bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Analysis of Heat Transfer in a Type B LNG Tank Pre-Cooling Process Using Various Refrigerants
Authors: Sun Qiang , Zhang Yanli , Lv Yan , Peng Dongsheng , Zhang Siyu , Lu Zhaokuan , Yan Jun
Published: August 2024

This study presents a comprehensive three-dimensional Computational Fluid Dynamics (CFD) analysis of the pre-cooling process of a Type B LNG tank using various refrigerants, including liquid nitrogen (LN), nitrogen gas (NG), liquefied natural gas (LNG), boil-off gas (BOG), and their combinations. The simulation model accounts for phase change (through the mixture multiphase model), convective heat transfer, and conjugate heat exchange between the fluid and the tank structure. The results indicate that liquid nitrogen is the most efficient refrigerant, achieving the highest cooling rate through both latent and sensible heat. LNG also demonstrated a relatively high cooling rate, 79% of that of liquid nitrogen. Gas-only pre-cooling schemes relying solely on sensible heat exhibited slower cooling rates, with BOG achieved 79.4% of the cooling rate of NG. Mixed refrigerants such as NG + LN and BOG + LNG can achieve comparable, while slightly slower, cooling than the pure liquid refrigerants, outperforming gas-only strategies. A further assessment of the heat transfer coefficient suggests the mixed cooling schemes have almost identical heat transfer coefficient on the inner tank surface to the liquid cooling scheme, over 5% higher than the gas refrigerants. The study also highlighted the uneven temperature distribution within the tank due to the bulkhead’s blockage effect, which can induce significant thermal stress and potentially compromise structural integrity. Mixed schemes exhibit thermal gradients higher than those of gas schemes but lower than those of liquid schemes, while achieving cooling speeds comparable to liquid schemes if the inlet velocity of the refrigerants is properly configured. These findings offer valuable insights for developing safer and more efficient pre-cooling procedures for Type B LNG tanks and similar cryogenic storage tanks.
Calibration under Uncertainty Using Bayesian Emulation and History Matching: Methods and Illustration on a Building Energy Model
Authors: Domingo Dario , Royapoor Mohammad , Du Hailiang , Boranian Aaron , Walker Sara , Goldstein Michael
Published: August 2024

Energy models require accurate calibration to deliver reliable predictions. This study offers statistical guidance for a systematic treatment of uncertainty before and during model calibration. Statistical emulation and history matching are introduced. An energy model of a domestic property and a full year of observed data are used as a case study. Emulators, Bayesian surrogates of the energy model, are employed to provide statistical approximations of the energy model outputs and explore the input parameter space efficiently. The emulator’s predictions, alongside quantified uncertainties, are then used to rule out parameter configurations that cannot lead to a match with the observed data. The process is automated within an iterative procedure known as history matching (HM), in which simulated gas consumption and temperature data are simultaneously matched with observed values. The results show that only a small percentage of parameter configurations (0.3% when only gas consumption is matched, and 0.01% when both gas and temperature are matched) yielded outputs matching the observed data. This demonstrates HM’s effectiveness in pinpointing the precise region where model outputs align with observations. The proposed method is intended to offer analysts a robust solution to rapidly explore a model’s response across the entire input space, rule out regions where a match with observed data cannot be achieved, and account for uncertainty, enhancing the confidence in energy models and their viability as a decision support tool.
Condition Monitoring Using Digital Fault-Detection Approach for Pitch System in Wind Turbines
Authors: Saci Abdelmoumen , Nadour Mohamed , Cherroun Lakhmissi , Hafaifa Ahmed , Kouzou Abdellah , Rodriguez Jose , Abdelrahem Mohamed
Published: August 2024

The monitoring of wind turbine (WT) systems allows operators to maximize their performance, consequently minimizing untimely shutdowns and related hazard situations while maximizing their efficiency. Indeed, the rational monitoring of WT ensures the identification of the main sources of risks at a proper time, such as internal or external failures, hence leading to an increase in their prevention by limiting the faults’ occurrence regarding the different components of wind turbines, achieving production objectives. In this context, the present paper develops a practical monitoring approach using a numerical fault-detection process for the pitch system based on a benchmark wind turbine (WT) model with the main aim of improving safety and security performance. Therefore, the proposed fault-diagnosis procedure deals with eventual faults occurring in the actuators and sensors of the pitch system. In this proposed approach, a simple, logical process is used to generate the correct residuals as fault information based on the redundancy in the actuators and sensors of the pitch sub-systems. The obtained results demonstrate the effectiveness of this proposed process for ensuring the tasks of the fault diagnosis and condition monitoring of the WT systems, and it can be a promising approach for avoiding major damage in such systems, leading to their operational stability and improved reliability and availability.
Recent Developments in Supercritical CO2-Based Sustainable Power Generation Technologies
Authors: Tamilarasan Saravana Kumar , Jose Jobel , Boopalan Vignesh , Chen Fei , Arumugam Senthil Kumar , Ramachandran Jishnu Chandran , Parthasarathy Rajesh Kanna , Taler Dawid , Sobota Tomasz , Taler Jan
Published: August 2024

Global warming and environmental pollution from greenhouse gas emissions are hitting an all-time high consistently year after year. In 2022, energy-related emissions accounted for 87% of the overall global emissions. The fossil fuel-based conventional power systems also need timely upgrades to improve their cycle efficiency and reduce their impact on the environment. Supercritical CO2 systems and cycles are gaining attention because of their higher efficiencies and their compatibility with varied energy sources. The present work is a detailed overview of the recent developments in supercritical CO2-based power generation technologies. The supercritical CO2-based Brayton and Rankine power cycles and their improvisations in industrial applications are also discussed in detail. The advances in heat exchanger technology for supercritical CO2 systems are another focus of the study. The energy, exergy, and economical (3E) analysis is carried out on various supercritical CO2 power cycles reported in the literature and the data are concisely and intuitively presented. The review concludes by listing the identified directions for future technology development and areas of immediate research interest. A roadmap is proposed for easing the commercialization of supercritical CO2 technologies to immediately address the growing challenges and concerns arising from energy-related emissions.
Simulating the Long-Term Response of Forest Succession to Climate Change in the Boreal Forest of Northern Ontario, Canada
Authors: Larocque Guy R. , Bell F. Wayne , Searle Eric B. , Mayor Stephen J. , Schiks Thomas , Kalantari Parvin
Published: August 2024

The effect of climate change on forest dynamics is likely to increase in importance in the forthcoming decades. For this reason, it is essential to predict the extent to which changes in temperature, precipitation, and atmospheric CO2 might affect the development of forest ecosystems and successional pathways. The gap model ZELIG-CFS was used to simulate the potential long-term effects of climate change on species-specific annual change in mean basal area and stand density under two scenarios of representative concentration pathways (RCP), 4.5 and 8.5, for the boreal forest region of Ontario, Canada, where mean temperature, precipitation, and atmospheric CO2 are expected to increase. Forest ecosystems in this boreal region included pure and mixed stands of black spruce (Picea mariana [Mill.] B.S.P.), paper birch (Betula papyrifera Marsh.), balsam fir (Abies balsamea [L.] Mill.), jack pine (Pinus banksiana Lamb.), trembling aspen (Populus tremuloides Michx.), white spruce (Picea glauca [Moench] Voss), northern white cedar (Thuja occidentalis L.), American larch (Larix laricina [Du Roi] K. Koch), and balsam poplar (Populus balsamifera L.). Simulation results under climate change generally predicted a decline in the basal area and stand density for black spruce, balsam fir, jack pine, and white spruce, but an increase for paper birch, trembling aspen, American larch, and balsam poplar. However, the extent of change differed regionally among species. Forest composition is expected to change over the long term. Simulation results indicated that shade-intolerant deciduous and conifer species will increase their dominance over the 100-year time horizon. This transition toward the increasing presence of deciduous forests is likely explained by more favorable temperature conditions for their growth and development.
Pharmaceutical Fermentation: Antibiotic Production and Processing
Authors: Zhgun Alexander A.
Published: August 2024

The widespread introduction of antibiotics into medical practice, starting in the late 1940s and early 1950s, radically transformed healthcare, raised it to a qualitatively new level, allowed saving human lives in previously hopeless situations, and became one of the most important factors leading to an increase in the life expectancy of the population of Earth by more than 20 years [...]
Exploring Social Media to Understand Perceptions of Milk Quality among Farmers, Processors, and Citizen-Consumers
Authors: Paleologo Michele , Castellini Greta , Bosio Albino Claudio , Fontana Michele , Graffigna Guendalina
Published: August 2024

Milk consumption is crucial for a balanced diet, yet recent trends indicate a decline, especially in Italy. A significant factor in this decline is the altered perception of milk quality among consumers, which has created a communication gap between them and other stakeholders. This study aimed to explore the discourse on social media and sentiment towards the concept of milk quality among consumers, farmers, and processors. The research adopted social media analysis to examine online-community messages. A sample of 19,906 Italian comments and posts mentioning keywords “milk”, “quality”, “cow”, and “vaccine” was collected and categorized using term-frequency analysis, correspondence analysis, and sentiment analysis. Results highlighted gaps in perceptions of milk quality: farmers focused on economic issues, consumers on animal welfare and health, and processors on lactose content. For farmers, almost all comments were negative, while for processors, nearly all comments were positive. Consumers presented a more mixed picture. This work contributes to the literature by expanding research on milk quality, using social media as a source of information. The findings suggest that enhancing communication and understanding among these groups could lead to more effective strategies for addressing consumer concerns, potentially reversing the decline in milk consumption.
Determination of the Hubble Constant and Sound Horizon from Dark Energy Spectroscopic Instrument Year 1 and Dark Energy Survey Year 6 Baryon Acoustic Oscillation
Authors: Lozano Torres Jose Agustin
Published: August 2024

We perform new measurements of the expansion rate and the sound horizon at the end of the baryon decoupling, and derive constraints on cosmic key parameters in the framework of the ΛCDM model, wCDM model, non-flat ΛCDM model and the phenomenological emergent dark energy (PEDE) model. We keep rd and H0 completely free, and use the recent Dark Energy Spectroscopic Instrument (DESI) Year 1 and Dark Energy Survey (DES) Year 6 BAO measurements in the effective redshift range 0.3<z<2.33, combined with the compressed form of the Pantheon sample of Type Ia supernovae, the latest 34 observational H(z) measurements based on the differential age method, and the recent H0 measurement from SH0ES 2022 as an additional Gaussian prior. Combining BAO data with the observational H(z) measurements, and the Pantheon SNe Ia data, we obtain H0=69.70±1.11 km s−1Mpc−1, rd=147.14±2.56 Mpc in flat ΛCDM model, H0=70.01±1.14 km s−1Mpc−1, rd=146.97±2.45 Mpc in PEDE model. The spatial curvature is Ωk=0.023±0.025, and the dark energy equation of state is w=−1.029±0.051, consistent with a cosmological constant. We apply the Akaike information and the Bayesian information criterion test to compare the four models, and see that the PEDE model performs better.
Whole Genome Analysis in Consanguineous Families Reveals New Loci for Speech Sound Disorder (SSD)
Authors: Yasmin Tahira , Sadia Aatika , Nadeem Laraib , Basra Muhammad Asim Raza , Rice Mabel L. , Raza Muhammad Hashim
Published: August 2024

Speech is the most common means of communication in humans. Any defect in accurate speech production ability results in the development of speech sound disorder (SSD), a condition that can significantly impair an individual’s academic performance, social interactions, and relationships with peers and adults. This study investigated the genetic basis of SSD in three Pakistani families. We performed family-based genome-wide parametric linkage analysis and homozygosity mapping in three consanguineous families with SSD from the Punjab province of Pakistan. The Test for Assessment of Articulation and Phonology in Urdu (TAAPU) was used to analyze the speech articulation data and determine the Percentage Correct Consonants (PCC) score. The PCC score defined the affected and unaffected individuals in each family. Parametric linkage analysis revealed a linkage to chromosome 5 (5q21.3-5q23.1) with a significant logarithm of the odds (LOD) score of 3.13 in a Pakistani family with specific language impairment-97 (PKSLI-97) under an autosomal recessive mode of inheritance. The other two families showed a suggestive linkage at 6p22.1, 14q12, and 16q12.1 under the recessive mode of inheritance. Interestingly, homozygosity mapping showed a loss of heterozygosity in the linkage region at 5q15-5q23.1, shared among seven affected (mostly in the younger generation) and one unaffected individual of PKSLI-97. Our analysis identified the 6p22 locus previously implicated in dyslexia, childhood apraxia of speech (CAS), and language impairment, confirming the role of KIAA0319 and DCDC2 in this locus. These findings provide statistical evidence for the genomic regions associated with articulation disorder and offer future opportunities to further the role of genes in speech production.
Long-Term Outcomes (10 Years) of Sacrospinous Ligament Fixation for Pelvic Organ Prolapse Repair
Authors: Vigna Annalisa , Barba Marta , Frigerio Matteo
Published: August 2024

Vaginal vault prolapse is one of the main reasons for reoperation in patients with pelvic organ prolapse. Effective correction of the vaginal apex is essential for lasting repair for these women. Apical suspension of the sacrospinous ligament is probably one of the main vaginal treatments still offered to patients today. We proposed an evaluation of the functional and anatomical results of long-term sacrospinous ligament fixation. Objective: The purpose of this study was to evaluate the 10-year results of sacrospinous ligament suspension as primary repair for apical prolapse and to evaluate long-term side effects. Materials and Methods: A retrospective study analyzed 10-year follow-up after prolapse repair using sacrospinous ligament suspension. A subjective recurrence was identified as the postoperative occurrence of swelling symptoms based on a particular item on the Italian Prolapse Quality of Life (P-QoL) questionnaire. An objective recurrence was defined as a postoperative decline to stage II or below in any compartment based on the POP-Q system or the requirement for additional surgery. The assessment of postoperative subjective satisfaction was conducted using the Patient Global Impression of Improvement (PGI-I) score. Results: In total, 40 patients underwent sacrospinous ligament fixation. Objective recurrence was remarkably high, as it was observed in 17 (56.7%) patients. Subjective recurrence was reported by ten (33.3%) women, and reintervention occurred in two (6.7%) of patients. From the point of view of quality of life, according to the PGI-I, twenty-three (76.7%) patients described some degree of improvement after surgery, four (13.3%) described their status as unmodified, and three (10%) reported some form of worsening after primary treatment. Conclusions: Transvaginal repair with sacrospinous fixation is a long-lasting option for prolapse repair, with improvement in every POP-q parameter. Some degree of anterior recurrence, recurrence of symptoms with swelling, or an overall worsening of quality of life after surgery is possible.
Employing the Aviation Model to Reduce Errors in Robotic Gynecological Surgery: A Narrative Review
Authors: Restaino Stefano , Paparcura Federico , Arcieri Martina , Pellecchia Giulia , Poli Alice , Gallotta Valerio , Gueli Alletti Salvatore , Cianci Stefano , Capozzi Vito Andrea , Bogani Giorgio , Lucidi Alessandro , Klarić Marko , Driul Lorenza , Chiantera Vito , Dal Moro Fabrizio , Scambia Giovanni , Vizzielli Giuseppe
Published: August 2024

The operating room is the environment where harm to the patient is most likely. Robotic surgery was listed as one of the top 10 health hazards as late as 2020. Taking inspiration from other fields of application, such as aeronautics, checklists have been increasingly implemented in medical practice over the years, becoming essential components of the operating theatre. In addition to checklists, simulation has taken on a fundamental importance in reducing errors. This paper aims to provide a narrative review to assess the importance of checklists and training in robotic surgery and how they improve the outcome. A comprehensive literature search from January 2000 to September 2023 was conducted. A total of 97 articles were included in the initial search. Eleven studies were deemed relevant and were considered eligible for full-text reading. Among these, ten studies focused on the analysis of training effectiveness. An article in our review assessed the benefits of introducing checklists in the operating room. Innovations created in aviation, such as checklists and simulation, have entered the medical field to prevent human error. Developing dedicated checklist and surgical teams, through theoretical and practical training, has become essential in modern medicine. Tools such as checklists, training, and simulation are among the best methods to reduce adverse medical events.
Unpacking the Complexity of Corporate Sustainability: Green Innovation’s Mediating Role in Risk Management and Performance
Authors: Al-Nimer Munther
Published: August 2024

This study investigates the relationships among corporate sustainability development (CSD), enterprise risk management performance (ERMP), and green innovation (GI) in the Jordanian manufacturing firms. The empirical data of 97 companies listed on the Amman Stock Exchange were gathered in a time span of three months (i.e., January 2024 to March 2024). A structural equation modeling was employed to examine these complex dynamics. The findings reveal that CSD is negatively associated with both ERMP and enterprise sustainable performance in the short term, challenging conventional wisdom. However, CSD strongly promotes GI, which in turn positively influences ERMP while negatively affecting short-term performance. GI acts as a significant mediator, positively mediating the CSD–ERMP relationship and negatively mediating the CSD–performance link. These results extend the sustainability paradox concept to emerging economies and highlight the critical role of GI in balancing sustainability initiatives with risk management and performance outcomes. The study suggests that firms may experience initial disruptions when implementing sustainability practices, but these initiatives can drive innovation within organizations. Based on these findings, this study recommends that managers in emerging economies adopt a long-term perspective when implementing sustainability initiatives and develop more flexible risk management systems. Policymakers should consider supportive frameworks to help firms navigate the tensions between sustainability, innovation, and short-term performance. Future research should employ longitudinal designs to capture the dynamic nature of these relationships and explore potential moderating factors such as firm size or industry-specific characteristics.
The Determinants of Entrepreneurial Success: An Application to Micro-Enterprises Financed by Microcredit in France
Authors: Gandja Serge Valant , Kamaha Marinette
Published: August 2024

Micro-enterprises are at the heart of industrialized countries’ political concerns, particularly in Europe. If the latter are the subject of such special attention, it is because of their important role in terms of economic growth. This study evaluated the factors of business success as a multidimensional and multifaceted construct that integrates three aspects: entrepreneurial continuity, economic success, and entrepreneur satisfaction. Together, we included these three aspects in an econometric analysis using an ordered Probit model. We propose, from a new angle, an understanding of the determinants of the sustainable performance of micro-enterprises, in this case, those financed by microcredit in France. Our results show that total success seems to be explained in particular by elements from financial and human capital, motivation, and entrepreneurial support.
Lumbopelvic Stabilization with Two Methods of Triangular Osteosynthesis: A Biomechanical Study
Authors: Grüneweller Niklas , Leunig Julia , Zderic Ivan , Gueorguiev Boyko , Colcuc Christian , Wähnert Dirk , Vordemvenne Thomas
Published: August 2024

(1) Background: Pelvic fractures, and particularly instabilities of the dorsal pelvic ring, are becoming increasingly prevalent, particularly in orthogeriatric patients. Spino-pelvic triangular osteosynthesis is an effective approach to achieve sufficient stabilization in vertically unstable fractures. This study compares two types of osteosynthesis: the conventional one and a novel instrumentation where the iliosacral screw is placed through a fenestrated iliac screw. (2) Methods: Sixteen artificial osteoporotic L5+pelvis models with an unstable sacral fracture have been instrumented with either an iliac screw connected with a rod to a L5 pedicle screw and an iliosacral screw (TF) or a fenestrated ilium screw connected with a rod to a L5 pedicle screw and an iliosacral screw passing through the fenestra of the iliac screw (TFS). Biomechanical testing was performed using cyclic loading until failure. (3) Results: Both configurations yielded comparable results with regard to initial stiffness, implant loosening, and cycles to failure. The TFS exhibited markedly higher values for cycles to failure and markedly lower values for loosening. However, due to the characteristics of the artificial bone model, these findings were not significant. (4) Conclusions: The novel triangular fixation systems demonstrated comparable results to the standard triangular osteosynthesis configuration.
Prognostic Impacts of Age, Diagnosis Time, and Relapses in Primary CNS Lymphoma
Authors: Ohanyan Sona , Buxbaum Chen , Stein Polina , Ringelstein-Harlev Shimrit , Shelly Shahar
Published: August 2024

Background: The incidence of lymphomatous involvement of the central nervous system (CNS) has been increasing in recent years. However, the rarity of the disease has resulted in a scarcity of available data regarding its clinical presentation, natural history, and prognosis. We aimed to investigate the neurological characteristics of uncommon lymphomatous involvements confined to the CNS and to identify key variables that could serve as predictive biomarkers for treatment outcomes. Methods: We identified patients presenting with neurological symptoms and diagnosed with CNS-restricted lymphomatous involvement between 2005 and 2023. Results: We identified 44 cases, 93% of which were diagnosed with primary central nervous system lymphoma (PCNSL) and 7% with intravascular lymphoma. The median time from symptom onset to diagnosis was 47 days (range: 6–573 days), with no statistically significant difference between patients older and younger than 60 years (p = 0.22). The median follow-up time was 1144 days (range: 27–3501 days). Cognitive deterioration was the most common presenting symptom, occurring in 19 out of 44 patients (43%). Brain MRI revealed that lobar lesions were the most frequent location of lesions, found in 24 out of 44 patients (55%). By the end of the study period, 30 patients (68%) had died, with a median survival of 666 days (range: 17–3291 days). Death was significantly more common in patients who experienced relapses (p = 0.04; 95% CI: 0.99–0.03), with these patients having a four times higher chance of death (HR = 4.1; 95% CI: 1.01–16.09). The time to diagnosis significantly correlated with survival (p = 0.02; 95% CI: 0.005–0.54), as did the Eastern Cooperative Oncology Group (ECOG) performance status at the last follow-up (p = 0.006; 95% CI: 0.0012–0.62). Patients aged over 60 years did not exhibit a higher likelihood of death (p = 0.19; HR = 2.3; 95% CI: 0.63–8.61); however, the threshold age at diagnosis for the maximally predicted mortality was 64 years (ROC = 0.73; p = 0.03). Conclusions: Patients had significant delays in diagnosis, affecting patient outcomes. Cognitive deterioration and lobar lesions were prominent clinical and radiological features. Mortality was notably higher in patients with relapses and those who had a longer time to diagnosis.
Association of Microvasculature Changes with Visual Outcomes in Idiopathic Epiretinal Membrane Surgery: A Clinical Trial
Authors: Henry Marie , Ndiaye Ndeye Coumba , Angioi-Duprez Karine , Berrod Jean-Paul , Conart Jean-Baptiste
Published: August 2024

Purpose: The purpose of this paper is to evaluate macular microvascular changes and their correlation with visual outcomes after idiopathic epiretinal membrane (iERM) surgery. Methods: Forty-seven eyes operated for iERM were included in this retrospective case series. The foveal avascular zone (FAZ) area, and the vessel density (VD) in the superficial and the deep capillary plexus (SCP and DCP) were evaluated using optical coherence tomography angiography (OCTA). The association between the OCTA parameters and best-corrected visual acuity (BCVA) was examined preoperatively and postoperatively. Regression analyses were conducted to determine the potential predictive factors for visual recovery. Results: At baseline, the FAZ area in iERM eyes was significantly smaller than that in the control eyes (p < 0.001). iERM eyes also had a lower macular VD in both the SCP and the DCP (p < 0.001). Preoperative BCVA was negatively correlated with the FAZ area (r = −0.499, p < 0.001) and macular VD in the DCP (r = −0.422, p = 0.003). A negative correlation was also found between postoperative BCVA and macular VD in both the SCP (r = −0.394, p = 0.006) and the DCP (r = −0.569, p < 0.001). In the bivariate analyses, age, preoperative BCVA, iERM stage, and baseline macular VD in the SCP were significantly associated with BCVA at 6 months post-surgery. Multivariate regression analysis revealed that the preoperative BCVA was the only predictor of visual outcomes in iERM eyes (p < 0.001). Conclusions: Idiopathic epiretinal membrane (iERM) causes microvascular changes, including foveal avascular zone (FAZ) contraction and decreased macular vessel density (VD) in both the superficial capillary plexus (SCP) and the deep capillary plexus (DCP). These changes were significantly correlated with pre- and/or postoperative best-corrected visual acuity (BCVA). However, none of these alterations appeared to have prognostic value for visual outcomes in patients with iERM.
Insights into Probiotic Prescription among Gastroenterologists and Other Healthcare Professionals: Evidence from an Italian Survey
Authors: Marasco Giovanni , Bruni Angelo , Nardone Olga Maria , Lopetuso Loris Riccardo
Published: August 2024

Background: Probiotics, which are live microorganisms that provide health benefits, have been extensively studied for their various clinical applications. However, despite their potential, high-quality data supporting their use in several gastrointestinal diseases are often lacking, and prescription behaviors can widely differ. This study aimed to assess different behaviors in probiotics knowledge and prescriptions among Italian gastroenterologists and healthcare professionals (HPs). Methods: A web-based electronic survey was distributed to all participants at the National Meeting of the Italian Young Gastroenterologist and Endoscopist Association (AGGEI) held in 2023. The survey investigated probiotic prescription practices for several gastrointestinal conditions, such as acute diarrhea, irritable bowel syndrome, inflammatory bowel disease, and diverticular disease. Results: Among 200 participants, 142 completed the survey, of whom 59 were gastroenterologists and 83 were HPs (surgeons, nutrition biologists, and other physicians). Significant differences were observed in the prescription of probiotics for the treatment of acute diarrhea and H. pylori. Both groups prescribed probiotics in monthly cycles for patients with IBS, although the majority prescribed multistrain formulations. Gastroenterologists were more likely to prescribe cyclic courses for IBS, while HPs tended to continue therapy by changing the probiotic strain in case of inefficacy. For ulcerative colitis, gastroenterologists prescribed probiotics more but for shorter durations. In Crohn’s disease, gastroenterologists prescribed probiotics less and were less likely to prescribe multistrain formulations. Regarding SUDD, gastroenterologists tended to prescribe probiotics less frequently, although without a significant difference, with similar rates of preference for multistrain formulations. Conclusions: This survey highlights heterogeneous behaviors in probiotic prescription between gastroenterologists and HPs, with gastroenterologists more aligned with guidelines and available scientific evidence. Hence, enhancing probiotic education among healthcare professionals and gastroenterologists is crucial. Further studies are needed to better understand probiotics’ role in gastrointestinal disorders through large-scale randomized controlled trials.
Could Flow Cytometry Provide New Prognostic Markers in Colorectal Cancer?
Authors: Georvasili Vaia , Markopoulos Georgios , Lampri Evangeli , Lianos Georgios , Vartholomatos George , Mitsis Michail , Bali Christina
Published: August 2024

Background/Objectives: Colorectal cancer (CRC) is still accompanied by significant mortality, which poses the necessity of novel markers to predict treatment success and patient survival. This study aims to evaluate the prognostic and survival impact of flowytometry (FC) in CRC patients. Methods: In this prospective study, 106 surgically resectable CRC patients were included. Tissue specimens from tumor and normal mucosa were collected and analyzed by FC. DNA and tumor index were calculated. In a subgroup of 46 patients, the CD26 expression on tumor cells was estimated. These parameters were compared with patients’ tumor characteristics as stage, histology data, responsiveness to treatment, metastasis/recurrence, and, finally, patients’ survival to identify possible new biomarkers. Results: The overall survival and the disease-specific survival in our study group was 76% and 72%, respectively, during the 7-year follow up period. Diploid tumors had better median survival than the aneuploid ones. The DNA index had significant correlation to the tumor index and response to neoadjuvant treatment. Similarly, the tumor index was also significantly related to the response to neoadjuvant treatment. Patients with a higher tumor index had worst survival rates. Surprisingly, CD26 levels were not associated with any of the parameters examined and were negatively related to tumor stage and differentiation. Conclusions: FC is a rapid and reliable method of cell analysis. In CRC, it has been used for prognostic and diagnostic purposes. In this study, we have shown that DNA and tumor index could become predictive biomarkers of tumor response to neoadjuvant treatment and survival of resectable CRC patients.
Moving beyond Symptom Criteria to Diagnose and Treat Functional Disorders: Patient-Reported Symptoms of Functional Lower Gastrointestinal Disorders Correlate Poorly with Objective Assessment of Luminal Contents Seen on Intestinal Ultrasound
Authors: Brick Claudia , Su Heidi , Taylor Kirstin , Burgell Rebecca
Published: August 2024

Background/Objectives: The diagnosis of lower functional gastrointestinal disorders (FGIDs) is currently based on subjective and unreliable patient-reported symptoms, with significant clinical overlap between diagnosed phenotypes. Objective biomarkers are urgently sought. Gastrointestinal ultrasound (GIUS) can objectively and non-invasively assess luminal contents. This study aimed to assess the utility of GIUS in phenotyping patients with lower FGIDs. Methods: Patients with lower FGIDs underwent a GIUS and completed the Rome IV Diagnostic Questionnaire, SAGIS questionnaire, and 100 mm VAS score for overall symptom severity. The faecal loading score (FLS) was obtained using a modified Leech score, where an FLS of >37 was consistent with clinically significant constipation. Results: Eighty-eight patients fulfilled the study requirements. In total, 56 met the Rome IV criteria for irritable bowel syndrome (IBS) subtypes, while 23 met the criteria for functional constipation (FC), 4 for functional diarrhoea (FD), and 5 for other diagnoses. Patients reporting constipation-predominant symptoms had a significantly higher median FLS than those describing diarrhoea-predominant symptoms (FLS = 40 [IQR 20.0–53.3] vs. 13.3 [IQR 6.7–40.0], respectively). However, 27% of patients describing diarrhoea had significant faecal loading on GIUS, and of those who described constipation, 34% did not have significant faecal loading. Sensitivity and specificity for the detection of FLS-indicated constipation by the Rome IV criteria were low at 59% and 66%, respectively. Conclusions: The symptom-based diagnosis of FGID subtypes based on the Rome IV criteria is a poor predictor of faecal loading. These findings should prompt further exploration of the limitations of symptom-based assessment and a shift towards physiological assessment of patients with FGIDs such as gastrointestinal ultrasound to develop more targeted therapy. Future research is underway to determine if targeting objective physiological endpoints results in improved clinical outcomes.
The True Impact of Voiding Dysfunctions after Transobturator Sub-Urethral Tape Procedures: A Systematic Review of Literature
Authors: Plotti Francesco , Rampello Stefania , Terranova Corrado , De Cicco Nardone Carlo , Luvero Daniela , Montera Roberto , Di Donato Violante , Cavaliere Anna Franca , Campagna Giuseppe , Ficarola Fernando , Martinelli Arianna , Angioli Roberto
Published: August 2024

Introduction: Transobturator techniques are frequently used for the surgical treatment of female stress urinary incontinence (SUI), due to their high success rates and few intraoperative complications. However, controversial results have been reported in the literature regarding their incidence. The aim of this study is to analyze the real incidence and trend over time of such complications, especially voiding dysfunctions and overactive bladder (OAB) symptoms. Methods: A comprehensive search using PubMed/MEDLINE, Scopus, and Cochrane databases was performed. The search string used was the following: (female stress urinary incontinence) AND (complication) AND ((midurethral sling) OR (transobturator tape) OR (TVT-O) OR (voiding dysfunctions) OR (de novo OAB) OR (recurrent UTI) OR (vaginal erosion)). We included randomized controlled trials, prospective controlled studies, prospective and retrospective observational studies. All selected articles were screened based on titles and abstracts. Relevant data were extracted and tabulated. Results: A total of 39 studies were included in our analysis. Transobturator tape procedures show a high objective cure rate for SUI, from 76.9% to 100%. Postoperative voiding dysfunctions are shown to be quite common, ranging from 0–22% of cases. Despite that, this percentage decreases to 0–1% after 12 months. De novo OAB incidence ranges from 3% to 14% at 12 months, with variability over time due to multiple factors. Tape-related complications usually occur after 12 months, with a variable incidence up to 7%. Urinary tract infections (UTIs) are quite common in the immediate postoperative period but sometimes can be recurrent, requiring long-term prophylactic antibiotic treatment. Conclusions: Voiding dysfunctions are generally transient complications, while de novo OAB may persist over time. An adequate preoperative counseling, along with accurate written informed consent, could enhance patient tolerance of these issues and contribute to long-term patient satisfaction.
The Efficacy of Topical or Systemic Antibiotics as Adjuvants to Non-Surgical Periodontal Treatment in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: de Molon Rafael Scaf , Rodrigues Joao Victor Soares , Deroide Mariella Boaretti , da Silva Barbirato Davi , Garcia Valdir Gouveia , Theodoro Leticia Helena
Published: August 2024

Background: Periodontitis and diabetes mellitus (DM) exhibit a bidirectional relationship and are globally significant systemic chronic conditions. The utilization of antibiotics alongside non-surgical periodontal treatment (NSPT) has been a subject of investigation in numerous clinical studies involving human subjects. Thus, the objective of this systematic review is to address the following question: “What is the efficacy of scaling and root planing (SRP) associated with antimicrobials in patients with type 2 DM and periodontitis?”. Methods: A systematic review of the literature was conducted encompassing databases such as MEDLINE/PubMed, Scopus, and Web of Science up to July 2024. Additionally, alerts were configured to capture studies published from the initial search until manuscript submission. Randomized clinical trials assessing clinical periodontal parameters in DM patients undergoing SRP and receiving either topical or systemic antibiotics were compared against a control group (SRP only). Two investigators independently screened articles, extracted data, and evaluated their quality. The selection process, study characteristics, risk of bias, impact of antibiotics on clinical parameters, and certainty of evidence were elucidated in both textual and tabular formats. Meta-analysis was performed separately with forest plots generated for treatment modalities, period of evaluation, and type of antibiotics used. Results: Following the analysis of abstracts and full articles, a total of 30 randomized clinical trials were incorporated into this review, comprising 9 studies on the association of topical antibiotics and 21 studies on systemic antibiotic administration. The principal periodontal parameters assessed included probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), and bleeding on probing (BoP). Conclusions: Analysis of the results led to the conclusion that adjunctive periodontal treatment with either topical or systemic antibiotics confers subtle clinical benefits. Nevertheless, owing to the heightened emergence of resistant bacteria and potential side effects, the use of antibiotic therapy in periodontal treatment should be judiciously administered.
Buckling Analysis of Variable-Angle Tow Composite Plates through Variable Kinematics Hierarchical Models
Authors: Giunta Gaetano , Iannotta Domenico Andrea , Kirkayak Levent , Montemurro Marco
Published: August 2024

Variable-Angle Tow (VAT) laminates can improve straight fiber composites’ mechanical properties thanks to the application of curvilinear fibers. This characteristic allows one to achieve ambitious objectives for design and performance purposes. Nevertheless, the wider design space and the higher number of parameters result in a more complex structural problem. Among the various approaches that have been used for VAT study, Carrera’s Unified Formulation (CUF) allows one to obtain multiple theories within the same framework, guaranteeing a good compromise between the results’ accuracy and the computational cost. In this article, the linear buckling behavior of VAT laminates is analyzed through the extension of CUF 2D plate models within Reissner’s Mixed Variational Theorem (RMVT). The results show that RMVT can better approximate the prebuckling nonuniform stress field of the plate when compared to standard approaches, thus improving the prediction of the linear buckling loads of VAT composites.
Investigating Contrastive Pair Learning’s Frontiers in Supervised, Semisupervised, and Self-Supervised Learning
Authors: Sabiri Bihi , Khtira Amal , El Asri Bouchra , Rhanoui Maryem
Published: August 2024

In recent years, contrastive learning has been a highly favored method for self-supervised representation learning, which significantly improves the unsupervised training of deep image models. Self-supervised learning is a subset of unsupervised learning in which the learning process is supervised by creating pseudolabels from the data themselves. Using supervised final adjustments after unsupervised pretraining is one way to take the most valuable information from a vast collection of unlabeled data and teach from a small number of labeled instances. This study aims firstly to compare contrastive learning with other traditional learning models; secondly to demonstrate by experimental studies the superiority of contrastive learning during classification; thirdly to fine-tune performance using pretrained models and appropriate hyperparameter selection; and finally to address the challenge of using contrastive learning techniques to produce data representations with semantic meaning that are independent of irrelevant factors like position, lighting, and background. Relying on contrastive techniques, the model efficiently captures meaningful representations by discerning similarities and differences between modified copies of the same image. The proposed strategy, involving unsupervised pretraining followed by supervised fine-tuning, improves the robustness, accuracy, and knowledge extraction of deep image models. The results show that even with a modest 5% of data labeled, the semisupervised model achieves an accuracy of 57.72%. However, the use of supervised learning with a contrastive approach and careful hyperparameter tuning increases accuracy to 85.43%. Further adjustment of the hyperparameters resulted in an excellent accuracy of 88.70%.
A Multi-Scale Target Detection Method Using an Improved Faster Region Convolutional Neural Network Based on Enhanced Backbone and Optimized Mechanisms
Authors: Chen Qianyong , Li Mengshan , Lai Zhenghui , Zhu Jihong , Guan Lixin
Published: August 2024

Currently, existing deep learning methods exhibit many limitations in multi-target detection, such as low accuracy and high rates of false detection and missed detections. This paper proposes an improved Faster R-CNN algorithm, aiming to enhance the algorithm’s capability in detecting multi-scale targets. This algorithm has three improvements based on Faster R-CNN. Firstly, the new algorithm uses the ResNet101 network for feature extraction of the detection image, which achieves stronger feature extraction capabilities. Secondly, the new algorithm integrates Online Hard Example Mining (OHEM), Soft non-maximum suppression (Soft-NMS), and Distance Intersection Over Union (DIOU) modules, which improves the positive and negative sample imbalance and the problem of small targets being easily missed during model training. Finally, the Region Proposal Network (RPN) is simplified to achieve a faster detection speed and a lower miss rate. The multi-scale training (MST) strategy is also used to train the improved Faster R-CNN to achieve a balance between detection accuracy and efficiency. Compared to the other detection models, the improved Faster R-CNN demonstrates significant advantages in terms of mAP@0.5, F1-score, and Log average miss rate (LAMR). The model proposed in this paper provides valuable insights and inspiration for many fields, such as smart agriculture, medical diagnosis, and face recognition.
A Re-Appraisal of the Role of Monetary Policy: The Quantity Theory of Money through a Structural Vector Autoregressive Approach
Authors: Focacci Antonio , Focacci Angelo
Published: August 2024

The COVID-19 pandemic, the Russia–Ukraine and the Israel–Hamas conflicts, and the resulting global economic shocks will affect the world economy for several years. This paper analyzes and discusses monetary finance (MF) using the Quantity Theory of Money (QTM) to understand economic dynamics. To achieve this goal, we utilize a Structural Vector Autoregressive (SVAR) identification scheme with sign restrictions on datasets from advanced economies. The findings indicate that monetary growth plays a role in short-term inflationary dynamics, while its effects are less significant in the medium to long term. The aim of the paper is to contribute to ongoing debate surrounding the potential strategies for addressing the economic downturn through the reintroduction of monetary finance (MF).
Driving Forces behind the Reduction in Cropland Area on Hainan Island, China: Implications for Sustainable Agricultural Development
Authors: Guo Jianchao , Qi Shi , Chen Jiadong , Lai Jinlin
Published: August 2024

Food security is a major challenge for China at present and will be in the future. Revealing the spatiotemporal changes in cropland and identifying their driving forces would be helpful for decision-making to maintain grain supply and sustainable development. Hainan Island is endowed with rich agricultural resources due to its unique climatic conditions and is facing tremendous pressure in cropland protection due to the huge variation in natural conditions and human activities over the past few decades. The purpose of this study is to assess the spatiotemporal changes in and driving forces of cropland on Hainan Island in the past and predict future cropland changes under different scenarios. Key findings are as follows: (1) From 2000 to 2020, the cropland area on Hainan Island decreased by 956.22 km2, causing the center of cropland to shift southwestward by 8.20 km. This reduction mainly transformed into construction land and woodland, particularly evident in coastal areas. (2) Among anthropogenic factors, the increase in the human footprint is the primary reason for the decrease in cropland. Land use changes driven by population growth, especially in economically active and densely populated coastal areas, are key factors in this decrease. Natural factors such as topography and climate change also significantly impact cropland changes. (3) Future scenarios show significant differences in cropland area changes. In the natural development scenario, the cropland area is expected to continue decreasing to 597 km2, while in the ecological protection scenario, cropland conversion is restricted to 269.11 km2; however, in the cropland protection scenario, the trend of cropland reduction is reversed, increasing by 448.75 km2. Our findings provide a deep understanding of the driving forces behind cropland changes and, through future scenario analysis, demonstrate the potential changes in cropland area under different policy choices. These insights are crucial for formulating sound land management and agricultural policies to protect cropland resources, maintain food security, and promote ecological balance.