bluuebunny/crossref_metadata_2025 huggingface dataset:
Patients with Patellofemoral Pain Exhibiting Decrease Vertical Ground Reaction Force Compared to Healthy Individuals during Weight Bearing Tasks: A Systematic Reviews and Meta-Analysis
Authors: Yalfani Ali , Ahmadi Mohamadreza
Published: February 2023

Background: Vertical ground reaction force (VGRF) can lead to the development knee osteoarthritis. This review systematic and meta-analysis aimed to investigate the VGRF in patellofemoral pain patients (PFP) during weight bearing tasks.
Methods: Search strategy was conducted in databases: Science Direct, Scopus, PubMed and Google Scholar from Sep 2020 to Jun 2021. The VGRF components we measured were passive impact (Fz1)/peak and propulsion/active peak (Fz2). The quality of the studies was evaluated with Down and Black index and it was divided into three groups: low quality (LQ), medium quality (MQ) and high quality (HQ). The standardized mean difference between PFP and healthy individuals was used to calculate the effect size.
Results: Nine articles were selected for systematic review and meta-analysis of which 5 studies was HQ, 3 studies were MQ and 1 study was LQ were classified. PFP compared to healthy individuals with moderate and small effect size have reduced impact and propulsion respectively. 
Conclusion: The in PFP, VGRF is influenced psychological, behavioral and biomechanical factors. Therefore, psychosomatic therapeutic approaches may have a long time effectiveness on the rehabilitation of PFP.
Health System Governance Evaluation: A Scoping Review
Authors: Farough Khosravi Mohammad , Mosadeghrad Ali Mohammad , Arab Mohammad
Published: February 2023

Background: Governance is one of the critical functions of the health system. Good governance of the health system leads to better performance and outcomes. Evaluation is the first step to improving health system governance. Therefore, this research aimed to identify evaluation tools for health system governance.
Methods: In the current scoping review, we searched all documents related to health system governance evaluation indexed in Medline, EMBASE, ProQuest, Scopus, Cochrane Library, Science Direct databases, and Google Scholar search engines to 2022, extracted, and assessed. Finally, documents were selected and analyzed by thematic analysis.
Results: Thirty tools were found to evaluate health system governance. Among the proposed tools, 11 specific tools have been designed just for health system governance evaluation, while others have governance as a component of health system evaluation. Health system governance’s significant components are health policy-making, strategic planning, organizing, stewardship, and control. Indicators such as accountability, participation, transparency, equity, efficiency, accountability, corruption control, effectiveness, ethic, the rule of law, and sustainability could be used to evaluate the health system governance. 
Conclusion: Different tools have been used to evaluate governance worldwide, and each governance evaluation tool has different components suitable for governance evaluation. However, these tools cannot fully evaluate governance and have shortcomings. A comprehensive evaluation of governance and sharing lessons denrael will affect the health system's capacity and ability to provide quality, safe and effective health services. It will lead to the stability of the health system.
Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein
Authors: Zeng Xiangyue , Yang Xinhui , Parhatsayim Shayim , Abudoukelimu Abulajiang , Shu Yin , Zhao Zeliang
Published: February 2023

Background: Colorectal cancer is the third most common malignant tumor in the world and substantial death cases are reported each year. We aimed to explore the molecular mechanism underlying colorectal cancer tumorigenesis and progression.
Methods: The expression levels of Forkhead box A2 (FOXA2) in colorectal cancer tissues were first analyzed using Gene Expression Profiling Interactive Analysis (GEPIA). More multiple in vitro experiments established the role of FOXA2 in colorectal cancer progression. The potential downstream target of FOXA2 was identified by Western blot analysis.
Results: FOXA2 expression level was significantly up-modulated in colorectal cancer specimens and cells (P<0.05). Silencing FOXA2 remarkably inhibited colorectal cancer cells growth, invasion and migration. BCL2-associated X (BAX) protein was identified as a potential downstream protein of FOXA2.
Conclusion: Our findings demonstrated the essential role of FOXA2 in colorectal cancer progression and identified BAX protein as its potential target.
Evaluation of Preventive Health Practices in Turkey
Authors: Çakir Mustafa
Published: February 2023

Background: Although preventive health practices are extremely effective in preventing diseases and mortality, there is still a need to determine the frequency of these practices in different countries and improve these rates. The aim of this study was to evaluate preventive health practices in Turkey.
Methods: The study was designed as a cross-sectional research. The study was conducted by utilizing the “Turkey Health Survey 2019” microdata set from the Turkish Statistical Institute. The data of 17,084 people aged 15 years and over were evaluated.
Results: Approximately 54.4% of the participants were women, 24.5% were 15–29 years old, and 21.0% were 60 years of age or older. Approximately 51.2% of the participants stated that their general health status as good. 2.3% of the participants had taken the flu vaccine in the last year, 38% of people aged 50–70 years had undergone a fecal occult blood test in the last 5 years, 32% of women aged 40–69 years had undergone mammography/breast X-ray in the last 2 years, and 44% of women aged 30–65 years had undergone a cervical swab test in the last 5 years.
Conclusion: Although the rate of public participation in cancer screenings in Turkey is considerable, the data show that the rates should be further increased. In contrast, flu vaccination frequency is considerably low. To increase the frequency of preventive health practices, Turkish public should be informed about these practices, where they can be performed, and their importance.
Effect of Psychological Counseling Based on Problem Management Plus on Social Anxiety in Parents of Children with Autism Spectrum Disorder
Authors: Qi Aili , Wang Fatao , Cao Tiwang
Published: February 2023

Background: Autism spectrum disorder (ASD) is a widespread mental growth disorder. Children with ASD are unlikely to restore the ability of living independent, which definitely brings their parents greater psychological pressure and psychological problems such as social anxiety. Therefore, it is pressing to conduct intervention research on social anxiety and other problems in parents of children with ASD. 
Methods: In 2022, Seventy-three parents of children with ASD were enrolled from Beijing Tongkangyuan Children's Rehabilitation Institute. They were randomly divided into the experiment group (N=36) and the control group (N=37). The experiment group was intervened with psychological counseling based on problem management plus in combination with Tai Chi. The control group did not receive any psychological intervention. Social Anxiety Scale for Children, Parenting Stress Index-Short Form and Social Support Rate Scale were used for measurement before and after the intervention.
Results: The experiment group had significantly higher decreases than the control group in the total score in social anxiety and the scores in its two dimensions after intervention (P=0.001). The experiment group had significant decreases in the total score in parenting stress and the scores in parenting distress and dysfunctional parent-child interaction (P=0.001), while there was no change in the control group. The experiment group had significant improvement in social support, which was also significantly higher than that of the control group (P=0.001).
Conclusion: Psychological counseling based on problem management plus could effectively alleviate social anxiety and parental pressure in parents of children with ASD, improve their social support and play a significant role in enhancing their mental health.
Effects of Antenatal Lifestyle Interventions in Pregnant Women with Normal Body Mass Index
Authors: Yang Hong , Zhao Yun , Tu Jiahui , Chang Yanan , Xiao Chanyun
Published: February 2023

Background: We aimed to explore the effect of lifestyle interventions on improving lifestyle behaviors on gestational weight gain in pregnant women with normal body mass index (BMI).
Methods: The study was conducted in Maternal and Child Health Hospital of Hubei Province (Wuhan, China) between June 2020 and April 2022. A total of 355 pregnant women (<12 weeks of pregnancy) were enrolled and finally completed the program. Participants were divided into the intervention and control groups. The intervention group received an individualized lifestyle intervention focusing on healthy lifestyle, like diet, exercise, and weight monitoring as four sessions at 16–18, 20–24, 28-30 and 34 weeks’ gestation. Participants in the control group received routine antenatal care. The weight of both group was recorded from pregnancy until 6-8 weeks postpartum.
Results: The participants in the intervention group with normal pre-pregnancy BMI (n = 178) had lower GWG, excessive GWG, hypertension, and neonate birth weight compared to the control group (n = 177, P< 0.01). There were no statistically significant differences in the occurrence of gestational diabetes, premature labor, delivery mode, preterm birth, small for gestational age, macrosomia, number of neonates referred to the NICU, and postpartum weight retention.
Conclusion: Even though lifestyle intervention in pregnant women with normal BMI has a relatively limited effect, attention should still be paid to reasonable weight gain during pregnancy and the potential long-term impact of the intervention remains to be assessed.
Different Aspects of Mercury Poisoning in Children
Authors: Melek Oguz Melahat , Acoglu Esma Altinel , Oztek Celebi Fatma Zehra , Polat Emine , Yucel Husniye , Sahin Sanliay , Akcaboy Meltem , Senel Saliha
Published: February 2023

The Article Abstract is not available.
Metoda etnogeograficzna w ukazywaniu zróżnicowania kulturowego w mikroskali. Przykład pożywienia wigilijnego na Śląsku Cieszyńskim
Authors: Księżnik Kamilla
Published: February 2023

Celem artykułu jest pierwsza próba przybliżenia możliwości wykorzystania metody etnogeograficznej do ukazywania zróżnicowania kulturowego w mikroskali (przykład Śląska Cieszyńskiego). W tekście przybliżono m.in. specyfikę metody etnogeograficznej, stan dotychczasowych badań Polskiego Atlasu Etnograficznego nad pożywieniem ludowym (w tym wigilijnym), ogólny kontekst świętowania wigilii Bożego Narodzenia na Śląsku Cieszyńskim. Szerzej skupiono się jednak na próbie przedstawienia zróżnicowania kulturowego kilkunastu wsi Śląska Cieszyńskiego na początku XXI w. na dziewięciu mapach etnogeograficznych, po raz pierwszy opracowanych w mikroskali (regionalnej). Autorka stawia jednocześnie następujące pytania: 1) Czy potrawy wigilijne podawane w badanych wsiach na początku XXI w. zachowują specyfikę kulturową Śląska Cieszyńskiego?; 2) Czy omawiane wsie są jednorodne pod względem kulturowym, czy może wyróżniają się na tle pozostałych?; 3) Czy za pomocą metody etnogeograficznej można ukazać zróżnicowanie kulturowe na mniej rozległych obszarach?
Uwarunkowania rozwoju gospodarczego rosyjskiego Dalekiego Wschodu
Authors: Duraj Natasza
Published: February 2023

Zasadniczym celem monografii jest przedstawienie problematyki, dotyczącej rozwoju gospodarczego rosyjskiego Dalekiego Wschodu. Monografia adresowana jest dla szerokiego kręgu odbiorców, interesujących się problematyką rozwoju gospodarczego Rosji i rosyjskiego Dalekiego Wschodu.
“GOTCHUU!”: THE USE OF SLANG IN SOCIAL MEDIA BY GENERATION Z
Authors: Yusuf Yunisrina Qismullah , Fata Ika Apriani , Aini Rahimatul
Published: February 2023

Slang has received much attention in research on analysis in recent years. Many studies found that slang dominated media, film, and novels. Similarly, studies on English slang received higher interest than other languages. The present study, in contrast, analyzes the slang used by Indonesian Generation Z in WhatsApp groups. The research is a qualitative study, with the researcher's primary focus in data collection being content analysis. Based on Allan and Burridge's (2006) theory, the researcher discovered 50 slang classified into seven functions: starting a relaxed conversation (27 occurrences), expressing an impression (12 occurrences), creating an intimate atmosphere (5 occurrences), addressing (3 occurrences), abusing others (3 occurrences), humiliating (0 occurrences), and expressing intimacy (0 occurrences). Furthermore, those are divided into five types: fresh and creative (7 occurrences), flippant (9 occurrences), imitative (12 occurrences), acronym (14 occurrences), and clipping (14 occurrences) (8 occurrences). In conclusion, Generation Z has used this slang to increase the intimacy of their daily WhatsApp conversations.
THE PERSONIFICATION OF FIGURATIVE WORDS IN TRUBUS MAGAZINE: A MODERN STYLISTICS STUDY
Authors: Imrotin Imrotin , Badrih Moh. , Famsah Saefuddin , Busri Hasan
Published: February 2023

Personification is one of the figurative languages used in casual and academic texts. One of the popular magazines that employs figurative language to attract readers is Trubus. The current study aims to analyze the classification, structure, rhyme words, lexical meaning, and imagery styles of personification in Trubus magazine. It is descriptive qualitative research using the Metaphor Identification Procedure (MIP) approach. The data source in this study is Trubus magazine, edition 2021. Data analysis covers the personification of figurative language's reduction, assessment, and inference. The result found that the personification style in this magazine belongs to inanimate objects, which tend to be abstract. Meanwhile, the rhyme words employ the beauty of the alliteration sound at the beginning of the word. Further, the grammatical structure is general. Lastly, grammatical, textual, and contextual fields contribute to meaning-making.
Quality of work life, work motivation, job satisfaction and ethical behaviour
Authors: Ononye Uzoma
Published: February 2023

Ethical behaviour ensures employees follow organisational social norms in the conduct of their tasks and assignments. But studies have been somewhat silent on the individual-level factors influencing this positive work behaviour, especially in an African public sector context. Further, the contextual factors impacting ethical behaviour at work are yet to be fully known. Therefore, the study examined the relationship between quality of work life and work motivation on ethical behaviour given job satisfaction as a contextual factor. The study collected data from 191 mid-level employees in the Delta State Ministry of Health in Nigeria, and subjected same data to the PLS-SEM analytical procedure. The results demonstrated that job satisfaction and ethical behaviour are positively related, job satisfaction mediates quality of work life and work motivation relationship with ethical behaviour, and quality of work life relationship with ethical behaviour is mediated by work motivation and job satisfaction sequentially. The study concluded that the link between quality of work life and work motivation on ethical behaviour can be explained by the mediational mechanism of job satisfaction. The results imply that public organisations can support ethical behaviour when certain individual-level (psychological) factors are well positioned and managed to achieve desirable outcomes.
Impact of working capital management on profitability of Industrial sector in Iraq
Authors: Ibrahim Sardar Shaket
Published: February 2023

This paper observes the impact of working capital management on profitability of industrial sector in Iraq. Four companies based in Iraq namely: Iraqi Date processing, Iraqi carton manufactories, Baghdad soft drinks and Iraqi for tufted carpets randomly selected and analyzed for the present study over the period 2007 to 2016.  Annual reports of these companies have been studied and significant ratios calculated. The variables that were identified as independent for working capital were, current ratio and quick ratio, while return on equity ROE as dependent variable for profitability. The Ordinary Least Square (OLS) model used to examine the impact of working capital management on profitability. Results indicate that ROE is positively related with working capital variables.
The Convergence of Beta Credit for Micro, Small and Medium Enterprises (MSMEs) in Indonesia’s Provinces
Authors: Suidarma I Mada , Sara I Mada , Anggaradana I Nyoman , Pratiwi I Gusti Ayu Made Agung Andirani
Published: February 2023

The success of SMEs is determined by the business capital and able to give value added to the business more productively. Various financing pattern schemes for SMEs have been provided in various regions and all economic sectors. However, the development of SMEs credit is still concentrated in several regions in Indonesia this can lead to inequality in the growth of SMEs. This study aims to analyze the convergence of absolute beta and conditional beta in the Provinces in Indonesia and calculate the half-time or time required to achieve steady-state conditions of the SME credit convergence process. Convergence test used is beta conditional convergence and absolute convergence with the monthly time period during 2017.1 until 2017.7. The determinant of SMEs convergence of credit in Indonesia is a number of third-party funds. The model used is dynamic panel data regression and the estimation method used is Arellano-Bond Generalized Method of Moment (AB-GMM). The results of the study show that during the study period, there has been a convergence credit process in Indonesia for both absolute and conditional convergence models. The conditional beta-convergence model provides a smaller beta value than the absolute model. The speed of credit growth convergence between provinces in Indonesia with half-time of 6.94 months for the absolute model and the half-time of 6.96 months for the conditional model
“EU QUERO IR PRA CASA”
Authors: Soares Layane Campos , Resende Ottoni Maria Aparecida
Published: February 2023

Neste artigo, realizamos uma análise discursiva do documentário “Eu quero ir pra casa”, com o intuito de investigar como os jovens que participam dessa produção audiovisual se identificam e como são identificados nas diferentes narrativas e quais recursos lexicogramaticais realizam essas identificações. Para realizar a análise, pautamo-nos em estudos sobre o Sistema da Avaliatividade (MARTIN; WHITE, 2000; MARTIN; ROSE, 2003; WHITE, 2004; MARTIN; WHITE, 2005). Os resultados principais revelam que os jovens se identificam e são identificados por meio de escolhas lexicogramaticais tais como: perdido, revoltado, triste, isolado, maltratado, dentre outras, que denotam avaliações de Afeto e de Julgamento.
A TRANSITIVIDADE NA REPRESENTAÇÃO DO TRABALHO DE MÉDICOS QUE ATUARAM NA PANDEMIA DA COVID-19
Authors: Espindola Elaine , Gouveia Kelly Aparecida Almeida , Marinho José Eric da Paixão , Oliveira Tammara
Published: February 2023

Estudos da linguagem que versam sobre o contexto pandêmico que vivemos são essenciais para entendermos como atividades foram realizadas/ impactadas. Utilizando-se da Linguística Sistêmico-Funcional (LSF), esta pesquisa considera que a linguagem sofre influências do contexto de produção e dos objetivos esperados. Assim, este estudo tem como objetivo mapear e compreender quais processos representam as experiências dos médicos ao discorrerem sobre as suas atividades profissionais no decorrer da pandemia. Os resultados confirmam que os participantes utilizaram com maior frequência processos mentais e relacionais para caracterizar os efeitos da pandemia nas suas atividades profissionais e nas suas relações interpessoais.
ENSINO DE INGLÊS DENTRO DE UMA PERSPECTIVA FUNCIONAL
Authors: Andrade de Souza Sheilla
Published: February 2023

Este artigo é recorte de uma tese desenvolvida no Programa de Pós-Graduação em Estudos de Linguagens do Centro Federal de Educação Tecnológica de Minas Gerais. Objetiva apresentar o desenvolvimento de uma proposta de ensino e de pesquisa baseados na pedagogia do gênero. As atividades foram amparadas em uma perspectiva funcional de uso de língua e de linguagem. Considerou que outros modos de signifcação precisam ser trabalhados em sala de aula, não somente o verbal. Partiu do princípio de que todo texto é multimodal (Kress, 2010), isto é, formado por mais de um modo de significação. Como metodologia usou-se a pesquisa participante. Os dados foram coletados por meio de questionários, entrevista, notas de campo. Como resultado, percebeu-se que o foco da atividade foi além do ensino da língua como estrutura e favoreceu o desenvolvimento de outras capacidades e conhecimentos dos alunos. Houve superação das dificuldades e o trabalho com base em gêneros textuais permitiu o uso da língua em situações reais de comunicação.
DOIS TIMORES
Authors: Rezende da Silva Silveira Leiliane , Almeida Pedra Lorena , Oliveira Thiago Soares de
Published: February 2023

Em 2000, a Universidade Nacional Timor Lorosa’e, primeira universidade pública do Timor, foi criada através da fusão do ensino técnico superior e o acadêmico. Assim, este trabalho objetiva refletir acerca do duplo cenário histórico-universitário em Timor: o que foi instaurado durante o domínio indonésio e o que foi implementado ao final dele, pontuando, a emergência do ensino de português. Como resultado, pode-se apontar a passagem do ensino privado para o público, a integração de timorenses aos cursos universitários e os convênios firmados com instituições de diversos países, levando à internacionalização da educação no país e à manutenção do português.
A Comparative study of Lexicon based and Machine learning based Classifications in Sentiment analysis
Authors:   Research Scholar and Assistant Professor, PG and Research Department of Computer Science, Mr M. Muthuraman , Mr S. Ravichandran ,   Assistant Professor and Head, PG and Research Department of Computer Science, H.H. The Rajah’s College
Published: February 2023

Internet and WWW are growing a huge amount of data from the users entered the text that is related to the product review, opinions, attitudes, and any other services. This information is processing and analyzing various tools to be used. The NLP and Information retrieval methods are used to analyze the information and understanding these process information. The main problem of Sentiment analysis is classified into two categories that are Positive opinion or negative opinion. This paper focus to compare the lexical based sentiment classification and Machine learning based sentiment classification methods. Various algorithms and approaches and features are classified in this paper. Different methods are taken to solve the sentiment analysis problems.
Application of Utility Mining using Frequent Itemset and Association Rules: A Survey
Authors:   Research Scholar, PG and Research Department of Computer Science, D. G. Vaishnav College, Arumbakkam, Chennai, India, Ms T.Indhumathy , Mr T.Velmurugan ,   Associate ProfessorPG and Research Department of Computer Science, D. G. Vaishnav College, Arumbakkam, Chennai, India
Published: February 2023

Mining on data reveals patterns that provide useful information for analysis, decision making and forecasting in various domains. Association Rule Mining (ARM) identifies patterns on itemsets which are either frequent or have interesting relationship amongst them based on strong rules and conceptually form a basis for Frequent Itemset mining (FIM) problems. FIM extracts binary values from transaction databases to identify frequently bought items but provides insufficient information for identifying infrequent items that generate maximum profit. So a latter problem, High utility itemsets (HUI) mining was developed to focus on the itemsets that generate huge profit to the business. Even though HUI is related to Business Intelligence, its application extends to Web Server Logs, Biological Gene Databases, Network Traffic Measurements and many other fields. This paper presents a survey on the algorithms from different aspects and perspectives based on Utility mining, Frequent Itemset generation and Association Rule Mining
Popular Influenza Antiviral Drugs: Mechanisms, Efficacy, and Resistance
Authors: Ley Sidney
Published: February 2023

Influenza viruses cause acute respiratory infections responsible for significant mortality and morbidity around the world. Because factors such as antigenic drift allow influenza strains to avoid being fully suppressed by seasonal vaccines, public interest has led to increased scrutiny of antivirals as treatment and prophylaxis options for seasonal outbreaks and potential pandemics. Unfortunately, many influenza antivirals suffer from a lack of sufficient clinical trials, as well as a lack of toxicity data; this is especially true of umifenovir (Arbidol), a popularly used drug for the prevention and treatment of influenza strains in China and Russia. Neuraminidase inhibitors, though widely prescribed, display a potential for future resistance. Adamantanes, while proven to be effective in treating influenza A, are already encountering rapid, widespread cross-resistance, and are effectively obsolete. Baloxavir marboxil, a newer antiviral, shows promise in treating acute uncomplicated influenza and may avoid the development of resistance when coadministered with other antiviral drugs. Indeed, the low genetic barriers to resistance faced by influenza antivirals may be surmounted by coadministration with other antivirals. This review explores the most widely prescribed antivirals for influenza treatment, their mechanisms of action, and current data on their susceptibility to resistance and efficacy at this time.
Influence of Morphological Parameters on the Flow Development Within Human Airways
Authors: Espinosa-Moreno A.S. , Duque-Daza C.A. , Garzón-Alvarado D.A.
Published: February 2023

Anatomical airways parameters as length, diameter and angles have a strong effect on the flow dynamics. Aiming to explore the effect of variations of the bifurcation angle (BA) and carina rounding radius (CRR) of lower human airways on the respiratory processes, numerical simulations of airflow during inhalation and exhalation were performed using a synthetic bifurcation models. Geometries for the airways models were parameterized based on a set of different BA's and several CRR's. A range of Reynolds numbers (\Reyn) relevant to the human breathing process were selected to analyzed the airflow behaviour. The numerical results show a significant influence of BA and the CRR on the development of the airflow within the airways, and therefore affecting some relevant features of the flow, namely the deformation of velocity profiles, alterations of pressure drop, the flow patterns, and finally enhance or attenuation of wall shear stresses (WSS) appearing during the regular respiratory process. Numerical results show that increases in the bifurcation angle value are accompanied by pressure increases of about 20\%, especially in the regions close to the bifurcation. Similarly, increases in the BA value lead to a reduction in peak shear stresses of up to 70\%. For the ranges of angles and radii explored, an increase in pressure of about 20\% and a reduction in wall shear stress of more than 400\% were obtained by increasing the carina rounding radius. Analysis of the coherent structures and secondary flow patterns also revealed a direct relationship between the location of the vortical structures, the local maxima of the velocity profiles and the local vorticity minima. This relationship was observed for all branches analysed, for both the inhalation and exhalation processes of the respiratory cycle.
Two Grey–White Matter Circuits Separate Borderline Personality Disorder From Controls and Mediate the Relationship Between Specific Childhood Traumas and Symptoms. A mCCA+jICA and Random Forest Approach
Authors: Grecucci Alessandro , Dadomo Harold , Salvato Gerardo , Lapomarda Gaia , Sorella Sara , Messina Irene
Published: February 2023

Borderline Personality Disorder (BPD) is a severe personality disorder whose neural bases are still unclear. Indeed, previous studies reported inconsistent findings concerning alterations in cortical and subcortical areas. In the present study we applied for the first time an unsupervised machine learning approach known as mCCA+jICA, in combination with a supervised machine learning approach known as Random Forest, to possibly find covarying GM-WM circuits that separate BPD from controls and that are also predictive of this diagnosis. To this aim, we analyzed the structural images of patients with BPD and matched HCs. Results showed that two GM-WM covarying circuits, including basal ganglia, amygdala, and portions of the temporal lobes and of the orbitofrontal cortex, correctly classified BPD against HC. Notably, these circuits are affected by specific child traumatic experiences (emotional and physical neglect, and physical abuse) and predict symptoms severity in the interpersonal and impulsivity domains. These results support that BPD is characterized by anomalies in GM and WM circuits related to early traumatic experiences and specific symptoms.
Determination of Composition of Raw Materials for Porcelain Fabrication by XRF, TOF-SIMS, and XPS Methods for Further Porcelain Art Items Characterisation and Detection of Modern Counterfeits
Authors: Wainstein Dmitry , Vakhrushev Vladimir , Kovalev Anatoly , Konovalov Egor , Volkov Anton , Shipova Maria
Published: February 2023

Modern surface analysis techniques are expanding significantly possibilities in description and attribution of historical artifacts. The present study is aimed to compare analytical ability of the X-ray fluorescent analysis (XRF) typically applied for studies ceramic art items with novel surface analysis methods: time-of-flight secondary ions mass spectroscopy (SIMS) and X-ray photoelectron spectroscopy (XPS) that were applied on measurements of elemental compositions of powder raw materials for porcelain fabrication: pegmatite P-1, Vesco-prima clay, kaolin, bone earth, dolomite, and feldspar. It was shown that SIMS successfully measures light elements unnoticeable for XRF such as lithium, beryllium, boron and heavy impurities not found out by XRF such as cobalt, cerium, copper, rubidium, vanadium. XPS has found thorium in the kaolin sample that was not detected by SIMS and XRF. The paper provides also values of chemical shifts of some XPS lines observed in materials under examination. The obtained information on relations of basic and impurity elements revealed by XRF and SIMS together with XPS chemical shifts data could be used to expose contemporary falsifications of historical porcelain and to attribute porcelain items during conservation process.
Overview and New Insights into the Metabolic Syndrome: Risk Factors and Emerging Variables in the Development of Type 2 Diabetes and Cerebrocardiovascular Disease
Authors: Hayden Melvin R.
Published: February 2023

Abstract Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily increasing globally and seems to parallel the increasing prevalence of obesity. It consists of a cluster of risk factors, which traditionally includes obesity and hyperlipidemia, hyperinsulinemia, hypertension, and hyperglycemia. These four core risk factors are associated with insulin resistance (IR) and importantly, the MetS is known to increase the risk for developing cerebrocardiovascular disease and type 2 diabetes mellitus. The MetS had its early origins in IR and syndrome X. It has undergone numerous name changes with additional risk factors and variables being added over the years; however, it still remains the MetS worldwide for the past three decades. This overview continues to add novel insights to the MetS and suggests that leptin resistance with hyperleptinemia, aberrant mitochondrial stress and reactive oxygen species (ROS), impaired folate-mediated one-carbon metabolism with hyperhomocysteinemia, vascular stiffening, microalbuminuria, and visceral adipose tissues extracellular vesicle exosomes be added to the list of associated variables. Notably, the role of a dysfunctional and activated endothelium and deficient nitric oxide bioavailability along with a dysfunctional and attenuated endothelial glycocalyx, vascular inflammation, systemic metainflammation, and the important role ROS and reactive species interactome are discussed. With new insights and knowledge regarding the MetS, comes the possibility of new findings through further research.
Relationship between Skeletal Muscle and Physical Activity in 4- to 6-year-olds
Authors: Pengyu Deng , Hayao Ozaki , Toshiharu Natsume , Yoshihiko Ishihara , Dandan Ke , Koya Suzuki , Hisashi Naito
Published: February 2023

Purpose: Physical activity (PA) is likely the most important modifiable element for the growth of skeletal muscle. However, a detailed investigation of PA’s impact on preschoolers’ of skeletal muscle development is lacking. This study aimed to determine whether PA level is related to skeletal muscle thickness among preschool children. Methods: 275 healthy preschoolers between the ages 4–6 were instructed to wear an accelerometer for 4 consecutive days. The daily steps and minutes spent in moderate-to-vigorous PA (MVPA) and total PA (TPA) were examined. Muscle thickness (MT) was measured by B-mode ultrasonography. The MT was measured at the anterior (AT) and posterior thigh (PT) and the anterior (AL) and posterior lower leg (PL). Results: Boys were more physically active and engaged in significantly more TPA and MVPA on weekdays compared with girls. Compared with that on the weekends, more physical activity, and significantly greater number of daily steps and higher TPA and MVPA were recorded for both boys and girls on the weekdays. Multivariable regression analyses, after adjusting for daylight duration, indicated that a daily increase in the TPA and MVPA would lead to higher muscle size in AT (β=1.11 and β=1.37, p<0.05), and PL (β=1.18 and β=0.94, p<0.05) among preschool children. Conclusions: The time spent involved in most of the different categories of MVPA was significantly higher for boys than for girls on the weekdays and weekends. MVPA was positively correlated with greater skeletal muscle development in the lower body.
A Glimpse of Ocean of Abundant Discoveries: Two-Way Cross Family Analysis of In-Silico Ranked 2nd Order Unexplored, ETC-1922159 Affected, Synergistic Combinations in CRC Cells
Authors: Sinha Shriprakash
Published: February 2023

Often, in biology, we are faced with the problem of exploring relevant unknown biological hypotheses in the form of myriads of combination of factors that might be affecting the pathway under certain conditions. For example, Brancati et al.1 observe that mutations in poliovirus receptor related protein 4 (PVRL4), encoding cell adhesion molecule nectin-4, causes Ectodermal dysplasia-syndactyly syndrome. Interaction with cad- herins also implies an influence of nectin-4 on Wnt signaling, which plays a relevant role in limb development (Brancati et al.1). However, not much work has been done to explore the relation of Wnts and PVR family. In CRC cells treated with ETC-1922159, both were found up regulated. In a recent unpublished work in Open Science Framework, Sinha2, we had the opportunity to rank these unknown biological hypotheses for both up and down regulated genes at 2nd order level after drug administration. The search engine alloted high nu- merical valued rankings to some combinations of PVR-WNT, thus indicating a possibility of high combinatorial synergy also. The in-silico derived influences can be represented graphically as - PVR w.r.t WNT with PVR <- WNT9A; and WNT w.r.t PVR with WNT-7B/9A <- PVR and WNT4 <- PVRL2; In the light of the recent findings of PVR with IFN (interferon) and the known interactions between IFN and Wnts, there might be a possibilty to explore the bridge of PVR, IFN and WNTs. The 3 fold (PVR - IFN; IFN - WNT; WNT - PVR), 2 way cross family analysis might shed light on the possible combinations that might be of import. Here, we present a 2-way cross family analysis of multiple, such in-silico ranked 2nd order synergistic combinations, after ETC-1922159 treatment of CRC cells. Via this 2-way cross family analysis, we are able to discover through majority voting, the combinations that might of interest to biologists and also derive plausible influences of components of combinations among themselves. Note that these form biological hypotheses which indicate whether a particular combination and the direction of influence within the combination, exist synergistically in CRC cells. Wet lab tests will indicate the veracity of these combinations and if proven true, will lead to further study of mechanism between the components.
Manajemen Lingkungan Berbasis Sekolah Dalam Penanaman Karakter Dan Kesadaran Lingkungan Hidup Berkelanjutan Di Sekolah Dasar
Authors: Nurlinda Safitri  , Arita Marini  , Maratun Nafiah
Published: February 2023

Manajemen lingkungan berbasis sekolah di Sekolah Dasar merupakan suatu sistem yang perlu dilaksanakan dalam upaya untuk membangun karakter serta kesadaran lingkungan hidup yang berkelanjutan di sekolah. Proses manajemen ini terdiri atas perencanaan, pengorganisasian, pelaksanaan serta pengawasan. Tujuan penelitian ini adalah untuk mengintegrasikan proses manajemen lingkungan kedalam stakeholder sekolah di sekolah dasar. Jenis penelitian ini adalah penelitian pustaka dengan metode studi dokumen. Hasil penelitain ini mengenai manajemen lingkungan berbasis sekolah dasar mampu diintegrasikan kepada stakeholder sekolah dalam rangka untuk menciptakan kesadaran lingkungan hidup berkelanjutan.
La visión de la ciencia en Experiment with an Air Pump de Shelagh Stephenson
Authors: Álvarez Castaño Emilio José
Published: February 2023

El cuadro Experiment with an Air Pump (1768) de Joseph Wright of Derby tuvo como gran novedad presentar a la ciencia en el centro de atención artística que hasta entonces había ocupado la religión de manera mayoritaria. Dos siglos más tarde, e inspirándose en esta obra, la dramaturga inglesa Shelagh Stephenson utilizó el recurso de la écfrasis para hacer una reflexión sobre la ciencia desde el teatro. Esta obra teatral presenta dos tramas distintas, una situada a finales del siglo XVIII y otra a finales del siglo XX, que narra de manera alterna en las distintas escenas. En la obra, la ciencia es abordada desde distintos puntos de vista: en relación con la religión, los límites éticos y morales de la ciencia, las mujeres en la ciencia a través de la historia, el extrañamiento y el desconocimiento ante la ciencia. A partir de aquí, se comprobará la vigencia de dichos planteamientos ante los nuevos desafíos a los que la humanidad tiene que hacer frente.
El Camino califal de Córdoba a Toledo: Aspectos geográficos
Authors: Varela Romero Juan
Published: February 2023

Desde el siglo VIII, varios geógrafos e historiadores se han hecho eco de la importancia de los caminos que recorrían al-Andalus. Uno de ellos, de gran importancia por las dos ciudades que unía, ha sido especialmente estudiado, sobre todo en fechas recientes. En este trabajo, se analizan los pormenores geográficos de cada etapa y su complejidad para llevarla a cabo, usando la herramienta digital Google Earth y la elevación del terreno en 3D. Utilizando los textos andalusíes y algunos estudios más modernos, identificaremos el camino optimo, o más utilizado, entre Córdoba y Toledo, localizando los lugares de descanso de cada etapa.
Efficacy and safety of Tong-luo Qu-tong plaster for cervical spondylotic radiculopathy: study protocol for a randomized, double-blind, parallel positive controlled, multicenter clinical trial
Authors: Li Hui , Xie Xingwen , Zhao Yongli , Wang Minzhen , Li Jianguo , Li Dingpeng , Li Ning
Published: February 2023

Background: Cervical spondylotic radiculopathy (CSR) is one of the most common diseases in clinic. Clinical symptoms such as neck pain and upper limb numbness are mainly caused by cervical degenerative changes and compression of cervical nerve roots. The incidence of CSR is the highest among all types of cervical spondylosis, accounting for about 60%~70%, seriously affecting the quality of life and work, causing huge economic negative to patients. Traditional Chinese medicine (TCM) has been definited efficacy and unique advantages in the treatment of CSR. Tongluo Qutong plaster (TLQT) is the most commonly used external drug in China in the treatment of CSR. It is effective for patients to improve neck pain, stiffness and numbness of both upper limbs, but there is a lack of high-quality clinical evidence to support it. The purpose of this study was to evaluate the efficacy and safety of TLQT in the treatment of CSR.
Methods: This is a randomized, double-blind, parallel positive controlled, multi-center clinical trial. 240 patients who met the inclusion criteria were randomly divided into TLQT group and diclofenac sodium plaster group. The treatment period was 3 weeks. Follow-up will be conducted 12 weeks after intervention completion. The main observation index was visual analogue scale (VAS), and the secondary observation index was neck disability index (NDI) and TCM syndrome score. Safety observation indicators will include electrocardiogram, blood tests (including blood routine tests, liver and renal function), routine urine tests, and routine stool tests.The primary and secondary indicators will be performed at 0th, 3th, 7th, 21th and 84th day, and the safety indicators will be performed at 0th, 21th day.
Conclusion: This study will provide evidence for the efficacy and safety of TLQT in treating CSR patients.
Trial registration:This protocol has been registered in Chinese Clinical Trials Registry. Registration number: ChiCTR2200062271. Registered on 31 July 2022.
Plasma D-dimer concentrations as a risk factor in patients with acute heart failure
Authors: Song Li , Feng Yanli , Li Peiwu , Qin Jing , Ma Xiaofeng
Published: February 2023

Objective: The clinical study aims to evaluate the risk factors associated with Acute Heart Failure (AHF) patients, classified according to clinical symptoms and signs.
Methods and findings: 181 AHF patients took part in this cross-sectional clinical investigation. Additionally, there are four categories of AHF patients (warm and wet, warm and dry, cold and wet, and cold and dry) and this not only guides the treatment therapy but also enables the progression of AHF in patients to be assessed.
Results: Based on the results of the standard logistic regression, it can be concluded that individuals with acute heart failure with elevated d-dimer levels were substantially more likely to be "cool and dry" (odds ratio [OR] 1.12, 95% confidence intervals [CI] (0.017;0.212); P=0.022). Additionally, a strong association was identified between the "cold and dry" and the lower patient age (OR 0.95, 95% CI (-0.084;0.011); P=0.011). However, it is important to note that the age differences between the four groups have little clinical significance.
Conclusions: It can be deduced that there is a significant relationship between the essential circumstances of symptoms and signs in patients with AHF and higher d-dimer levels.
Non-clinical Study of Biodistribution of Human Immature Dental Pulp Stem Cells (Nestacell® Product) Following Intravenous Administration in Mice
Authors: Valverde Cristiane Wenceslau , Gamarra Lionel Fernel , Gonzaga Vivian Fonseca , Gárate Ana Paula , Policiquio Bruna de Oliveira , Cintra Luciana , Falcone Cleide , Ynoue Leandro Hideki , Ferrara Luciana , Araldi Rodrigo Pinheiro , Pagani Eduardo , Kerkis Irina
Published: February 2023

Background: Although the safety of mesenchymal stroma/stem cells (MSCs)-based therapies had already extensively demonstrated, non-clinical biodistribution studies are essential for predicting the safety and efficacy of these cells. Herein we assessed the biodistribution of human immature dental pulp stem cells (hIDPSCs), which has investigated as a candidate for the treatment of Huntington’s disease (HD).
Method: For this, we intravenously transplanted hIDPSCs transfected with luciferase or labeled with magnetic nanoparticle in C57BL/6 mice and performed the bioluminescence image (BLI) or inductively coupled plasma mass spectrometer (ICP-MS) to quantity in vivo and ex vivo biodistribution after 4h, 24h, 3, 7, and 30 days of the hIDPSCs administration.
Results: BLI’s results showed the presence of hIDPSCs in the chest, lungs, and head after 4h, 24 h, and 3 days of the cell transplantation. No bioluminescent signal was observed in the chest or head on days 7 and 30 days. The ICP-MS’s results showed that the hIDPSCs engraft into the liver, kidney, heart, and lungs. However, the number of hIDPSCs in these sites significantly reduced from the seventh day, being undetectable on the 30th day. By contrast, we observed that the hIDPSCs not only engrafted into the brain, but also remain in this organ for 30 days.
Conclusion: These data provide evidence that the hIDPSCs successfully engraft and remain in the brain for until 30 days after the cell transplantation, demonstrating that these cells can migrate and homing to the brain, being a useful candidate for the treatment of neurodegenerative disorders, such as HD.
TRIM27 promotes non-small cell lung cancer progression by enhancing P53 degradation
Authors: Hou Guoxin
Published: February 2023

Background: The biological impact and mechanisms of action of tripartite motif 27 (TRIM27) in non-small cell lung cancer (NSCLC) are unclear.
Methods and results: Pan-cancer bioinformatic analysis revealed that TRIM27 expression was elevated in the lung adenocarcinoma and lung squamous cell carcinoma subtypes of NSCLC, and was correlated with unfavorable prognosis in NSCLC patients. Upregulation of TRIM27 mRNA expression in patients may be due to its promoter demethylation and genetic copy number amplification. Further, loss-of-function analysis demonstrated that TRIM27 depletion mitigated NSCLC cell viability, cell cycle progression, migration, invasion, and stemness. Mechanistically, TRIM27 interacted with P53, resulting in the augmentation of P53 ubiquitination levels and degradation. Notably, P53 knockdown significantly alleviated the inhibitory effect of TRIM27 depletion on NSCLC cell malignancy, indicating that P53 is a vital target of TRIM27.
Conclusion: TRIM27 enhances NSCLC progression by targeting P53 for ubiquitination and degradation.
miR-188-5p silencing improves cerebral ischemia/reperfusion injury by targeting Lin28a
Authors: Pei Chaoying , Hou Dan , Yu Dan , Yang Guoshuai
Published: February 2023

This report aimed to explore whether miR-188-5p regulated the pathological regulatory network of cerebral ischemia/reperfusion (I/R) injury. We simulated the cerebral I/R injury model with MACO/R and OGD/R treatments. Neuronal viability and apoptosis were assessed. The contents of miR-188-5p and Lin 28a were evaluated. The abundances of apoptosis-related proteins (Bax, Bcl-2 and cleaved caspase-3) and pro-inflammatory cytokines (TNF-α, 1L-1β, and IL-6) were measured. The interaction of miR-188-5p and Lin28a was confirmed. Lin28a silencing was supplemented to determine the delicate regulation of miR-188-5p. We revealed that miR-188-5p was upregulated and Lin28a was downregulated in I/R rats and OGD/R-induced cells. miR-188-5p silencing remarkably reduced the cerebral infarction volume, neurobehavioral score, brain edema, and Evans blue leakage. miR-188-5p silencing enhanced neuronal viability and alleviated apoptosis. The abundance of Bax and cleaved caspase-3 was reduced by miR-188-5p silencing, while Bcl-2 was augmented. miR-188-5p silencing impeded the contents of TNF-α, 1L-1β, and IL-6. miR-188-5p interacted with Lin28a and negatively regulated its expression. Interestingly, extra Lin28a silencing reversed apoptosis and the content of inflammatory cytokines. Our studies confirmed that miR-188-5p silencing alleviated neuronal apoptosis and inflammation by mediating the expression of Lin28a. The crosstalk of miR-188-5p and Lin28a offered a different direction for ischemic stroke therapy.