bluuebunny/crossref_metadata_2025 huggingface dataset:
Kinetics of glucose-6-phosphate dehydrogenase (G6PD) activity during Plasmodium vivax infection in French Guiana
Authors: DAHURON Laureen , GOUNGOUNGA Juste , DRAME Moustapha , DOUINE Maylis , NACHER Mathieu , BLAISE Théo , MOSNIER Emilie , MUSSET Lise , FOUILLET Marie , DJOSSOU Félix , EPELBOIN Loïc
Published: October 2023

Background: Plasmodium vivax is responsible for relapses through hepatic hypnozoites. To avoid these issues, we use primaquine, which is contraindicated in cases of glucose-6-phosphate-dehydrogenase (G6PD) deficiency. In French Guiana, G6PD activity is measured on day-14 of antimalarial treatment, to avoid misclassifying deficient patients in this hemolytic context. The aim of this study was to evaluate the kinetics of G6PD during a malaria attack to assess its variations over time.
Methods: This was a retrospective monocentric study. We collected G6PD activity between day-1 and day-28 in patients treated with chloroquine or artemisinin-based combination therapy (ACT) at Cayenne Hospital between January 2018 and December 2020. Patients were divided into 3 arms based on the number of available assessments of G6PD. The global group included arms 1, 2 and 3.
Findings: G6PD activity varied significantly over time (p = 0.004) and stabilized from day 3 onwards. None of the G6PD-deficient patients had false normal assays in the acute phase of the malaria attack. Conversely, we observed that patients with G6PD activity below 80% at D3 normalized at D14.
Sex and reticulocyte count were statistically associated with G6PD variation. Thirty patients (26.5%) were lost to follow-up before primaquine treatment. Among the 223 patients included in the global group, none had severe G6PD deficiency and only 3 (1.35% ± 0.78) had a deficiency between 10 and 30%.
Interpretation: G6PD activity varies over time during P. vivax attack. The G6PD value of the third day is reliable and could be used as a reference for primaquine administration. This could decrease early recurrences and reduce loss to follow-up before primaquine treatment. This proposition requires confirmation in larger prospective studies.
Exploration of clinical pathway practice for optimization of DRG costing results based on resource consumption
Authors: Wu Shu Qian , Wang Xiao Cui , Boyd Andrew D. , Feng Dan
Published: October 2023

In China, the reform of DRG parent method is in full swing, and how cost management to ensure efficient operation has become a difficulty in the process of hospitals "value" payment. Mengchao Hepatobiliary Hospital of Fujian Medical University used the cost accounting results to optimize the clinical pathway of DRG I311B,saving 44.56% in average, making the DRG I311B cost lower than the national level in a short time: based on the department cost accounting, the cost of medical service items was calculated according to the actual resource consumption, and the actual DRG cost data was calculated through the superposition of items.The calculation results are compared with DRG, and the difference data is obtained.The quality department determines whether the difference can be used to optimize the clinical path of the DRG, forming a continuously optimized double helix cost management model, which becomes an important decision-making method to help hospitals achieve clinical path management.
Follicular fluid-derived exosomes rejuvenate ovarian aging through miR-320a-3p-mediated FOXQ1 inhibition.
Authors: liu yu , mu hongbei , chen yu , li kexin , mei qiaojuan , wang lingjuan , tang tianyu , shen qiuzi , li huaibiao , zhang ling , li jing , xiang wenpei
Published: October 2023

Ovarian aging is mainly characterized by a progressive decline in oocyte quantity and quality, which ultimately leads to female infertility. Various therapies have been established to cope with ovarian aging, among which exosome-based therapy is considered a promising strategy that can benefit ovarian functions via multiple pathways. Here, we isolated and characterized exosomes derived from ovarian follicular fluid and profiled the differential expression patterns of noncoding exosomal RNAs in young and aged women. Exosomes can transfer their cargo miRNAs to granulosa cells, thus facilitating the interaction between somatic cells within the follicles and regulating the behavior of granulosa cells, eventually modulating ovarian functions. Furthermore, treatment with young mouse-derived exosomes efficiently rescued ovarian function in aged mice, which was achieved via transfer of miR-320-3p to granulosa cells and subsequent Foxq1 inhibition. This work provides insights into the antiaging potential of follicular fluid-derived exosomes and the underlying molecular mechanisms, which may facilitate prevention of ovarian aging and an improvement in female fertility.
Greedy Centroid Initialization for Federated $K$-means
Authors: Yang Kun , Amiri Mohammad Mohammadi , Kulkarni Sanjeev R.
Published: October 2023

In this paper, our focus is on $K$-means within a federated setting, where clients retain their raw data on local devices, and the raw data never leaves the corresponding devices.Given the importance of initialization on the federated $K$-means algorithm, our objective is to find better initial centroids by utilizing the local data stored on each client.To this end, we start the centroid initialization at the clients, rather than at the server, since the server initially lacks any preliminary insight into the clients' data. The clients first select their local initial clusters, and subsequently share their clustering information (including cluster centroids and sizes) with the server. The server then employs a greedy algorithm to determine the global initial centroids based on the information received from the clients. Numerical results obtained from both synthetic and public datasets demonstrate that our proposed method can achieve better and more stable performance than three distinct federated $K$-means variants, and comparable performance to the centralized $K$-means algorithm.
The generalized core-EP inverses involving projections in Banach *- algebras
Authors: Chen Huanyin , Abdolyousefi Marjan Sheibani
Published: October 2023

We investigate necessary and sufficient conditions under which the differences and products of two projections are generalized core-EP in-vertible. Then we present the representation of generalized core-EP inverse in a Banach *-algebra element by using related projections. Moreover, ex-pressions involving projections for the generalized core-EP inverse are given in a symmetric Banach *-algebra.
Kinetics of Bio-Hydrogen Production from Crude Glycerol by Locally Isolated Klebsiella pneumonia via Dark Fermentation
Authors: Haron Roslindawati , Alewi Nur Aizura Mat , Rahman Roshanida A. , Mat Ramli , Abdullah Tuan Amran Tuan
Published: October 2023

Bioconversion of crude glycerol (CG) to bio-hydrogen (Bio-H2) is promising because the capital investment and operation is cheaper. It is an environmentally friendly approach for waste reduction and clean energy production. However, the selection of microbes that can efficiently metabolise CG under anaerobic conditions is limited. This results in the low production and yield of Bio-H2. Hence, this study sought to examine a new indigenous bacteria (Klebsiella pneumoniae strain HS11286) that can consume CG and convert it into Bio-H2 without the need for pre-treatment or acclimatization. Dark fermentation was employed as it offers advantages in terms of the substrates and producers used. The research focused on the kinetic study for growth and substrate utilisation by kinetic model. In the metabolism of CG by K. pneumoniae, it needed 6 hours for lag phase to adapt to start proliferating and releasing Bio-H2, as well as the metabolites. Based on the HPLC results, three metabolites were produced during the metabolism of CG (i.e.: 1,3-propanediol, propionic acid, and ethanol). The kinetic analysis, and Bio-H2 production were estimated using the kinetic Monod model and the modified Gompertz equation. The kinetic analysis revealed a growth rate (µ) of 0.106 h− 1, glycerol consumption rate (Qgly) of 1.572 g/L/h, and the yield coefficients Yp/x, Yp/s, and Yx/s of 30,758.51 mL/g cell, 479.26 mL/g substrate, and 0.016 g cell/g substrate, respectively. The modified Gompertz model predicted Bio-H2 production of 10,155 mL at 620 mL/h with a 6 h lag period. In conclusion, K. pneumoniae strain HS11286 has the potential to produce almost 10 litre of hydrogen in a short period of time (less than 48 h) without substrate pre-treatment and bacteria acclimatisation or genetic engineering. This study highlighted that the K. pneumoniae strain HS11286 is a promising hydrogen-producer.
An Analysis of Energy Consumption in OECD Countries using Heterogeneous Dynamic Panel Models
Authors: Sevinç Adnan , Tatoğlu Ferda Yerdelen
Published: October 2023

This study aimed to determine the relationship between energy consumption, country income, and energy price in 11 OECD countries and used dynamic panel data models. There are several studies on energy with dynamic panel data models in the literature, but the results are biased because they ignore the heterogeneity of countries and cross-sectional correlation. In this study, the dynamic panel data model was extended to allow heterogeneity and cross-sectional dependency, and it was estimated with an instrumental variable that is seemingly unrelated regression and dynamic common correlated effects mean group estimators. Based on the estimation results and the theory, it was concluded that one lag of energy consumption and per capita income positively affect energy consumption, whereas energy price affects energy consumption negatively. The results of the model, which is created by including the common responses of countries to shocks and at the same time heterogeneous features from each other, and considering the effect of past experiences, will ensure that environmental policies are determined more accurately.
Unveiling the Promising Prognostic and Immunological Role of MRTO4 in Hepatocellular Carcinoma with Correlation to Immune Infiltrates
Authors: Zheng Yongyuan , Huang Yansong , Li Weibing , Cheng Hongqiu
Published: October 2023

Background
MRT4 Homolog, Ribosome Maturation Factor (MRTO4), is known to play a role in ribosomal biogenesis, a process that is often upregulated in cancer cells. However, its impact in hepatocellular carcinoma (HCC) and its correlation with immune infiltration is less well understood. Here, we explored the prognostic and immunological role of MRTO4 in HCC.
Methods
The primary dataset was sourced from The Cancer Genome Atlas (TCGA), GSE121248 and GSE45267and subjected to analysis through R software. MRTO4 expression was explored using the TCGA database, and correlations between MRTO4 and cancer immune characteristics were analyzed via the TISIDB databases.
Results
Generally, MRTO4 is predominantly overexpressed and has diagnostic and prognostic value in HCC. Upregulated MRTO4 was associated with poorer overall survival, poorer disease-specific survival, and progression-free interval. Mechanistically, we identified a hub gene that included a total of 50 MRTO4-related genes, which were tightly associated with Spliceosome pathways in HCC patients. MRTO4 expression was positively correlated with Th2 cells, NK CD56 + cells negatively correlated with the Th17 cells, NK cells, Neutrophils, DC cells, CD8 T cells and cytotoxic cells. MRTO4 expression was negatively correlated with the expression of immuno-stimulators (KDR, CD274, IL6R and TMEM173) and chemokines /chemokine receptors (CCL21, CXCL12, CCR4, and CX3CR1) in HCC.
Conclusion
MRTO4 may be used as a promising biomarker for determining prognosis in HCC. Furthermore, it might modulate tumor immunity in HCC by altering the expression of specific chemokines, chemokine receptors, and immunoinhibitory and immunostimulatory molecules, which correlated to immune infiltration.
Effect of long-term cervical extensor exercise program on functional disability, pain intensity, range of motion, cervical muscle mass and cervical curvature in young population with chronic non-specific neck pain: a randomized controlled trial
Authors: Zhang Yao , Lin Wancheng , Yi Meng , Yao Siyuan , Yao Mingtao , Luo Zhengning , Zhang Genai , Song Jipeng , Ding Lixiang
Published: October 2023

Background: There is growing popularity of chronic non-specific neck pain (CNNP) in young population. This study aimed to compare the effects of long-term specific cervical extensors training and stretching exercise on improving this chronic disorder in young population.
Methods: This is a prospective, randomized, controlled study. We assigned 70 young young participants, 18 to 35 years of age, who suffered CNNP and had loss of cervical lordosis, to undergo either specific cervical extensor training (observation group) or stretching exercise (control group). The duration of exercise was designed to be 12 months. Outcome assessment involved the changes in neck disability index (NDI), visual analogue scale (VAS) from baseline, cervical range of motion (CROM), cross-sectional areas (CSAs) of cervical extensors, and cervical curvature from baseline. The outcome measures were compared between groups at 3-, 6- and 12-month after follow-up.
Results: 70 participants underwent randomization. No significant difference of demographics and baseline data between the two groups was found. The observation group had greater improvement in NDI and VAS scores at 12-month follow-up than did the control group. Moreover, greater increase of CROM and CSAs of cervical extensors were found in observation group at 6-month and 12-month follow-up (P<0.05). More participants in the observation group obtained cervical lordosis at 12-month follow-up, however the difference was marginal, non-significant (P=0.07).
Conclusions: Among young population with CNNP, long-term specific cervical extensor training was associated with greater clinically meaningful improvement in disability, pain, and CROM. Increased CSAs of cervical extensors may potentially contribute to recovery of cervical lordosis.
Trial registration: The study is registered at the Chinese domestic clinical trial (ChiCTR2000040009) at Chictr.org.The date of registration: November 18, 2020.
Focal Chronic Inflammatory Demyelinating Polyneuropathy – Clinical application and validation of 2021 EAN/PNS criteria
Authors: Hiew Fu Liong , Paan Winnie Lee Mei
Published: October 2023

Background
The updated 2021 criteria of the European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) for chronic inflammatory demyelinating polyneuropathy (CIDP) has excellent diagnostic sensitivity and specificity for typical and variants CIDP. For focal monomelic CIDP, applications of this criteria may be different compared to typical or multifocal CIDP due to limited peripheral nerves involvement.
Case presentation
We illustrate using a rare case of focal right lower limb sensori-motor CIDP on the applicability of the 2021 EAN/PNS criteria and demonstrate the practical limitations of clinical, electrodiagnostic and supporting criteria in the diagnosis of focal CIDP. Unlike typical CIDP, diagnostic hallmark of classical proximal and distal weakness is frequently absent in focal CIDP. Therefore, accuracy of clinical diagnosis is less reliable. For a confirmed diagnosis, electrodiagnostic findings require fulfilment of at least 2 demyelinating features in two different motor nerves with sensory conduction abnormalities in at least 2 nerves in the affected limb. This is difficult to achieve as all the motor nerves in the affected limb are required to meet demyelination criteria. In addition, individual nerves in the affected limbs, especially the lower limbs come with specific misdiagnosis pitfalls, making misinterpretation of demyelinating features difficult. The role of demyelination of sensory nerves is limited in improving diagnosis but additional supportive criteria improved diagnostic certainty.
Conclusion
The updated EAN/PNS diagnostic criteria for focal CIDP has its own limitations on both clinical and electrodiagnostic grounds. The inclusion of supportive criteria improves diagnostic certainty, but the reliability and accuracy require future study.
Postoperative brainstem cavernous hemangioma complicated with LGI1 encephalitis and hypertrophic olivary degeneration: A case report and literature review
Authors: Zhu Ling , Han Yongsheng , Zhang Liangjie , Xu Yin , Wang Xun , Jin Huizhu
Published: October 2023

Background: This article reports the case of a patient with postoperative brainstem cavernous hemangioma complicated with anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis and hypertrophic olivary degeneration (HOD) to raise awareness of clinicians regarding LGI1 encephalitis and HOD.
Case presentation: We retrospectively analyzed the case data of a young male admitted to our hospital in 2022, with complaints of recurrent dizziness and headache. Based on the findings of craniocerebral computed tomography, the patient was diagnosed to have brainstem cavernous hemangioma, and he underwent surgical resection of the tumor. He subsequently developed unexplained abnormal mental behavior 1 month after the surgery. Laboratory examination revealed a positive result for anti-LGI1 antibodies in the serum and cerebrospinal fluid. Electroencephalography showed slow wave alterations in the right occipital lobe and the mesial and posterior temporal lobes. These findings confirmed the diagnosis of LGI1 encephalitis. The patient underwent immunotherapy and symptomatic treatment, and his health significantly improved. Six months later, cranial MRI showed HOD.
Conclusions: The complication of brainstem cavernous hemangioma with LGI1 encephalitis and HOD after surgical resection is an extremely rare case, and a complex mechanism underlies the occurrence of this complication. Hence, clinicians must focus on early detection and treatment of this complication to achieve a better patient prognosis.
Implementing the organizational readiness for change (ORIC) survey during a novel midwifery preceptor program in Sierra Leone: Stakeholder results
Authors: de Water Brittney van , Longacre Ashley , Hotchkiss Jenny , Sonnie Mustapha , Mann Julie , Lemor Elizabeth
Published: October 2023

Background
Sierra Leone has one of the world’s highest maternal and infant mortality rates and suffers from a shortage of well-trained health professionals, including midwives. Prior to engaging in systematic interventions, it is critical to measure organizational readiness to gauge members’ psychological and behavioral preparedness to implement change. We aimed to measure the organizational readiness for implementing change of healthcare workers and administrative leaders at two schools of midwifery in Sierra Leone prior to the rollout of a midwifery preceptor program.
Methods
The Organizational Readiness for Implementing Change (ORIC) survey is a validated 12-item questionnaire designed to assess two domains of organizational readiness for change: change commitment (motivation) and change efficacy (capacity). All survey items begin with the same prompt and a five-item Likert scale response, with seven questions about change commitment and five about change efficacy. Data collection occurred in two schools in Sierra Leone during two day-long meetings with stakeholders. Statistical analysis was conducted using descriptive statistics and Wilcoxon rank-sum test to compare independent samples: School 1 versus School 2 (site), midwife versus other roles (role).
Results
Participants included 42 respondents (mean age 41 years, 95% female). Surveys were distributed evenly between the two sites. Occupations included midwifery faculty (n = 8), administrators (n = 5), clinicians (n = 25), and clinical educators (n = 4). Domain 1 (change commitment) had a mean score of 4.72 (SD 0.47) while Domain 2 (change efficacy) had a mean score of 4.53 (SD 0.54) out of a total potential score of five. There were no statistically significant differences between site responses for Domain 1 (p = 0.5479) and Domain 2 (p = 0.1026) nor role responses for Domain 1 (p = 0.0627) and Domain 2 (p = 0.2520).
Conclusion
Stakeholders had very high overall readiness for change across all ORIC questions for both change commitment and change efficacy. Mean scores for change commitment were slightly higher which is not surprising given the low-resourced settings stakeholders work in while training students. High mean scores across sites and roles is encouraging as this novel preceptor program is currently being rolled out.
Thermal explosion problem with a stochastic boundary: quasi-stationary approximation and direct numerical modelling
Authors: Donskoy Igor
Published: October 2023

This paper investigates a stochastic modification of the Frank-Kamenetsky problem of exothermic reaction development in a flat layer with random temperature fluctuations at the outer boundary. Ignition conditions are estimated in a quasi-stationary approximation. The equation of unsteady heat transfer in a reacting medium is solved numerically for a large number of random realizations. The results of a comparison of the two approaches show that the nonstationary development of a thermal explosion in a stochastic environment can be approximated by quasi-stationary estimates with correction of the critical temperature. The distribution of ignition characteristics (ignition temperature, maximum ambient temperature, ignition time) is discussed and their dependence on the input parameters is studied.
Effect of micro-friction stir welding parameters on the mechanical properties and microstructure of 5052 aluminum thin sheets
Authors: Hwang Yeong-Maw , Lu Cheng-Yu , Chen Ren-Yu
Published: October 2023

This study examined micro-friction stir welds in aluminum alloys 5052-0 and 5052-H32, using 0.8 mm thick sheets. The analysis aimed to evaluate weld heterogeneity across various process parameters through microstructural examination and tensile testing. The findings suggested that elevated rotational speeds cause more heat input, resulting in adequate energy for grain growth within the stirred zone. A substantial number of equiaxed crystals that were less than 5 μm in size were observed in the stirred zone. Moreover, the number of these crystals increased with an increase in the rotational speed. The interaction of high strain rate and heat input promotes grain growth, but its effect is limited by grain size and agitator pin speed. The yield strength joining efficiencies of 5052-O and 5052-H32 range from 136% to 156% and 103% to 112%, respectively. Similarly, the tensile strength joining efficiencies range from 75% to 82% and 92% to 100%, respectively. The micro friction stir welding parameter was found to provide superior properties compared to conventional thick plate friction stir welding.
Intestinal metabolomics in premature infants with late-onset sepsis
Authors: Liu Jingfei , Zhang Li , Li Dong , Yu Xiaotong , Gao Ying , Zhou Ying
Published: October 2023

We aimed to investigate the characteristics of intestinal metabolomics and non-invasive biomarkers for early diagnosis of late-onset sepsis (LOS) by analyzing gut metabolites in preterm infants with LOS. We collected stool samples from septic and healthy preterm infants for analysis by liquid chromatography-mass spectrometry (LC-MS). 123 different metabolites were identified and 13 pathways were mainly involved. Glycine, serine, and threonine metabolism; glyoxylate and dicarboxylic acid metabolism; glutathione metabolism; primary bile acid biosynthesis; steroid synthesis; pentose and glucuronic acid interconversion may be involved in the pathogenesis of LOS in preterm infants. The significant expression of N-Methyldopamine, cellulose, glycine, gamma-Glutamyltryptophan, N-Ribosylnicotinamide and 1alpha, 25-dihydroxycholecalciferol showed specific diagnostic values and as non-invasive biomarkers for LOS.
Comparison of the Antibacterial Properties of Resin Cements with and without the addition of Nanoparticles: A Systematic review and Meta-analysis
Authors: Saini Ravinder , Vaddamanu Sunil Kumar , Kanji Masroor Ahmed , Quadri Syed Altafuddin , Hassan Saeed Awod Bin , Anil Sukumaran , Shrivastava Deepti , Srivast Kumar Chandan
Published: October 2023

Resin cement exhibits numerous therapeutic advantages in comparison to conventional luting materials. However, the effectiveness of its antibacterial properties remains uncertain. Nanotechnology provides a viable option, whereby the integration of nanoparticles (NPs) can potentially augment the antibacterial effectiveness of resin cement. The objective of this study is to conduct a comprehensive literature review and do a meta-analysis in order to assess the antibacterial effectiveness of incorporating nanoparticles into resin cement. A comprehensive search of the PubMed and Scopus databases up to September 12, 2023 was conducted in order to identify relevant scholarly articles that have examined and evaluated the antibacterial effectiveness of resin cement with and without the incorporation of nanoparticles (NPs). The systematic review and meta-analyses adhered to the PRISMA guidelines for reporting. The study was conducted using Review Manager (RevMan) version 5.4, and the results were evaluated and provided in terms of standardized mean difference (SMD) along with a matching 95% confidence interval. (CI). The search retrieved seven eligible studies. The analysis found that resin cement with NPs significantly reduced the colony forming unit (CFU) counts compared to resin cement without NPs (SMD = -4.91, 95% CI (-7.03, -2.78), P < 0.00001). Furthermore, resin cement, in addition to NPs, significantly reduced bacterial metabolic activity compared to the control group (SMD = -7.05, 95% CI (-10.43, -3.66), P < 0.0001). The use of nanoparticles (NPs) in resin cement has been shown to enhance its antibacterial properties, possibly mitigating the occurrence of secondary caries. Future clinical trials are required to validate the beneficial effects of NPs in conjunction with resin cement in the prevention of secondary caries.
Quantifying Green Hydrogen Cost Reduction from Policy-Induced Industrial Demand-pull and Offshore Wind Integration
Authors: McLaughlin Sandy , Oluleye Gbemi
Published: October 2023

Green hydrogen produced via curtailed offshore wind (OSW)-powered electrolysis offers a solution to bridge the gap between a rapidly expanding renewable energy capacity and the hard-to-abate industrial sector as a net zero emission fuel and feedstock. However, the cost of green hydrogen remains too elevated to compete with blue and grey hydrogen. A novel multi-layer methodology (consisting of an energy flow balance between green hydrogen supply and demand, and a temporal market penetration assessment model) is developed to assess whether the use of curtailed OSW and exploitation of industrial demand – incentivised by market-based policy – are sufficient to narrow the cost disparity between green hydrogen and its alternatives from 2025 through 2050. The method devises a policy mix (consisting of grants, emissions trading, and subsidy) for triggering a maximum and realistic green hydrogen cost reduction. The model was applied to a UK case study and findings show that (1) even when the supply of green hydrogen from curtailed OSW is insufficient to meet industrial demand, requiring complementary dedicated resources, a cost reduction of 6.76–18.76% is still possible, and (2) an optimal policy mix of the Emissions Trading Scheme and Subsidy – Low Carbon Hydrogen Production Business Model can establish cost competitiveness from 2025 onwards, exemplifying the commensurate relationship between demand-pull and cost reduction due to learning by doing and economies of scale. Ultimately results show that with effective policy support industrial demand can be exploited to reduce the cost of green hydrogen.
Benefits of an Optimal Policy-Induced Diffusion Pathway for Green Hydrogen Uptake in Refineries Globally
Authors: Rtabi Abla , Oluleye Gbemi
Published: October 2023

Decarbonising the oil refining industry is becoming increasingly urgent in realising a sustainable future as this sector is responsible for 4% of global greenhouse gas emissions. Replacing grey hydrogen used as feedstock for hydrotreating and hydrocracking, by green hydrogen, could significantly reduce these emissions. The absence of market uptake for green hydrogen is associated with its low cost-competitiveness. There is also a lack of appropriate supporting policy instruments. This work develops a novel temporal market penetration optimisation model, which aims to synthesise a cost-effective policy-induced diffusion pathway to reach 100% green hydrogen uptake in 512 refineries globally by 2050. The model determines the optimal mix of market-based policies required to reduce cost and generate demand for green hydrogen in refineries leading to further cost reductions. The model is applied to show how to further reduce total mitigation cost for government and industry by exploring diffusion pathways: an optimisation-led pathway (scenario 1) and S-shaped diffusion curve based on Rogers’ innovation diffusion theory (scenario 2). Results indicate 100% uptake can happen cost-effectively in a shorter time and 16% reduction in mitigation cost is possible with the optimisation-led pathway. A mix of carbon tax (from 27.98 $/tCO2 to 102.50 $/tCO2), contracts for difference (subsidy intensity from 300 $/tCO2 to 307.5 $/tCO2) and renewable electricity tax credit (from 0.04 $/kWh to 0.043 $/kWh) are required to replace grey with green hydrogen. Asia and North America are early adopters while the other regions are spread between early majority, late majority, and laggards.
Recent Development on the Extraction Process of Plants Essential Oil and its Effect on Chemical Composition: A Review
Authors: Joco Randy A , Lavarias Jeffrey A , Peneyra Ruel G , Somera Carolyn Grace
Published: October 2023

This study presents a thorough review on different innovative extraction techniques of different plant essential oil derived from its peel, leaves, seeds and shrubs. The review also entails the different pre-treatment processes that affects the quality and recovery of the plant essential oil. Also, discussed the recently developed green extraction method such as Microwave Assisted Hydrodistillation (MAHD), Solvent Free Microwave Extraction (SFME), Ultrasound Assisted Extraction (UAE), Supercritical Fluid Extraction (SFE) and Ohmic Heated Assisted Hydrodistillation (OHAD). The impact of these extraction process on the important chemical composition of essential oil is further analyzed in this review. The important parameters in extraction is also studied such as the water to material ratio, extraction temperature, power input and extraction time. Based on the different articles reviewed, it signifies that the innovative extraction method improves the quality and quantity of the essential oil yield. It also improved the number of component that can be extracted in the plant essential oil and its biological activities such as antioxidant and antimicrobial activities. Thus this review aims to emphasize the potential of the newly developed essential oil extraction techniques that would help to boon the pharmaceuticals, food and agriculture industry.
SEX RATIO, SIZE AND WEIGHT STRUCTURE, LENGTH-WEIGHT RELATIONSHIP AND CONDITION FACTOROF THREE DEMERSAL FISH SPECIESOF SENEGALESE WATERS, WEST AFRICA
Authors:   Faculte des Sciences et Techniques (FST), Laboratoire de Biologie Evolutive, decologie et de Gestion des Ecosystemes, Universite Cheikh Anta Diop de Dakar (UCAD), Senegal, BP 5005 Dakar-Fann., Dione Ayatoulaye , Ba Abdoulaye ,   Institut Fondamental dAfrique Noire-Cheikh Anta Diop (IFAN-CAD), Laboratoire de Biologie Marine, Senegal, BP 206 Dakar-Fann., Bonaventure Badji Luc ,   Institut Fondamental dAfrique Noire-Cheikh Anta Diop (IFAN-CAD), Laboratoire de Biologie Marine, Senegal, BP 206 Dakar-Fann.,   Institut Universitaire de PÃƒÂªche et dAquaculture (IUPA), Faculte des Sciences et Techniques (FST), Universite Cheikh Anta Diop de Dakar (UCAD), Senegal, BP 5005 Dakar-Fann., Tidiane Ba Cheikh ,   Faculte des Sciences et Techniques (FST), Laboratoire de Biologie Evolutive, decologie et de Gestion des Ecosystemes, Universite Cheikh Anta Diop de Dakar (UCAD), Senegal, BP 5005 Dakar-Fann.
Published: October 2023

This study examined size and weight structure, length-weight relationship (LWR) and condition factor (K) for three demersal species caught by small-scale fisheries: Cephalopholistaeniops, Boopsboops and Plectorhinchusmediterraneuson the Senegalese coast from September 2013 to August 2014.Driftnets were the most commonly used fishing gear to catch fishes, followed by longlines nÃ‚Â° 7 to 12 and gillnets (35-40 mm mesh).Females outnumbered malesin all seasonsin the landingssites and Length-frequency distributions varied significantly between sexes for all seasons (P<0.05). The value of exponent b of length-weight relationship of combined sexesforB.boops, C.taeniopsand P.mediterraneus, were found to be respectively 2.8332, 3.0938 and 2.8511. Slopes of females and males LWRsdid not differ statistically within the same season, while they differed between the warm and the cold season. Analysed data showed that the condition factor (K) of B. boobswas less than 1, indicating that this species was not in good physiological stateKscore of 0.95Ã‚Â±0.13), while for C. taeniopsand P.mediterraneus(K score respectively of 1.46Ã‚Â±0.20 and 1.30Ã‚Â±0.15) the values weregreater than 1,implied that this demersal fish was in good physiologicalcondition.The data collected provided new information on the morphological and physiological characteristics of these species populations.
Green perceived value and green product purchase intention of Gen Z consumers: Moderating role of environmental concern
Authors: Hudayah Syarifah , Aulia Ramadhani Melda , Arum Sary Kezia , Raharjo Sugeng , Yudaruddin Rizky
Published: October 2023

The primary objective of this study is to examine the connection between Generation Z Indonesian consumers’ perceptions of value for green products and their purchase intentions, with a supplementary investigation into how environmental concerns moderate the influence of perceived green value on their intention to purchase green products. Between June and December 2021, a probability sampling technique, specifically stratified random sampling, was used to select a sample of 543 Indonesian Generation Z consumers. The data were analyzed using a variance-based method, namely partial least squares, within the context of structural equation modeling. The analysis reveals that functional value, conditional value, and environmental concern significantly and positively affect the intention to purchase green products. This indicates that Generation Z consumers are more inclined to choose green products when they perceive them to have good functional value, when specific conditions or requirements support the purchase, and when they have a high environmental concern. Moreover, environmental concern moderates the effect of social value on the intention to purchase green products. This suggests that more environmentally conscious consumers are more likely to be influenced by social value benefits when deciding to buy green products, highlighting the complex interplay between environmental and social motivations in shaping consumer behavior towards sustainability.
The Impact of Macroeconomic Variables on the Contingent Built-in Inflation: Evidence from Indonesia
Authors: Sharma Prabhanshu , Yadgari Mohammad Rashed
Published: October 2023

This paper examines the relationship between Exchange rates, GDP, and Government expenditure as macroeconomic variables on the Inflation of Indonesia which is quite struggling with increased prices of goods and services as it has been a  persistent problem in Indonesia for many years. In 2023, it is so far 5.47% which is above the target set by the central bank of Indonesia of 2-4%. With the data taken from World Bank and IMF, the methodology consists of stationarity check, Cointegration analysis, and Error Correction Model to identify the long-run nexus among variables. The estimation result found that GDP is positively correlated with Inflation, Exchange rate is positively correlated with mild effects on inflation and government expenditure is negatively correlated with Inflation.
Minimizing Defects in Radiator Grille Upper Garnish Parts using Six Sigma (DMAIC) at PT. AAS
Authors: Mariana Yosica , Andrean Wandi , Lestari Nina Tania
Published: October 2023

To achieve quality improvement, companies must align their production processes with customer needs, control production costs effectively, and maintain product quality. This approach enhances customer satisfaction, increases market share, and boosts profitability. PT. AAS, an automotive company specializing in injection molding and painting, relies on resin as its primary raw material to produce car parts for major clients like Hyundai, Suzuki, and Astra. To dominate the market, PT. AAS must prioritize delivering quality products on time to earn customer trust and secure continuous orders. Initially, the QC data for the injection molding area showed a high defect rate of approximately 17.5% for the Garnish Radiator Grille Upper part, from December 2022 to May 2023. Prior to implementing the Six Sigma method, PT. AAS had a DPMO (Defects Per Million Opportunities) value of 58,177, equivalent to a 3.10 Sigma level. After applying the Six Sigma DMAIC (Define, Measure, Analyze, Improve, Control) process, the DPMO decreased to 17,991, resulting in a 3.60 Sigma level. This suggests that PT. AAS currently operates at a 4 Sigma level, with a strong potential to reach 5 or even 6 Sigma by addressing the root causes of rejection. The fishbone analysis highlights the need for action across all departments, including Management. Key areas to focus on include Material, ensuring the correct resin delivery to the Injection Molding station; Machine, verifying proper machine settings and utilizing the 5S methodology; Environment, optimizing room temperature and ventilation; and Man, providing training to enhance operators' knowledge and sense of responsibility.
Analysis and Design of Asset and Non-Asset Lending Information Systems in the Informatics Engineering Service Unit at Astra Polytechnic
Authors: Andrean Haikal , Devi Indah Cyithia , Nur’aini Fadhilah , Wizard Michael Edigia
Published: October 2023

The development of information technology is developing rapidly and has a positive impact on organizational, one of which is Astra Polytechnic, especially at UPT Informatics, which supports the operational activities of inventory lending in the form of assets and non-assets which are considered inefficient. The process of recording, submitting, and approving inventory loans is still done manually, so it takes a lot of time and is prone to errors. The process of recording inventory data is still using excel, loan applications are still made using hardcopy forms and there are no asset and non-asset reports. The aim of research is to analyze needs and design of a system for lending assets and non-assets at UPT Informatics based on Web Applications in order to overcome these problems. The design uses System Development Life Cycle (SDLC) based on Prototyping methodology until design stage. The process of analysis and design is explained using Unified Modeling Language (UML) approach. Analysis of system requirements is carried out on ongoing business processes, which are then outlined in design of asset and non-asset lending information systems, especially in documentation process to produce reports according to company needs.
Possibilities of local therapy of recurrent candidiasis against the background of mixed vaginal dysbiosis
Authors: Borovikov I. O. , Kutsenko I. I. , Borovikova O. I. , Andreeva A. A. , Filippova L. A. , Avakimyan V. A. , Nikogda Ju. V.
Published: October 2023

Introduction. The article describes the experience of treating patients with recurrent vulvovaginal candidosis combined with mixed vaginal dysbiosis using a variant of complex local therapy with drugs containing sertaconazole nitrate and benzyl-dimethyl-[3-(myristoylamino) propyl] ammonium chloride monohydrate.

Aim. To evaluate the efficacy of local therapy in patients with recurrent vulvovaginal candidosis with underlying mixed non-specific vaginal dysbiosis.

Materials and methods. A prospective open randomized clinical trial to evaluate the outcomes of treatment with drugs containing sertaconazole nitrate at a dose of 300 mg (Flucovag®, vaginal suppositories, two times with an interval of 7 days) and benzyl-dimethyl-[3-(myristoylamino)propyl] ammonium chloride monohydrate at a dose of 15 mg (Miramistin® vaginal suppositories once a day at bedtime for 10 days) in women with mixed nonspecific infectious vaginal diseases with underlying recurrent vulvovaginal candidosis (n = 68) was conducted. Methods: vaginal microbiota evaluation with AmpliPrime® Florocenosis/Bacterial vaginosis-FL PCR (NextBio LLC, Russian Federation), vaginal pH, Hay/Ison scoring criteria, antimycotic sensitivity evaluation against Candida spp. (NCCLS standards).

Results and discussion. This kind of local complex therapy in patients with recurrent vulvovaginal candidosis combined with mixed vaginal dysbiosis using drugs containing sertaconazole nitrate (Flucovag®) and benzyl-dimethyl[3-(myristoylamino) propyl]ammonium chloride monohydrate (Miramistin®), followed by probiotic contamination showed high clinical (94.1 ± 2.3%) and microbiological (81.9 ± 2.1%) efficacy combined with safety and satisfactory compliance.

Conclusion. A comprehensive approach to the treatment of mixed nonspecific vaginal dysbiosis with underlying recurrent vulvovaginal candidosis showed high clinical efficacy and satisfactory compliance.
Vital issue of intimate care for women
Authors: Dvoriankova E. V. , Sakaniya L. R. , Kantin O. M. , Korsunskaya I. M.
Published: October 2023

The vulva and vagina are a unique anatomical region, which anatomy and physiology changes throughout a woman's life. The most noticeable changes are hormone-mediated and are associated with the onset of puberty, menstrual cycle, pregnancy and menopause. The microbiome changes over time due to various factors, such as hormones, which leads to a change in pH. Various hygiene practices and habits also have a huge impact on the microflora of the vulva and vagina, and therefore on a woman’s health. Today, the market offers a huge number of care and hygiene products designed for the genital area of women. But, unfortunately, information about their correct use and safety of use is limited. For example, various health behaviours, such as vaginal douching and pubic hair removal are still widely used, although there is some evidence of their negative impacts on the health of the vulva and vagina. Despite the abundance of specialized intimate hygiene products, the use of general care products that are not intended for the genital area and therefore can cause irritation, itching and other unpleasant effects is reported. Foreign guidelines for intimate female hygiene practices resolve itself to recommendations of daily vulva cleansing with a gentle hypoallergenic liquid wash. There is a need to increase women's awareness about rational choice of feminine hygiene products and disorders of the vulva and vagina to improve their intimate health.
Açık Kültür: Dijital Kültürel Miras ve Kültürel Mirasa Açık Erişim
Authors: Alav Orhan
Published: October 2023

Tarihsel süreçte tekstil ve hazır giyim sektörü, sanat, tasarım, mühendislik, malzeme bilimi gibi farklı disiplinlerdeki gelişimlerin görünür olmasında aracı olmuştur. Moda, tekstil ve giyim, farklı, alışılmışın dışında olan malzemeler ile tekniklerin kullanımına en uygun alanların başında gelirken, yenilikçi gelişmelerin sonunda farklı alanlara hizmet etmeye başlamıştır. Bu araştırmada, tekstilde iplik tasarımının estetik ve işlevsel unsurlar sentezinde, moda ve tekstil tasarımına etkisi sorgulanmış, çağımızın gereksinimi yenilikçi ürün geliştirme çalışmalarında, öncelikli tasarımcı rolünün önemi ve bütünsel olarak konumlandırılma gerekliliği ele alınmıştır.
Çalışma içerisinde, iplik tasarımının yeniyi ortaya çıkarmada ki kavramsal önemi amaçlanarak inovasyon ele alınmıştır. Koleksiyon ve ürün tasarım süreci içerisinde, tasarım nesnesi ipliğin mevcut potansiyeli, kazanımları, dikkate alınarak katkı sağlamaya ilişkin tasarım örneklerine yer verilmiştir. Yenilik yaratımında, belirleyici unsur olarak görülebileceği ifade edilmiş, çalışmanın amacına yönelik tekstil ve moda ürün tasarımı görselleri ile literatür araştırmaları, günümüzün tasarım anlayışı ile tasarımcılara katkı sağlayacak, nitelikli, yenilikçi, tasarım çalışmaların ortaya konması amaçlanarak değerlendirilmiştir.
Children’s drawings of 1917–1918 in Moscow: From iconography to sociology
Authors:   St. Petersburg State University, Orekh Ekaterina A. , Boitsova Olga Yu. ,   Peter the Great Museum of Anthropology and Ethnography (the Kunstkamera) of the Russian Academy of Sciences
Published: October 2023

The paper demonstrates the possibilities of sociological research on the basis of children’s drawings. The authors analyze drawings made by schoolboys in Moscow during the revolution and the beginning of the Civil War in 1917–1918 in Russia. Using iconography as a research method, the authors examines how political characters are depicted in children’s drawings. The objective is to explore the content of the drawings to establish whether the process of political socialization of younger schoolchildren has begun, and whether the sources of visual propaganda of the time influenced the formation of the political consciousness of children. The presence of the four iconographic attributes of the Bolsheviks in children’s drawings indicates that children distinguished them from other political characters. The authors find that some children formed their own attitude as early as 7 to 11 years of age. In a number of drawings children expressed their opinion to the Bolsheviks, equipping the characters with a complex of traits signifying low cultural level, negatively marked poverty, aggression and unhealthy habits. The study therefore concludes that political socialization in Russia in 1917–1918 began under the significant influence of visual propaganda. The analysis of the drawings by school children suggest that the caricatures published in satirical journals and postcards were capable of exerting a direct influence on the children’s political impressions.
Kinetic Art: The Leningrad Experience, the 1920s–1990s
Authors:   St. Petersburg State University, Mamonova Irina G.
Published: October 2023

Kinetic works of Leningrad artists have never been studied as a separate topic. In 1965–1967, kinetic art broke into the Leningrad art scene with bright projects of a Moscow artist collective called “Dvizhenie” (“the Movement”). Soon, several young Leningrad artists became active members of the collective. At the beginning of the 1970s, the impulse given by the “Dvizhenie” led to the formation of an independent Leningrad art collective which worked on color music kinetic art performances but broke up short afterwards. Is it possible to talk about some kind of a separate Leningrad branch of kineticism? Leningrad artists whose works in the 1960s, the 1970s and later periods were related to the kinetic art perspective, and even explicitly aligned with it, did not identify themselves with kineticism. Even in the 2010s, no one talked about kineticism in connection with some exhibitions in Saint Petersburg which presented completely kinetic works of art. Today, in the wake of the growing interest in this movement in Russia in the context of recent exhibitions, the concept of kineticism has expanded to include new names. The article considers activities of Leningrad artists associated with this art movement in the field of theatrical kinetic performances (the “Dynamic” collective), three-dimensional counter-relief objects (L. Borisov), color light music and paintings visualizing music (V. Afanasyev), and architectural design / color light music projects (A. Lanin). The study also traces parallels between proto-kinetic works of Leningrad avant-garde of the 1910s–1920s, and works of Leningrad kinetic artists of the 1960s–1970s.