bluuebunny/crossref_metadata_2025 huggingface dataset:
Uric acid as a predictor of adverse treatment outcomes in women undergoing in vitro fertilization
Authors: Yan Niwei , Song Junli , Jie Huiying , Lee Pingyin , Liu Simin , Yuan Yuan
Published: May 2023

Introduction Current knowledge on the association of uric acid (UA) as a scavenger of free radicals with the reproductive outcomes of in vitro fertilization is largely limited, since most of the available data are focused on pregnancy complications, and high UA concentration was proposed as a risk indicator for adverse maternal and even infant risks. In the reproductive system, several studies have revealed that UA is involved in female reproductive diseases and that UA accumulation may cause reproductive disorders. However, the effect of UA on the progression of the evolution and quality of oocytes or embryos remains unexplored and unknown. This study aimed to explore the relationship between serum uric acid and reproductive outcomes in women undergoing in vitro fertilization procedures.
Methods 1027 women without any intervention on serum UA levels who underwent the COH procedure and treatment with PGT-M and PGT-A were included, leaving a total of 1,177 samples available for analysis. Finally, 1,177 subjects were further divided into 3 groups according to the serum UA levels: the ≤250 μmol/L group (N=347), the 251-360 μmol/L group (N=669), and the >360 μmol/L group (N=161).
Results The number of retrieved oocytes, mature oocyte rate and good-quality blastocyst rate were individually negatively related to hyperuricemia.
Conclusions The presence of high serum uric acid could lead to a change in the follicular microenvironment, insufficient ovarian blood supply and overexposure of ovarian follicles and embryos to hypoxia and inflammation responses, which strengthened the utility of uric acid as a promising biomarker in clinical practice, particularly in in vitro fertilization procedures, that could contribute to early detection, decision-making about intervention, and improvement of reproductive treatment outcomes.
Fertility-related Quality-of-Life in men undergoing Medically Assisted Reproduction during the pandemic: Sexual beliefs moderate the effects of sexual functioning
Authors: Vallone Francesco , Pugi Daniele , Dèttore Davide , Cuomo Alessandro , Fagiolini Andrea , Coccia Maria Elisabetta , Pozza Andrea
Published: May 2023

Background . Following a diagnosis of infertility, an increasing number of couples are turning to Medically Assisted Reproduction (MAR) to achieve a pregnancy, which can have a detrimental impact on the individual's Quality-of-Life, leading to heightened risks of anxious-depressive symptoms and stress. Little is known about men’s infertility-related Quality-of-Life, and among the variables potentially associated with it, the role of sexual beliefs is neglected.Methods . This study included 166 participants, with 83 men attending a MAR pathway, while a control group of 83 subjects, paired by age, marital status, and number of children was drawn from the general population. Sexual-Modes Questionnaire, Depression-Anxiety-Stress-Scale, Arizona Sexual Experience Scale, and Fertility Quality-of-Life Questionnaire were administered.Results . Among men undergoing MAR, higher levels of erection-related thoughts were associated with a worse Quality-of-Life, but when they occur alongside sexual dysfunction, they were linked to a better Quality-of-Life. Negative thoughts about sex were associated with a higher Quality-of-Life, but when combined with sexual dysfunction, they were associated with a worse Quality-of-Life.Conclusions . Overall, the study highlights the negative impact of certain sexual beliefs on the Quality-of-Life of men undergoing MAR and suggest that psychological interventions should be tailored to the beliefs with which men approach the infertility treatment.Trial Registration. The study was approved on October 27, 2020, by the Institutional Ethics Committee of the Careggi University Hospital of Florence, Italy (approval code: 18326_OSS). Participants provided written informed consent.
Bayesian optimization genetic algorithm based on automated stereo warehouse space optimization
Authors: Chen Jinpeng , Kang Shaobo , Cao Li
Published: May 2023

Automated three-dimensional warehouse is one of the important development directions of modern logistics industry, which can achieve efficient, accurate and safe logistics operation and improve the competitiveness of logistics enterprises. In order to fully exploit the advantages of automated three-dimensional warehouses, the storage of goods in automated three-dimensional warehouses must be reasonably designed and optimized to improve space utilization and logistics efficiency. In this paper, a hybrid algorithm based on a combination of Bayesian optimization algorithm and genetic algorithm is proposed to solve the problem of cargo space layout and cargo storage strategy in an automated three-dimensional warehouse. The method uses the Bayesian optimization algorithm to adaptively adjust the parameters of the genetic algorithm to improve the search capability and convergence speed of the genetic algorithm, while preventing the genetic algorithm from falling into local optimum solutions. Through experimental and simulation analysis, this paper demonstrates the effectiveness of the method in improving the cargo space utilization rate and warehouse operation efficiency, and outperforms the method using genetic algorithm alone in terms of performance and stability, providing a new way of thinking and method for the design and management of automated three-dimensional warehouses, with certain theoretical significance and practical value.
Study of the mechanical behavior of swelling and highly compacted clays in road construction
Authors: Ouslimane Noureddine , Bensalah Jaouad , Barebita Hanane , Belfaquir Mustapha
Published: May 2023

Clays considered “problematic” swelling clay soils in the construction of road infrastructures. They generally associated with high compression, high plasticity, and evolutionary behavior. The objective of this article is to study the mechanical behavior of swelling clays and particularly a clay from the Kenitra region. To do this, samples taken from the main clay sites in the region. They then subjected to several series of tests in the laboratory, namely identification tests and mechanical tests (shear test and odometer compressibility test). The results obtained show that the clays studied exhibit very different behaviors. Indeed, the clays of Sidi Slimane, Sidi Kacem and Ouazzane have very interesting mechanical characteristics and can offered in their natural state as road materials, at least for pavements. Ouazzane clay, on the other hand, has very swelling mechanical characteristics (Cg = 0.06), and clay from Sidi Slimane (Cg = 0.04) and Sidi Kacem (Cg = 0.05) and cannot be used in its raw state. Natural without any treatment.
Suwonella silvatica gen. nov., sp. nov., a new genus of family Neisseriaceae isolated from forest soil in Suwon, South Korea by a soil substrate membrane system
Authors: Trinh Ngoc Hoang , Kim Jaisoo
Published: May 2023

A novel Gram-stain-negative, aerobic, non-motile and rod-shaped bacterial strain designated JH1-16T, was isolated from a forest soil sample in Suwon, Republic of Korea by using a soil substrate membrane system. The strain grew well on Luria-Bertani agar, Mueller-Hinton agar, nutrient agar, R2A agar and tryptic soy broth agar. Strain JH1-16T could grow at temperature of 10–35 °C (optimum, 25–28 °C on R2A, MHA and TSB agar), tolerated pH 9.0 and 2.5% (w/v) NaCl. Phylogenetic analysis based on the sequences of 16S rRNA gene and whole genome indicated that JH1-16T made a distinct cluster with members of the family Neisseriaceae. Strain JH1-16T showed the highest 16S rRNA sequence similarity to Vogesella oryzae L3B39T (93.3%), Crenobacter cavernae K1W11S-7T (93.2%), Vogesella amnigena Npb-02T (93.2%), Crenobacter luteus YIM 78141T (92.9%). The major polar lipid profile comprised phosphatidylglycerol, diphosphatidylglycerol, phosphatidylethanolamine, two unidentified aminolipids, and an unidentified phospholipid. The major respiratory quinone system was ubiquinone Q-8. The main fatty acids were C12:0, C16:0, C12:0-3OH, and summed feature 3. The DNA G + C content of the isolated strain was 63.8 mol% calculated by the whole genome sequence. The average nucleotide identity and digital DNA–DNA hybridization between strain JH1-16T and its reference type strains were below the species threshold values. Based on evidences of polyphasic approach, strain JH1-16T (= KACC 21685T = JCM 35861T) could be proposed as the type strain of a new genus and species in the family Neisseriaceae, for which the name Suwonella silvatica gen. nov. is proposed.
Reliability of a Novel Method to Assess Acute Bacterial Conjunctivitis by Photographs With a Smartphone: A More Reliable Patient-Centred Care
Authors: Figus Michele , Rossetti Luca Mario , Posarelli Chiara , Romano Dario , Castellino Niccolò , Carnovali Marino , Ciprandi Giorgio , Avitabile Teresio
Published: May 2023

Purpose Acute bacteria conjunctivitis (ABC) is a common disease. As ABC diagnosis is usually based on clinical criteria, the present study aimed at investigating the reliability of photographs performed thorough smart phone.Methods This study was an observational, prospective, inter-method reliability study conducted in three sites in Italy. The patients with ABC enrolled in the study underwent two visits. The signs’ assessment was performed by the Investigators and compared with assessment of photographs’ scores.Results Twenty ABC patients completed the study. Considering the three cardinal signs separately, all the ICCs revealed excellent concordance, being the point estimates ranging between 0.92 and 0.96 and the corresponding 95% CIs totally above 0.75 (i.e., the cut-off of excellent agreement.Conclusions The photographic method's inter-method reliabilities, sensitivity, and specificity were excellent. Therefore, the photographic evaluation of patients suffering from acute bacterial conjunctivitis can allow an accurate follow-up of the evolution of the pathology, which needs to be carried out in clinical practice due to the difficulty of re-evaluating the patient in a clinical setting within a short timeframe. Furthermore, the photographic method could also be usefully employed in clinical trials requiring continuous patient monitoring to compare the speed at which different therapeutic approaches achieve control of disease signs.
Computational Intelligence-Based Classification System for The Diagnosis of Memory Impairment in Psychoactive Substance Users
Authors: Zhu Chaoyang
Published: May 2023

Computational intelligence techniques have emerged as a promising approach to the diagnosis of various medical conditions, including memory impairment. The increasing abuse of psychoactive drugs presents a global public health burden, as repeated exposure to these substances can cause neurodegeneration, premature aging, and negatively affect memory impairment. Although the basis for these neurotoxic effects has not been fully elucidated, compelling evidence has shown that dysregulation of neurotransmission, disruption of mitochondrial function and dynamics, impairment of neuroimmunomodulation, and epigenetic changes result from many psychoactive substances. (eg, alcohol, cannabis, opiates, amphetamines and cocaine). Computational intelligence used in this study to classify the brain image from MRI or CT scan and show the effective of dose ratio on the health with time of treatment, diagnosis of memory impairment in psychoactive substance users. Understanding the neurotoxic profiles of psychoactive substances and the underlying pathways is assumed to be of great importance towards improved risk assessment and treatment of substance use disorders. As such, we found the brain diagram and its effect on drug-induced cellular and molecular mechanisms. thus we conclude that good classification in such field may save human life or early detection of memory impairment via classification of brain cells and tissues.
The impact of agriculture production and renewable energy consumption on CO2 emissions in African countries: The Role of Governance
Authors: Dauda Lamini , Xingle Long , Mensah Claudia Nyarko , Ampon-Wireko Sabina
Published: May 2023

Environmental pollution has aggravated the Climate change issues posing unusual challenges to the survival and growth of humanity, including extreme weather, loss of species, and sustainability of the ecosystem in developing countries. The study therefore examines the effects of governance (corruption) and agriculture production on CO 2 emissions in 20 countries in Africa from 1990 to 2019. Unlike previous studies this paper incorporates corruption into agriculture production-environment nexus. The study employed recent panel econometric approach which accounts for cross section dependence in the variables. The findings of the fixed effect model and panel dynamic ordinary least square (PDOLS) show that forest and renewable energy consumption decrease CO2 emissions. However, corruption, agriculture production, export, and urbanization escalate CO2 emissions in African countries covered in the paper. Moreover, the Dumitrescu-Hurlin granger causality indicates a bidirectional causality between agriculture production and CO2 emissions, renewable energy use, agricultural output and forest. Also, unidirectional granger causality runs from corruption to forest and agriculture production. On these premise, consented effort by governments should be made to support good institutions in order to promote good governance to avert pervasive consequences of corruption on the environment.
Flow Around Tandem Cylinders and Dynamic Meshing
Authors: Singh Prabhjot , Klein Marten
Published: May 2023

The behavior of flow around a single cylinder is complex, and when multiple cylinders are arranged in a tandem or multi-cylinder configuration, the complexity increases significantly. This arrangement is commonly used in aerodynamic applications and dynamic states, presenting challenges in grid and mesh quality, boundary conditions, numerical stability, and mesh adaptivity. This study aims to simulate flow around multiple cylinder arrangements, comparing static and dynamic cases and presenting results through vorticity distributions, wake flow, pressure distributions, drag and lift coefficients, and flow separations. The paper addresses the strategies used for numerical setup, boundary conditions, solvers, or models used using OpenFOAM open-source code, and data validation. In addition, the study simulates the flow around rotating multiple cylinders using dynamic meshes, ensuring good transport of properties between the boundaries of the dynamic mesh while retaining the underlying physics. The results show that the flow around the cylinder is laminar and steady for Reynolds numbers below approximately 40-50, while Von Karman vortices can be observed for Reynolds numbers between approximately 40-200, and horseshoe vortex for Reynolds numbers greater than approximately 200. The Coefficient of pressure also changes accordingly. With dynamic arrangement, the study was able to establish a good master-slave arrangement, depict complex mean flow between the cylinder, and periodic changes in Coefficient of pressure along the rotating cylinder. Result validation was also conducted. This dynamic mesh and simulation for rotating cylinders are still a work in progress, with ongoing efforts to develop a solver for greater accuracy and less computational expense and time-consuming simulations. Future expectations include the concept of vertical axis turbines and other commonly used in aerodynamic applications.
Guiding the Honeybee Navigation System Using the Second-Harmonic Line Width of 456 nm Nd:GdVO4 Laser to Prevent CCD Phenomenon
Authors: Mohammadi Fatemeh , Bozorgmanesh Mohammad Amin
Published: May 2023

Today, one of the biological problems is electromagnetic pollution in the environment. The intensity of electromagnetic radiation is so pervasive that it is now known as a form of latent and silent pollution. The study of the biological effects of these waves on the growth and development of living insects - such as bees - are considered by many scientific communities around the world. However, the response of honey/wild bees to traps designed to selectively stimulate bee light receptors by fluorescent light indicated that selective arousal of the blue light receptor type was highly attractive. In this paper, to selectively stimulate the blue light receiver in bee species in order to guide the bee navigation system to return to its hive and prevent the colony collapse disorder (CCD) phenomenon, high-efficiency continuous laser emission by second-harmonic line width of 456 nm Nd:GdVO4 laser is proposed.
Compost and biogas market in Côte d'Ivoire: Economic impact assessment by CGE model
Authors: Fabrice Ochou Essé , Kamagaté Tidiane , Dagbaud Ulrich , koné Tiangoua
Published: May 2023

The latest National Determined Contributions in Côte d'Ivoire reveal that the waste sector is a significant contributor to greenhouse gas emissions. Despite the potential for composting and biogas to increase waste valorization, these sectors are underdeveloped and lack a legal framework. The aim of this paper is to analyze the economic benefits of a composting and biogas policy implementation in Côte d'Ivoire. Using a Computable General Equilibrium Model (CGE), the study takes into account the impact of these sectors on the economy and the effects of household and agricultural wastes, which are currently excluded from the national nomenclature. The results of the simulation showed positive impacts on green growth, employment, investment and demand, among others.
Outcomes of Intervention Program on Nurses Caring of Patients with Heart Failure
Authors: Elsenousy Tahany Ahmed , Maarouf Dina Mohamed , Mohamed Mahmoud Hassan
Published: May 2023

Heart failure (HF) is a chronic condition that affects a significant number of patients worldwide, requiring specialized management. Nurses have a great role in the care of these patients, and intervention programs are designed to enhance their performance, leading to improved patient outcomes.
Objectives: To investigate the outcomes of the HF intervention program regarding nurses' knowledge, practice, and patient outcomes at the Cardiac Care Unit (CCU).
Method: A quasi-experimental research design was implemented in this study. The study included all 30 cardiac nurses working on the unit. In addition, a convenience sample of 108 conscious adults with HF was divided into two groups of 54 patients each. For collecting data, four different tools were used. Tool I: A Structured Knowledge Questionnaire; Tool II: Heart Failure Management Observational Checklist; Tool III: Patients' Assessment Questionnaire; and Tool IV: Kansas City Cardiomyopathy Questionnaire (KCCQ-12).
The study results showed significant differences in the knowledge and practice categories of nurses following the intervention program compared to their pre-intervention levels. After the intervention program, the nurses displayed good knowledge and satisfactory practice, compared to poor knowledge and unsatisfactory practice before the program (p = 0.00). Furthermore, the study group displayed a significant improvement in their KCCQ-12 total mean score (42.4 ± 16.6) compared to the control group (38.5 ± 17.7) (p = 0.00).
In conclusion, this study provides strong evidence of the HF intervention program's effectiveness in enhancing nurses' knowledge and practice, as well as improving patient outcomes.
Is rhythmic auditory stimulation the most effective therapy for functional ambulation after stroke? A systematic review
Authors: Gonzalez-Hoelling Samira , Reig-García Gloria , Bertran-Noguer Carme , Suñer-Soler Rosa
Published: May 2023

Background
Several studies have reported the effect of rhythmic auditory stimulation (RAS) on functional ambulation in stroke patients, yet a systematic overview is currently lacking. This study aims to summarize and evaluate the available evidence about the efficacy of RAS for functional ambulation, consider the use of walking assistive devices during the assessment or the intervention in stroke patients, and to find out if the effect of RAS and music-based RAS differs depending on the stroke brain site and affected area.
Methods
The Pubmed, PEDro, Cochrane Central Register of Controlled Trials, Web of Science, Scopus and CINAHL electronic databases were searched for reports evaluating the effect of RAS on walking in stroke patients.
Results
Nineteen articles were included (916 stroke survivors). Most studies were of good methodological quality according to the PEDro scale, but they had a high risk of bias. The most consistent finding was that RAS improves walking and balance parameters in stroke patients in all phases compared to baseline and versus control groups with conventional treatment. Functional ambulation and the use of walking assistive devices were inconsistently reported. Several studies also suggest that RAS may are as good as other complementary therapies (horse-riding and visual cueing).
Conclusions
Despite the beneficial effects of RAS, the question remains as to whether it is better than other complementary therapies. Given the heterogeneity of the interventions, the interventions in control groups, the varied durations, and the different outcome measures, we suggest that care should be taken in interpreting and generalizing findings.
PROSPERO registration number
: CRD42021277940
Response of Common Wildflower Species to Postemergence Herbicides
Authors: Henry Gerald , Tucker Kevin , McCurdy Jay
Published: May 2023

Wildflowers attract wildlife, increase pollinator habitat, and enhance the aesthetic value of the landscape. Wildflower establishment is increasingly part of an effort to reduce maintained turfgrass on golf courses, lawns, and other maintained environments. Weed competition decreases wildflower establishment and results in poor long-term stands. Research was conducted in a controlled environment to investigate the tolerance of wildflower species to common postemergence herbicides. Wildflower species included California poppy (Eschscholzia californica Cham.), common sunflower (Helianthus annuus L.), cornflower (Centaurea cyanus L.), garden coreopsis (Coreopsis lanceolata L.), partridge pea [Chamaecrista fasciculata (Michx.) Greene], plains coreopsis (Coreopsis tinctoria Nutt.), purple coneflower [Echinacea purpurea (L.) Moench], rosering gaillardia (Gaillardia pulchella Foug.), and violet prairie clover (Dalea purpurea Vent.). Herbicides evaluated were fluazifop at 0.28 kg⋅ha–1 a.i., mesotrione at 0.14 kg⋅ha–1 a.i., clopyralid at 0.29 kg⋅ha–1 a.i., bentazon at 0.56 kg⋅ha–1 a.i., halosulfuron at 0.053 kg⋅ha–1 a.i., and imazaquin at 0.42 kg⋅ha–1 a.i. An untreated check was included for comparison. Excessive damage (≥ 53% phytotoxicity) was observed on all wildflower species in response to clopyralid, except for California poppy. Fluazifop and bentazon were relatively safe (≤ 19% phytotoxicity, regardless of herbicide) on all wildflower species; however, bentazon resulted in ≥ 40% aboveground biomass reduction in several species. Common sunflower and garden coreopsis were susceptible to halosulfuron (37% and 73% phytotoxicity, respectively) and imazaquin (37% and 87% phytotoxicity, respectively), but on all other wildflower species, phytotoxicity was ≤ 18%. Although both halosulfuron and imazaquin only resulted in ≤ 18% phytotoxicity to purple coneflower, a 43% to 44% aboveground biomass reduction was recorded. Mesotrione was only safe on California poppy and cornflower (≤ 11% phytotoxicity and ≤ 24% aboveground biomass reduction). Results suggest high tolerance variability across herbicides and species considered, but may prompt new investigation of safety and utility within field and production scenarios.
Re-examination of centre of buoyancy curve and its evolute for rectangular cross section, Part 2: Using quadratic functions
Authors:   University of Split Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, 21000 Split, Ban Dario ,   Croatia
Published: May 2023

In this paper, exact hydrostatic particulars equations for the centre of buoyancy curve and metacentric locus curve are given for rectangular cross section using quadratic functions. Those equations have not been given for the hyperbola range of the heel angles so far, and here it is done by using basic quadratic functions and their horizontally symmetric immersion shapes, with two new methods defined: 1. Rotation of basic cross section shapes, and 2. Hydrostatic cross section area complement method that uses homothety or scaling properties of emerged and immersed areas of the rectangular cross section. Observed metacentric curve for rectangle consists of semi-cubic parabolas and Lamé curve with 2/3 exponent and negative sign, resulting in the cusp discontinuities in the symmetry of those functions definition. In order to achieve above, two theorems are given: the theorem about scaling using hydrostatic cross section area complement and the theorem about parallelism of centre of buoyancy tangents with waterlines. After non-dimensional bounds are given for the existence of the swallowtail discontinuity of metacentric curve for rectangular cross section in the Part 1 of this paper, the proof of its position in the symmetry of rectangle vertex angle is given in this Part 2 of the paper, thus confirming its position from theory.
ACUTE FATTY LIVER OF PREGNANCY: CLINICAL FEATURES AND TREATMENT STRATEGIES IN A SINGLE-CENTER STUDY
Authors:   Department of Gynecology-Obstetrics, Mohammed IV University Hospital., Ousti A. , Lamzouri O. ,   Department of Gynecology-Obstetrics, Mohammed IV University Hospital., Taheri H. ,   Department of Gynecology-Obstetrics, Mohammed IV University Hospital., Saadi H. ,   Department of Gynecology-Obstetrics, Mohammed IV University Hospital., Mimouni A. ,   Department of Gynecology-Obstetrics, Mohammed IV University Hospital.
Published: May 2023

Acute Fatty Liver of Pregnancy (AFLP) is a rare but life-threatening complication of pregnancy that typically occurs in the third trimester. This study aimed to investigate the clinical and demographic features of patients with AFLP and evaluate the effectiveness of various treatment strategies. A total of five patients were diagnosed with AFLP between January 2020 and December 2022. The mean age of the patients was 28 years, with two patients having a history of diabetes, and two patients were COVID-19 positive. The mean gestational age at diagnosis was 31 weeks and 1 day, with two patients admitted for high blood pressure, one for sudden onset jaundice, and two for delivery. All patients met the Swansea criteria for AFLP diagnosis. Three patients developed neurological symptoms in the postpartum period, two with hypoglycemic coma due to liver failure and one with hepatic encephalopathy. Two patients had renal insufficiency, one with a hemorrhagic syndrome, and one with disseminated intravascular coagulation (DIC). All patients had thrombocytopenia, and two patients had a platelet count below 50,000. Obstetric ultrasound/doppler showed an evolving monofetal pregnancy in four cases and fetal demise in one case. Two patients were treated with therapeutic plasma exchange, and two underwent continuous renal replacement therapy until renal function normalized. The patient with a hemorrhagic syndrome received two units of platelets postpartum, while the patient with DIC received fresh frozen plasma. One patient had a vaginal delivery, while four patients had a cesarean section.
REVIEW ON ADVANCEMENT OF BIOFILM BIOFERTILIZER AND ITS IMPACT ON STRESS RESISTANT PLANTS
Authors:   Departmentof Microbiology, Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F, Nilgunj Rd, Sahid Colony, Panihati, Kolkata, West Bengal 700114, India., Roy Orpa , Chakraborty Tamalika ,   Departmentof Microbiology, Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F, Nilgunj Rd, Sahid Colony, Panihati, Kolkata, West Bengal 700114, India.
Published: May 2023

Nutrients from plants are essential for the cultivation of crops and the production of healthy food to feed the worlds growing population. The impacts of global warming threaten nearly every economic sector, including agriculture. In order to maintain ecological equilibrium, microorganisms play an important role in the natural carbon, nitrogen, sulphur, and phosphorus cycles. Microbial biofilms are an intriguing issue because of their implications for ecology, economy, and human health. Advances in biochemical and molecular approaches have helped us gain a better grasp on how biofilms form and evolve. Growers are starting to take notice of biofilms because of their vast potential in agricultural productivity, security, and enhancement. Biofilms not only increase plant productivity, but they also play a critical role in the colonization of surfaces including soil, plant roots, and plant shoots. Utilizing bio-fertilizers allows plants to better absorb nutrients, thrive, and resist environmental stresses such as drought and pests. Potential biological fertilizers would be essential to the productivity and sustainability of soil, as well as to environmental conservation, because they are both environmentally beneficial and economical inputs for farmers.
HOW EFFECTIVE IS STEENBEEKS BRACE IN MAINTAINING CORRECTION IN CLUBFOOT AFTER PONSETI TREATMENT
Authors: Vidyarthi Ashok , Raza S.M.G. , Kumar Tripathi Jitendra
Published: May 2023

Background: The term clubfoot refers to a variety of related congenital foot deformities. It is used interchangeably to refer to clubfoot deformities that are idiopathic, atypical, syndrome, and postural. Scales designed specifically for clubfoot, like the Pirani and Dimeglio Scales, are frequently used to categorize severity. Therefore, this study is aimed to evaluate the effectiveness of Steenbeek Foot abduction brace (SFAB) to maintain the correction achieved. Methodology: A Cross-sectional study conducted at CTEV Clinic, Department of Orthopaedic, NSCB Medical College, Jabalpur from the period of 1st Jan 2021 to 31st June 2022 with a sample size of 50 estimated through n = z2pq / d2. Study participants include Child age- <=1.5 years and Unilateral / Bilateral Idiopathic Club Foot. Statistical analysis was done through IBM Software SPSS 21.0 and association was found with confidence Interval of 95% and p-value<0.05. Results: Current study concluded that maximum are males (54%) with an age-group of <6 months (64%) presented Bilateral CTEV (60%). Furthermore, treatment effectiveness was highest in number with the significant association between treatment effective and sex (p-value<0.05). Meanwhile, relapse was found in females comparatively to males with no statistically association (p-value>0.05). Conclusion: The desired goal of achieving minimal disability as a result of clubfoot can be assisted in its achievement by enhancing the education and counselling of parents, removing social barriers, strengthening the training of health providers, improving access to affordable braces, and eliminating social barriers.
A STUDY OF INFLUENCE OF MENOPAUSE ON SERUM LIPID PROFILE
Authors:   Assistant Professor, Department of Physiology, Govt. Sivagangai Medical College, Sivagangai., A. Sivapriya , K.A Malarvannan ,   Associate Professor, Department of Surgery, Govt. Ramanathapuram Medical College, Ramanathapuram.
Published: May 2023

Background: Menopause is a physiological change due to which women passes from fertile to infertile period. Decreased oestrogen production in post menopausal women alter the lipid metabolism. Since altered serum lipid profile seen in menopause is one of the significant risk factors for developing coronary heart diseases, influence of menopause on lipid levels is aimed to study. Aim and Objective: To study the influence of menopause on serum lipid profile by estimating the level of serum cholesterol and various lipoproteins in premenopausal and post menopausal women. Methods: After getting ethical committee approval, in this cross sectional study, women of age 45- 55 and normal BMI attending Government Sivagangai Medical College for master health checkup were selected. Informed consent obtained and estimation of serum lipid profile was done for all of them. Results: Statistical analysis was done by students t test and the results were compared between pre and post menopausal women. In post menopausal women, the mean values of triglycerides (p=0.016) and very low density lipoprotein levels (p=0.046) were increased significantly. Conclusion: Significant increase in serum triglycerides and very low density lipoproteins is due to menopause which causes changes in body metabolism. Serum lipid levels should be checked periodically after menopause and life style modifications should be adviced at an earlier stage.
STUDY OF SERUM URIC ACID LEVELS IN CIRRHOSIS OF LIVER AND ITS CORRELATION WITH CHILD PUGH SCORE
Authors:   Junior Resident, MD General Medicine., Pradnya Ashokrao Kotule , U. Jadhao Ganesh ,   Associate Proffessor, MD General Medicine., S. Yelke Baba ,   Professor and HOD, MD General Medicine.
Published: May 2023

Background: Liver cirrhosis is one of the most common causes of morbidity and mortality. Elevated serum uric acid (UA) levelsstrongly reflect progression of liver disease. Child Pugh Scoreused to assess the severity of cirrhosis of liver. The present study was undertaken toestimate the level of serum UA in liver cirrhosis patients and its association with the child Pugh score. Method: A total 70 patients diagnosed with cirrhosis of liver, aged above 20 years were included in the study. For each patient, a modified Child Pugh Score were calculated. Blood samples were collected, and hematological and biochemical tests were performed. Results: The mean serum UA level was 7.53mg/dl, and it was raised in patients with liver cirrhosis disease in relation to its severity. Alcoholic liver disease was the most common etiology for liver cirrhosis (80%). The mean serum AST and ALT level was 72.8mg/dland42.07mg/dlrespectively, theywere not increasing with increase in serum UA level. Whereas mean serum total bilirubin level and INR value was 2.73mg/dl and 2.02mg/dl respectively, they increasedwith increase in serum UA level. The mean serum albumin level was 2.6mg/dl and it decreased withincrease in serum UA level. Serum UA levels increased as CTP score increased. Maximum UA levels were found in CTP class C (Mean 9.23mg/dl) and maximum mean UA levels (6.6mg/dl) were noted in alcoholic liver disease. Conclusions: Serum UA level is an important part of spectrum of liver cirrhosis disease.UA is a mediator of inflammation and tissue damage thus, itmay be considered as a marker of severity of liver cirrhosis disease.
PREVALANCE OF HELICOBACTER PYLORI INFECTION IN DYSPEPTIC PATIENTS UNDERGOING UPPER GI ENDOSCOPY IN TERTIARY HOSPITAL
Authors:   General Surgery Resident., Bhaskar A. , Bandi Issac ,   House Surgeon/ Intern., a Gowtham ,   General Surgery Resident., Channanna Dr. ,   Professor and Head Of The Department Of General Surgery, Pesimsr, Kuppam.
Published: May 2023

Background And Objectives:-Acid peptic disease comprises of a wide spectrum of diseases, which cause considerable morbidity. Helicobacter pylori, a curved rod-shaped bacterium, has been consistently associated with patients suffering from acid peptic diseases, more in ulcer disease than in non-ulcer disease. Due to this high association, it is now believed that helicobacter pylori plays an important role in the aetiopathogenesis of acid peptic disease. Methods:We Have Attempted To Study The Prevalence Of H.Pylori In Patients Undergoing Upper GI Endoscopy In Patients With Dyspepsia At Our Pes Hopital(Pesimsr) ,Kuppam,AndhraPradesh. Results:-Total Of 100 Upper Gastro Intestinal Endoscopies Were Performed And Biopsies Were Taken During The Study Period In Which Males Were More Infected With H.Pylori Infection In The Age Group Of 31-50 Years . Conclusion:-The Burden Of H.Pylori Infection Among Dyspeptic Patients Was High.There Is Limited Access To Endoscopic Services And Widespread Prior Antibiotics as Empirical Treatment.
CLINICAL SPECTRUM ANDETIOLOGY OF CHILDHOOD STATUS EPILEPTICUS IN A TEACHING HOSPITAL, KASHMIR, INDIA
Authors:   Post Graduate 3rd Year Resident, Department of Pediatrics Government Medical College Srinagar Kashmir India., Muzamil Mehraj Syed , Ahmad Tak Shafat ,   Professor, Department of Pediatrics Government Medical College Srinagar Kashmir India., Ahmad Naik Suhail ,   Department of Pediatrics Government Medical College Srinagar Kashmir India.
Published: May 2023

Objective: The study aimed to ascertain clinicalspectrum and different etiologies of convulsive status epilepticus in children. Methods: Hospital based prospective observational study performed in department of Pediatrics in Children Hospital Government Medical College Srinagar Kashmir India from October 2020 to September 2022.Data were recorded with the help of a pre-formed proforma. Results: In this study, 184 cases of status epilepticus were included. The infants (less than 1-year)accountfor 23.9% ofthetotalcases(n=184) and67.4% children were in the age group < 5 years. The total number of cases in the age group >10yrs was only 6.5%.Outof184children,malechildrenwere102(55.4%)andfemalechildrenwere82(44.6%).We found that 81.5%ofthecases of CSE reachedEmergency Room (ER)within30-60minutes after seizure initiation and18.5%reachedafter 60 minutes. Themostcommonetiologyassociatedwithstatusepilepticuswasremotecauses like post HIE or cerebral palsy, seen in 25.54% cases, followed by acute CNS infection in 18.45 cases (pyogenic meningitis 10.3%, viral encephalitis 4.9%, and tubercular meningitis 3.26%). Conclusion: The outcome was better for patients who had less seizure duration and received early effective standard treatment protocol within a given time frame. The patients who had prolonged seizures or first treatment hadapoor outcome. Our study reveals that though we have successfully decreased the infant mortality rate, still there is large scope for decreasing morbidity by improving the neonatal care services across Kashmir and the intact Neonate intact Nation should be our mission and passion. Furthermore, it seems very imperative that all patients of CSE should receive early effective standard treatment at doorsteps to decrease the associated morbidity and mortality.
Effect of almond (Prunus dulcis) hull addition to corn silage on silage quality, silage fermentation properties and in vitro digestibility
Authors: S.S. AYDIN
Published: May 2023

This study aimed to determine the effects of the addition of almond hull to corn silage on silage quality, fermentation properties and in vitro organic matter digestion (IVOMD). While corn silage without additives constituted the control group in the study, silages with almond hull added at the levels of 0.5%, 1%, 1.5%, 2% and 2.5% formed the experimental groups.The addition of almond hull caused an increase in the IVOMD and metabolizable energy (ME) values of the silages compared to the control group. For all the experimental groups, the methane (CH4) values of the silages were lower than the values of the control group. The silage pH range of all silage groups was in the range of 3.62-3.70. The lactic acid (LA) and acetic acid (AA) values of the silages, on the other hand, were higher in all experimental groups compared with the values of the control group, and the highest values were observed in the group with the 1% almond hull addition. No propionic acid (PA), butyric acid (BA), or mold was detected in any of the silage groups. The yeast values, on the other hand, were lower in all silages that contained added almond hulls than the in the control group. The amount of CO2 produced in the silage groups decreased in parallel with the increase in almond hull. This study will enable more use and evaluation of almond hulls in animal nutrition due to its positive effect on fermentation.
Removal of antibiotics with different charges in water by graphene oxide membranes
Authors: Liang Zimeng , Zhao Xin , Huang Weiqi , Qi Huabiao , Wang Can
Published: May 2023

Antibiotics are a large group of emerging organic pollutants with low concentration levels in the water. The presence of antibiotics will affect the ecological environment and human health. The removal of trace organic compounds by graphene oxide (GO) membranes has attracted extensive attention. This study investigated the removal of three differently charged antibiotics by GO membranes and the influence of water quality on the removal of antibiotics. It showed that a crosslinked ethylenediamine-GO (EDA-GO) membrane had better stability and higher antibiotic removal performance than a non-crosslinked GO membrane. Among the three antibiotics, penicillin (PNC) was negatively charged and had the highest removal efficiency due to steric effect and electrostatic repulsion. A low concentration (10 mmol L−1) of Na+ in water could increase the membrane flux but had no significant effect on the removal of antibiotics. Ca2+ could reduce the membrane flux and improve the removal of chloramphenicol (CAP) and PNC. The removal efficiencies of low-concentration antibiotics (500 μg L−1) were higher than those of high-concentration antibiotics (10 mg L−1). Furthermore, the removal of antibiotics under the condition of actual wastewater quality was higher than those in solutions prepared with ultrapure water. The EDA-GO membrane has great potential in the removal of antibiotics in wastewater.
Catatumbo: análisis de los factores socioeconómicos y su relación con la productividad de la región
Authors: Peñaranda-Peñaranda Leidy Paola , Hernández-Urbano Greys Keren , Mogrovejo-andrade Johanna Milena , Bastos-Osorio Liliana Marcela , Mera-Ramírez Oscar Arnulfo
Published: May 2023

Este artículo analiza los factores socioeconómicos y su relación con la productividad en la región del Catatumbo, zona golpeada históricamente por diferentes agentes del conflicto armado, quienes destinaron el territorio para el cultivo ilícito de estupefacientes y el contrabando. Esta investigación presenta el panorama socioeconómico de la región y da a conocer nuevas oportunidades económicas y sociales en pro de la región. Adicionalmente, esta investigación se desarrolla mediante una metodología de tipo cualitativa con método inductivo y tipo de estudio descriptivo, cuyo objeto es especificar las variables: índice de necesidades básicas insatisfechas, ordenamiento territorial, conflicto armado, economía, finanzas públicas, salud, vivienda, servicios públicos, educación, medio ambiente, medición de desempeño municipal, demografía y población. Para finalizar, se concluye que la región del Catatumbo es altamente rica en recursos naturales, lo que ofrece la oportunidad nacional e internacional de comercializar su producción agrícola; sin embargo, esta oportunidad es desaprovechada debido al desconocimiento de los agricultores o las asociaciones productivas del Catatumbo sobre el potencial productivo de la región.
Socioeconomic determinants of economic reintegration in Colombia: evidence from a Probit Model
Authors: Luna-Amador Jorge Armando , Escobar-Espinosa Álvaro Andrés , Caraballo-Payares Alexander Mauricio , Padilla-Castilla Amalfi
Published: May 2023

This paper seeks to determine what socioeconomic aspects influence the economic reintegration process of former combatants from illegal armed groups in Bolívar, Colombia. For this purpose, an analysis of some variables such as age, gender, educational level, marital status, former group, family income and type of demobilization is carried out. Methodologically, a two-stage econometric binary choice model (Probit) was applied. This research found that educational level, family income and gender are the key socioeconomic determinants of economic reintegration in the population under study. Finally, the scholar community is invited to carry out studies of this type in order to understand the factors that can affect the economic re- integration of ex-combatants across the country. These analyzes provide critical information for designing more successful reintegration programs for insurgent groups, considering that Colombia is currently going through a massive demobilization process which will require a successful reintegration program that pre- vent former combatants from recidivism.
Therapeutic Potential of Decoys for Prostate Cancers: A Review of
Recent Updates
Authors: Rezaei Samaneh , Mahjoubin-Tehran Maryam , Iratni Rabah , Sahebkar Amirhossein
Published: May 2023

Prostate cancer is ranked second among the most common male cancers. Androgen
deprivation therapy (ADT) has long been the first-line treatment and the basis for
all other therapies, reducing circulating androgens to castration levels and preventing disease
development. Nevertheless, ADT monotherapy may not always limit disease development,
and even at low testosterone levels, hormone-sensitive prostate cancer will become
castration-resistant. Recent research demonstrates that prostate cancer can have a
range of potentially actionable genetic abnormalities; no medications that target these
variations have yet been shown to elicit therapeutic advantages. Despite their established
efficacy in the management of other cancers, advanced genetic or immunological approaches
are not regularly used to treat prostate cancer patients. As a result, there is an unmet
demand for medicines that offer a better chance of survival than the existing castration-
resistance prostate cancer (CRPC) therapy regimens. The use of oligodeoxynucleotides
(ODN) and peptides in decoy technology have been developed as novel therapeutic
approaches. Decoy ODNs bind to a particular transcription factor with high affinity
and may suppress gene transcription. Peptide decoys bind to specific ligands with high
specificity and inhibit signaling pathways. Recent evidence supports the notion that these
techniques are promising and attractive in the fight against cancer. In the present review,
we discuss the use of decoy technology as a novel therapeutic approach against prostate
cancer.
Multiple Protein Biomarkers and Different Treatment Strategies for
Colorectal Carcinoma: A Comprehensive Prospective
Authors: Chakraborty Biswadip , Agarwal Shivangi , Kori Shivam , Das Ratnesh , Kashaw Varsha , Iyer Arun K. , Kashaw Sushil Kumar
Published: May 2023

In this review, we emphasized important biomarkers, pathogenesis, and newly
developed therapeutic approaches in the treatment of colorectal cancer (CRC). This includes
a complete description of small-molecule inhibitors, phytopharmaceuticals with antiproliferative
potential, monoclonal antibodies for targeted therapy, vaccinations as immunotherapeutic
agents, and many innovative strategies to intervene in the interaction of
oncogenic proteins. Many factors combine to determine the clinical behavior of colorectal
cancer and it is still difficult to comprehend the molecular causes of a person's vulnerability
to CRC. It is also challenging to identify the causes of the tumor's onset, progression,
and responsiveness or resistance to antitumor treatment. Current recommendations for
targeted medications are being updated by guidelines throughout the world in light of the
growing number of high-quality clinical studies. So, being concerned about the aforementioned
aspects, we have tried to present a summarized pathogenic view, including a brief
description of biomarkers and an update of compounds with their underlying mechanisms
that are currently under various stages of clinical testing. This will help to identify gaps or
shortfalls that can be addressed in upcoming colorectal cancer research.