bluuebunny/crossref_metadata_2025 huggingface dataset:
Willingness to Use Algorithms Varies with Social Information on Weak vs. Strong Adoption: An Experimental Study on Algorithm Aversion
Authors: Judek Jan René
Published: January 2024

The process of decision-making is increasingly supported by algorithms in a wide variety of contexts. However, the phenomenon of algorithm aversion conflicts with the development of the technological potential that algorithms bring with them. Economic agents tend to base their decisions on those of other economic agents. Therefore, this experimental approach examines the willingness to use an algorithm when making stock price forecasts when information about the prior adoption of an algorithm is provided. It is found that decision makers are more likely to use an algorithm if the majority of preceding economic agents have also used it. Willingness to use an algorithm varies with social information about prior weak or strong adoption. In addition, the affinity for technological interaction of the economic agents shows an effect on decision behavior.
Information Effect of Fintech and Digital Finance on Financial Inclusion during the COVID-19 Pandemic: Global Evidence
Authors: Ozili Peterson K. , Mhlanga David , Ammar Rym , Fersi Marwa
Published: January 2024

The lockdown restrictions during the COVID-19 pandemic led to increased interest in Fintech and digital finance solutions, and it gave people an incentive to join the formal financial sector by owning a formal account. People became interested in information about Fintech and digital finance solutions, and it led them to search the Internet to obtain information about Fintech, digital finance, and financial inclusion. In this study, we investigate whether interest in Internet information about Fintech and digital finance led to interest in Internet information about financial inclusion during the COVID-19 pandemic. Using global data that capture interest over time, we found that interest in information about Fintech was greater in developed countries while interest in information about financial inclusion was greater in developing countries during the pandemic. Interest in Fintech information was strongly correlated with interest in financial inclusion information during the pandemic. Interest in Fintech information had a significant positive effect on interest in financial inclusion information during the pandemic. There is a unidirectional causality between interest in Fintech information and interest in financial inclusion information during the pandemic. The implication of these findings is that interest in Fintech information is an important determinant of interest in financial inclusion information.
A Critical Review of Risk Assessment Models for Listeria monocytogenes in Meat and Meat Products
Authors: Gonzales-Barron Ursula , Cadavez Vasco , De Oliveira Mota Juliana , Guillier Laurent , Sanaa Moez
Published: January 2024

A review of the published quantitative risk assessment (QRA) models of L. monocytogenes in meat and meat products was performed, with the objective of appraising the intervention strategies deemed suitable for implementation along the food chain as well as their relative effectiveness. A systematic review retrieved 23 QRA models; most of them (87%) focused on ready-to-eat meat products and the majority (78%) also covered short supply chains (end processing/retail to consumption, or consumption only). The processing-to-table scope was the choice of models for processed meats such as chorizo, bulk-cooked meat, fermented sausage and dry-cured pork, in which the effects of processing were simulated. Sensitivity analysis demonstrated the importance of obtaining accurate estimates for lag time, growth rate and maximum microbial density, in particular when affected by growth inhibitors and lactic acid bacteria. In the case of deli meats, QRA models showed that delicatessen meats sliced at retail were associated with a higher risk of listeriosis than manufacture pre-packed deli meats. Many models converged on the fact that (1) controlling cold storage temperature led to greater reductions in the final risk than decreasing the time to consumption and, furthermore, that (2) lower numbers and less prevalence of L. monocytogenes at the end of processing were far more effective than keeping low temperatures and/or short times during retail and/or home storage. Therefore, future listeriosis QRA models for meat products should encompass a processing module in order to assess the intervention strategies that lead to lower numbers and prevalence, such as the use of bio-preservation and novel technologies. Future models should be built upon accurate microbial kinetic parameters, and should realistically represent cross-contamination events along the food chain.
Nash Bargaining Game Enhanced Global Malmquist Productivity Index for Cross-Productivity Index
Authors: Fallahnejad Reza , Mozaffari Mohammad Reza , Wanke Peter Fernandes , Tan Yong
Published: January 2024

The Global Malmquist Productivity Index (GMPI) stands as an evolution of the Malmquist Productivity Index (MPI), emphasizing global technology to incorporate all-time versions of Decision-Making Units (DMUs). This paper introduces a novel approach, integrating the Nash Bargaining Game model with GMPI to establish a Cross-Productivity Index. Our primary objective is to develop a comprehensive framework utilizing the Nash Bargaining Game model to derive equitable common weights for different time versions of DMUs. These weights serve as a fundamental component for cross-evaluation based on GMPI, facilitating a holistic assessment of DMU performance over varying time periods. The proposed index is designed with essential properties: feasibility, non-arbitrariness concerning the base time period, technological consistency across periods, and weight uniformity for GMPI calculations between two-time versions of a unit. This research amalgamates cross-evaluation and global technology while employing geometric averages to derive a conclusive cross-productivity index. The core motivation behind this methodology is to establish a reliable and fair means of evaluating DMU performance, integrating insights from Nash Bargaining Game principles and GMPI. This paper elucidates the rationale behind merging the Nash Bargaining Game model with GMPI and outlines the objectives to provide a comprehensive Cross-Productivity Index, aiming to enhance the robustness and reliability of productivity assessments across varied time frames.
Utilizing Massively Parallel Sequencing (MPS) of Human Leukocyte Antigen (HLA) Gene Polymorphism to Assess Relatedness in Deficiency Parentage Testing
Authors: Kouniaki Diamanto I. , Fotopoulos Konstantinos V. , Tarassi Katerina , Tsirogianni Alexandra
Published: January 2024

In the realm of DNA testing with legal implications, the reliability and precision of genetic markers play a pivotal role in confirming or negating paternity claims. This study aimed to assess the potential utility of human leukocyte antigen (HLA) gene polymorphism through massively parallel sequencing (MPS) technology as robust forensic markers for parentage testing involving genetic deficiencies. It sought to redefine the significance of HLA genes in this context. Data on autosomal short tandem repeat (aSTR) mutational events across 18 paternity cases involving 16 commonly employed microsatellite loci were presented. In instances where traditional aSTR analysis failed to establish statistical certainty, kinship determination was pursued via HLA genotyping, encompassing the amplification of 17 linked HLA loci. Within the framework of this investigation, phase-resolved genotypes for HLA genes were meticulously generated, resulting in the definition of 34 inherited HLA haplotypes. An impressive total of 274 unique HLA alleles, which were classified at either the field 3 or 4 level, were identified, including the discovery of four novel HLA alleles. Likelihood ratio (LR) values, which indicated the likelihood of the observed data under a true biological relationship versus no relationship, were subsequently calculated. The analysis of the LR values demonstrated that the HLA genes significantly enhanced kinship determination compared with the aSTR analysis. Combining LR values from aSTR markers and HLA loci yielded conclusive outcomes in duo paternity cases, showcasing the potential of HLA genes and MPS technology for deeper insights and diversity in genetic testing. Comprehensive reference databases and high-resolution HLA typing across diverse populations are essential. Reintegrating HLA alleles into forensic identification complements existing markers, creating a potent method for future forensic analysis.
Danmei and/as Fanfiction: Translations, Variations, and the Digital Semiosphere
Authors: Lowe JSA
Published: January 2024

Since the late 1990s, Chinese internet publishing has seen a surge in literary production in terms of danmei, which are webnovels that share many of the features of Anglophone fanfiction. Thanks in part to recent live-action adaptations, there has been an influx of new Western and Chinese diaspora readers of danmei. Juxtaposing these bodies of literature in English in particular enables us to examine the complexities of how danmei are newly circulating in the Anglophone world and have become available themselves for transformative work, as readers also write fanfiction based on danmei. This paper offers a comparative reading of the following three such texts, which explore trauma recovery through the arc of romance: Tianya Ke, a danmei novel by Priest; Notebook No. 6 by magdaliny, a novella-length piece of fanfiction based on Marvel characters; and orange_crushed’s Strays, a fanfiction based on the live-action drama that was, in turn, based on Tianya Ke. The space described by Lotman’s semiosphere offers an additional model in which these texts reflect on one another; furthermore, along the porous digital border between fanfiction, danmei in translation, and fan novels based on danmei, readers and writers negotiate and vex contemporary culture.
Development and Validation of the Attitudes towards Social Robots Scale
Authors: Niewrzol Daniel B. , Ostermann Thomas
Published: January 2024

The idea of artificially created social robots has a long tradition. Today, attitudes towards robots play a central role in the field of healthcare. Our research aimed to develop a scale to measure attitudes towards robots. The survey consisted of nine questions on attitudes towards robots, sociodemographic questions, the SWOP-K9, measuring self-efficacy, optimism, and pessimism, and the BFI-10, measuring personality dimensions. Structural relations between the items were detected using principal components analysis (PCA) with Varimax rotation. Correlations and Analysis of Variance were used for external validation. In total, 214 participants (56.1% female, mean age: 30.8 ± 14.4 years) completed the survey. The PCA found two main components, “Robot as a helper and assistant” (RoHeA) and “Robot as an equal partner” (RoEqP), with four items each explaining 53.2% and 17.5% of the variance with a Cronbach’s α of 0.915 and 0.768. In the personality traits, “Conscientiousness” correlated weakly with both subscales and “Extraversion” correlated with RoHeA, while none the subscales of the SWOP-K9 significantly correlated with RoEqP or RoHeA. Male participants scored significantly higher than female participants. Our survey yielded a stable and convergent two-factor instrument that exhibited convincing validity and complements other findings in the field. The ASRS can easily be used to describe attitudes towards social robots in human society. Further research, however, should be carried out to investigate the discriminant and convergent validity of the ASRS.
Different Mechanisms in Doxorubicin-Induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations
Authors: Nguyen Hien C. , Frisbee Jefferson C. , Singh Krishna K.
Published: January 2024

Germline mutations in Breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2) cause breast, ovarian, and other cancers, and the chemotherapeutic drug doxorubicin (Dox) is widely used to treat these cancers. However, Dox use is limited by the latent induction of severe cardiotoxicity known as Dox-induced cardiomyopathy, for which there are no specific treatments currently available. Dox is administered into the systemic circulation, where it readily translocates into sub-cellular compartments and disrupts the integrity of DNA. Accumulating evidence indicates that oxidative stress, DNA damage, inflammation, and apoptosis all play a central role in Dox-induced cardiomyopathy. The BRCA1 and BRCA2 proteins are distinct as they perform crucial yet separate roles in the homologous recombination repair of DNA double-strand breaks, thereby maintaining genomic integrity. Additionally, both BRCA1 and BRCA2 mitigate oxidative stress and apoptosis in both cardiomyocytes and endothelial cells. Accordingly, BRCA1 and BRCA2 are essential regulators of pathways that are central to the development of cardiomyopathy induced by Doxorubicin. Despite extensive investigations, there exists a gap in knowledge about the role of BRCA1 and BRCA2 in Doxorubicin-induced cardiomyopathy. Here, we review the previous findings and associations about the expected role and associated mechanisms of BRCA1 and 2 in Dox-induced cardiomyopathy and future perspectives.
Rapid Construction and Application of a Vector for Tobacco Ringspot Virus-Induced McPDS Silencing in Bitter Gourd
Authors: Zeng Lingen , Zhang Hui , Guo Jinju , Deng Zhijun , Liu Hongbiao , Du Hu , Zhong Yujuan , Zhang Changyuan , Yao Chunpeng
Published: January 2024

The aim of this study is to facilitate the construction of virus-induced gene silencing vectors and to provide a reference or positive control for gene silencing in bitter gourd. A recombinant TRSV (tobacco ringspot virus) containing two components, pTRSV1 and pTRSV2, was used in this study. The fragment of the McPDS target was cloned into pTRSV2 via combined enzymic ligation during digestion. The TRSV components were agro-infiltrated into tobacco leaves to grow virus particles, which were then extracted and mechanically inoculated into the bitter gourd plants. The effect of TRSV-McPDS-mediated McPDS gene silencing was evaluated by observing the photo-bleaching phenotype, detecting the TRSV virus, and quantifying the downregulation of MCPDS gene expression and chlorophyll contents. The results showed that all bitter gourd plants infected with the empty TRSV or TRSV-McPDS virus grew and developed normally, with no visible signs of viral disease. However, after seven days of inoculation, only the bitter gourd plants that were inoculated with TRSV-McPDS showed obvious photobleaching in the leaves, stems, and buds. The TRSV-specific fragments were tested out in the systemically infected leaves of bitter gourd. The transcription level of the McPDS gene in the leaves dropped by 84.7%. The chlorophyll content also dropped significantly. These data suggest that the rapidly constructed VIGS vector TRSV-McPDS successfully induced McPDS silencing in bitter gourd. Taken together, the results of this study provide a practical method for vector construction in various VIGS applications, as well as a reference and a positive control for TRSV-induced gene silencing in bitter gourd.
Hydrodynamic Modeling for Flow and Velocity Estimation from an Arduino Ultrasonic Sensor
Authors: Pereira Tatiane Souza Rodrigues , de Carvalho Thiago Pires , Mendes Thiago Augusto , Reis Guilherme da Cruz dos , Formiga Klebber Teodomiro Martins
Published: January 2024

Flow is a crucial variable in water resources, although its determination is challenging. Rating curves are standard but have conceptual limitations, leading to significantly high uncertainties. Hydrodynamic models offer a more precise alternative, but they necessitate continuous measurements of velocities, which are complex and expensive to obtain. Thus, this article aimed to validate a hydrodynamic model that estimates flows and velocities in transient conditions based on water levels measured using a low-cost ultrasonic sensor. The results indicated that these estimates can be reliable if (1) hydrodynamic models are used to represent the flow, (2) the channel bed slope is well represented in the geometric data, and (3) Manning’s coefficients are accurately estimated during calibration. The calculated flow and velocity showed a maximum variation of 40% for the same water level compared to estimates using the rating curve. The model exhibited higher sensitivity in terms of the flow when varying the channel bed slope, highlighting the importance of topographic surveys for the estimates. The validity of the implemented model was assessed with experimental data, indicating precision and reliability for practical applications in natural channels.
Role of Mn-LIPA in Sex Hormone Regulation and Gonadal Development in the Oriental River Prawn, Macrobrachium nipponense
Authors: Cai Pengfei , Zhang Wenyi , Jiang Sufei , Xiong Yiwei , Qiao Hui , Yuan Huwei , Gao Zijian , Zhou Yongkang , Jin Shubo , Fu Hongtuo
Published: January 2024

This study investigates the role of lysosomal acid lipase (LIPA) in sex hormone regulation and gonadal development in Macrobrachium nipponense. The full-length Mn-LIPA cDNA was cloned, and its expression patterns were analyzed using quantitative real-time PCR (qPCR) in various tissues and developmental stages. Higher expression levels were observed in the hepatopancreas, cerebral ganglion, and testes, indicating the potential involvement of Mn-LIPA in sex differentiation and gonadal development. In situ hybridization experiments revealed strong Mn-LIPA signaling in the spermatheca and hepatopancreas, suggesting their potential role in steroid synthesis (such as cholesterol, fatty acids, cholesteryl ester, and triglycerides) and sperm maturation. Increased expression levels of male-specific genes, such as insulin-like androgenic gland hormone (IAG), sperm gelatinase (SG), and mab-3-related transcription factor (Dmrt11E), were observed after dsMn-LIPA (double-stranded LIPA) injection, and significant inhibition of sperm development and maturation was observed histologically. Additionally, the relationship between Mn-LIPA and sex-related genes (IAG, SG, and Dmrt11E) and hormones (17β-estradiol and 17α-methyltestosterone) was explored by administering sex hormones to male prawns, indicating that Mn-LIPA does not directly control the production of sex hormones but rather utilizes the property of hydrolyzing triglycerides and cholesterol to provide energy while influencing the synthesis and secretion of self-sex hormones. These findings provide valuable insights into the function of Mn-LIPA in M. nipponense and its potential implications for understanding sex differentiation and gonadal development in crustaceans. It provides an important theoretical basis for the realization of a monosex culture of M. nipponense.
Thymic-Epithelial-Cell-Dependent Microenvironment Influences Proliferation and Apoptosis of Leukemic Cells
Authors: Patel Sandesh Kumar , Zhdanovskaya Nadezda , Sergio Ilaria , Cardinale Antonella , Rosichini Marco , Varricchio Claudia , Pace Eleonora , Capalbo Carlo , Locatelli Franco , Macone Alberto , Velardi Enrico , Palermo Rocco , Felli Maria Pia
Published: January 2024

T-cell acute lymphoblastic leukemia (T-ALL) is a hematological cancer characterized by the infiltration of immature T-cells in the bone marrow. Aberrant NOTCH signaling in T-ALL is mainly triggered by activating mutations of NOTCH1 and overexpression of NOTCH3, and rarely is it linked to NOTCH3-activating mutations. Besides the known critical role of NOTCH, the nature of intrathymic microenvironment-dependent mechanisms able to render immature thymocytes, presumably pre-leukemic cells, capable of escaping thymus retention and infiltrating the bone marrow is still unclear. An important challenge is understanding how leukemic cells shape their tumor microenvironment to increase their ability to infiltrate and survive within. Our previous data indicated that hyperactive NOTCH3 affects the CXCL12/CXCR4 system and may interfere with T-cell/stroma interactions within the thymus. This study aims to identify the biological effects of the reciprocal interactions between human leukemic cell lines and thymic epithelial cell (TEC)-derived soluble factors in modulating NOTCH signaling and survival programs of T-ALL cells and TECs. The overarching hypothesis is that this crosstalk can influence the progressive stages of T-cell development driving T-cell leukemia. Thus, we investigated the effect of extracellular space conditioned by T-ALL cell lines (Jurkat, TALL1, and Loucy) and TECs and studied their reciprocal regulation of cell cycle and survival. In support, we also detected metabolic changes as potential drivers of leukemic cell survival. Our studies could shed light on T-cell/stroma crosstalk to human leukemic cells and propose our culture system to test pharmacological treatment for T-ALL.
Altered Levels of Natural Autoantibodies against Heat Shock Proteins in Pregnant Women with Hashimoto’s Thyroiditis
Authors: Simon Diána , Erdő-Bonyár Szabina , Böröcz Katalin , Balázs Noémi , Badawy Ahmed , Bajnok Anna , Nörenberg Jasper , Serény-Litvai Tímea , Várnagy Ákos , Kovács Kálmán , Hantosi Eszter , Mezősi Emese , Németh Péter , Berki Tímea
Published: January 2024

The function of natural autoantibodies (nAAbs) in maintaining immunological tolerance has been comprehensively explained; however, their function in pregnant patients dealing with autoimmune diseases has not been thoroughly investigated. As Hashimoto’s thyroiditis (HT) is the predominant organ-specific autoimmune condition of women of childbearing age, this study’s objective was to evaluate IgM and IgG nAAbs targeting mitochondrial citrate synthase (CS) and heat shock proteins (Hsp60 and Hsp70) in women diagnosed with HT who were pregnant (HTP). Serum samples collected from HTP and healthy pregnant (HP) women in the first and third trimesters were tested using in-house-developed enzyme-linked immunosorbent assays (ELISAs). Our findings indicate the stability of nAAbs against CS and Hsps throughout the pregnancies of both healthy women and those with HT. However, during both trimesters, HTP patients displayed elevated levels of IgM isotype nAAbs against Hsp60 and Hsp70 compared to HP women, suggesting a regulatory role of IgM nAAbs during the pregnancies of patients with HT. Nonetheless, levels of IgG isotype nAAbs against Hsps were lower solely in the third trimester among HTP patients, resulting in a higher IgM/IgG ratio, which indicates their importance in alterations of the nAAb network during pregnancy in patients with HT.
Inhibitory Effect of a Tankyrase Inhibitor on Mechanical Stress-Induced Protease Expression in Human Articular Chondrocytes
Authors: Hotta Yoshifumi , Nishida Keiichiro , Yoshida Aki , Nasu Yoshihisa , Nakahara Ryuichi , Naniwa Shuichi , Shimizu Noriyuki , Ichikawa Chinatsu , Lin Deting , Fujiwara Tomohiro , Ozaki Toshifumi
Published: January 2024

We investigated the effects of a Tankyrase (TNKS-1/2) inhibitor on mechanical stress-induced gene expression in human chondrocytes and examined TNKS-1/2 expression in human osteoarthritis (OA) cartilage. Cells were seeded onto stretch chambers and incubated with or without a TNKS-1/2 inhibitor (XAV939) for 12 h. Uni-axial cyclic tensile strain (CTS) (0.5 Hz, 8% elongation, 30 min) was applied and the gene expression of type II collagen a1 chain (COL2A1), aggrecan (ACAN), SRY-box9 (SOX9), TNKS-1/2, a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5), and matrix metalloproteinase-13 (MMP-13) were examined by real-time PCR. The expression of ADAMTS-5, MMP-13, nuclear translocation of nuclear factor-κB (NF-κB), and β-catenin were examined by immunocytochemistry and Western blotting. The concentration of IL-1β in the supernatant was examined by enzyme-linked immunosorbent assay (ELISA). TNKS-1/2 expression was assessed by immunohistochemistry in human OA cartilage obtained at the total knee arthroplasty. TNKS-1/2 expression was increased after CTS. The expression of anabolic factors were decreased by CTS, however, these declines were abrogated by XAV939. XAV939 suppressed the CTS-induced expression of catabolic factors, the release of IL-1β, as well as the nuclear translocation of NF-κB and β-catenin. TNKS-1/2 expression increased in mild and moderate OA cartilage. Our results demonstrated that XAV939 suppressed mechanical stress-induced expression of catabolic proteases by the inhibition of NF-κB and activation of β-catenin, indicating that TNKS-1/2 expression might be associated with OA pathogenesis.
Nursing Honeybee Behavior and Sensorial-Related Genes Are Altered by Deformed Wing Virus Variant A
Authors: Diego Silva , Nolberto Arismendi , Pablo Alveal Juan , Ricardo Ceballos , Nelson Zapata , Marisol Vargas
Published: January 2024

Insect behavior is coordinated mainly by smell through the diverse odor-binding proteins (OBP) that allow them to identify and recognize their environment. Sensory information collected through smell is then analyzed and interpreted in the brain, allowing for correct insect functioning. The behavior of honeybees (Apis mellifera L.) can be affected by different pathogens, such as deformed wing virus (DWV). In particular, the DWV variant A (DWV-A) is capable of altering olfactory sensitivity and reducing the gene expression of different OBPs, including those associated with nursing behavior. The DWV is also capable of replicating itself in the sensory lobes of the brain, further compromising the processing of sensory information. This study evaluated the behavioral response of nurse honeybees exposed to a pheromone compound and the alterations in the gene expression of the pre- and post-synaptic neuronal genes neuroxins-1 and neurogilin-1 in the bee heads and OBP proteins in the antennae of nurse bees inoculated with DWV-A. The behavioral response of nurse bees exposed to the larval pheromone compound benzyl alcohol was analyzed using a Y-tube olfactometer. The viral load, the gene expression of OBP5 and OBP11 in antennae, and neuroxins-1 and neurogilin-1 in the bee heads were analyzed via qPCR. High viral loads significantly reduced the ability of 10- and 15-day-old nurse honeybees to choose the correct pheromone compound. Also, the gene expression of OBP5, OBP11, neuroxin-1, and neurogilin-1 in nurse honeybees decreased when they were highly infected with DWV-A. These results suggest that a DWV-A infection can disturb information processing and cause nursing honeybees to reduce their activity inside the hive, altering internal cohesion.
Adverse Events Requiring Hospitalization Following Catheter Ablation for Atrial Fibrillation in Heart Failure with versus without Systolic Dysfunction
Authors: Kataoka Naoya , Imamura Teruhiko , Koi Takahisa , Uchida Keisuke , Kinugawa Koichiro
Published: January 2024

Background: The safety and efficacy of atrial fibrillation (AF) ablation in individuals with heart failure (HF) with preserved ejection fraction (EF), particularly concerning the occurrence of post-procedural adverse events necessitating hospitalization, including anticoagulant-associated major bleeding, still lack conclusive determination. Methods: Data from patients with HF and AF who underwent catheter ablation for AF between 2019 and 2022 at our institution were retrospectively reviewed. All participants were divided into an EF < 50% group or an EF ≥ 50% group according to their baseline left ventricular EF. The composite incidence of the clinical events following catheter ablation was compared between the two groups: (1) all-cause death, (2) HF hospitalization, (3) stroke or systemic embolism, and (4) major bleeding. Results: A total of 122 patients (75 years old, 68 male) were included. Of them, 62 (50.8%) patients had an EF ≥ 50%. EF ≥ 50% was an independent predictor of the composite endpoint (adjusted odds ratio 6.07, 95% confidence interval 1.37–26.99, p = 0.018). The incidences of each adverse event were not significantly different between the two groups, except for a higher incidence of major bleeding in the EF ≥ 50% group (12.7% vs. 0%, p = 0.026). Conclusions: Among patients with HF coupled with AF, the incidence of adverse events following AF ablation proved notably elevated in patients with EF ≥ 50% in contrast to their counterparts with EF < 50%. This disparity primarily stems from a heightened occurrence of major bleeding within the EF ≥ 50% cohort. The strategy to reduce adverse events, especially in patients with EF ≥ 50%, remains the next concern.
Effectiveness and Safety of the Intermittently Scanned Continuous Glucose Monitoring System FreeStyle Libre 2 in Patients with Type 2 Diabetes Treated with Basal Insulin or Oral Antidiabetic Drugs: An Observational, Retrospective Real-World Study
Authors: Conti Matteo , Massari Giulia , Meneghini Elena , Pasquino Bernadetta , Agosti Barbara , Chinotti Federica , Pintaudi Basilio , Girelli Angela , Bertuzzi Federico
Published: January 2024

Intermittently Scanned Continuous Glucose Monitoring (isCGM) devices are increasingly being used in patients with type 2 diabetes mellitus (T2DM) on insulin therapy for their benefits regarding disease management. Evidence of isCGM use in patients with T2DM on basal or non-insulin therapy is lacking. This study aimed at assessing the efficacy and safety of isCGM in this population. This was an observational, retrospective, real-world study enrolling patients with T2DM who were starting the use of isCGM. Data from medical records (i.e., demographics, clinical characteristics, laboratory assessments, and isCGM metrics) were collected over three time periods (baseline, 3 and 6 months). The endpoints were glycated haemoglobin (HbA1c) changes and changes in isCGM metrics as defined by the International Consensus from baseline to 3 months and 6 months. Overall, 132 patients were included (69.5% male; mean age 68.2 ± 11.0 years; mean disease duration 19.0 ± 9.4 years; 79.7% on basal insulin ±non-insulin therapy; mean baseline HbA1c 8.1% ± 1.3%). The estimated mean change in HbA1c was statistically significant at three (−0.4 ± 1.0%; p = 0.003) and six months (−0.6 ± 1.3%; p < 0.0001). In conclusion, isCGM proved to be effective and safe in improving glycaemic control in patients with T2DM on basal insulin or non-insulin therapy.
Middle Molecular Uremic Toxin and Blood Purification Therapy
Authors: Kawanishi Hideki
Published: January 2024

The purpose of blood purification therapy is to remove uremic toxins, and middle molecules (MMs) are a specific target. An MM is defined as a solute that passes through the glomerulus with a molecular weight in the range of 0.5–58 kDa, and new classifications of “small-middle 0.5–15 kDa,” “medium-middle 15–25 kDa,” and “large-middle 25–58 kDa” were proposed. In Japan, the removal of α1-microglobulin (αMG) in the large-middle range has been the focus, but a new theory of removal has been developed, emphasizing the antioxidant effect of αMG as a physiological function. Clinical proof of this mechanism will lead to further development of blood purification therapies.
Embolization of De Novo Pulmonary Arteriovenous Malformations Using High-Volume Detachable Non-Fibered Coils: Propensity-Matched Comparison to Traditional Coils
Authors: Mathevosian Sipan , Sparks Hiro , Cusumano Lucas , Roberts Dustin , Majumdar Shamaita , McWilliams Justin
Published: January 2024

Embolization of de novo pulmonary arteriovenous malformations (PAVMs) using high-volume detachable non-fibered (HVDNF) coils was compared to traditional non-HVDNF coils. Persistent-occlusion rates were evaluated. A total of 272 de novo (previously untreated) PAVM treatments were retrospectively stratified into those treated with non-HVDNF coils only (n = 192) and those treated with HVDNF coils with or without other coils (n = 80). Propensity score matching, followed by survival analysis and cost analysis, was performed. The overall persistent-occlusion rate was 86.0% (234/272). Persistent occlusion was achieved in 81.8% of PAVMs using non-HVDNF coils, compared with 96.3% using HVDNF coils (p = 0.0017). The mean follow-up was 30.7 ± 31.9 months versus 14.7 ± 13.4 months, respectively (p < 0.0001). Propensity-matched survival analysis demonstrated PAVMs treated with HVDNF coils recurred significantly less frequently than PAVMs treated with non-HVNDF coils (p = 0.023). The use of HVDNF coils was more expensive than standard coils, however not significantly different for the treatment of complex PAVMs. The use of high-volume detachable non-fibered coils was associated with higher persistent-occlusion rates when compared with non-HVDNF coils. HVDNF coils were more expensive on average; however, cost was similar between groups for the treatment of complex PAVMs.
Impact of Coronavirus Disease 2019 (COVID-19) Pandemic on Surgical Site Infection in Patients with Inflammatory Bowel Disease—A Monocentric, Retrospective Cohort Study
Authors: Strobel Rahel Maria , Baehr Amelie , Hammerich Ralf , Schulze Daniel , Lehmann Kai Siegfried , Lauscher Johannes Christian , Beyer Katharina , Otto Susanne Dorothea , Seifarth Claudia
Published: January 2024

(1) Background: Surgical site infections (SSIs) are a relevant problem with a 25% incidence rate after elective laparotomy due to inflammatory bowel disease (IBD). The aim of this study was to evaluate whether stricter hygienic measures during the COVID-19 pandemic influenced the rate of SSI. (2) Methods: This is a monocentric, retrospective cohort study comparing the rate of SSI in patients with bowel resection due to IBD during COVID-19 (1 March 2020–15 December 2021) to a cohort pre-COVID-19 (1 February 2015–25 May 2018). (3) Results: The rate of SSI in IBD patients with bowel resection was 25.8% during the COVID-19 pandemic compared to 31.8% pre-COVID-19 (OR 0.94; 95% CI 0.40–2.20; p = 0.881). There were seventeen (17.5%) superficial and four (4.1%) deep incisional and organ/space SSIs, respectively, during the COVID-19 pandemic (p = 0.216). There were more postoperative intra-abdominal abscesses during COVID-19 (7.2% vs. 0.9%; p = 0.021). The strictness of hygienic measures (mild, medium, strict) had no influence on the rate of SSI (p = 0.553). (4) Conclusions: Hygienic regulations in hospitals during COVID-19 did not significantly reduce the rate of SSI in patients with bowel resection due to IBD. A ban on surgery, whereby only emergency surgery was allowed, was likely to delay surgery and exacerbate the disease, which probably contributed to more SSIs and postoperative complications.
A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis
Authors: Pena-Verdeal Hugo , Garcia-Queiruga Jacobo , Sabucedo-Villamarin Belen , Garcia-Resua Carlos , Giraldez Maria J. , Yebra-Pimentel Eva
Published: January 2024

(1) Background: Dry eye disease (DED) is a chronic ocular surface condition that requires precise diagnostic tools. The present study aimed to investigate the diagnostic potential of the absolute inter-eye difference (|OD-OS|) in tear meniscus height (TMH) for the detection of the presence of aqueous deficient dry eye (ADDE). (2) Methods: A sample of 260 participants with dry eye complaints underwent ocular surface examinations thorough diagnostic assessments based on the Tear Film and Ocular Surface Society guidelines (TFOS DEWS II). Participants were subsequently categorized as No ADDE and ADDE based on TMH. Statistical analyses to determine the optimal TMH|OD-OS| cut-off value in a randomly selected study group (200 participants) were performed, while a separate validation analysis of the cut-off value obtained in a random cross-validation group (60 participants) was also performed. (3) Results: The significant diagnostic capability of TMH|OD-OS| (area under the curve = 0.719 ± 0.036, p < 0.001) was found. The identified cut-off value of 0.033 mm demonstrated reliable specificity (77.6%) and moderate sensitivity (59.1%). Cross-validation confirmed the cut-off value’s association with the TFOS DEWS II diagnostic criterion (Cramer’s V = 0.354, p = 0.006). (4) Conclusions: The present study provides evidence for the diagnostic potential of TMH|OD-OS| in identifying ADDE. The identified cut-off value enhances the specificity and offers moderate sensitivity, providing an objective tool for clinical decision making.
Characterization of Interlaminar Friction during the Forming Processes of High-Performance Thermoplastic Composites
Authors: Campos Daniel , Maimí Pere , Martín Alberto
Published: January 2024

Friction is a pivotal factor influencing wrinkle formation in composite material shaping processes, particularly in novel thermoplastic composites like polyetheretherketone (PEEK) and low-melting polyaryletherketone (LM-PAEK) matrices reinforced with unidirectional carbon fibers. The aerospace sector lacks comprehensive data on the behavior of these materials under forming conditions, motivating this study’s objective to characterize the interlaminar friction of such high-performance thermoplastic composites across diverse temperatures and forming parameters. Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) were employed to analyze the thermomechanical behaviors of PEEK and LM-PAEK. These data guided friction tests covering room-to-forming temperatures. Horizontal pull-out fixed-plies tests were conducted to determine the friction coefficient and shear stress dependency concerning temperature, pressure, and pulling rate. Below the melting point, both materials adhered to Coulomb’s law for friction behavior. However, above the melting temperature, PEEK’s friction decreased while LM-PAEK’s friction increased with rising temperatures. These findings highlight the distinct responses of these materials to temperature variations, pulling rates, and pressures, emphasizing the need for further research on friction characterization around glass transition and melting temperatures to enhance our understanding of this phenomenon.
An Interpretation of Landscape Preferences Based on Geographic and Social Media Data to Understand Different Cultural Ecosystem Services
Authors: Yang Yuanting , Duan Wei
Published: January 2024

A crucial component of ecosystem services (ES) that represents social and humanities values is the cultural ecosystem service (CES), which refers to the non-material advantages that the environment provides for humans. CES are challenging to deeply understand, and little is known about the interactions between CES and landscape variables, particularly in some remote Chinese cities. In order to assess the dominant landscape variables of different CESs from physical, experiential, intellectual and inspirational aspects, this article investigates the landscape variables that may influence the public preferences of various CESs based on social media and geographic data in Anshun, China. The findings are displayed below. The public preferences of various CESs are impacted by the landscape variables in different ways. Physical CESs are influenced by both natural and infrastructure elements, demonstrating that accessibility to restaurants, accommodation, and transit affects how people interact with plays in public. Experiential CESs are primarily influenced by sensory elements, particularly the visual senses, suggesting that when people visit such settings, they place more emphasis on sensory experiences. Intellectual CESs are mostly affected by sensory and natural elements, implying that intellectual CESs with a natural perception are more alluring to tourists. Inspirational CESs are mainly influenced by natural and infrastructure elements, people usually consider nature and convenience when they go to such scenic spots. From the standpoint of promoting people’s wellbeing and boosting tourism appeal, the study’s results can offer fresh perspectives and content additions for the tourism landscape planning and management in Anshun.
The *t-V-ce System of the Carib Languages and the Kuikuro Resultative Participle
Authors: Dos Santos Gelsama Mara Ferreira , Franchetto Bruna
Published: January 2024

In the Kuikuro language (Upper Xingu Carib), the construction tü-/ t-verb-i/-ti/-si/-stress is a reflex of the Carib proto-construction *t-V-ce, often labeled as a ‘participle’. It is a morphological form composed of a prefix and a set of allomorphic suffixes that attach to transitive, intransitive, transitivized, or detransitivized verb stems. In this paper, the construction tü-/ t-verb-i/-ti/-si/-stress is described and analyzed as a resultative denoting a grammatically represented result of an event that is the background of a subsequent foregrounded event. We argue that, in Kuikuro, the participial verb inflection has aspectual value and we define the construction tü-/ t-verb-i/-ti/-si/-stress as participial resultative aspect. Unlike in English, in Kuikuro, an ergative language, the resultative participial forms of transitive and transitivized verb stems license their external arguments. A description of the morphosyntax, semantics, and uses of Kuikuro participial forms precedes a final theoretically based approach that departs from Embick’s analysis of English participles. Our proposal for the analysis of the resultative participles in Kuikuro emphasizes the importance of this phenomenon for a comparison inside the Carib family and for ergative languages regarding the relationship between transitive resultative participles and ergativity.
Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy
Authors: Kou Erwen , Zhang Xiaobei , Dong Baiping , Wang Bo , Zhu Yuanjie
Published: January 2024

Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders. Notably, histamine H1 and H2 receptor antagonists have been extensively investigated and universally acknowledged as recommended treatment agents for numerous allergic diseases and acid-related disorders, respectively. Historically, the combination of H1 and H2 receptor antagonists has been considered a classic treatment strategy, demonstrating relatively superior efficacy compared with single-drug therapies in the treatment of diverse histamine-mediated diseases. The latest emerging studies have additionally suggested the underlying roles of histamine and H1R and H2R in the development of anxiety disorders, arthritic diseases, and postexercise hypotension. Nevertheless, there is still a lack of systematic reviews on the clinical efficacy of combination therapy, greatly limiting our understanding of its clinical application. Here, we present a comprehensive overview of the current knowledge and perspectives regarding the combination of H1 and H2 histamine receptor antagonists in various histamine-mediated disorders. Furthermore, we critically analyze the adverse effects and limitations associated with combination therapy while suggesting potential solutions. Our review can offer a systematic summary and promising insights into the in-depth and effective application of the combination of H1 and H2 receptor antagonists.
Artificial Intelligence in Obstetric Anomaly Scan: Heart and Brain
Authors: Enache Iuliana-Alina , Iovoaica-Rămescu Cătălina , Ciobanu Ștefan Gabriel , Berbecaru Elena Iuliana Anamaria , Vochin Andreea , Băluță Ionuț Daniel , Istrate-Ofițeru Anca Maria , Comănescu Cristina Maria , Nagy Rodica Daniela , Iliescu Dominic Gabriel
Published: January 2024

Background: The ultrasound scan represents the first tool that obstetricians use in fetal evaluation, but sometimes, it can be limited by mobility or fetal position, excessive thickness of the maternal abdominal wall, or the presence of post-surgical scars on the maternal abdominal wall. Artificial intelligence (AI) has already been effectively used to measure biometric parameters, automatically recognize standard planes of fetal ultrasound evaluation, and for disease diagnosis, which helps conventional imaging methods. The usage of information, ultrasound scan images, and a machine learning program create an algorithm capable of assisting healthcare providers by reducing the workload, reducing the duration of the examination, and increasing the correct diagnosis capability. The recent remarkable expansion in the use of electronic medical records and diagnostic imaging coincides with the enormous success of machine learning algorithms in image identification tasks. Objectives: We aim to review the most relevant studies based on deep learning in ultrasound anomaly scan evaluation of the most complex fetal systems (heart and brain), which enclose the most frequent anomalies.
Prediction of the Physical-Mechanical Properties of Roller-Compacted Concrete Pavements under Different Service and Mix Conditions Based on Cement and Water Content
Authors: Pulecio-Díaz Julián , Sol-Sánchez Miguel , Moreno-Navarro Fernando
Published: January 2024

Roller-compacted concrete (RCC) for pavements has experienced problems with its physical-mechanical performance over extended periods due to ambient and in situ curing conditions. Accordingly, this study aimed to present multiple regression equations for calculating the physical-mechanical properties of RCC for pavements under different service and mix conditions. For this purpose, the research included two cement and two water contents, one reduced with admixture, and four combinations of temperature and relative humidity. For model calibration and definition of the equations, cubic and beam samples were fabricated to carry out physical-mechanical tests, such as moisture content, shrinkage, and modulus of rupture. Laboratory-obtained data were studied with the Response Surface Methodology (RSM) to determine the best regression equations. The main findings determined that the behavior of a mixture of RCC at a prolonged ambient exposure time is possible because the surface models and the RSM were consistent with the different service and mix conditions. The models showed an accuracy of 98.99% in detecting shrinkage changes from 12 to 16% cement with 5.65% water in dry to wet ambient conditions. Similarly, moisture content and modulus of rupture had a 98.27 to 98.88% fit. Finally, the drying shrinkage, with mixes of 12% cement and water content variations with water-reducing admixture and superplasticizer effects, had an adjustment of 94.87%.
Harnessing a Dielectric/Plasma Photonic Crystal as an Optical Microwave Filter: Role of Defect Layers and External Magnetic Fields
Authors: Dakhlaoui Hassen , Belhadj Walid , Elabidi Haykel , Al-Shameri Najla S. , Ungan Fatih , Wong Bryan M.
Published: January 2024

We investigate the transmittance spectrum of a multichannel filter composed of dielectric (A) and plasma (P) materials in the microwave region within the transfer matrix formalism. Two configurations of the proposed filter are studied under the influence of an applied magnetic field: (1) a periodic structure containing (A/P)N unit cells surrounded by air and (2) the introduction of a second dielectric material (D) acting as a defect layer to produce an (AP)N/2/D/(AP)N/2 structure. Our findings reveal that in the periodic case, the number of resonant states of the transmittance increases with number N; however, the observed blue and red shifts depend on the intensity and orientation of the applied magnetic field. We present contour plots of the transmission coefficients that show the effect of the incident angle on the shifts of the photonic band gaps. Furthermore, we find that the introduction of a defect layer generates additional resonant states and merges the central resonant peak into a miniband of resonances. Moreover, we show that the number of resonant peaks and their locations can be modulated by increasing the unit cell number, N, as well as increasing the width of the inserted defect layer. Our proposed structures enable the design of novel photonic filters using magnetized plasma materials operating in the microwave region.