bluuebunny/crossref_metadata_2025 huggingface dataset:
Crop Modeling and the Identification of Stable Coefficients that May Reflect Significant Groups of Genes
Authors: Hunt L. A. , Reynolds M. P. , Sayre K. D. , Rajaram S. , White J. W. , Yan W.
Published: October 2021

Knowledge about the functioning of a crop system can be embedded in simulation models of crop growth and development. Such quantitative models have until now made extensive use of physiological knowledge, but modeling could benefit greatly by incorporating genetic information. Equally, because models can help resolve environmentally varying characteristics into stable characteristics that reflect groups of genes, genomics research could benefit from modeling efforts. The use of the model Cropsim to analyze wheat (Triticum aestivum L.) growth and development is demonstrated. Data on reproductive development were well fitted when the life cycle was divided into phases, although photoperiodic sensitivity varied between phases. Describing leaf appearance satisfactorily required introducing an effect of photoperiod. Understanding the need for a breakdown into phases of development, for varying photoperiodic sensitivities, and for photoperiodic control of leaf appearance, could be enhanced by genomic studies. Simulating growth of wheat over successive seasons required changing supposedly stable genotypic characteristics. Furthermore, growth of near inbred lines incorporating the Lr19 chromosome translocation varied with genotypic background. These results also indicate that, given the variation in modeling outputs from year to year, care should be taken in the application of models to long‐term problems, and that efforts should be devoted to model improvement. Further development of crop models will benefit from associating genomic analysis with field experiments and model analyses. Much could be gained from increased interaction among model developers, field experimenters, and genomics researchers.
Nitrogen Fertility Effects on Bt δ‐Endotoxin and Nitrogen Concentrations of Maize during Early Growth
Authors: Bruns H. Arnold , Abel Craig A.
Published: October 2021

Nitrogen deficiencies interfere with protein synthesis and growth in general in maize (Zea mays L.). Transgenic maize hybrids with the Bacillus thuringiensis Berliner (Bt) gene produce proteins that are solubilized and become insecticidal in the highly alkaline midgut of certain lepidopteran insects. The effect N fertility has on Bt δ‐endotoxin and how whole‐plant N concentrations relate to Bt δ‐endotoxin levels has yet to be documented in early‐growth maize. Two Bt maize hybrids (‘Pioneer 33V08’1 with Bt event MON‐810 and ‘Dekalb 626Bty’1 with Bt event DBT 418) were grown in pots in duplicate greenhouse experiments with N fertility rates of 0, 112, 224, and 336 kg ha−1 N as NH4NO3. Fertilizer was blended into a potting mixture of a 2:1:1 ratio of peat moss/sand/soil at planting. Plants were harvested at growth stage V5 and assayed for Bt δ‐endotoxin using a commercial quantification plate kit. Whole‐plant N concentrations were determined by semimicro‐Kjeldahl. Whole‐plant N concentrations were 25.8, 33.1, 35.1, and 37.7 mg g−1, and Bt δ‐endotoxin concentrations were 350, 367, 486, and 534 μg kg−1 at N fertility levels of 0, 112, 224, and 336 kg ha−1, respectively. Increased available N likely increases Bt δ‐endotoxin–synthesizing proteins and thus increases the Bt δ‐endotoxin concentration. The response of the two Bt hybrids to increased N fertility was similar. Adequate levels of N fertility during early growth appear essential for Bt δ‐endotoxin production by the plant and may affect the ability of maize plants to resist insect predation.
Crop Modeling, QTL Mapping, and Their Complementary Role in Plant Breeding
Authors: Yin Xinyou , Stam Piet , Kropff Martin J. , Schapendonk Ad H. C. M.
Published: October 2021

Crop modelers and geneticists have developed a vision of their roles in plant breeding from their own perspective. However, to improve breeding efficiency, interdisciplinary collaboration becomes increasingly important. The objective of this paper is to explore opportunities for collaboration between modelers and geneticists in ideotype breeding for high crop yield. The advent of molecular markers enables variation of a complex trait to be dissected into the effects of quantitative trait loci (QTL) and assists the transfer of these QTL into desired cultivars or lines. A recent study in which QTL information was linked to crop modeling has shown that QTL analysis removes part of random errors of measured model input parameters and that QTL information can successfully be coupled with crop models to replace measured parameters. The QTL‐based modeling overcomes the limitations in designing ideotypes by using models that ignore the inheritance of model input traits. On the other hand, crop modeling can potentially be a powerful tool to resolve genotype × environment interactions and to dissect yield into characters that might be under simpler genetic control. Based on the complementary aspects of crop modeling and QTL mapping, we propose an approach that integrates marker‐assisted selection into model‐based ideotype framework to support breeding for high crop yield. For this approach to be effective, there is a need to develop crop models that are capable of predicting yield differences among genotypes in a population under various environmental conditions.
MtNOOT gene enhanced high productivity and economical characteristics of tomato (Lycopersicon esculentum)
Authors: El-Heba Ghada Ahmed Abu
Published: October 2021

Tomato (Lycopersicon esculentum) is the main vegetal crop that has tremendous popularity around the world. Medicago truncatula NOOT gene (Mt-NOOT) encodes a BTB/POZ-ankyrin repeat protein of the NONEXPRESSOR OF PR GENES1 (NPR1 family). It was introduced into Lycopersicon esculentum (Tomato) genome. The tomato plants that ectopically expressed Mt-NOOT obtained several favorable traits and fruit quality. Heteroblasty between the transgenic and the non-transgenic tomato leaves and flower architecture were used to distinguish transgenic and wild lines. Transgenic tomato plants accumulated a significant amount of phenolic compounds and plant pigmentations compared to the wild type. On the other hand, transgenic plants acquired a considerable amount of antioxidant such as CuZnSO superoxide dismutase (SOD), tomato Catalase (CAT), and tomato Cell wall-associated peroxidase (TPX1) than the wild type. Antioxidant high content together with the high content of phenolic compounds enabled the transgenic tomato fruits to gain not only edible benefits, but also a significant higher shelf-time, extended to six months more than the wild type stored at 25°C in dark and dry condition. Surprisingly, transgenic tomato fruits did not show any rotten process during long time storage as they did not acquire any contagious microorganism. Total fruit productivity in transgenic tomato was greater than the control with an estimated ratio of 84%.
Quality of soybean seeds submitted to different treatments and storage conditions
Authors: Silva Francielen Lima da , Medeiros Letícia Barão , Ferreira Fabiano Carlos , Meneghello Géri Eduardo , Villela Francisco Amaral , Aumonde Tiago Zanatta , Pedó Tiago
Published: October 2021

Chemical seed treatment is a recommended technique to protect seeds from pathogens that can affect their quality. The objective of this work was to analyse the quality of soybean seeds with different treatments under different storage temperatures. Seeds of cultivar ‘M 8378 IPRO’ produced in Mato Grosso, Brazil were used. A completely randomised design was used in a 4 × 3 two-factorial scheme. The seeds were treated with three different combinations of chemicals (fungicides, insecticides, polymer and drying powder) in addition to the control (untreated seeds) combined with three different storage temperatures (13 °C, 19 °C and uncontrolled temperature), with three repetitions. Quality was assessed by the germination test (TG), accelerated aging (AA), field emergence (FE), tetrazolium test (TZ) and isoenzyme analysis. The uncontrolled storage temperature negatively influenced the variables germination, accelerated aging and field emergence. The vigour and viability of the tetrazolium test showed that untreated seeds had better physiological quality than seeds with chemical treatment. The expression of isoenzymes showed a difference between treatments. Even with the stress caused by the seed treatment, this tool is very important for the initial protection of the seedlings.
Daily probiotics: benefits and reasonable application
Authors: Shulpekova Yu. O. , Rusyaev V. Yu.
Published: October 2021

This article reviewed the mechanisms of action of probiotics and the possible effects of individual strains on the general wellbeing if they are taken daily.

The content and activity of bacteria in food products should be regulated by special guidelines. The balanced nutrition allows us to get healthy strains in a natural way. Daily consumption of certain strains as part of functional food products is promising for the prevention of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, functional intestinal disorders, colon cancer, cardiovascular diseases and depression. The issues of safety of novel probiotic strains newly introduced in clinical practice require careful consideration. Synbiotics can comprise probiotic strains of bacteria (Lactobacillus acidophilus La-14, Lactobacillus rhamnosus Lr-32, Bifidobacterium lactis Bl-04) with tolerance to acid, pepsin and bile salts, as well as the prebiotic inulin and vitamins B1, B2, B6 and B12 contributing to survival of beneficial bacteria. L. acidophilus is a common probiotic that occurs in the natural environment and food products, no cases of antibiotic resistance of this species have been established. Strains Lactobacillus acidophilus La-14, Lactobacillus rhamnosus Lr-32, Bifidobacterium lactis Bl-04 have a high adhesion capacity, strong inhibitory effects on intestinal pathogens, including fungi, anti-inflammatory effects, help to eliminate oxalates. As can be seen from the above, the use of probiotics and synbiotics is one of the most promising preventive fields of medicine.
Dietary therapeutic and preventive food products in complex therapy of gastroinal tract diseases associated with Helicobacter pylori
Authors: Pilat T. L. , Kuzmina L. P. , Bezrukavnikova L. M. , Kolyaskina M. M. , Korosteleva M. M. , Ismatullaeva S. S. , Khanferyan R. A.
Published: October 2021

Introduction. The paper presents modern literature and clinical research data on the efficacy and safety of dietary therapeutic and prophylactic foods in the complex therapy of diseases associated with Helicobacter pylori. Aim. To assess the efficacy and safety of the use of dietary therapeutic and prophylactic food products in the complex therapy of diseases of the gastrointestinal tract associated with Helicobacter pylori. Materials and methods. To evaluate the efficacy of dietary therapeutic and prophylactic food products such as Vegetable Puree Soup with Herbs and Oatmeal, Oatmeal Porridge with Herbs and Flax Seed, Protein-Sea Buckthorn Cocktail (LEOVIT Nutrio LLC), the main group of patients with gastrointestinal diseases (n = 41) was formed, which was further divided into four subgroups. Each of three subgroups received one specialty food product, and the fourth subgroup received all three products. Changes in complete blood count were evaluated using Sysmex XT-2000i analyzer, those in proteinograms – using SAS1, SAS2 protein fraction analyser and those in metabolic liver disorders, lipid profile and glucose level – using Konelab PRIME 30i (Thermo Fisher Scientific) analyzer. All parameters were studied three times: before use, 14 and 60 days after use of the products. Results and discussion. After 14 days, complaints of lack of appetite decreased in the main group, discomfort in the epigastrium, feeling of heaviness and nausea decreased. After 60 days, 100% of patients reported no heartburn, belching, nausea, pain, rumbling in the abdomen, appetite and stool returned to normal. There was a marked significant (p < 0.05) decrease in the level of alpha-1 globulin against the background of an increase in albumin, a decrease in the concentration of CRP and ESR, the levels of leukocytes and neutrophils in all subgroups of the main group after 60 days. Conclusions. The investigated products are safe, no adverse reactions were noted, including the phenomena of intolerance and allergies, and are recommended for use in dis[1]eases of the gastrointestinal tract associated with Helicobacter pylori.
Degradation of tetracycline using nanoparticles of zero-valent iron and copper
Authors: Ayoub Mohamed
Published: October 2021

Tetracycline (TC) is one of the most persistent pharmaceuticals in the ecosystem. Advanced oxidation processes (AOPs) are suitable and effective technology for treating wastewater contaminated with antibiotics such as TC. In this manner, Fenton-like reaction is effective for wastewater treatment from toxicity and non-biodegradable organic pollutants using bimetallic nanoparticles. This study aims to verify the effect of AOPs using ZVI/Cu bimetallic nanoparticles on removing the TC antibiotic via a Fenton-like reaction, and what is necessary to evaluate the factors that influence the reaction, i.e. pH, ZVI/Cu dose, stirring intensity, H2O2 concentration, and initial TC dosage. The obtained results indicated that the TC removal reached up to 82.3% with an initial TC dose of 8 μg/L. In addition, the TC degradation process is more effective in an acidic medium than in an alkaline medium. Furthermore, the TC removal reached up to 85.1% with a ZVI/Cu dose of 1.2 g/L. On the other hand, the optimum mixing intensity value was 200 rpm, and the optimum H2O2 dose was 2 g/L according to the conditions of the present study.
Features of the course of the gestational process with the carriage of genotypes F5L:G(1961)A and F2:G(20210)A and inheritance options
Authors: Nikolaeva M. G. , Strozenko L. A. , Yasafova N. N. , Momot A. P.
Published: October 2021

Aim of the study – to establish the features of inheritance of the F5L:G(1961)A and F2:G(20210)A genotypes and to assess their influence on the course and outcomes of pregnancy.Materials and methods. The object of the study was 70 mother–child pairs: 50 women, carriers of the F5L:G(1961)A mutation, and their children; 20 female patients, carriers of the F2:G(20210)A mutation, their children. Additionally, 18 families of women, carriers of the factor V Leiden mutation, in three generations were studied.Results. Carriage of the F5:(1961)GA and F2:(20210)GA genotypes in fetuses is associated with the risk of developing gestational complications in their mothers, which are primarily realized when the maternal laboratory phenotype is manifested. A higher frequency of occurrence of the minor allele A20210 of the FII gene was determined in children than in the older generation (p = 0,0006).
A review of pharmacogenetic aspects of methotrexate and 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia treatment
Authors: Gurieva О. D. , Savelyeva М. I. , Valiev Т. Т.
Published: October 2021

Significant progress in the treatment of acute lymphoblastic leukemia (ALL) in children has resulted from the development of effective chemoand supportive care therapy protocols. The vector of further research is aimed at reducing toxicity and long-term side effects. The study of pharmacogenetic aspects of toxicity of the main drugs used in the treatment of ALL – methotrexate and 6-mercaptopurine – allowed to identify oligonucleotide polymorphisms that correlate with the concentration of the drug in blood, toxic effects and the risk of relapse of ALL. The clinical administration of pharmacogenetic methods remains a challenging task, requiring additional research, which will make it possible to individualize the ALL therapy on the basis of the results of molecular profiling.
The use of Jelonet dressings in the treatment of drug toxicity in autologous stem cell transplantation in children. Clinical case presentation
Authors: Aliev T. Z. , Belysheva T. S. , Sergeenko K. A. , Machneva E. B. , Sidorova N. V. , Valiev T. T. , Kostareva I. O. , Kirgizov K. I.
Published: October 2021

One of the complications arising at the stage of hematopoietic stem cell transplantation (HSCT) is skin lesions. This complication is quite common and represents an important diagnostic and therapeutic problem. The main cause of skin lesions in HSCT is drug toxicity, but also infectious lesions. Each of the complications can manifest itself in varying degrees, as well as be combined with others, having a significant negative effect on the patient’s condition, in severe cases posing a threat to the patient’s life. This paper presents a clinical case of a patient with treosulfan toxicoderma who was treated with JELONET dressings.
A Case of Intratumoral and Hepatic Portal Venous Gas in Patient with Gastric Cancer Liver Metastases
Authors: Karabulut Ummuhan Ebru , Gultekin Mehmet Ali , Sari Lutfullah , Kılınc Yagmur Basak
Published: October 2021

Background:

Hepatic portal venous gas [HPVG] is not a common finding in daily practice. It is usually associated with mesenteric ischemia and bowel necrosis in adults. Combination of intratumoral gas in metastatic liver lesions with HPVG is quite rare and thought to be associated with chemotherapy-induced necrosis and infection of the necrotized metastasis.

Objective:

Here we present a case of gastric adenocarcinoma with portal venous and intratumoral gas in metastatic liver lesions due to the infected necrosis.

Case Presentation:

The patient was presented to the emergency room with severe abdominal pain and septic condition after the second round of chemotherapy. Hepatic portal venous and intratumoral gas in metastatic liver lesions due to the infected necrosis of liver metastasis was detected in computed tomography images. There were no findings of mesenteric ischemia both clinically and radiologically. Massive intratumoral infected necrosis in metastatic liver lesions and fistulization to the right portal vein branches were detected on abdominopelvic CT. Secondary infection of the necrotic metastases and fistulization to portal vein branches was believed to cause the air in metastatic liver masses and portal venous gas.

Conclusion:

Infected necrosis of metastatic liver lesions and fistulizations to the portal venous structures is extremely rare. Clinicians and radiologists should be aware of such a rare complication because early detection is crucial for patient management.
Formulation and Standardization of Anti-acne Herbal Foaming Face Wash using Curcuma longa along with Aloe vera, Rosa centifolia, and Citrus sinensis
Authors: Lal Niharika , Rana Maharabi , Sagar Bhanu P. S. , Verma Navneet
Published: October 2021

Objectives:

Acne vulgaris is a very common skin disorder that peaks in teenagers, but
many men and women between 20-40 years of age are also affected by the disorder. For the treatment
of acne, herbal medications are considered safer than allopathic medicines as allopathic
medicines are associated with side effects, such as contact allergy, local irritation, scaling, photosensitivity,
itching, and redness of the skin, etc. The present research work was performed to check
the effectiveness of foaming face wash formulation containing Curcuma longa along with herbals
excipient Aloe vera, Rosa centifolia, and Citrus sinensis. Curcuma longa has been reported to contain
active phytoconstituents having significant anti-microbial activity and being used locally for
acne.

Method:

The plant materials Curcuma longa, Aloe vera, Rosa centifolia, and Citrus sinensis were
authenticated, and their extracts have been prepared using Soxhlet Apparatus and the resulting essential
oil was analyzed for its physical properties. The foaming face wash was then prepared by using
the herbal extracts with excipients that were free from sulfates, parabens, silicone, and
petroleum products. Two formulations, A1and A2, have been prepared and their physicochemical
studies were performed. The presence and efficacy of Curcuma longa in the suppression of Propionibacterium
acnes were assessed by analytical methods and anti-microbial techniques, respectively.
Skin irritation studies were conducted using Wistar rats by the scoring method. Accelerated stability
studies were also performed for 60 days.

Result:

The physicochemical properties were evaluated and found to be satisfactory. Analytical
techniques like High-Performance Liquid Chromatography, High-Performance Thin Layer Chromatography,
and Infra-Red spectral analysis confirmed the qualitative presence of Curcuminoid,
which is a mixture of curcumin, desmethoxycurcumin (4-hydroxycinnamoyl-(4-hydroxy-3-methoxycinnamoyl)
methane), and Bis- demethoxycurcumin (bis-(4-hydroxy cinnamoyl) methane) in
the sample. The antibacterial activity of developed face wash assessed against Propionibacterium
acnes was more than that of Clindamycin (10μg/ml). Also, the developed formulation showed very
high activity against Staphylococcus epidermidis concerning the activity of the standard clindamycin.
The prepared formulation showed no sign of localized reactions, which were confirmed
by a skin irritation study, indicating the formulation was safe and compatible with the skin.

Conclusion:

Based on our study, it could be stated that the formulation has antimicrobial activity
and could be used safely on human skin.
On the Critical Resolved Shear Stress and its Importance in the Fatigue Performance of Steels and other Metals with Different Crystallographic Structures
Authors: Mlikota M.
Published: October 2021

This study deals with the numerical estimation of the fatigue life represented in the form of strength-life (S-N, or Wöhler) curves of metals with different crystallographic structures, namely body-centered cubic (BCC) and face-centered cubic (FCC). Their life curves are determined by analyzing the initiation of a short crack under the influence of microstructure and subsequent growth of the long crack, respectively. Micro-models containing microstructures of the materials are set up by using the finite element method (FEM) and are applied in combination with the Tanaka-Mura (TM) equation in order to estimate the number of cycles required for the crack initiation. The long crack growth analysis is conducted using the Paris law. The study shows that the crystallographic structure is not the predominant factor that determines the shape and position of the fatigue life curve in the S-N diagram, but it is rather the material parameter known as the critical resolved shear stress (CRSS). Even though it is an FCC material, the investigated austenitic stainless steel AISI 304 shows an untypically high fatigue limit (208 MPa), which is higher than the fatigue limit of the BCC vanadium-based micro-alloyed forging steel AISI 1141 (152 MPa).
The Rise and Fall of International Law in the Post-Lisbon AFSJ Legislation Cycles
Authors: Fahey Elaine
Published: October 2021

The article focuses on the output and incidence of international law in the adopted AFSJ law-making for the period between 2009−14 and 2014−19, with particular emphasis upon asylum and immigration law. The article thus overall shows an initially rising but subsequently falling ‘international’ influence upon EU AFSJ directives and regulations. International law usage is significant even in times of populism or times of crisis-related law-making, particularly as to asylum and immigration law. However, the waning presence of international law also arguably indicates the development of the AFSJ as a booming legal field, where there is an operationalisation of a vast field of new actors, institutions, and systems through EU law. This account demonstrates how the EU shows a tangible intent to permit the influence of international law upon the AFSJ which supports well its general efforts to participate and engage as a global legal actor.
The effect of virtual instrument system laboratory to enhance technological literacy and problem-solving skills among junior high school students
Authors: Supahar Supahar , Widodo Eko
Published: October 2021

This study aims at analyzing the effect of the Virtual Instrument System Laboratory (Vis-Lab) to enhance technological literacy and problem-solving skills among junior high school students. This type of research can be categorized as Quasi-experimental research with Nonequivalent Control Group Design. The subjects of this study were the seventh-grade students in one of the junior high schools in Sleman Regency, Yogyakarta. The research instrument consisted of pretest and posttest on technological literacy and problem-solving skills. The data analysis technique used N-Gain analysis, prerequisite test, hypothesis testing with MANOVA, and effect size. Based on the MANOVA test, the Sig. value of 0,000 <α (0.05) indicated that there was a gap in the students’ technological literacy and problem-solving skills between the control and the experimental class. The use of VIS-Lab learning media enhanced the ability of technological literacy by 9.0% for the experimental class and 2.1% for the control class respectively. Meanwhile, the effective contribution to the use of VIS-Lab learning media was 36.5% for the experimental class and 4.73% for the control class. It means that the use of VIS-Lab learning media contribute effectively to improving the ability of technological literacy and problem-solving.
Valoración Multicriterio de atractivos y recursos turísticos en el municipio Usiacurí – Atlántico - Colombia
Authors: Moreno Zahira , Ziritt Trejo Gertrudis , Ramos Marcela
Published: October 2021

El propósito de esta investigación es establecer una valoración multicriterio de los atractivos y recursos turísticos del municipio Usiacurí, dado que es una zona con mucho potencial turístico. En tal sentido se hace necesaria una adecuada planificación para que el municipio Usiacurí sea considerado como un destino turismo sostenible e integral que contribuya con el desarrollo local. Para la valoración multicriterio de los recursos y atractivos turísticos se partió de la guía para la elaboración de inventarios turísticos del Ministerio de Comercio, Industria y Turismo, así como del Viceministerio de Turismo – Colombia 2011. Se visitaron veinticinco (25) sitios del municipio con potencial turístico, y se realizaron entrevistas a algunos de los habitantes del municipio. El estudio es descriptivo, de campo – documental, elaborado bajo un enfoque argumentativo explicativo. Los resultados arrojados indican que se cuenta con un inventario de recursos turísticos, que permite diseñar productos turísticos sostenibles para el municipio.
Effects of Social Networking Service (SNS) Addiction on Mental Health Status in Chinese University Students: Structural Equation Modeling Approach Using a Cross-sectional Online Survey
Authors: Wang Tingxuan , Wong Janet Y H , Wang Man Ping , Li Amanda Chiu Yin , Kim Sang Suk , Lee Jung Jae
Published: October 2021

Background

Although social networking services (SNSs) have become popular among young people, problematic SNS use has also increased. However, little is known about SNS addiction and its association with SNS use patterns and mental health status.

Objective

This study aims to test the mediating role of SNS addiction between SNS use patterns and mental health status among Chinese university students in Hong Kong (HK).

Methods

An online cross-sectional survey was conducted using a convenience sampling method. In total, 533 university students (323 [66.9%] female, mean age [SD]=20.87 [2.68] years) were recruited from February to March 2019. Multiple linear regression was used to assess the association between SNS use and SNS addiction. Structural equation modeling (SEM) was performed to examine the pathways and associations among SNS use, SNS addiction, psychosocial status, and mental health status (including anxiety and depressive symptoms).

Results

A longer time spent on SNSs per day (>3 h), a longer time spent on each SNS access (≥31 min), a higher frequency of SNS access (≤every 30 min), a longer duration of SNS use before sleeping (≥61 min), and a shorter duration from waking to first SNS use (≤5 min) were significantly associated with a higher level of SNS addiction (adjusted beta [aβ]=6.03, 95% CI 4.66-7.40; aβ=4.99, 95% CI 3.14-6.83; aβ=5.89, 95% CI 4.14-7.64; aβ=5.92, 95% CI 4.19-7.65; and aβ=3.27, 95% CI 1.73-4.82, respectively). SEM showed a significant mediating effect of SNS addiction in the relationship between SNS use and psychosocial status, and mental health status, including an indirect effect (β=0.63, 95% CI 0.37-0.93) and the total effect (β=0.44, 95% CI 0.19-0.72), while the direct effect was insignificant (β=–0.19, 95% CI –0.49 to 0.08).

Conclusions

SNS use patterns were associated with SNS addiction, and SNS addiction mediated the associations between SNS use, psychosocial status, and mental health status of Chinese university students in HK. The findings suggest that screening for and addressing excessive SNS use are needed to prevent SNS addiction and mental distress among young people.
Verifying the Feasibility of Implementing Semantic Interoperability in Different Countries Based on the OpenEHR Approach: Comparative Study of Acute Coronary Syndrome Registries
Authors: Min Lingtong , Atalag Koray , Tian Qi , Chen Yani , Lu Xudong
Published: October 2021

Background

The semantic interoperability of health care information has been a critical challenge in medical informatics and has influenced the integration, sharing, analysis, and use of medical big data. International standard organizations have developed standards, approaches, and models to improve and implement semantic interoperability. The openEHR approach—one of the standout semantic interoperability approaches—has been implemented worldwide to improve semantic interoperability based on reused archetypes.

Objective

This study aimed to verify the feasibility of implementing semantic interoperability in different countries by comparing the openEHR-based information models of 2 acute coronary syndrome (ACS) registries from China and New Zealand.

Methods

A semantic archetype comparison method was proposed to determine the semantics reuse degree of reused archetypes in 2 ACS-related clinical registries from 2 countries. This method involved (1) determining the scope of reused archetypes; (2) identifying corresponding data items within corresponding archetypes; (3) comparing the semantics of corresponding data items; and (4) calculating the number of mappings in corresponding data items and analyzing results.

Results

Among the related archetypes in the two ACS-related, openEHR-based clinical registries from China and New Zealand, there were 8 pairs of reusable archetypes, which included 89 pairs of corresponding data items and 120 noncorresponding data items. Of the 89 corresponding data item pairs, 87 pairs (98%) were mappable and therefore supported semantic interoperability, and 71 pairs (80%) were labeled as “direct mapping” data items. Of the 120 noncorresponding data items, 114 (95%) data items were generated via archetype evolution, and 6 (5%) data items were generated via archetype localization.

Conclusions

The results of the semantic comparison between the two ACS-related clinical registries prove the feasibility of establishing the semantic interoperability of health care data from different countries based on the openEHR approach. Archetype reuse provides data on the degree to which semantic interoperability exists when using the openEHR approach. Although the openEHR community has effectively promoted archetype reuse and semantic interoperability by providing archetype modeling methods, tools, model repositories, and archetype design patterns, the uncontrolled evolution of archetypes and inconsistent localization have resulted in major challenges for achieving higher levels of semantic interoperability.
Vitamin K Insufficiency in the Indian Population: Pilot Observational Epidemiology Study
Authors: Vaidya Rama , Vaidya Ashok D B , Sheth Jayesh , Jadhav Shashank , Mahale Umakant , Mehta Dilip , Popko Janusz , Badmaev Vladimir , Stohs Sidney J
Published: October 2021

Background

The fat-soluble K vitamins K1 and K2 play an essential role in the blood coagulation cascade and are made available predominantly through selective dietary intakes. They are less known for their nonessential roles in a family of vitamin K–dependent proteins that promote various functions of organs and systems in the body. A lack of vitamin K can characterize vitamin and nutritional element insufficiency, which is different from a clinically apparent vitamin deficiency.

Objective

This epidemiological study evaluated the nutritional status of vitamin K in a sample of the Indian population and vitamin K content in staple Indian foods.

Methods

Serum levels of vitamin K1 and vitamin K2 in the form of menaquinone-7 (MK-7) were assessed via high-performance liquid chromatography coupled with fluorescence detection in 209 patients with type 2 diabetes, 50 healthy volunteers, and common staple foods in India.

Results

After comparing populations with high and low serum vitamin K levels from various geographical regions, our results indicated that the sample of healthy Indian individuals and the sample of Indian patients with type 2 diabetes had low (insufficient) levels of vitamin K2 (MK-7; range 0.3-0.4 ng/mL). No significant differences existed in vitamin K1–related and MK-7–related values between healthy male and female subjects, between male and female subjects with diabetes, and between the healthy sample and the sample of patients with diabetes. The staple, commonly consumed Indian foods that were tested in this study had undetectable levels of vitamin K2, while levels of vitamin K1 varied widely (range 0-37 µg/100 g).

Conclusions

Based on our sample’s low serum levels of vitamin K2 (MK-7) as well as the low levels of vitamin K2 in their typical diet, we propose that the general Indian population could benefit from the consumption of vitamin K2 in the form of MK-7 supplements.

Trial Registration

Clinical Trials Registry - India CTRI/2019/05/014246; http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=21660&EncHid=&userName=014246; Clinical Trials Registry - India CTRI/2019/03/018278; http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=32349&EncHid=&userName=018278
Effects of COVID-19 and diabetes mellitus on apolipoprotein A1 level in the blood plasma of patients
Authors: Pushkarev V.V. , Sokolova L.K. , Cherviakova S.A. , Belchina Yu.B. , Bigun M.V. , Kovzun O.I. , Pushkarev V.M. , Tronko M.D.
Published: October 2021

Background. Increased level of high-density lipoprotein (HDL) cholesterol and apolipoprotein A1 (ApoA1) in plasma is associated with a reduced risk of developing cardiovascular diseases. In addition to its potential cardioprotective function, HDL and ApoA1, the main HDL apolipoprotein, also have antidiabetic properties. The aim of the study was to determine the level of ApoA1 in the blood of patients (n = 81) with diabetes mellitus and COVID-19. Materials and methods. ApoA1 was determined by enzyme-linked immunosorbent assay kits (Elabscience, USA). The measurements were performed at an optical density of 450 nm. Results. ApoA1 level in the blood of patients with diabetes and especially with COVID-19 was significantly lower than in healthy people. The study of the dependence of plasma ApoA1 content on the level of Hb1Ac, the gender and the type of diabetes showed that in blood of patients with type 2 diabetes the amount of ApoA1 is lower than in those with type 1 diabetes, and with an increase in the level of Hb1Ac the amount of ApoA1 decreases. There was also significant gender difference. With an increase in the body mass index, the content of ApoA1 in blood plasma decreases below normal — 0.9 g/L, and at body mass index < 25 kg/m2, the amount of ApoA1 is significantly higher than the average lipoprotein level in diabetic patients. In individuals with newly diagnosed diabetes, the level of ApoA1 is significantly higher, and in patients with more than 10 years of illness, it is below average and below normal. Biguanide treatment, either in combination with other drugs (mainly insulin) or as monothe-rapy, does not significantly affect the level of ApoA1 compared to the entire group average. In patients treated with sulfonylurea, the level of ApoA1 is significantly lower than the average level for the group and the norm. A significant positive effect on the amount of ApoA1 in plasma was observed in people treated with a combination of drugs with sodium-glucose cotransporter type 2 inhibitors, insulin and especially dipeptidyl peptidase-4 inhibitors. However, insulin monotherapy did not significantly affect the ApoA1 content. Possible mechanisms of ApoA1 decrease in COVID-19 and diabetes are discussed. Conclusions. Thus, the level of ApoA1 may be one of the promising markers of severe COVID-19.
Budesonide/formoterol versus salmeterol/fluticasone for asthma in children: an effectiveness and safety analysis
Authors: Jiang Ping , Zhao Lanyu , Yao Zezhong
Published: October 2021

Background:
The efficacy of budesonide + formoterol therapy compared with high-dose salmeterol + fluticasone therapy plus short-acting β-agonist (SABA) has not been evaluated specifically in children.
Objectives:
To evaluate the efficacy and safety of budesonide + formoterol combination therapy two times a day plus as needed compared with salmeterol + fluticasone two times a day plus SABA (as needed) in children in China.
Methods:
This prospective cohort study included 164 children with persistent asthma (aged 12–17 years) who had experienced a minimum of one asthma exacerbation in 12 months prior to the study. The primary outcome was the time to the first severe exacerbation.
Results:
Eighty-two children were assigned to each of two groups. The exacerbation rate per 100 patients per year was not found to be significantly different. The number of patients with hospitalization/emergency room therapy was lower in budesonide + formoterol group, but the risk difference was not statistically significant. Asthma control measures showed comparable effects. Both treatments were well-tolerated.
Conclusion:
No significant differences were observed in the outcome measures between the groups. Budesonide + formoterol therapy is a favorable approach in terms of a low load of ICS, steroid exposure, need for multiple inhalers and cost.
Potentials of Chenpi on Metabolic Syndrome: A Review
Authors: Lee Yoo-na , An Yu-min , Kim Jun-seok , Baek Kyungmin
Published: October 2021

Objectives: Metabolic Syndrome (MetS) is strongly related with central obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol (HDL-C), hyperglycemia, and hypertension. This study reviewed the potential of Chenpi in treatment of MetS through amelioration of co-related diseases, such as diabetes mellitus, hyperlipidemia, obesity, hepatic steatosis, and inflammation.Methods: Six electronic databases (Oriental Medicine Advanced Searching Integrated System (OASIS), Korean Traditional Knowledge Portal, Korea Institute of Oriental Medicine (KIOM), Research Information Sharing Service (RISS), PubMed, and Embase) were used to search for in vitro, in vivo, and clinical research that discusses the potential effects of Chenpi (Citrus unshiu Markovich, Citrus reticulata Blanco) on diabetes mellitus, hyperlipidemia, obesity, hepatic steatosis, and inflammation.Results: This review suggests the potential of Chenpi as a candidate for the treatment of metabolic syndrome through improvement of co-related diabetes, hyperlipidemia, obesity, hepatic steatosis, and inflammation. However, comparison of the results of each study was limited by a lack of quantification of the experimental materials.
Styring og lederskab er skabt af mennesker og rettet mod menneskers adfærd
Authors: Melander Preben
Published: October 2021

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Incidência de mastigação unilateral em crianças com dentição decídua e dentição mista em estágio inicial com alimentos fibrosos e macios
Authors: Santiago Junior Orlando
Published: October 2021

No abstract available
Cisto ósseo aneurismático: apresentação de um caso
Authors: Batista Burzlaff João , Franco Neto da Costa Carlos Alfredo , Silveira da Fontoura Heloísa , Nunes da Rosa Lauro , Quadros Onofre
Published: October 2021

The authors present a clinical case of aneurysmathic bone cyst, discussing its pathogenesis and histologycal and clinical aspects.
A Case Report of a Cecal Bascule with Internal Herniation through the Foramen of Winslow
Authors: Mulkey Eric , Stewart Gregory , Enrique Ernesto , El-Sabrout Rafik
Published: October 2021

Internal hernias are a rare phenomenon, and even rarer is a herniation
through the foramen of Winslow. We report a rare case of an 81 year old
female presenting with vague abdominal symptoms who was found to have a
cecal bascule herniating through the foramen of Winslow treated with
surgery.
The impact of patient-dependent risk factors on morbidity and mortality following gastric surgery for malignancies
Authors: Dumitriu Bogdan , Valcea Sebastian , Andrei Gabriel , Beuran Mircea
Published: October 2021

Gastric cancer remains a leading cause of mortality worldwide. The treatment for gastric cancer is multimodal, in which gastrectomy remains the only curative approach. However, gastric resection is often associated with increased morbidity and mortality rates, depending on several factors. These factors can be attributed to the patient as comorbidities or effects of the disease upon him and, on the other hand, there are risk factors independent of the patient, such as aspects of the tumor (type, staging, location), experience of the surgical and anesthetic team, logistics of the hospital, yield of adjuvant therapies etc. We recognize the fact that patient-related risk factors are often overlooked and not taken into consideration prior to surgery, thus becoming a source of morbidity and mortality. These factors are more susceptible to modulating in order to better select candidates for gastric resection and thus create a better outcome. Therefore, identifying and modulating patient-related risk factors is paramount in order to decrease the incidence of morbidity and mortality following gastric resections.
Klebsiella pneumoniae cryptogenic liver abscess and endophthalmitis – a case report and review of literature
Authors: Grecescu Mihai , Grecescu Monica , Smarandache Andreea , Branescu Cristian , Anghelache Anca , Dumitriu Anca , Paunica Stana , Costea Andreea
Published: October 2021

Klebsiella pneumoniae has emerged as the predominant pathogenic agent of liver abscess in Asia, and the incidence is increasing worldwide. Hypervirulent strains are associated with septic metastatic dissemination in the eyes, lungs, and central nervous system, causing severe morbidity. We present the case of a 54year old man, with no previous comorbidities, admitted in emergency for the blind red painful eye. Further investigation documented septic endophthalmitis with transscleral extension and orbital cellulitis. Thoraco-abdominal computed tomography evidenced a hepatic abscess as the locus of the primary infection. Intravenous antibiotherapy with cefuroxime, followed by meropenem and vancomycin were efficient for managing the hepatic abscess. However, as the eyeball was perforated at the admission, evisceration was performed. The vitreous sample revealed Klebsiella pneumoniae, with a positive string test as the etiologic agent. The diagnostic and therapeutic management required a permanent collaboration between an ophthalmologist, infectious diseases specialist, surgeon, and radiologist.
Norm bounds for the inverse and error bounds for linear complementarity problems for {P1,P2}-Nekrasov matrices
Authors: Nedovic M. , Cvetkovic Lj.
Published: October 2021

{P1,P2}-Nekrasov matrices represent a generalization of Nekrasov matrices
via permutations. In this paper, we obtained an error bound for linear
complementarity problems for fP1; P2g-Nekrasov matrices. Numerical examples
are given to illustrate that new error bound can give tighter results
compared to already known bounds when applied to Nekrasov matrices. Also, we
presented new max-norm bounds for the inverse of {P1,P2}-Nekrasov matrices
in the block case, considering two different types of block generalizations.
Numerical examples show that new norm bounds for the block case can give
tighter results compared to already known bounds for the point-wise case.
Pertinencia curricular, estudio de caso en la Institución Educativa Técnica Minuto de Dios Fe y Alegría del municipio de Lérida
Authors: Urquijo Leal Hinna Alexandra , Ñáñez Rodríguez José Julián
Published: October 2021

Este artículo presenta un estudio de caso de la pertinencia de un currículo, en una institu­ción educativa de educación básica y media. El objetivo es establecer la pertinencia curricular (interna y externa) en el contexto educativo y social, para lo cual se implementó un enfoque metodológico cualitativo, utilizando técnicas como la revisión de documental, la observación no estructurada y las entrevistas semiestructuradas a directivos, docentes, estudiantes, padres de familia y egresados. Los resultados indican que el currículo ha generado en los egresados el gusto por aprender, el orgullo institucional, la posibilidad de desempeñarse en diversas profe­siones, con pensamiento crítico y conciencia de la sociedad en la que se encuentran.
Competencias TIC y desarrollo profesional de los instructores del SENA Regional Guajira
Authors: Pérez Campuzano Alda María
Published: October 2021

Hoy en día no es suficiente solo el título profesional para demostrar la idoneidad y los conoci­mientos adquiridos, también es importante reconocer las habilidades y destrezas, es decir, las competencias que facultan y garantizan que el docente posee las capacidades necesarias para resolver de forma satisfactoria las situaciones a las que se enfrentan en su ejercicio profesional. Esta investigación tiene como objetivo principal analizar las competencias TIC y el desarrollo profesional docente en los instructores del Sena Regional Guajira. El fundamento teórico está respaldado por los postulados de Hernández (2016), Vega (2017), MEN (2013), García (2015) entre otros. Es un estudio descriptivo, no experimental, de campo y transaccional, la población conformada por los instructores del Centro Industrial y de Energías Alternativas del Sena Re­gional Guajira, usando como técnica la encuesta; como instrumento el pentágono propuesto por el Ministerio de Educación Nacional en 2013. En los resultados de la investigación se logró evidenciar los niveles de apropiación de cada uno de los instructores en relación con las com­petencias, tecnológicas, comunicativas, pedagógicas de gestión y las investigativas.
EL DETERIORO DEL MEDIO AMBIENTE Y SU RELACIÓN CON LA POBREZA EN COLOMBIA
Authors: Anaya Narváez Alfredo , Martínez Benítez Jhon , Valencia Burgos Luis Carlos
Published: October 2021

La pobreza y el deterioro del medio ambiente se encuentran íntimamente relacionados, lo cual resulta del análisis amplio que se debe hacer sobre la pobreza, no solo considerando elementos que afectan al ser humano de manera directa, como son la carencia de aquellas necesidades básicas de alimentación, salud, vivienda, educación etc. o de las que circunscriben el entorno meramenteeconómico o valoración monetaria del mismo; sino al hecho de que todos los seres humanos están inmersos en una red de interacciones que posibilitan su relación con otros seres vivos y que permiten el bienestar y aseguramiento de la especie. En efecto, los factores que inducen a la pobreza son los mismos que transgreden el bienestar de los seres vivos; los cuales se han convertido en dinamizadores del quebranto significativo del medio ambiente; la sobreexplotación de los recursos naturales, la extinción de numerosas especies animales y vegetales; el deterioro de la tierra, el agua y el aire son consecuencias que se derivan de este círculo vicioso en que los seres humanos tienen una indudable responsabilidad. Colombia no es ajena a esta problemática por lo cual se hace necesario un mayor esfuerzo de toda la sociedad para atacar las causas generadoras de pobreza que inciden positivamente en la protección del medio  ambiente.