bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphological Description and Classification of Wheat Kernels Based on Geometric Models
Authors: Martín-Gómez José Javier , Rewicz Agnieszka , Goriewa-Duba Klaudia , Wiwart Marian , Tocino Ángel , Cervantes Emilio
Published: July 2019

Modern automated and semi-automated methods of shape analysis depart from the coordinates of the points in the outline of a figure and obtain, based on artificial vision algorithms, descriptive parameters (i.e., the length, width, area, and circularity index). These methods omit an important factor: the resemblance of the examined images to a geometric figure. We have described a method based on the comparison of the outline of seed images with geometric figures. The J index is the percentage of similarity between a seed image and a geometric figure used as a model. This allows the description and classification of wheat kernels based on their similarity to geometric models. The figures used are the ellipse and the lens of different major/minor axis ratios. Kernels of different species, subspecies and varieties of wheat adjust to different figures. A relationship is found between their ploidy levels and morphological type. Kernels of diploid einkorn and ancient tetraploid emmer varieties adjust to the lens and have curvature values in their poles superior to modern “bread” varieties. Kernels of modern varieties (hexaploid common wheat) adjust to an ellipse of aspect ratio = 1.6, while varieties of tetraploid durum and Polish wheat and hexaploid spelt adjust to an ellipse of aspect ratio = 2.4.
Comparative Transcriptome Analysis of Streptomyces Clavuligerus in Response to Favorable and Restrictive Nutritional Conditions
Authors: Pinilla Laura , Toro León F. , Laing Emma , Alzate Juan Fernando , Ríos-Estepa Rigoberto
Published: July 2019

Background: Clavulanic acid (CA), a β-lactamase inhibitor, is industrially produced by the fermentation of Streptomyces clavuligerus. The efficiency of CA production is associated with media composition, culture conditions and physiological and genetic strain characteristics. However, the molecular pathways that govern CA regulation in S. clavuligerus remain unknown. Methods and Results: Here we used RNA-seq to perform a comparative transcriptome analysis of S. clavuligerus ATCC 27064 wild-type strain grown in both a favorable soybean-based medium and in limited media conditions to further contribute to the understanding of S. clavuligerus metabolism and its regulation. A total of 350 genes were found to be differentially expressed between conditions; 245 genes were up-regulated in favorable conditions compared to unfavorable. Conclusion: The up-regulated expression of many regulatory and biosynthetic CA genes was positively associated with the favorable complex media condition along with pleiotropic regulators, including proteases and some genes whose biological function have not been previously reported. Knowledge from differences between transcriptomes from complex/defined media represents an advance in the understanding of regulatory paths involved in S. clavuligerus’ metabolic response, enabling the rational design of future experiments.
Degradation of UV Filter Ethyl 4-Aminobenzoate (Et-PABA) Using a UV-Activated Persulfate Oxidation Process
Authors: Han Ruirui , Wu Qiang , Lin Chihao , Zhang Lingfeng , Zhai Zhicai , Sun Ping , Fang Yingsen , Wu Jiaqiang , Liu Hui
Published: July 2019

In this paper, the ultraviolet/persulfate (UV/PDS) combined oxidation process was used to remove the ethyl 4-aminobenzoate (Et-PABA), one of the typical 4-aminobenzoic acid (PABA)-type UV filters. The effects of various factors on the removal of Et-PABA using the UV/PDS process were investigated, and the degradation mechanisms of Et-PABA were explored. The results showed that the UV/PDS process can effectively remove 98.7% of Et-PABA within 30 min under the conditions: UV intensity of 0.92 mW·cm−2, an initial concentration of Et-PABA of 0.05 mM, and a PDS concentration of 2 mM. The removal rate of Et-PABA increased with the increase in PDS dosage within the experimental range, whereas humic acid (HA) had an inhibitory effect on Et-PABA removal. Six intermediates were identified based on HPLC–MS and degradation pathways were then proposed. It can be foreseen that the UV/PDS oxidation process has broad application prospects in water treatment.
Physics of Within-Tissue Wave Propagation Generated by Pulse Propagation in the Carotid Artery
Authors: Tommasin Daniela , Caenen Annette , Verhegghe Benedict , Greenwald Steve , Segers Patrick
Published: July 2019

(1) Background: We aimed to assess the validity of laser Doppler vibrometry (LDV) as an emerging method to measure the local pulse wave velocity (PWV) from skin displacement generated by the pressure pulse inside an underlying artery. (2) Methods: A finite element model representing a simplified common carotid artery embedded within a soft tissue mimicking material was used to reproduce how tissue motions due to a wave propagation along the artery radiates to the skin surface. A parametric study was set up, varying: (i) the pressure conditions inside the artery (shock and traveling pressure impulse), (ii) the arterial depth and (iii) the geometry in a patient-specific artery model. (3) Results: under all conditions, the arterial pulse induced primary and secondary waves at the skin surface; of which the propagation speed deviated from the imposed PWV (deviations between −5.0% to 47.0% for the primary wave front). (4) Conclusions: the propagation of a short pressure impulse induced complex skin displacement patterns revealing a complicated link between PWV and measured propagation speeds at the skin surface. Wave propagation at the skin level may convey information about arterial PWV, however, advanced signal analysis techniques will be necessary to extract local PWV values.
Process Innovation and Improvement Using Business Object-Oriented Process Modelling (BOOPM) Framework
Authors: Venkatraman Sitalakshmi , Venkatraman Ramanathan
Published: July 2019

In the past decades, a number of methodologies have been proposed to innovate and improve business processes that play an important role in enhancing the operational efficiency of an organisation in order to attain business competitiveness. Traditional business process modelling (BPM) approaches are process-centric and focus on the workflow, ignoring the data modelling aspects that are essential for today’s data-centric landscape of modern businesses. Hence, a majority of BPM initiatives have failed in several organisations due to the lack of data-driven insights into their business performance. On the other hand, the information systems of today focus more on dataflows using object-oriented modelling (OOM) approaches. Even standard OOM approaches, such as unified modelling language (UML) methods, exhibit inherent weaknesses due to their lack of formalized innovation with business objects and the dynamic control-flows of complex business processes. In addition to these issues, both BPM and OOM approaches have been augmented with an array of complex software tools and techniques which have confused businesses. There is a lack of a common generalized framework that integrates the well-formalised control-flow based BPM approach and the dataflow based OOM approach that is suitable for today’s enterprise systems in order to support organisations to achieve successful business process improvements. This paper takes a modest step to fill this gap. We propose a framework using a structured six-step business process modelling (BPM) guideline combined with a business object-oriented methodology (BOOM) in a unique and practical way that could be adopted for improving an organisation’s process efficiency and business performance in contemporary enterprise systems. Our proposed business object-oriented process modelling (BOOPM) framework is applied to a business case study in order to demonstrate the practical implementation and process efficiency improvements that can be achieved in enterprise systems using such a structured and integrated approach.
Impacts of Aerosol Copper on Marine Phytoplankton: A Review
Authors: Yang Tianjiao , Chen Ying , Zhou Shengqian , Li Haowen
Published: July 2019

Atmospheric deposition brings both nutrients and toxic components to the surface ocean, resulting in important impacts on phytoplankton. Field and lab studies have been done on the iron (Fe) fertilization on marine phytoplankton. However, studies on other trace metals are limited. Both bioassay experiments and field observations have suggested that aerosols with high copper (Cu) concentrations can negatively affect the primary productivity and change phytoplankton community structure. Note that with increasing human activities and global environmental changes (e.g., ocean acidification, warming, deoxygenation, etc.), the input of aerosol Cu could exceed toxicity thresholds at certain times or in some sensitive oceanic regions. Here, we provide a comprehensive review on aerosol Cu and marine phytoplankton studies by summarizing (1) physiological effects and toxicity thresholds of Cu to various phytoplankton taxa, (2) interactions between Cu and other metals and major nutrients, and (3) global distribution of surface seawater Cu and atmospheric Cu. We suggest that studies on aerosols, seawater chemistry, and phytoplankton should be integrated for understanding the impacts of aerosol Cu on marine phytoplankton, and thereafter the air–sea interaction via biogeochemical processes.
Anti-Neuroinflammatory Effect of Alantolactone through the Suppression of the NF-κB and MAPK Signaling Pathways
Authors: Tan Liwei , Li Jinsheng , Wang Yeye , Tan Rui
Published: July 2019

Neuroinflammation is a major cause of central nervous system (CNS) damage and can result in long-term disability and mortality. Therefore, the development of effective anti-neuroinflammatory agents for neuroprotection is vital. To our surprise, the naturally occurring molecule alantolactone (Ala) was reported to significantly inhibit tumor growth and metastasis as a result of its excellent anti-inflammatory effects. Thus, we proposed that it could also act as an anti-neuroinflammatory agent. Thus, in this study, a coculture system of BV2 cells and PC12 cells were used as an in vitro neuroinflammatory model to investigate the anti-neuroinflammatory mechanism of Ala. The results indicated that Ala downregulated the expression of proinflammatory factors by suppressing the nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Further evaluation using a middle cerebral artery occlusion and reperfusion (MCAO/R) rat model supported the conclusion that Ala could (1) alleviate cerebral ischemia-reperfusion injury; (2) reduce neurological deficits, cerebral infarct volume, and brain edema; and (3) attenuate the apoptosis and necrosis of neurons. In sum, Ala demonstrates anti-neuroinflammatory properties that contribute to the amelioration of CNS damage, and it could be a promising candidate for future applications in CNS injury treatment.
High Temperature Anti-Friction Behaviors of a-Si:H Films and Counterface Material Selection
Authors: Zeng Qunfeng , Qin Liguo
Published: July 2019

In the present paper, the influence of self-mated friction materials on the tribological properties of hydrogenated amorphous silicon films (a-Si:H films) is studied systemically at high temperature. The results are obtained by comparing the tribological properties of a-Si:H films under different friction pair materials and temperatures. The a-Si:H films exhibit super-low friction of 0.07 at a temperature of 600 °C, and ceramic materials are appropriate for anti-friction behaviors of a-Si:H films at high temperature. The results of tribotests and observations of the fundamental friction mechanism show that super-low friction of a-Si:H films and ceramic materials of the friction system are involved in high temperature oxidation; this also applies to the tribochemical reactions of a-Si:H films, steel and iron silicate in open air at elevated temperature in the friction process.
A Review on Computational Modeling Tools for MOF-Based Mixed Matrix Membranes
Authors: Keskin Seda , Alsoy Altinkaya Sacide
Published: July 2019

Computational modeling of membrane materials is a rapidly growing field to investigate the properties of membrane materials beyond the limits of experimental techniques and to complement the experimental membrane studies by providing insights at the atomic-level. In this study, we first reviewed the fundamental approaches employed to describe the gas permeability/selectivity trade-off of polymer membranes and then addressed the great promise of mixed matrix membranes (MMMs) to overcome this trade-off. We then reviewed the current approaches for predicting the gas permeation through MMMs and specifically focused on MMMs composed of metal organic frameworks (MOFs). Computational tools such as atomically-detailed molecular simulations that can predict the gas separation performances of MOF-based MMMs prior to experimental investigation have been reviewed and the new computational methods that can provide information about the compatibility between the MOF and the polymer of the MMM have been discussed. We finally addressed the opportunities and challenges of using computational studies to analyze the barriers that must be overcome to advance the application of MOF-based membranes.
Continuous and Stable Cross-Eye Jamming via a Circular Retrodirective Array
Authors: Liu Tianpeng , Wei Xizhang , Liu Zhen , Guan Zhiqiang
Published: July 2019

Cross-eye jamming is an angular deception jamming technique against monopulse radar. Multiple-element retrodirective cross-eye jamming (MRCJ) as an improved method, uses a retrodirective antenna array with multiple antenna elements in a cross-eye jammer and can obtain better jamming performance. However, the practical MRCJ system employing a linear antenna array becomes ineffective when the threat radar appears in the antenna array’s end-fire direction. To meet multiple threats from different directions and provide continuous jamming, MRCJ employing a circular antenna array (C-MRCJ) is proposed after defining the modulation direction of system parameters. Optimal configuration of C-MRCJ providing stable jamming performance is discussed. The number of the jammer loops is analyzed under considerable jamming performance and moderate hardware cost.
Integrated Optimal Design and Control of Fourth Generation District Heating Networks with Thermal Energy Storage
Authors: van der Heijde Bram , Vandermeulen Annelies , Salenbien Robbe , Helsen Lieve
Published: July 2019

In the quest to increase the share of renewable and residual energy sources in our energy system, and to reduce its greenhouse gas emissions, district heating networks and seasonal thermal energy storage have the potential to play a key role. Different studies prove the techno-economic potential of these technologies but, due to the added complexity, it is challenging to design and control such systems. This paper describes an integrated optimal design and control algorithm, which is applied to the design of a district heating network with solar thermal collectors, seasonal thermal energy storage and excess heat injection. The focus is mostly on the choice of the size and location of these technologies and less on the network layout optimisation. The algorithm uses a two-layer program, namely with a design optimisation layer implemented as a genetic algorithm and an optimal control evaluation layer implemented using the Python optimal control problem toolbox called modesto. This optimisation strategy is applied to the fictional district energy system case of the city of Genk in Belgium. We show that this algorithm can find optimal designs with respect to multiple objective functions and that even in the cheaper, less renewable solutions, seasonal thermal energy storage systems are installed in large quantities.
New Method for Calculating the Heating of the Conductor
Authors: Voršič Žiga , Maruša Robert , Pihler Jože
Published: July 2019

The paper describes the core heating of ACSR (aluminum conductor steel—reinforced) conductor in stable operation under different environmental conditions. The calculations are greatly simplified in a steady state—we can calculate on a balance of power instead of a balance of energies. At a known surface, the temperature of the conductor due to solar radiation, natural convection, and joules heating as well as the temperature of the steel core were calculated, which is relevant for the tensile strength of the rope. Measurements of the surface of the conductor and the core rejected a simple model of heat transfer—it is also necessary to take into account empty air spaces between the wires of a rope. On the basis of measurements, a new model has given satisfactory compliance with the measured values.
Comparison of Three Algorithms to Estimate Tree Stem Diameter from Terrestrial Laser Scanner Data
Authors: Ravaglia Joris , Fournier Richard A. , Bac Alexandra , Véga Cédric , Côté Jean-François , Piboule Alexandre , Rémillard Ulysse
Published: July 2019

Terrestrial laser scanners provide accurate and detailed point clouds of forest plots, which can be used as an alternative to destructive measurements during forest inventories. Various specialized algorithms have been developed to provide automatic and objective estimates of forest attributes from point clouds. The STEP (Snakes for Tuboid Extraction from Point cloud) algorithm was developed to estimate both stem diameter at breast height and stem diameters along the bole length. Here, we evaluate the accuracy of this algorithm and compare its performance with two other state-of-the-art algorithms that were designed for the same purpose (i.e., the CompuTree and SimpleTree algorithms). We tested each algorithm against point clouds that incorporated various degrees of noise and occlusion. We applied these algorithms to three contrasting test sites: (1) simulated scenes of coniferous stands in Newfoundland (Canada), (2) test sites of deciduous stands in Phalsbourg (France), and (3) coniferous plantations in Quebec, Canada. In most cases, the STEP algorithm predicted diameter at breast height with higher R2 and lower RMSE than the other two algorithms. The STEP algorithm also achieved greater accuracy when estimating stem diameter in occluded and noisy point clouds, with mean errors in the range of 1.1 cm to 2.28 cm. The CompuTree and SimpleTree algorithms respectively produced errors in the range of 2.62 cm to 6.1 cm and 1.03 cm to 3.34 cm, respectively. Unlike CompuTree or SimpleTree, the STEP algorithm was not able to estimate trunk diameter in the uppermost portions of the trees. Our results show that the STEP algorithm is more adapted to extract DBH and stem diameter automatically from occluded and noisy point clouds. Our study also highlights that SimpleTree and CompuTree require data filtering and results corrections. Conversely, none of these procedures were applied for the implementation of the STEP algorithm.
Extraction of Dairy Phospholipids Using Switchable Solvents: A Feasibility Study
Authors: Cheng Shouyun , Rathnakumar Kaavya , Martínez-Monteagudo Sergio I.
Published: July 2019

A tertiary amine (N,N-dimethylcyclohexylamine, CyNMe2) was used as a switchable hydrophilicity solvent (SHS) for extracting phospholipids (PLs) from raw cream (RC), buttermilk (BM), concentrated buttermilk (CBM), and beta-serum (BS). The SHS extractions were performed with varying solvent–sample weight ratio at room temperature. The extracted PLs using CyNMe2 were recovered by bubbling CO2 at atmospheric pressure, switching the CyNMe2 into its respective salt. For comparison, the PLs were also extracted using Folch (FE) and Mojonnier (ME) extraction. The extraction efficiency of SHS varied from 0.33% to 99%, depending on the type of byproduct. The SHS extracted up to 99% of the PLs directly from BM, while only 11.37% ± 0.57% and 2.66% ± 0.56% of the PLs were extracted with FE and ME, respectively. These results demonstrate the applicability of SHS for the extraction of PLs from dairy byproducts.
Ginseng Berry Prevents Alcohol-Induced Liver Damage by Improving the Anti-Inflammatory System Damage in Mice and Quality Control of Active Compounds
Authors: Lee Dae Young , Kim Min-Jee , Yoon Dahye , Lee Young-Seob , Kim Geum-Soog , Yoo Yung Choon
Published: July 2019

The ginseng berry contains a variety of biologically active compounds and has a higher ginsenoside content than its roots. This study focused on the hepatoprotective activity of ginseng berry extract prepared by enzyme treatment (EGB) compared to the non-enzyme-treated ginseng berry extract (GB) and quality control of EGB. The feeding effect of EGB on alcohol-induced liver damage (AILD) was investigated by measuring the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) compared with those of EtOH-fed mice. Furthermore, cytokine levels in the culture supernatants of EGB- or GB-treated RAW 264.7 cells were determined by enzyme-linked immunosorbent assay. The developed method was applied to the simultaneous quantification of four major ginsenosides in EGB using UPLC-QTOF/MS. Treatment with EGB at a dose of 0.5 or 1 mg/mouse significantly suppressed the AST and ALT levels in mice with AILD. Enzyme-treated ginseng berry was also found to suppress the production of inflammatory mediators like nitric oxide (NO), tumor-necrosis factor-α (TNF-α), interleukin-6 (IL-6), and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, showing higher activity than that of GB. The amount of ginsenoside Re, F5, F3, and Rd in the EGB obtained using UPLC-QTOF/MS was 45.9, 3.3, 4.0, and 6.2 mg/g, respectively. These results suggest that EGB has a potential effect on AILD, and its hepatoprotective effect provides beneficial insights into developing new candidates for the prevention and cure of AILD. Also, this study demonstrated the utility of UPLC-QTOF/MS-based major compounds for quality control (QC) of EGB.
Effects of Anti-Calcitonin Gene-Related Peptide for Migraines: A Systematic Review with Meta-Analysis of Randomized Clinical Trials
Authors: Huang I-Hsin , Wu Po-Chien , Lin En-Yuan , Chen Chien-Yu , Kang Yi-No
Published: July 2019

We aimed to evaluate the response rate of migraines by using anti-calcitonin gene-related peptide (anti-CGRP) for patients with migraines. We searched three main medical databases up to 29 March 2019. No restriction on language and publication time were applied. Eligible trials included randomized clinical trials investigating a 50%, 75%, and 100% response rate of migraine patients after anti-CGRP intervention. The collected data were dichotomous, and risk ratios (RRs) with a 95% confidence interval (CI) were used to present the quantitative synthesis results. The systematic review identified 16 eligible randomized clinical trials (RCTs) with 9439 patients. Eight of the 16 trials with 2516 patients reported a 50% response rate, and the pooled results showed a significant benefit from anti-CGRP. However, the effects seem to gradually reduce from the first month (RR 1.99, 95% CI 1.59 to 2.49) to the third month (RR 1.48, 95% CI 1.26 to 1.75) of treatment. The magnitude of effect was influenced by the type of anti-CGRP, according to the test for differences between subgroups (I-square = 53%). The funnel plots and Egger’s tests did not show serious small study effects in the results. In conclusion, the current evidences confirmed that anti-CGRP treatment can reduce migraine pain in the short term (within three months), but the long-term effect should be investigated in the future. Moreover, its effects may be influenced by the type and dose of anti-CGRP. Therefore, future studies should make direct comparisons among anti-CGRP medications.
Diachasmimorpha longicaudata Parasitism Response to Medfly Host Fruit and Fruit Infestation Age
Authors: Harbi Ahlem , de Pedro Luis , Ferrara Fernando A. A. , Tormos José , Chermiti Brahim , Beitia Francisco , Sabater-Munoz Beatriz
Published: July 2019

The parasitoid Diachasmimorpha longicaudata (Ashmead) (Hymenoptera: Braconidae) is increasingly being used in integrated pest management (IPM) programs as a biological control agent in order to suppress tephritid fruit flies of economic importance. Innate and acquired behavioral responses—such as pest host fruit preference—of parasitoids can modulate their efficiency in the field and should be taken into consideration prior to parasitoid species’ selection for mass-rearing. We have assessed the influence of medfly-infested (two infestation ages, 1 and 4-d-old) and uninfested fruit species on host preference and efficiency of D. longicaudata by using a multistep assay including olfactory, laboratory and semi-field trials. We found that D. longicaudata was significantly more attracted to medfly-infested apples for both infestation ages, with the oldest being the most preferred. D. longicaudata exhibited a significant preference among the four fruits tested. The implications of these behavioral responses of D. longicaudata to medfly host fruits and infestation age are discussed in relationship to its use in IPM programs in the Mediterranean basin area.
Analysis of the Effects of Day-Time vs. Night-Time Surgery on Renal Transplant Patient Outcomes
Authors: Sugünes Nesrin , Bichmann Anna , Biernath Nadine , Peters Robert , Budde Klemens , Liefeldt Lutz , Schlomm Thorsten , Friedersdorff Frank
Published: July 2019

Sleep deprivation and disruption of the circadian rhythms could impair individual surgical performance and decision making. For this purpose, this study identified potential confounding factors on surgical renal transplant patient outcomes during day and night. Our retrospective cohort study of 215 adult renal cadaver transplant recipients, of which 132 recipients were allocated in the “day-time” group and 83 recipients in the “night-time” group, primarily stratified the patients into two cohorts, depending on the start time. Within a 24 h operational system, “day-time” was considered as being from 8 a.m. to 8 p.m. and “night-time” from 8 p.m. to 8 a.m.. Primary outcomes examined patient and graft survival after three months and one year. Secondary outcomes included the presence of acute rejection (AR) and delayed graft function (DGF), as well as the rate of postoperative complications. In log-rank testing, “day-time” surgery was associated with a significantly higher risk of patient death (p = 0.003), whereas long-term graft survival was unaffected by the operative time of day. The mean cold ischemia time (CIT), which was 12.4 ± 5.3 h in the “night-time” group, was significantly longer compared to 10.7 ± 3.6 for those during the day (p = 0.01). We observed that “night-time” kidney recipients experienced more wound complications. From our single-centre data, we conclude that night-time kidney transplantation does not increase the risk of adverse events or predispose the patient to a worse outcome. Nevertheless, further research is required to explore the effect of fatigue on nocturnal surgical performance.
Long Daytime Napping Is Associated with Increased Adiposity and Type 2 Diabetes in an Elderly Population with Metabolic Syndrome
Authors: Papandreou Christopher , Díaz-López Andrés , Babio Nancy , Martínez-González Miguel A. , Bulló Mónica , Corella Dolores , Fitó Montse , Romaguera Dora , Vioque Jesús , Alonso-Gómez Ángel M. , Wärnberg Julia , Martínez Alfredo J. , Serra-Majem Lluís , Estruch Ramon , Fernández-García José C. , Lapetra José , Pintó Xavier , Tur Josep A. , Garcia-Rios Antonio , Bueno-Cavanillas Aurora , Delgado-Rodríguez Miguel , Matía-Martín Pilar , Daimiel Lidia , Martín-Sánchez Vicente , Vidal Josep , Vázquez Clotilde , Ros Emilio , Buil-Cosiales Pilar , Becerra-Tomas Nerea , Martinez-Lacruz Raul , Schröder Helmut , Konieczna Jadwiga , Garcia-de-la-Hera Manoli , Moreno-Rodriguez Anai , Barón-López Javier , Pérez-Farinós Napoleón , Abete Itziar , Bautista-Castaño Inmaculada , Casas Rosa , Muñoz-Garach Araceli , Santos-Lozano José M. , Trias Ferran , Gallardo-Alfaro Laura , Ruiz-Canela Miguel , Barragan Rocio , Goday Alberto , Galmés-Panadés Aina M. , González-Botella Andrés , Vaquero-Luna Jessica , Toledo Estefanía , Castañer Olga , Salas-Salvadó Jordi
Published: July 2019

Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly participants with overweight/obesity and metabolic syndrome, in the PREDIMED-Plus trial, was carried out. Accelerometer-derived napping was measured. Prevalence ratios (PR) and 95% confidence intervals (CI) for T2D were obtained using multivariable-adjusted Cox regression with constant time. Linear regression models were fitted to examine associations of napping with body mass index (BMI) and waist circumference (WC). Participants napping ≥90 min had a higher prevalence of T2D (PR 1.37 (1.06, 1.78)) compared with those napping 5 to <30 min per day. Significant positive associations with BMI and WC were found in those participants napping ≥30 min as compared to those napping 5 to <30 min per day. The findings of this study suggest that longer daytime napping is associated with higher T2D prevalence and greater adiposity measures in an elderly Spanish population at high cardiovascular risk.
Platelet Function Disturbance During Veno-Venous ECMO in ARDS Patients Assessed by Multiple Electrode Aggregometry—A Prospective, Observational Cohort Study
Authors: Wand Saskia , Huber-Petersen Jan Felix , Schaeper Joern , Binder Claudia , Moerer Onnen
Published: July 2019

Extracorporeal (veno-venous) membrane oxygenation (vvECMO) has been shown to have negative effects on platelet number and function. This study aimed to gain more information about the impact of vvECMO on platelet function assessed by multiple electrode aggregometry (MEA). Twenty patients with the indication for vvECMO were included. Platelet function was analyzed using MEA (Multiplate®) before (T-1), 6 h (T0), one (T1), two (T2), three (T3), and seven (T4) days after the beginning of vvECMO. Median aggregational measurements were already below the normal reference range before vvECMO initiation. Platelet aggregation was significantly reduced 6 h after vvECMO initiation compared to T-1 and spontaneously recovered with a significant increase at T2. Platelet count dropped significantly between T-1 and T0 and continuously decreased between T0 and T4. At T4, ADP-induced platelet aggregation showed an inverse correlation with the paO2 in the oxygenator. Platelet function should be assessed by MEA before the initiation of extracorporeal circulation. Although ECMO therapy led to a further decrease in platelet aggregation after 6 h, all measurements had recovered to baseline on day two. This implies that MEA as a whole blood method might not adequately reflect the changes in platelet function in the later stages of extracorporeal circulation.
Fuel Consumption and CO2 Emission Reductions of Ships Powered by a Fuel-Cell-Based Hybrid Power Source
Authors: Roh Gilltae , Kim Hansung , Jeon Hyeonmin , Yoon Kyoungkuk
Published: July 2019

The need for technological development to reduce the impact of air pollution caused by ships has been strongly emphasized by many authorities, including the International Maritime Organization (IMO). This has encouraged research to develop an electric propulsion system using hydrogen fuel with the aim of reducing emissions from ships. This paper describes the test bed we constructed to compare our electric propulsion system with existing power sources. Our system uses hybrid power and a diesel engine generator with a combined capacity of 180 kW. To utilize scale-down methodology, the linear interpolation method is applied. The proposed hybrid power source consists of a molten carbonate fuel cell (MCFC), a battery, and a diesel generator, the capacities of which are 100 kW, 30 Kw, and 50 kW, respectively. The experiments we conducted on the test bed were based on the outcome of an analysis of the electrical power consumed in each operating mode considering different types of merchant ships employed in practice. The output, fuel consumption, and CO2 emission reduction rates of the hybrid and conventional power sources were compared based on the load scenarios created for each type of ship. The CO2 emissions of the hybrid system was compared with the case of the diesel generator alone operation for each load scenario, with an average of 70%~74%. This analysis confirmed the effectiveness of using a ship with a fuel-cell-based hybrid power source.
Desiccant Films Made of Low-Density Polyethylene with Dispersed Silica Gel—Water Vapor Absorption, Permeability (H2O, N2, O2, CO2), and Mechanical Properties
Authors: Sängerlaub Sven , Kucukpinar Esra , Müller Kajetan
Published: July 2019

Silica gel is a well-known desiccant. Through dispersion of silica gel in a polymer, films can be made that absorb and desorb water vapor. The water vapor absorption becomes reversible by exposing such films to a water vapor pressure below that of the water vapor pressure during absorption, or by heating the film. The intention of this study was to achieve a better understanding about the water vapor absorption, permeability (H2O, N2, O2, CO2), and mechanical properties of films with dispersed silica gel. Low-density polyethylene (PE-LD) monolayer films with a nominal silica gel concentration of 0.2, 0.4, and 0.6 g dispersed silica gel per 1 g film (PE-LD) were prepared and they absorbed up to 0.08 g water vapor per 1 g of film. The water vapor absorption as a function of time was described by using effective diffusion coefficients. The steady state (effective) water vapor permeation coefficients of the films with dispersed silica gel were a factor of 2 to 14 (8.4 to 60.2·10−12 mg·cm·(cm2·s·Pa)−1, 23 °C) higher than for pure PE-LD films (4.3·10−12 mg·cm·(cm²·s·Pa)−1, 23 °C). On the other hand, the steady state gas permeabilities for N2, O2, and CO2 were reduced to around one-third of the pure PE-LD films. An important result is that (effective) water vapor permeation coefficients calculated from results of sorption and measured by permeation experiments yielded similar values. It has been found that it is possible to describe the sorption and diffusion behavior of water by knowing the permeability coefficient and the sorption capacity of the film ( P eff . ≈ S eff . · D eff . ). The tensile stress changed only slightly (values between 10 and 14 N mm−2), while the tensile strain at break was reduced with higher nominal silica gel concentration from 318 length-% (pure PE-LD film) to 5 length-% (PE-LD with 0.6 g dispersed silica gel per 1 g film).
In-Lens Band-Pass Filter for Secondary Electrons in Ultrahigh Resolution SEM
Authors: Konvalina Ivo , Mika Filip , Krátký Stanislav , Materna Mikmeková Eliška , Müllerová Ilona
Published: July 2019

Scanning electron microscopes come equipped with different types of detectors for the collection of signal electrons emitted from samples. In-lens detection systems mostly consist of several auxiliary electrodes that help electrons to travel in a direction towards the detector. This paper aims to show that a through-the-lens detector in a commercial electron microscope Magellan 400 FEG can, under specific conditions, work as an energy band-pass filter of secondary electrons that are excited by the primary beam electrons. The band-pass filter properties verify extensive simulations of secondary and backscattered electrons in a precision 3D model of a microscope. A unique test sample demonstrates the effects of the band-pass filter on final image and contrast with chromium and silver stripes on a silicon substrate, manufactured by a combination of e-beam lithography, wet etching, and lift-off technique. The ray tracing of signal electrons in a detector model predicate that the through-the-lens detector works as a band-pass filter of the secondary electrons with an energy window of about 3 eV. By moving the energy window along the secondary electron energy spectrum curve of the analyzed material, we select the energy of the secondary electrons to be detected. Energy filtration brings a change in contrast in the image as well as displaying details that are not otherwise visible.
A Fast Derivative-Free Iteration Scheme for Nonlinear Systems and Integral Equations
Authors: Rostami Mozafar , Lotfi Taher , Brahmand Ali
Published: July 2019

Derivative-free schemes are a class of competitive methods since they are one remedy in cases at which the computation of the Jacobian or higher order derivatives of multi-dimensional functions is difficult. This article studies a variant of Steffensen’s method with memory for tackling a nonlinear system of equations, to not only be independent of the Jacobian calculation but also to improve the computational efficiency. The analytical parts of the work are supported by several tests, including an application in mixed integral equations.
Some New Observations on Geraghty and Ćirić Type Results in b-Metric Spaces
Authors: Mlaiki Nabil , Dedovic Neboǰša , Aydi Hassen , Gardašević-Filipović Milanka , Bin-Mohsin Bandar , Radenović Stojan
Published: July 2019

We discuss recent fixed point results in b-metric spaces given by Pant and Panicker (2016). Our results are with shorter proofs. In addition, for ε ∈ ( 1 , 3 ] , our results are genuine generalizations of ones from Pant and Panicker.
Properties of Fluctuating States in Loop Quantum Cosmology
Authors: Bojowald Martin
Published: July 2019

In loop quantum cosmology, the values of volume fluctuations and correlations determine whether the dynamics of an evolving state exhibits a bounce. Of particular interest are states that are supported only on either the positive or the negative part of the spectrum of the Hamiltonian that generates this evolution. It is shown here that the restricted support on the spectrum does not significantly limit the possible values of volume fluctuations.
Synthesis of Nano-Paramagnetic Oleuropein to Induce KRAS Over-Expression: A New Mechanism to Inhibit AGS Cancer Cells
Authors: Barzegar Farhad , Zaefizadeh Mohammad , Yari Reza , Salehzadeh Ali
Published: July 2019

Background and objectives: Human gastric adenocarcinoma (AGS) is one of the most common malignant cancers worldwide. The present study aimed to transfer oleuropein into cancer cells using synthetic paramagnetic nanoparticles and study their effect on the AGS (ATCC® CRL1739™) cell line. Materials and Methods: Paramagnetic nano-oleuropein was synthesized using four-stage co-precipitation by developing NH-connected bridges and was evaluated by EDS, SEM and FTIR methods. Different concentrations of magnetic oleuropein (0, 0.15, 0.45, 1.37, 4.12, 12.35, 37.04, 111.11, 333.33, 1000 µg/mL) were used to treat the AGS cell line in a completely randomized design using a statistical framework with three replicates. The relative expression rate of miR-200 and KRAS oncogenes was evaluated using real-time PCR. The inhibition rate of the AGS cells was assessed using the MTT test at 24, 48 and 72 h intervals. Results: The results showed that there was a significant difference between the inhibition rates of magnetic nano-oleuropein at IC50-24h (23.6 µg/mL), IC50-48h (15.2 µg/mL) and IC50-72h (9.2 µg/mL). Real-time PCR indicated that the relative expression of KRAS and miR-200 genes was highest at IC50 at these intervals. Conclusions: Magnetic nano-oleuropein can be subjected to objective testing and clinical evaluations as a natural antioxidant to prevent and treat gastric adenocarcinoma.
The Influence of Warm Rolling on Microstructure and Deformation Behavior of High Manganese Steels
Authors: Haupt Marco , Müller Max , Haase Christian , Sevsek Simon , Brasche Frederike , Schwedt Alexander , Hirt Gerhard
Published: July 2019

In this work, a Fe-23Mn-0.3C-1Al high manganese twinning-induced plasticity (TWIP) steel is subjected to varying warm rolling procedures in order to increase the yield strength and maintain a notable ductility. A comprehensive material characterization allows for the understanding of the activated deformation mechanisms and their impact on the resulting microstructure, texture, and mechanical properties. The results show a significant enhancement of the yield strength compared to a fully recrystallized Fe-23Mn-0.3C-1Al steel. This behavior is mainly dominated by the change of the active deformation mechanisms during rolling. Deformation twinning is very pronounced at lower temperatures, whereas this mechanism is suppressed at 500 °C and a thickness reduction of up to 50%. The mechanical properties can be tailored by adjusting rolling temperature and thickness reduction to desired applications.
Aging Phenomena during In-Service Creep Exposure of Heat-Resistant Steels
Authors: Haidemenopoulos G. N. , Polychronopoulou K. , Zervaki A. D. , Kamoutsi H. , Alkhoori S. I. , Jaffar S. , Cho P. , Mavros H.
Published: July 2019

An investigation of aging phenomena during creep exposure has been conducted for HP-Nb cast reformer tubes for several exposure conditions. Aging was manifested by carbide precipitation, carbide coarsening, and carbide transformation. The transformation of primary M7C3 to the more stable M23C6 carbide takes place at high exposure temperature (910 °C and above). The primary MC carbides transform to the Ni-Nb silicide or G-phase during creep exposure. The presence of Ti in the steel prevented the transformation of MC carbides to the G-phase. Morphological changes like needle to globular transitions, rounding of carbide edges, and carbide coarsening take place during creep exposure. The room-temperature tensile elongation and ultimate tensile strength are significantly reduced during creep exposure. The above aging phenomena are precursors to creep damage.
Microfluidic and Micromachined/MEMS Devices for Separation, Discrimination and Detection of Airborne Particles for Pollution Monitoring
Authors: Poenar Daniel Puiu
Published: July 2019

Most of the microfluidics-related literature describes devices handling liquids, with only a small part dealing with gas-based applications, and a much smaller number of papers are devoted to the separation and/or detection of airborne inorganic particles. This review is dedicated to this rather less known field which has become increasingly important in the last years due to the growing attention devoted to pollution monitoring and air quality assessment. After a brief introduction summarizing the main particulate matter (PM) classes and the need for their study, the paper reviews miniaturized devices and/or systems for separation, detection and quantitative assessment of PM concentration in air with portable and easy-to-use platforms. The PM separation methods are described first, followed by the key detection methods, namely optical (scattering) and electrical. The most important miniaturized reported realizations are analyzed, with special attention given to microfluidic and micromachined or micro-electro-mechanical systems (MEMS) chip-based implementations due to their inherent capability of being integrated in lab-on-chip (LOC) type of smart microsystems with increased functionalities that can be portable and are easy to use. The operating principles and (when available) key performance parameters of such devices are presented and compared, also highlighting their advantages and disadvantages. Finally, the most relevant conclusions are discussed in the last section.
A New Approach to Decoupled Non-Resonant Polishing
Authors: Li Yucheng , Zhou Xiaoqin , Wang Guilian , Ma Peiqun , Wang Rongqi
Published: July 2019

Two-dimensional vibration-assisted polishing (2D-VAP) is a new polishing approach proposed in recent years, which is considered to be very suitable for the polishing of micro-optical parts and micro-structured surfaces. The advantages of the 2D-VAP approach are as follows: A very high relative velocity can be obtained between the workpiece and the polishing tool; the desired motion trajectory can be formed in one polishing cycle. However, there are still some problems to be solved in the 2D-VAP approach, mainly involving: The vibration frequency of the resonant excitation cannot be regulated, which makes it difficult to adapt to the processing demands of different materials; the theoretical model of removal function has been studied in few papers; and motion coupling occurs easily between the horizontal and vertical directions, which affects the trajectory synthesized at the polishing tool. In order to solve these problems, a new approach to decoupled non-resonant polishing is developed in this paper, and its effectiveness is investigated by the theoretical analysis and polishing experiments. Theoretical studies of removal function show that the vibration frequency, vibration amplitude and loading force are proportional to the removal depth. The comparison of experimental and modeling results of removal function show that they have good coherence, and the correctness of the theoretical model of removal function is verified. In addition, the stability experiments of removal function prove that the polishing approach has better stability and is beneficial to the convergence of workpiece surface.
Effects of Chestnut Tannin Extract, Vescalagin and Gallic Acid on the Dimethyl Acetals Profile and Microbial Community Composition in Rumen Liquor: An In Vitro Study
Authors: Mannelli Federica , Daghio Matteo , Alves Susana P. , Bessa Rui J. B. , Minieri Sara , Giovannetti Luciana , Conte Giuseppe , Mele Marcello , Messini Anna , Rapaccini Stefano , Viti Carlo , Buccioni Arianna
Published: July 2019

The addition of polyphenol extracts in ruminant diets is an effective strategy to modulate rumen microflora. The aim of this in vitro trial was to study the effects of chestnut tannin extract (CHT), vescalagin (VES) and gallic acid (GAL) on dietary fibre degradability and on the dimethyl acetals (DMA) profile and microbial community composition of rumen liquor. Four diets (basal diet; basal diet plus CHT; basal diet plus VES; basal diet plus GAL) were fermented for 24 h using ewe rumen liquor. At the end of the fermentation, the microbial communities were characterized by sequencing the 16S rRNA gene. The DMA profile was analyzed by gas chromatography. Chestnut tannin extract did not affect fibre degradability, whereas VES and GAL showed a detrimental effect. The presence of CHT, VES and GAL influenced the concentration of several DMA (i.e., 12:0, 13:0, 14:0, 15:0, 18:0 and 18:1 trans-11), whereas the composition of the microbial community was marginally affected. The inclusion of CHT led to the enrichment of the genera Anaerovibrio, Bibersteinia, Escherichia/Shigella, Pseudobutyrivibrio and Streptococcus. The results of this study support the hypothesis that the activity of CHT is due to the synergistic effect of all components rather than the property of a single component.