bluuebunny/crossref_metadata_2025 huggingface dataset:
Disputas por la naturaleza y el territorio: una lectura desde la ontología relacional zoque
Authors: Ledesma Rodríguez Fermín
Published: March 2022

Desde la noción de ontología relacional, en este artículo se describe cómo la movilización de los pueblos zoques del norte de Chiapas, México, pone en juego la producción de relatos de seres sobrenaturales indígenas y cristianos que luchan contra la ronda petrolera 2.2 y otros proyectos extractivos, para revelar formas singulares de comprender y relacionarse con la naturaleza, en una región donde el gobierno lleva a cabo proyectos extractivos de diferentes características. Mediante la etnografía, se da cuenta de las formas simbólicas que se despliegan en las luchas socioambientales debidas a la disputa por el territorio y la naturaleza en el actual contexto de crisis ambiental global.
Kuraklık ve tuz stresinin V. vinifera x V. rupestris melezlerinin toplam fenolik bileşik ve antioksidan kapasiteleri üzerine etkileri
Authors: YÜKSEL KÜSKÜ Damla , SÖYLEMEZOĞLU Gökhan
Published: March 2022

Çalışmada; melezleme ıslahı ile elde edilmiş olan 11 adet Karadimrit x 140 Ruggeri genotipine kuraklık ve tuz stresi uygulanmış, fenolik bileşik ve antioksidan miktarlarındaki değişimler tespit edilmiştir. F1 genotiplerinde tuz uygulamaları sonucunda, yapraklarda ölçülen toplam fenolik bileşik (TFB) içerikleri 13 388-30 093 mg GAE kg-1 KA ve antioksidan kapasite (TEAK) miktarları 125.7-301.6 μmol troloks g-1 KA arasında değerler vermiştir. Kuraklık uygulaması sonuçlarına göre sırasıyla; 17 674-36 706 mg GAE kg-1 KA ve 155.2-373.0 μmol troloks g-1 KA arasında değerler kaydedilmiştir. Tuz ve kuraklık uygulanmış genotiplerden toplam fenolik bileşik miktarlarında en fazla artışı sırasıyla 3. genotip (% 113.0) ve 2. genotip (% 113.0) gösterirken, antioksidan kapasite miktarlarında da en yüksek artış aynı genotiplerde % 133.8 ve % 96.3 değerleri ile meydana gelmiştir. Tuz uygulamaları sonrasında elde edilen sonuçlarda en yüksek değerleri her iki analiz (TFB, TEAK) için de 11. melez, kuraklık uygulamalarında ise 2. melez göstermiştir. Melezlerin tuz ve kuraklık streslerine karşı verdikleri tepkiler farklılık göstermiştir.
School District Support Structures: A Mixed Methods Study of the Leadership Development of Pre-Service School Librarians
Authors: Smith Daniella
Published: March 2022

School librarians are frequently encouraged to be leaders. However, few studies examine how pre-service school librarians can be prepared to be leaders during their librarianship degree programs. Using a mixed-methods research design and Transformational Leadership theory as a theoretical framework, the researcher studied how school district support structures provided for pre-service school librarians enrolled in a distance learning program impacted their self-perceived leadership behaviors.
The Leadership and Advocacy Roles of Hedwig Aroozoo and Her Sisters in Promoting School Librarianship in an Emerging Multilingual School System in Post-Colonial Singapore, 1960-1985
Authors: Han Lim
Published: March 2022

This historical essay reports the development of the first professional library association founded in Singapore in 1955. In the same year the first course librarianship was conducted for teachers. From 1960 to 1985 Eurasian Hedwig Aroozoo who was Director of the National Library provided School Library Services by offering bulk loans, advisory service, training and compilation of book lists, including chairing the publication of school library standards. Sister Eleanor Aroozoo promoted school libraries to the Ministry of Education and was School Library Advisor. Teacher librarian Marie Aroozoo was involved with developing school libraries and Lydia Aroozoo reporting about the National Library's mobile library visits to schools.
Certifying Celebrity in the School Library: Self-Regulated Learning in Practice
Authors: Spruce Robin , Garrison Kasey
Published: March 2022

National Board Certification is the highest level of certification and teaching recognition an educator can attain in the United States. Core foundational tenets of this process hold strong connections to inherent elements of teacher librarianship including an emphasis on monitoring and developing student's self-regulated learning. This qualitative research compares two groups of teacher librarians (one National Board Certified and one non-certified) to investigate their perceptions and practice of self-regulated learning. Findings suggest similarities within the actual teaching practices of both groups but differences in the way the participants articulate the importance of such strategies in their practice.
School Libraries in New Zealand as Technology Hubs: Enablers and Barriers to School Librarians Becoming Technology Leaders
Authors: Calvert Phillip
Published: March 2022

New Zealand government initiatives have improved the bandwidth available in schools, and new technology is increasingly incorporated in the curriculum. The possibility of the school library becoming a technology hub has been suggested. A question that has not yet been asked is whether the human resources (the school librarians) are adequate for new roles as technology leader. A survey of secondary schools in New Zealand

found that school librarians generally had good relationships with their principals and IT staff.
Where are we going? Where have we been?
Authors: Everhart Nancy
Published: March 2022

This issue is a wonderful mashup of research reports , literature reviews, research in progress and think pieces.
Constructing Youth: Reflecting on Defining Youth and Impact on Methods
Authors: Harlan Mary
Published: March 2022

In diverse fields focused on youth, researchers define and position youth as subjects differently. Debates within these disciplines can be informative. This paper engages a current debate on how youth are engaged in and isolated from the research process while still being subjects of the research. This paper is a reflection on whether we are doing research"on" youth, or rather "with" youth, and why this distinction matters.
Access and Use of Traditional and Internet Media by Secondary School Children in Mumbai, India
Authors: Yadav Akhilesh , Kharate Poonam
Published: March 2022

The purpose of this paper is to investigate the pattern of access and use of different conventional and Internet media by senior secondary students. This survey study on access and use of media by students is the first of its kind in Mumbai. The respondents were from 9th grade to 12th grade students of 4 different schools in the city. Results suggested that most of the students use Internet for searching information related to their subject

curriculum.
How Does a Policy Mean? Cultural Signifiers in the Lives of School Librarians
Authors: Mardis Marcia , Duarte Adriana
Published: March 2022

Editorial
Evidence, Standards, and School Librarianship: Prevailing Policies, Promising Methods, and Progress on a Research Agenda
Authors: Schultz-Jones Barbara , Kimmel Sue C. , Mardis Marcia A. , Jones Faye R. , Pribesh Shana , Pasquini Laura
Published: March 2022

Guided by the question, “What are the implications of national educational evidence standards for school librarianship research?,” prevailing U.S. evidence-driven educational policies are examined to identify implications for school librarianship research; promising methods to contribute to building this evidence base are explored; and finally, progress on a long-term research agenda designed to enable school librarianship researchers to contribute evidence to educational policy is reviewed. As promising methods are explored, an actionable agenda is proposed that school library researchers can undertake to participate in a causal research environment.
Building Resilience in New and Beginning Teachers: Contributions of School Librarians
Authors: Soulen Rita Reinsel , Wine Lois Diane
Published: March 2022

Building beginning teachers’ resilience may contribute to increasing teacher retention in the early years, in turn improving student academic achievement. School librarians contribute to developing teaching skills by mentoring new teachers. This qualitative study of first to third year teachers and school librarians investigated the contributions that school librarians made in building resilience of beginning teachers through a focus group of new teachers and interviews of school librarians. Findings show that school librarians may contribute to early career teacher resilience, especially during the first days of school, by encouraging perseverance, providing nourishment and empathy, and offering the library as a resource, especially for research.
The Information Literacy Continuum
Authors: Burns Elizabeth A. , Gross Melissa , Latham Don
Published: March 2022

The Association for College and Research Libraries (ACRL) and the American Association for School Libraries (AASL), two major divisions of the American Library Association (ALA), both recently released new guidelines. These documents form the basis for information literacy and library skills instruction for PK-20 education. In this study, we explored the alignment between these documents to identify the continuum of knowledge and skill expectations as well as the dispositional attributes toward information literacy that learners are presented. Our findings identified where the content of the ACRL Framework and AASL Standards Framework for Learners documents is strongly aligned as well as the gaps in the teaching and learning continuum. These findings suggest areas for ongoing development in practical application for both PK-12 school librarians and academic librarians who provide information literacy instruction in colleges and universities.
A Framework for Characterizing 21st Century School Librarianship
Authors: Phillips Abigail Leigh , Recker Mimi , Lee Victor R.
Published: March 2022

In this article, we describe a conceptual framework, called the Innovative Library Activities Framework, which helps clarify the influence of three dimensions of librarianship - sense of librarianship, resource community, and conception of library space - on the implementation of innovative library activities. The first dimension encompasses a librarian's professional identity and his/her understanding of the profession. The second dimension addresses how a librarian seeks guidance and support from a resource community for development and implementation of library services and materials. The final dimension involves a librarian's conception of the library space and place. Each dimension is closely examined, drawing evidence from data collected during observations of and interviews with participating school librarians. We conclude with implications for the profession and LIS education.
Examining the Challenges and Practices of our Russian Partners in the Institution of Teacher Librarianship
Authors: Johnston Melissa P. , Green Lucy Santos
Published: March 2022

Examining international teacher librarianship enables school library researchers and practitioners to continue uncovering the institutional factors that impact school librarianship; further strengthening the case for cross-cultural partnerships. In 2015, researchers conducted an institutional ethnography confirmatory study of school librarianship in Moscow, Russia. Emergent themes culled from previous research and confirmed in this new study were: collaboration, literacy, instruction, technology integration, and the learning environment. Confirmation of these themes in Russian school librarianship indicates teacher librarians around the world struggle with strikingly similar challenges despite varied contexts and socioeconomic situations.
Administrators' Instructional Leadership Perspective of the Role of Instructional Coaches and Teacher Librarians
Authors: Lewis Melanie A.
Published: March 2022

The purpose of this collective case study was to develop an understanding of why California K–12 public school administrators distribute instructional leadership responsibilities to either instructional coaches or teacher librarians and how the two roles compare within the context of the implementation of the California Common Core State Standards in English Language Arts (ELA/Literacy). Results demonstrated that administrators’ personal values influence their decisions to select and utilize instructional coaches or teacher librarians to provide instructional leadership. Instructional coaches are considered to be extensions of administrators as instructional leaders in ELA while teacher librarians are considered resources who may be called upon to provide occasional instructional support in ELA.
Characteristics of the immunity system in patients with pneumonia associated with COVID-19
Authors:   Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus, Bobrukevich Daria , Antonevich Natalya , Hancharou Andrei , Rynda Elena , Timokhina Oksana , Minich Yana ,   Belarusian State Medical University, Golovach Elena , Dotsenko Marina , Dotsenko Eduard
Published: March 2022

The advanced analysis of immune parameters describing differentiation profile, activation and exhaustion of lymphocytes, monocytes and granulocytes of patients with moderate and severe/critical COVID-19 pneumonia was performed.
ANTICOAGULANTES ORAIS DIRETOS EM PACIENTES COM DOENÇA VALVAR: A CONTRIBUIÇÃO DO ESTUDO RIVER
Authors:   Hospital Israelita Albert Einstein.  Diretor da Academic Research  Organization. São Paulo, SP, Brasil, Berwanger Otavio ,   SOCESP – Sociedade de  Cardiologia do Estado de São Paulo.  Coordenador do Projeto EPICO- SOCESP (Gestão 2020-2021).  Presidente do Comitê Executivo do  Estudo RIVER. São Paulo, SP, Brasil.
Published: March 2022

POR QUE DISCUTIR O ESTUDO RIVER? Como Presidente do Comitê Executivo do estudo RIVER, é um prazer discutir os resultados deste ensaio clínico randomizado,100% brasileiro, apresentado na sessão de Late Breaking Clinical Trials do congresso da American Heart Association (AHA) 2020. Os resultados principais foram publicados no New England Journal of Medicine , o que demonstra a força e a maturidade da cardiologia brasileira em gerar resultados com impacto clínico internacional. O estudo RIVER avaliou o tratamento com rivaroxabana em pacientes com fibrilação atrial e bioprótese mitral. Este foi um projeto colaborativo, liderado por um Comitê executivo acadêmico. O estudo nasceu na SOCESP e teve a égide e apoio científico desta sociedade para sua condução. As operações do estudo foram conduzidas pelo Instituto de Pesquisa do HCor. O estudo foi financiado pelo programa PROADI-SUS e pela Bayer. Descritores: Válvula Mitral; Fibrilação Atrial; Rivaroxabana
O USO DE SIMULADORES NO ENSINO DE REDES DE COMPUTADORES
Authors: Mascarenhas Dalbert Matos , Henriques Felipe Da Rocha
Published: March 2022

Este trabalho apresenta um estudo que utiliza simuladores no ensino prático de redes de computadores em cursos de graduação e técnico. Os simuladores de redes complementam o ensino diante das restrições orçamentárias para a montagem de um parque tecnológico de redes que seja próximo ao encontrado no meio empresarial. Foram utilizados três dos principais simuladores de redes de computadores existentes no trabalho. O estudo comparativo destes simuladores em práticas de laboratório é analisado e agrupado em diferentes categorias. Critérios quantitativos e qualitativos foram analisados de forma a expor as características de cada simulador e o impacto no aprendizado do aluno em diferentes momentos do seu ciclo acadêmico. Os resultados do trabalho demonstraram uma mudança na escolha dos simuladores a medida em que o aluno aumenta o grau de conhecimento prático e teórico nas disciplinas de redes de computadores. Os resultados demonstram também que a utilização dos simuladores aumenta a capacidade do aluno em lidar com os desafios tecnológicos encontrados no mercado de trabalho e também na área de pesquisa.
A QUALITATIVE AND QUANTITATIVE APPROACH ABOUT A LUDIC STRATEGY FOR TEACHING-LEARNING: THE TRIOMINOES OF GENETICS.
Authors: CLARINDO WELLINGTON , Da Conceição Suelen Ferreira , Weiss Andreia , Marçal Tiago de Souza , Ferreira Adésio
Published: March 2022

Learning is a systematic and interactive process that involves the exchange of information between pupils and teachers. The knowledge constructed during the learning process represents the basis for the cognitive, emotional and psychomotor education of the student, further contributing to the teacher's formation. Among the different subjects approached during basic education, and especially secondary school, Genetics is one that presents complex concepts, making it difficult for pupils to comprehend and therefore learn. With the aim of facilitating the process of teaching-learning the basic concepts of Genetics, the present study elaborated and applied a new ludic proposal, the game Triominoes. In this scope, Triominoes was created with 40 triangular tiles containing, on each face, complementary terms and concepts. Based on the answers to a questionnaire applied after the activity, this ludic strategy was analyzed qualitatively and quantitatively. Through these analyses, the Triominoes helped in the teaching-learning process, the development of logical-deductive reasoning, exploring the cognitive, emotional and psychomotor abilities of the learners. Therefore, Triominoes can be considered an innovative, viable and low-cost pedagogical material, which could be routinely employed for the teaching of Genetics as well as other contents from different subjects of the basic, secondary and higher education.
Optimization of the extraction conditions for Chlorophyll a from fresh Spirulina
Authors: Thao Nguyen Thi , Binh Ta Thac , Khanh Linh Pham Thi , Son Vu Hong , Minh Tu Nguyen Thi
Published: March 2022

Spirulina is a spiral cyanobacteria with simple cell structure, making it easier to extract chlorophyll than other materials. Investigation the ultrasound assisted extraction of chlorophyll a was conducted on the following factors: type of solvent, concentration of solvent, ratio of solvent: material, time and temperature. Optimization by Design Expert the extraction of chlorophyll a from spirulina algae indicates the condition to obtain the highest amount of chlorophyll a of 15.07 mg/g was as followings: solvent ethanol concentration 99.7%, ratio solvent / material: 16/1, time 2.5 hours, temperature 52°C, ultrasonic frequency 40kHz.
Enhanced Antioxidant Potential of Supplemented Yogurt with Sea Buckthorn
Authors: Khalid Faiza , Saeed Muhammad , Majeed Muhammad Rizwan , Nazir Fahid , Khalid Sundas Khalid , Amin Muhammad , Nasir Muhammad , Fatima Aman
Published: March 2022

Sea buckthorn, Hippophae rhamnoides, is a renowned fruit in Chinese traditional medicine. The plant contains a massive number of polyphenols, phytochemicals like vitamin C, flavonoids and carotenoids which act as antioxidants and effective against ailments like cold, cough, inflammation, aging and cancer. Yogurt is an ancient fermented milk product and has been using for nutritional purposes. The current study evaluated the antioxidant potential of sea buckthorn pulp (SP) and shelf life and physicochemical characteristics of supplemented yogurt with sea buckthorn. Yogurt was developed using whole milk supplemented with sea buckthorn by 0, 5, 10, 15 and 20 percent respectively. Physicochemical, phytochemical, microbial and sensory evaluation of yogurt was done at different storage period (0, 7, 14 and 21 days) and obtained data was subjected statistical design. Among 5 treatments T3 showed more acceptability levels in yogurt in terms of physicochemical phytochemical, microbial and sensory evaluation with negligible change in storage period. Negligible changes were shown of ascorbic acid, carotenoids, vitamin E, antioxidant activity and total polyphenolics contents in T3 20.65mg/g, 1.46mg/g, 12.00mg/g, 85.1% and 24.2% respectively. Microbial count of T3 remained < 10 log CFU/ml with negligible change in storage period of 21 days. T3 scored highest on the 9-point hedonic scale during the sensory evaluation as well. This research concluded that sea buckthorn can be supplemented in yogurt for utilization of its antioxidant benefits. in the search for, certification and implementation of safe natural additives. The growing demand for the so-called "clean label" foods is the driving force for many of the conducted researches in the last two decades.
Operational Effıciency and Energy Saving Analysis of Urban Transportation: The Case of Akcaray
Authors: AYDIN Zafer
Published: March 2022

Light rail systems are sustainable, energy-efficient, and eco-friendly alternatives to public transport systems that can offer solutions to increasing traffic density. As a solution to that traffic congestion, Akcaray, the first public transportation light rail system in Kocaeli, was launched by Ulasımpark in Kocaeli in 2017. In this study, operational efficiency and service level performance of 12 trams belonging to Akcaray, and 4 bus lines that interact with Akcaray route are compared with one another by Data Envelopment Analysis. It is found out that while the performance efficiency score of Akcaray is 100% in all 12 trams, it is 100% for one bus line only out of 4 busses. In addition, transportation costs, such as energy/fuel, maintenance cost, accident and environmental costs are calculated, and compared separately for both transportation options. Because Akcaray offers less energy consumption per passenger, it is calculated that USD 317,737/year can be saved, thus as a result, Akcaray consumes 1,3 million Sm3 compressed natural gas less while performing public transportation.
INFLUENCE OF THE STRIKER AND WAVEGUIDE PARAMETERS, EXTERNAL SHAPES AND INTERNAL CAVITIES OF SAMPLES FROM VARIOUS MATERIALS ON THE RESULTS OF THE WAVE DEFORMATION HARDENING (MODELING)
Authors: Kirichek Andrey , Barinov Sergey , Nikitina Lyubov' , Zaycev Aleksey
Published: March 2022

The study deals with complex effect of the external shapes and internal cavities of samples, as well as deformation waves generated in shock systems with a different ratio of striker and waveguide lengths (L1/L2=3, 5, 10), on the results of wave deformation hardening (WDH). Finite element modeling is used to conduct the research. The studies are performed on rectangular, triangular and cylindrical samples of the same thickness and volume. The influence internal cavities shapes on the hardening efficiency is evaluated by forming rectangular, triangular and cylindrical grooves of the same volume in the samples. The research was carried out using the following materials: steel 45, titanium VT 1-0, bronze BRAZH 9-4, aluminum V95. It is stated that the rectangular shape of both the product itself and the internal groove has the greatest influence on the hardening characteristics, compared with other forms under study. It is also stated that not the shape of the product itself and the cavities in it, but the parameters of the shock system such as the ratio of striker and waveguide lengths have the more significant influence on the hardening effectiveness.
THEORETICAL PREDICTION OF THE OPERATION PARAMETERS OF THE BOUNCING SNOWPLOW CUTTER DEPENDING ON THE CUTTER BAND ANGLE AND FLAKE SIZES
Authors: Aleshkov Denis , Sukovin Mikhail
Published: March 2022

The work objective is to assess the effect of cutter band angle on the power required for transporting the snow by the cutter feeder of the rotary snowplow and its performance, taking into account the interaction of snowflakes with each other.

The problem to which the paper is devoted is to find out the influence of the angle, the size of the transported particles on the productivity of the feeder cutter and the power spent on moving the snow as a group of interacting flakes of finite size.

Research methods: theoretical studies and simulation of the feeder cutter operation during transportation of snow as a group of interacting flakes of finite size.

The novelty of the work lies in the fact that simulation, for the first time, gives theoretical description of changes in the productivity of a cutter and rotary snowplow feeder of and the power costs for transporting snow depending on the cutter band angle and the typical size of snowflakes in conditions of their interaction with each other, and also approximating equations of changes in productivity and power costs depending on the cutter band angle and typical size of snowflakes.

The study results show that an increase in the cutter band angle leads to a nonlinear increase in power costs for transporting snowflakes, described by a fourth degree polynomial. An increase in the typical flake size of the transported snow in the cutter feeder of the rotary snowplow also causes a nonlinear increase in the power costs for transporting snow, which is described by a second degree polynomial. The increase in productivity with an increase in the cutter band angle is described by a fourth degree polynomial, and with an increase in the typical flake size by the third degree one. The areas of maximum power consumption and maximum productivity have an offset relative to each other in the coordinates of the typical flake size and the cutter band angle.

Conclusions: the influence of the cutter band angle and the size of transported snowflakes on the main parameters of the cutter feeder operation are defined. The results of theoretical studies correlate with the results of practical studies, which indicates the feasibility of using a mathematical model that takes into account the interaction of transported snowflakes in further studies aimed at improving the efficiency of feeder of the rotary snowplows.
Torre de Babel e Monte Sinai: modelos de exegese do Antigo Testamento
Authors: Coimbra João
Published: March 2022

“Tower of Babel and Mount Sinai: Old Testament models of biblical exegesis” is an in-depth study in Genesis 11: 1-9 and Exodus 20: 1-6. An excellent tool for those who want to know and practice the principles of Bible interpretation. The exegesis model follows three fundamental principles: literary analysis, contextual analysis and theological analysis. In literary analysis we work with the delimitation, translation of the text, comparison of versions, the structure and literary genre. In the contextual analysis we emphasize the oral tradition, the literary context of Genesis and an analysis of the socio-historical context. Three approaches were made, regarding the literary formation process, about the environment in which the text was generated and regarding the socio-historical context. In the theological analysis, the study of the correlation of the text, the analysis of the theological content and the practical context for life were carried out. In the first part, we try to answer: To what extent can one accept the text of Genesis 11.1-9 literally? How to harmonize the text with the evident phases in the process of natural language, oral and written tradition? The origin of the languages occurs at the event recorded in Genesis 11? Can the biblical event of the “Tower of Babel” be indicated as the basis for the branching out of multiple languages? Can one defend a linguistic monogenism without considering religion as an included source? Among others. In the second part, the objective is to explain the origin and the importance of monotheism for Christianity based on the exegetical research of Exodus 20.1-6. The main issue is related to the literary, historical and theological relevance to the Christian faith.
A RESILIÊNCIA COMO PRINCÍPIO EDUCATIVO PARA A TRANSFORMAÇÃO DA VIDA DO HOMEM DO CAMPO
Authors: SANTOS SILVEIRA CARDOSO SUELI DOS
Published: March 2022

O panorama educacional do Brasil e da Educação do Campo está vinculado a empasses que foram fundados ao decorrer da história; fatores que não se restringem a localização geográfica, mas elucidam um cenário de dificuldades e ao mesmo tempo de superação. Esta reflexão acerca da Educação do Campo nos incentiva a buscar meios para que o jovem agricultor tenha uma educação voltada para a sua realidade, e que estes possam ter uma participação social e política mais ativa, tendo seus direitos e deveres civis resguardados, tornando-os cidadãos resilientes, capazes de construir sua própria história e de se tornarem sujeitos protagonistas de culturas sustentáveis e de referência. A resiliência é a capacidade de transformar a realidade, superando a vivência de uma situação difícil e negativa e se fortalecer a partir destas situações adversas. A resiliência na Educação do Campo desempenha um importante papel no que se refere à flexibilidade, abertura, disponibilidade, liberdade, autonomia, responsabilidade, tolerância, ações que potencializam as relações educacionais, mas também na criação de possibilidades de ações que conduzam o estudante enquanto ser histórico capaz de reconstruir o caminhar da comunidade na qual está inserido. Assim, as leituras sobre o tema, geraram o fascínio por conhecer mais especificamente casos de resiliência na Educação do Campo partindo desta experiência em escolas rurais e de inúmeras reivindicações de professores sobre as condições necessárias para execução da proposta pedagógica nestes espaços geográficos.
Health-related quality of life and binge eating among adolescent girls with PCOS
Authors: Lidaka Lasma , Lazdane Gunta , Kivite-Urtane Anda , Gailite Linda , Dzivite-Krisane Iveta , Stokenberga Ieva
Published: March 2022

Background: Polycystic ovary syndrome (PCOS) affects 3–8% of adolescents. It is characterized by hyperandrogenism and oligoovulation/anovulation. PCOS has a negative impact on health-related quality of life (HRQoL). However, the extents to which factors influence total HRQoL of adolescents are not known. Adult PCOS patients have a higher incidence of binge eating than the general reproductive-age female population. Limited data on binge eating in adolescents with PCOS are available. Aim of this study was to investigate how PCOS and its associated factors, including binge eating, affect the HRQoL of adolescent girls. Methods: This case-control study recruited 63 adolescent girls 13–18 years of age with PCOS and 66 age-matched healthy controls. The PCOS health-related quality of life questionnaire (PCOSQ) and Binge Eating Scale (BES) were used. Multiple linear regression was executed to establish exact predictors and their effect on total HRQoL. Results: HRQoL was significantly lower in adolescents with PCOS than controls (4.9 (interquartile range (IQR) 1.5) vs. 5.8 (IQR 0.9) points). The lowest scores were found in the body hair and weight domains. BES results were not significantly higher in the PCOS group than in the control group (p = 0.727). The main predictors for total HRQoL were PCOS diagnosis per se (β = –1.002; p < 0.001), BES score (β = –0.27; p = 0.004) and body mass index (BMI) percentile (β = –0.007; p = 0.013). Conclusions: The lower HRQoL in adolescents with PCOS is attributable to the diagnosis of PCOS, BES score and BMI percentile, confirming the importance of tailoring clinical interventions and counselling to address the domains (i.e., symptoms of hirsutism and weight concerns) causing distress and lowering HRQoL. Further implementation research is required to evaluate the impact of targeted interventions on the HRQoL of adolescent girls with PCOS.
The effect of carvacrol on oxido-inflammatory ovarian injury and infertility induced by ischemia-reperfusion in rats
Authors: Sahin Nurullah , Delibas Ilhan Bahri , Isaoglu Unal , Suleyman Bahadir , Yazici Gulce Naz , Coban Taha Abdulkadir , Uzel Kemine , Suleyman Halis , Arslan Veysel
Published: March 2022

Background: Increased oxidants and proinflammatory cytokines play a role in the pathogenesis of ovarian ischemia-reperfusion (OIR) injury and related infertility. Carvacrol has antioxidant, antibacterial and anti-inflammatory properties. Methods: Protective effect of carvacrol against ischemia-reperfusion (IR)-related ovarian damage and infertility was investigated. IR process were applied to the ovaries of rats, which were divided into the following groups (n = 12): OIR, IR +50 mg/kg carvacrol (IRC-50), IR +100 mg/kg carvacrol (IRC-100) and sham group (SG). After the reperfusion process, six rats from each group were killed and the removed ovaries were examined biochemically and histopathologically. The remaining animals were kept two months with mature male rats to reproduce. Results: At a dose of 50 mg/kg, carvacrol suppressed the oxidant parameter increase and antioxidant decrease caused by IR in ovarian tissue. At a dose of 100 mg/kg, carvacrol antagonized both oxidant and proinflammatory cytokine increase and antioxidant decrease. Histopathologically, severe degeneration of follicles in the ovaries of the OIR group, necrotic cell accumulations, hemorrhage in the corpus luteum, edema in the interstitial tissue, polymorphous nuclear leukocyte (PNL) infiltration, and congestion and dilation of blood vessels were detected. Inflammatory symptoms such as edema in the ovarian tissue, congested dilated blood vessels and PNL infiltration were observed at a dose of 50 mg/kg of carvacrol, but these histopathological findings were not observed at a dose of 100 mg/kg. Conclusion: A dose of 100 mg/kg carvacrol, which eliminated inflammatory damage, significantly prevented the development of IR-induced infertility. Carvacrol may be beneficial in the treatment of IR-related ovarian damage and infertility.
Impact of Coronavirus Disease 2019 (COVID-19) on emergency department visits for ectopic pregnancies in New York City
Authors: Dabney Lisa , Karotkin Liza , Seaman Catherine , Xiang Jackie , Rozov Jaqueline , Kinsey Elizabeth , Andiman Sarah , Hardart Anne
Published: March 2022

Background: Ectopic pregnancy is a potential cause of morbidity and mortality among women and is a common diagnosis for women presenting to the emergency room. During the height of the COVID-19 pandemic in New York City (NYC) in the spring of 2020, emergency room visits for all non-COVID related health problems appeared to decrease. We examined visits for ectopic pregnancies and pregnancies of unknown location (PUL) in the emergency department (ED) of three NYC hospitals during the height of the early pandemic and compared them to the same months in the prior year. Methods: Our study is an IRB-approved retrospective chart review of all patients who presented to the ED with a positive pregnancy test during the months of March–June 2020 (pandemic period) and March–June 2019 (pre-pandemic). Demographic data, history, labs, imaging, number of visits and treatment and outcomes were measured. Results: We found that there were 324 ED visits for PUL in 2019 (pre-pandemic) compared to 195 in 2020 (pandemic). Ectopic pregnancies remained somewhat stable and were diagnosed in 59 patients in 2019 and 51 patients in 2020. The percentage of patients diagnosed with ectopic pregnancy increased from 25.1% of all patients with PUL in 2019 to 39% of all patients diagnosed with PUL in 2020. Rates of complications were similar between the two cohorts. Conclusion: Although the number of visits to the ED for PUL fell dramatically from the pre-pandemic to the pandemic time period, the number of patients actually diagnosed with ectopic pregnancy was similar between the two time periods.
Circadian Rhythms and Acute Coronary Syndrome in the Elderly
Authors: de Rueda Clemencia , Díez-Villanueva Pablo , Bonanad Clara , Alfonso Fernando
Published: March 2022

Ischemic heart disease is the leading cause of death in Western countries. The incidence, prevalence and mortality rate of acute cardiac events increase with age. Circadian rhythms allow organisms to prepare for their daily fluctuations brought on by day-night cycles, thus playing an important role in the cardiovascular physiology. This can be sometimes a double-edged sword, since exaggerated responses may not be beneficial or may be even harmful in individuals susceptible to adverse acute cardiovascular events. Remarkably, occurrence of such events has been related to a circadian pattern with a peak in the morning hours. Of interest, elderly patients seem to have an increased risk of acute coronary events, especially in the morning, though a bimodal distribution has also been observed. Further studies are required to get more insights on age-related differential circadian patterns in acute coronary syndromes patients.
Arginine Promotes the Expression of Aquaporin-3 and Water Transport in Porcine Trophectoderm Cells Through NO- and cAMP-Dependent Mechanisms
Authors: Zhu Cui , Ye Jinling , Bai Yinshan , Hu Shengdi , Tan Chengquan , Bazer Fuller W. , Johnson Gregory A. , Jiang Zongyong , Wu Guoyao
Published: March 2022

Background: Dietary supplementation with L-arginine (Arg) has been shown to increase the volume of fetal fluids in gestating swine. Aquaporins (AQPs), known as water channel proteins, are essential for embryonic growth and development. It was not known if Arg mediates water transport through AQPs in porcine conceptus trophectoderm (pTr2) cells. Methods: pTr2 cells derived from pregnant gilts on day 12 of gestation were cultured in customized Arg-free Dulbecco’s modified Eagle’s Ham medium (DMEM) supplemented with either 0.00, 0.25, or 0.50 mM Arg. Results: Arg treatment increased water transport and the expression of AQP3, which was abundantly expressed in pTr2 cells at both the mRNA and protein levels. Arg also increased the expression of iNOS and the synthesis of nitric oxide (NO) in pTr2 cells. The presence of Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME; an inhibitor of NO synthase) significantly attenuated the Arg-induced expression of AQP3. Furthermore, 0.50 mM Arg increased the concentrations of cAMP and the abundances of phosphorylated cAMP-dependent protein kinase A (PKA), phosphorylated PKA α/β/γ, and phosphorylated CREB. These effects of Arg were mimicked by Forskolin (a cell-permeable activator of adenylyl cyclase), but inhibited by H-89 (an inhibitor of cAMP-dependent protein kinase). Conclusions: The results of this study demonstrate that Arg regulates AQP3 expression and promotes water transport in pTr2 cells through NO- and cAMP-dependent signaling pathways.
All-Inside Anterior Cruciate Ligament Reconstruction: A Review of Advance and Trends
Authors: Yang Yun-tao , Cai Zi-jun , He Miao , Liu Di , Xie Wen-qing , Li Yu-sheng , Xiao Wen-feng
Published: March 2022

Anterior cruciate ligament (ACL) injury is a common disease in orthopedics and mostly occurs as a noncontact injury in athletes. Patients’ knee joint stability, which is crucial to their athletic ability, cannot be restored through conservative treatment; it can only be restored through ACLR (ACL reconstruction) surgery. The surgical techniques of ACLR are constantly evolving, from bone tendon bone (BTB) grafting combined with interface screw fixation to hamstring tendon autograft or allogeneic tendon and of suspension device constructs. In particular, the currently prevalent all-inside technique featuring good cosmetic results and quick recovery of early functions not only ensures the stable fixation of grafts but also reduces surgical trauma. This review compares the advantages and disadvantages of different aspects of all-inside ACLR, including graft selection and preparation, bone socket reconstruction, fixation methods, and surgical technique effects and limitations. It has been found that the all-inside technique excels both anatomically and clinically but still requires further development. Besides, it has some limitations, and high-quality randomized controlled trials are still required to compare the long-term effects of the all-inside technique and other ACLR techniques.
KMT2C is a Potential Biomarker of Anti-PD-1 Treatment Response in Metastatic Melanoma
Authors: Xie Kuixia , Peng Yonglin , Zhong Wenying , Liu Xinhua
Published: March 2022

Background: Metastatic melanoma (MM) represents a common malignancy with poor prognosis. Immune checkpoint inhibition (ICI), including PD-1 blockade, has been emerging as the popular therapeutic in MM for its durable treatment effect, but its response rate is still limiting. Methods: We comprehensively analyzed the associations between KMT2C somatic mutation and the tumor microenvironment as well as the ICI response of MM patients based on three published cohorts. Gene differential expression analysis between tumor samples with mutated and wild-type KMT2C was performed by DESeq2 package. Functional enrichment analysis was conducted by using clusterProfiler package. Kaplan-Meier was used to perform overall survival probability estimate through survival package and rms package was applied for the construction of nomogram model. Results: We report here that KMT2C is a potential biomarker for anti-PD-1 treatment in MM. This biomarker can be used for comprehensively analyzing its association with patients’ prognosis, tumor microenvironment and genomic features. Mutations of KMT2C profoundly altered expression of immune- and DNA replication-related genes in MM tumors. MM patients harboring KMT2C mutations showed significantly better overall survival (OS) after treatment with PD-1 monoclonal antibody as compared to wild-type KMT2C. Although KMT2C mutation has no significant influence on immune cell infiltration into MM tumors, the tumor mutation load and neoantigen load are indeed elevated in KMT2C mutated MM samples. This might represent a possible pathway through which KMT2C regulates the response of MM patients to anti-PD-1 treatment. Finally, we constructed a nomogram model by combing the independent prognostic factors, including KMT2C mutation, which could effectively predict the 1-year survival probability of MM patients after anti-PD-1 treatment. Conclusions: In conclusion, we report the role of KMT2C in anti-PD-1 treatment response regulation in MM for the first time. This may consequently be helpful for KMT2C personalized application.
Fluid Shear Stress-Induced Exosomes from Liver Cancer Cells Promote Activation of Cancer-Associated Fibroblasts via IGF2-PI3K Axis
Authors: Feng Tang , Fang Fei , Zhang Chunhe , Li Tiantian , He Jia , Shen Yang , Yu Hongchi , Liu Xiaoheng
Published: March 2022

Background: Cancer-associated fibroblasts (CAFs) are of considerable importance in tumor progression by interacting with the tumor microenvironment. However, the hidden mechanism explaining how tumor cells interact with CAFs in the tumor mechanical microenvironment remains largely unknown. Methods: We highlighted exosomes as the mediator modulating the interaction between liver cancer cells and CAFs under mechanical conditions. The normal hepatic stellate cells LX2 were exposed to the medium or exosomes from the HepG2 cells with or without fluid shear stress subjection, and the CAFs activation markers were checked. To further explore the potential role of PI3K, which is active in liver fibrosis, the PI3K inhibitor was used. Results: The specific markers of CAFs, FAP, and α-SMA, increased in LX2 with subjection to the fluid shear stress-induced exosomes from HepG2 cells. In turn, the enriched IGF2 in the exosomes activated the IGF2-PI3K signaling pathway in LX2 cells. Conclusions: These findings reveal that fluid shear stress-induced liver cancer cells possess a stronger capacity to convert normal fibroblasts to CAFs than statically cultured liver cancer cells, and tumor-derived exosomes mediated the intercellular cross-talk between liver cancer cells and fibroblasts.
Validation and Comparison of PROMISE and CONFIRM Model to Predict High-Risk Coronary Artery Disease in Symptomatic and Diabetes Mellitus Patients
Authors: Jiang Hantao , Feng Jinping , Feng Chao , Ren Pei , Ren Kai , Jin Ying , Zhou Jia
Published: March 2022

Background: The identification of high-risk coronary artery disease (HRCAD) is important in diabetes mellitus (DM) patients. However, the reliability of current models to predict HRCAD has not been fully investigated. Thus, we aimed to validate and compare CONFIRM and PROMISE high-risk model (CHM and PHM) in DM patients. Methods: 5936 symptomatic DM patients who underwent coronary computed tomographic angiography (CCTA) were identified. Probability of HRCAD for each patient was estimated based on CHM and PHM, respectively. We used Area under the receiver operating characteristic curve (AUC), integrated discrimination improvement (IDI), net reclassification improvement (NRI) and Hosmer-Lemeshow (H-L) test to evaluate model’s predictive accuracy. Results: Overall, 470 (8%) patients had HRCAD on CCTA. There was no difference between the AUC for CHM and PHM (0.744 v.s. 0.721, p = 0.0873). Compared to CHM, PHM demonstrated a positive IDI (3.08%, p < 0.0001), positive NRI (12.50%, p < 0.0001) and less discrepancy between observed and predicted probabilities (H-L χ2 for CHM: 35.81, p < 0.0001; H-L χ2 for PHM: 23.75, p = 0.0025). Conclusions: Compared to CHM, PHM was associated with a more accurate prediction for HRCAD and might optimize downstream management strategy in symptomatic patients with DM. Clinical Trial Registration: ClinicalTrials.gov (NCT04691037).
Genetic background of mitral valve prolapse
Authors: Guicciardi Nicolò Azzola , De Bonis Michele , Di Resta Chiara , Ascione Guido , Alfieri Ottavio , Maisano Francesco , Vergara Pasquale
Published: March 2022

Mitral valve prolapse (MVP) has a prevalence of 2–3% among the population. It involves a heterogeneous group of patients with different expressions and according to the phenotype can be further divided into fibroelastic deficiency, which is mainly considered as a degeneration due to aging, and myxomatous disease, frequently associated with familiar clusters. Thus, MVP can be present in syndromic, when part of a well-defined syndrome, and non-syndromic forms. The latter occurs more often. To the second belong both familiar and isolated or sporadic forms. On one hand, among familial forms, although X-linked transmission related to FLNA gene was initially identified, further studies reported also autosomal dominant mode involving MVPP genes, including DCHS1. On the other hand, genome-wide association studies (GWAS), among unrelated patients, allowed the identification of new MVP-associated genes, such as LMCD1, GLIS, and TNS1. Moreover, single nucleotide polymorphisms (SNPs) on metalloproteinase genes have been related to MVP. Interestingly some genes such as DCHS1 and DZIP1 have been reported to be involved in both familiar and isolated forms. The present review aims to illustrate the updated genetic background of MVP.
COMPUTATION OF REINSURANCE PREMIUMS BY INCORPORATING A COMPOSITE LORGNORMAL MODEL IN A RISK-ADJUSTED PREMIUM PRINCIPLE: APPLICATION TO GAM’S AUTOMOBILE INSURANCE BRANCH
Authors: Chambashi Gilbert
Published: March 2022

This paper presents a formula for calculating a reinsurance premium which has been
determined by incorporating a lognormal-burr model into a risk-adjusted premium calculating
principle called the PH-transform principle. The lognormal-burr model has been selected and
validated as the best fitting model for the used insurance data among the eight candidates of
composite lognormal models. The formula has then been applied in calculating reinsurance
premiums for an automobile insurance branch under an excess of loss non-proportional
reinsurance treaty.