bluuebunny/crossref_metadata_2025 huggingface dataset:
Is There a Bilingual Advantage in Executive Functions in Healthy Adults? A Systematic Review
Authors: Sun Xue
Published: February 2023

Research on the benefits of bilingualism for executive functions has produced conflicting findings. This review systematically summarizes the findings of 27 studies from 23 articles on this topic from the last decade, with participants’ ages ranging from 18 to 60. We extracted data on participants’ backgrounds and the results of different task paradigms. We found no significant bilingual advantage in executive functions in healthy adults between 18 and 60 years of age, although the conflicting results make it challenging to draw a decisive conclusion.
A clinical profile of sputum positive pulmonary tuberculosis among elderly patients
Authors: Ambali Anand Premanand , Tomar Priyanka , Pranay Kumar R P
Published: February 2023

The Pulmonary Tuberculosis has been known to mankind to cause increased morbidity and mortality especially in elderly. There is delay in diagnosis of pulmonary tuberculosis which led to increased mortality. Hence, this study looks into the pattern of presentations of the pulmonary tuberculosis and the radiological features that these patients demonstrate, which may help in early diagnosis and effective management.

A cross-sectional, descriptive study was conducted on seventy patients above 60 years of age, who attended the outpatient department or those who were admitted in the geriatric ward of BLDE DU, Shri B. M. Patil Medical College, Hospital and Research Centre with symptoms suggestive of pulmonary tuberculosis over a period of twenty-four months irrespective of sex. The patients who tested sputum positive by ZN Stain for Mycobacterium Tuberculosis irrespective of primary diagnosis, defaulters and reactivation of pulmonary tuberculosis were included in the study group.

In our study male predominance was seen with 48% of elderly in age group of 60-65 years. Majority (67%) of patients had typical features like fever, cough, evening rise of temperature while 32% had atypical symptoms like decreased appetite, increased thirst, weight loss and breathlessness. The common comorbid was Hypertension (10%). The most common radiological feature was miliary mottling (21%), while there was 11% mortality reported.

This study being carried on elderly with sputum positive have given insight on the various pattern of clinical presentations and radiological features in elderly. Importance of sputum examination cannot be undermined in elderly and high degree of suspicion will help reach the diagnosis.
A coragem e o profetismo de Bento XV: um necessário resgate histórico
Authors: de Souza Ney , da Silva Dias Tiago Cosmo
Published: February 2023

O artigo pretende expor a ousadia e, ao mesmo tempo, a coragem evangélica do papa Bento XV, que governou a Igreja de 1914 a 1922, no período da Primeira Guerra Mundial, para a qual o pontífice lançou diversas críticas e exortações de paz aos beligerantes, ainda que sem sucesso. Por meio de averiguação bibliográfica em autores da história eclesiástica, faz-se um breve relato do contexto histórico em que Bento XV foi eleito, com ênfase na Primeira Guerra Mundial, para se destacar sua atuação diante do conflito. Ao mesmo tempo, destaca-se sua firmeza na redação da Carta Apostólica Maximum Illud, no contexto das atividades missionárias, que também acabou por desagradar algumas alas da Igreja pela sua firme postura ao dizer, por exemplo, que congregação alguma é dona de determinado território, mas deve ali se instalar até que se forme um clero local. Analisando a conduta de Bento XV diante de ambas as situações, constata-se que foi um papa que sempre soube dizer a verdade e não se preocupou com a popularidade, razão pela qual acabou por se tornar uma personagem esquecida ou pouco explorada. Nesse sentido, este texto também procura resgatar a incansável atuação de Bento XV e saudá-la, trazendo-o para o rol de um dos importantes pontificados do século XX.
Repensar el fenómeno religioso. Aproximación al encuentro entre la mística y la posibilidad de ser
Authors: Valencia Castañeda Diego Fernando
Published: February 2023

El sentido de la vida se encuentra más allá de conceptos escatológicos que, en ocasiones, apartan al ser humano de su constitución como proyecto. Este sentido puede estar fundado, desde una perspectiva heideggeriana, en el “hecho” de ser-en-el-mundo. Esta concepción da lugar a la necesidad de comprender mejor el fenómeno de la vida religiosa en tanto manifestación de la búsqueda de sentido que sigue interpelando al humano que retorna al fenómeno religioso que procura una respuesta ante su búsqueda por el sentido de la vida y del hecho de que tal búsqueda remite al misterio mismo de existir. El ser humano del fenómeno religioso no está exento de la tentatio, considerada por el cristianismo primitivo como una dispersión. Dicha tentatio, sin embargo, podría ser un elemento de gran valor en la vida, en la medida que lograra conducir al ser humano a un sentido: la reflexión ante el misterio mismo de vivir. En este contexto surgen interrogantes como: ¿En qué medida la filosofía puede aportar para repensar el fenómeno religioso? ¿Cómo se ha leído y cómo debería leerse el fenómeno de la vida religiosa? ¿Por qué volver la mirada a este fenómeno en el mundo de hoy? Este artículo tomará como referencia principal la Fenomenología de la vida religiosa, de Heidegger, obra a partir de la que se podrían comprender mejor algunos conceptos del cristianismo primitivo para una reflexión y comprensión tal que el lector logre analizar el sentido de la vida religiosa más allá de las instituciones en una perspectiva fundamentalmente mística.
Empreendedorismo imigrante de mulheres brasileiras em Toronto, Canadá
Authors: Mott Machado Michel , Cruz Eduardo Picanço , Pessoa de Queiroz Falcão Roberto
Published: February 2023

Objetivo: Este artigo teve como objetivo analisar o perfil sociodemográfico e empreendedor de mulheres brasileiras imigrantes em Toronto, no Canadá, bem como características dos negócios em si. Método: Os dados foram coletados em Toronto por meio da aplicação de questionários com 47 mulheres empreendedoras brasileiras e 22 entrevistas semiestruturadas, representando uma abordagem multimétodos. A análise incluiu estatísticas descritivas e análise qualitativa das trajetórias e histórias de vida. Principais Resultados: As respondentes são majoritariamente da Região Sudeste brasileira, branca, casada, com filhos e idades entre 30 e 59 anos, alto nível de escolaridade e de proficiência em inglês. A maioria dos negócios é de pequeno porte/individual, do setor de prestação de serviços. O mercado-alvo, em sua maior parte, é de brasileiros/as residentes no Canadá, portanto, étnicos e coétnicos. A importância de networking às atividades empreendedoras é amplamente reconhecida. Pontuou-se dificuldade relacionada ao balanceamento trabalho-família, o que requer aprofundamento em estudos futuros sobre a influência de recursos familiares e dos papéis de gênero nos caminhos do empreendedorismo de mulheres imigrantes brasileiras no Canadá. O trabalho ainda destaca a interseccionalidade da inserção de empreendedoras imigrantes brasileiras na sociedade canadense. Relevância / Originalidade: O trabalho enfoca um público pouco pesquisado, o de empreendedoras brasileiras no Canadá, evidenciando elementos importantes de sua atuação no país. Contribuições Teóricas / Metodológicas: O artigo contribui para a literatura do empreendedorismo feminino no Canadá.
Here is the metastasis - find the primary carcinoma for it: a large biopsy study
Authors: ÖZDEMİR Çiğdem , ŞENOL Yiğit , BAYKARA Meltem , AK Mehmet Olgun , DEMİR Hacer , SARIKAYA Yasin
Published: February 2023

Objectives: According to estimates, cancer of unknown primary origin (CUP) accounts for approximately 3 to 5% of new cancer cases annually in the United States. With early diagnosis, many CUP patients can achieve long-term remission. The aim of this study was to document the organ tropism for metastasis for tumors with a definite primary cancer. In addition, we sought to contribute to understanding organ tropism in tumors of unknown origin.
Methods: Retrospectively, biopsies of 492 metastatic cancers were evaluated. The required immunohistochemical panel was applied to determine the tumors’ origins.
Results: A total of 492 patients with metastases were included in the study. The most common origins of metastasizing tumors were lung (25.4%), colon (18.9%), breast (15.4%) and stomach cancers (10.6%). The least metastatic tumors were the salivary gland, neuroendocrine, adrenal, tubal, nasopharynx, rectum and esophagus cancers (0.22% for all). The most common cancers that metastasized to the liver were colon cancer (29.0%), stomach cancer (18.6%) and pancreatic cancer (18.6%). The most common cancers that metastasized to the bone were lung cancer (58.0%), breast cancer (29.0%), and prostate cancer (13.9%). The most common types of tumors that metastasized to the lungs, the kidney (35.1%), colon (29.7%), and breast cancers (16.2%), were the most common. The most common tumors that metastasized to the brain were the lung (61.1%), the breast (16.7%), and kidney cancers (8.7%). The most common tumors metastasizing to the skin were lung (31.0%), breast (27.6%), and colon (13.8%) cancers.
Conclusions: Primary cancers have different metastatic patterns, which may help determine their causes. By involving distant anatomical structures and disrupting their function, tumor metastases increase the morbidity and mortality associated with the disease; thus, they affect staging, prognosis, and treatment. Metastases (or cancers from unknown primary sites) usually require extensive investigation to determine their primary source. Whether the cancer is tracked prospectively or retrospectively, a detailed observational template highlighting expected metastatic patterns would greatly assist in diagnosis and treatment.
Prevalence and Virulence Characterization of Staphylococcus aureus Isolates from Chicken Meat and Ready to Eat Chicken Products to Assess Hygiene and Consumer Safety
Authors: Thakur Vijaya Singh , Gupta Bhavana , Singh R.V. , Nayak Anju , Shukla Sanjay
Published: February 2023

Background: Meat and meat products are good source of proteins and essential amino acids for health. These products are contaminated with various pathogens like S. aureus, Salmonella spp, E coli and Listeria spp., S. aureus is one of most important food borne pathogen associated with food products. The present study was carried out to estimate prevalence of S. aureus and their molecular characterization in raw chicken meat and ready-to-eat chicken products in Jabalpur city. Methods: The samples were collected from different retails outlets and processed as per standard microbiological procedures for isolation of S. aureus and subjected further for molecular characterization and processed to assess the prevalence of S. aureus. A total of 100 raw chicken meat and 70 ready to eat chicken meat products (chicken samosa, momos, pattis, tikka, barbeque etc.) have been collected. Result: The overall prevalence of S. aureus was observed 38.82% with 38.00% in raw chicken meat and 40.00% in ready-to-eat chicken (RTE) products. The molecular study revealed that all the S. aureus isolates were positive for 16s ribosomal RNA (rRNA). Out of 66 isolates, 27 (71.05%) from raw chicken meat and 12 (42.85%) from ready to eat chicken meat products isolates were found to be positive for sea gene where as 3 (7.8%) isolates from raw chicken meat and 6 (21.42%) from ready-to-eat chicken products were found positive for nuc gene respectively.
The Effect of Storage Periods on the Internal and External Quality Characteristics of White and Brown-Shell Table Eggs in Saudi Arabia
Authors: Murshed Mutee , Qaid Mohammed M. , Gatasheh Mansour K.
Published: February 2023

Background: The eggs of hens are an essential source of protein, a food that meets human needs and provides the body with amino acids, metallic elements and vitamins that promote its health. The research aims to study the influence of storage period and strain and the interaction between them on components and internal and external quality traits of commercially produced brown and white-shell eggs. Methods: A total of 180 eggs were randomly collected from both types. It was kept for 0, 15 and 30 days at temperatures ranging from 5±2°C to a humidity level of 60%. All eggs were broken to measure the egg coefficient, egg weight, egg weight loss and depth of the air chamber. shell thickness, shell density, shell cleanliness, shell surface area, shell weight relative to shell area unit, egg specific density, Haugh unit values, yolk color, presence of flesh and blood spots, white weight, shell weight, yolk weight, shell integrity, white weight percentage, percentage of shell weight, yolk weight ratio and yolk weight ratio. Result: White eggs weighed more than brown eggs and storage periods had a significant (P less than 0.05) effect on the Haugh unit, specific density, air chamber depth and shell thickness. It has a positive effect on shell density and shell weight for both brown and white-shelled eggs. The storage period also led to a significant increase in weight loss, a significant decrease in white, yolk and shell and significant changes in all parts of the egg because the shell color changed.
Development and psychometric testing of blended learning for nursing clinical practice
Authors: Sanongdej Wanna , Tantiprasoplap Sukanya
Published: February 2023

A Blended lesson evaluation is used to assess blended lessons preparing the nursing students for clinical practice. The objectives of this study were to develop a blended learning for nursing clinical practice (BNCP) instrument and test its psychometric properties. This study makes use of a mixed-method sequential explanatory design. Twenty-two items were developed from the review literature. The BNCP instrument was examined by five experts in terms of content validity. A quantitative study was conducted using exploratory factor analysis and confirmatory factor analysis (CFA). The sample consisted of 220 nursing students. The results showed that BNCP was composed of three factors, namely the learning process, convenience in terms of learning and ability to perform. The indicators had a range of communality, i.e., from 0.274 to 0.752. Three factors accounted for 60.29% of the variance. The remaining 16 items were analysed by CFA in secondary order in another group. The measurement model fitted the empirical data (p > 0.05). The most important indicator revealed by the BCNP model was ‘ability to perform’. Finally, the instrument retained 3 subscales of 15 items that had construct validity. BNCP has good construct validity and reliability. BNCP is a tool that can be used to assess the learning of nursing students.
Keywords: Blended learning; nursing clinical practice tool; psychometric test
dimensión artística en la revista intelectual Pasado y Presente
Authors: Delupi Baal Ulises
Published: February 2023

En Argentina, en la segunda mitad del siglo XX, el fervor revolucionario ocupaba el centro del discurso intelectual. En ese marco, es posible detectar, en algunas de las publicaciones de la época, una recurrencia temática vinculada a los procedimientos estéticos y artísticos. El presente artículo se propone analizar el modo en que se construye el tópico artístico en el discurso intelectual de la revista Pasado y Presente , una de las publicaciones más resonantes de la historia de Argentina. Nos proponemos caracterizar al grupo intelectual para luego indagar, desde una perspectiva sociosemiótica, aquellos documentos que tratan cuestiones vinculadas al arte, sobre todo a la literatura. Los resultados de investigación muestran un marcado interés del grupo intelectual por el arte en los primeros números, asunto posibilitado por el estado de discurso social de los 1960 y 1970, y la posterior pérdida de esa tematización, sobre todo en el segundo momento de aparición de la revista.
The Effect of Poetry Reading Studies Based on Reading Strategies on Reading Fluent Skills
Authors: KESİK Cengiz , POLAT İlhan
Published: February 2023

The aim of this study; The aim of this study is to examine the effects of poetry reading activities based on repetitive reading, model reading and resonant reading strategies on primary school students' reading levels, reading speeds and reading errors. For this purpose, the research was designed according to the pre-test-post-test trial model, which is one of the semi-experimental designs. The study group of the research consists of 68 primary school first grade students determined according to the criterion sampling method. Error Analysis Inventory was used as a data collection tool in the research. Analyzes were made using descriptive statistics, dependent T-Test and Wilcoxon Signed Rank Test based on the number of misread words, percentage of correct reading and reading speed. According to the results of the analysis, it was determined that the number of wrong reading words of primary school first grade students who are at the education level decreased, and their reading level and speed increased. 55% of the students at the education level started to read at the free reading level. It was determined that the number of misreading words decreased and the reading level and speed increased in the first grade primary school students at the anxiety level. 30.40% of the students at the anxiety level started reading at the free reading level, and 47.82% at the education level. It was observed that there was a mathematical increase in the reading levels of the students with the remaining anxiety level.
Implementasi Bauran Pemasaran Pada Production House ZH Picture
Authors: Rivangga Kresna , Julianto Didik Eko , B.P Dwi Windradini
Published: February 2023

Service marketing is a marketing that cannot be seen but can be felt. Services must prioritize the convenience of service to consumers. Services cannot be returned like finished goods. The marketing mix is ​​a set of products, prices, places, promotions, processes, people and physical evidence. The marketing mix is ​​used to measure the level of marketing success and all of it is aimed at getting the response that consumers want. The marketing mix is ​​a tool used by sellers to shape the characteristics of the services offered to customers. Production house is a service business that is engaged in fields such as photo and video content creator, design, content writer, audio visual that has an organizational structure. Production houses provide displays of their productions to the general public either directly or broadcasting. Production House in managing motion or static information where information can be sourced from humans or existing events. ZH Picture is a Production House in Jember which is engaged in photo and video making services such as weddings, company profiles, and product advertisements. The level of success is measured by the company ZH Picture by using the marketing mix of goods and services and creating innovation.
Studies on the flame structure and drag of a combusting droplet group
Authors: Zhou Lixing , Li Ke , Sun Ting
Published: February 2023

Droplet combustion has been studied by experiments and numerical simulation for many years, and most of studies were done about single droplets. As for droplet groups, some theoretical and experimental studies were reported, but less of numerical studies. One of the important characteristics is the drag of combusting droplets, which is closely related to flame structure and is a sub-model in numerical simulation of spray combustion. There are contradictory research results for the drag of combusting droplets. In the present paper, large-eddy simulation (LES) is used to study the flame structure and drag of a combusting ethanol-droplet group. The results show that there are three combustion modes: fully-enveloped flame, partially-enveloped flame and wake flame in a droplet group, leading to the change of the drag with inlet velocities. It is found that the drag of droplets in the group is much smaller than that of a non-combusting particle in isothermal flows
O Colégio Estadual Dr. Raimundo Alves Torres, na perspectiva de seus agentes
Authors: Jorge Mateus Rodrigues , Rocha Amanda
Published: February 2023

Vencedor do Prêmio Mariza Corrêa, na modalidade Ensaio Audiovisual. Link para as gravações completas:https://drive.google.com/drive/folders/1tjPXD6nAF3-rjiIFR2Ch-FOsWHCKhKo-?usp=saring
Analysis of the Association of Allergic Disease in Pediatric Patients with Hereditary Angioedema
Authors: AYDOĞDU Ayşe , AYDOĞDU Ali
Published: February 2023

Hereditary angioedema (HAE) is a rare autosomal dominant disease that is derived from the deficiency or dysfunction of C1 esterase inhibitor (C1-INH). In studies about the diseases that can accompany hereditary angioedema, allergic diseases occur more frequently compared to the healthy population but no studies on this issue have been carried out. This study was conducted in order to determine the frequency of the comorbidity of atopic sensitivity and allergic diseases in patients with hereditary angioedema. 32 patients who were diagnosed with hereditary angioedema in the Paediatric Allergy Polyclinic of Mersin City Hospital between 2019 and 2021 were included in the study. In these patients, the information about the existence of atopic diseases was obtained from their files and recorded. While asthma was observed in 6 (18.8%), allergic rhinitis in 18 (46.9%), and urticaria in 2 (6.2%) patients, dermatitis was not observed in any of the patients. While Fx5 test was positive in 5 (15.6%) patients, inhalant allergen mix sps IgE was positive in 7 (25.9%) patients. The IgE value was above 100 in 12 (52.2%) patients, and the eosinophil level was above 4% in 16 (50%) patients. In conclusion, we speculate in this study that the association of atopic disease and atopic sensitivity is observed more frequently in patients with angioedema than in the healthy population. However, a study with a larger sample is necessary to confirm this finding.
Life cycle oriented low carbon manufacturing of mechanical equipment: method and application
Authors: Huang Haihong , Zou Xiang , Li Lei , Xiong Wei , Gan Lei , Liu Zhifeng
Published: February 2023

Mechanical equipment is a significant contributor to carbon emissions. By analyzing the life cycle carbon emissions of mechanical equipment, it can be obtained that the consumption of materials and energy are the key factors. Focusing on decreasing material and energy consumption in the life cycle of mechanical equipment, a series of low carbon design strategies are proposed, including material selection, lightweight design, and design for disassembly and recycling; specifically, in this paper, low carbon operation strategies on the machine and workshop levels are discussed. Operations including power matching, energy recovery, and transmission chain shortening can be performed at the machine level, as well as scheduling and production optimization at the workshop level. The proposed method is applied to a piece of typical equipment, a hydraulic forming press, and results show that the proposed low carbon manufacturing methods have significant carbon emission reduction potential. Combined with current research hotspots, the integration of design methods and tools and the carbon emission reduction techniques enabled by intelligent manufacturing are future directions.
Analysis of the effectiveness of e-customer service platforms on customer satisfaction at ABSA, Botswana
Authors: Chiguvi Douglas
Published: February 2023

The study's primary objective was to analyze the effectiveness of e-customer service platforms on customer satisfaction in commercial banks in Botswana, using ABSA bank as a case study. The secondary objectives were to assess the effectiveness of reliability, responsiveness, assurance, empathy and tangibles of e-customer service platforms on customer satisfaction at ABSA bank. A positivist research philosophy was adopted. A cross-sectional survey design was used to collect data and probability sampling was employed. Data were collected from 180 customers who use ABSA e-customer services platforms using a structured questionnaire with Likert-type questions. Reliability was assessed using Cronbach’s alpha (?). Data were analysed using descriptive statistics, which include mean and standard deviation. Regression and correlation were applied to test research hypotheses. Results indicate that reliability, responsiveness, assurance, empathy and tangibles of e-customer services platforms at ABSA are positively linked to customer satisfaction. ABSA Bank management is therefore recommended to focus on continuous improvement on customer experiences to satisfy customers. Thus, ABSA should ensure that its services are unique, unforgettable and memorable such that customers are satisfied and share the positive word of mouth about the benefits offered by the bank. ABSA should also consider customer experience and continuous improvement of digital banking platforms as tools that can be used to increase customer satisfaction and loyalty. It is recommended that future studies be carried out across other banks in Botswana and the African context as well.
The influence of financial literacy and financial attitude on financial management behavior
Authors: Ratnawati Kusuma , Azzahra Nabila , Dewanta Prasetya Putra
Published: February 2023

The goal of this research is to determine how financial literacy and financial attitude influence financial management behavior in Culinary MSMEs in Rawamangun, East Jakarta City. The type of research used is explanatory research. The sampling method is probability with area sampling. Samples were collected from 50 Culinary MSMEs actors in East Jakarta's Rawamangun Urban Village. The primary data used are questionnaire responses on a five-point Likert scale. Multiple Regression Analysis was used to analyze the data, aided by SPSS version 25.0. Based on the testing results, the two hypotheses show that financial literacy and financial attitudes positively and significantly influence financial management behavior in Culinary MSMEs actors in Rawamangun Urban Village. Theoretically, this study recommends further research to analyze in-depth other variables that shape the financial management behavior of Culinary MSMEs in Rawamangun Urban Village. Practically, this study highlights the need for education and literacy to strengthen the financial management behavior of culinary entrepreneurs, with the aim of improving the economy and business through insightful activities such as education, and training courses that focus on savings, loans, investments and insurance.
A Solution of The Collatz Conjecture Problem
Authors: duan baoyuan
Published: February 2023

Build a special identical equation, use its calculation characters to prove and search for solution of any odd converging to 1 equation through (*3+1)/2^k operation, and get a solution for this equation, which is exactly same with that got from calculating directly. Then give a specific example to verify. Thus prove the Collatz Conjecture is true. Furthermore, analysis the even and odd sequences produced by iteration calculation during the procedure of searching for solution, build a weight function model, prove it decrease progressively to 0, build another complement weight function model, prove it increase to its convergence state. Indicate that this kind of iteration calculation has determined direction, and gradually regularly converges.
Pipeline to Design Inbred Lines and F1 Hybrids of Leaf Chicory (Radicchio) Using Male-sterility and Genotyping-by-sequencing
Authors: Scariolo Francesco , Palumbo Fabio , Farinati Silvia , Barcaccia Gianni
Published: February 2023

Chicory, a horticultural crop cultivated worldwide, presents many botanical varieties and local biotypes. Among these, Italian radicchio group cultivars of pure Cichorium intybus L. and interspecific hybrids with Cichorium endivia L., as the “Red of Chioggia” biotype which in turn includes several phenotypes. This study deals with a pipeline for the marker-assisted breeding of F1 hybrids: it presents the genotyping-by-sequencing results of four elite inbred lines using a RADseq approach and an original molecular assay based on CAPS markers for screening mutants with nuclear male-sterility in radicchio of Chioggia. Two thousand nine hundred fifty-three SNP-carrying RADtags were identified and used to compute the actual estimates of homozygosity, and overall genetic similarity and uniformity of the populations, as well as to determine their genetic distinctiveness and differentiation. Molecular data were further used to investigate the genomic distribution of the RADtags among the two Cichorium species, allowing their mapping in 1,131 and 1,071 coding sequences in chicory and endive, respectively. In parallel, an assay to screen the genotype at the male-sterility locus Cims-1 was developed to discriminate wild-type and mutant alleles of the causative gene myb80-like. Moreover, a RADtag mapped close to this genomic region proved the potential application of this method for future marker-assisted selection tools. Finally, combining the genotype information of the core collection, the best ten individuals from each inbred line were selected to compute the observed genetic similarity as a measure of uniformity as well as the expected homozygosity and heterozygosity estimates scorable by the putative progenies derived from selfing (pollen parent) and full-sibling (seed parent) or pair-wise crossing (F1 hybrids). This predictive approach was conducted as a pilot study for understanding the potential application of RADseq in improving molecular breeding strategies aimed at the development of inbred lines and F1 hybrids in leaf chicory.
Harnessing the Power of Online Inter-Class Tournaments to Imitate, Recombine, and Craft Innovative STEM Teaching Strategies
Authors: Araya Roberto
Published: February 2023

There are increasing calls in education for deeper integration of disciplines and better preparation for the personal and job challenges of a fast-changing and smarter society. Thus, we need to search for new effective didactic strategies. However, current classrooms are isolated. They practically never connect. This hinders the exchange of ideas. It inhibits imitation and recombination, the basic blocks of cultural evolution and innovation. In this paper, we analyze online inter-class tournaments. These are lessons where entire elementary or middle school classes interconnect synchronously and play an educational game. These are new types of academic activities, and only possible thanks to digital communication technology. In this paper, we examine four online tournaments, we analyze how feasible it is to carry them out and the benefits they bring. One tournament is for teaching machine learning and statistics. The second one teaches the conservation of momentum in physics and an engineering optimization challenge. The third tournament is for learning to solve word problems. The fourth one is for teaching natural and sexual selection along with developing statistical and population thinking. We found that these inter-class tournaments are feasible to implement in schools and that they are a promising mechanism to facilitate imitation, recombination, and innovation of teaching strategies.
Energy-efficient power cap configurations through Pareto Front Analysis and Machine Learning Categorization
Authors: Cabrera Alberto , Almeida Francisco , Castellanos-Nieves Dagoberto , Oleksiak Ariel , Blanco Vicente
Published: February 2023

The growing demand for more computational resources has increased the overall energy consumption in computer systems. To support the increasing requirements, power and energy consumption have to be considered as a constraint to execute software. Modern architectures provide tools to manage directly the power constraints of a system. The Intel Power Cap is a relatively recent tool developed to offer fine control of power usage to users at a central processing unit (CPU) level. We propose a methodology to analyze the performance and the energy efficiency trade-offs using this power cap technology for a given algorithm. We extract a Pareto front for the multi-objective performance and energy problem to represent multiple feasible configurations for both objectives. We perform an extensive experimentation to categorize the different algorithms to reduce the total amount of optimal power cap configurations. We propose the use of Machine Learning (ML) clustering techniques to categorize any algorithm in the target architecture.The use of Machine Learning allows to automate the procedure and simplifies the effort required to solve the optimization problem.We present a practical case where we categorize the kernels using ML techniques, with the option to include a new algorithm into an already existing categorization.
Observation of spatiotemporal temperature-dependent catalytic activation within individual catalyst particle at work
Authors: Tian Yu , Gao Mingbin , Xie Hua , Zhou Xuelian , Qiao Qinglong , Xu Shuliang , Xu Zhaochao , Ye Mao , Liu Zhongmin
Published: February 2023

Temperature distribution within individual catalyst particle, dominating the underlying reaction mechanism at local active sites, has seldom been studied in heterogeneous catalysis. Here, we propose to use the confocal two-photon microscopy, together with state-of-the-art upconversion luminescence (UL) imaging, to measure the spatiotemporal-resolved temperature within individual catalyst particle in industrially significant methanol-to-hydrocarbons reaction. Catalyst particles containing H-ZSM-5 zeolites and functional nano-thermometers were fabricated using micro-fluidic chips. It directly illustrates that the active-sites density and particle size can alter the temperature distribution within single catalyst particle. And the temperature heterogeneity plays a decisive role in the activation of hydrocarbon-pool species and utilization of active sites, as elucidated by combining structural illumination imaging, infrared microscopy and simulations. We expect this work opens a venue for unveiling reaction mechanism and kinetics within single catalyst particle of industrial interest by considering temperature heterogeneity.
Effects of ultrafiltration followed by heat or high-pressure treatment on camel and bovine milk cheeses
Authors: Mbye Mustapha , Ayyash Mutamed , Abu-Jda Ismail , Kamleh Rabih , Kamal-Eldin Afaf , Mohamed Huda
Published: February 2023

The aim of this study was to assess the effects of ultrafiltration (UF) combined with high-pressure processing (HPP) or heat treatment on the quality of soft cheese produced from camel milk (CM) or bovine milk (BM). Milk was concentrated by UF (0, 1, and 2-fold) before treatment with HPP at 350 MPa or 550 MPa for 5 min at 4°C or by pasteurization at 65°C for 30 min or at 75°C for 30 s. Cheeses were produced using starter cultures and camel chymosin and pH, yield, proximate composition, texture profile, rheological properties, and protein profiles were determined. The highest yield of BM cheese (26%) was observed under the treatment with 2-fold UF combined with HPP at 550 MPa. CM cheese had the highest storage and loss moduli as well as the total solid and protein content under this treatment. According to SDS-PAGE electrophoresis, CM cheeses were more susceptible to proteolysis and had a higher number of low-molecular-weight bands, indicating the involvement of some active enzymes compared with BM cheeses. In conclusion, UF combined with HPP can enhance the cheese total solid content and gel structure in CM cheese products compared with heat treatment.
Inflammation from Sleep Fragmentation Starts in the Periphery Rather than Brain in Male Mice
Authors: Nguyen Van Thuan , Fields Cameron J. , Ashley Noah T.
Published: February 2023

Obstructive sleep apnea is increasing worldwide, leading to disordered sleep patterns and inflammatory responses in brain and peripheral tissues that predispose individuals to chronic disease. Pro-inflammatory cytokines activate the inflammatory response and are normally regulated by glucocorticoids secreted from adrenal glands. However, the temporal dynamics of inflammatory responses and hypothalamic-pituitary-adrenal (HPA) axis activation in relation to acute sleep fragmentation (ASF) are undescribed. Male C57BL/6J mice were exposed to ASF or control conditions (no ASF) over specified intervals (1, 2, 6, and 24 h) and cytokine gene expression (IL-1beta, TNF-alpha) in brain and peripheral tissues as well as serum glucocorticoid and interleukin-6 (IL-6) concentration were assessed. The HPA axis was rapidly activated, leading to elevated serum corticosterone from 1–24 h of ASF compared with controls. This activation was followed by elevated serum IL-6 concentration from 6–24 h of ASF. The tissue to first exhibit increased pro-inflammatory gene expression from ASF was heart (1 h of ASF). In contrast, pro-inflammatory gene expression was suppressed in hypothalamus after 1 h of ASF, but elevated after 6 h. Because the HPA axis was activated throughout ASF, this suggests that brain, but not peripheral, pro-inflammatory responses were rapidly inhibited by glucocorticoid immunosuppression.
Impact of the Second Victim Support Program to the Just Culture Perception among Nurses
Authors: Logroño Kenneth Jun
Published: February 2023

Aim
Assess the impact of the second victim support program to the just culture perception of nurses.
Method
A descriptive, cross-sectional study using the validated Just Culture Assessment Tool (JCAT) conducted last November 2020 to December 2020 in a large referral hospital in the Middle East. The total response rate was 82%. The just culture perception of 212 staff nurses is presented through a dimension-level mean scores of each group based on the second-victim exposure (non-victims, second victims with support, and second victims without support).
Results
Results revealed that the second victim with the support group got the highest overall mean score (5.13 ± 0.13), while second victim with support and second-victim without support is (5.15 ± 0.10) and is (5.45 ± 0.11), respectively. ANOVA and Tukey HSD multiple comparisons test showed a significant difference in just culture mean scores between second victims with support and non-victims are significantly different at a 5% level of significance (p-value = 0.0386 < 0.005).
Conclusion
A better perceptual score of just culture was linked to perceived institutional support for second victims.
Clinical Evaluation of Anti-inflammatory and Analgesic Activities of AQUA-TURM (branded extract of Curcuma longa) in Individuals Suffering from Osteoarthritis of Knee(s): A Randomized, Double Blind, Placebo Controlled clinical study
Authors: Pande Shishir , Godatwar Pawankumar , Agiwal Sachin , Khatau Kiran , Tamoli Sanjay
Published: February 2023

Background: Anti-inflammatory and analgesic activities of Curcuma longa extract can be helpful in the management of Osteoarthritis.
Objectives: to evaluate the anti-inflammatory and analgesic activities of AQUATURM® (branded extract of Curcuma longa) in individuals suffering from Osteoarthritis of Knee joint
Methods: In present randomized, double blind, placebo controlled clinical study, a total 60 participants suffering from Osteoarthritis of the knee joint were randomized in two groups through a double-blinded procedure. AQUA-TURM® or its matching placebo was given in a dose of 1 capsule of 250 mg twice daily after meals for 90 days. Of these, 56 subjects completed the study (26 in AQUA-TURM® group and 30 in placebo group). Assessment of comparative change in knee joint pain on VAS, WOMAC Index was done on monthly intervals. Other parameters like time to walk 50 feet, requirement of painkillers, changes in the CRP levels and safety assessment through adverse event monitoring and laboratory parameters was done.
Results:
A significant reduction (p < 0.05) in pain was observed on VAS scale with the use of AQUA-TURM® as compared to placebo over a period of 90 days. On the WOMAC index, significant reduction (p < 0.05) was observed on the domains of pain and stiffness. A significant reduction was observed on CRP levels. AQUA-TURM® did not produce any significant adverse effects on clinical and laboratory parameters and was well tolerated.
Conclusion: Supplementation of AQUATURM® in individuals suffering from Osteoarthritis of Knee joint showed significant reduction in pain and swelling showing its analgesic and anti-inflammatory effect.
An Energy-Efficient Synchronization Scheme for Multi-hop WSNs through Passive Listening
Authors: Ayaluru SivaRama Krishna
Published: February 2023

Energy Conservation in Wireless Sensor Networks(WSNs) has emerged as challenging research in recenttimes. Considering the limited energy of batteries of sensor nodes, it is requiredto synchronize the nodes of a multi-hop WSN with as less energy as possible.Recently a hybrid synchronization scheme is proposed for practical WSNs,which is a combination of one way message dissemination and time-stamp freesynchronization. Passive listening can be employed additionally in the hybridapproach. In this work, we propose an energy efficient synchronizing scheme to synchronize every node of a multi-hop WSN. The proposed scheme, which minimizes energy consumption and lowers communication overhead, is a hybrid combination of passive listening based time-stamp free synchronization and one-way message dissemination. We derive MSE, CRLB of the estimates of clock skew and offset and observe that the proposed scheme is energy efficient in synchronizing n number of nodes of a multi-hop WSN compared to the existing scheme.
Modeling of Multilayer Perceptron Neural Network Hyperparameter Optimization and Training
Authors: Elansari Taoufyq , Ouanan Mohammed , Bourray Hamid
Published: February 2023

The multilayer perceptron (MLP) is an artificial neural network composed of one or more hidden layers. MLP has an extensive array of classification and regression applications in a wide range of domains. Selecting the right neural network architecture to solve a specific problem is one of the major areas of neural network research. The number of neurons in the hidden layers and the initial weights have a great effect on the convergence of MLP training algorithms. This paper presents a technique termed hyperparameter optimization model for the multilayer perceptron. We model in terms of mixed-variable optimization problems with nonlinear constraints. To solve the obtained model, a hybrid algorithm is used, based on the genetic algorithm and the backpropagation algorithm. The numerical results demonstrate the efficiency of the technique presented in this paper, and the advantages of the proposed model vis-a-vis the previous state-of-the-art model.
Targetable fibroblast phenotypes and EMT malignant cell states cooperate to promote tumor progression in esophageal adenocarcinoma
Authors: Walker Robert C. , Breininger Stella P. , Sharpe Benjamin P. , Harrington Jack , Reddin Ian , Tse Carmen , Rajak Rushda , Hayden Annette , Rahman Saqib , Grace Ben , Izadi Fereshteh , West Jonathan , Secrier Maria , Walters Zoë S. , Rose-Zerilli Matthew J.J. , Underwood Timothy J.
Published: February 2023

Background: Esophageal adenocarcinoma (EAC) is usually resistant to cytotoxic therapies and immunotherapies have gained little traction. Cancer-associated fibroblasts (CAF) are a major stromal cell population in the EAC tumor microenvironment associated with prognosis and treatment outcomes. Recent evidence suggests that cancer cell phenotypes related to EMT may determine CAF heterogeneity, but the molecular and cellular biology that underlies myofibroblast fate in EAC is not well understood.
Methods: To obtain the most comprehensive profile of CAF heterogeneity in EAC, we performed histopathologic, single-cell RNA sequencing and transcriptomic analyses on 28 samples from 26 patients and prognostic validation using two EAC cohorts from genomic consortia.
Results: Combining histologic and molecular profiles revealed five CAF phenotypes, including three myofibroblast phenotypes, associated with EMT-related signatures in EAC cells and cellular interactions that promote tumor progression and metastasis. We identified a specific myofibroblast subtype (CAF5) in close proximity to cancer cells and tumor vasculature with exclusive expression of TRPA1, offering a potential therapeutic vulnerability. We reconstructed CAF differentiation trajectories from esophagus-resident universal fibroblasts to identify candidate genes central to the CAF phenotype, and used this knowledge to construct a combined EMT-myofibroblast four gene signature (GSN, ATF1, ZEB2 and POSTN) that was highly prognostic in EAC and several other solid tumors.
Conclusions: This study stratifies EAC patients into two prognostic groups and reports important data supporting a cancer – CAF signalling axis, promoting myofibroblastic differentiation, that may inform more effective treatment strategies.
Digitale Kompetenz-Bildung zwischen institutionellen Anforderungen und lebensweltlichen Zugehörigkeiten
Authors: Dalhaus Eva
Published: February 2023

Im aktuellen bildungspolitischen und schulpädagogischen Diskurs werden im Zusammenhang mit Digitalisierungsmassnahmen in Schulen Kompetenzanforderungen deutlich, die die heterogene Lerner:innenschaft dazu befähigen sollen, «sich in einer digitalisierten Gesellschaft zurechtzufinden» (Autorengruppe Bildungsberichterstattung 2020). Unberücksichtigt bleiben die Erfahrungen von Kindern und Jugendlichen in digitalen Jugendkulturen, in deren Rahmen sie mit ihrem Wunsch nach Anerkennung und Zugehörigkeit ohne Anleitung quasi «nebenbei» grundlegende personale, soziale und anwendungsbezogene fachliche Kompetenzen erwerben. Der Beitrag fragt aus einer diversitätssensiblen wissenschaftlich-analytischen Perspektive unter Bezugnahme auf die Konstruktion von Zugehörigkeit (Hall 2004; Mecheril 2003) und Habitus (Bourdieu 1992; Kramer 2014) nach den lebensweltlichen Bedürfnissen und Erfahrungen von Schüler:innen, stellt diese gegenwärtig sichtbaren institutionell-digitalen Kompetenzanforderungen in Schulen gegenüber und arbeitet auf der Grundlage der Annahme eines konstruierten «digital divides» Problematiken und Gefahren der Differenzierung und Verfestigung von Chancenungleichheit heraus. Die Ergebnisse verweisen in pädagogisch-didaktischer Hinsicht auf die Notwendigkeit der Etablierung einer digitalen Lernkultur, die die Herausbildung einer Kompetenz zum Ziel hat, in deren Rahmen die selbstbestimmte und gleichermassen sozial verantwortungsvolle Herstellung lebensweltlich-digitaler Zugehörigkeiten durch Schüler:innen unabhängig von ihrer «Ethnie», ihres «Geschlechts», ihrer «Bildungsposition» etc. möglich wird.
Entscheidend ist nicht die Aussage, sondern die Art und Weise der Protokollierung
Authors: Odermatt Luca , Ege Gian
Published: February 2023

Einvernahmeprotokolle sind in Strafverfahren von erheblicher Bedeutung. Sie sind allerdings auch eine grosse Fehlerquelle. Trotzdem wurde im Rahmen der im Juni 2022 beschlossenen StPO-Revision darauf verzichtet, eine Aufzeichnungsverpflichtung für Einvernahmen im Vorverfahren einzuführen. Der vorliegende Aufsatz zeigt auf, welche Funktionen Einvernahmeprotokollen im Strafverfahren zukommt und welche Fehlerquellen bestehen. Vor diesem Hintergrund wird dargelegt, dass eine audiovisuelle Aufzeichnung der Einvernahmen verschiedene Probleme beheben würde und es daher sinnvoll wäre, eine entsprechende Aufzeichnungspflicht einzuführen.

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Les procès-verbaux des auditions constituent un élément essentiel en procédure pénale. Cependant, ils peuvent être à l'origine de nombreuses erreurs. Nonobstant ce fait, le législateur a renoncé, dans le cadre de la révision du CPP adoptée en juin 2022, à introduire une obligation d'enregistrement des interrogatoires durant la phase préliminaire de la procédure. Cet article présente les fonctions des procès-verbaux des auditions en procédure pénale ainsi que les sources d'erreurs potentielles. Dans ce contexte, il a été démontré que l'enregistrement audiovisuel des auditions permettrait de remédier à différents types de dysfonctionnements et qu'il serait judicieux d'introduire une obligation d'enregistrement en ce sens.