bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing tribo-mechanical and corrosion properties of A383 aluminum matrix composites through stir-cum-squeeze casting with marble dust and hexagonal boron nitride reinforcement
Authors: Murugadoss Palanivendhan , Jeyaseelan Chandradass
Published: February 2024

The A383 aluminum matrix composites (AMCs) are prominent automotive materials owing to their low-density yet high-strength nature. However, the conventional casting techniques, exorbitant price, and scarce supply of traditional ceramic reinforcements remain challenging. This research countermeasure the challenges by hybridizing the A383 with industrial marble dust (MD) and hexagonal boron nitride (hBN) through the stir-cum-squeeze casting technique. A constant proportion (4 wt%) of MD waste and varying proportions of hBN (1.5, 3, 4.5, and 6 wt%) were used to reinforce A383 alloy to improve its physio-mechanical characteristics. Stir-cum-squeeze casting enables homogenous dispersion of reinforcement particles within the matrix, resulting in improved interfacial bonding. Optimal results were achieved for A383 alloy reinforced with 4 wt% of MD and 6 wt% hBN, ensuring balanced tribo-mechanical characteristics against the as-casted A383. The hardness value increased by 40.8%, while the compression and tensile strength increased by 30.8% and 115.8%, respectively. Non-destructive testing confirms the effective reduction of porosity in the stir-cum-squeeze-cast composites. Moreover, the hybrid composites exhibit improved corrosion resistance by 32.18% after 72 h of testing. Additionally, the hybrid composites demonstrate a wear rate reduction of 54.35%.
Scratch performance of natural rubber and natural rubber composites reinforced with nylon, kevlar, and carbon fabrics
Authors: Wang Xin , Wong Shing-Chung , Gao Xiaosheng , Moon Soon W. , Xie Yongsong
Published: February 2024

The scratch performance of natural rubber (NR) and fibre-reinforced NR was investigated using a scratch test with acoustic emission (AE). Both maximum penetration depth and maximum tangential force were characterised by two procedures. Procedure 1 applied the corner of a steel cube at face leading orientation. Procedure 2 applied a steel pyramid indenter with a spherical tip at the edge leading orientation. AE was adopted in Procedure 2 for evaluation of cutting damage mode that varied from ploughing/tearing the matrix to cutting both the matrix and fabric. The scratched regions of all specimens were observed using an optical microscope to estimate the damage level and examine damage mechanisms. The results show that scratch resistance improved as fibre content and fibre stiffness increased. The maximum tangential force depended on the damage modes. Two or more fabric layers could further increase penetration resistance, but the damage level is more serious in most cases.
French and language ideologies in a multilingual European Union institution: Re-constructing the meaning of language choice at work
Authors: Lovrits Veronika , Langinier Hélène , Ehrhart Sabine
Published: February 2024

This qualitative study investigates stances in reflective interviews to identify cultural patterns that shape the meaning of language choice within an international unit of an EU institution in Luxembourg. We employ the analytical concept of “language cringe” and propose a complementary concept, “language push,” to showcase the effects and reproduction of language ideologies in day-to-day talk about languages at work. Our analysis reveals that, within a workplace culture that encourages flexible and convivial use of multiple languages, French speakers have to deal with the effects of the “logic of honour,” which is culturally associated with the use of French in France. Based on our findings, we suggest that language choice should be considered a cross cultural dimension in multilingual environments, and that language-sensitive management scholarship should broaden its considerations beyond the traditional issues of language proficiency, namely by inspecting relational and affective factors that shape language use in multilingual workplaces.
Gross negligence manslaughter of intern doctors – scapegoating or justified?
Authors: Lin Wing Hin Kason
Published: February 2024

Criminalizing unintentional mistakes in medicine as the offence of gross negligence manslaughter has always been a contentious issue. The threshold of prosecution is not well-defined, and even less clear when faced with a situation in which an intern doctor is held liable. This commentary attempts to review the current legal position of holding an intern doctor liable for gross negligence medical manslaughter.
Characteristics of ADHD Symptoms and EEG Theta/Beta Ratio in Children With Sleep Disordered Breathing
Authors: Ma Dandi , Wu Yunxiao , Wang Changming , Zhao Fujun , Xu Zhifei , Ni Xin
Published: February 2024

Objectives. This study aimed to explore parent-reported symptoms of attention deficit-hyperactivity disorder (ADHD) and sleep electroencephalogram (EEG) theta/beta ratio (TBR) characteristics in children with sleep disordered breathing (SDB). Methods. The parents of children (aged 6-11 years) with SDB (n = 103) and healthy controls (n = 28) completed the SNAP-IV questionnaire, and children underwent overnight polysomnography. Children with SDB were grouped according to obstructive apnea/hypopnea index: primary snoring, mild, and moderate-severe obstructive sleep apnea (OSA) groups. The TBR in non-rapid eye movement (NREM) periods in three sleep cycles was analyzed. Results. Children with SDB showed worse ADHD symptoms compared with the healthy control. There was no intergroup difference in TBR. The time-related decline in TBR observed in the control, primary snoring and mild OSA groups, which was not observed in the moderate-severe OSA group. Overnight transcutaneous oxygen saturation was negatively associated with the hyperactivity/impulsivity score of ADHD symptom. The global TBR during the NREM period in the first sleep cycle was positively correlated with inattention score. Conclusion. Children with SDB showed more ADHD inattention symptoms than the healthy control. Although we found no difference in TBR among groups, we found significant main effect for NREM period. There existed a relationship between hypoxia, TBR, and scores of ADHD symptoms. Hence, it was speculated that TBR can reflect the nocturnal electrophysiological manifestations in children with SDB, which may be related to daytime ADHD symptoms.
Games for the Pluriverse: Exploring the Use, Opportunities, and Problems of Drawing from Local Cultural Heritage in Video Games
Authors: Eklund Lina , Gluzman Renard , Jørgensen Kristine , Kayali Fares , Roinioti Elina , Pnueli Vered
Published: February 2024

In this paper, we explore the growing trend of European game developers embracing their cultural heritage with greater dedication. Taking a bottom-up approach, we showcase various successful examples of games that engage with local cultural canons. Additionally, we investigate how games can evolve into creators of cultural heritage by examining those that have already achieved such status. Furthermore, we delve into the potential fusion between independent games and cultural heritage by presenting several paradigms and posing pertinent questions about this evolution. Our study offers a framework that envisions games with strong local identities from diverse regions forming transnational networks and agencies within the videogame industry. Such developments could give rise to a new European game scene that draws inspiration primarily from local heritages, thereby fueling creativity and innovation in the field.
Evaluation of Turkish Academic and Student Attitudes on Plagiarism: Validity and Reliability of the Plagiarism Attitudes Scale
Authors: Özbek Güven Gamze , Inceoğlu Feyza , Yilmaz Şerife , Ince Fuat
Published: February 2024

The main purpose of this study was to translate the Plagiarism Attitude Scale into Turkish and validate it for use in Turkish settings, in order to better understand research integrity attitudes and awareness of the Turkish academic and student community, while also contributing an instrument for research in this area. The research was designed and conducted with 483 participants. In the process of adapting the scale to Turkish, language, content, and construct validity analyses were performed. Following the completion of the validity phase, the reliability of the scale was examined using Cronbach's alpha coefficient and the split-half method. The results indicate that the scale's language and content validity are deemed sufficient. According to the findings of the research, the Plagiarism Attitude Scale, in its adapted Turkish version, is considered a valid and reliable tool. The use of this Turkish scale will assist local researchers in sharing their unique perspectives and help the international community better understand research ethics concerns in Türkiye. Additionally, this scale will serve as a valuable resource for planning educational programs.
Long-term clinical outcomes in patients with multiple sclerosis who are initiating disease-modifying therapy with natalizumab compared with BRACETD first-line therapies
Authors: Butzkueven Helmut , Kalincik Tomas , Patti Francesco , Slee Mark , Weinstock-Guttman Bianca , Buzzard Katherine , Skibina Olga , Alroughani Raed , Prat Alexandre , Girard Marc , Horakova Dana , Havrdova Eva Kubala , Van der Walt Anneke , Eichau Sara , Hyde Robert , Campbell Nolan , Bodhinathan Karthik , Spelman Tim ,   MSBase Investigators
Published: February 2024

Background:

Aggressive disease control soon after multiple sclerosis (MS) diagnosis may prevent irreversible neurological damage, and therefore early initiation of a high-efficacy disease-modifying therapy (DMT) is of clinical relevance.

Objectives:

Evaluate long-term clinical outcomes in patients with MS who initiated treatment with either natalizumab or a BRACETD therapy (interferon beta, glatiramer acetate, teriflunomide, or dimethyl fumarate).

Design:

This retrospective analysis utilized data from MSBase to create a matched population allowing comparison of first-line natalizumab to first-line BRACETD.

Methods:

This study included patients who initiated treatment either with natalizumab or a BRACETD DMT within 1 year of MS diagnosis and continued treatment for ⩾6 months, after which patients could switch DMTs or discontinue treatment. Patients had a minimum follow-up time of ⩾60 months from initiation. A subgroup analysis compared the natalizumab group to patients in the BRACETD group who escalated therapy after 6 months. Outcomes included unadjusted annualized relapse rates (ARRs), time-to-first relapse, time-to-first confirmed disability improvement (CDI), and time-to-first confirmed disability worsening (CDW).

Results:

After 1:1 propensity score matching, 355 BRACETD patients were matched to 355 natalizumab patients. Patients initiating natalizumab were less likely to experience a relapse over the duration of follow-up, with ARRs [95% confidence interval (CI)] of 0.080 (0.070–0.092) for natalizumab patients and 0.191 (0.178–0.205) for BRACETD patients ( p < 0.0001). A Cox regression model of time-to-first relapse showed a reduced risk of relapse for natalizumab patients [hazard ratio (95% CI) of 0.52 (0.42–0.65); p < 0.001] and a more favorable time-to-first CDI. The risk of CDW was similar between groups. The subgroup analysis showed an increased relapse risk as well as a significantly higher risk of CDW for BRACETD patients.

Conclusion:

Early initiation of natalizumab produced long-term benefits in relapse outcomes in comparison with BRACETD, regardless of a subsequent escalation in therapy.
Ethnomedicinal, Phytochemical, and Pharmacological Properties of Diospyros mollis Griff.: A Review
Authors: Chen Tran Van , Nghia Nguyen Trong , Nhat Truong Le Van , Khanh Linh Nguyen Hoang
Published: February 2024

Objective/Background

The genus Diospyros L. (Ebenaceae) includes about 778 species worldwide, with over 500 of them known for their significant health benefits. Among them, Diospyros mollis Griff. has been used as a tonic and treatment for many diseases related to digestive disorders and intestinal parasites. Furthermore, the fruit has also been used for dyeing silk fabrics. The purpose of this comprehensive review is to provide researchers with important information about D. mollis, particularly regarding its chemical composition and biological effects. This information can support current understanding and future studies to develop novel herbal formulations based on this species. Additionally, this review aims to compile and summarize the available literature on this species, covering its botanical, ethnomedicinal, phytochemical, and pharmacological properties reported to date.

Methods

The relevant information on D. mollis was collected via online electronic and databases, including Scopus, Pubmed, Web of Science, Google Scholar, ScienceDirect, Springer Link, SciFinder, and other scientific databases.

Results

A comprehensive review of the literature reveals that D. mollis contains various chemical constituents such as naphthalene and naphthoquinone derivatives, triterpenoids, alkaloids, sterols, glycosides, and fatty acid esters isolated from the berry, root, bark, and leaf of this species, with several pharmacological effects and other applications. Many pharmacological effects, such as hyaluronidase inhibitory, anthelmintic, and antiparasitic activities of various extracts and isolated compounds of D. mollis, are reported in this review. The review demonstrates the importance of D. mollis in the treatment of diseases, its application in fabric dyeing techniques, and its traditional use.

Conclusion

In conclusion, D. mollis emerges as a promising botanical resource with its rich history in traditional medicine and diverse chemical constituents, paving the way for potential future applications and innovations in the field of herbal medicine and drug development.
A rare concomitant ipsilateral hip and knee dislocations: A case report and review of the literature
Authors: Jlidi Mohamed , Bouaicha Walid , Mallek Karim , Gharbi Mohamed Hedi , Jaziri Salma , Daas Selim
Published: February 2024

Ipsilateral hip and knee dislocation is a rare and complex injury that usually results from high-energy trauma. Only 14 cases were reported in the literature so far. We report the case of a 35-year-old man who presented with an ipsilateral right hip and knee dislocation after being involved in a road traffic accident. A contralateral floating knee was associated. The hip dislocation was associated to a posterior wall fracture of the acetabulum and a femoral head fracture. The knee dislocation was compound and associated with a patella fracture. The hip dislocation was reduced. The posterior wall and the femoral head fractures were treated conservatively. The knee dislocation was reduced and stabilized by external fixator. Early postoperative infection occurred and was treated surgically. At the last follow-up, the knee was ankylosed at 5° of flexion with a bony bridge between the femoral condyle and the tibial plateau. The patient described an occasional hip pain on exertion. He had full range of motion of the right hip. No avascular necrosis of the femoral head was seen. Outcomes of simultaneous hip and knee dislocation are very variable and remain unpredictable. The timing of reducing the hip joint and the knee.
Stand up and be counted: Using traffic cameras to assess voting behavior in real time
Authors: Dietrich Bryce J. , Ko Hyein , Sen Payel
Published: February 2024

Despite their ubiquity, few have used traffic camera networks for social science research. Using 1,312,977 images collected from 768 London-based cameras leading up to the 2015 UK general election, this study not only demonstrates how traffic camera data can be used to effectively measure same-day turnout, but we also provide ways such data can be used to assess political behavior more broadly. Such automated enumeration is especially important in countries where official results are only returned for the current election, making it difficult for those interested in assessing turnout at lower levels of aggregation, even when those elections are next on the calendar. Although we are not the first to suggest the value of images-as-data, this study hopes to underline the importance of video-as-data, while simultaneously offering an important foundation for future research.
Predicting the Probability of Tumor-Specific Survival in Patients Diagnosed With Primary Tumors in the Spinal Cord Using Nomogram Models
Authors: Huang Chao , Tang Tingting , Ding Zichuan , Wang Haoyang , Zhou Zongke
Published: February 2024

Study Design

A retrospective cohort study.

Objective

The goal of this study was to develop a useful clinical prediction nomogram to accurately predict the cancer-specific survival (CSS) of patients with primary spinal cord tumor (SCT), thereby formulating scientific prevention and aiding clinical decision-making.

Methods

In this study, patients with SCT diagnoses from the surveillance, epidemiology, and end results (SEER) database (2000-2018) were taken into account. Initially, a nomogram was created using the CSS-associated independent factors that were determined from both univariate and multivariable Cox regression analyses. Furthermore, the nomogram’s capacity for calibration, ability to discriminate, and actual clinical effectiveness were assessed through calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA), respectively. Finally, a strategy for categorizing SCT patients’ risk was developed.

Results

This study included 909 SCT individuals. A novel nomogram was developed to forecast SCT patients’ CSS, taking into account age, histological type, tumor grade, tumor stage, and radiotherapy. These factors were identified as independent prognostic indicators for CSS in SCT patients. Elderly SCT patients with distant metastasis, advanced tumor grade, received radiotherapy, and confirmed lymphoma have a poor prognosis. Meanwhile, the risk classification system could differentiate SCT patients and realize targeted management.

Conclusions

The developed nomogram has the ability to accurately forecast the CSS in SCT individuals, aiding in precise decision-making during clinical practice, enhancing health planning, maximizing treatment advantages, and ultimately improving patient prognosis.
Outcomes and Return to Sport After Knee Osteochondral Allograft Transplant in Professional Athletes
Authors: Allahabadi Sachin , Quigley Ryan , Frazier Landon , Joyce Kaitlyn , Cole Brian J.
Published: February 2024

Background:

Limited data are available on the outcomes and return-to-sport rates after osteochondral allograft transplant in professional athletes.

Purpose:

To evaluate the experience of a single senior surgeon in treating professional athletes with osteochondral allograft transplant, including analyzing clinical outcomes and return to sport.

Study Design:

Case series; Level of evidence, 4.

Methods:

The authors performed a retrospective review of professional athletes treated with primary osteochondral allograft to the knee between January 1, 2001, and January 1, 2021, by a single surgeon. Athletes were required to play at the professional level in their sport and have a minimum of 2 years of follow-up. Return-to-sport rates and timing were evaluated. Patient-reported outcomes were assessed preoperatively and at final follow-up. Reoperations and failures were also tabulated.

Results:

The study included 15 professional athletes who represented a variety of sports, with follow-up at a mean of 4.91 ± 2.2 years (range, 2.0-9.4 years). The majority (8 athletes; 53%) had undergone prior surgeries to the operative knee. Eleven (73%) returned to sport at a mean of 1.22 ± 0.4 years (range, 0.75-2 years), and of the 8 undergoing isolated osteochondral allograft, 7 (87.5%) returned at 1.28 ± 0.3 years. Ten athletes (66.7% of total; 90.9% of those who returned) returned to sport at the same level or higher compared with before surgery. Significant improvements were seen in each assessed patient-reported outcome score at final follow-up. Two of the 3 (66.7%) patients who underwent concomitant meniscal allograft transplant were able to return to sport at the same level or higher than presurgery. Three (20%) underwent second-look arthroscopy, 1 (6.7%) of whom underwent cartilage debridement of the osteochondral allograft.

Conclusion:

Osteochondral allograft transplant in professional athletes can result in a high rate of return to play at a similar or higher level as presurgery, even when performed with concomitant procedures such as meniscal allograft transplant. High-level athletes should expect significant postoperative improvement in clinical outcomes.
Impact of Age on Cognitive Testing Practice Effects and Cardiorespiratory Responses
Authors: Reddy Priyanka M. , Abdali Kulsum , Ross Sarah E. , Davis Sandra , Mallet Robert T. , Shi Xiangrong
Published: February 2024

Objective: This study tested the hypothesis that healthy aging attenuates cognitive practice effects and, consequently, limits the familiarity-associated reductions in heart rate (HR) and breathing frequency (BF) responses during retesting. Methods: Twenty-one cognitively normal older and younger adults (65 ± 2 vs. 26 ± 1 years old) participated in the study. Mini-Mental State Examination (MMSE), Digit-Span-Test (DST), Trail Making Test (TMT-B), and California Verbal Learning Test (CVLT-II) were administered twice at 3-week intervals, while HR and BF were monitored by electrocardiography and plethysmography, respectively. Results: Cognitive performances were not affected by the age factor, and the retest factor only affected CVLT-II. HR and BF increased only in the younger adults ( p < .01) during cognitive tests; retesting attenuated these responses (retest factor p < .01). Long-delay free-recall in CVLT-II was unchanged in cognitively normal older versus younger adults. Healthy aging did not diminish short-term memory assessed by DST and CVLT-II short-delay or long-delay free-recalls. Conclusions: Only CVLT-II, but not MMSE, DST or TMT-B, demonstrated cognitive retesting practice effects in the younger and older adults. Cognitive testing at 3-week intervals in cognitively normal older and younger subjects revealed divergent cardiorespiratory responses to MMSE, DST, and TMT-B cognitive testing, particularly HR, which increased only in younger adults and to a lesser extent during retesting despite the absence of practice effects.
Comparison of Foot Kinematics Between Normal Arch and Flexible Flatfoot Using the Oxford Foot Model: A Matched Case-Control Study
Authors: Vijittrakarnrung Chaiyanun , Mongkolpichayaruk Atipong , Limroongreungrat Weerawat , Chuckpaiwong Bavornrit
Published: February 2024

Background:

Symptomatic flexible flatfoot causes alterations in gait, but exactly how this condition affects the intersegmental motion of the foot during the gait cycle remains unclear. Previous studies have examined the kinematics, yielding inconsistent findings. Therefore, the objective of this study was to investigate how flexible flatfoot deformity, defined as Johnson and Strom classification staging II, affects the intersegmental motion of the foot during fast walking based on a comparison with the matched control group.

Methods:

Eleven participants with symptomatic flexible flatfoot and 11 healthy matched control participants were recruited using a foot screening protocol incorporated through a foot physical examinations and radiographic measurements. All demographic characteristics exhibited comparable profiles between the groups. During controlled walking, kinematic outcomes pertaining to the hallux, hindfoot, forefoot, and tibia were collected using the multisegmental Oxford Foot Model.

Results:

All spatiotemporal parameters were comparable between the groups. In comparison to the control group, individuals with symptomatic flexible flatfoot demonstrated increased hallux valgus and plantarflexion, increased forefoot abduction, heightened hindfoot eversion, and internal rotation. Notably, no significant major differences were observed in the tibia motion segment. Further, significant correlations were identified between static foot measurements and the extent of the maximum deviation observed during dynamic kinematic assessments.

Conclusion:

Compared with age- and gender-matched controls, participants with symptomatic flexible flatfoot exhibited significant gait pattern deviations. A significant correlation also exists between static foot deformity measurements and dynamic kinematic deviations. Collectively, these findings have implications for developing targeted therapeutic interventions to address flexible flatfoot.

Level of evidence:

Level III, diagnostic study.
Analysing India’s Export Competitiveness in ASEAN Economies: Insights from Viner’s Trade Creation Model
Authors: Dawani Chandni , Pareek Deepa
Published: February 2024

Both India and ASEAN are characterised by dynamic market economies and have implemented extensive reforms to deepen their economic integration. Despite the existing economic links between them, this article acknowledges that the trade relations are significant but fall short of their full potential. In this context, the present study utilises a modified trade creation approach to estimate India’s export potential at the sectoral level with individual ASEAN member states for the years 2010 and 2021. The analysis has identified five most significant trading partners in the region, namely, Singapore, Thailand, Malaysia, Vietnam, Indonesia, which together represent substantial trading opportunities in the five broad sectors such as Machinery, Chemical products, Base metals, Plastics, Minerals. Additionally, this article explores ASEAN’s GVC linkages with India vis-à-vis world at an aggregate and sectoral level over the last decade. We base our analysis on the P&C using the UN Broad Economic Category (BEC) product classification, concorded with HS trade classification. The findings reveal a marginal decline in the region’s share of GVC trade with India relative to its global GVC trade.

JEL Classification: F10, F14, F15
Mindful Eco-Wellness: Steps Toward Personal and Planetary Health
Authors: Barrett Bruce , Walters Sarah , Checovich Mary M. , Grabow Maggie L. , Middlecamp Cathy , Wortzel Beth , Tetrault Kaitlin , Riordan Kevin M. , Goldberg Simon
Published: February 2024

Rising greenhouse gas levels heat the earth’s surface and alter climate patterns, posing unprecedented threats to planetary ecology and human health. At the same time, obesity, diabetes, and cardiovascular disease have reached epidemic proportions across the globe, caused in part by decreases in physical activity and by over-consumption of carbon-intensive foods. Thus, interventions that support active transportation (walking or cycling rather than driving) and healthier food choices (eating plant-based rather than meat-based diets) would yield health and sustainability “co-benefits.” Emerging research suggests that mindfulness-based practices might be effective means toward these ends. At the University of Wisconsin-Madison, we have developed a mindfulness-based group program, Mindful Eco-Wellness: Steps Toward Healthier Living. Loosely based on the Mindfulness-Based Stress Reduction course, our curriculum teaches mindfulness practices in tandem with sustainability principles, following weekly themes of Air, Water, Food, Energy, Transportation, Consumption, Nature Experience, and Ethics. For example, the “Air” class offers participants practice in guided breath meditations while they learn about the benefits of clean air. The theme of “Food” is presented through mindful eating, accompanied by educational videos highlighting the consequences of food production and consumption. “Transportation” includes walking/movement meditations and highlights the health benefits of physical activity and detriments of fossil-fueled transportation. Pedagogical lessons on energy, ecological sustainability, and the ethics of planetary health are intertwined with mindful nature experience and metta (loving-kindness) meditation. Curricular materials, including teaching videos, are freely available online. Pilot testing in community settings (n = 30) and in group medical visits (n = 34) has demonstrated feasibility; pilot data suggests potential effectiveness. Rigorous evaluation and testing are needed.
Enricofrancoite, KNaCaSi4O10, a new Ca–K–Na silicate from Somma–Vesuvius volcano, southern Italy
Authors: Balassone Giuseppina , Panikorovskii Taras L. , Pellino Annamaria , Bazai Ayya V. , Bocharov Vladimir N. , Goychuk Olga F. , Avdontseva Evgenia Yu. , Yakovenchuk Victor N. , Krivovichev Sergey V. , Petti Carmela , Cappelletti Piergiulio , Mondillo Nicola , Moliterni Anna , Altomare Angela , Izzo Francesco
Published: February 2024

Enricofrancoite (IMA2023–002), ideally KNaCaSi4O10, is a new litidionite-group member found as the product of high-temperature alteration of hosting silicates with the enrichment by Cu-bearing fluids at the rock–fumaroles interface related to the 1872 eruption of Somma–Vesuvius volcano, southern Italy. It occurs as euhedral and platy crystals or crusts together with litidionite, tridymite, wollastonite and Al- and Fe-bearing diopside, kamenevite, perovskite, rutile, Ti-rich magnetite and colourless Si-glass. Single crystals of enricofrancoite are transparent colourless or light blue with a vitreous lustre. Mohs hardness is 5.5. Dmeas is 2.63(3) g/cm3 and Dcalc is 2.63 g/cm3. The mineral is optically biaxial (−), α = 1.542(5), β = 1.567(5),γ = 1.575(5); 2V(meas) = 60(2)° and 2Vcalc = 58°. The mean chemical composition (wt.%, electron-microprobe data) is: SiO2 64.81, Al2O3 0.03, TiO2 0.08, FeO 0.07, MgO 1.71, CaO 10.64, CuO 2.22, Na2O 8.56, K2O 11.41, total 99.94. The empirical formula based on 10 O apfu is: K0.90Na1.03(Ca0.71Mg0.16Cu0.10)Σ0.97Si4.02O10. The Raman spectrum contains bands at 133, 248, 265, 290, 335, 400, 438, 510, 600, 690 and 1120 cm–1 and the wavenumbers of the IR absorption bands are: 424, 470, 492, 530, 600, 630, 690, 750, 788, 970, 1040 and 1160 cm–1. The eight strongest lines of the powder X-ray diffraction pattern are [d, Å (I, %) hkl]: 6.75 (42) 01$\bar{1}$, 3.65 (20) 11$\bar{2}$, 3.370 (100) 02$\bar{2}$, 3.210 (52) 102, 3.051 (18) 111, 3.033 (25) 2$\bar{1}\bar{2}$, 2.834 (22) 02$\bar{3}$ and 2.411 (72) 03$\bar{2}$. Enricofrancoite is triclinic, space group P$\bar{1}$, unit-cell parameters refined from the single-crystal data are a = 7.0155(4) Å, b = 8.0721(4) Å, c = 10.0275(4) Å, α = 104.420(4)°, β = 99.764(4)°, γ = 115.126(5)° and V = 472.74(5) Å3. The crystal structure has been refined from single-crystal X-ray diffraction data to R1 = 0.035 on the basis of 2078 independent reflections with Fo > 4σ(Fo). Enricofrancoite is an H2O-free analogue of calcinaksite with 5-coordinated Ca2+ at the M site.
ST-LaneNet: Lane Line Detection Method Based on Swin Transformer and LaneNet
Authors: Du Yufeng , Zhang Rongyun , Shi Peicheng , Zhao Linfeng , Zhang Bin , Liu Yaming
Published: February 2024

The advancement of autonomous driving heavily relies on the ability to accurate lane lines detection. As deep learning and computer vision technologies evolve, a variety of deep learning-based methods for lane line detection have been proposed by researchers in the field. However, owing to the simple appearance of lane lines and the lack of distinctive features, it is easy for other objects with similar local appearances to interfere with the process of detecting lane lines. The precision of lane line detection is limited by the unpredictable quantity and diversity of lane lines. To address the aforementioned challenges, we propose a novel deep learning approach for lane line detection. This method leverages the Swin Transformer in conjunction with LaneNet (called ST-LaneNet). The experience results showed that the true positive detection rate can reach 97.53% for easy lanes and 96.83% for difficult lanes (such as scenes with severe occlusion and extreme lighting conditions), which can better accomplish the objective of detecting lane lines. In 1000 detection samples, the average detection accuracy can reach 97.83%, the average inference time per image can reach 17.8 ms, and the average number of frames per second can reach 64.8 Hz. The programming scripts and associated models for this project can be accessed openly at the following GitHub repository: https://github.com/Duane711/Lane-line-detection-ST-LaneNet.
Aluminum enhances the oxidative damage of ZnO NMs in the human neuroblastoma SH-SY5Y cell line
Authors: Jimenez-Chavez Arturo , Pedroza-Herrera Gladis , Betancourt-Reyes Israel , De Vizcaya Ruiz Andrea , Masuoka-Ito David , Zapien Juan Antonio , Medina-Ramirez Iliana E.
Published: February 2024

Bare and doped zinc oxide nanomaterials (ZnO NMs) are of great interest as multifunctional platforms for biomedical applications. In this study, we systematically investigate the physicochemical properties of Aluminum doped ZnO (AZO) and its bio-interactions with neuroblastoma (SH-SY5Y) and red blood (RBCs) cells. We provide a comprehensive chemical and structural characterization of the NMs. We also evaluated the biocompatibility of AZO NMs using traditional toxicity assays and advanced microscopy techniques. The toxicity of AZO NMs towards SH-SY5Y cells, decreases as a function of Al doping but is higher than the toxicity of ZnO NMs. Our results show that N-acetyl cysteine protects SH-SY5Y cells against reactive oxygen species toxicity induced by AZO NMs. ZnO and AZO NMs do not exert hemolysis in human RBCs at the doses that cause toxicity (IC50) in neuroblastoma cells. The Atomic force microscopy qualitative analysis of the interaction of SH-SY5Y cells with AZO NMs shows evidence that the affinity of the materials with the cells results in morphology changes and diminished interactions between neighboring cells. The holotomographic microscopy analysis demonstrates NMs' internalization in SH-SY5Y cells, changes in their chemical composition, and the role of lipid droplets in the clearance of toxicants.

Graphical Abstract
Safety and effcacy of remimazolam tosilate for sedation during combined spinal-epidural anesthesia for orthopedic procedures: a randomized controlled trial
Authors: Chen Yufei , Cai Yimeng , Yu Guoqing , Zhang Xi , Hu Tian , Xue Rui
Published: February 2024

Objective

The objective of this study was to assess the efficacy and safety of Remimazolam in the context of combined spinal-epidural anesthesia for sedation during orthopedic surgery.

Methods

This randomized controlled trial enrolled patients scheduled for orthopedic surgery under combined spinal-epidural anesthesia (N = 80), who were randomly allocated to receive either dexmedetomidine (Group-D) or remimazolam (Group-R). The target sedation range aimed for a Ramsay score of 2–5 or a BIS value of 60–80 to evaluate the effectiveness and safety of remimazolam during sedation.

Results

The time taken to achieve the desired level of sedation was significantly shorter in the remimazolam group compared to the dexmedetomidine group (3.69 ± 0.75 vs. 9.59 ± 1.03; P < 0.0001). Patients in the remimazolam group exhibited quicker recovery, fewer intraoperative adverse events, more consistent vital signs, and greater satisfaction at various time points throughout the surgery.

Conclusion

This preliminary study demonstrates that remimazolam tosilate serves as a safe and effective sedative for orthopedic surgery performed under combined spinal-epidural anesthesia, in comparison with dexmedetomidine.
Macronutrients quality indices and risk of metabolic syndrome and its components in Iranian adults
Authors: Farhadnejad Hossein , Mokhtari Ebrahim , Teymoori Farshad , Jahromi Mitra Kazemi , Saber Niloufar , Ahmadirad Hamid , Norouzzadeh Mostafa , Mirmiran Parvin , Azizi Fereidoun
Published: February 2024

Background/aim

Evidence from recent studies suggested that the quality of dietary macronutrients can play a possible role in predicting the risk of metabolic disorders. In the current study, we aimed to assess the association of carbohydrate quality index (CQI) and protein score with the risk of metabolic syndrome (MetS) in Iranian adults.

Methods

This prospective study was conducted within the framework of the Tehran Lipid and Glucose Study on 1738 individuals aged between 40 and 70 years old, who were followed up for a mean of 6.1 years. A food frequency questionnaire was used to determine CQI and protein scores. The multivariable adjusted Cox regression model was used to calculate the hazard ratio (HR) of MetS across quartiles of protein score and CQI, and its components.

Results

The mean ± standard deviation (SD) age and body mass index of the study population (42.5% men) were 49.3 ± 7.5 years and 27.0 ± 4.0 kg/m2, respectively. Mean ± SD scores of CQI and protein for all participants were 12.6 ± 2.4 and 10.3 ± 3.5, respectively. During the study follow-up, 834(48.0%) new cases of MetS were ascertained. In the multivariable-adjusted model, the risk of MetS was decreased across quartiles of CQI (HR = 0.83;95%CI:0.69–1.00, Ptrend=0.025) and protein score (HR = 0.75; 95% CI:0.60–0.94, Ptrend=0.041). Also, Of CQI components, the whole grain/total grains ratio showed a significant inverse association with the risk of MetS (HR = 0.75;95%CI:0.60–0.94, Ptrend=0.012).

Conclusion

Our findings revealed that a dietary pattern with higher CQI and protein score may be related to a reduced risk of MetS in adults.
Association between the trajectory of ideal cardiovascular health metrics and incident chronic kidney disease among 27,635 older adults in northern China–a prospective cohort study
Authors: Bai Pufei , Shao Xian , Ning Xiaoqun , Jiang Xi , Liu Hongyan , Lin Yao , Hou Fang , Zhang Yourui , Zhou Saijun , Yu Pei
Published: February 2024

Background

There is a lack of relevant studies evaluating the long-term impact of cardiovascular health factor (CVH) metrics on chronic kidney disease (CKD).

Objective

This study investigates the long-term change in CVH metrics in older people and explores the relationship between CVH metrics trajectory and CKD.

Methods

In total, 27,635 older people aged over 60 from the community-based Tianjin Chronic Kidney Disease Cohort study were enrolled. The participants completed five annual physical examinations between January 01, 2014, and December 31, 2018, and a subsequent follow-up between January 01, 2019, and December 31, 2021. CVH metrics trajectories were established by the group-based trajectory model to predict CKD risk. The relationships between baseline CVH, CVH change (ΔCVH), and CKD risk were also explored by logistic regression and restricted cubic spline regression model. In addition, likelihood ratio tests were used to compare the goodness of fit of the different models.

Results

Six distinct CVH metrics trajectories were identified among the participants: low-stable (11.19%), low-medium-stable (30.58%), medium-stable (30.54%), medium-high-decreased (5.46%), medium-high-stable (18.93%), and high-stable (3.25%). After adjustment for potential confounders, higher CVH metrics trajectory was associated with decreased risk of CKD (P for trend < 0.001). Comparing the high-stable with the low-stable group, the risk of CKD decreased by 46%. All sensitivity analyses, including adjusting for baseline CVH and removing each CVH component from the total CVH, produced consistent results. Furthermore, the likelihood ratio test revealed that the model established by the CVH trajectory fit better than the baseline CVH and Δ CVH.

Conclusion

The higher CVH metrics trajectory and improvement of CVH metrics were associated with decreased risk of CKD. This study emphasized the importance of improving CVH to achieve primary prevention of CKD in older people.
How might secondary dementia prevention programs work in practice: a pre-implementation study of the APPLE-Tree program
Authors: Morse Rachel M. , Lang Iain , Rapaport Penny , Poppe Michaela , Morgan-Trimmer Sarah , Cooper Claudia
Published: February 2024

Background

Over 850,000 people in the UK currently have dementia, and that number is expected to grow rapidly. One approach that may help slow or prevent this growth is personalized dementia prevention. For most people, this will involve targeted lifestyle changes. These approaches have shown promise in trials, but as of yet, the evidence for how to scale them to a population level is lacking. In this pre-implementation study, we aimed to explore stakeholder perspectives on developing system-readiness for dementia prevention programs. We focused on the APPLE-Tree program, one of several low-intensity, lifestyle-based dementia prevention interventions currently in clinical trials.

Methods

We conducted semi-structured interviews with health and social care professionals without previous experience with the APPLE-Tree program, who had direct care or managerial experience in services for older adults with memory concerns, without a dementia diagnosis. We used the Consolidated Framework for Implementation Research to guide interviews and thematic analysis.

Results

We interviewed 26 stakeholders: commissioners and service managers (n = 15) and frontline workers (n = 11) from eight NHS and 11 third sector organizations throughout England. We identified three main themes: (1) favorable beliefs in the effectiveness of dementia prevention programs in enhancing cognition and wellbeing and their potential to fill a service gap for people with memory concerns, (2) challenges related to funding and capacity to deliver such programs at organizations without staff capacity or higher prioritization of dementia services, and (3) modifications to delivery and guidance required for compatibility with organizations and patients.

Conclusion

This study highlights likely challenges in scale-up if we are to make personalized dementia prevention widely available. This will only be possible with increased funding of dementia prevention activities; integrated care systems, with their focus on prevention, may enable this. Scale-up of dementia prevention programs will also require clear outlines of their core and adaptable components to fit funding, patient, and facilitator needs.
Cognitive frailty and its association with disability among Chinese community-dwelling older adults: a cross-sectional study
Authors: Kong Ling-lin , Xie Wen , Dong Zi-yan , Liu Yue-ting , Zhao Hui-Min , Fan Jun-Yao , Qi Xiao-jing , Li Jie
Published: February 2024

Background

There are a variety of determinants that are key to functional disability of older adults. However, little is known regarding the relationship between cognitive frailty and disability among older people. The aims of this study were to examine the associations between cognitive frailty and its six components with instrumental activities of daily living (IADL) functioning in community-dwelling older adults.

Methods

A total of 313 community-dwelling older adults (aged ≥ 65 years) were recruited from eight community centers in central China. Cognitive frailty was operationalized using the Mini-Mental State Examination for the evaluation of cognitive status and the Fried criteria for the evaluation of physical frailty. The outcome was functional disability assessed by the IADL scale. The association between cognitive frailty, as well as its components, and IADL limitations was identified by conducting binary logistic regression analysis.

Results

The prevalence of cognitive frailty was 8.9% in this study. The results showed that cognitive frailty (OR = 22.86) and frailty without cognitive impairment (OR = 8.15) were associated with IADL limitations. Subdimensions of cognitive frailty, exhaustion, weakness, low physical activity and cognitive impairment components were independently associated with IADL limitations.

Conclusion

Cognitive frailty was associated with a higher prevalence of disability. Interventions for improving cognitive frailty should be developed to prevent IADL disability among community-dwelling older adults in China.
Respiratory syncytial virus subtypes in children with bronchiolitis: does it correlate with clinical severity?
Authors: Yang Shuo , Lu Sukun , Wang Yakun , Guo Yinghui , Zhang Zhuang , Wang Weijian , Wang Le
Published: February 2024

Background

In this retrospective study, we aimed to evaluate the factors associated with the severity of respiratory syncytial virus (RSV) bronchiolitis in children aged under 2 years who were admitted to the Children’s Hospital of Hebei between June 2018 and January 2019.

Methods

Sputum samples positive for RSV via multiplex PCR were subtyped using real-time PCR. Data collected included risk factors for disease severity, demographics, microbiology, and outcomes.

Results

Of the 82 children with RSV bronchiolitis, 79 were treated and discharged with improvement, while 3 died. All three patients had underlying medical conditions, including complex congenital heart disease and severe combined immunodeficiency. Further, disease severity was associated with preexisting underlying disease, fever duration, and bacterial co-infection, but not with the RSV subtype.

Conclusions

Our findings suggest that an appropriate therapeutic regimen should include the detection of bacterial co-infections and the identification of underlying diseases for the effective management of severe RSV bronchiolitis.
Patterns of Chlamydia trachomatis and Neisseria gonorrhoeae in different anatomical sites among Pre-Exposure Prophylaxis (PrEP) users in Brazil
Authors: Antonini Marcela , Vettore Mario Vianna , Øgård-Repål Anita , de Macêdo Rocha Daniel , de Alencar Rocha Karyanna Alves , Elias Henrique Ciabotti , Barufaldi Felipe , Santana Rodrigo Carvalho , Gir Elucir , Spire Bruno , Reis Renata Karina
Published: February 2024

Background

The presence of untreated sexually transmitted infections (STIs) significantly increases the chance of acquiring HIV. In Brazil, testing for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) among Pre-Exposure Prophylaxis (PrEP) users is insufficient, and syndromic treatment is a priority in clinical practice. Multi-site testing for CT/NG improves thescreening of asymptomatic cases and ensures timely treatment. Therefore, it is essential for HIV prevention. This study aims to test the importance of two-site testing for better screening of these pathogens and to determine whether the presence of symptoms is an indicator of CT/NG infection.

Methods

This is a cross-sectional study carried out in four public infectious diseases clinics in São Paulo State, Brazil between January of 2022 and March of 2023. All participants had an anal swab and a first-pass or mid-stream urine collected for CT/NG analysis by Polymerase chain reaction (PCR). Data about sociodemographic, sexual behavioural and clinical aspects were collected. Pathway analysis was used to examine the direct and indirect relationships between variables according to the theoretical model.

Results

We screened 171 PrEP users which had two samples collected, resulting in 342 samples. Comparing the anatomic sites, the urine samples showed lower sensitivity for CT and NG than anal samples. Gonorrhoea was directly linked to lower age (β= -0.161, p = 0.001). Time of PrEP use was directly associated with CT infection (β = 0.202; p = 0.042) and inversely associated with dysuria (β= -0.121, p = 0.009). Lower occurrence of yellow-green secretion was linked to detection of CT (β= -0.089, p = 0.005) and NG (β= -0.048, p = 0.002) infections. Foul-smelling discharge was directly associated with CT (β = 0.275, p = 0.004) and NG (β = 0.295, p = 0.037) infection.

Conclusion

The symptoms are a bad indicator of CT and NG infection, and the screening must be done in more than one site since most of the positive results would be missed if only urines were tested. In the case of testing only one anatomical site, specifically the urethra, the CT/NG incidence and prevalence would be underestimated. The two-sites testing improves detection rates of CT/NG, and PrEP follow-up benefits people offering STI testing.