bluuebunny/crossref_metadata_2025 huggingface dataset:
Peranan Guru Sekolah Minggu dalam Membangun Budaya Membaca dan Menulis
Authors: Tulle Ferry Yefferson
Published: July 2023

Reading and writing is the first commandment that was revealed by God to humans, It is an encouragement to mankind to read meaningful books and books of life about successful characters both in the Bible and who are currently the owners of Science (written on natural events) through reading here's gonna be know. Living in an oral culture from year to year, unable to manage a reading and writing culture. It should be realized that making a personal library at home. Has the house held many books of knowledge for children? Children who are students and students, because books are knowledge that must be added to in order to get clear water of knowledge. The tradition of reading which has now been widely practiced in the world of formal education should also be cultivated wherever and whenever. Make books a good friend, at church at school or wherever we are. every month the money is set aside to buy books to save for children, so that children do not bother when children study at school, smart children answer questions from teachers at school can excel through reading, reading and writing. AbstrakMembaca dan menulis adalah perintah pertama yang diwahyukan Tuhan kepada manusia, Merupakan anjuran kepada umat manusia untuk membaca buku – buku bermakna dan buku kehidupan tentang tokoh yang telah sukses baik dalam Alkitab maupun yang pada saat ini sang pemilik Ilmu-tertulis pada kejadian alam) lewat membaca inilah akan menjadi tahu. Hidup dalam budaya lisan dari tahun ke tahun, tidak mampu mengelola budaya membaca dan menulis. Perlu disadari bahwa membuat perpustakaan pribadi dirumah.  Sudahkah rumah itu menyimpang banyak buku pengetahuan bagi anak – anak? Anak yang berstatus pelajar dan mahasiswa, sebab buku adalah ilmu yang harus terus ditimbah agar mendapatkan air jernih pengetahuan. Tradisi membaca yang kini telah banyak dilakukan di dunia pendidikan formal kiranya membaca buku juga harus dibudayakan dimanapun dan kapan. Jadikan buku sebagai teman yang baik, di gereja di sekolah atau dimana kita berada. setiap bulan dapat uang itu disisikan untuk beli buku menyimpan buat anak – anak, supaya anak – anak tidak repot saat anak – anak belajar di sekolah, anak – anak pintar menjawab pertanyaan dari guru di sekolah dapat berprestasi lewat baca membaca dan tulis menulis.
Konsep Penebusan dalam Kitab Rut
Authors: Wassar Sarah
Published: July 2023

Every believer who wants to experience God in daily life in making important and less important decisions, both consciously and unconsciously. The message that was conveyed was that a man by grace made the decision to redeem and renew a lost inheritance, and pure love removed all difficulties. The method used to explain the meaning of redemption in the book of Ruth is a literature study in the form of a literature study. Through the description of the literature review, the author finds the results of several biblical reviews of the concept of redemption in the book of Ruth. AbstrakSetiap orang percaya yang ingin berpengalaman dengan Tuhan dalam kehidupan sehari-hari dalam membuat keputusan penting maupun kurang penting, baik sadar maupun tidak sadar. Berita yang disampaikan yaitu seorang laki-laki dengan kasih karunia membuat keputusan untuk menebus dan memperbaharui warisan yang hilang, serta kasih yang murni menghilangkan segala kesulitan. Metode yang dipakai untuk menjelaskan makna penebusan dalam kitab Rut yaitu studi literatur yang berupa kajian Pustaka. Melalui deskripsi kajian pustaka, maka Penulis menemukan hasil beberapa tinjauan yang alkitabiah tentang konsep penebusan dalam kitab Rut.
Kebudayaan bagi Pekabaran Injil
Authors: Yulianus Juanda
Published: July 2023

Culture in each region has its own characteristics. But these characteristics do not limit the evangelism is carried out through and within culture. Culture as access in evangelism. The relationship between culture and evangelism is that the evangelist understands the culture and thoughts or beliefs of the local community, then finds the right method to carry out the evangelism. The discussion of this research uses a qualitative method, namely the study of literature. Understanding culture for evangelism is summarized and is a literature study by reading books related to culture for evangelism so that it becomes a new and useful discovery. AbstrakKebudayaan di setiap daerah mempunyai ciri khas tersendiri. Namun ciri khas tersebut tidak membatasi pekabaran Injil dilakukan melalui dan di dalam kebudayaan. Kebudayaan sebagai akses dalam pekabaran Injil. Hubungan antara kebudayaan dengan pekabaran Injil yaitu pemberita Injil memahami kebudayaan dan pemikiran atau kepercayaan masyarakat setempat, kemudian menemukan metode yang tepat untuk melakukan pekabaran Injil. Pembahasan tentang penelitian ini menggunakan metode kualitatif yaitu studi literatur. Memahami kebudayaan bagi pekabaran Injil ini dirangkumkan dan merupakan suatu kajian pustakam dengan cara membaca buku-buku yang berkaitan kebudayaan bagi pekabaran Injil sehingga menjadi suatu penemuan yang baru dan bermanfaat.
Membangun Budaya Literasi Mahasiswa Pascapandemi melalui Optimalisasi Perpustakaan: Studi Kasus pada Perpustakaan STT Intheos Surakarta
Authors: Sari Pebrina Dwi , Rifai Rifai , Lande Ayub E
Published: July 2023

The Covid 19 pandemic, entering its third year, has brought many changes in all fields, including activities in the campus library. Libraries can no longer fully carry out complete face-to-face services, but various restrictions have been placed on reducing mobility and suppressing the transmission of the COVID-19 virus. Therefore, it is urgent for the recovery of the library after the pandemic, namely by optimizing the campus library so that library services can be felt again by the campus students. In addition, to re-earth the literacy culture and student interest in reading which has decreased due to the pandemic. Because one of the benchmarks for competent students in the 21st century is students who think critically, have global insight, and have high character and spiritualism. This study uses a descriptive qualitative research method with a case study approach that is focused on students of STT Intheos Surakarta and the efforts made by the campus library to optimize the library, including launching a campus literacy movement, socializing the program, creating a lecture reading corner, increasing the competence of librarians in digital libraries, digitizing theology books, maximizing social media as a means of promoting new book catalogs and improving modern library supporting infrastructure.  AbstrakMasa pandemi Covid 19 memasuki tahun ketiga ini telah membawa banyak perubahan dalam segala bidang, tidak terkecuali aktivitas di perpustakaan kampus. Perpustakaaan tidak bisa lagi sepenuhnya melakukan layanan tatap muka penuh tetapi dilakukan berbagai pembatasan guna mengurangi mobilitas dan menekan penularan virus Covid-19. Oleh sebab itu menjadi suatu urgensi guna pemulihan perpustakaan pasca pandemi yaitu dengan optimalisasi perpustakaan kampus sehingga layanan perpustakaan dapat kembali dirasakan oleh mahasiwa kampus tersebut. Selain itu mem-bumikan kembali budaya literasi dan minat baca mahasiswa yang menurun akibat pandemi. Karena salah satu tolok ukur mahasiswa yang kompeten di abad 21 adalah mahasiswa yang berfikir kritis, berwawasan global dan memiliki karakter serta spiritualisme yang tinggi. Penelitian ini meng-gunakan metode penelitian kualitatif deskriptif dengan pendekatan studi kasus yaitu difokuskan pada mahasiswa STT Intheos Surakarta dan upaya yang dilakukanperpustakaan kampus untuk optima-lisasi perpustakaan yaitu diantaranya: mencanangkan gerakan literasi kampus, mensosialisasikan program tersebut, membuat pojok baca kuliah, peningkatan kompetensi pustakawan dalam perpusta-kaan digital, digitalisasi buku – buku Teologi, memaksimalkan media sosial sebagai sarana promosi katalog buku baru dan peningkatan sarana prasarana penunjang perpustakaan masa kini.
Experiencia de capacitación docente en la creación de recursos digitales en H5P: caja de herramientas para la interactividad
Authors: Vallejo Alcira , González Alejandro
Published: July 2023

El presente trabajo aborda el marco conceptual de la interactividad de los materiales en educación a distancia y describe una experiencia de capacitación docente destinada a profesores de cursos de nivel secundario. La capacitación presenta a los docentes un abanico diverso de herramientas que pueden incorporarse al aula virtual para promover la interactividad en la mediación tecnológica entre el estudiante y los diferentes elementos de la propuesta educativa. Se propuso a los participantes el abordaje pedagógico de la interactividad a través de herramientas de uso libre nucleadas bajo la denominación H5P, recientemente incorporadas como complemento nativo en las últimas versiones del entorno Moodle, con el objeto de enriquecer las propuestas educativas en un contexto de virtualización masiva como consecuencia de la pandemia COVID-19. Se detalla la estrategia didáctica y los resultados obtenidos.
Implementasi dan Manfaat ICE-Breaking pada Proses Pembelajaran di SMP Negeri 11 Pekanbaru
Authors: Setiawan Sinaga Joel , Suryati  , Syaflita Dina
Published: July 2023

In the learning process, the teacher's ability to direct students' attention and motivation to learn is tested, especially at the elementary school level, where students do not yet know how to improve themselves, at this level they often do not focus on receiving learning, so students no longer receive attention and motivation. Teachers must understand the psychological state of students in order to create a good, fun and effective learning atmosphere. So that the learning objectives or achievements of the day are realized. One way that can be done to attract students' attention is to apply ice-breakers in learning activities that are used to be able to arouse enthusiasm and also to attract students' attention. the results of the study it can be concluded that the application of the ice breaking strategy can overcome student boredom in the science learning process at SMP Negeri 11 Pekanbaru.
Yordan Yovkov ve “Telgraf Telleri Boyunca” Öyküsü Üzerine Bir İnceleme
Authors: HACI Sadık
Published: July 2023

Yordan Yovkov Bulgar edebiyatının en önemli yazarları arasında yer almaktadır. İnsancıl yapısı ve ilgi uyandırıcı öyküleriyle sevilen ve çok okunan yazarlar arasındadır. Sadece Bulgaristan’da değil kitapları ve eserleri farklı dillere çevrilerek dünya edebiyatına katkı sağlamıştır. Türklere bakış açısı ve insancıl tasvirleriyle Türk okuyucusu tarafından da bilinmektedir. Türkiye’de en çok kitabı çevrilen Bulgar yazar olarak ikinci sırada yer almaktadır. 1927 yılında yayımladığı “Telgraf Telleri Boyunca” adlı öyküsü ise ilk günden günümüze kadar okuyucuları etkilemeye devam etmekte ve Bulgar milli eğitimin müfredatında yer almaktadır. Bu sebeple öykü birçok edebiyatçı ve eleştirmenin dikkatini çekmekte ve halk arasında popüler olmaya devam etmektedir. Öyküde işlenen umut kavramı ve beyaz kırlangıç sembolü talihsiz ailenin kızı için aradığı iyileştirme umudunu ifade etmektedir. Bu çalışmanın amacı öykünün biçemsel özelliklerini incelemek ve Türkçeye yapılan çevirileriyle karşılaştırma yapmaktır.
Conditionals as interpersonal devices in Late Modern English women’s scientific writing
Authors: Puente-Castelo Luis
Published: July 2023

It is widely recognised that attaining best possible reception of one’s writing within the scientific community is among the main factors that contribute to the rhetorical profile of scientific prose. Authors not only have to negotiate meaning but also to persuade their peers (Allen, Qin & Lancaster, 1994; Atkinson 1996, 1999; Bazerman, 1988; Hyland, 1998, 2000). This is perhaps most remarkable when the position within the scientific community is disadvantageous, as in the case of female scientists during the Late Modern English period. (Crespo, 2012; Schiebinger, 1989, 2003).

Conditionals present an array of functions of an interpersonal nature, these used to negotiate meaning or to achieve a better reader response. Whether they are used to state shared assumptions, to narrow the scope or mitigate the force of a claim, to show humility by rhetorically doubting one’s own wording or underlining one’s uncertainty, or to directly express politeness, conditionals can be characterised as “rhetorical device[s] for gaining acceptance for one’s claims” (Warchal, 2010, p. 141).

The aim of this article is to analyse the use of conditionals as interpersonal, negotiating devices in the work of female scientists in the eighteenth and nineteenth centuries. To this end, texts written by women included in the Coruña Corpus of English Scientific Writing (Moskowich, 2011) will be searched for conditional markers, and the results will be analysed from a functional point of view, highlighting the particular ways in which female scientists used these devices across disciplines and through the period.
Whole issue 16.1
Authors: Value Language
Published: July 2023

Whole issue 16.1
Transformed or Transferred? How Workers Perceive Managerial Control over Home Telework. Some Insights from an Italian Case
Authors: Iannuzzi Francesco Eugenio , Campolongo Francesco
Published: July 2023

We examined how home-based teleworkers perceived managerial control in an Italian context in order to gain insight into some of the organizational changes brought on by the COVID-19 pandemic. Drawing on studies of changes to managerial control over the past few decades, we show how workers have experienced the reconfiguration and hybridization of control practices and methods in home telework. Our results cast doubt on the widely held belief that telework is revolutionizing managerial control and work procedures. Organizational and power dynamics at work are key to determining how telework affects employee experiences.

Summary

We investigated the impact of the COVID-19 pandemic on labour relations, specifically by examining how teleworkers perceived control within various occupations in an Italian context. Telework has long been touted as having the power to displace traditional managerial control structures in favour of less hierarchical forms of supervision. However, scholars are still divided over whether it promotes greater employee autonomy or, on the contrary, results in greater managerial control. Research has frequently been influenced by specific circumstances. In earlier decades, the low prevalence of telework encouraged neither thorough research nor the ability to compare various organizational structures. Additionally, there has been a long-standing tendency to treat teleworkers as a homogeneous group, with little regard for within-group differences. Disparities among workers and among organizations can lead to inconsistent results.

Our study was conducted mainly during the first waves of the pandemic in Italy, with a view to understanding if, how, to what extent and on what basis telework modifies managerial control processes and systems. We looked at how workers experienced managerial control in various occupations that differ in organizational form and managerial culture.

In line with Storey’s (1985) concept of “layers of control” and, more generally, with studies on transformations of managerial control in labour processes, we argue that the emergency restructuring due to home telework caused a transfer of organizational conditions, these being a combination of existing methods, standards and forms of control. Our findings show how employees dealt with the hybridization, overlapping and differentiation of various forms of control during a time of widespread telework. In this way, we cast doubt on the simplistic association between telework and reduction of control, as well as on the potential of telework to bring fundamental change to organizational processes.
Éclairage par le commun des conditions organisationnelles pour la pérennité des communautés de pratique
Authors: Pastier Kévin , Combes Victor , Dalmas Michel , Silva François
Published: July 2023

Objectif de la recherche : Cet article interroge la pérennité des communautés de pratique (CoP), généralement considérée par des approches déterministes, en utilisant le cadre théorique des communs. Cet article propose donc par analogie d’analyser les CoP en tant qu’organization et organizing. Cette approche doit permettre d’identifier les conditions internes pour une reproduction d’une CoP. L’objectif de cette recherche est ainsi de comprendre les conditions d’auto-organisation et de pérennité d’une CoP. Méthodologie : Pour ce faire, nous utilisons une méthodologie mixte. Après une étude qualitative de plusieurs mois à observer et analyser deux CoP, nous nous appuyons sur une étude quantitative menée auprès de sept CoP au sein d’une entreprise, MUTUALIS. Un questionnaire permettant d’analyser l’organization et l’organizing des CoP a été envoyé aux membres. 76 réponses ont été retenues et analysées avec SMART PLS. Contribution : Si cet article identifie un potentiel de reproduction interne des CoP et donc de pérennité, il souligne également que celle-ci demeure partielle par son usage instrumental. En raison de ce dernier, les CoP minimisent leur reproduction organisationnelle et donc leur auto-organisation. Pour dépasser cette limite, le cadre du commun propose in fine une approche intégrative de l’organisation d’une action collective auto-organisée qui nous amène à penser la démocratisation à une échelle multiniveaux. Finalement, cette étude démontre l’impératif d’une transformation organisationnelle plus générale de l’entreprise qui ne peut être réduite à des dispositifs ou des communautés sporadiques.

Précis

Les communautés de pratique (CoP) semblent aujourd’hui amplement étudiées par la littérature académique depuis une vingtaine d’années, en particulier leur rôle en knowledge management. Cependant, parfois considérées comme des formes auto-organisées et émancipatrices au sein de l’entreprise, les approches traditionnellement développées concernant leur pérennité nous semblent discutables. Elles proposent en effet une conception déterministe : les CoP sont vouées à dégénérer, soit à se banaliser par contrôle de la structure managériale soit par banalisation interne. Cet article propose alors une relecture de la pérennité des CoP, à l’aide d’une approche renouvelée en sciences de gestion et non déterministe de l’action collective organisée : les communs.
Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism
Authors: Caveney Nathanael A , Tsutsumi Naotaka , Garcia K Christopher
Published: July 2023

Membrane receptor guanylyl cyclases play a role in many important facets of human physiology, from regulating blood pressure to intestinal fluid secretion. The structural mechanisms which influence these important physiological processes have yet to be explored. We present the 3.9 Å resolution cryo-EM structure of the human membrane receptor guanylyl cyclase GC-C in complex with Hsp90 and its co-chaperone Cdc37, providing insight into the mechanism of Cdc37 mediated binding of GC-C to the Hsp90 regulatory complex. As a membrane protein and non-kinase client of Hsp90–Cdc37, this work shows the remarkable plasticity of Cdc37 to interact with a broad array of clients with significant sequence variation. Further, this work shows how membrane receptor guanylyl cyclases hijack the regulatory mechanisms used for active kinases to facilitate their regulation. Given the known druggability of Hsp90, these insights can guide the further development of membrane receptor guanylyl cyclase-targeted therapeutics and lead to new avenues to treat hypertension, inflammatory bowel disease, and other membrane receptor guanylyl cyclase-related conditions.
The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
Authors: Li Yanqiu , Wang Feifei , Li Xin , Wang Ling , Yang Zheng , You Zhongsheng , Peng Aimin
Published: July 2023

Checkpoint activation after DNA damage causes a transient cell cycle arrest by suppressing CDKs. However, it remains largely elusive how cell cycle recovery is initiated after DNA damage. In this study, we discovered the upregulated protein level of MASTL kinase hours after DNA damage. MASTL promotes cell cycle progression by preventing PP2A/B55-catalyzed dephosphorylation of CDK substrates. DNA damage-induced MASTL upregulation was caused by decreased protein degradation, and was unique among mitotic kinases. We identified E6AP as the E3 ubiquitin ligase that mediated MASTL degradation. MASTL degradation was inhibited upon DNA damage as a result of the dissociation of E6AP from MASTL. E6AP depletion reduced DNA damage signaling, and promoted cell cycle recovery from the DNA damage checkpoint, in a MASTL-dependent manner. Furthermore, we found that E6AP was phosphorylated at Ser-218 by ATM after DNA damage and that this phosphorylation was required for its dissociation from MASTL, the stabilization of MASTL, and the timely recovery of cell cycle progression. Together, our data revealed that ATM/ATR-dependent signaling, while activating the DNA damage checkpoint, also initiates cell cycle recovery from the arrest. Consequently, this results in a timer-like mechanism that ensures the transient nature of the DNA damage checkpoint.
Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion Loop
Authors: Meganck Rita M. , Zhu Deanna , Dong Stephanie , Snoderly-Foster Lisa J. , Dalben Yago R. , Thiono Devina , White Laura J. , DeSilva Aravinda M. , Baric Ralph S. , Tse Longping V.
Published: July 2023

A hallmark of Dengue virus (DENV) pathogenesis is the potential for antibody-dependent enhancement, which is associated with deadly DENV secondary infection, complicates the identification of correlates of protection, and negatively impacts the safety and efficacy of DENV vaccines. Antibody-dependent enhancement is linked to antibodies targeting the fusion loop (FL) motif of the envelope protein, which is completely conserved in mosquito-borne flaviviruses and required for viral entry and fusion. In the current study, we utilized saturation mutagenesis and directed evolution to engineer a functional variant with a mutated fusion-loop (D2-FL) which is not neutralized by fusion-loop-targeting monoclonal antibodies. The fusion-loop mutations were combined with our previously evolved pre-membrane cleavage site to create a mature version of D2-FL (D2-FLM), which evades both pre-membrane and fusion-loop antibodies but retains sensitivity to other type-specific and quaternary cross-reactive antibodies. Cross-reactive serum from heterotypic (DENV4) infected non-human primates showed lower neutralization titers against D2-FL and D2-FLM than isogenic wildtype DENV2 while similar neutralization titers were observed in serum from homotypic (DENV2) infected non-human primates. We propose D2-FL and D2-FLM as valuable tools to delineate cross-reactive antibody subtypes in serum as well as an exciting platform for safer live attenuated DENV vaccines suitable for naïve individuals and children.
Recursive self-embedded vocal motifs in wild orangutans
Authors: Lameira Adriano R , Hardus Madeleine E , Ravignani Andrea , Raimondi Teresa , Gamba Marco
Published: July 2023

Recursive procedures that allow placing a vocal signal inside another of a similar kind provide a neuro-computational blueprint for syntax and phonology in spoken language and human song. There are, however, no known vocal sequences among nonhuman primates arranged in self-embedded patterns that evince vocal recursion or potential incipient or evolutionary transitional forms thereof, suggesting a neuro-cognitive transformation exclusive to humans. Here, we uncover that wild flanged male orangutan long calls feature rhythmically isochronous call sequences nested within isochronous call sequences, consistent with two hierarchical strata. Remarkably, three temporally and acoustically distinct call rhythms in the lower stratum were not related to the overarching rhythm at the higher stratum by any low multiples, which suggests that these recursive structures were neither the result of parallel non-hierarchical procedures nor anatomical artifacts of bodily constraints or resonances. Findings represent a case of temporally recursive hominid vocal combinatorics in the absence of syntax, semantics, phonology, or music. Second-order combinatorics, ‘sequences within sequences’, involving hierarchically organized and cyclically structured vocal sounds in ancient hominids may have preluded the evolution of recursion in modern language-able humans.
Myomatrix arrays for high-definition muscle recording
Authors: Chung Bryce , Zia Muneeb , Thomas Kyle A , Michaels Jonathan A , Jacob Amanda , Pack Andrea , Williams Matthew J , Nagapudi Kailash , Teng Lay Heng , Arrambide Eduardo , Ouellette Logan , Oey Nicole , Gibbs Rhuna , Anschutz Philip , Lu Jiaao , Wu Yu , Kashefi Mehrdad , Oya Tomomichi , Kersten Rhonda , Mosberger Alice C , O'Connell Sean , Wang Runming , Marques Hugo , Mendes Ana Rita , Lenschow Constanze , Kondakath Gayathri , Kim Jeong Jun , Olson William , Quinn Kiara N , Perkins Pierce , Gatto Graziana , Thanawalla Ayesha , Coltman Susan , Kim Taegyo , Smith Trevor , Binder-Markey Ben , Zaback Martin , Thompson Christopher K , Giszter Simon , Person Abigail , Goulding Martyn , Azim Eiman , Thakor Nitish , O'Connor Daniel , Trimmer Barry , Lima Susana Q , Carey Megan R , Pandarinath Chethan , Costa Rui M , Pruszynski J Andrew , Bakir Muhannad , Sober Samuel J
Published: July 2023

Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system’s actual motor output – the activation of muscle fibers by motor neurons – typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups. Here we present a novel class of electrode devices (‘Myomatrix arrays’) that record muscle activity at unprecedented resolution across muscles and behaviors. High-density, flexible electrode arrays allow for stable recordings from the muscle fibers activated by a single motor neuron, called a ‘motor unit,’ during natural behaviors in many species, including mice, rats, primates, songbirds, frogs, and insects. This technology therefore allows the nervous system’s motor output to be monitored in unprecedented detail during complex behaviors across species and muscle morphologies. We anticipate that this technology will allow rapid advances in understanding the neural control of behavior and identifying pathologies of the motor system.
Myomatrix arrays for high-definition muscle recording
Authors: Chung Bryce , Zia Muneeb , Thomas Kyle , Michaels Jonathan A. , Jacob Amanda , Pack Andrea , Williams Matt , Nagapudi Kailash , Teng Lay Heng , Arrambide Eduardo , Ouellette Logan , Oey Nicole , Gibbs Rhuna , Anschutz Philip , Lu Jiaao , Wu Yu , Kashefi Mehrdad , Oya Tomomichi , Kersten Rhonda , Mosberger Alice , O’Connell Sean , Wang Runming , Marques Hugo , Mendes Ana Rita , Lenschow Constanze , Kondakath Gayathri , Kim Jeong Jun , Olson William , Quinn Kiara , Perkins Pierce , Gatto Graziana , Thanawalla Ayesha , Coltman Susan , Kim Taegyo , Smith Trevor , Binder-Markey Ben , Zaback Martin , Thompson Christopher K. , Giszter Simon , Person Abigail , Goulding Martyn , Azim Eiman , Thakor Nitish , O’Connor Daniel , Trimmer Barry , Lima Susana Q. , Carey Megan , Pandarinath Chethan , Costa Rui M. , Pruszynski J. Andrew , Bakir Muhannad , Sober Samuel J.
Published: July 2023

Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system’s actual motor output – the activation of muscle fibers by motor neurons – typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups. Here we present a novel class of electrode devices (“Myomatrix arrays”) that record muscle activity at cellular resolution across muscles and behaviors. High-density, flexible electrode arrays allow for stable recordings from the muscle fibers activated by a single motor neuron, called a “motor unit”, during natural behaviors in many species, including mice, rats, primates, songbirds, frogs, and insects. This technology therefore allows the nervous system’s motor output to be monitored in unprecedented detail during complex behaviors across species and muscle morphologies. We anticipate that this technology will allow rapid advances in understanding the neural control of behavior and in identifying pathologies of the motor system.
I-Spin live, an open-source software based on blind-source separation for real-time decoding of motor unit activity in humans
Authors: Rossato Julien , Hug François , Tucker Kylie , Gibbs Ciara , Lacourpaille Lilian , Farina Dario , Avrillon Simon
Published: July 2023

Decoding the activity of individual neural cells during natural behaviours allows neuroscientists to study how the nervous system generates and controls movements. Contrary to other neural cells, the activity of spinal motor neurons can be determined non-invasively (or minimally invasively) from the decomposition of electromyographic (EMG) signals into motor unit firing activities. For some interfacing and neuro-feedback investigations, EMG decomposition needs to be performed in real time. Here, we introduce an open-source software that performs real-time decoding of motor neurons using a blind-source separation approach for multichannel EMG signal processing. Separation vectors (motor unit filters) are optimised for each motor unit from baseline contractions and then re-applied in real time during test contractions. In this way, the firing activity of multiple motor neurons can be provided through different forms of visual feedback. We provide a complete framework with guidelines and examples of recordings to guide researchers who aim to study movement control at the motor neuron level. We first validated the software with synthetic EMG signals generated during a range of isometric contraction patterns. We then tested the software on data collected using either surface or intramuscular electrode arrays from five lower limb muscles (gastrocnemius lateralis and medialis, vastus lateralis and medialis, and tibialis anterior). We assessed how the muscle or variation of contraction intensity between the baseline contraction and the test contraction impacted the accuracy of the real-time decomposition. This open-source software provides a set of tools for neuroscientists to design experimental paradigms where participants can receive real-time feedback on the output of the spinal cord circuits.
Automated cell annotation in multi-cell images using an improved CRF_ID algorithm
Authors: Lee Hyun Jee , Liang Jingting , Chaudhary Shivesh , Moon Sihoon , Yu Zikai , Wu Taihong , Liu He , Choi Myung-Kyu , Zhang Yun , Lu Hang
Published: July 2023

Cell identification is an important yet difficult process in data analysis of biological images. Previously, we developed an automated cell identification method called CRF_ID and demonstrated its high performance in
C. elegans
whole-brain images (Chaudhary et al, 2021). However, because the method was optimized for whole-brain imaging, comparable performance could not be guaranteed for application in commonly used
C. elegans
multi-cell images that display a subpopulation of cells. Here, we present an advance CRF_ID 2.0 that expands the generalizability of the method to multi-cell imaging beyond whole-brain imaging. To illustrate the application of the advance, we show the characterization of CRF_ID 2.0 in multi-cell imaging and cell-specific gene expression analysis in
C. elegans
. This work demonstrates that high accuracy automated cell annotation in multi-cell imaging can expedite cell identification and reduce its subjectivity in
C. elegans
and potentially other biological images of various origins.
A three-dimensional geometric morphometric analysis of the morphological transformation of Caiman lower jaw during post-hatching ontogeny
Authors: Fernandez Blanco María Victoria , Cassini Guillermo Hernán , Bona Paula
Published: July 2023

Shape ontogenetic changes of the lower jaw in crocodylians are poorly understood. In order to answer some questions related to the inter- and intraspecific morphological variation of the mandible of two extant Caiman species, we performed a three-dimensional geometric morphometric approach. For this purpose, we used landmarks and semilandmarks on two ontogenetic mandibular series of 48 and 15 post-hatching specimens of C. yacare and C. latirostris, respectively. We have also examined the relationship between these anatomical transformations and ontogenetic shifts in diet. We performed a principal component analysis (PCA) for the two species, and regression and partial least squares (PLS) analyses for each species, separately. As a result, species were segregated along the PC1 with specimens of C. yacare showing more gracile mandibles, and specimens of C. latirostris more robust ones. The PC2 and regression analyses showed an age gradient and represented ontogenetic shape changes. Adult caiman mandibles are higher and wider than juvenile ones, and shape changes are more conspicuous in C. latirostris. The PLS analyses showed a significant relationship between shape and diet. Morphological changes of the PLS1 of block-1 match with those of the regression analysis for both species. We have detected morphological transformations in areas where the musculature in charge of mandibular movements is attached. Common morphological changes occurring during ontogeny seem to reflect the same mechanical properties required for crushing and killing in both species, driven by an ontogenetic shift in the diet from invertebrates to vertebrates. Additionally, interspecific differences were also found to be correlated to ontogenetic changes in diet and could be related to dissimilar feeding mechanical requirements (e.g., stiffness and toughness of the item consumed), and to different habitat preferences. Robust mandibles would be more suitable for shallow and fully vegetated environments, as it can be seen in C. latirostris, whereas slender jaws seem to be more suitable for more aquatic species such as C. yacare.
Estudo de melhorias em habitação de interesse social visando a sustentabilidade
Authors: Miranda João Pedro Souza , Ribeiro Sidnea Eliane Campos , De Oliveira Danielle Meireles , Ribeiro Maria Carmen Couto , Almeida Marys Lene Braga , Bamberg Paula , Teixeira Thayza Mendes
Published: July 2023

Para o efetivo cumprimento da função social das habitações de interesse social (HIS), faz-se necessária a adoção de medidas que garantam a sustentabilidade do conjunto habitacional. Este estudo analisa a realidade de unidades habitacionais já existentes construídas sem a devida atenção com as propostas do conceito de sustentabilidade. Através desse estudo, são propostas ações que compõe uma diretriz geral para a melhoria dos aspectos ambientais e socioculturais analisados contribuindo para a verdadeira aplicação do tripé da sustentabilidade: ambiente, economia e cultura. Esse estudo busca entender a influência do pensamento sustentável na realidade vivida em HIS, de modo a identificar as lacunas existentes a fim de mitigá-las com as diretrizes propostas. Através desse estudo, foi possível identificar as lacunas existentes na ligação entre a habitação de interesse social e sustentabilidade. Desse modo, as diretrizes aqui apresentadas atuam diretamente no ponto ressaltado e foram construídas com embasamento dos dados presentes na literatura e com levantamento realizado em conjuntos habitacionais de Belo Horizonte. Assim, é possível estabelecer um modelo para melhorias no bem-estar e na vida dos moradores de baixa renda moradores de das HIS.
Awareness and Practice of Good Manufacturing Practices (GMP) among Street Food Vendors in Catarman, Northern Samar
Authors: Madario Mary Jane , Pulga Hannah Lea G. , Lim Karina Milagros C. , Dagalea Flyndon Mark S.
Published: July 2023

Street food vendors play a crucial role in providing affordable and convenient food options, especially for those who need to purchase necessities in small quantities. However, ensuring food safety in these informal food businesses remains a major concern. This study aims to investigate the level of awareness and practices of good manufacturing practices among street food vendors in Catarman, Northern Samar. Using a combination of descriptive quantitative and qualitative approaches, the researchers conducted interviews with vendors at the University of Eastern Philippines Main Campus. A survey questionnaire was administered to gather accurate information, while simultaneous observations of the vendors' operations were conducted. Data analysis involved tallying, frequency calculation, percentage determination, and mean calculation. It was found that despite belonging to a single association, the vendors employed different food safety practices in their businesses. The findings highlight the importance of enhancing food safety knowledge among street food vendors and implementing effective measures to prevent food-borne illnesses. This study contributes to the body of knowledge on the subject and offers valuable insights for policymakers and regulatory agencies in improving food safety practices within the street food sector.
Climate Risk Management at Farmer’s Field through Adaptation Strategies for Resource-Poor Farmers of Assam, Northeast India
Authors: Sarma Pallab Kumar , Borah Rupam , Borah Rupshree , Chary G. Ravindra , Baruah Nikhilesh , Neog Prasanta , Sonowal Arunjyoti , Deka Sobha Dutta , Kalita Rekhashree , Dutta Samiran , Bhattacharyya Ashok
Published: July 2023

Farmers in Assam's North Bank Plains Zone are generally resource-poor and have limited adaptation ability; rainfall anomalies make the Zone's rainfed agriculture very sensitive, risky, and unprofitable. Participatory on-farm trials involving 25 farmers (5 from each village) representing different land situations for evaluating various adaptive strategies on rice-based cropping systems were conducted from 2011 to 2020. Ten years of rainfall data (2011-2021) are evaluated in connection to dry spells and their effects on rainfed rice-based farming systems. The village receives 2848.5 mm of annual rainfall, with distribution patterns of 25%, 67%, 5.0%, and 3% during the pre-monsoon, monsoon, post-monsoon, and winter seasons, respectively. Among the years under study, it has been observed that during 2010, 2015, 2016, 2017 and 2020, the district received excess annual rainfall and deficit in 2011, 2012, 2013, 2014, 2018, 2019 and 2021,respectively. The current studies were designed with two primary strategic components in mind viz., Real-time Contingency Planning (RTCP) and Preparedness. Interventions under the RTCP were designed to deal with delayed monsoon onset, early-season drought, mid-season dryspell, and terminal drought in winter rice and rabi crops. Preparedness includes changes in cropping pattern, in situ and ex situ rainwater management systems, alternate land use under low-cost polyhouse, mushroom cultivation, vermicompost production, fodder bank and village seed bank to cope with weather aberrations. An increase in yield of HYV rice varieties Ranjit (33%), Mahsuri (12.3%) and Gitesh (32%) was observed when sowing was done before 15 June over late sowing conditions. An increase in yield of 21.73 % and 44.60%. 58.67% as compared to farmers' Practice during 2013-14, 2014-15, and 2016-17 respectively, has been observed. The performance of double cropping systems recorded the highest B: C ratio of 2.03 and 1.75 in winter rice + rapeseed followed by winter rice + potato sequence as compared to mono-cropping of winter rice.
Effect of Irrigation Regimes and Mulching on the Crop Physiology and Yield of Rabi Maize (Zea mays)
Authors: Ahirwar S. , Subbaiah R. , Gupta P. , Tiwari M. K. , Trivedi M. M. , Vaishnav P.
Published: July 2023

Agriculture is a vital sector of India’s economy and plays a significant role in providing food security, employment, and contributing to the country’s overall development. Maize is a crucial crop within the agriculture sector in India. Maize cultivation contributes to crop diversification in Indian agriculture. It serves as an alternative crop option for farmers, reducing dependence on traditional crops like rice and wheat. Diversification helps in maintaining soil health through crop rotation. A field experiment was conducted at the Farm of College of Agricultural Engineering and Technology, Godhra, Gujarat during the year 2018-19, to study the influence of drip irrigation regimes with mulching on the physiological development and yield of the rabi maize (Zea mays L.) in the sandy loam soil of the region of Middle Gujarat. The field experiment design was a split-split plot with 36 treatment combinations with 3 replications including three irrigation regimes (1.0IW/CPE, 0.8IW/CPE and 0.6IW/CPE), four mulch conditions (control, paddy straw, black plastic and reflective silver plastic mulch), and three stages (tasselling, silking and dough stage). The result revealed that as the consumption of water increased, growth parameters, grain yield, and its attributes increased significantly at each higher level of irrigation regimes up to 1.0 IW/CPE with reflective silver plastic mulch under all the stages but 0.8 IW/CPE with black plastic mulch result was comparable to 1.0 IW/CPE with reflective silver plastic mulch. The reflective nature of silver mulch scatters light, ensuring better light distribution throughout the plant canopy. This can enhance photosynthesis and promote more uniform plant growth. Black plastic mulch absorbs and retains heat from sunlight, raising soil temperatures. This is advantageous in cooler climates or during the early growing season, as it promotes earlier germination, faster growth, and improved crop productivity.
Effect of Varieties and Organic Manure on Growth and Yield of Rice (Oryza sativa L.)
Authors: Anvesh Vage , Mehera Biswarup , Kumar Prateek
Published: July 2023

The field experiment was conducted during kharif 2022 at Crop Research Farm, Department of Agronomy, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj (U.P). The soil texture of experimental plot was sandy loam neutral in soil reaction (pH 7.1), low in organic carbon (0.36 %), available N (171.48 kg/ha), available P (15.2 kg/ha) and available K (232.5 kg/ha). The experiment was laid out in Randomized Block Design (RBD) with nine treatments including control each replicated thrice based on one year experimentation. The treatments consist of T1: NDR 359 + FYM 10t/ha, T2: NDR 359 + Poultry manure 2t/ha, T3: NDR 359 + Vermicompost 5t/ha, T4: Sahbhgi Dhan + FYM 10t/ha, T5: Sahbhgi Dhan + Poultry manure 2t/ha, T6: Sahbhgi Dhan + Vermicompost 5t/ha, T7: Arize 6444 + FYM 10t/ha, T8: Arize 6444 + Poultry manure 2t/ha, T9: Arize 6444 + Vermicompost 5t/ha are used. The application of NDR 359 + Poultry manure 2t/ha recorded significantly higher Plant height (107.67 cm), Number of tillers/hill (15.90), Plant dry weight (88.03 g/hill), maximum panicles/hill (10.67), number of grains/panicle (98.70), Test weight (20.68 g), grain yield (5.40 t/ha), straw yield (7.07 t/ha), Harvest index (43.31 %). Higher gross returns (1,66,674.00 INR/ha), net return (1,10,314.2 INR/ha) and benefit cost ratio (1.96) was obtained in the treatment of NDR 359 + Poultry manure 2t/ha.
Acute and Long-Term Outcomes of Hypertensive Crisis and Hypertensive Emergency in Patients Accompanied by Orthostatic Hypotension
Authors: Hayrab Chuker
Published: July 2023

Introduction: Hypertensive crisis and hypertensive emergency are urgent medical conditions characterized by severely elevated blood pressure levels, often exceeding systolic values of 180 mmHg and/or diastolic values of 120 mmHg. The acute outcomes of hypertensive crisis and hypertensive emergency in patients with orthostatic hypotension include an increased risk of cerebrovascular events, such as ischemic and hemorrhagic strokes, as well as myocardial infarction.

Review of Literature: Orthostatic hypotension has been associated with various adverse outcomes, including syncope, stroke, CVD, and mortality. However, the effects of interventions targeting OH have yet to be extensively reported. It is important to understand the long-term outcomes in individuals with orthostatic hypotension and hypertensive episodes, but not many studies have shed light on this complex clinical scenario. The only literature available focuses on the mortality and morbidity of orthostatic hypotension rather than the outcomes of superimposed hypertensive urgency.

Discussion: The study reported secondary outcomes such as readmission rates, in-hospital mortality, stroke, acute kidney injury, and other complications. The study suggests that focusing on preventing orthostatic hypotension symptoms while tolerating some degree of supine hypertension may be a reasonable approach to management.

Conclusion: Influence the relationship between orthostatic hypotension and hypertensive emergencies. These conditions further complicate the management and outcomes of hypertensive crises and emergencies.
Application and Prospect of Wave Energy in Marine Robots
Authors: Chuan Liu , Shifeng Yuan
Published: July 2023

Marine robots are an important tool for developing and exploring the ocean, which can adapt and work in the harsh marine environment. However, energy supply is one of the important factors that limit the operational capabilities of marine robots, and obtaining energy from the marine environment is an important way to improve the operating time and scope of marine robots. Wave energy is the most widely distributed in the ocean, with high energy flow density and easy to develop renewable clean energy. Therefore, wave energy can be used to provide energy for marine robots. Wave energy provides the possibility to solve the problem between the basic endurance and limited energy of marine robots. This paper introduces wave energy, summarizes the application of wave energy in marine robots, and analyzes its development trend, so as to provide reference for energy research of marine robots.