bluuebunny/crossref_metadata_2025 huggingface dataset:
Significant response from fruquintinib plus anti-PD-1 immunotherapy for microsatellite stable metastatic colorectal cancer with liver and lung metastasis in the third line: A case report
Authors: He Lina , Cheng Xiaojiao , Zhou Cong , Li Qingli , Zhang Baiwen , Cheng Xin , Tu Shuiping
Published: July 2023

Background: The treatment in patients with metastatic colorectal cancer (mCRC) has limited options. About 90% of CRC patients with mismatch repair proficient/microsatellite stable (pMMR/MSS) tumors, were almost unresponsive to PD-1 antibody treatment. This report shows that a patient with pMMR/MSS mCRC achieved significant response from tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor (VEGFR) family (VEGFR-1,2,3) (fruquintinib) plus anti-PD-1 immunotherapy in the third line, providing a reference for the treatment of some MSS mCRC patients.
Case presentation: This case described a 65-year-old male with CRC who was diagnosed with pT4aN2bM0, IIIC and pMMR/MSS after curative surgery in August, 2018. Subsequently, he received adjuvant chemotherapy(FOLFOX for 5 cycles), first-line treatment(pelvic radiation plus capecitabine) and second-line treatment(TOMIRIplus cetuximab for 2 cycles), but lung, liver, and pelvic cavity metastases worsened in October 2019. Thus, he began receiving the fruquintinib plus PD-1 inhibitor(FP) regimen as third-line treatment and after three cycles, the size of the lung lesions was significantly reduced and evaluated as partial response(PR), while the liver and pelvic cavity lesions remained stable. As of December 2021, he had received a total of 33 courses of FP regimen. On February 17, 2022, the liver lesions were progressed. In brief, he achieved a long progression-free survival(PFS) of 28 months and overall survival(OS) of 40 months from the third-line treatment. Additionally, the patient tolerated the combined treatment.
Conclusions: Fruquintinib combined with immunotherapy exerted good therapeutic effects with safety, and may bring more clinical benefits to MSS mCRC patients, especially with lung metastasis.
P4HA2 promotes proliferaton, invasion and metastasis through the regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma
Authors: Chi Zengpeng , Wang Qimin , Tong Lei , Li Dagang , Qiu Jing , Yang Fang , Guo Qingyuan , Zheng Jiawei , Chen Zhenggang
Published: July 2023

Proline 4-hydroxylase 2 (P4HA2) has been reported as a protein with hydroxylase activity that mainly plays a role in hydroxylation of collagen precursors and promoting collagen cross-linking under physiological conditions; its overexpression has been confirmed to exert a certain influence on a wide variety of malignant tumors’ occurrence and development. whereas its effects and possible mechanism in OSCC are unclear. In this study, a focus was placed on the investigation of the expression pattern, functions of carcinogenesis, and underlying mechanisms of P4HA2 in OSCC cells. The TCGA, UALCAN, GEPIA and K-M plotter databases and paraffin samples were employed to identify the P4HA2 expression in cancer and its relationship with clinicopathological features. Subsequently, P4HA2 knockdown and overexpression cell models were built, with the aim of assessing its oncogenic roles and mechanisms. Thus, as indicated by the result, P4HA2 was subjected to overexpression in OSCC and showed an inverse correlation with patient survival. P4HA2 knockdown suppressed OSCC cells’ invasion, migration and proliferation in vitro and vivo, while P4HA2 overexpression exerted the opposite effect. Mechanistically, expressions of phosphorylated PI3K/AKT pathway were restrained after P4HA2 silencing. As revealed by the result of this study, P4HA2 serves as a promising biomarker for predicting prognosis in OSCC, thus exerting a certain effect on OSCC cells’ metastasis, invasion and proliferation on the basis of the PI3K/AKT signaling pathway regulation in the downstream.
Effect of extended home care on nursing compliance and quality of life in children with nephrotic syndrome
Authors: Wang Ying , Liu Fang , Ni Danhong , Liu Jingjing
Published: July 2023

Background: Nephrotic syndrome is characterized by a prolonged course, easy recurrence, multiple comorbidities and difficult care. Children with nephrotic syndrome have good compliance during hospitalization due to medical supervision, but often fail to implement care plans well after discharge.
Objective: To investigate the effect of continuous home care on nursing compliance, immune function and quality of life of children with nephrotic syndrome.
Methods: Ninety-eight cases of discharged children with nephrotic syndrome admitted to our hospital from January 2020 to January 2023 were selected for retrospective analysis. The children were divided into 54 cases in the observation group and 54 cases in the comparison group according to the different nursing programs. The observation group used the continuous home care model for the assessment of nursing problems, care and effect evaluation, while the comparison group used the conventional pre-discharge health education and regular telephone follow-up after discharge. The children in both groups were compared in terms of nursing care compliance, immune function and quality of life.
Results: The compliance rate of diet, fluid intake, medication, dialysis regimen, daily life, and exercise was higher in the observation group than in the control group, and the difference was statistically significant (P<0.05). The observation group had higher disease cognitive ability, disease-related behaviors, beliefs about the disease and overall scores than the control group after care, and the difference was statistically significant (P<0.05). The quality-of-life index scores of children in both groups were higher than those before care, and the scores of behavioral ability, physical function, psychological function and social function of children in the observation group were higher than those in the control group after care, and the difference was statistically significant (P<0.05).
Conclusion: Continuing home care for children with nephrotic syndrome can effectively improve the satisfaction level of children's quality of life, especially in family life, self-awareness and compliance with care.
Host susceptibility and fungal virulence in the wheat-Parastagonospora nodorum interactions
Authors: Choupannejad Roya , Sharifnabi Bahram , Collemare Jérôme , Massah Amir , Gholami Javad , Mehrabi Rahim
Published: July 2023

The fungus Parastagonospora nodorum is responsible for substantial economic losses of wheat worldwide. P. nodorum secretes multiple proteinaceous host-specific toxins known as necrotrophic effectors (NE) that induce compatible interactions with hosts possessing the corresponding dominant susceptibility (S) genes. In this study, the reaction of 40 wheat genotypes including 19 Iranian cultivars, 16 world cultivars and five differential genotypes against 33 P. nodorum isolates was investigated. In addition, the occurrence of known NEs and their corresponding S genes was assessed. Wheat genotypes were classified into six groups based on their variable reaction towards P. nodorum isolates. The S gene Tsn1 was present in 70% of highly susceptible cultivars and was completely absent in all resistant cultivars. The cultivars possessing all three S genes Tsn1, Snn1 and Snn3 were susceptible to all P. nodorum isolates. S gene Snn3 was detected in all Iranian wheat cultivars whereas the proportion of this gene in world cultivars was 62.5%. SnTox1-Snn1 was the most abundant NE-S gene frequency (100%) in Iranian P. nodorum isolates and Iranian cultivars. Furthermore, SnToxA was produced in Pichia pastoris and infiltration of SnToxA resulted in necrosis response exclusively on wheat cultivars harboring the Tsn1 sensitivity gene indicating that toxin infiltration can be used as a quick and accurate assay in breeding programs. Overall, these findings extended our substantial knowledge about P. nodorum-wheat interactions and their underlying molecular basis in Iran, a country located in the Fertile Crescent where both wheat and its pathogens coevolved.
Development and Interpretation of a Novel Nomogram for the Prognosis of Adult Metastatic Adrenocortical Carcinoma: A Retrospective Cohort Study
Authors: Huang Yi , Xie Weibin , zou Yitong , Hu Jintao , Liao Chengxiao , Yao Yuhui , Gan Qinghua , Kong Jianqiu , Fan Xinxiang
Published: July 2023

Purpose
To predict the prognosis of patients with metastatic adrenocortical carcinoma (mACC) and improve overall survival, we developed and validated a nomogram for predicting survival outcomes.
Methods
Adult metastatic patients were selected between 2000 and 2019 from Surveillance, Epidemiology, and End Results Program (SEER). Independent risk factors were identified by univariate and multivariate cox regression analysis. Overall survival was calculated by Kaplan–Meier. C-index, the area under the receiver operating characteristics curve (AUC) and calibration curve were employed to validate the model.
Results
A total of 336 mACC patients were included and randomly divided into training cohort (N = 235) and validation cohort (N = 101). The nomogram, based on independent chemotherapy and surgery predictors, exhibited favorable discrimination with C-index values of 0.704 and 0.702 for the training and validation cohorts, respectively. The AUC and calibration curve indicated favorable performance in both cohorts.
Conclusion
We constructed and validated a novel prognostic nomogram for mACC patients by incorporating chemotherapy and surgery, which assist clinical doctors to choose optimal clinical decision and improve the overall survival of mACC patients. In the future, chemotherapy combined with surgery or other may be recommended as first-line therapy for mACC patients.
The clinical value of preoperative 3D planning and 3D surgical guides for Imhäuser osteotomy in Slipped Capital Femoral Epipysis: a retrospective study
Authors: lagerburg vera , BOORN Michelle DEN , VORRINK Sigrid , AMAJJAR Ihsane , Witbreuk Melinda
Published: July 2023

Background Accurate repositioning of the femoral head in patients with Slipped Capital Femoral Epiphysis (SCFE) undergoing Imhäuser osteotomy is very challenging. The objective of this study is to determine if preoperative 3D planning and a 3D-printed surgical guide improve the accuracy of the placement of the femoral head.Methods This retrospective study compared outcome parameters of patients who underwent a classic Imhäuser osteotomy from 2009 to 2013 with those who underwent an Imhäuser osteotomy using 3D preoperative planning and 3D-printed surgical guides from 2014 to 2021. The primary endpoint was improvement in Range of Motion (ROM) of the hip. Secondary outcomes were radiographic improvement (Southwick angle), patient-reported clinical outcomes regarding hip and psychosocial complaints assessed with two questionnaires and duration of surgery.Results In the 14 patients of the 3D group radiographic improvement was slightly greater and duration of surgery was slightly shorter than in the 7 patients of the classis Imhäuser group. No difference was found in the ROM, and patient reported clinical outcomes were slightly less favourable.Conclusions Surprisingly we didn’t find a significant difference between the two groups. Further research on the use of 3D planning an 3D-printed surgical guides is needed.Trial registration Approval for this study was obtained of the local ethics committees of both hospitals.
Improvement of response bandwidth of Rydberg Receiver using an atomic array
Authors: Hu Jinlian , Jiao Yuechun , He Yunhui , Chen Teyan , Yu Xiongbin , Zhang Hao , Zhang Linjie , Zhao Jianming , Jia Suotang
Published: July 2023

We investigate the response bandwidth of a superheterodyne Rydberg receiver at a room-temperature vapor cell, and present an architecture of atomic array to increase the response bandwidth. Two microwave fields, denoted as a local oscillator (LO) ELO and a signal field ESig, couple two Rydberg states transition of |52D5/2⟩ → |53P3/2⟩. In the presence of the LO field, the frequency difference between two fields can be read out as an intermediate frequency (IF) signal using Rydberg electromagnetically induced transparency (EIT) spectroscopy. The bandwidth of the Rydberg receiver is obtained by measuring the output power of IF signal versus the frequency difference between two fields. The bandwidth dependence on the Rabi frequency of excitation lasers is presented, which shows the bandwidth decrease with the Rabi frequency of probe laser, while it is quadratic dependence on the Rabi frequency of coupling laser. Meanwhile, we investigate the effect of probe laser waist on the bandwidth, showing that the bandwidth is inversely proportional to the laser waist. We achieve a maximum response bandwidth of the receiver about 6.8~MHz. Finally, we design an architecture of atomic array for increasing the response and keeping the sensitivity, simultaneously. Our work has the potential to extend the applications of Rydberg atoms in communications.
Analysis of preoperative nutrition, immunity and inflammation correlation index on the prognosis of upper tract urothelial carcinoma surgical patients: a retrospective single center study
Authors: Ou Yong , Li Xinglan , Zheng Yang , Hu Xu , Bao Yige , Wang Dong , Chen Zhengjun , Ren Shangqing
Published: July 2023

Background: SII, PNI, SIRI, AAPR, and LIPI are prognostic scores based on inflammation, nutrition, and immunity. The purpose of this study was to examine the prognostic value of the SII, PNI, SIRI, AAPR, and LIPI in patients with UTUC who underwent radical nephroureterectomy with bladder cuff excision.
Materials and methods: Data of UTUC patients in Sichuan Provincial People's Hospital from January 2017 to December 2021 were collected. The optimal critical values of SII, PNI, SIRI, and AAPR were determined by ROC curve, and LIPI was stratified according to the dNLR and LDH. The Kaplan-Meier method was used to draw the survival curve, and Cox proportional hazard model was used to analyze the factors affecting the prognosis of UTUC patients.
Results: A total of 81 patients with UTUC were included in this study. The optimal truncation value of PNI , SII, SIRI and AAPR were determined to be 48.15, 596.4, 1.45 and 0.50, respectively. Univariate Cox proportional hazard regression showed that low PNI, high SII, high SIRI, low AAPR and poor LIPI group were effective predictors of postoperative prognosis of UTUC patients. Multivariate Cox proportional hazard regression showed that high SII was an independent risk factor for postoperative prognosis of UTUC patients. According to ROC curve, the prediction efficiency of fitting indexes of PNI, SII, SIRI, AAPR and LIPI is better than that of using them alone.
Conclusions: The SII, PNI, SIRI, AAPR, and LIPI was a potential prognostic predictor in UTUC patients who underwent radical nephroureterectomy with bladder cuff excision.
Inhibition of glutaminase suppresses the proliferation and invasion of esophageal squamous cancer cells via TGF-β/Smad and MAPK signaling pathways
Authors: Zhang Xiu , Wang Tao , Chen Yu , Huang Ming-de , Chen Kai
Published: July 2023

Accumulating evidence indicates that through its conversion of glutamine to glutamate, glutaminase (GLS) serves as a crucial player in cell proliferation and survival of different cancers. Nonetheless, the roles and mechanisms of GLS in esophageal squamous cancer have not been elucidated. Herein, we found that kidney-type GLS was overexpressed in glutamine-dependent esophageal squamous cell carcinoma (ESCC) cells and tissues. In addition, high GLS expression levels were related to a shorter survival rate than low GLS expression levels. Furthermore, knocking down GLS diminished the proliferation, migration, and invasion of ESCC cells and promoted their apoptotic rate and epithelial mesenchymal transformation (EMT) via the TGF-β/Smad canonical pathway and the TGF-β noncanonical MAPK pathway. Overall, our study showed that GLS is a therapeutic target and diagnostic biomarker for ESCC.
Global Mosquito Observations Dashboard (GMOD): a user-friendly web interface fueled by citizen science to monitor invasive and vector mosquitoes
Authors: Uelmen Johnny A. , Clark Andrew , Palmer John , Kohler Jared , Dyke Landon C. Van , Low Russanne , Mapes Connor D. , Carney Ryan M.
Published: July 2023

Background: Mosquitoes and the diseases they transmit pose a significant public health threat worldwide, causing more fatalities than any other animal. To effectively combat this issue, there is a need for increased public awareness and mosquito control campaigns. However, traditional surveillance programs are time-consuming, expensive, and lack scalability. Fortunately, the widespread availability of mobile phones with high-resolution cameras presents a unique opportunity for mosquito surveillance. In response to this, the Global Mosquito Observations Dashboard (GMOD) was developed as a free, public platform to improve the detection and monitoring of invasive and vector mosquitoes through citizen science participation worldwide.
Methods: GMOD is an interactive web interface that collects and displays mosquito observation and habitat data submitted by citizen scientists worldwide. By providing information on the locations and times of observations, the platform enables the visualization of mosquito population trends and ranges. It also serves as an educational resource, encouraging collaboration and data sharing. The data acquired and displayed on GMOD is freely available in multiple formats and can be accessed from any device with an internet connection.
Results: Since its launch less than a year ago, GMOD has already proven its value. It has successfully collected and processed large volumes of real-time data (~300,000 observations), offering valuable and actionable insights into mosquito species prevalence, abundance, and potential distributions, as well as engaging citizens in community-based surveillance programs.
Conclusions: GMOD is a cloud-based platform that provides open access to mosquito vector data obtained from citizen science programs. Its user-friendly interface and data filters make it valuable for researchers, mosquito control personnel, and other stakeholders. With its expanding data resources and the potential for machine learning advancements, GMOD is poised to support public health initiatives aimed at reducing the spread of mosquito-borne diseases in a cost-effective manner, particularly in regions where traditional surveillance methods are limited. GMOD is continually evolving, with ongoing development of powerful machine learning algorithms to identify mosquito species and other features from submitted data. The future of citizen science and artificial intelligence holds great promise, and GMOD stands as an exciting initiative in this field.
Progress towards one health approach for dog-mediated human rabies elimination in Bangladesh: on the way to zero by 30
Authors: Ghosh Sumon , Hasan Mohammad , Nath Nirmalendu , Haider Najmul , Jones Daleniece Higgins , Islam Md. , Rahaman M. Mujibur , Mursalin Hasan , Mahmud Nadim , Kamruzzam Md. , Rabby Md. Fazlay , Kar Shotabdi , Ullah Sayed , Shah Md. Rashed , Jahan Afsana , Rana Md. Sohel , Chowdhury Sukanta , Uddin Md. Jamal , Sunil Thankam , Ahmed Be-Nazir , Siddiqui Umme , Kaisar S. M. Golam , Islam Md. Nazmul
Published: July 2023

Bangladesh is making progress toward achieving zero human dog-mediated rabies deaths by 2030, a global goal set in 2015. We conducted a comprehensive analysis between the years 2011 to 2023 to understand the effectiveness of rabies control programmes and predict human rabies cases in Bangladesh by 2030 using time-series forecasting models. The human-to-dog ratio in Bangladesh was found to be 85.83, with an average dog population density of 11.51 dogs/km2. The mass dog vaccination (MDV) campaign has resulted in the vaccination of 81.46% of the estimated 3,030,662 dogs in the country. A decreasing trend from predicted and observed human rabies cases was identified, and it is projected that Bangladesh will have zero human rabies cases by 2030 if the current trend persists. The phylogenetic analysis shows that rabies viruses in Bangladesh belong to the Arctic-like-1 group. Bangladesh's efforts demonstrate that eliminating dog-mediated human rabies is achievable with a One Health approach.
Exploring the relationship between frequent cannabis use, vocal changes and language use
Authors: Olah Julianna , Chesney Edward , Oliver Dominic , Obreshkova Stiliyana , Wang Simiao , Cartier Megan , Gibbs-Dean Toni , Cummins Nicholas , Diederen Kelly , Englund Amir , Spencer Tom
Published: July 2023

Background
Cannabis use is prevalent among individuals with psychosis and a significant risk factor for the development of psychotic disorders, leading to unfavorable outcomes. Speech changes are frequently examined in psychotic disorders and connected to clinical outcomes. However, limited research investigated the impact of cannabis use on speech, which could potentially be a crucial confounding factor in the observed speech changes associated with psychosis. This study explores the differences in speech between frequent cannabis users and matched non-users.
Methods
Eight-minute speech samples from frequent cannabis users (N=82) and non-users (N=82) matched for gender, age, and education were manually transcribed and analyzed. Differences in vocal, semantic, and speech connectivity features were examined using T-tests. Logistic regression and random forest classifiers were employed to evaluate the discriminatory power of speech features.
Results
Acoustic, semantic and connectivity measures of speech showed significant differences between groups. Frequent cannabis users exhibited more voice breaks and back vowels. Connectivity analysis revealed more one-word loops in the cannabis group. Frequent users used more words, spoke coherently, and stayed on topic. Using logistic regression and random forest classifiers, participants were classified into cannabis or non-user groups with 0.66 / 0.72 accuracy (AUC = 0.62 / 0.69) based on demographic information and speech features.
Conclusions
Cannabis use is associated with alterations in speech features that overlap with those observed in psychosis. Consequently, understanding and potentially accounting for the effects of cannabis use on speech would be crucial for facilitating the treatment of psychotic disorders through speech analysis.
hPL-human adipose-derived stem cells in IKVAV-functionalised hydrogel conduit (Biogelx): an innovative delivery strategy to improve peripheral nerve repair
Authors: Guiotto Martino , Clayton Alison , Morgan Ryan , Raffoul Prof Wassim , Hart Prof Andrew , Riehle Mathis , Summa Prof Pietro di
Published: July 2023

Background.Adipose-derived stem cells (ADSC) are nowadays one of the most exploited cells in regenerative medicine. They are fast growing, capable of enhancing axonal elongation, support and locally stimulate Schwann cells (SC) and protect de-innervated muscles from atrophy after a peripheral nerve injury.Methods.With the aim of developing a bio-safe, clinically translatable cell-therapy, we assessed the effect of ADSC pre-expanded with human platelet lysate (hPL) in anin vivorat model, delivering the cells into a 15 mm critical-size sciatic nerve defect embedded within a laminin-peptide-functionalised hydrogel (Biogelx-IKVAV) wrapped by a poly--caprolactone (PCL) nerve conduit.Results.ADSC retained their stemness, their immunophenotype and proliferative activity when testedin vitro. At six weeks post implantation, robust regeneration was observed across the critical-size gap as evaluated by both the axonal elongation (anti-NF 200) and SC proliferation (anti-S100) within the Biogelx-IKVAV filled PCL conduit. All the other experimental groups manifested significantly lower levels of growth cone elongation. The histological gastrocnemius muscle analysis was comparable with no quantitative significant differences among the experimental groups.Conclusion.Taken together, these results suggest that ADSC encapsulated in Biogelx-IKVAV are a potential path to improve the efficacy of nerve regeneration. New perspectives can be pursued for the development of a fully synthetic bioengineered nerve graft for the treatment of peripheral nerve injury.
HULTIG-C: NLP Corpus and Services in the Cloud
Authors: Pais Sebastião , Cordeiro João , Jamil Muhammad
Published: July 2023

Nowadays, the use of language corpora for many purposes has increased significantly. General corpora exist for numerous languages, but research often needs more specialized corpora. The Web’s rapid growth has significantly improved access to thousands of online documents, highly specialized texts and comparable texts on the same subject covering several languages in electronic form. However, research has continued to concentrate on corpus annotation instead of corpus creation tools. Consequently, many researchers create their corpora, independently solve problems, and generate project-specific systems. The corpus construction is used for many NLP applications, including machine translation, information retrieval, and question-answering. This paper presents a new NLP Corpus and Services in the Cloud called HULTIG-C. HULTIG-C is characterized by various languages that include unique annotations such as keywords set, sentences set, named entity recognition set, and multiword set. Moreover, a framework incorporates the main components for license detection, language identification, boilerplate removal and document deduplication to process the HULTIG-C. Furthermore, this paper presents some potential issues related to constructing multilingual corpora from the Web.
Bibliometric Evaluation of Lagerstroemia
Authors: Hao Siwen , Zhang Donglin , Wen Yafeng , Zhang Wenqian , Zhao Yanghui , Jin Xiaoling
Published: July 2023

Lagerstroemia is a genus with a wide geographical range extending from Southeast Asia to Australia, and it plays a significant role in many aspects of urban life, including supporting ecosystems, beautifying cities, and affecting human health. To gain insights into the current state of Lagerstroemia research, a bibliometric analysis was conducted using 138 publications from the Web of Science core database between 2002 and 2022. The analysis involved co-occurrence analyses of authors’ affiliated institutions, a keyword co-occurrence analysis, and a timeline view of keywords. The results of the analysis revealed three stages of Lagerstroemia research: the initial stage (2002–04); the rapid growth stage (2005–13); and the in-depth stage (2014–present). Furthermore, 335 keywords from 10 clusters were identified, which indicated that genetic diversity, breeding, and landscape utilization were the three main research areas of Lagerstroemia. Collaboration among authors mainly occurred within major natural and cultivated regions, such as China and the United States. Based on the bibliometric evaluation, future research of Lagerstroemia should focus on areas such as whole-genome sequencing, male sterility problems, resistance, ornamental characteristics, and landscape utilization guidelines. The findings of this study provide an important reference for further studies and can guide the development, innovation, and application of Lagerstroemia.
Principal's competencies
Authors: Burai Renata , Burić Ivan , Bušljeta Kardum Rona
Published: July 2023

In the Republic of Croatia, being the principal of an educational institution is no longer just a function but a profession. Since 2021, the obligations and rights of principals of educational institutions derive from legal regulations, while the competencies of principals have been determined by the standard of occupation and the standard of qualification. This paper, on the basis of the Qualification and Occupational Standard - Principal of an Educational Institution, which determined the competencies of school principals of educational institutions, sought to determine the level of competencies of principals acquired through formal teacher education. Formal teacher education implies the acquisition of competencies for work in educational institutions. These competencies are acquired in the Republic of Croatia through teaching courses in graduate university studies. The survey method was used on 200 participants, primary and secondary school principals in the Republic of Croatia, to assess the level of acquired competencies, i.e., knowledge and skills, during such education that are applicable in the duties of principals. The surveyed principals expressed satisfaction with the competencies acquired in formal teacher education, especially those competencies that refer to the organizational management of the educational process and cooperation with parents and the external environment. However, the research identified groups of competencies that principals assess as insufficient. The obtained results indicate the need to implement additional training programs for principals that would enable them to acquire knowledge and skills that they have not acquired through formal education, that are crucial for the management of an educational institution.
Career competencies and employee performance: Mediating roles of job crafting and employee engagement in Islamic banking in North Sumatra, Indonesia
Authors: Andi Prayogi Muhammad , Farisi Salman , Taufik Lesmana Muhammad
Published: July 2023

This study focuses on highlighting the performance of employees in Sharia banking. The research gap in this study is the impact of job crafting on employee performance. Thus, this study aims to investigate the role of career competencies and job crafting against employee performance mediated by employee engagement of Sharia banking employees in North Sumatra, Indonesia. The paper used the stratified random sampling technique with disproportionate random samples. The sample involved 386 Sharia bank employees in North Sumatra, Indonesia. The data were analyzed using the SEM PLS approach. The hypotheses results suggest that job crafting and employee engagement have a significant impact on employee performance, job crafting has a significant effect on employees’ engagement, career competencies have a major impact on job crafting (< 0.05), career competencies do not have an impact on employee engagement and employee performance (> 0.05). Indirectly, career competencies influence employee engagement and employee performance through job crafting. Career competencies influence employee performance through job crafting and employee performance. Job crafting has a significant impact on employee performance at employee engagement < 0.05, and career competencies do not have a significant effect on employee performance through employee engagement. The implications are that job crafting has a role inherent in the individual level of an employee and as a strategy to emphasize employee engagement and employee performance in the Sharia banking sphere in North Sumatra, Indonesia.
AcknowledgmentThis study is supported by the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia for funding on categories of basic research of high-ranking University (PDUPT) Program in 2022 on Economics issue with contract number: 256/ES/PG.02.00.PT/2022 ; 120/LL1/LT/K/2022 AND 204/II.3-AU/UMSU-LP2M/C/2022. Furthermore, thanks are conveyed to all levels of management at Universitas Muhammadiyah Sumatera Utara and the leaders of the Faculty of Economics and Business. Then thanks also go to BSI (Bank Syariah Indonesia), Bank Muamalat, BMS (Bank Mega Syariah), and all employees of Islamic Banking in North Sumatra who have contributed to this research.
Integration of ICT in the Teaching and Learning Process at Christ the King Catholic Senior High School in the Obuasi Municipality
Authors: Issaka Mohammed
Published: July 2023

This study sought to investigate the extent to which teachers were using ICT in the teaching and learning process at Christ the King Catholic Senior High School in the Obuasi Municipality. The study also sought to find out which ICT resources were available for the teaching and learning process. Sixty teachers of different subject’s background were sampled through simple random sampling technique. Questionnaire titled ‘teachers in the Christ the King Catholic SHS background knowledge in the information and communication technology competency test’ was used to collect data. Mean served as the statistical tool for data analysis for research questions II, III and IV, while question I and V were analyzed with percentages. Findings depict that teachers were aware of ICT resources but do not utilize them while teaching. Many constraints were identified including lack of computer literacy on the part of some teachers, lack of ICT facilities, lack of funds, poor power supply, and no adequate knowledge of the use of internet among others. It was recommended that for quality assurance and for effective ICT integration in curriculum, teachers should be encouraged through workshops, seminars and conferences to be ICT literate; stake holders in education should join hands together in making ICT pedagogical and methodological issues fully integrated in the teaching and learning process in secondary education for quality assurance. Keywords: Integration, ICT, Teaching and Learning.
Cooperativismo Mineral: Limites e Potencialidades da Formalização da Atividade Garimpeira em Organizações Coletivas de Extração Mineral
Authors: da Silva Samuel Soares , De Freitas Alan Ferreira , Brandão Lopes Gabriela
Published: July 2023

A indução da constituição de cooperativas minerais tem sido uma estratégia do Estado brasileiro utilizada como meio regulatório de se garantir a organização e sustentabilidade da atividade garimpeira. Nesse sentido, questiona-se: Quais os limites e potencialidades da constituição de cooperativas minerais no Brasil? O presente estudo tem o objetivo revelar o campo organizacional do cooperativismo mineral no Estado de Minas Gerais (MG) e compreender quais são os limites e potencialidades destas organizações cooperativas após sua constituição. Por meio do neoinstitucionalismo e da concepção de campo organizacional foi possível compreender elementos de âmbito cultural e cognitivo que se apresentaram como poderosos aspectos econômicos, sociais e culturais que influenciaram diretamente na formação e constituição dessas organizações. O percurso metodológico possui abordagem qualitativa, caracteriza-se como exploratório-descritivo com método de estudo de casos múltiplos. As unidades de análise foram 18 cooperativas minerais de MG. Os principais achados demonstram que o campo organizacional estudado é heterogêneo em questão de estrutura, processos e comportamentos, apesar de possuir alguns indícios de isomorfismo. As potencialidades das cooperativas minerais estão relacionadas à legitimidade do modelo cooperativo que orienta e serve de canal com o mercado e com os próprios cooperados. Os limites são percebidos quando as cooperativas são utilizadas apenas como um meio de se conseguir o licenciamento ambiental, não havendo eficácia na relação mercadológica ou social.
Inovação no Setor de Saneamento: Estudo Bibliométrico da Produção Científica e Patentária
Authors: Dantas da Silva Kessia Caroline , Cavalcante de Amorim Miriam Cleide
Published: July 2023

Os serviços ofertados pelo setor de saneamento exigem eficiência e avanço operacional relacionados às tecnologias empregadas para qualidade de vida da população. O presente estudo objetivou mapear as produções científicas e tecnológicas inovadoras nesse setor. Foi realizada uma busca no Web of Science utilizando quatro conjuntos de palavras-chave: Innovation AND Sanitation, wastewater AND innovation, Innovation AND “water treatment” e Innovation AND “sewage”. A coleta de dados de patentes foi realizada no Orbit Intelligence, empregando a expressão “Management device and (sewage treatment or water treatment)”. Foi identificado um crescimento de registros de estudos científicos sobre inovação no saneamento nos últimos cinco anos, com a Suíça sendo o país com o maior número deles. A China destacou-se como detentora de 37,5% das tecnologias relacionadas a dispositivos que auxiliam o gerenciamento dos sistemas de tratamento de água e esgoto, com o maior número de depósitos em relação ao tema em 2018. Dessa maneira, o desenvolvimento e disseminação das produções científicas e tecnológicas na área têm muito a crescer; principalmente no Brasil, considerando sua participação insuficiente diante da falta de publicação em periódicos de impacto e a ausência de famílias de patentes requeridas por residentes brasileiros no período e temática pesquisados. O aprimoramento do setor de saneamento é possível por meio de inovações tecnológicas, que garantirão seu desempenho eficaz.
De la Ortodoxia de los 90 al “Post Consenso De Washington”: el Enfoque De GVC en los Organismos Financieros Internacionales
Authors: Trevignani Manuel Facundo
Published: July 2023

Hacia finales de los 90, el desprestigio de las políticas enmarcadas en el Consenso de Washington desembocó en una progresiva reorientación de la agenda del desarrollo en la comunidad internacional. A inicios del nuevo siglo, la perspectiva que vino a llenar este vacío conceptual fue el enfoque de Cadenas Globales de Valor (GVC), presentado como una nueva herramienta para analizar la reconfiguración productiva del sistema capitalista. A medida que su marco teórico ganaba relevancia en los círculos académicos, sus principales aportes comenzaron a ser introducidos en una diversidad de organismos internacionales para la formulación de políticas públicas, erigiendo al enfoque de GVC en la nueva estrategia de desarrollo para los países periféricos. Este trabajo busca realizar un estudio crítico acerca del viaje conceptual seguido por GVC en su asimilación por parte de dos organismos financieros internacionales: el Banco Interamericano de Desarrollo y el Banco Mundial.
Web 2.0 Kullanıcılarının Haber Tüketim Motivasyonları ve Tercihleri
Authors: ATEŞGÖZ Kenan , KILIÇ Deniz
Published: July 2023

Bu çalışmada, Kullanımlar ve Doyumlar Kuramı çerçevesinde Web 2.0 kullanıcılarının haber takibinde kullandıkları YouTube, Instagram ve haber sitesi-dijital gazete araçlarına yönelik motivasyonların ortaya koyulması ve bu motivasyonların karşılaştırılması amaçlanmaktadır. Çalışma örneklemini ön lisans ve lisans düzeyinde öğrenim gören 1062 Web 2.0 kullanıcısı oluşturmaktadır. Çalışmada veri toplama aracı olarak haber alma pratikleri, haber alınan mecralar ve haber kategorileriyle ilişkili semantik yapıda bir matris ile “Haber Tüketim Motivasyonları ve Tatminleri” ölçeği kullanılmıştır. Ölçek 7'li Likert tipinde olup 27 maddeden oluşmaktadır. Ölçekte “Eğlence ve Dinlenme”, “Güvenilirlik”, “Teknik İmkanlar ve Kolaylık”, “Zengin ve İsteğe Bağlı İçerik” ve “Aktif Katılım” olmak üzere 5 farklı haber tüketim motivasyonu belirlenmiştir. Matrislerden toplanan veriler betimsel analizlerle analiz edilmiştir. Araştırma bulguları, Web 2.0 kullanıcılarının YouTube'a karşı daha olumlu, haber sitesi-dijital gazeteye karşı daha olumsuz tutuma sahip olduğunu göstermiştir. Buna rağmen Web 2.0 kullanıcılarının çoğunun haber kategorisinde haber sitesi-dijital gazeteyi kullanmayı tercih ettiği gözlemlenmiştir. Web 2.0 kullanıcılarının YouTube, Instagram ve haber sitesi-dijital gazetedeki haber tüketim motivasyonlarını karşılaştırmak için tekrarlı ölçümler için tek faktörlü ANOVA yapılmıştır. Analiz sonuçları, haber takibinde her bir aracın farklı motivasyonlarla kullanıldığına dair kanıt sağlamıştır. Sonuç olarak haber medyasındaki teknolojik altyapılar ve fırsatlar zenginleştikçe izleyicilerin motivasyonlarının değiştiği tespit edilmiştir.
Dindar Yeni Orta Sınıfa Dair Bir İnceleme: Çatlak ile İki Şafak Arasında Filmlerinde Hane ve Dışarısı
Authors: TARHAN Belgin
Published: July 2023

2000’lerden bu yana Türk sinemasında, dinî değer ve geleneklerin referansında yaşayan dindar toplumsal kesimlerin temsili çeşitlilik göstermekte ve çoğalmaktadır. Ana akım Türk sinemasındaki gerici, yobaz, dinbaz tiplemeler sunan yapımları aşarak dindarlığı sosyolojik bir saikle yorumlayan filmler artmaktadır. Çatlak (Fikret Reyhan, 2020) ile İki Şafak Arasında (Selman Nacar, 2021) filmleri, bu yeni bakışı yansıtan örnekler olarak öne çıkmaktadır. İki yapımın odağında, sosyo-ekonomik olarak taşradan/çevreden gelen, dinî vecibelere göre yaşamaya çalışırken çevresini kuşatan modern yaşantıyla uyumlaşma süreci geçirmekte olan dindar yeni orta sınıf aile yer almaktadır. Dindar yeni orta sınıfa içeriden yaklaşan sinematografileri, iki filmi yan yana getirmektedir. Bu nitelikleriyle iki film, çeperine ya da merkezine dindarlığı koyan kendilerinden önceki yapımlardan ayrılmaktadırlar. Bu çalışma iki filmin sunduğu sinematografik göstergeleri yorumlayarak sosyolojik bir inceleme sunmayı amaçlamaktadır. Din, dindarlık, inanç, Müslümanlık gibi kavramlara yer verilmekle birlikte bu çalışma İslam inancının özüyle değil, yaşamlarının merkezine dini yerleştiren toplumun dindar kesimlerinin gündelik pratikleriyle ilgilidir. Çalışmada, hane içindeki ve kamusal hayattaki ikili hâl bilgisayar ve ağ teknolojilerinden ödünç alınan çevrimiçi ve çevrimdışı kavramları aracılığıyla ortaya konmaktadır. Çevrimiçi ve çevrimdışı kavramları hem hanede hem de kamusal yaşamda üzeri örtülen bireysel istekler ile ahlaki ikilemleri göstermektedir. İki film aracılığıyla dindar yeni orta sınıfın hane içi ve dışındaki yaşam pratikleri yorumlanarak ikili ahlak ve adalet anlayışından doğan sorunlar tartışmaya açılmaktadır.
FETÖ’nün Şii Haşhaşiler ve Sünni Kadiyaniler ile Yapısal Benzerlikleri: Sistematik Değerlendirme
Authors: GÜR Ali
Published: July 2023

Yaklaşık elli yıl kadar önce görünürde dinî bir yapılanma olarak yola çıkıp 15 Temmuz’da terör örgütüne dönüşen Fethullahçı Terör Örgütü (FETÖ)’nün esinlendiği tarihî ve çağdaş dinî hareketlerin iyi analiz edilmesi ve benzeşen yöntemlerinin belirlenmesi mücadele stratejisi ve gelecek projeksiyonu açısından önem arz etmektedir. Ulaşılabilen açık kaynaklardan yapılan taramalar neticesinde bu konu ile ilgili örgütler arası benzerlikleri çoklu başlıklar altında sistematik olarak ele alan kapsamlı bir çalışmaya rastlanılamamıştır. Çoklu açık kaynaklardan elde edilen verilerle üçü kuruluş tarihçesi, kırkı da örgütsel yapısı ile ilgili olmak üzere toplamda kırk dört başlık altında FETÖ’nün temel tanımlayıcı özellikleri belirlendi. Belirlenen bu özellikler çerçevesinde FETÖ’nün uluslararası iki örgüt olan Şii Haşhaşiler ve Sünni Kadiyaniler ile benzerlik gösteren yönlerinin tablo hâlinde sistematik olarak analiz edilmesi ve tartışılması amaçlandı. Bu konu üzerine yapılan ilk kapsamlı ve sistematik bir değerlendirme olması çalışmanın güçlü yönünü oluşturmaktadır. Çalışma, FETÖ’nün Şii-Nizari Haşhaşilerle kırk alt başlığın otuzunda benzerlik gösterirken Sünni-Hanefi Kadiyaniler ile de yirmi sekiz alt başlıkta benzerlik gösterdiğini saptamıştır. Bu durum Şii ve Sünni gibi tamamen farklı iki mezhepsel akımın FETÖ’ye kaynaklık etmede farklılık göstermediğini sadece bazı alt başlıkların bir örgütte daha baskın olduğunu düşündürmüştür. Farklı coğrafya ve sosyokültürel ortamlarda olmalarına rağmen elli yıllık bir FETÖ örgütünün, bin yıllık Şii Haşhaşilerle ve yüz elli yıllık Sünni Kadiyanilerle böylesine benzerlik göstermesinin güncel sonuçlarının iyi değerlendirilmesi önem arz etmektedir.
Örnek Bir Yeraltı Metal Madeninde Simülasyon Yazılımı ile Yangın Senaryoları Hazırlanıp Değerlendirilmesi
Authors: İNAL Hasan Onur , KAHRAMAN Bayram
Published: July 2023

Yeraltı madenciliğinde havalandırma, işçi sağlığı ve güvenliği için hayati öneme sahiptir. Havalandırma sistemi tasarımı ve işletilmesi için simülasyon teknikleri kullanmak, doğru havalandırma sistemlerinin tasarlanmasına ve işletilmesine yardımcı olabilir. Bu nedenle, yeraltı madenciliğinde havalandırma ve simülasyon teknikleri, maden işletmeciliğinin önemli bir parçası haline gelmiştir. Simülasyonlar, havalandırma sisteminin tasarımı ve işletilmesi için gerekli hava akış hızı, basınç düşüşü ve hava kalitesi gibi parametrelerin belirlenmesine kullanılmaktadır. Simülasyonlar ayrıca, havalandırma sistemlerinin farklı senaryolarda nasıl çalışacağını ve potansiyel sorunları belirleyebilmektedir. Bu çalışmada Ventsim yazılımı yardımıyla farklı yangın senaryoları değerlendirilerek acil durum eylem planları hazırlanmasına nasıl katkı verilebileceğini göstermek amaçlanmıştır.
Enine Zemin Hareketine Maruz Gömülü Boru Hatlarının Tepkisi İçin Örnek Bir Çalışma
Authors: YİĞİT Adil
Published: July 2023

Yaşam hatları olarak adlandırılan gömülü boru hatları, parçalı ve sürekli boru hatları olarak sınıflandırılmaktadır. Söz konusu bu altyapıların güvenliği insan hayatı için üst yapılar kadar önemlidir. Bu çalışmada, İstanbul ili Esenyurt ilçesi 2126. Sokak’ta meydana gelen düşey zemin deplasmanı nedeniyle bu bölgede gömülü olan parçalı ve sürekli boru hatları incelenmiştir. İnceleme alanında 20 cm zemin oturması tespit edilmiştir. Bu zemin oturmasına konu olan bölgede hem sürekli (24” çelik, Ø1400 çelik ve PE125 polietilen) hem de parçalı (Ø300 beton ve 100DF düktil) gömülü boru hatlarının davranışı enine kalıcı zemin deformasyonuna göre incelenmiş ve elde edilen sonuçlar irdelenmiştir. Yapılan analizler sonucunda bölgede mevcut olan boru hatlarının söz konusu zemin hareketine karşı güvenli olduğu ancak lokal burkulma incelemeleri sonucunda polietilen doğalgaz boru hattında (PE125) hasar oluşabileceği tespit edilmiştir.
Analysing The Effects of Knitted Fabrics Physical Properties to The Heating of Sewing Machine Needles
Authors: AKÇAGÜN Engin , YILMAZ Abdurrahim , KAYAR Mahmut
Published: July 2023

Due to the increasing demand in the clothing industry, industrial sewing machines operate at high speeds ranging from 2000 to 3000 revolutions per minute. One of the most significant problems that adversely affect the stitching quality and efficiency is the needle temperature, which reaches up to 300 oC and is influenced by various parameters such as machine speed, thread tension, and fabric properties. In this study, the heat generated from the friction between the needle and the textile surface in knitted fabrics and the fabric properties affecting heat are examined. Four different knitting techniques and twelve different knitted fabrics with varying weights, thicknesses, and blend properties were used. An Optris CT3M pyrometer was employed to measure the temperature on the needle. The results can be summarized as follows: in all knitted fabrics, an increase in fabric weight and thickness was observed to correspond to an increase in needle temperature values. The highest needle temperature values above 90 oC were obtained in TF2-coded three-thread fleece fabric with a fabric thickness of 1.31 mm and a fabric weight of 340 g/m2, while the lowest needle temperatures of 66 oC and below were achieved in the lightest and thinnest fabric with a fabric weight of 100 g/m2 and a thickness of 0.39 mm. Additionally, no significant relationship was found between fabric stitching density and needle temperature.
Çift-Girişim Tabanlı İyileştirme Algoritmasının Sayısal İyileştirme Fonksiyonları Üzerinde Performans Analizi
Authors: KÖSE ULUKÖK Mehtap
Published: July 2023

Sayısal iyileştirme, mühendislik alanında en çok uğraşılan problemlerden biridir. Bu çalışmada, son zamanlarda geliştirilen Çift-Girişim Tabanlı İyileştirme Algoritması’nın (Bi-Attempted Based Optimization Algorithm) (ABaOA) arama yakınsama kabiliyeti yirmi iyi bilinen referans fonksiyonu üzerinde test edilmiştir. Elde edilen sonuçlar Genetik Algoritma (GA) ve Temel İyileştirme Algoritması (Based Optimization Algoritması) (BaOA) ile karşılaştırılmıştır. ABaOA, tüm yinelemeler boyunca iki sabit adım boyutlu çoğaltma parametresi ve iki işlem operatörü kullanan nüfus tabanlı bir Evrimsel Algoritma’dır. Evrimsel algoritmalar arama alanı boyunca global optimuma hızlı bir şekilde yaklaşır ve uygulanabilir bir çözümü garanti ederler. Deneysel sonuçlar ABaOA'nın hem BAOA'ya hem de GA'ya göre global optimuma daha hızlı yaklaştığını açıkça göstermiştir.