bluuebunny/crossref_metadata_2025 huggingface dataset:
Bariatric Surgery Outcomes in Patients with Inflammatory Bowel Disease in the United States: An Analysis of the Nationwide Readmissions Database
Authors: Wilson Noah C. , Dilsaver Danielle B. , Walters Ryan W. , Nandipati Kalyana C.
Published: February 2024

Purpose

Bariatric surgery has been reported to produce durable weight loss in the management of obesity; sleeve gastrectomy (SG) is the most common bariatric procedure. Obesity is a common comorbidity of inflammatory bowel disease (IBD), and the impact of IBD on short-term SG outcomes has not been widely reported. This study assessed whether IBD was associated with adverse post-SG outcomes.

Materials and Methods

Hospitalizations of patients undergoing SG in the United States were identified using the 2010–2020 Nationwide Readmissions Database (NRD) and stratified by IBD diagnosis. The SG cohort was propensity-matched based on age, biological sex, body mass index (BMI), comorbid diabetes, hypertension, depression, chronic obstructive pulmonary disease, and discharge in quarter four. Primary aims were to compare in-hospital mortality, post-operative complications, and all-cause 90-day readmission between patients with and without IBD. Secondary outcomes were length of stay (LOS) and total hospital cost.

Results

A total of 2030 hospitalizations were matched. The odds of complication were 48% higher for hospitalizations of patients with IBD (11.1% vs. 7.8%; aOR 1.48, aOR 95% CI 1.10–2.00, p = .009). The most common complication was nausea (4.9% vs. 3.7%, p = .187). No statistically significant difference was observed for all-cause 90-day readmissions, LOS, or hospital cost.

Conclusion

Hospitalizations of patients with IBD who underwent SG experienced significantly higher post-operative complication rates. However, the similar lengths of stay and readmission rates compared to propensity-matched SG hospitalizations without IBD suggest many complications were minor. SG remains a safe weight loss procedure for patients suffering from IBD and obesity.

Graphical Abstract
A Systematic Review and Meta-analysis of the Socioeconomic, Lifestyle, and Environmental Factors Associated with Healthy Ageing in Low and Lower-Middle-Income Countries
Authors: Belachew Amare , Cherbuin Nicolas , Bagheri Nasser , Burns Richard
Published: February 2024

Population ageing is a growing social and health issue in low and lower-middle-income countries (LLMIC). It will have an impact on rising healthcare costs, unaffordable pension liabilities, and changing healthcare demands. The health systems of many LLMICs are unprepared to meet these challenges and highlighting the modifiable factors that may help decrease these pressures is important. This review assessed the prevalence of healthy ageing and the modifiable factors that may promote/inhibit healthy ageing among older people in LLMIC. A systematic search of all articles published from 2000 to June 2022 was conducted in Scopus, PubMed (MEDLINE), and Web of Science. All observational studies reporting the prevalence of healthy ageing and its associations with socio-demographic, lifestyle, psychological, and social factors were examined. Random-effect models were used to estimate the pooled prevalence of healthy ageing, and meta-analyses were conducted to assess the risk/benefit of modifiable factors. From 3,376 records, 13 studies (n = 81,144; 53% of females; age ≥ 60 years) met the inclusion criteria. The pooled prevalence of healthy ageing ranged from 24.7% to 56.5% with lower prevalence for a multi-dimensional model and higher prevalence for single global self-rated measures. Factors positively associated with healthy ageing included education, income, and physical activity. Being underweight was negatively associated with healthy ageing. Almost half of older people in LLMIC were found to meet healthy ageing criteria, but this estimate varied substantially depending on the healthy ageing measures utilized (multi-dimensional = 24.7%; single indicator = 56.5%). The healthy ageing prevalences for both measures are lower compared to that in high-income countries. Developing health policies and educative interventions aimed at increasing physical exercise, social support, and improving socio-economic status and nutrition will be important to promote the healthy ageing of older people in LLMIC in sustainable ways.
Large-eddy simulation-based reconstruction of turbulence in a neutral boundary layer using spectral-tensor regularization
Authors: Alreweny Ahmed , Vandewalle Stefan , Meyers Johan
Published: February 2024

We propose an efficient method to reconstruct the turbulent flow field in a neutrally stratified atmospheric boundary layer using large-eddy simulation (LES) and a series of lidar measurements. The reconstruction is formulated as a strong four-dimensional variational data assimilation problem, which involves optimizing two competing terms that contribute in the objective functional. The first term is a likelihood term, while the second contains the initial background distribution of turbulent velocity fluctuations and works as a regularization term. However, computing and storing the full background covariance tensor in turbulent flows is time consuming and resource intensive. In the current work, we investigate the possibility of replacing the complex background tensor by simple analytical approximations based on spectral tensors such as the Hunt–Graham–Wilson (HGW) model (Boundary-Layer Meteorol., vol. 85, 1997, pp. 35–52) or the Mann model (J. Fluid Mech., vol. 273, 1994, pp. 141–168). Afterwards, the problem is solved using a quasi-Newton algorithm and preconditioned to enhance the convergence rate. We test the method using virtual lidar measurements collected on a fine reference LES. Results show a super-linear convergence rate of the optimization algorithm to a local minimum and very good agreement between virtual lidar measurements and reconstruction in the scanning region. Furthermore, we demonstrate that incorporating the Saffman energy spectrum (

$E(k) \sim k^2$

where E is the energy spectrum and k is the magnitude of the wavenumber vector) at low wavenumbers into the Mann spectral tensor yields a longer streamwise correlation length, resulting in reduced reconstruction error when compared with the Batchelor spectrum (

$E(k) \sim k^4$

). Finally, we observe that using the HGW model or Mann model with a Saffman spectrum yields similar results.
Dark Sage: Next-generation semi-analytic galaxy evolution with multidimensional structure and minimal free parameters
Authors: Stevens Adam R. H. , Sinha Manodeep , Rohl Alexander , Sammons Mawson W. , Hadzhiyska Boryana , Hernández-Aguayo César , Hernquist Lars
Published: February 2024

After more than five years of development, we present a new version of Dark Sage, a semi-analytic model (SAM) of galaxy formation that breaks the mould for models of its kind. Included among the major changes is an overhauled treatment of stellar feedback that is derived from energy conservation, operates on local scales, affects gas gradually over time rather than instantaneously, and predicts a mass loading factor for every galaxy. Building on the model’s resolved angular momentum structure of galaxies, we now consider the heating of stellar discs, delivering predictions for disc structure both radially and vertically. We add a further dimension to stellar discs by tracking the distribution of stellar ages in each annulus. Each annulus–age bin has its own velocity dispersion and metallicity evolved in the model. This allows Dark Sage to make structural predictions for galaxies that previously only hydrodynamic simulations could. We present the model as run on the merger trees of the highest-resolution gravity-only simulation of the MillenniumTNG suite. Despite its additional complexity relative to other SAMs, Dark Sage only has three free parameters, the least of any SAM, which we calibrate exclusively against the cosmic star formation history and the

$z = 0$

stellar and H i mass functions using a particle-swarm optimisation method. The Dark Sage codebase, written in C and python, is publicly available at https://github.com/arhstevens/DarkSage.
COMPARATIVE FEATURES OF BINP AMS AND MICADAS FACILITIES WORKING AT AMS GOLDEN VALLEY, RUSSIA
Authors: Petrozhitskiy A V , Parkhomchuk E V , Ignatov M M , Kuleshov D V , Kutnyakova L A , Konstantinov E S , Parkhomchuk V V
Published: February 2024

The AMS Golden Valley radiocarbon analysis laboratory is equipped with two accelerator mass spectrometers: AMS facility from Budker Institute of Nuclear Physics (BINP AMS) and MIni CArbon DAting System (MICADAS-28) from Ionplus AG and two graphitization systems: Automated Graphitization Equipment (AGE-3) from Ionplus AG and Absorption-catalytic setup developed in Boreskov Institute of Catalysis (ACS BIC). The laboratory provides routine 14C analyses of various samples: collagen, cellulose, humic acids, carbonates from sediments, etc. The main focus of the laboratory is to determine the age of archaeological artifacts by radiocarbon dating. This work presents a comprehensive description of the BINP AMS facility, with its operation compared with that of MICADAS in the same laboratory. In 2022, the AMS Golden Valley laboratory participated for the first time in the Glasgow International Radiocarbon Inter-comparison (GIRI). The samples were graphitized on the AGE-3 and subsequently measured in both AMS facilities. A comparison of the results of the two series of experiments, namely AGE-3 + MICADAS-28 and AGE-3 + BINP AMS, is given.
Feedbacks Between Estuarine Metabolism and Anthropogenic CO2 Accelerate Local Rates of Ocean Acidification and Hasten Threshold Exceedances
Authors: Pacella Stephen R. , Brown Cheryl A. , Labiosa Rochelle G. , Hales Burke , Mochon Collura T. Chris , Evans Wiley , Waldbusser George G.
Published: February 2024

Attribution of the ocean acidification (OA) signal in estuarine carbonate system observations is necessary for quantifying the impacts of global anthropogenic CO2 emissions on water quality, and informing managers of the efficacy of potential mitigation options. We present an analysis of observational data to characterize dynamics and drivers of seasonal carbonate system variability in two seagrass habitats of Puget Sound, WA, USA, and estimate how carbon accumulations due to anthropogenic CO2 emissions (Canth) interact with these drivers of carbonate chemistry to determine seasonally resolved rates of acidification in these habitats. Three independent simulations of Canth accumulation from 1765 to 2100 were run using two previously published methods and one novel method for Canth estimation. Our results revealed persistent seasonal differences in the magnitude of carbonate system responses to anthropogenic CO2 emissions caused by seasonal metabolic changes to the buffering capacity of estuarine waters. The seasonal variability of pHT and pCO2 is increased (while that of Ωaragonite is decreased) and acidification rates are accelerated when compared with open‐ocean estimates, highlighting how feedbacks between local metabolism and Canth can control the susceptibility of estuarine habitats to OA impacts. The changes in seasonal variability can shorten the timeline to exceedance of established physiological thresholds for endemic organisms and existing Washington State water quality criteria for pH. We highlight how Canth estimation uncertainties manifest in shallow coastal waters and limit our ability to predict impacts to coastal organisms and ecosystems from anthropogenic CO2 emissions.
Simulating the Unsteady Stable Boundary Layer With a Stochastic Stability Equation
Authors: Boyko Vyacheslav , Vercauteren Nikki
Published: February 2024

Turbulence in very stable boundary layers is typically unsteady and intermittent. The study implements a stochastic modeling approach to represent unsteady mixing possibly associated with intermittency of turbulence and with unresolved fluid motions such as dirty waves or drainage flows. The stochastic parameterization is introduced by randomizing the mixing lengthscale used in a Reynolds average Navier‐Stokes (RANS) model with turbulent kinetic energy closure, resulting in a stochastic unsteady RANS model. The randomization alters the turbulent momentum diffusion and accounts for sporadic events of possibly unknown origin that cause unsteady mixing. The paper shows how the proposed stochastic parameterization can be integrated into a RANS model used in weather‐forecasting and its impact is analyzed using neutrally and stably stratified idealized numerical case studies. The simulations show that the framework can successfully model intermittent mixing in stably stratified conditions, and does not alter the representation of neutrally stratified conditions. It could thus present a way forward for dealing with the complexities of unsteady flows in numerical weather prediction or climate models.
The Infrared Auroral Footprint Tracks of Io, Europa and Ganymede at Jupiter Observed by Juno‐JIRAM
Authors: Moirano A. , Mura A. , Hue V. , Bonfond B. , Head L. A. , Connerney J. E. P. , Adriani A. , Altieri F. , Castagnoli C. , Cicchetti A. , Dinelli B. M. , Grassi D. , Migliorini A. , Moriconi M. L. , Noschese R. , Piccioni G. , Plainaki C. , Scarica P. , Sindoni G. , Sordini R. , Tosi F. , Turrini D. , Zambon F.
Published: February 2024

The electromagnetic coupling between the Galilean satellites at Jupiter and the planetary ionosphere generates an auroral footprint, which is detected with high spatial resolution in the infrared L band by the Jovian InfraRed Auroral Mapper (JIRAM) onboard the Juno spacecraft. We report the JIRAM data acquired since 27 August 2016 until 23 May 2022, which are used to compute the average position of the footprint tracks of Io, Europa and Ganymede. The result of the present analysis help to test the reliability of magnetic field models, to calibrate ground‐based observations and to highlight the variability in the footprint positions, which can be used to probe the plasma environment at the orbit of the satellites. The determination of the plasma properties around the moons is particularly relevant to complement the Juno flybys of the moons during its extended mission, and to support the future Juice and Europa Clipper missions. Lastly, we report no clear evidence of the auroral footprint of Callisto, which is likely due to a combination of its low expected brightness and its position very close to the main Jovian aurora.
NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells
Authors: Choi Hye Yeon , Zhu Yicheng , Zhao Xuyao , Mehta Simran , Hernandez Juan Carlos , Lee Jae-Jin , Kou Yi , Machida Risa , Giacca Mauro , Del Sal Giannino , Ray Ratna , Eoh Hyungjin , Tahara Stanley M. , Chen Lin , Tsukamoto Hidekazu , Machida Keigo
Published: February 2024

The P53-destabilizing TBC1D15-NOTCH protein interaction promotes self-renewal of tumor-initiating stem-like cells (TICs); however, the mechanisms governing the regulation of this pathway have not been fully elucidated. Here, we show that TBC1D15 stabilizes NOTCH and c-JUN through blockade of E3 ligase and CDK8 recruitment to phosphodegron sequences. Chromatin immunoprecipitation (ChIP-seq) analysis was performed to determine whether TBC1D15-dependent NOTCH1 binding occurs in TICs or non-TICs. The TIC population was isolated to evaluate TBC1D15-dependent NOTCH1 stabilization mechanisms. The tumor incidence in hepatocyte-specific triple knockout (Alb::CreERT2;Tbc1d15Flox/Flox;Notch1Flox/Flox;Notch2Flox/Flox;HCV-NS5A) Transgenic (Tg) mice and wild-type mice was compared after being fed an alcohol-containing Western diet (WD) for 12 months. The NOTCH1-TBC1D15-FIS1 interaction resulted in recruitment of mitochondria to the perinuclear region. TBC1D15 bound to full-length NUMB and to NUMB isoform 5, which lacks three Ser phosphorylation sites, and relocalized NUMB5 to mitochondria. TBC1D15 binding to NOTCH1 blocked CDK8- and CDK19-mediated phosphorylation of the NOTCH1 PEST phosphodegron to block FBW7 recruitment to Thr-2512 of NOTCH1. ChIP-seq analysis revealed that TBC1D15 and NOTCH1 regulated the expression of genes involved in mitochondrial metabolism-related pathways required for the maintenance of TICs. TBC1D15 inhibited CDK8-mediated phosphorylation to stabilize NOTCH1 and protect it from degradation The NUMB-binding oncoprotein TBC1D15 rescued NOTCH1 from NUMB-mediated ubiquitin-dependent degradation and recruited NOTCH1 to the mitochondrial outer membrane for the generation and expansion of liver TICs. A NOTCH-TBC1D15 inhibitor was found to inhibit NOTCH-dependent pathways and exhibited potent therapeutic effects in PDX mouse models. This unique targeting of the NOTCH-TBC1D15 interaction not only normalized the perinuclear localization of mitochondria but also promoted potent cytotoxic effects against TICs to eradicate patient-derived xenografts through NOTCH-dependent pathways.
Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder
Authors: Hori Hiroaki , Fukushima Hotaka , Nagayoshi Taikai , Ishikawa Rie , Zhuo Min , Yoshida Fuyuko , Kunugi Hiroshi , Okamoto Kenichi , Kim Yoshiharu , Kida Satoshi
Published: February 2024

Posttraumatic stress disorder (PTSD) is a psychiatric disorder associated with traumatic memory, yet its etiology remains unclear. Reexperiencing symptoms are specific to PTSD compared to other anxiety-related disorders. Importantly, reexperiencing can be mimicked by retrieval-related events of fear memory in animal models of traumatic memory. Recent studies revealed candidate PTSD-associated genes that were related to the cyclic adenosine monophosphate (cAMP) signaling pathway. Here, we demonstrate the tight linkage between facilitated cAMP signaling and PTSD by analyzing loss- and gain-of-cAMP signaling effects on fear memory in mice and the transcriptomes of fear memory-activated mice and female PTSD patients with reexperiencing symptoms. Pharmacological and optogenetic upregulation or downregulation of cAMP signaling transduction enhanced or impaired, respectively, the retrieval and subsequent maintenance of fear memory in mice. In line with these observations, integrative mouse and human transcriptome analysis revealed the reduced mRNA expression of phosphodiesterase 4B (PDE4B), an enzyme that degrades cAMP, in the peripheral blood of PTSD patients showing more severe reexperiencing symptoms and the mouse hippocampus after fear memory retrieval. Importantly, more severe reexperiencing symptoms and lower PDE4B mRNA levels were correlated with decreased DNA methylation of a locus within PDE4B, suggesting the involvement of methylation in the mechanism of PTSD. These findings raise the possibility that the facilitation of cAMP signaling mediating the downregulation of PDE4B expression enhances traumatic memory, thereby playing a key role in the reexperiencing symptoms of PTSD patients as a functional index of these symptoms.
Experiences of pediatric cancer patients (age 12–18 years) with extensive germline sequencing for cancer predisposition: a qualitative study
Authors: Bon Sebastian B. B. , Wouters Roel H. P. , Bakhuizen Jette J. , Jongmans Marjolijn C. J. , van den Heuvel-Eibrink Marry M. , Grootenhuis Martha A.
Published: February 2024

This study explored the experiences and needs of adolescents, ranging from 12 to 18 years old, who have recently been diagnosed with cancer and participated in a nationwide germline genetic sequencing study within the context of pediatric oncology. The 21 adolescents in this qualitative interview study viewed genetic sequencing as an integral part of their cancer journey. They often characterized germline sequencing as “good-to-know” without specifying immediate utility. While the adolescents comprehended the significance of germline genetic sequencing, they were less focused on its potential long-term implications. Adolescents expressed a strong desire to be actively engaged in decisions related to genetics. They advocated for a participatory role in genetic decision-making from a young age onwards. They recommended that re-consent should be sought before re-analysis of their genetic data is performed and believe that patients should have the opportunity to provide (re-)consent once they reach adulthood. Moreover, the adolescents emphasized the importance of developing counseling materials that are not only concise but also visually attractive. In conclusion, this study underscores the positive perception that adolescents diagnosed with cancer hold regarding germline genetic sequencing. They articulate a strong interest in being actively involved in genetic decision-making. To address these articulated needs and preferences, we recommend the development of visually engaging counseling materials. These materials should effectively convey both the immediate and long-term implications of genetic sequencing, enabling adolescents with cancer to make informed decisions about genetic sequencing.
Location selection for offshore wind power station using interval-valued intuitionistic fuzzy distance measure-RANCOM-WISP method
Authors: Rani Pratibha , Mishra Arunodaya Raj , Cavallaro Fausto , Alrasheedi Adel Fahad
Published: February 2024

The development opportunities and high-performance capacity of offshore wind energy project depends on the selection of the suitable offshore wind power station (OWPS) location. The present study aims to introduce a decision-making model for assessing the locations for OWPS from multiple criteria and uncertainty perspectives. In this regard, the concept of interval-valued intuitionistic fuzzy set (IVIFS) is utilized to express uncertain information. To quantify the degree of difference between IVIFSs, an improved distance measure is proposed and further utilized for deriving the objective weights of criteria. Numerical examples are discussed to illustrate the usefulness of introduced IVIF-distance measure. The RANking COMparison (RANCOM) based on interval-valued intuitionistic fuzzy information is presented to determine the subjective weights of criteria. With the combination of objective and subjective weights of criteria, an integrated weighting tool is presented to find the numeric weights of criteria under IVIFS environment. Further, a hybrid interval-valued intuitionistic fuzzy Weighted integrated Sum Product (WISP) approach is developed to prioritize the OWPS locations from multiple criteria and uncertainty perspectives. This approach combines the benefits of two normalization tools and four utility measures, which approves the effect of beneficial and non-beneficial criteria by means of weighted sum and weighted product measures. Further, the developed approach is applied to the OWPS location selection problem of Gujarat, India. Sensitivity and comparative analyses are presented to confirm the robustness and stability of the present WISP approach. This study provides an innovative decision analysis framework, which makes a significant contribution to the OWPS locations assessment problem under uncertain environment.
Association of tissue oxygen saturation levels with skeletal muscle injury in the critically ill
Authors: Sugiya Ryuji , Arizono Shinichi , Higashimoto Yuji , Kimoto Yuta , Shiraishi Masashi , Mizusawa Hiroki , Tawara Yuichi , Shigeoka Hironori , Bakker Jan , Shinozaki Koichiro
Published: February 2024

This study aimed to investigate the association between the level of tissue oxygen saturation (StO2) and quadriceps/skeletal muscle dysfunction, measured using the Medical Research Council (MRC) scale and ultrasonography, in critically ill patients. Thirty-four patients hospitalized at the Critical Care Medicine Center of Kindai University Hospital, between January 2022 and March 2023, were enrolled in this study. The StO2 of the quadriceps muscle was measured via near-infrared spectroscopy. Muscle atrophy was measured by the thickness, cross-sectional area (CSA), and echo intensity of the rectus femoris (RF). These values were evaluated every alternate day until 13 days after admission or until discharge, whichever occurred first. Muscle weakness was assessed using the sum score of the MRC scale (MRC-SS), with the patient sitting at bedside. The mean age of the patients was 67.3 ± 15.3 years, and 20 (59%) were men. Seven patients (21%) were admitted for trauma, and 27 (79%) were admitted for medical emergencies or others. The mean score for the MRC-SS was 51.0 ± 7.9 points. RF thickness and CSA significantly decreased after day 7 (p < 0.05). There were no significant changes in StO2 levels during hospitalization. However, there were positive correlations between the nadir StO2 during hospitalization and MRC-SS, and changes in RF thickness and CSA at discharge (r = 0.41, p = 0.03; r = 0.37, p = 0.03; and r = 0.35, p = 0.05, respectively). StO2 in the quadriceps muscle may be useful for predicting muscle atrophy and dysfunction in patients with critical illnesses.
The value of five scoring systems in predicting the prognosis of patients with sepsis-associated acute respiratory failure
Authors: Fan Shiqin , Ma Jing
Published: February 2024

Our study aimed to identify the optimal scoring system for predicting the prognosis of patients with sepsis-associated acute respiratory failure (SA-ARF). All data were taken from the fourth version of the Markets in Intensive Care Medicine (MIMIC-IV) database. Independent risk factors for death in hospitals were confirmed by regression analysis. The predictive value of the five scoring systems was evaluated by receiving operating characteristic (ROC) curves. Kaplan‒Meier curves showed the impact of acute physiology score III (APSIII) on survival and prognosis in patients with SA-ARF. Decision curve analysis (DCA) identified a scoring system with the highest net clinical benefit. ROC curve analysis showed that APS III (AUC: 0.755, 95% Cl 0.714–0.768) and Logical Organ Dysfunction System (LODS) (AUC: 0.731, 95% Cl 0.717–0.7745) were better than Simplified Acute Physiology Score II (SAPS II) (AUC: 0.727, 95% CI 0.713–0.741), Oxford Acute Severity of Illness Score (OASIS) (AUC: 0.706, 95% CI 0.691–0.720) and Sequential Organ Failure Assessment (SOFA) (AUC: 0.606, 95% CI 0.590–0.621) in assessing in-hospital mortality. Kaplan‒Meier survival analysis patients in the high-APS III score group had a considerably poorer median survival time. The DCA curve showed that APS III may provide better clinical benefits for patients. We demonstrated that the APS III score is an excellent predictor of in-hospital mortality.
The human PTGR1 gene expression is controlled by TE-derived Z-DNA forming sequence cooperating with miR-6867-5p
Authors: Lee Du Hyeong , Bae Woo Hyeon , Ha Hongseok , Kim Woo Ryung , Park Eun Gyung , Lee Yun Ju , Kim Jung-min , Shin Hae Jin , Kim Heui-Soo
Published: February 2024

Z-DNA, a well-known non-canonical form of DNA involved in gene regulation, is often found in gene promoters. Transposable elements (TEs), which make up 45% of the human genome, can move from one location to another within the genome. TEs play various biological roles in host organisms, and like Z-DNA, can influence transcriptional regulation near promoter regions. MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that play a critical role in the regulation of gene expression. Although TEs can generate Z-DNA and miRNAs can bind to Z-DNA, how these factors affect gene transcription has yet to be elucidated. Here, we identified potential Z-DNA forming sequence (ZFS), including TE-derived ZFS, in the promoter of prostaglandin reductase 1 (PTGR1) by data analysis. The transcriptional activity of these ZFS in PTGR1 was confirmed using dual-luciferase reporter assays. In addition, we discovered a novel ZFS-binding miRNA (miR-6867-5p) that suppressed PTGR1 expression by targeting to ZFS. In conclusion, these findings suggest that ZFS, including TE-derived ZFS, can regulate PTGR1 gene expression and that miR-6867-5p can suppress PTGR1 by interacting with ZFS.
Survival analysis of early intention of antenatal care among women in Bangladesh
Authors: Hossain Md. Ismail , Rahman Tanjima , Sadia Tahsin Shams , Saleheen Ahmed Abdus Saleh , Sarkar Shuvongkar , Khan Maruf , Ohi Tahsina Fariha , Haq Iqramul
Published: February 2024

This study focuses on the importance of early and regular Antenatal Care (ANC) visits in reducing maternal and child mortality rates in Bangladesh, a country where such health indicators are a concern. The research utilized data from the Bangladesh Demographic and Health Survey (BDHS) conducted in 2017–18 and employed the Cox proportional hazard model to identify factors influencing women’s intention of ANC services. The results revealed that 40.4% of women engaged in at least one ANC activity during the first trimester, which, although higher than in other countries, falls below the global average. Notably, women between the aged of 25 and 29 years took 15% less time for their first ANC visit compared to their younger counterparts, suggesting higher awareness and preparedness in this age group. Education, both for women and their partners, had a significant influence on the intention to visit ANC early. Women in the poor wealth quantile exhibited lower odds of seeking timely ANC, whereas those with a planned pregnancy were more likely to do so. Moreover, access to mass media decreased the timing of ANC visits by 26% compared to women who were not exposed. Moreover, living in rural areas was linked to a 17% delay in the timing of the first ANC visit compared to urban areas. These findings underscore the importance of addressing these determinants to improve the timeliness and accessibility of ANC services, thereby enhancing maternal and child health outcomes in Bangladesh.
SiamFDA: feature dynamic activation siamese network for visual tracking
Authors: Gu Jialiang , She Ying , Yang Yi
Published: February 2024

In this paper, we present a novel anchor-free visual tracking framework, referred to as feature dynamic activation siamese network (SiamFDA), which addresses the issue of ignoring global spatial information in current Siamese network-based tracking algorithms. Our approach captures long-range dependencies between distant pixels in space, which enables robustness to unreliable regions. Additionally, we introduce a hierarchical feature selector that adaptively activates features at different layers, and an adaptive sample label assignment method to further improve tracking performance. Our extensive evaluations on six benchmark datasets, including VOT-2018, VOT-2019, GOT10k, LaSOT, OTB-2015, and OTB-2013, demonstrate that SiamFDA outperforms several state-of-the-art trackers in various challenging scenarios, with a real-time frame rate of 40 frames per second.
Relationship between time-weighted average glucose and mortality in critically ill patients: a retrospective analysis of the MIMIC-IV database
Authors: Feng Mengwen , Zhou Jing
Published: February 2024

Blood glucose management in intensive care units (ICU) remains a controversial topic. We assessed the association between time-weighted average glucose (TWAG) levels and ICU mortality in critically ill patients in a real-world study. This retrospective study included critically ill patients from the Medical Information Mart for Intensive Care IV database. Glycemic distance is the difference between TWAG in the ICU and preadmission usual glycemia assessed with glycated hemoglobin at ICU admission. The TWAG and glycemic distance were divided into 4 groups and 3 groups, and their associations with ICU mortality risk were evaluated using multivariate logistic regression. Restricted cubic splines were used to explore the non-linear relationship. A total of 4737 adult patients were included. After adjusting for covariates, compared with TWAG ≤ 110 mg/dL, the odds ratios (ORs) of the TWAG > 110 mg/dL groups were 1.62 (95% CI 0.97–2.84, p = 0.075), 3.41 (95% CI 1.97–6.15, p < 0.05), and 6.62 (95% CI 3.6–12.6, p < 0.05). Compared with glycemic distance at − 15.1–20.1 mg/dL, the ORs of lower or higher groups were 0.78 (95% CI 0.50–1.21, p = 0.3) and 2.84 (95% CI 2.12–3.82, p < 0.05). The effect of hyperglycemia on ICU mortality was more pronounced in non-diabetic and non-septic patients. TWAG showed a U-shaped relationship with ICU mortality risk, and the mortality risk was minimal at 111 mg/dL. Maintaining glycemic distance ≤ 20.1 mg/dL may be beneficial. In different subgroups, the impact of hyperglycemia varied.
Research on mechanical properties of concrete by nano-TiC-BF-fly ash
Authors: Yang Xin , Yu Kui , Li Ke , Wang Zhengjun , Ji Fengchun , Li Mengyuan
Published: February 2024

Ultra-high-rise buildings require high concrete bearing capacity. Ordinary concrete often fails to meet the project requirements. Admixture of admixtures in concrete is a means of solution. Currently, studies on the incorporation of basalt fiber (BF) and fly ash (FA) in concrete are relatively mature. However, research on incorporating nano-Titanium Carbide (nano-TiC) in concrete is still relatively scarce, which has a lot of room for development. To further improve the mechanical properties of concrete, BF, and FA synergized with nano-TiC were incorporated into concrete to produce TBF concrete in this study. And Response Surface Methodology (RSM) was used to optimize the mechanical properties of concrete. The collapse and compressive deformation damage characteristics of concrete were analyzed. The microstructure of the cement matrix was analyzed by the SEM (Scanning Electron Microscope). An optimization model of the TBF concrete craving function was developed. Optimized ratios with compressive, split tensile, and flexural strengths as response objectives were obtained, and the accuracy of the optimized ratios was investigated using the same experimental conditions. The results of the study showed that FA increased the collapse of concrete, while nano-TiC and BF decreased the collapse of concrete. Under uniaxial compression, nano-TiC, FA, and BF together incorporated into concrete can improve its compressive damage state. Moderate amounts of nano-TiC, BF, and FA could improve the mechanical properties of concrete. Their optimal mixing ratio admixtures were 0.88%, 0.24%, and 5.49%, respectively. And the measured values under the same conditions were compared with the predicted values. The maximum difference in compressive strength was 6.09%. The maximum difference in split tensile strength was 7.14%. The maximum difference in flexural strength was 8.45%. This indicated that the accuracy of the RSM optimization model was good. A moderate amount of nano-TiC, FA, and BF could improve the densification of concrete.
Rewiring of the phosphoproteome executes two meiotic divisions in budding yeast
Authors: Koch Lori B , Spanos Christos , Kelly Van , Ly Tony , Marston Adele L
Published: February 2024

The cell cycle is ordered by a controlled network of kinases and phosphatases. To generate gametes via meiosis, two distinct and sequential chromosome segregation events occur without an intervening S phase. How canonical cell cycle controls are modified for meiosis is not well understood. Here, using highly synchronous budding yeast populations, we reveal how the global proteome and phosphoproteome change during the meiotic divisions. While protein abundance changes are limited to key cell cycle regulators, dynamic phosphorylation changes are pervasive. Our data indicate that two waves of cyclin-dependent kinase (Cdc28Cdk1) and Polo (Cdc5Polo) kinase activity drive successive meiotic divisions. These two distinct phases of phosphorylation are ensured by the meiosis-specific Spo13 protein, which rewires the phosphoproteome. Spo13 binds to Cdc5Polo to promote phosphorylation in meiosis I, particularly of substrates containing a variant of the canonical Cdc5Polo motif. Overall, our findings reveal that a master regulator of meiosis directs the activity of a kinase to change the phosphorylation landscape and elicit a developmental cascade.
Enantioselective C–H bond functionalization under Co(iii)-catalysis
Authors: Garai Bholanath , Das Abir , Kumar Doppalapudi Vineet , Sundararaju Basker
Published: February 2024

Enantioselective C–H functionalization relies on 4d and 5d metals, but with their depletion, sustainable alternatives using 3d metals are crucial.
Metal–organic polyhedron from a flexible tetrakis(thiobenzyl-carboxylate)-tetrathiafulvalene
Authors: Cheret Yohan , Avarvari Narcis , Zigon Nicolas
Published: February 2024

Wiggle, wiggle… Stay! A redox-active tetrakis(thiobenzyl-carboxylate)-TTF with a high degree of flexibility stands still in a self-assembled cage upon complexation with Cu(ii).
Infrared spectra and electronic structural changes of DNTF under high pressure: experimental and theoretical studies
Authors: Nan Hai , Su Haipeng , Chen Chunyan , Bu Yufan , Niu Guotao , Sun Peipei , Shen Fei , Wang Xuanjun
Published: February 2024

The experimental infrared spectra of DNTF below 800 cm−1 are mainly contributed by mixing of the bending, torsion and out-of plane vibration of furoxan rings and furazan rings.
Varying the degree of oxidation of graphite: effect of oxidation time and oxidant mass
Authors: Karnis Ioannis , Krasanakis Fanourios , Sygellou Labrini , Rissanou Anastassia N. , Karatasos Konstantinos , Chrissopoulou Kiriaki
Published: February 2024

XRD measurements of graphene oxides oxidized with varying oxidant masses demonstrate a systematic increase in their interlayer distance; the snapshot corresponds to one of the experimental systems that was obtained through MD simulations.
A new charge transfer pathway in the MoSe2–WSe2 heterostructure under the conditions of B-excitons being resonantly pumped
Authors: Hu Zifan , Wang Hai , Wang Lei , Wang Haiyu
Published: February 2024

Using a broadband transient pump–probe absorption technique, we have discovered a novel charge transfer pathway associated with the high-energy state corresponding to the B-exciton in the MoSe2–WSe2 heterostructure.
Au9 nanocluster adsorption and agglomeration control through sulfur modification of mesoporous TiO2
Authors: Motamedisade Anahita , Johnston Martin R. , Alotaibi Amjad E.H. , Andersson Gunther A.
Published: February 2024

In the present work, phenyl phosphine-protected Au9 nanoclusters were deposited onto (3-mercaptopropyl) trimethoxysilane (MPTMS) modified and unmodified mesoporous screen printed TiO2. Agglomeration and adsorption of Au clusters were explored using XPS.
A triple Fano resonance Si–graphene metasurface for multi-channel tunable ultra-narrow band sensing
Authors: Liu Jukun , Dai Hongxiang , Ju Jiaqi , Cheng Ke
Published: February 2024

In this work, a dielectric metasurface composed of a silicon nanodisk etched with a square hole is proposed.
Opposing roles of organic salts on mini-protein structure
Authors: Lee Pei-Yin , Singh Onkar , Nanajkar Neha , Bermudez Harry , Matysiak Silvina
Published: February 2024

Exploring impact of [EMIM][Cl] and [Chol][Cl] on Trp-cage and Trpzip4 mini-proteins' environments and structures using computational and experimental methods.
Self-assembly mechanism, physicochemical analyses and application performance investigations of branched alkyl glycosides with alcohol ether carboxylic acids of varied epoxide numbers
Authors: Wang Yukai , Zhang Zhihui , Bai Liang , Yang Xiuquan , Qi Yunqin , Li Jiahao , Zhou Yuan , Wu Zhiyu , Qin Ziyu
Published: February 2024

Alkyl glycosides and fatty alcohol ether carboxylic acids, are known for their biocompatibility, multiresponsiveness, and versatile applications, garnering significant attention in the realms of green and colloid chemistry.
Pressure and temperature dependent kinetics and the reaction mechanism of Criegee intermediates with vinyl alcohol: a theoretical study
Authors: Sun Cuihong , Xu Baoen , Zeng Yanli
Published: February 2024

The 1,4-insertion is the main channel for the CH2OO + syn-VA reaction, while the cycloaddition is more competitive in the CH2OO + anti-VA reaction. The dissociation products involving OH radicals are formed at higher temperature and lower pressure.
One-step sintering construction of electromagnetic synergistic Co7Fe3/Co@CBC nanocomposites for enhanced microwave absorption properties
Authors: Zhao Yunmin , Su Shunlin , Liu Zhilong , Ren Jianxin , Wang Lihong , Wang Yude
Published: February 2024

Based on the synergistic modulation of electromagnetic parameters and microstructure design, multidimensional porous magnetic carbon-based nanocomposites have become ideal materials with efficient absorption properties.
Re(i)[2-aryl-1H-imidazo[4,5-f][1,10]phenanthroline] tricarbonyl chloride complexes for selective cancer therapy via a potential DNA damage mechanism
Authors: Babu Lavanya Thilak , Das Utpal , Das Rishav , Kar Binoy , Paira Priyankar
Published: February 2024

Rhenium (i)-based 2-arylimidazopenantroline tricarbonyl complexes show potential for cancer treatment via G2/M phase cell-cycle arrest in association with the generation of reactive oxygen species (ROS).
Does trapped O2 form in the bulk of LiNiO2 during charging?
Authors: Juelsholt Mikkel , Chen Jun , Pérez-Osorio Miguel A. , Rees Gregory J. , De Sousa Coutinho Sofia , Maynard-Casely Helen E. , Liu Jue , Everett Michelle , Agrestini Stefano , Garcia-Fernandez Mirian , Zhou Ke-Jin , House Robert A. , Bruce Peter G.
Published: February 2024

The charge storage mechanism in LiNiO2 in Li-ion batteries is still under debate. Here, we show that trapped O2 forms during delithiation in LiNiO2, accommodated by Ni vacancies, which form in the Ni layer.
Solvent-free aerobic photocatalytic oxidation of C(sp3)–H and C(sp3)–OH to CO bonds
Authors: Jiang Xulu , Wang Weitao , Wang Huan , He Zhen-Hong , Yang Yang , Wang Kuan , Liu Zhao-Tie , Han Buxing
Published: February 2024

Solvent-free aerobic photocatalytic oxidation of benzylic C(sp3)–H and C(sp3)–OH to CO bonds.
Valorization of polycaprolactone for the production of nylon-6 monomers
Authors: Zhang Hui , Zhao Yanfei , Wang Yusi , Li Rongxiang , Tang Minhao , Zeng Wei , Wang Ying , Chang Xiaoqian , Han Buxing , Liu Zhimin
Published: February 2024

A one-pot approach is presented to upgrade PCL into nylon-6 monomers (EACA and CPL) over Ru catalysts, affording products in a total yield of EACA and CPL up to 90.2%.
Flow techniques in the analysis of biological samples by inductively coupled plasma mass spectrometry – a review
Authors: Kowa Ewelina , Telk Anna , Wieczorek Marcin
Published: February 2024

Our work presents numerous examples where coupling flow techniques with ICP-MS enabled obtaining promising results in biological sample analyses. Yet, such a connection is not commonly applied, and we hope to encourage scientists to benefit from it.
Deciphering fibroblast-induced drug resistance in non-small cell lung carcinoma through patient-derived organoids in agarose microwells
Authors: Luan Qiyue , Pulido Ines , Isagirre Angelique , Carretero Julian , Zhou Jian , Shimamura Takeshi , Papautsky Ian
Published: February 2024

Agarose microwell platform for modeling lung carcinoma using patient-derived tissues to decipher cancer associated fibroblast-induced drug resistance.
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides
Authors: Chekan Jonathan R. , Mydy Lisa S. , Pasquale Michael A. , Kersten Roland D.
Published: February 2024

Plant peptide natural products are ribosomally synthesized and post-translationally modified peptides (RiPPs). We review structure, biosynthesis, and bioactivity of plant RiPPs and define burpitides, a recent addition to plant RiPP classes.
Opportunities and challenges of RiPP-based therapeutics
Authors: Pfeiffer Isabel P.-M. , Schröder Maria-Paula , Mordhorst Silja
Published: February 2024

Ribosomally synthesised and post-translationally modified peptides (RiPPs) are highly promising candidates for drug discovery and development, but challenges remain.
Rational design and easy fabrication of transparent photothermal/hygroscopic composite coatings with long-lasting antifogging performance under sunlight activation
Authors: Ma Jinyue , Gu Xiuxian , He Junhui
Published: February 2024

Preparation of novel photothermal/hygroscopic dual-layer coatings integrating active and passive mechanisms towards achieving long-lasting antifogging performance.
AI in computational chemistry through the lens of a decade-long journey
Authors: Dral Pavlo O.
Published: February 2024

AI-enhanced computational chemistry methods such as AIQM1 break through the limitations of the traditional quantum chemistry.
Development of a novel Ba2BiV3O11 photocatalyst with dual functions of both water oxidation and proton reduction performance
Authors: Du Xuejiao , Xing Mingxue , Xu Yang , Zhao Conghui , Feng Zhaochi , Dong Beibei
Published: February 2024

A novel bismuth-based Ba2BiV3O11 photocatalyst with dual functions of H2 and O2 evolution reactions.
Plasma-induced nitrogen vacancy-mediated ammonia synthesis over a VN catalyst
Authors: Luo Shijian , Liu Yongduo , Song Yang , Yang Yuran , Chen Fadong , Chen Siguo , Wei Zidong
Published: February 2024

A highly active VN catalyst for plasma-catalytic NH3 synthesis via the unique Mars–van Krevelen (MvK) mechanism.
Small-size and well-dispersed Fe nanoparticles embedded in carbon rods for efficient oxygen reduction reaction
Authors: Duan Xinde , Ge Fayuan , Liu Yang , Zheng Hegen
Published: February 2024

Using a “vapor adsorption” strategy, uniform carbon-protected metal (Fe and Zn) NPs (7 nm) have been successfully prepared. Significantly, this catalyst exhibits wonderful ORR activity in 0.1 M KOH and much better E1/2 of 0.868 V (vs. RHE).
Concise total synthesis of (−)-berkelic acid via regioselective spiroacetal/pyran formation
Authors: Hanada Shogo , Yoshida Masahito , Kigoshi Hideo
Published: February 2024

Concise total synthesis of (−)-berkelic acid is accomplished through regioselective tandem spiroacetal/pyran formation of a simpler alkyne precursor.
Photoredox-catalyzed unsymmetrical diamination of alkenes for access to vicinal diamines
Authors: Liu Jie , Guo Lu , Chen Zhang , Guo Yu , Zhang Wei , Peng Xue , Wang Zhen , Zeng Yao-Fu
Published: February 2024

Unsymmetrical vicinal diamines have been achieved via the photoredox-catalyzed difunctionalization of alkenes by using N-aminopyridinium salts and nitriles as the amination reagents, respectively.
Carbon nitride nanosheet-supported CuO for efficient photocatalytic CO2 reduction with 100% CO selectivity
Authors: Lv Xingxi , You Xiaomeng , Pang Jingyi , Zhou Hang , Huang Zejiang , Yao Ye-Feng , Wang Xue-Lu
Published: February 2024

The hydrogen bond network strength of the reaction solution is regulated to achieve high performance and 100% selectivity.
Bioinspired photoelectrochemical NADH regeneration based on a molecular catalyst-modified photocathode
Authors: Chen Meng , Liu Fengyu , Wu Yizhou , Li Yingzheng , Liu Chang , Zhao Ziqi , Zhang Peili , Zhao Yilong , Sun Licheng , Li Fusheng
Published: February 2024

Photoelectrochemical NADH regeneration was achieved by a photocathode modified by an electron transport mediator and a catalyst.
1D Pb halide perovskite-like materials for high performance X-ray detection
Authors: Wang Jing , Yang Jin-Hai , Chen Jie , Wang Shuai-Hua , Chen Yong-Jun , Xu Gang
Published: February 2024

A series of 1D Pb halide perovskite-like materials with a tunable bandgap were fabricated and exhibit excellent X-ray detection performance.
Consequences of twisting of the flexible arms of imidazole-derived urea in zinc-dicarboxylate coordination polymers
Authors: Verma Satyendra , Brahma Rinki , Baruah Jubaraj B.
Published: February 2024

A semi-flexible imidazole-based urea ligand, 1-(3-(1H-imidazol-1-yl)propyl)-3-phenylurea, and three zinc-dicarboxylate coordination polymers possessing the ligand were synthesized and characterized.
A facile synthesis of a Ce-based MOF at room temperature for effective adsorption of methylene blue
Authors: Zhou Yang , Wang Dan , Feng Qiuxiang , Wu Qi , Cao Feng , Jiang Li , Zhang Qianli , Liu Jie
Published: February 2024

Ce-UiO-66-NH2 was synthesized in water and ethanol at room temperature for effective removal of MB in aqueous solution.