bluuebunny/crossref_metadata_2025 huggingface dataset:
Untersuchungen zum Schädigungspotenzial durch den Konsum von E-Zigaretten
Authors: Wiest F. , Scherzad A. , Ickrath P. , Poier N. , Hackenberg S. , Kleinsasser N.
Published: February 2021

Hintergrund

Die E‑Zigarette erfreut sich in den letzten Jahren zunehmender Beliebtheit. Die Frage nach der Toxizität ist jedoch noch nicht eindeutig geklärt, und es herrscht global Unsicherheit im Umgang mit der E‑Zigarette.

Ziel

Ziel der vorliegenden Arbeit war es, Propylenglykol, ein Hauptbestandteil der Liquide, in Bezug auf mögliche akute Entzündungsreaktionen, zyto- und genotoxische Auswirkungen auf humane Nasenschleimhautzellen zu untersuchen.

Material und Methoden

Die Nasenschleimhautzellen wurden von zehn Probanden im Air-Liquid-Interface kultiviert und anschließend mit unterschiedlichen Konzentrationen des Propylenglykols bedampft. Die Analyse erfolgte mittels Trypanblau-Test, Comet-Assay, Mikrokerntest und IL-6- und IL-8-Sandwich-ELISA.

Ergebnis

Der Trypanblau-Test zeigte keine Reduktion der Vitalität. Im Sandwich-ELISA konnte kein Anstieg der IL-6- und IL-8-Konzentrationen nachgewiesen werden. Im Comet-Assay zeigte das Olive Tail Moment eine Schädigung im Vergleich zur Negativkontrolle in allen untersuchten Konzentrationen. Zudem zeigte sich eine dosisabhängige Schädigung. Im Mikrokerntest konnte ein Unterschied zwischen dem Reinstoff und der Negativkontrolle gefunden werden.

Schlussfolgerung

Es zeigten sich möglicherweise reparable DNS-Schädigungen im Comet-Assay. Im Mikrokerntest konnten diese nur in der Reinstoffkonzentration bestätigt werden. Es sollte ein restriktiver Umgang mit der E‑Zigarette erfolgen, bis insbesondere Langzeitstudien vorliegen. Zudem ist eine eindeutige Deklaration der Inhaltsstoffe der Liquide durch die Hersteller zu fordern, um weitergehende Schädigungspotenziale untersuchen zu können.
Measurement of the alcohol biomarker phosphatidylethanol (PEth) in dried blood spots and venous blood—importance of inhibition of post-sampling formation from ethanol
Authors: Beck Olof , Mellring Maria , Löwbeer Christian , Seferaj Sabina , Helander Anders
Published: February 2021

Phosphatidylethanol (PEth) is a group of phospholipids formed in cell membranes following alcohol consumption by action of the enzyme phospholipase D (PLD). PEth measurement in whole blood samples is established as a specific alcohol biomarker with clinical and forensic applications. However, in blood specimens containing ethanol, formation of PEth may continue after sampling leading to falsely elevated concentrations. This study evaluated the use of dried blood spot (DBS) and microsampling specimens to avoid post-sampling formation of PEth. Filter paper cards and three commercial devices for volumetric microsampling of finger-pricked blood were assessed, using PEth-negative and PEth-positive whole blood fortified with 2 g/L ethanol. PEth (16:0/18:1) was measured by LC–MS/MS. Post-sampling formation of PEth occurred in wet blood and in the volumetric devices, but not filter paper cards, when stored at room temperature for 48 h. Addition of an inhibitor of PLD, sodium metavanadate (NaVO3), eliminated post-sampling formation during storage and drying. In conclusion, the present study confirmed previous observations that PEth can be formed in blood samples after collection, if the specimen contains ethanol. The results further demonstrated that post-sampling formation of PEth from ethanol also occurred with commercial devices for volumetric dried blood microsampling. In order for a PEth result not to be questioned, it is recommended to use a PLD inhibitor, whether venous blood is collected in a vacutainer tube or finger-pricked blood is obtained using devices for dried blood microsampling.

Graphical abstract
Convergence Rates for the Quantum Central Limit Theorem
Authors: Becker Simon , Datta Nilanjana , Lami Ludovico , Rouzé Cambyse
Published: February 2021

Various quantum analogues of the central limit theorem, which is one of the cornerstones of probability theory, are known in the literature. One such analogue, due to Cushen and Hudson, is of particular relevance for quantum optics. It implies that the state in any single output arm of an n-splitter, which is fed with n copies of a centred state $$\rho $$
ρ
with finite second moments, converges to the Gaussian state with the same first and second moments as $$\rho $$
ρ
. Here we exploit the phase space formalism to carry out a refined analysis of the rate of convergence in this quantum central limit theorem. For instance, we prove that the convergence takes place at a rate $$\mathcal {O}\left( n^{-1/2}\right) $$

O

n

-
1
/
2

in the Hilbert–Schmidt norm whenever the third moments of $$\rho $$
ρ
are finite. Trace norm or relative entropy bounds can be obtained by leveraging the energy boundedness of the state. Via analytical and numerical examples we show that our results are tight in many respects. An extension of our proof techniques to the non-i.i.d. setting is used to analyse a new model of a lossy optical fibre, where a given m-mode state enters a cascade of n beam splitters of equal transmissivities $$\lambda ^{1/n}$$

λ

1
/
n

fed with an arbitrary (but fixed) environment state. Assuming that the latter has finite third moments, and ignoring unitaries, we show that the effective channel converges in diamond norm to a simple thermal attenuator, with a rate $$\mathcal {O}\Big (n^{-\frac{1}{2(m+1)}}\Big )$$

O

(

n

-

1

2
(
m
+
1
)

)

. This allows us to establish bounds on the classical and quantum capacities of the cascade channel. Along the way, we derive several results that may be of independent interest. For example, we prove that any quantum characteristic function $$\chi _\rho $$

χ
ρ

is uniformly bounded by some $$\eta _\rho <1$$

η
ρ

<
1

outside of any neighbourhood of the origin; also, $$\eta _\rho $$

η
ρ

can be made to depend only on the energy of the state $$\rho $$
ρ
.
Introducing the Node Reporting and Data System 1.0 (Node-RADS): a concept for standardized assessment of lymph nodes in cancer
Authors: Elsholtz Fabian H. J. , Asbach Patrick , Haas Matthias , Becker Minerva , Beets-Tan Regina G. H. , Thoeny Harriet C. , Padhani Anwar R. , Hamm Bernd
Published: February 2021

“Node-RADS” addresses the lack of consensus in the radiologic assessment of lymph node involvement by cancer and meets the increasing demand for structured reporting on the likelihood of disease involvement. Node Reporting and Data System 1.0 (Node-RADS) systematically classifies the degree of suspicion of lymph node involvement based on the synthesis of established imaging findings. Straightforward definitions of imaging findings for two proposed scoring categories “size” and “configuration” are combined into assessment categories between 1 (“very low likelihood”) and 5 (“very high likelihood”). This scoring system is suitable for assessing likely involvement of lymph nodes on CT and MRI scans. It can be applied at any anatomical site, and to regional and non-regional lymph nodes in relation to a primary tumor location. Node-RADS will improve communication with referring physicians and promote the consistency of reporting for primary staging and in response assessment settings.

Key Points

• Node-RADS standardizes reporting of possible cancer involvement of regional and distant lymph nodes on CT and MRI.

• Node-RADS proposes the scoring categories “size” and “configuration” for assigning the 5-point Node-RADS score from 1 (“very low likelihood”) to 5 (“very high likelihood”).

• Node-RADS aims to increase consensus among radiologists for primary staging and in response assessment settings.
Trace element profile and incidence of type 2 diabetes, cardiovascular disease and colorectal cancer: results from the EPIC-Potsdam cohort study
Authors: Cabral Maria , Kuxhaus Olga , Eichelmann Fabian , Kopp Johannes F. , Alker Wiebke , Hackler Julian , Kipp Anna P. , Schwerdtle Tanja , Haase Hajo , Schomburg Lutz , Schulze Matthias B.
Published: February 2021

Purpose

We aimed to examine the prospective association between manganese, iron, copper, zinc, iodine, selenium, selenoprotein P, free zinc, and their interplay, with incident type 2 diabetes (T2D), cardiovascular disease (CVD) and colorectal cancer (CRC).

Methods

Serum trace element (TE) concentrations were measured in a case-cohort study embedded within the EPIC-Potsdam cohort, consisting of a random sub-cohort (n = 2500) and incident cases of T2D (n = 705), CVD (n = 414), and CRC (n = 219). TE patterns were investigated using principal component analysis. Cox proportional hazard models were fitted to examine the association between TEs with T2D, CVD and CRC incidence.

Results

Higher manganese, zinc, iodine and selenium were associated with an increased risk of developing T2D (HR Q5 vs Q1: 1.56, 1.09–2.22; HR per SD, 95% CI 1.18, 1.05–1.33; 1.09, 1.01–1.17; 1.19, 1.06–1.34, respectively). Regarding CVD, manganese, copper and copper-to-zinc ratio were associated with an increased risk (HR per SD, 95% CI 1.13, 1.00–1.29; 1.22, 1.02–1.44; 1.18, 1.02–1.37, respectively). The opposite was observed for higher selenium-to-copper ratio (HR Q5 vs Q1, 95% CI 0.60, 0.39–0.93). Higher copper and zinc were associated with increasing risk of developing CRC (HR per SD, 95% CI 1.29, 1.05–1.59 and 1.14, 1.00–1.30, respectively). Selenium, selenoprotein P and selenium-to-copper-ratio were associated to decreased risk (HR per SD, 95% CI 0.82, 0.69–0.98; 0.81, 0.72–0.93; 0.77, 0.65–0.92, respectively). Two TE patterns were identified: manganese–iron–zinc and copper–iodine–selenium.

Conclusion

Different TEs were associated with the risk of developing T2D, CVD and CRC. The contrasting associations found for selenium with T2D and CRC point towards differential disease-related pathways.
“Guboow”—child abuse or traditional medical treatment? a case report
Authors: Lange-Herr N. , Rindlisbacher A. , Romano F. , Jackowski C.
Published: February 2021

The examination of children suspected of being abused poses a great challenge for forensic pathologists. The risk of misjudgment is high and can have serious consequences for the child and the family. In unclear cases, an assessment should always be carried out on an interdisciplinary basis with the involvement of the relevant disciplines such as pediatrics, dermatology, or radiology. We present the case of a 2.5-year-old boy who was presented by his parents at the Pediatric Emergency Department of a Swiss University Hospital due to fever and weight loss. During the physical examination, conspicuous findings on the abdomen were present, and the responsible emergency physicians informed the child protective services. A clinical forensic examination occurred on behalf of the child protection services. The abdomen of the child showed several symmetrical scars. The initial questioning of the parents did not provide clear information about the origin of the injuries. Further professional questioning of the family by the child protective services concluded that the injuries were the result of a traditional medical treatment in Somalia, which occurred several weeks before.
A Local Barycentric Version of the Bak–Sneppen Model
Authors: Kennerberg Philip , Volkov Stanislav
Published: February 2021

We study the behaviour of an interacting particle system, related to the Bak–Sneppen model and Jante’s law process defined in Kennerberg and Volkov (Adv Appl Probab 50:414–439, 2018). Let$$N\ge 3$$N≥3vertices be placed on a circle, such that each vertex has exactly two neighbours. To each vertex assign a real number, calledfitness(we use this term, as it is quite standard for Bak–Sneppen models). Now find the vertex which fitness deviates most from the average of the fitnesses of its two immediate neighbours (in case of a tie, draw uniformly among such vertices), and replace it by a random value drawn independently according to some distribution$$\zeta $$ζ. We show that in case where$$\zeta $$ζis a finitely supported or continuous uniform distribution, all the fitnesses except one converge to the same value.
The role of motivational profiles in learning problem-solving and self-assessment skills with video modeling examples
Authors: Wijnia Lisette , Baars Martine
Published: February 2021

In the current study, we examine the role of situation-specific motivational profiles in the effectiveness of video modeling examples for learning problem-solving and self-assessment accuracy in the domain of biology. A sample of 342 secondary school students participated in our study. Latent profile analysis resulted in four motivational profiles: (a) good-quality profile (high autonomous motivation, moderate introjected and external motivation), (b) moderately positive profile (moderate motivation levels with relatively higher autonomous motivation), (c) moderately negative profile (moderate motivation levels with relatively higher external motivation), and (d) poor-quality profile (moderate external, low autonomous motivation). Findings showed students with good-quality or moderately positive profiles learned more from the video modeling in terms of problem-solving and self-assessment accuracy than students with poor-quality or moderately negative profiles. Furthermore, students with a moderately negative profile outperformed students with a poor-quality profile on problem-solving and self-assessment accuracy. Results further indicated that students with good-quality and moderately positive profiles experienced studying the video modeling examples as less effortful than students with poor-quality or moderately negative profiles. Overall, our results demonstrated that knowing about students’ motivational profiles could help explain differences in how well students learn problem-solving as well as self-assessment skills from watching video modeling examples.
Stochastic sensitivity of bull and bear states
Authors: Jungeilges Jochen , Maklakova Elena , Perevalova Tatyana
Published: February 2021

We study the price dynamics generated by a stochastic version of a Day–Huang type asset market model with heterogenous, interacting market participants. To facilitate the analysis, we introduce a methodology that allows us to assess the consequences of changes in uncertainty on the dynamics of an asset price process close to stable equilibria. In particular, we focus on noise-induced transitions between bull and bear states of the market under additive as well as parametric noise. Our results are obtained by combining the stochastic sensitivity function (SSF) approach, a mixture of analytical and numerical techniques, due to Mil’shtein and Ryashko (1995) with concepts and techniques from the study of non-smooth 1D maps. We find that the stochastic sensitivity of the respective bull and bear equilibria in the presence of additive noise is higher than under parametric noise. Thus, recurrent transitions are likely to be observed already for relatively low intensities of additive noise.
The Genetics of Atypical Femur Fractures—a Systematic Review
Authors: Zhou Wei , van Rooij Jeroen G. J. , Ebeling Peter R. , Verkerk Annemieke J. M. H. , Zillikens M. Carola
Published: February 2021

Purpose of Review

Atypical femur fractures (AFFs) are rare subtrochanteric or diaphyseal fractures regarded as side effects of bisphosphonates (BPs), possibly with a genetic background. Here, we summarize the most recent knowledge about genetics of AFFs.

Recent Findings

AFF has been reported in 57 patients with seven different monogenic bone disorders including hypophosphatasia and osteogenesis imperfecta; 56.1% had never used BPs, while 17.5% were diagnosed with the disorder only after the AFF. Gene mutation finding in familial and sporadic cases identified possible AFF-related variants in the GGPS1 and ATRAID genes respectively. Functional follow-up studies of mutant proteins showed possible roles in AFF. A recent small genome-wide association study on 51 AFF cases did not identify significant hits associated with AFF.

Recent findings have strengthened the hypothesis that AFFs have underlying genetic components but more studies are needed in AFF families and larger cohorts of sporadic cases to confirm previous results and/or find novel gene variants involved in the pathogenesis of AFFs.
Test for Mobile phone dependence: psychometric properties and confirmatory factor analysis
Authors: Vezzoli Michela , Colombo Aurora , Marano Alessandra , Zoccatelli Giorgia , Zogmaister Cristina
Published: February 2021

The Test of Mobile Phone Dependence (TMD) is a questionnaire designed for appraising the main dimensions of problematic smartphone use in adolescence. This study evaluates the factor structure and psychometric properties of the TMD on a sample of 813 Italian middle and high school students. The original three-factor model (Abstinence, Lack of Control, and Tolerance) of the TMD was tested through a Confirmatory Factor Analysis. The results of the goodness of fit indices indicated a satisfactory solution. The overall TMD score showed a good level of internal consistency and good construct validity with the duration of use, age of possession of the first mobile phone, perceived self-efficacy, gender, and participants’ age. The relationship between TMD and Nomophobia was also explored. Overall, the results indicate that the TMD is a valid and reliable assessment tool in Italian culture. However, reliability issues emerged on the subfactor Lack of Control. This indicates that the scores on this subfactor should be treated with caution.
GIS-based rockfall hazard zones modeling along the coastal Gulf of Aqaba Region, Egypt
Authors: Omran Adel , Fahmida Kanij , Schröder Dietrich , Arnous Mohamed O. , El-Rayes Ahmed E. , Hochschild Volker
Published: February 2021

Rockfall is a natural hazard in mountainous areas not to be underestimated. Mass activities differing in rock volume may cause considerable economic damage. Accomplishing qualitative appraisal of high-potential zones for rockfall is a first step towards implementing mitigation strategies. Nowadays, Geographical Information Systems (GIS) are the state-of-the-art tool for a fast and economic approach of identifying potential hazard zones rather than using conventional mapping with in-situ field data. Primarily, current research focuses on designing and implementing user-friendly tools delineating potential rockfall hazard zonation (RHZ). The constructed model examines triggering factors like slope, aspect, elevation, lithology, structural lineament, rainfall intensity, and seismic activity focal depth of a mountainous coastal region (Gulf of Aqaba, Egypt). The extracted geomorphological parameters were based on a high-resolution TanDEM-X Digital Elevation Model. The enhanced Landsat ETM + 7 was used to generate the lithological and structural lineament parameters, while the rainfall data were collected from NASA project tool. The zonation model was implemented by means of ESRI’s ArcGIS Pro ModelBuilder. Google Earth Pro orthophotos compared with the generated rockfall hazard zonation map indicate the potential RHZ with high reliability. The achieved results show that 15 % of the study area qualifies as a high rockfall hazard zone. As the RHZs generated by the model depend on the input data and the selected rating scores and weights, obtaining ground truth is essential to get a trustworthy result. Finally, this study recommends employing the built RHZ model on similar terrains worldwide to support decision-makers involving any sustainable development projects.
Distribution, Mobility and Fate of Trace Elements in an Estuarine System Under Anthropogenic Pressure: the Case of the Karstic Timavo River (Northern Adriatic Sea, Italy)
Authors: Pavoni Elena , Crosera Matteo , Petranich Elisa , Faganeli Jadran , Klun Katja , Oliveri Paolo , Covelli Stefano , Adami Gianpiero
Published: February 2021

The accumulation of contaminants and their potential mobility represent two of the main environmental issues facing coastal environments. Sediments often act as “reservoirs” of contaminants, including potentially toxic trace elements, but they can also be considered a secondary source of contamination due to remobilisation processes at the sediment-water interface which may affect the quality of the coastal water and aquatic biota. This research aims to provide a geochemical characterisation of the estuarine system of the Timavo/Reka River, focusing on the occurrence of trace elements in different environmental matrices with the purpose of highlighting potential critical conditions in terms of environmental quality. The surface sediments were found to be enriched in several trace elements especially in the innermost sector of the area. There, sulphate-reductive conditions in the bottom saltwater testify to potential anoxia at the sediment-water interface, driving trace element accumulation in the residual fraction of the sediments. However, Fe and Mn redox behaviour appears to play a crucial role in the recycling of dissolved trace elements in the water column. With the lone exception of the saltwater in the innermost sector, trace elements were found to be mainly associated with suspended particles due to oxidation and precipitation processes, whereas a common lithogenic origin was identified for Cr, Ni, and Co, which are significantly correlated both in the surface sediments and in the suspended particles.
Resonance features of rock slope with anti-dip weak interlayer under seismic actions
Authors: Wang Tong , Huang Jingli , Lang Qiuling , Liu Lisha
Published: February 2021

Resonance avoidance is an important topic in engineering seismic design. However, there is little report on the resonance features of rock slopes with anti-dip weak rock layers under seismic actions. Through finite-element method, this paper carries out modal analysis and harmonic response analysis on a slope, captures the natural frequencies and vibration modes of the slope, and plots the resonance curves about displacement frequency relationships. The results show that slope resonance is greatly affected by damping ratio: the greater the damping ratio, the lower the resonance peak; the inverse is also true. This means that weak and broken rock mass is capable of absorbing shocks, but not necessarily easy to be damaged. On the contrary, broken rock mass has poor mechanical performance and is prone to damage under small vibration. Besides, the resonance effect of the slope is mainly excited by the natural frequencies of the first three orders; the vertical resonance displacement peaked at about 1.1 Hz, while the horizontal resonance displacement peaked at about 1.38 Hz. From the vibration modes and frequency response curves, the resonance peak of the slope is amplified in the vertical direction and on the free face, and the maximum resonance displacement appears on the surface of the slope, indicating that the strongest resonance occurs on slope surface. This research fully clarifies the stability and dynamic response law of rock slopes with anti-dip weak interlayer under seismic actions, laying a solid basis for the mic fortification, landslide prediction, and landslide control of slopes.
Phosphorus load in outdoor areas for laying hens and capacity of phosphorus retaining materials to reduce the environmental impact
Authors: Aronsson Helena , Wahlund Lotten , Lovang Malin , Hellstrand Ebba , Odelros Åsa , Salomon Eva
Published: February 2021

This study investigated manure loads in outdoor paddocks for laying hens and the capacity of two phosphorus (P) retaining materials for reducing leaching from manure in areas with high hen density. Inventories on two commercial farms during 2 years (2017 and 2018) of the impact of hens (groups of 3000 hens) on vegetation, as a proxy for land use by hens, showed that 16–21% of outdoor area in grassland paddocks and 22–39% of area in a forest paddock were used by the hens. Sand and limestone were tested as P retention materials in areas with high manure load in a field study during the outdoor season for laying hens (May 1 to October 31 in 2018). The materials were placed on the ground (0.2 m deep bed, 3.3 m wide) outside the pop-hole in paddocks with 76 hens. The average numbers of hens outdoors were recorded at 9 am and 3 pm daily. There was no significant difference between the materials concerning distribution of hens, and they seemed not to prefer any material more than the other. When cylinders containing the spent materials were exposed to simulated rainfalls in a laboratory study, the P concentrations in drainage water were high for all materials, including a control with gravel (58–136 mg PO4-P L−1 and 130–197 mg total-P L−1). On average, 14% of manure P retained in the sand and limestone materials was leached after 100 mm of simulated rainfall. Thus, these materials may act as physical filters for P in manure, but to reduce the risk of P losses to waters during the following winter, they need to be removed from the paddocks and preferably used as potential P fertilizers on arable land.
Water quality assessment of the Tano Basin in Ghana: a multivariate statistical approach
Authors: Obiri Samuel , Addico Gloria , Mohammed Saada , Anku Wilson William , Darko Humphry , Collins Okrah
Published: February 2021

Multivariate statistical techniques including principal component and factor analyses were applied in this study to assess the quality of surface water from Tano basin in Ghana. The water samples were obtained from three monitoring stations from January to October 2016. The obtained data set was analysed using multivariate statistical methods. The results obtained from Rho Spearman's correlation revealed that at P < 0.05 two-tailed, a positive correlation between pH and total dissolved solids, pH and alkalinity, pH and electrical conductivity, pH and major anions and cations such as SO4, F, Ca, K, Na and Mg was established. However, negative correlation existed between pH-colour, pH-turbidity and total suspended solids. The results of the principal component analysis show that the five principal components explain more than 91.57% of the total variance and hence can be relied upon for identification of the main sources of variation in the physicochemical properties of the water samples. Principal component 1 embodies about 54.26% of the variance and possesses a high loading for electrical conductivity, Na, Ca, K, Mg. Principal component 2, which also explains 33.94% of the total variance, holds high loadings for pH, SO4, HCO3, and total alkalinity. Component 3 also shows high loadings for TDS, TSS and conductivity, which account for 3.378% of the variation in the hydrochemistry. Components 4 and 5 show a joint influence of anthropogenic activities and partial ecological recovery system of the river and its basin which influence the overall water quality within the basin.
Evidence-based uncertainty: do implant-related properties of titanium reduce the susceptibility to perioperative infections in clinical fracture management? A systematic review
Authors: Tanner Michael C. , Fischer Christian , Schmidmaier Gerhard , Haubruck Patrick
Published: February 2021

Background

Implant-associated infections (IAI) remain a challenging complication in osteosynthesis. There is no consensus or clear evidence whether titanium offers a relevant clinical benefit over stainless steel.

Purpose

In this systematic review, we sought to determine whether the implant properties of titanium reduce the susceptibility to IAI compared to stainless steel in fracture management.

Methods

A systematic literature search in German and English was performed using specific search terms and limits. Studies published between 1995 and 1st June 2020 in the Cochrane library, MEDLINE and Web of Science databases were included. Only clinical studies comparing titanium and stainless steel implants regarding the susceptibility to infections were selected for detailed review.

Results

Five studies out of 384 papers were identified and reviewed. From the studies meeting inclusion criteria one study was a systematic review, two studies were randomized controlled studies (RCT) and two studies were of retrospective comparative nature of level IV evidence.

Conclusion

Our results show that currently, no proven advantage for titanium implants in respect to IAI can be seen in contemporary literature. Implants preserving periosteal blood-flow and minimising soft-tissue trauma show statistically significant benefits in reducing the incidence of IAI. Clinical studies providing reliable evidence regarding the influence of titanium implants on IAI and investigating the susceptibility of titanium to infection are necessary
Challenged in Geneva: WTO Litigation Experience and the Design of Preferential Trade Agreements
Authors: Wüthrich Simon , Elsig Manfred
Published: February 2021

What explains the design of international institutions? Existing research has largely neglected how experience in cooperation in one set of international institutions impacts on design choices made by states in other globally-oriented institutions. We contribute to this evolving debate by analyzing spillovers in experience in international trade. We argue that countries' track record of interaction in multilateral trade disputes affects the design of their preferential trade agreements (PTAs). If a country participates in a complaint against a prospective PTA partner at the World Trade Organization (WTO), the challenge in Geneva alerts the defendant's import-competing industries with respect to potential challenges under the planned PTA. As a result, these industries exert pressure on their government to preserve leeway under the future treaty, leading to increased flexibility and a lower level of enforcement in the PTA. We find support for our hypotheses in an empirical analysis of 347 PTAs concluded post 1990.
More than amnesia: prospective cohort study of an integrated novel assessment of the cognitive and behavioural features of PTA
Authors: Hennessy Maria J. , Delle Baite Lorryn , Marshman Laurence A. G.
Published: February 2021

Background and Objective:

Post-traumatic amnesia (PTA) is an early significant stage of recovery from traumatic brain injury (TBI). Current prospective PTA scales do not assess the full range of PTA symptomatology. This study conducted a novel integrated assessment of cognition and behaviour during PTA.

Method:

Twenty-four moderate-to-severe TBI participants in PTA and 23 TBI controls emerged from PTA were matched for age, gender, and years of education. All completed PTA measures (Galveston Orientation and Amnesia Test: GOAT, Westmead Post-traumatic Amnesia Scale: WPTAS), a cognitive battery; and behaviour ratings scored by 2 independent raters (informant and staff).

Results:

Significantly poorer performance was found during PTA for attention, processing speed, delayed verbal free recall and recognition, and visual learning. A large effect size was found for category fluency only. Behaviour ratings were significantly higher during PTA. Five behaviours were rated as high frequency (>50%) by both raters: Inattention, Impulsivity, Sleep Disturbance, Daytime Arousal, and Self-Monitoring. Prospective PTA measures produced significantly different duration estimates from 2 days (GOAT vs. WPTAS 1st day) to 9 days (WPTAS 1st day vs. 3-day). The WPTAS correlated most highly with processing speed and language tasks; whilst the GOAT correlated most highly with language and executive control of verbal memory.

Conclusion:

New prospective measures are needed that integrate core cognitive and behavioural features are brief, easy to administer, and capable of measuring emergence. The term PTA is a misnomer that requires revision to better accommodate the clinical syndrome.
Energy and protein intake in the Colombian population: results of the 2015 ENSIN population survey
Authors: Herrán Oscar F. , Gamboa-Delgado Edna M. , Zea María Del Pilar
Published: February 2021

The present study was aimed at (1) the differences between current weightv.ideal weight, (2) total energy intake and comparing it with required energy (Rkeer), (3) absolute protein intake in g/kg per d and g/1000 calories, (4) how energy and protein intake relate to the nutritional status of the subjects in terms of overall overweight (OEW) [overweight + obesity] and conservative overweight (CEW) [obesity] and (5) the contribution (%) of protein to total energy intake based on the acceptable macronutrient distribution range (AMDR). A dietary study was carried out in Colombia with 29 259 subjects between 1 and 64 years of age, based on cross-sectional data collected in 2015 by a 24-h dietary recall (24HR) administered as part of the National Nutrition Survey. Energy and protein intake did not differ by nutritional status. In the general population, energy intake was 2117 kcal/d (95 % CI 1969, 2264). The total protein intake was 64⋅3 g/d (95 % CI 61⋅4, 67⋅3). Adequate energy intake ranged from 90 to 100 %, except for the 1–4-year-old group, which ranged from 144 to 155 %. Protein intake was 1⋅64 g/kg per d (95 % CI 1⋅53, 1⋅75). The mean AMDR for protein to total energy intake was 13⋅3 % (95 % CI 12⋅9, 13⋅7). Excess weight began during the first 4 years of age. In conclusion, it is worth reviewing and updating energy and protein intake recommendations and dietary guidelines for the Colombian population and designing and modifying public policy.
Emergence and Development of Pottery in the Andean Early Formative Period: New Insights from an Improved Wairajirca Pottery Chronology at the Jancao Site in the Huánuco Region, Peru
Authors: Kanezaki Yuko , Omori Takayuki , Tsurumi Eisei
Published: February 2021

This article presents a high-resolution chronology of Wairajirca pottery in the Huánuco basin, which has been identified as a frontier region between the Andean highlands and the Amazonian rain forests: its pottery is known for having mixed features from both areas. However, the lack of fine-grained pottery and radiocarbon datasets has handicapped comparative studies’ attempts to track in detail its early development process. Our new high-resolution chronology of Wairajirca pottery is based on stratigraphic excavation data, a detailed ceramic typology, and a Bayesian analysis of the radiocarbon date from the Jancao site. The five-staged ceramic sequence from the late eighteenth to late twelfth century cal BC displays specific features of this development, including radical changes in vessel type over several centuries and connections with other pottery traditions. The earliest phase shows close relation with highlands traditions, whereas the influence of tropical rain forest patterns intensified in later phases alongside the continuation of local pottery traditions. This indicates that frontier dynamics based on fluid interactions across different ecological zones and regional sociopolitical movements played a crucial role in this long-term social process.
Vitamin and mineral supplement exposures: cases reported to Australia’s largest Poisons Information Centre, 2014–2015 to 2018–2019
Authors: Luckock Usha , Harnett Joanna , Cairns Rose
Published: February 2021

Vitamin and mineral supplements (VMS) are widely available and commonly used. Little is known about patterns of poisoning exposures to VMS in the Australian population. We performed a retrospective study of calls to the New South Wales Poisons Information Centre (NSWPIC), July 2014–June 2019. NSWPIC is Australia’s largest PIC, taking approximately 100 000 calls/year (50 % of Australian poisoning calls) from healthcare professionals and members of the public. We conducted additional analyses on Fe exposures due to their high risk of acute toxicity. There were 10 944 VMS exposures reported to NSWPIC during the study period, increasing 9·6 % per annum over a 5-year period (95 % CI, 7·2, 12·1 %). Toddlers (1–4 years) accounted for 41·5 % (4546) of cases. Agents most commonly involved were multivitamins (n 3610), vitamin D (n 2080), Fe (n 1533) and Mg (n 804). In 17·7 % (1934) of cases, the call originated from hospital or the patient was referred to hospital by NSWPIC. Fe exposures increased by 14·0 % per year (95 % CI, 9·5, 18·5 %), and most were associated with high-strength products (> 45 mg elemental Fe per unit dose, n 1036). Fe exposures were hospitalised in 38 % of cases (n 583). We conclude that VMS exposures are increasing in Australia. Although most exposures can be managed at home, many required hospitalisation. Fe exposures are increasing and had higher rates of hospitalisation than other agents. VMS are often considered safe and without the potential for adverse effects, highlighting the importance of public education into the potential risks of misuse of these products.
Out of an Abundance of Caution: COVID-19 and Health Risk Frames in Canadian News Media
Authors: Wallace Rebecca , Lawlor Andrea , Tolley Erin
Published: February 2021

Although Canada's first documented case of COVID-19 appeared in mid-January 2020, it was not until March that messaging about the need to contain the virus heightened. In this research note, we document the use of the media's construction of risk through framing in the early stages of the pandemic. We analyze three dimensions of the health risk narratives related to COVID-19 that dominated Canadians’ concerns about the virus. To capture these narratives, we examine print and online news coverage from two nationally distributed media sources. We assess these frames alongside epidemiological data and find there is a clear link between media coverage, epidemiological data and risk frames in the early stages of the pandemic. It appears that the media relied on health expertise and political sources to guide their coverage and was responsive to the public health data presented to Canadians.
FROM COLONIALISM TO REGIONALISM: THE YAOUNDÉ CONVENTIONS (1963–1974)
Authors: Lima Sakr Rafael
Published: February 2021

How was ‘international trade’ between former European empires and their former colonies in Africa governed after decolonisation? In the 1960s, the vast majority of African countries became independent, and so a new arrangement was necessary to govern their economic relations with Europe. The Yaoundé Conventions were then concluded between the European Community (EC) and the bloc of postcolonial African countries. Specialised literature provides comprehensive accounts of the Yaoundé Conventions. However, little is known about the role of law and lawyers in their making and governance. Part of this story concerns political and intellectual struggles in the legal profession about which projects, ideas, and norms would be applicable. Another part concerns the work of lawyers to organise those policies, theories and visions into an emerging conception and to employ it to influence the production and management of the Yaoundé Conventions. This article combines historical and socio-legal approaches to show that a distinct legal conception of regional trade agreements—called here the ‘development framework’—was pivotal to the design and application of the Yaoundé Conventions. This conception was primarily advanced and persuasively used by European and African lawyers. This contrasts with the conventional view that trade agreements are variations on a single legal concept. It is concluded that EC–Africa regionalism was a singular experiment, due significantly to the unique features of this legal conception.
What is the Point of Being Your True Self? A Genealogy of Essentialist Authenticity
Authors: Leuenberger Muriel
Published: February 2021

This paper presents a functional genealogy of essentialist authenticity. The essentialist account maintains that authenticity is the result of discovering and realizing one's ‘true self’. The genealogy shows that essentialist authenticity can serve the function of supporting continuity in one's individual characteristics. A genealogy of essentialist authenticity is not only methodologically interesting as the first functional genealogy of a contingent concept. It can also deepen the functional understanding of authenticity used in neuroethics, provide a possible explanation for the prevalence of the idea of an essentialist true self and justify the use of the ideal of authenticity. First, essentialist authenticity is defined and explained through the work of Jean-Jacques Rousseau. Second, a general need to have steady characteristics is derived from basic human practices. Third, circumstances that make it more challenging to steady oneself are identified and shown to have become more prevalent in the age of modernity when the ideal of authenticity emerged. Finally, it is shown how essentialist authenticity helps to steady the self.
From washing hands to washing consciences and polishing reputations
Authors: Légeret Matthieu , Hoffrage Ulrich
Published: February 2021

While Lee and Schwarz propose grounded procedures of separation as an explanation for physical cleansing in various domains (e.g., washing one's hands), we suggest that separation can also account for behavioral cleansing aimed at washing consciences and polishing reputations. We discuss this extension in terms of degrees of behavioral cleansing, motivations, and intentions behind cleansing, and social settings.
The impact of grounded procedures can vary as a function of perceived thought validity, meaning, and timing
Authors: Briñol Pablo , Petty Richard E.
Published: February 2021

Cleansing (separation) inductions reduce the impact of negative and positive reactions, whereas connection manipulations magnify them. We suggest that grounded procedures can produce these effects by affecting the perceived validity of thoughts. In accord with the self-validation theory, we also note the importance of considering how moderators, such as the meaning of the action and the timing of inductions, affect outcomes.
Psychology of cleansing through the prism of intersecting object histories
Authors: Ekves Zachary , Prystauka Yanina , Davis Charles P. , Yee Eiling , Altmann Gerry T. M.
Published: February 2021

We link cleansing effects to contemporary cognitive theories via an account of event representation (intersecting object histories) that provides an explicit, neurally plausible mechanism for encoding objects (e.g., the self) and their associations (with other entities) across time. It explains separation as resulting from weakening associations between the self in the present and the self in the past.
The role of goal-generalization processes in the effects of grounded procedures
Authors: Wyer Robert S.
Published: February 2021

This commentary provides an interpretation of the effects of grounded procedures in terms of the goal-generalization processes involved in coping with negative feelings and identifies some implications that might not yet have been considered.
Grounded separation: can the sensorimotor be grounded in the symbolic?
Authors: Gilead Michael , Trope Yaacov , Liberman Nira
Published: February 2021

According to Lee and Schwarz, the sensorimotor experience of cleansing involves separating one physical entity from another and grounds mental separation of one psychological entity from another. We propose that cleansing effects may result from symbolic cognition. Instead of viewing abstract meanings as emerging from concrete physical acts of cleansing, this physical act may be appended with pre-existing, symbolic meaning.
Teaching English as a lingua franca in China
Authors: Yu Xia , Liu Chengyu
Published: February 2021

The last decade has witnessed a significant increase of research on English as a lingua franca (ELF) as today's world becomes progressively more globalized (Lei & Liu, 2018). However, studies on ELF in the Chinese contexts remain sparse although linguistic research in China has kept pace with the development of international linguistic academia. Moreover, many researchers studying ELF-informed teaching in China are either non-Chinese scholars or researchers working in countries other than China (Si, 2019). In other words, this newly emerged field of research has not yet been widely embraced by Chinese scholars, nor its paradigm has been promoted in English education while traditional native-English-based teaching has been challenged and initiatives have been taken to promote English education within the ELF paradigm in many countries in the expanding circle (see e.g., Sifakis & Tsantila, 2019). In this paper, we address the issue through identifying various hindrances to teaching ELF in Chinese classroom and analyzing the factors leading to the difficulties and problems with implementing the ELF-informed teaching in Chinese context. Following this, we explore the prospects for taking advantage of the pedagogical value of ELF research in the foreseeable future.
Divergence and quasi-isometry classes of random Gromov’s monsters
Authors: GRUBER DOMINIK , SISTO ALESSANDRO
Published: February 2021

We show that Gromov’s monsters arising from i.i.d. random labellings of expanders (that we call random Gromov’s monsters) have linear divergence along a subsequence, so that in particular they do not contain Morse quasigeodesics, and they are not quasi-isometric to Gromov’s monsters arising from graphical small cancellation labellings of expanders.

Moreover, by further studying the divergence function, we show that there are uncountably many quasi-isometry classes of random Gromov’s monsters.
A rare case of congenital heart disease: anomalous origin of coronary artery from innominate artery with coronary fistula and truncus arteriosus
Authors: Li Wenlei , Li Jianbin , Chen Xinxin
Published: February 2021

Anomalous origin of a single coronary artery arising from the innominate artery associated with coronary artery fistula and truncus arteriosus is extremely rare. We found this anomaly in a 16-month-old infant-girl who received Rastelli procedure during the operation. The three defects described above are rarely found together; indeed, such a case as ours may be the first reported in the literature.
Day case angioplasty in a secondary care setting – initial experience
Authors: Rodway Alexander , Stafford Michelle , Wilding Sophie , Ntagiantas Nikolaos , Patsiogiannis Vasileios , Allan Charlotte , Field Ben , Clark James , Casal Felipe Pazos , Pankhania Ajay , Loosemore Thomas , Heiss Christian
Published: February 2021

Summary: Background: Peripheral artery disease presents an increasing healthcare burden worldwide. Day-case angioplasty in a secondary care setting can be a safe and effective means of meeting the growing demand for lower limb revascularisation. We evaluated the safety and efficacy of a day-case-based angioplasty service in a UK district general hospital. Patients and methods: Consecutive patients undergoing endovascular revascularisation between August 2018–February 2020 were analysed retrospectively. All patients were discussed at a multi-disciplinary (diabetic foot) team meeting following a day case algorithm. Patient and procedural characteristics, technical success, peri-procedural complications, and 30-day outcome of day-case angioplasties were compared with those requiring overnight stay or were hospitalized. Results: Fifty-seven percent of 138 patients were diabetic, mean age 75 ± 12 years, 95% had critical limb ischaemia (Fontaine III 12%, IV 83%), and baseline ankle brachial pressure index [ABPI] 0.40 ± 0.30. Sixty-three patients (45%) were treated as planned day cases, 21 (15%) required overnight admission for social indications. Fifteen (11%) were planned admissions with the need for sequential debridement procedures, and 39 (28%) were already hospitalised at the time of referral to the vascular service. The overall technical success was 92% and not successful procedures mainly occurred in patients > 80 years. The ABPI increased at the initial follow-up to 0.84 ± 0.18. Fifty-three percent required treatment of > 1 level, 80% included recanalisations of chronic total occlusions, and average total lesion length was 133 ± 90 mm. Closure devices were employed in all cases. There were no major peri-procedural complications. A single minor access-site related bleeding episode (0.8%) occurred, requiring 24 h observation in hospital. While significantly more wounds had closed in out-patients, the mortality, major amputation and target lesion revascularization did not differ between groups. Conclusions: Safe and effective day-case-based angioplasty can be provided in a secondary care setting for patients with critical limb ischaemia needing complex multi-level procedures.