bluuebunny/crossref_metadata_2025 huggingface dataset:
Perioperative active warming strategies in children: a protocol for a multicentre, prospective, randomized controlled trial
Authors: Qiao Lanxin , Wang Yaxin , Liang Yi , Xia Tian , Li Ling , Xiong Wei , Liu Bin , Feng Yifan , Liu Yan , Jin Xu , Zhang Jianmin
Published: June 2023

Introduction

Inadvertent perioperative hypothermia (IPH) refers to a core body temperature lower than 36.0 °C, which can contribute to many adverse events. The special physiological characteristics in children further increase the incidence of IPH. Therefore, it is very important to perform effective perioperative warming measures for children. Traditional passive warming measures with additional layers have limited thermal insulation effects. Active warming measures might be the better choice, and most measures have achieved good effects in adults. This study combines a variety of active warming measures to propose perioperative active warming strategies and aims to verify the feasibility and thermal insulation effects of perioperative active warming strategies in children.

Methods

This study is a multicentre, prospective, randomized controlled trial. From August 2022 to July 2024, 400 paediatric patients undergoing elective surgery will be recruited in four centres and randomly divided into the active warming strategies group and control group at a ratio of 1:1. The primary outcome is the perioperative cumulative hypothermia effect value (Σ ΔTi × Δti, i = 1…, n). Multiple complications covering the anaesthesia recovery period and postoperative hospitalization will be considered as secondary outcomes to comprehensively analyse the prognosis.

Trial registration

ClinicalTrials.gov identifier: ChiCTR2200062168. Registered on July 26th, 2022. Registered with the name of “Perioperative Active Warming Strategies in Children: A multicenter, prospective, randomized controlled trial”. URL:http://www.chictr.org.cn/showproj.aspx?proj=172778.
Robot-assisted resection of choledochal cyst in children
Authors: Jin Yi , Zhang Shuhao , Cai Duote , Zhang Yuebin , Luo Wenjuan , Chen Ken , Chen Qingjiang , Gao Zhigang
Published: June 2023

Background

The emergence of the robotic surgery system has assisted the further development of minimally invasive surgery by facilitating more delicate and precise complex procedures. The purpose of this study was to present a study of robot-assisted resection of the choledochal cyst and to discuss the technical points.

Methods

In total, 133 patients who were diagnosed with a choledochal cyst and underwent surgery from April 2020 to February 2022 in the Children's Hospital, Zhejiang University School of Medicine, were retrospectively analyzed. The data were collected including the clinical information of the patients, operative details, and postoperative outcomes.

Results

Among these 133 patients, 99 underwent robot-assisted surgery and 34 underwent laparoscopic assisted surgery. The median operation time was 180 min, with an interquartile range (IQR) of 170–210 min for the robot-assisted group and 180 min with an IQR of 157.5–220 min in the laparoscopic assisted group (P = 0.290). The detection rate of 82.5% for the distal opening of the cystic type of choledochal cyst was higher in the robot-assisted group than that in the laparoscopic assisted group at 34.8% (P = 0.000). The postoperative hospital stay was shorter (P = 0.009) and the hospitalization expense was higher (P = 0.000) in the robot-assisted group than that of the laparoscopic assisted group. There was no significant difference between the two groups in terms of complications, postoperative indwelling days of the abdominal drainage tube, intraoperative blood loss, and postoperative fasting time (P > 0.05).

Conclusions

Robot-assisted resection of choledochal cyst is safe and feasible, it is ideal for the patient requiring a meticulous operation, and its postoperative recovery was shorter than for traditional laparoscopy.
Phosphoproteomic and proteomic profiling in post-infarction chronic heart failure
Authors: Wang Jiayue , Zhu Xiuhua , Wang Shenrui , Zhang Yingjie , Hua Wenjie , Liu Zhenyu , Zheng Yu , Lu Xiao
Published: June 2023

Background: Post-infarction chronic heart failure is the most common type of heart failure. Patients with chronic heart failure show elevated morbidity and mortality with limited evidence-based therapies. Phosphoproteomic and proteomic analysis can provide insights regarding molecular mechanisms underlying post-infarction chronic heart failure and explore new therapeutic approaches.

Methods and results: Global quantitative phosphoproteomic and proteomic analysis of left ventricular tissues from post-infarction chronic heart failure rats were performed. A total of 33 differentially expressed phosphorylated proteins (DPPs) and 129 differentially expressed proteins were identified. Bioinformatic analysis indicated that DPPs were enriched mostly in nucleocytoplasmic transport and mRNA surveillance pathway. Bclaf1 Ser658 was identified after construction of Protein-Protein Interaction Network and intersection with Thanatos Apoptosis Database. Predicted Upstream Kinases of DPPs based on kinase-substrate enrichment analysis (KSEA) app showed 13 kinases enhanced in heart failure. Proteomic analysis showed marked changes in protein expression related to cardiac contractility and metabolism.

Conclusion: The present study marked phosphoproteomics and proteomics changes in post-infarction chronic heart failure. Bclaf1 Ser658 might play a critical role in apoptosis in heart failure. PRKAA1, PRKACA, and PAK1 might serve as potential therapeutic targets for post-infarction chronic heart failure.
Quantitative security analysis of three-level unitary operations in quantum secret sharing without entanglement
Authors: Xu Juan , Li Xi , Han Yunguang , Zhou Yuqian , Liu Zhihao , Zhang Zhengye , Song Yinxiu
Published: June 2023

Quantum secret sharing (QSS) protocols without entanglement have showed high security by virtue of the characteristics of quantum mechanics. However, it is still a challenge to compare the security of such protocols depending on quantitative security analysis. Based on our previous security analysis work on protocols using single qubits and two-level unitary operations, QSS protocols with single qutrits and three-level unitary operations are considered in this paper. Under the Bell-state attack we propose, the quantitative security analyses according to different three-level unitary operations are provided respectively in the one-step and two-step situations. Finally, important conclusions are drawn for designing and implementing such QSS protocols. The method and results may also contribute to analyze the security of other high-level quantum cryptography schemes based on unitary operations.
Advances of herbivore-secreted elicitors and effectors in plant-insect interactions
Authors: Wang Huiying , Shi Shaojie , Hua Wei
Published: June 2023

Diverse molecular processes regulate the interactions between insect herbivores and their host plants. When plants are exposed to insects, elicitors induce plant defenses, and complex physiological and biochemical processes are triggered, such as the activation of the jasmonic acid (JA) and salicylic acid (SA) pathways, Ca2+flux, reactive oxygen species (ROS) burst, mitogen-activated protein kinase (MAPK) activation, and other responses. For better adaptation, insects secrete a large number of effectors to interfere with plant defenses on multiple levels. In plants, resistance (R) proteins have evolved to recognize effectors and trigger stronger defense responses. However, only a few effectors recognized by R proteins have been identified until now. Multi-omics approaches for high-throughput elicitor/effector identification and functional characterization have been developed. In this review, we mainly highlight the recent advances in the identification of the elicitors and effectors secreted by insects and their target proteins in plants and discuss their underlying molecular mechanisms, which will provide new inspiration for controlling these insect pests.
Characterization of endophytic bacteriome diversity and associated beneficial bacteria inhabiting a macrophyte Eichhornia crassipes
Authors: Fan Di , Schwinghamer Timothy , Liu Shuaitong , Xia Ouyuan , Ge Chunmei , Chen Qun , Smith Donald L.
Published: June 2023

Introduction

The endosphere of a plant is an interface containing a thriving community of endobacteria that can affect plant growth and potential for bioremediation. Eichhornia crassipes is an aquatic macrophyte, adapted to estuarine and freshwater ecosystems, which harbors a diverse bacterial community. Despite this, we currently lack a predictive understanding of how E. crassipes taxonomically structure the endobacterial community assemblies across distinct habitats (root, stem, and leaf).

Methods

In the present study, we assessed the endophytic bacteriome from different compartments using 16S rRNA gene sequencing analysis and verified the in vitro plant beneficial potential of isolated bacterial endophytes of E. crassipes.

Results and discussion

Plant compartments displayed a significant impact on the endobacterial community structures. Stem and leaf tissues were more selective, and the community exhibited a lower richness and diversity than root tissue. The taxonomic analysis of operational taxonomic units (OTUs) showed that the major phyla belonged to Proteobacteria and Actinobacteriota (> 80% in total). The most abundant genera in the sampled endosphere was Delftia in both stem and leaf samples. Members of the family Rhizobiaceae, such as in both stem and leaf samples. Members of the family Rhizobiaceae, such as Allorhizobium- Neorhizobium-Pararhizobium-Rhizobium were mainly associated with leaf tissue, whereas the genera Nannocystis and Nitrospira from the families Nannocystaceae and Nitrospiraceae, respectively, were statistically significantly associated with root tissue. Piscinibacter and Steroidobacter were putative keystone taxa of stem tissue. Most of the endophytic bacteria isolated from E. crassipes showed in vitro plant beneficial effects known to stimulate plant growth and induce plant resistance to stresses. This study provides new insights into the distribution and interaction of endobacteria across different compartments of E. crassipes Future study of endobacterial communities, using both culture-dependent and -independent techniques, will explore the mechanisms underlying the wide-spread adaptability of E. crassipesto various ecosystems and contribute to the development of efficient bacterial consortia for bioremediation and plant growth promotion.
Transcriptome analysis of differential sugar accumulation in the developing embryo of contrasting two Castanea mollissima cultivars
Authors: Huang Ruimin , Peng Fei , Wang Dongsheng , Cao Fei , Guo Chunlei , Yu Liyang , Zhang Jingzheng , Yang Yuedong
Published: June 2023

Chinese chestnut (Castanea mollissima) is an important nut tree species, and its embryo is rich in sugar. We combined metabolomic and transcriptomic data to analyze metabolites and genes related to sugar in two Chinese chestnut cultivars at 60, 70, 80, 90 and 100 days after flowering (DAF). The soluble sugar content of high-sugar cultivar at maturity is 1.5 times that of low-sugar cultivar. Thirty sugar metabolites were identified in embryo, with the most dominant being sucrose. Analysis of the gene expression patterns revealed that the high-sugar cultivar promoted the conversion of starch to sucrose by up-regulating genes related to starch degradation and sucrose synthesis at 90-100 DAF. It also strongly increased the enzyme activity of SUS-synthetic, which may promote sucrose synthesis. Gene co-expression network analysis showed that ABA and peroxide were related to starch decomposition during Chinese chestnut ripening. Our study analyzed the composition and molecular synthesis mechanism of sugar in Chinese chestnut embryos, and provided a new insight into the regulation pattern of high sugar accumulation in Chinese chestnut nuts.
Predictive validity of a parental questionnaire for identifying children with developmental language disorders
Authors: Auza B. Alejandra , Murata Chiharu , Peñaloza Christian
Published: June 2023

Background

The underdiagnosis of developmental language disorder (DLD) in children is a serious problem in developing countries with limited resources. It has long been noted that the concerns parents have about their children’s health and development are richly informative, and if this information can be used for diagnosis, it may provide a means to address the problem of underdiagnosis of DLD. This study aimed to quantify the utility of parental linguistic concern questions (PLCQ) on the identification of language disorders in monolingual Spanish-speaking children in Mexico. It also explored whether a combination of biological and environmental conditions questions (BECQ) might improve the performance of a screening test to identify DLD.

Methods

A total of 680 monolingual Mexican Spanish-speaking children and their parents from urban areas in Mexico participated in the study. The distribution of responses to questions about DLD concerns was compared between 185 children diagnosed with DLD and 495 control subjects, and multiple logistic regression analysis was performed to select questions with high predictivity, based on the Akaike information criterion. The diagnostic utility of the questions was assessed by receiver operating characteristic (ROC) curves, stratum-specific likelihood ratios (SSLRs), and changes in pretest and post-test probabilities of DLD. A similar procedure was used to explore whether adding BECQ would improve the diagnostic utility of questions about DLD concerns using data of 128 children.

Results

Four questions regarding parental linguistic concerns were found to be useful in identifying children with DLD. When all four concerns were present, the SSLR was 8.79, while it was only 0.27 when there were no concerns at all. The estimates of DLD probability increased from 0.12 to 0.55 at pretest and post-test. On the other hand, the BECQ did not perform as well as the PLCQ in identifying DLD, and the improvement in diagnostic performance it provided was limited to one question.

Conclusion

The parental questionnaire can be used as a screening tool to help in identifying children with DLD. The data presented in this study underscore the importance of considering linguistic parental concerns as part of the screening process. This is a realistic option to provide a solution to the current problem of underdiagnosis of DLD in Mexico.
Rethinking the eidos, genos, and diaphora of the health utility concept: a psychological perspective
Authors: Broekharst Damien S. E. , Bloem Sjaak , Groenland Edward A. G. , van Raaij W. Fred , Jeurissen Patrick P. T. , van Agthoven Michel
Published: June 2023

The notion of utility gained a strong foothold in health economics over the last decades. However, the concept of health utility has not yet been decisively or irrefutably defined and the definitions that exist often do not take into account the current state of psychological literature. This perspective paper shows that the current definition of health utility emphasizes decision-making processes, deploys personal preferences, assumes psychological egoism, and attempts to objectively and cardinally measure utility. However, these foundational axioms that underly the current definition of health utility are not necessarily in concurrence with the current state of psychological literature. Due to these perceived shortcomings of the current health utility definition, it may be beneficial to redefine the concept of health utility in accordance with the current state of psychological literature. In order to develop such a revised definition of health utility the commonly deployed formula (Eidos = Genos + Diaphora) originating from Aristotle’s metaphysics is applied. The revised definition of health utility proposed in this perspective paper alludes to health utility as ‘the subjective value, expressed in terms of perceived pain or pleasure, that is attributed to the cognitive, affective and conative experience of one’s own physical, mental and social health state, which is determined through self-reflection and interaction with significant others’. Although this revised definition does neither replace nor supersede other conceptualizations of health utility, it may serve as a refreshing avenue for further discussion and could, eventually, support policymakers and health economists in operationalizing and measuring health utility in an even more accurate and veracious manner.
Case report: An evaluation of early motor skills in an infant later diagnosed with autism
Authors: Malachowski Lauren G. , Huntley Margaret-Anne , Needham Amy Work
Published: June 2023

Researchers and clinicians are increasingly interested in understanding the etiology of autism spectrum disorder (ASD) and identifying behaviors that can provide opportunities for earlier detection and therefore earlier onset of intervention activities. One promising avenue of research lies in the early development of motor skills. The present study compares the motor and object exploration behaviors of an infant later diagnosed with ASD (T.I.) with the same skills in a control infant (C.I.). There were notable difference in fine motor skills by just 3 months of age, one of the earliest fine motor differences reported in the literature. In line with previous findings, T.I. and C.I. demonstrated different patterns of visual attention as early as 2.5 months of age. At later visits to the lab, T.I. engaged in unique problem-solving behaviors not demonstrated by the experimenter (i.e., emulation). Overall, findings suggest that infants later diagnosed with ASD may show differences in fine motor skills and visual attention to objects from the first months of life.
From kinship networks to culture of relatedness: a shift of safety nets during health pandemics in the kenyan context
Authors: Nyabundi Agnetta Adiedo
Published: June 2023

Evidence suggests that, during pandemics such as COVID-19, people with low incomes within developing countries suffered disproportionately. Households across countries differentially experienced the socio-economic impact of the pandemic. In sub-Saharan Africa, the extended family and the community have provided valuable support in crises, given that state-administered backing may not be sufficient or may differ from the family's expectations. Many studies have been conducted on community safety nets, yet little description and understanding of community safety nets has been provided. The components of the non-formal safety nets are yet to be adequately defined or evaluated for effectiveness. Traditional family and community safety nets have been under stress due to the impact of COVID-19. Many countries, including Kenya, have associated COVID-19 with an increased number of households facing social and economic crises. Families and communities got fatigued due to the extended period and the further strain the pandemic had on individuals and societies. Utilizing existing literature on the socio-economic impact of COVID-19 in Kenya and the roles and perceptions of community safety nets, this paper seeks to explain the roles and perceptions of social relationships and kinship networks as safety nets in Africa, specifically in the Kenyan context. This paper employs the concept of culture of relatedness to understand the informal safety nets in Kenya better. During the COVID-19 pandemic, individuals strengthened the previously weakened kinship structures. They addressed some of the challenges experienced within the networks through the involvement of neighbors and friends embracing the culture of relatedness. Therefore, government strategies for social support during pandemics need to design programs to strengthen the community safety nets that remained resilient throughout the health crisis.
Cost-effectiveness of Paxlovid in reducing severe COVID-19 and mortality in China
Authors: Zhang Weina , Li Lanfang , Zhou Zhen , Liu Qiao , Wang Guan , Liu Dan
Published: June 2023

Objectives

To assess the cost-effectiveness of Paxlovid in reducing severe COVID-19 and its associated morality, and to investigate the affordable price of Paxlovid in China.

Materials and methods

Using a Markov model, two interventions by Paxlovid prescription (with and without prescription) were compared in terms of COVID-19-related clinical outcomes and economic loss. COVID-related costs were collected from the societal perspective. Effectiveness data were obtained from literature. The primary outcomes were total social cost, disability adjusted life-years (DALYs) and net monetary benefit (NMB). Scenario analyses were performed to investigate the affordable price of Paxlovid in China. Deterministic sensitivity analyses (DSA) and probabilistic sensitivity analysis (PSA) were performed to verify the model robustness.

Results

Compared with the non-Paxlovid cohort, the NMBs of the Paxlovid cohort were only higher in the subgroup of patients aged over 80 years old, regardless of their vaccination status. Our scenario analysis found that, the price ceiling of Paxlovid/box for it to be cost-effective was RMB 8,993 (8,970–9,009) in those aged over 80 years old who were not vaccinated, which is the highest; and was RMB 35 (27–45) in those aged 40–59 years old who were vaccinated, which is the lowest. Sensitivity analyses found that the incremental NMB for the vaccinated people aged over 80 years was most sensitive to the efficacy of Paxlovid and the cost-effectiveness probability of Paxlovid increased with its decreasing price.

Conclusion

Under the current marketing price of Paxlovid/box (RMB 1,890), using Paxlovid was only cost-effective in people aged over 80 years old regardless of their vaccination status.
Dissolution rate variability at carbonate surfaces: 4D X-ray micro-tomography and stochastic modeling investigations
Authors: Guren Marthe Grønlie , Renard François , Noiriel Catherine
Published: June 2023

We provide a detailed 3D characterization of the geometry evolution and dissolution rate mapping at the surface of four carbonate samples, namely a calcite spar crystal, two limestone rock fragments, and an aragonite ooid, using time-lapse X-ray micro-tomography during dissolution experiments at pH 4.0. Evaluation of the retreat and mapping of the reaction rates at the whole surface of the samples reveals a large spatial variability in the dissolution rates, reflecting the composition and the specific contributions of the different regions of the samples. While crystal edges and convex topographies record the highest dissolution rates, the retreat is slower for flat surfaces and in topographic lows (i.e., concave areas), suggesting surface-energy related and/or diffusion-limited reactions. Microcrystalline aragonite has the highest rate of dissolution compared to calcite. Surprisingly, rough microcrystalline calcite surface dissolves globally more slowly than the {101̄4} faces of the calcite spar crystal. The presence of mineral impurities in rocks, through the development of a rough interface that may affect the transport of species across the surface, may explain the slight decrease in reactivity with time. Finally, a macroscopic stochastic model using the set of detachment probabilities at corner, edge, and face (terrace) sites obtained from kinetic Monte Carlo simulations is applied at the spar crystal scale to account for the effect of site coordination onto reactivity. Application of the model to the three other carbonate samples is discussed regarding their geometry and composition. The results suggest that the global dissolution process of carbonate rocks does not reflect only the individual behavior of their forming minerals, but also the geometry of the crystals and the shape of the fluid-mineral interface.
Testing hypotheses about the harm that capitalism causes to the mind and brain: a theoretical framework for neuroscience research
Authors: Kokorikou Danae S. , Sarigiannidis Ioannis , Fiore Vincenzo G. , Parkin Beth , Hopkins Alexandra , El-Deredy Wael , Dilley Laura , Moutoussis Michael
Published: June 2023

In this paper, we will attempt to outline the key ideas of a theoretical framework for neuroscience research that reflects critically on the neoliberal capitalist context. We argue that neuroscience can and should illuminate the effects of neoliberal capitalism on the brains and minds of the population living under such socioeconomic systems. Firstly, we review the available empirical research indicating that the socio-economic environment is harmful to minds and brains. We, then, describe the effects of the capitalist context on neuroscience itself by presenting how it has been influenced historically. In order to set out a theoretical framework that can generate neuroscientific hypotheses with regards to the effects of the capitalist context on brains and minds, we suggest a categorization of the effects, namely deprivation, isolation and intersectional effects. We also argue in favor of a neurodiversity perspective [as opposed to the dominant model of conceptualizing neural (mal-)functioning] and for a perspective that takes into account brain plasticity and potential for change and adaptation. Lastly, we discuss the specific needs for future research as well as a frame for post-capitalist research.
Accountability and interactional inequality: the management of problems of interaction as a matter of cultural ideals and ideologies
Authors: Stevanovic Melisa
Published: June 2023

In the existing sociological literature, the notion of accountability is seen both as a tool of sense-making (intelligibility side of accountability) and as a way of maintaining larger social order (normativity side of accountability). This paper points to drastically different ways of treating an interactional violation, depending on the precise framework within which the accountabilities associated with the violation are interpreted. The normative side of accountability involves the idea of interactional inequality—that is, the notion that people are not equally held accountable for their interactional violations. I suggest that such inequalities are strengthened by the prevailing cultural ideals and ideologies of interaction according to which a competent participant can solve interactional problems as they emerge. Problems of interaction are therefore commonly let pass, and if addressed, likely to be interpreted within the framework of intelligibility. This means that the violators are likely to get away from being held accountable in the normative sense of the term. As a result, I argue, many interactional problems are commonly beyond effective intervention. In its focus on the intelligibility side of accountability CA has, not only trouble addressing interactional inequalities, but it may also inherently undermine the severity of the inequalities to be addressed. A more critical, socially and societally relevant CA would thus benefit from a more explicit engagement with the normative side of the notion.
Az online eszközök használatának hatása a tudatos szájápolási szokások kialakítására fiatal felnőtt korban
Authors: Fehér Anetta , Biró Edit Magdolna
Published: June 2023

Bevezetés: Az online eszközök számos lehetőséget nyújtanak az orális egészségfejlesztés területén. Az előre elkészítettvideók és emlékeztető üzenetek fontos kiegészítő eszközei lehetnek a kezeléseknek. A fiatal felnőttek szájhigiénésismereteinek, szokásainak és önhatékonyságának felmérését és fejlesztését céloztuk meg kísérleti és kontrollcsoportos,6 hetes longitudinális vizsgálatunk keretében.Páciensek és módszer: Saját fejlesztésű kérdőívek segítségével mértük fel a résztvevők Orálhigiénés Szokásait (OSz),Dentális Edukáltságát (DE) és Önhatékonyságát (ÖH) az első adatfelvételkor (T0). Ezt követően a résztvevők azonnalmegtekintettek egy informáló videót, majd a DE ismételt kitöltése történt (T1). A résztvevők véletlenszerű csoportba sorolásátkövetően csak a kísérleti csoport tagjai kaptak e-mail-üzeneteket heti 2 alkalommal, melyek videórészleteket ésinfógrafikákat tartalmaztak. Az utolsó adatfelvételkor (T2) történt meg mindkét csoport ismételt felmérése az OSz, DEés ÖH skálák alkalmazásával.Eredmények: 50 fő töltötte ki a kérdőíveket a T2 időpontban is, 27 fő a kontroll-, 23 fő a kísérleti csoport tagjaként.A DE szignifikáns javulást mutatott a kontroll- és kísérleti csoportban egyaránt T0–T1 (p < 0,001; p = 0,002) és T0–T2(p < 0,001; p < 0,001) időpontok összehasonlításakor, azonban egyik csoportban sem volt jelentős a T1 és T2 időpontokközötti különbség, továbbá a csoportok között sincs szignifikáns eltérés a T2 időpontban. Az OSz esetében csaka kísérleti csoportban mérhető szignifikáns különbség a T0 és T2 időpontok között (p = 0,010), akár csak az ÖH esetében(p = 0,028).Megbeszélés: Eredményeink azt igazolják, hogy a tudásszint javulásához elegendő lehet egy tájékoztatási alkalomis, azonban az orálhigiénés szokások megváltoztatása és az önhatékonyság növelése érdekében fontos az ismételt információátadás,cselekvésre motiválás, melynek hatékony formája lehet egy komplex videóanyag.
Hallássérült páciens teljes szájüregi rehabilitációja
Authors: König János , Déri Tamás Zoltán , Hermann Péter
Published: June 2023

Magyarországon egyes felmérések szerint 60 000 hallássérült ember él. Fogorvosi ellátásuk a halláskárosodás mértékétőlés típusától függően nehézségekbe ütközhet. A fogorvos feladata a kommunikáció zavartalanságáról megbizonyosodniegyenes és érthető beszéddel, a szájról olvashatóság biztosításával és esetenként jelnyelvi tolmács vagyírásban történő kommunikáció segítségével. A páciensnek ilyen esetekben is joga van a fogorvosi kezelésbe tájékozottbeleegyezést adni. Egy hallássérült páciens teljes szájüregi rehabilitációjának bemutatásával igyekszünk betekintéstnyújtani az ellátás nehézségeibe.
Joint Deployment Optimization of Parallelized SFCs and BVNFs in Multi-Access Edge Computing
Authors: Han Ying , Liang Junbin , Lin Yun
Published: June 2023

In multi-access edge computing (MEC) networks, parallelized service function chains (P-SFCs) can provide low-delay network services for mobile users by deploying virtualized network functions (VNFs) to process user requests in parallel. These VNFs are unreliable due to software faults and server failures. A practical way to address this is to deploy idle backup VNFs (BVNFs) near these active VNFs and activate them when active VNFs fail. However, deploying BVNFs preempts server resources and decreases the number of accepted user requests. Thus, this paper proposes a reliability enhancement approach that uses BVNFs satisfying the delay requirement as active VNFs to form P-SFCs, which contributes to the delay reduction and reliability enhancement. Since the resource capacities of edge servers can only deploy a certain number of P-SFCs and BVNFs, establishing how to deploy the minimum number of P-SFCs and BVNFs to satisfy the delay and reliability requirements of mobile users and maximize the number of accepted user requests is a challenging problem. In this paper, we first model the dynamics of delay and reliability caused by VNF parallelization and BVNFs deployment, then formulate the joint deployment problem of P-SFCs and BVNFs. Next, we design an approximation algorithm to deploy critical VNFs and BVNFs on a target edge server and schedule the data traffic of user requests processed by P-SFCs. Experimental results based on real-world datasets show that our proposed algorithm outperforms two benchmark algorithms in terms of throughput, delay, reliability, and resource utilization.
Study on NDVI Periodic Change Characteristics of Inner Mongolia Grassland Based on Variational Mode Decomposition Algorithm
Authors: Su Deguo , Zhang Anbing , Tian Zhixiu , Liu Xinxia , Hou Yikai
Published: June 2023

Based on the NDVI data of vegetation in Inner Mongolia from 1982 to 2015, the variational mode decomposition (VMD) method, which has been well applied in the field of signal decomposition, is introduced to study the periodicity of vegetation index in Inner Mongolia. The VMD method is used to extract the monthly and annual NDVI and the long time series cycle characteristics of temperature and precipitation in the same period from April 1982 to October 2015 in Inner Mongolia. The results show that temperature and precipitation are important factors affecting the growth of vegetation, and there are 6.99 and 3.49 months of the same oscillation cycle for monthly NDVI and temperature and precipitation time series; when the central frequency is the same, the amplitude of the monthly temperature and precipitation time series increases with the increase of the lag period. The annual scale NDVI has the same period of 16.95, 6.8a, and 4.85a with precipitation, and the same period of 6.8a and 4.85a with temperature. The Residue component shows that the overall NDVI and temperature in Inner Mongolia have shown a significant slow growth trend in the past 30 years. Although the precipitation has shown a significant slow decline trend in the same time period (p = 0.000), the grassland is still in the process of continuous improvement.
Pathophysiology of Work-Related Neuropathies
Authors: Malik Tariq , Malik Ahmed , Abd-Elsayed Alaa
Published: June 2023

Work-related injuries are common. The cost of these injuries is around USD 176 billion to USD 350 billion a year. A significant number of work-related injuries involve nerve damage or dysfunction. Injuries may heal with full recovery of function, but those involving nerve damage may result in significant loss of function or very prolonged recovery. While many factors can predispose a person to suffer nerve damage, in most cases, it is a multifactorial issue that involves both intrinsic and extrinsic factors. This makes preventing work-related injuries hard. To date, no evidence-based guidelines are available to clinicians to evaluate work-related nerve dysfunction. While the symptoms range from poor endurance to cramping to clear loss of motor and sensory functions, not all nerves are equally vulnerable. The common risk factors for nerve damage are a superficial location, a long course, an acute change in trajectory along the course, and coursing through tight spaces. The pathophysiology of acute nerve injury is well known, but that of chronic nerve injury is much less well understood. The two most common mechanisms of nerve injury are stretching and compression. Chronic mild to moderate compression is the most common mechanism of nerve injury and it elicits a characteristic response from Schwann cells, which is different from the one when nerve is acutely injured. It is important to gain a better understanding of work-related nerve dysfunction, both from health and from regulatory standpoints. Currently, management depends upon etiology of nerve damage, recovery is often poor if nerves are badly damaged or treatment is not instituted early. This article reviews the current pathophysiology of chronic nerve injury. Chronic nerve injury animal models have contributed a lot to our understanding but it is still not complete. Better understanding of chronic nerve injury pathology will result in identification of novel and more effective targets for pharmacological interventions.
Experimental Study on the Bonding Performance between Fiber-Belt-Bar and Concrete
Authors: Gu Wenhu , Chen Jiarui , Li Qirong , Ji Rundong , Ji Jianzhong
Published: June 2023

Fiber materials have advantages such as light weight and high strength, corrosion resistance, fatigue resistance, and easy processing and production, and they are widely applied in the repair and renovation of concrete structures. To promote the construction convenience of fiber materials, fiber raw yarn is continuously braided to form fiber-belt-bars. Based on the existing research, the performance of bonding between fiber-belt-bars and a concrete interface was investigated, and pull-out tests were performed to systematically investigate the effects of the fiber-belt-bar cross-sectional size, anchorage length, concrete strength, and fiber type on the bonding performance. The experimental results show that the bond strength reduces with an increase in the anchorage length, increase in cross-sectional size, and decrease in concrete strength, and the effect of fiber type on the bond strength is not obvious. On this basis, a formula for calculating the average bond strength of fiber-belt-bars is proposed. Experiments and calculations determined that the average bond strength between fiber-belt-bar and concrete with a cross-sectional size of 12 mm × 3 mm is 10–30% higher than that with a cross-sectional size of 20 mm × 3 mm for the same anchorage length. Finally, the minimum anchorage length of the fiber-belt-bar is proposed to provide a valuable reference for the use of fiber-belt-bar in concrete projects.
Research on Fatigue Performance of Shape-Memory Alloy Bars under Low Cyclic Loading
Authors: Li Lei , Zhao Xianxian , Cheng Junwei
Published: June 2023

In recent years, shape memory alloys (SMAs) have been applied in the vibration control of engineering structures due to their special properties such as super elasticity and high damping, and the study of the performance of SMA wires has been relatively comprehensive, while research on the fatigue performance of SMA bars via cyclic tensile tests has been pretty rare, and low-cycle fatigue test has not been reported. However, the damage to building structures caused by earthquakes is of high-strain, low-cycle fatigue; therefore, in order for SMA bars to be used in seismic design, low-cycle fatigue tests were conducted on SMA bars with a diameter of 14 mm in this paper. Firstly, specimens were heat treated at a constant temperature of 350 °C for 30 min; other specimens were heat treated at a constant temperature of 400 °C for 15 min, while the rests were heat treated under a constant temperature of 400 °C for 30 min. Secondly, the energy dissipation capacity and residual strain of the SMA bar specimens were determined using the low-cycle fatigue test, in which the strain amplitudes were 2.5%, 3.5% and 3.75%. Additionally, the stress–strain relationship for SMA bars under cyclic loading was given. Finally, low-cycle fatigue properties of SMA bars were numerically simulated in the comparison analysis with the experimental results to verify their feasibility. Thus, it is proved that SMA bars can be recommend for seismic design building structures.
Autologous Transplantation May Still Effectively Treat Relapsed Diffuse Large B-Cell Lymphoma in Selected Patients
Authors: Bicsko Reka Rahel , Antal Lili , Magyari Ferenc , Szász Róbert , Udvardy Miklós , Illes Arpad , Gergely Lajos
Published: June 2023

Treating relapsed and refractory diffuse large B-cell lymphoma is still challenging for clinicians, but the available CAR-T and bispecific antibodies have revolutionized therapy. Autologous stem cell transplantation was the most effective treatment modality previously. The authors reported data from a single center over ten years. The retrospective study included 116 patients, with 53 relapsed cases, 39 primary refractory cases, 19 who had CNS involvement, and 5 who had received primary consolidation transplants. The median duration of follow-up was 46 months. The median event-free survival was 75 months, and the median overall survival was 105 months for all cases. Five-year overall survival was 59%, and event-free survival was 54%. Pretreatment prognostic factors at diagnosis had no effect on the outcome of transplantation. The authors found no difference between survival in relapsed or refractory cases, and the number of salvage lines or the germinal center/activated B-cell type also did not influence the results. Complete metabolic response before transplantation confirmed by 18FDG PET/CT strongly affected survival. The pre-transplant creatinine and CRP levels significantly influenced the long-term outcome. The number of stem cells infused did not affect survival, but engraftment within nine days did result in a longer survival. These data support the finding that the response to salvage therapy did facilitate the identification of a better prognostic group who may still benefit from autologous transplantation.
The Safe Use of 125I-Seeds as a Localization Technique in Breast Cancer during Pregnancy
Authors: Heeling Eva , van de Kamer Jeroen B. , Methorst Michelle , Bruining Annemarie , van de Meent Mette , Vrancken Peeters Marie-Jeanne T. F. D. , Lok Christianne A. R. , van der Ploeg Iris M. C.
Published: June 2023

Introduction: Some aspects of the treatment protocol for breast cancer during pregnancy (PrBC) have not been thoroughly studied. This study provides clarity regarding the safety of the use of 125I-seeds as a localization technique for breast-conserving surgery in patients with PrBC. Methods: To calculate the exposure to the fetus of one 125I-seed implanted in a breast tumor, we developed a model accounting for the decaying 125I-source, time to surgery, and the declining distance between the 125I-seed and the fetus. The primary outcome was the maximum cumulative fetal dose of radiation at consecutive gestational ages (GA). Results: The cumulative fetal dose remains below 1 mSv if a single 125I-seed is implanted at a GA of 26 weeks. After a GA of 26 weeks, the fetal dose can be at a maximum of 11.6 mSv. If surgery takes place within two weeks of implantation from a GA of 26 weeks, and one week above a GA of 32 weeks, the dose remains below 1 mSv. Conclusion: The use of 125I-seeds is safe in PrBC. The maximum fetal exposure remains well below the threshold of 100 mSv, and therefore, does not lead to an increased risk of fetal tissue damage. Still, we propose keeping the fetal dose as low as possible, preferably below 1 mSv.
Metabolomics-Guided Identification of a Distinctive Hepatocellular Carcinoma Signature
Authors: Tambay Vincent , Raymond Valérie-Ann , Goossens Corentine , Rousseau Louise , Turcotte Simon , Bilodeau Marc
Published: June 2023

Background: Hepatocellular carcinoma (HCC) is a major contributor to cancer-related morbidity and mortality burdens globally. Given the fundamental metabolic activity of hepatocytes within the liver, hepatocarcinogenesis is bound to be characterized by alterations in metabolite profiles as a manifestation of metabolic reprogramming. Methods: HCC and adjacent non-tumoral liver specimens were obtained from patients after HCC resection. Global patterns in tissue metabolites were identified using non-targeted 1H Nuclear Magnetic Resonance (1H-NMR) spectroscopy whereas specific metabolites were quantified using targeted liquid chromatography–mass spectrometry (LC/MS). Results: Principal component analysis (PCA) within our 1H-NMR dataset identified a principal component (PC) one of 53.3%, along which the two sample groups were distinctively clustered. Univariate analysis of tissue specimens identified more than 150 metabolites significantly altered in HCC compared to non-tumoral liver. For LC/MS, PCA identified a PC1 of 45.2%, along which samples from HCC tissues and non-tumoral tissues were clearly separated. Supervised analysis (PLS–DA) identified decreases in tissue glutathione, succinate, glycerol-3-phosphate, alanine, malate, and AMP as the most important contributors to the metabolomic signature of HCC by LC/MS. Conclusions: Together, 1H-NMR and LC/MS metabolomics have the capacity to distinguish HCC from non-tumoral liver. The characterization of such distinct profiles of metabolite abundances underscores the major metabolic alterations that result from hepatocarcinogenesis.
Dose Optimization in Oncology Drug Development: The Emerging Role of Pharmacogenomics, Pharmacokinetics, and Pharmacodynamics
Authors: Papachristos Apostolos , Patel Jai , Vasileiou Maria , Patrinos George P.
Published: June 2023

Drugs’ safety and effectiveness are evaluated in randomized, dose-ranging trials in most therapeutic areas. However, this is only sometimes feasible in oncology, and dose-ranging studies are mainly limited to Phase 1 clinical trials. Moreover, although new treatment modalities (e.g., small molecule targeted therapies, biologics, and antibody-drug conjugates) present different characteristics compared to cytotoxic agents (e.g., target saturation limits, wider therapeutic index, fewer off-target side effects), in most cases, the design of Phase 1 studies and the dose selection is still based on the Maximum Tolerated Dose (MTD) approach used for the development of cytotoxic agents. Therefore, the dose was not optimized in some cases and was modified post-marketing (e.g., ceritinib, dasatinib, niraparib, ponatinib, cabazitaxel, and gemtuzumab-ozogamicin). The FDA recognized the drawbacks of this approach and, in 2021, launched Project Optimus, which provides the framework and guidance for dose optimization during the clinical development stages of anticancer agents. Since dose optimization is crucial in clinical development, especially of targeted therapies, it is necessary to identify the role of pharmacological tools such as pharmacogenomics, therapeutic drug monitoring, and pharmacodynamics, which could be integrated into all phases of drug development and support dose optimization, as well as the chances of positive clinical outcomes.
Role of Therapeutic Endoscopic Ultrasound in Management of Pancreatic Cancer: An Endoscopic Oncologist Perspective
Authors: Dahiya Dushyant Singh , Chandan Saurabh , Ali Hassam , Pinnam Bhanu Siva Mohan , Gangwani Manesh Kumar , Al Bunni Hashem Al , Canakis Andrew , Gopakumar Harishankar , Vohra Ishaan , Bapaye Jay , Al-Haddad Mohammad , Sharma Neil R.
Published: June 2023

Pancreatic cancer is a highly lethal disease with an aggressive clinical course. Patients with pancreatic cancer are usually asymptomatic until significant progression of their disease. Additionally, there are no effective screening guidelines for pancreatic cancer in the general population. This leads to a delay in diagnosis and treatment, resulting in poor clinical outcomes and low survival rates. Endoscopic Ultrasound (EUS) is an indispensable tool for the diagnosis and staging of pancreatic cancer. In the modern era, with exponential advancements in technology and device innovation, EUS is also being increasingly used in a variety of therapeutic interventions. In the context of pancreatic cancer where therapies are limited due to the advanced stage of the disease at diagnosis, EUS-guided interventions offer new and innovative options. Moreover, due to their minimally invasive nature and ability to provide real-time images for tumor localization and therapy, they are associated with fewer complication rates compared to conventional open and laparoscopic approaches. In this article, we detail the most current and important therapeutic applications of EUS for pancreatic cancer, namely EUS-guided Fine Needle Injections, EUS-guided Radiotherapy, and EUS-guided Ablations. Furthermore, we also discuss the feasibility and safety profile of each intervention in patients with pancreatic cancer to provide gastrointestinal medical oncologists, radiation and surgical oncologists, and therapeutic endoscopists with valuable information to facilitate patient discussions and aid in the complex decision-making process.