bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the hydraulic characteristics of flushing fluid when gas enters wells drilled from semi-submersible drilling rigs
Authors:   Department of Oil and Gas Engineering of Azerbaijan State Oil and Industry University, Ibrahimov Rafiq , Bahshaliyeva Shirin ,   Department of Oil and Gas Engineering of Azerbaijan State Oil and Industry University, Ibrahimov Zaur ,   Bаker Hughes, Azerbaijan
Published: June 2022

The article considers how in recent years the study of hydraulics and hydrodynamics have been successfully used in the qualitative analysis of complications arising during the drilling of wells. One of the main factors determining the success of well drilling is hydrodynamic pressure. Also a boundary layer forms both on the wall of the casings and on the walls of the well has important means. One potential complication is the appearance of gas when a well is drilled from a semi-submersible drilling rig. The article deals with issues of clarifying the nature and eliminating gas, as well as preventive measures and their consequences. However, in order to take a final decision it is necessary to analyse the nature of the pressure change at the blowout preventer on a semi-submersible drilling rig. A number of works have been devoted to determining hydraulic pressure and hydraulic resistance in the circulation system of wells, on the basis of both stationary and non-stationary processes. Gas was observed in well no. 28 of the Sangachal-Sea field (Caspian Sea, Azerbaijan) at a depth of 3819 m and with a specific gravity of the flushing fluid of 2.25–2.27 g/cm3. When the blowout preventer was closed, the pressure increased to 10 MPa for 2–3 hours, before decreasing to 2.5 MPa and stabilising. The conclusion from this is that if the flow rate, the angle of deviation of the installation and contact time of the surfaces are constant, the influence of the flushing fluid decreases as the pressure drop increases. As the fluid filtration rate increases, the friction force between the drill pipe and the borehole wall increases. The friction force between the surfaces of the column and the filter cake is inversely proportional to the fillet velocity.
Opracowanie modelu obliczania emisji GHG w cyklu życia biowodoru produkowanego w technologii (bio)metan do wodoru i węgla
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Rogowska Delfina
Published: June 2022

Mając na względzie globalny trend poszukiwania paliw przyjaznych dla środowiska, w szczególności paliw niskoemisyjnych, zwrócono uwagę na technologię konwersji metanu do wodoru. W artykule przedstawiono sposób obliczania emisji GHG w cyklu życia biowodoru produkowanego poprzez pirolizę (bio)metanu. Technologia ta wydaje się przyszłościowa ze względu na fakt, że pozwala uzyskać zeroemisyjne paliwo. Podczas tego procesu otrzymuje się czysty wodór i stały węgiel. Węgiel może być wykorzystany przez wiele różnych gałęzi przemysłu, niekoniecznie jako paliwo. Zgodnie z dyrektywą 2018/2001 biopaliwo musi wykazać spełnienie założonego progu redukcji emisji GHG. Dlatego jest niezmiernie ważne, aby oceniać każdą nową technologię pod kątem emisyjności produktu. Obliczenia zostały przeprowadzone zgodnie z metodyką ustanowioną w dyrektywie 2018/2001, a w szczególności zgodnie z dokumentacją systemu KZR INiG. Do przeprowadzenia oceny przyjęto następujące założenia: model jednostki przetwórczej oraz dane wejściowe do tego etapu zaczerpnięto z danych literaturowych; przyjęto, że surowiec stanowi biometan produkowany z bioodpadów; obliczenia dla etapu pirolizy przeprowadzono jako obliczenia wartości rzeczywistych, natomiast dla pozostałych etapów cyklu życia biowodoru przyjęto wartości standardowe z dyrektywy 2018/2001. Badania wykazały, że wodór może osiągnąć poziom 69% redukcji emisji GHG w porównaniu z paliwem kopalnym (jako odpowiednik paliwa kopalnego wykorzystano wartość 94 gCO2eq/MJ). Jest to niewiele więcej niż wymagany próg 65%. Oznacza to, że podczas prac nad rozwojem tej technologii aspekty emisji GHG muszą być mocno brane pod uwagę.
Pomen kompetenc za zasedbo delovnih mest na terciarni ravni izobrazbe na kadrovskem področju
Authors:   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia, Andonov Adrijana , Žnidaršič Anja ,   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia, Novak Vesna ,   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia
Published: June 2022

This paper discusses the importance of competences for filling vacancies at the tertiary level of education in the field of HR. We analysed the expected competences for the human resources profile with the required tertiary education, which were listed in employers' job advertisements from 2017 to 2019 on the portal of the Slovenian Employment Service. The list of competences was self-assessed by the final year students of the HR education systems at the University of Maribor, Faculty of Organizational Sciences in order to find out to what extent they actually developed the competences. We have found that employers value the work experience, knowledge and soft skills that future recruiters need to have. This gives graduates who have also gained knowledge and experience in informal ways during their studies an advantage. However, student selfassessments show that most students are still unaware of the importance of acquiring additional competences that would set them apart from their competitors and, as a result, facilitate the transition from education to employment.
Vpliv pandemije Covid-19 na digitalno preobrazbo mikro, malih in srednje velikih podjetij: Vidik šestih slovenskih podjetij
Authors:   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia, Marolt Marjeta , Kljajić Boštnar Mirjana ,   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia, Lenart Gregor ,   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia, Gašperlin Blaž ,   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia, Vidmar Doroteja ,   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia, Pucihar Andreja ,   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia
Published: June 2022

The COVID-19 pandemic has changed the way we live and businesses operate. Various industries and sectors were affected, which had a strong impact on economic growth. Micro, small, and medium sized enterprises (SMEs) were not exception. While SMEs in comparison to large enterprises lag behind in digital transformation, but are important part of worlds economy, we are interested in their digital transformation pushed forward by the COVID-19 pandemic. In order to gain a comprehensive view of the events related to the digital transformation of companies in the last two years, we conducted interviews with six Slovenian SMEs. Based on the collected data, we present preliminary findings and discuss opportunities for further research in this field.
Izzivi moderne organizacije v WUCA svetu
Authors:   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia, Meško Maja , Roblek Vasja ,   Faculty of Organization Studies, Novo mesto, Slovenia
Published: June 2022

The dynamic and unstable environment and the VUCA world, which represents the volatility, uncertainty, complexity and ambiguity of the times in which we live, have brought new challenges to organizations. In this article, we answer the research question How can business leaders in a company respond to the challenges posed by the VUCA world in the business environment? The answer must be sought within the determinants of future organizational changes or the so-called agile organization, which can quickly adapt to the VUCA world. To ensure an innovative, dynamic and agile business environment, VUCA also needs to create a new management model that pays attention to the development of HRM 4.0.
Communication Between Students and Teachers in a Distance Learning Environment During the COVID-19 Pandemic in Serbia
Authors:   Academy of Vocational Studies South Serbia, Department of Business Studies Blace, Serbia, Mihajlov Nenad , Novakovic Jasmina ,   Belgrade Business and Arts Academy of Applied Studies, Serbia, Mihajlov Snezana ,   Academy of Vocational Studies South Serbia, Department of Business Studies Blace, Serbia, Markovic Suzana ,   Belgrade Business and Arts Academy of Applied Studies, Serbia
Published: June 2022

The COVID-19 pandemic affected the work of educational institutions, which had to adapt to new circumstances. The authors investigated the impact of online learning on student-teacher communication at the Department of Business Studies in Blace in Serbia. The aim of the authors is to analyze how online learning affects the communication between students and teachers and investigate the level of productivity and creativity of students in the new environment. The research study was conducted through a structured online survey using a random sampling technique. In the traditional way of organizing classes, face-to-face classes, students are more motivated and engaged in learning, and deprived of a sense of social isolation. The results of the research prove that students need more frequent interactive dialogue with teachers through formal and informal communication channels. Also, the authors will suggest possible ways to improve the productivity and creativity of students in the online environment.
Trajnostni izzivi investiranja v samooskrbne sončne elektrarne
Authors:   Biotechnical Centre Naklo, Naklo, Slovenia, Papler Dragp
Published: June 2022

Slovenia has only achieved its commitment of 25% share of renewables in final energy consumption by 2020, with a target of 27% by 2030 and 32% for the EU-27, by purchasing additional emission allowances. During the 20-year period of solar power plant construction in Slovenia, feed-in tariff subsidy models have been developed for the electricity generated from solar power plants, in the form of guaranteed feed-in or operating support, which have been very profitable in the past. The disbursement of subsidies for renewable electricity has exceeded the planned volumes. With the changed policy of subsidy reductions, investments started to decrease. After 2017, self-consumption and self-supply of electricity started to be promoted and had good promotional support. The main focus of this section is an economic analysis of the viability of investing in the construction of a solar power plant under normal and changed conditions, in terms of the potential risks and additional benefits of using electricity from a self-sustaining solar power plant. Economic indicators of investment performance from the investor's point of view, such as payback periods, net present value, internal rates of return under normal conditions and in the case of risks and uncertainties, and taking into account the additional social benefits of the average price of emission allowances were analysed for the Cost Benefit Analysis.
SME’s Business Model Sustainability in Croatia
Authors:   University of Zagreb, Faculty of Economics and Business, Croatia, Pavković Anita
Published: June 2022

Small and Medium sized Enterprises (SMEs) are important part of each economy. The paper studies the importance of SMEs in national economy, participation of different economic activities in SMEs business models, management actions in finding the answers to particular strategic questions in the process of creating an efficient and sustainable business models for SMEs. For creating a systemic efficiency measure, hybrid finance, liquidity, profitability and similar indicators are used for measuring efficiency of SMEs in Croatia. Analysis has pointed out the main problems and limitations, and finally indicates the necessity of improvement of SMEs business policies in Croatia. SMEs are exposed to different challenges, but analysis concluded different scope and manner of exposure across sectors, especially in the context of COVID-19 consequences. Paper is consisted of several parts, after introduction literature review presents significance SMEs in national economies, followed by chosen data, indicators and methodology, results and interpretations, concluding remarks and proposal for more efficient SMEs business models.
Mnogotero inteligenten pristop k managementu sestankov: analiza izkušenj s sestankov študentov managementa
Authors:   University of Ljubljana, School of economics and business, Ljubljana, Slovenia, Peterlin Judita , Dimovski Vlado ,   University of Ljubljana, School of economics and business, Ljubljana, Slovenia, Starc Andrej ,   University of Ljubljana, Faculty of Health Sciences, Ljubljana, Slovenia
Published: June 2022

The article discusses meeting management with an aim to make practical recommendations for improving our day-today meetings. Regardless of the organization in which we work, most of us have already experienced meetings, which show a lack of preparation or inadequate management of the process of the meeting or the inappropriate implementation of decisions made at the meeting. In the theoretical part, based on the literature in the field of meeting management, we give an overview of modern research and classic studies. In the empirical part, we present the obtained data of good and bad meetings experienced by students of management in the course, which takes place in the academic year 2021/22 at the University of Ljubljana and is attended by 88 students of various fields. The implications of the paper are in the direction of providing recommendations for our future meetings.
Mnenje študentov zdravstvene nege in fizioterapije na Fakulteti za zdravstvo Angele Boškin o izobraževanju na daljavo v času epidemije
Authors:   Angela Boškin Faculty of Health Care, Jesenice, Slovenia, Pivač Sanela , Smodiš Marta ,   Angela Boškin Faculty of Health Care, Jesenice, Slovenia, Kalender Smajlović Sedina ,   Angela Boškin Faculty of Health Care, Jesenice, Slovenia
Published: June 2022

Background: Working methods in education changed during the SARS-CoV-2 (COVID-19) pandemic, bringing new challenges to managers in education. Methods: Nonexperimental design of quantitative research was employed. Data was collected using an online survey. The research included 195 first-cycle nursing and physiotherapy students. Data was analyzed using SPSS software, v. 20.0. Results: Distance learning was favored more by women (M=4.0, SD = 1.3) compared to men (M = 3.5; SD = 1.4), more by full-time students (M = 4.1, SD = 1.3) compared to part-time students (M = 3.7, SD = 1.4), more by students with a previous secondary education nursing degree (M = 4.0; SD = 1.2). Discussion: During the pandemic, distance learning was organized, requiring the management to adapt quickly and make changes according to available IT solutions.
Z mladimi gospodarji do večje dodane vrednosti na slovenskih kmetijah
Authors:   Biotechnical Centre Naklo, Naklo, Slovenia, Pogačnik Marijan , Vidic Franc ,   VIZART Anže Vidic s. p., Škofja Loka,Slovenia
Published: June 2022

Agriculture, and with it the food chain as a whole, is facing major technological and environmental challenges to provide enough affordable and safe food for the population. European/Slovenian agricultural policy pays a lot of attention to young farm managers who will be able to keep up with the changes and achieve the objectives set. The proportion of young farmers is 11% in the EU, but only 6% in Slovenia, so a systemic approach will be needed to increase this proportion. This means that this generation will need to be given the right combination of training, access to affordable credits, incentives in the integration of the whole food chain and other measures to make them take over farms. While current financial investments (Rural Development Programme sub-measure 6.1) encourage young farmers to take up farming and achieve a higher added value, surveys show that young people expect support in other areas, and they also expect to be given more value in the provision of sufficiently affordable and safe food.
Challenges and Perspectives for Remote Work
Authors: Radulovic Jovana , Deretic Nemanja , Vujanovic Nikola , Matic Rade , Djurica Nina
Published: June 2022

The world has witnessed a historic shift in the labor market in 2020 and 2021 due to the COVID-19 pandemic. While some companies used to offer the possibility of working from home as an advantage, now it has become the norm for most companies. By 2025, it is estimated that 70% of the workforce will work remotely at least five days a month. Although 2020 can be considered the year of remote working, this is just the beginning because we see that the trend continues in 2022. Even in new circumstances such as Health Crisis, all variations of the distance jobs and hybrid working models were not just the outcomes of the global business conspiracy but true working model tools which have been developed since evolutional decades of information technologies. The methods used in the paper are literature review, data analysis, descriptive statistics and comparative method. The results presented in the paper showed that remote workers will become the new norm in the business world.
Ravnanje z odpadki iz zdravstva v času pandemije Covid-19: sistematični pregled literature
Authors:   University of Maribor, Faculty of Health Sciences, Maribor, Slovenija, Rozman Urška , Vöröš Gaal Anja ,   University of Maribor, Faculty of Health Sciences, Maribor, Slovenija, Kmetec Sergej ,   University of Maribor, Faculty of Health Sciences, Maribor, Slovenija, Turk Šostar Sonja ,   University of Maribor, Faculty of Health Sciences, Maribor, Slovenija
Published: June 2022

The covid-19 pandemic has brought drastic changes in the production and consumption of health care waste, with special attention being paid to infectious waste, and the fact that the use of disposable materials has increased. The purpose of the study was to determine how healthcare waste is handled during the covid-19 pandemic. A systematic literature review was performed in the Cinahl, Medline and PubMed databases, according to the PRISMA guidelines. 20 studies were included in the final review and analysis of the literature. New best approaches, models and tools for healthcare waste management during the covid-19 pandemic have been developed and adopted in various countries around the world. Incineration has proven to be the best method for healthcare waste management. Awareness of the population about the potential danger of health waste has improved, which has led to stricter compliance with existing legislation. Guidelines for hospital waste management have also been prepared by the World Health Organization.
In Searching for Greener Economic Outcomes; Identification of Factors Influencing Green GDP
Authors:   Juraj Dobrila University of Pula, Faculty of Economics and Tourism »Dr. Mijo Mirković«, Croatia, Tomić Daniel , Stjepanović Saša ,   Juraj Dobrila University of Pula, Faculty of Economics and Tourism »Dr. Mijo Mirković«, Croatia
Published: June 2022

The recent slowdown in CO2 emission is largely result of three factors; weaker economic growth due to global crisis aftermaths, continual improvements in energy intensity and shifts to lower carbon energy thus higher carbon footprint of energy. Various approaches such as IPAT and/or KAYA identities are used to analyze the input factors of CO2 emissions, playing a crucial role in the creation of distinct emission forecasts. In addition, Environmental Kuznets curve hypothesizes a positive relation between income and environmental quality. Arguments that came out of the controversies regarding the validity of these identities provided relevant theoretical discussion for the claim that economic growth can be achieved on sustainable and green foundations. Based on a scarce number of papers related to Green GDP – energy intensity – carbon footprint nexus, we want to analyze how major environmental factors (GDP per capita, emissions of CO2, energy consumption per GDP and carbon intensity per unit energy) affect the so-called green growth perspective. Long-run empirical assessment is founded on a panel cointegration modelling for the period 2007-2019 for the sample of 37 European countries. The results confront some established environmental stances, confirming the negative effect of GDP per capita and CO2 emissions, and a positive effect of both energy intensity and carbon footprint on the green growth developments.
Model ocenjevanja učinkov organizacijskih sprememb
Authors:   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia, Urh Benjamin , Kern Tomaž ,   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia, Krhač Andrašec Eva ,   University of Maribor, Faculty of Organizational Sciences, Kranj, Slovenia
Published: June 2022

In this paper, we discuss quantitative and qualitative ways of assessing the effectiveness and efficiency of organizational changes. In organizational systems, they are increasingly faced with the need for such assessments due to adaptation of operations to new conditions. The assessment of organizational changes is based on comparing efficiency and effectiveness indicators before and after the change. However, the problem often arises from the lack of available data to carry out the assessment. In the first part of the paper, we presented possible ways of assessing organizational changes based on the available literature. Due to the problems and shortcomings of individual methods, we have subsequently developed a combined model for assessing the effects of organizational changes. We used the model in the case of a large business system. Based on the study results, the advantages of the presented model are identified. The model upgrades the existing assessment methods and enables a more comprehensive assessment of the effects of organizational changes.
Online Consumer Behavior in Serbia During the Crisis Caused by Covid- 19
Authors:   Belgrade Business and Arts Academy of Applied Studies, Belgrade, Serbia, Zekavica Ana , Vukmirović Jovanka ,   University of Belgrade, Faculty of Organizational Sciences, Belgrade; Serbia, Vukmirović Aleksandra ,   Belgrade Business and Arts Academy of Applied Studies, Belgrade, Serbia, Branković Milica ,   Belgrade Business and Arts Academy of Applied Studies, Belgrade, Serbia
Published: June 2022

In parallel with the development of the digital market, a new generation of consumers has emerged. The digital market has become an integral part of the lives of modern consumers and it is simply difficult to imagine middle and younger consumers not being present in the digital market on a daily basis to gather information important for purchasing decisions and / or purchasing. There is a growing need for new knowledge, theories and models that indicate consumer behavior on the Internet, due to the evolution of online shopping, which is becoming a vital aspect of customer relations and the creation of marketing strategies. The corona virus pandemic that occurred in March 2020 is not just a health crisis, it has changed the way people around the world live. This paper examines whether there are changes in the level of online consumption and changes in consumer behavior in Serbia in general.
Trajnostni razvoj in politična pravičnosti
Authors: Žnidarič Davorin
Published: June 2022

Due to the negative effects of spatial development, the current social and environmental conditions require unified concepts of solutions aimed at reducing disparities, poverty and increasing various forms of justice. Sustainable development, as the predominant environmental discourse of modern times, has been facing the problem of implementing fundamental guidelines in practice since its establishment in the mid-1980s. The balance of socio-economic, economic and especially environmental indicators, which is still perceived as an unrealizable utopia of modern society due to the inconsistent conception of the concept and action from the position of power, influence of capital and interests of "strong" countries, through narrow economic and political interests. In the prevailing, neoliberal global order, it represents an increase in the influence of partial interests (capital, influential countries, elites) on decision-making (including individual economic and political decisions of governments), departure from original, otherwise good intentions and impulses, changes in social behavior. There are several reasons for the mentioned stagnation and unsuccessful activation of changes in space, and especially global inactivity. The fundamental problem is the lack of political justice, which is a prerequisite for ensuring all other justice (environmental, ecological or social), which leads to reducing equality and differences in society and limiting and ensuring the rights and duties of the individual or the interests of society as a whole.
Psychobiografia naukowa: od metody badawczej do tekstu
Authors: Całek Anita
Published: June 2022

The article suggests a reflection on biography understood as a textual representation of life passing by empirically. The process of creating such a biography, functioning (often during the life of its writer) as a substitute of his/her actual presence in the world, requires high methodological awareness and knowledge of rules that help to transform life into a text. A tool such as psychobiographic-literary method that are described in the second part of the article, transforms the assumptions presented at the beginning into specific research procedures in a very practical way.
Badania biograficzne wśród artystów plastyków – refleksja badacza
Authors: Lasocińska Kamila
Published: June 2022

In her article, the Author presents her reflections and deliberations concerning biographic research, which were the aftermath of interviews that she had carried out among artists. She shares her suggestions on the narrative interviews and the limitations that may appear in the process of reconstructing a biography. She also draws attention to the role of art in these biographies, treating it as an important aspect of life of the studied individuals, but also as a significant element of a reconstructed biography.
Transport and Logistics System of Turkmenistan
Authors: Pokrovskaya Oksana , Eldashov Zyyarat , Marchenko Maksim , Sheverdova Mariya
Published: June 2022

Purpose: To conduct an analytical study of the current state of Turkmenistan transport and logistics system, taking into account the geopolitical situation, including the questions of the development of logistics infrastructure and international transport corridors and ongoing large-scale transport-logistics projects. Methods: The method of analytical review of the state of transport and logistics system of the Republic of Turkmenistan is applied. Results: The characterization of the development of transport modes, of established trade-economic and transport links is given. The analysis of existing logistics infrastructure is carried out. The key features of Turkmenistan transport and logistics system are established. Promising target development tracks are formulated. Practical significance: An analytical review of the current state, trends and prospects for the development of Turkmenistan transport and logistics system has been carried out. It has been established that Turkmen transport and logistics system works with cargo flows through almost all transport modes. The country develops modern logistics tools, building modern competitive transport macrostructure, which includes the system of international transport corridors and multimodal type logistics centers, and pursues policy of open transport-logistic space and integration. Based on the study results, the key distinctive features of transport-logistic system existing image were formulated, SWOT analysis of transport-logistics system features was performed, as well as promising tracks of the system development were defined.
Relações de produção científica e tecnológica nas redes de pesquisa
Authors: Magalhães Rafaela Cajado , Buarque Brenno , Câmara Samuel Façanha , Tahim Elda Fontinele , Carvalho Hermano José Batista de
Published: June 2022

Esta pesquisa tem como objetivo analisar as interações dos atores da Rede Nordeste de Biotecnologia (RENORBIO), com base no estudo de seu perfil de produção científica e tecnológica. A RENORBIO atua como pioneira na região Nordeste, desde a criação do Programa de Pós-Graduação em Biotecnologia. A coleta de dados consistiu na busca por informações acerca das produções bibliográficas, produções técnicas (patentes) e registros de spin-offs oriundas das pesquisas desenvolvidas nos 13 pontos focais, as coordenações locais abrigadas nas principais instituições de ensino e pesquisa credenciadas na Rede, que abrigam em torno de 30 outras instituições associadas à RENORBIO, com o intuito de mapear as interações dos atores da rede. Para análise dos resultados, os dados foram tratados no software UCINET. O software contribuiu de forma essencial no estudo das interações dos agentes da Rede, auxiliando na caracterização de interações técnicas e acadêmicas da RENORBIO, tendo como base a análise de suas Transferências de Tecnologias, permitindo, assim, traçar o perfil desta rede à luz da Teoria de Redes Sociais. Identificou-se que a Rede apresenta uma topologia que poderíamos chamar de “satelizada”, onde uma rede central atrai e influencia nas relações de pesquisa entre os atores das demais redes, que gravitam em torno desta, formando uma força de atração institucional entre esses atores. Trata-se de uma rede heterogênea, caracterizada pela baixa densidade e amplo fluxo de interações diversas dos seus atores. Além disso, exibe uma importante representatividade na produção de inovações para a região Nordeste, podendo impactar de forma direta ou indireta na condição socioeconômica desta região e atuar na solução de problemáticas nacionais, na área da biotecnologia.
A moderação do mimetismo no desempenho de ecoinovações
Authors: Silva José Jaconias , Cirani Claudia Brito Silva , Dias Helison Bertoli Alves , Lima Ana Maria de
Published: June 2022

Este estudo investigou não apenas a relação entre a ecoinovação e o desempenho ambiental e financeiro, mas também o papel moderador da pressão mimética institucional nessa relação. Coletamos e analisamos 175 casos de empresas brasileiras que se tornaram verdes, usando modelagem de equações estruturais. Os principais resultados apontam para (i) uma relação positiva entre a ecoinovação e o desempenho ambiental; (ii) a relação entre ecoinovação e desempenho financeiro não ocorre de forma direta, mas indireta, devido ao desempenho ambiental; e (iii) a pressão mimética atenua a influência da ecoinovação no desempenho ambiental e financeiro. Esse achado ainda não havia sido verificado na literatura sobre inovação, uma contribuição inédita deste trabalho. Portanto, os gerentes de negócios podem usar os resultados para implementar sistemas de gestão da inovação sob perspectivas ecoinovadoras para produzir bens com menor impacto ambiental.
Fallen: Generation, Postlapsarian Verticality + the Black Chthonic
Authors: Cooper Cecilio M.
Published: June 2022

This essay theorizes how blackness and fallenness inflect postlapsarian verticality.
Brown and Queer Futurities in José Esteban Muñoz’s Sense of Brown
Authors: Stekl Míša
Published: June 2022

A review of Sense of Brown by Jose Esteban Munoz
Drug resistance in metastatic castration-resistant prostate cancer: an update on the status quo
Authors: Yehya Amani , Ghamlouche Fatima , Zahwe Amin , Zeid Yousef , Wakimian Kevork , Mukherji Deborah , Abou-Kheir Wassim
Published: June 2022

Prostate cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men globally. Despite improvements in the diagnosis and treatment of PCa, a significant proportion of patients with high-risk localized disease and all patients with advanced disease at diagnosis will experience progression to metastatic castration-resistant prostate cancer (mCRPC). Multiple drugs are now approved as the standard of care treatments for patients with mCRPC that have been shown to prolong survival. Although the majority of patients will respond initially, primary and secondary resistance to these therapies make mCRPC an incurable disease. Several molecular mechanisms underlie the development of mCRPC, with the androgen receptor (AR) axis being the main driver as well as the key drug target. Understanding resistance mechanisms is crucial for discovering novel therapeutic strategies to delay or reverse the progression of the disease. In this review, we address the diverse mechanisms of drug resistance in mCRPC. In addition, we shed light on emerging targeted therapies currently being tested in clinical trials with promising potential to overcome mCRPC-drug resistance.
Therapeutics to harness the immune microenvironment in multiple myeloma
Authors: Ignatz-Hoover James J. , Driscoll James J.
Published: June 2022

Multiple myeloma (MM) remains an incurable, genetically heterogeneous disease characterized by the uncontrolled proliferation of transformed plasma cells nurtured within a permissive bone marrow (BM) microenvironment. Current therapies leverage the unique biology of MM cells and target the immune microenvironment that drives tumor growth and facilitates immune evasion. Proteasome inhibitors and immunomodulatory drugs were initially introduced to complement and have now supplanted cytotoxic chemotherapy as frontline anti-myeloma agents. Recently, monoclonal antibodies, bispecific antibodies, and chimeric antigen receptor T cells were developed to revamp the immune system to overcome immune suppression and improve patient responses. While current MM therapies have markedly extended patient survival, acquired drug resistance inevitably emerges and drives disease progression. The logical progression for the next generation of MM therapies would be to design and validate agents that prevent and/or overcome acquired resistance to immunotherapies. The complex BM microenvironment promotes resistance to both current anti-myeloma agents and emerging immunotherapies. Myeloma cells are intertwined with a complex BM immune microenvironment that contributes to the development of adaptive drug resistance. Here, we describe recently FDA-approved and investigational anti-myeloma agents that directly or indirectly target the BM microenvironment to prevent or overcome drug resistance. Synergistic effects of anti-myeloma agents may foster the development of rationally-designed drug cocktails that prevent BM-mediated resistance to immunotherapies.
Base excision repair accessory factors in senescence avoidance and resistance to treatments
Authors: Vickridge Elise , Faraco Camila C. F. , Nepveu Alain
Published: June 2022

Cancer cells, in which the RAS and PI3K pathways are activated, produce high levels of reactive oxygen species (ROS), which cause oxidative DNA damage and ultimately cellular senescence. This process has been documented in tissue culture, mouse models, and human pre-cancerous lesions. In this context, cellular senescence functions as a tumour suppressor mechanism. Some rare cancer cells, however, manage to adapt to avoid senescence and continue to proliferate. One well-documented mode of adaptation involves increased production of antioxidants often associated with inactivation of the KEAP1 tumour suppressor gene and the resulting upregulation of the NRF2 transcription factor. In this review, we detail an alternative mode of adaptation to oxidative DNA damage induced by ROS: the increased activity of the base excision repair (BER) pathway, achieved through the enhanced expression of BER enzymes and DNA repair accessory factors. These proteins, exemplified here by the CUT domain proteins CUX1, CUX2, and SATB1, stimulate the activity of BER enzymes. The ensued accelerated repair of oxidative DNA damage enables cancer cells to avoid senescence despite high ROS levels. As a by-product of this adaptation, these cancer cells exhibit increased resistance to genotoxic treatments including ionizing radiation, temozolomide, and cisplatin. Moreover, considering the intrinsic error rate associated with DNA repair and translesion synthesis, the elevated number of oxidative DNA lesions caused by high ROS leads to the accumulation of mutations in the cancer cell population, thereby contributing to tumour heterogeneity and eventually to the acquisition of resistance, a major obstacle to clinical treatment.
A breakthrough in 2-indolylmethanol-involved organocatalytic asymmetric reactions
Authors: Tan Wei , Shi Feng
Published: June 2022

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Bentuk-Bentuk Etika Bermedia Sosial Generasi Milenial
Authors: Hapsari Wijayanti Sri , Sihotang Kasdin , Emmily Dirgantara Vanessa , Maytriyanti
Published: June 2022

This study aims to reveal and identify forms of social media etiquette for the millennial generation in Jakarta. Participants of this study were 268 students at a private university in Jakarta. The social media observed were Facebook, Instagram, WhatsApp, and Line. From the results of distributing online questionnaires, online interviews, documentation, and observations in the lecture and student organizations, it was found that the language used on social media between lecturers and students was formal and informal Indonesian. The language used on social media between students and peers is Indonesian and English, mixed with alay (slang). Social media etiquette includes not offending others, rereading messages before being sent, choosing the right time, choosing polite words for permitting, saying greetings, saying thanks, introducing him/herself, and not interrupting the talk. Nevertheless, etiquette violations are found in using impolite or sarcastic words.
Estrategias de marketing digital para la empresa Alpecorp S.A.
Authors:   , Espinoza Espinoza Lisset Yadira , Jayo Escobedo Alejandro Miguel , Cusi Espinoza Leao Alexis
Published: June 2022

La finalidad de esta representación de negocio es la ejecución del marketing digital en la empresa Alpecorp S.A. donde se va abrir estrategias para atraer clientes potenciales, aumentar las ventas, dar imagen a la marca a través del social media. El marketing digital es una de las estrategias más transcendentales en la coyuntura, y que toda empresa debe adaptarse en estos tiempos de confinamiento, para facilitar las compras a través de los e-commerce. Este sistema de comercialización aplicado a los medios digitales es vital para la elaboración de estrategias que ayuden a plasmar los objetivos de la empresa. Gracias a este medio podemos crear campañas publicitarias por redes sociales, segmentando de una manera más determinada nuestro público objetivo, así obtener datos de nuestros clientes para próximas campañas futuras y mejorar en algunos aspectos. Según Núñez (2020) ayudará extender la prontitud de comprensión y estudio del mercado, y por tanto fortalecer la planificación, consumación y diagnóstico de los técnicos de programación estratégica de la empresa en corto, medio o largo plazo. En el capítulo I, hablamos sobre el análisis del entorno mediante el PESTEL, como también el análisis del entorno específico donde desarrollamos las 5 fuerzas de Porter identificando los puntos internos, externos del mercado y como ayudaría o perjudicaría a la empresa desde el 2021 hasta el 2026 según las informaciones. En el capítulo II, analizamos la misión y visión de la empresa como sus objetivos, también desarrollamos las estrategias genéricas y de entrada y puntuamos las ventajas comparativas y competitivas. En el capítulo III, nos planteamos el objetivo de la investigación, donde realizamos una entrevista y encuesta para obtener información sobre los clientes para la puesta en marcha del marketing digital en la empresa.
Rotación del personal y productividad de los asesores comerciales de una institución microfinanciera, sede Villa El Salvador (Lima-Perú), 2021
Authors:   , Sanchez Rodas Janeth , Zavaleta Cardenas Melissa Allison
Published: June 2022

La finalidad del estudio fue analizar la relación que existe entre rotación del personal y productividad de los asesores comerciales de una institución microfinanciera, sede Villa el Salvador (Lima-Perú), 2021. Su enfoque fue cuantitativo, no experimental, con un tipo de corte transversal y un alcance descriptivo correlacional. La población y muestra estuvo integrado por 81 colaboradores del área comercial de una institución microfinanciera, sede Villa el Salvador. El coeficiente Alfa de Cronbach obtuvo un resultado para la variable rotación de personal de “0,875” y para la variable productividad de “0,886”. Los resultados de la estadística inferencial señalaron una correlación positiva moderada con un Rho de Spearman “0,822”, con una significancia de p = “0,000” <0.05. Se concluyó que, deben gestionar la rotación de personal para no perjudicar la productividad., corroborado por Salazar (2019), Ramos (2018) y Landa (2019).
Conocimientos y actitudes de los estudiantes de Estomatología de la Universidad Científica del Sur sobre la atención de pacientes que reciben terapia antitrombótica
Authors:   , Velarde Gomez Maria Pia
Published: June 2022

El objetivo de este estudio fue determinar el nivel de conocimientos y actitudes sobre la atención de pacientes que reciben terapia antitrombótica entre los estudiantes de pre y postgrados de Estomatología. Participaron 134 estudiantes de la Universidad Científica del Sur durante el año 2021. Para la evaluación de la variable nivel de conocimientos, se hizo uso del cuestionario “Nivel de conocimiento sobre atención estomatológica de pacientes con terapia antitrombótica en estudiantes de odontología de tres universidades peruanas”, evaluado y validado por profesionales competentes en la UNMSM, la cuál está compuesta por 15 preguntas de opción múltiple, con 3 dimensiones (antes, durante y después de un procedimiento odontológico), las cuales fueron calificadas como bajo, regular y alto, según la escala que fue establecida en el estudio. En los resultados, se observó que pregrado predomino en un nivel bajo con un 50.68%, en un nivel de conocimientos general sobre el manejo estomatológico de pacientes que reciben terapia antitrombótica, mientras que postgrado obtuvo un 60.93%. Con los resultados mencionados anteriormente, podemos llegar a la conclusión que existe una deficiencia de conocimientos y actitudes sobre el manejo estomatológico de pacientes que reciben terapia antitrombótica, por parte de los alumnos en formación y alumnos ya graduados que continúan sus estudios con una especialidad. Con un nivel de conocimientos deficiente sobre el tema, y falta del manejo del mismo, podría causar fatalidades en la práctica privada.
Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle damaging resistance exercise in young and older adults – The TAKEOVER study
Authors: Lithgow Hannah , Johnston Lynsey , Ho Frederick K , Celis-Morales Carlos , Cobley James , Raastad Truls , Hunter Angus M , Lees Jennifer S , Mark Patrick B , Quinn Terry J , Gray Stuart
Published: June 2022

Background: Regular participation in resistance exercise is known to have broad ranging health benefits and for this reason is prominent in the current physical activity guidelines. Recovery after such exercise is important for several populations across the age range and nutritional strategies to enhance recovery and modulate post-exercise physiological processes are widely studied, yet effective strategies remain elusive. Vitamin K2 supplementation has emerged as a potential candidate and the aim of the current study, therefore, is to test the hypothesis that vitamin K2 supplementation can accelerate recovery, via modulation of the underlying physiological processes, following a bout of resistance exercise in young and older adults. Methods: The current study is a two-arm randomised controlled trial which will be conducted in 80 (40 young (≤40 years) and 40 older (≥65 years)) adults to compare post-exercise recovery in those supplemented with vitamin K2 or placebo for a 12-week period. The primary outcome is muscle strength with secondary outcomes including pain free range of motion, functional abilities, surface electromyography (sEMG) and markers of inflammation and oxidative stress. Discussion: Ethical approval has been granted by the College of Medical Veterinary and Life Sciences Ethical Committee at the University of Glasgow (Project No 200190189) and recruitment is ongoing. Study findings will be disseminated through presentation at scientific conferences and in scientific journals. Trial registration: Prospectively registered on 21st December 2020, trial registration clinicialtrials.gov ID NCT04676958 https://clinicaltrials.gov/ct2/show/NCT04676958
Human basic Fibroblastic Growth Factor production by codon optimization in rice cell suspension culture
Authors: Bastami Meysam , Hosseini Ramin
Published: June 2022

Human basic fibroblastic growth factor (hbFGF), possesses several highly important biological functions, such as cell proliferation, protein synthesis and metabolism. This study is the first investigation to transfer a hbFGF gene cassette into rice cells. To improve the human bFGF expression in rice an optimized coding sequence was developed. Following synthesis, the expression cassette was constructed by fusing the PCR- amplified RAm3D promoter and terminator sequences to the codon-optimized hbFGF sequence. Then, the cassette was transferred into the pCAMBIA1304 shuttle vector. This vector also contained the RAmy3D signal peptide for the secretion of the recombinant protein into the culture medium. Rice (Oryza sativa cv. Kanto 51) seeds were cultured on the 2N6PG medium composing of the N6 basal medium supplemented with 2 mg/L 2,4-D for callus induction. Callus transformation was performed by employing Agrobacterium tumefaciens strain LBA 4404. The verification of bFGF gene integration into the chromosomes of putative transgenic calli was carried out by genomic DNA PCR. A transformed callus line expressing the highest level of bFGF (38.1 mg/kg FW) was recognized by ELISA and selected to establish cell suspension culture. The expression and secretion of the recombinant bFGF into the culture medium in the developed transgenic rice cell culture was evident on day 3 after incubation of cells in the sucrose-free medium. The recombinant bFGF with a molecular weight of ~17 kDa was detected by the Western blot and SDS-PAGE analyses in the culture medium under reducing conditions. The purification of bFGF was performed using HiTrap Heparin HP column. The activity assay indicated that the rice derived bFGF stimulated the proliferation of NIH/3T3 cells similar to the commercial bFGF.