bluuebunny/crossref_metadata_2025 huggingface dataset:
Control de inventarios y su incidencia en la rentabilidad de la empresa Kapek Comsa S.A.C. La Victoria 2019
Authors:   , Ichpas Janampa Jesusa
Published: August 2023

Establecer la relación entre los controles de inventarios y la rentabilidad de la empresa Kapek Comsa S.A.C. ubicada en La Victoria, fue el principal objetivo del presente trabajo de investigación. El camino metodológico conllevó a un trabajo con enfoque cuantitativo, descriptivo y correlacional, donde se aplicó un cuestionario conformado por 27 preguntas con opciones de respuesta a catorce colaboradores de la empresa. Para examinar los datos recolectados se empleó la aplicación informática estadística SPSS Statistics 25. Los resultados reflejaron una asociación estadísticamente significativa que permitió relacionar el comportamiento de las variables analizadas; asimismo, a nivel descriptivo los porcentajes más altos permitieron concluir que la empresa lleva una adecuada gestión y control del inventario específico de acuerdo a sus necesidades, así como tomas de inventario de forma periódica y rotación en los almacenes, además de ser una empresa sostenible económicamente. Se recomienda dar continuidad a la gestión de control de inventario que se realiza en la empresa, así como evaluaciones para detectar nuevas necesidades que pudieran surgir en los almacenes de la empresa, con el fin de mantener los altos porcentajes en los controles y políticas de inventarios en la empresa y uso eficiente de activos, entre otros.
Asociación del perimetro abdominal y la presión arterial en personas de 20 a 69 años en el Perú entre el 2018-2020
Authors:   , Laveriano Terreros Ivett Jackeline
Published: August 2023

Objetivos: El objetivo del presente estudio fue evaluar si existe asociación entre la obesidad abdominal, medido con el parámetro de perímetro abdominal, e hipertensión arterial, y si esta asociación difiere por sexo y por niveles de índice de masa corporal (IMC) en Perú. Materiales y métodos:Estudio transversal con análisis secundario de la Encuesta Nacional Demográfica y Salud Familiar (ENDES) 2018, 2019 y 2020. Se incluyó a personas entre 20 a 69 años, residentes habituales de las viviendas seleccionadas. Las variables de interés fueron obesidad abdominal, basado en el perímetro abdominal e hipertensión arterial. Se crearon modelos de regresión para verificar la asociación y se estimaron las razones de prevalencias (RP) e intervalos de confianza al 95%. Resultados: Se analizaron los datos de 68 994 personas, media de edad 38,9 (DE:12,8), y 39 093 (56,7%) mujeres. La prevalencia de obesidad abdominal fue de 45,1% (IC 95%: 44,4% - 45,8%), siendo mayor en mujeres que en varones, mientras que la prevalencia de hipertensión arterial fue del 18,6% (IC 95%: 18,0% - 19,2%). En modelo multivariable, la obesidad abdominal estuvo asociada a mayor prevalencia de hipertensión arterial (RP= 1,26; IC 95%: 1,68 - 1,90), siendo dicha asociación mayor en mujeres (RP=1,39; IC 95%: 1,19 - 1,63) que en varones (PR=1,33; IC 95%: 1,18 - 1,50). De acuerdo con el IMC, la asociación fue mayor y significativa en los que tenían sobrepeso (PR=1,37; IC 95%: 1,22 - 1,53). Conclusiones: El presente estudio demuestra una asociación positiva entre el perímetro abdominal e hipertensión arterial, la cual fue ligeramente mayor en mujeres que en varones. Aquellos con sobrepeso de acuerdo con el índice de masa corporal presentaron una asociación positiva y significativa entre obesidad abdominal e hipertensión.
Asociación entre la presencia de anemia al finalizar el embarazo y la ganancia de peso excesiva en gestantes del Centro Médico Naval Cirujano Mayor Santiago Távara durante los años 2017-2021
Authors:   , Fernandez de Cordova Rosales Lucia , Montalvan Peñaranda Valeria Estefania
Published: August 2023

Objetivo: El objetivo de la investigación fue determinar la asociación entre la presencia de anemia al finalizar el embarazo y la ganancia de peso excesivo en gestantes del Centro Médico Naval “Cirujano Mayor Santiago Távara (CMST)” durante los años 2017-2021. Materiales y métodos: Se realizó un estudio de tipo observacional, transversal, retrospectivo en base al análisis de información disponible en historias clínicas y con un enfoque estadístico tipo analítico. El cálculo de la muestra fue de 172 historias clínicas de todas las primigestas que fueron atendidas en el Servicio de Ginecología y Obstetricia del Centro Médico Naval “CMST”; se tomaron los datos de la evaluación realizada entre las 37-42 semanas de gestación y sin complicación obstétrica en el periodo 2017-2021. Los datos fueron procesados en el programa Stata, utilizando la Prueba Exacta de Fisher, con un nivel de confianza del 95% y margen de error del 5% para identificar si existe asociación entre las variables estudiadas. Resultados: El 44,44% de las gestantes estuvieron comprendidas en el rango de 26-30 años. Asimismo, el 63,95% presentó normopeso, 29,65% sobrepeso y 3,49% obesidad. Con relación a la ganancia de peso gestacional el 50,58% de las gestantes presentó alta ganancia (entre 12-20 Kg) y el 40,7% adecuada ganancia de peso. El 63,37% tuvo hemoglobina normal, 32,56% presentó anemia leve y 4,07% anemia moderada. Conclusiones: No se encontró asociación significativa (p= 0,98) entre la ganancia excesiva de peso con el desarrollo anemia al finalizar el embarazo.
Study on urban Resilience Based on the Analysis of Supply Guarantee Facilities during Epidemic Closure -- a Case Study of Shanghai in 2022
Authors: Wang Jun , Wei Ran
Published: August 2023

In the case of major public emergencies, the ability of cities to resist shocks becomes very important and reflects urban resilience. This paper selects the supply guarantee facilities during the city-wide lockdown of Shanghai during March-May 2022 due to COVID-19 pandemic as the research object. In this research, the thermodynamic diagram map generated based on cell phone visits reflects the actual distribution of population, and the per capita supply guarantee capacity and supply guarantee overlay intensity are analyzed based on official list of facilities, and the actual role of the supply guarantee facilities are investigated through a public research questionnaire. Based on these analyses, the level of “supply guarantee resilience” was evaluated and graded for each district of Shanghai. It was concluded that the overall level of supply guarantee resilience was high in the central city, divergence in the near suburban districts, and generally low in the remote suburban districts. Based on this, the paper summarize the problems of supply guarantee revealed in Shanghai during the epidemic lockdown and propose strategies to improve the resilience of similar scenarios in the future. With the help of big data and public research tools, this paper aims to provide ways and methods to evaluate the resilience of cities under major public emergencies.
An experimental investigation of the thermal usability of outdoor environments for urban heat mitigation, adaptation, and governance
Authors: Huang Boze , Dong Xin , Tian Yu , Yin Mingqiang , Qiu Yufeifei , He Bao-Jie
Published: August 2023

This study develops a quantitative method to assess the thermal usability (e.g. rideability, walkability, entertainmentability, exercisability, and workability) of outdoor spaces. The benchmark for thermal usability was assessed by four widely-used indicators (Wet Bulb Temperature (WBGT), Predicted Mean Vote (PMV), Physiologically Equivalent Temperature (PET) and Universal Thermal Climate Index (UTCI)). Among these five dimensions of thermal usability, exercisability was the most significantly thermally-affected, as WBGT was greater than 30℃, exercisability dropped to below 50%, while the other four usability dropped to below 75%. An empirical study based on field experiments in Changzhou, China was performed. The results indicated that the quantitative method was capable of assessing the thermal usability of various urban spaces (e.g. basketball court, badminton field, walkway space and natural lawn), and could guide people in spatial modifications, outdoor activities and site management. The empirical studies also showed that airflow and radiation were the two critical meteorological factors, associated with urban infrastructure affecting the thermal usability of outdoor spaces. Activity metabolism showed a positive correlation with participant heat stress and a negative correlation with the thermal usability. Guidelines are used to guide participants to avoid optional activities and to provide them protective recommendations for necessary activities during periods of low thermal usability. Overall, this paper promotes methodological understandings of thermal usability, and provide policy makers, urban planners and designers, and urban managers with implications on effective heat solutions.
Physical vulnerability of reinforced concrete buildings under debris avalanche impact based on GF-discrepancy and DEM-FEM
Authors: Pu Jian , Huang Yu , Guo Zhen , Bi Yandong
Published: August 2023

Debris avalanches caused by landslides often lead to building damage, and insufficient research has been conducted on the vulnerability of buildings, especially reinforced concrete (RC) buildings, to such impact disasters. Here, a vulnerability assessment framework for a two-story RC building based on the generalized F-discrepancy (GF-discrepancy)-based point selection strategy and discrete element method (DEM)-finite element method (FEM) is proposed. Considering the randomness of granular flow, including the impact height, impact velocity, and density, these three random variables are uniformly selected using GF-discrepancy, for a total of 134 samples. A deterministic analysis of each sample is performed to obtain the responses of the 134 samples according to the DEM-FEM coupling method, which can fully reflect the failure characteristics of RC buildings under mass flow impact. Given the qualitative vulnerability assessment, we select the inter-story displacement angle and the displacement of walls and columns in the responses as quantitative indicators defining the four damage states and the vulnerability of the building. The former is used to evaluate the overall damage state of the building, while the latter is applied to evaluate the local damage situation of the building as a correction to the first indicator. Ultimately, the vulnerability of the building is obtained corresponding to different impact indictors related to three random variables. This method provides not only the vulnerability of RC buildings under particle flow impact but also insight into vulnerability assessments of buildings in areas that are not currently in danger of such disasters.
Usefulness of lordosis load test and urinary biochemistry in diagnosis of orthostatic proteinuria
Authors: Tasaki Yuko , Yamamiya Mari , Taniyama Yuichi , Kasahara Ria , Yachi Yusuke , Fukuda Masaki , Obata Misato , Inoue Mika , Sakazume Shinobu , Ohta Kazuhide
Published: August 2023

Introduction Renal disease is commonly suspected in patients with proteinuria. Renal biopsy might be considered based on the patient’s clinical history and the results of diagnostic tests. However, as orthostatic proteinuria is benign and requires no treatment, it is important to obtain a diagnosis without renal biopsy whenever possible. Therefore, up to now, for the diagnosis of orthostatic proteinuria, in addition to resting urinalysis evaluation (disappear of proteinuria), we have performed the lordosis load test and performed urine biochemistry of the samples showing peak proteinuria in lordosis load test.
Method We retrospectively enrolled all patients who visited the pediatric department and underwent the lordosis load test at Kanazawa Medical Center between 2011 and 2020. In the present study, samples with the highest concentrations of protein after the lordosis load test were subjected to general urinary biochemistry and urinary sediment analysis. Patients were followed up with the lordosis load test for several years.
Results General urinary tests, urinary sediment and urinary biochemistry including N-acetyl-beta-D-glucosaminidase (NAG), alpha1-microglobulin(α1MG), and beta 2-microglobulin (β2MG) were normal in all patients with orthostatic proteinuria except one case who was premature baby.
Conclusion If proteinuria disappears after 2 hours of rest, and urinary biochemistry of the samples showing peak proteinuria in lordosis load test is normal, orthostatic proteinuria can be diagnosed more accurately.
Acute phase protein concentration in pharyngeal swabs from clinically healthy commercial dairy calves
Authors: Petersen Mette Bisgaard , Capion Nynne
Published: August 2023

Background
Early diagnosis of disease in calves are crucial for fast recovery and prudent use of antibiotics. Acute phase proteins (APP) are up- or downregulated in response to tissue injury and have been studied widely in human medicine. There is growing interest to use APPs as biomarkers for different diseases and as a tool to initiate and monitor treatment in veterinary medicine too. Pharyngeal swabs, tracheal aspirate (TA) and blood samples were collected from 84 clinically healthy commercial dairy calves and analyzed for the APPs serum amyloid A (SAA), haptoglobin (Hp) and lipopolysaccharide binding protein (LBP).
Results
We found detectable concentrations of SAA, Hp and LBP in pharyngeal swabs from calves, as well as in TA and serum. We found no correlations between APP concentrations in serum and TA nor pharyngeal swabs.
Conclusions
SAA, Hp and LBP can be measured in saliva and TA from calves. However, a considerably technical variation in the sampling method for both pharyngeal swab and TA exist, and further validation of the methods are needed.
The Effects Of Habitat On The Distribution Of Urban Ruderal Vegetation
Authors: YALÇINALP Emrah , DİHKAN Asena , Meral Alperen , AKBULUT Sefa
Published: August 2023

Ruderal habitats consist mostly of neutrophile plants that grow on specific areas such as remnant areas, ruins, and wall sides. The plants hold an important place in urban ecology due to their resistance to environmental conditions and anthropogenic impacts. Considering the past 20-year period, today’s rural areas will soon become urban areas in most parts of the world. Thus, this study will contribute to the phytoecological and phytosociological studies that will elaborately examine urban ruderal habitats in near future. The study was carried out in 30 different locations in five different land use types in Trabzon, Turkey. It aims to determine the ruderal vegetation diversity and the effect of habitat on ruderal vegetation. The results of the study revealed 83 species across 33 families. Despite the species diversity of the samples from the roadsides differed from that of other regions, the ruderal vegetation was distributed homogeneously, leading to the conclusion that habitat did not affect vegetation.
Radiative Forcing Bias Calculation Based on COSMO (Core-Shell Mie model Optimization) and AERONET data
Authors: Tiwari Pravash , Cohen Jason , Wang Xinying , Wang Shuo , Qin Kai
Published: August 2023

Direct radiative forcing (DRF) of aerosols is driven by aerosol concentration, size, and mixing state, and solar radiation. This work introduces Core-Shell Mie model optimization(COSMO) to compute top of the atmosphere (TOA) forcing based on inversely constrained BC size and mixing state from AERONET, over two rapidly developing areas: Lumbini and Taihu. COSMO has wider variability and less negative TOA than AERONET (13.0 ± 8.1 Watt/m2 at Lumbini and 15.6 ± 12.4 Watt/m2 at Taihu). These differences are driven by particle aging and size-resolved BC emissions, with up to 17.9% of cases warmer than the maximum AERONET TOA, and 1.9% net-warming. A linearized correction is deduced which can be immediately implemented by climate models, and suggested ranges of BC size- and mixing- observations are made for future campaigns. Given that the COSMO TOA bias and uncertainty are larger than the forcing of locally emitted GHGs, active consideration of BC is necessary to reduce climate uncertainty in developing areas.
Identification of immune cells and key genes related to periodontitis
Authors: Sun Yingyuan , Wang Chunxiao
Published: August 2023

Background
The aim of this study was to identify the immune cellular and molecular mechanisms of periodontitis and the important role of key genes in the pathogenesis of periodontitis.
Methods
GSE16134, GSE10334, and GSE23586 were obtained from the Gene Expression Omnibus (GEO) database, and CIBERSORT was applied to examine the constitution of 22 kinds of immune cells in all samples. Weighted gene coexpression network analysis (WGCNA) was employed to identify candidate module genes associated with periodontitis. The least absolute shrinkage and selection operator (LASSO) and support vector machine (SVM) algorithms were constructed to screen key genes. The key genes-related signaling pathways were explored through gene set variation analysis (GSVA). Moreover, the R package "RcisTarget" was adopted to predict transcription elements, and Cytoscape software was used to visualize the miRNA network. Constructing a nomogram model on the basis of the key genes expression level for the diagnosis of periodontitis.
Results
There were 427 periodontitis samples and 136 healthy samples. Periodontitis samples’ CD4 memory resting T cells were significantly higher, and WGCNA demonstrated that genes in the black module had the highest correlation with CD4 memory resting T cells. Seven genes, including AHNAK2, ALOX12B, CBR3, FAM57A, KLK8, KRT3, and TGM5, were associated with T cells in periodontitis. The identified key genes showed a strong correlation between immune cell infiltration levels and immune factors, primarily participating in multiple signaling pathways, including but not limited to the ESTROGEN RESPONSE EARLY, MYC TARGETS V2, G2M CHECKPOINT, and PI3K AKT MTOR signaling pathways. 73 miRNAs and 163 mRNA‒miRNA relationship pairs were identified, which were subsequently visualized. We constructed a nomogram model on the basis of the expression levels of the seven genes for diagnostic value, and the area under the AUC curve of the nomogram model was 0.937.
Conclusions
Periodontitis-related immune cells and key genes were identified, and the important role of key genes in the pathogenesis of periodontitis was explored through a series of bioinformatics analyses.
China’s sustainable carbon neutral supply chain management: A reference to global emission reduction
Authors: Chen Yongxiu , Lee Chien-Chiang , Zhu Shanzhan
Published: August 2023

Carbon emissions dominate the main issues in the process of energy consumption, and numerous countries are committed to reducing such emissions with a focus on carbon neutrality. To narrow down the research gap, this research considers carbon emission reduction in industry by applying supply chain management (SCM) under monopolistic competition with carbon neutral indicators. We develop a mathematical model within an agent-based simulation model and perform the design experimental methods to achieve the optimal decision-making of supply chain carbon neutral indicators. Findings show that green-credit policies and preferences of green products are effective carbon neutral indicators in SCM that help reduce global carbon emissions. Our research not only offers a reference and inspiration for the China government to reduce carbon emissions, but also helps government decision-makers explore the optimum level and decision-making of green credit and preferences of green products in a supply chain environment. Lastly, it enables manufacturers to achieve profit maximization and move towards carbon neutrality.
Automatic segmentation model of primary central nervous system lymphoma based on multiple sequences of magnetic resonance images using deep learning
Authors: Lu Guang , Zhou Wei , Zhao Kai , Miao Lixin , Wang Wenjia , Wang Qingyu , Zhang Xuefen , Gong Yuping , Mou Weiwei
Published: August 2023

Purpose and Background. Accurate quantitative assessment of PCNSL by gadolinum-contrast Magnetic resonance imaging (MRI) is closely related to therapy planning, surveillance and prognosis, However, precise volume assessment by manual segmentation is time-consuming and subject to high intra- and interrater variabilities by imaging readers, with poor consistency. In order to solve this problem, we constructed a multimodal artificial intelligence deep learning segmentation model based on multi-sequence MRI images of patients with PCNSL and identified its efficiency, so as to quantitatively calculate volume and other indicators, and compare the consistency and accuracy with doctors' labeling methods.
Materials and Methods. A total of 41 PCNSL patients from six Chinese medical centers with pathologically confirmed PCNSL were analyzed. Region of interest (ROI) was manually segmented on contrast-enhanced T1-weighted and T2 scans. Fully automated voxelwise segmentation of tumor components was performed using a 3D convolutional neural network (DeepMedic) trained on gliomas (n = 220). deep-learning model (DLM) segmentations were compared to manual segmentations performed in a 3D voxelwise manner by two readers (radiologist and neurosurgeon; consensus reading) from T1 CE and FLAIR, which served as the reference standard. The Dice similarity coefficient (DSC) were used to evaluate the performance of the models. Successful detection of PCNSL was defined if the DLM obtained a spatial overlap with the manual segmentation of the tumor core (at least one voxel, DSC >0). Mann-Whitney U test was applied to compare continuous variables, while chi-squared test was used for categorical variables between groups. A two-tailed P value <0.05 indicated statistical significance.
Results. The DLM detected 66 of 69 PCNSL, representing a sensitivity of 95.7%. Compared to the reference standard, DLM achieved good spatial overlap for total tumor volume (TTV, union of tumor volume in T1 CE and FLAIR; average size 77.16 ± 62.4 cm3, median DSC: 0.76) and tumor core (contrast enhancing tumor in T1 CE; average size: 11.67 ± 13.88 cm3, median DSC: 0.73). High volumetric correlation between automated and manual segmentations was observed (TTV: r= 0.88, P < 0.0001; core: r = 0.86, P < 0.0001). Performance of automated segmentations was comparable between pre-treatment and follow-up scans without significant differences (TTV: P = 0.242, core: P = 0.177).
Conclusion. Compared to manual segmentation on routine clinical MRI images, our automatic segmentation model of PCNSL based on multiple sequences of MRI images displayed comparable segmentation in both pretherapy and the process of the treatment, despite the complex and multifaceted appearance of this lymphoma subtype , implying its immense potential to be used in the whole follow-up monitoring process of PCNSL.
Robotic Arm Trajectory Based on Machine Learning for tracking the wound
Authors: Simango Doubt , Mushiri Tawanda , Yahya Abid , Ndaimani Augustine
Published: August 2023

Due to uncontrolled bleeding in victims and frequently delayed emergency response times to road accidents had frequently causes severe casualties. To solve this problem, the robotic arm used in this paper, based on machine learning, is programmed to monitor and react to bleeding in accident victims. A clotting agent is applied to the wounds by the robotic arm at the touch of a button, stopping the bleeding and possibly saving lives. The system's image processing and wound classification were done in a Python-based Jupyter environment. SolidWorks was used to design the robotic arm, which was programmed to respond to input from a Python model. The robotic arm's kinematics was tested in the Simulink environment, displaying the joints' successful operation. The robotic arm design was further analyzed in the Simcape environment, where the arm's trajectory was evaluated. The results showed that the robotic arm could effectively move toward the detected wound, following the training trajectory. Object tracking was successfully performed in Matlab under the Simcape environment, as evidenced by the alignment between the expected and actual trajectory line graphs. The study concludes that the machine learning-based robotic arm can accurately move to any desired position within its workspace, enabling the precise application of the clotting agent on the wound. This system holds significant potential for improving emergency response times and outcomes in road accidents.
The Relationship of Pre-Pregnancy Body Mass Index with Maternal Anthropometric Indices, Weight Retention and the Baby's Weight and Nutrition in the First 6 Months Post-partum
Authors: Ahmadibeni Ayda , Kashani Parhoon , Hallaj Mohammad Sadegh , Ghanbari Saeed , Javadifar Nahid
Published: August 2023

Purpose:
Pre-pregnancy body fat mass is one of the important indicators of the mother's and the infant's health. Therefore, the purpose of this study was to investigate relationship of pre-pregnancy body mass index (PPBMI) with maternal anthropometric indices and weight retention as well as the baby's weight and nutrition in the first 6 months post-partum.
Materials and methods:
This is a prospective cohort study including 397 mothers giving birth to healthy babies and referring to health centers in Ahvaz (southwest of Iran) in 2022. The following data were extracted from the participants' electronic record: body mass index (BMI) before or at the beginning of pregnancy, gestational weight gain, and weight at the time of delivery. In addition to demographic information, the following data were also evaluated: maternal anthropometric indices including weight, hip and waist circumference, and conicity index during the first 10 days post-partum, along with the weight and nutrition pattern of the baby 2, 4 and 6 months post-partum.
Results:
The mean age of the mothers was 29.96 ± 5.7 years. The frequency of mothers according to BMI classification (i.e., underweight, normal, overweight, and obese) was 4.3%, 38.5%, 37%, and 20.3%, respectively. In this study, PPBMI had a significant relationship with weight, waist and hip circumference, conicity index, gestational weight gain, and maternal weight retention 2, 4 and 6 months post-partum. However, this relationship was not significant when it came to the weight of the baby at birth, and 2, 4 and 6 months post-partum (P < .05). According to the results of this study, the greatest amount of weight loss was observed in mothers with normal BMI, the greatest decrease in hip circumference was in obese mothers, and the greatest values of waist circumference and conicity index belonged to underweight mothers. Also, the highest frequency of mothers with excessive weight gain was in the obese mothers, while the highest values of post-partum weight retention (> 6 kg) were observed inunderweight mothers. The results of this study also showed that the highest frequency of low birth weight (LBW) was found in babies born to underweight mothers and the lowest frequency of breastfeeding until 6 months was observed in obese mothers.
Conclusion:
In this study, the greatest decrease in anthropometric indices such as weight, waist circumference, hip circumference, and conicity index was observed in obese mothers while the lowest decrease was experienced by overweight women. Also, the results of the present study re-emphasize the importance of focusing on provision of educational and counseling services to mothers in order to improve their nutrition and weight, especially before pregnancy.
Effect of shearing on production stability and die life in automatic multi-stage cold forging of an automobile wheel nut
Authors: Byun Jong Bok , Hamid Nurhidayah binti Abd , Cho Gyu Seob , Chung Wan Jin , Kang Sung Muk , Lee Kwang Hee , Joun Man Soo
Published: August 2023

In this study, the effects of earing in a sheared billet of S25C steel formed during rod shearing in an automatic multi-stage cold forging (AMSCF) process for an automobile wheel nut were experimentally and numerically investigated. Precision forging simulations with an emphasis on rod shearing were conducted using the implicit elastoplastic finite element method with a tetrahedral MINI-element scheme. AMSCF of an automobile wheel nut involves the use of a converging or near-conical die that shows a gradual reduction in its cross-sectional area. Our results showed that the shearing-induced earing plays the role of a pivot during balancing of the material inside the die cavity in the early stroke, before significant material contact. Earing formation resulted in a wobble motion of the material that accompanied the rigid-body motion. This ultimately led to a change in the center of mass of the material and unbalanced loading. Earing had a significant influence on the local high-cycle fatigue (HCF) fracture of die insets, especially in the cold forging of nut-like short products. The stress concentration on the die was attributed to asymmetric localized contact between the material and “critical die corner,” leading to changes in the mass center. Taken together, our results indicate that sheared billet characterization should account for earings with roll-overs and inclined surfaces to not only better predict the HCF life of die parts but also to optimize the forging outcome, particularly for safety products such as automobile wheel nuts.
A protocol for in vitro multiplication of Morella sp: a protected species in the Tambillo Community Protected Area - Ecuador
Authors: Murillo-Borrero Kevin , Corozo-Quiñónez Liliana , Durán Mateo David León , Ponce Fátima Macías , Pinoargote Miryan , Saltos-Rezabala Luis Alberto
Published: August 2023

The objective of this research was to develop a protocol for the in vitro establishment and multiplication of Morella sp. (Myricaceae). Tender apical shoots of Morella sp. were used as explants, which were disinfected under aseptic conditions with a 2% NaOCl solution for 4 minutes. Ninety percent of the apical shoots were free from contaminants. In the in vitro multiplication stage, the increase in the number of leaves was observed, being directly proportional to the concentration of the basal medium with WPM salts and vitamins + 0.25 mg.L-1 gibberellic acid (GA3) and different doses of 6-benzylaminopurine (BAP). The explants cultured in the basal medium with WPM salts and vitamins at 100% supplemented with 0.25 mg.L-1 GA3 + 1.5 mg.L-1 BAP, generating an average of 6.4 leaves per explant. Regarding in vitro rooting, no statistically significant differences (p > 0.05) were found in the number of roots per explant among the evaluated treatments of indole-3-butryic acid (IBA) and indole-3-acetic acid (IAA). However, the number and length of roots per explant were higher in the treatments supplemented with IBA, these showed the highest number of roots per explant (2.4 roots) at a dose of 0.75 mg.L-1 and a higher average length of 3.7 cm at a dose of 1 mg.L-1 IBA. The results obtained in this research lay the basis for further optimization of the micropropagation protocol for mass production of Morella sp. plants and to achieve the goal of reforesting Tambillo, the first community protected area in Ecuador.
Nitrate-responsive transcriptome analysis of the rice RGA1 mutant reveals G-protein α subunit regulation of nitrogen-sensitivity and -use efficiency
Authors: Prasanna Jangam Annie , Mandal Vikas Kumar , Kumar Dinesh , Chakraborty Navjyoti , Raghuram Nandula
Published: August 2023

Nitrogen (N) use efficiency (NUE) is important for sustainable agriculture. G-protein signalling was implicated in N-response/NUE in rice, but needs genetic characterization of the role of α subunit (RGA1). We found that RGA1 knock-out mutant in japonica rice exhibited lesser nitrate-dose sensitivity, higher yield and NUE relative to the wild type (WT). We investigated its genomewide basis using nitrate-responsive rga1 transcriptome relative to WT. It revealed 3,416 differentially expressed genes (DEGs), including 719 associated with development, grain yield and phenotypic traits for NUE. The upregulated DEGs were related to photosynthesis, chlorophyll, tetrapyrrole and porphyrin biosynthesis, while the downregulated DEGs belonged to cellular protein metabolism and transport, small GTPase signalling, cell redox homeostasis etc. RT-qPCR validated 26 nitrate-responsive DEGs across functional categories. Physiological validation of nitrate-response in the mutant and WT at 1.5 and 15 mM doses revealed higher chlorophyll and stomatal length but decreased stomatal density, conductance and transpiration. The consequent increase in photosynthesis and water use efficiency may contribute to higher yield and NUE in the mutant, whereas the WT was N-dose sensitive. The mutant was not as N dose-responsive as WT in shoot/root growth, productive tillers and heading date, but equally responsive as WT in total N and protein content. RGA1mutant is less impacted by higher N-dose or salt stress in terms of yield, protein content, photosynthetic performance, relative water content, water use efficiency and catalase activity. PPI-network analyses revealed known NUE-related proteins as RGA1 interactors. Therefore, RGA1 regulates N-dose sensitivity and NUE in rice.
Insight into synthesis and characterisation of Ga0.9Fe2.1O4 superparamagnetic NPs for biomedical applications
Authors: Mesaros Amalia , Garzón Alba , Nasui Mircea , Bortnic Rares , Vasile Bogdan , Vasile Otilia , Iordache Florin , Leostean Cristian , Ciontea Lelia , Ros Josep , Pana Ovidiu
Published: August 2023

A Ga3+-substituted spinel magnetite nanoparticles (NPs) with the formula Ga0.9Fe2.1O4 were synthesized using both the one-pot solvothermal decomposition method (TD) and the microwave-assisted heating method (MW). Stable colloidal solutions were obtained by using triethylene glycol, which served as a NPs stabilizer and as a reaction medium in both methods. A narrow size cridistribution of NPs, below 10 nm, was achieved through selected nucleation and growth. The composition, structure, morphology, and magnetic properties of the NPs were investigated using FTIR spectroscopy, thermal analysis (TA), X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and magnetic measurements. NPs with the expected spinel structure were obtained in the case of the TD method, while the MW method produced, additionally, an important amount of gallium suboxide. The NPs, especially those prepared by TD, have superparamagnetic behavior. In the case of MW preparation, the presence of a secondary phase affects both the dimensional distribution and the magnetic behavior of NPs. The NPs were tested in vitro on amniotic mesenchymal stem cells. It was shown that the cellular metabolism is active in the presence of Ga0.9Fe2.1O4 NPs and also preserves an active biocompatible cytoskeleton.
Genome-wide identification of WRKY gene family and expression analysis under abiotic stresses in Avena sativa
Authors: Ren Guoling , Li Mingjing , Han Zihui , Zhou Jiahui , Yin Yajie , Chen Naiyu , Ling Lei
Published: August 2023

The WRKY gene family plays a vital role in plant growth and development and abiotic stress response. This will provide reference for further study on the regulation mechanism of WRKY gene family in response to abiotic stress in A.sativa. In this study, We identified 165 WRKY family members by bioinformatics methods. Furthermore, the chromosomal localization, phylogenesis, conserved motifs, gene structure and gene replication were analyzed for WRKY genes. There are many response elements related to abiotic stress in AsWRKY member promoter region. qRT-PCR experimental results showed that WRKY gene played a regulatory role in cold stress, low temperature, salt stress and salt-alkali stress. This study provided theoretical basis for further exploring the biological functions of WRKY gene family members in A.sativa.
Neck stiffness and bone osteolytic lesion in infants: a case report
Authors: Carraro Carolina , Rabusin Marco , Murru Flora Maria , Ammar Lydie , Barbi Egidio , Amaddeo Alessandro , Cozzi Giorgio
Published: August 2023

Background Neuroblastoma is the most frequent extracranial solid tumor occurring in childhood, representing approximately 28% of all cancers diagnosed in infants. Signs and symptoms of neuroblastoma vary with the site of development of the tumor and can mimic other diseases due to its extreme clinical variability. However, torticollis is not reported in the medical literature as a leading symptom of neuroblastoma.
Case presentation Here we report the case of a 3 years-old girl with fever and neck stiffness. Blood tests revealed a mild anemia and a rise in inflammatory markers. CT-scan showed a solid, heterogeneous, predominantly hypodense surrenal mass with eccentric calcification and extensive inhomogeneity of the vertebral metamers. A course of chemotherapy for neuroblastoma was promptly started with immediate clinical improvement.
Conclusions This case shows that the presence of torticollis could be a chief complaint of neuroblastoma. To our knowledge, neuroblastoma is not mentioned among life-threatening underlying conditions of torticollis in most recent literature reviews.
This case advises general practitioners that in presence of unexplained torticollis in a toddler a neuroblastoma should be ruled out.
Viral Communities in Millipede Guts: Insights into Diversity and the Potential Role in Modulating the Microbiome
Authors: Nweze Julius Eyiuche , Schweichhart Johannes Sergej , Angel Roey
Published: August 2023

Millipedes are important detritivores harbouring a diverse microbiome. Previous research focused on the microbiome, while the virome remains neglected. We elucidated the viral diversity in the hindguts of two millipede model species with distinct microbiomes: the tropical Epibolus pulchripes and the temperate Glomeris connexa. Based on metagenomic and metatranscriptomic assembled viral genomes (MAVGs), the viral communities differed markedly and preferentially infected the most abundant prokaryotic taxa. The majority of DNA viruses were Caudoviricetes (dsDNA), Cirlivirales (ssDNA), and Microviridae (ssDNA), while RNA viruses consisted of Leviviricetes (ssRNA), Potyviridae (ssRNA) and Eukaryotic viruses. A high abundance of subtypes I-C, I-B and II-C CRISPR-Cas systems was found, primarily from Pseudomonadota, Bacteroidota and Bacillota. In addition, auxiliary metabolic genes (AMGs) that modulate chitin degradation, vitamins and amino acid biosynthesis, and sulfur metabolism were also detected. Lastly, we found low virus-to-microbe-ratios (mVMR) and a prevalence of lysogenic viruses, supporting a Piggyback-the-Winner dynamic in both hosts.
Computing all persistent subspaces of a reaction-diffusion system
Authors: Peter Stephan , Woitke Linus , Dittrich Peter , Ibrahim Bashar
Published: August 2023

An algorithm is presented for computing for a reaction-diffusion partial differential equation (PDE) system all possible subspaces that can hold a persistent solution of the equation. For this, all possible sub-networks of the underlying reaction network that are distributed organizations (DOs) are identified, because recently it has been shown that a persistent subspace must be a DO. The algorithm computes the hierarchy of DOs starting from the largest by a linear programming (LP) approach using integer cuts. The underlying constraints use elementary reaction closures (ERCs) as minimal building blocks to guarantee local closedness and global self-maintenance, required for a DO. Additionally, the algorithm delivers for each subspace an affiliated set of organizational reactions (SOR) and a minimal compartmentalization that is necessary for this subspace to persist. It is proved that all SORs of a reaction network, as already DOs, form a lattice and that this lattice contains all potentially persistent sets of reactions of all constrained solutions of reaction-diffusion PDEs. This provides a hierarchical structure of all persistent subspaces with regard to the species and also to the reactions of the reaction-diffusion PDE system. Here, the algorithm is described and corresponding python source code is provided. Furthermore, an analysis of its run time is performed and all models from the BioModels database as well as further examples are examined. Apart from the practical implications of the algorithm the results also give insights into the complexity of solving reaction-diffusion PDEs.
Comparative Investigation of The Effects of Conventional and Skeletal Anchorage Supported Pendulum Appliances on Dentofacial Structures
Authors: Aksoy Ayca , Ozen Oyku , Erdem Murat Kaan , Erdem Dilek
Published: August 2023

Objective: The aim of this study is to compare the effects of the conventional pendulum and pendulum appliances applied with miniscrew to eliminate the anchorage loss on skeletal and dentoalveolar structures.
Materials and Methods: Research groups consist of 30 individuals with skeletal class 1, dental class II malocclusion. The patients included into 3 groups. Group 1 who treated with conventional pendulum appliance; Group 2 who are applied pendulum with single miniscrew; Group 3 who are applied pendulum with double miniscrews. Pendulum appliances were completed when Class I molar relationship was obtained and data were analysed.
Results: Distalization applications was statistically significantly shorter in Group 3. Distal tipping was observed in all groups. In incisor teeth, protrusion was observed in both groups except the Group 3. The increase in the overjet was found to be statistically significantly lower in Group 3. Changes in SNA values were not statistically significant, the decrease in the SNB value was insignificant in Group 1, while a statistically significant decrease was observed in the groups using skeletal anchorage.
Conclusion: Ideal molar relationship has been achieved in all pendulum appliances without patient cooperation. Side effects were seen less in pendulum which skeletal anchoring was provided with double miniscrew support and treatment time in this was shortened.
Clinical Relevance: Pendulum appliances have specific uses in orthodontics. When these appliances are used in the proper indication, they shorten the treatment time and increase patient motivation. Clinicians using pendulum should be know their clinical indications, the potential problems and benefits.
Prevalent Landscape of Tumor Genomic Alterations of Luminal B1 Breast Cancers Using a Comprehensive Genomic Profiling Assay in Taiwan
Authors: Chen Bo-Fang , Tsai Yi-Fang , Lien Pei-Ju , Lin Yen-Shu , Feng Chin-Jung , Chen Yen-Jen , Cheng Han-Fang , Liu Chun-Yu , Chao Ta-Chung , Tseng Ling-Ming , Huang Chi-Cheng
Published: August 2023

Background:
The human epidermal growth factor receptor 2 (HER2) negative luminal B1 subtype of breast cancer has been reported with a poorer outcome than luminal A in recent studies. This study aimed to investigate the molecular alterations and identify potential therapeutic targets by analyzing the genetic profiling from a cohort of luminal B1 breast cancer in Taiwan.
Methods:
We enrolled patients with luminal B1 breast cancer in our study. They were classified as patients who received curative surgery and adjuvant or neoadjuvant chemotherapy as the low-risk group, and who had advanced or metastatic disease or early relapse during the follow-up time as the high-risk group. Using targeted sequencing, we evaluated genomic alterations, interpreting variants with the ESMO Scale of clinical actionability of molecular targets (ESCAT).
Results:
A total of 305 lumina B1 breast cancer patients underwent targeted sequencing analyses. The high-risk patients reported more actionable genes and called variants than the low-risk group (P < 0.05). PIK3CA (42%), FGFR1 (25%) and BRCA1/2 (10.5%) were the most prevalent ESCAT actionable alterations in luminal B1 breast cancer. There was no difference in the prevalence of actionable mutations between these two groups, except for ERBB2 oncogenic mutations, which were more prevalent among the high-risk than the low-risk group (P < 0.05). Alterations in PTEN, ERBB2 and BRCA1/2 were associated with disease relapse events in luminal B1 breast cancer.
Conclusions:
PIK3CA, FGFR1 and BRCA1/2 were the most prevalent actionable alterations among Taiwanese luminal B1 breast cancer. Moreover, PTEN and BRCA1/2 was significantly associated with disease relapse.
Wet activation and electrochemical performance of the residual carbon from coal gasification fine slag
Authors: Han Baobao , Zhu Jiaqi , Liu Rui , Xin Guoxiang , Wang Yao , Gao Jianmin , Song Jinling
Published: August 2023

It is difficult to utilize the large amount of gasification slag produced in the coal chemical industry, which is a major problem in solid waste resource utilization. The residual carbon from coal gasification fine slag (RC) was actived by KOH wet method. The activation temperature (110℃, 130℃, 150℃, 170℃) was tuned to regulate the pore structure of the RC and explore the effects on the electrochemical performance. When the active temperature was 150℃, the electrochemical performance of the as-actived RC-150 exhibited the best among the actived materials. The specific capacitance of RC-150 reached 109.0 F/g at a current density of 0.5 A/g. The energy density of the symmetric supercapacitor using RC-150 as active materials reached 3.78 Wh/Kg at a current density of 2 A/g. After 10 000 cycles, the capacitance was able to maintain 103.81% of the initial value, showing better cycle stability. The results could be attributed to the improvement of pore structure, the removal of oxide impurities and the modulation of graphitization degree during the activation process.
Tribological and Mechanical laboratory Analysis of DLC as substitutes for hard chromium coating in view of Cold Rolling of High Carbon Steel Strips
Authors: Ould Choumad , Gachon Yves , Badiche Xavier , Montmitonnet Pierre
Published: August 2023

Two types of wear-resistant, heavy-duty rolls are widely used in high carbon steel strips cold rolling: High Speed Steel (HSS) rolls and chromium-electroplated rolls. Lower costs and replacement of chromium, criticized because of its effects on health, are two reasons to look for another coating solution for rolling mill rolls. To be economically viable, it must maintain surface quality in accordance with customer requirements, and / or allow larger strip reduction per pass, and / or work at higher rolling speed and / or resist wear better so as to roll more coils between roll changes. Different phenomena, strongly related to the nature of roll surface, must be controlled in order to benefit from such improvements: severe adhesive wear of strip and adhesive transfer (“pick up”, “roll coating”), abrasive wear of rolls. DLC coatings are widely used in various tribological applications. Their resistance to wear and adhesion gives them a high potential in rolling. The interest of a hydrogenated DLC coating (here, with 20 at.% H) has therefore been studied for this application. The proposed paper analyzes its tribological and mechanical characteristics under conditions relevant to rolling processes, using two well adapted tests. Its resistance to transfer, severe adhesive wear, abrasive wear and fatigue is evaluated and compared with reference materials used in the rolling industry, uncoated and chrome-coated HSS, but also with other PVD coatings (TiN, CrN, TiBN) already described in previous papers. The results show the good potential of this coating in this application.