bluuebunny/crossref_metadata_2025 huggingface dataset:
ИССЛЕДОВАНИЕ ЗАМИРАНИЙ В СИСТЕМЕ СВЯЗИ С ИСПОЛЬЗОВАНИЕМ ТЕХНОЛОГИИ OFDM
Authors: Бреславец Алексей Андреевич , Тоцкий Александр Владимирович
Published: October 2018

A new technique exploited for estimating of fading influence in multipath signal propagation environment for communication system using OFDM (Orthogonal frequency-division multiplexing) technology is proposed. Rayleigh fading model is considered and studied in suggested approach. Wi-Fi network has been selected as a basis system for study performance of OFDM communication system operating in multipath and noisy communication channel. Preliminary experimental measurements and computations have been carried out in order to evaluate received signal parameters after test signal propagation through multipath communication link contaminating transmitted signal under influence of random Rayleigh fading. An algorithm has been developed that makes it possible to perform computations according considered model. Software corresponding to suggested algorithm has been developed. Proposed software contains user interface that is written in order to automate the process of computations. Developed software was examined experimentally for statistical study of interference behavior and its influence on the OFDM communication system performance. The following data were taking into account in investigations: Rayleigh fading; user's motion; number of operating OFDM subcarriers; number of receiving antennas; additive normal noise. The influence of these factors on the communication system performance was evaluated by computation the value of bit error rate (BER) values. Suggested software also gives an opportunity investigating the number of bit errors and appearance of the signal in the time and frequency domains at different stages of transmission. Computer simulations results were obtained for a sequence of test Monte Carlo runs depending on: the speed and angle of the user's traffic; the intensity of the additive Gaussian noise in communication channel; variations of the number of OFDM subcarriers; the number of antennas contained in the user equipment. Computer simulation results demonstrate the following: bit error rate values tend to increasing with increasing the user velocity as well with decreasing the number of antennas and subcarriers. It has been also shown decreasing the signal-to-noise ratio value under influence of additive noise with a Gaussian distribution according to decreasing the number of OFDM subcarriers and number of antennas in MIMO system.
СТРАТЕГИЯ 3WIN УСТОЙЧИВОЙ КООПЕРАЦИИ ИТ-ИНДУСТРИИ И УНИВЕРСИТЕТОВ: R&D СТАРТ-АП ШКОЛЫ
Authors: Лобачев Михаил Викторович , Антощук Светлана Григорьевна , Харченко Вячеслав Сергеевич
Published: October 2018

A 3Win strategy for establishing a sustainable model of collaboration between the industry and universities is developed. Primary objectives of the work are outlined and are focused on the establishment of a model of sustainable collaboration between the industry, academic and research societies and student teams. This allows us to resolve the issue of preparing well qualified IT specialists in the necessary fields in collaboration with foreign partners and teams. This also presents the opportunity of development and research, targeted at the end consumer, by creating working prototypes or products. The sustainability of such a collaboration model supplements and is maintained by the long-term integration of mutual interests of the parties participating in the process. The analysis of the viability of this model is carried out on the basis of operation of R&D Start-up School. The definition of the 3Win strategy is established, as an interaction model, based on which each of the participating parties (the university, the company and the student body) receives their own personal benefits and achieves their own goals. In addition, this is a synergic model – where the cooperation of the participants results in a much more effective outcome, than individual efforts of each of the participants separately. The model, which is described as the 3Win strategy, in a way can be classified as a synthetic model, that incorporates the benefits of a number of other models developed previously. A1 – a department within the university as an incubator for developers, A2 – a department within the university as a center for certification support, Model B – a department within the university acting as a center for collaborative research and development and finally Model C – a department within the university as a business incubator. Simultaneously, this is a new class within the models of higher calibre, due to the fact that it facilitates a high degree of stability for the collaboration. The implementation of the model within the scope of international multi-university collaboration is described, along with its benefits. Examples of interaction between various components of the models based on existing cases are provided and the approaches for the 3Win strategy between the industry, universities and student body are described. The road-maps for further development of the aforementioned approaches are established
МОДЕЛЬ І АЛГОРИТМ НАВЧАННЯ ДЕТЕКТОРА ШКІДЛИВОГО ТРАФІКУ НА ОСНОВІ МОДИФІКАЦІЇ ЗРОСТАЮЧОГО НЕЙРОННОГО ГАЗУ
Authors: Москаленко В’ячеслав Васильович , Москаленко Альона Сергіївна , Зарецький Микола Олександрович
Published: October 2018

It is proposed the model of the hierarchical convolutional extractor of malware traffic features. Image with resolution 28x28 pixels and 10-th channels formed on the basis of successive 10 network packet flows is considered as model input. It allows to describe the spatial-temporal statistical characteristics of the traffic. The feature extractor consists of two convolutional layers with three-dimensional filters, sub-sampling layers, and activation calculation layers based on the orthogonal matching pursuit algorithm and the ReLU function. It is proposed the model of decision rules of the malware traffic detector based on information-extreme classifier. It allows to receive computatially simple decision rules and evaluate the informational efficiency of the feature extractor in the condition of the limited volume of the relevant labeled training dataset. The classifier performs an adaptive feature discretization and construction of the optimal in the information sense of radial-basis containers of classes in binary Hamming space. An information criterion of learning efficiency is the modification of S. Kulbak's measure as a function of the frequency of errors of the first and second type. Growing neural gas algorithm for pretraining of the feature extractor is improved by modifying the mechanism of insertion and updating of neurons. It allows utilizing unlabeled training samples and obtaining the optimal distribution of neurons to cover the training sample. Modification of the mechanism of insertion of new neurons is to form a new neuron at the reach of the threshold, and not with a given frequency. It allows you to improve the stability of the learning process and regulate the generalization ability of the model. The modification of the mechanism for updating the weighting coefficients of the neurons is to use the of Oja's rule instead of the Hebb's rule, which allows to avoid uncontrolled growth of neuron weights and adapts convolutional filters for sparse coding of input observation. It is proposed meta-heuristic search algorithm of simulated annealing for the training of decision rules and fine-tuning high-level filters of feature extractor. Simulation results using CTU-Mixed and CTU-13 datasets confirm the effectiveness of the resulting decision rules for recognizing the malware traffic from test samples
ПРИМЕНЕНИЕ ДЕРЕВЬЕВ АТАК ДЛЯ ОЦЕНИВАНИЯ ВЕРОЯТНОСТИ УСПЕШНОЙ АТАКИ WEB-ПРИЛОЖЕНИЯ
Authors: Тецкий Артём Григорьевич
Published: October 2018

The development of technologies leads to the expansion of the range of services provided on the Internet, the online business is actively developing. As a rule, when creating a new Web resource for business, the main emphasis is on the need to stand out among the sites of competitors. Often, the owners of Web resources understood the possible consequences of cyber-incident only after when their resource was attacked. This paper discusses the frequent causes of attacks of Web-applications created with the content management systems. A content management system allows to create sites without directly writing code. The main sources of information about frequent security problems of Web-resources are documents of organizations OWASP, SANS, Positive Technologies. Due to the high activity of intruders, it is necessary to create methods for assessing the security of the Web-application and methods for countering attacks. In the paper, the need to assess the probability of a successful attack of Web-applications is conditioned. In practice, it is impossible to determine all possible attack scenarios, because each Web-application has its own functionality. The frequent attack scenarios on which the tree was built are investigated. The method of estimating the probabilities of basic events using expert assessments based on the results of the preliminary implementation of a set of measures to identify the security problems is used. The developed method of assessing security allows to consider not only possible vulnerabilities in the source code, but also possible security policy violations. The proposed method can be applied by business entities working in the field of information security, when choosing security measures for a particular Web-application. A further direction of research is the development of a method for choosing countermeasures based on the described method. The method should demonstrate the effect of each countermeasure on the probability of a successful attack
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI EKSPOR KOMODITAS TEH INDONESIA
Authors: Sidabalok Supriani
Published: October 2018

Penelitian ini bertujuan untuk: (1) untuk menganalisis bagaimana pengaruh hargaekspor teh Indonesia di luar negeri terhadap volume ekspor teh Indonesia, (2) untukmenganalisis bagaimana pengaruh nilai tukar rupiah terhadap dolar AS terhadapvolume ekspor teh Indonesia, (3) untuk menganalisis bagaimana pengaruh pendapatannegara pengimpor teh terbesar terhadap volume ekspor teh Indonesia, dan (4) untukmenganalisis bagaimanapengaruh harga kopi sebagai barang substitusi dari tehterhadap volume ekspor teh Indonesia.Data yang digunakan adalah time series daritahun 2002 sampai 2013 dan data cross section dari 5 negara pengimpor teh Indonesiayaitu Rusia, Pakistan, Malaysia, Jerman, dan AS. Metode analisis yang digunakanadalah model regresi Ordinary Least Square-Pooled Data dengan bantuan softwareEviews versi 6.0. Hasil regresi menunjukkan bahwa variabel nilai tukar (EX), hargaekspor teh (PL), pendapatan nasional negara pengimpor (PDB), dan harga kopi (PC)secara bersama-sama mampu menjelaskan variasi atau perubahan variabel volumeekspor teh Indonesia sebesar 86,36% sedangkan sisanya 13,64% dijelaskan oleh variabellain yang tidak dimasukkan dalam model estimasi.
LEXICAL CHANGE CAUSES OF JAVANESE LANGUAGE IN DELI SERDANG REGENCY.
Authors: Sutikno Wariyati,
Published: October 2018

This qualitative research addresses the lexical change in Javanese language, which is aimed at  explaining the lexical change reasons of Javanese language in Deli Serdang Regency. The transmigration process as the main aspects of creating Javanese language changes into variety accent and invite more action for the revitalization of language. The empirical materials were thoroughly and well-gathered from the document and interview. The highly critical and systematic analysis with ‘Miles and Huberman Model’ reveals that Javanese language in Deli Serdang Regency changes. This research has drawn the following reasons of lexical changes of Javanese language in Deli Serdang Regency were linguistic causes, historical, environmental causes and psychological causes. The internal reasons are homonym (words which have the same phonemic structure but different meanings), phonetic attrition (the variations of meanings due to the sound change), and shortening. On the other hand, external factors are historical or social. Nevertheless, the social factor of lexical change pointed out is about cultural factor due to the wide definition of social factor itself, which might be cultural, historical, economic,ect. In addition, the reasons of language changes for language split and language borrowing are recognizable on this phenomenon since the Javanese language of Deli Serdang Regency has diversity in classifying of dialect.
MODEL PEMBELAJARAN PROBLEM POSING UNTUK MENGATASI KESULITAN BELAJAR MAHASISWA BERBAHASA INGGRIS BIDANG EKONOMI DALAM MEMPERSIAPKAN ENTEPRENUER HANDAL
Authors: Afningsih Nila
Published: October 2018

In general, students still have difficulty to convey ideas, thoughts, questions and so on in the language, especially in English. The students have to prepare themselves before going directly to the job market. One of the efforts that can be used as an alternative problem solving is to apply Problem Posing Model based on contextual.This research is also an effort to overcome the difficulties of students in English in order to prepare themselves as a reliable entrepreneurs needed by the world economy of this country or even the international world. This research was conducted on Economics Faculty student UMN Al-Washliyah Medan.After doing this research, we got positive results from the students. Students have more confidence in English as their capital to prepare a reliable entrepreneur. This research does not stop until it is only because of the results of this research will be published in the form of journal articles, proceedings, and textbooks that can be used by students, especially English Business subjects.
TRADISI MEMASUKI RUMAH BARU PADA SUKU JAWA DI KOTA MEDAN
Authors: Rosmawati Harahap Siti Nur Khodijah,
Published: October 2018

Masalah penelitian ini adalah apakah masyarakat Jawadi Kota Medan masih melakukan acara tradisi memasuki rumah baru? Tujuan penelitia peneliti inginmendeskripsikan beberapa orang bersuku Jawa di Kota Medan masih melakukan acara tradisi memasuki rumah baru. Metode penelitian ini adalah metode kualitatif deskriptif. Sumber datanya adalah teks informasi tentang perilaku acara tradisi memasuki rumah baru di daerah Jalan Panglima Denai dan Kecamatan Medan Tembung.  Instrumen penelitiannya adalah observasi dan wawancara. Data  utama  penelitian ini  didapatkan melalui wawancara mendalam yang dilakukan peneliti pada kurun waktu bulan Juli  sehingga bukan September 2018. Peneliti wawancarai  beberapa orang pemilik rumah baru yang bersuku Jawa di Kota Medan. Lokasi penelitian ini yaitu Medan Denai, dan Medan Tembung. Pelaku acara tradisi memasuki rumah baru bersuku Jawa  di Jalan Panglima Denai dan Medan Tembung telah terjadi perlakuan tradisi memasuki rumah baru yang disertai ritual berdoa yang sesuai ajaran Islam yaitu doa keselamat, minta rezeki, bahagia, nyaman, aman, dan tenteram, empati bagi orang lain kelak di hari nanti .Biasanya masyarakat suku Jawa dari rumah lamanya akan berbondong-bondong mengantarkan orang tersebut dalam melakukan pindah rumah barunya. Adat ini pun masih berlangsung sampai sekarang digunakan pada masyarakat suku Jawa. Sebagian masyarakat pada suku Jawa masih ada yang percaya mengenai   adat istiadat memasuki rumah baru mengenai bacaan-bacaan dan ada ebagian masyarakat yang hanya ikut-ikutan saja dan tidak tahu pada maksud dari makna tradisi memasuki rumah baru itu.
Analysis of Hacker Attack Using Honeypot High Interaction
Authors: Sari Wahyu Purnama , Adhi Palguna Putra I Nyoman
Published: October 2018

Information is a corporate asset that should be kept confidential access to parties who are not responsible. Aspects of the security of the information to be protected includes the Confidentiality, Integrity and Availability. A wide range of attacks and threats can be made to take over the assets of the desired information. A hacker is someone who has the ability to penetrate security systems of a company. There are several types of hacker attacks performed, i.e. SQL Injection, Cross Site Scripting (XSS), Brute Force, Distributed-Denial-of-Service (DDoS), Inclusion, Code Injection and more. Honeypot is a security technology that aims to identify, find security gaps and contribute actively when there are security intrusions on information technology activities. High Interaction Honeypot (Hihat) may record and collect information more specific attacks and more. The type of attack that was recorded by the Honeypot Hihat is then analyzed to find out the type of attack that most got into XYZ Company.
Reduction of COD and TSS of waste effluents from a sugar industry through the use of air micro-nanobubbles
Authors: Leyva Milagros , Valverde Flores Jhonny
Published: October 2018

The sugar industry uses large volumes of water for its production process. The discharge of effluents is one of the main problems that affects mainly rivers, seas, resulting in the high level of pollution that captures plant and aquatic life. The objective of this research is to reduce the concentration of Chemical Oxygen Demand and Total Suspended Solids by treating air nanobubbles. The experiment was carried out with a sample of sugar process effluent having as the initial concentration value of the Chemical Oxygen Demand of 412.15 mg O2/L. and Total Suspended Solids of 620 mg TSS/L. After treating the water in a time of 90 minutes it was obtained as final result the Chemical Oxygen Demand was 66.13 mg O2 /L and Total Suspended Solids 131 mg TSS/L, improving water quality as well as for reuse for another type of use.
Pelaksanaan Metode Active Learning dalam Meningkatkan Hasil Belajar Siswa pada Pembelajaran Pendidikan Agama Islam
Authors: Toha Sukron Muhammad
Published: October 2018

Rendahnya kualitas pembelajaran merupakan salah satu permasalahan yang dihadapi dunia pendidikan sekarang ini, seperti pembelajaran Pendidikan Agama Islam (PAI). Pada Proses pembelajaran pendidikan agama yang terjadi biasanya bersifat seadanya, formalitas, rutinitas, dan kurang bermakna. Dalam upaya meningkatkan kualitas pembelajaran pendidikan agama adalah dengan memperbaiki kualitas pembelajaran, yaitu melalui Metode Active learning. rumusan masalah penelitian ini adalah apakah pelaksanaan metode active learning dalam pembelajaran agama Islam dapat meningkatkan pemahaman siswa SDIT Al Hikmah dan serta faktor pendukung dan penghambat dalam pelaksanakan metode active learning pada siswa SDIT Al Hikmah. Penelitian ini deskripsi pelaksanaan metode active learning untuk meningkatkan pemahaman siswa pada pembelajaran agama Islam SDIT Al Hikmah serta untuk mendeskripsikan faktor pendukung dan penghambat penerapan metode active learning di dalam meningkatkan pemahaman siswa pada pembelajaran agama Islam SDIT Al Hikmah. Penelitian ini bersifat field research (penelitian lapangan) dengan sumber data dari siswa, guru PAI, wakil kepala sekolah, kepala sekolah dan pelaksanaan metode active learning dalam meningkatkan pemahaman siswa serta dokumen di SDIT Al Hikmah. Metode pengumpulan data yang digunakan adalah observasi, interview, dan dokumentasi. Sedangkan metode analisis data yang digunakan adalah deduktif. Hasil penelitian ini menunjukan bahwa pelaksanaan metode active learning mempengaruhi dalam peningkatkan pemahaman siswa kelas SDIT Al Hikmah, sehingga siswa aktif dalam kelas dan dapat memahami pendidikan agama Islam dengan metode yang menarik dan tidak membosankan. Hal tersebut ditandai dengan naiknya nilai siswa secara cukup signifikan. faktor pendukung dan penghambat dalam pelaksanaan metode active learning yaitu diskusi kelompok.
El recurso extraordinario. La cuestionada innovación del proyecto de ley del nuevo Código Procesal Civil chileno
Authors: Avendaño Leyton Ignacio Alejandro
Published: October 2018

El recurso extraordinario. La cuestionada innovación del proyecto de ley del nuevo Código Procesal Civil chileno
Aproximación crítica entre las jurisdicciones del civil law y del common law y la necesidad de respeto a los precedentes
Authors: Marinoni Luiz Guilherme
Published: October 2018

Aproximación crítica entre las jurisdicciones del civil law y del common law y la necesidad de respeto a los precedentes
A recomendação da União Européia, de 11 de junho de 2013, sobre as ações coletivas
Authors: Gonçalves de Castro Mendes Aluisio , Pochmann da Silva Larissa Clare
Published: October 2018

A recomendação da União Européia, de 11 de junho de 2013, sobre as ações coletivas
LA INFORMACIÓN PROVENIENTE DE LAS REDES SOCIALES COMO MEDIO TECNOLÓGICO DE PRUEBA
Authors: Mercado (ponente) SEMILLERO Lidia Karina
Published: October 2018

LA INFORMACIÓN PROVENIENTE DE LAS REDES SOCIALES COMO MEDIO TECNOLÓGICO DE PRUEBA
El principio de legalidad formal bajo el prisma de la Constitución “normatizada”
Authors: Berizonce Roberto Omar
Published: October 2018

El principio de legalidad formal bajo el prisma de la Constitución “normatizada”
La dimensión constitucional del principio de contradicción y sus reflejos en el derecho probatorio brasileño
Authors: Guimarães Ribeiro Darci
Published: October 2018

La dimensión constitucional del principio de contradicción y sus reflejos en el derecho probatorio brasileño
The Queer Body of MLF Literature
Authors: Berger Anne Emmanuelle
Published: October 2018

The emphasis on sexuality from a queer perspective has led to what is deemed to be a radical rethinking, and what is oftentimes also a reinventing, of sexuality's medium or element, namely the body. Looking back at literary writings produced in the 1970s by some of the women engaged in the French Women's Liberation Movement, and more specifically at the ways in which the body and bodies were at once celebrated, figured and dismantled in a number of these texts, I argue that a proto-queer de-normativization and reconceptualization of the body with respect to ‘sex’ and sexual duality was already at work. A serious look back at the writings of that period makes the hypothesis of an epistemological break between second-wave feminism and queer thinking and activism, or of the conceptual supersession of the former by the latter, more difficult to argue in this respect.
‘Wittig and Davis, Woolf and Solanas (…) simmer within me’: Reading Feminist Archives in the Queer Writing of Paul B. Preciado
Authors: Evans Elliot
Published: October 2018

This article considers the relation between contemporary queer and transgender theory and the ‘second wave’ of feminism. Specifically, it explores the ways in which transgender theorist Paul B. Preciado's Testo Junkie: Sex, Drugs, and Biopolitics (2008) calls on feminist theorists, artists and activists of the second wave to explore transgender experience and embodiment, and to rethink gender in light of the new era of biocapitalism Preciado proposes. The article questions the way in which trajectories of feminism are conceived of (most famously through the ‘waves’ metaphor), and finally calls for a ‘scavenger methodology’ as a way to consider the formation of feminist and queer archives.
Magnetic and luminescent coordination networks based on imidazolium salts and lanthanides for sensitive ratiometric thermometry
Authors: Farger Pierre , Leuvrey Cédric , Gallart Mathieu , Gilliot Pierre , Rogez Guillaume , Rocha João , Ananias Duarte , Rabu Pierre , Delahaye Emilie
Published: October 2018

The synthesis and characterization of six new lanthanide networks [Ln(L)(ox)(H2O)] with Ln = Eu3+, Gd3+, Tb3+, Dy3+, Ho3+ and Yb3+ is reported. They were synthesized by solvo-ionothermal reaction of lanthanide nitrate Ln(NO3)3·xH2O with the 1,3-bis(carboxymethyl)imidazolium [HL] ligand and oxalic acid (H2ox) in a water/ethanol solution. The crystal structure of these compounds has been solved on single crystals and the magnetic and luminescent properties have been investigated relying on intrinsic properties of the lanthanide ions. The synthetic strategy has been extended to mixed lanthanide networks leading to four isostructural networks of formula [Tb1−xEux(L)(ox)(H2O)] with x = 0.01, 0.03, 0.05 and 0.10. These materials were assessed as luminescent ratiometric thermometers based on the emission intensities of ligand, Tb3+ and Eu3+. The best sensitivities were obtained using the ratio between the emission intensities of Eu3+ (5D0→7F2 transition) and of the ligand as the thermometric parameter. [Tb0.97Eu0.03(L)(ox)(H2O)] was found to be one of the best thermometers among lanthanide-bearing coordination polymers and metal-organic frameworks, operative in the physiological range with a maximum sensitivity of 1.38%·K−1 at 340 K.
Photocatalyic Appel reaction enabled by copper-based complexes in continuous flow
Authors: Minozzi Clémentine , Grenier-Petel Jean-Christophe , Parisien-Collette Shawn , Collins Shawn K
Published: October 2018

A copper-based photocatalyst, Cu(tmp)(BINAP)BF4, was found to be active in a photoredox Appel-type conversion of alcohols to bromides. The catalyst was identified from a screening of 50 complexes and promoted the transformation of primary and secondary alcohols to their corresponding bromides and carboxylic acids to their anhydrides. The protocol was also amendable and optimized under continuous flow conditions.
Differential Extracellular, but Similar Intracellular, Disposition of two Tenofovir Formulations in the Male Genital Tract
Authors: Dumond Julie B , Greene Stephen A , Prince Heather , Chen Jingxian , Maas Brian M , Sykes Craig , Schauer Amanda P , Blake Kimberly H , Nelson Julie AE , Gay Cynthia L , Kashuba Angela DM , Cohen Myron S
Published: October 2018

Background

The male genital tract (MGT) is a viral sanctuary and likely HIV reservoir; understanding MGT pharmacokinetics (PK) of antiretrovirals (ARVs) used for curative strategies is critical to eradication and cure. Tenofovir alafenamide (TAF) is a tenofovir (TFV) formulation designed to maximize efficacy/minimize toxicity with unknown MGT PK.

Methods

HIV-positive and HIV-negative men receiving TFV-based regimens provided six paired blood plasma (BP) and semen samples. Extracellular (TFV, TAF, emtricitabine [FTC]) drug concentrations in BP and seminal plasma (SP), and intracellular metabolite (IM) and endogenous nucleotide (EN) concentrations were measured in peripheral blood mononuclear cells (PBMCs) and seminal mononuclear cells (SMCs). Exposure ratios for SP:BP, SMC:PBMC and IM:EN were calculated from PK parameters generated by noncompartmental analysis. HIV viral load was measured in BP and SP.

Results

Sixteen HIV-positive ( n=8, TDF/FTC; n=8, TAF/FTC) and eight HIV-negative (TDF/FTC) men provided samples. Median TFV SP:BP ratios differed between TDF and TAF (1.5 versus 7.4), due to lower TFV BP concentrations with TAF coupled with TFV SP concentrations similar to TDF. FTC SP:BP ratios were approximately 3. SMC concentrations of IMs and ENs were a fraction of PBMC concentrations (1–22%), though IM:EN ratios exceed a suggested protective threshold.

Conclusions

TAF SP PK was unexpected. IM SMC concentrations were low relative to PBMC, as were EN concentrations, suggesting differences in cell phenotype and lineage in the MGT; these differences in phenotype and pharmacology may have an impact on selecting and dosing ARVs used in cure strategies.
Survey of molecular determinants in Gram-positive cocci isolated from hospital settings in Argentina
Authors: Jeric Paola E. , Azpiroz Agustina , Lopardo H. , Centrón D.
Published: October 2018

Background: In order to study the resistance mechanisms to aminoglycosides, tetracyclines and erythromycin, we investigated the genetic determinants on 85 Streptococcus spp., Staphylococcus spp., and Enterococcus spp. isolates collected from 46 hospitals of Argentina over a two-year period.
Methodology: The MICs to amikacin, gentamicin, kanamycin, and streptomycin, tetracycline and erythromycin were determined by the standard broth dilution method according to CLSI recommendations. Detection of resistance genes to the antibiotic tested was assessed by the PCR standard technique whereas the clonal relationships of each species was performed by PFGE.
Results: Major heterogeneity was detected in aminoglycoside and erythromycin resistances. Indeed, 37.6% of the isolates harbored the aac(6’)-aph(2’’) genes; 27% harbored the aph(3’)-IIIa and ant(6)-Ia genes along with the aac(6’)-aph(2’’) gene; 7% carried the ant(4')-Ia gene; and 71% harbored one or more of the erm(A), erm(B), erm(TR), mef(A), mef(E) and msr(A) genes. The tetracycline resistance was determined by the tet(M) gene and was found in 23 isolates that were resistant to this antibiotic. Spreading of tet(M) by the Tn916-like transposon was not a frequent event since the integrase of this element was detected only in 3 Streptococcus spp. isolates. Instead, a 370 bp fragment was detected that corresponded to a region of the CW459-like element integrase in 10 of 11 methicillin-resistant Staphylococcus aureus and in 3 group G Streptococcus isolates, a finding that implies a novel mechanism for tetracycline resistance spreading.
Conclusion: This study demonstrates the wide spreading of resistance mechanisms in our nosocomial cocci population and underscores the importance of continuous and efficient epidemiological surveillance.
Successful treatment of multidrug resistant Acinetobacter baumannii meningitis
Authors: Saçar Suzan , Turgut H. , Hırçın Cenger D. , Coskun E. , Asan A. , Kaleli I.
Published: October 2018

Background: Acinetobacter baumannii is a major cause of nosocomial infections in many hospitals and appears to have a propensity for developing multiple antimicrobial resistance rapidly. Cases: We report two cases with post-surgical meningitis due to multidrug resistant A. baumannii which were successfully treated with high-dose intravenous meropenem therapy. Conclusions: Multidrug resistant Acinetobacter spp. in intensive care units are a growing concern. High-dose meropenem is used in the treatment of these infections.
Les Songes de la nef, pour une « prise de site » musicale et sonore
Authors: Bonardi Alain
Published: October 2018

Dans cet article, nous développons le concept de « prise de site » au niveau musical en dialogue avec Jean-Louis Déotte et ses écrits, dans le cadre de notre installation sonore Les Songes de la nef (2018) pour l’Hôtel-Dieu de Tonnerre, double hommage au philosophe et au compositeur Jean-Claude Risset. À l’opposé de l’accrochage dans un musée, la « prise de site » permet de penser l’accueil d’œuvres contemporaines dans des lieux patrimoniaux comme relation dynamique entre les deux, comme une « critique » au sens du commentaire à distance entre musiques que propose le compositeur Luciano Berio. Nous avons pensé l’installation sonore Les Songes de la nef avant tout comme un instrument à construire, nous référant au compositeur Helmut Lachenmann. Nous montrons que l’installation doit être considérée comme un cadre posant un certain nombre de relations, d’abord acoustiques avec le lieu l’accueillant ; mais aussi permettant la découverte par le visiteur itinérant de relations entre le contenu sonore et l’Hôtel-Dieu, et donc une nouvelle appréhension de cet édifice patrimonial.
Idée esthétique : prise de site
Authors: Déotte Jean-Louis
Published: October 2018

Comment un artefact (un édifice architectural ici) devient-il un objet du patrimoine ou, plus exactement, un objet de patrimoine vivant ? L’article avance la notion de prise de site (à distinguer des œuvres in situ), couplée à celles d’idée esthétique et d’analogie, pour penser un rapport à l’œuvre qui ne soit pas soumis aux valeurs de nouveauté.
Do dental calculi predict the presence of renal stones?
Authors: Kati Bulent , Kalkan Ergin , Pelit Eyyup Sabri , Yagmur Ismail , Çiftçi Halil
Published: October 2018

Objective: Pathological calcifications that occur in various parts of the body may cause stone formation over time. The structure of these stones is similar in many regions of the body. We have studied the relationship between dental calculi and kidney stones. Material and methods: A total of 183 patients with dental stone complaints or dental calculi were included between April and August 2016 in the Cagri Dental Hospital, Elazig, Turkey. Patients were evaluated with regard to a urinary tract ultrasonography, urinalysis, oral hygiene, and stone and surgical disease history. All information was statistically investigated. Results: The age of the patients in the kidney stones group was significantly higher than the non-kidney stone patients (p < 0.05). In the group with kidney stones, the percentage of dental calculus formation was significantly higher than the group without stones (p < 0.05). In the groups with and without kidney stones, dental stone recurrence rates did not differ significantly (p < 0.05). Urinary pH was significantly lower in the group with stones than the group without stones (p < 0.05). Conclusions: During a physical examination, the formation of a visible stone, such as a dental calculus, may be an indicator of other types of stones, such as kidney stones, and this should be further investigated.
Serenoa repens extracts: In vitro study of the 5α-reductase activity in a co-culture model for Benign Prostatic Hyperplasia
Authors: Buonocore Daniela , Verri Manuela , Cattaneo Laura , Arnica Sara , Ghitti Michele , Dossena Maurizia
Published: October 2018

Objectives. Benign Prostatic Hyperplasia (BPH) is a form of benign tumor that occurs in humans mainly with ageing. It affects more than 50% of over 50 years old males and it is characterized by an increased synthesis of dihydrotestosterone (DHT), due to the 5α-reductase activity. The BPH therapeutic approach mainly uses 5α-reductase inhibitors, such as the active compounds present in the extracts deriving from species Serenoa repens. Many lipidosterolic extracts are available on the market, which are obtained with different solvents, among them ethanol is recognized as non-toxic and has less handling risks than hexane. The purpose of the present experimental study was to investigate in-vitro the potency of an ethanol extract of S. repens comparing it with an n-hexane one. Materials and methods. Two different lipido-sterolic extracts of S. repens have been tested: ethanol extract and n-hexane extract, two batches for each one. The inhibitory action of the extract was evaluated estimating in-vitro the activity of enzyme 5α-reductase type I (5α-RI), which was mainly active under the experimental condition of pH 7.5. DHT amount, synthesized from testosterone (1 μM), was evaluated in a co-culture model of epithelial cells and fibroblasts resulting from prostatic biopsy of a patient with BPH.Results. The analysis of the resulting dose-response curves showed that the entire S. repens extracts inhibited the 5α-RI showing no difference between the two kinds of extract or between the batches. The resulting IC50 values were the following: 8.809 (95% CI = 5.133-15.56) and 9.464 (95% CI = 5.094- 18.27) for ethanol extracts; 11.08 (95% CI = 6.389-19.98) and 12.72 (95% CI = 7.758-21.53) for n-hexane extracts. Conclusions. The potency of ethanol extracts of S. repens was comparable with the one of n-hexane extracts.
Hibiscus extract, vegetable proteases and Commiphora myrrha are useful to prevent symptomatic UTI episode in patients affected by recurrent uncomplicated urinary tract infections
Authors: Cai Tommaso , Tiscione Daniele , Cocci Andrea , Puglisi Marco , Cito Gianmartin , Malossini Gianni , Palmieri Alessandro
Published: October 2018

Objective: To evaluate the efficacy of a combination of Hibiscus extract, vegetable proteases and Commiphora myrrha extract in the prophylaxis of symptomatic episode in women affected by recurrent urinary tract infections (rUTIs). Materials and methods: In this phase II clinical trial, all patients with history and diagnosis of rUTI were enrolled. All patients underwent the following treatment schedule: 1 tablet in the morning and 1 tablet in the evening for 7 days and, then, 1 tablet in the evening for 10 days (1 cycle every each month, for 6 months) of a combination of Hibiscus extract, vegetable proteases and Commiphora myrrha extract. At the baseline, all patients underwent urologic visit with quality of life (QoL) questionnaires and mid-stream urine culture. After 3 and 6 months, all patients underwent urologic visit, urine culture and QoL questionnaires evaluation. Results: Fifty-five women were enrolled (mean age 49.3; range: 28-61). At the enrollment time, the most common pathogen was Escherichia coli (63.7%). The median number of UTI per 6 months was 5 (IQR: 4-9). At the end of the second follow-up evaluation, 25 women did not reported any symptomatic episode of UTI (49%), 18 reported less than 2 episodes (35.3%), while 8 reported more than 2 episodes (15.7%). However, at the first and second follow-up evaluation the clinical statistically significant improvement (QoL) was reported by 38/51 (74.5%) (p < 0.001 from baseline) and 43/51 (84.3%) (p < 0.001 from baseline) women, respectively. The median number of UTI decreased to 2 (IQR: 0-3). At the end of the follow-up period, 30/51 had sterile urine (58.8%), while 21/51 (41.2%) reported a transition from symptomatic UTI to asymptomatic bacteriuria. Conclusions: In conclusion, this treatment, in motivated patients, is able to prevent symptomatic UTI symptomatic episode and improve patient’s QoL.
Adolescence and andrologist: An imperfect couple
Authors: Olana Soraya , Mazzilli Rossella , Delfino Michele , Zamponi Virginia , Iorio Cristina , Mazzilli Fernando
Published: October 2018

Objective: The aims of this research were to study: a) the prevalence of male adolescents, aged between 10 and 19 years of age, referred to our Unit for an andrological assessment; b) the reasons (stated and subsequently modified) for referral; c) the prevalence of clinically diagnosed diseases.Materials and methods: A total of 2.855 subjects, referred to the Andrology Unit for a first examination, were retrospectively studied. For each adolescent, a medical history was taken and an andrological physical examination was carried out. Results: Prevalence was found to be 6.9% (197/2855). Subjects were divided into two groups according to age (A: ≤ 14 and B: ≥ 15 years). The original reason stated for their consultation was corrected by 11.7% of the subjects (23/197); this correction concerned almost all the Group B subjects (21/23 (91.3%) vs 2/23 (8.7%) of Group A; p < 0.01). Regarding sexual dysfunctions, a simple explanation of certain conditions reassured the subject in about 15% of the cases. Furthermore, the physical examination proved extremely useful, revealing clinical alterations in more than 60% of subjects. Conclusions: In conclusion, to date in Italy, the prevalence of adolescents among males referred to an Andrology Unit for assessment is very low. It is important to encourage adolescents to undergo andrological examination to enable identification of reproductive function and psycho-sexual disorders.
Malignant mesothelioma of tunica vaginalis testis: Report of a very rare case with review of the literature
Authors: Trenti Emanuela , Palermo Salvatore Mario , D'Elia Carolina , Comploj Evi , Pycha Alexander , Carella Rodolfo , Pycha Armin
Published: October 2018

Introduction: Mesothelioma of the tunica vaginalis testis is a extremely rare tumor and represents 0.3 to 0.5% of all malignant mesotheliomas. Exposure to asbestos often precedes illness. Because of its low incidence and nonspecific clinical presentation, it is mostly diagnosed accidentally during surgery for other reasons and the prognosis is usually poor. We present a case of a patient with a mesothelioma of tunica vaginalis testis, diagnosed secondarily during hydrocele surgery, with long-term survival after radical surgery. Materials and methods: a 40 years old patient was admitted to our department for routine surgery of a left hydrocele. During the operation a frozen section analysis was requested because of the unusual nodular thickening of the tunica vaginalis: the examination revealed a diffuse malignant mesothelioma with epithelioid structure and tubular-papillary proliferation. Therefore a left hemi-scrotectomy with left inguinal lymph node dissection was performed. Results: The definitive histology confirmed the previous report of diffuse malignant mesothelioma with angio-invasion but normal testicle findings and negative lymph nodes. No metastases were found on the CT-scan. For the first 2 years a CT was repeated every 4 months, for other 3 years every 6 months and then yearly. Six years after surgery the patient is classified as no evidence of disease. Conclusions: malignant mesothelioma of the tunica vaginalis testis is a rare entity, often initially thought to be a hydrocele or an epididymal cyst. An aggressive approach with hemiscrotectomy with or without inguinal and retroperitoneal lymphadenectomy can reduce the risk of recurrence.
THE JAK2V617F POINT MUTATION INCREASES THE OSTEOCLAST FORMING ABILITY OF MONOCYTES IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS AND MAKES THEIR OSTEOCLASTS MORE SUSCEPTIBLE TO JAK2 INHIBITION
Authors: Spanoudakis Emmanouil , Papoutselis Menelaos , Bazntiara Ioanna , Lamprianidou Eleftheria , Kordella Xrisa , Tilkeridis Constantinos , Tsatalas Constantinos , Kotsianidis Ioannis
Published: October 2018

JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and four age-matched normal donors (ND). Osteoclast forming assays started from selected monocytes also and under titrated concentrations of the JAK2 Inhibitor AG-490 (Tyrphostin). Genomic DNA was extracted from the formed osteoclasts, and the JAK2V617F/JAK2WT genomic DNA ratio was calculated. OCLs formed from monocytes derived from heterozygous (Het) for the JAK2V617F mutation MPN patients, were three times more compared to those from JAK2 wild type (WT) MPN patients (p=0,05) and from ND as well (p=0,03). The ratio of JAK2V617F/JAK2WT genomic DNA was increased in OCLs compared to the input monocyte cells showing a survival advantage of the mutated clone. In comparison to ND and JAK2 WT MPN patients, OCLs from patients JAK2V617F (Het) were more susceptible to JAK2 inhibition. These alterations in osteoclast homeostasis, attributed to mutated JAK2, can deregulate the hemopoietic stem cell niche in MPN patients.
Incidence of Sport-Related Internal Organ Injuries Due to Direct-Contact Mechanisms Among High School and Collegiate Athletes Across 3 National Surveillance Systems
Authors: Kucera Kristen L. , Currie Dustin W. , Wasserman Erin B. , Kerr Zachary Y. , Thomas Leah Cox , Paul Stephen , Comstock R. Dawn
Published: October 2018

Context

Although sport-related internal organ injuries among athletes are relatively infrequent, combining data sources enables a more comprehensive examination of their incidence.

Objective

To describe the incidence and characteristics of sport-related internal organ injuries due to direct-contact mechanisms among high school (HS) and collegiate athletes from 2005–2006 through 2014–2015.

Design

Descriptive epidemiology study.

Setting

United States HS and collegiate sports data from 3 national sports injury-surveillance systems: High School Reporting Information Online (HS RIO), the National Collegiate Athletic Association Injury Surveillance Program (ISP), and the National Center for Catastrophic Sport Injury Research.

Patients or Other Participants

High school and collegiate athletes in organized sports.

Main Outcome Measure(s)

Characteristics of the athlete, event, and injury were examined and stratified by data source and sport. Descriptive statistics of internal organ injuries via direct-contact mechanisms consisted of frequencies and incidence rates (IRs) per 1 000 000 athlete-exposures and 95% confidence intervals (CIs).

Results

During the 10-year period, 174 internal organ injuries were captured: 124 in HS RIO and 41 in the ISP; 9 were catastrophic. Most noncatastrophic injuries occurred among males (RIO = 85%, ISP = 89%), in football (RIO = 65%, ISP = 58%), and during competitions (RIO = 67%, ISP = 49%) and were due to player-player contact (RIO = 78%, ISP = 68%). The highest injury rates were in male contact sports: RIO football (IR = 11.7; 95% CI = 9.1, 14.2) and lacrosse (IR = 10.0; 95% CI = 3.1, 16.9); ISP: football (IR = 8.3; 95% CI = 5.0, 11.6) and ice hockey (IR = 7.9; 95% CI = 1.0, 14.7). A quarter of noncatastrophic injuries were season ending (RIO = 25%, ISP = 23%). Of the 9 catastrophic injuries, most occurred in HS (7/9) and football (7/9) and were due to player-player contact (6/9). Four resulted in death.

Conclusions

Direct-contact internal organ injuries occur infrequently; yet when they do occur, they may result in severe outcomes. These findings suggest that early recognition and a better understanding of the activities associated with the event and use or nonuse of protective equipment are needed.
A 9-Year Epidemiologic Study (2007–2015) on Race-Day Jockey Fall and Injury Incidence in Amateur Irish Horse Racing
Authors: O'Connor Siobhán , Warrington Giles , MB Adrian McGoldrick , Cullen SarahJane
Published: October 2018

Context

Point-to-point racing may place jockeys at risk of serious injuries due to the high incidence of falls as previously reported. Despite many advances in health and safety strategies, the incidence of falls and injuries in point-to-point racing has not been reported since 2006.

Objectives

To provide a longitudinal analysis of the fall and injury incidence in point-to-point horse racing jockeys in Ireland from 2007 to 2015 and compare these findings with the previous literature.

Design

Descriptive epidemiologic study.

Setting

All injuries that occurred due to a fall at every official point-to-point race meeting from 2007 to 2015 were recorded by a medical doctor using a standardized injury report form.

Main Outcome Measure(s)

Falls and injury rates and their 95% confidence intervals were calculated. Incidence rate ratios (IRRs), 95% confidence intervals and percentage change were compared between point-to-point and professional racing, between previous data and the current results, and from 2007 to 2015.

Results

An average of 67.40 injuries/1000 falls and 9.08 injuries/1000 rides occurred in point-to-point racing, and this was reduced compared with the previous analysis. Amateur jockeys sustained an overall mean of 134.77 falls/1000 rides and the yearly means decreased over the 9 years of the study. Amateur jockeys sustained a higher fall rate than professional jockeys (flat: IRR = 35.47 [31.03, 40.54]; jump: IRR = 2.72 [2.63, 2.82]); however, their injuries/1000 falls rate was lower (flat: IRR = 0.19 [0.15, 0.24]; jump: IRR = 0.33 [0.30, 0.63]). Soft tissue injuries were predominant (43.09%), with 26.06 fractures and 9.98 concussions/1000 falls occurring.

Conclusions

Although injuries have been reduced since the previous analysis, more serious injuries such as fractures and concussions were more common in point-to-point racing than professional racing, possibly due to their higher fall risk. Thus, identifying strategies to reduce the fall risk in point-to-point racing should be a priority.
Egbreuk
Authors: Van der Westhuizen H.G.
Published: October 2018

No abstract available.
Die opskrifte van die profeteboeke I
Authors: Oberholzer J.P.
Published: October 2018

No abstract available.
Calvins sozialethik und der Kapitalismus
Authors: Esser Hans Helmut
Published: October 2018

No abstract available.
Wat is die kerk?
Authors: Dreyer Joh
Published: October 2018

No abstract available.