bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic Screen forDrosophilaTranscriptional Regulators Phosphorylated in Response to Insulin/mTOR Pathway
Authors: Liu Ying , Mattila Jaakko , Hietakangas Ville
Published: June 2020

Insulin/insulin-like growth factor signaling (IIS) is a conserved mechanism to regulate animal physiology in response to nutrition. IIS activity controls gene expression, but only a subset of transcriptional regulators (TRs) targeted by the IIS pathway is currently known. Here we report the results of an unbiased screen for Drosophila TRs phosphorylated in an IIS-dependent manner. To conduct the screen, we built a library of 857 V5/Strep-tagged TRs under the control of Copper-inducible metallothionein promoter (pMt). The insulin-induced phosphorylation changes were detected by using Phos-tag SDS-PAGE and Western blotting. Eight proteins were found to display increased phosphorylation after acute insulin treatment. In each case, the insulin-induced phosphorylation was abrogated by mTORC1 inhibitor rapamycin. The hits included two components of the NURF complex (NURF38 and NURF55), bHLHZip transcription factor Max, as well as the Drosophila ortholog of human proliferation-associated 2G4 (dPA2G4). Subsequent experiments revealed that the expression of the dPA2G4 gene was promoted by the mTOR pathway, likely through transcription factor Myc. Furthermore, NURF38 was found to be necessary for growth in larvae, consistent with the role of IIS/mTOR pathway in growth control.
POST-CATASTROPHIC CITY TEXT: THE CITY READING IN THE CITY IN THE POSTWAR EAST AND CENTRAL EUROPE
Authors: Blacker Uilleam
Published: June 2020

In the material, the author addresses a multidimensional memory problem - not only as a constituent of social life but also as a feature of its functioning in urban space. The author presents the interpretations of memory against the background of urban transformations. The complexity and multidimensionality of this phenomenon are emphasized not only in the usual methodological field but also in literary practice. Literature acts as a means of accumulating memory despite the disappearance or destruction of one or the other in urban space. The traumatic experience is of particular importance. The example of the twentieth century reflects the various cases of the existence of memories of the tragic past. Kyiv, Lviv, Wroclaw, Kaliningrad and several other cities during the Second World War have faced the transformation of the usual landscape. That was both the realities of time and the policies against certain groups who have been harassed and destroyed. The practice of work and interaction with one or another component of the past, measures of governmental bodies are analyzed. After these tragic periods, the memory in a peculiar manner was lost. The cities in the region in one way or another came to return and actualization of this experience in the modern world. Critical in this process is the literary practice that "returns" and "opens" the memory of urban space. Complex topics require the involvement of a large number of disciplines in order to form an objective vision of the urban past.
SONGS AND POEMS OF THE "BIG CITY": TO THE QUESTION OF CULTURE AND LIFE OF MARIUPOL IN THE FIRST HALF OF THE 19th CENTURY
Authors: Chernukhin Yevhen
Published: June 2020

Тhere are several fragments of Іtalian, Russian and Ukrainian folk songs and poems among various texts, written with Greek letters, in the Urum manuscript dating from the first half of the 19th cent. The very presence of such texts, the character of their transcription indicates the spread of ІItalian, Russian and Ukrainian song culture and, in some degree, literature among the Turkish speaking Greeks of Mariupol in the first decades of their residence in Azov region.
Kesesuaian Lahan Budidaya Rumput Laut Eucheuma Cottonii di Perairan Tarakan dengan Faktor Pembatas Variabilitas ENSO dan Musim
Authors: Avianti Evie , Hendiarti Nani , Handayani Tuty
Published: June 2020

Satelit inderaja oseanografi Aqua MODIS dan altimetri digunakan untuk mempelajari perubahan parameter lingkungan perairan Tarakan (suhu, klorofil-a, arus permukaan) terhadap variabilitas ENSO dan Musim, agar diperoleh pemahaman dinamika oseanografi selama perioda El Nino (Desember 2008, Januari-Februari 2009), La Nina (September-Oktober-November 2010), dan Normal ((Mei-Juni-Juli 2012), Musim Barat (Desember, Januari, Februari selama 2008, 2009, 2010, 2012), dan Timur (Juni, Juli Agustus selama 2009, 2010, 2012). Analisis kesesuaian lahan budidaya Eucheuma cottonii menggunakan pengukuran langsung pada 11 titik sampling tgl. 11 Juli 2013 di perairan pantai Amal dan Mamburungan, dan P. Sadau dengan parameter suhu, salinitas, kecerahan, turbiditas, kimia keasaman, nitrat, fosfat, kalium. Hasil penelitian menunjukkan faktor lingkungan sangat dipengaruhi variabilitas ENSO dan Musim. Perairan timur Tarakan memiliki tingkat kesesuaian lebih tinggi daripada bagian barat. Arus Lintas Indonesia mempengaruhi transfer massa air dari kolam panas Pasifik Barat memasuki perairan Tarakan. Pada perioda El Nino dan Musim Timur perairan Tarakan timur memiliki tingkat kesesuaian tinggi dan selama La Nina dan Musim Barat tingkat kesesuaian tinggi berpindah ke utara perairan Tarakan. Analisis kesesuaian lahan budidaya dengan metoda scoring dan pembobotan menunjukkan perairan sekitar pantai Amal sampai selatan memiliki kesesuaian paling tinggi dan pantai Mamburungan dan P. Sadau dengan kesesuian sedang. Analisis tingkat kesesuaian di perairan Tarakan menggunakan data satelit inderaja memberikan informasi pada perioda El Nino berada di pantai Amal dan Tanjung Simaya, perioda La Nina di Tanjung Simaya dan Juata, perioda Normal di Tanjung Binalatung dan Simaya, Musim Barat di Tanjung Simaya dan Juata, dan Musim Timur di pantai Amal dan Tanjung Selayang.
Online Graduation of Doctors During the COVID-19 Pandemic
Authors: Blythe Andrew , Jones Imogen , Chakraborty Natasha
Published: June 2020

This article was migrated. The article was marked as recommended. In March 2020, the United Kingdom declared a nationwide lockdown, a public health intervention in response to the COVID-19 pandemic. In addition, the increasing pressures on the country's publicly funded healthcare system, the National Health Service, required the early graduation of final year medical students so that they could join the workforce. Bristol Medical School responded to this health crisis by graduating 226 final year students. Since social distancing policies resulted in the prohibition of social gatherings, university graduation ceremonies were cancelled. The medical school felt it important to mark the students' qualification as these young doctors were to begin their careers amidst an unprecedented global health emergency. An online graduation ceremony was held on the video conferencing platform Zoom. This was attended by university staff and students from their homes across the UK and elsewhere in the world. Students commemorated their qualification by submitting photographs of themselves celebrating in homemade graduation robes and mortar boards which were included in the online event. The ceremony was a memorable occasion and created a sense of community in a time of social isolation. This novel situation gave rise to a unique celebration attracting media coverage and was reported on national TV and radio news bulletins along with newspapers. The structure for the online graduation ceremony outlined in this paper may be replicated for other graduation ceremonies or celebrations affected by the COVID-19 lockdown.
Copy or Rewrite: Hybrid Summarization with Hierarchical Reinforcement Learning
Authors: Xiao Liqiang , Wang Lu , He Hao , Jin Yaohui
Published: June 2020

Jointly using the extractive and abstractive summarization methods can combine their complementary advantages, generating both informative and concise summary. Existing methods that adopt an extract-then-abstract strategy have achieved impressive results, yet they suffer from the information loss in the abstraction step because they compress all the selected sentences without distinguish. Especially when the whole sentence is summary-worthy, salient content would be lost by compression. To address this problem, we propose HySum, a hybrid framework for summarization that can flexibly switch between copying sentence and rewriting sentence according to the degree of redundancy. In this way, our approach can effectively combine the advantages of two branches of summarization, juggling informativity and conciseness. Moreover, we based on Hierarchical Reinforcement Learning, propose an end-to-end reinforcing method to bridge together the extraction module and rewriting module, which can enhance the cooperation between them. Automatic evaluation shows that our approach significantly outperforms the state-of-the-arts on the CNN/DailyMail corpus. Human evaluation also demonstrates that our generated summaries are more informative and concise than popular models.
Visual Agreement Regularized Training for Multi-Modal Machine Translation
Authors: Yang Pengcheng , Chen Boxing , Zhang Pei , Sun Xu
Published: June 2020

Multi-modal machine translation aims at translating the source sentence into a different language in the presence of the paired image. Previous work suggests that additional visual information only provides dispensable help to translation, which is needed in several very special cases such as translating ambiguous words. To make better use of visual information, this work presents visual agreement regularized training. The proposed approach jointly trains the source-to-target and target-to-source translation models and encourages them to share the same focus on the visual information when generating semantically equivalent visual words (e.g. “ball” in English and “ballon” in French). Besides, a simple yet effective multi-head co-attention model is also introduced to capture interactions between visual and textual features. The results show that our approaches can outperform competitive baselines by a large margin on the Multi30k dataset. Further analysis demonstrates that the proposed regularized training can effectively improve the agreement of attention on the image, leading to better use of visual information.
Clinical Impact of Plasma and Tissue Next-Generation Sequencing in Advanced Non-Small Cell Lung Cancer: A Real-World Experience
Authors: Bonanno Laura , Pavan Alberto , Ferro Alessandra , Calvetti Lorenzo , Frega Stefano , Pasello Giulia , Aprile Giuseppe , Guarneri Valentina , Conte PierFranco ,   on behalf of Rete Oncologica Veneta (ROV)
Published: June 2020

Background

Targeted agents have improved the outcome of a subset of non-small cell lung cancer (NSCLC). Molecular profiling by next-generation sequencing (NGS) allows screening for multiple genetic alterations both in tissue and in plasma, but limited data are available concerning its feasibility and impact in real-world clinical practice.

Methods

Patients with advanced NSCLC consecutively referring to our Institution for potential eligibility to VISION trial (NCT02864992) were prospectively enrolled. They were already screened with standard method, and EGFR/ALK/ROS-1 positive cases were excluded. NGS was performed in plasma and tissue using the Guardant360 test covering 73 genes and the Oncomine Focus Assay covering 59 genes, respectively.

Results

The study included 235 patients. NGS was performed in plasma in 209 (88.9%) cases; 78 of these (37.3%) were evaluated also in tissue; tissue only was analyzed in 26 cases (11.1%). Half of the tissue samples were deemed not evaluable. Druggable alterations were detected in 13 (25%) out of 52 evaluable samples and 31 of 209 (14.8%) of plasma samples. Improved outcome was observed for patients with druggable alterations if treated with matched targeted agents: they had a longer median overall survival (not reached) compared with the ones who did not start any targeted therapy (9.1 months; 95% confidence interval, 4.6–13.6; p = .046). The results of NGS testing potentially also affected the outcome of patients treated with immunotherapy.

Conclusion

Systematic real-life NGS testing showed the limit of tissue analysis in NSCLC and highlighted the potentiality of genetic characterization in plasma in increasing the number of patients who may benefit from NGS screening, both influencing the clinical decision-making process and affecting treatment outcome.

Implications for Practice

Genetic characterization of cancer has become more important with time, having had positive implications for treatment specificity and efficacy. Such analyses changed the natural history of advanced non-small cell lung cancer (aNSCLC) with the introduction of drugs targeted to specific gene alterations (e.g., EGFR mutations, ALK and ROS-1 rearrangements). In the field of cancer molecular characterization, the applicability of the analysis of a wide panel of genes using a high-throughput sequencing approach, such as next-generation sequencing (NGS), is still a matter of research. This study used NGS in a real-world setting to systematically and prospectively profile patients with aNSCLC. The aim was to evaluate its feasibility and reliability, as well as consequent access to targeted agents and impact on clinical outcome whenever a druggable alteration was detected either in tumor tissue samples or through liquid biopsy.
Environmental assessment of concrete beams strengthened with fibre-reinforced polymer
Authors: Zhang Yurong , Huang Tao , Wang Yuanfeng , Zhang Junzhi , Wang Jingjing
Published: June 2020

As concerns grow over sustainable development, it is important to consider properly the environmental implications of using fibre-reinforced polymers to strengthen concrete structures. Since the load capacity of a structure has an effect on its relative environmental impact, an energy–mechanical index, in which both energy consumption and mechanical aspects are taken into account, was proposed for evaluating the integrated environmental performance of strengthening solutions. Life-cycle assessment was used to evaluate the energy use, and corresponding experiments were designed to obtain the load capacity of reinforced concrete beams with different strengthening solutions. Moreover, Monte Carlo simulation was adopted to analyse the parameter uncertainty of the life-cycle assessment. The strengthening experiments indicated that the carbon-fibre-reinforced-polymer strengthening solution had a more efficient improvement impact on load capacity compared with the basalt-fibre-reinforced-polymer solutions. The improvement with one carbon-fibre sheet was equivalent to that with two basalt-fibre sheets. However, the carbon-fibre strengthening solution consumed more energy than the basalt-fibre strengthening solutions due to its high embodied energy. In addition, the energy–mechanical index of the basalt-fibre strengthened beams was far lower than that of the carbon fibre ones, whether the determined approach or the probability-based method was adopted, indicating the superior integrated performance of the basalt-fibre-reinforced-polymer strengthening solution.
SON DEHA: THEODOR W. ADORNO
Authors: Yıldırım Tamer
Published: June 2020

Theodor Wissengrund Adorno (1903-1969) hakkındaki biyografilerden birisi
olan eser, Adorno’nun son öğrencilerinden Detlev Clausen tarafından
yazılmıştır. Kitabın adına “deha” kelimesinin eklenmesinin Adorno’nun metinleriyle
bir ilişkisi vardır. Çünkü Adorno deha kavramını yaratıcı özneyle sanat
yapıtını, sahibinin bir belgesine dönüştüren ile aynı anlamda kullanılmaktan
kurtarılmaması gerektiğini belirterek açıklamıştı. Bu tanımlamaya uygun olarak Clausen,
Adorno’nun hayatını temel uğraşlarıyla iç içe sunmaya çalışmıştır. Yani
Adorno’yu sadece felsefi yönüyle veya hayatının önemli kısımlarıyla veya
sanatçı yönüyle değil bir bütün olarak anlatmaya çalışmıştır. Genel olarak günümüzde
de Adorno kendi dönemindeki diğer Frankfurt Okulu temsilcilerinden daha yoğun
bir şekilde ele alınmakta ve incelenmektedir. Muarızları onu, teorinin renksiz
dünyasından başka bir şey bilmeyen başarısız bir sanatçı olarak gösterse de biyografisinden
hareketle dramatik ama başarılı bir yaşam yaşadığını söyleyebiliriz.
Analysis of students’ mathematical connection abilities in solving problem of circle material: transposition study
Authors: DİANA Nanang , SURYADİ Didi , DAHLAN Jarnawi Afgani
Published: June 2020

This study aims to describe the ability of students' mathematical connections in solving problems in the circle equation material through transposition studies. The method in this research is a descriptive qualitative approach, the techniques used in the study are tests, interviews, and documentation to explore data in research. Test and interview techniques were carried out in order to find out more about the ability of connections and generate knowledge about the transposition in making mathematical problem solving designs. The test is given to 3 students who have high ability, medium ability and low ability. Analysis of the data in this study is through the provision of problem solving tests and interviews using time triangulation, which provides tests and interviews for each student with a different time. The results in this study indicate that highly capable subjects have excellent mathematical connections and didactic knowledge is well utilized and able to provide alternative answers that differ from researchers so that a didactic transposition is formed, that is knowledge to be taught with knowledge, subjects of mathematical ability are able understand the problem well but are not careful enough in solving problem so that previous knowledge is underutilized, the subject of low mathematical ability is not able to understand the problem well and is unable to solve problems in the form of algebra so that the initial knowledge possessed is not well connected.
North American Yoga Practitioners’ Lived Experiences of Mind-Body Connection: A Phenomenological Study
Authors: Weinstein Rachel
Published: June 2020

The practice of yoga was born in India thousands of years ago and brought to North America gradually beginning in the 20th century. The traditional practice of yoga is spiritual in nature with an intention of purifying the mind and body, leading to an alleviation of suffering through connection with the Divine (i.e., liberation). Yoga has gained widespread popularity in North America, but whether North American yoga practice includes an intention on the purification of the mind-body, in contemporary practice often described as a mind-body connection, has yet to be explored. This research study investigated North American yoga practitioners’ experiences of mind-body connection in their practices. Six yoga practitioners residing in North America were interviewed for this study. Interviews were audiorecorded and transcribed. Phenomenological analysis was conducted to produce the essence data, and thematic analysis was conducted to produce the contextual data. Phenomenological themes regarding the co-researchers’ experiences of mind-body connection in their yoga practices were identified and grouped into four textural essences: (1) the experience of breath, (2) local or internal experiences, (3) an increased sense of awareness and mindfulness, and (4) transcendental and spiritual qualities. Four structural conditions that allow practitioners to experience mind-body connection during yoga practice were identified: (1) breath, (2) physical asana, (3) practitioner intentionality, and (4) environmental conditions. Findings of the current study suggest a capacity for North American yoga practitioners to experience mind-body connection that is essential to traditional yoga practice.
Maternal characteristics and the risk of neonatal mortality in Brazil between 2006 and 2016
Authors: Costa Pedro Henrique , Alves Luciana Correia , Beluzo Carlos Eduardo , Arruda Natalia Martins , Bresan Rodrigo Campos , Carvalho Tiago
Published: June 2020

Neonatal deaths account for more than 60% of infant deaths and are a major concern in Brazil. The reduction of the occurrence of these events appears to be more challenging than post-neonatal deaths, as such a reduction depends more on factors related to the pregnancy and childbirth than sanitary and health conditions. The aim of the present study was to evaluate the influence of maternal factors (schooling, marital status, and age) on the risk of neonatal mortality in Brazil between 2006 and 2016. Data were collected from the Brazilian Institute of Geography and Statistics as well as two information systems of the public health-care system: Mortality Information System and Live Birth Information System. The total valid sample size was 28,362,359 children. Visualization and classification methods were performed. The results revealed a considerably higher risk of neonatal deaths when the mothers were unmarried, had a low level of schooling, and were outside the 20-34-year-old age group. Different demographic profiles in Brazil exert an influence on neonatal health. The identification of the risk factors of neonatal mortality can assist in ensuring pregnancy, delivery, and a neonatal period of greater quality.
TERSİNE LOJİSTİK TEORİ VE UYGULAMALARININ SON 10 YILI: BİBLİYOMETRİK BİR ANALİZ
Authors: ERTURGUT Ramazan , GÜRLER Hasan Emin
Published: June 2020

Dünya ticaretinin değişen
dinamikleri, üretim teknolojilerindeki ve tüketim alışkanlıklarındaki kayda
değer farklılaşmalar yanında, Sivil Toplum örgütlerinin gittikçe güçlenmesi ve
hemen her alanda sürdürülebilirlik düşünce ve uygulamalarının yaygınlık
kazanması, ürünlerin geri kazanımı ve çevreye zarar vermeksizin bertaraf
edilmesi konusunda toplumların bilinçlilik düzeyini artırmıştır. Toplumların, uluslararası
örgütlerin ve STK’ların konuya artan bu ilgi düzeyi, lojistik yönetiminde ürün
geri kazanımı, yeniden üretim ve ürünlerin bertarafı veya tamir için geri
çağırma olarak bilinen tersine lojistik görüş ve uygulamalarına da daha fazla
önem atfedilmesine yol açmıştır. Bu çalışmanın odak ilgisi, son on yılda
tersine lojistik alanında ortaya konulan bilimsel çıktıların incelenerek
araştırma ve uygulamaların seyrini nitel bir çözümleme ile ortaya koymaktır.  Bu amaç doğrultusunda Web of Science
veritabanında tersine lojistik, yeniden üretim, yeniden kullanım, geri kazanım,
geri dönüşüm, yok etme, tersine akış, yenileme gibi konuya ilişkin anahtar
kelimeler kullanılarak tarama yapılmış ve toplamda 701 yayına ulaşılmıştır. Araştırma
yöntemi olarak Bibliyometrik Analiz ve İçerik Analizi yöntemleri birlikte
kullanılmıştır. Araştırma sonuçları; 2015 yılından itibaren niceliksel bir
yoğunlaşma olduğunu, araştırma makalesi ve ampirik analiz eksenli yayınların
ağırlık kazandığını ve üniversiteler bazında 
Tersine Lojistik temalı  en fazla
yayın yapan üniversitenin ABD’de bulunan Auburn Üniversitesi olduğunu ortaya
koymuştur. Ayrıca, özetlerde en fazla değinilen kavramın tedairk zinciri
olduğu, en fazla çalışılan konunun kapalı döngü tedarik zinciri yönetimi olduğu
ve en fazla kullanılan yöntemin analitik hiyerarşi süreci yöntemi olduğu tespit
edilmiştir.
Benefit of varicocelectomy in infertile men with varicocele
Authors: Awati Shreeharsha Mallappa
Published: June 2020

Background: Varicocelectomy does improve semen parameters and pregnancy rates in men with infertility. Various studies have shown the extent of benefit and also shown that some may not benefit. It is important to counsel the patients about the same. The present study was done to determine how much varicocelectomy is beneficial to infertile men with varicocele.Methods: A prospective observational cohort study was conducted on 25 patients undergoing varicocelectomy for infertility at St. John Medical College Hospital, Bangalore from 1st June 2013 to 31st May 2014. Clinical data, semen analysis, scrotal imaging was done and postoperatively semen analysis was done after three months. The data was analysed to find out how much was the benefit of varicocelectomy.Results: Twenty-five patients underwent varicocelectomy, all of them showed improvement of semen parameters. Fifteen of them had more than 50% of improvement. This showed that varicocelectomy is beneficial to about 60% of patients.Conclusions: Varicocelectomy is beneficial to infertile men with palpable varicocele and abnormal semen parameters.
Cognitive rehabilitation using occupational therapy models for adults with cognitive impairment: a case series
Authors: Pai Anuradha V. , Bankhele Jyotsna R.
Published: June 2020

Occupational Therapy is one of the primary professions with knowledge and skills to address the consequences of cognitive decline. Cognitive decline is caused by traumatic brain injury, non-traumatic neurological diseases, Ageing, Chronic psychiatry diseases. Recent thinking on cognitive rehabilitation places various approaches to a continuum, from restorative/ remedial approaches to cognitive compensatory approaches with four models within OT, and functional environmental approach with three models of intervention. Before using any of the above models, it is necessary to assess the needs of the patient, the demands of the environment and his cognitive ability. The issues faced by persons with cognitive dysfunctions demand interdisciplinary work to link the brain, behaviour and performance in everyday life. A 36-year-old male, 4years post-traumatic brain injury with anosognosia, disorientation and anomia was treated using a dynamic interactional model of cognitive retraining and showed dramatic recovery after 8 weeks’ therapy. A 65-year-old female diagnosed as Alzheimer's Dementia since two years with memory problems, neglect of ADL and visual hallucinations, disinhibited behaviour was treated for 8 weeks using Cognitive Disabilities model of 2011 and showed moderate recovery. A 73-year-old male diagnosed as Alzheimer's Dementia with forgetfulness, difficulty in money handling, disorientation and dependent in ADL was treated using Cognitive Disability Reconsidered model showed slight recovery. Each individual with cognitive problems due to disease, trauma and ageing behaves separately. Occupational therapy aims at maintaining independence in ADL and achieving the maximum level of performance in work and leisure.
Short term results of total knee arthroplasty in tertiary rural tier three government medical college and hospital
Authors: Abdul Aziz Ansari Muqtadeer , Sasidharan Nair Pradeepkumar , Malpani Punit S.
Published: June 2020

Background: The objective of the study was to assess the clinical and functional outcome of total knee arthroplasty (TKA) using posterior cruciate stabilizing (PS) design in tertiary rural government hospital with limited infrastructure using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and to offer a low cost option and assess post-operative pain relief in rural poor of the society and to compare the WOMAC score pre and post-operatively.

Methods: The study was conducted on patients who have undergone primary total knee arthroplasty in Department of Orthopaedics, Government Medical College and Hospital, Aurangabad from December 2018 to December 2019. The patients were assessed using the WOMAC score and X-rays. These evaluations were performed at 3, 6 and 12 months follow up visits.

Results: At 1 year follow up of 30 knees, the average pre-op WOMAC score of 79.5 improved to an average post-op score of 42.3. And knee flexion increased from 96.3 degree to 108.5 degrees both of which with a p value <0.0001 are statistically significant. One patient each had wound dehiscence and superficial infection. Patient satisfaction after the procedure was good-both in unilateral and staged bilateral TKA.

Conclusions: TKA reduces knee pain significantly and improves the functional ability of the patient. And to be able to do so in a tertiary government rural setup with no laminar airflow and with such great efficacy and minimal complications bodes well for the number of people living in rural areas suffering from knee pain.
The closer… the unsafer: may the lack of safe distance be a silent contributor to the burden of traffic crashes in Spain?
Authors: Alonso Francisco , Faus Mireia , Useche Sergio A.
Published: June 2020

Not keeping an adequate safe distance is one of the elements that are directly related to traffic accidents. The main objective of this research was to identify the aspects that modulate the safe distance-accidents relation. Specifically, the frequency and reasons why drivers do not keep the safe distance, the perception of drivers regarding the probability of penalty, the penalties imposed and their severity, and the drivers’ opinion on the effectiveness of such penalties in order to change this behavior. A questionnaire was administrated to a sample of 1,100 Spanish drivers having any kind of driving license. The results showed that only the 5,6% of drivers always or sometimes do not keep the safe distance. Among the specific reasons, the traffic conditions and congestions and drivers not realizing they were not keeping a safe distance were the most frequent ones. Likewise, drivers perceived that the probability of being caught (sanctioned) as a consequence of this misbehavior is considerably limited. Moreover, there were no respondents who had received a fine for not keeping a safe distance while driving. The results contrast with previous studies in which it is showed that not keeping a safe distance is a quite frequently behavior, and remark shat several efforts are needed for strengthen the awareness of people in this matter, with the aim of reducing traffic crashes related to it, and their high multidimensional burden for societies.
Adsorción de azul de metileno utilizando cáscara de yuca (Manihot esculenta) modificada químicamente con ácido oxálico
Authors: Albis Arrieta Alberto , Llanos Reales Hellman , Galeano Gil Jeffrey , García Moreno Daniela
Published: June 2020

En esta investigación se evaluó el potencial de la cáscara de yuca (Manihot esculenta) modificada con ácido oxálico para remover azul de metileno de soluciones acuosas. Se determinaron las mejores condiciones de temperatura (40-60 °C), tiempo (1-3 h) y relación másica ácido oxálico/biomasa (1,5-2) para la modificación. Se obtuvieron porcentajes de remoción de hasta 99,48% y capacidad de adsorción de 24,87 mg/g con cáscara de yuca modificada a 50°C por dos horas y 1,75 de relación ácido oxálico/biomasa. El proceso de adsorción se ajustó al modelo de isotermas de Freundlich y la cinética de adsorción a un modelo de pseudo segundo orden.
Cis-2 and trans-2-eisocenoic fatty acids are novel inhibitors for Mycobacterium tuberculosis Protein tyrosine phosphatase A
Authors: Savalas Lalu Rudyat Telly , Furqon Baiq Repika Nurul , Asnawati Dina , 'Ardhuha Jannatin , Sedijani Prapti , Hadisaputra Saprizal , Ningsih Baiq Nila Sari , Syahri Jufrizal
Published: June 2020

Small protein tyrosine phosphatase (PtpA) of Mycobacterium tuberculosis is attributed to the development of latent tuberculosis infection, and hence bocomes an interesting target for drug development. In this communication, inhibition of PtpA by naturally occurring fatty acids cis-2 and trans-2-eicosenoic acid is investigated. Mtb PtpA was heterologously expressed in Escherichia coli, and the activity of PtpA was inhibited by cis-2 and trans-2 eicosenoic fatty acids. Both compunds showed strong inhibition of PtpA activity with IC50 at low micromolar concentration. As comparison, trans-11-eicosenoic acid only slightly inhibit PtpA. In silico analysis confirmed the inhibition of PtpB by cis-2-eicosenoic acid by formation of several hydrogen bonds. These findings show that cis-2 and trans-2 eicosenoic fatty acids are potential candidates for latent tuberculosis inhibitors.
CONTRASTIVE APPROACH TO NUMERIC USAGE IN JAPAN AND IN THE ABAJADUN METHOD
Authors: Sunarni Nani , Kurnia Firmansyah Eka , Abdul Malik Zulfi , Rohmayani Yani
Published: June 2020

Purpose: The article presents both numeric implementation in Japan and the Arabic gematrical calculation (hisababajadun) in Indonesia. It is common for the people in Japan and Indonesia to believe in the power of numerals and to assume whether or not certain digits induce bad luck.

Methodology: The research applies a qualitative descriptive method through a contrastive approach.

Main Findings: Data analysis is based on both Koizumi's approach (1995) to the meaning of numbers in the Japanese language and Al Bani's view on hisababajadun. Our study shows that the numeric calculation in Japan uses luckiness as its ground while the hisababajadun builds its mechanism on birth date calculation according to Quranic Neuro-Hypnosis.

Implications/ Applications: The research may enrich existing theoretical references on the belief toward numbers in both Japan and Indonesia. While in practice, it may as well be a reference for the application of numeric calculation methods in both cultures.

Novelty/Originality of this study: This study is unique and novel as it enhances the understanding of the importance of numerals in two distinct cultures i.e., Japan and Indonesia. Moreover, this study sheds light on some crucial aspects of numeral calculation including how these numerals are used, what beliefs are attached to them and how and where these numerals are used for solving life problems.
Formação de professores e educadores ambientais: diálogos generativos para a práxis
Authors: Freire Laísa Maria , Rodrigues Cae
Published: June 2020

No presente trabalho argumentamos que analisar a produção científica (trabalhos apresentados) do Encontro Pesquisa em Educação Ambiental (EPEA) é trazer os contextos da prática para uma discussão atualizada sobre a Pesquisa em Educação Ambiental (PEA) no Brasil, abrindo caminhos para formulações teóricas em uma perspectiva da práxis. Caracterizamos os trabalhos apresentados no Grupo de Discussão de Pesquisa sobre “Formação de professores e educadores ambientais” do X EPEA e elaboramos um conjunto de questionamentos generativos como potencial agenda de pesquisa, ou enquadramento metodológico para a (des)(re)construção, ou (re)formulação de pesquisas e ações no âmbito da educação ambiental com foco na formação de educadores ambientais. Entre os limites conceituais-metodológicos atuais/remanescentes da PEA com foco na formação de professores e educadores ambientais discutidos, destacamos: a persistência do histórico gap entre teoria e prática; a desarticulação das “novas” teorias em relação aos contextos geo-epistemológicos do campo ambiental; a ausência de diálogos Norte-Sul e a não-presença de epistemologias do Sul. A ênfase principal dos questionamentos levantados e da agenda de pesquisa proposta é a potencial superação desses limites no sentido da práxis ambiental.
Desvelando as pesquisas em educação ambiental em contexto não escolar
Authors: Oliveira Araújo Maria Inêz , Nascibem Fábio Gabriel , Vilar de Almeida Renata
Published: June 2020

Diante das alterações ambientais, em consequência das práticas antrópicas, é necessário desenvolver novas mentalidades que busquem caminhos para reduzir as pressões humanas na degradação ambiental. O artigo tem como objetivo apresentar caminhos trilhados em trabalhos de pesquisa em Educação Ambiental não formal. Para tanto, foi realizado um levantamento dos principais conceitos abordados e métodos utilizados nos artigos apresentados na comunicação oral do Grupo de Discussão de Pesquisa (GDP) em contextos não escolares, no X Encontro de Pesquisa em Educação Ambiental (EPEA), em 2019. Dos artigos avaliados, foram reconhecidas três categorias de conceitos: pertencimento, relação sociedade-natureza e o próprio conceito de educação ambiental; e duas categorias de método: oito artigos trabalharam a pesquisa com atividades formativas, e dez buscaram compreender o contexto e as opiniões dos participantes. Tais caminhos sinalizam uma postura de respeito à pluralidade de saberes e de manifestações, compatíveis com a pluralidade do mundo, na busca de concretizar  uma educação ambiental dialógica, acessível, democrática, diversa, cidadã, política e crítica.
UTEHA FILOZOFIJE: ŠOPENHAUEROVA INDIJA
Authors: VUKOMANOVIĆ MILAN
Published: June 2020

U ovom tekstu analiziraju se mogući hinduistički (vedantinski) uticaji na metafizičko i etičko učenje Artura Šopenhauera izloženo u njegovom delu Svet kao volja i predstava. Kantov uticaj na Šopenhauera dobro je poznat i u filozofiji često naglašavan. Nesumnjivo je, međutim, da su Šopenhauerovo učenje o volji, kao i njegova doktrina o svetu kao predstavi, bili u znatnoj meri podstaknuti vedantinskom filozofijom o čemu, uostalom, svedoči i on sam, pozivanjem na taj korpus literature. S druge strane, njegova etička doktrina je bila pod izvesnim uticajem ranog budizma, ali je taj aspekt u ovom kontekstu samo delimično istaknut. U uvodnom delu rada se razmatraju i mogući izvori Šopenhauerovog saznanja o religijama i filozofijama Indije u kontekstu razvoja evropske indologije početkom XIX veka.
ULOGA SKRBNOG MIŠLJENJA I EMPATIJE U OBRAZOVANJU
Authors: RUPČIĆ KELAM DARIJA , STEINER JELIĆ SANDRA , KELAM IVICA
Published: June 2020

Svaki bi ozbiljni obrazovni sustav danas, u suvremeno doba, trebao uzeti u obzir i u sebe ucijepiti oblik učenja kako misliti, odnosno razvijati kritičko mišljenje. Kada govorimo o obrazovanju, onda bi krajnja svrha odgojno-obrazovne aktivnosti trebala biti povratak subjektu, što znači razvoj emancipiranog, samomislećeg, autonomnog pojedinca, kritičkog mislitelja i samosvjesnog pojedinca. Uvježbavanjem (auto)refleksije i kritičkog mišljenja pomažemo pojedincu u dubljem razumijevanju i interpretiranju činjenica. Slijedom Liessmannove definicije neobrazovanosti koja se pojavljuje u svojem suvremenom pojavnom obliku kao poluobrazovanost, koja je odustajanje od htijenja da se uopće išta razumije, istaknut ćemo važnost filozofskih temelja skrbi, skrbnog mišljenja i potrebe razvoja empatije kao važnih fenomena u izgradnji cjelovite ličnosti, obrazovnog pojedinca, kritičkog subjekta, te mogućnost promjene postojećih odnosa unutar društva kojemu obrazovani pojedinac teži sudjelovati. Postavljamo pitanje, mogu li nam odgoj za skrb i empatiju, unutar odgojno-obrazovnog sustava pomoći u razumijevanju problema suvremenog svijeta i načinu nošenja s izazovima koje društvo pred nas danas postavlja?
„METODOLOŠKI POJAM ISTINE“ I EPISTEMOLOŠKE TENDENCIJE U KLASIČNOM PRAGMATIZMU Č. S. PERSA I V. DŽEMSA
Authors: MILENKOVIĆ DUŠAN
Published: June 2020

U radu se analizira Habermasova interpretacija Persovog pragmatizma i njegove težnje ka primeni teorijskih dometa naučne metodologije u rešavanju problema koji pripadaju domenu epistemologije. U skladu sa ovom interpretacijom, u radu se pokazuje kako Pers u svojim najpoznatijim tekstovima ne uspeva da ostane u okvirima teze o promišljanju saznanja iz perspektive metoda naučnog istraživanja, bez obzira na njegovu otvorenu kritiku tradicionalne filozofije. Iako sam Habermas ne govori u knjizi Saznanje i interes o učenju Vilijama Džemsa, u radu se razmatra u kojoj meri ovaj autor takođe zastupa tezu o „metodološkom pojmu istine“, kako u svojoj kritici tradicionalne filozofije, tako i u stavovima u kojima izlaže sopstvenu teoriju saznanja. Rad se približava zaključku da se ni u Persovoj, ni u Džemsovoj filozofiji ne može pronaći Habermasov „dosledni pragmatizam“, budući da oba autora posežu za teorijskim rešenjima preuzetim iz tradicionalne epistemologije, ne ostajući u okvirima zastupanja „metodološkog pojma istine“.
Príncipes virtuosos y mujeres engañosas: de la historia de Siyawash en el Shahnamé de Ferdousí al cuento marco del Sendebar medieval
Authors: Shirmahaleh Shekoufeh Mohammadi
Published: June 2020

El presente artículo investiga el recorrido literario del mito de Siyawash, uno de los más conocidos de Irán y Asia Central, partiendo del Shahnamé de Ferdousí, pasando por el Sendbadnamé persa y aterrizando finalmente en el Sendebar medieval castellano. El estudio busca destacar cómo la estructura relacionada con dicho mito se repite en las nombradas obras, y tras un viaje de Oriente a Occidente, se retoma en el cuento marco de uno de los conjuntos cuentísticos más importantes de la herencia hispana.
The Problem of the Collision of Lives from the Standpoint of Philosophical Reflection
Authors: Khmelevskaya Svetlana A.
Published: June 2020

The Object of the Study is situations of collision of lives, in which the realization of the right to life of one person collides with the realization of a similar right of another; these are situations where the right to life of one person (group of people) can be secured only by taking this right from another person (other people). The Subject of the Study is the c collision of lives, considered from the perspective of philosophical analysis, which allows us to approach their study comprehensively, find their deep foundations, and present them as a personal and social problem. The Purpose of the Study is to show the difficulties in resolving these collision, both in legal and moral aspects, and to reveal possible ways to resolve them. Main Theoretical Provisions of the Article. The article substantiates the idea that the problem of collision of lives is a philosophical problem, and broadly refers to a number of situations when saving the life of one person (group of people) is possible only by taking the life of another person (group of other people). The philosophical analysis required a typology of these situations. In this regard, the article presents a typology based on the features of choice in a situation of collision of lives: the choice between saving one's own life and saving the life of another person; a choice made by a third person; a choice made by a researcher (patient, subject, or their relatives) when applying biomedical technologies that relate to the boundaries of life; a choice made at the level of the state or society as a whole. Some of the situations related to the collision of lives are resolved through the mechanism of legal regulation, while others are resolved by public consensus, self - control on the part of the scientific community, finding a fair balance of private and public interests, and moral choices based either on the ethics of utilitarianism or the ethics of egalitarianism. But both ethical concepts imply the use of the principle of «the lesser of two evils» in the situation of choice, which often generates a sense of guilt in the person who made the choice. From the standpoint of the moral ideal, the choice in a situation of collision of lives will always be unfair, since the life of each person has an absolute value and there is always a victim in this choice, who loses his life. Therefore, the principle of «lesser evil» is relevant only within the framework of situational ethics. However, the problem of the collision of lives has deep ontological roots, the origins of which should be sought in the laws of biological evolution.
Sociocultural Values of Russians: Development Dynamics (Based on Data from World Values Survey Studies)
Authors: Fomichyov Tat’yana V.
Published: June 2020

The Object of the Study is the sociocultural values of the Russians. The Subject of the Study is the dynamics of sociocultural values of Russians based on data from international cross-cultural studies in 1990 - 2011. The Purpose of the Study is to interpret theoretically and empirically the notion of sociocultural values of Russians on the basis of World Values Survey data, to identify the transformation processes (dynamics) of sociocultural values of Russians. The Main Provisions of the Article. The theoretical side of the subject of study: a description of the vector of the dynamics of sociocultural values of Russians. The empirical side of the subject of study: revealing the empirical trajectory of the dynamics of sociocultural values of Russians. The article provides a theoretical overview of the sociological source base of the concept of "sociocultural values of Russians" in different perspectives (in the materials of Russian and foreign authors). The information base of the research is quite variable and is represented by various sources (abstracts of dissertations, monographs, articles, etc.). The theoretical and methodological basis of the study are the concepts of R. Inglhart and A.Maslow. The main method of obtaining empirical information in the study is the secondary analysis of documents (analysis of data from the World Values Survey project). The main results of the work. «Pioneering» works related to the topic of transformation of socio-cultural values have been identified. The author defines the term «sociocultural values». Theoretical interpretation and operationalization of the concept of "sociocultural values" have been made. The concept of operationalization of the concept of «sociocultural values of Russians» is presented. The dominant and least popular sociocultural values of the Russians during the studied period are revealed. The trajectory of the value priorities of the Russians has been formed. The conclusion is made about the Russians' commitment to traditional values in the context of permanently occurring transformation processes. Scope of the research results: formation of the concept of transformation of socio-cultural values of Russians; to innovate training courses in the discipline «Sociology of Culture».
Editorial
Authors: Carneiro Celso Dal Ré , Pereira Sueli Yoshinaga , Gonçalves Pedro Wagner , Torres Branco Frésia Soledad Ricardi
Published: June 2020

O ano 2020 será inconfundível, pois a população vivencia, no momento em que este texto é redigido, angustiantes ameaças à saúde humana, no bojo de uma catástrofe humanitária de proporções inéditas. Diante do enorme desafio da pandemia do COVID-19, importante conhecimento será obtido desse quadro geral de impotência. Agora, perguntas se avolumam com rapidez, respostas objetivas tardam a surgir, e coloca-se no centro do cenário mundial a relação entre ciência e política: “estamos aprendendo que o lugar da ciência na política é determinado não pela lógica dos fatos, mas pela influência fundamental dos valores humanos” (Sarewitz, 2020). Haverá correções de rumos, de grande interesse para as Ciências da Terra, uma vez que boa parcela do conhecimento a ser gerado diz respeito ao modo como o homem se relaciona com a natureza. Enfim, trata-se de uma relação geoética, na medida em que a humanidade aplica as Geociências para dar forma ao “nicho humano”, empregando profissionais da área como instrumentos operacionais (Bohle, 2020)...
Terapi Bekam dalam Menurunkan Intensitas Dismenore dan Tanda-Tanda Vital (Nadi dan Tekanan Darah)
Authors: Purwaningrum Vania Pangestika , Armini Ni Ketut Alit , Ulfiana Elida , Kusumaningrum Tiyas
Published: June 2020

Introduction: Dysmenorrhea made intolerance to work and absence from work or school. This situation made someone to be unproductive. This study was aimed to determine that cupping therapy is effective to reduction the intensity of dysmenorrhea and vital signs (pulse, systolic and diastolic blood pressure).Methods: This type of research was a quasi-experimental design study with the posttest design only design . The population were all of the female students aged 18-23 years who had primary dysmenorrhea. The sampling method was quota sample with 42 samples that divided into experimental group and control group with 21 samples. The independent variable was cupping therapy and the dependent variable was the intensity of dysmenorrhea and vital signs. The instruments used in this study were numeric rating scale, questionnaire sheets and observation sheets. Data analysis used Mann Whitney U Test.Results: The result showed that dysmenorrhea intensity variable had (p=0.000) its means that there are differences in the effectiveness of cupping therapy in the control group to decrease the intensity of symptoms of dysmenorrhea. In the pulse variable the results were (p= 0.596), systole blood pressure (p= 0.213), and diastole (p=0.639) (p>0.05).Conclusion: It can be concluded that, there are differences in effectiveness between groups given cupping therapy with the control group to decrease the intensity of dysmenorrhea, for pulse variables, systolic and diastolic blood pressure there was no difference between the two groups.