bluuebunny/crossref_metadata_2025 huggingface dataset:
A Secure Medical Image Transmission System Based On 2D Logistic Map and Diffie-Hellman Key Exchange Mechanisms
Authors: Wady Shakhawan H. , Yousif Raghad Z.
Published: November 2022

With the tremendous growth of searchable visual media, the content-based medical image retrieval and computer-aided diagnosis systems have become popular in recent years to improve knowledge and provide facilities for radiologists. Medical images transferred throughout public networks demand a mechanism that guarantees image privacy, ownership and source of origin reliability, and image integrity verification. For this reason, secure image retrieval and diagnosis scheme have been given considerable interest due to users’ security concerns. This work proposed a secure framework based on a two-dimensional (2D) chaotic map with Diffie–Hellman key exchange protocols to ensure patient information privacy and security. Consequently, from a security and protection perspective, the objective is to provide a privacy procedure for medical image retrieval systems through image encryption technique combined with a secure key exchange procedure to minimize the possibility of secret key interception by an unauthorized person. Simulation results and security analysis show that the suggested technique could protect images with minimal time complexity and a high level of security while also resisting numerous attacks.
Literature Visualization Analysis of Ideological and Political Education in Universities - Based on CSSCI Database from 2012 to 2022
Authors: Gao Na
Published: November 2022

This study is mainly based on the academic journals included in CNKI that set the theme as the source of journals that restrict the ideological and political education in colleges and universities as the research object. The annual number of publications, the author’s situation, the source of journals, the co-word and dissimilarity matrix drawn according to the frequency of keywords and the social network map are visually analyzed, highlighting the current hot topics in the research of ideological and political education in colleges and universities in China, and predicting the future research trend. Finally, the development of ideological and political education in colleges and universities is considered and reasonable suggestions are put forward to provide a basis for further research on ideological and political education in colleges and universities.
Historical Comparison of Eastern and Western Ideas of Struggle
Authors: Wang Tingyu
Published: November 2022

In both Eastern and Western cultures, the word struggle has a profound historical connotation, and along with historical changes and continuous cultural integration, the idea of struggle has gradually taken on Chinese and Western cultural connotations and values. Eastern struggle is derived from pictograms, which means to struggle with vigor, while the Western struggle is derived from the etymology of struggle, which emphasizes individual struggle. After tracing the connotation of both cultures, we find that the struggle in both cultures has a common pursuit, that is, the struggle for the realization of the ideal personality and the common pursuit of virtue and value, while the differences are expressed in the respective tendencies of rational appearance and practical practice, as well as the division of discourse between individualism and collectivism.
Investigation on Social Anxiety of Secondary Vocational Students
Authors: Liao Chao , Xu Jie , Chen Gang , Zhang Zhongqin , Zhang Wei , Pi Liuli , Yu Bo , Luo Jun
Published: November 2022

Objective: To investigate the status quo of social anxiety among secondary vocational students and the differences in demographic variables through the Communication Anxiety Scale (IAS) survey. Methods: A total of 890 students from a secondary vocational school in Changshou District of Chongqing were surveyed with the Communication Anxiety Scale (IAS) to understand the social anxiety of secondary vocational students. Results: The mean score of social anxiety of secondary vocational students was 45.25±9.32. The gender difference of social anxiety in secondary vocational students was significant (P<0.001). There was no significant difference in social anxiety of secondary vocational students in grade (P>0.05); The social anxiety of secondary vocational students was significantly different in household registration type (P<0.001); There was no significant difference in social anxiety between only children and non-only children (P>0.05). The difference of social anxiety in family income of secondary vocational students was very significant (P<0.001). Conclusion: The level of social anxiety of secondary vocational students is above the middle level. From the perspective of gender variables, there is a significant difference in the level of social anxiety between male and female students, and the level of social anxiety of male students is significantly lower than that of female students. In terms of grade variables, there was no significant difference in social anxiety in grade variables. From the perspective of the variable of residence type, social anxiety is significantly different between rural students and urban students. The level of social anxiety of rural students is higher than that of urban students. There is no significant difference between only-child and non-only-child in social anxiety. From the perspective of family income level, social anxiety is significantly different among different income families. Students from families with wages higher than the average social level had the lowest level of social anxiety, students from families with wages comparable to the average social level had higher levels of social anxiety, and students from families with wages lower than the average social level had the highest level of social anxiety.
A Comparative Study of Active Solo and Dual Inclined Compound Parabolic Concentrator Collector Solar Stills Based on Exergoeconomic and Enviroeconomic
Authors: Bansal Sarthak , Singh Dharamveer
Published: November 2022

Abstract: The Parabolic Concentrator (CPC) is a uniform photovoltaic thermal (PVT) compound linked to solar photos (N) of water collectors called PVT-CPC Active Solar Filtration System Analysis. New Delhi Analysis is done for a solar filter system for a given particle size under weather conditions. We assess efficiency, system productivity, and life cycle cost analysis. The Thermal Model Life cycle cost efficiency (LCCE), designed for LCCE analysis, is considered the only and double-doubled effective PVT-CPC system for filtering solar energy recovery time. In this work, we need to analyze the appropriate points of the collector and extract the bulk of the system. Tests were performed on dual-solar and dual-inclined PVT-CPC operating systems with a single basin size and a water depth of 0.14 m, with yield on yearly basis, factor of energy payback, and efficiency of life cycle cost conversion analysis of 5.0%, 12.63%. Moreover, 22.21% is two times higher than the solo inclined system. In addition, the water return, one PVT-CPC, and two turns have been found to have a recovery time (EPT) with an interest rate of 5%. The solar filter system is 10.89% and 17.99% higher than the solo inclined photovoltaic thermal compound parabolic concentrator activated solar filter system, respectively. The above analysis concluded, we can confirm that the two bends are better than the active PVT-CPC system for solar filtering, which is the only inclination of the depth of 0.14 m in water based on daily based analysis. If depth of water 0.14 m is more significant, for basin size provided the performance of one inline is improved and is better than curved solar-powered filtering systems. The upgraded system lasts longer and can meet potable water and DC electricity on sunny commercial days.
Hand Gesture based Speech Recognition system for Hard of Hearing People
Authors: Tippannavar Sanjay S , M S Surya , Yadav Pilimgole Sudarshan , Salman Mohammed Zaid , M Ajay
Published: November 2022

Abstract: For people who are intellectually challenged, this document provides a sign to speech translator. In contemporary society, the dumb have very little ability to converse with the normal person. Therefore, they are unable to interact with common people until common people, like ourselves, learn how to communicate through sign language. Dumb sign language is not something that everyone can learn because it is so challenging to perfect. Because of this, nobody can go and talk to these physically challenged persons. So, here is a system that would make it possible for those who are illiterate to speak with everyone. With today's technology, even the deaf may communicate by making hand gestures. Each hand gesture is set to play back a different audio message. Hand motions were captured by a flex sensor and an accelerometer, and the microcontroller then accepted these inputs. The flex sensor tracks hand movements and detects deflections, converting them into the right signals that trigger the system to produce recorded sound signals for transmission via the speakers. There are many different Arduino Boards available right now, and they can be used for a variety of things. The Arduino Mega 2560 is the ideal solution since it is the most cost-effective, allows faster computing, and can integrate and interface various sensors while consuming less power. The device under discussion is basically made up of a glove and a microcontroller-based system. Four strategically placed flex sensors are included in the data glove.
DigiBasket: The Grocery Store Web App
Authors: Sarkar Koyel , Khatri Harsh , Shrivastav Jayant , Singh Manvendra
Published: November 2022

Abstract: Online Grocery Store is an eCommerce based web application for our Web Programming project. We had developed a sample in which user can search and find necessary information about any grocery item, can proceed to checkout to buy products. User can create an account, update personal information, can check its past activities, orders and transaction. A grocery store (AE), grocery shop (BE) or simply grocery is a store that primarily retails a general range of food products, which may be fresh or packaged. In everyday U.S. usage, however, "grocery store" is a synonym for supermarket, and is not used to refer to other types of stores that sell groceries. In the UK, shops that sell food are distinguished as grocers or grocery shops (though in everyday use, people usually use either the term "supermarket" or a "corner shop" or "convenience shop"). Larger types of stores that sell groceries, such as supermarkets and hypermarkets, usually stock significant amounts of non-food products, such as clothing and household items. Small grocery stores that sell mainly fruit and vegetables are known as greengrocers (Britain) or produce markets (U.S.), and small grocery stores that predominantly sell prepared food, such as candy and snacks, are known as convenience shops or delicatessens.
A Survey on Smart Security Applications for Safety
Authors: Viswase Aayush , Shelar Akanksha , Mirje Ekant , Kumar Anupam , Shelke S M
Published: November 2022

Abstract: Women’s safety is very important and it is a major concern nowadays, Building an efficient, quick, and trustworthy method to provide women with a sense of empowerment and safety is the project’s major goal. The app we developed will serve as a very helpful companion for women, ensuring that they'll never feel that they are in the middle of a crisis or difficult situation alone. This android application is a very user-friendly application that can be used by anyone who has installed the application on their respective smartphones. It is an android app for women's safety, yet it can also be used by men in emergencies. You can use the SOS key or a voice command to activate it. On activation, it sends a message comprising this location URL to the registered contacts and also calls on the first registered contact to help the one in dangerous situations. Due to a lack of sufficient evidence, many instances remain unsolved. In order to preserve evidence, we have preserved the audio recording option. Some of this system's most helpful features are offline mode, safe zone visualization, and continuous position tracking.
Power Minimization by Designing Novel Architecture for Multimodal Biometric System
Authors: M. G. Mrs. Manasa , S Dr. Gayathri
Published: November 2022

Abstract: The reduction of power, area, and delay parameters are increasing as the range of sophistication of applications in VLSI circuit designs. Adders and multipliers play a vital role in VLSI circuit designs to minimize the power consumed by the circuit. The Finite Impulse Response Filter is widely used in Digital Signal Processing Applications, such as speech processing, loudspeaker equalization, echo cancellation, noise cancellation, arithmetic computations and, image-processing applications. In FIR filter, the adders and multipliers are the important components to reduce the power, delay and area. Therefore, this proposed method faced with more constraints: as minimal power as possible. This work proposes a design of low power Finite Impulse Response Filter using Carry Skip Adder.The recent electronics industry uses digital filters for various real time applications. A novel VLSI architecture is designed by using ALU based FIR filters for biometric system. Where in ALU includes adders and multipliers, comparing different adders for there better performance with respect to power and identifying carry skip adder will consume less power compared to other adders. power consumption of overall architecture by including carry skip adder is very less and we can use this same adder for multimodal architecture also.
Theoretical Approach to Investigate Temperature Dependent Ultrasonic and Thermophysical Properties of Ti-Zr-Hf Ternary Alloy
Authors: Singh Ramanshu P. , Yadav Shakti , Singh Devraj , Mishra Giridhar
Published: November 2022

Abstract: In this study, we have computed temperature dependent ultrasonic and thermophysical properties of hcp medium entropy alloy Ti-Zr-Hf in temperature range of 0K-900K. Second order and third order elastic constants (SOECs and TOECs) have been calculated using lattice parameters using the Lennard-Jones potential model. With the help of SOECs and TOECs, the elastic parameters such as bulk modulus, shear modulus, Young’s modulus, Poisson’s ratio have been computed. SOECs were also utilized to determine the ultrasonic velocities at different angle along unique axis. Further, thermophysical properties such as Debye temperature, Debye heat capacity, energy density in temperature range of 0K-900K and thermal conductivity in temperature range of 300K-900K have also been theoretically estimated. Additionally, the ultrasonic attenuation due to phononphonon interaction in both longitudinal and shear mode and thermoelastic mechanism have been computed for chosen alloy in the temperature range 300K-900K and attenuation due to the phonon-phonon interaction was found to be dominating over that due to thermoelastic mechanism
Assessment of Intermediate Public Transport as A Feeder System to Metro: A Case of Thane City
Authors: Chandrashekhar Gatne Deepamkar , Nikam Madhuri
Published: November 2022

Abstract: Metro System is been built to provide the service to its people and scale up the facility provided, this would also require the response of people and shift from their mode of transportation. With heavy transportation and day-to-day increase in the traffic on road there is a need to use the Public Transportation. The Detailed Project Report (DPR) for Thane Metro was made in the year 2017, but there is no feeder plan yet, this gives an opportunity to study this respective field. This dissertation aims at getting to know the responses of the commuters of the metro and also of the operators in the catchment area thus providing an efficient last mile connectivity with the Intermediate Public Transport modes available thereof, the catchment area has been selected in accordance with the Metro Policy, 2019. Road Inventory survey of the area gives a detail information about the physical condition present and help to decide the feeder route. In conclusion, this dissertation will provide a convenient way so as to improve the ridership of metro
Solution for Reduction of Traffic Congestion: A Case Study of Intersection on Badlapur- Katai Road
Authors: Konge Pratik Diliprao , Nikam Madhuri
Published: November 2022

Abstract: The increasing vehicular traffic on roads is growing issue in today’s life. This leads to the congestion on the streets and degrades safe and efficient movement of traffic. This is becoming an important issue in the urban premises. It is observed that traffic congestions take place majorly at the intersections where the entering and exiting traffic from the towns to the highways creates conflicts due to improper movement. This study intended to examine flow of traffic at an intersection on Badlapur – Katai road in state of Maharashtra. The location is a part suburban areas of Mumbai metropolitan city. The Majority population is of working class also the industrial development in this area is high due to MIDC and thus the road carries huge traffic during peak hours. The study comprises of collection of the current traffic volume data, projection of the traffic for next 20 years and analysing the intersection for its serviceability. The outcomes may show the requirement of improvement of intersection as grade separated intersection.
Juxtaposition of Push-Type Wheel Hoe to Evaluate Its Weeding Coherence and Impair on Eggplant
Authors: Shekhar Gargi , Srivastava Anshuka , Narang Happy
Published: November 2022

Abstract: A study was done to access the best suited mechanical weed control method in eggplant crop as use of mechanical methods in eggplant crop will enhance the crop growth and reduce the use of herbicides and chemicals that affect the soil properties of crop. The weeding efficiency of the wheel hoe1 and wheel hoe2 was calculated at different levels of forward speed and depth of weeding in Allahabad region in eggplant crop at 21st, 40th and 75th day after sowing. The plant damage was recorded at the fifth day after the weeding operation was performed in the field. The plant damage increased as the speed of operation increased but the depth of operation had no significant effect on the plant damage. Plant damage was dependent upon the skill of the operator and environmental factors like sunshine, wind etc
Protection of Children Involved in Online Prostitution Cases in Terms of Law of Children Protection
Authors: Meiliana Nurcahyani  , Anang Dony Irawan
Published: November 2022

Abstract
The purpose of this paper was  to analyze the extent to which the law provides for legal protection for children involved in online prostitution  by using the media of chat applications.  The research method used is a normative legal research method with a statutory approach.  The results showed that for child offenders, provisions in Law No. 11/2012 concerning the Juvenile Criminal Justice System apply. Meanwhile, criminal acts that ensnare perpetrators such as pimps and also service users must also be subject to pidana in accordance with Law Number 17 of 2016 which stipulates the threat of punishment more severe than the Criminal Code.  The participation of the community, relevant institutions and also the government must be more active in following up on this case of online prostitution, the government must strictly revoke applications circulating in the virtual world and set penalties for perpetrators involved in this criminal act.
Abstrak
Tujuan dari penulisan ini menganalisis sejauh mana undang-undang mengatur tentang perlindungan hukum bagi anak yang terlibat dalam prostitusi online dengan mengunakan media aplikasi chatting. Metode penelitian yang digunakan adalah metode penelitian hukum normative dengan pendekatan peraturan perundang-undangan. Hasil penelitian menunjukan bahwa untuk pelaku anak, berlaku ketentuan di UU No. 11/2012 tentang Sistem Peradilan Pidana Anak. Sedangkan tindak pidana yang menjerat pelaku seperti mucikari dan juga pengguna jasa juga harus dikenakan pidana sesuai dengan Undang-Undang Nomor 17 tahun 2016 yang menetapkan ancaman hukuman lebih berat dibanding Kitab Undang-undang Hukum Pidana. Peran serta masyarakat, lembaga-lembaga terkait dan juga pemerintah haruslah lebih aktif dalam menindaklanjuti kasus ini prostitusi online, pemerintah harus tegas mencabut aplikasi yang beredar didunia maya dan menetapkan hukuman bagi para pelaku yang terlibat dalam tindak pidana ini.
Pelaksanaan Eksekusi Hak Asuh Anak Dalam Perkara Perceraian (Studi Kasus Putusan No 1618/Pdt.G/2020/PA.Smp)
Authors: Sari Laily Lukita Nilam , Suprayitno Wasis , Kurniawan Kukuh Dwi
Published: November 2022

Article 1 of Law no. 1 of 1974 states that "marriage is physically and mentally between a man and a woman as husband and wife to form a happy family and based on the Almighty God". However, many problems in the household result in divorce, which causes various problems. One of the problems that occur as a result of divorce is child custody. One example is case decision number 1618/Pdt.G/2020/PA.Smp. This study aims to determine the basic considerations related to child custody following case decision number 1618/Pdt.G/2020/PA.Smp. In addition, it also aims to determine the obstacles in executing child care (Hadhanah) in the decision of the Sumenep Religious Court Number 1618/Pdt.G/2020/PA.Smp. This research is sociological juridical research using a statute approach and a case approach. Results Based on research and discussion, it is known that the Panel of Judges, in deciding this case, used Article 105 of the Compilation of Islamic Law, namely regarding the maintenance of children who are still not mumayyiz and also used the basis of legal considerations that are theoretically appropriate in terms of the principles that are the main reference in providing in the decision, the rules of Islamic law, as well as the provisions of the applicable laws and regulations.
COMPARATIVE EFFICACY OF DICLOFENAC SODIUM VERSUS COMBINATION OF PARACETAMOL AND IBUPROFEN FOR ACUTE POSTOPERATIVE TONSILLECTOMY PAIN: A RANDOMISED CONTROL STUDY
Authors: Sahu Abhishek , Hajare Priti , Mudhol Ramesh , Harugop Anil , Shiromony Amol , Menon Smrithi , Mitra Monali
Published: November 2022

Pain is a significant hindrance to the rehabilitation of a patient following tonsillectomy. This necessitates the need for adequate pain control to avoid poor oral intake, delayed recovery and prolonged hospitalization. The objective of the study is to compare the analgesic effect of Diclofenac sodium alone and combination of Paracetamol and Ibuprofen in controlling post tonsillectomy pain.The study also compares improvement in post tonsillectomy pain in patients above and below 15 years of age andto determine the duration of analgesic required. This is a Randomized Control study conducted in a tertiary care center. The study which spanned over a period of 6 months included 68 post tonsillectomy patientsin the age group of 5 to 30 years who were randomly allocated into two groups. One group was subjected to oral Diclofenac sodium while the other received a combination of Paracetamol and Ibuprofen. The study concluded that combining two analgesics for pain improvement in post tonsillectomy patients appears to be more effective, requires lesser dosage of individual drugs and causes lesser side effects than single drug therapy. With appropriate dosage of analgesics, post- tonsillectomy morbidity can be significantly reduced, reducing the duration of therapy in all age groups
C-REACTIVE PROTEIN IN NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
Authors: Dawar Rajni , Yasmin Tabassum
Published: November 2022

Prevalence of Non Alcoholic Fatty Liver Disease is estimated to be around 9-32% in general Indian Population.It is more common in diabetic and obese Indiviuals. We conducted a case control study in RMCH ,a tertiary care hospital with 36 patients of diagnosed NAFLD and 30 age & sex matched controls.BMI was calculated for all subjects. Serum hs-C Reactive Protein levels were estimated by ELISA. It was found that BMI (29.61±4.89 ;23.66±3.4,p<0.001 ) and hs-CRP levels (8.9±.16; 2.3±1.6 ,p

<0.001)were significantly higher in cases compared to controls .As hs- CRP is an independent factor involved in CAD and metabolic Syndrome, it signifies increased risk of these in NAFLD. We also advocate its use for diagnostic workup & its further evaluation as a marker for NAFLD.>
HISTOMORPHOLOGICAL AND MORPHOMETRICAL CHANGES OF PLACENTAL TERMINAL VILLI OF NORMOTENSIVE AND HYPERTENSIVE MOTHERS
Authors: Madhu L , Karthavya S L , Lepakshi B G
Published: November 2022

Background & Objectives: Placental examination has clinical value in preeclampsia (PE) and IUGR. The luminal diameter of the uterine spiral arterioles in women with PE is narrowed leading to placental ischemia thus causing fetal hypoxia and pathological changes in placenta. The main objective of the present study is to compare morphological and histomorphometrical changes in placentas of preeclamptic and normotensive mothers. Methods: 50 placentas from both vaginal and LSCS delivery were collected at Dept. of OBG in a tertiary care center, half of them from normotensive pregnancies and the rest from preeclamptic mothers. An inclusion criterion for control was normal blood pressure and no proteinuria. Exclusion criteria for both control and study group was DM, obesity, severe anemia or any systemic disorders. Placental thickness, weight, diameter and surface area were recorded. Histopathological sections stained with H&E were observed for surface area and diameter of TV. Results: The mean placental weight in PE was 430 g. The placental diameter was decreased in PE (16 cm) compared to controls (19 cm). Neonatal weight followed the same trend. Histologically, the changes in the TV and blood vessels was significant; there was decrease in the diameter of villi in PE cases(0.01 μm) when compared to controls (0.05 μm). There was significant decrease in the diameter of blood vessels in PE (0.0049 μm) than in controls (0.01 mm). Conclusion: This study has revealed that there are significant changes in the placenta in cases of PE both morphologically and histologically. There is also a need for further studies to prove the molecular and genetic factors involved in preeclampsia.
MOLECULAR STRATIFICATION OF LUNG ADENOCARCINOMA USING GENE EXPRESSION
Authors: Indugu Nagaraju , Pitta D W , Subbaiah G Venkata , Reddy K Jagadeeswara , Reddy C Damodar , Reddy K Satyavelu
Published: November 2022

Molecular stratification of tumors is essential for developing personalized therapies. Although patient stratification strategies have been successful; computational methods to accurately translate the gene-signature from high-throughput platform to a clinically adaptable low-dimensional platform are currently lacking. Here, we describe bioinformatics method for identification of biomarkers in lung adenocarcinoma using unsupervised clustering of TCGA (the Cancer Genome Altas Consortium) samples, based on gene-expression profiles, recaptured the three molecular subgroups but switched the subtype for 14% of the samples, resulting in significant (P = 0.000344) survival differences among the refined subgroups. Our results were able to define three subgroups of lung adennocarcinoma that differed not only in gene expression patterns, but also in clinical properties, including patient survival.
GENETIC RISK FACTORS ASSOCIATED WITH THROMBOSIS IN A SAMPLE OF IRAQ POPULATION
Authors: Ramadhan Rehab S , Abdullah Muhanad N
Published: November 2022

This study aimed to investigate the association of F5 gene Single Nucleotide Polymorphism (SNP) with the incidence of thrombosis. Blood samples were collected from 40 patients during the period from November 2014 to January 2015, from Critical Care Unit (CCU) of (Yarmook Hospital, Kadhimiya Hospital), as well as from 10 unrelated healthy control group. This study found the age group between 50 to 60 are more susceptible to thrombosis 45% and the thrombosis was more frequent in male 55% from female 45% the significant (p<0.01). Deoxyribonucleic acid (DNA) was extracted from whole blood samples, whereas, serum samples were analyzed using troponin test (TNT) for detection of thrombosis. Polymerase Chain Reaction (PCR) was achieved on extracted DNA using eleven specific primers for F5 gene :the first primer (Fve3) with product size (228bp), second primer (Fve4) with product size (310bp), third primer (Fve6) with product size(547bp), fourth primer (Fve7) with product size (241bp), fifth primer (Fve8) with product size (306bp), sixth primer (Fve12) with product size (286bp), seventh primer (Fve13a) with product length (260bp), eighth primer (Fve13c) with product size (317bp), ninth primer (Fve15) with product size (600bp), tenth primer (Fve16) with product size (333bp) and eleventh primer (Fve25) with product size (390bp). PCR products of F5 gene were sequenced. Result found to be change in DNA which was mostly SNP. This change was in three types: substitution 24.86%, insertion 28.57% and deletion 28.57%, a Leiden mutation was also identified among patients><0.01) Deoxyribonucleic acid (DNA) was extracted from whole blood samples, whereas, serum samples were analyzed using troponin test (TNT) for detection of thrombosis. Polymerase Chain Reaction (PCR) was achieved on extracted DNA using eleven specific primers for F5 gene :the first primer (Fve3) with product size (228bp), second primer (Fve4) with product size (310bp), third primer (Fve6) with product size(547bp), fourth primer (Fve7) with product size (241bp), fifth primer (Fve8) with product size (306bp), sixth primer (Fve12) with product size (286bp), seventh primer (Fve13a) with product length (260bp), eighth primer (Fve13c) with product size (317bp), ninth primer (Fve15) with product size (600bp), tenth primer (Fve16) with product size (333bp) and eleventh primer (Fve25) with product size (390bp). PCR products of F5 gene were sequenced. Result found to be change in DNA which was mostly SNP. This change was in three types: substitution 24.86%, insertion 28.57% and deletion 28.57%, a Leiden mutation was also identified among patients
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF COBICISTAT AND DARUNAVIR IN BULK AND PHARMACEUTICAL DOSAGE FORM
Authors: Sankarshana T , Musthafa Md.
Published: November 2022

A stability indicating RP-HPLC method has been developed and subsequently validated for the simultaneous estimation of cobicistat and darunavir in API and tablet dosage form. Optimized chromatographic condition were achieved by Eclipse XBD-C18(250mm x 4.6mm, 5µ) column, mobile phase as a mixture of buffer (0.01M potassium dihydrogen phosphate, pH-3.0): acetonitril in the ratio of 40:60v/v with a flow rate of 1ml/min., UV detection was performed at 240nm and the sample temperature was maintained ambient which was injected manually. This developed method for simultaneous estimation of cobicistat and darunavir is linear over a range of 40 – 120 % and 40 -120 % respectively. The validation parameters as per ICH guide lines show good precision having 0.066 and 0.039 %RSD for cobicistat and darunavir which shows nice repeatability, limit of detection and limit of quantification for cobicistat and darunavir was found to be 0.02 and 0.06 and 0.02 and 0.06 % respectively. The developed method is easy to perform assay for indicating quality control determinations in bulk and formulated form with rapid, selective and stability indicating
PHARMACIST LEAD PATIENT COUNSELLING: IMPACT ON QUALITY OF LIFE IN ASTHMA PATIENTS
Authors: Linu Mohan P
Published: November 2022

Safe and effective drug therapy depends on patients being well informed about their medication. The proper use of drugs and patient education are vital for asthma management. Increasing patient’s knowl-edge about their asthma therapy is a necessary component of asthma management. This study was carried out to assess the patient counseling impact on quality of life (QOL) in asthma patients using SF 36questionnaire. In this study a total of hundred patients diagnosed with asthma were enrolled by considering the inclusion and exclusion criteria. Out of this, 50 (50%) patients were in intervention and 50 (50%) patients in the control group. As per our study it was found that the predominant risk factor for Asthma was fumes and smoking was found to be the major risk factor in males. After patient counseling intervention group showed improvement in QOL from the baseline to1st and 2nd follow-ups. But control group doesn’t show significant improvement in the QOL from the baseline to 1st and 2nd follow-ups. Physical activity and daily activity was also found to be increased during second follow-up in intervention group than in control group. Our study concluded that continuous education programs and counseling should be conducted for chronic diseases to emphasize and re-emphasize the importance of Quality of Life, to prevent recurrences, reduce progression of disease and ultimately minimize the hospitalization and there is a need of continuous pharmaceutical care services/ monitoring to improve the better quality of life.
Pharmacological Application of Moringa oleifera: A Mini Review
Authors: Meena Raghunandan , Porwal Omji , Tilak Vijay Kumar , Arya Rajeshwar Kamal Kant , Dhakar Ram Chand
Published: November 2022

All part of the Moringa tree is useful in some way and people depends on it for their livelihood. Oral diseases persist to be a major health problem all over the world. Various microorganisms are found to be the possible pathogens responsible for the oral diseases. The leaves of the Moringa tree are an excellent source of Nutrients like Minerals, Protein and Vitamins (A and C). Moringa tree has approximately 46 antioxidants and it is one of the cheapest sources of natural anti-oxidants. Anti-oxidants supply the free atoms needed by the human body and mitigate the effect of free radicals. M. oleifera contains active compounds such as flavonoids, tannins, saponins, alkaloids, phenolics, and triterpenoids which possess antibacterial effects. Moringa oleifera has high mineral and protein content and has been previously investigated for its potential in treating different oral soft tissue diseases.  This review explores the various pharmacological application of Moringa oleifera

Keywords: Moringa oleifera, Anti-oxidants, Minerals, Vitamins
GREEN SYNTHESIS AND EVALUATION OF SILVER NANOPARTICLES USING CYPERUS ROTUNDUS
Authors: Singh Harmeet , Sharma Tamanna
Published: November 2022

The study focuses on the green synthesis of silver nanoparticles using plant extract of Cyperus Rotundus as reducing, capping and stabilizing agent. Aqueous silver ions when exposed to plant tubers extract [Cyperus Rotundus] resulted in a color change indicating the formation of silver nanoparticles. The synthesized silver nanoparticles were characterized by UV-Vis spectrophotometer, Transmission Electron Microscopy (TEM) and Fourier Transform Infra-red Spectroscopy (FTIR) techniques. The UV-Vis spectra showed peak at 455 nm. TEM revealed that the synthesized silver nanoparticles are spherical and circular in morphology and ranges between 15nm to 100 nm. The particle size and zeta potential range of AgNPs monitored by particle size analyzer Mastsizer 2000 and result was found to be 15nm and -9.03mV. The plant extract of Cyperus Rotundus possess wound healing property which may further be potentiated in the presence of silver nanoparticles. Synthesized silver nanoparticles were incorporated into gel base and different formulations were prepared from F1 to F4 having different carbopol concentration, out of which F2 was found to be optimal and further evaluated for its physical properties such as pH, viscosity & spreadability. The results obtained in the developed formulation showed no lumps, had uniform color dispersion and were free from any fiber and particle. It was also observed to have easy wash ability, good spreadability. Hence, silver nanoparticle of Cyperus Rotundus in aqueous gel-base can be used as an appropriate formulation for Wound Healing.
A Complete Review on Aromatherapy: A Complementary Alternative Medication Therapy with Recent Trend
Authors: Nema Prakhar , Jain Sameeksha , Vishwakarma Harshna , Purohit Arpana , Jain Prateek Kumar
Published: November 2022

Aromatherapy is one of the most actively growing forms of alternative medicines that use essential oils and aromatic plant compounds combining massage together with counselling and nice odour. Aromatherapy using essential oils can help to relieve stress and anxiety symptoms, which may help improve sleep indirectly. A study found aromatherapy improved both depression and anxiety in a group of post - partum women. Aromatherapy can do more than soothe your mind. Scientific studies show that aromatherapy- inhaling or absorbing aromatic plants extracts also may help soothe your body and relieve pain. Studies have shown that essential oils have an effect on brainwaves and also alter behaviour. It is possible that most of the effect of the oils is probably transmitted through the brain via the olfactory system. Used professionally and safely, aromatherapy can be of great benefit as an adjunct to conventional medicine or used simply as an alternative.
Keywords: Aromatherapy, Essential oils, Alternative medicines
Evaluation of anti-diabetic activity of different extracts of Corchorus trilocularis in STZ induced diabetes in rats
Authors: Bhatnagar Anil Kumar , Jain Neetesh Kumar , Singhal Rohit , Silawat Narendra
Published: November 2022

Aim- The main aim of the present study is to evaluate the anti-diabetic study of different extracts of Corchorus trilocularis in STZ induced diabetes in rats. Material and Methods- Powdered drug 500 gm was weighed and packed in soxhlet. The drug was continuously extracted with petroleum ether for about 72 hours. Complete defatting was ensured by placing a drop form the thimble on a filter paper give any oily spot. The mark was dried in air to remove traces of petroleum ether. Defatted mark was subjected to extraction with ethyl acetate in soxhlet apparatus and then again extracted by using ethanol, butanol and finally by using water. Acute oral toxicity test was carried out according to the OECD guideline No. 423. After fasting 18 hours, the rats were injected intraperitoneal injection through tail vein with a single dose of 40 mg/kg Streptozocin, freshly dissolved in citrate buffer (pH 4.5). Then serum samples were also used to analyze for serum Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C) and Very Low Density Lipoprotein Cholesterol (VLDL-C) and atherogenic index (AI). Results- Petroleum ether, ethanolic and butanolic extracts had moderately significant effects (p<0.01) on 14th and 21st days. However, aqueous extracts showed significant effect (p<0.05) in glucose levels. The effect of aqueous extract is very less as compared to other extracts. Conclusion- The present investigation comprises of the phytochemical and pharmacological investigations of leaves of Corchorus trilocularis for the antidiabetic activity.
Keywords- Anti-diabetic, Different extracts, Corchorus trilocularis, STZ induced diabetes, (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), Very Low Density Lipoprotein Cholesterol (VLDL-C)
Ethanolic Extracts of leaves of Alstonia scholaris Linn. Modulates Chronic Inflammatory Immune Response in FCA Induced Arthritis
Authors: Dasoundhi Ritika , Jain Neetesh Kumar , Singhal Rohit , Silawat Narendra
Published: November 2022

AIM- The aim of the present investigation is scientifically establishing the anti-arthritic activity of selected medicinal plant so that we are able to come up with a more effective and potent bioactive phytoconstituents with less side effects in comparison with existing synthetic drugs. MATERIAL & METHODS- The leaves of Alstonia scholaris were collected from campus of College of Pharmacy. All the plant materials were taxonomically identified by Dr. Gyanendra Tiwari, Senior Scientist, KNK College of Horticulture. All the plant materials were dried under shade and subjected to coarse powder for extraction process. Accurately weighed quantity of leaf powder of Alstonia scholaris were extracted using 95 % ethanol by soxhlet apparatus for 72 h. The ethanolic extracts were dried under the reduced pressure to get crude ethanolic extracts. The Wistar albino rats were divided into 10 groups of six animals in each. For the induction of chronic inflammatory response, FCA (0.1 ml) was injected through intra-articular injection in left ankle joint of rats on 0 day. The severity of adjuvant arthritis was quantified by measuring the volume of the hind paw using Plethysmograph. Body weight was measured of all groups at zero days before immunization and at 21st day after treatments over by using a single pan weighing balance. RESULTS- The preliminary phytochemical analysis revealed that different active constituent present in different extracts such as carbohydrates, proteins, amino acids, fat, oils, steroids, terpenoids, glycosides, alkaloids, tannins and other phenolics compounds. The assessment made on the 21st day showed that the A. scholaris treatments at both doses (low and high) had moderately significant and highly significant effect and reduced (p< 0.01& p<0.001) the adjuvant-induced lesions in the respective treatment groups as compared with the arthritis control group. However, standard, A. scholaris had highly significant effects (p<0.001) in recovery of RBCs and haemoglobin. They also showed highly significant effects on decrease in WBCs and ESR treated groups, also showed moderately significant effects as compared to arthritic group. CONCLUSION- Besides from the obvious therapeutic importance, these components would be useful in understanding the mechanism of diseases with higher levels of cellular and molecular level. These components could serve as lead molecules for development of prospective anti-arthritic agents.
Keywords: Anti-arthritic agent, Lead molecules, Alstonia scholaris, Shronic inflammatory response, Synthetic drugs, Plethysmograph
Synthesis, Characterization and Anti-Diabetic Activity of Novel 2-Substituted Indole Derivatives
Authors: Tomar Aman Singh , Khan Neelam , Jain Neetesh Kumar
Published: November 2022

Accordingly, the nitrogen in each nucleus, viz. 2-phenylindole, carbazole, phenothiazine and dibenzylamine, was planned to be alkylated applying several N-­alkylating conditions, using either bromochloropropane or bromochlorobutane to give alkylated products with chloro-group available at the end of 2-carbon and 3-carbon chain. The chloro-group can then thought be utilized in reaction with p-hydroxyacetophenone to form ethereal linkage, by applying conditions of Williamson’s ether synthesis. The acetyl group present in the products could then easily be converted into indole ring using conditions of Fischer’s-indole synthesis.57 Further, it was planned to confirm the structures of synthesized compounds using spectral and elemental analysis, apart from simple laboratory techniques like physical constants and classical chemical tests.
Keywords: Indole, 2-Phenylindole, Carbazole, Diabetes, Anti-diabetic activity.
Synthesis, Characterization and Antidiabetic Activity of New Pyrimidine Fused Derivatives
Authors: Patidar Pankaj , Chaturvedi Prerna , Jain Neetesh Kumar
Published: November 2022

Various evidences suggest that common health problem of modern society, viz. diabetes mellitus, obesity, cardiovascular diseases etc. The prevalence of diabetes mellitus in majority increases with age and obesity; over 20 % adults (≥ 60 years or older) have diabetes. Synthesis of starting materials by Noevenagel Condensation then A reaction mixture of different benzylidine propanednitriles 1a-d (10 mmol), alkylisothiourea salts (11.00 mmol) and sodium acetate anhydrous (2.50 g, 24.40 mmol) in pyridine (50 ml) was refluxed for 3 hrs, and crystallized from ethanol give compound 2a-d. then 2-Methylthiopyrimidines 2a-d (5.0 mmol) was heated under reflux overnight with 5 mL of the appropriate amine (2-phenylethylamine or cyclohexylamine, and crystallized from appropriate solvent give compound 3a-d. synthesized derivatives characterized by IR, NMR and Mass spectrophotometry and evaluated for anti-diabetic activity.
Keywords: diabetes mellitus, anti-diabetic activity, pyrimidine derivatives, Noevenagel Condensation.
Synthesis, Characterization and Anti-Convulsant Activity of Novel Substituted Oxadiazole Derivatives
Authors: Sikarwar Saurav Singh , Daniel Kratika , Jain Neetesh Kumar
Published: November 2022

Seizures are sudden, transitory, and uncontrolled episodes of brain   dysfunction resulting from abnormal discharge of neuronal cells with associated motor, sensory or behavioral changes. Anticonvulsants (also commonly known as antiepileptic drugs or as ant seizure drugs) are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder, since many seem to act as mood stabilizers, and for the treatment of neuropathic pain. Anticonvulsants suppress the rapid and excessive firing of neurons during seizures. Anticonvulsants also prevent the spread of the seizure within the brain. Synthesis of starting material by reacting with KOH resulting substituted benzoate obtained then (2.58gm, 10 m mol)  DMF (10 ml), hydrazine hydrate (50 m mol) was added give substituted hydrazide product  then take methanolic solution of hydrazide product (5.1 m mol), cyanogens bromide (7.5 m mol) was added give  oxadiazole derivatives, The purity of all compounds have been checked by the TLC monitoring and the conformation of structure will be checked by different spectra like IR, Mass and NMR, and then evaluated for anti-convulsant activity.
Keywords: Oxadiazole, Oxadiazole derivatives, Convulsion, Anti-convulsant activity.
To Synthesize Naphthalene Derivatives Having Isoxazole Central Core as Anti- Microbial Agents
Authors: Chavan Uma , Daniel Kratika , Jain Neetesh Kumar
Published: November 2022

The presence of heterocycles such as pyrrole, thiazole, oxazole, furane, imidazole, and isoxazole and pyrimidine nucleus as central scaffold is a common feature in the chemical structure of several antimicrobial agents. So the aim has been designed to synthesize the molecule having Naphthalene ring in one of diaryl having isoxazole as pharmacophoric heterocyclic moiety for synthesis of safer anti-microbial agents.
Keywords: Naphthalene, isoxazole, anti-microbial agents.