bluuebunny/crossref_metadata_2025 huggingface dataset:
Electronic journal as a tool for monitoring students' success in the process of receiving Higher Education
Authors: YATSUKH Oleh , ZORIA Mykhailo
Published: June 2023

The article highlights the results of the implementation of an electronic record of the success of students of the Dmytro Motornyi Tavria State University of Agricultural Technology as an effective tool for rationalizing the educational process, which allows more effective use of the working time of scientific and pedagogical workers, increases the objectivity of evaluation, timely identification of educational problems, forecasting and to adjust the further educational activities of the students, to motivate their work in classes.
Features of the activities of regional institutions of post-graduate pedagogical education in the conditions of war: challenges and new solutions
Authors: KLIASEN Nataliia
Published: June 2023

The article examines the state of activity of regional institutions of post-graduate pedagogical education in the conditions of war, focused on the modernization of the content of education, which is aimed at the implementation of the tasks of reforming general secondary education. The presented material is based on the results of the analysis of scientific-methodical and innovative project activities implemented in practice by regional institutions of postgraduate pedagogical education. The author identified the actual tasks of training teaching staff to implement innovative activities, the leading provisions of the «New Ukrainian School» Concept, the implementation of the new State Standard of Basic Secondary Education, aimed at improving the system of ensuring the quality of education and their professional growth.
To the Anniversary of the Department of Philosophy and Methodology of Economics (2013–2023)
Authors: Rogozhnikova V. N. , Tutov L. A.
Published: June 2023

The review of the results of educational and scientific work of the Department of Philosophy and Methodology of Economics of the Faculty of Economics of Lomonosov Moscow State University for the period from 2013 to 2023 is presented. The development strategy, mission, purpose and main tasks of the department are defined. The main achievements of the department are shown and prospects for its further development are outlined.
Reconstruction of Marx's Theory of Foreign Trade: How Rich Countries Got Rich
Authors: Sorokin A. V.
Published: June 2023

Ricardo's theory of comparative advantages is considered to be the only classical theory of foreign trade. In terms of Marx's six books, "Foreign Trade" was supposed to be the fifth book. But the logic of the model – from the abstract to the concrete – allows us to detect elements of the theory of foreign trade in the published volumes of Capital. In volume I, a provision is put forward according to which countries exporting high-tech goods increase national value wealth.

Volume III examines at the national level the law of the average rate of profit, which is carried out by redistributing the value created in labor-intensive industries in favor of capital–intensive industries through prices: prices for labor–intensive goods decrease, and prices for capital–intensive ones increase.

The law of the average rate of profit operates at the international level. The wealth of nonindustrial countries is redistributed in favor of industrial ones. The reconstructed theory of Marx explains «How rich countries got rich... and why poor countries stay poor» (E. Reinert).
Continous Medical Eduation needs and influenced factors among clinical nurses in Tien Giang general hospital in 2021
Authors:   Hanoi Medical University, Bui Thi My Anh , Giang Thi Mong Huyen ,   Go Cong general hospital, Nguyen Van Duong ,   Tien Giang Health Department
Published: June 2023

The study aimed to describe the needs and determine influenced factors continuous medical education needs among nurses in Tien Giang general hospital in 2021. A cross-sectional study was conducted with combining quantitative and qualitative approaches. A total of 246 clinical nurses was selected in this study for a self-administered questionnaire and the hospital director, head nurse, and nurses were invited for in-depth interview and focus group discussions. The results showed that 95.1% of nurses had a need for continuous medical education, in which the highest need was training in soft skills and patient care techniques. The desired training location was at the provincial general hospital, the duration of the training course was less than 7 days. Most clinical nurses chose the form of concentrated training that combines theory and practice approaches. Some factors related to financial issues, the burden of workload and job position were negative influenced factors on the training need of clinical nurses. Other factors including need for promotion, and training management were positive influenced factors on continuous medical training among clinical nurses. Keywords: Continous Medical Educaltion (CME), training need assessment, nurses, hosipital, Tien Giang general hospital
Survey results on social, cultural and community health capacity in maternal and newborn care of midwives at commune level in Vietnam in the period 2021-2022
Authors:   Department of Science, Technology and Training, Ministry of Health, Pham Van Tac , Nguyen Duc Thanh ,   Hanoi University of Public Health, Chu Huyen Xiem ,   Hanoi University of Public Health, Phung Thanh Hung ,   Hanoi Medical University, Bui Thi My Anh ,   Hanoi Medical University, Pham Quynh Anh ,   Hanoi University of Public Health, Pham Thi Huyen Chang ,   Hanoi University of Public Health, Duong Thi Tien ,   Hanoi University of Public Health, Vu Thi Hau ,   Hanoi University of Public Health
Published: June 2023

The purpose of the study was to ascertain the social, cultural, and community health capacity for maternity and newborn care provided by midwives at the commune level in Vietnam over the years 2021–2022. Methods: From May 2021 to August 2022, 300 midwives in the provinces of Bac Ninh, Tuyen Quang, Dak Lak, Khanh Hoa, Dong Thap, and Dong Nai participated in a cross-sectional descriptive study utilizing questionnaires and interviews. Results: Basic social, cultural, and public health competences in maternity and child care include basic social, cultural, and public health abilities for caring for pregnant women and newborns. Midwives deliver babies at a rate of 80.5%. Increasing social, cultural, and public health capabilities in maternity and neonatal care A 54.8% midwifery rate. Conclusion: Basic social, cultural, and community health competences in care: Social, cultural, and community health basic and extended skills in maternity and neonatal care A high percentage of midwives provide maternal and neonatal care. In order to support the team in developing soft skills and professional skills at work, the study presents recommendations for strengthening midwives' professional skill and soft skill training. Keywords: Capacity, midwifery, commune level, maternal and newborn care
STRATEGY OF THE NEW INDUSTRIALIZATION OF THE PHARMACEUTICAL INDUSTRY: NATIONAL PRIORITIES AND NEW CHALLENGES
Authors:   Center for Innovative Economics and Industrial Policy of the Institute of Economics of the Russian Academy of Sciences, DORZHIEVA VALENTINA V.
Published: June 2023

The article analyzes the strategic priorities of technological modernization of the pharmaceutical industry in the conditions of external constraints. The study showed that with the increasing sanctions pressure on Russia, it is necessary to revise strategic priorities and industrial policy instruments, including the strategy of new industrialization being implemented. The conclusion is made that, despite the decrease in the level of dependence on imports, the industrial policy on import substitution is characterized by fragmentation and it has a catch-up character.
Integrative species delimitation in the morphologically conservative Stegana subgen. Orthostegana (Diptera, Drosophilidae)
Authors: Wang Ya-Lian , Peng Zi-Qi , Jin Feng-Liang , Chen Hong-Wei , Huang Jia
Published: June 2023

With the increasing number of cryptic species discovered in major branches of the subfamily Steganinae, accurate species identification is becoming challenging. Possible evolutionary stasis often gives rise to the formation of morphological conservatism and cryptic species, as is the case for the members of the Stegana (subgen. Orthostegana). In this study, the species boundaries of all Asian Orthostegana were accessed based on two mitochondrial genes [cytochrome c oxidase subunit I (COI) and NADH dehydrogenase subunit 2 (ND2)] using different species delimitation methods and evolutionary models. By integrating morphological and molecular evidence, we clearly validated the evolutionary independence of all five known species and identified nine new species from Southwest China: Stegana (Orthostegana) aini Peng & Chen sp. nov., S. (O.) brevivittata Peng & Chen sp. nov., S. (O.) cuodi Peng & Chen sp. nov., S. (O.) fuscofemorata Peng & Chen sp. nov., S. (O.) latipalpula Peng & Chen sp. nov., S. (O.) macrostephana Peng & Chen sp. nov., S. (O.) mohnihei Peng & Chen sp. nov., S. (O.) obscurala Peng & Chen sp. nov., and S. (O.) pinguitia Peng & Chen sp. nov. Moreover, we discussed the relationship between the Asian Orthostegana lineage and the subgen. Oxyphortica, and the necessity of taxonomic re-evaluation for the Neotropical species with molecular data. The high morphological conservatism within Orthostegana is largely the outcome of in situ diversification for adapting to the ecological environment.
The effect of site conditions and type of ramet clusters on sexual and asexual ramets of Solidago × niederederi (Asteraceae)
Authors: Pliszko Artur , Kostrakiewicz-Gierałt Kinga , Makuch-Pietraś Iwona
Published: June 2023

Spontaneous hybrids between alien and native plant species are alien taxa and they threaten native biodiversity due to their high competitive ability or introgression. Thus, we tested the effect of soil conditions, elevation and type of ramet clusters (clonal clumps of shoots) on sexual and asexual ramets of Solidago × niederederi, a hybrid between the invasive alien S. canadensis and the native S. virgaurea. We also tested the relationships between the size of sexual ramets and habitat conditions in the hybrid and its parental species, based on ten sites in NE and S Poland, respectively. The hybrid and its parental species occurred on mineral soils with a wide range of textures (sand, loamy sand, sandy loam, silty loam and loam) and pH (from strongly acidic to slightly alkaline). Sexual ramet clusters dominated in S. × niederederi populations, while the total number of ramets was highest in mixed ramet clusters. The cluster × site interaction had a significant effect on the length and biomass of sexual ramets in hybrid populations. Moreover, we found a significant effect of the taxon × site interaction in the case of biomass of sexual ramets and synflorescences (capitula arranged in panicles). Based on the biomass of sexual shoots and synflorescences, the competitive abilities of the hybrid may be more or less similar to S. canadensis or S. virgaurea albeit depending on site conditions.
La Russie doit perdre cette guerre
Authors: Littell Jonathan
Published: June 2023

Cet article se concentre sur le jeu de danse d’une petite fille de neuf ans, filmé par elle-même dans la cour d’une école primaire écossaise, en 2018. Olivia incorpore dans son jeu des objets numériques, non numériques, et son environnement, passant de la sélection de chansons sur un téléphone à la danse avec la caméra, au jeu avec le vent, et à la manipulation d’un cône de signalisation. Elle créé un espace de jeu personnel au milieu de l’espace commun, marqué par la musique, le mouvement, les objets et elle-même. Cet article examine comment, à travers ce processus de danse ludique, Olivia met en scène son enfance genrée au féminin, dans sa façon d’interagir avec les gens, l’espace et les objets. Olivia s’inscrit ainsi dans la tradition du jeu dansé des filles. Mais dans la cour post-numérique, les objets numériques deviennent une partie de son jeu, suivant une autre tradition enfantine du jeu, le “bricolage”, dans lequel les enfants utilisent le monde qui les entoure, à travers le temps et l’espace.
Enquêtes incognito en e-terrains sensibles : une éthique en eaux troubles ?
Authors: Renaut Laurène , Chevet Clotilde
Published: June 2023

Cet article propose une réflexion croisée sur deux ethnographies en ligne réalisées entre 2017 et 2020 : l’étude de djihadosphères d’une part et celle de groupes consacrés aux relations amoureuses et sexuelles homme-machine d’autre part. Derrière ces deux objets en apparence très éloignés émergent des problématiques communes tant liées à la production des connaissances qu’à leur restitution. Il s’agira d’abord de questionner le prix éthique d’une approche incognito, puis de cerner les enjeux d’une récolte clandestine de données sensibles, avant de présenter les stratégies mises en place pour restituer nos travaux de façon éthique et dès lors restreinte.
Tunisie : le modèle démocratique s’abîme
Authors: Mohsen-Finan Khadija
Published: June 2023

Suite au coup de force constitutionnel de juillet 2021, le président de la Tunisie Kaïs Saïed dispose de tous les pouvoirs, mais règne sur un pays en faillite et fait la chasse aux boucs émissaires.
En Israël, vers un coup d’État institutionnel ?
Authors: Bauchard Denis
Published: June 2023

Le gouvernement de Netanyahou, une coalition avec l’extrême droite religieuse, propose des mesures antidémocratiques, suscitant une crise politique qui a des conséquences sur les Palestiniens, ainsi que sur les relations d’Israël avec les États-Unis et les pays arabes.
La santé d’après
Authors: Bubien Yann , Dujin Anne
Published: June 2023

La pandémie de Covid-19 a placé la santé publique au cœur de nos sociétés en révélant une immense vulnérabilité collective, mais elle peine encore à se constituer en objet de débat public. Pourtant, des défis comme l’inégalité d’accès aux soins, la prévention sanitaire, la vocation des soignants, le réchauffement climatique ou le numérique, relèvent de choix collectifs. Ce dossier, coordonné par Yann Bubien, propose une approche globale et politique de la santé publique pour le XXI e  siècle.
Ce que les NEET font du recrutement digitalisé : conventions et pensée magique
Authors: Pralong Jean , Peretti-Ndiaye Marie
Published: June 2023

La digitalisation du recrutement est régulièrement présentée comme une solution au chômage des plus jeunes. Pourtant, les jeunes Français durablement éloignés de l’emploi (ou NEET : “ Neither in Employment, nor in Education or Training ” pour ni employé, ni étudiant ou en formation) représentent 20,2 % de leur tranche d’âge (18 à 26 ans). Dans cet article, nous proposons une analyse des comportements des jeunes chercheurs d’emploi confrontés aux pratiques de recrutement digitalisé. Un modèle d’analyse des pratiques est construit puis utilisé pour analyser les pratiques d’un groupe de jeunes diplômés éloignés durablement de l’emploi. Dans cette population au niveau de qualification élevé, l’effet du diplôme sur l’insertion est neutralisé, ce qui met en relief l’effet du recrutement lui-même. Les résultats indiquent que les candidats échouent à valider les conventions normatives en matière de recrutement. Cet échec et le maintien de pratiques inefficaces, comme la recherche d’un « CV exact », sont analysés comme les conséquences d’un rapport au savoir éloigné de celui du monde des affaires. La persistance dans l’échec conduit les jeunes interrogés à des registres de pensée inattendus dans l’univers technologique du recrutement digital : la chance et la pensée magique. Ces constats permettent de formuler des recommandations.
La compensation carbone des grandes entreprises est-elle du verdissement d’image ( greenwashing ) ?
Authors: Valiergue Alice
Published: June 2023

Cet article étudie les achats de services de compensation carbone de grandes entreprises. Alors que ces achats sont fréquemment associés à du verdissement d’image (ou en anglais greenwashing ), on observe pourtant de nombreuses entreprises qui investissent dans les services de compensation carbone. Pour comprendre ce paradoxe, l’article propose, à partir d’une enquête menée au niveau des acteurs chargés de la mise en œuvre de ces achats, de reconstituer le contexte organisationnel de travail des acteurs chargés de ces achats au sein des grandes entreprises, à savoir les directions développement durable. Une telle étude permet en effet d’expliquer l’essor de ces achats en montrant que les directions développement durable des grandes entreprises manquent de moyens pour mener leur mission, et que dans ce contexte, elles trouvent dans la compensation carbone des outils de management environnemental. L’article permet ainsi de renouveler les explications sur les politiques environnementales des entreprises, qui décrivent traditionnellement des changements macrosociologiques. Il montre ici l’apport analytique d’une étude menée au niveau de l’organisation.
Quels facteurs influencent les prises de décision dans le cadre de la Sclérose Latérale Amyotrophique au sein des membres de la triade patient, proches-aidants et soignants ?
Authors: Magdeleine Louise , Maziller Julie
Published: June 2023

Cette revue de la littérature traite de la Sclérose Latérale Amyotrophique et de la fin de vie des personnes atteintes. C’est au travers de l’Approche des Soins Fondés sur les Forces de Gottlieb que le rôle infirmier est développé. Dans le cadre de la Sclérose Latérale Amyotrophique, l’évolution rapide de la maladie, conduisant inévitablement au décès du patient, nécessite des prises de décisions afin de respecter les choix du malade. Cette pathologie entraine des déficits moteurs et cognitifs qui peuvent limiter l’autonomie du patient dans ses prises de décision. Ainsi, les proches-aidants et les soignants ont une part importante dans l’élaboration du projet de soin. L’objectif est d’étudier les différents facteurs qui influencent la prise de décision dans la triade patient, proche-aidants et soignants, en lien avec la Planification Anticipée du Projet Thérapeutique. Nous avons élaboré une équation de recherche à l’aide de la méthode PICO. Celle-ci nous a permis d’effectuer des recherches sur les bases de données PubMed et CINHAL et de trouver les six études qui composent notre revue de la littérature. Après lecture et analyse des articles sélectionnés, six thèmes au sujet des facteurs qui influencent les prises de décisions du point de vue des patients atteints de SLA, des proches et des professionnels de la santé ont émergé. Ces thèmes sont : moment opportun, besoin d’information, besoins et rôles des proches, communication, limites de l’autodétermination et expérience de la maladie. Les résultats ont ensuite été discutés et mis en lien avec l’Approche des Soins Fondés sur les Forces de Gottlieb. Au terme de ce travail, nous avons pu établir diverses recommandations en lien avec la pratique clinique, la recherche et l’enseignement.
Correlated storage assignment approach in warehouses: A systematic literature review
Authors: Islam Md. Saiful , Uddin Md. Kutub
Published: June 2023

Purpose: Correlation-based storage assignment approach has been intensively explored during the last three decades to improve the order picking efficiency. The purpose of this study is to present a comprehensive assessment of the literature about the state-of-the-art techniques used to solve correlated storage location assignment problems (CSLAP).Design/methodology/approach: A systematic literature review has been carried out based on content analysis to identify, select, analyze, and critically summarize all the studies available on CSLAP. This study begins with the selection of relevant keywords, and narrowing down the selected papers based on various criteria.Findings: Most correlated storage assignment problems are expressed as NP-hard integer programming models. The studies have revealed that CSLAP is evaluated with many approaches. The solution methods can be mainly categorized into heuristic approach, meta-heuristic approach, and data mining approach. With the advancement of computing power, researchers have taken up the challenge of solving more complex storage assignment problems. Furthermore, applications of the models developed are being tested on actual industry data to comprehend the efficiency of the models.Practical implications: The content of this article can be used as a guide to help practitioners and researchers to become adequately knowledgeable on CSLAP for their future work.Originality/value: Since there has been no recent state-of-the-art evaluation of CSLAP, this paper fills that need by systematizing and unifying recent work and identifying future research scopes.
LSTM projected layer neural network-based signal estimation and channel state estimator for OFDM wireless communication systems
Authors: Olickal Sebin J , Jose Renu
Published: June 2023

Advanced wireless communication technologies, such as 5G, are faced with significant challenges in accurately estimating the transmitted signal and characterizing the channel. One of the major obstacles is the interference caused by the delay spread, which results from receiving multiple signal copies through different paths. To mitigate this issue, the orthogonal frequency division modulation (OFDM) technique is often employed. Efficient signal detection and optimal channel estimation are crucial for enhancing the performance of multi-carrier wireless communication systems. To this end, this paper proposes a Long Short Term Memory-Projected Layer (LSTM-PL) deep neural network(DNN) based channel estimator to detect received OFDM signal. The results show that the LSTM-PL algorithm outperforms traditional methods such as Least Squares(LS), Minimum Mean Square Error (MMSE) and other LSTM deep learning channel estimation methods like Long Short Term Memory(LSTM)-DNN and Bidirectional-LSTM(Bi-LSTM)-DNN, as evidenced by Symbol-Error Rate (SER) outcomes.
Influenced node discovery in a temporal contact network based on common nodes
Authors: Huang Jinjing , Wang Xi
Published: June 2023

Verification is the only way to make sure if a node is influenced or not because of the uncertainty of information diffusion in the temporal contact network. In the previous methods, only $ N $ influenced nodes could be found for a given number of verifications $ N $. The target of discovering influenced nodes is to find more influenced nodes with the limited number of verifications. To tackle this difficult task, the common nodes on the temporal diffusion paths is proposed in this paper. We prove that if a node $ v $ is confirmed as the influenced node and there exist common nodes on the temporal diffusion paths from the initial node to the node $ v $, these common nodes can be regarded as the influenced nodes without verification. It means that it is possible to find more than $ N $ influenced nodes given $ N $ verifications. The common nodes idea is applied to search influenced nodes in the temporal contact network, and three algorithms are designed based on the idea in this paper. The experiments show that our algorithms can find more influenced nodes in the existence of common nodes.
A Neurological Complication in Rheumatoid Arthritis – A Scenario of Catastrophic Proportions
Authors: Varshney Megha , Ray Sucharita , Reddy Manod , Chatterjee Debajyoti , Chakravarty Kamalesh , Bhatia Vikas , Lal Vivek
Published: June 2023

Background:

Rheumatoid Arthritis (RA) is a common systemic inflammatory disease that can present with a plethora of extraarticular manifestations. Many patients with RA from low- and middle-income countries do not get timely and adequate treatment with disease-modifying therapies. This results in the perpetuation of a chronic inflammatory state.

Focus:

Rheumatoid vasculitis (RV) is one of the most aggressive complications of RA resulting from a prolonged proinflammatory milieu. Usually, it has the involvement of multiple organ systems, with cutaneous manifestations being the most common. Neurological presentation is uncommon but severe when present.

Highlight:

We present a case of severe RV presenting with an unexpected neurological complication consisting of cranial and peripheral neuropathy with small vessel disease and intracerebral haemorrhage. We intend to highlight the morbidity and long-term consequences of inadequately treated RA, the most common inflammatory disease of the connective system especially in light of the neurological presentation.
E2F8 Knockdown Suppresses Cell Proliferation and Induces Cell Cycle Arrest via Wnt/β-Catenin Pathway in Ovarian Cancer
Authors: Zhang Meiyin , Xu Ye , Zhang Yongjian , Lou Ge
Published: June 2023

Ovarian cancer is one of the leading causes of death in female reproductive system cancers. However, the pathogenesis of ovarian cancer remains elusive. Our aim is to investigate the potential targets for ovarian cancer. Two microarray datasets were obtained from the Gene Expression Omnibus public database. Using R package limma, the differentially expressed genes (DEGs) were identified from the datasets. There were 95 overlapping DEGs in two microarray datasets. GO, KEGG pathway analysis, and protein-protein interaction (PPI) network analysis were carried out based on the DEGs. Wnt signaling pathway and cell cycle were enriched in the KEGG pathway analysis. Moreover, the top 10 hub genes with the most nodes were determined by PPI network analysis. E2F8, one of hub genes was positively linked to a bad outcome in ovarian cancer patients. Furthermore, E2F8 knockdown suppressed cell proliferation and induced cell cycle arrest in ovarian cancer. In addition, we found that silencing E2F8 inhibited the Wnt/β-catenin signaling pathway. In ovarian cancer cells with E2F8 knockdown, overexpressing β-catenin restored both the suppressed capacity of cell proliferation and cell cycle progression. Therefore, our results revealed that E2F8 had an involvement in the development of ovarian cancer which might act as a therapeutic target.
Significance of Baseline and Changes of Tumor Markers and Neutrophil-to-Lymphocyte Ratio in Predicting Overall Survival for Patients with Advanced Pancreatic Adenocarcinoma: A Retrospective Analysis
Authors: Kadokura Makoto , Tanaka Keisuke , Amemiya Fumitake , Takano Shinichi , Fukasawa Mitsuharu , Enomoto Nobuyuki
Published: June 2023

Background:

The usefulness of various prognostic factors for pancreatic cancer has been reported, but limited studies have focused on these changes during chemotherapy. The purpose of the present study was to investigate the prognostic factors and to evaluate the significance of these changes during chemotherapy in patients with advanced pancreatic cancer (APC).

Materials and Methods:

We retrospectively analyzed 213 patients with APC who underwent chemotherapy between January 2006 and December 2018 at Kofu Municipal Hospital and University of Yamanashi Hospital. Univariate and multivariate cox regression models were applied to investigate independent prognostic factors.

Results:

Multivariate analysis revealed that Eastern Cooperative Oncology Group Performance Status 2 (hazard ratio [HR] 4.07, P < 0.01), neutrophil-to-lymphocyte ratio (NLR) ≥3.9 (HR 1.97, P < 0.001), modified Glasgow prognostic score 1–2 (HR 2.77, P < 0.001), carcinoembryonic antigen ≥5.0 (HR 1.44, P = 0.026), carbohydrate antigen 19-9 ≥37 (HR 1.83, P = 0.004), ΔNLR >0 (HR 2.01, P < 0.001), ΔCEA (subtracting the baseline from the start of second cycles of chemotherapy) >0 (HR 1.64, P = 0.002), and ΔCA19-9>0 (HR 1.77, P = 0.002) were independent negative prognostic factors.

Conclusion:

Baseline and change in tumor markers and NLR are useful in predicting overall survival in APC patients undergoing chemotherapy.
Inverse correlation of CD3 & vascular endothelial growth factor in incisional oral squamous cell carcinoma biopsies predicts nodal metastasis & poor survival of patients
Authors: Khan Wafa , Augustine Dominic , Rao Roopa S.
Published: June 2023

Background & objectives:

Oral squamous cell carcinoma (OSCC) is widely prevalent in the Indian subcontinent mainly due to habit-associated aetiologies. Immune regulation and angiogenesis are the part of tumourigenesis that play a crucial role in metastasis and survival. However, the concurrent expression of vascular endothelial growth factor (VEGF) and CD3 (immune regulator receptor on T-lymphocyte) in the same OSCC tissue samples has not been reported in the Indian population. The present study evaluated the expression of CD3+ T-cells and VEGF in OSCC tissue samples and studied the clinicopathological correlation and survival analysis in an Indian population.

Methods:

This was a retrospective study conducted on 30 formalin-fixed and paraffin embedded sections which were histologically diagnosed as OSCC cases comprising of 15 metastatic OSCC and 15 non-metastatic OSCC with available clinical data and survival status.

Results:

Reduced expression of CD3+ T-cells and increased VEGF expression were observed in metastatic OSCC samples. The correlation of expression of CD3+ T-cells and VEGF with clinicopathological parameters showed a significant association between these markers with age, nodal status, site of the lesion and survival.

Interpretation & conclusions:

Reduced expression of CD3+ T-cells in OSCC was found to be associated with a significantly poor survival. VEGF was found to be over expressed in metastatic OSCC as compared to that in non-metastatic OSCC. The study findings suggest that the evaluation of CD3 and VEGF in incisional OSCC biopsies can be considered for predicting the survival outcome and metastasis.
Non-invasive prenatal screening & diagnosis of β-thalassaemia in an affected foetus
Authors: Suwannakhon Narutchala , Hemvuthiphan Jittaphol , Pangeson Tanapat , Mahingsa Khwanruedee , Pingyod Arunee , Bumrungpakdee Wanwipa , Sanguansermsri Torpong
Published: June 2023

Background & objectives:

Non-invasive prenatal testing (NIPT) of maternally inherited alleles of β-thalassaemia (MIB) remains to be a challenge. Furthermore, current techniques are not available for use as routine tests. NIPT for β-thalassaemia disease was developed by using a specific droplet digital polymerase chain reaction (ddPCR) assay to analyze the cell-free foetal DNA (cffDNA) derived from maternal plasma.

Methods:

Pregnant women and their spouses who are at risk of bearing an offspring with β-thalassaemia disease from common MIB mutations (CD 41/42-TCTT, CD17A>T, IVS1-1G>T and CD26G>A) were enrolled. The ddPCR assay sets were constructed for each of the four mutations. All cell-free DNA samples were first screened for the paternally inherited β-thalassaemia (PIB) mutation. The PIB-negative samples were considered as non-disease and were not further analyzed. For PIB-positive samples, DNA fragments of 50-300 base pairs in size were isolated and purified, and further analyzed for MIB mutation. The allelic ratio between the mutant and the wild-type was used to determine the presence of MIB in cffDNA. All cases underwent a prenatal diagnosis by amniocentesis for a definite diagnosis.

Results:

Forty two couples at risk were enrolled. Twenty two samples were positive for PIBs. Among these 22 samples, there were 10 cases with allelic ratio >1.0 (MIB positive). All foetuses with over-represented mutant alleles were further diagnosed with β-thalassaemia disease; eight with compound heterozygous and two with homozygous mutations. The 20 PIB-negative and 12 MIB-negative foetuses were non-affected.

Interpretation & conclusions:

The results of this study suggest that NIPT utilizing the ddPCR assay can be effectively used for the screening and diagnosis of foetal β-thalassaemia in at risk pregnancies.
Ponseti Technique for CTEV: Our Experience at TMCH
Authors: Das Chinmoy , Das Partha Pratim , Gupta Navonil
Published: June 2023

Background and Objective:

Congenital talipes equinovarus (CTEV) also known as clubfoot is one of the common congenital orthopedic foot deformities in children. It is a complex deformity that is hard to correct, and the management is arguable and continues to be one of the significant challenges in pediatric orthopedics. It is believed that the initial treatment should be nonsurgical, which is started soon after birth within the first 2 weeks of life. We aimed to assess the efficacy of Ponseti’s technique for the treatment of CTEV in our institute for 6 years.

Materials and Methods:

One hundred eighty patients between 2 weeks and 12 years of age who had attended the CTEV clinic of the Department of Orthopaedics of our medical college in the last 6 years, until December 2020, were taken for the study to correct idiopathic CTEV using the Ponseti technique. Children included in the study were assessed every week before cast placement for the severity of the deformity using the Pirani scoring system. Once a week, manipulation and serial casting of the CTEV foot were started by the technique described by Ponseti. Patients were followed up at weekly intervals until forefoot and midfoot deformities were corrected. Percutaneous Achilles tenotomy was done to prevent rocker-bottom deformity and for correcting Equinus deformity after correction of other deformities. All patients were maintained on foot abduction brace after correction until 4 years of age or more.

Results:

At 6-month follow-up, Ponseti’s technique gave us 84.8% excellent results, 13.1% good results, and 2.1% poor results. A total of 86.6% required percutaneous tenotomy, whereas 13.4% did not require tenotomy.

Conclusion:

The Ponseti technique is still a safe, economical, and convenient treatment modality for CTEV, which gives successful results, and thus radically decreases the need for extensive corrective surgery even in older children.
Spontaneous psoas muscle haematoma due to antiplatelet treatment for stroke
Authors: Abdulla Mansoor
Published: June 2023

Spontaneous psoas muscle haematoma is a rare complication associated with bleeding diatheses such as anticoagulation, inherited coagulopathies and haemodialysis. An 80-year-old woman was admitted with a sudden onset of left sided weakness when she woke up from sleep. Magnetic resonance imaging of the brain revealed an infarct in the right occipital and left posterior parietal regions. She was started on aspirin 150 mg daily. She developed extensive purplish discolouration over the left lumbar region 5 days later. Contrast enhanced computed tomography of the abdomen showed left psoas muscle haematoma. The haematoma was managed conservatively and aspirin was discontinued. This case study describes this case, who developed spontaneous psoas haematoma (PH) after starting aspirin for stroke, which was managed conservatively. Only a few cases of spontaneous PH secondary to aspirin were previously reported.
Change in Left Ventricular Ejection Fraction after Transcatheter Aortic Valve Replacement in Severe Aortic Stenosis
Authors: Singh Shailesh , Khan Abdul Allam , Singh Katyayni
Published: June 2023

Background:

Long-standing aortic stenosis (AS) leads to elevated left ventricular (LV) pressure and as a consequence develops LV hypertrophy and increased myocardial fibrosis. The LV ejection fraction (LVEF) remains often preserved until the late stages of disease, but subtle LV dysfunction can be present in patients of severe AS. Transcatheter aortic valve replacement (TAVR) has become the primary method of aortic valve replacement for intermediate and high surgical risk patients with AS. In this study, we aimed to see if TAVR in patients with severe AS can result in the improvement of systolic functions.

Subjects and Methods:

We retrospectively studied the data of 52 consecutive symptomatic patients with severe symptomatic AS who underwent TAVR at our center. Echocardiography was performed at baseline and 6 months after the procedure to evaluate change in LVEF.

Results:

Fifty-two patients were retrospectively evaluated. The mean LVEF before TAVR was 49.52 ± 13.44. The mean LVEF after TAVR was 52.02 ± 10.95. That means there was a significant increase in LVEF after TAVR as compared to LVEF before TAVR (P = 0.008 using Wilcoxon signed-rank test).

Conclusion:

In this article, we conclude that, in AS patients, the removal of afterload by TAVR significantly improves cardiac functions as assessed by LVEF.
Vascular Anomalies in the Course and Branching Pattern of the Dorsalis Pedis Artery: A Case Report
Authors: Olonade Akinola Abraham , Tiryakioglu Mehtap
Published: June 2023

The dorsalis pedis artery (DPA) vascularizes most of the dorsum of the foot where it provides several branches. During a scheduled examination of the lower extremities of a male cadaver, a significant deviation was observed in the course and pattern of distribution of the left DPA. The artery trifurcated from its point of origin and was found to deviate from its normal course on the superior surface of the intermediate cuneiform, talus, and navicular bones. A lack of the arcuate artery was observed, and a varied branching pattern was established among the branches of the DPA on the dorsum of the foot. Knowing the detailed anatomy of the DPA and understanding its variability is of great clinical importance to surgeons, radiologists, and orthopedists due to the usefulness of this artery in different surgical interventions relating to the foot.
Effectiveness of Game-Based Learning: A Cross-Sectional Study on Phase 1 Medical Students
Authors: Pratheepa Sivasankari Natarajan , Sundarapandian Subramanian , Kalaivani Amitkumar , Anissa Joseph , Nithya Venugopal
Published: June 2023

Background:

In the past, teaching and learning methods mainly focused on content in knowledge rather than a learning experience. Nowadays, there has been an increased use of playful approaches to teaching and learning. Game-based learning (GBL) playfully engages with educational materials. We employed two game-based applications (Kahoot and Quizizz) and the traditional method of learning using multiple-choice questions (MCQs) and compared their efficacy in providing fun-based productive learning to medical students.

Methodology:

A cross-sectional study. Two hundred and fifty-two Phase 1 undergraduate medical students were included in the study. They were given three different assessment methods: paper-based MCQs, Quizizz, and Kahoot! Each method contained 10 questions. All students were encouraged to complete all three quiz methods. We conducted this study for 6 months. After 6 months, the students were given a questionnaire prepared on a Likert scale to evaluate students’ perception of concentration, engagement, enjoyment, and satisfaction of students.

Results:

P <0.05 indicated that there was a difference in average scores between the three methods (traditional quiz method, Quizizz, and Kahoot method). 96% of the students agreed that repeated attempts of doing the Quizizz in the app led to improvement in their long-term memory. The mean score of the student is highest in Kahoot! 53% of the students stated that image-based quiz was an interesting area. 92% of students felt that the live Quizizz was fun and interesting.

Conclusion:

A significant number of medical students enjoyed GBL since they can interact with one another and got motivated during the live Quizizz and Kahoot sessions. At the same time, students using the traditional method of learning were neither motivated nor enjoyed and hence we can utilize these game-based tools for teaching medicine and they can be used as a formative assessment tool too.
Best Washing Method for Oligoasthenospermic Patients by Evaluating DNA Integrity by using Comet Assay Study
Authors: Ganesan Balachandran Sivaraja , Govindarajan Sumathy
Published: June 2023

Background:

Sperm is more than just a mere transporter of paternal genetic information, although serving purposes other than conception. DNA integrity (DI) is regarded as a crucial aspect of semen quality and has great significance in predicting male fertility. Washing sperm is a form of preparation of sperm which is essential before processing intra-uterine-insemination since it removes chemicals from semen that might cause adversarial reactions in the uterus. During the process of washing, sperm gets separated from seminal fluid, which gradually improves the fertilizing capability of sperm, and numerous existing methods have faced complications with the determination of effective integrity in washing methods. The objective of the present study was to find the DI of the sperms through three washing methods that, include the density gradient (DG) method, swim up (SU) method, and magnetically activated cell sorting (MACS) method after the cryo-preservation (CP) for 3 months.

Methodology:

Semen samples were obtained from 40 oligoasthenospermic patients with progressive motility <32%, who underwent assisted reproductive technology procedure in Sumathi fertility center in Madurai between October 2021 and December 2021. Sperm washing is performed through three different mentioned techniques. The grades of the comet reflected five different classes from class 0 to class 4. These data were analyzed using one-way ANOVA test, and multiple comparisons were performed between these groups using Tukey’s test.

Results:

The results showed a high level of normal sperm (68%) in the DG method than the SU (47%) and MACS (42%) sperm preparation techniques that specified by significant elevation (P < 0.001) of class 0 comet tails.

Conclusion:

It was observed that the DG method has the best and success rates for intracytoplasmic sperm injection and in vitro fertilization was relatively high.
Management of gingival enlargement with orthodontic treatment- A case report
Authors: Sharma Vaishali Rai , Aggarwal Priyanka , Bali Shweta , Garg Amit , Nautiyal Aruna , Dedha Kajal
Published: June 2023

Gingival inflammation, fibrous outgrowth, or a combination of the two can result in gingival enlargement (GE), which has negative effects such as difficulties controlling plaque, difficulty chewing and speaking, as well as esthetic and psychological issues. Orthodontic treatment is one of the causes of gingival hypertrophy. A 20-year-old woman reported to the department of periodontics and oral implantology with a complaint of GE in relation to the front teeth. She was undergoing orthodontic treatment for treating tooth spacing in the anterior teeth. This article describes the treatment of this patient by gingivectomy to remove all extra gingival tissue. The fixed orthodontic treatment was continued with monthly periodontal checkups that were scheduled to control the gingival inflammation. The most crucial factor in successfully treating hyperplasia in patients receiving orthodontic treatment is teamwork between the periodontist and orthodontist.
Comparison of the outcome of diathermy versus scalpel skin incision in surgical cases
Authors: Khan Nida , Gupta Shalabh , Bhagat Tripta S.
Published: June 2023

Aim and Objectives:

The present study compared the outcome of diathermy versus scalpel skin incision in surgical cases.

Materials and Method:

The present Prospective interventional study was done at Santosh Medical College & Hospital for a period of 1.5 years. Group A included 100 patients treated with Scalpel and Group B included 100 patients treated with Diathermy.

Results:

The mean Incision time (s), Incision time (s/cm2) and Pain VRS score at day 1 and 2 was significantly more among Scalpel group compared to Diathermy group. The mean Blood loss in incision (ml) was significantly more among Diathermy group compared to Scalpel group.

Conclusion:

Due to shorter incision times, less blood loss, and less early postoperative discomfort, diathermy incisions have substantial benefits over scalpels in both elective and emergency general surgery.
Decoding stillbirths using relevant condition at death classification in a tertiary care hospital in North India
Authors: Agarwal Veenu , Agarwal Neelima
Published: June 2023

Objectives:

The objective of the study is to know the stillbirth rate and causes of stillbirth using relevant condition at death (ReCoDe) classification.

Methods:

A hospital-based retrospective study. The medical records of women with stillbirth between January 1, 2022, and March 31, 2023, were retrieved and analyzed for the cause of stillbirth using ReCoDe classification. The study was approved by institutional ethics committee.

Results:

There were a total of 4520 deliveries during the study and of these 78 were stillbirths, a rate of 17.2/1000 births. Maternal factors such as Pregnancy induced hypertension (PIH), preeclampsia and eclampsia, and undiagnosed congenital anomalies were significantly more common in un-booked mothers in the study subjects. Using ReCoDe classification the cause could be assigned to 88% of stillbirths. The most common maternal causes were PIH and antepartum hemorrhage while the most common fetal causes were severe growth retardation and lethal congenital anomalies. Medical conditions associated with stillbirths were found in 41.2% (32) mothers.

Conclusion:

ReCoDe classification is a useful, easy-to-use tool and can assign a cause to majority of stillbirths.
Rudimentary horn
Authors: Singh Anuradha , Puri Manju , Agrawal Swati , Saran Brijesh
Published: June 2023

A unicornuate uterus with a noncommunicating rudimentary horn is a rare uterine anomaly. The usual presentation is often asymptomatic; however, it can have catastrophic sequelae and long-term morbidity if not diagnosed. A case series of three cases with a varied clinical presentation of noncommunicating rudimentary horn was discussed. All cases had undergone a primary surgery, wherein the rudimentary horn was either unattended or undiagnosed, and later, they had to suffer with long-term morbidities due to complications related to noncommunicating rudimentary horn and had to undergo repeat surgery for definitive management. It should be routine for a surgeon to look for normal anatomy of the uterus and position of the uterine appendages, insertion of round ligaments in any pelvic surgery, and common operations like cesarean sections.
Complicated opioid withdrawal presenting with delirium
Authors: Beniwal Amit , Jamwal Aman Singh , Brar Tabish , Biswas Debalina , Saran Brijesh , Seth Amoolya K.
Published: June 2023

Unlike alcohol or benzodiazepine withdrawal, delirium is extremely uncommon during opioid withdrawal. We describe a case of smack addiction and opioid withdrawal in which led to delirium during withdrawal management. There is no prior history of substance misuse and no relevant personal or family background. It is discussed if delirium could be a withdrawal sign in opioid dependence. Yawning, sweating, lacrimation, rhinorrhea, anxiety, restlessness, insomnia, dilated pupils, piloerection, chills, tachycardia, hypertension, nausea/vomiting, crampy abdominal pains, diarrhea, and muscle aches and pains are some of the withdrawal symptoms that are typically associated with opioid abuse.
Doppler in threatened abortion
Authors: Gupta Manisha , Mishra Shubhangi , Agarwal Neelima
Published: June 2023

Threatened Abortion is one of the most common complication in early pregnancy. Its incidence varies between 20-25%. Transvaginal Color Doppler ultrasonography has permitted assessment of uteroplacental circulation in early pregnancy, irregularities of which have been linked to pregnancy complications such as hypertension, fetal growth restriction (FGR), fetal distress, and early pregnancy failure). The capability of trans-vaginal Doppler sonography to analyze the pattern of circulation in even terminal branches of the uteroplacental circulation has encouraged research for its potential use in predicting early and late pregnancy complications related to abnormal placentation. Impaired vascular remodelling in the maternal - fetal interface is one of the most significant factors associated with early and late complications in pregnancy.