bluuebunny/crossref_metadata_2025 huggingface dataset:
Neoindustrialization—Reflections on a New Paradigmatic Approach for the Industry: A Scoping Review on Industry 5.0
Authors: Pereira Ricardo , dos Santos Neri
Published: July 2023

Background: The Industry 5.0 emerges as a new paradigm for the industry by considering sustainability, human-centered approaches, organizational resilience, and interaction between humans and machines as its core values. This new trend for the future of the industry is referred to as neoindustrialization. Due to being a topic in development, there is still no precise consensus on its definition, which prompted the current study to comprehensively investigate and analyze the existing literature on Industry 5.0. Methods: The method employed was a scoping review, examining publications from various databases and academic journals, including those specific to the Brazilian context. Results: The results indicate a transition towards an industry that meets societal demands and respects planetary boundaries, aspects that were overlooked by Industry 4.0. Conclusions: In this new scenario, the industry reassumes its leadership by combining technology with new strategies and organizational models. Furthermore, it undergoes organizational changes to align its structure, operations, human resources, and new practices, aiming to meet the demands of society and all stakeholders involved. To achieve this, it is necessary to create an environment conducive to innovation and entrepreneurship, promoting the development of qualified human capital, investments in research and development, and strengthening partnerships between the public and private sectors. A successful neoindustrialization policy will generate high-quality jobs and foster economic growth. Industry 5.0 is the paradigm that will prevail in the 21st century. It is not a matter of speculation; it is an inseparable and inevitable reality. Otherwise, the industry will be relegated to a secondary role in the process of digital and social transformation.
Investigating the Microscopic Mechanism of Ultrasonic-Vibration-Assisted-Pressing of WC-Co Powder by Simulation
Authors: Chen Yuhang , Wang Yun , Huang Lirong , Su Binbin , Yang Youwen
Published: July 2023

The ultrasonic-vibration-assisted pressing process can improve the fluidity and the uneven distribution of density and particle size of WC-Co powder. However, the microscopic mechanism of ultrasonic vibration on the powder remains unclear. In this paper, WC particles with diameter 5 μm and Co particles with diameter 1.2 μm were simulated by three-dimensional spherical models with the aid of the Python secondary development. At the same time, the forming process of the powder at the mesoscale is simulated by virtue of the finite element analysis software ABAQUS. In the simulation process, the vibration amplitude was set to 1, 2, and 3 μm. Their influence on the fluidity, the filling density, and the stress distribution of WC-Co powder when the ultrasonic vibration was applied to the conventional pressing process was investigated. The simulation results show that the ultrasonic vibration amplitude has a great influence on the density of the compact. With an increase in the ultrasonic amplitude, the compact density also increases gradually, and the residual stress in the billet decreases after the compaction. From the experimental results, the size distribution of the billet is more uniform, the elastic after-effect is reduced, the dimensional instability is improved, and the density curves obtained by experimentation and simulation are within a reasonable error range.
Influence of Strain Hardening Rate of Material on Temperature and Strain Distributions during Wire Drawing
Authors: Hwang Joong-Ki
Published: July 2023

Temperature rise of a specimen is a significant issue in drawing industries for wire, rod, and bar products, because an excessive increase in temperature during the drawing process can deteriorate the product quality and die life. The influence of the strain hardening exponent (n) of a wire on the temperature and strain distributions during wire drawing is investigated to understand its effect and to improve the quality of drawn wire. Finite element analysis and experiments are conducted to analyze the temperature and strain distributions of wires with n values of 0.0, 0.1, 0.5, and 1.0. The temperature increase of the wire augments as the n of the wire increases, despite the same amount of ideal plastic deformation, which is associated closely with the redundant work. The shear strain increases with the n of the specimen, which generates redundant work, leading to a high temperature rise. Similarly, drawing force increases with the n of the specimen, owing to the increase in redundant work with the n of the wire. In addition, the drawing force presents a linear relationship with the temperature rise of the wire. The drawing speed should be reduced and/or the cooling of wire and die should be strengthened during wire drawing, with increasing n value of the wire, because product quality and die wear are highly associated with the temperature rise of the wire in the deformation zone.
The Effect of the Microstructure Formed in the Forging–Healing Process on the Mechanical Properties of Heavy Forgings
Authors: Liu Qianjun , Qiu Yao , Xin Ruishan , Luo Jianbin , Ma Qingxian
Published: July 2023

The forging–healing of the internal porosity defects affects the tensile, impact and fatigue properties of heavy forgings. In the present work, the effect of deformation process on the microstructure in the joint area as well as the tensile strength, impact toughness and fatigue strength was studied experimentally. It is shown that the tensile strength is restored once the porosity defects were healed, and the impact toughness is recovered when the flat grain band is eliminated. The fatigue strength can be restored if a uniform grain structure can be achieved in both the joint area and the matrix, whereafter precipitate become the key factor affecting the fatigue strength. A complete healing of the porosity defects, a uniform grain structure in the joint area and the matrix, and a fully controlled precipitate are essential to guarantee the mechanical properties and in-service performance of the heavy forgings.
Safety and Effectiveness of Carbon Dioxide Removal CO2RESET Device in Critically Ill Patients
Authors: Taccone Fabio Silvio , Rinaldi Simone , Annoni Filippo , Nobile Leda , Di Nardo Matteo , Maccieri Jessica , Aliberti Anna , Malfertheiner Maximilan Valentin , Marudi Andrea , Broman Lars Mikael , Belliato Mirko
Published: July 2023

Background: In this retrospective study, we report the effectiveness and safety of a dedicated extracorporeal carbon dioxide removal (ECCO2R) device in critically ill patients. Methods: Adult patients on mechanical ventilation due to acute respiratory distress syndrome (ARDS) or decompensated chronic obstructive pulmonary disease (dCOPD), who were treated with a dedicated ECCO2R device (CO2RESET, Eurosets, Medolla, Italy) in case of hypercapnic acidemia, were included. Repeated measurements of CO2 removal (VCO2) at baseline and 1, 12, and 24 h after the initiation of therapy were recorded. Results: Over a three-year period, 11 patients received ECCO2R (median age 60 [43–72] years) 3 (2–39) days after ICU admission; nine patients had ARDS and two had dCOPD. Median baseline pH and PaCO2 levels were 7.27 (7.12–7.33) and 65 (50–84) mmHg, respectively. With a median ECCO2R blood flow of 800 (500–800) mL/min and maximum gas flow of 6 (2–14) L/min, the VCO2 at 12 h after ECCO2R initiation was 157 (58–183) mL/min. Tidal volume, respiratory rate, and driving pressure were significantly reduced over time. Few side effects were reported. Conclusions: In this study, a dedicated ECCO2R device provided a high VCO2 with a favorable risk profile.
Influence of the Straining Path during Cold Drawing on the Hydrogen Embrittlement of Prestressing Steel Wires
Authors: Toribio Jesús , Lorenzo Miguel
Published: July 2023

Cold drawing is a commonly used technique for manufacturing the prestressing steel wires used as structural elements in prestressed concrete structures. As a result of this manufacturing process, a non-uniform plastic strain and residual stress states are generated in the wire. These stress and strain fields play a relevant role as the main cause of the in-service failure of prestressing steel wires in the presence of an aggressive environment, hydrogen embrittlement (HE). In this paper, hydrogen susceptibility to HE is compared in two different commercial cold-drawn wires with the same dimensions at the beginning and at the end of manufacturing that follow different straining paths. To achieve this goal, numerical simulation with the finite element (FE) method is carried out for two different industrial cold-drawing chains. Later, the HE susceptibility of both prestressing steel wires was estimated in terms of the hydrogen accumulation given by FE numerical simulations of hydrogen diffusion assisted by stress and strain states, considering the previously obtained residual stress and plastic strain fields generated after each wire-drawing process. According to the obtained results, the hardening history modifies the residual stress and strain states in the wires, affecting their behavior in hydrogen environments.
Investigation of Laser-Welded Co-Cr Dental Alloys by Microscopy and Mechanical Testing
Authors: Carek Andreja , Slokar Benić Ljerka , Buković Dino , Šlaj Martina
Published: July 2023

In order to improve the hold and function of dentures for the patient, various prostheses made of metal, mostly metal alloys, are used every day in dental practise. Cobalt-chromium alloys are usually the first choice because they have very good mechanical properties and satisfactory clinical conditions. Nowadays, laser welding is increasingly used in dental practise due to its numerous advantages over other technologies. In this work, therefore, six commercially available Co-Cr alloys were investigated. Three of them are used for metal-ceramic work, two for denture frameworks and one is suitable for both applications. They were joined by laser welding and subsequently analysed microscopically. Their mechanical properties were determined and statistically evaluated. The microhardness of the laser-welded alloys is in the range of 282–465 MPa in the weld zone and between 283 and 435 MPa in the heat-affected zone. The flexural strength of the laser-welded alloys is lower than the control group, but an alloy for the metal-ceramic work (I-BOND NF) shows very similar value. Furthermore, this alloy, together with two other metal-ceramic alloys, survived a maximum of cycles in dynamic tests. It was found that the laser method can be used for joining Co-Cr alloys while ensuring appropriate parameters that guarantee the quality of the dental work.
Hydrogen-Induced Cracking in CGHAZ of Welded X80 Steel under Tension Load
Authors: Gou Jinxin , Xing Xiao , Cui Gan , Li Zili , Liu Jianguo , Deng Xiangyuan
Published: July 2023

X80 steel is extensively used in hydrogen environments and is susceptible to hydrogen embrittlement (HE). This paper studied the hydrogen-induced cracking (HIC) behavior in the coarse-grained heat-affected zone (CGHAZ) of X80 steel welds, through applying in situ hydrogen-charging tensile experiments, hydrogen permeation experiments, and various surface analysis techniques. It is shown that a few hydrogen atoms can significantly decrease a material’s elongation and reduction of area. When the heat input (HI) was 29.2 kJ/cm, the material had minor sensitivity to hydrogen embrittlement. The tensile fractures were ductile without hydrogen. However, the fracture surface exhibited brittle fracture with hydrogen. With increased HI, the HE fracture showed a transition of intergranular fracture→intergranular and transgranular mixed fracture→transgranular fracture. In the presence of hydrogen, the grain boundaries of elongated strips were prone to the formation of intergranular cracks under a tension load, and the hydrogen embrittlement resistance of the bulk lath bainite (LB) was weak. The hydrogen embrittlement susceptibility of pure granular bainite (GB) was lower. Fine LB and GB composite structures could remarkably inhibit intergranular cracks, giving the steel a superior resistance to hydrogen embrittlement.
Influence of Key Strata on the Evolution Law of Mining-Induced Stress in the Working Face under Deep and Large-Scale Mining
Authors: Xie Jianlin , Ning Shan , Zhu Weibing , Wang Xiaozhen , Hou Tao
Published: July 2023

When there are multiple key strata in the overburden of a deep coal seam and the surface subsidence coefficient after mining is small, this indicates that the overlying key strata fail to break completely after mining. On this occasion, stress is easily concentrated in the working face, which in turn leads to the occurrence of dynamic disasters such as rock bursts. This study adopted a comprehensive analysis method of field monitoring and numerical simulations to explore the influence of the key stratum on the evolution law of mining-induced stress in the working face. A distributed optical fiber sensor (DOFS) and a surface subsidence GNSS monitoring system were arranged inside and at the mouth of the ground observation borehole, respectively. According to the monitoring results of strain obtained from the DOFS, the height of the broken stratum inside the overlying strata was obtained and according to the monitoring results of surface subsidence, the surface subsidence coefficient was proven to be less than 0.1, indicating that the high key stratum is not broken completely, but enters a state of bending subsidence instead. In order to reveal the influence of the key stratum on the mining-induced stress of the working face, two 3DEC numerical models with and without the key stratum were established for a comparative analysis. As the numerical simulation results show, when there are multiple key strata in the overburden, the stress influence range and the stress concentration coefficient of the coal seam after mining are relatively large. The study revealed the working mechanism of rock burst accidents after large-scale mining and predicted the potential area with a rock burst risk after mining of the working face, which was verified by field investigations. The research results are of great guiding significance for the identification of the working mechanism of rock bursts in deep mining condition and for their prevention and control.
The Application of Portable X-ray Fluorescence (pXRF) for Elemental Analysis of Sediment Samples in the Laboratory and Its Influencing Factors
Authors: Zhou Shuguang , Wang Jinlin , Bai Yong , Wang Wei , Wang Shanshan
Published: July 2023

Several techniques, such as chemical methods and inductively coupled plasma mass spectrometry (ICP-MS), are available to accurately determine element content. However, they are time-consuming, labor-intensive, or expensive. Portable X-ray fluorescence spectrometry (pXRF) can be applied in various scenarios, with significantly higher efficiency and cost-effectiveness than laboratory methods. However, it also has limitations such as lower detection capability, relatively high detection limits, and lower accuracy than laboratory methods. In this study, we focused on applying pXRF to determine the elemental content of sediment samples and investigate its use in mineral exploration. A variety of factors influencing the results of pXRF analysis were analyzed. Our results showed that pXRF could detect more than 30 elements in stream sediments. The reliability of pXRF’s measurements was affected by factors such as the kind of element, sediment particle size, sample grinding treatment, count time, averaged element content, standard deviation of content, and range of content variation. The combination of pXRF analysis and laboratory analysis of partial samples is adequate for establishing a multi-element content inference equation. With this equation, it is possible to effectively infer the content gradient of elements, which will provide valuable support for mineral resource exploration.
Pesticide Residues in Mandarins: Three-Year Monitoring Results
Authors: Gormez Emrah , Golge Ozgur , González-Curbelo Miguel Ángel , Kabak Bulent
Published: July 2023

The demand of plant production product use has increased because of the current system of citrus production, which prioritizes high agricultural yields. Therefore, the monitoring of pesticide residues in citrus fruits and other agricultural products and their impacts on human health and food security are of great concern. This study aims to determine multi-class pesticides including highly polar residues in satsuma mandarins. A total of 226 mandarin samples were collected over three consecutive harvesting years from 2019 to 2021 in the Izmir region of Turkey. Targeted compounds included pesticides and metabolites with European Union (EU) regulatory levels, plus other non-approved residues and highly polar compounds. The residues excluding highly polar substances were analyzed by applying the quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction and liquid chromatography–triple quadrupole mass spectrometry (LC-MS/MS) determination for 434 analytes and gas chromatography–triple quadrupole mass spectrometry (GC-MS/MS) determination for 71 analytes. For six highly polar pesticides, sample preparation was based on Quick Polar Pesticides (QuPPe) extraction. The polar residues were determined by LC-MS/MS using internal standards. Forty different residues, including two highly polar substances, were recorded in mandarin samples through three harvesting years. In 8.4% of the samples, no quantifiable residues were detected, whereas 207 samples contained at least one residue. The maximum residue level (MRL) exceedances were recorded for 22.1% of the samples. The two most frequently found pesticides were phosphonic acid and spirotetramat, with an incidence rate of 48.7% and 46.5%, respectively. The concentration of phosphonic acid and spirotetramat in mandarin samples varied from 0.026 to 39.386 mg kg−1 and from 0.010 to 1.485 mg kg−1, respectively. The results will enable researchers and regulatory authorities to assess the extent of pesticide presence, identify potential risks, and take necessary measures to ensure the safety of satsuma mandarins for consumers.
Construction of N-Ferrocene Substituted Benzodihydrooxazoles via a Catalyst-Free Aza-Michael Addition/C(sp3)-O Bond Formation Tandem Reaction
Authors: Zhang Mingliang , Zhao Pin , Liu Qilv , Liu Xinlei , Hu Jingya , Wu Dongqing , Liu Lantao
Published: July 2023

A catalyst-free aza-Michael addition/C(sp3)-O bond formation tandem reaction of substituted amino ferrocenes with quinone esters was developed, which provided a green and efficient strategy for the construction of a C(sp3)-O bond from C(sp3)-H, and a series of N-ferrocene-substituted benzodihydrooxazoles were smoothly produced in moderate to excellent yields (up to >99% yield). The mechanism experiments showed that quinone esters performed as both substrate and oxidant. The salient features of this transformation include good functional group tolerance, broad substrate scope and mild conditions.
Determination of Flavonoid Compounds in Shanxi Aged Vinegars Based on Hydrophobic Deep Eutectic Solvent VALLME-HPLC Method: Assessment of the Environmental Impact of the Developed Method
Authors: Bai Baoqing , Guo Yanli , Meng Siyuan , Chen Shujun , Bo Tao , Zhang Jinhua , Shen Dan , Liu Yifei , Yang Yukun , Fan Sanhong
Published: July 2023

This research presents a novel, eco-friendly, vortex-assisted liquid–liquid microextraction (VALLME) approach, integrating hydrophobic deep eutectic solvents (DESs) with HPLC for the identification and quantification of nine specific flavonoids in Shanxi aged vinegar (SAV). The parameters of DES-VALLME, including the ratio of trioctylmethylammonium chloride to 1,4-butanediol (1:6), DES volume (150 μL), vortex duration (5 min), the concentration of NaCl (0.40 g), and centrifugation time (10 min), were optimized to achieve the maximum extraction efficiency of target substances. Under these optimal conditions, quantitative analyses performed via HPLC demonstrated a broad linear range of 0.20–50.00 μg/mL and correlation coefficients (r2) greater than 0.9944 for all nine calibration curves. The limits of detection (LOD) and limits of quantitation (LOQ) were 0.09–0.18 μg/mL and 0.30–0.60 μg/mL, respectively, ensuring high sensitivity. The relative standard deviations for intra-day and inter-day variability were within the acceptable range, 2.34–3.77% and 3.04–4.96%, respectively, demonstrating the method’s reliability. The recovery rates ranged from 85.97% to 108.11%, underscoring the method’s precision. This technique exhibited a significant enrichment effect (enrichment factor: 43 to 296) on SAV flavonoids. Notably, the eco-friendliness of this procedure was evaluated using the Analytical Eco-Scale, Green Analytical Procedure Index, and Analytical Greenness Metric. The results suggested that this technique is a viable green alternative to traditional flavonoid determination methods in SAV. In summary, this novel method provides a theoretical basis for assessing flavonoid content in SAV samples and tracing SAV products. This contribution has significant implications for enhancing analytical techniques in food chemistry and environmental science and the sustainable development of the food industry.
Oxygen Vacancy and Interface Effect Adjusted Hollow Dodecahedrons for Efficient Oxygen Evolution Reaction
Authors: Wang Huan , Ma Qian , Sun Fengmin , Shao Yachuan , Zhang Di , Sun Huilan , Li Zhaojin , Wang Qiujun , Qi Jian , Wang Bo
Published: July 2023

Metal–organic frameworks (MOFs) with special morphologies provide the geometric morphology and composition basis for the construction of platforms with excellent catalytic activity. In this work, cobalt–cerium composite oxide hollow dodecahedrons (Co/Cex-COHDs) with controllable morphology and tunable composition are successfully prepared via a high-temperature pyrolysis strategy using Co/Ce-MOFs as self-sacrificial templates. The construction of the hollow structure can expose a larger surface area to provide abundant active sites and pores to facilitate the diffusion of substances. The formation and optimization of phase interface between Co3O4 and CeO2 regulate the electronic structure of the catalytic site and form a fast channel favorable to electron transport, thereby enhancing the electrocatalytic oxygen evolution activity. Based on the above advantages, the optimized Co/Ce0.2-COHDs obtained an enhanced oxygen evolution reaction (OER) performance.
Mumefural Improves Recognition Memory and Alters ERK-CREB-BDNF Signaling in a Mouse Model of Chronic Cerebral Hypoperfusion
Authors: Kim Min-Soo , Kim Bu-Yeo , Kim Jung Im , Lee Joungbok , Jeon Won Kyung
Published: July 2023

Cognitive impairment resulting from chronic cerebral hypoperfusion (CCH) is known as vascular dementia (VaD) and is associated with cerebral atrophy and cholinergic deficiencies. Mumefural (MF), a bioactive compound found in a heated fruit of Prunus mume Sieb. et Zucc, was recently found to improve cognitive impairment in a rat CCH model. However, additional evidence is necessary to validate the efficacy of MF administration for treating VaD. Therefore, we evaluated MF effects in a mouse CCH model using unilateral common carotid artery occlusion (UCCAO). Mice were subjected to UCCAO or sham surgery and orally treated with MF daily for 8 weeks. Behavioral tests were used to investigate cognitive function and locomotor activity. Changes in body and brain weights were measured, and levels of hippocampal proteins (brain-derived neurotrophic factor (BDNF), extracellular signal-regulated kinase (ERK), cyclic AMP-response element-binding protein (CREB), and acetylcholinesterase (AChE)) were assessed. Additionally, proteomic analysis was conducted to examine the alterations in protein profiles induced by MF treatment. Our study showed that MF administration significantly improved cognitive deficits. Brain atrophy was attenuated and MF treatment reversed the increase in AChE levels. Furthermore, MF significantly upregulated p-ERK/ERK, p-CREB/CREB, and BDNF levels after UCCAO. Thus, MF treatment ameliorates CCH-induced cognitive impairment by regulating ERK/CREB/BDNF signaling, suggesting that MF is a therapeutic candidate for treating CCH.
Predictive Value of Malnutrition, Identified via Different Nutritional Screening or Assessment Tools, for Functional Outcomes in Patients with Stroke: A Systematic Review and Meta-Analysis
Authors: Liu Peiqi , Tian Huimin , Ji Tianliang , Zhong Tangsheng , Gao Lan , Chen Li
Published: July 2023

Background: Malnutrition affects more than half of patients with stroke. Although malnutrition leads to more deaths, a longer hospital stay, and higher costs, there is still a lack of consensus regarding the impact of malnutrition on physical functional outcomes in patients with stroke, and there are large differences in the diagnostic effects of nutritional screening or assessment tools for malnutrition. This study aimed to explore the impact of malnutrition in patients with stroke and assess the significance of current nutritional screening and assessment tools for these patients. Methods: Six databases were systematically searched until October 2022. Cohort studies meeting the eligibility criteria were included. Pooled effects were calculated using random-effects models. Results: Twenty-six studies with 21,115 participants were included. The pooled effects of malnutrition on poor functional outcome, FIM points, and dysphagia were OR = 2.72 (95% CI = 1.84–4.06), WMD = −19.42(95% CI = −32.87–−5.96), and OR = 2.80 (95% CI = 1.67–4.67), respectively. Conclusion: Malnutrition adversely affects the recovery of physical and swallowing functions in patients with stroke. Nutritional assessments consistently predict the outcomes of physical function in patients with stroke.
Yacon (Smallanthus sonchifolius) Flour Reduces Inflammation and Had No Effects on Oxidative Stress and Endotoxemia in Wistar Rats with Induced Colorectal Carcinogenesis
Authors: Grancieri Mariana , Viana Mirelle Lomar , de Oliveira Daniela Furtado , Vaz Tostes Maria das Graças , Costa Ignacchiti Mariana Drummond , Costa André Gustavo Vasconcelos , Brunoro Costa Neuza Maria
Published: July 2023

Colorectal cancer has a high worldwide incidence. The aim of this study was to determine the effect of yacon flour (YF) on oxidative stress, inflammation, and endotoxemia in rats with induced colorectal cancer (CRC). The Wistar male rats were divided and kept for 8 weeks in four groups: S (basal diet, n = 10), Y (YF flour + basal diet, n = 10), C (CRC-induced control + basal diet, n = 12), CY (CRC-induced animals + YF, n = 12). CRC was induced by intraperitoneal injections of 1,2-dimethylhydrazine (25 mg/kg body weight). Groups Y and CY received 7.5% of the prebiotic FOS from YF. The treatment with YF increased fecal secretory immunoglobulin A levels and decreased lipopolysaccharides, tumor necrosis factor alpha and interleukin-12. However, no effect was observed on the oxidative stress by the total antioxidant capacity of plasma, anion superoxide, and nitric oxide analysis of the animals (p < 0.05). The short-chain fatty acids acetate, propionate, and butyrate showed interactions with NF-κB, TLR4, iNOS, and NADPH oxidase by in silico analysis and had a correlation (by the Person analysis) with CRC markers. The yacon flour treatment reduced the inflammation in rats with induced CRC, and could be a promising food to reduce the damages caused by colorectal cancer.
Bispidine-Based Macrocycles: Achievements and Perspectives
Authors: Medved’ko Aleksei V. , Gaisen Savelii V. , Kalinin Mikhail A. , Vatsadze Sergey Z.
Published: July 2023

This review presents all currently known macroheterocyclic compounds that include a bispidine (3,7-diazabicyclo[3.3.1]nonane) fragment in their structure. A classification of bispidine-containing macroheterocycles, which is based on the ring size and the nature of bispidinic nitrogen atoms, is suggested. Synthetic approaches to the studied compounds are classified and considered. The features of the crystal structures and solution behavior of bispidine macroheterocycles are analyzed. Prospects for the development of these organic receptors are proposed.
Peptide Vaccines as Therapeutic and Prophylactic Agents for Female-Specific Cancers: The Current Landscape
Authors: Lekshmy Manju , Dhanya Chandrasekharan Rajalekshmi , Smrithi Jayashree SatheeshKumar , Sindhurani Janaki Anandavallyamma , Vandanamthadathil Jiji Joseph , Veettil Jayakrishnan Therthala , Anila Leelamma , Lathakumari Vishnu Sasidharan , Nayar Adhira M. , Madhavan Maya
Published: July 2023

Breast and gynecologic cancers are significant global threats to women’s health and those living with the disease require lifelong physical, financial, and social support from their families, healthcare providers, and society as a whole. Cancer vaccines offer a promising means of inducing long-lasting immune response against the disease. Among various types of cancer vaccines available, peptide vaccines offer an effective strategy to elicit specific anti-tumor immune responses. Peptide vaccines have been developed based on tumor associated antigens (TAAs) and tumor specific neoantigens which can also be of viral origin. Molecular alterations in HER2 and non-HER2 genes are established to be involved in the pathogenesis of female-specific cancers and hence were exploited for the development of peptide vaccines against these diseases, most of which are in the latter stages of clinical trials. However, prophylactic vaccines for viral induced cancers, especially those against Human Papillomavirus (HPV) infection are well established. This review discusses therapeutic and prophylactic approaches for various types of female-specific cancers such as breast cancer and gynecologic cancers with special emphasis on peptide vaccines. We also present a pipeline for the design and evaluation of a multiepitope peptide vaccine that can be active against female-specific cancers.
Liposomes for the Treatment of Brain Cancer—A Review
Authors: Raju Richu , Abuwatfa Waad H. , Pitt William G. , Husseini Ghaleb A.
Published: July 2023

Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consolidate relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes. The paper first briefly explains conventional treatment modalities for cancer, followed by describing the blood–brain barrier and ways, challenges, and techniques involved in transporting drugs across the BBB. Various nanocarrier systems are introduced, with attention to liposomes, due to their ability to circumvent the challenges imposed by the BBB. Relevant studies involving liposomal systems researched to treat brain tumors are reviewed in vitro, in vivo, and clinical studies. Finally, the challenges associated with the use of liposomes to treat brain tumors and how they can be addressed are presented.
Validating the Multi-Mode Model’s Ability to Reproduce Diverse Tokamak Scenarios
Authors: Rafiq Tariq , Wang Zibo , Morosohk Shira , Schuster Eugenio , Weiland Jan , Choi Wilkie , Kim Hyun-Tae
Published: July 2023

A large-scale validation exercise was conducted to assess the multi-mode model (MMM) anomalous transport model in the integrated modeling code TRANSP. The validation included 6 EAST discharges, 17 KSTAR discharges, 72 JET ITER-like wall D-D discharges, and 4 DIII-D fusion plasma discharges. Using the MMM, the study computed anomalous thermal, particle, impurity, and momentum transport within TRANSP. Simulations for EAST, KSTAR, and JET focused on electron and ion temperatures and safety factor profiles, while DIII-D simulations also considered electron density, toroidal rotation frequency, and flow shear. The predicted profiles were compared to experimental data at the diagnostic time, quantifying the comparison using root-mean-square (RMS) deviation and relative offsets. The study found an average RMS deviation of 9.3% for predicted electron temperature and 10.5% for ion temperature, falling within the experimental measurement error range 20%. The MMM model demonstrated computational efficiency and the ability to accurately reproduce a wide range of discharges, including various scenarios and plasma parameters, such as plasma density, gyroradius, collisionality, beta, safety factor and heating method variations.
Evaluation of the Effect of Digital Dentistry on the Accuracy of Implant Placement and Prosthesis Fabrication—A Systematic Review and Meta-Analysis
Authors: Reddy Naveen , Vempalli Swetha , Prakash Jayant , Suganna Mahesh , Meenakshi Srinivasa Iyer , Shivakumar Ganiga Channaiah , Crimi Salvatore , Minervini Giuseppe
Published: July 2023

Digital dentistry has gained significant attention in recent years due to its potential to improve the accuracy of implant placement and prosthesis fabrication. However, the literature on its effectiveness remains controversial, and a systematic review and meta-analysis are necessary to evaluate the available evidence. A comprehensive search was conducted across multiple online databases using MeSH keywords and Boolean operators. Data extraction was performed, and a bias assessment was conducted based on modified CONSORT guidelines. The pooled odds ratios (OR) and risk ratios (RR) and corresponding 95% confidence intervals (CI) were then calculated. Five studies met the inclusion criteria. The overall analysis showed no statistically significant difference in the accuracy of implant placement and prosthesis fabrication between digital and conventional techniques (OR: 0.95, 95% CI: 0.73 to 1.23 and RR: 0.95, 95% CI: 0.73 to 1.23). Subgroup analysis based on individual studies did not demonstrate consistent results. This review suggests that digital techniques do not significantly impact the accuracy of implant placement and prosthesis fabrication compared to conventional techniques in an in vitro setting. However, the overall evidence is limited by the small number of studies and the heterogeneity observed. Future well-designed studies, including randomized controlled trials and clinical studies, are needed to provide more robust evidence on the effectiveness of digital dentistry in clinical practice.
Multi-Center Validation of Pain Assessment in Advanced Dementia (PAINAD) Scale in Malaysia
Authors: Teh Hoon Lang , Tan In Jiann , Lim Hong Tak , Ho Yun Ying , Ng Chai Chen , Mohd Ali Rosmahani , Ling Jia Nee , Lim Wan Chieh , Pang Gordon Hwa Mang , Chua Hwee Hwee , Norizan Faisal , Ibrahim Norazlina , Goh Chin Eang , Chai Gin Wei , Suppamutharwyam Malarkodi , Ang Melinda , Musa Dyascynthia , Chan Soo Chin , Obet Nurulakmal , Yew Yan Xi , Yee Zhen Aun , Lee Ai Vuen , Ooi Way Ti , Ho Hee Kheen , Lee Yee Leng , Justa Rohilin , Lee Yoong Wah , Tay Hwei Wern , Teo Kuo Zhau , Makhtar Nor Hakima , Ungku Mohd Zam Ungku Ahmad Ameen
Published: July 2023

The detection of pain in persons with advanced dementia is challenging due to their inability to verbally articulate the pain they are experiencing. Pain Assessment in Advanced Dementia (PAINAD) is an observer-rated pain assessment tool developed based on non-verbal expressions of pain for persons with severe dementia. This study aimed to perform construct validation of PAINAD for pain assessment in persons with severe dementia in Malaysia. This was a prospective cross-sectional study conducted from 27 April 2022 to 28 October 2022 in eight public hospitals in Malaysia. The PAINAD scale was the index test, and the Discomfort Scale—Dementia of the Alzheimer Type (DS-DAT) and Nurse-Reported Pain Scale (NRPS) were the reference tests for construct and concurrent validity assessment. Pain assessment for the study subjects was performed by two raters concurrently at rest and during activity. The PAINAD score was determined by the first rater, whereas the DS-DAT and NRPS were assessed by the second rater, and they were blinded to each other’s findings to prevent bias. PAINAD showed good positive correlations ranging from 0.325 to 0.715 with DS-DAT and NRPS at rest and during activity, with a p-value of <0.05. It also demonstrated statistically significant differences when comparing pain scores at rest and during activity, pre- and post-intervention. In conclusion, the PAINAD scale is a reliable observer-rated pain assessment tool for persons with severe dementia in Malaysia. It is also sensitive to changes in the pain level during activity and at rest, pre- and post-intervention.
Stein’s Phenomenology of Grace
Authors: Lebech Mette
Published: July 2023

Stein’s Freedom and Grace (Freiheit und Gnade) phenomenologically describes the experience of grace as the desire, communication, or acceptance of God’s Spirit of Love, accessed in the act of faith motivated by the soul’s otherwise unfulfilled desire for self-mastery. This article first discusses the affordances of Stein’s phenomenology which equip her to see grace as a fulfilment of the natural life of the soul, which is experienced as coming from beyond itself. It then addresses how the individual, personal I fails to satisfy its implicit desire for rational and free action in the natural life of the soul and how, in contrast, its opposite, the graced, liberated life of the soul, allows it to, but not on its own, only through union with God’s Spirit. It proceeds from this existential alternative to show how the treatise unfolds as an investigation of the various a priori possibilities for grace to be experienced and why it makes sense to acknowledge faith as a legitimate source of knowledge, as Stein does in work postdating Freedom and Grace. Finally, it is argued that the treatise is phenomenological in nature and that it does not presuppose either metaphysics or Christian doctrine but instead contributes to underpinning both. This argument simultaneously explains Stein’s own subsequent engagement as a Christian philosopher.
Shame as an Ethical Category for an Integrative Diaconia in Brazil
Authors: von Sinner Rudolf
Published: July 2023

The growing political influence of evangélico Christians in traditionally Catholic Brazil has caught the attention of social and political scientists as well as theologians. Among others, the reasons for two-thirds of the mainly Pentecostal and Neo-Pentecostal electorate voting for Jair Messias Bolsonaro include a moral agenda concerning human sexuality and the “traditional family,” namely the rejection of abortion under any circumstance and same-sex marriage. This conservative agenda is shared in other countries and churches and shows as “traditionalist” (Benjamin Teitelbaum), especially in Brazil, the USA under Trump, and Russia. At the same time, other, more social aspects of Christian diaconia in caring for the integrity of the body are left aside, although they are foreseen in those churches’ declarations of faith and ethical catechisms. The 2019–2022 government’s blatant failure to cope with the COVID-19 pandemic, the appalling rise of hunger, and the destruction of the Amazon rainforest should give rise to what I call an “evangélico sense of shame” as a consequence of the incompatibility of many of the faith convictions of that part of the electorate with Bolsonaro’s stances and actions, retrieving shame as an ethical category. To this end, I analyze biblical notions and theological reflections on shame, as well as publications of evangélico churches with a focus on the largest of its churches in Brazil, the Assemblies of God. Thus, I intend to reclaim an integral diaconia for evangélico churches.
Measuring Vertical Urban Growth of Patna Urban Agglomeration Using Persistent Scatterer Interferometry SAR (PSInSAR) Remote Sensing
Authors: Prakash Aniket , Diksha  , Kumar Amit
Published: July 2023

In the present study, the vertical and horizontal growth of Patna Urban Agglomeration was evaluated using the Persistent Scatterer Interferometry Synthetic Aperture Radar (PSInSAR) technique during 2015–2018. The vertical urban growth assessment of the city landscape was assessed using microwave time series (30 temporal) datasets of Single Look Complex (SLC) Sentinel-1A interferometric Synthetic Aperture Radar using SARPROZ software (ver. 2020). This study demonstrated that peripheral city regions experienced higher vertical growth (~4 m year−1) compared to the city core regions, owing to higher urban development opportunities leading to significant land use alterations, the development of high-rise buildings, and infrastructural development. While the city core of Patna observed an infill and densification process, as it was already saturated and highly densified. The rapidly urbanizing city in the developing region witnessed a considerable horizontal urban expansion as estimated through the normalized difference index for built-up areas (NDIB) and speckle divergence (SD) using optical Sentinel 2A and microwave Sentinel-1A ground range detected (GRD) satellite data, respectively. The speckle divergence-based method exhibited high urban growth (net growth of 11.28 km2) with moderate urban infill during 2015–2018 and reported a higher accuracy as compared to NDIB. This study highlights the application of SAR remote sensing for precise urban area delineation and temporal monitoring of urban growth considering horizontal and vertical expansion through processing a long series of InSAR datasets that provide valuable information for informed decision-making and support the development of sustainable and resilient cities.
Improving the Accuracy of TanDEM-X Digital Elevation Model Using Least Squares Collocation Method
Authors: Shen Xingdong , Zhou Cui , Zhu Jianjun
Published: July 2023

The TanDEM-X Digital Elevation Model (DEM) is limited by the radar side-view imaging mode, which still has gaps and anomalies that directly affect the application potential of the data. Many methods have been used to improve the accuracy of TanDEM-X DEM, but these algorithms primarily focus on eliminating systematic errors trending over a large area in the DEM, rather than random errors. Therefore, this paper presents the least-squares collocation-based error correction algorithm (LSC-TXC) for TanDEM-X DEM, which effectively eliminates both systematic and random errors, to enhance the accuracy of TanDEM-X DEM. The experimental results demonstrate that TanDEM-X DEM corrected by the LSC-TXC algorithm reduces the root mean square error (RMSE) from 6.141 m to 3.851 m, resulting in a significant improvement in accuracy (by 37.3%). Compared to three conventional algorithms, namely Random Forest, Height Difference Fitting Neural Network and Back Propagation in Neural Network, the presented algorithm demonstrates a reduction in the RMSEs of the corrected TanDEM-X DEMs by 6.5%, 7.6%, and 18.1%, respectively. This algorithm provides an efficient tool for correcting DEMs such as TanDEM-X for a wide range of areas.
Construction, Spectral Modeling, Parameter Inversion-Based Calibration, and Application of an Echelle Spectrometer
Authors: Wang Yuming , Qu Youshan , Zhao Hui , Fan Xuewu
Published: July 2023

We have developed a compact, asymmetric three-channel echelle spectrometer with remarkable high-spectral resolution capabilities. In order to achieve the desired spectral resolution, we initially establish a theoretical spectral model based on the two-dimensional coordinates of spot positions corresponding to each wavelength. Next, we present an innovative and refined method for precisely calibrating echelle spectrometers through parameter inversion. Our analysis delves into the complexities of the nonlinear two-dimensional echelle spectrogram. We employ a variety of optimization techniques, such as grid exploration, simulated annealing, genetic algorithms, and genetic simulated annealing (GSA) algorithms, to accurately invert spectrogram parameters. Our proposed GSA algorithm synergistically integrates the strengths of global and local searches, thereby enhancing calibration accuracy. Compared to the conventional grid exploration method, GSA reduces the error function by 22.8%, convergence time by 2.16 times, and calibration accuracy by 7.05 times. Experimental validation involves calibrating a low-pressure mercury lamp, resulting in an average spectral accuracy error of 0.0257 nm after performing crucial parameter inversion. Furthermore, the echelle spectrometer undergoes a laser-induced breakdown spectroscopy experiment, demonstrating exceptional spectral resolution and sub-10 ns time-resolved capability. Overall, our research offers a comprehensive and efficient solution for constructing, modeling, calibrating, and applying echelle spectrometers, significantly enhancing calibration accuracy and efficiency. This work contributes to the advancement of spectrometry and opens up new possibilities for high-resolution spectral analysis across various research and industry domains.
Advancements in Triboelectric Nanogenerators (TENGs) for Intelligent Transportation Infrastructure: Enhancing Bridges, Highways, and Tunnels
Authors: Rayegani Arash , Matin Nazar Ali , Rashidi Maria
Published: July 2023

The development of triboelectric nanogenerators (TENGs) over time has resulted in considerable improvements to the efficiency, effectiveness, and sensitivity of self-powered sensing. Triboelectric nanogenerators have low restriction and high sensitivity while also having high efficiency. The vast majority of previous research has found that accidents on the road can be attributed to road conditions. For instance, extreme weather conditions, such as heavy winds or rain, can reduce the safety of the roads, while excessive temperatures might make it unpleasant to be behind the wheel. Air pollution also has a negative impact on visibility while driving. As a result, sensing road surroundings is the most important technical system that is used to evaluate a vehicle and make decisions. This paper discusses both monitoring driving behavior and self-powered sensors influenced by triboelectric nanogenerators (TENGs). It also considers energy harvesting and sustainability in smart road environments such as bridges, tunnels, and highways. Furthermore, the information gathered in this study can help readers enhance their knowledge concerning the advantages of employing these technologies for innovative uses of their powers.
Adaptive Control Method for Gait Detection and Classification Devices with Inertial Measurement Unit
Authors: Kim Hyeonjong , Kim Ji-Won , Ko Junghyuk
Published: July 2023

Cueing and feedback training can be effective in maintaining or improving gait in individuals with Parkinson’s disease. We previously designed a rehabilitation assist device that can detect and classify a user’s gait at only the swing phase of the gait cycle, for the ease of data processing. In this study, we analyzed the impact of various factors in a gait detection algorithm on the gait detection and classification rate (GDCR). We collected acceleration and angular velocity data from 25 participants (1 male and 24 females with an average age of 62 ± 6 years) using our device and analyzed the data using statistical methods. Based on these results, we developed an adaptive GDCR control algorithm using several equations and functions. We tested the algorithm under various virtual exercise scenarios using two control methods, based on acceleration and angular velocity, and found that the acceleration threshold was more effective in controlling the GDCR (average Spearman correlation −0.9996, p < 0.001) than the gyroscopic threshold. Our adaptive control algorithm was more effective in maintaining the target GDCR than the other algorithms (p < 0.001) with an average error of 0.10, while other tested methods showed average errors of 0.16 and 0.28. This algorithm has good scalability and can be adapted for future gait detection and classification applications.