bluuebunny/crossref_metadata_2025 huggingface dataset:
The Missing Link in Resident Support for Tourism Events: The Role of Tolerance
Authors: Qi Rui , So Kevin Kam Fung , Cárdenas David A. , Hudson Simon
Published: July 2021

Social exchange theory, the key theoretical framework in examining resident support, has often been criticized as ambiguous and difficult to measure. Extensive research has investigated the nature of resident support for tourism events, yet the role of a key construct, tolerance, has been underexplored. Building on the extant literature, this study conceptualizes and tests the theoretical construct of tolerance as a missing link to better understand, measure, and clarify the exchange process. The results suggest that resident tolerance partially mediates the effects of perceived benefits on resident support for events while fully mediating the effects of perceived costs on such support. In addition, resident empowerment is a critical factor explaining tolerance. This study contributes to the literature by identifying the major source of the unbalanced impacts of benefits and costs on support reported in previous studies. Findings also offer a more complete picture on how residents translate the perceived impacts of tourism events into support through tolerance.
Multidisciplinary cooperative mode led by infusion nurse specialists used to ensure the nursing quality of peripherally inserted central catheters in China: A 5-year retrospective study
Authors: Jie Cao , Chunxue Peng , Jiawei Xu , Hongmei Li , Huohong Qian
Published: July 2021

Objective:

To analyze the effect of multidisciplinary cooperation mode (MCM) led by infusion nurse specialists (INSs) on peripherally inserted central catheters (PICC) catheterization and indwelling nursing quality.

Methods:

Participants’ demographic information, catheter types, catheterization approaches, puncture site, tip position, professional title of nurses, success rate of catheterization, consultation rate, detection rate of complications and outcome improvement rate of 6576 outpatients and hospitalized patients with PICC were analyzed retrospectively by a software named “questionnaire stars,” in a large tertiary general hospital in Shanghai, from January 2015 to December 2019. SPSS 26.0 for Windows was used for data collection and description, Chi-square test were used for statistical analysis of enumeration data, and p < 0.05 was statistically significant.

Results:

According to the catheter types’ data, the use rate of three-way valve catheters decreased from 79.9% to 14.5%, while the use rate of three-way valve solo catheters increased from 12.7% to 51.6%, and the use rate of power injectable and open-ended catheters increased from 7.4% to 33.9%. According to the data of PICC catheterization method, conventional technology decreased significantly from 16.8% to 1.1%, modified Seldinger technique (MST) increased gradually from 26.1% to 51.3%, while ultrasound guided modified Seldinger technique (US and MST) decreased slightly from 57.2% to 47.6%. 7.5% catheter tip ends were malpositioned while nine indwelled PICCs were traced to have tip end malposition. The consultation rate was significantly higher than that before applying MCM led by INSs ( x2 = 151.713, p < 0.05). After applying MCM led by INSs, the detection rate of complications was significantly higher than before ( x2 = 5.499, p < 0.05), the rate of successful insertion at one time was significantly higher than before ( x2 = 187.589, p < 0.05).

Conclusion:

After the application of INSs-led MCM, progresses have been achieved. The nursing quality of patients’ PICC was significantly improved than before.
Contrast enhanced ultrasound as a new tool to estimate the performance of midline catheters in the single patient
Authors: Gidaro Antonio , Casella Francesco , Lugli Francesca , Cogliati Chiara , Calloni Maria , Samartin Federica , Brena Nicola , Pace Guido
Published: July 2021

Background:

Contrast enhanced ultrasound (CEUS) through MicroBubbles Time (MBT) (time from infusion of saline with addition of micro-bubbles of air to visualization of first bubbles in right atrium (RA), visualized by subxiphoid or apical echocardiography) is an alternative to Intracavitary ECG and chest X-ray in evaluation of tip location in central venous catheters.

Objective:

To evaluate feasibility and variability of CEUS in peripheral catheters (Midline-MC) in a cohort of patients and in a subgroup where tip location was also performed through chest X-ray. Secondary outcomes were verifying the correlation between MBT and distance between tip of MC and RA (anthropometric and radiological measures), body mass index (BMI), vein diameter at point of insertion.

Methods:

Patients with insertion of MC were enrolled in this prospective cohort. After catheter insertion, CEUS was performed recording MBT.

Results:

One hundred thirty-two MCs were inserted, 45 performed Chest X-ray. MBT wasn’t feasible in 7 (5%) because of low quality echocardiographic images. Subcostal view was available in 114 patients (91.2%), while 11 patients (8.8%) were examined through apical four-chamber view. Mean MBT in the whole population was 2.3 ± 0.8 s. Significant correlation between anthropometric and radiological measures, BMI and MBT was found. 32.8% of MC had a MBT ⩽2 s.

Conclusions:

CEUS could be useful to estimate tip position. Our study showed how 2 s is not a suitable cutoff to confirm central catheter’s tip.
Current role of ultrasound in hemodialysis access evaluation
Authors: Mario Meola , Ibeas Jose , Malik Jan
Published: July 2021

Physical examination (PE) is considered the backbone before vascular access (VA) placement, during maturation period and for follow-up. However, it may be inadequate in identifying suitable vasculature, mainly in comorbid patients, or in detecting complications. This review highlights the advantages of ultrasound imaging to manage VA before placement, during maturation and follow-up. Furthermore, it analyses the future perspectives in evaluating early and late VA complications thank to the availability of multiparametric platforms, point of care of ultrasound, and portable/wireless systems. Technical improvements and low-cost systems should favor the widespread ultrasound-based VA surveillance programs. This significant turning point needs an adequate training of nephrologists and dialysis nurses and the standardization of exams, parameters, and procedures.
Advancing book clubs as non-formal learning to facilitate critical public pedagogy in organizations
Authors: Grenier Robin S , Callahan Jamie L , Kaeppel Kristi , Elliott Carole
Published: July 2021

Book clubs are a well-known form of social engagement and are beneficial for those who take part, yet book clubs are not fully realized within management as a site for learning. This is unfortunate because book clubs that read fiction can foster social processes and help employees in search of more critical and emancipatory forms of learning. We theoretically synthesize the literature to advance current thinking with regard to book clubs as critical public pedagogy in organizations. We begin by introducing book clubs as non-formal adult learning. Then, book clubs that employ fiction as a cultural artifact are presented as a way for members to build relationships, learn together, and to engage in cultural change work. Next, the traditional notions of book clubs are made pedagogically complex through the lens of critical public pedagogy. Finally, we offer two implications: (1) as public pedagogy, book clubs can act as an alternative to traditional learning structures in organizations; and (2) book clubs, when valued as public pedagogy, can be fostered by those in management learning and HRD for consciousness raising and challenging existing mental models in their organizations.
Deepfaking Keanu: YouTube deepfakes, platform visual effects, and the complexity of reception
Authors: Bode Lisa
Published: July 2021

On July 14, 2019, a 3-minute 36-second video titled “Keanu Reeves Stops A ROBBERY!” was released on YouTube visual effects (VFX) channel, Corridor. The video’s click-bait title ensured it was quickly shared by users across platforms such as Facebook, Twitter, and Reddit. Comments on the video suggest that the vast majority of viewers categorised it as fiction. What seemed less universally recognised, though, was that the performer in the clip was not Keanu Reeves himself. It was voice actor and stuntman Reuben Langdon, and his face was digitally replaced with that of Reeves, through the use of an AI generated deepfake, an open access application, Faceswap, and compositing in Adobe After Effects. This article uses Corridor’s deepfake Keanu video (hereafter shorted to CDFK) as a case study which allows the fleshing out of an, as yet, under-researched area of deepfakes: the role of framing contexts in shaping how viewers evaluate, categorise, make sense of and discuss these images. This research draws on visual effects scholarship, celebrity studies, cognitive film studies, social media theory, digital rhetoric, and discourse analysis. It is intended to serve as a starting point of a larger study that will eventually map types of online manipulated media creation on a continuum from the professional to the vernacular, across different platforms, and attending to their aesthetic, ethical, cultural and reception dimensions. The focus on context (platform, creator channel, and comments) also reveals the emergence of an industrial and aesthetic category of visual effects, which I call here “platform VFX,” a key term that provides us with more nuanced frames for illuminating and analysing a range of manipulated media practices as VFX software becomes ever more accessible and lends itself to more vernacular uses, such as we see with various face swap apps.
Telestroke for acute ischaemic stroke: A systematic review of economic evaluations and a de novo cost–utility analysis for a middle income country
Authors: Tan Elise , Gao Lan , Tran Huong NQ , Cadilhac Dominique , Bladin Chris , Moodie Marj
Published: July 2021

Introduction

Telemedicine can alleviate the problems faced in rural settings in providing access to specialist stroke care. The evidence of the cost-effectiveness of this model of care outside high-income countries is limited. This study aimed to conduct: (a) a systematic review of economic evaluations of telestroke and (b) a cost–utility analysis of telestroke, using China as a case study.

Methods

We systematically searched Embase, Medline Complete and Cochrane databases. Inclusion criteria: full economic evaluations of telemedicine/telestroke networks examining the use of thrombolysis in patients with acute ischaemic stroke, published in English. A cost–utility analysis was undertaken using a Markov model incorporating a decision tree to simulate the delivery of telestroke for acute ischaemic stroke in rural China, compared to no telestroke from a societal and healthcare perspective. One-way deterministic sensitivity analyses and probabilistic sensitivity analyses were performed to test the robustness of results.

Results

Of 559 publications found, eight met the eligibility criteria and were included in the systematic review (two cost-effectiveness analyses and six cost–utility analyses, all performed in high-income countries). Telestroke was a cost-saving/cost-effective intervention in five out of the eight studies. In our modelled analysis for rural China, telestroke was the dominant strategy, with estimated cost savings of Chinese yuan 4,328 (US$627) and additional 0.0925 quality-adjusted life years per patient. Sensitivity analyses confirmed the base case results.

Discussion

Consistent with published economic evaluations of telestroke in other jurisdictions, telestroke represents a cost-effective solution to enhance stroke care in rural China.
Talking about chronic pain: Misalignment in discussions of the body, mind and social aspects in pain clinic consultations
Authors: Declercq Jana
Published: July 2021

In Western societies, human existence and illness are mostly constructed from the perspective of mind-body dualism: body and mind are considered to function independently, and the body/the physical as primary and more real. Research shows, however, that mind-body dualism is no longer tenable, especially in healthcare contexts. This led to the rise the biopsychosocial model, in which bodily experiences, including illness, are seen an interplay of the physical and the psychological, and the social. This model is the current gold standard for treating chronic pain. As these perspectives on the body and illness are potentially conflicting, and discursively constructed, this paper examines whether they are a source of misalignment in interactions between chronic pain patients and their doctors in a pain clinic. The analysis shows these perspectives indeed lead to misalignment, for instance when discussing the relevance of psychotherapy, and lead to intricate uses of argumentative resources to account for the differing perspectives on (the treatment of) pain.
Real-world data-based adverse drug reactions detection from the Korea Adverse Event Reporting System databases with electronic health records-based detection algorithm
Authors: Shin Hyunah , Cha Jaehun , Lee Youngho , Kim Jong-Yeup , Lee Suehyun
Published: July 2021

Pharmacovigilance involves monitoring of drugs and their adverse drug reactions (ADRs) and is essential for their safety post-marketing. Because of the different types and structures of medical databases, several previous surveillance studies have analyzed only one database. In the present study, we extracted potential drug–ADR pairs from electronic health record (EHR) data using the MetaNurse algorithm and analyzed them using the Korean Adverse Event Reporting System (KAERS) database for systematic validation. The Medical Dictionary for Regulatory Activities (MedDRA) and World Health Organization (WHO) Adverse Reactions Terminology (WHO-ART) were mapped for signal detection. We used the Side Effect Resource (SIDER) database to select 2663 drug-ADR pairs to investigate unknown drug-induced ADRs. The reporting odds ratio (ROR) value was calculated for the drug-exposed and non-exposed groups of drug–ADR pairs, and 19 potential pairs showed significant signals. Appropriate terminology systems and criteria are needed to handle diverse medical databases.
Independent or a political pawn? How recipients perceive influences on journalistic work compared to journalists and what explains their perceptions
Authors: Obermaier Magdalena , Steindl Nina , Fawzi Nayla
Published: July 2021

Journalistic autonomy is a prerequisite for the public function of journalism. Although most journalists in Western democracies indicate particularly low political or economic influences on their work, there is evidence that recipients assume that journalism is driven primarily by political and economic interests. These perceptual discrepancies can be problematic as perceived influences on journalistic work are known to reduce recipients’ media trust. Hence, this study addresses the extent to which recipients perceive influences on journalistic work, how their perceptions differ from that of journalists, and which variables explain recipients’ perceptions. A representative online survey of German recipients ( n = 1000) and the representative sample of German journalists of the Worlds of Journalism Study ( n = 775) demonstrate that recipients perceive stronger influences on journalistic work than journalists do, especially in regard to politics and economics. Furthermore, recipients who display higher levels of anti-elitism, selective exposure and media literacy assume stronger influences on journalistic work.
Out of the blue and into it: Autoethnography, emotions and complicated grief
Authors: Akehurst Georgie , Scott Susie
Published: July 2021

Autoethnography can be an appropriate method for researching complex emotional experiences. However, the highly self-reflexive processes involved in mining personal data are subject to a set of cultural feeling and display rules, which obscure and interfere with emotional engagement. To illustrate this, we present one author’s account of using autoethnography to research traumatic bereavement. We critically revisit three myths about the method: one negative (autoethnography is narcissistically self-indulgent) and two positive (autoethnographic techniques are therapeutic and autoethnographic writing is authentic). Observing some parallels between topic and method, we suggest that both are complicated and non-linear, following convoluted paths. Autoethnographic tales may defy the social rules of verbal tellability, failing to reveal personal insights or offer moral lessons. We conclude that, while we can admire the autoethnographic endeavour towards ‘heartfelt’ scholarship, this should be tempered by a cautiousness about the costs of digging deep.
Questioning the feasibility and justice of basic income accounting for migration
Authors: Löffler Verena
Published: July 2021

When studying the feasibility and justice of basic income, researchers usually assume that policymakers would be introducing the unconditional benefit to a closed economic entity. When contemplating the introduction of a universal policy, few researchers take into consideration the fact that citizens and foreigners migrate, and that this movement alters the size and skill structure of the population. This article addresses this oversight by analyzing how basic income schemes based on residence or citizenship may affect tax base, wages, and employment while incorporating migration incentives. The discussion is based upon neoclassical labor supply and migration theory and informed by the conjectured economic effects from a normative perspective. This research suggests that a basic income would create migration incentives that reduce the tax base, leading us to question this policy’s feasibility. Moreover, the flow-on effects of migration call into question the justice of both residence-based and citizenship-based basic income schemes. Therefore, this article sheds light on how basic income’s feasibility and justice relate to each other and identifies the benefits and further opportunities for interdisciplinary social policy research.
An Anthropometric Study of Lung Donors
Authors: Suryapalam Manish , Kashem Mohammed , Zhao Huaqing , Shigemura Norihisa , Toyoda Yoshiya , Keshavamurthy Suresh
Published: July 2021

Purpose:

A difference in the lower body to upper body ratio between similarly heighted individuals could lead to inadequately matched transplants. There has been a perception in clinical circles that body ratio varies between people of different races, and investigating this supposition would prove useful in increasing transplant match accuracy. The investigation’s purpose was to derive an equation with a greater correlation to lung length than height alone.

Methods:

Lung transplantation donor data for 480 adult patients was obtained and divided by ethnicity—Caucasian, African American, and Hispanic. Height, weight, age, sex, right and left lung length were evaluated for significance. The R2 value of the multiple linear regression with these variables vs. lung length was determined and tested in a separate dataset of 100 patients.

Results:

Only the distribution of height was significant between the 3 ethnicities ( P = 0.041). None of the ANCOVAs were significant ( P < 0.05) or near significant ( P < 0.10). For the strongest correlation model with lung length, height had a linear fit, weight had a cubic fit, and age had a logistic fit. Multiple regression models were successfully created for right lung (R2 = 0.202) and left lung (R2 = 0.213). Independent testing showed a correlation of 0.131 and 0.136, respectively.

Conclusion:

Using demographic information from the donor and recipient as proxies for estimating lung size should only serve as a rough guide due to their weak correlation with lung length. As a result, for greater accuracy, donor-recipient matching should be individualized by taking donor and recipient chest X-Rays and/or TLC into consideration.
Sporting Scars
Authors: Thorpe Holly
Published: July 2021

Taking inspiration from the ethico-onto-epistemological implications of new materialisms, this poem is a modest and partial attempt at experimenting with new ways of bringing my sporting past-present-future together to reimagine feminist politics, vulnerabilities, and the implications of sporting policies that continue to reinforce gender binaries, harming, and excluding so many. This piece of writing was triggered—in a visceral and unexpected way—by a surge of transphobic discourse in Aotearoa New Zealand society in 2021, with groups of athletes, pseudo-feminists, doctors, politicians, and the public protesting transgender women’s rights to participate in sport at elite and community levels.
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53
Authors: Wang Liang , Xu Lei , Wang Yu
Published: July 2021

Cutaneous squamous cell carcinoma (CSCC) is a malignant tumor that originates from keratinocytes in the epidermis or appendage. Traditional Chinese medicine Huaier has anti-tumor activity in various malignancies. Little is known about the role of Huaier in CSCC. Here, we investigated the function of Huaier in CSCC. We treated CSCC cell line (SCL-1 and A431) with a series of concentration gradients of Huaier to examine the half maximal inhibitory concentration (IC50) of Huaier on SCL-1 and A431 cells. The IC50 of Huaier on growth of SCL-1 and A431 cells were 6.96 and 7.57 mg/mL, respectively. Moreover, Huaier reduced the methylation levels of CDKN2A and TP53, and enhanced the expression of CDKN2A and TP53 in SCL-1 and A431 cells in a dosage-dependent manner. The expression of DNA methyltransferase DNMT1 was severely repressed by Huaier treatment in SCL-1 and A431 cells. DNMT1 overexpression enhanced the methylation levels of CDKN2A and TP53, and suppressed the expression of CDKN2A and TP53 in Huaier-treated SCL-1 and A431 cells. Huaier treatment inhibited proliferation, migration, and invasion of SCL-1 and A431 cells. However, inhibition of CDKN2A or TP53 reversed the influence of Huaier treatment on proliferation, migration, and invasion of CSCC cells. In conclusion, our data demonstrate that Huaier inhibits proliferation, migration, and invasion of CSCC cells by regulating DNA methylation of CDKN2A and TP53, thereby attenuating the progression of CSCC. Thus, Huaier extract may act as a drug for treating CSCC.
Exploring epigenetic and microRNA approaches for γ-globin gene regulation
Authors: Starlard-Davenport Athena , Fitzgerald Ashley , Pace Betty S
Published: July 2021

Therapeutic interventions aimed at inducing fetal hemoglobin and reducing the concentration of sickle hemoglobin is an effective approach to ameliorating acute and chronic complications of sickle cell disease, exemplified by the long-term use of hydroxyurea. However, there remains an unmet need for the development of additional safe and effective drugs for single agent or combination therapy for individuals with β-hemoglobinopathies. Regulation of the γ-globin to β-globin switch is achieved by chromatin remodeling at the HBB locus on chromosome 11 and interactions of major DNA binding proteins, such as KLF1 and BCL11A in the proximal promoters of the globin genes. Experimental evidence also supports a role of epigenetic modifications including DNA methylation, histone acetylation/methylation, and microRNA expression in γ-globin gene silencing during development. In this review, we will critically evaluate the role of epigenetic mechanisms in γ-globin gene regulation and discuss data generated in tissue culture, pre-clinical animal models, and clinical trials to support drug development to date. The question remains whether modulation of epigenetic pathways will produce sufficient efficacy and specificity for fetal hemoglobin induction and to what extent targeting these pathways form the basis of prospects for clinical therapy.
Challenges in the Ethical Review of Clinical and Biomedical Research in Malaysia: A Mixed Methods Study
Authors: See Hooi Y. , Mohamed Mohd S. , Nor Siti N. M. , Low Wah Y.
Published: July 2021

Empirical evidence of the ethical review of clinical and biomedical research in Malaysia is limited. We have conducted a convergent mixed methods research, which comprises an online survey and semistructured interviews to examine the challenges in the ethical review of clinical and biomedical research. Data collected reveal that the ethics review process is inconsistent, duplicate, and inadequate. The results indicate a strong need for a centralized ethical review mechanism and a national system for mutual recognition of ethics reviews to improve the effectiveness and efficiency of the ethics review system in Malaysia. A joint research ethics committee review between Malaysia and sponsoring countries for multinational research should also be encouraged as it could address the concerns of the lack of expertise and training.
Friction additive manufacturing technology: A state-of-the-art survey
Authors: Gao Huangyu , Li Hongjun
Published: July 2021

Additive manufacturing as a major component of the “fourth Industrial Revolution” is getting more and more attention. Friction additive manufacturing technology (FAM) is a subdivision of additive manufacturing technology. Because of its solid-state characteristics, deposition by FAM shows better mechanical performance than other technologies such as powder bed fusion technologies. This paper presents a state-of-the-art survey on the development of FAM in three categories: (i) Friction stir additive manufacturing; (ii) Friction surfacing additive manufacturing; (iii) Metal powder assisted additive manufacturing. The underlying principles, process parameters, microstructure, mechanical properties, and existing problems are described and discussed in detail.
R-Function and variation method for bending problem of clamped thin plate with complex shape
Authors: Xia Fengfei , Li Shanqing
Published: July 2021

Solving ordinary thin plate bending problem in engineering, only a few analytical solutions with simple boundary shapes have been proposed. When using numerical methods (e.g. the variational method) to solve the problem, the trial functions can be found only it exhibits a simple boundary shape. The R-functions can be applied to solve the problem with complex boundary shapes. In the paper, the R-function theory is combined with the variational method to study the thin plate bending problem with the complex boundary shape. The paper employs the R-function theory to express the complex area as the implicit function, so it is easily to build the trial function of the complex shape thin plate, which satisfies with the complex boundary conditions. The variational principle and the R-function theory are introduced, and the variational equation of thin plate bending problem is derived. The feasibility and correctness of this method are verified by five numerical examples of rectangular, I-shaped, T-shaped, U-shaped, and L-shaped thin plates, and the results of this method are compared with that of other literatures and ANSYS finite element method (FEM). The results of the method show a good agreement with the calculation results of literatures and FEM.
Developing research knowledge and capability in undergraduate nurses: evaluation of targeted placements
Authors: Menzies Julie C , Emms Karl , Valler Tracey
Published: July 2021

Background

There are few opportunities for undergraduate nurses to undertake experiential learning about research design and conduct. The project aim was to implement and evaluate a placement to support the development of research knowledge and skills.

Methods

Establishment of a four-week placement, with allocation to a registered quality improvement/service evaluation project. Evaluation was obtained through questionnaires; student experience (pre, post and one year), supervisor experience and organisational impact (presentations, conference and grant submissions).

Results

24 students (five cohorts) were allocated to 17 projects (2017–2019). 100% of students enjoyed the placement, gained research knowledge and insight into clinical care. At one year ( n = 15), 88% of students would consider undertaking a service evaluation and 65% ( n = 11) would consider further post-graduate study. All supervisors ( n = 20) reported the initiative valuable for student development. All project results were shared with relevant local teams to enable service planning and results from five projects been presented at eight national and international conferences. Three projects have contributed directly to further research grant submissions.

Conclusion

The programme supports the development of undergraduate nurses to be research ready and facilitates organisations to address high-priority safety and quality topics. Further resources are required to be able to increase placement capacity.
Comparing individual and collective management of referential choices in dialogue
Authors: Knutsen Dominique , Fossard Marion , Achim Amélie M
Published: July 2021

Past research shows that when a discourse referent is mentioned repeatedly, it is usually introduced with a full noun phrase and maintained with a reduced form such as a pronoun. Is this also the case in dialogue, where the same referent may be introduced by one person and maintained by another person? An experiment was conducted in which participants either told entire stories to each other or told stories together, thus enabling us to contrast situations in which characters were introduced and maintained by the same person (control condition) and situations in which the introduction and the maintaining of each character were performed by different people (alternating condition). Story complexity was also manipulated through the introduction of one or two characters in each story. We found that participants were less likely to use reduced forms to maintain referents in the alternating condition. The use of reduced forms also depended on the context in which the referent was maintained (in particular, first or second mention of a character) and on story complexity. These results shed light on how the pressure to signal understanding to one’s conversational partner affects referential choices throughout the interaction.
In the hands of the beholder: Wearing a COVID-19 mask is associated with its attractiveness
Authors: Dudarev Veronica , Manaligod Maria GM , Enns James T , Todd Rebecca M
Published: July 2021

Protective facial masks reduce the spread of COVID-19 infection and save lives. Yet a substantial number of people have been resistant to wearing them. Considerable effort has been invested in convincing people to put on a mask, if not for their own sake than for those more vulnerable. Social and cognitive psychologists know that use and liking go both ways: people use what they like, and they like what they use. Here we asked whether positive attitudes towards facial masks were higher in those who had been wearing them longer. We asked participants in a diverse sample ( N = 498 from five countries and more than 30 US states) to rate how attractive and emotionally arousing masks and other objects associated with COVID-19 were in comparison to neutral objects, as well as reporting on their mask-wearing habits. To confirm reliability of findings, the experiment was repeated in a subset of participants 8–10 weeks later. The findings show that regular use of protective masks was linked to their positive appraisal, with a higher frequency and a longer history of wearing a mask predicting increased mask attractiveness. These results extended to other COVID-related objects relative to controls. They also provide critical ecological validity for the idea that emotional appraisal of everyday objects is associated with our experience of using them. Practically, they imply that societal measures to encourage mask wearing may have contributed to positive emotional appraisals in those who put them on, whether due to personal choice or societal pressure.
A prospective population-based study of stroke in the Central Region of Iran: The Qom Incidence of Stroke Study
Authors: Aghaali Mohammad , Yoosefee Sadegh , Hejazi Seyed Amir , Shuaib Ashfaq , Rahimi Maryam , Razavinia Fatemeh Sadat , Radmard Fatemeh , Sabokbar Tayebeh , Sharifipour Ehsan
Published: July 2021

Objective

Based on the few population-based studies that have been conducted in the Middle East, we determined the incidence of stroke in Qom, one of the central provinces of Iran.

Methods

The Qom province includes an estimated at-risk population of about 1 million. During a 12-month period (November 2018–November 2019), all first-ever strokes occurring in the target population were registered. Hospitalized cases were ascertained by discharge codes. Out-of-hospital cases were ascertained by a prospective screening of emergency medical services, emergency departments, ambulances records, primary care clinics, rural and urban public health centers, primary care physician offices, and neurologists’ offices. Crude and age-adjusted incidence rates (per 100,000 person-years) were calculated.

Results

During the study period, 1462 first-ever strokes occurred with a mean age of 68.1 (17–103) years; of these 45.2% were females (661 cases). The crude annual incidence rate per 100,000 at-risk populations was 145.4 (95% confidence interval, 138.1–153.0) for all types of stroke (156.5 for males and 134.3 for females), 26.4 (95% confidence interval, 23.5–29.8) for hemorrhagic stroke, and 114 (95% confidence interval, 105–121) for ischemic stroke. The incidence rate adjusted to the world population was 201.4 (95% confidence interval, 193–210) per 100,000 at-risk populations (adj incidence, 218.5 for males vs 187.4 for females). The total fatality rate during the first 28 days was 19.6%.

Conclusion

This study states that in this region there is a high incidence of stroke, which occurs at a younger age than the global average. There was a high prevalence of underlying stroke risk factors.
Medial femoral trochlea flap reconstruction versus proximal row carpectomy for Kienböck’s disease: a morphometric comparison
Authors: Van Handel Amelia C. , Lynch Leigha M. , Daruwalla Jimmy H. , Higgins James P. , Allen Kari L. , Pet Mitchell A.
Published: July 2021

Surgical options for advanced Kienböck’s disease include proximal row carpectomy or lunate reconstruction with a medial femoral trochlea osteochondral flap. This study compares morphology of the proximal capitate and the medial femoral trochlear surfaces to the proximal lunate using three-dimensional geometric morphometric analysis. Virtual articular surfaces were extracted from MRI studies of ten healthy volunteers. Distances between corresponding points on the proximal lunate and proximal capitate or medial femoral trochlear surfaces were measured. In seven subjects, mean inter-surface distance for the medial femoral trochlea–proximal lunate pair was significantly lower than the proximal capitate–proximal lunate pairing. In three subjects, mean proximal capitate–proximal lunate distance was significantly lower. We conclude that the medial femoral trochlear flap was anatomically closer to the shape of the proximal lunate in the majority of the examined subjects. However, we found that in three out of ten cases, the proximal capitate was a better match.
The Role of Regional Disease and Patterns of Treatment Failure in Primary Sinonasal Malignancies
Authors: Meerwein Christian M. , Balermpas Panagiotis , Vital Domenic G. , Broglie Martina A. , Soyka Michael B. , Holzmann David
Published: July 2021

Background

The question how to treat the clinically negative neck in sinonasal malignancies is controversial.

Objectives

To investigate patterns of treatment failure and to assess outcome measures in patients with primary sinonasal malignancies.

Methods

Retrospective cohort study of patients treated for primary malignant sinonasal malignancies.

Results

Lymph node (LN) metastases at initial presentation were present in 8 of 152 patients (5.3%). Ipsi- and contralateral LN levels 1 and 2 were identified as nodal basins at risk. We found a 5-year overall survival (OS) of 75.2% and disease free survival of 61.1%. Among patients with cN0 neck, nodal recurrence free survival was not different between patients with and without elective neck treatment ( P  =  .23). On logistic regression analysis, we found initial T classification as an independent factor for achievement of complete remission (CR) and OS.

Conclusions

LN metastases at initial presentation are rare and initial T classification was identified as the most important prognostic factor for OS and CR, emphasizing the need for a thorough initial staging of the primary tumor.
Possible pharmacogenetic factors in clozapine treatment failure: a case report
Authors: Whiskey Eromona , Romano Graziella , Elliott Matilda , Campbell Malcolm , Anandarajah Cholan , Taylor David , Valsraj Koravangattu
Published: July 2021

There is still much to learn about the predictors of therapeutic response in psychiatry, but progress is gradually being made and precision psychiatry is an exciting and emerging subspeciality in this field. This is critically important in the treatment of refractory psychotic disorders, where clozapine is the only evidence-based treatment but only about half the patients experience an adequate response. In this case report, we explore the possible biological mechanisms underlying treatment failure and discuss possible ways of improving clinical outcomes. Further work is required to fully understand why some patients fail to respond to the most effective treatment in refractory schizophrenia. Therapeutic drug monitoring together with early pharmacogenetic testing may offer a path for some patients with refractory psychotic symptoms unresponsive to clozapine treatment.
Lung microbiota dysbiosis and the implications of SARS-CoV-2 infection in pregnancy
Authors: Ezechukwu Henry C. , Diya Cornelius A. , Egoh Ifunanya J. , Abiodun Mayowa J. , Grace John-Ugwuanya A. , Okoh God’spower R. , Adu Kayode T. , Adegboye Oyelola A.
Published: July 2021

There are a great number of beneficial commensal microorganisms constitutively colonizing the mucosal lining of the lungs. Alterations in the microbiota profile have been associated with several respiratory diseases such as pneumonia and allergies. Lung microbiota dysbiosis might play an important role in the pathogenic mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as elicit other opportunistic infections associated with coronavirus disease 2019 (COVID-19). With its increasing prevalence and morbidity, SARS-CoV-2 infection in pregnant mothers is inevitable. Recent evidence shows that angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) act as an entry receptor and viral spike priming protein, respectively, for SARS-CoV-2 infection. These receptor proteins are highly expressed in the maternal-fetal interface, including the placental trophoblast, suggesting the possibility of maternal–fetal transmission. In this review, we discuss the role of lung microbiota dysbiosis in respiratory diseases, with an emphasis on COVID-19 and the possible implications of SARS-CoV-2 infection on pregnancy outcome and neonatal health.
Knowledge, attitude, and utilization of drugs toward COVID-19 pandemic among Bale Zone residents, Southeast Ethiopia
Authors: Mamo Ayele , Hassen Mesud M , Adem Ahmednur , Teferu Zinash , Kumbi Musa , Husen Abduljewad , Solomon Damtew , Lette Abate , Hailu Sintayew , Sinba Edao , Abduletif Abdushakur M , Kassim Jeylan , Walle Gashaw , Atlaw Daniel
Published: July 2021

Background:

Coronavirus disease is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2, which poses therapeutic dilemmas. Some suggestions for drug treatment seem problematic. Beliefs about the causes of health problems are determinants of treatment seeking decisions. Hence, one of the alternatives for the solution of health problems is employing traditional medicine to prevent coronavirus disease 19.

Objective:

To assess the knowledge, attitude, and utilization of drugs toward the coronavirus disease 19 pandemic among Bale zone residents.

Methods:

Community-based cross-sectional study was conducted among the Bale Zone population from May 30 to June 30, 2020. Eight hundred fifty-four participants were selected using a single population formula, and a multistage sampling technique was employed. Data were analyzed using SPSS version 25.0. Descriptive and binary logistic regression was used to analyze the outcomes. A p value ⩽ 0.05 was considered statistically significant.

Results:

Out of the total 854 respondents, about 534 (62.5%) got information about coronavirus disease 19 from TV/radio. More than two-thirds (71.9%) of the respondents have known that severe acute respiratory syndrome coronavirus 2 has no curative drugs, and 65.4% had a more appropriate attitude toward overall drug use in coronavirus disease 19. Level of education and, attitude towards drug use were singnificantly associated with knowledge of drugs, source of information about coronavirus disease 19 and having good practice were significantly associated with atittude toward drug utilization.

Conclusion:

One out of two study participants have good knowledge regarding drugs to the coronavirus disease 19 pandemic. Illiterate people in the community were identified to have poor knowledge about drugs, hence community educuation program is important to improve the knowledge about drugs towards the coronavirus disease 19 pandemic.
Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation
Authors: Datta Shaishav , Fitzpatrick Aisling M , Haykal Siba
Published: July 2021

Vascularized composite allotransplantation represents the final level of the reconstructive ladder, offering treatment options for severe tissue loss and functional deficiencies. Vascularized composite allotransplantation is particularly susceptible to ischemia–reperfusion injury and requires preservation techniques when subjected to extended storage times prior to transplantation. While static cold storage functions to reduce ischemic damage and is widely employed in clinical settings, there exists no consensus on the ideal preservation solution for vascularized composite allotransplantation. This review aims to highlight current clinical and experimental advances in preservation solution development and their critical role in attenuating ischemia–reperfusion injury in the context of vascularized composite allotransplantation.
Management of severe baclofen toxicosis using hemodialysis in conjunction with mechanical ventilation in a cat with chronic kidney disease
Authors: Hoffman Levi , Londoño Leonel A , Martinez Jenifer
Published: July 2021

Case summary

A 2-year-old castrated male domestic shorthair cat was presented for evaluation of acute and progressive neurologic signs 2–4 h after exposure to baclofen. The suspected ingested dose was 2.1 mg/kg. On admission, the cat was tetraplegic with stuporous mentation, and venous blood gas analysis showed mild hypercapnia (PvCO2 43.4 mmHg) raising concern for hypoventilation. Owing to the acute nature of the ingestion, severity of the clinical signs and reported history of chronic kidney disease, hemodialysis was recommended to remove the toxin. A 5 h hemodialysis session was performed using an intermittent platform without hemoperfusion. At the beginning of hemodialysis, worsening hypoventilation and hypercapnia (PvCO2 88.6 mmHg) required endotracheal intubation and manual ventilation initially, followed by mechanical ventilation. At the end of the dialysis session, the cat was breathing spontaneously and disconnected from the ventilator. The cat was ambulatory and alert 1 h after the end of dialysis. After an additional 12 h of monitoring, the cat had full return of neurologic function and was discharged from hospital. Serum baclofen concentration measured prior to, during and after hemodialysis showed a 77.7% reduction in baclofen levels immediately after hemodialysis.

Relevance and novel information

This is the first report of baclofen toxicity in a cat successfully treated with hemodialysis and mechanical ventilation simultaneously. Treatment with hemodialysis therapy and mechanical ventilation could be considered in cases of acute baclofen toxicosis to improve outcome and reduce the length of the hospital stay.
From Contact Prevention to Social Distancing: The Co-Evolution of Bilingual Neologisms and Public Health Campaigns in Two Cities in the Time of COVID-19
Authors: Wang Xiaowen , Huang Chu-Ren
Published: July 2021

This article investigates the evolution of social distancing terms in Chinese and English in two geographically close yet culturally distinct metropolitan cities: Hong Kong and Guangzhou. This study of bilingual public health campaign posters during the COVID-19 pandemic focuses on how the evolution of neologisms and linguistic strategies in public health campaigns adapts to different societal contexts. A baseline meaning of the re-purposed linguistic expressions was established according to the BNC corpus for English and the Chinese Gigaword Corpus for Chinese. To establish the link between linguistic expressions and public health events, we converted them to eventive structures using the Module-Attribute Representation of Verbs and added interpersonal meaning interpretations based on Systemic Functional Linguistics. The two cities are found to have taken divergent approaches. Guangzhou prefers “contact prevention” with behavior-inhibiting imperatives and high value modality. Conversely, the original use of “contact prevention” in Hong Kong was gradually replaced by the neologism social distancing in English, triggering competing loan translations in Chinese. In Hong Kong, behavior-encouraging expressions are predominantly used with positive polarity and varying modality and mood devices, which fluctuate to track the epidemic curve of COVID-19. We conclude that lexical evolution interacts with social realities. Different speech acts, prohibition in Guangzhou but advice and warning in Hong Kong, are constructed with a careful bilingual reconfiguration of eventive information, mood, modality, and polarity to tactfully address the social dynamics in the two cities.
Book review: Cultures, Citizenship and Human Rights, Rosemarie Buikema, Antoine Buyse and Antonius C. G. M. Robben, Electronic edition, Routledge, Abingdon, 2020
Authors: Okhade Sonal
Published: July 2021

Cultures, Citizenship and Human Rights, Rosemarie Buikema, Antoine Buyse and Antonius C. G. M. Robben, Electronic edition, Routledge, Abingdon, 2020, pp. 268 (Paperback), £36.99 (Kindle Edition).