bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS FISIK, KIMIA DAN SENSORIS TEH BUNGA KRISAN PUTIH (Chrysanthemum morifolium Ramat.) DENGAN PENGERINGAN KABINET
Authors: Hartanto Rofandi , Fitri Skolastika RF , Kawiji Kawiji , Prabawa Sigit , Sigit Bambang , Yudhistira Bara
Published: September 2022

White chrysanthemum (Chrysanthemum morifolium Ramat.) is widely used in medicine, popular drinks and as a functional food. White chrysanthemums are often used as health care products because they contain functional compounds such as phenolic compounds and antioxidant activity. Chrysanthemum is well known in Indonesia, but it has not been utilized optimally in daily life as functional food. This research is done in order to determine the effect of drying using cabinet dryer at temperatures of 40°C, 50°C, and 60°C on physical characteristics such as color and shrinkage, chemical characteristics such as moisture content, total phenol, antioxidant activity and water activity, and sensory characteristics such as color, aroma, taste, after taste and overall as well as the amount of heat required for the drying process. This research is conducted using completely randomized design. The results show that cabinet dryer at 60°C is the best drying method. Characteristics in white chrysanthemum tea are ∆E value is 39,51; long shrinkage value is 23,65%, width shrinkage is 28,46%; water content value is 6,81%; total phenol value is 15,99%; antioxidant activity value is 87,52%; water activity value is 0,25; with color 3,93 (like), aroma 3,30 (neutral), taste 3,03 (neutral), after taste 3,33(neutral) and overall 3,23 (neutral). The heat of drying at 60°C is 2.147,295kJ.
Aplikasi metode quality function deployment (QFD) dalam perancangan produk tempoyak
Authors: Hardiyanti Alavia , Karseno Karseno , Mela Ervina
Published: September 2022

Tempoyak is a food that made from fermented durian flesh with the addition of salt. In product development, one of the ways to get products that are in accordance with consumer desires is the Quality Function Deployment (QFD) method. QFDis a design method that can be used to meet customer requirements and evaluate product performance. The research objectives areknowing attributes of consumer requirements for tempoyak products, knowing the technical parameters in the manufacture of tempoyak products, and knowing the priority of consumer requirements, the level of importance and technical parameters in designing tempoyak products. The results showed that there were 17 attributes that consumers wanted, namely sweet-sour taste, yellowish white color, tempoyak aroma, price Rp. 50,000 per kilogram, there is a label on the packaging, the primary color of the transparent packaging, the small package size is 250gram, the jar packaging, the inclusion of the composition, useful for maintaining the digestive system, the inclusion of the expiration date, the inclusion of the halal logo, the inclusion of BPOM, the inclusion of the production date, the inclusion of instructions for storage , inclusion of serving suggestions, and cleanliness of the tempoyak production process. The results also show that there are 8 technical parameters, namely the preparation of raw materials, separation of durian flesh from seeds, mixing of durian meat with salt, fermentation, packaging, labeling, BPOM registration, and MUI halal registration. Attributes of consumer requirements that are of high priority are the inclusion of an expiration date, cleanliness of the tempoyak production process, the inclusion of a halal logo, a label on the packaging, and the inclusion of BPOM. Technical parameters that are of high priority in tempoyak development are labeling, preparation of raw materials, packaging, fermentation, and mixing of durian meat with salt.
ANALISIS PERMINTAAN DAGING SAPI MASYARAKAT MADURA (STUDI KASUS KABUPATEN SAMPANG)
Authors: Maulidah Maulidah , Rahayuningsih Eni Sri , Ambariyanto Ambariyanto
Published: September 2022

Penelitian ini bertujuan untuk mengetahui pengaruh harga pembelian terhadap permintaan daging sapi, untuk mengetahui pengaruh pendapatan masyarakat terhadap permintaan daging sapi dan untuk mengetahui pengaruh selera masyarakat terhadap permintaan daging sapi di Kabupaten Sampang. Penelitian ini dilakukan secara kualitatif deskriptif dengan menggunakan data primer yakni data hasil observasi dan hasil tanggapan responden dalam bentuk kuisioner dan data sekunder yakni data-data yang diperoleh dari berbagai instansi antara lain Badan Pusat Statistik Kabupaten Sampang. Hasil penelitian ini menunjukkan Keterkaitan antara tingkat harga jual daging berpengaruh terhadap permintaan daging sapi. Hal ini didukung oleh persediaan daging sapi yang mampu mencukupi permintaan masyarakat Kabupaten Sampang sehingga keadaaan ini mampu mengurangi resiko kenaikan harga daging sapi. Total pendapatan masyarakat berpengaruh terhadap permintaan daging sapi dengan tingkat pendapatan masyarakat diatas rata-rata sehingga frekuensi tingkat pembelian daging menjadi tinggi. Selera masyarakat juga terbukti berpengaruh terhadap tingkat permintaan daging sapi dimana hal ini didasari pada selera masyarakat yang mempertimbangkan tingkat kualitas daging sapi yang ada.Kata Kunci: Harga Pembelian, Pendapatan, Selera, Permintaan.
OTONOMI DAERAH, KONVERGENSI INFLASI, DAN KEBIJAKAN INFLATION TARGETING DI INDONESIA
Authors: Wahyu Hidayat Muchamad , WahyuNingsih Diah , Afin Rifai
Published: September 2022

Tujuan dari penelitian ini adalah untuk mengetahui apakah telah terjadi konvergensi/divergensi inflasi serta seberapa cepat konvergensi/divergensi inflasi yang terjadi pada daerah observasi. Pendekatan penelitian yang digunakan adalah pendekatan kuantitatif menggunakan metode Augment Dicky-Fuller Test serta metode Panel Unit Root Test yang dikembangkan oleh Im, Pesaran, dan Shin. Data yang digunakan adalah data laju inflasi bulanan 45 kota di Indonesia mulai bulan juli 2005 hingga oktober 2015. Hasil perhitungan menggunakan metode Im, Pesaran, dan Shin menunjukkan bahwa telah terjadi konvergensi inflasi pada 45 kota yang diobservasi dalam penelitian ini. Sedangkan untuk hasil perhitungan kecepatan konvergensi menggunakan metode Augment Dicky-Fuller Test didapatkan hasil rata-rata kecepatan konvergensi nasional sebesar 5 bulan. Hasil perhitungan kecepatan konvergensi juga menunjukkan hasil bahwa 60% dari jumlah observasi memiliki kecepatan konvergensi yang lebih lambat dari rata-rata kecepatan konvergensi nasional.Kata Kunci: Konvergensi inflasi, Inflation Targeting, Otonomi daerah.
Strategi Komunikasi Penerapan Protokol Kesehatan Covid-19 di Masjid Agung Asy-Syuhada’ Pamekasan
Authors: Fauzuna Hafidlatul
Published: September 2022

This study aims to describe the communication strategy of the management of the Great Mosque of Asy-Syuhada' Pamekasan in implementing the Covid-19 health protocol and to describe maintaining distance when praying together in Islam during a pandemic. This research uses descriptive qualitative method. The result shows that the communication strategy used by the management of the Great Mosque of Asy-Syuhada' Pamekasan is in accordance with the components in the communication formulation in the Laswell concept, Who Says What in Which Channel to Whom With What Effect, which included communicator, message, media, communicant, and effect. The implementation of the health protocol is conveyed to the community or congregation by the mosque management in oral, written and electronic form and had an effect in which the congregation finally complied with the health protocol. Meanwhile, the legal case for keeping a distance in prayer is based on the letter Al-Baqarah verse 195, the hadith of the Prophet Muhammad SAW, and the rule of ushul fiqh. In this case, the case of keeping a distance in congregational prayers during the Covid-19 pandemic is allowed as an effort to prevent the transmission and spread of the virus.
Pengaruh Promosi di Media Sosial Instagram Terhadap Minat Beli Konsumen Ukir Pecah (Mahasiswa Universitas Trunojoyo Madura)
Authors: Wibowo Candra Wahyu , Kurriwati Nirma
Published: September 2022

This study aims to determine the effect of Instagram social media on buying intention in Ukir Pecah products among Trunojoyo University students, Madura. The method used in this research is to use a quantitative approach, the subjects in this study are students of Trunojoyo University, Madura. Sampling in this study using accidental sampling with a total of 99 respondents, and analysis using simple linear regression analysis. Sources of data in this study are primary data and secondary data. The data in this study were collected using a questionnaire technique, and after the data was collected, the researchers processed the data and the results from the calculated data, the authors drew conclusions. The results of this study are used to explain the influence of Instagram social media on consumer buying interest. The hypothesis in this-study is that-social-media Instagram has-a-significant-effect-on the Buying-Interest of Carving Broken consumers. It was found that the variable (X) namely social-media had a value of tcount ttable (20,0671,987). The-results of this study prove that the-independent variable, namely-the promotion in social-media-variable,-has-a-positive influence on-the dependent variable, namely the consumer buying interest variable.
Analisis Perbandingan Harga Saham, Volume Perdagangan, Dan Frekuensi Perdagangan Saham Sebelum Dan Sesudah Pengumuman Kasus Pertama Covid-19 di Indonesia (Event Study Pada Perusahaan Telekomunikasi Yang Terdaftar di BEI)
Authors: Sukma Fanny Dewi , Susandini Aprilina
Published: September 2022

This study aims to find out and compare the stock price, trading volume, and frequency of trading shares of telecommunication companies before and after the announcement of the first case of Covid-19 in Indonesia. The population in this study are companies that included in the Telecommunication Sub-Sector listed at IDX. The samples in this study used purposive sampling, where only 14 companies met the criteria. In this study, the data used is 30 days before and after the announcement of the first case of Covid-19 i n Indonesia. The hypothesis test used is Wilcoxon Signed Rank Test.The result showed that: 1) there is a significant differences in the stock price and trading volume of telecommunications companies before and after the announcement of the first case of Covid-19, 2) there is no significant difference in the frequency of trading shares of telecommunications companies before and after the announcement of the first case of Covid-19.
Pengaruh Keterlibatan Kerja Dan Kepuasan Kerja Terhadap Kinerja Karyawan PDAM Sumber Pocong Bangkalan Dengan Motivasi Sebagai Variabel Intervening
Authors: Hidayati Nurul , Safrizal Helmi Buyung Aulia
Published: September 2022

This study discusses about the effect job involvement, job satisfaction, empleyee performance and motivation of PDAM Sumber Pocong Bangkalan. The purposes of this study are to find out the effect job involvement and job satisfaction effect onemployee performance through motivation as an intervening variable. Ita use a quantitative approach population in this study 183 with 65 sample respondents, and used questionnaires in collecting data, using the multiple linear regression and path analyisis, the result showed that : 1) job involvement has a positive and significant effect on motivation. 2) job satisfaction has a positive and significant effect on motivation. 3) job involvement has a positive and significant effect on employee. 4) job satisfaction has a positive and significant effect on employee performance. 5) motivation has a positive and significant effect on employee performance 6) job involvement has a direct effect on employee performance without through the motivation. 7) job satisfaction has a direct effect on employee performance without through the motivation.
TOPONIMI PENAMAAN JALAN DI KECAMATAN LASALEPA KABUPATEN MUNA
Authors: Halfian Wa Ode , Hariyati Hariyati , Masri Fina Amalia
Published: September 2022

Penelitian ini dilatarbelakangi oleh banyaknya nama-nama jalan yang bermunculan di Kecamatan Lasalepa. Nama-nama tersebut sebagian terasa asing bahkan memilki makna yang unik dan lucu bagi masyarakat baik yang berada di daerah tersebut maupun dari luar daerah yang melewati jalan-jalan tersebut. Penamaan jalan-jalan tersebut tentunya tidak lepas dari latar belakang budaya masyarakat setempat. Oleh karena itu, Penelitian ini bertujuan untuk mendeskripsikan toponimi penamaan jalan yang ada di Kecamatan Lasalepa Kabupaten Muna. Teori yang digunakan dalam penelitian ini adalah teori semantik, antropolinguistik dan toponimi. Penelitian ini merupakan penelitian lapangan dangan menggunakan metode deskriptif kualitatif.  Teknik   pengumpulan   data   dalam   penelitian   ini   adalah   dengan menggunakan teknik wawancara, teknik catat, dan teknik rekam. Hasil penelitian ini menunjukkan bahwa Nama-nama jalan di Kecamatan Lasalepa sebagian besar tidak memiliki papan nama, namun masyarakatnya mampu mengetahui letak nama-nama jalan tersebut dengan baik, di mana mereka mampu menunjukkan arah dan lokasi dari nama-nama jalan tersebut tanpa adanya kekeliruan. Nama-nama jalan di Kecamatan Lasalepa Kabupaten Muna dilatarbelakangi oleh dua aspek penamaan, yaitu aspek perwujudan (Jalan Nambo, Jalan La Sari Muna, Jalan Wa Sandu-Sandu, Jalan Malaowaha, Jalan Tani, Jalan Bangunsari, dan Jalan Cendana) yang meliputi latar perairan dan Latar Permukaan Tanah atau Rupabumi (Geomorfologis), aspek kemasyarakatan   (Jalan   Kabuluha,   Jalan   Pogauha,   Jalan   Cumi-Cumi,   Jalan Lamodandu, Jalan Laode Oha, dan Jalan La Rengku) yang meliputi kebiasaan masyarakat dan tokoh masyarakat. Sistem tanda dalam toponimi nama-nama jalan di Kecamatan   Lasalepa   Kabupaten   Muna   meliputi   simbol,   gagasan,   dan   acuan (referent). Di mana simbol dan gagasan memiliki hubungan yang bersifat langsung. Artinya simbol dan gagasan tersebut merupakan pasangan otomatis. Sedangkan hubungan antara acuan dan simbol bersifat tidak langsung.
Pemanfaatan Analytical Hirarchy Process untuk Penentuan Karakteristik Combat Aircraft dalam Rangka Mendukung Industri Pertahanan Nasional
Authors: Afandi Ahmad , Soedianto Dwi , Bangun Edy Iwan
Published: September 2022

The Indonesian Air Force is the main combat tool in the use of force to defend the sovereignty and territorial integrity of the Unitary State of the Republic of Indonesia as a unit in order to achieve guarantees for the safety of the nation and state. Indonesia only relies on 33 F-16 AM, BM, C and D aircraft, which are more than 30 years old. Then 16 Sukhoi 27 and 30 aircraft with almost 20 years of age as the main fighter aircraft. The limited number of aircraft spare parts as well as the limited types and number of guided missiles also caused the combat readiness of the F16 and Sukhoi 27 and 30 aircraft to be not optimal. The F5 Tiger fighter has fallen out of service in recent years and there has been no replacement to date. Likewise, the Hawk 100/200 aircraft which are more than 25 years old. the obligation of the Ministry of Defense to plan the purchase of fighter aircraft that will operate until 2030 and 2040. This research will use the Analytical Hierarchy Process (AHP) method to determine the choice of Combat Aircraft with predetermined criteria with the alternative choice of Dassault Rafale fighter aircraft from France, the Su 35 Russian-made and US-made F-15 EX aircraft. The highest data processing results are Dassault Rafale 63.7%, Su 35 20.3% and F-15 EX 16%. The result of the Multirole Combat Aircraft selection is that the Dassaut Rafale is selected. with an Inconsistency value of 0.04. This shows that the alternative calculation is still within the inconsistency threshold, which is 0.1. With the election of Dassault Rafale, it is hoped that the Transfer of Technology with PT. Indonesian Aerospace in order to increase the capability of the Domestic Defense Industry, especially the Air Force. later PT DI will be directly involved in the Maintenance, Repair, and Overhaul (MRO) process, including the preparation of the supporting infrastructure
Sizing Optimization Using Genetic Algorithm to Achieve Minimal Offshore Structure
Authors: Syalsabila Ferdita , Prastianto Rudi Walujo , Rosyid Daniel Mohammad
Published: September 2022

Accelerating marginal field development must consider the economic factor. While the structural strength must remain capable and robust when subjected to environmental loads. To meet the desired objective in design phase, optimization is used. With the rapid growth of computing technology, the optimization method is developed as more advanced and reduced iteration time. However, the structural evaluation of jacket structure is a complex problem. The usual process of structure evaluation is through finite element analysis, and it is still time-consuming. Thus, surrogate models can evaluate the structure, lowering computational time. This study optimizes the jacket structure to get an affordable and robust minimal jacket structure. Sizing optimization will be performed on the jacket's leg and bracing thickness. For single-objective optimization, weight structure is considered the objective function, and multi-objective optimization adds production cost as the second objective function. The surrogate model uses the radial basis function to predict the relation between design variables and ultimate limit strength. The functions generated from the surrogate model will act as behaviour constraints in the optimization process. For consideration, X-type and V-type bracing configurations are compared. Different results were obtained from the single objective and multi-objective optimization process.
A NORMATIVE REVIEW OF THE SIMULTANEOUS GENERAL ELECTION AND REGIONAL HEAD ELECTION DELAY
Authors: Ansori Ansori , Fahmi Agung Ali , Mukhlish Mukhlish
Published: September 2022

A government system based on people's sovereignty can be called a democratic government system. Democracy itself is realized by a government based on representatives of the people who are democratically elected by means of general elections. General elections or elections are a logical consequence of a country that adheres to a democratic system, and democracy is a safe way to maintain control over the rule of law. article 3 of Law NO. 7 of 2017 concerning ELECTIONS states that ELECTIONS must be held based on the principles of being effective and efficient. Therefore, the separation of national elections and local elections is to represent the existence of this article. Simultaneous elections to be held in 2024, namely elections on a national and local scale, will bring various negative impacts. If the 2022 and 2023 Regional head elections are postponed and held in 2024, the Jakarta-centric issue is very dominant and local issues or agendas are sidelined. Meanwhile, the regulation related to the postponement of the Regional head election is contained in Article 201 paragraph (9), (10), and (11) of Law no. 1 of 2015 concerning Stipulation of Government Regulation into Law no. 1 of 2014 concerning the Election of Governors, Regents, and Mayors into Law.
LncRNA SNHG16 facilitates the liver metastasis of colorectal cancer by modulating circulating tumor cell epithelial-mesenchymal transition via a positive feedback loop with the YAP1/TEAD1 complex
Authors: Xiang Zhenxian , Huang Guoquan , Wu Haitao , He Qiuming , Yang Chaogang , Dou Rongzhang , Liu Qing , song jialing , Fang Yan , Wang Shuyi , xiong bin
Published: September 2022

Background: Circulating tumor cells (CTCs) are important precursors of colorectal cancer (CRC) metastasis. The epithelial-mesenchymal transition (EMT) process facilitates CTC invasion by allowing these cells to evade antimetastatic checkpoints to mediate distant metastasis. However, the molecular mechanism of CTC EMT remains largely unknown.
Results: Here, we studied the oncogenic long noncoding RNA (lncRNA) SNHG16, whose expression is correlated with advanced TNM stage, distant metastasis, and a poor prognosis in CRC patients. Furthermore, loss- and gain-of function revealed that SNHG16 promoted CRC proliferation, migration, invasion, EMT, mesenchymal-type CTC (MCTC) generation, and liver metastasis through YAP1. Mechanistically, SNHG16 could act as a miRNA sponge to sequester miR-195-5p on Ago2, thereby protecting YAP1 from repression. Moreover, YAP1 could combine with TEA domain transcription factor 1 (TEAD1) to form a YAP1/TEAD1 complex, which could in turn bind to the promoter of SNHG16 and regulate its transcription. Finally, we demonstrated that YAP1 significantly promoted tumor progression, and that SNHG16 rescued the effect of YAP1 on tumor progression.
Conclusion: Herein, we clarified a hitherto unexplored SNHG16-YAP1/TEAD1 positive feedback loop, which may be a candidate target for CRC treatment.
Diversified Substrate Implementation for the Design and Analysis of Microstrip Antenna for 5g Applications
Authors: M Ramya , G BalaMurugan , C Arunachalaperumal , S Suvitha
Published: September 2022

Now, wireless communication is in the 5G era. As the wireless communication technology grows rapidly, the devices are directly connected to the internet through wireless medium. This device requires high speed communications. In order to fulfill this requirement, researchers have to improve the bandwidth of transmitting and receiving antenna in the existing design. This paper gives the clear view of bandwidth enhancement by using Taconic TLX-9 substrate material of dielectric constant 2.5. With the help of CST Studio Suite Simulation Tool, a rectangular microstrip antenna was designed under the operating frequency of 3.5 GHz using three different substrate materials such as FR 4, Rogers RT 5870, and Taconic TLX-9. To improve the bandwidth, a proximity coupled feeding technique was used in this proposed model. An analysis was performed with this substrate material. This analysis concludes that the Taconic TLX-9 substrate material gives the bandwidth of 593.7 MHz at a return loss of -35dB. The maximum gain of 7.1dB was achieved under 3.5 GHz and also 6.823 was obtained under 3.5 GHz. The proposed antenna design can be used for 5G application (mid band). Further, the bandwidth, gain, directivity, return loss can be improved by introducing parasitic elements, arrays, SIW concepts etc.
Monitoring and prevention of urban fire based on Internet of Things (IoT) and NodeMCU
Authors: kuate Jean Marie fotso , Isaoura Bénite , Fotso Guy Phares Fotso , Nanfack Pélagie Flore Temgoua
Published: September 2022

Cloud computing has made it easier to access various forms of data and services through the Internet. coupling it to sensor networks makes it possible to significantly overcome the storage and computing performance limits of heterogeneous objects in the Internet of Things (IoT). In Cameroon, IoT is not yet very widespread. We use it here to monitor and prevent urban fires in real time, using a set of temperature, humidity, gas, flame and electrical power sensors that are integrated on NodeMCU, in view to detect fire starts and generate an alert. The data collected is stored and processed on ThingSpeak; a second analysis is carried out locally. After calibrating the sensors, we analyzed the data and carried out a correlation test to identify the most sensitive data for the alert system. The correlation coefficient of -0.721015 between temperature and humidity allowed us to maintain the system based on data quality.
Implementation of Energy-Efficient Auto Clustering Framework for Improving Quality of Service in IoT-enabled WSN Applications
Authors: P PARUTHI ILAM VAZHUTHI , S.P MANIKANDAN , A PRASANTH
Published: September 2022

In today’s world, emerging Internet of Things (IoT) technology have the most potential to extend the influence of the internet through IoT-enabled devices in futuristic fields such as smart healthcare, commercial, and industrial applications. Wireless Sensor Network (WSN) is utilized for sensing and communication processes over IoT-based applications. However, the battery energy of the sensor nodes is restricted in IoT-enabled WSN (IWSN) owing to its irreplaceable ability. Most of the existing clustering schemes lagged to mitigate the control packet overhead problem since it consumes extra energy for data computation, gathering, and forwarding tasks at any environmental conditions. In this paper, a novel Energy-Efficient Auto Clustering (EEAC) framework has been proposed to develop the effective IWSN model with enhanced quality of service. The EEAC framework comprises three phases such as zone formation, node classification, and auto clustering phases. The objective of the first phase is to significantly form the different zones by alleviating the hotspot problem. Subsequently, the fuzzy logic algorithm is employed in the second phase to classify the nodes as Master, Sub-Master, and member nodes. Finally, the third phase of the proposed framework will accomplish the auto clustering mechanism based on hop information received from the reported packet. The performance results evident that the proposed EEAC framework obtains a lesser energy consumption of 0.01J during dense network and the network lifetime is prolonged up to 48% when compared with existing state-of-the-art clustering models.
Vehicle detection on unstructured roads based on Transfer learning
Authors: Punagin Sahana , Iyer Nalini
Published: September 2022

Deep learning has seen tremendous progress in various fields. Autonomous Vehicle is one such field wherein the central branch of Computer Vision i.e Object detection serves as a key task. However, the performance of various algorithms depends on the scenarios where they are used. In this paper, an attempt is made to test the algorithms on unstructured roads with diverse data distributions. For this purpose, the single-stage network, YOLOv2 is demonstrated for vehicle detection on which transfer learning is applied. Along with the base model, the network uses Berkeley Deep Drive (BDD) dataset for knowledge transfer. Using BDD with YOLOv2 network, the model gives mAP of 72.4% and when the same model is tested in an unstructured environment using Indian Driving Dataset (IDD), it gives mAP of 56.76%.
Flexible MIMO Antennas for 5G Applications
Authors: kulkarni neeta premkumar , Bahadure Nilesh Bhaskarrao , Patil P. D. , Kulkarni Jayshri S.
Published: September 2022

5G is emerging as a next-generation technology which enhances capacity, provides very low latency, very high data rates, and good quality of service. For any 5G device to operate successfully, design and development of antenna plays very important role. Antenna should be compact in size, cost effective and should cover the desired 5G band with enhanced bandwidth, gain, and negligible radiation losses. The shrinking size of the futuristic and next-generation wireless devices will need miniaturized and tightly assembled antennas without affecting the performance. With the number of antennas increased in the MIMO system it will be difficult to meet the space constraint of next-generation devices. Also, with the innovation and ever-increasing demand for flexible electronic devices, there will be a need to design flexible antennas for such devices. Flexible antennas are having tremendous applications in Gateways and Routers, Wireless Access Points, High-speed HD streaming, Handheld Devices, Highcapacity MIMO networks for Public Transportation. This paper explains the concept of flexible antennas, the various types of substrates used for antenna fabrication. It also covers the various types of flexible MIMO antennas for 5G applications.
Primary User Spectrum Prediction Based on Supervised Model using Deep Radio
Authors: D sumithra sofia , A Shirly Edward
Published: September 2022

Sensing time plays an important role in Cognitive radio functionalities. The main approach of this paper is to predict the pattern of the primary user spectrum in order to reduce the battery power of the cognitive user in sensing the primary user spectrum continuously. We have developed a CNN-LSTN based model for predicting a traffic method with more accuracy. This method is relatively tested for different frequency bands of existing mobile operators using the deep radio.
A spatial beam property analyzer based on dispersive crystal diffraction for low-emittance X-ray light sources
Authors: Samadi Nazanin , shi Xianbo , Loch Cigdem Ozkan , Krempasky Juraj , Boege Michael , Chapman Dean , Stampanoni Marco
Published: September 2022

The advent of low-emittance synchrotron x-ray sources and free-electron lasers urges the development of novel diagnostic techniques for measuring and monitoring the spatial source properties, especially the source sizes. This work introduces an x-ray beam property analyzer based on a multi-crystal diffraction geometry, including a crystal-based monochromator and a Laue crystal in a dispersive setting to the monochromator. By measuring the flat beam and the transmitted beam profiles, the system can provide a simultaneous high-sensitivity characterization of the source size, divergence, position, and angle in the diffraction plane of the multi-crystal system. Detailed theoretical modeling predicts the system’s feasibility as a versatile characterization tool for monitoring the x-ray source and beam properties. The experimental validation was conducted at a bending magnet beamline at the Swiss Light Source by varying the machine parameters. A measurement sensitivity of less than 10% of a source size of around 12 μm is demonstrated. The proposed system offers a compact setup with simple x-ray optics and can also be utilized for monitoring the electron source.
Multi-source Information Fusion Based Attributed Heterogeneous Network Embedding
Authors: Zheng Susu , Guan Donghai , Yuan Weiwei
Published: September 2022

Attributed heterogeneous information network embedding is an emerging research topic in the field of network embedding. It can not only embed nodes with complex heterogeneous information into a low-dimensional space, but also preserve the rich attributed information of nodes. Existing works usually only use single-source information of node attributes or network structure, or simply use some shallow models to fuse multi-source information. These methods will lose the original network information and cannot make full use of the rich multi-source information in the attributed heterogeneous network, thus affecting the expression quality of the network embedding. To solve this problem, we propose a multi-source information fusion based attributed heterogeneous network embedding model (MAHE), which improves embedding performances through the deep fusion of heterogeneous structural information and node attribute information. The MAHE model first calculates the attribute similarity of nodes and the node structure similarity calculated by different meta-paths. Then the node attribute similarity matrix is weighted and fused with multiple heterogeneous similarity matrices to obtain multiple multi-source information similarity matrices. This aims to complement the attribute information with the semantic information of different meta-paths. The autoencoder is then used to learn the embeddings of nodes in each multi-source information similarity matrix. Finally, the attention mechanism is used to fuse these node embeddings to learn the importance of different multi-source embeddings.Experiments on three datasets show the superiority and effectiveness of the MAHE model.
Groundwater arsenic poisoning in a primary educational institution: health risks to school-going children
Authors: Rana Md. Sohel , Alam Md. Jahangir , Musa Md. Abu , Kumar Sazal , Rahman Md. Aminur
Published: September 2022

This study aimed to estimate arsenic (As) and iron (Fe) content in tubewell water (n = 58) in primary educational institutions and subsequently assess the health risks to school-going children. Results described that the As concentration ranged between 0.002 and 0.994 mg∙L-1 with an average value of 0.044 mg∙L-1; which exceeded the World Health Organization (WHO) provisional guideline value of 0.01 mg∙L-1. Similarly, the Fe content varied from 0.05 to 10 mg∙L-1 averaging to 2.84 mg∙L-1. Samples of 55.17 % contained a greater As concentration than 0.01 mg∙L-1 and 18.97% greater than Bangladesh drinking water quality (BDWQ) standardof 0.05 mg∙L-1, respectively. Meanwhile, 75.86 % of samples contained a higher Fe concentration than the maximum Bangladesh permissible limit of 1 mg∙L-1. Health risk assessment indicated that girls are more vulnerable than boys are. The average hazard quotients (HQs) for As intake through drinking water were 6.01 ± 17.85 and 7.41 ± 22.03 for boys and girls, respectively, implying non-carcinogenic health risks to both genders. The HQs for Fe intake were less than threshold value of 1 indicating no health issues may arise from Fe intake alone. However, consumption of As and Fe may trigger health risks to students as indicated by the hazard index (HI), which was higher than 1.The average cancer risk (CR) values for both boys (0.0027 ± 0.008) and girls (0.0033 ± 0.0099) exceeded the threshold limit of 10-6–10-4, suggesting a possibility of lifetime cancer risks to the school-going children. Consequently, school authorities should find alternative ways to ensure safe drinking water for school-going children to avoid possible cancer and non-cancer health risks through consumption of As-poisoning water.
Severe hypertriglyceridemia causing pseudo-acidosis: a case report
Authors: Gupta Sushan , Ojha Adarsha , Temitope Shodunke
Published: September 2022

Background: Pseudo hypobicarbonatemia is a rare phenomenon associated with spuriously low bicarbonate levels in the presence of elevated triglycerides (TG). TG's interfere with commonly used enzymatic assays in BMP, giving falsely low bicarbonate levels. It adds to the diagnostic dilemma and possible extensive workup to identify the cause. Previous case reports have used plasmapheresis in these settings. We report the successful use of insulin infusion in managing a case of pseudo-acidosis secondary to severely high TG levels.
Case presentation: Our patient was a 53-year-old female who presented with complaints of progressive fatigue. Her bicarbonate was 5 mmol/L on workup, anion gap was 30 mmol/L, with elevated TG levels. (5904 mg/dL). Arterial blood gas analysis showed normal pH (7.32) and normal calculated bicarbonate. (22.8mEq/L) Insulin infusion was started along with adding fenofibrate and atorvastatin. TG levels decreased progressively to 509 mg/dL with an associated normalization of bicarbonate levels and anion-gap acidosis on BMP. The patient was discharged on day 8 of her hospital stay.
Conclusion: Hyper TG can lead to pseudo hypobicarbonatemia, presenting as pseudo anion gap metabolic acidosis. It is essential to correlate the lab findings in the perspective of clinical findings to avoid over-testing and clinical misdiagnosis. In addition, these patients can be managed safely with insulin infusion in resource-limited settings.
Factors associated with medication interruption among outpatients’ severe mental illness patients exposed to coronavirus disease 2019
Authors: Jiao Jian , Ji Yuanyi , Ren Hua , Hao Yanni , Shen Xiaoling , Dong Zaiquan
Published: September 2022

Background.
In clinical, many patients with severe mental illness (SMI) have a relapse and deterioration in their illness during COVID-19, with an experienced medication interruption. This study aimed to investigate factors affecting medicine interruption in patients with SMI during the COVID-19 pandemic.
Methods.
Between 3 September and 7 October 2020, 2,077 patients with SMI participated in an online survey regarding their medication interruption during the COVID-19 outbreak. The questionnaire comprised six parts: basic demographic information, COVID-19 exposure, state of disease, medication compliance pre-COVID-19, medication interruption during COVID-19, and the specific impact and needs.
Results.
2,017 valid questionnaires were collected. Nearly 50% of patients with SMI have been affected to varying degrees in their lives and treatment. Among them, 74 patients stopped taking medicines for more than 14 days without a prescription. Binary logistic regression analysis showed that cohabitant exposure [OR = 26.629; 95% CI (3.293-215.323), p = 0.002], medication partial compliance and non-compliance pre-COVID-19 [OR = 11.109; 95% CI (6.093–20.251), p < 0.001; OR = 20.115; 95% CI (10.490-38.571), p < 0.001], and disease status [OR = 0.326; 95% CI (0.188–0.564), p < 0.001] were related to medication interruption. More than 50% of patients wanted help in taking medications, follow-up, and receiving more financial support and protective materials.
Conclusions.
Patients with a history of partial or non-medication compliance pre-COVID-19 and unstable disease state are more easily affect by epidemics and need extra attention should similar large-scale epidemics occur in future.
Evaluation of Two-stage designs of Phase 2 single-arm trials in glioblastoma: A systemic review
Authors: Yoo Wonsuk , Kim Seongho , Garcia Michael , Mehta Shwetal , Sanai Nader
Published: September 2022

Background: Due to economical and ethical reasons, the two-stage designs have been widely used for Phase 2 single-arm trials in oncology because the designs allow us to stop the trial early if the proposed treatment is likely to be ineffective. Nonetheless, none has examined the usage for published articles that had applied the two-stage designs in Phase 2 single-arm trials in brain tumor. A complete systemic review and discussions for overcoming design issues might be important to better understand why oncology trials have shown low success rates in early phase trials.
Methods: We systemically reviewed published single-arm two-stage Phase 2 trials for patients with glioblastoma and high-grade gliomas (including newly diagnosed or recurrent). We also sought to understand how these two-stage trials have been implemented and discuss potential design issues which we hope will be helpful for investigators who work with Phase 2 clinical trials in rare and high-risk cancer studies including Neuro-Oncology. The systematic review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-statement. Searches were conducted using the electronic database of PubMed, Google Scholar and ClinicalTrials.gov for potentially eligible publications from inception by two independent researchers up to May 26, 2022. The followings were key words for the literature search as index terms or free-text words: “phase II trials”, “glioblastoma”, and “two-stage design”. We extracted disease type and setting, population, therapeutic drug, primary endpoint, input parameters and sample size results from two-stage designs, and historical control reference.
Results: Among examined 29 trials, 12 trails (41%) appropriately provided key input parameters and sample size results from two-stage design implementation. Among appropriately implemented 12 trials, discouragingly only 3 trials (10%) explained the reference information of historical control rates.
Conclusions: Appropriate selection on primary endpoint, transparency of historical control and experimental rates, right implementation for two-stage design and sample size calculation, potential incorporation of adaptive designs, and utilization of Phase 0 paradigm might help overcoming the challenges on glioblastoma therapeutic trials in Phase 2 trials.
Disruption of the developmental programming of the gonad of the broad snouted caiman (Caiman latirostris) after in ovo exposure to atrazine.
Authors: Canesini Guillermina , Galoppo Germán Hugo , Tavalieri Yamil Ezequiel , Lazzarino Gisela Paola , Stoker Cora , Luque Enrique Hugo , Ramos Jorge Guillermo , Muñoz-de-Toro Mónica Milagros
Published: September 2022

Environmental exposure to agrochemicals during early stages of development can induce subtle alterations that could permanently affect normal physiology. Previously, we reported that in ovo exposure to atrazine (ATZ) disrupts testicular histoarchitecture in postnatal caimans (Caiman latirostris). To assess whether such alterations are the result of disruption of gonadal developmental programming, this study aimed to evaluate the expression of histofunctional biomarkers (VASA, ER, PR, PCNA, and aromatase) and genes involved in gonadal development and differentiation (amh, sox-9, sf-1 and cyp19-a1) in the gonads of male and female caiman embryos and to assess the effect of ATZ exposure on these biomarkers and genes in the gonads of male embryos. Our results suggest that amh, aromatase and sox-9 play a role in sex determination and gonadal differentiation. In male caiman embryos, ATZ exposure increased aromatase expression and altered the temporal expression pattern of amh and sox-9 evidencing an ATZ-induced disruption of gonadal developmental programming. Since the effects of ATZ are consistent across all vertebrate classes, the ATZ-mediated disruptive effects here observed could be present in other vertebrate species.
Potential Role of Artemisinin And Its Derivatives In The Treatment of Age-related Macular Degeneration
Authors: Liu Chun , Ma Jie , Mo Ya , Duan Junguo
Published: September 2022

Age-related macular degeneration (AMD) is an important cause of visual impairment and even blindness in the elderly. At present, the treatment of AMD mainly focuses on the treatment of Neovascular AMD (nvAMD), by repeatedly injecting anti-vascular endothelial growth factor (anti-VEGF) drugs into the vitreous. Although anti-VEGF drugs are landmark treatment options in the field of nvAMD treatment, multiple injections may cause some patients to respond poorly or even non-responsively and may develop progressive fibrosis. Artemisinin and its derivatives were initially used as antimalarial treatments. In recent years, the role of artemisinin and its derivatives in AMD has attracted great attention. Artemisinin treatment can not only effectively protect pigment epithelial cells in AMD from oxidative damage, reverse pigment epithelial cell mitochondrial dysfunction and anti-angiogenesis, but also effectively reduce pre-corneal injury caused by vitreous injection of anti-VEGF through microparticle drugs (carrying artemisinin). Many experiments have confirmed the therapeutic effect of artemisinin and its derivatives on AMD, but no article has systematically demonstrated the special role of artemisinin in the treatment of AMD. This article reviews the potential therapeutic effects and mechanisms of artemisinin and its derivatives in AMD to provide references for subsequent related studies.
Impact of microbial genome completeness on functional metagenomics
Authors: Eisenhofer Raphael , Odriozola Iñaki , Alberdi Antton
Published: September 2022

Inferring the functional capabilities of bacteria from metagenome-assembled genomes (MAGs) is becoming a central process in microbiology. Here we show that the completeness of genomes has a significant impact on the recovered functional signal, spanning all domains of metabolic functions. We identify factors that affect this relationship between genome completeness and function fullness, and provide baseline knowledge to guide efforts to correct for this new-found bias in functional metagenomic analyses.
Multi objectives Edge Server Placement in Mobile Edge computing Using Trees Social Relations Optimization Algorithm and DVFS technique
Authors: asghari ali , Azgomi Hossein , Zoraghchian Ali Abbas
Published: September 2022

The advent of fifth-generation(5G) telecommunication technology and the rapid growth of smart mobile equipment have led to many processing demands in this area. Many mobile applications developed with this technological growth. In most cases, the services required by mobile cloud users are offered online. The high volume of processes such as the Internet of Things, online games, electronic education, and e-commerce, which are processing-oriented, consumes a large amount of energy. The limited power of mobile equipment and their battery capacity causes some users' data and applications to be offloaded on network edge servers. Proper placement of mobile cloud resources has an important impact on their efficiency and energy consumption. The appropriate resource placement model can reduce latency and improve energy consumption. Because of the large number of mobile servers, finding the best geographical placement of all resources is an NP-Hard problem, so researchers have introduced some optimization methods for the problem solution. Parallelization methods can improve the scalability of the resource placement problem and reduce the time complexity of finding the optimal solution. In the proposed method, a novel multi-objective edge server placement algorithm, using the trees social relations optimization algorithm(TSR) and the DVFS(dynamic voltage and frequency scaling) technique (MSP-TD), has been introduced for optimal placement of edge servers to extend the network coverage. The simulation results show that our proposed model leads to less latency and energy consumption reduction than some state-of-the-art and similar algorithms.
Targeted dual base editing with Campylobacter jejuni Cas9 by a single AAV-mediated delivery
Authors: Kim Yongsub , Kweon Jiyein , Jang An-Hee , Kwon Eunji , Kim Ungi , Shin Ha Rim , See Jieun , Jang Gayoung , Lee Chaeyeon , Koo Taeyoung , Kim Seokjoong
Published: September 2022

Various CRISPR-Cas9 orthologues are used in genome engineering. One of the smallest Cas9 orthologues is cjCas9 derived from Campylobacter jejuni, which is a highly specific genome editing tool. Here, we developed cjCas9-based base editors including a cytosine base editor (cjCBEmax) and an adenine base editor (cjABE8e) that can successfully induce endogenous base substitutions by up to 91.2% at the HPDgene in HEK293T cells. Analysis of the base editing efficiency of 13 endogenous target sites showed that the active windows of cjCBEmax and cjABE8e are wider than those of spCas9-based base editors and that their specificities are slightly lower than that of cjCas9. Importantly, engineered cjCas9 and gRNA scaffold can improve the base editing efficiency of cjABE8e by up to 6.4-fold at the HIF1A gene in HEK293T cells. Due to its small size, cjABE8e can be packaged in a single adeno-associated virus vector with two tandem arrays of gRNAs, and the delivery of the resulting AAV could introduce base substitutions at endogenous ANGPT2 and HPD target sites. Overall, our findings have expanded the potential of the use of base editors for in vivo or ex vivo therapeutic approaches.
Is planting sorghum as summer catch crop a promising strategy to enhance subsequent eggplant yield and reduce nitrate accumulation in protected-field vegetable system？
Authors: Ma Yan , Kang Lingyun , Li Yanqing , Zhang Xinjun , Cardenas Laura M. , Chen Qing
Published: September 2022

Purpose
Summer catch crop (CC) has been introduced into the vegetable rotating system in protected fields to reduce nitrogen (N) losses through crop uptake and residual N immobilization. However, the effects of sorghum with biological nitrification inhibition (BNI) capacity as a CC on soil N dynamics and subsequent crop yield remain unclear.
Methods
In the two-year protected field experiment, the comprehensive effects of sorghum as CC on subsequent eggplant yield, soil mineral N dynamics, ammonia-oxidizing archaea (AOA) and bacteria (AOB) were determined, in comparison to the sweet corn and fallow treatments.
Results
Compared to the fallow treatment, sweet corn and sorghum as CC increased subsequent eggplant yield by 12.22% (not significantly) and 18.94%-24.88% (significantly), respectively. CC planting reduced soil nitrate (NO3--N) accumulation during the summer fallow season. Sorghum planting could significantly maintain higher level of ammonium (NH4+-N) concentration during the summer fallow season and the first month of succeeding over-winter season. In addition, sorghum planting reduced soil nitrifying potential, which could be partially attributed to the decreased amoA gene abundance of AOA at the 0–30 and 30–60 cm soil layers and AOB at 0–30 cm soil layer. However, similar results were not observed while planting sweet corn.
Conclusion
We conclude that planting sorghum with BNI capacity in the summer fallow season is a promising strategy to retain soil NH4+-N, reduce soil NO3--N accumulation, and enhance subsequent eggplant yield.