bluuebunny/crossref_metadata_2025 huggingface dataset:
Management in primary care at the time of a suicide attempt and its impact on care post-suicide attempt: an observational study in the French GP sentinel surveillance system
Authors: Younes Nadia , Rivière Mathieu , Urbain Frédéric , Pons Romain , Hanslik Thomas , Rossignol Louise , Chan Chee Christine , Blanchon Thierry
Published: March 2020

Background

We aimed to describe primary care management at the time of a suicide attempt (SA) and after the SA.

Methods

An observational (cross-sectional) study was conducted among 166 sentinel GPs within France (a non-gatekeeping country) between 2013 and 2017 for all GP’s patients who attempted suicide. Measurements: frequency of patients 1) managed by the GP at the time of the SA, 2) addressed to an emergency department (ED), 3) without care at the time of the SA, and 4) managed by the GP after the SA and factors associated with GP management at the time of and after the SA.

Results

Three hundred twenty-one SAs were reported, of which N = 95 (29.6%) were managed by the GP at the time of the SA, N = (70.5%) were referred to an ED, and N = (27.4%) remained at home. Forty-eight (14.9%) patients did not receive any care at the time of the SA and 178 (55.4%) were managed directly by an ED. GPs were more likely to be involved in management of the patient at the time of the SA if they were younger (39.2% for patients < 34 years old; 22.9% for those 35 to 54 years old, and 30.3% for those more than 55 years old p = 0.02) or the SA involved a firearm or self-cutting (51.9%) versus those involving drugs (23.7%); p = 0.006). After the SA, GPs managed 174 patients (54.2%), more often (60%) when they provided care at home at the time of the SA, p = 0.04; 1.87 [1.07; 3.35]. No other factor was associated with management by GPs after the SA.

Conclusions

The study faced limitations: data were not available for patients managed solely by specialists during their SA and results may not be generalisable to countries with a stronger gatekeeping system. We concluded that GPs are involved in the management of patients at the time of a SA for a third of patients. EDs are the major provider of care at that time. Half patients consulted GPs after the SA and connections between GPs and ED upon discharge should be improved.
Gingival phenotypes and their relation to age, gender and other risk factors
Authors: Alhajj Wadhah Abdulnasser
Published: March 2020

Background

Careful consideration and assessment of the type of phenotype has gained a fundamental importance in the treatment planning for any patient. We evaluated the prevalence of gingival phenotypes in a sample of Yemeni population and to explore its relationships to gender, age and other risk factors.

Methods

This cross-sectional study was performed among 456 patients. All maxillary anterior teeth were included for all parameters and 1st molars were included for gingival thickness measurements. All patients included in this study were systemically healthy and presented no dental crowding. Four clinical parameters were systematically recorded: Gingival thickness (GT), Width of keratinized gingiva (WKG), Crown width/ crown length (CW/CL) ratio and Papilla height (PH). Scores obtained from different parameters measurements were recorded and analyzed using non-parametric tests whereP-value < 0.05 was considered significant. One examiner performed all measurements.

Results

The mean age was 29.9 ± 8.26 years. Of 456 recruited subjects, 83 (18.2%) subjects had thin, 69 (15.1%) had thick GT and 304 (66.7%) were placed in non-categorized (1.5–2 mm) GT. Square crown shape was found in 210 (44.1%) patients and 245 patients (55.9%) showed rectangular shape. Regarding WKG, 114 (25%) patients had width < 4 mm, 319 (70%) had width 4.1–8 mm and 23 (5%) patients had width >  8 mm. There was no significant difference between males and females for GT measurements. Regarding WKG, results showed that the prevalence of WKG 4.1–8 mm was more among females while males had more prevalence of ≤4 mm with significance difference. PH showed no significant differences between males and females. Regarding age, there was no significant differences between patients ≤25 years and >  25 years for all gingival parameters measurements. The relationship of smoking with different gingival parameters also showed no significant differences between smokers and non-smokers. Similarly, relationship of khat chewing with different gingival parameters showed no significant difference. Regarding inter-relationship between parameters, thin GT was associated with rectangular tooth form while square and quadrate forms are more associated with “1.5–2 mm” GT. WKG of ≤4 mm was associated with rectangular tooth form while WKG >  8 was more associated with square and quadrate forms with no significant difference. Results showed significant association between thin GT with 4.1–8 mm WKG.

Conclusion

Yemeni population had more prevalence of “1.5–2 mm” GT, rectangular crown shape and WKG from 4.1–8 mm. Regarding interrelationship between gingival parameters, GT showed obvious relationship with WKG, CW/CL ratio and PH. WKG with CW/CL also showed significant relationship while no relationship was shown between other gingival phenotype parameters.
Community mobilisation to prevent violence against women and girls in eastern India through participatory learning and action with women’s groups facilitated by accredited social health activists: a before-and-after pilot study
Authors: Nair Nirmala , Daruwalla Nayreen , Osrin David , Rath Suchitra , Gagrai Sumitra , Sahu Rebati , Pradhan Hemanta , De Megha , Ambavkar Gauri , Das Nibha , Dungdung G. Pramila , Mohan Damini , Munda Bahadur , Singh Vijay , Tripathy Prasanta , Prost Audrey
Published: March 2020

Background

Almost one in three married Indian women have ever experienced physical, sexual, or emotional violence from husbands in their lifetime. We aimed to investigate the preliminary effects of community mobilisation through participatory learning and action groups facilitated by Accredited Social Health Activists (ASHAs), coupled with access to counselling, to prevent violence against women and girls in Jharkhand, eastern India.

Methods

We piloted a cycle of 16 participatory learning and action meetings with women’s groups facilitated by ASHAs in rural Jharkhand. Participants identified common forms of violence against women and girls, prioritised the ones they wanted to address, developed locally feasible strategies to address them, implemented the strategies, and evaluated the process. We also trained two counsellors and two ASHA supervisors to support survivors, and gave ASHAs information about legal, health, and police services. We did a before-and-after pilot study involving baseline and endline surveys with group members to estimate preliminary effects of these activities on the acceptability of violence, prevalence of past year emotional and physical violence, and help-seeking.

Results

ASHAs successfully conducted monthly participatory learning and action meetings with 39 women’s groups in 22 villages of West Singhbhum district, Jharkhand, between June 2016 and September 2017. We interviewed 59% (679/1149) of women registered with groups at baseline, and 63% (861/1371) at endline. More women reported that violence was unacceptable in all seven scenarios presented to them at endline compared to baseline (adjusted Odds Ratio [aOR]: 1.87, 95%: 1.39–2.52). Fewer women reported experiencing emotional violence from their husbands in the last 12 months (aOR: 0.55, 95% CI: 0.43–0.71), and more sought help if it occurred (aOR: 2.19, 95% CI: 1.51–3.17). In addition, fewer women reported experiencing emotional or physical violence from family members other than their husbands in the last 12 months (aOR: 0.41, 95% CI: 0.32–0.53, and aOR: 0.36, 95% CI: 0.26–0.50, respectively).

Conclusion

Combining participatory learning and action meetings facilitated by ASHAs with access to counselling was an acceptable strategy to address violence against women and girls in rural communities of Jharkhand. The approach warrants further implementation and evaluation as part of a comprehensive response to violence.
Waist circumference is associated with major adverse cardiovascular events in male but not female patients with type-2 diabetes mellitus
Authors: Xing Zhenhua , Peng Zhenyu , Wang Xiaopu , Zhu Zhaowei , Pei Junyu , Hu Xinqun , Chai Xiangping
Published: March 2020

Background

Although studies have shown that waist circumference (WC) is positively associated with an increased risk of cardiovascular diseases among the normal population, few studies have investigated WC in patients with type-2 diabetes mellitus (T2DM).

Methods

This was a post hoc analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study. The Cox proportional hazards models was used to investigate the relationship between WC and major adverse cardiovascular events (MACEs) in T2DM patients with cardiovascular disease (CVD) or high risk factors of CVD.

Results

A total of 10,251 T2DM patients (6299 men [61.4%], 3952 women [38.6%]) were included in our analysis. The mean age was 64.0 ± 7.53 years. After a mean follow-up at 9.2 ± 2.4 years later, 1804 patients (event rate of 23 per 1000 person-years) had developed MACEs. MACEs rates in men and women were 18.0 and 26.0 events per 1000 person-years, respectively. After multivariable adjustment, each increase in WC of 1 SD increased the risk of MACEs (HR: 1.10, 95% CI 1.04–1.17; P < 0.01) in men, with a non-significant increase in MACEs (HR: 1.04, 95% CI 0.95–1.13; P = 0.40) in women. Compared with those in the first quartile of WC, male patients in the fourth quartile of WC had a hazard ratio (HR) of 1.24 (95% CI 1.05–1.46) for MACEs; female patients in the fourth quartile of WC had an HR of 1.22 (95% CI 0.96–1.56) for MACEs.

Conclusions

Higher WC is associated with increased risks of MACEs in male but not female T2DM patients.

Trial registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT00000620)
Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications
Authors: Cheng Jian , Meng Jinli , Zhu Lei , Peng Yong
Published: March 2020

Gliomas are complex and heterogeneous brain tumors with poor prognosis. Glioma cells can communicate with their surroundings to create a tumor-permissive microenvironment. Exosomes represent a new means of intercellular communication by delivering various bioactive molecules, including proteins, lipids and nucleic acids, and participate in tumor initiation and progression. Noncoding RNAs (ncRNAs) including microRNA, long-noncoding RNA, and circular RNA, account for a large portion of human transcriptome and play important roles in various pathophysiological processes, especially in cancers. In addition, ncRNAs can be selectively packaged, secreted and transferred between cells in exosomes and modulate numerous hallmarks of glioma, such as proliferation, invasion, angiogenesis, immune-escape, and treatment resistance. Hence, the strategies of specifically targeting exosomal ncRNAs could be attractive therapeutic options. Exosomes are able to cross the blood brain barrier (BBB), and are readily accessible in nearly all types of human biofluids, which make them the promising biomarkers for gliomas. Additionally, given the biocompatibility of exosomes, they can be engineered to deliver therapeutic factors, such as RNA, proteins and drugs, to target cells for therapeutic applications. Here, we reviewed current research on the roles of exosomal ncRNAs in glioma progression. We also discussed their potential clinical applications as novel biomarkers and therapeutics.
Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E
Authors: Robert Jerome , Button Emily B. , Martin Emma M. , McAlary Luke , Gidden Zoe , Gilmour Megan , Boyce Guilaine , Caffrey Tara M. , Agbay Andrew , Clark Amanda , Silverman Judith M. , Cashman Neil R. , Wellington Cheryl L.
Published: March 2020

Background

Several lines of evidence suggest that high-density lipoprotein (HDL) reduces Alzheimer’s disease (AD) risk by decreasing vascular beta-amyloid (Aβ) deposition and inflammation, however, the mechanisms by which HDL improve cerebrovascular functions relevant to AD remain poorly understood.

Methods

Here we use a human bioengineered model of cerebral amyloid angiopathy (CAA) to define several mechanisms by which HDL reduces Aβ deposition within the vasculature and attenuates endothelial inflammation as measured by monocyte binding.

Results

We demonstrate that HDL reduces vascular Aβ accumulation independently of its principal binding protein, scavenger receptor (SR)-BI, in contrast to the SR-BI-dependent mechanism by which HDL prevents Aβ-induced vascular inflammation. We describe multiple novel mechanisms by which HDL acts to reduce CAA, namely: i) altering Aβ binding to collagen-I, ii) forming a complex with Aβ that maintains its solubility, iii) lowering collagen-I protein levels produced by smooth-muscle cells (SMC), and iv) attenuating Aβ uptake into SMC that associates with reduced low density lipoprotein related protein 1 (LRP1) levels. Furthermore, we show that HDL particles enriched in apolipoprotein (apo)E appear to be the major drivers of these effects, providing new insights into the peripheral role of apoE in AD, in particular, the fraction of HDL that contains apoE.

Conclusion

The findings in this study identify new mechanisms by which circulating HDL, particularly HDL particles enriched in apoE, may provide vascular resilience to Aβ and shed new light on a potential role of peripherally-acting apoE in AD.
A model study for the manufacture and validation of clinical-grade deciduous dental pulp stem cells for chronic liver fibrosis treatment
Authors: Iwanaka Tsuyoshi , Yamaza Takayoshi , Sonoda Soichiro , Yoshimaru Koichiro , Matsuura Toshiharu , Yamaza Haruyoshi , Ohga Shouichi , Oda Yoshinao , Taguchi Tomoaki
Published: March 2020

Background

Human deciduous pulp stem cells (hDPSCs) have remarkable stem cell potency associated with cell proliferation, mesenchymal multipotency, and immunosuppressive function and have shown beneficial effects in a variety of animal disease models. Recent studies demonstrated that hDPSCs exhibited in vivo anti-fibrotic and anti-inflammatory action and in vivo hepatogenic-associated liver regeneration, suggesting that hDPSCs may offer a promising source with great clinical demand for treating liver diseases. However, how to manufacture ex vivo large-scale clinical-grade hDPSCs with the appropriate quality, safety, and preclinical efficacy assurances remains unclear.

Methods

We isolated hDPSCs from human deciduous dental pulp tissues formed by the colony-forming unit-fibroblast (CFU-F) method and expanded them under a xenogeneic-free and serum-free (XF/SF) condition; hDPSC products were subsequently stored by two-step banking including a master cell bank (MCB) and a working cell bank (WCB). The final products were directly thawed hDPSCs from the WCB. We tested the safety and quality check, stem cell properties, and preclinical potentials of final hDPSC products and hDPSC products in the MCB and WCB.

Results

We optimized manufacturing procedures to isolate and expand hDPSC products under a XF/SF culture condition and established the MCB and the WCB. The final hDPSC products and hDPSC products in the MCB and WCB were validated the safety and quality including population doubling ability, chromosome stability, microorganism safety, and stem cell properties including morphology, cell surface marker expression, and multipotency. We also evaluated the in vivo immunogenicity and tumorigenicity and validated in vivo therapeutic efficacy for liver regeneration in a CCl4-induced chronic liver fibrosis mouse model in the final hDPSC products and hDPSC products in the WCB.

Conclusion

The manufacture and quality control results indicated that the present procedure could produce sufficient numbers of clinical-grade hDPSC products from a tiny deciduous dental pulp tissue to enhance clinical application of hDPSC products in chronic liver fibrosis.
Spontaneous hemispheric ventricular collapse and subarachnoid haemorrhages in a dog with congenital hydrocephalus internus
Authors: Olszewska Agnieszka , Farke Daniela , Schmidt Martin Jürgen
Published: March 2020

Background

Overdrainage and collapse of the hemispheres is a potential severe complication after surgical treatment of internal hydrocephalus using ventriculoperitoneal shunts. Here we describe a case of a spontaneous hemispheric ventricular collapse in an untreated dog with congenital hydrocephalus internus.

Case presentation

A twelve-week-old, male, intact Golden Retriever was presented with a history of peracute obtundation, impaired vision, and progressive gait abnormalities of all limbs for three days. Neurological examination revealed a dome shaped skull, a broad-based stance and a moderate cerebellar ataxia. The postural responses were markedly delayed in all limbs. Moderate ventro-lateral strabismus, vertical nystagmus and absent menace response were observed bilaterally. Clinical signs indicated multifocal localisation (forebrain, cerebellum). Magnetic resonance imaging (MRI) showed dilation of all cerebral ventricles, irregular thinning of the periventricular white and grey matter, consistent with internal hydrocephalus. In addition, the hemispheres were collapsed at the right temporal and left frontal lobe with haemorrhage filling the adjacent subarachnoid space. The dog underwent left frontal and right temporal craniotomy for removal of the haemorrhage. The dog improved on all neurological signs and was discharged after seven days. A repeat MRI three months postsurgical intervention showed reexpansion of the cerebral hemispheres. Subarachnoid haemorrhages were markedly reduced.

Conclusions

Collapse of the hemispheres can occur spontaneously in dogs with hydrocephalus internus. Removal of the haemorrhage can improve clinical signs.
Transcriptional regulatory networks of methanol-independent protein expression in Pichia pastoris under the AOX1 promoter with trans-acting elements engineering
Authors: Shi Lei , Wang Jinjia , Wang Xiaolong , Zhang Yuanxing , Song Zhiwei , Cai Menghao , Zhou Xiangshan
Published: March 2020

To explore the differences in the intracellular transcriptional mechanism in carbon-derepressed and wild-typePichia pastorisstrains fed with three different carbon sources. RNA in carbon-derepressed (Δmig1Δmig2Δnrg1-Mit1; Mut) and wild-type (WT)P.pastorisfed with three different carbon sources (dextrose, glycerol, and methanol) were sequenced. Differentially expressed genes (DEGs) associated with these carbon sources were obtained and clustered into modules using weighted gene co-expression network analysis (WGCNA). Signaling pathway enrichment analysis was performed using KEGG, and protein to protein interaction (PPI) network was also constructed. A total of 2536 DEGs were obtained from three intersections, and some of them were enriched in carbon sources and involved in carbon metabolism, secondary metabolisms, and amino acid biosynthesis. Two modules, MEgreenyellow (involved in protease, oxidative phosphorylation, endoplasmic reticulum protein processing, folate carbon pool, and glycerol phospholipid metabolism pathways) and MEmidnightblue (involved in protease, endocytosis, steroid biosynthesis, and hippo signaling pathways) were significantly correlated with the strain type. Eight hub genes and two sub-networks were obtained from PPI network. Sub-network A enriched in proteasomes pathway while sub-network B enriched in ribosome pathway. The genes involved in carbon metabolism, secondary metabolic, and amino acid biosynthesis pathways changed significantly under different carbon sources. The changes in proteasome and ribosome activities play roles in carbohydrate metabolism in the methanol-free PAOX1start-up Mut strain.
Working environments and clothing conditions in the construction industry
Authors: Eom Ran-i , Lee Yejin
Published: March 2020

This study collected fundamental data on the current status of construction workers’ clothes in South Korea, and categorized it based on construction site environment and job position. The study was conducted via a survey of 102 construction workers comprising both managers and laborers. In addition, a detailed interview-based questionnaire was used to ask three workers at the construction site to adopt working postures and identify the most uncomfortable parts of their workwear. Construction working environments are influenced by seasonal changes and have been recognized as places where dangerous hazards may occur. Workers in the construction industry felt that their faces were the hottest parts of their bodies in summer and their hands were the coldest in winter. With respect to the clothing worn for work, the results showed that most managers wore company-supplied workwear but laborers did not. When personally purchasing workwear, managers bought items at outdoor shops, whereas laborers purchased theirs at local markets. Both laborers and managers indicated a need for new workwear designs with a greater emphasis on function. In the in-depth interviews, the respondents noted that they felt discomfort from the clothing in their backs, upper arms, thighs, knees, and hips as a result of their primary work postures. Furthermore, they noted the need for pockets of appropriate size and position according to their work. The functional requirements demanded from construction workwear were classified based on the study’s results.
Histological characteristics of advanced peri-implantitis bone defects in humans
Authors: Galárraga-Vinueza Maria Elisa , Tangl Stefan , Bianchini Marco , Magini Ricardo , Obreja Karina , Gruber Reinhard , Schwarz Frank
Published: March 2020

Background

Inflammatory osteolysis is the clinical hallmark of peri-implantitis. The morphology of the remaining peri-implant bone and the level of osseointegration, however, remain unknown. Our aim was to characterize advanced peri-implantitis bone defects in humans.

Methods

Four patients (3 female and 1 male) were diagnosed with peri-implantitis. A total of 5 implants with machined surfaces and a mean loading time of 12 ± 6 years were removed due to advanced bone loss. The defect extension, the peri-implant bone density (bone area per tissue area in percentage), bone-to-implant contact (%), and the number of filled and empty osteocyte lacunae were calculated based on undecalcified histological specimens.

Results

The defect extension was on average 4.2 mm (95% CI 0.8–3.4). Remaining peri-implant bone showed a high density of 85.5% (95% CI 79.1–91.3) and covered in total 74% (95% CI 70.5–77.5) of the implant surface. Filled and empty osteocyte lacunae density was on average 191 and 165/mm2 (95% CI 132–251; 103–225), respectively. Histology further revealed signs of ongoing bone formation and resorption.

Conclusion

There are signs that suggest that once the original cortical bone is lost due to peri-implantitis, the remaining apical trabecular bone is reinforced and transformed into cortical bone that might take over the functional load.
A matrix approach for stationary analysis fluid model driven by an M/M/1/N queue with discouraged arrivals
Authors: EL-paoumy Mahdy S. , Radwan Taha
Published: March 2020

In this paper, a fluid queue driven by truncated queue with discouraged arrivals is considered. Using the efficient matrix technique, the expressions of the steady-state distribution of both the buffer content and stationary state probabilities of background birth-death process are acquired. Then, performance measures and analysis of server utilization and mean buffer content are carried out.
A digital information system for cultural landscapes: the case of Slender West Lake scenic area in Yangzhou, China
Authors: Yang Chen , Han Feng
Published: March 2020

The rapid development of digital technologies provides important opportunities for more effective cultural heritage conservation and management. While the concept of cultural landscape has been accepted by the academic community in the cultural heritage field for many years, the digital conservation of cultural landscapes still lacks pragmatic guidance. The aim of this article is to explore an approach for building a digital information system to support cultural landscape conservation and management. The Slender West Lake scenic area, a typical cultural landscape in China, was used as an instrumental case study. A geo-database was designed and established to integrate the information of the natural, cultural, tangible and intangible landscape features of Slender West Lake. The digital information system for cultural landscapes provides a more holistic, dynamic and specific cultural perspective on heritage for landscape conservators. The system provides comprehensive information support for heritage conservation, management and interpretation, which are not achievable with conventional tools. This article has expanded the cultural heritage theory by presenting a practical guide for the digital information management of cultural landscapes. The workflow for building a cultural landscape geo-database can be used as a reference for heritage projects in China and other countries.
Harnessing digital workflows for the understanding, promotion and participation in the conservation of heritage sites by meeting both ethical and technical challenges
Authors: Santana Quintero Mario , Awad Reem , Barazzetti Luigi
Published: March 2020

The current application of digital workflows for the understanding, promotion and participation in the conservation of heritage sites involves several technical challenges and should be governed by serious ethical engagement. Recording consists of capturing (or mapping) the physical characteristics of character-defining elements that provide the significance of cultural heritage sites. Usually, the outcome of this work represents the cornerstone information serving for their conservation, whatever it uses actively for maintaining them or for ensuring a posterity record in case of destruction. The records produced could guide the decision-making process at different levels by property owners, site managers, public officials, and conservators around the world, as well as to present historical knowledge and values of these resources. Rigorous documentation may also serve a broader purpose: over time, it becomes the primary means by which scholars and the public apprehends a site that has since changed radically or disappeared. This contribution is aimed at providing an overview of the potential application and threats of technology utilised by a heritage recording professional by addressing the need to develop ethical principles that can improve the heritage recording practice at large.
Digital cultural heritage and rural landscapes: preserving the histories of landscape conservation in the United States
Authors: Karle Sarah , Carman Richard
Published: March 2020

This paper addresses how a digital heritage project can impact the research and interpretation of a large-scale rural cultural landscape in the United States. Due to the size and scope of rural landscapes, large-scale documentation methods are critical to advancing landscape conservation and preservation initiatives. Using an in-progress online project to document a 1935 US federally sponsored program, the Prairie States Forestry Project (PSFP), the authors show how diverse visual and textual data can be spatialised to construct a map reading of landscape change over time. To date, the PSFP is one of the largest afforestation projects in the history of the United States; the United States Forest Service and thousands of landowners undertook a series of cooperative planting agreements to plant over 200 million trees over seven years in approximately 33,000 shelterbelts from the panhandle of Texas to the North Dakota border. Due to a lack of coordinated monitoring, shelterbelt location and status was unknown, and the original archival material remained unpreserved. In the case of the Prairie States Forestry Project, the process for digitising and disseminating previously inaccessible primary source documents is an act of preservation that creates opportunities for future large-scale landscape conservation projects. The application of the archival mapping method and resulting PSFP datasets can be incorporated by individuals working on heritage documentation such as Historic American Landscapes Survey (HALS) reports, National Register nominations, or Cultural Landscape Reports for the National Parks Service. The dataset could also be used by private groups such as cooperative conservation land managers.
Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in Patients With Advanced Chondrosarcoma
Authors: Tap William D. , Villalobos Victor M. , Cote Gregory M. , Burris Howard , Janku Filip , Mir Olivier , Beeram Murali , Wagner Andrew J. , Jiang Liewen , Wu Bin , Choe Sung , Yen Katharine , Gliser Camelia , Fan Bin , Agresta Sam , Pandya Shuchi S. , Trent Jonathan C.
Published: March 2020

PURPOSE

Surgery is the primary therapy for localized chondrosarcoma; for locally advanced and/or metastatic disease, no known effective systemic therapy exists. Mutations in the isocitrate dehydrogenase 1/2 (IDH1/2) enzymes occur in up to 65% of chondrosarcomas, resulting in accumulation of the oncometabolite D-2-hydroxyglutarate (2-HG). Ivosidenib (AG-120) is a selective inhibitor of mutant IDH1 approved in the United States for specific cases of acute myeloid leukemia. We report outcomes of patients with advanced chondrosarcoma in an ongoing study exploring ivosidenib treatment.

PATIENTS AND METHODS

This phase I multicenter open-label dose-escalation and expansion study of ivosidenib monotherapy enrolled patients with mutant IDH1 advanced solid tumors, including chondrosarcoma. Ivosidenib was administered orally (100 mg twice daily to 1,200 mg once daily) in continuous 28-day cycles. Responses were assessed every other cycle using RECIST (version 1.1).

RESULTS

Twenty-one patients (escalation, n = 12; expansion, n = 9) with advanced chondrosarcoma received ivosidenib (women, n = 8; median age, 55 years; range, 30-88 years; 11 had received prior systemic therapy). Treatment-emergent adverse events (AEs) were mostly grade 1 or 2. Twelve patients experienced grade ≥ 3 AEs; only one event was judged treatment related (hypophosphatemia, n = 1). Plasma 2-HG levels decreased substantially in all patients (range, 14%-94.2%), to levels seen in healthy individuals. Median progression-free survival (PFS) was 5.6 months (95% CI, 1.9 to 7.4 months); the PFS rate at 6 months was 39.5%. Eleven (52%) of 21 patients experienced stable disease.

CONCLUSION

In patients with chondrosarcoma, ivosidenib showed minimal toxicity, substantial 2-HG reduction, and durable disease control. Future studies of ivosidenib monotherapy or rational combination approaches should be considered in patients with advanced mutant IDH1 chondrosarcoma.
Randomized, Phase II Study of Trastuzumab Beyond Progression in Patients With HER2-Positive Advanced Gastric or Gastroesophageal Junction Cancer: WJOG7112G (T-ACT Study)
Authors: Makiyama Akitaka , Sukawa Yasutaka , Kashiwada Tomomi , Kawada Junji , Hosokawa Ayumu , Horie Yoshiki , Tsuji Akihito , Moriwaki Toshikazu , Tanioka Hiroaki , Shinozaki Katsunori , Uchino Keita , Yasui Hirofumi , Tsukuda Hiroshi , Nishikawa Kazuhiro , Ishida Hiroyasu , Yamanaka Takeharu , Yamazaki Kentaro , Hironaka Shuichi , Esaki Taito , Boku Narikazu , Hyodo Ichinosuke , Muro Kei
Published: March 2020

PURPOSE

This study evaluated the continuous use of trastuzumab beyond progression (TBP) in human epidermal growth factor receptor 2 (HER2)-positive advanced gastric or gastroesophageal junction (G/GEJ) cancer.

PATIENTS AND METHODS

Patients with HER2-positive advanced G/GEJ cancer refractory to first-line chemotherapy with trastuzumab in combination with fluoropyrimidine and platinum were eligible. Patients were randomly assigned to the paclitaxel (80 mg/m2, days 1, 8, and 15, every 4 weeks) or paclitaxel with trastuzumab (PT; initially 8 mg/kg followed by 6 mg/kg, every 3 weeks) arms. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), response rate, and safety. Biomarkers such as HER2 expression status in tumor tissue after first-line treatment, HER2 amplification evaluated in serum cell-free DNA, and soluble HER2 levels were analyzed.

RESULTS

Overall, 91 patients were allocated to the paclitaxel (n = 46) and PT (n = 45) arms. The median PFS in the paclitaxel and PT arms was 3.2 and 3.7 months, respectively (hazard ratio [HR], 0.91; 80% CI, 0.67 to 1.22; P = .33), and the median OS in both arms was 10 months (HR, 1.2; 95% CI, 0.75 to 2.0; P = .20). The overall response rates in the paclitaxel and PT arms were 32% and 33%, respectively ( P = 1.00), and safety was comparable between the 2 arms. On exploratory analyses, HER2 positivity of tumor tissues was lost after first-line chemotherapy in 11 (69%) of 16 patients whose tumor tissues were available, and circulating HER2 DNA amplification was detected in 41 (60%) of 68 patients. However, no biomarkers associated with efficacy of TBP were found.

CONCLUSION

The TBP strategy failed to improve PFS in patients with HER2-positive advanced G/GEJ cancer, and no beneficial biomarkers were found.
Developmental psychology
Authors: Mandel' Boris
Published: March 2020

The manual is a unique course that includes a work program with modular technology. Each Chapter is accompanied by a list of key words for memorization and repetition, questions and tasks. The textbook also contains a list of required and additional literature, about the themes of the seminars and practical training, the approximate list of questions for self-study for exams and credits, the modular division of the.
Meets the requirements of Federal state educational standards of higher education of the last generation.
For students and teachers of pedagogical universities, psychologists, pediatricians, and for anyone interested in child psychology and psychology of development as an integral part of General psychology.
Accounting of Decisions of Executive Bodies in the Pre-Bank Period
Authors: Chaykovskaya L. , Mikheev M.
Published: March 2020

Th e article discusses issues related to the possible consequences of making managerial decisions, in which responsibility for certain actions of the executive body extends to employees of fi nancial and accounting services that carry out accounting support for such actions. The article reveals a confl ict of interest associated with management decisions on bonuses or with an increase in wages in the period preceding bankruptcy.
Financial Security Assessment Indicators of the Territories of Advanced Development of the Far East of Russia
Authors: Yakimova Vilena , Brizickaya A.
Published: March 2020

Th e article reveals the concept of financial security of priority development areas as structural elements of the regional economy of the Russian Far East, defi nes fi nancial security indicators necessary for financial monitoring of the efficient use of financial resources and development of measures to minimize the impact of fi nancial risks. Th e level of financial security of the territories of priority development created in the Far Eastern regions of Russia was assessed, and the main trends and fшnancial risks were identified.
Apulian Karst Springs: A Review
Authors: Liso I.S. , Parise M.
Published: March 2020

Apulia (southeastern Italy) is an elongated peninsula, located between the Ionian and the Adriatic seas, characterized by a semi-arid climate. It is an almost entirely karst region, with very limited availability of surface freshwater resources. The groundwater, the only water resource of Apulia, is affected by severe pollution problems related to both antropogenic and seawater intrusion phenomena. This is further exacerbated by the strong tourist vocation of the area, with heavy pressure by touristic water demand, especially during summertime. The Apulian geography and related freshwater problems require a thorough knowledge about karst processes, with specific regard to springs and aquifers. Despite this, in recent decades the attention on regional karst water resources was quite limited, and there is the huge need to implement new research in this field, aimed at reaching a better understanding of the Apulian karst. In this work we present a review on the main Apulian karst springs, divided in the three main sub-karst areas (Gargano, Murge, and Salento), based upon critical revision of the existing scientific literature. The aims are to build a database of known karst springs, and, further, to highlight the widespread and remarkable presence of karst phenomena in the region.
Cultures of volunteer care? A comparative study of Australia and Denmark
Authors: Overgaard Charlotte
Published: March 2020

This article seeks to understand two puzzling findings from a comparative study of volunteer care work: that volunteers in Denmark are perceived to be cost-adding, while volunteers in Australia are perceived to be cost-saving; and that volunteers in Australia are perceived to be better than paid workers, while volunteers in Denmark are considered second-best to paid workers. Using a ‘cultures of care’ framework, this article explores whether these articulations reflect on culturally determined care ideals. The findings suggest that different cultures of care exist. Differences are explained by the development of the two welfare states.
Fabrication of a mesoporous silica film based optical waveguide sensor for detection of small molecules
Authors: Wang Guiqiang , Sun Shuqing
Published: March 2020

In this paper, a thick mesoporous silica film (MSF) (more than 700 nm) was fabricated via the two-step enhancing Stöber solution growth approach (ESSGA). According to the optimization based on the transfer matrix method, a thicker MSF sensor has higher waveguide index sensitivity and is more suitable for the adsorbent detection, while a thinner MSF sensor has higher covered medium index sensitivity and is more appropriate for non-adsorbent detection. The covered medium index sensitivity and refractive index resolution of the fabricated MSF optical waveguide sensor were calculated to be 53.18 deg/RIU and

1.28

×

10

−
6

R
I
U

, respectively. For the detection of a small molecule, hexadecyltrimethylammonium bromide was used as a model of a small molecule to verify its sensing property and its limit of detection (LOD) as low as 1.879 nM was obtained. In order to detect heavy metal ions, the MSF was modified with an amino group by the post-grafted method. The response of the resonance angle shift is more sensitive to

P
b

2
+

ion than

C
u

2
+

ion and both their LODs could reach the nanomolar detection level; those are 17.30 and 6.44 nM, respectively.
Filter construction using Ronchi masks and Legendre polynomials to
analyze the noise in aberrations by applying the irradiance transport
equation
Authors: Arriaga Hernández J. A. , Cuevas Otahola B. T. , Oliveros J. , Jaramillo Núñez A. , Morín Castillo M.
Published: March 2020

We tested different optical elements placed in three different
positions by applying the irradiance transport equation (ITE),
obtaining the wavefront

[
W
(
x
,
y
)
]

and aberration surface
[

AS

(
r
,
θ
)

]. The existing noise in the captures

I

as well as in the

W

and

A
S

were analyzed applying several
filters: first a filter based on Legendre polynomials (LP), generating
the most probable points increasing the data resolution; second, a
filter based on a 50 deg 2D-LP was used as a multilineal fit (multiple
linear regression); and third, an ideal bandpass filter in the Fourier
space after inducing a periodicity using Ronchi simulated masks with
periods in

x
,
y
,
x
y

was used to perform data scanning
(similar to the four-step phase-shifting method). Signal-to-noise
ratio values were obtained for each proposed filter along with the
most probable image free from noise, determined from a linear
combination of the original data and the applied filters.
Aplicação do método AHP para confecção de modelo de favorabilidade hídrica subterrânea de aquíferos fraturados
Authors: Olivieira Nilcileia Cristina de Magalhães , Bacellar Luis De Almeida Prado , Fiume Bruna , Barella Cesar Falcão , Nola Iraydes Tálita de Sena
Published: March 2020

A locação de poços tubulares em aquíferos fraturados é complexa devido à dificuldade de se encontrar água nestes meios, de alta heterogeneidade e anisotropia. Há várias propostas metodológicas que têm como objetivo encontrar áreas mais favoráveis para a produção de água nestes aquíferos, que normalmente envolvem condicionantes geológicos e geomorfológicos. No presente trabalho, pretende-se definir um mapa de favorabilidade hídrica subterrânea para uma área a norte do Quadrilátero Ferrífero (MG) por meio da integração dos mapas litológico, de declividade, HAND (Height Above the Nearest Drainage) e densidade de lineamentos morfoestruturais, magnetométricos e radiométricos. Para tal, adotou-se o método AHP (Analytic Hierarchy Process), que possibilita a integração de vários planos de informação de forma menos subjetiva. O mapa de favorabilidade, validado com dados de capacidade específica de 361 poços tubulares, mostrou que os fatores condicionantes mais relevantes são em ordem decrescente, o HAND, declividade, densidade de lineamentos e litologia. Com os resultados, criou-se um modelo de favorabilidade hídrica subterrânea para a área de estudo, que poderá ser utilizado em outras regiões similares.
Cyberspace : Ruang Publik Baru bagi Aktivitas Politik Muhammadiyah
Authors: Sholikin Ahmad
Published: March 2020

The presence of various political movements lately indicates a new appearance in the Indonesian middle class. Muhammadiyah in various previous studies has always been associated with the sociological class of the Indonesian middle class. Analysis of the middle class is always placed as "relaxed class" or "spoiled class". However, in recent cases, the class has transformed itself into a strong actor from the extra-parliamentary political arena that is able to influence political succession. The use of social media then becomes important in encouraging middle class political awareness to be an effective partisan class. This article uses the perspective of cyberactivism to elaborate more deeply on the potential of Muhammadiyah's political activism in the 2019 political year.
PENGEMBANGAN MODEL E–DEMOKRASI LOKAL MELALUI RADIO (Studi Pada Program Lang-lang Kota Radio Mayangkara FM)
Authors: Huda Anam Miftakhul
Published: March 2020

The new model of developing electronic democracy through e-democracy makes local democracy very dynamic. The level of public trust in radio is very high with an indicator of the number of community members who voluntarily inform all incidents in Blitar City and Regency. This new concept in the framework of radio journalism is referred to as citizen journalism. This study intends to develop a tripartite model of local democracy between the information giver (complainant), the handling agency (the agency complained) and the media (radio) as a bridge in solving the problem. So far the research method used is using qualitative methods with emphasis on participatory aspects. Radio owners, program directors, reporters and listeners who complain are the core informants in this study. The sampling technique used was purposive sampling using data or source triangulation and theory triangulation as a test tool. The results of this study are in the form of the city langlang program as a forum for public discussion on air in the form of complainants reporting their problems to the radio through sms, telephone, e-mail and social media. The model developed is not only on air but also off water, so that complainants can communicate with related parties via the Mayangkara FM radio bridge.
HYPER REALITAS SIMULAKRA TAGAR #2019GANTIPRESIDEN DALAM PEMILIHAN PRESIDEN INDONESIA 2019
Authors: Fadillah Dani
Published: March 2020

This paper is aim to describe how a hashtag appearing in the dynamics of communication on social media is capable of creating a very massive mass movement in the real world. As well as troublesome rulers and authorities to set it up Because it considered a political charge that is in the hashtag could potentially provide a surge of turmoil that is great for the holder of the status quo of the political power of the homeland. By the election of the President of the Republic of Indonesia 2019 was presented with a viral hashtag on social media, the hashtags that were first administered twitted by prosperous Justice Party (Partai Keadilan Sejahtera) politician Mardani Ali Sera, raised the spirit of the masses The number is not minimal not to elect the general election which took place in April 2019. Even until the polls have done, the hashtag still has strong political magic to unite the opposition forces because the reunited was elected to become President of the Republic of Indonesia until 2022. This paper contains the results of qualitative research by making the idea of Jean Baudrillad about Simulacra, simulation, and artificial Phenomenon as his analysis knife. Here the author collects various literary sources in the different news media coverage of the hashtag #2019GantiPresiden then conduct a study of the messages that have a variety of information given to the hashtag Using the turbulent analytical knife of Jean Baudrillad above. Finally, the conclusion of this paper is necessary to fight massive efforts to resist the enormous surge of hashtags #2019GantiPresiden in the homeland in a variety of ways so that the focus is not more significant and to discuss the interests of Political authorities.
Innovación teórica para analizar el proceso de inclusión estudiantil desde la práctica pedagógica
Authors: Royo Peña Hedni Patricia , Salazar Caballero Yolenis Del Carmen , Rada Tovar Amalfi Del Rosario , Petit Torres Elsa Emilia
Published: March 2020

Este artículo contiene un enfoque teórico para fortalecer la trayectoria científica en el área de estudio del proceso de inclusión estudiantil en el marco de la práctica pedagógica y las competencias docentes que en él influyen. En el contexto específico de la Institución Educativa Técnica Departamental Juana Arias de Benavides de Plato (Magdalena) se efectuó una investigación documentada con aplicación de técnicas de revisión sistemática de literatura especializada y análisis de contenidos, se construyó un flujograma teórico que permitió operacionalizar y presentar de forma innovadora: 1) La correspondencia conceptual entre práctica pedagógica, competencia docente, competencia inclusiva, práctica docente y docencia inclusiva. 2) La diferenciación conceptual entre inclusión educativa y educación inclusiva. Se concluye con un inventario de todas las unidades de análisis asociadas al tratamiento de los factores influyentes en la construcción de lineamientos pedagógicos que permiten fortalecer el proceso de inclusión estudiantil.
Virtual conferences in higher education: Teasing out their transformative potential for sustainable development
Authors: Mader Clemens , Zimmermann Anne B. , Diethart Mario , Mulà Ingrid
Published: March 2020

The Coronavirus outbreak has made virtual education a high necessity. Our intention here was to highlight potentials of virtual conferences to enhance transformative learning for sustainable development; new applications will provide powerful insights.
Science policy recommendations for funding real-world laboratories and comparable formats
Authors: Defila Rico , Di Giulio Antonietta
Published: March 2020

Dealing with a research format that is both transformative and transdisciplinary remains a challenge, also for funders. Based on insights gained from accompanying 14 projects running as real-world laboratories in Baden-Württemberg from 2015 to 2019 ‐ the so-called BaWü
Labs, ten recommendations are proposed for funders.