bluuebunny/crossref_metadata_2025 huggingface dataset:
Paleoenvironment and Organic Matter Accumulation of the Upper Ordovician-Lower Silurian, in Upper Yangtze Region, South China: Constraints from Multiple Geochemical Proxies
Authors: Huang Zisang , Wang Xingzhi , Yang Xiyan , Zhu Rukai , Cui Jingwei , Shi Wenrui , Zhu Yiqing
Published: February 2020

The origin of the organic-rich shale in the Upper Ordovician Wufeng Formation and Lower Silurian Longmaxi Formation is complex and controversial. This paper reports the geochemical data of Wufeng-Longmaxi Formations in the Upper Yangtze region to restore the paleoenvironment and explore the accumulation mechanism of organic matter. The total organic carbon (TOC) content of the Wufeng Formation was relatively high, with an average of 2.86%. The Lower Longmaxi Formation showed the highest TOC content, with an average of 3.99%, and the upper part was a continuously low value with an average of 1.22%. The paleoproductivity proxies (Babio, Cu/Al, Ni/Al, Siexcess) showed that in the Katian and Rhuddanian-Aeronian Stages, the Upper Yangtze Sea had high primary productivity, indicating that organic matter accumulation was more affected by terrigenous influx and redox conditions. Al, Zr, and Zr/Al indicated that terrigenous influx was relatively high in the Kaitian-Hirnantian Stages, it was at a constant low in the Rhuddanian Stage, and increased again in the Aeronian Stage. The correlations between redox-sensitive trace elements (Mo, U, V) and TOC indicate that the organic-rich shale of the Wufeng Formation was deposited in the anoxic–euxinic environment. In the Longmaxi Formation, organic-rich shales formed in a more hypoxic environment, and overlying organic-lean shales formed in a suboxic environment. Therefore, the anoxic–euxinic conditions of the Late Ordovician Yangtze Sea were the main reason for the organic matter accumulation, but the high terrigenous influx caused by regression and/or structural controls diluted the organic matter to some extent. For the Early Silurian, a complete transgression–regression cycle changed terrigenous influx and redox conditions, resulting in significant differences in organic matter accumulation.
Short-Term Impact of Traffic-Related Particulate Matter and Noise Exposure on Cardiac Function
Authors: Buregeya Jean Marie , Apparicio Philippe , Gelb Jérémy
Published: February 2020

Exposure to traffic-related air pollution and noise exposure contributes to detrimental effects on cardiac function, but the underlying short-term effects related to their simultaneous personal exposure remain uncertain. The aim is to assess the impact of total inhaled dose of particulate matter and total noise exposure on the variations of electrocardiogram (ECG) parameters between pre-cycling and post-cycling periods. Mid-June 2019, we collected four participants’ personal exposure data related to traffic-related noise and particulate matter (PM2.5 and PM10) as well as ECG parameters. Several Bayesian linear models were built to examine a potential association between air pollutants and noise exposure and ECG parameters: heart rate (HR), standard deviation of the normal-to-normal intervals (SDNN), percentage of successive RR intervals that differ by more than 50 ms (pNN50), root mean square of successive RR interval differences (rMSSD), low-frequency power (LF), high-frequency power (HF), and ratio of low- to high-frequency power (LF/HF). We analyzed in total 255 5-min segments of RR intervals. We observed that per 1 µg increase in cumulative inhaled dose of PM2.5 was associated with 0.48 (95% CI: 0.22; 15.61) increase in variation of the heart rate, while one percent of total noise dose was associated with 0.49 (95% CI: 0.17; 0.83) increase in variation of heart rate between corresponding periods. Personal noise exposure was no longer significant once the PM2.5 was introduced in the whole model, whilst coefficients of the latter that were significant previously remained unchanged. Short-term exposure to traffic-related air and noise pollution did not, however, have an impact on heart rate variability.
Who Could Not Avoid Exposure to High Levels of Residence-Based Pollution by Daily Mobility? Evidence of Air Pollution Exposure from the Perspective of the Neighborhood Effect Averaging Problem (NEAP)
Authors: Ma Xinlin , Li Xijing , Kwan Mei-Po , Chai Yanwei
Published: February 2020

It has been widely acknowledged that air pollution has a considerable adverse impact on people’s health. Disadvantaged groups such as low-income people are often found to experience greater negative effects of environmental pollution. Thus, improving the accuracy of air pollution exposure assessment might be essential to policy-making. Recently, the neighborhood effect averaging problem (NEAP) has been identified as a specific form of possible bias when assessing individual exposure to air pollution and its health impacts. In this paper, we assessed the real-time air pollution exposure and residential-based exposure of 106 participants in a high-pollution community in Beijing, China. The study found that: (1) there are significant differences between the two assessments; (2) most participants experienced the NEAP and could lower their exposure by their daily mobility; (3) three vulnerable groups with low daily mobility and could not avoid the high pollution in their residential neighborhoods were identified as exceptions to this: low-income people who have low levels of daily mobility and limited travel outside their residential neighborhoods, blue-collar workers who spend long hours at low-end workplaces, and elderly people who face many household constraints. Public policies thus need to focus on the hidden environmental injustice revealed by the NEAP in order to improve the well-being of these environmentally vulnerable groups.
Experiences of the Built Environment, Falls and Fear of Falling Outdoors among Older Adults: An Exploratory Study and Future Directions
Authors: Curl Angela , Fitt Helen , Tomintz Melanie
Published: February 2020

Falls can have serious impacts on the health, wellbeing and daily mobilities of older adults. Falls are a leading cause of injury and death amongst older adults and outdoor falls comprise a substantial proportion of pedestrian injuries. As well as physical injuries, the psychological impacts of experiencing a fall can result in older adults getting out of the house less often, resulting in lower levels of physical activity and social connection. Despite the known consequences of falls, relatively little research considers the impact of the urban built environment on falls among older adults. This research aimed to explore the experiences of older adults in the urban environment, falling and the fear of falling outdoors. We conducted an online survey with adults aged 50+ using a participatory mapping survey tool and a convenience sample. The study area was Greater Christchurch, New Zealand. Results suggest that both perceived accessibility and neighbourhood conditions are independently associated with fear of falling, after controlling for frequency of falling, gender and activities of daily living. Our findings demonstrate the need for much better understandings of the relationships between the urban environment, outdoor mobility, fear of falling and falling among older adults and we propose suggestions for future research.
Latent Class Analysis Offers Insight into the Complex Food Environments of Native American Communities: Findings from the Randomly Selected OPREVENT2 Trial Baseline Sample
Authors: Jock Brittany Wenniserí:iostha , Bandeen Roche Karen , Caldas Stephanie V. , Redmond Leslie , Fleischhacker Sheila , Gittelsohn Joel
Published: February 2020

Native Americans (NAs) experience a high burden of obesity and diabetes, yet previous research has not holistically described the unique food environments of NA communities. The objective of this paper is to describe the subgroups and demographic characteristics related to NA household food environments. Surveys collected food getting, food assistance, and sociodemographic variables from randomly selected adults from three NA communities (n = 300) in the Midwest and Southwest. Exploratory latent class analysis (LCA) identified the appropriate number of subgroups based on indicator responses. After assigning participants to classes, demographic differences were examined using bivariate analyses. NA household food environments could be described using two subgroups (“lower” and “higher access household food environments”). The “lower access” group had significantly higher age, smaller household size, and fewer children per household than the “higher access” group, while body mass index (BMI) did not significantly vary. This is the first LCA of NA household food environments and highlights the need for approaches that characterize the complexity of these environments. Findings demonstrate that NA household food environments can be described by developing subgroups based on patterns of market and traditional food getting, and food assistance utilization. Understanding NA household food environments could identify tailored individual and community-level approaches to promoting healthy eating for NA Nations.
Regional Variation of Hospitalization Rates for Asthma in Korea: Association with Ambient Carbon Monoxide and Health Care Supply
Authors: Kim Agnus M. , Kang Sungchan , Park Jong Heon , Kim Yoon
Published: February 2020

This study was performed to investigate the relationship between the hospitalization rate for asthma and the ambient carbon monoxide (CO) by examining regional variation of the hospitalization rates for asthma in Korea and its factors. The hospital inpatient claims for asthma were acquired from the National Health Insurance database in 2015. A multivariate linear regression was performed with the hospitalization rate for asthma as a dependent variable. The annual ambient concentration of CO showed a negative association with the hospitalization rates for asthma while that of sulfur dioxide showed a positive association. The number of primary care physicians showed a negative association with the hospitalization rates for asthma while the number of beds in hospitals with less than 300 beds showed a positive association. The negative association of the ambient concentration of CO with the hospitalization rates for asthma showed results upon further investigation.
Garden-Based Integrated Intervention for Improving Children’s Eating Behavior for Vegetables
Authors: Kim Seon-Ok , Park Sin-Ae
Published: February 2020

This study was conducted to develop and verify the effects of a garden-based integrated intervention for improving children’s eating behavior for vegetables. A pre-post-test experimental design was employed. The participants were 202 elementary school students (average age: 11.6 ± 1.5 years). The garden-based integrated intervention program was conducted during regular school hours for a total of 12 weeks. The program, based on a mediator model for improving children’s eating behavior, included gardening, nutritional education, and cooking activities utilizing harvests. In order to examine effects of the program, the mediating factors related to children’s eating behavior were evaluated using pre-post questionnaires. As a result of the program, dietary self-efficacy, outcome expectancies, gardening knowledge, nutrition knowledge, vegetable preference, and vegetable consumption were significantly increased, and food neophobia was significantly decreased. In addition, there were positive correlations between most mediating factors. Thus, the garden-based integrated intervention developed in this study was effective in improving children’s eating behavior for vegetables.
Does Environmental Walkability Matter? The Role of Walkable Environment in Active Commuting
Authors: Kim Eun Jung , Kim Jiyeong , Kim Hyunjung
Published: February 2020

Since walkability plays an important role in active commuting, several cities are actively promoting its integration into urban and environmental planning policies. This study examined the association between walkability and active commuting in Seoul, Korea. A multilevel logistic regression model was used to examine the correlation between Walkability Score and the probability of active commuting after controlling for individual variables. The analysis used 129,044 individual samples nested within 424 administrative districts (dongs). In this study, three models were tested: Model 1 contained only individual variables, Model 2 contained individual variables and Walkability Score, and Model 3 included neighborhood-level variables in addition to the variables of Model 2. The results showed that the Walkability Score was significantly correlated with the odds of active commuting. Specifically, every additional one-point increase in Walkability Score was associated with 0.3% higher odds of active commuting (Model 2: odds ratio (OR) = 1.003, 95% confidence interval (CI) = 1.001–1.005; Model 3: OR = 1.003, 95% CI = 1.001–1.006). Additionally, public transportation density was also positively correlated with the odds of active commuting. The odds of active commuting were positively correlated with younger age, female, lower-income, and having no car. Based on the findings, policy recommendations in urban planning and design, transport engineering, and environmental planning are provided.
Knowledge Visualizations to Inform Decision Making for Improving Food Accessibility and Reducing Obesity Rates in the United States
Authors: Isokpehi Raphael D. , Johnson Matilda O. , Campos Bryanna , Sanders Arianna , Cozart Thometta , Harvey Idethia S.
Published: February 2020

The aim of this article is to promote the use of knowledge visualization frameworks in the creation and transfer of complex public health knowledge. The accessibility to healthy food items is an example of complex public health knowledge. The United States Department of Agriculture Food Access Research Atlas (FARA) dataset contains 147 variables for 72,864 census tracts and includes 16 food accessibility variables with binary values (0 or 1). Using four-digit and 16-digit binary patterns, we have developed data analytical procedures to group the 72,684 U.S. census tracts into eight and forty groups respectively. This value-added FARA dataset facilitated the design and production of interactive knowledge visualizations that have a collective purpose of knowledge transfer and specific functions including new insights on food accessibility and obesity rates in the United States. The knowledge visualizations of the binary patterns could serve as an integrated explanation and prediction system to help answer why and what-if questions on food accessibility, nutritional inequality and nutrition therapy for diabetic care at varying geographic units. In conclusion, the approach of knowledge visualizations could inform coordinated multi-level decision making for improving food accessibility and reducing chronic diseases in locations defined by patterns of food access measures.
Relationship between Cortisol Changes during the Night and Subjective and Objective Sleep Quality in Healthy Older People
Authors: Pulopulos Matias M. , Hidalgo Vanesa , Puig-Perez Sara , Montoliu Teresa , Salvador Alicia
Published: February 2020

The aim of this study was to investigate whether the nighttime cortisol release was associated with subjective and objective sleep quality and the discrepancy between them. Forty-five healthy older adults (age range from 56 to 75 years) collected salivary samples immediately before sleep and immediately after awakening on two consecutive nights. Actigraphy was used to assess objective sleep quality and quantity. A sleep diary was used to assess subjective sleep quality. Linear mixed models were performed using subjective and objective sleep quality data from 76 nights to investigate between-subject associations. We observed that larger changes in cortisol levels between sleep onset and awakening, reflecting a healthier circadian rhythm of the Hypothalamic-Pituitary-Adrenal (HPA) axis, were associated with better subjective sleep quality, but not with objective sleep quality. Moreover, smaller changes in nighttime cortisol were associated with lower subjective sleep quality relative to objective sleep quality. All these results were observed even after controlling for important confounders such as sleep quantity, age, sex, subjective socioeconomic status, stress perception, depression, physical activity, and adherence to the salivary sampling protocol. This study demonstrates that subjective sleep quality in older people may be explained, to some extent, by the activity of the HPA axis.
The Associations of Income, Education and Income Inequality and Subjective Well-Being among Elderly in Hong Kong—A Multilevel Analysis
Authors: Lai Eric TC , Yu Ruby , Woo Jean
Published: February 2020

Background: Higher income and education and lower income inequality in a neighbourhood have been shown to be related to better mental health outcome in developed countries. However, it is not clear whether these factors would affect the subjective well-being of the elderly, especially in a setting with recent rapid economic development. Methods: This study was conducted in 80 community centres with a total of 7552 community-dwelling elderly (mean age 75.9 years (SD = 7.79), 79% female) in Hong Kong. Income at individual level was measured as perceived disposable income. Education level was also collected. At district level, income was measured by district median household income and education was measured as the proportion of the population with no formal schooling. Income inequality was quantified using Gini coefficients. Low subjective well-being was defined as any one or a combination of the following: not satisfied with life, no meaning of life and being unhappy (Likert scale ≤ 2). Multilevel logistic regression was used to assess the association of income, education and income inequality and low subjective well-being. Results: We found that 15.3% (95% confidence interval (CI): 14.5 to 16.1) of the elderly have low subjective well-being. Compared with elderly who reported a very adequate disposable income, those who reported a very inadequate disposable income are at increased risk of low subjective well-being (OR=5.08, 95%CI: 2.44 to 10.59). Compared with elderly with tertiary education, those with no formal schooling were at higher risk (OR=1.60, 95%CI 1.22 to 2.09). Income inequality was not related to subjective well-being. Conclusions: Elderly with inadequate disposable income and lower education level are more likely to suffer from low subjective well-being. At the neighbourhood level, income inequality was not related to subjective well-being. However, the relationships between neighbourhood income and education level and individuals’ subjective well-being are not clear.
Relationships between Foot Morphology and Foot Muscle Strength in Healthy Adults
Authors: Xiao Songlin , Zhang Xini , Deng Liqin , Zhang Shen , Cui Kedong , Fu Weijie
Published: February 2020

The purpose of this study was to investigate if measurements of foot morphology in sitting and standing positions can predict foot muscle strength. Twenty-six healthy male adults were recruited, and their foot morphology and foot muscle strength were measured. Foot morphological variables, toe flexor strength, and metatarsophalangeal joint flexor strength were measured by using a digital caliper, Ailitech-AFG500 dynameter and metatarsophalangeal joint flexor strength tester, respectively. Partial correlation and multivariate stepwise regression were used to explore the relationships between foot morphology and toe/metatarsophalangeal joint strength. Results adjusted by age and body mass index were as follows: (1) truncated foot length in sitting and standing positions and foot width in standing position were positively correlated with the flexor strength of the first toe; (2) foot length, foot width, and truncated foot length in both positions were positively related to the flexor strength of the other toes; (3) arch height index in sitting position and differences in navicular height were negatively associated with the flexor strength of the other toes; (4) differences in foot width were negatively associated with metatarsophalangeal joint flexor strength; and (5) the multivariate stepwise regression model showed that truncated foot length in sitting position, navicular height in standing position, differences in navicular height, foot width in sitting position, and differences in foot width were significantly correlated with toe/metatarsophalangeal joint flexor strength. Simple measurements of foot morphological characteristics can effectively predict foot muscle strength. Preliminary findings provided practical implications for the improvement of the foot ability by making specific foot muscle training sessions in professional sports and by compensating the predicted muscle strength defects to prevent foot injury.
Can Age-Friendly Planning Promote Equity in Community Health Across the Rural-Urban Divide in the US?
Authors: Zhang Xue , Warner Mildred E. , Wethington Elaine
Published: February 2020

In the US, rural communities face challenges to meet the community health needs of older adults and children. Meanwhile, rural areas lag in age-friendly built environment and services. AARP, a US based organization promoting livability for all ages, has developed a Livability Index based on the World Health Organization’s (WHO) domains of age-friendly communities: health, housing, neighborhood, transportation, environment, engagement, and opportunity. This study links the 2018 AARP Livability Index categories with demographic structure and socio-economic factors from the American Community Survey at the county level in the US to examine if the physical, built and social environment differentiate communities with better community health across the rural–urban divide. Results show that the neighborhood built environment has the largest impact on community health for all county types. Although rural areas lag in community health, those which give more attention to engagement and opportunity rank higher. Rural communities with more African Americans, children, and poor Whites, rank lower on community health. While neighborhood characteristics have the strongest link to community health, a broader approach with attention to age, race, poverty and engagement and opportunity is needed for rural areas.
Levels and Determinants of Fine Particulate Matter and Carbon Monoxide in Kitchens Using Biomass and Non-Biomass Fuel for Cooking
Authors: Fatmi Zafar , Ntani Georgia , Coggon David
Published: February 2020

To assist interpretation of a study in rural Pakistan on the use of biomass for cooking and the risk of coronary heart disease, we continuously monitored airborne concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO) for up to 48 h in the kitchens of households randomly selected from the parent study. Satisfactory data on PM2.5 and CO respectively were obtained for 16 and 17 households using biomass, and 19 and 17 using natural gas. Linear regression analysis indicated that in comparison with kitchens using natural gas, daily average PM2.5 concentrations were substantially higher in kitchens that used biomass in either a chimney stove (mean difference 611, 95% CI: 359, 863 µg/m3) or traditional three-stone stove (mean difference 389, 95% CI: 231, 548 µg/m3). Daily average concentrations of CO were significantly increased when biomass was used in a traditional stove (mean difference from natural gas 3.7, 95% CI: 0.8, 6.7 ppm), but not when it was used in a chimney stove (mean difference −0.8, 95% CI: −4.8, 3.2 ppm). Any impact of smoking by household members was smaller than that of using biomass, and not clearly discernible. In the population studied, cooking with biomass as compared with natural gas should serve as a good proxy for higher personal exposure to PM2.5.
Water Exercise and Quality of Life in Pregnancy: A Randomised Clinical Trial
Authors: Rodríguez-Blanque Raquel , Aguilar-Cordero María José , Marín-Jiménez Ana Eugenia , Menor-Rodríguez María José , Montiel-Troya Maria , Sánchez-García Juan Carlos
Published: February 2020

Background: Physical exercise helps to maintain a healthy lifestyle and its practice is recommended for women during pregnancy as a means of limiting the negative effects on the body that may take place and to optimise well-being, mood and sleep patterns, as well as encouraging daily physical activity, enhancing the ability to work and preventing pregnancy-related complications. Aim: To analyse the quality of life in pregnancy for women who complete a programme of moderate physical activity in water, following a designed method that the woman can perform physical exercise safely during pregnancy called the SWEP (study of water exercise during pregnancy) method. Materials and methods: A randomised clinical trial was performed. One hundred and twenty-nine pregnant women were randomly assigned either to an exercise class following the SWEP method (EG, n = 65) or to a control group (CG, n = 64). The trial began in week 20 of pregnancy (May 2016) and ended in week 37 (October 2016). Heath-related quality of life (HRQoL) was evaluated with the SF36v2 health questionnaire at weeks 12 and 35 of pregnancy. Results: The HRQoL score decreased significantly between weeks 12 and 35 of gestation, except for the mental health component, which in the CG fell by −3.28 points and in the EG increased slightly (p > 0.05). Among the CG, the score for the mental health component at week 35 was ≤42, indicating a positive screening risk of depression (39.20 ± 4.16). Conclusions: Physical activity programmes in water, such as SWEP, enhance the HRQoL of pregnant women.
Energy Drink Consumption, Depression, and Salutogenic Sense of Coherence Among Adolescents and Young Adults
Authors: Tóth Ákos , Soós Rita , Szovák Etelka , M. Najbauer Noemi , Tényi Dalma , Csábí Györgyi , Wilhelm Márta
Published: February 2020

The prevalence of energy drink consumption has increased in Hungary over the past 10–15 years. This study assesses the frequency, motivations, and adverse effects of energy drink consumption, and examines how the process of becoming a regular consumer is connected with sense of coherence and depression symptoms. A total of 631 high school and college students were assessed using the Depression Scale (BDS-13) and Sense of Coherence Scale (SOC-13). Logistic regression models were fit to test the effect of and links between factors influencing addiction to energy drink use. A total of 31.1% (95% CI: 27.4–34.7) of those surveyed consumed energy drinks, 24.0% of those affected consumed the energy drink with alcohol, 71.4% (95% CI: 64.7–77.3) experienced adverse effects following energy drink consumption, and 10.2% (95% CI: 6.7–15.2) experienced at least four symptoms simultaneously. The most common motivations of consumption were fatigue, taste, and fun. Obtained by multivariate logistic regression models, after adjustment for sex and age, SOC and tendency to depression had a significant influence on the respondents’ odds of addiction. The tendency to depression increases the chances of addiction, while a strong sense of coherence diminishes the effects of depression. Young people in Hungary have been shown to consume energy drinks in quantities that are detrimental to their health. Complex preventive measures and programs are needed to address the problem. Families and educators should strive to instill a strong sense of coherence in children from an early age.
Evaluation of Mother’s Stress during Hospitalization Can Influence the Breastfeeding Rate. Experience in Intensive and Non Intensive Departments
Authors: Foligno S. , Finocchi A. , Brindisi G. , Pace A. , Amadio P. , Dall’Oglio I. , Portanova A. , Rossi P. , Dotta A. , Salvatori G.
Published: February 2020

A mother’s milk offers several benefits to infant’s health, but, some factors may lead to a reduction in the duration of breastfeeding, such as maternal stress. The objective of our study is to determine if the rate of breastfeeding can be influenced by stress induced by infants’ hospitalization. A preliminary observational non-randomized study was carried out in Bambino Gesù Children’s Hospital between October 2016 and January 2017, in order to elucidate a possible relationship between breastfeeding and maternal stress, linked to hospitalization. We modeled the modified version of the PSS NICU (Parental Stressor Scale—neonatal intensive care unit) questionnaire, which investigated parental stress during hospitalization. This included 33 items with a score from 0 to 5. The overall score, high stress, was established at 85 points or higher. The principal statistically significant correlation was between ‘high PSS score’ and reduced breastfeeding during hospitalization (p-value: 0.048; OR: 2.865, 95%; CI: 1.008–8.146). This relation was not influenced by other descriptive characteristics of the mother. The PSS questionnaire can be an instrument to evaluate the influence of stress in breastfeeding and to monitor the rate and success of lactation. Our study highlights that the stress from hospitalization could influence the success of breastfeeding, mostly in intensive settings and during long hospitalizations.
Satisfaction with Life, Subjective Well-Being and Functional Skills in Active Older Adults Based on Their Level of Physical Activity Practice
Authors: Parra-Rizo María Antonia , Sanchis-Soler Gema
Published: February 2020

Studies about the influence of physical activity on life satisfaction, functional ability and subjective well-being in physically active older adults without cognitive impairment are very few for the moment. Therefore, the aim of this research was to evaluate the life satisfaction, functional skills and subjective well-being of physically active older adults based on the level of activity practiced. The IPAQ (International Physical Activity), CUBRECAVI and LSIA (Life Satisfaction Index) scales were tested for a sample of 397 Spanish older adults between 61 and 93 years of age (M = 69.65; SD = 4.71). The results showed that those who performed high physical activity obtained higher scores in functional skills (p < 0.01) and in the activities of daily living (p < 0.01). In addition, subjective well-being (p < 0.01) and the functional autonomy of older adults (p < 0.01) were related to the level of physical activity that they practiced. In conclusion, it could be said that the older adults with a high level of physical activity have more functional skills and less difficulties performing the activities of daily living, and that they value their autonomy and health better.
A Horticultural Therapy Program Focused on Succulent Cultivation for the Vocational Rehabilitation Training of Individuals with Intellectual Disabilities
Authors: Joy Yang Suk , Lee A-Young , Park Sin-Ae
Published: February 2020

We aimed to develop a horticultural therapy program for the vocational rehabilitation of individuals with intellectual disabilities and examine its effects. Individuals with intellectual disabilities (n = 28, average age: 33.23 ± 4.9 years) were recruited from a welfare center in Jecheon, South Korea. They participated in eight weekly sessions of a horticultural therapy program consisting of common succulent cultivation techniques at a specialized succulent cultivation farm located in Jecheon, South Korea. Before and after the program, we assessed hand function (grip strength, pinch force, and hand dexterity, evaluated using a hand dynamometer, Jamar hydraulic pinch gauge, and grooved pegboard, respectively), emotional behavioral strategies (evaluated using the emotional behavioral checklist), and social skills (evaluated using the social skill rating system-teacher form). After participation in the horticultural therapy program, individuals with intellectual disabilities displayed significantly improved hand function, emotional behavior, and social skills (all p < 0.05). This study demonstrates the potential of horticultural therapy focused on succulent cultivation for the vocational training of individuals with intellectual disabilities. Future studies should investigate the effects of the program in a larger cohort.
Treatment with Gold Nanoparticles Using Cudrania tricuspidata Root Extract Induced Downregulation of MMP-2/-9 and PLD1 and Inhibited the Invasiveness of Human U87 Glioblastoma Cells
Authors: Park Sun Young , Cui Zhengwei , Kim Beomjin , Park Geuntae , Choi Young-Whan
Published: February 2020

In this study, we aimed to elucidate the anti-invasive effects of Cudrania tricuspidata root-gold nanoparticles (CTR-GNPs) using glioblastoma cells. We demonstrated the rapid synthesis of CTR-GNPs using UV-vis spectra. The surface morphology, crystallinity, reduction, capsulation, and stabilization of CTR-GNPs were analyzed using high resolution transmission electron microscopy (HR-TEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FT-IR). Furthermore, CTR-GNPs displayed excellent photocatalytic activity as shown by the photo-degradation of methylene blue and rhodamine B. Cell migration and invasion assays with human glioblastoma cells were performed to investigate the anti-invasive effect of CTR-GNPs on U87 cells that were treated with phorbol 12-myristate 13-acetate. The results show that CTR-GNPs can significantly inhibit both basal and phorbol 12-myristate 13-acetate (PMA)-induced migration and invasion ability. Importantly, treatment with CTR-GNPs significantly decreased the levels of metalloproteinase (MMP)-2/-9 and phospholipase D1 (PLD1) and protein but not PLD2, which is involved in the modulation of migration and the invasion of glioblastoma cells. These results present a novel mechanism showing that CTR-GNPs can attenuate the migration and invasion of glioblastoma cells induced by PMA through transcriptional and translational regulation of MMP-2/-9 and PLD1. Taken together, our results suggest that CTR-GNPs might be an excellent therapeutic alternative for wide range of glioblastomas.
Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphocytes
Authors: Lambert Jean-Marie , Ashi Mohamad Omar , Srour Nivine , Delpy Laurent , Saulière Jérôme
Published: February 2020

The presence of premature termination codons (PTCs) in transcripts is dangerous for the cell as they encode potentially deleterious truncated proteins that can act with dominant-negative or gain-of-function effects. To avoid the synthesis of these shortened polypeptides, several RNA surveillance systems can be activated to decrease the level of PTC-containing mRNAs. Nonsense-mediated mRNA decay (NMD) ensures an accelerated degradation of mRNAs harboring PTCs by using several key NMD factors such as up-frameshift (UPF) proteins. Another pathway called nonsense-associated altered splicing (NAS) upregulates transcripts that have skipped disturbing PTCs by alternative splicing. Thus, these RNA quality control processes eliminate abnormal PTC-containing mRNAs from the cells by using positive and negative responses. In this review, we describe the general mechanisms of NMD and NAS and their respective involvement in the decay of aberrant immunoglobulin and TCR transcripts in lymphocytes.
Ethyl Acetate Fraction of Aqueous Extract of Lentinula edodes Inhibits Osteoclastogenesis by Suppressing NFATc1 Expression
Authors: Lee Hyerim , Lee Kyubin , Lee Sheunghun , Lee Jisu , Jeong Won Tae , Lim Heung Bin , Hyun Tae Kyung , Yi Sun-Ju , Kim Kyunghwan
Published: February 2020

Bone tissue is continuously remodeled by the coordinated action of osteoclasts and osteoblasts. Nuclear factor-activated T cells c1 (NFATc1) is a well-known transcription factor for osteoclastogenesis and transcriptionally activated by the c-Fos and nuclear factor-kappa B (NF-κB) signaling pathways in response to receptor activation of NF-κB ligand (RANKL). Since excessive RANKL signaling causes an increase of osteoclast formation and bone resorption, inhibition of RANKL or its signaling pathway is an attractive therapeutic approach to the treatment of pathologic bone loss. In this study, we show that an ethyl acetate fraction (LEA) from the shiitake mushroom, Lentinula edodes, inhibited RANKL-induced osteoclast differentiation by blocking the NFATc1 signaling pathway. We found that the water extract and its subsequent ethyl acetate fraction of L. edodes significantly suppressed osteoclast formation. Comparative transcriptome analysis revealed that LEA specifically downregulated a set of RANKL target genes, including Nfatc1. Next, we found that LEA suppresses Nfatc1 expression mainly through the inhibition of the transactivity of p65 and NFATc1. Moreover, treatment of LEA rescued an osteoporotic phenotype in a zebrafish model of glucocorticoid-induced osteoporosis. Collectively, our findings define an undocumented role of the shiitake mushroom extract in regulating bone development.
Group 2 Innate Lymphoid Cells: Central Players in a Recurring Theme of Repair and Regeneration
Authors: Messing Melina , Jan-Abu Sia Cecilia , McNagny Kelly
Published: February 2020

Innate lymphoid cells (ILCs) are recently discovered innate counterparts to the well-established T helper cell subsets and are most abundant at barrier surfaces, where they participate in tissue homeostasis and inflammatory responses against invading pathogens. Group 2 innate lymphoid cells (ILC2s) share cytokine and transcription factor expression profiles with type-2 helper T cells and are primarily associated with immune responses against allergens and helminth infections. Emerging data, however, suggests that ILC2s are also key regulators in other inflammatory settings; both in a beneficial context, such as the establishment of neonatal immunity, tissue repair, and homeostasis, and in the context of pathological tissue damage and disease, such as fibrosis development. This review focuses on the interactions of ILC2s with stromal cells, eosinophils, macrophages, and T regulatory cells that are common to the different settings in which type-2 immunity has been explored. We further discuss how an understanding of these interactions can reveal new avenues of therapeutic tissue regeneration, where the role of ILC2s is yet to be fully established.
Repeated Usage of an L3 Motorway Chauffeur: Change of Evaluation and Usage
Authors: Metz Barbara , Wörle Johanna , Hanig Michael , Schmitt Marcus , Lutz Aaron
Published: February 2020

Most studies on users’ perception of highly automated driving functions are focused on first contact/single usage. Nevertheless, it is expected that with repeated usage, acceptance and usage of automated driving functions might change this perception (behavioural adaptation). Changes can occur in drivers’ evaluation, in function usage and in drivers’ reactions to take-over situations. In a driving simulator study, N = 30 drivers used a level 3 (L3) automated driving function for motorways during six experimental sessions. They were free to activate/deactivate that system as they liked and to spend driving time on self-chosen side tasks. Results already show an increase of experienced trust and safety, together with an increase of time spent on side tasks between the first and fourth sessions. Furthermore, attention directed to the road decreases with growing experience with the system. The results are discussed with regard to the theory of behavioural adaptation. Results indicate that the adaptation of acceptance and usage of the highly automated driving function occurs rather quickly. At the same time, no behavioural adaptation for the reaction to take-over situations could be found.
Facial Emotion Recognition Using Hybrid Features
Authors: Alreshidi Abdulrahman , Ullah Mohib
Published: February 2020

Facial emotion recognition is a crucial task for human-computer interaction, autonomous vehicles, and a multitude of multimedia applications. In this paper, we propose a modular framework for human facial emotions’ recognition. The framework consists of two machine learning algorithms (for detection and classification) that could be trained offline for real-time applications. Initially, we detect faces in the images by exploring the AdaBoost cascade classifiers. We then extract neighborhood difference features (NDF), which represent the features of a face based on localized appearance information. The NDF models different patterns based on the relationships between neighboring regions themselves instead of considering only intensity information. The study is focused on the seven most important facial expressions that are extensively used in day-to-day life. However, due to the modular design of the framework, it can be extended to classify N number of facial expressions. For facial expression classification, we train a random forest classifier with a latent emotional state that takes care of the mis-/false detection. Additionally, the proposed method is independent of gender and facial skin color for emotion recognition. Moreover, due to the intrinsic design of NDF, the proposed method is illumination and orientation invariant. We evaluate our method on different benchmark datasets and compare it with five reference methods. In terms of accuracy, the proposed method gives 13% and 24% better results than the reference methods on the static facial expressions in the wild (SFEW) and real-world affective faces (RAF) datasets, respectively.
Ultimate Limit State Function and Its Fitting Method of Damaged Ship under Combined Loads
Authors: Zhu Zhiyao , Ren Huilong , Li Chenfeng , Zhou Xueqian
Published: February 2020

The ultimate limit state function is one of the premises for the assessment of structure strength and the safety of ships under severe conditions. In order to study the residual strength of damaged ships under the combined load of vertical and horizontal bending moments acting on the hull girder, the ultimate limit state function of a damaged ship under combined load, and its fitting methods are investigated in this paper. An improved Smith Method is adopted to calculate the residual load carrying capacity of damage ships, where the rotation and translation of the neutral axis of the damaged cross-section are obtained using a particle swarm optimisation method. Because the distribution curve of the residual load carrying capacity of a damaged ship under combined load is asymmetric, the application of traditional explicit polynomial fitting methods results in poor accuracy. In this study, a piecewise weighted least square fitting method is adopted so as to guarantee the continuity in the transitions, and a method is proposed for fitting the ultimate limit state function of a damaged ship under combined load. Calculations of the residual strength show that the improved Smith Method is more accurate than the original Smith Method for the accurate position of the neutral axis. The error analysis of the fitting methods shows that the ultimate limit state function that is fitted using a piecewise weight least square method is more accurate.
Mitigation Effect of Perforation Drilling on the Sliding Risk during Spudcan Installation Close to Footprints
Authors: Gao Pan , Liu Zhihui , Shi Danda , Fu Xuehua , Yan Keliang
Published: February 2020

Perforation drilling is a promising technique to mitigate the sliding risk of jack-up units installed around footprints. Based on the coupled Eulerian–Lagrangian (CEL) method, a 1/2 finite element model, including a rigid Lagrangian spudcan and a Eulerian soil part, was established, and the contact interface was modelled with the Coulomb friction model. Validated against an indoor perforation test, the model was adopted to investigate the mitigation mechanism and effects of the borehole diameter, number, depth, and the drilling range. The simulations reveal that the mitigation efficiency increases with the borehole diameter, number, and depth. However, it shows little improvement if the borehole depth increases beyond double footprint depth. The semi-drilling at the outer side of the footprint is a little more effective than the full-drilling at both the inner and outer sides of the footprint. The present work emphasizes the effects of perforation drilling parameters on the mitigation efficiency, which are of great significance to guide the engineering practice and guarantee the safe operation of the jack-up reinstallation close to existing footprints.
Offshore Wind Farms
Authors: Esteban María Dolores , López-Gutiérrez José-Santos , Negro Vicente
Published: February 2020

In 2018, we were approached by the editorial team of the Journal of Marine Science and Engineering (MDPI editorial) to act as guest editors of a Special Issue related to offshore wind energy [...]
The Impact of the Underwater Hull Anti-Fouling Silicone Coating on a Ferry’s Fuel Consumption
Authors: Kowalski Adam
Published: February 2020

There are well-known specifics of ro-pax ferry shipping, such as the time factor as a consequence of keeping a regular timetable and the priority given to minimizing heeling, pitching, and rolling caused by maximum focus on passenger comfort and ro-ro cargo safety. It is also extremely important to control the ferry’s fuel consumption, being one of the most important cost components. The aim of the article is to draw the attention of shipping company managers to the great potential that lies in the use of routine operational data, collected exclusively on board the ferries. It is worth noting that the research in this paper is based on standard office software packages rather than advanced statistical methods of data analysis, which are usually not accessible for shipping managers. Contrary to typical ocean-going vessels, there are a number of factors that need to be taken into consideration when analyzing ro-pax ferry fuel consumption. Moreover, these factors occur, in many cases, accidentally and, thus, they are difficult to observe on board the ferry without utilizing expensive and time-consuming methods. The possibility of fuel control is important not only for economic reasons but also due to air pollution caused by engine exhausts. The article presents an estimation of increased fuel consumption caused by the degradation of the hull silicone anti-fouling coating. The presented estimations of fuel consumption may be treated as the base for calculations of the economic effectiveness of ferries. The attempt to resolve the above-mentioned problem was made on the basis of research on a real ferry, which took place on the Świnoujście-Trelleborg line between 2007 and 2019.
Experimental Study on 2D Motion Characteristics of Submerged Floating Tunnel in Waves
Authors: Yang Zhiwen , Li Jinzhao , Zhang Huaqing , Yuan Chunguang , Yang Hua
Published: February 2020

Submerged floating tunnel (SFT) is a new type of transportation infrastructure for crossing sea straits in relatively deeper water. Compared with the fixed tunnel, the main challenge in designing a SFT is the stability maintaining in a complex hydrodynamic environment, especially for the wave-induced dynamic load. In this study, a series of systematic experiments were conducted to investigate the 2D motion characteristics (i.e., heave, sway and roll) of the SFT exposed to regular waves. The movement of the SFT model is measured by the image processing method which is a noncontact measurement. The experimental observation of SFT motion during the process of wave and SFT interaction is described in detail, and the influence of several governing parameters is thoroughly analyzed, including the wave height and period, submergence depth, buoyancy to weight ratio (BWR), and the mooring line angle. The results show that the motion amplitudes of SFT increase with the wave height increasing. The effect of wave period is related to the natural period of the structure. The sway, heave and roll of the SFT submerged beneath the water surface are much smaller than that of the SFT on the water surface. With the increase of BWR, the motion of SFT decreases. The motion amplitude increases with mooring line angle increasing. Finally, empirical equations are proposed to estimate the motion characteristics of the SFT.