bluuebunny/crossref_metadata_2025 huggingface dataset:
SATB2-AS1 acts as miR-299-3p sponge to facilitate tumorigenesis in human non-small cell lung cancer
Authors: Wu Xiaofeng , Lu Junti , Chen Wen , Liang Meng , Wang Nan , jlin284@163.com Yanhui Zhou
Published: April 2021

Introduction

Non-small cell lung cancer (NSCLC), the most common pathological type of lung cancer, is partly responsible for an increasing number of tumor-related deaths worldwide. This study aimed to explore the biological role of the anti-sense transcript of special AT-rich sequence binding protein 2 (SATB2-AS1), a novel cancer-related long non-coding RNA (lncRNA), and illustrate the potential molecular mechanisms.

Material and methods

The expression patterns of SATB2-AS1 were determined via qPCR analysis in clinical samples and tumor cell lines. Kaplan-Meier survival analysis was conducted to assess the relationship between SATB2-AS1 expression and survival time of NSCLC patients. NSCLC tumors were transfected with SATB2-AS1 expression vectors or specific short hairpin RNAs (sh-SATB2-AS1). Tumor cell proliferation, cell cycle progression and apoptosis was detected by MTT assays and flow cytometric method, respectively. Nude mouse transplantation models were applied to investigate the effects of SATB2-AS1 on tumor cell growth in vivo. Bio-informatics analysis, luciferase reporter assays and rescue assays were performed to elucidate possible molecular mechanisms.

Results

SATB2-AS1 up-regulation was observed in tumorous tissues and cell lines. Up-regulated SATB2-AS1 expression was associated with shorter overall survival time of patients. SATB2-AS1 over-expression facilitated tumor cell proliferation, cell cycle progression and survival, while its knockdown inhibited tumor cell proliferation, cell cycle progression and survival. SATB2-AS1 depletion suppressed tumor growth in vivo. SATB2-AS1 was revealed to act as a miR-299-3p sponge to exert carcinogenic role.

Conclusions

Our data indicate that SATB2-AS1 acts as a miR-299-3p sponge to facilitate NSCLC development, providing a novel candidate therapeutic target for NSCLC.
Effect of genetic variants in FAS and let-7a on radiation-induced intestinal toxicity in the treatment of prostate cancer
Authors: Guo Honglei , Yuan Feng , Zhu Yancui , He Ling
Published: April 2021

Introduction

The present study aimed to explore the effects of pri-let-7a-1 rs10739971 and FAS-670 rs1800682 polymorphisms on the pathogenesis of radiation induced intestinal toxicity in prostate cancer (PC) patients.

Material and methods

380 PC patients with or without signs of intestinal toxicity were enrolled to study the effects of let-7a rs10739971 and FAS-670 rs1800682 polymorphisms on rectal volume and the risk of intestinal toxicity. In addition, real-time PCR, Western-blot analysis, immunohistochemistry, luciferase assays and computational analyses were performed to explore the mechanism underlying the role of let-7a rs10739971 polymorphism in radiation induced intestinal toxicity.

Results

The let-7a rs10739971 polymorphism but not the FAS-670 rs1800682 polymorphism was closely related to the risk of radiation induced intestinal toxicity featured by a high rectal volume. In addition, there was no obvious association between the rectal volume and the genotype and allele frequencies of FAS -670 rs1800682 and Pri-let-7a-1 rs10739971 polymorphisms. The GG genotype of let-7a rs10739971 polymorphism reduced let-7a expression but enhanced FAS expression. In addition, the intestinal toxicity (-) group showed a much higher level of let-7a and a much lower level of FAS than the intestinal toxicity (+) group. FAS was a virtual target gene of let-7a, which decreased FAS protein expression in a dose-dependent manner.

Conclusions

The GG genotype of pri-let-7a-1 rs10739971 polymorphism could increase the risk of radiation induced intestinal toxicity in PC patients. Therefore, the pri-let-7a-1 rs10739971 polymorphism could be used as a putative marker to predict the risk of intestinal toxicity in PC patients undergoing radiotherapy.
ADGraph: Accurate, Distributed Training on Large Graphs
Authors: Zhang Lizhi , Lai Zhiquan , Liu Feng , Ran Zhejiang
Published: April 2021

Graph neural networks (GNNs) have been emerging as powerful learning tools for recommendation systems, social networks and knowledge graphs. In these domains, the scale of graph data is immense, so that distributed graph learning is required for efficient GNNs training. Graph partition-based methods are widely adopted to scale the graph training. However, most of the previous works focus on scalability other than the accuracy and are not thoroughly evaluated on large-scale graphs. In this paper, we introduce ADGraph (accurate and distributed training on large graphs), exploring how to improve accuracy while keeping large-scale graph training scalability. Firstly, to maintain complete neighbourhood information of the training nodes after graph partitioning, we assign l-hop neighbours of the training nodes to the same partition. We also analyse the accuracy and runtime performance of graph training, with different l-hop settings. Secondly, multi-layer neighbourhood sampling is performed on each partition, so that the mini-batch generated can accurately train target nodes. We study the relationship between convergence accuracy and the sampled layers. We also find that partial neighbourhood sampling can achieve better performance than full neighbourhood sampling. Thirdly, to further overcome the generalization error caused by large-batch training, we choose to reduce batchsize after graph partitioned and apply the linear scaling rule in distributed optimization. We evaluate ADGraph using GraphSage and GAT models with ogbn-products and Reddit datasets on 32 GPUs. Experimental results show that ADGraph achieves better performance than the benchmark accuracy of GraphSage and GAT, while getting 24-29 times speedup on 32 GPUs.
Your Future Employer: Employer Branding, Reputation, and Social Media
Authors: Hanu Charles , Amegbe Hayford , Mensah Philip
Published: April 2021

This study examines employer branding and the relationship between corporate reputation, social media, and the intention of potential applicants to seek future employment. The researchers deployed a structured questionnaire to gather data from national service personnel in Ghana via the WhatsApp platform using a Google Form hyperlink. The proposed conceptual framework was tested based on 581 generated responses. The researchers depended on ADANCO 2.1 software for analysis. This helped in producing the PLS-SEM. The results indicate that the application value, development value, and social value positively impact reputation, which successively influences the intent to apply. The findings also reveal that, where social media influence intention to apply, it does not positively impact corporate reputation. The limitation of this study and directions for future studies are presented.
Using Rasch analysis for determining the cut score of a computer science placement exam
Authors:   The Learning Partnership, McGee Steven , Smith Everett ,   EVS Psychometric Services, Rasmussen Andrew ,   Chicago Public Schools, Gubman Jeremy ,   Chicago Public Schools
Published: April 2021

A key strategy for broadening computer science participation in the Chicago Public Schools has been the enactment of a yearlong computer science course as a high school graduation requirement. The Exploring Computer Science (ECS) curriculum and professional development program serves as a core foundation for supporting policy enactment. However, students with prior background in computer science might find the course repetitive. This paper reports on district efforts to develop a placement exam for students to take an advanced computer science course in lieu of the introductory computer science course. The placement exam tasks were modeled after the ECS exam tasks but with higher difficulty. We used Rasch modeling to equate the placement exam tasks to the ECS exams and to establish a cut score for passing the placement exam.
Possible antivirulent activity of some agents against clinical
isolates of Pseudomonas aeruginosa
Authors: O. Rifai Ahmad , M. Abd El-Aziz Abeer , I. Kenawy Hany
Published: April 2021

Background: Pseudomonas aeruginosa has developed different mechanisms of
resistance against antibiotics and became one of the most life-threatening pathogens.
Fighting against its virulence Factors are an alternative therapeutic target. Objective:
This study was directed towards the investigation of anti-quorum sensing activity and
inhibitory action on virulence factors of different agents including antibacterial agents to which Pseudomonas aeruginosa isolates are resistant and non-antibacterial agents.
Methodology: Anti-quorum sensing activity of ceftriaxone, ceftazidime (CAZ), cefepime
(FEP), vancomycin (VA), paracetamol (PA), and pheniramine maleate (PHE)
investigated as well as their ability to reduce other virulence factors including protease,
hemolysin, and pyocyanin production. Results: This study showed that 3rd and
4th generations cephalosporins could be used as anti-quorum sensing agents effectively in the treatment of Pseudomonas aeruginosa infections, however, vancomycin,
paracetamol, and pheniramine maleate had no effect on inhibiting the studied virulence
factors. Conclusion: From our study we conclude that although cephalosporins at the
used concentrations did not show anti-pseudomonal activity they were effective as anti virulent agents that could be utilized in therapeutically in controlling Pseudomonas
aeruginosa infections.
Role of Interleukin-28 B Gene Polymorphism and Cytomegalovirus Coinfection in Hepatocellular Carcinoma Patients with Chronic Hepatitis C Virus
Authors: M. Abd El Motaleb Tawfik , Sh. Tharwa EL-Sayed , M. Metawea, Eman , O. Khalil Fatma
Published: April 2021

Background: Liver diseases including HCC are life-threatening morbidities.
Mechanisms of HCC are still unclear. Cytomegalovirus (CMV) is DNA virus
characterized by latency and cellular transformation. Genetic polymorphisms
especially SNPs are the most common genetic variation. It plays a critical role in
regulation of cellular interaction and cytokine production. CMV infection and its role
in HCC is under investigation. Objectives: to profile IL28B single-nucleotide
polymorphism in development of HCC in chronic HCV, and identify the relationship
between human cytomegalovirus infection, IL28B SNPs and HCC. Methodology: 120
blood samples were obtained from HCV patients; divided according to clinical,
radiological and laboratory data into three equal groups, forty patients each: HCV,
HCC, LC groups, and 40 normal persons as controls. SNPs of interleukin-28 (IL28B
rs12979860) by RFLP and CMV viral DNA by real-time polymerase chain reaction
were investigated. Results: IL28B /CC genotype was increased significantly in controls
and TT genotype in HCC group. A positive correlation among HCV viral load, CMV
with the genotype IL28B rs12979860/TT especially in HCC group. Conclusions:
IL28B rs12979860/TT is expressed in HCC patients making its role in development of
HCC in CMV positive HCV patients cannot be denied.
Are TEM and CTX Beta-Lactamase genes common among urinary isolates from Ain Shams University Hospitals, Intensive Care Units?
Authors: M. Elsheshtawy Nadia , E. Abdelhamid Amira , Fathy Abdo Fagr , A. Abdel Salam Shimaa
Published: April 2021

Background: Many extended-spectrum β-lactamases (ESBLs) variants are known
among Gram-negative bacilli, and are classified into different structural families as
TEM, SHV, CTX-M, and OXA. Objectives: To detect the distribution of blaTEM and
blaCTX-M genes among the Gram-negative isolates collected from urine samples from
patients admitted to ICUs of Ain Shams University Hospitals, Egypt. Methodology:
Forty Gram-negative urinary isolates were enrolled, and subjected to microbiological
identification and antimicrobial susceptibility testing. Phenotypic detection of ESBLs
production was done. Detection of blaTEM and blaCTX-M genes was done by PCR. Results:
Phenotypically, 8(20%) isolates were ESBL producers and 32(80%) were non ESBL
producers. BlaTEM gene was found in 15 isolates(37.5%) and blaCTX-M gene was found in
8 isolates(20%), while both genes were detected among five isolates. Conclusion:
Molecular methods should be used for definitive identification of ESBLs. BlaTEM gene
was more common than blaCTX-M gene in urine specimens in our setting.
The role of (1,3)-beta-D-glucan (BDG), as noninvasive technique for detection of invasive fungal infection (IFI)
Authors: A. Negm Elham
Published: April 2021

Background: BDG is found in the cell walls of most fungi (eg, Candida, Aspergillus,
Fusarium, Pneumocystis jirovecii). Serum BDG levels is high in the presence of a fungal
infection. Its high serum levels may be detected before development of clinical symptoms
and even prior to isolation or identification of the fungal organism via routine
laboratory methods. Objectives: evaluate the performance of serum (1.3) beta -D glucan
BDG in comparison with blood culture for diagnosis of the invasive fungal infections
with Candida species. Methodology: The study was conducted on 50 patients divided in
3 group first group 20 patients with prolonged stay in ICU receiving broad spectrum
antibacterial treatment, and second group 20 patients with diabetic foot and third group
10 patient healthy subjects with matched sex and age. All patients were subjected to full history taking, clinical examination and laboratory investigations Blood was examined with conventional methods (, Gram stain and culture on fungal media) and serum (1,3) beta -D-glucan was determined by ELISA. Result: The average serum concentration of BDG was higher in group II (121.25±88.9 pg/ml than group I (115.5±90.9 pg/ml),however there is no statistically significantly difference between group I and groupII, themean value of serum (1.3 beta D glucan) in patient with positive blood culture weresignificantly higher than those with negative blood culture there is significant relation between blood culture and the level of(1,3)beta D-glucan in serum. Blood culture could be considered as marker for detection of invasive fungal infection with sensitivity, specificity, PPV and NPV of, 46.43%, 100%, 100% and 11.76% respectively however (1.3) D glucan can detect invasive fungal infection with sensitivity, specificity, PPV and NPV of, 88.46%, 100%, 100% and 40%. Conclusion: Our results suggest that a positive (1,3)beta-D-glucan assay could be a superior test for diagnosis of candidemia in addition to the blood culture
Аналіз потенційних ризиків аудиту аграрних підприємств
Authors: Sysoieva Inna , Zagorodniy Anatoliy , Pylypenko Liubomyr , Tomilin Оleksii , Balaziuk Oksana , Pohrishchuk Oleg
Published: April 2021

Мета. Метою статті є розроблення моделі оцінювання аудиторського ризику на основі нечіткої логіки, систематизація аудиторських дій при наявності ризиків і визначення можливих ризиків діяльності підприємств.
Методологія / методика / підхід. У статті використано загальнонаукові методи дослідження об’єкта й специфічні методи економічних та економіко-математичних досліджень, зокрема, метод аналізу для дослідження видів і структури ризиків аудиторської діяльності, їхніх джерел і факторів впливу; індукції, дедукції, кластерного аналізу й синтезу для ідентифікації ризиків аудиторської діяльності; аналогії, нечіткої логіки та експертного опитування при побудові моделі оцінювання аудиторського ризику; дедукції для визначення способів управління ризиками аудиторської діяльності; основних положень інтегрованого ризик-менеджменту під час дослідження питання організування управління ризиками в аудиторській фірмі.
Результати. Проаналізовано масштаби економічних злочинів і шахрайства в Україні в контексті ідентифікації потенційних ризиків аудиту аграрних підприємств. Проаналізовано розподіл суб’єктів аудиторської діяльності за регіонами України. Науково обґрунтовано використання методичного інструментарію нечіткої логіки для оцінювання ризиків аудиторської діяльності та розроблено відповідну модель оцінювання аудиторського ризику. Вони дають змогу враховувати якісні фактори, що впливають на ризики аудиторської діяльності й невпевненість аудитора в оцінюванні цих факторів.
Оригінальність / наукова новизна. Набули дальшого розвитку теоретичні, методичні та організаційні засади виявлення й оцінювання ризиків аудиту аграрних підприємств. Уперше розроблено модель оцінювання ризиків аудиторської діяльності на основі нечіткої логіки, що має ряд переваг, зокрема, вона дає можливість оперувати словесними оцінками, враховує невпевненість аудитора в оцінках факторів впливу на ризики і є гнучкою й адаптивною. Запропоновано поетапну побудову моделі оцінювання ризиків аудиторської діяльності на основі нечіткої логіки.
Практична цінність / значущість. Практичну цінність мають такі результати дослідження: модель оцінювання аудиторського ризику з використанням апарату нечіткої логіки (після навчання моделі на експериментальних даних); методи управління ризиками аудиторської діяльності. Запропоновані методи ідентифікації та оцінювання ризиків аудиторської діяльності дають змогу підвищити ефективність управління ними для зниження до прийнятного рівня.
Saúde mental em tempos de pandemia de Covid-19 e os profissionais de saúde
Authors: Mucke Ana Cristina , Fassbinder Dessuy Adriana , Kojoroski Ana Paula , Steffani Jovani Antonio , Favero Cetolin Sirlei , Beltrame Vilma , Marmitt Luana Patrícia
Published: April 2021

Objetivo: identificar os desafios da pandemia de COVID-19 à saúde mental dos profissionais de saúde e possíveis intervenções. Método: revisão narrativa a partir das bases de dados e repositórios de preprints disponíveis sobre a COVID-19 (MedRXiv, Scielo Preprints, Pubmed e OMS COVID-19, Global literature on coronavirus disease). Resultados: expressiva carga emocional no trabalho dos profissionais da saúde, com frequentes relatos de depressão, ansiedade, alteração do sono e Síndrome de Burnout. Conclusão: as medidas identificadas foram: redução das jornadas de trabalho, valorização profissional, melhoria nas condições de trabalho, suporte social e psicológico aos profissionais da saúde.
Physical properties and chemical composition of three Ethiopian rice (Oryza sativa Linn.) varieties compared to tef [Eragrostis tef (Zucc.) Trotter] grain
Authors: Legesse Sintayehu
Published: April 2021

Background: It is really crucial to explore physical properties and chemical composition of the locally cultivated cereal crops to enhance their utilization in various recipes. Moreover, that will fill knowledge gaps in this field and provides advantages for both; producers and consumers who still believe that imported cereals are superior to the locals. Aims: This study was intended to investigate the physical properties and chemical composition of the three rice varieties (Edeget, Nerica-4, and X-jigna) in comparison to brown tef which are grown in Ethiopia. The evaluation included determination of thousand kernel weight (TKW), hectoliter weight (HLW), moisture, ash, crude fiber, crude fat, crude protein, carbohydrate, Fe, Zn, Ca, and phytic acid contents. Data Analysis: The data analysis was conducted using SPSS Version-22. Duncan’s multiple range test was used for the mean comparison at p<0.05. Results: The results revealed that the rice cultivar Edeget showed a higher TKW (39.20 g) than other varieties while brown tef had a TKW of 0.36 g. X-jigna displayed a higher HLW (63.70 kg/hL) than other varieties while the brown tef had 84.48 kg/hL. The ash, crude fiber and fat contents of the brown tef were higher than all the three rice varieties. Nerica-4 had better protein content (9.61%) than other rice varieties and brown tef had a protein content of 9.58%. The iron content of the three rice varieties was virtually null while the brown tef had shown a higher iron content (17.18 mg/100g). Nerica-4 had shown a higher zinc content (3.62 mg/100g) while the brown tef had got higher calcium (91.90 mg/100g) and phytic acid (5 mg/g). Conclusions: The study revealed that the physical properties of the three rice varieties were significantly different regardless of the environmental influences.
Keywords: Physical properties, chemical composition, varieties, rice, tef.
ORIENTASI NILAI BUDAYA BATAK TOBA, ANGKOLA DAN MANDAILING DALAM MEMBINA INTERAKSI DAN SOLIDARITAS SOSIAL ANTAR UMAT BERAGAMA DI TAPANULI UTARA (ANALISIS SOSIOLOGIS)
Authors: Firmando Harisan Boni
Published: April 2021

Abstrak

Masyarakat yang beragam sangat perlu dirawat keharmonisannya agar tidak menimbulkan kecurigaan, perbedaan pandangan yang mengarah pada kesalahpahaman, pertentangan dan berujung pada konflik. Sistem Kemasyarakatan Dalihan na tolu yang diorientasikan dalam nilai budaya masyarakat Batak Toba, Angkola dan Mandailing menjadi modal utama dalam membina interaksi dan solidaritas sosial antar umat beragama. Terjadinya silang budaya melalui adaptasi, akulturasi dan asimilasi antara masyarakat lokal dan pendatang menjadi cara dalam membina interaksi dan solidaritas social antar umat beragama di Tapanuli Utara. Metode yang digunakan dalam penelitian adalah metode deskriptif dengan pendekatan kualitatif. Data dikumpulkan dengan observasi dan wawancara. Unit analisis dan informasi adalah masyarakat lokal dan pedatang. Data ditafsirkan menggunakan catatan lapangan.

 

Kata Kunci : Nilai Budaya, Interaksi, Solidaritas Sosial

 

Abstract

   Diverse society really needs to be maintained harmony so as not to arouse suspicion, differences in views that lead to misunderstanding, conflict and lead to conflict. The Dalihan na tolu Community System which is oriented in the cultural values of the Batak Toba, Angkola and Mandailing communities is the main capital in fostering interaction and social solidarity between religious communities. The occurrence of cross culture through adaptation, acculturation and assimilation between local people and migrants is a way to foster interaction and social solidarity between religious communities in North Tapanuli. The method used in this research is descriptive method with a qualitative approach. Data collected by observation and interview. The unit of analysis and information is the local and migrant communities. Data are interpreted using field notes.

 
Keywords : Cultural Values, Interaction, Social Solidarity
DESAFIOS DOS ESTUDANTES TRABALHADORES DE CURSOS DE ADMINISTRAÇÃO, CONTABILIDADE E DIREITO DE UMA INSTITUIÇÃO DE ENSINO SUPERIOR DO OESTE CATARINENSE
Authors: Fischer Augusto , Rover Ardinete , Nodari Tânia Maria dos Santos , Lima Hendy Luci Callegari de
Published: April 2021

Este estudo tem como objetivo analisar os desafios de estudantes de administração, contabilidade e direito de uma IES do Oeste de Santa Catarina. O estudo caracteriza-se pela abordagem qualitativa e quantitativa da pesquisa, e como pesquisa exploratória e descritiva quanto aos fins, com a aplicação dos procedimentos de levantamento tipo survey. A população é constituida de 5.359 estudantes do primeiro semestre de 2019 nos três cursos, para os quais foi enviado questionário semiestruturado por meio do google docs, recebendo-se 227 respostas. Quanto ao perfil, 95% dos estudantes trabalha, são predominantemente do sexo feminino, têm até 24 anos, residem com familiares, e têm renda de até R$ 1.499,00. Os estudantes dedicam até quatro horas diárias, e buscam por meio dos estudos, a formação profissional, melhores oportunidades de trabalho e qualidade de vida, reconhecimento pessoal e prestígio social. A independência financeira é o principal motivo que leva a conciliarem os estudos com o trabalho. As dificuldades percebidas, são típicas entre os estudantes do contexto contemporâneo. Quanto às condições financeiras os estudantes são indiferentes ou percebem terem poucas dificuldades, situação decorrente do apoio familiar, da renda do trabalho e de bolsas de estudo. As expectativas com os cursos frequentados são atendidas e há satisfação com os mesmos. Contudo, também são apontadas insatisfações com o rendimento escolar que, junto com a minoria, cujas expectativas não são atendidas e não está satisfeita com o curso frequentado, indicam lacunas para aperfeiçoamento dos processos de ensino-aprendizagem.
Joint cloud water path and rainwater path retrievals from airborne ORACLES observations
Authors: Dzambo Andrew M. , L'Ecuyer Tristan , Sinclair Kenneth , van Diedenhoven Bastiaan , Gupta Siddhant , McFarquhar Greg , O'Brien Joseph R. , Cairns Brian , Wasilewski Andrzej P. , Alexandrov Mikhail
Published: April 2021

Abstract. This study presents a new algorithm that combines W-band reflectivity
measurements from the Airborne Precipitation Radar – third generation
(APR-3) passive radiometric cloud optical depth and effective radius
retrievals from the Research Scanning Polarimeter (RSP) to estimate total
liquid water path in warm clouds and identify the contributions from cloud
water path (CWP) and rainwater path (RWP). The resulting CWP estimates are
primarily determined by the optical depth input, although reflectivity
measurements contribute ∼10 %–50 % of the uncertainty due to
attenuation through the profile. Uncertainties in CWP estimates across all
conditions are 25 % to 35 %, while RWP uncertainty estimates frequently
exceed 100 %. Two-thirds of all radar-detected clouds observed during the ObseRvations of
Aerosols above CLouds and their intEractionS (ORACLES) campaign that took
place from 2016–2018 over the southeast Atlantic Ocean have CWP between 41
and 168 g m−2 and almost all CWPs (99 %) between 6 to 445 g m−2.
RWP, by contrast, typically makes up a much smaller fraction of total liquid
water path (LWP), with more than 70 % of raining clouds having less than 10 g m−2 of rainwater. In heavier warm rain (i.e., rain rate exceeding 40 mm h−1 or 1000 mm d−1), however, RWP is observed to exceed 2500 g m−2. CWP (RWP) is found to be approximately 30 g m−2 (7 g m−2) larger in unstable environments compared to stable environments.
Surface precipitation is also more than twice as likely in unstable
environments. Comparisons against in situ cloud microphysical probe data
spanning the range of thermodynamic stability and meteorological conditions
encountered across the southeast Atlantic basin demonstrate that the
combined APR-3 and RSP dataset enable a robust joint cloud–precipitation
retrieval algorithm to support future ORACLES precipitation susceptibility
and cloud–aerosol–precipitation interaction studies.
Structure, dynamics, and trace gas variability within the Asian summer monsoon anticyclone in the extreme El Niño of 2015–2016
Authors: Ravindra Babu Saginela , Venkat Ratnam Madineni , Basha Ghouse , Pani Shantanu Kumar , Lin Neng-Huei
Published: April 2021

Abstract. A weak El Niño during 2014–2015 boreal winter developed as a strong
boreal summer event in 2015 which continued and even enhanced during the
following winter. In this work, the detailed changes in the structure,
dynamics, and trace gases within the Asian summer monsoon anticyclone (ASMA)
during the extreme El Niño of 2015–2016 is delineated by using Aura Microwave
Limb Sounder (MLS) measurements, COSMIC radio occultation (RO) temperature,
and National Centers for Environmental Prediction (NCEP) reanalysis products. Our analysis concentrates only on the summer
months of July and August 2015 when the Niño 3.4 index started to exceed values of 1.5. The results show that the ASMA structure was quite different in
summer 2015 as compared to the long-term (2005–2014) mean. In July, the
spatial extension of the ASMA is greater than the long-term mean in all
the regions except over northeastern Asia, where it exhibits a strong
southward shift in its position. The ASMA splits into two, and the western
Pacific mode is evident in August. Interestingly, the subtropical westerly
jet (STJ) shifted southward from its normal position over northeastern Asia,
and as a result midlatitude air moved southward in 2015. Intense Rossby wave
breaking events along with STJ are also found in July 2015. Due to these
dynamical changes in the ASMA, pronounced changes in the ASMA tracers are
noticed in 2015 compared to the long-term mean. A 30 % (20 %) decrease
in carbon monoxide (water vapor) at 100 hPa is observed in July over most of
the ASMA region, whereas in August the drop is strongly concentrated at the
edges of the ASMA. A prominent increase in O3 (> 40 %) at
100 hPa is clearly evident within the ASMA in July, whereas in August the
increase is strongly located (even at 121 hPa) over the western edges of the
ASMA. Further, the temperature around the tropopause shows significant
positive anomalies (∼ 5 K) within the ASMA in 2015. The present
results clearly reveal the El-Niño-induced dynamical changes caused
significant changes in the trace gases within the ASMA in summer 2015.
Insights into Protein Dynamics from 15N-1H HSQC
Authors: Zuiderweg Erik R. P.
Published: April 2021

Abstract. Protein dynamic information is customarily extracted from 15N NMR spin-relaxation experiments. These experiments can only be applied to (small) proteins that can be dissolved to high concentrations. However, most proteins of interest to the biochemical and biomedical community are large and relatively insoluble. These proteins often have functional conformational changes, and it is particularly regretful that these processes cannot be supplemented by dynamical information from NMR. We ask here whether (some) dynamic information can be obtained from the 1H line widths in 15N-1H HSQC spectra. Such spectra are widely available, also for larger proteins. We developed computer programs to predict amide proton line widths from (crystal) structures. We aim to answer the following basic questions: is the 1H linewidth of a HSQC cross peak smaller than average because its 1H nucleus has few dipolar neighbors, or because the resonance is motionally narrowed? Is a broad line broad because of conformational exchange, or because the 1H nucleus resides in a dense proton environment? We calibrate our programs by comparing computational and experimental results for GB1 (58 residues). We deduce that GB1 has low average 1HN order parameters (0.8), in broad agreement with what was found by others from 15N relaxation experiments (Idiyatullin et al., 2003). We apply the program to the BPTI crystal structure and compare the results with a 15N-1H HSQC spectrum of BPTI (56 residues) and identify a cluster of conformationally broadened 1HN resonances that belong to an area, for which millisecond dynamics has been previously reported from 15N relaxation data (Szyperski et al., J. Biomol. NMR 3, 151-164, 1993). We feel that our computational approach is useful to glean insights into the dynamical properties of larger biomolecules for which high-quality 15N relaxation data cannot be recorded.
Sensitive dependence of trajectories on tracer seeding positions – coherent structures in German Bight backward drift simulations
Authors: Callies Ulrich
Published: April 2021

Abstract. Backward drift simulations can aid the interpretation of in situ monitoring data. In some cases, however, trajectories are very sensitive to even small changes in the tracer release position. A corresponding spread of backward simulations implies attraction in the forward passage of time and, hence, uncertainty about the probed water body's origin. This study examines surface drift simulations in the German Bight (North Sea). Lines across which drift behaviour changes non-smoothly are obtained as ridges in the fields of the finite-time Lyapunov exponent (FTLE), a parameter used in dynamical systems theory to identify Lagrangian coherent structures (LCSs). Results closely resemble those obtained considering two-particle relative dispersion. It is argued that simulated FTLE fields might be used in support of the interpretation of monitoring data, indicating when simulations of backward trajectories are unreliable because of their high sensitivity to tracer seeding positions.
El falso testimonio judicial en el Derecho hispánico y anglo-sajón en el Medievo. Estudio comparado
Authors: Rábade Luis Iglesias
Published: April 2021

Este estudio compara las fuentes normativas hispánicas y anglo-sajonas relativas a la regulación del delito de falso testimonio en juicio en el período medieval. En el ámbito hispánico se hace referencia a los antecedentes del Derecho romano, haciendo hincapié en los elementos constitutivos del delito y en los títulos de punición del poder público instituido. Para el período medieval, se propone un método de estudio comparativo diacrónico en paralelo de las fuentes normativas hispánicas y anglosajonas. Para ello, el estudio discurre siguiendo una periodización en cuatro etapas históricas (Alta y Baja Edad Media temprana y tardía, respectivamente) estableciendo en cada una de estas fases los elementos comunes y distintivos de la regulación del delito. El estudio analiza el objeto y los sujetos del delito de falsedad testimonial tanto en las fuentes normativas seculares como canónicas. Por ello, se examina el litigio jurisdiccional, especialmente en los territorios ingleses, entre el poder secular y eclesiástico para enjuiciar al perjuro y sancionarlo de acuerdo a la ley canónica o secular. Se hace también una revisión respecto a cuál es realmente el interés jurídico protegido: la autoridad divina, la víctima o la correcta administración de justicia. En consecuencia, se examina la legitimación para perseguir el delito y la tipología de penas previstas las fuentes normativas seculares y canónicas para tutelar ese bien objeto de protección. En el ámbito hispánico se recurre a la legislación visigoda en el Altomedievo y a los ordenamientos locales y territoriales en la Baja Edad Media, mientras que, en el contexto anglo-sajón, las carencias legislativas se suplen con los compendios del Common Law (especialmente el Britton y el Mirror of Justices), la doctrina jurídica de la época y la práctica forense que se registró en los Year Books respecto a este delito.
Los avatares de un señorío de frontera en la Baja Edad Media. Jódar (Jaén) entre los siglos XIII y XV
Authors: Carmona Ruiz María Antonia
Published: April 2021

En este artículo se estudia las vicisitudes que sufrió el señorío de Jódar desde su conquista, caracterizado por el continuo cambio de titularidad entre los siglos XIII y XV, a consecuencia de su condición fronteriza y de la convulsa vida política que vivió la Corona de Castilla durante esas centurias. Hasta que pasó a formar parte del linaje de los Carvajal, la localidad de Jódar perteneció sucesivamente a Sancho Martínez de Jódar, a los Méndez de Sotomayor, a Enrique y Leonor Enríquez, a Juan Alfonso de Guzmán, a Ruy López Dávalos, a Juan de Perea y Beatriz García de Villandrando, a Pedro y Fernando de Zúñiga y finalmente, a Pedro Girón.
La prostitución en el corazón del capitalismo
Authors: Ranea Triviño Beatriz
Published: April 2021

Reseña:  Rosa Cobo, Editorial Los Libros de la La Catarata, Madrid, 2017, 213 páginas. ISBN: 978-84-9097-326-4
Narrativas sexistas y hostilidad en foros de prensa digital: análisis en diarios de ámbito local.
Authors: Menéndez Menéndez María Isabel , Amigot Leache Patricia , Iturbide Rodrigo Ruth
Published: April 2021

El presente artículo presenta un análisis con perspectiva de género de la participación del público en foros digitales de periódicos a partir de noticias relacionadas con mujeres y/o feminismo. Los objetivos de la investigación buscaban descubrir si existen mensajes de odio y, en su caso, las fórmulas con las que se legitiman. El trabajo de campo utilizó cuatro diarios publicados en la Comunidad Autónoma del País Vasco. El incremento de la capacidad participativa de las audiencias ha transformado las experiencias; en este contexto, este artículo se aproxima al activismo que emplea tecnologías comunicativas para disputar la hegemonía a través de la cual sus participantes proyectan sus códigos y valores en torno a un conflicto. Entre las conclusiones hay que destacar que se ha descubierto una continuidad con el machismo precedente, pero a través de nuevas fórmulas. Los hallazgos revelan la emergencia de un neomachismo que discute los avances en igualdad desde posiciones supuestamente igualitarias al tiempo que cuestiona a las propias mujeres mediante estrategias como el déficit de reconocimiento y el sexismo ambivalente. El estudio pone de manifiesto que los espacios de participación online reproducen las estructuras de poder de género tradicional: los medios digitales no desafían la naturaleza patriarcal.
¿Empoderadas u objetivadas? Análisis de las ciberfeminidades en las influencers de moda.
Authors: Cuenca-Piqueras Cristina , González-Moreno María José , Checa-Olmos Juan Carlos
Published: April 2021

El presente trabajo se analizan nuevos nichos laborales desempeñados por mujeres a través de las nuevas tecnologías y las redes sociales. Partiendo del término influencer, se trata de acotar, en primer lugar, quiénes son; en segundo lugar, revisar los estudios previos sobre la profesión. Con posterioridad, se analizan las posiciones feministas respecto a la instrumentalización del cuerpo, agrupándolas en dos conjuntos, a saber: feminismo hegemónico y feminismo disidente o feminismo pro sexo. Se resumen también los principales estudios sobre influencers que concretan sus perfiles y los temas que tratan en sus colaboraciones, así como su habilidad comunicativa y la transmisión, –o no-, de estereotipos de género. A partir de una selección de las catorce influencers con más alcance en España y los contenidos que publican, tratamos de entender, de un lado, si se reproducen modelos tradicionales de feminidad y, de otro, si estas profesiones realmente empoderan a las mujeres, las cosifican o si se producen ambos fenómenos de manera simultánea. Los resultados muestran que, en la muestra seleccionada, todas las mujeres se corresponden con el “ideal de belleza” occidental. Además, la “mirada masculina” se encuentra presente en los post, a través de la frecuente sexualización de las imágenes, pese a que sus lectoras sean, en su mayoría, mujeres.
The Impacts of Various Media on the Electronic Spectrum of Aniline Violet
Authors:   Department of Chemistry, Factually of Science and Art El Marj, Benghazi University, El Marj, Libya, Hemdan Sokaina , Al Jebaly Asma , Ali Fatma
Published: April 2021

The solvent impact can be decided by Solvent polarity scales, a solvatochromic parameter that has a distinctive position of UV-Visible absorption band within the extend between 250 and 700 nm. The spectral characteristics of Aniline Violet in several solvents at room temperature were analyzed which is that the point of considering the impact of solvents on the absorption spectra of this cationic dye in organic solvent of distinctive characters. The solvent impacts on the wavenumber of the absorption band maxima (max) were talked about utilizing the taking after solvent parameters, refractive index, n, relative permittivity, ε and therefore the empirical solvent polarity ET (30), (*,  and ) and (SA, SB, SP and SPd). The solute–solvent interactions were decided on the premise of multilinear solvation energy relationships concept. The fitting coefficients gotten from this analysis allowed us to estimate the contribution of each type of interactions to the total spectral shifts in solution. The set up dependences between max and the solvent parameters emphasize that the visible band of the examined molecule is influenced by both non-specific and specific solute–solvent interactions. The results appeared the solvent polarizability has major impact on the spectral shift instead of hydrogen bonding accepting ability. Catalan strategy show higher acceptable correlation than Kamlet-Taft methodology and Katritzky methodology. The dissociation constant pKa and the isosbestic point of the explored compound were shown the presence of the individual predominate ionic species was assigned by constructing distribution charts at diverse pH ranges. The results showed that the relative permittivity constant, ε, is important factor affecting on the magnitude of the dissociation constant beside the hydrogen bonding of the solvent.
SISTEMA DE REUSO DE ÁGUA DA CHUVA PARA RESIDÊNCIAS PEQUENAS (70 m²) NO MUNICÍPIO DE RIO VERDE, GOIÁS, CENTRO-OESTE, BRASIL
Authors: Brito Nayara de , Santos Gilmar Oliveira , Rodrigues Gilberto Aparecido
Published: April 2021

A escassez da água vem sendo debatida e argumentada em vários lugares, mostrando a necessidade de ações voltadas ao uso eficiente deste recurso. Assim, o objetivo deste trabalho foi realizar a captação, armazenamento e reuso da água captada de telhado para residência do projeto “Minha Casa, Minha Vida” (70 m2) no município de Rio Verde, Goiás. Foram utilizados dados de precipitação média mensal de 19 anos (1996 - 2015). Simulou-se o armazenamento máximo para assegurar o período de estiagem. Estimou-se o consumo médio de água semanal considerando de 1 a 3 pessoas por residência. Considerou-se como consumo de água lavagem de carro, gramado ou jardim, descarga na bacia, máquina de lavar roupa e lavagem de piso. Nos meses de maior precipitação (novembro-março), conseguiu atender à necessidade das pessoas na residência, e ainda armazenar para aproveitar nos períodos de estiagem. Os meses de fevereiro, março, abril e dezembro, atingiu a capacidade de armazenamento do reservatório (20.000 L) apenas para a residência com 1 e 2 pessoas, para 3 pessoas apenas o mês de março a caixa d’água encheu completamente, sendo assim, supriu as necessidades nos meses de estiagem, onde a demanda não atingiu a capacidade do reservatório. Assim o reuso da água do telhado propicia na economia de água nobre e economia a médio prazo, além de assegurar picos de enchente no período chuvoso.
INTERAÇÃO DE NITROGÊNIO E ZINCO NA PRODUÇÃO DE MILHO
Authors: Finoto Rasteiro Bianca Aparecida , Zufi Junior Francisco Carlos , Fischer Filho João Alberto
Published: April 2021

A cultura do milho é responsiva para aumento de produtividade em função do manejo nutricional e por isto, o trabalho teve como objetivo avaliar a influência do nitrogênio (N) e zinco (Zn) na produção da cultura. O experimento foi conduzido em vasos em área experimental, no município de Bebedouro. Foi instalado em blocos ao acaso, composto por vinte e sete parcelas. Os tratamentos corresponderam a combinações de três doses de Zn (2, 8 e 16 kg ha-1), aplicadas de forma localizada na semeadura e três de N (0, 120 e 240 kg ha-1) aplicadas parceladamente na semeadura e em cobertura. Foram avaliadas as características produtivas: número de fileiras e grãos por espiga e produtividade. A interação entre N e Zn proporcionada pelo uso de 120 kg ha-1 de N e 2 kg ha-1 de Zn resultou em plantas com maior produtividade (30,96 t ha-1). A aplicação de N, não influenciou a quantidade de fileiras por espigas, enquanto doses crescentes de Zn não proporcionam melhor desempenho deste componente de produção. A utilização da maior dose de Zn (16 kg ha-1) exerceu influência negativa sobre a quantidade de grãos por espiga, enquanto a interação entre as doses de 120 kg ha-1 de N e 2 kg ha-1 de Zn representou o tratamento com maior eficiente nesta análise. Doses superiores a 2 kg ha-1 de Zn interagem negativamente junto as doses de 0 e 120 kg ha-1 de N, para as variáveis grãos por espiga e produtividade.
DA PROBLEMÁTICA DA JUDICIALIZAÇÃO DO RISCO HIDROLÓGICO
Authors: Ronquim Filho Adhemar , Cezarino Luciana Oranges
Published: April 2021

Os riscos hidrológicos, aumentados em muito nos últimos anos por alguns períodos de seca, influenciaram muitas decisões judiciais que causaram inadimplência no MCP, o qual ficou paralisado ante a dificuldade de cumprimentos nos contratos da CCEE. O busílis estabelece-se na medida em que os geradores, atingidos por períodos de seca, e sem garantia institucionais, busca a intervenção do Poder Judiciário, o qual, muitos casos, intervêm, concedendo liminares, suspendendo previamente a obrigação de cumprir o contrato de fornecimento de energia. A partir destas decisões, as contratações efetuadas não são cumpridas e os adquirentes são surpreendidos, não recebendo o convencionado, e, por seu turno, também buscam o acolhimento judicial para minimizar seus prejuízos. Neste contexto, surge o presente trabalho, trazendo um pouco da estruturação do setor, o que sintetiza o porquê qualquer intervenção de terceiro na relação desequilibra o arranjo contratual e os órgãos intervenientes. É trazido o PL em trâmite que busca, tardiamente, uma solução para a situação da judicialização desenfreada, mas que transparece não ser a solução definitiva, ao não garantir aos geradores mais estabilidade e segurança ante aos riscos que perdurarão com os momentos de menor precipitação hídrica, bem como aos adquirentes. O estudo aponta que a celeuma poderá manter-se.
CERTIFICAÇÃO AMBIENTAL E INDICADORES DE SUSTENTABILIDADE DA AGRICULTURA
Authors: Borges Fernanda de Freitas
Published: April 2021

O modelo de produção atual da agricultura demanda cada vez mais áreas de plantio e ocasiona a poluição e a destruição dos ecossistemas terrestres. Devido à crescente demanda por alimentos no mundo e o modo como eles são produzidos ocasiona um avanço no esgotamento dos recursos naturais. As mudanças climáticas e o risco de falta de água ameaçam as culturas e as populações mais vulneráveis, indicando um colapso na segurança alimentar e no agravamento da desigualdade e fome no mundo. Minimizar os impactos ambientais da agricultura e agregar valor para a sociedade é um dos princípios fundamentais para que se possa alcançar os objetivos de desenvolvimento sustentável. O objetivo do estudo foi analisar os indicadores oficiais brasileiros de sustentabilidade e os utilizados na aquicultura para elaborar novos indicadores que podem ser utilizados na agricultura e subsidiar as certificações ambientais. Baseado nas diretrizes do IBGE e no que está sendo desenvolvido na aquicultura, foram elaborados dez indicadores ambientais, dez sociais e sete econômicos para a agricultura. Estes indicadores refletem o uso dos recursos naturais, a emissão de resíduos, os impactos causados no ambiente, a inclusão social, a qualidade de vida da população rural e o desempenho econômico do trabalho no campo. Os indicadores propostos se alinham com os objetivos de desenvolvimento sustentável e podem contribuir tanto para mensurar a sustentabilidade dos sistemas de produção agrícola quanto para a implementação das metas de desenvolvimento sustentável aliado aos processos de certificação.
Art, Spectacle, and Permanence. Notes on Le Corbusier and the Synthesis of the Arts
Authors: Moos Stanislaus von
Published: April 2021

In the light of contemporary architecture, last century’s emblematic ‘artist-architect’ may appear at once disquietingly prophetic and almost surrealistically antiquarian. This essay explores the hypothesis that Le Corbusier’s ultimate passion was the museum, and his ultimate dream that of being assigned a key place in the history of art. Though this may sound simple enough - perhaps trivial - it may help re-organizing a very well-known (but also partly unknown) body of knowledge on the master and to understand better the paradox of the continuing presence in current architectural discussions.
On Modern Architecture and Synthesis of the Arts: Dilemmas, Approaches, Vicissitudes
Authors: Torrent Horacio
Published: April 2021

The concept of “synthesis of the arts” became, in the 1940s, a leading principle in the search for renewing and improving modern architecture. Integration with painting and sculpture sought at bringing closer architecture and the people. But many dilemmas stood on the way: from the collaboration processes and the unity of the artistic experience, to “art for art’s sake” predominance or its social content. In the university cities of Mexico and Caracas as well as Burle Marx’s landscapes, the concept of integration reached wider scales. But it found its crisis in the extension to urban planning and the city - which had been, paradoxically, its ultimate target.