bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Analysis of the Cecal Microbiome and Plasma Metabolomics to Explore NaoMaiTong and Its Potential Role in Changing the Intestinal Flora and Their Metabolites in Ischemic Stroke
Authors: Lin Huiting , Chen Shaoru , Shen Lin , Hu Tao , Cai Jiale , Zhan Sikai , Liang Jiayin , Huang Mingmin , Xian Minghua , Wang Shumei
Published: January 2022

Ischemic stroke (IS), as a leading cause of disability worldwide, affects intestinal bacterial communities and their metabolites, while recent discoveries have highlighted the importance of the intestinal microflora in the development of IS. Systematic investigations of complex intestinal bacterial communities and their metabolites during ischemic brain injury contribute to elucidate the promising therapeutic targets for IS. However, the associations between intestinal microbiota and related circulating metabolic processes in IS remained unclear. Hence, to identify the changed microflora and their metabolites in IS of NaoMaiTong (NMT), an effective clinical medication, we established the middle cerebral artery occlusion/reperfusion (MCAO/R) model using conventionalized and pseudo-germ-free (PGF) rats. Subsequently, we systematically screen the microflora and related metabolites changing in IS via an integrated approach of cecal 16S rRNA sequencing combined with plasma metabolomics. We found that NMT relied on intestinal flora to improve stroke outcome in conventionalized rats while the protection of NMT was reduced in PGF rats. Total 35 differential bacterial genera and 26 differential microbial metabolites were regulated by NMT. Furthermore, L-asparagine and indoleacetaldehyde were significantly negatively correlated with Lachnospiraceae_UCG.001 and significantly positively correlated with Lachnoclostridium. Indoleacetaldehyde also presented a negative correlation with Lactobacillus and Bifidobacterium. 2-Hydroxybutyric acid was strongly negatively correlated with Ruminococcus, Lachnospiraceae_UCG.001 and Lachnospiraceae_UCG.006. Creatinine was strongly negatively correlated with Akkermansia. In summary, the research provided insights into the intricate interaction between intestinal microbiota and metabolism of NMT in IS. We identified above differential bacteria and differential endogenous metabolites which could be as prebiotic and probiotic substances that can influence prognosis in stroke and have potential to be used as novel therapeutic targets or exogenous drug supplements.
Platelet Mechanobiology Inspired Microdevices: From Hematological Function Tests to Disease and Drug Screening
Authors: Zhang Yingqi , Jiang Fengtao , Chen Yunfeng , Ju Lining Arnold
Published: January 2022

Platelet function tests are essential to profile platelet dysfunction and dysregulation in hemostasis and thrombosis. Clinically they provide critical guidance to the patient management and therapeutic evaluation. Recently, the biomechanical effects induced by hemodynamic and contractile forces on platelet functions attracted increasing attention. Unfortunately, the existing platelet function tests on the market do not sufficiently incorporate the topical platelet mechanobiology at play. Besides, they are often expensive and bulky systems that require large sample volumes and long processing time. To this end, numerous novel microfluidic technologies emerge to mimic vascular anatomies, incorporate hemodynamic parameters and recapitulate platelet mechanobiology. These miniaturized and cost-efficient microfluidic devices shed light on high-throughput, rapid and scalable platelet function testing, hematological disorder profiling and antiplatelet drug screening. Moreover, the existing antiplatelet drugs often have suboptimal efficacy while incurring several adverse bleeding side effects on certain individuals. Encouraged by a few microfluidic systems that are successfully commercialized and applied to clinical practices, the microfluidics that incorporate platelet mechanobiology hold great potential as handy, efficient, and inexpensive point-of-care tools for patient monitoring and therapeutic evaluation. Hereby, we first summarize the conventional and commercially available platelet function tests. Then we highlight the recent advances of platelet mechanobiology inspired microfluidic technologies. Last but not least, we discuss their future potential of microfluidics as point-of-care tools for platelet function test and antiplatelet drug screening.
Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?
Authors: Quan Yunyun , Li Li , Yin Zhujun , Chen Shilong , Yi Jing , Lang Jirui , Zhang Lu , Yue Qianhua , Zhao Junning
Published: January 2022

Bulbus fritillariae cirrhosae (BFC) is one of the most used Chinese medicines for lung disease, and exerts antitussive, expectorant, anti-inflammatory, anti-asthmatic, and antioxidant effects, which is an ideal therapeutic drug for respiratory diseases such as ARDS, COPD, asthma, lung cancer, and pulmonary tuberculosis. Through this review, it is found that the therapeutic mechanism of BFC on respiratory diseases exhibits the characteristics of multi-components, multi-targets, and multi-signaling pathways. In particular, the therapeutic potential of BFC in terms of intervention of “cytokine storm”, STAT, NF-κB, and MAPK signaling pathways, as well as the renin-angiotensin system (RAS) that ACE is involved in. In the “cytokine storm” of SARS-CoV-2 infection there is an intense inflammatory response. ACE2 regulates the RAS by degradation of Ang II produced by ACE, which is associated with SARS-CoV-2. For COVID-19, may it be a potential drug? This review summarized the research progress of BFC in the respiratory diseases, discussed the development potentiality of BFC for the treatment of COVID-19, explained the chemical diversity and biological significance of the alkaloids in BFC, and clarified the material basis, molecular targets, and signaling pathways of BFC for the respiratory diseases. We hope this review can provide insights on the drug discovery of anti-COVID-19.
The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation
Authors: Deuis Jennifer R. , Ragnarsson Lotten , Robinson Samuel D. , Dekan Zoltan , Chan Lerena , Jin Ai-Hua , Tran Poanna , McMahon Kirsten L. , Li Shengnan , Wood John N. , Cox James J. , King Glenn F. , Herzig Volker , Vetter Irina
Published: January 2022

Venoms from cone snails and arachnids are a rich source of peptide modulators of voltage-gated sodium (NaV) channels, however relatively few venom-derived peptides with activity at the mammalian NaV1.8 subtype have been isolated. Here, we describe the discovery and functional characterisation of β-theraphotoxin-Eo1a, a peptide from the venom of the Tanzanian black and olive baboon tarantula Encyocratella olivacea that modulates NaV1.8. Eo1a is a 37-residue peptide that increases NaV1.8 peak current (EC50 894 ± 146 nM) and causes a large hyperpolarising shift in both the voltage-dependence of activation (ΔV50–20.5 ± 1.2 mV) and steady-state fast inactivation (ΔV50–15.5 ± 1.8 mV). At a concentration of 10 μM, Eo1a has varying effects on the peak current and channel gating of NaV1.1–NaV1.7, although its activity is most pronounced at NaV1.8. Investigations into the binding site of Eo1a using NaV1.7/NaV1.8 chimeras revealed a critical contribution of the DII S3-S4 extracellular loop of NaV1.8 to toxin activity. Results from this work may form the basis for future studies that lead to the rational design of spider venom-derived peptides with improved potency and selectivity at NaV1.8.
Platelet-Derived Growth Factor-BB Inhibits Intervertebral Disc Degeneration via Suppressing Pyroptosis and Activating the MAPK Signaling Pathway
Authors: Zhang Weikang , Gong Yuhang , Zheng Xiaohang , Qiu Jianxin , Jiang Ting , Chen Lihua , Lu Fangying , Wu Xinhui , Cheng Fengmin , Hong Zhenghua
Published: January 2022

Platelet-derived growth factor-BB (PDGF-BB) is a cytokine involved in tissue repair and tumor progression. It has been found to have expression differences between normal and degenerative intervertebral discs. However, it is not clear whether PDGF-BB has a protective effect on intervertebral disc degeneration (IDD). In this experiment, we treated nucleus pulposus cells (NPCs) with IL-1β to simulate an inflammatory environment and found that the extracellular matrix (ECM) anabolic function of NPCs in an inflammatory state was inhibited. Moreover, the induction of IL-1β also enhanced the expression of NLRP3 and the cleavage of caspase-1 and IL-1β, which activated the pyroptosis of NPCs. In this study, we studied the effect of PDGF-BB on IL-1β-treated NPCs and found that PDGF-BB not only significantly promotes the ECM anabolism of NPCs, but also inhibits the occurrence of pyroptosis and the production of pyroptosis products of NPCs. Consistent with this, when we used imatinib to block the PDGF-BB receptor, the above-mentioned protective effect disappeared. In addition, we found that PDGF-BB can also promote the ECM anabolism of NPCs by regulating the ERK, JNK, PI3K/AKT signaling pathways, but not the P38 signaling pathway. In vivo studies, mice that blocked PDGF-BB receptors showed more severe histological manifestations of intervertebral disc degeneration. In summary, our results indicate that PDGF-BB participates in inhibiting the occurrence and development of IDD by inhibiting pyroptosis and regulating the MAPK signaling pathway.
Undifferentiated Connective Tissue Disease in Pregnancy: A Topic Yet to be Explored
Authors: Serena Caterina , Clemenza Sara , Simeone Serena , Zullino Sara , Ottanelli Serena , Rambaldi Marianna Pina , Vannuccini Silvia , Petraglia Felice , Mecacci Federico
Published: January 2022

Undifferentiated connective tissue disease (UCTD) is characterized by signs and symptoms suggestive of a connective tissue disease (CTD), but not fulfilling criteria for a specific CTD. Although UCTD is probably the most common rheumatic disease diagnosed in pregnant women, data about disease course during pregnancy and perinatal outcomes are very limited. Compared to other CTDs, UCTD seems to have milder clinical manifestations in pregnancy. Its natural history is related to disease activity at conception. In fact, if the disease is in a state of remission or minimal activity at conception, pregnancy outcomes are generally good. On the contrary, patients who become pregnant in a moment of high disease activity and/or who have multiple antibodies positivity show an increased risk of disease flares, evolution to a definite CTD and obstetric complications, such as fetal growth restriction, preeclampsia and preterm birth. Therefore, a preconception assessment is essential in women with UCTD to evaluate maternal and fetal risks, to initiate interventions to optimize disease activity, and to adjust medications to those that are least harmful to the fetus. The aim of the present study was to review the available literature about pregnancy course, maternal and fetal outcomes and therapeutic approaches of pregnant women with UCTD.
Sequelae and Comorbidities of COVID-19 Manifestations on the Cardiac and the Vascular Systems
Authors: Batta Yashvardhan , King Cody , Johnson John , Haddad Natasha , Boueri Myriam , Haddad Georges
Published: January 2022

COVID-19 patients with pre-existing cardiovascular conditions are at greater risk of severe illness due to the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus. This review evaluates the highest risk factors for these patients, not limited to pre-existing hypertension, cardiac arrhythmias, hypercoagulation, ischemic heart disease, and a history of underlying heart conditions. SARS-CoV-2 may also precipitate de novo cardiac complications. The interplay between existing cardiac conditions and de novo cardiac complications is the focus of this review. In particular, SARS-CoV-2 patients present with hypercoagulation conditions, cardiac arrhythmias, as significant complications. Also, cardiac arrhythmias are another well-known cardiovascular-related complication seen in COVID-19 infections and merit discussion in this review. Amid the pandemic, myocardial infarction (MI) has been reported to a high degree in SARS-CoV-2 patients. Currently, the specific causative mechanism of the increased incidence of MI is unclear. However, studies suggest several links to high angiotensin-converting enzyme 2 (ACE2) expression in myocardial and endothelial cells, systemic hyper-inflammation, an imbalance between myocardial oxygen supply and demand, and loss of ACE2-mediated cardio-protection. Furthermore, hypertension and SARS-CoV-2 infection patients’ prognosis has shown mixed results across current studies. For this reason, an in-depth analysis of the interactions between SARS-CoV2 and the ACE2 cardio-protective mechanism is warranted. Similarly, ACE2 receptors are also expressed in the cerebral cortex tissue, both in neurons and glia. Therefore, it seems very possible for both cardiovascular and cerebrovascular systems to be damaged leading to further dysregulation and increased risk of mortality risk. This review aims to discuss the current literature related to potential complications of COVID-19 infection with hypertension and the vasculature, including the cervical one. Finally, age is a significant prognostic indicator among COVID-19 patients. For a mean age group of 70 years, the main presenting symptoms include fever, shortness of breath, and a persistent cough. Elderly patients with cardiovascular comorbidities, particularly hypertension and diabetes, represent a significant group of critical cases with increased case fatality rates. With the current understanding of COVID-19, it is essential to explore the mechanisms by which SARS-CoV-2 operates to improve clinical outcomes for patients suffering from underlying cardiovascular diseases and reduce the risk of such conditions de novo.
Central Pressure Waveform-Derived Indexes Obtained From Carotid and Radial Tonometry and Brachial Oscillometry in Healthy Subjects (2–84 Y): Age-, Height-, and Sex-Related Profiles and Analysis of Indexes Agreement
Authors: Zócalo Yanina , Bia Daniel
Published: January 2022

Aortic blood pressure (aoBP) waveform-derived indexes could provide valuable (prognostic) information over and above cardiovascular risk factors (CRFs). To obtain aoBP waveform-characteristics, several (i) techniques, (ii) recording sites, (iii) pressure-only waveform analysis mathematical approaches [e.g., pulse wave analysis (PWA), wave separation analysis (WSA)], and (iv) indexes [augmentation pressure and index (AP and AIx), forward (Pf) and backward (Pb) components of aoBP, reflection magnitude (RM), and reflection index (Rix)], were proposed. An accurate clinical use of these indexes requires knowing their physiological age-related profiles and the expected values for a specific subject. There are no works that have characterized waveform-derived indexes profiles in large populations considering: (i) as a continuous, data from different age stages (childhood, adolescence, and adulthood), (ii) complementary indexes, (iii) data obtained from different techniques and approaches, and (iv) analyzing potential sex- and body height (BH)-related differences. In addition, (v) there is a lack of normative data (reference intervals, RIs) for waveform-derived indexes.

Aims

(1) to evaluate the association and agreement between PWA- and/or WSA-derived indexes obtained with different techniques and approaches; (2) to determine the need for sex-, BH-, and/or age-specific RIs; (3) to define RIs for PWA- and WSA-derived indexes in a large cohort of healthy children, adolescents, and adults.

Methods

3619 subjects (3–90 y) were included; 1688 healthy (2–84 y). AP, AIx, AIx@75, Pf, Pb, RM, and RIx were obtained (carotid and radial tonometry, brachial oscillometry/plethysmography). The association and agreement between indexes were analyzed (Concordance correlation coefficients, Bland–Altman analysis). Mean and SD equations and sex-specific BH- and age-related profiles were obtained (regression methods; fractional polynomials).

Results

Waveform-derived indexes were not equivalent; for a specific index, there were systematic and proportional differences associated with the recording site (e.g., carotid vs. radial) and technique (e.g., tonometry vs. oscillometry). The need for sex-, BH-, or age-specific RIs was dependent on the index and/or age considered. RIs were defined for each index considering differences between recording sites and techniques. Equations for waveform-derived indexes age-related profiles were included, enabling to determine for a specific subject, the expected values and potential data deviations.
Maternal Fatty Acid Metabolism in Pregnancy and Its Consequences in the Feto-Placental Development
Authors: Duttaroy Asim K. , Basak Sanjay
Published: January 2022

During pregnancy, maternal plasma fatty acids are critically required for cell growth and development, cell signaling, and the development of critical structural and functional aspects of the feto-placental unit. In addition, the fatty acids modulate the early stages of placental development by regulating angiogenesis in the first-trimester human placenta. Preferential transport of maternal plasma long-chain polyunsaturated fatty acids during the third trimester is critical for optimal fetal brain development. Maternal status such as obesity, diabetes, and dietary intakes may affect the functional changes in lipid metabolic processes in maternal-fetal lipid transport and metabolism. Fatty acids traverse the placental membranes via several plasma membrane fatty acid transport/binding proteins (FAT, FATP, p-FABPpm, and FFARs) and cytoplasmic fatty acid-binding proteins (FABPs). This review discusses the maternal metabolism of fatty acids and their effects on early placentation, placental fatty acid transport and metabolism, and their roles in feto-placental growth and development. The review also highlights how maternal fat metabolism modulates lipid processing, including transportation, esterification, and oxidation of fatty acids.
Repeated Interval Loughborough Soccer Passing Tests: An Ecologically Valid Motor Task to Induce Mental Fatigue in Soccer
Authors: Bian Chao , Ali Ajmol , Nassis George P. , Li Yongming
Published: January 2022

Most studies investigating mental fatigue (MF) in soccer utilized a computerized Stroop task to induce MF. However, the traditional key-pressing task has been challenged for its lack of ecological validity. The limited relevance to real-life soccer made it difficult to bridge the gap between the research and the applied setting. Therefore, a novel soccer-specific inducing task is in urgent need. This study compared a novel MF-inducing task in soccer with the Stroop task and investigated the impact of induced MF on cognitive and soccer-specific skill performance. A randomized, counterbalanced crossover design was employed. Fifteen well-trained male soccer players randomly participated in three MF-inducing tasks. Two of them were motor tasks consisting of 10 repeated interval Loughborough Soccer Passing Test (10xLSPT or LSPT) in clockwise passing order (10xC-LSPT) with each block starting every 2 min. The two tasks share the same movement pattern, but C-LSPT is considered to have lower cognitive demands. The third was the 20-min Stroop task (Stroop-20). MF was assessed immediately before and after each task by visual analog scale (VAS), the cognitive performance in a 3-min Stroop task, and the skill performance in one LSPT. Subjective MF increased similarly after 10xLSPT and Stroop-20 (+ 25.4 ± 10.3 vs. + 23.4 ± 10.8 AU, p = 0.607). The induced MF by 10xLSPT and Stroop-20 had no impact on cognitive performance and movement time but similarly affected in a significantly negative manner on penalty time (+ 5.9 ± 4.9 vs. + 5.4 ± 4.2 s, p = 0.748) and passing accuracy (–1.4 ± 1.5 vs. –1.0 ± 1.3, p = 0.465). Two motor tasks shared similar intensity, but 10xC-LSPT was inefficient to induce MF. The results showed that the 20-min repeated interval LSPT could induce a similar MF as the Stroop task. The induced MF had detrimental effects on soccer skill performance. The novel motor task is recommended for MF studies in soccer as an inducement task. Practitioners should be cautious about the prolonged cognitive-demanding skill section of the pre-match warm-up to avoid the negative effect of MF on the upcoming match. This motor task pattern could be followed as a supplementary training protocol.
Strong Environmental Filtering Based on Hydraulic Traits Occurring in the Lower Water Availability of Temperate Forest Communities
Authors: Zhao Jiale , Zhang Yuhan , Xu Jinshi , Chai Yongfu , Liu Peiliang , Cao Ying , Li Cunxia , Yin Qiulong , Zhu Jiangang , Yue Ming
Published: January 2022

The trait-based approaches have made progress in understanding the community assembly process. Here, we explore the key traits that may shape community assembly patterns of the same community type but within different water availabilities. Natural Quercus wutaishanica forests were chosen as a suitable study system to test the difference between economic and hydraulic traits across water availability on the Loess Plateau (LP, drought region) and Qinling Mountains (QL, humid region) of China. A total of 75 plots were established separately in two sites, and 12 functional traits (seven hydraulic traits and five economic traits) of 167 species were studied. Community-weighted mean trait values and functional diversity indices were compared between the two sites. Canonical component analysis was performed to infer whether the changes of community traits and their relationships are driven by intraspecific variation or species turnover. Evidence for likely community assembly processes was tested using the null model to determine whether functional structure among seven hydraulic traits and five economic traits was dominated by different ecological processes between two sites. We found that forests in the Loess Plateau and Qinling Mountains showed different hydraulic and economic traits. Hydraulic and economic traits coupled at the community level were driven by species turnover. Hydraulic traits showed more significant convergent patterns on LP than that in QL. Our results suggest a strong environmental filtering process occurred in hydraulic-based community assembly in the temperate forest with low water availability. Reveal the relationship of hydraulic and economic traits at the community level. Emphasize the critical role of multi-dimensional traits selecting like hydraulic traits in community ecology.
A Plant Disease Recognition Method Based on Fusion of Images and Graph Structure Text
Authors: Wang Chunshan , Zhou Ji , Zhang Yan , Wu Huarui , Zhao Chunjiang , Teng Guifa , Li Jiuxi
Published: January 2022

The disease image recognition models based on deep learning have achieved relative success under limited and restricted conditions, but such models are generally subjected to the shortcoming of weak robustness. The model accuracy would decrease obviously when recognizing disease images with complex backgrounds under field conditions. Moreover, most of the models based on deep learning only involve characterization learning on visual information in the image form, while the expression of other modal information rather than the image form is often ignored. The present study targeted the main invasive diseases in tomato and cucumber as the research object. Firstly, in response to the problem of weak robustness, a feature decomposition and recombination method was proposed to allow the model to learn image features at different granularities so as to accurately recognize different test images. Secondly, by extracting the disease feature words from the disease text description information composed of continuous vectors and recombining them into the disease graph structure text, the graph convolutional neural network (GCN) was then applied for feature learning. Finally, a vegetable disease recognition model based on the fusion of images and graph structure text was constructed. The results show that the recognition accuracy, precision, sensitivity, and specificity of the proposed model were 97.62, 92.81, 98.54, and 93.57%, respectively. This study improved the model robustness to a certain extent, and provides ideas and references for the research on the fusion method of image information and graph structure information in disease recognition.
Gender Differences Influence Gender Equality Awareness, Self-Esteem, and Subjective Well-Being Among School-Age Children in China
Authors: Li Yifei , Zuo Man , Peng Yirong , Zhang Jie , Chen Yiping , Tao Yingxiang , Ye Biyun , Zhang Jingping
Published: January 2022

The objective of this study was to investigate and analyze the status and influential factors of gender equality awareness, self-esteem, and subjective well-being in school-age boys and girls. The results can help schools and teachers provide more effective gender equality and mental health education. In the study, 284 valid questionnaires were collected from a total of 323 school-age boys and girls in the Hunan Province, China (effective response rate of 87.93%). The questionnaire covered gender equality awareness, self-esteem, and subjective well-being, with the influencing factors analyzed through multiple linear regression. There was a significant correlation among children’s gender equality awareness in all areas examined (family, occupation, and school), with both boys and girls having the lowest awareness of gender equality in occupational fields. The children’s self-esteem and subjective well-being were significantly correlated as well. Gender equality awareness, self-esteem, and subjective well-being among boys and girls reflected different influential factors. Androgynous traits (neither feminine nor masculine) were conducive to the development of gender equality awareness and self-esteem among the children. Therefore, schools and teachers need to provide gender equality and mental health education according to the specific psychological characteristics of each boy and girl.
Playing-Related Musculoskeletal Disorders, Risk Factors, and Treatment Efficacy in a Large Sample of Oboists
Authors: Macdonald Heather M. , Lavigne Stéphanie K. , Reineberg Andrew E. , Thaut Michael H.
Published: January 2022

Objectives

During their lifetimes, a majority of musicians experience playing-related musculoskeletal disorders (PRMD). PRMD prevalence is tied to instrument choice, yet most studies examine heterogeneous groups of musicians, leaving some high-risk groups such as oboists understudied. This paper aims to (1) ascertain the prevalence and nature of PRMDs in oboists, (2) determine relevant risk factors, and (3) evaluate the efficacy of treatment methods in preventing and remedying injuries in oboe players.

Methods

A 10-question online questionnaire on PRMDs and their treatments was completed by 223 oboists. PRMDs were compared across gender, weekly playing hours, career level, age, and years of playing experience.

Results

Of all respondents, 74.9% (167/223) reported having had at least one PRMD in their lifetime. A majority of these injuries (61.9% of all respondents) were of moderate to extreme severity (5 or higher on a scale of 1 to 10). Females (mean = 5.88) reported significantly more severe injuries than males. No significant effects of career level (i.e., professional vs. student vs. amateur), age, or years of playing experience were observed. We found significant non-linear relationships between weekly playing hours and PRMD prevalence and severity. Injuries were most commonly on the right side of the body, with the right thumb, wrist, hand, and forearm being most affected in frequency and severity. Of those injuries for which recovery information was provided, only 26.1% of injuries were “completely recovered.” The perceived effectiveness of a few treatments (physical therapy, rest, stretching, occupational therapy, massage) tended to be ranked more highly than others.

Conclusion

The oboists in this study experienced high rates of PRMD, particularly in the right upper extremities. Females and those playing 7-9 and 16-18 h per week reported a significantly higher severity of injuries than other groups.
Beyond the “Third Wave of Positive Psychology”: Challenges and Opportunities for Future Research
Authors: Wissing Marié P.
Published: January 2022

The positive psychology (PP) landscape is changing, and its initial identity is being challenged. Moving beyond the “third wave of PP,” two roads for future research and practice in well-being studies are discerned: The first is the state of the art PP trajectory that will (for the near future) continue as a scientific (sub)discipline in/next to psychology (because of its popular brand name). The second trajectory (main focus of this manuscript) links to pointers described as part of the so-called third wave of PP, which will be argued as actually being the beginning of a new domain of inter- or transdisciplinary well-being studies in its own right. It has a broader scope than the state of the art in PP, but is more delineated than in planetary well-being studies. It is in particular suitable to understand the complex nature of bio-psycho-social-ecological well-being, and to promote health and wellness in times of enormous challenges and changes. A unique cohering focus for this post-disciplinary well-being research domain is proposed. In both trajectories, future research will have to increase cognizance of metatheoretical assumptions, develop more encompassing theories to bridge the conceptual fragmentation in the field, and implement methodological reforms, while keeping context and the interwovenness of the various levels of the scientific text in mind. Opportunities are indicated to contribute to the discourse on the identity and development of scientific knowledge in mainstream positive psychology and the evolving post-disciplinary domain of well-being studies.
Embarrassing Product, Image Type, and Personal Pronoun: The Mediating Effect of Body Imagery
Authors: Ye Shenghong , Yan Haoyun , Lin Zhengyu , Huang Zan
Published: January 2022

Consumers often feel embarrassed when buying products like condoms, hemorrhoid cream, and beriberi cream in crowded pharmacies. There is an interesting phenomenon in life: Some beriberi creams use the images of a “real foot”, while others use the images of a “cartoon foot.” Imagine if a young woman needed to go to a retail store for beriberi cream that would embarrass her, she would choose a “real foot image” or a “cartoon foot image” beriberi cream? It has been shown that the embarrassment of these products has a strong negative impact on consumer buying behavior. Previous researches have explored how changing packaging elements of embarrassing products (e.g., color/design/image placement) can effectively reduce consumer embarrassment. However, few have examined the impact of different image types of embarrassing product packaging (artificial vs. natural) with embarrassment. Therefore, this research explores the effect of image types (artificial vs. natural) on consumers’ willingness to purchase embarrassing products and reveals the mechanisms of the underlying effects. The results show that natural images can lead to lower purchase intention of embarrassing products when the advertisement uses first-person pronouns due to the mediating role played by negative body imagery. However, there is no significant difference in purchase intention between different image types in the third-person pronouns. Finally, this paper discusses its contributions and limitations.
The VIDAS Data Set: A Spoken Corpus of Migrant and Refugee Spanish Learners
Authors: Planelles Almeida Margarita , Duñabeitia Jon Andoni , Doquin de Saint Preux Anna
Published: January 2022

The VIDAS data set (Verbal Interaction Dataset of Acquired Spanish) presents data from 200 participants from different countries and language backgrounds (50 Philippines with L1 Tagalog; 50 Ukrainians with L1 Ukrainian; 50 Moroccans with L1Arabic; 50 Romanians with L1 Romanian). They completed an oral expression and interaction test in the context of a Spanish certification exam for adult migrants. The aim of the VIDAS data set is to provide researchers in psycholinguistics and second language acquisition with a Spanish spoken corpus of traditionally marginalized and underrepresented learners, providing a compelling data set of oral interactions by migrants and refugees. The corpus contains more than 29 h of recordings of the oral interactions of the participants with trained interviewers, as well as background information about the participants (age, gender, maximum education level, years of residence, and language background). It furthermore contains the scores obtained by the participants in the oral expression and interaction exam. The VIDAS corpus allows for the development of studies on L2 spoken language comprehension and processing, as well as for comparative analyses of language acquisition between different L1 groups at different linguistic levels.
Viewing Cute Images Does Not Affect Performance of Computerized Reaction Time Tasks
Authors: Ziv Gal , Fox Orly
Published: January 2022

Humans are emotionally affected by cute or infantile appearances, typical of baby animals and humans, which in turn often leads to careful and cautious behavior. The purpose of this pre-registered study was to examine whether looking at cute images of baby pets improves performance of computerized cognitive-motor tasks. Ninety-eight participants were recruited for this online study and were randomly assigned to two experimental groups. The participants in one group performed two cognitive-motor tasks (Simon task and alternate task-switching task) before and after viewing images of adult pets and the participants in the other group performed the tasks before and after viewing images of baby pets. The participants who viewed images of baby pets rated them as significantly cuter (Cohen’sd= 0.50) and more infantile (Cohen’sd= 1.56) compared with those who viewed images of adult pets. All participants improved their performance from the pre-test to the post-test, but no differences in correct responses and reaction times were seen between the groups. However, pet ownership appeared to serve as a moderating variable with pet owners performing the Simon task faster than non-pet owners. In addition, pet owners reacted faster in the alternate task-switching task after viewing cute and infantile images but not after viewing images of adult pets. This effect was not found among non-pet owners. In conclusion, this study did not find that viewing cute images improves cognitive-motor performance, yet this may be dependent on moderators like pet ownership.
The Influence of COVID-19 on Entrepreneur's Psychological Well-Being
Authors: Xu Zhengda , Jia Heqi
Published: January 2022

This research focuses on the influence of COVID-19 on entrepreneurs' psychological well-being (PWB) in China. A start-up's performance is believed to play an important moderating role. This study uses 2 years of tracking data of 303 entrepreneurs from Shandong Providence, China. Based on conservation of resources (COR) theory, this study found that COVID-19 will significantly decrease entrepreneurs' PWB. A start-up's past performance will enhance the negative influence of COVID-19 on entrepreneurs' PWB. This study contributes to the literature on entrepreneurship, COR, and PWB. The findings can also guide entrepreneurs to maintain well-being during the pandemic and post-pandemic era.
Bulimia Symptoms in Russian Youth: Prevalence and Association With Internalizing Problems
Authors: Koposov Roman A. , Stickley Andrew , Ruchkin Vladislav
Published: January 2022

Background

There has been limited research on bulimia symptoms in adolescents from the general population outside the United States. This study aimed to evaluate the prevalence of bulimia symptoms in Russian youth and explore the associations between a clinical level of self-reported probable bulimia nervosa (BN) and internalizing problems, binge drinking and functional impairment by gender.

Methods

Data were collected from a representative sample of school students (N = 2,515, 59.5% female) from Northern Russia [age M (SD) = 14.89 ± 1.13 years]. Probable BN and internalizing psychopathology were assessed using self-report scales. Chi-square and independent sample t-tests were used to compare respondents' demographic characteristics and disordered eating behaviors. GLM multivariate analysis of covariance was used to assess the associations between probable BN, functional impairment and mental health problems (MHP) by gender.

Results

Analyses showed that the 3-month prevalence of probable BN was higher in girls (3.9%) than in boys (1.2%). Probable BN was associated with depressive and anxiety symptoms, somatic anxiety, somatic complaints, binge drinking and functional impairment. Boys reported a higher level of problem scores in relation to probable BN.

Conclusions

Our findings suggest that bulimia symptoms are prevalent in Russian adolescents and are associated with MHP and functional impairment. Timely recognition of bulimia symptoms and associated MHP is important for early prevention and intervention strategies.
Nurses Burnout, Resilience, and Its Association With Socio-Demographic Factors During COVID-19 Pandemic
Authors: Jamebozorgi Majid Heidari , Karamoozian Ali , Bardsiri Tayebe Ilaghinezhad , Sheikhbardsiri Hojjat
Published: January 2022

Background

In the recent pandemic, nurses have faced workload and being exposed to burnout. Resilience helps address work-related psychological problems such as stressful events and burnout. According to the roles of nurses in the healthcare system, we investigated the relationship between resiliency and burnout in nurses.

Material and Methods

In this descriptive analytical cross-sectional study, 364 nurses participated from April to June 2021. Census sampling was used to recruit participants. Maslach burnout inventory (MBI), Connor-Davidson Resiliency Scale (CDRISC), and a demographic check-list were utilized to collect data. Data analysis was done using SPSS version 22. Shapiro-Wilk, Kruskal–Wallis test, Mann–Whitney U-test, correlation analysis, and generalized linear model were applied accordingly.

Results

Overall, the findings showed that nurses had severe symptoms of burnout and a moderate level of resilience. The two domains of burnout, emotional exhaustion and personal accomplishment had a significantly negative correlation with resilience (r = −0.442, p < 0.001 and r = −0.351, p = 0.03, respectively). Linear regression showed that demographic characteristics (Hospital type, ward type, gender, and overtime) were the major predictors of the 3 sub-categories of burnout. A significant negative correlation was observed between burnout and resilience highlighting the role of resilience in reducing burnout (P < 0.05).

Conclusion

In order to help nurses to tackle and endure burnout in pandemic times, there is a need to implement national and local policies to help them accordingly.
Modeling the Global Dynamic Contagion of COVID-19
Authors: Xiang Lijin , Ma Shiqun , Yu Lu , Wang Wenhao , Yin Zhichao
Published: January 2022

The COVID-19 infections have profoundly and negatively impacted the whole world. Hence, we have modeled the dynamic spread of global COVID-19 infections with the connectedness approach based on the TVP-VAR model, using the data of confirmed COVID-19 cases during the period of March 23rd, 2020 to September 10th, 2021 in 18 countries. The results imply that, (i) the United States, the United Kingdom and Indonesia are global epidemic centers, among which the United States has the highest degree of the contagion of the COVID-19 infections, which is stable. South Korea, France and Italy are the main receiver of the contagion of the COVID-19 infections, and South Korea has been the most severely affected by the overseas epidemic; (ii) there is a negative correlation between the timeliness, effectiveness and mandatory nature of government policies and the risk of the associated countries COVID-19 epidemic affecting, as well as the magnitude of the net contagion of domestic COVID-19; (iii) the severity of domestic COVID-19 epidemics in the United States and Canada, Canada and Mexico, Indonesia and Canada is almost equivalent, especially for the United States, Canada and Mexico, whose domestic epidemics are with the same tendency; (iv) the COVID-19 epidemic has spread though not only the central divergence manner and chain mode of transmission, but also the way of feedback loop. Thus, more efforts should be made by the governments to enhance the pertinence and compulsion of their epidemic prevention policies and establish a systematic and efficient risk assessment mechanism for public health emergencies.
Green Growth, Green Technology, and Environmental Health: Evidence From High-GDP Countries
Authors: Hussain Zahid , Mehmood Bilal , Khan Muhammad Kaleem , Tsimisaraka Raymondo Sandra Marcelline
Published: January 2022

Green growth is an exceptional strategy for sustainable development. It provides a pathway to combat environmental issues and the use of natural resources. This study investigates the effects of green technology and environmental factors on green growth in high-gross domestic product (GDP) countries from 2000 to 2020. In addition, it also probes the linear and nonlinear effects of GDP on green growth. To do so, we employ an advanced econometric approach, e.g., a cross-sectional autoregressive distributed lags estimator for long and short runs. The outcomes demonstrate that the linear effect of GDP is positive for green growth. On the contrary, the nonlinear effect of GDP has a negative magnitude for green growth. Besides, green technology substantially increases green growth. Energy consumption is found to be an important influencer, and it decreases green growth. Environmental factors such as emissions, according to the findings, also reduce green growth in the sample countries. It is worth noting that the joint effects of energy consumption and emissions deteriorate green growth in countries. Based on empirical findings, for policy makers, this study suggests that high-GDP countries should manage their economic and environmental activities in order to increase the amount of green growth that may protect the ecological environment.
Prevalence and Determinants of Burnout Among Palliative Care Clinicians in Saudi Arabia
Authors: Ghazwani Eisa Yazeed
Published: January 2022

Background

Palliative care is in dire necessity than ever before due to aging populations and the prevalence of cancer and other chronic diseases associated with aging.

Objective

To assess the prevalence and risk factors associated with burnout among palliative care clinicians in Saudi Arabia.

Methods

A cross-sectional study conducted in 2018 covering all palliative care centers of Saudi Arabia and included 44 palliative care physicians (26 males and 18 females). The level of burnout was measured using Maslach Burnout Inventory's (MBI) 22 point scale questionnaire which assesses emotional exhaustion, depersonalization, and reduced personal accomplishment, the three dimensions of burnout syndrome. Pearson correlation and binary logistic analysis were performed using SPSS to find out factors influencing burnout considering P-value of <0.05 as significant.

Results

Eight participants (18.2%) had experienced emotional exhaustion and 11 (25%) had experienced depersonalization and detachment, and reduced personal accomplishment, each. Job title and availability of some administrative departments, supporting health care staff, and pain relief medications have shown significant impact of level of burnout. However, the prevalence of the burnout dimensions did not differ significantly according to the palliative care physicians' other characteristics.

Conclusions

This is amongst the first survey to assess the prevalence of burnout among palliative care physicians in Saudi Arabia. Although, some variables have shown significantly high level in the burnout domains, yet, the overall prevalence of burnout is low among palliative care physicians in Saudi Arabia. The availability of hospitals services such as administrative departments, supporting health care staff, and pain relief drugs have shown significant impact on burnout.
Physics-Informed Modeling and Control of Multi-Actuator Soft Catheter Robots
Authors: Ghoreishi Seyede Fatemeh , Sochol Ryan D. , Gandhi Dheeraj , Krieger Axel , Fuge Mark
Published: January 2022

Catheter-based endovascular interventional procedures have become increasingly popular in recent years as they are less invasive and patients spend less time in the hospital with less recovery time and less pain. These advantages have led to a significant growth in the number of procedures that are performed annually. However, it is still challenging to position a catheter in a target vessel branch within the highly complicated and delicate vascular structure. In fact, vessel tortuosity and angulation, which cause difficulties in catheterization and reaching the target site, have been reported as the main causes of failure in endovascular procedures. Maneuverability of a catheter for intravascular navigation is a key to reaching the target area; ability of a catheter to move within the target vessel during trajectory tracking thus affects to a great extent the length and success of the procedure. To address this issue, this paper models soft catheter robots with multiple actuators and provides a time-dependent model for characterizing the dynamics of multi-actuator soft catheter robots. Built on this model, an efficient and scalable optimization-based framework is developed for guiding the catheter to pass through arteries and reach the target where an aneurysm is located. The proposed framework models the deflection of the multi-actuator soft catheter robot and develops a control strategy for movement of catheter along a desired trajectory. This provides a simulation-based framework for selection of catheters prior to endovascular catheterization procedures, assuring that given a fixed design, the catheter is able to reach the target location. The results demonstrate the benefits that can be achieved by design and control of catheters with multiple number of actuators for navigation into small vessels.
A System Innovation Approach for Science-Stakeholder Interface: Theory and Application to Water-Land-Food-Energy Nexus
Authors: Alamanos Angelos , Koundouri Phoebe , Papadaki Lydia , Pliakou Tatiana
Published: January 2022

The Water-Food-Energy Nexus can support a general model of sustainable development, balancing resources with increasing economic/productive expectations, as e.g., in agriculture. We synthesise lessons from Greece's practical and research experience, identify knowledge and application gaps, and propose a novel conceptual framework to tackle these challenges. Thessaly (Central Greece), the country's driest region and largest agricultural supplier is used as an example. The area faces a number of water quantity and quality issues, ambitious production-economic objectives, continuous (historically) drought and flood events, conflicts, administrative and economic issues, under serious climate change impacts. A detailed assessment of the current situation is carried out, covering all these aspects, for the first time in an integrated way. Collaboration gaps among different stakeholders are identified as the biggest impediment to socially acceptable actions. For the first time, to our knowledge, the Nexus is set as a keystone to develop a novel framework to reverse the situation and achieve sustainable management under socially acceptable long-term visions. The proposed framework is based on Systems' Theory, innovation, uses a multi-disciplinary platform to bring together all relevant stakeholders, provides scientific support and commitment, and makes use of technological advances for the system's improvement.