bluuebunny/crossref_metadata_2025 huggingface dataset:
Recommendations for the development of Clinical Practice Guidelines
Authors: Wachholz Patrick Alexander , Stein Airton Tetelbom , Melo Daniela Oliveira de , Mello Renato Gorga Bandeira de , Florez Ivan D.
Published: August 2022

Clinical practice guidelines are statements that include recommendations intended to optimize patient care, are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options, and ensure that the best available clinical knowledge is used to provide effective and quality care. They can reduce inappropriate care and variability in clinical practice and can support the translation of new research knowledge into clinical practice. Recommendations from clinical practice guidelines can support health professionals by facilitating the decision-making process, empowering them to make more informed health care choices, clarifying which interventions should be priorities based on a favorable trade-off, and discouraging the use of those that have proven ineffective, dangerous, or wasteful. This review aims to summarize the key components of high-quality and trustworthy guidelines. Articles were retrieved from various libraries, databases, and search engines using free-text term searches adapted for different databases, and selected according to author discretion. Clinical practice guidelines in geriatrics can have a major impact on prevention, diagnosis, treatment, rehabilitation, health care, and the management of diseases and conditions, but they should only be implemented when they have high-quality, rigorous, and unbiased methodologies that consider older adult priorities and provide valid recommendations.
The Microbiology of Cheese and Dairy Products is a Critical Step in Ensuring Health, Quality and Typicity
Authors: Focardi Silvano
Published: August 2022

Cheese and dairy products require a rigorous observation of the procedures, strictly linked to the different indigenous components, such as the initial raw materials, the process chain, the ripening temperature, the water activity (aw), the pH and the contamination of the environment and operators. Microorganisms are key agents in the transformation of milk and in the subsequent phases which confer typicity and stability to cheese and dairy products. Contamination by pathogenic microorganisms may occur, compromising the safety of the final products. Meanwhile, beneficial microorganisms present in cheese and dairy products can produce antimicrobial compounds, thus avoiding spoilage of the products, ensuring their safety for human consumption. This mini review reports a description of the microorganisms involved in the fermentation of milk and in the subsequent processes concerning cheeses and derivatives, highlighting the aspects that microorganisms play in terms of quality, typicality and safety. New aspects emerged from this study, suggesting possible insights and future research. These include cultural approaches on the one hand, which allow for the isolation and characterization of new microbial strains that confer peculiarities in terms of quality and typicality to cheeses and dairy products, and the isolation of lactic acid bacteria that produce bacteriocins as important tools for combating microbial pathogens. On the other hand, investigations on cheese and dairy products using metagenomic approaches with DNA extraction followed by amplification and sequencing of microbial genes, allow the description and monitoring of the entire microbiota involved in the transformation processes of cheese and dairy products. Therefore, the combination of cultural dairy microbiology and metagenomic approaches can lead to improving the characteristics of cheeses and dairy products, while maintaining respect for traditions.
Analysing online travel reviews to identify temporal changes of a destination image
Authors: Guo Xinxin , Pesonen Juho , Komppula Raija
Published: August 2022

The goal of this study is to examine how destination image and destination sentiment change over time using content from online travel reviews. We explore the evolution of Finland’s destination image from 2013 to 2018 by analysing 10,197 unstructured Chinese travel reviews. With a mixed analysis approach, we identify the evolutions of the perception of destination attributes, destination structure, and destination sentiment at functional, the mixed functional-psychological, and the psychological levels. The results show that the perceptions of destination attributes can evolve and change surprisingly rapidly, even in the case of a country-level destination. Although the structure of destination image seems to be stable, individual dimensions may evolve rapidly. In terms of destination sentiment, the evolving trends of destination sentiment can be even in the opposite direction of the evolution of destination attributes. These findings improve the research on the dynamic characteristics of destination image and provide industry insights for destination marketers in formulating long-term marketing strategies and monitoring destination image development.
Special Issue Section Tourman 2021 - "Restarting tourism, travel and hospitality: The day after"
Authors: Fotiadis Anestis
Published: August 2022

This guest editorial presents the papers in the Special Issue Section of the European Journal of Tourism Research from the 4th International Scientific Conference "TOURMAN 2021" (www.tourman.gr), 21-23.05.2021, entitled "Restarting tourism, travel and hospitality: The day after"
Public Health’s Call to the People: Media Misinformation Matters​
Authors: Kahane Kelila , Sherman Jenna , Patella​ Samantha
Published: August 2022

While the world wrestles with a microscopic virus, a subtler, but no less critical, battle bubbles beneath the surface: the clash between science’s granular complexity and the race for clear conclusions in journalism. Since the start of this pandemic, we have witnessed the repercussions of inflammatory language. We have also seen the dramatic adverse effects of misinformation, whether intentional or unintentional: The April 2020 myth of the virus being ‘over.’ The myth of hydroxychloroquine as cure. The myth of the futility of masks. The myth of the COVID-19 vaccine editing our DNA (Loomba et al., 2021; Hornick et al., 2021; Brunell & Maxwell, 2020).
Psychological and Behavioral Impacts of Breast Cancer on Survivors​
Authors: Davoud​ Kevin
Published: August 2022

More than 3.8 million people with a history of breast cancer were reported to be alive in 2019, and about 150,000 of these people are currently living with metastatic disease. Based on recent data, the survival rate for breast cancer survivors is 91% after 5 years, 84% after 10 years, and 80% after 15 years. The purpose of this research article is to review how breast cancer can influence patients’ mental health status while in remission and to emphasize the importance of survivorship resources for these patients after stopping intensive cancer treatment. Mental health serves as a balance of emotional wellbeing and maintaining a harmonic internal equilibrium state. However, due to intensive therapies, treatments, and post-traumatic stress, a breast cancer survivor may have difficulties with being in a healthy mental state. The causes for depression, “chemo brain”, and mood changes will be discussed in relation to breast cancer treatment and survivorship. Three resources that are crucial to helping a patient adjust to the multitude of emotions and the new “normal” in their lives have been identified: psychiatric oncologists, survivorship clinics, and personalized plans for recovery.  The review article will explore the purpose and importance of each of these resources.
Taking The Next Step: Leveraging Behavioral Economics for Health Exchange Re-Enrollees
Authors: Raman Swathi
Published: August 2022

With the recent close of the 2019 Open Enrollment Period, the federal health exchange marks the end of six tumultuous years – years characterized by recurrent system-wide crashes, highly politicized rhetoric, significant cutbacks in funding, and, most recently, a shorter 45-day enrollment window (Mangan, 2017). The Affordable Care Act (ACA) itself is facing judicial challenges that may threaten to topple the legislation (Goodnough & Pear, 2018). Despite these changes, the Centers for Medicare and Medicaid services (CMS) reports that over 8.4 million consumers have selected plans using the Healthcare.gov platform in the 2019 Open Enrollment period (November 1 – December 15, 2018), of which over 75%, or 6.4 million consumers, were existing consumers renewing their coverage (CMS Newsroom, 2018).
Legal Obstacles to Biosimilar Market Entry
Authors: Karas Laura , Sachs Rachel , Anderson Gerard
Published: August 2022

Improving the market availability and penetration of biosimilars, “follow-on” versions of biologic products, will require attention to key legal obstacles. Because biosimilars offer the potential for sizeable cost savings to payors and improved access to biologic drugs for patients, obstacles to the timely licensure and market availability of biosimilars are of major public health significance. Issues around intellectual property, potentially anticompetitive contractual arrangements with purchasers and insurers, and laws governing automatic substitution of biosimilars for biologics merit particular attention. This Article examines several key legal obstacles to biosimilar market entry in the United States, including (1) the complexity and imprecise boundaries of the exchange of patent information codified in the BPCIA; (2) patent thickets that protect biologic reference products; (3) unsettled antitrust law surrounding reverse payment patent settlements (i.e., “pay-for-delay” agreements); (4) contractual arrangements such as bundled purchase agreements and formulary exclusivity provisions; and (5) state laws that regulate substitution of biosimilars for biologics at the pharmacy level.  Strategies to address these obstacles include reforms to the patent system to curb issuance of ancillary secondary patents intended to delay competition, greater transparency around biologic patents, reconsideration of the need for a regulatory designation of interchangeability, and better detection and enforcement of deliberately anticompetitive practices.
Fomite Transmission Among Respiratory Viruses and the Importance of Low-level Surface Disinfection
Authors: L. Wiemken Timothy
Published: August 2022

Background Many different respiratory viruses cause substantial morbidity and mortality worldwide. The impact of these viruses on human health is not well understood since diagnostic testing is uncommon, available tests have modest diagnostic accuracy, and therapies are rare. This leaves infection prevention our primary resource for reduction in morbidity and mortality due to these viruses. Main Body A practical approach to prevention of respiratory virus transmission is to institute protections to reduce the risk from all sources of potential transmission. This approach is called the “swiss cheese model” and is often considered the cornerstone of quality. Although mask use has been given a great deal of discussion for respiratory virus prevention, the role of surfaces and indirect contact transmission through fomites has been largely ignored despite a great deal of supporting evidence. Fomite transmission even more critical, as it is tightly interconnected with both droplet and airborne routes. Two major interventions for prevention of indirect contact from fomites include hand hygiene and surface disinfection. Given the difficulty in monitoring and ensuring compliance with hand hygiene, the importance of surface disinfection has been deemed more and more critical over the past decade. Nevertheless, a major bottleneck with surface disinfection as a transmission reduction intervention is that it is a “momentary event’, and microorganisms rapidly recontaminate the environment after traditional disinfection approaches. One improvement to these surface disinfection interventions may be to add continuously acting disinfectants or antimicrobial surface coatings to compatible surfaces. These are products that have bactericidal or bacteriostatic activity for an extended period of time. Several of these products exist, but only a few have shown effectiveness in interventional studies against a variety of pathogens. Conclusion During a time when SARS-CoV-2 is ravaging the world, when influenza viruses decimate populations annually, and countless other respiratory viruses cause significant morbidity, ensuring the most effective prevention interventions are both socially accepted and evidence-based is critical. Our approaches to respiratory virus transmission reduction must be all-encompassing if we wish to truly break the chain of transmission. This includes ensuring environmental hygiene through surface disinfection.
Recognizing Social Media-Related Depression
Authors: Kamal Shaan , Malik Mohammed , Blumenshine​ Philip
Published: August 2022

Depression and anxiety in adolescents and young adults is reaching epidemic proportions. From 2005 to 2014, the overall prevalence of depression in adolescents aged 12 to 17 increased from 8.7% to 11.3% and from 2011 to 2018, rates of depression and anxiety in college students increased from 31.5% to 42.2% and 51.5% to 63.6% respectively.1,2 Psychological well-being, a closely related construct, decreased suddenly for adolescents around 2012 and has remained low since that time.3 These trends have been mirrored by a simultaneous increase since 2012 in smartphone adoption and screen-time, particularly social media usage, among American adolescents. The COVID-19 pandemic accelerated these trends: adults in April and May of 2020 were three times as likely to screen positive for depressive and anxiety disorders compared to the year prior.4 Today, social media is omnipresent in the lives of adolescents and adults. The Pew Research Center found that 84% of Americans aged 18-29 adults use at least one social media site and Piper Sandler Investment Research found that the average teen spends 12 hours per week on social media.5,6 Social media usage is a new and important consideration when dealing with and organizing efforts to combat rising depression and anxiety.
The United States Healthcare System Today: The COVID-19 Era
Authors: Ibrahim Ramzi , Ashraf Sana , Takruri Yessar
Published: August 2022

Although the COVID-19 pandemic was a surprise for many, this was anticipated by many public health officials. Organizations have long warned of the potential of a viral outbreak, however many of these organizations were eventually defunded, or ignored. As we know, COVID-19 is a highly transmissible virus with the potential for life-threatening outcomes, while also capable of dismantling economic and healthcare infrastructure. The first case of COVID-19 in the United States was confirmed on January 20, 2020, and now the US leads in the highest number of confirmed cases globally. On March 11, 2020, the World Health Organization (WHO) declared the coronavirus a pandemic (1). The initial response to COVID-19 was inefficient and consisted of strict testing requirements that severely underestimated the prevalence of the disease, setting the US back months from containing the spread. This pandemic has magnified the weakness of the current healthcare system in the US and has identified areas that are in need of improvement. In this article, we describe inefficiencies that have been brought to light by this global pandemic while comparing similar points seen in other countries outside of the United States. Greater efforts are warranted to improve the current healthcare system and to potentially prevent the spread of future outbreaks within the United States.
Social Protection During COVID-19 Crisis in India, Especially Among Vulnerable Populations
Authors: Prasad Narayana , Fernandes Edmond , Lakhotia Shrey , Coelho Delma , Prasad Sukanya
Published: August 2022

Over the last 20 years, India’s per capita income has quadrupled, and its poverty has declined at a similar rate17. Despite a significant increase in government spending on social protection, India spends under 3% of its gross domestic product (GDP) on social safety-net programs whereas OECD (Organization for Economic Co-operation and Development) and non-OECD Asian countries spend up-to 15% and 6% of their GDP on similar social protection programs respectively14. The key markers of effective social protection are an expansion of good jobs, maintaining human capital, and offering equal opportunities. Unfortunately, the health sector in India is considerably under-funded with competing priorities of infectious diseases, a growing tide of non-communicable diseases, and continued hammering of natural disasters given the vulnerability of its geographic location19. In 2015, India was among the top three disaster-hit countries, which led to economic damages worth $3.3 billion16. With a pandemic like COVID-19, these cascading risks push India’s vulnerable low and middle class into abject poverty, anxiety, and an at-risk future15.   One of the starkest stories of our era belongs to the year 2020 where the novel coronavirus has disrupted normalcy, hijacked social protection from a policy standpoint, and crippled the achievements towards 2030 agenda of sustainable development goals (SDGs). Both the disease and lockdown have caused immense human and economic costs to the country. Although it is too early to measure the extent of human cost and suffering, the economic cost is trending in a negative direction. Although the future looks hazy at best, addressing this crisis within the lens of social protection is prudent and ethical13. This may be the only viable pathway to stop India from an impending catastrophic downfall.
American Universities Prioritized Profit Over the Health of Their Students
Authors: Bosman Josh
Published: August 2022

It is no secret that the proverbial “college experience” has undergone a fundamental reshaping in the past few decades. With the advent of technologies that allow for remote learning and the substitution of long nights in the library for expedited searches on Google Scholar, the process of acquiring a postsecondary education has never been easier. Yet in spite of this easing of labor costs for universities, the average yearly price of college tuition at a public university has increased from $8,180 in 1977 to $20,770 in 2017[1]. Meanwhile, the real median personal income in the United States has only increased from $24,775 in 1977 to $33,334 in 2017 [2]. I found this pattern distressing prior to COVID-19, but now I find it downright irresponsible. In March of 2020, universities across the country put in-person services on hold. This movement implied a vested interest in public health by university administrators, and likely contributed to the prevention of thousands of deaths [3]. As noble as these decisions to shut down were, their timing bears consideration. Many universities were already largely vacant due to the scheduling of Spring Break. Tuition fees for the Spring 2020 semester had likely been paid months prior and were securely non-refundable. I wonder how an alternative series of events would have played out, in which universities had been compelled to shut down many months - instead of just eight to twelve weeks - prior to their summer recesses.
Utilizing Employer Created Social Support Programs to Assist Frontline Nurses to Cope with the Psychological Symptoms of Trauma-Induced Stress and Burnout connected to Patient Death during the COVID-19 Healthcare Crisis in the United States
Authors: A. Kaplan Mitchell , Sumrah Rohan , M. Inguanzo Marian
Published: August 2022

According to the latest epidemiological data from the National Center for Health Statistics, the total number of confirmed patient deaths at hospitals nationwide associated with COVID-19 between January 1st, 2020 and April 24th, 2021 has reached 569,771, a figure that continues to rise steadily each month, despite government efforts to vaccinate the nation's population against the disease (CDC tracker data updated, April 2021). Research shows that the effects of the COVID 19 crisis have had a devastating impact on the lives of thousands of health care workers and forced hospitals across the country to operate at maximum capacity, sometimes to the point of overload. Hospitals have given frontline staff, especially nurses, the primary responsibility for providing compassionate first-rate care to these critically ill patients in high-risk infectious disease settings. Nurses caring for patients with COVID 19 have witnessed a high volume of fatalities within a short space of time, which has resulted in severe adverse effects on their mental health. Frequent exposure to unmitigated loss of life on inpatient intensive care units and in emergency rooms nationwide triggered by the escalation of the COVID-19 pandemic is fast becoming a significant source of acute psychological and physical distress for a substantial number of nurses and other frontline service providers engaged in the battle to save the lives during this unprecedented time. A review of the results of studies cited in the nursing literature provides substantial evidence that demonstrates that nurses exposed to a high number of COVID-19 deaths daily are at increased risk for developing symptoms of psychopathology such as clinical depression, severe anxiety, and fatigue that can impair their job performance and lead to burnout (Maharaj et al., 2018, p. 61). The purpose of this article will be to examine the effectiveness of employer-created social support programs as an institutional resource to help frontline nurses deal with the psychological symptoms of trauma associated with patient death resulting from the COVID-19 healthcare crisis.
Additions to the flora of Lucknow district, Uttar Pradesh
Authors: Baleshwar  , Datt Bhaskar
Published: August 2022

The present study reveals the occurrence of Aristolochia bracteolata Lam. and Ipomoea coptica (L) Roem. & Schult. from Lucknow district as new additions to the flora of Lucknow district.
Fort flora of Gulbarga and Bidar, Karnataka
Authors: Shrishail C. , Mathad Pratima
Published: August 2022

A survey of Flora of Gulbarga and Bidar Fort, Karnataka was carried out during the year May-2007 to April-2008. During this survey identified 221 species of plants belonging to 63 families, which consist of Algae 20 species, Lichens 2 species, Bryophytes 08 species, Pteridophytes 08 species, Gymnosperms 06 species, Angiosperms including Monocotyledons 27 species, 23 Genara, 04 family, and Dicotyledons 150 species, 121 Genera, 46 Families, were recorded. Three species i.e Hyptis suaveolens, Lantana camara, and parthenium hysterophorus, were found as invasive weed species.
An update on grass flora of Uttarakhand (Excluding Bambuseae)
Authors: Kandwal Manish , Gupta B.
Published: August 2022

129 genera and 475 species of grasses have been listed from Uttarakhand on the basis of literature and specimens preserved in DD, BSD, LWG, BSA, Cal besides Herbaria of D.A.V. College, Dehra Dun, GUH, Srinagar, Garhwal, KUH, Nainital, GBPHRI, Almora, CDRI and CIMAP, Lucknow.
An addition to the fern flora of Pauri Garhwal, Uttarakhand
Authors: Pande H. , Kumar Brijesh
Published: August 2022

The present paper deals with 27 species, which are additions to the fern flora of Pauri district of Uttarakhand state. Each species in provided with correct botanical name and the basionym (if any). Nomenclature has been made up to date.
Caudalejeunea lehmanniana (Gottsche) A. Evans (Hepaticae: Lejeuneaceae) – A new record for Indian Bryoflora from Lohit district, Arunachal Pradesh
Authors: Dey Monalisa , Singh Devendra
Published: August 2022

Caudalejeunea lehmanniana (Gottsche) A. Evans, earlier known from China, Africa, North and South America, has been described and illustrated for the first time in Indian bryoflora from Madhuban (Namsai) in Lohit district of Arunachal Pradesh. A key to the Indian species of genus Caudalejeunea (Steph.) Schiffn. has been provided.
Pengaruh Thriving At Work dan Komitmen Afektif terhadap Kinerja Karyawan Organisasi Publik Kantor Desa Cibenda, Kecamatan Cipongkor, Kabupaten Bandung Barat
Authors: Barokah Rezky Afiahtul , Amin Dede Saeful , Supriatna Iwan , Rahman Najla Luqyana , Ridwansyah Febrian
Published: August 2022

Penelitian ini bertujuan untuk menganalisis dan mengidentifikasi pengaruh thriving at work dan komitmen afektif terhadap kinerja karyawan kantor Desa Cibenda, Kecamatan Cipongkor, Kabupaten Bandung Barat. Penelitian ini dilakukan dengan metode kuantitatif melalui survei dan pendistribusian kuesioner kepada 60 karyawan kantor Desa Cibenda. Kuesioner diukur menggunakan skala Likert. Data yang diperoleh diolah menggunakan analisis regresi linear berganda dengan software SPSS 25. Temuan penelitian ini menunjukkan bahwa thriving at work dan komitmen afektif telah dimiliki dan dipraktikkan oleh karyawan. Selanjutnya, peneliti juga menemukan bahwa thriving at work dan komitmen afektif sama-sama memiliki pengaruh signifikan terhadap kinerja karyawan, dan hal ini membantu mereka dalam melayani masyarakat. Hasil penelitian ini dapat menjadi pertimbangan atasan atau pimpinan di Kantor Desa Cibenda ataupun organisasi publik lainnya, untuk memperhatikan thriving at work karyawan dan komitmen afektif mereka, sehingga dapat meningkatkan kinerja.
The Evolving Russo-Pak Entente-Cordiale: Challenges for the Future
Authors: Begum Toheeda
Published: August 2022

Historically, the Russo-Pak relationship had aforeign policy context and a legacy that went through the historic eras of pre-partition Great Game between the British Indian and Czarist Empires,and the post-partition Cold War between the former Union of Soviet Socialist Republics (USSR) and the United States of America (USA).Pakistan on its creation sided with the American led West through Southeast Asia Treaty Organization (SEATO) and Central Treaty Organization (CENTO) or Baghdad Pact, plus, the partnerships against the Soviet occupation of Afghanistan and in the War on Terror. The US military and financial aid and the support by the International and Asian financial institutions for Pakistan is decades old—albeit now with a friction over Afghanistan, Russia and China. Still, the transactional-cooperation remains over Afghanistan through the air-corridorthatis useful for Americans in many ways. American influence, assets and the air-corridor is a deadly mix in Afghanistan. The Afghan Taliban know thatthe drones, jets and aircrafts using the corridor take-off from and land at Qatar without ever landing in Afghanistan. Moreover, intelligence sharing is part of Pak-US operational cooperation with a possibility of a military base too. The context of Pak-US cooperation is the centuries old British era Frontier Policy. It remained until the American strategic withdrawal from Afghanistan. Therelationship since then has deteriorated and the perception of each other is not harmonious despite the tactical cooperation in Afghanistan. The reason is the strategic choices made by Pakistan and America lackingcongruence over China, Russia, Afghanistan and India.Theinteractive-arm-twisting of Pakistan is an indicator. The restis the detail of Pakistan’s New Frontier Policy.
Temporomandibular Eklem Bozukluklarında Güncel Tedavi Yaklaşımları
Authors: YÜCELER Özgecan , ÖZTÜRK Öykü , UĞAR ÇANKAL Dilek Aynur
Published: August 2022

Temporomandibular eklem bozuklukları; çiğneme kaslarının, temporomandibular eklem ve temporomandibular ekleme komşu dokuların çoğunlukla ağrılı, fizyolojik ve fonksiyonel bozuklukları olarak tanımlanmaktadır. Günümüzde diş hekimliğinde hala önemli bir sorun olan temporomandibular eklem bozukluklarına iyatrojenik faktörler, okluzyon bozukluğu, travma, emosyonel değişimler gibi birçok faktör sebep olabilmektedir. Tedavisinde etken olan etiyolojik ve patolojik faktörlerin düzeltilmesi, hastalık semptomlarının giderilmesi, eklem mobilitesinin yeniden sağlanması ve postural iyileşme amaçlanmaktadır. Bu amaçla tedavide hasta eğitimleri, farmakolojik ajanların kullanımı, psikolojik tedavi uygulamaları, fiziksel tedavi, manuel tedavi, okluzal splintlerin kullanımı ve cerrahi tedavi yaklaşımları tek tek veya kombine halde uygulanabilmektedir.
Therapeutic use of Mesenchymal Stem Cells against SARS-Cov-2: Present and Future prospects
Authors: Jaiswal Akriti , Jaiswal Dhirendra , Jain Ravindra Kumar , Manglic Shivani , . Sakshi , Pandey Ishan , Singh Pooja , Kant Surya , Shukla Vikas , Mavi Anil Kumar
Published: August 2022

The Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) outbreak, also known as COVID-19, from the seafood market in Wuhan, China, has the world on its knees within a short time, impacting health infrastructure, economy, science, and most importantly human existence. On March 11, 2020, the World Health Organization (WHO) declared COVID-19 a pandemic. Since the first encounter with COVID-19, the medical fraternity has been exploring various ways to counter the disease and related complications. Attempts have also been made to prevent infection by developing vaccines to reduce the severity of the disease and mortality postinfection. However, even as the first peak of the epidemic (also known as the “first wave”) has flattened, the second peak (second wave) has been even more detrimental, with a rapid rise leading to an unprecedented burden on healthcare infrastructure and resulting in high mortality. The second wave has been predicted to be triggered by a double mutant strain, which resulted in a higher incidence of pneumonia, faster progression of the disease, increased oxygen requirements, and higher mortality. In contrast to the current treatment options available, which include antivirals, antimalarial, and anti-inflammatory agents, MSC can be proved to be a better treatment modality for COVID-19. In this article, we focus on the role and use of mesenchymal stem cells (MSC) as a potential therapeutic measure to win the battle against the SARS-CoV-2 virus.
Sintesis Adsorben dari Kulit Kolang-Kaling (Arenga pinnata) pada Limbah
Authors: Laksono Elfandra Pramudita , Sunardi Sunardi , Oktavianty Herawati
Published: August 2022

Telah dilakukan penelitian tentang pembuatan arang aktif dari kulit kolang-kaling (Arenga pinnata). Penelitian ini bertujuan untuk menghasilkan arang aktif dari kulit kolang-kaling yang akan digunakan sebagai adsorben pada limbah buatan. Penelitian ini menggunakan rancangan percobaan blok lengkap dengan dua faktor yaitu rasio berat arang aktif dan jumlah pelarut H3PO4 (1:1%w/v; 1:1.5%w/v; 1:2%w/v), dan variasi konsentrasi pelarut H3PO4 (20%; 40%; 60%). Analisis BET dilakukan pada adsorben untuk mengetahui luas permukaan adsorben serta dilakukan analisis kadar abu pada arang aktif yang dihasilkan. Adsorben sebanyak 1 gr dimasukkan ke dalam 100 ml limbah buatan yang mengandung ion logam Pb dan Mn. Kemudian diaduk dan didiamkan selama 3 jam, kemudian dilakukan analisis logam ion Pb dan Mn. Hasil penelitian menunjukkan bahwa adsorpsi ion logam Pb dan Mn masing-masing adalah 92,95% dan 22,63% dihasilkan. Hal ini menunjukkan bahwa aktivasi asam yang digunakan pada karbon aktif dapat meningkatkan luas permukaan adsorben yang dihasilkan sehingga mampu mengadsorbsi pengotor dengan baik. Luas permukaan adsorben yang digunakan yang menghasilkan adsorpsi terbaik adalah 11,272 m2/g, dengan kadar abu sebesar 7,891%.
Selai Albedo Kulit Semangka dengan Penambahan Umbi Bit
Authors: Sitorus Mauliza Safira Asnim , Partha Ida Bagus Banyuro , Setya Erista Adi
Published: August 2022

Penelitian ini tentang selai albedo kulit semangka dengan penambahan umbi bit yang bertujuan untuk mengetahui pengaruh penambahan umbi bit terhadap karakteristik selai dan pengaruh perbandingan kulit buah semangka dan umbi bit terhadap sifat kimia dan sifat fisik pada selai yang dihasilkan.
            Rancangan penelitian yang digunakan dalam penelitian adalah rancangan blok lengkap dua faktor yaitu variasi perbandingan albedo kulit semangka dengam umbi bit dan penambahan konsentrasi gula. Faktor A yaitu variasi perbandingan albedo kulit semangka dengan umbi bit terdiri dari 3 taraf yaitu A1 = 30:70 b/b, A2 = 50:50 b/b, A3 = 70:30 b/b dan faktor B yaitu penambahan konsentrasi gula terdiri dari 3 taraf yaitu B1 = 60%, B2 = 65%, B3 = 70%. Analisis yang dilakukan yaitu Aktivitas Antioksidan, Gula Reduksi, Gula Total, Kadar Air, Total Padatan, Daya Oles, Viskositas dan Uji Organoleptik (Warna, Aroma, Rasa, Daya Oles).
   Hasil penelitian ini menunjukkan bahwa variasi albedo kulit semangka dengan penambahan umbi bit berpengaruh nyata terhadap aktivitas antioksidan, gula reduksi, viskositas dan uji organoleptik (warna, aroma, daya oles) tetapi tidak berpengaruh nyata terhadap gula total, kadar air, total padatan terlarut, daya oles, dan uji organoleptik (rasa), sedangkan penambahan konsentrasi gula berpengaruh nyata terhadap aktivitas antioksidan dan uji organoleptik (rasa, warna, daya oles), tetapi tidak berpengaruh nyata terhadap daya oles, viskositas, gula reduksi, gula total, total padatan terlarut, kadar air, dan uji organoleptik (rasa, warna, daya oles). Berdasarkan uji kesukaan organoleptik perlakuan yang paling disukain panelis yaitu perbandingan albedo kulit semangka yang lebih tinggi dari pada penambahan umbi bit (70:30)  dengan penambaahan konsentrasi gula sebesar 65%.
Formulasi The Rempah dengan Penambahan Pewarna Alami
Authors: Prabowo Muhammad Farros , Bimantio Mohammad Prasanto , Widyowanti Reni Astuti
Published: August 2022

Penelitian ini bertujuan untuk menganalisa pengaruh formula rempah dan pewarna alami terhadap sifat-sifat fisik dan kimia teh rempah yang dihasilkan, serta menemukan dan menganalisa formulasi yang paling disukai dan memiliki aktivitas antioksidan yang paling tinggi. Rancangan penelitian ini menggunakan metode rancangan blok lengkap yang terdiri dari dua faktor. Faktor A merupakan komposisi dari bahan rempah (95% dari 1,9 gram berat total) yang terdiri dari empat taraf yaitu A1 (jahe 10%, pala 20%, kayu manis 20%, cengkeh 5%, sereh 15%, kapulaga 25%),  A2 (jahe 15%, pala 10%, kayu manis 25%, cengkeh 10%, sereh 20%, kapulaga 15%),  A3 (jahe 20%, pala 10%, kayu manis 15%, cengkeh 15%, sereh 25%, kapulaga 10%), A4 (jahe 15%, pala 10%, kayu manis 20%, cengkeh 25%, sereh 20%, kapulaga 5%) dan faktor B merupakan jenis pewarna alami (5% dari 0,1 gram berat total) yang terdiri dari atas tiga taraf.yaitu B1 (bunga rosella 5%), B2 (umbi bit 5%), B3  (bunga telang 5%). Untuk menentukan kualitas teh rempah, maka dilakukan uji sifat kimia (aktivitas antioksidan, kadar air, dan kadar abu), uji fisik (uji warna Munsell), dan uji organoleptik (kesukaan warna, rasa, dan aroma).
Hasil penelitian ini diketahui bahwa formulasi bahan rempah dan penambahan pewarna alami berpengaruh nyata terhadap kandungan aktivitas antioksidan, kadar air, dan uji kesukaan organoleptik tetapi tidak berpengaruh nyata terhadap kadar abu dan uji warna Munsell sehingga dapat dikatakan bahwa terdapat interaksi antara formulasi rempah dengan penambahan warna alami terhadap uji aktivitas antioksidan dan uji kesukaan organoleptik. Hasil penelitan lainnya juga diketahui bahwa terdapat interaksi terhadap uji aktivitas antioksidan dan uji organoleptik (kesukaan warna, rasa, dan aroma). Skor kesukaan organoleptik terbesar yaitu 6,37 (suka) yang terdapat pada sampel A3B1 yang terdiri dari jahe 20%, pala 10%, kayu manis 15%, cengkeh 15%, sereh 25%, kapulaga 10%, dan bunga rosella sebanyak 5%. Sampel A3B1 memiliki aktivitas antioksidan 58,5946%, kadar air 20,8691%, kadar abu 2,4266%, dan uji warna Munsell 84,5. Adapun rerata kadar air secara keseluruhan 22,7655% (tidak memenuhi SNI) dan rerata kadar abu keseluruhan 2,6520 % (memenuhi SNI).
PENDUGAAN UMUR SIMPAN FOOD BAR TALAS BENENG METODE ACCELERATED SHELF-LIFE TESTING (ASLT) MODEL ARRHENIUS DENGAN KEMASAN ALUMUNIUM FOIL
Authors: Nirwana Nanda Kuntum , Eris Fitria Riany , Riyanto Rifqi Ahmad , Putri Nia Ariani
Published: August 2022

Food bar merupakan jenis makanan semi basah dengan kandungan kalori dan protein tinggi yang diformulasikan secara khusus dari berbagai macam bahan dengan bentuk batang dan dikonsumsi pada saat sela-sela waktu makan. Inovasi pengembangan produk food bar dapat dilakukan dengan substitusi atau penambahan bahan pangan lain yang layak dikonsumsi, salah satunya yaitu tepung talas beneng. Informasi umur simpan produk diperlukan untuk menjamin bahwa produk masih layak dikonsumsi dan belum mengalami kerusakan. Penelitian ini bertujuan untuk mengetahui pendugaan umur simpan food bar talas beneng menggunakan metode Accelerated Shelf Life Testing (ASLT) dengan persamaan Arrhenius. Pengujian pendugaan umur simpan dengan metode ASLT model Arrhenius dilakukan pada tiga suhu penyimpanan mewakili suhu dingin, ruang dan panas yaitu 5, 25 dan 45 ⁰C selama 28 hari dengan waktu pengamatan setiap 7 hari. Adapun parameter yang diamati yaitu kadar air. Berdasarkan hasil yang diperoleh, diketahui bahwa food bar talas beneng yang dikemas dengan aluminium foil memiliki umur simpan yang berbeda pada setiap suhu penyimpanan. Adapun umur simpan food bar talas beneng pada penyimpanan suhu 5⁰C, 25⁰C dan 45⁰C secara berurut yaitu 8,95 hari, 9,56 hari dan 7,24 hari.

 

Kata Kunci : ASLT, food bar talas beneng, umur simpan
Design and Analysis of Cloud Data's Multi-Layer Security Protection
Authors: Byali Ramesh , Jyothi Ms. , Shekadar Megha Chidambar
Published: August 2022

To store and access sensitive information from distant locations utilizing an internet connection, cloud servers are now often employed. By adopting cloud servers as their primary source of data storage, almost all businesses and organizations made the transition from local to distant data storage. It has become a struggle for each and every person to give additional security for the cloud data because, in general, cloud servers do not have total protection for the data that is stored on them. Data is a useful resource that can take many different forms, including payment information, personal information, bank account information, and many others. Due to the absence of data security in all of these forms, we try to useSome cutting-edge encryption methods for protecting the data that is kept in remote locations. Two parties make sure that a third party cannot access their communication when they communicate through a medium. It is better to use encryption methods to encrypt data in a cipher, send it over the internet, and then decrypt it to reveal the original data. By transforming plaintext into cipher text, the science of cryptography encrypts and decrypts data to keep messages private. In this project, we primarily develop 3 techniques, including: The three strategies are columnar transposition, rail fence transposition, and caesar substitution. Data can be protected and returned to its original state using all three processes together.
Influence of Pandemic (Covid-19) on Teachers & Students during Online Education- A Study
Authors: Agarwal Dr. Ashima , Agrawal Aarush , Agrawal Dr. Sunil
Published: August 2022

Covid-19 has forced schools, colleges and universities in India and around the world to suspend physical classrooms in favor of online classes. While most private/public schools/colleges/universities in India have made the transition smoothly, a few are still adjusting. There have also been discussions about the nature of classes and the future of examination and evaluation, including whether or not they could be conducted online. While faculty grapples with new ways to manage this abrupt shift to online education, students cling to their mobile phones and computer screens. How would higher education be affected if the lockdowns continued for an extended period of time? What are some of the more serious issues that necessitated introspection? And what does this mean for the students going first response: Going digital
Students’ Difficulties in Acquiring English Writing
Authors: Dwi Putri Ade Lestari , Tambusai Azhary , Hasibuan Ahmad Laut
Published: August 2022

Writing skill is an essential skill which includes all knowledge and abilities to express one’s ideas through the written word. However, English writing has always been a challenge to master by the students, especially students in junior high schools. The main objective of this research is focused on finding out student’s difficulties in acquiring writing English. This study used case study with descriptive qualitative research. About 26 students are as the participants of the research. The data gained through document analysis, questioners and interview. The result indicates students had a significant problem in writing English. The findings revealed that the most significant problems are because of their lack of vocabulary mastery and language used. They assumed that they had limited knowledge in constructing sentence grammatically and also their lack of vocabulary mastery made them felt confused in choosing the word. Besides, they also were not interested in English.
Efektivitas Model Pembelajaran Problem Posing Terhadap Kemampuan Berpikir Kritis Matematis siswa kelas VII SMP Negeri 9 Buton Tengah
Authors: Herlawan Herlawan
Published: August 2022

Tujuan dalam penelitian ini adalah untuk mengetahui efektivitas model pembelajaran Problem Posing terhadap kemampuan berpikir kritis siswa kelas VII SMP Negeri 9 Buton Tengah. Penelitian ini merupakan penelitian kuantitatif dengan metode eksperimen dan desain penelitian Posttest-Only Control. Populasi dalam penelitian ini adalah seluruh siswa kelas VII SMP Negeri 9 Buton Tengah yang terdiri dari dua kelas dengan jumlah keseluruhan 44 siswa. Sampel dalam penelitian ini yaitu kelas sebagai kelas eksperimen dengan jumlah 21 siswa dan kelas sebagai kelas kontrol dengan jumlah 23 siswa. Instrumen yang digunakan dalam penelitian ini adalah essay tes sebanyak 5 nomor. Hasil penelitian yang diperoleh: 1) rata-rata kemampuan berpikir kritis siswa kelas eksperimen sebesar 81,90; 2) rata-rata kemampuan berpikir kritis siswa kelas kontrol sebesar 71,74; 3) berdasarkan hasil uji hipotesis dengan menggunakan uji t diperoleh nilai signifikan 0,003 < 0,05. Dengan demikian ditolak dan diterima. Sehingga dapat disimpulkan bahwa model pembelajaran Problem Posing efektif digunakan untuk meningkatkan kemampuan berpikir kritis siswa kelas VII SMP Negeri 9 Buton Tengah.
Pengaruh Penguasaan Bilangan Bulat Terhadap Penguasaan Konsep Aljabar pada Siswa Kelas VII SMP Negeri 1 Siompu
Authors: Armin Rismayani , Idham Nurhasmi
Published: August 2022

Penelitian ini bertujuan 1). Untuk Mengetahui tingkat penguasaan bilangan bulat terhadap penguasaan konsep aljabar pada siswa kelas VII di SMP Negeri 1 Siompu, 2). Untuk mengetahui ada tidaknya pengaruh yang signifikan antara penguasaan bilangan bulat terhadap kemampuan menyelesaikan perhitungan konsep aljabar pada siswa kelas VII SMP Negeri 1 Siompu. Penelitian ini adalah penelitian exspost facto. Populasi dalam penelitian ini adalah kelas VII SMP Negeri 1 Siompu yang terdiri dari 2 kelas. Sampel dalam penelitian ini adalah siswa kelas VIIA sebagai kelas eksperimen dan siswa kelas VIIB sebagai kelas kontrol yang masing-masing berjumlah 23 siswa untuk setiap kelas. Instrumen yang digunakan dalam penelitian ini berupa tes hasil belajar. Berdasarkan hasil analisis deskriptif yang berkaitan dengan penguasaan bilangan bulat menunjukan bahwa tingkat penguasaan rendah sebanyak 8 orang atau 17,4 %, tingkat penguasaan sedang sebanyak 31 orang atau 67,4 %, dan tingkat penguasaan tinggi sebanyak 7 orang atau 15,2 %. Sedangkan hasil analisis deskriptif yang berkaitan dengan penguasaan konsep aljabar menunjukan bahwa tingkat penguasaan rendah sebanyak 5 orang atau 10,9 %, tingkat penguasaan sedang sebanyak 29 orang atau 63 %, dan tingkat penguasaan tinggi sebanyak 12 orang atau 26,1 %. nilai rata-rata penguasaan bilangan bulat sebesar 64,45 sedangkan penguasaan konsep aljabar sebesar 7,85. Hasil uji hipotesis diketahui  dan signifikan pada  dengan demikian H0 ditolak H1 diterima. Hal ini berarti ada pengaruh penguasaan bilangan bulat terhadap penguasaan konsep aljabar pada siswa kelas VII SMP Negeri 1 Siompu.
Pengaruh Pembelajaran dengan Teknik Scaffolding Terhadap Kemampuan Representasi Matematis Siswa SMP Negeri 4 Baubau
Authors: Rasmuin Rasmuin , Ningsi Trisna Agus
Published: August 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh pembelajaran dengan teknik scaffolding terhadap kemampuan representasi matematis siswa SMP Negeri 4 Baubau. Penelitian ini adalah penelitian kuantitatif dengan menggunakan eksperimen dengan desain posttest-only control group desain. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 4 Baubau tahun ajaran 2019/2020 dan terdiri dari 14 kelas. Sampel dalam penelitian ini diambil menggunakan sample random sampling yaitu siswa kelas VIII.6 dan siswa kelas VIII.4 yang berjumlah 31 siswa untuk setiap kelas. Instrumen yang digunakan dalam penelitian ini berupa essay tes kemampuan representasi matematis siswa. Data yang diperoleh dianalisis dengan menggunakan analisis deskriptif dan analisis inferensial dalam bentuk uji-t. Hasil penelitian yang diperoleh adalah: 1) hasil tes untuk kelas eksperimen diperoleh nilai rata-rata yaitu 83,87; 2) hasil tes untuk kelas kontrol diperoleh nilai rata-rata yaitu 63,7; 3) dari hasil uji hipotesis dengan menggunakan uji t diperoleh thitung = 7,756 dan diperoleh nilai signifikansi 0,000 < 0,050 sehingga disimpulan H0 ditolak. Dengan demikian penerapan pembelajaran dengan menggunakan teknik scaffolding berpengaruh sevara signifikan terhadap kemampuan representasi matematis siswa SMP Negeri 4 Baubau.
Meningkatkan Hasil Belajar Siswa Melalui Penggunaan Mistar Hitung pada Operasi Bilangan Bulat
Authors: Rahmatia Rahmatia , Armin Rismayani
Published: August 2022

Rumusan masalah dalam penelitian adalah apakah penggunaan mistar hitung dapat meningkatkan hasil belajar siswa kelas IV SD Negeri 5 Mawasangka pada operasi bilangan bulat?. Tujuan penelitian  ini  adalah untuk meningkatkan prestasi belajar siswa kelas IV SD Negeri 5 Mawasangka pada operasi bilangan bulat dengan menggunakan mistarhitung. Jenis penelitian ini adalah penelitian tindakan kelas yang terdiri dari 2 siklusdengan prosedur penelitian yaitu: (1) Perencanaan, (2) Pelaksanaan Tindakan, (3) Observasi dan Evaluasi, (4) Refleksi. Subjek dalam penelitian adalah siswa kelas IV SDN 5 Mawasangka yang berjumlah 21 orang. Instrumen penelitian ini adalah Lembar observasi, dan Tes hasil belajar dengan teknik pemngambilan data yaitu observasi lalu kemudian pemberian tes. Teknik analisis data hasil penelitian yaitu reduksi data, menyajikan data serta menarik kesimpulan dari data tersebut. Berdasarkan hasil observasi dan tes, pada siklus Iterlihat siswa yang memperoleh nilai < 60 adalah sebanyak 8 orang ketuntasan belajar secara klasikal mencapai 61,9% sedangkan pada hasil tes siklus II nilai siswa juga meningkat, semua siswa sudah memperoleh nilai ≥ 60 dengan rata-rata 82,74 dan ketuntasan belajar secara klasikal mencapai 100%, maka dapat disimpulkan bahwa dengan menggunakan mistar hitung dapat meningkatkan hasil belajar siswa kelas IV SD Negeri 5 Mawasangka pada materi bilangan bulat.