bluuebunny/crossref_metadata_2025 huggingface dataset:
Shaping the future of creative education: the transformative power of VR in art and design learning
Authors: Serna-Mendiburu Gabriela Mariah , Guerra-Tamez Cristobal Rodolfo
Published: April 2024

Addressing a critical gap in the understanding of virtual reality (VR) in education, this study develops and validates a predictive model to elucidate the influence of usability and spatial ability on learning satisfaction among art and design undergraduates. Utilizing structural equation modeling on data from 105 art and design students in Mexico, we demonstrate that enhanced usability and spatial ability in VR significantly predicts increased learning satisfaction, which in turn, positively affects motivation, cognitive benefits, reflective thinking, and perceived learning. Our findings reveal a direct correlation between VR environment design and educational outcomes, suggesting that meticulous attention to usability and spatial navigation can substantially elevate the learning experience in art and design students. This research contributes to educational technology by offering empirical evidence on optimizing VR for higher education, with implications for curriculum design and pedagogical strategies in creative disciplines.
Recent advances in the crosstalk between the brain-derived neurotrophic factor and glucocorticoids
Authors: Tsimpolis Alexandros , Kalafatakis Konstantinos , Charalampopoulos Ioannis
Published: April 2024

Brain-derived neurotrophic factor (BDNF), a key neurotrophin within the brain, by selectively activating the TrkB receptor, exerts multimodal effects on neurodevelopment, synaptic plasticity, cellular integrity and neural network dynamics. In parallel, glucocorticoids (GCs), vital steroid hormones, which are secreted by adrenal glands and rapidly diffused across the mammalian body (including the brain), activate two different groups of intracellular receptors, the mineralocorticoid and the glucocorticoid receptors, modulating a wide range of genomic, epigenomic and postgenomic events, also expressed in the neural tissue and implicated in neurodevelopment, synaptic plasticity, cellular homeostasis, cognitive and emotional processing. Recent research evidences indicate that these two major regulatory systems interact at various levels: they share common intracellular downstream pathways, GCs differentially regulate BDNF expression, under certain conditions BDNF antagonises the GC-induced effects on long-term potentiation, neuritic outgrowth and cellular death, while GCs regulate the intraneuronal transportation and the lysosomal degradation of BDNF. Currently, the BDNF-GC crosstalk features have been mainly studied in neurons, although initial findings show that this crosstalk could be equally important for other brain cell types, such as astrocytes. Elucidating the precise neurobiological significance of BDNF-GC interactions in a tempospatial manner, is crucial for understanding the subtleties of brain function and dysfunction, with implications for neurodegenerative and neuroinflammatory diseases, mood disorders and cognitive enhancement strategies.
Metabolic and inflammatory parameters in relation to baseline characterization and treatment outcome in patients with prolactinoma: insights from a retrospective cohort study at a single tertiary center
Authors: Hofbauer Susanna , Horka Laura , Seidenberg Samuel , Da Mutten Raffaele , Regli Luca , Serra Carlo , Beuschlein Felix , Erlic Zoran
Published: April 2024

Background

Prolactinomas (PRLs) are prevalent pituitary adenomas associated with metabolic changes and increased cardiovascular morbidity. This study examined clinical, endocrine, metabolic, and inflammatory profiles in PRL patients, aiming to identify potential prognostic markers.

Methods

The study comprised data from 59 PRL patients gathered in a registry at the University Hospital of Zurich. Diagnostic criteria included MRI findings and elevated serum prolactin levels. We assessed baseline and follow-up clinical demographics, metabolic markers, serum inflammation-based scores, and endocrine parameters. Treatment outcomes were evaluated based on prolactin normalization, tumor shrinkage, and cabergoline dosage.

Results

The PRL cohort exhibited a higher prevalence of overweight/obesity, prediabetes/diabetes mellitus, and dyslipidemia compared to the general population. Significant correlations were found between PRL characteristics and BMI, HbA1c, and fT4 levels. Follow-up data indicated decreases in tumor size, tumor volume, prolactin levels, and LDL-cholesterol, alongside increases in fT4 and sex hormones levels. No significant associations were observed between baseline parameters and tumor shrinkage at follow-up. A positive association was noted between PRL size/volume and the time to achieve prolactin normalization, and a negative association with baseline fT4 levels.

Conclusion

This study underscores the metabolic significance of PRL, with notable correlations between PRL parameters and metabolic indices. However, inflammatory markers were not significantly correlated with patient stratification or outcome prediction. These findings highlight the necessity for standardized follow-up protocols and further research into the metabolic pathogenesis in PRL patients.
Damage creep model of viscoelastic rock based on fractional derivative and experimental verification
Authors: Zhou Xin , Ju Nengpan , Cai Junchao , He Chaoyang , Wang Jue , Wang Hao , Liu Ruiting
Published: April 2024

Exploring the creep law of sandstone provides a theoretical basis for evaluating the long-term stability of geotechnical engineering projects in red beds. Based on a conventional triaxial test of sandstone, a progressive loading triaxial creep test is conducted. The deformation characteristics and laws of each sample in different deformation stages are summarized, and the laws relating steady creep rate, stress and time are analyzed. On this basis, a nonlinear viscoelastic‒plastic creep model based on fractional derivative theory and damage theory is established. According to the nonlinear fitting results, the parameter sensitivities are analyzed. The results verify the rationality of the model; this model has a good fitting effect for each creep deformation stage, especially for the accelerated creep stage. The constitutive relationship of the model is simple, clear and easily applicable. The research results provide a reference for studying the long-term stability of geotechnical engineering projects.
Spatial-temporal evolution of plateau and plain lakes and climate driving factors based on Google Earth Engine platform
Authors: Guo Qiaozhen , Yang Guang , Wu Xiaoxu , Jin Huiyi , Tian Yaxin
Published: April 2024

Accurate understanding of lake water dynamic changes is beneficial to sustainable utilization of water resources and maintenance of ecological balance. Lake change is sensitively reflective of climate and environment change. This study chooses plateau lake and plain lake as the study area, and uses Landsat TM/ETM+/OLI and meteorological data as data source. Based on the Google Earth Engine platform, lake areas are extracted using NDWI method, and lake morphological characteristics are analyzed. The model between climate factors and lake area is established and analyzed in sections according to the difference of lake change trend. The results indicate that the morphological characteristic index of the plateau lakes changes little, but that of the plain lakes changes greatly. Precipitation in the plain lakes fluctuates more violently than that in the plateau lakes. The temperature fluctuation in the plateau lakes is larger than that in the plain lakes.
First study using a fixed-wing drone for systematic measurements of aerosol vertical distribution close to a civil airport
Authors: Harm-Altstädter Barbara , Voß Anna , Aust Sebastian , Bärfuss Konrad , Bretschneider Lutz , Merkel Maik , Pätzold Falk , Schlerf Andreas , Weinhold Kay , Wiedensohler Alfred , Winkler Ulf , Lampert Astrid
Published: April 2024

A profound knowledge of pollutant emissions and transport processes is essential to better assess the impact on local air quality, which ultimately affects human health. This is of special importance in the proximity of airports, as flight activities are a major source of ultrafine aerosol particles (UFP) that are associated with adverse health effects. A quantification of the aerosol population in the horizontal and in particular in the vertical distribution has not been sufficiently characterized so far, but is of crucial relevance, as the atmospheric boundary layer (ABL) is strongly interacting with aerosols. For this purpose, the fixed-wing research drone called ALADINA (Application of Light-weight Aircraft for Detecting in-situ Aerosol) was operated at a distance of approximately 4 km downwind of the German airport Berlin Brandenburg (BER) on October 11–19, 2021. During the investigation period, 140 vertical profiles of different meteorological parameters and aerosol particle sizes were obtained on six measurement days between the surface and up to a maximum altitude of 750 m above ground level (a.g.l.). The investigations indicate several features: The stability of the ABL is a key characteristic for the vertical distribution of aerosol population with highest concentrations close to ground. Inversion layers further enhance horizontal transport so that airport pollutants can be moved to a further distance away. The airborne observations of total particle number concentration (TNC) coincide with ground-based data from fix-point sites. They show a high variability depending on the distance to the plume as well as upwind position and highest concentrations of TNC related to rush hours of airport operations.
Pathways to enhance the efficiency of forestry ecological conservation and restoration: empirical evidence from Heilongjiang Province, China
Authors: Ren Yue , Arif Muhammad , Cao Yukun , Zhang Shaopeng
Published: April 2024

This paper proposes a theoretical framework for assessing ecological protection and restoration from the perspective of ecological efficiency. We applied the super-efficiency Slack-based measure model to examine the social and economic impacts of ecological resource consumption transformation in Heilongjiang Province, China. Additionally, a convergence analysis was used to evaluate and test the impact of the standard deviation ellipse method on regional sustainability. The results indicated that the land use structure was unstable; the conversion rate of resource consumption was low; and the average Ecological efficiency was only 0.343 in terms of the land use structure. Funds for forest ecological restoration have a significant impact on the effectiveness of ecological resource transformation. Implementing the Chinese ecological restoration project improves the ecological efficiency level of the communities. The center of gravity of ecological efficiency moved greatly in the years when forestry investment increased. Technological transfer and diffusion, experience imitation in environmental regulation, and eventually convergent steady-state levels of the ecological efficiency of different regions are necessary to improve the economic and social development level of regions with low environmental quality efforts should be made to reduce resource consumption intensity, increase fund utilization efficiency, and form a comprehensive and systematic system of ecological environment governance through reasonable enhancement of regional environmental regulations, increased investment in technological advancement, and funds for ecological protection and restoration.
The oyster revolution: shell middens, shell temper, and settling down in North America’s Chesapeake region
Authors: Jenkins Jessica A. , Gallivan Martin D.
Published: April 2024

Transformative social change occurred in the Chesapeake region with the intensification of oyster harvesting and the establishment of central places in estuarine settings at the outset of the Middle Woodland period (ca. A.D. 200). Accompanying the pivot toward estuarine living was the spread of shell-tempered ceramics indexing regional social networks from the Delaware Bay to the mouth of the Chesapeake Bay. Survey and excavation data from the Naval Weapons Station Yorktown (NWSY) on the York River trace this process on Virginia’s lower York River. Here, Middle Woodland populations established central places around the lower embayed portions of tidal creeks. Communal shell middens anchoring these central places offer evidence of intensive oyster harvesting and a history of periodic overharvesting, adjustment, and long-term sustainability. We hypothesize that common pool resource management, i.e., collective action and stewardship in the management of the oyster fishery, was an important part of Native societies’ settling down in this region.
Efficacy and safety of neoadjuvant immunotherapy plus chemotherapy followed by adjuvant immunotherapy in resectable non-small cell lung cancer: a meta-analysis of phase 3 clinical trials
Authors: Zhang Wenjing , Liang Zhanpeng , Zhao Yurong , Li Yanwei , Chen Ting , Li Wenxia , Chen Yunqi , Wu Peiye , Zhang Huatang , Fang Cantu , Li Luzhen
Published: April 2024

Objective

At present, several important trials have been published show that perioperative immunotherapy combined with chemotherapy can improve the prognosis of patients with resectable non-small cell lung cancer, which further optimizes treatment options. Therefore, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety of perioperative immunotherapy combined with chemotherapy in resectable non-small cell lung cancer.

Methods

The following databases were searched for relevant studies: PubMed, EMBASE, Cochrane library (updated 12 October 2023). All randomized trials comparing perioperative immunotherapy combined with chemotherapy versus chemotherapy alone in resectable non-small cell lung cancer were eligible for inclusion. Data were analyzed using Review Manager 5.4.1 (Cochrane collaboration software). Primary outcomes and measures included overall survival (OS), event-free survival (EFS), pathological complete response (pCR), major pathological response (MPR), R0 resection rate, rate of underwent surgery and adverse events (AEs).

Results

A total of 2912 patients (1453 receiving perioperative immunotherapy plus chemotherapy and 1459 receiving chemotherapy alone) were included in this systematic review and meta-analysis. The result showed that compared with chemotherapy alone, combined therapy significantly improved OS (HR = 0.68;95% CI: 0.56-0.83), EFS (HR = 0.58;95% CI: 0.51-0.65), pCR (OR = 7.53;95% CI: 4.63-12.26), MPR (OR = 5.03;95% CI: 3.40-7.44), R0 resection (OR = 1.58;95% CI: 1.152.18) and rate of underwent surgery (OR = 1.25;95% CI: 1.04-1.49). However, combination therapy was associated with higher risk of severe adverse event (OR = 1.46;95% CI: 1.19-1.78; P=0.0002), grade 3 and higher treatment-related adverse event (TRAE) (OR = 1.25;95% CI: 1.06-1.49; P=0.010), TRAE that led to interruption (OR = 1.90;95% CI: 1.34-2.68; P=0.0003) and immune-related adverse event (OR = 2.78;95% CI: 2.18-3.55; P<0.00001). Significant benefits were observed across most subgroups of EFS and pCR. However, no statistical differences were observed for EFS of never smoked (HR = 0.73;95% CI: 0.51-1.05) and EGFR-mutation positive (HR = 0.35;95% CI: 0.04-3.03).

Conclusion

This systematic review and meta-analysis found superior efficacy associated with perioperative immunotherapy plus chemotherapy compared with chemotherapy alone in both tumor regression and prolonged survival in resectable NSCLC, but increased the risk of TRAE, so monitoring for adverse events is warranted.

Systematic review registration

https://www.crd.york.ac.uk/prospero, identifier (CRD42023476786).
Utilizing noncatalytic ACE2 protein mutant as a competitive inhibitor to treat SARS-CoV-2 infection
Authors: Liu Shengjiang , Chen Haifeng , Chen Xiangqun , Luo Ningguang , Peraramelli Sameera , Gong Xiaoming , Zhang Mingwei John , Ou Li
Published: April 2024

Introduction

Angiotensin converting-enzyme 2 (ACE2) is an enzyme catalyzing the conversion of angiotensin 2 into angiotensin 1-7. ACE2 also serves as the receptor of several coronaviruses, including SARS-CoV-1 and SARS-CoV-2. Therefore, ACE2 could be utilized as a therapeutic target for treating these coronaviruses, ideally lacking enzymatic function.

Methods

Based on structural analysis, specific mutations were introduced to generate mutants of ACE2 and ACE2-Fc (fusion protein of ACE2 and Fc region of IgG1). The enzyme activity, binding affinity, and neutralization abilities were measured.

Results and discussion

As predicted, five mutants (AMI081, AMI082, AMI083, AMI084, AMI090) have completely depleted ACE2 enzymatic activities. More importantly, enzyme-linked receptor-ligand assay (ELRLA) and surface plasmon resonance (SPR) results showed that 2 mutants (AMI082, AMI090) maintained binding activity to the viral spike proteins of SARS-CoV-1 and SARS-CoV-2. In An in vitro neutralization experiment using a pseudovirus, SARS-CoV-2 S1 spike protein-packed lentivirus particles, was also performed, showing that AMI082 and AMI090 significantly reduced GFP transgene expression. Further, in vitro virulent neutralization assays using SARS-CoV-2 (strain name: USA-WA1/2020) showed that AMI082 and AMI090 had remarkable inhibitory effects, indicated by comparable IC50 to wildtype ACE2 (5.33 µg/mL). In addition to the direct administration of mutant proteins, an alternative strategy for treating COVID-19 is through AAV delivery to achieve long-lasting effects. Therefore, AAV5 encoding AMI082 and AMI090 were packaged and transgene expression was assessed. In summary, these ACE2 mutants represent a novel approach to prevent or treat COVID-19 and other viruses with the same spike protein.
Case report: A rare immune-related adverse effect: hepatic cavernous hemangioma induced by camrelizumab
Authors: Zhang Chuantao , Wang Guanqun , Liu Ning , Li Tianjun , Zhu Jingjuan , Hou Helei
Published: April 2024

Background

Camrelizumab, a programmed death 1 (PD-1) inhibiting antibody, has demonstrated efficacy in various malignancies and received approval in multiple countries. Despite its therapeutic benefits, camrelizumab is associated with a unique spectrum of immune-related adverse effects (irAEs), predominantly reactive cutaneous capillary endothelial proliferation (RCCEP). However, visceral manifestations of such endothelial proliferations, particularly hepatic cavernous hemangiomas, have not been extensively documented.

Methods

This case series retrospectively reviews six patients who developed hepatic hemangiomas following treatment with camrelizumab in combination with other chemotherapeutic agents. The series highlights the clinical course, imaging findings, management strategies, and outcomes associated with this complication. A detailed analysis was conducted to discern the potential causal relationship between camrelizumab therapy and the development of hepatic hemangiomas.

Results

All six patients, after varying cycles of camrelizumab-based therapy, presented with hepatic lesions identified as cavernous hemangiomas on imaging. These findings were atypical for metastatic disease and were further complicated by significant clinical events, including massive intra-abdominal bleeding post-biopsy. Discontinuation of camrelizumab led to a reduction in the size of the hemangiomas in two cases, suggesting a potential link between the drug and the development of these vascular lesions. The incidence of RCCEP remained high, and the use of other agents such as bevacizumab did not mitigate the occurrence of hepatic hemangiomas, indicating a possible unique pathogenic mechanism associated with camrelizumab.

Conclusion

Hepatic cavernous hemangioma may represent a rare but clinically significant irAE associated with camrelizumab therapy. This series underscores the importance of vigilant monitoring and a high index of suspicion for atypical hepatic lesions in patients undergoing treatment with PD-1 inhibitors. Further studies are warranted to elucidate the pathophysiology of this complication and to establish guidelines for the management and surveillance of patients receiving camrelizumab.
Coupling use of stable isotopes and functional genes as indicators for the impacts of artificial restoration on the carbon storage of a coastal wetland invaded by Spartina alterniflora, southeastern China
Authors: Chu Tianshu , Li Danyang , Shih Yi-Jia , Guo Yuqing , Liu Kai , Ji Fenfen , Li Jun , Yin Yuzhu , Chen Ruohai
Published: April 2024

Coastal wetlands are characterized by high production and thus play an important role in global climate change. In past decades, the invasion of Spartina alterniflora has caused many problems of coastal wetlands in southeastern China, and the restoration of such areas was mainly conducted by replacing Spartina alterniflora with mangrove plants. This may impact the carbon storage dynamics in such areas. In this study, stable isotopes (δ13C and δ15N) and molecular analysis were used to reveal the impact of artificial restoration on the carbon storage of Quanzhou Bay Estuary Wetland Natural Reserve. The major results are as follows: (1) the change in dominant plants results in a changing major source of soil organic matter, from external sources to mangrove plants; (2) the decrease in soil organic matter following the removal of Spartina alterniflora may be primarily caused by the loss of external organic matter, while the production of mangroves may offset such loss and enhance the content and stability of carbon storage over the long term; (3) microbial CO2 assimilation may serve as an alternative source of bioavailable carbon and thus support the activity of benthic community. Our results revealed the long-term benefits of such restoration on the carbon storage function of wetlands invaded by Spartina alterniflora. Furthermore, the integrating of isotopic tracers and molecular technology may provide new insights in understanding the response of the carbon storage in coastal areas to human activity.
Genetic structure of ten Artemia populations from China: cumulative effects of ancient geological events, climatic changes, and human activities
Authors: Li Ke , Zhang Rui , Sui Li-Ying , Zhang Chi , Han Xue-Kai
Published: April 2024

This study investigated the population genetics and distribution patterns of Artemia populations from ten inland salt lakes in China. A total of 1,274,698 Artemia single nucleotide polymorphisms (SNPs) were identified. The results showed that these populations could be geographically and genetically divided into four distinct groups, and that the Tibetan populations were further divided into two subpopulations with a trend of decreasing genetic diversity from west to east. The Tibetan population had the highest genetic diversity, whereas the Shanxi population had the lowest. There was moderate genetic differentiation between the Tibetan populations and greater genetic differentiation between the Xinjiang and Shanxi populations. IBD (isolation by distance) suggested that geographical isolation contributes to genetic differentiation. In addition, there was some degree of gene flow among the ten populations, with A. sinica showing unidirectional gene flow in all populations in the eastern Nagri region. Species distribution modeling showed that mean annual temperature, temperature seasonality, and annual precipitation were the main environmental factors affecting the distribution of Artemia populations and suitable habitats for Tibetan populations will be further reduced in the future. It is necessary to strengthen the protection of germplasm resources and formulate scientific protocols for the sustainable development and utilization of Artemia resources.
Irritable Bowel Syndrome in medical students at a Peruvian university: a cross-sectional study
Authors: Quiroga-Castañeda Pedro P. , Berrios-Villegas Iván , Valladares-Garrido Danai , Vera-Ponce Víctor J. , Zila-Velasque J. Pierre , Pereira-Victorio César Johan , Valladares-Garrido Mario J.
Published: April 2024

Background

Irritable Bowel Syndrome has emerged as a significant public health challenge, particularly relevant in medical students due to the high demands of their studies, academic stress, and susceptibility to eating disorders. Nevertheless, conclusive evidence regarding the factors associated with Irritable Bowel Syndrome in the Latin American student population remains limited. The objective of this study was to determine the prevalence and factors associated with Irritable Bowel Syndrome in Human Medicine students at a university in northern Peru.

Methods

A cross-sectional analytical study conducted in Lambayeque, northern Peru. With 403 Human Medicine students (66.5% female, 33.5% male). A simple random probabilistic sampling type was used, based on a list of students enrolled. A multivariate analysis was conducted to determine the factors associated using simple and multiple regression models. Generalized Linear Models were applied, using the Poisson distribution family, robust variance, and the academic year as a cluster.

Results

The prevalence of Irritable Bowel Syndrome was 16.9% (95% CI: 13.37–20.86). The median age was 21 years, with 66.5% being female. In the multiple regression analysis, Irritable Bowel Syndrome was associated with a higher prevalence of depression (PR: 3.63; 95% CI: 1.26–10.49) and eating disorders (PR: 1.57; 95% CI: 1.01–2.43). For each additional year of age, the prevalence of Irritable Bowel Syndrome decreased by 9% (PR: 0.91; 95% CI: 0.83–0.99).

Conclusion

This study reveals that approximately two out of every 10 students exhibit symptoms related to IBS, underscoring its significance in the Human Medicine student population. Furthermore, depression and eating disorders were identified as significant factors associated with IBS in students. Consequently, it is essential to focus efforts on early identification and the implementation of preventive measures to mitigate the development of this pathology, given its substantial prevalence in this context of Human Medicine students.
Evaluation of the in vitro susceptibility of clinical isolates of NDM-producing Klebsiella pneumoniae to new antibiotics included in a treatment regimen for infections
Authors: Słabisz Natalia , Leśnik Patrycja , Janc Jarosław , Fidut Miłosz , Bartoszewicz Marzenna , Dudek-Wicher Ruth , Nawrot Urszula
Published: April 2024

Background

Due to the growing resistance to routinely used antibiotics, the search for new antibiotics or their combinations with effective inhibitors against multidrug-resistant microorganisms is ongoing. In our study, we assessed the in vitro drug susceptibility of Klebsiella pneumoniae strains producing New Delhi metallo-β-lactamases (NDM) to antibiotics included in the Infectious Diseases Society of America (IDSA) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) recommendations.

Methods

A total of 60 strains of NDM-producing K. pneumoniae were obtained from different patients hospitalized at the 4th Military Hospital in Wroclaw between 2019 and 2022 and subjected to drug susceptibility to selected antibiotics, including the effects of drug combinations.

Results

Among the tested antibiotics, the highest sensitivity (100%) was observed for cefiderocol, eravacycline (interpreted according to the European Committee on Antimicrobial Susceptibility Testing [EUCAST]), and tigecycline. Sensitivity to intravenous fosfomycin varied depending on the method used. Using the “strip stacking” method, determining cumulative sensitivity to ceftazidime/avibactam and aztreonam demonstrated 100% in vitro sensitivity to this combination among the tested strains.

Conclusion

The in vitro susceptibility assessment demonstrated that, the best therapeutic option for treating infections caused by carbapenemase-producing strains seems to be a combination of ceftazidime/avibactam with aztreonam. Due to the safety of using both drugs, cost effectiveness, and the broadest indications for use among the tested antibiotics, this therapy should be the first-line treatment for carbapenemase-producing Enterobacterales infections. Nevertheless, a comprehensive evaluation of the efficacy of treating infections caused by NDM-producing K. pneumoniae strains should include not only in vitro susceptibility assessment but also an analysis of clinical cases.
Bibliometric analysis and visualization of quorum sensing research over the last two decade
Authors: Chen Xinghan , Li Jiaqi , Liao Ruohan , Shi Xiujun , Xing Yan , Xu Xuewen , Xiao Haitao , Xiao Dongqin
Published: April 2024

Background

Quorum sensing (QS) research stands as a pivotal and multifaceted domain within microbiology, holding profound implications across various scientific disciplines. This bibliometric analysis seeks to offer an extensive overview of QS research, covering the period from 2004 to 2023. It aims to elucidate the hotspots, trends, and the evolving dynamics within this research domain.

Methods

We conducted an exhaustive review of the literature, employing meticulous data curation from the Science Citation Index Extension (SCI-E) within the Web of Science (WOS) database. Subsequently, our survey delves into evolving publication trends, the constellation of influential authors and institutions, key journals shaping the discourse, global collaborative networks, and thematic hotspots that define the QS research field.

Results

The findings demonstrate a consistent and growing interest in QS research throughout the years, encompassing a substantial dataset of 4,849 analyzed articles. Journals such as Frontiers in Microbiology have emerged as significant contributor to the QS literature, highlighting the increasing recognition of QS's importance across various research fields. Influential research in the realm of QS often centers on microbial communication, biofilm formation, and the development of QS inhibitors. Notably, leading countries engaged in QS research include the United States, China, and India. Moreover, the analysis identifies research focal points spanning diverse domains, including pharmacological properties, genetics and metabolic pathways, as well as physiological and signal transduction mechanisms, reaffirming the multidisciplinary character of QS research.

Conclusion

This bibliometric exploration provides a panoramic overview of the current state of QS research. The data portrays a consistent trend of expansion and advancement within this domain, signaling numerous prospects for forthcoming research and development. Scholars and stakeholders engaged in the QS field can harness these findings to navigate the evolving terrain with precision and speed, thereby enhancing our comprehension and utilization of QS in various scientific and clinical domains.
Machine learning based on the EEG and structural MRI can predict different stages of vascular cognitive impairment
Authors: Li Zihao , Wu Meini , Yin Changhao , Wang Zhenqi , Wang Jianhang , Chen Lingyu , Zhao Weina
Published: April 2024

Background

Vascular cognitive impairment (VCI) is a major cause of cognitive impairment in the elderly and a co-factor in the development and progression of most neurodegenerative diseases. With the continuing development of neuroimaging, multiple markers can be combined to provide richer biological information, but little is known about their diagnostic value in VCI.

Methods

A total of 83 subjects participated in our study, including 32 patients with vascular cognitive impairment with no dementia (VCIND), 21 patients with vascular dementia (VD), and 30 normal controls (NC). We utilized resting-state quantitative electroencephalography (qEEG) power spectra, structural magnetic resonance imaging (sMRI) for feature screening, and combined them with support vector machines to predict VCI patients at different disease stages.

Results

The classification performance of sMRI outperformed qEEG when distinguishing VD from NC (AUC of 0.90 vs. 0,82), and sMRI also outperformed qEEG when distinguishing VD from VCIND (AUC of 0.8 vs. 0,0.64), but both underperformed when distinguishing VCIND from NC (AUC of 0.58 vs. 0.56). In contrast, the joint model based on qEEG and sMRI features showed relatively good classification accuracy (AUC of 0.72) to discriminate VCIND from NC, higher than that of either qEEG or sMRI alone.

Conclusion

Patients at varying stages of VCI exhibit diverse levels of brain structure and neurophysiological abnormalities. EEG serves as an affordable and convenient diagnostic means to differentiate between different VCI stages. A machine learning model that utilizes EEG and sMRI as composite markers is highly valuable in distinguishing diverse VCI stages and in individually tailoring the diagnosis.
Micro-and mesoscale aspects of neurodegeneration in engineered human neural networks carrying the LRRK2 G2019S mutation
Authors: Valderhaug Vibeke Devold , Ramstad Ola Huse , van de Wijdeven Rosanne , Heiney Kristine , Nichele Stefano , Sandvig Axel , Sandvig Ioanna
Published: April 2024

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been widely linked to Parkinson’s disease, where the G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. LRRK2-related mutations have been extensively studied, yet the wide variety of cellular and network events related to these mutations remain poorly understood. The advancement and availability of tools for neural engineering now enable modeling of selected pathological aspects of neurodegenerative disease in human neural networks in vitro. Our study revealed distinct pathology associated dynamics in engineered human cortical neural networks carrying the LRRK2 G2019S mutation compared to healthy isogenic control neural networks. The neurons carrying the LRRK2 G2019S mutation self-organized into networks with aberrant morphology and mitochondrial dynamics, affecting emerging structure–function relationships both at the micro-and mesoscale. Taken together, the findings of our study points toward an overall heightened metabolic demand in networks carrying the LRRK2 G2019S mutation, as well as a resilience to change in response to perturbation, compared to healthy isogenic controls.
Baseline perihematomal edema, C-reactive protein, and 30-day mortality are not associated in intracerebral hemorrhage
Authors: Sobowale Oluwaseun A. , Hostettler Isabel C. , Wu Teddy Y. , Heal Calvin , Wilson Duncan , Shah Darshan G. , Strbian Daniel , Putaala Jukka , Tatlisumak Turgut , Vail Andy , Sharma Gagan , Davis Stephen M. , Werring David J. , Meretoja Atte , Allan Stuart M. , Parry-Jones Adrian R.
Published: April 2024

Background

The relationship between baseline perihematomal edema (PHE) and inflammation, and their impact on survival after intracerebral hemorrhage (ICH) are not well understood.

Objective

Assess the association between baseline PHE, baseline C-reactive protein (CRP), and early death after ICH.

Methods

Analysis of pooled data from multicenter ICH registries. We included patients presenting within 24 h of symptom onset, using multifactorial linear regression model to assess the association between CRP and edema extension distance (EED), and a multifactorial Cox regression model to assess the association between CRP, PHE volume and 30-day mortality.

Results

We included 1,034 patients. Median age was 69 (interquartile range [IQR] 59–79), median baseline ICH volume 11.5 (IQR 4.3–28.9) mL, and median baseline CRP 2.5 (IQR 1.5–7.0) mg/L. In the multifactorial analysis [adjusting for cohort, age, sex, log-ICH volume, ICH location, intraventricular hemorrhage (IVH), statin use, glucose, and systolic blood pressure], baseline log-CRP was not associated with baseline EED: for a 50% increase in CRP the difference in expected mean EED was 0.004 cm (95%CI 0.000–0.008, p = 0.055). In a further multifactorial analysis, after adjusting for key predictors of mortality, neither a 50% increase in PHE volume nor CRP were associated with higher 30-day mortality (HR 0.97; 95%CI 0.90–1.05, p = 0.51 and HR 0.98; 95%CI 0.93–1.03, p = 0.41, respectively).

Conclusion

Higher baseline CRP is not associated with higher baseline edema, which is also not associated with mortality. Edema at baseline might be driven by different pathophysiological processes with different effects on outcome.
Aging as a target for the prevention and treatment of Alzheimer’s disease
Authors: Yap Lauren E. , Hunt James E. , Turner Raymond Scott
Published: April 2024

Alzheimer’s disease (AD), the most common etiology of dementia in older adults, is projected to double in prevalence over the next few decades. Current treatments for AD manage symptoms or slow progressive decline, but are accompanied by significant inconvenience, risk, and cost. Thus, a better understanding of the risk factors and pathophysiology of AD is needed to develop novel prevention and treatment strategies. Aging is the most important risk factor for AD. Elucidating molecular mechanisms of aging may suggest novel therapeutic targets. While aging is inevitable, it may be accelerated by caloric excess and slowed by caloric restriction (CR) or intermittent fasting. As such, CR may slow aging and reduce the risk of all diseases of aging, including dementia due to AD. The literature on CR, intermittent fasting, and treatment with polyphenols such as resveratrol—a pharmacologic CR-mimetic—supports this hypothesis based on clinical outcomes as well as biomarkers of aging and AD. More studies exploring the role of CR in regulating aging and AD progression in man are needed to fill gaps in our understanding and develop safer and more effective strategies for the prevention and treatment of AD.
Integrating technology into a successful apomorphine delivery program in Thailand: a 10-year journey of achievements with a five-motto concept
Authors: Phokaewvarangkul Onanong , Kantachadvanich Nithinan , Buranasrikul Vijittra , Sanyawut Kanyawat , Phumphid Saisamorn , Anan Chanawat , Bhidayasiri Roongroj
Published: April 2024

Introduction

Apomorphine, a potent dopamine agonist, is a therapeutic option for patients with Parkinson’s disease and motor fluctuations. However, the adoption of and adherence to this therapy have been limited by the need for complex delivery devices and specialized care as well as resource consumption, posing challenges for new physicians. Thailand is a unique example of a developing nation that has successfully implemented and continued the use of this therapy by employing cooperative technology that has dramatically enhanced apomorphine delivery services.

Methods

Establishing apomorphine delivery services requires significant resources and step-by-step solutions. We began our services by implementing various strategies in three chronological stages: the initial stage (2013–2015), intermediate stage (2016–2019), and current stage (2020–present), each presenting unique challenges. Together, we also implemented a proposed set of five mottos to strengthen our apomorphine delivery service. Using additive technology, we developed a patient registry platform that combined electronic data acquisition, video and remote monitoring using wearable sensors, and in-house mobile applications to support our service.

Results

At the initial stage, we assembled a team to enhance the efficacy and confirm the safety of apomorphine treatment in our hospital. At the intermediate stage, we expanded our apomorphine delivery services beyond just the patients at our hospital. We supported other hospitals in Thailand in setting up their own apomorphine services by educating both physicians and nurses regarding apomorphine therapy. With this educational undertaking, increased apomorphine-related knowledge among medical professionals, and a greater number of hospitals providing apomorphine services, an increasing number of patients were administered apomorphine in subsequent years. Currently, we are providing effective apomorphine delivery to improve patient outcomes and are seamlessly integrating technology into clinical practice. Incorporating integrative technologies in our apomorphine delivery program yielded positive results in data collection and support throughout patient care, in tracking patients’ statuses, in the long-term use of this treatment, and in increasing medication adherence rates.

Conclusion

This perspective paper describes how technology can help provide supportive healthcare services in resource-constrained environments, such as in Thailand, offering a step-by-step approach to overcoming several limitations. The valuable insights from our 10-year journey in successfully integrating technology into apomorphine delivery services can benefit new physicians seeking to replicate our success.
A hidden pathophysiology of endolymphatic hydrops: case report of a patient with spontaneous intracranial hypotension presenting with sudden sensorineural hearing loss with vertigo
Authors: Kim Jong Kwan , Lee Ho Yun , Kim Ha Youn , Kwak Min Young
Published: April 2024

Spontaneous intracranial hypotension (SIH) is characterized by decreased cerebrospinal fluid (CSF) volume due to leakage through the dural membrane. We present the case of a patient with SIH manifested by fluctuating low-frequency hearing loss, tinnitus, and vertigo. In this patient, endolymphatic hydrops in the cochlea and saccule were visualized by means of a special sequence of inner ear magnetic resonance imaging scans, with a gadolinium-based contrast agent administered intravenously. Endolymphatic hydrops is a potential underlying pathophysiology of SIH-associated hearing impairment. We hypothesize that SIH may be a rare cause of endolymphatic hydrops.
Inconclusive results of slow cortical potential neurofeedback for the treatment of chronic post-stroke attention deficits
Authors: Kleih Sonja C. , Botrel Loic
Published: April 2024

Introduction

Individuals who have suffered a stroke may experience long-lasting cognitive impairments that can worsen if left untreated. We investigated whether voluntary control of slow cortical potentials (SCP) through neurofeedback would help alleviate chronic post-stroke symptoms of impaired attention.

Methods

The study initially enrolled twenty-eight participants, but due to a high drop-out rate, only sixteen participants completed eight SCP neurofeedback training sessions within three to four weeks. During these sessions, we gave feedback to the participants on their ability to regulate SCPs on a computer screen.

Results

Our findings showed a non-significant increase in SCP regulation towards cortical negativity. On the behavioral level, we found improved test values in the divided attention and attentional flexibility subtests of the test battery for attention performance. However, we cannot eliminate the possibility that nonspecific effects influenced or caused our results. We have not observed any improvement regarding the effects of attention deficits on participants’ daily lives. We identified five individuals who could gain SCP control successfully and consistently towards negativity. In this group of responders, we observed an improvement in the test results related to divided attention but no other attention-related improvements.

Discussion

Based on our observations, results of SCP neurofeedback training for the treatment of attention deficits after a stroke are inconclusive. More research is necessary to determine the effectiveness of SCP neurofeedback in helping stroke survivors cope with attention-related challenges in their daily lives.
Decoding kinematic information from beta-band motor rhythms of speech motor cortex: a methodological/analytic approach using concurrent speech movement tracking and magnetoencephalography
Authors: Anastasopoulou Ioanna , Cheyne Douglas Owen , van Lieshout Pascal , Johnson Blake Warren
Published: April 2024

Introduction

Articulography and functional neuroimaging are two major tools for studying the neurobiology of speech production. Until now, however, it has generally not been feasible to use both in the same experimental setup because of technical incompatibilities between the two methodologies.

Methods

Here we describe results from a novel articulography system dubbed Magneto-articulography for the Assessment of Speech Kinematics (MASK), which is technically compatible with magnetoencephalography (MEG) brain scanning systems. In the present paper we describe our methodological and analytic approach for extracting brain motor activities related to key kinematic and coordination event parameters derived from time-registered MASK tracking measurements. Data were collected from 10 healthy adults with tracking coils on the tongue, lips, and jaw. Analyses targeted the gestural landmarks of reiterated utterances/ipa/ and /api/, produced at normal and faster rates.

Results

The results show that (1) Speech sensorimotor cortex can be reliably located in peri-rolandic regions of the left hemisphere; (2) mu (8–12 Hz) and beta band (13–30 Hz) neuromotor oscillations are present in the speech signals and contain information structures that are independent of those present in higher-frequency bands; and (3) hypotheses concerning the information content of speech motor rhythms can be systematically evaluated with multivariate pattern analytic techniques.

Discussion

These results show that MASK provides the capability, for deriving subject-specific articulatory parameters, based on well-established and robust motor control parameters, in the same experimental setup as the MEG brain recordings and in temporal and spatial co-register with the brain data. The analytic approach described here provides new capabilities for testing hypotheses concerning the types of kinematic information that are encoded and processed within specific components of the speech neuromotor system.
Effect of calorie restriction and intermittent fasting on glucose homeostasis, lipid profile, inflammatory, and hormonal markers in patients with polycystic ovary syndrome: a systematic review
Authors: Kalsekar Anam S. , Abdelrahim Dana N. , Faris MoezAlIslam E.
Published: April 2024

Background and objective

Polycystic ovary syndrome (PCOS) is a complex hormonal disorder that leads to ovarian cysts, irregular ovulation, and hormonal swings in women. It is a complex and heterogeneous condition that affects 4 to 20% of women of reproductive age worldwide and relates to reproductive, metabolic, and psychosocial dysfunction. Dietary and lifestyle modifications have been proposed to play a central role in the management of PCOS. This study aimed to provide a comprehensive systemic overview of the existing literature on the effects of intermittent fasting (IF) and calorie restriction (CR) regimens on disease markers of PCOS.

Designs and methods

Several databases, such as CINAHL, Cochrane, EBSCOhost, EMBASE, Google Scholar, ProQuest Medical, PubMed/MEDLINE, ScienceDirect, Scopus, and Web of Science databases were searched for clinical trials and observational studies examined the effects of IF regimens such as time-restricted eating and Ramadan model of IF (RIF) on glucose homeostasis, lipid profile, inflammatory and hormonal markers in patients with PCOS.

Results

This systematic review solicited three articles, comprising a collective sample size of 75 females diagnosed with PCOS. The studies were published between 2015 to 2023 and were undertaken in three countries: China, Turkey, and Iran. The research articles examined the effects of intervention with IF and CR on PCOS-related parameters such as anthropometric measures and biochemical tests which included enzymes, glycemic control, lipid profile, hormonal, and oxidative stress, and inflammatory markers. The articles yielded mixed results, with two of them showing significant changes across all tested parameters. One of the three studies did not exhibit any significant changes.

Conclusion

Very limited studies examined the relationship between IR and CR with markers of PCOS. Further well-controlled studies need to be undertaken the combined results from the limited studies illustrate the intricate and diverse nature of IF, including the RIF, and its influence on measurements of body composition and biochemical markers related to PCOS.