bluuebunny/crossref_metadata_2025 huggingface dataset:
Toward the Next Generation of Research in Adult Literacy Instruction
Authors: Clark-Stallcamp Rebecca , Lockee Barbara
Published: December 2024

In November 2019, the Program for the International Assessment of Adult Competencies (PIAAC) from 2017 (Institute of Education Sciences [IES], 2019) depicted no significant change in the concerning status of adult literacy in the US. More than 52% of adults between 16 and 45 scored below functionally literate levels. While shortcomings are attributed to various factors such as high attrition rates in program, ill-conceived policy planning, and more, significant focus is placed on the impact of effective instruction. The study reviews core cognitive component theory experimentation and instructional intervention research in adult literacy to explain contributions and limitations in current research. To address limitations in research, the review further emphasizes the interdisciplinary role instructional design and technology, and associated research methods such as design-based research that may offer future research on instructional interventions for Adult Basic Education literacy.
PRAVOPIS A JAZYKOVÁ STAVBA POHREBNÝCH VERŠOV JÁNA MIČÁTKA V ZBIERKE MORENA
Authors: Zvalená Eleonóra , Marčoková Daniela
Published: December 2024

V evanjelickom prostredí sa pohrebné básne stali neodmysliteľnou súčasťou rozlúčky so zosnulým najmä koncom 18. storočia a v 19. storočí. Kysáčsky učiteľ a národovec Ján Mičátek zaznamenal 42 prevažne autorských valedikcií písaných v biblickej češtine a dobovej slovenčine. Zhrnuté sú v rukopisnej zbierke Morena Čili odobierky pri príležitostách pohrebních V cirkvách ev. dla A. vyz. v úžitku V národe Slovenskom. Z vätša póvodne spísal a skladal Ján Mičátek slovenský národní učitel na Kisáči V Srbskej Vojvodine Roku Pána 1862. Tieto pohrebné básne ako dôležitý historický prameň sú integrálnou súčasťou dobového recepčného horizontu a majú predovšetkým literárnohistorickú, ale aj etnografickú hodnotu. Prvoradým cieľom našej práce bolo zistiť, v akej miere sa v pohrebných veršoch prelínajú biblická čeština a dobová slovenčina. Výskum bol zameraný na excerpovanie a analýzu najreprezentatívnejších jazykových javov príznačných pre cirkevné písomnosti slovenskej vojvodinskej inteligencie a uplatnili sme v ňom nasledujúce vedecké metódy: deskriptívnu, kvalitatívnu, explanačnú a konfrontačnú. Pohrebná zbierka Morena predstavuje z jazykového hľadiska prelínanie tradičných českých a živých dobových slovenských prvkov, ktoré svedčia o vzdelanosti a rozhľadenosti Jána Mičátka, súdobého slovenského vzdelanca.
PRIZIVANJE DUHOVA PROŠLOSTI – KALEIDOSKOP SEĆANJA U FILMSKOM OSTVARENJU „BOL I SLAVA” (2019)
Authors: Maričić Mesarović Sanja , Smuđa Gordana
Published: December 2024

Rad se bavi filmskim ostvarenjem „Bol i slava” (šp. Dolor y gloria) iz 2019. godine proslavljenog španskog režisera Pedra Almodovara. Reč je o njegovom najličnijem i najintimnijem filmu (Labarthe, 2022) čija radnja prati priču o filmskom reditelju i scenaristi na zalasku karijere koji preispituje svoj život, iskušenja i očekivanja nakon postignute slave. U ovom radu film posmatramo kao tekst koji je zasnovan na scenariju te u analizi tragamo za flešbekovima, tehnikom vraćanja radnje u prošlost dok protagonista rekonstruiše svoj život kroz epizode iz različitih životnih perioda. Bol na koju aludira naslov filma je i fizička i duševna, a postignuta slava ne toliko oslobađajuća. Shvatamo da slavu neminovno prati i bol. Budući da nalazimo podudaranja u životu samog režisera i životu njegovog protagoniste, u istraživanju se bavimo i autofikcijom.
KONSEPTUALISASI FUNGSI-FUNGSI MANAJEMEN PENDIDIKAN PROFETIK DALAM AL QUR’AN; KAJIAN AYAT-AYAT KISAH NABI SULAIMAN AS
Authors: Razak Abdul , Tanzeh Ahmad
Published: December 2024

This research aims to conceptualize the functions of prophetic educational management as contained in the Qur'an, particularly through the study of verses that narrate the story of Prophet Solomon (AS). Utilizing the content analysis research method, this study identifies and elaborates on the educational management principles applied by Prophet Solomon (AS), which include planning, organizing, implementing, and monitoring functions. In terms of planning, Prophet Solomon (AS) is known for his ability to formulate clear strategies and goals. Organizing is evident from his ability to structure his government and distribute tasks effectively. The implementation function is reflected in his ability to make decisions and implement policies wisely. Meanwhile, monitoring is conducted through strict control and evaluation mechanisms to ensure that tasks are executed according to plan. The findings indicate that the story of Prophet Solomon (AS) in the Qur'an provides practical and philosophical guidance relevant to the development of modern educational management. This study is expected to contribute theoretically to the field of Islamic education and offer a new perspective for education practitioners in implementing prophetic values in their educational management.
POLICY ON STRENGTHENING CHARACTER EDUCATION AT MADRASAH ALIYAH DARUL AMIN, KUTACANE, SOUTHEAST ACEH
Authors: Putri Musdalipah , Hasmiani
Published: December 2024

Character education is the main foundation in shaping the personality and morals of the younger generation in Indonesia. This study uses a qualitative descriptive method with field studies to understand and describe the process of character building at this madrasah. The research findings indicate that the implementation of Islamic religious education policies at MA Darul Amin plays a significant role in enhancing the students' religious character and noble morals. Programs such as daily worship routines, character education based on Islamic values, Islamic extracurricular activities, and an Islamic school environment contribute to the character formation of students. Strengthening the role of teachers as role models and collaboration with parents and the community are also key factors in the success of this program. This study found that Islamic religious education at MA Darul Amin not only enhances students' spirituality but also strengthens their social awareness. The implementation of this policy shapes students who not only excel academically but also possess good character and are ready to contribute positively to society. This research contributes to the development of Islamic religious education policies in Southeast Aceh and the improvement of the quality of education at MA Darul Amin Kutacane.
Construction d'un petit pont forestier au Pérou
Authors: Calonder K.
Published: December 2024

L'ingéniosité et le travail acharné peuvent souvent compenser l'insuffisance des ressources financières et matérielles. Un exemple est décrit dans cet article.Pour faciliter l'accès à un village près d'Iquitos au Pérou, l'auteur a construit un pont forestier. Ce petit ouvrage, qui traverse une dépression inondée pendant la saison des pluies, était destiné non seulement à offrir un raccourci aux villageois, mais aussi à être utilisé par les camions transportant du bois de chauffage.Les différentes étapes du projet sont brièvement passées en revue
Les erreurs dans les dénominations commerciales des bois tropicaux
Authors: Détienne Pierre
Published: December 2024

Les utilisateurs de bois tropicaux peuvent interroger le Service d'Anatomie des Bois du C.T.F.T. pour deux raisons principales : soit ils sont en possession d'une espèce dont le nom est inconnu, soit l'aspect et le comportement d'une bille ou d'une pièce de bois ne semblent pas correspondre au nom sous lequel le bois en question est classé.Les causes des erreurs peuvent être recherchées dans l'abattage, les manutentions ou les formations de lots. Il arrive également que les noms ne soient pas correctement reportés d'un stade de transformation à l'autre. Des noms erronés peuvent malheureusement être attribués intentionnellement.Sur la base des observations et des recherches qu'ils ont effectuées, les spécialistes du C.T.F.T. ont établi un tableau reprenant quelques bois qu'ils ont récemment analysés et qui ont été mal nommés. Les noms corrects sont repris dans ce tableau.
THE ROLE OF FED SPEECH SENTIMENT SIGNALS IN SHAPING US MARKET RESPONSE
Authors:   NUST Business School National University of Sciences and Technology (NUST), Pakistan, Arshad Asma
Published: December 2024

The Federal Reserve's communication shapes US investor decisions and market dynamics. This paper examines the impact of the Fed governor speeches' sentiments signals on the US equity market performance from June 1996 to Sep 2023. The sentiment index is calculated using individual Lexicon dictionaries (AFINN, Bing, NRC, and Loughran McDonald) and their combined PCA scores. Our findings revealed a negative relationship suggesting that a positive (negative) sentiment brings a significant decrease (increase) in the cumulative abnormal return on the event window (+2). These results provide valuable insights into the dynamic nature of the US equity market in response to the Federal Reserve’s communication for regulators, policymakers, and other stakeholders of the equity market.
Formulation And Test Effectiveness Of Antifungal Cream Of Mugwort Ethanol Extract (Artemisia vulgaris L) On Candida Albicans ATCC 10231
Authors: Sulthon Aziz Yaya , Naila Matsna Assyifa  , Amalia Rahma Pratiwi  , Siska Tri Wahyuni
Published: December 2024

Menurut masyarakat Suku Tengger secara turun temurun, tanaman mugwort(Artemisia vulgaris L.) bermanfaat sebagai pengobatan infeksi jamur. Berdasarkan laporan penelitian yang telah dilakukan, tanaman mugwort(Artemisia vulgaris L.) mengandung senyawa bioaktif berupa flavonoid, tanin, saponin, steroid, alkaloid. Senyawa aktif tersebut memiliki aktivitas sebagai antijamur. Penelitian ini bertujuan untuk memformulasi, mengevaluasi serta menguji aktivitas sediaan krim dengan tipe M/A ekstrak etanol daun mugwort (Artemisia vulgaris L.) dalam menghambat pertumbuhan jamur Candida albicans ATCC 10231. Jenis penelitian ini adalah penelitian eksperimen laboratorium. Sampel diambil secara simple random sampling untuk dilakukan uji daya hambat terhadap jamur Candida Albicans ATCC 10231. Hasil uji mutu fisik krim ekstrak daun mugwort (Artemisia vulgaris L.) dari keempat formulasi dengan parameter uji meliputi uji organoleptis, uji pH, uji daya sebar, uji daya lekat, dan uji viskositas sudah sesuai standar mutu yang ditetapkan. Hasil evaluasi fisik sediaan krim antijamur memperlihatkan orgnoleptic, homogenitas, Ph 6, uji daya sebar F1 5,2 cm, FII 5,1 cm, FIII 5,3 cm, dan FIV 5,4 cm, uji daya lekat FI 5,3 detik, FII 5,3 detik, FIII 5,4 detik, dan FIV 5,5, Sedangkan pada uji viskositas hasil FI 24.606 cP, FII 30.836 cP, FIII 40.198 cP, dan FIV 38.695 cP. Data hasil daya hambat akan dianalisis dengan rata-rata dalam setiap konsentrasinya yang dilakukan sebanyak tiga kali replikasi. Hasil pengamatan menunjukkan bahwa sediaan krim ekstrak etanol daun mugwort(Artemisia vulgaris L.) memiliki efektivitas antijamur dengan nilai rata-rata 8,6 mm pada konsentrasi 2,5% (kategori sedang), 10,3 mm pada konsentrasi 5% (kategori kuat), 11 mm pada konsentrasi 10% (kategori kuat) dan 12 mm pada konsentrasi 20% (kategori kuat). Kesimpulan dari penelitian ini adalah sediaan krim ekstrak etanol daun mugwort(Artemisia vulgaris L.) dapat menghambat pertumbuhan jamur Candida Albicans ATCC 10231.
Formulasi Sediaan Masker Clay Kombinasi Ekstrak Daun Pepaya (Carica papaya L.) Dan Daun Sirsak (Annona muricata L.)
Authors: Alfiraza Ery Nourika , Endang Istriningsih  , Nadiyya Rizka Maulana
Published: December 2024

Salah satu jenis produk kosmetik yang digunakan untuk merawat kulit wajah adalah masker. Clay adalah bahan mineral yang terbuat dari tanah liat, terutama kaolin dan bentonit. Tujuan penelitian ini adalah untuk mengetahui kombinasi masker ekstrak daun pepaya dan daun sirsak dengan menggunakan konsentrasi F0 (0:0), FI (2:6), FII (4:4), dan FIII (6:2). Penelitian ini menggunakan pendekatan eksperimen, yang dimulai dengan menyiapkan sediaan masker dan kemudian melakukan evaluasi sediaan masker. Hasil analisis data One Way Anova menunjukkan bahwa nilai sig 0,000 < 0,05, yang berarti H0 ditolak. Hasil uji organoleptik, pH, homogenitas, daya sebar, daya lekat, waktu kering, viskositas, iritasi, dan stabilitas menunjukkan bahwa seluruh konsentrasi formulasi memenuhi persyaratan. Hasil ini menunjukkan bahwa daun pepaya dan ekstrak sirsak dapat dibuat dalam sediaan masker clay.
Role of Vitamin D and E as Antioxidants Against Cerebral Endothelial Dysfunction: An In Vivo Study in White Rats (Rattus norvegicus) Sepsis Model
Authors: Fajri Fauzan , Fajar Sukmawan , Hasan Denny Irmawati , Dimiati Herlina , Amna Eka Yunita , Sovira Nora , Anidar Anidar , Safri Mulya , Gunawan Aris
Published: December 2024

Sepsis is a life-threatening condition caused by the body's response to an infection, leading to organ dysfunction. A antioxidants can help neutralize harmful free radicals that cause cellular and tissue damage through oxidative stress. Vitamin D and E are two antioxidants that have been extensively studied for their potential effectiveness. This study aims to evaluate the effectiveness of vitamins D and E in reducing oxidative stress in the cerebral vascular endothelial cells of Wistar mice in a sepsis model. The study follows an experimental design and uses a posttest with a control group. The levels of NO and SOD in 24 sepsis model mice were measured using ELISA, and the cerebral endothelial tissues were examined histopathologically. An ANOVA test was performed, followed by the Post Hoc LSD test. NO and SOD levels decreased in sepsis rats from 66.88 ± 16.59 to 88.77 ± 12.83µmol/L. Sepsis mice given vitamin D and E showed significant results on changes in NO and SOD levels (p<0.05). Based on the histopathological results of necrosis, inflammation, and hemorrhagic cell damage in sepsis rats reached over 50% of the field of view, significantly different from sepsis mice that had been given vitamin D and E. Sepsis mice were given vitamin D and E influenced 96.2% and 98.7% on changes in NO, SOD, and cerebral endothelial dysfunction (p<0.05). These findings imply that vitamins D and E may be beneficial in managing sepsis-induced cerebral endothelial dysfunction, potentially impacting the treatment and outcomes of sepsis patients.
Monkey Pox Symptom Identification, Cause, Treatment and Infection Control Prevention
Authors: Wandira Vicia Dara , Syach Rifki Adrian
Published: December 2024

Monkey pox is a zoonotic disease that is re-emerging and proliferating in areas where it has not been observed for decades. Monkey pox outbreaks have been documented periodically in the past. Significant outbreaks occurred in Nigeria during 2017-2018, as well as in the United States and Nigeria. The research method used was a literature evaluation, specifically covering literature collected from multiple sources relating to monkey pox disease. Monkey pox is caused by the monkey pox virus. The disease is endemic in Central and West Africa. Human cases have recently spread to additional locations. No cases of monkey pox have been reported in Indonesia. Monkey pox in humans has similarities to smallpox; however, the symptoms are usually less severe. The monkey pox virus is present in skin lesions and in throat and nasopharyngeal swabs. Monkey pox is self-limiting. Treatment is palliative. Transmission of the disease can be reduced by avoiding direct contact with wild animals. In conclusion, monkey pox is a zoonotic disease caused by the monkey pox virus. The disease is self-limiting. The treatment given is symptomatic. The recommended method to prevent transmission is to avoid contact with sick individuals or animals.
Potential Combination of Dayak onion Eleutherine palmifolia L. and Chrysanthemum flower Chrysanthemum indicum L. as Anti-aging: Network Pharmacology Approach
Authors: Fitriyani  , Salsabila Eka Setia Ningrum  , Roihatul Mutiah
Published: December 2024

Background: An anti-aging agent is a preparation or product used to inhibit skin aging. Aging occurs because of cell damage caused by free radicals. Therefore, anti-aging agents, which contain antioxidants to inhibit oxidative stress caused by free radicals, are needed. Dayak onion (eleutherine palmifolia (L) Merr.) and chrysanthemum flowers (Chrysanthemum indicum L.) have high antioxidant content, which has the potential to inhibit aging. Objective: To determine the anti-aging potential of dayak onion and chrysanthemum flower compounds Methods: Network pharmacology was performed using GeneCards (https://www.genecards.org) to obtain target genes, Cytoscape v3.10.1 software (https://cytoscape.org), DisGeNET (https://www.disgenet.org), STRING (https://www.string-db.org/), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) PATHWAY (https://www.genome.jp/kegg/pathway.html). Results: Based on Network Pharmacology, dayak onion and chrysanthemum flowers showed that 14 of the 200 target proteins were involved in biological processes and signaling pathways for premature aging syndrome. Conclusion: The combined compound from dayak onion and chrysanthemum flower has anti-aging activity due to seven bioactive components in the hydroxycinnamic acid group. This compound influences biological processes and longevity by regulating the CAD, SIRT1, and TP53 signaling pathways. Therefore, the combination of dayak onion and chrysanthemum flowers has potential as an anti-aging agent.
COMPLETE UNILATERAL CLEFT LIP SURGERY USING MODIFIED ROTATION-ADVANCEMENT FLAP TO ENHANCE AESTHETIC APPEARANCE IN RSPAL DR. RAMELAN HOSPITAL: A CASE SERIES
Authors: Hadikhosuma Jessica Novia , Wicaksono Bambang , Dhiparedja Rionaldo
Published: December 2024

ABSTRACT
Introduction: Unilateral cleft lip is a common congenital anomaly that impacts both the appearance and function of the upper lip and nose. Surgical cleft lip repair aims to return the affected structures to their normal anatomy and functionality. In recent years, several advances have been made in cleft lip repair, including new surgical techniques and approaches. In this current study, authors have adapted Millard's rotation-advancement flap technique and further modified it throughout his 14 years of experience.
Case Presentation: This case series included 4 patients at RSPAL Dr Ramelan Hospital between September 2023 and February 2024, focusing only on complete unilateral cleft lip repair using the modified rotation-advancement flap. The surgery techniques and outcomes of the surgeries, including aesthetic improvements and functional outcomes, are discussed. This case series highlights the effectiveness of the modified techniques in achieving satisfactory results for patients with complete unilateral cleft lips, contributing to their overall well-being and quality of life.
Conclusion: The modified rotation-advancement flap represents a valuable approach for complete unilateral cleft lip repair, providing satisfactory outcomes in aesthetics and function. Further research, long-term follow-up studies, and larger sample sizes are needed to validate its effectiveness and refine surgical techniques.
 
Keywords: Cleft lip surgery, complete unilateral cleft lip, modified rotation-advancement flap.
Epigenetic and epitranscriptomic regulations of metabolic dysfunction-associated steatotic liver disease
Authors: Zheng Qiantao , Rui Liangyou
Published: December 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by excessive hepatic lipid accumulation and can progress to metabolic dysfunction-associated steatohepatitis (MASH), which is manifested with persistent liver injury, inflammation, and fibrosis, increasing the risk for cirrhosis and hepatocellular carcinoma. Aberrant epigenetic reprogramming and epitranscriptomic remodeling emerge to be a driving force for MASLD and MASH. SNAIL1 and SLUG, two related transcriptional regulators, regulate de novo lipogenesis and liver steatosis by opposing epigenetic mechanisms. RNA m6A modification regulates not only liver steatosis but also liver injury and regeneration. MASLD is associated with changes in the expression of m6A writers, erasers, and readers, which significantly influence its progression.
Améliorer conjointement la santé et le bien-être des animaux dans la transition des systèmes d’élevage vers la durabilité
Authors: DUCROT Christian , BARRIO Maria Belén , BOISSY Alain , CHARRIER François , EVEN Sergine , MORMÈDE Pierre , PETIT Sandrine , PINARD-VAN DER LAAN Marie-Hélène , SCHELCHER François , CASABIANCA François , DUCOS Alain , FOUCRAS Gilles , GUATTEO Raphaël , PEYRAUD Jean-Louis , VAYSSIER-TAUSSAT Muriel , VEYSSET Patrick , FRIGGENS Nicolas C. , FERNANDEZ Xavier
Published: December 2024

Cet article présente les travaux et les recherches à conduire pour placer la santé et le bien-être au cœur de la transition agroécologique des systèmes d’élevage. Il souligne la nécessité de considérer la santé dans une perspective plus large qu’aujourd’hui et la question des expériences émotionnelles positives en matière de bien-être. Les interactions positives entre santé et bien-être mais aussi les tensions possibles entre ces deux dimensions sont discutées. L'amélioration conjointe de la santé et du bien-être des animaux pose des questions à différentes échelles. Au niveau de l'animal, sont à explorer les compromis entre les fonctions physiologiques de production, de reproduction et d'immunité, le rôle du microbiote ainsi que les mécanismes psycho-neuro-endocriniens qui relient l'état mental et la santé. Au niveau de l'exploitation, il conviendrait de considérer l’expertise des éleveurs et d’évaluer l’effet des changements de pratiques sur leur bien-être au travail. Au niveau de la filière de production comme du territoire, les stratégies pour améliorer la santé et le bien-être des animaux tout en préservant la viabilité économique sont à étudier, comme la possibilité d’étiquetage et de labellisation des produits, le consentement à payer des consommateurs, les conséquences de l'hétérogénéité phénotypique des animaux pour la transformation des produits et la répartition spatiale des exploitations. Au niveau des citoyens, un défi consiste à mieux relier leurs préoccupations en matière de bien-être des animaux et de santé. Ces nombreuses questions plaident en faveur d'une approche interdisciplinaire et transdisciplinaire sur de nombreux sujets, associant l’ensemble des acteurs, y compris les décideurs publics, dans une démarche de recherche participative.
Factors Associated with Unsuccessful Revascularization Surgery in Traumatic Upper-Extremity Amputation
Authors: Pyörny Joonas , Sletten Ida Neergård , Jokihaara Jarkko
Published: December 2024

Background:

Microsurgical emergency revascularization surgery for traumatic upper-extremity amputations demands high resource use. Injury details and patient characteristics influence the decision of whether to revascularize or revise an amputation involving the upper extremity. Our aim was to study associations between those factors and unsuccessful revascularization to provide information for clinical decision-making regarding amputation injuries.

Methods:

We studied all consecutive patients who had undergone an upper-extremity revascularization at Tampere University Hospital between 2009 and 2019. The primary outcome was the technical success or failure of the operation, which was defined as the survival or non-survival of the amputated tissue. Using logistic regression, we analyzed prognostic factors including age, sex, smoking status, diabetes mellitus, injury mechanism (cut, crush, or avulsion), extent of tissue loss before treatment (number of lost joints), and amputation type (total or subtotal).

Results:

A total of 282 patients (mean age, 47 years; 14% female; mostly White Caucasian) were included. The proportion of successful revascularizations (survival of all reconstructed tissue) was 76% (214 of 282). An avulsion injury mechanism (adjusted odds ratio [aOR], 5.9; 95% confidence interval [CI], 2.5 to 14.2), crush injury mechanism (aOR, 2.8; 95% CI, 1.1 to 7.0]), and total amputation type (aOR, 2.9; 95% CI, 1.5 to 5.8) were the prognostic factors that were associated with the highest risk of unsuccessful revascularizations. We found an S-shaped, nonlinear association between patient age and unsuccessful revascularizations and a U-shaped, nonlinear association between the amount of tissue loss before treatment and unsuccessful revascularizations. There was no evidence of an association between unsuccessful revascularizations and patient sex, smoking, or diabetes mellitus.

Conclusions:

Injury details were the most significant prognostic factors of an unsuccessful upper-extremity revascularization, while age was the only patient characteristic that was associated with this outcome. In particular, total amputation type and avulsion and crush injury mechanisms yielded a higher risk of unsuccessful revascularization. We recommend considering this information when making decisions regarding the treatment of upper-extremity amputation injuries.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Non-specific inflammatory markers on remains from Ducové locality Slovakia: A bioarcheological study on sinusitis on all paranasal sinuses from the Late Bronze Age until Modern Age
Authors: Bodoríková Silvia , Dörnhoferová Michaela , Majláthová Lucia
Published: December 2024

Sinusitis is classified among the inflammatory diseases of the paranasal sinuses. Is divided into acute and chronic inflammation. There is not much research on respiratory conditions on bioarcheological material from the whole world, and none has been conducted in Slovakia. This study aims to enrich the data on sinusitis in our region. The sample from the cemetery in Ducové, with 1881 uncovered graves, with 1745 individuals represents the largest dataset from both Slovakia and the Czech Republic. We estimated sex, age categories, and sinusitis prevalence among individuals based on chronological factors. The remains from this burial site are dated to the Late Bronze Age to the Modern Age. The individuals were divided into four sets: the Late Bronze Age (LBA) set, the Great Moravian (GM) set, the Medieval (M) set, and the Modern (MA) set. In all sets, we revealed a high percentage of sinusitis prevalence: 20.00% LBA, 45.00% GM, 38.39% M, and 37.16% MA. The difference in the prevalence of sinusitis between the age groups was probably due to exposure to adverse factors. There were no significant differences between males and females. The study confirmed our hypotheses of an increase in the prevalence of sinusitis with increasing age, but the magnitude of environmental burden or type of environmental burden and the association with social status could not be revealed.
Superior hypoxia tolerance of intertidal triplefin fish is associated with low critical oxygen tension and high phosphorylating capacity in brain mitochondria
Authors: Devaux Jules B.L. , McArley Tristan J. , Herbert Neill , H Anthony J.R.
Published: December 2024

At the terminus of the O2 cascade, mitochondria play an important role in O2 utilisation and energy conservation, with adaptive modifications occasionally shared among hypoxia-tolerant species. Here, we sought to determine whether mitochondrial adaptations in brain tissue explain the hypoxia tolerance of New Zealand triplefin fishes (Tripterygiidae). We compared two intertidal species (Bellapiscis medius and Forsterygion lapillum), both likely adapted to hypoxia-reoxygenation exposures, and two subtidal species (F. varium and F. malcomi), which inhabit normoxic waters. To assess hypoxia tolerance, we determined loss of equilibrium (LOE) during hypoxia exposure and measured the critical O2 tension (Pcrit). Intertidal species displayed superior hypoxia tolerance as assessed by LOE and also had lower Pcrit (LOE versus Pcrit R2 = 0.92). High-resolution respirometry was used to measure mitochondrial respiration in homogenate and permeabilised fragments of brain. While a weak relationship was apparent between mitochondrial O2 binding affinity (mP50) and hypoxia tolerance, maximum phosphorylating O2 flux (OxPhos) and O2 catalytic rates were strongly correlated with hypoxia tolerance. Although cytochrome-c-oxidase activity was highest in the most hypoxia-tolerant species B. medius, it was only weakly correlated with hypoxia tolerance across species. Notably, the high OxPhos capacity of intertidal species was not associated with higher whole animal resting O2 consumption, suggesting intertidal species maintain high capacity for ATP production without incurring increased basal energetic costs. While somewhat paradoxical, the low Pcrit/high OxPhos strategy of intertidal species may provide flexibility in the dynamic intertidal environment where short, severe periods of hypoxia are interspersed with high energy demand environmental conditions (e.g. acute warming).
Heavy metals stabilization in lead zinc mine tailings by using Mechanical, Mechano-chemical and Microwave oven activation; Tailing waste utilization in building materials
Authors: Nawaz Karim , Yu Guangwei , Noman Muhammad , Jintao Fang , Ahmad Wisal
Published: December 2024

Lead zinc mine tailings are hazardous waste that are produces by mining activities. Poor management of tailings waste can lead heavy metals leaching to the ground water or surrounding environment if not properly managed. In this study lead zinc mine tailings were treated by using several activation methods to stabilize the heavy metals in them. Thus, in this study several activation methods like mechanical activation, mechano-chemical activation ad microwave oven activation was applied to stabilize the heavy metals and reuse them effectively in construction Toxicity characteristic leaching procedure were performed to analyze the leaching concentration based on USEPA standard limits. Modified sequential extraction procedure (BCR) was used to determine the detailed distribution of heavy metals. 20% of tailings were replaced with cement. Tailings aggregates used in construction reduces the cost of construction and minimize the emissions of CO2 to the environment as cement consumption reduced. Characterizations supported the stabilized structure of concrete after activation methods applied. Overall, it was concluded that activation methods can treat tailings powders and make them suitable for safe utilization in construction. Mechanical activation (200 rpm), mechano-chemical-activation (Graphene Oxide, 0.03%) and microwave oven activation at high power for 40 minutes was selected for successful applications for concrete based on tailings due to their better stabilizing effects and Cementous properties.
A rare case of FH-deficient renal cell carcinoma with signet ring cells features
Authors: Lu Yin , Hu Chunfang , Jia Jiedong , Liu Ye , Wen Yanlin , Zhang Huijuan , Wang Xiaoliang , Li Haitao , Shen Guihua , Huang Wenting
Published: December 2024

Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a clinically aggressive tumor with high rates of progression and mortality. A wide range of morphological variations has been observed in FH-deficient RCC, initially described as type 2 papillary RCC or unclassified RCC. Here, we report a case of FH-deficient RCC with rare signet ring cells features. The patient was diagnosed with FH-deficient renal cell carcinoma and suspected to have hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome. After 4 months, pulmonary metastasis occurred in the patient. We herein describe the first case of FH-deficient renal tumor with signet ring cells features, which expands the morphological spectrum of this tumor and may suggest a poor prognosis.
Mitigation of adverse effect of cadmium toxicity in lettuce (Lactuca sativa L.) through foliar application of chitosan and spermidine
Authors: Rafique Maham , Noreen Zahra , Usman Sheeraz , Shah Anis Ali , Taj Hafsa , Raja Vaseem , El-Sheikh Mohamed A.
Published: December 2024

Cd stress is considered among the most harmful abiotic stresses because of its toxicity and ability to alter the ultrastructure of plants. Lettuce has a strong ability to collect Cd from the soil but also has a negative effect on its development and nutritional quality. To address this issue, foliar sprays of chitosan and spermidine have been used as feasible remedies because of their reported ability to improve plant tolerance to heavy metals. The effects of Cd and foliar treatment with chitosan, spermidine and their combination on the morphological, physiological, and biochemical attributes of two Lactuca sativa L. varieties were estimated in this study. The experiment was performed in 48 pots with 2 varieties in a four-way completely randomized design (CRD) with 3 replicates. Cd stress was applied by using 0 and 10 ppm CdCl2. The concentrations of exogenous chitosan and spermidine were 200 and 145 ppm, respectively. Both Lactuca sativa varieties presented similar results under Cd stress and presented significant reductions in biomass. Foliar sprays of chitosan and spermidine increased the morphology, photosynthetic features, secondary metabolites, and antioxidant activity; decreased H2O2 and MDA; and improved RMP in both varieties. This work aims to provide useful insights into sustainable techniques for increasing lettuce plant resilience against Cd toxicity by explaining the synergistic effects of chitosan and spermidine.
Optimized Feature Selection and Enhanced Recurrent Neural Network for Financial Fraud Detection
Authors: Chandrashekar Rakesh , Onyema Edeh Michael , Mallik Saurav , Kavin Balasubramanian Prabhu , Archakam Jayasheel Kumar Kalagatoori , Annamalai Deepak Arun , Shah Mohd Asif
Published: December 2024

Financial fraud presents a significant challenge worldwide, impeding the steady growth of financial markets. However, detecting fraud is complicated by an imbalanced dataset, where the number of legitimate transactions fraudulent ones. To address this issue, intelligent financial statement fraud detection solutions have been industrialised to assist stakeholders in making informed decisions. This study proposes a novel approach to fraud detection using a Modified Uni-directional Deep-Recurrent Neural Network (MDRNN) model. The model is augmented by the Artificial Rabbit Optimization Algorithm (AROA) to enhance classification accuracy by selecting relevant features. Additionally, the parameters of the MDRNN model were optimized using the Red Fox Optimization (RFO) model. A comparative analysis between the proposed method and existing approaches was conducted and it proved greater efficiency compared to other techniques. The model accomplished an accuracy of 95.65% and identified 591 fraudulent transactions correctly. The outcome of this study would contribute to the improvement of classification accuracy, reduction of misclassification of credit card transactions, and associated cost, and enhancement of financial transaction security.
Predicting response to patients with gastric cancer via dynamic-aware model with longitudinal liquid biopsy data
Authors: chen zifan , Zhao Jie , Li Yanyan , Li Yilin , Nan Xinyu , Liu Huimin , Feng Xujiao , Dong Bin , Shen Lin , Chen Yang , Zhang Li
Published: December 2024

Gastric cancer (GC) presents challenges in predicting treatment responses due to patient-specific heterogeneity. Recently, liquid biopsies have emerged as a valuable data modality, providing essential cellular and molecular insights and facilitating the capture of time-sensitive information. This study aimed to harness artificial intelligence (AI) technology to analyze longitudinal liquid biopsy data. We collected a dataset from longitudinal liquid biopsies of 91 patients at Peking Cancer Hospital, spanning from July 2019 to April 2022, including 1,895 tumor-related cellular images and 1,698 tumor marker indices. Subsequently, we introduced a Dynamic-Aware Model (DAM) to predict GC treatment responses. DAM incorporates dynamic data through AI components for in-depth longitudinal analysis. Using three-fold cross-validation, DAM exhibited superior performance in predicting treatment responses compared to traditional methods (AUCs: 0.807 vs. 0.582), maintained stable efficacy in the test set (AUC: 0.802), and accurately predicted responses from early treatment data. Moreover, DAM's visual analysis of attention mechanisms identified six key visual features associated strongly with treatment responses. These findings represent a pioneering effort in applying AI technology for interpreting longitudinal liquid biopsy data and employ visual analytics in GC, offering a promising avenue toward precise response prediction and tailored treatment strategies for patients with GC.
Forensic analysis of dead bodies recovered from wells in North Tunisia: Autopsy-based study.
Authors: ZAARA Mohamed Amine , GHARBAOUI Mariem , HMANDI Ons , FTIMA Mohamed Aymen BEN , BELLALI Mohamed , ALLOUCHE Mohamed , KHELIL Mehdi BEN
Published: December 2024

Background: This study aimed to analyze the pattern and post-mortem findings of dead bodies found in wells in Northern Tunisia.
A cross-sectional retrospective study was conducted in northern Tunisia over 15 years (2005-2019). Epidemiological features, well characteristics, autopsy findings, cause of death, and manner of death were analyzed.
Results: Findings showed a male predominance (sex ratio M/F 2.38), with a median age of 37.5 years. The deceased lived primarily in rural areas (61.4%) and 27.8% were daily laborers. A history of mental illness was reported in 36.9% of the cases and a history of suicide attempts in 29 cases (16.5%). The wells were unprotected in most of the cases (91.5%). Bodies were found mainly in wells located near/in the homes of the decedents (50.3%). Putrefaction was observed in 18.2% of the cases and suggestive signs of immersion in 88.1%. The cause of death in our study was mainly drowning (82.4%). The cause of death was concluded as accidental in 58.5%.
Conclusion: Deceased individuals discovered in wells remain a challenge for forensic pathologists. This study contributed to identifying the patterns of the deceased.
Compressive Strength and Isothermal Calorimetry Study of Binary and Ternary Geopolymer Mortars at Early Age
Authors: Pan Zhu , Jiang Zhirui , Sun Xiaokun , Zhang Mo , Cao Yifang
Published: December 2024

The reaction process of geopolymers is closely related to their early-stage setting behaviours and mechanical properties. This paper investigates the early reaction, dissolution, and setting characteristics of composite geopolymer binders that include fly ash, calcium aluminate cement (CAC), and silica fume (SF). The reaction process of the geopolymer binders were analysed by using isothermal calorimetry, inductively coupled plasma optical emission spectrometry (ICP-OES) and scanning electron microscopy (SEM). All starting materials were activated using a combination of NaOH solution and Na2SiO3 solution at a ratio of 1:2.5. In the alkali-activated CAC/SF/fly ash system, the calorimetric curves exhibited only one peak within the first 10 minutes of reaction. In contrast, the alkali-activated CAC/fly ash system showed a second peak at around 9 hours for the mixture containing 20% CAC. A strong linear relationship was found between the cumulative heat value and the compressive strength of all investigated mixes at early ages.
Study of mismatched negativity in patients with unilateral sudden sensorineural hearing loss
Authors: Hu Pingping , Liu Di , Chen Chen , Xu Li , Guan Bing , Zhu Bin
Published: December 2024

Objective
This study was conducted to investigate the functional status of the auditory center in patients with different types of unilateral sudden sensorineural hearing loss (SSNHL).
Methods
All experimental protocols were approved by the Ethics Committee of Northern Jiangsu People’s Hospita,with approval ID 2019107. Our team confirms that all research was performed in accordance with relevant guidelines in accordance with the Declaration of Helsinki. MMN, pure tone audiometry (PTA), and auditory brainstem response (ABR) were performed on patients with different types of unilateral SSNHL and 25 healthy controls. The characteristics of latency and wave amplitude of MMN in each group were observed, and the differences in latency and amplitude of MMN between the four groups and the healthy control group were compared.
Results
All the subjects elicited MMN waveforms, and there was a significant difference in MMN latency between the four groups of SSNHL patients and healthy controls (p < 0.05).
Conclusion
The latency of MMN in patients with different types of unilateral SSNHL is shorter than that in the control group. And researchers hypothesized that the auditory function of the cerebral cortex of patients with unilateral SSNHL has changed, resulting in corresponding changes in their auditory centers and adaptive changes in their function.
Surgical treatment for refractory spontaneous pneumothorax （experience of 16 cases）
Authors: Liang Hailong , Yan Zhaofei , Liu Xuanchen , Yan Tiansheng
Published: December 2024

Background
Recurrence is major existing problem in spontaneous pneumothorax (SP) therapy. Refractory SP refers to recurrent SP post previous VATS or pleurodesis. There is no consensus on how to treat refractory SP so as to avoid another recurrence. We introduce our experiences in reoperation for such refractory SP.
Methods
we retrospectively review 16 consecutive cases of refractory SP who received repeated VATS treatment in Beijing University of Chinese medicine Dongfang Hospital. Perioperative data are documented, and postoperative follow up is made, with emphasis on introducing surgical strategy and special technique established by our team, and discussing how these measures could effectively avoid recurrence.
Results
Among all qualified patients,15 cases had previous VATS history,1 case had previous chemical pleurodesis history. VATS therapy was performed in all cases, and was converted to thoracotomy only in 1 case due to severe thoracic callous-like adhesions. All patients recovered well and were discharged. Mean postoperative follow-up time is 15.2 months. 3 cases of recurrence happened. Among them,2 cases were cured by drainage ,1 case were cured with oxygen inhalation.
Conclusions
Our proposed surgical strategy and techniques may effectively treating refractory SP and prevent further recurrence.
Clinical Application of Customized Total temporomandibular joint prosthesis by 3D printing：A five-year follow-up study
Authors: Xu Qingyu , Huo Liang , Wei Xiang , Han Zixiang , Bu Lingtong , Chen Minjie , Zheng Jisi , Yang Chi
Published: December 2024

Objectives
This study aims to evaluate the clinical efficacy and stability of customized total temporomandibular joint (TMJ) prosthesis by 3D printing from TMJ Yang’s prosthesis system after five-years follow-up.
Materials and Methods
This prospective single-center case series study recruited patients required total TMJ prosthesis replacement from March 2016 to September 2022. Patient information was collected and followed up at 1 month, 3 months, 6 months, 1 year, 2 years and 5 years post-surgery. Using CT and panoramic scans to evaluate the prosthesis’ position and bone integration. Pain, diet and mandibular function were evaluated by VAS score, and maximum interincisal opening, mouth opening deviation and mandibular maximum forward and lateral movement were recorded. SPSS was used for data analysis.
Results
49 consecutive patients with an average age of 52.88 ± 13.78 years were included. The mean follow-up time was 5.00 ± 1.88 years. There were no postoperative infections, and the wound healed well. The occlusion and facial type remained stable, with stable prosthesis and excellent bone integration. After surgery, pain, mandibular function, and diet improved significantly (P < 0.05) and remained stable 1 year later. The maximum interincisal opening increased (P < 0.05), with mouth opening deviation and movement on the diseased side similar to preoperative levels, but movement on the non-diseased side and forward movement decreased slightly.
Conclusions
The customized total TMJ prosthesis by 3D printing from TMJ Yang’s prosthesis system has a good efficacy and stability during five years’ clinical application.
Clinical Relevance:
This study provides a new, safe and effective prosthesis option for temporomandibular joint reconstruction.
Trial registration
Prospective reports on Chinese customized total temporomandibular joint prosthesis reconstruction cases (ChiCTRONC16009712). http//www.chictr.org.cn/showproj.aspx?proj=16091
Association of hospital teaching characteristics with readmission and complication outcomes among patients receiving radiotherapy and brachytherapy for breast cancer: A Nationwide Readmissions Database Analysis
Authors: Zhong Yimei , Liu Bingxin , Zhou Jifang , Ge Yali , Rui Na , Shen Liliang , Yang Fan
Published: December 2024

Background
Radiotherapy and brachytherapy are common treatments for breast cancer, but few studies have examined the impact of hospital characteristics on patient outcomes. This study evaluated the influence of hospital teaching status on prognosis and healthcare resource utilization (HCRU) in breast cancer patients receiving these therapies.
Method
We conducted a retrospective cohort analysis using the US Nationwide Readmissions Database (NRD), including female breast cancer patients aged ≥ 18 years who received brachytherapy or radiotherapy between January 1, 2016, and December 30, 2021. Logistic regression models assessed the association between hospital teaching status and outcomes such as radiation-related complications, in-hospital mortality, and readmission rates.
Results
Of 9,030 patients, 7,177 (79.5%) were treated at teaching hospitals. Teaching hospital patients were younger, had higher rates of metastatic cancer, and were less likely to undergo breast-conserving surgery or mastectomy. In-hospital mortality was higher for radiotherapy than brachytherapy (4.2% vs 0.3%), with no significant difference between hospital types. Radiation-related complications were more frequent in non-teaching hospitals for both radiotherapy (OR: 1.11 [1.01, 1.21]) and brachytherapy (OR: 1.59 [0.97, 2.62]). Radiotherapy readmission rates were lower at non-teaching hospitals at 30 (OR: 0.82 [0.70, 0.95]) and 90 days (OR: 0.84 [0.74, 0.95]), with reduced costs and shorter length of stay.
Conclusion
Significant differences in prognosis and HCRU exist for breast cancer patients undergoing radiotherapy at teaching versus non-teaching hospitals, warranting further investigation.