bluuebunny/crossref_metadata_2025 huggingface dataset:
Literární paměť a region Úvod
Authors: Schupplerová Stanislava
Published: November 2021

The article deals with region of Jeseníky, its representation in Czech prose written after 1945. Emphasis is placed on two themes — on term of region and on reflection the term in literature and memory of literature. We try to explain term of region and in second part we analyse prosaic texts, which thematize this area, therefore region of Jeseníky. Our interest is focused on these Czech authors — Vladimír Körner, Josef Urban, Jaroslav Rudiš, Jaromír Švejdík.
Aplicación de teorías no locales en el análisis de vigas cantiléver y continua mediante el método de los elementos finitos
Authors:   , Garbin Turpaud Fernando , Lévano Pachas Ángel Alfredo
Published: November 2021

En el presente estudio, se propone un análisis lineal de Elementos Finitos de vigas cantiléver y continuas bajo un enfoque no local mediante la Teoría de Primera Deformación Por Corte (FSDT), la cual permita desarrollar de mejor manera el análisis de los efectos de corte (esfuerzos y deformaciones) que ocurren en la sección transversal de la viga. En primer lugar, se define el campo de desplazamientos correspondiente a la Teoría FSDT logrando, mediante expansión de Taylor, una aproximación cuadrática del componente de desplazamiento en el eje z. Luego, se define con aproximación lineal el campo de deformaciones. Posteriormente, se plantea el Principio de los Trabajos Virtuales para desarrollar la formulación débil correspondiente a la Teoría FSDT, introduciendo los modelos de elementos finitos por cada parámetro desconocido, tomando en cuenta que el grado de las funciones de aproximación. Se realizan casos de estudio y se analizan los resultados.
PERSPEKTIF POLITICAL JUSTICE DI DALAM IMPLEMENTASI BPJS PBI DI KOTA SURABAYA
Authors: Nabilah Tamy Nur , Nugroho Kris
Published: November 2021

This study discusses the perspective of Political Justice in the Implementation of BPJS PBI in Surabaya. The study aims to determine the implementation of BPJS PBI in Surabaya has fulfilled Political Justice and the implementation of BPJS PBI in Surabaya is adequate as a form of political justice. The research method that uses is descriptive qualitative because it presents a detailed description of the situation or social phenomenon. Methods of data collection using direct interviews with resource persons include: Head of Surabaya City Health Office, Surabaya City DPRD Commission D, Lurah, PBJS recipient community. The results showed that the implementation of BPJS PBI in Surabaya City had not yet fulfilled Political Justice, based on indicators of fairness, equality, equality, and impartiality. The implementation of BPJS PBI in the city of Surabaya is also inadequate as a form of political justice because the state still determines justice in terms of profit and loss to health because the way of thinking lies in the amount of current contributions that do not match the actual calculation. Therefore, the implementation of the Health Insurance for the Poor program funded by the Surabaya City Regional Budget has not yet fulfilled the concept of Political Justice. This can be seen that there are still Health Insurance recipients who are not on target because of lack of accuracy in the process of verifying data on the poor in Surabaya, easy to get a Poor Certificate (SKM) that applies only once, and there are still groups of welfare recipients, so there is no meet the aspects of equity and justice.
STRATEGI PEMENANGAN CALEG PARTAI GERINDRA DALAM PEMILU LEGISLATIF 2019: STUDI KASUS BAMBANG PUJIANTO DAPIL 2 SIDOARJO
Authors: Widiowati Bintang , Pramutanto Wisnu
Published: November 2021

The present study discusses the strategy of winning the Gerindra party candidates in Sidoarjo. In this case the problem that occurs is the struggle for the seat of Si- doarjo regency DPRD. In this thesis the researcher will explain the winning strat- egies, challenges and obstacles during the campaign process of the Gerindra party candidates. Seeing within the framework of the theory of Firmanzah which states that political marketing is divided into 4 programs (4P) namely: Product, Promo- tion, Price, Place. In this research, it will be seen how the winning strategy carried out by the Gerindra party candidates (Bambang Pudjianto) in electoral districts 2 of Sidoarjo regency, where he is an incumbent candidate who has advanced as a people's representative. His strategy is to rely on 3 products of political jargon; # win us, the medical check-up program and aspiration stalls that reap the enthusias- tic response of citizens. With the strategy carried out by Bambang Pudjianto, he succeeded in attracting the sympathy of the people so that he was re-elected as the sidoarjo district parliament.
KEADILAN ELEKTORAL BAGI PEMILIH PENYANDANG DISABILITAS MENTAL PADA PEMILU SERENTAK 2019 DI SURABAYA
Authors: Desverose Nikita , Priyatmoko Priyatmoko
Published: November 2021

This research focuses on upholding political justice in elections for mentally disabled people, more precisely about how the state and its institutions seek to restore political rights and implement inclusive election policies for person with mental disabilities regarding their participation in elections and their right to vote when election. This research takes two main topics, namely restoration of political rights of mentally disabled people in elections through the regulation of the Election Law, and the making of special rules to accommodate the needs of mental disabled people in elections and the implementation of these policies in the 2019 elections in the city of Surabaya. Data obtained through the analysis of news content and interviews with sources that are then processed and explained qualitatively descriptive. The theory used in this research is electoral justice theory, with a focus on conformity in the field with elements of justice in the electoral justice system. The results obtained are in the first part, the regulation carried out by the government based on complaints from community organizations that focus on defending mental disability rights and electoral issues, meets the criteria for fulfilling rights and distributing justice first where the state gives equal rights for everyone to channel their voice in elections, without discriminating any group by giving them access to the right to be registered as DPT and entitled to participate in the election process. In the second part, it discussed the implementation of the policy in the city of Surabaya, specifically at the Menur Hospital and found that the state tried to accommodate the political rights of the mentally disabled in elections by providing more specific technical rules by adjusting the conditions and needs of the mentally disabled, which according to the elements election justice which requires electoral governance to protect citizens' voting rights. The final conclusion of this study illustrates how the state and its institutions fulfill the elements of the electoral justice system in distributing justice in elections, for people with mental disabilities in Indonesia, especially in the city of Surabaya in the 2019 Elections.
Digitalization in the Accounting and Auditing Profession through ERP Systems
Authors:   The Bucharest University of Economic Studies, Romania, Ionescu Bogdan Stefan , Barna Laura Eugenia Lavinia ,   The Bucharest University of Economic Studies, Romania
Published: November 2021

The objective of this paper is to observe the possibility of digitizing the accounting and auditing profession by implementing ERP systems, as a result of massive changes in technology over time. The purpose of this paper is to add value to the literature, given the positive or negative aspects of the digitization of the accounting and auditing profession using information systems such as ERP. ERP systems such as information systems have a key role in managing and conducting accounting and auditing, providing support to professional accountants and auditors. The research method used to identify the possibility of digitizing the accounting and auditing profession through ERP information systems is based on the analysis of the archive (literature review), collecting data and information from selected articles from different databases. Following the study, the authors concluded that the accounting and auditing profession can be digitized through the use of ERP information systems, as it allows the automation of a large number of tasks, and the information processed with these systems is much more transparent and accurate.
ACTINOBACTERIAS DEGRADADORAS DE POLIPROPILENO
Authors: Boenel Micaela , Vobis Gernot , Solans Mariana
Published: November 2021

La acumulación de polímeros sintéticos es un gran problema de contaminación ambiental, ya que no existen métodos eficientes para su eliminación segura; sin embargo, hay evidencias sobre su degradación por actinobacterias. En este trabajo se evaluó la capacidad de degradación de actinobacterias aisladas de suelo del vertedero de Bariloche, sobre tres biopolímeros y un polímero sintético. Por un lado, se estudió la degradación de polímeros naturales (almidón, hemicelulosa, celulosa) en medio sólido, y por otro el otro se evaluó la degradación de láminas de polipropileno inoculadas con los aislamientos y cultivadas en medio líquido durante seis semanas a 37 ºC. Luego se midió la pérdida de peso en las láminas y se estudió la colonización de la superficie del polipropileno mediante microscopia óptica y electrónica. Los datos fueron analizados con un ANOVA de dos vías y la prueba de Tukey. De los 35 aislamientos totales, el 88 % correspondió al género Streptomyces y el 3 % a los demás géneros (Actinomadura, Pseudonocardia, Saccharomonospora y Thermoactinomyces). El 63 % de los aislamientos tuvo la capacidad de degradar almidón, el 86 % hemicelulosa, el 34 % celulosa microcristalina (exoglucanasas) y el 88 % carboximetilcelulosa (endoglucanasas). Se observó colonización de la superficie de polipropileno en todos los tratamientos. Dos de las cepas estudiadas (Streptomyces sp. MP32 y Actinomadura sp. MP5) redujeron el peso de las láminas de polipropileno (p ≤ 0.05). Estos resultados preliminares muestran la capacidad de las actinobacterias para colonizar la superficie del polipropileno, con potencial uso en suelos o ambientes contaminados por plásticos.
TROPHIC STATUS OF A TROPICAL COASTAL LAGOON IN MARGARITA ISLAND, VENEZUELA
Authors: Pereira-Ibarra Carlos Julio , López-Monroy Fabiola
Published: November 2021

Punta de Piedras Lagoon is a coastal lagoon located south of Margarita Island, in the Venezuelan Caribbean Sea. This lagoon has ecological and economic importance for the inhabitants of nearby communities. Currently, the urban and industrial development in its surroundings represents a potential source of pollutants, providing concentrations of nutrients that could affect the ecological balance of the area. The trophic status of Punta de Piedras Lagoon was evaluated using various trophic indices. The concentrations of chlorophyll-a and nutrients (ammonium, nitrites, nitrates, and orthophosphates) were estimated in 10 stations with a monthly frequency from February 2005 to January 2006. These data were used to estimate the trophic condition based on the Karydis and TRIX trophic indices, and by comparison with Organization for Economic Co-operation and Development reference values. It was found that Punta de Piedras lagoon presented mesotrophic conditions in most of the water body having considerable differences between indices. The values of the closest station to Paseo Esther Gil corresponded to eutrophic waters. However, the circulation and residence time of water allow an exchange with the adjacent sea, which prevents the eutrophication process in the lagoon.
Biomass Burning and Gas Flares Create the Extreme West African Aerosol Plume Which Perturbs the Hadley Circulation and Thereby Changes Europe’s Winter Climate
Authors: Potts Keith A.
Published: November 2021

Three significant changes have occurred in the winter climate in Europe recently: increased UK flooding; Iberian drought; and warmer temperatures north of the Alps. The literature links all three to a persistent, significant increase in sea level pressure over Southern Europe, the Medi-terranean, Iberia and the Eastern Atlantic (SEMIEA) which changes the atmospheric circulation system: forcing cold fronts to the north away from Iberia; and creating a south westerly flow around the northern perimeter of the high-pressure region bringing warmer, moist air from the subtropical Atlantic to the UK and Europe which increases precipitation in the UK and raises the temperature in Europe. I use the Last Millennium Ensemble, MERRA-2 and Terra-NCEP data to demonstrate that the extreme, anthropogenic, West African aerosol Plume (WAP) which only exists from December to April perturbs the northern, regional Hadley Circulation creating the high pressure in the SEMIEA. I also show that the anthropogenic WAP has only existed in its extreme form in recent decades as the two major sources of the WAP aerosols: biomass burning; and gas flaring have both increased significantly since 1950 due to: a four-fold increase in population; and gas flaring rising from zero to 7.4 billion m3/annum and note that this time span coincides with the changes in the three elements of the winter climate of Europe. I also suggest that it may be possible to eliminate the WAP and return the winter climate of Europe to its natural state after the crucial first step of recognising the cause of the changes is taken.
Root-To-Shoot Signaling for the Coding of Support Thickness in Pea Plants
Authors: Guerra Silvia , Bonato Bianca , Wang Qiuran , Peressotti Alessandro , Peressotti Francesca , Baccinelli Walter , Bulgheroni Maria , Castiello Umberto
Published: November 2021

Plants characterized by a soft or weak steam, such as climbing plants, need to find a potential support (e.g., wooden trunk) to reach greater light exposure. Since Darwin’s research on climbing plants, several studies on their searching and attachment behaviors have demonstrated their unique ability to process different support features to modulate their movements accordingly. Nevertheless, the strategies underlying this ability are yet to be uncovered. The present research tries to fill this gap by investigating how the interaction between above- (i.e., stem, tendril, …) and belowground (i.e., the root system) plant organs influence the kinematics of the approach-to-grasp movement. With three-dimensional (3D) kinematical analysis, we characterized the movement of pea plants (Pisum sativum L.) towards a support with different thicknesses above and belowground (i.e., thin below, thick aboveground, or the opposite). As a control condition, the plants were presented to supports with the same thickness below- and aboveground (i.e., either entirely thin or thick). The results suggest an integration between the information from below- and aboveground for driving the reach-to-grasp behavior of the aerial plant organs. Information about the support conveyed by the root system seems particularly important to fulfil the end-goal of the movement.
Fundamental Clock of Biological Aging:
Convergence of Molecular, Neurodegenerative, Cognitive, and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology
Authors: Dyakin Victor Vasilyevich , Dyakina-Fagnano Nika Victorovna , McIntire Laura Beth , Uversky Vladimir Nikolaevich
Published: November 2021

In humans, age-associated degrading changes are observed in molecular and cellular processes underly the time-dependent decline in spatial navigation, time perception, cognitive and psy-chological abilities, and memory. Cross talk of biological, cognitive, and psychological clocks provides an integrative contribution to healthy and advanced aging. At the molecular level, ge-nome, proteome, and lipidome instability are widely recognized as the primary causal factors in aging. We narrow attention to the roles of protein aging linked to prevalent amino acids chirali-ty, enzymatic and spontaneous (non-enzymatic) post-translational modifications (PTMs SP), and non-equilibrium phase transitions. The homochirality of protein synthesis, resulting in the steady-state non-equilibrium condition of protein structure, makes them prone to multiple types of enzymatic and spontaneous PTMs, including racemization and isomerization. Spontaneous racemization leads to the loss of the balanced prevalent chirality. Advanced biological aging re-lated to irreversible PTMs SP has been associated with the nontrivial interplay between poor so-matic and mental health conditions. Through stress response systems (SRS), the environmental and psychological stressors contribute to the age-associated “collapse” of protein homochirality. The role of prevalent protein chirality and entropy of protein folding in biological aging is mainly overlooked. In a more generalized context, the time-dependent shift from enzymatic to the non-enzymatic transformation of biochirality might represent an important and yet un-der-appreciated hallmark of aging.
EL EXILIO EN MÉXICO: UN VACÍO JURÍDICO
Authors: Pérez Bravo Mauro
Published: November 2021

México ha implementado acciones legislativas con el objetivo de atender diferentes facetas de la movilidad humana (migración, desplazamiento forzado), sin embargo, consideramos que el exilio, como una faceta más, no se encuentra tan visibilizado o atendido en legislaciones sobre derechos humanos. Ya sea por las reducidas bases de datos, estudios o testimonios, el exilio carece de un ordenamiento legal especial, incluso, no hemos terminado de conocerlo y entenderlo conceptualmente, lo que deviene en una confusión con otros términos como asilo, refugio o destierro. Por lo anterior, la pregunta que desarrollaremos a lo largo del presente ensayo es: ¿es necesaria una legislación especial para atender a las personas en situación de exilio en México? Con lo que podremos plantear el debate jurídico sobre el exilio en México con una metodología analítica sobre las leyes e información disponible, además de una metodología comparada auxiliándonos de legislaciones internacionales. De esta manera, propondremos algunas bases para el desarrollo de una propuesta legislativa sobre el exilio en México.
DE LA INTERPRETACIÓN DEL ARTÍCULO 1728-BIS DEL CÓDIGO CIVIL DEL ESTADO DE CHIHUAHUA
Authors: Romero Ramos Eduardo
Published: November 2021

Este trabajo examina el alcance de la reforma legislativa que se introdujo al Código Civil del Estado de Chihuahua, en el Decreto publicado en el Periódico Oficial del Estado en fecha 8 de julio de 2020 que expide la Ley de Firma Electrónica del Estado, incluyendo además un artículo 1728 Bis al apartado de Formas del Consentimiento de los Contratos dentro del Título Primero, Capítulo I del Libro Cuarto del Código mencionado. La reforma tiene por propósito regular los avances tecnológicos del mundo actual y considerar la pertinencia de ampliar las formas que puede revestir el consentimiento, reconociendo la forma electrónica como medio formal de las voluntades que lo integran y como un elemento de validez de los contratos civiles que se celebran por medios electrónicos, ópticos o cualquier otra tecnología, bajo la condición de que la información generada por tales medios sea atribuible a las partes, pueda ser resguardada íntegramente y consultable con posterioridad
Cross-Cultural Adaptation, Validity and Reliability of the Igbo Version of the Brief Fear of Movement Scale for Osteoarthritis
Authors: Ekediegwu Ezinne , Anthonia Ezugwu Uchechukwu , Ikenna Uchenwoke Chigozie , Chidinma Tabansi-Ochiogu , Obidike Esther
Published: November 2021

Background; the brief fear of movement scale for knee osteoarthritis (b-FMSKOA) is a valid instrument for assessing fear of movement in individuals with OA. The objective of this study was to translate and culturally adapt the b-FMSKOA into Igbo language (b-FMSKO-I) and assess its validity and reliability in patients with knee osteoarthritis to promote its use in Igbo speaking parts of Nigeria.Methods; the original b-FMSKOA was translated and culturally adapted from English into Igbo following a standardized procedure according to Beaton et al., 2000 in seven separate processes of translation, back translation, committee review and pre-testing before being tested for psychometric quality. It was administered (within a 2day interval) to 15 consenting outpatients with knee OA who attended physiotherapy unit 3times a week in a selected South-eastern Nigerian hospital. The b-FMSKOA (English version) was correlated with the Igbo version. Results; the concurrent validity of the b-FMSKOA-I was found to be satisfactory and comparable to the original version. The correlation coefficient of the variables of interest were within the range of 0.441 and 0.998 and all showed significant correlation (p< 0.05) between the scores obtained from the English and Igbo version of the questionnaire except for the fourth item (r= 0.441; p=0.131) which showed no significant relationship. Cronbach’s alpha showed the questionnaire to reach acceptable reliability α = 0.85. The Pearson correlation coefficient of the variables of interest was within the range of 0.441 and 0.945 with the fourth and first item recording the lowest (r=0.441) and highest (r=0.945) correlation coefficient respectively. All variables showed significant correlation (p< 0.05) between the scores obtained from Igbo version of the questionnaires except for the fourth item (r= 0.441; p=0.131) which showed no significant relationshipConclusion; the b-FMSKO-I like the original version is a reliable, consistent and valid instrument that can be considered for use in South-eastern Nigeria for evidence based quality healthcare promotion in patients with knee osteoarthritis.
Effect of unconventional by-product on growth performance, digestibility, carcass characteristics, blood profile and cecal microbial activity in New Zealand white rabbits
Authors: Mahmoud Yasmin M.M. , Kholif Abd El-Kader Mahmoud , Elsabagh Mabrouk
Published: November 2021

This study addressed the effect of unconventional by-products on growth performance, carcass characteristics, some blood parameters, and caecal activities in New Zealand White (NZW) rabbits. A total of 48 weaned NZW rabbits (748 ± 9.50 g BW, 6 weeks old), randomly assigned into three treatment groups (16 each, individually housed), were fed a basal diet containing BBP at 0.00 (Control), 1.00 (Broc1) or 3.00 (Broc2) % on a dry matter (DM) basis as feed additives, for 8 weeks. The Broc2 rabbits showed the highest (P < 0.05) body weight gain and feed intake followed by the Broc1 group compared to the control one. Feed conversion ratio and performance index did not differ (P > 0.05) among treatments. Nutrient digestibility was higher (P < 0.05) for Broc1 and Broc2 rabbits compared to the control. Both Broc1 and Broc2 rabbits showed higher (P < 0.05) empty edible carcass, giblets, dressing, head, liver, heart and kidney weights, but showed a lower non-edible carcass weight compared to the control. Blood proteins and liver function enzymes were increased (P < 0.05) whereas the glucose, total cholesterol, uric acid and creatinine were decreased (P < 0.05) in Broc1 and Broc2 rabbits compared to the control. The caecal concentration of total volatile fatty acids was increased (P < 0.05) but that of ammonia was decreased (P < 0.05) with Broc1 and Broc2 groups of rabbits compared to those of control. Thus, dietary supplementation of BBP at 3% of DM in rabbits’ diets could improve their growth performance, carcass traits, liver function and blood profile as well as the caecal fermentation parameters.
Notum Protects Against Myocardial Infarction-Induced Heart Dysfunction By Alleviating Cardiac Fibrosis
Authors: Su Wei , Fang Ruonan , Li Yue , Li Liangliang , Zhang Jing , Lv Xin , Yang Na , Wang Qianqian , Zhang Guofang , Li Xuelian , Shan Hongli , Li Tianyu
Published: November 2021

Cardiac fibrosis is a pathological reparative process that occurs subsequent to myocardial injury. It is associated with cardiac systolic and diastolic dysfunction and reduced cardiac compliance that eventually leads to heart failure. Delaying or inhibiting the progression of pathological myocardial fibrosis is of great significance for the treatment of many cardiovascular diseases. The Wnt signaling pathway is closely related to the occurrence of organ fibrosis, and Notum is a highly conserved secreted feedback inhibitor of Wnt signaling. It has been shown that Notum acts as a regulator in many organs, such as the aging intestinal epithelium, adult ventricular-subventricular zone neurogenesis, and mouse tooth root development. However, the role and mechanism of Notum on cardiac fibrosis are not well-understood. In this study, we found that Notum significantly increased survival rate and improved cardiac function following myocardial infarction in mice. More importantly, Notum inhibited the Wnt/β-catenin signaling pathway and senescence of cardiac fibroblasts, thereby decreasing the activation of cardiac fibroblasts, reducing the excessive deposition of extracellular matrix, and ultimately inhibiting the occurrence of cardiac fibrosis. Taken together, our findings demonstrated the anti-fibrotic effects of Notum on maladaptive cardiac fibrosis, and suggest that it may be a new strategy for the treatment of cardiac fibrosis.
Hadean/Eoarchean Tectonics and Mantle Mixing Induced by Impacts: a Three-dimensional Study
Authors: Borgeat Xavier , Tackley Paul
Published: November 2021

The timing of the onset of plate tectonics on Earth remains a topic of strong debate, as does the tectonic mode that preceded modern plate tectonics. Understanding possible tectonic modes and transitions between them is also important for other terrestrial planets such as Venus and rocky exoplanets. Recent two-dimensional modelling studies have demonstrated that impacts can initiate subduction during the early stages of terrestrial planet evolution - the Hadean and Eoarchean in Earth's case. Here, we perform three-dimensional simulations of the influence of ongoing multiple impacts on early Earth tectonics and its effect on the distribution of compositional heterogeneity in the mantle, including the distribution of impactor material. We compare two-dimensional and three-dimensional simulations to determine when geometry is important. Results show that impacts can induce subduction in both 2-D and 3-D and thus have a great influence on the tectonic regime. The effect is particularly strong in cases that otherwise display stagnant-lid tectonics: impacts can shift them to having a plate-like regime. In such cases, however, plate-like behaviour is temporary: as the impactor flux decreases the system returns to what it was without impacts. Impacts result in both greater production of oceanic crust and greater recycling of it, increasing the build-up of subducted crust above the core-mantle boundary and in the transition zone. Impactor material is mainly located in the upper mantle, at least at the end of the modelled 500 million year period. In 2-D simulations, in contrast to 3-D simulations, impacts are less frequent but each has a larger effect on surface mobility, making the simulations more stochastic. These stronger 2-D subduction events can mix both recycled basalt and impactor material into the lower mantle. These results thus demonstrate that impacts can make a first-order difference to the early tectonics and mantle mixing of Earth and other large terrestrial planets, and that three-dimensional simulations are important so that effects are not over- or under-predicted.
Metaplastic Breast Cancer: Mesenchymal Subtype Has Worse Survival Outcomes
Authors: Özkurt Enver , Emiroğlu Selman , Cabioğlu Neslihan , Karanlık Hasan , Önder Semen , Tükenmez Mustafa , İğci Abdullah , Özmen Vahit , Müslümanoğlu Mahmut
Published: November 2021

PurposeMetaplastic breast carcinoma (MBC) is a rare type of breast cancer that accounts for 0.2-1% of all breast cancers. To date, there are only few institutional studies comparing survival rates between different subtypes. In this retrospective cohort study, we aim to evaluate factors effecting survival rates of different subtypes of MBC.MethodsThis retrospective cohort study observed 118 non-metastatic MBC patients record extracted from 15,244 breast cancer cases between December 2000 and December 2020. In order to analyse factors effecting survival rates of mesenchymal subtype of MBC, all cases are classified as mesenchymal (n=45) and other (n=48). Twenty-five cases that could not be sub-classified due to the missing data. Univariate and multivariate logistic regression analysis were performed to define factors associated with survival rates.ResultsOf the 15,244 cases, 118 (0.8%) were non-metastatic MBC. 105 were triple negative and 12 were non-luminal HER2. There was no significant difference between mesenchymal and other subgroups for age, median tumour size, AJCC staging, and type of surgery. Of the five local recurrences with known subgroup, four of them had mesenchymal subtype. It is demonstrated that mesenchymal subtype was significantly associated with worse 5-year disease-free survival and disease specific survival (HR: 2.35 [1.01-5.48], p=0.049 and HR: 3.16 [1.06-9.47], p=0.040 with 95% CI respectively).ConclusionThis study is one of the few studies presenting the survival outcomes of subtypes of MBCs. Nonetheless, it is the only study demonstrating that mesenchymal subtype had worse survival outcomes. Further studies are needed to determine the outcome of different subtypes of MBCs.
The Meta-Analysis About The Expression and Prognosis of Anti-Ro-52, Anti-CENP-B and AMA in Sjogren's Syndrome and Systemic Sclerosis
Authors: Shao Xinyang , Qiu Yanbing , Yang Yuqin , Zhu Yan , Zhang Wenling
Published: November 2021

Objective This project aims to investigate the diagnostic value of anti-Ro-52, anti-CENP-B, and AMA in Sjogren's syndrome and systemic sclerosis. Methods We constructed the Meta-analysis to evaluate the existing experimental data and obtain the advantages of the three antinuclear antibodies compared with traditional test items using specific data processing methods and evaluated their value in the diagnosis as well as the differential diagnosis of Sjogren's syndrome and systemic sclerosis. During the process of paper collection, we strictly followed the principle of PICOS to screen the literature, trying to include the literature with a large sample size, controversial and influential results which would make the results of this Meta-analysis more valuable. In this study, Revman and Stata software was used for data processing, and the forest map was drawn to analyze the difference in antibody-positive rate, age, and gender distribution, and other factors. At the same time, a funnel plot was used to evaluate the bias of literature results.Results The positive rate of anti-Ro-52 in SS and SSC was higher than that of anti-SSB (P < 0.00001); The positive rate of anti-CENP-B in SSc patients was higher than that in anti-SSB patients (P < 0.00001), but there was no significant difference in SS patients (P = 0.77); The positive rate of AMA in SS and SSc was significantly lower than that in ANA (P < 0.00001), but the expression of AMA increased in SS patients with autoimmune hepatitis. In patients with anti-Ro-52 positive SS and SSc associated with EBV infection, the former had a significantly increased risk of developing malignant lymphoma, while the latter had more severe symptoms of tissue fibrosis. Conclusion The accuracy of anti-Ro-52 in the diagnosis of SS and SSC is higher. The positive rate of anti-CENP-B in the diagnosis of SSc is higher than that of anti-SSB and anti-Scl-70. SS patients with EBV infection are more likely to develop into malignant lymphoma, while SSc patients with EBV infection have increased skin fibrosis and inflammation.
Predictors of early initiation of breast feeding; Evidence from 2019 Ethiopian mini demographic and health survey
Authors: lucha Tadele Abate , Mengistu Admassu Ketsela
Published: November 2021

Background: World health organization (WHO) recommended all mothers should be supported to initiate breastfeeding as soon as possible after birth within the first hour. This study examined the determinants of early initiation of breastfeeding in Ethiopia by using data from 2019 Ethiopia mini demographic and health survey (EMDHS)..Methods: The data for this study was extracted from 2019 EMDHS. A total of 3752 children born during the last 24 months at the time of survey were included for analysis from the nine regional states and two city administrations. Descriptive statistics was used to identify the proportion of children who had early initiation of breastfeeding (EIBF) after which multivariable logistic regression analysis was carried out to determine the predictors of EIBF. Results were presented using frequencies, percentages, p-value, crude and adjusted odds ratios. Statistical significance was declared at p <0.05 for the multivariable logistic regression analysis .Result: The prevalence of Early Initiation of Breastfeeding (EIBF) in Ethiopia was remarked to be 73.7% (n = 2767). Place of delivery [AOR =1.65, 95% CI: 1.39, 1.96] mother who deliveries at health facility had higher odds to practice early breast-feeding than those who deliveries at home, mode of delivery [ AOR = 3.94, 95% CI: 2.99, 5.17] mother who had deliveries by vaginal had 3.9 times higher odds to practice early breast-feeding compared with cesarian section and parity [ AOR = 1.57, 95% CI: 1.23, 2.00] mother who had more than five children had higher odds to practice early breastfeeding compared with first time babies. In addition, early breast-feeding initiation was also associated with region where mothers residing particularly in regions such as Oromia [AOR = 1.78, 95% CI: 1.26, 2.53] had higher odds to practice early breast feeding as compared with mothers residing in Tigray.Conclusions: The overall prevalence of EIBF was determined to be 73.7%. EIBF in Ethiopia was found to be significantly associated with place of delivery, mode of delivery, parity and region. Focus should be given to expand institutional delivery and increase awareness of mothers with their first delivery .
Biocontrol Potential of The Phloridin-Degrading Bacillus Licheniformis XNRB-3 Against Apple Replant Disease
Authors: Yanan Duan , Lei Zhao , Weitao Jiang , Ran Chen , Rong Zhang , Xuesen Chen , Chengmiao Yin , Zhiquan Mao
Published: November 2021

Background: Apple replant disease (ARD) is a common occurrence in many major apple-growing areas worldwide, seriously hindering the development of the apple industry. To avoid the shortcomings of chemical fungicides currently used to control ARD, it is necessary to find sustainable and effective control methods. Here, an endophytic phloridin-degrading Bacillus licheniformis XNRB-3 was isolated from the root tissue of healthy apple trees, and its control effect on apple replant disease (ARD) and its how to alleviates the pathogen pressure via changes in soil microbiomes were studied.Results: The addition of strain XNRB-3 in Fusarium infested soils significantly reduced the number of pathogens in the soil, thus resulting in a lower disease incidence, and the relative control effect reached more than 60%. The fermentation broth can also protect the roots of the plants from Fusarium infection. These antagonistic effects were further validated using an in vitro assay in which the pathogen control was related to growth and spore germination inhibition via directly secreted antimicrobial substances and and indirect interspecific competition for nutrients. The antifungal organic compounds in the fermentation metabolites were identified using GC-MS technology. Among them, alpha-bisabolol and 2,4-di-tert-butylphenol had significant inhibitory effects on many planted pathogenic fungi. Butanedioic acid, monomethyl ester, and dibutyl phthalate can promote the root elongation and lateral root development of Arabidopsis plants. The potential of strain XNRB-3 to control ARD was later validated using microbial fertilizer inoculation in pot and field experiment. The addition of strain XNRB-3 significantly promoted the growth of plants, and the activity of enzymes related to disease resistance (SOD, POD, and CAT) was also significantly enhanced. It also reduced the abundance of Fusarium and the content of phenolic acids in the rhizosphere soil, improved soil microbial community structure and nutritional conditions, and increased soil microbial diversity and activity, as well as soil enzyme activity. Conclusions: The incorporation of strain XNRB-3 in the soil alleviated the damage of soil-borne pathogens to plants by reducing the relative abundance of pathogenic fungi and the content of phenolic acids, and inducing disease resistance of plants. Taken together, B. licheniformis XNRB-3 could be developed into a promising biocontrol and plant-growth-promoting agent. This provides a new management strategy to control ARD.
Outcomes and Resource Utilization in Calcium Pyrophosphate Deposition Disease Patients Who Underwent Total Knee Arthroplasty: A Retrospective Cohort Analysis.
Authors: Parperis Konstantinos , Hadi Mohanad , Bhattarai Bikash
Published: November 2021

Background: To evaluate the predictors, outcomes and resource utilization of total knee arthroplasty (TKA) in calcium pyrophosphate deposition disease (CPPD) patients. Methods: We used the US National Inpatient Sample database to identify CPPD and non-CPPD who underwent TKA from 2006 to 2014. Data collection included patient demographics and comorbidities. Outcomes following TKA included in-hospital mortality, complications, length of hospitalization, hospital charges, and disposition.Results: Among the 5,564,005 patients who have undergone TKA, 11529 (0.20%) had CPPD, with a median age of 72 years and 53.7% were females. Compared with non-CPPD, patients with CPPD were more likely to be older (mean: 72 vs 66 years; p<0.001), male, white, and have Medicare insurance. CPPD patients were more likely to have ≥ 2 comorbidities calculated by the Charlson comorbidity index and discharge to an inpatient/rehabilitation facility. Regarding inpatient complications, myocardial infarction and knee reoperation were significantly more common in CPPD patients. TKA in CPPD patients was associated with significantly higher odds of increased length of stay (>3 days) than those without CPPD (OR 1.43, 95% CI 1.37-1.49). There was no significant difference in the in-hospital mortality.Conclusions: CPPD patients who underwent TKA were more likely to have a longer hospital stay and discharge to a non-home setting than non-CPPD. Also, CPPD patients had a higher comorbidity burden, and greater risk for myocardial infarction and need for reoperation.
PGK1 Promotes NSCLC Progression by Enhancing Aerobic Glycolysis and Activating AKT/ERK Signaling Pathway
Authors: Tang Yongqin , Li Mei , Hei Jinxuan , Ma Likun , Pan Jianyuan
Published: November 2021

Metabolic reprogramming, especially aerobic glycolysis is considered a hallmark of cancer, and is becoming a novel target for cancer therapy. Phosphoglycerate kinase I (PGK1) which is an important enzyme generating the first ATP in glycolysis pathway was already shown can promote some types of cancer development and progression, however, the role of PGK1 in lung cancer development is less reported. The aim of this study was to explore the mechanism of PGK1 in promoting non-small cell lung cancer (NSCLC) development and progression. Gene overexpression or silencing, scratch assay, Trans-well assay, western blot, immunohistochemistry, chromatin immunoprecipitation, real-time quantitative RT-PCR, MTT cell viability assay and mouse xenograft, glucose uptake, lactate secretion, ATP production and Extracellular Acidification Rate (ECAR) seahorse assay were performed to investigate the biological function and the underlying mechanism of PGK1 in NSCLC development. Our study found that PGK1 was high expressed in non-small cell lung cancer tissues, its expression is positive correlated with tumor grade and clinical stage and negative correlated with patients’ overall survival. Importantly, its expression was also associated with clinicopathological characteristics of lung cancer patients. Overexpression PGK1 could not only promote lung epithelial cell and tumor cell migration and proliferation in vitro, but also increase the tumor growth in vivo. Mechanically, PGK1 promotes NSCLC development and progression by activating AKT/ERK signaling pathway and altering aerobic glycolysis pathway. Meanwhile PGK1 was HIF1α downstream target gene and played an essential role in hypoxia-induced shift of glycolysis. In addition, the PGK1 expression was positive correlated with HIF1α expression in NSCLC tissues. Therefore, we concluded that PGK1 could be a biomarker for NSCLC diagnosis and outcome evaluation, and targeting PGK1 should be an innovative strategy for NSCLC therapy in the future.
Supportive effect of naringenin on NaCl-induced toxicity in Carthamus tinctorius seedlings
Authors: Hatamipoor Shahab , Shabani Leila , Farhadian Sadegh
Published: November 2021

Background

The exogenous application of priming molecules to plants helps them to develop tolerance against salinity stress. In the present study, we used exogenous naringenin (0.5 mM) pretreatment before the stress in safflower seedlings under 25 mM NaCl to elucidate the role of naringenin to alleviate oxidative conditions associated with salinity complications.
Results

Our results showed biomass, leaf relative water content, chlorophyll content, K+ content, and K+/Na+ ratio were negatively affected by 25 mM NaCl. However, the H2O2 accumulation, malondialdehyde (MDA) content, antioxidant enzymes and Na+ content of NaCl-stressed safflower seedlings were remarkably increased. The results obtained in the present study showed the beneficial effects of the pre-treatment of naringenin in safflower seedlings under non-salinity stress condition with respect to increasing plant biomass, total phenolic compound, radical scavenging activity (RSA), soluble sugar content, proline, glutathione, enzymatic antioxidants, and K+ content. Also, the results showed that naringenin pre-treatment can (partly) be overcome NaCl-induced stress on safflower seedlings, probably due to higher accumulation of plant biomass, total phenolic compound, RSA, catalase (CAT) activity, and K+/Na+ ratio as well as lowering the H2O2 and MDA content in the leaves.
Conclusions

Generally, it could be concluded that, pre-treatment of naringenin before stress could partly diminish NaCl-caused oxidative stress in safflower seedlings, probably due to improvement in enzymatic and non-enzymatic antioxidant and reduced cell membrane damage.
Plant Growth and LAI Estimation using quantized Embedded Regression models for high throughput phenotyping
Authors: Sheth Dhruv
Published: November 2021

Due to the influence of climate change, and due to it's unpredictable nature, majority of agricultural crops have been affected in terms of production and maintenance. Hybrid and cost-effective crops are making their way into the market, but monitoring factors which affect the increase in yield of these crops, and conditions favorable for growth have to be manually monitored and structured to yield high throughput. Farmers are showing transition from traditional means to hydroponic systems for growing annual and perennial crops. These crop arrays possess growth patterns which depend on environmental growth conditions in the hydroponic units. Semi-autonomous systems which monitor these growth may prove to be beneficial, reduce costs and maintenance efforts, and also predict future yield beforehand to get an idea on how the crop would perform. These systems are also effective in understanding crop drools and wilt/diseases from visual systems and traits of plants.Forecasting or predicting the crop yield well ahead of its harvest time would assist the strategists and farmers for taking suitable measures for selling and storage. Accurate prediction of crop development stages plays an important role in crop production management. In this article, I~propose an Embedded Machine Learning approach to predicting crop yield and biomass estimation of crops using an Image based Regression approach using EdgeImpulse that runs on Edge system, Sony Spresense, in real time. This utilizes few of the 6 Cortex M4F cores provided in the Sony Spresense board for Image processing, inferencing and predicting a regression output in real time. This system uses Image processing to analyze the plant in a semi-autonomous environment and predict the numerical serial of the biomass allocated to the plant growth. This numerical serial contains a threshold of biomass which is then predicted for the plant. The biomass output is then also processed through a linear regression model to analyze efficacy and compared with the ground truth to identify pattern of growth. The image Regression and linear regression model contribute to an algorithm which is finally used to test and predict biomass for each plant semi-autonomously.
Posterior integration and thalamo-frontotemporal broadcasting are impaired in disorders of consciousness
Authors: Panda Rajanikant , López-González Ane , Gilson Matthieu , Gosseries Olivia , Thibaut Aurore , Frasso Gianluca , Cecconi Benedetta , Escrichs Anira , Collaborators GIGA group , Deco Gustavo , Laureys Steven , Zamora-López Gorka , Annen Jitka
Published: November 2021

The study of the brain’s dynamical activity is opening a valuable source of assistance for the clinical diagnosis of patients with disorders of consciousness (DOC). For example, dysfunctional spread of naturalistic and synthetic stimuli has proven useful to characterize hampered consciousness. However, understanding of the mechanisms behind loss of consciousness following brain injury is still missing. Here, we study the propagation of endogenous and in-silico exogenous perturbations in patients with DOC, based upon directed and causal interactions estimated from resting-state fMRI. We found that patients with DOC suffer decreased capacity for neural propagation and responsiveness to events. Particularly, that loss of consciousness is related to the malfunctioning of two neural circuits: the posterior cortical regions failing to convey information, in conjunction with reduced broadcasting of information from subcortical, temporal, parietal and frontal regions. These results seed light on the mechanisms behind DOC, thus opening new possibilities for clinical applications.