bluuebunny/crossref_metadata_2025 huggingface dataset:
New Insights into Synthetic Copper Greens: The Search for Specific Signatures by Raman and Infrared Spectroscopy for Their Characterization in Medieval Artworks
Authors: Buse Juliana , Otero Vanessa , Melo Maria
Published: June 2019

A systematic investigation of medieval copper green pigments was carried out based on written sources: 21 manuscripts, dating from 50–70 to 1755 AD, were sourced and 77 recipes were selected, translating into 44 experiments. Reconstructions from medieval recipes were prepared and characterized through a multianalytical approach to disclose the original pigment formulation that is often described as verdigris. Based on the results obtained, we propose three main groups of copper green pigments, group 1, in which only Cu(CH3COO)2·H2O is formed; group 2, where this acetate is found together with copper oxalates; group 3, in which atacamite is present as the major green component or as a signature compound. The products formed are in perfect agreement with that predicted by the state-of-the-art research on the mechanisms of atmospheric corrosion of copper. This knowledge, together with our experience on craft recipes to prepare medieval paint materials, allowed us to recover a lost medieval recipe to produce a copper green pigment based mainly on atacamite, a basic copper chloride, which has been recently detected, by Raman and infrared spectroscopy, in artworks ranging from Catalonia and the Crown of Aragon panel painting to Islamic manuscripts.
Development of a WebGIS-Based Analysis Tool for Human Health Protection from the Impacts of Prescribed Fire Smoke in Southeastern USA
Authors: Hu Yongtao , Ai Ha Hang , Odman Mehmet Talat , Vaidyanathan Ambarish , Russell Armistead G.
Published: June 2019

We have developed the Southern Integrated Prescribed Fire Information System (SIPFIS) to disseminate prescribed fire information, including daily forecasts of potential air quality impacts for southeastern USA. SIPFIS is a Web-based Geographic Information Systems (WebGIS) assisted online analysis tool that provides easy access to air quality and fire-related data products, and it facilitates visual analysis of exposure to smoke from prescribed fires. We have demonstrated that the information that SIPFIS provides can help users to accomplish several fire management activities, especially those related to assessing environmental and health impacts associated with prescribed burning. SIPFIS can easily and conveniently assist tasks such as checking residential community-level smoke exposures for personal use, pre-screening for fire-related exceptional events that could lead to air quality exceedances, supporting analysis for air quality forecasts, and the evaluation of prescribed burning operations, among others. The SIPFIS database is currently expanding to include social vulnerability and human health information, and this will evolve to bring more enhanced interactive functions in the future.
Health Disparities of Employees in Taiwan with Major Cancer Diagnosis from 2004 to 2015: A Nation- and Population-Based Analysis
Authors: Hsu Ya-Yuan , Bai Chyi-Huey , Wang Chung-Ching , Chen Wei-Liang , Wu Wei-Te , Lai Ching-Huang
Published: June 2019

Background: Health disparities related to environmental exposure exist in different industries. Cancer is currently a leading cause of morbidity and mortality worldwide. Much remains unknown about the types of work and industries that face the greatest cancer risks. In this study, we aimed to provide the overall and specific cancer incidences among all workers from 2004 to 2015. We also aimed to show the all-cause mortality for all employees with a first-ever cancer diagnosis. Methods: All workers in Taiwan in the labor insurance database in 2004–2015 were linked to the national health insurance databases. The annual overall and specific cancer incidences in 2004–2015 were calculated and stratified by industry and gender. Age-standardized incidence rates were also calculated. Results: A total of 332,575 workers (46.5% male) who had a first-ever cancer diagnosis from 2004–2015 were identified from 16,720,631 employees who provided 1,564,593 person-years of observation. The fishing, wholesale, construction, and building industries were identified as high-risk industries, with at least 5% of employees within them receiving a first-ever cancer diagnosis. Temporal trends of cancer incidences showed a range from 235.5 to 294.4 per 100,000 with an overall upward trend and an increase of 1.3-fold from 2004 to 2015. There were significant increases over that time for breast cancer (25%); colon cancer (8%); lung, bronchial, and tracheal cancers (11%); and oral cancer (1.7%). However, the incidence rates of cervical cancer and liver and intrahepatic cholangiocarcinoma decreased by 11.2% and 8.3%, respectively. Among the 332,575 workers with a first-ever cancer diagnosis, there were 110,692 deaths and a mortality rate of 70.75 per 1000 person-years. Conclusions: The overall incidence of cancer increased over the 10-year study period, probably due to the aging of the working population. High-risk industries are concentrated in the labor-intensive blue-collar class, which is related to aging and socioeconomic status intergradation.
Introducing of Online Channel and Management Strategy for Green Agri-food Supply Chain based on Pick-Your-Own Operations
Authors: Hu Qifan , Xu Qianyun , Xu Bing
Published: June 2019

The popularity of e-commerce has impacted traditional retail business. Farmer cooperatives running green agri-food pick-your-own (PYO) farms are facing the choice of whether or not to adopt online channels. PYO operation refers to consumers picking and purchasing the agri-food growing on a farm, and due to it being environmentally-friendly, healthy, and popular, it has been widely adopted by many farm cooperatives. This paper aims to discuss the practicality of introducing online channels to already established PYO farms in the green agri-food supply chain (GASC), who can personally take charge of the online channel or transfer it to one online retailer. Firstly, we constructed the demand functions of green agri-food by putting consumer utility, the freshness of agri-food, and transportation cost into consideration. Secondly, five decision models are built to characterize five operation modes, namely pure PYO mode, self-operated dual-channel mode, decentralized dual-channel mode, centralized dual-channel mode, and contractual cooperation mode. Furthermore, by taking price, demand, and profit with different modes into consideration, we are able to explore the introduction of online channels and green brand construction. Finally, numerical analysis is performed. We found that: (1) introducing an online channel is preferable strategy since the profit of the farmer cooperative in pure PYO mode is always less than the profit of a farmer cooperative in non-self-operated dual-channel modes; (2) the decision of self-operating an online channel is related to the fixed cost of creating a new online channel and the green food brand effect of online channel, and it is the optimal mode in some cases, while the contractual cooperation mode is the optimal mode in the remaining cases; and (3) the green food brand effect of online channels is does not necessarily improve with scale, and the initial freshness has a positive relationship to the profit, demand, and price of farmer cooperatives and online retailers.
Burnout and Metabolic Syndrome in Female Nurses: An Observational Study
Authors: Chico-Barba Gabriela , Jiménez-Limas Karime , Sánchez-Jiménez Bernarda , Sámano Reyna , Rodríguez-Ventura Ana Lilia , Castillo-Pérez Rafael , Tolentino Maricruz
Published: June 2019

Nurses are at risk of having burnout due to workload and job stress—studies have reported that chronic stress is associated with metabolic syndrome. This study aimed to assess the association between burnout and metabolic syndrome in a sample of female nurses. Data were collected from a cross-sectional study from 2016 to 2018 in a tertiary hospital in Mexico City. All nurses that work in the hospital were invited to participate. Information pertaining to sociodemographic (age, education level), work (labor seniority, service area, shift work), anthropometric (weight, waist circumference, blood pressure) and biochemical (glucose, serum lipids) variables were collected. Burnout was assessed using the Maslach Burnout Inventory test, and metabolic syndrome was defined according to the International Diabetes Federation criteria. A total of 168 nurses participated with a median age of 44 years. The prevalence of burnout and metabolic syndrome was 19.6% and 38.7%, respectively. There was no association between burnout and metabolic syndrome (p = 0.373). However, associations of emotional exhaustion (aOR: 14.95; 95% CI: 1.5–148.7), personal accomplishment (aOR: 0.13; 95% CI: 0.01–0.99), and night shift (aOR: 12.39; 95% CI: 1.02–150.5) with increased waist circumference were found. Strategies are needed to prevent burnout and metabolic syndrome in nurses, especially in those who work at night shift.
The Respiratory Burst Oxidase Homolog D (RbohD) Cell and Tissue Distribution in Potato–Potato Virus Y (PVYNTN) Hypersensitive and Susceptible Reactions
Authors: Otulak-Kozieł Katarzyna , Kozieł Edmund , Valverde Rodrigo A.
Published: June 2019

The respiratory burst oxidase homolog D (RbohD) acts as a central driving force of reactive oxygen species signaling in plant cells by integrating many different signal transduction pathways in plants, including incompatible interactions with pathogens. This study demonstrated the localization and distribution of RbohD in two types of potato–potato virus Y (PVY) interactions: Compatible and incompatible (resistant). The results indicated a statistically significant induction of the RbohD antigen signal in both interaction types. In the hypersensitive response (resistant reaction) of potato with a high level of resistance to the potato tuber necrotic strain of PVY (PVYNTN), RbohD localization followed by hydrogen peroxide (H2O2) detection was concentrated in the apoplast. In contrast, in the hypersensitive response of potato with a low resistance level to PVYNTN, the distribution of RbohD was concentrated more in the plant cell organelles than in the apoplast, resulting in the virus particles being present outside the inoculation area. Moreover, when compared to mock-inoculated plants and to the hypersensitive response, the PVYNTN-compatible potato interaction triggered high induction in the RbohD distribution, which was associated with necrotization. Our findings indicated that RbohD and hydrogen peroxide deposition was associated with the hypersensitive response, and both were detected in the vascular tissues and chloroplasts. These results suggest that the RbohD distribution is actively dependent on different types of PVY NTN-potato plant interactions. Additionally, the RbohD may be involved in the PVYNTN tissue limitation during the hypersensitive response, and it could be an active component of the systemic signal transduction in the susceptible host reaction.
CAIX Regulates Invadopodia Formation through Both a pH-Dependent Mechanism and Interplay with Actin Regulatory Proteins
Authors: Debreova Michaela , Csaderova Lucia , Burikova Monika , Lukacikova Lubomira , Kajanova Ivana , Sedlakova Olga , Kery Martin , Kopacek Juraj , Zatovicova Miriam , Bizik Jozef , Pastorekova Silvia , Svastova Eliska
Published: June 2019

Tumor metastasis is tightly linked with invasive membrane protrusions, invadopodia, formed by actively invading tumor cells. Hypoxia and pH modulation play a role in the invadopodia formation and in their matrix degradation ability. Tumor-associated carbonic anhydrase IX (CAIX), induced by hypoxia, is essential for pH regulation and migration, predisposing it as an active component of invadopodia. To investigate this assumption, we employed silencing and inhibition of CA9, invadopodia isolation and matrix degradation assay. Quail chorioallantoic membranes with implanted tumor cells, and lung colonization assay in murine model were used to assess efficiency of in vivo invasion and the impact of CAIX targeting antibodies. We showed that CAIX co-distributes to invadopodia with cortactin, MMP14, NBCe1, and phospho-PKA. Suppression or enzymatic inhibition of CAIX leads to impaired invadopodia formation and matrix degradation. Loss of CAIX attenuated phosphorylation of Y421-cortactin and influenced molecular machinery coordinating actin polymerization essential for invadopodia growth. Treatment of tumor cells by CAIX-specific antibodies against carbonic or proteoglycan domains results in reduced invasion and extravasation in vivo. For the first time, we demonstrated in vivo localization of CAIX within invadopodia. Our findings confirm the key role of CAIX in the metastatic process and gives rationale for its targeting during anti-metastatic therapy.
Antimicrobial Polymers: The Potential Replacement of Existing Antibiotics?
Authors: Kamaruzzaman Nor Fadhilah , Tan Li Peng , Hamdan Ruhil Hayati , Choong Siew Shean , Wong Weng Kin , Gibson Amanda Jane , Chivu Alexandru , Pina Maria de Fatima
Published: June 2019

Antimicrobial resistance is now considered a major global challenge; compromising medical advancements and our ability to treat infectious disease. Increased antimicrobial resistance has resulted in increased morbidity and mortality due to infectious diseases worldwide. The lack of discovery of novel compounds from natural products or new classes of antimicrobials, encouraged us to recycle discontinued antimicrobials that were previously removed from routine use due to their toxicity, e.g., colistin. Since the discovery of new classes of compounds is extremely expensive and has very little success, one strategy to overcome this issue could be the application of synthetic compounds that possess antimicrobial activities. Polymers with innate antimicrobial properties or that have the ability to be conjugated with other antimicrobial compounds create the possibility for replacement of antimicrobials either for the direct application as medicine or implanted on medical devices to control infection. Here, we provide the latest update on research related to antimicrobial polymers in the context of ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) pathogens. We summarise polymer subgroups: compounds containing natural peptides, halogens, phosphor and sulfo derivatives and phenol and benzoic derivatives, organometalic polymers, metal nanoparticles incorporated into polymeric carriers, dendrimers and polymer-based guanidine. We intend to enhance understanding in the field and promote further work on the development of polymer based antimicrobial compounds.
Serum Levels of Interleukin-6 and Titers of Antibodies against Porphyromonas gingivalis Could Be Potential Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma
Authors: Park Dae-Gun , Woo Bok Hee , Lee Byung-Joo , Yoon Sanggyeong , Cho Youngseuk , Kim Yong-Deok , Park Hae Ryoun , Song Jae Min
Published: June 2019

It has been suggested that Porphyromonas gingivalis (P. gingivalis), a keystone pathogen in chronic periodontitis, is associated with a variety of cancers, including oral cancer. Recently, studies have shown the effects of persistent exposure to P. gingivalis on the promotion of tumorigenic properties of oral epithelial cells, suggesting that chronic P. gingivalis infection is a potential risk factor for oral cancer. On the other hand, Fusobacterium nucleatum (F. nucleatum), one of the major periodontal pathogens, has emerged as an important factor in the colon cancer progression. Here, we investigated the diagnostic potential of serum immunoglobulin G antibody against periodontal pathogens, P. gingivalis and F. nucleatum, and serum IL-6 for oral squamous cell carcinoma (OSCC). An enzyme-linked immunosorbent assay (ELISA) was used to determine and compare the serum levels of interleukin 6 (IL-6), F. nucleatum IgG, and P. gingivalis IgG in 62 OSCC patients with 46 healthy controls. The serum levels of P. gingivalis IgG and IL-6 were higher in OSCC patients than in non-OSCC controls, and the difference was statistically significant. In addition, a high serum level of IL-6 was associated with a worse prognosis in OSCC patients. Thus, P. gingivalis IgG and IL-6 could be utilized as potential serum biomarkers for the diagnosis of OSCC, and the serum level of IL-6 contributes to improved prognostic performance.
Investigating Users’ Continued Usage Intentions of Online Learning Applications
Authors: Ji Zhi , Yang Zhenhua , Liu Jianguo , Yu Changrui
Published: June 2019

Understanding users’ continued usage intentions for online learning applications is significant for online education. In this paper, we explore a scale to measure users’ usage intentions of online learning applications and empirically investigate the factors that influence users’ continued usage intentions of online learning applications based on 275 participant data. Using the extended Technology Acceptance Model (TAM) and the Structural Equation Modelling (SEM), the results show that males or users off campus are more likely to use online learning applications; that system characteristics (SC), social influence (SI), and perceived ease of use (PEOU) positively affect the perceived usefulness (PU), with coefficients of 0.74, 0.23, and 0.04, which imply that SC is the most significant to the PU of online learning applications; that facilitating conditions (FC) and individual differences (ID) positively affect the PEOU, with coefficients of 0.72 and 0.37, which suggest that FC is more important to the PEOU of online learning applications; and that both PEOU and PU positively affect the behavioral intention (BI), with coefficients of 0.83 and 0.51, which indicate that PEOU is more influential than PU to users’ continued usage intentions of online learning applications. In particular, the output quality, perceived enjoyment, and objective usability are critical to the users’ continued usage intentions of online learning applications. This study contributes to the technology acceptance research field with a fast growing market named online learning applications. Our methods and results would benefit both academics and managers with useful suggestions for research directions and user-centered strategies for the design of online learning applications.
Mexican Rice Borer Control Tactics in United States Sugarcane
Authors: Showler Allan T.
Published: June 2019

The invasive Mexican rice borer, Eoreuma loftini (Dyar), expanded its range from Mexico to South Texas in the early 1980s. By 2008 the pest had moved into sugarcane- and rice-growing areas of East Texas and Louisiana, and by 2012 it was reported on noncrop host plants in Florida. Efforts to suppress E. loftini in United States sugarcane with chemicals and biological control agents were unsuccessful, so both tactics were discontinued, and E. loftini infestation of sugarcane has continued unchecked. During the last 15 years, however, research has focused on the pest’s ecology, improved insecticides and scouting methods, the identification of sugarcane resistance mechanisms, and new cultural tactics. A surveillance technique was developed that indicates when larvae are most vulnerable to insecticide sprays. Currently, registered insecticides for E. loftini control are not widely applied, although some show promise, including an insect growth regulator. A number of potentially useful cultural practices are available, including plowing under fallow stubble, judicious use of fertilizer, adequate irrigation, avoiding proximity to E. loftini-susceptible maize cultivars, and enhancement of natural enemy populations. Demonstrated and potentially useful sugarcane resistance mechanisms involve physiochemical attributes, physical characteristics, and transgenic cultivars.
Ischemia Reperfusion Injury Produces, and Ischemic Preconditioning Prevents, Rat Cardiac Fibroblast Differentiation: Role of KATP Channels
Authors: Pertiwi Kartika R. , Hillman Rachael M. , Scott Coralie A. , Chilton Emily Lisa
Published: June 2019

Ischemic preconditioning (IPC) and activation of ATP-sensitive potassium channels (KATP) protect cardiac myocytes from ischemia reperfusion (IR) injury. We investigated the influence of IR injury, IPC and KATP in isolated rat cardiac fibroblasts. Hearts were removed under isoflurane anesthesia. IR was simulated in vitro by application and removal of paraffin oil over pelleted cells. Ischemia (30, 60 and 120 min) followed by 60 min reperfusion resulted in significant differentiation of fibroblasts into myofibroblasts in culture (mean % fibroblasts ± SEM in IR vs. time control: 12 ± 1% vs. 63 ± 2%, 30 min ischemia; 15 ± 3% vs. 71 ± 4%, 60 min ischemia; 8 ± 1% vs. 55 ± 2%, 120 min ischemia). IPC (15 min ischemia, 30 min reperfusion) significantly attenuated IR-induced fibroblast differentiation (52 ± 3%) compared to 60 min IR. IPC was mimicked by opening KATP with pinacidil (50 μM; 43 ± 6%) and by selectively opening mitochondrial KATP (mKATP) with diazoxide (100 μM; 53 ± 3%). Furthermore, IPC was attenuated by inhibiting KATP with glibenclamide (10 μM; 23 ± 5%) and by selectively blocking mKATP with 5-hydroxydecanoate (100 μM; 22 ± 9%). These results suggest that (a) IR injury evoked cardiac fibroblast to myofibroblast differentiation, (b) IPC attenuated IR-induced fibroblast differentiation, (c) KATP were involved in IPC and (d) this protection involved selective activation of mKATP.
Role of Patient Sex in Early Recovery from Alcohol-Related Cognitive Impairment: Women Penalized
Authors: Luquiens Amandine , Rolland Benjamin , Pelletier Stéphanie , Alarcon Régis , Donnadieu-Rigole Hélène , Benyamina Amine , Nalpas Bertrand , Perney Pascal
Published: June 2019

Background: The objective was to explore the role of patient sex in cognitive recovery and to identify predictive factors for non-recovery in alcohol use disorder (AUD). Methods: All patients with AUD admitted to a residential addictions treatment center were systematically assessed at admission and after 6 weeks of abstinence in a controlled environment. The inclusion criteria were that patients were admitted for AUD with baseline alcohol-related cognitive impairment (baseline total Montreal Cognitive Assessment (MoCA) score < 26) and reassessed at 6 weeks (n = 395). A logistic regression model was built to determine the influence of sex on recovery status (MoCA < or ≥ 26) taking into account the interaction effect of sex with alcohol consumption on cognitive function. Results: The mean age was 50.10 years (SD = 9.79), and 27.41% were women. At baseline, the mean MoCA scores were 21.36 (SD = 3.04). Participants who did not achieve recovery (59.3% of women vs 53.8% of men) had lower total MoCA scores at baseline. The 2 factors that was significantly and independently associated with non-recovery and with a non-zero coefficient was being a woman and initial MoCA score (respective adjusted odds ratios (AOR) = 1.5 and 0.96, p-values < 0.05). Conclusions: These results could influence the time required in a controlled environment to maintain abstinence and the duration of in-care for women.
Carbohydrate-Rich Diet Is Associated with Increased Risk of Incident Chronic Kidney Disease in Non-Diabetic Subjects
Authors: Nam Ki Heon , An Seong Yeong , Joo Young Su , Lee Sangmi , Yun Hae-Ryong , Jhee Jong Hyun , Han Seung Hyeok , Yoo Tae-Hyun , Kang Shin-Wook , Park Jung Tak
Published: June 2019

Despite the potential relationship with metabolic derangements, the association between dietary carbohydrate intake and renal function remains unknown. The present study investigated the impact of dietary carbohydrate intake on the development of incident chronic kidney disease (CKD) in a large-scale prospective cohort with normal renal function. A total of 6746 and 1058 subjects without and with diabetes mellitus (DM) were analyzed, respectively. Carbohydrate intake was assessed by a 24-h dietary recall food frequency questionnaire. The primary endpoint was CKD development, defined as a composite of estimated glomerular filtration rate (eGFR) of ≤60 mL/min/1.73 m2 and the development of proteinuria. CKD newly developed in 20.1% and 36.0% of subjects during median follow-ups of 140 and 119 months in the non-DM and DM subjects, respectively. Categorization of non-DM subjects into dietary carbohydrate density quartiles revealed a significantly higher risk of CKD development in the third and fourth quartiles than in the first quartile (P = 0.037 for first vs. third; P = 0.001 for first vs. fourth). A significant risk elevation was also found with increased carbohydrate density when carbohydrate density was treated as a continuous variable (P = 0.008). However, there was no significant difference in the incident CKD risk among those with DM according to dietary carbohydrate density quartiles. Carbohydrate-rich diets may increase the risk of CKD development in non-DM subjects.
On the Locus of the Practice Effect in Sustained Attention Tests
Authors: Blotenberg Iris , Schmidt-Atzert Lothar
Published: June 2019

The present study set out to explore the locus of the poorly understood but frequently reported and comparatively large practice effect in sustained attention tests. Drawing on a recently proposed process model of sustained attention tests, several cognitive tasks were administered twice in order to examine which specific component of test performance benefitted from practice and to which extent. It was shown that the tasks representing the three sub-components of sustained attention tests, namely the perception of an item, the simple mental operation to solve an item, and the motor reaction to indicate a response to an item, benefitted from practice. Importantly, the largest practice gain was observed for the task that required item-solving processes in addition to perceptual and motor processes. Two additional postulated mechanisms in sustained attention tests—the deliberate shifting between items and the preprocessing of upcoming items—did not become more efficient through practice. Altogether, the present study shows that the practice effect in sustained attention tests seems to be primarily due to faster item-solving processes and, to a limited extent, due to a faster perception of the item, as well as a faster motor response. Moreover, besides the sub-components, it is likely that also the coordination of perceptual, item-solving, and motor processes benefitted from practice. Altogether, the present paper may have taken a first step towards a better understanding of the specific processes that cause the large practice gains in sustained attention tests.
Introduction
Authors: Nieuwenhuijsen Dorien , Garachana Camarero Mar
Published: June 2019

It is a commonly known fact that language change can be observed at different linguistic levels, which correspond to the traditional disciplines of phonology, morphology, syntax and semantics [...]
(E)-3-(2,5-Dimethoxyphenyl)-1-{[4-(2,5-dimethoxy-phenyl)-6-((E)-2,5-dimethoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]}prop-2-en-1-one and (E)-3-(2,5-Dimethoxyphenyl)-1-{[4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]}prop-2-en-1-one
Authors: Suwito Hery , Kurnyawaty Noorma , Susetyo Ellyca , Azizah Yuzkiya , Haq Kautsar Ul , Novi Kristanti Alfinda , Indriani Indriani
Published: June 2019

Dihydropyrimidine derivatives possess great potential to be used as a precursor for the synthesis of wide diverse dihydropyrimidine-like derivatives. In this research, the title compounds were synthesized through the reaction between 5-acetyl-4-(2,5-dimethoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-thione and 2,5-dimethoxybenzladehyde under aldol condensation condition. The title compound, (E)-3-(2,5-dimethoxyphenyl)-1-{[(4-(2,5-dimethoxyphenyl)-6-((E)-2,5-dimethoxystyryl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)]}prop-2-en-1-one (yield 15%), was obtained as major product, whereas (E)-3-(2,5-dimethoxyphenyl)-1-{[(4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro pyrimidin-5-yl)]}prop-2-en-1-one (yield 8%) as side product through vinylogous aldol condensation.
Experimental and Electrochemical Research of an Efficient Corrosion and Scale Inhibitor
Authors: Chen Yanmin , Xing Weiwei , Wang Ling , Chen Lingxia
Published: June 2019

A novel corrosion and scale inhibitor (TPP) containing tobacco stem extract (TSE), polyepoxysuccinic acid (PESA), and polyaspartic acid (PASP) was obtained by the optimal proportion of the orthogonal test. The anticorrosion effect of TPP for carbon steel was researched by static weight-loss method, on-line simulated dynamic test, electrochemical measurement, and scanning electron microscopy (SEM). The results showed that TPP could protect carbon steel efficiently with a maximal corrosion inhibition rate of 85.7% and it was a mixed-type corrosion inhibitor, mainly exhibiting cathode suppression capacity. Simultaneously, the results of calcium carbonate deposition experiment indicated that the scale inhibition rate of TPP was up to 100%.
Design and Prototyping of Miniaturized Straight Bevel Gears for Biomedical Applications
Authors: Acinapura Antonio , Fragomeni Gionata , Greco Pasquale Francesco , Mundo Domenico , Carbone Giuseppe , Danieli Guido
Published: June 2019

This paper presents a semi-automated design algorithm for computing straight bevel gear involute profiles. The proposed formulation is based on the Tredgold approximation method. It allows the design of a pair of bevel gears with any desired number of teeth and relative axes inclination angles by implementing additive manufacturing technology. A specific case study is discussed to calculate the profiles of two straight bevel gears of a biomedical application. Namely, this paper illustrates the design of the bevel gears for a new laparoscopic robotic system, EasyLap, under development with a grant from POR Calabria 2014–2020 Fesr-Fse. A meshing analysis is carried out to identify potential design errors. Moreover, finite element-based tooth contact analysis is fulfilled for determining the vibrational performances of the conjugate tooth profiles throughout a whole meshing cycle. Simulation results and a built prototype are reported to show the engineering feasibility and effectiveness of the proposed design approach.
Combining the Magnetic Equivalent Circuit and Maxwell–Fourier Method for Eddy-Current Loss Calculation
Authors: Benmessaoud Youcef , Dubas Frédéric , Hilairet Mickael
Published: June 2019

In this paper, a hybrid model in Cartesian coordinates combining a two-dimensional (2-D) generic magnetic equivalent circuit (MEC) with a 2-D analytical model based on the Maxwell–Fourier method (i.e., the formal resolution of Maxwell’s equations by using the separation of variables method and the Fourier’s series) is developed. This model coupling has been applied to a U-cored static electromagnetic device. The main objective is to compute the magnetic field behavior in massive conductive parts (e.g., aluminum, magnets, copper, iron) considering the skin effect (i.e., with the eddy-current reaction field) and to predict the eddy-current losses. The magnetic field distribution for various models is validated with 2-D and three-dimensional (3-D) finite-element analysis (FEA). The study is also focused on the discretization influence of 2-D generic MEC on the eddy-current loss calculation in conductive regions. Experimental tests and 3-D FEA have been compared with the proposed approach on massive conductive parts in aluminum. For an operating point, the computation time is divided by ~4.6 with respect to 3-D FEA.
Lipidomic Signatures Reveal Seasonal Shifts on the Relative Abundance of High-Valued Lipids from the Brown Algae Fucus vesiculosus
Authors: da Costa Elisabete , Domingues Pedro , Melo Tânia , Coelho Elisabete , Pereira Rui , Calado Ricardo , Abreu Maria H. , Domingues M. Rosário
Published: June 2019

Fucus vesiculosus is an edible brown macroalga, with health benefits associated with its consumption and also a source of bioactive molecules. It is acknowledged that the biochemical composition of macroalgae changes when exposed to different environmental conditions occurring on different habitats, such as the water temperature, and light intensity. In the present study, the polar lipidome of Fucus vesiculosus was characterized for the first time using modern high-resolution HILIC–MS, and MS/MS approaches, to evaluate the phenotypic variability in two seasons of the year, e.g., winter and spring. A total of 187 molecular species were identified over eighteen classes of glycolipids, phospholipids and betaine lipids. Principal component analysis (PCA) multivariate statistical analysis and cluster analysis of polar lipid classes, polar lipid species and total fatty acids (FA) datasets, showed clustering according to the seasonal groups. While the lipid profile of Fucus vesiculosus harvested in the winter and spring yielded the same molecular species, the relative abundance of these species was significantly different. In the winter, changes were mainly due to the increased relative abundance of some molecular species of glycolipids and phospholipids, bearing octadeca(poly)enoic (18:3, 18:4) and eicosa(poly)enoic (20:4, 20:5) FA and betaine lipids species with short saturated FA (14:0) and polyunsaturated FA (PUFA). Importantly, glycolipids with n-3 PUFA and sulfolipids, have been reported to have important biological activities and therapeutic value. Overall, Fucus vesiculosus is a promising source of bioactive compounds that can be used as functional food or ingredients for human nutrition, feed, pharma, and cosmetic formulations. In this study, samples harvested in the winter season maximized yields of these bioactive components, when compared with samples harvested in the spring.
Knowledge and Attitude Among Lebanese Pregnant Women Toward Cord Blood Stem Cell Storage and Donation
Authors: Saleh Fatima A.
Published: June 2019

Background: Umbilical cord blood (UCB) used to be considered waste material and was discarded at birth. However, cord blood is now considered a rich source of adult stem cells that can be used to treat many conditions and diseases. This study was performed to determine pregnant women’s knowledge and attitudes toward cord blood stem cell banking and donation in Lebanon. Methods: A descriptive study was conducted in antenatal clinics in Beirut and data were collected using a questionnaire distributed to pregnant women after provision of informed consent. A total of 244 women responded. Results: Less than half of the women (46%) reported knowledge about cord blood banking. However, participants with university and secondary education had significantly higher odds of considering UCB storage compared to those with primary education (odds ratio (OR) 8.62, 95% confidence interval (CI) 2.74–27.15 and OR 21.23,95% CI 6.55–68.86, respectively). Older pregnant women were less likely to think about UCB stem cells storage (OR 0.92, 95% CI 0.85–0.98). Conclusion: Respondents who had an existing knowledge about UCB stem cells banking in general were more likely to consider storing UCB in blood banks if affordable (45.9%). Therefore, it is necessary to inform pregnant women about stem cell banking so that they can make the appropriate decisions for themselves.
Cerebrospinal Fluid Analysis in Multiple Sclerosis Diagnosis: An Update
Authors: Lo Sasso Bruna , Agnello Luisa , Bivona Giulia , Bellia Chiara , Ciaccio Marcello
Published: June 2019

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS) with brain neurodegeneration. MS patients present heterogeneous clinical manifestations in which both genetic and environmental factors are involved. The diagnosis is very complex due to the high heterogeneity of the pathophysiology of the disease. The diagnostic criteria have been modified several times over the years. Basically, they include clinical symptoms, presence of typical lesions detected by magnetic resonance imaging (MRI), and laboratory findings. The analysis of cerebrospinal fluid (CSF) allows an evaluation of inflammatory processes circumscribed to the CNS and reflects changes in the immunological pattern due to the progression of the pathology, being fundamental in the diagnosis and monitoring of MS. The detection of the oligoclonal bands (OCBs) in both CSF and serum is recognized as the “gold standard” for laboratory diagnosis of MS, though presents analytical limitations. Indeed, current protocols for OCBs assay are time-consuming and require an operator-dependent interpretation. In recent years, the quantification of free light chain (FLC) in CSF has emerged to assist clinicians in the diagnosis of MS. This article reviews the current knowledge on CSF biomarkers used in the diagnosis of MS, in particular on the validated assays and on the alternative biomarkers of intrathecal synthesis.
A New Theoretical Approach of Wall Transpiration in the Cavity Flow of the Ferrofluids
Authors: Siddiqui Abuzar Abid , Turkyilmazoglu Mustafa
Published: June 2019

An idea of permeable (suction/injection) chamber is proposed in the current work to control the secondary vortices appearing in the well-known lid-driven cavity flow by means of the water based ferrofluids. The Rosensweig model is conveniently adopted for the mathematical analysis of the physical problem. The governing equation of model is first transformed into the vorticity transport equation. A special finite difference method in association with the successive over-relaxation method (SOR) is then employed to numerically simulate the flow behavior. The effects of intensity of magnetic source (controlled by the Stuart number), aspect ratio of the cavity, rate of permeability (i.e., α p = V 0 U ), ratio of speed of suction/injection V 0 to the sliding-speed U of the upper wall of a cavity, and Reynolds number on the ferrofluid in the cavity are fully examined. It is found that the secondary vortices residing on the lower wall of the cavity are dissolved by the implementation of the suction/injection chamber. Their character is dependent on the rate of permeability. The intensity of magnetic source affects the system in such a way to alter the flow and to transport the fluid away from the magnetic source location. It also reduces the loading effects on the walls of the cavity. If the depth of cavity (or the aspect ratio) is increased, the secondary vortices join together to form a single secondary vortex. The number of secondary vortices is shown to increase if the Reynolds number is increased for both the clear fluid as well as the ferrofluids. The suction and injection create resistance in settlement of solid ferroparticles on the bottom. The results obtained are validated with the existing data in the literature and satisfactory agreement is observed. The presented problem may find applications in biomedical, pharmaceutical, and engineering industries.
The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression
Authors: Mudgapalli Nithya , Shaw Brianna P. , Chava Srinivas , Challagundla Kishore B.
Published: June 2019

The Transcribed-Ultra Conserved Regions (T-UCRs) are a class of novel non-coding RNAs that arise from the dark matter of the genome. T-UCRs are highly conserved between mouse, rat, and human genomes, which might indicate a definitive role for these elements in health and disease. The growing body of evidence suggests that T-UCRs contribute to oncogenic pathways. Neuroblastoma is a type of childhood cancer that is challenging to treat. The role of non-coding RNAs in the pathogenesis of neuroblastoma, in particular for cancer development, progression, and therapy resistance, has been documented. Exosmic non-coding RNAs are also involved in shaping the biology of the tumor microenvironment in neuroblastoma. In recent years, the involvement of T-UCRs in a wide variety of pathways in neuroblastoma has been discovered. Here, we present an overview of the involvement of T-UCRs in various cellular pathways, such as DNA damage response, proliferation, chemotherapy response, MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)) amplification, gene copy number, and immune response, as well as correlate it to patient survival in neuroblastoma.
Rheological and Mechanical Characterization of Dual-Curing Thiol-Acrylate-Epoxy Thermosets for Advanced Applications
Authors: Russo Claudio , Fernández-Francos Xavier , De la Flor Silvia
Published: June 2019

Mechanical and rheological properties of novel dual-curing system based on sequential thiol-acrylate and thiol-epoxy reactions are studied with the aim of addressing the obtained materials to suitable advanced applications. The crosslinking process is studied by rheological analysis in order to determine conversion at gelation and the critical ratio. These parameters are used to discuss the intermediate material structure for each acrylate proportion and their possible application in the context of dual-curing and multi-step processing scenarios. Results from dynamo-mechanical analysis and mechanical testing demonstrate the high versatility materials under investigation and revealed a wide range of achievable final properties by simply varying the proportion between acrylate and thiol group. The intermediate stability between curing stages has been analysed in terms of their thermal and mechanical properties, showing that these materials can be stored at different temperatures for a relevant amount of time without experiencing significant effects on the processability. Experimental tests were made to visually demonstrate the versatility of these materials. Qualitative tests on the obtained materials confirm the possibility of obtaining complex shaped samples and highlight interesting shape-memory and adhesive properties.
Vision-Based Assisted Tele-Operation of a Dual-Arm Hydraulically Actuated Robot for Pipe Cutting and Grasping in Nuclear Environments
Authors: Bandala Manuel , West Craig , Monk Stephen , Montazeri Allahyar , Taylor C. James
Published: June 2019

This article investigates visual servoing for a hydraulically actuated dual-arm robot, in which the user selects the object of interest from an on-screen image, whilst the computer control system implements via feedback control the required position and orientation of the manipulators. To improve on the current joystick direct tele-operation commonly used as standard in the nuclear industry, which is slow and requires extensive operator training, the proposed assisted tele-operation makes use of a single camera mounted on the robot. Focusing on pipe cutting as an example, the new system ensures that one manipulator automatically grasps the user-selected pipe, and appropriately positions the second for a cutting operation. Initial laboratory testing (using a plastic pipe) shows the efficacy of the approach for positioning the manipulators, and suggests that for both experienced and inexperienced users, the task is completed significantly faster than via tele-operation.
Building Instance Change Detection from Large-Scale Aerial Images using Convolutional Neural Networks and Simulated Samples
Authors: Ji Shunping , Shen Yanyun , Lu Meng , Zhang Yongjun
Published: June 2019

We present a novel convolutional neural network (CNN)-based change detection framework for locating changed building instances as well as changed building pixels from very high resolution (VHR) aerial images. The distinctive advantage of the framework is the self-training ability, which is highly important in deep-learning-based change detection in practice, as high-quality samples of changes are always lacking for training a successful deep learning model. The framework consists two parts: a building extraction network to produce a binary building map and a building change detection network to produce a building change map. The building extraction network is implemented with two widely used structures: a Mask R-CNN for object-based instance segmentation, and a multi-scale full convolutional network for pixel-based semantic segmentation. The building change detection network takes bi-temporal building maps produced from the building extraction network as input and outputs a building change map at the object and pixel levels. By simulating arbitrary building changes and various building parallaxes in the binary building map, the building change detection network is well trained without real-life samples. This greatly lowers the requirements of labeled changed buildings, and guarantees the algorithm’s robustness to registration errors caused by parallaxes. To evaluate the proposed method, we chose a wide range of urban areas from an open-source dataset as training and testing areas, and both pixel-based and object-based model evaluation measures were used. Experiments demonstrated our approach was vastly superior: without using any real change samples, it reached 63% average precision (AP) at the object (building instance) level. In contrast, with adequate training samples, other methods—including the most recent CNN-based and generative adversarial network (GAN)-based ones—have only reached 25% AP in their best cases.
A Censored Shifted Mixture Distribution Mapping Method to Correct the Bias of Daily IMERG Satellite Precipitation Estimates
Authors: Ma Qiumei , Xiong Lihua , Xia Jun , Xiong Bin , Yang Han , Xu Chong-Yu
Published: June 2019

Satellite precipitation estimates (SPE) provide useful input for hydrological modeling. However, hydrological modeling is frequently hindered by large bias and errors in SPE, inducing the necessity for bias corrections. Traditional distribution mapping bias correction of daily precipitation commonly uses Bernoulli and gamma distributions to separately model the probability and intensities of precipitation and is insufficient towards extremes. This study developed an improved distribution mapping bias correction method, which established a censored shifted mixture distribution (CSMD) as a transfer function when mapping raw precipitation to the reference data. CSMD coupled the censored shifted statistical distribution to jointly model both the precipitation occurrence probability and intensity with a mixture of gamma and generalized Pareto distributions to enhance extreme-value modeling. The CSMD approach was applied to correct the up-to-date SPE of Integrated Multi-satelliE Retrievals for Global Precipitation Measurement (GPM) with near-real-time “Early” run (IMERG-E) over the Yangtze River basin. To verify the hydrological response of bias-corrected IMERG-E, the streamflow of the Wujiang River basin was simulated using Ge´nie Rural with 6 parameters (GR6J) and Coupled Routing Excess Storage (CREST) models. The results showed that the bias correction using both BerGam (traditional bias correction combining Bernoulli with gamma distributions) and the improved CSMD could reduce the systematic errors of IMERG-E. Furthermore, CSMD outperformed BerGam in correcting overall precipitation (with the median of mean absolute errors of 2.46 mm versus 2.81 mm for CSMD and BerGam respectively, and the median of modified Nash–Sutcliffe efficiency of 0.39 versus 0.29) and especially in extreme values for uniform format and particular attention paid to extremes. In addition, the hydrological effect that CSMD correction exerted on IMERG-E, driving GR6J and CREST rainfall-runoff modeling, outperformed that of the BerGam correction. This study provides a promising integrated distribution mapping framework to correct the biased daily SPE, contributing to more reliable hydrological forecasts by informing accurate precipitation forcing.