bluuebunny/crossref_metadata_2025 huggingface dataset:
Parents’ rearing styles and adolescents’ math achievement: the multiple mediating effect of self-control and math anxiety
Authors: Wang Yanjiao , Han Lei , Tao Yang , Ma Yanyan
Published: October 2024

Introduction

This cross-sectional study examined the mechanisms underlying adolescent math achievement by investigating the relationship between parents’ rearing styles (including different dimensions of rearing style) and adolescent self-control, math anxiety, and math achievement based on the ecological systems theory.

Method

A total of 584 junior high school students (M age = 12.52) completed the Parenting Style Questionnaire, Self-control Scale, and Math Anxiety Rating Scale and provided their math test scores.

Results

The rearing styles of both fathers and mothers directly predicted adolescents’ math achievement. Maternal rearing style indirectly predicted adolescents’ math achievement through their self-control and math anxiety; however, the indirect effect of paternal rearing style on adolescents’ math achievement was not significant. After distinguishing the three dimensions of rearing styles, we found that paternal emotional warmth can increase adolescents’ self-control, while maternal emotional warmth can reduce adolescents’ self-control. Further, paternal overprotectiveness can directly and positively predict adolescents’ math achievement, while maternal rejection and overprotectiveness can positively predict adolescents’ math achievement. None of the three dimensions of rearing styles can predict math achievement through adolescents’ self-control; however, they can predict math achievement indirectly through adolescents’ math anxiety and the chain-mediation of adolescents’ self-control and math anxiety.

Discussion

Our results suggest both commonalities and differences in how paternal and maternal rearing styles, along with their three dimensions (emotional warmth, rejection, overprotection), predict adolescent math achievement. These findings highlight the importance of paternal and maternal rearing styles on adolescents’ math achievement and underscore the need to examine them separately to better understand their impact.
A review on the efficacy of artificial intelligence for managing anxiety disorders
Authors: Das K. P. , Gavade P.
Published: October 2024

Anxiety disorders are psychiatric conditions characterized by prolonged and generalized anxiety experienced by individuals in response to various events or situations. At present, anxiety disorders are regarded as the most widespread psychiatric disorders globally. Medication and different types of psychotherapies are employed as the primary therapeutic modalities in clinical practice for the treatment of anxiety disorders. However, combining these two approaches is known to yield more significant benefits than medication alone. Nevertheless, there is a lack of resources and a limited availability of psychotherapy options in underdeveloped areas. Psychotherapy methods encompass relaxation techniques, controlled breathing exercises, visualization exercises, controlled exposure exercises, and cognitive interventions such as challenging negative thoughts. These methods are vital in the treatment of anxiety disorders, but executing them proficiently can be demanding. Moreover, individuals with distinct anxiety disorders are prescribed medications that may cause withdrawal symptoms in some instances. Additionally, there is inadequate availability of face-to-face psychotherapy and a restricted capacity to predict and monitor the health, behavioral, and environmental aspects of individuals with anxiety disorders during the initial phases. In recent years, there has been notable progress in developing and utilizing artificial intelligence (AI) based applications and environments to improve the precision and sensitivity of diagnosing and treating various categories of anxiety disorders. As a result, this study aims to establish the efficacy of AI-enabled environments in addressing the existing challenges in managing anxiety disorders, reducing reliance on medication, and investigating the potential advantages, issues, and opportunities of integrating AI-assisted healthcare for anxiety disorders and enabling personalized therapy.
Optimising availability and geographical accessibility to emergency obstetric care within a sub-national social health insurance scheme in Nigeria
Authors: Banke-Thomas Aduragbemi , Olubodun Tope , Olaniran Abimbola A. , Wong Kerry L. M. , Shah Yash , Achugo Daniel C. , Ogunyemi Olakunmi
Published: October 2024

Introduction

Health insurance is a key instrument for a health system on its path to achieving universal health coverage (UHC) and protects individuals from catastrophic health expenditures, especially in health emergencies. However, there are other dimensions to care access beyond financial accessibility. In this study, we assess the geographical accessibility of comprehensive emergency obstetric care (CEmOC) within the Lagos State Health Insurance Scheme.

Methods

We geocoded functional public and private CEmOC facilities, established facilities registered on the insurance panel as of December 2022, and assembled population distribution for women of childbearing age. We used Google Maps Platform's internal directions application programming interface to obtain driving times to facilities. State- and local government area (LGA)-level median travel time (MTT) and a number of CEmOC facilities reachable within 30 min were obtained for peak travel hours.

Results

Across Lagos State, MTT to the nearest public CEmOC was 25 min, reduced to 17 min with private facilities added to the insurance panel. MTT to the nearest public facility in LGAs ranged from 9 min (Lagos Island) to 51 min (Ojo) (median = 25 min). With private facilities added, MTT ranged from 5 min (Agege and Ajeromi-Ifelodun) to 36 min (Ibeju-Lekki) (median = 13 min). On average, no public CEmOC facility was reachable within 30 min of driving for women living in 6 of 20 LGAs. With private facilities included in the scheme, reachable facilities within 30 min remained zero in one LGA (Ibeju-Lekki).

Conclusions

Our innovative approach offers policy-relevant evidence to optimise insurance coverage, support efforts in advancing UHC, ensure coverage for CEmOC, and improve health system performance.
From Text to Safety: A Novel Framework for Mining Unsafe Aviation Events Using Advanced Neural Network and Feature Network
Authors: Wang Qiang , Xia Ruicong , Yu Jiayang , Liu Qiuhan , Tong Sirong , Xu Ziling
Published: October 2024

The rapid growth of the aviation industry highlights the need for strong safety management. Analyzing data on unsafe aviation events is crucial for preventing risks. This paper presents a new method that integrates the Transformer network model, clustering analysis, and feature network modeling to analyze Chinese text data on unsafe aviation events. Initially, the Transformer model is used to generate summaries of event texts, and the performance of three pre-trained Chinese models is evaluated and compared. Next, the Jieba tool is applied to segment both summarized and original texts to extract key features of unsafe events and prove the effectiveness of the pre-trained Transformer model in simplifying lengthy and redundant original texts. Then, cluster analysis based on text similarity categorizes the extracted features. By solving the correlation matrix of these features, this paper constructs a feature network for unsafe aviation events. The network’s global and individual metrics are calculated and then used to identify key feature nodes, which alert aviation professionals to focus more on the decision-making process for safety management. Based on the established network and these metrics, a data-driven hidden danger warning strategy is proposed and illustrated. Overall, the proposed method can effectively analyze Chinese texts of unsafe aviation events and provide a basis for improving aviation safety management.
Research on the Structural Design of a Pressurized Cabin for Civil High-Speed Rotorcraft and the Multi-Dimensional Comprehensive Evaluation Method
Authors: Zhang Yongjie , Zhang Tongxin , Zhou Jingpiao , Cui Bo , Chen Fangyu
Published: October 2024

For civil high-speed rotorcraft designed to operate at specific cruising altitudes, this study proposes nine structural design schemes for pressurized cabins. These schemes integrate commonly used materials and processing technologies in the aviation industry with advanced PRSEUS (Pultruded Rod Stitched Efficient Unitized Structure) technology. An analysis of the structural composition reveals that frames constitute 8–19% of the total structural weight, while stringers and beams make up 15–50%, and skins account for 11–25%, with thicknesses ranging from 1.0 mm to 2.0 mm. The separating interface of the pressurized cabin contributes 4–29% of the total structural weight. The weight distribution of each component in the pressurized cabin structure varies significantly depending on the chosen materials and processing technologies. Utilizing the Analytic Hierarchy Process (AHP), along with Gray Relational Analysis (GRA) and Dempster–Shafer (D-S) evidence theory, this study compares the simulation results of the nine schemes across multiple dimensions. The findings indicate that the configuration combining 7075 aluminum alloy and T300 composite material has the greatest advantages in terms of the high structural reliability of the configuration, light weight, mature processing technology, and low production cost. This comprehensive evaluation method quantitatively analyzes the factors influencing the structural configuration design of the pressurized cabin for civil high-speed rotorcraft, offering a valuable reference for the design of similar structures in related fields.
Research on the Design and Bidirectional Work Process of Metal Diaphragms in Small Double-Pulse Solid Rocket Motors
Authors: Du Xueqin , Hui Weihua , Tan Youwen , Feng Wen , Liu Yang
Published: October 2024

According to the requirements of the small double-pulse solid rocket motor, a compartmentalized isolation device has been designed. This device consists of a metal diaphragm and a support frame. An experimental study and numerical simulation were used to verify the bidirectional working process of the metal diaphragm during operation of the double-pulse motor. The results show that the pressure-bearing capacity of the metal diaphragm meets the requirements under the working conditions of pulse I without affecting pulse II, because the metal diaphragm can provide insulation and flame retardancy. The metal diaphragm can be cracked in the direction of the preset V-groove in a relatively short time under the working conditions of pulse II, which allows the gas to flow to the first pulse combustion chamber normally. This indicates that the metal diaphragm can meet the requirements of bidirectional working process in dual-pulse motors.
The Influence of Bleed Position on the Stability Expansion Effect of Self-Circulating Casing Treatment
Authors: Zhang Haoguang , Xiao Jinhang , Zhong Xinyi , Feng Yiming , Chu Wuli
Published: October 2024

The self-circulating casing treatment can effectively expand the stable working range of the compressor, with little impact on its efficiency. With a single-stage transonic axial flow compressor NASA (National Aeronautics and Space Administration) Stage 35 as the research object, a multi-channel unsteady numerical calculation method was used here to design three types of self-circulating casing treatment structures: 20% Ca (axial chord length of the rotor blade tip), 60% Ca, and 178% Ca (at this time, the bleed position is at the stator channel casing) from the leading edge of the blade tip. The effects of these three bleed positions on the self-circulating stability expansion effect and compressor performance were studied separately. The calculation results indicate that the further the bleed position is from the leading edge of the blade tip, the weaker the expansion ability of the self-circulating casing treatment, and the greater the negative impact on the peak efficiency and design point efficiency of the compressor. This is because the air inlet of the self-circulating casing with an air intake position of 20% Ca is located directly above the core area of the rotor blade top blockage, which can more effectively extract low-energy fluid from the blockage area. Compared to the other two bleed positions, it has the greatest inhibitory effect on the leakage vortex in the rotor blade tip gap and has the strongest ability to improve the blockage at the rotor blade tip. Therefore, 20% Ca from the leading edge of the blade tip has the strongest stability expansion ability, achieving a stall margin improvement of 11.28%.
Combining Physiology and Transcriptome Data Screening for Key Genes in Actinidia arguta Response to Waterlogging Stress
Authors: Geng Jiaqi , Shi Guangli , Li Xiang , Liu Yumeng , An Wenqi , Sun Dan , Wang Zhenxing , Ai Jun
Published: October 2024

Actinidia arguta is a cold-resistant fruit tree but intolerant to waterlogging. Waterlogging stress is the major abiotic stress in A. arguta growth, and several pathways are involved in the response mechanisms. Fifteen physiological indices and transcriptome data of two A. arguta cultivars, which showed two forms under waterlogging, were used to identify the major factor following the leaf senescence in waterlogging. Through principal component analysis (PCA) of 15 physiological indices in ‘Kuilv’ and ‘Lvwang’, the hormone contents were selected as the most important principal component (PCA 2) out of four components in response to waterlogging stress. According to the analysis of transcriptome data, 21,750 differentially expressed genes were identified and 10 genes through WGCNA, including hormone metabolism and sucrose metabolism, were screened out on the 6th day of waterlogging. In particular, the ABA signal transduction pathway was found to be closely related to the response to waterlogging based on the correlation analysis between gene expression level and plant hormone content, which may have regulated physiological indicators and morphological changes together with other hormones. Overall, the phenomenon of leaves falling induced by ABA might be a protective mechanism. The results provided more insights into the response mechanism of coping with waterlogging stress in A. arguta.
Feasibility of Nondestructive Soluble Sugar Monitoring in Tomato: Quantified and Sorted through ATR-FTIR Coupled with Chemometrics
Authors: Lv Gaoqiang , Zhang Wenya , Liu Xiaoyue , Zhang Ji , Liu Fei , Mao Hanping , Sun Weihong , Han Qingyan , Song Jinxiu
Published: October 2024

As a fast detection method, Fourier transform infrared attenuated total reflection (ATR-FTIR) spectroscopy is seldom used for monitoring soluble sugars in crops. This study aimed to demonstrate the feasibility of leveraging ATR-FTIR coupled with chemometrics to quantify and sort the contents of soluble sugar in tomatoes. Firstly, 192 tomato samples were scanned using ATR-FTIR; subsequently, a quantitative model was developed using PLSR with selected wavelength variables as inputs. Finally, a classification model was estimated through probabilistic neural network (PNN) to determine the samples. The results indicated that ATR-FTIR had successfully captured the spectra from the cellular layers of tomatoes, resulting in a robust PLSR model created by 468 selected variables with a R² value of 0.86, a RMSEP of 0.71%, a ratio of performance to relative percent deviation (RPD) of 1.87, and a ratio of prediction to interquartile range (RPIQ) of 2.1. Meanwhile, the PNN model demonstrated a high rate correct (RC) of 92.17% in identifying whether the samples with a higher soluble sugar content than the limit of detection (LOD at 2.1%). Overall, ATR-FTIR coupled with chemometrics has proven effective for non-destructive determination of soluble sugars in tomatoes, offering new insights into internal monitoring techniques for crop quality assurance.
Crucial Factors Influencing the Efficiency of Androgenesis in Oat (Avena sativa L.) Through Anther and Microspore Cultures
Authors: Grela Magdalena , Czyczyło-Mysza Ilona , Skrzypek Edyta
Published: October 2024

Historically, traditional crossbreeding schemes have predominated in oat breeding. In vitro culture techniques seek to expedite the breeding process and enhance selection efficiency. Maximum yields are achieved from hybrid plants produced by crossing pure (homozygous) lines with the desired traits. Homozygous lines can be produced through conventional breeding methods, which are time-consuming and costly. Alternatively, the production of homozygous lines can be accelerated by producing doubled haploid (DH) plants derived from (haploid) male gametophytes or their microspores (androgenesis). This method condenses the various stages required for producing homozygous lines in a single generation, resulting in significant time and cost savings. These and other advantages render androgenic DHs the preferred choice in numerous important crops where any of the various in vitro experimental techniques (anthers culture or isolated microspores culture) are well-established. However, in the case of oat (Avena sativa L.), an efficient plant regeneration method remains not very effective compared to the most common cereals, possibly due to the known recalcitrance of this cereal to in vitro culture. This review presents the methods through anther and microspore cultures utilized in the production of oat DHs revealing the crucial factors influencing the efficiency of this method in oat (Avena sativa L.).
Ruminal Crude Protein Degradation Determined in Sacco and by Co-Incubation of Streptomyces griseus Protease and Carbohydrases
Authors: Okon Paul , Wensch-Dorendorf Monika , Bachmann Martin , von Soosten Dirk , Meyer Ulrich , Greef Jörg-Michael , Dänicke Sven , Zeyner Annette
Published: October 2024

The objectives of the study were to examine the effect of an antibiotic solution applied in the Streptomyces griseus protease method (SGPM) and the effect of carbohydrases in SGPM on the effective crude protein (CP) degradation (ED) with reference to in sacco ED. For this purpose, the ruminal CP degradation of rapeseed meal, dried distillers’ grains with solubles, wheat grain, corn grain, corn silage, grass silage and partial crop field pea silage was determined in sacco using three rumen-fistulated dairy cows and in vitro using SGPM. The impact of the antibiotic solution on CP degradation by S. griseus protease was investigated by supplementing SGPM with Penicillin–Streptomycin solution to reduce microbial mass proliferation during incubation. The carbohydrase α-amylase or Viscozym® L (cell wall-degrading enzyme mixture) was added to the SGPM at four different doses simultaneously as a co-incubation to improve feed protein accessibility. For most feedstuffs, ED was lower when the antibiotic solution was used in SGPM (p < 0.05). The use of an antibiotic solution in the SGPM is recommended to standardize the SGPM. The in sacco ED values were significantly underestimated by the SGPM and by the SGPM with co-incubated carbohydrase (p < 0.05). Co-incubation of S. griseus protease and carbohydrase was not successful in reducing the differences to the in sacco CP degradation.
Comparative Effects of Crude Extracts and Bioactive Compounds from Bidens pilosa and Bidens alba on Nonspecific Immune Responses and Antibacterial Activity Against Vibrio sp. in Coculture with Lactic Acid Bacteria in Hybrid Grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂)
Authors: Widodo Ari , Huang Huai-Ting , Dewi Novi Rosmala , Chen Bo-Ying , Wu Yu-Sheng , Hu Yeh-Fang , Nan Fan-Hua
Published: October 2024

This study investigated the effect of substances on nonspecific immune responses of head kidney leukocytes, the antimicrobial activity against Vibrio sp., as well as the time-kill of Vibrio sp. by combining the substances with lactic acid bacteria (LAB) and Pediococcus sp. The substances are B. pilosa hot water extract, B. pilosa powder extract, B. pilosa methanol extract, B. pilosa ethanol extract, B. alba hot water extract, B. alba powder extract, B. alba methanol extract, B. alba ethanol extract, and bioactive compounds, namely cytopiloyne, flavonoid, phenol, ethyl caffeate, luteolin, chlorogenic acid, butein, and linoleic acid. The results showed that some of them were nontoxic to the head kidney leukocytes, which can increase the phagocytic rate, phagocytic index, and respiratory burst. These substances were able to inhibit the growth of Vibrio sp.; they can even completely kill the pathogenic bacteria. The largest of the inhibition zone formed from the EC group at a concentration range of 5–50 µg/mL against V. parahaemolyticus, V. alginolyticus, and V. harveyi with a value of 19.7 ± 0.56, 19.3 ± 1.53, and 20.6 ± 1.53 mm. Furthermore, the time-kill studies showed that the LAB and P. acidilactici can completely kill the Vibrio sp. at 6 h incubation time, mainly in the group of combination with EC.
Oxidative Stress in Cataract Formation: Is There a Treatment Approach on the Horizon?
Authors: Li Jingyan , Buonfiglio Francesco , Zeng Ying , Pfeiffer Norbert , Gericke Adrian
Published: October 2024

Cataracts, a leading cause of blindness worldwide, are closely linked to oxidative stress-induced damage to lens epithelial cells (LECs). Key factors contributing to cataract formation include aging, arterial hypertension, and diabetes mellitus. Given the high global prevalence of cataracts, the burden of cataract-related visual impairment is substantial, highlighting the need for pharmacological strategies to supplement surgical interventions. Understanding the molecular pathways involved in oxidative stress during cataract development may offer valuable insights for designing novel therapeutic approaches. This review explores the role of oxidative stress in cataract formation, focusing on critical mechanisms, such as mitochondrial dysfunction, endoplasmic reticulum stress, loss of gap junctions, and various cell death pathways in LECs. Additionally, we discuss emerging therapeutic strategies and potential targeting options, including antioxidant-based treatments.
Analytical Hierarchy Process for Construction Safety Management and Resource Allocation
Authors: Zeibak-Shini Reem , Malka Hofit , Kima Ovad , Shohet Igal M.
Published: October 2024

The construction industry plays a crucial role in contributing to the economy and developing sustainable infrastructures. However, it is known as one of the most dangerous industrial domains. Over the years, special attention has been paid to developing models for managing and planning construction safety. Many research studies have been carried out to analyze the root causes of fatal accidents in construction sites to develop models for preventing them and mitigating their consequences. Root cause identification and analysis are essential for effective risk mitigation. However, implementing mitigation activities is usually limited to the project’s safety budget. The construction sector suffers from a lack of allocation of appropriate safety resources triggered by a dynamic and complex project environment. This study aims to address the gap in safety resource allocation through a comprehensive root cause analysis of construction work accidents. In this paper, we present a comprehensive review of work accident-related research, categorized according to the 5M model into five root factors: medium, mission, man, management, and machinery. A novel methodology for construction safety resource allocation is proposed to mitigate risks analyzed by the 5M model with the aid of advanced technological solutions. Safety resource allocation alternatives are formulated, and their priorities are established based on an analysis of structured criteria that integrate both risk and cost considerations. The Analytical Hierarchy Process (AHP) is employed to select the optimal alternative for safety resource allocation, with the objective of effective risk mitigation. The proposed model underwent validation through two different case studies. The findings indicate that risk aversion is a critical factor in the optimal allocation of safety resources. Furthermore, the results suggest that regulatory measures should prioritize the stimulation of risk motivation in the safety decision-making processes of construction firms.
Dynamic Sliding Mode Control of Spherical Bubble for Cavitation Suppression
Authors: Karami-Mollaee Ali , Barambones Oscar
Published: October 2024

Cavitation is a disadvantageous phenomenon that occurs when fluid pressure drops below its vapor pressure. Under these conditions, bubbles form in the fluid. When these bubbles flow into a high-pressure area or tube, they erupt, causing harm to mechanical parts such as centrifugal pumps. The difference in pressure in a fluid is the result of varying temperatures. One way to eliminate cavitation is to reduce the radius of the bubbles to zero before they reach high-pressure areas, using a robust approach. In this paper, sliding mode control is used for this purpose due to its invariance property. To force the radius of the bubbles toward zero and prevent chattering, a new dynamic sliding mode control approach is used. In dynamic sliding mode control, chattering is removed by passing the input control through a low-pass filter, such as an integrator. A general model of the spherical bubble is used, transferred to the state space, and then a state proportional-integral feedback is applied to obtain a linear system with a new input control signal. A comparison is also made with traditional sliding mode control using state feedback, providing a trusted comparison.
One Hundred Years of Progress and Pitfalls: Maximising Heterosis through Increasing Multi-Locus Nuclear Heterozygosity
Authors: Hallahan Brendan F.
Published: October 2024

The improvement in quantitative traits (e.g., yield, size) in F1 offspring over parent lines is described as hybrid vigour, or heterosis. There exists a fascinating relationship between parental genetic distance and genome dosage (polyploidy), and heterosis effects. The contribution of nuclear heterozygosity to heterosis is not uniform across diploid and polyploid crops, even within same species, thus demonstrating that polyploid crops should be part of any discussion on the mechanisms of heterosis. This review examines the records of correlating heterosis with parental genetic distance and the influence of adding supplementary genomes in wide crosses. Increasing nuclear heterozygosity through parental genetic distance has been shown to be an imperfect predictor for heterosis in a variety of commercial crops such as maize, rice, and pepper. However, increasing the ploidy level raises the maximum number of alleles that can be harboured at any one locus, and studies on crops such as oilseed rape, potato, alfalfa, maize, and rice have demonstrated that heterosis may be maximised upon increasing multi-locus nuclear heterozygosity. The novel heterotic phenotypes observed above the diploid level will contribute to our understanding on the mechanisms of heterosis and aid plant breeders in achieving the righteous goal of producing more food with fewer inputs.
Vegetation Succession for 12 Years in a Pond Created Restoratively
Authors: Lee Chang-Seok , Kim Dong-Uk , Lim Bong-Soon , Seok Ji-Eun , Kim Gyung-Soon
Published: October 2024

The Najeoer Pond was created in a rice paddy as a part of a plan to build the National Institute of Ecology. To induce the establishment of various plants, the maximum depth of the pond was 2.0 m, and diverse depths were created with a gentle slope on the pond bed. When introducing vegetation, littoral and emergent vegetation were first introduced to stabilize the space secured for the creation of the pond, whereas the introduction of other vegetation was allowed to develop naturally. In this pond, floating, emergent, wetland, and littoral plants have been established to various degrees, reflecting the water depth and water table. As a result of stand ordination, based on vegetation data obtained from the created Najeoer Pond and a natural lagoon selected as the reference site, the species’ composition resembled that of the reference site. Diversity, based on vegetation type, community, and species, tended to be higher than that of the reference site. The proportion of exotic species increased due to the disturbance that occurred during the pond creation process but continued to decrease as the vegetation introduced during the creation of the pond became established. Considering these results comprehensively, the restorative treatment served to increase both the biological integrity and ecological stability of the pond and, thus, achieved the creation goal from the viewpoint of the pond structure.
Effects of Pirimiphos-Methyl on Non-Target Invertebrates
Authors: Faly Liudmyla , Brygadyrenko Viktor
Published: October 2024

The effects of pirimiphos-methyl have previously been assessed on blood-sucking insect species, pollinating insects, and target crop pest species. The sensitivity of non-target zoophagous and saprophage species to this insecticide remains largely unstudied. In laboratory conditions, we assessed the susceptibility of 43 species of invertebrates to pirimiphos-methyl. The most tolerant species to this insecticide were Pyrrhocoris apterus (LC50 measured over 60 mg/m2), Cylindroiulus truncorum, Pterostichus niger, Harpalus rufipes, Lithobius forficatus, and Carabus hortensis (LC50 ranged from 25 to 50 mg/m2). Average tolerance to pirimiphos-methyl was displayed by Ophonus rufibarbis, Teuchestes fossor, Silpha carinata, Badister sodalis, Rugilus rufipes, Phosphuga atrata, Porcellio laevis, Pterostichus oblongopunctatus, Aphodius foetens, Lasius fuliginosus, Oxypselaphus obscurus, Platydracus fulvipes, Myrmica ruginodis, Xantholinus tricolor, and Megaphyllum sp. (LC50 for those species ranged from 12 to 24 mg/m2). Higher sensitivity to this insecticide was seen for Amara nitida, Leistus ferrugineus, Harpalus xanthopus winkleri, Philonthus nitidus, Pterostichus melanarius, Harpalus latus, Limodromus assimilis, Philonthus decorus, Tachinus signatus, Ponera coarctata, Carabus convexus, Philonthus coprophilus, Philonthus laevicollis, Platydracus latebricola, Labia minor, and Carabus granulatus (LC50 for those species ranged from 6 to 12 mg/m2). The greatest sensitivity to pirimiphos-methyl was observed in Hister fenestus, Drusilla canaliculata, Bisnius fimetarius, Oxytelus sculptus, Lasius niger, and Lasius flavus (LC50 ranged from 0.4 to 6 mg/m2). We found a relationship between the parameters of bodies of invertebrates (the average body length and dry body mass) and sensitivity to pirimiphos-methyl. With an increase in body sizes of invertebrates, the tolerance to the insecticide increased (per each mm of body length, LC50 increased by 0.82 mg/m2 on average). We identified no relationship between the trophic specialization and sensitivity to the insecticide.
Extracellular Vesicles Contribute to Oxidized LDL-Induced Stromal Cell Proliferation in Benign Prostatic Hyperplasia
Authors: Roldán Gallardo Franco F. , Martínez Piñerez Daniel E. , Reinarz Torrado Kevin F. , Berg Gabriela A. , Herzfeld Jael D. , Da Ros Vanina G. , López Seoane Manuel , Maldonado Cristina A. , Quintar Amado A.
Published: October 2024

Background: Clinical and experimental evidence has linked Benign Prostatic Hyperplasia (BPH) with dyslipidemic and hypercholesterolemic conditions, though the underlying cellular mechanisms remain unclear. This study investigates the impact of dyslipidemia, specifically oxidized LDL (OxLDL), on prostatic stromal cell proliferation and the release of extracellular vesicles (EVs). Methods: Mice were fed a high-fat diet, and human prostatic stromal cells (HPSCs) were treated with OxLDL. Proliferation assays and EV characterization were performed to assess the role of EVs in BPH progression. Results: Pro-atherogenic conditions significantly increased cell proliferation in both murine prostatic cells and HPSCs. Treatment with metformin effectively inhibited OxLDL-induced proliferation. Additionally, OxLDL stimulated the production and release of pro-proliferative EVs by HPSCs, which further promoted cellular proliferation. Conclusions: The findings suggest that dyslipidemia drives prostatic stromal cell proliferation and EV secretion, contributing to BPH progression. Metformin demonstrates potential as a therapeutic agent to mitigate these effects, offering insight into novel strategies for BPH management. This study highlights the complex interaction between dyslipidemia, cell proliferation, and extracellular communication in the context of BPH pathogenesis.
Peptide-Based Inhibitors of Protein–Protein Interactions (PPIs): A Case Study on the Interaction Between SARS-CoV-2 Spike Protein and Human Angiotensin-Converting Enzyme 2 (hACE2)
Authors: Rakhmetullina Aizhan , Zielenkiewicz Piotr , Odolczyk Norbert
Published: October 2024

Protein–protein interactions (PPIs) are fundamental to many critical biological processes and are crucial in mediating essential cellular functions across diverse organisms, including bacteria, parasites, and viruses. A notable example is the interaction between the SARS-CoV-2 spike (S) protein and the human angiotensin-converting enzyme 2 (hACE2), which initiates a series of events leading to viral replication. Interrupting this interaction offers a promising strategy for blocking or significantly reducing infection, highlighting its potential as a target for anti-SARS-CoV-2 therapies. This review focuses on the hACE2 and SARS-CoV-2 spike protein interaction, exemplifying the latest advancements in peptide-based strategies for developing PPI inhibitors. We discuss various approaches for creating peptide-based inhibitors that target this critical interaction, aiming to provide potential treatments for COVID-19.
Assessing the Cost-Effectiveness of Photobiomodulation for Oral Mucositis Prevention and Treatment: A Systematic Review
Authors: Parra-Rojas Susell , Cassol Spanemberg Juliana , del Mar Díaz-Robayna Nerea , Peralta-Mamani Mariela , Velázquez Cayón Rocío Trinidad
Published: October 2024

Background: We report on the cost-effectiveness of photobiomodulation (PBM) for the prevention and treatment of oral mucositis (OM) derived from the cytotoxic effects of antineoplastic therapy. Methods: This review followed the PRISMA 2020 guidelines. A search was conducted in PubMed, Scopus, Web of Science, Embase, and OpenGrey. Articles published before 23 July 2024, were included. Randomized controlled trials (RCTs) that included patients with head and neck cancer undergoing chemotherapy and/or radiotherapy and a placebo group compared to an intervention group (PBM) were selected. The risk of bias was evaluated using the Joanna Briggs Institute tools. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach and was rated as moderate. Results: A total of 3 RCTs and 229 patients were included. PBM may represent an additional cost in the short term, but the incremental expenses derived from the cytotoxic effects of antineoplastic therapy are greater in the medium–long term. The intervention group (PBM) showed a lower incidence of severe OM compared to the control group (placebo). Conclusions: PBM is a cost-effective long-term treatment, effective in preventing severe OM and improving the quality of life of cancer patients. More RCTs following the same standardized protocols are needed (registration CDR42024498825).
The Effectiveness of NP001 on the Long-Term Survival of Patients with Amyotrophic Lateral Sclerosis
Authors: Forrest Bruce D. , Goyal Namita A. , Fleming Thomas R. , Bracci Paige M. , Brett Neil R. , Khan Zaeem , Robinson Michelle , Azhir Ari , McGrath Michael
Published: October 2024

Background/Objectives: The aim of this study was to estimate the effect of a 6 months’ treatment course of the innate immune modulator NP001 (a pH-adjusted intravenous formulation of purified sodium chlorite), on disease progression, as measured by overall survival (OS) in patients with amyotrophic lateral sclerosis. Methods: Blinded survival data were retrospectively collected for 268 of the 273 patients who had participated in two phase 2 placebo-controlled clinical trials of NP001 (ClinicalTrials.gov: NCT01281631 and NCT02794857) and received at least one dose of either 1 mg/kg or 2 mg/kg of NP001 as chlorite based on actual body weight, or placebo. Kaplan–Meier methods were used on the intent-to-treat population to estimate survival probabilities. Results: In the overall population, the median OS was 4.8 months (2.7 years [95% CI: 2.3, 3.5] in the 2 mg/kg NP001group and 2.3 years [95% CI: 1.8, 2.9] in the placebo group). Hazard ratio (HR): 0.77 (95% CI: 0.57, 1.03), p = 0.073. Among patients aged ≤ 65 years, the median OS for the 2 mg/kg NP001 group was 10.8 months (3.3 years [95% CI: 2.4, 3.8] in the 2 mg/kg NP001 group and 2.4 years [95% CI: 1.7, 3.3] in the placebo group). HR: 0.69 (95% CI: 0.50, 0.95). No differences were observed in the 1 mg/kg NP001 group or in patients aged > 65 years. Conclusions: The findings from this study suggest that a 6 months’ treatment course of NP001 resulted in a 4.8-month increase in overall survival in patients with ALS. The findings from this study indicate that targeting inflammation associated with the innate immune system may provide a pathway for new therapeutic options for the treatment of ALS.
Bionic Multi-Legged Robots with Flexible Bodies: Design, Motion, and Control
Authors: Li Xiang , Suo Zhe , Liu Dan , Liu Jianfeng , Tian Wenqing , Wang Jixin , Wang Jianhua
Published: October 2024

Bionic multi-legged robots with flexible bodies embody human ingenuity in imitating, learning, and exploring the natural world. In contrast to rigid-body robots, these robots with flexible bodies exhibit superior locomotive capabilities. The flexible body of the robot not only boosts the moving speed and walking stability but also enhances adaptability across complex terrains. This article focuses on the innovative design of flexible bodies. Firstly, the structural designs, including artificial spines and single/multi-axis articulation mechanisms, are outlined systematically. Secondly, the enhancement of robotic motion by flexible bodies is reviewed, examining the impact that body degrees of freedom, stiffness, and coordinated control between the body and limbs have on robotic motion. Thirdly, existing robotic control methods, organized by control architectures, are comprehensively overviewed in this article. Finally, the application prospects of bionic multi-legged robots with flexible bodies are offered, and the challenges that may arise in their future development are listed. This article aims to serve as a reference for bionic robot research.
SDBS-AEO Mixture for Triton X-100 Replacement: Surface Activity and Application in Biosensors
Authors: Li Zhenzhen , Wang Lei , Tang Mengjie , Sun Yulong , Zhang Li , Chen Zhongxiu
Published: October 2024

Triton X-100 (TX-100) is a commonly used surfactant in the manufacture of biosensors. The factors limiting the use of TX-100 in biosensors are environmental concerns. In this study, the binary system of sodium dodecyl benzene sulfonate (SDBS) and fatty alcohol-polyoxyethlene ether (AEO) was investigated from the physicochemical principle of surfactant interaction and its application in biosensors. The results demonstrated that a mixture of SDBS and AEO at an appropriate molar ratio had a comparable activity to TX-100 in terms of surface activity, micelle formation, dynamic adsorption, foaming, emulsifying, and cell permeability. Theory and experimentation support the idea that SDBS-AEO might take the place of TX-100 in the manufacturing of biosensors. This study contributes to the development of alternatives to TX-100 and provides a new perspective for an in-depth study of the interaction mechanism of additives in biosensor design.
Pioneering Augmented and Mixed Reality in Cranial Surgery: The First Latin American Experience
Authors: Ramírez Romero Alberto , Rodríguez Herrera Andrea Rebeca , Sánchez Cuellar José Francisco , Cevallos Delgado Raúl Enrique , Ochoa Martínez Edith Elizabeth
Published: October 2024

Introduction: Augmented reality (AR) and mixed reality (MR) technologies have revolutionized cranial neurosurgery by overlaying digital information onto the surgical field, enhancing visualization, precision, and training. These technologies enable the real-time integration of preoperative imaging data, aiding in better decision-making and reducing operative risks. Despite challenges such as cost and specialized training needs, AR and MR offer significant benefits, including improved surgical outcomes and personalized surgical plans based on individual patient anatomy. Materials and Methods: This study describes three intracranial surgeries using AR and MR technologies at Hospital Ángeles Universidad, Mexico City, in 2023. Surgeries were performed with VisAR software 3 version and Microsoft HoloLens 2, transforming DICOM images into 3D models. Preoperative MRI and CT scans facilitated planning, and radiopaque tags ensured accurate image registration during surgery. Postoperative outcomes were assessed through clinical and imaging follow-up. Results: Three intracranial surgeries were performed with AR and MR assistance, resulting in successful outcomes with minimal postoperative complications. Case 1 achieved 80% tumor resection, Case 2 achieved near-total tumor resection, and Case 3 achieved complete lesion resection. All patients experienced significant symptom relief and favorable recoveries, demonstrating the precision and effectiveness of AR and MR in cranial surgery. Conclusions: This study demonstrates the successful use of AR and MR in cranial surgery, enhancing precision and clinical outcomes. Despite challenges like training and costs, these technologies offer significant benefits. Future research should focus on long-term outcomes and broader applications to validate their efficacy and cost-effectiveness in neurosurgery.
Overcoming Graft Rejection in Induced Pluripotent Stem Cell-Derived Inhibitory Interneurons for Drug-Resistant Epilepsy
Authors: Beaudreault Cameron P. , Wang Richard , Muh Carrie Rebecca , Rosenberg Ashley , Funari Abigail , McGoldrick Patty E. , Wolf Steven M. , Sacknovitz Ariel , Chung Sangmi
Published: October 2024

Background: Cell-based therapies for drug-resistant epilepsy using induced pluripotent stem cell-derived inhibitory interneurons are now in early-phase clinical trials, building on findings from trials in Parkinson’s disease (PD) and Huntington’s disease (HD). Graft rejection and the need for immunosuppressive therapy post-transplantation pose potential barriers to more epilepsy patients becoming potential candidates for inhibitory interneurons transplantation surgery. Objectives: The present literature review weighs the evidence for and against human leukocyte antigen (HLA)-mediated graft rejection in PD and HD and examines the potential advantages and drawbacks to five broad approaches to cell-based therapies, including autologous cell culture and transplantation, in vivo reprogramming of glial cells using viral vectors, allogeneic transplantation using off-the-shelf cell lines, transplantation using inhibitory interneurons cultured from HLA-matched cell lines, and the use of hypoimmunogenic-induced pluripotent stem cell-derived inhibitory interneurons. The impact of surgical technique and associated needle trauma on graft rejection is also discussed. Methods: Non-systematic literature review. Results: While cell-based therapies have enjoyed early successes in treating a host of central nervous system disorders, the immunologic reaction against surgical procedures and implanted materials has remained a major obstacle. Conclusions: Adapting cell-based therapies using iPSC-derived inhibitory interneurons for epilepsy surgery will similarly require surmounting the challenge of immunogenicity.
A Holistic View of Asphalt Binder Aging under Ultraviolet Conditions: Chemical, Structural, and Rheological Characterization
Authors: Zheng Qi , He Peikai , Zhang Dan , Weng Yuxin , Lu Jie , Wang Tao
Published: October 2024

Asphalt, as a key binder material in road construction, is susceptible to ultraviolet (UV) radiation-induced aging, leading to embrittlement and reduced durability. Despite the significance of UV aging, research in this area remains limited compared to that on thermal aging. This paper comprehensively reviews the current state of research on UV aging in asphalt, focusing on its mechanism, evaluation indicators, and methods to delay or avoid UV aging. The structural components, rheological properties, and aging mechanisms of asphalt are discussed. Various UV aging simulation methods, including the use of UV chambers and accelerated aging tests, are presented along with their evaluation tests such as dynamic shear rheometry, rutting tests, Fourier infrared spectroscopy, and bending beam rheology. Key indicators used to assess UV aging, including physical properties, rheological parameters, and chemical composition changes, are summarized. The mechanisms underlying UV aging, particularly the changes in asphalt’s structural components and rheological properties, are examined. The impact of factors like radiation intensity, temperature, chemical composition, and asphalt film thickness on UV aging is discussed. Additionally, various additives and modifiers, including modified bitumen, UV shielding agents, UV absorbers, antioxidants, and nanomodifiers, are reviewed for their potential to mitigate UV aging. This paper concludes by highlighting the challenges in developing standardized test equipment and evaluation criteria, the limitations of organic modifiers, and the need for further research on nanomaterials to improve asphalt’s UV aging resistance.
Ordered Mesoporous Nitrogen Dope Carbon Synthesized from Aniline for Stabilization of Ruthenium Species in CO2 Hydrogenation to Formate
Authors: Haider Arsalan , Masudi Ahmad , Ahn Sunghee , Park Kwangho , Lee Kyung Rok , Jung Kwang-Deog
Published: October 2024

The hydrogenation of CO2 to produce formic acid has garnered increasing interest as a means to address climate change and promote the hydrogen economy. This research investigates the nanocasting technique for the synthesis of ordered mesoporous nitrogen-doped carbon (MNC-An). KIT-6 functioned as the silica template, while aniline served as the nitrogen–carbon precursor. The resultant MNC-An exhibits cubic Ia3D geometry, possesses significant mesoporosity, and has a high nitrogen content, which is essential for stabilizing ruthenium single atoms. The catalyst exhibited a specific activity of 252 mmolFAgcat−1 following a 2 h reaction at 120 °C. Moreover, the catalyst exhibited exceptional relative activity during five recycling experiments while preserving its catalytic efficacy. The atomically dispersed ruthenium and its Ru3+ oxidation state demonstrated perseverance both before and after the treatment. The results indicated that the synthesized catalyst possesses potential for the expedited commercialization of CO2 hydrogenation to produce formic acid. The elevated carbon yield, along with excellent thermal stability, renders it a viable substrate for attaching and stabilizing atomically dispersed ruthenium catalysts.