bluuebunny/crossref_metadata_2025 huggingface dataset:
ABOUT LINGUISTIC SUBJECTIVITY. THE SOVIET PRESS AND THE RUSSIAN PRESS
Authors: Chepiga Valentina P.
Published: January 2022

This article highlights certain peculiarities linked to linguistic subjectivity in the Soviet and Russian press covering periods in the life of society: the Soviet years until 1985, the perestroika (1985-1991), the “democratic” years. (until 1999), current life. In a journalist’s work, the recourse to subjectivity remains his main tool. However, in journalistic work, the subject of the speech is capable of making not only subjective assertions but objective assertions too. The general peculiarity of totalitarian language is its ideological component, its politicization. Usual language standards acquire a dogmatic character. After the perestroika, which lasted from 1985 to 1991, we see a rapid and abrupt renewal of the language of the media. Currently, we are witnessing media stylization in Russia again. Some subjective emotionality comes into play, on the scale of current values. Thus, each era has its vision of the ideal author: the author-journalist is made up of two entities, social and private. The Soviet period put in the foreground the social component (the explicit us), the period of perestroika and Yeltsin, the individual, private component (the explicit I), the current period, again, the implicit social component where an I hides an us.
ELEMENTS OF SEMIOTIC ANALYSIS OF RUTH SCHRANZ RATINGEN’S PAINTING
Authors: MARILLAUD Pierre
Published: January 2022

Our analysis consists of one approach of planar semiotics presented and thoroughly explained in chapter 9 of “Précis de Sémiotique Générale” by Jean-Marie Klinkenberg (1996) with a nod to other references. It goes without saying that we suggested our personal remarks and points of view in such analysis. The reason for writing this article is due to our persuasion that the importance of signs, even if it has been increasing since the past, is of such high level nowadays and that our society lives in day-to-day proliferation of images of different sorts. In our research, we have established relations between sign and linguistic structures like narrativity, for instance. However, it is utmost obvious that processes of sense construction are different whether we study a text or an image. Given an intention for our approach to be the most objective, we took into consideration the fact that spectator’s subjectivity interferes with esthetic considerations and we tried to highlight the importance of cultural influence in conception and interpretation of a painting. We did not want to limit our findings to the old idiom “tastes differ”. We hope that we were able to avoid that as well as to clarify our approach with the application of A. J. Greimas’ semiotic square.
A Review on the Arylpiperazine Derivatives as Potential Therapeutics for
the Treatment of Various Neurological Disorders
Authors: Kumar Bhupinder , Kumar Naveen , Thakur Amandeep , Kumar Vijay , Kumar Rakesh , Kumar Vinod
Published: January 2022

Neurological disorders are disease conditions related to the neurons and central nervous system (CNS). Any structural, electrical, biochemical, and functional abnormalities in neurons can lead to various types of disorders, like Alzheimer’s disease (AD), depression, Parkinson’s disease (PD), epilepsy, stroke, etc. Currently available medicines are symptomatic and do not treat the disease state. Thus, novel CNS active agents with the potential to completely treat an illness are highly de-sired. A range of small organic molecules is being explored as potential drug candidates to cure dif-ferent neurological disorders. In this context, arylpiperazinehas been found to be a versatile scaffold and indispensable pharmacophore in many CNS active agents. Several molecules with arylpiperazine nucleus have been developed as potent leads for the treatment of AD, PD, depression, and other dis-orders. The arylpiperazine nucleus can be optionally substituted at different chemical structures and offer flexibility for the synthesis of a large number of derivatives. In the current review article, we have explored the role of various arylpiperazine containing scaffolds against different neurological disorders, including AD, PD, and depression. The structure-activity relationship studies were con-ducted for recognizing potent lead compounds. This review article may provide important insights into the structural requirements for designing and synthesizing effective molecules as curative agents for different neurological disorders.
Antiviral, Anticancer and Hypotensive Potential of Diphyllin Glycosides and their Mechanisms of Action
Authors: Nekrakalaya Bhagya , Ramaiah Chandrashekar Konambi
Published: January 2022

Diphyllin glycosides (DG) are a type of arylnaphthalene lignans isolated from different plants, and their synthetic derivatives have shown effective antiviral, cytotoxic, hypotensive and diuretic effects at very low concentrations similar to standard drugs that are under clinical use. The biological activities of the DG interfere with signaling pathways of viral infection and cancer induction. The sugar moieties of DG enhance bioavailability and pharmacological activities. The promising results of DG at nanomolar concentrations under in vitro and in vivo conditions should be explored further with clinical trials to determine its toxic effects, pharmacokinetics and pharmacodynamics. This may help identify suitable antiviral and anticancer drugs in the near future. Considering all these activities, the present review is focused on the chemical aspects of DG with a detailed account of the mechanisms of action of DG. An attempt is also made to comment on the status of clinical trials involving DG along with the possible limitations in studies based on available literature till September 2020.
Immunotherapy for Gastroesophageal Tumors: Is there still Hope for
Efficacy?
Authors: Ilhan-Mutlu Aysegul , Puhr Hannah Christina
Published: January 2022

Immunotherapy represents one of the biggest breakthroughs of the 21st century and redefined
modern cancer treatment. Despite this new approach changing the treatment paradigm in
various cancer entities, including lung and head-and-neck cancer, the efficacy of these treatment
regimens varies in different patient subgroups, and so far, these treatment regimens have failed to
meet the high expectations of gastroesophageal cancer patients. This review discusses new treatment
approaches concerning immunotherapy in gastroesophageal cancer patients and sheds some
light on ongoing trials and new treatment combinations.
The Impact of MicroRNAs in Neonatal Necrotizing Enterocolitis and other Inflammatory Conditions of Intestine: A Review
Authors: Maheshwari Akhil , Donda Keyur , Bose Tanima , Dame Christof
Published: January 2022

The understanding of necrotizing enterocolitis (NEC) etiopathogenesis is incomplete, contributing to the lack of early biomarkers and therapeutic options. Micro RNAs (miRNAs) are a class of RNAs that can alter gene expression and modulate various physiological and pathological processes. Several studies have been performed to evaluate the role of miRNA in the pathogenesis of NEC. In this article, we review the information on miRNAs that have been specifically identified in NEC or have been noted in other inflammatory bowel disorders that share some of the histopathological abnormalities seen frequently in NEC. This review highlights miRNAs that could be useful as early biomarkers of NEC and suggests possible approaches for future translational studies focused on these analytes. It is a novel field with potential for immense translational and clinical relevance in preventing, detecting, or treating NEC in very premature infants.

Impact:

• Current information categorizes necrotizing enterocolitis (NEC) as a multifactorial disease, but microRNAs (miRNAs) may influence the risk of occurrence of NEC. • MiRNAs may alter the severity of the intestinal injury and the clinical outcome of NEC. • The literature on intestinal diseases of adults suggests additional miRNAs that have not been studied in NEC yet but share some features and deserve further exploration in human NEC, especially if affecting gut dysbiosis, intestinal perfusion, and coagulation disorders.
Vital Bioactive Compounds Present in Punica granatum Peel and Its Functional Effects on Human Health
Authors: Noor Uroosa , Soni Shashi , Gupta Ena
Published: January 2022

Inclination of the world towards natural and super foods have intended the researchers and nutritionist to develop foods that are highly nutritious, feasible, eco-friendly as well as can act as an immuno-booster. Massive amounts of agro-industrial waste generation throughout the world have drawn attention for its utilization and transformation from waste to wealth. A healthy Indian diet includes food from all food groups in which one-fourth part of diet is covered by fruits and vegetables. Pomegranate (Punica granatum) and its various parts are one amongst the most familiar fruit for its therapeutic applications and wonderful flavor since traditional times. Million tons of pomegranate peels are produced per annum around the world and is a considerable source of phytochemicals, vitamins, minerals, and numerous bioactive compounds like phenolics, flavonoids, anthocyanins, flavonols, flavones etc. Consequently, providing many health benefits like cardio-protective, nephro-protective, hepato-protective, anticancer, antimutagenic, antidiabetic, antimicrobial, anti-inflammatory, antioxidative and many other chronic diseases. Its safety and efficacy for consumption had been proved by the incorporation in food products and industrial applications. The main aim of this chapter is to focus on the presence of vital bioactive compounds in pomegranate peel and their functional benefits on human health.
An Exploration of ChCl/Glycerol-Based Deep Eutectic Solvent as a Sustainable
Reaction Medium for the Synthesis of Biologically Important
Aminopyrazole and Aminopyrazolone Compounds
Authors: Bhirud Jayashri D. , Gupta Gaurav R. , Narkhede Hemant P.
Published: January 2022

Objectives:

the synthesis of 4-((1-phenyl-3-(substitutedphenyl)-1h-pyrazol-4-yl) methylene)-
4h-pyrazol-3,5-diamine and 3-amino-4-((1-phenyl-3-(substitutedphenyl)-1h-pyrazol-4-yl)
methylene)-1h-pyrazol-5(4h)-one was designed and performed very aptly in deep eutectic solvent
system.

Methods:

the utilization of deep eutectic solvent (des) system chcl/gly (1:2) in the absence of hazardous
organic co-solvents, an efficient multicomponent one-pot synthetic strategy has been advanced.
In addition to that, from the perspectives of sustainable developments in organic synthesis,
the deep eutectic solvent system was recovered and very efficiently reused up to four cycles.

Results:

it has been observed that the efficacy of the deep eutectic solvent was decreased after the
second cycle, which has a measurable impact on the yield of the reaction.

Conclusion:

furthermore, the synthesized aminopyrazole and aminopyrazolone compounds were
screened as antibacterial and antifungal agents.
Therapeutic Status of Famotidine in COVID-19 Patients: A Review
Authors: Mohseni Moein , Raissi Vahid , Sharifan Yasamin , Barikro Kimia , Amiri Sasan , Mohseni Maedeh Sadat , Raeisi Farid , Masoumi Kimia , Khodakarami Sina , Raiesi Omid
Published: January 2022

The novel coronavirus, SARS-coV-2, which emerged in Wuhan in November 2019, has increasingly spread worldwide. More than 272 million cases of infection have been identified. COVID-19 has affected 223 countries and territories across the world. The principal target of the SARS-CoV-2 infection is the lower respiratory tract. Series of moderate to non-specific severe clinical signs and symptoms appear two to fourteen days after exposure to SARS-CoV-2 in patients with COVID-19 disease, including cough, breath deficiency, and at least two of these symptoms: headache, fever, chills, repeated rigor, myalgia, oropharyngitis, anosmia, and ageusia. No therapeutic agents have been validated to have substantial efficacy in the clinical care of COVID-19 patients in large-scale trials, despite worsening infected rates of COVID-19. Early clinical evidence from many sources suggests that treatment with famotidine may decrease COVID-19-related morbidity and mortality. The mechanism by which famotidine could improve the outcomes of COVID-19 is currently unknown. A more recent postulated mechanism is that the effect of famotidine is mediated by histamine-2 receptor antagonism or inverse agonism, inferring that the SARS-CoV-2, resulting in COVID-19 infection, at least partially leads to the abnormal release of histamine and perhaps dysfunction of mast cells.
Geometric Analysis of 3D Facial Image Data: A Survey
Authors: Fang Shiaofen , Wang Hao
Published: January 2022

Background:

3D facial image data has become an important data source in many biometric computing applications due to the increasing availability of 3D surface image collection technologies.

Objective:

In this survey paper, we aim to review recent advances in 3D geometry-based techniques for facial image analysis and their roles in several critical applications.

Method:

We first study the 3D facial landmark detection techniques which are often required for many facial data analysis applications. We then review the literatures related to several critical 3D facial image based applications including face recognition, medical diagnosis, and 3D face reconstruction.

Conclusion:

Our review shows that while 3D facial image data has been widely used as an important biometric data source, critical solutions still need to be developed in applications that require substantial understanding of the underlying anatomic and geometric structures of human faces.
Clinical Application of a High Sensitivity BGO PET/CT Scanner: Effects
of Acquisition Protocols and Reconstruction Parameters on Lesions Quantification
Authors: Monaco Lavinia , De Ponti Elena , Crivellaro Cinzia , Morzenti Sabrina , Todde Sergio , Landoni Claudio , Elisei Federica , Musarra Monica , Guerra Luca
Published: January 2022

Aims:

The aim of this retrospective study was to investigate SUVs variability with respect
to lesion size, administered dose, and reconstruction algorithm.

Background:

SUVmax and SUVpeak are influenced by technical factors as count statistics and reconstruction
algorithms.

Objective:

To fulfill the aim, we evaluated the SUVs variability with respect to lesion size, administered
dose, and reconstruction algorithm (ordered - subset expectation maximization plus point
spread function option - OSEM+PSF, regularized Bayesian Penalized Likelihood - BPL) in a 5 -
rings BGO PET/CT scanner.

Method:

Discovery IQ scanner (GE Healthcare, Milwaukee, Wisconsin, US) was used for list
mode acquisition of 25 FDG patients, 12 injected with 3.7 MBq/kg (Standard Dose protocol - SD)
and 13 injected with 1.8 MBq/kg (Low Dose protocol - LD). Each acquisition was reconstructed at
different time/FOV with both OSEM+PSF algorithm and BPL using seven different beta factors.
SUVs were calculated in 70 lesions and analysed in function of time/FOV and Beta. Image quality
was evaluated as a coefficient of variation of the liver (CV - liver).

Result:

SUVs were not considerably affected by time/FOV. However, SUVs were influenced by
beta: differences were higher in small lesions (37% for SUVmax, 15% for SUVpeak) compared to larger
ones (14% and 6%). CV - liver ranged from 6% with Beta-500 (LD and SD) to 13% with Beta-
200 (LD). CV - liver of BPL with Beta-350 (optimized for clinical practice in our institution) in
LD was lower than CV - liver of OSEM+PSF in SD.

Conclusion:

When a high sensitivity 5 - rings BGO PET/CT scanner is used with the same reconstruction
algorithm, quantification by means of SUVmax and SUVpeak is a robust standard compared
to the activity and scan duration. However, both SUVs and image quality are influenced by reconstruction
algorithms and the related parameters should be considered to obtain the best compromise
between detectability, quantification, and noise.
Analysis of mathematical spatial ability in terms of choleric and melancholic personality types in junior high school students
Authors: Listiwikono Eko
Published: January 2022

Mathematics is one of the subjects that occupies an important role in the world of education. Geometry is a part of mathematics that can hone spatial skills. Variations in spatial abilities differ in students depending on personality type. The purpose of the study was to determine the students' mathematical spatial ability in terms of choleric and melancholic personality types in geometry. This type of research is qualitative research with data obtained through questionnaires, tests, and interviews. Data were analyzed by data triangulation. From this data, it is analyzed and triangulation process is carried out. The results showed: (1) the mathematical spatial abilities of students with choleric personality were categorized as good, which were able to identify, classify, imagine, construct and present geometric shapes and have not been able to state the position of the elements; (2) The mathematical spatial ability of students with melancholic personality types, namely being able to state the position of the elements of a spatial structure, being able to identify, classify, imagine a shape or position, be able to construct and represent a spatial image and be able to investigate a spatial image.
A vida de um legendário depois da morte do autor (Fr. Diogo do Rosário, 1585)
Authors: Sobral Cristina
Published: January 2022

Fr. Diogo do Rosário was the author of the first legendary printed after the Council of Trent (Historia das vidas e feitos heroicos, e obras insignes dos Sanctos, Braga, António de Mariz, 1567). After his death, in 1580, the work will continue to spread, having its third edition and first posthumous in 1585: Historia das vidas e feitos heroicos, e obras insignes dos Sanctos (...) Agora nesta ultima impressam emendado cõ muita diligencia e acrecentado de algũas vidas de sanctos, Lisbon, António Ribeiro. Following previous works in which I analyzed the 1567 edition, in this article I analyze the first stage of the evolution of the legendary, what changes were made to the corpus and the criteria used in the rewriting of the texts.
Experiencing food in Anne of Saint Bartholomew ( 1549-1626)
Authors: Sanmartín Bastida Rebeca
Published: January 2022

The Blessed Ana de San Bartolomé (1549-1626) is a famous disciple of Saint Teresa of Avila who devoted much attention to food in her prolific writings (letters, autobiographies, declarations, meditations, prayers...). The role that food plays in her life interests us in several ways: her conception of the prioress as a breastfeeding mother; her cannibal understanding of Saint Teresa’s relics; her ambivalent relationship with fasting; and finally, her broad description of conventual food, which help us to better understand how 16th to 17th centuries diets were conformed.
Hagiografia(s) no século XXI algumas leituras, difusas “visões” e breves interrogações
Authors: Leal Luís
Published: January 2022

There is a consensus among researchers of multiple epistemological sensibilities that contemporaneity, sometimes interpreted as post-modernity or as hiper-modernitity, manifests itself as marked by a very wide range of sociocultural phenomena that cannot be disregarded by the attentive eye of the historian and/or hagiographer, latu sensu considered. Among such phenomena, the advent of the “Web 2.0/3.0” acquires particular importance, specifically in what it means in the context of experiences and expressions of contemporary spirituality/religion, increasingly framed in a “(so-called) digital religion”. Thus, adopting the present reflection a hagiographic focus on such phenomena, it is intended to underline such influx and to suggest some possible consequences of this growing immersion in the “digital world” by the contemporary homo religiosus. After an initial clarification of concepts considered fundamental to the proposed analysis, and where the contributions of Zygmunt Bauman, Gilles Lipovetsky and Pierre Lévy are invoked, some “epiphenomena” – here considered paradigmatic – of the referred influx and which point to further consideration are analyzed. Finally, and although not exhaustively, some of the “questions” that the described panorama raises are listed, particularly in the framework of hagiographic analysis proposed.
O Mistério do Fidalgo de Chaves (Um Português em Roma, 1510 – 1517)
Authors: Albuquerque Martim de
Published: January 2022

This study aims to unravel the mistery surrounding the Fidalgo de Chaves, highlighting the importance of the Tratado que hû criado do duque de braguãça escreveo pera sua sñoria dalgûas notavees cousas que vio hindo pera Roma [...] in the frame of the history of Portuguese culture in the Renaissance and its relations with Italy.
D. António de S. José de Castro. Reconstrução liberal de uma biografia
Authors: Tavares Pedro Vilas-Boas
Published: January 2022

Based on the documentary elements used by him in the biographical sketch of this personality, so decisive in the success of the Portuguese anti-Napoleonic resistance, the author proposes to emphasize, with some concrete examples, how much the historical profile of this antisitis remained, for reasons of mere sectarian politics , surgically at the mercy of its systematic disfigurement by the followers of the radical liberal sector, committed and naturally opposed to any attempt at reformist evolution and illustrated by the institutional legality in force. A replica and reflection – after all – of what, in terms of historical memory, was intended with king John VI, a statesman only late and still incompletely rescued from the incomprehension and injustice of the assessments to which he was voted.
O Espelho das Virtudes Os bispos jacobeus e o projeto de reforma do clero secular – América portuguesa (1725-1773)
Authors: Mendes Ediana Ferreira
Published: January 2022

This article aims to discuss the reform of the secular clergy planned by the Jacobeu bishops in Portuguese America. Thus, the origin of the spirituality chain called Jacobeia will be briefly examined, as well as the role played by the forerunner of the chain, Friar Francisco da Anunciação, and the main directives of the movement in order to glimpse the influences of these principles considering the model of a perfect clergy outlined by these prelates and the measures aimed at the reform and discipline of secular clergy.
Os benefícios da Eucaristia para a alimentação das almas no Brasil colonial
Authors: Santos Clara Braz dos
Published: January 2022

During the 17th and 18th centuries, several ecclesiastical scholars who worked in Brazil, especially Jesuits, produced a series of writings of a moral, doctrinal or prescriptive nature - sermons, books of devotion, manuals for good death, manuals of confession, manuals for slave masters, synodal constitutions, spiritual regiments - which had as one of the main goals the care of the soul, highlighting the references to the Eucharist as a fundamental sacrament for the nourishment of Catholics’ spirit. In view of the importance that these edifying, instructive or prescriptive works had in the modern period and, especially, in colonial Brazil, to guide the souls and actions of the faithful towards a virtuous and morally good life, and the emphasis given to the Eucharist as appropriate food for the sustenance of souls and for the guarantee of good Catholic behavior, the purpose of the article will be to examine, in these writings, the main benefits of the body and blood of Jesus Christ for souls and how such benefits could be guaranteed by the faithful from the tropics.
A consolidação das fronteiras na América Portuguesa: assentamento dos lavradores de cana na expansão para o Oeste (Campinas, SP, 1790-1810)
Authors: Nicolette Carlos Eduardo
Published: January 2022

The frontiers of Portuguese America were in movement throughout the colonial period, as occurred in Minas Gerais. However, after the revolution of enslaved people in Saint-Domingue in 1791 and the consequent increase in sugar prices in international markets, there was an intense migratory flow to the colony’s unoccupied, uninhabited regions. It was in this historical framework that Campinas, countryside of São Paulo, witnessed its free population increase by more than five times in addition to the slave population being increased by ten times. Thus, this article aims to investigate the migration of sugar producers to Campinas and to understand how the origins of these individuals explain the formation of this sugar production complex. In this sense, there was a considerable migration of descendants of the colonial elite, especially those born in Itu and Minas Gerais
Efeito da temperatura na mortalidade por doenças cardiovasculares na província de Saragoça (Espanha), 1920-1950
Authors: Fernandes Milene dos Anjos , Marco-Garcia Francisco J.
Published: January 2022

The relationship between cardiovascular health and climatic conditions is a central issue of cardiological research in order to face the global warming challenge. This article analyses 15 locations in rural Spain between 1920 and 1950. The main objective is to know how temperature affected mortality due to cardiovascular causes in a historical context. Based on historical data on the cause of death, age, sex, time of death and temperature, an analysis has been carried out using descriptive statistics and MLS regressions to determine the effects of extreme temperatures on cardiovascular health. The results evidence that mortality from cardiovascular causes was concentrated on the coldest and hottest days of the year, and on subsequent days, being especially important in the case of deaths from ischemic heart disease. There is a pattern of summer-winter differentiated mortality depending on the hottest and coldest hours of the day.
Encenar a nação — a diplomacia cultural do Estado Novo português através dos Centros de Informações de Genebra e Roma
Authors: Ribeiro Carla
Published: January 2022

This article examines the efforts of Portuguese cultural diplomacy abroad in the aftermath of World War II. Drawing on the concept of soft power theorised by Joseph Nye, the research focuses on the first Portuguese Information Centres, in Geneva and Rome, created by the Portuguese Minister in these cities, António Ferro. Drawing mainly on unpublished documentary sources from the National Secretariat for Information fund in the National Archive, the aim was to shed light on its organisation, its relationship with central government, and to examine the activities undertaken and the results achieved. The working hypothesis was that the Centres functioned in a logic of defence of the nation, part of a strategy to «seduce» a post-war democratised Europe, confronted with the Portuguese dictatorship, which persisted in maintaining a Colonial Empire
DIREITO E DEMOCRACIA E O PAPEL DO ENSINO JURÍDICO
Authors: Mello Marco Aurélio
Published: January 2022

Este artigo tem como objeto a relação Direito e democracia, considerados o constitucionalismo e a atuação do Judiciário, bem como a importância do ensino jurídico para a solução de conflitos que venham a surgir. Na primeira parte, é apresentado o conceito de democracia. Na segunda, discorre-se sobre a relação com o Direito à luz da ideia de constitucionalismo e da jurisdição constitucional. Na terceira, é examinado o papel do ensino jurídico, e, particularmente, da Faculdade Nacional de Direito, na formação de profissionais e cidadãos comprometidos com os valores preconizados pela Lei Maior.
AS RAÍZES DA FACULDADE NACIONAL DE DIREITO DA UFRJ: “WEBINAR DE 130 ANOS: NOS MEUS TEMPOS DE FND” E O EVENTO “TRAJETÓRIAS E ENREDOS DE LUTA: 130 ANOS DA FND”
Authors: Cesário Kone Prieto Fortunato , Ferreira Rondinelle da Silva
Published: January 2022

Este ensaio é parte do projeto de um dossiê sobre os 130 anos da Faculdade Nacional de Direito da Universidade Federal do Rio de Janeiro. Tendo como referência contar como importantes eventos que marcam parte da celebração dos 130 da Nacional de Direito, buscando a perspectiva de uma docente e um discente, dentro da temática de direito e democracia, após trinta e dois anos da primeira eleição direta no Brasil, mas em um  período de ameaça à democracia, envolta em dificuldades do encontradas em meio de uma Pandemia mundial e uma polarização da sociedade em torno de temas políticos e sociais.
A “CRIAÇÃO” DA FACULDADE DE DIREITO DA UFRJ (FND) E O ENSINO JURÍDICO NO BRASIL EM 1891: estudo analítico de aspectos da Reforma Benjamin Constant referentes às Faculdades Livres
Authors: Alves Alexandre Ferreira de Assumpção
Published: January 2022

Elabora-se o presente o artigo no ano em que a Faculdade de Direito da UFRJ, conhecida por seus alunos e ex-alunos como “FND”, comemora 130 (cento e trinta) anos do início de suas atividades, na condição de docente ex-aluno integrante da “turma centenário” (denominação recebida em razão da conclusão do curso de bacharelado no ano do centenário).
O COMBATE A TRANSFOBIA NA AGENDA DE POLÍTICAS PÚBLICAS DE SEGURANÇA NO BRASIL: cenário atual e desafios
Authors: Cavalcante Rodrigues José Welhinjton , Silva Nogueira Barbosa Bruno Rafael , Vieira da Siva Laionel
Published: January 2022

A segurança de travestis e transexuais está em risco no Brasil, país esse que mais mata esse grupo vulnerável no mundo. Assim, o objetivo do presente trabalho é analisar os desafios que se apresentam hoje para a inserção do combate a transfobia na agenda do governo brasileiro. Utilizando do raciocínio dedutivo, do tipo de pesquisa qualitativa, da abordagem documental conjugada da revisão bibliográfica, observou-se que o Movimento LGBT no Brasil tem influenciado a elaboração de políticas públicas de segurança para trans nas últimas décadas, porém ainda de maneira bastante insuficiente. O resultado disso é a negação de direitos humanos as pessoas trans e o consequente genocídio que esse grupo sofre.
INCONSTITUCIONALIDADE DAS DELEGAÇÕES DE COMPETÊNCIA DE CONSELHOS PROFISSIONAIS A SOCIEDADES CIVIS E DIREITO AO TRABALHO
Authors: Souza Luciana Cristina de , Diniz Felipe Lécio Oliveira Cattoni
Published: January 2022

O artigo enfrenta o problema de controle de competências próprias de autarquias por sociedades civis. Realiza um estudo de caso por meio da revisão da Resolução n. 1.634/2002. Na pesquisa foram aplicados o método dedutivo na análise conceitual das doutrinas constitucional e de direito administrativo, assim como levantamento jurisprudencial e legislativo relativo ao tema. A metodologia jurídico-compreensiva contribui nesse estudo para amparar os argumentos que amparam a defesa da hipótese em tela de inconstitucionalidade das delegações de restrição de uso da liberdade profissional a órgãos outros que não pertençam à Administração Pública.
A DOGMÁTICA EM DEBATE: FRANZ NEUMANN E AS POSSIBILIDADES EMANCIPATÓRIAS NO MÉTODO JURÍDICO
Authors: Vick Fernanda
Published: January 2022

Este artigo busca estabelecer um conjunto de ideias para avançar debates sobre o método jurídico no campo do direito e das políticas públicas, tomando por ponto de partida a lacuna de abordagens sobre a dogmática jurídica. O artigo apresenta os pressupostos e as regras do jogo sobre o saber e o fazer dos juristas, situando o discurso de crise da dogmática, deflagrado com o advento das políticas públicas, como limite de perspectiva. O artigo situa o debate da dogmática jurídica no desenvolvimento do direito liberal a partir da crítica de Franz Neumann em “O Império do Direito” (2013; Rodriguez 2009, 2012), cuja perspectiva procedimental propõe não apenas uma tarefa emancipatória para o direito, como também o seu método, como referência para a crítica da dogmática e das doutrinas jurídicas. Como abordagem para avançar estudos internos e interdisciplinares, apresenta a racionalidade do método jurídico para apreensão da realidade social e suas categorias elementares – os sujeitos e as relações jurídicas – demonstrando que o raciocínio jurídico é desenvolvido para a ação atomizada ou individualizada, o que explica dificuldades e dilemas nas tarefas das políticas públicas, sua dimensão institucional e agregada.
Balance Between Delegation of Authority and Submission of Regional Revenue Sources in Indonesia
Authors: Khairi Halilul
Published: January 2022

Since 1946, Indonesia has adopted a decentralization policy that impacts the transfer of authority to regulate and administer government affairs in the regions, followed by financing to manage these affairs. In a unitary state, the power source, both in terms of financial management and administrative power, rests with the central government. This study uses a descriptive qualitative method to explain the history of the development of authority and financial balance policies in Indonesia and the meaning of decentralization policies in Indonesia. Quantitative descriptive was used to analyze data regarding the implementation of regional government affairs, personnel expenditure ratios, comparison of central and regional expenditures, and other data related to burdens and revenues between the center and the regions. This study found that the central government has recognized regional independence through income sources managed by themselves and reduced transfer funds that aim to cover the lack of regional revenues. The provision of sources of revenue from the central government to the regions is not proportional to the ratio of the burden given. The results of this study indicate that the load is inversely related to the budgetary capacity between the government and local governments. The imbalance between the workload and the source of revenue received by the region is the low ability of the region to provide basic services that are the authority.
Digital Life Coaching During Stem Cell Transplantation: Development and Usability Study
Authors: Banerjee Rahul , Huang Chiung-Yu , Dunn Lisa , Knoche Jennifer , Ryan Chloe , Brassil Kelly , Jackson Lindsey , Patel Dhiren , Lo Mimi , Arora Shagun , Wong Sandy W , Wolf Jeffrey , Martin III Thomas , Dhruva Anand , Shah Nina
Published: January 2022

Background

For patients with multiple myeloma receiving high-dose chemotherapy followed by autologous stem cell transplantation (SCT), acute life disruptions and symptom burden may lead to worsened quality of life (QOL) and increased emotional distress. Digital life coaching (DLC), whereby trained coaches deliver personalized well-being–related support via phone calls and SMS text messaging, has been shown to improve QOL among SCT survivors. However, DLC has not been investigated during the acute peri-SCT period, which is generally characterized by symptomatic exacerbations and 2-week hospitalizations.

Objective

We launched a single-arm pilot study to investigate the feasibility of patient engagement with DLC during this intensive period.

Methods

We approached English-speaking adult patients with multiple myeloma undergoing autologous SCT at our center. Enrolled patients received 16 weeks of virtual access to a life coach beginning on day −5 before SCT. Coaches used structured frameworks to help patients identify and overcome personal barriers to well-being. Patients chose the coaching topics and preferred communication styles. Our primary endpoint was ongoing DLC engagement, defined as bidirectional conversations occurring at least once every 4 weeks during the study period. Secondary endpoints were electronic patient-reported outcome assessments of QOL, distress, and sleep disturbances.

Results

Of the 20 patients who were screened, 17 (85%) chose to enroll and 15 (75%) underwent SCT as planned. Of these 15 patients (median age 65 years, range 50-81 years), 11 (73%) demonstrated ongoing DLC engagement. The median frequency of bidirectional conversations during the 3-month study period was once every 6.2 days (range 3.9-28 days). During index hospitalizations with median lengths of stay of 16 days (range 14-31 days), the median frequency of conversations was once every 5.3 days (range 2.7-15 days). Electronic patient-reported outcome assessments (94% adherence) demonstrated an expected QOL nadir during the second week after SCT. The prevalence of elevated distress was highest immediately before and after SCT, with 69% of patients exhibiting elevated distress on day −5 and on day +2.

Conclusions

DLC may be feasible for older patients during intensive hospital-based cancer treatments such as autologous SCT for multiple myeloma. The limitations of our study include small sample size, selection bias among enrolled patients, and heterogeneity in DLC use. Based on the positive results of this pilot study, a larger phase 2 randomized study of DLC during SCT is underway to investigate the efficacy of DLC with regard to patient well-being.

Trial Registration

ClinicalTrials.gov NCT04432818; https://clinicaltrials.gov/ct2/show/NCT04432818.
Gender Differences and Associated Factors Influencing Problem Gambling in Adolescents in Sweden: Cross-sectional Investigation
Authors: Claesdotter-Knutsson Emma , André Frida , Fridh Maria , Delfin Carl , Håkansson Anders , Lindström Martin
Published: January 2022

Background

Although gambling disorder is traditionally considered an adult phenomenon, the behavior usually begins in childhood or adolescence.

Objective

The aim of this study was to explore the frequency of problem gambling among Swedish adolescents and the suspected associated factors.

Methods

This study was based on data collected through a public health survey distributed in 2016 to pupils in ninth grade of primary school and in second grade of secondary school in Sweden. Bayesian binomial regression models, with weakly informative priors, were used to examine whether the frequency of the associated factors differed between those with and without problem gambling.

Results

Approximately 11.7% (469/4002) of the boys in ninth grade of primary school and 13.9% (472/3407) of the boys in second grade of secondary school were classified as problem gamblers. For girls, the corresponding frequencies were 1.2% (48/4167) and 0.7% (27/3634), respectively. The overall response rate was 77% (9143/11,868) among ninth grade pupils and 73.4% (7949/10,832) among second grade pupils, resulting in a total of 17,092 responses. Problem gambling was associated with poor sleep and having tried smoking, alcohol, and other substances among both boys and girls in ninth grade of primary school and boys in second grade of secondary school. Problem gambling among girls in second grade of secondary school was associated with an increased prevalence of having tried smoking and other substances and an increased prevalence of poor sleep.

Conclusions

Using a large representative sample of Swedish adolescents, we found that problem gambling was robustly associated with a substantially increased prevalence of poor sleep and having tried smoking, alcohol, and other substances among both boys and girls in ninth grade of primary school as well as among boys in second grade of secondary school. Our study adds important information for policy makers pointing at vulnerable groups to be considered in their work to prevent problem gambling.
Young Adults’ Use of Different Social Media Platforms for Health Information: Insights From Web-Based Conversations (Preprint)
Authors: Lim Megan S C , Molenaar Annika , Brennan Linda , Reid Mike , McCaffrey Tracy
Published: January 2022

BACKGROUND

Social media–delivered health promotion has demonstrated limited uptake and effectiveness among young adults. Understanding how young adults interact with existing social media platforms for health might provide insight for future health promotion interventions.

OBJECTIVE

The aim of this study is to describe how young adults interact with different social media platforms for health and health information.

METHODS

We used a web-based conversation methodology to collect data from 165 young adults aged 18 to 24 years. Participants participated in an extended conversation with moderators and other participants about health and social media. They were prompted to discuss how they find health information, how they use different social media platforms, and how they evaluate the trustworthiness of information. A thematic qualitative analysis was applied to the data.

RESULTS

Young adults spent a lot of time scrolling through Facebook newsfeeds, which often resulted in seeing health-related content either from their friends, news sources, or advertisements. Some actively sought out information about specific health areas by joining groups or following relevant pages. YouTube was considered a useful source for learning about everything and was often the go-to when searching for information or advice (after Google). Young adults found the video format easy to learn from. They stated that they could identify accurate YouTube health content by cross-checking multiple videos, by feeling that the presenter was real and relatable, or just through instinctively judging a video’s credibility. Instagram was a source of inspiration for health and wellness from those whose lives were dedicated to healthy lifestyles and fitness. Twitter, Tumblr, and Snapchat were rarely used for health information.

CONCLUSIONS

Most young adults obtain health information from social media, both actively and through passive exposure. Participants indicated looking to social media influencers for health and lifestyle inspiration and judged the credibility of sources by appearance and instinct. Health experts should try to use the channels in the way that young adults already use them; use relatable role models on Instagram and YouTube, eye-catching headlines and support groups on Facebook, and easy to follow instruction videos via YouTube.

INTERNATIONAL REGISTERED REPORT

RR2-10.1111/1747-0080.12448
eHealth literacy and technology acceptance among middle-aged and older adults with chronic disease in rural Taiwan: a cross-sectional correlation study (Preprint)
Authors: Chao Li Fen
Published: January 2022

BACKGROUND

Electronic-health technology is recognized as a valuable tool that facilitates health care delivery. Understanding usage trends of electronic-health systems amongst diverse populations provides insight that can be used to enhance the adoption of these technologies.

OBJECTIVE

To investigate the relationship between electronic-health literacy, electronic-health technology acceptance and socio-demographic characteristics and patient portal usage among middle-aged and older adults with chronic diseases.

METHODS

A cross-sectional study was conducted with convenience sampling. Three questionnaires were administered: a patient portal usage survey; the eHealth Literacy Scale; and an eHealth Technology Acceptance questionnaire. Pearson correlations and multiple regressions were used.

RESULTS

In total, 120 participants were recruited. Patient portal usage was infrequent, 45% of participants had never used the patient portal. The findings showed low eHealth Literacy Scale scores and eHealth Technology Acceptance scores, both with a mean score of 2.59 out of 5. Factors such as age, living arrangement, primary caregiver, educational level, vision, number of smart products owned and internet connection showed an association with eHealth literacy (P<.05). Gender, monthly income, and educational level were shown to affect eHealth technology acceptance (P<.05). Additionally, eHealth literacy had a significant impact on eHealth technology acceptance (P<.001); the explanatory power was 66.7%.

CONCLUSIONS

Incorporating older adults into the design and development of similar electronic-health tools could help address the various user experience issues and barriers to use that middle age and older adult populations face.
Partisipasi Masyarakat dalam Pengelolaan Dana Desa: Kasus di Kabupaten Lima Puluh Kota, Provinsi Sumatera Barat
Authors: Rahmi Fatizah , Asrinaldi  , Putri Indah Adi
Published: January 2022

Pergeseran arah pembangunan top-down menjadi bottom-up menuntut pembangunan yang berpusat dari masyarakat, seperti dalam hal partisipasi pengelolaan dana desa. Partisipasi masyarakat dalam hal pengelolaan dana desa di Nagari Situjuah Gadang Kecamatan Situjuah Limo Nagari Kabupaten Limapuluh Kota berhasil mengantarkan Nagari Situjuah Gadang menjadi pengelola klinik keuangan terbaik di Kabupaten Limapuluh Kota tahun 2018. Dengan tingginya partisipasi yang berkorelasi negatif dengan indeks pendidikan serta sosial ekonomi  yang dimiliki masyarakat peneliti berasumsi bahwa partisipasi di Nagari Situjuah Gadang merupakan bentuk partisipasi dalam rekayasa sosial. Penelitian ini bertujuan untuk menjelaskan & menganalisis bentuk partisipasi masyarakat dalam pengelolaan dana desa serta mengidentifikasi dan mendeskripsikan dimensi dominan dalam partisipasi tersebut. Penelitian ini menggunakan metode kualitatif, studi kasus instrumental dengan menggunakan konsep pembangunan partisipatif dari Mansour Fakih serta 4 dimensi partisipasi dari Rusidi. Penelitian ini menemukan bahwa bentuk partisipasi masyarakat dalam pengelolaan dana desa di Nagari Situjuah Gadang Kecamatan Situjuah Limo Nagari Kabupaten Limapuluh Kota terbagi kedalam 4 dimensi, yaitu : 1) sumbangan pemikiran, 2) sumbangan materi, 3) sumbangan tenaga, 4) memanfaatkan dan melaksanakan pembangunan. Berdasarkan dimensi tersebut ditemukan bahwasanya kecenderungan partisipasi masyarakat di Nagari Situjuah Gadang dalam hal dimensi sumbangan tenaga, hal ini turut didukung dengan kondisi ekonomi yang dimiliki oleh masyarakat Nagari Situjuah Gadang.
Evaluación del Algoritmo Genético y GRASP para Minimizar el Makespan en la Programación de un Taller de Flujo en Diferentes Instancias de Número de Trabajos e Iteraciones
Authors:   Facultad Ciencias e Ingeniería, Universidad Estatal de Milagro (UNEMI), Ecuador, Paredes-Quevedo Juan , Alpala Luis ,   Grupo de Investigación Eslinga. Universidad Cooperativa de Colombia-Pasto, Colombia,   Grupo de Investigación en Informática Gráfica. Universidad de Granada, España, Soto-Chávez Luis ,   Facultad de Ingeniería Industrial. Universidad de Guayaquil, Ecuador, León-Batallas Alberto ,   Facultad Ciencias e Ingeniería, Universidad Estatal de Milagro (UNEMI), Ecuador
Published: January 2022

En este artículo se plantean algoritmos meta-heurísticos para el problema de programación de producción de un taller de flujo, considerado como un problema no polinómico completo debido a su complejidad. El estudio de la problemática es relevante dada su utilidad en la práctica, por ejemplo, en fábricas con líneas de ensamblaje o en la planificación de cadenas de suministro colaborativas. De esta manera, el objetivo del presente estudio consistió en evaluar dos algoritmos meta-heurísticos, GRASP y algoritmo genético. Se planteó un diseño experimental para determinar cuáles factores (método, número de trabajos y número de iteraciones) tienen un efecto estadísticamente significativo en el tiempo de finalización de programación de producción. Según los resultados se pudo observar que existe incidencia tanto de primer como de segundo y tercer orden de los factores, permitiendo caracterizar el desempeño de los dos algoritmos en entornos generados por la interacción de los tres factores analizados.
Review: CFD Analysis Comparison of Tapered Helical and Square Coil Heat Exchanger Bu Using Different Types of Nanofluid with Oil as Its Base Fluid in Aluminium and Copper Tube
Authors: Gupta Santosh Kumar
Published: January 2022

Abstract: The recovery of waste heat has been a topic of concern for large-scale industrial companies for several decades. This recovery not only makes an operation more environment friendly, but it also helps to cut costs. In addition to this, it can reduce the amount of resources needed to power a facility. Many industries have implemented different methods of waste heat recovery. One popular choice is using a heat exchanger. This paper presents the study of two different types of nano-fluids in two materials off heat exchangers ie.aluminium tapered helical coil heat exchanger and copper tapered helical coil heat exchanger. In this present paper the efforts are made to understand that how to compare the heat transfer rate in Copper and aluminium tapered helically coiled tube heat exchanger using different types of Nano fluid by studying research papers of various authors. Keywords: Tapered Helical Coil, Tapered Square coil, Nano-fluid, Heat Exchanger, CFD, Pressure Drop, Temperature Distribution, Aluminium and copper.