bluuebunny/crossref_metadata_2025 huggingface dataset:
Managing the economic challenges in the treatment of heart failure
Authors: Piña Ileana L. , Allen Larry A. , Desai Nihar R.
Published: December 2021

Background

Treatment of heart failure is complex and inherently challenging. Patients traverse multiple practice settings as inpatients and outpatients, often resulting in fragmented care. The Center for Medicare and Medicaid Services is implementing payment programs that reward delivery of high-quality, cost-effective care, and one of the newer programs, the Bundled Payment for Care Improvement Advanced program, attempts to improve the coordination of care across practices for a hospitalization episode and post-acute care. The quality and cost of care contribute to its value, but value may be defined in different ways by different entities.

Conclusions

The rapidly changing world of digital health may contribute to or detract from the quality and cost of care. Health systems, payers, and patients are all grappling with these issues, which were reviewed at a symposium at the Heart Failure Society of America conference in Philadelphia, Pennsylvania on September 14, 2019. This article constitutes the proceedings from that symposium.
A case of anterior persistent hyperplastic primary vitreous associated with morning glory disc anomaly and retinopathy of prematurity like retinopathy in a term-born child
Authors: Zhang Hao , She Kaiqin , Lu Fang
Published: December 2021

Background

Association of morning glory disc anomaly (MGDA) with persistent hyperplastic primary vitreous (PHPV) has been reported earlier. Retinopathy of prematurity (ROP) like retinopathy in preterm babies with optic disc anomalies has also been published. Our case is unique in terms of presence MGDA, PHPV, unilateral ROP like retinopathy in a term infant with normal birth weight.

Case presentation

A 5-month-old girl, born at term with a birth weight of 3750 g, presented with anterior PHPV, MGDA and ROP like retinopathy. In order to prevent retinal detachment, she received 360 degree barrage laser photocoagulation at the edge of the optic disc excavation of the left eye. In the follow-up a month later, laser scars were found in her left fundus without other complications.

Conclusion

PHPV and MGDA with ROP like retinopathy in term and normal weight baby is rare. The peripheral avascular retinal area, caused by the dragging of the defected optic disc, might have been more vulnerable to the oxygen change after birth which resulted in ROP like retinopathy. High sensitivity to oxygen results in a series of changes such as upregulation of VEGF and IGF-1 may cause ROP-like retinopathy.
Congenital orbital teratoma: a case report with preservation of the globe and 18 years of follow-up
Authors: Tsoutsanis Panagiotis A. , Charonis George C.
Published: December 2021

Background

Congenital orbital teratomas are extremely rare, usually benign neoplasms, comprised of cells originating from all three germ cell layers. Clinically the tumor appears solid, most of the times is intraconal and presents as a rapidly growing mass leading to a massive unilateral axial proptosis, chemosis, exposure keratopathy, markedly distended eyelids and often, loss of vision. To prevent these complications, tumor excision usually involves enucleation or even orbital exenteration.

Case presentation

We report a case of a 1-day old infant who presented with dramatic proptosis at birth due to a true congenital orbital teratoma. We describe the clinical findings, the preoperative neuroimaging, the surgical management which included complete tumor resection with preservation of the globe to allow for optimal orbital growth, the histopathological evaluation, and the clinical course during 18 years of follow up.

Conclusion

Every effort to salvage the globe should be made to achieve the best possible orbito-facial development. Furthermore, the value of prompt surgical management with a less invasive transconjunctival globe sparing procedure can be appreciated in our case.
Acute liver failure caused by Amanita verna: a case series and review of the literature
Authors: Wu Jianlong , Gong Xueyi , Hu Zemin , Sun Qiang
Published: December 2021

Background

Amanita verna is one of the most harmful wild fungi in China. Amanita verna poisoning occurs every year, and the mortality is as high as 50%. However, its clinical manifestations are complex and diverse.

Case presentation

In March 2019, three patients took a large amount of Amanita, and one of them received liver transplantation in Zhongshan hospital, Sun Yat-sen University. All patients had vomiting and diarrhea 8–12 h after eating wild mushrooms (Amanita). The patients were initially diagnosed with Amanita poisoning. One case (case 3) was complicated and diagnosed as mushroom poisoning (fatal Amanita), toxic hepatitis, acute liver failure, toxic encephalopathy, hemorrhagic colitis, toxic myocarditis, disseminated intravascular coagulation (DIC) and pregnancy. The general clinical data of all patients were recorded, who received early treatment such as hemodialysis, artificial liver plasma exchange, hormone shock and anti-infection. One case (case 1) recovered smoothly after liver transplantation, and the indexes of liver, kidney, coagulation function and infection were improved. The other two cases died of intracerebral hemorrhage.

Conclusion

Liver transplantation is an effective method for the treatment of acute liver failure caused by mushroom poisoning and can improve the survival rate of patients with toxic liver failure.
Self-administered succus entericus reinfusion before ileostomy closure improves short-term outcomes
Authors: Liu Zhen , Fang Liang , Lv Liang , Niu Zhaojian , Hou Litao , Chen Dong , Zhou Yanbing , Guo Dong
Published: December 2021

Objective

The study aims to assess whether reinfusion of succus entericus prior to ileostomy closure can decrease postoperative length of stay and ameliorate low anterior resection score.

Methods

This study is a retrospective analysis based on prospectively collected data. Patients were screened from May 2016 to November 2019. A total of 30 patients who underwent reinfusion with succus entericus (SER) were enrolled in the SER group and 42 patients without SER were enrolled in the non-SER group.

Results

There was no significant difference in the incidence of postoperative ileus between succus entericus reinfusion (SER) group and the control group. Time to first passage of flatus or stool after surgery in the SER group (27.9 ± 6.02 h) is significantly shorter than the control group (32.3 ± 6.26, hours p = 0.004). Compared with the control group (5.52 (4.0–7.0) days), postoperative length of stay in the SER group was 4.90 (3.0–7.0)days (p = 0.009). As for low anterior resection score(LARS), the SER group had a lower score 1 week after discharge than the control group (p = 0.034). However, 1 month after discharge, the LARS in the two groups had no significant difference.

Conclusions

Self-administered succus entericus reinfusion is a feasible prehabilitation management for outpatients and can improve better outcomes. Compared with non-reinfusion group, succus enterius reinfusion group displays significantly shorter time for gastrointestinal function recovery and postoperative hospital stay without increasing complication, and it can bring better quality of life in a short term.
Age at menarche, age at menopause, reproductive years and risk of fatal stroke occurrence among Chinese women: the Guangzhou Biobank Cohort Study
Authors: Hu Zhi-bing , Lu Ze-xiong , Zhu Feng
Published: December 2021

Background

The relationship between women’s reproductive characteristics and stroke events is unclear. We aimed to investigate age at menarche, age at menopause and number of reproductive years in relation to fatal stroke occurrence in the Guangzhou Biobank Cohort Study.

Methods

In total, 16,504 postmenopausal women without stroke, heart disease or a cancer history at baseline were included and followed up for a median of 12.0 years. After review of available records, 222 stroke deaths were recorded. Cox proportional hazards regression was used to assess the associations between the risk of fatal stroke occurrence and age at menarche, age at menopause and number of reproductive years.

Results

In the whole cohort, compared with those aged 15 years at menarche, an increased risk of fatal stroke among women at menarche showed respectively in those aged 12 years (aHR (adjusted hazard ratio) = 1.86, 95% confidence interval (CI) 0.96–3.60), aged 13 years (aHR = 1.69, 95% CI 0.98–2.92), aged 17 years (aHR = 1.83, 95% CI 1.10–3.05) and aged ≥ 18 years (aHR = 1.66, 95% CI 1.03–2.70), wherein the associations revealed an atypically U-shaped; similar U-shaped association to the cohort of postmenopausal women born before 1940 released a range of incremental risks of fatal stroke in women at menarche aged ≤ 12 years (aHR = 3.68, 95% CI 1.68–8.05), aged 13 years (aHR = 2.11, 95% CI 1.02–4.34), aged 14 years (aHR = 2.07, 95% CI 1.04), aged 17 years (aHR = 2.30, 95% CI 1.20–4.39) and aged 18 years (aHR = 2.50, 95% CI 1.37–4.57), respectively. Compared with menopausal women aged 51–52 years, those aged < 43 years at menopause had an increased risk for fatal stroke among postmenopausal women born in and after 1940 (aHR = 1.64, 95% CI 0.97–2.78) and postmenopausal women born before 1940 (aHR = 1.97, 95% CI 1.05–3.69). Additionally, compared with those with 32–34 reproductive years, women with ≤ 28 reproductive years had an increased risk for fatal stroke in the whole cohort (aHR = 1.91, 95% CI 1.28–2.86) and the cohort of postmenopausal women born before 1940 (aHR = 1.79, 95% CI 1.15–2.80).

Conclusions

Younger and older age at menarche, younger age at menopause and fewer reproductive ages were related to an increased risk of fatal stroke in postmenopausal women.
Group-based physical activity interventions for postpartum women with children aged 0–5 years old: a systematic review of randomized controlled trials
Authors: Peralta L. R. , Cotton W. G. , Dudley D. A. , Hardy L. L. , Yager Z. , Prichard I.
Published: December 2021

Background

It is estimated that less than one third of women (28%) worldwide, are not sufficiently active, and there is evidence indicating physical activity (PA) participation is lower during pregnancy and the postpartum period. Despite the importance of educating and encouraging postpartum women to engage in PA, existing systematic reviews have only focused on examining the impact of individually tailored PA interventions and on specific postpartum populations such as women who are inactive (i.e., do not meet PA recommendations) or women at risk of gestational diabetes mellitus or postnatal depression. This review aims to fill this gap by examining the impact of group-based PA interventions on postpartum women’s PA levels or other health behavior outcomes.

Methods

A systematic literature search was conducted using four electronic databases (MEDLINE, CINAHL, EMBASE and PsychInfo) of published studies between 1st January 2000 and 31st October 2020. Studies were included if they targeted postpartum women with no current health conditions, had children aged 0–5 years, and engaged postpartum women in a group-based PA program that reported PA or other health behavior outcomes. Out of a total of 1091 articles that were initially identified, six were included.

Results

Group-based PA interventions were moderately successful in changing or increasing postpartum women’s self-reported PA levels and psychological wellbeing in the first 2 years of their offspring’s life. Overall, group-based PA interventions were not successful in changing or increasing postpartum women’s objectively measured PA levels, but only one study objectively measured postpartum women’s PA levels. Narrative synthesis highlights the heterogeneity of the outcomes and methodologies used, and the low to medium risk of bias in the included studies.

Conclusion

To strengthen the evidence-base for group-based PA programs with postpartum women there is an on-going need for more rigorous randomised controlled trials of appropriate length (at least 3 months in duration) with an adequate dose of group-based PA sessions per week (to meet PA guidelines), and that utilise objective measures of PA. In addition, future PA interventions for this population should include, at the very least, fidelity and process data to capture the characteristics or design features that appeal most to postpartum women.
Ethical considerations for HIV remission clinical research involving participants diagnosed during acute HIV infection
Authors: Gilbertson Adam , Tucker Joseph D. , Dubé Karine , Dijkstra Maartje , Rennie Stuart
Published: December 2021

HIV remission clinical researchers are increasingly seeking study participants who are diagnosed and treated during acute HIV infection—the brief period between infection and the point when the body creates detectable HIV antibodies. This earliest stage of infection is often marked by flu-like illness and may be an especially tumultuous period of confusion, guilt, anger, and uncertainty. Such experiences may present added ethical challenges for HIV research recruitment, participation, and retention. The purpose of this paper is to identify potential ethical challenges associated with involving acutely diagnosed people living with HIV in remission research and considerations for how to mitigate them. We identify three domains of potential ethical concern for clinicians, researchers, and ethics committee members to consider: 1) Recruitment and informed consent; (2) Transmission risks and partner protection; and (3) Ancillary and continuing care. We discuss each of these domains with the aim of inspiring further work to advance the ethical conduct of HIV remission research. For example, experiences of confusion and uncertainty regarding illness and diagnosis during acute HIV infection may complicate informed consent procedures in studies that seek to recruit directly after diagnosis. To address this, it may be appropriate to use staged re-consent procedures or comprehension assessment. Responsible conduct of research requires a broad understanding of acute HIV infection that encompasses its biomedical, psychological, social, and behavioral dimensions. We argue that the lived experience of acute HIV infection may introduce ethical concerns that researchers and reviewers should address during study design and ethical approval.
How to reveal disguised paternalism: version 2.0
Authors: Lynøe Niels , Engström Ingemar , Juth Niklas
Published: December 2021

Background

We aim to further develop an index for detecting disguised paternalism, which might influence physicians’ evaluations of whether or not a patient is decision-competent at the end of life. Disguised paternalism can be actualized when physicians transform hard paternalism into soft paternalism by questioning the patient’s decision-making competence.

Methods

A previously presented index, based on a cross-sectional study, was further developed to make it possible to distinguish between high and low degrees of disguised paternalism using the average index of the whole sample. We recalculated the results from a 2007 study for comparison to a new study conducted in 2020. Both studies are about physicians’ attitudes towards, and arguments for or against, physician-assisted suicide.

Results

The 2020 study showed that geriatricians, palliativists, and middle-aged physicians (46–60 years old) had indices indicating disguised paternalism, in contrast with the results from the 2007 study, which showed that all specialties (apart from GPs and surgeons) had indices indicating high degrees of disguised paternalism.

Conclusions

The proposed index for identifying disguised paternalism reflects the attitude of a group towards physician assisted suicide. The indices make it possible to compare the various medical specialties and age groups from the 2007 study with the 2020 study. Because disguised paternalism might have clinical consequences for the rights of competent patients to participate in decision-making, it is important to reveal disguised hard paternalism, which could masquerade as soft paternalism and thereby manifest in practice. Methods for improving measures of disguised paternalism are worthy of further development.
ECG signal classification based on deep CNN and BiLSTM
Authors: Cheng Jinyong , Zou Qingxu , Zhao Yunxiang
Published: December 2021

Background

Currently, cardiovascular disease has become a major disease endangering human health, and the number of such patients is growing. Electrocardiogram (ECG) is an important basis for {medical doctors to diagnose the cardiovascular disease, which can truly reflect the health of the heart. In this context, the contradiction between the lack of medical resources and the surge in the number of patients has become increasingly prominent. The use of computer-aided diagnosis of cardiovascular disease has become particularly important, so the study of ECG automatic classification method has a strong practical significance.

Methods

This article proposes a new method for automatic identification and classification of ECG.We have developed a dense heart rhythm network that combines a 24-layer Deep Convolutional Neural Network (DCNN) and Bidirectional Long Short-Term Memory (BiLSTM) to deeply mine the hierarchical and time-sensitive features of ECG data. Three different sizes of convolution kernels (32, 64 and 128) are used to mine the detailed features of the ECG signal, and the original ECG is filtered using a combination of wavelet transform and median filtering to eliminate the influence of noise on the signal. A new loss function is proposed to control the fluctuation of loss during the training process, and convergence mapping of the tan function in the range of 0–1 is employed to better reflect the model training loss and correct the optimization direction in time.

Results

We applied the dataset provided by the 2017 PhysioNet/CINC challenge for verification. The experiment adopted ten-fold cross validation,and obtained an accuracy rate of 89.3$$\%$$%and an F1 score of 0.891.

Conclusions

This article proposes its own method in the aspects of ECG data preprocessing, feature extraction and loss function design. Compared with the existing methods, this method improves the accuracy of automatic ECG classification and is helpful for clinical diagnosis and self-monitoring of atrial fibrillation.
Glucose starvation suppresses gastric cancer through targeting miR-216a-5p/Farnesyl-Diphosphate Farnesyltransferase 1 axis
Authors: Zhao Ruiyang , Cao Bo , Li Hanghang , Li Tian , Xu Xingming , Cui Hao , Deng Huan , Wei Bo
Published: December 2021

Background

Fasting mimic diet is an effect approach for gastric cancer (GC) treatment. Exploring mechanisms of glucose deprivation-mediated GC suppression is required to develop novel therapeutic regimens. Farnesyltransferase 1 (FDFT1), as a novel target in basic research, has been reported to regulate malignant progression in some types of cancer. However, biological functions of FDFT1 in GC are still unclear. This study focused on biological functions of FDFT1 in GC and the association between glucose starvation (GS) and FDFT1.

Methods

The data derived from the Kaplan–Meier Plotter database were collected to identify the relationship between survival time and FDFT1 expression levels of GC patients. Bioinformatic analysis was performed to explore the biological functions of FDFT1. The expression levels of targeted genes and microRNAs (miRNAs) were detected with immunohistochemistry, quantitative real-time PCR and western blot. Malignant behaviors were measured using cell counting, cell counting kit-8, 5-ethynyl-2-deoxyuridine, wound healing, invasion transwell assays in vitro and constructions of subcutaneous and lung-metastatic tumors in vivo. The glycolysis of GC cells was determined by a series of metabolites, including lactate acid, pyruvic acid, ATP production, rates of glucose uptake, extracellular acidification rate and oxygen consumption rate.

Results

FDFT1 was downregulated in GC and negatively correlated with pathological T stage, pathological TNM stage and cancer differentiation. High expression of FDFT1 also indicated better prognosis of GC patients. FDFT1 upregulation attenuated proliferation, migration and invasion of GC. miR-216a-5p was identified as a critical suppressor of FDFT1 expression and miR-216a-5p/FDFT1 axis regulated malignant behaviors and glycolysis of GC cells. GS suppressed malignant behaviors of GC by targeting miR-216a-5p/FDFT1 axis both in vitro and in vivo.

Conclusion

This study illustrated novel mechanisms by which GS effectively suppresses GC. FDFT1 may become a potential prognostic indicator and novel target of GC therapy.
Bio-assisted synthesis of bimetallic nanoparticles featuring antibacterial and photothermal properties for the removal of biofilms
Authors: Nudelman Roman , Gavriely Shira , Bychenko Darya , Barzilay Michal , Gulakhmedova Tamilla , Gazit Ehud , Richter Shachar
Published: December 2021

Biofilms are responsible for about considerable amounts of cases of bacterial infections in humans. They are considered a major threat to transplant and chronic wounds patients due to their highly resistant nature against antibacterial materials and due to the limited types of techniques that can be applied to remove them. Here we demonstrate a successful in-situ bio-assisted synthesis of dual functionality nanoparticles composed of Silver and Gold. This is done using a jellyfish-based scaffold, an antibacterial material as the templating host in the synthesis. We further explore the scaffold’s antibacterial and photothermal properties against various gram-negative and positive model bacteria with and without photo-induced heating at the Near-IR regime. We show that when the scaffold is loaded with these bimetallic nanoparticles, it exhibits dual functionality: Its photothermal capabilities help to disrupt and remove bacterial colonies and mature biofilms, and its antibacterial properties prevent the regrowth of new biofilms.

Graphical Abstract
Acidic microenvironment responsive polymeric MOF-based nanoparticles induce immunogenic cell death for combined cancer therapy
Authors: Zhang Xiaoli , Lu Yi , Jia Die , Qiu Wei , Ma Xianbin , Zhang Xingliang , Xu Zhigang , Wen Feiqiu
Published: December 2021

Background

The complex tumor microenvironment and non-targeting drugs limit the efficacy of clinical tumor therapy. For ensuring the accurate delivery and maximal effects of anticancer drugs, it is important to develop innovative drug delivery system based on nano-strategies.

Result

In this study, an intracellular acidity-responsive polymeric metal organic framework nanoparticle (denoted as DIMP) has been constructed, which can co-deliver the chemotherapy agent of doxorubicin (DOX) and phototherapy agent of indocyanine green (ICG) for breast carcinoma theranostics. Specifically, DIMP possesses a suitable and stable nanometer size and can respond to the acidic microenvironment in cells, thus precisely delivering drugs into target tumor sites and igniting the biological reactions towards cell apoptosis. Following in vivo and in vitro results showed that DIMP could be effectively accumulated in tumor sites and induced powerful immunogenic cell death (ICD) effect.

Conclusion

The designed DIMP displayed its effectiveness in combined photo-chemotherapy with auxiliary of ICD effect under a multimodal imaging monitor. Thus, the present MOF-based strategy may offer a potential paradigm for designing drug-delivery system for image-guided synergistic tumor therapy.

Graphical Abstract
The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006
Authors: Li Song , Zhao Chu-Jin , Hua Hong-Li , Deng Yu-Qin , Tao Ze-Zhang
Published: December 2021

Background

The relationship between allergies and sinusitis, though extensively studied, remains poorly defined. While several studies proposed a cause-and-effect relationship between allergy and chronic sinusitis, several others reported the lack of any existing association. This study aimed to investigate the relationship between allergy and sinusitis.

Methods

We conducted a cross-sectional study using a representative sample of the US population from the National Health and Nutrition Examination Survey 2005‒2006 (n  = 7244). A self-reported allergy questionnaire and total and allergen-specific IgE levels were used for analysis. Participants were divided into positive and negative allergy symptoms groups (PAS, NAS, respectively) to eliminate the influence of allergy symptoms on the apparent incidence of sinusitis. Pearson’s chi-square test and the linear regression analysis using Durbin Watson test were used for statistical analysis.

Results

Sinusitis incidence in the PAS group (22.4%; 521/2327) was significantly higher than that in the NAS group (7.1%; 348/4917) [odds ratios (OR)  = 3.788, 95% confidence interval (CI) 3.272‒4.384, P  < 0.001]. sinusitis incidence in non-sensitized and sensitized groups was not statistically different. After controlling for allergy symptoms, there was a negative correlation between sensitization status and the occurrence of sinusitis in the PAS group (OR  = 1.407, 95% CI 1.156‒1.711, P  < 0.01). Increase in serum total IgE levels correlated with decrease in incidence of sinusitis in both PAS and NAS groups. sinusitis incidence was significantly reduced in the PAS group in participants sensitized to allergens such as cockroaches, ragweed, ryegrass, Bermuda grass, oak, birch, and thistle.

Conclusion

Allergy is related to sinusitis incidence. It is likely that sensitization status could reduce the incidence of sinusitis, albeit in an antigen-specific manner.
Exosomes originating from infection with the cytoplasmic single-stranded RNA virus Rift Valley fever virus (RVFV) protect recipient cells by inducing RIG-I mediated IFN-B response that leads to activation of autophagy
Authors: Alem Farhang , Olanrewaju Adeyemi A. , Omole Samson , Hobbs Heather E. , Ahsan Noor , Matulis Graham , Brantner Christine A. , Zhou Weidong , Petricoin Emanuel F. , Liotta Lance A. , Caputi Massimo , Bavari Sina , Wu Yuntao , Kashanchi Fatah , Hakami Ramin M.
Published: December 2021

Background

Although multiple studies have demonstrated a role for exosomes during virus infections, our understanding of the mechanisms by which exosome exchange regulates immune response during viral infections and affects viral pathogenesis is still in its infancy. In particular, very little is known for cytoplasmic single-stranded RNA viruses such as SARS-CoV-2 and Rift Valley fever virus (RVFV). We have used RVFV infection as a model for cytoplasmic single-stranded RNA viruses to address this gap in knowledge. RVFV is a highly pathogenic agent that causes RVF, a zoonotic disease for which no effective therapeutic or approved human vaccine exist.

Results

We show here that exosomes released from cells infected with RVFV (designated as EXi-RVFV) serve a protective role for the host and provide a mechanistic model for these effects. Our results show that treatment of both naïve immune cells (U937 monocytes) and naïve non-immune cells (HSAECs) with EXi-RVFV induces a strong RIG-I dependent activation of IFN-B. We also demonstrate that this strong anti-viral response leads to activation of autophagy in treated cells and correlates with resistance to subsequent viral infection. Since we have shown that viral RNA genome is associated with EXi-RVFV, RIG-I activation might be mediated by the presence of packaged viral RNA sequences.

Conclusions

Using RVFV infection as a model for cytoplasmic single-stranded RNA viruses, our results show a novel mechanism of host protection by exosomes released from infected cells (EXi) whereby the EXi activate RIG-I to induce IFN-dependent activation of autophagy in naïve recipient cells including monocytes. Because monocytes serve as reservoirs for RVFV replication, this EXi-RVFV-induced activation of autophagy in monocytes may work to slow down or halt viral dissemination in the infected organism. These findings offer novel mechanistic insights that may aid in future development of effective vaccines or therapeutics, and that may be applicable for a better molecular understanding of how exosome release regulates innate immune response to other cytoplasmic single-stranded RNA viruses.
Charaterizations of 3D printed re-entrant pattern/aramid knit composite prepared by various tilting angles
Authors: Jung Imjoo , Kim Hyelim , Lee Sunhee
Published: December 2021

This study intended to compare and analyze the Poisson's ratio and mechanical properties of aramid knit (ARNT), 3D printed auxetic re-entrant pattern (3DP-RE), and 2 types of composite fabrics manufactured with ARNT and 3DP-RE. Specimens were manufactured by 3D printing the re-entrant pattern with a CFDM (conveyor fused deposition modeling) 3D printer and TPU (thermoplastic polyurethane) filament, combining with aramid knit in 2 ways. Then, Poisson's ratio, bending, compression, and tensile properties were tested. As a result of Poisson's ratio, 3DP-RE and its 2 types of composite fabric showed negative Poisson's ratio at all angles and deformed stable at 0° and 90° than the bias direction. The bending strength confirmed that the composite fabric showed a lower value. But, the strain at max bending strength was greater than a substrate fabric. At the compression properties, it has been confirmed that compression strength and toughness are improved when manufacturing composite fabrics. As a result of tensile properties, 3DP-RE and composite fabrics were significantly more initial modulus, elongation and toughness than ARNT and were shown to be the largest in gradient 90°. Therefore, it is confirmed that the performance is excellent when fabricated as a 3DP-RE/ARNT composite fabric, and based on the results of studies, we intend to use it as the basic data for composite fabrics of auxetic structure suitable for shoe uppers.
Socio and ethno-cultural embeddedness of transnational Nigerian immigrant entrepreneurs in Ghana
Authors: Antwi Bosiakoh Thomas , Obeng Bernard Acquah
Published: December 2021

Transnational Nigerian immigrant entrepreneurs have been in Ghana for a long time, operating by utilizing a wide range of resources available to them. Key among these resources are their own socio and ethno-cultural norms which have yet to be explored in the existing scholarship. We explore these patterns and norms in the articulation of transnational entrepreneurship among these immigrants in Ghana. We do this by relying on qualitative data gathered through in-depth interviews, observations and market conversations—with 41 Nigerian immigrant entrepreneurs in Accra, Kumasi, and Ashaiman. We argue that these transnational Nigerian immigrant entrepreneurs in Ghana are embedded in their own ‘socio and ethno-cultural heritage’. This argument is anchored in multiple logics. First is the notion of transnational entrepreneurial activity that is ethnically and culturally inspired. Secondly, these entrepreneurship activities are inextricably embedded in informality and intensely rely on informal power brokerage system. Thirdly, there is an embeddedness in the entrepreneurs’ own traditional apprenticeship system. These lines of socio and ethno-cultural embeddedness provide useful pathways for understanding not only the operations and future prospects but also the patterns of transnational (mixed) embeddedness of the Nigerian immigrant entrepreneurs in Ghana.
Macrophage activation syndrome in a patient with adult-onset Still’s disease following first COVID-19 vaccination with BNT162b2
Authors: Muench Frédéric , Krusche Martin , Sander Leif Erik , Rose Thomas , Burmester Gerd-Rüdiger , Schneider Udo
Published: December 2021

Background

Adult-onset Still’s disease (AOSD) is an autoinflammatory multi-systemic syndrome. Macrophage activation syndrome (MAS) is a potentially life-threatening complication of AOSD with a mortality rate of 10–20%. Especially viral infection is thought to be a common trigger for development of MAS. On the other hand, the occurrence of MAS following vaccinations is extremely rare and has been described in a few cases after measles or influenza vaccinations and more recently after ChAdOx1 nCoV-19 (COVID-19 viral vector vaccine, Oxford-AZ).

Case presentation

We report the case of a twenty-year-old female with adult-onset Still’s disease (AOSD), who developed a MAS six days after receiving her first COVID-19 vaccine dose of BNT162b2 (mRNA vaccine, BioNTech/Pfizer) with ferritin levels of 136,680 µg/l (ref.: 13–150 µg/l).

Conclusions

To the best of our knowledge, this is the first case report of development of MAS in a patient with preexisting AOSD after vaccination in general, and SARS-CoV-2 vaccination in particular. The new mRNA vaccines have generally shown a reassuring safety profile, but it has been shown that nucleic acids in general, including mRNA can act as pathogen-associated molecular patterns that activate toll-like receptors with extensive production of pro-inflammatory cytokines and further activation of immune cells. Proving an interferon 1 response in our patient directly after vaccination, we think that in this particular case the vaccination might have acted as trigger for the development of MAS. Even if it remains difficult to establish causality in the case of rare adverse events, especially in patients with autoimmune or autoinflammatory conditions, these complications are important to monitor and register, but do not at all diminish the overwhelming positive benefit-risk ratio of licensed COVID-19 vaccines.
Confidence Culture
Authors: Orgad Shani , Gill Rosalind
Published: December 2021

In Confidence Culture, Shani Orgad and Rosalind Gill argue that imperatives directed at women to “love your body” and “believe in yourself” imply that psychological blocks rather than entrenched social injustices hold women back. Interrogating the prominence of confidence in contemporary discourse about body image, workplace, relationships, motherhood, and international development, Orgad and Gill draw on Foucault’s notion of technologies of self to demonstrate how “confidence culture” demands of women near-constant introspection and vigilance in the service of self-improvement. They argue that while confidence messaging may feel good, it does not address structural and systemic oppression. Rather, confidence culture suggests that women—along with people of color, the disabled, and other marginalized groups—are responsible for their own conditions. Rejecting confidence culture’s remaking of feminism along individualistic and neoliberal lines, Orgad and Gill explore alternative articulations of feminism that go beyond the confidence imperative.
College Tuition and Income Inequality
Authors: Cai Zhifeng , Heathcote Jonathan
Published: December 2021

This paper evaluates the role of rising income inequality in explaining observed growth in college tuition. We develop a competitive model of the college market, in which college quality depends on instructional expenditure and the average ability of admitted students. An innovative feature of our model is that it allows for a continuous distribution of college quality. We find that observed increases in US income inequality can explain more than half of the observed rise in average net tuition since 1990 and that rising income inequality has also depressed college attendance. (JEL D31, I22, I23, I24)
Imperfect Competition, Compensating Differentials, and Rent Sharing in the US Labor Market
Authors: Lamadon Thibaut , Mogstad Magne , Setzler Bradley
Published: December 2021

We quantify the importance of imperfect competition in the US labor market by estimating the size of labor market rents earned by American firms and workers. We construct a matched employer-employee panel dataset by combining the universe of US business and worker tax records for the period 2001–2015. Using this panel data, we identify and estimate an equilibrium model of the labor market with two-sided heterogeneity where workers view firms as imperfect substitutes because of heterogeneous preferences over nonwage job characteristics. The model allows us to draw inference about imperfect competition, worker sorting, compensating differentials, and rent sharing. (JEL D24, H24, H25, J22, J24, J31, J42)
Consumption Response to Credit Expansions: Evidence from Experimental Assignment of 45,307 Credit Lines
Authors: Aydin Deniz
Published: December 2021

In a field experiment that constructs a randomized credit limit shock, participants borrow to spend 11 cents on the dollar in the first quarter and 28 cents by the third year. Effects extend to those far from the limit, those who had the new limits as available credit, and those with a liquid asset buffer. In the short-run, flexible and installment contracts are used in tandem, with unconstrained using installments more. Long-run borrowing is predominantly using installments. Near limits, participants borrow when credit expands but save out of constraints when limits are tight. Findings support a buffer-stock interpretation emphasizing precautionary saving. (JEL C93, E21, G21, G51, O12, O16)
Employment Structure and the Rise of the Modern Tax System
Authors: Jensen Anders
Published: December 2021

This paper builds a new microdatabase that covers 100 countries at all income levels and long-run time series in the United States (1870–2010) and Mexico ( 1960–2010) to document how the modern tax system arises over development. I establish a new set of stylized facts, which show that the income tax exemption threshold decreases in the income distribution as a country develops, tracking growth in the employee share of employment that occurs gradually further down the income distribution. Additional evidence supports the interpretation that the rise in third-party covered income through increases in employee share drives expansions of the income tax base over development. (JEL D31, H23, H24, H71, J22, J23, N40)
Human animal and the dynamic of becoming humans.
Authors: Zavala Olalde Juan Carlos
Published: December 2021

This essay shows an organization of the explanation of the human being as a humanized animal. It is based on explaining the human tendency to educate and generate human beings as the peculiar emergence of the human being. To explain the human quality, it addresses the understanding of human development that is humanized in society, that builds a reality of being human in the culture, and to become human as an aim. Humanization comes as the opposite of animality in whose dynamics the human being is. Several examples of how human beings act in making and becoming human are presented. We propose a process and how important it is to respond to; what are human beings, in a world like the current one that does not have a firm foundation to build knowledge
Imposing Contiguity Constraints in Political Districting Models
Authors: Validi Hamidreza , Buchanan Austin , Lykhovyd Eugene
Published: December 2021

For nearly 60 years, operations research techniques have assisted in the creation of political districting plans, beginning with an integer programming model. This model, which seeks compactness as its objective, tends to generate districts that are contiguous, or nearly so, but provides no guarantee of contiguity. In the paper “Imposing contiguity constraints in political districting models” by Hamidreza Validi, Austin Buchanan, and Eugene Lykhovyd, the authors consider and analyze four different contiguity models (two old and two new). Their computer implementation can handle redistricting instances as large as Indiana (1,511 census tracts). Their fastest approach uses a branch-and-cut algorithm, where contiguity constraints are added in a callback. Critically, many variables can be fixed to zero a priori by Lagrangian arguments. All test instances and source code are publicly available.
An Optimal Approximation for Submodular Maximization Under a Matroid Constraint in the Adaptive Complexity Model
Authors: Balkanski Eric , Rubinstein Aviad , Singer Yaron
Published: December 2021

An Exponentially Faster Algorithm for Submodular Maximization Under a Matroid Constraint

This paper studies the problem of submodular maximization under a matroid constraint. It is known since the 1970s that the greedy algorithm obtains a constant-factor approximation guarantee for this problem. Twelve years ago, a breakthrough result by Vondrák obtained the optimal 1 − 1/e approximation. Previous algorithms for this fundamental problem all have linear parallel runtime, which was considered impossible to accelerate until recently. The main contribution of this paper is a novel algorithm that provides an exponential speedup in the parallel runtime of submodular maximization under a matroid constraint, without loss in the approximation guarantee.
A Decade of Value Education Model: A Bibliometric Study of Scopus Database in 2011-2020
Authors: Supriadi Udin , Supriyadi Tedi , Abdussalam Aam , Rahman Aam Ali
Published: December 2021

This bibliometric study aims to map the value education model research to provide direction for future research, especially in education and teaching. It is essential because value is the core of education. After all, in addition to opening the window of knowledge, education also has a role in transferring values for internalizing them in the education model. Therefore, conducting studies related to the concept and model of value education is essential for an educator. The focus of this study is to examine the bibliography related to the value education model based on the Scopus database in the period 2011-2020. This research took four stages; first: using Publish or Perish application to search articles from Scopus database. Second, performing filter by setting bibliographic criteria to be analyzed. Third, checking and completing articles' metadata through the EndNote reference manager application. Fourth, perform bibliometric analysis through the VOSviewer application. Through these four stages, seven analyses were explored; the trend of publications related to the value education model, analysis of the keywords used, collaboration of authors, citation patterns, institutions, and countries that were contributors to the study of the value education model, and abstract analysis. The results of this exploration conclude that there is a tendency for academics to pay less attention to the value education model when viewed from the number of publications related to the topic. The contribution of this research can be expected to provide direction for other researchers in conducting research and development related to educational models.
Restaurante Mata Nativa: Adaptação ou Oportunidade em Tempos de Pandemia da Covid-19
Authors: Nascimento Cassio Andre Bayma do , Behling Gustavo , Tutida Alessandra , Pereira Erick , Lana Jailson
Published: December 2021

Este caso para ensino relata a história do Restaurante Mata Nativa.  Tradicional no atendimento à la carte e na integração com a natureza como diferencial competitivo, a trajetória de 15 anos do restaurante evidencia como os processos de desenvolvimento das capacidades de aquisição, assimilação, transformação e aplicação do conhecimento foram essenciais no desenvolvimento do empreendimento e em especial para superação da crise causada pela pandemia da Covid19. Recomenda-se a aplicação deste caso em cursos de Administração, nos níveis de pós-graduação lato sensu ou stricto sensu, em disciplinas de empreendedorismo ou estratégias organizacionais. Objetiva-se que os alunos possam refletir criticamente sobre o processo de desenvolvimento de capacidades para geração de vantagens competitivas e de desempenho organizacional.
Quanto Tempo Destinar para as Discussões ao Ensinar com Casos para Ensino?
Authors: Beal Partyka Raul , De Lima Carlos Eduardo , Lana Jailson
Published: December 2021

A Harvard Business School (HBS) introduziu o aprendizado baseado em problemas usando casos em apresentações e assim emergiu o método de caso HBS. Posteriormente, o método tornou-se estratégia de ensino nas principais escolas de negócio do mundo. Um dos principais elementos para a execução da aula baseada no ensino com casos para ensino é o tempo, tanto para realização das atividades quanto pela discussão entre os discentes e o docente. O tempo estipulado é crucial para conectar os objetivos do caso com a discussão em classe. Diante dessa peculiaridade, este ensaio avança por discutir e evidenciar quanto tempo os professores devem permitir para discussão ao ensinar com casos para ensino. É possível afirmar que a fase de discussão é essencial quando se trata de ensinar com casos e são providos exemplos do uso de metade da duração total da aula para discussão. O estudo também mostra que é uma área que precisa de mais investigação, uma vez que a quantidade certa de tempo para a discussão com casos para ensino ainda não foi encontrada.
Editorial
Authors: Kondo Edson Kenji
Published: December 2021

Nessa 3ª edição destacamos publicações sobre Casos para Ensino no ensino e aprendizagem em Administração. Para isso, contamos com editores gabaritados e reconhecidos nessa temática. Sob a coordenação do Prof. Edson Kenji Kondo (FGV), PhD pela Harvard University, e membro da associação de ex-alunos dessa prestigiosa universidade, referência mundial em Casos para Ensino, os professores Anielson Barbosa da Silva (UFPB), Coordenador do Núcleo de Estudos em Aprendizagem e Conhecimento, ex-diretor da ANPAD e umas das principais referências na área de Ensino e Pesquisa do país, Prof. Gaspar Giacomini (ESPM), coordenador nacional da Central de Cases em sua instituição de ensino e Profª Anete Alberton (UNIVALI), com atuação com casos de ensino em periódicos como a TAC - Revista de Tecnologias de Administração e Contabilidade da ANPAD e a RAC - Revista de Administração Contemporânea, além da liderança nesse tema na divisão EPQ/ANPAD.
3D particle tracking using transport of intensity equation (TIE)
Authors: Rezaei Nadim , Aakhte Mostafa , Charsooghi Mohammad , Borzouei Hadi , Akhlaghi Ehsan A.
Published: December 2021

This article presents a simple and high-speed approach for tracking colloidal spheres in three dimensions. The method uses the curvature of the wavefront as determined by the transport of intensity equation (TIE) technique. Due to the fact that the TIE is applicable under partially coherent light, our technique is fully compatible with standard bright field microscopes, requiring no demanding environmental stability requirements or restrictions on the noise produced by related laser speckles. The method was validated experimentally to determine the sedimentation and diffusion coefficients of two different sizes of microspheres, 20 and 3 microns. The 3D position of the microspheres was calculated with an accuracy greater than 350 nm. Moreover, we examined the calculated 3D positions to determine the parameters of the microsphere interaction with its surrounding media, such as the sedimentation and diffusion coefficients. The results show that the measured sedimentation and diffusion of the microspheres have a good agreement with predicted values of about 2% and 10%, respectively, demonstrating the robustness of our proposed method.