bluuebunny/crossref_metadata_2025 huggingface dataset:
Downregulation of miR-142-3p Contributes to Breast Cancer Oncogenesis
Authors: WANG Gangping , WANG Gangping , Shi Huifang , Li Jingjing , Chen Lei , Yang Shuguang , Zhao Ying , Zhang Zuofeng
Published: December 2019

Breast cancer is one of the commonly-encountered malignant tumors, and its morbidity is on the rise year
by year. A better understanding of the molecular mechanisms of breast cancer is important. This can
improve the prevention, diagnosis, and treatment.The miR-142‐3p has been shown to inhibit carcinogenesis
by regulating various cellular processes, including cell cycle progression, cell migration, apoptosis, and
invasion. We surgically recruited 96 breast cancer patients and the breast cancer samples, each with matched
adjacent normal breast tissue were obtained, MDA-MB-231 and MCF-7 cells were cultured for experiments
in vitro and measured the expression of miR‐142‐3p via quantitative real‐time polymerase chain reaction
(qRT‐PCR). Cell viability, apoptosis, migration, and invasion were determined by MTT, flow cytometry,
and trans-well assays. The expression of miR-142-3p was down-regulated in both cancer cell lines and
cancer specimens. The reduced expression of miR-142‐3p was associated with tumor size, lymph node
metastasis, and tumor-node-metastasis (TNM) stage of patients (p<0.05). However, there was no significant
correlation between miR‐142‐3p expression in tumor tissues with age at diagnosis (p>0.05). Overexpression
of miR-142-3p repressed cell viability, migration, and invasion, while it induced apoptosis, whereas its
depletion promoted it. The results suggest miR‐142‐3p acts as a tumor suppressor and can act as a novel
target for the treatment of breast cancer. Thus, restoration of miR‐142‐3p expression, for example, via
miRNA replacement therapy, may represent an effective strategy for the treatment of breast cancer patients
THERAPEUTIC JURISPRUDENCE: PRÁTICAS JURÍDICAS A PARTIR DA ÉTICA DO CUIDADO
Authors: Bertotti Iziane Luiza , Battisti Fernando
Published: December 2019

A atividade jurídica/processual por vezes é realizada somente por atos formais e sequenciais, sem a observância da humanização das relações interpessoais na busca da pacificação social, finalidade esta da aplicação do Direito. Nesse sentido, é necessário pensar a atividade jurídica de forma humanizada sob o viés da ética do cuidado, a qual possibilita um olhar reflexivo do âmbito jurídico no tocante às influências no meio social que a prática jurídica provoca. Assim, a doutrina da Therapeutic Jurisprudence (“TJ”) apresenta-se como proposta pertinente ao cenário jurídico contemporâneo marcado por uma necessidade de sua humanização, seja no âmbito processual, da legislação, dos agentes que atuam na prática forense e das práticas alternativas de solução de conflitos. Dessa forma, o presente estudo busca problematizar a aplicação da atividade jurídica sob o viés do cuidar e analisar a materialização da “TJ” na esfera penal através do método APAC - Associação de Proteção e Assistência aos Condenados, tendo em vista a necessidade de humanizar a pena privativa de liberdade na busca da ressocialização e reintegração social dos apenados. O presente trabalho acadêmico faz parte do grupo de estudos em Therapeutic Jurisprudence do curso de Direito da URI Campus de Frederico Westphalen/RS, sendo desenvolvido por método dedutivo e dialógico, através de pesquisa bibliográfica e documental por meio de leituras e sintetização de livros, artigos científicos e textos publicados na internet, uma vez que há pouca doutrina que versa sobre o método APAC e sobre a prática da “TJ”.
Detection of Active Plaques in Multiple Sclerosis Using 3 and 12 Directional Diffusion-weighted Imaging: Comparison with Gadolinium-enhanced MR Imaging
Authors: Rahimi S , Azari A , Ghaemmaghami P , Meftahi G H , Pirzad Jahromi G
Published: December 2019

Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by exacerbations of neurological dysfunction due to inflammatory demyelination. MRI is the most sensitive method to make adiagnosis of multiple sclerosis. contrast-enhanced T1-weighted imaging (CE T1WI) is used as a gold standard to distinguish active and inactive MS lesions. However, Gadolinium based contrast agents (GBCAs) have some contraindications. Diffusion-weighted imaging (DWI) can detect diffusion alterations in active inflammatory lesions. The purpose of this study is to investigate whether common DWI (3 directional) and 12 directional DWI which is used in Diffusion tensor imaging can be an alternative to CE T1WI so as to demonstrat active (enhanced) MS lesions.Methods: In this cross sectional study, at two different hospitals, 138 patients who presented with CNS symptoms suggestive of demyelinating disease were examined. CE T1WI using 0.1 mmol/kg gadolinium as well as 3 & 12 directional DWI was done for all patients. To determine the reliability and accuracy of 3 & 12 directional DWI for delineating the enhancement of demyelinating lesions on CET1W, Intraclass correlation coefficient (ICC) and the plot of sensitivity versus specifity is called receiver operating characteristic (ROC) curve and the area under the curve (AUC) were calculated.Results: 114 patients (82.6%)revealed  contrast enhancement in CE T1WI, 117 (84.7%) and 107 (77.5%) patients demonstrated hyper intense lesions on DWI 12 & DWI 3 respectively. The intraclass correlation coefficient (ICC) for DWI 12 was higher than 0.92; however, for DWI 3 was less than 0.64. The DWI 12 data generated a sensitivity and specificity of 94.7% and 62.5%, combined with an AUC of 84%. Besides the sensitivity, specificity and AUC for DWI 3 CE were 86%, 62.5 and 79%, respectively.Conclusion: Among 2 different DWI sequences, 12 directional DWI images have higher reliability and accuracy. Therefore, despite lower sensitivity compared to CE T1WI, it can be a practical diagnostic sequence in discriminating enhancing lesions from non-enhancing lesions when performing CE-MRI is a concern for the patient. concerning the cons and pros of CE T1WI and DWI 12, these two sequences can be used in combination in order to reach higher sensitivities, leading to earlier diagnosis and more cost effective treatment.
Reviewing for Interdisciplinary and Broad-Scope Journals
Authors: Abrams Benjamin
Published: December 2019

If there is a single academic craft that is most sorely neglected in doctoral programs, most infrequently honed over the course of one’s career, and most inconsistently exhibited at the top ranks of the academy, it is the practice of reviewing an article. Reflecting on conversations with editorial colleagues at Contention and other broad-scope journals, this essay draws together some brief guidelines on how best to compose the three most basic components of any academic review: criticism, praise, and recommendations to the editor.
SYNERGISTIC EFFECT OF QUERCETIN AND EPIGALLOCATECHIN-3-GALLATE AS AGENTS TO PREVENT CONNECTIVE TISSUE DISINTEGRATION IN THE PERIODONTIUM OF RATS UNDER SYSTEMIC AND LOCAL ADMINISTRATION OF LIPOPOLISACCHARIDE OF SALMONELLA TYPHI
Authors: Yelins’ka A.M. , Kostenko V.O.
Published: December 2019

The aim of the present study was to investigate the co-effect produced by water-soluble form of quercetin and epigallocatechin-3-gallate (EGCG) on biochemical markers of periodontal organic matrix depolimerization under systemic administration and local application of S. typhi lipopolisaccharide (LPS). The studies were conducted on 30 white rats of the Wistar line weighing 180-220 g, divided into 5 groups: the 1st included intact animals, the 2nd was made up of animals after the combined systemic and local LPS administration, the 3rd and 4th groups included animals, which were being given injections with water-soluble form of quercetin (10 mg / kg) and EGCG (21.1 mg / kg) respectively 3 times a week, starting on the 30th day of the systemic LPS administration, and the 5th group involved rats, which were injected with co-administered water-soluble form of quercetin and EGCG. It has been found out that the co-effect produced by quercetin and EGCG under systemic and local LPS administration is accompanied with reduced concentration of N-acetylneuraminic acid (NANA) by 31.8 and 32.8% respectively in the soft periodontal tissues compared with values for the animals received separate quercetin and EGCG during the experiment. However, no differences have been detected between the groups exposed to combined or separate action of the above mentioned agents in the experiment when assessing free hydroxyproline (FHP) and glycosaminoglycans (GAGs) content in the soft tissues of periodontium. At the same time combined use of quercetin and EGCG under experimental conditions led to the decrease in the FHP content in the alveolar bone by 24.5 and 20.2% respectively compared with values for the animals received separate quercetin and EGCG. NANA concentration was reduced by 35.0 and 41.3% respectively. Thus, the co-administration of water-soluble form of quercetin and epigallocatechin-3-gallate under systemic and local introducing of S. typhi lipopolysaccharide has been proven to be more effective means for preventing and correcting periodontal connective tissue disruption than this occurs at separate administration of each of the polyphenols.
An effect-theoretic reconstruction of quantum theory
Authors: Wetering John van de
Published: December 2019

An often used model for quantum theory is to associate to every physical system a C∗-algebra. From a physical point of view it is unclear why operator algebras would form a good description of nature. In this paper, we find a set of physically meaningful assumptions such that any physical theory satisfying these assumptions must embed into the category of finite-dimensional C∗-algebras. These assumptions were originally introduced in the setting of effectus theory, a categorical logical framework generalizing classical and quantum logic. As these assumptions have a physical interpretation, this motivates the usage of operator algebras as a model for quantum theory.In contrast to other reconstructions of quantum theory, we do not start with the framework of generalized probabilistic theories and instead use effect theories where no convex structure and no tensor product needs to be present. The lack of this structure in effectus theory has led to a different notion of pure maps. A map in an effectus is pure when it is a composition of a compression and a filter. These maps satisfy particular universal properties and respectively correspond to `forgetting' and `measuring' the validity of an effect.We define a pure effect theory (PET) to be an effect theory where the pure maps form a dagger-category and filters and compressions are adjoint. We show that any convex finite-dimensional PET must embed into the category of Euclidean Jordan algebras. Moreover, if the PET also has monoidal structure, then we show that it must embed into either the category of real or complex C∗-algebras, which completes our reconstruction.
Uncovering Vulnerabilities and Resilience of Benghazi After the War
Authors: BARANİ Abdelhamed , KAHRAMAN Zerrin Ezgi
Published: December 2019

that they not only stimulate vulnerabilities of
cities but also decrease their resilience. The civil war in the city of
Benghazi stared in 2011. This study aims to investigate both the multifaceted
vulnerabilities of Benghazi resulted from war and some signs of resilience
reactions against consequences of war. It attempts to compare before and after
the war situations for various structures in the city including demographic,
economic, social, spatial and environmental dimensions. To do this, it analyses
written and visual documents such as master plans, satellite images and
national/international reports. The study finds outs that the inhabitants of
the city have economically developed resiliency strategies by creating new jobs.
Moreover, the residents of Benghazi construct permeant or temporary houses at
the outskirts of the city as a spatial resiliency reaction. However, this
reaction results in urban sprawl in the city which consequently stir up the pressures
on natural environmental in the city.(Ballentine & Nitzschke, 2005; Brzoska &
Fröhlich, 2016)Wars result in the
destruction of cities in many ways
行政事业单位预算绩效管理
Authors: 许 伟成
Published: December 2019

预算绩效管理对行政事业单位有着积极作用,对行政事业单位的资源进行合理科学分配,而且还能提升资金的使用效率,同时也能促进行政事业单位预算管理工作。但是,行政事业单位预算绩效管理的过程中,还存在一些问题需要解决,本文对此进行了分析。
LAMA RAWAT PADA PASIEN DENGAN CEDERA KEPALA RINGAN
Authors: Amila Amila , Sariani Sariani
Published: December 2019

ABSTRACT : LENGTH OF STAY MILD HEAD INJURY IN SARI MUTIARA GENERAL HOSPITAL Background : Early management of  head injury patient in hospital will affect the outcome and length of stay mild head injury patient in the hospital.Purpose : The purpose of this study were to identify the correlation among age, GCS  and hyperglycemia with length of stay in the hospital.Methods :The data obtained was analyzed by correlational analytic with retrospective approach. The sample of this study was recruited with consecutive sampling as 117 people. Data collected by observation from medical record on the mild head injury patients who come to hospital from March 2014 until March 2015 at Sari Mutiara General Hospital Medan. The data was analyzed by pearson and spearman correlation  with significance α <0.05.Results : The study showed that  70.1%  Hyperglicemia, mean of age, GCS and length of stay were 32.09; 13,99 and 3.68 in mild head injury.There was no significantly correlation between age with length of stay (r = 0.163; p > 0.05). Whereas there was significant correlation between GCS and hyperglycemia with length of stay (r=-0.735; r = 0.610 ; p < 0.05)Conclusion : Based on the study, we concluded that the more hyperglycemia, the more severe length of stay in patient with mild head injury.  Keywords: Mild head injury; GCS; Hyperglycemia; Length of stayPendahuluan: Penanganan awal pasien cedera kepala pada saat datang ke rumah sakit akan mempengaruhi outcome serta Length of Stay (LOS) pasien di rumah sakitTujuan : Penelitian ini bertujuan untuk mengetahui hubungan umur, GCS dan hiperglikemia dengan LOS pasien cedera kepala ringan di RSU Sari Mutiara Medan.Metode : Metode penelitian dilakukan secara analitik korelasional dengan pendekatan retrospektif. Teknik sampling dalam penelitian ini menggunakan consecutive sampling dengan jumlah sampel sebanyak 117 orang  yang diambil dari data sekunder yaitu observasi pada catatan medis pasien cedera kepala ringan yang dirawat di RSU Sari Mutiara Medan dalam periode satu tahun (Maret 2014 s.d Maret 2015). Data dianalisis menggunakan uji korelasi Pearson dan Spearman dengan signifikan α <0.05.Hasil Penelitian: Hasil uji menunjukkan 70.1% pasien hiperglikemia, rata-rata umur pasien  adalah 32.09 tahun, rata-rata GCS dan lama rawat pasien cedera kepala ringan adalah 13,99 dan 3.68 hari. Hasil uji menunjukkan tidak ada hubungan antara umur dengan LOS pasien cedera kepala ringan dengan nilai p=0,080 dengan kekuatan korelasi r = 0,163. Hasil uji didapatkan hubungan yang signifikan antara GCS dan hiperglikemia dengan LOS pasien cedera kepala ringan (p=0,000) dengan kekuatan korelasi (r=-0.735; r= 0,610).Simpulan : Hal ini menunjukkan bahwa semakin tinggi hiperglikemia, maka semakin tinggi LOS pasien cedera kepala.
PERBEDAAN FAKTOR RISIKO DAN PERILAKU DETEKSI DINI KANKER SERVIKS PADA WANITA USIA SUBUR ANTARA WILAYAH PARUNGKUDA DENGAN PALABUHANRATU
Authors: Yuliani Vini
Published: December 2019

mencari perbedaan faktor risiko dan perilaku deteksi dini kanker serviks pada wanita usia subur antara puskesmas parungkuda dengan palabuhanratu
PENGETAHUAN IBU TENTANG PENYAKIT PNEUMONIA PADA BALITA
Authors: Linawati Linawati , Siahaan Edita Revine , Warina Elda , Yulendasari Rika
Published: December 2019

ABSTRAKData dari Puskesmas Mulya Asri didapatkan bahwa tahun 2015 jumlah persentase angka kejadian Pneumonia pada balita sebesar 20.31% (50 balita), dan 3 (5.6%) diantaranya harus dirujuk ke RS, dan merupakan Puskesmas dengan kasus pneumonia tertinggi di Kabupaten Tulang Bawang Barat. Tujuan penelitian ini diketahui perbedaan pengetahuan ibu sebelum dan sesudah dilakukan pendidikan kesehatan tentang penyakit Pneumonia pada Balita di Puskesmas Mulya Asri Kabupaten Tulang Bawang Barat Tahun 2017.Jenis penelitian kuantitatif dengan rancangan pra eksperimen dengan pendekatan one group pra-post test design. Populasi penelitian adalah semua ibu yang memiliki balita di Puskesmas Mulya Asri Kabupaten Tulang Bawang Barat sejumlah 2.922 orang dengan sampel 20 responden. Instrumen pengumpulan data  menggunakan kuesioner. Analisa statistik yang digunakan uji t-dependenHasil penelitian menunjukkan nilai rata-rata berdasarkan pengetahuan sebelum dilakukan pendidikan kesehatan adalah 60,2 dengan standar deviasi 10,1.  Nilai rata-rata pengetahuan setelah dilakukan pendidikan kesehatan adalah 72,2 dengan standar deviasi 7,5. Ada perbedaan pengetahuan ibu sebelum dan sesudah dilakukan pendidikan kesehatan tentang penyakit Pneumonia pada Balita di Puskesmas Mulya Asri Kabupaten Tulang Bawang Barat Tahun 2017 (P value=0,000). Saran dalam penelitian diharapkan dapat melakukan kegiatan pendidikan kesehatan dan pencegahan serta penanganan dan perawatan balita Pneumonia dengan menggunakan metode ceramah disertai pemutaran VCD. Kata Kunci          : Pengetahuan, Pneumonia, Pendidikan Kesehatan
Sentimen Investor Dan Three-Factor Asset Pricing Model (Studi Empirik Di Bursa Efek Indonesia)
Authors: Wendy Ary William
Published: December 2019

Penelitian ini menginvestigasi peranan sentimen investor terhadap return industri beserta implikasinya pada three-factor asset pricing model. Peranan sentimen investor pada penelitian ini diukur menggunakan proksi indeks keyakinan konsumen (IKK). Penelitian ini menggunakan data bulanan dari Januari 2013 sampai Desember 2017. Hasil penelitian ini membuktikan bahwa sentimen investor berpengaruh negatif terhadap return industri terutama pada sektor properti, real estate, dan konstruksi bangunan dan sektor keuangan, serta membuktikan pengaruh sentiment investor yang signifikan pada model asset pricing, khususnya three-factor asset pricing model. Secara garis besar, peranan sentimen investor yang signifikan tersebut menunjukkan adanya fenomena mispricing dalam melakukan penilaian harga aset di Pasar Modal Indonesia.
Pengaruh Profitabilitas Dan Kecukupan Modal Terhadap Nilai Perusahaan Dengan Islamic Social Report (Isr) Sebagai Variabel Moderasi (Studi Pada Bank Umum Syariah Indonesia Tahun 2014-2018)
Authors: Sulistiyo Fauzi , Yuliana Indah
Published: December 2019

Penelitian ini bertujuan untuk menguji dan mengetahui faktor yang mempengaruhi nilai perusahaan pada bank umum syariah di Indonesia. Faktor yang dianalisis dalam penelitian ini adalah profitabilitas, kecukupan modal, dan Islamic Social Report (ISR). Populasi dalam penelitian ini adalah 14 Bank Umum Syariah Indonesia. Sampel dalam penelitian ini yaitu 8 Bank Umum Syariah Indonesia yang telah memenuhi kriteria selama periode 2014-2018. Teknik pengambilan sampel yang digunakan d adalah purposive sampling. Metode dalam penelitian ini menggunakan uji statistik deskriptif, uji asumsi klasik, uji regresi berganda dan uji moderasi. Berdasarkan hasil pengujian hipotesis dapat disimpulkan bahwa profitabilitas, kecukupan modal, dan Islamic Social Report (ISR) berpengaruh positif terhadap nilai perusahaan. Kemudian Islamic Social Report (ISR) mampu memoderasi hubungan antara profitabilitas dan kecukupan modal terhadap nilai perusahaan.
Justification of the effect of transitional modes on the quality of ready-made products when their treatment is used by plastic deformation methods from the position of the wave and auto vibration processes
Authors: Uchitel A. D. , Malinovskyi Yu. A. , Panchenko A. N. , Danilina G. V. , Datsenko S. Yu.
Published: December 2019

Purpose. Substantiation of the role of longitudinal and transverse wave processes in the surface layers on the quality of finished products obtained by plastic deformation methods, such as cold rolling, stamping, running in, drawing and others.
Research methodology. In the work, to describe the transients at the beginning of the interaction of the tool with the workpiece, a computational model was applied in which the surface layers of the workpiece are represented as a beam on an elastic base, loaded with suddenly applied tangential forces, often exceeding their critical values. The reasons for the occurrence of unstable dynamic states of such a beam, in which the integrity of the surface layers of the workpiece and parts may be disturbed due to the occurrence of supercritical stresses and deformation in the material of the outer layers, are investigated.
Findings. The results were obtained on the definition of hazardous states of the surface layers of the workpiece, under the action of suddenly applied loads at the initial moments of the capture of the workpiece, as well as at the moments when the tool slips over the workpiece during the alignment of their speeds.
Originality. It consists in the fact that the first dynamic problem was set and solved for the surface layers of the workpiece, represented as a two-support beam on an elastic base loaded with a suddenly applied longitudinal force, which can significantly exceed its critical value. Denoted areas of dynamic instability of the surface layers of the workpiece.
The practical value of the work lies in the fact that the modes of operation of the metal forming machine and the parameters of the workpiece were identified under which conditions for obtaining products of insufficient quality may arise. As well as developed recommendations for improving the quality of finished products.
Key words: metal forming, transients, longitudinal wave, shear wave, billet, loaded layer, overload coefficient, dynamic buckling, tool, rolling, knurling, drawing, hypothetical beam, impact, elastic wave propagation velocity.
A Critical Approach to Digital Pedagogy - A Holistic Methodology in the Information Society
Authors: Szűts Zoltán
Published: December 2019

In the present, the use of info-communication technology has become a living communication reality that pervades everyday life. The relationship between the learning and teaching process to medialization and digital technology has become increasingly prominent. Since the spread of digital data, and especially the emergence of the World Wide Web, many phenomena and trends and could have been observed regarding the use of ICT in education. Some of these trends have reached on theirpeak the plateau of productivity since the 1990s, but more have proven to be merely fad. One of the most frequently used methods in the present is, for example, the flipped classroom, where students acquire the theory at home through digital curricula, while in the classroom they deepen their knowledge and interact with teachers. From the 2000s, e-learning has become a new educational environment which includes novel forms of learning and teaching supported by ICT, both in form,content, and methodology. In the present, E-learning continues to be a significant trend, and many teachers are just now discovering the benefits of the platform and some of them turn to blended learning (Kis-Tóth – Lengyelné, 2012).The use of a Learning Management Systems (LMS) relies on multimedia and linking texts - hypertext - while it requires interaction between the learner (user) and the text (information). Gamification supports the player within, where point systems, levels, and healthy competition between students play an essential role. Although not a traditional methodology, the use of social media and web 2.0 in education is becoming more and more important, students follow or write blogs, or edit Wikipedia. As it is observed that nowadays students’ attention can be maintained for a shorter period then in the case of previous generations, the use of micro-content in the transfer of knowledge adapts to the accelerated information-taking habits. In the universe of micro-content, the use of smaller curricula reinforces thepopularity of independent learning. Finally, current trends include the strengthening of the interactive visual learning environment, (Benedek, 2019) and the use of augmented reality content, or how Microsoft refers to it, mixed reality.The lesson of the past 30 years might be that using technology itself, without a sophisticated methodology that takes into account as many didactic aspects is not enough. The technology-centered approach teaching-learning process is just as much a mistake as the thinking that automatically assumes the effectiveness of learning organization due to the use of modern technology. Any methodology in which the demonstration is given prominence describes that its application, if unrelated to the process, can very easily become a dead end. The use of technology, unless it is based on methodological principles, does not lead to an increase in the efficiency of the learning process. By focusing merely on the application of technology, unrealistic expectations cannot be met.” (Ollé, 2013: 102.)
Modeling of Short P-Channel Symmetric Double-Gate MOSFET for Low Power Circuit Simulation
Authors: Ahmed Rekib Uddin , Saha Prabir
Published: December 2019

In the present era, down scaling of complementary metal-oxide-semiconductor (CMOS) technology has lead the metal-oxide-semiconductor field-effect-transistor's (MOSFET) sizes to nanometer regime which in turn experiencing difficulties due to the effect of physical and technological perspective. Double-gate (DG) MOSFET is considered as a promising device to reduce the shortcoming and shrink down towards nanometer domain. This paper proposes electrostatic potential distribution and drain current models for the lightly doped symmetrical p-channel DG MOSFET. The analytic solution of potential distribution is derived by solving the 2D Poisson's equation incorporated with hole density through the superposition method. The drain current model has been explored by incorporating physical effects like threshold-voltage roll-off, channel length modulation and surface roughness scattering. Functionality of the models has been calculated in MATLAB and the obtained results are verified and compared with state of the art literature.
Integrated Thermal Management in System-on-Package Devices
Authors: Bognár György , Takács Gábor , Szabó Péter G. , Rózsás Gábor , Pohl László , Plesz Balázs
Published: December 2019

Thanks to the System-on-Package technology (SoP) the integration of different elements into a single package was enabled. However, from the thermal point of view the heat removal path in modern packaging technologies (FCBGA) goes through several layers of thermal interface material (TIM) that together with the package material create a relatively high thermal resistance which may lead to elevated chip temperature which causes functional error or other malfunctions. In our concept, we overcome this problem by creating integrated microfluidic channel based heat sink structures that can be used for cooling the high heat dissipation semiconductor devices (e.g.: processors, high power transistor or concentrated solar cells). These microchannel cooling assemblies can be integrated into the backside of the substrate of the semiconductor devices or into the system assemblies in SoP technology. In addition to the realization of the novel CMOS compatible microscale cooling device we have developed precise and valid measurement methodology, simulation cases studies and a unique compact model that can be added to numerical simulators as an external node. In this paper the achievements of a larger research are summarized as it required the cooperation of several experts in their fields to fulfil the goal of creating a state-of-the-art demonstrator.
Thanks to the System-on-Package technology (SoP) the integration of different elements into a single package was enabled. However, from the thermal point of view the heat removal path in modern packaging technologies (FCBGA) goes through several layers of thermal interface material (TIM) that together with the package material create a relatively high thermal resistance which may lead to elevated chip temperature which causes functional error or other malfunctions. In our concept, we overcome this problem by creating integrated microfluidic channel based heat sink structures that can be used for cooling the high heat dissipation semiconductor devices (e.g.: processors, high power transistor or concentrated solar cells). These microchannel cooling assemblies can be integrated into the backside of the substrate of the semiconductor devices or into the system assemblies in SoP technology. In addition to the realization of the novel CMOS compatible microscale cooling device we have developed precise and valid measurement methodology, simulation cases studies and a unique compact model that can be added to numerical simulators as an external node. In this paper the achievements of a larger research are summarized as it required the cooperation of several experts in their fields to fulfil the goal of creating a state-of-the-art demonstrator.
Hey You! Irak’taki Amerikan Hapishanelerinden Hatıralar
Authors: KOÇ Mehmet Akif
Published: December 2019

20 Mart 2003 tarihi, Ortadoğu’nun son
yıllarını şekillendiren en önemli hadiselerden birinin, Irak'ın ABD ve müttefikleri tarafından işgalinin başlangıcıdır. 2003 işgali sonrasında projektörlerin
en fazla üzerine tutulduğu bölge ülkesi ise İran oldu; İranlı siyaset/kültür
çevrelerinde Irak’ın kadimden beri İran kültür zemini içinde değerlendirilmesi
ve İran’ın jeopolitik algılamasında Irak’ın işgal ettiği merkezi konum, 1980-88
yılları arasında yüzbinlerce insanın hayatını kaybettiği yıpratıcı savaş ve
Irak nüfusunun yaklaşık 2/3’ünün Şiilerden oluşması da bunda etkili oldu. Bu açıdan,
Irak işgalini, bilhassa ilk dönemi itibariyle ele alıp inceleyen İranlı birinci
el kaynakların tetkik edilmesi, İran’ın bölgedeki ABD siyasetini nasıl
algıladığını ve Irak’taki dini/siyasi çevrelere bakışını yakından görebilmek
açısından önem taşımaktadır. Said
Ebutalib’in 2013 yılında hazırladığı Hey You! Irak’taki
Amerikan Hapishanelerinden Hatıralar – Yarım Kalmış Bir Belgeselin Hikayesi
başlıklı gözlem ve hatırat kitabı, bu çerçevede değerlendirilebilecek önemli
bir ilk el tanıklık olarak dikkat çekmektedir.
Tuoreita avauksia graduntekijöiltä
Authors: Kouvo Terhi
Published: December 2019

Ansiokkaista opinnäytetöistä palkittiin Yuan Wang Joensuusta ja Liisa Nyblom Tampereelta.
Avoimesti suomeksi – mahdoton yhtälö?
Authors: Silvennoinen Heikki
Published: December 2019

Opetus-­ ja kulttuuriministeriö on virittänyt tutkijoille oravanpyörän, jonka vauhtia tutkimuksen tekijät itse eivät voi kohtuullistaa.
”Kuinka tukea aikuisia kestävän tulevaisuuden rakentajina?”
Authors: Laakkonen Erja
Published: December 2019

Joensuulaista tukijaa Toni Kososta, 37, kiinnostavat erityisesti aikuisten ohjauksen kysymykset.
Age, Sex, and Repeated Measures Effects on NASA’s “Cognition” Test Battery in STEM Educated Adults
Authors: Lee Grace , Moore Tyler M. , Basner Mathias , Nasrini Jad , Roalf David R. , Ruparel Kosha , Port Allison M. , Dinges David F. , Gur Ruben C.
Published: December 2019

BACKGROUND: Cognition is a neurocognitive test battery created at the University of Pennsylvania and adapted by the National Aeronautics and Space Administration (NASA). It comprises 10 neurocognitive tests that examine multiple domains, and has been validated in a normative
sample of STEM-educated adults and compared to NASA’s WinSCAT battery.METHODS: The purpose of this study was to follow the original sample to assess Cognition and WinSCAT’s test-retest reliability and age, sex, and test-retest interval effects on performance.RESULTS:
Performance on both Cognition and WinSCAT decreased with age but improved with repeated administration due to practice effects, and men had higher scores than women on tasks that required vigilant attention, spatial reasoning, and risk-taking behaviors. Assessment of test-retest reliability
showed intraclass coefficients for efficiency ranging from 0.417 to 0.810, reflecting the broad nature of constructs assessed by Cognition.DISCUSSION: Results largely matched predictions, with some counter-intuitive results for test-retest reliability interval.Lee G, Moore
TM, Basner M, Nasrini J, Roalf DR, Ruparel K, Port AM, Dinges DF, Gur RC. Age, sex, and repeated measures effects on NASA’s “Cognition” Test Battery in STEM educated adults. Aerosp Med Hum Perform. 2020; 91(1):18–25.
Migraine History and Recurrence in Military Pilot Applicants
Authors: Hesselbrock Roger R. , Haynes Jared T.
Published: December 2019

BACKGROUND: Migraine is a common condition with features that can adversely impact aviation activities. The diagnosis of migraine is often compatible with civil aviation training, but is much more concerning for military pilot applicants. A history of migraine headache traditionally
medically excluded potential military pilot applicants due to unpredictability of occurrence and potential for operational distraction or incapacitation. Medical standards and policy applications have been quite variable, ranging from total exclusion for even one headache occurrence to as
low as a 1-yr migraine-free period before consideration. In many instances, policy application has been subjective and not based on objective evidence. This presents a challenge to waiver authorities and also potentially sends a mixed message to command authorities. There is essentially no
current literature evidence applicable to the aviation population on migraine occurrence risk.METHODS: This study reviewed 71 U.S. Air Force pilot applicants who were diagnosed with migraine and had been granted waivers to assess any predictive factors for migraine recurrence and
its aeromedical impact.RESULTS: Only three applicants had recurrence after waiver was granted, with two of these occurring within 2 yr of their last reported migraine event, and all recurrences noted within 3 yr.DISCUSSION: Data indicated favorable risk with suitable
migraine-free observation before military pilot training, which could be incorporated into aeromedical standards and policies.Hesselbrock RR, Haynes JT. Migraine history and recurrence in military pilot applicants. Aerosp Med Hum Perform. 2020; 91(1):37–40.
Lead-Mining and the Lead Industry in Scotland, 1680–1780
Authors: Bassett Charlotte
Published: December 2019

Lead-mining was one of Scotland's few domestic industries during the seventeenth and eighteenth centuries. However, there is very little scholarly material available on this subject. T.C. Smout is one of the few historians who has written about the Scottish lead industry, but his articles were published in the 1960s and 70s. The aim of this article is address this gap in research by trying to establish the scale of mining activities, the industry's gross revenue, and its profit margins between 1680 and 1780. This paper relies heavily on archival records concerning Leadhills in Lanarkshire, which are primarily stored at Hopetoun House near South Queensferry. Leadhills was one of Scotland's two major lead mines and was acquired by the Hope family in the mid-seventeenth century. Mining activities at Leadhills quickly became the Hopes’ (who obtained the earldom of Hopetoun in 1703) primary source of income. The influence of the Hopes as lead barons became such that they built Hopetoun House, one of the country's most significant country houses, at the turn of the eighteenth century and aggrandised it for decades thereafter. This paper will confirm concretely the importance of Leadhills as a boon to the Hopes’ income and Scotland's increasingly globalised economy (particularly after the 1707 Union).
Bureaucratic Encounters and the Quest for Educational Access among Colombian Refugees in Ecuador
Authors: Rodríguez-Gómez Diana
Published: December 2019

Ecuador’s innovative approach to social policy and human mobility is reflected in its education policies, specifically those pertaining to access to school. Under Ecuador’s constitutional notion of universal citizenship, youth are not required to have previous academic records to enter the equivalent of K-12 education, regardless of their migratory status. Grade placement is based on a free test, and any identification documents a future student provides are officially deemed valid and sufficient for school registration. Despite these constitutional guarantees, refugee youth still have great difficulty enrolling in school in Ecuador. Drawing from semi-structured interviews with civil employees, NGO staffers, and Colombian refugees conducted in Quito, Ecuador, in 2013 and 2014, I analyze how access to school for Colombian refugee youth is shaped by the official and unofficial rules that regulate the formal education system. Situating policy as practice relative to the daily workings of the state bureaucracy, I analyze how public servants and refugees interpret and enact policy within the state’s administrative structure. I argue that, in this context, the appropriation of education policy and, therefore, access to education are mediated by the workings of bureaucracy. This implies that universal definitions of access to school obscure the contingent and unpredictable character of educational access for refugees. By delving into the manifold interpretations of education policy, this analysis suggests that an inconsistent bureaucracy has the potential to amplify social inequalities among refugees.
Nutrient content and in vitro digestibility of kermes oak (Quercus coccifera L.) growing in the provincial borders of Burdur
Authors: TÜREL Ali Osman , BUĞDAYCI Kadir Emre
Published: December 2019

The
purpose of this study was to investigate the in vitro dry
matter digestibility (IVDMD), nutrient content, cell wall components, total and
condensed tannin content of kermes oak (Quercus coccifera L.) which
is the main feed source for goat herds. Kermes oak was exemplified in 3
different stations during a year (12 months).  Sampling was made to
include leaves, some branches, acorns and young shoots, if any based on season,
which were consumed by the goats. The amount of dry matter (DM), crude ash
(CA), crude protein (CP), ether extract (EE), crude fibre (CF), acid detergent
fibre (ADF), neutral detergent fibre (NDF), acid detergent lignin (ADL), total
tannin and condensed tannin content, and IVDMD (by using two-stage technique)
were determined on the samples (12 × 3 = 36). Crude protein values were not
statistically significant in terms of seasonal averages. On the other hand, it
was found that the CF in spring and summer was significantly lower than the CF
in winter (P<0.05) and the highest EE during the year was in the autumn (P<0.05).
IVDMD of winter season was significantly lower than summer and autumn. (P<0.05). In
terms of total tannin content, it was revealed that autumn was significantly
lower than winter and spring (P<0.05). It was concluded that the nutritional
values and IVDMD of kermes oak were low in the winter season.
Makna Allah Pencipta Manusia dan Problematika Arti Kata ‘Kita’ di dalam Kejadian 1:26-27
Authors: Harefa Juliman
Published: December 2019

Artkel ini merupakan studi eksegetis kitab Kejadian 1:26-27, untuk memahami tentang siapa Allah pencipta, mengapa Allah menciptakan manusia yang disebut sebagai makhluk mulia dan mengkaji makna segambar dan serupa dengan Allah. Kajian ini menggunakan metode hermeneutik spiral (dari teks kepada konteks) yaitu studi eksegetis yang mengungkap makna teks asli Alkitab dan implementasi makna teks asli pada masa kini. Tugas eksegese adalah proses mendapatkan makna yang tepat dari bahasa Ibrani tentang topik tulisan, untuk itu dilakukanpekerjaan mencari maknaasli dari kata-kata kunci dalam bahasa Ibrani, sebagai bahasa asli yang digunakan dalam menulis kitab Kejadian. Berikutnya, memberikan makna teologis dari studi kata-kata bahasa Ibrani tersebut untuk diimplementasikan. Kajian teks kata Elohim, Yahwe/Adonay dan Kita mengandung arti kemahasucian, kemahakuasaan, keagungan dan kemuliaan Sang Pencipta alam semesta. Allah pencipta tersebut menciptakan manusia menurut gambar dan rupa-Nya, sehingga manusia memiliki “potensi ilahi” yang tidak dimiliki oleh makhluk lain yang diciptakan oleh Allah. Potensi ilahi adalah citra diri manusia yang memiliki jiwa akan dipahami sebagai kualitas sumberdaya manusia itu sendiri yakni potensi spiritualitas, rasio, kehendak yang akan diaplikasikan  dalam dunia sekuler, budaya dan pendidikan di era milenial.  Kata-kata kunci: Elohim, Allah, Hermeneutik, Kejadian, Eksegese
ESTRATEGIAS DE MERCADEO BASADAS EN EL MARKETING DIGITAL ORIENTADAS A LA CAPTACIÓN DE NUEVOS CLIENTES DE LAS PYMES. CASO DE ESTUDIO: GRUPO INTER GAME 2012, C.A.
Authors: Barón Sandra , Fermín Susana , Molina Enmari
Published: December 2019

El presente artículo muestra un plan estratégico de mercadeo, basado en el marketing digital orientado a impulsar la captación de nuevos clientes de lasPYMES, caso Grupo Inter Game 2012, C.A. Fue una investigación descriptiva con diseño de campo, realizándose el proceso de observación para la tomade la muestra y la aplicación de los instrumentos, los cuales estaban comprendidos por una entrevista estructurada y un cuestionario. Los datos recabados fueron analizados mediante índices estadísticos descriptivos individuales, mientras que para la entrevista se utilizó el análisis de contenido. La finalidad de la propuesta fue diseñar estrategias de marketing digital orientadas a la captación de nuevos clientes de Grupo Inter Game 2012, C.A. Se concluyó que la empresa desarrolla una labor satisfactoria para sus consumidores pero aún falta implementar estrategias que capten nuevos clientes y le permita no solo posicionarse en el mercado regional sino también nacional.
LA APLICACIÓN DE PAUSAS ACTIVAS COMO ESTRATEGIA PREVENTIVA DE LA FATIGA Y EL MAL DESEMPEÑO LABORAL POR CONDICIONES DISERGONÓMICAS EN ACTIVIDADES ADMINISTRATIVAS
Authors: Jaspe Carlos
Published: December 2019

Artículo que expresa los aspectos más resaltantes de analizar la aplicación de pausas activas como estrategia preventiva de la fatiga y el mal desempeño laboral por condiciones disergonómicas en actividades administrativas de una empresa manufacturera ubicada en el municipio Valencia, estado Carabobo, con el propósito de prevenir enfermedades ocupacionales, identificando condiciones disergonómicas y generar bienestar en los trabajadores en pro del desempeño laboral. Metodológicamente se trató de una investigación de campo descriptivo, se utilizó como técnicas de recolección de datos, la observación directa y laencuesta, en conjunto con los instrumentos: guía de observación y cuestionario los cuales fueron aplicados a una muestra de (21) trabajadores del área administrativa. Como resultado se recogió una alternativa para aumentar el desempeño laboral, disminuir dolencias físicas, estrés, desórdenes emocionales y riesgos laborales asociados a la actividad diaria.
A Neuro-Fuzzy System to Detect IPv6 Router Alert Option DoS Packets
Authors: Abdullah Shubair
Published: December 2019

Detecting the denial of service attacks that solely target the router is a maximum security imperative in deploying IPv6 networks. The state-of-the-art Denial of Service detection methods aim at leveraging the advantages of flow statistical features and machine learning techniques. However, the detection performance is highly affected by the quality of the feature selector and the reliability of datasets of IPv6 flow information. This paper proposes a new neuro-fuzzy inference system to tackle the problem of classifying the packets in IPv6 networks in crucial situation of small-supervised training dataset. The proposed system is capable of classifying the IPv6 router alert option packets into denial of service and normal by utilizing the neuro-fuzzy strengths to boost the classification accuracy. A mathematical analysis from the fuzzy sets theory perspective is provided to express performance benefit of the proposed system. An empirical performance test is conducted on comprehensive dataset of IPv6 packets produced in a supervised environment. The result shows that the proposed system overcomes robustly some state-of-the-art systems.
Posture de l’écrivain en sa bibliothèque ou la confrérie littéraire de Pierre Bergounioux
Authors: Ducas Sylvie
Published: December 2019

Cette étude s’intéresse aux filiations littéraires dans les essais de Pierre Bergounioux. On montrera que les plongées intertextuelles dessinent une confrérie littéraire et aident à construire un ethos d’écrivain dans les héritages et les lignages, sans que cette mise en scène auctoriale ne sacrifie à l’illusion de quelque grâce épiphanique du Grand Écrivain. Elle redonne plutôt au mot «auteur » toute sa charge sémantique : une autorité qui s’autorise à exister à mesure que l’écriture augmente le volume de l’oeuvre.
Abbâsi Sarayında Bir Mizâh Şairi: Ebû Dulâme
Authors: TOLAN Muhammet Bilal
Published: December 2019

ÖzArap mizâh geleneğinin önemli
temsilcilerinden biri olan Ebû Dulâme el-Esedî, Emevîlerin son dönemleri ile
Abbâsîlerin ilk üç halifesi olan Seffâh, Mansûr ve Mehdî dönemlerinde yaşamış
bir şairdir. Bu çalışmada şairin mizâh yeteneğinin ortaya çıkmasında etkili
olan hayat serüveni ve yaşadığı ortam resmedildikten sonra şairin sözlerindeki
ve şiirlerindeki mizâhi yön incelenmiştir. Abbâsîlerin ilk şairlerinden olması
hasebiyle Ebû Dulâme’nin bu dönemin şiir ve edebiyatının şekillenmesinde önemli
bir rolü vardır. Seffâh tarafından saraya alınması ile birlikte alaycı
kişiliği, latifeli sözleri, hikâyeleri ve nükteli şiirleriyle gerek halifeleri
ve gerekse diğer devlet ricalini eğlendirmeyi başarmıştır. Halifeleri güldürme
ve onlardan maddi fayda elde etme adına kendisini ve en yakınlarını alaya
almaktan çekinmemiştir. Eğlenceye fazlaca düşkün olduğundan dolayı dini
konularda hassas değildir. Anahtar Kelimeler: Arap edebiyatı, Ebû Dulâme, Şiir,
Mizâh, Abbâsîler. A Humorist in the
Abbasid Palace: Abû DulâmaAbstractAbû Dulâma al-Asadi, a prominent
representative of the Arabic humor tradition, is a poet who lived in the final
periods of the Umayyads and during the reigns of Saffâh, Mansûr and Mahdî, the
first three Abbâsid caliphs. This study depicted the poet’s life adventure and
where he lived which played a role in bringing out the sense of humor in him,
and analyzed the humor aspect in his words and poems. Being one of the first
poets of the Abbâsid era, he played a major role in shaping the poetry and
literature of the time. After being taken to the palace by Saffâh, he succeeded
in entertaining the caliphs and other statesmen alike with his sarcastic
personality, joking words, stories and witty poems. He did not hesitate to make
fun of himself and his closest relatives to make the caliphs laugh and obtain
material benefits from them. Since he was very fond of entertaining, he was not
sensitive about religious issues.

Keywords:
Arabic literature, Abû Dulâma, Poetry, Humor, Abbâsids.
Properties of the system of sources of law of the People's Republic of Lugansk
Authors: Sayenko Sergey I.
Published: December 2019

The article argues in favour of the fact that the totality of sources of law existing in the People’s Republic of Lugansk is a system of a socio-legal nature, formed as a result of the evolution of the state, and which reflects the ethnic, political, legal and other features of such an evolution. The system of sources of legal norms of the People's Republic of Lugansk has certain properties, among which one can distinguish – organisation, integrity, complexity, inertia and dynamism of such a system. The author of the article substantiates the provision that any proposals on the recognition of new species or on the exclusion of existing sources of law in the People's Republic of Lugansk should be considered through the prism of their (sources) of external and internal structural and functional relationships. The stability of the system of sources of law of the People's Republic of Lugansk should be the result of natural-historical, evolutionary processes. All attempts to radically accelerate the reorganisation of such a system are doomed to failure if the manifestations of the systemic properties of their sources are not taken into account.