bluuebunny/crossref_metadata_2025 huggingface dataset:
Interactions governing transcriptional activity of nuclear receptors
Authors: Khan Sabab Hasan , Okafor C. Denise
Published: December 2022

The key players in transcriptional regulation are transcription factors (TFs), proteins that bind specific DNA sequences. Several mechanisms exist to turn TFs ‘on’ and ‘off’, including ligand binding which induces conformational changes within TFs, subsequently influencing multiple inter- and intramolecular interactions to drive transcriptional responses. Nuclear receptors are a specific family of ligand-regulated TFs whose activity relies on interactions with DNA, coregulator proteins and other receptors. These multidomain proteins also undergo interdomain interactions on multiple levels, further modulating transcriptional outputs. Cooperation between these distinct interactions is critical for appropriate transcription and remains an intense area of investigation. In this review, we report and summarize recent findings that continue to advance our mechanistic understanding of how interactions between nuclear receptors and diverse partners influence transcription.
Problems and Countermeasures of the Popularization of Cantonese Opera Culture in Colleges
Authors: Gong Hongmin
Published: December 2022

As a treasure of Lingnan art, Cantonese opera audience is mostly among the elderly, and young people today know very little about it, which has a serious impact on the inheritance and development of Cantonese opera art. Although the government and society have been paying more and more attention to Cantonese opera, the results have been limited. As the last stop for students to study, colleges shoulder the important mission of learning professional skills and completing values. Incorporating the art of Cantonese opera into the study and life of colleges, so that students can understand and like Cantonese opera, has a certain positive significance for the development of Cantonese opera.
The Representation of Mosuo People and Mosuo Culture in Chinese Tourism Websites
Authors: Ye Hanwen , Ma Xinjia , Cao Bixuan , Deng Qiuyu , He Jinyu , Yin Ruolan
Published: December 2022

Past research has shown that because tourism itself is a product of a gendered society, its processes are gendered in terms of construction, presentation, and consumption. This study examines how these websites shape the image of the Mosuo people and the Mosuo culture by analyzing texts in Chinese tourism websites. Ten representative Chinese tourism websites were selected for this study, and all relevant texts that could be retrieved were analyzed manually. All samples selected were officially published and represent only the attitudes of the tourism websites. The results of the study show that there are a large number of feminized or sexualized descriptions in the texts about the Mosuo people and the Mosuo culture provided by Chinese tourism websites. The language used on tourism websites is shaped by discourses of patriarchy and sexuality and is intended for heterosexual male tourists.
Research on Financial Risk Assessment Based on Artificial Intelligence
Authors: Zhao Mingkai
Published: December 2022

The effective application of artificial intelligence (AI) models in various fields in the field of financial risk can improve the speed of data processing, deepen the degree of data analysis and reduce the labor cost, thus effectively improving the efficiency of financial risk control. The application of AI in the field of financial risk management puts forward new requirements for the system setup and operation mode of financial supervision. With the rapid growth ofcomputer and network technology, the increase of market transaction frequency, the diversification of data sources and the development and application of big data, it brings new challenges to financial risk management based on massive data. Based on this, this paper analyzes the role of AI in promoting the reform and growth ofthe financial industry, and puts forward some countermeasures for rational use of AI in the field of financial risk management.
Antitrust Law Regulation on “Pick One of Two” Practice of Ecommerce Platforms -Discussion on the Inadequate Application of the Theory of Abusing the Relative Advantage
Authors: Yang Shuai
Published: December 2022

E-commerce has a strong development momentum in recent years, and the oligopoly structure trend of e-commerce platforms has become more and more obvious. At the same time, the “Pick One of Two” behavior of e-commerce platforms has been constantly performed in various fields. Although “Pick One of Two” behavior has existed for many years in China, it has not been effectively regulated so far. The “Pick One of Two” behavior of e-commerce platforms not only destroys the fair competition order between platforms, but also damages the legitimate rights and interests of operators and consumers. In view of this, this paper analyzes the dual nature of e-commerce platform “Pick One of Two” behavior and the inadequacy of the theory of abuse of comparative advantage.
Supervision and Governance of Accounting Information Leakage in Listed Companies-A Case Study of Luckin
Authors: Chen Ruilin
Published: December 2022

After many years of development of securities market, our securities market standard system is increasingly sound. But there are also many problems, such as the disclosure of accounting information of listed companies. It has not formed an accurate and fast system to systematize the disclosure of accounting information in the securities market, which leads to the low efficiency of the securities market. On the other hand, it is of great significance to construct the long-term mechanism of accounting supervision to perfect the national supervision system, strengthen the ability of risk management and control, optimize the quality of accounting information and standardize the market economic order. In a series of important meetings, China proposed that accounting supervision, auditing supervision and statistical supervision should be included as an important part of the national supervision system. Therefore, it can be seen that the construction of longterm mechanism of financial and accounting supervision is the most urgent and top priority to consolidate the foundation of China’s supervision system. In this paper, through the analysis of Luckin coffee incident, put forward the optimization strategy to build a long-term mechanism of accounting supervision in the new era.
Macro Analysis on Apple Stock In order to determine investment value of Apple
Authors: Bai Mingrui
Published: December 2022

The purpose of this article is to address the question of whether Apple is worth investing in by analyzing investment data on Apple’s stock and Apple’s own data. In this article, the author assumes 10,000 shares of Apple Inc stock from January 1, 2020, until August 2, 2022, and uses Yahoo Finance’s historical data to calculate past earnings levels, combined with the author’s macro analysis of Apple’s economic conditions and market conditions to conclude that Apple is well worth investing in over the next 3-5 years.
An empirical study on the relationship between corporate internal control and financial performance of listed companies
Authors: Gu Jingwen
Published: December 2022

The article empirically examines the effect of internal control on corporate financial performance using a panel multiple regression model with a sample of listed A-share companies in Shanghai and Shenzhen from 2013-2021. The results of the study indicate that internal control has a positive impact on the financial performance of enterprises. This study extends the research related to the impact of internal control on corporate financial performance and provides empirical evidence for firms to improve their internal control.
Research on Financing of Small and Micro Enterprises in Shenzhen
Authors: You Desheng
Published: December 2022

With the rapid development of China’s economy, small and micro enterprises have become an important pillar of the national economy. The financing mode and financing channels of small and micro enterprises have been greatly improved, but they are still not comprehensive enough. Credit financing is still the core financing mode of small and micro enterprises. However, most of them are small and micro enterprises. When applying for creditor’s rights financing, it is often difficult to get a satisfactory response. The financing difficulties of small and micro enterprises are the key factors hindering the development of small and micro enterprises. Therefore, it is of great significance for the financial management and development of small and micro enterprises to study the financing problems of small and micro enterprises and analyze the financial problems of small and micro enterprises. This paper summarizes Shenzhen’s finance in recent years through questionnaires. Supporting the experience, practice and achievements of small and micro enterprises in financing, combing the main demands of small and micro enterprises in financing and the problems in financing process of financial support for small and micro enterprises with data, and putting forward relevant suggestions and suggestions.
An Empirical Study on the Efficiency of Financial Support for Economic Development in Henan Province Based on DEA Malmquist Index Method
Authors: Ma Yuqing
Published: December 2022

The report of the 19th National People’s Congress points out that China’s social economy will gradually transition from the pursuit of high-speed operation to the pursuit of high-quality economic operation. The financial industries will strongly support the economic development in all aspects, however, studies show that the efficiency of finance in supporting economic development presents regional differences. This paper adopts the universally applicable DEA-Malmquist method and takes the panel data of Henan Province from 2013 to 2019 as the benchmark to calculate and study the input-output ratio of financial support for economic operation and development in each region of Henan Province, and the results show that the overall efficiency of financial service economy in each urban area of Henan Province has increased in the past seven years. According to the measured results in the first four parts of the most efficiency increase is analyzed, and based on the analysis results in the economic development of Henan province put forward some proposals in the new journey, increase the intensity of financial innovation and development, to carry out in-depth financial inclusion work, and to solve the problem that small and micro enterprises faced in raising funds and the slow pace of raising funds, in order to achieve a reasonable distribution of financial resources between the suppliers of funds and the demanders of funds.
A Review of China’s Public Service Advertising Audience Research Based on Idealized Cognitive Models
Authors: Wu Yuhan
Published: December 2022

With the rapid development of new era and new media, opportunities and challenges of the development of public service advertising coexist. Against the backdrop of the times and the development of media, public service advertising needs to incorporate more subjects, so that the audience can pay more attention to and understand such advertisements. Based on the above social background, how to better publicize the mainstream values of society among the public with the help of public service advertising is what the current government needs to focus on and solve. This research combines the idealized cognitive models to elaborate the social value of public service advertising in the new era, with a view to giving suggestions to the state, government, society and other subjects, and contributing to the vigorous development of public service advertising in China.
Open Thoracoabdominal Aortic Procedures following Endovascular Intervention
Authors: Melloni Andrea , Kahlberg Andrea , Rinaldi Enrico , Bilman Victor , Favia Nicola , Melissano Germano , Chiesa Roberto
Published: December 2022

Open conversion of thoracoabdominal aortic (TAA) disease after failed attempts of endovascular treatment is increasingly required. The main causes are endoleak, endograft failure, infection, disease progression, or persistent false lumen perfusion in dissected aortas. Mortality and morbidity rates are high, higher than after standard TAA open repair. Therefore, this surgery should be performed only in dedicated centers by experienced teams. Specific perioperative organ protection protocols, as well as surgical techniques, are crucial to guarantee acceptable results.
Transsternal and Transpericardial Approach to Descending Thoracic Aorta via Median Sternotomy—An Option for Extensive Aortic Surgery
Authors: Park Kay-Hyun
Published: December 2022

We describe a technique for approaching the distal descending thoracic aorta via median sternotomy and posterior pericardiotomy, which enabled us to perform the extensive aortic repair. While this approach shared the lesser invasiveness of the frozen elephant trunk procedure with less confinement by anatomic features, the advantage was counterbalanced by the high incidence of spinal cord ischemia. This approach can be an option in highly selected patients who require extensive aortic repair but have factors prohibiting other conventional approaches.
Optimal Extent of Repair for Acute Type I Aortic Dissection—Frozen Elephant Trunk? How Long and Why?
Authors: Luc Jessica G. Y. , Preventza Ourania
Published: December 2022

Acute Type A dissection is a life-threatening condition requiring urgent surgical treatment. The operative technique involves repairs of a variety of distal extents of the transverse aortic arch and the downstream aorta. We review the evidence surrounding the extent of repair for acute Type A aortic dissection and describe our approach to this disease.
Frozen Elephant Trunk Procedure and Risk for Distal Stent-Graft-Induced New Entries
Authors: Kreibich Maximilian , Berger Tim , Rylski Bartosz , Siepe Matthias , Czerny Martin
Published: December 2022

The frozen elephant trunk (FET) procedure is known as an effective treatment option for patients with any aortic pathology involving the aortic arch. However, there is growing evidence that many patients often require secondary intended, expected, or unexpected aortic reinterventions during follow-up. In those with underlying aortic dissection pathology, a substantial risk for developing distal stent-graft-induced new entries (dSINEs) has been identified as one cause for secondary aortic reinterventions. dSINE can develop at any time after the FET procedure. Endovascular treatment is generally feasible and safe to close the newly formed entry with low procedural risk. Nevertheless, all patients need continuous follow-up after FET treatment, ideally in a specialized aortic outpatient clinic.
Guillain–Barre Syndrome—A Rare Cause of Quadriparesis after the Bentall Procedure for Type A Aortic Dissection
Authors: Chellasamy Rajeev T. , Kalyanasundaram Aravind , Munuswamy Hemachandren , Sugumaran Ramkumar , Meher Rajesh K.
Published: December 2022

Neurological complications following aortic surgery are most often cerebrovascular accidents due to embolism, or spinal infarcts resulting in hemiparesis or hemiplegia. Guillain–Barre syndrome is a rare cause of quadriparesis. Here, we report a 49–year old male who presented with acute aortic dissection and underwent the Bentall procedure following which he developed quadriparesis, subsequently diagnosed to be a case of Guillain–Barre syndrome. He was successfully treated with intravenous immunoglobulin.
Drug–Drug Interaction between Antiplatelet Therapy and Lipid-Lowering Agents (Statins and PCSK9 Inhibitors)
Authors: Schrör Karsten , Trenk Dietmar , Verheugt Freek W. A.
Published: December 2022

Lipid-lowering agents and antiplatelet drugs are guideline-recommended standard treatment for secondary prevention of acute thrombotic events in patients with increased cardiovascular risk. Aspirin is the most frequently used antiplatelet drug, either alone or in combination with other antiplatelet agents (P2Y12 inhibitors), while statins are first-line treatment of hypercholesterolemia. The well-established mode of action of aspirin is inhibition of platelet-dependent thromboxane formation. In addition, aspirin also improves endothelial oxygen defense via enhanced NO formation and inhibits thrombin formation. Low-dose aspirin exerts in addition anti-inflammatory effects, mainly via inhibition of platelet-initiated activation of white cells.

Statins inhibit platelet function via reduction of circulating low-density lipoprotein-cholesterol (LDL-C) levels and a more direct inhibition of platelet function. This comprises inhibition of thromboxane formation via inhibition of platelet phospholipase A2 and inhibition of (ox)LDL-C-mediated increases in platelet reactivity via the (ox)LDL-C receptor (CD36). Furthermore, statins upregulate endothelial NO-synthase and improve endothelial oxygen defense by inhibition of NADPH-oxidase. PCSK9 antibodies target a serine protease (PCSK9), which promotes the degradation of the LDL-C receptor impacting on LDL-C plasma levels and (ox)LDL-C-receptor-mediated signaling in platelets similar to but more potent than statins.

These functionally synergistic actions are the basis for numerous interactions between antiplatelet and these lipid-lowering drugs, which may, in summary, reduce the incidence of atherothrombotic vascular events.
On the thermal and mechanical properties of Mg0.2Co0.2Ni0.2Cu0.2Zn0.2O across the high-entropy to entropy-stabilized transition
Authors: Rost Christina M. , Schmuckler Daniel L. , Bumgardner Clifton , Bin Hoque Md Shafkat , Diercks David R. , Gaskins John T. , Maria Jon-Paul , Brennecka Geoffrey L. , Li Xiadong , Hopkins Patrick E.
Published: December 2022

As various property studies continue to emerge on high entropy and entropy-stabilized ceramics, we seek a further understanding of the property changes across the phase boundary between “high-entropy” and “entropy-stabilized” phases. The thermal and mechanical properties of bulk ceramic entropy stabilized oxide composition Mg0.2Co0.2Ni0.2Cu0.2Zn0.2O are investigated across this critical transition temperature via the transient plane-source method, temperature-dependent x-ray diffraction, and nano-indentation. The thermal conductivity remains constant within uncertainty across the multi-to-single phase transition at a value of ≈2.5 W/mK, while the linear coefficient of thermal expansion increases nearly 24% from 10.8 to 14.1 × 10−6 K−1. Mechanical softening is also observed across the transition.
Systematic revision of the Japanese freshwater snail
Authors: Sawada Naoto , Fuke Yusuke
Published: December 2022

Semisulcospira is a freshwater snail genus highly divergent in the ancient Lake Biwa, Japan, with a history of ~4 million years. Although the shell morphology, karyotype and molecular phylogeny of the genus have been well studied, the systematic status of several non-monophyletic species remains uncertain. In this study, we have evaluated the taxonomic accounts of the species previously identified as Semisulcospira decipiens, S. habei and relatives. We examined the genetic relationships using genome-wide SNP data and elucidated morphological variation among these using Random Forest classification. Morphological relationships between the name-bearing type of S. decipiens and the newly collected specimens were also evaluated. Morphological characteristics effectively discriminated between the nine genetic clusters, and the correlation among morphology and substrates was elucidated. We revised taxonomic accounts of S. decipiens, S. habei, S. arenicola, S. nakasekoae and S. ourensis and synonymised S. multigranosa, S. habei yamaguchi, S. dilatata under S. decipiens and S. fluvialis under S. nakasekoae. We also described two new species, Semisulcospira elongata sp. nov. and Semisulcospira cryptica sp. nov., and redefined two phylogroups of the lacustrine species as the Semisulcospira niponica-group and the Semisulcospira nakasekoae-group. Traits of the species examined exhibiting intraspecific variation in the different substrates and flow velocity may indicate the morphological and trophic adaptations. The habitat-related variation has certainly caused the taxonomic confusion of the lacustrine species. Lake drainage contributes to increasing the species diversity of the genus, generating ecological isolation between the riverine and lacustrine habitats. ZooBank: urn:lsid:zoobank.org:pub:A83B99F4-8709-4295-86B3-A6C595D65DA0
Exploring the Case: Visitor Information Centres and Millennial Travellers: Remaining Relevant in a Digital Era
Authors: Chui Caleb , Walters Gabby
Published: December 2022

Introduction

Visitor usage of visitor information centres (VICs) has significantly declined during the past decade due to the increasing use and popularity of online information sources. The immediacy and accessibility of online information has resulted in tourists relying primarily on this source of information both prior to and during the travel experience. This is an issue due to the many benefits that VICs provide to business suppliers, local communities and tourists. This case study reveals the perceptions that the digital generation ‘millennials’ have of VICs, in terms of the relevance of such facilities in their digital world. The case follows with recommendations that can help enhance the appeal and relevance of VICs to this important consumer cohort and assist VICs to continue delivering the many benefits such centres offer to both tourists and the tourism community.
Toward a depoliticising civic style. How public-led partnership life socialises the leaders of an association in a French deprived neighbourhood
Authors: Chevallier Thomas
Published: December 2022

This article questions the logics through which neighbourhood social policies such as the ‘Politique de la ville’ in France have effects on the style of action deployed by the associations that participate in their implementation. Through an ethnographic investigation within a particular association, combining observations, interviews, and archive analysis, it shows how the integration of associative leaders into partnership mechanisms led them to professionalise and socialise to a grammar of partnership life, based on a feeling of belonging to a community of partners and on the sharing of certain values. In the case studied, this socialisation is achieved both through rationalised governance technologies and through affective techniques. Thus, this paper shows that it is important not to limit the research’s scope to the study of actions undertaken toward the residents: deprived neighbourhood policies are also composed of a set of measures aimed at governing the intermediaries involved in their implementation.
Novel ternary organic resistive switching memory doped with bipolar materials
Authors: Li Haoyang , Lan Weixia , Wu Xian , Zhu Zhiqiang , Wei Bin
Published: December 2022

Organic resistive switching memory (ORSM) shows great potential for neotype memory devices due to the preponderances of simple architecture, low power consumption, high switching speed and feasibility of large-area fabrication. Herein, solution-processed ternary ORSM devices doped with bipolar materials were achieved with high ON/OFF ratio and outstanding device stability. The resistive switching performance was effectively ameliorated by doping two bipolar materials (DpAn-InAc and DpAn-5BzAc) in different blending concentration into the PVK:OXD-7 donor-accepter system. Compared with the binary system (PVK: 30 wt% OXD-7), the ON/OFF ratios of the ternary devices doped with 6 wt% DpAn-5BzAc were greatly increased from 7.91 × 102 to 4.98 × 104, with the operating voltage (∣V
set–V
reset∣) declined from 4.90 V to 2.25 V, respectively. Additionally, the stability of resistance state and uniformity of operating voltage were also significantly optimized for the ternary devices. For comparison, ternary devices doped with DpAn-InAc have been explored, which also achieved improved resistive switching behavior. A detailed analysis of electrical characteristics and the internal charge transfer properties of ORSM was performed to unveil the performance enhancement in ternary devices. Results indicate that the use of bipolar materials favors the efficient operation of OSRMs with proper energy level alignment and effective charge transfer.
Periodic orbits in the Ott–Antonsen manifold
Authors: Omel’chenko O E
Published: December 2022

In their seminal paper (2008 Chaos
18 037113), Ott and Antonsen showed that large groups of phase oscillators driven by a certain type of common force display low dimensional long-term dynamics, which is described by a small number of ordinary differential equations. This fact was later used as a simplifying reduction technique in many studies of synchronisation phenomena occurring in networks of coupled oscillators and in neural networks. Most of these studies focused mainly on partially synchronised states corresponding to the equilibrium-type dynamics in the so called Ott–Antonsen manifold. Going beyond this paradigm, here we propose a universal approach for the efficient analysis of partially synchronised states with non-equilibrium periodic collective dynamics. Our method is based on the observation that the Poincaré map of the complex Riccati equation, which describes the dynamics in the Ott–Antonsen manifold, coincides with the well-known Möbius transformation. To illustrate the possibilities of our method, we use it to calculate a complete bifurcation diagram of travelling chimera states in a ring network of phase oscillators with asymmetric nonlocal coupling.
A proof-of-concept of cross-luminescent metascintillators: testing results on a BGO:BaF2 metapixel
Authors: Konstantinou G , Latella R , Moliner L , Zhang L , Benlloch J M , Gonzalez A J , Lecoq P
Published: December 2022

Objective: Time-of-flight positron emission tomography (PET) is the next frontier in improving the effective sensitivity. To achieve superior timing for time-of-flight PET, combined with high detection efficiency and cost-effectiveness, we have studied the applicability of BaF2 in metascintillators driven by the timing of cross-luminescence photon production. Approach: Based on previous simulation studies of energy sharing and analytic multi-exponential scintillation pulse, as well as sensitivity characteristics, we have experimentally tested a pixel of 3 × 3 × 15 mm3 based on 300 μm BGO and 300 μm BaF2 layers. To harness the deep ultraviolet cross-luminescent light component, which carries improved timing, we use the FBK VUV SiPM. Metascintillator energy sharing is addressed through a double integration approach. Main results: We reach an energy resolution of 22%, comparable to an 18% resolution of simple BGO pixels using the same readout, through the optimized use of the integrals of the metascintillator pulse in energy sharing calculation. We measure the energy sharing extent of each pulse with a resolution of 25% and demonstrate that experimental and simulation results agree well. Based on the energy sharing, a timewalk correction is applied, exhibiting significant improvements for both the coincidence time resolution (CTR) and the shape of the timing histogram. We reach 242 ps CTR for the entire photopeak, while for a subset of 13% of the most shared events, the CTR value improves to 108 ps, comparable to the 3 × 3 × 5 mm3 LYSO:Ce:Ca reference crystal. Significance: While we are considering different ways to improve further these results, this proof-of-concept demonstrates the applicability of cross-luminescence for metascintillator designs through the application of VUV compatible SiPM coupling, and easily implementable digital algorithms. This is the first test of BaF2-based metascintillators of sufficient stoppng power to be included in a PET scanner, demonstrating the industrial applicability of such cross-luminescent metascintillators.
Experimental Investigation of Water Cooled Solar Photovoltaic Thermal Collector
Authors: Malaiyappan Prakash , Nandha Kumar P , Renuka Devi G
Published: December 2022

With an increasing expected energy demand and current dominance of coal electrification world needs alternative sources which are abundant and ease of availability in nature such as Solar, wind, tidal etc., in which solar PV energy is one of the favorable energy sources. Various strategies are studied in this paper to improve the efficiency of solar PV modules. The efficiency of PV modules increases as the surface temperature of the modules is lowered using various cooling techniques. Experiments on solar PV modules with water circulation have been carried out, and the heat generated has been used for thermal applications. The reference panel was matched to an experimental observation for water circulation. It was observed that the water circulation system is 10.4 %, with a greater performance at 866 W/m2 solar radiation. Water is used as a cooling medium to extract heat from the PV panel. The project’s purpose is to improve the efficiency and power output of hybrid PVT(Photovoltaic Thermal Collectors)while also optimizing the design. The project’s purpose is to improve the efficiency and power output of the hybrid Photovoltaic Thermal Collectors(PVT) collector, as well as the power output of the PV panels. The tests are carried out with and without cooling on a 50W PV panel. The cooling of the PV panel is accomplished through forced and natural convection of water in the duct. The performances of forced and natural circulation are validated with the solar panels output power and efficiency.
Aerodynamic Drag Reduction of Commercial Ground Vehicles Using Numerical Techniques
Authors: Saxena Shreyash , G T Mahesha , G Srinivas
Published: December 2022

Automobiles of today warrants improved aerodynamic behaviour that results in low drag producing vehicles. Such optimally designed vehicles offer advantages such as better overall performance, desirable driveability, rapid response, improved stability and added fuel economy. In this paper, an attempt is made to accomplish lower drag coefficient by incorporating the dimples shape on the vehicle roof surface. Aerodynamic flow analysis was conducted with and without dimple shape effect on a bus truck trailer and commercial vehicles, using ANSYS Fluent software tool. Effect of different sized and shaped dimples on aerodynamic performance was analysed as well. Results obtained were validated with available literature and it is found that coefficient of drag obtained showed less than 10 % error. It was found that drag values were significantly reduced with dimple effect on both the commercial vehicles. Both models demonstrated that the fluid flowing on the surface did not separate from the vehicle roof, and the vortex size at the back was reduced. Further paper gives a detailed study of various parameters like turbulence model effect, pressure distribution on the vehicles, temperature and mach number variations. This study is proposed to enhance energy efficiency of the automobiles as better aerodynamics improves their mileage and fuel economy.
Heavy metal absorption in the leaves of evergreen trees (Saraca asoca and Syzygium cumini) in Kanchipuram town, Tamil Nadu, India
Authors: Ramesh Sumathi , Gopalsamy Sriram
Published: December 2022

Plant species can be utilized for biomonitoring the quality of the environment and reform the extent of pollution in both urbanized and industrial regions. In this current study, the quantity of nine heavy metal components viz. Al, As, Cd, Cr, Cu, Fe, Mn, Zn, and Pb absorbed on the leaves of Saraca asoca and Syzygium cumini were examined by using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) during “February-March, 2019”. The samples were gathered from six different sites namely, Vellagate (Site1), CSI hospital (Site2), Near Cancer Institute (Site3), Moongilmandapam (Site4), Collectrate (Site5), Pallavarmedu (Control Site 6), of the Kanchipuram town, Tamil Nadu State. Metals Fe, Al, Zn and Mn were identified on the leaves of S.asoca and S.Cumini in all sites with varying concentrations out of which Fe (234.49mg/kg) and Al (364.18mg/kg) were higher level. Pb was identified only on the leaves of S.asoca in the sites 2 (2.21mg/kg) and site 4 (2.81mg/kg) which are subjected to heavy traffic and Cu was found only in site 3 and site 4 with minimum levels. The metals such as As, Cd, Cr was not identified on both species in all selected sites. Absorption of heavy metals on the leaves was probably due to emissions from vehicle, nonemission sources and mainly from other man-made activities. This work showed that both the selected species S.asoca and S.Cumini were suitable bio indicators, bio-monitors and used as greenbelt around the industrial areas for the mitigation of pollutants in the environment.
Automatic rainwater collecting duct
Authors: Hari B.S. , Shrivathsan V. , Tamilselvan S. , Sathiyan S.C.
Published: December 2022

Today conserving water has become an important issue to solve. Despite taking numerous measures, a viable solution has yet to be discovered. Everyone should be aware of the importance of adopting a water conservation plan. Many rainwater harvesting devices were common in many regions around the world in previous years. However, there is still no reliable way for collecting high-quality rainwater. Physically controlled gadgets are difficult to manipulate according to the user’s needs. So, this project was designed as automatic rainwater collecting duct. The collecting duct contains solid waste like leave and sediments which block the pathway of the water and reduce the quality of rainwater so make the automation in that duct. First of all, the duct is in the downward position by using rain sensor will detect the rain and as the output locomotive mechanism works which rotate a duct in 180-degree upside and purely collect the rainwater after the rain stops the duct rotates another 180 degrees and it back to the initial position of downward, in this way the duct is out of the solid waste stagnant and the collected rainwater is in good quality. The collected water can be stored in a copper tank that is contaminated purely. It can be used for drinking after the first stage of the purification of rainwater.
Development of Hermaphrodite Salacca (Salacca zalacca) SNAP Marker: A Novel Conservation Tool
Authors: Prihatini Riry , Dinarti Diny , Sutanto Agus , Sudarsono
Published: December 2022

Salacca (Salacca zalacca) or snake fruit is a tropical fruit, which is considered to be originated from Indonesia. One of the challenges in salacca conservation is the wide genetic diversity of the plants due to their natural cross-breeding. Most S. zalacca are dioecious plants by having fertile female and male flowers on different individuals, except for Salak Bali which is regarded to be monoecious. Morphological and cytogenetic markers have failed to differentiate the salacca plants’ sex types during the vegetative phase, thus the molecular marker is an alternative. We explored the specific salacca gene sequence on various sex types of salacca plants to identify sex-related single nucleotide polymorphism. The SNAP markers were then developed using the chosen SNP and validated on a total of 30 salacca samples. Nine samples of salacca’s female, male, and hermaphrodites were amplified using designed primers. The produced bands were sequenced and analyzed using Geneious Prime software. The analysis implied 9 SNPs on the 446 bp of salacca’s specific partial sequences. The SNAP markers were designed based on SNP validation showed that the marker potentially used a hermaphrodite-specific marker. The development of molecular markers as an early salacca sex type detection tool may be helpful in fruit cultivation, accelerating the plant breeding program, as well as on conservation management.
Terminalia catappa Linn Seed Yogurt with Honey Substitution for Food Security
Authors: Damayanti A , Bahlawan Z A S , Putri A , Salwa D F , Nurjaya N
Published: December 2022

Tropical almond nut (Terminalia catappa Linn) seeds have potential to be developed into yogurt because has a high nutritional content. In addition, honey has potential to be used as substitute for sugar in process of making yogurt. This research aims to determine effect of variations concentration honey in Tropical almond nut seed yogurt on the protein content to achieve food security. Variation of addition honey in this research is 6% (w/v), 8% (w/v), and 10% (w/v). Analysis protein content carried out using Kjeldahl method. The results showed that protein content in Tropical almond nut seed yogurt with addition of honey with concentration of 6% (w/v) is 3.06%, 8% (w/v) is 3.11%, and 10% (w/v) is 3.116%. These results had met the requirements of Indonesian National Standards (SNI) number 2981: 2009. The highest protein content was found in yogurt with the addition of 10% (w/v) honey with analysis result of 3.13%.
A collaborative governance model for bioethanol research and innovation ecosystem
Authors: Kusumawardhani D , Asmara A Y , Purwadi  , Pradana A W , Indriasari D T
Published: December 2022

Bioethanol can help Indonesia achieve its sustainability goals. Unfortunately, the success of bioethanol as Indonesia’s primary renewable energy system encounters a significant roadblock to play its strategic role as the main energy system in the country. This research investigates whether or not collaborative governance may contribute to the improvement of bioethanol as Indonesia’s significant renewable energy system from the research and innovation ecosystem perspectives. Going beyond, this research also elaborates the mechanisms and challenges. Local resources (including leadership and indigenous knowledge) and governance structures (such as social networks) as critical sectors can collaborate to create a productive cooperation. The report finds that a broader approach emphasizing transparency and breaking up the organization of the innovation ecosystem is needed so that Indonesia becomes a country with a more sustainable energy system.
Arrangements of a plane 𝑀-sextic with respect to a line
Authors: Orevkov S.
Published: December 2022

The mutual arrangements of a real algebraic or real pseudoholomorphic plane projective

M
M

-sextic and a line up to isotopy are studied. A complete list of pseudoholomorphic arrangements is obtained. Four of them are proved to be algebraically unrealizable. All the others with two exceptions are algebraically realized.
The eigensplitting of the fiber of the cyclotomic trace for the sphere spectrum
Authors: Blumberg Andrew , Mandell Michael
Published: December 2022

Let

p
∈

Z

p\in {\mathbb {Z}}

be an odd prime. We show that the fiber sequence for the cyclotomic trace of the sphere spectrum

S

{\mathbb {S}}

admits an “eigensplitting” that generalizes known splittings on

K
K

-theory and

T
C

TC

. We identify the summands in the fiber as the covers of

Z

p

{\mathbb {Z}}_{p}

-Anderson duals of summands in the

K
(
1
)

K(1)

-localized algebraic

K
K

-theory of

Z

{\mathbb {Z}}

. Analogous results hold for the ring

Z

{\mathbb {Z}}

where we prove that the

K
(
1
)

K(1)

-localized fiber sequence is self-dual for

Z

p

{\mathbb {Z}}_{p}

-Anderson duality, with the duality permuting the summands by

i
↦
p
−
i

i\mapsto p-i

(indexed mod

p
−
1

p-1

). We explain an intrinsic characterization of the summand we call

Z
Z

in the splitting

T
C
(

Z

)

p

∧

≃
j
∨
Σ

j
′

∨
Z

TC({\mathbb {Z}})^{\wedge }_{p}\simeq j \vee \Sigma j’\vee Z

in terms of units in the

p
p

-cyclotomic tower of

Q

p

{\mathbb {Q}}_{p}

.
Fabry disease with atypical phenotype identified by massively parallel sequencing in early-onset kidney failure
Authors: de Haan Amber , Morel Chantal F , Eijgelsheim Mark , de Jong Margriet F C , Broekroelofs Jan , Vogt Liffert , Knoers Nine V A M , de Borst Martin H
Published: December 2022

Background

The cause of chronic kidney disease (CKD) remains unknown in ∼20% of patients with kidney failure. Massively parallel sequencing (MPS) can be a valuable diagnostic tool in patients with unexplained CKD, with a diagnostic yield of 12%–56%. Here, we report the use of MPS to establish a genetic diagnosis in a 24-year-old index patient who presented with hypertension, nephrotic-range proteinuria and kidney failure of unknown origin. Additionally, we describe a second family with the same mutation presenting with early-onset CKD.

Results

In Family 1, MPS identified a known pathogenic variant in GLA (p.Ile319Thr), and plasma globotriaosylsphingosine and α-galactosidase A activity were compatible with the diagnosis of Fabry disease (FD). Segregation analysis identified three other family members carrying the same pathogenic variant who had mild or absent kidney phenotypes. One family member was offered enzyme therapy. While FD could not be established with certainty as the cause of kidney failure in the index patient, no alternative explanation was found. In Family 2, the index patient had severe glomerulosclerosis and a kidney biopsy compatible with FD at the age of 30 years, along with cardiac involvement and a history of acroparesthesia since childhood, in keeping with a more classical Fabry phenotype.

Conclusion

These findings highlight the large phenotypic heterogeneity associated with GLA mutations in FD and underline several important implications of MPS in the work-up of patients with unexplained kidney failure.
First described mitral clip in an adult extracardiac Fontan patient: a case report
Authors: Haeffele Christiane L , Lui George K , Peng Lynn , Chan Frandics , Sharma Rahul P
Published: December 2022

Background

The use of transcatheter edge-to-edge repair (TEER) in patients with advanced heart failure has been shown to reduce hospitalizations and increase survival. As patients with Fontan circulations grow older, a significant proportion of them will develop severe atrioventricular (AV) valve regurgitation in the systemic ventricle. Conventional surgical repair and transplant carry high mortality risk for the adult Fontan patient with progressive heart failure.

Case summary

A 51-year-old female extracardiac Fontan patient developed severe AV valve regurgitation and progressive functional decline. Based on her operative risk for conventional surgical intervention or transplant, TEER using the Abbott MitraClip device was performed. The degree of mitral regurgitation was decreased from severe to moderate regurgitation.

Discussion

This is the first known case describing the use of a successful TEER in an adult patient with an extracardiac Fontan. Given the increasing numbers of patients surviving into adulthood with a Fontan circulation, transcatheter interventions may provide an alternative treatment option to conventional surgeries and medical therapies.
Ten years’ experience with the sutureless aortic valve replacement: incidence and predictors for survival and valve durability at follow-up
Authors: Pollari Francesco , Mamdooh Hazem , Hitzl Wolfgang , Grossmann Irena , Vogt Ferdinand , Fischlein Theodor
Published: December 2022

OBJECTIVES

Aortic valve replacement with a sutureless prosthesis [sutureless aortic valve replacement (Su-AVR)] is an option for patients with severe aortic valve stenosis. However, data regarding long-term outcomes and prosthesis durability are still lacking.

METHODS

All consecutive patients who successfully underwent Su-AVR with the Perceval valve in our centre between 2010 and 2020 were included in the analysis and followed prospectively with echocardiography. Risk factor analysis was performed to assess variables associated with worse survival and bioprosthetic valve failure.

RESULTS

Study population consisted of 547 patients: the mean age was 76.4 (5.2) years, 51% were female and the mean logistic EuroSCORE was 13% (11). The median survival was 7.76 years [95% confidence interval (CI) = 6.9–8.6]. Risk factor analysis identified age [hazard ratio (HR) 1.06, 95% CI 1.03–1.11; P < 0.001), EuroSCORE II (HR 1.08, 1.02–1.13; P < 0.001), baseline dialysis (HR 2.14, 95% CI 1.4–4.4; P = 0.038) and postoperative acute kidney injury ≥2 (HR 8.97, 95% CI 4.58–17.6; P < 0.001) as factors significantly correlated with worse survival. The reported HRs for age are per 1 year and for EuroSCORE II is 1 percentage point. Structural valve deterioration (SVD) was observed in 23 patients, of whom 19 underwent reintervention (median freedom from SVD 10.3 years). In multivariable Cox analysis, age (HR 0.89, 95% CI 0.82–0.95; P < 0.001) was found to be a significant predictor of SVD. Overall, 1.8% was referred for prosthetic valve endocarditis (confirmed or suspected) during follow-up. One patient showed moderate non-SVD and none developed prosthetic valve thrombosis.

CONCLUSIONS

The sutureless valve represents a reliable bioprosthesis for aortic valve replacement in patients with a 10-year life expectancy. Younger age at the time of implant is the only factor associated with the risk of long-term SVD.
Extended-Spectrum β-Lactamase–Producing Escherichia coli in Neonates and Listeria monocytogenes in Young Children with Bacterial Meningitis in Japan
Authors: Furuichi Munehiro , Yaginuma Mizuki , Shinjoh Masayoshi , Ohnishi Takuma , Takahashi Takao , Iwata Satoshi
Published: December 2022

Nationwide surveillance of pediatric bacterial meningitis in Japan from 2019 to 2021 revealed two uncommon situations not covered by the recommended empiric treatment that were not rare in Japan, namely, extended-spectrum β-lactamase–producing-producing Escherichia coli in neonates and Listeria monocytogenes in children older than 1 month.
Multidisciplinary Approach to Improve Human Immunodeficiency Virus and Syphilis Testing Rates in Emergency Departments
Authors: Erickson Jessica L , Wu Janet , Fertel Baruch S , Pallotta Andrea M , Englund Kristin , Shrestha Nabin K , Lehman Bethany
Published: December 2022

Background

Best practice guidelines recommend that patients at risk for sexually transmitted infections (STIs), such as gonorrhea (GC) and chlamydia, should also be tested for human immunodeficiency virus (HIV) and syphilis. This prospective quality assurance study aimed to increase HIV and syphilis testing rates in emergency departments (EDs) across the Cleveland Clinic Health System from January 1, 2020 through January 1, 2022.

Methods

A multidisciplinary team of emergency medicine, infectious diseases, pharmacy, and microbiology personnel convened to identify barriers to HIV and syphilis testing during ED encounters at which GC/chlamydia were tested. The following interventions were implemented in response: rapid HIV testing with new a workflow for results follow-up, a standardized STI-screening order panel, and feedback to clinicians about ordering patterns.

Results

There were 57 797 ED visits with GC/chlamydia testing completed during the study period. Human immunodeficiency virus testing was ordered at 5% of these encounters before the interventions were implemented and increased to 8%, 23%, and 36% after each successive intervention. Syphilis testing increased from 9% before the interventions to 12%, 28%, and 39% after each successive intervention. In multivariable analyses adjusted for age, gender, and location, the odds ratio for HIV and syphilis testing after all interventions was 11.72 (95% confidence interval [CI], 10.82–12.71; P ≤.001) and 6.79 (95% CI, 6.34–7.27; P ≤.001), respectively.

Conclusions

The multidisciplinary intervention resulted in improved testing rates for HIV and syphilis.