bluuebunny/crossref_metadata_2025 huggingface dataset:
The Isolation, Structural Characterization and Anti-Inflammatory Potentials of Neutral Polysaccharides from the Roots of Isatis indigotica Fort.
Authors: Shen Yu , Wu Shihao , Song Mingming , Zhang Huiming , Zhao Hong , Wu Lili , Zhao Hongbo , Qiu Hongbin , Zhang Yu
Published: June 2024

Polysaccharides have been assessed as a potential natural active component in Chinese herbal medicine with anti-inflammatory properties. However, the complex and indefinite structures of polysaccharides limit their applications. This study explains the structures and anti-inflammatory potentials of three neutral polysaccharides, RIP-A1 (Mw 1.8 × 104 Da), RIP-B1 (Mw 7.4 × 104 Da) and RIP-B2 (Mw 9.3 × 104 Da), which were isolated from the roots of Isatis indigotica Fort. with sequenced ultrafiltration membrane columns, DEAE-52 and Sephadex G-100. The planar structures and microstructures of RIP-A1, RIP-B1 and RIP-B2 were further determined by HPGPC, GC–MS, methylation analysis, FT-IR, SEM and AFM, in which the structure of RIP-A1 was elucidated in detail using 1D/2D NMR. The Raw 264.7 cells were used for the anti-inflammatory activity in vitro. The results showed that RIP-A1, RIP-B1 and RIP-B2 are all neutral polysaccharides, with RIP-A1 having the smallest Mw and the simplest monosaccharide composition of the three. RIP-A1 is mainly composed of Ara and Gal, except for a small quantity of Rha. Its main structure is covered with glycosidic linkages of T-α-Araf, 1,2-α-Rhap, 1,5-α-Araf, T-β-Galp, 1,2,4-α-Rhap, 1,3,5-α-Araf and 1,6-β-Galp with 0.33:0.12:1.02:0.09:0.45:11.41:10.23. RIP-A1 significantly inhibited pro-inflammatory cytokines (NO, TNF-α, IL-6 and IL-1β) and increased anti-inflammatory cytokines (IL-4) in LPS-stimulated RAW 264.7 cells. Moreover, RIP-A1 could significantly inhibit the mRNA expression of TNF-α, IL-6 and L-1β. It could also activate IKK, p65 and IκBα (the components of the NF-κB signaling pathway). In conclusion, the above results show the structural characterization and anti-inflammatory potentials of RIP-A1 as an effective natural anti-inflammatory drug.
Emerging Trends in Nanotechnology for Endometriosis: Diagnosis to Therapy
Authors: Talukdar Souvanik , Singh Santosh K. , Mishra Manoj K. , Singh Rajesh
Published: June 2024

Endometriosis, an incurable gynecological disease that causes abnormal growth of uterine-like tissue outside the uterine cavity, leads to pelvic pain and infertility in millions of individuals. Endometriosis can be treated with medicine and surgery, but recurrence and comorbidities impair quality of life. In recent years, nanoparticle (NP)-based therapy has drawn global attention, notably in medicine. Studies have shown that NPs could revolutionize conventional therapeutics and imaging. Researchers aim to enhance the prognosis of endometriosis patients with less invasive and more effective NP-based treatments. This study evaluates this potential paradigm shift in endometriosis management, exploring NP-based systems for improved treatments and diagnostics. Insights into nanotechnology applications, including gene therapy, photothermal therapy, immunotherapy, and magnetic hyperthermia, offering a theoretical reference for the clinical use of nanotechnology in endometriosis treatment, are discussed in this review.
Evaluation of the Consumption of Junk Food Products and Lifestyle among Teenagers and Young Population from Romania
Authors: Mititelu Magdalena , Stanciu Gabriela , Licu Monica , Neacșu Sorinel Marius , Călin Mariana Floricica , Roșca Adrian Cosmin , Stanciu Tiberius Iustinian , Busnatu Ștefan Sebastian , Olteanu Gabriel , Boroghină Steluța Constanța , Nicolescu Teodor Octavian , Suciu Felicia , Lupu Carmen Elena
Published: June 2024

Background: The long-term consumption of junk food products can lead to nutritional and metabolic imbalances, especially when it is associated with a lack of physical activity and the consumption of alcohol or other high-calorie products. Methods: The evaluation of junk food consumption among teenagers and young people in Romania was carried out with the help of a cross-sectional study based on a questionnaire. Results: A total number of 1017 respondents participated in this study, comprising 470 males and 547 females aged between 16 and 25 years. Although the majority of young people fell into the normal-weight category (607 of them, p < 0.0001), some aspects can be noted that in the long term can produce a series of nutritional imbalances: an increased tendency toward sedentarism, with 553 (p = 0.613) of the respondents declaring that they performed sports rarely or not at all, and a tendency toward relatively high consumption of foods high in calories (fast food products and especially fried potatoes, hamburgers, shawarma, pastries, and snacks, along with sweetened drinks and even alcoholic beverages). The respondents participating in this study even indicated a perceived addiction to the consumption of certain products: coffee (50.48%), fried potatoes (38.9%), hamburgers (37.05%), shawarma (31.65%), and snacks (30.08%). Many of these products are rich in calories, saturated fat, and even trans fat. Conclusions: This study highlights a series of aspects that can have long-term negative effects related to the excess weight associated with other imbalances: consumption preferences among young people for hypercaloric fast food products, sweetened drinks associated with reduced physical activity, and even the development of some forms of food addictions for a series of hypercaloric foods.
An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Lopresti Adrian L. , Smith Stephen J. , Riggs Melanie L. , Major Rebecca A. , Gibb Tanner G. , Wood Steven M. , Hester Shelly N. , Knaggs Helen E.
Published: June 2024

Background: Dietary quality and the consumption of antioxidant-rich foods have been shown to protect against memory decline. Therefore, this double-blind, randomized, placebo-controlled study aimed to investigate the effects of a nutritional supplement on changes in cognitive performance. Methods: In adults aged 40 to 70 years with subjective memory complaints, participants were randomly allocated to take a supplement containing vitamin E, astaxanthin, and grape juice extract daily for 12 weeks or a matching placebo. The primary outcomes comprised changes in cognitive tasks assessing episodic memory, working memory, and verbal memory. Secondary and exploratory measures included changes in the speed of information processing, attention, and self-report measures of memory, stress, and eye and skin health. Moreover, changes in plasma concentrations of brain-derived neurotrophic factor, malondialdehyde, tumor-necrosis factor-α, and interleukin-6 were measured, along with changes in skin carotenoid concentrations. Results: Compared to the placebo, nutritional supplementation was associated with larger improvements in one primary outcome measure comprising episodic memory (p = 0.037), but not for working memory (p = 0.418) or verbal learning (p = 0.841). Findings from secondary and exploratory outcomes demonstrated that the nutraceutical intake was associated with larger improvements in the Everyday Memory Questionnaire (p = 0.022), increased plasma brain-derived neurotrophic factor (p = 0.030), decreased plasma malondialdehyde (p = 0.040), and increased skin carotenoid concentrations (p = 0.006). However, there were no group differences in changes in the remaining outcome measures. Conclusions: Twelve weeks of supplementation with a nutritional supplement was associated with improvements in episodic memory and several biological markers associated with cognitive health. Future research will be essential to extend and validate the current findings.
Comment on Jakše et al. Vegan Diets for Children: A Narrative Review of Position Papers Published by Relevant Associations. Nutrients 2023, 15, 4715
Authors: Benedik Evgen , Homan Matjaž , Pokorn Marko , Rotovnik Kozjek Nada , Vogrin Bernarda , Dolinšek Jernej , Homšak Matjaž , Juričič Mojca , Najdenov Peter , Baš Denis , Širca Čampa Andreja , Bratina Nataša , Battelino Tadej
Published: June 2024

We have read the recent narrative review article by Jakše et al [...]
Reply to Benedik et al. Comment on “Jakše et al. Vegan Diets for Children: A Narrative Review of Position Papers Published by Relevant Associations. Nutrients 2023, 15, 4715”
Authors: Jakše Boštjan , Fras Zlatko , Fidler Mis Nataša
Published: June 2024

Benedik et al [...]
Hypogammaglobulinemia Class G Is Present in Compensated and Decompensated Patients with Propionate Defects, Independent of Their Nutritional Status
Authors: López-Mejía Lizbeth Alejandra , Vela-Amieva Marcela , Guillén-López Sara , Mancera-Hernández Daniela , Ibarra-González Isabel , Medina-Torres Edgar Alejandro , Espinosa-Padilla Sara Elva , Fernández-Lainez Cynthia
Published: June 2024

Propionate defects (PDs) mainly include methylmalonic (MMA) and propionic acidemia (PA) defects. Lifelong PD patients progress from the compensated to the decompensated stages, the latter of which are characterized by life-threatening acidemia and hyperammonemia crises. PD patients can suffer immunocompromise, especially during the decompensation stage. There is a significant gap in the research regarding the humoral immune response in PD patients. Here, we analyzed serum immunoglobulin concentrations and hemograms across compensated and decompensated stages in PD patients. Nutritional status and crisis triggers of decompensation were also explored. Twenty patients were studied, and 25 decompensation events (DE) and 8 compensation events (CE) were recorded. Compared with those in the CE group, the IgG levels in the DE group (513.4 ± 244.5 mg/dL) were significantly lower than those in the CE group (860.8 ± 456.5 mg/dL) (p < 0.0087). The mean hemoglobin concentration was significantly lower in the DE group (11.8 g/dL) than in the CE group (13.4 g/dL) (p < 0.05). The most frequent (48%) possible decompensation trigger factor was infection. Most of the events were registered in eutrophic patients (87.9%), despite which 65.2% and 50% of patients who experienced decompensated and compensated events, respectively, presented with hypogammaglobulinemia G. These findings provide evidence of the immunodeficiency of PD patients, independent of their nutritional status. We suggest that PD patients be managed as immunocompromised independently of their nutritional status or metabolic state (compensated or decompensated).
Comparing Occurrence of Bovine Respiratory Pathogens Detected by High-Throughput Real-Time PCR in Nasal Swabs and Non-Endoscopic Bronchoalveolar Lavage Samples from Dairy and Veal Calves
Authors: Otten Nina Dam , Goecke Nicole Bakkegård , Michelsen Anne Marie , Nielsen Liza Rosenbaum , Capion Nynne , Martin Henrik Læssøe , Nielsen Bodil Højlund , Larsen Lars Erik , Petersen Mette Bisgaard
Published: June 2024

This study aimed to enhance our understanding of the agreement between two sampling methods for the detection of bovine respiratory disease (BRD) pathogens in calves using high-throughput real-time qPCR (ht-RT-qPCR). In total, 233 paired nasal swab (NS) and non-endoscopic bronchoalveolar lavage (nBAL) samples were collected from 152 calves from 12 Danish cattle herds. In 202 of the observations, the calves were examined using a standardized clinical protocol. Samples were tested for three viruses (bovine respiratory syncytial virus, bovine corona virus, and influenza D virus) and six bacteria (Histophilus somni, Mannheimia haemolytica, Mycoplasma bovis, Mycoplasma species, Pasteurella multocida, and Truepurella pyogenes). The results showed age-related differences in disease and pathogen occurrence, with the highest detection rates in calves aged 35 days or older. Poor to moderate agreement was found between the NS and nBAL results. The presence of Mannheimia haemolytica in both NS and nBAL in younger calves and in nBAL in older calves was associated with clinical BRD. There was a potential link between BRD and influenza D virus in older calves, although it was only found in one herd in a small sample size. Overall, NS was a relatively poor predictor of pathogens in the lower respiratory tract. The present study confirms the complexity of pathogen detection in BRD, with marked influences of age and the sampling method on pathogen detection and disease associations.
A Qualitative Exploration of Young Canadians’ Experiences of Undesired Dog Behaviours
Authors: Roma Renata , Tardif-Williams Christine , Moore Shannon , Pendry Patricia
Published: June 2024

There is a need for research that explores the challenges associated with dog ownership. In particular, increasing our understanding of how young people manage their dog’s undesired behaviours can inform a more nuanced perspective of dog ownership as well as highlight the impact of such interactions on both dogs and young people. This qualitative study addresses this gap in the human–animal interactions literature through a secondary analysis of a data set of transcribed semi-structured interviews with seven participants aged between 17–26 years. The data were collected during a larger investigation that focused on young people’s relationships with their dogs during the COVID-19 pandemic. Using thematic analyses, we examined interviews that probed participants’ experiences and responses when their dogs misbehaved. The findings identified and explored three emerging themes including Attachment Patterns, which was supported by the codes of connection and kinship. The second theme was Synchrony and/or Lack of Synchrony, which was supported by the codes of reaction and communication. The third theme was Response to Challenging Situations, supported by the codes of emotional reactions and coping styles. Findings suggest that participants handled their dog’s undesired behaviours in unique ways and that such situations may negatively impact their emotions. Undesired dog behaviours were not related to participants’ perceptions of poor attachment patterns towards their dogs. These findings can inform efforts to foster positive interactions between young people and their dogs and reduce dog surrenders.
Metformin Therapy for Acne Vulgaris: A Meta-Analysis
Authors: Szefler Lidia , Szybiak-Skora Weronika , Sadowska-Przytocka Anna , Zaba Ryszard , Wieckowska Barbara , Lacka Katarzyna
Published: June 2024

Acne vulgaris is a common disease, which occurs in adolescents as well as adults and has a significant influence on the patient’s quality of life (QoL) in every aspect. Due to resistance to standard therapies, it has become necessary to prospect for new treatment strategies. It is important to highlight that the diagnosis and treatment of the underlying cause of acne such as metabolic and hormonal disorders may significantly improve the effectiveness of acne treatment. The correlation between Insulin Resistance (IR) and acne has been proven. Both disorders share many common occurrence factors and activation pathways. Metformin, an antihyperglycemic agent, seems to be a possible therapy option, not only because of its insulin sensitizing ability but also via plenty of additional effects of this medicine. While the efficiency of metformin therapy in patients with acne and Polycystic Ovary Syndrome (PCOS) is well explored, it is still necessary to evaluate it in patients without any endocrinopathies. This meta-analysis aimed to estimate the effectiveness of oral metformin as a monotherapy in acne patients without PCOS or other endocrinopathies. Study selection was performed with included criteria such as no PCOS and other endocrinopathies diagnosed, oral administration of metformin, and metformin in monotherapy. Selected studies contained comparisons in the Global Acne Grading System (GAGS) before and after metformin therapy. Statistical analysis detected significant improvement in skin condition after treatment with metformin.
Exploring the Underlying Mechanisms of Qingxing Granules Treating H1N1 Influenza Based on Network Pharmacology and Experimental Validation
Authors: Du Hujun , Zhang Lianying , Sun Haoxiang , Zheng Shaoqin , Zhang Hongying , Yuan Shijia , Zhou Jiuyao , Fang Zihao , Song Jianping , Mei Manxue , Deng Changsheng
Published: June 2024

Background: H1N1 is one of the major subtypes of influenza A virus (IAV) that causes seasonal influenza, posing a serious threat to human health. A traditional Chinese medicine combination called Qingxing granules (QX) is utilized clinically to treat epidemic influenza. However, its chemical components are complex, and the potential pharmacological mechanisms are still unknown. Methods: QX’s effective components were gathered from the TCMSP database based on two criteria: drug-likeness (DL ≥ 0.18) and oral bioavailability (OB ≥ 30%). SwissADME was used to predict potential targets of effective components, and Cytoscape was used to create a “Herb-Component-Target” network for QX. In addition, targets associated with H1N1 were gathered from the databases GeneCards, OMIM, and GEO. Targets associated with autophagy were retrieved from the KEGG, HAMdb, and HADb databases. Intersection targets for QX, H1N1 influenza, and autophagy were identified using Venn diagrams. Afterward, key targets were screened using Cytoscape’s protein–protein interaction networks built using the database STRING. Biological functions and signaling pathways of overlapping targets were observed through GO analysis and KEGG enrichment analysis. The main chemical components of QX were determined by high-performance liquid chromatography (HPLC), followed by molecular docking. Finally, the mechanism of QX in treating H1N1 was validated through animal experiments. Results: A total of 786 potential targets and 91 effective components of QX were identified. There were 5420 targets related to H1N1 and 821 autophagy-related targets. The intersection of all targets of QX, H1N1, and autophagy yielded 75 intersecting targets. Ultimately, 10 core targets were selected: BCL2, CASP3, NFKB1, MTOR, JUN, TNF, HSP90AA1, EGFR, HIF1A, and MAPK3. Identification of the main chemical components of QX by HPLC resulted in the separation of seven marker ingredients within 195 min, which are amygdalin, puerarin, baicalin, phillyrin, wogonoside, baicalein, and wogonin. Molecular docking results showed that BCL2, CASP3, NFKB1, and MTOR could bind well with the compounds. In animal studies, QX reduced the degenerative alterations in the lung tissue of H1N1-infected mice by upregulating the expression of p-mTOR/mTOR and p62 and downregulating the expression of LC3, which inhibited autophagy. Conclusions: According to this study’s network pharmacology analysis and experimental confirmation, QX may be able to treat H1N1 infection by regulating autophagy, lowering the expression of LC3, and increasing the expression of p62 and p-mTOR/mTOR.
Amicis Omnia Sunt Communia: NF-κB Inhibition as an Alternative to Overcome Osteosarcoma Heterogeneity
Authors: Medeiros Mariana , Guenka Sophia , Bastos David , Oliveira Karla Laissa , Brassesco María Sol
Published: June 2024

Tumor heterogeneity poses a significant challenge in osteosarcoma (OS) treatment. In this regard, the “omics” era has constantly expanded our understanding of biomarkers and altered signaling pathways (i.e., PI3K/AKT/mTOR, WNT/β-catenin, NOTCH, SHH/GLI, among others) involved in OS pathophysiology. Despite different players and complexities, many commonalities have been described, among which the nuclear factor kappa B (NF-κB) stands out. Its altered activation is pervasive in cancer, with pleiotropic action on many disease-relevant traits. Thus, in the scope of this article, we highlight the evidence of NF-κB dysregulation in OS and its integration with other cancer-related pathways while we summarize the repertoire of compounds that have been described to interfere with its action. In silico strategies were used to demonstrate that NF-κB is closely coordinated with other commonly dysregulated signaling pathways not only by functionally interacting with several of their members but also by actively participating in the regulation of their transcription. While existing inhibitors lack selectivity or act indirectly, the therapeutic potential of targeting NF-κB is indisputable, first for its multifunctionality on most cancer hallmarks, and secondly, because, as a common downstream effector of the many dysregulated pathways influencing OS aggressiveness, it turns complex regulatory networks into a simpler picture underneath molecular heterogeneity.
Trametinib, a MEK1/2 Inhibitor, Protects Mice from Cisplatin- and Noise-Induced Hearing Loss
Authors: Lutze Richard D. , Ingersoll Matthew A. , Kelmann Regina G. , Teitz Tal
Published: June 2024

Hearing loss is one of the most common types of disability; however, there is only one FDA-approved drug to prevent any type of hearing loss. Treatment with the highly effective chemotherapy agent, cisplatin, and exposure to high-decibel noises are two of the most common causes of hearing loss. The mitogen-activated protein kinase (MAPK) pathway, a phosphorylation cascade consisting of RAF, MEK1/2, and ERK1/2, has been implicated in both types of hearing loss. Pharmacologically inhibiting BRAF or ERK1/2 is protective against noise- and cisplatin-induced hearing loss in multiple mouse models. Trametinib, a MEK1/2 inhibitor, protects from cisplatin-induced outer hair cell death in mouse cochlear explants; however, to the best of our knowledge, inhibiting MEK1/2 has not yet been shown to be protective against hearing loss in vivo. In this study, we demonstrate that trametinib protects against cisplatin-induced hearing loss in a translationally relevant mouse model and does not interfere with cisplatin’s tumor-killing efficacy in cancer cell lines. Higher doses of trametinib were toxic to mice when combined with cisplatin, but lower doses of the drug were protective against hearing loss without any known toxicity. Trametinib also protected mice from noise-induced hearing loss and synaptic damage. This study shows that MEK1/2 inhibition protects against both insults of hearing loss, as well as that targeting all three kinases in the MAPK pathway protects mice from cisplatin- and noise-induced hearing loss.
The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment
Authors: Seoane-Viaño Iria , Seoane-Gigirey Mariola , Bendicho-Lavilla Carlos , Gigirey Luz M. , Otero-Espinar Francisco J. , Seoane-Trigo Santiago
Published: June 2024

Despite the high success rates of dental implants, peri-implantitis is currently the most common complication in dental implantology. Peri-implantitis has an inflammatory nature, it is associated with the accumulation of plaque in the peri-implant tissues, and its evolution can be progressive depending on various factors, comorbidities, and poor oral health. Prophylaxis and different treatment methods have been widely discussed in recent decades, and surgical and non-surgical techniques present both advantages and disadvantages. In this work, a literature review of different studies on the application of adjuvant treatments, such as local and systemic antibiotics and antiseptic treatments, was conducted. Positive outcomes have been found in the short (up to one year after treatment) and long term (up to ten years after treatment) with combined therapies. However, there is still a need to explore new therapies based on the use of advanced drug delivery systems for the effective treatment of peri-implantitis in the long term and without relapses. Hence, micro- and nanoparticles, implants, and injectable hydrogels, among others, should be considered in future peri-implantitis treatment with the aim of enhancing overall therapy outcomes.
Pharmacists’ Behavioral Changes after Attending a Multi-Prefectural Palliative Care Education Program
Authors: Yamada Masahiro , Uchida Mayako , Hada Masao , Wakabayashi Haruka , Inma Daigo , Ariyoshi Shunji , Kamimura Hidetoshi , Haraguchi Tohru
Published: June 2024

Central to the pharmacist’s role in palliative care is symptom management through direct participation in patient care and the provision of optimal pharmacotherapy to support patient outcomes. Consequently, palliative care requires extensive knowledge and action for patients with cancer. Therefore, this study aimed to evaluate how pharmacists’ behavior changed after attending a palliative care educational program. We conducted a web-based questionnaire survey examining the behavior of pharmacists regarding palliative care before participating in the program, two months after participating in the program, and eight months after participating in the program to determine their behavior and changes over time. For all questions, scores were higher at two and eight months after attending the program than before attending the program (p < 0.05). In addition, no significant difference was observed between two and eight months after attending the program for any question (p = 0.504–1.000). The knowledge gained from the educational program was used to repeatedly intervene with patients with cancer in order to address the various symptoms they experienced and maintain their behavior. The proven effectiveness of this program serves as a stepping stone for nationwide rollout across Japan’s 47 prefectures.
Exposure of Pharmacists and Pharmacy Technicians to Violence in Community Pharmacies in Southeast Europe: Frequency and Ethical Considerations
Authors: Popčević Monika , Javorina Tanja , Košiček Miljenko , Meštrović Arijana
Published: June 2024

Pharmacists and pharmacy technicians working in community pharmacies are exposed to the risk of violence in their workplaces. Studies have shown that workplace violence is affecting their job satisfaction, productivity, and mental health. This study aims to identify the frequency of different types of violence, as well as the common perpetrators that community pharmacy staff in SEE (Southeast Europe) are dealing with. A cross-sectional study was conducted using an online questionnaire created for this purpose. Selected community pharmacies in Croatia, Serbia, Bosnia and Herzegovina, and Montenegro participated in this study. In total, 732 responses were collected from 24 pharmacy chains or independent pharmacies including all community pharmacy staff. More than 80% of pharmacists and pharmacy technicians reported having been exposed to verbal violence at the workplace, while more than 20% of them reported physical and sexual violence in the preceding 12 months. There were no statistically significant differences between pharmacists and pharmacy technicians, gender, age groups, or countries in relation to exposure to physical, verbal, and sexual violence. The most common perpetrators were identified as patients/clients. More than 90% of pharmacy staff reported they did not receive any kind of support from their employer nor any other help after experiencing a robbery. There is a need for a structured approach to addressing violence in pharmacies including organized support for pharmacy staff. Achieving quality patient care, despite dealing with violent individuals or situations daily, is one of the greatest ethical challenges for healthcare providers in community pharmacies to be empowered.
Bessarion on the Value of Oral Teaching and the Rule of Secrecy
Authors: Steiris Georgios
Published: June 2024

Cardinal Bessarion (1408–1472), in the second chapter of the first book of his influential work In calumniatorem Platonis, attempted to reply to Georgios Trapezuntios’ (1396–1474) criticism against Plato in the Comparatio Philosophorum Platonis et Aristotelis. Bessarion investigates why the Athenian philosopher maintained, in several dialogues, that the sacred truths should not be communicated to the general public and argued in favor of the value of oral transmission of knowledge, largely based on his theory about the cognitive processes. Recently, Fr. Bessarion Kouotsis has argued that Cardinal Bessarion’s reasoning draws primarily on the “Disciplina Arcani”, i.e., the rule of secrecy, which was an established practice of the Early Christian Church, aimed at protecting and preserving the core elements of the religion from outsiders. While I find Kouotsis’ approach interesting and thought-provoking—for instance, the idea that Bessarion’s argumentation was likely influenced by Eastern Christian views on the rule of secrecy—I intend, first of all, to discuss why Bessarion did not explicitly mention it. Moreover, I would like to argue that Bessarion’s good knowledge of the long Platonic tradition and Eastern mysticism, encompassing both pagan and Christian elements, should also be considered a significant source. Furthermore, I would like to question Kouotsis’ implicit argument that Bessarion’s views were dominated by his training in Orthodox theology and discuss the possibility that Pletho’s (1355–1454) teaching was the obvious influence for Bessarion’s defense of secrecy. After all, we should bear in mind that Anastos has already pointed out Pletho’s reverence for the rule of secrecy. Finally, I would like to support that Bessarion, in the specific text, focused predominantly on the epistemological and cognitive aspects of oral teaching, resorting to the rule of secrecy only to enhance his views.
Single-Source VLCP System Based on Solar Cell Array Receiver and Right-Angled Tetrahedron Trilateration VLP (RATT-VLP) Algorithm
Authors: Xie Dawei , Liu Zhongxu , Yu Changyuan
Published: June 2024

A significant deployment limitation for visible light communication and positioning (VLCP) systems in energy- and light-source-restricted scenarios is the reliance of photodetectors (PDs) on external power supplies, compromising sustainability and complicating receiver charging. Solar cells (SCs), capable of harvesting and converting environmental light into electrical energy, offer a promising alternative. Consequently, we first propose an indoor VLCP system that utilizes an SC array as the receiver, alongside a right-angled tetrahedron trilateration visible light positioning (RATT-VLP) algorithm based on a single light source and multiple receivers. The proposed system uses an SC array in place of PDs, utilizing binary phase shift keying (BPSK) signals for simultaneous communication and positioning. In experiments, we verified the system’s error-free communication rate of 1.21 kbps and average positioning error of 3.40 cm in a 30 cm × 30 cm area, indicating that the system can simultaneously satisfy low-speed communication and accurate positioning applications. This provides a viable foundation for further research on SC-based VLCP systems, facilitating potential applications in environments like underwater wireless communication, positioning, and storage tank inspection.
Influence of Pump Light on LP01 and LP11 Modes in Few-Mode Fiber Brillouin Optical Time Domain Reflectometry
Authors: Hao Yunqi , Han Yiliang , Liao Weitong , Miao Miao , Yang Kun
Published: June 2024

The quality of pump pulse in few-mode-fiber Brillouin optical time domain reflectometry (FMF-BOTDR) is vital for the spontaneous Brillouin scattering of modes LP01 and LP11 because it is the comprehensive effect of the main laser linewidth and pulse width, which is firstly discussed as we know. Numerical and experimental analysis are made for the amplitude and linewidth distribution, corresponding to the signal–noise ratio (SNR) and frequency resolution in BOTDR, respectively. Simulation shows the linewidths and peak values of Brillouin scattering have the same tendency for the LP01 mode and LP11 mode when the laser linewidth is less than 1 MHz but decreases slowly until they are the same when the laser linewidth is wider than 1 MHz. With the pulse width widening, the Brillouin linewidths for LP01 and LP11 modes both decrease sharply, almost to the natural linewidth of fiber 41 MHz and 35 MHz. Experimental results show that the amplitude distribution for the LP01 mode is always larger than for the LP11 mode if the main laser has the same linewidth and the frequency fluctuation is at least 2 MHz with the fiber laser and LP11 mode. The above results could provide improved sensing resolution for FMF-BOTDR sensing system.
Can Environmental Stressors Determine the Condition of Ecological Plant Groups?
Authors: Koim-Puchowska Beata , Kamiński Piotr , Puchowski Piotr , Ossowska Anna , Wieloch Monika , Labudda Mateusz , Tkaczenko Halina , Barczak Tadeusz , Woźniak Alina , Kurhaluk Natalia
Published: June 2024

There is still a need to investigate the relationships between glycophytes and halophytes and the many biotic and abiotic factors in their natural environments. Therefore, we study the effects of the type of environment on the ecophysiological responses and condition of the glycophyte Elder Sambucus nigra L., the macrophyte Common Reed Phragmites australis (Cav.) Trin. ex Steud., the facultative halophyte Weeping Alkaligrass Puccinellia distans (Jacq.) Parl, and the obligate halophyte Common Glasswort Salicornia europaea L. in a saline-disturbed anthropogenic region of central Poland. We analyzed the effects of salinity, acidity, and soil organic matter on shoot length, lipoperoxidation, and proline in roots and green parts, and evaluated plant responses to environmental disturbance, which allowed for the comparison of adaptation strategies. The studies were carried out in (1) “sodium production” (near sodium factories), (2) “anthropogenic environments” (waste dumps, agroecosystems, calcium deposits, post-production tanks), (3) “wetland environments” (near river channels and riparian areas), and (4) “control” (natural, unpolluted environments). Green parts of plants are better suited to indicate environmental stress than roots. Their higher structural MDA membrane damage is related to the transport of toxic ions to the shoots by a rapid transpiration stream in the xylem. We found high salinity to be the main factor inducing growth and found it to be correlated with the high pH effect on proline increase in glycophytes (Elder, Reed) and Weeping Alkaligrass, in contrast to Common Glasswort. We suggest that proline accumulation allows osmotic adjustment in the green parts of reeds and alkaligrasses, but may have another function (in Elder). Common Glasswort accumulates large amounts of Na+, which is energetically more effective than proline accumulation for osmotic adjustment. Organic matter affects plant growth and proline levels, but soil salinity and pH alter nutrient availability. Plant distribution along the salinity gradient indicates that Elder is the most salt-sensitive species compared to Reed, Alkaligrass, and Glasswort. Salinity and the lack of control of thick reeds, which compete with other plant groups, affect the distribution of halophytes in saline environments.
Understanding Arctic–Alpine Plants from Ecological and Evolutionary Perspectives
Authors: Kozlowski Gregor
Published: June 2024

Conditions in arctic and alpine ecosystems impose great challenges on the plants and other organisms that live there [...]
Forecast the Habitat Sustainability of Schoenus ferrugineus L. (Cyperaceae) in the Southern Urals under Climate Change
Authors: Fedorov Nikolay , Muldashev Albert , Mikhaylenko Oksana , Zhigunova Svetlana , Baisheva Elvira , Shirokikh Pavel , Bikbaev Ilnur , Martynenko Vasiliy
Published: June 2024

An analysis of the current potential range of the Pleistocene relict plant species Schoenus ferrugineus and modeling of changes in its future range under moderate (RCP4.5) and strong (RCP8.5) climate change in the middle and second half of the 21st century were carried out. The MaxEnt program was used for modeling. Climate variables from CHELSA Bioclim, the global digital soil mapping system SoilGrids, and a digital elevation model were used as predictors. Modeling has shown that climate change will lead to a significant reduction in the suitability of S. ferrugineus habitat conditions by the mid-21st century. The predicted changes in the distribution of habitats of S. ferrugineus, a diagnostic species of calcareous mires and an indicator of their ecological state, indicate a possible strong transformation of wetland complexes in the Southern Urals region even under moderate climate change. A reduction in the distribution of S. ferrugineus at the eastern limit of its range will also be facilitated by more frequent extreme droughts. To maintain the distribution of S. ferrugineus on the eastern border of its range, a number of measures are proposed to mitigate the negative consequences of climate change, contributing to the preservation of the hydrological regime of calcareous mires.
Ethnobotanical Survey of Culturally Important Plants and Mushrooms in North-Western Part of Croatia
Authors: Krstin Ljiljana , Katanić Zorana , Benčić Katarina , Lončar Laura , Pfeiffer Tanja Žuna
Published: June 2024

The Republic of Croatia is spread in geographical and climatic conditions that support a great diversity of habitats and associated plant taxa, many of which can be used for food or medicine. However, urbanization, loss of natural habitats, as well as changes in people’s dependence on the natural resources from the surrounding environment may lead to the loss of valuable knowledge about the use of plants and mushrooms. With the aim of studying and preserving this knowledge in the continental north-western part of Croatia, an ethnobotanical survey was undertaken at the two study areas—Valpovo and Đurđevac, which included a total of 17 settlements. A total of 103 informants, 65% female and 35% male, aged between 22 and 83 years, participated in an interview using pre-planned questionnaires. The informants reported 131 plants belonging to 55 families and 17 mushroom taxa. The largest number of plants belonged to the families of Rosaceae, Lamiaceae, Asteraceae, and Apiaceae. In both areas, the informants cultivate and also gather wild plants, but these practices are better preserved in the area of Đurđevac where 109 taxa from 47 families were recorded. In addition to cultivated and gathered plants, informants from the Valpovo area also reported the use of purchased plants. Plants and mushrooms are mostly used as food (21 plant taxa and 17 mushrooms), but plants also serve as medicine (68 taxa), as both food and medicine (35 taxa), feed for cattle (11 taxa), repellent (four taxa), and/or space freshener (two taxa). The most frequently used wild plants are Chamomilla recutita, Mentha x piperita, and Urtica dioica, while Boletus edulis, Agaricus campestris, and Macrolepiota procera are the most often used mushrooms. The results indicate that the local people in the studied north-western part of Croatia still nurture the practice of cultivating and gathering plants and that herbal remedies are considerably important among the informants. The study should be further extended to broaden and preserve valuable ethnobotanical knowledge and encourage the protection of culturally important plants of the studied area.
Sustainable Brand Advertising—The Green Advertising for Generation Z, a Qualitative LRSB Analyze
Authors: Lopes Paula Rosa , Rosário Albérico Travassos , Rosário Filipe Sales
Published: June 2024

Advertising has been one of brands’ main allies in successfully promoting their products and services, creating trends and changing consumer mindsets, which allows them to increase sales and consequently achieve commercial success. The advertising medium has been evolving, increasingly encompassing new technologies as well as expanding its areas of intervention. This research article uses the Systematic Bibliometric Literature Review methodology, and its main objective is to clarify the state of the art regarding advertising and sustainability, since if advertising is one of the main allies for the success of brands, sustainability has become one of its main strategies. The starting question is whether advertising has been used to communicate sustainability. The methodology used in this study is a systematic bibliometric literature review (LRSB) to collect, analyze and synthesize data on advertising and sustainability, and covers a period of publications from the year 2007 to 2024, with the support of visual maps of the research indexed in the Scopus Database, created with VOSViewer. The aim was to give an overview of the studies published in this scientific area. The qualitative results of the analysis suggest that the theme of sustainability has been studied and associated with brands and sectors of activity such as luxury brands. The analysis leads to the suggestion of a reduced connection between sustainability and advertising, with studies on “green advertising” being mentioned, which allows us to affirm that this is an area that requires more in-depth studies, despite the fact that these initial results, on the one hand, help professionals in the field of digital marketing to make decisions, as well as clarifying the topic from a research point of view.
Nitrogen-Blowing Assisted Strategy for Fabricating Large-Area Organic Solar Modules with an Efficiency of 15.6%
Authors: Cheng Yingying , Ji Yitong , Zhang Dongyang , Liu Xiangda , Xia Zezhou , Liu Xiujun , Yang Xueyuan , Huang Wenchao
Published: June 2024

Organic solar cells (OSCs) are one of the most promising photovoltaic technologies due to their affordability and adaptability. However, upscaling is a critical issue that hinders the commercialization of OSCs. A significant challenge is the lack of cost-effective and facile techniques to modulate the morphology of the active layers. The slow solvent evaporation leads to an unfavorable phase separation, thus resulting in a low power conversion efficiency (PCE) of organic solar modules. Here, a nitrogen-blowing assisted method is developed to fabricate a large-area organic solar module (active area = 12 cm2) utilizing high-boiling-point solvents, achieving a PCE of 15.6%. The device fabricated with a high-boiling-point solvent produces a more uniform and smoother large-area film, and the assistance of nitrogen-blowing accelerates solvent evaporation, resulting in an optimized morphology with proper phase separation and finer aggregates. Moreover, the device fabricated by the nitrogen-blowing assisted method exhibits improved exciton dissociation, balanced carrier mobility, and reduced charge recombination. This work proposes a universal and cost-effective technique for the fabrication of high-efficiency organic solar modules.
Adhesion and Transparency Enhancement between Flexible Polyimide-PDMS Copolymerized Film and Copper Foil for LED Transparent Screen
Authors: Wang Xinming , Zhao Yuting , Li Heming , Gao Weiguo , Liu Yan , Sun Anning , Ma Ke , Hu Zhizhi , Wang Yongqi
Published: June 2024

With the increasing demand for innovative electronic products, LED transparent screens are gradually entering the public eye. Polyimide (PI) materials combine high temperature resistance and high transparency, which can be used to prepare flexible copper-clad laminate substrates. The physical and chemical properties of PI materials differ from copper, such as their thermal expansion coefficients (CTEs), surface energy, etc. These differences affect the formation and stability of the interface between copper and PI films, resulting in a short life for LED transparent screens. To enhance PI-copper interfacial adhesion, aminopropyl-terminated polydimethylsiloxane (PDMS) can be used to increase the adhesive ability. Two diamine monomers with a trifluoromethyl structure and a sulfone group structure were selected in this research. Bisphenol type A diether dianhydride is a dianhydride monomer. All three of the above monomers have non−coplanar structures and flexible structural units. The adhesion and optical properties can be improved between the interface of the synthesized PI films and copper foil. PI films containing PDMS 0, 1, 3, and 5 wt% were analyzed using UV spectroscopy. The transmittance of the PI-1/3%, PI-1/5%, PI-2/3%, and PI-2/5% films were all more than 80% at 450 nm. Meanwhile, the Td 5% and Td 10% heat loss and Tg temperatures decreased gradually with the increase in PDMS. The peel adhesion of PI-copper foil was measured using a 180° peel assay. The effect of PDMS addition on peel adhesion was analyzed. PIs-3% films had the greatest peeling intensities of 0.98 N/mm and 0.85 N/mm.
Theory-Driven Tailoring of the Microenvironment of Quaternary Ammonium Binding Sites on Electrospun Nanofibers for Efficient Bilirubin Removal in Hemoperfusion
Authors: Fu Xingyu , Shi Minsi , Chen Dingyang , Zhao Xinyue , Jiang Tingting , Zhao Rui
Published: June 2024

Efficient adsorbents for excess bilirubin removal are extremely important for the treatment of hyperbilirubinemia. However, traditional adsorbents, such as activated carbons and ion-exchange resins, still suffer from dissatisfactory adsorption performance and poor blood compatibility. Herein, we adopted a rational design strategy guided by density functional theory (DFT) calculations to prepare blood-compatible quaternary ammonium group grafted electrospun polyacrylonitrile nanofiber adsorbents. The calculation analysis and adsorption experiments were used to investigate the structure–function relationship between group types and bilirubin adsorption, both indicating that quaternary ammonium groups with suitable configurations played a crucial role in bilirubin binding. The obtained nanofiber adsorbents showed the bilirubin removal efficiency above 90% even at a coexisting BSA concentration of 50 g L−1. The maximum adsorption capacities were 818.9 mg g−1 in free bilirubin solution and 163.7 mg g−1 in albumin bound bilirubin solution. The nanofiber adsorbents also showed considerable bilirubin removal in dynamic adsorption to reduce the bilirubin concentration to a normal level, which was better than commercial activated carbons. Our study demonstrates the high feasibility of a theory-driven design method for the development of grafted electrospun nanofibers, which have good potential as bilirubin adsorbents in hemoperfusion applications.
Decay and Termite Resistance of Wood Modified by High-Temperature Vapour-Phase Acetylation (HTVPA), a Simultaneous Acetylation and Heat Treatment Modification Process
Authors: Wang Zhong-Yao , Xu Jin-Wei , Liu Jian-Wei , Hung Ke-Chang , Wu Tung-Lin , Chang Wen-Shao , Wu Jyh-Horng
Published: June 2024

High-temperature vapour-phase acetylation (HTVPA) is a simultaneous acetylation and heat treatment process for wood modification. This study was the first investigation into the impact of HTVPA treatment on the resistance of wood to biological degradation. In the termite resistance test, untreated wood exhibited a mass loss (MLt) of 20.3%, while HTVPA-modified wood showed a reduced MLt of 6.6–3.2%, which decreased with an increase in weight percent gain (WPG), and the termite mortality reached 95–100%. Furthermore, after a 12-week decay resistance test against brown-rot fungi (Laetiporus sulfureus and Fomitopsis pinicola), untreated wood exhibited mass loss (MLd) values of 39.6% and 54.5%, respectively, while HTVPA-modified wood exhibited MLd values of 0.2–0.9% and −0.2–0.3%, respectively, with no significant influence from WPG. Similar results were observed in decay resistance tests against white-rot fungi (Lenzites betulina and Trametes versicolor). The results of this study demonstrated that HTVPA treatment not only effectively enhanced the decay resistance of wood but also offered superior enhancement relative to separate heat treatment or acetylation processes. In addition, all the HTVPA-modified wood specimens prepared in this study met the requirements of the CNS 6717 wood preservative standard, with an MLd of less than 3% for decay-resistant materials.