bluuebunny/crossref_metadata_2025 huggingface dataset:
A low dose of beryllium exposure influences gut microbiota and promotes metabolic syndrome.
Authors: Cha Kwang Hyun , Yang Jung-Seok , Song Dae-Geun , Yoon Kye-Yoon , Erdene-Ochir Erdenedolgor , Kim Kyung-A , Yoon Hyo Shin , You Hyun Ju , Lim Mi Young , Seo Boram , Jin Jong Beom , Pan Cheol-Ho , Ko GwangPyo
Published: March 2020

Background Elements, including essential minerals and metals, play an important role in human biological functions. Some studies have suggested that exposure to certain elements such as arsenic and cadmium can disturb gut microbiota and result in metabolic disorders. Despite considerable evidence that exposure to toxic heavy metals is significantly associated with host metabolic disorder, few studies have investigated the relationships between fecal elements, gut microbiota, and host metabolism. In order to gain a deeper understanding of the impact of various fecal elements on gut microbiota and metabolic disorder, we have to investigate fecal elements from human stools for association study and demonstrate that certain elements have the causal effect on metabolic disease and changes in gut microbiota. Results We analyzed 28 elements from 304 feces of human twins and evaluated the effects of fecal elements on both gut microbiota and metabolic disorder. Fecal beryllium content was found significantly correlated with biomarkers of metabolic disease and metabolic disease-related gut microbiota such as Akkermansia and Bifidobacterium . In vitro human fecal culture showed marked reduction of species evenness and Bifidobacterium abundance after beryllium treatment. Notably, in mice fed a high-fat diet, 30 ppb of beryllium exposure resulted in significant body weight gain and increased plasma biomarkers for metabolic disorder with an altered microbial community. Beryllium exposure also affected cecal short chain fatty acid profiles, colonic function, and inflammation. Conclusions Our findings indicate that low doses of beryllium, almost similar to the current criteria for beryllium in drinking water, perturb the gut microbiota and worsen metabolic disorders, which is significant implication in public health.
CT manifestations of the coronavirus disease 2019 in patients outside Wuhan: with a history of exposure to Wuhan vs. with second-generation infection
Authors: Wu Yu-ping , Cao Jin-ming , Chen Tian-wu , Li Rui , Liu Feng-jun , Zeng Yue , Zhang Xiao-ming , Mu Qi-wen , Li Hong-jun
Published: March 2020

Objective: To explore discrepancy in CT manifestations of coronavirus disease 2019 (COVID-19) in patients outside Wuhan between cases with a history of exposure to Wuhan and with the second-generation infection.Methods: Twenty-two patients with confirmed COVID-19 from two hospitals in Nanchong outside Wuhan were enrolled. All patients underwent initial and follow-up computed tomography after admission, and were divided into two groups. Group A and B were composed of 15 patients with a history of exposure to Wuhan and 7 with the second-generation infection in Nanchong, respectively. Initial CT features including extent score and density score between groups were statistically compared.Results: All patients in group A had abnormal CT findings while 3 of 7 patients in group B had. Patients with abnormal CT findings were more frequent in group A than in group B (P < 0.05). On initial CT, pure ground glass opacity (GGO), and GGO with consolidation and/or other abnormalities were found in 20% (3/15) and 80% (12/15) patients in group A, respectively, while 1 (14.3%), 2 (28.6%) and 4 (57.1%) had pure GGO, GGO with focal consolidation, and normal CT appearances in Group B, respectively. Patients with extent and density scores of ≥5 were more frequent in group A than in group B (Ps < 0.01). Additionally, 3 of 4 (75%) patients with normal initial CT findings had focal pure GGO lesions on follow-up CT.Conclusion: The COVID-19 in patients with a history of exposure to Wuhan can be severer than with the second-generation infection on CT.
Photosynthetic Activity of Six Hop (Humulus lupulus L.) Cultivars under Different Temperature Treatments
Authors: Eriksen Renée L. , Rutto Laban K. , Dombrowski James E. , Henning John A.
Published: March 2020

The Pacific Northwest grows the majority of hops in the United States; however, the region is experiencing an increase in the number of days with high heat. In addition, there is an increased interest in growing hops in other warmer regions of the United States. To understand how hop plants respond to high temperatures, we measured several physiological traits of six hop cultivars under a range of temperatures from 15 to 45 °C. We found that hop plants achieved maximal carbon assimilation at temperatures of 21 to 39 °C when given sufficient water. At temperatures of 41 °C and higher, all cultivars experienced declines in carbon assimilation. This was likely due to multiple effects on the cell, including damage to photosystem II (PSII), as reflected in declines in FV/FM, damage to membrane integrity as reflected in electrolyte leakage at high temperatures, and declines in Rubisco activity likely due to degradation of Rubisco activase, as reflected in declines in Vc,max. ‘Cascade’, ‘Willamette’, and ‘Southern Brewer’ may be good candidates for growing in warm climates because all experience relatively high rates of carbon assimilation at high temperatures and did not experience significant declines in FV/FM or increases in electrolyte leakage. ‘Chinook’ appeared susceptible to extreme heat stress and exhibited evidence of irreparable damage to PSII and membrane integrity at 45 °C.
Potensi Sekam Padi dan Jerami sebagai Alternatif Material Akustik
Authors: Rohim Ahmad Minanur , Fianti Fianti , Nurbaiti Upik
Published: March 2020

Technology that is increasingly developing produces equipments in the form of information, communication, production, transportation and entertainment facilities. Most of the equipments produce noises. Noise can be reduced by using acoustic dampers. This study aims to determine the potential for sound absorption from rice husks and straw as natural acoustic materials. Materials used include rice husks, rice straw, and resin. 12 cylindrical samples were made. Samples that have been made are tested using a sound absorption measuring instrument that is the impedance tube to measure the value of the sample sound absorption coefficient. The test results show the value of the sound absorption coefficient (α) can be influenced by the thickness. At a frequency of 500 Hz the value of the sound absorption coefficient (α) for each sample is 0.034dB; 0.030dB; 0.030dB; 0.027dB; 0.026dB; 0.027dB; 0.025dB; 0.025dB; 0.025dB; 0.024dB; 0.024dB; 0.023dB; 0.023dB. The sample material is good in research on materials 1 and 2 which have a sound absorption of 0.034 dB and 0.030 dB.
Penerapan Model Pembelajaran Generatif Pada Materi Usaha dan Pesawat Sederhana Kelas VIII MTs Nurussalam Sidogede OKU Timur
Authors: Effendi Effendi , Pantriani Dwi
Published: March 2020

The purpose of this study was to determine the effect of the application of Generative learning models on student learning outcomes in the Work and Simple Machine in MTs Nurussalam Sidogede grade VIII. The type of this research is a quantitative research. The population in this research were students of class VIII at MTS Nurussalam Sidogede consisting of 4 classes. Sampling in this study was randomly drawn. The experimental class uses the generative learning model, while the control class uses the conventional learning model. Data collection techniques using tests, and testing of hypotheses using t-test. Based on student learning outcomes obtained tcount = 3.09 which is more than ttable = 2.01; so it can be concluded that there are significant differences in learning outcomes between students with generative learning models and students with conventional learning models.
Aplikasi Metode Geolistrik untuk Mengetahui Sebaran Batubara di Kabupaten Tulungagung Jawa Timur
Authors: Rusli Rusli , Azizah Elvira , Basid Abdul
Published: March 2020

Research has been conducted aiming to determine the distribution of coal below the surface in Tulungagung Regency. The survey conducted in this study used a Wenner configuration resistivity geoelectric survey. Retrieval of geolithic resistivity data in the field of four trajectories. The results of data collection in the field oneach track are processed using 2D modeling in Res2dinv software. The results of the processing of the two-dimensional modeling are then interpreted. The structure of rock layers containing coal is shown by a yellow, red to dark purple scheme with a resistivity value of 75-350 ohm meters on the inside varying from 0 meters to 6.91 meters below the surface, spreading erratically and patching on each track.
Fire and drinking water capacity enhancement in water distribution networks
Authors: Huzsvar T. , Weber R. , Hos C. J.
Published: March 2020

The purpose of the present study is to introduce a newly developed capacity increment (also pressure sensitivity reduction) technique in the case of drinking water distribution systems (WDS). The main novelty of this method is based on a correlation between two parameters of the water distribution network – one characterises its robustness in a topology-specific way, the other can be calculated with only one hydraulic simulation. With the help of connection the topology optimisation – the identification of the optimal place for installing a new pipe – can be determined within a short processing time, and without the implementation of a stochastic optimiser algorithm. The first part of the paper presents problems caused by high pressure sensitivity and introduces the mathematical background of the method, besides which it discusses the details of the algorithm. After that, the second part presents the results gained by the implementation of the method in two case studies: real-life water distribution systems of a small and a medium-sized town. For the small town, verification is possible by comparing the result of our method with the total hydraulic evaluation of the WDS.
Lipid Drug Conjugates for Improved Therapeutic Benefits
Authors: Shrivastava Priya , Gautam Laxmikant , Jain Anamika , Vishwakarma Nikhar , Vyas Sonal , Vyas Suresh P.
Published: March 2020

Lipid drug conjugates (LDCs) are the chemical entities, which are commonly referred to as lipoidal
prodrug. They contain the bioactive molecules, covalently or non-covalently linked with lipids like fatty acids,
glycerides or phospholipids. Lipid drug conjugates are fabricated with the aim of increasing drug payload. It also
prevents leakage of a highly polar bioactive(s) from the lipophilic matrix. Conjugating lipidic moieties to bioactive
molecules improves hydrophobicity. It also modifies other characteristics of bioactive(s). These conjugates
possess numerous merits encompassing enhanced tumor targeting, lymphatic system targeting, systemic bioavailability
and decreased toxicity. Different conjugation approaches, chemical linkers and spacers can be used to
synthesize LDCs based on the chemical behaviour of lipidic moieties and bioactive(s). The factors such as coupling/
conjugation methods, the linkers etc. regulate and control the release of bioactive(s) from the LDCs. It is
considered as a crucial parameter for the better execution of the LDCs. The purpose of this review is to explore
widely the potential of LDCs as an approach for improving the therapeutic indices of bioactive(s). In this review,
the conjugation methods, various lipids used for preparing LDCs, and advantages of using LDCs are summarized.
Though LDCs might be administered without using a carrier; however, majority of them are incorporated in an
appropriate nanocarrier system. In the conjugates, the lipidic component may considerably improve the loading of
lipoidal bioactive(s) in the lipid compartments. This results in high % drug entrapment in nanocarriers with
greater stability. Several nanometric carriers such as polymeric nanoparticles, micelles, liposomes, emulsions and
lipid nanoparticles, which have been explored, are reviewed here.
Decoding Psoriasis: Integrated Bioinformatics Approach to Understand Hub Genes and Involved Pathways
Authors: Choudhary Saumya , Pradhan Dibyabhaba , Khan Noor S. , Singh Harpreet , Thomas George , Jain Arun K.
Published: March 2020

Background:

Psoriasis is a chronic immune mediated skin disorder with global prevalence of 0.2-
11.4%. Despite rare mortality, the severity of the disease could be understood by the accompanying comorbidities,
that has even led to psychological problems among several patients. The cause and the disease
mechanism still remain elusive.

Objective:

To identify potential therapeutic targets and affecting pathways for better insight of the disease pathogenesis.

Method:

The gene expression profile GSE13355 and GSE14905 were retrieved from NCBI, Gene Expression
Omnibus database. The GEO profiles were integrated and the DEGs of lesional and non-lesional psoriasis skin
were identified using the affy package in R software. The Kyoto Encyclopaedia of Genes and Genomes pathways
of the DEGs were analyzed using clusterProfiler. Cytoscape, V3.7.1 was utilized to construct protein interaction
network and analyze the interactome map of candidate proteins encoded in DEGs. Functionally relevant clusters
were detected through Cytohubba and MCODE.

Results:

A total of 1013 genes were differentially expressed in lesional skin of which 557 were upregulated and
456 were downregulated. Seven dysregulated genes were extracted in non-lesional skin. The disease gene network
of these DEGs revealed 75 newly identified differentially expressed gene that might have a role in development
and progression of the disease. GO analysis revealed keratinocyte differentiation and positive regulation
of cytokine production to be the most enriched biological process and molecular function. Cytokines -cytokine
receptor was the most enriched pathways. Among 1013 identified DEGs in lesional group, 36 DEGs were found
to have altered genetic signature including IL1B and STAT3 which are also reported as hub genes. CCNB1,
CCNA2, CDK1, IL1B, CXCL8, MKI 67, ESR1, UBE2C, STAT1 and STAT3 were top 10 hub gene.

Conclusion:

The hub genes, genomic altered DEGs and other newly identified differentially dysregulated genes
would improve our understanding of psoriasis pathogenesis, moreover, the hub genes could be explored as potential
therapeutic targets for psoriasis.
Realizing the Potential of Blueberry as Natural Inhibitor of Metastasis and Powerful Apoptosis Inducer: Tapping the Treasure Trove for Effective Regulation of Cell Signaling Pathways
Authors: Fayyaz Sundas , Attar Rukset , Xu Baojun , Sabitaliyevich Uteuliyev Y. , Adylova Aima , Fares Mourad , Qureshi Muhammad Z. , Yaylim Ilhan , Alaaeddine Nada
Published: March 2020

Blueberries belong to the genus Vaccinium of the family Ericaceae. Rapidly accumulating experimentally
verified data is uncovering the tremendous pharmacological properties of biologically active constituents of blueberries
against different diseases. Our rapidly evolving knowledge about the multifaceted nature of cancer has opened
new horizons to search for different strategies to target multiple effectors of oncogenic networks to effectively inhibit
cancer onset and progression. Excitingly, whole blueberry powder and various bioactive constituents (pterostilbene,
malvidin-3-galactoside) of blueberries have been shown to efficiently inhibit metastasis in animal models.
These results are encouraging and future studies must focus on the identification of cell signaling pathways effectively
modulated by blueberries in different cancers. It seems exciting to note that researchers are focusing on metastasis
inhibitory effects of blueberry; however, to reap full benefits, it is necessary to take a step back and critically
re-interpret the mechanisms used by active components of blueberry to inhibit or prevent metastasis. JAK/STAT,
TGF/SMAD, Notch, SHH/GLI, and Wnt/ β-Catenin have been shown to be directly involved in the regulation of
metastasis. However, because of limited studies, it is difficult to critically assess the true potential of blueberry. Loss
of apoptosis, metastasis and deregulation of signaling pathways are branching trajectories of molecular oncology.
Accordingly, we have to emphasize on these essential facets to realistically claim blueberry as "Superfood". Different
clinical trials have been conducted to gather clinical evidence about the chemopreventive role of blueberry or its
bioactive components in cancer patients. But it seems clear that because of the lack of sufficient proof-of-concept
studies, we cannot extract significant information about the transition of blueberry into the next phases of clinical
trials. Overview of the existing scientific evidence revealed visible knowledge gaps and a better understanding of the
targets of blueberry will be helpful in efficient and meaningful translation of laboratory findings to clinically effective
therapeutics.
Inventario florístico y vegetación del cráter de la Alberca de Teremendo, Michoacán, México
Authors: Contreras León Jesus , Silva Sáenz Patricia
Published: March 2020

Antecedentes y Objetivos: El cráter de la Alberca de Teremendo de los Reyes, municipio Morelia, es una de las tres albercas volcánicas que existen en Michoacán, México. Actualmente, cuenta únicamente con investigaciones enfocadas al estudio de la calidad del agua y las algas, pero carece de un inventario florístico. Los objetivos de este estudio fueron elaborar una lista de la flora vascular y describir su vegetación. Métodos: Se realizaron 27 recorridos en campo entre octubre 2013 y septiembre 2015, realizando recolectas de material vegetal registrando el hábitat, vegetación y forma biológica de las especies. Se describió la vegetación respecto a su composición, estructura y localización. Se calculó el índice de biodiversidad taxonómica para definir la riqueza de especies por hectárea en comparación con otros estudios regionales. Resultados clave: Se registraron 316 especies de plantas y 12 taxa infraespecíficos, pertenecientes a 228 géneros y 85 familias. La familia mejor representada fue Asteraceae con 39 especies (12.3% del total); a nivel genérico fue Euphorbia con siete especies (2.2%); herbáceas dominan con 235 taxones (74.1%). La vegetación que se describe corresponde a una comunidad vegetal de matorral subtropical, la cual es la mejor representada por la superficie que abarca con aproximadamente 57.3 ha, asociada con elementos de bosque tropical caducifolio, vegetación acuática y subacuática, pastizal y plantas arvenses. Conclusiones: La zona de estudio cuenta con 3.8% de las especies registradas para el estado y 2% de las registradas al municipio. Tiene la mayor afinidad genérica y específica (63.9 y 38.8%, respectivamente) con el cerro del Quinceo. La Alberca de Teremendo destaca florísticamente, ya que en una superficie de extensión limitada (108 ha), alberga una vasta flora con 67.6 especies por ha. Tres especies están en la NOM-059-SEMARNAT-2010: una en la categoría de Amenazada (Erythrina americana) y dos Sujetas a protección especial (Gentiana spathacea y Cedrela odorata).
Novel Interface Designs for Patient Monitoring Applications in Critical Care Medicine: Human Factors Review
Authors: Andrade Evismar , Quinlan Leo , Harte Richard , Byrne Dara , Fallon Enda , Kelly Martina , Casey Siobhan , Kirrane Frank , O'Connor Paul , O'Hora Denis , Scully Michael , Laffey John , Pladys Patrick , Beuchée Alain , ÓLaighin Gearóid
Published: March 2020

Background

The patient monitor (PM) is one of the most commonly used medical devices in hospitals worldwide. PMs are used to monitor patients’ vital signs in a wide variety of patient care settings, especially in critical care settings, such as intensive care units. An interesting observation is that the design of PMs has not significantly changed over the past 2 decades, with the layout and structure of PMs more or less unchanged, with incremental changes in design being made rather than transformational changes. Thus, we believe it well-timed to review the design of novel PM interfaces, with particular reference to usability and human factors.

Objective

This paper aims to review innovations in PM design proposed by researchers and explore how clinicians responded to these design changes.

Methods

A literature search of relevant databases, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, identified 16 related studies. A detailed description of the interface design and an analysis of each novel PM were carried out, including a detailed analysis of the structure of the different user interfaces, to inform future PM design. The test methodologies used to evaluate the different designs are also presented.

Results

Most of the studies included in this review identified some level of improvement in the clinician’s performance when using a novel display in comparison with the traditional PM. For instance, from the 16 reviewed studies, 12 studies identified an improvement in the detection and response times, and 10 studies identified an improvement in the accuracy or treatment efficiency. This indicates that novel displays have the potential to improve the clinical performance of nurses and doctors. However, the outcomes of some of these studies are weakened because of methodological deficiencies. These deficiencies are discussed in detail in this study.

Conclusions

More careful study design is warranted to investigate the user experience and usability of future novel PMs for real time vital sign monitoring, to establish whether or not they could be used successfully in critical care. A series of recommendations on how future novel PM designs and evaluations can be enhanced are provided.
Evaluating Online Consumer Medication Information Systems: Comparative Online Usability Study
Authors: Sigle Stefan , Barriga Pilar , Correa Fernández Francisco Javier , Juhra Christian , Härtel Steffen , Fegeler Christian
Published: March 2020

Background

Medication is the most common intervention in health care, and the number of online consumer information systems within the pharmaceutical sector is increasing. However, online consumer information systems can be a barrier for users, imposing information asymmetries between stakeholders.

Objective

The objective of this study was to quantify and compare the usability of an online consumer medication information system (OCMIS) against a reference implementation based on an interoperable information model for patients, physicians, and pharmacists.

Methods

Quantitative and qualitative data were acquired from patients, physicians, and pharmacists in this online usability study. We administered 3 use cases and a post hoc questionnaire per user. Quantitative usability data including effectiveness (task success), efficiency (task time), and user satisfaction (system usability scale [SUS]) was complemented by qualitative and demographic data. Users evaluated 6 existing systems and 1 reference implementation of an OCMIS.

Results

A total of 137 patients, 81 physicians, and 68 pharmacists participated in this study. Task success varied from 84% to 92% in patients, 66% to 100% in physicians, and 50% to 91% in pharmacists. Task completion time decreased over the course of the study for all but 2 OCMIS within the patient group. Due to an assumed nonnormal distribution of SUS scores, within-group comparison was done using the Kruskal-Wallis test. Patients showed differences in SUS scores (P=.02) and task time (P=.03), while physicians did not have significant differences in SUS scores (P=.83) and task time (P=.72). For pharmacists, a significant difference in SUS scores (P<.001) and task time (P=.007) was detected.

Conclusions

The vendor-neutral reference implementation based on an interoperable information model was proven to be a promising approach that was not inferior to existing solutions for patients and physicians. For pharmacists, it exceeded user satisfaction scores compared to other OCMIS. This data-driven approach based on an interoperable information model enables the development of more user-tailored features to increase usability. This fosters data democratization and empowers stakeholders within the pharmaceutical sector.
DO MICRO SMALL MEDIUM ENTERPRISES (MSMES) NEED MODERN MANAGEMENT ACCOUNTING TECHNIQUES? AN INDONESIAN PERSPECTIVE
Authors: Acintya Amanda
Published: March 2020

Introduction: Management accounting practices (MAPs) have long been recognized as a subject of interest with regards to business performance, including for Micro Small Medium Enterprises (MSMEs). Despite the significant role of this sector in emerging countries, there is a dearth of research into the practical implementation of MAPs. Background Problems: The purpose of this paper is to gain a general understanding of whether modern and traditional MAPs, in the MSMEs’ context, are on an equal footing in terms of usage and perceived importance. We adopt the management accounting (MA) evolution model to structure this research. Novelty: This study contributes by tracing the adoption of MAPs as an indicator of the MSMEs’ need for MA information. Within an academic and regulatory framework, this study is believed to provide an important contribution for academicians, practitioners and the government. Research Methods: We conducted an attended survey of 34 MSMEs around Yogyakarta and used the simple yet meaningful statistical technique of descriptive analytics. Findings/Results: The findings indicate that traditional MAPs (the ones in IFAC stages 1 and 2) were found to be marginally better implemented than the modern MAPs (IFAC stages 3 and 4). We compute the difference of two proxies: extent of implementation (EI) and perceived importance (PI) as an indicator of the gap in their operationalization. We found that as the IFAC stage moves along to the modern MAPs spectrum, the average difference between EI-PI also moves up accordingly. Conclusion: Hence, despite the better implementation of traditional MAPs among the MSMEs, it does not eliminate the opportunity for the increasing usage of modern MAPs in the future.
Financial Reporting for Small and Medium-Sized Enterprises (SMES) In Nigeria: A Review of Literature
Authors: M. Ajekwe Clement C. , Ibiamke Adzor
Published: March 2020

This paper reviews literature of financial reporting by small and Medium-Sized Enterprises (SMEs) with particular reference to Nigeria. The study justifies the use of International Financial Reporting Standards (IFRS) by Nigerian enterprises. Thereafter, the paper recognises the economic importance of SMEs both globally and in Nigeria. Justification for differential reporting between listed entities and unlisted SMEs was articulated. The paper notes the advantages and challenges related to adopting IFRS for SMEs globally and in Nigeria. It is recommended that further research be undertaken to access empirically the impact and consequences of adopting IFRS for SMEs by unlisted enterprises in Nigeria
EVALUATION FEASIBILITY AND BUSINESS DEVELOPMENT STRATEGY ENLARGEMENT WHITE SHRIMP (Litopenaeus Vannamei) AT DUKUHTUNGGAL VILLAGE GLAGAH SUB DISTRICT LAMONGAN
Authors: Lutfi Ika Maulana , Hermawan David , Zubaidah Anis
Published: March 2020

This research aims to analyze the financial feasibility and formulating business development strategies enlargement of White shrimp at Dukuhtunggal Village Sub district Glagah Lamongan. The research using survey method. The sampling method used snowball sampling by the number of respondents as many as 18 people. The result showed that the business of enlarging white shrimp enlargement enterprise development deserves to be implemented and developed, because of the results of the assessment in accordance with the investment criteria Net Present Value (NPV) reached Rp 283.927.334, Net Benefit Cost Ratio (Net/B/C) by 28, Internal Rate of Return (IRR) reached 645.5%, the value of payback period  of 0.37 or three months of seven days and the Profitability index (PI) of 1.53. Business development strategy is known through proceeds from the matrix IFE and EFE with a total score of 3.341 and 3.272. Matrix IE shows the position of the company located on the cell to one which means grow and build so that the appropriate strategy to be applied is the intensive strategy i.e., market penetration, market development, product development and integration strategies. The formulation of the strategy produces eight alternative development strategies i.e., an increase in production capacity, strengthening the institutional role, leveraging capital access, empowerment of farmers, increase the use of quality seeds, weaves cooperation with suppliers, maintaining the condition of the infrastructure, and improve the implementation and monitoring of standard operational procedures. Keywords: Litopenaeus vannamei, feasibility, strategy enlargement
Masculinization of Rainbow Fish (Melanotaenia boesemani) through immersion the larvae with extract of Bee Honey Resin as a natural substance with different doses
Authors: Albasa Ahmad Rusyda Hafidhi , Hakim Riza Rahman , Setyono Budi
Published: March 2020

Abstract. The development of export power ornamental fish offers the potential for ornamental fish the production of Indonesia to global force including the Melanotaenia Boesemani. The difference in value having an economy where a male fish have an economic value higher than the female fish. Based on it, this study aimed to examine the monosex productivity male by the masculinization using natural honey bee resin. Methods used to research this is the method with 4 RAL (0,5 ppm, 1 ppm, 1,5 ppm, and 2 ppm). Data analyzed using analysis (ANOVA) diversity if there is the nature of the treatment and continued with the BNT % 5. The results of the study showed that the bee resin (Propolis) could increase masculinized effect of M.boesemani with average to the percentage male in treatment A 43,92%, B 62,74%, C 50,28%, and D 59,49%, while treatment control of 52,80%. In addition also used the measurement of parameter supporting namely survival rate (SR) with the average treatment A 57,78%, B 44,44%, C 44,44%, D 35,56%, and control of 57,78%. To growth rate (GR) have result treatment A 0,0203g, B 0,0208g, C 0,0215g, D 0,024g, while for control of 0,210g. The quality of water includes the value of doing to the morning ranged from 5,38-8,43 ppm and by day ranged from 5.12-7,67 ppm, while for ph in the morning range 6.5-7.8 and by day ranged from 6.1 a total of 7.3. Based on the research can conclude that Masculinization of M. Boesemani by immersion larvae used honey bee resin (Propolis) with different doses impact against the effects of masculine M.Boesemani best at doses of 1 ppm with percentage 62,74 %.
On the post-truth as a lie
Authors: Pop Rodica
Published: March 2020

The value systems established by centuries have been reversed under the pressure of the political correctness. I intend to talk about a way of communicating and transmitting messages in the public space nowadays. I write about post-truth, arguing that it is a lie cosmeticized, hidden in a language that astounds and is supported by ideas that challenge not only refined intelligence, but also common sense. When I write the word truth, I do not consider the concept of truth, which philosophy strives to define it, but I refer to the instrumental truth, the objective truth with which we operate daily, the truth as a benchmark of stability. And I put this truth in relation to the lie. I offer some concrete examples from the last three decades, from different environments, about events or statements that have been the subject of scandals that have started from the claim of some people to present a lie as a truth. I also refer to the fact that there is a whole Neo-Marxist literature that nullifies the natural hierarchy of things, so that objective truth loses its value, becomes irrelevant, flexible, until it is despised, because it is the instrument of „the conservative” individual, the class enemy of the progressives.
Rorty’s socio-ethnocentrism: the problem of its justification
Authors: Dzhokhadze Igor D.
Published: March 2020

‘Solidarity’ is one of the key concepts of the late Richard Rorty’s philosophy. Arguing that justification of knowledge is a matter of its acceptance by the community, Rorty reduces social relations to the discursive (intertextual or dialogical) ones. Thereby he faces a number of theoretical difficulties. Rorty’s willingness to substitute the idea of objectivity for that of solidarity is at odds with his socio-ethnocentrism. Antirepresentationalist attitude is not shared by the overwhelming majority of Rorty’s ‘cultural peers’, not to mention professional philosophers, but he strongly holds to antirepresentationalism, considering it to be sufficiently justified, not caring about what others think and whether such a strategy is politically relevant or desirable from a pragmatic point of view. Consequently, he endorses the picture of warrant as independent of communal opinion. Western (Anglo-Saxon) ethnocentrism, Rorty argues, is of a special kind: it is the ethnocentrism of a “we-community” (“we liberals”) which is dedicated to enlarging itself and creating more and more variegated, inclusive and heterogeneous society. It’s a worldview of a liberal “ironist” and cosmopolitan who is always aware of the contingency of her language and moral self, and who “has radical and continuing doubts about the final vocabulary she currently uses”. But to say, with Rorty, “We are lucky that our ethnocentrism is based on distrust of itself,” amounts to recognize the truth of anti-ethnocentrism. One who believes in cultural and social progress towards “a global, cosmopolitan, democratic, egalitarian, classless, casteless society” is de facto anti-ethnocentrist. Even if he denies it verbally.
Post-Neo-Kantianism. What is this?
Authors: Noras Andrzej Jan
Published: March 2020

The article attempts to define the concept of “post-neo-Kantianism” based on the nature of its relationship to the concept of “neo-Kantianism”. Concerning this matter, the author poses the following tasks: to characterize the phenomenon of neo-Kantianism, to point out the problems of its definition, to identify the relevance of the term “post-neo-Kantianism” and its relation to the philosophy of I. Kant in particular. The author emphasizes the need to introduce this term in the classification of philosophy of the XX century with the appropriateness of building the model of “Kantianism - Neo-Kantianism - Neo-Neo-Kantianism - Post-Neo-Kantianism”, where each new stage is determined by the nature of the reflection of thinkers of a certain period over the fundamental philosophical problems articulated in Kant's “Critics”. Among the post-Neo-Kantians, A. Noras names thinkers traditionally considered to be german phenomenologists, such as E. Husserl and M. Heidegger: it is from the philosophical concept of Husserl that one can speak of the emergence of post-Neo-Kantianism, and the semantically correct interpretation of Heidegger, according to author, is most clearly understood in the framework of Baden Neo-Kantianism. Investigating the phenomenon of post-Neo-Kantianism, the need is established for answering a question regarding the preceding Neo-Kantian tradition, within which there is still a number of contradictions unresolved in the history of philosophy regarding the classification of Neo-Kantian schools and the distinction between the two periods of Neo-Kantianism: early (classical) and late (“correct”). Neo-Kantianism shows the relevance of Kantian philosophy, highlighting the ongoing debate about understanding the Kantian “Critique of Pure Reason”. Post-Neo-Kantianism plays an important role in terms of the perspectives of modern Kant studies, which include Gottfried Martin, Manfred Brelage, or Hans-Michael Baumgartner.
US - China trade war: reaction of stock exchanges to the transformation of the foreign policy agenda
Authors: Kuchma Nadezhda S.
Published: March 2020

Over one and a half years, the attention of investors around the world has been focused on the confrontation of the two largest economies in the world. The aggravation of trade relations between the United States and China was one of the main reasons for the correction of world markets and the general risk aversion. The shifts and changes triggered by this conflict require more considerable attention since they bring about fundamental transformations of the landscape of international relations and the practice of economic interaction not only in relation to the parties to the conflict but also for the whole world, this conflict is not just a confrontation between the two strongest economies of the world, but also a turning point for updating the configuration of the world order. This article aims to analyze the reactions of US and Chinese stock exchanges in connection with the unfolding of a trade conflict between the two countries and assess the level of adaptability of two economies to external challenges. The methodology of this study bases on the fundamentals of the general economic theory and the general theory of conflict resolution - the research bases on the comparative method. The significant elements composing the scholars' analysis of political reality underlying the conflict is presented as well as stock exchanges’ dynamic through the development of the confrontation. The main conclusion of this study was that this conflict is not just a confrontation between the two strongest economies of the world, but also a turning point for updating the configuration of the world order.
Introduction of microgeneration and energy-saving technologies within the concept of green economy: foreign experience and Russia
Authors: Gomonov Konstantin G. , Sipakova Polina O. , Chapurnaya Anastasia P.
Published: March 2020

The aim of this work is a comparative analysis of the level of development of microgeneration and energy-saving technologies in the framework of the national economy of Russia and the world. The relevance is predetermined by the rapid growth of the investment policy of microgrids and energy-saving technologies based on renewable energy sources (2.6 trillion dollars). Basic information research provided analytical reviews, reports and analytical materials, specialized international departments and agencies, the Ministry of Energy of the Russian Federation, as well as the work of Russian and foreign scientists. Understanding the large-scale tasks related to the development, as well as the development of national and international relations, are an incentive for the pursuit of cleaner, primarily technologies. By 2030, provided that the current course on sustainable development is maintained, the green economy should grow to 10 % of the gross world product. Microenergy is an energy-efficient energy source in the restructuring of Russia's energy sector - the transition from a centralized system, the use of large sources of electricity production, the use of various energy sources that are most suitable for these environmental conditions and the characteristics of natural consumers. Reducing the negative impact of pollution on health and the environment can significantly reduce the burden on the economy, thereby freeing up resources for its growth. The transition of the global economy to a model of green growth will require significant efforts to expand international cooperation. This will require consistent government policies over many years. It is advisable for Russia to join in the development of methodologies and the creation of tools for implementing green initiatives.
Russia and Kazakhstan: range and dynamics of relations in the conditions of increasing interdependence of national economies
Authors: Gusakov Nikolai P. , Maslova Mariia V.
Published: March 2020

The article reveals the changing role of Russia in Kazakhstan’s economy, identifies its position in trade, investment and humanitarian assistance to the country. The economic potential of Kazakhstan is described, the sectors of the economy most attractive to foreign investors are presented. The main countries seeking to increase their presence in Kazakhstan are identified, their place and role in trade and direct investment in Kazakhstan are compared. The separation of spheres of influence in the country is revealed. It is noted that the EU countries are the leading trade partners of Kazakhstan, but the largest imports to the country come from Russia, in the first place in investments are the Netherlands, then the United States. The most active humanitarian aid to Kazakhstan is provided by China, which pursues an active social policy. The article also analyzes the dynamics of changes in the role of Russia, it is revealed that the country is gradually losing its degree of influence in Kazakhstan, however, at the moment it still remains its main strategic partner.
Current global trends in the diamond market and their impact on the development of diamond complexes of Russia and India
Authors: Maltseva Olesia A. , Khromova Natalia G.
Published: March 2020

The article deals with the current trends of the development of the global diamond complex. The authors draw attention to the growing position of lab-grown diamonds on the diamond market, their impact on the natural diamond market and the growing influence of digital technologies in all segments of the diamond complex. The article also presents some information on changes in the new generation of buyers’ preferences at the present time. The authors also pay attention to the problem of the availability of sources of financing for the industry. The aim of the article is to identify how current trends will affect the development of the diamond complexes of Russia and India. The article is rather relevant as the authors has studied the latest published materials on this subject and analyzed the opinions of practitioners. The results of the investigation are presented in the form of a detailed study of current trends and potential threats to the diamond complexes of Russia and India. In conclusion the authors present the idea that there is the need for a new development strategy for the diamond complexes of Russia and India.
Memórias da violência em “Amuleto” de Roberto Bolaño
Authors: De Araújo Menezes Norma Sueli , Costa Julia Morena
Published: March 2020

Este ensaio objetiva apresentar uma análise da violência presente no livro “Amuleto” do escritor chileno Roberto Bolaño. O romance está contextualizado no início da década de 1970, momento de grandes tensões políticas e de significativa violência no México e do início da ditadura militar-empresarial chilena (1973-1990). Os regimes ditatoriais, embora em circunstâncias diferentes, foram (e são ainda) episódios marcantes que unem os países latino-americanos. Identificaremos as diversas formas de violência ocorridas na América Latina, especificamente, no Chile e no México durante o período mencionado, assim como, qual a relação entre a política e a literatura presentes na referida obra. Os atuais discursos políticos que circulam em nossa sociedade sinalizam que grande parte da população brasileira provavelmente ignora parte significativa da história, inclusive do Brasil, nas décadas de 1960/1970, ou seja, a memória produzida sobre este período não deu conta de fazer conhecer os horrores e as atrocidades cometidos durante os mais de 20 anos de governo militar no país. A partir da abordagem do lugar da poesia e dos poetas na década de 1970, a narradora de Amuleto versa sobre seu papel de defensora da poesia e da memória política do México e do Chile de meados do século XX, de forma indissociável. Com seu discurso circular, calcado na reiteração de eventos traumáticos que presenciou, em especial, à invasão à UNAM, o Massacre de Tlatelolco (1968) e o golpe militar chileno (1973). Neste último fato, relatado pelo personagem Arturo Belano, há um trabalho de escavação memorialística, tanto nas ocorrências históricas mencionadas, como dos intentos poéticos do distrito federal mexicano. Os jovens poetas narrados pela protagonista defendiam o livre trânsito entre vida e poesia, se opunham aos moldes acadêmicos vigentes encarnados na figura de Octavio Paz, como também do poder hegemônico. O movimento poético desses jovens latino-americanos da década de 1970 agrega as muitas inquietações dos seus integrantes. A paixão pela poesia é o princípio básico que dá unidade ao grupo que buscava em cada ato e em cada verso um novo modo de explicar o mundo através de uma poesia sem burocracias, sem espaços de poder e legitimações padronizadas. Este estudo contribui para a indispensabilidade de se manter vivos os horrores e traumas que aconteceram durante os regimes autoritários e as ditaduras militares na América Latina e suas reverberações, considerando, sobretudo, que a memória pode ser um potente instrumento utilizado na reconstrução da história. Serão utilizados textos teóricos e críticos de Paul Ricoeur (1996), Nascimento (2008), Seligmann-Silva (2003), Sarlo (2007) e Rojo (2012), Bolognese (2009), Villarreal (2011), entre outros.
Sheffer type degenerate Euler and Bernoulli polynomials
Authors: Kim Taekyun , Ryoo Cheon
Published: March 2020

In this paper, we study some special polynomials which are related to Sheffer
sequence. In addition, we give some new identities for these numbers and
polynomials.
At the end of the debate about canons: Categories, evaluation and the nature of aesthetic value
Authors: Jovanovic Monika
Published: March 2020

The public opinion in philosophy is guided by a multitude of factors and
sometimes an idea gets general recognition but is systematically studied only
after a few decades have passed. There aren?t many papers in contemporary
aesthetics that can match the originality and influence of Kendall Walton?s
?Categories of Art?. It is unsurprising, then, that contemporary
aestheticians often expand upon its main theses. Nevertheless, even after
almost half a century from its first publication, an exhaustive and
comprehensive interpretation of Walton?s paper is still lacking. Moreover,
even Walton himself doesn?t provide a detailed elucidation of his ideas, many
of which are merely outlined in his seminal paper. Furthermore, he doesn?t
apply his view to evaluative aesthetic judgments, even though such an attempt
could today, when the debate about aesthetic canons is on the wane, might
help us understand the nature of aesthetic evaluation. The goal of this paper
is to once again shed some light on the significance of Walton?s approach and
on its reception in contemporary aesthetics.
Naming Convention, Interchangeability, and Patient Interest in Biosimilars
Authors: Socal Mariana P. , Garrett Jace B. , Tayler William B. , Bai Ge , Anderson Gerard F.
Published: March 2020

Although biosimilars may offer cost savings over their comparable biologics, use of biosimilars in the United States remains relatively low. This study investigates two barriers to uptake of biosimilars in the United States. First, the U.S. Food and Drug Administration requires that four-letter suffixes be added to the nonproprietary names of all biosimilars, as well as to the nonproprietary names of all biologics approved after March 2020. Second, biosimilars are not interchangeable with their reference biologic product at the pharmacy counter; a new prescription is needed for the biosimilar to be dispensed in place of the biologic. We conducted two behavioral experiments to examine the effects of the naming convention and interchangeability designation on patients’ interest in biosimilars. We found that, absent the mention of needing a new prescription, adding four-letter suffixes to biosimilars’ nonproprietary names decreased participants’ likelihood of using the biosimilars. When participants were told whether a biosimilar required a new prescription, they were more interested in the biosimilar when it did not require a new prescription, and this effect was driven by participants’ perceived similarity of the biosimilar to the biologic. The effect of interchangeability dominated the suffix effect. Our results suggest that both biosimilar suffixes and interchangeability issues provide signals to patients regarding the perceived similarity of biosimilars to their reference biologics and influence patient usage of biosimilars.