bluuebunny/crossref_metadata_2025 huggingface dataset:
Congenitally corrected transposition of great arteries: anaesthesia management for a double heart valve replacement
Authors: Dai Bingling , Liu Xiang , Zhao Xiang , Bischof Evelyne , Ding Jiajun , Lu Huihong
Published: July 2023

Purpose

Congenitally corrected transposition of the great arteries (ccTGA) is a rare disease that is complicated by a variety of tachyarrhythmias or atrioventricular blocks and cardiac malformations. Anesthesia management is a challenge, especially in ccTGA patients with complications. Herein, we reported a case of ccTGA.

Methods

Multimodal general anesthesia combined with transversus thoracic muscle plane block (TTMPB), use of low-dose opioids and adjuvant medications, lung protective ventilation, use of vasoactive drugs and close perioperative monitoring were employed for the peri-operative management of this patient.

Results

The patient was safely returned to the ward and did not develop serious complications. Fourteen days after surgery, the patient recovered well and was discharged.

Conclusions

For patients undergoing a secondary cardiac surgery for ccTGA, preoperative evaluation of etiology of ccTGA is very important. Anesthesia management based on the surgical method and intraoperative vital signs and the postoperative real-time monitoring are also crucial for the post-operative recovery of these patients.
Brooding over Bloody Revenge
Authors: Taylor Nikki M.
Published: July 2023

From the colonial through the antebellum era, enslaved women in the US used lethal force as the ultimate form of resistance. By amplifying their voices and experiences, Brooding over Bloody Revenge strongly challenges assumptions that enslaved women only participated in covert, non-violent forms of resistance, when in fact they consistently seized justice for themselves and organized toward revolt. Nikki M. Taylor expertly reveals how women killed for deeply personal instances of injustice committed by their owners. The stories presented, which span centuries and legal contexts, demonstrate that these acts of lethal force were carefully pre-meditated. Enslaved women planned how and when their enslavers would die, what weapons and accomplices were necessary, and how to evade capture in the aftermath. Original and compelling, Brooding Over Bloody Revenge presents a window into the lives and philosophies of enslaved women who had their own ideas about justice and how to achieve it.
Order and Rivalry
Authors: Dungy Madeleine Lynch
Published: July 2023

The First World War transformed the legal and geopolitical framework for international trade by decentring Europe in global markets. Order and Rivalry traces the formation and development of multilateral trade structures in the aftermath of the First World War in response to the marginalization of Europe in the world economy, the use of private commerce as a tool of military power and the collapse of empires across Central and Eastern Europe. In this accessible study, Madeleine Lynch Dungy highlights the 1920s as a pivotal transition phase between the network of bilateral trade treaties that underpinned the first globalization of the late nineteenth century and the institutionalised regime of international governance after 1945. Focusing on the League of Nations, she shows that this institution's legacy was not to initiate a linear forward march towards today's World Trade Organization, but rather to frame an open-ended and conflictual process of experimentation that is still ongoing.
Why the Bible Began
Authors: Wright Jacob L.
Published: July 2023

Why did no other ancient society produce a text remotely like the Bible? That a tiny, out of the way community, could have produced a text so determinative for peoples across the globe seems improbable.For Jacob Wright, the Bible is not only a testimony of survival, but also an unparalleled achievement in human history. Forged during Babylonian exile after the shattering destruction of Jerusalem, it makes not victory but total humiliation the foundation of a new idea of belonging. Lamenting the destruction of their homeland, scribes who composed the Bible turned to the golden ages of the past, reflecting deeply on abject failure. More than just religious scripture, the Bible is a resonant blueprint for the inspiring creation of a nation. As a response to catastrophe, it offers a powerful, message of hope and restoration that is unique in the Ancient Near Eastern and Greco-Roman worlds. Wright's Bible is thus a social, political, and even economic roadmap – one that enabled a small and obscure community located on the periphery of leading civilizations and empires, not just to come back from the brink, but ultimately to shape the world's destiny. The Bible speaks ultimately of being a united, yet diverse people, and its pages present a manual of pragmatic survival strategies in response to societal collapse.
The Making of Modern Property
Authors: di Robilant Anna
Published: July 2023

In this original intellectual history, Anna di Robilant traces the history of one of the most influential legal, political, and intellectual projects of modernity: the appropriation of Roman property law by liberal nineteenth-century jurists to fit the purposes of modern Europe. Drawing from a wealth of primary sources, many of which have never been translated into English, di Robilant outlines how a broad network of European jurists reinvented the classical Roman concept of property to support the process of modernisation. By placing this intellectual project within its historical context, she shows how changing class relations, economic policies and developing ideologies converged to produce the basis of modern property law. Bringing these developments to the twentieth century, this book demonstrates how this largely fabricated version of Roman property law shaped and continues to shape debates concerning economic growth, sustainability, and democratic participation.
A new Cambrian (Jiangshanian, Sunwaptan) trilobite fauna from Oklahoma and its biostratigraphic significance.
Authors: Blackwell Sean R. , Westrop Stephen R.
Published: July 2023

The Cambrian (Jiangshanian, Sunwaptan) Honey Creek Formation in the Wichita Mountains region of Oklahoma yielded a new fauna dominated by Monocheilus Resser, 1937 (senior synonym of Stigmacephalus Resser, 1937) in association with Ptychaspis Hall, 1863. It occupies the same stratigraphic position as similar faunas in the Upper Mississippi Valley and Alberta, lying a little above an interval characterized by species of Taenicephalus Ulrich and Resser in Walcott, 1924 and Orygmaspis Resser, 1937. Revision of Ptychaspis bullasa Lochman and Hu, 1959 from type material from Idaho and sclerites attributed to the species from Texas reveals a plexus of pseudocryptic species that share tuberculate sculpture on the cranidium. New species are Monocheilus reginae, Monocheilus richardi, Ptychaspis occulta, and Ptychaspis matuszaki.

UUID: www.zoobank.org/c2771c63-db4b-434a-ae58-3e3fda19ecb0
Material nature or perversion: the case of aluminium
Authors: Emmons Paul , Terim Berrin
Published: July 2023

Building materials both derive from nature and human culture. Although this categorisation often assumes a binary opposition; it should be reminded that natural materials have always been utilised for architectural design through human faculty embedded in cultural knowledge. On the other hand, modern materials produced via destructive industrial means, credited to human culture, do reveal their inherent ‘nature’ in their various applications and in different climatic conditions. Acknowledging the inherent intertwining of nature and culture in building materials, this article discusses the reasoning and moral language embedded in architectural theories regarding material use in design, through the angle of perversion. Based on its various definitions, interpreted as unnatural, abnormal and contingent, the article approaches this multifaceted topic, through examining aluminium; an industrially produced modern material that is conceptually malleable. The transformation of aluminium’s use in architecture and its perception throughout its short history presents a fruitful case for understanding many-sided arguments regarding material applications to formal design approaches and thinking with/through material in order to design.
Cathedrals on the light of a butterfly’s wing: the momentary architecture of Virginia Woolf
Authors: Carr Andrew
Published: July 2023

When discussing ‘How Should One Read a Book?’, Virginia Woolf describes the work of an author as ‘an attempt to make something as formed and controlled as a building‘, using architecture as an analogy for the structure of a literary work. The ‘formed and controlled‘ structures of Woolf‘s books are here explored through her 1927 novel To the Lighthouse, which she was writing around the same time as her essay on ‘How Should One Read a Book?‘ and for which she drew a diagram of its tripartite structure. While Woolf repeatedly uses imagery that juxtaposes transitory life with fixed buildings, her writing also suggests another more complex, fleeting architecture. This is revealed through an examination of the temporal structures of her novels and the momentary architecture that forms around its inhabitants. The decay and renewal of the house in the middle section of To the Lighthouse extends this further, revealing a precariousness that undermines the qualities of control, constancy, and permanence she had assumed for a building and, by analogy, her ‘formed and controlled‘ structures. Architecture, instead, becomes momentary and precarious. An assembly of architectural short stories reflect on this reversal as they are ‘read‘ by To the Lighthouse – developing the dialogue between the writing of architecture and building of literature, between architectural possibility and the world-making of words within a book. New College Library by Níall McLaughlin, Ursula Meier‘s film Home, the Marshall House by Dow Jones and the Snellman House by Erik Gunnar Asplund are discussed. The study combines a close reading of the text with a drawn analysis that maps To the Lighthouse and Woolf‘s novels while also reconstructing places she inhabited.
Regional Scale, Fault‐Related Fluid Circulation in the Ionian Zone of the External Hellenides Fold‐And‐Thrust Belt, Western Greece: Clues for Fluid Flow in Fractured Carbonate Reservoirs
Authors: Smeraglia Luca , Bernasconi Stefano , Manniello Canio , Spanos Dimitris , Pagoulatos Aristotelis , Aldega Luca , Kylander‐Clark Andrew , Jaggi Madalina , Agosta Fabrizio
Published: July 2023

We combined field mapping, structural and microstructural analyses, stable‐clumped isotope geochemistry, and U‐Pb dating of calcite veins and syn‐tectonic slickenfibres, to assess the regional scale fault‐related fluid flow during the evolution of the External Hellenides fold‐and‐thrust belt. We show that fluid circulation during forebulge uplift was characterized by cold meteoric water‐derived fluids, from which calcite precipitated and sealed bed‐perpendicular joints. Fluid circulation during foreland flexuring and early layer‐parallel shortening was characterized by warm fluids buffered by the carbonate host rock, which circulated through normal faults and bed‐parallel veins. Mixing with meteoric‐derived fluids also occurred at this stage of tectonic evolution. Fluid circulation during the late stage of thrust wedge accretion and post‐orogenic extension at 1.6 ± 1 Ma was characterized by increasing dominance of cold meteoric water circulating in strike‐slip and normal faults. The ingress of meteoric‐derived fluids was controlled by throughgoing fault conduits, while host rock‐buffered fluids were confined in isolated structures such as minor faults and veins. We developed a conceptual model of fault‐related fluid circulation, which invokes a transition from an open fluid system during forebulge uplift, to a semi‐closed fluid system during foreland flexuring and early layer‐parallel shortening, and to an open system during late thrust wedge accretion and post‐orogenic extension. This type of fluid circulation may have impacted fluid migration/leakage, including hydrocarbons, into or outside potential reservoirs in the highly prospective Hellenides‐Albanides fold‐and‐thrust belt, a renovated frontier for hydrocarbon exploration in the Mediterranean area.
Acute changes in antioxidants and oxidative stress to vigorous arm exercise: an intervention trial in persons with spinal cord injury and healthy controls
Authors: Wouda Matthijs F. , Slettahjell Hanne Bjørg , Lundgaard Eivind , Bastani Nasser E. , Raastad Truls , Blomhoff Rune , Kostovski Emil
Published: July 2023

Study design

Intervention trial.

Background

Literature remains unclear on possible health benefits and risks assosciated with high intensity exercise for persons with SCI. Elevated oxidative stress levels might influence their ability to exercise at high intensity. We investigated several biomarkers of oxidative stress and antioxidant defense at rest, during and after vigorous exercise among persons with chronic SCI.

Setting

Sunnaas Rehabilitation Hospital, Norway.

Methods

Six participants (five males) with chronic SCI (AIS A, injury level thoracic 2–8, >1 year postinjury) and six matched able-bodied controls performed two maximal arm-cranking tests, with one-three days in between. During the second exercise test, participants performed three bouts with four minutes arm cranking at high intensity (85–95% of peak heart rate (HRpeak)), before they reached maximal effort. Blood and urine biomarkers for oxidative stress and antioxidant levels were collected at six time points at the day of the second exercise test; baseline, at high intensity exercise, at maximal effort, at five, 30 and 60 min post-exercise, and 24 h post exercise.

Results

Participants with SCI had significant lower levels of creatinine (∆16 µmol/L, p = 0.03), α-carotene (∆0.14 nmol/L, p < 0.001) and β-carotene (∆0.51 nmol/L, p = 0.001) at baseline compared to controls. Urine and blood biomarkers of oxidative stress and antioxidant levels showed similar response to vigorous exercise in the SCI and control group.

Conclusions

SCI participants showed similar changes in redox status during high intensity exercise compared to matched able-bodied. SCI participants had lower levels of exogen antioxidants both before, during and after vigorous exercise.
Hyphosphere microorganisms facilitate hyphal spreading and root colonization of plant symbiotic fungus in ammonium-enriched soil
Authors: Sun Kai , Jiang Hui-Jun , Pan Yi-Tong , Lu Fan , Zhu Qiang , Ma Chen-Yu , Zhang Ai-Yue , Zhou Jia-Yu , Zhang Wei , Dai Chuan-Chao
Published: July 2023

Anthropogenic nitrogen inputs lead to a high ammonium (NH4+)/nitrate (NO3−) ratio in the soil, which restricts hyphal spreading of soil fungi. Access of symbiotic fungi to roots is a prerequisite for plant-fungal interactions. Hyphosphere bacteria protect fungi from environmental stress, yet the impact of hyphosphere bacteria on adaptation of host fungi to NH4+-enriched conditions remains unclear. By developing soil microcosm assays, we report that a plant-symbiotic fungus, Phomopsis liquidambaris, harbors specific hyphosphere bacteria that facilitate hyphal spreading and assist in the root colonization in NH4+-enriched soil. Genetic manipulation, 16S rRNA gene analysis and coinoculation assays revealed that the genus Enterobacter was enriched in the hyphosphere of NH4+-sensitive wild-type compared to NH4+-preferring nitrite reductase-deficient strain. The representative Enterobacter sp. SZ2-promoted hyphal spreading is only evident in nonsterilized soil. We further identified an increased abundance and diversity of ammonia-oxidizing archaea (AOA) and a synchronously decreased NH4+:NO3− ratio following SZ2 inoculation. Microbial supplementation and inhibitor assays showed that AOA-mediated reduction in NH4+:NO3− ratio is responsible for SZ2-enhanced fungal adaptation to NH4+-enriched conditions. The Ph. liquidambaris-Enterobacter-AOA triple interaction promoted rice growth in NH4+-enriched soil. Our study reveals the essential role of hyphosphere microorganism-based hyphal spreading in plant-fungal symbiosis establishment within nitrogen-affected agroecosystems.
Multi-center study on predicting breast cancer lymph node status from core needle biopsy specimens using multi-modal and multi-instance deep learning
Authors: Ding Yan , Yang Fan , Han Mengxue , Li Chunhui , Wang Yanan , Xu Xin , Zhao Min , Zhao Meng , Yue Meng , Deng Huiyan , Yang Huichai , Yao Jianhua , Liu Yueping
Published: July 2023

The objective of our study is to develop a deep learning model based on clinicopathological data and digital pathological image of core needle biopsy specimens for predicting breast cancer lymph node metastasis. We collected 3701 patients from the Fourth Hospital of Hebei Medical University and 190 patients from four medical centers in Hebei Province. Integrating clinicopathological data and image features build multi-modal and multi-instance (MMMI) deep learning model to obtain the final prediction. For predicting with or without lymph node metastasis, the AUC was 0.770, 0.709, 0.809 based on the clinicopathological features, WSI and MMMI, respectively. For predicting four classification of lymph node status (no metastasis, isolated tumor cells (ITCs), micrometastasis, and macrometastasis), the prediction based on clinicopathological features, WSI and MMMI were compared. The AUC for no metastasis was 0.770, 0.709, 0.809, respectively; ITCs were 0.619, 0.531, 0.634, respectively; micrometastasis were 0.636, 0.617, 0.691, respectively; and macrometastasis were 0.748, 0.691, 0.758, respectively. The MMMI model achieved the highest prediction accuracy. For prediction of different molecular types of breast cancer, MMMI demonstrated a better prediction accuracy for any type of lymph node status, especially in the molecular type of triple negative breast cancer (TNBC). In the external validation sets, MMMI also showed better prediction accuracy in the four classification, with AUC of 0.725, 0.757, 0.525, and 0.708, respectively. Finally, we developed a breast cancer lymph node metastasis prediction model based on a MMMI model. Through all cases tests, the results showed that the overall prediction ability was high.
Memory-like innate response to booster vaccination with MF-59 adjuvanted influenza vaccine in children
Authors: Kazmin Dmitri , Clutterbuck Elizabeth A. , Napolitani Giorgio , Wilkins Amanda L. , Tarlton Andrea , Thompson Amber J. , Montomoli Emmanuele , Lapini Guilia , Bihari Smiti , White Rachel , Jones Claire , Snape Matthew D. , Galal Ushma , Yu Ly-Mee , Rappuoli Rino , Del Giudice Giuseppe , Pollard Andrew J. , Pulendran Bali
Published: July 2023

The pediatric population receives the majority of vaccines globally, yet there is a paucity of studies on the transcriptional response induced by immunization in this special population. In this study, we performed a systems-level analysis of immune responses to the trivalent inactivated influenza vaccine adjuvanted with MF-59 in children (15–24 months old) and in young, healthy adults. We analyzed transcriptional responses elicited by vaccination in peripheral blood, as well as cellular and antibody responses following primary and booster vaccinations. Our analysis revealed that primary vaccination induced a persistent transcriptional signature of innate immunity; booster vaccination induced a transcriptional signature of an enhanced memory-like innate response, which was consistent with enhanced activation of myeloid cells assessed by flow cytometry. Furthermore, we identified a transcriptional signature of type 1 interferon response post-booster vaccination and at baseline that was correlated with the local reactogenicity to vaccination and defined an early signature that correlated with the hemagglutinin antibody titers. These results highlight an adaptive behavior of the innate immune system in evoking a memory-like response to secondary vaccination and define molecular correlates of reactogenicity and immunogenicity in infants.
SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks
Authors: Bravo González-Blas Carmen , De Winter Seppe , Hulselmans Gert , Hecker Nikolai , Matetovici Irina , Christiaens Valerie , Poovathingal Suresh , Wouters Jasper , Aibar Sara , Aerts Stein
Published: July 2023

Joint profiling of chromatin accessibility and gene expression in individual cells provides an opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present a method for the inference of enhancer-driven GRNs, called SCENIC+. SCENIC+ predicts genomic enhancers along with candidate upstream transcription factors (TFs) and links these enhancers to candidate target genes. To improve both recall and precision of TF identification, we curated and clustered a motif collection with more than 30,000 motifs. We benchmarked SCENIC+ on diverse datasets from different species, including human peripheral blood mononuclear cells, ENCODE cell lines, melanoma cell states and Drosophila retinal development. Next, we exploit SCENIC+ predictions to study conserved TFs, enhancers and GRNs between human and mouse cell types in the cerebral cortex. Finally, we use SCENIC+ to study the dynamics of gene regulation along differentiation trajectories and the effect of TF perturbations on cell state. SCENIC+ is available at scenicplus.readthedocs.io.
A comparison of the biomechanical properties of three different lumbar internal fixation methods in the treatment of lumbosacral spinal tuberculosis: finite element analysis
Authors: Liu Jiantao , Gong Xi , Wang Kao , Li Xingyuan , Zhang Xiwei , Sun Jiajun , Zhu Yihan , Ai Yixiang , Ren Jing , Xiu Jintao , Ji Wenchen
Published: July 2023

There are various internal fixation methods in treating lumbosacral spinal tuberculosis. The study compared the stability and stress distribution in surrounding tissues/implants, such as discs, endplates and screw-rod internal fixation system, etc. when applying three different lumbar internal fixation methods to treat lumbosacral spinal tuberculosis. A finite element model was constructed and validated. The spinal stability was restored using three methods: a titanium cage with lateral double screw-rod fixation (group 1), autologous bone with posterior double screw-rod fixation (group 2), and a titanium cage with posterior double screw-rod fixation (group 3). For comparison, group 4 represented the intact L3-S1 spine. Finally, a load was applied, and the ranges of motion and Von Mises stresses in the cortical endplates, screw-rod internal fixation system and cortical bone around the screws in the different groups were recorded and analyzed. All six ranges of motion (flexion, extension, left/right lateral bending, left/right rotation) of the surgical segment were substantially lower in groups 1 (0.53° ~ 1.41°), 2 (0.68° ~ 1.54°) and 3 (0.55° ~ 0.64°) than in group 4 (4.48° ~ 10.12°). The maximum stress in the screw-rod internal fixation system was clearly higher in group 2 than in groups 1 and 3 under flexion, left/right lateral bending, and left/right rotation. However, in extension, group 1 had the highest maximum stress in the screw-rod internal fixation system. Group 2 had the lowest peak stresses in the cortical endplates in all directions. The peak stresses in the cortical bone around the screws were higher in group 1 and group 2 than in group 3 in all directions. Thus, titanium cage with posterior double screw-rod fixation has more advantages in immediate reconstruction of lumbosacral spinal stability and prevention of screw loosening.
Adynamic response to cold pain reflects dysautonomia in type 1 diabetes and polyneuropathy
Authors: Arendt Nielsen Thomas , Lundbye-Christensen Søren , Krasimirova Dimitrova Yoanna , Riahi Sam , Brock Birgitte , Mohr Drewes Asbjørn , Brock Christina
Published: July 2023

Cardiac autonomic neuropathy (CAN), widely assessed by heart rate variability (HRV), is a common complication of long-term diabetes. We hypothesized that HRV dynamics during tonic cold pain in individuals with type 1 diabetes mellitus (T1DM) could potentially demask CAN. Forty-eight individuals with long-term T1DM and distal symmetrical polyneuropathy and 21 healthy controls were included. HRV measures were retrieved from 24-h electrocardiograms. Moreover, ultra-short-term HRV recordings were used to assess the dynamic response to the immersion of the hand into 2 °C cold water for 120 s. Compared to healthy, the T1DM group had expectedly lower 24-h HRV measures for most components (p < 0.01), indicating dysautonomia. In the T1DM group, exposure to cold pain caused diminished sympathetic (p < 0.001) and adynamic parasympathetic (p < 0.01) HRV responses. Furthermore, compared to healthy, cold pain exposure caused lower parasympathetic (RMSSD: 4% vs. 20%; p = 0.002) and sympathetic responses (LF: 11% vs. 73%; p = 0.044) in the T1MD group. QRISK3-scores are negatively correlated with HRV measures in 24-h and ultra-short-term recordings. In T1DM, an attenuated sympathovagal response was shown as convincingly adynamic parasympathetic responses and diminished sympathetic adaptability, causing chronometric heart rhythm and rigid neurocardiac regulation threatening homeostasis. The findings associate with an increased risk of cardiovascular disease, emphasizing clinical relevance.
Training data size and predication errors in the use of machine-learning assisted intraocular lens power calculation
Authors: Tabuchi Hitoshi , Yamauchi Tomofusa , Shojo Tomohiro , Takase Kosuke , Tanabe Mao
Published: July 2023

This retrospective study examined the effect of the size of training data on the accuracy of machine learning-assisted SRK/T power calculation. Clinical records of 4800 eyes of 4800 Japanese patients with intraocular lenses (IOLs) were reviewed. A support vector regressor (SVR) was used for refining the SRK/T formula, and dataset sizes for training and evaluation were reduced from full to 1/64. The prediction errors from the postoperative refractions were calculated, and the proportion within ± 0.25 D, ± 0.50 D, and ± 1.00 D of errors were compared with those using full data. The influence of the difference in A-constant was also evaluated. Prediction errors within ± 0.50 D in the use of full data were obtained with the dataset of ≥ 150 eyes (P = 0.016), whereas the datasets of ≥ 300 eyes were required for the error within ± 0.25 D (P < 0.030). The prediction errors did not alter with the A-constant values among IOLs with open-loop haptics, except for IOLs with plated haptics. In conclusion, the accuracy of SVR-assisted SRK/T could be achieved with the training dataset of ≥ 150 eyes for the Japanese population, and the calculation was versatile for any open-looped IOLs.
A stable and strongly ferromagnetic Fe17O10– cluster with an accordion-like structure
Authors: Geng Lijun , Yu Xiaohu , Luo Zhixun
Published: July 2023

Isolated clusters are ideal systems for tailoring molecule-based magnets and investigating the evolution of magnetic order from microscopic to macroscopic regime. We have prepared pure Fen– (n = 7-31) clusters and observed their gas-collisional reactions with oxygen in a flow tube reactor. Interestingly, only the larger Fen– (n ≥ 15) clusters support the observation of O2-intake, while the smaller clusters Fen– (n = 7-14) are nearly nonreactive. What is more interesting is that Fe17O10– shows up with prominent abundance in the mass spectra indicative of its distinct inertness. In combination with DFT calculations, we unveil the stability of Fe17O10– within an interesting acordion-like structure and elucidate the spin accommodation in such a strongly ferromagnetic iron cluster oxide.
The prevalence of Dupuytren’s disease in patients with diabetes mellitus
Authors: Ganesan Sandhya , Tantone Ryan P. , Komatsu David E. , Hurst Lawrence C.
Published: July 2023

Background

Dupuytren’s disease (DD) is a fibroproliferative hand disorder associated with various medical conditions, including diabetes mellitus (DM). The reported prevalence of DM among DD patients varies widely, primarily due to small sample sizes in previous studies.

Methods

This was a retrospective cohort study using data from the TriNetX Research Database. We analyzed the overall prevalence of DD between 2010 and 2020, comparing the DM, type 1 diabetes mellitus (T1DM), and type 2 diabetes mellitus (T2DM) cohorts. Within the DM group, patients were further categorized based on hemoglobin A1c (HbA1c) values and prescribed anti-diabetic agents (insulin or metformin). We compared the prevalence of DD diagnosis in each group using prevalence ratios and differences.

Results

There is a higher prevalence of DD in patients with T2DM than in patients with T1DM (relative risk [RR]: 1.641; 95% confidence interval [CI]: [1.356, 1.986]). Among patients with diabetes, there is a higher prevalence of DD in those taking insulin compared to those taking metformin (RR: 0.801, 95% CI: [0.774, 0.83]). The prevalence of DD varies depending on HbA1c levels, with a prevalence of 0.463% in patients having levels within the diabetic range, while lower prevalences of 0.392% and 0.416% are found in patients with prediabetes or uncontrolled diabetes, respectively.

Conclusions

This study provides further insight into the relationship between DM and DD. These findings may be attributed to the increased accumulation of advanced glycosylated end products (AGEs) in patients with diabetes. Future research exploring the connection between AGE accumulation and DD development may enhance our understanding of the relationship between DD and DM.
A polyoxometalate-based heterojunction nanozyme with peroxidase-mimic catalytic activity for sensitive biomolecule detection
Authors: Du Guobo , Lv Mingzhu , Wang Huan , Liu Chenghui , Xu Qiqi , Liu Jiajie , Yang Zhu , Yong Yuan , Han Yunwei
Published: July 2023

The heterojunction GdP5W30O110@WS2 possessing peroxidase (POD)-like catalytic activity was constructed as a reliable analytical platform for the detection of H2O2, glutathione (GSH) and glucose via a simple TMB colorimetric strategy.
V-doped porous CoP nanoarrays grown on carbon cloth with optimized electronic structure for the hydrogen evolution reaction
Authors: Jia Wenzhi , Lu Qian , Zheng Wenjun , Wang Kunyan , Liu Xinhua , Yang Shichun , He Bin
Published: July 2023

As an efficient, renewable and clean energy, hydrogen is expected to replace traditional fossil fuel energy in the future.
Preparation of zeolite-based porous materials via photopolymerization and their applications in 3D printing and gas storage
Authors: Zhang Yijun , Gao Yuanyuan , Josien Ludovic , Vaulot Cyril , Simon-Masseron Angélique , Lalevée Jacques
Published: July 2023

In this work, the LTA-5A zeolite and Al2O3 are used as fillers in composites prepared by photopolymerization.
Repurposing a long-wavelength fluorescent boronate probe for the detection of reactive oxygen species (ROS) in bacteria
Authors: Yan Kai-Cheng , Thet Naing , Heylen Rachel A. , Sedgwick Adam C. , James Tony D. , Jenkins A. Toby A. , He Xiao-Peng
Published: July 2023

A TCF boronate based probe developed for cellular imaging was repurposed to detect ROS in bacteria.
A phase-engineered nickel sulfide and phosphide (NiS–Ni2P) heterostructure for enhanced hydrogen evolution performance supported with DFT analysis
Authors: Das Jiban K. , Sahu Nachiketa , Mane Pratap , Chakraborty Brahmananda , Behera J. N.
Published: July 2023

A phase-engineered synthesis of a nickel sulfide and phosphide heterostructure (NiS–Ni2P) was carried out through a simple hydrothermal treatment, and its electrocatalytic performance towards the hydrogen evolution reaction was explored.
An efficient oxygen evolution reaction catalyst using Ni–Co layered double hydroxide anchored on reduced graphene oxide
Authors: Wakamatsu Sora , Islam Md. Saidul , Shudo Yuta , Fukuda Masahiro , Tagawa Ryuta , Goto Nonoka , Koinuma Michio , Sekine Yoshihiro , Hayami Shinya
Published: July 2023

An efficient oxygen evolution reaction (OER) catalyst has been reported from rGO anchored NiCo-LDH nanosheets.
Innovative Educational Technologies and the Use of Virtual Research Tools
Authors: Idrisova Jaradat , Alikhadzhiev Saidmagomed , Shudueva Zalina
Published: July 2023

This article explores the use of innovative educational technology, particularly virtual inquiry tools, to help students develop critical thinking skills. It examines the potential of these tools to provide access to multiple resources, allowing students to evaluate sources and draw their own conclusions. The article also discusses how virtual research tools can open up new research opportunities and help students think outside the box and find creative solutions. Finally, it discusses the importance of equipping teachers with the necessary knowledge and skills to use such technology effectively in their classrooms. Overall, innovative educational technologies such as virtual reality headsets and virtual research tools have revolutionized our children’s learning, making it more engaging and effective than ever before.
The Educational Process in the Aspect of the Study of Circular Economy
Authors: Burykina Marina , Danilova Tatyana , Lapyko Tatiana , Kamynin Vitaly , Tonkikh Alexander
Published: July 2023

Changes in the global economic model for the use of Natural Resources will increase mainly due to reductions on a point scale of about 90 billion USD native resources. It is expected to reach 190 billion USD by 2060. This will lead to a significant increase in carbon dioxide emissions and a reduction in raw materials needed for high technologies. The only way to counter these challenges is to move to a circular economy. Circular economics calls into question the linear system and requires a rethink of the production process, considering the process of recycling goods. It offers significant potential for innovation, employment opportunities, quality of work, and ultimately a more inclusive economy that serves the needs of all people. The role of the educational system in the process of forming a circular economy. The importance of education is emphasized in the transition to a circular economy. The education system is a key player in the transition from a linear to a circular economy, which should begin to guide this transformation. To do this, the education system must first adapt to new requirements by adopting circular economics teaching in classrooms. Secondly, to ensure an effective large-scale transition by developing students’ proper skills and systems thinking. However, circular economics cannot be tied to a single profession or discipline because its success requires dialogue between different actors. This is an inter-social economic model that is needed in the fields of engineering, design, military operations, and business. Therefore, the teaching of circular economics should also be interdisciplinary and cover different areas of Education.
Experience and Problems of Environmental Education, Education and Upbringing. Ecological Culture
Authors: Osmaev Movla
Published: July 2023

The article talks about the relationship of the Chechen people with nature, which from time immemorial were built on the fundamental principles of human community, and the worldview proceeded from the integrity of living and inanimate nature, as they are interconnected and mutually conditioned, therefore have an equal degree of importance for the harmonious functioning of the universe. Flora and fauna, micro- and macrocosm, living and inanimate, rational and irrational are part of a single system of the universe. In the natural environment, as well as in society, there is and cannot be anything that could be ignored. The problem of ecology in its relevance and significance has come to the fore, because today there is an unprecedented ecological crisis in the entire history of mankind. But despite this, people continue to blindly exploit natural resources, pollute the environment and the entire atmosphere. In these conditions, it is important to show that a distinctive feature of Chechen culture is a careful attitude to nature.
Formation of Ecological Consciousness of Students on the Basis of Reflective Technologies
Authors: Bulueva Sh. I. , Israilova S. A. , Magomedova M. A.
Published: July 2023

The article studies the process of formation of students’ ecological consciousness on the basis of reflective technologies. The content of the concepts of “reflection” and “nvironmental consciousness” is clarified and concretized. The main theoretical approaches to the formation of ecological consciousness of university students are revealed. The views of domestic and foreign teachers on the problem of using reflective technologies in the process of forming the ecological consciousness of a person are analyzed. Reflection is considered as one of the main components of creativity, as a result of which the student becomes the object of creative action for himself. On the basis of reflection, his self-development, the formation of his life path and the development of his consciousness take place. Based on this, when working with students with a low level of reflection, it is necessary to apply tasks based on co-creative reflective technologies of an ecological orientation, which will lead to an increase in the level of reflection and environmental awareness.
The Role of Strategic Planning in the Implementation of National Policy in the Russian Federation
Authors: Bezvikonnaya Elena , Bogdashin Alexander , Volokh Tamara , Portnyagina Elena
Published: July 2023

Strategic planning acts as a key tool for the preparation and implementation of national policy at the level of state and municipal administration. Given the limited resource capabilities of the budget system of the Russian Federation, the strategy allows us to purposefully solve the tasks set and ensures the implementation of the principle of a multinational state. The purpose of the study is to assess the organizational and legal potential of strategic planning of national policy at the level of the Russian Federation, its subjects and municipalities. The article provides for the application of an institutional approach that allows assessing the effectiveness of national policy management at different levels of public authority. The structural and functional method determined the possibility of evaluating the effectiveness of the national policy management structure. In the course of the research, the potential of the process of planning and implementing national policy is revealed. The scientific significance of the findings lies in the classification of the typology of national policy management in the region and the municipality. The novelty of the work is to identify the features of regional and municipal practices of national policy management.
Improving Quality of the Urban Environment as a Factor in Sustainable Development
Authors: Eskerkhanova Luiza
Published: July 2023

The global pandemic of a new coronavirus infection has affected not only the labor activity and social activity of the population, but also the economies of all countries without exception, seriously slowing down their growth rates, reducing production and electricity consumption, collapsing demand for raw materials and goods, and significantly reducing transport flows. All this had a direct impact on the reduction of pollutant emissions into the atmosphere and led to a short-term improvement in air quality. According to analysts at the British climate change portal Carbonbrief, the economic crisis caused by the pandemic could lead to the largest reduction in emissions on record. Already now this figure (in quantitative terms) is 6 times higher than during the global financial crisis of 2008, and more than 2 times higher than during the Second World War. As part of monitoring observations of the state and quality of ambient air during the pandemic and the introduction of restrictive measures, a significant decrease in the concentrations of pollutants around the world is recorded, especially in large cities and industrial centers.
Problems and Imbalances in the Field of Employment Management in Tatarstan and the Chechen Republic
Authors: Malganova I. G. , Dokhkilgova D. M. , Saralinova Dzh. S.
Published: July 2023

The relevance of the issue considered in the article lies in the fact that the structure of labor resources is a determining factor in the economic life of both a single territory and the entire state. At the same time, the formation and characteristics of labor resources are influenced by the economic and social policy of the state, its regulatory activities in the labor market, the amount of payment for the work performed, the demographic situation, and the level of qualification. The article analyzes differences in the structure of labor resources, qualitative and quantitative characteristics in regions such as the Chechen Republic and the Republic of Tatarstan.
Industry 4.0: The Fourth Industrial Revolution
Authors: Bekmurzaeva Rashiya , Kovalev G.S.
Published: July 2023

In the conditions of market volatility and a shortening of the life cycle of products, modern manufacturers are faced with the need to increase costs, accelerate and localize production processes. The answer to these challenges is offered by the fourth industrial revolution, or Industry 4.0 (I4.0). It consists in increasing the speed of bringing products to market through the transformation of the supply chain into highly adaptive integrated networks. The potential effect of I4.0 implementation on competitiveness (in particular, subsidiaries of foreign companies) and the nature of the modernization of global value chains, of which companies are a part, are considered on four specific examples. It is shown that in the I4.0 era, the competitive advantages of a business may depend both on the transformation of individual industries and on changes in relations between partners. These results are consistent with findings in the literature about the uncertainty and complexity of the digital economy in general, and confirm that there are problems with accurately assessing perceived benefits. I4.0 is based on the struggle for leadership, in which competitiveness is increased primarily by improving product quality, and not by reducing costs. At the same time, I4.0 contributes to the emergence of groups of closely interconnected, integrated with each other companies up to the erasure of clear boundaries between them.
Global Digital Transformation Trends in Real Sectors of the Economy
Authors: Murat Agaev , Saida Shardan , Timurlan Shailiev
Published: July 2023

Digital technologies cover an increasing number of areas of life, and therefore the digital revolution has a great impact on the economy both globally and nationally. An increasing number of digital companies are emerging in sectors of the economy using their own new business models and business processes, which distinguishes them from other market players and provides new competitive advantages. In this context, the survival of long-established companies in the market depends on factors such as the willingness to adapt to new models of customer relationships, change the production and value chain, and redefine their relationships with all stakeholders, introducing new technologies into these processes and creating its own innovative products and tools for business optimization. Innovation and new business models driven by the digital transformation of the economy can directly drive long-term growth and help address resource constraints.
Challenges for the Economic Security of the State in the Context of the Formation of the Digital Economy
Authors: Lazareva Natalia , Sultanov Garun , Orlova Ekaterina
Published: July 2023

The rapid pace of technological progress has created new opportunities for every person, enterprise and state in achieving their goals and interests. The digital economy is now considered as a component of the traditional one, and its share indicates the level of use of the latest digital technologies, which becomes the dominant factor for improving the competitive position of a certain country in the global economic space. The development of high-tech industrial production with the simultaneous digitalization of all areas of the socio-economic environment creates conditions for the further technological dominance of a limited circle of leading countries. At the same time, the changes caused by digitalization require a revision of the basic principles for ensuring the economic security of the state. Timely tracking of changes manifested in challenges is important to counter new threats. A detailed study of the world experience, in particular, of economically developed countries, in the formation of the digital economy made it possible to identify a number of challenges for which it is advisable to develop adequate response measures in order to avoid possible threats to the economic security of the state.
The Impact of Information Technology on Tourism Development Potential
Authors: Kudusova M. I. , Shemileva M. S-A. , Aliev I. M.
Published: July 2023

This article discusses the potential of tourism in regional development and its impact on various regions of the world. The paper presents an overview of the economic, social and environmental benefits of tourism and the problems that may arise in the development of tourism in the region.
The Crowdfunding Platforms Financing Models Analysis
Authors: Magomadova Madina , Aliyev Ayaz , Tursunov Bakhrom
Published: July 2023

The present article is devoted to crowdfunding, an innovative direction. Crowdfunding is a modern method of project financing securing that allows a large number of people (individual investors and startups) to attract money for financial, commercial, cultural and social projects online, often in exchange for future products and services. The purpose of this study is to discuss and present the potential of crowdfunding as an integral part of the investment infrastructure including the analysis of models providing crowdfunding platforms financing. This target is achieved through a systematic approach involving empirical research analysis, bibliometrics analysis and publication content analysis. The main theoretical constructions and conclusions are based on the evolutionary theory of crowdfunding platforms. The assumption of the study is that a crowdfunding approach can increase the innovative projects financial and commercial success. Crowdfunding is growing in the United States and has successfully become a new form of project funding. The authors describe the experience and the structure of business ideas and startups crowdfunding using the example of the Kickstarter, a technological platform for social innovation in the United States. The authors assert that this experience can not only be successfully transferred to Russia but can also become an effective mean of attracting foreign investors to the country’s economy. Authors consider the essence, forms, advantages, disadvantages and perspectives of crowdfunding in this context.
Using Management Accounting Information in an Audit
Authors: Yusupov R. M.
Published: July 2023

An external auditor, as well as the problems of such use of management accounting information in full devote this article to the possibility of using accounting and reporting data for management when evaluating the results of an organization’s activities. In this case, the auditor has the opportunity to use the management accounting information of the audited entity in full.