bluuebunny/crossref_metadata_2025 huggingface dataset:
The MEK Inhibitor Trametinib Ameliorates Kidney Fibrosis by Suppressing ERK1/2 and mTORC1 Signaling
Authors: Andrikopoulos Petros , Kieswich Julius , Pacheco Sabrina , Nadarajah Luxme , Harwood Steven Michael , O'Riordan Caroline E. , Thiemermann Christoph , Yaqoob Muhammad M.
Published: December 2018

Background

During kidney fibrosis, a hallmark and promoter of CKD (regardless of the underlying renal disorder leading to CKD), the extracellular-regulated kinase 1/2 (ERK1/2) pathway, is activated and has been implicated in the detrimental differentiation and expansion of kidney fibroblasts. An ERK1/2 pathway inhibitor, trametinib, is currently used in the treatment of melanoma, but its efficacy in the setting of CKD and renal fibrosis has not been explored.

Methods

We investigated whether trametinib has antifibrotic effects in two mouse models of renal fibrosis—mice subjected to unilateral ureteral obstruction (UUO) or fed an adenine-rich diet—as well as in cultured primary human fibroblasts. We also used immunoblot analysis, immunohistochemical staining, and other tools to study underlying molecular mechanisms for antifibrotic effects.

Results

Trametinib significantly attenuated collagen deposition and myofibroblast differentiation and expansion in UUO and adenine-fed mice. We also discovered that in injured kidneys, inhibition of the ERK1/2 pathway by trametinib ameliorated mammalian target of rapamycin complex 1 (mTORC1) activation, another key profibrotic signaling pathway. Trametinib also inhibited the ERK1/2 pathway in cultured primary human renal fibroblasts stimulated by application of TGF-β1, the major profibrotic cytokine, thereby suppressing downstream mTORC1 pathway activation. Additionally, trametinib reduced the expression of myofibroblast marker α-smooth muscle actin and the proliferation of renal fibroblasts, corroborating our in vivo data. Crucially, trametinib also significantly ameliorated renal fibrosis progression when administered to animals subsequent to myofibroblast activation.

Conclusions

Further study of trametinib as a potential candidate for the treatment of chronic renal fibrotic diseases of diverse etiologies is warranted.
ALGORITHM OF PRACTICAL DEVELOPMENT OF THE INTERACTIVE THEMATIC MAP CRITICAL INFRASTRUCTURE OF KYIV CITY
Authors: Bondarenko E. , Shorokhova R. , Kyryliuk M.
Published: December 2018

The article is devoted to the consideration of issues of development of the multifunctional interactive thematic map of the critical infrastructure of Kyiv city with the wording of the corresponding algorithm. Based on the analysis of existing technological solutions for the practical development of interactive maps – electronic mapping models with the two-way user dialogical interaction and technical support of their functioning – for the specific solution substantiated application geoinformation technological approach with visualization.

The theoretical and methodological level of development of an algorithm for creating the interactive map of the critical infrastructure of Kyiv city with presentation on it of the conceptual model of the geographic data of the cartographical object, which includes: description and definition of geographical elements, which form it; select types of spatial objects to display critical infrastructure elements on the map; formulation of the solution of the question of how to represent their dimensionality and interrelationships with objects in reality; database contents; requirements for the obtained results. Methodological level of the algorithm for creating the interactive map of critical infrastructure according to the chosen technology provides for the development of the logical structure of the database elements in accordance with the management system of them, used in software, and also related with hardware and software tools for its physical realization.

The main stages of the algorithm for creating an interactive map of critical infrastructure of Kyiv city, which form the sequence of its creation, is defined: selection of software products to provide cartographic visualization of the necessary thematic information in the form of mapping indicators (critical infrastructure objects) geographically based on the application of the principle of multi-level generalization by tile technology solution and server approach (first stage); representation of data in the relational database in accordance with the definition and content of spatial objects and their transformation into mapping indicators (second); the formation of a web page for displaying general geographic and thematic information in the dialogue session of the user with an interactive mapping model (third stage).
ROMISING AVENUES OF USING AUGMENTED REALITY IN CARTOGRAPHY
Authors: Titova S. , Siryi B.
Published: December 2018

Augmented reality (AR) is the integration of digital information with the user’s environment in real time. AR software use in many different ways and for the needs of cartography too. This technology may be useful for the development of navigational mobile applications and actions with static (paper) maps.

There are two main operating modalities for implementation of augmented reality in applications: by markers and by the positioning of customer and surrounding objects (by azimuths determination between customer’s device and real objects). The first way is applied for static maps when another way is applied for navigational mobile applications.

Augmented reality provides at least six opportunities, which create better options for working with design and content of maps for cartographers. This technology also provides the new experience in the work on maps for customers.

The advantages of using augmented reality in cartography are the partial equation of static maps to geographical information systems, adaptability of cartographic images to the needs of users, improving the quality of design and content possibilities of maps and making actions with maps more attractive for customers. However, this technology is not without disadvantages, which connected with the development of AR-applications and requirements to smartphones.

In addition, this article reveals aspects of the creation of augmented maps in cartographic companies.
PRIORITY ASPECTS OF UKRAINIAN-POLISH COOPERATION IN GEOGRAPHY AND TOURISM IN MODERN CONDITIONS
Authors: Smyrnov I.
Published: December 2018

The article deals with new directions of Ukrainian-Polish cooperation in the field of tourism, on an example of the reconstruction of a high mountains observatory in the Carpathians and the use of tourist resources of towns – Ukrainian Kamyanets and Polish Tarniv. The Astronomical-Meteorological Observatory was built in the Eastern Carpathians on Mount Pip-Ivan (height 2028 m) in 1938 when the Carpathian region was part of Poland. Another name of the observatory is “White Elephant”, because in the winter under the snow the observatory house resembles the shape of the elephant. Mount Pip-Ivan has a pyramidal shape with the presence of ancient forms of glacial relief, made of sandstone. The observatory was equipped with the most up-to-date scientific equipment, in particular, a telescope, astrograph and refractor of British production. The Observatory was destroyed during the Second World War. Currently, with the joint efforts of Ukraine and Poland, in particular with the participation of the University of Warsaw and the Precarpathian University named after V. Stefanyk in Ivano-Frankivsk the restoration of the observatory is underway, as well as the construction of an International Center for Polish and Ukrainian Students Youth Meetings focusing on research in geography, meteorology, geology, seismology, astronomy and biology. Resource base and tourism development of Ukrainian Kamyanets and Polish Tarniv, which receives annually 4 times more tourists (more than 1 million), are characterized in comparison. Proposals are made for more effective use of the tourist potential of Kamyanets and increase of the number of Ukrainian and foreign tourists there.
Inclusive practices: the role of the support teacher
Authors: Soldevila Pérez Jesús , Naranjo Llanos Mila , Muntaner Guasp Joan Jordi
Published: December 2018

ABSTRACTThe purpose of this study is to describe and analyse the functions, tasks and actions of support teachers in inclusive classrooms in an ordinary school, moving from a therapeutic, integrative model to an inclusive one. Qualitative research in a longitudinal case study is presented, following two children with functional diversity over four years along three axes: the concept of inclusive education, the determination of good practices for inclusion and the role of the support teacher. The results allow us to propose different inclusive practices for support teachers, and a significant increase in the presence, participation and progress of these children in ordinary classrooms. We conclude that a conceptual change in the teaching approach of teachers can lead to the implementation of alternative teaching methods, requiring involvement of support teachers for adequate inclusion, through greater presence and participation in the ordinary educational activities of students with functional diversity, favouring their social, emotional and academic development and learning.Keywords: inclusive education, good inclusive practice, support teacher, special education teacher, educational change.RESUMENEl propósito de este estudio es describir y analizar las funciones, tareas y actuaciones del profesorado de apoyo en las prácticas inclusivas de aula en un centro ordinario que pasa de un modelo terapéutico e integrador a un modelo inclusivo. Para ello, se plantea una investigación cualitativa de estudio de casos longitudinal, con el seguimiento de dos niños con diversidad funcional durante cuatro años, fundamentada en tres ejes: el concepto de educación inclusiva, la determinación de buenas prácticas para la inclusión y el rol del profesor de apoyo. Los resultados han permitido definir diferentes prácticas inclusivas relacionadas con el profesor de apoyo, que han permitido un incremento significativo de la presencia, participación y progreso de estos niños en el aula ordinaria. Este trabajo nos permite concluir que un cambio conceptual en el modelo educativo de los docentes provoca la implementación de métodos didácticos alternativos, que exigen unas funciones del profesor de apoyo acordes con los planteamientos de la inclusión, que repercuten en una mayor presencia y participación de las actividades educativas ordinarias de los alumnos con diversidad funcional, favoreciendo su desarrollo y aprendizaje tanto social, emocional como académico.Palabras Clave: educación inclusiva, buenas prácticas inclusivas, docente de apoyo, maestro educación especial, cambio educativo.
Ser dos en el aula: las parejas pedagógicas como estrategia de co-enseñanza inclusiva en una experiencia de formación inicial del profesorado de secundaria
Authors: Cotrina García Manuel , García García Mayka , Caparrós Martín Ester
Published: December 2018

RESUMENEste trabajo aborda la “pareja pedagógica” como estrategia didáctica innovadora de corte inclusivo, que caracteriza una modalidad de enseñanza colaborativa (co-enseñanza). Esta estrategia requiere la implicación, intencional y voluntaria de dos profesores en todos los aspectos vinculados a la docencia: planificación, evaluación y, singularmente, durante el desarrollo de las sesiones de clases. Inicialmente se revisa la literatura sobre el tema de estudio, de cara a documentar su potencial en la mejora del proceso didáctico, e ilustrar sus implicaciones para el desarrollo profesional docente; asimismo, se centra el eje de análisis en la educación inclusiva. En un segundo momento, se presentan los resultados de un proyecto de innovación docente cuyo eje central es la puesta en acción de esta estrategia por un grupo de docentes de la Universidad de Cádiz, en diversas titulaciones vinculadas a la formación inicial del profesorado. En concreto, se presenta la visión particular del alumnado de la asignatura “Procesos y Contextos Educativos”, del Máster en Formación del Profesorado de Secundaria. Es a través de la voz del alumnado que el modelo de co-enseñanza, llevado a cabo en esta experiencia con las “parejas pedagógicas”, adquiere valor pedagógico y se sitúa como motor para la proyección hacia su práctica futura.Palabras Clave: co-enseñanza, pareja pedagógica, educación inclusiva, formación inicial del profesorado.ABSTRACTThis work approaches the “pedagogical partnerns” as an innovative didactic strategy of inclusive orientation, which characterizes a modality of collaborative teaching (co-teaching). This strategy requires the intentional and voluntary involvement of two teachers in all aspects related to teaching: planning, assessment and, in particular, during the development of class sessions. Initially the literatura on the subject of study is reviewed, in order to documents its potential in improving the didactic process, and to illustrate its implications for teacher professional development; likewise, the analysis focuses on inclusive education. Secondly, we presents the results of a teaching innovation project whose central axis is the implementation of this strategy by a group of teachers of the University of Cadiz, in various degrees related to the preservice teachers. Specifically, we present the students’ particular view on the subject “Processes and Educational Contexts” of the Master in Secondary Teacher Training. It is through the voice of the students that the co-teaching model, carried out in this experience with the “pedagogical partners” , get its pedagogical value and is placed as a motor so that the students can project it towards its future practice.Keywords: co-teaching, pedagogical pair, inclusive education, initial teacher training.
La educación emocional en la infancia: una estrategia inclusiva
Authors: Cepa Serrano Amaya , Heras Sevilla Davinia , Fernández-Hawrylak María
Published: December 2018

RESUMENEsta investigación está enmarcada dentro del ámbito de la Educación Emocional en edades tempranas. El objetivo de este estudio es comprobar la eficacia del Programa EMO-ACCIÓN de educación emocional, valorando su impacto en niños de 4 a 5 años con necesidades específicas de apoyo educativo. Para este trabajo se ha seleccionado un grupo de 22 alumnos/as de Educación Infantil con estas necesidades, de una muestra de 123 alumnos/as matriculados en un colegio ordinario preferente en limitaciones físicas. Se utiliza un diseño de medidas repetidas pre-test/post-test con grupos experimental (12 alumnos) y control (10 alumnos). Para ello, se administra antes y después de la intervención educativa la escala RRER para la medición de competencias emocionales. Los resultados muestran que los alumnos que participaron en el programa educativo incrementan de forma significativa sus competencias emocionales, encontrándose una clara mejora en las cinco dimensiones que se evalúan en la escala. El programa favorece el desarrollo de las competencias emocionales, tanto para alumnado que presenta o no dificultades educativas.Palabras Clave: competencias emocionales, educación infantil, alumnado con necesidades específicas de apoyo educativo, educación inclusiva, educación emocional.ABSTRACTThis research is framed within the emotional education at early childhood. The aim of this study is to test the efficiency of the EMO-ACCIÓN Program of emotional education, assessing its impact in 4-5 years old children with special educational needs. We selected 22 children within a sample of 123 schooled in a preferred ordinary center in physical limitations. A repeated measures design pretest/posttest was used, with experimental (12 children) and control (10 children) groups. In order to measure the emotional competences, the Recognition, Regulation, Empathy and Problem Solving Scale (RRER) was administered before and after the educational intervention. The outcomes show that the children who participated in the educational program increase their emotional competences significantly, with a clear improvement in the five dimensions that the scale evaluate. The program stimulates the development of emotional competences, both in the children with or without educational needs.Keywords: emotional competences, child education, students with special, educational needs, inclusive education, emotional education.
Motivación y realidad aumentada: Alumnos como consumidores y productores de objetos de aprendizaje. Motivation and augmented reality: Students as consumers and producers of learning objects
Authors: Marín-Díaz Verónica , Cabero-Almenara Julio , Gallego-Pérez Oscar Manuel
Published: December 2018

La incorporación de herramientas digitales a la enseñanza supone en un gran número de casos una modificación de la actitud del estudiante hacia los contenidos. Así encontramos como la Realidad Aumentada, poco a poco se ha ido incorporando a las aulas, provocando una revolución en la forma de entender las materias a estudiar, generando una mayor motivación por parte del alumnado por desarrollar su proceso de aprendizaje. En el este artículo se presentan los resultados de la aplicación de la RA como recurso potenciador de la motivación por el aprendizaje en un grupo de alumnos de la Universidad de Sevilla del grado de Pedagogía y que cursaban la materia Tecnología Educativa. A través del modelo de Keller (1983) se ha comprobar si la utilización de esta tecnología propiciaba una mayor motivación hacia el estudio. Tras el desarrollo en el aula de una acción de innovación docente, donde los alumnos se convirtieron en consumidores y creadores de materiales  y la posterior aplicación del modelo propuesto, se pudo concluir a través de los resultados alcanzados que los estudiantes participantes mostraron una mayor motivación hacia el aprendizaje de los contenidos de la materia en la que de desarrollo la investigación
Concepciones de los Docentes sobre la Evaluación Socialmente Justa
Authors: Murillo F. Javier , Hidalgo Nina
Published: December 2018

RESUMENEl presente estudio busca conocer las concepciones de docentes sobre una evaluación socialmente justa. Para alcanzar dicho objetivo, se ha llevado a cabo una investigación fenomenográfica en la que han participado 30 docentes de educación Primaria y Secundaria, de centros públicos y privados y situados en contextos socioeconómicos favorables y desafiantes. Los resultados obtenidos muestran que los docentes conciben una evaluación socialmente justa conformada por seis elementos: una evaluación para el aprendizaje (más que del aprendizaje), equitativa y diferenciada para cada estudiante, participativa, que contribuya a la toma de conciencia social, que valore la autoestima y la empatía, y que favorezca y considere la capacidad reflexiva y critica de los estudiantes. Los hallazgos del estudio ponen de manifiesto la importancia de profundizar en concepciones sobre una evaluación socialmente justa del alumnado ya que la práctica evaluativa tiene claras repercusiones en la vida social y académica de los estudiantes.Palabras Clave: Evaluación de estudiantes, Evaluación socialmente justa, Concepciones de evaluación, Investigación fenomenográfica.ABSTRACTThe present study seeks to know assessment teachers’ conceptions about what is a socially just assessment. To achieve this objective, a phenomenographical research has been carried out in which 30 teachers of Primary and Secondary education have participated, from public and private schools located in favourable and challenging contexts. The results obtained show how teachers conceive a socially just assessment consisting of six elements: assessment for learning (rather than learning), equitable and differentiated for each student, that contributes to social awareness, which value self-esteem and empathy, and that favor and consider the reflective and critical capacity of students. The findings of our study show the importance of deepening into conceptions about a socially just assessment of students since assessment practice has clear repercussions in social and academic students’ life.Keywords: Students assessment, Socially just assessment, Assessment conceptions, Phenomenographic research.
Satisfaction degree of English teachers of Preschool and Primary Education in the Principality of Asturias
Authors: Fernández-Costales Alberto , González-Riaño Xosé Antón
Published: December 2018

ABSTRACTThis paper analyses the satisfaction level of teachers of English in Preschool and Primary Education in the Principality of Asturias (Spain). The sample was composed of 238 teachers from 68 schools and the research tool was a 45-item questionnaire. Data were processed with SPSS, and variance analyses were performed to assess the impact of the variables considered. The main results confirm that general satisfaction is rather high, although it is possible to identify improvement proposals in relation to the social recognition of teaching, the professional status and the acknowledgement of the teaching activity by education authorities. In addition, the results show that age, educational stage, and administrative status influence teachers’ satisfaction.Keywords: Teacher satisfaction, English teachers, English as a Foreign Language (EFL), Preschool Education, Primary Education.RESUMENEste trabajo analiza la satisfacción docente de los maestros de Inglés en Educación Infantil y Primaria en el Principado de Asturias. La muestra del estudio incluye a 238 maestros de 68 centros y el instrumento de investigación fue un cuestionario de 45 ítems. Los datos obtenidos fueron procesados con SPSS y se realizaron análisis de la varianza para medir el impacto de las variables consideradas. Los principales resultados confirman que la satisfacción general de los docentes es elevada, aunque es posible identificar propuestas de mejora en relación con el reconocimiento social de la profesión, el estatus profesional, y el reconocimiento de la labor docente por parte de las autoridades educativas. Además, los resultados confirman que la edad, la etapa educativa, y el estatus administrativo tienen influencia en la satisfacción docente.Palabras Clave: Satisfacción docente, maestros de inglés, Inglés como lengua extranjera, Educación Infantil, Educación Primaria.
La publicidad con ojos de niño: imaginarios infantiles y construcción crítica de significados
Authors: Gómez-Montoya Paola Andrea , Castro Zubizarreta Ana , Aguadez Gómez José Ignacio
Published: December 2018

RESUMENEl estudio pretende recoger la mirada infantil sobre la publicidad para comprender qué sentido e influencia tiene en la vida de los niños y en la forma de construir significado a su mundo. Los niños conviven con mensajes publicitarios, de ahí nuestro interés por recoger su mirada al respecto. Para ello, hemos contado con el apoyo voluntario de 184 niños de la ciudad de Cali (Colombia) con edades comprendidas entre los 7 y los 12 años. En esta investigación se empleó la técnica de talleres, que combinó tres actividades participativas involucrando el dibujo, la escritura y la conversación espontánea. Los resultados del estudio evidencian cómo la publicidad se ha asentado silenciosamente en la vida de los niños generando un imaginario infantil que marca un estilo de vida y una cotidianidad consumista. Términos afines a la publicidad desde la perspectiva infantil son fama, consumo y marcas. Conceptos que tienen presencia en sus aspiraciones y proyecciones. El estudio recoge lo que el niño imagina sobre el tema de la publicidad y cómo la apropia invitando a reflexionar sobre el tratamiento y la generación de prácticas educativas que fomenten que los niños lean e interpreten críticamente los mensajes publicitarios.Palabras Clave: Imaginarios, Publicidad, Procesos de escucha, Participación, Infancia.ABSTRACTThe study aims to collect the children’s perspective on advertising to understand what sense and influence advertising has in the lives of children and how to build meaning in their world. The children live with advertising messages, hence our interest to collect their eyes on it. For this, we have had the voluntary support of 184 children from the city of Cali (Colombia) aged between 7 and 12 years old. This research used the workshop technique, which combined three participatory activities involving drawing, writing and spontaneous conversation. The results of the study show how advertising has settled silently in the lives of children generating a childish imagery that marks a lifestyle and a consumerist every day. Terms related to advertising from the perspective of children with fame, consumption and brands. Concepts that have a presence in their aspirations and projections. The study gathers what the child imagines about advertising and how appropriate it inviting to reflect on the treatment and the generation of educational practices that encourage children to read and critically interpret the advertising messages.Keywords: Imaginaries, Advertising, Processes of listening, Participation, Childhood.
Experience of the prp-therapy application in the treatment of patients with gonarthrosis
Authors: Chesnikov S. G. , Rosenberg D. V. , Timoshenko M. E. , Dediaev S. I.
Published: December 2018

Our experience of trauma and orthopedic department shows a high efficiency of using PRP-therapy in the treatment of gonarthrosis. The use of PRP therapy significantly reduces the intensity of the pain syndrome and substantially improves the quality of life of patients with gonarthrosis, and allows acceleration of patients’ rehabilitation.
Recurrent croup in children: problems and ways of their solution
Authors: Abaeva N. G. , Vernigora N. D. , Safronenko L. A. , Karpov V. V. , Lukashevich M. G. , Disenbaeva L. G. , Shapranova N. L. , Golovina E. M.
Published: December 2018

In this review, we analyse morbidity, anamnesis, clinical features, immunological status, catamnesis, treatment options and ways of prevention of acute and recurrent croup in children studied over the past four decades. Based on the accomplished analysis, we stipulate the need for conducting a scientific research on the recurrent croup problem, development of preventive methods and guidelines.
Dexmedetomidine as a part of multimodal analgesia in postoperative period in trauma patients
Authors: Kutsevolova N. V. , Makhno Yu. E. , Kuklenko A. E. , Vasiliauskiene E. V. , Andronova I. V. , Sanchenko M. A. , Dorofeeva E. M. , Magomedova D. A. , Pavlovsky A. S. , Semenikhina E. V.
Published: December 2018

Despite the large arsenal of analgetics acting through different pharmacological mechanisms and the development of various anesthesia methods, the problem of postoperative pain treatment still remains urgent. Providing a complete pain relief after a surgery remains a desired, but not always a reachable goal. According to the literature, 30 to 75% of patients undergoing surgery suffer from the severe pain syndrome in the postoperative period. This article presents the experience with the use of a prolonged intravenous infusion of Dexmedetomidine as a part of multimodal analgesia in patients who underwent endoprosthetic replacement of large joints.
Adipokine status in patients with stable ischemic heart disease associated with affective disorders
Authors: Dorofeeva N. P. , Ter-Akopyan A. O. , Оrekhova Yu. N. , Ivanchenko D. N. , Shlyk S. V. , Mashtalova O. G. , Kulikova I. E. , Chibineva S. A. , Sklyarov F. V. , Pleskachev А. S.
Published: December 2018

One of the factors negatively affecting the cardiac prognosis of coronary heart disease (CHD) is affective disorders of the depressive spectrum. Symptoms of depression may increase the level of systemic inflammation and promote disorders of carbohydrate metabolism by altering the synthesis and secretion of adipokines: leptin, resistin, adiponectin. The aim of this study was to assess the adipokin status in patients with stable coronary artery disease in the conditions of conservative therapy and during percutaneous coronary interventions (PCI) with stenting, including patients with depressive symptoms. The presence of depressive symptoms was accompanied by an increase in the level of resistin in the blood plasma in patients with stable ischemic heart disease. PCI with coronary artery stenting resulted in an increase in the concentration of all the adipokines: adiponectin, leptin, resistin. Stenting of coronary arteries in people with depressive symptoms led to an increase in the level of resistin, adiponectin with a decrease in the concentration of leptin in the blood plasma on the third day after the operative intervention.
Decoding neonatal chest radiographic patterns of disease: retrospective analysis from a tertiary care hospital
Authors: Ghasi Rohini Gupta
Published: December 2018

Background: To evaluate chest radiographic patterns in neonatal respiratory distress using a predesigned performa and algorithm and to correlate results with the clinical diagnosis.Methods: A retrospective review was done of bedside chest radiographs acquired over a month for respiratory distress from the neonatal intensive care unit. The radiographs were systematically evaluated according to a predesigned performa and algorithm. A presumptive radiographic diagnosis was assigned to each patient based on the combination of radiographic features. Radiographic diagnosis was compared with the clinical diagnosis. The most important diagnostic features were outlined.Results: The radiographic diagnosis correlated with clinical diagnosis in 93.3% of cases. Most common radiographic feature was pulmonary air space opacity (n=21). Air space opacity without any mediastinal shift in absence of any compensatory factors was a reliable diagnostic feature for pneumonic consolidation, which was the most common diagnosis (n=10). Bilateral granular lung fields were a specific indicator of respiratory distress syndrome. Flattening of domes of diaphragm was the most frequent feature for hyperinflation. Bilateral hyperinflation could be accurately used to diagnose bronchiolitis in all but one case (n=4/5). Pleural complications were accurately diagnosed.Conclusions: Systematic evaluation of neonatal chest radiographic patterns of disease has a high diagnostic accuracy.
Efficacy of autologous platelet rich plasma over conventional mechanical fixation methods in split thickness skin grafting
Authors: Thimmanahalli Girish Umashankar , Kumar Mahesh
Published: December 2018

Background: Platelet-Rich Plasma (PRP) is an autologous product derived from whole blood through the process of gradient density centrifugation. After skin graft reconstruction, the healing process is longer and may be difficult, depending on the wound site, skin defect size, and patient comorbidities. The potential value of PRP lies in its ability to incorporate high concentrations of platelet-derived growth factors into the skin graft. Since not all patients afford commercially available recombinant platelet rich plasma for skin graft, platelet extract from patient’s own blood is being used in this study to test and demonstrate the therapeutic role of PRP in skin graft. The aim of this randomized, prospective study is to compare the effectiveness of PRP in skin graft with conventional method like sutures, staplers or glue.Methods: The source of data were the patients admitted as inpatients for the management of wounds to the department of general surgery, JSS Hospital, Mysore from September 2016 to September 2018. Total of 60 patients were studied; 30 cases were randomly chosen for study with autologous platelet rich plasma and 30 cases received conventional methods like staples/sutures used to anchor the skin grafts in a control group.Results: Autologous PRP showed faster and better healing rates. With PRP study group instant graft adherence was seen in all cases. Hematoma, graft edema, discharge from graft site, frequency of dressings and duration of stay in hospital were significantly less in the PRP. There were no adverse effects or reactions seen with the use of autologous PRP among the study group.Conclusions: The combination of PRP with Split Thickness Skin Graft (STSG) significantly improved clinical outcomes and shortened the wound healing time. Therefore, this treatment combination could provide a way to heal skin after skin graft reconstruction with minimal recovery time. It is found to be highly beneficial in many aspects both to the patient and surgeon based on our results.
Конкурентоспособность организаций малого бизнеса в сфере торговли
Authors: Брагин Леонид Александрович , Панкина Татьяна Викторовна , Никишин Александр Федорович
Published: December 2018

В статье проведен анализ современного состояния малого бизнеса в России, выявлены основные тенденции его развития. Проанализирована роль сферы торговли в развитии малого бизнеса в России, рассмотрена динамика и структура малого торгового бизнеса. Среди основных направлений повышения конкурентоспособности малых торговых предприятий определены такие как выбор местоположения торгового предприятия, управление ассортиментом с учетом специфики малого бизнеса, повышение качества обслуживания, а также применение инструментов электронной торговли.
Аналитические возможности в управлении ассортиментом торговой организации
Authors: Гришина Вера Тихоновна , Калугина Светлана Афанасьевна
Published: December 2018

Обоснована необходимость регулярного анализа в решении вопросов по управлению ассортиментом торговой организации. На обширных фактических данных о продаже шести категорий обоев торговой организации продемонстрированы возможности АВС- и XYZ- анализа в управлении ассортиментом. Убедительно представлены преимущества одновременного применения указанных методов с последующим совмещением выделенных групп исследуемого ассортимента.
Поколения потребителей и их влияние на ассортимент в торговле
Authors: Каращук Оксана Сергеевна , Майорова Елена Александровна
Published: December 2018

В статье рассматриваются проблемы изменения спроса на торговый ассортимент в России вследствие происходящей смены поколений потребителей, предпочтения которых имеют существенные особенности. В рамках исследования поставлены следующие задачи: на основе теоретического анализа существующих поколенческих моделей сформулировать характеристики предпочтений отдельных возрастных групп потребителей; проанализировать изменения возрастной структуры населения Российской Федерации и выявить его влияние на торговый ассортимент. Результаты анализа изменения возрастной структуры населения Российской Федерации с учетом потребительских предпочтений разных поколений показали, что в долгосрочной перспективе на российском рынке сохранится высокая доля сегмента товаров эконом-класса. Более того, после 2031 г. ожидается расширение указанного сегмента за счет естественного роста доли населения поколения «миллениалов» (18-34 лет) и «беби-бумеров» (56-78 лет) и снижения доли поколения «революционеров» (35-55 лет) в общей численности населения государства.
Обеспечение опережающего развития торговли России зерновой продукцией
Authors: Каращук Оксана Сергеевна
Published: December 2018

Актуальность статьи определяется наличием в России нереализованных возможностей для дальнейшего увеличения объемов производства и продажи зерновой продукции. Благоприятная для нашей страны конъюнктура мирового рынка зерна создает хорошие условия для увеличения доли России в мировых продажах данной продукции. Преодоление в отечественной практике экстенсивного производства и выход на инновационный путь развития, а также изменение состава экспорта в пользу продукции переработки зерна может стать основой для развития торговли России зерновыми товарами на внутреннем и внешнем рынках. Для опережающего роста российской торговли зерновой продукцией в работе предлагается обеспечить комплексную государственную поддержку производителям и продавцам зерновой продукции, которые: наращивают выпуск и реализацию пшеницы, кукурузы и ячменя твердых сортов и ценных видов; ориентируются на интенсивное развитие производственной и торговой деятельности; формируют комплексное предложение для импортеров, в том числе на основе продукции переработки зерна и новых нетрадиционных для России видов зерновых.
Совершенствование системы доставки товаров в коммерческой деятельности торговых предприятий
Authors: Леонова Юлия Геннадьевна , Языков Даниил Андреевич
Published: December 2018

В предлагаемой статье авторы освещают перспективы практического применения актуальных направлений совершенствования системы доставки товаров в торговых предприятиях в ракурсе влияния современных рыночных тенденций. Экономически целесообразная организация процедуры доставки товаров покупателям выступает одним из ключевых аспектов коммерческой деятельности, определяющим ее общую результативность, динамику ключевых показателей развития. В статье рассматриваются организационно-экономические аспекты процесса доставки товаров в деятельности конкретного торгового предприятия, проводится экономический анализ структуры и динамики его расходов на доставку товаров, предлагается комплекс мероприятий, призванных оптимизировать сложившуюся на предприятии процедуру доставки товаров с учетом современных трендов развития транспортно-логистической сферы, приводится экономическое обоснование эффективности предлагаемых решений.
Оптимизация цепи поставок продукции через сеть распределительных центров
Authors: Слепенкова Елена Васильевна , Муртузалиева Таира Велимагомедовна , Сейфуллаева Маиса Эмировна
Published: December 2018

В статье рассматриваются вопросы выстраивания цепей поставок продукции крупным производителем, который функционирует на российском рынке «Нестле Россия». Данный производитель формирует цепь распределения продукции, в первую очередь, через дистрибуторов, которые определяют, на каких территориальных логистических площадках будет осуществляться реализация, хранения и куда будет поставляться продукция. Особенное внимание в статье уделено транспортно-складским затратным составляющим при определении местоположения распределительного центра.
Оценка емкости и перспектив развития B2C-рынка мяса и мясо-продуктов РФ
Authors: Рамазанов Ибрагим Агаевич , Калугина Светлана Афанасьевна , Майорова Елена Александровна
Published: December 2018

Оценивается емкость российского B2C-рынка отдельных видов мяса и основных продуктов их переработки в контексте перемен, происходящих в традициях потребления россиян. Прогнозируется обострение конкуренции на рынке говядины между зарубежными участниками рынка, увеличение потребления и расширения доли баранины на потребительском рынке. Доказано сокращение потребления и сужения емкости рынка свинины в пользу говядины и баранины. Прогнозируется сокращение потребления колбасных изделий и субпродуктов по причине перемен, происходящих в поведении потребителей. Предложение мяса птицы из внутренних источников достигает своего предела.
Инвестиционный потенциал региона как фактор экономического роста
Authors: Митяева Ольга Александровна , Швецов Сергей Алексеевич , Ильяшенко Светлана Борисовна
Published: December 2018

Российская экономика базируется на необходимости реализации концентрации усилий государства, предпринимателей и населения на освоении конкурентоспособных технологий и товаров, повышении эффективности интеграционных процессов, роста деловой активности, что обеспечит высокие темпы роста экономического и социального развития в условиях экономической неопределенности. На сегодняшний день перед регионами довольно остро стоит проблема поиска источников финансирования. В частности, в статье проанализированы основные факторы инвестиционной привлекательности Тульской области, среди которых определены такие как экономико-географическое положение, ресурсно-сырьевой потенциал, производственный потенциал. Особое внимание уделено оценке инфраструктурной обеспеченности региона и основным направлениям инвестиционной поддержки предпринимательского сектора.
Особенности торговли продуктами для здорового питания
Authors: Казанцева Св Светлана Юрьевна
Published: December 2018

Рассмотрен анализ современного состояния сферы торговли продуктами для здорового питания, оценены как его современное состояние, так и возможные перспективы. Идентифицированы угрозы и возможности внешнего среды предприятий, занятых торговлей продуктами для здорового питания. В качестве примера рассмотрена сеть магазинов продажи продуктов для здорового питания, включающая в себя магазины под торговыми марками «Избёнка» и «ВкусВилл». Также рассмотрен пример Казахстана с точки зрения современного состояния и перспектив развития сегмента продажи продуктов для здорового питания.
Как встроить малый торговый бизнес России в новую экономическую реальность
Authors: Чеглов Вячеслав Петрович , Столярова Алла Николаевна
Published: December 2018

Статья посвящена анализу трансформационных процессов, происходящих в торговой сфере России, их влиянию на отечественный малый бизнес, конечного потребителя. Показано изменение парадигмы развития торговой сферы, глубокая дифференциация в оптовом и розничном звеньях, в результате которой малые предприятия оказались неконкурентоспособными, уязвимыми на рынке. Обоснован объективный характер замещения семейного предприятия системным, инвестиционным бизнесом. Дана характеристика новой социально - экономическая реальности, связанной с тем, что множество предпринимателей вынуждены выходить из бизнеса и становиться рантье или наемными менеджерами. Исследована роль и перспективы малого торгового бизнеса в новой экономической реальности, формулируются направления достижения баланса в развитии крупного и малого бизнеса. Предложены конкретные инструменты объединения и инкорпорирования средних и малых торговых предприятий в целях достижения их конкурентоспособности на рынке. Обоснованы новые подходы государственного регулирования интеграционных процессов во внутренней торговле, позволяющие сгладить давление системного бизнеса на рынок и трансформировать внесистемные предприятия.
Фальсификация продовольственных товаров как одна из проблем современной торговли
Authors: Панасенко Светлана Викторовна , Мазунина Татьяна Александровна , Воронина Эмма Васильевна
Published: December 2018

Проведен анализ современного состояния фальсификации продовольственных товаров в сфере розничной торговли, предложены меры, позволяющие снизить и постепенно исключить реализацию фальсифицированных продовольственных товаров. Основной акцент сделан на выявлении фальсификации молочной продукции и продукции, предназначенной для детского питания. Среди основных направлений снижения уровня фальсификации отмечены: совершенствование договорной работы с поставщиками, усиление требований к товарно-сопроводительным документам, подтверждающим безопасность товаров, а также совершенствование законодательных документов путем внесения в них поправок.
A biobibliographical sketch of a naturalist turned rhodologist: François Crépin (1830-1903)
Authors: Hoste Ivan , Diagre-Vanderpelen Denis
Published: December 2018

Born in Rochefort, in the Belgian Ardennes, François Crépin (1830-1903) soon developed a taste for wild plants, yet he never received a formal training in botany. By the late 1850s, still without a job but living with his parents, the ambitious naturalist had built a large network of correspondents that included botanists in Belgium and abroad. His Manuel de la flore de Belgique, published in 1860, was an immediate and lasting success and yielded him a job as a teacher and a place in the inner circles of Belgian field botany. In the decades following its creation, in 1862, he dominated the Société royale de Botanique de Belgique and wrote numerous book reviews and papers on the flora and biogeography of Belgium. In the late 1860s, his career took a turn: he embraced the idea of evolution and started work on a world monograph of the genus Rosawhich unfortunately remained unfinished. Although rhodologists had described thousands of species, Crépin arrived at a natural classification that included no more than ca. 60 species. Before becoming director of the State Botanic Garden in Brussels, in 1876, he also did research on paleobotany.
Boekbesprekingen / Comptes rendus
Authors: Ter Sluis Rolf , Meskens Ad , Meerwijk Maurits , Theunissen Bert , Vanpaemel Geert , Vermeer Leonieke , Kleemans Machiel , Deelstra Hendrik , Van Lunteren Frans
Published: December 2018

Esther van Gelder, Erik Jorink , Ilja Nieuwland, Marlise Rijks en Alice Spruit (red.), ‘Dingen die ergens toe dienen.’ Verhalen over materiële cultuur van wetenschap(Hilversum: Verloren, 2017), 192 pp., ill., ISBN 9789087046958. € 25. (Rolf ter Sluis)Galileo Galilei, Kijker, Kerk en Kosmos. Galileo Galilei’s ‘Bericht van de sterren’ en ‘Brief aan groothertogin Christina’, vertaald en ingeleid door Margriet Agricola, Albert van Helden en Steven van Impe (Amsterdam: Athenaeum-Polak & Van Gennep, 2017) ISBN: 9789025308384. € 19,99. (Ad Meskens)Stephen Snelders, Leprosy and colonialism. Suriname under Dutch rule, 1750 – 1950(Manchester: Manchester University Press, 2017), 288 pp., ISBN: 9781526112996. £75. (Maurits Bastiaan Meerwijk)Bert Sliggers, De verzamelwoede van Martinus van Marum (1750-1837) en de ouderdom van de aarde. Herkomst en functie van het Paleontologisch en Mineralogisch Kabinet van Teylers Museum(onuitgegeven proefschrift Universiteit Leiden, 2017). (Bert Theunissen)Klaas van Berkel, Universiteit van het Noorden. Vier eeuwen academisch leven in Groningen. Deel 2. De klassieke universiteit 1876-1945(Hilversum: Verloren, 2017), 832 pp., ill., ISBN  9789087046811. € 49. (Geert Vanpaemel)Ingrid Kloosterman, Wetenschap van gene zijde. Geschiedenis van de Nederlandse parapsychologie(Amsterdam: Boom, 2017), 326 pp., ISBN: 9789024405930. € 24,90. (Leonieke Vermeer)Abel Streefland, Jaap Kistemaker en uraniumverrijking in Nederland, 1945-1962(Amsterdam: Prometheus, 2017), 320 pp., ISBN: 9789044634136. € 29,99. (Machiel Kleemans)Charles Jaumotte en René Noël, 50 ans d'histoire universitaire à Namur: des Facultés Universitaires Notre-Dame de la Paix (FUNDP) à l'Université de Namur, 1965-2015(Namen: Presses universitaires de Namur, 2017), 412 pp., ill., ISBN 9782870379035. €35. (Hendrik Deelstra)Govert Schilling, Deining in de Ruimtetijd. Einstein, zwaartekrachtgolven en de toekomst van de astronomie(Hilversum: Fontaine Uitgevers, 2017), 366 pp., ISBN 9789059567603. € 24,95 (Frans van Lunteren)
Quantitative and Qualitative Analysis of the Learning Analytics and Knowledge Conference 2018
Authors: Ochoa Xavier , Merceron Agathe
Published: December 2018

Editorial of the Special Section of LAK-18
MODERN TRENDS AND PROSPECTS OF DEVELOPMENT OF RUSSIAN AGRARIAN SCIENCE
Authors: Soldatenko A. V. , Musayev F. B.
Published: December 2018

The 4th All-Russian Scientific and Practical Conference "Innovative technologies in the field of genetics, breeding, seed production and reproduction of plants" was held in the Nikitsky Botanical Garden on September 3-10, 2017 with the support of the Russian Academy of Sciences, the Ministry of Science and Higher Education, the Ministry of Agriculture. Over 330 scientists attended the forum from regions of Russia and foreign countries. According to the results of the conference, a resolution was adopted on the future development of domestic seed production with a view to import substitution in the crop sector.
SELECTION TO FEMALE TYPE OF FLOWERING OF CUCUMBER HYBRIDS FOR THE WINTER GREENHOUSES
Authors: Korottseva I. B. , Kochetkova L. A.
Published: December 2018

The possibility of obtaining parthenocarpic hybrids of the female F1 cucumber type in combination with paternal forms of various sexual types – intermediate and predominantly female – has been studied. The research was carried out for four years – 2015-2018, in the winter greenhouse of the "Richelieu" type, in the winterspring turnover, with low-volume cultivation technology. In the competitive and preliminary tests, more than 100 promising hybrid combinations were studied. As a result of the research, it was revealed that the sexual type of perspective parthenocarpic cucumber hybrids for the winter-spring rotation depends on the genotype of the original parental forms. The use of predominantly female-type flowering as paternal forms led to an increase in the female F1 hybrids. In a combination of maternal female-type forms with male-type paternal forms, hybrids of the female sex-type cucumber were obtained, but much less frequently than from crossing with the predominantly female types of flowering. According to the results of the competitive variety testing, two promising hybrids of the cucumber – Murava F1 and Vera F1 were transferred to the state variety testing in 2017. These hybrids were created using the paternal forms of a predominantly female type of flowering.