bluuebunny/crossref_metadata_2025 huggingface dataset:
INSIGHTS INTO THE ROLE OF INJECTABLE PLATELET-RICH FIBRIN (I-PRF) IN TEMPOROMANDIBULAR JOINT (TMJ) DISORDERS: A COMPREHENSIVE REVIEW
Authors: M. Mala , A. Nandimath Santosh , G.C Rajkumar
Published: August 2024

Background: Temporomandibular joint (TMJ) disorders are a diverse group of conditions that affect the joint and associated muscles, leading to significant pain, functional limitations, and reduced quality of life. Traditional treatments, such as non-steroidal anti-inflammatory drugs (NSAIDs), physical therapy, and surgical interventions, often provide limited relief and are not always well-tolerated. Objective: This review aims to evaluate the current evidence on the efficacy of injectable platelet-rich fibrin (i-PRF) as a treatment for TMJ disorders, exploring its potential as a less invasive alternative to conventional therapies. Methods: A comprehensive search of the literature was conducted, focusing on recent studies and systematic reviews that investigate the use of i-PRF for TMJ disorders. Key databases were searched for relevant articles, and studies were selected based on their relevance and methodological quality. Results: Recent research indicates that i-PRF, a modern platelet concentrate derived from the patients own blood, may offer substantial benefits for treating TMJ disorders such as osteoarthritis, disc displacement, and dysfunction. Evidence suggests that i-PRF could significantly reduce pain and improve functional outcomes. The regenerative properties of platelets and growth factors in i-PRF contribute to enhanced tissue healing and reduced inflammation, potentially offering a viable alternative to traditional treatments. Conclusion:i-PRF appears to be a promising, less invasive option for managing TMJ disorders, with potential advantages over conventional therapies. However, further studies are needed to confirm its effectiveness, optimize treatment protocols, and address any limitations in the current research. This review consolidates recent findings and assesses the potential of i-PRF to advance the field of joint therapy.
RARE HEMATOLOGICAL COMPLICATION OF HEPATITIS A IN CHILDREN:BONE MARROWAPLASIA IN A CASE REPORT
Authors: El Houda Benchaib Nour , Ghanam Ayad , El Ouali Aziza , Babakhouya Abdeladim , Rkain Maria
Published: August 2024

Introduction: Complicated forms of hepatitis A, particularly hematological complications, are rare and are described as severe conditions in children. Case Report: This case involves a 4-year-and-4-month-old girl who initially presented with a cholestatic jaundice flare due to viral hepatitis A. The symptomatology became complicated a month later by a hemorrhagic syndrome consisting of recurrent epistaxis, pallor, and asthenia, evolving in a context of prolonged fever and deterioration of the general condition. Clinical examination found a febrile child at 39Â°C, generalized cutaneous-mucosal pallor, petechial purpuric spots on the trunk, and no hepatosplenomegaly. The hematological workup showed aregenerative pancytopenia with normal transaminases. The myelogram revealed a poor bone marrow. Bone marrow biopsy confirmed bone marrow aplasia. Vitamin B12 and B9 levels were normal. Serologies for HBV, HCV, EBV, and CMV were negative. HVA IgG serology was positive with borderline HVA IgM. The patient was put on transfusion support with third- generation cephalosporin and aminoglycoside antibiotics. The diagnosis of post-hepatitis acquired bone marrow aplasia was confirmed. Treatment with cyclosporine was started, leading to good clinical evolution and improvement of the hemogram after two months of follow-up. Conclusion: Although hematological complications of hepatitis A are still rare, they remain fatal in the majority of cases. This underscores the need for biological and clinical monitoring in the management of hepatitis A in children.
PSYCHOLOGICAL SAFETY IN HIGH-PERFORMANCE TEAMS
Authors: Mehrotra Ravi
Published: August 2024

One of the major ingredients that perhaps differentiates high-performing teams from others is psychological safety, which confers members of the team with the courage to express themselves without the fear of being received adversely. This paper will discuss the role of psychological safety in a high-performance team: how it impacts the functioning and performance of the team, and ways of building such an environment. Through the literature review and case examples, it is hoped that the research will be able to reveal how psychological safety can enable better teamwork, innovation, and overall team effectiveness.
RAPID REHABILITATION ARTHROPLASTY PROTOCOL IN SAUDI ARABIA : REDUCING HOSPITAL STAY
Authors:   Department of Trauma and Orthopaedic Surgery, Armed Forces Hospital Southern Region, Khamis Mushait, Saudi Arabia., Alshehri Turki , Maqbool Ali ,   Medical Student Agha Khan University Hospital Karachi Pakistan., Ali Altheeb Saeed ,   Department of Trauma and Orthopaedic Surgery, Armed Forces Hospital Southern Region, Khamis Mushait, Saudi Arabia., Atiah Qaysi Abdulaziz ,   Department of Trauma and Orthopaedic Surgery, Armed Forces Hospital Southern Region, Khamis Mushait, Saudi Arabia., Maqbool M. ,   Senior Consulatant Arthroplasty, Department or Trauma And Orthopaedic Surgery, Khamis Mushait, Saudi Arabia.
Published: August 2024

Background: Fewstudies havefocused on patient characteristics that influence lengthof stay in fast-track total hip (THR) and kneearthroplasty (TKR). The aim of this retrospective studywas to identify patient characteristics associated withlength of stay and patient satisfaction after total hip and kneereplacement surgery. Patients and Methods: Between January 2023 toJune 2023,62 TKR patientswith a mean age of 67.6Â±11.8years and 12 THR with a mean age of 53.8Â±17.0wereadmitted at ourspecialized fast-track joint replacement unit. A single fellowship-trained surgeon operated on all patients.We did interviews with the patients before the operation and 6 weeks after surgery to collect pre and post-operative Oxford knee scores for TKRs and pre and post-operation Oxford hip scores for THRs. Results: A total of 62 TKR patients and 12 THR patients enrolled in our study. The mean age of TKR patients was 67.6Â±11.8years, and 44 subjects (71%) were female. The mean age of THR patients was 53.8 yearsÂ±17.0, and 8 subjects (66.7%) were male. Mean of BMI was reported as 33.9Â±6.1 in TKR patients and 30.9Â±6.1 in THR patients. The Mean of ASA was 2.2Â±0.6 in TKR patients and 1.9Â±0.5 in THR patients. Length of stay in hospital was documented as 3.9Â±0.7 in TKR patients and 4.3Â±0.6 in THR patients.Most patients of have osteoarthritis, while rheumatoid arthritis was reported in TKR (n=3, 4.8%) and THR (n=1, 8.3%) patients. A significant length of stay was reported with increasing BMI and ASA score in TKR and THR patients. In Conclusion: The most common diagnosis for surgery was osteoarthritis, which usually affected womens right sides. Annual increases in the number of surgeries have been made, and Oxford ratings indicate that they have a very high success rate. The characteristics linked with a prolonged duration of stay after total hip or knee arthroplasty are significantly influenced by the case mix, particularly the BMI and ASA before surgery.
A STUDY TO ASSESS THE LEVEL OF TIME MANAGEMENT ON DAILY ROUTINE AMONG NURSING OFFICERS IN SMVMCH AT PUDUCHERRY
Authors:   M. Sc (Nursing)-II Year, Sri Manakula Vinayagar Nursing College., G. Sujitha , A. Ayee ,   Reader in Nursing, Sri Manakula Vinayagar Nursing College., G. Muthamilselvi ,   Principal, Sri Manakula Vinayagar Nursing College.
Published: August 2024

Time management is the process of organizing and using time so that an individual can work as efficiently as possible and produce a highly productive result. A study to assess the level of time management on daily routine among nursing officers in SMVMCH at Puducherry.A descriptive research design was selected for this study to assess the level of time management on daily routine by using time management personal assessmentamong nursing officers in SMVMCH, Puducherry. Purposive sampling technique were used for this present study. The total number of 100 Nursing officer were selected for this study. The collected data was analyzed by using descriptive and inferential statistics.In level of time management on daily routine, majority 67% of them belongs to Fairly time management skill and 20 % belongs to Time management skill should be improved, 13 % belongs to Excellent time management skill. There is a significant association between the age group, gender, religion, residence and designation, duration of service in SMVMCH at the level of p<0.05. Whereas the other demographic variables have no significance at the level of p<0.05. It is concluded that the time management among nursing officers were found to be level and it need to have an attention at the earliest to manage their time management in excellent way, on the later days.
TRANSNATIONAL ORGANISED CRIMES WITH SPECIAL REFERENCE TO MARINE PIRACY
Authors:   Assistant Professor, Government Law College, Thrissur, Kerala., Jyothi Joseph Mary
Published: August 2024

Piracy has been a pervasive issue for centuries. Historically, it gained momentum during the era of slave trade, with pirates plundering cargoes from merchant vessels in the open sea, resulting in the loss of life and property, as well as economic damage. As maritime trade expanded, it became necessary to establish laws to curb and counter piracy, which posed a significant threat. International conventions were subsequently developed to safeguard stakeholders, but their limited effectiveness was due to the non-binding nature of these agreements. Weaknesses in domestic laws, lack of jurisdiction, and inadequate trial procedures further hindered the efforts of individual states to combat piracy, leading to collaborative initiatives and naval operations to confront the perpetrators at sea. The article aims to explore the measures that have been implemented to tackle piracy in the maritime domain. The author has provided a brief overview of the topic, focusing on transnational organised crime against humanity. It is recommended that readers delve deeper into the subject to gain a comprehensive understanding of the issue.
Experimental study on interceptor performance of bridge rainwater inlet
Authors: Wan Lijun , Zhang Zixuan , Wang Lijun , Zhao Tianrong , Geng Yuanming , Zhao Mai , Sun Xianglong
Published: August 2024

Rainwater inlets are important for bridge drainage, and this paper carries out modeling tests on the interception performance of bridge rainwater inlets in the Daxinganling region of China. The effects of slope, different inlet methods, and grate opening forms on the interception efficiency of rainwater inlets are mainly investigated. The results show: (1) Rainwater inlet interception efficiency increases with increasing cross slope and decreases with increasing longitudinal slope. (2) The innovatively proposed inlet method of spraying above the flume, which is less efficient than the rainwater inlet interception of the diffuse flow method at the front of the flume, the inlet method is more in line with the actual situation. (3) Combined with the weir flow formula to fit the interception efficiency formula, the relative error between the predicted and measured values of the interception efficiency of the formula is less than 5%, indicating the applicability of the formula. (4) Comparing the interception efficiency of grates with different opening forms, it is concluded that the longitudinal curved opening is the best, followed by the longitudinal linear opening, and the transverse opening is the worst. In the transverse opening grates, the fewer longitudinal bars, the better the interception efficiency.
An innovative method to remove phenols from olive mill wastewater using heterogeneous modified polyacrylonitrile (PAN) catalyst
Authors: Milnes Hannah , Huddersman Katherine , Matouq Mohammed , Tiwary Abhishek , Alayed Omar , Kloub Nasir
Published: August 2024

Phenolic compounds contained in olive oil mill wastewater (OMW) cause environmental issues when left untreated. A novel heterogeneous surface functionalised nanocoated polyacrylonitrile (PAN) mesh used as a Fentons' catalyst acting with hydrogen peroxide gave 70–100% phenol reduction and an average total organic carbon (TOC) reduction of 64.7% when seven phenols as described below were individually treated (100 mg/L phenolic, 500 mg/L H2O2, 12 g catalyst, 20 °C). As a mixture of seven phenols (100 mg/L of each, 12 g catalyst, 3,500 mg/L H2O2), such as trans-cinnamic acid, p-coumaric acid, caffeic acid, vanillic acid, ferulic acid, tyrosol and hydroxytyrosol, there was 77.5% phenol and 43.9% TOC reduction. The addition of UVc light (100 mg/L phenolic, 500 mg/L H2O2, 12 g catalyst, 20 °C, UV flux 2.66 mW/cm2) significantly improved the degradation of the initial phenolic concentration by 98% in the individual treatments. A pH of 3 and a temperature of 30 °C were found to be the most effective and efficient. The fresh and regenerated catalysts were both recycled over 10 cycles before deactivation which shows promise for continuous flow and scale-up for use as an OMW treatment.
Blockage dynamics in sewer pipes: investigating snagging, accumulation, and dissipation rates of wet wipes
Authors: Kargar Katayoun , Joksimovic Darko
Published: August 2024

The increase in sewer blockages, exacerbated by the COVID-19 pandemic due to improper disposal of non-biodegradable items like wet wipes and sanitary products, along with fats, oils, grease, and the presence of defects in sewers, underscores the need for a more profound understanding of wipes’ contribution to these blockages. This study investigated the probability of wipe snagging on sewer imperfections and their subsequent accumulation and dissipation rates under various conditions through laboratory experiments. Findings indicated a significant variability in the likelihood of wipes snagging (ranging from 93% to 0) and accumulating (ranging from 71% to 0), which was influenced by the defect location and the sewer flow rate. Moreover, the study highlighted a direct relationship between the flow rate in the sewer and the rate at which wipes dissipate. Conversely, an inverse relationship was observed between the size of blockages and the dissipation rate of wipes, with larger blockages typically reducing the speed of this process. Importantly, while dissipation rates at low flow rates are nearly constant regardless of the number of wipes and duration, at medium to high flow rates, dissipation initially increases but levels off after 24 h, demonstrating the persistence of wipe-caused blockages in small-diameter sewer pipes.
Cumplimiento de la Resolución 2350 de 2020 en las Direcciones locales de salud, Córdoba, Colombia
Authors: Cadavid-Velásquez Lurky Esther , Amador-Ahumada Concepción Elena , Ripoll-García Luz Dary
Published: August 2024

Introducción: el cumplimiento de los lineamientos de intervención en desnutrición aguda por las Direcciones Locales de Salud debe garantizar procesos de atención integral. Sin embargo, estas se encuentran serias insuficiencias reflejadas en la atención integral. Objetivo: evaluar el cumplimiento de la guía de atención integral de la desnutrición aguda en niños menores de cinco años en los municipios de Córdoba. Método: estudio descriptivo en el que participaron Direcciones Locales de Salud de municipios del Departamento de Córdoba. Mediante entrevistas, observación y auditoría de evidencias se tomó información para evaluar el porcentaje de cumplimiento de los reactivos de la Resolución Resultados: el nivel de cumplimiento global es medio-bajo (69%). Una amplia franja de los reactivos (87,5%) del evento código 113, se encuentran con grados de cumplimiento de moderados a bajos incluido el control y seguimiento de los casos identificados. Conclusiones: el cumplimiento de los lineamientos establecidos en la Resolución es deficiente.
Vitamin B12 deficiency and depressive symptoms: A narrative review of the literature
Authors: Barliza-Quintana Feligno Alberto , Pachón Cindy Alejandra
Published: August 2024

Depression has a complex origin that involves genetic, neurophysiological, hormonal, psychosocial, and environmental factors. There is a possible relationship between vitamin B12 deficiency and depression, with evidence that supplementation may alleviate symptoms in adults treated with selective serotonin reuptake inhibitors. Although this association has been found, a direct causal relationship has yet to be established, which requires more rigorous research. This article reviews and synthesizes the available evidence on this relationship and its clinical implications. More studies are needed to confirm the association and detection in at-risk populations.
Calidad de la información odontológica en historias clínicas para fines forenses
Authors: Barraza-Salcedo María del Socorro , Herrera-Herrera Alejandra del Carmen
Published: August 2024

Introducción: la calidad de las historias clínicas odontológicas es importante para fines clínicos y forenses. Sin embargo, se conoce poco de la calidad estas historias para estos fines en el contexto colombiano. Objetivo: evaluar la calidad de la información odontológica de las historias clínicas para fines forenses. Método: se diseñó un estudio descriptivo en el que se analizaron historias clínicas realizadas durante el 2022. Resultados: se revisaron 120 historias clínicas, en 72% se evidenció un correcto diligenciamiento del odontograma, 88% era legibles, 75,4% estaban actualizados los tratamientos, 56% fueron llenadas “satisfactoriamente”, 44% presentaron tachones y enmendaduras, 8% estaba con simbología dental actualizada para tratamiento y 92% presentaba inconsistencias. Conclusiones: es limitada la calidad de las historias odontológicas para fines forenses. Se necesitan estudios analíticos que estudien los factores asociados a la calidad de las historias odontológicas con fines forenses.
Trastornos de comportamiento alimentario: un problema olvidado en el Departamento del Magdalena, Colombia
Authors: Campo-Arias Adalberto , Piraneque-Aguirre Laura Sofía , Parra-Castilla Daniela Carolina
Published: August 2024

Eating disorders (ED) are characterized by significant distortion of body image associated with behavioral changes related to food intake and weight control.
Calidad microbiológica de la leche cruda de bovinos de Paipa, Colombia
Authors: Mosso-Arias John Marco Andrés , Alfonso-Vargas Nadia Catalina , Aguilera-Becerra Astrid
Published: August 2024

Introducción: las enfermedades transmitidas por alimentos constituyen una de las mayores problemáticas públicas a nivel mundial. Actualmente hay nulo conocimiento sobre la calidad microbiológica de la leche cruda de bovinos en Paipa y sectores aledaños. Objetivo: determinar la calidad microbiológica de la leche cruda de ganado bovino de una finca del municipio de Paipa, Boyacá. Método: se diseñó un estudio descriptivo en el que se recolectaron muestras de leche cruda de ganado bovino para ser analizadas microbiológicamente y realizar el recuento de aerobios mesófilos, Staphylococcus aureus coagulasa positivos, Coliformes totales y fecales, mohos y levaduras, así como la presencia/ausencia de bacterias patógenas como Listeria sp. y Salmonella sp. Resultados: se analizaron 25 muestras de leche cruda y se evidenció que la mayoría de las muestras incumplen con el límite permisible que dicta la norma. La prevalencia de Salmonella sp. del 24% y de Listeria sp. fue del 0%. Conclusiones: las muestras de leche cruda analizadas incumplen con los límites permisibles en las normas que rigen para Colombia. Se recomienda realizar más estudios para conocer la realidad microbiológica de la leche en el sector.
Prediction of Prognosis and Immunotherapy Response of Gastric Cancer Based on Glutamine Metabolism-Related Genes
Authors: Gong Saisai , Yang Sheng , Zhang Tianyi , Li Jie , Wan Xin , Fang Yifei , Liu Tong , Li Chengyun , Zhou Yun , Liang Geyu
Published: August 2024

Background:

Reprogramming of glutamine metabolism in Gastric Cancer
(GC) can significantly affect the tumor immune microenvironment and immunotherapy.
This study examines the role of glutamine metabolism in the microenvironment and
prognosis of gastric cancer.

Methods:

We obtained gene expression data and clinical information of patients from
the TCGA database. The patients were divided into two metabolic subtypes based on
consistent clustering. A prognostic risk model containing three glutamine metabolism-related
genes (GMRGs) was developed using Lasso-Cox. It was validated by the GEO
validation cohort. Additionally, the immune microenvironment composition of the highand
low-risk groups was assessed using ESTIMATE, CIBERSORT, and ssGSEA. Drug
sensitivity analysis was conducted using the “oncoPredict” R package.

Results:

We outlined the distinct clinical characteristics of two subtypes and developed
a prognostic risk model. The high-risk group has a poorer prognosis due to an increased
expression of immune checkpoints and immunosuppressive cellular infiltration. Our
analysis, which included Cox risk regression, ROC curves, and nomogram, demonstrated
that this risk model is an independent prognostic factor. The TIDE score was higher
in the high-risk group than in the low-risk group. Additionally, the high-risk group did
not respond well to chemotherapeutic drug treatment.

Conclusion:

This study shows that modelling glutamine metabolism is a good predictor
of prognosis and immunotherapy efficacy in gastric cancer. Thus, we can better understand
the role of glutamine metabolism in the development of cancer and use these insights
to develop more targeted and effective treatments.

result:

We have outlined the distinct clinical characteristics of two subtypes and developed a prognostic risk model. The high-risk group has a poorer prognosis due to an in-creased expression of immune checkpoints and immunosuppressive cellular infiltra-tio. Our analysis, which includes Cox risk regression, ROC curves, and nomogram, has shown that this risk model is an independent prognostic factor. The TIDE score was higher in the high risk group than in the low risk group. Additionally, the high-risk group did not respond as well to chemotherapeutic drug treatment.
Exploration of Pharmacological Mechanism of Cinnamomum tamala Essential Oil in Treating Inflammation based on Network Pharmacology, Molecular Modelling, and Experimental Validation
Authors: Mohanty Debajani , Padhee Sucheesmita , Jena Sudipta , Sahoo Ambika , Panda Pratap Chandra , Nayak Sanghamitra , Ray Asit
Published: August 2024

Background:

Cinnamomum tamala (Buch.-Ham.) T.Nees & Eberm., also known as Indian bay leaf,
holds a distinctive position in complementary and alternative medicinal systems due to its anti-inflammatory
properties. However, the active constituents and key molecular targets by which C. tamala essential oil (CTEO)
exerts its anti-inflammatory action remain unclear.

Objective:

The present study used network pharmacology and experimental validation to investigate the mechanism
of CTEO in the treatment of inflammation.

Methods:

GC-MS analysis was used to identify the constituents of CTEO. The key constituents and core targets
of CTEO against inflammation were obtained by network pharmacology. The binding mechanism between
the active compounds and inflammatory genes was ascertained by molecular docking and molecular dynamics
simulation analysis. The pharmacological mechanism predicted by network pharmacology was verified
in lipopolysaccharide-stimulated murine macrophage (RAW 264.7) cell lines.

Results:

Forty-nine constituents were identified by GC-MS analysis, with 44 constituents being drug-like candidates.
A total of 549 compounds and 213 inflammation-related genes were obtained, revealing 68 overlapping
genes between them. Compound target network analysis revealed cinnamaldehyde as the core bioactive
compound with the highest degree score. PPI network analysis demonstrated Il-1β, TNF-α, IL8, IL6 and TLR4
as key hub anti-inflammatory targets. KEGG enrichment analysis revealed a Toll-like receptor signalling pathway
as the principally regulated pathway associated with inflammation. A molecular docking study showed
that cinnamaldehyde strongly interacted with the Il-1β, TNF-α and TLR-4 proteins. Molecular dynamics simulations
and MMPBSA analysis revealed that these complexes are stable without much deviation and have better
free energy values. In cellular experiments, CTEO showed no cytotoxic effects on RAW 264.7 murine
macrophages. The cells treated with LPS exhibited significant reductions in NO, PGE2, IL-6, TNF-α, and
IL-1β levels following treatment with CTEO. Additionally, CTEO treatment reduced the ROS levels and increased
the antioxidant enzymes such as SOD, GSH, GPx and CAT. Immunofluorescence analysis revealed
that CTEO inhibited LPS-stimulated NF-κB nuclear translocation. The mRNA expression of TLR4, MyD88
and TRAF6 in the CTEO group decreased significantly compared to the LPS-treated group.

Conclusion:

The current findings suggest that CTEO attenuates inflammation by regulating TLR4/MyD88/NF-
κB signalling pathway.
A Review on the Mechanisms, Applications, and Clinical Trials of Advanced Technologies in the Transdermal Drug Delivery System
Authors: Abdul Aziz Afina Faqkira , Beh Yun Qing , Farahiyah Iffah Izzati , Syahrul Azmir Soraya , Kee Phei Er , Helal Uddin A. B. M. , Liew Kai Bin
Published: August 2024

Transdermal Drug Delivery Systems (TDDS) have emerged as a promising method
for administering therapeutic agents due to their non-invasive nature and patient-friendly approach.
However, the effectiveness of this system is limited to drugs with specific physicochemical
properties that allow for transdermal delivery as the skin acts as a barrier. To address this
limitation, researchers have been exploring alternative approaches to improve drug delivery
through the stratum corneum, ensuring consistent drug distribution at controlled rates. Thirdgeneration
delivery systems have been developed to facilitate the delivery of various drugs
across the skin barrier by disrupting the stratum corneum while protecting deeper skin tissues
from injury. This review has explored various approaches that have gained popularity in enhancing
drug delivery through TDDS, including microneedle-mediated, nanoparticle-enabled, thermal
ablation-enhanced, and electroporation-driven delivery systems. It has discussed the mechanisms
of drug delivery and potential applications for different types of drugs and detailed the
clinical studies. This review has also highlighted the significant advancements in TDDS, offering
valuable insights into both the pharmaceutical field and biomedical applications. The continued
exploration and refinement of these delivery systems, particularly with the incorporation
of Internet-of-Things (IoT) technology, Artificial Intelligence (AI), and machine learning, hold
promise for expanding the scope of therapeutic interventions.
Nanocrystals: Versatile Platform for Traditional Chinese Medicine Delivery
Authors: Ren Chuanyu , Gao Yue , Huang Yeqi , Peng Siyuan , Zhang Xuan , Wang Weijie , Wu Chuanbin , Pan Xin , Huang Zhengwei
Published: August 2024

The medicinal value of Chinese medicines has been recognized since ancient times,
and they have also been used to treat various diseases. However, in-depth studies on the active ingredients
of Chinese medicines have shown that many of them suffer from poor water-solubility,
stability, and bioavailability, which has severely limited their further development. The advent of
nanomedicine represents a novel direction and paradigm for addressing these challenges. Particularly,
within the framework of nanocrystal technology, enhancements in the water solubility, stability,
and bioavailability of Chinese medicines are expected to significantly improve the therapeutic
efficiency. This advancement also holds promise for unlocking new therapeutic capabilities.
Nanocrystals offer significant advantages in oral, intravenous, intranasal and targeted delivery.
The drug loading principle is “all in one”, with hydrophobic-drug-in and hydrophilic-drug-out and
stabilization by amphiphilic agents. Nanocrystal technology in traditional Chinese medicine
(TCM) holds extensive application potential. Continuous refinement of preparation techniques,
sound safety assessments, and the promotion of large-scale production are anticipated to augment
its pivotal role in TCM formulations, thereby creating novel opportunities for clinical drug therapy.
Identification of Two HIV-1 CRF01_AE/B Recombinant Forms and a CRF01_AE/B/C Recombinant Form in Hebei Province, China
Authors: Tang Xiangyun , Liu Meng , An Ning , Zhang Xinyu , Wang Yingying , Li Yan , Lu Xinli
Published: August 2024

Background:

In the Hebei province, Human Immunodeficiency Virus type one
(HIV-1) recombinant strains of subtypes B, C, and CRF01_AE are emerging very rapidly and diversely.

Objective:

In order to confirm the characteristics of novel recombination forms, we aimed to analyze
HIV-1 Near-full-length Genome sequences (NFLGs) obtained from three Men who have Sex
with Men (MSM) in this study.

Methods:

Phylogenetic trees were constructed and breakpoints analysis was performed based on
the NFLGs and each gene fragment to examine the gene recombination patterns of three new
HIV-1 NFLGs.

Results:

HIV-1 subtypes CRF01_AE and B were combined to generate the recombinant structures
of the NFLGs 610 and 687. CRF01_AE, B, and C were combined to generate the recombinant
structures of the NFLG 825. According to the NFLG phylogenetic tree, the NFLG 825 clustered
with CRF65_cpx and the NFLGs 610 and 687 clustered with CRF68_01B. The recombination
breakpoints analysis revealed that the recombination pattern of the NFLGs 610 and 687 was the
insertion of subtype B fragment into the CRF01_AE backbone. Subregions I, II, and III were derived
from CRF01_AE, subtype B, and CRF01_AE, respectively. The recombination pattern of
the NFLG 825 contained ten fragments of subtypes CRF01_AE, C, and B. Finally, the above factors
were formed using phylogenetic trees and breakpoints analysis, which were combined to get
two CRF68_01B forms and one CRF65_cpx form.

Conclusion:

Our findings have suggested that it is crucial to keep an eye on the genetic diversity
of HIV-1 in Hebei province.
Exploring Potential Bioactive Components of Persea americana for the Treatment of Rheumatoid Arthritis through Network Pharmacology
Authors: Akey Krishna Swaroop , M Esakkimuthukumar , R Saranya , M Chandru , S Sowbarnika , J Sudharsan , V Dhanush , Prabha Thangavelu , S Jubie
Published: August 2024

Introduction:

Rheumatoid arthritis (RA) is a chronic autoimmune disease character-ized by inflammation and joint destruction, leading to significant disability and reduced quality of life. Current treatment options for RA have limitations, highlighting the need for novel therapeu-tic approaches. In this study, we employed network pharmacology methods to identify potential bioactive compounds from Persea Americana (avocado) for the treatment of RA.

Materials and Methods:

We collected information on the phytoconstituents of avocados from the IMPPAT database and used Data Warrior software to filter out 64 plant constituents based on ADMET criteria. Target genes associated with avocado compounds were identified using the Bindingdb web server, resulting in 209 genes from Persea Americana. Protein-protein interaction (PPI) network analysis was performed using Cytoscape software to identify key genes and pro-teins involved in RA. Protein-drug interactions were analyzed, and ten avocado constituents with high binding affinity were identified.

Results and Discussion:

Our network pharmacology analysis revealed that avocado constituents, particularly Luteolin, have the potential to be developed as novel therapeutics for RA. The PPI network analysis identified key genes and proteins associated with RA, providing insights into the molecular mechanisms of the disease. The high binding affinity observed between Luteolin and PTGS2, a protein involved in joint inflammation, suggests its potential effectiveness in mitigating RA-related inflammation.

Conclusion:

Our study highlights the potential of avocado constituents, particularly Luteolin, as promising therapeutics for the treatment of rheumatoid arthritis (RA). Through network pharma-cology analysis, we identified key target genes and proteins associated with RA, shedding light on the underlying molecular mechanisms of the disease.
Determinants of Health-related Quality of Life in Breast Cancer Patients: A Comprehensive Study in Marrakech, Morocco
Authors: Belhaj Haddou Meryam , Igarramen Tariq , Khouchani Mouna , Elkhoudri Noureddine
Published: August 2024

Introduction

The assessment of quality of life (QoL) has become crucial for evaluating treatment effectiveness and prognosis in oncology, especially in the case of breast cancer, where patients are at a high risk of experiencing reduced QoL during active treatment. The objective of this study is to assess health-related quality of life and examine the socio-economic and clinical factors influencing it in breast cancer patients in the city of Marrakech, Morocco.

Methods

The study was conducted on 220 breast cancer patients at the Marrakech University Hospital in Morocco. Quality of life was evaluated using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and the specific Breast Cancer questionnaire (EORTC-QLQ-BR23). Descriptive statistics, correlation analysis between socio-economic and clinical factors with QoL subscales, and linear regression were performed to analyze the data.

Results

The results indicated that the mean score for overall health was 60.4%. Social functioning had the highest score (85.8%), while emotional functioning had the lowest (70.4%). Among the symptom scales, the most concerning were fatigue, loss of appetite, pain, and financial difficulties. For QLQ-BR-23, the future perspective was the most affected domain (25.30%), as well as body image (13.79%). Symptom scale scores ranged from 20.4% to 61.6%, with the most concerning symptom being systemic treatment of side effects. The results showed that age (p= 0.011, β= -0.142), disease duration (p = 0.000, β= 0.624), and monthly income (p = 0.000, Β= 0.233) significantly influenced quality of life. Body image was significantly associated with marital status (p= 0.049, β= -0.140) and type of surgery (p = 0.031, β= -0.149). Sexual pleasure was correlated with marital status (p = 0.037, β= 0.191) and radiotherapy treatment (p = 0.021, β= -0.223).

Conclusion

The study revealed that patients have concerns related to financial difficulties while coping with symptoms associated with their illness. Age, disease duration, and monthly income were found to be the factors influencing the quality of life. Furthermore, body image was affected, as was emotional well-being, emphasizing the importance of addressing psychological aspects in their care by healthcare professionals.
Inhibition of Subsequent Commutation Failures in Ultra-High Voltage Direct Current Transmission Systems Using Electrochemical Energy Storage at the Sending End
Authors: Wang Wenhui , Xu Yefei
Published: August 2024

Introduction:

Subsequent commutation failures (SCFs) in high-voltage direct
current (HVDC) systems pose a serious threat to the safe operation of hybrid AC/DC grids.
Electrochemical energy storage, which is widely distributed at the sending end of ultrahigh
voltage direct current (UHVDC) transmission systems, has the potential to mitigate
SCFs. To fully harness the SCF-mitigating capabilities of energy storage, this article first
establishes a CIGRE-HVDC standard test model incorporating electrochemical energy
storage at the sending end.

Method:

Based on this model, the factors influencing DC commutation failures are investigated.
Furthermore, the impact of rectifier-side electrochemical energy storage (EES) on
inverter-side commutation failures is explored from three aspects: energy storage capacity,
output magnitude, and fault conditions. It is found that rectifier-side EES absorbing power
can effectively suppress inverter-side commutation failures. Finally, based on this finding,
a transient active power control strategy for energy storage is designed to inhibit consecutive
commutation failures and is studied on the CIGRE-HVDC standard test system. It is
concluded that the optimal capacity for suppressing SCFs is between 20% and 30% of the
DC capacity, and the best absorption power output is achieved with a per-unit value of 1.

Result:

Simulation results confirm the correctness of the proposed energy storage transient
active power control strategy and its effectiveness in suppressing SCF under different fault
moments, fault severities, and fault types.

Conclusion:

This strategy can limit the number of SCFs to three or fewer in the majority
of operating conditions, facilitating rapid system recovery after faults.
Preoperative Concerns of Older Patients Undergoing Non-cardiac Surgery: A Systematic Review and Meta-analysis
Authors: Qu Marianna , Liu Winnie , Yan Ellene , Saripella Aparna , Englesakis Marina , He David , Chung Frances
Published: August 2024

Background

Older adults (≥ 50 years) possess unique preoperative concerns influenced by age-related needs, perceptions, and health status. When left unaddressed, these concerns are risk factors for postoperative morbidity and mortality. Despite the aging demographic, these concerns in older patients have not been systematically examined. This systematic review and meta-analysis aims to summarize the preoperative concerns of older patients.

Methods

Five databases were searched from January 1, 2000 to March 26, 2023. Studies with 1) patients ≥ 50 years undergoing non-cardiac surgery; 2) concerns identified preoperatively with validated instruments; 3) at least one preoperative concern reported (mean, degree or incidence of concern); 4) randomized controlled trials, prospective cohort, or cross-sectional studies were included. Concerns were classified into domains and subdomains. Meta-analysis was performed when two or more studies assessed concerns utilizing the same instrument.

Results

Seventeen studies with 1,777 patients were included. The mean age was 68.3 ± 9.9 years, with 51.4% female. Surgeries were classified as mixed, orthopedic (elective or emergent), and high-burden (abdominal, vascular, oncological). Concerns were categorized into domains: 1) anesthesia, 2) surgery, 3) pain, 4) complications, 5) medical experience, 6) recovery and rehabilitation, and 7) impact on daily life. Patients reported a greater degree of anxiety relating to surgery than anesthesia: 1.54 (95% CI: 1.12-1.95, P<0.00001). The top three concerns across all surgeries (mixed, orthopedic, and high-burden) were complications, pain, and rehabilitation/recovery. Pain and complications were the greatest concerns in elective orthopedic procedures and emergent procedures, respectively. In high-burden surgeries, patients were primarily concerned about complications.

Conclusion

Surgery-related concerns were 50% greater than anesthesia-related concerns. The three main concerns in older patients were complications, pain, and rehabilitation/recovery. The top concerns varied among specific surgical types. These findings emphasize the importance of tailoring preoperative counseling to address specific fears of each surgical population.
Market Scenario of Medicinal Plants: Understanding the Condition during COVID-19
Authors: Bose Bibin , Kumar S. Siva
Published: August 2024

Introduction:

A major share of medicinal plants in India is collected from tropical forests.
These plants are widely used to treat various infectious diseases, particularly during the recent pandemic.
Governments have recommended different medicinal plants for treating the symptoms and
management of COVID-19 in the country, where these plants have been used to treat different ailments
for centuries. The recent pandemic has led to increased dependency on Traditional, Complementary,
and Integrative Medicine, especially for post-care treatment and symptom management,
which has led to an increase in demand for these plants, but there is a limited understanding of the
availability of these plants, especially those which are used for treatment. Hence, this study aimed to
analyze the market scenario of medicinal plants.

Methods:

This research was conducted through secondary data analysis, using data collected from
government reports and the collected data was analysed using percentage analysis.

Results:

his study found there is a low and steady increase in the export of medicinal plants and a
demand of 511510 MT of produce, among which Amla, Aswaghanga, Kalmegh and Mulethi have
higher demand among the medicinal plants used for COVID-19. There is a significant 25.52 percent
decline in cultivation.

Conclusion:

This study emphasizes the need for constant production of these plants as well as a
regular outlook on the market scenario to help policymakers in the robust use of these medicinal
plants and to plan for future unforeseen disease outbreaks.
Medicinal Properties of Fenugreek: A Review
Authors: Varshney Himanshi , Siddique Yasir Hasan
Published: August 2024

Background:

Due to its numerous health benefits, fenugreek (Trigonella foenum-graecum L.) is commonly used in Ayurvedic and Traditional Chinese medicine. Its leaves and seeds contain several compounds (e.g., alkaloids, amino acids, coumarins, flavonoids, saponins, polyphenols, carbohydrates, vitamins, and other bioactive compounds). Fenugreek is used for reproductive health problems, hepatoprotective properties, and improved digestion. Studies have shown that it has anti-cancerous, cardioprotective, anti-sterility, antimicrobial, antiparasitic, anti-helminthic, and neuroprotective properties. Various studies have been carried out on animals and humans to show the effectiveness of fenugreek against various diseases.

Methods:

This review focuses on studies and clinical trials to examine the effects of fenugreek on various diseases from 1990 to 2022, using popular databases, such as Google Scholar, PubMed, and Scopus.

Results:

By altering the activity of metabolic enzymes, fenugreek stimulates insulin secretion, reduces blood sugar, and controls cholesterol synthesis. It enhances SOD, glutathione peroxidase, glutathione-S-transferase, and catalase activity to protect cellular organelles from oxidative stress. Fenugreek improves the gastric mucosa lining and secretion, which improves gastric ulcers and digestion. Fenugreek ameliorates menstrual cramps and significantly increases sperm cell counts and testosterone levels in males.

Conclusion:

Studies and clinical trials have shown the beneficial effects of fenugreek. Therefore, it could be used as a therapeutic agent against various disorders.
Benarkah teknologi informasi dan teman sebaya berhubungan dengan perilaku seksual berisiko remaja? (studi pada anak binaan pelaku asusila)
Authors: Karsiyati Karsiyati , Wicaksono Nugroho , Iftayani Itsna
Published: August 2024

Masa remaja merupakan masa peralihan anak-anak ke dewasa dimana salah satu cirinya ditandai dengan organ seksual yang mulai aktif dan berkembang. Hal tersebut menjadikan dorongan seksual pada remaja juga mulai muncul. Remaja yang tidak dapat mengontrol dorongan seksualnya berpeluang melakukan perilaku seksual berisiko, termasuk melakukan pelecehan seksual pada orang lain sehingga harus berurusan dengan hukum. Di LPKA sendiri kasus tersebut cukup mendominasi, yaitu sekitar 55,6% dari seluruh kasus yang ada. Dari berbagai faktor yang mempengaruhi perilaku seksual berisiko peneliti ingin mengetahui pengaruh faktor teman sebaya dan teknologi informasi pada perilaku seksual berisiko Andik. Kedua faktor tersebut dipilih karena peneliti melihat karakteristik remaja yang lekat dengan teman sebaya dan keterbukaan teknologi informasi dalam kehidupan sehari-harinya. Penelitian ini menggunakan desain penelitian korelasional untuk melihat hubungan antara teman sebaya dan teknologi informasi  dengan perilaku seksual berisiko. Pengambilan sampel dilakukan menggunakan metode purposive sampling pada Andik dengan kasus kesusilaan dengan sejumlah 30 partisipan. Partisipan kemudian diberikan kuesioner perilaku seksual berisiko, teman sebaya, dan teknologi informasi. Dari hasil analisis data diketahui bahwa terdapat korelasi yang signifikan antara teman sebaya serta informasi dan teknologi terhadap perilaku seksual berisiko Andik.
Efektivitas Structure Learning Approach (SLA) untuk Meningkatkan Kompetensi Guru dalam Memandirikan Siswa SD yang terReject di Wilayah KKG Kapanewon Sleman
Authors: Lidyasari Aprilia , Anggito Albi , Senen Anwar , Firmansyah Firmansyah , Kawuryan Sekar Purbarini , Mujinem Mujinem
Published: August 2024

The Covid-19 pandemic has an impact on all aspects of life, including the social life of elementary school children. This study aims to determine the effectiveness of the structure learning (SLA) approach to improve teacher competence in independent elementary school students who are rejected in the KKG Kapanewon Sleman area. This research uses quantitative research with pre-experimental method with one group pretest-posttest design which is by comparing the condition before being given treatment and the condition after being given treatment. This study involved 25 teachers who were members of the teacher working group (KKG) in Kapanewon Sleman, Yogyakarta Special Region which was held in July-September 2022. This improvement used the lecture, question and answer, discussion, simulation and project methods. The data collection technique used is observation and the structure learning approach (SLA) scale. While the technical analysis of the data using the Wilcoxon Test. The Structure Learning Approach (SLA) has 5 hierarchical intervention techniques, namely; instruction, modeling, role playing, feedback, and ownwork/applying skills outside the group setting. The results of the implementation of this training based on a pre-post questionnaire showed an increase in pre-post results from an average of 28 to an average of 41.08. While the results of data processing using SPSS obtained the value of Sig. 0.05 this indicates a significant difference between the pretest and posttest. Thus, SLA can increase the independence of rejected elementary school students
The Effect of Multiple Intelligences Based Instructional Model on Learning Outcomes IPAS Grade V in 2 Sentul Elementary School
Authors: Makantika Farahdibah Ade , Barus Yohannes Kurniawan , Muzaki Ferril Irham
Published: August 2024

The aim of the research is to see the effect of instructional models with multiple intelligences (MI) on the science and science learning outcomes of class V at SDN 2 Sentul. Researchers apply a quantitative approach, with the type of research through experimental research. The experimental group received action in the form of implementing a MI based instructional model in the learning process. And the control group did not receive special actions or apply conventional learning models. The research design applied by the researcher is a quasi experimental design in the form of a non-equivalent control group design research. In these findings, two groups were used, namely, the experimental group and the control group. The sample consisted of 25 students and 27 students in the experimental class. This instrument is in the form of a questionnaire and multiple choice test. The results explain the magnitude of Sig. there is 0.003 0.05, so Ho is rejected and Ha is accepted. In accordance with these results, it can be stated that there is an influence of instructional models with multiple intelligences (MI) on the science and science learning outcomes for class V at SDN 2 Sentul.