bluuebunny/crossref_metadata_2025 huggingface dataset:
Neonatal screening in Ukraine: development, effectiveness, prospects
Authors:   State Institution ", Omelchenko E.М. ,   O.M. Marzіeiev Institute for Public Health of the NAMSU", Polka O.O. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Karamzina L.А. ,   State Institution "O.M. Marzіeiev Institute for Public Health of the NAMSU", Kartashova S.S. ,   State University of Trade and Economics, Kyiv, Ukraine
Published: June 2024

The aim of the work was to evaluate the results of screening for hereditary pathology among newborns in Ukraine. Research materials and methods: data from the official statistics of the Ministry of Health of Ukraine served as materials, a systematic approach and analytical methods were used: epidemiological, probabilistic and statistical. Data from official statistics on newborn screening for VVR for the period 2010-2022 were included in the analysis. Genetic screening is an effective tool for detecting congenital metabolic disorders. Reducing the frequency of births of children with congenital and hereditary pathology is possible under the conditions of state programs aimed at reducing the impact of risk factors that cause congenital anomalies, as well as measures to prevent their occurrence. In Ukraine, mass screening of newborns began to be carried out in 1992 only at FKU. Examinations for VH were selective (indicated by the presence of a relevant anamnesis) and became mass since 2006. From 2022, examinations for 21 rare diseases will be conducted. Conclusions: During the period 2010-2022, 67.4% of newborns were tested for cystic fibrosis, 86.3% for congenital hypothyroidism, and 90.7% for phenylketonuria. Full screening coverage is predicted to identify about 335 more children with the specified diagnoses. An important condition for increasing the efficiency of state programs of neonatal screening is the widespread informing of primary care doctors and future parents about the possibilities of prevention of orphan diseases.
Post-traumatic effects of phosphorus weapons: from pathogenesis to treatment
Authors:   National Pyrohov Memorial Medical University, Vinnytsia, Ukraine, Chorna V.V. , Shkondin S.V. ,   National Pyrohov Memorial Medical University, Vinnytsia, Ukraine, Lypkan V.M. ,   National Pyrohov Memorial Medical University, Vinnytsia, Ukraine, Tomashevskyi A.V. ,   National Pyrohov Memorial Medical University, Vinnytsia, Ukraine, Kolomiets V.V. ,   National Pyrohov Memorial Medical University, Vinnytsia, Ukraine, Zavodiak A.Yu. ,   National Pyrohov Memorial Medical University, Vinnytsia, Ukraine
Published: June 2024

With the beginning of a full-scale war, the negative impact of harmful, dangerous substances due to the use of chemical, phosphorus bombs and other weapons, prohibited by the Geneva Convention, leads to unpredictable consequences for the health of combatants and the civilian population as well. Objectives of the study is to analyze injuries caused by white phosphorus of various types of phosphorus weapons, such as explosive weapons with a wide area of damage - mines, ammunition, long-range missiles; artillery, mortar shells, various types of grenades - in the conditions of the russian invasion of Ukraine. Materials and methods. The following methods were used when performing the work: content analysis, comparative analysis and systematization of the researched material. A study of scientific publications of domestic and foreign scientists was conducted using the PubMed and Google Scholar databases for the period 2001-2023. The results. Phosphorus munitions such as white phosphorus are known for their high effectiveness in combat operations, but their use leads to serious injuries and post-traumatic psychological changes. White phosphorus after a bomb explosion causes burns to the tissues of the human body, especially when in contact with burning material, as well as burns to the upper respiratory tract due to inhalation of smoke or gases released during combustion. The article analyzes the legal framework prohibiting the use of phosphorous ammunition in armed conflicts. Clinical cases of combined gunshot wounds of the limbs with a massive defect of soft tissues, gunshot fractures and the presence of multiple foreign bodies of metallic density due to the used phosphorous ammunition were considered. An analysis of scientific research by foreign scientists on this issue was carried out. The article presents the algorithms for providing first aid due to the effects of phosphorous ammunition, as well as the methodological recommendations of the Ministry of Health of Ukraine (Order of the Ministry of Health of Ukraine № 506 dated 20.03.2022) regarding the provision of medical assistance at the pre-hospital stage for burns, enteral poisoning, and eye contact phosphorus as a result of damage by the phosphorus component of the ammunition.
Optimization of sample preparation in the determination of 90Sr in food products
Authors:   State Institution Zaporizhzhia Region Center for Disease Control  and Prevention of the Ministry of Health of Ukraine, Zaporizhzhia, Ukraine, Kostenetskyi M.I. , Trusevych I.L. ,   State Institution Zaporizhzhia Region Center for Disease Control  and Prevention of the Ministry of Health of Ukraine, Zaporizhzhia, Ukraine, Bortsova M.V. ,   State Institution Zaporizhzhia Region Center for Disease Control  and Prevention of the Ministry of Health of Ukraine, Zaporizhzhia, Ukraine, Kutsak A.V. ,   Zaporizhia State Medical and Pharmaceutical University,  Zaporizhzhia, Ukraine
Published: June 2024

The aim: To determine the possibility of conducting studies of the radionuclide 90Sr in food products in accordance with GN 6.6.1.1-130-2006 «Permissible levels of radionuclides 137Cs and 90Sr in food products and drinking wate»" without concentration by the ashing method. Materials and methods: The article describes the method of calculating the minimum measuring concentration of food products. According to the results of the calculations, the products that can be measured without concentration are determined. Analytical, statistical and computational research methods were used during the work. At the stage of sample preparation for measurement, the question often arises in which form to measure the sample - native or ashed. The specific activities of food products in their native form are in many cases lower than the minimum measurable concentration (MMС) on the spectrometer. Therefore, in order to decide in what form to prepare the sample for research, before starting work, it is necessary to compare the capabilities of the spectrometer, the minimum measured concentration and the permissible level of 90Sr content in the research product. In order to solve the question of the need for ashing of the sample, calculations of MMC were carried out for each food product, as well as the weight of the raw product, necessary to obtain 0.01 kg of ash per measurement was calculated. Results: Tables are compiled based on the results of the calculations. One includes products whose activity can be measured without ashing, and the other includes products with ashing. The use of such tables makes it possible to optimize sample preparation for the study of 90Sr by the spectrometric method. Of the 50 groups of food products, 17 have been identified that can be studied in their native form, which saves time for sample preparation and increases the performance of the spectrometer.
Peculiarities of the development of social and everyday skills in high school students with intellectual disabilities
Authors:   Kamianets-Podilsky Ivan Ohienko National University, Verzhihovska Оlena , Hrytsiv Iryna
Published: June 2024

The article analyzes the content bases of the development of social and household skills in high school students with intellectual disabilities, in particular, the theoretical aspects of the formation of significant social and household skills are highlighted. to independent life, activities in society and further family life. Quantitative and qualitative characteristics of the empirical study showed that the largest number of students with intellectual disabilities in the 5th (58.33%) and 10th (61.11%) classes showed an average level of social and everyday skills, in particular, a superficial analysis of the rules of behavior is characteristic for them in the micro and macro environment, not the ability to assert oneself; lack of desire and desire to improve one's own skills in household and social activities with peers and in the family; superficiality of moral and volitional qualities; situational manifestation of positive emotions and lack of stability of motivation; displaying positive, superficial and unstable behavioral skills in interpersonal relationships during various activities; inability to organize independent life and daily life; spontaneous use of known social and household skills in life situations; not monitoring your own health. The teaching staff of the school (55.56%) and the children's parents (63.64%) assigned this level of high school students with intellectual disabilities. A low level was established in students of the 5th (36.11%) grade, and a sufficient level - in the 10th (61.11%) grade. The development of social and everyday skills in high school students with intellectual disabilities in the educational process is possible during educational, corrective and developmental and educational classes. The entire educational process allows children to form permanent skills of practical preparation for life and behavior in the family and in the social environment. The considered skills mainly improve the level of psychophysical development and make it possible to develop the social adaptation and integration of children.
Study of the bioequivalence of drugs for veterinary use «Avecardit» and «Vetmedin S» in the body of dogs
Authors: Golovin V. V. , Abramov S. V. , Balyshev A. V. , Kochetkov P. P. , Violin B. V.
Published: June 2024

This article reflects the results of a pharmacokinetic comparison of the reproducible drug based on pimobendan «Avecardit» with the reference drug «Vetmedin S» when used in dogs. The experiment used a sequential study design. A group of experimental dogs was formed, consisting of 7 animals (6 main and 1 reserve animal). Blood sampling was carried out before administration and after 10, 20, 40 min; 1, 1.5, 2, 2.5, 3, 3.5, 4, 6, 8, 10, 12 and 24 hours after drug administration. Key parameters assessed during the study: maximum concentration (Cmax) and time to reach it, area under the concentration-time curve (AUC) of the active substance of the drug in the blood serum of dogs. The article describes the main stages of the experiment, reagents and standard samples, the process of sample preparation of blood serum samples and HPLC-MS/MS analysis, and presents the results of a study of the bioequivalence of the drugs «Avecardit» and «Vetmedin S».

The time to reach the maximum concentration of pimobendan (Tmax) in the blood serum averaged 0.67–1 hour for the drug «Avecardit», 1–1.5 hours for the drug «Vetmedin S».

Maximum blood serum concentrations (Cmax) of pimobendan were in the range of 53,995–62,873 ng/ml for the study drug and 49,956–61,108 ng/ml for the reference drug. The 90% confidence intervals for the CmaxT/CmaxR and AUC0-tT/AUC0-tR ratios of pimobendan were within the range of 80–125%. The obtained results of the research work, from a scientific point of view, are a sufficient basis for recognizing the pharmacokinetic equivalence of the reproduced drug to the reference one.
The influence of adjuvants ISA 61 and ISA 50 on the antigenic activity, the ability to form colostral immunity and the effectiveness of experimental samples of the vaccine KOMBOVAC-A
Authors: Shemelkov E. V. , Shemelkova G. O. , Ivanov E. V. , Bulgakov A. D. , Verkhovsky O. A. , Aliper T. I.
Published: June 2024

The article provides a comparative assessment of two experimental samples of the seven-component vaccine KOMBOVAС-A, manufactured with adjuvants ISA 61 and ISA 50, in terms of: antigenic activity (in laboratory and naturally susceptible animals); influence on the formation of colostral immunity in calves when vaccinating pregnant cows, as well as effectiveness in livestock farming conditions unfavorable for the main respiratory and intestinal diseases of calves of viral etiology. It was found that the vaccine sample based on the ISA 61 adjuvant had a higher antigenic activity compared to a similar sample based on the ISA 50 adjuvant, inducing a higher level of synthesis of post-vaccination antibodies. The use of the vaccine in conditions of a dysfunctional livestock farm has reduced the morbidity and mortality of calves, while the vaccine sample made on the basis of ISA 61 oil proved to be more effective.
Review of antibiotic agents active against infectious mastitis pathogens
Authors: Lyashchuk J. O. , Ovchinnikov A. Yu. , Belyakov M. V. , Samarin G. N. , Kalashnikov M. V.
Published: June 2024

The effectiveness of animal treatment largely depends on correctly selected veterinary drugs. In recent years, there has been a decrease in the activity of antimicrobial agents against both gram-positive and gram-negative microorganisms. This trend is associated with the natural processes of adaptation of bacteria to living conditions. Once inside the animal’s body, bacterial cells react flexibly to both the immune response and treatment with antimicrobial agents. In cases where medical care was provided with antibiotics with low activity against a specific pathogen, there was a failure to comply with deadlines or deviations from the treatment regimen, some bacterial cells may not only not die, but also acquire drug resistance. Surviving microorganisms can change the type of colonial growth, the shape of the shell (many modern studies are devoted to L-forms of bacteria, which are formed under the influence of unfavorable factors, including antibiotics) or acquire new qualities through mutational changes. It is these processes that drive the emergence of bacterial strains resistant to antimicrobial drugs. As a result, many treatment regimens cease to give the desired result, since they include drugs whose active components do not have the proper bactericidal effect on resistant strains. In order for the treatment of animals to have therapeutic effectiveness, careful monitoring of antimicrobial agents and the compilation of an up-to-date list of them is necessary, based on the active substances and drug resistance of pathogens of infectious diseases. Thus, reviews of effective antibiotic therapy are a current area of veterinary medicine.
Identification of genes associated with color characteristics of meat and fat tissue of aberdeen-angus cattle
Authors: Belous A. A. , Sermyagin A. A. , Elatkin N. P. , Zinovieva N. A.
Published: June 2024

Currently, full genome association studies and identification of candidate genes for economically useful traits in farm animals are topical, scientifically sound and practice-oriented, and fulfill one of the objectives of the Strategy for Scientific and Technical Development of the Russian Federation. This article presents the results of GWAS on color spectral values of meat and fat tissue of Aberdeen-Angus cattle, known for its meat characteristics of high grade. The animals were genotyped on high-density BovineHD Genotyping BeadChip chips containing ≈53,000 SNPs. After quality control, 39,928 remained. By analysis and structural annotation, 25 and 26 candidate genes for meat and fat color were identified, respectively. According to functional annotation, the genes were categorized into 6 groups: nervous system functions, organ development, vascular, joints, metabolic processes and biosynthesis, cellular processes, muscle, tissue and bone, reproduction and embryonic development. The obtained genes were checked through the Animal QTL database, as a result of which 13 genes were confirmed, of which 3 were localized SNPs, in connection with which the LRP2, SCIN and ANTXR1 genes have advantages for their further application in the molecular diagnostics of cattle not only meat, but also dairy productivity.
The influence of pre-sowing treatment of seeds with molybdenum on the yield of pea grain in the conditions of the Republic of Bashkortostan
Authors: Davletov F. A. , Gainullina K. P. , Badamshina E. V. , Yuldybayev I. R.
Published: June 2024

Relevance. Molybdenum is an essential micronutrient element necessary for plant growth and development. In addition to the fact that molybdenum is part of hormones and enzymes, in legumes it improves nitrogen fixation and nitrogen nutrition, increases the efficiency of phosphorus-potassium fertilizers, thereby increasing productivity.

The purpose of this work is to assess the effect of pre–sowing seed treatment with various doses of molybdenum on the yield of pea grain.

The experiments were carried out in 2019–2023 in the conditions of the Cis-Ural steppe of the Republic of Bashkortostan. The material for the study was the pea cultivar Pamyati Popova.

Methods. An ammonium molybdate solution at a dose of 10, 25, 40, 55 g of molybdenum per 1 kg of seeds was used for pre-sowing treatment. Phenological observations, determination of the completeness of germination and plant height, analysis of the yield structure were carried out in accordance with the methodology of the state cultivar testing of agricultural crops.

Results. It was found that pre-sowing treatment of pea seeds of the cultivar Pamyati Popova with molybdenum at a dose of 40 and 55 g/c compared to the control resulted in a reliable (p ≤ 0.05) increase in field germination, safety of plants for harvesting, the number of nodules on 10 plants and their weight. As a result of processing pea seeds with molybdenum at doses of 25, 40 and 55 g/c, the number of beans per plant increased by 5.7–11.4%, the number of seeds per plant – by 13.2–19.5%, grain yield – by 7.3–10.7% compared with the control. Thus, in our experiments, pre-sowing treatment of seeds with molybdenum at a dose of 25–40 g/c was optimal for increasing the value of pea grain yield.
МОДЕРНІЗАЦІЯ НАВЧАЛЬНОГО ПРОЦЕСУ У ВНЗ В УМОВАХ РЕАЛІЗАЦІЇ ТЕХНОЛОГІЇ МЕРЕЖЕВОГО НАВЧАННЯ
Authors: ЛЕЙ Чжан
Published: June 2024

У статті показано, що соціальна трансформація, яку переживає сучасне суспільство, викликає необхідність її модернізації. У процесі модернізації суспільства велику роль відіграє модернізація вищої освіти. Інструментом модернізації вищої освіти в епоху Четвертої промислової революції має стати його цифровізація. Автор ставили собі завдання з урахуванням соціально-філософського аналізу виявити сутність, основні напрями, протиріччя та ризики цифровізації освітнього процесу у сучасному вузі. У ході теоретичного аналізу розкрито суть мережевого навчання, встановлено перелік значимих у розвиток суспільства цифрових технологій. У зв’язку з цим перед вищою освітою постають грандіозні завдання, що вимагають його радикальної трансформації, надання йому яскраво вираженої інноваційної спрямованості. Проблема мережевого навчання у ВНЗ розглядається нами у контексті компетентнісного підходу, який нині є базовим для вищої професійної освіти в Україні. Цей підхід передбачає як формування системних знань учнів, а й розвиток у них ключові навички та особистісні характеристики, необхідні для професійної діяльності. У цьому важливі як конкретні практичні вміння, і soft skills (укр. «гнучкі навички», «м’які навички»), роль яких у підготовці фахівців зростає. Мета статті – розкрити сутність та особливості модернізації навчального процесу у ВНЗ в умовах реалізації технології мережевого навчання. Методологія дослідження: аналіз науково-методичної літератури, узагальнення передового досвіду використання технологій мережевого навчання у ВНЗ. У статті обґрунтовано актуальність модернізації навчального процесу у ВНЗ з використанням технологій мережевого навчання. Розкрито сутність та особливості мережевого навчання, його переваги та недоліки. Визначено шляхи та перспективи впровадження технології мережевого навчання у ВНЗ. Наукова новизна: у статті запропоновано новий підхід до модернізації навчального процесу у ВНЗ на основі використання технології мережевого навчання.
Bioethics
and Geopolitics - The War in Ukraine as Cause
Authors: Skalovski Denko
Published: June 2024

The article mainly relies on original scientific papers, and reviews of a large number of bioethical works published from the end of the last century to the present day, but it primarily leans on the reviews, critical reflections and comments of the renowned Croatian philosopher Rade Kalanj. He rightfully warned some thirty years ago that biological and genetic research had reached a level ("a borderline situation"/Jaspers) where the question of the relationship between science and ethics is raised anew, but now in a much sharper and more radical form. Today, in light of the war in Ukraine, we would add: the relationship between bioethics and geopolitics. One of the severe consequences of the tragic events in Ukraine is the danger of exacerbating the already significant global hunger, in which, ultimately, it becomes less important whether food is natural/organic or GMO, but rather whether there is any food at all, primarily the grains. Or, on the contrary, there is an abundance of food, but only for those who have money to buy it, and their numbers are decreasing, so it remains to give them food. But in that case, the profits of global capitalism would be missing, which would certainly be unacceptable for the world's transnational elites and practically endanger the foundations of capitalism, marking the end of the global capitalist system/order. So, a major humanitarian catastrophe is looming, supplemented by millions of refugees, not only from Ukraine but also from around the world. This situation will be exacerbated by poor economic consequences, primarily for the EU and then for the whole world, all of which includes the UN and its specialised agencies, primarily UNHCR and UNESCO, in solving serious international problems, which certainly includes the issue of (un)acceptability of bioethical axioms for all civilisations and cultures. Among other things, the question arises as to who will be responsible/blamed for the global humanitarian catastrophe regarding the war in Ukraine: whether, as before, only Russia, or whether the list of accused will be expanded to include "Third World" countries, primarily China and Iran? Ahead of us lies a spectrum of bioethical questions, moral dilemmas, and temptations, especially when the existence of experimental biomedical laboratories on the territory of western Ukraine is revealed, reminiscent of the horrors of Nazi biomedical experiments in World War II.
Lace in Croatia – Tradition and Sustainable Development
Authors: Vekić Tonka , Bogut Irella
Published: June 2024

On the UNESCO list of intangible cultural heritage in Croatia, art has taken its place, respectively the skill of textile handicrafts, better known as lacemaking, which rests on preservation, promotion and sustainability tradition. Consequently, sustainable development is based on an integrated, comprehensive approach to economic, ecological and social values through the natural, social and human sciences. Interweaving threads using a needle or a stick forms a characteristic shape of textile activity that requires exceptional calmness, patience, precision and specific work of hands whose product is a handicraft called lace. This work aims to explore and compare the role and purpose of Croatian lace in the past and today to raise awareness of tradition and the value that Croatian lace still carries today. The lace tradition in Croatia has been nurtured for centuries, especially in smaller rural areas where women have woven their traces in the rich history of folk art by making lace. Silk, cotton, linen, silver and gold threads form a hollow work worthy of admiration. With their technological and artistic characteristics, lace works are not only an integral part of the culture of the community but also an indicator of artistic creativity in Croatia.
Vents contraires. Le Parti socialiste suisse face aux crises économiques et à l’essor du néolibéralisme (1973-1995)
Authors: Buclin Hadrien
Published: June 2024

Le 12 février 1984, c’est dans une ambiance survoltée, après 11 heures de débat, que les délégué·es au congrès du Parti socialiste suisse (PSS) décident que leurs représentant·es continueront de siéger au Conseil fédéral. Ce choix constitue une défaite pour l’aile gauche du PSS, car celle-ci réclamait un retour à l’opposition après que la candidate socialiste pour l’élection au gouvernement a été évincée par la majorité de droite. Cet épisode illustre parfaitement les difficultés rencontrées à partir du milieu des années 1970 par la principale force politique de gauche du pays. Sur fond de crises économiques à répétition et d’essor des politiques néolibérales sur le plan international, le PSS se heurte à des adversaires de moins en moins enclins au compromis. Ce climat politique plus dur remet en cause la conquête graduelle des progrès sociaux visée par le parti dans la période d’après-guerre. Le présent ouvrage examine les débats et tensions traversés par le PSS et comment ce dernier a bravé de nombreux vents contraires entre 1973 et 1995. L’auteur y montre que les dirigeant·es socialistes ont dû user d’un art de la synthèse permanent pour que tiennent ensemble des sensibilités politiques divergentes, entre partisan·es d’une adaptation accrue à la mondialisation libérale et défenseur·es d’un État social fort et interventionniste. À travers l’étude d’un parti gouvernemental, ce texte invite à une plongée dans plus de deux décennies de politique fédérale, en revisitant les enjeux qui ont marqué la Suisse contemporaine, du système de retraites à la construction européenne en passant par l’empreinte des mouvements sociaux sur la vie politique.
Pouvoir et emprise du sport. Pour une histoire croisée du tourisme et du sport depuis le XIXe siècle
Authors: Mayencourt Gil , Cala Sébastien , Amacher Hoppler Anna , Hauser Claude
Published: June 2024

Des pionniers anglais du ski alpin dans l’Oberland bernois aux touristes avant-gardistes arpentant les routes d’Europe à bicyclette ; des premiers téléphériques sur les sommets d’Engadine aux débuts des politiques de loisirs sportifs et d’aménagement du territoire à des fins touristiques ; des collines québécoises aux bords de mer du Finistère : pratiqués à pied, à ski, à vélo ou en automobile, sport et tourisme se croisent et se rencontrent au fil de deux siècles d’histoire. À partir des années 1850, ces deux phénomènes sociaux, culturels et économiques connaissent un essor significatif sous l’action d’acteurs individuels et collectifs : du sportsman à l’hôtelier, ce livre relate leur histoire, sans négliger le rôle d’autres types de promoteurs qui prennent pour habitude de se réunir en association afin de fédérer leurs intérêts. Regroupant des contributions issues d’un panel international de chercheuses et de chercheurs, parmi lesquel·le·s figurent les plus grand·e·s spécialistes de l’histoire du tourisme en Suisse et en Europe, cet ouvrage vise à mettre en perspective la complexité et le caractère souvent paradoxal du couple « sport et tourisme », à l’heure où l’urgence climatique appelle à repenser leurs modèles traditionnels de fonctionnement. Les réflexions développées au fil des pages cherchent ainsi à répondre aux questions suivantes : historiquement, qu’est-ce que le sport apporte au développement du tourisme ? Quelle est la place des milieux touristiques dans les processus d’institutionnalisation et de sportivisation des exercices physiques ? Comment le sport et le tourisme revendiquent-ils leur autonomie propre au sein d’un système où la réciprocité et la superposition des enjeux politiques, socioéconomiques et environnementaux deviennent rapidement la norme ?
Tác động của bất ổn chính sách kinh tế thế giới tới rủi ro sụp đổ giá trên thị trường chứng khoán Việt Nam
Authors: Lê Hải Trung , Nguyễn Thanh Tùng
Published: June 2024

Nghiên cứu này đánh giá tác động của bất ổn chính sách kinh tế thế giới tới rủi ro sụt giảm giá cổ phiếu niêm yết trên thị trường chứng khoán Việt Nam. Cụ thể, nghiên cứu đánh giá tác động của chỉ số bất ổn chính sách kinh tế thế giới GEPU (Global Economic Policy Uncertainty) tới rủi ro sụp đổ giá của 214 cổ phiếu niêm yết trên thị trường chứng khoán Việt Nam từ 2013 tới 2022. Kết quả hồi quy dữ liệu bảng cho thấy tác động cùng chiều của mức độ bất ổn chính sách kinh tế đối với rủi ro sụp đổ giá cổ phiếu. Đồng thời tác động này cũng mạnh hơn ở các cổ phiếu có quy mô giao dịch lớn, thể hiện mức độ bất đồng ý kiến lớn hơn trong đánh giá cổ phiếu của các nhà đầu tư. Bên cạnh đó, khi so sánh tác động của hai quốc gia là đối tác thương mại lớn nhất của Việt Nam là Mỹ và Trung Quốc, kết quả cho thấy rủi ro sụp đổ giá cổ phiếu chủ yếu chịu tác động lớn hơn từ bất ổn chính sách kinh tế tại Mỹ. Các kết quả này thể hiện đặc điểm của thị trường chứng khoán Việt Nam với tỷ lệ nhà đầu tư cá nhân cao, dẫn đến phản ứng mạnh mẽ hơn với các cú sốc của thế giới do hiệu ứng tâm lý của nhà đầu tư cá nhân.
Membangun Budaya Sadar Bencana melalui Komunikasi Mitigasi pada Masyarakat Desa Cijengkol, Subang, Jawa Barat
Authors: Imaddudin Imaddudin , Nurhaliza Wa Ode Sitti , Suciati Titis Nurwulan , Iman Asrul Nur , Widodo Aan , Hidayanto Syahrul , Athalarik Fadli M.
Published: June 2024

Kewaspadaan akan bencana menjadi perhatian setiap individu, tak luput dengan Masyarakat Desa Cijengkol, Subang Jawa Barat. Bencana bisa terjadi kapan saja menimpa dan mengganggu kehidupan masyarakat. Kesiapsiagaan tersebut dikomunikasikan agar mitigasi semua elemen masyarakat untuk memahami dan mengimplementasikan. Melalui penyuluhan dalam bentuk informasi dan edukasi diharapkan membangun budaya sadar bencana baik alam, non alam, maupun sosial. Metodenya dilakukan diskusi awal permasalahan hingga penyuluhan dan evaluasi. Melalui dua tahapan yaitu penyuluhan mengenai gambaran umum akan mitigasi bencana serta tahapan kedua membangun manajemen emosional agar terbentuknya sadar bencana yang masif pada masyarakat. Hasilnya Masyarakat Desa Cijengkol, Subang Jawa Barat secara kognitif mampu memahami bencana dan jenisnya, dan menjadi perhatian untuk diantisipasi bersama. Sedangkan secara afektif dan konatif, belum mengikat sepenuhnya, yang seharusnya elemen masyarakat juga sebagai penyelamat bukan ingin diselamatkan sebagai mindset utama. Sehingga terbentuknya budaya sadar bencana  bukan hanya bagi kalangan pemerintahan saja melainkan seluruh elemen masyarakat untuk diimplementasikan setiap harinya.
Adventures in ageing: the gender-ageing nexus and older North American women’s engagement with communities of care through lifestyle migration
Authors: Hayes Matthew , Allain Kristi
Published: June 2024

Drawing from ethnographic research and interviews with older North American women who migrated alone to retire in Ecuador, this article grows the body of literature on gender and ageing, examining how these women position themselves within a gender-ageing nexus, contradicting certain gender norms in their attempt to obtain later-life self-fulfilment. Particularly, we examine how this group positions the third age as a time of individual adventure and self-actualisation, challenging normative gender ideals about femininity and care but meeting (many) social expectations to “age well.” We argue that the lifestyles of these women demonstrate new experiments with gendered ageing, facilitated by global inequalities but challenging some normative ideals around femininity and old(er) age.
Knowledge And Awareness Towards Infant Oral Health Among Medical And Nursing Undergraduates In Salem – A Quesstionaire Study
Authors: Arali Veena , S. Abinaya
Published: June 2024

Aim
This study was intended to evaluate the knowledge and awareness towards infant oral health care among medical and nursing undergraduates in Salem , Tamil Nadu.

Material And Methods
A study was conducted among medical and nursing undergraduates in Salem. A self administered 22 questionnaire regarding knowledge and awareness towards infant oral health care was administered among medical and nursing undergraduate students in Salem. In this regard, a preliminary study with a convenience sample of 201 medical and 199 nursing students was conducted so as to assess the knowledge of infant oral health care among graduating medical and nursing students in Salem, Tamil Nadu.

Results
In this study the nursing students had better knowledge and awareness of infant oral health care as compared to medical students.

Conclusion
As the nurses along with the medical professionals interact quite frequently with the parents and children at very young age they might be beneficial in imparting oral health education, there by reducing the burden of dental problems in growing children.

Key Words
Infant oral health care ,medical graduates, nursing graduates ,dental problems, oral habits
Assessment of Awareness and Practices about Oral Hygiene among General
Public of Nagpur City- A Cross Sectional Survey
Authors: Akre Rishita , Kahar Anita , Joshi Jayashree
Published: June 2024

Introduction
Oral cavity is the gateway of our body. So for a health body one’s oral cavity should be healthy. Many researchers have proven the fact that unhealthy oral cavity is the cause of many systemic diseases. It is a common observation which came to notice that many people neglect their oral hygiene because of the insufficient knowledge about oral hygiene maintenance. So, being a dental professional it is our prime duty to make aware the people about their oral hygiene and spread the oral health education and awareness about is maintenance among the society. So the present study was designed among the general public of Nagpur city.

Aim & Objective
To assess the awareness and practices about oral hygiene among general public of Nagpur city accordng to their age, gender and educational status.

Material and Methods
A cross sectional survey was conducted among the general public of Nagpur city. A pre-validated eleven item questionnaire was distributed among the general public for a period of one month.

Results
Out of a study population of 400, 202 (50.5%) of them brush their teeth for 1 to 3 minutes, while 205 (51.25%) follow vertical and horizontal types of brushing. About 184 (46%) were unaware of secondary methods of oral hygiene maintenance and, 320 (80%) of them are unaware about connection between oral and systemic health.

Conclusion
The overall awareness and practices about oral hygiene among the present study population was satisfactory. However, there is a need to increase the awareness about periodic dental visit and relationship between systemic health and oral cavity.

Key Words
Awareness, practices, General public, Nagpur city, Oral hygiene
Development of bioluminescent reporter Trypanosoma cruzi and bioassay for compound screening
Authors: Quiroga Cristina , Incerti Marcelo , Benitez Diego , Manta Eduardo , Medeiros Andrea , Comini Marcelo A.
Published: June 2024

Trypanosoma cruzi is the etiologic agent of Chagas’ disease, a debilitating and mortal zoonotic illness that threatens the lives of several millions of people in the American continent. The acute phase is underdiagnosed and there is no curative treatment for the chronic stage. This unicellular pathogen colonizes cells from different tissues wherein it replicates and remains hidden from immune recognition. There is an urgent need to develop new chemotherapy, which requires robust screening bioassays against the amastigote, a proliferative and drug-resilient intracellular stage of the parasite. With this aim, here we present the generation and characterization of a bioluminescent reporter cell line of the highly infective strain Dm28c from T. cruzi. Constitutive and stable expression of the reporter gene (a red-shifted luciferase from Photinus pyralis) was achieved in the different developmental stages of the pathogen. The transgene did not affect parasite growth and differentiation. The bioluminescence signal displayed a linear correlation with the parasite number. A 96-well screening assay against the amastigote stage has been established and validated with a small compound library. The bioassay proved sensitive, robust, and amenable for high throughput applications. The reporter cell line may prove highly valuable to address different goals in the early phase of the drug discovery process against American trypanosomiasis.
Deformation and collapse of rock slopes considering weak plane orientation
Authors: Chang Kuang-Tsung , Yeh Po-Tsun , Hsiao Yu-Shen , Wang Chao-Yu , Chiu Ya-Chu
Published: June 2024

Some slopes experience multiple slides without collapse, while other slopes collapse once they are unstable. The early warning of slope collapse is a difficult but important subject. Considering the influence of weak planes on rock slope deformation and collapse is helpful for interpreting the behavior of deep-seated landslides and designing an early warning system. To investigate the deformation behavior of rock slopes with consideration on weak planes, artificial cemented sand plates were produced and stacked to form physical slope models with different weak plane orientations, where inclined loading was applied to induce the deformation and collapse of the slope. In addition, the deformation of real slopes was examined based on topographic features. The average strain at collapse is referred to as the critical strain, whose value changes for various slopes. Sorted by critical strain in descending order, the slope models include an anaclinal slope with 60° weak planes, an anaclinal slope with 30° weak planes, a cataclinal slope where the 30° weak planes coincide with the slope face, and a cataclinal slope with daylighting 20° weak planes. Similar to the experimental results, anaclinal slopes also present greater average strain values than cataclinal slopes for real slopes. A smaller critical strain implies a higher possibility for slope collapse when unstable. Local deformation does not always lead to collapse, but as the average velocity and the average strain rate of the sliding body increase, or the velocity ratio (VR) between the upper and lower parts of the sliding body approaches 1, a sliding surface inside the slope is likely developing and coalescing. Hence, such deformation features may contribute to a landslide warning system.
Deep learning for geological mapping in the overburden area
Authors: Liu Yao , Cheng Jianyuan , Lü Qingtian , Liu Zaibin , Lu Jingjin , Fan Zhenyu , Zhang Lianzhi
Published: June 2024

This paper aims to achieve bedrock geologic mapping in the overburden area using big data, distributed computing, and deep learning techniques. First, the satellite Bouguer gravity anomaly with a resolution of 2′×2′ in the range of E66°-E96°, N40°-N55° and 1:5000000 Asia-European geological map are used to design a dataset for bedrock prediction. Then, starting from the gravity anomaly formula in the spherical coordinate system, we deduce the non-linear functional between rock density ρ and rock mineral composition m, content p, buried depth h, diagenesis time t and other variables. We analyze the feasibility of using deep neural network to approximate the above nonlinear generalization. The problem of solving deep neural network parameters is transformed into a non-convex optimization problem. We give an iterative, gradient descent-based solution algorithm for the non-convex optimization problem. Utilizing neural architecture search (NAS) and human-designed approach, we propose a geological-geophysical mapping network (GGMNet). The dataset for the network consists of both gravity anomaly and a priori geological information. The network has fast convergence speed and stable iteration during the training process. It also has better performance than a single neural network search or human-designed architectures, with the mean pixel accuracy (MAP) = 63.1% and the frequency weighted intersection over union (FWIoU) = 42.88. Finally, the GGMNet is used to predict the rock distribution of the Junggar Basin.
The mind of a maker: a learning framework for a continuum of K-12 invention education
Authors: Scharon Catherine J. , Phillips Annalise , Jones-Davis Dorothy
Published: June 2024

Invention education offers an exciting combination of knowledge and skill-based learning that is intertwined with important social and emotional competencies, especially for youth engaged in structured programs. KID Museum in Bethesda, Maryland, is an experiential museum and K-12 makerspace whose offerings include a suite of invention programs implemented through formal curricula, field trips, and out-of-school time opportunities. KID Museum’s Mind of a Maker learning framework is a promising pedagogical model for conceptualizing the broad range of learning outcomes targeted in these programs. By comparing to other frameworks developed separately but concurrently, the Mind of a Maker offers insights into the underlying values and learning theories that shape invention education and can contribute to a field-wide understanding of this area of experiential learning. This article explores constructs that promote an inventive mindset that may be reproducible in other learning contexts, as well as the ways in which framework outcomes are integrated into the design, reach, and evaluation of KID Museum’s invention programs.
Shaping the foundation of the SuperCyberKids Learning Framework: a comprehensive analysis of cybersecurity education initiatives
Authors: Manganello Flavio , Earp Jeffrey , Fante Chiara , Bassi Giorgia , Fabbri Stefania , Matteucci Ilaria , Vaccarelli Anna , Olesen Nina , de Vibraye Arnaud , Callaghan Peadar , Gentile Manuel
Published: June 2024

In the rapidly evolving digital landscape, cybersecurity education for children is paramount. The SuperCyberKids project, funded under the EU Erasmus+ programme, aims to address this need by developing a comprehensive educational ecosystem for children aged 8 to 13 and their teachers. Central to this initiative is the SuperCyberKids Learning Framework (SCKLF), which incorporates a game-based approach to enhance engagement and motivation through a bespoke digital learning platform and broader ecosystem. This paper focuses on the second pillar of SCKLF, a detailed survey of 65 cybersecurity education initiatives, offering a practical perspective on the current state of cybersecurity education. The survey covered initiatives within and beyond the European Union, emphasizing the target age group. The analysis of these initiatives provides invaluable insights into the practical application of cybersecurity education and played a crucial role in shaping the SCKLF. By highlighting the diversity of approaches and strategies in cybersecurity education, this research contributes to a more holistic and applied perspective, ensuring the framework’s relevance and effectiveness in fostering digital resilience among young learners.
Endoscopic ultrasonography-based intratumoral and peritumoral machine learning radiomics analyses for distinguishing insulinomas from non-functional pancreatic neuroendocrine tumors
Authors: Mo Shuangyang , Huang Cheng , Wang Yingwei , Zhao Huaying , Wu Wenhong , Jiang Haixing , Qin Shanyu
Published: June 2024

Objectives

To develop and validate radiomics models utilizing endoscopic ultrasonography (EUS) images to distinguish insulinomas from non-functional pancreatic neuroendocrine tumors (NF-PNETs).

Methods

A total of 106 patients, comprising 61 with insulinomas and 45 with NF-PNETs, were included in this study. The patients were randomly assigned to either the training or test cohort. Radiomics features were extracted from both the intratumoral and peritumoral regions, respectively. Six machine learning algorithms were utilized to train intratumoral prediction models, using only the nonzero coefficient features. The researchers identified the most effective intratumoral radiomics model and subsequently employed it to develop peritumoral and combined radiomics models. Finally, a predictive nomogram for insulinomas was constructed and assessed.

Results

A total of 107 radiomics features were extracted based on EUS, and only features with nonzero coefficients were retained. Among the six intratumoral radiomics models, the light gradient boosting machine (LightGBM) model demonstrated superior performance. Furthermore, a peritumoral radiomics model was established and evaluated. The combined model, integrating both the intratumoral and peritumoral radiomics features, exhibited a comparable performance in the training cohort (AUC=0.876) and achieved the highest accuracy in predicting outcomes in the test cohorts (AUC=0.835). The Delong test, calibration curves, and decision curve analysis (DCA) were employed to validate these findings. Insulinomas exhibited a significantly smaller diameter compared to NF-PNETs. Finally, the nomogram, incorporating diameter and radiomics signature, was constructed and assessed, which owned superior performance in both the training (AUC=0.929) and test (AUC=0.913) cohorts.

Conclusion

A novel and impactful radiomics model and nomogram were developed and validated for the accurate differentiation of NF-PNETs and insulinomas utilizing EUS images.
Case report: management of a young male patient with diabetic ketoacidosis and thyroid storm
Authors: Huang Xiaoyu , Chen Yan , Huang Xinwei , Tang Jiahao
Published: June 2024

This report describes a case of concomitant diabetic ketoacidosis (DKA) and thyroid storm (TS) in a 20-year-old male patient that presented both diagnostic and management challenges owing to their intricate interrelationship in endocrine-metabolic disorders. The patient, previously diagnosed with type 1 diabetes mellitus (T1DM) and hyperthyroidism, was admitted to the emergency department with symptoms of DKA and progressive exacerbation of TS. Initial treatment focused on correcting DKA; as the disease progressed to TS, it was promptly recognized and treated. This case emphasizes the rarity of simultaneous occurrence of DKA and TS, as well as the challenges in clinical diagnosis posed by the interacting pathophysiological processes and overlapping clinical manifestations of DKA and TS. The patient’s treatment process involved multiple disciplines, and after treatment, the patient’s critical condition of both endocrine metabolic diseases was alleviated, after which he recovered and was eventually discharged from the hospital. This case report aims to emphasize the need for heightened awareness in patients with complex clinical presentations, stress the possibility of concurrent complications, and underscore the importance of prompt and collaborative treatment strategies.
Insulin resistance in the retina: possible implications for certain ocular diseases
Authors: Zheng Zhaoxia , Yu Xiaobing
Published: June 2024

Insulin resistance (IR) is becoming a worldwide medical and public health challenge as an increasing prevalence of obesity and metabolic disorders. Accumulated evidence has demonstrated a strong relationship between IR and a higher incidence of several dramatically vision-threatening retinal diseases, including diabetic retinopathy, age-related macular degeneration, and glaucoma. In this review, we provide a schematic overview of the associations between IR and certain ocular diseases and further explore the possible mechanisms. Although the exact causes explaining these associations have not been fully elucidated, underlying mechanisms of oxidative stress, chronic low-grade inflammation, endothelial dysfunction and vasoconstriction, and neurodegenerative impairments may be involved. Given that IR is a modifiable risk factor, it may be important to identify patients at a high IR level with prompt treatment, which may decrease the risk of developing certain ocular diseases. Additionally, improving IR through the activation of insulin signaling pathways could become a potential therapeutic target.