bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Polypharmacy and Inappropriate Medication in Adults With Intellectual Disabilities in a Hospital Setting in Switzerland
Authors: Lonchampt Sophie , Gerber Fabienne , Aubry Jean-Michel , Desmeules Jules , Kosel Markus , Besson Marie
Published: June 2021

Background: Polypharmacy and inappropriate prescription are frequent in vulnerable and multi-morbid populations. Adults with intellectual disability (ID) are at risk of being polymedicated because they often present with multiple comorbidities and challenging behaviors.

Aim: The objective of this study was thus to evaluate the prevalence of potentially inappropriate medications (PIM) and polypharmacy in a hospital unit dedicated to adults with ID.

Methods: A 10-month prospective observational study took place at a hospital unit specializing in the care of adults with ID in Geneva, Switzerland. Once a week, health and prescription data were collected and screened for PIM according to preset definitions.

Results: Fourteen patients consented to participate, leading to 20 hospitalization events assessed during the study. Hospitalizations lasted 12.8 weeks on average. ID severities ranged from mild to profound, all degrees of severity being equally represented. One hundred percent of the patients were polymedicated (defined as five drugs or more prescribed simultaneously). A mean number of 9.4 drugs were prescribed per week, including 5.3 psychotropic drugs. The number of prescribed drugs remained stable throughout the hospitalizations. Antipsychotics were the most prescribed drug class (19% of all prescribed drugs), followed by benzodiazepines (13%) and laxatives (12%). A total of 114 PIM were recorded with an average of 5.7 PIM per hospitalization.

Conclusions: This study showed that polypharmacy and inappropriate prescription are very common in adults with ID, even though the literature and expert positions advocate for deprescription in these patients. Specific prescribing and deprescribing guidelines are needed for that specific population.
Psychopathological Symptom Load and Distinguishable Cerebral Blood Flow Velocity Patterns in Patients With Schizophrenia and Healthy Controls: A Functional Transcranial Doppler Study
Authors: Egger Stephan T. , Bobes Julio , Rauen Katrin , Seifritz Erich , Vetter Stefan , Schuepbach Daniel
Published: June 2021

Introduction: Schizophrenia is a severe psychiatric disorder, with executive dysfunction and impaired processing speed playing a pivotal role in the course of the disease. In patients with schizophrenia, neurocognitive deficits appear to be related to alterations in cerebral hemodynamics. It is not fully understood if psychopathological symptom load (i.e., presence and severity of symptoms) is also related to alterations in cerebral hemodynamics. We aim to study the relationship between psychopathological symptom load and cerebral hemodynamics in the Middle Cerebral Artery (MCA) during a cognitive task in patients with schizophrenia and healthy controls.

Methodology: Cerebral hemodynamics in the MCA were examined in 30 patients with schizophrenia and 15 healthy controls using functional Transcranial Doppler (fTCD) during the Trail Making Test (TMT). Psychopathological symptoms were measured using the Brief Psychiatric Rating Scale (BPRS). Patients were dichotomized according to BPRS scores: mild-moderate (BPRS < 41, n = 15) or marked-severe (BPRS ≧ 41, n = 15). Mean blood flow velocity (MFV) in the MCA and processing speed of the TMT were analyzed. Cerebral hemodynamics were analyzed using the general additional model (GAM) with a covariate analysis of variance (ANCOVA) for group comparisons.

Results: Patients and healthy controls were comparable regarding demographics. Patients had a slower processing speed for the TMT-A (patients-severe: 52s, patients-moderate: 40s, healthy-controls: 32s, p = 0.019) and TMT-B [patients-severe: 111s, patients-moderate: 76s, healthy-controls: 66s, p < 0.001)]. Patients demonstrated differing hemodynamic profiles in both TMTs: TMT- A [F(6, 1,792) = 17, p < 0.000); TMT-B [F(6, 2,692) = 61.93, p < 0.000], with a delay in increase in MFV and a failure to return to baseline values.

Conclusions: Patients with schizophrenia demonstrated slower speeds of processing during both the TMT-A and TMT-B. The speed of processing deteriorated with increasing psychopathological symptom load, additionally a distinct cerebral hemodynamic pattern in the MCA was observed. Our results further support the view that severity of schizophrenia, particularly psychopathological symptom load, influences performance in neurocognitive tasks and is related to distinct patterns of brain hemodynamics.
Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive Symptoms
Authors: Bränn Emma , Malavaki Christina , Fransson Emma , Ioannidi Maria-Konstantina , Henriksson Hanna E. , Papadopoulos Fotios C. , Chrousos George P. , Klapa Maria I. , Skalkidou Alkistis
Published: June 2021

Background: Postpartum depression (PPD) is a devastating disease requiring improvements in diagnosis and prevention. Blood metabolomics identifies biological markers discriminatory between women with and those without antenatal depressive symptoms. Whether this cutting-edge method can be applied to postpartum depressive symptoms merits further investigation.

Methods: As a substudy within the Biology, Affect, Stress, Imagine and Cognition Study, 24 women with PPD symptom (PPDS) assessment at 6 weeks postpartum were included. Controls were selected as having a score of ≤ 6 and PPDS cases as ≥12 on the Edinburgh Postnatal Depression Scale. Blood plasma was collected at 10 weeks postpartum and analyzed with gas chromatography–mass spectrometry metabolomics.

Results: Variations of metabolomic profiles within the PPDS samples were identified. One cluster showed altered kidney function, whereas the other, a metabolic syndrome profile, both previously associated with depression. Five metabolites (glycerol, threonine, 2-hydroxybutanoic acid, erythritol, and phenylalanine) showed higher abundance among women with PPDSs, indicating perturbations in the serine/threonine and glycerol lipid metabolism, suggesting oxidative stress conditions.

Conclusions: Alterations in certain metabolites were associated with depressive pathophysiology postpartum, whereas diversity in PPDS physiologies was revealed. Hence, plasma metabolic profiling could be considered in diagnosis and pathophysiological investigation of PPD toward providing clues for treatment. Future studies require standardization of various subgroups with respect to symptom onset, lifestyle, and comorbidities.
Vaccine Information Seeking Behavior Among Pregnant Women in Khartoum State, Sudan: A Hospital-Based Cross-Sectional Study
Authors: Sabahelzain Majdi M. , Ibrahim Zienab A. , Hamad Sahar A. B. , Finnegan Gary
Published: June 2021

Objective: This study aims to explore vaccine information-seeking behavior and its determinants among pregnant women in Khartoum state, Sudan. The findings from this study will be used to inform further development of policies and interventions in Sudan to increase vaccine acceptance and demand.

Methods: A hospital-based cross-sectional study was conducted in two public hospitals, Omdurman maternity and AL-Saudi hospitals in Omdurman, Khartoum state, from February to April 2020.

Results: We interviewed 350 pregnant women in the two hospitals. Our findings showed that one-third of pregnant women (35.7%) searched for information about vaccines. The vast majority searched for this information before pregnancy and during pregnancy (34.4 and 59.2%, respectively). They primarily searched for topics related to vaccine schedules and vaccine side effects (28.8% for each). The main sources of vaccine-related information consumed by pregnant women were healthcare professionals, particularly doctors (40%), and the internet (20.8%). Findings showed that a high level of education was associated with a greater likelihood of searching for additional vaccine information. Moreover, those who perceived their family to have a high income were more likely to search for information. Additionally, pregnant women with low confidence in vaccines were more likely to be involved in searching for additional vaccine information. This highlights the need for high-quality, easily accessible information that addresses their needs.

Conclusion: Our findings showed that confidence in vaccine influences seeking for relevant information. We recommend the development of client-centered communication interventions to help increasing vaccine confidence and consequently vaccine acceptance and demand.
Challenges of Rabies Surveillance in the Eastern Amazon: The Need of a One Health Approach to Predict Rabies Spillover
Authors: Bastos Victor , Mota Roberta , Guimarães Mylenna , Richard Yuri , Lima André Luis , Casseb Alexandre , Barata Gyovanna Corrêa , Andrade Jorge , Casseb Livia Medeiros Neves
Published: June 2021

Brazil has been promoting essential improvements in health indicators by implementing free-access health programs, which successfully reduced the prevalence of neglected zoonosis in urban areas, such as rabies. Despite constant efforts from the authorities to monitor and control the disease, sylvatic rabies is a current issue in Amazon's communities. The inequalities among Amazon areas challenge the expansion of high-tech services and limit the implementation of active laboratory surveillance to effectively avoid outbreaks in human and non-human hosts, which also reproduces a panorama of vulnerability in risk communities. Because rabies is a preventable disease, the prevalence in the particular context of the Amazon area highlights the failure of surveillance strategies to predict spillovers and indicates the need to adapt the public policies to a “One Health” approach. Therefore, this work assesses the distribution of free care resources and facilities among Pará's regions in the oriental Amazon; and discusses the challenges of implanting One Health in the particular context of the territory. We indicate a much-needed strengthening of the sylvatic and urban surveillance networks to achieve the “Zero by 30” goal, which is inextricable from multilateral efforts to combat the progressive biome's degradation.
Physical Therapists as Partners for Community Fall Risk Screenings and Referrals to Community Programs
Authors: Vincenzo Jennifer L. , Hergott Colleen , Schrodt Lori , Perera Subashan , Tripken Jennifer , Shubert Tiffany E. , Brach Jennifer S.
Published: June 2021

Objectives: Physical therapists (PTs) are integral team members in fall prevention in clinical settings; however, few studies have investigated PTs' engagement in pro-bono community-based falls prevention. Therefore, we aimed to describe the characteristics of PTs and physical therapist assistants (PTAs) in the United States who conduct community-based fall screenings, the reach of screenings, their knowledge and utilization of the Centers for Disease Control and Prevention's fall-risk screening toolkit (STEADI, Stopping Elderly Accidents, Deaths, and Injuries), and therapists' knowledge and referrals to evidence-based programs (EBPs) and community resources.

Methods: A cross-sectional survey distributed to a convenience sample of PTs/PTAs in the United States through news-blasts, and social media.

Results: Four hundred and forty-four therapists who worked with older adults completed the survey. Approximately 40% of the respondents (n = 180) conduct screenings, most frequently annually. People who screen tend to be PTs with >20 years of experience, work in outpatient/wellness or academia, and be involved in the least amount of direct patient care. The majority (n = 344, 77.5%) of survey respondents were somewhat to very familiar with the STEADI, and ~84% (n = 114) of respondents who were very familiar with the STEADI (n = 136) use the toolkit to conduct community-based, pro-bono fall risk screenings. Twenty-six percent (n = 14) out of the 53 PTAs who responded to the survey conduct falls screenings in the community. Of the PTs/PTAs who conduct community-based fall screenings (n = 180), ~ 75% (n = 136) are aware of and refer older adults to EBPs. Over half also refer to Silver Sneakers and/or senior centers.

Discussion: PTs and PTAs are key partners in evidence-based multifactorial fall prevention in the community. Data helps inform community organizations that most PTs who engage in community-based fall risk screening utilize the STEADI toolkit and refer to community-based programs. Community organizations seeking PT partners to engage in fall risk screenings and promote referrals to local resources or EBPs will likely have the most success collaborating with local physical therapy education programs or physical therapy clinic managers.
Development of an Asthma Home-Visit Training Program for Community Health Workers and Their Supervisors in Washington State
Authors: Elkugia Nuha , Crocker Mary E. , Stout James W. , Bolt Kaylin , Weiner Bryan J. , Kramer C. Bradley
Published: June 2021

The community health worker (CHW) asthma home-visiting model developed by Public Health-Seattle & King County (PHSKC) is an evidence-based approach proven to improve health outcomes and quality of life. In addition, it has been shown to be an effective and culturally appropriate approach to helping people with asthma understand the environmental and behavioral causes of uncontrolled asthma, while acquiring the skills they need to control their asthma. This paper describes the development and implementation of training curricula for CHWs and supervisors in the asthma home visiting program. To facilitate dissemination, this program took advantage of the current healthcare landscape in Washington State resulting from Centers for Medicare & Medicaid Services (CMS) approval of the 1115 Medicaid Waiver project. Key aspects of the training program development included: (1) Engagement: forming a Community Advisory Board with multiple stakeholders to help prioritize training content; (2) Curriculum Development: building the training on evidence-based home-visit protocols previously developed at PHSKC; (3) Implementation of the training program; (4) Evaluation of the training; and (5) Adaptation of the training based on lessons learned. We describe key factors in the training program's improvement including the use of a community-based participatory approach to engage stakeholders at multiple phases of the project and ensure regional adaption; combining in-person and online modules for delivery; and holding learning collaboratives for post-training and technical support. We also outline our training program evaluation plan and the planned evaluation of the home visit program which the trainees will deliver, both of which follow the RE-AIM framework. However, because the COVID-19 pandemic has curtailed training activities and prohibited the trainees from implementation of these CHW home visit practices, our evaluation is currently incomplete. Therefore, this case study provides insight into the adaptation of the training program, but not the delivery of the home visit program, the outcomes of which remain to be seen.
Willingness to Participate in Alcohol Prevention Interventions Targeting Risky Drinking Employees. The WIRUS Project
Authors: Thørrisen Mikkel Magnus , Bonsaksen Tore , Skogen Jens Christoffer , Skarpaas Lisebet Skeie , Sevic Aleksandra , van Mechelen Willem , Aas Randi Wågø
Published: June 2021

Background: The extent to which eligible individuals in a target population are willing to participate in interventions is important when evaluating the efficacy of public health interventions.

Objectives: As part of a process evaluation of an ongoing randomized controlled trial, this study aimed to identify the proportion of risky drinkers who were willing to participate in an alcohol prevention intervention in an occupational health setting, and correlates for such willingness.

Methods: Risky drinking employees from 22 companies in Norway were identified through an alcohol screening survey. Risky drinkers' (N = 779) willingness to complete a health examination and to be randomized into an alcohol prevention intervention (digital or face-to-face intervention, or control) was recorded by personnel from occupational health services. The proportion of employees who were willing to participate was assessed on 31 potential correlates (sociodemographic, alcohol-related, work-related, and lifestyle/daily activity). Adjusted (multiple logistic regression) analyses were utilized to explore associations between potential correlates and willingness to participate.

Results: Altogether, 38.1% of employees were willing to participate in prevention interventions. In the adjusted analysis, only 5 out of 31 potential correlates were significantly associated with willingness to participate. Managers were more than twice as willing to participate than workers (OR = 2.17, p < 0.01). Willing employees had less workplace decision latitude (perceived control over workplace decisions and less possibility of utilizing personal skills in the job) (OR = 0.62, p < 0.05), and were more overcommitted with exorbitant work ambition and need for approval (OR = 1.49, p < 0.05). Willing employees had to some extent less alcohol-related impaired work performance (presenteeism, OR = 0.78, p < 0.05), and they spent less time on care activities (OR = 0.84, p < 0.05).

Conclusions: Reaching four out of ten with risky drinking habits for prevention interventions strengthens the rationale for targeting this public health problem in occupational health care settings. In particular, this study suggests the importance of ensuring secure commitment among workers, who were less willing til participate than managers. Nevertheless, tailoring recruitment and implementation strategies based on easily identifiable correlates may be onerous.
Surgical Site Infections Are Associated With Higher Blood Loss and Open Access in General Thoracic Practice
Authors: Aeschbacher Pauline , Nguyen Thanh-Long , Dorn Patrick , Kocher Gregor Jan , Lutz Jon Andri
Published: June 2021

Background: Surgical site infections (SSIs) are the most costly and second most frequent healthcare-associated infections in the Western world. They are responsible for higher postoperative mortality and morbidity rates and longer hospital stays. The aim of this study is to analyze which factors are associated with SSI in a modern general thoracic practice.

Methods: Data were collected from our department's quality database. Consecutive patients operated between January 2014 and December 2018 were included in this retrospective study.

Results: A total of 2430 procedures were included. SSIs were reported in 37 cases (1.5%). The majority of operations were video-assisted (64.6%). We observed a shift toward video-assisted thoracic surgery in the subgroup of anatomical resections during the study period (2014: 26.7%, 2018: 69.3%). The multivariate regression analysis showed that blood loss >100 ml (p = 0.029, HR 2.70) and open surgery (p = 0.032, HR 2.37) are independent risk factors for SSI. The latter was higher in open surgery than in video-assisted thoracic procedures (p < 0.001). In the subgroup of anatomical resection, we found the same correlation (p = 0.043). SSIs are also associated with significantly longer mean hospital stays (17.7 vs. 7.8 days, p < 0.001).

Conclusion: As SSIs represent higher postoperative morbidity and costs, efforts should be made to maintain their rate as low as possible. In terms of prevention of SSIs, video-assisted thoracic surgery should be favored over open surgery whenever possible.
High Nitrogen Fertilization Modulates Morpho-Physiological Responses, Yield, and Water Productivity of Lowland Rice under Deficit Irrigation
Authors: Abdou Nasr M. , Abdel-Razek Mohamed A. , Abd El-Mageed Shimaa A. , Semida Wael M. , Leilah Ahmed A. A. , Abd El-Mageed Taia A. Abd , Ali Esmat F. , Majrashi Ali , Rady Mohamed O. A.
Published: June 2021

Sustainability of rice production under flooding conditions has been challenged by water shortage and food demand. Applying higher nitrogen fertilization could be a practical solution to alleviate the deleterious effects of water stress on lowland rice (Oryza sativa L.) in semi-arid conditions. For this purpose, field experiments were conducted during the summer of 2017 and 2018 seasons. These trials were conducted as split-split based on randomized complete blocks design with soil moisture regimes at three levels (120, 100 and 80% of crop evapotranspiration (ETc), nitrogen fertilizers at two levels (N1—165 and N2—200 kg N ha−1) and three lowland Egyptian rice varieties [V1 (Giza178), V2 (Giza177) and V3 (Sakha104)] using three replications. For all varieties, growth (plant height, tillers No, effective tillers no), water status ((relative water content RWC, and membrane stability index, MSI), physiological responses (chlorophyll fluorescence, Relative chlorophyll content (SPAD), and yield were significantly increased with higher addition of nitrogen fertilizer under all water regimes. Variety V1 produced the highest grain yield compared to other varieties and the increases were 38% and 15% compared with V2 and V3, respectively. Increasing nitrogen up to 200 kg N ha−1 (N2) resulted in an increase in grain and straw yields by 12.7 and 18.2%, respectively, compared with N1. The highest irrigation water productivity (IWP) was recorded under I2 (0.89 kg m−3) compared to (0.83 kg m−3) and (0.82 kg m−3) for I1 and I3, respectively. Therefore, the new applied agro-management practice (deficit irrigation and higher nitrogen fertilizer) effectively saved irrigation water input by 50–60% when compared with the traditional cultivation method (flooding system). Hence, the new proposed innovative method for rice cultivation could be a promising strategy for enhancing the sustainability of rice production under water shortage conditions.
Nitrogen Balance in a Sweet Sorghum Crop in a Mediterranean Environment
Authors: Scordia Danilo , Cosentino Salvatore Luciano , Mantineo Mariadaniela , Testa Giorgio , Patanè Cristina
Published: June 2021

Sweet sorghum is a C4 plant with great biomass potential yield in semi-arid environments. Under growing conditions affected by water shortage and nutrient deficiency, the optimal combination of irrigation and nitrogen (N) fertilization rate is a central issue for sustainable farming systems. In this paper, a N balance study was applied to sweet sorghum cv. Keller, managed under three irrigation levels (I0, I50, I100: 0, 50, and 100% crop evapotranspiration—ETc restoration) and four N-fertilization rates (N0, N60, N120, N180: 0, 60, 120, and 180 kg ha−1). The 15N-labelled fertilization technique was used to assess the fate of N fertilizer within the agroecosystem. Dry biomass yield was significantly affected by the irrigation, while N rates had no effect. Across N and irrigation levels, the isotopic composition showed that approximately 34% of N applied by fertilization was used by the crop, 56% remained in the soil at the end of the cropping season, 1.83% was leached as nitrate, and 1.72% was volatilized as ammonia. N-fertilizer uptake was the lowest in I0, while in N0, the soil was strongly N-impoverished since sorghum showed a great aptitude to benefit from the soil N reserve. An even N input/output system (i.e., N-output corresponded to N-input) was observed in the N120 treatment, and the soil N reserve remained unchanged, while the system was N-enriched (positive input/output) in N180. However, although beneficial for crop nutrition and soil N reserve for subsequent crops in rotation, the N180 treatment is unsustainable due to many environmental side effects in the agroecosystem.
Plasmid-Mediated Antibiotic Resistant Escherichia coli in Sarawak Rivers and Aquaculture Farms, Northwest of Borneo
Authors: Lihan Samuel , Lee Sai Y. , Toh Seng C. , Leong Sui S.
Published: June 2021

Background: The emergence of plasmid-mediated antibiotic resistance in Escherichia coli in water resources could pose a serious threat to public health. The study aims to investigate the dispersion of plasmid-mediated antibiotic-resistant E. coli from six rivers in Sarawak and two aquaculture farms in Borneo. Methods: A total of 74 water samples were collected for the determination of their bacteria colony count. An IMViC test identified 31 E. coli isolates and tested their susceptibility against twelve clinically important antibiotics. The extraction of plasmid DNA was done using alkali lysis SDS procedures. Characteristics, including plasmid copy number, molecular weight size, resistance rate and multiple antibiotic resistance (MAR), were assessed. Results: Our findings revealed that bacterial counts in rivers and aquaculture farms ranged from log 2.00 to 3.68 CFU/mL and log 1.70 to 5.48 cfu/mL, respectively. Resistance to piperacillin (100%) was observed in all E. coli; resistance to amoxicillin (100%) and ampicillin (100%) was observed in E. coli found in aquaculture farms; resistance to streptomycin (93%) was observed in E. coli found in rivers. All E. coli were resistant to ≥2 antibiotics and formed 26 MAR profiles, ranging from an index of 0.17 to 0.83, indicating that there are high risks of contamination. Some (48.4%) of the E. coli were detected with plasmids (1.2 to >10 kb), whereas 51.6% of the E. coli did not harbor any plasmids. The plasmid copy numbers reported were one plasmid (n = 7), two plasmids (n = 4), ≥ two plasmids (4). E. coli isolated from the Muara Tuang River showed the highest-molecular-weight plasmids. A statistical analysis revealed that there is no significant correlation (r = 0.21, p = 0.253) between the number of plasmids and the MAR index of the tested isolates. Conclusion: The distribution of MAR in E. coli from rivers is higher compared to the aquaculture environment. Our study suggests that MAR in isolates could be chromosome-mediated. Our results suggest that riverbed sediments could serve as reservoirs for MAR bacteria, including pathogens, under different climatic conditions, and their analysis could provide information for public health concerns.
Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials
Authors: Hanna Reem , Dalvi Snehal , Bensadoun René Jean , Benedicenti Stefano
Published: June 2021

This systematic review and meta-analysis (PROSPERO registration; ref CRD 42020198921) aimed to govern photobiomodulation therapy (PBMT) efficacy in temporomandibular disorder (TMD). PRISMA guidelines and Cochrane Collaboration recommendations were followed. Differences in pain reduction assessment by qualitative measurement with visual analogue scale (VAS), pain pressure threshold (PPT) and maximum mouth opening (MMO) were calculated with 95% confidence intervals and pooled in a random effects model with a subgroup analysis, evaluating the role of follow-up duration. Heterogeneity was analysed using Q and I2 tests. Publication bias was assessed by visual examination of funnel plot symmetry. Qualitative analysis revealed 46% of the 44 included studies showed a high risk of bias. Meta-analysis on 32 out of 44 studies revealed statistically significant intergroup differences (SSID) for VAS (SMD = −0.55; 95% CI = −0.82 to −0.27; Z = 3.90 (p < 0.001)), PPT (SMD = −0.45; 95% CI = −0.89 to 0.00; Z = 1.97 (p = 0.05)) and MMO (SMD = −0.45; 95% CI = −0.89 to 0.00; Z = 1.97 (p = 0.05)), favouring PBMT compared to control treatment strategies. Sensitivity analysis revealed SSID (SMD = −0.53; 95% CI = −0.73 to −0.32; Z = 5.02 (p < 0.0001)) with low heterogeneity (Τ2 = 0.02; χ2 = 16.03 (p = 0.31); I2 = 13%). Hence, this review, for first time, proposed suggested recommendations for PBMT protocols and methodology for future extensive TMD research.
Effect of Photosensitization Mediated by Curcumin on Carotenoid and Aflatoxin Content in Different Maize Varieties
Authors: Nguenha Rafael , Damyeh Maral Seidi , Phan Anh D. T. , Hong Hung T. , Chaliha Mridusmita , O’Hare Tim J. , Netzel Michael E. , Sultanbawa Yasmina
Published: June 2021

Mycotoxins are naturally occurring toxins produced by certain types of fungi that contaminate food and feed, posing serious health risks to human and livestock. This study evaluated the combination of blue light with curcumin to inactivate Aspergillus flavus spores, its effect on aflatoxin B1 (AFB1) production and maintaining carotenoid content in three maize varieties. The study was first conducted in vitro, and the spore suspensions (104 CFU·mL−1) were treated with four curcumin concentrations (25 and 50 µM in ethanol, 1000 and 1250 µM in propylene glycol) and illuminated at different light doses from 0 to 130.3 J·cm−2. The photoinactivation efficiency was light-dose dependent with the highest photoinactivation of 2.3 log CFU·mL−1 achieved using 1000 µM curcumin at 104.2 J·cm−2. Scanning electron microscopy revealed cell wall deformations as well as less density in photosensitized cells. Photosensitization of maize kernels gave rise to a complete reduction in the viability of A. flavus and therefore inhibition of AFB1 production, while no significant (p > 0.05) effect was observed using either light or curcumin. Moreover, photosensitization did not affect the carotenoids in all the studied maize varieties. The results suggest that photosensitization is a green alternative preservation technique to decontaminate maize kernels and reduce consumer exposure to AFB1 without any effect on carotenoid content.
Study on the Progressive Deterioration of Tunnel Lining Structures in Cold Regions Experiencing Freeze–Thaw Cycles
Authors: Xu Peng , Wu Yimin , Huang Le , Zhang Kun
Published: June 2021

The linings of tunnels in cold regions with long service lives usually have cracks, with parts of the structure peeling and falling off, which seriously threatens the tunnel safety and operation. The unsaturated freeze–thaw cycle of concrete, which is the main cause of structural deterioration, has not received much research attention. During the service life of tunnels in cold regions, unsaturated freeze–thaw cycles deteriorate the quality of the concrete, and its degree presents a gradual distribution in the circumferential and longitudinal directions. An experiment system was adopted to simulate the distribution of the progressive deterioration of tunnel lining concrete. The test results of the temperature field of the model show the distribution law of freeze–thaw cycles, and the gradual deterioration of the lining concrete was realized. Then, the bearing capacity of the model was tested after the progressive deterioration. The results show that the ultimate load of the model decreases with an increase in the number of freeze–thaw cycles. Finally, a numerical simulation was carried out to discuss the influence of the gradual deterioration of the lining. The gradual deterioration of lining concrete will encourage the gradual development of cracks, leading to serious cracking of the lining structure and even block spalling. Through this study, we hope to provide useful information for the prevention and control of tunnel frost damage in cold regions.
Agricultural Residue Management for Sustainable Power Generation: The Poland Case Study
Authors: Havrysh Valerii , Kalinichenko Antonina , Brzozowska Anna , Stebila Jan
Published: June 2021

The European Union has set targets for renewable energy utilization. Poland is a member of the EU, and its authorities support an increase in renewable energy use. The background of this study is based on the role of renewable energy sources in improving energy security and mitigation of climate change. Agricultural waste is of a significant role in bioenergy. However, there is a lack of integrated methodology for the measurement of its potential. The possibility of developing an integrated evaluation methodology for renewable energy potential and its spatial distribution was assumed as the hypothesis. The novelty of this study is the integration of two renewable energy sources: crop residues and animal husbandry waste (for biogas). To determine agricultural waste energy potential, we took into account straw requirements for stock-raising and soil conservation. The total energy potential of agricultural waste was estimated at 279.94 PJ. It can cover up to 15% of national power generation. The spatial distribution of the agricultural residue energy potential was examined. This information can be used to predict appropriate locations for biomass-based power generation facilities. The potential reduction in carbon dioxide emissions ranges from 25.7 to 33.5 Mt per year.
The Effects of Compression on the Detection of Atrial Fibrillation in ECG Signals
Authors: Cervigón Raquel , McGinley Brian , Craven Darren , Glavin Martin , Jones Edward
Published: June 2021

Although Atrial Fibrillation (AF) is the most frequent cause of cardioembolic stroke, the arrhythmia remains underdiagnosed, as it is often asymptomatic or intermittent. Automated detection of AF in ECG signals is important for patients with implantable cardiac devices, pacemakers or Holter systems. Such resource-constrained systems often operate by transmitting signals to a central server where diagnostic decisions are made. In this context, ECG signal compression is being increasingly investigated and employed to increase battery life, and hence the storage and transmission efficiency of these devices. At the same time, the diagnostic accuracy of AF detection must be preserved. This paper investigates the effects of ECG signal compression on an entropy-based AF detection algorithm that monitors R-R interval regularity. The compression and AF detection algorithms were applied to signals from the MIT-BIH AF database. The accuracy of AF detection on reconstructed signals is evaluated under varying degrees of compression using the state-of-the-art Set Partitioning In Hierarchical Trees (SPIHT) compression algorithm. Results demonstrate that compression ratios (CR) of up to 90 can be obtained while maintaining a detection accuracy, expressed in terms of the area under the receiver operating characteristic curve, of at least 0.9. This highlights the potential for significant energy savings on devices that transmit/store ECG signals for AF detection applications, while preserving the diagnostic integrity of the signals, and hence the detection performance.
Ensuring Agricultural Sustainability through Remote Sensing in the Era of Agriculture 5.0
Authors: Martos Vanesa , Ahmad Ali , Cartujo Pedro , Ordoñez Javier
Published: June 2021

Timely and reliable information about crop management, production, and yield is considered of great utility by stakeholders (e.g., national and international authorities, farmers, commercial units, etc.) to ensure food safety and security. By 2050, according to Food and Agriculture Organization (FAO) estimates, around 70% more production of agricultural products will be needed to fulfil the demands of the world population. Likewise, to meet the Sustainable Development Goals (SDGs), especially the second goal of “zero hunger”, potential technologies like remote sensing (RS) need to be efficiently integrated into agriculture. The application of RS is indispensable today for a highly productive and sustainable agriculture. Therefore, the present study draws a general overview of RS technology with a special focus on the principal platforms of this technology, i.e., satellites and remotely piloted aircrafts (RPAs), and the sensors used, in relation to the 5th industrial revolution. Nevertheless, since 1957, RS technology has found applications, through the use of satellite imagery, in agriculture, which was later enriched by the incorporation of remotely piloted aircrafts (RPAs), which is further pushing the boundaries of proficiency through the upgrading of sensors capable of higher spectral, spatial, and temporal resolutions. More prominently, wireless sensor technologies (WST) have streamlined real time information acquisition and programming for respective measures. Improved algorithms and sensors can, not only add significant value to crop data acquisition, but can also devise simulations on yield, harvesting and irrigation periods, metrological data, etc., by making use of cloud computing. The RS technology generates huge sets of data that necessitate the incorporation of artificial intelligence (AI) and big data to extract useful products, thereby augmenting the adeptness and efficiency of agriculture to ensure its sustainability. These technologies have made the orientation of current research towards the estimation of plant physiological traits rather than the structural parameters possible. Futuristic approaches for benefiting from these cutting-edge technologies are discussed in this study. This study can be helpful for researchers, academics, and young students aspiring to play a role in the achievement of sustainable agriculture.
Applicability of Semi-Quantitative Evaluation of the Intercondylar Notch
Authors: Hirtler Lena , Tschematschar Katrin , Kainberger Franz , Röhrich Sebastian
Published: June 2021

The intercondylar notch (IN) can differ in morphology and size, influencing the contained ligaments. For a better understanding of the influence of the IN’s anatomy on knee pathologies, a classification of different shapes was proposed. However, a detailed evaluation of the reliability of these classifications is lacking thus far. In coronal knee MRIs of 330 patients, the IN width was measured and three shapes were calculated to generate objective control results. Notch shapes were classified by two blinded investigators, first without and then with visual assistance to guide the shape classification. The distribution of the three different shapes was as follows: A-shape: n = 43, 13.0%; inverse U-shape: n = 100, 30.3%; Ω-shape: n = 183, 56.7%. The semi-quantitative evaluation distribution was as follows: A-shape: n = 44, 13.3%; inverse U-shape: n = 37, 11.2%; Ω-shape: n = 249, 75%; there was fair (κ = 0.35) agreement compared to that of the control results. The assisted semi-quantitative evaluation distribution was as follows: A-shape: n = 44, 13.3%; inverse U-shape: 103, 31.2%; Ω-shape: n = 183, 55.3%; there was very good (κ = 0.92) agreement compared to that of the control results. In the shape evaluation of the IN, rigid guidelines and visual assistance must be used to ensure reliability. The utilization of visual assistance led to higher inter- and intra-rater agreements in the semi-quantitatively evaluation of the IN shape when compared to those in the classification without visual assistance.
Acoustic Characterization of Some Steel Industry Waste Materials
Authors: Levi Elisa , Sgarbi Simona , Piana Edoardo Alessio
Published: June 2021

From a circular economy perspective, the acoustic characterization of steelwork by-products is a topic worth investigating, especially because little or no literature can be found on this subject. The possibility to reuse and add value to a large amount of this kind of waste material can lead to significant economic and environmental benefits. Once properly analyzed and optimized, these by-products can become a valuable alternative to conventional materials for noise control applications. The main acoustic properties of these materials can be investigated by means of a four-microphone impedance tube. Through an inverse technique, it is then possible to derive some non-acoustic properties of interest, useful to physically characterize the structure of the materials. The inverse method adopted in this paper is founded on the Johnson–Champoux–Allard model and uses a standard minimization procedure based on the difference between the sound absorption coefficients obtained experimentally and predicted by the Johnson–Champoux–Allard model. The results obtained are consistent with other literature data for similar materials. The knowledge of the physical parameters retrieved applying this technique (porosity, airflow resistivity, tortuosity, viscous and thermal characteristic length) is fundamental for the acoustic optimization of the porous materials in the case of future applications.
Recurrent Neural Network Based Short-Term Load Forecast with Spline Bases and Real-Time Adaptation
Authors: Yuan Tzu-Lun , Jiang Dian-Sheng , Huang Shih-Yun , Hsu Yuan-Yu , Yeh Hung-Chih , Huang Mong-Na Lo , Lu Chan-Nan
Published: June 2021

Short-term load forecast (STLF) plays an important role in power system operations. This paper proposes a spline bases-assisted Recurrent Neural Network (RNN) for STLF with a semi-parametric model being adopted to determine the suitable spline bases for constructing the RNN model. To reduce the exposure to real-time uncertainties, interpolation is achieved by an adapted mean adjustment and exponentially weighted moving average (EWMA) scheme for finer time interval forecast adjustment. To circumvent the effects of forecasted apparent temperature bias, the forecasted temperatures issued by the weather bureau are adjusted using the average of the forecast errors over the preceding 28 days. The proposed RNN model is trained using 15-min interval load data from the Taiwan Power Company (TPC) and has been used by system operators since 2019. Forecast results show that the spline bases-assisted RNN-STLF method accurately predicts the short-term variations in power demand over the studied time period. The proposed real-time short-term load calibration scheme can help accommodate unexpected changes in load patterns and shows great potential for real-time applications.
Proteo: A Framework for Serious Games in Telerehabilitation
Authors: Bernava Giuseppe , Nucita Andrea , Iannizzotto Giancarlo , Caprì Tindara , Fabio Rosa Angela
Published: June 2021

Within the context of telerehabilitation, serious games have a significant role, but creating software for serious games is resource demanding. We present Proteo, a modular and open-source framework for developing serious games from scratch. We also present two serious game implementation examples with analysis of end user and therapist/researcher satisfaction. By involving a group of 11 specialized therapists and 9 end users we analyzed the Proteo’s user satisfaction. We found that both groups scored high for the level of involvement, and the therapists scored also high for the level of suitability. More in depth, both groups showed significant differences between positive and negative feelings, with positive feelings scoring higher than negative ones. Finally, the user level of suitability was reported as high while the difficulty of the system and the difficulty of the task were reported as low. Proteo has proven to be a useful tool to develop serious games for telerehabilitation and has been well accepted by the users involved in the evaluation tests.
The Sperm Structure and Spermatogenesis of Trypophloeus klimeschi (Coleoptera: Curculionidae: Scolytinae)
Authors: Gao Jing , Gao Guanqun , Wang Jiaxing , Chen Hui
Published: June 2021

The male reproductive system, sperm structure, and spermatogenesis of Trypophloeusklimeschi (Coleoptera: Curculionidae: Scolytinae), which is one of the most destructive pests of Populus alba var. pyramidalis (Bunge), were investigated using light microscopy, scanning electron microscopy, and transmission electron microscopy. The male reproductive system of T.klimeschi is composed of testes, seminal vesicles, tubular accessory glands, multilobulated accessory glands, vasa deferentia, and a common ejaculatory duct. In spermatogenesis, two phenomena are apparent: The nuclear chromatin condenses into two different patterns, and an oval preacrosomal vesicle is present at the flank of the Golgi apparatus. The sperm are short, measuring 76.7 ± 1.8 μm in length, and are 508.1 ± 12.9 nm in width. The sperm are composed of a three-layer acrosomal complex, a cylindrical nucleus, two mitochondrial derivatives, a 9 + 9 + 2 axoneme, and two accessory bodies with a large “puff”-like expansion. Mature sperm are individually stored in seminal vesicles. During spermiogenesis, the similarities in the nuclear chromatin condensation characteristics of Curculioninae and Scolytinae are indicative of their close phylogenetic relationship. It appears that the preacrosomal vesicle being flanked by the Golgi apparatus is a characteristic of spermatogenesis in Curculionidae.
Interhelical H-Bonds Modulate the Activity of a Polytopic Transmembrane Kinase
Authors: Almada Juan Cruz , Bortolotti Ana , Ruysschaert Jean Marie , de Mendoza Diego , Inda María Eugenia , Cybulski Larisa Estefanía
Published: June 2021

DesK is a Histidine Kinase that allows Bacillus subtilis to maintain lipid homeostasis in response to changes in the environment. It is located in the membrane, and has five transmembrane helices and a cytoplasmic catalytic domain. The transmembrane region triggers the phosphorylation of the catalytic domain as soon as the membrane lipids rigidify. In this research, we study how transmembrane inter-helical interactions contribute to signal transmission; we designed a co-expression system that allows studying in vivo interactions between transmembrane helices. By Alanine-replacements, we identified a group of polar uncharged residues, whose side chains contain hydrogen-bond donors or acceptors, which are required for the interaction with other DesK transmembrane helices; a particular array of H-bond- residues plays a key role in signaling, transmitting information detected at the membrane level into the cell to finally trigger an adaptive response.
A New Pentafluorothio-Substituted Curcuminoid with Superior Antitumor Activity
Authors: Linder Benedikt , Köhler Leonhard H. F. , Reisbeck Lisa , Menger Dominic , Subramaniam Dharmalingam , Herold-Mende Christel , Anant Shrikant , Schobert Rainer , Biersack Bernhard , Kögel Donat
Published: June 2021

A new and readily available pentafluorothiophenyl-substituted N-methyl-piperidone curcuminoid 1a was prepared and investigated for its anti-proliferative, pro-apoptotic and cancer stem cell-differentiating activities against a panel of human tumor cell lines derived from various tumor entities. The compound 1a was highly anti-proliferative and reached IC50 values in the nanomolar concentration range. 1a was superior to the known anti-tumorally active curcuminoid EF24 (2) and its known N-ethyl-piperidone analog 1b in all tested tumor cell lines. Furthermore, 1a induced a noticeable increase of intracellular reactive oxygen species in HT-29 colon adenocarcinoma cells, which possibly leads to a distinct increase in sub-G1 cells, as assessed by cell cycle analysis. A considerable activation of the executioner-caspases 3 and 7 as well as nuclei fragmentation, cell rounding, and membrane protrusions suggest the triggering of an apoptotic mechanism. Yet another effect was the re-organization of the actin cytoskeleton shown by the formation of stress fibers and actin aggregation. 1a also caused cell death in the adherently cultured glioblastoma cell lines U251 and Mz54. We furthermore observed that 1a strongly suppressed the stem cell properties of glioma stem-like cell lines including one primary line, highlighting the potential therapeutic relevance of this new compound.
RSK Isoforms in Acute Myeloid Leukemia
Authors: Youn Minyoung , Gomez Jesus Omar , Mark Kailen , Sakamoto Kathleen M.
Published: June 2021

Ribosomal S6 Kinases (RSKs) are a group of serine/threonine kinases that function downstream of the Ras/Raf/MEK/ERK signaling pathway. Four RSK isoforms are directly activated by ERK1/2 in response to extracellular stimuli including growth factors, hormones, and chemokines. RSKs phosphorylate many cytosolic and nuclear targets resulting in the regulation of diverse cellular processes such as cell proliferation, survival, and motility. In hematological malignancies such as acute myeloid leukemia (AML), RSK isoforms are highly expressed and aberrantly activated resulting in poor outcomes and resistance to chemotherapy. Therefore, understanding RSK function in leukemia could lead to promising therapeutic strategies. This review summarizes the current information on human RSK isoforms and discusses their potential roles in the pathogenesis of AML and mechanism of pharmacological inhibitors.