bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical significance of clonal hematopoiesis in the setting of autologous stem cell transplantation for lymphoma
Authors: Lackraj Tracy , Ben Barouch Sharon , Medeiros Jessie J. F. , Pedersen Stephanie , Danesh Arnavaz , Bakhtiari Mehran , Hong Michael , Tong Kit , Joynt Jesse , Arruda Andrea , Minden Mark D. , Kuruvilla John , Bhella Sita , Kukreti Vishal , Crump Michael , Prica Anca , Chen Christine , Deng Yangqing , Xu Wei , Pugh Trevor J. , Keating Armand , Dick John E. , Abelson Sagi , Kridel Robert
Published: September 2022

Autologous stem cell transplantation (ASCT) remains a key therapeutic strategy for treating patients with relapsed or refractory non‐Hodgkin and Hodgkin lymphoma. Clonal hematopoiesis (CH) has been proposed as a major contributor not only to the development of therapy‐related myeloid neoplasms but also to inferior overall survival (OS) in patients who had undergone ASCT. Herein, we aimed to investigate the prognostic implications of CH after ASCT in a cohort of 420 lymphoma patients using ultra‐deep, highly sensitive error‐correction sequencing. CH was identified in the stem cell product samples of 181 patients (43.1%) and was most common in those with T‐cell lymphoma (72.2%). The presence of CH was associated with a longer time to neutrophil and platelet recovery. Moreover, patients with evidence of CH had inferior 5‐year OS from the time of first relapse (39.4% vs. 45.8%, p = .043) and from the time of ASCT (51.8% vs. 59.3%, p = .018). The adverse prognostic impact of CH was not due to therapy‐related myeloid neoplasms, the incidence of which was low in our cohort (10‐year cumulative incidence of 3.3% vs. 3.0% in those with and without CH, p = .445). In terms of specific‐gene mutations, adverse OS was mostly associated with PPM1D mutations (hazard ratio (HR) 1.74, 95% confidence interval (CI) 1.13–2.67, p = .011). In summary, we found that CH is associated with an increased risk of non‐lymphoma‐related death after ASCT, which suggests that lymphoma survivors with CH may need intensified surveillance strategies to prevent and treat late complications.
Proximal urea cycle defects are challenging to detect with newborn screening: Results of a prospective pilot study using post‐analytical tools
Authors: Hall Patricia Liane , Wittenauer Angela Lynn , Wilcox William Ross
Published: September 2022

The purpose of this pilot project was to evaluate the efficacy of the Collaborative Integrated Laboratory Reports (CLIR) postanalytical tools from Mayo Clinic for detection of newborns with proximal urea cycle disorders (PUCD) in the Georgia newborn screening program that uses the underivatized Neobase2 kit (Perkin Elmer). We evaluated 138,560 newborn screening (NBS) samples (between 125,000 and 130,000 children) and used the CLIR result interpretation guidelines to stratify results. Children at higher risk of having a PUCD received follow‐up services including confirmatory lab testing (ammonia, plasma amino acids, urine orotic acid) or a repeat NBS sample. We made multiple adjustments to our CLIR PUCD tool and to our follow‐up algorithms in order to reduce false positives. Regardless, a high number of NBS samples resulted with false positives in part due to the glutamine peak also containing lysine. No children were diagnosed with a PUCD during our study period, and the Emory Genetics Metabolic Center is unaware of any children diagnosed outside of the NBS system during that time. Based on our experience, PUCD is not suitable for statewide NBS using Neobase2 and CLIR. Other methodologies that can separate glutamine from other amino acids may have better performance.
Biomarkers for dementia in Latin American countries: Gaps and opportunities
Authors: Parra Mario A. , Orellana Paulina , Leon Tomas , Victoria Cabello G. , Henriquez Fernando , Gomez Rodrigo , Avalos Constanza , Damian Andres , Slachevsky Andrea , Ibañez Agustin , Zetterberg Henrik , Tijms Betty M. , Yokoyama Jennifer S. , Piña‐Escudero Stefanie D. , Cochran J. Nicholas , Matallana Diana L. , Acosta Daisy , Allegri Ricardo , Arias‐Suárez Bianca P. , Barra Bernardo , Behrens Maria Isabel , Brucki Sonia M. D. , Busatto Geraldo , Caramelli Paulo , Castro‐Suarez Sheila , Contreras Valeria , Custodio Nilton , Dansilio Sergio , la Cruz‐Puebla Myriam De , de Souza Leonardo Cruz , Diaz Monica M. , Duque Lissette , Farías Gonzalo A. , Ferreira Sergio T. , Guimet Nahuel Magrath , Kmaid Ana , Lira David , Lopera Francisco , Meza Beatriz Mar , Miotto Eliane C. , Nitrini Ricardo , Nuñez Alberto , O'Neill Santiago , Ochoa John , Pintado‐Caipa Maritza , Resende Elisa de Paula França , Risacher Shannon , Rojas Luz Angela , Sabaj Valentina , Schilling Lucas , Sellek Allis F. , Sosa Ana , Takada Leonel T. , Teixeira Antonio L. , Unaucho‐Pilalumbo Martha , Duran‐Aniotz Claudia
Published: September 2022

Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.
Synthesis and Upper Bound of Schmidt Rank of Bipartite Controlled‐Unitary Gates
Authors: Jiang Gui‐Long , Wei Hai‐Rui , Song Guo‐Zhu , Hua Ming
Published: September 2022

Quantum circuit model is the most popular paradigm for implementing complex quantum computation. Based on Cartan decomposition, it is shown generalized controlled‐X (GCX) gates, 6 single‐qubit rotations about the y‐ and z‐axes, and single‐partite y‐ and z‐rotation‐types which are defined in this paper are sufficient to simulate a controlled‐unitary gate with controlling on . In the scenario of the unitary gate with that is locally equivalent to a diagonal unitary on , GCX gates and single‐partite y‐ and z‐rotation‐types are required to simulate it. The quantum circuit for implementing and are presented. Furthermore, it is found that with controlling has Schmidt rank two, and in other cases the diagonalized form of the target unitaries can be expanded in terms of specific simple types of product unitary operators.
Substrate Tumbling in a Chemisorbed Diastereomeric α‐Ketoester/1‐(1‐Naphthyl)ethylamine Complex
Authors: Dong Yi , Lemay Jean‐Christian , Zeng Yang , Groves Michael N. , McBreen Peter H.
Published: September 2022

Scanning tunneling microscopy (STM) data for α‐ketoester/1‐(1‐naphthyl)ethylamine complexes on Pt(111) reveal a tumbling motion that couples two neighboring binding states. The interconversion, resulting in prochiral inversion of the α‐ketoester, occurs in single complexes without breaking them apart. This is a surprising observation because the overall motion requires rotation of the α‐ketoester away from the surface without branching exclusively into diffusion away from the complex or desorption. The multi‐step interconversion is rationalized in terms of sequences of bound states that combine transient H‐bond interactions with the chiral molecule and weakened adsorption interactions with the metal. The observation of tumbling in single long‐lived complexes is of relevance to self‐assembly and directed molecular motion on surfaces, to ligand‐controlled surface reactions, and most directly to stereocontrol in asymmetric heterogeneous catalysis.
C(sp3)−H Hydroxylation in Diiron β‐Hydroxylase CmlA Transpires by Amine‐Assisted O2 Activation Avoiding FeIV2O2 Species
Authors: Lu Jiarui , Lai Wenzhen , Chen Hui
Published: September 2022

Through QM/MM modeling, we discovered that C(sp3)−H β‐hydroxylation in the diiron hydroxylase CmlA transpires by traceless amine‐assisted O2 activation. Different from the canonical diiron hydroxylase sMMO, this aliphatic‐amine‐assisted O2 activation avoids generating the high‐valent diferryl FeIV2O2 species, but alternatively renders a diferric FeIII2O species as the reactive oxidant. From this unprecedented O2 activation mode, the derived C(sp3)−H hydroxylation mechanism in CmlA also differs drastically from the toluene aromatic C(sp2)−H hydroxylation in the diiron hydroxylase T4MO. This substrate‐modulated O2 activation in CmlA has rich mechanistic implications for other diiron hydroxylases with an amine group adjacent to the C−H bond under hydroxylation in substrates, such as hDOHH. Furthermore, the adapted coordination environment of the diiron cofactor upon O2 binding in CmlA opens up more structural and mechanistic possibilities for O2 activation in non‐heme diiron enzymes.
Atroposelective Access to 1,3‐Oxazepine‐Containing Bridged Biaryls via Carbene‐Catalyzed Desymmetrization of Imines
Authors: Yang Xing , Wei Liwen , Wu Yuelin , Zhou Liejin , Zhang Xinglong , Chi Yonggui Robin
Published: September 2022

We disclose herein an atroposelective synthesis of novel bridged biaryls containing medium‐sized rings via N‐heterocyclic carbene organocatalysis. The reaction starts with addition of the carbene catalyst to the aminophenol‐derived aldimine substrate. Subsequent oxidation and intramolecular desymmetrization lead to the formation of 1,3‐oxazepine‐containing bridged biaryls in good yields and excellent enantioselectivities. These novel bridged biaryl products can be readily transformed into chiral phosphite ligands. Preliminary density function theory calculations suggest that the origin of enantioselectivity arises from the more favorable frontier molecular orbital interactions in the transition state leading to the major product.
A Bifunctional CdS/MoO2/MoS2 Catalyst Enhances Photocatalytic H2 Evolution and Pyruvic Acid Synthesis
Authors: Bie Chuanbiao , Zhu Bicheng , Wang Linxi , Yu Huogen , Jiang Chenhui , Chen Tao , Yu Jiaguo
Published: September 2022

The best use of photogenerated electrons and holes is crucial to boosting photocatalytic activity. Herein, a bifunctional dual‐cocatalyst‐modified photocatalyst is constructed based on CdS/MoO2/MoS2 hollow spheres for hydrogen evolution coupled with selective pyruvic acid (PA) production from lactic acid (LA) oxidation. MoS2 and MoO2 are simultaneously obtained from the conversion of CdMoO4 in one step. In a photocatalytic process, the MoS2 and MoO2 function as the reduction and oxidation centers on which photogenerated electrons and holes accumulate and are used for hydrogen evolution reaction (HER) and PA synthesis, respectively. By monitoring the intermediates, a two‐step single‐electron route for PA production is proposed, initiated by the cleavage of the α‐C(sp3)−H bond in the LA. The conversion of LA and the selectivity of PA can reach ca. 29 % and 95 % after a five‐hour reaction, respectively.
Copper‐amine complex immobilized on nano NaY zeolite as a recyclable nanocatalyst for the environmentally friendly synthesis of 2‐amino‐4H‐chromenes
Authors: Azizi Amiri Mohammadreza , Pasha Ghasem Firouzzadeh , Tajbakhsh Mahmood , Asghari Sakineh
Published: September 2022

The nano NaY zeolite‐supported copper‐amine complex was prepared by postmodification of the nano NaY zeolite with 3‐chloropropyl trimethoxysilane (CPTMS) and [2‐({3‐[(2‐aminoethyl)thio]propyl}thio)ethyl]amine followed by coordination with Cu (I) ion. Various techniques such as Fourier transform infrared spectroscopy (FT‐IR), X‐ray powder diffraction (XRD), dynamic light scattering (DLS), thermogravimetric analysis (TGA),  differential thermal analysis (DTA), scanning electron micrograph (SEM), transmission electron microscopy (TEM), Brunauer–Emmett–Teller (BET), t‐plot, energy dispersive spectroscopy (EDS), inductively coupled plasma (ICP), and elemental analyses were used to characterize the structure of the synthesized catalyst. The catalytic activity of the synthesized nano‐sample was evaluated in a three‐component synthesis of 2‐amino‐4H‐chromene derivatives, which resulted in high reaction yields and short reaction times under green conditions. The catalyst is separated by filtration and can be reused for at least seven consecutive runs without significant loss of catalytic activity. The nature of the supported [2‐({3‐[(2‐aminoethyl)thio]propyl}thio)ethyl]amine (NN) on the zeolite's surface improved the catalytic activity of the zeolite, provided homogeneity to the catalyst, and enhanced the capability of coordination with copper ions. Facile catalyst recovery and reuse, simple setup procedure and generality of the method, high turnover number (TON), and aqueous ethanol as a green solvent make this procedure an environmentally benign approach for preparing the titled heterocycles. The findings in this work revealed that the introduced catalytic system could be used to prepare other beneficial heterocyclic compounds under environmentally benign conditions.
Luminol immobilized on the metal–organic framework: As an efficient and highly sensitive sensor for the detection of antibiotics in aqueous medium
Authors: Kiani Ameneh , Alinezhad Heshmatollah , Nemati Afsaneh , Chaichi Mohammad Javad
Published: September 2022

In this research, an anionic metal–organic framework (MOF) with the general formula of [HDMA]2[Zn2(BDC)3(DMA)2]·6DMF (HDMA+: dimethylamonnium, BDC2−: 1,4‐benzenedicarboxilate, DMA: dimethylamine, and DMF: N,N′‐dimethylformamide), namely, TMU‐3, was synthesized by the solvothermal method and then modified with the chemiluminescent reagent of luminol via post‐synthetic modification. The Luminol@TMU‐3 was incorporated as an ideal sensor for the immediate detection of four kinds of antibiotics such as cephalexin, amoxicillin, ampicillin, and 6‐aminopenicillanic acid (6‐APA) in aqueous media. Based on the results, Luminol@TMU‐3 exhibits high throughput and high efficiency of luminescent intensity, and the limit of detection (LOD) of cephalexin (in the 0.001 to 1000 μM concentration range), amoxicillin (in the 0.05 to 100 μM concentration range), ampicillin (in the 0.05 to 100 μM concentration range), and 6‐APA (in the 0.001 to 500 μM concentration range) is estimated to be 0.00005, 0.0001, 0.00012, and 0.00003 μM, respectively. High sensitivity, high throughput, and high fidelity are some of the notable features of this unique diagnostic platform, which can act as a universal device in the quantitative and rapid recognition of a wide range of analytes.
Long‐term monitoring shows that drought sensitivity and riparian land use change coincide with freshwater mussel declines
Authors: Lopez Jonathan W. , DuBose Traci P. , Franzen Alex J. , Atkinson Carla L. , Vaughn Caryn C.
Published: September 2022

Freshwater mussels (Bivalvia: Unionoida) are globally imperilled and are the subjects of wide‐ranging conservation initiatives. This study combined traditional species‐monitoring surveys with a novel functional trait classification scheme and publicly available environmental data to assess potential environmental drivers of declining mussel abundance and species richness.

Surveys to document mussel abundance and assemblage composition in south‐east Oklahoma, United States were conducted on the Glover, Mountain Fork and upper Little rivers. Present day survey results (2015–2021) were compared with those from previous studies (1993–1999, 2010) to document long‐term changes in the species and functional composition of mussel assemblages and concurrent changes in climate and land use.

Mussel catch per unit effort declined by 71.5% between historical and present day surveys. Species richness declined by 44.4% over this same period. Using a novel classification of mussel drought sensitivity, it was found that the declines were associated with a disproportionate loss of drought‐sensitive taxa (67.0% decline) – those classified as drought‐tolerant did not decline in abundance. Mussel declines coincided with the loss of open surface waters (such as streams, ponds and lakes) and riparian wetlands, increased local air temperatures and longer and more intense hydrological drought.

These findings indicate that for a complete understanding of the causes and consequences of mussel declines, conservation biologists must not only monitor the species composition and abundance of threatened organisms, but also consider functional traits. The results further underscore the importance of long‐term monitoring for long‐lived organisms owing to the decadal time scales over which climate and land use change occur.
Parasympathetic withdrawal indexes risk for emotion dysregulation in children with autism spectrum disorder
Authors: Baker Jason K. , Fenning Rachel M. , Erath Stephen A. , Fabian Sarah
Published: September 2022

Children with autism spectrum disorder (ASD) experience significant difficulties with emotion regulation. Theory and empirical evidence suggest substantial biological contributions to regulatory challenges, which may be related to core ASD symptoms. Respiratory sinus arrythmia (RSA) is a measure of parasympathetic nervous system activity that serves as a putative biomarker for emotion regulation. Higher baseline RSA and more RSA reactivity (parasympathetic withdrawal; RSA‐R) in response to challenge appear adaptive in non‐clinical populations, but existing evidence for children with ASD remains inconclusive. The current study examined correlates of observed emotion dysregulation in 61 children with ASD between the ages of 6 and 10 years, including ASD symptom levels as well as both baseline RSA and concurrent RSA reactivity. Consistent with previous research, ASD symptom level was significantly correlated with observed dysregulation whereas additional factors such as child IQ were not. Baseline RSA was unrelated to observed dysregulation, but higher RSA reactivity predicted concurrent dysregulation above and beyond the contribution of child ASD symptoms. Findings contribute to an emerging understanding of dysregulation in these children, raise questions about the utility of traditional baseline RSA measures for this population, and clarify the functional significance of RSA reactivity as a risk factor for emotion dysregulation in children with ASD.
Ambiphilic singlet carbenes: Electron donors and acceptors
Authors: Kim Hyunho , Lee Eunsung
Published: September 2022

The isolation of cyclic(alkyl)(amino)carbenes (CAACs) and N,N′‐diamidocarbenes (DACs) has opened up new avenues in the field of carbene chemistry due to their unique properties. CAACs are strong σ‐donors and π‐acceptors, whereas DACs are extremely strong π‐acceptors. The ambiphilicity of carbenes can facilitate new applications such as small molecule activation and catalysis. Since the isolation of CAACs and DACs, several new ambiphilic carbenes have been synthesized, thereby advancing the development of carbene chemistry. This review summarizes the most relevant findings on ambiphilic carbene chemistry until 2022.
Gene therapy using genome‐edited iPS cells for targeting malignant glioma
Authors: Tamura Ryota , Miyoshi Hiroyuki , Imaizumi Kent , Yo Masahiro , Kase Yoshitaka , Sato Tsukika , Sato Mizuto , Morimoto Yukina , Sampetrean Oltea , Kohyama Jun , Shinozaki Munehisa , Miyawaki Atsushi , Yoshida Kazunari , Saya Hideyuki , Okano Hideyuki , Toda Masahiro
Published: September 2022

Glioblastoma is characterized by diffuse infiltration into the normal brain. Invasive glioma stem cells (GSCs) are an underlying cause of treatment failure. Despite the use of multimodal therapies, the prognosis remains dismal. New therapeutic approach targeting invasive GSCs is required. Here, we show that neural stem cells (NSCs) derived from CRISRP/Cas9‐edited human‐induced pluripotent stem cell (hiPSC) expressing a suicide gene had higher tumor‐trophic migratory capacity compared with mesenchymal stem cells (MSCs), leading to marked in vivo antitumor effects. High migratory capacity in iPSC‐NSCs was related to self‐repulsive action and pathotropism involved in EphB‐ephrinB and CXCL12‐CXCR4 signaling. The gene insertion to ACTB provided higher and stable transgene expression than other common insertion sites, such as GAPDH or AAVS1. Ferroptosis was associated with enhanced antitumor immune responses. The thymidylate synthase and dihydroprimidine dehydrogenase expressions predicted the treatment efficacy of therapeutic hiPSC‐NSCs. Our results indicate the potential benefit of genome‐edited iPS cells based gene therapy for invasive GSCs. Furthermore, the present research concept may become a platform to promote clinical studies using hiPSC.
Fluid mechanical performance of ureteral stents: The role of side hole and lumen size
Authors: Zheng Shaokai , Obrist Dominik , Burkhard Fiona , Clavica Francesco
Published: September 2022

Ureteral stents are indispensable devices in urological practice to maintain and reinstate the drainage of urine in the upper urinary tract. Most ureteral stents feature openings in the stent wall, referred to as side holes (SHs), which are designed to facilitate urine flux in and out of the stent lumen. However, systematic discussions on the role of SH and stent lumen size in regulating flux and shear stress levels are still lacking. In this study, we leveraged both experimental and numerical methods, using microscopic‐Particle Image Velocimetry and Computational Fluid Dynamic models, respectively, to explore the influence of varying SH and lumen diameters. Our results showed that by reducing the SH diameter from to the median wall shear stress levels of the SHs near the ureteropelvic junction and ureterovesical junction increased by over , even though the flux magnitudes through these SH decreased by about . All other SHs were associated with low flux and low shear stress levels. Reducing the stent lumen diameter significantly impeded the luminal flow and the flux through SHs. By means of zero‐dimensional models and scaling relations, we summarized previous findings on the subject and argued that the design of stent inlet/outlet is key in regulating the flow characteristics described above. Finally, we offered some clinically relevant input in terms of choosing the right stent for the right patient.
Who really needs a Metaverse in anatomy education? A review with preliminary survey results
Authors: Iwanaga Joe , Muo Edward C. , Tabira Yoko , Watanabe Koichi , Tubbs Susan J. , D'Antoni Anthony V. , Rajaram‐Gilkes Mathangi , Loukas Marios , Khalil Mohammed K. , Tubbs R. Shane
Published: September 2022

The term Metaverse (“meta” defined as beyond, transcendence or virtuality, and “verse” meaning universe or world) denotes a “virtual reality space” for anatomy teaching. To ascertain how many anatomists are familiar or are using this adjunct in teaching, we conducted a short survey at the 2022 annual meeting of the American Association of Clinical Anatomists (AACA). Interestingly, only six respondents (9.4%) had used a Metaverse for teaching anatomy. Moreover, the vast majority of attendees were anatomy educators or basic science faculty, but not practicing physicians/surgeons or other actively practicing health care professionals; a group where this technology has been used much more commonly. The present manuscript was authored by anatomy educators, practicing physicians and other actively practicing health care professionals with backgrounds in diverse medical fields, that is, anatomists, medical doctors, physician assistants, dentists, occupational therapists, physical therapists, chiropractors, veterinarians, and medical students. Many of these authors have used or have been exposed to a Metaverse in the clinical realm. Therefore, the aim of the paper is to better understand those who are knowledgeable of a Metaverse and its use in anatomy education, and to provide ways forward for using such technology in this discipline.
Combining expression of RNF43 and infiltration level of CD163+ tumor associated macrophage predicts prognosis of clear cell renal cell carcinoma
Authors: Zhu Dawei , Shi Xiaokai , Tian Yijun , Li Hao , Tang Bowen , Zhang Ziyi , Zhang Ze , Zuo Li
Published: September 2022

Searching for reliable indicators for evaluating prognosis diagnosed with clear cell renal cell carcinoma (ccRCC) is crucial for improving clinical therapies. However, current researches have looked mainly at the prognostic value of a single intratumoral indicator, neglecting tumor‐infiltrating immune cells (TIICs) in the microenvironment. This study examined whether the integration of Ring finger protein 43 (RNF43) expression and CD163+ tumor‐associated macrophage (TAM) infiltration in combination with clinical indexes forecast ccRCC patient outcome with relatively high accuracy. Firstly, the expression of RNF43 and CD163 were detected with immunohistochemistry. Totally, 346 ccRCC patients were random separated evenly into training and validation datasets to make further analyses. We found that RNF43 expression was negatively correlated with infiltration level of CD163+ TAM in ccRCC, which was closely associated with the TNM stage and outcome of these patients. The multiple regression analysis demonstrated that RNF43, CD163, and TNM stage could function as independent risk factors in overall survival (OS) and progression‐free survival (PFS) prediction of ccRCC. Furthermore, a better postoperative prognosis index for ccRCC patients was obtained by combining RNF43 and CD163+ TAMs, which assessed with time‐dependent C‐index analyses and a nomogram. Consequently, combining RNF43 and CD163+ TAMs along with TNM stage acquired robust accuracy in forecasting outcome of patients with ccRCC. In conclusion, combining intratumoral RNF43 expression, CD163+ TAM infiltration, and TNM stage could significantly enhance the veracity in forecasting postoperative outcomes.
How short film ads improve brand attitudes: The roles of viewing experiences and consumption visions
Authors: Chang Chingching
Published: September 2022

This article proposes a model to predict how the content of short film ads might trigger hedonic and eudaimonic experiences, which then contribute to positive changes in attitudes toward the sponsoring brand, through two processes. In the first process, people seek branded entertainment to break away from their mundane reality. The ultimate purpose is to enjoy hedonic experiences, as might be triggered by a funny plot that induces perceptions of humor, which in turn can evoke positive affect. In the second process, consumers search for meaning through vicarious experiences, which enable them to achieve personal growth. In this process, the purpose is to find meaning or acquire eudaimonic experiences. Because a meaningful story plot explicitly encourages consumers to reflect on their lives, it helps them feel inspired and develop sentimental feelings, thus leading to eudaimonic experiences. The proposed dual process model suggests that gratification derived from viewing short film ads, due to hedonic or eudaimonic experiences, can prompt positive brand attitude changes. Moreover, consumption visions triggered by short films contribute to product changes; they moderate the first process but not the second.
The Oscars: Friends and foes for millennials
Authors: Fine Monica B. , Gironda John T. , Petrescu Maria , Dobre Costinel
Published: September 2022

This study uses a multi‐method approach to formulate a theoretical framework of movie experience evaluation based on Millennials' perceived quality of the Academy Awards and the event's relevancy concerning movie characteristics, social media usage, and eWOM‐giving. The paper is based on a conceptual framework that theorizes movies as experiences and on the service quality framework. Using national consumer survey data, we present the results of a qualitative conceptual mapping analysis focused on the themes identified by Millennials as recommendations for the Academy Awards to relate and appeal to moviegoers in their age group. The variables that affect Millennial consumers' perceived quality of the Oscars are examined further utilizing a fuzzy‐set qualitative comparative analysis (fsQCA). The qualitative and quantitative analyses expose the complexity of service, experience, and social factors contributing to Millennials' attitudes towards the Academy Awards and the combination of cues consumers use when evaluating movie experiences: objective features and socially related aspects, reference groups, and indirect traits, such as involvement in social causes.
Annual Phytochemical Variations and Antioxidant Activity within the Aerial Parts of Lavandula angustifolia, an Evergreen Medicinal Plant
Authors: Najafian Sharareh , Afshar Mahmoud , Radi Mohsen
Published: September 2022

Acknowledging the importance of medicinal compounds, flavonoids, and phenolic acids in plants and human health; understanding the best time to harvest plants to get the most potentially therapeutic biological activity; and predicting and controlling the quality of medicinal plants are very useful. The rich chemical composition of medicinal lavender, as well as its antioxidant activity, has led to its wide application in the pharmaceutical, cosmetic, and food industries. In the current research, seasonal differences in phenolic content; the main constituents of essential oil, essential oil yield, and antioxidant activity; and flavonoid content were evaluated. In this investigation, for all the investigated factors, three replications were considered as completely randomized designs. The predominant natural components were α‐pinene, camphene, 1,8‐cineole, limonene, camphor, borneol, cryptone, isobornyl formate, cumin aldehyde, carvone, caryophyllene oxide, and epi‐α‐cadinol. The highest rate of 1,8‐cineole was seen in summer, while camphor and borneol showed their highest percentages in the cold season. Some of the compounds such as caryophyllene oxide, isobornyl formate, and cumin aldehyde showed their highest amounts in the spring with the activation of some important plant enzymes such as peroxidase. The total content of flavonoids and some phenolic compounds (coumarin and p‐coumaric acid) increased when plants received sunlight for a longer time than in the colder to warmer seasons. On the other hand, increases in chlorogenic acid and vanillin were observed in spring. Also, the highest antioxidant activity was observed in lavender, which was accompanied by an increase in the important phenolic composition of rosmarinic acid in the cold season. Generally, this investigation provides beneficial evidence about the most appropriate harvest time for lavender to produce the most favorable constituents for optimization in food, pharmaceutical, and herbal products.
Contemporary diagnosis and management of severe tricuspid regurgitation
Authors: Zahr Firas , Chadderdon Scott , Song Howard , Sako Edward , Fuss Cristina , Bailey Steven R. , Cigarroa Joaquin
Published: September 2022

Many novel percutaneous interventions are being developed for application in the tricuspid valve position. At the present time in the United States, there are no commercially available transcathter devices for this application. This article reviews the growing evidence for diagnosing, imaging, and treating severe tricuspid regurgitation as well as the surgical and transcatheter options that are under current development and in various stages of clinical trials.
First case of sunflower pattern calcific deposits and posterior capsular opacification on a pseudophakos
Authors: Kaur Kirandeep , Mishra Snigdha , Gurnani Bharat
Published: September 2022

Calcification of the intraocular lens is an uncommon phenomenon that usually follows an uncomplicated surgery. Here, the authors report the first case of a 66‐year‐old male patient who presented with defective vision and was diagnosed with sunflower pattern calcific deposits and Elschnig pearl pattern posterior capsular opacification in the right eye.
Synergistic Electrocatalytic Syngas Production from Carbon Dioxide by Bi‐Metallic Atomically Dispersed Catalysts
Authors: Delafontaine Laurent , Murphy Eamonn , Guo Shengyuan , Liu Yuanchao , Asset Tristan , Huang Ying , Chen Jiazhe , Zenyuk Iryna V. , Pan Xiaoqing , Atanassov Plamen
Published: September 2022

The production of syngas by traditional processes such as steam methane reforming is energetically intensive and produces a large amount of CO2 emissions. In contrast, the electrochemical CO2 reduction reaction (CO2RR) enables the carbon neutral production of syngas at ambient conditions. Among non‐precious metal catalysts, metal‐nitrogen‐carbon electrocatalysts are inexpensive and highly selective towards syngas production. This study examined the selectivity of mono‐ and bi‐metallic (M−N−C, M=Fe, Mo or FeMo) electrocatalysts towards syngas production. The ratio of the CO : H2 in the syngas was tuned by modifying the ratio of the metallic precursors in the bi‐metallic FeMo−N−C catalysts, tailoring the catalysts’ selectivity towards the CO2RR or the hydrogen evolution reaction (HER). The catalyst synthesis temperature(s) were considered as they influence the catalyst morphology and activity. Further, the dependence of the ratio of CO : H2 in the syngas as a function of the potential was explored for the different bi‐metallic catalysts. This work showed that by tailoring both the ratio of Fe : Mo in the bi‐metallic catalyst and optimizing the reductive potential, a CO : H2 ratio between 0.25 to 5 was achievable. This study demonstrated a novel approach in which the ratio of the product syngas composition could be tailored in a single reaction, without the need for further downstream processing to reach a desired composition.
Piezoelectrically Mediated Reactions: From Catalytic Reactions to Organic Transformations
Authors: Ren Ziye , Peng Yuhao , He Hanliang , Ding Chengqiang , Wang Jialin , Wang Zhao , Zhang Zhengbiao
Published: September 2022

Comprehensive Summary

Recently, piezocatalysis has attracted considerable attention as a new type of renewable mechanical energy conversion technology, which relies on the strain induced polarization of the piezoelectric material. This new technology has been extensively applied in the applications of water splitting, water remediation, gas purification and tumor therapy. Despite the rapid development in the piezocatalysis, the utilization of piezoelectric materials for synthetic purpose is still under exploration. Piezoelectric means to promote organic reactions expand the scope of piezoelectrically mediated reactions and show successes in both organic and polymer synthesis. Herein, we provide a comprehensive review on recent progress of piezoelectrically mediated reactions, catalytic mechanisms and applications in the last few years. The limitations and future directions of this area are also discussed. We believe this review will provide new insights into the underlying mechanism of piezoelectric mediated electron transfer process and guide the design of new chemistry.
The Key Role of Subtle Substitution for a High‐Performance Ester‐Modified Oligothiophene‐Based Polymer Used in Photovoltaic Cells
Authors: Li Sunsun , Ding Yuan , Xu Lei , Zhao Wenchao , Zhang Jianqi , Qin Jinzhao , Zhang Yuyang , Zhao Jingjing , He Chang , Peng Qiming , Hou Jianhui
Published: September 2022

Comprehensive Summary

In organic solar cells (OSCs), developing high‐performing easily synthesized photoactive materials is essential for pursuing cost‐ effective balance. Herein, we have designed and synthesized a pair of wide‐band‐gap polymers (PBDE4T‐0F and PBDE4T‐2F), using the low synthesis cost dicarboxylic ester‐substituted quaterthiophene as the building block. Despite the minor change of molecular structure for polymer PBDE4T‐xF, the fluorine substituent in polymer PBDE4T‐2F greatly enhances its interchain aggregation. The higher aggregation tendency of ester‐modified polymer in solution is beneficial for reducing both the aggregate size and π‐π stacking distance of blend film, which contribute to the highly efficient exciton dissociation and symmetric charge transport. An impressive power‐conversion efficiency (PCE) of 16.1% is achieved for the PBDE4T‐2F:BTP‐eC9‐based device, while its counterpart only delivers a PCE of 5.8% with distinctly lower short‐circuit current density (Jsc) and fill factor. Notably, the aggregation effect of donor polymer has also been found to be associated with the energy level shifts, and thus the variation of charge transfer energy and voltage losses for blend system. The results suggest that simultaneously reduced voltage loss and increased Jsc can be expected by further finely tuning the aggregation behavior of the ester‐modified oligothiophene‐based donor polymer.
Kinetics of Catalyzed Thermal Degradation of Polylactide and Its Application as Sacrificial Templates†
Authors: Feng Li , Cui Chenhui , Li Zhen , Zhang Mengyuan , Gao Shenghui , Zhang Qiang , Wu Youshen , Ge Zhishen , Cheng Yilong , Zhang Yanfeng
Published: September 2022

Comprehensive Summary

Polylactide (PLA) is an outstanding sacrificial template material for the manufacture of microchannels in a thermosetting matrix. However, the initial thermal degradation temperature of pure PLA is relatively high (about 280°C), which limits its use as a sacrificial template. In this report, we found that TBD, an organic base catalyst, can significantly reduce the thermal degradation temperature of PLA. TBD has higher catalytic activity for the thermal degradation of PLA compared with Tin(II) oxalate (Sn(Oxa)), one catalyst reported in the literature. Moreover, the gaseous products catalyzed by TBD for PLA thermal degradation are mainly lactide, and the formation temperature of the monomer is lower and the yield is higher, which may have potential value for PLA recycling. A combined catalyst, S8T2, was composed of 80% low activity catalyst Sn(Oxa) and 20% high activity catalyst TBD, which can catalyze the rapid degradation of PLA without greatly damaging the mechanical properties of PLA. PLA‐S8T2 sacrificial fibers can form high‐precision one‐dimensional microchannels in the epoxy resin matrix, and 3D‐printed PLA‐S8T2 sacrificial templates can be used to form three‐dimensional microchannels in a thermosetting matrix by vaporization of sacrificial components process (VaSC). These features highlight the great potential of PLA‐S8T2 as sacrificial template material for the preparation of the complicated microchannels in the thermosetting matrix.
The role of coronary artery calcium in allocating pharmacotherapy for primary prevention of cardiovascular disease: The ABCs of CAC
Authors: Maniar Yash , Blumenthal Roger S. , Alfaddagh Abdulhamied
Published: September 2022

Determining optimal candidates for the numerous potential pharmacotherapies for primary prevention of atherosclerotic cardiovascular disease remains challenging. Selective use of coronary artery calcium (CAC) scoring is recommended by the 2018 and 2019 American Heart Association/American College of Cardiology Cholesterol and Primary Prevention Guidelines as a tool for refining cardiovascular disease risk assessment. A growing body of research shows that CAC has potential value in allocation of primary prevention aspirin, determining blood pressure targets and treatment intensity, the intensity of cholesterol management, and use of the more expensive medications for type 2 diabetes. We also review the literature regarding very elevated CAC scores greater than 400 or 1000 and how these scores appear to confer a risk for cardiovascular disease on par with secondary prevention cohorts.
Effect of Protonation and Deprotonation on Electron Transfer Mediated Decay and Interatomic Coulombic Decay
Authors: Kumar R. , Vaval N.
Published: September 2022

Electronically excited atoms or molecules in an environment are often subject to interatomic/intermolecular Coulombic decay (ICD) and/or electron transfer mediated decay (ETMD) mechanisms. A few of the numerous variables that can impact these non‐radiative decay mechanisms include bond distance, the number of nearby atoms or molecules, and the polarisation effect. In this paper, we have studied the effect of protonation and deprotonation on the ionization potential (IP), double ionization potential (DIP), and lifetime (or decay width) of the temporary bound state in these non‐radiative decay processes. We have chosen LiH‐NH3 and LiH‐H2O as test systems. The equation of motion coupled cluster singles and doubles method augmented by complex absorbing potential (CAP‐EOM‐CCSD) has been used in calculating the energetic position of the decaying state and the system's decay rate. Deprotonation of LiH‐NH3/LiH‐H2O either from the metal center (LiH) or from ammonia/water lowers the IP and DIP compared to the neutral systems. In contrast, protonation increases these quantities compared to neutral systems. The protonation closes the inner valence state relaxation channels for ICD/ETMD. For example, the decay of the O‐2s/N‐2s state stops in protonated systems (LiH2+‐H2O, LiH2+‐NH3, and LiH‐NH4+). Our study also shows that the efficiency, i. e., the rate of ICD/ETMD, can be altered by protonation and deprotonation. It is expected to have implications for chemical and biological systems.
Recovery of High Concentrations of Phosphorus and Ammonium through Struvite Crystallization by CO2 Repelling
Authors: Korchef Atef , Naffouti Saoussen , Souid Imen
Published: September 2022

Struvite (MgNH4PO4·6H2O) can precipitate from wastewater thereby recovering both ammonium and phosphorus while simultaneously producing a valuable fertilizer. In the present work, the precipitation of struvite by CO2 repelling at initial constituent ions concentrations in the range between 123.89 and 800 mg L−1 and different airflow rates is investigated. Struvite precipitation is induced by an increase of the solution supersaturation occurring concurrently with the removal of the dissolved CO2 from the solution. The precipitates obtained are characterized by powder X‐ray diffraction and scanning electronic microscopy. For all experiments, struvite is the only phase observed. Whatever the airflow used, the precipitation pH decreases with increasing the initial phosphorus concentration. Struvite precipitates at supersaturations in the range 6–18 and pH in the range 6.5–8.5. High phosphorus removal efficiencies (>70%) are obtained at high struvite supersaturations. The increase in the airflow rate results in a significant decrease in the phosphorus removal efficiency. When the initial phosphorus concentration increases, the particle size distribution becomes monomodal covering a broad range of particle sizes up to 140 µm. This is of utmost importance since larger struvite crystals are easier to separate from the liquid phase and release ammonium and phosphorus from struvite faster, promoting the use of struvite as a fertilizer.
Early selection for spike fertility index increases yield of advanced generations in bread wheat
Authors: Alonso María Pía , Franco María Fiorella , Pontaroli Ana Clara Clara
Published: September 2022

Spike fertility index (also known as fruiting efficiency) at maturity (FEm: grain number per spike g–1 spike chaff at maturity) and spike harvest index (SHI: grain weight per spike g–1 spike chaff weight at maturity) are considered promising selection criteria for improving grain yield (GY) in bread wheat (Triticum aestivum L.). However, their usefulness in early generations remains to be established. Here, a population derived from a cross between ‘Baguette 10’ and ‘Klein Chajá’ was evaluated from early generations (F2–F3) to recombinant inbred lines (RIL). Associations of FEm and SHI measurements between early generations and RIL were established. Also, responses in grain number m–2 (GN) and GY in the RIL after simulated selection for high FEm or high SHI in the F2–F3 were assessed. Positive correlations were found in FEm measured in the F2–F3 vs. in the RIL (r = .32, P < .05) and SHI measured in the F3 vs. in the RIL (r = .26, P < .05). After selection for high FEm in the F2–F3, responses in GN were always positive: GN increased by 5.1–22.1% depending on the selection strategy. Responses in GY were positive in three out of four selection strategies, averaging –1.3–2.1%. Responses to selection in GN and GY in the RIL using SHI as a selection criterion in the F2–F3 were negative or neutral. Our results support the use of FEm as a selection criterion in early generations for increasing GN and GY in advanced generations of bread wheat‐breeding programs.
Curriculum as mindfully lived in relationships
Authors: Hunter‐Lynch Hannah , Kimblern Denise , Sexton Danny , Wang Hongyu
Published: September 2022

In the context of the COVID‐19 pandemic, this co‐authored paper grew out of a graduate course on mindfulness and an extended inquiry into what it means to cultivate mindful relationships in curriculum as lived experience. Centring three graduate students' experiential projects, including two projects of interactions with nature and one project of interpersonal interactions, this paper demonstrates the process of practicing mindfulness from students' perspectives as individual inquiry, a process that was filled with curves and frustrations as well as revelations and potentiality. The teacher educator created pedagogical conditions but the students enacted their own curriculum in their lived experience of forming mindful relationships. A further layer of inquiry was conducted in the conversations among the three graduate students and the teacher educator, from which shared meanings of time, self‐understanding, gender and making connections across difference emerged. A reconstructed conversation was composed to demonstrate this inquiry process. Curriculum as lived experience, including curriculum as a complicated conversation, is the orientation for this individual and group inquiry. This study shows that curriculum as mindfully lived in relationship is an emergent process of cultivating both deepened self‐understanding and relational attunement, sustained through a lived body, lived time and space, and lived connections across difference.
Molecular/biomarker testing in lung cytology: A practical approach
Authors: Schmitt Fernando , Lozano Maria D.
Published: September 2022

The increasing comprehension of molecular mechanisms underlying lung cancer and the discovery of targetable genomic alterations has dramatically change the pathological approach to lung cancer, especially non‐small cell lung cancer (NSCLC). This unstoppable knowledge has taken pathologists to the leading front on lung cancer management. This is especially relevant in the world of cytopathology where “doing more with less” is a daily challenge. Nowadays with a growing number of predictive biomarkers needed to manage patients with NSCLC, there has been a paradigm shift in care and handling of diagnostic samples. One of the main emphasis and interest relies on the utilization of cytologic samples and small biopsies for not only diagnostic purposes but also for ancillary testing. Moreover, lung cytopathology is in continuous evolutions with implementation of new diagnostic techniques, new tools, and facing new challenges. The goal of this paper will be to provide the reader with the necessary concepts than can be used to exploit the cytological samples in order to use these samples for comprehensive diagnosis and relevant ancillary testing purposes.