bluuebunny/crossref_metadata_2025 huggingface dataset:
Man-in-the-Loop Control and Mission Planning for Unmanned Underwater Vehicles
Authors: Han Mengxue , Wang Jialun , Yuan Jianya , Wang Zhao , Yu Dan , Zhang Qianqian , Wang Hongjian
Published: February 2024

UUVs (unmanned underwater vehicles) perform tasks in the marine environment under direction from a commander through a mother ship control system. In cases where communication is available, a UUV task re-planning system was designed to ensure task completion despite uncertain events faced by UUVs. First, the XML language standardizes the expression of UUV task elements. Second, considering the time sequence and spatial path planning requirements of human-supervised UUV control tasks, time sequence planning based on a genetic algorithm and spatial path planning based on an improved genetic algorithm were designed to plan near-optimal approximate spatial paths for control tasks. Third, uncertainties encountered during UUV task execution were classified so that the commander could adjust according to the situation or invoke the control task re-planning algorithm to re-plan. Finally, a simulation platform was built using the QT development environment to simulate human-supervised UUV control task planning and re-planning, verifying the algorithm’s design effectiveness.
An Equivalent Linear Method to Predict Nonlinear Bending Mechanics of Dredging Floating Hose String
Authors: Liu Jingjing , Yu Long , Li Xiaoyan , Liu Jing
Published: February 2024

Dredging hoses are flexible and are particularly suitable for slurry transportations for mud or sand in dredging projects. To achieve sufficient bending stiffness and to prevent the pipe body from collapsing, this type of hose segment is a composite structure that is embedded with several cord reinforcement layers and steel wires in its rubber layer. To quickly evaluate the nonlinear bending mechanical properties of rubber hoses, this study proposes the equivalent stiffness method of linear superposition, which is verified by test data and numerical results. The results show that the equivalent bending stiffness method proposed in this study is in good agreement with numerical and experimental results. Then, by comparing the calculation results of the hose string, it was demonstrated that the linear stiffness superposition method proposed in this study can also accurately predict the bending mechanical behavior characteristics of string hose, and provide reliable guidance for hose design in practice.
Installation Disturbance of Helical Anchor in Dense Sand and the Effect on Uplift Capacity Based on Discrete Element Method
Authors: Chen Rong , Liu Hu , Hao Dongxue , Liu Zhaoguo , Yuan Chi
Published: February 2024

Helical anchors have been extensively employed as foundation systems for carrying tension loads due to their installation efficiency and large uplift capacity. However, the installation influences of helical anchors are still not well understood, especially for multi-helical anchors. The matrix discrete element method was used to model the process of helical anchor penetration and pull-out in dense sand to investigate the effects of the anchor geometry and advancement ratio (AR, the relative vertical movement per rotation) on soil disturbance, the particle flow mechanism, and the uplift capacity. For shallow helical anchors, the overall disturbance zone is the shape of an inverted cone after installation, while for deep helical anchors, it is funnel-shaped. The advancement ratio has significant effects on the soil particle movement and uplift capacity of helical anchors. The soil particle flow mechanism around helical plates has been identified for single-helix anchors at various advancement ratios, and for double-helix anchors, the influence of the top plate on particle movement during installation was investigated. The uplift capacities of both single- and double-helix anchors increase with the decrease in the AR (AR = 0.5~1), and the influence decreases with the anchor embedment ratio. The efficiency of double-helix anchors induced by installation is close to 1 at pitch-matched installation (AR = 1), indicating that the impact of the top plate during installation is minimal in this case.
Review on the Application of Artificial Intelligence Methods in the Control and Design of Offshore Wind Power Systems
Authors: Song Dongran , Shen Guoyang , Huang Chaoneng , Huang Qian , Yang Jian , Dong Mi , Joo Young Hoon , Duić Neven
Published: February 2024

As global energy crises and climate change intensify, offshore wind energy, as a renewable energy source, is given more attention globally. The wind power generation system is fundamental in harnessing offshore wind energy, where the control and design significantly influence the power production performance and the production cost. As the scale of the wind power generation system expands, traditional methods are time-consuming and struggle to keep pace with the rapid development in wind power generation systems. In recent years, artificial intelligence technology has significantly increased in the research field of control and design of offshore wind power systems. In this paper, 135 highly relevant publications from mainstream databases are reviewed and systematically analyzed. On this basis, control problems for offshore wind power systems focus on wind turbine control and wind farm wake control, and design problems focus on wind turbine selection, layout optimization, and collection system design. For each field, the application of artificial intelligence technologies such as fuzzy logic, heuristic algorithms, deep learning, and reinforcement learning is comprehensively analyzed from the perspective of performing optimization. Finally, this report summarizes the status of current development in artificial intelligence technology concerning the control and design research of offshore wind power systems, and proposes potential future research trends and opportunities.
Comparative Transcriptome Profiles of the Response of Mycelia of the Genus Morchella to Temperature Stress: An Examination of Potential Resistance Mechanisms
Authors: Yue Yihong , Hao Haibo , Wang Qian , Xiao Tingting , Zhang Yuchen , Chen Hui , Zhang Jinjing
Published: February 2024

Temperature and moisture belong to the most important environmental factors affecting the growth and development of fungi. However, the effect of temperature on the mycelia of the edible Morchella mushrooms has not been determined. Here, a comprehensive analysis was performed to determine the influence of culture temperature on 13 strains of mycelia of three Morchella species (Morchella sextelata, Morchella septimelata, and Morchella importuna) at 5 °C, 10 °C, 15 °C, 20 °C, 25 °C, and 30 °C. The mycelial branching and growth rate data showed that 15–20 °C was a suitable temperature range for the mycelial growth of the 13 Morchella strains. RNA sequences revealed that a total of 2843, 2404, 1973, 1572, and 1866 differentially expressed genes (DEGs) were identified at 5 °C, 10 °C, 15 °C, 25 °C, and 30 °C compared with 20 °C. A Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis further indicated that the purine nucleotide and tyrosine metabolism pathways were crucial for mycelium development. Moreover, the enrichment of autophagy of mitochondria, regulation of cell morphogenesis, and piecemeal microautophagy of the nuclei at 25 °C (vs. 20 °C) indicated the damage caused by heat stress in Morchella mycelia. Notably, a total of four unique module eigengenes (MEs) were identified through a weighted gene coexpression network analysis (WGCNA). Among them, 2293 genes in the turquoise module were significantly positively correlated with temperature (r = 0.946, p < 0.001), whereas 739 genes in the blue module were significantly negatively correlated with temperature (r = −0.896, p < 0.001), suggesting that the effect of high temperatures on mycelial genes was significantly greater than that of low temperatures. Moreover, the coexpression network indicated that high culture temperatures accelerated the oxidative stress response and energy metabolism in mycelia, while upregulation of purine nucleotide catabolism and ribosomal protein-related genes were improved by low-temperature tolerance. In addition, the upregulated expression of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and heat shock protein (HSP) genes in mycelia was associated with reactive oxygen species (ROS)-mediated damage at high temperatures. Overall, this study provides an important theoretical basis and application value for optimizing Morchella cultivation techniques.
A Blow-Up Criterion for 3D Compressible Isentropic Magnetohydrodynamic Equations with Vacuum
Authors: Wang Shujuan , Ren Jialin , Su Rijian
Published: February 2024

In this paper, we investigate a blow-up criterion for compressible magnetohydrodynamic equations. It is shown that if density and velocity satisfy (∥ρ∥L∞(0,T;L∞)+∥u∥C([0,T];L3)<∞), then the strong solutions to isentropic magnetohydrodynamic equations can exist globally over [0,T]. Notably, our analysis accommodates the presence of an initial vacuum.
Comparative Meta-Analysis of Minimally Invasive and Conventional Approaches for Caries Removal in Permanent Dentition
Authors: González-Gil Diego , Flores-Fraile Javier , Vera-Rodríguez Vicente , Martín-Vacas Andrea , López-Marcos Joaquín
Published: February 2024

Background and Objectives: Addressing deep carious lesions poses significant challenges in daily dental practice due to the inherent complexity of their treatment. Traditionally, complete removal of carious tissues has been the norm, potentially leading to pulp tissue exposure and subsequent pulpitis. In contemporary dentistry, there is a growing preference for minimally invasive techniques, such as selective removal, offering a more conservative approach with enhanced predictability and success rates. Materials and Methods: Our study commenced with a comprehensive systematic review. After that, we performed a meta-analysis focused exclusively on randomized controlled trials involving permanent dentition. Our investigation incorporated seven selected articles, which scrutinized success rates and the incidence of pulp exposure in minimally invasive techniques (MIT) versus conventional techniques (CT). Statistical analysis employed U Mann–Whitney and Wilcoxon tests to interpret the results. Results: Although the difference did not reach statistical significance, MIT demonstrated marginally superior success rates compared to CT. Furthermore, MIT exhibited a lower percentage of pulp exposure when contrasted with CT. However, due to the limited sample size, statistical significance for this difference could not be established. Conclusions: Minimally invasive techniques for caries removal emerge as a conservative and promising approach to safeguard pulp tissues in comparison to conventional techniques. The need for additional randomized controlled trials is emphasized to unequivocally establish the superior success rates of these procedures over their conventional counterparts.
Assessment of Preoperative Anxiety and Influencing Factors in Patients Undergoing Elective Surgery: An Observational Cross-Sectional Study
Authors: Oh Juseok , Lee Wonjin , Ki Seunghee , Suh Jaewoo , Hwang Seokwoo , Lee Jeonghan
Published: February 2024

Background and Objectives: Preoperative anxiety is a common emotional response before elective surgery that influences postoperative outcomes and can increase analgesic requirements. However, clinicians frequently overlook these concerns. This study aimed to quantify preoperative anxiety and evaluate its association with patient-related factors. Materials and Methods: Anxiety levels were evaluated in adult patients awaiting elective surgery using the Korean-translated version of the Amsterdam Preoperative Anxiety and Information Scale (APAIS) and the State-Trait Anxiety Inventory-Korean YZ form (STAI-KYZ). The patients were also surveyed regarding the subjective causes of preoperative anxiety. Results: The study found that a total of 55 adult patients had a well-balanced subject distribution. Both questionnaires showed high internal consistency (Cronbach’s alpha values of 0.85 and 0.93). Significant correlations were observed in situational anxiety scores from the questionnaires, indicating differences between groups with high trait anxiety and those with normal anxiety levels (p < 0.05). Notably, female sex was the only patient-related factor that significantly affected the anxiety scores (p < 0.05). Furthermore, when considering additional patient factors stratified by sex, it became evident that younger females and females with prior general anesthesia experience displayed higher anxiety levels than their male counterparts. The most commonly reported subjective concern related to anesthesia was the fear of not regaining consciousness, followed by concerns about postoperative pain, intraoperative emergence, and other issues. Conclusions: This study confirms that being female is a significant risk factor for preoperative anxiety. Therefore, it is necessary to provide enhanced preoperative anxiolytic therapies, including preoperative patient education and other interventions, to individuals undergoing surgical procedures.
A Three-Arm Randomized Controlled Trial of Primary One-Anastomosis Gastric Bypass: With FundoRing or Nissen Fundoplications vs. without Fundoplication for the Treatment of Obesity and Gastroesophageal Reflux Disease
Authors: Ospanov Oral , Zharov Nurlan , Yelembayev Bakhtiyar , Duysenov Galymjan , Volchkova Irina , Sultanov Kassymkhan , Mustafin Adil
Published: February 2024

Background and Objectives: Obesity and gastroesophageal reflux disease (GERD) are steadily increasing world weight and antireflux surgery must be performed simultaneously with bariatric surgery in obese patients. The purpose of this study is to compare bariatric and antireflux results after OAGB with different methods of fundoplication using the excluded stomach and without fundoplication. Materials and methods: This open-label, randomized, parallel three-arm trial was conducted from March 2019 and December 2021. All patients underwent laparoscopic one-anastomosis gastric bypass and suture cruroplasty, and then had a follow-up at 24 months. Group 1 of patients had fundoplication FundoRing using the excluded stomach (FundoRingOAGB); Group 2, with Nissen fundoplication using the excluded stomach (NissenOAGB); and Group 3, without fundoplication (OAGB). We studied changes in BMI, GERD symptoms (GERD-HRQL), and the VISICK score. Results: Of 219 participants screened, 150 were randomly allocated to 3 groups: FundoRingOAGB group (n = 50), NissenOAGB group (n = 50), and OAGB group (n = 50). At post-treatment month 24, BMI changes were as follows: from 40.7 ± 5.9 (31–53) to 24.3 ± 2.8 (19–29) kg/m2 in FundoRingOAGB group; from 39.9 ± 5.3 (32–54) to 26.3 ± 2.9 (23–32) kg/m2 in Nissen group; and from 40.9 ± 6.2 (32–56) to 28.5 ± 3.9 (25–34) kg/m2 in OAGB group. The mean pre-operative GERD-HRQL heartburn score improved post-op in FundoRingOAGB group from 20.6 ± 2.24 (19.96, 21.23) to 0.44 ± 0.73 (0.23, 0,64); in NissenOAGB group from 21.34 ± 2.43 (20.64, 22.03) to 1.14 ± 1.4 (0.74, 1.53); and in OAGB group 20.5 ± 2.17 (19.9, 21.25) to 2.12 ± 1.36 (1.73, 2.5). GERD-HRQL total scores were from pre-op 25.2 ± 2.7 (24.4, 25.9) to 4.34 ± 1.3 (3.96, 4.7) post-op in FundoRingOAGB group; 24.8 ± 2.93 (24, 25.67) pre-op to 5.42 ± 1.7 (4.9, 5.9) in the NissenOAGB group; and from 21.46 ± 2.7 (20.7, 22.2) to 7.44 ± 2.7 (6.6, 8.2) in the OAGB group. The mean VISICK score improved from 3.64 ± 0.94 (3.7, 3.9) to 1.48 ± 1.26 (1.12, 1.84) in FundoRingOAGB, from 3.42 ± 0.97 (3.1, 3,7) to 2.5 ± 1.46 (2.06, 2.9) in NissenOAGB group and from 3.38 ± 0.88 (3.1, 3,69) to 2.96 ± 1.19 (2.62, 3.2) in OAGB group. Conclusions: Antireflux and bariatric results of FundoRingOAGB are better than using the NissenOAGB method and significantly better than OAGB without the use of fundoplication.
Nanomedicine-Based Drug Delivery Systems and the Treatment of Autism Spectrum Disorders: A Review
Authors: Jean-Baptiste Zaria , Pathak Yashwant , Sneed Kevin B.
Published: February 2024

Nanotechnology has played a pioneering role in advancing medical applications, aiming to enhance healthcare through innovation and collaboration. Nanomedicine can be seen expanding into many fields from cancer therapies, cosmetics, tissue regeneration, biosensing, and infectious diseases, and now, it is seen venturing into the realm of research geared toward autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder characterized by restrictive, monotonous activities or fixed interests as well as difficulties with social communication. As of now, there are no validated quantitative metrics for diagnosing autism, nor is there a drug that is specifically designed to treat the condition. As identifiers of ASD have improved, the diagnosis of individuals who meet established criteria have dramatically increased over the years. Although there is still no recognized nanomedicine treatment specifically intended for ASD, research is looking into how nanotechnology might be used in a number of ASD-related areas. This comprehensive review examines prior research efforts aimed at preventing, treating, and diagnosing individuals with ASD. It particularly focuses on the significance of prenatal care and investigates advancements in drug delivery methods through the blood–brain barrier concerning ASD treatment and management.
Exploring Plant Extracts as a Novel Frontier in Antimicrobial Innovation: Plant Extracts and Antimicrobials
Authors: Venanzoni Roberto , Flores Giancarlo Angeles , Angelini Paola
Published: February 2024

The scientific exploration presented in this Special Issue offers a comprehensive overview of recent advancements in the realm of plant-derived antimicrobials [...]
Gut Microbiome–Colorectal Cancer Relationship
Authors: Yadav Devvrat , Sainatham Chiranjeevi , Filippov Evgenii , Kanagala Sai Gautham , Ishaq Syed Murtaza , Jayakrishnan Thejus
Published: February 2024

Traditionally, the role of gut dysbiosis was thought to be limited to pathologies like Clostridioides difficile infection, but studies have shown its role in other intestinal and extraintestinal pathologies. Similarly, recent studies have surfaced showing the strong potential role of the gut microbiome in colorectal cancer, which was traditionally attributed mainly to sporadic or germline mutations. Given that it is the third most common cancer and the second most common cause of cancer-related mortality, 78 grants totaling more than USD 28 million have been granted to improve colon cancer management since 2019. Concerted efforts by several of these studies have identified specific bacterial consortia inducing a proinflammatory environment and promoting genotoxin production, causing the induction or progression of colorectal cancer. In addition, changes in the gut microbiome have also been shown to alter the response to cancer chemotherapy and immunotherapy, thus changing cancer prognosis. Certain bacteria have been identified as biomarkers to predict the efficacy of antineoplastic medications. Given these discoveries, efforts have been made to alter the gut microbiome to promote a favorable diversity to improve cancer progression and the response to therapy. In this review, we expand on the gut microbiome, its association with colorectal cancer, and antineoplastic medications. We also discuss the evolving paradigm of fecal microbiota transplantation in the context of colorectal cancer management.
A New Perspective on the Applicability of Diffuse Reflectance Spectroscopy for Determining the Hematite Content of Fe-Rich Soils in the Tropical Margins of China
Authors: Li Jiawei , Lü Bin , Chen Tianyuan , Liu Xin , Tang Jinmeng , Yan Hui
Published: February 2024

Hematite and goethite are widely occurring chromogenic iron oxides in soils and sediments that are sensitive to climatic dry/wet shifts. However, only by accurately quantifying the content or ratio of hematite and goethite can they be applied reliably to palaeoclimate reconstruction. Compared to the Loess Plateau of China, hematite in the soils of southern China has not been sufficiently studied. We used diffuse reflectance spectroscopy (abbreviation DRS, including the first-derivative curves and the second-derivative curves of the Kubelka–Munk remission functions), combined with ignition at 950 °C, and X-ray fluorescence (XRF) to quantify the hematite content of four tropical-margin iron-rich soil profiles with different matrix compositions in the Leizhou Peninsula, China. We also examined the application of hematite quantification parameters in soils with different matrix compositions under the same climatic conditions. Our main findings are as follows: (i) DRS first-derivative curves can reflect the presence of goethite and hematite in soils, and their relative contents can be compared within the same profile. (ii) The second-derivative curve of the Kubelka–Munk remission functions can reflect the relative proportions of goethite and hematite and provide information about the degree of Al substitution. (iii) Combined with calibration equations, soil redness can reliably quantify the hematite content, but it is necessary to consider the effect of mucilage envelopes in the process of hematite formation. Additionally, we summarize various methods used for quantifying hematite, and the influence of soil matrix compositions, with the aim of providing a reference for hematite quantification elsewhere. We also propose a new indicator (ΔHmRed/HmRed) to help detect iron hydroxide/iron oxide changes in soils.
Effects of Non-Saccharomyces Yeasts and Their Pairwise Combinations in Co-Fermentation with Saccharomyces cerevisiae on the Quality of Chunjian Citrus Wine
Authors: Fu Yu , Gao Yueyue , Yang Ming , Chen Juan , Zhu Chenglin , Tang Junni , Chen Lianhong , Cai Zijian
Published: February 2024

Non-Saccharomyces (NSc) yeasts have great potential in improving wine qualities. In this study, two NSc and two Saccharomyces cerevisiae (Sc) samples were tested on their performance of mono-inoculated and composite culture in the fermentation of Chunjian citrus wine. The cell count, Brix degree, total sugar, total acidity, alcohol level, pH value, color intensity (CI), and tonality were determined to evaluate the contribution of NSc to the quality of citrus wine in the mixed fermentation. Volatile compounds were analyzed by HS-SPME-GC-MS, and sensory evaluation was carried out. During the 9-day fermentation, the mixed-culture wine exhibited a higher cell concentration than the pure culture. After the fermentation, mixed-culture wine specifically decreased the concentrations of unfavorable volatile compounds, such as isobutanol and octanoic acid, and increased favorable volatile compounds, including ethyl octanoate, ethyl decanoate, and phenylethyl acetate. The quality category of the citrus wine was improved compared with the Sc mono-inoculated wines, mainly in regard to aroma, retention, and sweetness. The study shows that the mixed fermentation of NSc and Sc has positive impacts on reducing alcohol level and total acidity and increasing CI. The present work demonstrates that the mixed fermentation of NSc and Sc has enormous beneficial impacts on improving the quality of citrus wine.
Breastfeeding Practices for COVID-19-Infected Mothers: A Systematic Review and Meta-Analysis
Authors: Boukoura Maria Eleni , Dagla Maria , Gourounti Kleanthi , Nieri Alexandra Stavroula , Taskou Chrysoula , Tsoukala Eleni , Sarantaki Antigoni
Published: February 2024

(1) Background: The ongoing COVID-19 pandemic has led to an increasing number of women giving birth while also grappling with SARS-CoV-2. The objective of this review is to examine the possibility of transmission of the virus from mother to infant through breastfeeding, skin-to-skin contact, and rooming-in and to explore methods for managing COVID-19-positive mother–infant dyads. (2) Methods: A comprehensive search strategy was employed that covered pertinent studies from the Cochrane Library, PubMed Central, and Scopus databases. The Matrix Method and PRISMA guidelines were utilized by the researchers, with the search being updated until 20 December 2021, one year after the initial vaccine delivery. The inclusion criteria for the study involved articles published in English, those employing broad search terms, and those comprising full-text reviews. Additionally, the researchers required that the articles be published from December 2019 onwards. To further analyze the data, a meta-analysis was performed to estimate the rate of infant infection from mothers who engaged in breastfeeding, skin-to-skin contact, and rooming-in practices. (3) Results: Eighteen studies were analyzed in this review, with an infected infant rate of 2.8%. The maternal practices used in these studies ranged from direct separation of the infant to direct skin-to-skin contact, rooming-in, and exclusive breastfeeding. One study investigated the factors associated with positive test results in newborns and found that only the maternal social vulnerability index >90 was a significant predictor. The type of delivery, rooming-in, and the mother’s symptom status were not associated with positive neonatal outcomes. (4) Conclusions: According to current data, the incidence of perinatal infection with SARS-CoV-2 is relatively low. It is advised that mothers adhere to several supportive care measures, including engaging in breastfeeding, skin-to-skin contact, and rooming-in. These measures ought to be complemented by diligent hand hygiene, the wearing of masks, and the cleansing of breasts solely when necessary.
A New Look at b → s Observables in 331 Models
Authors: Loparco Francesco
Published: February 2024

Flavour changing neutral current (FCNC) processes are described by loop diagrams in the Standard Model (SM), while in 331 models, based on the gauge group SU(3)C×SU(3)L×U(1)X, they are dominated by tree-level exchanges of a new heavy neutral gauge boson Z′. By exploiting this feature, observables related to FCNC decays of K, Bd and Bs mesons can be considered in several variants of 331 models. The variants are distinguished by the value of a parameter β that plays a key role in this framework. Imposing constraints on the ΔF=2 observables, we select possible ranges for the mass of the Z′ boson in correspondence to the values β=±k/3, with k=1,2. The results are used to determine the impact of 331 models on b→s processes and on the correlations among them, in the light of new experimental data recently released.
An Assessment of Knowledge, Attitude, and Practice (KAP) of Colorectal Cancer among Community Pharmacists in the Qassim Region of Saudi Arabia
Authors: Alshammari Mohammed , Al-Maktoum Saleh , Alsharidah Abdulrahman , Siddique Abubakar , Anaam Mohammed , Alsahali Saud , Almogbel Yasser , Alkhoshaiban Ali
Published: February 2024

Background: The global burden of colorectal cancer remains a major public health issue and one of the leading causes of death worldwide. In Saudi Arabia, it continues to be a health concern. Any delays in diagnosis for any reason may contribute to advanced complications; therefore, pharmacists’ knowledge and awareness of colorectal cancer are crucial for the welfare of society. Studies of colon cancer-related knowledge, attitude, and practice (KAP) among community pharmacists have not previously been conducted in the Al-Qassim region of Saudi Arabia. In the present study, therefore, we sought to investigate the KAP on colon cancer among pharmacists in Al-Qassim. Methods: This was a prospective, cross-sectional, observational study. A sample of 150 community pharmacists was recruited using a convenience sampling method. A self-administered questionnaire was used to evaluate levels of knowledge and practice. Results: Out of a total of 150 pharmacists, the majority of respondents (60.7%) possessed an adequate level of knowledge. About 50% of participants had heard of the early screening test, and 68.7% knew that colonoscopy is necessary in such scenarios. On the basis of their attitudes, 41.3% of study participants were aware of colon cancer symptoms and risk factors. In practice, however, the majority of pharmacists (81%) did not perform early cancer screenings, while 19% did screen when advised to do so by a physician. Conclusions: Our results indicate that pharmacists in Qassim have an adequate level of knowledge of colon cancer in terms of awareness, assessment, and screening. Since community pharmacists are among the most reliable members of the medical community, a greater awareness of colon cancer among pharmacists may improve public knowledge of the disease.
On-Chip Lasers for Silicon Photonics
Authors: Zhang Jiangwen , Shankar Aadithya G. , Wang Xihua
Published: February 2024

With the growing trend in the information industry, silicon photonics technology has been explored in both academia and industry and utilized for high-bandwidth data transmission. Thanks to the benefits of silicon, such as high refractive index contrast with its oxides, low loss, substantial thermal–optical effect, and compatibility with CMOS, a range of passive and active photonic devices have been demonstrated, including waveguides, modulators, photodetectors, and lasers. The most challenging aspect remains to be the on-chip laser source, whose performance is constrained by the indirect bandgap of silicon. This review paper highlights the advancements made in the field of integrated laser sources on the silicon photonics platform. These on-chip lasers are classified according to their gain media, including V semiconductors, III–V semiconductors, two-dimensional materials, and colloidal quantum dots. The methods of integrating these lasers onto silicon are also detailed in this review.
High-Power Mid-Infrared Quantum Cascade Laser with Large Emitter Width
Authors: Wang Yupei , Zhang Yuhang , Wang Jun , Cheng Yang , Zhao Wu , Wei Zhixiang , Zhou Dayong
Published: February 2024

High-power quantum cascade lasers (QCLs) have a wide application prospect. In this paper, a high-power high-beam-quality device with a large ridge width is demonstrated. The effect of different ridge widths on mode loss was studied, and the results showed that the mode loss decreased as the ridge width increased. Furthermore, as the width of the ridge increased, the temperature of the active region rose. In the experiment, the wafers were grown by metal–organic chemical vapor deposition (MOCVD), and the ridge width of the device was controlled by wet etching. A laser with a ridge width of 15 µm and a length of 5 mm achieved an output of 2.2 W under 288 K continuous wave (CW) operation, with a maximum slow-axis divergence angle of 27.2° and a device wavelength of 5 μm. The research results of this article promote the industrial production of base transverse mode QCL.
Time-Course Transcriptomic Analysis Reveals Molecular Insights into the Inflorescence and Flower Development of Cardiocrinum giganteum
Authors: Wei Yu , Li Aihua , Zhao Yiran , Li Wenqi , Dong Zhiyang , Zhang Lei , Zhu Yuntao , Zhang Hui , Gao Yike , Zhang Qixiang
Published: February 2024

Cardiocrinum giganteum is an endemic species of east Asia which is famous for its showy inflorescence and medicinal bulbs. Its inflorescence is a determinate raceme and the flowers bloom synchronously. Morphological observation and time-course transcriptomic analysis were combined to study the process of inflorescence and flower development of C. giganteum. The results show that the autonomic pathway, GA pathway, and the vernalization pathway are involved in the flower formation pathway of C. giganteum. A varied ABCDE flowering model was deduced from the main development process. Moreover, it was found that the flowers in different parts of the raceme in C. giganteum gradually synchronized during development, which is highly important for both evolution and ecology. The results obtained in this work improve our understanding of the process and mechanism of inflorescence and flower development and could be useful for the flowering period regulation and breeding of C. giganteum.
Plasma-Driven Sciences: Exploring Complex Interactions at Plasma Boundaries
Authors: Ishikawa Kenji , Koga Kazunori , Ohno Noriyasu
Published: February 2024

Plasma-driven science is defined as the artificial control of physical plasma-driven phenomena based on complex interactions between nonequilibrium open systems. Recently, peculiar phenomena related to physical plasma have been discovered in plasma boundary regions, either naturally or artificially. Because laboratory plasma can be produced under nominal conditions around atmospheric pressure and room temperature, phenomena related to the interaction of plasma with liquid solutions and living organisms at the plasma boundaries are emerging. Currently, the relationships between these complex interactions should be solved using science-based data-driven approaches; these approaches require a reliable and comprehensive database of dynamic changes in the chemical networks of elementary reactions. Consequently, the elucidation of the mechanisms governing plasma-driven phenomena and the discovery of the latent actions behind these plasma-driven phenomena will be realized through plasma-driven science.
Describing the Drying and Solidification Behavior of Single Suspension Droplets Using a Novel Unresolved CFD-DEM Simulation Approach
Authors: Buchholz Moritz , Weis Dominik , Togni Riccardo , Goniva Christoph , Heinrich Stefan
Published: February 2024

With increasing computational capacities and advances in numerical methods, a simulation-based process and product design approach for spray dried products has become the focus of many researchers. In this context, a novel unresolved CFD-DEM simulation approach for single suspension droplets is presented, which models the drying and solidification process in a hot gas environment. The solidification process is described by the formation of bonds between the primary particles in the suspension droplet, showing a plausible solidification behavior, which starts when a critical solid concentration is reached at the droplet surface. The drying conditions for the single-droplet simulations are determined from a large-scale spray dryer simulation for different droplet size classes. The resulting solid particles from the CFD-DEM simulation show a higher tendency to form hollow particles at high drying rates when the locking point is reached at earlier stages of the drying process. Using these results, suitable operating conditions for the spray dryer can be determined, which favor the formation of particles with a targeted morphology.
A Study of the Top-Coal-Drawing Law of Steeply Inclined and Extremely Thick Coal Seams in the Wudong Coal Mine
Authors: Cao Jiantao , Wu Longquan , Lai Xingping , Yan Baoxu , Zhu Haoyu , Qiao Hao
Published: February 2024

In addressing the issue of a low drawing rate in a steeply inclined and extremely thick coal seam, this study focused on the engineering background of the +575 horizontal working faces in the Wudong Coal Mine. By utilizing physical similarity simulation experiments, research was carried out on the top-coal-drawing rate and the gangue ratio at different coal-drawing intervals in horizontal segment mining for steeply inclined and thick coal seams, in which the relationships between the top-coal-drawing law and the drawing interval and technologies were revealed. The discrete element method was used to establish a numerical simulation model for the horizontal segment mining of steeply inclined and thick coal seams, and the roof-drawing law in the cases of the three-interval-group-of-support and drawing-once-every-two-support methods were analyzed before finally obtaining the optimal drawing technology. Through field practice, the coal-drawing effect of the technology was verified. The results indicated that the logarithmic functional relationship between the top-coal-drawing rate and the gangue ratio was established, and the optimal control indicator for top coal drawing was reached when the gangue ratio reached from 13% to 18%. The top-coal-drawing rate for the three-interval-group-of-support approach was higher than that of the method for drawing once every two supports. It was determined that the optimal mining technology was using a one-web-cutting-with-one-drawing approach for a three-interval-group-of-support method at a top-coal-drawing rate of 69.14%, which was 10.86% higher than that of the original technology. The research results further enriched the theory of top coal drawing in steeply inclined and extremely thick coal seams, thereby providing a reference and guidance for such mining operations.
An Injection-Mold Based Method with a Nested Device for Microdroplet Generation by Centrifugation
Authors: Li Jichen , Li Wen , Wu Bizhu , Bu Wenting , Li Miaomiao , Ou Jinyan , Xiong Yuxiang , Wu Shangtao , Huang Yanyi , Fan Yong , Men Yongfan
Published: February 2024

Microdroplets have been widely used in different fields due to their unique properties, such as compartmentalization, single-molecule sensitivity, chemical and biological compatibility, and high throughput. Compared to intricate and labor-intensive microfluidic techniques, the centrifuge-based method is more convenient and cost-effective for generating droplets. In this study, we developed a handy injection molding based method to readily produce monodisperse droplets by centrifugation. Briefly, we used two three-dimensional (3D) printed master molds with internal cavities to forge two coupled sub-molds by injecting polydimethylsiloxane (PDMS) and casted these two PDMS sub-molds into a nested structure that clamps the micro-channel array (MiCA) by injecting polyurethane resin. This method enables the generation of various sizes of monodispersed microdroplets by centrifugation with proper parameters within 10 min. To assess the performance of this method, homogeneous fluorescent hydrogel microspheres were generated and droplet digital polymerase chain reaction (ddPCR) was carried out. Overall, this method offers high-throughput droplet generation, reduces costs compared to other methods, and is user-friendly.
Global Modeling of Heat-Integrated Distillation Column Based on Limited Local Measurements
Authors: Cong Lin , Liu Dengpan , Ling Huaizhi
Published: February 2024

The heat-integrated distillation column (HIDiC) has more energy-saving potential than conventional distillation columns. However, its nonlinearity and coupling effects pose significant challenges for the online operation of the HIDiC. To overcome these challenges, it becomes necessary to utilize accurate nonlinear models for design optimization or control schemes. Traditional modeling methods require extensive tray information, implying the impractical use of numerous sensors in real-world applications. This paper proposes a modeling approach for the HIDiC based on a limited number of measurements. It only requires the measurement of a finite amount of tray information to construct a global model of the HIDiC. This method serves as an online observer, providing real-time information about the entire column, and also enables the prediction of tray concentration changes. The proposed model forms the basis for developing model-based online monitoring and control schemes. Experimental simulation results demonstrate that the proposed method achieves high accuracy in global observation and prediction for the HIDiC.
A Novel Prediction Model for Steam Temperature Field of Downhole Multi-Thermal Fluid Generator
Authors: He Yanfeng , Huang Zhiqiang , Dou Xiangji , Zhang Yisong , Hua Le , Guo Jing
Published: February 2024

Aiming at the low efficiency of heavy-oil thermal recovery, a downhole multi-thermal fluid generator (DMTFG) can improve the viscosity reduction effect by reducing the heat loss of multi-thermal fluid in the process of wellbore transportation. The steam generated by the MDTFG causes damage to the packer and casing, owing to the return upwards along the annular space passage of the oil casing. To mitigate this damage, a heat transfer model for multi-channel coiled tubing wells and a prediction model for the upward return of the steam temperature field in the annulus were established with the basic laws of thermodynamics. Models were further verified by ANSYS. The results indicate the following four conclusions. First of all, when the surface pressure is constant, the deeper the located DMTFG, the shorter the distance for the steam to return would be. It is easier to liquefy the steam. Second, the higher the temperature of the steam produced by the downhole polythermal fluid generator, the larger the upward distance of the steam would be. Third, the higher the steam pressure at the outlet of the downhole polythermal fluid generator, the smaller the distance of steam upward return would be. Finally, the larger the diameter of the multi-channel conversion piping, the greater the distance of the steam return would be. It is meaningful to provide valuable theoretical guidance for packer position designing in the field. Meanwhile, the study also provides a modeling basis for the subsequent study of artificial intelligence in the downhole temperature field.
Missionary Writings during the Canton Exile (1666–1671): Crisis in the Manchu-Christian Relationship
Authors: Meynard Thierry
Published: February 2024

During their Canton exile (1666–1671), European missionaries wrote an impressive number of reports and letters which have not been systematically studied until now. After presenting a detailed analysis of the institutional background of the 25 missionaries who arrived in Canton, we analyze the first internal reports about the Calendar Case. Then, we discuss three important Jesuit works by Gabiani, Grelon and Rougemont, who attributed the crisis to the opposition of the Manchus to Christianity. The distrust of the Canton Jesuits towards the Manchus throws a new light into the approach of Christianity towards politics and religion in China.
Religious Journalists’ Ethics on Communicating Science: The Case of Ultra-Orthodox Reportage in Israel
Authors: Golan Oren , Mishol-Shauli Nakhi
Published: February 2024

While religious dogma and science are often viewed at odds, scientific knowledge is increasingly integrated into religious journalism. This challenges the epistemic tenets that underlie the worldviews of religious readers. In this study, we aim to investigate the role of religious journalists as science gatekeepers and, more specifically, uncover their ethos in advocating science communication to their audience, amid widespread ambivalence. To this end, we focus on the ethical gaze of ultra-Orthodox (Haredi) Jews in Israel. An enclaved religious group that has a history of challenging scientific precepts and has of late demonstrated various levels of ambivalence and resistance to scientifically inspired policies made during the COVID-19 pandemic. To this end, we conducted in-depth interviews with 20 Haredi editors, radio and print/online journalists, engaged with science reporting before and during the COVID-19 outbreak. The findings unveil several ethical facets employed by Haredi journalists: care, community, professionalism, and religion. The findings also outline the interaction between professional, religious, and communal codes of conduct, as they play out in bounded mediascapes. Accordingly, religious journalists’ role breaches traditional boundaries as they respond and strive to integrate multiple sources of knowledge for what they see as the betterment of their devout readers.
Eosinophilic Cationic Protein and Immunoglobulin E: Unraveling Biomarkers in Chronic Pediatric Cough
Authors: Lazova Snezhina , Naydenova Kremena , Velikova Tsvetelina
Published: February 2024

Although the cough reflex is one of the essential protective mechanisms in the respiratory tract, it is considered a considerable health problem in adults and children when it becomes chronic and hypersensitive. However, the need for biomarkers for chronic cough in children and adults is critical. The problem with cough is also a severe symptom in hypersensitivity children. Respiratory infections are a considerable challenge for pediatricians, especially in allergic children. The term cough hypersensitivity syndrome, although introduced in adults, was questioned for children. Eosinophil cationic protein (ECP) is a promising marker for chronic cough but still needs to be validated and proved in clinical settings. In this review article, we aimed to discuss the possible role of ECP in connection to IgE for chronic cough in children.
An Integral Approach to Well-Being in Transnational Families: A Brief Proposal for Best Practices
Authors: Barros Carlos , Hanenberg Peter
Published: February 2024

Although the study of migration has shifted its focus from an individual perspective (on those who emigrate) to also include their integration networks in the country of destination, it is also necessary to consider the dynamics with their families in the country of origin. With an integral focus on the analysis of Portuguese transnational families, this paper aims to reflect on how the connection between those who emigrate and those who stay can promote greater resilience, presenting best practices for interventions among these dynamics and generations. Using a post-positivist paradigm and semi-structured interviews, we developed a qualitative approach with three exploratory studies: (1) Portuguese young adults living abroad (N = 22); (2) parental figures living in Portugal with adult children living abroad (N = 20); and (3) experts in the fields of academic and psychosocial work with similar people (N = 8). The data were analyzed using N-Vivo software (ed.11 and 14). The general results lead us to reflect on the dynamics of relationships, where digital and face-to-face spaces participate simultaneously, even though there are different challenges and ways of using digital means. We also found a change in expectations regarding the norms and values perceived by this generation of emigrants, which leads us to consider the importance of intercultural values since transnational families greatly increase transculturality, which can promote resilience among these groups. The data also alert us to the need to train intervention professionals in multidisciplinary areas, always taking the cultural context into account.
Analyzing Vulnerabilities of Disaster Risk Management Systems of Local Governments in South Korea: Evidence from National Audit Office Reports
Authors: Cho HyoungSuk , Choi NakHyeok
Published: February 2024

The capacity of local governments to act as frontline disaster management agencies is crucial to urban sustainability and disaster risk management systems. However, vulnerabilities in the management systems can hinder the effectiveness of disaster risk management, affecting the resilience and sustainable development of urban areas. This study examines vulnerable areas of disaster risk management from a practical perspective, based on audit findings conducted by the Board of Audit and Inspection (BAI). The stages of disaster risk management are classified as prevention, preparedness, response, and recovery. The disaster risk management activities that local governments should undertake at each stage have been identified and summarized. The vulnerabilities and associated cases related to disaster risk management were comprehensively analyzed by compiling the results of local government disaster risk management audits conducted after 2015. This study revealed vulnerabilities in areas such as disaster management funds, prevention facilities, safety inspections, forecasting and warning systems, and resident evacuation, all of which are integral to maintaining urban sustainability. To avoid the recurrence of these issues, this study suggests that local governments should develop and implement improvement measures for each vulnerable area. The findings of this study can serve as valuable guidelines for local governments on ways to enhance their disaster risk management systems.