bluuebunny/crossref_metadata_2025 huggingface dataset:
Emerging Role of Purine Metabolizing Enzymes in Brain Function and Tumors
Authors: Garcia-Gil Mercedes , Camici Marcella , Allegrini Simone , Pesi Rossana , Petrotto Edoardo , Tozzi Maria Grazia
Published: November 2018

The growing evidence of the involvement of purine compounds in signaling, of nucleotide imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light on purine metabolism, indicating that well known biochemical pathways may still surprise. Adenosine deaminase is important not only to preserve functionality of immune system but also to ensure a correct development and function of central nervous system, probably because its activity regulates the extracellular concentration of adenosine and therefore its function in brain. A lot of work has been done on extracellular 5′-nucleotidase and its involvement in the purinergic signaling, but also intracellular nucleotidases, which regulate the purine nucleotide homeostasis, play unexpected roles, not only in tumorigenesis but also in brain function. Hypoxanthine guanine phosphoribosyl transferase (HPRT) appears to have a role in the purinosome formation and, therefore, in the regulation of purine synthesis rate during cell cycle with implications in brain development and tumors. The final product of purine catabolism, uric acid, also plays a recently highlighted novel role. In this review, we discuss the molecular mechanisms underlying the pathological manifestations of purine dysmetabolisms, focusing on the newly described/hypothesized roles of cytosolic 5′-nucleotidase II, adenosine kinase, adenosine deaminase, HPRT, and xanthine oxidase.
Gadolinium Chloride Rescues Niemann–Pick Type C Liver Damage
Authors: Klein Andrés D. , Oyarzún Juan Esteban , Cortez Cristian , Zanlungo Silvana
Published: November 2018

Niemann–Pick type C (NPC) disease is a rare neurovisceral cholesterol storage disorder that arises from loss of function mutations in the NPC1 or NPC2 genes. Soon after birth, some patients present with an aggressive hepatosplenomegaly and cholestatic signs. Histopathologically, the liver presents with large numbers of foam cells; however, their role in disease pathogenesis has not been explored in depth. Here, we studied the consequences of gadolinium chloride (GdCl3) treatment, a well-known Kupffer/foam cell inhibitor, at late stages of NPC liver disease and compared it with NPC1 genetic rescue in hepatocytes in vivo. GdCl3 treatment successfully blocked the endocytic capacity of hepatic Kupffer/foam measured by India ink endocytosis, decreased the levels CD68—A marker of Kupffer cells in the liver—and normalized the transaminase levels in serum of NPC mice to a similar extent to those obtained by genetic Npc1 rescue of liver cells. Gadolinium salts are widely used as magnetic resonance imaging (MRI) contrasts. This study opens the possibility of targeting foam cells with gadolinium or by other means for improving NPC liver disease. Synopsis: Gadolinium chloride can effectively rescue some parameters of liver dysfunction in NPC mice and its potential use in patients should be carefully evaluated.
Newborn Screening for Sickle Cell Disease: Indian Experience
Authors: Colah Roshan B. , Mehta Pallavi , Mukherjee Malay B.
Published: November 2018

Sickle cell disease (SCD) is a major public health problem in India with the highest prevalence amongst the tribal and some non-tribal ethnic groups. The clinical manifestations are extremely variable ranging from a severe to mild or asymptomatic condition. Early diagnosis and providing care is critical in SCD because of the possibility of lethal complications in early infancy in pre-symptomatic children. Since 2010, neonatal screening programs for SCD have been initiated in a few states of India. A total of 18,003 babies have been screened by automated HPLC using either cord blood samples or heel prick dried blood spots and 2944 and 300 babies were diagnosed as sickle cell carriers and SCD respectively. A follow up of the SCD babies showed considerable variation in the clinical presentation in different population groups, the disease being more severe among non-tribal babies. Around 30% of babies developed serious complications within the first 2 to 2.6 years of life. These pilot studies have demonstrated the feasibility of undertaking newborn screening programs for SCD even in rural areas. A longer follow up of these babies is required and it is important to establish a national newborn screening program for SCD in all of the states where the frequency of the sickle cell gene is very high followed by the development of comprehensive care centers along with counselling and treatment facilities. This comprehensive data will ultimately help us to understand the natural history of SCD in India and also help the Government to formulate strategies for the management and prevention of sickle cell disease in India.
The Memory of the Heart
Authors: Cirillo Marco
Published: November 2018

The embryological development of the heart is one of the most fascinating phenomena in nature and so is its final structure and function. The various ontogenetic passages form the evolutive basis of the final configuration of the heart. Each key step can be recognized in the final features, as the heart maintains a kind of “memory” of these passages. We can identify the major lines of development of the heart and trace these lines up to the mature organ. The aim of this review is to identify these key parameters of cardiac structure and function as essential elements of the heart’s proper functioning and bases for its treatment. We aim to track key steps of heart development to identify what it “remembers” and maintains in its final form as positively selected. A new vision based on the whole acquired knowledge must guide an in-depth scientific approach in future papers and guidelines on the topic and a complete, farsighted therapeutic conduct able to ensure the physiological correction of cardiac pathologies. The application of this modern, functional vision of the heart could improve the clinical treatment of heart disease, filling the gaps still present.
Comparison of College Students’ Energy Expenditure, Physical Activity, and Enjoyment during Exergaming and Traditional Exercise
Authors: McDonough Daniel , Pope Zachary , Zeng Nan , Lee Jung , Gao Zan
Published: November 2018

This study evaluated the effects of exergaming on college students’ energy expenditure (EE), moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), rating of perceived exertion (RPE), and enjoyment compared to traditional treadmill exercise, and sex differences. Sixty college students (30 female; X ¯ age = 23.6 ± 4.1 years) completed three 20-min exercise sessions on Xbox 360 Kinect Just Dance (Microsoft, Redmond, WA, USA), Xbox 360 Kinect Reflex Ridge (Microsoft, Redmond, WA, USA), and treadmill walking. Their EE and PA were assessed by ActiGraph accelerometers (ActiGraph Co.; Pensacola, FL, USA); RPE every four min; enjoyment via an established scale. Significant exercise-type by sex interaction effects were observed for RPE (p < 0.01): females reported significantly lower RPE during exergaming sessions but significantly higher RPE during treadmill walking. Results revealed significant main effects for all outcomes between exercise sessions (all p < 0.01): treadmill walking resulted in significantly higher metabolic equivalents (METs), MVPA, and EE (p < 0 .01), yet lower LPA (p < 0.01), compared to the two exergaming sessions. Participants’ RPE was significantly higher during treadmill walking than during exergaming sessions, with exergaming eliciting significantly higher enjoyment (all p < 0.01). College students find exergaming more enjoyable and report lower RPE compared to traditional treadmill exercise, though not yet matching the moderate physiological intensity level.
Serum Renalase Levels Are Predicted by Brain-Derived Neurotrophic Factor and Associated with Cardiovascular Events and Mortality after Percutaneous Coronary Intervention
Authors: Lee I-Te , Sheu Wayne Huey-Herng
Published: November 2018

Circulating brain-derived neurotrophic factor (BDNF) predicts survival rate in patients with coronary artery disease (CAD). We examined the relationship between BDNF and renalase before and after percutaneous coronary intervention (PCI) and the role of renalase in patients with CAD. Serum BDNF and renalase levels were determined using blood samples collected before and after PCI. Incident myocardial infarction, stroke, and mortality were followed up longitudinally. A total of 152 patients completed the assessment. BDNF levels were not significantly changed after PCI compared to baseline levels (24.7 ± 11.0 vs. 23.5 ± 8.3 ng/mL, p = 0.175), although renalase levels were significantly reduced (47.5 ± 17.3 vs. 35.9 ± 11.3 ng/mL, p < 0.001). BDNF level before PCI was an independent predictor of reduction in renalase (95% confidence interval (CI): −1.371 to −0.319). During a median 4.1 years of follow-up, patients with serum renalase levels of ≥35 ng/mL had a higher risk of myocardial infarction, stroke, and death than those with renalase of <35 ng/mL (hazard ratio = 5.636, 95% CI: 1.444–21.998). In conclusion, our results show that serum BDNF levels before PCI were inversely correlated with the percentage change in renalase levels after PCI. Nevertheless, post-PCI renalase level was a strong predictor for myocardial infarction, stroke, and death.
Non-Hepatic Alkaline Phosphatase, hs-CRP and Progression of Vertebral Fracture in Patients with Rheumatoid Arthritis: A Population-Based Longitudinal Study
Authors: Yeh Jih-Chen , Wu Chang-Chin , Choy Cheuk-Sing , Chang Shu-Wei , Liou Jian-Chiun , Chen Kuo-Shu , Tung Tao-Hsin , Lin Wei-Ning , Hsieh Chih-Yu , Ho Chun-Ta , Wang Ting-Ming , Chang Jia-Feng
Published: November 2018

Background: Interactions and early warning effects of non-hepatic alkaline phosphatase (NHALP) and high-sensitivity C-reactive protein (hs-CRP) on the progression of vertebral fractures (VFs) in patients with rheumatoid arthritis (RA) remain unclear. We aim to explore whether serum concentrations of NHALP and hs-CRP could serve as a promising dual biomarker for prognostic assessment of VF progression. Methods: Unadjusted and adjusted hazard ratios (aHRs) of VF progression were calculated for different categories of serum NHALP and hs-CRP using the Cox regression model in RA patients. The modification effect between serum NHALP and hs-CRP on VF progression was determined using an interaction product term. Results: During 4489 person-years of follow-up, higher NHALP (>125 U/L) and hs-CRP (>3.0 mg/L) were robustly associated with incremental risks of VF progression in RA patients (aHR: 2.2 (95% confidence intervals (CIs): 1.2–3.9) and 2.0 (95% CI: 1.3–3.3) compared to the lowest HR category, respectively). The interaction between NHALP and hs-CRP on VF progression was statistically significant (p < 0.05). In the stratified analysis, patients with combined highest NHALP and hs-CRP had the greatest risk of VF progression (aHR: 4.9 (95% CI: 2.5–9.6)) compared to the lowest HR group (NHALP < 90 U/L and hs-CRP < 1 mg/L). Conclusions: In light of underdiagnoses of VFs and misleading diagnosis by single test, NHALP and hs-CRP could serve as compensatory biomarkers to predict subclinical VF progression in RA patients.
An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets
Authors: Lu Wan Jung , Chung Chi Li , Chen Ray Jade , Huang Li Ting , Lien Li Ming , Chang Chao Chien , Lin Kuan Hung , Sheu Joen Rong
Published: November 2018

Phospholipase D (PLD) is involved in many biological processes. PLD1 plays a crucial role in regulating the platelet activity of mice; however, the role of PLD in the platelet activation of humans remains unclear. Therefore, we investigated whether PLD is involved in the platelet activation of humans. Our data revealed that inhibition of PLD1 or PLD2 using pharmacological inhibitors effectively inhibits platelet aggregation in humans. However, previous studies have showed that PLD1 or PLD2 deletion did not affect mouse platelet aggregation in vitro, whereas only PLD1 deletion inhibited thrombus formation in vivo. Intriguingly, our data also showed that the pharmacological inhibition of PLD1 or PLD2 does not affect mouse platelet aggregation in vitro, whereas the inhibition of only PLD1 delayed thrombus formation in vivo. These findings indicate that PLD may play differential roles in humans and mice. In humans, PLD inhibition attenuates platelet activation, adhesion, spreading, and clot retraction. For the first time, we demonstrated that PLD1 and PLD2 are essential for platelet activation in humans, and PLD plays different roles in platelet function in humans and mice. Our findings also indicate that targeting PLD may provide a safe and alternative therapeutic approach for preventing thromboembolic disorders.
A Recent Progress of Spintronics Devices for Integrated Circuit Applications
Authors: Endoh Tetsuo , Honjo Hiroaki
Published: November 2018

Nonvolatile (NV) memory is a key element for future high-performance and low-power microelectronics. Among the proposed NV memories, spintronics-based ones are particularly attractive for applications, owing to their low-voltage and high-speed operation capability in addition to their high-endurance feature. There are three types of spintronics devices with different writing schemes: spin-transfer torque (STT), spin-orbit torque (SOT), and electric field (E-field) effect on magnetic anisotropy. The NV memories using STT have been studied and developed most actively and are about to enter into the market by major semiconductor foundry companies. On the other hand, a development of the NV memories using other writing schemes are now underway. In this review article, first, the recent advancement of the spintronics device using STT and the NV memories using them are reviewed. Next, spintronics devices using the other two writing schemes (SOT and E-field) are briefly reviewed, including issues to be addressed for the NV memories application.
Real-Time Chronological Hazard Impact Modeling
Authors: Stempel Peter , Ginis Isaac , Ullman David , Becker Austin , Witkop Robert
Published: November 2018

The potential of using ADvanced CIRCulation model (ADCIRC) to assess the time incremented progression of hazard impacts on individual critical facilities has long been recognized but is not well described. As ADCIRC is applied to create granular impact models, the lack of transparency in the methods is problematic. It becomes difficult to evaluate the entire system in situations where modeling integrates different types of data (e.g., hydrodynamic and existing geospatial point data) and involves multiple disciplines and stakeholders. When considering increased interest in combining hydrodynamic models, existing geospatial information, and advanced visualizations it is necessary to increase transparency and identify the pitfalls that arise out of this integration (e.g., the inadequacy of data to support the resolution of proposed outputs). This paper thus describes an all numerical method to accomplish this integration. It provides an overview of the generation of the hydrodynamic model, describes the all numerical method utilized to model hazard impacts, identifies pitfalls that arise from the integration of existing geospatial data with the hydrodynamic model, and describes an approach to developing a credible basis for determining impacts at a granular scale. The paper concludes by reflecting on the implementation of these methods as part of a Federal Emergency Management Agency (FEMA) Integrated Emergency Management Training Course (IEMC) and identifies the need to further study the effects of integrated models and visualizations on risk perception.
The Impact of Potassium Channel Gene Polymorphisms on Antiepileptic Drug Responsiveness in Arab Patients with Epilepsy
Authors: AL-Eitan Laith N. , Al-Dalalah Islam M. , Elshammari Afrah K. , Khreisat Wael H. , Almasri Ayah Y.
Published: November 2018

This study aims to investigate the effects of the three potassium channel genes KCNA1, KCNA2, and KCNV2 on increased susceptibility to epilepsy as well as on responsiveness to antiepileptic drugs (AEDs). The pharmacogenetic and case-control cohort (n = 595) consisted of 296 epileptic patients and 299 healthy individuals. Epileptic patients were recruited from the Pediatric Neurology clinic at the Queen Rania Al Abdullah Hospital (QRAH) in Amman, Jordan. A custom platform array search for genetic association in Jordanian-Arab epileptic patients was undertaken. The MassARRAY system (iPLEX GOLD) was used to genotype seven single nucleotide polymorphisms (SNPs) within three candidate genes (KCNA1, KCNA2, and KCNV2). Only one SNP in KCNA2, rs3887820, showed significant association with increased risk of susceptibility to generalized myoclonic seizure (p-value < 0.001). Notably, the rs112561866 polymorphism of the KCNA1 gene was non-polymorphic, but no significant association was found between the KCNA1 (rs2227910, rs112561866, and rs7974459) and KCNV2 (rs7029012, rs10967705, and rs10967728) polymorphisms and disease susceptibility or drug responsiveness among Jordanian patients. This study suggests that a significant association exists between the KCNA2 SNP rs3887820 and increased susceptibility to generalized myoclonic seizure. However, the present findings indicate that the KCNA1 and KCNV2 SNPs do not influence disease susceptibility and drug responsiveness in epileptic patients. Pharmacogenetic and case-control studies involving a multicenter and multiethnic approach are needed to confirm our results. To improve the efficacy and safety of epilepsy treatment, further studies are required to identify other genetic factors that contribute to susceptibility and treatment outcome.
Environmental Justice in Accessibility to Green Infrastructure in Two European Cities
Authors: De Sousa Silva Catarina , Viegas Inês , Panagopoulos Τhomas , Bell Simon
Published: November 2018

Although it is well-established that urban green infrastructure is essential to improve the population’s wellbeing, in many developed countries, the availability of green spaces is limited or its distribution around the city is uneven. Some minority groups may have less access or are deprived of access to green spaces when compared with the rest of the population. The availability of public green spaces may also be directly related to the geographical location of the city within Europe. In addition, current planning for urban regeneration and the creation of new high-quality recreational public green spaces sometimes results in projects that reinforce the paradox of green gentrification. The aim of this study was to explore the concept of environmental justice in the distribution of the public green spaces in two contrasting cities, Tartu, Estonia; and Faro, Portugal. Quantitative indicators of public green space were calculated in districts in each city. The accessibility of those spaces was measured using the “walkability” distance and grid methods. The results revealed that there was more availability and accessibility to public green spaces in Tartu than in Faro. However, inequalities were observed in Soviet-era housing block districts in Tartu, where most of the Russian minority live, while Roma communities in Faro were located in districts without access to public green space. The availability of public green spaces varied from 1.22 to 31.44 m2/inhabitant in the districts of Faro, and 1.04 to 164.07 m2/inhabitant in the districts of Tartu. In both cities, 45% of the inhabitants had accessible public green spaces within 500 m of their residence. The development of targeted new green infrastructure could increase access to 88% of the population for the city of Faro and 86% for Tartu, delivering environmental justice without provoking green gentrification. The outcome of this study provides advice to urban planners on how to balance green space distribution within city neighbourhoods.
Effect of Shaft Surface Roughness on the Performance of Radial Lip Seals
Authors: Kozuch Emilia , Nomikos Petros , Rahmani Ramin , Morris Nick , Rahnejat Homer
Published: November 2018

Reduction of leakage from the shaft–radial lip seal conjunction is critical in ensuring enduring performance of entire lubrication system. This paper investigates leakage from three types of shaft surfaces, finished using different manufacturing processes. The measurement of surface topography is conducted in order to determine the pertinent roughness parameters which correspond to the observed sealing performance in real practical applications. It is found that the skewness of the surface topography correlates well with the anecdotal leakage failure rate. To quantify this association, a hydrodynamic model, accounting for shaft roughness in a deterministic manner is developed. The results from the numerical analyses confirm that the lubricant mass flow rate is reduced in the case of negatively skewed surface height distributions, when compared with the positively skewed profiles.
Detrimental Effects of Doping Al and Ba on the Thermoelectric Performance of GeTe
Authors: Srinivasan Bhuvanesh , Gellé Alain , Halet Jean-François , Boussard-Pledel Catherine , Bureau Bruno
Published: November 2018

GeTe-based materials are emerging as viable alternatives to toxic PbTe-based thermoelectric materials. In order to evaluate the suitability of Al as dopant in thermoelectric GeTe, a systematic study of thermoelectric properties of Ge1−xAlxTe (x = 0–0.08) alloys processed by Spark Plasma Sintering are presented here. Being isoelectronic to Ge1−xInxTe and Ge1−xGaxTe, which were reported with improved thermoelectric performances in the past, the Ge1−xAlxTe system is particularly focused (studied both experimentally and theoretically). Our results indicate that doping of Al to GeTe causes multiple effects: (i) increase in p-type charge carrier concentration; (ii) decrease in carrier mobility; (iii) reduction in thermopower and power factor; and (iv) suppression of thermal conductivity only at room temperature and not much significant change at higher temperature. First principles calculations reveal that Al-doping increases the energy separation between the two valence bands (loss of band convergence) in GeTe. These factors contribute for Ge1−xAlxTe to exhibit a reduced thermoelectric figure of merit, unlike its In and Ga congeners. Additionally, divalent Ba-doping [Ge1−xBaxTe (x = 0–0.06)] is also studied.
Electrochemical Comparison of SAN/PANI/FLG and ZnO/GO Coated Cast Iron Subject to Corrosive Environments
Authors: Ahmed Muhammad Khitab , Shahid Muhammad , Khan Zulfiqar Ahmad , Ammar Ameen Uddin , Saboor Abdul , Khalid Amir , Hayat Asad , Saeed Adil , Koohgilani Mehran
Published: November 2018

ZnO/GO (Graphene Oxide) and SAN (Styrene Acrylonitrile)/PANI (Polyaniline)/FLG (Few Layers Graphene) nanocomposite coatings were produced by solution casting and sol-gel methods, respectively, to enhance corrosion resistance of ferrous based materials. Corrosive seawater and ‘produced crude oil water’ environments were selected as electrolytes for this study. Impedance and coating capacitance values obtained from Electrochemical Impedance Spectroscopy (EIS) Alternating Current (AC technique) showed enhanced corrosion resistance of nanocomposites coatings in the corrosive environments. Tafel scan Direct Current (DC technique) was used to find the corrosion rate of nanocomposite coating. SAN/PANI/FLG coating reduced the corrosion of bare metal up to 90% in seawater whereas ZnO/GO suppressed the corrosion up to 75% having the impedance value of 100 Ω. In produced water of crude oil, SAN/PANI/FLG reduced the corrosion up to 95% while ZnO/GO suppressed the corrosion up to 10%. Hybrid composites of SAN/PANI/FLG coatings have demonstrated better performances compared to ZnO/GO in the corrosive environments under investigation. This study provides fabrication of state-of-the-art novel anti corrosive nanocomposite coatings for a wide range of industrial applications. Reduced corrosion will result in increased service lifetime, durability and reliability of components and system and will in turn lead to significant cost savings.
Long-Term Influence of Laser-Processing Parameters on (Super)hydrophobicity Development and Stability of Stainless-Steel Surfaces
Authors: Gregorčič Peter , Conradi Marjetka , Hribar Luka , Hočevar Matej
Published: November 2018

Controlling the surface wettability represents an important challenge in the field of surface functionalization. Here, the wettability of a stainless-steel surface is modified by 30-ns pulses of a Nd:YAG marking laser (λ = 1064 nm) with peak fluences within the range 3.3–25.1 J cm−2. The short- (40 days), intermediate- (100 days) and long-term (1 year) superhydrophilic-to-(super)hydrophobic transition of the laser-textured surfaces exposed to the atmospheric air is examined by evaluating its wettability in the context of the following parameters: (i) pulse fluence; (ii) scan line separation; (iii) focal position and (iv) wetting period due to contact angle measurements. The results show that using solely a short-term evaluation can lead to wrong conclusions and that the faster development of the hydrophobicity immediately after laser texturing usually leads to lower final contact angle and vice versa, the slower this transition is, the more superhydrophobic the surface is expected to become (possibly even with self-cleaning ability). Depending on laser fluence, the laser-textured surfaces can develop stable or unstable hydrophobicity. Stable hydrophobicity is achieved, if the threshold fluence of 12 J cm−2 is exceeded. We show that by nanosecond-laser texturing a lotus-leaf-like surface with a contact angle above 150° and roll-off angle below 5° can be achieved.
Preparation of Renewable Bio-Polyols from Two Species of Colliguaja for Rigid Polyurethane Foams
Authors: Abril-Milán Diana , Valdés Oscar , Mirabal-Gallardo Yaneris , F. de la Torre Alexander , Bustamante Carlos , Contreras Jorge
Published: November 2018

In this study, we investigated the potential of two non-edible oil extracts from seeds of Colliguaja integerrima (CIO) and Colliguaja salicifolia (CSO) to use as a renewable source for polyols and, eventually, polyurethane foams or biodiesel. For this purpose, two novel polyols from the aforementioned oils were obtained in a one-single step reaction using a mixture of hydrogen peroxide and acetic acid. The polyol derivatives obtained from the two studied oils were characterized by spectral (FTIR, 1H NMR, and 13C NMR), physicochemical (e.g., chromatographic analysis, acid value, oxidizability values, iodine value, peroxide value, saponification number, kinematic viscosity, density, theorical molecular weight, hydroxyl number, and hydroxyl functionality) and thermal (TGA) analyses according to standard methods. Physicochemical results revealed that all parameters, with the exception of the iodine value, were higher for bio-polyols (CSP and CIP) compared to the starting oils. The NMR, TGA, and FTIR analyses demonstrated the formation of polyols. Finally, the OH functionality values for CIP and CSP were 4.50 and 5.00, respectively. This result indicated the possible used of CIP and CSP as a raw material for the preparation of polyurethane rigid foams.
Enhanced Ferroelectric and Piezoelectric Properties of (1−x)PMN-xPT Ceramics Based on a Partial Oxalate Process
Authors: Kim Jinhwan , Yoon Sanghyun , Ji Jae-Hoon , Ko Young-Ho , Cho Kyung-Ho , Lee Sang-Kwon , Koh Jung-Hyuk
Published: November 2018

The pyrochlore phase in ferroelectric and piezoelectric materials is the main obstacle device application due to its poor electrical properties. Especially, the pyrochlore phase is frequently observed in the perovskite-based metal-oxide materials including piezoelectric and ferroelectric ceramics, which are based on solid-state reaction methods for fabrication. To overcome these problems, advanced innovative methods such as partial oxalate process will be investigated. In this method, crystalized magnesium niobite (MN) and lead titanate (PT) powders will be coated with a certain amount of lead oxalate and, then, the calcination process can be carried out to form the PMN-PT without pyrochlore phase. In this study, (1−x)PMN-xPT ceramics near the morphotropic phase boundary (MPB), with compositions of x = 0.25–0.40, have been prepared employing the partial oxalate method at various temperatures. The crystalline, microstructure, and piezoelectric properties of (1−x)PMN-xPT ceramics depending on the sintering temperature were intensively investigated and discussed. By optimizing the sintering temperature and compositions from the PMN-PT ceramics, the maximum value of the piezoelectric charge coefficient (d33) of 665pC/N, planar electromechanical coupling factor (kp) of 77.8%, dielectric constant (εr) of 3230, and remanent polarization (Pr) of 31.67 μC/cm2 were obtained.
Electrolytic Surface Treatment for Improved Adhesion between Carbon Fibre and Polycarbonate
Authors: Kamps Jan Henk , Henderson Luke C. , Scheffler Christina , Van der Heijden Ruud , Simon Frank , Bonizzi Teena , Verghese Nikhil
Published: November 2018

To achieve good mechanical properties of carbon fibre-reinforced polycarbonate composites, the fibre-matrix adhesion must be dialled to an optimum level. The electrolytic surface treatment of carbon fibres during their production is one of the possible means of adapting the surface characteristics of the fibres. The production of a range of tailored fibres with varying surface treatments (adjusting the current, potential, and conductivity) was followed by contact angle, inverse gas chromatography and X-ray photoelectron spectroscopy measurements, which revealed a significant increase in polarity and hydroxyl, carboxyl, and nitrile groups on the fibre surface. Accordingly, an increase in the fibre-matrix interaction indicated by a higher interfacial shear strength was observed with the single fibre pull-out force-displacement curves. The statistical analysis identified the correlation between the process settings, fibre surface characteristics, and the performance of the fibres during single fibre pull-out testing.
Rapid Solar-Light Driven Superior Photocatalytic Degradation of Methylene Blue Using MoS2-ZnO Heterostructure Nanorods Photocatalyst
Authors: Ritika  , Kaur Manjot , Umar Ahmad , Mehta Surinder Kumar , Singh Surinder , Kansal Sushil Kumar , Fouad H. , Alothman Othman Y.
Published: November 2018

Herein, MoS2-ZnO heterostructure nanorods were hydrothermally synthesized and characterized in detail using several compositional, optical, and morphological techniques. The comprehensive characterizations show that the synthesized MoS2/ZnO heterostructure nanorods were composed of wurtzite hexagonal phase of ZnO and rhombohedral phase of MoS2. The synthesized MoS2/ZnO heterostructure nanorods were used as a potent photocatalyst for the decomposition of methylene blue (MB) dye under natural sunlight. The prepared MoS2/ZnO heterostructure nanorods exhibited ~97% removal of MB in the reaction time of 20 min with the catalyst amount of 0.15 g/L. The kinetic study revealed that the photocatalytic removal of MB was found to be in accordance with pseudo first-order reaction kinetics with an obtained rate constant of 0.16262 min−1. The tremendous photocatalytic performance of MoS2-ZnO heterostructure nanorods could be accredited to an effective charge transportation and inhibition in the recombination of photo-excited charge carriers at an interfacial heterojunction. The contribution of active species towards the decomposition of MB using MoS2-ZnO heterostructure nanorods was confirmed from scavenger study and terephthalic acid fluorescence technique.
Morphological, Rheological and Electromagnetic Properties of Nanocarbon/Poly(lactic) Acid for 3D Printing: Solution Blending vs. Melt Mixing
Authors: Spinelli Giovanni , Lamberti Patrizia , Tucci Vincenzo , Kotsilkova Rumiana , Tabakova Sonia , Ivanova Radost , Angelova Polya , Angelov Verislav , Ivanov Evgeni , Di Maio Rosa , Silvestre Clara , Meisak Darya , Paddubskaya Alesia , Kuzhir Polina
Published: November 2018

The limitation of poor mechanical stability and difficulties in printing electrically conductive components can be overcome owing to the recent introduction of nanotechnology into the field of additive manufacturing (AM) and the consequent development of nonconventional polymer nanocomposites suitable for 3D printing. In the present work, different weight percentages (up to 6 wt % in total) of carbon-based nanostructures—multiwalled carbon nanotubes (MWCNTs), graphene nanoplatelets (GNPs), and a combination of both fillers (MWCNTs/GNPs)—were incorporated into poly(lactic) acid (PLA, Ingeo™) in an attempt to overcome several limitations of conventional 3D manufacturing based on insulating materials. Solution blending and melt mixing were the two fabrication methods adopted for preparation of the samples under test. A comparison of the morphological, rheological, and electrical properties of the resulting nanocomposites was carried out. Moreover, for the same weight concentrations, the influence of physical and geometrical features (i.e., functionalization and aspect ratio) of the embedded fillers was also investigated. Rheological methods were applied to control the quality of fillers dispersion in PLA matrix. The rheological percolation threshold was considered as reference in order to evaluate the internal structure of nanodispersions. TEM visualization, combined with rheological characterizations, was used for efficient control of the nanofiller dispersion. DC characterization revealed that lower electrical percolation thresholds and higher values of electrical conductivity were achieved using fillers with a larger aspect ratio and melt mixing, respectively. Moreover, given the possibility of obtaining complex and appropriate shapes for electromagnetic compatibility (EC) applications, electromagnetic (EM) response of the nanocomposites at the highest filler concentration was investigated in GHz and THz regions. It was found that the electromagnetic shielding efficiency (EMI) of nanocomposites strongly depended on the aspect ratio of the nanofillers, whereas the type of processing technique did not have a significant effect. Therefore, a careful choice of methods and materials must be made to address the final application for which these materials and further 3D printed architectures are designed.
Thermal and Mechanical Properties of Silica–Lignin/Polylactide Composites Subjected to Biodegradation
Authors: Grząbka-Zasadzińska Aleksandra , Klapiszewski Łukasz , Borysiak Sławomir , Jesionowski Teofil
Published: November 2018

In this paper, silica–lignin hybrid materials were used as fillers for a polylactide (PLA) matrix. In order to simulate biodegradation, PLA/hybrid filler composite films were kept in soil of neutral pH for six months. Differential scanning calorimetry (DSC) allowed analysis of nonisothermal crystallization behavior of composites, thermal analysis provided information about their thermal stability, and scanning electron microscopy (SEM) was applied to define morphology of films. The influence of biodegradation was also investigated in terms of changes in mechanical properties and color of samples. It was found that application of silica–lignin hybrids as fillers for PLA matrix may be interesting not only in terms of increasing thermal stability, but also controlled biodegradation. To the best knowledge of the authors, this is the first publication regarding biodegradation of PLA composites loaded with silica–lignin hybrid fillers.
Promising Tensile and Fatigue Properties of Commercially Pure Titanium Processed by Rotary Swaging and Annealing Treatment
Authors: Wang Mingsai , Wang Yanfei , Huang Aihui , Gao Lei , Li Yusheng , Huang Chongxiang
Published: November 2018

The effect of the grain refinement and texture on tensile and fatigue properties in commercially pure titanium (grade 2) processed by rotary swaging (RS) and an annealing treatment is investigated. The as-processed sample consists of band-like grains on the longitudinal section and equiaxed grains on the transversal section and revealed an obvious <10-10> fiber texture with respect to the rod axis. Through this technique, a sample with a high tensile strength of 870 MPa, a high uniform elongation of 8.5%, and a high fatigue limit of 490 MPa can be achieved, and the tensile and fatigue properties are almost the same as those of a conventional Ti-6Al-4V alloy. The enhanced mechanical properties and plastic deformation mechanism are discussed in terms of the observed ultrafine-grained microstructure and strong fiber texture.
Composite Film Based on Pulping Industry Waste and Chitosan for Food Packaging
Authors: Xu Ji-Dong , Niu Ya-Shuai , Yue Pan-Pan , Hu Ya-Jie , Bian Jing , Li Ming-Fei , Peng Feng , Sun Run-Cang
Published: November 2018

Wood auto-hydrolysates (WAH) are obtained in the pulping process by the hydrothermal extraction, which contains lots of hemicelluloses and slight lignin. WAH and chitosan (CS) were introduced into this study to construct WAH-based films by the casting method. The FT-IR results revealed the crosslinking interaction between WAH and CS due to the Millard reaction. The morphology, transmittance, thermal properties and mechanical properties of composite WAH/CS films were investigated. As the results showed, the tensile strength, light transmittances and thermal stability of the WAH-based composite films increased with the increment of WAH/CS content ratio. In addition, the results of oxygen transfer rate (OTR) and water vapor permeability (WVP) suggested that the OTR and WVP values of the films decreased due to the addition of CS. The maximum value of tensile strengths of the composite films achieved 71.2 MPa and the OTR of the films was low as 0.16 cm3·μm·m−2·24 h−1·kPa−1, these properties are better than those of other hemicelluloses composite films. These results suggested that the barrier composite films based on WAH and CS will become attractive in the food packaging application for great mechanical properties, good transmittance and low oxygen transfer rate.
In Vitro Efficacy of Antibiotics Released from Calcium Sulfate Bone Void Filler Beads
Authors: Laycock Phillip A. , Cooper John J. , Howlin Robert P. , Delury Craig , Aiken Sean , Stoodley Paul
Published: November 2018

15 different antibiotics were individually mixed with commercially available calcium sulfate bone void filler beads. The antibiotics were: amikacin, ceftriaxone, cefuroxime, ciprofloxacin, clindamycin, colistamethate sodium, daptomycin, gentamicin, imipenem/cilastatin, meropenem, nafcillin, rifampicin, teicoplanin, tobramycin and vancomycin. The efficacy of specific released antibiotics was validated by zone of inhibition (ZOI) testing using a modified Kirby–Bauer disk diffusion method against common periprosthetic joint infection pathogens. With a subset of experiments (daptomycin, rifampin, vancomycin alone and rifampin and vancomycin in combination), we investigated how release varied over 15 days using a repeated ZOI assay. We also tested the ability of these beads to kill biofilms formed by Staphylococcus epidermidis 35984, a prolific biofilm former. The results suggested that certain antibiotics could be combined and released from calcium sulfate with retained antibacterial efficacy. The daptomycin and rifampin plus vancomycin beads showed antimicrobial efficacy for the full 15 days of testing and vancomycin in combination with rifampin prevented resistant mutants. In the biofilm killing assay, all of the antibiotic combinations showed a significant reduction in biofilm bacteria after 24 h. The exposure time was an important factor in the amount of killing, and varied among the antibiotics.
Multi-Objective Optimization for Grinding of AISI D2 Steel with Al2O3 Wheel under MQL
Authors: Khan Aqib Mashood , Jamil Muhammad , Mia Mozammel , Pimenov Danil Yurievich , Gasiyarov Vadim Rashitovich , Gupta Munish Kumar , He Ning
Published: November 2018

In the present study, the machinability indices of surface grinding of AISI D2 steel under dry, flood cooling, and minimum quantity lubrication (MQL) conditions are compared. The comparison was confined within three responses, namely, the surface quality, surface temperature, and normal force. For deeper insight, the surface topography of MQL-assisted ground surface was analyzed too. Furthermore, the statistical analysis of variance (ANOVA) was employed to extract the major influencing factors on the above-mentioned responses. Apart from this, the multi-objective optimization by Grey–Taguchi method was performed to suggest the best parameter settings for system-wide optimal performance. The central composite experimental design plan was adopted to orient the inputs wherein the inclusion of MQL flow rate as an input adds addition novelty to this study. The mathematical models were formulated using Response Surface Methodology (RSM). It was found that the developed models are statistically significant, with optimum conditions of depth of cut of 15 µm, table speed of 3 m/min, cutting speed 25 m/min, and MQL flow rate 250 mL/h. It was also found that MQL outperformed the dry as well as wet condition in surface grinding due to its effective penetration ability and improved heat dissipation property.
Drug Release of Hybrid Materials Containing Fe(II)Citrate Synthesized by Sol-Gel Technique
Authors: Catauro Michelina , Tranquillo Elisabetta , Barrino Federico , Blanco Ignazio , Dal Poggetto Francesco , Naviglio Daniele
Published: November 2018

The use of oral iron integration is commonly recommended for the treatment of iron deficiency, nevertheless the diagnosis and treatment of this disease could clearly be improved. The aim of this work was the synthesis of therapeutic systems, iron (II) based, by sol-gel method. In an SiO2 matrix, we embedded different weight percentages of polyethylene glycol (PEG6, 12, 24 wt%) and ferrous citrate (Fe(II)C5, 10, 15 wt%) for drug delivery applications. Fourier Transform Infrared (FTIR) spectroscopy was used to study the interactions among different components in the hybrid materials. Release kinetics in a simulated body fluid (SBF) were investigated and the amount of Fe2+ released was detected by Ultraviolet–Visible spectroscopy (UV-VIS) after reaction with ortho-phenantroline. Furthermore, the biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated by the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using FTIR spectroscopy. Finally, also, the potential antibacterial properties of the different materials against two different bacteria, E. coli and P. aeruginosa, were investigated.
A Comparison of Electrochemical Performance of Carbon Aerogels with Adsorption Metal Ions for Super Capacitors
Authors: Dong Xiaoxi , Xu Yuelong , Wang Shasha , Zhao Junping , Ren Bin , Zhang Lihui , Liu Zhenfa
Published: November 2018

Environmental problems caused by metal ions have caused widespread concern in recent years. In this work, carbon aerogels (CAs) adsorbing different metal ions were prepared. The adsorption performance and kinetics of metal ions (Cu(II), Cr(VI), and Fe(III)) on carbon aerogels were systematically investigated. The results indicated that the maximum adsorption capacity of Cu(II) was 424 mg·g−1 in 600 mg·L−1 copper solution. Adsorption performances of Cu(II), Cr(VI), and Fe(III) on CAs well fitted with a pseudo-second-order kinetic model. The structures and morphologies of metal-containing samples were characterized by scanning electron micrographs (SEM), Energy Dispersive Spectrometer (EDS), transmission electron microscope (TEM), and X-ray diffraction (XRD). The results demonstrated that the texture and electrochemical performance of CAs adsorbing metal ions exhibited a clear change. The specific surface area of CAs for adsorbing copper ions was 450 m2·g−1 and they showed a small average pore diameter (7.16 nm). Furthermore, CAs adsorbing metals could be used for the super capacitor. The specific capacitance of CAs adsorbing copper ions could reach 255 F·g−1 at a current density of 1.0 A·g−1. The CA-Cu electrode materials exhibited excellent reversibility with a cycling efficiency of 97% after 5000 cycles.
Experimental Investigation on the Creep Property of Carbon Fiber Reinforced Polymer Tendons under High Stress Levels
Authors: Yang Dong , Zhang Jiwen , Song Shoutan , Zhou Fei , Wang Chao
Published: November 2018

Carbon fiber reinforced polymer (CFRP) tendons are generally used as prestressing members to take full advantage of their high strength. Their creep property is one of the key factors influencing the reliability and safety of the structures, especially under sustained high stress. In this study, using a new wedge-type anchorage system, experimental research was carried out on the creep behavior of CFRP tendons under high stress levels from 0.69 to 0.85 fu. All the tests lasted for a duration of 1000 h. It was found that the creep coefficient tends to increase with the stress level. Compared to their static properties, the residual strength of CFRP tendons after creep tests is 4.54% lower while the after-creep elastic modulus is 6.99% higher. Through data analysis, a semi-logarithm linear relationship between the creep coefficient and time was established, and the creep coefficients at 1 million hours were extrapolated.
Hydrothermally Synthesized Mg-Based Spinel Nanoferrites: Phase Formation and Study on Magnetic Features and Microwave Characteristics
Authors: Tsay Chien-Yie , Chiu Yi-Chun , Lei Chien-Ming
Published: November 2018

Three kinds of magnesium-based spinel nanoferrites with the chemical formulas of MgFe2O4 (Mg ferrite), Mg0.9Mn0.1Fe2O4 (Mg-Mn ferrite), and Mg0.9Mn0.1In0.1Fe1.9O4 (Mg-Mn-In ferrite) were synthesized by hydrothermal route. We report the composition-dependent magnetic parameters and microwave properties of Mg-based ferrite nanoparticles. XRD results revealed that the Mg-based ferrite nanoparticles exhibited a cubic spinel structure and had an average nanocrystallite size in the range of 5.8–2.6 nm. Raman spectroscopy analysis confirmed the formation of cubic-spinel phase Mg-based nanoferrites. The room-temperature magnetization measurements indicated that the Mg ferrite nanoparticles had superparamagnetic behavior; whereas the Mg-Mn and Mg-Mn-In ferrite nanoparticles exhibited a paramagnetic nature. The microwave properties of obtained ferrite nanoparticles were studied by alternating current (AC) magnetic susceptibility measurement and electron paramagnetic resonance (EPR) spectroscopy. It was found that the un-substituted Mg ferrite sample exhibited microwave characteristics better than those of the Mn substituted and Mn-In co-substituted Mg ferrite samples.
Biochemical and Anti-Triple Negative Metastatic Breast Tumor Cell Properties of Psammaplins
Authors: Zhou Yu-Dong , Li Jun , Du Lin , Mahdi Fakhri , Le Thuy P. , Chen Wei-Lun , Swanson Steven M. , Watabe Kounosuke , Nagle Dale G.
Published: November 2018

Breast tumors reprogram their cellular metabolism, nutrient uptake, and utilization-associated biochemical processes. These processes become further transformed as genetically predisposed metastatic breast tumor cells colonize specific organs. Breast tumor cells often metastasize to the brain, bone, lung and liver. Massagué and colleagues isolated organotropic subclones and established organ-specific gene signatures associated with lung-, bone-, and brain-specific metastatic triple-negative breast cancer (TNBC) MDA-MB-231 cells. Using these genetically characterized metastatic subclones specific to lung (LM4175), bone (BoM1833), and brain (BrM-2a), we evaluated marine natural products for the ability to differentially suppress metastatic breast cancer cells in a target organ-dependent manner. Psammaplin-based histone deacetylase (HDAC) inhibitors were found to differentially inhibit HDAC activity, induce activation of hypoxia-inducible factor-1 (HIF-1), and disrupt organotropic metastatic TNBC subclone growth. Further, psammaplins distinctly suppressed the outgrowth of BoM1833 tumor spheroids in 3D-culture systems. Similar results were observed with the prototypical HDAC inhibitor trichostatin A (TSA). These organotropic tumor cell-based studies suggest the potential application of HDAC inhibitors that may yield new directions for anti-metastatic breast tumor research and drug discovery.