bluuebunny/crossref_metadata_2025 huggingface dataset:
Lithium Might Hold the Key to our Clean Energy Future, but Will this Star Metal Fully Deliver on its Green Potential?
Authors: QUIJANO Gabriela
Published: May 2020

Salinas Grandes is a vast salt flat in the high-altitude Puna region of Salta and Jujuy, two north-western provinces of Argentina. It is situated in one of the world’s driest regions, with an extremely fragile ecosystem. Salinas Grandes is so iconic and beautiful that Argentinians voted it amongst the country’s top seven natural wonders in May 2019.1 In addition to its beauty, this stunning desert of salt also holds one of the largest reserves of lithium in the world. Lithium is a light and versatile metal used to produce, among other things, the lithium-ion batteries that power electric vehicles (EV). As global efforts to phase out fossil fuels from our transport systems and adopt clean energy alternatives increase, lithium is becoming increasingly critical. It is no wonder, therefore, that industry has coined it the ‘white gold’.2 Salinas Grandes is only one of many salt lakes in North West Argentina which, together with Bolivia and Chile, form what is known as the ‘lithium triangle’. It is estimated that these three countries alone account for more than half of the world’s lithium.3 Global demand for lithium to produce EV is expected to grow rapidly over the coming decade. To meet this demand, the lithium industry will require significant investment to ramp up additional supply.4 As a result, all eyes have turned to the ‘lithium triangle’ and investment in the region has soared in recent years.5 For the three developing countries, this represents a unique opportunity to attract much-needed foreign investment and boost economic growth.6
Constitutional Law and Abortion in Saskatchewan:The Freedom of Informed Choice (Abortions) Act
Authors: Burningham Sarah
Published: May 2020

This paper reviews the history of Bill 53, theFreedom of Informed Choice (Abortions) Act. A private member’s bill introduced in the Saskatchewan Legislative Assembly in 1985, Bill 53 would have imposed additional consent requirements on women seeking abortions. After concerns about its constitutionality were raised, the Bill was referred to the Saskatchewan Court of Appeal, which found it fell outside provincial jurisdiction. This paper explores the connection between Bill 53 and its more well-known cousins, Morgentaler and Borowski, and examines judicial and political decision-making in the early Charter era.
Evaluating the impact of a health hackathon on collaborative team science: a Social Network Analysis (SNA)
Authors: Fattah Layla , Gabrilove Janice , Bradley Fay
Published: May 2020

The Mount Sinai Health Hackathon is designed to provide a novel forum to foster experiential team science training. Utilizing a Social Network Analysis survey, we studied the impact of the Mount Sinai Health Hackathon on the nature of collaborative relationships of hackathon participants. After the event, the number of links between participants from different disciplines increased and network density overall increased, suggesting a more interconnected network with greater interdisciplinary communication. This social network approach may be a useful addition to the evaluation strategies for team science education initiatives.
Epidemiology of Coronavirus Disease 2019 (COVID-19) Caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Authors: Wei Maoti , Yang Ning , Wang Fenghua , Zhao Guoping , Gao Hongwei , Li Yuming
Published: May 2020

In December, 2019, an infectious outbreak of unknown cause occurred in Wuhan, which attracted intense attention. Shortly after the virus was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the epidemic of coronavirus disease 2019 (COVID-19) broke out, and an information storm occurred. At that time, 2 important aspects, that is, the stages of spread and the components of the epidemic, were unclear. Answers to the questions (1) what are the sources, (2) how do infections occur, and (3) who will be affected should be clarified as the outbreak continues to evolve. Furthermore, components of the epidemic and the stages of spread should be explored and discussed. Based on information of SARS, Middle East respiratory syndrome (MERS), and COVID-19, the components of the epidemic (the sources, the routes of infection, and the susceptible population) will be discussed, as well as the role of natural and social factors involved. Epidemiologic characteristics of patients will be traced based on current information.
Are Iranian Sulfur Mustard Gas-Exposed Survivors More Vulnerable to SARS-CoV-2? Some Similarity in Their Pathogenesis
Authors: Farnoosh Gholamreza , Ghanei Mostafa , Khorramdelazad Hossein , Alishiri Gholamhossein , Jalali Farahani Alireza , Shahriary Alireza , Hosseini Zijoud Seyed Reza
Published: May 2020

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged as a health problem worldwide. It seems that COVID-19 is more lethal for Iranian veterans with a history of exposure to mustard gas. There are some similarities in the pathogenesis of SARS-CoV-2 and mustard gas in immune system disruption and pulmonary infection. SARS-CoV-2 and mustard gas inducing oxidative stress, immune system dysregulation, cytokine storm, and overexpression of angiotensin-converting enzyme II (ACE2) receptor in lungs that act as functional entry receptors for SARS-CoV-2. Moreover, Iranian survivors of mustard gas exposure are more susceptible and vulnerable to COVID-19. It is suggested that the principles of COVID-19 infection prevention and control be adhered to more stringently in Iranian survivors of mustard gas exposure than others who have not been exposed to mustard gas. Therefore, in this review, we discuss the different pathologic aspects of lung injury caused by mustard gas and also the relationship between this damage and the increased susceptibility of Iranian mustard gas exposed survivors to COVID-19.
Predicted Effects of Stopping COVID-19 Lockdown on Italian Hospital Demand
Authors: Bollon Jordy , Paganini Matteo , Nava Consuelo Rubina , De Vita Nello , Vaschetto Rosanna , Ragazzoni Luca , Della Corte Francesco , Barone-Adesi Francesco
Published: May 2020

Objectives:

Italy has been one of the first countries to implement mitigation measures to curb the coronavirus disease 2019 (COVID-19) pandemic. There is currently a debate on when and how such measures should be loosened. To forecast the demand for hospital intensive care unit (ICU) and non-ICU beds for COVID-19 patients from May to September, we developed 2 models, assuming a gradual easing of restrictions or an intermittent lockdown.

Methods:

We used a compartmental model to evaluate 2 scenarios: (A) an intermittent lockdown; (B) a gradual relaxation of the lockdown. Predicted ICU and non-ICU demand was compared with the peak in hospital bed use observed in April 2020.

Results:

Under scenario A, while ICU demand will remain below the peak, the number of non-ICU will substantially rise and will exceed it (133%; 95% confidence interval [CI]: 94-171). Under scenario B, a rise in ICU and non-ICU demand will start in July and will progressively increase over the summer 2020, reaching 95% (95% CI: 71-121) and 237% (95% CI: 191-282) of the April peak.

Conclusions:

Italian hospital demand is likely to remain high in the next months. If restrictions are reduced, planning for the next several months should consider an increase in health-care resources to maintain surge capacity across the country.
Micromamíferos recuperados en sitios arqueológicos de precordillera en los Andes del Centro-Occidente Argentino (Holoceno tardío): Aspectos tafonómicos y paleoambientales
Authors: López José Manuel , Chiavazza Horacio
Published: May 2020

Se presentan los resultados del análisis de restos óseos y dentarios de micromamíferos (≤1 kg) recuperados en Vaquería Gruta 2 (VQG2), un sitio arqueológico localizado en el piedemonte alto de la precordillera de Mendoza (Argentina) con dataciones correspondientes al Holoceno tardío. Estos resultados se comparan con aquellos reportados para conjuntos óseos de micromamíferos cordilleranos del Centro-Occidente Argentino. Se realizó un análisis tafonómico para aproximarse a los posibles agentes acumuladores del conjunto óseo, sobre la base de abundancias relativas, patrones de fractura y digestión. Se analizaron variables orientadas a evaluar la actividad antrópica, tales como huellas de corte y termoalteraciones. Los resultados también se compararon con valores reportados en estudios tafonómicos actualísticos regionales para distintos depredadores. El análisis tafonómico permitió determinar que fueron aves rapaces los agentes responsables de la acumulación ósea recuperada en VQG2. Esta misma fue producto, probablemente, de una acumulación mixta. Asimismo, se realizó un análisis de la composición taxonómica de VQG2. Tanto la presencia de especies extirpadas en el registro arqueológico (Reithrodon auritus) como la mayor diversidad y equitatividad en dicho registro, en comparación con los ensambles actuales de micromamíferos, permiten pensar en un escenario de mayor heterogeneidad ambiental durante el Holoceno tardío, con mayor disponibilidad de parches de recursos que en el presente.
Vegetarian, pescatarian and flexitarian diets: sociodemographic determinants and association with cardiovascular risk factors in a Swiss urban population
Authors: Wozniak Hannah , Larpin Christophe , de Mestral Carlos , Guessous Idris , Reny Jean-Luc , Stringhini Silvia
Published: May 2020

Prevalence and trends of different vegetarian diets remain unknown, with estimates varying depending on the source. Evidence suggests that vegetarian diets are associated with a more favourable cardiovascular risk profile. The present study aimed to assess the prevalence and trends of different types of vegetarian diets in a population-based representative sample, sociodemographic characteristics of participants following such diets and the association of these diets with cardiovascular risk factors. Using repeated cross-sectional population-based surveys conducted in Geneva, Switzerland, 10 797 individuals participated in the study between 2005 and 2017. Participants were classified as vegetarians, pescatarians, flexitarians or omnivores using an FFQ. Sociodemographic and cardiovascular risk factors were evaluated through questionnaires, anthropometric measurements and blood tests. Findings show prevalence of vegetarians increased from 0·5 to 1·2 %, pescatarians from 0·3 to 1·1 % and flexitarians remained stable at 15·6 % of the population over the study period. Compared with omnivores, vegetarians were more likely to be young (OR 2·38; 95 % CI 1·01, 5·6), have higher education (OR 1·59; 95 % CI 1·01, 2·49) and lower income (OR 1·83; 95 % CI 1·04, 3·21); pescatarians and flexitarians were more likely to be women (pescatarian: OR 1·81; 95 % CI 1·10, 3·00; vegetarian: OR 1·57; 95 % CI 1·41, 1·75) and flexitarians were also more likely to have a lower income (OR 1·31; 95 % CI 1·13, 1·53). Participants who adhered to any diet excluding/reducing meat intake had lower BMI, total cholesterol and hypertension compared with omnivores. The present study shows an increase in the prevalence of vegetarians over a 13-year period and suggests that the different vegetarian diets assessed are associated with a better cardiovascular risk profile.
Origin of aeolian dust emitted from the Tarim Basin based on the ESR signal intensity and crystallinity index of quartz: the recycling system of fine detrital material within the basin
Authors: Isozaki Yuko , Tada Ryuji , Sun Youbin , Zheng Hongbo , Toyoda Shin , Sugiura Naomi , Karasuda Akinori , Hasegawa Hitoshi
Published: May 2020

The Tarim Basin is the major source of aeolian dust in the northern hemisphere. Glacial activity in the mountains, transportation by rivers and homogenization by wind are believed to be responsible for dust production within the basin. However, the major source(s) and homogenization process(es) are not clear. Moreover, provenance studies on fine fractions have never been conducted. Here, we measured electron spin resonance (ESR) signal intensity and the crystallinity index of quartz in fine (< 16 μm) and coarse (> 64 μm) fractions of river sediments, dry lake sediments and mountain loess to examine the process(es) that produce aeolian dust. The result suggests that the coarse fraction of the river sediment was derived from the bedrock in the drainage area. The ESR signal intensity and crystallinity index of the fine fraction of river sediments from the Tian Shan Mountains and mountainous rivers in the westernmost Kunlun and Pamir mountains are also similar to the coarse fraction, suggesting the same sources. However, the ESR signal intensity and crystallinity index of the fine fraction of river sediments from the Kunlun Mountains are different from the coarse fraction and converge towards values close to the average for the fine fraction of river sediments and mountain loess. Convergence of the ESR and crystallinity index values for the fine fraction of river sediments from the Kunlun Mountains can be explained by contamination of the river sediments by aeolian dust. The convergent values resulted from the homogenization of fine detrital material by repeated recycling within the basin.
Asian dust from land to sea: processes, history and effect from modern observation to geological records
Authors: Wan Shiming , Sun Youbin , Nagashima Kana
Published: May 2020

Production, transport and deposition of aeolian dust from land to sea closely interact with regional environment and global climate. This Special Issue addresses transport of aeolian dust from the Asian inland to the Loess Plateau and North Pacific Ocean and their possible links to oceanic ecosystem, global climate and even human activity, over various timescales. The papers in this volume are multidisciplinary in nature and include sedimentology, mineralogy, geochemistry, environmental magnetism and climate modelling on multi-timescales from interannual, glacial–interglacial to tectonic timescales. Based on modern observation, geological records and modelling, this Special Issue offers new insights especially into aeolian provenance, dynamics controls on dust production, a novel marine aeolian proxy, as well as long-term aeolian input to the marginal basins of NE Asia and its influence on oceanic productivity. This issue provides a good example for future comprehensive studies of source-to-sink processes of Asian dust from land to sea.
Anisotropic potential around charged absorbing small particle in a collisional electronegative plasma with ion drift
Authors: Zobnin Andrey V.
Published: May 2020

A distribution of the electric potentials around a charged absorbing particle in a drifting weakly ionised collisional plasma with negative ions is calculated in the linear hydrodynamic approach. Coulomb-like asymptote of the electric potential around the absorbing particle deforms under the action of the negative ions’ flow and exhibits a valley profile along the flow behind the particle. The presence of the flowing negative ions can be conducive to string formation in the dust structures at relatively large pressures.
A network analysis of post-traumatic stress and psychosis symptoms
Authors: Hardy Amy , O'Driscoll Ciaran , Steel Craig , van der Gaag Mark , van den Berg David
Published: May 2020

Background

Understanding the interplay between trauma-related psychological mechanisms and psychotic symptoms may improve the effectiveness of interventions for post-traumatic stress reactions in psychosis. Network theory assumes that mental health problems persist not because of a common latent variable, but from dynamic feedback loops between symptoms, thereby addressing the heterogeneous and overlapping nature of traumagenic and psychotic diagnoses. This is a proof-of-concept study examining interactions between post-traumatic stress symptoms, which were hypothesized to reflect trauma-related psychological mechanisms, and auditory hallucinations and delusions.

Method

Baseline data from two randomised controlled trials (N = 216) of trauma-focused therapy in people with post-traumatic stress symptoms (87.5% met diagnostic criteria for PTSD) and psychotic disorder were analysed. Reexperiencing, hyperarousal, avoidance, trauma-related beliefs, auditory hallucinations and delusional beliefs were used to estimate a Gaussian graphical model along with expected node influence and predictability (proportion of explained variance).

Results

Trauma-related beliefs had the largest direct influence on the network and, together with hypervigilance, were implicated in the shortest paths from flashbacks to delusions and auditory hallucinations.

Conclusions

These findings are in contrast to previous research suggesting a central role for re-experiencing, emotional numbing and interpersonal avoidance in psychosis. Trauma-related beliefs were the psychological mechanism most associated with psychotic symptoms, although not all relevant mechanisms were measured. This work demonstrates that investigating multiple putative mediators may clarify which processes are most relevant to trauma-related psychosis. Further research should use network modelling to investigate how the spectrum of traumatic stress reactions play a role in psychotic symptoms.
Cost-effectiveness evaluation for pricing medicines and devices: A new value-based price adjustment system in Japan
Authors: Shiroiwa Takeru
Published: May 2020

Objectives

In Japan, a new cost-effectiveness evaluation system for medicine and medical device pricing was employed in April 2019 after a trial implementation. This study describes the discussions held from April 2016 to March 2019 concerning the newly introduced system.

Methods

Using published government documents, discussions with stakeholders, and the minutes of the Chuikyo committee meetings, the following issues are addressed: (i) the results of the trial implementation and (ii) an overview of the newly introduced system.

Results

During the trial implementation, thirteen products were evaluated and their prices adjusted. The process of the new system—which was to be implemented in FY 2019—takes about 15–18 months to complete after listing of the target products by the National Health Insurance. The target products are selected principally based on sales volume, degree of innovation (premium), and disclosure of rationale for price setting. First, a manufacturer submits the cost-effectiveness data, which is then reviewed by the Center for Outcomes Research and Economic Evaluation for Health (C2H) in collaboration with academics. The results of the cost-effectiveness evaluation are not considered during the decision-making process concerning the product's listing. The price adjustment system is similar to value-based pricing (VBP); hence, the new system can be considered as VBP adjustment.

Conclusion

Cost-effectiveness evaluation can help promote both technological innovation and sustainability of the healthcare system. We need to create a greater capacity for enhancing this academic review system.
Assistive Device Use among Community-Dwelling Older Adults: A Profile of Canadians Using Hearing, Vision, and Mobility Devices in the Canadian Longitudinal Study on Aging
Authors: Ishigami Yoko , Jutai Jeffrey , Kirkland Susan
Published: May 2020

There is increasing recognition that using assistive devices can support healthy aging. Minimizing discomfort and loss of function and increasing independence can have a substantial impact physically, psychologically, and financially on persons with functional impairments and resulting activity limitations, as well as on caregivers and communities. However, it remains unclear who uses assistive devices and how device use can influence social participation. The current analysis used CLSA baseline data from 51,338 older adults between the ages of 45 and 85. Measures of socio-demographic, health, and social characteristics were analyzed by sex and age groups. Weighted cross-tabulations were used to report correlations between independent variables and assistive device use for hearing, vision, and mobility. We found that assistive device use was higher among those who were of older age, had less education, were widowed, had lower income, and had poorer health. Assistive devices were used differently according to sex and social participation, providing insight into assistive device use for the well-being of older adults and their families.
On-farm risk factors associated withLeptospirashedding in New Zealand dairy cattle
Authors: Yupiana Y. , Vallée E. , Wilson P. , Weston J. F. , Benschop J. , Collins-Emerson J. , Heuer C.
Published: May 2020

This study aimed to evaluate risk factors associated with shedding of pathogenicLeptospiraspecies in urine at animal and herd levels. In total, 200 dairy farms were randomly selected from the DairyNZ database. Urine samples were taken from 20 lactating, clinically normal cows in each herd between January and April 2016 and tested by real-time polymerase chain reaction (PCR) usinggyrBas the target gene. Overall, 26.5% of 200 farms had at least one PCR positive cow and 2.4% of 4000 cows were sheddingLeptospirain the urine. Using a questionnaire, information about risk factors at cow and farm level was collected via face-to-face interviews with farm owners and managers. Animals on all but one farm had been vaccinated against Hardjo and Pomona and cows on 54 of 200 (27%) farms had also been vaccinated against Copenhageni in at least one age group (calves, heifers and cows). Associations found to be statistically significant in univariate analysis (atP< 0.2) were assessed by multivariable logistic regression. Factors associated with shedding included cattle age (Odds ratio (OR) 0.82, 95% CI 0.71–0.95), keeping sheep (OR 5.57, 95% confidence interval (CI) 1.46–21.25) or dogs (OR 1.45, 95% CI 1.07–1.97) and managing milking cows in a single as opposed to multiple groups (OR 0.45, 95% CI 0.20–0.99). We conclude that younger cattle were more likely to be sheddingLeptospirathan older cattle and that the presence of sheep and dogs was associated with an increased risk of shedding in cows. Larger herds were at higher risk of havingLeptospirashedders. However, none of the environmental risk factors that were assessed (e.g. access to standing water, drinking-water source), or wildlife abundance on-farm, or pasture were associated with shedding, possibly due to low statistical power, given the low overall shedding rate.
What is the reliability of visually based animal trade census outcomes? A case study involving the market monitoring of the Sumatran Laughingthrush Garrulax bicolor
Authors: BUŠINA TOMÁŠ , KOUBA MAREK , PASARIBU NURSAHARA
Published: May 2020

A considerable variety of Indonesian avifauna is forced into the domestic and international pet trade, where the majority of individuals are caught in the wild. To monitor the volume and development of the trade and to evaluate the threat status of the traded species, bird market surveys are usually performed. The most commonly used monitoring technique is the “Direct Counting Method – DCM”, i.e. the counting of openly displayed individuals offered for sale. In this study, we evaluate the reliability of the outputs that DCM delivers by conducting regular long-term bird censuses at two of the main animal markets in Medan (Sumatra, Indonesia) involving 10 major local vendors specialising in the Sumatran Laughingthrush (Garrulax bicolor; SL), our target species. Both markets were visited from March to December 2015 with three different survey intervals (one, two and four visits per month). In total, according to DCM, we recorded up to 461 SL individuals offered for sale. However, a comparison of the monthly logs recorded directly by the vendors during the same period revealed that DCM only uncovered a negligible proportion of the total trade. Specifically, we detected only 4.6%, 8.1% and 16.1% of the traded SL individuals in relation to the set survey intervals. While the numbers of recorded SL individuals according to DCM and the three survey intervals were significantly interrelated, none of them correlated with the real numbers of traded birds provided by the vendors. Our results suggest that census-based market data are underestimated, and represent an unknown proportion of true trade volumes, regardless of the intensity of visits. In order to obtain reliable data and prevent the underestimation of the volume of trade, we recommend of undisclosed monitoring of markets and the engagement of trusted individuals with a past personal interest in this field or, if possible, the vendors themselves.
Efficacy of low-dose ketamine infusion in anxious vs nonanxious depression: revisiting the Adjunctive Ketamine Study of Taiwanese Patients with Treatment-Resistant Depression
Authors: Chen Mu-Hong , Lin Wei-Chen , Wu Hui-Ju , Bai Ya-Mei , Li Cheng-Ta , Tsai Shih-Jen , Hong Chen-Jee , Tu Pei-Chi , Cheng Chih-Ming , Su Tung-Ping
Published: May 2020

Background

The antidepressant effect of low-dose ketamine infusion on Taiwanese patients with anxious vs nonanxious treatment-resistant depression (ANX-TRD vs NANX-TRD) has remained unknown.

Methods

In total, 71 patients with TRD were randomized to three groups. Each group had participants who received saline infusions mixed with 0 (a normal saline infusion), 0.2, and 0.5 mg/kg of ketamine. Participants were followed up for 2 weeks. Anxious depression was defined as major depressive disorder with a total score of 7 or more on the 17-item Hamilton Depression Rating Scale Anxiety-Somatization factor. Generalized estimating equation models were used to investigate the effects of treatment (ketamine vs placebo) and depression type (ANX-TRD vs NANX-TRD) in the reduction of depressive symptoms during the follow-up period.

Results

Patients with ANX-TRD were less likely to respond to a single low-dose ketamine infusion than those with NANX-TRD. Among patients with NANX-TRD, low-dose ketamine infusion was significantly superior to placebo for reducing depressive symptoms. However, among patients with ANX-TRD, ketamine was not superior to placebo; nonetheless, approximately 30% of the patients responded to ketamine infusion compared to 13% who responded to the placebo.

Conclusions

Low-dose ketamine infusion was effective for Taiwanese patients with NANX-TRD but not so effective for those with ANX-TRD. A higher level of anxiety severity accompanying depression was related to greater depression severity. This may confound and reduce the antidepressant effect of ketamine infusion.
Physical Diagnosis of the 2016 Great Barrier Reef Bleaching Event
Authors: Karnauskas Kristopher B.
Published: May 2020

Widespread coral bleaching across the Great Barrier Reef (GBR) in 2016 is often reportedly caused by El Niño and/or global warming. However, the GBR is not in a region where it is straightforward to anticipate sea surface temperature (SST) warming during El Niño, and the role of climate change is unclear. This study uses a diverse range of observations to investigate the physical causes of SST anomalies that developed on the GBR in 2016. Warm SST anomalies developed in two stages. Initial warming was caused by El Niño shifting the global‐scale pattern of convection, increasing solar radiation in the Coral Sea. The warm anomaly was extended and amplified near the coast by a terrestrial heat wave propagating across eastern Australia, further warming the GBR through turbulent heat flux. It is concluded that El Niño caused the SST anomaly, and global warming increased its amplitude and extended it by several months.
Meteoroid Impacts as a Source of Bennu's Particle Ejection Events
Authors: Bottke W. F. , Moorhead A. V. , Connolly H. C. , Hergenrother C. W. , Molaro J. L. , Michel P. , Nolan M. C. , Schwartz S. R. , Vokrouhlický D. , Walsh K. J. , Lauretta D. S.
Published: May 2020

Asteroid (101955) Bennu, a near‐Earth object with a primitive carbonaceous chondrite‐like composition, was observed by the Origins, Spectral Interpretation, Resource Identification, and Security‐Regolith Explorer (OSIRIS‐REx) spacecraft to undergo multiple particle ejection events near perihelion between December 2018 and February 2019. The three largest events observed during this period, which all occurred 3.5 to 6 hr after local noon, placed numerous particles <10 cm on temporary orbits around Bennu. Here we examine whether these events could have been produced by sporadic meteoroid impacts using the National Aeronautics and Space Administration's (NASA) Meteoroid Engineering Model 3.0. Most projectiles that impact Bennu come from nearly isotropic or Jupiter‐family comets and have evolved toward the Sun by Poynting‐Robertson drag. We find that 7,000‐J impacts on Bennu occur with a biweekly cadence near perihelion, with a preference to strike in the late afternoon (~6 pm local time). This timing matches observations. Crater scaling laws also indicate that these impact energies can reproduce the sizes and masses of the largest observed particles, provided the surface has the cohesive properties of weak, porous materials. Bennu's ejection events could be caused by the same kinds of meteoroid impacts that created the Moon's asymmetric debris cloud observed by the Lunar Atmosphere and Dust Environment Explorer (LADEE). Our findings also suggest that fewer ejection events should take place as Bennu moves further away from the Sun, a result that can be tested with future observations.
Juno Waves Detection of Dust Impacts Near Jupiter
Authors: Ye S.‐Y. , Averkamp T. F. , Kurth W. S. , Brennan M. , Bolton S. , Connerney J. E. P. , Joergensen J. L.
Published: May 2020

The Juno spacecraft entered orbit at Jupiter on 5 July 2016. Since then, Juno has orbited Jupiter in high inclination orbits, crossing the ring plane near perijove. During 20 of the first 21 crossings, the Waves instrument detected signals associated with dust impacts. The impact rate profiles show peaks of order 6 s−1 around the ring plane with half width at half maximum ~2,000–3,000 km. The polarity ratio of the impact signals did not follow the areas of the antennas exposed to dust impacts that change due to the rotation of the spacecraft, suggesting Waves detects impacts on the Juno spacecraft and not just on the Waves antennas. The impact rate profile changed during Perijove 19, when the spacecraft rotation axis was tilted to the south, increasing the area of the solar panels exposed to impacts, indicating that the detected impacts were on the spacecraft body. Grain sizes of order 1 μm are estimated, and the differential size distribution has a slope of −5.1 and with number densities of order 3 × 10−6 m−3.
Impact of Roughness Length on WRF Simulated Land‐Atmosphere Interactions Over a Hyper‐Arid Region
Authors: Nelli Narendra Reddy , Temimi Marouane , Fonseca Ricardo Morais , Weston Michael John , Thota Mohana Satyanarayana , Valappil Vineeth Krishnan , Branch Oliver , Wulfmeyer Volker , Wehbe Youssef , Al Hosary Taha , Shalaby Abdeltawab , Al Shamsi Noor , Al Naqbi Hajer
Published: May 2020

The aerodynamic roughness length is a crucial parameter that controls surface variables including the horizontal wind, surface temperature, and heat fluxes. Despite its importance, in the Weather Research and Forecasting (WRF) model, this parameter is typically assigned a predefined value, mostly based on the dominant land‐use type. In this work, the roughness length is first estimated from eddy‐covariance measurements at Al Ain in the United Arab Emirates (UAE), a hyper‐arid region, and then ingested into WRF. The estimated roughness length is in the range 1.3–2.2 mm, one order smaller than the default value used in WRF. In line with previous studies, and from WRF model simulations during the warm and cold seasons, it is concluded that, when the roughness length is decreased by an order of magnitude, the horizontal wind speed increases by up to 1 m s−1, the surface temperature rises by up to 2.5°C, and the sensible heat flux decreases by as much as 10 W m−2. In comparison with in situ station and eddy covariance data, and when forced with the updated roughness length, WRF gives more accurate 2‐m air temperature and sensible heat flux predictions. For prevailing wind speeds >6 m s−1, the model underestimates the strength of the near‐surface wind, a tendency that can be partially corrected, typically by 1–3 m s−1, when the updated roughness length is considered. For low wind speeds (<4 m s−1), however, WRF generally overestimates the strength of the wind.
Electrical Resistivity Measurements of Fe‐Si With Implications for the Early Lunar Dynamo
Authors: Berrada Meryem , Secco Richard A. , Yong Wenjun , Littleton Joshua A. H.
Published: May 2020

The effect of impurities on the electrical resistivity of Fe at core conditions is controversial due to the challenges of measuring transport properties of Fe alloys under high‐pressure and high‐temperature conditions. In this study we describe an innovative technique to make wires of Fe‐Si samples initially in powder form for measuring electrical resistivity. The electrical resistivity of Fe‐2, Fe‐8.5, and Fe‐17 wt%Si was measured at 3, 4, and 5 GPa at temperatures into the liquid state and compared to results of Fe‐4.5 wt%Si and Fe from prior studies. Isothermal electrical resistivity increases linearly with increasing Si content. Yet the effect of Si content on the magnitude of the electrical resistivity compared to that of Fe diminished as temperature increased at all experimental pressures. This implies the contribution to the electrical resistivity due to Si impurities is dependent on temperature, in disagreement with Matthiessen's rule. Thermal conductivity of Fe‐Si alloys calculated using the Wiedemann‐Franz law indicates a nonnegligible influence of the Si content on the thermal conductive properties of Fe‐Si alloys. The results are used to calculate the adiabatic heat flux of an Fe‐Si lunar core and date the end of the high magnetic field intensity era of the lunar dynamo to be in the range 3.32–3.80 Ga.
The relevance of transdiagnostic shared networks to the severity of symptoms and cognitive deficits in schizophrenia: a multimodal brain imaging fusion study
Authors: Qi Shile , Bustillo Juan , Turner Jessica A. , Jiang Rongtao , Zhi Dongmei , Fu Zening , Deramus Thomas P. , Vergara Victor , Ma Xiaohong , Yang Xiao , Stevens Mike , Zhuo Chuanjun , Xu Yong , Calhoun Vince D. , Sui Jing
Published: May 2020

Schizophrenia (SZ) is frequently concurrent with substance use, depressive symptoms, social communication and attention deficits. However, the relationship between common brain networks (e.g., SZ vs. substance use, SZ vs. depression, SZ vs. developmental disorders) with SZ on specific symptoms and cognition is unclear. Symptom scores were used as a reference to guide fMRI-sMRI fusion for SZ (n = 94), substance use with drinking (n = 313), smoking (n = 104), major depressive disorder (MDD, n = 260), developmental disorders with autism spectrum disorder (ASD, n = 421) and attention-deficit/hyperactivity disorder (ADHD, n = 244) respectively. Common brain regions were determined by overlapping the symptom-related components between SZ and these other groups. Correlation between the identified common brain regions and cognition/symptoms in an independent SZ dataset (n = 144) was also performed. Results show that (1): substance use was related with cognitive deficits in schizophrenia through gray matter volume (GMV) in anterior cingulate cortex and thalamus; (2) depression was linked to PANSS negative dimensions and reasoning in SZ through a network involving caudate-thalamus-middle/inferior temporal gyrus in GMV; (3) developmental disorders pattern was correlated with poor attention, speed of processing and reasoning in SZ through inferior temporal gyrus in GMV. This study reveals symptom driven transdiagnostic shared networks between SZ and other mental disorders via multi-group data mining, indicating that some potential common underlying brain networks associated with schizophrenia differently with respect to symptoms and cognition. These results have heuristic value and advocate specific approaches to refine available treatment strategies for comorbid conditions in schizophrenia.
Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment
Authors: Sun Bo , Hyun Hyesun , Li Lian-tao , Wang Andrew Z
Published: May 2020

Cancer immunotherapy has received extensive attention due to its ability to activate the innate or adaptive immune systems of patients to combat tumors. Despite a few clinical successes, further endeavors are still needed to tackle unresolved issues, including limited response rates, development of resistance, and immune-related toxicities. Accumulating evidence has pinpointed the tumor microenvironment (TME) as one of the major obstacles in cancer immunotherapy due to its detrimental impacts on tumor-infiltrating immune cells. Nanomedicine has been battling with the TME in the past several decades, and the experience obtained could be exploited to improve current paradigms of immunotherapy. Here, we discuss the metabolic features of the TME and its influence on different types of immune cells. The recent progress in nanoenabled cancer immunotherapy has been summarized with a highlight on the modulation of immune cells, tumor stroma, cytokines and enzymes to reverse the immunosuppressive TME.
Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC
Authors: Rong Chao , Muller Marie F. , Xiang Fang , Jensen Alexandra , Weichert Wilko , Major Gerald , Plinkert Peter K. , Hess Jochen , Affolter Annette
Published: May 2020

Background

Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and conducted in silico prognostic evaluation of the EGFR-MAPK axis in HNSCC.

Methods

Expression of ERK1/2 phosphorylation (pERK1/2) was determined in HNSCC cell lines, which were treated with cetuximab or fractionated-IR. Furthermore, the effect of fractionated IR on pERK1/2 was confirmed in an ex vivo HNSCC tissue culture model. Expression and prognostic significance of EGFR-ERK axis was evaluated in a cohort of radiotherapy plus cetuximab-treated HNSCC. Correlations among EGFR-MAPK signalling components and association between transcript and protein expression profiles and patient survival in HNSCC were analysed using publicly available databases.

Results

ERK1/2 phosphorylation was rebounded by prolonged cetuximab administration and was induced by fractionated IR, which could be suppressed by a MEK inhibitor as a radiosensitiser. In silico assessments suggested that EGFR-MAPK cascade genes and proteins could predict HNSCC patients’ survival as a prognostic signature.

Conclusions

Activation of ERK1/2 signalling contributes to the cellular defence of HNSCC against cetuximab and fractionated IR treatment. EGFR-MAPK axis has a prognostic significance in HNSCC.
Interfering with retrotransposition by two types of CRISPR effectors: Cas12a and Cas13a
Authors: Zhang Niubing , Jing Xinyun , Liu Yuanhua , Chen Minjie , Zhu Xianfeng , Jiang Jing , Wang Hongbing , Li Xuan , Hao Pei
Published: May 2020

CRISPRs are a promising tool being explored in combating exogenous retroviral pathogens and in disabling endogenous retroviruses for organ transplantation. The Cas12a and Cas13a systems offer novel mechanisms of CRISPR actions that have not been evaluated for retrovirus interference. Particularly, a latest study revealed that the activated Cas13a provided bacterial hosts with a “passive protection” mechanism to defend against DNA phage infection by inducing cell growth arrest in infected cells, which is especially significant as it endows Cas13a, a RNA-targeting CRISPR effector, with mount defense against both RNA and DNA invaders. Here, by refitting long terminal repeat retrotransposon Tf1 as a model system, which shares common features with retrovirus regarding their replication mechanism and life cycle, we repurposed CRISPR-Cas12a and -Cas13a to interfere with Tf1 retrotransposition, and evaluated their different mechanisms of action. Cas12a exhibited strong inhibition on retrotransposition, allowing marginal Tf1 transposition that was likely the result of a lasting pool of Tf1 RNA/cDNA intermediates protected within virus-like particles. The residual activities, however, were completely eliminated with new constructs for persistent crRNA targeting. On the other hand, targeting Cas13a to Tf1 RNA intermediates significantly inhibited Tf1 retrotransposition. However, unlike in bacterial hosts, the sustained activation of Cas13a by Tf1 transcripts did not cause cell growth arrest in S. pombe, indicating that virus-activated Cas13a likely acted differently in eukaryotic cells. The study gained insight into the actions of novel CRISPR mechanisms in combating retroviral pathogens, and established system parameters for developing new strategies in treatment of retrovirus-related diseases.
Extinction of eastern Sahul megafauna coincides with sustained environmental deterioration
Authors: Hocknull Scott A. , Lewis Richard , Arnold Lee J. , Pietsch Tim , Joannes-Boyau Renaud , Price Gilbert J. , Moss Patrick , Wood Rachel , Dosseto Anthony , Louys Julien , Olley Jon , Lawrence Rochelle A.
Published: May 2020

Explanations for the Upper Pleistocene extinction of megafauna from Sahul (Australia and New Guinea) remain unresolved. Extinction hypotheses have advanced climate or human-driven scenarios, in spite of over three quarters of Sahul lacking reliable biogeographic or chronologic data. Here we present new megafauna from north-eastern Australia that suffered extinction sometime after 40,100 (±1700) years ago. Megafauna fossils preserved alongside leaves, seeds, pollen and insects, indicate a sclerophyllous forest with heathy understorey that was home to aquatic and terrestrial carnivorous reptiles and megaherbivores, including the world’s largest kangaroo. Megafauna species diversity is greater compared to southern sites of similar age, which is contrary to expectations if extinctions followed proposed migration routes for people across Sahul. Our results do not support rapid or synchronous human-mediated continental-wide extinction, or the proposed timing of peak extinction events. Instead, megafauna extinctions coincide with regionally staggered spatio-temporal deterioration in hydroclimate coupled with sustained environmental change.
Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
Authors: Srifa Waracharee , Kosaric Nina , Amorin Alvaro , Jadi Othmane , Park Yujin , Mantri Sruthi , Camarena Joab , Gurtner Geoffrey C. , Porteus Matthew
Published: May 2020

Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integration of up to more than 3 kilobases of exogenous DNA in the genome of hMSCs derived from the bone marrow, adipose tissue, and umbilical cord blood without altering their ex vivo characteristics. We generate safe harbor-integrated lines of engineered hMSCs and show that engineered luciferase-expressing hMSCs are transiently active in vivo in wound beds of db/db mice. Moreover, we generate PDGF-BB- and VEGFA-hypersecreting hMSC lines as short-term, local wound healing agents with superior therapeutic efficacy over wildtype hMSCs in the diabetic mouse model without replacing resident cells long-term. This study establishes a precise genetic engineering platform for genetic studies of hMSCs and development of engineered hMSC-based therapies.
Representing the function and sensitivity of coastal interfaces in Earth system models
Authors: Ward Nicholas D. , Megonigal J. Patrick , Bond-Lamberty Ben , Bailey Vanessa L. , Butman David , Canuel Elizabeth A. , Diefenderfer Heida , Ganju Neil K. , Goñi Miguel A. , Graham Emily B. , Hopkinson Charles S. , Khangaonkar Tarang , Langley J. Adam , McDowell Nate G. , Myers-Pigg Allison N. , Neumann Rebecca B. , Osburn Christopher L. , Price René M. , Rowland Joel , Sengupta Aditi , Simard Marc , Thornton Peter E. , Tzortziou Maria , Vargas Rodrigo , Weisenhorn Pamela B. , Windham-Myers Lisamarie
Published: May 2020

Between the land and ocean, diverse coastal ecosystems transform, store, and transport material. Across these interfaces, the dynamic exchange of energy and matter is driven by hydrological and hydrodynamic processes such as river and groundwater discharge, tides, waves, and storms. These dynamics regulate ecosystem functions and Earth’s climate, yet global models lack representation of coastal processes and related feedbacks, impeding their predictions of coastal and global responses to change. Here, we assess existing coastal monitoring networks and regional models, existing challenges in these efforts, and recommend a path towards development of global models that more robustly reflect the coastal interface.
Nature of power electronics and integration of power conversion with communication for talkative power
Authors: He Xiangning , Wang Ruichi , Wu Jiande , Li Wuhua
Published: May 2020

Power electronics and communication electronics are both based on electromagnetic theory, but they are usually regarded as two distinct subfields in electrical engineering. In fact, however, electric power is the most common matter-based carrier of messages; thus, power electronics and communications can be jointly considered. Here we study the essential nature of dc-dc power converters and characterize the similarity of their operation principle to that of communication systems. Based on this similarity and the double modulation methods used in power electronics and communication, a double modulation strategy for both power and data is presented and applied in dc-dc power converters to achieve what we call ‘talkative power’. A modulation strategy called frequency hopping-differential phase shift keying (FH-DPSK) is also presented to overcome the crosstalk between chosen transmission systems. The proposed talkative power strategy sheds new light on and provides inspiration for the further development of power electronics and communication.
Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
Authors: Johnson Elizabeth L. , Heaver Stacey L. , Waters Jillian L. , Kim Benjamin I. , Bretin Alexis , Goodman Andrew L. , Gewirtz Andrew T. , Worgall Tilla S. , Ley Ruth E.
Published: May 2020

Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the development of a range of metabolic disorders from insulin resistance (IR) to hepatic steatosis. SLs are obtained from the diet and generated by de novo synthesis in mammalian tissues. Another potential, but unexplored, source of mammalian SLs is production by Bacteroidetes, the dominant phylum of the gut microbiome. Genomes of Bacteroides spp. and their relatives encode serine palmitoyltransfease (SPT), allowing them to produce SLs. Here, we explore the contribution of SL-production by gut Bacteroides to host SL homeostasis. In human cell culture, bacterial SLs are processed by host SL-metabolic pathways. In mouse models, Bacteroides-derived lipids transfer to host epithelial tissue and the hepatic portal vein. Administration of B. thetaiotaomicron to mice, but not an SPT-deficient strain, reduces de novo SL production and increases liver ceramides. These results indicate that gut-derived bacterial SLs affect host lipid metabolism.