bluuebunny/crossref_metadata_2025 huggingface dataset:
HYPERTENSIVE CRISES: EVOLUTION OF VIEWS, THERAPEUTIC TACTICS
Authors:   Grodno State Medical University, Grodno, Belarus, Pyrochkin V. M. , Mironchyk E. V. ,   Grodno State Medical University, Grodno, Belarus, Uskova I. V. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus, Khakalo Z. K. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus, Mituagina E. N. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus
Published: September 2024

Рatients with arterial hypertension have a high risk of cardiovascular complications, especially in patients with uncontrolled hypertension, the course of which is often accompanied by the development of hypertensive crises. The article resents the evolution of views on the classification of hypertensive crises and treatment depending on the complications that have developed.
HISTORY OF AMPUTATION PRACTICE IN CONNECTION WITH WARFARE. PART 2. ART OF AMPUTATIONS FROM THE END OF XVIII CENTURY TO MODERN TIMES
Authors:   Grodno State Medical University, Grodno, Belarus, Bakhta A. A. , Khilmonchyk N. E. ,   Grodno State Medical University, Grodno, Belarus
Published: September 2024

The beginning of the Industrial and French Revolutions has marked the radical hanges in the methods of warfare. The introduction of mass conscription and the continuous improvement of weapons during the following centuries had a significant impact on the structure and nature of combat injuries, and on the practice of limb amputations accordingly. At the same time, advances in medical technology and great discoveries such as antiseptics and antibiotics contributed considerably to the evolution of this surgical practice. This part of the article examines the development of the art of amputation in connection with warfare from the end of the XVIII century to the present day.
Determinan Pemilahan Sampah pada Pedagang di Pasar Rumbai Kota Pekanbaru
Authors: Khairatul Annisa  , Nila Puspita Sari  , Herlina Susmaneli
Published: September 2024

Pasar Rumbai belum melaksanakan kegiatan pemilahan sampah secara optimal. Sampah masih ditemukan berserakan di area sekitar tempat berjualan pedagang. Sampah yang tidak terkelola dengan baik dapat menimbulkan berbagai permasalahan seperti gangguan kesehatan, rusaknya estetika pasar serta pencemaran air, tanah dan udara. Tujuan penelitian untuk mengetahui determinan pemilahan sampah pada pedagang di Pasar Rumbai Kota Pekanbaru. Jenis penelitian analitik kuantitatif observasional dengan desain cross sectional. Analisis data dengan univariat dan bivariat (Chi-Square). Sampel berjumlah 131 orang dari 386 pedagang dengan menggunakan simple random sampling. Alat ukur dalam pengumpulan data adalah kuesioner dengan kurun waktu Mei-Juni 2022. Hasil penelitian menunjukkan terdapat hubungan antara Pendidikan (P-value = 0,000) POR = 3,980 (1,898-8,347), Pengetahuan (P-value = 0,000) POR = 5,048 (2,390-10,659), Sikap (P-value = 0,000) POR = 5,023 (2,367-10,656) dan Sarana (P-value = 0,000) POR = 4,295 (2,049-9,003) dengan pemilahan sampah pada pedagang di Pasar Rumbai Kota Pekanbaru. Disarankan Pasar Rumbai dapat meningkatkan fasilitas tempat penampungan sampah, memaksimalkan penyebaran informasi dan sistem pengangkutan sampah yang sistematis dan sesuai dengan jenisnya.
РАЗВИТИЕ СОЦИАЛЬНОЙ СФЕРЫ МУНИЦИПАЛЬНЫХ ОБРАЗОВАНИЙ РЕГИОНА НА ОСНОВЕ МЕЖСЕКТОРНОГО ВЗАИМОДЕЙСТВИЯ
Authors: Акимова Ю.А. , Грызлова А.В.
Published: September 2024

Вопросы социального развития имеют огромное значение при обеспечении его устойчивости. Особо остро данный вопрос стоит в отношении сельских территории. Следует отметить, что именно сельские территории занимают значительную часть всей территории нашей страны. Реформирование всей социально-экономической системы, периоды мировых кризисов, санкций и пандемия оказали значительное воздействие на многие показатели развития муниципальных образований. Разрабатываемые программы и проекты как для поддержки и обеспечения развития экономики, так и социальной сферы, несомненно, оказывают значимое действие. Однако при этом проблемы еще остаются. В проведенном исследовании авторами были проанализированы тенденции изменений основных показателей развития социальной сферы муниципалитетов Республики Мордовия; обоснованы направления развития социальной сферы муниципальных образований в регионе на основе межсекторного взаимодействия.
ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ РАЗВИТИЯ САНАТОРНО-КУРОРТНОЙ СФЕРЫ НА ВНУТРЕННЕМ И МЕЖДУНАРОДНОМ РЫНКАХ В УСЛОВИЯХ СОВРЕМЕННЫХ РИСКОВ ЗДОРОВЬЮ ЧЕЛОВЕКА
Authors: Брюханова Г.Д. , Воробей Е.К. , Городин В.Н.
Published: September 2024

Аннотация.   Неуклонный рост заболеваемости населения планеты неинфекционными болезнями (НИЗ) на рубеже веков и вплоть до 2019 г. был обусловлен патологией сердечно-сосудистой системы, хроническими болезнями органов дыхания, онкологическими болезнями, сахарным диабетом, болезнями нервной системы (включая психические расстройства).  Однако в 2019 г. произошло резкое обострение глобальной эпидемиологической обстановки с развитием пандемии коронавирусной инфекции COVID-19, которая привела к тяжёлым последствиям в социальной сфере, в мировой экономике, вызвала перенапряжение систем здравоохранения во всех странах мира не только в период её разгара, но и в настоящее время продолжает оказывать существенное негативное влияние на отдельные отрасли и секторы экономики (включая медицину) в связи со снижением качества человеческого потенциала, непосредственно связанным с постинфекционными осложнениями у лиц после перенесённого заболевания. Очевидно, что интересы развития государства в постковидный период времени потребовали переосмысления организационно-управленческих решений в системе здравоохранения, высветив важность проблемы реабилитации при НИЗ на рынке санаторно-курортных и рекреационных услуг. Цель исследования – анализ и прогноз неинфекционной заболеваемости в постковидный период времени в Российской Федерации в интересах сохранения качества человеческого потенциала с использованием современных медицинских технологий профилактики болезней и реабилитации. Выявлены причины, спектр, факторы риска и тренды формирования бремени НИЗ в мире и в Российской Федерации в современных условиях. Обоснована необходимость усиления и инновационной технологической трансформации санаторно-курортного звена в системе оказания медицинской помощи населению страны в условиях снижения качества человеческого потенциала. Определены актуальные направления подготовки медицинских кадров для санаторно-курортной сферы, сформулированы организационно-управленческие задачи совершенствования профилактики болезней и санаторно-курортной реабилитации в постгоспитальный период.
ФАКТОРНАЯ МОДЕЛЬ АНАЛИЗА СТОИМОСТИ БИЗНЕСА
Authors: Никифорова Н.А.
Published: September 2024

В статье рассмотрены принципы , а также факторы, формирующие стоимость бизнеса на примере авиакомпании. Под факторами внешней и внутренней среды подразумеваются переменные, влияющие на результативность ведения бизнеса. В качестве стоимости компании был осуществлен выбор в пользу величины рыночной капитализации. Данный выбор обоснован в первую очередь тем, что данный показатель публикуется в отчетности. Для расчетов и обоснования гипотезы автор исследовал факторы мега-, макро-, мезо- и микросреды авиабизнеса. Результаты проведенного исследования позволяют определить основные особенности учета влияния факторов внешней среды. Автор пришел к выводу, что он заключаются в структурированном подходе выявления факторов, а также в оценке влияния факторов на стоимость бизнеса.
ПОДХОДЫ К РЕАЛИЗАЦИИ РОЗНИЧНОЙ КРЕДИТНОЙ ПОЛИТИКИ ОТЕЧЕСТВЕННЫМИ КОММЕРЧЕСКИМИ БАНКАМИ
Authors: Меркулова Н.С. , Козлов И.С.
Published: September 2024

Эффективная кредитная политика, реализуемая коммерческим банком обеспечивает финансовую стабильность кредитной организации, что способствует достижению целей национальной политики, направленной на обеспечение экономического роста и повышение благосостояния граждан. Кредитование физических лиц в настоящее время является одной из наиболее востребованных и интенсивно развивающихся форм кредитования, служит средством удовлетворения потребностей населения за счет кредитных ресурсов, расширяет покупательские возможности граждан, увеличивает доходы банков, повышает экономический потенциал страны. Однако, в настоящее время в банковском секторе РФ наблюдаются тенденции роста просроченной задолженности в сегменте кредитования физических лиц, усиливается кредитная нагрузка населения, что также является фактором нарастания проблемной задолженности, кредитных рисов и, в конечном итоге, уровня доходности кредитных организаций.
ИННОВАЦИОННЫЙ ТИП ИНТЕНСИФИКАЦИИ ТРУДОВЫХ РЕСУРСОВ КАК МЕХАНИЗМ ЭФФЕКТИВНОГО УПРАВЛЕНИЯ НА РОССИЙСКИХ ПРЕДПРИЯТИЯХ ПИЩЕВОЙ ОТРАСЛИ
Authors: Козловская О.В.
Published: September 2024

Инновационный подход к интенсификации трудовых ресурсов, как эффективное использование человеческого капитала для освоения и реализации современных инновационных технологий и цифровых решений, находится в основе инновационного развития отечественных предприятий и агрокомпаний пищевой промышленности, что является особо актуальным и стратегически важным в настоящее время для национальной продовольственной безопасности Российской Федерации. Целью проведенного исследования является анализ подходов, аспектов и категорирования в современной экономической литературе интенсификации трудовых ресурсов как инновационного механизма управления действующих отраслевых российских предприятий пищевой промышленности страны. Автор в своем исследовании рассмотрел традиционный и инновационный подходы и характеристики направлений применения интенсификации трудовых ресурсов в современных отечественных предприятиях пищевой отрасли страны. Методология авторского исследования опирается на общенаучные методы анализа и синтеза, а также статистические и эконометрические методы изучения. Рассмотренный автором инновационный тип интенсификации трудовых ресурсов представляет собой уникальный современный инструмент для инновационного управления, в основе которого человеческий ресурс выступает главным драйвером и незаменимым ресурсом в инновационном развитии производственной системы отраслевого хозяйствования национальной экономики страны.
ОБОРОТНЫЙ КАПИТАЛ: СУЩНОСТЬ, УПРАВЛЕНИЕ И НОРМИРОВАНИЕ
Authors: Папалашев А.А.
Published: September 2024

Управление оборотным капиталом в современных условиях функционирования предприятий становится вектором роста его конкурентных преимуществ на рынке. Причиной тому снижение производственных затрат и потребностей в финансировании. Понимание сущности оборотного капитала необходимо для построения и эффективного управления им. Понятие оборотный капитала исследовано в экономической науке многими авторами. Вопросы определения сущности оборотного капитала в современной экономике сегодня актуализированы исходя из политической и экономической ситуации на мировом и российских рынках и для практической реализации механизма эффективного управления оборотным капиталом. Понятие оборотный капитал включает две основополагающих составляющих – капитал и оборотный. Оборотный капитал выступает, прежде всего, как стоимостная категория. Он не в буквальном смысле представляет собой стоимость в денежной форме, превращающийся в производственные запасы, незавершенное производство, готовую продукцию уже в процессе кругооборота. Разность между товарно-материальными ценностями и оборотным капиталом в том, что он не пускается в расход, не затрачивается, не потребляется. Оборотный капитал авансируется, переходя от одного кругооборота к следующему.
ИНВЕСТИЦИОННЫЕ ТЕНДЕНЦИИ И ПЕРСПЕКТИВЫ
Authors: Малиновская И.Н. , Рудых А.С.
Published: September 2024

В статье рассматривается влияние глобальных потоков прямых иностранных инвестиций (ПИИ) на мировую экономику в условии пандемии COVID-19. В статье рассматриваются инвестиционные приоритеты на этапе восстановления. Также рассмотрены конкретные проблемы, которые будут возникать в связи с внедрением инвестиционных планов восстановления, и предлагаются рамки политических действий для их решения. В рамках политики представлены инновационные действия и инструменты для определения стратегических приоритетов. Для директивных органов отправной точкой является стратегическая перспектива в форме подходов к промышленному развитию.
«ЗЕЛЕНЫЕ» ФИНАНСЫ ДЛЯ УСТОЙЧИВОГО РАЗВИТИЯ: НОВЫЕ ВЫЗОВЫ СОВРЕМЕННОГО ЭТАПА
Authors: Чернобай О.С. , Андреева О.В. , Сонина А.О.
Published: September 2024

В статье рассматривается тема, актуальность которой возрастает в силу необходимости уточнения положений концепции «зеленой» экономики в новых геополитических и экономических условиях санкционного и контрсанкционного давления, – использование «зеленого» финансирования для достижения устойчивого развития. В основе исследования лежат теоретические подходы концепции «зеленой» экономики, отраженные в научных работах по тематике «зеленой» экономики, «зеленого» финансирования, обосновывающие необходимость и возможности применения новых финансовых инструментов в контексте устойчивого развития. Рассмотрены практики «зеленого» финансирования, проанализированы причины, под действием которых изменяются прежние подходы к финансированию, администрированию и регулированию деятельности, связанной с озеленением экономики в России, среди которых особенно ярко проявляются снижение объемов и инструментов финансирования, дефицит иностранного оборудования и его компонентов, зависимость от технического обслуживания, снижение значимости экологической повестки, предложения по ослаблению административного влияния в системе защиты окружающей среды.
Structural and mechatronic aspects of improving the pipeline cleaning pig for creating a heat-insulating layer of wax deposits
Authors: Хасанов И.И. , Шакиров Р.А.
Published: September 2024

На протяжении последних десятилетий одной из ключевых проблем эксплуатации магистральных нефтепроводов является образование асфальтосмолопарафиновых отложений (АСПО) и их оседание на внутренней стенке трубопроводов при перекачке высокопарафинистой нефти. Данный процесс характерен как для новых месторождений, расположенных в Западной Сибири, так и для находящихся на III стадии разработки месторождений с высокой степенью разведанности и постепенно снижающимся объемом добываемой нефти и ее качеством. Процесс парафинизации труб является негативным фактором как для процессов транспорта нефти, так и последующей диагностики магистральных нефтепроводов, снижая надежность нефтетранспортной системы. На сегодняшний день на практике борьба с АСПО осуществляется по двум направлениям: удаление сформировавшихся отложений путем пропуска внутритрубных очистных устройств и предотвращение их образования путем применения соответствующих ингибиторов. По результатам исследований, проведенных рядом ученых, в том числе авторами статьи, была рассмотрена и подтверждена экономическая обоснованность идеи об эффективности использования формируемого слоя АСПО на внутренней стенке трубопровода как дополнительного внутреннего теплоизоляционного слоя. На данный момент в промышленной эксплуатации отсутствует устройство, конструктив которого позволяет сформировать равномерный слой АСПО.

Over the last decades one of the key problems of operation of trunk oil pipelines is formation of wax desposits and their deposition on the inner wall of pipelines during pumping of highly paraffinic oil. This process is characteristic both for new fields located in Western Siberia and for fields at the III stage of development with a high degree of exploration and gradually decreasing oil production volume and quality. Paraffinisation of pipes is a negative factor both for oil transportation processes and subsequent diagnostics of main oil pipelines, reducing the reliability of the oil transportation system. Nowadays in practice the struggle against wax deposits is carried out in two directions: removal of formed deposits by means of in-pipe cleaning devices and prevention of their formation by means of application of appropriate inhibitors. According to the results of researches conducted by a number of scientists, including the authors of the article, the economic feasibility of the idea about the efficiency of using the formed wax deposits layer on the inner wall of the pipeline as an additional internal thermal insulation layer was considered and confirmed. At the moment, there is no device in industrial operation whose design allows the formation of a uniform layer of paraffin deposits.
Pengenalan Setengah Wajah menggunakan Arsitektur Xception pada Metode Convolutional Neural Network
Authors: Subeki Fajar , Eliyani Eliyani
Published: September 2024

Penggunaan teknologi pengenalan wajah merupakan cara untuk mengidentifikasi seseorang berdasarkan ciri-ciri wajah. Penelitian ini berfokus pada pengenalan setengah wajah bagian atas dalam kondisi dimana hanya setengah wajah tersebut yang dapat diakses atau terlihat. Menggunakan metode yang melibatkan arsitektur Xception pada Convolutional Neural Network (CNN) untuk mengekstraksi fitur kompleks dari setengah wajah, termasuk dahi, alis dan mata. Data yang digunakan berasal dari absensi karyawan, termasuk 1020 dataset wajah tidak menggunakan masker dan 114 dataset wajah yang menggunakan masker. Penelitan ini menggunakan skenario pembagian data latih dan data uji dengan rasio 95:5, 90:10, 85:15, dan 80:20. Hasil penelitian menunjukkan nilai accuracy, precission, recall, dan f1-score terbaik terdapat pada pembagian data 95:15 yang masing-masing bernilai 95%, 96%, 96%, dan 95%. Hasil ini dapat digunakan untuk kontribusi pengembangan model pengenalan wajah dengan akurasi yang tinggi terutama dalam situasi di mana hanya informasi sebagian wajah yang dapat diakses.
Evaluation of Anti-Alzheimer’s Potential of Azo-Stilbene-Thioflavin-T derived Multifunctional Molecules: Synthesis, Metal and Abeta Species Binding and Cholinesterase Activity
Authors: Rana Monika , Terpstra Karna , Gutierrez Citlali , Xu Kerui , Arya Hemant , Bhatt Tarun K , Mirica Liviu M , Sharma Anuj Kumar
Published: September 2024

Inhibition of amyloid β (Aβ) aggregation and cholinesterase activity are two major therapeutic targets for Alzheimer’s disease (AD). Multifunctional Molecules (MFMs) specifically designed to address other contributing factors, such as metal ion induced abnormalities, oxidative stress, toxic A aggregates etc. are very much required. Several multifunctional molecules have been developed using different molecular scaffolds. Reported herein is a new series of four MFMs based on ThT, Azo-stilbene and metal ion chelating pockets. The synthesis, characterization, and metal chelation ability for [Cu(II) and Zn(II)] are presented herein. Furthermore, we explored their multifunctionality w.r.t. to their (i) recognition of Aβ aggregates and monomeric form, (ii) utility in modulating the aggregation pathways of both metal-free and metal-bound amyloid-β, (iii) ex-vivo staining of amyloid plaques in 5xFAD mice brain sections, (iv) ability to scavenge free radicals and (v) ability to inhibit cholinesterase activity. Molecular docking studies were also performed with Aβ peptides and acetylcholinesterase enzyme to understand the observed inhibitory effect on activity. Overall, the studies presented here establish the multifunctional nature of these molecules and qualify them as promising candidates for furthermore investigation in the quest for finding Alzheimer’s disease treatment.
COCONUT 2.0: A comprehensive overhaul and curation of the collection of open natural products database
Authors: Nainala Venkata Chandrasekhar , Rajan Kohulan , Kanakam Sri Ram Sagar , Sharma Nisha , Weißenborn Viktor , Schaub Jonas , Steinbeck Christoph
Published: September 2024

The COCONUT (COlleCtion of Open Natural prodUcTs) database was launched in 2021 as an aggregation of openly available natural product datasets and has been one of the biggest open natural product databases since. Apart from the chemical structures of natural products, COCONUT contains information about names and synonyms, species, and organism parts in which the natural product has been found, geographic information about where the respective sample has been collected, and literature references testifying all of this information. COCONUT is openly accessible at https://coconut.naturalproducts.net. Users can search textual information and perform structure, substructure, and similarity searches. The data in COCONUT is available for bulk download as SDF, CSV, and a database dump. The web application for accessing the data is open-source. Here, we describe COCONUT 2.0, for which the web application has been completely rewritten, and the data has been newly assembled and extensively curated. New features include data submissions by users and community curation facilitated in various ways.
Organo-electrocatalyst realizing efficient hydrogen production
Authors: Yang Jiarui , Li Wen-hao , Wang Dingsheng , Li Yadong
Published: September 2024

Hydrogen is not only a green fuel but also a source of life at the beginning of the universe. Till now, electro-catalyzed hydrogen production plays an essential role in high-purity hydrogen production, where platinum-based catalysts take up the main parts due to their high efficiency and durability. However, the limited resources and high costs of noble metal species prohibit its larger-scale application, making it necessary to put forward new alternatives. The organocatalysts thus show promising potential in the practical industry, which is easy to design and synthesize. More importantly, it doesn’t contain any metal, cutting down the costs. In this work, the organocatalysts containing nitrogen and phosphorus sites are designed, exhibiting high catalytic activity (19 mV@10 mA·cm-2, 143 mV@400 mA·cm-2) and stability (more than 60 days) in hydrogen evolution reaction (HER). With organocatalysts firstly applied in practical hydrogen production, the price of H2 per Nm3 (0.37 $ꞏNm-3) is reduced to half of the Pt-based catalysts, making it possible for society to step into the green-H2 era. Moreover, since organocatalysts are introduced into inorganic electrochemistry, a field of organ-electrocatalysis will arise, bringing evolution in metal-dominated cathodic electrocatalysis and traditional organic catalysis as well.
Association of Hemogram Parameters with Body Mass Index in Knee Osteoarthritis
Authors: Gundogdu Koksal , Gündoğdu Gülşah , Kurtoğlu Alper
Published: September 2024

Objective: This study aims to investigate the relationship between hemogram parameters, which are low-cost, easy, routinely applied low-grade inflammation indicators, and severity of knee osteoarthritis (KOA) and obesity.
Materials and Methods: This study involved 140 KOA patients aged 45 to 85 who underwent knee radiographs, weight and height measurements, and routine laboratory tests. Recorded data included demographic information (gender, age), body mass index (BMI), routine hemogram, and laboratory parameters. Patients were categorized into two groups based on their Kellgren-Lawrence (KL) scores (mild: KL 1-3, severe: KL 4) and four groups according to their BMI (BMI 35).
Results: The findings revealed significantly elevated levels of serum Neutrophil-to-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in severe KOA compared to mild KOA (P30 in mild KOA groups, while mean blood NLR was notably higher in patients with BMI=30-35 in severe KOA groups.
Conclusions: These results suggest that NLR and NMR could provide a new perspective on the relationship between obesity and mild KOA in clinical practice, presenting a cost-effective and easily applicable alternative for determining disease prognosis and progression.
Diagnostic Value of Neutrophil/Lymphocyte Ratio in Distinguishing Peripheral and Central Vertigo in Patients with Dizziness
Authors: Sertbaş İskender , Çiçek Mustafa , Yadigaroğlu Metin , Paslı Sinan , Yeniocak Selman , Gündüz Abdulkadir
Published: September 2024

Objective: Neutrophil/lymphocyte ratio (NLR) is an inexpensive parameter that gives an idea about systemic inflammatory response and cellular immune response. This study aims to investigate the value of NLR in distinguishing peripheral and central vertigo.
Materials and Methods: Patients presenting with acute vertigo at the emergency clinic were included between January 2017 and December 2018. Hemogram, brain computerized tomography, and diffusion magnetic resonance imaging data were reviewed to categorize patients into peripheral and central vertigo groups. Laboratory parameters were compared between these groups.
Results: Neutrophil, lymphocyte, and C-reactive protein levels were higher in patients with central vertigo than those with peripheral vertigo (p=0.003, p=0.003, p=0.022, respectively). Moreover, the NLR value was significantly elevated in central vertigo cases (median: 3.99) in contrast to peripheral vertigo cases (median: 2.32) (p
Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b
Authors: Vukovic Ivana , Barnada Samantha M , Ruffin Jonathan W , Karlin Jon , Lokareddy Ravi Kumar , Cingolani Gino , McMahon Steven B
Published: September 2024

Eukaryotic gene expression is regulated at the transcriptional and post-transcriptional levels, with disruption of regulation contributing significantly to human diseases. The 5′ m7G mRNA cap is a central node in post-transcriptional regulation, participating in both mRNA stabilization and translation efficiency. In mammals, DCP1a and DCP1b are paralogous cofactor proteins of the mRNA cap hydrolase DCP2. As lower eukaryotes have a single DCP1 cofactor, the functional advantages gained by this evolutionary divergence remain unclear. We report the first functional dissection of DCP1a and DCP1b, demonstrating that they are non-redundant cofactors of DCP2 with unique roles in decapping complex integrity and specificity. DCP1a is essential for decapping complex assembly and interactions between the decapping complex and mRNA cap-binding proteins. DCP1b is essential for decapping complex interactions with protein degradation and translational machinery. DCP1a and DCP1b impact the turnover of distinct mRNAs. The observation that different ontological groups of mRNA molecules are regulated by DCP1a and DCP1b, along with their non-redundant roles in decapping complex integrity, provides the first evidence that these paralogs have qualitatively distinct functions.
The geotourism industry in the 21st century: the origin, principles, and futuristic approach (2020)
Authors: Baptista Leandro , Geovan dos Reis Diego
Published: September 2024

Resenha
MÉTODO DE AVALIAÇÃO DA PERCEPÇÃO AMBIENTAL EM UMA SITUAÇÃO DE EMERGÊNCIA COM AUXÍLIO DA REALIDADE VIRTUAL E DE BIOFEEDBACK
Authors: Brombilla Douglas de Castro , Souza João Carlos
Published: September 2024

Objetivo: Construir um método para avaliar a percepção ambiental individual em uma situação de emergência, priorizando a percepção arquitetônica e, com isso, avaliar sua contribuição no processo de orientação.
 
Referencial Teórico: Foi realizada uma revisão da literatura sobre os seguintes temas: comportamento humano, simulação computacional, Realidade Virtual (VR) e biofeedback.
 
Método: Criou-se um ambiente virtual com oito pontos de decisão, cada um explorando diferentes atributos arquitetônicos. Para mensurar o nível de estresse, utilizou-se um equipamento de biofeedback para captar a variação da frequência cardíaca (VFC). Para a coleta de dados, aplicou-se uma entrevista semiestruturada, a fim de determinar o nível de consciência (NC) e a visualização dos atributos arquitetônicos (VAA).
 
Resultados e Discussão: O método mostrou-se eficiente, pois foi possível determinar se os participantes estavam transmitindo uma percepção real. Independentemente do estado de coerência cardíaca, o Nível de Consciência (NC) e a Visualização dos Atributos Arquitetônicos (VAA) apresentaram pontos percentuais próximos. Isso demonstra que a falta de coerência cardíaca impactou na visualização dos atributos arquitetônicos e, consequentemente, no nível de consciência.
 
Implicações da Pesquisa: O estudo tem relevância no campo da evacuação emergencial e nas simulações computacionais. O método foi aplicado em uma instituição de ensino, e suas implicações são significativas, mas deve ser ampliado para outros setores e públicos.
 
Originalidade/Valor: Este estudo contribui para a literatura por envolver a criação de um ambiente virtual diferenciado, que apresenta sempre a mesma tomada de decisão, independentemente das decisões anteriores. A relevância do estudo reside na influência da percepção arquitetônica em situações de emergência.
The Impact of Implementing School Zoning Policy on Inequality of Access to Education at the Junior High School Level
Authors: Susanto Ratnawati , Judijanto Loso , Irsyad Irsyad , Fitri Sri Adella
Published: September 2024

The Indonesian government has implemented a school zoning policy to address the gap in access for students from poor economic backgrounds. However, in reality, the implementation of the policy has not made it easier for students from poor economic backgrounds. There is a need for this study because there is a gap between theory, expectations, and reality in the field. The purpose of the study was to analyze the impact of the school zoning policy on access for students from poor economic backgrounds to junior high schools. The research method used was a mixed method. The subjects of the study were junior high school students with a population of nine regions totaling 5,000 students from poor economic backgrounds and a sample of 850. Data collection techniques used surveys, observations, interviews, and documentation. Survey analysis techniques with descriptive statistics using SPSS Version 25.0 by assessing the mean, percentage, and standard deviation. Qualitative data analysis reduced the data and allowed the researchers to draw conclusions by comparing it with the results of quantitative data. The results of the study were that the school zoning policy in Indonesia is effective in reducing the gap in access for students from poor economic backgrounds in public junior high schools so that the distribution of students between schools becomes more even. However, there was a negative impact on some students from poor economic backgrounds if zoning access was limited. In conclusion, the school zoning policy can distribute students evenly between schools but most poor students cannot access public schools. Recommendations are made for research to be conducted by involving the government in a broader study.
ABOUT SOME FEATURES OF THE POETIC LANGUAGE OF ELENA SCHWARTZ
Authors:   Russian State University for the Humanities, Pronin Maksim V.
Published: September 2024

The article analyses some features of the way Elena Sсhwarz, a representative of Leningrad uncensored poetry, used the means of poetic language. In her texts, most often written in compliance with all the norms of traditional syllabic tonics, she actively practiced form and word – creation, invented new words and sentences without a semantic layer, introduced foreign borrowings, ready-made quotes from other literary works and abusive language. In some cases, she could also conduct experiments with non-standard graphic presentation of text, trying to achieve ideal symmetry. Studying the uniqueness of the poetic idiolect (language means regularly repeated in texts, new verbal constructions, whole words or forms of words, syntactic constructions) of one of the “uncensored” Leningrad authors helps the reader to better understand how her artistic world was created.
THE PORTRAYAL OF SATAN IN JOHN MILTON’S “PARADISE LOST” AND PHILIP PULLMAN’S “HIS DARK MATERIALS” TRILOGY
Authors:   Moscow City University, Biserova Anna D.
Published: September 2024

This article provides a comparative analysis of the portrayal of Satan in John Milton’s epic poem “Paradise Lost” and Philip Pullman’s “His Dark Materials” trilogy, focusing on genetic and typological similarities. Drawing upon scholarly research and critical interpretations of the above works, it studies the multifaceted nature of Satan’s character. It also considers contrasting perspectives, thematic implications, and narrative strategies. The article analyzes narrative techniques and symbolic aspects related to the portrayal of Satan, highlighting the significance of these works in addressing moral and religious issues. The author contributes to a deeper understanding of the literary and philosophical aspects of tradition and innovation in the depiction of Satan, based on the analyzed literary works
ROLE OF INDIAN CONSTITUTION IN WOMEN EMPOWERMENT
Authors: Karadia Mamta , Mehta Sakshi
Published: September 2024

The Indian Constitution is a beautiful blend of both federal and unitary systems. The Indian Constitution is called a federal constitution on the basis that it is a written constitution. It provides for a supreme and independent judiciary. The preamble of the Indian Constitution declares the goal of making India a democratic republic. Its head of state will be elected democratically. Being a republic means that any common person of India, whether a man or a woman, can reach the highest position in the country on the basis of his qualifications. India is a union of states. It is an independent sovereign socialist democratic republic with a parliamentary system of government. This republic is governed according to the Constitution of India which was adopted by the Constituent Assembly on 26 November 1949 and which came into force on 26 January 1950. The Constitution of India is the supreme legal authority that links together the legislative, executive and judicial organs of the government. The Constitution provides fundamental rights to all citizens and gives the independent judiciary the right to declare invalid the laws or government actions that violate the Constitution. In the Vedic period, women had a very respectable position in India. But later in the medieval period, the status of women deteriorated a lot due to the arrival of foreigners. Due to illiteracy, bad customs and conservatism in the society, the status of women was greatly affected. But gradually in the first half of the nineteenth century, some social workers of India like Raja Ram Mahen Rai, Swami Dayanand Saraswati, Ishwarchand Vidyasagar and Keshavchand Sen raised their voice against the oppressive social system. They raised their voice before the then British rulers for gender equality, women education, ban on Sati Pratha and ban on polygamy, as a result of which Sati Pratha Prohibition Act, 1829 and Hindu Widow Remarriage Act in 1856, Age of Constancy Bill in 1891 and Vative Marriage Act to stop polygamy were passed. By the twenty-first century, the condition of women started improving and the Indian Constitution implemented provisions to promote women's upliftment and empowerment and to improve their economic, social, educational and political status and to include them in the mainstream of development by running many welfare schemes and developmental works.
BIOREGIONAL IDENTITY AND DISPLACEMENT: A STUDY OF HOME, MEMORY AND SPATIAL CONSCIOUSNESS IN 'A HOUSE FOR MR. BISWAS’
Authors: Dewangan Nandkumar , Khan A.A. , Talat Qamar
Published: September 2024

This paper examines V.S. Naipaul's 'A House for Mr. Biswas' through the lens of bioregionalism, focusing on the interplay between identity, displacement, and spatial consciousness. By analyzing the protagonist's quest for a home within the context of colonial Trinidad, this study explores how bioregional identity is shaped, challenged, and reimagined in the face of cultural and geographical displacement. The research employs close textual analysis and draws on theoretical frameworks from bioregional studies, postcolonial theory, and spatial theory to investigate the novel's portrayal of home, memory, and place-based identity. Findings suggest that Biswas's struggle for a house represents a broader search for bioregional belonging in a colonized space, highlighting the complex relationship between individual identity and place in postcolonial contexts. This paper contributes to the growing body of literature on bioregional approaches to postcolonial studies and offers new insights into Naipaul's seminal work.
Effect of Different Metals on Synthesis of Siderophores by Endophyte Bacteria Isolated from Various Annual Plants
Authors: Atbaş Şilan , Taşkın Bilgin
Published: September 2024

Endophyte bacteria are microorganisms that pass all or part of their life cycle in the tissues of healthy plants without causing any obvious signs of disease. Most siderophore-producing endophytic bacteria could improve the plant growth. Here, the effect of metals, iron (Fe), nickel (Ni), and cobalt (Co), on the growth and siderophore production profiles of 30 endophyte bacterial isolates were investigated. The results of the Minimum Inhibition Concentration (MIC) tests showed that endophytes exhibit varying degrees of tolerance to heavy metals and the metal tolerance decreased in the order Fe3+>Ni2+>Co2+. It was revealed that while 10 isolates could not produce siderophores under any circumstances, 20 isolates produced siderophores at different degrees, and siderophore molecules synthesized and secreted by these 20 isolates had affinities for all three metals (Fe3+, Co2+, and Ni2+). In addition, siderophore production profiles of isolates under each heavy metal stress were investigated by adding these metals to the Chromium Azurol Sulfonate (CAS) medium at optimum concentration. The results suggested that siderophore synthesis could be one of the coping mechanisms of only two isolates with Co2+ and Ni2+ heavy metals. In the final stage of the study, molecular identification of a certain number of isolates selected according to their siderophore production values was carried out by 16S rRNA sequencing. As a result of the sequence analysis, 2 Pseudomonas sp., 4 Bacillus sp., 1 Chryseobacterium sp., 1 Staphylococcus sp., and 1 Peribacillus sp. were revealed.
Micropropagation of Vaccinium corymbosum L.‘Bluecrop’ in Rocker Temporary Immersion System (TIS) Bioreactor
Authors: Sereda Mikhail
Published: September 2024

Blueberries are high-value fruits. The traditional method of propagation by cuttings cannot supply the modern market with large quantities of seedlings. The method of micropropagation of plants in vitro makes it possible to bring the production of blueberry seedlings to the highest level. Blueberries have not been sufficiently studied in in vitro culture, so the search for the simplest and most cost-effective methods of micropropagation remains relevant. The problem of accelerated micropropagation of blueberries can be solved using rocker-type bioreactors, which differ from other models in terms of simplicity of design and low cost. A study was carried out to evaluate the effectiveness of micropropagation of Vaccinium corymbosum 'Bluecrop' in rocker bioreactors. Two types of bioreactors were compared: the bioreactor of the Platform system and the TIS rocker bioreactor modified by the author. As a control, blueberries were grown on a semi-solid medium. The effectiveness of blueberry micropropagation was evaluated by the following indicators: multiplication coefficient, shoot length, and proportion of vitrified shoots. Experiments were conducted on WPM medium, with zeatin supplementation at a concentration of 1.0 mg/l, resulting in optimal results. It is shown that the rocker bioreactor is slightly inferior to the plantform bioreactor in micropropagation but outperforms the method of micropropagation on semisolid media. The rocker bioreactor can be fully utilized for production purposes. In order to reduce costs and increase technical reliability, the working principle of the mechanical drive of the author's model of a rocker-type bioreactor was changed.
PENINGKATAN MOTIVASI REMAJA SMPN 1 GENDING GUNA MENGURANGI NILAI PERNIKAHAN DINI
Authors: Maksin Mastina , Azzahra Putri Fatimattus , Nafsiyah Azizah Tun , Pratama Vegas Albar , Nuraliza Vadhea , Ningrum Erika Fara Septia , Nasution Hermawan
Published: September 2024

Teenagers are individuals between the ages of 12 and 18, and they are an important part of our society. Teenagers today face many challenges, including conflict problems and early marriage. Conflict can disrupt the learning process and make it difficult for students to concentrate and reach their full potential. Early marriage, on the other hand, can have broader negative consequences, including poorer health outcomes, lower employment opportunities, and lack of education. Early marriages that occur in Randupitu village are very high because many teenagers who marry are not yet old enough. This research uses the community service method with qualitative descriptive presentation. In order to clearly explain the implementation that has been carried out in the field. The research subject is the OSIS of SMPN 1 Gending which is located in Rondokuning, Randupitu, Gedning subdistrict, Probolinggo Regency. The implementation method is by holding outreach to provide motivation to students regarding the importance of education and early marriage by eliminating feelings of boredom in students. Providing motivation about the importance of education by eliminating feelings of boredom is an important achievement that can make it possible to minimize early marriage in Randupitu village. This activity emphasizes the importance of education for teenagers so they can plan a good future for their families and children. The OSIS of SMPN 1 Gending has recognized the role of teenagers in education by having principles and themselves in reducing feelings of excitement. The students know that these teenagers have a very important role in realizing the nation's ideals.
The Effect of Assessment for Learning in Chemistry Learning on Students' Learning Outcomes
Authors: Hasanah Sufa Adatul , Muchlis Muchlis
Published: September 2024

This research aims to describe the effect of the implementation of assessment for learning (AfL) in chemistry learning on student learning outcomes. This type of research is pre-experiment. The design used in this research is One Group Pretest Posttest Design, with the same treatment in class XI, that is pretest - meeting 1 - posttest 1 - meeting 2 - posttest 2. Meetings 1 and 2 respectively are the implementation of AfL on the material of acidic buffer solutions and basic buffer solutions. The subjects of this research were students of class A and B SMAN 2 Bangkalan. Students' chemistry learning outcomes were obtained from the results of pretest, posttest 1, and posttest 2. Data analysis techniques using normality test followed by hypothesis testing and N-Gain test. The results showed that there was a significant difference between the pretest and posttest 1 and between posttest 1 and posttest 2 in classes A and B. Students' learning outcomes also improved based on the results of the N-Gain test. Based on the results of the research, it can be concluded that the implementation of AfL in learning chemistry has an effect on learning outcomes and is able to improve student learning outcomes
Transmission Channel of Agriculture Food Import Tariff to Stunting Prevalence
Authors: Montolalu Maya Hendrietta , Timban Jean F.J. , Tangkere Ellen G.
Published: September 2024

Increases in food prices affect poverty in a way that poor consumer is harmed due to the high proportion of their budget they spent on food. Stunting prevalence might be instigated by several factors such as access to food and nutrition intake, genetic and environment. This research aims to analyse the effect of food import tariffs towards the stunting prevalence of children aged under 5 (five) across districts in Indonesia, and we explore the indirect relationship between stunting prevalence and trade policy. This research uses quantitative descriptive research methods, utilizing both primary and secondary data. Primary data were obtained through the distribution of questionnaires, followed by Focus Group. Secondary data were obtained from relevant institutions such as the Central Statistics Agency, research journals, and related books. The method of data analysis in the study uses quantitative analysis with a mathematical model. The results showed that tariffs can reduce the consumption of foods that serve in the intake of dietary nutrients such as calories, protein and fat. As a result, food intake affects the prevalence of stunting. Trade liberalisation can have a beneficial impact on child health. The effects of trade liberalisation on stunting through the food channel include: a) trade has a significant effect on calorie, protein, and fat intake, b) intake of these nutrients has a significant effect on child stunting.
Successive Operations with Real Variable Applied to Representing Special Functions and Computational Modeling
Authors:   , Moesia Marlo
Published: September 2024

Successive products were originally developed starting from successive operations applied on integer-indexed sequences and have been applied to solve recursive equations also indexed by integers. This thesis presents an extension of successive products from the integer to the real domain. This is performed by proposing a new recursive system of equations and establishing the methodology to solve them. This approach is applied to efficiently represent and compute known special functions, like gamma, factorial, and double factorials, among others. Moreover, beyond those special functions, other ones become representable by successive products. This technique can be an alternative for analysis and mathematical modeling.
Mesofractal Modeling of Biosystems & Organic Spintronics
Authors: Widastra Hidajatullah Maksoed
Published: September 2024

Mesoscopic modeling of complex systems involves thermodynamic nonequilibrium of discrete scaling. Further from quantum correlation on a chip retrieved quantum nonlinear optics with single photons enabled by strongly interacting atoms. Accompanied by mesofractals as the development of meso & micro size fractal structures is required to mimic various biological systems for various functions. Showed through fluorapatite in gelatin‐based nanocomposite, fractal in DNA knots driven by balance of fission & fusion in mtDNA/mitochondrial DNA mechanism, for optical engines for light energy detection described the proportional integral derivative [PI(D)]‐controller set in microbial cells to HCCI/Homogeneous Charge Compression Ignition.
Pergamos. An unexplored fortified site in north-eastern Greece
Authors: Klingborg Patrik , Galani Georgia , Blid Jesper , Dadaki Stavroula , Malama Penelope
Published: September 2024

The aim of this article is to present the first results of a project investigating the hitherto unexplored site of Pergamos, located on a hill known as Koules/Alonaki just to the south of modern Moustheni in the Pieria valley. The site has a long history, with the earliest traces of human activity dating to the Late Bronze Age and the first visible architectural remains—impressive and well-preserved fortifications built in a stack-work technique—originating in the Late Archaic period. Following this, surface finds testify to activity and habitation throughout the centuries until a substantial strengthening of the defensive walls during Late Roman or medieval times, before the site was abandoned at a currently unknown point. To achieve the aim the article begins with an introduction to the site and its surrounding landscape. Following this, the results of a survey of the visible remains are presented, focusing on the fortifications and two architectural fragments. The site is then discussed within its spatial and chronological context, suggesting that Pergamos was an important settlement in the area, exhibiting traits of a polis, in particular during Archaic and Classical times before it fell within the sphere of influence of the Roman colony Philippi.
Architectural terracottas from San Giovenale. Addenda and conclusions
Authors: Wikander Örjan
Published: September 2024

The publication of most excavation areas at San Giovenale has made it possible to offer a much more detailed and more accurate account of the use of architectural terracottas at the site. This article presents the finds according to categories and types as well as according to their distribution in different excavation areas. It also discusses technical matters and chronological issues. A survey of all decorative terracottas discovered at the site shows that these were not as rare as earlier believed. The conclusion tries to sketch the development of the local terracotta industry.