bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from KRAS Activation in Gastric Adenocarcinoma Stimulates Epithelial-to-Mesenchymal Transition to Cancer Stem–Like Cells and Promotes Metastasis
Authors: Yoon Changhwan , Till Jacob , Cho Soo-Jeong , Chang Kevin K. , Lin Jian-xian , Huang Chang-ming , Ryeom Sandra , Yoon Sam S.
Published: April 2023

Abstract
Our previous work showed that in a mouse model of gastric adenocarcinoma with loss of p53 and Cdh1 that adding oncogenic Kras (a.k.a. Tcon mice) accelerates tumorigenesis and metastasis. Here, we sought to examine KRAS activation in epithelial-to-mesenchymal transition (EMT) and generation of cancer stem–like cells (CSC). Transduction of nontransformed HFE-145 gastric epithelial cells with oncogenic KRASG12V significantly decreased expression of the epithelial marker E-cadherin, increased expression of the mesenchymal marker vimentin and the EMT transcription factor Slug, and increased migration and invasion by 15- to 17-fold. KRASG12V also increased expression of self-renewal proteins such as Sox2 and increased spheroid formation by 2.6-fold. In tumor-derived organoids from Tcon mice, Kras knockdown decreased spheroid formation, expression of EMT-related proteins, migration, and invasion; similar effects, as well as reversal of chemoresistance, were observed following KRAS knockdown or MEK inhibition in patient tumor-derived gastric adenocarcinoma cell lines (AGS and KATOIII). KRAS inhibition in gastric adenocarcinoma spheroid cells led to reduced AGS flank xenograft growth, loss of the infiltrative tumor border, fewer lung metastases, and increased survival. In a tissue microarray of human gastric adenocarcinomas from 115 patients, high tumor levels of CD44 (a marker of CSCs) and KRAS activation were independent predictors of worse overall survival. In conclusion, KRAS activation in gastric adenocarcinoma cells stimulates EMT and transition to CSCs, thus promoting metastasis.
Implications:
This study provides rationale for examining inhibitors of KRAS to block metastasis and reverse chemotherapy resistance in gastric adenocarcinoma patients.
Table S1 from Risk Prediction of Cervical Cancer and Precancers by Type-Specific Human Papillomavirus: Evidence from a Population-Based Cohort Study in China
Authors: Dong Li , Hu Shang-Ying , Zhang Qian , Feng Rui-Mei , Zhang Li , Zhao Xue-Lian , Zhang Xun , Qiao You-Lin , Zhao Fang-Hui
Published: April 2023

Cumulative risk of CIN2+ and 95% confidence interval after one positive test of type-specific HPV.
Supplementary Figure 1 from A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women
Authors: Jiao Li , Maity Suman , Coarfa Cristian , Rajapakshe Kimal , Chen Liang , Jin Feng , Putluri Vasanta , Tinker Lesley F. , Mo Qianxing , Chen Fengju , Sen Subrata , Sangi-Hyghpeykar Haleh , El-Serag Hashem B. , Putluri Nagireddy
Published: April 2023

Supplemental figure 1
Supplementary tables from The Effects of Physical Activity and Body Fat Mass on Colorectal Polyp Recurrence in Patients with Previous Colorectal Cancer
Authors: Park Jihye , Kim Jae Hyun , Lee Hyun Jung , Park Soo Jung , Hong Sung Pil , Cheon Jae Hee , Kim Won Ho , Park Ji Soo , Jeon Justin Y. , Kim Tae Il
Published: April 2023

Supplementary table 1. Comparison of total number and interval of follow-up colonoscopies between the sedentary and active exercise group Supplementary table 2. Advanced adenoma recurrence rate according to exercise amount Supplementary table 3. Subgroup analysis of polyp recurrence rate according to exercise amount and body fat mass
Supplemental Figure 2 from The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4′-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth
Authors: Lim Tae-Gyu , Lee Sung-Young , Duan Zhaoheng , Lee Mee-Hyun , Chen Hanyong , Liu Fangfang , Liu Kangdong , Jung Sung Keun , Kim Dong Joon , Bode Ann M. , Lee Ki Won , Dong Zigang
Published: April 2023

Pin1 is overexpressed in esophageal cancer cells. The protein expression level of Pin1 was compared between normal (HaCaT) cells and esophageal cancer cells (KYSE 30, 450 and 510). The same amount of protein was analyzed by Western blot as described in Materials and Methods.
Supplementary Figures S1 - S4 from Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma
Authors: Kantrowitz Jacob , Sinjab Ansam , Xu Li , McDowell Tina L. , Sivakumar Smruthy , Lang Wenhua , Nunomura-Nakamura Sayuri , Fukuoka Junya , Nemer Georges , Darwiche Nadine , Chami Hassan , Tfayli Arafat , Wistuba Ignacio I. , Scheet Paul , Fujimoto Junya , Spira Avrum E. , Kadara Humam
Published: April 2023

S1. Lung tumor development in NNK-exposed Gprc5a-/- mice. S2. Evolutionarily conserved patterns of tobacco-carcinogen mediated gene expression in murine and human airway epithelia. S3. Early and persistent changes in mouse airway gene expression in vivo following tobacco carcinogen exposure and during lung oncogenesis. S4. Gene profiles downregulated in the mouse normal-appearing airway field of injury are overall suppressed in lung tumors relative to adjacent normal lung.
Supplementary Tables from Community-Based Pilot Study of a Screening Program for Gastric Cancer in a Chinese Population
Authors: Ji Lin , Liu Zengchao , Zhou Bin , Cai Ying , An Fangmei , Wang Lei , Lv Zhifa , Xia Min , Yang Jianbo , Yuan Jianfen , Wang Hui , Zhou Zhiyi , Yang Shudong , Hu Lei , Zhan Qiang
Published: April 2023

Supplementary Tables
Supplementary Table S1-S7 from Transcriptome Analysis of WHV/c-myc Transgenic Mice Implicates Cytochrome P450 Enzyme 17A1 as a Promising Biomarker for Hepatocellular Carcinoma
Authors: Wang Feng , Huang Jian , Zhu Zhu , Ma Xiao , Cao Li , Zhang Yongzhi , Chen Wei , Dong Yang
Published: April 2023

Supplementary Table S1, Clinical Characteristics of the Samples under Study. Supplementary Table S2, Expression of CYP17A1 in HCC (T) and Matched Non-Tumor (N) Tissues. Supplementary Table S3, Analysis of CYP17A1 Expression with Clinico-Pathological Parameters. Supplementary Table S4, The Diagnostic Values of CYP17A1 and AFP in Patients with HCC (n=776) versus Healthy Controls (n=366). Supplementary Table S5, The Diagnostic Values of CYP17A1 and AFP in Patients with Early HCC (Stages I-II, n=305) versus Healthy Controls (n=366). Supplementary Table S6, The Diagnostic Values of CYP17A1 and AFP in Patients with HCC (n=776) versus Non-HCC Subjects (HBV and Cirrhosis,n=307). Supplementary Table S7, The Diagnostic Values of CYP17A1 and AFP in Patients with Early HCC (Stages I-II, n=305) versus Non-HCC Subjects (HBV and Cirrhosis, n=307).
Supplementary figures from Cost Effectiveness of Lung Cancer Screening With Low-Dose CT in Heavy Smokers in China
Authors: Yuan Jingmin , Sun Yan , Wang Ke , Wang Zhiyi , Li Duo , Fan Meng , Bu Xiang , Chen Mingwei , Ren Hui
Published: April 2023

This file contains two supplementary figures of this article. Figure S1 shows the results of the probabilistic analyses as a cost-effectiveness scatter plot and Figure S2 shows the probability of cost-effectiveness of different screening scenarios.
Table S1, Table S2, Table S3 from Comparison of Different HPV-based Strategies and Cytology in Routine Cervical Cancer Screening Programme in China: A Population-based Study
Authors: Wang Shi , Li Ling , Yang Jie , Han Na , Bao Heling , Wang Hai-Jun
Published: April 2023

Table S1 shows the prevalence of screening abnormalities by age group. Table S2 shows the detection of CIN2+ and CIN3+ among women with abnormal screening results by age group. Table S3 provides the sensitivity analysis for performance of different screening strategies.
supplemental Figure 3 from Unconjugated Bilirubin Is a Novel Prognostic Biomarker for Nasopharyngeal Carcinoma and Inhibits Its Metastasis via Antioxidation Activity
Authors: Deng Cheng-Cheng , Xu Miao , Li Jing , Luo Xiao-Lin , Zhu Yu-Jia , Jiang Rou , Zhang Meng-Xia , Lei Jin-Ju , Lian Yi-Fan , Zou Xiong , You Rui , Chen Li-Zhen , Feng Qi-Sheng , Bei Jin-Xin , Chen Ming-Yuan , Zeng Yi-Xin
Published: April 2023

Supplemental Figure 3.Intraperitoneal injection of UCB increase serum UCB levels in nude mice.
supplemental Figure 1 from Unconjugated Bilirubin Is a Novel Prognostic Biomarker for Nasopharyngeal Carcinoma and Inhibits Its Metastasis via Antioxidation Activity
Authors: Deng Cheng-Cheng , Xu Miao , Li Jing , Luo Xiao-Lin , Zhu Yu-Jia , Jiang Rou , Zhang Meng-Xia , Lei Jin-Ju , Lian Yi-Fan , Zou Xiong , You Rui , Chen Li-Zhen , Feng Qi-Sheng , Bei Jin-Xin , Chen Ming-Yuan , Zeng Yi-Xin
Published: April 2023

Supplemental Figure 1.Receiver operating characteristic (ROC) curves of serum UCB levels.
Supplementary Figure from Prediction Models for Gastric Cancer Risk in the General Population: A Systematic Review
Authors: Gu Jianhua , Chen Ru , Wang Shao-Ming , Li Minjuan , Fan Zhiyuan , Li Xinqing , Zhou Jiachen , Sun Kexin , Wei Wenqiang
Published: April 2023

Supplementary Figure from Prediction Models for Gastric Cancer Risk in the General Population: A Systematic Review
Figure S6 from Chemoprevention of Preclinical Breast and Lung Cancer with the Bromodomain Inhibitor I-BET 762
Authors: Zhang Di , Leal Ana S. , Carapellucci Sarah , Zydeck Kayla , Sporn Michael B. , Liby Karen T.
Published: April 2023

Suppl Fig 6: Immunohistochemistry quantitation.
Supplementary Tables and Figure from “Rescue” of Nonparticipants in Colorectal Cancer Screening: A Randomized Controlled Trial of Three Noninvasive Test Options
Authors: Young Graeme Paul , Chen Gang , Wilson Carlene J. , McGrane Ellen , Hughes-Barton Donna Lee-Ann , Flight Ingrid Helen K. , Symonds Erin Leigh
Published: April 2023

Supplementary Tables 1 and 2, and Supplementary Figure 1
Supplementary tables from Dietary Intake of Branched-Chain Amino Acids and Risk of Colorectal Cancer
Authors: Katagiri Ryoko , Song Mingyang , Zhang Xuehong , Lee Dong Hoon , Tabung Fred K. , Fuchs Charles S. , Meyerhardt Jeffrey A. , Nishihara Reiko , Chan Andrew T. , Joshi Amit D. , Iwasaki Motoki , Ogino Shuji , Willett Walter C. , Giovannucci Edward , Wu Kana
Published: April 2023

supplemental table
Supplementary Table 1 & 2 from Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma
Authors: Monteiro de Oliveira Novaes Jose A. , Hirz Taghreed , Guijarro Irene , Nilsson Monique , Pisegna Marlese A. , Poteete Alissa , Barsoumian Hampartsoum B. , Fradette Jared J. , Chen Limo N. , Gibbons Don L. , Tian Xiangjun , Wang Jing , Myers Jeffrey N. , McArthur Mark J. , Bell Diana , William William N. , Heymach John V.
Published: April 2023

Table 1: Pathology classification criteria. Table 2: Flow cytometry antibodies
Supplemental Figure 2 from Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis
Authors: Jiang Guosong , Wu Amy D. , Huang Chao , Gu Jiayan , Zhang Liping , Huang Haishan , Liao Xin , Li Jingxia , Zhang Dongyun , Zeng Xingruo , Jin Honglei , Huang Haojie , Huang Chuanshu
Published: April 2023

FOXO1 stably knockout transfectants, including UMUC3 (KO FOXO1) (A) and T24T (KO FOXO1) (B), as well as Vector control transfectants were used for determination of their cell migration and invasion in presence of either vehicle or the indicated concentration of ISO treatment for 24 hours.
Supplementary Figure 1 from Methylseleninic Acid Superactivates p53-Senescence Cancer Progression Barrier in Prostate Lesions of Pten-Knockout Mouse
Authors: Wang Lei , Guo Xiaolan , Wang Ji , Jiang Cheng , Bosland Maarten C. , Lü Junxuan , Deng Yibin
Published: April 2023

MSeA inhibits tumor growth in Pten-deficiency-driven prostate tumorigenesis without affecting body weight in vivo.
Supplementary Figures S1 - S8 from Biallelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
Authors: Mehra Rohit , Vats Pankaj , Cieslik Marcin , Cao Xuhong , Su Fengyun , Shukla Sudhanshu , Udager Aaron M. , Wang Rui , Pan Jincheng , Kasaian Katayoon , Lonigro Robert , Siddiqui Javed , Premkumar Kumpati , Palapattu Ganesh , Weizer Alon , Hafez Khaled S. , Wolf J. Stuart , Sangoi Ankur R. , Trpkov Kiril , Osunkoya Adeboye O. , Zhou Ming , Giannico Giovanna , McKenney Jesse K. , Dhanasekaran Saravana M. , Chinnaiyan Arul M.
Published: April 2023

Supplementary Figures S1 - S8. Supplementary Figure S1. Intra-tumor mutational heterogeneity in MTSCC. Supplementary Figure S2. Copy number variation and Hippo pathway mutation in the MTSCC validation cohort and the TCGA KIRP outlier samples. Supplementary Figure S3. MTSCC Gene Expression Analyses. Supplementary Figure S4. PTPN14 function and Hippo pathway signature in kidney. Supplementary Figure S5. Gene set enrichment analysis. Supplementary Figure S6. HNF genes expression in normal human tissues, MTSCC and TCGA kidney cancer RNA-seq data. Supplementary Figure S7. Summary of YAP1 immunohistochemistry. Supplementary Figure S8. Gene expression correlation between MTSCC and nephron sections.
Figs S1-S10 from Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms
Authors: Yang Annan , Herter-Sprie Grit , Zhang Haikuo , Lin Elaine Y. , Biancur Douglas , Wang Xiaoxu , Deng Jiehui , Hai Josephine , Yang Shenghong , Wong Kwok-Kin , Kimmelman Alec C.
Published: April 2023

Supplemental Figures
Supplementary Table S5 from CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade
Authors: Chen Limo , Diao Lixia , Yang Yongbin , Yi Xiaohui , Rodriguez B. Leticia , Li Yanli , Villalobos Pamela A. , Cascone Tina , Liu Xi , Tan Lin , Lorenzi Philip L. , Huang Anfei , Zhao Qiang , Peng Di , Fradette Jared J. , Peng David H. , Ungewiss Christin , Roybal Jonathon , Tong Pan , Oba Junna , Skoulidis Ferdinandos , Peng Weiyi , Carter Brett W. , Gay Carl M. , Fan Youhong , Class Caleb A. , Zhu Jingfen , Rodriguez-Canales Jaime , Kawakami Masanori , Byers Lauren Averett , Woodman Scott E. , Papadimitrakopoulou Vassiliki A. , Dmitrovsky Ethan , Wang Jing , Ullrich Stephen E. , Wistuba Ignacio I. , Heymach John V. , Qin F. Xiao-Feng , Gibbons Don L.
Published: April 2023

The ranked gene list for GSEA.
Supplementary Table S1 from CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade
Authors: Chen Limo , Diao Lixia , Yang Yongbin , Yi Xiaohui , Rodriguez B. Leticia , Li Yanli , Villalobos Pamela A. , Cascone Tina , Liu Xi , Tan Lin , Lorenzi Philip L. , Huang Anfei , Zhao Qiang , Peng Di , Fradette Jared J. , Peng David H. , Ungewiss Christin , Roybal Jonathon , Tong Pan , Oba Junna , Skoulidis Ferdinandos , Peng Weiyi , Carter Brett W. , Gay Carl M. , Fan Youhong , Class Caleb A. , Zhu Jingfen , Rodriguez-Canales Jaime , Kawakami Masanori , Byers Lauren Averett , Woodman Scott E. , Papadimitrakopoulou Vassiliki A. , Dmitrovsky Ethan , Wang Jing , Ullrich Stephen E. , Wistuba Ignacio I. , Heymach John V. , Qin F. Xiao-Feng , Gibbons Don L.
Published: April 2023

Genes differentially expressed between IgG control and anti-PD-L1 treatment.
Supplementary Figure S2 from NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer
Authors: Heining Christoph , Horak Peter , Uhrig Sebastian , Codo Paula L. , Klink Barbara , Hutter Barbara , Fröhlich Martina , Bonekamp David , Richter Daniela , Steiger Katja , Penzel Roland , Endris Volker , Ehrenberg Karl Roland , Frank Stephanie , Kleinheinz Kortine , Toprak Umut H. , Schlesner Matthias , Mandal Ranadip , Schulz Lothar , Lambertz Helmut , Fetscher Sebastian , Bitzer Michael , Malek Nisar P. , Horger Marius , Giese Nathalia A. , Strobel Oliver , Hackert Thilo , Springfeld Christoph , Feuerbach Lars , Bergmann Frank , Schröck Evelin , von Kalle Christof , Weichert Wilko , Scholl Claudia , Ball Claudia R. , Stenzinger Albrecht , Brors Benedikt , Fröhling Stefan , Glimm Hanno
Published: April 2023

Supplementary Figure S2 shows experimental data demonstrating the proliferative capacity of the ATP1B1-NRG1 fusion.
Supplementary Tables from MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors
Authors: Sakthianandeswaren Anuratha , Parsons Marie J. , Mouradov Dmitri , MacKinnon Ruth N. , Catimel Bruno , Liu Sheng , Palmieri Michelle , Love Christopher , Jorissen Robert N. , Li Shan , Whitehead Lachlan , Putoczki Tracy L. , Preaudet Adele , Tsui Cary , Nowell Cameron J. , Ward Robyn L. , Hawkins Nicholas J. , Desai Jayesh , Gibbs Peter , Ernst Matthias , Street Ian , Buchert Michael , Sieber Oliver M.
Published: April 2023

Supplementary Tables 1-11 includes GISTIC results, clinical characteristics, details on cell lines and MACROD2 deletions, pathogenicity predictions, metaphase chromosomes anomalies, multivariate analyses and primer sequences.
Figure S2 from Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis
Authors: Ecker Brett L. , Kaur Amanpreet , Douglass Stephen M. , Webster Marie R. , Almeida Filipe V. , Marino Gloria E. , Sinnamon Andrew J. , Neuwirth Madalyn G. , Alicea Gretchen M. , Ndoye Abibatou , Fane Mitchell , Xu Xiaowei , Sim Myung Shin , Deutsch Gary B. , Faries Mark B. , Karakousis Giorgos C. , Weeraratna Ashani T.
Published: April 2023

Supplementary Figure 2
Figure S3 from Recurrent Tumor Cell–Intrinsic and –Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation
Authors: Song Chunying , Piva Marco , Sun Lu , Hong Aayoung , Moriceau Gatien , Kong Xiangju , Zhang Hong , Lomeli Shirley , Qian Jin , Yu Clarissa C. , Damoiseaux Robert , Kelley Mark C. , Dahlman Kimberley B. , Scumpia Philip O. , Sosman Jeffrey A. , Johnson Douglas B. , Ribas Antoni , Hugo Willy , Lo Roger S.
Published: April 2023

Figure S3
Supp. Table S2 from Genetic Mechanisms of Immune Evasion in Colorectal Cancer
Authors: Grasso Catherine S. , Giannakis Marios , Wells Daniel K. , Hamada Tsuyoshi , Mu Xinmeng Jasmine , Quist Michael , Nowak Jonathan A. , Nishihara Reiko , Qian Zhi Rong , Inamura Kentaro , Morikawa Teppei , Nosho Katsuhiko , Abril-Rodriguez Gabriel , Connolly Charles , Escuin-Ordinas Helena , Geybels Milan S. , Grady William M. , Hsu Li , Hu-Lieskovan Siwen , Huyghe Jeroen R. , Kim Yeon Joo , Krystofinski Paige , Leiserson Mark D.M. , Montoya Dennis J. , Nadel Brian B. , Pellegrini Matteo , Pritchard Colin C. , Puig-Saus Cristina , Quist Elleanor H. , Raphael Ben J. , Salipante Stephen J. , Shin Daniel Sanghoon , Shinbrot Eve , Shirts Brian , Shukla Sachet , Stanford Janet L. , Sun Wei , Tsoi Jennifer , Upfill-Brown Alexander , Wheeler David A. , Wu Catherine J. , Yu Ming , Zaidi Syed H. , Zaretsky Jesse M. , Gabriel Stacey B. , Lander Eric S. , Garraway Levi A. , Hudson Thomas J. , Fuchs Charles S. , Ribas Antoni , Ogino Shuji , Peters Ulrike
Published: April 2023

Supplementary Table S2: Somatic mutations
Supp. Figures and Legends from Genetic Mechanisms of Immune Evasion in Colorectal Cancer
Authors: Grasso Catherine S. , Giannakis Marios , Wells Daniel K. , Hamada Tsuyoshi , Mu Xinmeng Jasmine , Quist Michael , Nowak Jonathan A. , Nishihara Reiko , Qian Zhi Rong , Inamura Kentaro , Morikawa Teppei , Nosho Katsuhiko , Abril-Rodriguez Gabriel , Connolly Charles , Escuin-Ordinas Helena , Geybels Milan S. , Grady William M. , Hsu Li , Hu-Lieskovan Siwen , Huyghe Jeroen R. , Kim Yeon Joo , Krystofinski Paige , Leiserson Mark D.M. , Montoya Dennis J. , Nadel Brian B. , Pellegrini Matteo , Pritchard Colin C. , Puig-Saus Cristina , Quist Elleanor H. , Raphael Ben J. , Salipante Stephen J. , Shin Daniel Sanghoon , Shinbrot Eve , Shirts Brian , Shukla Sachet , Stanford Janet L. , Sun Wei , Tsoi Jennifer , Upfill-Brown Alexander , Wheeler David A. , Wu Catherine J. , Yu Ming , Zaidi Syed H. , Zaretsky Jesse M. , Gabriel Stacey B. , Lander Eric S. , Garraway Levi A. , Hudson Thomas J. , Fuchs Charles S. , Ribas Antoni , Ogino Shuji , Peters Ulrike
Published: April 2023

Supplementary Figures S1-S12 (with legends)
Figure S5 from Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
Authors: To Ciric , Jang Jaebong , Chen Ting , Park Eunyoung , Mushajiang Mierzhati , De Clercq Dries J.H. , Xu Man , Wang Stephen , Cameron Michael D. , Heppner David E. , Shin Bo Hee , Gero Thomas W. , Yang Annan , Dahlberg Suzanne E. , Wong Kwok-Kin , Eck Michael J. , Gray Nathanael S. , Jänne Pasi A.
Published: April 2023

The combination treatment of JBJ-04-125-02 and osimertinib do not result in any toxicity issues associated with weight loss but osimertinib at clinically relevant dose (25 mg/kg) is too potent to exhibit additive effect when combined with JBJ-04-125-02.
Supplemental Figures and Table from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
Authors: Chen Zhiguo , Mo Juan , Brosseau Jean-Philippe , Shipman Tracey , Wang Yong , Liao Chung-Ping , Cooper Jonathan M. , Allaway Robert J. , Gosline Sara J.C. , Guinney Justin , Carroll Thomas J. , Le Lu Q.
Published: April 2023

Supplemental Figure 1 shows the immunohistochemistry for nerve fibers in cNF. Supplemental Figure 2 shows the role of NF1 heterozygosity in neurofibroma development. Supplemental Figure 3 shows the effect of male Vs female on plexiform neurofibroma development. Supplemental Table 1 lists the genotype and phenotype of H7;Nf1mut and control mice.
Supplementary Figures S1-S20 from E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer
Authors: Bajrami Ilirjana , Marlow Rebecca , van de Ven Marieke , Brough Rachel , Pemberton Helen N. , Frankum Jessica , Song Feifei , Rafiq Rumana , Konde Asha , Krastev Dragomir B. , Menon Malini , Campbell James , Gulati Aditi , Kumar Rahul , Pettitt Stephen J. , Gurden Mark D. , Cardenosa Marta Llorca , Chong Irene , Gazinska Patrycja , Wallberg Fredrik , Sawyer Elinor J. , Martin Lesley-Ann , Dowsett Mitch , Linardopoulos Spiros , Natrajan Rachael , Ryan Colm J. , Derksen Patrick W.B. , Jonkers Jos , Tutt Andrew N.J. , Ashworth Alan , Lord Christopher J.
Published: April 2023

Supplementary Figures
Figure S2 from ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells
Authors: Jimenez-Pascual Ana , Hale James S. , Kordowski Anja , Pugh Jamie , Silver Daniel J. , Bayik Defne , Roversi Gustavo , Alban Tyler J. , Rao Shilpa , Chen Rui , McIntyre Thomas M. , Colombo Giorgio , Taraboletti Giulia , Holmberg Karl O. , Forsberg-Nilsson Karin , Lathia Justin D. , Siebzehnrubl Florian A.
Published: April 2023

Supplementary Figure S2
Supplementary Table S3 (xlsx) from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers
Authors: Klotz Remi , Thomas Amal , Teng Teng , Han Sung Min , Iriondo Oihana , Li Lin , Restrepo-Vassalli Sara , Wang Alan , Izadian Negeen , MacKay Matthew , Moon Byoung-San , Liu Kevin J. , Ganesan Sathish Kumar , Lee Grace , Kang Diane S. , Walmsley Charlotte S. , Pinto Christopher , Press Michael F. , Lu Wange , Lu Janice , Juric Dejan , Bardia Aditya , Hicks James , Salhia Bodour , Attenello Frank , Smith Andrew D. , Yu Min
Published: April 2023

List of unique genes upregulated in CTC-derived brain metastases
Supplementary Figures from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers
Authors: Klotz Remi , Thomas Amal , Teng Teng , Han Sung Min , Iriondo Oihana , Li Lin , Restrepo-Vassalli Sara , Wang Alan , Izadian Negeen , MacKay Matthew , Moon Byoung-San , Liu Kevin J. , Ganesan Sathish Kumar , Lee Grace , Kang Diane S. , Walmsley Charlotte S. , Pinto Christopher , Press Michael F. , Lu Wange , Lu Janice , Juric Dejan , Bardia Aditya , Hicks James , Salhia Bodour , Attenello Frank , Smith Andrew D. , Yu Min
Published: April 2023

File includes supplementary figures S1 to S5
Supplementary Data from Epigenetic Switch–Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer
Authors: Deblois Geneviève , Tonekaboni Seyed Ali Madani , Grillo Giacomo , Martinez Constanza , Kao Yunchi Ingrid , Tai Felicia , Ettayebi Ilias , Fortier Anne-Marie , Savage Paul , Fedor Alexandra N. , Liu Xiaojing , Guilhamon Paul , Lima-Fernandes Evelyne , Murison Alex , Kuasne Hellen , Ba-alawi Wail , Cescon David W. , Arrowsmith Cheryl H. , De Carvalho Daniel D. , Haibe-Kains Benjamin , Locasale Jason W. , Park Morag , Lupien Mathieu
Published: April 2023

Supplementary data, figures and table
TableS1.docx from Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade
Authors: Zhang Qu , Luo Jia , Wu Song , Si Han , Gao Chen , Xu Wenjing , Abdullah Shaad E. , Higgs Brandon W. , Dennis Phillip A. , van der Heijden Michiel S. , Segal Neil H. , Chaft Jamie E. , Hembrough Todd , Barrett J. Carl , Hellmann Matthew D.
Published: April 2023

Table S1
Supplementary Data from Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer
Authors: Liao Chengheng , Zhang Yang , Fan Cheng , Herring Laura E. , Liu Juan , Locasale Jason W. , Takada Mamoru , Zhou Jin , Zurlo Giada , Hu Lianxin , Simon Jeremy M. , Ptacek Travis S. , Andrianov Victor G. , Loza Einars , Peng Yan , Yang Huanghe , Perou Charles M. , Zhang Qing
Published: April 2023

Supplementary Data
Supplementary Figure S2 from Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer
Authors: Smyth Lillian M. , Piha-Paul Sarina A. , Won Helen H. , Schram Alison M. , Saura Cristina , Loi Sherene , Lu Janice , Shapiro Geoffrey I. , Juric Dejan , Mayer Ingrid A. , Arteaga Carlos L. , de la Fuente Macarena I. , Brufksy Adam M. , Spanggaard Iben , Mau-Sørensen Morten , Arnedos Monica , Moreno Victor , Boni Valentina , Sohn Joohyuk , Schwartzberg Lee S. , Gonzàlez-Farré Xavier , Cervantes Andrés , Bidard François-Clement , Gorelick Alexander N. , Lanman Richard B. , Nagy Rebecca J. , Ulaner Gary A. , Chandarlapaty Sarat , Jhaveri Komal , Gavrila Elena I. , Zimel Catherine , Selcuklu S. Duygu , Melcer Myra , Samoila Aliaksandra , Cai Yanyan , Scaltriti Maurizio , Mann Grace , Xu Feng , Eli Lisa D. , Dujka Melanie , Lalani Alshad S. , Bryce Richard , Baselga José , Taylor Barry S. , Solit David B. , Meric-Bernstam Funda , Hyman David M.
Published: April 2023

Overall sequencing CONSORT diagram. Flow diagram of study patients and analyzed biospecimens processed through and selected for central sequencing using MSK-IMPACT and Guardant360. cfDNA, cell-free DNA; FFPE, formalin-fixed paraffin-embedded; MSK-IMPACT, Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets; QC, quality control.
Supplementary Data from Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis
Authors: Zhang Yaqing , Lazarus Jenny , Steele Nina G. , Yan Wei , Lee Ho-Joon , Nwosu Zeribe C. , Halbrook Christopher J. , Menjivar Rosa E. , Kemp Samantha B. , Sirihorachai Veerin R. , Velez-Delgado Ashley , Donahue Katelyn , Carpenter Eileen S. , Brown Kristee L. , Irizarry-Negron Valerie , Nevison Anna C. , Vinta Alekya , Anderson Michelle A. , Crawford Howard C. , Lyssiotis Costas A. , Frankel Timothy L. , Bednar Filip , Pasca di Magliano Marina
Published: April 2023

Supplemental figure 3 with legend
Supplementary Figure 4 from The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells
Authors: Nechiporuk Tamilla , Kurtz Stephen E. , Nikolova Olga , Liu Tingting , Jones Courtney L. , D'Alessandro Angelo , Culp-Hill Rachel , d'Almeida Amanda , Joshi Sunil K. , Rosenberg Mara , Tognon Cristina E. , Danilov Alexey V. , Druker Brian J. , Chang Bill H. , McWeeney Shannon K , Tyner Jeffrey W.
Published: April 2023

Dose response curve analyses
Table S1 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Authors: Gu Zhimin , Liu Yuxuan , Cai Feng , Patrick McKenzie , Zmajkovic Jakub , Cao Hui , Zhang Yuannyu , Tasdogan Alpaslan , Chen Mingyi , Qi Le , Liu Xin , Li Kailong , Lyu Junhua , Dickerson Kathryn E. , Chen Weina , Ni Min , Merritt Matthew E. , Morrison Sean J. , Skoda Radek C. , DeBerardinis Ralph J. , Xu Jian
Published: April 2023

Table S1 shows the list of genomic datasets
Supplementary Table S6 from Extracellular ATP and CD39 Activate cAMP-Mediated Mitochondrial Stress Response to Promote Cytarabine Resistance in Acute Myeloid Leukemia
Authors: Aroua Nesrine , Boet Emeline , Ghisi Margherita , Nicolau-Travers Marie-Laure , Saland Estelle , Gwilliam Ryan , de Toni Fabienne , Hosseini Mohsen , Mouchel Pierre-Luc , Farge Thomas , Bosc Claudie , Stuani Lucille , Sabatier Marie , Mazed Fetta , Larrue Clément , Jarrou Latifa , Gandarillas Sarah , Bardotti Massimiliano , Picard Muriel , Syrykh Charlotte , Laurent Camille , Gotanègre Mathilde , Bonnefoy Nathalie , Bellvert Floriant , Portais Jean-Charles , Nicot Nathalie , Azuaje Francisco , Kaoma Tony , Joffre Carine , Tamburini Jérome , Récher Christian , Vergez François , Sarry Jean-Emmanuel
Published: April 2023

Table S6
Supplementary Table S5 from Extracellular ATP and CD39 Activate cAMP-Mediated Mitochondrial Stress Response to Promote Cytarabine Resistance in Acute Myeloid Leukemia
Authors: Aroua Nesrine , Boet Emeline , Ghisi Margherita , Nicolau-Travers Marie-Laure , Saland Estelle , Gwilliam Ryan , de Toni Fabienne , Hosseini Mohsen , Mouchel Pierre-Luc , Farge Thomas , Bosc Claudie , Stuani Lucille , Sabatier Marie , Mazed Fetta , Larrue Clément , Jarrou Latifa , Gandarillas Sarah , Bardotti Massimiliano , Picard Muriel , Syrykh Charlotte , Laurent Camille , Gotanègre Mathilde , Bonnefoy Nathalie , Bellvert Floriant , Portais Jean-Charles , Nicot Nathalie , Azuaje Francisco , Kaoma Tony , Joffre Carine , Tamburini Jérome , Récher Christian , Vergez François , Sarry Jean-Emmanuel
Published: April 2023

Table S5
Supplementary Table S3 from Extracellular ATP and CD39 Activate cAMP-Mediated Mitochondrial Stress Response to Promote Cytarabine Resistance in Acute Myeloid Leukemia
Authors: Aroua Nesrine , Boet Emeline , Ghisi Margherita , Nicolau-Travers Marie-Laure , Saland Estelle , Gwilliam Ryan , de Toni Fabienne , Hosseini Mohsen , Mouchel Pierre-Luc , Farge Thomas , Bosc Claudie , Stuani Lucille , Sabatier Marie , Mazed Fetta , Larrue Clément , Jarrou Latifa , Gandarillas Sarah , Bardotti Massimiliano , Picard Muriel , Syrykh Charlotte , Laurent Camille , Gotanègre Mathilde , Bonnefoy Nathalie , Bellvert Floriant , Portais Jean-Charles , Nicot Nathalie , Azuaje Francisco , Kaoma Tony , Joffre Carine , Tamburini Jérome , Récher Christian , Vergez François , Sarry Jean-Emmanuel
Published: April 2023

Table S3
Supplementary Table 7 from Clinical BRCA1/2 Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance
Authors: Pettitt Stephen J. , Frankum Jessica R. , Punta Marco , Lise Stefano , Alexander John , Chen Yi , Yap Timothy A. , Haider Syed , Tutt Andrew N.J. , Lord Christopher J.
Published: April 2023

Reversion neopeptide presentation scores
Supplementary Table 5 from Clinical BRCA1/2 Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance
Authors: Pettitt Stephen J. , Frankum Jessica R. , Punta Marco , Lise Stefano , Alexander John , Chen Yi , Yap Timothy A. , Haider Syed , Tutt Andrew N.J. , Lord Christopher J.
Published: April 2023

Incidence data
Supplementary Figures from Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast–Driven Nutritional Support and Immunosuppression
Authors: Francescone Ralph , Barbosa Vendramini-Costa Débora , Franco-Barraza Janusz , Wagner Jessica , Muir Alexander , Lau Allison N. , Gabitova Linara , Pazina Tatiana , Gupta Sapna , Luong Tiffany , Rollins Dustin , Malik Ruchi , Thapa Roshan J. , Restifo Diana , Zhou Yan , Cai Kathy Q. , Hensley Harvey H. , Tan Yinfei , Kruger Warren D. , Devarajan Karthik , Balachandran Siddharth , Klein-Szanto Andres J. , Wang Huamin , El-Deiry Wafik S. , Vander Heiden Matthew G. , Peri Suraj , Campbell Kerry S. , Astsaturov Igor , Cukierman Edna
Published: April 2023

18 supplementary figures and corresponding legends
Key Resources Table from Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast–Driven Nutritional Support and Immunosuppression
Authors: Francescone Ralph , Barbosa Vendramini-Costa Débora , Franco-Barraza Janusz , Wagner Jessica , Muir Alexander , Lau Allison N. , Gabitova Linara , Pazina Tatiana , Gupta Sapna , Luong Tiffany , Rollins Dustin , Malik Ruchi , Thapa Roshan J. , Restifo Diana , Zhou Yan , Cai Kathy Q. , Hensley Harvey H. , Tan Yinfei , Kruger Warren D. , Devarajan Karthik , Balachandran Siddharth , Klein-Szanto Andres J. , Wang Huamin , El-Deiry Wafik S. , Vander Heiden Matthew G. , Peri Suraj , Campbell Kerry S. , Astsaturov Igor , Cukierman Edna
Published: April 2023

Lists all key resources and reagents
Supplementary Methods from Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling
Authors: Gimple Ryan C. , Kidwell Reilly L. , Kim Leo J.Y. , Sun Tengqian , Gromovsky Anthony D. , Wu Qiulian , Wolf Megan , Lv Deguan , Bhargava Shruti , Jiang Li , Prager Briana C. , Wang Xiuxing , Ye Qing , Zhu Zhe , Zhang Guoxin , Dong Zhen , Zhao Linjie , Lee Derrick , Bi Junfeng , Sloan Andrew E. , Mischel Paul S. , Brown J. Mark , Cang Hu , Huan Tao , Mack Stephen C. , Xie Qi , Rich Jeremy N.
Published: April 2023

Supplementary Methods Section
Supplementary Methods 2 from Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling
Authors: Gimple Ryan C. , Kidwell Reilly L. , Kim Leo J.Y. , Sun Tengqian , Gromovsky Anthony D. , Wu Qiulian , Wolf Megan , Lv Deguan , Bhargava Shruti , Jiang Li , Prager Briana C. , Wang Xiuxing , Ye Qing , Zhu Zhe , Zhang Guoxin , Dong Zhen , Zhao Linjie , Lee Derrick , Bi Junfeng , Sloan Andrew E. , Mischel Paul S. , Brown J. Mark , Cang Hu , Huan Tao , Mack Stephen C. , Xie Qi , Rich Jeremy N.
Published: April 2023

Supplementary Methods 2
Table S3 from Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis
Authors: Taylor Justin , Sendino Maria , Gorelick Alexander N. , Pastore Alessandro , Chang Matthew T. , Penson Alexander V. , Gavrila Elena I. , Stewart Connor , Melnik Ella M. , Herrejon Chavez Florisela , Bitner Lillian , Yoshimi Akihide , Lee Stanley Chun-Wei , Inoue Daichi , Liu Bo , Zhang Xiao J. , Mato Anthony R. , Dogan Ahmet , Kharas Michael G. , Chen Yuhong , Wang Demin , Soni Rajesh K. , Hendrickson Ronald C. , Prieto Gorka , Rodriguez Jose A. , Taylor Barry S. , Abdel-Wahab Omar
Published: April 2023

Fold-change in abundance and statistical significance of proteins in XPO1E571K/WT versus XPO1WT NALM-6 cells detected by SILAC analysis of cytoplasmic fractions
Supplementary Figures from Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis
Authors: Taylor Justin , Sendino Maria , Gorelick Alexander N. , Pastore Alessandro , Chang Matthew T. , Penson Alexander V. , Gavrila Elena I. , Stewart Connor , Melnik Ella M. , Herrejon Chavez Florisela , Bitner Lillian , Yoshimi Akihide , Lee Stanley Chun-Wei , Inoue Daichi , Liu Bo , Zhang Xiao J. , Mato Anthony R. , Dogan Ahmet , Kharas Michael G. , Chen Yuhong , Wang Demin , Soni Rajesh K. , Hendrickson Ronald C. , Prieto Gorka , Rodriguez Jose A. , Taylor Barry S. , Abdel-Wahab Omar
Published: April 2023

Supplementary Figures S1-S12
Figure S9 from Discovery and Features of an Alkylating Signature in Colorectal Cancer
Authors: Gurjao Carino , Zhong Rong , Haruki Koichiro , Li Yvonne Y. , Spurr Liam F. , Lee-Six Henry , Reardon Brendan , Ugai Tomotaka , Zhang Xuehong , Cherniack Andrew D. , Song Mingyang , Van Allen Eliezer M. , Meyerhardt Jeffrey A. , Nowak Jonathan A. , Giovannucci Edward L. , Fuchs Charles S. , Wu Kana , Ogino Shuji , Giannakis Marios
Published: April 2023

Supplemental Figure 9: Lack of association of the alkylating signature with germline SNPs in FA and TLS genes The False Discovery Rate (FDR) adjusted p-value (y axis) for SNPs in each FA (A) and TLS (B) gene (x axis) colored by chromosome location. The blue horizontal line indicates the significance threshold of <0.1. FA: Fanconi Anemia, TLS: Translesion synthesis.
Figure S8 from Discovery and Features of an Alkylating Signature in Colorectal Cancer
Authors: Gurjao Carino , Zhong Rong , Haruki Koichiro , Li Yvonne Y. , Spurr Liam F. , Lee-Six Henry , Reardon Brendan , Ugai Tomotaka , Zhang Xuehong , Cherniack Andrew D. , Song Mingyang , Van Allen Eliezer M. , Meyerhardt Jeffrey A. , Nowak Jonathan A. , Giovannucci Edward L. , Fuchs Charles S. , Wu Kana , Ogino Shuji , Giannakis Marios
Published: April 2023

Supplemental Figure 8: Signature assignment after under sampling Under sampling simulations from 900 (NHS/HPFS sample size) to 540 (TCGA CRC sample size). For each signature (x axis) we count each type of closest signatures (y axis) deconvoluted after under sampling.
Figure S11 from Discovery and Features of an Alkylating Signature in Colorectal Cancer
Authors: Gurjao Carino , Zhong Rong , Haruki Koichiro , Li Yvonne Y. , Spurr Liam F. , Lee-Six Henry , Reardon Brendan , Ugai Tomotaka , Zhang Xuehong , Cherniack Andrew D. , Song Mingyang , Van Allen Eliezer M. , Meyerhardt Jeffrey A. , Nowak Jonathan A. , Giovannucci Edward L. , Fuchs Charles S. , Wu Kana , Ogino Shuji , Giannakis Marios
Published: April 2023

Supplemental Figure 11: Association of red meat intake with other CRC mutational processes Proportion of mutations assigned to alkylating damage segregated by overall red meat intake (top decile in grams per day versus the rest, as defined in the manuscript) for the other CRC mutational processes. The two-sided Mann-Whitney test p-value is indicated.
Supplementary Figure 4 from Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution
Authors: Venkatesan Subramanian , Angelova Mihaela , Puttick Clare , Zhai Haoran , Caswell Deborah R. , Lu Wei-Ting , Dietzen Michelle , Galanos Panagiotis , Evangelou Konstantinos , Bellelli Roberto , Lim Emilia L. , Watkins Thomas B.K. , Rowan Andrew , Teixeira Vitor H. , Zhao Yue , Chen Haiquan , Ngo Bryan , Zalmas Lykourgos-Panagiotis , Al Bakir Maise , Hobor Sebastijan , Grönroos Eva , Pennycuick Adam , Nigro Ersilia , Campbell Brittany B. , Brown William L. , Akarca Ayse U. , Marafioti Teresa , Wu Mary Y. , Howell Michael , Boulton Simon J. , Bertoli Cosetta , Fenton Tim R. , de Bruin Robertus A.M. , Maya-Mendoza Apolinar , Santoni-Rugiu Eric , Hynds Robert E. , Gorgoulis Vassilis G. , Jamal-Hanjani Mariam , McGranahan Nicholas , Harris Reuben S. , Janes Sam M. , Bartkova Jirina , Bakhoum Samuel F. , Bartek Jiri , Kanu Nnennaya , Swanton Charles
Published: April 2023

Correlation between APOBEC3 expression and different measures of CIN.
Table S1 from Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade
Authors: Gu Shengqing Stan , Zhang Wubing , Wang Xiaoqing , Jiang Peng , Traugh Nicole , Li Ziyi , Meyer Clifford , Stewig Blair , Xie Yingtian , Bu Xia , Manos Michael P. , Font-Tello Alba , Gjini Evisa , Lako Ana , Lim Klothilda , Conway Jake , Tewari Alok K. , Zeng Zexian , Sahu Avinash Das , Tokheim Collin , Weirather Jason L. , Fu Jingxin , Zhang Yi , Kroger Benjamin , Liang Jin Hua , Cejas Paloma , Freeman Gordon J. , Rodig Scott , Long Henry W. , Gewurz Benjamin E. , Hodi F. Stephen , Brown Myles , Liu X. Shirley
Published: April 2023

MAGeCK analysis of CRISPR screen results to identify the regulators of MHC-I/PD-L1
Figure S5 from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium
Authors: Pikman Yana , Tasian Sarah K. , Sulis Maria Luisa , Stevenson Kristen , Blonquist Traci M. , Apsel Winger Beth , Cooper Todd M. , Pauly Melinda , Maloney Kelly W. , Burke Michael J. , Brown Patrick A. , Gossai Nathan , McNeer Jennifer L. , Shukla Neerav N. , Cole Peter D. , Kahn Justine M. , Chen Jing , Barth Matthew J. , Magee Jeffrey A. , Gennarini Lisa , Adhav Asmani A. , Clinton Catherine M. , Ocasio-Martinez Nicole , Gotti Giacomo , Li Yuting , Lin Shan , Imamovic Alma , Tognon Cristina E. , Patel Tasleema , Faust Haley L. , Contreras Cristina F. , Cremer Anjali , Cortopassi Wilian A. , Garrido Ruiz Diego , Jacobson Matthew P. , Dharia Neekesh V. , Su Angela , Robichaud Amanda L. , Saur Conway Amy , Tarlock Katherine , Stieglitz Elliot , Place Andrew E. , Puissant Alexandre , Hunger Stephen P. , Kim Annette S. , Lindeman Neal I. , Gore Lia , Janeway Katherine A. , Silverman Lewis B. , Tyner Jeffrey W. , Harris Marian H. , Loh Mignon L. , Stegmaier Kimberly
Published: April 2023

combination of MEK inhibitor with venetoclax in primary patient samples and KOPN-8 cells.
Figure S3 from Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium
Authors: Pikman Yana , Tasian Sarah K. , Sulis Maria Luisa , Stevenson Kristen , Blonquist Traci M. , Apsel Winger Beth , Cooper Todd M. , Pauly Melinda , Maloney Kelly W. , Burke Michael J. , Brown Patrick A. , Gossai Nathan , McNeer Jennifer L. , Shukla Neerav N. , Cole Peter D. , Kahn Justine M. , Chen Jing , Barth Matthew J. , Magee Jeffrey A. , Gennarini Lisa , Adhav Asmani A. , Clinton Catherine M. , Ocasio-Martinez Nicole , Gotti Giacomo , Li Yuting , Lin Shan , Imamovic Alma , Tognon Cristina E. , Patel Tasleema , Faust Haley L. , Contreras Cristina F. , Cremer Anjali , Cortopassi Wilian A. , Garrido Ruiz Diego , Jacobson Matthew P. , Dharia Neekesh V. , Su Angela , Robichaud Amanda L. , Saur Conway Amy , Tarlock Katherine , Stieglitz Elliot , Place Andrew E. , Puissant Alexandre , Hunger Stephen P. , Kim Annette S. , Lindeman Neal I. , Gore Lia , Janeway Katherine A. , Silverman Lewis B. , Tyner Jeffrey W. , Harris Marian H. , Loh Mignon L. , Stegmaier Kimberly
Published: April 2023

Analysis of Beat AML data.
Supplementary Figure S10 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Authors: Pore Nabendu , Wu Song , Standifer Nathan , Jure-Kunkel Maria , de los Reyes Melissa , Shrestha Yashaswi , Halpin Rebecca , Rothstein Raymond , Mulgrew Kathy , Blackmore Stephen , Martin Philip , Meekin John , Griffin Matthew , Bisha Ina , Proia Theresa A. , Miragaia Ricardo J. , Herbst Ronald , Gupta Ashok , Abdullah Shaad E. , Raja Rajiv , Frigault Melanie M. , Barrett J. Carl , Dennis Phillip A. , Ascierto Maria Libera , Oberst Michael D.
Published: April 2023

Efficacy of TORC1/2, CXCR2, CSF1R inhibition or 1A8 Ly6G+ cell depletion plus combination CPI therapy in CT26 STK11 KO model. Survival of mice treated with the TORC1/2 inhibitor AZD2014 as monotherapy or in combination with anti-PD-L1 plus anti-CTLA-4 in (A) CT26 WT or (B) CT26 STK11 KO clone 26C16. (C) Percentage of Ly6G+ cells among CD45+ immune cells in tumor or spleen, as indicated, in mice engrafted with CT26 STK11 KO tumors and left untreated or treated with the anti-Ly6G mAb clone 1A8 twice on days 2 and 4 after cell implantation with tissue harvest on day 6. *p = 0.01; **p = 0.0003, two-tailed Student's t-test. (D) Survival of mice engrafted with the CT26 STK11 KO clone 26C16 treated with the Ly6G+ cell-depleting Ab clone 1A8 in combination with dual CPI therapy. Survival of mice engrafted with (E, F) CT26 WT or (G, H) CT26 STK11 KO clone 26C16 treated with the CSF1R inhibitor AZD6495 or the CXCR2 inhibitor AZD5069 alone or in combination with each other or anti-PD-L1 plus anti-CTLA-4 therapy as indicated.
Supplementary Figure 3 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation
Authors: Lo Yuan-Hung , Kolahi Kevin S. , Du Yuhong , Chang Chiung-Ying , Krokhotin Andrey , Nair Ajay , Sobba Walter D. , Karlsson Kasper , Jones Sunny J. , Longacre Teri A. , Mah Amanda T. , Tercan Bahar , Sockell Alexandra , Xu Hang , Seoane Jose A. , Chen Jin , Shmulevich Ilya , Weissman Jonathan S. , Curtis Christina , Califano Andrea , Fu Haian , Crabtree Gerald R. , Kuo Calvin J.
Published: April 2023

Supplementary Figure 3
Supplementary Figures from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy
Authors: Tang Yuting , Xu Qian , Hu Liang , Yan Xiaomei , Feng Xiaomin , Yokota Asumi , Wang Weinan , Zhan Di , Krishnamurthy Durga , Ochayon David E. , Wen Lijun , Huo Li , Zeng Huimin , Luo Yingwan , Huang L. Frank , Wunderlich Mark , Zhang Jiwang , Vivier Eric , Zhou Jianfeng , Waggoner Stephen N. , Huang Gang
Published: April 2023

Supplementary Figures
Supplementary Tables from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem
Authors: McLeod Clay , Gout Alexander M. , Zhou Xin , Thrasher Andrew , Rahbarinia Delaram , Brady Samuel W. , Macias Michael , Birch Kirby , Finkelstein David , Sunny Jobin , Mudunuri Rahul , Orr Brent A. , Treadway Madison , Davidson Bob , Ard Tracy K. , Chiao Arthur , Swistak Andrew , Wiggins Stephanie , Foy Scott , Wang Jian , Sioson Edgar , Wang Shuoguo , Michael J. Robert , Liu Yu , Ma Xiaotu , Patel Aman , Edmonson Michael N. , Wilkinson Mark R. , Frantz Andrew M. , Chang Ti-Cheng , Tian Liqing , Lei Shaohua , Islam S.M. Ashiqul , Meyer Christopher , Thangaraj Naina , Tater Pamella , Kandali Vijay , Ma Singer , Nguyen Tuan , Serang Omar , McGuire Irina , Robison Nedra , Gentry Darrell , Tang Xing , Palmer Lance E. , Wu Gang , Suh Ed , Tanner Leigh , McMurry James , Lear Matthew , Pappo Alberto S. , Wang Zhaoming , Wilson Carmen L. , Cheng Yong , Meshinchi Soheil , Alexandrov Ludmil B. , Weiss Mitchell J. , Armstrong Gregory T. , Robison Leslie L. , Yasui Yutaka , Nichols Kim E. , Ellison David W. , Bangur Chaitanya , Mullighan Charles G. , Baker Suzanne J. , Dyer Michael A. , Miller Geralyn , Newman Scott , Rusch Michael , Daly Richard , Perry Keith , Downing James R. , Zhang Jinghui
Published: April 2023

Excel file of Supplementary Tables
Table S1 from Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence
Authors: Duy Cihangir , Li Meng , Teater Matt , Meydan Cem , Garrett-Bakelman Francine E. , Lee Tak C. , Chin Christopher R. , Durmaz Ceyda , Kawabata Kimihito C. , Dhimolea Eugen , Mitsiades Constantine S. , Doehner Hartmut , D'Andrea Richard J. , Becker Michael W. , Paietta Elisabeth M. , Mason Christopher E. , Carroll Martin , Melnick Ari M.
Published: April 2023

Gene sets
Supplementary Figure S8 from MET Amplification Attenuates Lung Tumor Response to Immunotherapy by Inhibiting STING
Authors: Zhang Yong , Yang Qifan , Zeng Xiangyu , Wang Manxiang , Dong Shuang , Yang Bin , Tu Xinyi , Wei Ting , Xie Wenzhuan , Zhang Chao , Guo Qiang , Kloeber Jake A. , Cao Yueyu , Guo Guijie , Zhou Qin , Zhao Fei , Huang Jinzhou , Liu Li , Zhang Kai , Wang Mingwei , Yin Ping , Luo Kuntian , Deng Min , Kim Wootae , Hou Jing , Shi Yu , Zhu Qian , Chen Lifeng , Hu Sheng , Yue Junqiu , Pi Guoliang , Lou Zhenkun
Published: April 2023

UPF1 can be phosphorylated at tyrosine residues in a MET kinase-dependent manner
Supplemental Figure 6 from PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability
Authors: Pitarresi Jason R. , Norgard Robert J. , Chiarella Anna M. , Suzuki Kensuke , Bakir Basil , Sahu Varun , Li Jinyang , Zhao Jun , Marchand Benoît , Wengyn Maximilian D. , Hsieh Antony , Kim Il-Kyu , Zhang Amy , Sellin Karine , Lee Vivian , Takano Shigetsugu , Miyahara Yoji , Ohtsuka Masayuki , Maitra Anirban , Notta Faiyaz , Kremer Richard , Stanger Ben Z. , Rustgi Anil K.
Published: April 2023

Supplemental Figure 6
Supplementary Figure S2 from MET Amplification Attenuates Lung Tumor Response to Immunotherapy by Inhibiting STING
Authors: Zhang Yong , Yang Qifan , Zeng Xiangyu , Wang Manxiang , Dong Shuang , Yang Bin , Tu Xinyi , Wei Ting , Xie Wenzhuan , Zhang Chao , Guo Qiang , Kloeber Jake A. , Cao Yueyu , Guo Guijie , Zhou Qin , Zhao Fei , Huang Jinzhou , Liu Li , Zhang Kai , Wang Mingwei , Yin Ping , Luo Kuntian , Deng Min , Kim Wootae , Hou Jing , Shi Yu , Zhu Qian , Chen Lifeng , Hu Sheng , Yue Junqiu , Pi Guoliang , Lou Zhenkun
Published: April 2023

MET amplification is associated with poor response to ICB