bluuebunny/crossref_metadata_2025 huggingface dataset:
Cultural Cognition and Analytical Methods of Chinese and Korean Envoys in Ming Dynasty Based on Big Data Analysis Technology
Authors: Wang Ke , Tang Lulu
Published: September 2022

During the Ming Dynasty, China and Korea exchanged frequently and recorded a large amount of written information, which is of great value for understanding the culture of that time. The large amount of data makes it difficult to conduct quantitative analysis by researchers, which makes the analysis limited. This paper carries out a research on the cognition and analysis method of Chinese and Korean envoys to foreign cultures in Ming Dynasty based on big data analysis technology. Based on the literature research, this paper determines the ontology model establishment method to efficiently detect the written records of Chinese and Korean envoys in Ming Dynasty. The established ontology model and the improved clustering analysis method can improve the efficiency of data detection, reduce the error of data detection, and provide data basis for the research of this paper. According to the technology of big data analysis, this paper analyzes the focus and status class of Chinese and Korean envoys in Ming Dynasty and analyzes cognition of the Chinese and Korean envoys for the foreign culture. The results show that the envoys of the Chinese and Korean pay different attention to the foreign culture due to their different cognition of the foreign culture, compared with Ming Dynasty envoys, Korean envoys paid 15.3 percent less attention to geography, 19.7 percent more to history, 11.7 percent more to people, and 16 percent less to customs. This reflects the two envoys’ different perceptions of the foreign culture. And the status class of the envoys exacerbates this difference. In the early Ming Dynasty, the creative diversity of Ming envoys was far lower than that of Korean envoys. As time went by, the creative diversity of Ming envoys increased. The results provide support for further understanding of Chinese and Korean culture and their relationship in Ming Dynasty.
Network Pharmacology and Molecular Docking Analyses Unveil the Mechanisms of Yiguanjian Decoction against Parkinson’s Disease from Inner/Outer Brain Perspective
Authors: Shen Zhongqi , Yu Meng , Zhang Shaozhi
Published: September 2022

Objective. This study aims to explore the pharmacodynamic mechanism of Yiguanjian (YGJ) decoction against Parkinson’s disease (PD) through integrating the central nervous (inner brain) and peripheral system (outer brain) relationship spectrum. Methods. The active components of YGJ were achieved from the TCMSP, TCMID, and TCM@Taiwan databases. The blood‐brain barrier (BBB) permeability of the active components along with their corresponding targets was evaluated utilizing the existing website, namely, SwissADME and SwissTargetPrediction. The targets of PD were determined through database retrieval. The interaction network was constructed upon the STRING database, followed by the visualization using Cytoscape software. Then, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses on potential targets. Finally, the molecular docking approach was employed to assess the binding affinity between key components and key targets. Results. Overall, we identified 79 active components, 128 potential targets of YGJ, and 97 potential targets of YGJ‐BBB potentially suitable for the treatment of PD. GO and KEGG analyses showed that the YGJ treatment of PD mainly relied on PI3K‐Akt pathway while the YGJ‐BBB was mostly involved in endocrine resistance. The molecular docking results displayed high affinity between multiple compounds and targets in accordance with previous observations. Conclusions. Our study unveiled the potential mechanisms of YGJ against PD from a systemic perspective: (1) for the YGJ, they have potential exerting effects on the peripheral system and inhibiting neuronal apoptosis through regulating the PI3K‐Akt pathway; (2) for the YGJ‐BBB, they can directly modulate endocrine resistance of the central nervous and holistically enhance body resistance to PD along with YGJ on PI3K‐Akt pathway.
Identification of Downregulated Exosome-Associated Gene ENPP1 as a Novel Lipid Metabolism and Immune-Associated Biomarker for Hepatocellular Carcinoma
Authors: Li Zhilan. , He Qingchun. , Peng Jinwu. , Yan Yuanliang. , Fu Chencheng.
Published: September 2022

Exosome plays an important role in the occurrence and development of tumors, such as hepatocellular carcinoma (LIHC). However, the functions and mechanisms of exosome-associated molecules in LIHC are still underexplored. Here, we investigated the role of the exosome-related gene ENPP1 in LIHC. Comprehensive bioinformatics from multiple databases revealed that ENPP1 was significantly downregulated in LIHC tissues. The patients with downregulated ENPP1 displayed a poor prognosis. Immunohistochemistry (IHC) was used to further confirm the downregulated ENPP1 in LIHC tissues. In addition, the coexpression network of ENPP1 was also explored to understand its roles in the underlying signaling pathways, including fatty acid degradation and the PPAR signaling pathway. Simultaneously, GSEA analysis indicated the potential roles of ENPP1 in the lipid metabolism-associated signaling pathways in the pathogenesis of LIHC, including fatty acid metabolism, fatty acid synthesis, and so on. Finally, immunological analysis indicated that ENPP1 might also be involved in multiple immune-related features, including immunoinhibitors, immunostimulators, and chemokines. Taken together, these findings could enhance our understanding of ENPP1 in LIHC pathogenesis and immune response and provide a new target for ENPP1-related immunotherapy in clinical treatment.
Surgical Treatment of Hand and Foot Gout Stone and Influence Factors on Prognosis
Authors: Qiu Xudong , Zhao Bo , Du Xingxu , Jin Shuo , Zhao Weiyan
Published: September 2022

Purpose. To explore the technique of surgical treatment of hand and foot gout stone by using 3D CT reconstruction images and influence factors on prognosis. Method. 48 cases of hand and foot gout were treated surgically and retrospective analyzed. Before operation, we used 3D CT reconstruction images to check the accurate site and amount of uric acid (white chalk foam) deposition. Different surgical methods were applied depending on the different deposition site of urine acid stone. The frequency of gout attack and blood uric acid was compared before and after surgery. Patients were followed up to observe the recovery and recurrence and then analyzed the reason of unsuccessful healing. Result. Sutures were removed 2 weeks after operation in all cases. The frequency of gout attack and blood uric acid of patients 3 months after operation was lower than those before operation, and the differences were statistically significant. Follow-up ranged from 1 to 3 years, with an average of 1.8 years. Three cases were not followed up. The remaining 45 cases were healed in the first stage. 40 cases had improved joint function, increased range of motion, and relieved discomfort after movement. 5 cases had no improvement in joint function after operation, and 3 of them had gout stone recurrence (nonoperative area) and were treated by second hospital operation. Conclusion. Surgical treatment of gout stone in hand and foot under the guidance of three-dimensional CT reconstruction image can effectively alleviate the local symptoms of gout stone and improve the function of hand and foot. Deep tissue can be thoroughly washed by the pressure of pulse gun after resection of the lesion, which can reduce the incidence of gout stone. Malnutrition, hypoproteinemia, and residual urine acid in the wound are the main reasons for unsuccessful healing.
[Retracted] Spatiotemporal Variation of Surface Sediment Quality in the Xiamen Sea Area, China
Authors: Fu Shifeng , Wu Haiyan , Chen Hongzhe , Cai Xiaoqiong , Pan Xiang , Wu Yibiao
Published: September 2022

The study analyzes the survey data on the surface sediments in 355 stations in Xiamen Sea area during 2004‐2006, 2007‐2009, 2010‐2013, and 2014‐2016. The result finds that contents of TOC, sulfide, and oils in the surface sediments were generally low but showed significant spatial differences (p < 0.05) in most cases, with TOC in the West Sea area (WS) staying significantly higher than other sea areas. Xiamen Sea area suffered universal heavy metal pollution mainly from Cu and Zn for years in the WS, the Jiulong River Estuary (JE), and the East Sea area (ES), and the heavy metal pollution index (HPI) exhibited significant spatial differences across the four periods (p < 0.05). With the source of heavy metals in the WS being mainly related to human activities, Cu and Zn were related to the development of port shipping and Pb to aquaculture. The heavy metal pollution in JE was mainly related to the input of rivers emptying into the sea. The high Cu content in the ES was related to the direct discharge of massive domestic sewage into the sea at the time. From 2004 to 2016, the potential ecological risks of heavy metals in Xiamen Sea area stayed low.
Prediction of Risk Takers in Arterial Hypertension Patients with Data Mining Application
Authors: Alhazmi Lamia , Alassery Fawaz
Published: September 2022

Hyper arterial pressure (HAP) is a disease that kills silently because it does not produce symptoms in the early stages, making it difficult to diagnose. When it is detected, its treatment is not accessible to everyone, which affects the disease’s long-term development. Hypertension affects a large portion of the Iraqi population. In the current research paper, we have discussed how data mining can be applied to identify the status of the risk factors that affect arterial hypertension due to I10-I15 causes, evaluating the context variables disability, overwork, high-risk pregnancy, stress, high diets, and poor nutrition in the population between 50 and 64 years in the city of Baghdad. It is possible to see how data mining in large volumes of health data can generate new knowledge and thus uncover hidden patterns in the data through the development of this research. Attributes directly linked to disease prevalence can be found in data from Baghdad, Iraq, even if they are not directly linked to a specific cause. This shows that some variables are transversal to the development of the disease regardless of its categorization. Cluster analysis revealed that, even though these diseases are categorized as having different causes, they have a degree of incorrect classification of 40.71% because they present attributes with a similar behavior transversal to the disease and not the disease-specific cause for which it is categorized.
A Mixed-Integer Solution for TDOA Based Direct Positioning of Digital Modulation Signal
Authors: Yang Zeyu , Wang Ding , Ren Xiukun , Nie Fuquan , Yang Bin
Published: September 2022

This paper proposes a direct position determination (DPD) method for a digital modulation signal based on time difference of arrival (TDOA) measurements. Unlike the two-step positioning process, the measurements are used to directly estimate the source position. Fully utilizing information in a transmitted waveform can improve the accuracy of source localization in a single-step method. Based on maximum likelihood (ML) estimates, when the digital modulation scheme is known to the location system, an alternating iterative DPD method is developed to locate the emitter. The objective function of the proposed algorithm takes into account the source position and transmitted symbol sequence, which makes it a mixed-integer optimization problem. In particular, ML sequence estimation is adopted and the complex envelope is restored using a genetic algorithm. Then, based on Newton’s method, an alternating iterative algorithm is proposed to update the position and symbol sequence results. Compared with the existing DPD method, the proposed algorithm gives more accurate location results for unknown waveforms. In addition, the proposed algorithm can reach the Cramér-Rao bound (CRB) for known signal waveforms, as verified using comprehensive simulations.
Simple Analytical Method on the Determination of Dexamethasone in Herbal Medicine
Authors: Pratiwi Rimadani , Rahmawaty Adira , Hasanah Aliya Nur
Published: September 2022

Chemical drugs have been added to some of the traditional herbal medicine to enhance the therapeutic effect. One of them is dexamethasone which is added in herbal pain relief. To determine the content of dexamethasone in herbal medicine, a quantitative analytical method was developed with the reaction of the formation of a dexamethasone-hydroxylamine complex with fluoranil which was measured by UV-Vis spectrophotometry. Under optimized conditions, the performance of this system to analyze dexamethasone exhibited a good analytical response. The correlation coefficient was (R2) of 0.9965 from a concentration of 1–40 g/mL, LOD, and LOQ of 0.21 μg/mL and 0.64 μg/mL, % recovery for concentrations of 80%,100%, and 120%, are 100.14% ± 0.58; 98.35% ± 1.19; and 99.00% ± 1.18, respectively; and %RSD is 0.75%. The sixteen herbal medicine samples were analyzed to confirm the application of this method. The result showed six samples confirmed containing dexamethasone with levels ranging from 7.44 to 21.61 μg/mL and confirmed with HPLC data. The UV-Vis spectrophotometry method is simple and effective for dexamethasone analysis in herbal medicine.
Optimal Weak Type Estimates for the P‐ADIC Hardy Type Operators on Higher‐Dimensional Product Spaces
Authors: Wei Junchao
Published: September 2022

In this paper, we introduce the fractional p‐adic Hardy operators and its conjugate operators and obtain its optimal weak type estimates on the p‐adic Lebesgue product spaces.
A Four-Gene Signature Associated with Radioresistance in Head and Neck Squamous Cell Carcinoma Identified by Text Mining and Data Analysis
Authors: Zhang Yongqian , Wang Hongmin , Wang Feifei , Ma Wenhua , Li Na , Bo Changwen , Zhao YingChun , He Li , Liu Ming
Published: September 2022

Purpose. Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer globally, and radiotherapy plays a crucial part in its treatment. This study was designed to identify potential genes related to radiation resistance in HNSCC. Method. We first used text mining to obtain common genes related to radiotherapy resistance and HNSCC in published articles. Functional enrichment analyses were conducted to identify the significantly enriched pathways and genes. Protein and protein interactions were performed, and the most significant gene modules were determined; then, genes in the gene modules were validated at transcriptional levels and overall survival. Gene set variation analysis (GSVA) score was calculated, and the association between GSVA score and survival/pathway was estimated. Immune cell infiltration, methylation, and genetic alteration analysis of these genes was conducted in HNSCC patients. Finally, potential sensitive anticancer drugs related to target genes were obtained. Result. We identified 583 common genes through text mining. After further validation, a four-gene signature (EPHB2, SPP1, SERPINE1, and VEGFC) was constructed. The patients with higher GSVA scores have a worse prognosis than those with lower GSVA scores. Differences in methylation of these four genes in HNSCC tumor tissue and normal tissue were compared, with higher methylation levels of EBPH2 and SPP1 in normal tissue and higher methylation levels of SERPINE1 in the tumor. Immune cell infiltration revealed that the increased expression of these genes was closely related to the infiltration level of CD4+ T cell, neutrophil, macrophage, and dendritic cell. Thirty drugs, including 22 positively and eight negatively correlated drugs that most correlated with related genes, were available for treating HNSCC. Conclusion. In this study, we identified four potential genes as well as corresponding drugs that might be related to radioresistance in HNSCC patients. These candidate genes may provide a promising avenue to further elevate radiotherapy efficacy.
Alpha-Particle Generation from H-11B Fusion Initiated by Laser-Accelerated Boron Ions
Authors: Kong Defeng , Xu Shirui , Shou Yinren , Gao Ying , Mei Zhusong , Pan Zhuo , Liu Zhipeng , Cao Zhengxuan , Liang Yulan , Peng Ziyang , Wang Pengjie , Luo Di , Li Yang , Li Zhi , Xie Huasheng , Zhang Guoqiang , Luo Wen , Zhao Jiarui , Chen Shiyou , Geng Yixing , Zhao Yanying , Xue Jianming , Yan Xueqing , Ma Wenjun , Belloni Fabio
Published: September 2022

Here, we report the generation of MeV alpha-particles from H-11B fusion initiated by laser-accelerated boron ions. Boron ions with maximum energy of 6 MeV and fluence of 109/MeV/sr@5 MeV were generated from 60 nm-thick self-supporting boron nanofoils irradiated by 1 J femtosecond pulses at an intensity of 1019W/cm2. By bombarding secondary hydrogenous targets with the boron ions, 3 × 105/sr alpha-particles from H-11B fusion were registered, which is consistent with the theoretical yield calculated from the measured boron energy spectra. Our results demonstrated an alternative way toward ultrashort MeV alpha-particle sources employing compact femtosecond lasers. The ion acceleration and product measurement scheme are referential for the studies on the ion stopping power and cross section of the H-11B reaction in solid or plasma.
The PDGF Family Is Associated with Activated Tumor Stroma and Poor Prognosis in Ovarian Cancer
Authors: Li Jiajia , Zhi Xiuling , Sun Yating , Chen Mo , Yao Liangqing
Published: September 2022

The initiation and progression of cancer depend on the genetic alterations inherent in cancer cells, coupled with the mutual interplay of cancer cells with the surrounding tumor stroma. The platelet-derived growth factor (PDGF) family, as a mesenchymal growth factor, was involved in tumor progression by affecting the surrounding tumor stroma in some cancer types. However, the association of the PDGF family with the ovarian cancer stroma remains elusive. In our study, we first explored the expression pattern of the PDGF family using RNA expression profiles from public databases. We found that the PDGF family was highly expressed in tumor stroma compared with the corresponding epithelial components of ovarian cancer. In particular, PDGF receptors were weakly expressed in ovarian cancer tissues compared with the respective normal tissues; even in tumor mass, PDGF receptors were predominantly expressed by tumor stroma rather than ovarian cancer cells. Importantly, functional enrichment analyses and correlation analyses revealed that the PDGF family was strongly associated with activated stromal scores in ovarian cancer, including higher stromal scores, enriched pathways related to the extracellular matrix (ECM) organization and remodeling, elevated cancer-associated fibroblasts (CAFs) infiltration, and increased tumor-associated macrophages (TAMs) infiltration, especially macrophage M2. Besides, the positive correlations of the PDGF family with CAFs infiltration and macrophage M2 infiltration were observed in other various cancer types. Of note, the PDGF family was also involved in tumor progression-related pathways, such as transforming growth factor β (TGF-β) signaling, epithelial-mesenchymal transition (EMT), angiogenesis, and phosphatidylinositol 3-kinase-Akt (PI3K-Akt) signaling. Higher expressions of PDGF receptors were also observed in ovarian cancer patients with venous or lymphatic invasion. Furthermore, we uncovered the prognostic prediction of the PDGF family in ovarian cancer and constructed a PDGF family-based risk prognosis model with a hazard ratio of 1.932 (

95
%
confidence
 
interval
 

CI

=
1.27
–
2.95

) and

P

value < 0.01 (

AUC
=
0.782

, 0.752 for 1 year and 2 years, respectively). Taken together, we demonstrated that ovarian cancers with high PDGF family expression biologically exhibit malignant progression behaviors as well as poor clinical survival, which is attributed to the activated tumor stroma in ovarian cancer.
The Ottawa Decision‐Making Supportive Framework‐Based Nursing Care in the Outcome of Patients with Chronic Heart Failure
Authors: Teng Yufang , Liu Tingting , Li Xiaxia , Feng Weilu , Wu Yanping , Su Shan , Guan Xiaobo
Published: September 2022

Objective. To examine the psychological, compliance, and prognostic impact of care based on the Ottawa Decision Support Framework on patients with chronic heart failure. Methods. The medical profiles of 80 individuals with permanent heart failure from January 2020 to January 2021 were retrospectively analyzed. The care was provided in the framework of Ottawa Decision Support alongside the clinical standard of care. The self‐assessment anxiety scale (SAS), Frankel treatment adherence scale, Minnesota quality of life questionnaire for heart failure, self‐care competence scale (ESCA), complication rates, and readmission rates were compared prior to and postcare. Results. Following three‐month nursing care, the score of the SAS scale was remarkably fewer, and the difference was statistically significant (P < 0.05). Three months of care later, the scores on the Frank Scale were substantially superior to those before care, and the difference was statistically significant (P < 0.05). Aftercare, the Minnesota quality of life questionnaire for heart failure was clearly inferior to precare, and the difference was statistically significant (P < 0.05). The ESCA scale scores were found to be considerably more favorable after three months of care than before care, and the difference was statistically significant (P < 0.05). After nursing care, one arrhythmia (1.25%) and one pulmonary infection (1.25%) were noted, and the difference was statistically significant (P < 0.05). The prevalence of complications was 2.50%, and the difference was statistically significant (P < 0.05). Three cases were readmitted for recurrent chronic heart failure, which was a 2.75% readmission rate. Conclusion. Continuous nursing based on the Ottawa Decision Support Framework has significant application value in an anxiety state, treatment compliance, and prognosis of patients with chronic heart failure, which can more effectively reduce patients’ anxiety and the incidence of complications and readmission rate, in the meanwhile, effectively improve treatment compliance, quality of life, self‐care ability, and prognosis, which is worthy of clinical application.
Screening of Sepsis Biomarkers Based on Bioinformatics Data Analysis
Authors: Liang Guibin , Li Jiuang , Pu Shiqian , He Zhihui
Published: September 2022

Background and objectives. Sepsis is a life-threatening organ dysfunction caused by the imbalance of the body’s response to infection. Delay in sepsis diagnosis has become a primary cause of patient death. This study aims to identify potential biomarkers of sepsis based on bioinformatics data analysis, so as to provide new gene biomarkers for the diagnosis and treatment of sepsis. Methods. Gene expression profiles of GSE13904, GSE26378, GSE26440, GSE65682, and GSE69528 were obtained from the National Center for Biotechnology Information (NCBI). The differentially expressed genes (DEGs) were searched using limma software package. Gene Ontology (GO) functional analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and protein-protein interaction (PPI) network analysis were performed to elucidate molecular mechanisms of DEGs and screen hub genes. Results. A total of 108 DEGs were identified in the study, of which 67 were upregulated and 41 were downregulated. 15 superlative diagnostic biomarkers (CCL5, CCR7, CD2, CD27, CD274, CD3D, GNLY, GZMA, GZMH, GZMK, IL2RB, IL7R, ITK, KLRB1, and PRF1) for sepsis were identified by bioinformatics analysis. Conclusion. 15 hub genes (CCL5, CCR7, CD2, CD27, CD274, CD3D, GNLY, GZMA, GZMH, GZMK, IL2RB, IL7R, ITK, KLRB1, and PRF1) have been elucidated in this study, and these biomarkers may be helpful in the diagnosis and therapy of patients with sepsis.
Choice and Influence of Return Policy and Remanufacture in a Dual‐Channel Supply Chain
Authors: Shi Song , Liu Guilin , Shi Ping
Published: September 2022

To investigate the choice of return strategy and its impact on a dual‐channel supply chain, a game model is constructed to analyze the equilibrium outcomes of five scenarios: no returns allowed, refunds without returns, returns allowed but no return shipping insurance, returns allowed and return shipping insurance purchased by the manufacturer, and returns allowed and return shipping insurance purchased by the consumer. The study found that manufacturers offering refund policies generate more sales in the direct online channel, while retailers choose to reduce the retail price of their products. It is important to note that price reductions by retailers have a very limited effect and do not lead to an increase in sales in the retail channel. Manufacturers offering refund policies will inevitably infringe on retailers’ profits, and the variability of manufacturers’ profits depends on the residual value of returned products. Manufacturers should decide whether to offer a refund policy in online direct sales channels based on the residual value of the returned product; otherwise, the action would be detrimental to themselves. The price of direct online sales is the same whether the manufacturer buys the return shipping insurance or the consumer buys the return shipping insurance, but when the return shipping insurance is bought by the consumer, sales are higher in the direct online channel and lower in the retail channel. When the return shipping cost reimbursement received after purchasing return shipping insurance is low, it should be purchased by the manufacturer, and when the return shipping cost reimbursement received after purchasing return shipping insurance is high, it will be better for the consumer to purchase return shipping insurance.
Optimal Valuation of Retailer Equity Financing Based on Gambling Agreements in Centralized Supply Chain
Authors: Wang Liang , Wang Guiru
Published: September 2022

This paper explores the issue of optimal valuation of retailer equity financing based on gambling agreements in a centralized supply chain. Firstly, the betting target settings are classified into three cases: high, medium, and low. Secondly, the optimal valuation models for retailer equity financing in a centralized supply chain without and with introducing a gambling agreement are constructed separately. Finally, this paper clarifies the relationships among factors such as the betting transfer share ratio, ordering price, and optimal valuation level through simulation analysis. The results illustrate the following: (i) There is always an only optimal valuation level and optimal effort level that makes the retailer and supplier might reach an equity financing agreement. (ii) When the betting target is set too high, the betting transfer share ratio varies in the same direction as the optimal valuation level and the opposite direction as the optimal effort level. (iii) When the betting target is set moderately or too low, the betting transfer share ratio has an inverse relationship with the optimal valuation level. However, the retailer will increase its effort level at this time. (iv) In addition, the optimal valuation level is affected by the retailer’s firm growth and ordering price.
Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria
Authors: Kodjo Amengor Cedric Dzidzor , Amaning Danquah Cynthia , Adusei Emmanuel Bentil Asare , Kekessie Francis Klenam , Ofosu-Koranteng Francis , Peprah Paul , Harley Benjamin Kingsley , Orman Emmanuel , Adu Joseph , Saaka Yussif
Published: September 2022

A library of six compounds with new hybrids in a single molecule triazole ring attached to the phosphonium salts was synthesized. Click chemistry was, however, used to synthesize the 1-, 2-, and 3-triazole intermediates as a tether for the hybrid phosphonium salts. Their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and Mycobacterium smegmatis mc2155 was determined using the HT-SPOTi assay. Compound 2 showed the most effective antimicrobial activity as it inhibited the growth of Pseudomonas aeruginosa and Staphylococcus aureus at 0.0125 µg/mL and 31.25 µg/mL, respectively. From the FICI data, compounds 2ET-TOL (2) and RABYL-TOL (4) successfully modulated the activities of amoxicillin against Pseudomonas aeruginosa and Staphylococcus aureus. All the test compounds exhibited a concentration-dependent biofilm formation inhibition against S. aureus, except P-Z (compound 6). Compounds P-MEOXY (1) and 2ET-TOL (2) exhibited mild activity against P. aeruginosa with compound 4 showing antimycobacterial activity at 500 µg/mL.
The Effect of Mobile Social Media Sharing Behavior on the Subjective Well-Being and Mental Health Regulation of Internet Users
Authors: Lu Mingqing , Ma Qiangqiang
Published: September 2022

Mobile Healthcare Social Media (MHSM) is an innovative combination of mobile devices and mobile communication technology. How can users shift from spontaneous to conscious cognitive mode, break their usage inertia, and actively adapt to the social structure of mobile health social media to improve information-sharing performance? This study uses adaptive structuring theory as the theoretical foundation to deeply analyze adaptive information-sharing behavior and its specific forms in the mHealth social media environment; it uses cognitive shift theory and social exchange theory as the theoretical framework to comprehensively explore the antecedent motivations of users engaging in adaptive information-sharing behavior and its posterior effects. Theoretically, it promotes the innovation and development of information-sharing behavior research and the further deepening of the application of adaptive structuring theory at the information behavior level. It is also conducive to bridging the digital divide and maximizing the value of health information resources. This paper takes 1000 survey data as the experimental data source for studying the influence of mobile social media sharing behavior on the subjective well-being and mental health regulation of Internet users and concludes that in practice, it is beneficial to optimize the design of information-sharing-related functions in mobile health social media, improve the effect of user information sharing in mobile health social media environment, and enhance the efficiency of information sharing so that mobile social media sharing behavior can better contribute to the subjective well-being and mental health regulation of Internet users. This paper has an obvious psychological adjustment effect on groups who use too much social media and can help them analyze why they are affected by some social media, thereby producing psychological effects.
Effect of Targeted Care plus Exercise Intervention on Blood Glucose Levels and Maternal and Newborn Outcomes in Patients with Gestational Diabetes Mellitus
Authors: He Xiufang , Geng Xiaqing , Sha Manting , Jia Yan , Cui Gaiying
Published: September 2022

Objective. To evaluate the effect of targeted care plus exercise intervention on blood glucose levels and maternal and newborn outcomes in patients with gestational diabetes mellitus (GDM). Methods. A total of 96 patients with GDM admitted to our hospital between March 2018 and January 2020 were recruited and assigned to receive either routine nursing (routine group) or targeted care plus exercise intervention (study group) via random method, with 48 patients in each group. Outcome measures included blood glucose, immune function, maternal and newborn outcome, and nursing satisfaction. Results. The patients in the study group had significantly lower amniotic fluid index (AFI), weight at delivery, body mass index (BMI), and weight gain during pregnancy than patients in the routine group (

P
<
0.05

). There was no statistically significant difference in blood glucose between the two groups of patients before the intervention (

P
>
0.05

). Targeted care plus exercise intervention resulted in significantly lower levels of fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPBG), and blood glucose before bed versus routine care (

P
<
0.05

). The patients with targeted care plus exercise intervention had higher immunoglobulin G (IgG) and IgM levels; higher CD3+, CD4+, and CD8+ levels; and lower lgA levels versus those with routine care (

P
<
0.05

). Targeted care plus exercise intervention was associated with a lower incidence of negative pregnancy outcomes and a higher satisfaction versus routine care (

P
<
0.05

). Conclusion. Targeted treatment plus exercise intervention efficiently controls blood glucose levels in GDM patients, improves immunological function, lowers the risk of pregnancy problems, improves pregnancy outcomes, and promotes patient satisfaction, indicating a high potential for therapeutic development. Targeted treatment combined with exercise intervention is encouraged following effective pharmacological interventions to facilitate recovery.
A Review on the Environment Perception and Control Technologies for the Hyperredundant Manipulators in Limited Space
Authors: Liu Jiaxin , Zhang Aoshun , Li En , Guo Rui , Li Shengchuan , Luo Mingrui
Published: September 2022

As a typical kind of special robot with high flexibility and maneuverability, the hyperredundant manipulators (HRM) which can work in the narrow and complex space arose much related research work. Due to the particularity of the environment and the structural complexity of the manipulators, there are many problems for the HRM in specific applications. This paper summarizes some representative research works for HRM, including the mechanical design, environment perception, robotic navigation, and trajectory control. In order to make the design of the HRM systems more suitable for applications, the technical problems of current research are analyzed to address the key issues for the improvement. Finally, the prospect of spatial reachability, structural compactness, operation accuracy, and interaction friendliness of hyperredundant manipulators are presented.
Small Nucleolar RNA and C/D Box 15B Regulate the TRIM25/P53 Complex to Promote the Development of Endometrial Cancer
Authors: Wen Jing-tao , Chen Xi , Liu Xin , Xie Bu-min , Chen Jing-wen , Qin Hong-lei , Zhao Yang
Published: September 2022

Background. Endometrial cancer is associated with a high mortality rate, which warrants the identification of novel diagnostic markers and therapeutic targets. The aim of this study is to evaluate the role of SNORD15B in the development of endometrial cancer and explore the potential underlying mechanisms. Methods. Bioinformatics was used to analyze the expression level and prognostic relevance of SNORD15B in endometrial cancer. The Ishikawa and HEC-1B cells were respectively transfected with SNORD15B expression plasmid and an antisense oligonucleotide, or the corresponding empty vector and a nonspecific sequence. The malignant phenotype of the suitably transfected cells was assessed by standard in vitro functional assays and the establishment of in vivo xenografts. The expression levels of the specific markers were analyzed with RT-qPCR and western blotting. The subcellular localization of P53 was determined by analyzing the nuclear and cytoplasmic fractions. RIP, Co-IP, and immunohistochemistry were performed as per standard protocols. Results. SNORD15B was overexpressed in the endometrial cancer tissues and correlated to a poor prognosis. Ectopic expression of SNORD15B in Ishikawa cells inhibited apoptosis, increased the proliferation, invasion, and migration in vitro, and enhanced their tumorigenicity in vivo. SNORD15B overexpression also upregulated TRIM25 and accelerated P53 accumulation in the cytoplasm of the endometrial cancer cells. Conclusion. SNORD15B functions as an oncogene in endometrial cancer by targeting the TRIM25/P53 complex and blocking the nuclear translocation of P53.
Effects of Perinatal Cognitive Behavioral Therapy on Delivery Mode, Fetal Outcome, and Postpartum Depression and Anxiety in Women
Authors: Guo Xiuqin , Guo Xiuling , Wang Ruijun , Zhang Yuan
Published: September 2022

Objective. To explore the effects of perinatal cognitive-behavioral therapy on delivery mode, fetal outcome, and postpartum depression and anxiety in women. Methods. The clinical data of 88 perinatal pregnant women who came to our hospital from May 2020 to May 2021 were retrospectively analyzed and grouped into the routine group and the cognitive behavioral intervention group according to different perinatal nursing methods, with 44 cases in the cognitive behavioral intervention group received by cognitive behavioral therapy, and 44 cases in the routine group obtained by routine obstetric care during the perinatal period. The anxiety of pregnant women was evaluated by the Hamilton Anxiety Scale (HAMA). The positive cooperation and negative response of the perinatal pregnant women in two groups were recorded. The trial delivery rate, mode of delivery, amount of intrapartum bleeding, neonatal Apgar score, and visual pain simulation score (VAS) within 48 hours after delivery of the pregnant women in the two groups were also recorded and compared. The incidence of depression of pregnant and lying-in women in the two groups was recorded on the 5th and 42nd day after delivery. Results. After the intervention, the anxiety score of pregnant women in the cognitive behavioral intervention group was significantly lower than that in the routine group (

P
<
0.05

). Following the intervention, the positive cooperation score of pregnant women in the cognitive behavioral intervention group was prominently higher than that in the routine group, and the negative cooperation score was observably lower than that in the routine group (

P
<
0.05

). The rate of spontaneous delivery in the cognitive behavioral intervention group was significantly higher than that in the conventional group (

P
<
0.05

), while the VAS score and blood loss in the cognitive behavioral intervention group were notably lower than those in the routine group (

P
<
0.05

). The proportion of women with EPDS score <9 points, i.e., no postpartum depression both on the 5th and 42nd day after delivery, were significantly higher than those in the routine group (

P
<
0.05

), whereas the proportion of patients with postpartum depression symptoms scored 9–13 points were markedly lower than those of the routine group (

P
<
0.05

). Conclusion. The cognitive behavioral therapy can improve the adverse physiological and psychological reactions of pregnant women with perinatal anxiety disorder, enhance the natural delivery rate and postoperative recovery, reduce the risk of neonatal asphyxia, and ensure the safety of mothers and infants in the perinatal period. Compared with routine nursing, this intervention method is more targeted and scientific, and is worthy of clinical promotion.
Image-Based Precision Measurement Technology for the Quality Inspection of Crane Boom Materials
Authors: Liu Honghua , Tan Wenping , Cao Shen , Li Hongmei
Published: September 2022

With the slow rise of the construction industry, cranes, as indispensable mechanical equipment in construction projects, are widely used in the lifting and handling of specific space ranges of construction projects. The quality of crane booms is particularly important for safety. This paper uses image measurement methods including filter processing, mean filtering, and Gaussian filtering to detect the quality of the crane boom material. The image is processed by the wavelet transform and Fourier transform. The grayscale transformation stretching method is applied to the surface image analysis of the boom material to obtain the final inspection. The research results show that the use of image measurement methods can effectively measure the thickness of the crane boom material, the geometric information of the boom material, and the surface roughness of the material and obtain effective image information. The detection accuracy reaches 98.1%. The error can be controlled better. The inspection and research on the quality of crane jib materials can ensure the quality and performance of crane jib materials, reduce the potential safety hazards of cranes during operation, and improve safety. This article organically combines workpiece surface roughness detection with digital image processing technology to preprocess the surface picture of the arm tube material. On this basis, the texture features in the image are extracted and programmed to calculate, and the final workpiece is obtained by the surface roughness value, which proves the feasibility of this method. The research results have very important practical significance for the detection of the quality of the arm tube material and the improvement of the quality level of the arm tube material.
Enhanced Light Emission from Type-II Red InGaN/GaNSb/GaN Quantum-Well Structures
Authors: Park Seoung-Hwan , Shim Jong-In , Shin Dong-Soo
Published: September 2022

Electronic and optical properties of type-II InGaN/GaNSb/GaN quantum-well (QW) structures are investigated by using the multiband effective mass theory for potential applications in red light-emitting diodes. The heavy-hole effective mass around the topmost valence band is not affected much by the insertion of the GaNSb layer, and the optical matrix elements are greatly increased by the inclusion of the GaNSb layer in the InGaN/GaN QW structure. As a result, the type-II InGaN/GaNSb/GaN QW structure shows a much larger emission peak than the conventional type-I QW structure owing to the decrease in spatial separation between electron and hole wavefunctions, in addition to the reduction of the effective well width. It is also observed that the In content in InGaN well can be significantly reduced for the type-II QW structure with a large Sb content, compared to that for the type-I QW structure.
Harnessing Microbiota to Improve Immunotherapy for Gastrointestinal Cancers
Authors: Goc Jeremy , Sonnenberg Gregory F.
Published: September 2022

Immune checkpoint blockade has revolutionized opportunities for therapeutic intervention in cancer but demonstrates a low frequency of response in most patients and in some common types of tumors. An emerging paradigm supports the notion that trillions of normally beneficial microbes inhabiting the gastrointestinal tract, termed the microbiota, critically impact the success or failure of antitumor immunity induced by immune checkpoint blockade. Here, we briefly summarize the current knowledge on how interactions between the microbiota and immune system are contributing to the outcome of cancer immunotherapy. We propose that this immune–microbiota dialogue is particularly important in gastrointestinal cancers that exhibit striking resistance to immune checkpoint blockade and inherently develop in a unique environment that is rich in both immune-cell networks and direct exposure to the microbiota. Finally, we focus on how future studies should determine whether microbiota can be harnessed as a strategy to boost antitumor immunity in these contexts and beyond.

See related article, p. 1291
Thrombolysis in Myocardial Infarction Risk Index Predicts 1-Year Mortality in Patients with Heart Failure: An Analysis of the SELFIE-TR Study
Authors: Güvenç Rengin Çetin , Güvenç Tolga Sinan , Ural Dilek , Çavuşoğlu Yüksel , Yılmaz Mehmet Birhan
Published: September 2022

Objective: Predicting outcomes is an essential part of evaluation of patients with heart failure (HF). While there are multiple individual laboratory and imaging variables as well as risk scores available for this purpose, they are seldom useful during the initial evaluation. In this analysis, we aimed to elucidate the predictive usefulness of Thrombolysis in Myocardial Infarction Risk Index (TIMI-RI), a simple index calculated at the bedside with three commonly available variables, using data from a multicenter HF registry. Subjects and Methods: A total of 728 patients from 23 centers were included in this analysis. Data on hospitalizations and mortality were collected by direct interviews, phone calls, and electronic databases. TIMI-RI was calculated as heart rate × (age/10)2/systolic pressure. Patients were divided into three equal tertiles to perform analyses. Results: Rehospitalization for HF was significantly higher in patients within the 3rd tertile, and 33.5% of patients within the 3rd tertile had died within 1-year follow-up as compared to 14.5% of patients within the 1st tertile and 15.6% of patients within the 2nd tertile (p < 0.001, log-rank p < 0.001 for pairwise comparisons). The association between TIMI-RI and mortality remained significant (OR: 1.74, 95% CI: 1.05–2.86, p = 0.036) after adjustment for other variables. A TIMI-RI higher than 33 had a negative predictive value of 84.8% and a positive predictive value of 33.8% for prediction of 1-year mortality. Conclusion: TIMI-RI is a simple index that predicts 1-year mortality in patients with HF; it could be useful for rapid evaluation and triage of HF patients at the time of initial contact.
The Huntington Library Hours of Isabella of Portugal, Simon Bening, and the Confection of a Manuscript for an Iberian Empress in the First Half of the Sixteenth Century
Authors: Clark Gregory T.
Published: September 2022

When, where, and by whom was Isabella of Portugal’s Huntington Library Hours (HM.1162) written and decorated? The author proposes here that the body of the manuscript, written in Toledo, and 15 small miniatures painted in the 1510s by Simon Bening of Bruges were sent to the southern Netherlands. There associates of the Morgan 491 Master provided the Bening illuminations with decorative enframements and accompanying devotional texts; two new half-page miniatures were also painted. All of that handiwork was then integrated into the manuscript before its dispatch back to Spain shortly before Isabella’s marriage to the emperor Charles V in 1526.