bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of humanitarian values on the architectural development in the Monastery of Temptation
Authors: Shehada Ziad M. M.
Published: October 2023

The significance of architecture extends beyond its mere visual and practical aspects, as it significantly shapes human lifestyles and societal dynamics. Its role transcends aesthetics and utility, actively catering to essential requirements and elevating living standards worldwide. One particular example of such architectural prominence lies in Palestine, near Jericho, where the Monastery of Temptation, a Greek Orthodox religious site, is situated. Positioned at an elevation of 350 meters above sea level on the slopes of the Mount of Temptation, the monastery commands a cliff-top vantage, offering panoramic views of the Jordan Valley and the city of Jericho. Its historical roots date back to the sixth century CE, with the initial construction of various structures in the vicinity. The primary objective of this scholarly inquiry is to examine and comprehend the impact of humanitarian principles on the architectural evolution of the Monastery of Temptation throughout its history. This investigation adopts a historical interpretive approach, drawing from a review of pertinent literature and preliminary research. The findings of this study reveal that the architectural design of the monastery has been thoughtfully crafted to harmonize with ecological equilibrium and uphold core human values. Additionally, it serves as a secure haven for the observance of religious rituals and ceremonies, warranting its inclusion in the Tentative List of World Heritage sites. Consequently, this research endeavor contributes to a profound and meticulous grasp of the intrinsic nature of the Monastery of Temptation, with far-reaching implications for fostering the growth of the regional tourism industry.
ABORDAGEM QUALITATIVA EM PESQUISAS EDUCACIONAIS: padrões em dissertações de programa de pós-graduação de excelência
Authors: Conde Ivo Batista , Carvalho Scarlett O’hara Costa
Published: October 2023

Adentrar nos meandros da pesquisa educacional, compreender padrões em seus pressupostos metodológicos, suas características procedimentais mais recorrentes, precisamente, como se obtém os dados que sustentam a investigação na área é baliza do presente estudo. O foco da pesquisa centrou-se nas produções de mestrado dos anos de 2013 a 2018 de um programa de pós-graduação em educação avaliado pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes/MEC) com conceito 7 (sete).  Como problema da pesquisa questionou-se como as dissertações de mestrado, com abordagem qualitativa, de um programa de pós-graduação em educação conceito 7, explanam sua metodologia e técnicas para coleta de dados. A partir de uma pesquisa documental realizada na Plataforma Sucupira, com o recorte temporal delimitado, identificamos 98 dissertações, sendo 96 caracterizadas como qualitativa, 01 quantitativa e 01 mista. Desse modo, o presente artigo objetiva identificar os padrões metodológicos para área de educação em dissertações no período de 2013 a 2018, de um programa de pós-graduação em educação conceito 7. Constatou-se ampla predominância da abordagem qualitativa nas pesquisas educacionais. Percebeu-se também que em relação ao método, o Estudo de Caso, a Pesquisa Documental e a História Oral têm significativa frequência sobre as demais e no que concerne às técnicas para coleta de dados, a entrevista se sobressai. Por fim, verificou-se, ainda a falta de definição do método de investigação em um número significativo de dissertações.
DIGITAL APPROACH TO TEACH CREATIVE WRITING WITH SECONDARY STUDENT LEARNERS OF ENGLISH
Authors: Rocha Ana Paula , Casanova Maria Prazeres
Published: October 2023

In this article, we share our reflections and analysis on the potential of digital resources in teaching creative writing in English and promoting the learning of a foreign language in a collaborative environment. Our work aims to identify best practices in using digital tools such as Google Workspace, Padlet, and Issuu, for in-class activities with seventy secondary students. We conducted a study following an action-research methodology in the classroom and applied digital teaching strategies with learners of a second language. The focus was on a creative and collaborative writing process, to develop imagination in the conception of fictional stories while promoting collaborative skills. Our key question was "What are the digital pedagogical strategies that can contribute to the creative and collaborative writing competence in a foreign language with secondary school students?" We were interested in examining the potential of a writing collaborative activity in a digital environment as a stimulus to learn the linguistic rules and expand the vocabulary. Additionally, we analyzed the results of the assessment executed among peers, applying selected rubrics for the competencies of cooperation and participation. As a result, we found that the students had reached a higher level of reflection towards texts.
EXPLORING THE INFLUENCE OF CONVERGENT COMMUNITIES ON LEARNERS’ ATTITUDES TOWARD DIVERGENT TRAITS
Authors: Belaid Louiza
Published: October 2023

The cultural context of speech communities represents people’s life experiences shaped by region, geography, ethnicity, language, and values; all these contribute to the construction of one’s identity. Our study explores the complex reciprocity between the socio-cultural environment and the learners’ identities. The cultural background of learners profoundly affects self-perception and identity construction. Simultaneously, identity construction has a reciprocal effect on interaction and involvement with cultural heritage. Hence, we investigate the impact of rural communities’ cultural repertoire on the personal and professional prospects of learners. To reach this end, third-year pupils from the High School of Sidi Housni, Tiaret, Algeria were selected using a non-probabilistic sampling. We collected data through a survey and an observation, employing both quantitative and qualitative approaches. The findings reveal that the cultural background influences learners’ perceptions of the world, besides their positive divergent attitudes towards gender roles. Furthermore, these valuable insights have important implications for cultivating a more inclusive and flexible learning setting. In a nutshell, divergent and convergent communities possess distinct qualities and resources that collectively foster a gradual transition toward embracing change.
Giddens’ structuration theory and human resource practice in small firms
Authors: Tretiakov Alexi , Jurado Tanya , Bensemann Jo
Published: October 2023

We studied HR practices in New Zealand small and medium enterprises (SMEs) by analysing semi-structured interviews with 48 SME owners-managers using Giddens’ structuration theory as an analysis lens. HR practices were shaped by routinised actions of actors, and employee agency was strong, as action (or lack of it) by a single employee could have implications for the whole firm. Employees were not purely economic agents, as the quality of work experience and family circumstances could shape their behaviour more than financial compensation. HR practices were reproduced through the reflexive actions of owners-managers, employees and their family members as well as of external agents, such as suppliers and regulators. The analysis suggests that, to implement HR practices, such as hiring, employee development, and employee retention/dismissal in small firms successfully, owners-managers should treat employees and members of their families as powerful actors co-creating, rather than merely being subject to, HR practices.
Towards the platformisation of employment in post-pandemic Aotearoa New Zealand? Evidence from the Future Worlds of Work survey
Authors: Salter Leon
Published: October 2023

It has been widely recognised in the international literature that the impacts of the pandemic on workers have been experienced unevenly, most severely affecting women, minorities, and those on insecure contracts. At the same time, Covid-19 has accelerated technologically driven developments such as platform work and online freelancing. To provide evidence for these shifts in Aotearoa New Zealand, a survey (n=570) was completed by a sample aged over 18 and employed in the previous 12 months. The survey found uneven experiences of pandemic-related disruption, particularly for those in insecure forms of work, Māori, and frontline workers in hospitality and retail. Further, there was evidence for the emergence of a culture of “digital hustling” among younger people, who are seeking supplementary forms of income from the online world, while 43 per cent of respondents with an employment agreement were required to use a smartphone as part of their job. I use these findings to develop the concept of platformisation, capturing broad impacts of digital technology on workplaces, together with trends towards precarity and individual responsibility. The results have implications for public policy analyses of a “tight labour market” which can negate the unevenly felt effects of an economic slowdown.
Aplicación de estrategias bioclimáticas para la adecuación de los espacios del Centro Cultural Futurama, GAM, CDMX
Authors:   , Cadena Durán Raymundo Ángel
Published: October 2023

La intención de este trabajo, es analizar de principio la problemática con la que nos enfrentamos en edificios ya construidos que por su valor histórico son rescatados y a su vez estos son reacondicionados para desarrollar nuevas actividades para lo que fueron diseñados de un inicio. Para este caso particular se eligió el predio denominado Centro Cultural Futurama antes cine Futurama. Se realizó el siguiente análisis para reacondicionar la galería alta, mejorando las condiciones existentes y lograr que esta pueda albergar colecciones privadas, las cuales requieren condiciones específicas para ser exhibidas. El contenido de la presente investigación se realiza conforme a los requerimientos bioclimáticos para la Ciudad de México. Se realizó el análisis del sitio, el estudio del medio natural, el medio artificial y los requerimientos de confort del usuario para dicho espacio Galería Alta. Toda esta investigación se llevó a cabo con fines de mejorar el espacio, la información obtenida fue sometida a pruebas, por medio de software especializados que nos ayudan a comprobar que las soluciones e implementaciones de dispositivos fueron los correctos o estos tengan que ser sometidos a nuevas modificaciones para tener los índices correctos de confort al interior.
Aplicación de estrategias bioclimáticas para la adecuación de los espacios del Centro Cultural “Futurama” en GAM, CDMX
Authors:   , Castro López Anakaren
Published: October 2023

En este trabajo se presenta el estudio para el acondicionamiento bioclimático del Centro Cultural “Futurama” ubicado en la CDMX inaugurado en 1969. Ubicado en la alcaldía Gustavo A. Madero de la CDMX. Esta edificación alberga actividades de recreación, exposiciones de distintas artes, conferencias, obras de teatro, recitales de danza, conciertos, etc. Dichas actividades se llevan a cabo en áreas construidas para distintos fines y por ello presentan problemáticas de distintos tipos, como lumínicas, acústicas, térmicas y de ventilación. Lamentablemente este edificio se construyó para otros fines distintos a los que en este momento se realizan, esto provoca que su diseño en sí no sea nada eficiente y los elementos climáticos se vuelven contraproducentes para los usuarios que ocupan por lapsos más amplios este edificio. Las edificaciones provocan un impacto en el medio ambiente y, por ende, en la salud de las personas y además contribuyen al cambio climático. México sufre de manera cada vez más obvia los efectos del calentamiento global, por ello, los expertos plantean que hay que adoptar lo antes posible políticas encaminadas a prevenir el impacto ambiental y si en una edificación no se pudo crear desde el inicio un diseño bioclimático, como es el caso del Futurama, podemos aportar con estrategias bioclimáticas en las edificaciones ya construidas. Las recomendaciones bioclimáticas aportadas en este proyecto tienen como objetivo central el que el ahorro de energía, con base en la arquitectura bioclimática, la cual se fundamenta en el análisis de los climas de México para determinar las condiciones y requerimientos de climatización. Estas estrategias bioclimáticas se plantearon para mejorar el confort de los usuarios, aprovechando la situación climática del sitio y dejar en última opción los medios artificiales y en los casos que se deben utilizar se mencionan consejos para usar equipos de tecnología eficiente. El área que decidí estudiar por mayor cantidad de usuarios y por el tiempo de ocupación fue el de las oficinas administrativas. En estas laboran alrededor de 20 personas en un horario de 8:00 a 18:00.
PENGARUH CLICKBAIT PODCAST DEDDY CORBUZIER TERHADAP MINAT MENONTON (Survei Pada Mahasiswa Prodi Ilmu Komunikasi UMJ Angkatan 2017)
Authors: Wikatri Azhaari Fairuz , Shabana Amin
Published: October 2023

Adanya perkembangan teknologi membuat masyarakat banyak beralih profesi sebagai content creator. Salah satu content creator yang memanfaatkan platform youtube dan banyak ditonton adalah Deddy Corbuzier. Salah satu konten ber clickbait berjudul “Bukan Clickbait!! Tersebar Buku Pembunuhan Ini!! Tonton Sebarkan!!”. Tujuan penelitian ini mengetahui seberapa besar pengaruh clickbait podcast Deddy Corbuzier khususnya terhadap minat menonton mahasiswa prodi ilmu komunikasi Universitas Muhammadiyah Jakarta Angkatan 2017. Teori yang digunakan peneliti adalah clickbait dengan delapan elemen antaralain: Exaggeration, Inflammatory, Formatting, Teasing, Graphic, Bait-and-Switch, Ambiguous, Wrong, serta tiga elemen dalam minat menonton yaitu: Kognitif, Afektif, Konatif. Penelitian ini merupakan penelitian kuantitatif. Metode penelitian yang digunakan yaitu metode survei yang bersifat deskriptif, yang dilakukan dengan cara menyebarkan kuisioner melalui whatsapp grup dan chat. Metode pengambilan kuisioner yang dilakukan ialah simple random sampling. Hasil dari penelitian ini menunjukkan bahwa pengaruh clickbait podcast Deddy Corbuzier, secara keseluruhan responden merespon baik (setuju), dan pengaruh clickbait terhadap minat menonton secara keseluruhan responden merespon 78,4% baik (setuju) dari semua pernyataan variabel (Y) dalam seluruh kuisioner penelitian. Hasil dari penelitian menyatakan bahwa besarnya pengaruh clickbait podcast Deddy Corbuzier memiliki hubungan positif dan kuat sebesar 0,784 terhadap minat menonton mahasiswa Universitas Muhammadiyah Jakarta Prodi Ilmu Komunikasi Angkatan 2017, dengan persentase clickbait memiliki pengaruh terhadap minat menonton sebesar 61,4% sementara sisanya 38,6% dipengaruhi oleh faktor lain.
PENGARUH BRAND ACTIVATION TRI INDONESIA DI INSTAGRAM TERHADAP MINAT BELI PERDANA H3RO
Authors: Putri Bias Agprisyanda , KN Jamiati
Published: October 2023

Salah satu perusahaan telekomunikasi yang memberikan layanan khusus untuk bermain game mobile, yaitu Tri Indonesia dengan mengeluarkan perdana H3RO. Tujuan dari penelitian ini untuk mengukur brand activation yang dilakukan Tri Indonesia di Instagram pada followers Tri Indonesia, minat beli perdana H3RO pada followers akun Instagram Tri Indonesia, pengaruh brand activation di Instagram Tri Indonesia terhadap minat beli perdana H3RO. Teori yang digunakan adalah brand activation meliputi sense, feel/relate, think, dan act serta minat beli meliputi transaksional, referensial, preferensial, dan eksploratif. Pendekatan dalam penelitian ini adalah kuantitatif dengan metode survey. Teknik pengumpulan data dengan menyebarkan kuesioner yang diberikan kepada 95 responden pada followers akun Instagram @triindonesia. Pengambilan sampel menggunakan teknik probability sampling dengan metode simple random sampling. Hasil dari penelitian ini menunjukkan bahwa pengaruh Brand Activation Tri Indonesia di Instagram secara keseluruhan responden merespon setuju, serta peengaruh Brand Activation terhadap Minat Beli secara keseluruhan responden merespon setuju dari semua pernyataan variabel Y di kuesioner penelitian, dan besarnya pengaruh Brand Activation Tri Indonesia di Instagram memiliki hubungan positif dan kuat sebesar 0,663 terhadap minat beli perdana H3RO pada followers Instagram @triindonesia dengan presentase Brand Activation mempengaruhi Minat Beli sebesar 44% dan sementara sisanya 56% dipengaruhi oleh faktor lain.
Gobernanza y financiación de museos: análisis comparado de las modalidades existentes en los Estados Unidos de América y en los museos españoles de titularidad estatal
Authors: Vadillo Lobo Elena
Published: October 2023

Contexto: En el marco del interés creciente por implicar a la sociedad en el sostenimiento de los museos de titularidad estatal en España, el modelo privado de gobernanza y financiación estadounidense, junto con el sistema de museos públicos de la Smithsonian Institution, proporcionan una amplia perspectiva para afrontar el futuro de la sostenibilidad económica en los museos públicos. Con el objetivo de inspirar un nuevo acercamiento a la gestión de los museos estatales en España, este artículo resulta pionero en analizar la financiación de estas instituciones culturales desde la perspectiva de la restricción de gasto asociada a cada fuente de ingresos, y su relevancia para construir un modelo financiero diversificado. Metodología: El método empleado se basa en el análisis de fuentes primarias (memorias anuales y documentación contable de los museos, normativa aplicable a la política pública museística en España) y fuentes secundarias procedentes de la extensa literatura estadounidense de gestión museístico-financiera, y de las escasas publicaciones sobre esta temática en España. Resultados: La comparativa practicada pone de manifiesto tanto las similitudes entre modelos españoles y estadounidenses aparentemente opuestos, como las marcadas diferencias en cuanto a posibilidades de financiación existentes dentro de los museos de titularidad estatal, distinguiendo entre aquellos gestionados por la Subdirección General de Museos Estatales, y los museos con estatuto propio. Estos últimos han caminado hacia la diversificación de fuentes de ingresos, a través de actividades comerciales propias, convergiendo parcialmente con la dinámica de los museos estadounidenses. Conclusiones: Este artículo concluye con la propuesta de diversas líneas de actuación para promover el incremento de la financiación privada en los museos de titularidad estatal, incidiendo sobre la estructura de liderazgo colegiado, su vinculación con la financiación del museo, la naturaleza de aquellas fuentes de financiación claves, o el empleo de las técnicas de marketing y fundraising, entre otros aspectos.
Effect of Mycorrhizae Inoculation and Maggot Compost on Sunflower Development on Marginal Land
Authors: Obel Obel , Erona Meisilva
Published: October 2023

The use of inorganic fertilizers for a long time has an adverse impact on soil quality and the environment. For this reason, an agricultural approach that uses potential natural resources is needed. One of them is by applying agriculture in an organic concept that utilizes biological materials such as mycorrhiza and the addition of maggot compost. The purpose of this study was to determine the effect of mycorrhizal inoculation and maggot compost on the development of sunflowers on marginal land. In practice, the study used a randomized block design consisting of two factors, namely mycorrhizal inoculum and maggot compost which was repeated 3 times. The results of the study showed that mycorrhizal inoculation and maggot compost had an influence on the development of sunflowers such as the time of full bloom, ribbon flower diameter, tube flower diameter, number of seeds planted and weight of 100 seeds on marginal land. the higher the dose of mycorrhiza and maggot compost applied, the increase in each parameter observed in sunflower development on marginal land.
Effect of Activator Types on the Production of Activated Carbon from Cocoa (Theobroma cacao, L.) Pod Husk as Metal Adsorbent
Authors: Aisman Aisman , Ismanto Sahadi Didi , Aprilianda Nadila
Published: October 2023

The objective of this study is to investigate the distinctive properties of activated carbon derived from cocoa pod husks that have been activated using various activators. The study seeks to assess the absorption capacity of the resulting activated carbon for the heavy metal Fe, and to identify the most effective activator for this purpose. The activators used were ZnCl2, H3PO4, KOH, and MgCl2 each at a concentration of 10%. The characteristics of the activated carbon produced include; yield 70.18–82.24%, water content 0.75–2.25%, ash content 3.50–11.00%, part lost on heating 950? or volatile matter 9.38–15.61 %, pure activated carbon of 76.94–79.16%, and absorption of iodine of 574.36–628.30 mg/g. The utilization of activated carbon derived from cocoa pod husks has demonstrated its efficacy in the adsorption of the heavy metal iron (Fe) present in well water. This adsorption process exhibits a notable absorption capacity within the range of 0.0967–0.0991 mg/g, accompanied by a high absorption efficiency ranging from 96.62% to 99.02%. The most effective activator, as determined by its iodine number, was found to be potassium hydroxide (KOH), which exhibited an impressive absorption capacity of 628.30 mg/g of iodine. On the other hand, magnesium chloride (MgCl2) emerged as the most economically viable activator, with a price of Rp. 30,00 per gram.
INNOVATION IN PROCESSING OF ARECA PEEL WASTE INTO ORGANIC POLYBAGS AS NURSERY MEDIA
Authors: Adinda Salwa Rahmasari  , Azzahra Oftan  , Yolanda Putri  , Ray Ferdinand  , Zaskhia Melani  , Hariance Rika
Published: October 2023

Polybags are planting media that are often used as nursery media. However, the use of polybags can cause the environment to become polluted due to the use of plastic, which is difficult to decompose by soil microbes, and also can destroy planting media and caused root damage in planting process to the field. One way to overcome these problems is to use organic-based nursery containers that are environmentally friendly. Poliarec (Polybag Organic of Areca catechu) is an organic polybag derived from areca peel waste. This product was made in 3 stages, first stages by making of polybags using 250 gr of areca peel waste to produce one unit of polybag measuring 10x10 cm. The second stage was carried out weight and density tests, and the third stage was carried out functional tests by conducting planting experiments on horticultural seeds. Poliarec can be planted directly on the ground because it is easily decomposed by microbes so that it can simultaneously become fertilizer and is able to maintain soil moisture. The density test showed, Poliarec has a low density category type based on SNI standards. It can function well as a seedling media after a functional test on chili seeds for 4 weeks. From this functional test, it was also found that Poliarec can save water usage because watering can be done once every three days. The direct benefits of this creative and innovative work are in addition to support sustainable agriculture by reducing the use of plastic polybags, and also will increasing the economic value of areca peel waste.
THE EFFICACY OF ISOPROPYL AMINE GLYPHOSATE 165 SL HERBICIDE EFFECT ON WEED CONTROL OF COCONUT CULTIVATION
Authors: Hariandi Doni , Setiawan Ryan Budi , Rizki Khairur
Published: October 2023

Coconut plants are an important commodity for Indonesian people. In the cultivation process, coconut plants need a suitable environment for growth and production. One of the problems in cultivation is weeds. Weeds have a negative impact on cultivated plants, therefore appropriate control measures are needed. So far, the most effective weed control is chemical methods using herbicides. One of the herbicides that can be used is the herbicide with isopropyl amine glyphosate 165 SL. The aim of the experiment was to determine the efficacy of the herbicide isopropyl amine glyphosate 165 SL for controlling weeds in coconut cultivation was conducted from February to June 2022 at Pariaman City, West Sumatra Province. The experimental units were laid out according to a Randomized Block Design with 7 treatments and 3 groups as replications. The treatment was herbicide isopropyl amine glyphosate 165 SL at doses of 3.50 l ha-1, 5.25 l ha-1, 7.00 l ha-1, 8.75 l ha-1, 10.00 l ha-1, manual weeding and control (without weeding). The results of the research show that (1) The herbicide isopropyl amine glyphosate 165 SL can generally control weeds in coconut cultivation up to 12 weeks after application because the weed biomass in the treatment plot is relatively the same as manual weeding and is lighter than the control; (2) Herbicide isopropyl amine glyphosate 165 SL with a dose range of 3.50 l/ha – 10.50 l ha-1 up to 6 weeks after application does not show symptoms of phytotoxicity in coconut plants.
Oral –Periodontal Findings of Langerhans Cell Histiocytosis (Case Report)
Authors: H Abdullah Bashar , Gh. Ali Basima , Rehan Ameena , Sh Musside Omar , Jawad Hanaa
Published: October 2023

Langerhans cell histiocytosis is a rare disease related to aggressive proliferation of histiocytes that could be a multisystem involvement disease. The diagnosis is based on the histopathological finding. Oral findings should carefully be considered when extensive periodontal involvement is seen in comparison to marginal periodontitis.
Prevalence of Oral Manifestation of Thalassemic Patients in Sulaymaniyah Thalassemia Center
Authors: Rahim Abdulkarim Dastan , M. Gaphor Shanaz
Published: October 2023

Thalassemia is a genetic blood disorder characterized by abnormal hemoglobin formation, leading to chronic anemia. The objective of this study was to evaluate orofacial complications in thalassemia patients and to detect the blood profile among these patients. Patients and method included a total of 100 th alassemic patients who were enrolled in this study. Oral examination and dental status of each patient was carried out using OHI-simplified. In addition, each patient took a blood investigation (Hb, RBC, MCV, RDW, and ferritin). Result of this study showed that the majority of the patients were female (68%) of which 50 of them had major Thalassemia, with the most frequent age range was between 21-39 years. Patients had statistically higher frequencies of all oral manifestations (p < 0.001 for all). Of which pale mucosa accounted for most frequency, 79%, followed by halitosis 39%, ulceration, brown pigmentation 33%, atrophic glossitis and actinic cheilitis 11%, hypomineralisation 8%, candidiasis and burning sensation 7%, geographic tongue and fissured tongue 6%, angular cheilitis 5%. Besides poor oral hygiene measure was 42%. Also, there was a significant positive correlation between most oral manifestations and blood transfusion. As a conclusion, thalassemia disease is associated with orofacial manifestation, which can adversely affect the oral health status of the patient. Therefore, dentists should understand the complications and management of the disease.
Salivary Biomarkers in Periodontal Diseases: A Review
Authors: Jasim Khalaf Salim , Salih Hamad Mahdi , Rifaat Sarhat Entedhar
Published: October 2023

Saliva represents an important biological material for diagnosis of oral problems. Salivary biomarkers like enzymes, proteins, or oxidative stress are used for early screening of oral diseases and evaluating of disease activity, and also measure the efficacy of therapy, therefore; it is used for determination of periodontal disease activity and prognosis. Salivary biomarkers are potentially important for determining the presence, risk, and progression of periodontal disease, therefore; it is not only reflecting the current status of periodontal diseases but may predict their progression and response to treatment. The prevalence of periodontitis is about 5–15% worldwide. There are some factors that may increase the incidenc e of periodontitis like smoking, obesity, diabetes, and heart diseases. Method of assessing and monitoring periodont al disease must be quick, easy and reliable and should provide important diagnostic information that improves and speeds treatment decisions.
The Effect of Microwave Irradiation and Some Denture Cleansers on The Bond Strength of Soft Liner to CAD/CAM-Milled Acrylic Resin
Authors: Kareem Rustam Hamzah , M. Al-Nema Luma
Published: October 2023

Disinfection of dentures and denture liners was desired for cross-contamination prevention and improved safety. Nonetheless, it has been discovered that these procedures impact the physical and mechanical features of denture liners.To assess the impact of different disinfection procedures on the tensile bond strength of an acrylic-based soft liner with CAD/CAM-based acrylic denture resin. Material and Methods: 25 specimens were collected and randomly divided into five groups (sodium hypochlorite, chlorohexidine, cleansing tablet, microwave, and control groups), following the daily disinfection protocol, the samples were stored at room temperature (23±2°C) in distilled water. After 30 days, the tensile bond strength was determined using universal testing equipment (Gester, China). The specimens were subjected to force by the machine at a steady crosshead speed of 5 mm/minute till the failure was recorded. The data were analyzed using statistics software (SPSS). Results: Showed that the control group had a higher mean value for bond strength, whereas the chlorhexidine group had a lower value. There was no significant difference between the control and cleansing tablet groups. However, they were significantly different from the microwave, CHX, and NaOCl groups. The NaOCl soft liner group is significantly different from all the other groups. No significant difference is found between microwave and CHX disinfected liner groups. Conclusion: The tensile bond strength of all disinfected soft liners decreased as compared with the control, which was not significant with the protefix tab but significant with the NaOCl, CHX, and microwave groups.
El mundo bajo la máscara: el vórtice creativo en Le Fantôme de l’Opera
Authors: García Izquierdo Diana Celeste
Published: October 2023

"The independent Irish animation studio Cartoon Saloon, one of the greatest examples of European animation, has created a series of films based on Celtic Irish mythology throughout their short but prosperous career. In their films they reflect the stories of fairies and druids intertwined with the reality of a country tormented throughout history. In this article we’ll analyse these myths, the sources they’re based on, and how the studio uses them and updates them to tell new stories based on the stories of yore."
Pathogenetic substantiation of combination therapy for rosacea
Authors: Kubanov Alexey A. , Plakhova Xenia I. , Kondrakhina Irina N. , Volkova Sofia V.
Published: October 2023

Rosacea is a chronic inflammatory dermatosis predominantly damage to the skin of the face, which has a significant negative impact on the quality patients’ lives. The main goal of treatment is to achieve the most complete remission. However, due to the fact that the pathogenesis of the disease is not fully understood, the search for new methods of treatment is especially relevant. Combined use pulsed dye laser and ivermectin drug is presented as alternative pathogenetically substantiated method of therapy. The purpose of the study is to characterize immune disorders and the role of cytokines in the pathogenesis of rosacea, as well as the possibilities of combination therapy based on literature data. An analysis of literature sources from the MedLine, Pubmed, eLibrary databases for the period from 2002 to 2022 was carried out, using the keywords “ivermectin”, “pulsed dye laser”, “rosacea”, “cytokines”, “ivermectin” , “Pulsed Dye Laser”, “rosacea”, “cytokines”.
Evaluation of a Newly Formulated Anti-Inflammatory Ointment from Ficus religiosa Root Bark
Authors: G Jyothisree , Umadevi S.
Published: October 2023

The basis of the medical system is medicinal herbs. Herbal combinations for therapeutic alignment often include botanical components. This work aims to make an anti-inflammatory ointment from the Ficus religiosa root bark and test the medicine using a novel HPTLC technique. The flavonoid component from the hydroalcoholic extract was separated by column chromatography. The mobile phase used was a mixture of toluene, ethyl acetate, and methanol in the ratio 04:04:02. By using the fusion method to create a straightforward ointment from this separation, it was discovered that the formulation’s physicochemical properties were all within acceptable bounds. The mobile phase for the HPTLC study included toluene, ethyl acetate, formic acid, and methanol (3:3:0.8:0.2), and the wavelength was 280 nm. Using albino mice and the Carrageenan-induced paw edema method, the anti-inflammatory effect was assessed. Rf value is discovered to be 0.86, 0.88, and 0.89 for simple ointment, fractionate, and standard quercetin, respectively. According to ICH criteria, the HPTLC method was validated, and all parameters were within acceptable ranges. The created ointment can be used in a straightforward manner to alleviate inflammation. In comparison to NSAIDS, the topical formulation showed good anti-inflammatory action in carrageenan-induced paw edema.
Formulation and Evaluation of Moxifloxacin Dry Powder Inhaler Combined with Mucolytic Agent for Pulmonary Diseases
Authors: M.P Ratnaparkhi , O.V Kamble , S.S Salvankar , S.R Shinde , G.M Kulkarni , A.B Shewale , D.D Kadam , A.J Shaikh
Published: October 2023

The DPI is the device that administers the drug through the dry powder to the lungs. People with Multi-drug resistant tuberculosis or other lung diseases frequently use such devices to take their prescribed medicines. Numerous approaches have been used to formulate dry powder inhalation formulation and enhance the delivery performance of dry powder inhaler preparation. In the case of multi-drug resistance tuberculosis, a high dose of combination therapy was delivered, resulting in resistance to the anti-TB medications in the majority of patients. Moxifloxacin and levofloxacin are being used to minimize the need for a high-dose treatment regimen. This study aimed to achieve local lung administration of tumor-targeting Moxifloxacin, by administering microspheres that can be inhaled as a dry powder inhaler for targeting Phagocytes of alveoli via pulmonary passage. Spray drying had been used to formulate MXN-DPI formulations, afterward optimized with the 23-factorial design model. Two different amounts of lactose, leucine, and medication were used to make the eight batches. The developed formulation was studied for physicochemical properties like morphology and particle size. The particle dimensions of the MXN-DPI compositions have been confirmed to be in the range of 1.4 to 4.1 μm. The prepared formulations effectively showed drug release up to 93% in 5 hours, which was observed through in-vitro diffusion studies.
Fexofenadine Hydrochloride Dispersible Tablets: A Taste Masking Strategy using Ion Exchange Resin
Authors: Barge Kajal , Tank Shivali , Parab Bhagyashri , Nagarsenkar Mangal , Shidhaye Supriya
Published: October 2023

The pediatric population is more sensitive to allergies. Fexofenadine hydrochloride (FXD-HCL), a non-sedative antihistaminic drug, was chosen to create taste-masked patient-compliant pediatric dispersible tablets. Due to its bitter taste, fexofenadine hydrochloride is unsuitable for the formulation of dispersible tablets; therefore, Kyron T-134®, cation exchange resin was used to form a taste-masked complex with the drug to overcome its bitterness. The FXD HCL-resin complex was prepared using a kneading method and the complexation was confirmed by differential scanning calorimetry and FTIR studies. The FXD HCL-resin complex was evaluated for flow properties, degree of bitterness, assay and release study. Dispersible tablets were formulated by using a co-processed excipient, Granfiller-D211® containing croscarmellose sodium and crosspovidone, microcrystalline cellulose and mannitol. 22 factorial designs with two replicates optimized the dispersible tablets. The tablets, prepared using the direct compression technique on a single-stroke tablet compression machine, were elegant in appearance. Various pre and post-compression tests were conducted on all formulations. The tablets of hardness 3.5 kg/cm2 showed friability, disintegration time, assay within the compendial limit and showed immediate release of a drug (NLT 60% in 10 min and NLT 80% in 30 minutes) in 0.001 N HCl (pH 3). The DSC thermogram indicated partial amorphization of the FXD HCL. Dispersible tablets of fexofenadine hydrochloride and Granfiller-D®211 at 1:4 proportion was stable for one month at ambient and accelerated storage conditions.
Computational Exploration of Anti-Alzheimer Potential of Flavonoids against Inducible Nitric Oxide Synthetase: An In-silico Molecular Docking and ADMET Analysis Approach
Authors: Nemade Mahesh , Patil Khushabu , Bedse Anjali , Chandra Piyush , Ranjan Rakesh , Tare Harshal , Patil Samir
Published: October 2023

Alzheimer’s disease (AD) is a formidable challenge in neurodegenerative disorders, marked by relentless cognitive decline, memory impairment, and a pervasive neuroinflammatory milieu. Recent scientific inquiries have unveiled a compelling link between the rampant overexpression of inducible nitric oxide synthetase (iNOS) and the intricate pathogenesis of AD. Within this context, flavonoids, a diverse class of polyphenolic compounds widely distributed in fruits & vegetables, have garnered substantial interest due to their recognized antioxidant and anti-inflammatory attributes. This research endeavor harnessed the power of cutting edge in-silico molecular docking techniques to embark on a compelling exploration. Specifically, we aimed to unravel the therapeutic potential of various flavonoids as putative inhibitors of iNOS, with the ultimate objective of combatting the insidious progression of AD. Our investigative odyssey unveiled promising outcomes. Molecular docking simulations illuminated the binding interactions between diverse flavonoids and the iNOS enzyme, offering insights into their potential inhibitory prowess. Among these flavonoids, a notable contender emerged, denoted as CHEMBL490697, which exhibited a remarkable negative binding affinity of -8.3 kcal/mol, demonstrating its strong attraction to the targeted protein. Furthermore, CHEMBL490697, admirably traversed the rigorous terrain of drug likeness parameters, underscoring its potential as a viable therapeutic candidate. In summation, this comprehensive investigation has illuminated the potential of CHEMBL490697 as a promising therapeutic agent with drug like properties, exemplified by its robust, stable, and tight binding to the iNOS enzyme. These findings present a compelling avenue for further research and development in the pursuit of best managements for AD.
Preparation and Evaluation of Primidone Solid Lipid Nanoparticle for Alleviating Seizure Activity in Wistar Rats
Authors: Agarwal Pooja , Vasudha B.
Published: October 2023

Introduction: In order to increase primidone’s anticonvulsant action, the study set out to manufacture it in solid lipid nanoparticle form (PRI-SLN). Method: Microemulsification and ultrasonication procedures were used to create 17 PRI-SLN formulations. Results: The PRI-SLN displayed a high entrapment efficiency (46.37 ± 2.42% to 81.82 ± 1.21%), as well as small particle size (149.9 ± 6.72 to 188.8 ± 5.25 nm). According to the in-vitro release study, PRI from SLNs releases more slowly than PRI by itself. The thermal analysis showed the drug’s compatibility with other substances and its presence in the more soluble amorphous state. Following a lethal and chronic dosage of picrotoxin, the PRI-SLN exhibited a higher anticonvulsant efficacy, according to in-vivo research on rats (p< 0.05). Conclusion: SLN with stronger anticonvulsant action can be made from PRI.
Evaluation of Lipid Profile and Sexual Hormones in Women with Polycystic Ovarian Syndrome at Al-Najaf Province
Authors: Hassan Abdul-Samad U , K Ameer N.
Published: October 2023

Background: A multiple-factorial condition influencing females’ reproductive years is polycystic ovarian syndrome (PCOS). This study aims to investigate lipid profiles and sex hormones, and DHEA hormones related to patients suffering from PCOS. Method: In this investigation, the sex hormones, lipid profile and DHEA hormone of 45 females in their reproductive years who were suffering from PCOS were compared to those of 45 women who were healthy and of a similar age. Results: Our results showed that the mean ± standard deviation of triglyceride parameter is higher than others parameters in both women patients with polycystic syndrome (73.2 ± 147.3 mg/dl) and control (57.9 ± 123.7 mg/dl) groups with highly significant difference (p-value < 0.001). While, mean ± standard deviation of other parameters, including cholesterol, HDL, LDL and VLDL, was higher in women with polycystic syndrome than in the control groupe. Conclusion: The more active fertile age group, 21 to 30 years old are more susceptible to the incidence of PCOS. Our data shows a significant correlation between DHEA and cholesterol, HDL, VLDL in the patient group. There is a positive statistical correlation between DHEA and LDL and between DHEA and LH, prolactin, and testosterone. The correlation between DHEA and FSH showed a passive association (statistically significant).
Phenol Glucosides as Potential Inhibitors of SGLT1 for Enhanced Diabetes Mellitus Treatment in Patients with Declining Renal Function
Authors: Nemade Mahesh , Patil Khushabu , Bedse Anjali , Chandra Piyush , Ranjan Rakesh , Tare Harshal , Bhise Manish
Published: October 2023

Diabetes mellitus poses a significant global health challenge, necessitating the continual search for innovative therapeutic strategies. While sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown promise in diabetes management, their efficacy diminishes in patients with declining renal function. This study aims to evaluate the potential of phenol glucosides as inhibitors for the sodium-glucose transport protein 1 (SGLT1), a key player in glucose uptake. We identified phlorizin as a representative phenol glucoside for experimental validation. The SGLT1 protein structure (PDB ID 7wmv) was analyzed through Ramachandran plot, ERRAT score, and ProSAweb Z-score, confirming its high-quality 3D conformation. A ligand-based virtual screening approach yielded 400 compounds that matched well with our pharmacophore models, including 10 compounds from virtual libraries. Notably, two compounds stood out for their high matching scores. Molecular docking simulations revealed strong binding affinities with SGLT1, especially for the compound CHEMBL2303983 with a binding energy of -11.2 kcal/mol. ADMET analysis was conducted to evaluate the drug-likeness & safety profile of such high-affinity compounds. The compounds exhibited variable water solubility and moderate lipophilicity but were generally compliant with most drug-likeness rules. However, certain challenges such as low GI absorption and inability to cross the blood-brain barrier were identified. No PAINS or Brenk alerts were raised, suggesting a low likelihood of assay interference or toxicity. In conclusion, our in-silico approach has identified promising candidates among phenol glucosides for inhibition of SGLT1, albeit with challenges in solubility and pharmacokinetics that require further optimization. The study opens new avenues for the synthesis and experimental verification of novel SGLT1 inhibitors.
One Pot Synthesis of 1-(phenyl)-1H Indoles, their Biological Screening and ADME Studies
Authors: Thaker Tirth , Panchani Dipen , Bhuva Vaishal
Published: October 2023

This research aims to develop a novel way for synthesizing indole derivatives. 1-(phenyl)-1H-indole analogues were synthesized by cyclization of 1-phenyl-2-(phenyl amino)-ethane-1-one. Biological evaluation of title compounds and absorption, distribution, metabolism and excretion (ADME) studies were performed and title compounds had a higher affinity and created ample interactions with different proteins.
Synergistic Effect of L-cycloserine and Capecitabine on Human Colon Cancer Cell Line
Authors: Sahib Zena H , Almedeny Seher A. R
Published: October 2023

Introduction: Colon cancer comes in second place in the list of cancers in developed countries. Drug resistance is one of the causes of colorectal cancer therapeutic failure that usually occurs in most patients in advanced stage of colon cancer. This study investigates the effect of adding L-cycloserine to capecitabine in the HCT-116 colon cancer cell line. Materials and methods: We compared the combined L-cycloserine-capecitabine effect with each of the two drugs alone on the HCT-116 colon cancer cell line as a positive control group. The growth rate inhibition was examined by crystal violet assay. Results: The growth inhibition effect of L-cycloserine-capecitabine, L-cycloserine and capecitabine on HCT-116 cells was assessed with crystal violet assay, different concentrations including 3.12, 6.25, 12.5, 25, 50, and 100 μg/mL were used for L-cycloserine-capecitabine combination, and for both L-cycloserine and capecitabine. After incubation for 24 hours, results appeared that the combination of L-cycloserine and capecitabine increased the effect of both drugs alone as seen by a significant increase (p <0.05) of the growth inhibition percentages in the L-cycloserine-capecitabine combination as compared with the positive control groups. Conclusion: From the result, we can conclude that the L-cycloserine combination with capecitabine has a synergistic effect for colon cancer treatment that could be a more effective regimen.
Synthesis and Molecular Docking Studies of New Pyrimidinone ring Containing 1,2,3-Triazole Derivatives
Authors: Kozan Ahmed A , Nahi Riyadh J
Published: October 2023

The current work describes the design, synthesis and molecular mocking studies of a series of new 1,4-disubstituted-1,2,3-triazole linked 2-pyrimidinone derivatives. Firstly, 4-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)benzene sulfonic acid 1 was synthesized as a key starting material. This compound was reacted with a series of aromatic aldehydes under-investigated conditions to give a new series of chalcones 2a-f. Reaction of compounds 2a-f with urea in the presence of an aqueous solution of sodium hydroxide led to the construct 2-pyrimidinone ring system to obtain a series of new compounds containing 1,2,3-triaozle ring and pyrimidinone ring 3a-f. The newly synthesized compounds 2a-f and 3a-f were characterized by FT-IR, 1H-NMR and 13C-NMR spectra. In-silico molecular docking simulations, compounds 3a-f and their precursors 2a-f were conducted on two selected proteins: 7dpp and 8cx9. The results revealed that all of the newly synthesized compounds 2a-f and 3a-f displayed have a good binding affinity with the target proteins and higher than values recorded for the selected three standard antiviral drugs.