bluuebunny/crossref_metadata_2025 huggingface dataset:
Glycemic and Psychosocial Outcomes of Advanced Hybrid Closed Loop Therapy in Youth with High HbA1c: A Randomized Clinical Trial
Authors: B Abraham Mary , J Smith Grant , Dart Julie , Clarke Antony D. , Bebbington Keely , M Fairchild Janice , R Ambler Geoffrey , J Cameron Fergus , A. Davis Elizabeth , W Jones Timothy
Published: September 2024

Objective

To determine the efficacy of advanced hybrid closed loop (AHCL) therapy in a high-risk cohort of youth on continuous subcutaneous insulin infusion (CSII)+/-continuous glucose monitoring (CGM) with suboptimal glycemia.

Research Design and Methods

In a 6-month multicentre clinical trial, youth with type 1 diabetes with mean and most recent HbA1c > 8.5%(65mmol/mol) were randomly assigned 1:1 to AHCL or treatment as usual (CSII+/-CGM). The primary outcome was the 24-week between-group difference in HbA1c. Secondary outcomes included CGM metrics from masked CGM and psychological measures (youth-reported problem areas in diabetes (PAID), quality of life, anxiety, depression and hypoglycemia fear) assessed using validated questionnaires.

Results

A total of 42 participants were randomized [mean(SD) age 16.2(2.5) years, HbA1c 9.8 (1.1)% or 84(12)mmol/mol, PAID score 50.3(19.8)]. At study end, the mean (SD) HbA1c was 8.8(1.1)% or 73(12)mmol/mol with AHCL and 9.9(1.2)% or 85(13.1)mmol/mol with CSII ± CGM, with mean adjusted group difference of -0.77%(95% CI,-1.45 to -0.09) or -8.4 mmol/mol(-15.8 to -1.0)];p=0.027). AHCL increased time in range 70-180 mg/dl (difference 19.1%; 95% CI, 11.1 to 27.1), reduced time >180 mg/dl (difference -17.7 %; 95% CI,-26.6 to -8.8), with no increase in time spent <70 mg/dl (difference -0.8%; 95% CI,-2.7 to 0.6). There was no evidence for difference in psychosocial outcomes between the two groups at study end.

Conclusions

AHCL should be encouraged in youth with suboptimal glycemia as AHCL improves glycemia. However, psychological support remains vital as technology alone may not be able to reduce the burden of diabetes care in this subgroup.
Risk of Severe Hypoglycemia After Initiation of Noninsulin Glucose-Lowering Therapies in Adults With Type 2 Diabetes at Moderate Cardiovascular Disease Risk
Authors: G. McCoy Rozalina , Sindhu Swarna Kavya , J. Neumiller Joshua , C. Polley Eric , Deng Yihong , M. Mickelson Mindy
Published: September 2024

In this emulated comparative effectiveness target trial of glucagon-like peptide 1 (GLP-1) receptor agonist, sodium–glucose cotransporter 2 (SGLT2) inhibitor, dipeptidyl peptidase 4 (DPP-4) inhibitor, and sulfonylurea therapy among adults with type 2 diabetes at moderate cardiovascular disease risk, sulfonylurea use was associated with a significantly higher risk of hypoglycemia requiring emergency department or hospital care than treatment with DPP-4 inhibitors, GLP-1 receptor agonists, or SGLT2 inhibitors. This consideration can guide the choice of glucose-lowering therapy in this highly prevalent patient population, in whom avoidance of hypoglycemia is important, yet among whom the risk of severe hypoglycemia has not been examined previously.
A systematic review of crosswalks for converting patient-reported outcome measure scores in hip, knee, and shoulder replacement surgery
Authors: Ackerman Ilana N , Soh Sze-Ee , Hallstrom Brian R , Fang Yi Ying , Franklin Patricia , Lützner Jörg , Ingelsrud Lina Holm
Published: September 2024

Background and purpose: We aimed to systematically review studies of crosswalks for converting patient-reported outcome measure (PROM) scores used in joint replacement, and develop a database of published crosswalks.Methods: 4 electronic databases were searched from January 2000 to May 2023 to identify studies reporting the development and/or validation of crosswalks to convert PROM scores in patients undergoing elective hip, knee, or shoulder replacement surgery. Data on study and sample characteristics, source and target PROMs, and crosswalk development and validation methods were extracted from eligible studies. Study reporting was evaluated using the Mapping onto Preference-based measures reporting Standards (MAPS) checklist.Results: 17 studies describing 35 crosswalks were eligible for inclusion. Unidirectional crosswalks were available to convert hip-specific (Oxford Hip Score [OHS]) and knee-specific (Oxford Knee Score [OKS]) scores to the EQ-5D-3L/EQ-5D-5L. Similar crosswalks to convert disease-specific scores (WOMAC) to the EQ-5D-3L, EQ-5D-5L, and ICECAP-O Capability Index were identified. Bidirectional crosswalks for converting OHS and OKS to the HOOS-JR/HOOS-12 and KOOS-JR/KOOS-12, for converting WOMAC to the HOOS-JR/KOOS-JR, and for converting HOOS-Function/KOOS-Function to the PROMIS-Physical Function were also available. Additionally, crosswalks to convert generic PROM scores from the UCLA Activity Scale to the Lower Extremity Activity Scale in both directions were available. No crosswalks were identified for converting scores in shoulder replacement. Development methods varied with the type of target score; most studies used regression, item response theory, or equipercentile equating approaches. Reporting quality was variable, particularly for methods and results items, impacting crosswalk application.Conclusion: This is the first synthesis of published crosswalks for converting joint-specific (OHS, OKS, HOOS, KOOS), disease-specific (WOMAC), and generic PROMs scores (PROMIS-Physical Function, UCLA Activity Scale, Lower Extremity Activity Scale) used to assess joint replacement outcomes, providing a resource for data harmonization and pooled analysis. Crosswalks were developed using regression methods (9 studies), equipercentile equating methods (5 studies), a combination of equipercentile equating and item response theory methods (2 studies), and a combination of regression and equipercentile equating methods (1 study). A range of crosswalk validation approaches were adopted, including the use of external datasets, separate samples or subsets, follow-up data from additional time points, or bootstrapped samples. Efforts are needed to standardize crosswalk methodology and achieve consistent reporting.
Urinary stone assessment in a single-phase may replace the unenhanced and multiphase computed tomography protocol in painless visible haematuria
Authors: Galtung Kristina Flor , Lauritzen Peter Mæhre , Sandbæk Gunnar , Bay Dag , Baco Eduard , Rud Erik
Published: September 2024

Objective: Painless visible haematuria (VH) necessitates a computed tomography (CT) usually consisting of one unenhanced and two to three contrast enhanced acquisitions to detect urinary tract stones and malignancy. Recently, we demonstrated that a single nephrographic phase (NP) CT sufficed in detecting malignancy in patients with painless VH. Now, we aim to evaluate the diagnostic performance of single NP CT in stone detection and size measurements in the same cohort.
Material and methods: “A Prospective Trial for Examining Haematuria using Computed Tomography” (PROTEHCT) was a single-center prospective diagnostic study in patients with painless VH between September 2019 and June 2021. All underwent four-phase CT (reference standard) from which a single NP CT (experimental) was extracted. Two randomised readers independently assessed the experimental CT for urinary stones and size. Statistical analysis included diagnostic accuracies and inter-reader agreement (kappa) of experimental CT, and size correlation (Spearman’s ρ) between experimental CT and reference standard.
Results: In 308 included patients (median age: 68 years, 250 males), urinary stones (median size 5 mm) were diagnosed in 21%. The per-patient experimental CT sensitivity was 86% (97% for stones ≥ 5 mm), specificity was 98% and accuracy was 96%. The experimental CT sensitivity for detecting kidney stones was 78% (89% for stones ≥ 5 mm), and 100% for bladder and ureteral stones. No missed stone required active treatment. The inter-reader agreement was almost perfect (96%, k = 0.85). The correlation in stone size was very strong (ρ = 0.91). 
Conclusions: A single NP CT is sufficient in detecting and measuring urinary stones in patients with painless VH.
Determinantes sociais de saúde e internações de crianças de zero a quatro anos por COVID-19 no Nordeste brasileiro
Authors: Fontenele Maria Gabriela Miranda , Santos Daisyanne Augusto de Sales , Bessa Cristina Costa , Almeida Paulo César de , Barbosa Lorena Pinheiro , Lima Francisca Elisângela Teixeira , Cardoso Maria Vera Lúcia Moreira Leitão , Guedes Nirla Gomes
Published: September 2024

Objetivo: analisar a associação entre determinantes sociais e morbidades para os desfechos por COVID-19 relacionados à internação, internação em UTI e óbito em crianças de zero a quatro anos no Nordeste brasileiro. Metodologia: trata-se de um estudo quantitativo, documental, de casos notificados referentes à internação hospitalar por COVID-19 em crianças de zero a quatro anos de idade entre 13 de março de 2020 e 19 de junho de 2021. A coleta de dados foi realizada mediante consulta à base de dados secundária de acesso público. Totalizaram-se 2.039 casos de COVID-19 confirmados nos estados da Região Nordeste do Brasil. Resultados: predominância de crianças do sexo masculino (58,1%), com idade de um ano (56,8%), cor de pele parda (83,3%), com uma morbidade preexistente (70,0%) e multimorbidades (24,5%). Houve associação entre os determinantes sociais da saúde e as morbidades que apresentaram significância: idade e internação em UTI, idade e desfecho de óbito, morbidade e evolução para internação em UTI. Conclusão: os resultados do estudo contribuem para o planejamento de estratégias em saúde e políticas públicas para redução de internações e óbito por COVID-19.
MIGRATION OF SERVICES IN A KUBERNETES CLUSTER BASED ON WORKLOAD FORECASTING
Authors:   Lviv Polytechnic National University, Fedoryshyn B. , Krasko O.
Published: September 2024

The article delves into the intricate challenge of scaling microservices within a Kubernetes cluster, thoroughly examining existing methodologies for scaling microservice architectures, and presenting a novel approach that involves migrating specific components. Unlike the conventional horizontal and vertical scaling strategies, which require additional resources, this proposed method focuses on migrating non-critical components to another Kubernetes cluster. This migration effectively frees up resources in the cluster experiencing increased load without necessitating extra resources, thus significantly reducing maintenance costs through lower server rental expenses. Furthermore, a detailed comparative analysis of reactive and proactive decision-making approaches for system scaling was conducted, with a preference shown for the proactive approach. Unlike the reactive method, where scaling is a response to an increase in load, the proactive approach relies on forecasted data to make scaling decisions before the actual load rises, thereby maintaining a high quality of service (QoS). To identify the most optimal load forecasting method, various models were reviewed and practically compared, including ARIMA, Prophet, and LSTM models. ARIMA was ultimately selected for implementing the proposed approach, realized as a Docker container with a Python application. This application retrieves system data from the Prometheus database and utilizes the ARIMA model for forecasting. Post-forecasting, it updates the deployment configuration files for ArgoCD and commits the changes to a Git repository. Once the updated configuration files are pushed to the Git repository, ArgoCD fetches the new configuration, compares it with the current deployment, and if there are discrepancies, automatically adjusts the infrastructure to the desired state. This approach not only optimizes resource usage within the Kubernetes cluster but also maintains high performance without incurring additional costs.
Co-design, with two South African villages, of a prototype for an e-waste management mobile app
Authors: Gazana Odwa , Ngqondi Thembisa Grace
Published: September 2024

Electronic waste (e-waste) contains toxic elements that, if not carefully disposed of, can harm the environment and human health. It is imperative that e-waste is handled in a correct, safe manner. The study engaged with two rural South African villages, Mantunzeleni and Mpeta in the Eastern Cape Province, to determine their current e-waste disposal practices and to co-design a cloud-based mobile application (app) for improved e-waste management. Twenty-six participants, 13 from each village, participated in the study. A focus group discussion with participants explored the communities’ existing e-waste disposal behaviours, which were found to be harmful to the environment. Participants were then introduced to, and guided through, the co-design process, which resulted in development of a prototype cloud-based mobile app that would, if implemented, allow households to request the collection of e-waste items by the local municipality. The authors argue that, because of the co- design process, the app (if implemented by the municipality) will be well-suited to the needs of, and widely used by, the two target communities, who will feel a sense of ownership of the technological solution that they helped to create.
Non-compliant health record-keeping in South Africa: Judicial responses, and progress towards a digital remedy
Authors: Kolawole Omowamiwa
Published: September 2024

Numerous South African public health facilities fail to meet their record-keeping obligations as required by law. One of the impacts of this non-compliant medical record-keeping is, as this study found, the undermining of medical negligence claims. The study reviewed numerous South African medical negligence court cases in which an absence of comprehensive, reliable patient records was central to the court’s judgment. The research also examined progress towards, and challenges facing, the South African government’s efforts to improve medical record-keeping through implementation of a national, digital Health Patient Registration System (HPRS) comprising online electronic medical records (EMRs) linked to unique personal identifiers. Based on the study findings, this article concludes with a call for the South African courts to take steps to compel the state, and public health facilities, to meet the record-keeping requirements contained in the country’s applicable legal- regulatory and policy instruments.
The Role Of Zakat In The Digital Era 4.0 For Families In Solving Social Problems Integrated With Technology
Authors: Asman Asman
Published: September 2024

Management in the management of zakat nationally was socialized after the issuance of Law Number 38 of 1999 concerning Zakat Management in Indonesia. However, in the course of the management of zakat management in Indonesia, there are problems in the formation of zakat management at the regional, district, sub-district and zakat managers in the form of community organizations. So that in zakat management the distribution of zakat is not right on target so that zakat management gets pros and cons in the community. The purpose of this study is to examine more deeply the implications of zakat management in Indonesia through the literature so that answers are obtained such as the contribution of solutions in this study. The methodology in this research is the type in this research is a qualitative research literature. While the approach in this study uses a normative juridical approach. The results in this study are the management of zakat management must be adjusted to the needs of those who are entitled to receive it according to the socio-economic conditions of Muslim citizens.Keywords: Role, Zakat, digital era 4.0, family, technology
The Role Of Sharia Economic Law In Supporting A Healthy Economic System For Indonesian Communities
Authors: Hasan Zahid , Nurhuda Abid
Published: September 2024

The dynamics of the development of Sharia economic law in Indonesia have developed rapidly so that in the management of the economy, Sharia and conventional banking have emerged. The lower middle class and informal workers are very vulnerable to being trapped in conventional banks, causing pain in the Indonesian economy. So the purpose of this research is to describe the Role of Sharia Economic Law in Supporting a Healthy Economic System for Indonesian Society. The method used is literature study, then the data is collected using a qualitative approach, then the truth and validity are analyzed and the last is concluded descriptively. The results of the study show that the Role of Sharia Economic Law in Supporting a Healthy Economic System for Indonesian Communities includes making people aware of the importance of paying Zakat, supporting the Prohibition of usury, fostering expectations of economic cooperation, supporting the social security system, supporting the prohibition of business practices which is dirty, and supports the supervision of the sharia economy in the state order so that all of these roles are following the maqosidu sharia which has been established by Islamic teachings.Keywords: Role, Sharia Economic Law, Healthy Economy, Indonesian Society
Regulation Of Sharia Microfinance Institutions Toward Credit Cooperations Based On Sharia Principles
Authors: Martania Mira , Islahudin Ahmad Noor , Kurniati Herlina
Published: September 2024

In empowering the people's economy through providing inclusive and sharia-based financial access. Islamic microfinance institutions, namely credit cooperatives, which aim to provide financial services in accordance with sharia principles to their members. One of the theories underlying the regulation of Islamic microfinance institutions towards credit cooperatives based on Islamic principles is that Islamic finance must follow Islamic principles in every aspect of its operations, including the prohibition of usury, gharar, and maysir, as well as an emphasis on fairness, sustainability, and economic empowerment. The problem of different understanding and interpretation of sharia principles is a challenge in the implementation of this law. In addition, compliance with and supervision of sharia principles is also a problem because it requires deep understanding and effective oversight mechanisms. The purpose of the regulation of Islamic microfinance institutions for credit cooperatives based on sharia principles is to create financial institutions that can provide financial services in accordance with sharia principles to their members. This includes empowering the people's economy, creating a fair and sustainable financial system, and providing more inclusive financial alternatives for the community.Keywords: Economic empowerment, sharia principles, compliance, supervision, regulation
Legal Protection for Financial Technology Services from a Maqashid Syariah Perspective
Authors: Sari Livia Trijunita , Khoiruddin Khoiruddin
Published: September 2024

Fintech currently developing in Indonesia is fintech peer-to-peer lending or what is usually called fintech lending. This fintech company uses data as one of the conditions for becoming a user of this fintech service to carry out transactions on the Fintech application. However, there are no statutory regulations governing information technology-based financial services business activities. The focus of this research problem is how to protect Fintech law in Indonesian legislation and legal protection from the perspective of Maqashid Syariah . The purpose of this research is to find out how fintech legal protection is and to find out fintech legal protection from the Maqashid Syariah Perspective. This research method uses literature study from various literature . The results of this research are that legal protection is provided by OJK Number 77/POJk.01/2016, namely regarding Information Technology-Based Money Lending and Borrowing Services, here in after referred to as POJK LPMUBTI and is contained in the Financial Services Authority Circular Letter Number 2/SEOJK.07/2014. From the perspective of Maqashid Syariah Legal Protection to protect Ad-Din, An-Nafs, An-Nash, Al-Aql, Al-Mal .Keywords: Financial Technology; Supervision; Regulations
Analisis Putusan Nomor 46 PK/Ag/2020 juncto Putusan Nomor 847/Pdt.G/2019/PA.Tng) Terhadap Sengketa Hybrid Contract
Authors: Zahro Ana Latifatuz , Fauzi Moh. Yasir , Pratiwi Nindia
Published: September 2024

Tangerang Religious Court Decision Number 847/Pdt.G/2019/PA.Tng which has legal force is still requested for judicial review. So that the Supreme Court of the Republic of Indonesia in Decision Number 46 PK/Ag/2020 canceled decision Number 847/Pdt.G/2019/PA.Tng and re-adjudicated with the ruling of refusal. There are differences of opinion in legal considerations between Judex Facti Decision Number 847/Pdt.G/2019/PA.Tng and Judex Juris Decision Number 46 PK/Ag/2020. The qualitative research method uses a type of library research with descriptive analytical research. The results of the discussion show that Judex Facti granted the tort claim with his legal consideration that the elements of tort were proven. While Judex Juris the elements of tort are not proven. Legal interpretation as the core of legal hermeneutics aims as an intermediary in the context of legal discovery by judges in court. The method of legal hermeneutics with interpretation, namely conducting an examination of the texts of sharia economic dispute documents. In order to avoid differences of opinion in terms of sharia economic disputes, especially tort or default, it is necessary to make a circular letter of the supreme court. In sharia transactions, the parties before signing the contract should be read and researched to understand the contents of the contract.Keywords: Hermeneutics; Sharia Economic Dispute; Hybrid Contract
Fintech And Financial Innovation: Online Transportation Services In The Perspective Of Shari'ah Economic Law
Authors: Kulsum Sayyidah Sekar Dewi , Aprilianti Aprilianti
Published: September 2024

Fintech are constantly undergoing updates along with the times, one of which is the Online Transportation business, which is an internet application-based public transportation service that can be used instantly via a smartphone application. The novelty of the mechanism and the convenience offered in this service of course also give rise to various new problems that may occur in the engagement. Therefore, the following problem formulation is presented: 1. How is the online transportation service engagement at PT Ujung Drajad, and 2. What is the Sharia Economic Law analysis of this engagement. This research aims to find out as clear an answer as possible regarding the formulation of the problem under study. The research method used is field research. Data processing was carried out using qualitative methods with an inductive thinking approach. From the findings of this research, there are inconsistencies between the Agreement and its implementation. There is different treatment from the company (PT Ujung Drajat) towards Titip Bendera drivers between those with family status and those without. For those who are family, they are charged 7% of their weekly income, while for drivers who are not family, they are charged 10%. There is a reduction in car rental prices for drivers who have a lot of rental arrears, namely from 200,000 per day to 150,000 per day. Based on the analysis of Islamic law, on the one hand, the agreement has fulfilled the pillars, conditions and principles of the agreement. On the other hand, there are those who violate the principles of justice and the principles of equity and equality in the principles of Islamic relations. However, in general, this agreement is legally permissible. According to its form, this agreement is an ordinary agreement (contract) in the form of cooperation (syirkah) and lease (ijaroh).Keywords: Partnership; Online Transportation; Islamic Law;
Techniques from Language Practices of Highly Cited Authors for Technical and Vocational Education and Training Research Writing
Authors: Suryani Ina , Yaacob Aizan , Mohd Asraf Ratnawati , Supian Nadya , MdHussin Haniza , Yousef Alsaraireh Mohammad
Published: September 2024

Technical and Vocational Education and Training has gained importance but there is a noticeable gap between its research and teaching. While its teaching is more dynamic the research writing is scarce despite the performance measure demands. Rapid technological advancements, the multifaceted roles of the teachers, and the second language barrier escalate the pressure on research performance measures. Language models for research writing can help to alleviate research writing language practices. This paper explores the language practices of highly cited research articles for the technical and vocational education and training application. Specifically, it looks at how prolific writers write. Given the pressing need for a more accessible and more descriptive language model for technical and vocational research writing, this paper aims to assist by presenting techniques derived from the analysis of 62 highly cited research articles indexed in Scopus. Using move analysis, the study identifies 14 emerging techniques used in the introduction sections, offering a model for the writers and instructors. The techniques highlighted in this study not only enhance the engagement of introductions but also aim to increase readership and citation rates.
Foregrounding Aspects in Dylan Thomas’ Before I Knocked: A Stylistic Analysis
Authors: Sabah Ahmad Rawand , Sabah Meena Reman , Shamsadin Muhammed Dana
Published: September 2024

Vivid imagery and intricate tapestry of linguistic features are essential to grasp literary significance and appreciation in Dylan Thomas’ poems. This study focuses on one of his most significant poems, Before I Knocked for an in-depth investigation. The study is significant in because combining both the theory of foregrounding and the checklist is unique in this type of study. Therefore, the study aims to analyze Thomas’ selected poem and demonstrate how and why various linguistic elements are systematically utilized to create value and quality in the poem. Concerning this, the study utilises qualitative descriptive analysis relying on stylistic analysis within which the theory of foregrounding supplemented by Leech and Short’s checklist, is applied. Ultimately, the study finds that Thomas has employed linguistic features and foregrounding aspects systematically and coherently to carry meaning and theme and relate the form and the content of his work. The study also recommends integrating linguistic features in literary stylistic analysis is essential for learners and pedagogical purposes.
Pengujian In Vitro Serum Antiacne Kombinasi Ekstrak Daun Kemangi dan Rimpang Kunyit
Authors: Fitri Cahyani Mayassa , Halimatushadyah Ernie , Krismayadi
Published: September 2024

Abstract—Acne is a chronic inflammation of the pilosebaceous follicles which is characterized by excess oil production caused by the bacterium Propionibacterium acnes. The content of flavonoids in basil leaves and the content of curcumin in turmeric rhizome can be used as an anti-acne treatment. The purpose of this study was to determine the anti-acne activity of a single extract of basil leaves and a single extract of turmeric rhizome, to determine the ability of the combination two extracts to inhibit acne-causing bacteria and to formulate combination of basil leaf extract and turmeric rhizome into a serum preparation to determine antibacterial activity against Propionibacterium acnes. The research method used was experimental by testing the antibacterial activity of Propionibacterium acnes in vitro. Antibacterial activity test results in serum showed a negative control, namely serum base did not have an inhibition zone, positive control clindamycin phosphate showed an inhibition zone of 13.20 mm, with a ratio between extracts of turmeric rhizome and basil leaves 1:4, the diameter of the inhibition zone was obtained at a concentration of 30 % of 5.7 mm, 40% concentration of 7.38 mm and 50% concentration of 8.11 mm. Statistical analysis was carried out using the Shapiro-Wilk, Levene Statistics, and One Way Anova methods (p<0.05).
Keywords: acne, basil, p. acnes, serum, turmeric
 
Abstrak—Jerawat merupakan peradangan kronik folikel pilosebasea yang ditandai dengan adanya produksi minyak berlebih yang disebabkan oleh bakteri Propionibacterium acnes. Kandungan flavonoid pada daun kemangi dan kandungan kurkumin pada rimpang kunyit dapat dimanfaatkan sebagai pengobatan antijerawat. Sediaan farmasi yang dapat digunakan untuk mengatasi masalah kulit berjerawat yaitu serum. Tujuan penelitian ini adalah mengetahui aktivitas antijerawat pada ekstrak tunggal daun kemangi dan ekstrak tunggal rimpang kunyit, mengetahui kemampuan kombinasi kedua ekstrak dalam menghambat bakteri penyebab jerawat dan memformulasikan kombinasi ekstrak daun kemangi dan rimpang kunyit menjadi sediaan serum untuk mengetahui aktivitas antibakteri terhadap Propionibacterium acnes. Metode penelitian yang digunakan adalah eksperimental dengan melakukan uji aktivitas antibakteri Propionibacterium acnes secara in vitro. Hasil uji aktivitas antibakteri pada serum menunjukkan kontrol negatif yaitu basis serum tidak mempunyai zona hambat, kontrol positif clindamycin phospat menunjukkan zona hambat sebesar 13,20 mm, dengan perbandingan antara ekstrak rimpang kunyit dan daun kemangi 1:4 diperoleh hasil diameter zona hambat pada konsentrasi 30% sebesar 5,7 mm, konsentrasi 40% sebesar 7,38 mm dan konsentrasi 50% sebesar 8,11 mm. Analisa statistik dilakukan dengan metode Shapiro-wilk, Levene statistic, dan One Way Anova (p<0,05).
Kata kunci: jerawat, kemangi, kunyit, p. acnes, serum
El esquema de clases sociales en Bolivia. Libro de Eduardo Paz Gonzales
Authors: Zapata Francisco
Published: September 2024

El libro de Eduardo Paz Gonzalez, Esquema de clases sociales en Bolivia, publicado en La Paz, en 2023, contribuye al análisis y comprensión de las transformaciones que experimentó la estructura social de Bolivia tal como se puede inferir de la Encuesta Nacional de Hogares (ENH). Hasta cierto punto, es heredero de lo que fue el estudio de la estratificación social que enfocaron Lipset, Germani, Di Tella. El foco de la investigación de Eduardo Paz tiene como telón de fondo el caso boliviano que, en las dos primeras décadas del siglo XXI, experimentó profundos cambios. El análisis plantea ejes temáticos que contribuyen a ordenar la presentación de los datos que se derivan de la Encuesta de la ENH: los grupos ocupacionales, la situación de empleo, los niveles educativos, la evolución de los ingresos y las características del trabajo (permanente o precario).
Ranking szkół wyższych jako predyktor zatrudnialności
Authors: Rocki Andrzej
Published: September 2024

Corocznie ukazujące się rankingi uczelni wyższych porządkują w pewnym sensie informacje o systemie szkolnictwa wyższego, ale tworzone są z myślą o bieżących analizach, a w tym do podejmowaniu decyzji przez kandydatów na studia. Współistnienie ogólnopolskiego systemu monitorowania ekonomicznych losów absolwentów skłania do zestawienia wyników wybranego rankingu z losami absolwentów. W artykule wykorzystano dane o wynikach rankingu w podziale na uczelnie publiczne i niepubliczne oraz dane ze wspomnianego systemu monitorowania. Celem prac było sprawdzenie, czy wybranie przez kandydatów na studia uczelni zajmujących czołowe miejsca w rankingu daje podstawy do przewidywania lepszej – niż w przypadku wyboru innej uczelni – sytuacji na rynku pracy w pięć lat po uzyskaniu dyplomu. Wskazano, że w przypadku uczelni publicznych ranking jest dobrym predyktorem w tym zakresie. W przypadku uczelni niepublicznych analizy nie wskazały na istotnie lepszą sytuację absolwentów czołówki rankingu od absolwentów pozostałych uczelni.
Choroba afektywna dwubiegunowa i leczenie litem: narracja osobista w kontekście niektórych rocznic
Authors: Rybakowski Janusz
Published: September 2024

Omówiono rocznice i postacie z nimi związane dotyczące choroby afektywnejdwubiegunowej (maniakalno-depresyjnej) i leczenia litem. Rok 1854 (170. rocznica): koncepcja choroby maniakalno-depresyjnej: Jules Ballairger (folie double forme); Jean-Pierre Falret (folie circulaire); Rok 1859 (165. rocznica): zastosowanie litu w leczeniu dny reumatycznej – Alfred Barrod; Rok 1899 (125. rocznica): dychotomiczna koncepcja zaburzeń psychicznych – Emil Kraepelin (manisch-depressives Irresein, dementia praecox); Rok 1929 (95. rocznica): wprowadzenie napoju „7-up” zawierającego lit; Rok 1934 (90. rocznica): koncepcja zaburzeń dwubiegunowych – Karl Kleist (zweipolig ); Rok 1949 (75. rocznica): wprowadzenie litu do współczesnej psychiatrii – John Cade; Rok 1954 (70. rocznica): wykazanie przeciwmaniakalnego działania litu metodą z placebo – Mogens Schou; Rok 1974 (50. rocznica): koncepcja rapid cycling (David Dunner i Ronald Fieve); Rok 1984 (40. rocznica): koncepcja choroby afektywnej sezonowej – Norman Rosenthal; Rok 1989 (35. rocznica): koncepcja mechanizmu działania litu – Michael Berridge (układ fosfatydyloinozytolu); Rok 1999 (25. rocznica): powstanie International Society of Bipolar Disorders – David Kupfer i Ellen Frank; rozpoczęcie wydawania pisma: Bipolar Disorders – Samuel Gershon i Jair Soares; koncepcja excellent lithium responders – Paul Grof; Rok 2009 (15. rocznica): powstanie ConLiGen (International Consortium of Lithium Genetics); wykazanie ujemnej zależności między stężeniem litu w wodzie pitnej a samobójstwami; Rok 2019 (5. rocznica): książka: Lit – niezwykły lek w psychiatrii.
O nowy model poznawczy humanistyki – poznańska szkoła metodologiczna (część I)
Authors: Grad Jerzy
Published: September 2024

Poznańska szkoła metodologiczna to formacja badawcza funkcjonująca na Uniwersytecie im. A. Mickiewicza w Poznaniu, od połowy lat 60. XX wieku do 1973 roku, której twórcami byli J. Kmita, L. Nowak i J. Topolski. Opracowała ona oryginalny naturalistyczny i antypozytywistyczny metodologiczny model humanistyki, który zakładając metodologiczną jedność nauk humanistycznych i przyrodniczych, określa równocześnie metodologiczną specyfikę nauk humanistycznych. Wynika ona ze stosowania w praktyce badawczej humanistów dedukcyjnego wyjaśniania naukowego nazwanego interpretacją humanistyczną. W latach 1970–1973 uprawiano metodologię marksistowską. Odkryto, że oryginalną Marksowską metodą badawczą jest procedura idealizacji i konkretyzacji. Po tym okresie nastąpił rozpad poznańskiej szkoły metodologicznej jako grupy badawczej przyjmującej wspólne założenia teoretyczne. Oryginalność i nowatorski charakter jej analiz i ustaleń naukoznawczych zyskał jej znaczny rozgłos w świecie nauki i stał się przedmiotem ożywionych debat, dyskusji, polemik i ostrych sporów, czego dzisiaj historycznym świadectwem są opublikowane recenzje.
Feed additives supplementation: a potential strategy to ameliorate heat stress in sheep
Authors: Binuni Rebez E. , Sejian V. , Silpa M.V. , Kalaignazhal G. , Devaraj C. , Nikhil K.T. , Ninan J. , Tüfekci H. , Fonsêca V. F. C. , Chauhan S. S. , DiGiacomo K. , Dunshea F.R. , Lacetera N.
Published: September 2024

Given a significant climate-flexible and socio-economic role in developing nations, environmental heat stress imposes a major financial impact on sheep production systems globally endangering their production, reproduction, and growth. In this regard, the adverse effects of heat stress on sheep production systems have to be addressed through adoption of effective heat alleviation measures like animal management, nutritional management and genetic interventions of which the nutritional interventions seems to be the most cost effective way to alleviate heat stress. Nutritional manipulation for heat stress alleviation in sheep involves the use of antioxidant supplements (Vitamin B; Vitamin E and Selenium; Selenium; Zinc sulphate and folic acid; Vitamin C, Vitamin E, Selenium and Zinc; Naringin; Opuntia ficus-indica f. inermis; Açai oil and Brown seaweed like Ascophyllum nodosum and Sargassum latifolium). Further, electrolyte supplements (Dietary Electrolyte Balance (DEB); Sodium bicarbonate and potassium bicarbonate; Sodium hydroxide) have a beneficial effect on thermal responses, respiratory activities, gas exchange parameters, rumen fermentation, blood buffering capacity and acid-base balance. The mineral mixture supplements (Mineral blocks; Mineral mixture and antioxidants; Chromium; Zinc) play a crucial role in increasing the efficiency of antioxidant defence system, immunity-related parameters, production, reproduction, feed digestibility and insulin sensitivity. Probiotic supplements (Lactobacillus acidophilus, Saccharomyces cervisiae, Propionibacterium freudenreichii, Lactobacillus casei, Enterococcus faecium, Lactobacillus lactis, Bacillus subtilis, Propionibacterium freudenreichii, Pediococcus cerevisiae, Megaspha eraelsdenii, Bacillus licheniformis, Aspergillus oryzae, Schizochytrium limacinum, Trichoderma reesei and Saccharomyces cerevisiae) improve lactational performance, dietary energy utilization and productivity. The probiotics (live Saccharomyces cerevisiae) and prebiotics (mannan oligosaccharide plus b-glucans) used in heat stress alleviation improve dietary energy utilisation. Furthermore, the vital role of herbal supplements (Rosemary, Cinnamon, Turmeric, Clove, Naringin, Chestnut tannins, Giloy stem powder, Curcumin, Rocket oil (watercress oil), Flaxseed, Cornus, Oregano, Thyme, Chamomile flowers, Moringa oleifera, Betaine) has been highlighted to promote feed intake, antioxidant status, growth performance, feed utilization, reproductive performance and immune response. Effective adoption of nutritional strategies can thus ensure sustainable sheep production in this changing climate scenario.
Patient needs, functional requirements, aesthetic preferences and barriers in app-based therapy for knee osteoarthritis
Authors: Erjavec Karmen , Kotnik Petra
Published: September 2024

Introduction. Knee osteoarthritis (KOA) is an infl ammatory condition aff ecting over 25% of adults. Web/mobile technology off ers potential benefi ts in the treatment of KOA by improving access to care and reducing costs by utilising mobile devices for medical care and patient education.

Aim. The study aims to answer the question of what needs, functional requirements and aesthetic preferences patients with knee osteoarthritis have and what barriers and facilitators there are when using an app-based therapy.

Material and methods. We used a qualitative research design with in-depth interviews with 20 patients.

Results and conclusion. Interviewees emphasized that effective KOA management apps must address diverse patient needs, ensure accessibility, offer customizable features, provide comprehensive information and self-management tools, support pain relief, enable remote monitoring, integrate with support communities, and be cost-efficient. These apps should combine functional requirements, such as a simple user interface, integration with wearable devices, educational content, exercise guidance, pain management tools, remote consultations, community support, and feedback mechanisms, with aesthetic preferences for clear, accessible design, large fonts, high-contrast colours, suitable interactive elements, consistent layout, guiding animations, and accessibility features like text resizing, voice commands, and audio descriptions. In conclusion, this study underscores the necessity for KOA management apps to integrate diverse functional requirements and aesthetic preferences, ensuring accessibility, customization, comprehensive information, and support features to enhance usability, effectiveness, and patient satisfaction.
A Modal Analysis of the Cantonese Particle Gamzai
Authors: Lee Margaret Chui Yi , Hsiao Katherine Pei-Yi , Lin Jonah Tzong-Hong
Published: September 2024

This paper offers a novel analysis to account for the semantics of the adverbial approximator gam3zai6. New data are presented, illustrating that gam3zai6 should be distinguished from its apparent scalar counterparts such as almost in English and chabuduo ‘almost’ in Mandarin Chinese. Building upon Portner’s (1998) analysis of the progressive in English, we propose a modal analysis of gam3zai6 as a prospective operator which creates an intensional context for the expressed event/state under the scope of prospectivity. We incorporate the temporal indication into the semantics of gam3zai6, enabling a unified account for the diverse interpretations of gam3zai6-sentences.
“A drink for the Soul”: the Coffee tree and Coffee as a Symbol of the Arab National Mentality
Authors: Kukhareva E. V.
Published: September 2024

In the complex geopolitical situation of the beginning of the twenty-first century and with the change of the vector of interests towards the countries of the East, attention to all aspects of the life of the peoples of these states is increasing due to the urgent need to understand their cultures, lifestyle, and the world around them. These peoples are increasingly active in the international arena, their role in various fields is becoming more noticeable, and it is important to interact with them at various levels. To do this, it is necessary to know what this people live by, what their priorities are, what is important or secondary for them. The complexity of intercultural communication lies in the fact that the national character and mentality of representatives of different linguistic cultures is based on the existing realities of a particular people’s life, its moral values and attitudes, through which various ethnic communities identify themselves and fix their place and purpose in this world. Symbols and images reflecting these ideas take either a material or verbal shell and convey an ethnic picture of the world of a particular people, which is completely different from the ideas of other ethnic groups about what surrounds them. To understand a representative of another linguistic consciousness, it may not be enough to master the vocabulary and grammar of a foreign language. Significant elements of the language in their semantic part also contain an extra-linguistic component, so-called “background knowledge”, which can be gleaned from the history, mythology, literature, and folklore of the people with whom we are interacting. This extra-linguistic component, according to the author, is of great importance for understanding national mentality and national character. It helps to identify other driving forces of the actions of different peoples in the process of intercultural communication, along with their political and economic interests. In this article, the author considers one of the symbols of the national mentality of the Arabs – the coffee tree and its derivative – the coffee drink, which plays an important role in creating a national collective portrait of Arab society. She also attempts to show how and why they occupy such an important place in the Arab national consciousness.
Positive Blood Culture Profile Through Systematic Review
Authors: Lemos Mauro Victor Castro , Zafred Ivana Fiquene , Silva Luís Cláudio Nascimento da , Aliança Amanda Silva dos Santos , Firmo Wellyson da Cunha Araújo , Nunes Márcio Anderson Sousa
Published: September 2024

Objective: This study aimed to gather data on the prevalence of microorganisms in the bloodstream. 
 
Theoretical Framework: In this topic, the fundamental theoretical bases for research on Bloodstream Infections (BSI) are presented. Epidemiological, microbiological and clinical aspects stand out, including incidence, microorganisms involved, antimicrobial resistance and clinical and economic impacts. Furthermore, the importance of systematic reviews in the synthesis and critical evaluation of available evidence is discussed. 
 
Method: This study was carried out based on a systematic bibliographic review, where data from articles published in scientific journals in the Google Scholar, Lilacs and PubMed databases were collected and selected, from 2012 to 2019. 
 
Results and Discussion: In the various articles analyzed in this review, 52 different microorganisms were found. Staphylococcus aureus and Klebsiella pneumoniae are the most prevalent in the group of microorganisms observed in positive blood cultures. Regarding gender, it was found that of the 2,210 samples corresponding to the total number of positive blood cultures in the 21 articles analyzed, 36% were positive for males and 64% for females. 
 
Research Implications: Highlights the importance of surveillance and effective control of Bloodstream Infections, especially considering the prevalence of microorganisms such as Staphylococcus aureus and Klebsiella pneumoniae, influencing health practices, public policies and hospital protocols. 
 
Originality/Value: This study contributes to the literature by gathering data on the prevalence of microorganisms in Bloodstream Infections, providing essential insights to improve prevention and control practices, directly impacting public health and patient safety.
Book Review of Home Truths aims to shake up the Canadian housing system
Authors: Thomas Ren
Published: September 2024

A review of Carolyn Whitzman's Home Truths.
Whitzman, Carolyn. 2024. Home Truths. Vancouver, BC: University of British Columbia Press. 288 pages. $29.95 (paperback). ISBN: 9780774890700
“Cui Bono?” An Agricultural Turning Point in the Roman Provinces Upper Germania and Raetia
Authors:   Institut für Ur- und Frühgeschichte und Vorderasiatische Archäologie, Universität Heidelberg, Sandgasse 7, 69117 Heidelberg, Germany, Rösch Manfred ,   Laboratory for Archaeobotany, Baden-Württemberg State Office for Cultural Heritage, Fischersteig 9, 78343 Gaienhofen-Hemmenhofen, Germany, Marinova Elena ,   Laboratory for Archaeobotany, Baden-Württemberg State Office for Cultural Heritage, Fischersteig 9, 78343 Gaienhofen-Hemmenhofen, Germany, Zach Barbara ,   Archäobotanik Labor Zach, Weidachring 4, 86975 Bernbeuren, Germany
Published: September 2024

The history of agricultural innovation, intensification and the associated diversity of land use and plant food consumption in the Roman provinces of Upper Germania and Raetia was investigated using charred plant macrofossils (on-site data) and pollen assemblages (off-site data). A presence/absence data set compiled from major published data (n=106) allowed to assess the diversity of food plants according to site types. Highest diversity occurred at small vici (rural villages), reflecting the diversity of features studied, but also the diversity of activities typical for this site type. Generally, the larger, urbanised or military sites, such as forts and large vici (country towns), show higher plant food diversity compared to the smaller, rural sites such as villae rusticae. This difference is based mainly on the diversity of fruits, vegetables and spices consumed. To put the results in a broader chronological context, the feature-based ubiquity of charred finds of six taxa, as indicators of less intensive agriculture (i.e. lowintensity tillage, longer fallow period, smaller field sizes) were evaluated. This dataset obtained from 248 archaeological sites covering the period from Bronze Age to Middle Ages, showed the strongest decrease of perennial arable weeds during the Roman period pointing to a possible shortening of fallow periods and deeper tillage than before. The pollen records (n=7) indicate a decreasing importance of wood pasture and ruderals during the Roman period compared to the preceding and following periods. The studied archaeobotanical evidence indicates a clear turning point in food culture and land use in the area during the Roman period.