bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Lyme borreliosis incidence during the COVID-19 epidemic
Authors:   I. Horbachevsky Ternopil National Medical University, Ukraine, Sverstyuk A.S. , Nykytyuk S.O. ,   I. Horbachevsky Ternopil National Medical University, Ukraine, Panуchev V.O. ,   SI «Ternopil Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine», Klymnyuk S.I. ,   I. Horbachevsky Ternopil National Medical University, Ukraine, Yakymchuk Y.B. ,   I. Horbachevsky Ternopil National Medical University, Ukraine
Published: December 2023

The global pandemic caused by the SARS-CoV-2 virus has created unprecedented health, social and economic challenges, and has led to a sharp decline in official statistical reporting of many infectious diseases, including Lyme borreliosis (LB), especially in children, due to COVID-19-related health, anti-epidemic and quarantine measures. Purpose - to assess the completeness of statistical accounting of LB in children against the background of the COVID-19 situation in the context of the epidemic in the Ternopil region of Ukraine that began in the spring of 2020. Materials and methods. A PubMed search was conducted for analytical articles on LB and COVID-19 for the period from 2020 to February 2023. Epidemiological analysis and forecasting were performed using statistical methods. The search included 300 publications. After the selection process, 25 publications were included in the review. The results of long-term epidemiologic surveillance of tick-borne infectious diseases in the Ternopil region, including data from official statistics, epidemiologic investigations, and laboratory studies, were analyzed. To predict the incidence of LB in the first half of 2023 for the age group 0-17 years, over 17 years and all age groups, increasing polynomial trends of the second order with approximation coefficients equal to 1 were used. To predict the incidence of COVID-19 in the first half of 2023 for the age group 0-17 years, an increasing linear trend with an approximation coefficient equal to 0.8 was used. To predict the incidence of COVID-19 in the first half of 2023 for the age groups 18-29 years, 30-49 years, 50-65 years, over 65 years and all age groups, we used decreasing polynomial trends of the second order with approximation coefficients equal to 1. The vast majority of the highest values of the approximation coefficients confirm the high accuracy of predicting the incidence of VL and COVID-19 in the first half of 2023 in the Ternopil region. Results and conclusions. The officially registered number of cases of pulmonary disease, including among children, during the COVID-19 epidemic in Ternopil region is likely incomplete and does not reflect the actual incidence rate. This is due to the problem of identifying patients with pulmonary disease during the COVID-19 epidemic. After a sharp decline in reported cases of LB in 2020 compared to previous years, in 2021-2023, there was an improvement in its detection and diagnosis, but at levels lower than before the COVID-19 epidemic. However, the proportion of children is decreasing. No conflict of interests was declared by the authors.
Peculiarities of the state of local immune in children with inflammatory auditory tube
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Havrilenko Y.V. , Melnikov A.F. ,   SI “Institute of otolaryngology named after professor O.S. Kolomiychenko of the NAMS of Ukraine”, Kyiv, Laiko A.A. ,   Shupyk National Healthcare University of Ukraine, Kyiv, Sinyachenko V.V. ,   Shupyk National Healthcare University of Ukraine, Kyiv, Biletska M.A. ,   Shupyk National Healthcare University, Kyiv, Ukraine
Published: December 2023

Purpose - to find the factors of local immunity in secret in the region of the pharyngeal opening of the auditory tube (SPOAT) in normal conditions and in the inflammatory process; а compare indicators of local immunity in SPOAT and oropharyngeal secretion (OPS). Materials and methods. In the ENT department of the National Children’s Specialized Hospital “OKHMATDYT” were examined 38 children from 2.5 to 15 years old, 27 of them with inflammation of the auditory tube (IAT) and 11 patients without inflammation of the auditory tube (control group). Radial immunodiffusion was used to detect the level of immunoglobulins (Ig) A, E, M, G, secretory and the IgA monomer in SPOAT and OPS. The level of cytokines and lactoferrin was determined by enzyme immunoassay using a Stat-Fax 2100 reader (USA). Results. It was found that in children with IAT, the concentration of secretory IgA in the SPOAT was lower, the level of lactoferrin was lower, the level of IgG was higher, and total IgE was three times lower than in children of the control group. The concentration of γ-interferon in SPOAT in children of the control group was 7 times higher than in children with IAT. It has been found that delayed hypersensitivity reactions in the development of IAT in children are not significant. The concentration of secretory leukocyte protease inhibitors (SLPI) in SPOAT in sick children was almost 10 times higher than in the control group. At the same time, in the OPS, the content of SLPI in healthy children was within 37.6 pg/ml, and in children with IAT, the average content of SLPI was 7.6 pg/ml. Conclusions. A comprehensive study of immune defense factors at the local and systemic levels in children with IAT was carried out. The protective role of IgE in healthy donors, the importance of lactoferrin and SLPI were revealed. The concentration of inflammatory factors (interleukin-1, 8, IgG, tumour necrosis factor α) can increase near the focus of inflammation, which indicates a high content of reaginic antibodies in the SPOAT of practically healthy children and can be determined as a protective element, which is a new immunodiagnostic test. Significant differences in the content of γ-interferon and SLPI were revealed. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Malabsorption syndrome after gastroenteritis in children, optimization of therapy
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Shadrin O.H. , Marushko R.V. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Marushko T.L. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Kovalchuk A.A. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Mostovenko R.V. ,   National Children’s Specialized Hospital «OKHMATDYT», Kyiv, Ukraine
Published: December 2023

The period of convalescence after gastroenteritis in children in modern circumstances is often complicated by the development of post-infectious malabsorption syndrome, in the pathogenesis of which the development of bacterial overgrowth syndrome (BOS) is important. At present, the issue of treatment of BOS in children has not been finally resolved. The use of modern enterosorbents can be considered a good alternative to antibacterial therapy of BOS. Purpose - to evaluate the effectiveness of the inclusion of highly dispersed silicon dioxide in the complex therapy of malabsorption syndrome after gastroenteritis in children. Materials and methods. 30 children aged from 3 to 12 years with malabsorption syndrome after gastroenteritis during the last 6 months were under observation. Patients on the background of standard treatment were prescribed highly dispersed silicon dioxide for 3-5 days. In dynamics, subjective complaints of patients and/or their parents were assessed, clinical symptoms and results of coprological and bacteriological examination of feces were evaluated. Results. While including highly dispersed silicon dioxide into the treatment, in the vast majority of patients (according to individual indicators, 75-85%), a rapid normalization of the frequency and consistency of stools, a decrease in the frequency and severity of flatulence, improvement of digestion and assimilation of nutrients according to the indicators of a coprological study, which had a positive effect on the general condition, were noted. The results of the bacteriological examination of feces in dynamics showed a significant decrease in the frequency of detection and the number of opportunistic bacteria, fungal flora and tendency to increase the number of representatives of the indigenous microflora. Conclusions. The results of the work make it possible to recommend the inclusion of enterosorption with the usage of highly dispersed silicon dioxide in the complex of restorative therapy in children with malabsorption syndrome after gastroenteritis. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution mentioned in the work. The informed consent of the children’s parents was obtained for the conducting the studies. No conflict of interests was declared by the authors.
Key principles and advanced approaches to quality assurance of phytopharmaceuticals
Authors: Zupanets К.О. , Ratushna K.L. ,   National University of Pharmacy, Kharkiv, Ukraine
Published: December 2023

Due to the specificity of the composition and production of herbal medicines, ensuring their quality is particularly important, but at the same time an extremely difficult task. Purpose - to review the key problems, principles and aspects of the quality of herbal medicines and generalize advanced approaches to ensure their quality using the example of a phytoneering drug for the treatment of cough in acute bronchitis and inflammatory diseases of the respiratory tract. The concept of the quality of the phytoneering drug was considered and analyzed. The central role belongs to the well-founded choice of starting plant material, the use of cultivated subspecies of plants and own seed material, which is of critical importance for ensuring the optimal and stable phytochemical composition of the extracts. In addition, the quality of the phytoneering medicines is determined by strict compliance with the GACP guideline, a standardized production process in accordance with GMP using the latest patented technologies, leading procedures for continuous quality control and the possibility of analyzing the multicomponent composition of the obtained extracts. Thus, the concept of phytoneering provides a thorough and comprehensive methodological basis for establishing quality at each stage of the life cycle of the drug and the reproducibile and consistent quality of extracts from batch to batch. Together with a thorough evidence base of preclinical and clinical research all this is an absolute competitive advantage of the phytoneering medicine over other herbal drugs. No conflict of interests was declared by the authors.
Relating BE and HAVE via transitivity: Evidence from Greek
Authors: Kampanarou Anna
Published: December 2023

This paper explores the syntax of HAVE, with a focus on Greek stative (existential and possessive) sentences, and argues against the need to postulate multiple BEs and HAVEs in this context, on the grounds that HAVE, in all its guises, behaves as a transitive verb, whereas BE behaves as an unaccusative. By adopting Myler’s (2016; 2018) proposal, which comprises an analysis based on suppletive allomorphy, I maintain that BE and HAVE are PF-exponents of the same semantically vacuous v-head, i.e., vBE, and the choice between them is determined by transitivity: HAVE realizes vBE when the structure is transitive, whereas BE does so when the structure is intransitive. By relating transitivity to Voice, as per Kratzer (1996), this translates into the assumption that HAVE appears when a transitive Voice head is projected in the structure, whereas BE is merged in the absence of this projection.
Comprehension of definite expressions by Mandarin-speaking children with suspected developmental language disorder (DLD) and children with autism spectrum disorder and language impairment (ALI)
Authors: Zhang Zhenghao , An Shasha , He Xiaowei
Published: December 2023

An increasing number of studies have shown that there is a subgroup inside children with autism spectrum disorder (ASD) who demonstrates impaired language profiles similar to children with developmental language disorder (DLD). As a discriminative marker, the determiner element is known to be particularly vulnerable in children with DLD, while less is known about the situation in children with ASD who show accompanying language impairment (ALI). The current study therefore investigates whether and how Mandarin-speaking children with DLD and children with ALI differ in their comprehension of definite expressions.To this end, 28 children with suspected DLD (Mean=5;2, SD=0;7), 32 children with ALI (Mean=5;3, SD=0;8), and 28 typically-developing children (Mean=5;3, SD=0;5) participated in the present study. Each child was experimentally tested on a series of picture judgment tasks, in which demonstrative-classifier NPs, third-person pronouns, and bare NPs were examined in the anaphoric environment.The findings showed that neither of the suspected DLD or ALI groups performed at target-like levels on the three definite expressions. This is most likely caused by the two groups’ immature knowledge of the syntax-semantics interface within the DP construction. Nonetheless, there remains a significant difference in the interpretation of third-person pronouns between the suspected DLD and ALI groups, with the worse performance in the latter group presumably resulting from co-morbid processing differences typical of individuals with ASD.
The Mexican Pas de Trois of Flann O’Brien, Graham Greene, and Shirley Temple: The Background to At Swim-Two-Birds’s Back Cover Blurb
Authors: Ó Méalóid Pádraig
Published: December 2023

Pádraig Ó Méalóid investigates the circumstances under which one of the leading novelists of the twentieth century, Graham Greene, came to write a blurb for the back cover of the first edition of Flann O’Brien’s debut novel At Swim-Two-Birds, published by Longmans, Green & Co. in 1939.
“PREFERENTIAL LEGAL RELATIONS” UNDER RUSSIAN CIVIL LAW
Authors:   Seventeenth Arbitration Court of Appeal, Golubtsov V. G. ,   Perm State University, Formakidov D. A. ,   Perm State University
Published: December 2023

Abstract: the article is devoted to the study of civil legal relations, which include various preferential rights in their content. Attempts to single out and isolate “preferential legal relations” within the framework of the legal regulation existing in our country are critically evaluated. The possibilities of attributing preferential rights to the group of real or obligatory subjective civil rights are analyzed. New approaches to the classification of preferential rights in civil law are proposed. It is concluded that there are currently no prerequisites for the allocation of “preferential legal relations”, as well as the allocation of legal relations that include preferential rights in their content into a separate type of civil legal relations.
THE REQUIREMENTS OF GOOD FAITH, REASONABLENESS AND FAIRNESS AS CIVIL LAW AXIOMS
Authors:   Perm State University, Komissarova E. G. ,   Tyumen State University, Kuznetsova O. A. ,   Perm State University,   Perm Institute of the Federal Penal Service of Russia
Published: December 2023

Abstract: the article is devoted to the analysis of the legal nature of the requirements of good faith, reasonableness and fairness provided for in paragraph 2 of article 6 of the Civil Code of the Russian Federation to overcome gaps in law. The necessity of considering these requirements from metatheoretical methodological positions that allow covering various aspects of their essence is established. The requirements of good faith, reasonableness and fairness manifest themselves in civil law as: spiritual and moral foundations, principles, presumptions, legal norms, legal obligations, the criterion for interpreting legal norms. The variety of semantic shades and functions of these requirements, as well as their close connection with morality, their elementary nature and obviousness, allow us to qualify them as civil law axioms.
RECOGNITION OF OBLIGATIONS OF SPOUSES AS COMMON IN BANKRUPTCY
Authors:   Perm State University, Kurkova N. A. , Strogonova T. P. ,   Perm State University
Published: December 2023

Abstract: the article is devoted to controversial issues of recognizing the obligations of the debtor and his spouse as common in cases of bankruptcy of a citizen. The article considers the functioning of such legal constructs of the branch of family law as property relations of spouses, as well as their liability for obligations to creditors in cases of bankruptcy of a citizen. The conclusion is made about legally significant circumstances that should be clarified when considering cases on recognizing obligations as common. Establishing the purpose of receiving the amount of money, as well as establishing whether the money was spent on the needs of the family are the main criterion with which such recognition is connected. Obligations arising from the guarantee agreement are not common, as they are of a personal nature.
ORGANIZATIONAL AND PROCEDURAL PROBLEMS OF ESTABLISHING THE SEVERITY OF HARM TO HEALTH
Authors:   Perm State University, Li O. Yu.
Published: December 2023

Abstract: the article outlines the grounds for the appointment and production of a forensic examination to establish the severity of harm to health in living persons, namely a forensic medical examination; gives the basic concepts; presents regulatory legal acts regulating the appointment and production of this type of expertise; considers organizational and procedural problems faced by law enforcement officers when raising questions for a forensic medical expert, ways to solve them, as well as some difficulties in drawing up a conclusion by a forensic medical expert.
PROBLEMS OF ENSURING THE CONSTITUTIONAL RIGHTS OF CITIZENS IN THE PROCESS OF SEIZURE OF ELECTRONIC INFORMATION IN CRIMINAL PROCEEDINGS
Authors:   Perm State University, Malygin K. V. ,   Perm Regional Court
Published: December 2023

Abstract: the article deals with the legal status of electronic messages transmitted via cellular communications and the Internet, as well as the procedure for access to them by law enforcement agencies established by the legislation of the Russian Federation. Analyzing the current law enforcement practice related to the seizure of electronic carriers during investigative actions, the author draws attention to the fact that the subsequent examination of correspondence in electronic carriers usually is carried out without the permission of the court. At the same time, the author comes to the conclusion that this practice does not always take into account the provisions of the legislation concerning the legal regime that ensures the right to secrecy of correspondence, telephone conversations, postal, telegraph and other messages.
THE IMPACT OF THE DIGITAL TRANSFORMATION OF SOCIETY ON OTHER PROCEDURAL ACTIONS AS METHODS OF EVIDENCE IN CRIMINAL PROCEEDINGS
Authors:   Perm State University, Bykov D. S. ,   Judical District No. 1  of the Bardymsky Judical District of the Perm Region
Published: December 2023

Abstract: in the article, for the purposes of studying the impact on other procedural actions as ways of proving in criminal proceedings, the concept of the digital transformation of society is given, the relevance of the topic of the article is highlighted. The author examines the impact of the digital transformation of society on the productivity of the preliminary investigation bodies and the increase in the effectiveness of proof, and provides examples of the use of other procedural actions in the practical activities of the preliminary investigation bodies in the context of the digital transformation of society, in particular such procedural actions as obtaining explanations, including by remote means, seizure objects and documents, reclamation of documents and objects and their voluntary presentation. In conclusion, it is concluded that the digital transformation of society in the future will lead to an increase in the productivity of preliminary investigation bodies, a reduction in the terms of criminal proceedings, saving material resources and labor costs.
TO THE 65TH ANNIVERSARY OF THE DEPARTMENT OF CRIMINAL PROCEEDINGS AND CRIMINALISTICS AT PERM STATE UNIVERSITY
Authors:   Perm State University, Borisevich G. Ya.
Published: December 2023

Abstract: the article describes the stages of development of the Department of Criminal Procedure and Criminalistics of the Law Faculty of Perm State University are shown and presents the most significant results of research, educational, methodological, social and educational activities.
LEGAL REGULATION OF INDIVIDUAL INVESTIGATIVE ACTIONS IN RELATION TO JUDGES
Authors:   Perm State University, Dobrovlyanina O. V.
Published: December 2023

Abstract: the article notes that investigative actions are carried out in a special manner with respect to judges. The types of individual investigative actions in relation to judge are investigated. The rules of the Criminal Procedure Code of the Russian Federation and the Federal Law “On the Status of Judges in the Russian Federation” on the procedure for conducting individual investigative actions in relation to judges deprived of immunity, as well as against judges not deprived of immunity, are considered. The provisions of the law on search in relation to these categories of judges are critically evaluated. The necessity of abandoning a special procedure for conducting a search in relation to judges is justified. The conclusion is made about the expediency of simplifying criminal proceedings in relation to judges. Arguments are presented about the need to exclude the inconsistency of the norms of various laws on the procedure for conducting individual investigative actions in relation to judges.
Impact of Two Grazing Strategies on Rangeland Basal Cover and Beef Production in the Sourish Mixed Bushveld
Authors: Grobler S.M. , Van der Westhuizen H.C. , Snyman H.A. , Scholtz M.M. , Neser F.W.C. , Greyling J.P.C , Morey L. , Trytsman M.
Published: December 2023

The sustainability of beef cattle producers in South Africa is greatly dependent on the availability of natural resources. The aim of the study was first to evaluate the effect of two different strategies in the utilisation of rangeland over four years (2011/12 – 2014/15) on the basal cover—secondly, the study compared animal production results from the two extensively managed rotational grazing strategies. Grazing strategies include a traditional rotational system (TRG), where approximately 60% of fodder was utilised, compared with light selective grazing (LSG), where about 30% of fodder was used. Basal cover for TRG ranged from 19% (2011/12) to 15% (2014/15) and for LSG from 18% (2011/12) to 16% (2014/15). The calving percentage varied between 62% and 73%. The calving percentage and cow and calf weight did not differ between the two grazing strategies, although differences between years were observed. Both grazing systems can be implemented successfully in the Sourish Mixed Bushveld without negatively affecting the rangeland. However, basal cover may be more vulnerable during drought conditions under a TRG system. The study further indicates that mainly small-scale farmers, where utilisation levels of rangelands are usually high, are more vulnerable to drought conditions.
The influence of dark chocolate consumption on the microbial population in the oral cavity
Authors: Mișcă Corina , Raba Diana , Dumbravă Delia , Moldovan Camelia , Borozan Aurica Breica , Popa Mirela , Rinovetz Alexandru , David Ioan
Published: December 2023

This study was initiated at the Faculty of Food Engineering within the Mihai I University of Life Sciences in Timișoara, with the aim of identifying the effect of dark chocolate with a high concentration of cocoa on the microbial population in the oral cavity, which facilitates the formation of dental plaque, tartar and implicitly the appearance of dental caries. The specialized literature directed us to this study and we wanted to highlight the presence of microorganisms that can be isolated from the oral cavity and the effectiveness of this treatment - the consumption of dark chocolate after meals, in small quantities. The methods for isolating microorganisms were the classic ones imposed by the standards. The results obtained confirmed the bactericidal effect of dark chocolate with a high cocoa content. In conclusion, the consumption of a quantity of 10 grams of dark chocolate, after the meal exerted a beneficial effect on oral hygiene, by reducing the number of acidogenic microorganisms.
Protocol for fixing and peeling Aedes aegypti embryos v1
Authors: Reid William
Published: December 2023

The collection, fixing, and immunohistochemical staining of Aedes aegypti embryos is challenging in comparison to D. melanogaster since the vitelline membrane of Ae. aegypti must be manually removed. Herein we report on an improvement for the methods to prepare Ae. aegypti embryos. The adapted protocol increases the throughput capacity of embryos by an individual user, with experienced users able to process an average of 100-150 embryos per hour. The protocol provides high-quality intact embryos that can be used for morphological, immunohistochemical, and in situ RNA hybridization studies. Critical to the success of the optimized protocol is the selection and description of the tools required, and differing approaches for younger and older embryos.
Automated Immunohistochemistry Staining v1
Authors: J Curless Toby , Ramesh Nelvagal Hemanth , Jaunmuktane Zane
Published: December 2023

The protocols describes the steps for automated immunohistochemistry staining using the Ventana Discovery® XTImmunostainer.
Single-cell Whole Genome Amplification (scWGA) of human frozen post-mortem brain samples isolated by Laser Capture Microdissection (LCM) v1
Authors: Kalef-Ezra Ester
Published: December 2023

This protocol uses Laser Capture Microdissection (LCM) technology on human post-mortem brain tissue slides with rapid Giemsa staining to isolate single nuclei for Single-cell Whole Genome Amplification (scWGA) in order to do low coverage (<1x) single-cell whole genome sequencing to detect mega-base somatic Copy Number Variations (CNVs).
General Microtome Sectioning of Formalin-Fixed Paraffin Embedded (FFPE) blocks v1
Authors: J Curless Toby , Jaunmuktane Zane
Published: December 2023

This protocol describes the steps for the sectioning of formalin-fixed paraffin embedded blocks in preparation for further tissue processing such as immunohistochemistry.
CD3 Cell Density in Substantia Nigra and Cerebral Peduncle Image Analysis v1
Authors: Ramesh Nelvagal Hemanth , J Curless Toby , Jaunmuktane Zane
Published: December 2023

QuPath is a bioimage analysis software designed for digital pathology and whole slide image analysis. This protocol describes how to measure CD3 density in the substantia nigra and cerebral peduncle using haematoxylin and DAB-stained brain sections.
RNA/DNA extraction from plankton natural samples using NucleoSpin RNA + RNA/DNA Buffer kits (Macherey Nagel) v2
Authors: Romac Sarah , Ratin Morgane
Published: December 2023

This protocol has been developped for simultaneous nucleic acid (RNA and DNA) extraction from environmental water samples collected by filtration on polycarbonate 47mm and 142mm filters. It has been developped during BioMarks project (2009-2013) and has been used in many projects studying plankton diversity (TARA-OCEANS 2009-2013, TARA-PACIFIC 2016-2018, TONGA 2019), and plankton monitoring projects (MOOSE-GE 2017- ongoing). This protocol is applied in routine in our lab and also in CEA Genoscope.
Surgery free rat closed head repetitive mild injury model of traumatic brain injury v1
Authors: not provided vedad.delic
Published: December 2023

This is a surgery-free closed head weight drop injury protocol for repetitive mild TBI of adult rats. The model consists, of a guide tube and weight cylinders that deliver an injury to the calvarium of an anesthetized rat in prone position on a sponge causing rotational acceleration. Rats typically recover without incident with the most common adverse occurrence being a nose bleed. 4 injuries 2 weeks apart with 1.5 kg weight did not result in detectable pathology, but 8 injuries resulted in regional astrogliosis, microgliosis, encephalomalacia, without overt motor deficits.
Implementation of Pancasila Values in Character Education: A Literature Review
Authors: Natalia Veronica Eka Desi , Pratama Anisa OS , Astuti Margareta Dewi
Published: December 2023

The implementation of Pancasila values in character education is very important and interesting to discuss. There are a number of articles related to the implementation of Pancasila values in character education but there is still little literature on the literature review. The purpose of writing this article is to identify and identify the implementation of Pancasila values in strengthening character education as a literature review. Based on the literature review, it is known that the implementation of Pancasila values is very important in relation to character education. Characters that are appropriate and are shown attitudes related to the values contained in Pancasila, namely the values of character divine values (religious), love for the country, independence, environmental care and tolerance .
The Effectiveness of The Sufistic Core Character Learning Model in Increasing Student Religiosity and Character
Authors: H.M. Yahya M. Wildan Bin , Rahmat Munawar
Published: December 2023

The Qur'an-based Sufistic approach in religious education in Islamic boarding schools has proven to increase the students' holy obedience and noble character. But in college, this approach is never used. Religious education increases students ' religiosity and noble character with a conventional lecture approach (not a Sufistic approach). This study aims to test the effectiveness of the 'Sufistic Core Character' learning model to increase students' religiosity and morals. The research method used is quasi-experimental. The three experimental classes used the 'Sufistic Core Character' learning model, while the other three (control class) used the conventional learning model. The lecture material for both courses is the same, namely about religiosity and morality. Before the lecture, both types were tested (pre-test), and after eight lessons, they were tested again with the same test (post-test). As a result, there was an increase in scores in both classes studied. But the increase in scores in the experimental category was higher than in the control class. Thus, the 'Sufistic Core Character' learning model increases students' religiosity and noble character more effectively than conventional learning models.
Use of daratumumab drug formulation for subcutaneous administration in multiple myeloma therapy: Literature review and clinical observation
Authors: Zeynalova P. A. , Timofeeva O. L. , Ryabukhina Yu. E. , Abbasbeyli F. M. , Kupryshina N. A. , Zhukov A. G. , Valiev T. T.
Published: December 2023

Study of the molecular pathogenesis of multiple myeloma led to development and introduction of antitumor agents with new mechanisms of action and their combinations into clinical practice. According to several trials, use of anti-CD38 monoclonal antibody daratumumab as part of triplet therapies at an early stage leads to deep and long-term antitumor response, achievement of MRD-negative status, and, as a result, increased survival and improved prognosis in all patient subgroups. High effectiveness of daratumumab subcutaneous formulation close to intravenous formulation has favorable safety profile, short administration time and low rate of infusion reactions which improves patients’ quality of life, affects their treatment compliance, and decreases healthcare costs.

We present a clinical observation of a 60-year-old patient with newly diagnosed multiple myeloma who previously underwent treatment for another lymphoproliferative disorder which included autologous hematopoietic stem cell transplantation leading to complete and long-term remission. After 9 intravenous daratumumab infusions (with recommended dose of 16 mg/kg) in accordance to the D-Rd regimen, evaluation of antitumor effect and consideration of socially active lifestyle of the patient, daratumumab formulation for intravenous administration was replaced with subcutaneous formulation of fixed dose 1800 mg. Further deepening of the antitumor response was observed along with manageable safety profile and absence of significant adverse events which allowed to maintain intercourse intervals and improve the patient’s quality of life.
Soil cultivating with a tiller with V-shaped knives
Authors: Tarasenko Boris F. , Niyomuvunyi Angelos , Drobot Viktor A. , Rudnev Sergey G. , Blinova Anastasia I.
Published: December 2023

BACKGROUND: The necessity in intensification of agriculture with growing crop products needs demands constant improvement of soil-cultivating working bodies. Increase of field yield rate requires measures of their recultivation and melioration. Moreover, the demand in restoring crop acreage retired from crop rotation due to human economic activities.
AIMS: Justification of energy consumption of soil cultivating process with a tiller with V-shaped knives.
METHODS: Accomplishment of the given research tasks and calculation of the power demanded for operation of the proposed rotational mechanism with V-shaped knives, are done with resolution into components: power for overcoming of constant resistance, power for tillage process (deformation of soil shavings) and power of soil throwing-away. Processing of the theoretical data was performed with the Microsoft Office software package.
RESULTS: With the analysis of theoretical curves of influence of notion velocity and number of knives in plane of the proposed working body, it is apparent that having three knives in plane of the working body the resistance per knife almost doubles that leads to overall increase of soil resistance to the whole working body. Meanwhile, increase of motion velocity has a positive effect on lowering the reaction of soil on the working body.
CONCLUSIONS: With the analysis of the given data, it is observed that values of soil resistance change the tendency to the positive one with velocity increasing.
Simulation model of a vehicle in the Simulink environment for determining fuel consumption in driving cycles
Authors: Khimchenko Arkady V. , Mishchenko Nikolay I. , Bykov Valery V.
Published: December 2023

BACKGROUND: The paper shows that the problem of determining objective indicators of fuel consumption in operation based on calculation methods remains relevant. One of these methods is simulation modeling. Current state of computer technology significantly simplifies building of system simulation models, for example, using the Simulink software by Mathworks. In the process of model development, it is necessary to keep the balance of generalization and detailing, since excessive detailing leads to an unreasonably deep consideration of individual elements of the system and to a significant increase in simulation time.
AIMS: Search for a reasonable structure of model of the driver car environment system, which makes it possible to simulate the car in driving cycles or other driving scenarios.
METHODS: The MATLAB/Simulink simulation environment was used in the study. Based on the analysis of the car design and the capabilities of individual Simulink tools, a block diagram to study fuel consumption using the example of a passenger vehicle was synthesized. The obtained model was debugged for the stable motion simulation of the vehicle in various driving cycles using graphical analysis.
RESULTS: The obtained results show that the developed system simulation model is well behaved. Control systems ensure the vehicle motion according to the mixed driving cycle modes in compliance with the required tolerances. It is possible to register fuel consumption and other simulation results of interest.
CONCLUSIONS: The model showed the relative simplicity of setting up and the ability of quick update for other vehicles. A minimal amount of vehicle data is required to bring the model to an operable condition. Particular unknown parameters are supposed to be refined using identification methods.
The Tractors and Agricultural Machinery journal increases the level of publications
Authors: Arseniev Sergey Y.
Published: December 2023

Based on the results of re-registration and based on the results of 2022, the Higher Attestation Commission of the Ministry of Education and Science of Russia included the journal Tractors and Agricultural Machinery in the list of peer-reviewed scientific publications in which the main scientific results of dissertations for the scientific degree of Candidate of Sciences, for the scientific degree of Doctor of Science should be published (information message ref. No. 02-1198 dated 12/06/2022).
And according to the coefficient of scientific significance, our journal is classified in category K1 (that is, in the top 25% of the total list of 2587 peer-reviewed scientific publications).
Tractors and Agricultural Machinery simultaneously expanded the list of scientific specialties in the branches of science in which academic degrees are awarded: six new specialties were added to the previous four.
The Interdisciplinary Diagnostics of Autism Spectrum Disorder Using DC:0-5TM: A Case Report
Authors: Skoblo Galina V. , Trushkina Svetlana V.
Published: December 2023

BACKGROUND: The Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood (DC:0-5TM) is widely used in many Western countries. For Russian specialists, such classification represents a relatively new tool for the comprehensive diagnosis of mental disorders in children from birth to the five-year-old threshold. The purpose for presenting this case study report is to showcase the practical application of the DC:0-5TM.
AIM: This study aims to illustrate the diagnostic process according to the DC:0-5TM criteria using the example of a specific clinical case report involving the collaborative efforts of two specialists: a child psychiatrist and a clinical child psychologist.
METHODS: DC:0-5TM consists of five axes. The main axis focuses on clinical diagnosis criteria for mental disorders, considering their age specificity. The remaining four axes allow one to take into account and specify data related to biological, social, and psychological factors, which play a crucial role in understanding the causes and characteristics of a mental disorder in a child.
RESULTS: In the examined case, an analysis of symptoms by means of the Clinical Disorders axis revealed that they were consistent with the diagnostic criteria for autism spectrum disorder. The use of the remaining axes supplemented the clinical diagnosis with specific details about the adverse physical health factors in the child, a high cumulative stress burden, significant developmental delays in the emotional, speech, and social dimensions, as well as dysfunction in the mother-child dyad. Since the parents declined medication for their son, this information proved crucial in developing a support program for both the child and the family.
CONCLUSION: The comprehensive diagnostic approach using the DC:0-5TM axes proved highly effective, not only in psychiatric diagnosis but also in establishing goals and objectives for subsequent intervention. Its application in psychiatric, clinical psychology, and corrective educational practices has the potential to make support for children in their early years a more personalized and family-oriented undertaking.
Age of Arrest and Future Offending
Authors:   , DeYoung Lena , Goldstein Naomi E
Published: December 2023

Age at first arrest is an often-cited predictor of future offending behavior. Given recent criminalization of normative adolescent school behavior and the increased presence of police and other law enforcement personnel in schools, youth may now experience their first arrest at school and at a younger age-raising questions about whether the established relationship between age at arrest and future offending exists for youth first arrested in schools. Therefore, this study examined data from 671 students first arrested in Philadelphia schools in the 2013-2014 academic year to determine whether younger age at first arrest was related to higher likelihood of rearrest and/or a greater number of rearrests over a 5-year period, while controlling for gender, race, and offense type. I conducted binary logistic and Poisson regression analyses to investigate these relationships. Consistent with hypotheses, youth first arrested at younger ages were more likely to be subsequently arrested and were arrested more often within a 5-year follow-up period. Observed results reiterate age at first arrest as a potential risk factor for future legal system involvement-including when such arrests occur at school-and underscore the potential benefit of responding to youth misbehavior with rehabilitative interventions rather than punitive ones- thus minimizing harmful and prolonged contact with the legal system and potentially reducing detrimental labeling effects that can perpetuate misbehavior.
Reproducible and Efficient Deep Reinforcement Learning
Authors:   , Huang Shengyi , Ontañón Santiago
Published: December 2023

Deep reinforcement learning (DRL), a paradigm by which agents learn how to do tasks through trial and error, has achieved great success in many domains. Researchers have successfully applied DRL to train autonomous agents that learn to play video games from pixels and control simulated robots, all the way up to design microchips. Despite these impressive accomplishments, DRL algorithms can be hard to reproduce due to their sensitivity to hyperparameters and seemingly unimportant implementation details. Additionally, running DRL algorithms can be computationally inecient, especially in challenging domains such as real-time strategy (RTS) games which pose a significant challenge to DRL due to their large action space, sparse rewards, and partial observability. This thesis makes contributions toward making DRL more reproducible and ecient. First, we study how implementation details of DRL, often left out of academic publications, have a significant impact on algorithm behavior. We then propose a new framework to mitigate reproducibility issues, and this framework is encapsulated in a DRL library called CleanRL. We further identify and address reproducibility issues in distributed DRL with a new platform called Cleanba. Second, we build Gym-[mu]RTS, an efficient RTS testbed for conducting DRL novel research topics, such as game presentation designs and efficient learning techniques for dealing with invalid actions and sparse rewards. We also propose methods to scale agents to perform unit-level control in RTS games, lifting the artificial action space restriction of past works.
Geometric modification and placement of high heat flux ic chips on substrates of different materials for enhanced heat transfer
Authors: DURGAM Shankar , BHOSALE Ajinkya , BHOSALE Vivek
Published: December 2023

This article presents the significance of using different sizes and positions of IC (Integrated Circuit) chips that are mounted on substrates of different materials. The ICs are cooled by forced convection in a horizontal wind tunnel. COMSOL Multiphysics 5.4 solve the IC chip cooling problem by selecting a conjugate heat transfer module with laminar flow. FR4, ba-kelite, single and multi-layer copper clad boards are used as substrate materials. Numerical simulations are performed for FR4, bakelite with a constant heat flux of 5000 W/m2, at 2.5 m/s air velocity. In contrast, single and multi-layer copper clad boards are studied for 10000 W/m2 with 1.5 m/s air velocity. The prime objective of this research is to use adequate size and placement of chips generating high heat fluxes for enhanced heat transfer. Results showed that larger chips placed at bottom rows and sequentially decreasing sizes in the subsequent rows for the same overall input for high substrate thermal conductivity give more heat dissipation. Among all configurations A0 – F considered in the study, case E provides minimum tempera-ture using single and multi-layer copper clad boards. In addition to modification of chip sizes, geometric spacing of X1/X2 = 1.8 results in lower maximum temperature.
ANALYSIS OF THE EDUCATIONAL POSSIBILITIES OF THE THEME OF BLACK WOMEN IN MATHEMATICS
Authors: Silva Livia Jeniffer Faria da , Teixeira Ricardo Roberto Plaza
Published: December 2023

This article examines the experience of carrying out an educational presentation of scientific dissemination on the participation of black women throughout the history of mathematics, for high school students who visited the Campus of Caraguatatuba of the Federal Institute of São Paulo (IFSP), in May 29, 2023. Therefore, this work articulates research, teaching and extension, in an interdisciplinary way, with the aim of examining the pedagogical possibilities of the thematic axis of black women in mathematics. To support the investigation, a theoretical review was carried out on this subject, through the search for academic works on the subject, using, for this, the “Google Scholar” tool. A questionnaire, which was designed to ascertain the views of those present on the topics covered, was answered by 15 high school students who attended the presentation. The results of this research point to the importance of the concept of intersectionality that takes into account gender, race and class identities when investigating the trajectories of black women who are professionally dedicated to mathematics, as researchers and educators.
THE ROLE OF ART IN THE DEVELOPMENT OF THE CREATIVE PERSONALITY OF THE FUTURE TEACHER
Authors: Moroz Maiia , Lotsman Ruslana , Hudovsek Oksana , Pashchenko Inna
Published: December 2023

The article is devoted to the consideration of art in the system of development of the creative individuality of the future teacher. The relevance of the topic is due to the fact that when studying in the pedagogical direction, a student must acquire comprehensive knowledge, but not only profile knowledge, as a result of the introduction of art into the educational process will allow solving complex issues of the formation of the future teacher's personality. At the same time, having creative abilities, the teacher will be able to use them effectively in his work and spread interest in art and creativity among his pupils. The purpose of the research is to characterize art in the system of developing the creative individuality of the future teacher. The object of research is the pedagogical system of Ukraine. Such research methods as description, analysis and synthesis, comparison, generalization, and modelling were used in the scientific work. The article examines the peculiarities of art in the system of development of the creative individuality of the future teacher. The place of art in the aspect of the development of creative individuality is defined. Obstacles on the way to the introduction of art into the system of development of the creative individuality of the future teacher are characterized. The positive aspects of the introduction into the system of development of creative individuality of art have been identified. Such principles of the introduction of art in the training of the future teacher, which contribute to the development of creative individuality, as the introduction of a complex of education, science, and art, have revealed; a combination of cultural, creative, systemic approaches; individualization of the creative personality; sociocultural identification; ethnocultural affiliation. A model of the introduction of art in the system of development of the creative individuality of the future teacher has been developed. The place of art in the development of the creative personality of the future teacher has been determined.