bluuebunny/crossref_metadata_2025 huggingface dataset:
Primary Malignant Deciduoid Mesothelioma: A Challenging Diagnosis
Authors: Regragui Meriem , Guebessi Nisrine Bennani
Published: November 2018

Primary malignant deciduoid mesothelioma is a rare subtype of epithelioid mesothelioma that was first described in the peritoneum in young women without a history of asbestos exposure. It was thought to be a distinct clinicopathologic entity with ominous prognosis; recent studies have better characterized this entity. On morphology, primary malignant deciduoid mesothelioma is characterized by cytomorphologic features resembling decidualized tissue. Pleomorphism is variable. The immunoprofile is similar to other epithelioid mesotheliomas. The prognosis is the same as other epithelioid mesotheliomas and seems to depend on histological grade.
Teaching Genomic Pathology: Translating Team-Based Learning to a Virtual Environment Using Computer-Based Simulation
Authors: Haspel Richard L. , Ali Asma M. , Huang Grace C. , Smith Matt H. , Atkinson James B. , Chabot-Richards Devon S. , Elliott Robin M. , Kaul Karen L. , Powell Suzanne Z. , Rao Arundhati , Rinder Henry M. , Vanderbilt Chad M. , Wilcox Rebecca
Published: November 2018

Context.—

Developing skills related to use of computer-based tools is critical for practicing genomic pathology. However, given the relative novelty of genomics education, residency programs may lack faculty members with adequate expertise and/or time to implement training. A virtual team-based learning (TBL) environment would make genomic pathology education available to more trainees.

Objective.—

To translate an extensively implemented in-person TBL genomic pathology workshop into a virtual environment and to evaluate both knowledge and skill acquisition.

Design.—

Using a novel interactive simulation approach, online modules were developed translating aspects of the TBL experience into the virtual environment with a goal of acquisition of necessary computer-related skills. The modules were evaluated at 10 postgraduate pathology training programs using a pre-post test design with participants deidentified. A postmodule anonymous survey obtained participant feedback on module quality and efficacy.

Results.—

There were 147 trainees who received an email request to voluntarily participate in the study. Of these, 43 trainees completed the pretest and 15 (35%) subsequently completed the posttest. Mean overall scores were 45% on the pretest compared with 70% on the posttest (P < .001; effect size = 1.4). Posttest improvement of results was similar for questions testing acquisition of knowledge versus skills. Regarding the 19 participants who took the survey, 18 (95%) would recommend the modules to others and believed they met the stated objectives.

Conclusions.—

A simulation-based approach allows motivated pathology trainees to acquire computer-related skills for practicing genomic pathology. Future work can explore efficacy in a nonvoluntary setting and adaptation to different specialties, learners, and computer tools.
Data Set for the Reporting of Carcinomas of the Nasal Cavity and Paranasal Sinuses: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting
Authors: Franchi Alessandro , Bishop Justin A. , Coleman Hedley , Flucke Uta , Licitra Lisa F. , Pendás José Luis Llorente , Stelow Edward B. , Toner Mary , Weinreb Ilan , Wenig Bruce M. , Thompson Lester D. R.
Published: November 2018

The International Collaboration on Cancer Reporting was established to internationally unify and standardize the pathologic reporting of cancers based on collected evidence, as well as to allow systematic multi-institutional intercountry data collection to guide cancer care in the future. This data set has been developed by the collaborative efforts of an international multidisciplinary panel of experts involved in the care of patients with carcinomas of the nasal cavity and paranasal sinuses (sinonasal tract). The nasal cavity and paranasal sinuses (including frontal, sphenoid, ethmoid, and maxillary sinuses) comprise a very complex anatomic area of the head and neck, affected by a sometimes bewildering array of neoplasms. Management of malignancies in this anatomic region involves complex surgery because of the anatomic confines and close proximity to many vital structures. Given a multidisciplinary approach, the standardized reporting of the carcinomas that develop in this anatomic region include both required (core) and recommended (noncore) elements in pathology reporting in order to be able to identify critical prognostic factors, often requiring clinical and radiologic correlation. A summary of the International Collaboration on Cancer Reporting guidelines and clinically relevant elements, along with additional explanatory notes, are provided, based on evidentiary support from the literature, set in the context of practical application.
Management of a Ferry Construction Project Using a Production- Oriented Design Methodology
Authors: Mascaraque-Ramírez Carlos , Para-González Lorena , Marco-Jornet Paloma
Published: November 2018

In an increasingly globalized sector such as the naval construction sector, the search for reduction in execution terms and production costs becomes essential. With this aim, the vessel project should be analyzed globally and in conjunction with the installations in which it will be built. The present research includes a series of improvement proposals for the construction of a 78-m-long ferry, designed for the transport of 700 passengers and 590 lineal meters of cargo space. These improvements are focused on the standardization of equipment and components in the accommodation area and engine room, as well as in the general arrangement of these spaces, by orienting their design toward manufacturing. All this will lead to a series of results, which demonstrate that the correct application of these changes considerably reduces production time and, consequently, the costs associated with it. In parallel, this study analyzes the facilities of the shipyard, proposing changes in its workshops and identifying new business lines to improve the strategic situation of the organization.

1. Introduction

Historically, European shipyards have manufactured in their installations a great variety of ships, each one with a high component of technological innovation. The high quality of their products and their adaptability to custom orders from the ship owners have led the naval construction sector to be currently identified at an international level as a sector with highly differentiated products.

The impact that international competition has had in the last decades, and more recently the economic crisis and the file opening by the European Commission in relation to the old system of "tax lease" applied in Europe (Curtis 2014), reduced the level of new ships construction contracting in 2011. The published registers (LR-Lloyds-Fairplay 2015) about the new ship constructions places European manufacturers far from the construction volumes of Asian manufacturers in terms of compensated gross tonnage (CGT), which is a measure of the compensated gross arching related to the gross tonnage through a compensation coefficient for each ship type and size, which considers the construction complexity based on the manufacturing work hours needed.
The prospective association between the Five Factor personality model with health behaviors and health behavior clusters
Authors: Joyner Chelsea , Rhodes Ryan E. , Loprinzi Paul D.
Published: November 2018

To examine the prospective association of personality with individual behavior, multibehavior and clustered health behavior profiles. A prospective study design was employed. Two hundred young adults provided baseline data and 126 (mean age: 21.6 yrs) provide complete data for a 5-month follow-up assessment (63% response rate). Personality and health behaviors (and covariates) were assessed via validated questionnaires. A multibehavior index variable was created ranging from 0-5; two separate health behavior cluster indices were created, including high (4-5 behaviors) vs. low (2 or fewer) behavior adoption and an energy balance cluster (MVPA and diet). When examining MVPA as a continuous variable, the personality trait conscientiousness was prospectively associated with MVPA and a healthy diet. Extraversion was prospectively associated with high (vs. low) behavioral clustering (OR = 1.18; 95% CI: 1.00-1.40) and conscientiousness was prospectively associated with energy balance clustering (OR = 1.09; 95% CI: 1.01-1.17). Extraversion, conscientiousness, openness to experience, and agreeableness were associated with select health-related behaviors. Further, extraversion and conscientiousness were associated with health behavior clustering.
Positive variables in adult patients who are at different stages of a naturalistic psychotherapeutic treatment
Authors: Gongora Vanesa C.
Published: November 2018

This study aimed twofold: 1) to study some positive variables (three paths to well-being, life satisfaction, overall well-being and meaning of life) in adult patients who are at different stages of a naturalistic cognitive behavioral psychotherapeutic treatment and 2) to analyze their relationship with the progress during treatment, therapeutic alliance and adherence to treatment from the therapist´s perspective. The sample was composed of 85 outpatients who were in psychotherapeutic treatment. Patients completed the Three Pathways to Well-being Scale, Meaning in Life Questionnaire, Satisfaction with Life Scale, Well-being Index and Symptom Checklist-90-Revised. Therapists completed treatment related data and an opinion survey of patient´s progress, adherence to treatment and therapeutic relationship. Findings showed positive variables to be higher at the final stage of psychotherapy, particularly higher satisfaction with life, engagement, well-being, and presence of meaning in life. Higher positive variables were moderately associated with more progress during treatment according to therapist’s perspective; however a low association was found with adherence to treatment and therapeutic relationship. No differences were found in positive variables according the type of prevalent symptoms.
Perceptions of close relationship through the Machiavellians´ dark glasses: Negativity, distrust, self-protection against risk and dissatisfaction
Authors: Ináncsi Tamás , Pilinszki Attila , Paál Tünde , Láng András
Published: November 2018

It is commonly known from the literature that Machiavellian individuals have negative attitudes towards people and in general towards the world´s affairs. They are distrustful of the intentions of others, and they get cautiously involved into interpersonal interactions and take risks only if that may not have any severe negative consequence. It is also a fact that there are few ventures in life that potentially involve as much insecurity and personal vulnerability as the establishment and maintenance of close relationships. In our study, we were seeking the answer to the question: do people with high levels of Machiavellianism show a generally negative, distrustful and cautious attitude in their intimate relationships, as well? What effect their pessimistic approaches have on the other consequences of the relationship (satisfaction, commitment, investment, quality of alternatives)? This question was investigated on a dyadic sample of heterosexual couples (N = 101 pairs) with Actor-Partner Interdependence Model (APIM). The results of the correlations and actor effects show that men with high levels of Machiavellianism perceive in a negative way not just people in general, but their romantic partners and relationships as well and they experience an increased level of distrust, risk, and dissatisfaction into their close relationships. Women with high levels of Machiavellianism are less negativistic and feel less discontent towards their intimate partner and relationship, but even they are unable to put their distrust and precaution aside. The results of partner effects have revealed that women's Machiavellianism undermines men's trust, while men's Machiavellianism has the effect of minimizing women's investment into their relationship.
On the very-long-term effect of managing one’s own memory: The intention to forget improves recognition after a year’s delay
Authors: Nourkova Veronika V. , Gofman Alena A. , Kozlov Mikhail D.
Published: November 2018

While such factors as demand characteristics, encoding, and retrieval inhibition were shown to be significant in producing the directed forgetting effect, no attention was paid to whether the intention to manage one’s own memory, per se, matters. In the present article, we addressed this important gap in the literature. To control the quality of encoding we ensured that both the to-be-remembered (TBR) and to-be-forgotten (TBF) items were genuinely learned before the manipulation. We used extremely long delays between the memory instructions and testing to release inhibition associated with the content of instructions. 98 participants demonstrated flawless recall of 12 Russian - made up language word pairs. They then viewed each Russian word from a pair once, with randomized instructions “Forget”, “Remember”, “Repeat”, or a short cognitive task. Self-reports on the mnemonic strategies were collected. Free recall and recognition tests were administered three times - 45 minutes, a month and a year (N = 58) later. Despite a strong incentive to recall all word pairs, fewer TBF pairs were recalled in comparison with TBR pairs, both after 45 minutes and after one month’s delay. Recognition among all conditions was equally high. A year later free recall was close to zero. In contrast, the TBR and TBF pairs were recognized equally better than pairs presented in “Repeat” and “Task” conditions. Thus, our results show that the intention to manage one’s own memory enhances the accessibility of memories at a very long time delay, no matter what type of instruction is issued.
Coreólogo/Notador – uma profissão?
Authors: Trindade Ana Lígia
Published: November 2018

O processo de registrar o movimento no papel não é um fenômeno novo, contudo, somente neste século a notação tem sido usada profissionalmente. Este artigo é uma análise da notação do movimento como uma carreira. Não uma carreira fácil, mas desafiadora O texto trás conceitos e definições a cerca dos termos “coreólogo” e “notador”. Abre discussão sobre a profissão e seu mercado de trabalho no Brasil e no mundo. As notações foram e vem se especializando em descrever o movimento qualitativamente e quantitativamente, dissecando-o em elementos que formamo alfabeto corporal. O estudo deste material vem ganhando grande confiabilidade nas produções de dança no mundo. Conhecê-las e eventualmente especializar-se como umcoreólogo/notador é mais uma opção no campo profissional da área, que tem sido adotado nas grandes e renomadascompanhias de dança.
Sem tela, sem pincel, sem tinta
Authors: Eger Rita de Cássia Schipmann
Published: November 2018

Este trabalho é um dos desdobramentos da busca por uma maneira de apresentar as idéias geradas pela apropriação dasformas do conjunto de algumas taças de cristal quebradas. É um dos resultados de uma vasta experimentação de ações quevisam ressignificar estes objetos que perderam sua função utilitária, mas ganharam grande potencial artístico. Na verdade o trabalho consiste em estabelecer novas relações a estes objetos que saíram das suas significações, das suas relações de uso ehábito cotidiano.
Como trabalhar teatro na sala de aula?
Authors: Aschermann Camila , Rodrigues Eder Sumariva
Published: November 2018

A abordagem deste relato de experiência é realizar uma reflexão dos procedimentos metodológicos e dos resultados adquiridos durante o processo de estágio V em 2005/2 e apresentar uma proposta uma nova forma para trabalhar o teatro na rede pública de ensino.
Salvador Dali e Amélia Toledo – Muito além de nossas emoções e sensibilidades
Authors: Pinto Sandra Regina Clara Nepomoceno
Published: November 2018

Neste texto falaremos de dois artistas que muito acrescenta ao Universo da Arte com seus trabalhos. O valioso presente que o mundo recebeu e que devemos ter muitos seguidores e admiradores aplaudindo sempre a cada dia e agradecendo à importância desses mestres da arte. Falaremos de SalvadorDali na Arte Moderna e de Amélia Toledo na Arte Contemporânea. Também será visto a criatividade do trabalhoacadêmico prático, desenvolvido na disciplina de ‘Análise de Técnicas e Materiais Expressivos I em 2007-1’.
Apontando os tópicos
Authors: Carvalho Silvia
Published: November 2018

Resenha de: BRITES, Blanca, TESSLER, Elida (organizadoras). O meio como ponto zero. Metodologia da pesquisa em artes plásticas. Porto Allegre: Editora da Universidade UFRGS,2002. O livro “O meio como ponto zero”, apresenta diferentes conceitos de pesquisadores na área das artes plásticas no âmbito universitário. Tecendo idéias, sugestões, conceitos a fim de articular a construção de um pensamento prático-teórico que envolve o artista- pesquisador. Nesse texto vou citar algumas colocações relevantes de alguns dos pesquisadores participantes.
Programa Nupeart: Sistematizando Ações de Ensino, Pesquisa e Extensão
Authors: Silva Maria Cristina da Rosa Fonseca da , Schambeck Regina Finck , Ribeiro Luciana Renata , Marcelino Luciana
Published: November 2018

O presente artigo tem como objetivo apresentar as ações de extensão ocorridas no programa NUPEART: Uma articulação CEAD e CEART. O NUPEART foi criado no ano de 2000 por um grupo de professores atuantes na área de ensino de arte com o objetivo de atender as demandas e lacunas no contexto do ensino de arte e formação de professores. No presente texto, buscamos relatar as experiências de articulação de ensino, pesquisa e extensão, ocorridas no programa no ano de 2010. A essas experiências acoplamos a realização do Ciclo expositivo: Educação, Arte e Inclusão proposto com recursos do edital de cultura da UDESC.
Aulas de Música em Projetos de Assistência Social
Authors: Uriarte Mônica Zewe , Nunes Thales de Godoi
Published: November 2018

Este artigo objetiva relatar aulas de música ministradas por acadêmicos do curso de Licenciatura em Música, realizadas através do projeto de extensão “Articulando a Educação Musical em Projetos de Assistência Social”. O projeto busca desenvolver aspectos musicais relacionados à prática de atividades de percepção, execução instrumental e vocal, promovendo a socialização e o trabalho em equipe através do estudo de violão. Os participantes são adolescentes entre 11 e 13 anos de idade, parte integrante de um Centro de Referência de Assistência Social – CRAS – no município de Itajaí, SC. Os resultados até agora obtidos, indicam fatores relevantes como as questões sociais, culturais e econômicas que influenciam consideravelmente na escolha do repertório e aplicação de metodologias. Por outro lado, foi possível perceber que a modalidade de trabalho musical proposta, possibilitou aos alunos a estimulação de suas habilidades musicais, colaborando com o seu desenvolvimento artístico e social.
A teoria e a prática na construção do conhecimento
Authors: Zanette Rafael Augusto
Published: November 2018

Este trabalho tem o intuito de levantar questões a respeito da aplicabilidade das teorias pedagógicas na prática cotidiana da sala de aula. Por se tratar de uma análise a partir de uma experiência proposta em aulas de Artes – especificamente aulas de Teatro – para crianças de 07 a 09 anos, sua pertinência baseia-se na questão de tornar o universo artístico encantador aos alunos, sem que suas proposições se distanciem das experiências de vida das crianças. Como tornar o ensino de Artes interessante, quando o estagiário/professor se vê concorrendo com um bombardeamento midiático tão poderoso e atraente como a internet, os videogames e as redes sociais? Não cabe aqui questionar tais “requisitos” da vida sociocultural da humanidade mas sim, analisar a postura e a pertinência da figura do educador em relação às ferramentas contemporâneas utilizadas para alcançar o (dito) conhecimento. Ao final do trabalho, propomos uma ação metodológica para aulas de teatro que abarca o universo da contação de histórias infantis.
O ensino de música no ensino médio: reflexões a partir do Projeto PIBID Música UEMG
Authors: Silva Helena Lopes da
Published: November 2018

Este artigo discute a implementação da Lei nº 11.769/08, que instituiu a música como conteúdo obrigatório da educação básica, a partir da natureza e das possibilidades do ensino de música no espaço escolar. Através de um relato acerca do PIBID Música da Universidade do Estado de Minas Gerais (UEMG) desenvolvido em duas escolas públicas de Belo Horizonte, apresenta-se a ativi- dade de escuta musical como uma prática musical e como possibi- lidade metodológica para o ensino de música no Ensino Médio.
Jandira Lorenz: entre os desenho e a docência
Authors:   Universidade do Estado de Santa Catarina, Vasconcelos Helena Villas Garcia
Published: November 2018

Baseada na história oral como técnica de pesquisa, procurei fazer um resgate da história do Centro de Artes (CEART) da Universidade do Estado de Santa Catarina (UDESC) entrevistando uma professora aposentada do Departamento de Artes Visuais. A entrevista com Jandira Lorenz foi realizada em um estúdio de arte vítrea na Lagoa da Conceição em Florianópolis. Na primeira parte do texto apresento a entrevistada e a criação do CEART. Logo em seguida, busquei discorrer sobre a docência para Jandira, onde a professora narra sobre a sua escolha pela profissão e a sua formação. Histórias sobre as disciplinas e a convivência com os colegas professores do CEART, também fazem parte desta narrativa. E para finalizar, trago o relato feito por Jandira sobre a representação do CEART na sua vida. Através do olhar desta professora é possível conhecer um pouco da história e de fatos importantes que aconteceram dentro do Centro de Artes.
O Sonho que sobrevive: uma resenha do livro póstumo de Dora Bay
Authors: Oliveira Sandra Regina Ramalho
Published: November 2018

Homenagem.
I LL U S T R O I M A G O: palavras sobre imagens
Authors:   UDESC, Oliveira Sandra Regina Ramalho
Published: November 2018

Homenagem.
Duas páginas para o Zé
Authors: Melim Regina
Published: November 2018

Homenagem.
Analyses of conformational performance differentiation among functional breeding goals in the Menorca horse breed
Authors: Solé M. , Gómez M. D. , Molina A. , Peña F. , Valera M.
Published: November 2018

Abstract. The endangered Menorca horse from the Balearic Islands (Spain) is selected for its economically viable traits, such as conformation and dressage performance, while maintaining the maximum possible genetic variability. The aim of this work was to describe the morphology of the Menorca horse and to analyse the conformational variation among the different performance aptitudes of the males (classical dressage, Menorca dressage and leisure) using 47 body measurements and 10 body indices. The data consists of 147 females and 200 males. The Menorca horse can be characterised as an animal of quadrangular format, slim figure with thin and long limbs, with the greatest values for height and length found in the males. The Duncan and principal component analysis with non-linear iterative partial least-squares algorithm discriminates the Menorca dressage group mainly by its differential hind limb angulations. Both the classical and Menorca dressage groups showed well-balanced body proportions for sport performance.
The double role of pigmentation and convolute leaves in community assemblage of Amazonian epiphytic Lejeuneaceae
Authors: Mota de Oliveira Sylvia
Published: November 2018

Background

Epiphytic bryophyte communities in the Amazon forest show a vertical gradient in species composition along the trunk of the host trees. The investigation of species traits related to this pattern has focused on the physiology of selected taxa with a clear preference for one of the extremes of the gradient. Although some species are indeed only found on the tree base or in the outer canopy, the vertical gradient is composed mainly by the variation in the abundances of species with a broader occurrence along the height zones. Therefore, this study approaches the differences among community assemblages, rather than among species, to test the role of morphological and dispersal traits on the establishment of the vertical gradient in species composition.

Methods

A character state matrix was built for 104 species of the family Lejeuneaceae recorded as epiphytes in the Amazonian terra firme forests, and six binary traits supposed to influence species occurrence: dark pigmentation on leaves; ability to convolute leaves when drying; possession of thickened cell walls; reproduction mode (monoicous or dioicous); occurrence of asexual reproduction; and facultative epiphyllous habit. Based on a previous dataset on community composition along the vertical gradient, trait occurrences in random draws of the metacommunity was compared to trait occurrences in field data, in order to detect significant deviations in the different height zones.

Results

Four out of the six traits tested showed significantly higher or lower occurrence in the species composition of canopy and/or understory communities. Traits related to high dispersal ability did not vary much along the vertical gradient; although facultative epiphylls were overrepresented on tree base. Dark pigmentation and convolute leaves were significantly more frequent in the canopy communities, but also significantly less frequent in communities at the base of the tree.

Discussion

Dark pigmentation and convolute leaves seem to be advantageous for the establishment in the canopy zones. They may, respectively, prevent light damage and allow longer periods of photosynthesis. Interestingly, these traits occur randomly along the trunk, but are wiped out of communities on the tree base. In the relatively deep shade of the first meters of the understory, they possibly hamper net carbon gain, the first by darkening the leaf surface and the second by delaying desiccation—which can be damaging under high temperatures and low light. The fact that production of asexual propagules is not overrepresented in the most dynamic microenvironment along the gradient, the canopy, challenges current views of bryophyte life strategy theory.
АНТРАЦЕНСОДЕРЖАЩИЕ ПОДАНДЫ - ИОНАКТИВНЫЕ МОЛЕКУЛЯРНЫЕ ПЕРЕКЛЮЧАТЕЛИ ФЛУОРЕСЦЕНТНЫХ СВОЙСТВ, "Журнал органической химии"
Authors: Брень В.А. , Толпыгин И.Е. , Ревинский Ю.В. , Тихомирова К.С. , Дубоносов А.Д.
Published: November 2018

Синтезированы 2,2'-[этан-1,2-диилбис(окси)]бис[N-(антрацен-9-илметил)этанамин] и его бисфенилтиомочевинные и бистиомочевинные производные. Диамин, являющийся своеобразным аналогом азакраун-эфира с открытой цепью, демонстрирует увеличение относительной интенсивности флуоресценции в 50 раз (off-on процесс) в присутствии катионов кадмия(II). Бис(фенилтиомочевина) представляет собой бифункциональный флуорофор, реагирующий на катионы ртути(II) (разгорание эмиссии) и фторид-анионы (тушение эмиссии). Анионы F, CN, HPOи AcO вызывают практически полное «выключение» флуоресцентных свойств бис(тиомочевины) (on-off процесс).
ГИДРОКСИЛАМИН В ПРЕВРАЩЕНИЯХ ПЕРЕКИСНЫХ ПРОДУКТОВ ОЗОНОЛИЗА АЛКЕНОВ, "Журнал органической химии"
Authors: Легостаева Ю.В. , Гарифуллина Л.Р. , Назаров И.С. , Ишмуратова Н.М. , Ишмуратов Г.Ю.
Published: November 2018

Изучены превращения пероксидных продуктов озонолиза линейных и циклических алкенов под действием гидроксиламина, полученного in situ из NHOHHCl нейтрализацией хлороводорода ацетатом натрия. Осуществлена однореакторная последовательность окисление алкена озоном восстановление до карбонильного соединения гидроксиламином конденсация карбонильного соединения с гидроксиламином, дающая возможность прямого превращения алкенов в кето- и альдоксимы, исключая стадию получения и выделения карбонильного соединения.
СИНТЕЗ ЛЦАДАМАНТАН-1-ИЛ)КАРБАМИДОВ ПО РЕАКЦИИ РИТТЕРА ИЗ АДАМАНТАН-1-ОЛА И НИТРИЛОВ В ПРИСУТСТВИИ Cu-КАТАЛИЗАТОРОВ, "Журнал органической химии"
Authors: Байгузина А.Р. , Лутфуллина А.Р. , Хуснутдинов Р.И.
Published: November 2018

Осуществлен селективный синтез (Z)-N-(адамантан-1-ил)карбамидов при взаимодействии адамантан-1-ола с нитрилами в присутствии Cu-катализаторов. Z-Конформация амидов установлена на основе данных РСА и 2D ЯМР.
ТРЕХКОМПОНЕНТНЫЙ СИНТЕЗ И ОПТИЧЕСКИЕ СВОЙСТВА ЭФИРОВ НИКОТИНОВОЙ КИСЛОТЫ, СОДЕРЖАЩИХ БУТА-1,3-ДИЕН-1,1,3-ТРИКАРБОНИТРИЛЬНЫЙ ФРАГМЕНТ, "Журнал органической химии"
Authors: Бардасов И.Н. , Алексеева А.Ю. , Чунихин С.С. , Ершов О.В.
Published: November 2018

Разработан трехкомпонентный синтез этил 4-арил-2-метил-5-циано-6-(дицианометилен)-1,6- дигидропиридин-3-карбоксилатов, заключающийся во взаимодействии ацетоуксусного эфира, ароматических альдегидов и димера малононитрила в присутствии нитрита натрия. Изучены оптические свойства синтезированных соединений и показано, что они обладают интенсивной флуоресценцией в растворе и в твердом состоянии с максимумами испускания в зеленой и желтой областях видимого света.
МАСС-СПЕКТРЫ НОВЫХ ГЕТЕРОЦИКЛОВ. XVII.* ОСНОВНЫЕ ЗАКОНОМЕРНОСТИ ФРАГМЕНТАЦИИ МОЛЕКУЛЯРНЫХ ИОНОВ 4- АЛКОКСИ-5-АМИНО-3-МЕТИЛТИОФЕН-2-КАРБОНИТРИЛОВ В УСЛОВИЯХ ЭЛЕКТРОННОЙ И ХИМИЧЕСКОЙ ИОНИЗАЦИИ, "Журнал органической химии"
Authors: Клыба Л.В. , Недоля Н.А. , Санжеева Е.Р. , Тарасова О.А.
Published: November 2018

Впервые изучен распад 4-алкокси-5-амино-3-метилтиофен-2-карбонитрилов в условиях электронной (70 эВ) и химической (газ-реагент - метан) ионизации. При ионизации электронами исследуемые соединения [за исключением 4-(1-этоксиэтокси)- и 4-(ферроценилметокси)производных] образуют устойчивые молекулярные ионы, основным направлением распада которых является отрыв алкильного радикала из алкокси-заместителя. Дальнейшая фрагментация образующегося иона [M- Alk] зависит от природы заместителя в аминогруппе. В масс-спектре 4-(ферроценилметокси)- замещённого тиофена преобладают пики иона [FcCH] и продуктов его деградации. В масс- спектрах химической ионизации доминируют пики ионов M', [М + Н] и [М + CH], и отсутствуют пики фрагментных ионов.
СИНТЕЗ 2- [3-АРИЛ-3-(5-ФЕНИЛИЗОКСАЗОЛ-3-ИЛ)ПРОПИЛ] ПРОИЗВОДНЫХ 5,5-ДИМЕТИЛЦИКЛОГЕКСАН- И ЦИКЛОПЕНТАН-1,3-ДИОНОВ НА ОСНОВЕ 2-(4-НИТРО-3-АРИЛБУТИЛЬНЫХ) ПРЕДШЕСТВЕННИКОВ, "Журнал органической химии"
Authors: Донцу Ю.С. , Пашковский Ф.С. , Рубинов Д.Б. , Лахвич Ф.А.
Published: November 2018

Осуществлено региоспецифическое восстановление карбонильной группы ацильной цепи описанных нами ранее 4-нитро-3-арилбутаноилпроизводных димедона и циклопентан- 1,3-диона. На основе нитрометильной группы енолпроизводных продуктов восстановления указанных соединений генерированы нитрилоксидные интермедиаты, которые вводили в реакцию с фенилацетиленом с образованием соответствующих изоксазольных производных.
СИНТЕЗ И ХИМИЧЕСКИЕ ПРЕВРАЩЕНИЯ 5-АЛКИЛ(ФЕНИЛ)- 4,5,6,7-ТЕТРАГИДРО[1,2,4]ТРИАЗОЛО[1,5-а]ПИРИМИДИН-7-ОЛОВ, "Журнал органической химии"
Authors: Земляная Н.И. , Карножицкая Т.М. , Мусатов В.И. , Коновалова И.С. , Шишкина С.В. , Липсон В.В.
Published: November 2018

Циклоконденсацией 3-амино-1,2,4-триазола с 4-метилпент-3-ен-2-оном синтезирован 5,5,7-триметил-4,5,6,7-тетрагидро[1,2,4]триазоло[1,5-a]пиримидин-7-ол; изучены его химические превращения, а также превращения 5-фенил-4,5,6,7-тетрагидро[1,2,4]триазоло[1,5-a]пиримидин-7-ола в реакциях с реагентами различной электронной природы.
ТРЕХКОМПОНЕНТНЫЙ СТЕРЕОСЕЛЕКТИВНЫЙ СИНТЕЗ (1Я,2А)-1-АРИЛ- 2- {[ПРОП-2-ИН(ЕН)ИЛОКСИ] МЕТИЛ }СПИРО [2,4] ГЕПТА-4,7-ДИОНОВ, "Журнал органической химии"
Authors: Талыбов Г.М.
Published: November 2018

Трехкомпонентное взаимодействие с участием циклопентан-1,3-диона, замещенных бензальдегидов и хлорметилпропин(ен)овых эфиров с удовлетворительным выходом приводит к стереоселективному образованию транс-1-арил-2-{[проп-2-(ин)енилокси]метил}спиро[2,4]гепта-4,7-дионов.
3-ПОЛИФТОРАЛКИЛ-1,5-ДИФЕНИЛПИРАЗОЛЫ В РЕАКЦИЯХ КРОСС-СОЧЕТАНИЯ СУЗУКИ, "Журнал органической химии"
Authors: Иванова А.Е. , Бургарт Я.В. , Салоутин В.И.
Published: November 2018

При кросс-сочетании Сузуки из 3-полифторалкил-1,5-дифенилпиразолов получены 4-(гет)арил-3- полифторалкил-1,5-дифенилпиразолы.
НАХОЖДЕНИЕ ВЕКТОРА УКЛОНОВ ВЗВОЛНОВАННОЙ ВОДНОЙ ПОВЕРХНОСТИ ПО ЕЁ ИЗОБРАЖЕНИЮ В УСЛОВИЯХ ЕСТЕСТВЕННОГО ОСВЕЩЕНИЯ, "Фундаментальная и прикладная гидрофизика"
Authors: Турлаев Д.Г.
Published: November 2018

Представлены некоторые результаты апробации алгоритма восстановления вектора уклонов взволнованной водной поверхности по её изображению, полученному в условиях естественного освещения при ясном, безоблачном небе. Для эксперимента использовался надувной бассейн диаметром ~ 2 м. Для ослабления сигнала обратного рассеяния вода насыщалась нигрозином. Изображения фиксировались на цифровую фотокамеру. Волнение создавалось вручную. Кроме изображения взволнованной водной поверхности использовалась фотография «зеркального» участка небосвода, отражённого в воде в отсутствие волнения. Используется приближение, в рамках которого распределение яркости неба, отражённого в спокойной воде, в пределах кадра может считаться линейным. В указанных выше условиях, была найдена компонента вектора уклонов, коллинеарная градиенту яркости небосвода. Для её нахождения использовалось изображение взволнованной водной поверхности и фотография того же участка воды в отсутствие волнения. Вторая компонента определялась непосредственно по найденной, используя тот факт, что обе компоненты вектора уклонов являются производными одной скалярной функции - функции возвышений водной поверхности. Используемый алгоритм позволял с приемлемой точностью найти уклоны волн, бегущих в разных направлениях, кроме тех, что распространялись вблизи нормали к градиенту яркости неба.
ОТРАЖАТЕЛЬНЫЕ СВОЙСТВА АРКТИЧЕСКОГО ЛЕТНЕГО ЛЬДА В ВИДИМОМ И ИНФРАКРАСНОМ ДИАПАЗОНАХ, "Фундаментальная и прикладная гидрофизика"
Authors: Зеге Э.П. , Малинка А. В. , Кацев И.Л. , Прихач А.С. , Истомина Л. , Хейгстер Г. , Сприн Г.
Published: November 2018

Представлен краткий обзор работ авторов, в которых развита аналитическая теория спектральных оптических характеристик различных типов морского льда как рассеивающей среды (коэффициентов ослабления и поглощения, индикатрисы рассеяния), а также модели отражения ледовым покрытием в Арктике. Лед моделируется как статистически однородная случайная смесь лед-воздух-вода с крупным (по сравнению с длиной волны излучения) масштабом неоднородностей. Параметры смеси (концентрации и размеры неоднородностей) определяются генезисом и положением слоев льда. Во всех случаях масштаб неоднородностей много больше длины волны света. Для определения оптических характеристик различных типов морского льда развиты теории рассеяния света стохастической смесью в приближениях геометрической оптики и Вентцеля-Крамерса-Бриллюэна. Спектральное отражение ледовыми полями описывается в рамках асимптотической теории распространения света в оптически толстых слабопоглощающих слоях. Для описания оптических характеристик тающего (летнего) льда развита модель отражения света прудом талой воды на льду (снежницей). Таким образом определяются все оптические характеристики арктического льда, которые необходимы в качестве входных данных для расчёта переноса излучения. Показано хорошее совпадение полученных результатов с данными измерений, выполненных в ряде арктических экспедиций. Развиты методы атмосферной коррекции спутниковых и полевых данных.
Stereoselective catalysis controlled by a native leucine or variant isoleucine wing‐gatekeeper in 2‐haloacid dehalogenase
Authors: Feng Yanbin , Wang Yayue , Chu Huiying , Fan Yan , Cao Xupeng , Liu Yinghui , Li Guohui , Xue Song
Published: November 2018

Comprehensively understanding enzymatic stereoselectivity will assist in the creation of new enzymes for producing optically pure compounds for chemical applications. The essential features for selecting enantiomers are controlled by particular residues or regions of the enzymes. We report a stereoselective mechanism in the D‐2‐haloacid dehalogenase HadD AJ1, in which L288 is identified as a gatekeeper in the access channel that strictly recognizes D‐enantiomers. Mutagenesis of L288 to isoleucine (I) enlarges the size of the channel and allows the enzyme to accommodate L‐enantiomers. Furthermore, the wing flip of I288 induces hydrophobic interactions with the L‐enantiomer and directly affects the catalytic efficiency. The results illustrate the dynamic catalytic mechanisms of Leu‐Ile gatekeepers and provide knowledge for unveiling the basis of stereospecificity in biocatalysts.

image
The impact of alcohol intoxication on witness suggestibility immediately and after a delay
Authors: Evans Jacqueline R. , Schreiber Compo Nadja , Carol Rolando N. , Nichols‐Lopez Kristin , Holness Howard , Furton Kenneth G.
Published: November 2018

Intoxicated witnesses are common, making it important to understand alcohol's impact on witness accuracy and suggestibility. Participants assigned to an immediate retrieval condition encoded and recalled in one of the three intoxication conditions: sober control, placebo, or intoxicated. Participants in the delayed retrieval condition were assigned to encode in one of the three intoxication conditions, returned a week later, and were assigned to retrieve in one of the three intoxication conditions. Intoxication condition at encoding was fully crossed with intoxication condition at retrieval in the delayed condition. Participants encoded a mock crime video and retrieved via a forced‐choice test, with answers already circled (purportedly by a prior participant); half of the precircled responses were incorrect. When recalling after a delay only, intoxication at encoding increased agreement with incorrect suggested answers and decreased accuracy. Results suggest intoxicated witnesses may benefit from being interviewed immediately rather than after a sobering delay.
Taking a new look at seductive details
Authors: Mayer Richard E.
Published: November 2018

What is the effect of seductive details on learning outcomes? What are the boundary conditions of seductive detail effects? How do seductive details affect learning? These are the kinds of questions addressed in this special issue on seductive details. This special issue contains 11 articles presenting original results that take a new look at seductive details.
Mechanical Properties of PEEK‐Derived C/SiC Composites with Different Fiber Lengths
Authors: Liensdorf Tom , Langhof Nico , Krenkel Walter
Published: November 2018

Short fiber reinforced C/SiC composites are advantageous compared to continuously reinforced ceramic matrix composites (CMC) in terms of their net‐shape manufacturing and cost efficiency. These composites have promising planar isotropic thermophysical properties. In this work, a novel approach is introduced by applying polyetheretherketone (PEEK) as a thermoplastic carbon‐precursor for C/SiC with thermally pre‐treated carbon fibers with different fiber lengths (6–24 mm) or bimodal fiber length distributions. The resulting material shows a flexural strength of up to 117 MPa. With a bimodal fiber distribution, a more homogeneous microstructure and the highest flexural strength are obtained. As there is no standardization method for testing short fiber reinforced ceramic materials, this work also explores and discusses the influence of the different testing methods on the mechanical properties.
Relaxor Behavior in Ordered Lead Magnesium Niobate (PbMg1/3Nb2/3O3) Thin Films
Authors: Shetty Smitha , Damodaran Anoop , Wang Ke , Yuan Yakun , Gopalan Venkat , Martin Lane , Trolier‐McKinstry Susan
Published: November 2018

The local compositional heterogeneity associated with the short‐range ordering of Mg and Nb in PbMg1/3Nb2/3O3 (PMN) is correlated with its characteristic relaxor ferroelectric behavior. Fully ordered PMN is not prepared as a bulk material. This work examines the relaxor behavior in PMN thin films grown at temperatures below 1073 K by artificially reducing the degree of disorder via synthesis of heterostructures with alternate layers of Pb(Mg2/3Nb1/3)O3 and PbNbO3, as suggested by the random‐site model. 100 nm thick, phase‐pure films are grown epitaxially on (111) SrTiO3 substrates using alternate target timed pulsed‐laser deposition of Pb(Mg2/3Nb1/3)O3 and PbNbO3 targets with 20% excess Pb. Selected area electron diffraction confirms the emergence of (1/2, 1/2, 1/2) superlattice spots with randomly distributed ordered domains as large as ≈150 nm. These heterostructures exhibit a dielectric constant of 800, loss tangents of ≈0.03 and 2× remanent polarization of ≈11 µC cm−2 at room temperature. Polarization–electric field hysteresis loops, Rayleigh data, and optical second‐harmonic generation measurements are consistent with the development of ferroelectric domains below 140 K. Temperature‐dependent permittivity measurements demonstrate reduced frequency dispersion compared to short range ordered PMN films. This work suggests a continuum between normal and relaxor ferroelectric behavior in the engineered PMN thin films.
Exploiting In Situ Redox and Diffusion of Molybdenum to Enable Thin‐Film Circuitry for Low‐Cost Wireless Energy Harvesting
Authors: Son Youngbae , Peterson Rebecca L.
Published: November 2018

Direct additive fabrication of thin‐film electronics using a high‐mobility, wide‐bandgap amorphous oxide semiconductor (AOS) can pave the way for integration of efficient power circuits with digital electronics. For power rectifiers, vertical thin‐film diodes (V‐TFDs) offer superior efficiency and higher frequency operation compared to lateral thin‐film transistors (TFTs). However, the AOS V‐TFDs reported so far require additional fabrication steps and generally suffer from low voltage handling capability. Here, these challenges are overcome by exploiting in situ reactions of molybdenum (Mo) during the solution‐process deposition of amorphous zinc tin oxide film. The oxidation of Mo forms the rectifying contact of the V‐TFD, while the simultaneous diffusion of Mo increases the diode's voltage range of operation. The resulting V‐TFDs are demonstrated in a full‐wave rectifier for wireless energy harvesting from a commercial radio‐frequency identification reader. Finally, by using the same Mo film for V‐TFD rectifying contacts and TFT gate electrodes, this process allows simultaneous fabrication of both devices without any additional steps. The integration of TFTs alongside V‐TFDs opens a new fabrication route for future low‐cost and large‐area thin‐film circuitry with embedded power management.
Alkylamino‐Directed One‐Pot Reaction of N‐Alkyl Anilines with CO, Amines and Aldehydes Leading to 2,3‐Dihydroquinazolin‐4(1H)‐ones
Authors: Zhang Xiaopeng , Li Zhengwei , Ding Qianqian , Li Xiaochuan , Fan Xuesen , Zhang Guisheng
Published: November 2018

An economical and efficient approach to pharmaceutically and biologically significant 2,3‐dihydroquinazolin‐4(1H)‐ones has been disclosed. The one‐pot multicomponent reaction was performed through a palladium‐catalyzed ortho‐selective oxidative carbonylation of N‐substituted anilines with CO and primary amines, and subsequent condensation with aldehydes in MeCN by using alkylamino as the directing group, KI/AcOH as the additives, and Cu(OAc)2 as the oxidant. This intriguing straightforward method features embedded directing strategy, simple starting materials, mild conditions, high atom/step economic economy, broad substrate scope and good product diversity.

magnified image
Advanced Near‐Infrared Light‐Responsive Nanomaterials as Therapeutic Platforms for Cancer Therapy
Authors: Chien Yi‐Hsin , Chan Kok Ken , Anderson Tommy , Kong Kien Voon , Ng Beng Koon , Yong Ken‐Tye
Published: November 2018

Cancer is one of the leading causes of death. Despite the huge progress in the field of cancer drugs and therapies, the treatment outcome is still bleak for most cancer patients. Nanotechnology has revolutionized cancer therapeutics. By using nano‐sized particles as delivery systems, therapeutic biomolecules are transported efficiently to the target sites. Moreover, these particles are designed to carry out multiple cancer treatments simultaneously. Near‐infrared (NIR) light‐responsive nanomaterials have gained much attention as NIR light has a greater penetration depth, minimal phototoxicity, lower autofluorescence, and reduced light scattering. Among the available NIR light‐responsive nanomaterials, gold nanorods, upconversion nanoparticles, carbon dots, transition metal dichalcogenide, metal oxides, black phosphorus, and polymeric nanomaterials have become attractive options owing to their excellent optical properties, ease of synthesis and modification, outstanding photodynamic and photothermal conversion properties, and most importantly, favorable toxicity level and biocompatibility which are prerequisites for biological applications. In this review, the outstanding properties, synthesis, and surface functionalization of the aforementioned NIR light‐responsive nanomaterials are introduced in detail. Recent advances of these nanomaterials for various cancer treatment modalities are summarized to highlight their versatility and potential in cancer theranostics. Finally, a perspective is proposed on future research directions and their clinical translation.
Magnetic Supramolecular Nanofibers of Gold Nanorods for Photothermal Therapy
Authors: Yu Qilin , Zhang Ying‐Ming , Liu Yao‐Hua , Liu Yu
Published: November 2018

Molecular aggregation triggered by physical and chemical stimuli and based on multiple noncovalent interactions has immense potential utility for modeling and mimicking biological systems and for the diagnosis and treatment of degenerative diseases. Herein the preparation, properties, and biological activities of a new type of organic–inorganic hybrid supramolecular nanofiber composed of gold nanorods, mitochondrion‐targeting‐peptide‐coated iron oxide nanoparticles, and hyaluronic‐acid (HA)‐modified β‐cyclodextrin is reported. These photothermal nanofibers, which grew along the direction of the geomagnetic field, induced severe mitochondrial damage in human adenocarcinoma cells (A549); and, more strikingly, the nanofibers greatly suppress metastasis and clear A549 cells in tumor‐bearing mice upon irradiation with a near‐infrared laser. The ability to recruit HA‐receptor‐expressing tumor cells and to target mitochondria, as well as the high photothermal conversion efficiency imparted by the gold nanorods, makes these supramolecular nanofibers a promising nanotherapy for cancer in general and metastasis‐related malignancy in particular.
Paternity data and relative testes size as measures of level of sperm competition in the Cercopithecoidea
Authors: Baker R. Robin , Shackelford Todd K.
Published: November 2018

Historically, the empirical study of the role of sperm competition in the evolution of sexual traits has been problematic through an enforced reliance on indirect proxy measures. Recently, however, a procedure was developed that uses paternity data to measure sperm competition level directly in terms of males/conception (i.e., the number of males that have sperm present in a female's ampulla at conception). When tested on apes and humans (Hominoidea) this measure proved not only to correlate significantly with the traditionally used measure of relative testes size but also to offer a number of advantages. Here we provide a second test of the procedure, this time using paternity data for the Old World monkeys (Cercopithecoidea). We calculate sperm competition levels (males/conception) for 17 species of wild and free‐ranging cercopithecoids and then analyze the data against measures of relative testes size. Calculated sperm competition levels correlate strongly with relative testes size both with and without phylogenetic control at both the species and generic levels. The signal‐to‐noise ratios inherent in both the past measure of relative testes size and the new measure of sperm competition level from paternity data are discussed. We conclude that although both measures are appropriate for the future study of the role of sperm competition in the evolution of sexual traits, when paternity data are available they provide the more direct and meaningful analytical tool. Not least, they potentially allow a first empirical analysis of the role of sperm competition in the evolution of relative testes size that could then be compared with the wealth of theoretical analyses that already exist.