bluuebunny/crossref_metadata_2025 huggingface dataset:
Vaccination and the risk of systemic lupus erythematosus: a meta-analysis of observational studies
Authors: Wang Meijiao , Gu Huanpeng , Zhai Yingqi , Li Xuanlin , Huang Lin , Li Haichang , Xie Zhijun , Wen Chengping
Published: March 2024

Objective

This meta-analysis aims to explore the potential link between vaccines and systemic lupus erythematosus (SLE).

Methods

We systematically searched PubMed, Cochrane Library, and Embase for observational studies from inception to September 3, 2023, using medical subject headings (MeSH) and keywords. Study quality was assessed using the NOS scale. Statistical analyses were conducted using STATA software (version 14.0). Publication bias was evaluated using funnel plots and Egger’s regression.

Results

The meta-analysis incorporated 17 studies, encompassing 45,067,349 individuals with follow-up periods ranging from 0.5 to 2 years. The pooled analysis revealed no significant association between vaccinations and an increased risk of SLE [OR = 1.14, 95% CI (0.86–1.52), I2 = 78.1%, P = 0.348]. Subgroup analyses indicated that HBV vaccination was significantly associated with an elevated risk of SLE [OR =2.11, 95% CI (1.11-4.00), I2 = 63.3%, P = 0.02], HPV vaccination was slightly associated with an increased risk of SLE [OR = 1.43, 95% CI (0.88–2.31), I2 = 72.4%, P = 0.148], influenza vaccination showed no association with an increased risk of SLE [OR = 0.96, 95% CI (0.82–1.12), I2 = 0.0%, P = 0.559], and COVID-19 vaccine was marginally associated with a decreased risk of SLE [OR = 0.44, 95% CI (0.18–1.21), I2 = 91.3%, P = 0.118].

Conclusions

This study suggests that vaccinations are not linked to an increased risk of SLE. Our meta-analysis results provide valuable insights, alleviating concerns about SLE risk post-vaccination and supporting further vaccine development efforts.
Prognostic significance of the stress hyperglycemia ratio and admission blood glucose in diabetic and nondiabetic patients with spontaneous intracerebral hemorrhage
Authors: Liang Shengru , Tian Xiaoxi , Gao Fei , Man Minghao , Wang Qi , Li Jianwei , Li Lihong , Yang Yang
Published: March 2024

Background

The role of stress hyperglycemia ratio (SHR) on the prognosis of spontaneous intracerebral hemorrhage (ICH) in patients with different diabetic status has not been elucidated. This study aimed to evaluate the prognostic value of SHR and admission blood glucose (ABG) for the short- and long-term mortality in diabetic and nondiabetic populations with ICH.

Method

Participants with ICH were retrospectively retrieved from the Medical Information Mart for Intensive Care (MIMIC-IV). The primary outcome was all-cause 30-day and 1-year mortality. The association of SHR and ABG with the primary outcomes in diabetic and nondiabetic cohorts were assessed by Cox proportional hazard regression.

Results

Overall, 1029 patients with a median age of 71.09 (IQR: 60.05–81.97) were included. Among them, 548 (53%) individuals were male, and 95 (19%) as well as 323 (31%) ones experienced the 30-day and 1-year mortality, respectively. After adjusting for confounding variables, individuals in quintile 5 of SHR had significantly higher risk of the 30-day and 1-year mortality than those in quintile 1 in the whole cohort (30-day mortality: HR 3.33, 95%CI 2.01–5.51; 1-year mortality: HR 2.09, 95% CI 1.46-3.00) and in nondiabetic patients (30-day mortality: HR 4.55, 95%CI 2.33–8.88; 1-year mortality: HR 3.06, 95%CI 1.93–4.86), but no significant difference was observed in diabetic patients. Similar results were observed for ABG as a categorical variable. As continuous variable, SHR was independently correlated with the 30-day and 1-year mortality in both of the diabetic and nondiabetic cohorts (30-day mortality: HR 2.63, 95%CI 1.50–4.60. 1-year mortality: HR 2.12, 95%CI 1.33–3.39), but this correlation was only observed in nondiabetic cohort for ABG (HR 1.00, 95%CI 0.99–1.01 for both of the 30-day and 1-year mortality). Moreover, compared with ABG, SHR can better improve the C-statistics of the original models regarding the 30-day and 1-year outcomes, especially in patients with diabetes (p < 0.001 in all models).

Conclusion

SHR might be a more useful and reliable marker than ABG for prognostic prediction and risk stratification in critically ill patients with ICH, especially in those with diabetes.
The marine conservation deposits of Monte San Giorgio (Switzerland, Italy): the prototype of Triassic black shale Lagerstätten
Authors: Klug Christian , Spiekman Stephan N. F. , Bastiaans Dylan , Scheffold Beat , Scheyer Torsten M.
Published: March 2024

Marine conservation deposits (‘Konservat-Lagerstätten’) are characterized by their mode of fossil preservation, faunal composition and sedimentary facies. Here, we review these characteristics with respect to the famous conservation deposit of the Besano Formation (formerly Grenzbitumenzone; including the Anisian–Ladinian boundary), and the successively younger fossil-bearing units Cava inferiore, Cava superiore, Cassina beds and the Kalkschieferzone of Monte San Giorgio (Switzerland and Italy). We compare these units to a selection of important black shale-type Lagerstätten of the global Phanerozoic plus the Ediacaran in order to detect commonalities in their facies, genesis, and fossil content using principal component and hierarchical cluster analyses. Further, we put the Monte San Giorgio type Fossillagerstätten into the context of other comparable Triassic deposits worldwide based on their fossil content. The results of the principal component and cluster analyses allow a subdivision of the 45 analysed Lagerstätten into four groups, for which we suggest the use of the corresponding pioneering localities: Burgess type for the early Palaeozoic black shales, Monte San Giorgio type for the Triassic black shales, Holzmaden type for the pyrite-rich black shales and Solnhofen type for platy limestones.
The learning performance of the weak rescaled pure greedy algorithms
Authors: Guo Qin , Liu Xianghua , Ye Peixin
Published: March 2024

We investigate the regression problem in supervised learning by means of the weak rescaled pure greedy algorithm (WRPGA). We construct learning estimator by applying the WRPGA and deduce the tight upper bounds of the K-functional error estimate for the corresponding greedy learning algorithms in Hilbert spaces. Satisfactory learning rates are obtained under two prior assumptions on the regression function. The application of the WRPGA in supervised learning considerably reduces the computational cost while maintaining its powerful generalization capability when compared with other greedy learning algorithms.
Changes in albedo and its radiative forcing of grasslands in East Asia drylands
Authors: Zhu Qingsong , Chen Jiquan , Wu Liangxu , Huang Yuting , Shao Changliang , Dong Gang , Xu Zhe , Li Xianglan
Published: March 2024

Background

Grasslands in drylands are increasingly influenced by human activities and climate change, leading to alterations in albedo and radiative energy balance among others. Surface biophysical properties and their interactions change greatly following disturbances. However, our understanding of these processes and their climatic impacts remains limited. In this study, we used multi-year observations from satellites and eddy-covariance towers to investigate the response of albedo to variables closely associated with human disturbances, including vegetation greenness (EVI) and surface soil volumetric water content (VWC), as well as snow cover and clearness index (Ta) for their potential relationships.

Results

EVI and VWC during the growing season were the primary factors influencing albedo. EVI and VWC were negatively correlated with albedo, with VWC’s total direct and indirect impacts being slightly smaller than those of EVI. During the non-growing season, snow cover was the most influential factor on albedo. VWC and Ta negatively affected albedo throughout the year. We estimated the impact of variations in EVI and VWC on climate to be in the range of 0.004 to 0.113 kg CO2 m−2 yr−1 in CO2 equivalent.

Conclusions

This study indicates the significant impacts of climate change and human disturbances on vulnerable grassland ecosystems from the perspective of altered albedo. Changes in vegetation greenness and soil properties induced by climate change and human activities may have a substantial impact on albedo, which in turn feedback on climate change, indicating that future climate policies should take this factor into consideration.
Decreased eggshell strength caused by impairment of uterine calcium transport coincide with higher bone minerals and quality in aged laying hens
Authors: Fu Yu , Zhou Jianmin , Schroyen Martine , Zhang Haijun , Wu Shugeng , Qi Guanghai , Wang Jing
Published: March 2024

Background

Deteriorations in eggshell and bone quality are major challenges in aged laying hens. This study compared the differences of eggshell quality, bone parameters and their correlations as well as uterine physiological characteristics and the bone remodeling processes of hens laying eggs of different eggshell breaking strength to explore the mechanism of eggshell and bone quality reduction and their interaction. A total of 240 74-week-old Hy-line Brown laying hens were selected and allocated to a high (HBS, 44.83 ± 1.31 N) or low (LBS, 24.43 ± 0.57 N) eggshell breaking strength group.

Results

A decreased thickness, weight and weight ratio of eggshells were observed in the LBS, accompanied with ultrastructural deterioration and total Ca reduction. Bone quality was negatively correlated with eggshell quality, marked with enhanced structures and increased components in the LBS. In the LBS, the mammillary knobs and effective layer grew slowly. At the initiation stage of eggshell calcification, a total of 130 differentially expressed genes (DEGs, 122 upregulated and 8 downregulated) were identified in the uterus of hens in the LBS relative to those in the HBS. These DEGs were relevant to apoptosis due to the cellular Ca overload. Higher values of p62 protein level, caspase-8 activity, Bax protein expression and lower values of Bcl protein expression and Bcl/Bax ratio were seen in the LBS. TUNEL assay and hematoxylin-eosin staining showed a significant increase in TUNEL-positive cells and tissue damages in the uterus of the LBS. Although few DEGs were identified at the growth stage, similar uterine tissue damages were also observed in the LBS. The expressions of runt-related transcription factor 2 and osteocalcin were upregulated in humeri of the LBS. Enlarged diameter and more structural damages of endocortical bones and decreased ash were observed in femurs of the HBS.

Conclusion

The lower eggshell breaking strength may be attributed to a declined Ca transport due to uterine tissue damages, which could affect eggshell calcification and lead to a weak ultrastructure. Impaired uterine Ca transport may result in reduced femoral bone resorption and increased humeral bone formation to maintain a higher mineral and bone quality in the LBS.

Graphical Abstract
Post-pandemic crime trends in England and Wales
Authors: Seyidoglu Hulya , Farrell Graham , Dixon Anthony , Pina-Sánchez Jose , Malleson Nick
Published: March 2024

This study of recorded crime trends in England & Wales spans three and a half years, that is, two covid pandemic years from March 2020  and 18 ‘post-pandemic’ months following cessation of covid restrictions. Observed crime rates were compared to expected (based on 5-year ARIMA models) and the ambient population (using Community Mobility Reports). It finds that, In Year 1, observed rates diverged dramatically from expected, waxing and waning generally in line with the movement restrictions of three national lockdowns. In Year 2, movement restrictions loosened and observed crime rates moved towards but mostly remained far from expected. In post-pandemic Year 3, people’s movement increased and observed crime rates continued towards expected. By mid-Year 4 many rates remained below expected levels, their mean monthly differences including: theft from person (− 22%); burglary (− 20%); vehicle crime (− 29%); violence & sexual offences (− 27%); robbery (− 16%) and; public order offences (− 21%). An exceptional increase in shoplifting achieved 20% above expected rates by August 2023. Methodological limitations and further research on shoplifting and other issues are discussed. The main conclusion is that crime trends generally followed ambient population movement and that enduring lifestyle changes in the post-pandemic period, notably increased work-from-home, account for continuing below-expected rates of many crime types.
Teacher support in language learning: a picture of the effects on language progress, academic immunity, and academic enjoyment
Authors: Huang Lan , Al-Rashidi Anwar Hammad , Bayat Sania
Published: March 2024

Teacher support encompasses the provision of educational, instrumental, sentimental, or evaluative assistance by a teacher to a student, regardless of the setting. Learning a new language brings with it different ups and downs that may hinder the actual progress of the learners. The journey of learning may be made easier by supportive instructors. During the course of this inquiry, two groups (85 participants in total) including the experimental and control groups were chosen to gauge the influence of Teacher support in virtual instruction on English as a foreign language (EFL) learners’ progress, academic immunity, and academic enjoyment. In contrast to the experimental group (EG, n = 42), which had the chance to connect with a teacher in order to ask questions and get feedback plus the off-line education, the control group (CG, n = 44) was subjected to off-line instruction of language input (Top Notch 3). The status of the participants’ language growth, immunity, and enjoyment was investigated both before and after the treatment. The findings of independent samples t-tests as well as the multivariate analysis of variance (MANOVA) indicated that learners in EG did much better than their counterparts in CG. In addition, the ramifications and recommendations for potential future directions are analyzed.
The effect of social media upward comparison on Chinese adolescent learning engagement: a moderated multiple mediation model
Authors: Qi Xinjie , Jiang Yi , Lian Rong
Published: March 2024

To investigate the mechanisms and boundary conditions of social media upward comparison on adolescents’ learning engagement, this study utilized two separate approaches. In research 1, a convenience sampling method was employed to conduct a questionnaire survey among 609 adolescents. The aim was to explore the influence of social media’s upward comparative tendency on learning engagement. In research 2, real social media platforms were utilized to select short videos as experimental materials. These materials were used to manipulate instantaneous social media upward comparison and examine its impact on learning engagement. The research 1’s result indicated that the mediating effect of the sense of agency was significant, as well as the moderating effect of growth mindset. However, the mediating effect of positive-negative emotions was found to be insignificant.Regarding instantaneous social media upward comparison and learning engagement, positive and negative emotions were found to play a complete mediating role. However, the mediating role of agency and the moderating role of growth mindset were not significant.This study offers practical insights for educators, enabling them to develop a correct understanding and effectively regulate adolescents’ use of social media.
Clinical effectiveness, cost-effectiveness and process evaluation of group schema therapy for eating disorders: study protocol for a multicenter randomized controlled trial
Authors: Mares Suzanne H. W. , Roelofs Jeffrey , Zinzen Janôt , Béatse Manouk , Elgersma Hermien J. , Drost Ruben M. W. A. , Evers Silvia M. A. A. , Elburg Annemarie A. van
Published: March 2024

Background

Eating disorders (EDs), such as (atypical) Anorexia (AN) and Bulimia Nervosa (BN), are difficult to treat, causing socioeconomic impediments. Although enhanced cognitive behavioral therapy (CBT-E) is widely considered clinically effective, it may not be the most beneficial treatment for (atypical) AN and BN patients who do not show a rapid response after the first 4 weeks (8 sessions) of a CBT-E treatment. Alternatively, group schema therapy (GST) may be a valuable treatment for this ED population. Even though GST for EDs has yielded promising preliminary findings, the current body of evidence requires expansion. On top of that, data on cost-effectiveness is lacking. In light of these gaps, we aim to describe a protocol to examine whether GST is more (1) clinically effective and (2) cost-effective than CBT-E for (atypical) AN and BN patients, who do not show a rapid response after the first 4 weeks of treatment. Additionally, we will conduct (3) process evaluations for both treatments.

Methods

Using a multicenter RCT design, 232 Dutch (atypical) AN and BN patients with a CBT-E referral will be recruited from five treatment centers. Clinical effectiveness and cost-effectiveness will be measured before treatment, directly after treatment, at 6 and at 12 months follow-up. In order to rate process evaluation, patient experiences and the degree to which treatments are implemented according to protocol will be measured. In order to assess the quality of life and the achievement of personalized goals, interviews will be conducted at the end of treatment. Data will be analyzed, using a regression-based approach to mixed modelling, multivariate sensitivity analyses and coding trees for qualitative data. We hypothesize GST to be superior to CBT-E in terms of clinical effectiveness and cost-effectiveness for patients who do not show a rapid response to the first 4 weeks of a CBT-E treatment.

Discussion

To our knowledge, this is the first study protocol describing a multicenter RCT to explore the three aforementioned objectives. Related risks in performing the study protocol have been outlined. The expected findings may serve as a guide for healthcare stakeholders to optimize ED care trajectories.

Trial registration

clinicaltrials.gov (NCT05812950).
Experiential avoidance in participants with borderline personality disorder and other personality disorders
Authors: Gecha Tess C. , Glass Isabel V. , Frankenburg Frances R. , Sharp Carla , Zanarini Mary C.
Published: March 2024

Background

The present study has descriptive and predictive aims. The descriptive aims were to determine if participants with borderline personality disorder (BPD) reported higher levels of experiential avoidance (EA) than participants with other personality disorders (OPD) as well as determine if non-recovered participants with BPD reported higher levels of EA than participants with BPD who have recovered symptomatically and psychosocially. The predictive aim was to determine if the level of EA reported by participants with BPD was predicted by the severity of aspects of childhood or adult adversity and/or aspects of temperament.

Methods

The Overall Anxiety Severity and Impairment Scale (OASIS) was administered to 248 participants at 24-year follow-up in the McLean Study of Adult Development (MSAD). Adversity and temperament were assessed during index admission using interviews (Revised Childhood Experience Questionnaire [CEQ-R], Adult History Interview [AHI], and the NEO-FFI self-report measure).

Results

Participants with BPD reported significantly higher levels of EA than those with OPD. Within the BPD group, non-recovered participants reported significantly higher levels of EA than recovered participants. Severity of childhood sexual abuse and lower levels of extraversion were found to be significant multivariate predictors of levels of EA in those with BPD.

Conclusions

Taken together, these results suggest that EA is a serious problem for participants with BPD, particularly those who have not recovered. They also suggest that both the severity of childhood adversity and a temperament marked by lower levels of extroversion are significantly related to levels of EA reported by participants with BPD.
Investigating antiviral activities of iodine-conjugated organic agents against major viruses infecting pepper in Korea
Authors: Choi Hoseong , Jang Suyeon , Jung Minhue , Kwon Sun-Jung , Kim Hee Kyong , Kang Hyoung-Gon , Lee Daehong , Kim Kook-Hyung
Published: March 2024

Background

Plant viruses cause economic losses by reducing the quantity and quality of major crops. This issue is a growing concern due to the expansion of global trade and climate change. In addition, the emergence of new pathogen strains increases the difficulty of controlling viral diseases. Effective management strategies are therefore needed. The control strategy for viral diseases relies primarily on non-chemical and cultural practices, as no commercial viricides are currently available. Some compounds have been identified as effective against certain viruses, but their use in the field is limited due to issues such as concentration, toxicity, and efficacy. Therefore, it is imperative to discover novel antiviral agents that address the existing challenges associated with the identified antiviral candidate compounds.

Results

In this study, we evaluated iodine-conjugated organic compounds mixed with sialic acid, whey, and blood meal for virus disease management against seven viruses that cause significant yield losses and economic damage to plants. The candidate compounds reduced virus accumulation and symptom development. Treatment with candidate compounds, A4 and A5, reduced viral RNA accumulation to about half that of those in the control group and showed reduced symptoms along with healthier growth. In addition, we performed transcriptome analysis of treatment with two viruses, which suggested that the mechanism of viral RNA replication inhibition might relate to plant defense systems based on phytohormone pathways.

Conclusions

This study demonstrated that treatments with naturally derived materials, such as iodine, nitrogen, and sialic acid-conjugated organic substances, may directly or indirectly impact the host plant's resistance to various virus infections. Moreover, our findings suggest that these natural candidate materials could be utilized for managing virus diseases in the field.

Graphical Abstract
Examining the role of firearm involvement in repeat intimate partner violence assaults
Authors: Hans Zainab , Cooper Chiara E. , Zeoli April M.
Published: March 2024

Background

Intimate partner violence (IPV) remains a pervasive and complex issue with significant social and public health implications. The nexus of firearms and intimate partner violence (IPV) is an especially dangerous one. However, little is known about how firearm involvement can influence the risk of repeat IPV assaults.

Methods

We use data from 346 male perpetrated IPV incidents reported to the Detroit Police Department between December 2016 and April 2017 to examine the role of firearm involvement in IPV recidivism during a 5 and half year follow up period. Employing a conditional gap-time frailty model that accommodates heterogeneity among individuals through a frailty term, we analyze time to multiple IPV assaults that occur over the follow up period. We identify various pathways through which firearms impact the likelihood of subsequent IPV incidents, including intimidation, threats, and use of firearms, while controlling for observable perpetrator characteristics to understand the explicit roles of firearms.

Results

Firearm involvement at the index assault was not associated with IPV recidivism. However, involvement of firearms in past IPV assaults significantly increased the risk of subsequent physical IPV. The discrepancy is likely arising from a high degree of censoring among individuals who were armed with a firearm during the index assault.

Conclusion

Our research reveals a nuanced relationship between firearm involvement and IPV recidivism, shedding light on the multifaceted dynamics at play. By elucidating the intricate dynamics at the intersection of firearms and intimate partner violence, our study underscores the need for targeted policy interventions and preventative measures aimed at reducing IPV recidivism.
Amide proton transfer-weighted imaging and stretch-exponential model DWI based 18F-FDG PET/MRI for differentiation of benign and malignant solitary pulmonary lesions
Authors: Meng Nan , Song Chen , Sun Jing , Liu Xue , Shen Lei , Zhou Yihang , Dai Bo , Yu Xuan , Wu Yaping , Yuan Jianmin , Yang Yang , Wang Zhe , Wang Meiyun
Published: March 2024

Objectives

To differentiate benign and malignant solitary pulmonary lesions (SPLs) by amide proton transfer-weighted imaging (APTWI), mono-exponential model DWI (MEM-DWI), stretched exponential model DWI (SEM-DWI), and 18F-FDG PET-derived parameters.

Methods

A total of 120 SPLs patients underwent chest 18F-FDG PET/MRI were enrolled, including 84 in the training set (28 benign and 56 malignant) and 36 in the test set (13 benign and 23 malignant). MTRasym(3.5 ppm), ADC, DDC, α, SUVmax, MTV, and TLG were compared. The area under receiver-operator characteristic curve (AUC) was used to assess diagnostic efficacy. The Logistic regression analysis was used to identify independent predictors and establish prediction model.

Results

SUVmax, MTV, TLG, α, and MTRasym(3.5 ppm) values were significantly lower and ADC, DDC values were significantly higher in benign SPLs than malignant SPLs (all P < 0.01). SUVmax, ADC, and MTRasym(3.5 ppm) were independent predictors. Within the training set, the prediction model based on these independent predictors demonstrated optimal diagnostic efficacy (AUC, 0.976; sensitivity, 94.64%; specificity, 92.86%), surpassing any single parameter with statistical significance. Similarly, within the test set, the prediction model exhibited optimal diagnostic efficacy. The calibration curves and DCA revealed that the prediction model not only had good consistency but was also able to provide a significant benefit to the related patients, both in the training and test sets.

Conclusion

The SUVmax, ADC, and MTRasym(3.5 ppm) were independent predictors for differentiation of benign and malignant SPLs, and the prediction model based on them had an optimal diagnostic efficacy.
Evaluation of a new dynamic real-time visualization 25 kHz swept-source optical coherence tomography based biometer
Authors: Yu Jinjin , Lin Xuanqiao , Huang Xiaomin , Xu Zhenyu , Ning Rui , Li Kexin , Savini Giacomo , Schiano-Lomoriello Domenico , Zhou Xingtao , Huang Jinhai
Published: March 2024

Background

To evaluate the intraobserver repeatability and interobserver reproducibility of a newly developed dynamic real-time visualization 25 kHz swept-source optical coherence tomography (SS-OCT) based biometer (ZW-30, TowardPi Medical Technology Ltd, China) and compare its agreement with another SS-OCT based biometer (IOLMaster 700, Carl Zeiss Meditec AG, Jena, Germany).

Methods

Eighty-two healthy right eyes were enrolled in this prospective observational study. Measurements were repeated for three times using the ZW-30 and IOLMaster 700 in a random order. Obtained parameters included axial length (AL), central corneal thickness (CCT), aqueous depth (AQD), anterior chamber depth (ACD), lens thickness (LT), mean keratometry (Km), astigmatism magnitude (AST), vector J0, vector J45, and corneal diameter (CD). The within-subject standard deviation (Sw), test–retest (TRT) variability, coefficient of variation (CoV), and intraclass correlation coefficient (ICC) were adopted to assess the intraobserver repeatability and interobserver reproducibility. The double-angle plot was also used to display the distribution of AST. To estimate agreement, Bland–Altman plots were used.

Results

For the intraobserver repeatability and interobserver reproducibility, the Sw, TRT and CoV for all parameters were low. Meanwhile, the ICC values were all close to 1.000, except for the J45 (ICC = 0.887 for the intraobserver repeatability). The double-angle plot showed that the distribution of AST measured by these two devices was similar. For agreement, the Bland–Altman plots showed narrow 95% limits of agreements (LoAs) for AL, CCT, AQD, ACD, LT, Km AST, J0, J45, and CD (− 0.02 mm to 0.02 mm, − 7.49 μm to 8.08 μm, − 0.07 mm to 0.04 mm, − 0.07 mm to 0.04 mm, − 0.07 mm to 0.08 mm, − 0.16 D to 0.30 D, − 0.30 D to 0.29 D, − 0.16 D to 0.16 D, − 0.23 D to 0.13 D, and − 0.39 mm to 0.10 mm, respectively).

Conclusions

The newly dynamic real-time visualization biometer exhibited excellent intraobserver repeatability and interobserver reproducibility. The two devices both based on the SS-OCT principle had similar ocular parameters measurement values and can be interchanged in clinical practice.
Evaluation of a joint workshop on study design for hospital and community pharmacists: a retrospective cross-sectional survey
Authors: Asai Yuki , Takai Yasushi , Murasaka Toshiki , Miyake Tomohiro , Nakamura Tomohisa , Morikawa Yoshihiko , Nakagawa Yuji , Kanayama Tatsuya , Abe Yasuharu , Masuda Naoki , Takamura Yasushi , Miki Yoshihiro , Iwamoto Takuya
Published: March 2024

Background

Although pharmacists often identify numerous clinical questions, they face several barriers, including the lack of mentors for research activities in clinical settings. Therefore, a workshop for the appropriate selection of a study design, which is a fundamental first step, may be necessary. The purpose of this study was to evaluate the effectiveness of a workshop on study design for hospital and community pharmacists. Moreover, the characteristics of pharmacists with little involvement in research activities were extracted using decision-tree analysis to guide the design of future workshops.

Methods

A workshop was conducted on October 1, 2023. It comprised three parts: lectures, group work, and presentations. Questionnaire-based surveys were conducted with workshop participants regarding their basic information, their background that influenced research activities, their satisfaction, and their knowledge/awareness. For the questions on knowledge/awareness, the same responses were requested before and after the workshop using a five-scale scoring system. Multivariate logistic regression analysis was conducted to identify independent factors influencing research activities. Decision tree analysis was performed to extract low-effort characteristics of the research activities.

Results

Of the 40 workshop attendees, the overall satisfaction score for the workshop was 4.38 of 5, and the score for each question was 4 or higher. Significant increases were observed in the scores of knowledge/awareness after the workshop. Moreover, 95% of the pharmacists answered that it would be highly useful to conduct a joint workshop between hospitals and community pharmacists. Although independent influencing factors were not detected in the multivariate logistic regression analysis, the decision tree analysis revealed that pharmacists who were no member of an academic society (85%, 11/13) or members without any certifications or accreditations related to pharmacy practice (80%, 4/5) were the least active in clinical research. In contrast, those belonging to academic societies and holding certifications or accreditations related to pharmacy practice frequently conducted clinical research.

Conclusion

The present study revealed that a joint workshop on study design may have the potential to change pharmacists’ knowledge and awareness of research activities. Moreover, future workshops should be conducted with pharmacists who do not belong to academic societies.
Dietary mineral intakes predict Coronavirus-disease 2019 (COVID-19) incidence and hospitalization in older adults
Authors: Seifi Najmeh , Bahari Hossein , Ghiasi Hafezi Somayeh , Ghotbani Farzaneh , Afzalinia AhmadReza , Ferns Gordon A. , Farkhani Ehsan Mosa , Ghayour-mobarhan Majid
Published: March 2024

Background

The aim of this study was to determine the association between dietary mineral intake and Coronavirus-disease 2019 (COVID-19) infection and its associated hospitalization.

Methods

This cohort study utilized the MASHAD study population, which comprised individuals aged 35–65. Upon recruitment in 2007, dietary intake was documented using a validated 65-item food frequency questionnaire (FFQ). Data on COVID-19 PCR test results was collected from all relevant medical centers in Mashhad between February 2020 and June 2022. The regression model included dietary minerals and employed the backward variable selection method, along with advanced data analysis techniques.

Results

The final analysis involved 1957 participants, including 193 COVID-19-positive patients. The mean age was 49.71 and 50.28 years in the COVID-19-positive and negative groups, respectively (p = 0.12). Dietary intakes of magnesium, iron, and potassium were notably lower in COVID-19-positive patients (P < 0.05). Following adjustments for age and sex, dietary iron remained significantly associated with COVID-19 incidence (OR = 0.94, 95% CI: 0.90–0.98). Furthermore, a statistically significant relationship was observed between dietary zinc and hospitalization due to COVID-19 (OR = 0.69, 95% CI: 0.51–0.93). In dynamical system models, intakes of calcium, zinc, and iron below the cut-offs of 1138, 9.7, and 8.17 mg/day, respectively, were linked to an increased risk of COVID-19 incidence.

Conclusion

Higher dietary iron and zinc intake are associated with decreased risk of COVID-19 infection and hospitalization, respectively.
Body mass index as a dominant risk factor for metabolic syndrome among indonesian adults: a 6-year prospective cohort study of non-communicable diseases
Authors: Rahmawati Nurul Dina , Andriani Helen , Wirawan Fadila , Farsia Latifah , Waits Alexander , Karim Taufiqurahman Khobir Abdul
Published: March 2024

Background

Non-communicable diseases (NCDs), notably cardiovascular disease and type 2 diabetes mellitus, are largely driven by metabolic syndrome (MetS), a cluster of critical risk factors. Despite extensive research, the progression of MetS, especially in Indonesia, has received limited attention. This research tracks adult MetS risk dynamics in a populous Bogor District cohort, providing crucial insights into its evolving nature.

Methods

This prospective open cohort study analysed secondary data from the Special Research - Cohort Study of Non-Communicable Diseases by the Ministry of Health, Republic of Indonesia from 2011 to 2018. The final sample was 1,376 Indonesian adult participants, all residents of Bogor District. MetS outcome, dietary assessment, physical activity, and biomarkers were analysed every two consecutive years.

Results

The risk of overweight and obese participants developing MetS was 2.4 and 4.4 times higher, respectively (95% CI: 1.176–3.320 and 3.345–5.740) than those with body mass index (BMI) in the normal range. Participants who reported less intentional physical exercise had a MetS risk 1.5 times higher (95% CI: 1.034–2.109) than those with more intentional physical exercise. The role of diet is also significant, evidenced by a 30% reduction in MetS risk for people with fat intakes in the 2nd quartile compared to the 1st quartile (95% CI: 0.505–0.972). Meanwhile, a carbohydrate intake in the 2nd quartile increased the risk of MetS 1.5 times (95% CI: 1.063–2.241) in comparison with the 1st quartile.

Conclusions

Notably, participants with underweight BMI exhibited the highest cumulative survival of MetS, while those with obese BMI recorded the lowest cumulative survival. There is an urgent need for strategic interventions to enhance the existing early detection and NCD monitoring program. This involves a targeted focus on promoting a community-based healthy lifestyle in the Bogor District. The study emphasizes the importance of tailored public health measures to address specific risk factors identified in the local context, aiming to mitigate the prevalence and impact of MetS in the population.
The modulation effect of green tea and pumpkin oils on hyperlipidemia, oxidative stress, and hematological abnormalities in an experimental multiple sclerosis rat model
Authors: Lamloum Nahed S. , Soliman Hanan A. , Ahmed Rasha Rashad , Ahmed Osama M. , Zaky Mohamed Y.
Published: March 2024

Background

Multiple sclerosis (MS) is a chronic inflammatory condition that can impair the body’s physiological functions. Although many diseases have been successfully treated with herbal treatments for a long time, the majority of the herbs utilized have unclear mechanisms. Therefore, this study aimed to examine the modulation effects of green tea oil (GTO) and pumpkin oil (PO) on hyperlipidemia, oxidative stress, and hematological abnormalities in an experimental multiple sclerosis rat model.

Methods

Forty albino male Wistar rats (weighing 120–140 g) were divided into four groups of six each: group 1, the control group; group 2, the myelin oligodendrocyte glycoprotein (MOG)-injected group; and groups 3 and 4, the MOG-injected groups treated with GTO and PO at 5 mg/kg b.w., respectively. At the end of the experiments, animals were anesthetized with diethyl ether inhalation, and blood samples were collected from the jugular vein. A Beckman Coulter was then used to determine the differential complete blood counts. The obtained serum was rapidly collected and stored at 20 °C to assess the lipid profile and oxidative stress and antioxidant biomarkers.

Results

Our findings showed that GTO and PO treatment produced a significant reduction in total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and very low-density lipoprotein-cholesterol (VLDL-C) levels. Furthermore, GTO and PO treatment alleviated the elevated cardiovascular risk indices 1 and 2. Thiobarbituric acid reactive substance (TBARS) concentration significantly decreased and glutathione (GSH), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels significantly increased in rats injected with MOG and treated with GTO and PO. Furthermore, after GTO and PO treatment, the reduced red blood cells (RBCs) count, hemoglobin content (Hb%), lymphocyte percentage, and hematocrit (HCT) of MOG-injected rats increased, while the elevated white blood cells (WBCs), platelet, and neutrophil percentage substantially declined.

Conclusion

Collectively, our research revealed that GTO and PO may be capable of modulating hyperlipidemia, oxidative stress, and hematological abnormalities in the MS rat model.
Prognostic factors of oral squamous cell carcinoma: the importance of recurrence and pTNM stage
Authors: Kim Min Jae , Ahn Kang-Min
Published: March 2024

Background

Oral squamous cell carcinoma has a poor prognosis. Therefore, prognostic factors are important to increase the survival rate. This study assessed the survival rate and the prognostic factors for survival of patients with oral squamous cell carcinoma.

Method

This study included 168 patients who underwent surgery for oral squamous cell carcinoma between January 2006 and December 2021. The survival rate was analyzed with overall survival and disease-specific survival. The patient’s age, sex, pTNM stage, primary sites (lip, tongue, mouth of floor, mandibular gingiva, maxillary gingiva, mandibular vestibule, maxillary vestibule, retromolar trigone, palate, buccal mucosa, primary intra-osseous site), smoking and alcohol drinking habits, depth of invasion, perineural and lymphovascular invasion, cell differentiation, and postoperative radiotherapy were evaluated to analyze risk factors. Kaplan–Meier methods were used to estimate the survival rates. Cox regression methods were used to investigate the main independent predictors of survival in univariable and multivariable analysis.

Results

Sixty-eight patients died of oral squamous cell carcinoma during follow-up periods. Their overall survival for 5 years was 51.2%, and the disease-specific survival was 59.2%. In univariable analysis, seven factors which are neck metastasis, depth of invasion, cell differentiation, lymphovascular invasion, postoperative radiotherapy, pTNM stage, and recurrence were significantly associated with survival. In multivariable analysis, pTNM stage and recurrence were significantly associated with survival.

Conclusion

In patients with oral squamous cell carcinoma, pTNM stage and recurrence were significant prognostic factors. Neck metastasis, depth of invasion, cell differentiation, lymphovascular invasion, and postoperative radiotherapy were also prognostic factors. These factors serve as markers for obtaining prognosis information in oral squamous cell carcinoma.
A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain
Authors: Sakai Takayuki , Ogata Aya , Ikenuma Hiroshi , Yamada Takashi , Hattori Saori , Abe Junichiro , Imamura Shinichi , Ichise Masanori , Tada Mari , Kakita Akiyoshi , Koyama Hiroko , Suzuki Masaaki , Kato Takashi , Ito Kengo , Kimura Yasuyuki
Published: March 2024

Background

Heat shock proteins (HSPs) are present throughout the brain. They function as molecular chaperones, meaning they help with the folding and unfolding of large protein complexes. These chaperones are vital in the development of neuropathological conditions such as Alzheimer’s disease and Lewy body disease, with HSP90, a specific subtype of HSP, playing a key role. Many studies have shown that drugs that inhibit HSP90 activity have beneficial effects in the neurodegenerative diseases. Therefore, HSP90 PET imaging ligand can be used effectively to study HSP90 in neurodegenerative diseases. Among four HSP90 isoforms, two cytosolic isoforms (HSP90α and HSP90β) thought to be involved in the structural homeostasis of the proteins related to the neurodegenerative diseases. Currently, no useful PET imaging ligands selectively targeting the two cytosolic isoforms of HSP90 have been available yet.

Results

In this study, we developed a novel positron emission tomography (PET) imaging ligand, [11C]BIIB021, by 11C-radiolabeling (a positron emitter with a half-life of 20.4 min) 6-Chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine (BIIB021), an inhibitor with a high affinity for and selectivity to HSP90α and HSP90β. [11C]BIIB021 was synthesized with a high yield, molar activity and radiochemical purity. [11C]BIIB021 showed a high binding affinity for rat brain homogenate as well as human recombinant HSP90α and HSP90β proteins. Radioactivity was well detected in the rat brain (SUV 1.4). It showed clear specific binding in PET imaging of healthy rats and autoradiography of healthy rat and human brain sections. Radiometabolite was detected in the brain, however, total distribution volume was well quantified using dual-input graphical model. Inhibition of p-glycoprotein increased brain radioactivity concentrations. However, total distribution volume values with and without p-glycoprotein inhibition were nearly the same.

Conclusions

We have developed a new PET imaging agent, [11C]BIIB021, specifically targeting HSP90α/β. We have been successful in synthesizing [11C]BIIB021 and in vitro and in vivo imaging HSP90α/β. However, the quantification of HSP90α/β is complicated by the presence of radiometabolites in the brain and the potential to be a substrate for p-glycoprotein. Further efforts are needed to develop radioligand suitable for imaging of HSP90α/β.
Clinical characteristics and risk factors associated with bone erosion in patients with tophi
Authors: Ji Zhuyi , Huang Yukai , Liang Ling , Lin Paifeng , Guo Xin , Huang Qidang , Huang Zhengping , Chen Shuyang , Huang Zhixiang , Wang Biao , Huang Lixin , Sun Shanmiao , Deng Weiming , Li Tianwang
Published: March 2024

Introduction

If a large amount of urate crystals is deposited in a joint cavity for an extended period of time, bone erosion will occur and gradually cause skeletal muscle necrosis and joint deformity. The aim of this study was to describe the clinical characteristics and factors associated with bone erosion in gout patients with tophi.

Methods

A total of 210 gout patients with tophi were enrolled and divided into a bone erosion group (n = 135) and a non-bone erosion group (n = 75). Digital radiography (DR) was performed to detect bone erosion in the elbow, wrist, knee, ankle joints, interphalangeal and metatarsophalangeal joints. The clinical characteristics were recorded and compared between the two groups. Multivariate logistic regression analysis was conducted to explore the factors associated with bone erosion.

Results

Compared with the non-bone erosion group, the bone erosion group had an older age, longer disease duration of gout and tophi, higher level of serum creatinine (sCr), higher proportion of drinking history and ulceration, and a lower glomerular filtration rate (GFR). Univariate logistic regression analysis results showed that sex, age, body mass index (BMI), gout duration, tophi duration, GFR, white blood cell (WBC) count, sCr level, smoking history, drinking history, and presence of ulceration were associated with bone destruction. Multivariable logistic regression analysis results indicated that tophi duration, drinking history, ulceration and sCr were positively and independently related to bone erosion.

Conclusions

Tophi patients with bone erosion presented different clinical characteristics. Tophi duration, drinking history, ulceration and sCr were associated with bone erosion in gout patients with tophi.
Are science competitions meeting their intentions? a case study on affective and cognitive predictors of success in the Physics Olympiad
Authors: Tschisgale Paul Leon , Steegh Anneke , Petersen Stefan , Kubsch Marcus , Wulff Peter , Neumann Knut
Published: March 2024

Contemporary science competitions particularly have two intentions: (1) identifying the students demonstrating the highest levels of domain-specific cognitive abilities and (2) recognizing and valuing the efforts of engaged and motivated students, even those without exceptional abilities. This study aimed to examine the relative influence of affective and cognitive variables on predicting success among 136 participants of the first two rounds of the German Physics Olympiad, and based on that, evaluate the extent to which the Physics Olympiad meets the outlined intentions. Our findings indicate that the competition’s initial round erects a hurdle for engaged and motivated students who lack sufficient cognitive abilities, which goes against the above mentioned second intention. Conversely, the Physics Olympiad appears to effectively align with its first intention by successfully identifying students with high developed physics-specific abilities. Building on our findings, we discuss ways for better aligning the competition with its intentions, thus contributing to the ongoing further development of science competitions.