bluuebunny/crossref_metadata_2025 huggingface dataset:
YABANCI PORTFÖY YATIRIMLARI, BORSA VE MAKROEKONOMİK DEĞİŞKENLER ARASI İLİŞKİLERİN VAR YÖNTEMİYLE ANALİZİ: TÜRKİYE ÖRNEĞİ
Authors: Şenol Zekai , Koç Selahattin
Published: February 2018

Gelişmekte olan
ekonomiler için yabancı sermaye yatırımlarının çok önemli olduğu bilinen bir
konudur. Ülkelere sağlanan sermaye akımlarının ülkelerin kalkınması, cari
açıklarının azalması, yatırımlarının artırılması ve buna bağlı olarak
istihdamlarının azaltılması gibi konularda pozitif katkılarının olduğu
görülmektedir. Bu çalışmanın amacı, yabancı portföy yatırımı girişi ile borsa
ve makro ekonomik faktörler arasındaki ilişkinin analiz edilmesidir. Bu
çalışmada, 2006:Q1 – 2016:Q4 yıllarını kapsayan çeyrek dönemlik veriler ile  Otoregresif model (VAR) kullanılmıştır. Bu
çalışmada elde edilen sonuçlara göre, yabancı portföy yatırımlarından (DYPYG);
Borsa İstanbul (DBIST), faiz oranı (DFAIZ) ve döviz kuruna (DKUR) doğru tepkiler
görülmüştür. Diğer taraftan döviz kurundan da (DKUR) yabancı portföy yatırımlarına
(DYPYG) yönelik tepkinin varlığı tespit edilmiştir. Varyans ayrıştırmasında
ise, yabancı portföy yatırımlarında meydana gelen değişimlerin döviz kuru,
borsa ve faiz oranı tarafından açıklandığı belirlenmiştir.
Evaluation of open versus closed pilonidal sinus excision in Basrah, Iraq
Authors: Muhsen Ahmed A. , Ali Alaa H. , Alharoon Mahmood S.
Published: February 2018

Background: Pilonidal sinus is a disease that most commonly arises in the hair follicles of the natal cleft of the sacrococcygeal area. Different modalities of surgery have been employed. The aim of this study is to evaluate the outcome of open versus closed pilonidal sinus excision among a sample of patient in Basrah of Iraq.Methods: This is a prospective study conducted in two hospitals. The patients were randomly allocated into 2 groups. Group “A” consisted of 63 patients who underwent open pilonidal sinus excision and the other group (group “B”) included 68 patients who underwent closed pilonidal sinus excision. Technically, both approaches were performed according to the "standard procedure". All patients, in both groups, were seen on the 3rd, 7th and 10th days following surgery. Afterwards, they were followed up at weekly intervals until complete healing took place and three-monthly after that, for 2 years, to check for recurrence.Results: One hundred and thirty-one patients include in this study, 63 patients comprised group “A” open pilonidal sinus excision (54 males and 9 females) compared to 68 patients in group “B” closed pilonidal sinus excision (56 males and 12 females). The rate of wound infection approximately was similar (3.17% in group “A” and 2.94% in group “B”) two patients in both groups.Conclusions: This study shows significant difference in patient duration needed to retain normal life activity between open and closed method. Closed method achieved shorter duration of recovery.
Indigenous Women as the Other: An Analysis of the Missing Women's Commission of Inquiry
Authors: Beniuk Jodi
Published: February 2018

In this paper, I discuss the ways in which Indigenous women are Othered by the proceedings of the Missing Women‘s Commission of Inquiry (MWCI). First, I give a basic overview of Beauvoir‘s theory of women as Others, followed by Memmi‘s analysis of the relationship between the colonized and the colonizer. I use these two theories to describe the way Indigenous women are Othered both as Indigenous peoples and as women, focusing on the context of the twenty-six who were murdered in Vancouver‘s Downtown Eastside (DTES). The original murders were the result of the cultural reduction of Indigenous Women to their bodies. The negligent police investigations, as well as the misogynistic attitudes of the police, also demonstrate how Othering can operate within these institutions. I claim that the violence against women in the DTES was due to their status as Other. Notably, the MWCI, which is supposed to be a process that addresses the Othering-based negligence of the police, also includes instances of Othering in its structure and practice. From this, I conclude that we cannot rely on Othering institutions or legal processes to correct Othering as a practice. In the context of the MWCI, I suggest building alliances that support those who face this Othering as violence in their everyday lives.
RELIGIUSITAS DENGAN FLOW AKADEMIK PADA SISWA
Authors: Alfarabi Arbi , Saraswati Putri , Dayakisni Tri
Published: February 2018

Problems in education are students who experience boredom in the learning process, whereas in the learning required concentration, interest and motivation, which required students to experience flow. Flow itself blends in total concentration which refers to the solemn concept in religiosity. The purpose of this research is to know religiosity relationship with academic flow. The design of this study is non-experimental correlation type. The data retrieval technique uses cluster sampling technique. Totals subjects as many as 222 students in city of Malang. Data collection method used in this research is the scale of religiosity made by the researcher. Then the scale of academic flow using the scale of LIS (The flow inventory for student), the researchers add some items in the scale of LIS. Data analysis method used product moment. The results of data analysis obtained r = 0.508 p = 0.000 (sig <0.01) means that this study shows a significant positive relationship between religiosity and academic flow. While the effective contribution of religiosity to academic flow is 25.8% and the rest equal to 74.2%, influenced by other factors.
Triceps Tendon Repair
Authors: Conti Mica Megan , van Riet Roger
Published: February 2018

Although triceps tendon ruptures can result from a traumatic incident, chronic overuse causing degenerative changes to the insertion and leading to a complete or partial rupture is more common. In our practice, we have found that anabolic steroid abuse by weightlifters is the most common predisposing factor. The initial diagnosis is often missed. A thorough clinical examination is imperative to avoid missing a partial or complete rupture. Ultrasound or magnetic resonance imaging can confirm the diagnosis. Early diagnosis increases the chance of a direct repair. Operative treatment with direct repair is usually indicated for full-thickness or large partial-thickness tears. Direct repair may be possible for selected chronic tears. Triceps tendon repair is performed with the following steps.

Step 1: The patient is placed in lateral decubitus.

Step 2: The stump is debrided, and retraction of the tendon is evaluated.

Step 3: Two crossed bone tunnels are drilled, and an anchor is placed centrally in the olecranon.

Step 4: The elbow is extended, and the tendon is reduced and sutured centrally to the anchor and medially and laterally with use of the sutures from the bone tunnels.

Step 5: The elbow is flexed to evaluate tension. If gapping occurs, the repair should be reinforced with extra sutures. Tension-free range of motion will guide postoperative rehabilitation.

Step 6: A posterior splint is applied in the operating room with the elbow extended.

Step 7: A dynamic brace is applied on the first postoperative day. Extension is free but flexion is blocked at the tension-free range; 30° of extra flexion is permitted every 2 weeks. Full flexion is always allowed after 6 weeks. Strengthening starts at 3 months.

Pitfalls of the procedure include difficulty in differentiating between tendon and scar in subacute and chronic ruptures. It may not be possible to directly repair the triceps back to bone, and a graft may be needed to reconstruct the tendon. It is important to know where the ulnar nerve is and to release it if needed. It is important not to debride past the cortical surface of the olecranon if an anchor is used because, if this is done, fixation may be insufficient. The anchor should be predrilled as the cortical bone of the tip of the olecranon is very dense.

Reruptures occur in up to 21% of cases. A functional range of motion is usually achieved with an average loss of extension of 10° and average flexion to 136°. At 1 year, one can expect a peak strength of approximately 80% of that on the uninjured side and endurance strength of 99%
1
.
The Teaching of Psychology in Colombia: The Challenges for the Discipline and High Quality
Authors: Cornejo Ochoa William
Published: February 2018

Editorial
Age May Be the Only Variable Effecting Microhematuria Prevalance in Pelvic Organ Prolapse
Authors: Gokmen Karasu Ayse Filiz , Aydin Serdar , Adanir Ilknur , Ilhan Gulsah , Kalkan Senad , Ates Seda
Published: February 2018

Objective: We aimed to estimate the prevalence of microscopic hematuria in women with pelvic organ descent and compare the results in terms of severity and accompanying urinary symptoms. We hypothesized that microhematuria incidence would be higher in advanced prolapse and accompanying urinary symptoms.Study Design: Women who presented to our clinic from January 2013 to July 2016 were analyzed using our electronic medical record system. Those who were classified in the system under the "N81: female genital prolapse" code were included. Records were checked to certify that samples were acquired properly. Urogynecological examinations were performed by specialist gynecologists and documented according to the international continence society classification system. After ruling out urinary tract infections urinalysis was performed by an integrated system composed of an urine strip analyzer and a sediment autoanalyzer.Results: Gravidity, parity, menopause onset, smoking status and presence of systemic disease were similar for both groups. Women in the hematuria group were older (p<0.001). Hematuria prevalance was greater ininternational continence society Stage 3-4 anterior prolapse and total prolapse (p=0.03) compared to early stage prolapse. However after logistic regression analysis; age was the only factor left in association with hematuria.Conclusions: Women who were older and with advanced stage prolapse ( ≥ international continence society stage 3) were more likely to have microscopic hematuria. Urine tests are requested routinely in the work-up of urogynecological patients. As the prevalance is microhematuria is high in this population; we believe that evidence based algorithms should be set as guidelines when hematuria is encountered in patients with organ prolapse.
Impact of a severe rain event on C- and N-DBP precursor removal using IEX
Authors: Doederer K. , Ilieva Z. , Keller J.
Published: February 2018

During disinfection, dissolved organic matter (DOM) is the major precursor to form disinfection by-products (DBPs), which may be of potential human health concern. Previous research focused on waters of continental climates and less on subtropical environments. However, water sources in subtropical climates are regularly impacted by major rain events during the summer months. This study evaluated the C- and N-DBP precursor removal capacity of two conventional ion exchange (IEX) resins and one magnetic ion exchange (MIEX) resin with a raw water at normal conditions and impacted by a heavy rain event. The rain event introduced 3 mg C/L total organic carbon (TOC) comprised mainly of low to medium molecular weight organics. All three resins were able to remove TOC and DBP precursors (>66%) but being less efficient in reducing turbidity (3–48%) and colour (9–24%). The resin with the smallest bead size was affected the most by the increased medium MW DOM loading resulting in DOM and C-DBP precursor removal performance losses of 10% and 22%. When applied as a pre-treatment for coagulation, MIEX was more efficient in DBP precursor control than coagulation in addressing the additional organic and DBP precursor loading after a heavy rain event.
On the sensitivity of geospatial low impact development locations to the centralized sewer network
Authors: Zischg Jonatan , Zeisl Peter , Winkler Daniel , Rauch Wolfgang , Sitzenfrei Robert
Published: February 2018

In the future, infrastructure systems will have to become smarter, more sustainable, and more resilient requiring new methods of urban infrastructure design. In the field of urban drainage, green infrastructure is a promising design concept with proven benefits to runoff reduction, stormwater retention, pollution removal, and/or the creation of attractive living spaces. Such ‘near-nature’ concepts are usually distributed over the catchment area in small scale units. In many cases, these above-ground structures interact with the existing underground pipe infrastructure, resulting in hybrid solutions. In this work, we investigate the effect of different placement strategies for low impact development (LID) structures on hydraulic network performance of existing drainage networks. Based on a sensitivity analysis, geo-referenced maps are created which identify the most effective LID positions within the city framework (e.g. to improve network resilience). The methodology is applied to a case study to test the effectiveness of the approach and compare different placement strategies. The results show that with a simple targeted LID placement strategy, the flood performance is improved by an additional 34% as compared to a random placement strategy. The developed map is easy to communicate and can be rapidly applied by decision makers when deciding on stormwater policies.
Eriugeny ontologiczna koncepcja rzeczywistości
Authors: Grzegorzyca Adam
Published: February 2018

W 2009 roku Benedykt XVI podczas audiencji generalnej zaproponował krótkie rozważanie dotyczące myśli Jana Szkota Eriugeny, którego poglądy zostały czterokrotnie potępione. Filozofia Eriugeny bywała w historii najczęściej ujmowana jako sprzeczna z chrześcijaństwem panteistyczna wizja rzeczywistości lub patrystyka i chrześcijański neoplatonizm. Artykuł jest próbą ukazania ontologicznej wizji rzeczywistości, którą Eriugena zaproponował w ramach autorskiego systemu filozoficznego. Zgodnie z wynikami rozważań nad zaproponowanym przez filozofa podziałem rzeczywistości na byt i niebyt oraz przyjętym kryterium podziału, artykuł stanowi również próbę analizy, czym ten podział skutkuje dla takich kategorii, jak Bóg, przyczyny rzeczy, człowiek, rzeczy zmysłowe i materia. Poglądy Eriugeny przeniknęły do europejskiej filozofii i w sposób ukryty oddziaływały, choć nie zostały w pełni docenione, a sam filozof nie został właściwie zrozumiany.
Metanaukowy kontekst problemu „brakującego ogniwa”
Authors: Wagner Michał Jakub
Published: February 2018

W pracy tej podejmowane jest zagadnienie form przejściowych ewolucji biologicznej w jej najbardziej znanej formie, czyli problemu „brakującego ogniwa”. Problem ten często pojawiający się w rozważaniach wczesnych darwinistów, został całkowicie zarzucony przez współczesnych ewolucjonistów. Zniknięcie kwestii brakującego ogniwa z zainteresowań współczesnej biologii tłumaczy się tym, iż poszukiwane formy przejściowe zostały już odnalezione. Sam zaś problem uważa się za nieistotny, gdyż spowodowany niekorzystnym wpływem różnych czynników pozanaukowych. Celem pracy jest wskazanie przyczyn, które doprowadziły do zmiany sposobu postrzegania owej problematyki. Szczególna uwaga zostanie poświęcona relacji taksonomii do sposobu, w jaki postrzegano poszukiwane brakujące ogniwa. Cały zaś problem brakującego ogniwa, jego przyczyny i zniknięcia, jest interpretowany jako wynik przemian metanaukowych, jakie zaszły w trakcie rozwoju taksonomii.
The Modification and Design of Antimicrobial Peptide
Authors: Gao Yidan , Fang Hengtong , Fang Lu , Liu Dawei , Liu Jinsong , Su Menghan , Fang Zhi , Ren Wenzhi , Jiao Huping
Published: February 2018

The antimicrobial peptides (AMPs) are a group of unique naturally occurring anti-microbial compounds
with around 50 amino acids. It represents promising therapeutic agents to the infectious disease without
concerning about drug resistance. However, commercial development of these peptides for even the simplest
application has been hindered by the limitations of sources, instability, toxicity and bioavailability. To improve
the properties of the artificial synthesized AMPs, the modification and design are the hotspots of the AMPs research.
In fact, more than half of the known AMPs are naturally modified. In this review, two types of modification
strategies, biochemical modification and chemical modification were summarized. Although, the chemical
modification is versatile and direct, the manufacturing cost is greatly increased compared to the antibiotics. With
the recent progress of the protein modification enzyme, the biochemical modification of the antimicrobial peptide
followed by heterologous expression has great application prospects.
Antimicrobial Synthetic Polymers: An Update on Structure-Activity Relationships
Authors: Ergene Cansu , Palermo Edmund F.
Published: February 2018

The rising incidence of antibiotic-resistant infections, combined with a declining number of new antibiotic
drug approvals, has generated an alarming therapeutic gap that critically undermines public health. Host
Defense Peptides (HDPs), sometimes referred to as “Nature’s Antibiotics”, are short chain, amphiphilic and cationic
peptide sequences found in all multicellular organisms as part of their innate immunity. While there is a vast
diversity in terms of HDP sequence and secondary structure, they all seem to share physiochemical characteristics
that can be appropriated for macromolecular design by the synthetic polymer chemist. Over the past decade,
remarkable progress has been made in the design and synthesis of polymer-based materials that effectively mimic
HDP action – broad-spectrum antibacterial potency, rapid bactericidal kinetics, and minimal toxicity to human
cells – while offering the additional benefits of low cost, high scalability, and lower propensity to induce resistance,
relative to their peptide-based counterparts. A broad range of different macromolecular structures and
architectures have been explored in this design space, including polynorbornenes, poly(meth)acrylates,
poly(meth)acrylamides, nylon-2 polymers, and polycarbonates, to name a just few. Across all of these diverse
chemical categories, the key determinants of antibacterial and hemolytic activity are the same as in HDPs: net
cationic charge at neutral pH, well-balanced facial amphiphilicity, and the molecular weight of the compounds. In
this review, we focus in particular on recent progress in the polymethacrylate category first pioneered by Kuroda
and DeGrado and later modified, expanded upon and rigorously optimized by Kuroda’s and many other groups.
Key findings and future challenges will be highlighted.
QSAR Analysis for Antioxidant Activity of Dipicolinic Acid Derivatives
Authors: Rastija Vesna , Molnar Maja , Siladi Tena , Masand Vijay Hariram
Published: February 2018

Aims and Objectives: The aim of this study was to derive robust and reliable QSAR
models for clarification and prediction of antioxidant activity of 43 heterocyclic and Schiff bases
dipicolinic acid derivatives. According to the best obtained QSAR model, structures of new compounds
with possible great activities should be proposed.

Methods:

Molecular descriptors were calculated by DRAGON and ADMEWORKS from optimized
molecular structure and two algorithms were used for creating the training and test sets in both set of
descriptors. Regression analysis and validation of models were performed using QSARINS.

Results:

The model with best internal validation result was obtained by DRAGON descriptors
(MATS4m, EEig03d, BELm4, Mor10p), split by ranking method (R2 = 0.805; R2
ext = 0.833; F =
30.914). The model with best external validation result was obtained by ADMEWORKS descriptors
(NDB, MATS5p, MDEN33, TPSA), split by random method (R2 = 0.692; R2
ext = 0.848; F = 16.818).

Conclusion:

Important structural requirements for great antioxidant activity are: low number of
double bonds in molecules; absence of tertial nitrogen atoms; higher number of hydrogen bond
donors; enhanced molecular polarity; and symmetrical moiety. Two new compounds with potentially
great antioxidant activities were proposed.
Herbal Products for Common Auto-Inflammatory Disorders - Novel Approaches
Authors: Suroowan Shanoo , Mahomoodally Fawzi
Published: February 2018

Background:

Common auto-inflammatory disorders (CAIDs) constitute a wide array of
ailments ranging from acute allergies to chronic conditions. Globally, CAIDs remain one of the
leading causes of disability and morbidity. Despite playing a leading therapeutic role, the vast
profusion of anti-inflammatory synthetic agents have not been able to fully resolve a panoply of
CAIDs. Additionally, contemporary synthetic therapy approaches remain bounded by a wide array of
limitations essentially being adverse effects and unaffordable costs. In this advent, the use of herbal
products provides an interesting avenue to explore in view of developing such treatment regimens.

Objective:

This review article endeavors to highlight potential herbal products and isolated
phytochemicals which can be of benefit in the prophylaxis, management, and treatment alongside
avoiding the relapse of CAIDs.

Conclusion:

This review article has highlighted that herbals, herbal products, and isolated
metabolites hold a huge potential in the prophylaxis, management, and treatment of CAIDs. Herbals
can act on various targets involved in the pathogenesis of inflammatory disorders. In addition, novel
approaches for the management of CAIDs are numerous. Indeed, nanoparticles loaded with
phytochemicals have been developed to specifically target the colon for IBD treatment. In silico
approaches using herbals also offer unlimited avenues to decipher new pharmacophores.
Investigating the potential of polyherbal formulations is another unique approach which can be
investigated. Given the inefficacy of conventional medicines, the concomitant use of conventional
and herbal medicines can also be explored.
Determination of Midodrine and its Active Metabolite Desglymidodrine by LC-MS/MS and its Application in Human Pharmacokinetic Studies
Authors: Narenderan S.T. , Meyyanathan S.N. , Babu B. , Yamjala Karthik , Ashwini S.J.
Published: February 2018

Background:

Midodrine (MD) is a prodrug which is converted into Desglymidodrine
(DMD) after oral administration.

Objective: The aim of the present study is to develop and validate a precise, accurate liquid chromatography-
tandem mass spectroscopy (LC-MS/MS) method for the separation and detection of Midodrine
and Desglymidodrine.

Methods:

The quantification of prodrug Midodrine (MD) and its active metabolite Desglymidodrine
(DMD) in human plasma was performed using simple and economical protein precipitation method.
Caffeine was used as an internal standard (IS). LC separation was carried out using Jones C18 column
(4.6mm x 150mm, 3µm). Isocratic elution was performed using 10mM ammonium formate (pH 4.0
adjusted with formic acid): methanol 30:70, v/v as a mobile phase, at a constant of flow of 0.5 ml/min.

Results:

Mass spectrometric detection was carried out at positive electrospray ionization with proton
adducts at m/z 255.0˃237.1, 198.1˃180.2 and 195.0˃138.1 for Midodrine, Desglymidodrine and caffeine
(IS) respectively, in MRM mode. The method was validated over a linear concentration range of
0.3-110 ng/ml (r2 =0.996 and r2 =0.9988) for both Midodrine and Desglymidodrine. The recovery of
Midodrine and Desglymidodrine were found to be 99 ± 0.12%. The precision (intra-day and inter-day)
and accuracy studies fulfilled the acceptance criteria.

Conclusion:

The method shows to be stable for the studied stability parameters and was successfully
applied for clinical pharmacokinetic studies.
Characterization, Purity Determination and Decomposition Kinetics of Ezetimibe Under Non-Isothermal Conditions
Authors: Martins Guilherme A. G. , Murakami Fabio S. , Sangoi Maximiliano S. , Todeschini Vitor , S. Bernardi Larissa , R. Oliveira Paulo
Published: February 2018

Background:

Ezetimibe is a lipid-lowering agent used therapeutically alone or in combination of other drugs. The properties of the solid-state of drugs are critical factors in the pharmaceutical formulation development. Several instrumental techniques can be employed in the analysis of new formulations, but the thermoanalytical techniques, provide a fast and careful evaluation of physicochemical properties of a compound.  Objective: To carry out the physicochemical characterization, purity evaluation and non-isothermal kinetic studies of ezetimibe raw material.

Methods:

A combination of the following different analytical technics was employed: Differential Scanning Calorimetry, Thermogravimetric, Scanning Electron Microscopy, X-ray powder diffraction.

Results:

The results evidenced the crystalline characteristic of ezetimibe. The sample purity was 99.06 % ± 0.02 and the thermal decomposition followed a zero order kinetic, with activation energy of 96.56 kJ mol–1 and Arrhenius frequency factor of 3,442 x 109 min-1.

Conclusion:

The characterization of ezetimibe together with the non-isothermal kinetic degradation represents important studies for the pharmaceutical area, since it provides crucial information for the pharmacotechnical/quality control/production areas that should establish the specifications necessary to standardize the requirements of the raw material acquire to ensure the batch-to-batch reproducibility.
CJK-7, a Novel Flavonoid from Paulownia tomentosa Triggers Cell Death Cascades in HCT-116 Human Colon Carcinoma Cells via Redox Signaling
Authors: Singh Mahendra Pal , Park Ki Hun , Khaket Tejinder Pal , Kang Sun Chul
Published: February 2018

Background:

Colon cancer is the second most common cancer to cause death worldwide. About half
of colon cancers patients require adjuvant therapy to control relapse following surgical resection. Therefore,
abolition of tumor cell progression using an effective chemotherapeutic agent holds a feasible approach to treat
patients suffering from colon cancer. In the present study, we evaluated the effects of geranylated flavonoid
CJK-7, isolated from Paulownia tomentosa on HCT-116 human colon carcinoma cells.

Materials and Methods:

The effects of CJK-7 as an active component on HCT-116 cells programmed cell death
and its underlying molecular mechanism were examined by using MTT assay, morphological assessment,
H2DCFDA staining, Fura-2AM staining, Hoechst-33342 staining, comet assay, Acridine orange staining, mitochondrial
membrane potential (ΔΨm) assay and Western blot analyses.

Results and Conclusion:

The results revealed that, CJK-7 was capable of inducing caspase-dependent cell death
events in cancer cells. Moreover, it was involved in up-regulation of autophagy signaling as evidenced by enhanced
expression of LC3I/II. We also noticed stimulated expression of endoplasmic reticulum stress markers
and phosphorylation of c-Jun NH2-terminal kinase (JNK), which was associated with up-regulated expression of
p53, PUMA, Atg5 and Beclin-1, and down-regulation of Bcl-2, stressing the interaction of ROS on the aforementioned
signaling. Furthermore, exposure to ROS scavengers (N-acetyl-l-cysteine (NAC), and JNK-specific
inhibitor SP600125) significantly reversed the effects of CJK-7 by down-regulating apoptosis and autophagy
signatures in HCT-116 cancer cells. Collectively our findings clarify the ROS-dependent regulatory effect of
CJK-7 on programmed cell death signaling events in HCT-116 cancer cells while depicting its virile pro-oxidant
capacity.
Traditional medicine in the management of Recurrent Tonsillitis - An Ayurvedic Perspective
Authors: Nayak Vijayakumar , Jadhav Vinod , M. R. Sajjanshetty
Published: February 2018

Tonsillitis is one of the commonest infectious illness suffered by pediatric age group. It has high incidence in developing nations like India. Its recurrent attack results in hypertrophy of tonsils, difficulty in swallowing, sleep problems resulting in poor nutrition and poor school performance as well. Recurrent tonsillitis may also result in late complications like rheumatic heart diseases. Conventional systems of medicine usually advise surgical removal of tonsils to treat its recurrent infections. Ayurveda describes a similar condition, Tundikeri which have same clinical manifestations like recurrent tonsillitis and also advised its medicinal treatment. Ayurveda have ample treasure of herbal medicine which can be used in the management of recurrent tonsillitis. This article reviews various classical texts as well as recent experimental and clinical studies to find out herbal medicine useful in recurrent tonsillitis and revalidate their use to reduce necessity of tonsillectomy.
Pathya Apathya and role of Dinacharya in Nethra Swasthya
Authors: Varrier Girish S. , J. Ashwini M.
Published: February 2018

The word Chakshu means, that which illuminates the objects and enlightens the mind about its details. It is seated in the two eye balls. When we talk about Pathya and Apathya, the importance of the word Chakshushya is impressed upon. The Pathyas have been explained by different authors in the heading of Chakshushya Vargas and the Apathyas have been explained as Achakshushya. Different Acharyas have also explained about the various daily regimen to be followed for maintaining Nethra Swasthya as Ayurveda gives much importance in maintaining of health and prevention of diseases along with the treatment of diseases. These Dinacharyas can be adopted in our day to day lives to protect the eye from diseases and improve the vision, by implementing improvised techniques tailor-made for day to day activities of present era. The Acharyas have armed us with proper knowledge to prevent and treat life style disorders related to eye diseases through explanation of Pathya Apathya and Dinacharyas which are practices of Kriyakalpas. Most of these practices are not being followed these days which leads to many Nethra Rogas. This can be corrected by re-implementing improvised versions of such practices in our daily life.
Agrobacterium tumefaciens-mediated transformation of Jatropha curcas L. with a polyhydroxyalkanoate gene (phaC)
Authors: Novatiano Chesara , Pancoro Adi , Marwani Erly
Published: February 2018

Polyhydroxybutyrate is a component of bioplastics that is synthesized under the control of enzymes encoded by pha multigenes. The genes are naturally present in Ralstonia eutropha. However, the production of bioplastics in bacteria is inefficient because the bacterial biomass is relatively small compared with plants or fungi. As such, engineering techniques have been developed that enable pha genes to be inserted into plant biomass, and then be expressed in the biomass of the plant to produce polyhydroxybutyrate. The objectives of this study were to transform the tissue of Jatropha curcas using the phaC gene (a pha gene), to regenerate the transformed plant, and to confirm the presence of the inserted genes with PCR. The genetic transformation of J. curcas was mediated by Agrobacterium tumefaciens strain GV3101 containing pARTC by dipping the cotyledon tissue of J. curcas in a suspension of the bacterium for 30 min, followed by cocultivation for 3 d on Murashige and Skoog (MS) medium. The tissue was then placed on a selection medium, i.e. MS medium containing 13.3 µM BAP and 0.05 µM IBA with the addition of 20 mg/L kanamycin. The results showed that 12.35% of the tissue survived and regenerated into a shoot after 1–2 months. Molecular analysis of the transformed tissue was performed using phaC and nptII primers, in order to detect the presence of the phaC and nptII genes. Specific bands were detected at 659 bp and 700 bp, corresponding to the nptII primer and phaC primer, respectively.
NMR metabolite comparison of local pigmented rice in Yogyakarta
Authors: Wijaya Dio N. , Susanto Febri Adi , Purwestri Yekti Asih , Ismoyowati Dyah , Nuringtyas Tri Rini
Published: February 2018

Pigmented rice may have a black or red color due to higher anthocyanin content in its grain. A natural antioxidant, many studies on anthocyanin have reported its positive effects on human health. This fact has spurred the development of pigmented rice as a functional food. This study aimed to compare the metabolite profiles of black and red rice. Three black rice cultivars, namely Melik, Pari Ireng, and Cempo Ireng Sleman, and two red rice cultivars, Inpari 24 and RC 204, were used. After husk removal, grain samples were ground in liquid nitrogen and dried with a freeze dryer. The dried samples were extracted using 50% MeOD4 (in a D2O phosphate buffer pH 6 containing 0.01% TSP as an internal standard). Metabolomic analysis was performed using 500 MHz NMR followed by multivariate data analysis. An orthogonal partial least squares-discriminant analysis (OPLS-DA) model ađer PCA was constructed to discriminate between the five different cultivars. The resulting OPLS-DA score plot revealed a clear separation between black rice and red rice. The metabolites that could influence the separation of red rice and black rice were valine, threonine, alanine, glutamate, galactinol, β-glucose, α-glucose, raffinose, and fumaric acid.
Allelic diversity of butyrophilin (BTN1A1) gene in Indian bovines
Authors: Kumar Manoj , Ratwan Poonam , Das Ramendra , Chopra Alka , Vohra Vikas
Published: February 2018

Indian milch bovines comprises of 58.56% of total livestock population (512.05 million) in the country and primarily includes native and crossbred cattle (37.28%) and water buffaloes (21.28%). Milk and milk products are essential food items of Indian diet especially in children, old and senile. Milk fat is an important constituent of milk and has an economic value and its percentage in milk varies betweem species and breeds within species. Butyrophilin (BTN1A1) a membrane protein regulates secretion of lipids and size of a fat globule in milk. Present study was conducted in 538 bovines of 11 breeds/populations adapted to different parts of India, with an aim to screen and determine the major allele of BTN1A1 gene using PCR-RFLP based test. Results indicate that exon 8 of BTN1A1 gene is polymorphic in Tharparkar, Sahiwal, Jhari and Belahi populations of native cattle and Holstein Friesian and Jersey crossbreds where as the same exon was monomorphic in Murrah, Chilika, Gojri, Chhattisgarhi and Bargur populations of water buffalo. We conclude that variations in BTN1A1 gene can serve as an excellent genetic marker while selecting cows for higher milk fat and can be applied while formulating their breeding plans.
Flower-Insect Visitor Interaction: Study Case on Rhododendron inundatum Sleumer in Bali Botanic Garden
Authors: Kuswantoro Farid
Published: February 2018

The Rhododendron-insect relationship was quite well studied in the northern hemisphere. However, information on the flower-insect relationship of the Indonesian Rhododendron was limited. This study aims to find the interaction between Rhododendron inundatum Sleumer collected in Bali Botanic Garden and its flower-visiting insect. The study was conducted by observing insect visitation to the flower of R. inundatum for 1 hour a day and repeated for nine days. Data analysis was conducted by calculating the Visitation Rate (VR) of each visitor taxa to determine its frequency. Study result showed that R. inundatum in Bali Botanic Garden was visited mainly by Chrysopa sp., as well as members of the Vespidae, Curculionidae, Muscidae, Drosophilidae, and Tephritidae. The result of this study was dissimilar with the previous study of white-flowered Rhododendron, which was mainly visited by moths.
Twenty-Four–Hour Ambulatory Blood Pressure versus Clinic Blood Pressure Measurements and Risk of Adverse Outcomes in Children with CKD
Authors: Ku Elaine , McCulloch Charles E. , Warady Bradley A. , Furth Susan L. , Grimes Barbara A. , Mitsnefes Mark M.
Published: February 2018

Background

and objectives Our objective was to determine whether clinic BPs (taken at either a single visit or two sequential visits) are inferior to ambulatory BPs in their ability to discriminate risk of adverse outcomes in children with CKD.

Design, setting, participants, & measurements

We included 513 participants of the CKD in Children Study who had clinic BPs and 24-hour ambulatory BP monitoring performed during similar timeframes. Predictors of interest were systolic BPs taken at a single visit or two repeated visits within a 1-year period compared with mean wake and sleep systolic ambulatory BPs. Outcomes were left ventricular hypertrophy and ESKD. We determined the ability for each BP parameter to provide risk discrimination using c statistics.

Results

During mean follow-up of 3.5 years, 123 participants developed ESKD. In cross-sectional unadjusted analysis, every 0.1 increase in systolic BP index was associated with a 2.0 times higher odds of left ventricular hypertrophy (95% confidence interval, 1.5 to 2.8) by clinic BPs versus 1.8 times higher odds (95% confidence interval, 1.3 to 2.4) by ambulatory wake BP. The c statistic was highest for clinic BP (c=0.65; 95% confidence interval, 0.58 to 0.73) but similar to ambulatory wake BP (c=0.64; 95% confidence interval, 0.57 to 0.71) for the discrimination of left ventricular hypertrophy. In longitudinal unadjusted analysis, every 0.1 increase in systolic BP index was associated with a higher risk of ESKD using repeated clinic (hazard ratio, 1.5; 95% confidence interval, 1.3 to 1.8) versus ambulatory wake BP (hazard ratio, 1.6; 95% confidence interval, 1.3 to 2.0). Unadjusted c statistics were the same for wake (c=0.61; 95% confidence interval, 0.56 to 0.67) and clinic systolic BPs (c=0.61; 95% confidence interval, 0.55 to 0.66) for discriminating risk of ESKD.

Conclusions

Clinic BPs taken in a protocol-driven setting are not consistently inferior to ambulatory BP in the discrimination of BP-related adverse outcomes in children with CKD.
EFEKTIVITAS DAUN NANGKA DALAM RANSUM RUMINANSIA TERHADAP, KECERNAAN BAHAN KERING, BAHAN ORGANIK DAN KANDUNGAN TANIN
Authors: Nora Delfia , Astuti Tri , Wahid Darham
Published: February 2018

Penelitian ini bertujuan untuk mengetahui Efektivitas Daun Nangka Dalam Ransum RuminansiaTerhadap, Kecernaan Bahan Kering, Bahan Organik dan Kandungan Tanin.   Daun nangka tersebut  dikombinasikan dengan rumput lapangan sebagai pakan ternak. Penelitian ini dilakukan dengan metode eksperimen menggunakan Rancangan Acak Lengkap. Perlakuan dalam penelitian ini merupakan kombinasi daun Nangka dan rumput lapangan yang terdiri dari : I. 100% Rumput lapangan dan 0% daun nangka, II. 80%   Rumput lapangan dan 20%  daun nangka,  III. 60%  Rumput lapangan dan 40%  daun nangka, IV. 20%   Rumput lapangan dan 80%  daun nangka,   V. 0%   Rumput lapangan dan 100%  daun nangka.  Parameter penelitian ini adalah melihat konsentrasi kandungan tanin dari masing-masing perlakuan, kecernaan bahan kering dan bahan organik. Berdasarkan hasil penelitian terlihat  pengaruh sangat nyata (P<0.01) pada kandungan tanin, semakin tinggi persentase daun nangka dalam ransum perlakuan semakin tinggi kandungan tanin, akan tetapi pengaruh yang tidak nyata terhadap kecernaan bahan kering dan bahan organik .

This researched aimed to know the effect of jackfruit leaves in the ruminant feed on the  tannin content, dry matter and organic matter digestibility.  The jackfruit leaves was combined with the grass field as fodder.  This study used an experimental method a completely randomized design used in combination Jackfruit leaves and grass field with treatment : I. 100% grass field and 0% Jackfruit leaves, II. 80%  grass field and 20%  Jackfruit leaves,  III. 60% grass field and 40%  Jackfruit leaves, IV. 20%  grass field and 80%  Jackfruit leaves,   V. 0%   grass field and 100%  Jackfruit leaves. The parameters of this study was the concentration of tannin content of each treatment, dry matter and organic matter digestibility.  Based on the results of research, there was  highly significant effect (P <0.01) in the treatment ration base of jackfruit leaves on tannin content. The higher tannin content when higher persentage the jackfruit leaves and the no effect significant on dry matter and organic matter digestibility.
SISTEM CERDAS DIAGNOSA PENYAKIT DALAM MENGGUNAKAN JARINGAN SYARAF TIRUAN DENGAN METODE PERCEPTRON
Authors: Usman Usman , Abdullah Abdullah
Published: February 2018

Aplikasi Jaringan Syaraf Tiruan (JST) untuk diagnosa  Penyakit Dalam dengan metode perceptron. Aplikasi ini dibuat untuk mengetahui keakuratan diagnosa Penyakit Dalam menggunakan JST perceptron dan mengimplementasikan JST perceptron berdasarkan gejala-gejala Penyakit Dalam ke dalam matlab dengan tampilan Graphical User Interface (GUI). Penyakit Dalam yang dibahas sebanyak 9 Penyakit Dalam. Yaitu penyakit  Asma bronchial, Anemia, Demam berdarah, Diabetes mellitus, Gagal Jantung, Tetanus, Hipertensi, Hepatitis, dan  Tuberkolosis paru. Gejala penyakit dalam yang diambil berdasarkan data rekam medis penderita Penyakit Dalam dan data pasien yang berobat  di Poli Penyakit Dalam RSUD Puri Husada Tembilahan. Dari hasil pelatihan (training) terhadap 48 data, kecocokan keluaran jaringan dan target yang di inginkan yaitu penyakit dalam 100% dapat dikenali/sesuai dengan target yang di inginkan. Dan hasil pengujian data baru sebanyak 10 kali pengujian menghasilkan keluaran sekitar 78,9 % yang sesuai dengan target dan 21,1% yang tidak sesuai dengan target. Hasil pengujian dan pelatihan di implementasikan ke dalam GUI sebagai aplikasi dan user interface.
PENYERAPAN TEKNOLOGI INFORMASI PADA KEGIATAN IMPLEMENTASI KURIKULUM 2013 DALAM BENTUK APLIKASI PENGOLAHAN NILAI SISWA SEKOLAH MENENGAH PERTAMA
Authors: Iswandy Eka , Fajri Ahmad Fikri
Published: February 2018

Dalam penentuan nilai satu mata pelajaran yang menggunakan kurikulum 2013 di  SMP Negeri 1 Padang terdapat beberapa faktor yang menjadi penilaian  penilaian pertama yaitu penilaian pengetahuan yang terdiri dari nilai harian, nilai tugas, nilai ujian harian, nilai tengah semester, nilai semester. penilaian kedua yaitu penilaian sikap yanng terdiri dari kejujuran, kedisiplinan, tanggung jawab, kepedulian, toleransi gotong royong, kesantunan, percaya diri. penilaian ketiga yaitu penilaian ketrampilan yang terdiri darai praktik, projek, portopolio. demi efisiensi dan efektifitas kerja maka sistem informasi penilaian sangat diperlukan. Ini bertujuan untuk membangun sebuah sistem informasi yang mempunyai kemampuan analisa pemberian nilai siswa, dimana masing-masing penilaian dalam mencapai satu nilai harus melalui beberapa penilaian penilaian pengetahuan,penilaian sikap,penilaian ketrampilan, dalam hal ini guru dapat dengan mudah memberi nilai pada setiap siswa Sistem informasi  ini membantu melakukan penilaian pada setiap aspek aspek, dan perubahan nilai bobot. Hal ini berguna untuk memudahkan pemberian  nilai yang terkait dengan masalah pemberian nilai siswa, sehingga akan di dapatkan nilai yang tepat cepat untuk siswa.

 

In determining the value of the subjects who used the curriculum in 2013 in SMP 1 Padang there are several factors which the assessment is the first assessment of knowledge assessment which consists of the daily value, the value of the task, the value of daily tests, midterm grades, grades semester. A second assessment, the assessment yanng consists of honesty, discipline, responsibility, caring, tolerance, mutual cooperation, politeness, confidence. The third assessment that is comprised riding skills assessment practices, projects, portfolios. for the sake of efficiency and effectiveness, the system of assessment information is needed. It aims to build an information system that has the ability to analyze the provision of student scores, which each assessment in reaching the value must be through some assessment of knowledge assessment, assessment of attitudes, skills assessment, in this case the teacher can easily assign a value to each student. This information system helps make an assessment on every aspect aspect, and change of weight values. It is useful to facilitate the provision of value associated with the problem of giving students grades, so it will be a quick get proper value for students.
Animal combate: um novo instrumento pedagógico para o ensino de ciências e biologia
Authors: Silva Leandra de Amorim da , Massarolli Angélica , Butnariu Alessandra Regina
Published: February 2018

Por vezes os alunos se sentem desmotivados com o modelo de aula tradicional e os jogos didáticos surgem com o intuito de tornar as aulas mais dinâmicas, principalmente em conteúdos complexos, como os de biologia, estimulando o aprendizado. Assim, o trabalho teve como objetivo avaliar a aplicabilidade do jogo “Animal Combate”, como instrumento pedagógico e motivacional para o ensino de temas de biologia e verificar o nível de conhecimento dos alunos após a aplicação do jogo. O jogo foi aplicado em turmas do ensino médio, em que os alunos responderam dois questionários avaliativos, sendo um pré e um pós-atividade didática, com perguntas abertas e de múltipla escolha, sendo avaliados apenas os acertos nas alternativas. O jogo proposto, foi adequado para a série/ano na qual foi aplicado, caracterizando-se como uma ferramenta complementar de ensino e aprendizagem, demostrando um aumento nos acertos das respostas, mostrando-se eficaz como instrumento motivador da aprendizagem do conteúdo de Biologia.
O ABORTO COMO ACONTECIMENTO NA OBRA DE ANNIE ERNAUX
Authors: Fernandes Rodrigues Elisa , Dias Loguercio Sandra
Published: February 2018

O presente artigo parte de um trabalho de tradução do francês para o português do romance autobiográfico L’événement (2000), em que a escritora Annie Ernaux relata e repensa o aborto clandestino que viveu em 1964, na França, a fim de elaborar esse acontecimento traumático. Temos por objetivo apresentar a autora do romance e as características de sua obra, além de refletir acerca da narrativa autobiográfica e da escrita feminina. Como o papel político da escrita é central para a autora, discute-se também a realidade do aborto na França, país onde a prática é legal desde 1975, o que consistiu em uma das principais motivações para a tradução do livro para o Brasil.
Quebec: literatura, história e identidades em conflito
Authors: Passos Moraes Luciano
Published: February 2018

A literatura quebequense caracteriza-se pelo debate em torno do problema do pertencimento, processo observado desde as origens da província e que até hoje provoca a discussão acerca das identidades em contato no Quebec. Tal discussão se intensifica pela presença das chamadas literaturas migrantes, corrente que trouxe ao seio daquele sistema literário a escrita do exilado e do imigrante e, consequentemente, estimulou a abordagem de problemas sociais relacionados à questão da inclusão e à própria resistência em busca da permanência da língua francesa. O presente trabalho pretende traçar um percurso histórico em torno do tema da quebecidade, a partir da releitura de momentos históricos fundamentais que acabaram por preparar o terreno em que emergem tais literaturas.Palavras-chave: literatura quebequense, literaturas migrantes, quebecidade