bluuebunny/crossref_metadata_2025 huggingface dataset:
A practical introduction to using the drift diffusion model of decision-making in cognitive psychology, neuroscience, and health sciences
Authors: Myers Catherine E. , Interian Alejandro , Moustafa Ahmed A.
Published: December 2022

Recent years have seen a rapid increase in the number of studies using evidence-accumulation models (such as the drift diffusion model, DDM) in the fields of psychology and neuroscience. These models go beyond observed behavior to extract descriptions of latent cognitive processes that have been linked to different brain substrates. Accordingly, it is important for psychology and neuroscience researchers to be able to understand published findings based on these models. However, many articles using (and explaining) these models assume that the reader already has a fairly deep understanding of (and interest in) the computational and mathematical underpinnings, which may limit many readers’ ability to understand the results and appreciate the implications. The goal of this article is therefore to provide a practical introduction to the DDM and its application to behavioral data – without requiring a deep background in mathematics or computational modeling. The article discusses the basic ideas underpinning the DDM, and explains the way that DDM results are normally presented and evaluated. It also provides a step-by-step example of how the DDM is implemented and used on an example dataset, and discusses methods for model validation and for presenting (and evaluating) model results. Supplementary material provides R code for all examples, along with the sample dataset described in the text, to allow interested readers to replicate the examples themselves. The article is primarily targeted at psychologists, neuroscientists, and health professionals with a background in experimental cognitive psychology and/or cognitive neuroscience, who are interested in understanding how DDMs are used in the literature, as well as some who may to go on to apply these approaches in their own work.
Effect of acute exercise intensity on cognitive inhibition and well-being: Role of lactate and BDNF polymorphism in the dose-response relationship
Authors: Ballester-Ferrer Juan Arturo , Bonete-López Beatriz , Roldan Alba , Cervelló Eduardo , Pastor Diego
Published: December 2022

Introduction

There is evidence in the literature that acute exercise can modify cognitive function after the effort. However, there is still some controversy concerning the most effective exercise modality to improve cognitive function in acute interventions. Regarding these different exercise modalities, the dose–response relationship between exercise intensity and cognitive response is one of the most challenging questions in exercise and cognition research.

Methods

In this study, we tested the impact of moderate-intensity (MICT), high-intensity (HIIT) exercise sessions, or control situation (CTRL) on cognitive inhibition (measured with the Stroop Test). Thirty-six young college students participated in this study, where a within-subject repeated measure design was used.

Results

ANOVA 2×3 demonstrated that HIIT improved the acute cognitive response to a higher degree when compared to MICT or CTRL (p < 0.05). The cognitive improvements correlated with lactate release, providing a plausible molecular explanation for the cognitive enhancement (r < −0.2 and p < 0.05 for all the Stroop conditions). Moreover, a positive trend in wellbeing was observed after both exercise protocols (HIIT and MICT) but not in the CTRL situation. Genetic BDNF single nucleotide polymorphism did not influence any interactions (p < 0.05).

Discussion

In this sense, our results suggest that exercise intensity could be a key factor in improved cognitive function following exercise in young college students, with no additional impact of BDNF polymorphism. Moreover, our results also provide evidence that exercise could be a useful tool in improving psychological wellbeing.
Development of a survey on the activity participation of children with special needs in preschool inclusive education
Authors: Xu Li , Xiong Zhiheng , Zeng Li
Published: December 2022

Participation refers to an individual’s psychological and behavioral participation in activities. The activity participation of children with disabilities is an important index to measure preschool inclusive education. This study explored the preparation of a questionnaire suitable for measuring the participation of children with disabilities in inclusive education environments, so as to provide an evaluation tool for researchers and teachers. The study included exploration of the four dimensions of learning participation, life participation, teacher support, and parental attitude of children with disabilities in inclusive education. The research involved kindergarten teachers with inclusive education experience in 10 provinces and 20 cities in China such as Jiangsu, Zhejiang, Anhui, Jilin, Inner Mongolia, Sichuan, Guizhou, Guangxi, Yunnan, and Xinjiang. Questionnaire is filled in the form of voluntary principle and online. The Cronbach’s α coefficient for the total dimension of the questionnaire was 0.950, with coefficients for each sub-dimension ranging from 0.916 to 0.981. The Mplus8.3 software was used to carry out confirmatory factor analysis on the four-factor model. The standardized load of the four sub-dimensions was between 0.88 and 0.95. The load reached the significant level of 0.01, the interpretation rate presents a medium and high level (the interpretation rate is greater than 70%), and the model fits well. Therefore, based on good reliability and validity, this questionnaire can be used to evaluate the activity participation of children with disabilities in preschool inclusive education.
Does the practice of mindfulness reduce somatic symptoms and COVID-19-related anxiety? A community-based survey
Authors: Micheli Noemi , Porcelli Piero , Barrault-Couchouron Marion , Dantzer Cécile
Published: December 2022

Objective

Since the beginning of COVID-19 pandemic, several studies have shown an increase of psychological distress in the general population. Previous research demonstrated that high levels of anxiety are associated with reporting more somatic symptoms. The ability to adaptively regulate emotions is essential to deal with stressful situations, and it is one of the main components of mindfulness practice. The aim of the present study was to document the effect of mindfulness practice on somatic symptoms and psychological distress in the context of COVID-19 pandemic.

Methods

The study has a descriptive cross-sectional design. During the second wave of COVID-19 pandemic, between November 2020 and January 2021 participants living in France responded to an online survey on the impact of COVID-19 on psychological distress and physical health. The questionnaire included the assessment of COVID-19-related anxiety, mindfulness practice and experience, dispositional mindfulness, somatization, depression, generalized anxiety, and emotion regulation.

Results

A total of 569 people (mean age = 39.8 years, 90% women) were included in the study. COVID-19 related anxiety was associated with higher levels of somatic symptoms, generalized anxiety, and depression. About half of the sample (n = 318, 56%) reported moderate to severe somatic symptoms that were associated with higher levels of depression and anxiety, lower levels of dispositional mindfulness and to the use of maladaptive emotion regulation strategies. Overall, 164 subjects (28.8%) reported practicing meditation. No differences were found in dispositional mindfulness (MAAS score) between beginners and advanced practitioners, regardless of the type, years, frequency, and length of practice. Participants with less experience in mindfulness practice reported a significant higher number of somatic symptoms than non-practitioners and a higher use of rumination. Moreover, mindfulness experience was associated with the use of more adaptive emotion regulation strategies.

Conclusion

Mindfulness meditation has been promoted as a practice enhancing well-being and helping to cope with the psychological impact of stressful events. However, in a distressing situation as COVID-19 pandemic, a limited experience in mindfulness practices might result in the development or endurance of somatic symptoms. Adequate training and a focus on mindful acceptance, may contribute to enhance the effectiveness of mindfulness practice.
The association between adverse pregnancy outcomes with genital Chlamydia Trachomatis infection among pre-pregnancy couples in Shenzhen, China: A cross-sectional study
Authors: Sun Si , Zhang Li , Wu Qiuhong , Tian Lishan , Ding Yi , Liu Lanlan , Ye Hailing , Li Bo , Luo Zhenzhou
Published: December 2022

Objectives

To investigate the prevalence of adverse pregnancy outcomes (APOs) in women and the impact of pre-pregnancy couples' genital Chlamydia Trachomatis (GCT) infection and other infections on APOs.

Study design

Data on genital infections were collected from the Free Pre-pregnancy Health Check (FPHC) in Shenzhen, China. Data on APOs were collected from a 1-year telephone follow-up of pregnancy status and subsequent pregnancy outcomes.

Methods

APO data were used to count adverse outcomes, and logistic regression was conducted to determine the association between APOs and GCT infection.

Results

From December 2018 to December 2019, among 4,429 couples who underwent FPHC; 1,925 were pregnant, and 1,816 couples were tracked for pregnancy outcomes, including 1,471 normal pregnancies and 345 (19.00%) APOs. The rest of 109 pregnant couples did not answer the phone or refused to answer the pregnancy outcome during the follow-up. Among APOs, the number of spontaneous abortions was 122 (35.36%), the number of macrosomia was 85 (24.64%), the number of low birth weight (LBW) & preterm births (PTB) was 39 (11.30%), the number of LBW was 34 (9.86%), and the number of PTB was 31 (8.99%). The prevalence of GCT infection in females and males was 4.24% [95% Confidence Interval, (CI): 3.41–5.27%] and 3.58% (95% CI: 2.79–4.57%), respectively. More than half (52.69%, 49/93) of the couples were GCT-concordant. The prevalence of APOs in couples without GCT infection was 18.74% (332/1,772). The prevalence of APOs in female GCT-discordant was 32.14% (9/28), and the prevalence of APOs in male GCT-discordant was 25% (4/16). The prevalence of APOs in GCT-concordant was 12.24% (6/49). Multivariable analysis indicated that females 30–35 years old [adjusted Odds Ratio (aOR) = 1.08, 95% CI: 1.01–1.17] and over 35 years old (aOR = 1.16, 95% CI: 1.03–1.32) were more likely to experiencing APOs.

Conclusion

Although only women's age was found to be associated with APOs, the prevalence of APOs with GCT-discordant in couples, especially female GCT-discordant, was higher than in those without infection or who were GCT-concordant, suggesting that these groups, especially in older women, should be paid more attention to in follow-ups to improve reproductive health.
Institutional delivery and associated factors among women who gave birth in Benishangul Gumuz region, South West Ethiopia
Authors: Arega Temesgen , Mulatu Teshale , Alemayehu Afework , Mussa Ibsa , Dheresa Merga
Published: December 2022

Background

Maternal mortality from pregnancy and childbirth remains a major public health problem. Increasing access to institutional delivery is one of the key strategies to reduce childbirth-related maternal mortality. Despite all the efforts, institutional deliveries in Ethiopia remain low. Understanding factors associated with institutional delivery is important to devise strategies to improve facility based child birth. Hence, this study assessed the prevalence of institutional delivery and associated factors to bridge the gap.

Methods

A community-based cross-sectional study was employed from March-April 2020. Multi-stage sampling was employed to select 500 mothers who gave birth within the last 12 months in Mandura district, Benishangul Gumuz Region, Ethiopia. Data were collected using pre tested structured questionnaire through face-to-face interview. Logistic regression models were fitted to assess the predictors of institutional delivery. Adjusted Odds ratios with 95% CI was used to show associations and statistical significance was set at a p < 0.05.

Results

This study indicated that the prevalence of institutional delivery was 28.8% CI (25–33.3%). Having a positive attitude (AOR = 9.6,95%CI:2.5–35.9), attending antenatal care (ANC) at least once (AOR = 16.1,95%CI:9.6–22), attending ANC more than three times (AOR = 17.2, 95% CI:13.5–43.8), having good knowledge (AOR = 11.1, 95%CI: 2.7–45.4), and facing complications during pregnancy (AOR = 4.04, 95%CI: 1.0–16.0) were significantly associated with institutional delivery.

Conclusion

The prevalence of institutional delivery in this study was low. Positive attitude toward institutional delivery, attending ANC, having good knowledge about institutional delivery, and facing complications during pregnancy were identified predictors of institutional delivery. Strategies with a focus on increasing ANC uptake, improving mothers' knowledge, and promoting institutional delivery at the community level are critical.
Associations of Lameness with Indicators of Nitrogen Metabolism and Excretion in Dairy Cows
Authors: Necula Daniel-Catalin , Warren Helen Elizabeth , Taylor-Pickard Jules , Simiz Eliza , Stef Lavinia
Published: December 2022

The aim of the study was to investigate the impact of lameness on nitrogen (N) metabolism and excretion. Two treatment groups of 20 multiparous Holstein–Friesian dairy cows were included in study; the control group consisted of cows with locomotion score ≤2, while the experimental group consisted of cows with locomotion scores 3 and 4. Fodder, milk, feces, and urine were collected to determine nitrogen emissions. The milk yield, the energy-corrected milk, the fat and protein yield were higher for lame animals compare with non-lame cows. Differences were also detected in the milk urea nitrogen (MUN) between groups where lame cows had a 15% lower MUN than non-lame animals. Urine volume was lower (p < 0.008), while urinary creatinine concentration was higher (p < 0.05) in lame animals compare with those in the non-lame group. Consequently, the creatinine/urea ratio was significantly higher (p < 0.001) in the lame vs. no-lame animals. Nitrogen excretion in milk was higher (p = 0.008) and N in urine was lower (p < 0.001) in the lame compared to non-lame cows with lower urinary N emissions in lame animals. Taken together, our results show that urinary creatinine concentration and urinary creatinine/urea ratio have the potential to be used as a tool for lameness detection.
Development of an Allergic Rhinitis Diagnosis Application Using the Total Tear IgE Detection Kit for Examining Nasal Fluid: Comparison and Combination with the Conventional Nasal Smear Examination for Eosinophils
Authors: Kumanomidou Hiroshi , Okano Mitsuhiro
Published: December 2022

Allergic rhinitis (AR) is a type I allergic disease characterized by immunoglobulin E (IgE) -mediated hypersensitivity of the nasal mucosa. Here, we focused on a commercial test kit named Allerwatch® (AW) for the diagnosis of allergic conjunctivitis (AC) in which total tear IgE is qualitatively detected based on immunochromatography. We evaluated the usefulness of the AW test for detecting total IgE in the nasal discharge of AR and non-allergic rhinitis (non-AR) patients in comparison and combination with the conventional nasal smear examination for eosinophils. Using the AW test, total IgE in nasal fluid was detected in 64.76% of the AR patients and 11.11% of the non-AR patients, with a significant difference between the groups (p < 0.001). As compared to non-AR, the sensitivity and specificity of the detection of total IgE in nasal fluid for detecting AR were 64.76% and 88.89%, respectively. In the AR patients, house dust mites (57.1% of patients) and Japanese cedar pollen (93.3% of patients) were the major sensitizing antigens. When we considered a positive result in either of the two examinations to indicate a positive result, the rate of positivity in AR patients increased to 78.10%. As compared to non-AR, the sensitivity and specificity of the combination of both examinations for detecting AR were 78.10% and 83.33%, respectively. The AW test in the nasal cavity and the qualitative measurement of total IgE in nasal fluid may enable the detection of allergic elements in patients who present to a medical institution with nasal symptoms. In addition, the detection rate is increased when combined with the nasal smear examination for eosinophils.
Implications of W-Boson Mass Anomaly for Atomic Parity Violation
Authors: Tran Tan Hoang Bao , Derevianko Andrei
Published: December 2022

We consider the implications of the recent measurement of the W-boson mass MW=80,433.5±9.4MeV/c2 for atomic parity violation experiments. We show that the change in MW shifts the Standard Model prediction for the 133Cs nuclear weak charge to QW(133Cs)=−73.11(1), i.e., by 8.5σ from its current value, and the proton weak charge by 2.7%. The shift in QW(133Cs) ameliorates the tension between existing determinations of its value and motivates more accurate atomic theory calculations, while the shift in QW(p) inspires next-generation atomic parity violation experiments with hydrogen. Using our revised value for QW(133Cs), we also readjust constraints on parameters of physics beyond the Standard Model. Finally, we reexamine the running of the electroweak coupling for the new W boson mass.
In Situ Growth of Dopamine on QCM for Humidity Detection
Authors: Qi Pengjia , Xu Ziwei , Zhang Tong
Published: December 2022

Polydopamine (PDA) films were successfully prepared on quartz crystal microbalance (QCM) by in-situ growth method, and the obtained QCM sensor was used for humidity detection. Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used to study the chemical composition and microstructure of the in-situ grown PDA sensitive films. The experimental results showed that the PDA-QCM humidity sensor with 2 h polymerization growth times (2-PDA-QCM) owned high sensitivity (20.77 Hz/% RH), good selectivity, short response/recovery time (5 s/11 s) and acceptable long-term stability. In addition, the energy loss of the sensors fabricated under different conditions was investigated by impedance analysis. Based on all the test results, it is concluded that the combination of in-situ growth method and QCM can produce a room temperature humidity sensor with excellent performance.
DELAY OF GERMINATION 1, the Master Regulator of Seed Dormancy, Integrates the Regulatory Network of Phytohormones at the Transcriptional Level to Control Seed Dormancy
Authors: Li Qiujia , Chen Xi , Zhang Shengnan , Shan Siyao , Xiang Yong
Published: December 2022

Seed dormancy, an important adaptive trait that governs germination timing, is endogenously controlled by phytohormones and genetic factors. DELAY OF GERMINATION 1 (DOG1) is the vital genetic regulator of dormancy, significantly affecting the expression of numerous ABA and GA metabolic genes. However, whether DOG1 could influence the expression of other phytohormone-related genes is still unknown. Here, we comprehensively investigated all well-documented hormone-related genes which might be affected in dog1–2 dry or imbibed seeds by using whole-transcriptome sequencing (RNA-seq). We found that DOG1 could systematically control the expression of phytohormone-related genes. An evident decrease was observed in the endogenous signal intensity of abscisic acid (ABA) and indole-3-acetic acid (IAA), while a dramatic increase appeared in that of gibberellins (GA), brassinosteroids (BR), and cytokinin (CK) in the dog1–2 background, which may contribute considerably to its dormancy-deficient phenotype. Collectively, our data highlight the role of DOG1 in balancing the expression of phytohormone-related genes and provide inspirational evidence that DOG1 may integrate the phytohormones network to control seed dormancy.
The Study of Nanosized Silicate-Substituted Hydroxyapatites Co-Doped with Sr2+ and Zn2+ Ions Related to Their Influence on Biological Activities
Authors: Rewak-Soroczynska Justyna , Nowak Nicole , Targonska Sara , Piecuch Agata , Wiglusz Rafal J.
Published: December 2022

Nanosized silicate-substituted hydroxyapatites, characterized by the general formula Ca9.8−x−nSrnZnx(PO4)6−y(SiO4)y(OH)2 (where: n = 0.2 [mol%]; x = 0.5–3.5 [mol%]; y = 4–5 [mol%]), co-doped with Zn2+ and Sr2+ ions, were synthesized with the help of a microwave-assisted hydrothermal technique. The structural properties were determined using XRD (X-ray powder diffraction) and Fourier-transformed infrared spectroscopy (FT-IR). The morphology, size and shape of biomaterials were detected using scanning electron microscopy techniques (SEM). The reference strains of Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa were used to assess bacterial survivability and the impact on biofilm formation in the presence of nanosilicate-substituted strontium-hydroxyapatites. Safety evaluation was also performed using the standard cytotoxicity test (MTT) and hemolysis assay. Moreover, the mutagenic potential of the materials was assessed (Ames test). The obtained results suggest the dose-dependent antibacterial activity of nanomaterials, especially observed for samples doped with 3.5 mol% Zn2+ ions. Moreover, the modification with five SiO4 groups enhanced the antibacterial effect; however, a rise in the toxicity was observed as well. No harmful activity was detected in the hemolysis assay as well as in the mutagenic assay (Ames test).
A Systematic Review on Social Robots in Public Spaces: Threat Landscape and Attack Surface
Authors: Oruma Samson O. , Sánchez-Gordón Mary , Colomo-Palacios Ricardo , Gkioulos Vasileios , Hansen Joakim K.
Published: December 2022

There is a growing interest in using social robots in public spaces for indoor and outdoor applications. The threat landscape is an important research area being investigated and debated by various stakeholders. Objectives: This study aims to identify and synthesize empirical research on the complete threat landscape of social robots in public spaces. Specifically, this paper identifies the potential threat actors, their motives for attacks, vulnerabilities, attack vectors, potential impacts of attacks, possible attack scenarios, and mitigations to these threats. Methods: This systematic literature review follows the guidelines by Kitchenham and Charters. The search was conducted in five digital databases, and 1469 studies were retrieved. This study analyzed 21 studies that satisfied the selection criteria. Results: Main findings reveal four threat categories: cybersecurity, social, physical, and public space. Conclusion: This study completely grasped the complexity of the transdisciplinary problem of social robot security and privacy while accommodating the diversity of stakeholders’ perspectives. Findings give researchers and other stakeholders a comprehensive view by highlighting current developments and new research directions in this field. This study also proposed a taxonomy for threat actors and the threat landscape of social robots in public spaces.
Some Novel Inequalities for LR-(k,h-m)-p Convex Interval Valued Functions by Means of Pseudo Order Relation
Authors: Stojiljković Vuk , Ramaswamy Rajagopalan , Abdelnaby Ola A. Ashour , Radenović Stojan
Published: December 2022

In this paper, a new type of convexity is defined, namely, the left–right-(k,h-m)-p IVM (set-valued function) convexity. Utilizing the definition of this new convexity, we prove the Hadamard inequalities for noninteger Katugampola integrals. These inequalities generalize the noninteger Hadamard inequalities for a convex IVM, (p,h)-convex IVM, p-convex IVM, h-convex, s-convex in the second sense and many other related well-known classes of functions implicitly. An apt number of numerical examples are provided as supplements to the derived results.
Alpha Suppression Is Associated with the Tip-of-the-Tongue (TOT) State Whereas Alpha Expression Is Associated with Knowing That One Does Not Know
Authors: Shen Edmund Qian-Long , Friedman David , Bloom Paul Alexander , Metcalfe Janet
Published: December 2022

The tip-of-the-tongue (TOT) state is a spontaneously occurring metacognitive state that indicates that the answer to a query is almost, but not quite, at hand, i.e., that resolution is imminent. Since the time of William James, a distinctive feeling of nagging frustration has been observed to be associated with TOT states. On a more positive note, TOT states are also associated with intense goal-directed curiosity and with a strong desire to know that translates into successful mental action. The present study showed that prior to the presentation of resolving feedback to verbal queries—if the individual was in a TOT state—alpha suppression was in evidence in the EEG. This alpha suppression appears to be a marker of a spontaneously occurring, conscious, and highly motivating goal-directed internal metacognitive state. At the same time, alpha expression in the same time period was associated with the feeling of not knowing, indicating a more discursive state. Both alpha and alpha suppression were observed broadly across centro-parietal scalp electrodes and disappeared immediately upon presentation of the resolving feedback. Analyses indicated that the occurrence of alpha suppression was associated with participants’ verbal affirmations of being in a TOT state, which is also related to subsequent expression of a late positivity when feedback is provided, and to enhanced memory.
Do Domain Knowledge and Retrieval Practice Predict Students’ Study Order Decisions?
Authors: Babineau Addison L. , Witherby Amber E. , Ariel Robert , Pelch Michael A. , Tauber Sarah K.
Published: December 2022

Learning complex concepts is necessary for student success, but it is often challenging. Learning such concepts can be influenced by students’ study order choices during learning to switch to a new category (interleaved study order) or stay within the same category (blocked study order). Students often prefer stay decisions during learning and make relatively few switch decisions; however, an open question is whether students’ switch decisions are related to their level of prior knowledge in the domain and the learning strategy they use (retrieval practice versus study). To examine these relationships, we recruited undergraduate students from an introductory geology course. Prior to the course modules on rock classification, students self-rated their knowledge, took a prior knowledge test, classified rock exemplars by completing study or retrieval practice trials, and made study order choices. Students then completed assignments and attended lectures in their geology course on igneous, sedimentary, and metamorphic rocks. Next, students self-rated their knowledge, took a new prior knowledge test, completed study or retrieval practice trials, made study order decisions, took final classification tests, and self-reported beliefs about study order choices. Even though students’ knowledge increased after course modules on rock identification, and most students believed that domain knowledge impacts study decisions, prior knowledge did not predict students’ switch decisions. In contrast, students who completed retrieval practice trials made substantially more switch decisions (i.e., interleaved study) than did students who completed study trials.
Settlements along Main Road Axes: Blessing or Curse? Evaluating the Barrier Effect in a Small Greek Settlement
Authors: Emmanouilidis Savvas , Basbas Socrates , Sdoukopoulos Alexandros , Politis Ioannis
Published: December 2022

Being the heart of every human settlement, the road network constitutes a significant component of the built environment that serves the accessibility and mobility needs and supports economic activities. Despite its positive role, the road network, in some cases, due to increased geometric and functional characteristics, can act as a barrier to the movement of vulnerable road users, thus fragmenting the urban space and creating the phenomenon of the “barrier effect”. The barrier effect is considered detrimental to the mobility of vulnerable users, causing delays or even cancellation of trips, increasing collision risk, limiting access to services, posing negative impacts on public health, and loosening social ties. In this context, the current paper focuses on a settlement in Greece (Dispilio) developed along two national roads and comprehensively evaluates the barrier effect. More specifically, the presented methodological approach attempts to investigate the actual and the perceived dimension of this phenomenon by applying well-established metrics and landscape indicators, such as the effective mesh size, and conducting a questionnaire survey, respectively. The overall research results highlighted interesting findings regarding the intensity of the barrier effect in the examined area and outlined some critical interventions that could be implemented in similar cases.
Purification Process and In Vitro and In Vivo Bioactivity Evaluation of Pectolinarin and Linarin from Cirsium japonicum
Authors: Ye Yana , Chen Zhenlin , Wu Yonglin , Gao Mengmeng , Zhu Anqi , Kuai Xinyuan , Luo Duosheng , Chen Yanfen , Li Kunping
Published: December 2022

Pectolinarin and linarin are two major flavone O-glycosides of Cirsium japonicum, which has been used for thousands of years in traditional Chinese medicine. Pharmacological research on pectolinarin and linarin is meaningful and necessary. Here, a process for the purification of pectolinarin and linarin from C. japonicum was established using macroporous resin enrichment followed by prep-HPLC separation. The results show the purity of pectolinarin and linarin reached 97.39% and 96.65%, respectively. The in vitro bioactivities result shows the ORAC values of pectolinarin and linarin are 4543 and 1441 µmol TE/g, respectively, meanwhile their inhibition rate of BSA-MGO-derived AGEs is 63.58% and 19.31% at 2 mg/mL, which is 56.03% and 30.73% in the BSA-fructose system, respectively. The COX-2 inhibition rate at 50 µg/mL of linarin and pectolinarin reached 55.35% and 40.40%, respectively. Furthermore, the in vivo bioassay combining of histopathologic evaluation and biochemical analysis of liver glutamic oxaloacetic transaminase, serum creatinine and TNF-α show pectolinarin can alleviate lipopolysaccharide (LPS)-induced acute liver and kidney injury in mice. Metabolomics analysis shows that pectolinarin attenuates LPS-challenged liver and kidney stress through regulating the arachidonic acid metabolism and glutathione synthesis pathways. Collectively, our work presents a solid process for pectolinarin and linarin purification and has discovered a promising natural therapeutic agent—pectolinarin.
A New Microporous Lanthanide Metal–Organic Framework with a Wide Range of pH Linear Response
Authors: Zhang Ruyi , Zhu Liangliang , Yue Bingbing
Published: December 2022

Lanthanide metal–organic frameworks (Ln-MOFs) have attracted extensive attention because of their structural adjustability and wide optical function applications. However, MOFs with a wide linear pH response and stable framework structures in acidic or alkaline solutions are rare to date. Here, we used 4,4′,4″-s-triazine-2,4,6-triyltribenzoate (H3TATB) as an organic ligand, coordinated with lanthanide ions (Eu3+/Tb3+), and synthesized a new metal–organic framework material. The material has a porous three-dimensional square framework structure and emits bright red or green fluorescence under 365 nm UV light. The carboxyl group of the ligand is prone to protonation in an acidic environment, and negatively charged OH− and ligand (TATB3−) have a competitive effect in an alkaline environment, which could affect the coordination ability of ligand. The luminescence degree of the framework decreases with the increase in the degree of acid and base. In particular, such fluorescence changes have a wide linear response (pH = 0–14), which can be used as a potential fluorescence sensing material for pH detection.
Nanodelivery of Dietary Polyphenols for Therapeutic Applications
Authors: Rudrapal Mithun , Mishra Ashwini K. , Rani Laxmi , Sarwa Khomendra K. , Zothantluanga James H. , Khan Johra , Kamal Mehnaz , Palai Santwana , Bendale Atul R. , Talele Swati G. , Pathan Vasim T. , Borse Laxmikant B. , Neharkar Vishnu S. , Sahoo Pravat K.
Published: December 2022

Advancement in nanotechnology has unleashed the therapeutic potentials of dietary polyphenols by enhancing bioavailability, improving biological half-life, and allowing site-specific drug delivery. In this review, through citation of relevant literature reports, we discuss the application of nano-pharmaceutical formulations, such as solid lipid nanoparticles, nano-emulsions, nano-crystals, nano-polymersomes, liposomes, ethosomes, phytosomes, and invasomes for dietary polyphenols. Following this, we highlight important studies concerning different combinations of nano formulations with dietary polyphenols (also known as nanophytopolyphenols). We also provide nano-formulation paradigms for enhancing the physicochemical properties of dietary polyphenols. Finally, we highlight the latest patents that were granted on nano-formulations of dietary polyphenols. Based on our review, we observe that nanosized delivery of herbal constituents, spices, and dietary supplements have the ability to improve biological processes and address issues connected with herbal treatments.
Chiral Separations of Pyrethroic Acids Using Cyclodextrin Selectors
Authors: Juvancz Zoltán , Bodáné-Kendrovics Rita , Laczkó Zita , Iványi Róbert , Varga Erzsébet
Published: December 2022

Pyrethroid insecticides are broadly used. They have low toxicity for warm-blooded living creatures, but high toxicity for both insects and fish. Therefore, it is important to reduce the environmental impact of pyrethroids. Pyrethroic acids are chiral compounds. An effective way to decrease pollution is to use enantio-pure insecticide products instead of their racemic mixtures. Enantiomer-pure products require enantiomer selective synthesis and analysis. The chiral selective analysis of pyrethroic acids (an intermediate of pyrethroids) is also important in terms of process control and from the point of view of their degradation metabolism in the environment. This study used various enantiomeric selective chromatographic methods for the separation of different pyrethroic acids, including gas chromatography, supercritical fluid chromatography and capillary electrophoresis. Systematic experiments were conducted to find the optimum conditions for their chiral separation. The employed enantio-selective agents were cyclodextrin derivatives with different ring sizes and substitution patterns. The β-cyclodextrin proved to be excellent for the chiral separation of these acids. The different chiral recognition mechanisms were established using different ring-sized cyclodextrins. The results of these systematic studies demonstrated the correlations of the chiral selectivity features of selectors and the structures of analytes.
Clocks, Automata and the Mechanization of Nature (1300–1600)
Authors: Roudaut Sylvain
Published: December 2022

This paper aims at tracking down, by looking at late medieval and early modern discussions over the ontological status of artifacts, the main steps of the process through which nature became theorized on a mechanistic model in the early 17th century. The adopted methodology consists in examining how inventions such as mechanical clocks and automata forced philosophers to modify traditional criteria based on an intrinsic principle of motion and rest for defining natural beings. The paper studies different strategies designed in the transitional period 1300–1600 for making these inventions compatible with classical definitions of nature and artifacts. In the first part of the paper, it is shown that, even if virtually all medieval philosophers acknowledged an ontological distinction between artifacts and natural beings, these different strategies demonstrate a growing concern about the consistency of the art/nature distinction. The next part of the paper studies how mechanical clocks, even before the Scientific Revolution, served as theoretical models for applying mechanistic views to different objects (be they cosmological, physical or biological). The epistemological function of clocks appears to stem from different factors (like the specific manufacturing of late medieval clocks as well as the evolution of 16th-century mechanics) that are listed in this second part of the paper. These factors, combined with the definitional issues raised by automata, explain that clocks became the symbol of a new approach to natural philosophy, characterized by the collapse of the art/nature distinction and the “mechanization of nature”.
Stimulating the Growth, Anabolism, Antioxidants, and Yield of Rice Plants Grown under Salt Stress by Combined Application of Bacterial Inoculants and Nano-Silicon
Authors: Alharbi Khadiga , Osman Hany S. , Rashwan Emadeldeen , Hafez Emad M. , Omara Alaa El-Dein
Published: December 2022

The growth and development of rice face many issues, including its exposure to high soil salinity. This issue can be alleviated using new approaches to overwhelm the factors that restrict rice productivity. The objective of our investigation was the usage of the rhizobacteria (Pseudomonas koreensis and Bacillus coagulans) as plant growth-promoting rhizobacteria (PGPRs) and nano-silicon, which could be a positive technology to cope with the problems raised by soil salinity in addition to improvement the morpho-physiological properties, and productivity of two rice varieties (i.e., Giza 177 as salt-sensitive and Giza 179 as salt-tolerant). The findings stated that the application of combined PGPRs and nano-Si resulted in the highest soil enzymes activity (dehydrogenase and urease), root length, leaf area index, photosynthesis pigments, K+ ions, relative water content (RWC), and stomatal conductance (gs) while resulted in the reduction of Na+, electrolyte leakage (EL), and proline content. All these improvements are due to increased antioxidant enzymes activity such as catalase (CAT), superoxide dismutase (SOD), and peroxidase (POD), which decreased hydrogen peroxide (H2O2) and malondialdehyde (MDA) under soil salinity in rice plants compared to the other treatments. Combined application of PGPRs and nano-Si to Giza 177 significantly surpassed Giza 179, which was neither treated with PGPR nor nano-Si in the main yield components (number of grains/panicles, 1000 grain weight, and grain yield as well as nutrient uptake. In conclusion, both PGPRs and nano-Si had stimulating effects that mitigated the salinity-deleterious effects and encouraged plant growth, and, therefore, enhanced the grain yield.
Cytosolic Sodium Influx in Mesophyll Protoplasts of Arabidopsis thaliana, wt, sos1:1 and nhx1 Differs and Induces Different Calcium Changes
Authors: Morgan Sherif H. , Kader Md Abdul , Lindberg Sylvia
Published: December 2022

The sodium influx into the cytosol of mesophyll protoplasts from Arabidopsis thaliana cv. Columbia, wild type, was compared with the influx into sos1-1 and nhx1 genotypes, which lack the Na+/H+ antiporter in the plasma membrane and tonoplast, respectively. Changes in cytosolic sodium and calcium concentrations upon a 100 mM NaCl addition were detected by use of epifluorescence microscopy and the sodium-specific fluorescent dye SBFI, AM, and calcium sensitive Fura 2, AM, respectively. There was a smaller and mainly transient influx of Na+ in the cytosol of the wild type compared with the sos1-1 and nhx1 genotypes, in which the influx lasted for a longer time. Sodium chloride addition to the protoplasts’ medium induced a significant increase in cytosolic calcium concentration in the wild type at 1.0 mM external calcium, and to a lesser extent in nhx1, however, it was negligible in the sos1-1 genotype. LiCl inhibited the cytosolic calcium elevation in the wild type. The results suggest that the salt-induced calcium elevation in the cytosol of mesophyll cells depends on an influx from both internal and external stores and occurs in the presence of an intact Na+/H+ antiporter at the plasma membrane. The Arabidopsis SOS1 more effectively regulates sodium homeostasis than NHX1.
Elicitation of Bacillus cereus-Amazcala (B.c-A) with SiO2 Nanoparticles Improves Its Role as a Plant Growth-Promoting Bacteria (PGPB) in Chili Pepper Plants
Authors: Ferrusquía-Jiménez Noelia I. , González-Arias Beatriz , Rosales Alicia , Esquivel Karen , Escamilla-Silva Eleazar M. , Ortega-Torres Adrian E. , Guevara-González Ramón G.
Published: December 2022

Agriculture needs to decrease the use of agrochemicals due to their high toxicity and adopt new strategies to achieve sustainable food production. Therefore, nanoparticles (NPs) and plant growth-promoting bacteria (PGPB) have been proposed as viable strategies to obtain better crop yields with less environmental impact. Here, we describe the effect of silica nanoparticles (SiO2-NPs) on survival, antioxidant enzymatic activity, phosphate solubilization capacity, and gibberellin production of Bacillus cereus-Amazcala (B.c-A). Moreover, the effect of the co-application of SiO2-NPs and B.c-A on seed germination, physiological characteristics, and antioxidant enzymatic activity of chili pepper plants was investigated under greenhouse conditions. The results indicated that SiO2-NPs at 100 ppm enhanced the role of B.c-A as PGPB by increasing its phosphate solubilization capacity and the production of GA7. Moreover, B.c-A catalase (CAT) and superoxide dismutase (SOD) activities were increased with SiO2-NPs 100 ppm treatment, indicating that SiO2-NPs act as a eustressor, inducing defense-related responses. The co-application of SiO2-NPs 100 ppm and B.c-A improved chili pepper growth. There was an increase in seed germination percentage, plant height, number of leaves, and number and yield of fruits. There was also an increase in CAT and PAL activities in chili pepper plants, indicating that bacteria–NP treatment induces plant immunity.
Effect of Fluoride Ions on the Surface Dissolution of Vanadium-Bearing Biotite
Authors: Tao Yuanyuan , Ye Guohua , Zhang Hao , Hu Yujie , Zuo Qi , Wang Xiao , Zhu Siqin , Kang Xuanxiong , Zhang Yun , Xiang Xinyue , Rong Yiyang , Song Changxu
Published: December 2022

In shale vanadium ore, vanadium is mainly formed as a low-V(III) homogeneous phase to partially replace Si and exists in the lattice structure of aluminosilicate minerals such as biotite. During the acid leaching of shale vanadium ore, an activator is needed to effectively extract vanadium. Using biotite as a tetrahedral structure doped with Aluminum-Silicon tetrahedron structure, the interaction between leaching-agent ions (H+), activator ions (F−), and vanadium-containing biotite surface was discussed by DFT quantum chemical calculations. The dissolution behavior of activator fluoride ions on the surface of vanadium-bearing biotite during sulfuric acid leaching was revealed. According to the simulated leaching results, the oxygen on the biotite surface first absorbed hydrogen ions to undergo complete hydroxylation, and then combined with hydrogen ions to form water molecules. However, in the presence of activator (NaF), fluoride ions were adsorbed on the surface cations, which catalyzed the formation of water molecules and promoted the dissolution of surface cations. SEM–EDS analysis showed that the surface of vanadium-bearing minerals became very irregular, and the number of voids and cracks greatly increased. At the same time, XPS showed that the addition of activator fluoride ions destroyed the Al-O tetrahedron structure. Many Al and V atoms dissolved in the solution, which improved the leaching rate of vanadium.
A New Trend of Tourism in the Post-COVID-19 Era: Big Data Analysis of Online Tours in Korea
Authors: Kwon Hee-ju
Published: December 2022

In this study, big data analysis on Korea’s “online tour”, which emerged as an alternative to satisfy tourism needs after COVID-19, was conducted. After extracting keywords through text mining for 24,073 posts from the top three most frequently visited social media platforms, Naver, Daum, and Google, to gather tour information in Korea, frequency analysis and TF-IDF analysis were run. In addition, network analyses, such as centrality and convergence of iteration correlation (CONCOR) analyses, were performed. The results showed: First, the sense of presence via local live streaming is crucial. It is vital to prepare a suitable video environment where tourists can immerse themselves in the tour. Second, the interaction between travel agencies, local guides, and tourists is important because it can expand tourists’ travel experiences. Third, the importance of online tour program content was revealed. It is necessary to increase the demand by designing various programs tailored to the audience. Fourth, new possibilities for local travel that had been neglected were uncovered. Fifth, the importance of online tourism production support was highlighted. The role of the government must be expanded to reinforce the digital capabilities of small- and medium-sized enterprises (SMEs) and to create jobs. Although the scope of this study is limited to Korea, it can definitely be used as a regional strategy.
Utilization of Presence Awareness in Trauma Therapy
Authors: Lepak Michelle M.
Published: December 2022

Trauma can result in many long-term symptoms including emotional dysregulation, depression, addiction, and PTSD. When triggered by trauma, patients typically experience the world through a myopic lens. Helping clients observe and sense their trauma sequelae in the broader sensory awareness of Presence appears to help clients more easily process and resolve traumatic experience. The Presence Psychotherapy Trauma Protocol (PPTP) provides specific open-ended questions in session to help clients orient to Presence Awareness which can then be utilized to resolve trauma. Options to help clients sense their traumatic experience in the expansive awareness of Grounded Presence, Spacious Presence, Relational Presence, or Transcendent Presence create multiple regulating, processing, and attachment healing opportunities. PPTP’s concept of Reflective View is introduced which provides the clinician with prompts to help the client identify who they are as Presence Awareness early in session. This paper demonstrates, through a case example, how Presence Awareness and specifically Reflective View help clients access, tolerate, and process trauma in a broader sense of Presence Awareness.
Wastewater Treatment with the Natural Sorbents from the Arctic
Authors: Vialkova Elena , Fugaeva Anastasiia
Published: December 2022

Oil and gas production has an adverse impact on the ecological state of the Russian Arctic. The local natural materials, such as peat, moss, and reindeer moss are considered as naturel sorbents in wastewater treatment technologies. The sorption properties of these local materials were studied. The sorption isotherms at different initial concentrations of the pollutant (250, 50, and 0.5 mg/L) were constructed. The patterns of changes in the sorption intensity of oil products were determined. The sorbents were modified by microwave radiation (600 W, one minute), which had a visible positive effect on the samples. Preliminary calculations of the filter cassette dimensions with the performance 200 m3/day were carried out. Efficiency and cheapness predict the economic feasibility of using these materials in wastewater filtering equipment.