bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of efficacy of topical alcaftadine (0.25%) versus olopatadine (0.1%) in allergic conjunctivitis
Authors: Kumar L Kiran , Gowda M S  Smitha
Published: January 2022

The most common atopic ocular condition in clinical practice is allergic conjunctivitis. One of the preferred treatment options for allergic Conjunctivitis is anti histamines eye drops. The study purpose is to compare the clinical efficacy between topical alcaftadine 0.25% and olopatadine hydrochloride 0.1% in allergic conjunctivitis patients.

A prospective, randomized, open label, parallel group, comparative study was conducted on 60 Patients with bilateral allergic conjunctivitis (30 in each group) after taking an informed written consentand was evaluated from May 2018 to November 2018. Patients were randomized into 2 groups of 30 each, group A received topical Alcaftadine 0.25% twice daily and patients in Group B received topical olopatadine hydrochloride 0.1% twice daily for 2 weeks. The patients were evaluated on first visit (baseline) followed by 7 and 14 day after starting the treatment. At each visit signs and symptoms were evaluated and rated using a scale from 0-3(0-Absent, 1- mild, 2 moderate and 3- severe). The change from baseline in the mean scores of itching, hyperemia, photophobia and tearing on day 14 is the primary outcome variable.

: The signs and symptoms of allergic conjunctivitis were reduced by 2 weeks from baseline after using both the drugs. Relative significant efficacy was achieved in alcaftadine group for Itching, hyperemia and photophobia, but not for tearing (p=0.3).

When compared to 0.1% olopatadine hydrochloride, 0.25% alcaftadine is more effective in reducing the symptoms of all types of allergic conjunctivitis except those mentioned in exclusion criteria.
Comparison of visual acuity measured by ETDRS based smart phone applications I sight pro and Peek acuity versus traditional Snellen\'s chart visual acuity in children 6-14 years in a tertiary care institute in India
Authors: Abhilash B  , Adyanthaya Sinchana
Published: January 2022

Covid-19 pandemic has led to children missing schools due to which eye care screening activities at schools have taken a backseat. To mitigate this home based visual acuity estimation smartphone applications are increasingly being used for the purpose of tele-ophthalmology purposes, although with no validation of the same. We aim to fulfil this lacunae.

Current study was a cross sectional analysis on 286 eyes of 148 children aged between 6years to 14years attending our OPD from April 2021 to June 2021, with non-acute ocular symptomatology. Snellen’s distant visual acuity was compared against the visual acuity recorded by smart phone based Isight pro app and Peek acuity smart phone app. Statistical analysis was performed by Bland Altmann analysis by using SPSS version 21 and p<0.05 was taken as the level of significance.

The mean differences between the smartphone-based test Isight pro and the Snellen’s chart and the smartphone-based test Peek acuity and Snellen’s acuity data were 0.06 (95%CI, 0.04–0.08) and 0.07 (95%CI,0.05–0.09) logMAR, respectively. Time taken to test visual acuity by Snellen’s chart was approximately 118.2±21.38 seconds, whereas with Isight pro and Peek acuity smart phone apps the time for testing was approximately 92±15.88 seconds and 94.03±19.73 seconds respectively. P<0.05.

The mean visual acuity was comparable with Snellen’s chart and ETDRS based smart phone apps like Isight pro and Peek acuity. The mean time to assess visual acuity was slightly more in Snellen’s acuity than with smart phone based apps. Inability to access eye care services through screening activities in schools has been mitigated effectively by using these smart phone apps. Hence these smart phone apps can be effectively used in tele-ophthalmologic practice and screening activities in these COVID-19 pandemic times.
To determine functional visual improvement after cataract surgery in eyes with age related macular degeneration
Authors: Joshi Deepika , Shristi Sourav
Published: January 2022

To determine whether patients with Age related macular degeneration (ARMD) benefit from cataract surgery in terms of best corrected visual acuity (BCVA) and to assess impact of surgery on progression of ARMD.

: A prospective study was carried out of patients with and without ARMD undergoing cataract surgery at our department. Patients were divided into two groups- Group A (cases) with ARMD and Group B (controls) without ARMD and other retinal pathology. BCVA of cases was recorded on day 1, day 14, 1 month and 1/month and compared to that of controls.

: BCVA significantly improved but markedly less than that experienced by control eyes. No increased incidence in progression to wet form of ARMD.

Cataract surgery is safe in ARMD patients with no evidence of increased complications or rates of disease advancement.
Changes in symptoms of dry eyes in health professionals with increased duration of wearing the mask
Authors: Gupta Akansha , Chaurasiya Ritesh Kumar
Published: January 2022

: In normal population and patient, the significant increase in dry eyes manifestations have been observed. Similarly, aggravated symptoms and complaints of dryness have also been observed in clinical and hospital staff by using a face mask for an extended time period. The purpose of the study was to observe the association between symptoms of dry eyes and the duration of using masks in health professionals.

: An unspecified questionnaire was distributed using Google Forms through different social media platforms, asking each respondent to contribute to the survey. Data were collected from December 2021 to January 2021. Statistical analysis was performed using SPSS software. Statistical significance was considered if p-value was less than 0.05.

A total of 39 responses was included for analysis in the study. There was a positive correlation between the frequency of the symptoms of dryness and the duration of using the mask. Similarly, the severity of the symptoms for dry eyes was strongly correlated with an increase in the frequency of symptoms for dry eyes.

The finding reflects that the frequency of the dryness along with the severity will increase with the increase in the duration of wearing a mask. Moreover, it also suggests that cloth mask is the probable predisposing factor for the increase in the dry eye symptoms in this study.
A study to assess the efficacy of topical cyclosporine A 0.05% in the management of dry eye with meibomiam gland dysfunction
Authors: Reddy Prajwalli , Umam Wajeeha
Published: January 2022

: Dry eye is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface. Meibomian Gland Dysfunction (MGD) is an abnormality of the meibomian gland that blocks the secretion of lipids. Without sufficient lipid production, tears evaporate quickly causing Dry Eye.

MGD is associated with multiple pathological mechanisms including inflammation, microbial factors and lipid deficiencies. Topical Cyclosporine A (CsA) 0.05% is a calcineurin inhibitor that reduces inflammation by specifically inhibiting T‑cell activity, which reduces ocular surface inflammation and improves tear film dynamics.

This was a prospective observational study done on 100 patients at the Department of Ophthalmology Basaveshwar teaching and general hospital, on patients of dry eyes due to meibomian gland dysfunction. Patients who were diagnosed with dry eyes due to meibomian gland dysfunction were invited to take part in the study. Patients were divided randomly into two groups of 50 patients each. This study, was explained in detail to them. An informed consent was obtained. Patients fulfilling the inclusion criteria were listed.

All OSDI scores (symptom intensity, frequency and aggravation) revealed decreasing patterns throughout the observation period in both the groups. In single analysis, the cyclosporine A 0.05% group showed a significant improvement for each score at 3 months (p < 0.01, p = 0.01, p = 0.02, respectively). The mean TBUT after treatment in the group A (cyclosporine A group) increased to 12.36± 3.58(p<0.001) seconds, and in the group B (Control group) the TBUT score increased to 11.01±3.06 seconds. After 3 Months, there was statistically significant improvement in the mean Schirmer’s scores in both the treatment groups, however improvement was significantly greater in Cyclosporine A group.

Prior to the treatment in group A (Cyclosporine A) mean Lissamine staining score was 2.73±0.15 and post treatment it reduced to 1.32±0.15 which was statistically significant (P<0.001). In group B (Control group) score before treatment was 2.46±0.15 and after treatment it reduced to 2.39±0.27 (p=0.11), not much difference was seen.

: Findings from our study showed that there were significant improvements in the dry eye conditions due to defect in meibomian gland by treatment of topical Cyclosporine A 0.05% and sodium hyaluronate 0.1%.
Role of B-scan in management of ocular trauma
Authors: Shrivastava Poorva , Shrivastava Lalit
Published: January 2022

The present study aimed to study the effectiveness of B scan in assessing the posterior segment in patients with ocular trauma, so that further treatment plan can be decided and prognosis can be improved.

The study was conducted as a cross-sectional study at tertiary care centre during the study period of 1 year on 42 patients presenting with history of ocular trauma. Patients were subjected to detailed history and ocular examination followed by B scan ultrasonography for ruling out posterior segment pathology.

Mean age of 42.7±20.2 years and 45.2% patients belonged to 41 to 60 years of age. About 54.8% cases were females. About 50% cases had one or the other posterior segment finding. Retinal detachment followed by vitreous hemorrhage were the most common findings, observed in 19% and 11.9% cases respectively. Avulsion of optic nerve was the least common finding (2.4%).

B scan ultrasonography plays an important role in management of patients with ocular trauma for the detection of hidden posterior segment lesions. B scan must be performed routinely in all the cases of ocular trauma for early diagnosis and appropriate management of each case and to reduce the ocular morbidities.
Assessment of knowledge, attitude and practice of diabetic eye care among non-ophthalmic speciality doctors at a tertiary institute in India
Authors: Adyanthaya Sinchana , Babu Mahesh
Published: January 2022

Aim of this study was to assess the knowledge, attitude and practices (KAP) in eye care of diabetics by non-ophthalmic doctors of different specialization.

The was a cross-sectional questionnaire based KAP survey among 108 non-ophthalmic diabetes mellitus treating faculties of various departments at our institute. The level of Knowledge was considered excellent if the overall average score was > 75%, similarly questionnaire focusing on attitude was considered positive if the average score was > 50% and excellent practice constituted an average score > 75%. The findings will be noted in percentages with 95% confidence interval limit.

Out of the 108 subjects, 75.57% {95%CI(61%-78%)} of participants had excellent knowledge, while >87.6% {95%CI(73%-88%)} of participants had a positive attitude towards diabetic eye care, whereas there were glaring deficits in diabetic eye care practices accounting to only 45.5%{95%CI(32.8%-51.4%)} which was considered poor.

Knowledge and attitude regarding diabetic eye care was excellent, there was glaring deficits in the practice of diabetic eye care by non-ophthalmic treating doctors. The deficit was probably due to busy schedule of some doctors, due to lack of uniform eye care protocols of diabetic patients, and lack of updated timely education of eye care practices among non-ophthalmic medical professionals. Hence based on the findings of our study we aim to train and educate our non-ophthalmic medical faculty regularly for adequate and better management of spectrum of diabetic eye disease.
Visual outcomes in pediatric traumatic cataract
Authors: Hasan Sumaiya , Singh Dheerendra , Jat Neha Singh , Buddhe Vivek Paul
Published: January 2022

To study epidemiology, biometry and visual outcomes (with or without posterior capsulorhexis) in cases of pediatric traumatic cataract.

This was a prospective observational study conducted on 30 children of traumatic cataract belonging to an age group of less than 16 years. All patients were subjected to detailed history and ocular examination. Patients underwent cataract surgery with or without intraocular lens (IOL) implantation. Posterior capsulorhexis with posterior optic capture was done in all patients presenting with primary posterior capsular opacity. All patients were followed up till 6 months and surgical outcomes in terms of Best Corrected Visual Acuity (BCVA), and visual axis opacification (VAO) were observed.

Firecracker injury was found to be the most common causal agent, followed by arrow and ball injuries. Males were more commonly injured than females (70%:30%). Open-globe injury was more frequent than closed globe injury (CGI) (53.3%:46.7%). Anterior capsular rupture was the most frequent preoperative complication. Mean axial length was 22.53 which was not significantly different from the fellow eye. 3 patients were left aphakic, 10 patients underwent single piece IOL implantation and 16 patients underwent multipiece IOL implantation. Anterior chamber IOL (ACIOL) was implanted in one case. Intraoperatively 6 patients were found to have posterior capsular plaque and were implanted with multipiece IOL with posterior optic capture. Visual acuity significantly improved in 21 out of 30 eyes from baseline after cataract surgery (p<0.001). 9 patients (30%) had posterior capsular opacification (PCO) on follow up.

Posterior capsular opacity in pediatric traumatic cataracts can be effectively managed with posterior capsulorhexis and posterior optic capture.
Accuracy and predictability of novel MS Excel-based surgically induced astigmatism calculator
Authors: Prabhakar S K , Middha Oshin , George Feba Mary , Kothak Uditi Pankaj , Yadav Prashansa
Published: January 2022

Study of steepening, flattening, clockwise, and counter-clockwise torque effect is indispensable to understand and design surgical induced astigmatism calculator. Hence, in this study by constructing a novel Microsoft Office Excel 2007 based astigmatic calculator following cataract surgery, analysis on the accuracy and predictability evaluated for the performance.

Post-cataract surgery patients from May 2019 to January 2020 at a tertiary medical institution recruited for this present study. Based on Pythagoras principle, MS Excel calculator designed and the law of cousins for calculating the vector magnitude and axis respectively. Manual keratometry measurements for pre and postoperative horizontal (Kh) and vertical (Kv) curvatures established, and statistical analysis for the resultant SIA magnitude and axis deduced with Medcalc software comparing with the existing SIA 2.1 version calculator.

A total of 29 eyes of 25 patients studied with a mean age of 62.55 (±8.08) years, males contributing to 14 (56%), and right laterally in 17 (58%) eyes. MS Excel and SIA 2.1 versions calculated a mean SIA magnitude of 0.66 (±0.47) D and 0.64 (±0.55) D respectively. Pearson coefficient correlation (r=-0.16, p=0.40), paired-two sample test (t value= 0.11, p= 0.91) and ROC curve analysis (AUC = 0.75, p= 0.34, 95% CI= 0.25 to 0.99) calculated. Regression equation (y = 0.75 + -0.14 x) and limits of agreements (95% CI -0.29 to 0.31) analyzed, and, 95% of data points distributed within ±1.96 SD of the line of equality on Bland-Altman difference plots.

The present calculator proclaimed an acceptable accuracy and agreement with a prediction of 0.61 Diopter for every unit change in the magnitude of SIA 2.1 software in addition to consideration of interchangeability.
To study visual and neurological outcome after treatment according to ONTT protocol
Authors: Chaurasia I D , Chaurasia Yogita
Published: January 2022

To evaluate the visual and neurological outcomes of Optic Neuritis Treatment Trial (ONTT).

40 Patients presenting with optic neuritis were enrolled in this study to analyze the Visual and Neurological outcomes after treatment according to ONTT Protocol, with emphasis on signs of anaemia, protein calorie malnutrition, vitamin deficiency, generalized lymphadenopathy, sinusitis, septic foci. Patients were followed up for three subsequent visits to assess the rate of visual recovery.

Maximum patient 35(87.5) treated according to ONTT protocol while 5 (12.5%) treated with oral steroids alone. Maximum 33 eyes (70.2%) attain BCVA > 6/36 after 1st follow-up (with in 1 month) while 10(21.3%) eyes attain BCVA of 6/6 after 1st follow-up. 11 eyes (25.6%) attain BCVA 6/6 after II follow-up.

General prognosis for recovery of vision was good and was slightly worse in more severely affected cases in the present series. Pallor of the optic disc and defect of vision did not always correspond–3 eyes which showed temporal of the disc at the end of follow up had a final vision of 6/9 or better in each eye.
Independent Country Program Review Suriname 2016-2020
Authors: Riveros Luisa , Maciel Odette , Peña-Habib Oliver , Barcellos Andreia
Published: January 2022

This Independent Country Program Review (ICPR) analyzes the IDB Group's country strategy (CS) and country program with Suriname during the 2016-2020 period. ICPRs assess the relevance of the Bank's CS and provide aggregate information on the program alignment and execution. If the available information allows it, ICPRs also report on progress toward achieving the objectives that the IDB Group established by the CS. This review by the Office of Evaluation and Oversight (OVE) is intended to provide the Boards of Executive Directors of the IDB and IDB Invest with useful information to analyze the country strategies submitted for their consideration.
Noticias del BID: Vol. 6, no. 11, enero 1980
Authors:   Banco Interamericano de Desarrollo
Published: January 2022

Noticias del BID, publicación mensual que tiene por objetivo informar acerca de las actividades del Banco Interamericano de Desarrollo.
Noticias del BID: Vol. 8, no. 10, diciembre 1981
Authors:   Banco Interamericano de Desarrollo
Published: January 2022

Noticias del BID, publicación mensual que tiene por objetivo informar acerca de las actividades del Banco Interamericano de Desarrollo.
Assessing Sustainability of Paddy Farmers in Peri-Urban Khulna: An Application of Farmer Sustainability Index
Authors: Sultana Rashmia , Kabir Kazi Humayun , Hasan Kamrul , Imran Sardar Al , Khan Md. Ayatullah
Published: January 2022

Association of sustainability agriculture and farming practices is somehow closely connected. There are necessary different farming practices for both adjusted and unadjusted PFSI measurement. The study observes practices of paddy farming and if farmers are practicing agriculture sustainably by estimating PFSI in three villages of Gutudia union. The objective is to spot the present agricultural practices and accessible sustainable practices, to examine the sustainability degree at field beneath the present paddy farming systems using PFSI and additionally to identify recommendations. The unit of analysis is 50 farmers and measured on a scale of 0 to 100 and also through Saltiel, Bauder, and Palakovich (1994) index. The results discovers that the average sustainability level which is presumably quite unsustainable this shows the necessity for more extension of correct practices. Chi-square analysis shows that the level of farmers’ awareness toward sustainable agriculture and positive attitude are considerably different with the level of PFSI.
Changes of Strategic Pricing Policy of Logistics Service Providers in Financial Macroeconomic Instability
Authors: Simek Libor , Cempirek Vaclav , David Andrej , Galierikova Andrea
Published: January 2022

This paper aims to examine the influence of macroeconomic instability on the microeconomic environment, especially on financial strategy after the application of strategic pricing policy by providers of logistics services and make recommendations for providers who use pricing as a marketing tool. Special attention is paid to enhancing their competitive position in times of economic crisis. The research is based on an analysis of the situation during the 2008–2009 economic crisis. It is hypothesized that the number of providers who applied a strategic pricing policy after its culmination in 2010 was higher than in 2008 (shortly before the onset of the crisis). The conclusions derived are then transferred to the period of the 2020 coronavirus economic recession under the assumption of the same analogical characteristics of both periods. The paper does not speculate – its purpose is to present a thorough and complex analysis of the situation by employing a wide range of statistical instruments, thereby attaining results of a very high level of statistical reliability. The study has the potential to be a valuable contribution to the literature in its respective field, especially during global anti-Covid measures, which makes the theme of strengthening competitive positions of logistics service providers very topical.
A Pilot Study on Immunohistochemical Expressions of NF-ĸB, Cyclin-D1, VEGF, and Cox-2 in Advanced Stage Laryngeal Carcinoma
Authors: Rahaju Pudji , Wirattami Ayunita Tri , Sandra Ferry , Kurniawan Steffi , Nisa Khairun , Soehartono Soehartono , Handoko Edi , Wahyudiono Ahmad Dian , Surjotomo Hendradi , Yudhanto Hendy Setyo , Setjowati Nanik
Published: January 2022

BACKGROUND: Progression of laryngeal carcinoma can be classified with the clinical staging, however there are different patterns of progressions observed in the patient with the same clinical stage which also affects their prognoses. Therefore biomarkers should be used. Nuclear factor (NF)-ĸB, Cyclin-D1, vascular endothelial growth factor (VEGF), cyclooxygenase (Cox)-2 have been reported for laryngeal carcinoma. However, it is still unclear how these markers are expressed and correlated in advanced stage laryngeal carcinoma. Therefore current study was conducted to investigate the expressions of NF-ĸB, Cyclin-D1, VEGF and Cox-2 and their correlations in advanced stage laryngeal carcinoma.METHODS: Subjects were recruited and laryngeal biopsies were collected, fixed in formalin and prepared for immunohistochemistry. The immunohistochemistry was performed using mouse monoclonal anti-NF-kB p65, anti-Cyclin-D12 anti-VEGF, and anti-Cox-2 antibodies. The immunohistochemistry results were documented and measured using ImmunoRatio. Pearson or Spearman correlation test was used based on the results of Shapiro-Wilk test of normality. A p-value of less than 0.05 is considered statistically significant.RESULTS: Twelve male subjects were included in this study. Expressions of NF-ĸB, Cyclin-D1, VEGF dan Cox-2 were clearly observed. Mean of NF-ĸB, Cyclin-D1, VEGF dan Cox-2 IHC expression levels measured with ImmunoRatio were 57.50±20.06%, 45.00±24.31%, 43.33±17.23% and 40.42±16.98%, respectively. There was significant correlation between the expressions of VEGF dan Cox-2 (p=0.031, r=0.622).CONCLUSION: Since correlation between the VEGF and Cox-2 expressions was statistically significant, VEGF and Cox-2 might have important roles in the growth, invasion and metastasis of laryngeal carcinoma.KEYWORDS: advanced stage laryngeal carcinoma, immunohistochemistry, NF-ĸB, Cyclin-D1, VEGF, Cox-2
Caffeic Acid Inhibits RANKL and TNFa-induced Osteoclastogenesis by Targeting TAK1-p44/42 MAPK
Authors: Sandra Ferry , Putri Jennifer , Limen Hilary , Sarizta Blanca
Published: January 2022

BACKGROUND: The potential of the caffeic acid in other important Receptor Activator Nuclear Factor kB Ligand (RANKL)-Tumor Necrosis Factor (TNF)a-induced osteoclastogenic signaling pathways has not been known. Therefore, the current study was conducted to explore as well as to understand the inhibition potential of caffeic acid.METHODS: RAW264.7 cells were cultured, treated with caffeic acid, RANKL and TNFa. Tartrate Resistant Acid Phosphatase (TRAP) staining was performed to detect TRAP+ osteoclast-like polynuclear cells. To detect the activity of p44/42 Mitogen Activated Protein Kinase (MAPK), Akt, and Transforming Growth Factor-β-activated Kinase (TAK)1, the phosphorylated forms of the proteins were investigated with the immunoblotting assay.RESULTS: Pre-treatment of caffeic acid inhibited the RANKL and TNFa-induced differentiation of RAW264.7 cells into TRAP+ osteoclast-like polynuclear cells. RANKL and TNFa induced phosphorylation of p44/42 MAPK at Thr202/Tyr204, phosphorylation of Akt at both Ser473 and Thr308 and phosphorylation of TAK1 at Ser412. Pre-treatment with caffeic acid prior to the RANKL and TNFa induction, inhibited the phosphorylation of MAPK, and TAK1, but not Akt.CONCLUSION: Caffeic acid might regulate the RANKL-TNFa-induced osteoclastogenic pathway in RAW264.7 by targeting TAK1, which later activation of p44/42 MAPK was abolished.KEYWORDS: caffeic acid, osteoclastogenesis, p44/42, Erk1/2, Akt, TAK1, RAW264.7
Higher Neutrophil-lymphocyte Ratio in TB/HIV Co-infection Compared to Pulmonary Tuberculosis
Authors: Sulastri Nuni , Alisjahbana Bachti , Livia Resvi , Sahiratmadja Edhyana
Published: January 2022

BACKGROUND: Neutrophils and lymphocytes play a significant role in inflammation and a high ratio of neutrophils over lymphocytes (NLR) has been used as an inflammatory marker to predict the severity of various diseases. Here we compared the NLR among pulmonary tuberculosis and TB/HIV co-infection.METHODS: A retrospective cross-sectional study was conducted, included patients with pulmonary TB without cavitation TB (n=50), with cavitation TB (n=50) and HIV co-infection (n=27). Complete blood count was examined, including neutrophils and lymphocyte. NLR was calculated and compared between groups. RESULTS: Neutrophils were significantly higher (p=0.004) in TB with cavitation compared to those with no cavitation (8.27±1.45 x103/μL vs. 6.61±1.4 x103/μL, respectively); whereas the lymphocytes were similar in both groups, resulting in a significantly higher NLR (p=0.009) in pulmonary TB with cavitation compared to pulmonary TB with no cavitation (5.98±1.85 vs. 4.42±1.86, respectively). On the contrary, both neutrophils as well as lymphocyte were significantly lower in TB/HIV compared to pulmonary TB, which for neutrophil were 5.14±2.19 x103/μL vs. 7.4±1.45 x103/μL, respectively (p=0.003) and for lymphocyte (1.02 ±0.57 x103/μL vs. 1.57±0.64 x103/μL, respectively (p=0.001), resulting in a significantly higher (p=0.041) NLR value in TB/HIV (6.05±2.67) compared to pulmonary TB (5.16±1.88).CONCLUSION: High NLR in pulmonary TB with cavitation as well as in TB with HIV co-infection may be of great interest for biomarker in TB severity. Further study confirming NLR as potential marker is imperative.KEYWORDS: lymphocyte, neutrophil, NLR, tuberculosis, TB/HIV
Lower GCS is Related to Poor Outcome among Acute Stroke Patients with COVID-19 in A Tertiary Referral Hospital in Indonesia
Authors: Kembuan Mieke Actress Hanna Nelly , Mawuntu Arthur Hendrik Philips , Yohanna Yohanna , Feliana Feliana , Tumboimbela Melke Joanne
Published: January 2022

BACKGROUND: The Coronavirus disease 2019 (COVID-19) pandemic has forced the health workforce to take mitigative measures such as physical distancing, screening, personal protective equipment donning, and confinement on patient care. We aimed to study the outcome of acute stroke patients with suspected, probable, or confirmed COVID-19 in a tertiary referral hospital in Indonesia during the first year of COVID-19 pandemic.METHODS: This was a retrospective study examining all medical records of adult patients suffering from acute stroke with suspected or confirmed COVID-19 who were admitted to R.D. Kandou Hospital, Manado, Indonesia, between March 2020 to March 2021. Clinical and laboratory parameters were compared between subjects with poor and good outcomes based on Glasgow Outcome Scale (GOS), divided into poor outcome (GOS 1-3) and good outcome (GOS 4-5).RESULTS: Fourty-six eligible subjects were enrolled in the study. Based on the GOS, 36 subjects (78.3%) were admitted to the hospital with poor prognosis. On admission, the median Glasgow Coma Scale (GCS) was 11, breathlessness was found in 54.3% of subjects, fever was found in only 15 subjects (32.6%), and the lowest oxygen saturation on admission 95%. We found that GCS significantly related to outcome after controlled for other factors using the logistic regression method (p=0.03; 95% CI=1.08-4.78).CONCLUSION: Lower GCS can be used to predict poor outcome in acute stroke patients with COVID-19.KEYWORDS: COVID-19, acute stroke, Glasgow Coma Scale, outcome, Indonesia
NPC-Exosome Carry Wild and Mutant-type p53 among Nasopharyngeal Cancer Patients
Authors: Kadriyan Hamsu , Prasedya Eka Sunarwidhi , Pieter Nova Audrey Luetta , Gaffar Masyita , Akil Amsyar , Bukhari Agusalim , Budu Budu , Zainuddin Andi Alfian , Masadah Rina , Romdhoni Achmad Chusnu , Punagi Abdul Qadar
Published: January 2022

BACKGROUND: Nasopharyngeal cancer (NPC) is known to release a specific exosome. NPC-derived exosome (NPC-Exo) could carry p53. However, information regarding the type of p53 carrier on NPC-Exo remains limited. This study aims to introduce our important findings regarding the type of p53 NPC-Exo cargo.METHODS: Serum from patients with NPC were prepared for exosome isolation with Seramir Exoquick by following the manual instructions. RT-PCR was conducted to determine the expression levels of latent membrane protein 1 (LMP-1) and p53 in the exosome isolate. Partial sequencing of p53 amplicon was conducted to determine mutation type of p53.RESULTS: There were 8 patients enrolled in this study. According to RT-PCR results, the expression levels of LMP-1 and p53 varied in the NPC-Exo isolate. Based on sequencing analysis, 1 case of p53 mutation was noticeable.CONCLUSION: According to current results, the NPC-derived exosome potentially carries not only wild type but also mutant type p53. Further research is needed to explore deeper the effect of the mutant type p53 as an exosome carrier in the clinical application.KEYWORDS: Nasopharyngeal cancer, exosome, p53, mutation
CMMC v1.02 ile ISO IEC 27001 Standardının Karşılaştırılması ve CMMC’ye Geçiş İçin Yapılması Gerekli Temel Faaliyetler
Authors: COŞAR İsmail Yiğit , TÜFEKCİ Aslıhan
Published: January 2022

Gelişen teknoloji ile birlikte bilgi güvenliğinin önemi hem bireysel hem de kurumsal ölçekte her geçen gün artmaktadır. Özellikle bilgi güvenliği yönetimine sistemsel bakış açısının kazandırılması açısından ISO/IEC 27001 standardının önemi oldukça fazladır. Ancak zamanla gelişen teknoloji artan veri miktarını ve çeşitliliğini de beraberinde getirmiş, bilgi güvenliğine yönelik tehditler çoğalmış ve bunlara bağlı olarak bazı sektörler için sektöre özel farklı bilgi güvenliği yönetimi modelleri ortaya çıkmıştır. Bunlardan biri de ABD Savunma Bakanlığı tarafından savunma sanayi sektörüne özel olarak geliştirilen ve İngilizce adıyla “Cybersecurity Maturity Model Certification-CMMC” olarak belirtilen süreçte yer alan siber güvenlik olgunluk modelidir. Bu çalışmada ülkemiz savunma sanayinde bilgi güvenliği farkındalığının arttırılması amacıyla söz konusu uygulamalar hakkında temel bilgiler verilmiş, bakış açısının geliştirilmesine katkı sağlayan CMMC v1.02 ile ISO/IEC 27001’e kapsam, gereksinim ve sertifikasyon süreçleri bakımından karşılaştırılmış, yeni bakış açısının dikkate alınması için önerilerde bulunulmuş ve gerçekleştirilmesi gerekli temel faaliyetler açıklanmıştır. Sonuç olarak, elde edilen bilgiler ve bulgular çerçevesinde bilgi güvenliği uygulamalarının gelecekte ne yönde ilerleyeceği ve yapılması gerekenler konusunda değerlendirmeler sunulmuştur.
Challenges facing students in writing theses at the Jordanian universities
Authors: Mohammad El-Freihat Sara
Published: January 2022

The study examined the challenges facing students in the process of writing theses and identify differences in these challenges in light of gender, qualifications, mental status, career status, type of university. A survey descriptive design was employed as a questionnaire was a administrated to a random sample consisting of (438) master degree students. To achieve the study objectives, a questionnaire was used. The study showed that the level of challenges students face when writing thesis was moderate, and statistically significant differences in the level of challenges students face when writing thesis in light of gender, in favor of females; specialization, in favor of science; marital status, in favor of married; career status; in favor of employed, while there were no statistically significant differences in light of type of university. The main conclusions of the study is that material challenges were the most prevalent in the Jordanian universities.  In light of the results, some recommendations were suggested
Keywords: Challenges, Writing Thesis, Jordanian Universities, University Students, Jordan.
The effectiveness of mDPBL as a multimedia-based learning approach.
Authors: Winarno Sri , Andono Pulung Nurtantio , Muthu Kalaiarasi Sonai , Ling Lew Sook
Published: January 2022

This study is aimed to investigate students’ perceptions towards the mDPBL approach as a multimedia-based learning approach. mDPBL approach is a combination of two different teaching approaches (i.e. DIA and PBL) with multimedia. Two departments were selected in this study (i.e. Informatics Engineering and Information System). The survey was divided into two phases, pre-survey and post-survey. 276 students participated in this study. The quasi-experiment method was used with two different ways teaching strategies (i.e. traditional and mDPBL approach). The study revealed that the majority of students have a positive impact on positive learning outcomes in the mDPBL approach. A significant increase in students' perceptions of the effectiveness of the mDPBL approach is proven by an increase in the average score of students' perceptions and perceived effectiveness of 2.67 points or 8.71%, respectively.

Keyword- Multimedia, Traditional approach, mDPBL approach
Virtual teaching: Teachers' perspectives on online virtual classroom effectiveness during and beyond Covid-19
Authors: Al-Subaie Abdullah bin Mohammed
Published: January 2022

The purpose was to investigate the Arabic language teachers' perspectives on online VC effectiveness during and beyond COVID-19.  Participants were 340 teachers. This study employed cross-sectional descriptive method, with the main focus on Arabic Language teachers' perspectives on online VC effectiveness during and beyond COVID-19. Findings from descriptive analysis of the teachers’ responses on the importance of using virtual classrooms in distance education program shoed that the rank agree comes first, where teachers responded with agree in 17 items, 2 with strongly agree and only one item for disagree.  Using one-way analysis of variance (ANOVA), findings showed that there were no statistically significant differences between the responses of the study sample towards the use of virtual classrooms by gender, while academic qualification and years of experience contributed significantly, where those with higher qualification, and who are experts had positive perspectives   on online VCs effectiveness during and beyond COVID-19.

KEYWORDS. Virtual Teaching, Online Virtual Classroom, Covid-19
The effect of cross-curricular integration on pupils’ knowledge gained through experiential learning
Authors: Cotič Nastja , Cotič Mara , Felda Darjo , Krmac Nina
Published: January 2022

This study examined the effects of the cross-curricular model of integrating mathematics and science with experiential learning on the knowledge of 3rd grade primary school pupils in Slovenia. The purpose of this research was to design and implement school lessons rooted in integrating maths with science and concrete experience, and handling real objects. In the experimental group (N=149), maths and science lessons implemented a cross-curricular model which integrated experiential learning. In the control group (N=155), maths and science were taught as separate subjects without experiential learning. The data was collected with pre- and post-tests to establish pupils’ knowledge. Differences between groups were analysed through Mann-Whitney U test and Wilcoxon signed-rank test and showed that pupils from the experimental group performed better at the 2nd and 3rd TIMSS cognitive domain. Findings indicate that the cross-curricular learning model has a positive effect on pupil’s achievement in science and mathematics.

 

Keywords: Cross-curricular integration, mathematics, science, experiential learning, TIMSS, cognitive domains
The influence of Qazaq Kuresi classes on the management of the level of reserves of the athletes' body
Authors: Zhanibek Kuderiev , Zh Beknazarov , Kasymbayeva J. , Sh Shonov E , Minarbekov D. I. , Sydykov N. T.
Published: January 2022

In the Republic of Kazakhstan, specialists in the field of Physical culture and Sports are faced with the problem of increasing interest in practicing folk national sports, based on the creation of both theoretical paradigms and a more evidence-based comprehensive practical database of research in scientific and methodological orientation. The research is aimed at creating a bank of models of bio pedagogical data for coaches and young people engaged in national wrestling, on the influence of Kazakh wrestling classes on the physical fitness of the muscles of the musculoskeletal system of its quality and the cardiac activity of highly qualified wrestlers in the preparatory period of the training process. The research was experimental, and data was analyzed using spss’ correlation coefficient. The results revealed the positive effects of the quality of development management on the level of general and special physical fitness of highly qualified athletes of the national team who constantly train in different teams of the republic.

 

Key words: bio pedagogical data; health orientation; motor and functional capabilities; qazaq kuresi; wrestlers.
The role of discipline "Olympic Education" in training specialists of "Physical Culture and Sport" in Kazakhstan
Authors: Bakhtiyarova Sayagul , Ali Zhalel , Nurbagi Sagidolla , Baitlessova Nursulu , Yergaliyev Askarbek
Published: January 2022

Kazakhstan makes a significant contribution to the development of physical culture and sports in the Olympic games and as such, there is an urgent direction to study the prospects for the development of the educational services market and conduct research on consumers of educational services. The purpose of our study was to study and analyze the activities for the organization and implementation of work, related to the massive introduction of the ideas of Olympism and Olympic education in the daily life of both Kazakhstani specialists in the field of physical culture and sports, and the entire sports community. The study collected data through a survey involving 347 respondents working in the field of physical culture and sports in the Republic of Kazakhstan. Data was analyzed using percentages and content analysis. From the study, it was concluded that Olympic movement and Olympic education make the younger generation much smarter, more humane, more aesthetic and more tolerant.

 

Keywords: Education; Olympic; physical culture ; sports; Olympic movement.
Language teacher practices predicting students’ reading self-efficacy: Jordanian students’ participation in PISA 2018
Authors: Alzubi Emad Mohamad , Attiat Madher Mohammad
Published: January 2022

This study investigated the ability of language teachers’ practices to predict self-efficacy in reading among Jordanian students participating in PISA 2018. The study adopted the secondary analysis method by analyzing the responses of 8,963 15-year-old males and females in 313 schools who participated in PISA 2018. Statistically significant differences in students’ perceptions were found in teacher-directed instruction, teacher support for students, teacher motivating students to engage in reading, and enjoyable reading. Additionally, female students exhibited more reading self-efficacy than male students. There were statistically significant differences in students’ perceptions of controlling the classroom environment, and feedback in favor of males. The multiple linear regression analysis indicated that five factors explained a statistically significant proportion of the variance in self-efficacy in reading (14.7%). Enjoyment of reading was the factor that contributed the most with a percentage of 10.2%, followed by teacher enthusiasm with 3.6%.
 
Keywords: reading self-efficacy; Jordanian students; PISA 2018
Importance of soil science in the European Green Deal : Congress inauguration statement
Authors: Dazzi Carmelo
Published: January 2022

This is the Congress inauguration statement of Professor Carmelo Dazzi (President of the European Society for Soil Conservation) to the international conference “Sustainable Management of Cultural Landscapes in the context of the European Green Deal”, held in Santo Stefano di Camastra (Sicily, Italy) jointly organized by the European Society for Soil Conservation and the European Ecocycles Society on November 9-14, 2021.
New, regenerative approaches to sustainability : Redefining ecosystem functions, environmental management, and heritage conservation
Authors: Nemethy Sandor
Published: January 2022

The international conference “Sustainable Management of Cultural Landscapes in the context of the European Green Deal”, held in Santo Stefano di Camastra (Sicily, Italy) on November 9-14, 2021. aimed to shed light on those environmental, social, economic, and cultural problems of interactions between humankind and its natural environment, which cannot be answered through one single discipline but only by applying a multidisciplinary system approach, built on applied Earth System Science intimately interwoven with social sciences, economics and heritage science. The structure of the Congress mirrored this concept since the overlapping areas of sessions encouraged interdisciplinary thinking and practical approach to the key issues of regional development such as ecosystem protection, green infrastructures, sustainable and multifunctional agriculture, circular economy, renewable energy, regeneration, and conservation of natural environments and conservation of cultural heritage.
Assessment of Flood Hazard Mapping Based on Analytical Hierarchy Process (AHP) and GIS: Application in Kencong District, Jember Regency, Indonesia
Authors: Mujib Muhammad Asyroful , Apriyanto Bejo , Kurnianto Fahmi Arif , Ikhsan Fahrudi Ahwan , Nurdin Elan Artono , Pangastuti Era Iswara , Astutik Sri
Published: January 2022

Flood is one of the most frequent hydrometeorological disasters which leads in economic losses. The first step in flood disaster mitigation efforts is mapping vulnerable areas. Kencong District frequently affected by the annual flooding event. This study aims to assess flood hazard mapping by integrating the AHP method and Geographic Information System. This study used a descriptive quantitative approach through the correlation matrix of the AHP model for each physical environmental factor. These factors include slope, altitude, distance from the river, soil type, Topographic Wetness Index (TWI), and Curvature. Furthermore, with the Geographic Information System (GIS), the weighted overlay stage was carried out to obtain the results of flood-prone areas. Based on the AHP analysis, the most significant factors in determining flood-prone areas were the distance from rivers, slopes, and TWI. The results of flood-prone areas mapping were divided into five classes: from deficient 0.02%, low 4.26%, medium 37.11%, high 51.89%, and very high 6.72%. Validation of GIS mapping results with data in the field has an AUC value of 84%, which indicates that the prediction of the AHP-GIS model is perfect in flood-prone areas mapping in the Kencong District. The integration of AHP method and Geographic Information System in flood hazard assessment were able to produce a model to evaluate the spatial distribution of flood-prone areas.
Keywords : Flood Hazard Mapping; Multi-criteria decision analysis; AHP Model; GIS; Jember
 
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Assessing the Effectiveness of Geography-based Online Learning During the Covid-19 Pandemic in Higher Education
Authors: Abdi Abdul Wahab , Ridha Syahrul , Yunus Muhammad , Kamil Puspita Annaba , Safiah Intan , Gadeng Ahmad Nubli
Published: January 2022

The Covid-19 pandemic almost stalled the face-to-face learning method in all institutions across the globe. Consequently, for learning to continue uninterrupted, there was a need to change teaching mode to online using social media and other platforms. This research aimed to examine the effectiveness of online learning during the Covid-19 pandemic and the challenges geography students faced in implementing this type of study. The research used a descriptive qualitative approach involving questionnaires designed to determine the implementation of online learning and the challenges encountered. The questions were structured through synthesizing various components of learning. Random selection was used to select 305 participants from various higher education institutions in the Aceh Region, Indonesia. The results indicated that online learning during the Covid-19 pandemic was effectively implemented. However, some challenges were encountered, including students who could not fully participate since they could not log in to the provided learning platforms. Furthermore, students from rural areas had poor internet connectivity besides the inability to buy internet quota. There were many instances of reported power supply failures, and this hindered online learning. Overall, learning geography during the pandemic was effective, though it had a fair share of challenges. The research also identified the need to develop an online learning model, teaching material, and multimedia in supporting geography-based online learning.    

Keywords: Assessing; Effectiveness; Geography-based online learning; Covid-19; Higher education

Copyright (c) 2021 Geosfera Indonesia and Department of Geography Education, University of Jember

 

 

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