bluuebunny/crossref_metadata_2025 huggingface dataset:
A Prospective Cohort Study Assessing the Relationship between Plasma Levels of Osimertinib and Treatment Efficacy and Safety
Authors: Fukuhara Tatsuro , Imai Kazuhiro , Nakagawa Taku , Igusa Ryotaro , Yokota Hayato , Watanabe Kana , Suzuki Aya , Morita Mami , Onodera Ren , Inoue Akira , Miura Masatomo , Minamiya Yoshihiro , Maemondo Makoto
Published: September 2023

Osimertinib is a standard treatment for patients with EGFR-mutated non-small cell lung carcinoma (NSCLC). We evaluated the relationship between plasma osimertinib concentrations and treatment outcome in patients with NSCLC for this cohort study. The plasma levels of osimertinib and its metabolite AZ5104 were measured a week after the start of treatment (P1). The primary endpoint was to evaluate the correlation between plasma concentration and adverse events (AEs). The correlation with treatment efficacy was one of the secondary endpoints. In patients with CNS metastases, the concentration in the cerebrospinal fluid was also measured. Forty-one patients were enrolled. The frequency of AEs was highest for rash, followed by anorexia and thrombocytopenia. Thirty-eight cases provided measurements for P1. The median plasma concentration of osimertinib was 227 ng/mL, and that of AZ5104 was 16.5 ng/mL. The mean CNS penetration rate of two cases was 3.8%. The P1 in the group with anorexia was significantly higher than that in the group without anorexia (385.0 ng/mL vs. 231.5 ng/mL, p = 0.009). Divided into quartiles by P1 trough level, Q2 + Q3 (164–338 ng/mL) had longer PFS, while Q1 and Q4 had shorter PFS. An appropriate plasma level of osimertinib may avoid some adverse events and induce long PFS. Further large-scale trials are warranted.
Novel Approach in Rectovaginal Fistula Treatment: Combination of Modified Martius Flap and Autologous Micro-Fragmented Adipose Tissue
Authors: Dimova Ana , Erceg Ivkošić Ivana , Brlek Petar , Dimov Stefan , Pavlović Tomislav , Bokun Tomislav , Primorac Dragan
Published: September 2023

In this paper, we introduce an innovative therapeutic approach for managing rectovaginal fistulas (RVF), by combining the modified Martius flap and micro-fragmented adipose tissue (MFAT) enriched with mesenchymal stem cells (MSC). This novel approach aims to deal with the difficulties associated with RVF, a medically complex condition with a lack of effective treatment options. We present the case of a 45-year-old female patient with a 15-year history of Crohn’s disease (CD). During the preceding eight years, she had encountered substantial difficulties resulting from a rectovaginal fistula (RVF) that was active and considerable in size (measuring 3.5 cm in length and 1 cm in width). Her condition was accompanied by tissue alterations at both the vaginal and rectal openings. Following her admission to our hospital, the patient’s case was discussed during both surgical and multidisciplinary hospital team (IRB) meetings. The team decided to combine a modified Martius flap with autologous MFAT containing MSCs. The results were remarkable, leading to comprehensive anatomical and clinical resolution of the RVF. Equally significant was the improvement in the patient’s overall quality of life and sexual satisfaction during the one-year follow-up period. The integration of the modified Martius flap with MFAT emerges as a highly promising approach for addressing CD-related RVFs that had historically been, and still are, difficult to treat, given their often refractory nature and low healing success rates.
Extraordinarily Stable Hairpin-Based Biosensors for Rapid Detection of DNA Ligases
Authors: Wu Ziang , Kou Roujuan , Ni Kun , Song Rui , Li Yuxuan , Li Tianhu , Zhang Hao
Published: September 2023

DNA ligases are essential enzymes involved in DNA replication and repair processes in all organisms. These enzymes seal DNA breaks by catalyzing the formation of phosphodiester bonds between juxtaposed 5′ phosphate and 3′ hydroxyl termini in double-stranded DNA. In addition to their critical roles in maintaining genomic integrity, DNA ligases have been recently identified as diagnostic biomarkers for several types of cancers and recognized as potential drug targets for the treatment of various diseases. Although DNA ligases are significant in basic research and medical applications, developing strategies for efficiently detecting and precisely quantifying these crucial enzymes is still challenging. Here, we report our design and fabrication of a highly sensitive and specific biosensor in which a stable DNA hairpin is utilized to stimulate the generation of fluorescence signals. This probe is verified to be stable under a wide range of experimental conditions and exhibits promising performance in detecting DNA ligases. We anticipate that this hairpin-based biosensor will significantly benefit the development of new targeting strategies and diagnostic tools for certain diseases.
Repetitive, but Not Single, Mild Blast TBI Causes Persistent Neurological Impairments and Selective Cortical Neuronal Loss in Rats
Authors: Campos-Pires Rita , Ong Bee Eng , Koziakova Mariia , Ujvari Eszter , Fuller Isobel , Boyles Charlotte , Sun Valerie , Ko Andy , Pap Daniel , Lee Matthew , Gomes Lauren , Gallagher Kate , Mahoney Peter F. , Dickinson Robert
Published: September 2023

Exposure to repeated mild blast traumatic brain injury (mbTBI) is common in combat soldiers and the training of Special Forces. Evidence suggests that repeated exposure to a mild or subthreshold blast can cause serious and long-lasting impairments, but the mechanisms causing these symptoms are unclear. In this study, we characterise the effects of single and tightly coupled repeated mbTBI in Sprague–Dawley rats exposed to shockwaves generated using a shock tube. The primary outcomes are functional neurologic function (unconsciousness, neuroscore, weight loss, and RotaRod performance) and neuronal density in brain regions associated with sensorimotor function. Exposure to a single shockwave does not result in functional impairments or histologic injury, which is consistent with a mild or subthreshold injury. In contrast, exposure to three tightly coupled shockwaves results in unconsciousness, along with persistent neurologic impairments. Significant neuronal loss following repeated blast was observed in the motor cortex, somatosensory cortex, auditory cortex, and amygdala. Neuronal loss was not accompanied by changes in astrocyte reactivity. Our study identifies specific brain regions particularly sensitive to repeated mbTBI. The reasons for this sensitivity may include exposure to less attenuated shockwaves or proximity to tissue density transitions, and this merits further investigation. Our novel model will be useful in elucidating the mechanisms of sensitisation to injury, the temporal window of sensitivity and the evaluation of new treatments.
Impacts of Mn Content and Mass Loading on the Performance of Flexible Asymmetric Solid-State Supercapacitors Using Mixed-Phase MnO2/N-Containing Graphene Composites as Cathode Materials
Authors: Chiu Hsin-Ya , Cho Chun-Pei
Published: September 2023

MnO2/nitrogen-containing graphene (x-NGM) composites with varying contents of Mn were used as the electrode materials for flexible asymmetric solid-state supercapacitors. The MnO2 was a two-phase mixture of γ- and α-MnO2. The combination of nitrogen-containing graphene and MnO2 improved reversible Faraday reactions and charge transfer. However, excessive MnO2 reduced conductivity, hindering ion diffusion and charge transfer. Overloading the electrode with active materials also negatively affected conductivity. Both the mass loading and MnO2 content were crucial to electrochemical performance. x-NGM composites served as cathode materials, while graphene acted as the anode material. Operating by two charge storage mechanisms enabled a synergistic effect, resulting in better charge storage purposes. Among the supercapacitors, the 3-NGM1//G1 exhibited the highest conductivity, efficient charge transfer, and superior capacitive characteristics. It showed a superior specific capacitance of 579 F·g−1, leading to high energy density and power density. Flexible solid-state supercapacitors using x-NGM composites demonstrated good cycle stability, with a high capacitance retention rate of 86.7% after 2000 bending cycles.
Acceptability and Usability of the Family Gene Toolkit for Swiss and Korean Families Harboring BRCA1/BRAC2 Pathogenic Variants: A Web-Based Platform for Cascade Genetic Testing
Authors: Baroutsou Vasiliki , Duong Vu , Signorini Alice , Saccilotto Ramon , Ciorba Florina M. , Bürki Nicole , Caiata-Zufferey Maria , Ryu Jai Min , Kim Sung-Won , Lim Myong Cheol , Monnerat Christian , Zürrer-Härdi Ursina , Kim Jisun , Heinimann Karl , Graffeo Rossella , Park Ji Soo , Rabaglio Manuela , Chappuis Pierre Olivier , Kim Sue , Katapodi Maria C. ,   on behalf of the CASCADE and K-CASCADE Consortia
Published: September 2023

The study adapted the Family Gene Toolkit and developed a customized web application for Swiss and Korean families harboring BRCA1 or BRCA2 pathogenic variants to support family communication of genetic testing results and promote cascade genetic testing among at-risk relatives. In the first step, narrative data from 68 women with BRCA1/BRCA2 pathogenic variants and clinician feedback informed a culturally sensitive adaptation of the content consistent with current risk management guidelines. In the second step, the Information Technology team developed the functions and the interface of the web application that will host the intervention. In the third step, a new sample of 18 women from families harboring BRCA1/BRCA2 pathogenic variants tested the acceptability and usability of the intervention using “think-aloud” interviews and a questionnaire. Participants expressed high levels of satisfaction with the intervention. They provided positive feedback for the information regarding active coping, strategies to enhance family communication, interactive elements, and illustrative stories. They reported that the information was useful and the web application was easy to navigate. Findings suggest that the Family Gene Toolkit is well-designed and can increase rates of cascade testing among at-risk relatives. Its efficacy will be tested in a subsequent randomized trial.
Lifestyle and Clinical Factors in a Nationwide Stage III and IV Renal Cell Carcinoma Study
Authors: Azawi Nessn , Ebbestad Freja Ejlebaek , Nadler Naomi , Mosholt Karina Sif Soendergaard , Axelsen Sofie Staal , Geertsen Louise , Christensen Jane , Jensen Niels Viggo , Fristrup Niels , Lund Lars , Donskov Frede , Dalton Susanne Oksbjerg
Published: September 2023

Background: The aim was to investigate whether patient-related or clinical risk factors present at the diagnosis of advanced stage renal cell carcinoma (RCC) had an impact on the overall mortality, cancer-specific mortality, and recurrence risk in a national cohort. Methods: Patients registered with stage III and IV RCC in the Danish Renal Cancer Database (DaRenCa) in 2014–2016 were included in the study and followed up until recurrence or death. We conducted a Cox Proportional Hazard Model to examine the association between several variables and the development of RCC. These variables included BMI, hypertension, smoking status, symptoms at diagnosis, performance status, multidisciplinary team (MDT) discussion, surgical margin, and primary metastasis. Separate analyses were performed for cc-RCC and non-ccRCC patients. Results: In our cohort of 929 patients, 424 individuals died from RCC during the follow-up period, with a median follow-up time of 4.1 (95% CI: 0.8–5.0) years for ccRCC and 2.0 (95% CI: 0.1–5.0) years for non-ccRCC. A multivariate analysis demonstrated that a positive surgical margin (HR 1.53 and 1.43), synchronous metastasis (HR 2.06 and 3.23), and poor performance status (HR 4.73 and 5.27) were significantly associated with a decreased 5-year overall and cancer-specific survival, respectively. Furthermore, a positive surgical margin was associated with a higher risk of recurrence in ccRCC. MDT discussion was found to reduce mortality risk in non-ccRCC. Conclusion: Clinical- and disease-related variables have a greater impact on RCC mortality and recurrence than the selected lifestyle-related factors. The inclusion of MDT discussion in the diagnosis and management of advanced RCC should be further evaluated for its potential to improve patient outcomes.
Outcome of Completion Surgery after Endoscopic Submucosal Dissection in Early-Stage Colorectal Cancer Patients
Authors: Dekkers Nik , Dang Hao , Vork Katinka , Langers Alexandra M. J. , van der Kraan Jolein , Westerterp Marinke , Peeters Koen C. M. J. , Holman Fabian A. , Koch Arjun D. , de Graaf Wilmar , Didden Paul , Moons Leon M. G. , Doornebosch Pascal G. , Hardwick James C. H. , Boonstra Jurjen J.
Published: September 2023

T1 colorectal cancers (T1CRC) are increasingly being treated by endoscopic submucosal dissection (ESD). After ESD of a T1CRC, completion surgery is indicated in a subgroup of patients. Currently, the influence of ESD on surgical morbidity and mortality is unknown. The aim of this study was to compare 90-day morbidity and mortality of completion surgery after ESD to primary surgery. The completion surgery group consisted of suspected T1CRC patients from a multicenter prospective ESD database (2014–2020). The primary surgery group consisted of pT1CRC patients from a nationwide surgical registry (2017–2019). Patients with rectal or sigmoidal cancers were selected. Patients receiving neoadjuvant therapy were excluded. Propensity score adjustment was used to correct for confounders. In total, 411 patients were included: 54 in the completion surgery group (39 pT1, 15 pT2) and 357 in the primary surgery group with pT1CRC. Adverse event rate was 24.1% after completion surgery and 21.3% after primary surgery. After completion surgery 90-day mortality did not occur, though one patient died in the primary surgery group. After propensity score adjustment, lymph node yield did not differ significantly between the groups. Among other morbidity-related outcomes, stoma rate (OR 1.298 95%-CI 0.587-2.872, p = 0.519) and adverse event rate (OR 1.162; 95%-CI 0.570-2.370, p = 0.679) also did not differ significantly. A subgroup analysis was performed in patients undergoing rectal surgery. In this subgroup (37 completion and 136 primary surgery), these morbidity outcomes also did not differ significantly. In conclusion, this study suggests that ESD does not compromise morbidity or 90-day mortality of completion surgery.
Treatment of Clival Chordomas: A 20-Year Experience and Systematic Literature Review
Authors: Noya Carolina , D’Alessandris Quintino Giorgio , Doglietto Francesco , Pallini Roberto , Rigante Mario , Mattogno Pier Paolo , Gessi Marco , Montano Nicola , Parrilla Claudio , Galli Jacopo , Olivi Alessandro , Lauretti Liverana
Published: September 2023

Clival chordomas are rare but aggressive skull base tumors that pose significant treatment challenges and portend dismal prognosis. The aim of this study was to highlight the advantages and limitations of available treatments, to furnish prognostic indicators, and to shed light on novel therapeutic strategies. We conducted a retrospective study of clival chordomas that were surgically treated at our institution from 2003 to 2022; for comparison purposes, we provided a systematic review of published surgical series and, finally, we reviewed the most recent advancements in molecular research. A total of 42 patients underwent 85 surgeries; median follow-up was 15.8 years, overall survival rate was 49.9% at 10 years; meanwhile, progression-free survival was 26.6% at 10 years. A significantly improved survival was observed in younger patients (<50 years), in tumors with Ki67 ≤ 5% and when adjuvant radiotherapy was performed. To conclude, clival chordomas are aggressive tumors in which surgery and radiotherapy play a fundamental role while molecular targeted drugs still have an ancillary position. Recognizing risk factors for recurrence and performing a molecular characterization of more aggressive lesions may be the key to future effective treatment.
Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them?
Authors: Sokol Olga , Durante Marco
Published: September 2023

Hypoxia, which is associated with abnormal vessel growth, is a characteristic feature of many solid tumors that increases their metastatic potential and resistance to radiotherapy. Carbon-ion radiation therapy, either alone or in combination with other treatments, is one of the most promising treatments for hypoxic tumors because the oxygen enhancement ratio decreases with increasing particle LET. Nevertheless, current clinical practice does not yet fully benefit from the use of carbon ions to tackle hypoxia. Here, we provide an overview of the existing experimental and clinical evidence supporting the efficacy of C-ion radiotherapy in overcoming hypoxia-induced radioresistance, followed by a discussion of the strategies proposed to enhance it, including different approaches to maximize LET in the tumors.
Single-Isocenter Linac-Based Radiosurgery for Brain Metastases with Coplanar Arcs: A Dosimetric and Clinical Analysis
Authors: Faccenda Valeria , Panizza Denis , Pisoni Valerio , Trivellato Sara , Daniotti Martina Camilla , Bianchi Sofia Paola , De Ponti Elena , Arcangeli Stefano
Published: September 2023

The efficacy of linac-based SRS/fSRS treatments using the single-isocenter coplanar FFF-VMAT technique for both single and multiple BM was investigated. Seventy patients (129 BM) treated with 15–21 Gy in 1 (n = 59) or 27 Gy in 3 (n = 11) fractions were analyzed. For each fraction, plans involving the intra-fractional errors measured by post-treatment CBCT were recalculated. The relationships of BM size, distance-to-isocenter, and barycenter shift with the difference in target coverage were evaluated. Clinical outcomes were assessed using logistic regression and Kaplan-Meier analysis. The median delivery time was 3.78 min (range, 1.83–9.25). The median post-treatment 3D error was 0.5 mm (range, 0.1–2.7) and the maximum rotational error was 0.3° (range, 0.0–1.3). In single BM patients, the GTV D95% was never reduced by >5%, whereas PTV D95% reductions >1% occurred in only 11 cases (29%). In multiple BM patients, dose deficits >5% and >1% occurred in 2 GTV (2%) and 34 PTV (37%), respectively. The differences in target coverage showed a moderate-to-strong correlation only with barycenter shift. Local failure of at least one treated BM occurred in 13 (21%) patients and the 1-year and 2-year local control rates for all lesions were 94% and 90%, respectively. The implemented workflow ensured that the degradation of target and brain dose metrics in delivered treatments was negligible. Along with encouraging clinical outcomes, these findings warrant a reduction in the PTV margins at our institution.
Survival and Response Outcomes for Gastrointestinal Neuroendocrine Tumor (GEP-NETs) Patients Treated with Lutetium—177-DOTATATE in a Brazilian Reference Center: A Six-Year Follow-Up Experience
Authors: de Souza Zenaide Silva , Xavier Camila Bragança , Gomes Luciana Beatriz Mendes , de Medeiros Maria Fernanda Barbosa , de Sousa Micelange Carvalho , Pereira Allan Andresson Lima , Marin José Flávio Gomes , Buchpiguel Carlos Alberto , Costa Frederico Perego
Published: September 2023

Background: PRRT can be an option for all-grade GEP-NETs, but selecting patients is challenging. In this scenario, clinical-pathological and radiological characteristics, such as pre-treatment Ga-68 DOTA PET/CT, might have the potential to help. Methods: A retrospective chart review was conducted on advanced GEP-NETs treated with at least one PRRT dose. Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan–Meier method. Krenning Score (KS), and the maximum standardized uptake value (SUVmax) were derived from the pre-treatment scans. A maximally selected rank statistics test was used for SUVmax simple cut point estimate. Results: Among 36 patients, 19 had primary pancreatic tumors. The numbers of G1, G2, and G3 tumors were 10, 18, and 7, respectively. During a median follow-up of 90.5 months, 4 patients died. Median OS was not reached for G1 and G2 tumors, and it was 30 months for G3 (p = 0.001). Median PFS was 23 months, with G3 showing lower PFS compared to G1 [7 versus 30 months; HR 8.41 (95%CI 2.2–31.0; p = 0.001)]. Conclusions: PRRT provides long-term PFS in patients with G1/G2 GEP-NETs independent of clinical characteristics and primary site. G3 has worse survival, but selected patients may experience long OS after PRRT treatment.
Recent Trends in Catalysis for Syngas Production and Conversion
Authors: Meng Fanhui , Mo Wenlong
Published: September 2023

Synthesis gas (or syngas) is a mixture of CO and H2 that can be produced from fossil fuels or biomass [...]
Sperm Concentration Improvement May Be a Parameter Predicting Efficacy of FSH Therapy of Male Idiopathic Infertility
Authors: Santi Daniele , Spaggiari Giorgia , Dalla Valentina Leonardo , Romeo Marilina , Nuzzo Federico , Serlenga Lorenzo , Roli Laura , De Santis Maria Cristina , Trenti Tommaso , Granata Antonio R. M. , Simoni Manuela
Published: September 2023

Testis stimulation with follicle-stimulating hormone (FSH) is one of the empirical treatments proposed for male idiopathic infertility, although reliable markers to predict its efficacy are still lacking. This study aimed to identify parameters able to predict FSH efficacy in terms of pregnancy achievement. A real-world study was conducted, enrolling idiopathic infertile men treated with FSH 150IU three times weekly. Patients were treated until pregnancy achievement or for a maximum of two years and two visits were considered: V0 (baseline) and V1 (end of FSH treatment). Primary endpoints were the V1-V0 percentage change in sperm concentration, total sperm count, and total motile sperm number. In total, 48 pregnancies were recorded (27.7%) among 173 men (age 37.9 ± 6.2 years). All three endpoints increased after FSH administration, and only the V1-V0 percentage of sperm concentration significantly predicted pregnancy (p = 0.007). A V1-V0 sperm concentration of 30.8% predicted pregnancy, and the sperm concentration V1-V0 percentage (Y) required to obtain a pregnancy was predicted according to its baseline values (x): Y = 9.8433x2 − 203.67x + 958.29. A higher number of pregnancies was reached in men with baseline sperm concentration below 7.3 million/mL. Thus, the percentage of sperm concentration increasing after FSH administration could predict the treatment efficacy in terms of pregnancy. At the dosage used, the efficacy was significantly higher in patients with a starting sperm concentration < 7.3 mill/mL. Mathematical analyses identified a function able to predict the sperm concentration increase required to obtain a pregnancy in relation to the baseline sperm number.
Effects of Combined Movement and Storytelling Intervention on Fundamental Motor Skills, Language Development and Physical Activity Level in Children Aged 3 to 6 Years: Study Protocol for a Randomized Controlled Trial
Authors: Vargas-Vitoria Rodrigo , Faúndez-Casanova César , Cruz-Flores Alberto , Hernandez-Martinez Jordan , Jarpa-Preisler Stefany , Villar-Cavieres Natalia , González-Muzzio María Teresa , Garrido-González Lorena , Flández-Valderrama Jorge , Valdés-Badilla Pablo
Published: September 2023

This study protocol aims to analyze and compare the effects of combined movement and storytelling intervention (CMSI) on fundamental motor skills (locomotor skills and object control), language development (language comprehension, language expression, vocabulary and language description), and physical activity levels (light intensity, moderate-to-vigorous intensity and sedentary time) in children aged 3 to 6 years. The sample will consist of 144 children from 12 class groups, randomly assigned to 3 experimental groups (n = 72 children) and 3 control groups (n = 72 children), belonging to 4 class groups of upper-middle-level classes (2 experimental and 2 control; 3 to 4 years), 4 transition level 1 classes (2 experimental and 2 control; 4 to 5 years) and 4 transition level 2 classes (2 experimental and 2 control; 5 to 6 years). The experimental groups will perform CMSI for 3 sessions per week (40 min per session) over 12 weeks (using one motor story per week), while the control groups will not receive any treatment. The main outcome will provide information about fundamental motor skills, language development, and physical activity levels. Our hypothesis indicates that CMSI has the potential to generate significant increases in selected assessments. If this intervention proves to be beneficial, it could contribute to preschool and school curricula.
Production and Preliminary Characterization of Linseed Mucilage-Based Films Loaded with Cardamom (Elettaria cardamomum) and Copaiba (Copaifera officinalis)
Authors: Treviño-Garza Mayra Z. , Saldívar-Vázquez Ana Karen , López-Villarreal Sonia Martha , Lara-Banda María del Refugio , Elizondo-Luevano Joel Horacio , Chávez-Montes Abelardo , Báez-González Juan Gabriel , Rodríguez-Luis Osvelia Esmeralda
Published: September 2023

In this research, developed linseed mucilage (M)-based films loaded with E. cardamom (MCA), C. officinalis (MCO), and co-loaded with both compounds (MCACO) were evaluated. The incorporation of the active compounds modified the color (redness–greenness, and yellowness); however, the thickness remained constant in all treatments (0.0042–0.0052 mm). In addition, the solubilization time of the films (in artificial saliva) to release the active compounds fluctuates between 9 and 12 min. Furthermore, the incorporation of bioactive compounds increased the total phenolic content and antioxidant activity (DPPH and ABTS, respectively), mainly in MCA (inhibition of 81.99 and 95.80%, respectively) and MCACO (inhibition of 47.15% and 39.73%, respectively). In addition, the incorporation of these compounds also decreased the hardness (39.50%–70.81%), deformation (49.16%–78.30%), and fracturability (39.58%–82.95%). On the other hand, it did not modify the adhesiveness, except in MCO. Moreover, SEM micrographs showed a more homogeneous structure in the MCO films among the films that contained CA in the formulation (heterogeneous structure with the presence of protuberances). Finally, due to the previously reported pharmacological properties of E. cardamomun and C. officinalis, the films developed in this study could have an application as a wound dressing in dentistry.
Preparation of Highly Durable Columnar Suspension Plasma Spray (SPS) Coatings by Pre-Oxidation of the CoNiCrAlY Bondcoat
Authors: Joeris Jana , Scheld Walter Sebastian , Uhlenbruck Sven , Sohn Yoo Jung , Sebold Doris , Guillon Olivier , Vaßen Robert
Published: September 2023

Columnar structured thermal barrier coatings (TBCs) have been intensively investigated due to their potential to enhance the durability and reliability of gas turbine engine components. These coatings consist of vertically aligned columns that provide excellent resistance to thermal cycling. In this study, the lifetime of columnar suspension-plasma-sprayed (SPS) TBCs was evaluated using burner rig tests. The tests were carried out under high-temperature conditions. Significantly, the pre-oxidation of the bondcoat during diffusion bonding treatment was found to have a substantial impact on the performance of the SPS TBCs. The optimized treatment resulted in columnar SPS TBCs demonstrating excellent thermal stability and resistance under the test conditions. The lifetime of the coatings was significantly extended compared to conventional TBCs by pre-oxidation of the CoNiCrAlY bondcoat in argon, which suggests that columnar SPS TBCs have great potential for use in gas turbine engines.
A Study of the Microstructure and Mechanical and Electrochemical Properties of CoCrFeNi High-Entropy Alloys Additive-Manufactured Using Laser Metal Deposition
Authors: Shao Guanghui , Lei Jiaxuan , Zhang Fenglong , Wang Shiyi , Hu Huiping , Wang Kai , Tan Ping , Yi Jianglong
Published: September 2023

This work demonstrates the successful additive manufacturing of an in situ-alloyed CoCrFeNi HEA with a single phase (FCC) structure via the laser metal deposition (LMD) technique. In this work, bulk specimens of the CoCrFeNi high entropy alloy (HEA) of size 15 mm × 15 mm × 45 mm were additive-manufactured (AMed). An H320-type additive-subtractive manufacturing all-in-one system with a 2 kW fiber laser with a coaxial nozzle head integrated in a five-axis CNC machine was used. The effect of varying laser powers (1000 W, 1300 W, and 1600 W) on the microstructure and mechanical and electrochemical properties of the AMed HEA specimens was investigated. The AMed specimens were analyzed for their microstructure, elemental distributions, microhardness, and mechanical and electrochemical properties. An increase in the laser power led to a non-uniform cooling rate and non-steady solidification rates of the molten area during the AM process. As a result, the crystal constant decreased, and the microhardness fluctuated within a narrow range across the specimen. Among the three laser powers, the AMed CoCrFeNi HEA at 1300 W had the optimal mechanical properties and the best electrochemical behavior in 3.5 wt.% NaCl solution.
Double Quantum Ring under an Intense Nonresonant Laser Field: Zeeman and Spin-Orbit Interaction Effects
Authors: Mora-Ramos Miguel E. , Vinasco Juan A. , Radu Adrian , Restrepo Ricardo L. , Morales Alvaro L. , Sahin Mehmet , Mommadi Omar , Sierra-Ortega José , Escorcia-Salas Gene Elizabeth , Heyn Christian , Duque Derfrey A. , Duque Carlos A.
Published: September 2023

We theoretically investigate the properties of an electron energy spectrum in a double GaAs-Al0.3Ga0.7As quantum ring by using the effective mass and adiabatic approximations, together with a realistic description of the confining potential profile, which is assumed to be deformed due to the application of an intense nonresonant laser field. The effects of the applied magnetic field and spin-orbit interaction are included. We discuss the features of the lowest confined energy levels under a variation of magnetic field strengths and intense laser parameters. The influence of this external probe on the linear optical absorption response associated with interlevel transitions is analyzed by considering both the presence and absence of spin-orbit effects.
Elliptical Quantum Rings with Variable Heights and under Spin–Orbit Interactions
Authors: Mora-Ramos Miguel E. , Vinasco Juan A. , Radu A. , Restrepo Ricardo L. , Morales Alvaro L. , Sahin Mehmet , Mommadi Omar , Sierra-Ortega José , Escorcia-Salas Gene Elizabeth , Duque Carlos A.
Published: September 2023

We investigate the electronic properties of a semiconductor quantum ring with an elliptical shape and non-uniform height, allowing for distributed quantum-dot-like bulges along its perimeter. The adiabatic approximation and the finite element method are combined to calculate the allowed electron states in the structure under the effective mass approximation, considering the contributions from Rashba and Dresselahaus spin–orbit interactions and the Zeeman effect in the presence of an applied magnetic field. We discuss the features of the calculated spectra for two different ring geometries: a symmetric one with four dot-like bulges, and an asymmetric one with three hilled protuberances. The information about those states allows us to evaluate the linear optical absorption response associated with interlevel transitions between the ground and lowest excited states. This phenomenon takes place at resonant energies of only a few milielectronvolts. It is observed that spin–orbit interactions tend to quench this response under zero-field conditions in the case of symmetric confinement.
Exploring the Impact of Zirconium Doping on the Mechanical and Thermodynamic Characteristics of Pt-40Rh Alloy through First-Principles Calculations
Authors: Li Fangzhou , Yuan Zhentao , Wang Xiao , Dai Hua , Hu Changyi , Wei Yan , Cai Hongzhong , Wang Xian , Gao Qinqin , Chen Jialin , Zhu Shaowu
Published: September 2023

Zirconium (Zr) element doping has proven to be an effective strategy for reinforcing the strength and toughness of Pt-Rh alloys. However, the incorporation of Zr into Pt-Rh alloy in solid solution form renders its microstructural observation challenging through experimental means, thus complicating the elucidation of its underlying mechanisms. Therefore, this study employs density functional theory-based first-principles calculations to investigate the mechanical and thermodynamic properties of Pt-40Rh-xZr (x = 0, 0.1, 0.5, 1.0) alloys. The results reveal that with an increasing Zr weight percentage, Young’s modulus, and hardness of Pt-40Rh-xZr alloys exhibit a trend of an initial decrease followed by a subsequent increase. Notably, at a Zr weight percentage of 1.0 wt.%, the alloy Pt-40Rh-1.0Zr demonstrates the highest Young’s modulus (329.119 GPa) and hardness (10.590 GPa). Concurrently, thermodynamic calculations indicate that as Zr content increases, the crystal thermal stability of Pt-40Rh-xZr alloys initially decreases before rising again. More specifically, the coefficient of thermal expansion for Pt-40Rh-1.0Zr is merely 89.518% of that observed in Pt-40Rh. These results imply that incorporating 1.0 wt.% Zr results in the most substantial enhancement in the comprehensive mechanical properties of the Pt-40Rh-xZr alloy. Consequently, this study offers theoretical insights that can guide the extended application of Pt-Rh alloys.
The Mitochondrial Genome of Littoraria melanostoma Reveals a Phylogenetic Relationship within Littorinimorpha
Authors: Chen Kun , Yang Mingliu , Duan Haisheng , Liao Xin
Published: September 2023

Littoraria melanostoma (Gray, 1839) is one of the most common species of gastropods in mangroves. They quickly respond during the early stage of mangrove restoration and usually form a dominant community within a certain period. We characterized the complete mitochondrial genome of this species. The whole mitogenome of L. melanostoma was 16,149 bp in length and its nucleotide composition showed a high AT content of 64.16%. It had 37 genes, including 13 protein-coding genes, 2 ribosomal RNA genes, and 22 transfer RNA genes, and 1 control region between tRNA-Phe and COX3. The A/T composition in the control region was 74.7%, and is much higher than the overall A/T composition of the mitochondrial genomes. The amino acid composition and codon usage of the mitochondrial genomes from seven superfamilies of Littorinimorpha were analyzed, and the results showed that CUU (Leu), GCU (Ala), AUU (Ile), UCU (Ser), UUA (Leu), GUU (Gly), and UUU (Phe) are the commonly used codons. The maximum likelihood phylogenetic tree reconstructed using 62 species of Littorinimorpha presented consistency between the molecular and morphological classifications, which provide a basis to understand the phylogeny and evolution of this order. In the phylogenetic tree, L. melanostoma is located within Littorinoidea and is closely related to L. sinensis, a rock-dwelling species that is widespread in the coastal intertidal zone of China.
Exploring Genetic and Morphological Integrity across Ocean Basins: A Case Study of the Mesopelagic Shrimp Systellaspis debilis (Decapoda: Oplophoridae)
Authors: Shapkina Anna , Kulagin Dmitry , Khaitov Vadim , Lunina Anastasiia , Vereshchaka Alexander
Published: September 2023

Plankton communities often consist of cosmopolitan species with an extensive gene flow between populations. Nevertheless, populations of some plankton species are genetically structured, owing to various barriers such as ocean currents, hydrological fronts, and continents. Drivers that could explain the genetic structures of most mesopelagic species remain unknown on an ocean-basin scale, and our study aims to analyze the genetic and morphological differences between populations of a cosmopolitan mesopelagic shrimp, Systellaspis debilis, from the Southern and Northern Atlantic Ocean, and the Southwest Indian Ocean. We analyzed the ITS-1 and COI markers of 75 specimens and assessed the genetic integrity and within-species variability of these genes. We also coded 32 morphological characteristics in 73 specimens, analyzed their variability, and assessed the correlation between morphological and genetic characteristics using a Redundancy analysis and Mantel test. Systellaspis debilis was genetically cohesive across the whole Atlantic and Southwest Indian Oceans, which is possibly a result of an intensive gene flow through ecological barriers, the resistance of species to hydrological gradients, a purifying selection of mitochondrial genes, etc. In contrast, we found significant morphological differences between populations from different regions, which mirrors morphological diversification and calls for further genomic approaches in order to understand the basis of these variations and uncover potential local adaptations.
Evaluating User Compliance in Mobile Health Apps: Insights from a 90-Day Study Using a Digital Sleep Diary
Authors: Kristbergsdottir Hlín , Schmitz Lisa , Arnardottir Erna Sif , Islind Anna Sigridur
Published: September 2023

Sleep diaries are the gold standard for subjective assessment of sleep variables in clinical practice. Digitization of sleep diaries is needed, as paper versions are prone to human error, memory bias, and difficulties monitoring compliance. Methods: 45 healthy eligible participants (Mage = 50.3 years, range 23–74, 56% female) were asked to use a sleep diary mobile app for 90 consecutive days. Univariate and bivariate analysis was used for group comparison and linear regression for analyzing reporting trends and compliance over time. Results: Overall compliance was high in the first two study months but tended to decrease over time (p < 0.001). Morning and evening diary entries were highly correlated (r = 0.932, p < 0.001) and participants significantly answered on average 4.1 days (95% CI [1.7, 6.6]) more often in the morning (M = 60.2, sd = 22.1) than evening ((M = 56.1, sd = 22.2), p < 0.001). Conclusion: Using a daily diary assessment in a longitudinal sleep study with a sleep diary delivered through a mobile application was feasible, and compliance in this study was satisfactory.
A Collaborative Inference Algorithm in Low-Earth-Orbit Satellite Network for Unmanned Aerial Vehicle
Authors: Xu Zhengqian , Zhang Peiying , Li Chengcheng , Zhu Hailong , Xu Guanjun , Sun Chenhua
Published: September 2023

In recent years, the low-Earth-orbit (LEO) satellite network has achieved considerable development. Moreover, it is necessary to introduce edge computing into LEO networks, which can provide high-quality services, such as worldwide seamless low-delay computation offloading for unmanned aerial vehicles (UAVs) or user terminals and nearby remote-sensing data processing for UAVs or satellites. However, because the computation resource of the satellite is relatively scarce compared to the ground server, it is hard for a single satellite to complete massive deep neural network (DNN) inference tasks in a short time. Consequently, in this paper, we focus on the multi-satellite collaborative inference problem and propose a novel COllaborative INference algorithm for LEO edge computing called COIN-LEO. COIN-LEO manages to split the complete DNN model into several submodels consisting of some consecutive layers and deploy these submodels to several satellites for inference. We innovatively leverage deep reinforcement learning (DRL) to efficiently split the model and use a neural network (NN) to predict the time required for inference tasks of a specific submodel on a specific satellite. By implementing COIN-LEO and evaluating its performance in a highly realistic satellite-network-emulation platform, we find that our COIN-LEO outperforms baseline algorithms in terms of inference throughput, time consumed and network traffic overhead.
Quantum LDPC Codes Based on Cocyclic Block Matrices
Authors: Li Yuan , Guo Ying
Published: September 2023

Motivated by a family of binary cocyclic block matrices over GF(2), we proposed a construction method to gain the stabilizer of long-length quantum error-correction codes (QECCs). Stabilizer quantum codes (SQCs) can be obtained by the different rows of the yielded circulant permutation matrices; hence, the quantum codes have the virtue of a fast construction algorithm. The recursive relation of a block matrix is employed in the proposed approach, so that the generator matrix of quantum cocyclic codes with long length can be constructed easily. Furthermore, the obtained quantum codes have the low-density advantage of there being no 4-cycles in the Tanner graph.
Adaptive MCMC for Bayesian Variable Selection in Generalised Linear Models and Survival Models
Authors: Liang Xitong , Livingstone Samuel , Griffin Jim
Published: September 2023

Developing an efficient computational scheme for high-dimensional Bayesian variable selection in generalised linear models and survival models has always been a challenging problem due to the absence of closed-form solutions to the marginal likelihood. The Reversible Jump Markov Chain Monte Carlo (RJMCMC) approach can be employed to jointly sample models and coefficients, but the effective design of the trans-dimensional jumps of RJMCMC can be challenging, making it hard to implement. Alternatively, the marginal likelihood can be derived conditional on latent variables using a data-augmentation scheme (e.g., Pólya-gamma data augmentation for logistic regression) or using other estimation methods. However, suitable data-augmentation schemes are not available for every generalised linear model and survival model, and estimating the marginal likelihood using a Laplace approximation or a correlated pseudo-marginal method can be computationally expensive. In this paper, three main contributions are presented. Firstly, we present an extended Point-wise implementation of Adaptive Random Neighbourhood Informed proposal (PARNI) to efficiently sample models directly from the marginal posterior distributions of generalised linear models and survival models. Secondly, in light of the recently proposed approximate Laplace approximation, we describe an efficient and accurate estimation method for marginal likelihood that involves adaptive parameters. Additionally, we describe a new method to adapt the algorithmic tuning parameters of the PARNI proposal by replacing Rao-Blackwellised estimates with the combination of a warm-start estimate and the ergodic average. We present numerous numerical results from simulated data and eight high-dimensional genetic mapping data-sets to showcase the efficiency of the novel PARNI proposal compared with the baseline add–delete–swap proposal.
Preliminary Effectiveness of Professional Learning about Disability-Specific Evidence-Based Classroom Practices for Education Support Staff
Authors: Devenish Bethany D. , Mantilla Ana , Bussey Katherine , McGillivray Jane , Rinehart Nicole J.
Published: September 2023

Education support staff work closely with students with disability, yet often receive little training or professional learning in evidence-based practices. This study sought to provide an initial indication of the effectiveness of novel, co-designed, evidence-based online professional learning courses (AllPlay Learn) for education support staff. A total of 323 education support staff working in primary and secondary schools in Victoria, Australia, completed the courses and participated in this study. The results indicated significant improvements in their self-reported knowledge about disability (r = 0.68 and 0.71) and self-efficacy in engaging in inclusive classroom practices (r = 0.62 and 0.62) after taking part in the professional learning course. Analysis of open-ended questions found further support for these gains. These findings provide support for co-designed, evidence-based online professional learning that addresses disability-specific domains of inclusive classroom practices in education.
Development of Lower Computer for Hydraulically Actuated Quadruped Bionic Robots Based on DSP
Authors: Gao Bingwei , Wang Yongkang , Han Wenlong , Xue Shilong
Published: September 2023

Background: Hydraulic quadruped robots have broad application prospects. Control system design is the core content of robot design. However, the micro-controllers used in the past have shortcomings such as long sampling period and simple algorithm. Methods: An electric control system of the layered, distributed structure for hydraulically actuated quadruped robots is designed considering a dog as a bionic model. In order to improve the response time and the steady precision of the system at the same time, a Fuzzy–PID compound control algorithm is put forward in this paper. The hardware and software of the control system are designed. Results: The lower computer’s control system for hydraulically actuated quadruped robots is developed using TMS320F28335 in series of DSP2000 as the core processor. Outside control circuit expands some external chips, such as AD7606, AD5754R, and PCA82C250, and a peripheral interface circuit is designed. Taking full advantage of the efficient processing power of the chip and the rich on-chip resources, the hardware circuit is simpler and reliable, and the software is also easy to implement. It is verified that the control system is rational and effective using experiments. Conclusions: The experimental results show that the control system designed in this paper is reasonable and can effectively control the joints of the quadruped robot. It has strong scalability and can meet the basic requirements of the autonomous mobile robot control system.
The Potential of Vapor Compression Heat Pumps Supplying Process Heat between 100 and 200 °C in the Chemical Industry
Authors: Vieren Elias , Demeester Toon , Beyne Wim , Magni Chiara , Abedini Hamed , Arpagaus Cordin , Bertsch Stefan , Arteconi Alessia , De Paepe Michel , Lecompte Steven
Published: September 2023

The supply of process heat in the chemical industry is dominated by fossil fuel combustion. Heat with temperatures up to 200 °C could, however, be supplied by vapor compression heat pumps (VCHPs), allowing for efficient electrification. However, there are still several barriers that need to be overcome before they can be widely implemented. In this work VCHPs are thermodynamically compared to heat-driven heat pumps and heat transformers, exploiting the potential of VCHPs. Moreover, steam production, distillation and drying are found to be of primary interest within the chemical industry, and potential integration points are presented and discussed for these applications. Finally, a financial analysis is performed based on a steam production and a superheated steam drying case study. The analysis calculates the levelized cost of heat (LCOH) of a VCHP, heat transformer, natural gas boiler and electric boiler. Furthermore, a sensitivity analysis of the LCOH to the annual operating hours, carbon pricing and waste heat availability is presented. Generally, when no emissions trading scheme (ETS) is applied, both the VCHP and a combination of a heat transformer with auxiliary natural gas boiler appeared as the most optimal solutions, depending on the energy prices. Due to the limited utilization of waste heat by the heat transformer, an auxiliary natural gas or electric boiler is essential to fully meet the required heating load. When an ETS is being applied the VCHP generally appeared to be most financially attractive technology for both the case studies.