bluuebunny/crossref_metadata_2025 huggingface dataset:
Agressividade, Negatividade e Afetividade: Revisitando o lado positivo de viver esses sentimentos - Aggressiveness, Negativity and Affectivity: Revisiting the positive side of experiencing these feelings
Authors: Paula Ana Silvia
Published: November 2023

Resumo: O presente artigo tem como objetivo principal desenvolver uma reflexão acerca dos conceitos de “agressividade” e “raiva” utilizando como metodologia a revisão bibliográfica de importantes teóricos, a exemplo de Alexander Lowen, David Boadella, Bennett Shapiro e W. Reich. Pretende-se problematizar e apontar a importância da agressividade e da raiva enquanto impulsos ordenadores e positivos para a elaboração e o crescimento do sujeito. Para isso, me utilizo também de exemplos clínicos para fundamentar meus apontamentos.  Palavras- Chave:  agressividade; raiva; análise bioenergética. Abstract: The present article has the purpose of developing a reflection concerning concepts of “aggressiveness” and “anger”, using as methodology literature review of leading theorists, such as Alexander Lowen, David Boadella, Bennett Shapiro and W. Reich. The aim is to problematize and point out the importance of aggressiveness and anger as positive and ordering impulses towards the preparation and development of the individual. Clinical examples are also used for the purpose of substantiating my accounts. Keyword: aggressiveness; anger; bioenergetic analysis.
Defining wilderness: the evolution of Banff National Park
Authors: Mayer Felix , Bernbaum Piper , Neuhaus Fabian , Robertson Natalie
Published: November 2023

Internationally, Canada is a country known for its iconic, expansive landscapes. Images of the Rocky Mountains and destinations such as Lake Louise and Banff are instantly recognisable, drawing visitors from around the world each year. Wilderness is a term that has become irrevocably linked to Canadian national identity and Canadian culture. Nowhere is the significance of wilderness within Canadian culture and history more visible than in the country’s vast network of provincial and national parks. This article explores the history of Canada’s oldest national park, Banff, and the creation and evolution of its boundaries. It explores how park boundaries act as spatial tools to project legal frameworks and cultural values, creating landscapes and an experience of place rather than simply preserving existing conditions or ecologies. The history of Banff National Park is also used to explore the broader implications that idealised or romanticised notions of wild spaces have had in shaping Canadian cultural values, which in turn have shaped attitudes towards landscapes and the defining of landscapes into industrialised zones and zones of conservation. Fundamentally an architectural study of site, this article explores the evolution of the national park boundaries of Banff through their interactions with industrial interests, cultural landmarks and historical narratives, dissecting their capacities to control intensely layered and contested areas. Through a study of the park boundary and the forces that have shaped it over time, the dynamics of power, exclusion, exploitation and commercialisation inherent to the definition of landscapes and boundaries are investigated.
Ethical and relational leadership in a complex world: the use of the Human Learning Systems and social pedagogical leadership framework to navigating complexity
Authors: Charfe Lowis
Published: November 2023

The Covid-19 pandemic brought into sharp focus the complexities and challenges facing social work and social care organisations. Using theory, ethics and practice, this article aims to critically explore an ethical and relational approach to leadership that can help navigate complexity in social work in the UK. Explaining the emerging Human Learning System, this article argues that this paradigm can offer an alternative to the new public management, with its focus on the three core aspects ofmarkets,matrixandmanagement. Key to this discussion is the social pedagogy leadership framework, which aims to assist the navigation of complexity in direct practice and support positive organisational cultures and systems as discussed within the Human Learning System. The leadership framework is informed by the principles of social pedagogy, which are seen as an ethical philosophical approach to leadership and direct practice. It places human relationships and rights within the everyday and at the heart of leadership and organisational change – as Berit Bae has stated, human rights must be applied in the everyday, not just in certain situations. Using the philosophical principles and core ideas of social pedagogy and the Human Learning System, the framework is designed to support leadership, which is relational and ethical at its core, while also assisting the navigation of uncertainty and the complexities of the work undertaken by modern social work and social care organisations.
Penerapan Jaringan Distribusi Sistem District Meter Area (DMA) SPAM Semarang Barat dalam Optimalisasi Penurunan Kehilangan Air Ditinjau dari Aspek Teknis dan Finansial (Studi Kasus : Area Pelayanan Reservoir Manyaran 1)
Authors: Buko Bagus Tri , Sarminingsih Anik , Samadikun Budi Prasetyo
Published: November 2023

Drinking water is one of basic human needs that is very important to  improve the quality of human life and economic growth of a region. PDAM Tirta Moedal, Semarang City developed “SPAM Semarang Barat”  1,000 liters/sec to serve water demand in West Semarang, Ngaliyan and Tugu sub-districts. Water losses in PDAM Kota Semarang is still at 40.10%, indicating that water distribution is not optimal. DMA is a strategy in managing water loss, especially real water loss, by dividing an open water supply network into isolated zones with smaller water meter. In this study, a technical and financial study was conducted regarding the implementation of DMA in the SPAM Semarang Barat distribution specifically for the Manyaran 1 Reservoir service area . The real water loss is caused by visible or invisible leakage of distribution pipes (background leakage). The billed authorized consumption is estimated at 4,189,607 m3/year, the unbilled authorized consumption is 7,361 m3/year. Apparent water loss is estimated at 147,455 m3/year or about 2%, while real water loss is around 2,172,896 m3/year or about 34%. The Infrastructure Leakage Index or ILI for the Manyaran 1 Reservoir distribution is 49. It means that PDAM is wasting some resource, which caused losses.  Epanet 2.0 shows that peak hours pressure is between 30 – 70 m, there is no pressure below 10 m. Velocity at peak hours is in the range of 0.1 – 1.0 m/s. The investment requirement for DMA development in the Manyaran 1 service area Rp. 18,786,292,828, - for development of services as much as 5,843 SR. District Meter Area in distribution system is estimated to reduce the leakage rate by up to 20%, so that the potential revenue will increase by Rp. 26,083,764,633,-. It means that DMA is one of ways to solve water leakage problem.
Aplikasi Metode GALDIT Untuk Analisis Kerentanan Airtanah Terhadap Intrusi Air Laut di Kabupaten Rembang, Jawa Tengah
Authors: Putranto Thomas Triadi , Santi Narulitas , Rizki Aldino Maulana , Martini Nestri
Published: November 2023

Groundwater is water that is found below the ground surface or in rock layers. Seawater intrusion is a problem caused by excessive groundwater extraction which often occurs in coastal areas. Rembang is an area located in the coastal area. Rembang Regency has the potential for seawater intrusion. The impact of seawater intrusion can affect economic, social and cultural development in coastal areas as well as the quantity and quality of groundwater. The purpose of this study is to determine areas that have potential for seawater intrusion in the study area. The methods were geological mapping, groundwater quality analysis, GALDIT approach and its validation using TDS, DHL and Chloride. The interpretation of the area that has the potential for seawater intrusion is carried out with validation in the research area. The results conducted that in the research area consists of limestone, sandstone, claystone, the presence of porphyry andesite and alluvium. Based on the analysis of the vulnerability of seawater intrusion using the GALDIT method, it was found that there are 3 levels of vulnerability, namely middle to very high vulnerability. High vulnerability has GALDIT index > 7.5, located on the north coast of Rembang and Kaliori sub-districts.. The high vulnerable is 5-7.5, located mostly in Kaliori and Rembang sub-districts, and a little in Sulang, Sumber, Bulu, and Gunem sub-districts. The middle vulnerable is in the range of 2.5-5 mostly in Bulu, Gunem, Sumber, Sulang sub-districts, and a little in Rembang and Kaliori sub-districts. The validation carried out has a high match in the north of the study area. The very high level of vulnerability is in accordance with the distribution of the population and the land use map where the Kaliori and Rembang sub-districts have a large population and the land use is filled with buildings and settlements.
Jasa Lanskap pada Pekarangan Transmigran Bali di Wilayah Lampung Timur
Authors: Ali Muhammad Saddam , Arifin Hadi Susilo , Nurhayati Nurhayati , Astawan Made
Published: November 2023

The transmigration home garden was one of the potential providers of landscape services, such as ecological, economic, social and cultural services. These landscape services can improve people's welfare. The Balinese transmigrant home garden in East Lampung became the research location to see the services of the home garden landscape. Ecological approaches, economic analysis, and socio-culture analysis were carried out to determine the role of the home garden in providing  landscape services. The Balinese transmigrant home garden pattern was built based on the Rwa Bhineda concept which regulates the layout of the building. The composition of pekarangan plants was analyzed using the vertical diversity, horizontal diversity, and Summed Dominance Ratio (SDR) values of the plants. In addition, it also analyzed economic services in the form of additional income and reduced costs for consumption. The results showed that several plants such as coconut, mango, banana, and flower ornamental plants had high SDR value up to 45%. These plants are used as a component of religious rites for the Balinese transmigrant community. Home garden also provided economic services, namely additional income and reduced consumption costs up to 100% per month/family. Home garden landscape services for Balinese transmigrants were proof that community welfare can be realized through sustainable use of home gardens and had implications for the achievement of transmigration goals.
Critical Level of Chromium for Rice in Different Soil Type
Authors: Zu'amah Hidayatuz , Sukarjo Sukarjo , Harsanti Elisabeth Srihayu , Apriyani Siska , Sulastri Baiq Nunung
Published: November 2023

The increasing number of industries and poor treatment of waste will damage environmental health, including agricultural land. Agricultural products from contaminated soil may contain hazardous heavy metals such as chromium which can be harmful to human health if consumed. Examination and determination of chromium critical level in paddy soil are required to evaluate the threshold of heavy metals to disable to distribute into paddy plants. This study aims to obtain the critical level of chromium in light and heavy textured soils with paddy as a plant indicator. The pot experiment was carried out at the greenhouse using a completely randomized design with two factors are heavy metal concentration (Cr) and soil texture (A) and five times repeated. The chromium adsorption test uses the Langmuir approach method.  Chromium sorption in heavy-textured soil is higher than in light-textured soil. The maximum sorption of chromium metal in light-textured soil is 87.719 mg kg-1, while in heavy-textured soil is 204.082 mg kg-1. Total chromium in the soil decreases after harvest and reduces rice yields. The critical level of light-textured soil chromium in rice was 0.861 mg kg-1, while the critical level for heavy-textured soil Chromium in rice was 1.012 mg kg-1.
Struktur Komunitas Ikan di Pantai Pasarbangi, Rembang
Authors: Muhammad Fuad , Muhandini Isti Karim , Putro Sapto Purnomo , Putranto Thomas Triadi
Published: November 2023

Ikan  memiliki  peranan  penting  baik secara ekologi maupun ekonomi. Ikan berperan di dalam siklus rantai makanan, dapat dijadikan sebagai bahan pangan dan komoditas objek wisata. Penelitian ini bertujuan untuk mengkaji struktur komunitas ikan di Pantai Pasarbangi Rembang. Penelitian dilakukan di 5 stasiun yang berbeda yaitu  daerah wisata, kawasan tambak, aliran sungai, sekitar mangrove, dan daerah laut yang mendekati komunitas terumbu karang. Ikan diambil menggunakan alat jaring ikan dan dogol. Pengambilan sampel di setiap stasiun dilakukan 3 kali pengulangan. Hasil penelitian diperoleh 22 jenis ikan yang termasuk dalam 16 famili. Indeks keanekaragaman jenis tergolong rendah dan sedang. Indeks kemerataan jenis tergolong rendah, sedang dan tinggi. Indeks dominansi tergolong rendah dan tinggi. Parameter fisik kimia perairan Pantai Pasarbangi seperti suhu, pH, salinitas, DO, kekeruhan dan TDS masih tergolong cocok kehidupan, sedangkan parameter kecerahan kurang menunjang kehidupan ikan.
Estimasi Karakteristik Sosial-Ekonomi Wilayah dalam Capaian Pembangunan Berkelanjutan untuk 100% Akses Sanitasi di Provinsi Kepulauan Riau
Authors: Tehupeiory Aarce , Sianipar Imelda Masni Juniaty , Sari Mega Mutiara , Septiariva Iva Yenis , Suhardono Sapta , Suryawan I Wayan Koko
Published: November 2023

Kebijakan capaian pembangunan berkelanjutan harus dipenuhi pada tahun 2030, salah satu capain tujuan pembangunan tersebut salah satunya adalah akses sanitasi yang layak untuk masyarakat. Masyrakat yang tinggal di kepulauan merupakah salah satu yang rentan karena sulitnya pembangunan infrastruktur dan mobilisasi. Salah satu wilayah kepulauan yang ada di Indonesia adalah Provinsi Kepulauan Riau yang berbatasan langsung dengan negara lain. Provinsi ini terbagi menjadi wilayah Karimun, Bintan, Natuna, Lingga, Kepulauan Anambas, Kota Batam, dan Kota Tanjungpinang. Studi ini dilakukan dengan menggunakan data sekunder dan diolah dengan menggunakan regresi liniear beganda. Adapaun variable yang digunakan dalam studi ini adalah waktu, waktu, pendapatan domestik reginal bruto (PDRB), dan indeks pembangunan manusia (IPM) sebagai variabel bebas. Sedangkan capaian akses sanitasi layak dari setiap tahunnya digunakan sebagai variabel terikat. Hubungan antara ketiga variable PDRB, IPM, dan waktu secara signifikan berkorelasi (p < 0.01) pada peningkatan akses sanitasi di Provinsi Kepulauan Riau. R-kuadrat dalam goodness-of-fit untuk model regresi linier dalam estimasi model akses sanitasi di Provinsi Kepulauan Riau menunjukkan nilai 0.837. Analisis Varians (ANOVA) terdiri menunjukkan tingkat variabilitas dalam model regresi linear memiliki p < 0.01. Pembangunan Berkelanjutan (SDG) yang berorientasi pada kesetaraan untuk 'akses universal dan adil ke sanitasi yang aman dan terjangkau untuk semua', dan 'sanitasi dan kebersihan yang memadai dan adil untuk semua' memerlukan pemantauan ketidaksetaraan secara teratur dapat diciptakan di wilayah kepulauan. Integrasi antara peningkatan ekonomi dan pembangunan manusia perlu dilakukan dalam memberikan lingkungan yang layak dan aman dari gangguan kesehatan. Selain memberikan tersebut juga secara tidak langsung pada keuntungan ekonomi melalui peningkatan kesehatan sehingga masyarakat semakin produktif.
Identifying 1-rectifiable measures in Carnot groups
Authors: Badger Matthew , Li Sean , Zimmerman Scott
Published: November 2023

We continue to develop a program in geometric measure theory that seeks to identify how measures in a space interact with canonical families of sets in the space. In particular, extending a theorem of M. Badger and R. Schul in Euclidean space, for an arbitrarylocally finite Borel measurein an arbitraryCarnot group, we develop tests that identify the part of the measure that is carried by rectifiable curves and the part of the measure that is singular to rectifiable curves. Our main result is entwined with an extension ofanalyst’s traveling salesman theorem, which characterizes the subsets of rectifiable curves inR2{{\mathbb{R}}}^{2}(P. W. Jones,Rectifiable sets and the traveling salesman problem, Invent. Math.102(1990), no. 1, 1–15), inRn{{\mathbb{R}}}^{n}(K. Okikiolu,Characterization of subsets of rectifiable curves inRn{{\bf{R}}}^{n}, J. London Math. Soc. (2)46(1992), no. 2, 336–348), or in an arbitrary Carnot group (S. Li) in terms of local geometric least-squares data calledJones’β\beta-numbers. In a secondary result, we implement the Garnett-Killip-Schul construction of a doubling measure inRn{{\mathbb{R}}}^{n}that charges a rectifiable curve in an arbitrarycomplete, doubling, locally quasiconvex metric space.
Problemzone Ostdeutschland
Authors: Barthold Willi Wolfgang
Published: November 2023

By analyzing Lukas Rietzschel’s novel Mit der Faust in die Welt schlagen (2018) and Nino (f.k.a. Paula) Bulling’s Comic Im Land der Frühaufsteher (2012), this article explores contemporary portrayals of “East German rural space” against the backdrop of current discourses on Germany’s postmigrant condition. Marginalized on a political, economic and symbolic level and construed as the “Other” of German majority society in mainstream media, the “rural East” has recently been discovered by artists as a medium to reflect on urbanormative and (post-)colonial structures of representation that shape the debate and discursive construction process of postmigrant realities. In order to further illuminate this unique position and potential of East German rural space in art and postmigrant discourse, this paper will explore issues of migration, belonging, and (East German) identity in the abovementioned works through the lens of postcolonial theory.
An Exploration of “Shadow Play”: An Analysis of the Origin of Chinese Film Aesthetics
Authors: Leilei Jia
Published: November 2023

Shadow play is the collective name of different forms of art performance such as “shadow puppets” (皮影戏, Piyingxi), “puppet play” (傀儡戏, Kuileixi), and so on. It is a folk art taught through practices and oral traditions, “creating shadows with light”, and came into being over two millennia ago. It emerged in different forms at different times and across different regions and cultures, thus the phrase can connote slightly different art forms depending on cultural context. Chinese people later used “shadow play” to refer to films introduced to China. Such usage not only addresses the connections between film and opera, but highlights how film inherited traditions of shadow play – telling stories through shadows.
Bonding and noncovalent interactions effects in 2,6-dimethylpiperazine-1,4-diium oxalate oxalic acid: DFT calculation, topological analysis, NMR and molecular docking studies
Authors: Medimagh Mouna , Ben Mleh Cherifa , ISSAOUI Noureddine , Raja Murugesan , Kazachenko Aleksandr S. , Al-Dossary Omar M. , Roisnel Thierry , Kumar Naveen , Marouani Houda
Published: November 2023

The pharmaceutical proprieties of the 2,6-dimethylpiperazine-1,4-diium oxalate oxalic acid compound have been studied and the relevant drug design has been considered. The investigated organic compound with formula (2,6-(CH3)C4H10N2)2(C2O4)2·H2C2O4 (2DPOA) has been synthesized by slow evaporation technique at room temperature of a molar ratio 3:2 mix of oxalic acid and 2,6-dimethylpiperazine. Then 2DPOA has been characterized by IR, 13C NMR, UV–visible and the DFT calculation at the B3LYP level of theory has been made. The molecular structure and parameters (bond angles and lengths) of the molecule have been optimized using the Gaussian 09 software and compared with the XRD data. The atoms-in-molecules (AIM), electron localization function (ELF), and localized orbital locator (LOL) methods have been utilized to determine the types and nature of noncovalent interactions present within the 2DPOA molecule. These methods offer insights into the characteristics and behavior of these interactions. Furthermore, the presence of these interactions has been confirmed through the Hirshfeld Surface (HS) and reduced density gradient (RDG) analysis. The NBO analysis is employed to assess the charge exchange occurring within the studied compound. The molecular reactive sites have been examined using the molecular potential surface and Mulliken atomic charges. The energy gap between HOMO–LUMO and chemical properties of 2DPOA have been determined within the frontier molecular orbital theory. The UV–Vis spectrum of the 2DPOA molecule has been recorded and examined. The calculated and experimental infrared absorption and nuclear magnetic resonance spectra of 2DPOA molecule have been investigated. Finally, the molecular docking simulation has been used to find novel inhibitors and drugs for the cancer and epilepsy disease treatment.
From Outbreak to Recovery: An Observational Analysis of the Romanian Government's Online Communication during and post-COVID-19
Authors: Tasente Tanase , Rus Mihaela , Tanase Georgiana
Published: November 2023

Introduction: The expanding digital era has transformed government communication, especially during crises like the COVID-19 pandemic. This study aims to comprehensively evaluate the digital communication strategies of the Romanian Government during the pandemic and its aftermath, emphasizing the importance of effective communication in times of crisis. Methodology: For this comprehensive analysis, quantitative and qualitative techniques were combined. Data were collected from Facebook using FanPageKarma.com and processed in RStudio. Key aspects were examined, including the categorization of communication phases, posting frequency, metrics of public interaction (comments and actions), and the analysis of the overall sentiment tone. Results: The findings reveal that during the COVID-19 crisis, the Romanian Government dedicated 42.3% of its 3,465 Facebook posts to the virus. This percentage significantly decreased to 1.46% after the crisis, indicating a thematic shift in government communication. Public engagement also decreased post-pandemic, with a shift towards global narratives, especially tension between Ukraine and Russia. The sentiment analysis shows an overwhelmingly positive language aimed at inspiring trust and hope. Conclusions: This study highlights that, following the COVID-19 crisis, the Romanian Government adapted its digital communication, experiencing lower public engagement but maintaining a positive tone. This underscores the importance of effective government communication during and after crises, a critical element for ensuring public trust and social cohesion. These findings offer valuable lessons for government communication management in times of uncertainty and emphasize the need for continuous adaptation in a constantly evolving digital world.
Polypathologic Associations with Gray Matter Atrophy in Neurodegenerative Disease
Authors: Phillips Jeffrey S. , Robinson John L. , Cousins Katheryn A. Q. , Wolk David A. , Lee Edward B. , McMillan Corey T. , Trojanowski John Q. , Grossman Murray , Irwin David J.
Published: November 2023

Mixed pathologies are common in neurodegenerative disease; however, antemortem imaging rarely captures copathologic effects on brain atrophy due to a lack of validated biomarkers for non-Alzheimer’s pathologies. We leveraged a dataset comprising antemortem MRI and postmortem histopathology to assess polypathologic associations with atrophy in a clinically heterogeneous sample of 125 human dementia patients (41 female, 84 male) with T1-weighted MRI ≤ 5 years before death and postmortem ordinal ratings of amyloid-${\bi \beta }$, tau, TDP-43, and${\bi \alpha }$-synuclein. Regional volumes were related to pathology using linear mixed-effects models; approximately 25% of data were held out for testing. We contrasted a polypathologic model comprising independent factors for each proteinopathy with two alternatives: a model that attributed atrophy entirely to the protein(s) associated with the patient’s primary diagnosis and a protein-agnostic model based on the sum of ordinal scores for all pathology types. Model fits were evaluated using log-likelihood and correlations between observed and fitted volume scores. Additionally, we performed exploratory analyses relating atrophy to gliosis, neuronal loss, and angiopathy. The polypathologic model provided superior fits in the training and testing datasets. Tau, TDP-43, and${\bi \alpha }$-synuclein burden were inversely associated with regional volumes, but amyloid-${\bi \beta }$was not. Gliosis and neuronal loss explained residual variance in and mediated the effects of tau, TDP-43, and${\bi \alpha }$-synuclein on atrophy. Regional brain atrophy reflects not only the primary molecular pathology but also co-occurring proteinopathies; inflammatory immune responses may independently contribute to degeneration. Our findings underscore the importance of antemortem biomarkers for detecting mixed pathology.
Low-Frequency Stimulation of Trpv1-Lineage Peripheral Afferents Potentiates the Excitability of Spino-Periaqueductal Gray Projection Neurons
Authors: Brewer Chelsie L. , Kauer Julie A.
Published: November 2023

High-threshold dorsal root ganglion (HT DRG) neurons fire at low frequencies during inflammatory injury, and low-frequency stimulation (LFS) of HT DRG neurons selectively potentiates excitatory synapses onto spinal neurons projecting to the periaqueductal gray (spino-PAG). Here, in male and female mice, we have identified an underlying peripheral sensory population driving this plasticity and its effects on the output of spino-PAG neurons. We provide the first evidence that Trpv1-lineage sensory neurons predominantly induce burst firing, a unique mode of neuronal activity, in lamina I spino-PAG projection neurons. We modeled inflammatory injury by optogenetically stimulating Trpv1+ primary afferents at 2 Hz for 2 min (LFS), as peripheral inflammation induces 1–2 Hz firing in high-threshold C fibers. LFS of Trpv1+ afferents enhanced the synaptically evoked and intrinsic excitability of spino-PAG projection neurons, eliciting a stable increase in the number of action potentials (APs) within a Trpv1+ fiber-induced burst, while decreasing the intrinsic AP threshold and increasing the membrane resistance. Further experiments revealed that this plasticity required Trpv1+ afferent input, postsynaptic G protein-coupled signaling, and NMDA receptor activation. Intriguingly, an inflammatory injury and heat exposurein vivoalso increased APs per burst,in vitro. These results suggest that inflammatory injury-mediated plasticity is driven though Trpv1+ DRG neurons and amplifies the spino-PAG pathway. Spinal inputs to the PAG could play an integral role in its modulation of heat sensation during peripheral inflammation, warranting further exploration of the organization and function of these neural pathways.
Cholinergic Activation of Corticofugal Circuits in the Adult Mouse Prefrontal Cortex
Authors: Gulledge Allan T.
Published: November 2023

Acetylcholine (ACh) promotes neocortical output to the thalamus and brainstem by preferentially enhancing the postsynaptic excitability of layer 5 pyramidal tract (PT) neurons relative to neighboring intratelencephalic (IT) neurons. Less is known about how ACh regulates the excitatory synaptic drive of IT and PT neurons. To address this question, spontaneous excitatory postsynaptic potentials (sEPSPs) were recorded in dual recordings of IT and PT neurons in slices of prelimbic cortex from adult female and male mice. ACh (20 µM) enhanced sEPSP amplitudes, frequencies, rise-times, and half-widths preferentially in PT neurons. These effects were blocked by the muscarinic receptor antagonist atropine (1 µM). When challenged with pirenzepine (1 µM), an antagonist selective for M1-type muscarinic receptors, ACh instead reduced sEPSP frequencies, suggesting that ACh may generally suppress synaptic transmission in the cortex via non-M1 receptors. Cholinergic enhancement of sEPSPs in PT neurons was not sensitive to antagonism of GABA receptors with gabazine (10 µM) and CGP52432 (2.5 µM) but was blocked by tetrodotoxin (1 µM), suggesting that ACh enhances action-potential-dependent excitatory synaptic transmission in PT neurons. ACh also preferentially promoted the occurrence of synchronous sEPSPs in dual recordings of PT neurons relative to IT–PT and IT–IT parings. Finally, selective chemogenetic silencing of hM4Di-expressing PT, but not commissural IT, neurons blocked cholinergic enhancement of sEPSP amplitudes and frequencies in PT neurons. These data suggest that, in addition to selectively enhancing the postsynaptic excitability of PT neurons, M1 receptor activation promotes corticofugal output by amplifying recurrent excitation within networks of PT neurons.
An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions
Authors: Radzisheuskaya Aliaksandra , Peña‐Rømer Isabel , Lorenzini Eugenia , Koche Richard , Zhan Yingqian , Shliaha Pavel V , Cooper Alexandra J , Fan Zheng , Shlyueva Daria , Johansen Jens V , Hendrickson Ronald C , Helin Kristian
Published: November 2023

Efficient treatment of acute myeloid leukemia (AML) patients remains a challenge despite recent therapeutic advances. Here, using a CRISPRi screen targeting chromatin factors, we identified the nucleosome‐remodeling factor (NURF) subunit BPTF as an essential regulator of AML cell survival. We demonstrate that BPTF forms an alternative NURF chromatin remodeling complex with SMARCA5 and BAP18, which regulates the accessibility of a large set of insulator regions in leukemic cells. This ensures efficient CTCF binding and boundary formation between topologically associated domains that is essential for maintaining the leukemic transcriptional programs. We also demonstrate that the well‐studied PHD2‐BROMO chromatin reader domains of BPTF, while contributing to complex recruitment to chromatin, are dispensable for leukemic cell growth. Taken together, our results uncover how the alternative NURF complex contributes to leukemia and provide a rationale for its targeting in AML.
Prospectivas de la nueva ley que regula los consultorios jurídicos y los centros de conciliación en Colombia, Ley 2113 de 2021
Authors: Cortés Zambrano Sonia Patricia
Published: November 2023

El Ministerio de Justicia y del Derecho, en cooperación con las universidades y los consultorios jurídicos del país, promovió una ley que entró en vigencia en junio de 2021, cuyo objeto es establecer el marco normativo mediante el cual se regulan las prácticas de los consultorios jurídicos de las instituciones de educación superior. Este artículo relaciona los principales cambios legislativos y pone de relieve las nuevas exigencias para las universidades en su doble misión, la de formar y la de prestar un servicio social.
Religión y cultura, factores determinantes en las relaciones internacionales: Irán, país teocrático
Authors: Parada Julieth Astrid , Velásquez Natalia Sofía
Published: November 2023

Las relaciones internacionales son una disciplina que ha estado presente desde que iniciaron las comunicaciones entre los Estados y está conformada por varios factores, entre los cuales la religión y la cultura juegan un papel fundamental. Con base a esta afirmación, se realizó un estudio que evidencia lo determinantes que son ambos factores en las rrii. Se tomó como caso de estudio la República Islámica de Irán, único Estado islámico actual instaurado debido a una revolución popular, donde el ámbito sociopolítico se ve afectado por estos y otros factores de vital importancia. La investigación se realizó extrayendo información de fuentes secundarias, la cual fue organizada y analizada, para aportar al área de conocimiento de las rrii. Así mismo, se realizó una revisión de literatura de las temáticas fundamentales de la disciplina, se expuso y explicó el caso de estudio abordado y, por último, se generó una discusión que proporcionó conclusiones objetivas.
Qualidade do Ensino e Avaliações em Larga Escala no Brasil: Os Desafios do Processo e do Sucesso Educativo na Garantia do Direito à Educação
Authors: Cardoso de Araújo Gilda , Falco Reis Fernandes Caroline
Published: November 2023

Este artigo visa discutir sobre a qualidade do ensino e as avaliações em larga escala no Brasil e sobre seus desafios do processo e do sucesso educativo na garantia do direito à educação. Para isso, num primeiro momento, abordou-se o tema da qualidade do ensino em sua relação com o direito à educação. Num segundo momento, realizamos uma trajetória da avaliação em larga escala no Brasil, o seu processo de implantação e consolidação, bem como a configuração atual da avaliação nas políticas educacionais brasileiras, especificamente, o Índice de Desenvolvimento da Educação (IDEB). Concluímos que a intensificação com sobreposição dos testes em larga escala não incidem sobre a análise de processos educativos e fatores escolares que podem conduzir políticas de melhoria da qualidade.Palabras chave: Qualidade, IDEB, avaliação. This article aims to discuss the quality of teaching and assessments on a large scale in Brazil and its challenges on the process and the educational success in guaranteeing the right to education. To do this, at first, we dealt with the issue of quality education in its relationship with the right to education. Second, we conducted a path of large-scale evaluation in Brazil, the process of implementation and consolidation, as well as the current configuration of evaluation in Brazilian educational policies, specifically, the t Índice de Desenvolvimento da Educação (IDEB). We conclude that with increasing overlap of large-scale testing does not focus on the analysis of educational processes and school factors that can lead to policy improvement.Keywords: Quality, IDEB, evaluation.
Desarrollo de la Competencia Matemática a través de Programas para Aprender a Aprender en la Infancia Temprana
Authors: Salmerón Honorio , Gutiérrez-Braojos Calixto , Salmerón Purificación
Published: November 2023

La Ley Orgánica de Educación determina una serie de competencias básicas para generar una educación de calidad. Para ello es necesario el desarrollo de materiales curriculares que faciliten al profesorado la enseñanza en la adquisición de tales competencias. La finalidad de este estudio fue aplicar materiales didácticos construidos al efecto para el área de matemáticas que faciliten estrategias para aprender a aprender y favorezcan la mejora de la competencia matemática, específicamente la resolución de problemas. El estudio empírico se establece a partir de un diseño pretest con un postest y dos grupos, uno control que sigue los materiales tradicionales y otro experimental con un entrenamiento en estrategias para aprender a aprender en la resolución de problemas matemáticos. El contexto de investigación es un centro educativo de España, específicamente en la provincia de Cádiz. La muestra está compuesta por 48 participantes que cursan Primero de Primaria, esto es, alumnado en edad temprana. Los resultados indican que el material didáctico utilizado por el grupo experimental, facilita la apropiación de estrategias para aprender a aprender y la competencia matemática, específicamente la subcompetencia en resolución de problemas en mayor medida que el material tradicional empleado en el grupo control.Palabras clave: Educación primaria, competencia matemática, competencia para aprender a aprender, estrategias de aprendizaje. The Basic Education Law determines a number of skills Basic to generate a quality education. It is requires to develop curricular materials that provide teachers with the teaching of such skills. The purpose of this study was to observe the cognitive development and metacognitive which is generated by the students, implemented in their regular curriculum, a program of learning strategies with materials developed ad hoc for the development of skills cognitive learning to learn competence and mathematics using the area of mathematics. The empirical study, with 2 groups (control group and experimental group), have a design pretest - postest. The context of research was a school in Spain (Cádiz). The sample was 48 students enrolled in the first course of the primary school. The results indicate that this didactic material develops learn to learn skills and mathematics skill more and earlier in the experimental group than in the control group.Keywords: Primary school, math skills, learning to learn skills, strategies learning, math area.
Las Tecnologías y la Enseñanza en la Educación Superior. El caso de USINA como Herramienta de Autor
Authors: Lion Carina , Soletic Ángeles , Jacubovich Jimena , Gladkoff Lucía
Published: November 2023

En el contexto actual, la innovación didáctica en el nivel superior viene asociada a la creación de herramientas de autor, es decir, aplicaciones digitales originales que den la posibilidad de potenciar las prácticas de enseñanza considerando la interrelación entre la especificidad disciplinar, el desarrollo tecnológico y la construcción metodológica. El artículo propone analizar un entorno creado recientemente por el Centro de Innovación en Tecnología y Pedagogía (CITEP) de la Universidad de Buenos Aires. La herramienta digital, llamada  USINA, fue diseñada para la enseñanza y el aprendizaje a través de simulaciones con el propósito de enriquecer el proceso formativo de los estudiantes de la Universidad propiciando el análisis, la resolución de problemas, la relación entre teoría y práctica, la transferencia de los aprendizajes a nuevas situaciones y contextos.Palabras clave: Enseñanza mediada por tecnologías, herramienta de autor, simulador, toma de decisiones, prácticas profesionales. Nowadays, didactic innovations in higher education are associated to authoring tools, i.e., original digital applications that allow for teaching practice improvements, taking into account the interrelation between field specificity, technological development, and methodological construction. The article looks into an environment recently created by the Center for Innovation of Technology and Pedagogy (Centro de Innovación en Tecnología y Pedagogía, CITEP) at the University of Buenos Aires. The digital tool, called USINA, was designed for teaching and learning through simulations with the purpose of enriching University students’ learning process by encouraging analysis, problem solving, theory-practice relations, and transfer to new situations and contexts.Keywords: Technology mediated education, author’s tools, simulator, decision making, professional practice.
Innovación Educativa sobre Aprendizaje Colaborativo con CmapTools en la Formación Inicial Docente
Authors: Pontes Alfonso , Serrano Rocío , Muñoz Juan Manuel , López Isabel
Published: November 2023

Entre las principales destrezas que debería desarrollar actualmente el profesorado durante el proceso de formación inicial, podemos destacar el uso educativo de las Tecnologías de la Información y la Comunicación (TIC), el trabajo en equipo y la capacidad para reflexionar sobre el propio conocimiento. Para colaborar al desarrollo de tales aspectos hemos llevado a cabo un proyecto de innovación docente donde los estudiantes de magisterio aprenden a realizar mapas conceptuales individuales y grupales, con ayuda de CmapTools. Este software es libre y útil para integrar de forma práctica las TIC en el proceso educativo, ya que permite desarrollar una metodología activa, en la que se fomenta al mismo tiempo el aprendizaje reflexivo y el trabajo en equipo. Tras analizar los datos recogidos hemos observado que los futuros maestros muestran opiniones positivas sobre las estrategias y recursos empleados en esta experiencia, valorando especialmente el proceso de aprendizaje colaborativo desarrollado en el aula.Palabras clave: Innovación educativa, formación inicial del profesorado, mapas conceptuales, aprendizaje colaborativo, CmapTools. Among the main skills that teachers must acquire nowadays in the process of initial training, we should highlight the educational use of Information and Communication Technologies (ICT), teamwork and the ability to reflect his own knowledge. In order to collaborate to the development of such aspects we have carried out a project of educational innovation, where the teaching student learn to make concept maps individually and in groups , using CmapTools. This software is free and useful in order to integrate ICT of practical form in the educational process, as it allows the development of an active methodology while promoting the reflexive learning and the teamwork. After analyzing the collected data we have found that the future teachers show positive opinions about the strategies and resources used in this experience, especially appreciating the process of collaborative learning in the classroom.Keywords: Educational innovation, initial teacher training, collaborative learning, concept maps, CmapTools.
Pilates system as a method of kinesiotherapy for kyphotic posture
Authors:   Kharkiv State Academy of Physical Culture, Shelikhova Valeriia , Kalmykova Yuliya ,   Kharkiv State Academy of Physical Culture
Published: November 2023

Kyphotic posture is a deformity of the spine, characterized by a large curvature of the thoracic spine. Kyphosis not only spoils the figure, but also leads to the development of serious pathologies that negatively affect the quality of life. Objective: to study Pilates as a method of kinesiotherapy for kyphotic posture. Material and methods: to assess the effectiveness of physical therapy for kyphotic posture by Pilates with variations used the following research methods: history, examination, functional tests and scales (Tomayer test, finger-floor test; scales: visually analog scale, Oss. Results: Positive dynamics in kinesiotherapy was in both groups, but in the main indicators were better by several positions.Conclusions: the use of Pilates with variations showed significant positive dynamics in the performance of ErGo clients from the control group
THE UN AND UKRAINIAN DIPLOMACY IN THE STRUGGLE FOR INDEPENDENCE AND TERRITORIAL INTEGRITY OF UKRAINE IN THE CONTEXT OF THE RUSSIAN-UKRAINIAN WAR
Authors:   Institute of History of Ukraine, the National Academy of Sciences of Ukraine, 4, Mykhailo Hrushevskyi Street, Kyiv, 01001, Ukraine, Vidnyanskyj Stepan
Published: November 2023

The article highlights the activities of the United Nations and the UN Security Council during the Russian-Ukrainian war of 2014-2023 and the activity of Ukrainian diplomacy in defending Ukraine's independence and territorial integrity. The author analyses, in particular, the voting processes at the UN General Assembly and Security Council meetings on issues related to the Russian aggression against Ukraine and points out their ineffectiveness. The author emphasises the need to reform all UN activities in accordance with the current challenges of the global world in the context of the formation of a new, multipolar system of international relations. Particular attention is paid to the acute problem of transforming the most influential body of the United Nations - the Security Council, its structure and decision-making mechanisms, which have been based on the principle of division into permanent and non-permanent members since 1945. The principle of division into permanent and non-permanent members and veto power for the former - the United States, the USSR (and today its illegal successor, the Russian Federation), the People's Republic of China, France and the United Kingdom - no longer corresponds to current realities, as the exclusive possession of veto power by the leading players in world politics is a direct violation of the principle of equality of UN member states. The article also examines the active work of the Ministry of Foreign Affairs of Ukraine during the Russian war against Ukraine. It is not only about the realisation of the complex current tasks of expanding an effective pro-Ukrainian coalition in the world, restoring universal respect for the UN Charter and the equal rights of independent states and peoples, but also about the prospects for post-war arrangements in Europe and the world with Ukraine's active participation. It is concluded that Ukrainian diplomacy, in the difficult conditions of martial law and the crisis of the UN and the entire international security system, is quite adequately fulfilling its responsible mission of protecting Ukraine's national interests in the modern global world.
PUBLIC DIPLOMACY IN THE ACTIVITIES OF THE FIRST LADY (on the Example of Ukraine and Poland)
Authors:   Institute of History of Ukraine, the National Academy of Sciences of Ukraine, 4, Mykhailo Hrushevskyi Street, Kyiv, 01001, Ukraine, Matiash Iryna ,   Centre for East European Studies, University of Warsaw, 26/28, Krakowskie Przedmieście Street, Warsaw, 00-927, the Republic of Poland
Published: November 2023

The purpose of the study is to identify the peculiarities of the First Lady's activities in the field of public diplomacy on the example of Ukraine and Poland. The research methodology is based on the principles of scientificity, historicism, systematicity, and general scientific and specialised methods, including the biographical method. The scientific novelty of the research results lies in raising the issue of the institution of the First Lady as a subject of public diplomacy and analysing the activities of the First Ladies of Ukraine and Poland in this area. Conclusions: Based on the activities of the First Ladies of Ukraine and Poland, it can be argued that Agata Kornhauser-Duda and Olena Zelenska have changed the perception of the role of presidential wives in the development of public diplomacy. Despite the first mentions of public diplomacy in the late nineteenth century, the testing of its tools in the first half of the twentieth century, active involvement in academic and professional use began in the second half of the twentieth century, and in Ukraine in the twenty-first century. Elements of public diplomacy can be seen in the activities of the wives of the first persons of Ukraine and Poland during the struggle for statehood: Maria Hrushevska, Aleksandra Piłsudska, Olha Petliura, and Michalina Mościcka. They created the historical basis for the use of public diplomacy tools by First Ladies. The modern First Ladies of Ukraine and Poland in addition to their traditional duties have mastered the tools of public diplomacy to create a positive image of their countries in the minds of other countries. The use of this toolkit gained particular importance with the outbreak of Russia's large-scale war against Ukraine and, in fact, the entire civilised world on 24 February 2022. Agata Kornhauser-Duda and Olena Zelenska demonstrate that the First Lady's Institute belongs to the public diplomacy community.