bluuebunny/crossref_metadata_2025 huggingface dataset:
Uncovering Ion Transport Mechanisms in Ionic Liquids Using Data Science
Authors: Umaña J. E. , Cashen Ryan K. , Zavala Victor M. , Gebbie Matthew A.
Published: November 2024

Batteries play a key role in the energy transition but suffer from safety concerns arising from the electrochemical instability of organic electrolytes. Ionic liquids are emerging as promising, non-flammable electrolytes for next-generation batteries. Yet, designing ionic liquids to facilitate redox ion transport has proven challenging, because ionic liquids are concentrated electrolytes where ion-ion interactions cause pronounced deviation from classical electrolyte scaling theories which assume viscosity governs mobility. Machine learning studies show that ionic liquid transport properties are challenging to predict from molecular descriptors, preventing rational design. Here, we pursue a broader data-centric approach to provide insight into ionic liquid design by merging databases of experimental properties and computational molecular features for 218 ionic liquids across 127 publications. We find that ionic liquids are well-described by a modified Arrhenius model that captures structure-driven ion transport in correlated electrolytes, yielding energy barriers of around 20-30 kJ/mol. This exhibits remarkable agreement with the approximately 25 kJ/mol screened ion pair interaction energy derived from surface forces measurements, suggesting links between mechanisms of ion transport and interfacial screening. We also use machine learning models to find that molecular features can predict some properties, such as density, while failing to predict properties that rely on long-range correlations, such as viscous dissipation. Our study reveals that data science tools can be leveraged to reveal non-classical transport scaling relationships and alternative materials descriptors that promise to be transformative for designing ionic liquids and other correlated electrolytes for next-generation batteries. All data and models are shared as open-source code.
Migrative Reductive Amination of Ketones Enabled by Multitasking Reagents
Authors: Khegay Artem , Hall Dennis
Published: November 2024

Skeletal editing and “single-atom logic” are emerging strategies that accelerate compound synthesis and open new chemical space by modifying organic molecules using unconventional bond forming processes. These new strategies are particularly attractive to access important biologically active classes of compounds, such as secondary amines, which are key synthetic intermediates and components found in numerous pharmaceutical agents. Herein, a practical modification of the classical reductive amination of ketones and aldehydes, a staple reaction in drug discovery research, was developed to provide isomeric amines by way of a migratory reductive amination (MRA). This one-pot method combines three distinct chemical reactions in a single flask, without solvent changes, via the orchestrated addition of two inexpensive and non-toxic multitasking reagents: Zn(II) salts and a hydrosilane. Both reagents display exceptional orthogonality with a synergetic role in all three stages of the process, lending a procedure that embodies many of the ideals of green chemistry. This MRA method demonstrates a wide scope of acyclic and cyclic ketones and aldehydes with aliphatic or aromatic groups, including complex molecules such as drug intermediates and natural products with an exceptionally low E-factor compared to established methods. Remarkably, MRA enables the expeditious preparation of cyclic secondary amines of varying ring size, including a cyclopentanone-to-piperidine ring-edit that provides a direct access to the most common saturated heterocycle in drug discovery.
A Spectrochemical Series for Electron Spin Relaxation
Authors: Kazmierczak Nathanael , Xia Kay , Sutcliffe Erica , Aalto Jonathan , Hadt Ryan
Published: November 2024

Controlling the rate of electron spin relaxation in paramagnetic molecules is essential for contemporary applications in molecular magnetism and quantum information science. However, the physical mechanisms of spin relaxation remain incompletely understood, and new spectroscopic observables play an important role in evaluating spin dynamics mechanisms and structure-property relationships. Here, we use cryogenic magnetic circular dichroism (MCD) spectroscopy and pulse electron paramagnetic resonance (EPR) in tandem to examine the impact of ligand field (d-d) excited states on spin relaxation rates. We employ a broad scope of square-planar Cu(II) compounds with varying ligand field strength, including CuS4, CuN4, CuN2O2, and CuO4 first coordination spheres. An unexpectedly strong correlation exists between spin relaxation rates and the average d-d energy (R2 = 0.97). The relaxation rate trends as the inverse eleventh power of the excited-state energies, whereas simplified theoretical models predict only an inverse second power dependence. These experimental results directly implicate ligand field excited states as playing a critical role in the ground state spin relaxation mechanism. Furthermore, ligand field strength is revealed to be a particularly powerful design principle for spin dynamics, enabling formation of a spectrochemical series for spin relaxation.
Relativistic CASPT2/RASPT2 Program along with DIRAC software
Authors: Masuda Yasuto , Noda Kohei , Iwamuro Sumika , Nakatani Naoki , Hada Masahiko , Abe MINORI
Published: November 2024

Exploring electronic states in actinide compounds is a critical aspect of nuclear science. However, considering relativistic effects and electron correlation in theoretical calculations poses a complex challenge. To tackle this, we developed the CASPT2/RASPT2 program along with the DIRAC program, enabling calculations of electron correlation methods using multiconfigurational perturbation theory with various relativistic Hamiltonians. Currently, we employ a method that combines the improved virtual orbital (IVO) approach and CASCI methodologies as reference functions, deviating from the traditional use of CASSCF. Additionally, we implemented the RASCI-RASPT2 method to treat larger active spaces and parallelized the entire program. Due to the intricate process of selecting orbital spaces in CASPT2 and RASPT2, we offer a GUI program to assist with input creation. All these programs and tutorials are freely accessible on GitHub for anyone to use. In our benchmark calculations, we demonstrated the efficiency of parallelization by utilizing 1 to 256 cores for CASCI-CASPT2 calculations on the UO₂²⁺ molecule. Despite encountering some anomalies, we achieved commendable parallelization efficiency with CASCI and CASPT2 computational times. We also computed the vertical excitation energies of UO₂²⁺ using the RASCI-RASPT2 approach. By adapting the IVO and setting the maximum number of holes and electrons to three for RAS1 and RAS3, we obtained trends consistent with those reported in previous studies using alternative methods. We plan to continue improving the program in the future, believing that its widespread use will contribute to further development in actinide chemistry.
HISTÓRIA E TECNOLOGIA NO ENSINO DE MATEMÁTICA: DA AMBLYTOME À HIPÉRBOLE COM GEOGEBRA
Authors: Sánchez Ivonne C. , Mendes Iran Abreu , Silva Maria Deusa Ferreira
Published: November 2024

Este artigo explora o desenvolvimento histórico e epistemológico dos métodos de determinação da equação da Hipérbole, desde as noções de Menêcmo com a Amblytome e as contribuições de Apolônio, até a abordagem moderna com o GeoGebra. O foco é apresentar uma trajetória que integra a História da Matemática para apoiar o ensino da Hipérbole, enfatizando conceitos de razão e proporcionalidade em geometria e seu tratamento algébrico. Utilizando o GeoGebra, destacamos a importância de visualizar e compreender as correlações geométricas e algébricas, facilitando a aprendizagem dos alunos ao apresentar a Hipérbole como lugar geométrico. Este trabalho visa fomentar novas discussões sobre a integração da História da Matemática e tecnologias digitais no ensino, promovendo uma abordagem interdisciplinar e inovadora.
TINGKATAN MATH ANXIETY SISWA SMP BERDASARKAN GENDER
Authors: Juniardi Muhammad Aqil , Rahmi Depriwana , Yuniati Suci , Kurniati Annisah
Published: November 2024

Penelitian ini memiliki fokus utama untuk mengeksplorasi perbedaan tingkat math anxiety atau kecemasan dalam matematika siswa jenjang Pendidikan SMP berdasarkan jenis kelamin atau dikenal dengan gender. Metode deskriptif kuantitatif digunakan sebagai metode penelitian, dengan mengambil 30 siswa yang berasal dari kelas IX sebagai sampel penelitian. Metode pengumpulan data dilakukan melalui penggunaan angket math anxiety yang telah teruji validitas dan reliabilitasnya. Data angket math anxiety siswa digunakan untuk menghitung tingkat kecemasan matematis siswa berdasarkan klasifikasi kategori math anxiety dan menggunakan uji independent sample t-test dalam menganalisis math anxiety berdasarkan gender. Hasil penelitian diperoleh dari 37% siswa mengalami tingkat math anxiety tinggi. Sedangkan hasil analisis diperoleh kesimpulan bahwa antara tingkat math anxiety siswa laki-laki dan perempuan menunjukkan tidak ada perbedaan atau perubahan yang signifikan melalui uji independent sample t-test dengan nilai t yaitu 1,032 dan nilai sig. 0,311 0,05. Penelitian ini dapat menjadi rekomendasi sebagai landasan pertimbangan dalam mengembangkan proses belajar mengajar yang efisien dan efektif sesuai dengan karakteristik siswa SMP/Sederajat.
PENERAPAN MODEL PROBLEM BASED LEARNING UNTUK MENINGKATKAN KEMAMPUAN NUMERASI DAN KEMANDIRIAN BELAJAR PESERTA DIDIK KELAS XI-5 SMA NEGERI 1 SEWON
Authors: Rengganis Erika Yudhi , Astuti Dwi , Yulistryarini Tiwi
Published: November 2024

Penelitian ini bertujuan untuk meningkatkan kemampuan numerasi dan kemandirian belajar peserta didik kelas XI-5 SMA Negeri 1 Sewon dengan menerapkan model problem based learning. Jenis penelitian ini adalah penelitian tindakan kelas, dengan subjek penelitian peserta didik kelas XI-5 SMA Negeri 1 Sewon yang berjumlah 30 peserta didik. Desain penelitian yang digunakan dalam penelitian ini adalah model Kemmis dan Mc Taggart. Penelitian dilaksanakan dalam tiga siklus dengan satu pertemuan disetiap siklusnya dan dilaksanakan pada bulan Februari sampai dengan Maret tahun 2024. Data dikumpulkan dengan teknik observasi, tes, dan dokumentasi. Teknik analisis data yaitu deskriptif kuantitatif dengan kriteria keberhasilan lebih dari 70% peserta didik mempunyai kemampuan numerasi dan kemandirian belajar minimal pada kategori tinggi berdasarkan hasil tes dan angket. Hasil penelitian menunjukkan bahwa penerapan model problem based learning dapat meningkatkan kemampuan numerasi dan kemandirian belajar peserta didik kelas XI-5 SMA Negeri 1 Sewon. Peningkatan kemampuan numerasi peserta didik terlihat dari hasil tes yang menunjukkan 26,67% peserta didik memiliki kemampuan numerasi minimal tinggi pada pra tindakan, kemudian menjadi 83,33% peserta didik memiliki kemampuan numerasi minimal tinggi pada siklus ke-3. Sedangkan peningkatan kemandirian belajar peserta didik terlihat dari hasil angket yang menunjukkan 56,67% peserta didik memiliki kemandirian belajar minimal tinggi pada pra tindakan, menjadi 76,67% peserta didik memiliki kemandirian belajar minimal tinggi pada siklus ke-3. Berdasarkan peningkatan tersebut, kemampuan numerasi dan kemandirian belajar peserta didik pada siklus ke-3 telah memenuhi kriteria berhasil penelitian yaitu lebih dari 70% peserta didik mempunyai kemampuan numerasi dan kemandirian belajar minimal pada kategori tinggi
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE TEAM GAMES TOURNAMENT (TGT) TERHADAP HASIL BELAJAR SISWA SMK
Authors: Fadilah Choirunisa Fitri , Mutaqin Anwar , Setiani Yani
Published: November 2024

Tujuan penelitian ini adalah untuk mengetahui model pembelajaran kooperatif tipe Teams Games Tournament (TGT) berpengaruh signifikan terhadap hasil belajar siswa kelas X SMKN 5 Kota Serang. Jenis penelitian ini adalah eksperimen semu pada desain Nonequivalent Pretest-Posttest Control Group Design. Populasi yang ada didapatkan dengan teknik cluster random sampling,  dengan menggunakan instrumen penelitian berupa tes serta non tes. Instrumen tes berupa pretes-postes untuk mengukur hasil belajar aspek kognitif dan instrumen non tes berupa angket untuk mengukur aspek afektif. Teknik analisis data deksriptif hasil penelitian memperlihatkan, nilai rata-rata instumen tes hasil belajar ranah kognitif postes adalah 79,69 serta nilai rata-rata instumen non-tes hasil belajar ranah afektif angket 74,58. Stastistik Inferensial memakai uji one sample t-test didapatkan untuk instrumen tes hasil belajar ranah kognitif nilai sig- serta untuk instrumen non-tes hasil belajar ranah afektif nilai sig- yang mempunyai arti  ditolak serta  diterima. Jadi dapat disimpulkan terkait model pembelajaran kooperatif tipe TGT berpengaruh signifikan terhadap hasil belajar matematika.
RESPON SISWA TERHADAP BAHAN AJAR ETNOMATEMATIKA DENGAN PENDEKATAN KONTEKSTUAL UNTUK MENINGKATKAN KEMAMPUAN KOMUNIKASI MATEMATIS
Authors: Harahap Muhammad Syahril , Nasution Febriani Hastini
Published: November 2024

Penelitian ini bertujuan untuk mengengetahui respon siswa terhadap bahan ajar etnomatematika dengan pendekatan kontekstual unuk meningkatkan kemampuan komunikasi matematis siswa SMP Negeri  2 Padangsidimpuan. Penelitian ini merupakan penelitian studi kasus.Subjek dalam penelitian ini adalah 29 siswa kelas VIII-3 SMP Negeri 2 Padangsidimpuan. Teknik pengumpulan data dalam penelitian ini adalah angket, tes, dan dokumentasi. Instrument yang digunakan diantaranya 1) lembar angket angket repon siswa untuk melihat kepraktisan bahan ajar. Dilakukan uji coba produk dengan melihat respon penggunaan produk dan hasil tes siswa berdasarkan kemampuan komunikasi matematis. Berdasarkan hasil penelitian ini diperoleh kepraktisan bahan ajar dilihat dari hasil angket respon siswa denganmemperoleh rata-rata persentase 89,38% dengan kategori “Sangat Praktis” dan hasil persentase angket respon siswa menunjukkan bahwa mendapatkan respon positif sebanyak 86,2% yang artinya bahan ajar etnomatematika berhasil digunakan dengan baik karena telah memperoleh hasil lebih dari atau sama dengan 80%.
PENGARUH PENERAPAN ICE BREAKING BERBASIS DIGITAL TERHADAP MOTIVASI DAN HASIL BELAJAR MATEMATIKA KELAS X
Authors: Nikmah Nikmah , Dewi Hefi Rusnita
Published: November 2024

Tujuan dari penelitian ini dilakukan yaitu untuk mengetahui pengaruh penerapan ice breaking berbasis digital terhadap motivasi dan hasil belajar matematika kelas X. penelitian ini merupakan penelitian kuantitatif dengan pendekatan One group pre-post-test-design. Sampel dalam penelitian ini adalah kelas X di SMKS Ibnu Cholil Bangkalan yang berjumlah 21. Instrumen yang digunakan adalah lembar angket dan lembar tes. Teknik pengumpulan data yang digunakan berupa angket motivasi belajar dengan 20 pernyataan dan tes yang berisi 20 soal pilihan ganda. Teknik analisis data pada penelitian ini menggunakan uji t. Hasil analisis data uji t motivasi belajar mendapatkan nilai signifikat 0,0000,05  tolak dan  diterima yaitu ada pengaruh penerapan ice breaking berbasis digital terhadap motivasi  belajar matematika kelas X. Dan dibuktikan juga dari hasil perhitungan uji t nilai pretest dan posttest hasil belajar matematika kelas X yang mendapatkan nilai signifikat 0,0000,05 yang berarti bahwa  ditolak dan  diterima artinya ada pengaruh penerapan ice breaking berbasis digital terhadap hasil belajar matematika kelas X. Dapat diambil kesimpulan bahwa terdapat pengaruh penerapan ice breaking berbasis digital terhadap motivasi dan hasil belajar matematika kelas X.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE TEAM GAMES TOURNAMENT (TGT) BERBANTUAN KUIS INTERAKTIF GOOGLE FORM TERHADAP KEMAMPUAN PEMECAHAN MASALAH MATEMATIS SISWA
Authors: Nabilah Barikatun , Ismunandar Denni , Lestari Wiwit Damayanti
Published: November 2024

Berdasarkan pengalaman peneliti selama kegiatan Program Pengalaman Lapangan (PPL) di SMA Negeri 1 Lohbener, kemampuan siswa dalam menyelesaikan permasalahan belum optimal terutama ketika diberikan permasalahan kontekstual. Hal ini berdampak hasil belajar siswa menjadi rendah. Selain itu, penyampaian materi masih menggunakan metode ceramah belum mengkombinasikan dengan model pembelajaran kooperatif dan evaluasi pembelajaran belum mengkombinasikan dengan media kuis interaktif. Tujuan dalam penelitian ini adalah untuk mengetahui kemampuan pemecahan masalah matematis siswa setelah penerapan model TGT berbantuan kuis interaktif Google Form. Dalam penelitian ini menggunakan metode penelitian kuantitatif dengan pendekatan efektivitas perlakuan. Penelitian ini dilaksanakan di SMA NEGERI 1 Lohbener. Subjek dari penelitian ini adalah siswa kelas X-C yang berjumlah 36 siswa. Data utama yang dikumpulkan adalah data variabel kemampuan pemecahan masalah matematis. Untuk mengumpulkan data tersebut, peneliti menggunakan instrumen berupa tes. Berdasarkan hasil analisis data pada uji one sample test, didapatkan nilai signifikansi bahwa nilai sig = 0,909 0,05 maka H0 diterima. Dengan demikian penggunaan model TGT berbantuan kuis interaktif google form tidak efektif terhadap kemampuan pemecahan masalah matematis.
PENGARUH MODEL PEMBELAJARAN PROBLEM BASED LEARNING (PBL) BERNUANSA ETNOMATEMATIKA TERHADAP KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA SISWA KELAS VIII DI SMP NEGERI 2 BALANIPA
Authors: Radiah Radiah , Murtafiah Murtafiah , Herna Herna
Published: November 2024

Kemampuan pemecahan masalah merupakan hal penting dalam matematika. Namun, faktanya saat ini kemampuan pemecahan masalah matematika siswa masih rendah. Tujuan penelitian ini adalah untuk mengetahui apakah kemampuan pemecahan masalah masalah matematika siswa yang diajar dengan model pembelajaran Problem Based Learning bernuansa etnomatematika lebih tinggi dibandingkan dengan kemampuan pemecahan masalah matematika siswa yang diajar dengan model pembelajaran langsung. Jenis penelitian ini adalah penelitian kuantitatif dengan desain Nonequivalent Control Group Design. Penentuan sampel menggunakan sampling jenuh dimana kelas VIII A sebagai kelas eksperimen dan kelas VIII B sebagai kelas kontrol. Data penelitian dikumpulkan melalui instrumen penelitian berupa lembar observasi keterlaksanaan pembelajaran oleh guru, lembar observasi aktivitas siswa, dan lembar tes kemampuan pemecahan masalah matematika. Teknik analisis data menggunakan analisis deskriptif dan analisis inferensial dengan bantuan SPSS for windows. Hasil analisis deskriptif menunjukkan bahwa kemampuan pemecahan masalah matematika siswa yang diajar dengan model pembelajaran Problem Based Learning bernuansa etnomatematika berada pada kategori sangat tinggi sedangkan kemampuan pemecahan masalah matematika siswa yang diajar dengan model pembelajaran langsung berada pada kategori sedang. Kemudian hasil analisis inferensial menunjukkan bahwa kemampuan pemecahan masalah matematika siswa yang diajar dengan model pembelajaran Problem Based Learning bernuansa etnomatematika lebih tinggi dibandingkan dengan kemampuan pemecahan masalah matematika siswa yang diajar dengan model pembelajaran langsung. Pembelajaran matematika dengan model pembelajaran Problem Based Learning bernuansa etnomatematika dapat digunakan untuk meningkatkan kemampuan pemecahan masalah matematika siswa.
THE ROLE OF FINANCIAL BALANCE INDICATORS IN ASSESSING THE FINANCIAL PERFORMANCE OF THE ALGERIAN HYDROCARBON INSURANCE COMPANY AN ANALYTICAL STUDY FOR THE PERIOD 2021-2023
Authors: Mansour Manel , Ferhat Abdelkrim , Omane Ahmed
Published: November 2024

Objective: This study aims to evaluate the financial performance of the Algerian Company for Hydrocarbon Insurance from 2021 to 2023 using financial balance indicators. The goal is to identify strengths and weaknesses to guide future improvements.
 
Theoretical Framework: The study is based on financial performance evaluation theories, focusing on financial balance indicators to assess profitability, stability, and growth. It integrates financial analysis tools and techniques to provide a comprehensive view of organizational health.
 
Method: A descriptive-analytical approach was adopted, combining theoretical analysis of financial performance concepts with a case study of the company. Data were collected from the company's annual reports and field studies conducted at its central management in Algiers.
 
Results and Discussion: The findings reveal that the company has maintained strong financial balance indicators, ensuring financial independence and stability. Turnover showed consistent growth during the study period, highlighting operational efficiency, though further monitoring is recommended to sustain performance.
 
Research Implications: The study emphasizes the importance of regular financial performance monitoring using analytical tools. It provides practical insights for similar companies seeking to enhance financial stability and strategic decision-making.
 
Originality/Value: This study offers a unique analysis of the Algerian hydrocarbon insurance sector, providing valuable benchmarks for financial performance evaluation and actionable recommendations for continuous improvement.
MICROINSURANCE AS A TOOL FOR ENHANCING FINANCIAL INCLUSION IN THE INSURANCE INDUSTRY – A STUDY OF THE LIFE INSURANCE SECTOR IN INDIA
Authors: Cheraga Sabrina
Published: November 2024

Objective: The objective of this research is to examine the role of microinsurance in promoting financial inclusion within India's life insurance sector. It aims to analyze financial inclusion indicators from 2019 to 2023 to assess the effectiveness of microinsurance in providing affordable insurance solutions to low-income groups. Additionally, the study identifies challenges such as low awareness, financial literacy, and income constraints that hinder broader adoption.
 
Theoretical Framework: The theoretical framework is based on financial inclusion theory, highlighting microinsurance as a tool to provide affordable insurance to underserved populations. It integrates risk management theory, emphasizing insurance as a means to reduce vulnerability to financial shocks, and the diffusion of innovation theory, which explains the role of awareness and socioeconomic factors in adoption. Together, these theories link microinsurance to financial inclusion and its challenges.
 
Method: The study employs a quantitative approach, analyzing financial inclusion indicators in India's life insurance sector from 2019 to 2023. Data is collected from government reports, industry publications, and relevant financial databases to assess microinsurance penetration and its impact. The analysis identifies trends, challenges, and opportunities for improving financial inclusion through microinsurance.
 
Results and Discussion: The results indicate that microinsurance has significantly contributed to increasing financial inclusion by providing affordable life insurance solutions to low-income groups in India. However, the discussion highlights persistent challenges, including low awareness, limited financial literacy, and income constraints, which hinder broader adoption. Addressing these barriers through targeted education, policy interventions, and subsidies is essential to enhance microinsurance penetration further.
 
Research Implications: The research underscores the potential of microinsurance as a vital tool for advancing financial inclusion among underserved populations. It calls for policymakers and insurers to prioritize awareness campaigns, financial literacy programs, and innovative pricing models to bridge the existing gaps in accessibility and adoption.
 
Originality/Value: This study provides a unique contribution by focusing on the role of microinsurance in promoting financial inclusion within India's life insurance sector. It offers valuable insights into the challenges and opportunities of microinsurance adoption, emphasizing its significance as a tailored solution for low-income groups.
Comprehensive Bioinformatics Analysis Reveals Kirsten Rat Sarcoma Virus Oncogene (KRAS) as the Potential Biomarker of Esophageal Carcinoma
Authors: Muhammad Akram
Published: November 2024

In the current study, the expression of the Kirsten rat sarcoma virus oncogene (KRAS) in esophageal carcinoma (ESCA) was examined for its medical and therapeutic relevance. ESCA has a 20% five-year survival rate, placing it seventh in the world in terms of overall rate of mortality.  GEPIA2, UALCAN, OncoDB, cBioPortal, STRING, DAVID, and TIMER2 databases are among the bioinformatics tools used to conduct this investigation. According to the analysis, KRAS was significantly (P < 0.05) elevated in ESCA samples in contrast to normal tissues, demonstrating that it might play an active role in the proliferation of malignancies. Additionally, the study based on several clinicopathological features showed that KRAS were significantly up-regulated. ESCA patients had a worse overall survival rate (OS) as KRAS was significantly overexpressed. Besides this, the study carried out analyses of drug sensitivity, enrichment, and promoter methylation to inquire about their relationships to KRAS expression in ESCA. The KRAS mutation was demonstrated to have a significant impact on the progression of ESCA via the genetic changes that were observed using cBioPortal. In conclusion, the comprehensive analysis of the findings emphasizes the significance of KRAS up-regulation in the development of ESCA and its potential as a potential biomarker.
New Insights on the Roles of miR-21 in Cancer Development and Proliferation
Authors: Hayat Ahmad
Published: November 2024

MicroRNAs (miRNAs) are small noncoding RNAs strongly implicated in the control of gene expression post-transcriptionally. They account for a wide range of functions recognized as characteristic cancer signatures, including apoptosis, invasion, metastasis, and proliferation. MicroRNA-21 (miR-21) is well-recognized for its crucial role in various solid tumors, such as glioblastoma, ovarian cancer, non-small cell lung cancer, and many others. In numerous malignancies, miR-21 selectively targets multiple key components and influences a broad spectrum of cellular processes, including cancer stemness and cell death. The miR-21 gene exhibits both cancer-promoting and cancer-suppressing properties, though most research highlights its facilitative role in cancer development. MiR-21 mediates PTEN reduction to enhance PI3K/Akt signaling in cancer progression. Its overexpression inhibits apoptosis and significantly promotes pro-survival autophagy. The notable upregulation of miR-21 in cancerous tissues positions it as a promising cancer biomarker with considerable diagnostic and prognostic potential. This study aims to define the functional roles of miR-21 as a crucial regulator in various cancers and its potential as a therapeutic target.
Inhibition of Cancer Cell Growth by Baicalein via ESR1 Based on Molecular Dynamics Simulations
Authors: Kang Chao , Wang Mengke , Zhang Yongsong
Published: November 2024

This study investigates the mechanism by which baicalin inhibits cancer cell growth through estrogen receptor 1 (ESR1) using molecular dynamics simulations. The results show that baicalin primarily binds to the ligand-binding domain (LBD) of ESR1, interacting through hydrogen bonds and hydrophobic interactions. After binding, the overall and local conformations of ESR1 change, affecting its interactions with other proteins and thus modulating the signaling pathways of cancer cells. Binding free energy analysis indicates that the binding of baicalin to ESR1 is spontaneous and relatively stable. Additionally, baicalin can inhibit the binding of ESR1 to estrogen, blocking the estrogen signaling pathway and thereby suppressing the growth and proliferation of cancer cells. This study provides theoretical and experimental foundations for the potential use of baicalin as an anticancer drug, offering new insights and methods for the development of novel anticancer drugs. However, the study has some limitations, such as limited simulation time and simplified systems. Future research can extend the simulation time and consider more physiological factors to more accurately simulate the interactions between baicalin and ESR1.
Research Progress on Mouse Models of Breast Cancer Metastasis
Authors: Zhao Minjun , Qiao Haizhi , Zhang Jinku
Published: November 2024

Breast cancer metastasis is a major cause of treatment failure and patient mortality. Mouse tumor models largely replicate the pathophysiological processes of human tumors. Establishing mouse models of breast cancer metastasis helps to elucidate metastatic mechanisms, and in vivo imaging techniques enable dynamic monitoring of tumor cell metastasis in animals. This paper summarizes the mechanisms of breast cancer metastasis, the development, and application of various mouse breast cancer distant metastasis models over the past decade, and evaluates the characteristics and efficacy of each model to provide references for future experimental studies.
The use of a three-phase eddy current flaw detector to control the continuity of the material
Authors: Makarochkin Valeriy V. , Nikonova Galina V.
Published: November 2024

The use of single-element eddy current transducers in eddy current testing devices limits the flaw detector performance, since the formed eddy current contour corresponding to the average turn of the eddy current transducer coil is limited by the area of this turn and the scanning speed of the tested surface. The presence of several single-element eddy current transducers inevitably has a negative mutual influence. The paper presents the results of increasing the performance of a three-phase eddy current flaw detector (ECF), including increasing the scanning speed and reducing the mutual influence of single-element eddy current transducers. A three-element three-phase eddy current transducer is used as a source of the informative parameter in the ECF, represented by three single-element transformer transducers, the excitation windings of which are connected to a source of three-phase alternating high-frequency voltage. Based on the Wagner – Evans theory, a mathematical model is proposed that describes the formation of the so-called asymmetric system when the symmetry of a three-phase voltage system is violated. This system can be represented as a sum of symmetric components: direct, reverse, and zero sequences. Taking into account the mathematical model, a structural diagram of the eddy current tester has been developed. The diagram assumes that the exciting windings of the single-element converters that make up the flaw detector are connected to a source of three-phase symmetrical voltage, and the measuring windings receive the introduced voltage in the form of a three-phase system when the eddy current converter interacts with the test object. In addition, using a filter for symmetric components, the voltage of the reverse sequence is isolated, which is formed only when the symmetry of the introduced voltages on the measuring windings of the three-phase eddy current converter is violated and can be used as an informative parameter for detecting such defects as, for example, discontinuities in the test object. The obtained results can be used in eddy current flaw detectors based on electromagnetic non-destructive testing methods to detect defects of various natures.
The features of thermally stressed energy equipment tensometric studies under high temperatures and deformations conditions
Authors: Maslov Sergey V.
Published: November 2024

The purpose of the work is to solve the problem of constructing schemes and models taking into account the peculiarities of conducting full-scale strain gauge studies of structures operated at temperatures up to 550°C, in the elements of which local elastoplastic deformations may occur. To solve the problem, the results of strain gauge studies of a heat exchanger, the elements of which are subjected to intense thermal effects from a liquid metal coolant with variable temperature, were used. Based on the analysis performed, schemes for constructing measuring systems are proposed that are used at various stages of research and allow the use of equipment with alternative methods of powering strain gauge transducers. The use of alternative schemes for constructing a measuring system provides data on changes in the metrological characteristics of primary transducers directly in the process of a full-scale experiment. For this purpose, the principle of dependence of the magnitude of the dissipation of the temperature characteristics of strain gauges on changes in the temperature components of their output signals is used. To construct a mathematical model of creep of strain gauges at high temperatures, experimental results were obtained that made it possible to substantiate the exponential model of changes in the uninformative output signal associated with creep. As a result of the analysis performed, a method for determining the creep of strain gauges, based on measuring the output signals under cyclically changing deformation, was substantiated. Algorithms for taking into account errors associated with the creep of strain gauges under conditions of non-stationary thermal loading of the heat exchanger under study are proposed. As a result of the research, an adjustment was made to the experimentally obtained functions for changing the stress state of the structure under study. The results obtained make it possible to increase the reliability of the assessment of the strength and service life of power engineering structures, carried out on the basis of field studies.
Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024
Authors: Kohlenberg Anke , Svartström Olov , Apfalter Petra , Hartl Rainer , Bogaerts Pierre , Huang Te-Din , Chudejova Katerina , Malisova Lucia , Eisfeld Jessica , Sandfort Mirco , Hammerum Anette M , Roer Louise , Räisänen Kati , Dortet Laurent , Bonnin Rémy A , Tóth Ákos , Tóth Kinga , Clarke Christina , Cormican Martin , Griškevičius Algirdas , Khonyongwa Kirstin , Meo Marie , Niedre-Otomere Baiba , Vangravs Reinis , Hendrickx Antoni PA , Notermans Daan W , Samuelsen Ørjan , Caniça Manuela , Manageiro Vera , Müller Vilhelm , Mäkitalo Barbro , Kramar Urška , Pirs Mateja , Palm Daniel , Monnet Dominique L , Alm Erik , Linkevicius Marius
Published: November 2024

Analysis of 594 isolates of Escherichia coli sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase variants, mainly in ST131 clades A and C. Most frequent were bla
OXA-244 (n = 230) and bla
OXA-48 (n = 224), detected in 14 and 12 countries, respectively. Isolates carrying bla
OXA-244 have increased rapidly since 2021. The increasing detection of carbapenemase genes in the E. coli high-risk lineage ST131 is a public health concern.
A STUDY OF LINGUISTICS AND COMMUNICATIVE SKILLS FOR CREATING HEALTHY TEACHER-TAUGHT RELATIONSHIPS IN THE CLASSROOM TEACHING AND LEARNING PROCESS
Authors: Ansari Dr. Mohd. Talib Ather
Published: November 2024

The study of linguistics and communicative skills plays a pivotal role in fostering effective teacher-taught relationships, which are essential for successful classroom teaching and learning. This research paper explores how understanding the principles of linguistics and applying strong communication strategies can bridge gaps between teachers and students, enhance engagement, and create a supportive learning environment. The analysis delves into various linguistic approaches that support clear and meaningful interactions, the influence of non-verbal communication, and the impact of active listening on student participation. Additionally, the paper discusses the challenges teachers face in adapting communication styles to diverse classroom settings and provides strategies for overcoming these barriers. This study underscores the importance of teacher communication competence as a foundational element for promoting mutual respect, understanding, and collaboration in the educational process.
CUSTOMER SATISFACTION OF PEOPLE IN THE SHOPPING OF BRANDED AND NON-BRANDED ARTICLES THROUGH ONLINE-OFFLINE MODE
Authors: Pal Rohit Kumar , Chaudhary Uditanshu
Published: November 2024

This study attempts to compare the customer satisfaction of people in the shopping of branded and non-branded articles through online-offline mode. The null hypotheses were formulated for this study. The researcher has used a cross-sectional research design. The researcher has employed a quantitative survey method in the present study. Sample of the present study involved 600 customers above 18 years who are residing in the six blocks of district Dehradun. Purposive sampling technique was used to select the sample for the study. Consequently, 290 male and 310 female customers from the Dehradun district were chosen. Customer satisfaction was the dependent variable and type of articles and mode of shopping were the independent variables involved in the present study. Customer Satisfaction Scale developed by the researcher has been used to collect the data. Mean, S.D. and ‘t’ test have been used for the statistical analysis. Findings revealed that there was a significant difference in the customer satisfaction of people in the shopping of branded and non-branded articles. Customer satisfaction of people in the shopping of non-branded articles was found higher as compared to the shopping of branded articles. There was found a significant difference in the customer satisfaction of people in the shopping through online-offline mode. Customer satisfaction of people in the shopping through offline mode has been found higher as compared to the shopping through online mode.
SUSTAINABLE BUSINESS PRACTICES AND COMMERCE: PATHWAYS FOR ECONOMIC GROWTH AND ENVIRONMENTAL RESPONSIBILITY
Authors: L Ramesh , B Shiva Kumar
Published: November 2024

The transition toward sustainable business practices is increasingly becoming a priority as companies adapt to environmental, social, and governance (ESG) mandates. This article explores how sustainable business practices can support economic growth while addressing environmental concerns, with a specific focus on the commerce sector. Analyzing trends, challenges, and benefits, the paper identifies effective strategies for sustainability, concentrating on industries in Chitradurga and neighboring regions in Karnataka. The study highlights global best practices alongside local initiatives, assessing the role of stakeholders, and concludes with actionable recommendations to foster a sustainable and profitable commerce sector.
COMPOSITION, LENGTH-WEIGHT RELATIONSHIP, AND FISHING GROUND OF SHARKS LANDED AT PPS CILACAP, CENTRAL JAVA
Authors: Krisnafi Yaser , Dian Novianto  , Syam Baharuddin Sahid  , Ratih Purnama Sari
Published: November 2024

This study was conducted to analyze the catches of sharks, such as composition, length-weight relationship, and to determine the distribution of shark fishing areas. Every fishing activity has by-catch issues. Fishers commonly catch sharks as by-catch. These fishing activities will harm the shark ecosystem in the waters. This research was conducted in March – May 2021 at PPS Cilacap. The results of this study showed that A. superciliosus (paitan shark) was a common catches and its total catch was 1,820 kg. The next common catch was Carcharhinus falciformis and the total catch was 723 kg. The lowest catch was the Carcharhinus sorrah shark (sorrah shark) and its total catch was 16 kg. The growth of Carcharhinus falciformis was negative allometric because b-value <3. Meanwhile, the growth of A. superciliosus is positive allometric because b-value was > 3. Length-weight relationship of Carcharhinus falciformis and A. superciliosus was isometric, which means that the growth between length and weight is balanced. Shark fishing areas are located at coordinates 8º - 15º South and 100º - 111º East. The area of shark fishing is at coordinates 8º - 10º South and 108º - 110º East.
Keywords:       Composition, Length-Weight Relationship
DESIGN AND DEVELOPMENT OF A DEEP LEARNING-BASED AUTOMATIC FISHERIES LOGBOOK FILLING TOOL
Authors: Iqbal Muhammad , Tanhir Muhammad Fadhilah , Apriliansyah Bachtiar Adi , Pratama Xavercius Cezar , Nadja Kuntum Khaira , Lotaldy Alnodio , Wahyuningrum Prihatin Ika
Published: November 2024

Filling out a fishery logbook is critical in capturing fisheries to maintain fishery sustainability. However, manual logbook filling often leads to errors in data recording, which can impact the accuracy and quality of fishery data. This study propose the design of an automatic fisheries logbook filling tool based on Deep Learning, called FLOADS (Fisheries Logbook and Detection System). This system consists of instruments placed at the ship's hatch, equipped with a camera capable of detecting fish species, measuring the weight of individual fish passing through, and recording and sending data, along with the ship's position and speed, to a server on land. The development stages of the FLOADS include problem identification, tool design, prototype development, and field testing. The FLOADS prototype consisted of three parts: a fish collection container, a fish sliding area, and an Imaging Box with dimensions of 120 cm × 65 cm × 82 cm. Validation of the YOLOv5 model showed an accuracy rate of 99.07% and an F1-Score of 99.1% for recognizing the Tuna, Cakalang, and Tongkol (TCT) fish species. Field testing was conducted in Palabuhanratu using a 10 GT fishing vessel. The field testing results show that FLOADS performs well on board to detect objects with an accuracy rate of 89.1% and track vessel activities with reasonable accuracy.
Keywords:       Deep Learning, DeepSORT, Fisheries Logbook, Measurable Fishing, TCT.
BIOECONOMIC ANALYSIS OF RED SNAPPER (Lutjanus sp.) RESOURCES AT REMBANG REGENCY
Authors: Handayani Meri , Dian Purnama Fitri Aristi , Wijayanto Dian
Published: November 2024

Rembang Regency has quite large fishery potential in 2021, reaching 87,292.9 tonnes in Central Java. One of the catches with high economic value is red snapper (Lutjanus sp.). Red Snapper is a demersal fish obtained from the operation of Danish seine. The purpose of this study was to analyze the condition of red snapper resources in Rembang Regency using the bioeconomic approach of the Gordon-Schaefer model and to analyze the level of utilization and exploitation of red snapper (Lutjanus sp.) in Rembang Regency. The research used a descriptive method with a purposive sampling method to collect a sample of 90 respondents who owned Danish Seine gear at Tasikagung Fishing Port. The results of data processing obtained Maximum Sustainable Yield (MSY) with a CMSY value of 2,002 tons/year, EMSY of 8,857 trips/year. The Maximum Economic Yield (MEY) calculation obtained a CMEY value of 1,936 tons/year, EMEY of 7,241 trips/year, and optimal profit of IDR 74,773,571,716 and the calculation of the Open Access Equilibrium (OAE) where a COAE value of 1,194 tonnes/year is obtained, an EOAE of 14,483 trips/year. The permissible utilization rate of red snapper (Lutjanus sp.) in Rembang Regency is 3,670,532 kg/year. In the last 9 years, an average resource utilization rate of 45% was obtained and an average effort level of 158%. This level of effort has exceeded the fishing limit, so it is necessary to reduce or limit fishing efforts.
 
Keywords: MSY; MEY; Rembang Regency; Red Snapper; Gordon Schaefer
CATCH COMPOSITION AND CATCHABLE SIZE OF LOBSTERS (Panulirus spp) IN LEBAK BANTEN WATERS, INDONESIA
Authors: Sani Ndaru Narulita , Purbayanto Ari , Wahju Ronny Irawan
Published: November 2024

Information on the catch composition and catchable size of lobsters in Lebak waters remains limited, posing challenges for effective fisheries management. This study aims to assess the technical performance of the lobster fishery and analyse catch composition. Data on technical performance were collected through interviews with fishers and lobster collectors using random sampling, while a census approach was applied to measure carapace length and weight for 589 lobsters. A descriptive quantitative analysis was conducted to evaluate the length-weight relationship of lobsters. The findings indicate that fishers predominantly use polyamide monofilament gillnets with a mesh size of 3.5–4.0 inches, operating traditional outrigger boats of 2–3 GT and 7 GT for single-day fishing trips in Lebak waters. Panulirus homarus was the dominant species in the catch. The sex ratio of lobsters was imbalanced, and their growth pattern exhibited negative allometry (b < 3). An assessment of catch sizes against the standards set by PERMEN-KP No. 16/2022 revealed a high proportion of undersized lobsters in the Binuangeun Estuary, including P. penicillatus (78–83%), P. homarus (80–100%), P. ornatus (23%), P. longipes (90–100%), and P. versicolor (65–100%). Similarly, in the Cibareno Estuary, the percentages of undersized lobsters were P. penicillatus (84–100%), P. homarus (98%), P. ornatus (0%), P. longipes (100%), and P. versicolor (92%). These findings highlight the need for stricter management measures to ensure sustainable lobster fisheries in the region.
Keywords:       catchable, Lebak Banten waters, length weight, lobster, sex ratio
Las TIC en Educación Primaria a través del aprendizaje basado en
proyectos
Authors:   Escuela Universitaria
                        CEU de Magisterio de Vigo, Moriarty Pitarque Daniel , Fragueiro Barreiro Sandra ,   Escuela
                        Universitaria CEU de Magisterio de Vigo
Published: November 2024

En este trabajo se apuesta por la implementación de una metodología
activa e innovadora en Educación Primaria: el Aprendizaje Basado en
Proyectos (ABP). Se ha desarrollado una propuesta didáctica interdisciplinar
centrada en la implementación de proyectos STEAM (Ciencia, Tecnología,
Ingeniería, Arte y Matemáticas). En primer lugar, se presenta un marco
teórico que recoge las contribuciones académicas más relevantes, realizadas
por autores que son reconocidos en estos ámbitos académicos, acerca del
estudio de dicha metodología, así como de su relación con las TIC. Además,
se recopilan varios ejemplos de proyectos educativos que combinan estas dos
dimensiones, con el objetivo de fomentar en los niños y niñas habilidades,
conocimientos y actitudes beneficiosas para el mundo actual y el futuro, así
como para el desarrollo integral de su personalidad, promoviendo su
crecimiento intelectual, social y emocional. Finalmente, se evalúa el diseño
y la implementación de algunos de estos proyectos.
PENINGKATAN KAPASITAS POKDARWIS MELALUI PELATIHAN ADMINISTRASI KEUANGAN DI SAKRA BARAT KABUPATEN LOMBOK TIMUR
Authors: Hanani Tri , Rizki Novia , Agustiningsih Wulandari , Hartini Intan Juwita
Published: November 2024

The tourism sector is one of Indonesia's leading sectors. Pokdarwis is a community group that voluntarily cares about managing and improving regional tourism. Pokdarwis often receive funds for activities that must be managed and accounted for properly, including Pokdarwis of Rensing Sakra Barat Village. This community service activity aims to increase the capacity of Human Resources of Pokdarwis Sakra Barat, East Lombok Regency, through financial administration training. With this training, Pokdarwis is expected to be able to carry out complete and structured financial administration so that all finances are recorded and reported correctly. The activity was carried out for one day, on May 21, 2024, attended by the management and members of Pokdarwis at the culinary market, a local tourist spot they currently manage. The community service team presented material and examples of financial administration by linking the actual situation according to what was conveyed by Pokdarwis members. From the evaluation results, the management and members of Pokdarwis stated that the activity provided sufficient understanding and expressed satisfaction with the activity facilities.
Introdução: sobre experiências, pesquisas e debates
Authors: Moreli Alexandre
Published: November 2024

Para além do resultado do Seminário “10 anos de Lab-Mundi”, foi também por meio das noções de diálogo e de transmissão que este livro foi traçado.
Karl Polanyi e a terra como mercadoria no Brasil (séculos XVI – XIX)
Authors: Saiz Gustavo dos Santos Rey
Published: November 2024

O estudo da terra no Brasil, tanto das relações sociais quanto das práticas agrícolas, é tema comum e recorrente na historiografia.