bluuebunny/crossref_metadata_2025 huggingface dataset:
Discussion of the classification of pediatric drug clinical trials in children's hospitals in China
Authors: Yang Yong , Jiang Rui , Bai Gengliang , Liu Qingqing , Chen Yongfa
Published: July 2024

Objectives

This study aimed to gain insights into pediatric clinical trials conducted in children's hospitals in China and provide valuable references for the development of children's hospitals and the research and development of pediatric drugs.

Methods

A comprehensive search was performed on the Chinese Clinical Trial Registry (Chi CTR) and ChinaDrugTrials.org.cn to collect information on all clinical trials involving subjects under 18 years, including those conducted in children's hospitals. The retrieval period was extended until 31 December 2022.

Results

A total of 459 pediatric clinical trials were collected, comprising 299 from Chi CTR and 160 from the Drug Clinical Trial Registration and Information Publicity Platform (Information Platform). Post-marketing drug studies and phase III clinical trials accounted for the majority of research stages. These trials covered a wide range of diseases/systems, with a particular focus on respiratory system disorders, tumors, endocrine disorders, and nutritional or metabolic diseases. Chemical drugs constituted the most extensively studied category, while traditional Chinese medicine/natural drugs received comparatively less attention. Clinical trial activities were primarily geographically focused on the eastern coastal regions of China, with multicenter trials being the most predominant. Ethics committee approval was obtained for 427 studies.

Conclusion

The pediatric clinical trials conducted by children's hospitals in China have shown an overall upward trend; however, there is limited research focusing on traditional Chinese medicine, along with significant regional and institutional imbalances. Furthermore, there is still room for improvement regarding ethical review processes. It is recommended that children's hospitals enhance their scientific research capabilities while optimizing resource allocation to meet medical service demands effectively. Additionally, fostering more research-focused children's hospitals will contribute to the high-quality development of children's health in China.
Improving well-being and enhancing awareness in patients undergoing hemodialysis through the person-centered IARA model: an exploratory study
Authors: Di Marco Sara , Padovan Anna M. , Conti Novella , Aimasso Francesca , Viazzi Francesca , Fontana Vincenzo , Campanella Dalila , Kuvačić Goran , De Giorgio Andrea
Published: July 2024

Chronic kidney disease (CKD) globally represents a significant health challenge, particularly among patients undergoing chronic hemodialysis. A careful nutritional and pharmacological prescription plays a key role in the effective management of these patients to optimize serum electrolytes, such as potassium, phosphorus, and protein intake. Furthermore, these patients can suffer psychological distress due to dietary restrictions and tight medication schedules. The present study explores the effectiveness of the person-centered IARA model in improving physiological markers and quality of life in CKD patients undergoing hemodialysis treatment. To demonstrate the effectiveness of the IARA model, 60 patients (M = 40; F = 20; 60.5 ± 9.9 years) undergoing thrice-weekly hemodialysis sessions were enrolled and randomly and blindly assigned to the Control or IARA group. The reduction in abnormal blood potassium, phosphorus, and total protein levels was investigated, alongside the psychological state through the SF-12 questionnaire. Preliminary findings showed a discernible reduction in the frequency of abnormal blood K (> 5.0 mmol/L) and P (> 4.5 mmol/L) levels in the IARA group compared to the Control group. In particular, such reductions were approximately 40% for K (OR = 0.57; 95% CL = 0.23/1.46) and about 15% for P (OR = 0.86; 95% CL = 0.27/2.74). A similar tendency was also observed for patient fluid intake during each hemodialysis session, with the frequency of higher-risk patients in the IARA group being 50% lower (OR = 0.50; 95% CL = 0.07/3.79) than that of the Control group. Although preliminary findings from this study suggest that the IARA model may have a positive effect on CKD patients’ subjective wellbeing and quality of life (QoL), further research is needed to understand the long-term impact of the IARA intervention.
Termite mound soil based potting media: a better approach towards sustainable agriculture
Authors: Kathbaruah Shiney , Bhattacharyya Badal , Borkataki Shimantini , Gogoi Bhabesh , Hatibarua Preeti , Gogoi Sailen , Bhairavi K. Sindhura , Dutta Pranab
Published: July 2024

Termite mound soils are known to possess unique physico-chemical and biochemical properties, making them highly fertile. Considering their rich nutrient content, the objective of the current experiment is to assess the physico-chemical properties and enzyme activities of termite mound based potting media and evaluate theirperformance for further exploration in floriculture. Potting media consisting of termite mound soil (TS) of a subterranean termite, Odontotermes obesus were prepared in 7 different combinations with garden soil (GS), sand (S) and farmyard manure (FYM) and a control (without termite mound soil), i.e., T1 (TS, GS, S, FYM (v:v:v:v /1:2:1:1)), T2 (TS, GS, S, FYM (v:v:v:v / 2:1:1:1)), T3 (TS, S, FYM (v:v:v / 2:1:1)), T4 (TS, GS, FYM (v:v:v / 2:1:1)), T5 (TS, GS, S (v:v:v / 2:1:1)), T6 (TS, S, FYM (v:v:v / 3:1:1)), T7 (TS, S, FYM (v:v:v / 1:1:2)) and control (GS, S, FYM (v:v:v / 2:1:1)). The samples were then analysed in laboratory. Experimental analysis on physico-chemical and biological parameters revealed superiority of T7 (TS, S, FYM (v:v:v / 1:1:2)) in terms of pH (7.15), organic carbon (2.13%), available nitrogen (526.02 kg ha−1), available phosphorus (56.60 kg ha−1), available potassium (708.19 kg ha−1), dehydrogenase activity (18.21 μg TTF g−1 soil day−1), Phosphomonoesterase (PME) activity (46.68 54 μg p-nitrophenol/gsoil/h) and urease activity (3.39 μg NH4-N g−1 soil h−1). Whereas T4 (TS, GS, FYM (v:v:v /2:1:1)) registered superiority in terms of PME activity (50.54 μg p-nitrophenol/gsoil/h), Fluorescein diacetate (FDA) activity (11.01 μgfluorescein/gsoil/h) and Soil Microbial Biomass Carbon (SMBC) (262.25 μg/g). Subsequent to the laboratory analysis, two best potting mixtures (T7 & T4) were selected and their performance was assessed by growing a test crop, Tagetes erecta cv. Inca Orange. Considering the growth parameters, the potting media: T7 was found to be significantly superior in terms of plant spread (39.64 cm), leaf area index (4.07), fresh weight (37.72 g), yield (317.81 g/plant), and diameter (9.38 cm) of flower over T4 & control. The Benefit:Cost (B:C) ratio meaning the ratio of net returns to total cost of cultivation was determined. The B:C ratio of raising marigold flower as potted plant in T7 was 1.10 whereas the B:C ratio of the potting mixture of T7 was 2.52. This shows that T7 potting media is also economically viable choice for commercial purposes.
ITPR1 variant-induced autosomal dominant hereditary spastic paraplegia in a Chinese family
Authors: Li Rui , Liu Xuan , Ke Chenming , Zeng Fanli , Zeng Qingyi , Xu Xiaowei , Fan Xiaoqin , Zhang Ying , Hou Qinghua
Published: July 2024

Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disease prominently characterized by slowly progressive lower limb weakness and spasticity. The significant genotypic and phenotypic heterogeneity of this disease makes its accurate diagnosis challenging. In this study, we identified the NM_001168272: c.2714A > G (chr3.hg19: g.4716912A > G, N905S) variant in the ITPR1 gene in a three-generation Chinese family with multiple individuals affected by HSP, which we believed to be associated with HSP pathogenesis. To confirm, we performed whole exome sequencing, copy number variant assays, dynamic mutation analysis of the entire family, and protein structure prediction. The variant identified in this study was in the coupling domain, and this is the first corroborated report assigning ITPR1 variants to HSP. These findings expand the clinical and genetic spectrum of HSP and provide important data for its genetic analysis and diagnosis.
Excessive daytime sleepiness in myotonic dystrophy: a narrative review
Authors: Hoxhaj Domeniko , Pascazio Alessia , Maestri Michelangelo , Ricci Giulia , Fabbrini Monica , Torresi Francesca Buracchi , Siciliano Gabriele , Bonanni Enrica
Published: July 2024

Introduction

Excessive daytime sleepiness (EDS) is a common and debilitating symptom in both forms of myotonic dystrophy (DM), significantly impacting patients’ quality of life. The review focuses on the purpose of examining the current understanding of EDS in these conditions, the difficulty in correctly accessing it, the recent findings related to its etiology and prevalence, and a summary of potential therapeutic implications.

Methods

We conducted a comprehensive search through PubMed, selecting studies that provided significant insights into the mechanisms, prevalence, and management of EDS in DM1 and DM2.

Results and discussion

EDS is highly prevalent in both DM1 and DM2. Polysomnographic studies have revealed prominent dysregulation of REM sleep in DM1, suggesting a possible narcoleptic-like phenotype and alterations in NREM sleep that contributes to daytime sleepiness. Other factors have been proposed to explain EDS in DM1, including dysregulation of the sleep-wake circadian rhythm through nocturnal actigraphy analysis. The central origin of EDS is increasingly delineated supported by serotonin and orexin pathways dysfunction, and recent neuroradiological findings showing that in DM1 hippocampus volume was positively correlated with self-reported fatigue and somnolence. Sleep-disordered breathing and respiratory dysfunctions are prevalent in DM, their direct correlation with EDS remains complex and inconclusive, but respiratory evaluation should be recommended if obstructive sleep apneas or respiratory muscle dysfunctions are suspected. Drug interventions, such as modafinil and mexiletine, have shown promise in managing excessive daytime sleepiness and reducing myotonia without significant cardiac conduction effects. Enhancing EDS management in myotonic dystrophy is key to improving overall patient well-being.
Simulating tDCS electrode placement to stimulate both M1 and SMA enhances motor performance and modulates cortical excitability depending on current flow direction
Authors: Sato Takatsugu , Katagiri Natsuki , Suganuma Saki , Laakso Ilkka , Tanabe Shigeo , Osu Rieko , Tanaka Satoshi , Yamaguchi Tomofumi
Published: July 2024

Introduction

The conventional method of placing transcranial direct current stimulation (tDCS) electrodes is just above the target brain area. However, this strategy for electrode placement often fails to improve motor function and modulate cortical excitability. We investigated the effects of optimized electrode placement to induce maximum electrical fields in the leg regions of both M1 and SMA, estimated by electric field simulations in the T1and T2-weighted MRI-based anatomical models, on motor performance and cortical excitability in healthy individuals.

Methods

A total of 36 healthy volunteers participated in this randomized, triple-blind, sham-controlled experiment. They were stratified by sex and were randomly assigned to one of three groups according to the stimulation paradigm, including tDCS with (1) anodal and cathodal electrodes positioned over FCz and POz, respectively, (A-P tDCS), (2) anodal and cathodal electrodes positioned over POz and FCz, respectively, (P-A tDCS), and (3) sham tDCS. The sit-to-stand training following tDCS (2 mA, 10 min) was conducted every 3 or 4 days over 3 weeks (5 sessions total).

Results

Compared to sham tDCS, A-P tDCS led to significant increases in the number of sit-to-stands after 3 weeks training, whereas P-A tDCS significantly increased knee flexor peak torques after 3 weeks training, and decreased short-interval intracortical inhibition (SICI) immediately after the first session of training and maintained it post-training.

Discussion

These results suggest that optimized electrode placement of the maximal EF estimated by electric field simulation enhances motor performance and modulates cortical excitability depending on the direction of current flow.
Unfavorable food consumption in children up to school entry age: results from the nationwide German KiESEL study
Authors: Spiegler Clarissa , Jansen Sara , Burgard Leonie , Wittig Friederike , Brettschneider Anna-Kristin , Schlune Andrea , Heuer Thorsten , Straßburg Andrea , Roser Silvia , Storcksdieck Genannt Bonsmann Stefan , Ensenauer Regina
Published: July 2024

Introduction

Evidence points toward the early life being crucial for preventing nutrition-related diseases. As promotion of healthier food preferences in toddlerhood and preschool age might still modulate the trajectories of disease risk, understanding diet in these age groups is necessary. The objective was to analyze food consumption and diet quality of 1–5-year-old children living in Germany in relation to age and sex.

Methods

Data from 890 children, a subsample of the representative, cross-sectional Children’s Nutrition Survey to Record Food Consumption (KiESEL) conducted by the German Federal Institute for Risk Assessment in 2014–2017, were analyzed. Dietary data were collected using food records (3 consecutive plus 1 independent day). Diet quality was evaluated against the German food-based dietary guidelines (FBDG).

Results

Consumption of unfavorable foods (e.g., sweets, soft drinks) exceeded the recommended maximum of 10% of energy intake (E%) by a multiple in all age and sex groups (medians: 24.8–35.8 E%). Preschoolers consumed more unfavorable foods than toddlers and boys more than girls. More than half of the children exceeded the recommendation for meat intake (medians: 2.3–3.2% of the total food consumption (%TFC) vs. 2 %TFC), especially preschoolers. In nearly all children, vegetable consumption was too low (medians: 4.2–4.5 %TFC vs. 12 %TFC). Also, milk/milk product consumption was below recommendations, more so in preschoolers (median: 12.0 %TFC ♂, 11.9 %TFC ♀ vs. 18 %TFC) than in toddlers (median: 16.1 %TFC ♂, 19.6 %TFC ♀). In toddlers and preschoolers with overweight or obesity, adherence to dietary recommendations of these food groups was largely similar to that of the total sample. Overall, 5-year-olds showed an unhealthier dietary pattern than 1-year-olds, which already emerged at age 2 years and became more evident at age 3 years.

Discussion

An adverse dietary pattern arises and even deteriorates at a very young age, showing sex-specific aspects. High attention from public health and research needs to be given to toddlerhood and even earlier life phases, e.g., to develop more age-specific FBDGs, aiming at reducing unhealthy food consumption.
Correlation between fasting blood glucose level and risk of breast cancer in women: a single-center, prospective cohort study
Authors: Li Gefei , Yin Mingjie , Fan Zhimin , Qu Fengjiang
Published: July 2024

Purpose

We prospectively analyzed the correlation between fasting plasma glucose (FPG) and the risk of breast cancer in women; explored the independent risk factors for breast cancer in women, and compared the effect of FPG level on the risk of young and non-young breast cancer. Our study provides new evidence and ideas for research into breast cancer etiology in China, improves the accuracy of secondary prevention of breast cancer, and provides options for the clinical diagnosis and treatment of breast cancer patients with diabetes.

Materials and methods

Three cohorts of women participating in the first health examination of the Kailuan Group in 2006, 2008 and 2010 were assembled to conduct a descriptive analysis of the baseline data on FPG. The cumulative incidence of breast cancer in different groups over 13 years was calculated using the Kaplan-Meier method and groups were compared using the log-rank test. A Cox proportional hazards regression model was used to analyze the association between FPG level and the risk of breast cancer.

Results

The cumulative incidence of breast cancer increased in people with FPG higher than 5.29 mmol/L, but there was no significant difference in the effect of different levels of FPG on the risk of young breast cancer in the population. Different degrees of fasting glucose can affect the risk of non-young breast cancer in the population.

Conclusion

The results of this study suggest that the risk of breast cancer can be reversed by early intervention to control levels of FPG. Regular monitoring of FPG may reduce the misdiagnosis rate of breast cancer in the population.
Exploring treatment decision-making in chronic myeloid leukemia in chronic phase
Authors: Andorsky David , Kota Vamsi , Sweet Kendra
Published: July 2024

The introduction of tyrosine kinase inhibitors (TKIs) has transformed the treatment of chronic myeloid leukemia (CML). Each approved TKI has its own risk-benefit profile, and patients have choices across lines of therapy. Identifying the initial and subsequent treatment that will lead to the best possible outcome for individual patients is challenging. In this review, we summarize data for each approved TKI across lines of therapy in patients with CML in chronic phase, highlighting elements of each agent’s safety and efficacy profile that may impact patient selection, and provide insights into individualized treatment sequencing decision-making aimed at optimizing patient outcomes.
Pancreatic ductal adenocarcinoma: the latest on diagnosis, molecular profiling, and systemic treatments
Authors: Bugazia Doaa , Al-Najjar Ebtesam , Esmail Abdullah , Abdelrahim Saifudeen , Abboud Karen , Abdelrahim Adham , Umoru Godsfavour , Rayyan Hashem A. , Abudayyeh Ala , Al Moustafa Ala-Eddin , Abdelrahim Maen
Published: July 2024

Pancreatic ductal adenocarcinoma (PDAC) is currently the fourth leading cause of death in the United States and is expected to be ranked second in the next 10 years due to poor prognosis and a rising incidence. Distant metastatic PDAC is associated with the worst prognosis among the different phases of PDAC. The diagnostic options for PDAC are convenient and available for staging, tumor response evaluation, and management of resectable or borderline resectable PDAC. However, imaging is crucial in PDAC diagnosis, monitoring, resectability appraisal, and response evaluation. The advancement of medical technologies is evolving, hence the use of imaging in PDAC treatment options has grown as well as the utilization of ctDNA as a tumor marker. Treatment options for metastatic PDAC are minimal with the primary goal of therapy limited to symptom relief or palliation, especially in patients with low functional capacity at the point of diagnosis. Molecular profiling has shown promising potential solutions that would push the treatment boundaries for patients with PDAC. In this review, we will discuss the latest updates from evidence-based guidelines regarding diagnosis, therapy response evaluation, prognosis, and surveillance, as well as illustrating novel therapies that have been recently investigated for PDAC, in addition to discussing the molecular profiling advances in PDAC.
Non-small cell lung cancer cells and concomitant cancer therapy induce a resistance-promoting phenotype of tumor-associated mesenchymal stem cells
Authors: Sentek Hanna , Braun Annika , Budeus Bettina , Klein Diana
Published: July 2024

Introduction

The tumor microenvironment gained attraction over the last decades as stromal cells significantly impact on tumor development, progression and metastasis, and immune evasion as well as on cancer therapy resistance. We previously reported that lung-resident mesenchymal stem cells (MSCs) were mobilized and activated in non-small cell lung cancer (NSCLC) progression and could even mediate radiation resistance in co-cultured NSCLC cells.

Methods

We investigated how MSCs were affected by NSCLC cells in combination with cancer (radiation) therapy in indirect co-cultures using tumor-conditioned medium and Transwells or direct three-dimensional NSCLC–MSC spheroid co-cultures in order to unravel the resistance-mediating action of tumor-associated MSCs.

Results

Although no obvious phenotypic and functional alterations in MSCs following NSCLC co-culture could be observed, MSC senescence was induced following co-applied radiotherapy (RT). Global gene expression profiling, in combination with gene set enrichment analysis upon treatment, was used to confirm the senescent phenotype of irradiated MSC and to reveal relevant senescence-associated secretory phenotype (SASP) factors that could meditate NSCLC RT resistance. We identified senescent tumor-associated MSC-derived serine proteinase inhibitor (serpin) E1/PAI1 as potential SASP factor mediating NSCLC progression and RT resistance.

Discussion

Specified intra-tumor–stroma interactions and cell type-specific pro-tumorigenic functions could not only improve lung cancer classification but could even be used for a more precise profiling of individual patients, finally paving an additional way for the discovery of potential drug targets for NSCLC patients.
A high reticulocyte count is a risk factor for the onset of metabolic dysfunction-associated steatotic liver disease: Cross-sectional and prospective studies of data of 310,091 individuals from the UK Biobank
Authors: Ma Peng-Cheng , Li Qi-Mei , Li Rui-Ning , Hong Chang , Cui Hao , Zhang Zi-Yong , Li Yan , Xiao Lu-Shan , Zhu Hong , Zeng Lin , Xu Jun , Lai Wei-Nan , Liu Li
Published: July 2024

Background and Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) poses a considerable health risk. Nevertheless, its risk factors are not thoroughly comprehended, and the association between the reticulocyte count and MASLD remains uncertain. This study aimed to explore the relationship between reticulocyte count and MASLD.

Methods: A total of 310,091 individuals from the UK Biobank were included in this cross-sectional study, and 7,316 individuals were included in this prospective study. The cross-sectional analysis categorized reticulocyte count into quartiles, considering the sample distribution. Logistic regression models examined the connection between reticulocyte count and MASLD. In the prospective analysis, Cox analysis was utilized to investigate the association.

Results: Our study findings indicate a significant association between higher reticulocyte count and an elevated risk of MASLD in both the cross-sectional and prospective analyses. In the cross-sectional analysis, the adjusted odds ratios (ORs) of MASLD increased stepwise over reticulocyte count quartiles (quartile 2: OR 1.22, 95% CI 1.17–1.28, p < 0.001; quartile 3: OR 1.44; 95% CI 1.38–1.51, p < 0.001; quartile 4: OR 1.66, 95% CI 1.59–1.74, p < 0.001). The results of prospective analyses were similar.

Conclusion: Increased reticulocyte count was independently associated with a higher risk of MASLD. This discovery offers new insights into the potential of reticulocytes as biomarkers for MASLD.
In Vitro evaluation of the anti-pancreatic cancer activity of epimedium herb
Authors: Chen Yangfeng , Xia Han , Zhong Xiaohong
Published: July 2024

Introduction: Pancreatic cancer (PC) is a particularly aggressive malignancy with limited therapeutic options. The search for innovative treatments has focused on traditional Chinese medicine, specifically epimedium. This research investigates epimedium’s active ingredients, potential targets, and underlying mechanisms in treating PC.

Methods: High-performance liquid chromatography (HPLC) was used to quantify the active components of epimedium and HPLC-Q-TOF-MS was employed for qualitative identification. Potential targets of epimedium’s active ingredients were identified using the TCMSP, ETCM, CTD, and Swiss Target Prediction databases. Potential PC-related targets were sourced from DisGeNET, GeneCards, and OMIM databases. A Venn diagram was utilized to identify overlapping PC-related and epimedium targets. Core targets and pathways were elucidated through protein-protein interaction (PPI) network analysis, Gene Ontology (GO) assessments, and Reactome pathway enrichment analyses. Molecular docking techniques investigated interactions between active compounds and these targets. The expression and prognostic implications of target genes were evaluated using GEPIA2 and the Human Protein Atlas (HPA) databases. In vitro studies assessed the impact of epimedium extract (EPE) on Panc-1 cell viability, and Western blot analysis examined the expression levels of key targets.

Results: Network pharmacological indicate that epimedium econtains active components such as baohuoside I, icariin, hyperoside, and epimedin B, which have potential therapeutic effects against PC. In vitro assays confirmed that EPE significantly reduced the viability of Panc-1 cells. Western blot analysis revealed a considerable decrease in the expression of key targets in EPE-treated cells, including AKT1, EGFR, p-EGFR, JUN, BCL2, IL6, and SRC. The R-HSA-1280215: Interleukin-4 and Interleukin-13 signaling pathways involving these genes were identified as potential therapeutic targets.

Discussion:Epimedium holds promise as a candidate for treating PC. The modulation of interleukin-4 and interleukin-13 signaling pathways could be a pivotal mechanism by which epimedium impedes tumor development. Further research is warranted to validate these findings and explore the clinical applicability of epimedium in PC treatment.
Promiscuous potato: elucidating genetic identity and the complex genetic relationships of a cultivated potato germplasm collection
Authors: Anglin Noelle L. , Chavez Oswaldo , Soto - Torres Julian , Gomez Rene , Panta Ana , Vollmer Rainer , Durand Marisol , Meza Charo , Azevedo Vania , Manrique - Carpintero Norma C. , Kauth Philip , Coombs Joesph J. , Douches David S. , Ellis David
Published: July 2024

A total of 3,860 accessions from the global in trust clonal potato germplasm collection w3ere genotyped with the Illumina Infinium SolCAP V2 12K potato SNP array to evaluate genetic diversity and population structure within the potato germplasm collection. Diploid, triploid, tetraploid, and pentaploid accessions were included representing the cultivated potato taxa. Heterozygosity ranged from 9.7% to 66.6% increasing with ploidy level with an average heterozygosity of 33.5%. Identity, relatedness, and ancestry were evaluated using hierarchal clustering and model-based Bayesian admixture analyses. Errors in genetic identity were revealed in a side-by-side comparison of in vitro clonal material with the original mother plants revealing mistakes putatively occurring during decades of processing and handling. A phylogeny was constructed to evaluate inter- and intraspecific relationships which together with a STRUCTURE analysis supported both commonly used treatments of potato taxonomy. Accessions generally clustered based on taxonomic and ploidy classifications with some exceptions but did not consistently cluster by geographic origin. STRUCTURE analysis identified putative hybrids and suggested six genetic clusters in the cultivated potato collection with extensive gene flow occurring among the potato populations, implying most populations readily shared alleles and that introgression is common in potato. Solanum tuberosum subsp. andigena (ADG) and S. curtilobum (CUR) displayed significant admixture. ADG likely has extensive admixture due to its broad geographic distribution. Solanum phureja (PHU), Solanum chaucha (CHA)/Solanum stenotomum subsp. stenotomum (STN), and Solanum tuberosum subsp. tuberosum (TBR) populations had less admixture from an accession/population perspective relative to the species evaluated. A core and mini core subset from the genebank material was also constructed. SNP genotyping was also carried out on 745 accessions from the Seed Savers potato collection which confirmed no genetic duplication between the two potato collections, suggesting that the collections hold very different genetic resources of potato. The Infinium SNP Potato Array is a powerful tool that can provide diversity assessments, fingerprint genebank accessions for quality management programs, use in research and breeding, and provide insights into the complex genetic structure and hybrid origin of the diversity present in potato genetic resource collections.
The potential of non-native tree species to provide major ecosystem services in Austrian forests
Authors: Konic Julia , Heiling Carina , Haeler Elena , Chakraborty Debojyoti , Lapin Katharina , Schueler Silvio
Published: July 2024

Forestry is facing an unprecedented challenging time. Due to climate change, major tree species, which until recently fulfilled major ecosystem services, are being lost and it is often unclear if forest conversion with other native or non-native tree species (NNT) are able to maintain or restore the endangered ecosystem services. Using data from the Austrian Forest Inventory, we analysed the current and future (2081-2100, RCP 4.5 and RCP 8.5) productivity of forests, as well as their protective function (avalanches and rockfall). Five different species change scenarios were considered for the replacement of a tree species failing in the future. We used seven native tree species (Picea abies, Abies alba, Pinus sylvestris, Larix decidua, Fagus sylvatica, Quercus robur and Quercus petraea) and nine NNT (Pseudotsuga menziesii, Abies grandis, Thuja plicata, Pinus radiata, Pinus contorta, Robinia pseudoacacia, Quercus rubra, Fraxinus pennsylvanica and Juglans nigra). The results show that no adaptation would lead to a loss of productivity and a decrease in tree species richness. The combined use of native and NNT is more favorable than purely using native species in terms of productivity and tree species richness. The impact of the different species change scenarios can vary greatly between the different environmental zones of Austria (Alpine south, Continental and Pannonian). The Pannonian zone would benefit from the use of NNT in terms of timber production. For the protection against avalanches or rockfall in alpine regions, NNT would not be an advantage, and it is more important if broadleaved or coniferous trees are used. Depending on whether timber production, protective function or tree species richness are considered, different tree species or species change scenarios can be recommended. Especially in protective forests, other aspects are essential compared to commercial forests. Our results provide a basis for forest owners/managers in three European environmental zones to make decisions on a sustainable selection of tree species to plant in the face of climate change.
Yogi or fireball – or both – a diary study on the interaction between mindfulness and vigor on job performance
Authors: Blume Johanna Barbara , Dettmers Jan
Published: July 2024

Introduction

Building upon the conservation of resources theory and the episodic process model of performance, this research addresses the gap in understanding how daily variations in two personal resources, particularly their interaction, affect job performance. Specifically, this study examines the influence of vigor and mindfulness on daily fluctuations in task performance considering the potential compensation effect between these personal resources in the workplace.

Methods

We conducted a five-day online diary study involving 192 participants (926 daily observations). At the conclusion of each workday, participants were asked to assess their level of mindfulness and vigor in the workplace using validated scales, as well as estimate their task performance.

Results

Multilevel analyses showed that both daily mindfulness and daily vigor positively predict self-reported task performance. The interaction between mindfulness and vigor was significant. The results suggest that high levels of mindfulness can compensate for low levels of vigor, and vice versa.

Discussion

Exploring the interplay of personal resources at work provides a valuable starting point for individual-tailored interventions that enable individuals to reach their full potential. Enhancing employees’ mindfulness may increase job performance directly and empowers workers to compensate for periods of low energy.
The effects of Nirvana fitness and functional training on the body appreciation of young women: non-randomized controlled trial
Authors: Jankauskiene Rasa , Balciuniene Vaiva , Rutkauskaite Renata , Pajaujiene Simona , Baceviciene Migle
Published: July 2024

Introduction

Exercise is an important intervention used to improve body image. The present non-randomized controlled trial aimed to examine the effects of Nirvana Fitness (NF) and functional training (FT) on body appreciation and its correlates in young women.

Methods

Twenty-two students participated in FT, 21 in NF, and 47 in the control (CN) group. The mean age of the study participants was 22.79 ± 6.14 years. The FT and NF groups participated in sessions 2 days per week for 8 weeks, and the CN group did not participate in any sessions. All the participants were evaluated at pre- and post-intervention, filling in the Body Appreciation Scale 2 (BAS-2), Mind–Body Connection from the Physical Activity Body Experiences Questionnaire (PABEQ), Body Surveillance from the Objectified Body Consciousness Scale (OBCS), the Functionality Appreciation Scale (FAS), intrinsic exercise motivation from Behavioral Regulation in Exercise Questionnaire 2 (BREQ-2), and perceived physical fitness.

Results

Significant improvements were found in terms of all outcome measures in the FT group, and improvements of body and mind connection and body surveillance in the NF group, while no improvements were observed in the CN group. FT’s effect on body appreciation appeared to operate through the improvement of the mind–body connection in the FT and NF groups and via decreased body surveillance in the FT group.

Conclusion

These findings support the developmental theory of embodiment and provide initial evidence that professionally delivered FT and NF might be used as effective strategies for the promotion of positive body image in young women.
Family resilience in a social-ecological context – emotional difficulties and coping strategies
Authors: Vladislav Elena Otilia , Marc Gabriela , Paica Corina-Ioana , Pop Ovidiu
Published: July 2024

Introduction

This research explored how crises such as the pandemic influence the family dynamic and the way that the parents and the children face new difficulties and challenges. The present study investigates children’s and young people’s emotional states, the dimensions of family resilience, and the types of coping strategies and parents’ emotional states during the coronavirus pandemic. The final sample for the research was represented by 1,010 parents from Romania.

Methods

The present scientific research is a transversal study with the scope to understand the emotional difficulties that parents and children/ young people face and the coping strategies that they adopt in a crisis, such as the time of the coronavirus pandemic.

Results

Parents with maladaptive coping strategies are more affected by the pandemic. Also, the results indicate that there is a significant correlation between parental coping strategies and the children’s emotional states, and the adaptability level. Therefore, the high scores on the subscales which measure maladaptive coping indicate high scores of the levels of depression, anxiety, and stress of the parents. Family resilience, through the dimension of ‘communication and problem-solving in the family’ has a moderation role in the relationship between parental depression and the maladaptive coping strategy of rumination. Family resilience through ‘maintaining a positive attitude’ has a moderation role in the relationship between catastrophizing and the teenagers’ level of adaptability.

Discussion

The results of the study pointed out the role and place of family resilience within the family system and how a period of crisis can affect this system.
Art and mentalizing in early intervention psychosis: rationale and therapist insights on a new psychoeducational course
Authors: Parkinson Sarah , Cole Bethany , Trevelyan Clare
Published: July 2024

In this paper, we explore the rationale for a combined art therapy and mentalization-based treatment (MBT) group course for those experiencing a first episode of psychosis (FEP). We discuss the theoretical background for how art and MBT theory can help us better understand and work with groups of individuals experiencing FEP, particularly focusing on avoidance and insecure attachment styles. We outline the delivery of a ten-week psychoeducational Art MBT course within an Early Intervention in Psychosis (EIP) Service and discuss our experiential insights into this new modality as co-therapists. We conclude by proposing that art therapy and mentalizing practice together offer an accessible, useful and practical group structure for EIP services, which could improve individuals’ mentalizing capacity and overall social functioning.
The impact of digital finance on young People’s health insurance participation decisions in China
Authors: Chai Mengran , Wu Lin
Published: July 2024

Background

The digital finance era has reshaped young people’s lifestyles, risk perceptions and insurance participation decisions. Modern youth have to constantly seek for rational social security support and construct individual protection barriers to adapt to new lifestyles and social structures. China’s multi-tiered, universal health insurance system is urgently needed to satisfy young people’s flexible needs and rational decision-making.

Methods

Based on the micro data from 2011 ~ 2021 Chinese General Social Survey (CGSS), this paper uses macro data from Digital Inclusive Finance Index (DIFI) matching to construct probit and m-logit model to assess the impact of the development of digital finance on Chinese youth whether or not to participate in health insurance, and how they choose the concrete type of health insurance.

Results

(1) Baseline regression results shows that digital finance has a significant positive effect on Chinese youth’s health insurance participation decisions, and has different effects on choices within health insurance types. Strong support for the conclusions is provided by endogeneity and robustness tests. (2) The results of the heterogeneity analysis reveal that the marginal effect of digital finance on young people’s health insurance decisions shows urban–rural differences, divergence in levels of self-rated health. (3) The mechanism analysis results suggest that there are two mechanism paths of digital finance on youth health insurance decisions: the household income effect and the subjective well-being effect, and two moderating effects: employment type and family structure.

Conclusion

Highlighting the positive value that digital finance brings to the perception of youth insurance participation and the construction of social security systems, it needs to pay close attention to the dynamic changes in employment security and family structure through data, and explore the socio-psychological fluctuation and demand for social security among modern youth. To provide a way forward to achieve the integration of the health insurance system in China and solve the current problem of health insurance equity.
Emotional reactions and stigmatization after a parricide in South Tyrol, Italy, among mental health professionals and the general population, including persons with mental disorders, relatives, and persons with no direct or indirect contact
Authors: Stockner Mara , Wenter Anna , Obexer Artur , Gualtieri Isabella , Merler Francesca , Bennato Davide , Conca Andreas
Published: July 2024

Introduction

This study was conducted on the occasion of the parricide in Bolzano (South Tyrol, Italy) in January 2021. The psychological impact of parricide on the general population and on mental health professionals has scarcely been investigated to the present day. Studies on stigmatization show differences between various groups. The aim was to analyze the emotional reactions to the parricide and the stigmatization of persons with mental disorders in the South Tyrolian population.

Methods

In September 2022, 121 mental health professionals of the Department of Psychiatry in Bolzano were surveyed using an online questionnaire. In addition, from January to March 2023, the general population of South Tyrol was invited to take part in the survey through an online-link and was divided into three groups: 267 persons with mental health problems, 855 relatives and 1,019 persons with no direct or indirect contact to people with mental problems. The validated Reported and Intended Behavior Scale (RIBS) was used together with questions on the emotional reactions to the parricide and the perceived dangerousness of psychiatric patients. Descriptive statistics, one-way Anovas as well as regressions were carried out.

Results and discussion

All groups experienced sadness the most. Relatives experienced more sadness and anger than the other groups. Over 80% of the professionals stated that psychiatric patients were not at greater risk of committing parricide. The population with no contact rated the risk higher than those affected and had the lowest level of openness (RIBS). There were no differences between genders, but there were age differences, with younger people being more stigmatizing. The results suggest that personal contact, appropriate information, and education are associated with less stigmatization.
Assessing mental health literacy in Jordan: a factor analysis and Rasch analysis study
Authors: Al-Qerem Walid , Jarab Anan , Khdour Maher , Eberhardt Judith , Alasmari Fawaz , Hammad Alaa , Zumot Ruba , Khalil Sarah
Published: July 2024

Background

Mental health literacy (MHL) research in Jordan is sparse and validated MHL measures are lacking. The present study validated a Jordanian version of the Mental Health Literacy Scale (MHLS) and examined Jordanian individuals’ MHL.

Method

A Google Forms survey was designed, and the link was shared through various Jordanian social media platforms. Factor analysis and Rasch analysis were performed to validate the Jordanian version of the MHLS. Binary logistic regression was performed to assess variables associated with MHL.

Results

The Jordanian MHLS was administered to 974 participants (74.4% females; median age 27 years). The mean MHL score of the participants was 71.1% indicating average literacy levels. The factor analysis indicated that 27 items distributed across four factors had the best model fit. The Rasch analysis confirmed item separation reliability and person reliability. The regression showed a correlation between educational attainment, income, marital status and MHL level. These findings emphasize the role of educational attainment in MHL, pointing to the necessity of integrating mental health education into formal curricula to enhance MHL across all societal levels. Stigma and limited-service availability act as barriers to mental health service and access, which compound the challenge of improving MHL. Targeted educational interventions and policy reforms may help improve MHL, thereby contributing to improving mental health outcomes in Jordan and potentially other similar settings.
Radio transients from compact objects across the mass spectrum in the era of multi-messenger astronomy
Authors: Corsi Alessandra , Eddins Avery , Lazio T. Joseph W. , Murphy Eric J. , Osten Rachel A.
Published: July 2024

Compact objects across the mass spectrum–from neutron stars to supermassive black holes–are progenitors and/or central engines for some of the most cataclysmic phenomena in the Universe. As such, they are associated with radio emission on a variety of timescales and represent key targets for multi-messenger astronomy. Observations of transients in the radio band can unveil the physics behind their central engines, ejecta, and the properties of their surroundings, crucially complementing information on their progenitors gathered from observations of other messengers (such as gravitational waves and neutrinos). In this contribution, we summarize observational opportunities and challenges ahead in the multi-messenger study of neutron stars and black holes using radio observations. We highlight the specific contribution of current U.S. national radio facilities and discuss expectations for the field focusing on the science that could be enabled by facilities recommended by the 2020 Decadal survey such as the next generation Very Large Array (ngVLA).
Between-rater reliability for using radar technology to quantify maximal horizontal deceleration performance in NCAA division 1 American football and female lacrosse athletes
Authors: Philipp Nicolas M. , McKay Ben , Martin Ethan , Cabarkapa Dimitrije , Fry Andrew C. , Troester Jordan
Published: July 2024

Introduction

With recent increases in the popularity of studying the physical construct of horizontal deceleration performance in team-sport athletes, the aim of the present study was to assess the inter-rater and intra-rater reliability of processing and quantifying horizontal deceleration ability using radar technology.

Methods

Data from 92 NCAA Division 1 athletes from two different athletic teams (American football and Lacrosse) were used for the present investigation. All athletes performed two trials of the modified acceleration to deceleration assessment (ADA), which consisted of a maximal 10 m sprint acceleration, followed by a rapid deceleration. Four individual raters manually processed raw, radar-derived instantaneous velocity data for the ADA, and an automated script was used to calculate metrics of interest.

Results

Primary study findings suggest moderate to excellent levels of agreement (ICC = 0.56–0.91) for maximal horizontal deceleration metrics between the four individual raters. The intra-rater analyses revealed poor to excellent consistency (ICC = 0.31–0.94) between ADA trials, with CV%'s ranging from 3.1% to 13.2%, depending on the respective metric and rater.

Discussion

Our data suggests that if a foundational understanding and agreement of manual data processing procedures for radar-derived data is given between raters, metrics may be interpreted with moderate to excellent levels of confidence. However, when possible, and when using the Stalker ATS radar technology, authors recommend that practitioners use one trained individual to manually process raw data. Ideally, this process should become fully automated, based on selected filters or algorithms, rather than the subjectivity of the rater.
A systematic review of LGBTQ+ identities and topics in sport leadership
Authors: O’Connell Colleen S. , Bottino Anna
Published: July 2024

Introduction

As individuals with occupational status and power, sport leaders (e.g., coaches and athletic administrators) are responsible for enforcing cultures of inclusion within institutions of athletics. Yet, sport leaders who possess LGBTQ+ sexual identities are frequently marginalized and stigmatized by entities within and outside of athletics (e.g., athletes, parents of athletes, colleagues). Therefore, LGBTQ+ sport leaders are often faced with a challenging set of circumstances: negotiate the authenticity of their sexual orientation in the context of sport, or leave the profession entirely.

Methods

The purpose of this study was to conduct a systematic review of research related to LGBTQ+ sport leader experiences. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), research across six countries (China/Taiwan/Hong Kong, Italy, New Zealand, Norway, United Kingdom, United States) between 1997 and 2021 was analyzed.

Results

Themes across included studies (N = 34) describe intrapersonal experiences of LGBTQ+ sport leaders, interpersonal studies examining stakeholder attitudes (i.e., parents and athletes) toward LGBTQ+ sport leaders, and sport manager attitudes toward LGBTQ+ topics.

Discussion

Findings convey that sport leaders continue to face marginalization due to the presence of heterosexism and heteronormativity in athletics. Future research should continue to explore LGBTQ+ sport leader experiences, behaviors, attitudes, and identities to determine their impact on fostering inclusion and belonging within athletic spaces.