bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Utilization of Vacant Houses and Extraction of Regional Characteristics Using Travel Information Data
Authors: Sasaki Aoto , Morisaki Yuma , Fujiu Makoto
Published: August 2024

The number of vacant houses in Japan has increased rapidly in recent years due to a declining population. The government has been actively developing measures to solve the vacant house problem and has implemented subsidy programs to support the expansion of vacant house utilization projects. Japan has a particularly high number of vacant houses that are utilized for the purpose of “tourism”. However, vacant house utilization projects are scattered across Japan, and information on such projects is lacking. Moreover, the correlation between different vacant house utilization projects and their location characteristics has not been investigated. In this study, we used a travel information website to extract vacant house utilization facilities from the locations listed and determined the location characteristics of the utilization facilities. We classified the extracted utilization facilities into different categories and used the k-means method to group vacant house utilization facilities according to their categories and regional characteristics. The results obtained in this study can help local governments and businesses implement appropriate location-specific utilization projects.
Applications of Novel Combined Controllers for Optimizing Grid-Connected Hybrid Renewable Energy Systems
Authors: Menzri Fatima , Boutabba Tarek , Benlaloui Idriss , Chrifi-Alaoui Larbi , Alkuhayli Abdulaziz , Khaled Usama , Mahmoud Mohamed Metwally
Published: August 2024

Hybrid renewable energy systems (HRES) integrating solar, wind, and storage technologies offer enhanced efficiency and reliability for grid-connected applications. However, existing control methods often struggle with maintaining DC voltage stability and minimizing power fluctuations, particularly under variable load conditions. This paper addresses this research gap by proposing a novel control strategy utilizing a PD (1+PI) regulator that combines proportional–integral (PI) and proportional–derivative (PD) controllers. Integrated into the HRES with maximum power point tracking (MPPT), the system includes solar panels, a storage unit, and a wind system featuring a permanent magnet synchronous generator (PMSG). The PD (1+PI) regulator plays a critical role in stabilizing DC voltages within the storage system and collaborates with predictive direct power control (P-DPC) to improve current quality by mitigating fluctuations in active and reactive power. Comparative analysis against traditional direct power control methods shows that the proposed strategy reduces voltage fluctuation by 30% and improves energy utilization efficiency by 25%, validating its efficacy in managing energy from diverse sources to meet nonlinear load demands. The results demonstrate that integrating the PD (1+PI) regulator with MPPT and P-DPC approaches enhances power stability and optimizes energy utilization in grid-connected HRES, underscoring the effectiveness of this advanced control system.
Service System Design of a Community-Shared Medicine Station
Authors: Li Ruohui , Li Rui , Lin Ruoshuang
Published: August 2024

Increasing health awareness has led to a rise in household medication storage, but problems of medication waste and expired medication contamination have been highlighted. We conducted in-depth interviews and developed user personas to comprehensively analyse users’ drug storage behaviours and motivations. Using a semiotic approach to product architecture design and the analytic hierarchy process (SAPAD-AHP) model, we explored core user needs. Additionally, we identified improper disposal of expired medication at home as a significant environmental issue. We propose a community-shared medicine service model aimed at reducing medication waste and pollution through sharing and recycling resources. This model enhances the utilisation of medical equipment, offers users convenient and eco-friendly health services, and promotes sustainable development.
Recognising Ecological Reflexivity: An Alternative Approach to Partnership Capabilities for Collaborative Governance
Authors: Stanberry Joanna , Murphy David F. , Balda Janis Bragan
Published: August 2024

Ecological reflexivity provides a key lever for the implementation of the Sustainable Development Goals (SDGs) but is underexplored in one prominent context: collaborative governance particularly associated with SDG 17. Using an exploratory study and novel approach to Q methodology, we investigate capabilities needed for advancing collaborative governance and cross-sector partnering through an exploratory study. Rather than treating these capacities as universal standards or aims for collaboration between varied stakeholders, they were offered as options that actors may value and choose to advance (or not). Local sustainability-focused actors in North West England sorted capabilities as statements, which discursively reframe multi-stakeholder partnership (MSP) building blocks. The first analysis reveals three viewpoints that we name: The Convener, The Connector, and The Chair. The themes of communicative coordination, reflexivity, and power emerged in the three viewpoints, expressing distinct discourses. A separate, second analysis explores a viewpoint encompassing capabilities needed for ecological reflexivity. Our findings demonstrate possible barriers to some approaches valued in the MSP literature such as systems thinking. Finally, in our action research setting, it is possible that the methodology itself facilitated ecological reflexivity and offered entry points to enable agency in the context of SDG 17 and collaboration of diverse actors towards SDG implementation.
Can New Infrastructure Become a New Driving Force for High-Quality Industrial Development in the Yellow River Basin?
Authors: Ma Wei , Yang Tingyi
Published: August 2024

Ecological protection and high-quality development in the Yellow River Basin have become a major national strategy in China. This paper explores the impact and mechanisms of new infrastructure on high-quality industrial development in the Yellow River Basin, considering the current context of vigorous development of new infrastructure and the industrial development status of the region. This study finds that new infrastructure promotes high-quality industrial development in the Yellow River Basin, and the enhancement of digital literacy strengthens this positive impact. New infrastructure facilitates high-quality industrial development in the Yellow River Basin by driving labor transfer from the supply side and consumption upgrading from the demand side. This positive influence is particularly pronounced in the upstream cities, central cities, and urbanized areas of the Yellow River Basin. Further research indicates that there is a “pain period” in promoting the construction of new infrastructure, and only when the level of high-quality industrial development exceeds a certain threshold can its efficiency be further improved. The conclusions of this paper provide theoretical references and policy inspiration for the coordinated promotion of new infrastructure construction to empower high-quality industrial development in the Yellow River Basin.
Severe Attrition and Poor Satisfaction in Patients Undergoing Telerehabilitation vs. Standard In-Person Rehabilitation after Arthroscopic Rotator Cuff Repairs and Anterior Cruciate Ligament Reconstructions
Authors: Vasavada Kinjal D. , Shankar Dhruv S. , Avila Amanda , Mojica Edward S. , Hurley Eoghan T. , Lehane Kevin , Buzin Scott D. , Oeding Jacob F. , Stein Spencer M. , Gonzalez-Lomas Guillem , Alaia Michael J. , Strauss Eric J. , Jazrawi Laith M. , Campbell Kirk A.
Published: August 2024

Background: The use of telerehabilitation after sports medicine procedures such as an arthroscopic rotator cuff repair (ARCR) and anterior cruciate ligament reconstruction (ACLR) has rapidly increased in recent years; however, the functional outcomes and patient satisfaction with telerehabilitation compared to in-person rehabilitation remain unclear. The purpose of this study was to compare the functional outcomes and patient satisfaction with telerehabilitation to in-person rehabilitation in a randomized controlled trial after two common sports procedures, ARCR and ACLR. Methods: Two randomized controlled trials were conducted involving patients scheduled to undergo ARCR or ACLR by one of six fellowship-trained sports medicine surgeons between October 2020 and November 2021. Each trial had an enrollment goal of 60 patients. Subjects were randomized 1:1 to receive telerehabilitation or in-person rehabilitation postoperatively. Functional outcome and satisfaction metrics were collected at baseline and at post-operative visits and compared between groups. Results: In total, 16 ACLR patients were enrolled, of whom 10 (62.5%) were assigned to in-person rehabilitation and 6 (37.5%) to telerehabilitation. Additionally, 32 ARCR patients were enrolled, of whom 20 (62.5%) were assigned in-person rehabilitation and 12 (37.5%) were assigned telerehabilitation. In total, of the 30 patients assigned to in-person rehabilitation, none reported a crossover to telerehabilitation. Of the 18 patients initially assigned to telerehabilitation, 12 (67%) completed the final follow-up survey, of which 11 (92%) reported a crossover; 9 patients completed in-person rehabilitation and 2 patients completed hybrid in-person and telerehabilitation. Conclusions: Patients preferred in-person rehabilitation compared to telerehabilitation after ACLR and ARCR, as evidenced by the nearly ubiquitous crossover from telerehabilitation to in-person rehabilitation in both studies. Our findings suggest that telerehabilitation protocols still need to be perfected, and that there may be a role for a hybrid in-person and tele-rehab model.
Effect of Fin Type and Geometry on Thermal and Hydraulic Performance in Conditions of Combined-Cycle Nuclear Power Plant with High-Temperature Gas-Cooled Reactors
Authors: Ramadan Khaled A. A. , Slyusarskiy Konstantin V.
Published: August 2024

One method of nuclear energy development involves using helium. Its properties make using extended surfaces obligatory. However, currently nuclear technology does not typically use finned tubes. This study explores ways of enhancing heat transfer efficiency in a high-temperature gas-cooled reactor system by using novel fin designs in the heat exchanger for residual heat removal. Four different types of fins were studied: annular, serrated, square, and helical. The effect of fin height, thickness, and number was evaluated. Serrated and helical fins demonstrated superior performance compared to conventional annular fin designs, which was expressed in enhanced efficiency. The thickness of fins was found to have the strongest influence on the efficiency, while the height and number of fins per meter had weaker effects. In addition, the study emphasized the significance of considering complex effects when optimizing fin design, like the effect of fin geometry on the velocity of helium. The findings highlight the potential of creative fin designs to greatly enhance the efficiency and dependability of gas-cooled reactor systems, opening up possibilities for advancements in nuclear power plant technology.
T Cell Responses during Human Immunodeficiency Virus/Mycobacterium tuberculosis Coinfection
Authors: Bohórquez José Alejandro , Jagannath Chinnaswamy , Xu Huanbin , Wang Xiaolei , Yi Guohua
Published: August 2024

Coinfection with Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) is a significant public health concern. Individuals infected with Mtb who acquire HIV are approximately 16 times more likely to develop active tuberculosis. T cells play an important role as both targets for HIV infection and mediators of the immune response against both pathogens. This review aims to synthesize the current literature and provide insights into the effects of HIV/Mtb coinfection on T cell populations and their contributions to immunity. Evidence from multiple in vitro and in vivo studies demonstrates that T helper responses are severely compromised during coinfection, leading to impaired cytotoxic responses. Moreover, HIV’s targeting of Mtb-specific cells, including those within granulomas, offers an explanation for the severe progression of the disease. Herein, we discuss the patterns of differentiation, exhaustion, and transcriptomic changes in T cells during coinfection, as well as the metabolic adaptations that are necessary for T cell maintenance and functionality. This review highlights the interconnectedness of the immune response and the pathogenesis of HIV/Mtb coinfection.
Permeability Estimation of Engineering-Adapted Clay–Gravel Mixture Based on Binary Granular Fabric
Authors: Huang Wenbin , Chen Chenghao , Chen Shengshui , Ling Hua , Mei Shiang , Tang Yi
Published: August 2024

Clay–gravel mixture is an increasingly popular material used in geotechnical engineering for its engineering adaptability and easy accessibility. Among various granulometric factors, gravel content plays a critical role in the alteration of mixture microstructure. Its influence on mechanical behavior has been comprehensively investigated, yet the hydraulic models accounting for the paired impact of clay and gravel particles are seldomly discussed. In an effort to enhance the permeability prediction capability of this soil, a generalized binary model derived from a theoretical hydraulic conductivity expression is proposed, with the participation of two fundamental compound seepage models. High accuracy between test and calculation results indicates the reliability of this model, as well as its supremacy over conventional models. The parameter sensitivity analysis demonstrates that the proposed model, being of convincing parametric stability regardless of variant particle size distribution characteristics, has the potential to be applicable to a wide range of engineering-adapted CGMs. The predictive formula for cohesive fraction and the anomaly coefficient, as is integrated into the binary model, are explicitly discussed. Suitable for clay–gravel materials under a transitional soil state for engineering applications, this model provides a quantitative and reasonable evaluation of hydraulic conductivity with high practicality. The above findings might work as a perspective for the credible assessment of structure seepage safety behavior, as well as a quantitative evaluation method regarding the mixing quality of CGMs.
Hydrological Monitoring System of the Navío-Quebrado Coastal Lagoon (Colombia): A Very Low-Cost, High-Value, Replicable, Semi-Participatory Solution with Preliminary Results
Authors: Nardini Andrea Gianni Cristoforo , Escobar Villanueva Jairo R. , Pérez-Montiel Jhonny I.
Published: August 2024

Like many coastal lagoons in several countries, the “Navío Quebrado” lagoon (La Guajira, Colombia) is a very delicate and precious environment; indeed, it is a nationally recognized Flora and Fauna Sanctuary. Several factors, including climate change, are threatening its existence because of changes in the governing hydro-morphological and biological processes. Certainly, the first step to addressing this problem is to understand its hydrological behavior and to be able to replicate, via simulation, its recent history before inferring likely futures. These potential futures will be marked by changes in the water input by its tributary, the Camarones River, and by modified water exchange with the sea, according to a foreseen sea level rise pattern, as well as by a different evaporation rate from the free surface, according to temperature changes. In order to achieve the required ability to simulate future scenarios, data on the actual behavior have to be gathered, i.e., a monitoring system has to be set up, which to date is non-existent. Conceptually, designing a suitable monitoring system is not a complex issue and seems easy to implement. However, the environmental, socio-cultural, and socio-economic context makes every little step a hard climb. An extremely simple—almost “primitive”—monitoring system has been set up in this case, which is based on very basic measurements of river flow velocity and water levels (river, lagoon, and sea) and the direct participation of local stakeholders, the most important of which is the National Park unit of the Sanctuary. All this may clash with the latest groovy advances of science, such as in situ automatized sensors, remote sensing, machine learning, and digital twins, and several improvements are certainly possible and desirable. However, it has a strong positive point: it provides surprisingly reasonable data and operates at almost zero additional cost. Several technical difficulties made this exercise interesting and worthy of being shared. Its novelty lies in showing how old, simple methods may offer a working solution to new challenges. This humble experience may be of help in several other similar situations across the world.
Interpreting Controls of Stomatal Conductance across Different Vegetation Types via Machine Learning
Authors: Xue Runjia , Zuo Wenjun , Zheng Zhaowen , Han Qin , Shi Jingyan , Zhang Yao , Qiu Jianxiu , Wang Sheng , Zhu Yan , Cao Weixing , Zhang Xiaohu
Published: August 2024

Plant stomata regulate transpiration (T) and CO2 assimilation, essential for the water–carbon cycle. Quantifying how environmental factors influence stomatal conductance will provide a scientific basis for understanding the vegetation–atmosphere water–carbon exchange process and water use strategies. Based on eddy covariance and hydro-metrological observations from FLUXNET sites with four plant functional types and using three widely applied methods to estimate ecosystem T from eddy covariance data, namely uWUE, Perez-Priego, and TEA, we quantified the regulation effect of environmental factors on canopy stomatal conductance (Gs). The environmental factors considered here include radiation (net radiation and solar radiation), water (soil moisture, relative air humidity, and vapor pressure deficit), temperature (air temperature), and atmospheric conditions (CO2 concentration and wind speed). Our findings reveal variation in the influence of these factors on Gs across biomes, with air temperature, relative humidity, soil water content, and net radiation being consistently significant. Wind speed had the least influence. Incorporating the leaf area index into a Random Forest model to account for vegetation phenology significantly improved model accuracy (R2 increased from 0.663 to 0.799). These insights enhance our understanding of the primary factors influencing stomatal conductance, contributing to a broader knowledge of vegetation physiology and ecosystem functioning.
IMPLEMENTATION OF PEDAGOGICAL CONDITIONS FOR THE IMPLEMENTATION OF A PERSONALLY-ORIENTED APPROACH TO THE EDUCATION OF MORAL-VOLUNTARY QUALITIES IN DIFFICULT ADOLESCENTS IN EXTRA-SCHOOL PHYSICAL ACTIVITIES
Authors: TARANENKO I. , ZAITSEVA Yu.
Published: August 2024

The article highlights the results of an experimental study on the effectiveness of pedagogical conditions for the implementation of a personally oriented approach to the education of moral and volitional qualities in difficult teenagers in extracurricular physical activity. Pedagogical conditions are based on the conceptual principles of systemic, person- oriented, environmental, sports-oriented, activity-oriented and cultural approaches and consist of the following: 1) involvement of difficult teenagers in public organizations of physical culture and sports orientation; 2) ensuring the psychological and methodical readiness of trainers to educate difficult teenagers with moral and volitional qualities; 3) the use of innovative personally oriented forms and methods of educating moral and volitional qualities of difficult teenagers.
The comparative analysis of the results of research and experimental work showed a significant increase in the number of teenagers with a sufficient level of upbringing of moral and volitional qualities - from 7.7% to 30.7%, and a significant decrease (by 44.2%) of a low level - from 61.5% up to 17.3%. The reliability of the obtained data was confirmed by the method of variational statistics according to the homogeneity criterion (Pearson's criterion).
CURRENT PROBLEMS OF PHYSICAL EDUCATION AND WAYS OF IMPROVING THE PROFESSIONAL TRAINING OF FUTURE TEACHERS OF PHYSICAL EDUCATION
Authors: DENYSOVETS T. , KVAK O. , GOGOTS V.
Published: August 2024

The article examines and theoretically analyzes the factors that indicate the need to rebuild the system of physical education in higher education institutions with a focus on the personality, needs, and health of students of higher education, with the use of motivational approaches and incentives.
The concept of the content of work, which is defined by the tasks facing educational institutions at a certain stage of their development, as well as the state of educational work and the level of qualification of the pedagogical staff of each specific educational institution and the level of competence of the organizers of the educational process, is interpreted.
The main features of fitness technologies in education are determined, which increase the level of traditional physical culture, provide positive emotions, satisfy human needs by strengthening his health, forming a positive and active attitude to a healthy lifestyle, success and prosperity, a modern lifestyle, contribute to the development motility of students, improve physical development and physical training.
The article established that the competent and purposeful introduction of fitness technologies into the system of physical culture classes for the health, development and education of currently studying youth is one of the main and urgent tasks of modernizing curricula and work programs of higher education institutions.
RECREATION AND REHABILITATION TECHNOLOGIES IN PHYSICAL CULTURE AND SPORTS: WAYS OF IMPROVING BODY FUNCTIONING
Authors: ZHARA H. , DOVBYSH S.
Published: August 2024

In this article, the authors explore a wide range of methods and strategies aimed at improving the functioning of the body. Various aspects of physical rehabilitation, physical recreation, therapeutic physical culture and approaches to preserving and improving health, physical form, and mental state of a person are analysed.
The main emphasis is pointed on recreational and rehabilitation technologies, which include a variety of methods, exercises and procedures aimed at restoring the body's functions after injuries, diseases or operations, as well as maintaining and improving physical and mental well-being.
Special attention is paid to an individual approach to each patient and the development of complex rehabilitation programs that take into account all the peculiarities of functioning in accordance with the International Classification of Functioning, Disability and Health (ICF), the existing nosology, and the personalized needs of each person.
The study includes an analysis of current trends in physical culture and sports, an overview of physical rehabilitation methods, and highlighting innovative approaches to a healthy lifestyle and improving the quality of life in general. In particular, the article discusses various methods of exercises and procedures that contribute to the restoration and maintenance of the body's health. The authors draw attention to how these methods can be effective for patients after  various types of injuries, operations or diseases. The study also includes an analysis of innovative approaches to a healthy lifestyle, in particular, in the context of increasing physical activity, achieving optimal motor capacity and psychological well- being.
Important aspects and promising areas of further research are the developments of individual programs that help people achieve their goals in maintaining and improving health. This article is a valuable source of information for professionals in the fields of medicine, public health, physical rehabilitation, and sports, as well as anyone interested in healthy living and improving the quality of life in general.
O uso pedagógico de softwares educativos e educacionais como ferramentas de melhoria no ensino de Matemática
Authors: Ribeiro Isaias , David José Maria , Braga Regina
Published: August 2024

Este artigo discute sobre o uso de softwares educativos e educacionais como recursos pedagógicos no ensino da Matemática nos Anos Finais do Ensino Fundamental. O estudante contemporâneo precisa utilizar os recursos tecnológicos disponíveis na sociedade para construir seus conhecimentos. Nesse contexto, defende-se que a tecnologia, mais especificamente aquela voltada especialmente para a educação, tende a potencializar o ensino de Matemática ajudando os alunos a superarem dificuldades nessa disciplina. É um recurso que pode atrair os estudantes para o aprendizado escolar, o que tem sido uma tarefa complicada nos tempos atuais, em que os alunos vivem em um universo praticamente paralelo e digital, enquanto as aulas, de uma forma geral, ainda não são tão interessantes quanto os jogos eletrônicos. Assim, esta pesquisa destaca a importância de reformular os objetivos, conteúdos e metodologias de ensino para atender às necessidades da sociedade atual. A metodologia do estudo é descrita como uma pesquisa qualitativa que se baseia em uma revisão de uma seleção específica de literatura. Os softwares em questão podem estimular os alunos, sendo uma alternativa didática alinhada à Base Nacional Comum Curricular. Também são mencionados o papel do lúdico no ensino da Matemática e a importância das analogias presentes nos softwares educativos e educacionais. É enfatizada a importância de considerar a realidade em que os estudantes estão inseridos, bem como suas habilidades no uso de softwares educacionais, adequando a proposta pedagógica a cada caso.
Chamelea gallina from the Black Sea (Bulgaria) as a sustainable source of macronutrients and fat-soluble vitamins
Authors:   Medical University of Varna, Department of Chemistry, 84 Tzar Osvoboditel Blvd., 9000 Varna, Bulgaria, Merdzhanova A. , Dobreva D. A. ,   Medical University of Varna, Department of Chemistry, 84 Tzar Osvoboditel Blvd., 9000 Varna, Bulgaria, Panayotova V. ,   Medical University of Varna, Department of Chemistry, 84 Tzar Osvoboditel Blvd., 9000 Varna, Bulgaria, Peycheva K. ,   Medical University of Varna, Department of Chemistry, 84 Tzar Osvoboditel Blvd., 9000 Varna, Bulgaria, Hristova T. ,   Medical University of Varna, Department of Chemistry, 84 Tzar Osvoboditel Blvd., 9000 Varna, Bulgaria, Stancheva R. ,   Medical University of Varna, Department of Chemistry, 84 Tzar Osvoboditel Blvd., 9000 Varna, Bulgaria
Published: August 2024

Marine bivalves are characterized as highly nutritional, easily digestible food, low in calories but high in proteins. Seafood nutrition data is useful for assessing the contribution to nutrient intake and for to the development of dietary guidelines. The aim of the present study is to determine the chemical composition: crude proteins, total lipids, carbohydrates, energy value and fat-soluble vitamins in white sand clam (Chamelea gallina). The samples were harvested from the Bulgarian coast of the Black Sea in the summer and autumn periods. Crude protein, carbohydrates and total lipids were determined using standard procedures. The fat-soluble vitamins were analysed simultaneously using highperformance liquid chromatography with ultraviolet and fluorescence detectors (HPLC-UV/FL). Analysed samples were characterised by high protein (16.4±0.2 to 18.2±0.1 g.100g-1 ww) and low lipid content (2.26±0.06 to 2.67±0.13 g.100 g - 1 ww). Lipid levels showed greater variations compared to proteins. Carbohydrates varied between 1.72 and 2.85 g.100g1 ww and the energy values – between 99.3 and 101.3 kcal.100g-1 ww. Higher amounts of all-trans retinol, cholecalciferol and vitamin K were found in the autumn samples, whereas α-tocopherol content decreased from summer to autumn. The present study reveals new data on the chemical composition of C. gallina harvested from the Bulgarian Black Sea coast. Despite the variations in their composition, C. gallina clams could be a healthy choice of low energy dense food due to high protein and fat-soluble vitamin levels and low lipid, carbohydrate and calorie contents.
Cullin 3/with No Lysine [K] Kinase/Ste20/SPS-Related Proline Alanine Rich Kinase Signaling: Impact on NaCl Cotransporter Activity in BP Regulation
Authors: Omage Kingsley , McCormick James A.
Published: August 2024

The sodium chloride cotransporter (NCC) fine-tunes Na+ balance and indirectly affects the homeostasis of other ions including K+, Mg2+, and Ca2+. Owing to its effects on Na+ balance, BP is significantly affected by alterations in NCC activity. Several factors have been reported to influence the expression and activity of NCC. One critical factor is NCC phosphorylation/dephosphorylation that occurs at key serine-threonine amino acid residues of the protein. Phosphorylation, which results in increased NCC activity, is mediated by the with no lysine [K] (WNK)-SPS–related proline alanine rich kinase (SPAK)/OSR1 kinases. NCC activation stimulates reabsorption of Na+, increasing extracellular fluid volume and hence BP. On the other hand, proteasomal degradation of WNK kinases after ubiquitination by the Cullin 3-Kelch-like 3 E3 ubiquitin ligase complex and dephosphorylation pathways oppose WNK-SPAK/OSR1-mediated NCC activation. Components of the Cullin 3/Kelch-like 3–WNK-SPAK/OSR1 regulatory pathway may be targets for novel antihypertensive drugs. In this review, we outline the impact of these regulators on the activity of NCC and the consequent effect on BP.
Hyperkalemia and Risk of CKD Progression: A Propensity Score–Matched Analysis
Authors: Agiro Abiy , Cook Erin , Mu Fan , Greatsinger Alexandra , Chen Jingyi , Zhao Angela , Louden Elaine , Colman Ellen , Desai Pooja , Chertow Glenn M.
Published: August 2024

Key Points

Hyperkalemia is a known complication of CKD; however, it is not known whether hyperkalemia directly contributes to CKD progression and risk of death.

We found that patients with stages 3b/4 CKD and hyperkalemia had higher risk of CKD progression and death than matched patients without hyperkalemia.

Background

Hyperkalemia is a known complication of CKD; however, it is not known whether hyperkalemia directly contributes to CKD progression and the risk of death. Clarifying the extent to which hyperkalemia is associated with CKD progression and mortality can inform clinical practice and guide future research. The objective of this study was to quantify the risks of CKD progression and mortality associated with hyperkalemia in patients with stages 3b/4 CKD.

Methods

This was a real-world, exact and propensity score matched, observational cohort study using data (January 2016 to December 2021) from Optum's deidentified Market Clarity Data, a large US integrated insurance claims/electronic medical record database. The study included matched adult patients with stages 3b/4 CKD with and without hyperkalemia, not regularly treated with an intestinal potassium (K+) binder. Measured outcomes were CKD progression and all-cause mortality. CKD progression was defined as diagnosis of CKD stage 4 (if stage 3b at index), CKD stage 5 or kidney failure, or receipt of dialysis or kidney transplantation.

Results

After matching, there were 6619 patients in each of the hyperkalemia and nonhyperkalemia cohorts, with a mean follow-up time of 2.12 (SD, 1.42) years. Use of any renin-angiotensin-aldosterone system inhibitors during baseline was common (75.9%), and most patients had CKD stage 3b (71.2%). Patients with hyperkalemia had a 1.60-fold (95% confidence interval, 1.50 to 1.71) higher risk of CKD progression and a 1.09-fold (1.02 to 1.16) higher risk of all-cause mortality relative to patients without hyperkalemia. Relative risks of CKD progression associated with hyperkalemia were similar within the subset of patients receiving renin-angiotensin-aldosterone system inhibitor, across CKD stages, and when alternative definitions of CKD progression were used.

Conclusions

Patients with CKD stages 3b/4 and hyperkalemia experienced significantly higher risks of CKD progression and all-cause mortality than propensity score matched patients without hyperkalemia.
Do Campus Incubation Centres Provide A Successful Linkage Between Early-stage Entrepreneurial Ventures And The Irish Institutes Of Technology?
Authors:   ,   Cork Institute of Technology, Fox Fiona
Published: August 2024

"This study is an examination of the issues that are pertinent to the development of linkages, which campus incubation centres provide between their host Institutes of Technology (loT) and their tenant firms. This research incorporates the views, opinions and recommendations of new firm entrepreneurs, campus incubation centre management, senior academic staff and researchers. This study responds to the lacuna of research on campus incubators hosted by the Institutes of Technology. This study confirms that campus business incubators that are affiliated to the loTs are still in their infancy. The research acknowledges that these campus incubators are in a ‘startup’ phase and consequently the findings of this research affirm that collaboration between the Institutes of Technology and their campus incubation companies is relatively low. The author has selected a qualitative method of research to seek the opinions, perceptions and attitudes of participants in this study in order to gain an in-depth understanding of activities, behaviours, concepts and their interrelationships. A significant finding of this research is that the interests and objectives of the early-stage ventures and the academic staff are heterogeneous. Another important finding of this research is that there is a complex trade-off in terms of the needs of the academic researchers and those of the emerging entrepreneurial firms. The research illustrates that what is advantageous for the academic researchers may not necessarily benefit the incubation company. Conflict may arise due to issues with industry or market oriented concerns. The findings of this research highlight the relationship between the Institute of Technology staff, the campus incubation centre and its incubatees. This relationship is predominantly an informal process, driven particularly, by individuals who are pro-active in seeking collaborative opportunities. An important finding of this research is the perspective and differing views between the researchers and the incubation staff as to the effectiveness of the research process for early-stage entrepreneurial ventures. This study will benefit stakeholders in the field such as policy-makers within an academic and incubator context and innovative entrepreneurs. Further research is warranted with regard to the remaining Institutes of Technology and Universities that host campus incubation centres, as this data would yield important and relevant information on the success of policy driven linkages."
Customer Satisfaction : The Case Study Of A Service Company
Authors:   ,   Cork Institute of Technology, Ilkme Emre
Published: August 2024

"This research was undertaken in Derichebourg Multi services to gain an understanding of customer satisfaction. Customer satisfaction and improving the customer service are important as this serves to create loyal customers in the business, since market competition has increased. If a company fails to respond to the customer needs and expectations, the satisfaction will not be provided and so customers will lose loyalty to the company and may eventually change the companies altogether. Thus, the importance of customer satisfaction and related subjects has been highlighted in this research. Satisfaction causes have been identified and the recommendations made to increase the customer satisfaction for Derichebourg Multiservices. To understand customer satisfaction in a service company, the researcher interviewed eight different Derichebourg Multiservices clients. The majority of the clients emphasized that they feel loyal to the company if they receive good customer service and they are satisfied with the service. The results show that service companies who deliver a good service create satisfied customers, leading to a greater customer loyalty. This can be achieved by implementing strong supervision, on-time delivery of the products and transparency in invoicing. It has been also concluded that by improving the customer service, a positive impact has been made on customer satisfaction and the development of customer loyalty, while they are using the company services."
CHARACTERISTICS OF CAUSATIVE AGENTS OF SURGICAL WOUND INFECTIONS IN MEDICAL INSTITUTIONS
Authors: Atakişizadə S.A. , Cəfərova K.Ə. , Kərimova İ.A. , Qurbanova L.M.
Published: August 2024

Məqalədə cərrahi yara infeksiyalarının etioloji agentlərinin və onların antimikrob preparatlara həssaslıq və rezistentliyinin araşdırılması məqsədilə aparılmış tədqiqat işi haqqında məlumat verilmişdir. Tədqiqat 2019-2022-ci illərdə Azərbaycan Tibb Universitetinin Tədris Cərrahiyyə klinikasında müalicə almış xəstələr üzərində aparılmışdır. Cərrahi əməliyyatlardan sonra baş verən yara infeksiyaları zamanı yara, drenaj və abses möhtəviyyatların mikrobioloji müayinəsi nəticəsində cərrahi yara infeksiyalarının əsas törədicilərinin S.aureus, P.aeruginosa, E.coli, Klebsiella cinsli bakteriyalar, eləcə də Candida cinsli göbələklər olduğu müəyyən edilmişdir. P.aeruginosa, E.coli vəKlebsiella cinsli bakteriyalar əksər antibiotiklərə davamlı olması ilə fərqlənmişlər. E.coli və Klebsiella cinsli bakteriya ştammlarının əksəriyyətində genişlənmiş spektrli betalaktamaza (GSBL), P.aeruginosa ştammlarının təqribən yarısında induksiya olunan beta-laktamaza (İsBL) produksiyası aşkar edilmişdir.

The article presents the results of a study conducted to investigate the etiological agents of surgical wound infections, their sensitivity, and resistance to antimicrobial agents. The study was carried out on patients who received surgical treatment at the clinic of Azerbaijan Medical University from 2019 to 2022. Microbiological examination of the contents of wounds, drains, and abscesses in wound infections that occurred after surgical operations was conducted. The study found that the main causative agents of surgical wound infections are S. aureus, P. aeruginosa, E. coli, Klebsiella, as well as Candida fungi. P. aeruginosa, E. coli, and Klebsiella are resistant to most antibiotics. Extended-spectrum beta-lactamase production was identified in most bacterial strains of E. coli and Klebsiella, while inducible beta-lactamase production was determined in approximately half of the P. aeruginosa strains.

В статье представлена результаты исследования, проведённого с целью изучения этиологических агентов хирургических раневых инфекций, их чувствительности и резистентности к антимикробным препаратам. Исследование было проведено у больных, получавших хирургическое лечение в клинике Азербайджанского медицинского университета в 2019-2022 гг. Проводили микробиологическое исследование содержимого ран, дренажей и абсцессов при раневых инфекциях, возникших после хирургических операций. В результате исследования установлено, что основными возбудителями хирургических раневых инфекций являются S.aureus, P.aeruginosa, E.coli, Klebsiella, а также грибы Candida. P.aeruginosa, E.coli и Klebsiella устойчивы к большинству антибиотиков. Продукция бета-лактамаз расширенного спектра была определена у большинства бактериальных штаммов E.coli и Klebsiella, а продукция индуцибельной бета-лактамазы (ИБЛ) была определена примерно у половины штаммов P.aeruginosa.
Media Edukasi Sebagai Pengenalan Tentang Domba Garut
Authors: Fitri Ledy Maharani , Andreas Rio Adriyanto  , Jiwa Utama
Published: August 2024

Indonesia dikenal dengan keindahan dan keunikan budayanya yang menjadi salah satu daya tarik wisatawan untuk mengunjungi Indonesia. Di Jawa Barat, khususnya Kabupaten Garut terkenal dengan suasan asri nya dan memiliki potensi wisata GURILAPS (Gunung, Rimba, Laut, Pantai, Seni). Garut memiliki ikon dari salah satu hewan ternak di Indonesia bernama domba garut. Meski domba garut tidak asing istilahnya bagi masyarakat, tidak semua orang memiliki akses informasi yang memadai mengenai domba garut lebih jelasnya. Dalam era pendidikan 4.0, teknologi informasi dan media edukasi menjadi penting untuk mengatasi keterbatasan ini. Hal ini sejalan dengan UU No. 5 Tahun 2017 tentang Pemajuan Kebudayaan, yang menekankan pentingnya perlindungan dan pemanfaatan budaya sebagai identitas dan kekayaan bangsa. Penelitian ini bertujuan untuk merancang media edukasi berbasis motion graphic yang mudah diakses dimanapun dan kapanpun, guna memperkenalkan dan melestarikan pengetahuan tentang domba garut ke masyarakat khususnya Generasi Z. Generasi Z adalah generasi yang kehidupannya lebih berdampingan dengan internet dan sosial media. Menggunakan metode penelitian kualitatif dalam mengumpulkan data yang dibutuhkan, menggunakan uji validitas data menggunakan triangulasi data, dan menggunakan metode double diamond framework untuk perancangannya. Diharapkan informasi tentang domba garut dapat tersebar luas dan dipahami oleh masyarakat, khususnya Generasi Z, melalui hasil dari penelitian dan perancangan ini
Percepción de la noción de cultura de paz en la Universidad Autónoma Indígena de México
Authors: Romero-Castro María del Rosario
Published: August 2024

Conflicts and violence are elements that are immersed in the multiple spaces where human beings coexist and interrelate. Both one and the other have been present throughout the history of humanity, which is why many experts have studied and proposed various ways to resolve them, through the use of methods in accordance with their nature. Although this phenomenon is multifactorial, one of the causes is that people do not have the necessary knowledge or skills to reach an agreement when there is a contradiction between the interests and objectives of individuals or groups. For this reason, national and international organizations such as the Secretaría de Educación Pública (SEP) and UNESCO recommend that educational strategies that promote the construction of a culture for peace for a creative approach to conflicts be included in the school curriculum, in various school contexts. The objective of the study is to identify the perception that students have about the attitudes that are related to the practice of the culture of peace. The results show that the students of the Universidad Autónoma Indígena de México (UAIM), Unidad Mochicahui, mostly affirm that active listening, dialogue and respect for the environment are attitudes that favor a culture of peace. The applied methodology has a mixed approach. The results were achieved through the application of a survey to a sample of 167 students of the sixth semester, and by conducting interviews with the coordinators of the educational programs.
Estrategias agroalimentarias sostenibles como respuesta al deterioro ambiental en el territorio de la Frailesca, Chiapas, México
Authors: Ruiz-González Rosey Obet
Published: August 2024

Currently, ecosystems are very deteriorated and large amounts of agrochemicals are applied to food for human consumption, which causes environmental and health problems in the society that consumes a diet based on food with agrochemicals, so a process of reflection-action about the use of agroecosystem services and build sustainable agrifood strategies in agricultural production systems. Agroecosystems constitute domesticated production units and interaction of all its components to generate flows of matter and energy. The sustainable appropriation of agroecosystems generates a healthy production of food that will improve people's health and protect the environment. The objective of the study was to identify and analyze sustainable agri-food strategies in the Frailesca region, Chiapas in the face of environmental deterioration of biosphere ecosystems. Through tours with instruments of geographic information systems, surveys and semi-structured interviews, we worked with peasant families that develop agroecological practices. The information obtained was organized, systematized and analyzed in Microsoft Access and the SAS version 27 software. Four sustainable strategies developed by peasant families, who use various agroecological fertilizers for production in the four micro-regions of the municipality of Villaflores, were identified and analyzed. Of the strategies mostly practiced by peasant families, there is corn interspersed with fruit trees, family gardens and agrosilvopastoral systems.
Aportes de un CA a estudiantes normalistas, con énfasis en la metodología multigrado
Authors: Sariñana Roacho Santa Edén , Sariñana Roacho Vianey
Published: August 2024

El presente ensayo desglosa elementos a considerar desde el trabajo de un Cuerpo Académico (CA), relacionado con las intervenciones docentes que llevan a cabo los estudiantes normalistas de la Escuela Normal Rural “J. Guadalupe Aguilera”, que cursan la Licenciatura en Educación Primaria (LEP).

El enlace del CA, estudiantes y la metodología multigrado, se retoma para reflexionar y analizar, puesto que, si un CA logra adentrarse en la temática, es posible diseñar propuestas de intervención, en aras de que los alumnos normalistas se desempeñen de mejor manera al momento de cumplir con sus prácticas docentes, asimismo, se les proveen de diversas herramientas para el trabajo en grupos multigrado.

Se pretende reflexionar las ventajas que existen al momento de apropiarse de esta forma de trabajo, misma que si se lograra implementar en toda la educación primaria, sin importar si se es unigrado o multigrado, los resultados emanados serían muy distintos. Uno de los aspectos más importantes a tomar en cuenta para el trabajo con metodología multigrado, entre varios, se pueden mencionar a las necesidades, contextos y habilidades que posee cada alumno.

Es importante rescatar lo antes plasmado, porque se presentan expresiones tal vez trilladas, por lo que hace falta investigación que permita generar propuesta al respecto, dejando de privilegiar la repetición o mecanización, se debe enfocar en generar, proponer, discutir, proyectar; lo anterior mediante el trabajo colaborativo, permitiendo que se fortalezcan los lazos de confianza y seguridad en la función docente en una escuela formadora de docentes.
Los equipos de investigación en las escuelas normales: Una experiencia hacia la conquista de un perfil PRODEP y retos profesionales
Authors: Madrigal Bueno Georgina , Cázares López José Pilar , Ontiveros Calderón Aida Esperanza
Published: August 2024

Develar indicadores presentes en los contextos que conduzcan a un planteamiento razonado que abra puertas acertadas a los grupos de investigación sobre las exigencias académicas del hacer pedagógico del formador de docentes en el contexto de la nueva escuela mexicana y la demanda profesional e investigativa de las Instituciones de Educación Superior (IES) para arribar al reconocimiento del Perfil Deseable del Programa para el Desarrollo Profesional Docente (PRODEP), es la inquietud plasmada en este ensayo académico. En su contenido, se hace un esfuerzo por compartir experiencias de un grupo de investigación de la Escuela Normal de Sinaloa (ENS) con la meta de arribar al perfil PRODEP, dificultades y retos en un contexto normativo complejo. La autoreflexión y análisis sistemático documental con alcance descriptivo de acciones dadas en el proceso de este reconocimiento, se basa en la recopilación de datos generales de los Cuerpos Académicos (CA) de las escuelas normales que dan cabida a propuestas de automejora y mejora institucional normativa.