bluuebunny/crossref_metadata_2025 huggingface dataset:
Alterations in methylation and SNPs of OPRM1 gene show lack of association with heroin (nyaope) consumption in South African males of African ancestry
Authors: Daniels William , Masiangwako Tsholofelo , Morgan Nirvana , Manilall Ashmeetha
Published: August 2024

Nyaope is a highly addictive heroin derivative that elicits its effects via the -opioid receptor. Gene mutations and (cytosine-phospho-guanosine) CpG methylation, alter the function of the -opioid receptor gene (OPRM1) and protein. The single nucleotide polymorphisms (SNPs) rs1799971 (118 A>G) and intronic rs3778150 (T>C) in the OPRM1 have previously been associated with heroin use. The SNP rs1799971 can influence methylation levels of OPRM1 and alter mRNA and protein expression. This study compared the degree of OPRM1 methylation and allele frequency of SNPs rs1799971 and rs3778150 in black South African male nyaope users (n=200) to age-and gender-matched controls (n=55).DNA was extracted from whole blood samples, and analysed by methylation-specific PCR and sequencing to determine methylation frequencies across 29 CpGs within the OPRM1promoter gene region. SNPsrs1799971 (118 A>G) and rs3778150 (T>C) were assessed using SNP genotyping Taqman assays.Using a positive methylation assignment method, most CpGs were significantly more unmethylated in nyaope users than in controls. Using a partial methylation assignment method, most CpGs displayed significantly higher percentages of partial methylation in nyaope users than in controls. The AG genotype frequency for SNP (118 A>G), was higher in controls than in nyaope users while other genotypes (AA & GG) for SNP rs1799971 and (TT, CT, CC) SNP rs3778150 were broadly similar in both groups. There was no correlation observed between nyaope consumption and the presence of SNP rs1799971 and/or rs3778150 in the study populations.This study provided evidence that methylation may not be associated with the intake of nyaope and that SNPs rs1799971 and rs3778150 did not alter the methylation status of the OPRM1 promoter gene or contribute to nyaope addiction in a black South African male population.
The potential role of CAR-T in Multiple Myeloma Treatment. A review
Authors: Kostelecka Katarzyna , Bryliński Łukasz , Woliński Filip , Smyk Miłosz , Biłogras Jan , Baj Jacek
Published: August 2024

Background: Multiple myeloma (MM) is a hematologic malignancy, which causes accumulation of plasma cells in the bone marrow. The symptoms of MM are associated with organ dysfunction and include hypercalcemia, renal failure, anaemia and bone destruction. A relatively new and promising therapeutic option for MM is CAR-T therapy. Aim of the study: The study aimed to outline the role of CAR-T therapy in MM treatment.Material and methods: We conducted a literature review containing 24 articles. We described the role of CAR-T in MM therapy, its therapeutic points, the effectiveness of therapy, and its side effects.Results: CAR-T cells transduced with CAR can recognize specific antigens and kill the cancer cells. For MM these specific antigens are integrin β7, SLAMF7, CD138, BCMA, GPRC5D and FCRL5. Integrin β7 in its active form, can be found in MM cells, whereas in other blood cells, integrin β7 is in the inactive form. The expression of SLAMF7 on MM cells is high and uniform, but its function is not clear: expression of SLAMF7 in MM is suspected to increase the survival and adhesion of MM cells to bone marrow stromal cells. CD138's strong expression on MM cells is contributing to their development and proliferation. BCMA expression was not detected in other human tissues, only in MM cells. GPRC5D is highly expressed in bone marrow samples from MM patients, and minimally expressed in other hematologic malignancies. FCRL5 is a protein marker found specifically on plasma cells in MM, its increased expression promotes B cell proliferation. The AlloCAR-T therapy also seems to be an effective method.CAR-T therapy has also adverse effects including cytokine release syndrome, neurological toxicity, haematological disorders and infusion fever. Conclusions: The effects of CAR-T therapy in MM are really promising and give real benefits to patients. For this reason, it should be further developed and subjected to further research.
Productive and reproductive performance of cattle in the tropical part of India
Authors: C SUMI PRINCESS , KUMAR DINESH , SARAN SANDEEP , KUMAR SANJAY , SHARMA RUCHI , JUNIWAL CHITRA , P THAMIZHAN , NISHANTH J MARIA ANTO DANI , D DINESH
Published: August 2024

The assessment of productive and reproductive traits helps in identifying animals with superior germplasm in comparison to their population mean which helps in selecting animals for breeding purposes. The early detection of low- performing animals based on the parameters considered for the evaluation of productive and reproductive traits in the study can help in culling animals at an early age, thus saving the cost of maintenance or losses for dairy farmers. Overall, it was observed that the productive and reproductive performance of cross-bred cows was better as compared to the buffaloes and non-descript cows. Therefore, the study advises taking the following steps; record keeping, regular testing for various diseases, balanced ration, maintenance of proper hygiene, availability of nearby veterinary services, and upgradation of non- descript animals to exploit maximum production potential at farmers’ level.
COMPARATIVE STUDY OF MULTI CRITERIA DECISION MAKING METHODS IN A CASE STUDY OF THE BEST EMPLOYEE DECISION SUPPORT SYSTEMS
Authors: Istini Syalis Ibnih Melati , Ahmad Apandi  , Rama Dian Syah
Published: August 2024

Selecting the best employees is an alternative for companies to maintain and improve the quality of employee work. Being best employee is a matter of pride for every employee, so this good thing will also have an impact on the company. Having employees with good quality will certainly improve the quality of the company itself. Making decisions for the best employees is a challenge for companies because its subjective nature makes the selection inaccurate, so an objective decision-making system is needed according to the criteria. The purpose of this study is to compare three multi-criteria decision-making methods (MCDM) namely AHP (Analysis Hierarchy Process), SAW (Simple Additive Weighting Model) and TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution). Based on comparative studies from several journals, the results of the accuracy levels obtained from different methods show that there are different results from several cases discussed in reference journals, this is due to differences in the number of criteria and alternatives used for analysis.
PERBANDINGAN HARGA POKOK PRODUKSI DENGAN METODE FULL COSTING DAN VARIABEL COSTING PADA UKM BAKSO WONOGIRI WARUNG BONGKOK
Authors: Handayani Nicky , Wijaya Irmawati , Meilani Laura
Published: August 2024

Tujuan penulisan untuk mengetahui dan menganalisis perhitungan harga pokok produksi pada UKM Bakso Wonogiri Warung Bongkok dengan metode full costing dan variabel costing. Penelitian ini menggunakan data Kuantitatif dengan menggunakan data Primer dengan meninjau langsung ke objek penelitian yaitu UKM Bakso Wonogiri Warung Bongkok dengan melalui wawancara,observasi dengan pihak terait dan dokumentasi. Dari Penulisan Ilmiah ini dapat di ambil kesimpulan bahwa diketahui selisih harga pokok produksi menurut UKM bakso sebesar Rp 16.783 sedangkan harga pokok produksi dengan metode full costing sebesar Rp 18.054 , dan harga pokok produksi yang dihasilkan menggunakan metode variable costing sebesar Rp 17.956 . Selisih harga pokok produksi menurut UKM dengan metode full costing sebesar Rp 1.271 sedangkan selisih harga pokok produsi menurut UKM dengan metode variable costing sebesar Rp. 1.173 , dari perhitungan di atas menunjukkan bahwa perhitungan menggunakan metode full costing menghasilkan harga pokok produksi yang lebih besar dibandingkan perhitungan menggunakan metode full costing
Understanding the forces shaping African urbanisation
Authors:   University College, London (UCL), Robinson Jennifer
Published: August 2024

Many calls have been made for international investment in Africa to be directed towards urban development projects. Researchers in the Making Africa Urban project are looking into the different transnational processes that are shaping the future of African cities, and the wide range of actors who are involved, as Professor Jennifer Robinson explains.
Return of the Otter
Authors:   NORCE, Kambestad Marius , Keller Rose ,   Norwegian Institute for Nature Research:
Published: August 2024

Native populations of Eurasian otters compete with humans for resources, in particular Atlantic salmon, which is now on Norway’s red list of threatened species. We spoke to Dr Marius Kambestad and Dr Rose Keller about their work in investigating the nature of the humanotter conflict, which could then lead to more effective strategies to manage otter populations.
Modern techniques to analyse ancient terraces
Authors:   University of Tromsø Museum, Brown Antony , Fallu Daniel
Published: August 2024

Researchers in the TerrACE project are using a variety of modern techniques to look at agricultural terraces in different locations across Europe, aiming to build a deeper picture of why they were initially created and what crops have been grown there at different periods, as Professor Antony Brown and Dr Daniel Fallu explain.
KEPERCAYAAN (TRUST) PADA ANGGOTA KOMUNITAS PEREMPUAN NELAYAN DI DESA LAMBANGI KECAMATAN KOLONO TIMUR KABUPATEN KONAWE SELATAN
Authors: Nasyratullah Fadillah , Abdullah Sukmawati , Salahuddin Salahuddin
Published: August 2024

One element of social capital that plays an important role in community resilience is trust. When community members trust each other, they are better able to weather crises and adapt to unexpected changes. Therefore, trust within a community must be maintained in order to overcome various challenges that may arise, including economic vulnerability. This study aims to assess the level of trust in members of the fisherwomen community in Lambangi Village, East Kolono Sub-district, South Konawe Regency. The study population consisted of all female fish processors of anchovies, with a total of 32 individuals. The sample determination employed the saturated sampling technique or census, whereby the entire population was taken as a sample, namely 32 people. Data were collected through interviews, surveys, and documentation, with the assistance of questionnaires. This study employed a quantitative approach in its completion. Data were processed using descriptive quantitative analysis through the use of the class interval formula. The findings indicated that the level of trust among the fisherwomen community members in Lambangi Village was high. This suggests that the fisherwomen have effectively implemented every aspect of trust, namely aspects of openness, sharing, acceptance, support, and cooperation within the community of fisherwomen in Lambangi Village.
ANALISIS KETAHANAN PANGAN RUMAH TANGGA PETANI PADI SAWAH DI DESA MONAPA KECAMATAN MOWILA KABUPATEN KONAWE SELATAN
Authors: Ariyani Ni Ketut Hintan , Rosmawaty Rosmawaty , Zani Munirwan
Published: August 2024

This study aims to find out (1) How is the food security of paddy rice farming households in Monapa Village, Mowila District, South Konawe Regency; (2) Factors affecting the food security of rice farming households in Monapa Village, Mowila District, South Konawe Regency, with a total sample of 63 respondents using the slovin formula. To answer the first goal using the measurement of the share of food expenditure. For the second purpose using multiple linear analysis. Based on the results of research on the food security of lowland rice farmer households in Monapa Village, Mowila District, South Konawe Regency, the majority of 65.08% of households fall into the food insecure category (share of food expenditure ≥ 60%) and the remaining 34.92% of households included in the category of food security (share of food expenditure ≤ 60%). The factor that has a significant effect on the food security of paddy rice farming households in Monapa Village, Mowila District, South Konawe Regency is household income with a significant value of 0.032 which is less than the value of α (0.05). While the variables of the number of family members, the education of the housewife, the price of rice and eggs have no significant effect on the food security of rice farming households.
PERAN PENYULUH PERTANIAN TERHADAP KINERJA USAHATANI PADI SAWAH DI DESA TEPPOE KECAMATAN POLEANG TIMUR KABUPATEN BOMBANA
Authors: Bahtiar Bahtiar , Salahuddin Salahuddin , Jayadisastra Yoenita
Published: August 2024

This study aims to examine the role of agricultural extension workers in the context of wet-rice farming in Teppoe Village, East Poleang Subdistrict, and to elucidate the relationship between the two. The research population consisted of all wet-rice farmers in Teppoe Village, amounting to a total of 250 individuals. A sample of 25 individuals was selected from the total research population, representing 10% of the total number of respondents. The data were collected via survey, interview, and documentation methods with the assistance of research instruments in the form of questionnaires. This study employs a quantitative approach. The research data were analyzed using quantitative descriptive methods, specifically the class interval formula and Spearman's rank correlation. The findings indicated that the role of agricultural extension workers in Teppoe Village, East Poleang Subdistrict, as facilitators was deemed to be satisfactory. However, their roles as motivators and educators were perceived to be inadequate, while their role as innovators was considered to be satisfactory. The performance of paddy rice farming in terms of productivity is in the satisfied category, while the sales price of paddy rice and farmers' income are in the moderately satisfied category. The relationship between the role of agricultural extension officers and farm performance was found to be statistically significant (value 0.031), though the strength of the relationship was relatively weak (value 0.363).
Relationship between serum metabolic indexes and immune function in patients with insomnia and their mechanism
Authors:   Department of Neurology, Taiyuan Central Hospital, Shanxi Province, 030009 PR China, Sumei Zhang
Published: August 2024

We conducted a study to examine how certain serum metabolic markers (reactive oxygen species (ROS), homocysteine (Hcy), and reduced glutathione (GSH)) impact the levels of IL-4 in patients with insomnia. The study involved 60 insomnia patients, including 20 with primary insomnia and 20 with somatopathy insomnia, aged 23-84 years with a mean age of 61.20 ± 12.59 years and a mean disease duration of 6.97 ± 8.45 years. There were 20 normal controls, 11 males and 9 females, aged 26-63 years, with an average age of 49.95 ± 10.52 years. We measured ROS levels using immunofluorescence, Hcy levels using enzyme-linked immunosorbent assay, and GSH levels using ELISA. The IL-4 level in serum was also detected by ELISA to assess the patient's immune function. Our analysis revealed that changes in ROS, Hcy, and GSH levels were associated with changes in IL-4 levels in serum. Therefore, early detection of serum metabolic changes in insomnia patients and proactive intervention can help reduce susceptibility to various infections and tumors.
Inteligência Artificial OpenAI Chat-GPT-3.5® comparada ao método tradicional para construção de Histórias na saúde
Authors: Silva Giovani Basso da , Souza Lucas Paulo de , Medeiros João Gabriel Toledo , Pellanda Lucia Campos
Published: August 2024

Objetivo: desenvolver e comparar histórias em quadrinhos sobre depressão na infância pelo método tradicional e pelo uso de Inteligência Artificial. Método:  Trata-se de um estudo metodológico no qual foram comparadas duas formas de produzir conteúdo para Histórias em quadrinhos:  a construção de histórias em quadrinhos de forma tradicional e a construção de histórias em quadrinhos através do uso de inteligência artificial. A etapa de validação e disponibilização do material ocorreram da mesma forma para os dois formatos de produção de conteúdo. Resultado:  Ambos os métodos deram origem a um personagem principal e seis personagens coadjuvantes, porém o método tradicional possibilitou a realização de 16 quadros de história e o método por inteligência artificial 8 quadros de história. Idealizou-se que as histórias em quadrinhos acontecessem em 3 momentos distintos. A apresentação do personagem, a ajuda e a terapia. Conclusão: As histórias em quadrinhos são uma das várias formas de cuidado em saúde. A utilização de recursos como esse permite uma aproximação entre profissional-paciente-família, o que pode auxiliar no tratamento e garantir que efeitos indesejáveis diminuam. A construção do material pelas duas formas foi satisfatória e propiciou um olhar no que diz respeito ao uso da inteligência artificial na área da saúde. Um fator limitante é a capacidade de geração de imagens através de textos, até o momento da publicação deste artigo, as plataformas de inteligência artificial não geram imagens através de grandes textos, tendo como limitação e necessidade a ilustração por pesquisadores humanos.
Perfil epidemiológico de gestantes de 35 a 49 anos, durante o período de 2010 a 2020, em Ribeirão Preto (SP)
Authors: Bot Bonfim Maria Carolina , Ferraz Talita Thereza , Fumes Isabela Cristina Machado , Grisolia Lívia Carvalho , Gomes Eloisa Jardim , Santos Daniele Cristina Pereira dos , Lopes Rafaela , Alves Rodolfo Oliveira , Marcella Caixeta Tavares  , Júlio Cesar  Zayas Cansino  , Narima Caldana  , Licerio Miguel
Published: August 2024

Resumo:  Introdução: Nos últimos anos a gravidez tardia tem se configurado como um fenômeno mundial e, embora os índices de nascimento estejam decrescendo, a média da idade materna tem aumentado constantemente. Dessa forma, há maior risco materno e perinatal naquelas mulheres que engravidam tardiamente. Objetivo: analisar o perfil epidemiológico, e informações sobre o parto de gestantes, com faixa etária entre 35 a 49 anos, durante o período de 2010 a 2020, em Ribeirão Preto- (SP).  Metodologia: Foi realizada coleta de dados no Datasus, por meio do Tabnet- SISVAN do perfil epidemiológico das gestantes de 35 a 49 anos e as informações sobre os partos destas durante o período de 2010 a 2020, em Ribeirão Preto-SP.  Resultados: As gestantes analisadas, foram 16.030, e representam 17,53% do total de gestantes no mesmo período em Ribeirão Preto- SP. Em relação ao perfil de gestantes com idade entre 35 e 49 anos, 12.670 ( 79,03%) se consideravam brancas. Em relação ao estado civil, 9.738 ( 60,75%) eram casadas. Acerca do acompanhamento durante a gestação, 9.530 ( 59%) realizaram pré-natal de forma mais  que adequada. Em relação à escolaridade, possuem 12 anos ou mais de estudos 7.512 gestantes (46,8%). Conclusão: A partir dos dados obtidos, conclui-se que houve um elevado índice de gravidez entre mulheres com idade entre 35 anos a 49 anos, de 2010 a 2020. A grande maioria das gestantes analisadas, 10.269  realizaram um pré-natal, intermediário, adequado, ou mais que adequado ( 64% do número total), favorecendo o bom desfecho da gravidez, para a mãe e bebê.
Palavras- chaves
Idade materna; gravidez de alto risco;  nível educacional da mãe.
Análise comparativa da evolução completude dos dados de coqueluche nas cinco regiões brasileiras: período 2007-2020
Authors: Geraldo Emanuelly Cácio , Reis Lorrane Janaina , Muniz Yasmim Emili , Masella Tania Aparecida Cancian , Zini Monica Magalhães Costa , Angelotti Lucila Costa Zini
Published: August 2024

A coqueluche, uma doença infecciosa que acomete o sistema respiratório, é a quinta maior causa de mortalidade por doenças imunopreveníveis em crianças menores de cinco anos. O objetivo desse estudo foi comparar a evolução temporal da completude dos dados dos casos da doença notificados no Sinan, nas cinco regiões brasileiras, entre 2007 e 2020. No período analisado, a doença acometeu mais frequentemente pessoas do sexo feminino, brancas e com menos de 5 anos. A maior parte dos casos evoluiu para a cura. A completude dos dados de zona de residência, faixa etária, faixa etária menor que um ano, sexo, gestante e critério de confirmação se manteve entre excelente e muito boa em todas as regiões. Os dados de raça/cor mantiveram completude muito boa a excelente nas regiões Norte e Sul, oscilando entre regular e ruim nas demais regiões, algo prejudicial à compreensão de fatores demográficos de risco para o adoecimento. A evolução dos casos teve completude muito boa a excelente no Sul, Sudeste e Nordeste, regular a ruim no Centro-oeste e muito boa a ruim no Norte, fato desfavorável ao cálculo das taxas de cura e óbito. Apesar da boa completude na maior parte das variáveis demográficas no período, destaca-se a importância da melhoria da qualidade dos registros nas regiões Norte, Nordeste e Centro-oeste, que apresentaram completudes de dados essenciais mais baixas, indicando a necessidade de maior atenção dos gestores e de preparo dos profissionais de saúde para a realização dos registros de modo adequado e eficaz.
Monteverdia ilicifolia (espinheira-santa): uma breve revisão e relato de uma experiência de uso
Authors: Silva Telma Regina Ramos , Sales Débora Simone , Carmona Fábio
Published: August 2024

O consumo de fitoterápicos é secular entre as populações para alívio de dores, cura de doenças e controle de pragas. No Brasil, o Programa Nacional de Plantas Medicinais e Fitoterápicos tem por objetivo, entre outros, garantir acesso seguro e uso racional de plantas medicinais e fitoterápicos. A espécie vegetal Monteverdia ilicifolia (Mart. ex Reissek) Biral (Celastraceae), conhecida popularmente como espinheira-santa, destaca-se no tratamento de gastrite e úlcera péptica. O objetivo deste estudo é fazer uma revisão narrativa da literatura sobre esta espécie utilizando bases de dados online do Ministério da Saúde do Brasil, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO), Public Medline or Publisher Medline (PubMed) e ScienceDirect. As buscas foram realizadas sem espaço temporal específico utilizando as palavras Maytenus ilicifolia (nomenclatura anterior da planta) e gastrite. Foram incluídos artigos de revisão botânica, estudos etnobotânicos, pesquisas não-clínicas in vivo e in vitro e clínicas com seres humanos, e excluídos artigos sobre outra espécie de Monteverdia, biotecnologia, biodiversidade e bioeconomia, fitoquímicos, legislação e levantamentos etnobotânicos sobre múltiplas plantas. Foi possível verificar que existem mais estudos in vitro, em animais e etnobotânicos do que ensaios clínicos com seres humanos e todos contribuem corroborando a ação gastroprotetora da espinheira-santa. Tal ação está relacionada aos metabólitos polifenois, esteroides e triterpenos pelo mecanismo de ação semelhante aos medicamentos sintéticos sem efeitos colaterais. Conclui-se esta planta tem potencial para o tratamento de pacientes com gastrite e úlcera péptica, embora mais estudos em seres humanos sejam necessários.
Potenciais e desafios do trabalho interprofissional em programas de pós-graduação: uma revisão narrativa
Authors: Damasceno Ana Clarissa Lopes Silva , Tambone Lílian Bello Rocha , Martinez Bruno Prata
Published: August 2024

A integração entre os saberes com a horizontalização das especialidades reflete diretamente na qualidade do cuidado, possibilitando o atendimento mais integral e de acordo com as necessidades do usuário. O presente estudo teve por objetivo identificar potenciais e desafios para o trabalho interprofissional em estudos realizados com alunos e egressos de pós- graduações no Brasil, com base em uma revisão narrativa realizada em três bases de dados. A residência multiprofissional, enquanto formação, é um potencial para o desenvolvimento da interprofissionalidade nos serviços, no entanto o programa de residência é considerado um desafio, quando propõe a prática colaborativa através das modificações nos processos de trabalho. O modelo biomédico é considerado um obstáculo para o desenvolvimento da prática colaborativa nos serviços, assim como resistências a interdisciplinaridade e ao trabalho interprofissional. A educação interprofissionalizante adotada pelas instituições de modo continuo é considerada como um potencial para receptividade e desenvolvimento do modelo de trabalho baseado na prática colaborativa.
Relationship Between Age and Education of Women of Fertile Age with Participation in Long-Term Contraceptive Methods
Authors: Amin Erna , Hayuning Tiyas Ajeng , Anwar Yulianti , S Suryanti , Anita Nur
Published: August 2024

Objective: The aim of this research is to determine the relationship between age and education and the decision of women of childbearing age (WUS) to become MKJP family planning acceptors in Mamuju District.
Method: This research is quantitative research with a cross-sectional method. Data collection techniques include questionnaires. The data analysis used was univariate analysis and bivariate analysis with the chi square statistical test.
Result: The results of research based on the Chi Square Test show that there is a relationship between age (p value = 0.050) and education (p value = 0.017) and MKJP family planning participation.
Conclusion: The results of this study explain that there is a relationship between age, education, and WUS participation in family planning programs using long-term contraceptive methods.
PREVALENCIA DE INTOXICACIONES POR ORGANOFOSFORADOS Y CARBAMATOS EN EL CENTRO DE SALUD SANTA MARÍA MADRE DE DIOS DEL MUNICIPIO DE VILLA CHARCAS – CHUQUISACA- BOLIVIA 2018 – 2022
Authors: Mayorga Flores Paola Iveth , Rojas Collazos Gabriel , Delgadillo Urmilla Dimar Fernando , Rosas Diaz Lizeth Ninoska , Yucra Cano Betty Rosalba
Published: August 2024

ntroducción: Los plaguicidas más importantes y de uso frecuente son organofosforados y carbamatos, un grupo de sustancias orgánicas utilizadas sobre todo en la agricultura. Encontrarse al alcance, han sido empleadas en intentos suicidas. El objetivo de esta investigación fue determinar la prevalencia de intoxicaciones por organofosforados y carbamatos en el Municipio de Villa Charcas y la identificación de factores de riesgo psicosociales.
Material y Métodos: Estudio con enfoque cuantitativo, de tipo descriptivo, retrospectivo, se realizó la revisión historias clínicas de pacientes intoxicados de los últimos 5 años.
Resultados: Los resultados determinaron una prevalencia de 0,74 casos por cada 100 pacientes atendidos en el Centro de Salud Santa María Madre de Dios, de predominio, sexo femenino, edad de 20 a 39 años, solteros, grado de instrucción secundaria, ocupación labores del hogar. En su mayoría son intentos de suicidio causados por problemas familiares y/o sentimentales, presentando depresión, tristeza e inestabilidad afectiva antes del hecho y sin antecedentes de intentos previos, la mayoría no se encontraban bajo influencia de alcohol, generalmente se utilizó rodenticida por vía oral, dentro de su hogar, en horas del día. El tiempo transcurrido desde la ingesta hasta la atención en emergencia fue inespecífico, las intoxicaciones agudas presentaron el síndrome muscarínico, en pocos casos se indicó interconsulta con psicología.
Conclusiones: Se debe proporcionar capacitación al personal de Salud en la atención de pacientes con intoxicación, además de implementación de promoción y prevención desde una perspectiva de salud mental en los grupos más vulnerables.
PRESENTACION DE CASO: SARCOMA DEL ESTROMA ENDOMETRIAL: PRESENTACION INUSUAL. SERVICIO DE ANATOMIA PATOLOGICA HOSPITAL J. M. PENNA BUENOS AIRES – ARGENTINA. MAYO 2021
Authors: Becerra Coronado Mariane Daniela , Valverde Gamarra Daniela Susana
Published: August 2024

El SARCOMA DEL ESTROMA ENDOMETRIAL (SEE) es un tumor mesenquimatoso infiltrante maligno que surge del cuerpo uterino, el cuello uterino, la vagina y el ovario. Según sus características morfológicas a la microscopia, se clasifica como sarcoma estromal de bajo grado o indiferenciado (alto grado).
Su presentación habitual clínica y radiológica es como masa endometrial o miometrial, en su mayoría sólida, lesiones intramiometriales nodulares pero que puede mostrar degeneración quística que es muy inusual.
Este articulo presentamos el caso clínico (mayo, 2021) de una paciente de 41 años de edad que consulta porhipermenorreade2añosde evolución, realizandose los exámenes complementarios pertinentes, por lo cual se le realiza una histerectomía y salpingooforectomía bilateral remitido al servicio de patología, en el cual se observa una formación quística, que al estudio microscopico e inmunohistoquimico se diagnostica como Sarcoma del Estroma Endometrial de bajo grado.
Comparative Analysis of Peroxidase and Catalase Isoenzymes via Native-PAGE Electrophoresis and SDS-PAGE Profiling of Leaf Proteins in Rice Varieties under Infection Stress
Authors: Yadav Vinay Kumar , Khan N.A. , Yadav Bavita , Rathore Madhurjit Singh
Published: August 2024

Rice (Oryza sativa L.) is a staple food for over half of the world's population. However, rice productivity is significantly hindered by various diseases, including sheath blight caused by Rhizoctonia solani. This study aims to evaluate the resistance of different rice varieties and wild rice accessions to sheath blight and to analyze the biochemical responses, specifically peroxidase and catalase activities, under infection stress. The results revealed that Kalanamak and Pusa Basmati were highly susceptible, with high disease indices and visual ratings. Conversely, wild rice accessions such as O. rufipogon and O. australiensis exhibited lower disease indices, indicating moderate resistance. Peroxidase activity varied significantly among the rice leaves, ranging from 148.83 to 182.44 mg/g fresh weight/min. Dhanya 748 showed the highest peroxidase activity, followed by O. australiensis and O. rufipogon. Native-PAGE electrophoresis of peroxidase isoenzymes demonstrated high-intensity bands in O. rufipogon, BPT 5204, and Swarna Sub-1, while minimal or no bands were observed in other genotypes, indicating varying levels of peroxidase activity. Catalase activity also showed significant variation, ranging from 138.18 to 152.14 mg/g fresh weight/min. BPT-5204 exhibited the highest catalase activity, followed by O. australiensis and Pusa Basmati. Isoenzyme analysis via Native-PAGE revealed high-intensity catalase bands in O. australiensis, Dhanya 748, NDR 118, and Pusa Basmati, while no bands were observed in O. rufipogon, CSR 13, Arize 6444, and Swarna Sub-1. SDS-PAGE analysis of leaf proteins showed variability in banding patterns. Non-infected leaves of Swarna Sub-1, Arize 6444, Kalanamak, and Pusa Basmati had minimal bands, while O. australiensis and Dhanya 748 showed maximum bands. Infected leaves of CSR 13, NDR 118, Arize 6444, Kalanamak, Dhanya 748, and Pusa Basmati had minimal bands, whereas O. australiensis exhibited maximum bands. Overall, the study highlights the potential of wild rice species in enhancing disease resistance and provides insights into the biochemical responses of rice varieties under pathogen stress.
Grammar Study of Korean Historical Video Content for Foreign Korean Language Learners: Focusing on the Usage Patterns of Sentence-Final Endings
Authors:   K-Culture·Story Contents Research Institute, Sim Hyun-Bo , Lee Jung-Hee
Published: August 2024

This study proposes an approach to engaging foreign learners of Korean with Korean history, which can be somewhat heavy and challenging, by treating it as 'history consumption.' To provide learning materials that aid foreign learners of Korean in watching Korean historical video content, the study compiled a corpus of dialogues from a total of 44 Korean historical video works available on Netflix. The study pointed out that existing history textbooks for foreigners are not suitable for foreign learners of Korean and highlighted the issue that it increases the burden on instructors to thoroughly teach both Korean culture and history in actual Korean language learning settings. As an alternative, the study proposed the use of Korean historical video content and, based on previous research showing that watching videos with subtitles in the target language enhances learning effectiveness, organized frequently occurring grammar items in Korean historical video content by frequency, usage by social status, and usage by gender to assist learning.
Pengaruh Metode Struktural Analitik Sintetik (SAS) Berbantuan Media Kartu Kata Bergambar Terhadap Kemampuan Membaca Permulaan Pada Siswa Kelas 1 Sd Negeri 1 Suranenggala
Authors: Saadah Ida Inayatus , Wulan Neneng Sri , Sari Nadia Tiara Antik
Published: August 2024

Membaca permulaan sangat berperan bagi siswa supaya mereka bisa mempunyai pemahaman terhadap suatu bacaan maupun kalimat teks dalam lingkupan yang sederhana. Penelitian ini mempunyai tujuan untuk mengetahui adanya pengaruh penggunaan Metode Struktural Analitik Sintetik (SAS) Berbantuan Media Kartu Kata Bergambar terhadap kemampuan membaca permulaan siswa kelas 1 SD Negeri 1 Surananggala. Penelitian ini menggunakan jenis penelitian  Quasi Eksperimen dengan menggunakan desain non-equivalent control group design. Sampel yang digunakan pada penelitian ini yaitu siswa kelas 1A dan 1B SD Negeri 1 Suranenggala yang masing-masing kelas terdiri dari 30 siswa kelas eksperimen dan kontrol. Teknik pengumpulan data yang digunakan pada penelitian ini yaitu tes dan non tes menggunakan pretest, posttest serta lembar observaasi . Analisis deskriptif dilakukan untuk mengetahui nilai rata-rata pretest dan posttest kelas eksperimen maupun kontrol, sedangkan analisis inferensial dilakukan untuk mengetahui ada pengaruh atau tidak terdapatnya pengaruh metode Struktural Analitik Sintetik (SAS) berbantuan media kartu kata bergambar terhadap kemampuan membaca permulaan. Analisis deskriptif menyimpulkan bahwa kemampuan membaca permulaan siswa pada kelas eksperimen sebelum perlakuan mendapat rata-rata 65,80,  kelas kontrol 60,20. Setelah mendapatkan treatment rata-rata kelas eksperimen 76,20, kelas kontrol sebesar 66,33. Analisis inferensial menyimpulkan bahwa terdapat pengaruh penggunaan metode Struktural Analitik Sintetik (SAS) berbantuan media kartu kata bergambar terhadap kemampuan membaca permulaan siswa. Hal tersebut dapat dilihat dari uji wilcoxon.
Peran Supervisi Pendidikan dalam Meningkatkan Mutu Pendidikan
Authors: Cahayati Reni , Rizqa Miftahir
Published: August 2024

Mengetahui bagaimana supervisi pendidikan berperan  terhadap peningkatan mutu pendidikan adalah tujuan dari penelitian ini. Metode studi literatur digunakan dalam penelitian ini untuk mencapai tujuan tersebut. Penelitian ini menunjukkan bahwa kapasitas kepala sekolah dalam memberikan arahan, bimbingan, dan dukungan yang dibutuhkan guru agar berhasil pada tingkat yang diperlukan berhubungan dengan pengawasan. Pengawasan yang efektif haruslah bersifat kolaboratif dan suportif. Supervisor harus bekerja sama dengan guru untuk membantu mereka meningkatkan kualitas pembelajaran dan mengembangkan kompetensi profesionalnya.
Expérience et importance des soins de survie pour améliorer la qualité de vie des immigrantes atteintes d’un cancer du sein : revue systématique qualitative
Authors: D’Souza Melba , Apelegan Tolulope , Nairy Ashwin
Published: August 2024

Introduction : Les approches de soins holistiques adaptées aux besoins des patients améliorent la qualité de vie. Toutefois, les besoins des femmes immigrantes ayant survécu à un cancer du sein n’ont reçu que peu d’attention. Les barrières linguistiques compliquent considérablement l’accès aux soins de santé, de même que la capacité des femmes à comprendre l’information fournie par les professionnels afin de prendre leur propre santé en charge. L’objectif de la présente revue est d’examiner l’expérience des soins de survie et leur importance pour améliorer la qualité de vie des immigrantes ayant survécu à un cancer du sein. Méthodologie : La présente revue qualitative systématique regroupe des articles de recherche empirique évalués ou non par comité de lecture. Les études retenues portent sur les femmes immigrantes ayant reçu un diagnostic de cancer du sein et une première série de traitements. Étaient exclus les travaux portant sur les femmes non immigrantes, les hommes, les jeunes de moins de 18 ans, les personnes n’ayant pas eu de diagnostic de cancer du sein, celles qui n’étaient pas en traitement actif ou avancé, et celles qui recevaient des soins palliatifs ou de fin de vie. La synthèse thématique et la revue systématique qualitative ciblaient les études sur les soins de survie axées sur les traitements contre le cancer du sein et la période post-traitement. Les articles ont été repérés à l’aide de recherches dans PubMed/MEDLINE, CINAHL, Embase, PsycINFO, Web of Science et Google Scholar, et les résultats organisés selon la méthodologie du Joanna Briggs Institute (JBI). Résultats : Vingt études ont été retenues, de qualité moyenne à élevée. La synthèse thématique a fait ressortir deux thèmes généraux, subdivisés en sous-thèmes. Pour le premier thème (difficultés et expériences entourant l’accès aux soins de santé et l’utilisation des services), les sous-thèmes étaient : couverture d’assurance et d’avantages sociaux insuffisante, acculturation moindre et influence sur la prise de décisions, discrimination et traitement différentiel, influence des facteurs socioculturels. Pour le second thème (facteurs qui facilitent ou entravent l’accès aux services de santé et leur utilisation), les sous-thèmes étaient : connaissances insuffisantes et communication inefficace, manque de continuité et d’information, barrières culturelles et linguistiques, accès limité aux services et qualité des soins. Conclusion : Il est essentiel de soutenir les femmes immigrantes tout au long de l’expérience du cancer du sein et de les faire participer au processus. Pour ce faire, il faudra intégrer à la pratique les progrès réalisés dans le domaine des soins de survie en adoptant une approche méthodique afin d’améliorer la qualité de vie et l’état de santé rapporté par les patientes.
Describing the practice of breast self-examination and associated factors among female healthcare workers in Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
Authors: Desalegn Meskerem , Tufa Muluneh
Published: August 2024

Background: Breast cancer is the most frequently occurring cancer in women and is a global health problem. Yet, it can be a manageable disease with early diagnosis and sufficient treatment protocols, such as advanced surgical intervention, chemotherapy, and radiation therapies. Breast self-examination (BSE) is a screening technique that involves examining one’s breasts for lumps, distortions, or swelling, and contributes to early diagnosis of the disease. Objectives: The aim of this study was to assess the practice of BSE and associated factors among female healthcare workers in Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia, 2022 Methods: An institution-based cross-sectional study was carried out at St. Paul’s Hospital Millennium Medical College. A stratified and systematic random sampling technique was utilized to obtain respondents for the study. The data for this study were collected by professional nurses using a structured questionnaire. Data were analyzed using SPSS (version 20) software. Logistic regression analysis was utilized to assess relevant factors. Predictors with a p-value of < 0.05 were considered as statistically significant. Results: Four hundred respondents participated giving a 100% response rate. The median age of study participants was 28 years, with an inter-quartile range of six years. About two-thirds (63.8%) of the study participants had good knowledge about BSE, 46.3% had a positive attitude toward BSE, and 76.25% reported they practised BSE. Significant associations were observed with the practice of BSE and the factors of age, monthly income, and knowledge about BSE. Compared to participants 40 years and above, participants between 25–29 years [AOR=0.10; 95%CI: 0.01, 0.88] and 35–39 years [AOR=0.09; 95%CI: 0.01, 0.92] were less likely to practise BSE; those with monthly income less than 5250 ETB [AOR=0.19; 95%CI: 0.035, 0.996], and between 5251–7800 [AOR=0.16; 95%CI: 0.032, 0.78], and 7801-10900ETB [AOR=0.18; 95%CI: 0.04, 0.83] were less likely to practise BSE; and those with good knowledge about BSE [AOR=2.08; 95%CI: 1.23, 3.53] were more apt to practise BSE. Conclusion: The study showed that about three-quarters of the health workers practised BSE. Statistically significant associations were observed between BSE and the factors of age in years, monthly income, and knowledge about BSE. Keywords: breast, breast self-examination, Ethiopia, health care
Use and impact of virtual resources for peer support by young adults living with cancer: A systematic review
Authors: Martens Riley , Hou Mary , Isherwood Susan , Hunter-Smith Alison , Quan May-Lynn , Cuthbert Colleen
Published: August 2024

Background: Young adults (YA) with cancer often have unmet psychosocial needs. The impact of peer support delivered in an online format to fulfil these needs in the populations of YA with cancer has not been thoroughly examined. Methods: We searched Cochrane Central Register of Controlled Trials, CINAHL, Embase, and Medline databases. We included articles about online peer support interventions for YA cancer survivors between the ages of 18 to 40 years old. Results: Our literature search yielded n = 2,773 articles and we obtained consensus on 12 articles for inclusion. We qualitatively synthesized these articles using data abstraction based on the Template for Intervention and Replication (TIDierR) checklist. Overall, six studies demonstrated correlation between online peer support and improved wellbeing of participants. Thus, online peer support may be useful for young cancer patients. Conclusion: This systematic review summarizes the current state of knowledge regarding the availability and evaluation of online YA peer support programs and reveals the need for further research in this field. Keywords: young adult, social support, cancer survivor, social survivorship, social media, internet-based intervention
Recovery of the copper layer from waste mobile phone printed circuit board without crushing - Figures 4-6
Authors: Rahman Moshrefur , Rahman Abdur
Published: August 2024

Resource recovery and material reuse from waste is an art of circular economy. Waste mobile phone printed circuit boards contain a significant quantity of nonferrous and precious metals, where copper is one of the most abundant nonferrous elements. This paper presents the recovery of copper material using an electrochemical process from three samples of waste mobile phone printed circuit boards, two of them double-sided, where for sample preparation, crushing and dismantling are not applied except that the painting mask is chemically removed. From mass analysis, the gross amount of the recovered copper from the sample materials was 5.94 g and the calculated average mass was 1.98 g per sample material. In this way, the copper layer from waste mobile phone printed circuit boards could be recovered early and economically, which could reduce complexity and improve further material recovery compared to the traditional crushing practice.
Regulating Clinical Trials
Authors:   Parliamentary Office of Science and Technology, Bunce Samuel , Border Peter
Published: August 2024

This POSTnote describes the new EU Clinical Trial Regulation and the timetable for its implementation and examines its likely impact on the regulation of clinical trials in the UK post-Brexit.
Studi Penafsiran Mitsaqan Ghalizha dalam Tafsir Fii Zhilalil Qur’an
Authors: Dinnillah Fitria Izzah
Published: August 2024

Tujuan Al-Qur’an diturunkan adalah untuk memberi petunjuk bagi manusia, yang menuntun kepada jalan yang lurus. Petunjuk-petunjuk yang mengandung pesan moral tersebut, harus dipahami dan diinterpretasikan dari setiap kata tanpa ada kepentingan dan tendensi yang menguntungkan diri sendiri. Berbagai pesan moral dalam Al-Qur’an harus dipelajari dan dipahami secara utuh dan komprehensif. Termasuk diantaranya adalah masalah janji. Terdapat banyak terminologi janji dalam al-Qur’an, salah satunya adalah mîtsâqan ghalîzha. Penelitian ini bertujuan untuk mengetahui penafsiran Sayyid Quthb terhadap ayat-ayat mîtsâqan ghalîzha dalam perspektif Tafsir Fî Zhilâlil Qur’an dan pendekatan yang beliau gunakan dalam menafsirkan ayat-ayat tersebut. Penelitian ini adalah penelitian pustaka (library research) melalui pendekatan tafsir maudhu’i (tematik) dengan kombinasi komparatif (perbandingan). Hasil penelitian menunjukkan bahwa mîtsâqan ghalîzha menurut Sayyid Quthb adalah tali yang terpintal kemudian dipakai untuk menggambarkan tentang sumpah dan perjanjian yang bersifat kuat, kokoh dan mantap. Dan pendekatan yang beliau gunakan untuk menafsirkan ayat-ayat mîtsâqan ghalîzha dalam tafsir Fî Zhilâlil Qur’an adalah tahlili.
Knee rotation in patients with and without patellofemoral instability and its correlation with patellar tendon trochlear groove distance
Authors: Gupta Himanshu , Jain Vineet , Kataria Nilansh , Upadhyay Ashish Dutt , Mishra Pallav , Kataria Himanshu
Published: August 2024

Background and study aims: There are limited studies assessing the role of “knee rotation” in patellofemoral instability (PFI). Knee rotation is the external rotation of the proximal tibia with respect to distal femur. The study was performed to compare knee rotation, patellar tendon lateralisation and patellar tendon trochlear groove (PTTG) distance measured on MRI between patients with and without PFI and to assess the relative association of these factors with PFI.
Materials and methods: It was a retrospective cross-sectional study done on archival MRI films. A sample size of 20 for PFI group and 60 for control group was taken. PTTG distance, knee rotation and lateralisation of patellar tendon insertion were measured as described in literature. The knee rotation and patellar tendon lateralisation between PFI and non-PFI group were compared using t-test and their Pearson’s correlation (r) with PTTG distance was calculated. Relative associations of these factors with PFI were assessed using multivariate regression.
Results: Lateralisation of patellar tendon insertion and external knee rotation were both found to be higher in PFI patients as compared to non-PFI patients. However,on taking PTTG distance into consideration, the associations of knee rotation as well as of patellar tendon lateralisation with PFI did not remain significant in generalised linear modeling. Overall, the PTTG distance showed moderate to strong correlation with the external knee rotation as well as with lateralisation of patellar tendon insertion.
Conclusions: Knee rotation was found to be significantly higher in PFI patients as compared to controls. However, PTTG distance appears to be a composite measure that takes into account the influence of both the patellar tendon lateralisation as well as knee rotation on patellofemoral biomechanics.