bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of influence of aircraft propeller modal parameters on small airplane performance
Authors: Kilikevičius Arturas , Rimša Vytautas , Rucki Mirosław
Published: December 2019

The aim of the current paper is to investigate a small airplane model propeller of class F2D according to requirements of Fédération Aéronautique Internationale (FAI, or World Air Sports Federation). In some cases, practical tests show that F2D models with
flexible propellers produce specific extra noise and increase flight speed in comparison with “rigid” propellers. Therefore, the
following hypothesis could be proposed: flexible characteristics of the increased noise are related to the resonant eigenfrequencies
of the propeller. The operating range of the F2D class propeller (28,000-35,000 rpm) is close to or equal to the eigenfrequency
resonance. The current investigation addresses dynamic/flexible vibrations of elastic propeller during engine run and researches
dynamic parameters of the propeller as well as the contribution of these parameters to the model flight characteristics. To resolve
this type of a problem, a stand, which allows completing a physical investigation of flexible propeller vibration modes and dynamic
characteristics was created.
An aggregate criterion for selecting a distribution for times to failure of components of rail vehicles
Authors: Selech Jarosław , Andrzejczak Karol
Published: December 2019

This paper presents an aggregate method of selecting a theoretical cumulative distribution function (CDF) for an empirical CDF.
The method was intended to identify the time of reliable operation of a renewable technical object by applying three criteria based
on the following statistics: the modified Kolmogorov–Smirnov (MK-S) statistic, the mean absolute deviation of the theoretical
CDF from the empirical CDF, and a statistic calculated on the basis of a log-likelihood function. The values of these statistics
were used to rank eleven probability distributions. The data for which calculations were made concerned failures of the driver’s
cab lock recorded during five years of operation of a fleet of 45 trams. Before calculating the statistics, the empirical CDF of the
examined component was determined using the Kaplan–Meier estimator, and then, using the method of Maximum Likelihood Estimation, the parameters of the analysed theoretical distributions were estimated. The theoretical distributions were then ranked
according to the values obtained for each of the assumed criteria: the lower the value for a given criterion, the higher the ranking
position, indicating a better fit according to that criterion. Then, based on the three rankings and on weights assigned to the individual criteria, an aggregate criterion (referred to as DESV) was implemented to select the best-fitting probability distribution.
The method assumes that the lowest DESV value corresponds to the best-fitting theoretical distribution. In the case of the examined
component, this was found to be the generalised gamma distribution. It is shown that if the final decision is based on the aggregate criterion, which takes into account the three criteria for goodness of fit, the reliability of the estimation of the time-to-failure
distribution increases, and thus mistakes resulting from the use of only one of the criteria can be avoided.
Reliability estimation for momentum wheel bearings considering frictional heat
Authors: Huang Hong-Zhong , Yu Kang , Huang Tudi , Li He , Qian Hua-Ming
Published: December 2019

Momentum wheels are the key components of the inertial actuators in the satellites, and the momentum wheel bearings are weak
links of momentum wheels as they operate under harsh conditions. The reliability estimation for momentum wheel bearings are
helpful to guarantee the mission successes for both momentum wheels and satellites. Hence, this paper put emphasis into reliability estimation of a momentum wheel bearing considering multiple coupling operating conditions and frictional heat by using
the finite element analysis. The stress-strength interference model is employed to calculate the reliability of the momentum wheel
bearing. A comparative analysis for reliability estimation with and without frictional heat of the momentum wheel bearing is conducted. The results show that the frictional heat cannot be ignored in the reliability analysis of momentum wheel bearings
Reliability analysis of a multi-eso based control strategy for level adjustment control system of quadruped robot under disturbances and failures
Authors: Cui Jingjing , Ren Yi , Xu Binghui , Yang Dezhen , Zeng Shengkui
Published: December 2019

The complexity of control algorithms and their vulnerability to disturbances and failures are the main problems that restrict the
operations of multi-legged mobile robots in more complex environments. In this paper, a multiple extended state observer (ESO)
based control strategy is proposed to achieve stable tilt angle control for quadruped robots under the influence of disturbances
and actuator failures. By treating the multiple legs as parallel control objects, more ESOs were added to improve the disturbance
rejection ability of the linear active disturbance rejection control (LADRC). Correlation of interactive information about the legs
is realized by the synthesis of multiple ESO information. Based on LADRC, this method has the advantages of easy parameter
tuning, good robustness, and strong ability to cope with interference and fault conditions. A control system reliability evaluation
method was proposed. The reliability and control performance of the multi-ESO based control system under leg stuck failure conditions were systematically analyzed. Simulation and experimental results for the level adjustment control system of a quadruped
robot are provided to verify the disturbance rejection ability, feasibility and practicability of the proposed multi-ESO based control
method
Modified convolutional neural network with global average pooling for intelligent fault diagnosis of industrial gearbox
Authors: Li Yaxin , Wang Kesheng
Published: December 2019

Gearboxes are key transmission components and widely used in various industrial applications. Due to the possible operational
conditions, such as varying rotational speeds, long period of heavy loads, etc., gearboxes may easily be prone to failure. Condition
Monitoring (CM) has been proved to be an effective methodology to improve the safety and reliability of gearboxes. Deep learning
approaches, nowadays, further enable the CM with more powerful capability to exploit faulty information from massive data and
make intelligently diagnostic decisions. However, for most of conventional deep learning models, such as Convolutional Neural
Network (CNN), a large amount of labelled training data is a prerequisite, while to obtain the labelled data is usually a laborious and time-consuming job and sometimes even unattainable. In this paper, to handle the case of only a limited labelled data is
available, a modified convolutional neural network (MCNN) is proposed by integrating global average pooling (GAP) to reduce
the number of trainable parameters and simplify the architecture of deep learning model. The proposed MCNN improves the traditional CNN’s ability in fault diagnosis with limited labelled data. Two experimental gearbox datasets are utilized to demonstrate
the effectiveness of the proposed MCNN method. Compared with traditional deep learning approaches, namely LSTM, CNN and
its variant methods, the experimental results show that the proposed MCNN with higher discrimination and generalization ability
in fault classification and diagnostics under the scenario of limited labelled training samples
The effect of three-component antihypertensive treatment on the structural and functional state of the heart and daily blood pressure profile in patients with hypertension grade 3
Authors: Azaeva N R
Published: December 2019

Aim. To study the effect of a fixed combination of perindopril arginine (10 mg) + indapamide (2.5 mg) + amlodipine (5 mg) on the daily profile of blood pressure and the structural and functional state of the heart in patients with hypertension grade 3.

Methods. 80 patients with hypertension receiving various variants of treatment [50 patients (experimental group) receiving fixed combination of perindopril arginine (10 mg) + indapamide (2.5 mg) + amlodipine (5 mg) and 30 patients (control group) receiving combination of lisinopril with hydrochlorothiazide (10/12.520/25 mg) and amlodipine (5 mg)] underwent electrocardiography, Doppler echocardiography, daily monitoring of blood pressure at there points: at the beginning, after 2 weeks and 6 months of the treatment. Statistical significance of the indicators was determined by Students t-test. To compare the double changes, 2 was used. Statistical difference between the groups was considered significant if p 0.05.

Results. In 86% of patients from the experimental group, a decrease in systolic blood pressure by 20 mm Hg or more and/or diastolic blood pressure by 10 mm Hg was noted, which persisted for 6 months. After 6 months of treatment, according to daily monitoring of arterial pressure, the average daily systolic and diastolic blood pressure significantly decreased by 15.9 and 18.6% (р 0.001), and the values of variability of average systolic and average diastolic pressure at night and daytime by 4 and 4.2%, respectively (р 0.001). A decrease in the morning rise rate of systolic and diastolic blood pressure was also achieved (р 0.001). During treatment, a number of patients with a daily curve of the dipper type increased due to a decrease in non-dippers and night pickers (р 0.001).

Conclusion. Positive antihypertensive result after treatment with a combination of perindopril arqinine + indapamide + amlodipin was achieved in the early stages of treatment and was observed as a long-term stable hypotensive effect; a number of patients with normal daily rhythm of blood pressure increased, decrease of the severity of hypertrophy and size of the left ventricle was observed and its diastolic function became normal.
Some approaches to dispanserization of patients with hypertensive disease at territorial internist's area
Authors: Babushkin I E , Gataulina O V , Demina E I , Bublikov D S , Duruda N V , Kudeyarova T V
Published: December 2019

Aim. To study creatinine clearance, body mass index and to perform ROSE survey amomg patients with hypertension of different age groups at territorial internist's area.

Methods. The study involved 112 patients aged 40 to 75 years. Patients were divided into two groups according to the age: group 1 40 to 61 years, 55 people (15 men and 40 women), the average age 52.67.1 years; group 2 62 to 75 years, 57 people (15 men and 42 women), the average age 69.84.4 years. Creatinine clearance and body mass index were measured, and ROSE survey was conducted.

Results. In group 1 creatinine clearance 60 ml/min was in 5 (9%) subjects, in group 2 in 20 (35%; p=0.002). In group 1 15 (27%) subjects had normal body mass, in group 2 5 (9%). In group 1 overweight was registered in 18 (33%) subjects, and in group 2 in 24 (42%; p=0.407). Class I obesity in group 1 was found in 15 (27%) patients, in group 2 in 16 (28%; p=0.907). Class II obesity in group 1 was noted in 5 (9%) patients, in group 2 in 4 (7%; p=0.955). Class III obesity in group 1 was registered in 2 (4%) people and in 8 (14%) in group 2 (p=0.110). According to the results of ROSE questionnaire, signs of angina pectoris were found in 7 (13%) patients in group 1 and 17 (30%) in group 2 (p=0.048).

Conclusion. In the territorial internist's area the proportion of cases of overweight and obesity among patients of groups 1 and 2 with hypertension did not differ significantly (p 0.05); in patients from group 2 with hypertension creatinine clearance less than 60 ml/min was identified 3.9 times more often than in the younger age group (p=0.002); in patients of group 2 with hypertension were 2.3 times more likely to have angina, according to ROSE questionnaire than in group 1 (p=0.048).
Modern problems of organizing vaccination of children in children's clinics
Authors: Alekseeva Anna Vladimirovna
Published: December 2019

Aim. To study the problems of organizing vaccination of children in children's clinics to develop measures aimed at increasing the coverage of children with vaccination.
Methods. On the basis of 7 children's polyclinics in Saint Petersburg, an anonymous survey of 1724 mothers who had children aged 1 year was carried out by random sampling according to a specially developed form Questionnaire for a mother of a child aged one year. The representativeness of this sample was tested by professor A.M. Merkova's method, the error did not exceed 2.2%.
Results. 15.7% of children had violations of the vaccination status, 4.9% of them were not completely vaccinated. The main reason for refusal from vaccination in 89.8% of cases with partial vaccination and in 82.5% of cases with complete refusal was medical contraindications related to the childs state of health. The most common causes of vaccination against individual childhood infections (partial vaccination) were the belief that there is no danger of infection with childhood infectious diseases (81.3%) and the fear of possible post-vaccination complications (69.7%). Parents completely refused vaccinations most often because of doubts about the quality of vaccines (74.4%) and fear of possible post-vaccination complications (66.7%). 69.5% of parents whose children were vaccinated in the first year of life did not receive complete information from the doctor about the vaccine and the disease that the child will be vaccinated with, as well as the possible consequences of immunization. In 76.6% of partially and completely vaccinated children, immunization was not organized in accordance with the guidelines. At the same time, in 49.1% of them, the health worker specified the information about the state of health after vaccination by phone call the day after immunization, and 1.7% of children had no follow-up after vaccination.
Conclusion. The organization of vaccine prophylaxis in children's clinics has a significant number of unresolved problems, which can lead to a further decrease in the coverage of children with vaccination against vaccine-controlled infections.
Analysis of ultrasonic waves generated by oblique incidence of a laser
Authors: Saito O , Higuchi N , Sen E , Okabe Y
Published: December 2019

Laser ultrasonic waves are promising tools for non-destructive inspection in various industries. To inspect an entire object, the laser beam must scan the complete surface of the object. The incident angle of the laser beam will then differ depending on the location on the object that
is irradiated. While oblique incidence of the laser beam will excite ultrasonic waves, there is a possibility that these waves will be different from those excited at normal incidence. For the establishment of reliable inspection techniques, a deeper understanding of laser ultrasonic waves
is required. In this paper, the generation of ultrasonic waves by lasers at oblique incidence is numerically investigated. An integral expression for the temperature distribution that satisfies the thermal conduction is derived and then finite element method (FEM) simulations of the generated
elastic waves are performed. In the case of a small incident angle of the laser beam, the directional dependence of the generated ultrasonic waves is small. However, with a large incident angle, the generated waves exhibit directionality in the wave intensity. Although the incident angle does
not need to be considered in the ordinary use of laser ultrasonic devices, the detectability of defects may be affected when the angle is very large.
Elucidation of magnetic flux leakage for welding defect detection at different magnetic field directions through alternating magnetic field measurement
Authors: Gao Xiangdong , Dai Xinxin , Zhou Xiaohu , Li Yanfeng , You Deyong , Zhang Yanxi , Zhang Nanfeng
Published: December 2019

Alternating current field measurement (ACFM) is a technology for detecting magnetic flux leakage (MFL) using a magnetic sensor and is often used to detect welding defects. An alternating magnetic field was generated under the excitation of an alternating electric field. The magnetic
field direction of an alternating magnetic field changes with time and the size and direction of the leakage magnetic field on the weldment also change periodically. In order to verify this rule, the distribution of the leakage magnetic field in different magnetisation directions was analysed
through simulation and experiment. The simulation results show that when sinusoidal excitation is applied to the coil, the direction of magnetisation changes with time and the magnetic field density (B) gradually changes periodically on the weldment. This was verified through related experiments.
When the surface of the weldment had welding defects, the dynamic magneto-optical image was captured in different magnetisation directions. Welding defects have different magneto-optical images in different frames, which can present more information for the same defect. In addition, in the
experiment, the correlation between the grey-level co-occurrence matrix (GLCM) of magneto-optical images in different magnetisation directions and that of the leakage magnetic field in the corresponding direction was analysed. Simulations and experiments were performed on different types of
welding defect. It was found that the trend of characteristics for the leakage magnetic fields was similar to that of the characteristics for the grey-level co-occurrence matrix of the magneto-optical images. The results show that the characteristics of the leakage magnetic field can reflect
the texture features of the welding defect.
Imaging a weld cross-section using a novel frequency feature in multi-frequency eddy current testing
Authors: Xu Hanyang , Lu Mingyang , Avila J R Salas , Zhao Qian , Zhou F , Meng Xiaobai , Yin Wuliang
Published: December 2019

In this paper, a novel frequency feature (the frequency at which the real part of the inductance reaches a specified value) is proposed for imaging an X70 welding cross-section. It is derived that this frequency feature is related to the permeability of the sample and therefore the
imaging results obtained from this feature are a reflection of the electromagnetic properties (in particular permeability) map of the sample. The resulting images are then compared with the weld macrograph and the hardness map. The shape and contour of three weld zones (fusion zone, heat-affected
zone and base metal) can be identified. This novel imaging method has a high sensitivity to changes in microstructure and, by adjusting the inductance value it crosses, the frequency range can be adjusted to suit the capability of a particular instrument.
THEORETICAL AND EXPERIMENTAL INFRARED SPECTRUM ANALYSIS OF 1-ETHYL-3-METHYLIMIDAZOLIUM CATION
Authors: KUŞ Nihal , ILICAN Saliha
Published: December 2019

In this study, molecular structure of
1-ethyl-3-methylimidazolium cation (EMIM+) was undertaken at the
DFT(B3LYP)/6-311++G(2d,2p) level of approximation using the GAUSSIAN 09 suit of
programs. EMIM has two conformers (EMIM-1 and EMIM-2) with minimum energies.
EMIM-1 and EMIM-2 were found C1 (double degenerated by-symmetry form) symmetry.
Normal coordinate analyses were performed with the BALGA program. Experimental
infrared spectra of EMIM were obtained by increasing temperature (between room
temperature and 150oC) and compared with calculations. Assignment of
the spectra and normal coordinate analyses to characterize the vibrations in
EMIM conformers were undertaken. p-electron delocalization through the
aromaticity index Harmonic Oscillator Measure of Aromaticity (HOMA) of EMIM
calculated using Kruszewski and Krygowski definations.
SMART GRID INTEGRETED WITH HYBRID RENEWABLE ENERGY SYSTEMS
Authors: AYDIN Ömer , DEMİR Zafer
Published: December 2019

The growing world population and
fossil fuel reserves have been aimed at alternative searches as energy sources
due to a decreasing curve. The rate of formation of Fossil fuels does not
exhibit a parallel formation of the amount of consumption according to the
years. Nowadays, no matter how many alternative suggestions are revealed, there
is no way to choose them yet. Despite the use of fossil fuels such as coal, oil
and natural gas in energy production, the rapid depletion of these resources
has increased the direction of us to renewable energy sources. The key
advantage of renewable energy sources is the ability to create a hybrid system
with other energy sources. Hybrid systems allow the combined use of different
energy sources and the integration of renewable energy sources into the
existing system. This study provides examples of hybrid renewable energy
systems and information on how to integrate into existing systems. One of the
most important applications to increase the use of renewable energy resources
is the systems that are used together with different energy sources and are
called hybrids. Today, it has become mandatory to analyze various working
conditions as well as in large power systems of renewable energy-induced hybrid
systems that are widely used.
Retro rectus mesh repair for umbilical hernia in adults: a study of 50 cases
Authors: Vagholkar Ketan
Published: December 2019

Background: Umbilical hernia is one of the most commonly encountered hernia in surgical practice. A variety of repairs have been tried our ranging from open to laparoscopic. However controversy still persists as to which type of repair is the gold standard for umbilical hernia. Open technique comprises of the onlay mesh repair which is known to develop a variety of complications. Even laparoscopic approach also has failure rates as well as local complications. The aim of the study was to evaluate the surgical outcome of open retro rectus mesh repair for adult umbilical hernias.Methods: 50 consecutive cases of umbilical hernia were repaired by open technique with retro rectus placement of mesh.Results: There were no local complications or any recurrence in any of the fifty patients.Conclusions: Retro rectus placement of mesh in open repair of umbilical hernia in adults is a safe and effective modality of treatment.
Correlation between nasal endoscopy and computed tomography in a tertiary care hospital
Authors: Sriprakash Vinnakota , Sisodia Shalini Singh
Published: December 2019

Background: Chronic rhinosinusitis is associated with morbidity and affects the quality of life of the affected persons and increases their treatment costs. Diagnosis is mainly by nasal endoscopy or by computed tomography which is considered to be the gold standard.

Methods: Nasal endoscopy was done for all the patients under local anaesthesia. All the patients also underwent computed tomography and paranasal sinuses and the findings were scored according to Lund Mackay scoring system.  

Results: The most common age group was 31-40 years and nasal discharge was the most common symptom seen in 82% of the patients. The paranasal sinuses that were involved were predominantly maxillary sinus in a total of 88% of the patients. 22% of the patients have sinusitis in the anterior ethmoid of the left nose and 20% on the right nose. Bilateral was seen in 22% of the cases. The sensitivity of nasal endoscopy over computed tomography was 95.6% while the specificity was 80%. The positive predictive value was 97.7% and the negative predictive value was 66.7%. The accuracy of the test was 94%.

Conclusions: Nasal endoscopy is found to be as good as the computed tomography for the diagnosis of chronic rhinosinusitis and can be used on a regular basis for its detection among the patients. It not only lacks radiation but is also economically viable.
Investigation of combustion and emission in a DI diesel engine fueled with hydrogen-biodiesel blends
Authors: CİHAN Ömer , TEMİZER İlker
Published: December 2019

The aim of this study was to determine the availability of canola oil methyl ester as an alternative fuel in diesel engines and by adding canola oil methyl ester and hydrogen to diesel fuel. This study was carried out experimentally and numerically. The engine was studied at 2000 rpm speed and full load. The analyzes carried out in the AVL-FIRE ESE Diesel part. In-cylinder combustion and emission analyzes were examined experimentally by adding 10% (B10) and 20% (B20) of the canola oil methyl ester to the diesel (D100) fuel. Also, hydrogen fuel by the amount of 3% and 6% of the mass were added to diesel and biodiesel mixture fuels to eliminate some disadvantages of biodiesel fuels. The obtained findings in experimental and numerical studies were similar to each other. The similarity of these results was also validated by numerical studies using hydrogen. The boundary conditions obtained in experimental studies were determined, and the effect of hydrogen fuel on temperature, in-cylinder pressure, spray distribution and CO formation were examined numerically. In the experimental studies conducted with D100, B10 and B20 fuels, the maximum pressures in-cylinder were measured as 87 bar, 88 bar and 89.09 bar respectively. In numerical results, these values were recorded as 90.02, 90 and 93.8 bar respectively. Addition of 3% and 6% hydrogen to these three different fuel mixtures increased in-cylinder pressures and temperatures. Also, in-cylinder droplet diameters with the addition of hydrogen decreased in all test fuels. This situation led to a reduction in CO emissions.
Predicted fuel characteristics of prunus avium seed oil as a candidate for biodiesel production
Authors: ABDULVAHİTOĞLU Aslı
Published: December 2019

Energy is an indispensable requirement for both developed and developing societies today. However, most of the energy needs are met by fossil fuels, these resources are not renewable. Many countries are evaluating alternative sources to meet energy demand and to sustain development. In this study, oil was obtained by using Prunus avium kernels, also known as Turkish Cherry cultivated from Pozantı which is on the Taurus Mountains. Oil characterization was performed by gas chromatography (GC) and free fatty acids were determined. Oleic acid (C18:1) and Linoleic acid (C18:2) determined as 38.938 and 40.963 respectively. The free fatty acids were then evaluated using the Biodiesel Analyzer v1.2 program. The predicted results were the total percentage of monosaturated fatty acids (MUFA) 39.408, total percentage of polyunsaturated fatty acids (PUFA) 41.042, Allylic Position Equivalents (APE) 121.146, Bisallylic position equivalents (BAPE) 41.220 respectively. On the other hand, Long Chain Saturated Factor (LCSF) is calculated as 3.624. Higher Heating Value (HHV) was calculated as 37.65Mj/kg, Cloud Point (CP) 0.099, Cold Filter Plugging Point (CFPP) -5.091° C, Density (d) 0.838 (g/cm3), Cetane Number (CN) 50.1, Iodine Value (IV) 109.878, Kinematic Viscosity 3.543, Flash Point (FP) 160.56, Saponification Value (SV) 191.354, and Oxidation Stability (OS) 5.468, respectively. As a result of this study, it was concluded that Prunus Avium kernel oil is a promising biodiesel candidate.
Myosins and pathology: genetics and biology.
Authors: Redowicz Maria Jolanta
Published: December 2019

This article summarizes current knowledge on the genetics and possible molecular mechanisms of Human pathologies resulted from mutations within the genes encoding several myosin isoforms. Mutations within the genes encoding some myosin isoforms have been found to be responsible for blindness (myosins III and VIIA), deafness (myosins I, IIA, IIIA, VI, VIIA and XV) and familial hypertrophic cardiomyopathy (beta cardiac myosin heavy chain and both the regulatory and essential light chains). Myosin III localizes predominantly to photoreceptor cells and is proved to be engaged in the vision process in Drosophila. In the inner ear, myosin I is postulated to play a role as an adaptive motor in the tip links of stereocilia of hair cells, myosin IIA seems to be responsible for stabilizing the contacts between adjacent inner ear hair cells, myosin VI plays a role as an intracellular motor transporting membrane structures within the hair cells while myosin VIIA most probably participates in forming links between neighbouring stereocilia and myosin XV probably stabilizes the stereocilia structure. About 30% of patients with familial hypertrophic cardiomyopathy have mutations within the genes encoding the beta cardiac myosin heavy chain and both light chains that are grouped within the regions of myosin head crucial for its functions. The alterations lead to the destabilization of sarcomeres and to a decrease of the myosin ATPase activity and its ability to move actin filaments.
Hydrolysis of cyclic GMP in rat peritoneal macrophages.
Authors: Witwicka Hanna , Kobiałka Marcin , Gorczyca Wojciech A
Published: December 2019

Intact rat peritoneal macrophages (rPM) treated with 3-isobutyl-1-methylxanthine (IBMX), an inhibitor of phosphodiesterases (PDEs), accumulated more cGMP than untreated cells. A PDE activity toward [(3)H]cGMP was detected in the soluble and particulate fractions of rPM. The hydrolysis of cGMP was Ca(2+)/calmodulin-independent but increased in the presence of cGMP excess. Similar results were obtained when [(3)H]cAMP was used as a substrate. The hydrolytic activity towards both nucleotides was inhibited in the presence of IBMX. Therefore, the PDEs of families 2, 5, 10 and 11 are potential candidates for cGMP hydrolysis in the rPM. They may not only regulate the cGMP level in a feedback-controlled way but also link cGMP-dependent pathways with those regulated by cAMP.
Protective role of L-methionine against free radical damage of rat brain synaptosomes.
Authors: Slyshenkov Vyacheslav S , Shevalye Anna A , Liopo Anton V , Wojtczak Lech
Published: December 2019

Incubation of rat brain synaptosomal/mitochondrial fraction with tert-butylhydroperoxide resulted in accumulation of the lipid peroxidation product, conjugated dienes, damage of the synaptosomal membrane as evidenced by leakage of lactate dehydrogenase, and decrease of the total content of glutathione and of the GSH/GSSG ratio. This treatment also produced a considerable decrease of the ouabain-sensitive ATPase activity and a much smaller diminution of the activities of glutathione reductase and glutathione transferase. Preincubation of the synaptosomal/mitochondrial fraction with 0.5 or 1.0 mM L-methionine significantly protected against lipid peroxidation, membrane damage and changes in the glutathione system produced by low (1 mM) concentrations of tert-butylhydroperoxide and completely prevented inactivation of ouabain-sensitive ATPase, glutathione reductase and glutathione transferase by such treatment. The importance of L-methionine in antioxidant protection is discussed.
Effect of natural phenols on the catalytic activity of cytochrome P450 2E1.
Authors: Mikstacka Renata , Gnojkowski Jerzy , Baer-Dubowska Wanda
Published: December 2019

The effect of protocatechuic acid, tannic acid and trans-resveratrol on the activity of p-nitrophenol hydroxylase (PNPH), an enzymatic marker of CYP2E1, was examined in liver microsomes from acetone induced mice. trans-Resveratrol was found to be the most potent inhibitor (IC(50) = 18.5 +/- 0.4 microM) of PNPH, while protocatechuic acid had no effect on the enzyme activity. Tannic acid with IC(50) = 29.6 +/- 3.3 microM showed mixed- and trans-resveratrol competitive inhibition kinetics (K(i) = 1 microM and 2.1 microM, respectively). Moreover, trans-resveratrol produced a NADPH-dependent loss of PNPH activity, suggesting mechanism-based CYP2E1 inactivation. These results indicate that trans-resveratrol and tannic acid may modulate cytochrome P450 2E1 and influence the metabolic activation of xenobiotics mediated by this P450 isoform.
Mouse cytosolic acetyl-CoA hydrolase, a novel candidate for a key enzyme involved in fat metabolism: cDNA cloning, sequencing and functional expression.
Authors: Suematsu Naoya , Okamoto Kazuki , Isohashi Fumihide
Published: December 2019

A cytosolic acetyl-CoA hydrolase (CACH) cDNA has been isolated from mouse liver cDNA library and sequenced. Recombinant expression of the cDNA in insect cells resulted in overproduction of active acetyl-CoA hydrolyzing enzyme protein. The mouse CACH cDNA encoded a 556-amino-acid sequence that was 93.5% identical to rat CACH, suggesting a conserved role for this enzyme in the mammalian liver. Database searching shows no homology to other known proteins, but reveals homological cDNA sequences showing two single-nucleotide polymorphisms (SNPs) in the CACH coding region. The discovery of mouse CACH cDNA is an important step towards genetic studies on the functional analysis of this enzyme by gene-knockout and transgenic approaches.
Protein kinases CKI and CKII are implicated in modification of ribosomal proteins of the yeast Trichosporon cutaneum.
Authors: Wojda Iwona , Cytryńska Małgorzata , Frajnt Magdalena , Jakubowicz Teresa
Published: December 2019

Phosphorylation of acidic ribosomal proteins P1/P2-P0 is a common phenomenon in eukaryotic organisms. It was found previously that in Trichosporon cutaneum, unlike in other yeast species, in addition to the two acidic ribosomal proteins, two other proteins of 15 kDa and 19 kDa of the small ribosomal subunit were phosphorylated. Here we describe two protein kinases: CKI and CKII, which are engaged in the modification of T. cutaneum ribosomal proteins. The acidic ribosomal proteins and the protein of 19 kDa were modified by CKII associated with ribosomes, while the protein of 15 kDa was modified by CKI. Protein kinase CKI was purified from cell-free extract (CKIC) and from ribosomal fraction (CKIR). The molecular mass of CKIC was established at 33 kDa while that of CKIR at 35-37 kDa. A protein of 40 kDa copurified with CKIR but not CKIC. Heparin significantly increased 40 kDa protein phosphorylation level by CKIR. Microsequencing analysis revealed the presence of CKI recognition motifs in the N-terminal fragment of the 40 kDa protein.
Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells.
Authors: Nosach Lidiya , Dyachenko Nataliya , Zhovnovataya Valentina , Lozinskiy Miron , Lozitsky Victor
Published: December 2019

Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs epsilon-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.
ÉTICA NO FAZER PROFISSIONAL DA ENFERMAGEM: REFLEXÕES À LUZ DO PENSAMENTO DE HANNAH ARENDT
Authors: Biazus Dalcin Camila , Serpa Rafaela , Kotzias Atherino Dos Santos Evangelia , Vieira Tourinho Francis Solange , Kuerten Rocha Patricia
Published: December 2019

Objetivo: refletir sobre a ética no fazer profissional da enfermagem, levando em consideração os conceitos de condição humana e a banalidade do mal de Hannah Arendt. Método: reflexão teórico-filosófica. Resultados: o pensamento crítico reflexivo deve ser parte do fazer profissional da enfermagem, para que seja aceita a condição humana – o labor, o trabalho e a ação – da ética no cuidado, evitando, assim, fragmentações, erros e mecanização do cuidado de enfermagem. A banalidade do mal pode ser transposta por meio da educação permanente e continuada do profissional de enfermagem. Conclusão: ao utilizar conceitos do pensamento de Hannah Arendt, percebe-se a importância de que o profissional da enfermagem assuma uma postura crítico-reflexiva e ética de não julgamento, destacando-se que a educação em saúde, trabalho em equipe e sentimento de pertencimento à profissão de enfermagem, são elementos importantes para o fortalecimento profissional.
Descritores: Ética. Ética em Enfermagem. Prática Profissional. Filosofia em Enfermagem. Ética Profissional. Cuidados de Enfermagem
Consumo, estética, técnica e religião em Cloaca, de Wim Delvoye
Authors: Ferraz Vidal Junior Icaro
Published: December 2019

Cloaca (2000-2010), de Wim Delvoye, consiste em um conjunto de máquinas desenvolvidas para produzir “merda real industrializada” em museus e galerias de arte. Após descrição sumária da série, desdobramos nossa análise em três eixos: o primeiro baseado na  articulação psicanalítica entre merda e dinheiro; o segundo na diferenciação formulada geneticamente por Gilbert Simondon (1989) entre estética, técnica e religião; e o terceiro no conceito de máquina, formulado por Gilles Deleuze e Félix Guattari (1972). Por fim, comparamos Cloaca e Anal Kisses (2011), projeto do mesmo artista, e buscamos identificar alguns vetores culturais que incidiram na recepção desigual dos dois projetos.
Disputas discursivas, legitimação e desinformação: o caso Veja x Bolsonaro nas eleições brasileiras de 2018
Authors: Recuero Raquel da Cunha
Published: December 2019

O presente artigo foca na temática das disputas discursivas que ocorreram no Twitter durante a campanha eleitoral presidencial de 2018, particularmente no caso da matéria publicada pela Revista Veja no dia 28 de setembro, onde a mesma relatava o processo de divórcio do candidato do PSL, Jair Bolsonaro. Neste, acusações de corrupção e violência eram explícitas. Os resultados mostram que a disputa se deu, principalmente, entre os veículos noticiosos e a militância apoiadora do candidato. Além disso, o discurso anti-Veja que se sucedeu à matéria utilizou estratégias de legitimação baseadas em moralidade e desinformação para contrapor os danos.
Na superfície lisa da história: a imprensa e as formas clandestinas de informação
Authors: Barbosa Ramsés Albertoni , Musse Christina Ferraz
Published: December 2019

O artigo investiga as estratégias utilizadas pelos presos políticos ligados ao Grupo Colina, detidos na Penitenciária de Linhares, em Juiz de Fora, para denunciarem os crimes cometidos pelos militares e resistirem ao regime ditatorial, no Brasil, durante as décadas de 1960 e 1970. A reconstrução histórica foi possível por meio do arquivo de documentos oficiais que comprovam o que se tentou silenciar. Dessa forma, a análise procurou compreender as contradições desses documentos que refletem as atividades que lhes deram origem, pois foram produzidos na vigência de regimes de exceção. A pesquisa se articula em duas frentes complementares, História e Comunicação, cujas “afinidades eletivas” concernem à reflexão acerca das instâncias de interlocução, aos limites e às possibilidades do diálogo entre duas epistemologias.
O monstro que não se vê e a cultura da participação em Bird Box
Authors: Ceretta Fernanda Manzo , Anaz Silvio Antônio Luiz
Published: December 2019

Bird Box, filme de terror e um dos maiores sucessos da Netflix, tem entre os protagonistas um monstro cuja imagem não é revelada. Tal estratégia narrativa resulta em amplo engajamento da audiência, que busca preencher a lacuna deixada no processo de criação do filme. Neste artigo, analisamos como a construção da ideia do monstro se dá também por meio de recursos não visuais, sobretudo sonoros, e é complementada por um imaginário que explora o tema do apocalipse, a metáfora da cegueira e a oposição arquetípica claro-escuro. A investigação fundamenta-se nas relações imagem-som propostas por Altman e Iazzetta e na teoria do imaginário de Durand. Os resultados mostram como esses elementos fomentam o engajamento da audiência, convergindo para a ideia de cultura da participação de Jenkins.
Keseimbangan Badan dan Jiwa Perspektif Abu Zaid Al-Balkhi
Authors: Musfihin Musfihin
Published: December 2019

Abu Zaid al-Balkhi was a multi-talent scientist in 9th-century Islam in several fields, his ability to write two themes in a systematic work had brought him to be known as the first mental health pioneer who before that time prioritized physical health. The purpose of this study is to describe the concept of Body and Soul according to Abu Zaid al-Balkhi, using the Research Library method from the data of Abu Zaid al-Balkhi's work entitled "Mashalih al-Abdan wal-Anfus" and from other sources related to research. This study found 2 (two) topics, among others: 1. The importance of maintaining body and soul health, namely body health as in general principles of health science such as maintaining environmental health, shelter, water, and air sanitation, while for mental health the importance of preserving mind and feelings, 2. Differentiation of treatment/treatment in dealing with neurosis and psychosis disorders, for neurotic disorders the therapeutic process is carried out with cognitive therapy while for psychosis disorders the therapeutic process is done spiritually, thus the importance of maintaining a balance of body and soul for health, otherwise imbalance will cause disease.
Análisis de la normatividad de países suramericanos relacionada con los derechos de propiedad intelectual aplicables a medicamentos
Authors: Machado Beltrán Manuel , Núñez Rocha Hernán , Acosta Ángela
Published: December 2019

El presente trabajo presenta una revisión que identifica diversos mecanismos jurídicos y comerciales utilizados actualmente con el fin de mantener condiciones favorables de mercado para determinados productos farmacéuticos. Mediante una consulta exhaustiva de información tanto a diversas autoridades nacionales de los países de Suramérica como a información publicada, se establece el estado actual normativo en ámbitos relacionados con la exclusividad de mercados otorgada a los medicamentos vía patentes y otras vías; el análisis de esta descripción se realiza a la luz de pautas de salud pública formuladas e implementadas en varios de los países de la región.
Amateur sport and emotional burnout formation in high school students
Authors: Tukaiev Sergii , Dolgova Olena , Lysenko Olena , Fedorchuk Svetlana , Havrylets Yurii , Rizun Volodymyr , Vasheka Tatyana , J. M. van den Tol Annemieke
Published: December 2019

Practicing sports, as well as physical activity in general, contributes to a healthy lifestyle, helps to prevent numerous chronic diseases, and plays a therapeutic role in addressing a number of cognitive and psychological disorders (such as depression, distorted body image and self-perception, low self-esteem). As regards students, freshmen with higher physical capabilities can better adapt to new college environment, which in turn influences their well-being, psychological state and ability to study. The aim of our study was to detect the level of emotional burnout and individual psychological characteristics of the university students, engaged in amateur sports. It was shown that the group of amateur sportsmen demonstrated higher level of arousal and mobility of neural processes, and lower level of neuroticism, lower level of neurotization, anxiety, psychic tension and depression. This allows us to conclude that the type of nervous system may define the disposition towards the physical activity, and the strength of nervous system determines the ability to achieve success in sports. Our data indicate that practicing sports prevents development of burnout, reduces the negative impact of daily emotional stress, and provides a socially acceptable way to express aggression.

Keywords: amateur sportsmen, typological and personality traits, burnout
Examining the motivations of primary school fourth grade students with regard to homework
Authors: Yildiz Vahit Aga , Kilic Durmus
Published: December 2019

In this study, the aim was to determine the motivation levels of primary school fourth grade students with regard to their homework, and whether their motivations differ in terms of some variables. The sample used in the study, conducted using a survey method, consists of 256 students studying in schools in the province of Erzurum of the Republic of Turkey. The data of the study were collected using a â€˜Homework Motivation Scaleâ€™. Data were analysed using descriptive statistical techniques, a t-test and a one-way analysis of variance test. It was seen that the internal and external motivations of the students differed with regard to intrinsic motivation. In addition, it was seen that students' autonomous motivations differed with regard to those who have someone who helps them with homework. Students' intrinsic motivation is higher than their external motivation. It is thought that this will contribute to students completing their homework successfully.

Keywords: Homework, motivation, primary school.
Analysis of communication styles between adolescents and parents (example of Kyrgyzstan)
Authors: Gokalp Murat
Published: December 2019

In this study, the aim was to determine the motivation levels of primary school fourth grade students with regard to their. The purpose of this study is to explain the forms of communication of adolescents with parents, problems in the school, sexual identities, conflicts with parents, how parents behave towards adolescents, the reasons of physical and mental changes experienced by adolescents and adolescents, to determine the anxiety and fear of adolescents and to reveal the expectations of parents from adolescents. The research was carried out in 2017â€“2018 academic year with 780 students, including 380 male, 400 female and 45 parents who have students in the same school.. According to the data obtained from the scale, the scores of girls were higher than males. Besides, the scores of the families with lower income were higher than the middle and upper groups.

Keywords: Adolescent, parent, adolescent communication, adolescent parent.
Culturas populares e novos contextos de performance no Brasil contemporâneo: o caso do Festival de Folclore de Olímpia
Authors: Reis Estêvão Amaro dos
Published: December 2019

Este trabalho propõe uma reflexão acerca do papel dos festivais de folclore no mundo contemporâneo. A partir de uma pesquisa etnográfica realizada no contexto do Festival do Folclore de Olímpia – Fefol – (São Paulo) e junto ao Pastoril Dona Joaquina de São Gonçalo do Amarante (Rio Grande do Norte), os festivais de folclore serão compreendidos como novos contextos de performance para as práticas dos grupos performativos das culturas populares brasileiras, também chamados de folclóricos nestes contextos. O Festival do Folclore de Olímpia é o maior evento do gênero no país, reúne anualmente quase uma centena de grupos folclóricos de todas as regiões brasileiras e é realizado há 55 anos ininterruptos. Fundado em 2006, com o intuito de renovar a tradição do pastoril no Rio Grande do Norte, o Pastoril Dona Joaquina participou do Fefol pela primeira vez em 2007. A reflexão empreendida terá como suporte teórico os conceitos discutidos por Etienne Wenger (2012) e Thomas Turino (2008).
AKILLI KENTLER ÜZERİNE BİR İNCELEME: TÜRKİYE ÖRNEĞİ
Authors: MİRGHAEMİ Seyed Amir
Published: December 2019

Günümüzde
gelişmiş ve gelişmekte olan tüm şehirler akıllı kent olma yolunda birbiri ile
yarışmaktadır. Her ne kadar henüz her yönüyle sürdürülebilir akıllı kent olarak
tanımlanabilecek bir şehir bulunmasa da, yapılan çabalar ümit vericidir. Tüm
dünya ile birlikte Türkiye’de de sürdürülebilirlik ve akıllı kent kavramları
önem kazanmış ve çeşitli uygulamalar başlatılmıştır. Ancak, Türkiye’deki akıllı
kentleşme çalışmalarının gelişmiş ülkelerle aynı seviyeye ulaşamadığı
görülmektedir. Bu çalışmada, Dünya ve Türkiye’de akıllı kentler ve sistemleri üzerine
bir inceleme yapılması amaçlanmıştır.
BÖLGESEL KALKINMA ÜZERİNE HAZIRLANAN LİSANSÜSTÜ TEZLERE YÖNELİK BİBLİYOMETRİK BİR ARAŞTIRMA
Authors: ÇELİKKAYA Süha , DEMİRGİL Hakan
Published: December 2019

Bibliyometrik araştırmalar aktardıkları bilimsel göstergeler ile yayın politikalarının belirlenmesinde bir dayanak noktasıdır. Bibliyometrik araştırmaların belirli süreçlerde tekrarlanması çalışmaya konu olacak alanın değerlendirilmesi açısından da önemlidir. Bu çalışmada YÖK ulusal tez merkezi veri tabanında yayımlanan bölgesel kalkınma alanında hazırlanmış lisansüstü tezler bibliyometri yöntemi ile analiz edilmiştir. Konu kapsamında bölgesel kalkınma ve bölgesel gelişme anahtar kelimelerini tez başlığında bulunduran lisansüstü tezler araştırılmıştır. Bu doğrultuda 1989-2019 yılları arasında çalışma konusu ile ilgili 269 adet lisansüstü tez tespit edilmiştir. Çalışmanın amacı bölgesel kalkınma ile ilgili tezlere ilişkin belirlenen parametreler çerçevesinde elde edilen bulguların sınıflandırılarak ortaya koyulması ve değerlendirmeler yapılmasıdır.