bluuebunny/crossref_metadata_2025 huggingface dataset:
Влияние разбалансировки запорной арматуры на эксплуатацию трубопроводов
Authors: Хайруллина А.М.
Published: August 2023

В данной статье затронута тема влияния разбалансировки запорной арматуры на эксплуатацию трубопроводов. Рассматриваются функциональное назначение арматуры и область ее применения, также описаны основные этапы проверки исправности трубопроводной арматуры и основные признаки разбалансировки системы. При разбалансировке необходимо применение определенных методов настройки системы, которые также описаны в статье и сделаны выводы о том, как это влияет на эксплуатацию трубопроводов.
Становление судебной системы независимого Кыргызстана
Authors: Атамкулова Е.Т , Шакирова К.А
Published: August 2023

Значительные общественно-политические и социально-экономические изменения, произошедшие в Кыргызской Республике за последние годы, становление демократического правового государства, направление на присоединение к международным конвенциям по защите прав человека и основных свобод потребовали реформирования судебной системы Кыргызстана как одна из неотложных задач государственного устройства. Исследования истоков становления судебной системы независимого Кыргызстана позволяет, раскрыт наиболее существенные моменты его становления.
Использование метода анализа (расщепления) при разрешении межотраслевых коллизий в праве
Authors: Беличенко А.В.
Published: August 2023

В статье обосновывается необходимость использования метода анализа (расщепления) при разрешении межотраслевых коллизий в праве. С помощью этого метода в правовом положении лица, которое находится одновременно под регулирующим воздействием норм двух отраслей права, производится выделение обязанностей и прав, установленных одной и другой отраслью права. Такой анализ (расщепление) позволяет правильно разрешать межотраслевые коллизии
Проблемы регистрации наименования места происхождения товара в отношении товара «минеральная вода»
Authors: Бойко Т.В
Published: August 2023

В настоящей статье рассмотрена актуальная проблема, заключающаяся в невозможности регистрации наименования места происхождения товара в отношении товара «минеральная вода», в связи с несоответствием положений нормативно-правовых актов Российской Федерации
Некоторые вопросы института частного обвинения в Кыргызской Республике
Authors: Жусупов Б.А , Эшбаева Б.А
Published: August 2023

В статье проведен анализ актуальных вопросов правовой регламентации частного обвинения в уголовно процессуальном законодательстве Кыргызской Республики. Обобщены современные тенденции развития нормативного регулирования института частного обвинения
Method for obtaining supramolecular complex based on 3-ohypyridine derivatives and its application for correction of osteoporosis
Authors: Trunov Konstantin S.
Published: August 2023

Introduction: Currently, there are no safe and ideal medicines for the prevention and treatment of oophorectomy-induced osteoporosis. The development of an effective pharmacotherapy for hypoestrogen-induced osteoporosis is an important task of pharmacology.
Materials and Methods: A new supramolecular complex (composition №1) was obtained on the basis of 3-hydroxypyridine derivatives: 2-ethyl-6-methyl-3-hydroxypyridinium 3-pyridinocarbonoate and 2-ethyl-6-methyl-3-hydroxypyridinium N-acetyl-6-aminohexanoate in a ratio of 1:3 by topochemical synthesis. The study of the osteoprotective activity of the supramolecular complex at a dose of 50 mg/kg was performed on 60 white female rats of the Wistar line on a model of hypoestrogen-induced osteoporosis. The effectiveness of the osteoprotective activity of the complex was evaluated on the 57th day of the experiment.
Results and Discussion: The new supramolecular complex (composition №1) has osteoprotective activity, which is expressed in improving the indicators of X-ray and histomorphological samples. Oral administration of composition №1 at a dose of 50 mg/kg led to an increase in bone density to values of 2.55±0.02 g/cm3, which is 1.3 times higher than in the control group 1.92±0.01 g/cm3 (p≤0.05) and reduce bone resorption by improving cortical and trabecular bone structures.
Conclusion: The obtained data characterize the prospects of studying composition №1 for the correction and prevention of hypoestrogen-induced osteoporosis.
Graphical Abstract
Territorios de Convergencia entre Ciencia y Diseño
Authors: Strycek Ludmila
Published: August 2023

Este trabajo argumenta acerca de los territorios comunes que existen entre el campo de la ciencia y el campo del diseño. Burgos e Ibarra (2015)
Presentación
Authors: Bello Knoll Susy Inés
Published: August 2023

Por cuarto año consecutivo la Facultad de Diseño y Comunicación de la Universidad de Palermo en alianza estratégica con la Facultad de Derecho de la Universidad de Salamanca con fines de investigación continúan en la línea de análisis de Derecho y Diseño trabajando interdisciplinariamente en el marco de la protección y sustentabilidad del diseño.
Visiones del Diseño V. Diseño y Antropoceno: Desafíos sostenibles, resilientes y regenerativos
Authors: Di Bella Daniela V. , Irwin Terry
Published: August 2023

El Proyecto de Investigación 4.5 Investiga acerca del diseño, la arquitectura, el urbanismo y el arte como fundamentales en toda actividad humana, en relación con que representan el nexo de valores, actitudes, necesidades y acciones de modificación.
Investigación en Diseño Memoria 2015-2020
Authors: Echevarría Oscar
Published: August 2023

El Proyecto de Investigación 16.8 presenta el Volumen 1 del Programa de Investigación en Diseño que incluye la recopilación documental de las Líneas 1 a 9 y sus 27 Proyectos respectivos finalizados al año 2020, e inaugura la serie Memorias y Evaluación de Investigación dentro de la Línea N°16 Documentos de Investigación en Diseño en Palermo. Se constituye en una Serie Documental que se integra a la Línea N°16, la que pasa a estar conformada por tres Series Documentales profundamente interrelacionadas entre sí (a) Memorias y Evaluación de Investigación, (b) Catálogos de Tesis de Posgrado y (c) Catálogos del Programa Estímulo a la Investigación.
La identidad visual en los servicios del sector privado en Cuba
Authors: Escobar Mateo Alejandro
Published: August 2023

El presente artículo aborda la temática de la identidad visual en los nuevos servicios del sector no estatal o privado.
Efecto de la aplicación de biochar en la actividad microbiana en suelos: Revisión
Authors: Melo Lozano Harold Andrés , Afanasjeva Natalia
Published: August 2023

El biochar (BC) se presenta como una enmienda para suelos a partir del residuo de pirólisis de biomasa, que promueve el incremento de las comunidades bacterianas y micorrícicas benéficas y de nutrientes elementales para la fertilidad vegetal; por sus características, aporta carbono recalcitrante, genera cambios fisicoquímicos positivos como el incremento del pH, el aumento de la retención de agua en suelo y en la capacidad de intercambio catiónico. La mayoría de los artículos sobre BC se enfocan en evaluar los resultados de variables fisicoquímicas del suelo, sin embargo, son escasos los estudios que expliquen cómo y porqué el BC incrementa las comunidades microbianas benéficas para el crecimiento vegetal, razón por la cual es necesario analizarlos selectivamente para definir las causas y los efectos de la interacción entre el BC y los microorganismos del suelo. Esta revisión examina publicaciones de los últimos 12 años de investigación sobre el BC en diferentes bases de datos (ScienceDirect, Scopus, Springerlink, SciELO, Google Scholar), enfocándose en los años (2020-2022), con el fin de elucidar los mecanismos subyacentes que permiten la interacción entre BC-comunidades microbianas del suelo y sus beneficios como enmienda agrícola. La hipótesis aceptada es que la alta porosidad del BC que puede servir como “microhábitat” permite las condiciones ideales de espacio, temperatura, humedad y alimento para alterar los niveles de rizobacterias y hongos micorrícicos involucrados en la solubilización de nutrientes como N, P y K aumentando los niveles exo-enzimáticos de deshidrogenasa, β-glucosidasa, ureasa entre otras, mejorando la fertilidad del suelo y el crecimiento de plantas.
The Shields of the Empire: Eastern Roman Military Elites during the Reigns of the Emperors Theodosius II, Marcian and Leo I.: No. XLVII
Authors: Pigoński Łukasz
Published: August 2023

Przedmiotem rozważań tej monografii są wschodniorzymskie elity wojskowe i ich wpływ na funkcjonowanie Imperium za czasów panowania Teodozjusza II, Marcjana i Leona I (408–471). Autor bada proces odtworzenia się elit wojskowych po buncie Gainasa, wzrostu ich znaczenia dzięki wojnom z początku panowania Teodozjusza II, oraz rosnącego niezadowolenia wodzów z polityki zagranicznej cesarza pod koniec jego rządów. To właśnie ta opozycja była czynnikiem zjednującym tak różne postacie jak Flawiusz Zenon, Aspar czy Apolloniusz, w wyniku czego ostatecznie doszło do wykształcenia się jednolitej grupy, jaką były elity wojskowe. Następujące po rządach Teodozjusza II panowanie cesarza Marcjana było pod wieloma względami urzeczywistnieniem ich politycznych ambicji. W ciągu tych wydarzeń, Aspar, dzięki temu, że przeżył pozostałych znaczących dowódców stał się najpotężniejszą osobą w Imperium. W wyniku tego mógł samodzielnie wybrać następcę tronu - Leona. Autor bada, w jaki sposób władza Aspara i jego rodziny przejawiała się podczas panowania cesarza, a także jak doszło do kłótni się pomiędzy cesarzem i wodzem, a następnie eskalacji ich konfliktu. Praca krytycznie podchodzi do wielu założeń przyjętych w nauce, zwłaszcza powszechnego w starszej literaturze wyjaśniania konfliktów między cesarzami a wodzami jako motywowanych czynnikami etnicznymi, a także przewartościowuje współczesne koncepcje, które próbują wyjaśnić dynamikę opisywanych wydarzeń w kontekście sporów dynastycznych lub religijnych. Autor twierdzi, że motywacje elit wojskowych należy przede wszystkim rozumieć w kategoriach politycznych, zaś wodzom zależało na tym by skutecznie chronić Imperium przed zagrożeniami. Konflikty między wodzami a cesarzami wynikały głównie z różnicy zdań co do tego, jak ten cel osiągnąć. Przedstawiciele elit wojskowych byli, co do zasady, przeciwni angażowaniu ograniczonych możliwości militarnych w ryzykowne ekspedycje wojskowe, wydaje się też, że nie poczuwali się w obowiązku do pomocy Cesarstwu Zachodniorzymskiemu, czując się odpowiedzialnymi wyłącznie za bezpieczeństwo ich własnej ojczyzny - części cesarstwa podległej władzy Konstantynopola.
Ortaokul ve Liselerde Görev Yapan Müzik Öğretmenlerinin Müzik Derslerinde Kullandıkları Çalgıların Tespiti
Authors: TERZİOĞLU Ahmet Mutlu
Published: August 2023

Bu araştırma, ortaokul ve lise kademelerinde görev yapan müzik öğretmenlerinin sınıfta kullandıkları çalgıları çeşitli değişkenler bağlamında tespit etmek amacıyla yapılmıştır. Araştırma grubunu ücretli, sözleşmeli ve kadrolu pozisyonlarında çalışan 80 erkek ve 74 kadın olmak üzere toplamda 154 müzik öğretmeni oluşturmaktadır. Araştırmanın verileri anket (survey) yöntemiyle toplanmıştır. Anketlerin amacı toplanan bilgilerle kalıplar oluşturulup, seçilen örnekleme aynı sorular sorulup, istenilen karşılaştırmaları yapmaktır (Çepni, 2001). Veriler nicel araştırma yöntemlerinden ilişkisel tarama yöntemi kullanılarak analiz edilmiştir. İki ya da daha çok sayıdaki değişken arasında birlikte değişim varlığını ya / ya da derecesini belirlemeyi amaçlayan araştırma modellerine de “ilişkisel tarama modelleri” denir (Karasar, 2013). Değişkenler arasındaki ilişkiyi gözlemleyebilmek için ki-kare testi yapılmıştır. Ki-kare testi, gözlenen frekanslar (G) ile beklenen frekanslar (B) arasındaki farkın istatistik olarak anlamlı olup olmadığı temeline dayanır (Güngör ve Bulut, 2008). Ayrıntılı bir biçimde ortaya koymak için ise cross tabulation analizi yapılmıştır. Çapraz tablolama (cross tabulation) iki veya daha fazla değişkene ait cevapların aynı tablo üzerinde gösterilmesi işlemi olup istatistiksel analizlerde oldukça önemli bir yere sahip olan ki-kare analiz tekniği için de temel oluşturmaktadır (Altunışık R, ve diğerleri, 2010). Araştırmaya katılan öğretmenlerin çoğunluğunu kadrolu, eğitim fakültesi mezunu, ortaokul birimlerinde görev yapan ve 11-20 yıl arası kıdemli müzik öğretmenleri oluşturmaktadır. Katılımcıların çoğunluğu (n=30) lisansta bağlama çalgısı eğitimi almış, ama derslerde yoğunlukla piyano çalgısını kullanmaktadır (n=28). Kadın öğretmenler derslerde en fazla gitar çalgısını tercih ederken (n=12), erkek öğretmenler ise bağlama ve gitar çalgılarını (n=20) daha fazla tercih etmektedir. Ortaokullarda görev yapan öğretmenler piyano çalgısını daha fazla tercih ederken (n=31), liselerde görev yapan öğretmenler ise bağlama çalgısını daha sık tercih etmektedir (n=16). Katılımcıların çoğu lisansta eğitimini aldıkları çalgıları öğrenci çalgısı olarak önermemiş ama öğretmen çalgısı olarak önermiştir. Araştırmadan elde edilen sonuçlar doğrultusunda ise öğretmenlerin mesleki tutum ve davranışlarını yönlendirici, geliştirici ve bakış açılarını değiştireceği düşünülen birtakım önerilerde bulunulmuştur.
Anxiety and Depression Symptoms During the COVID-19 Pandemic: A Cluster Analysis of Individuals Living in Portugal
Authors: Aguiar Ana , Bezerra Ana , Gaio Rita , Pinto Marta , Duarte Raquel
Published: August 2023

Introduction: The COVID-19 pandemic is an illustration of how a physical illness can damage people’s minds. In this regard, the goal of this study was to see how different sociodemographic and behavioral factors were linked to anxiety and depression symptoms in a group of individuals living in Portugal. Methods: Between November 2020 and February 2021, a cross-sectional, snowball online study was conducted. The study’s target population was adults over the age of 18, residents of the country. For the statistical analysis, the clustering technique – K-means algorithm was applied. The chi-squared test was used to determine the relationships between clusters and sociodemographic and behavioral characteristics. Statistical analyses were conducted in R language, with a significance level of 0.05. A total of 453 participants were included. Results: The majority were female (69.8%), under the age of 40 (60.8%), with a higher education degree (75.3%), and not married (54.4%). Furthermore, the majority were from the country’s north region (66%). Cluster 1 (n = 194) was characterized by low or nonexistent levels of anxiety and depression symptoms, which means normal; cluster 2 by severe symptoms (n = 82), meaning case; and cluster 3 by mild symptoms (n = 177), which means borderline. Younger participants (p-value 0.024), female (p-value 0.041), with drinking habits (p-value 0.002), food insecurity (p-value < 0.001), food affordability exacerbation (p-value < 0.001), comorbidity (p-value < 0.001), use of anxiolytics (p-value < 0.001), insufficient household income (p-value 0.017) and income change (p-value < 0.001) were significantly associated with the anxiety-depression clusters. From the three clusters, cluster 2 was mainly represented by younger participants, with more persons stating that their household income was insufficient and that their income has changed as a result of COVID-19 and that they had the highest probability of food insecurity. Conclusion: The impacts of a crisis on mental health extend longer than the event itself. We were able to observe that younger women with insufficient household income who suffered a change in income due to COVID-19 and were classified as food insecure presented higher levels of anxiety and depression symptoms. These results highlight the presence of a social gradient where we saw that people who were less advantaged in terms of socioeconomic position presented worse mental health outcomes, stressing, in this sense, the need to bring the best public health responses for these specific groups of the population.
BECOMING A GREEN UNIVERSITY IN SUPPORT OF THE GREEN ECONOMY: A CASE STUDY AT A MARITIME UNIVERSITY
Authors: Ozdemir Pınar
Published: August 2023

The damage caused to nature by human beings caught up in the wheels of the industry is increasing day by day. As a result, environmentally conscious people have started to take various measures to stop and possibly even reverse the damage. One of the first stops for these people who set out to turn the environmentally insensitive economy into a green one is schools, because they have an important role in raising public awareness. It is the duty of schools to educate and train their students not only to fight the harmful effects of the industry on nature but also to get them to adopt a green economy, which introduces environmentally friendly practices. In this study, firstly the environmental sensitivity and awareness levels of students studying at a maritime university were given with a special emphasis on maritime, and then an environmentally sensitive maritime university was examined from different perspectives. The study concluded that a green university should not only instil environmental awareness in its students but also lead environmentally conscious practices, internalize environmental protection in all aspects, and act with this awareness in all its practices. Further studies on this subject may investigate the obstacles which universities aiming to become green may face and how these obstacles can be overcome.
Dense fog simulation in southern Brazil using the WRF model with high spatial resolution
Authors:   Department of Meteorology, Geosciences Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, 21941-916, Brazil, Rodrigues Cardoso Judith , Marton Edilson ,   Department of Meteorology, Geosciences Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, 21941-916, Brazil, Rodrigues Pinheiro Flávia ,   Brazilian Navy Hydrographic Center, Niterói, RJ, 24048-900, Brazil, Cossich William ,   National Electric System Operator, Rio de Janeiro, RJ, 20211-160, Brazil, Oliveira Moraes Nilton ,   Laboratory for Computational Methods in Engineering, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21941-909, Brazil
Published: August 2023

Fog is an atmospheric phenomenon that reduces horizontal visibility to 1000 m or less. These phenomena affect different human activities, mainly those associated with air, maritime, and road transport. Rio Grande city, located in southern Brazil, has one of the main Brazilian ports, and fog occurrences at this location cause several inconveniences, such as the interruption of port activities and increases in operating costs. Thus, a better understanding of fog formation and dissipation, and the consequent improvement in its forecasts, can bring significant help to the port activities in that region. Therefore, this work seeks to evaluate the WRF model’s ability to simulate fog events in Rio Grande city. Four study cases of dense fogs were performed for this goal, as well as a sensitivity test to select the best vertical resolution configuration of the model. Meteorological data from the Rio Grande pilotage station and the Brazilian Coastal Monitoring System buoys were analyzed. Satellite images and synoptic charts were also analyzed for the study cases. The numerical simulations were performed using the WRF model with three nested domains, where 1 km was the highest horizontal resolution. The Fog Stability Index (FSI) and two estimates of horizontal visibility were evaluated. Simulations show promising results, highlighting the ability of the model to identify the fog occurrence in the area of interest and represent aspects of its dissipation process. Furthermore, it is noteworthy that the FSI and the evaluated visibility estimates were sensitive to the occurrence of the events.
Net Energy Gain from a Berry Geometrical Phase – Low-Energy Perturbations of the Strong Interaction and the QCD Mass Gap
Authors: Gibbons Mark
Published: August 2023

Berry curvature is deemed responsible for generating work in a strongly metastable system containing dynamically responsive clathrate hydrate structures. Hyperbolic curvature produces non-extensive volume changes and is attributed to gluon emission and reabsorption in a U(2) electroweak symmetry group synchronized across the condensed matter system, the embedding vacuum manifold and associated quantum interactions. The property of asymptotic freedom is evident across these three domains. Pressure perturbations of the low-energy system initiate ‘rolling’ critical responses that conserve energy and momentum across the synchronized U(2) group and also reveal an emergent gauge field. The corresponding emergence of a Ginzberg-Landau superconducting phase transition is consistent with gauge-invariant coupling of this scalar field to the Yang-Mills action of QCD. The discovery of an energy gap in the gradient energy term of the system Lagrangian is associated with a critical correlation length and is consistent with a complex energy band gap in the Berry phase. Coupled with the emergence and absorption of the Higgs-like scalar field, a mechanism for describing the QCD mass gap arises.
Kimura’s Theory of Non-adaptive Radiation and Peto’s Paradox: A Missing Link?
Authors: Herrick John
Published: August 2023

A strong correlation between karyotype diversity and species richness in mammals was first reported over forty years ago: in mammalian phylogenetic clades, standard deviation of karyotype diversity (KD) closely corresponds to the standard deviation of species richness (SR). These initial studies, however, did not control for phylogenetic signal, raising the possibility that the correlation was due to phylogenetic relatedness among species in a clade. Accordingly, karyotype diversity trivially reflects species diversity simply as a passive consequence of adaptive radiations. A more recent study in mammals has controlled for phylogenetic signal and established the correlation as phylogenetically independent, suggesting that species diversity cannot, in itself, explain the observed corresponding karyotype diversity. The correlation is therefore remarkable because the mechanisms contributing to karyotype diversity are evolutionarily independent of the mechanisms contributing to species diversity. Recently, it was shown in salamanders that the two processes generating genetic diversity and species diversity are indeed independent and operate in parallel, suggesting a potential non-adaptive and non-causal relationship between the two fundamental variables involved in adaptive radiations. The following will examine the relationship between KD and SR in the context of Motoo Kimura’s theory of non-adaptive radiation.
Inheritance of the Resistance to Acanthoscelides obtectus (Say.) in a Heterogeneous Inbred Families Population of Bean (Phaseolus vulgaris L.)
Authors: Ayala-Ruiz Adriana Yuzaleth , Castellanos-Pérez Gloria , Jiménez-Galindo José Cruz , Ramírez-Cabral Nadiezhda , Ramírez-Valle Orlando , Figueroa-González Juan José , Malvar Rosa A.
Published: August 2023

The bean weevil (Acanthoscelides obtectus (Say.)) is one of the main pests of stored beans in the world. Heterogeneous Inbreed Families (HIF) Population of Near Isogenic Lines (NILs) could be an exceptional strategy to study the inheritance of the resistance against A. obtectus. We developed a HIF population of NILs of R-bufa-80-12 (Phaseolus vulgaris) to study the inheritance related to bean weevil resistance and to search NILs with high resistance to the pest within the HIF population. The objective of this research was to study the inheritance in a HIF population and to identify the best lines to provide weevil resistance in bean breeding for commercial genotypes that could reduce pesticide applications. To achieve this objective, we developed a set of 148 NILs which were near-homozygous in the genome, except in the region under study. The HIF were evaluated in two environments under natural infestation with A. obtectus in free choice bioassays in a warehouse highly infested. The population showed wide variability for the traits studied, from 17.2 to 29.2 g for 100 seed weight, 0.0-0.8 for consumption in grams, 2.0-30.0 for consumption in percent and 1.2-9.6 for preference (number of adults in the bottle to the end of the experiments. The heritabilities for resistance traits were from very low to low 0.0 to 0.19. The heritability for 100 seed weight was the highest, with a value of 0.90. All traits studied in this research have a normal distribution, so they are considered to be quantitatively inherited. However, a great variability was found for the traits studied, which allows selecting lines with a high level of resistance within the R-bufa-80-12 HIF population. All traits studied in present research are of quantitative inheritance. The best lines of the HIF population for resistance to A. obtectus were the Line-45, Line-129, Line-124, Line-108 and Line-47.
Small Heterodimer Partner Modulates Macrophage Differentiation during Innate Immune Response through the Regulation of Pparg, MAPK and NF-kB Pathways
Authors: Ahamed Forkan , Eppler Natalie , Johns Elizabeth , He Lily , Zhang Yuxia
Published: August 2023

Hepatic macrophages act as the liver’s first line of defense against injury. Their differentiation into pro-inflammatory or anti-inflammatory subpopulations is a critical event that maintains a delicate balance between liver injury and repair. In our investigation, we explored the influence of the small heterodimer partner (SHP), a nuclear receptor primarily associated with metabolism, on macrophage differentiation during the innate immune response. During macrophage differentiation, we observed significant alterations in Shp mRNA expression. Deletion of SHP promoted M1 differentiation while interfering with M2 polarization. Conversely, overexpression of SHP resulted in increased expression of peroxisome proliferator activated receptor gamma (Pparg), a master regulator of anti-inflammatory macrophage differentiation, thereby inhibiting M1 differentiation. Upon lipopolysaccharide (LPS) injection, there was a notable increase in the pro-inflammatory M1-like macrophages, accompanied by exacerbated infiltration of monocyte-derived macrophages (MDMs) into the livers of Shp myeloid cell specific knockout (Shp-MKO). Concurrently, we observed significant induction of tumor necrosis factor alpha (Tnfa) and chemokine (C-C motif) ligand 2 (Ccl2) expression in LPS-treated Shp-MKO livers. Additionally, the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kB) pathways were activated in LPS-treated Shp-MKO livers. Consistently, both pathways were hindered in SHP overexpression macrophages. Finally, we demonstrated that SHP interacts with p65, thereby influencing macrophage immune repones. In summary, our study uncovered a previously unrecognized role of SHP in promoting anti-inflammatory macrophage differentiation during the innate immune response. This was achieved by SHP acting as a regulator for the Pparg, MAPK and NF-kB pathways.
Evaluation of an Automatic Meteorological Drone Based on a 6-Months Measurement Campaign
Authors: Hervo Maxime , Romanens Gonzague , Martucci Giovanni , Weusthoff Tanja , Haefele Alexander
Published: August 2023

From December 2021 to May 2022, MeteoSwiss and Meteomatics conducted a proof of concept to demonstrate the capability of Meteodrones to provide data of sufficient quality and reliability on a routine operational basis. Over 6 months, Meteodrones MM-670 were operated automati-cally 8 times per night at Payerne, Switzerland. 864 meteorological profiles were measured and compared to co-located standard measurements including radiosoundings and remote-sensing instruments. To our knowledge, it is the first time that Meteodrone’s atmospheric profiles are evaluated in such an extensive campaign. The paper highlights two case studies that showcase the performance and challenges of measur-ing temperature, humidity, and wind with a Meteodrone. It also focuses on the overall quality of the drone measurements. Throughout the campaign, the availability of Meteodrone measure-ments was 75.7%, with 82.2% of the flights reaching the nominal altitude of 2000m above sea level. To assess the quality of the Meteodrone measurements, the radiosondes were used as a refer-ence, comparing them to the WMO (World Meteorological Organization) requirements [1]. The temperature measurements by the Meteodrone met the "breakthrough" target, while the humid-ity and wind profiles met the "threshold" target for high-resolution numerical weather predic-tion. The temperature measurement quality was comparable to that of a microwave radiometer, and the humidity quality was similar to that obtained from a Raman Lidar. However, the wind measurements by a Doppler Lidar were more accurate than the estimation provided by the Me-teodrone. During this campaign, the data quality could be improved and at the end of the campaign, Me-teodrone quality reached the “goal” target for temperature and the “breakthrough” target for humidity. This campaign marks a significant step towards the operational use of automatic drones for me-teorological applications.
Evolving a Model for Cochlear Implant Outcome
Authors: Hoppe Ulrich , Hast Anne , Hornung Joachim , Hocke Thomas
Published: August 2023

Background: Cochlear implantation is an efficient treatment for postlingually deafened adults who do not benefit sufficiently from acoustic amplification. Implantation is indicated when it can be foreseen that speech recognition with a cochlear implant (CI) is superior to that with a hearing aid. Especially for subjects with residual speech recognition it is desirable to predict CI outcome on the basis of preoperative audiological tests. Purpose: The purpose of the study was to extend and to refine a previously developed model for CI outcome prediction for subjects with preoperative word recognition to include subjects with no residual hearing by incorporat-ing additional results of routine examinations. Results: By introducing the duration of unaided hearing loss (DuHL) the median absolute error (MAE) of the prediction was reduced. While for subjects with preoperative speech recognition the model modification did not change the MAE, for subjects with no residual speech recognition before surgery, the MAE decreased from 23.7% with the previous model to 17.2% with the extended model. Conclusions: Prediction of word recognition with CI is possible within clinically relevant limits. Outcome prediction is particu-larly important for preoperative counselling and in CI aftercare, to support systematic monitor-ing of CI fitting.
An Updated Review of Developing Small Molecule Kinase Inhibitors Using Computer-Aided Drug Design Approaches
Authors: Li Linwei , Liu Songtao , Wang Bi , Liu Fei , Xu Shu , Li Pirui , Chen Yu
Published: August 2023

Small molecule kinase inhibitors (SMKIs) are one of the heightened concerns in the field of drug research and development. There are seventy-nine (up to July 2023) small molecule kinase inhibitors have been approved by FDA and hundreds kinase inhibitors candidates in clinical trials, which shed light on the treatment of some major diseases. As an important strategy of drug design, computer-aided drug design (CADD) plays an indispensable role in the discovery of SMKIs. CADD methods, such as docking, molecular dynamic, pharmacophore have been applied to the design and optimization of small molecule kinase inhibitors. In the review, we provide an overview of recent advances in CADD and SMKIs; and the application of CADD for discovery of SMKIs.
Copper and Zinc MOFs With Bipyrazole Linkers Display Strong Antibacterial Activity Against Both Gram+ and Gram- Bacterial Strains
Authors: Xhafa Sonila , Olivieri Laura , Di Nicola Corrado , Pettinari Riccardo , Pettinari Claudio , Tombesi Alessia , Marchetti Fabio
Published: August 2023

Here we report a new synthetic protocol based on Microwave- Assisted Synthesis (MAS) for the preparation in higher yields of zinc and copper MOFs based on different bis(pyrazolyl)-tagged ligands ([M(BPZ)]n where M = Zn(II), Cu(II), H2BPZ = 4,4′-bipyrazole, [M(BPZ-NH2)]n where M = Zn(II), Cu(II); H2BPZ-NH2 = 3-amino-4,4’-bipyrazole, and [Mx(Me4BPZPh)] where M = Zn(II), x = 1; Cu(II), x = 2; H2Me4BPZPh = bis-4′-(3′,5′-dimethyl)- pyrazolylbenzene) and a detailed study of their antibacterial activity, tested against Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria, as representative agents of infections. The results show that all MOFs exert a broad-spectrum activity and strong efficiency in bacterial growth inhibition, with a mechanism of action based on surface contact of MOFs particles with bacterial cells through the so-called “chelation effect” and reactive oxygen species (ROS) generation, without a significant release of Zn(II) and Cu(II) ions. In addition, morphological changes were elucidated by using scanning electron microscope (SEM) and bacterial cell damage was further confirmed by confocal laser scanning microscopy (CLSM) test.
Multilayer Epitaxial Heterostructures With Multi-Component III–V:Fe Magnetic Semiconductors
Authors: Kudrin Alexey V. , Lesnikov Valeri P. , Kriukov Ruslan N. , Danilov Yuri A. , Dorokhin Mikhail V. , Yakovleva Anastasia A. , Tabachkova Nataliya Yu. , Sobolev Nikolai A.
Published: August 2023

Three-layer structures based on various multi-component films of III–V semiconductors heavily doped with Fe were grown by pulsed laser sputtering of InSb, GaSb, InAs, GaAs and Fe solid targets. The structures comprising InAsSb:Fe, InGaSb:Fe and InSb:Fe layers with Fe concentrations up to 24 at. % separated by GaAs spacers were deposited on (001) i-GaAs substrates at 200ºC. Transmission electron microscopy showed that the structures have a rather high crystalline quality and do not contain secondary-phase inclusions. X-ray photoelectron spectroscopy investigations revealed significant diffusion of Ga atoms from the GaAs regions into the InAsSb:Fe layers, which has led to the formation of an InGaAsSb:Fe compound with a Ga content up to 20 at. %. It has been found that the ferromagnetic properties of the InAsSb:Fe magnetic semiconductor improve with increasing Sb:As ratio. It has been concluded that the indirect ferromagnetic exchange interaction between Fe atoms occurs predominantly via Sb atoms.
Artificial Intelligence Prediction of Gestational Age of Fetal in Brain Magnetic Resonance Imaging versus ultrasound Using three different Biometric Measurements
Authors: Vahedifard Farzan , Liu Xuchu , Marathu Kranthi K. , Kocak Mehmet , Ai H. Asher , Supanich Mark P. , Adler Seth , Ansari Shehbaz M. , Akyuz Melih , Adepoju Jubril O. , Byrd Sharon
Published: August 2023

Abstract: Accurately predicting a fetus's gestational age (GA) is of utmost importance in prenatal care. This study aimed to develop an artificial intelligence (AI) model that can automatically predict GA using biometric measurements derived from fetal brain mag-netic resonance imaging (MRI). Additionally, we aimed to assess the significance of con-sidering different references when interpreting GA predictions. To achieve this, we obtained measurements such as Biparietal Diameter (BPD), Fron-to-occipital Diameter (FOD), and Head Circumference (HC) from a dataset comprising 52 normal fetal MRI cases with T2 Haste sequences from Rush University. Both manual and AI-based methods were utilized to acquire these measurements. We also employed three reference papers (Garel, Freq, and Bio) for comparison purposes. The results demonstrated a strong correlation between manual and AI measure-ments, indicating consistency between the two methods. The AI-based measurement of HC exhibited a higher correlation with actual values compared to BPD, FOD, and correct-ed BPD (BPDC). When comparing these measurements with GA in the Picture Archiving and Communication System (PACS), the differences varied depending on the reference used. Specifically, the differences ranged from 0.47 to 2.17 weeks for BPD, 0.46 to 2.26 weeks for FOD, and 0.75 to 1.74 weeks for HC. Furthermore, the Pearson correlation coeffi-cient analysis revealed that all correlation coefficients between PACS records and GA pre-dictions using different references were greater than 0.97. In conclusion, the AI model based on fetal brain MRI accurately predicts GA by uti-lizing BPD, FOD, and HC measurements. The AI approach, which involves combining line segments to calculate fetal head circumference, offers improved accuracy and con-venience compared to manual estimation. This study underscores the potential of AI models in accurately estimating gestational age and highlights their utility in prenatal care. By integrating AI as a valuable tool in prenatal care, we can enhance the accuracy, ef-ficiency, and decision-making involved in assessing fetal development and monitoring pregnancies using MRI measurements.
What Are the Causes of Death Among Patients Admitted to a Contemporary Tertiary Level Cardiology Department? An Analysis of 10 Years of Morbidity & Mortality Meetings
Authors: Kwok Chun Shing , Tafuro Jacopo , Wong Chun Wai , Bennett Sadie , Zachariah Donah , Barker Diane , Morley-Davies Adrian , Satchithananda Duwarakan , Gunning Mark , Borovac Josip Andelo
Published: August 2023

Despite the efforts to deliver the best evidence-based care, in-hospital death is an inevitable event among some patients hospitalized in cardiology departments. We retrospectively evaluated mortality events from inpatient admissions to Cardiology Department between 2010-2019. Data were collected from morbidity & mortality meeting presentations which evaluated comorbidities, medical history, treatments, and causes of death for the overall cohort and according to age group and sex. There were 1,182 registered deaths. The most common causes of death among patients were acute myocardial infarction (AMI) (53.0%), heart failure (HF, 11.7%), cardiac arrest (CA, 6.6%), HF with complication/defined cardiomyopathy (6.3%) and sepsis (4.4%). We observed a decline in deaths from AMI from 61.9% in 2010 to 46.7% in 2019 while there was an apparent increase in deaths from HF (11.1% in 2010 to 25.9% in 2019). Compared to patients ≥65 years, younger patients were more likely to have died from CA (15.7% vs. 4.3%, p<0.001) and other cardiac reasons (3.0% vs. 0.4%, p<0.001). The majority of deaths were due to AMI, HF, and CA. We observed a significant decline in the proportion of deaths due to AMI in recent years with an increase in deaths due to HF.
Structural and Luminescence Properties of Eu-Doped PMO Films with Ethylene Bridge and Methyl Terminal Groups
Authors: Rasadujjaman Md , Zhang Jinming , Vishnevskiy Alexey S. , Zhang Jing , Baklanov Mikhail R.
Published: August 2023

Nanoporous films of Eu-doped organosilicate glass (OSG) have been synthesized using sol-gel technology and spin-coating, employing evaporation-induced self-assembly (EISA), on silicon wafers. The Eu doping is achieved by dissolution of Eu(NO3)3·6H2O in the precursor solution. The deposited films are characterized by using Fourier transform infrared (FTIR) spectroscopy, ellipsometric porosimetry (EP), X-ray photoelectron spectroscopy (XPS) and photoluminescence spectroscopy. It is observed that Eu doping makes the films more hydrophilic and reduces the pore size and open porosity. The reduction Eu3+ → Eu2+ occurs in the pores of OSG films, which is confirmed by depth profiling XPS. However, Eu3+ still presents on the film’s top surface. Presence of Eu3+ and Eu2+ gives characteristic luminescence emission in the range of 600‒630 nm (Eu3+) and 290‒400 nm (Eu2+). The Eu2+/Eu3+ concentrations ratio depends on CH3 groups concentration in the films. Moreover, concentration of Eu2+ ions in the pores can be reduced by exposure in inductively coupled (ICP) oxygen plasma. The observed shift of the luminescence spectra towards the UV region, in comparison to previously reported Eu-doped organosilicate films, can be attributed to the energy transfer occurring between the host material and Eu2+ ions.
Holographic Recording of Unslanted Volume Transmission Gratings in Acrylamide/Propargyl Acrylate Hydrogel Layers: Towards Nucleic Acids Biosensing
Authors: Zezza Paola , Lucío María Isabel , Naydenova Izabela , Bañuls María-José , Maquieira Ángel
Published: August 2023

The role of volume hydrogel holographic gratings as optical transducers in sensor devices for point-of-care applications is increasing due to their ability to be functionalized for achieving enhanced selectivity. The first step in the development of these transducers is the optimization of the holographic recording process. The optimization aims at achieving gratings with reproducible diffraction efficiency, which remains stable after reiterative washings, typically required when working with analytes of biological nature or several step tests. The recording process of volume phase transmission gratings within acrylamide/propargyl acrylate hydrogel layers reported in this work was successfully performed and the obtained diffraction gratings were optically characterized. Unslanted volume transmission gratings were recorded in the hydrogel layers and using the optimized conditions, diffraction efficiencies of up to 80% were achieved. Additionally, the recorded gratings demonstrated to be stable in water after multiple washings. The hydrogels, after functionalization with oligonucleotide probes yields specific hybridization response, recognizing the complementary strand as demonstrated by fluorescence. Analyte-sensitive hydrogel layers with holographic structures are a promising candidate for the next generation of in vitro diagnostic tests.
The Urinary Metabolomic Fingerprint in Extremely Preterm Infants on Total Parenteral Nutrition vs Enteral Feeds
Authors: Guardado Miguel , Steurer Martina , Chapin Cheryl , Hernandez Ryan D. , Ballard Philip L. , Torgerson Dara
Published: August 2023

Total Parenteral Nutrition (TPN), which uses intravenous administration of nutrients, minerals and vitamins, is essential in sustaining premature infants until they transition to enteral feeds. There is limited information on metabolomic differences between infants on TPN and enteral feeds. We performed untargeted global metabolomics on urine samples collected between 23-30 days of life from 314 infants born <29 weeks gestational age from the TOLSURF and PROP cohorts. Principal component analysis across all metabolites showed a separation of infants solely on TPN as compared to infants who had transitioned to enteral feeds, indicating global metabolomic differences between infants based on feeding status. Among 913 metabolites that passed quality control filters, 609 varied in abundance between infants on TPN vs enteral feeds at p<0.05. Of these, 88% were in the direction of higher abundance in the urine of infants on enteral feeds. In a subset of infants with longitudinal analysis, both concurrent and delayed changes in metabolite levels were observed with initiation of enteral feeds. Infants on enteral feeds had higher concentrations of essential amino acids, lipids, and vitamins, which are necessary for growth and development, suggesting a nutritional benefit of an enteral feeding regimen.
The Advantages of NGS Molecular Classification in Endometrial Cancer Diagnosis
Authors: Rivera Daniela , Paudice Michele , Accorsi Giulia , Valentino Floriana , Ingaliso Marta , Pianezzi Ada , Roggieri Paola , Trevisan Lucia , Buzzatti Giulia , Mammoliti Serafina , Barra Fabio , Ferrero Simone , Cirmena Gabriella , Gismondi Viviana , Vellone Valerio Gaetano
Published: August 2023

Endometrial cancer (EC) is the most frequent gynaecological malignancy. The ESGO/ESTRO/ESP 2020 guidelines identify prognostic groups based on morpho-molecular characteristics. This study aims to evaluate the clinical applicability of NGS analysis to define an appropriate risk class and application for a better diagnostic and prognostic stratification of ECs. Cases of serous carcinoma (OHEC), high (HGEC) and low (LGEC) grade endometrioid carcinoma diagnosed with the morphological and immunohistochemical (IHC) protocols were considered. After a standardized pre-analytical phase, the tumor DNA was semi-automatically extracted and analyzed by NGS with a panel of 14 genes. A total of 63 cases were considered. NGS analysis was successful in 60 cases; all of these were classified according to the new diagnostic algorithm. The molecular risk classification showed a good correlation with the morphological (k=0.8). The study showed that the protocols of the pre-analytical and analytical phases used are robust and can lead to molecular results that fall within the standards required for use in clinical practice for a more precise diagnostic-therapeutic management of patients. The implementation of the classification is particularly relevant for better prognostic stratification of HGECs. In addition, the identification of a suspicious VUS in POLE questions the classification of truncating variants.
Phenotypic Characterization and Molecular Identification of Potentially Probiotic Lactobacillus sp. Isolated from Fermented Rice
Authors: Jeyagowri Nimalan , Ranadheera Chaminda Senaka , Manap Mohd Yazid , Gamage Ashoka , Merah Othmane , Madhujith Terrence
Published: August 2023

Fermented rice is known as a healthy food due to the presence of lactic acid bacteria as fermentative microorganisms. The study was carried out to discover and characterize the lactic acid bacteria (LAB) from white and red fermented rice (BG varieties). Fermentation was carried out naturally by soaking red, white, raw and cooked rice in water using an earthen pot. Species were confirmed based on 16S r DNA gene sequencing and studied for phenotypic characteristics including morphological, physiological (growth temperature, salt tolerance, milk coagulation) and biochemical characteristics (carbohydrate fermentation pattern) using API 50CH kits. Distinct clusters like cocci (48), diplo cocci (30) and rods (30) shaped bacteria were observed from fermented rice. Five species of lactic acid bacteria including Latilactobacillus curvatus GR Lb1,2 10 and 11 (predominant Bacillus species), Latilactobacillus graminis Lb8, Limosilactobacillus fermentum GRLb17, Weissella confuse GRLb4 and Pediococcus pentosaceus GRLc1 were identified. The base pair length of amplified DNA for the isolates was 1500 Bp. The beneficial physiological and biochemical properties of isolated Lactobacillus species from fermented rice revealed their potential applications in the food industry.
Physico-Chemical and Bacteriological Characterisation of Domestic Wastewater from Adétikopé in Togo
Authors: GBEKLEY Efui Holaly , KOMI Kossi , HOUEDAKOR Koko Zébéto , POLI Sossawè , KPOEZOUM Kossi , ADJALO Djiwonou Koffi , ZINSOU-KLASSOU Kossiwa , TCHACONDO Tchadjobo , AMEYAPOH Yaovi , ADJOUSSI Pèssiezoum
Published: August 2023

Background: Wastewater represents a health risk for populations. For sanitary safety, it is important to know their physico-chemical and microbiological qualities in order to better understand the risks incurred by the population. Objective: The aim of this study is to analyse the microbiological and physico-chemical quality of domestic wastewater in Adétikopé. Methodology: 12 wastewater samples were collected in Adétikopé from December 2022 to February 2023. Physico-chemical parameters were determined in accordance with AFNOR T90-105/ T90-023 and French standard NF T 90101. In microbiology, AFNOR was used as a reference for the detection of germs contaminating wastewater. Results were assessed in relation to European Union Criteria 98/83/EC. Results: The wastewater analyzed had a pH close to neutral, with an average pH of 7.05. The pollutant load generated ranged from 32 mg/l to 201 mg/l for BOD5, from 660 mg/l to 900 mg/l for COD and from 408 mg/l to 2080 mg/l for suspended solids. Concentrations of fecal coliforms and fecal streptococci are very high, far exceeding WHO guidelines for population health safety.