bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanism-based Pharmacological Management of Chemotherapy-induced Neuropathic
Pain from Preclinical Studies to Clinical Prospective: Platinum-based Drugs,
Taxanes, and Vinca Alkaloids
Authors: Zafari Nima , Velayati Mahla , Maftooh Mina , Khazaei Majid , Nassiri Mohammadreza , Hassanian Seyed M. , Ghayour-Mobarhan Majid , Ferns Gordon A. , Avan Amir
Published: May 2023

Background:

Chemotherapy-induced peripheral neuropathy (CIPN) is a painful condition, experienced
by patients undergoing chemotherapy with some specific drugs, such as platinum-based agents, taxanes,
and vinca alkaloids. Painful CIPN may lead to dose interruptions and discontinuation of chemotherapy and can
negatively impact on the quality of life and clinical outcome of these patients. Due to a lack of a practical medical
therapy for CIPN, it is necessary to further explore and identify novel therapeutic options.

Methods:

We have reviewed PubMed and EMBASE libraries to gather data on the mechanism-based pharmacological
management of chemotherapy-induced neuropathic pain.

Results:

This review has focused on the potential mechanisms by which these chemotherapeutic agents may be
involved in the development of CIPN, and explains how this may be translated into clinical management. Additionally,
we have presented an overview of emerging candidates for the prevention and treatment of CIPN in
preclinical and clinical studies.

Conclusion:

Taken together, due to the debilitating consequences of CIPN for the quality of life and clinical
outcome of cancer survivors, future studies should focus on identifying underlying mechanisms contributing to
CIPN as well as developing effective pharmacological interventions based on these mechanistic insights.
Moxifloxacin: Physical-chemical and Microbiological Analytical Methods in the
Context of Green Analytical Chemistry
Authors: da Silva Thaisa Alves Celedonio , Lustosa Isadora Alves , Kogawa Ana Carolina
Published: May 2023

Moxifloxacin (MOX) is a fourth-generation fluoroquinolone used in the form of tablets, infusion solutions
and ophthalmic solutions. It does not have a physical-chemical or microbiological analytical method described
in an official compendium. However, the literature shows some analysis methods for pharmaceuticals
and biological matrices. In this context, the objective is to show the analytical methods present in the literature
for the investigation of MOX by physical-chemical and microbiological techniques, as well as discussing them
according to the requirements of current pharmaceutical analyses and green analytical chemistry. Among the
physical-chemical methods present in the literature for MOX evaluation, 33% are HPLC, 21% are UV-Vis and
17% are capillary electrophoresis. On the other hand, among the microbiological methods, all of them are based
on diffusion in agar. There is still scope in the literature to incorporate new and improved analytical methods
for MOX evaluation, which adopt the concepts of green and sustainable analytical chemistry, either by using
less (or not using) toxic organic solvents, reducing waste generation or even reducing the analysis time according
to the intended objectives.
Study on the Interaction between Silibinin and Neuraminidase
Authors: Fang Haowen , Ding Yanting , Lu Yi , Niu Bing , Lu Han , Chen Qin
Published: May 2023

Background:

Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies
have shown that silibinin has the potential to inhibit neuraminidase activity.

Objective:

This study aims to explore the interaction between silibinin and neuraminidase and the effect of
silibinin on the structure and activity of neuraminidase.

Methods:

In this study, two-dimensional fluorescence spectrum, three-dimensional fluorescence spectrometry,
Uv-vis spectroscopy, and Circular dichroism analysis were used.

Results:

Silibinin alters the secondary structure of neuraminidase and inhibits the activity of neuraminidase.

Conclusion:

Silibinin can interact with neuraminidase and inhibit its activity.
Narrative Review of the Pharmacodynamics, Pharmacokinetics, and Toxicities
of Illicit Synthetic Cannabinoid Receptor Agonists
Authors: Lea Houston Matilda , Morgan Jody , Kelso Celine
Published: May 2023

Background:

Synthetic cannabinoid receptor agonists (SCRAs) are the most diverse
class of new psychoactive substances worldwide, with approximately 300 unique SCRAs identified
to date. While the use of this class of drug is not particularly prevalent, SCRAs are associated with
several deaths every year due to their severe toxicity.

Methods:

A thorough examination of the literature identified 15 new SCRAs with a significant clinical
impact between 2015 and 2021.

Results:

These 15 SCRAs have been implicated in 154 hospitalizations and 209 deaths across the
US, Europe, Asia, and Australasia during this time period.

Conclusion:

This narrative review provides pharmacodynamic, pharmacokinetic, and toxicologic
data for SCRAs as a drug class, including an in-depth review of known pharmacological properties
of 15 recently identified and emerging SCRAs for the benefit of researchers, policy makers, and
clinicians who wish to be informed of developments in this field.
Advances in Medicinal Chemistry of Estrogen-related Receptor Alpha
(ERRα) Inverse Agonists
Authors: Zhang Haibin , Du Yongli , Zheng Yong , Lv Huiting , Yan Zhijia , Dong Ning , Zhu Yaling , Shen Jingkang
Published: May 2023

Estrogen-related receptor alpha (ERRα), a member of the nuclear receptor superfamily, is strongly expressed in breast cancer cells. Its overexpression is associated with poor prognosis in tri-ple-negative breast cancer (TNBC). ERRα expression could be inhibited by the downregulation of upstream oncogenic growth factors mTOR, HER2, and PI3K. Low expression of ERRα could sup-press the migration and angiogenesis of tumor cells by inhibiting the activity of its downstream sig-nals VEGF and WNT11. Studies have confirmed that ERRα inverse agonists can inhibit ERRα ex-pression to treat breast cancer. Inverse agonists of ERRα could disrupt the interactions of ERRα with its coactivators and inhibit tumor development. Existing ERRα inverse agonists have shown moderate efficacy in inhibiting the growth of breast cancer cells. Clinical inverse agonists of ERRα have not been found in the literature. This review focuses on the research progress and the structure-activity relationship of ERRα inverse agonists, providing guidance for the research and discovery of new anti-tumor compounds for TNBC.
Reversible Intracranial Cytotoxic Edema Associated with COVID-19: A Case
Report
Authors: Çakmakci Güngör , Çeti̇ner Mustafa , Akdağ Gönül , Arikan Fatma Akkoyun , Kabay Sibel Canbaz
Published: May 2023

Background:

It is well-known that COVID-19 causes pneumonia and acute respiratory distress syndrome, as well as pathological neuroradiological imaging
findings and various neurological symptoms associated with them. These include a range of neurological diseases, such as acute cerebrovascular
diseases, encephalopathy, meningitis, encephalitis, epilepsy, cerebral vein thrombosis, and polyneuropathies. Herein, we report a case of reversible
intracranial cytotoxic edema due to COVID-19, who fully recovered clinically and radiologically.

Case Report:

A 24-year-old male patient presented with a speech disorder and numbness in his hands and tongue, which developed after flu-like symptoms. An
appearance compatible with COVID-19 pneumonia was detected in thorax computed tomography. Delta variant (L452R) was positive in the
COVID reverse-transcriptase polymerase chain reaction test (RT-PCR). Cranial radiological imaging revealed intracranial cytotoxic edema, which
was thought to be related to COVID-19. Apparent diffusion coefficient (ADC) measurement values in the magnetic resonance imaging (MRI)
taken on admission were 228 mm2/sec in the splenium and 151 mm2/sec in the genu. During the follow-up visits of the patient, epileptic seizures
developed due to intracranial cytotoxic edema. ADC measurement values in the MRI taken on the 5th day of the patient's symptoms were 232
mm2/sec in the splenium and 153 mm2/sec in the genu. ADC measurement values in the MRI taken on the 15th day were 832 mm2/sec in the
splenium and 887 mm2/sec in the genu. He was discharged from the hospital on the 15th day of his complaint with a clinical and radiological
complete recovery.

Conclusion:

Abnormal neuroimaging findings caused by COVID-19 are quite common. Although not specific to COVID-19, cerebral cytotoxic edema is one of
these neuroimaging findings. ADC measurement values are significant for planning follow-up and treatment options. Changes in ADC values in
repeated measurements can guide clinicians about the development of suspected cytotoxic lesions. Therefore, clinicians should approach cases of
COVID-19 with CNS involvement without extensive systemic involvement with caution.
Strength of Deep Learning-based Solutions to Secure Healthcare IoT: A Critical Review
Authors: Mathew Arul Treesa , Mani Prasanna
Published: May 2023

Healthcare applications of IoT systems have gained huge popularity across the globe. From personal monitoring to expert clinical diagnosis, healthcare IoT systems have shown their importance to all possible extents. The ease of use and precise results add to the wide acceptance of such systems. However, this has also led to a magnificent increase in the number of attacks aimed at stealing or manipulating data as well as operations of HIoT-based healthcare assistance. Among the various modes of attacks, network-based attacks are found in the majority. In this work, we perform a critical review of these attacks, the existing countermeasures, and their limitations to understand and proclaim the importance of securing healthcare networks in the best possible manner. We also emphasize the necessity of deep learning-based smart solutions for securing healthcare systems, understanding the potential of deep learning in the security aspects being deployed in other genres of IoT applications. A comparative analysis of deep learning and machine learning-based security solutions is performed to examine their performances.
THE ROLE OF THE UNITED NATIONS HIGH COMMISSIONER FOR REFUGEES (UNHCR) IN HANDLING FOREIGN REFUGEES
Authors: Mahira Gina
Published: May 2023

This study is to discuss the role of the UNHCR in Cisarua District, Bogor in 2021-2022 using role theory by Clive Archer which classifies the role of international organizations as instruments, arenas, and independent actors. The method used in this research is descriptive qualitative method with data collection from primary and secondary data. The data collection is done by interview and documentation process. In this research, the writer analyzes the data by collecting various data, sorting and filtering, and linking it with the chosen theory. The result of this research is the role of UNHCR in dealing with refugees in Cisarua District is as an instrument. This role can be seen from the UNHCR whose main objective is to provide protection and assistance and asylum status to refugees in this case can be carried out. However, this role has not yet been fully implemented.Keywords: Cisarua District, refugees, role, UNHCR
Family role in preserving Javanese culture, values, and language: The challenges in the globalization 4.0 era
Authors: Jannah Nita Maghfiratul , Lestari Kurnia , Jhonathan Gregorius , Pinilih Murni Sekar , Nurhayati Ari , Margana Margana
Published: May 2023

Along with the rise of the impact of globalization 4.0 that blurs the boundaries between countries and competition at the world level, many indigenous cultures have been pushed aside. Many families consider other cultures to be more advanced and educate children in contemporary culture that does not reflect their cultural identity. Efforts to preserve the nation's original culture need to be carried out from the family level. This quantitative study was aimed at determining factors influencing children's language development and the role of the family and the challenges in the effort of preserving Javanese culture, values, and languages in the globalization 4.0 era. The population of the study was the family whose kid around 3-12 years old domicile in Central Java and Yogyakarta. In total 94 samples were chosen using a random purposive  method.    The data were gathered  using  questionnaires  then analyzed  using  a descriptive quantitative  method.  The result  of the study  shows  that  family  roles  impact children's acquisition of Javanese. Environment, language level or social strata in language, media, and parental inability are the most common reasons why Javanese is considered difficult. This article also suggests solutions and gives other related data to support this study
Dampak pembelajaran penjas dengan workout exercise terhadap tingkat kebugaran jasmani siswa
Authors: Sriwidaningsih Raden Roro , Hadiansyah Diky , Nugraha Alvin Gunardi
Published: May 2023

Penelitian ini bertujuan untuk mengetahui dampak pembelajaran penjas dengan workout exercise terhadap tingkat kebugaran jasmani siswa. Penelitian ini menggunakan metode penelitian Poor Experimen dengan desain One Group Pre Test Post Test. Adapun populasi dalam penelitian ini yaitu siswa kelas XI MIPA SMA Negeri 1 Plered yang berjumlah 165 orang. Sampel dalam penelitian ini adalah siswa kelas XI MIPA 5 yang berjumlah 27 orang. Instrumen yang digunakan dalam penelitian ini adalah Indiana Physical Fitness Test yang terdiri dari: Straddle Chins, Squat Thrust, Push Up, dan Squat Jump. Berdasarkan hasil penelitian terlihat bahwa adanya peningkatan dari nilai pre-test pada nilai post-test terhadap tes kebugaran jasmani menggunakan Indiana Physical Fitness Test. Hasil tersebut dibuktikan dengan hasil analisis uji-t yang dibantu dengan program analisis data SPSS 25 dengan nilai probabilitas 0,000, karena 0,000 0,05 maka Ha diterima dan H0 ditolak. Hasil tersebut menunjukan adanya peningkatan nilai hasil dari pre-test terhadap nilai hasil post-test kebugaran jasmani siswa. Hal itu mendasari pengambilan keputusan yang menyatakan bahwa ada perbedaan peningkatan kebugaran jasmani siswa setelah diberikan perlakuan yaitu pembelajaran pendidikan jasmani dengan Workout Exercise. Penelitian yang dilakukan dapat menjadi bahan pertimbangan bahwa aplikasi home workout dapat dijadikan media pembelajaran penjas dalam upaya meningkatkan kebugaran jasmani siswa. This study aims to determine the impact of physical education learning with workout exercises on the level of physical fitness of students. This study uses the Poor Experiment research method with the One Group Pre Test Post Test design. The population in this study were 165 students of class XI MIPA SMA Negeri 1 Plered. The sample in this study were students of class XI MIPA 5 totaling 27 people. The instrument used in this research is the Indiana Physical Fitness Test which consists of: Straddle Chins, Squat Thrust, Push Up, and Squat Jump. Based on the results of the study, it can be seen that there is an increase in the pre-test scores on the post-test scores on physical fitness tests using the Indiana Physical Fitness Test. These results are evidenced by the results of the t-test analysis assisted by the SPSS 25 data analysis program with a probability value of 0.000, because 0.000 0.05 then Ha is accepted and H0 is rejected. These results indicate an increase in the value of the results of the pre-test on the value of the post-test results of students' physical fitness. This underlies the decision making which states that there is a difference in the improvement of students' physical fitness after being given treatment, namely physical education learning with Workout Exercise. The research conducted can be taken into consideration that home workout applications can be used as physical education learning media in an effort to improve students' physical fitness.
Learning Innovation through Teaching Game for Understanding (TGfU) Model to Prepare Physical Education Learning Strategy Skills
Authors: Sumarno Sumarno , Imawati Veni , Ristiawan Bayu
Published: May 2023

Abstrak: Karakteristik dari pembelajaran Pendidikan Jasmani (Penjas) yang condong pada aktivitas luar ruangan membutuhkan desain dan strategi khusus. Salah satu desain pembelajaran yang dapat menjadi alternatif adalah model Teacging Game for Understanding (TGfU). Tujuan penelitian ini untuk mendeskripsikan pengembangan, kegunaan dan persepsi guru dalam mengimplementasikan bahan ajar Penjas berbasis permainan dengan model TGfU. Penelitian dan pengembangan ini menggunakan model ADDIE (analyze, design, develop, implement evaluate). Uji coba produk terdiri penilaian oleh ahli dan uji coba lapangan melalui evaluasi formatif (One-to-one, small-group field trial) yang dilakukan oleh 10 partisipan. Instrumen yang digunakan meliputi protokol wawancara, observasi dan dokumentasi. Analisis data kualitatif menggunakan bantuan softwere qualitative data analysis Atlas.Ti versi 9. Desain permainan model TGfU dikembangkan yang didasarkan pada tingkat pengetahuan guru, karakteristik siswa dan sumber daya. Salah satu temuan penting dari proses RD ini bahwa baik guru maupun siswa membutuhkan waktu yang lebih untuk mempelajari cara kerja dari model TGfU. Secara prospektif, desain yang kami kembangakan menjanjikan untuk digunakan sebagai strategi pembelajaran Penjas di masa depan. Abstract: Characteristics of Physical Education (PE) that are inclined to outdoor activities require special designs and strategies. One of the learning designs that can be an alternative is the Teaching Game for Understanding (TGfU) model. The purpose of this study was to describe the development, usability, and perception of teachers in implementing game-based Physical Education teaching materials with the TGfU model. This research and development use the ADDIE model (analyze, design, develop, implement evaluate). The product trial consisted of an expert assessment and a field trial through formative evaluation (one-to-one, small-group field trial) conducted by 10 participants. The instruments used include interview protocols, observation, and documentation. Qualitative data analysis using qualitative data analysis software Atlas.Ti version 9. The TGfU model game design was developed based on the level of teacher knowledge, student characteristics, and resources. One of the important findings from this RD is both teachers and students need more time to learn how the TGfU model works. Prospectively, the design we have developed is promising to be used as a strategy for learning Physical Education in the future.
A Reasonable Period of Criminal Proceedings: the Emergence of the Principle, the Practice of its Implementation and the Impact of the ECHR
Authors: Chistilina D. O. , Delova A. D.
Published: May 2023

Relevance. The article examines the legal norms in the field of implementation of the principle of a reasonable period of criminal proceedings. There are some contradictions in Russian legislation on this issue, and as practice shows, this principle is not observed in the proceedings in many cases. The theory of criminal procedure has not yet developed a clear mechanism to fully implement the operation of this principle.

The purpose of the research is to analyze the substance of criminal procedural norms regulating the principle of a reasonable period of criminal proceedings at the theoretical and practical levels.

The objectives of the research: to investigate the norms regulating the principle of a reasonable period of criminal proceedings, the prerequisites and history of its appearance and development, as well as to determine its significance in domestic legal science; to analyze in detail Article 6.1 of the Code of Criminal Procedure of the Russian Federation and to consider the relevant judicial practice.

The methodology of the research is presented by the dialectical method, the comparative legal method, historical and special legal methods.

Results. In the course of the research, some problems were identified in the implementation in practice of the principle of a reasonable period of criminal proceedings and compensation for violation of this norm. The theoretical essence and content of this principle are analyzed. Based on the results of the research, proposals were developed and formulated to improve legislation in this area.

Conclusion. According to the results of the research, conclusions are drawn about the interdisciplinarity of the principle of a reasonable period of criminal proceedings, since it is guaranteed by compensation within the framework of civil, not criminal proceedings. It is rightly noted that for each case, its own period of production will be recognized as reasonable, and the decisive word on its determination belongs only to the court. It is also concluded that if the criminal proceedings have clearly taken on a protracted nature, then the sheer complexity of the case itself cannot justify the overall duration of the criminal proceedings.
Actual Problems of Qualification of Unlawful Impact on the Critical Information Infrastructure of the Russian Federation
Authors: Malygin I. I.
Published: May 2023

Relevance. Protection of objects of critical information infrastructure is an urgent task of ensuring the information security of the state. This problem acquired particular significance during the period of the special military operation in Ukraine - during this time the number of computer attacks on the domestic information infrastructure has increased many times over. For several years, the application of Art. 274.1 of the Criminal Code of the Russian Federation is characterized by consistent growth. The study of judicial and investigative practice indicates the presence of legal and technical shortcomings of the norm and problems associated with its application.

The purpose is to obtain new scientific knowledge about the implementation of the mechanism of criminal law protection of the critical information infrastructure of the Russian Federation, to substantiate proposals aimed at overcoming the difficulties that arise in the application Art. 274.1 of the Criminal Code of the Russian Federation.

Objectives: to identify the problems of qualifying unlawful impact on critical information infrastructure facilities, to formulate proposals for improving domestic criminal legislation and law enforcement.

Methodology. The methodological base of the research is made up of general scientific and particular scientific methods of cognition of reality, such as analysis, synthesis, induction, formal-legal, abstract-logical and others.

Results. The study analyzed data from judicial statistics, law enforcement practice in cases of unlawful impact on the critical information infrastructure of the Russian Federation, studied doctrinal sources and analytical materials.

Conclusions. The following provisions are formulated and substantiated in the work: 1) at the moment, the main direction of implementation Art. 274.1 of the Criminal Code of the Russian Federation is its application in cases of violation of the rules for the operation of computer information storage facilities by employees of companies providing services in the field of communications (telecom operators); 2) at the level of judicial and investigative practice, there is a discrepancy in the interpretation of socially dangerous consequences in the form of harm to an object of the critical information infrastructure of the Russian Federation.; 3) it should be recognized as erroneous in practice the decision to qualify the deed under Part 1 of Art. 274.1 of the Criminal Code of the Russian Federation in situations
To the Issue of the Reasons for the Transition to a New Economic Policy
Authors: Kolupaev A. A.
Published: May 2023

Relevance. The author in the article proves the scientific opinion that the main reason that forced the Bolsheviks to abandon the very effective policy of war communism, in their opinion, was precisely the Kronstadt rebellion. The uprising in Kronstadt created real conditions for the loss of power by the Bolsheviks. The large-scale military protest was an unexpected phenomenon for the Bolsheviks and forced them to temporarily abandon their domestic political course.

The purpose of this study is to examine the reasons for the transition to a new economic policy.

Objectives The main objectives of this scientific study are: to analyze the historical conditions in which Soviet Russia found itself at the end of the Civil War; study of the main reasons for the country's transition to a new economic policy.

Methodology The main objectives of this scientific study are: to analyze the historical conditions in which Soviet Russia found itself at the end of the Civil War; study of the main reasons for the country's transition to a new economic policy.

Results became objective evidence that it was the social protest, which manifested itself in the form of peasant revolts throughout the country, and most importantly the Kronstadt uprising, that became the main reason for the Bolsheviks to switch to a new economic policy.

Conclusion Thus, by the end of 1920, Soviet Russia was actually devastated due to the ongoing civil conflict for several years, as well as as a result of the economic policy of the Bolsheviks. Having achieved a military victory over their main political opponents, the Bolsheviks were going to continue the economic course - the policy of war communism, which helped them win the Civil War. However, the population of the country was not at all going to be consumables for the economic experiments of the Bolshevik Party. It showed its sharp dissatisfaction with the economic course pursued in the country in large-scale peasant uprisings throughout the country and in the armed uprising of sailors and soldiers in Kronstadt. These circumstances forced the leader of the Bolshevik Party V.I. Lenin to abandon the course towards the accelerated construction of communism and move on to a new economic policy.
Kursk Fortress: on the Question of the Boundaries and Appearance of the Znamensky Monastery
Authors: Petrov A. A.
Published: May 2023

Relevance. This article is an attempt to compare the changes in the stone architectural ensemble of the Znamensky Monastery in the period from the second half of the XVII century to the beginning of the XIX century. This topic has been little studied, and therefore it is relevant and in demand.

The purpose is to determine the boundaries and appearance of the Kursk Znamensky Monastery from the moment of its foundation until the beginning of the XIX century on the basis of available materials.

Objectives: to compare the location of the monastery buildings with the modern urban relief and to establish the type of buildings.

Methodology. The article is based on the principles of historicism, scientific objectivity and consistency, which are supplemented by the method of reconstruction, the comparative historical method. In the work, among other things, the technique of virtual 3d modeling is used.

Results. By superimposing city plans of different times and modern satellite images, the possible location of the buildings of the Znamensky Monastery is determined, its appearance of buildings is described. It is established that the appearance of the "Kursk Kremlin" has been constantly changing during the time of its existence. Comparing the boundaries of the foundations and studying the principles of construction of similar structures with the preserved images of the monastery allowed us to recreate the boundaries and appearance of the Kursk shrine. Thanks to the 3d modeling technique, the architectural appearance of the ensemble of the Znamensky Monastery of the XVII – XVIII centuries has been recreated.

Conclusion. The conducted research gave grounds to assert that the architectural Znamensky Monastery has been the "axis" of urban development since its foundation. Its appearance was, on the one hand, typical of the temples of medieval Russia, on the other, Kursk stood out from many other Russian cities.
Principles of State Administration for the Security and Protection of the Vital Interests of the People
Authors: Pozdnyakova E. V.
Published: May 2023

Relevance. The systemic and legal problems of developing the unity of principles for managing the security and protection of the vital interests of the people are multifaceted, complex, and largely debatable. Both constitutional and administrative principles of security management, as well as their unity, primarily meet the interests of citizens and are aimed at ensuring the development of legal protection of life, rights and freedoms, since they prioritize in favor of a person. The unity of principles as scientific principles and the basic rules of behavior of subjects of management requires the development of security and the protection of the vital interests of the people, which is currently very important.

The purpose. Establishing the content of the constitutional and administrative principles of state management of the security and protection of the vital interests of the people.

Objectives: define regulatory legal acts containing the principles of public safety management; highlight the constitutional and administrative principles of state management of the security and protection of the vital interests of the people.

Methodology. The study used a combination of methods, such as: a general scientific method for studying legal phenomena and processes, formal legal and formal logical methods.

Results. In the course of the study, the constitutional and administrative principles of state management of the security and protection of the vital interests of the people were considered, as well as their unity, aimed at protecting the vital interests of a person, was studied.

Conclusion. The unity of the principles of state management of the security and protection of the vital interests of the people gives a scientific idea of the procedure for generalizing and extending each principle to the activities of a state authority and local self-government, aimed at fulfilling the obligations of the state to create safe living conditions for its citizens, including their implementation. constitutional rights and freedoms.
Association Between VDR and CYP24A1 Polymorphisms, Atopic Dermatitis, and Biochemical Lipid and Vitamin D Profiles in Spanish Population: Case-Control Study
Authors: González-Tarancón Ricardo , Goñi-Ros Nuria , Salvador-Rupérez Elvira , Hernández-Martín Ángela , Izquierdo-Álvarez Silvia , Puzo-Foncillas José , Gilaberte-Calzada Yolanda
Published: May 2023

Background

Atopic dermatitis (AD) is the most prevalent inflammatory skin disorder, characterized by impaired epidermal barrier function and an altered immune response, both of which are influenced by vitamin D deficiency. Single-nucleotide polymorphisms (SNPs) in VDR and CYP24A1 have been previously associated with AD.

Objective

We sought to characterize the associations between the VDR and CYP24A1 polymorphisms and the vitamin D and lipid biochemical profile in children diagnosed with AD.

Methods

A total of 246 participants (143 patients with AD and 103 healthy controls) were enrolled in this study. Genotyping for polymorphisms in VDR (rs2239185, rs1544410, rs7975232, rs2238136, rs3782905, rs2239179, rs1540339, rs2107301, rs2239182, and rs731236) and CYP24A1 (rs2248359 and rs2296241) was performed by allele-specific polymerase chain reaction using integrated fluidic circuit technology. Serum levels of calcium, phosphorus, and vitamin D were measured, and the biochemical lipid profile was determined.

Results

Among VDR SNPs, rs2239182 exerted a protective effect against the development of AD, whereas rs2238136 was identified as a risk factor for AD. The GCC haplotype (rs2239185-G, rs1540339-C, and rs2238136-C) appeared to protect against the development of AD. rs2239182-CC was associated with higher 25(OH)D concentrations, whereas rs2238136-TT, rs2239185-GA, and rs2248359-TT were present in a large proportion of patients with serum vitamin D deficiency. rs2239185-AA, rs2239182-CC, and rs1540339-CC were associated with higher serum total cholesterol; rs2239182-TT was associated with lower low-density lipoprotein cholesterol; and rs2239182-TC with lower high-density lipoprotein cholesterol. Both CYP24A1 SNPs (rs2296241-AA and rs2248359-TT) were associated with higher high-density lipoprotein cholesterol levels.

Conclusions

The VDR SNP rs2238136 is a risk factor for AD and other SNPs in VDR and CYP24A1, which may lead to alterations in biochemical parameters that influence the risk of AD. Our findings highlight the complex genetic basis to AD and indicate that interrelationships between different genetic factors can lead to alterations in vitamin D metabolism or lipid profiles, which in turn may influence the development of AD.
Cardiac Rehabilitation Facebook Intervention: Feasibility Randomized Controlled Trial
Authors: Siegmund Lee Anne , Bena James F , Morrison Shannon L
Published: May 2023

Background

The adherence to cardiac rehabilitation is low. Social media has been used to improve motivation and cardiac rehabilitation completion, but the authors did not find Facebook interventions for these purposes in the literature.

Objective

The purpose of this study was to determine the feasibility of the Cardiac Rehabilitation Facebook Intervention (Chat) for affecting changes in exercise motivation and need satisfaction and adherence to cardiac rehabilitation.

Methods

The Behavioral Regulation in Exercise Questionnaire-3 and Psychological Need Satisfaction for Exercise were used to measure motivation and need satisfaction (competence, autonomy, and relatedness) before and after the Chat intervention. To support need satisfaction, the intervention included educational posts, supportive posts, and interaction with peers. The feasibility measures included recruitment, engagement, and acceptability. Groups were compared using analysis of variance and Kruskal-Wallis tests. Paired t tests were used to assess motivation and need satisfaction change, and Pearson or Spearman correlations were used for continuous variables.

Results

A total of 32 participants were lost to follow-up and 22 were included in the analysis. Higher motivation at intake (relative autonomy index 0.53, 95% CI 0.14-0.78; P=.01) and change in need satisfaction-autonomy (relative autonomy index 0.61, 95% CI 0.09-0.87; P=.02) were associated with more completed sessions. No between-group differences were found. Engagement included “likes” (n=210) and “hits” (n=157). For acceptability, mean scores on a 1 (not at all) to 5 (quite a bit) Likert scale for feeling supported and in touch with providers were 4.6 and 4.4, respectively.

Conclusions

Acceptability of the Chat group was high; however, intervention feasibility could not be determined due to the small sample size. Those with greater motivation at intake completed more sessions, indicating its importance in cardiac rehabilitation completion. Despite challenges with recruitment and engagement, important lessons were learned.

Trial Registration

ClinicalTrials.gov NCT02971813; https://clinicaltrials.gov/ct2/show/NCT02971813

International Registered Report Identifier (IRRID)

RR2-10.2196/resprot.7554
EVALUATION OF LIPID PROFILE AND LIVER FUNCTION PARAMETERS IN OBESE AND NON-OBESE HYPERTENSIVE INDIVIDUALS ATTENDED TERTIARY CARE TEACHING HOSPITAL
Authors: M. PRASAD RAO , JALEM SPURGEON RAJ , KUMAR BARLA BSV SATYA , SANGAM SMRUTI
Published: May 2023

Objective: In this study, lipid profile parameters and liver function parameters were measured and correlated in hypertensive obese and non-obese patients who were attended a tertiary care teaching hospital.

Methods: This study is a retrospective observational, cross-sectional study over the course of a year in a tertiary care hospital. All adult patients with hypertension, both obese and non-obese, are included in the study population. The study involved 150 participants in total, including obese and non-obese people (71 men and 79 women). Standard techniques were used to assess the serum levels of TG, TC, LDL, HDL, and liver enzymes such SGOT, SGPT, bilirubin, and ALP. Moreover, BMI was calculated for both study groups. The association between elevated lipid profile markers and liver enzyme abnormalities was assessed by correlation analysis.

Results: Out of 150 samples size comprises 75 obese and 75 non-obese individuals, 71 males and 79 females were reported in the current study. Our study gives very good association between lipid profiles to almost all LFT and the highest is shown between HDL, LDL and VLDL to all LFT. There was a high significant difference was noticed between the obese and non-obese individuals in relation to bilirubin (D) concentration, SGOT and SGPT between the two groups P<0.0001. The levels of albumin were lowered and the significant variations were noticed between the two groups. The mean values of cholesterol, LDL and triglycerides were very high in obese individuals than non-obese individuals and the HDL was lower in obese individuals.

Conclusion: The study found that liver function variables and abnormal lipid profiles were highly prevalent in obese hypertension patients. In participants with dyslipidemia, increased liver enzymes were seen more frequently.
Performance Evaluation Method Biology Learning Project as An Effective Teaching Tool
Authors: Nijat Ulya Shirinzada
Published: May 2023

The purpose of this study is to investigate the effect of project-based learning and thinking ability in biology classes. The research analyzed a sample of students from two distinct grades using pre-test and post-test. Following that, the findings revealed that members of the experimental group I, which included students who engaged in project-based, learning, had the best learning outcomes. In a project-based learning environment, students gained knowledge and skills by working collaboratively for an extended period on a real-world question or problem. Students trained using this model had better indicators of thinking ability than students trained using the traditional learning model. Thus, teachers must use the project-based learning model to guarantee better results while also improving students' thinking abilities to increase the model's efficacy. Schools can promote collaboration, agency, and effective communication skills by teaching social studies using project-based learning. PBL also allows students to address real-world issues in their community and around the globe.
A Study of the Revitalization of Indigenous People Annual Rituals in Taiwan
Authors: Chang Hsiao-Ming
Published: May 2023

Over the past 400 years, Taiwan's indigenous people annual rituals have been lost due to the assimilation of foreign regimes and the influence of modern urbanization. However, under the influence of modern social life style and political power, the annual rituals became performance and lost their original significance. But also because of its regeneration, the culture of Taiwan's indigenous people has been revitalized, and has the role of identity and continuity. However, because of the restoration of the annual rituals, the culture of the aborigines has been revitalized, and the role of recognition and continuity has been generated in Taiwan.
El régimen simplificado de confianza en la ley del impuesto sobre la renta y su lucha contra la informalidad
Authors: Ríos Granados Gabriela , Santos Flores Israel
Published: May 2023

El trabajo tiene como objetivo analizar la introducción y aplicación del denominado Régimen Simplificado de Confianza, que sustituye al régimen de incorporación fiscal (RIF) en la Ley del Impuesto sobre la Renta y vigente a partir de 2022. En este sentido, se hace una revisión crítica de dicho régimen desde la dogmática del derecho tributario, especialmente a partir de sus conceptos fundamentales cuestionando si persigue fines extrafiscales o si se trata de un régimen de economía de opción.
Factores jurídico-económicos para incorporar la multipropiedad o el tiempo compartido en el ordenamiento jurídico peruano
Authors: Rojas Ulloa Milushka
Published: May 2023

El objetivo de este artículo es determinar los factores jurídico-económicos más relevantes que permitan incorporar el sistema de multipropiedad o el sistema del tiempo compartido dentro del ordenamiento jurídico peruano, al surgir nuevas modalidades de viviendas turísticas y recreacionales ubicadas a lo largo del territorio peruano, sometidos a una norma interna que desnaturaliza su esencia al equiparla con una nueva modalidad de copropiedad. Para ello, hemos acudido a literatura especializada, estadísticas, encuestas y entrevistas que nos permitan ubicarnos en el punto intermedio estratégico que posibilite, por un lado, la seguridad que demandan los inversionistas, y por el otro, la protección que requieren los consumidores al adquirir dichos sistemas, considerando para ambas situaciones la necesaria supervisión de un organismo estatal, desde la constitución del sistema hasta su extinción.
Hacia una teoría sobre la e-justice o justicia digital: instrucciones para armar
Authors: Medina Zepeda Emmanuel
Published: May 2023

Uno de los tópicos que más han llamado la atención en los tiempos contemporáneos es la aplicación de la tecnología digital en la administración de justicia, lo que se denomina en el derecho anglosajón como e-justice. El presente estudio tiene por objeto ofrecer algunas de las piezas para el armado de una teoría sobre la e-justice. Este análisis recoge los temas de mayor relevancia sobre la aplicación de la tecnología digital a la administración de justicia, ya sea para adaptar los mecanismos actuales o para advertir los retos del futuro.
Waldron y la dignidad como estatus en el debate constitucional chileno
Authors: Gamonal C. Sergio
Published: May 2023

En este artículo analizaremos la noción de dignidad como estatus, planteada por Jeremy Waldron, y su relevancia en el debate constitucional chileno, centrándonos en el derecho laboral. La dignidad está consagrada en la mayoría de las constituciones del mundo, y la importancia de esta noción no está exenta de críticas, dada su ambivalencia. Sin embargo, la noción de Waldron permite precisar un sentido mínimo que es relevante en toda democracia contemporánea y que debiera guiar el actual proceso constituyente en Chile.
¿Una nueva guerra fría por otros medios? Las derivaciones del caso Skripal
Authors: Arredondo Ricardo
Published: May 2023

Este trabajo analiza las expulsiones recíprocas de diplomáticos entre Estados Unidos, Rusia y otros países occidentales con motivo de la intoxicación de un ex espía ruso, Sergei Skripal, y su hija,Yulia, ocurrida en el Reino Unido. Este tit for tat responde a un viejo patrón de conducta entre las potencias cuyo marco jurídico viene proporcionado, principal pero no exclusivamente, por las Convenciones de Viena sobre Relaciones Diplomáticas de 1961 y sobre Relaciones Consulares de 1963. Estas normas recogen los principios de consentimiento mutuo y de reciprocidad que gobiernan las relaciones diplomáticas y consulares entre Estados y establecen un régimen propio de normas secundarias para resolver los casos en que sus normas primarias son quebrantadas.
The Role of Non-Governmental Organizations in the Process of International Treaty Making
Authors: Giorgi Maiara
Published: May 2023

Las organizaciones no gubernamentales han desempeñado un papel importante en el escenario mundial. El crecimiento del número de ONG muestra que su importancia, influencia, representatividad y participación en la comunidad internacional es esencial, ya que pueden establecer un vínculo entre los Estados y la sociedad. Con sus acciones y su desempeño son capaces de llenar vacíos dejados por el Estado moderno en la representación de las aspiraciones de la sociedad. En razón a un marco teórico breve y específico, este artículo presenta una explicación sobre las ONG y su estatus en el derecho internacional, a fin de permitir una reflexión sobre su impacto en la conclusión de tratados internacionales, a través del análisis de la Convención sobre los Derechos del Niño, la Convención sobre Minas, Estatuto de Roma.
Justiça juvenil em pauta internacional: perspectivas à efetivação da normativa sobre direitos humanos das crianças e adolescentes privados de liberdade
Authors: Motta Costa Ana Paula , Eilberg Daniela Dora
Published: May 2023

A constituição dos direitos das crianças e dos adolescentes enfrentou grandes oscilações no panorama normativo internacional, uma vez que historicamente figuram como moeda de “barganha política”, principalmente quando se tratam de indivíduos envolvidos com a esfera penal. A internacionalização dos direitos humanos e a ótica humanizada do processo penal foram modificações importantes e necessárias para conquistar progressos legais e políticos na esfera da infância. Este artigo busca identificar não apenas a evolução de tais direitos como também o modo de tratamento das crianças e dos adolescentes envolvidos com os sistemas de responsabilidade penal juvenil. Para tanto, realiza-se uma pesquisa bibliográfica e a análise comparada de dados a respeito das leis dos países latino-americanos concernente à temática.
Obligatoriedad del control de convencionalidad a la luz del derecho de los tratados
Authors: Aguilar Cavallo Gonzalo
Published: May 2023

Este trabajo tiene por objeto analizar si existen normas internacionales en las que se fundamente la obligación de los Estados de proceder a efectuar un control de convencionalidad en su esfera interna. Nuestra hipótesis es que esta obligación internacional se fundamenta en los artículos 26 y 27 de la Convención deViena sobre el Derecho de losTratados de 1969. El artículo examina la doctrina pertinente y utiliza las reglas de interpretación que la propia Convención deViena proporciona.
El racismo. Recorridos conceptuales e históricos
Authors:   SURXE y CEIICH-UNAM, Gall Olivia , Iturriaga Eugenia ,   UADY, Morales Diego ,   UAM-I, Rodriguez Jimena ,   SURXE -UNAM
Published: May 2023

El racismo es un fenómeno que se ha presentado a lo largo del tiempo de muy diversas maneras. Sus manifestaciones han sido muchas y varían dependido de la época y el contexto en el que se presentan. Este libro contribuye a la comprensión del complejo fenómeno que es el racismo, recorriendo y analizando los conceptos que nos permiten identificarlo donde quiera que se presente. Conocer las historias pasadas y presentes de este fenómeno en el mundo, nos permitirá poder comparar y así entender mejor cuáles son las particularidades del racismo en el contexto mexicano. Sólo entendiendo las diferencias en los tiempos y los espacios donde tiene lugar, podremos encontrar las mejores formas de combatirlo.