bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunotherapy in Hodgkin lymphoma
Authors: Kuruvilla John
Published: July 2023

Classical Hodgkin lymphoma (cHL) is a very curable form of cancer for the majority of patients that receive standard primary therapy. Many patients will have a second opportunity for cure at the time of first progression using approaches that incorporate high dose chemotherapy and autologous stem cell transplant (ASCT). In the non-curative setting, a group of patients (including patients with advanced age and comorbidities precluding standard therapy approaches and those with lymphoma that persists despite these treatments) will be treated with palliative intent. While these patients have had limited options in the past, novel therapies have rapidly become the standard of care in this setting. Antibodies targeting CD30 (the antibody drug conjugate brentuximab vedotin [BV]) and the immune checkpoint through PD1 (nivolumab and pembrolizumab) have now become standard approved treatments for patients beyond second-line treatment. The biology of PD1 appears particularly relevant in cHL, providing a strong clinical rationale for evaluating these agents in this malignancy. Clinicians in Canada now have several choices when making treatment decisions in patients with relapsed or refractory cHL (RR-cHL). Prospective trials are now determining the role of anti-PD1 antibodies in the curative setting.
Tailoring therapy in Waldenström Macroglobulinemia
Authors: Villa Diego
Published: July 2023

Waldenström Macroglobulinemia (WM) is a mature B-cell neoplasm categorized as a lymphoplasmacytic lymphoma (LPL) with monoclonal immunoglobulin M (IgM) production. WM comprises a spectrum of clinical manifestations related to (a) excessive infiltration of the bone marrow and/or other organs (lymph nodes, spleen, extranodal organs) by the LPL infiltrate, and (b) the impact of excess IgM on the circulatory and immune systems, and end organs. The latter includes serum hyperviscosity, infection related to suppression of other immunoglobulins, autoimmune cytopenias, cryoglobulinemia, production of anti-myelin-associated glycoprotein antibodies leading to peripheral neuropathy, and occasionally AL amyloidosis with end-organ deposition.
Multiple myeloma management: What comes after lenalidomide-based therapy?
Authors: Louzada Martha
Published: July 2023

Over the past two decades a myriad of new combination strategies and  therapeutic agents for the treatment of multiple myeloma (MM) have been developed. Novel drug classes such as proteasome inhibitors, immunomodulatory drugs and monoclonal antibodies have demonstrated very promising efficacy outcomes related to survival endpoints and improvements in quality of life for myeloma patients.
Chimeric antigen receptor T-cell therapy for relapsed and refractory large B-cell lymphoma
Authors: Elsawy Mahmoud
Published: July 2023

Comprising approximately 40% of diagnoses, lymphoma is the most common hematological malignancy in Canada, and 80% of lymphoma cases are non-Hodgkin lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) accounts for approximately 30% of new NHL cases in Canada. First-line treatment with standard of care chemoimmunotherapy consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) results in a cure in approximately 60–70% of patients. Nevertheless, 30–40% of patients will experience relapse of their disease or are refractory to first-line therapy.

Among those patients with relapsed or refractory DLBCL (R/R DLBCL), about 10–15% will exhibit primary refractory disease with either stable or progressive disease despite first-line therapy, while 20–25% will experience relapse after an initial response to treatment. Most relapses will occur within 2–3 years following initial treatment. For these patients, the standard approach is salvage chemotherapy followed by high-dose chemotherapy and autologous stem cell transplantation (ASCT) for those who meet the eligibility criteria and have chemosensitive disease.
Treatment options for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) patients
Authors: Foley Ronan , Owen Carolyn , Tabchi Samer , Razavi Ghazaleh
Published: July 2023

Approximately 40% of Diffuse large B cell lymphoma (DLBCL) patients relapse or do not respond to first line therapy. Deciding whether to pursue intensive therapies in these patients is complex, given the limited therapeutic access landscape for R/R DLCBL patients, as well as the risk of serious adverse events. Emerging therapies open up new possibilities.
Updates in the treatment of mantle cell lymphoma: A Canadian expert framework
Authors: Villa Diego , Kansara Roopesh , Lemieux Christopher , Kuruvilla John
Published: July 2023

Mantle cell lymphoma (MCL) is a B cell Non-Hodgkin Lymphoma that develops in the mantle zone of the lymph node. It is more common in men and is usually diagnosed at an advanced stage with involvement of lymph nodes, bone marrow, and potentially the gastrointestinal tract. MCL accounts for 5–10% of all new NHL cases per year in Canada, which is estimated at 11,400 for 2022. While most patients respond to initial treatment, relapses occur early and MCL generally shows a variable response to subsequent treatments, often with limited duration of benefit. Two main subtypes of MCL can be distinguished that arise from in situ MCL lesions. The most common subtype, classic MCL, arises from these cells with limited or no immunoglobulin heavy chain variable region (IGHV) mutations. Cells from this subtype express SOX11, are genetically unstable, and have naïve B cell-like characteristics. Classic MCL is more often nodal and extranodal and may eventually progress to aggressive blastoid or pleomorphic MCL. The other subtype, leukemic non-nodal MCL, arises from cells that have undergone IGHV somatic hypermutations, do not express SOX11, and exhibit characteristics of memory B cells. This subtype can have an indolent clinical behavior for a long time, often several years, but frequently acquires TP53 and other mutations and progresses to a more aggressive subtype. Treatment options have expanded significantly over the past decades, with improvements in both overall survival (OS) and progression-free survival (PFS) compared to earlier treatment eras. This Canadian expert framework aims to discuss the management considerations for patients with MCL, and will present both front-line treatment options as well as those for relapsed and refractory disease.
A review of the mechanism of action, safety, and efficacy of selinexor in multiple myeloma
Authors: Chen Christine , Neri Paola
Published: July 2023

In recent years, the armamentarium of routinely available treatments for relapsed and/or refractory multiple myeloma (RRMM) in Canada has dramatically expanded, but treatment gaps still exist. In early relapse (1-3 prior lines), monoclonal antibody (mAb) combinations on a backbone of lenalidomide or bortezomib (e.g. DRd, DVd) have been the mainstay, with combinations building on second generation backbones such as pomalidomide and carfilzomib (e.g. PCd, PVd, Kd) largely reserved for later relapse (after 2 prior lines). However, the increasing use of multi-class drug combinations in the frontline (e.g. DRd, RVd) and a shift towards ongoing therapy until progression, renders patients heavily drug-exposed and refractory at time of early relapse, needful of treatments with novel mechanisms of action. Selinexor is poised to fill an unmet need with a unique, non-overlapping mechanism of action to other available agents. XPOVIO® (selinexor) is indicated in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. SVd received Health Canada approval May 31, 2022. This review will present data on selinexor’s mechanism of action, efficacy in combination with dexamethasone and bortezomib (Sd, SVd), dosing and scheduling, as well as the management of its common and distinct toxicities.
STUDI DEVIASI PENERAPAN ASPEK HUKUM PENGADAAN KONSTRUKSI
Authors: Erdin Fahlefi  , Akhmad Suraji  , Albani Musyafa
Published: July 2023

In construction procurement in Indonesia there are still deviations in the tender process. The deviation is caused by an opportunity during the construction bidding process.  The service providers are mutually looking for opportunities to seek personal or group benefits or from the working group that makes these deviations. This causes state losses due to deviations in the construction bidding process. This research was conducted by collecting data from institutions that have the authority to decide whether or not deviations occur in the auction process. The institution authorized to decide whether or not a deviation occurs is the Commission for the Supervision of Business Competition of the Republic of Indonesia (KPPU RI). This study uses a questionnaire to find out how much the causes and impacts on state losses are caused by deviations in the auction process and uses the Probability and Impact Matrix method to determine the level of implication values of the causes and impacts of deviations in each case using a case base analysis approach. The results obtained based on the decision are as many as 12 types of deviation based on the case decision. The impact of deviations that occur in construction procurement is material and immaterial losses. The causes of deviation in construction procurement are caused by four factors, namely the factor of wanting to obtain personal or group benefits, opportunities, pressure and business climate. The most contributing factor to the occurrence of deviation is the combined conspiracy and vertical conspiracy resulting in a value of 11.38%.
Dissolving Microneedle Patches as Vaccine Delivery Platforms
Authors: Arshad Muhammad Sohail , Nazari Kazem , Rana Sadia Jafar , Zafar Saman , Uzair Muhammad , Ahmad Zeeshan
Published: July 2023

Microneedle (MN) patches overcome the drawbacks associated with parenteral route (risk of needle-prick injury, costly supervised administration, production of biohazardous waste) and deliver vaccines transcutaneously into general circulation. This study aimed to summarise three case studies relating to MN patch mediated vaccine delivery. Bacillus Calmette–Guérin (BCG), tetanus toxoid (TT) and rabies vaccine loaded patches were prepared using sodium alginate (SA), polyvinyl pyrollidone (PVP)/carboxymethyl cellulose (CMC) and PVP/hyaluronic acid (HA), respectively. MNs were evaluated for morphology, folding endurance, swelling and insertion ability. In-vivo immunogenic activity was assessed by recording several parameters e.g., immunoglobulin G (IgG), interferon gamma (IFN-γ), T-cell (CD4+ and CD8+) and rabies virus specific antibody count following MN patch application. MNs, displaying sharp tips and uniform surface, showed a folding endurance and swelling of ≥200 and ~70%, respectively indicating integrity and fluid uptake ability. MNs successfully penetrated into the skin simulant parafilm. MNs treated groups exhibited a significant increase in the IgG, IFN-γ, CD4+, CD8+, rabies virus specific antibody counts when compared to the control (untreated) groups and the results were comparable with standard intramuscular injection. Thus, MN patches can be used for transcutaneous vaccine delivery.
THEDES as a drug product intermediate for improved melt-extrusion processibility of thermally labile active ingredients
Authors: Abdelquader Magdy Mahmoud , Li Shu , Andrews Gavin Paul , Jones David
Published: July 2023

Hot melt extrusion (HME) is extensively employed in the pharmaceutical industry, but its utilization of heat raises concerns over drugs’ thermal stability. Strategies to improve stability and processibility of thermolabile materials via salt formation and co-crystals engineering are found in the literature. In this work, it was attempted to use therapeutic deep eutectic solvents (THEDES) as a mean to achieve improved drug thermal stability through the formation of a charge-assisted strong hydrogen boding network. Thermogravimetric studies on THEDES formed using a thermolabile drug, lidocaine, with different non-steroidal anti-inflammatory agents (NSAIDs) were employed to test this hypothesis. The resulted three THEDESs in this study were all tested to be more thermally stable than the corresponding parent compounds, confirming the stabilizing effect from the THEDES bonding network. This investigation reintroduces THEDES as a drug product intermediate with improved processibility for HME.  
Modulation of bacterial infection and inflammation by release of lactide from a silicone elastomer device
Authors: Huang Kaifeng
Published: July 2023

The aim of this project is to assess the anti-bacterial and anti-inflammation properties of a matrix-type silicone elastomer device providing sustained release of DL-lactide (a cyclic ester dimer of lactic acid). Lactide-loaded matrices were prepared by injection molding, and the devices were assessed for of in vitro release, anti-bacterial activity, and anti-inflammatory activity. The devices provided sustained release of lactide/lactic acid over five days and were effective against E. coli and S. aureus. Further, the devices reduced inflammation through activation of the GPR81 receptor via the NF-κB and JAK-STAT signalling pathway. These lactide-releasing silicone elastomer devices could improve clinical outcomes with certain short-term medical devices.
The Impact of Formulation on Dissolution Coning: Supporting Development of a Classification System and Predictive Tool
Authors: Arnold-Lockwood Evanthe , Sproston Kieran Ellis , Kraus Debbie , Brady Aaron Sean
Published: July 2023

Coning is a phenomenon that is specific to dissolution tests using USP Apparatus 2 due to the hydrodynamics of the system, resulting in the reduced dissolution of API. Experiments were conducted using design of experiment principles on various tabletted blends to investigate factors impacting coning. It was observed that the brittle filler used impacts the extent of coning present for the APIs studied. Particle size was found to have less of an impact than the brittle filler type. To resolve coning problems, it could be recommended that the brittle filler type is changed rather than the grade. Work with low solubility APIs is required to confirm this. This work has the potential to form the basis for a classification system to provide early warning if a formulation is likely to have coning issues.
Developing a Robust In Vitro Release Method for a Polymeric Nanoparticle: Challenges and Learnings
Authors: Paraskevopoulou Vasiliki , Mead Heather , Gibson Rhiannon , Amerio-Cox Marius , Taylor-Vine Georgia , Mann James
Published: July 2023

Nanomedicines have been highlighted as a promising approach for targeted drug delivery, as they can improve drug efficacy and reduce systemic toxicity. Due to the wide range of formulation types and the complex nature of the drug release mechanism, the development of an in vitro release (IVR) method for nanomedicines is challenging and regulatory guidance is limited. In this work, we are outlining the IVR method development for a controlled-release polymeric nanoparticle. This included the optimisation of the release medium composition and the selection of an appropriate sampling technique for the isolation of the released drug from the formulation. In addition to the established ultracentrifugation, the NanoDis showed potential as an automated technique.
Enhancing mucoadhesive properties of chitosan with methacryloyl and crotonoyl groups
Authors: Vanukuru Shiva , Khutoryanskiy Vitaliy , Al-Obaidi Hisham
Published: July 2023

Nasaldrug delivery holds promise for targeted administration to the brain. Mucoadhesivepolymers are crucial for prolonging drug retention in the nasal mucosa. Thisstudy focuses on synthesizing and characterizing novel derivatives by reactingchitosan with crotonic and methacrylic anhydrides. The structure of theresulting derivatives was confirmed through 1H NMR and FTIRspectroscopies, while turbidity measurements revealed pH-dependent solubilityprofiles. Spray-drying chitosan solutions with sodium fluorescein enabledflow-through studies and texture analysis, demonstrating improved retention on sheepnasal mucosa. The findings emphasize the potential of tailored chitosanmodifications for enhancing nasal drug delivery.  
Robotic microfluidic imaging of blood stimulation- towards high-throughput portable measurement of haemostasis
Authors: Sarıyer Rüya Meltem , Gill Kirandeep , Needs Sarah Helen , Hodge Daniel , Reis Nuno M. , Jones Chris Ian , Edwards Alexander Daniel
Published: July 2023

Measuringblood and platelet function is vital for the development and use of drugs thatcombat cardiovascular disease, such as anti-platelet drugs and other medicinesthat reduce the risk of thrombosis. We propose combining mass-produced microfluidicdevices with open-source robotic instrumentation to enable development of affordableand portable, yet high-throughput and high-performance haematological testing.A time- and distance-resolved fluid flow analysis by Raspberry Pi imagingintegrated with controlled sample addition and illumination, enablessimultaneous tracking of capillary rise in 120 individual capillaries within 5minutes. We showed that time-resolved microcapillary rise imaging permits bloodfunction measurement by measuring thrombin-triggered activation of globalhaemostasis. Thrombin stimulation slowed vertical fluid velocity, consistentwith a dynamic increase in viscosity. Microfluidic systems expandhaematological testing towards high-efficiency, multi-parameter blood analysisnecessary for understanding and improving cardiovascular health.
Investigation of lipid digestion by fungal and porcine lipase supplements for severe pancreatic insufficiency using the in vitro dynamic TIM model
Authors: Martins Garcia Tânia , Vrasidas Ioannis , Iphoefer Alexander , Lipowicz Bartosz.lipowicz
Published: July 2023

Exocrine pancreaticinsufficiency (EPI) is caused by insufficient secretion or limited activity ofpancreatic enzymes, especially lipase. Chronic pancreatitis (CP) is the mostcommon EPI disease. CP patients suffer from gastrointestinal symptoms such asdiarrhea, abdominal pain, and decreased uptake of nutrients as a consequence ofinadequate food digestion. To improve their nutritional status, pancreaticenzyme supplements can be orally administered, known as pancreatic enzymereplacement therapy (PERT). PERT is commonly based on oral porcinepreparations, despite their pH sensitivity which results in a limited timeframefor optimal activity. Instead, fungal enzymes could be used to prolong enzymeactivity duration, since they are active over a wide pH range. The performanceof fungal enzymes was compared to porcine enzymes by measuring total fattyacids under severe pancreatic insufficiency conditions in the tiny-TIMsgdynamic in vitro gastrointestinal model. Administration of 14.000 fungallipase units (Nortase) led to similar lipid digestion compared to 20.000porcine lipase units (Kreon and Pangrol). Additionally, opening the Nortasecapsules had no negative effect on fungal lipase activity. This workdemonstrates that fungal lipases, administered as capsules or powder, can beused as an alternative treatment for EPI patients.
Phase stability and polymorphism of a new naproxen salt
Authors: O'Meara Paul , Nénert Gwilherm , Dadivanyan Natalia
Published: July 2023

We report on thesynthesis and structural characterization of a new naproxen salt. In-situheating X-ray diffraction experiment allows us to determine the phase stabilityof the various polymorphic phases. Slow heating rate and repetitive scansstrategy were essential to probe all phases in presence. Contrary to previouslyreported absence of polymorphic forms for naproxen salt, this new salt exhibitsone metastable dihydrate form and five anhydrous phases. The crystal structuresof all phases were determined using the in-situ X-ray powder diffractiondata. 
Dissolution improvement of binary solid dispersions of Carbamazepine using Poly (2-ethyl-2-oxazoline) as the hydrophilic carrier.
Authors: Adeola Adebisi O
Published: July 2023

Theaim of this study was to design and evaluate the properties of soliddispersions of carbamazepine (CBZ) using poly (2-ethyl-2-oxazoline) (POX) asthe hydrophilic carrier. These binary solid dispersions were prepared at varyingdrug loadings using the solvent evaporation method. The samples were evaluatedfor their in vitro dissolution, and solid-state properties. There was over 350%increase in dissolution rate of CBZ in samples containing at least 50% POX.This study concludes that POX is an effective hydrophilic carrier for poorlysoluble drugs in solid dispersions. 
Proceso de Selección y Reclutamiento de Personal de Servicio en la Empresa KEIDS.A.
Authors: Chaluisa Navas Evelyn Dayana , Ruilova Narváez Erika Cristina , Campaña Tóala Dennise Azucena , Cando Ipiales Katia Pamela , Pilatasig Remache Darwin Israel , Galarza Barrera Kevin Esteban
Published: July 2023

El proceso de Reclutamiento y Selección de Personal de Servicio en una Empresa es un proceso estratégico y metódico en el cual la empresa identifica la necesidad de cubrir un puesto de trabajo que contribuirá al cumplimiento de sus objetivos. En primer lugar, se genera el requerimiento del puesto y se elabora un perfil detallado que incluye responsabilidades, habilidades, conocimientos y experiencia requerida. Luego, se establecen las condiciones laborales, como horario, puesto de trabajo y beneficios salariales. Asimismo, se evalúan los recursos necesarios para el puesto, como equipamiento y herramientas de trabajo, y se crea un plan de capacitación para fortalecer las habilidades y destrezas del trabajador. Es importante revisar y actualizar el perfil periódicamente para asegurar su relevancia y adaptabilidad a los cambios en la empresa. El siguiente paso es recibir a los candidatos, realizar entrevistas y evaluaciones de habilidades y desempeño, y seleccionar al candidato adecuado. El candidato seleccionado será contratado y se le proporcionará la capacitación necesaria para desempeñar el puesto.
Diseño de un sistema solar aislado para bombear agua de uso agrícola en Esmeraldas, Ecuador
Authors: Mendez Duran Jesús Heriberto
Published: July 2023

En las regiones rurales dispersas, los generadores solares fotovoltaicos son una solución fiable para el desarrollo rural, estas fuentes energéticas limpias, no contaminantes de bajo impacto ambiental y, a la vez renovables, aún no están disponibles en vastas regiones aisladas, donde las necesidades energéticas son pequeñas y hay una baja densidad poblacional donde los usuarios potenciales están diseminados. En este caso se presenta a la mayoría de las localidades dentro de la provincia de Esmeralda donde tienen un gran potencial de tierras agrícolas de siembra entre los cuales tienen ciclos vegetativos diferentes. Además, gozan de épocas con mayor radiación solar, que puede alimentar sistemas fotovoltaicos para bombeo de agua y así poder realizar este proyecto. La metodología aplicada es cualitativa. La metodología aplicada es cualitativa y se aplica una investigación documental recopilando datos relevantes de fuentes de alto impacto académicos sistemas de captación de agua, por lo que la energía fotovoltaica representaría una alternativa rentable, ya que es renovable, inagotable y limpia además de que actualmente los costos de los módulos fotovoltaicos están disminuyendo, posibilitando su uso y aplicación.
Autorregulación en el aprendizaje interdisciplinario en Emprendimiento y Gestión en estudiantes de Bachillerato
Authors: Medina-Gorozabel Glenda , Giler-Medina Patricio
Published: July 2023

El objetivo de investigación fue examinar la incidencia de la autorregulación en el aprendizaje interdisciplinario en Emprendimiento y Gestión en estudiantes de Bachillerato, de la Unidad Educativa “Carlos María Castro”, del Cantón Chone en Ecuador. Se empleó la investigación de campo con enfoque cuantitativo de investigación, y se aplicó un diagnóstico y una encuesta, como técnicas cuantitativas de investigación. A nivel teórico, se utilizó los métodos inductivos, analítico y el bibliográfico. Los resultados mostraron que pocos estudiantes dominan los aprendizajes requeridos, y que se presentan inconvenientes en el desarrollo de habilidades sociales y en el desenvolvimiento frente a los momentos de reflexión, meditación, tensión y preocupación en la autorregulación del aprendizaje interdisciplinario. Finalmente, se concluyó que una planificación didáctica de tipo interdisciplinar promueve mejores procesos de autorreflexión, monitoreo y retención cognitiva en los estudiantes cuando se establece una ruta metodológica que contempla la autorregulación pedagógica a través de acuerdos y compromisos.
La realidad aumentada como apoyo pedagógico en la educación
Authors: Añapa Quiñónez Pedro Luis , Rua Sanchez Luis Efren
Published: July 2023

La realidad aumentada es una tecnología que ha venido a transformar la manera en que se enseña y se aprende en la educación. Se trata de una tecnología que permite combinar elementos digitales (por ejemplo, imágenes, sonidos, videos) con el mundo real a través de dispositivos móviles y otros medios tecnológicos. El objetivo de artículo fue analizar los conceptos básico y claves de la realidad aumentada, el uso de la RA en la educación en mejora de la enseñanza-aprendizaje y los beneficios que esta tecnología tiene hacia el estudiante. En la metodología se realizó una búsqueda que resultó de 25 000 referencias de artículos científicos desde 2015 hasta 2023; de este listado se seleccionó 3 artículos internacionales; Leiva Olivencia y Moreno Martínez (2015) demuestra la motivación y cambios en el aprendizaje mediante proyectos en los diferentes niveles escolares; J. M. Barroso Osuna & Gallego Pérez (2017) se analiza una propuesta de formación al docente con enfoque en diseño, producción y evaluación con realidad aumentada
Metamorfosis y características de la educación venezolana en la época de Panademia
Authors: Marcano de Blanco Eladia del Jesús
Published: July 2023

El presente ensayo tiene como propósito dar a conocer los cambios y repercusiones de la Pandemia en el sector educativo en Venezuela, son diversas las opiniones emitidas con respecto al coronavirus Covid 19, virus el cual nació en Wuhan (China) el 31 de diciembre de 2019, no obstante, el sector educativo fue uno de los más afectado, sin olvidar la salud, de allí que este trajo consecuencias las siguientes, estudiantes que no pudieron culminar su carrera, atrasos en los programas, estudiantes y docentes con secuela del virus, escuelas desbalijadas por estar mucho tiempo desocupadas, muertes, para ello se aplicaron medidas como el apoyo a los estudiantes en Venezuela, este se brinda como parte del programa la Educación No Puede Esperar, lanzado por UNICEF y sus aliados para brindar acceso a la educación, el Ministerio de Educación aplicó un programa en Educación Básica denominado el programa cada Familia una Escuela y en la universidad, el Plan Universidad en Casa, se puede concluir, que la Pandemia tomó por sorpresa todos los ciudadanos a nivel mundial, sin embargo, también nos dejó un aprendizaje, se puede decir, que en Venezuela el talento de los docentes y demás profesionales se ha crecido con la crisis.
Moderating Effect of Green Image: The Influence of Beta on Stock Return
Authors: Sailendra Sailendra
Published: July 2023

This study aims to analyze the influence of green image on beta and stock return by considering the moderating effect of green image. The research sample consists of 44 proper companies listed in the Indonesia Stock Exchange (IDX) from 2018 to 2022, with a total of 220 year-observations. The study was analyzed using SEM-PLS statistics. The results indicated that green image does not have a significant impact on stock returns but shows a positive directional relationship. Similarly, beta also has no significant effect on stock returns but shows a positive relationship. As a moderating variable, green image moderates the effect of beta on stock returns in a negative direction. This study concludes that companies with a weak green image tend to experience a decrease in stock returns, and vice versa. In this case, green image acts as a moderating factor that affects the strength of the relationship between beta and stock returns. The findings of this study have important implications for practitioners and decision makers in evaluating and improving corporate image related to environmental issues. In addition, this study contributes to the academic literature in the accounting, finance and sustainability by providing a better understanding of the relationship between green image, beta, stock returns, and relevant moderating factors.
Governance of Street Lighting Provision in System Context, Driver, and Collaboration Dynamics Dimensions
Authors: Kurniadi  , Alwi
Published: July 2023

Energy efficiency is currently a very popular topic because the world's need for energy continues to increase every year. Street lighting is one sector that has great potential to be targeted for energy efficiency. The use of energy-saving street lighting technology is not easy to realize, due to limited technical knowledge, namely, the components of street lighting do not meet the Indonesian National Standard. Meanwhile, non-technical problems are limited budgets in providing street lighting. If the procurement of street lighting is associated with government budget constraints, then it is not wrong for the provision to be handed over to businesses or private entities. In this study, researchers analyzed the process of collaborative governance and the Public-Private Partnership scheme in providing street lighting in the city of Bandung. This study uses a qualitative approach. Determination of the sample by using critical sampling. Data collection techniques by performing observation, interview, documentation tracing, and audiovisual while the operational design in this study uses an integrative framework for a collaborative governance approach, namely system contexts, drivers, and collaboratives dynamics.
PENGARUH KESADARAN LINGKUNGAN DAN IKLAN HIJAU TERHADAP KEPUTUSAN PEMBELIAN PRODUK HIJAU
Authors: Hasanah Ana , Hindrayani Aniek , Noviani Leny
Published: July 2023

Kondisi bumi yang semakin mengkhawatirkan menuntut manusia untuk sadar terhadap kerusakan lingkungan yang salah satu upayanya adalah dengan membeli produk hijau. Penelitian ini akan menguji pengaruh kesadaran lingkungan dan iklan hijau terhadap keputusan pembelian air mineral kemasan berekolabel. Populasi penelitian berjumlah 679 yang merupakan mahasiswa Pendidikan Ekonomi dari universitas negeri di Jawa Tengah. Diperoleh sampel berdasarkan rumus Slovin 252 mahasiswa. Penelitian menggunakan teori keputusan pembelian konsumen. Uji validitas dan reliabilitas digunakan untuk menguji intrumen penelitian berbantuan SPSS 25 yang dilanjutkan empat uji prasyarat analisis. Regresi linear berganda digunakan untuk menganalisis pengaruh lebih dari dua variabel indpenden. Diperoleh hasil bahwa kesadaran lingkungan (0,000) dan iklan hijau (0,000) berpengaruh positif dan signifikan terhadap keputusan pembelian air mineral kemasan berekolabel denga besarnya pengaruh adalah 48%. Hasil penelitian menunjukkan pentingnya kesadaran lingkungan dan iklan hijau untuk mendorong mahasiswa membuat keputusan membeli produk hijau.
PEMANFAATAN E-COMMERCE DALAM PENGEMBANGAN UMKM KERAJINAN TENUN GEDOGAN PERSPEKTIF EKONOMI ISLAM DI KECAMATAN PRINGGASELA
Authors: Vianti Rinda Astri , Ro’is Ihsan , Singandaru Adhitya Bagus
Published: July 2023

Penelitian ini bertujuan untuk mengetahui Pemanfaatan e-commerce dalam Pengembangan Usaha Mikro Kecil dan Menengah (UMKM) Kerajinan Tenun Gedogan di Kecamatan Pringgasela dalam Perspektif Ekonomi Islam. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Teknik pengumpulan data yang digunakan adalah teknik wawancara secara mendalam, dokumentasi, dan observasi. Pengumpulan data dan penentuan informan penelitian menggunakan teknik purposive dan snowball. Sumber data penelitian yaitu menggunakan data primer dan data sekunder. Pemeriksaan atau validasi data menggunakan teknik triangulasi yaitu triangulasi sumber dan triangulasi metode.

Hasil penelitian ini menunjukan bahwa pemanfaatan e-commerce dalam  pengembangan UMKM di Kecamatan Pringgasela cukup maksimal, hal tersebut dibuktikan dengan adanya upaya pemanfaatan media digital berupa e-commerce dalam pengembangan usaha. Penelitian ini juga menunjukan bahwa pemanfaatan e-commerce dalam pengembangan UMKM tenun Gedogan dalam perspektif ekonomi islam sudah mampu dicerminkan oleh pelaku UMKM tenun Gedogan di Kecamatan Pringgasela.
ANALISIS PERGESERAN EKONOMI SEKTOR UNGGULAN DENGAN SHIFT-SHARE PADA PEREKONOMIAN PROVINSI NUSA TENGGARA BARAT TAHUN 2019-2022
Authors: Fadlli Muhammad Dzul , Hidayat Ali Akbar , Husni Vici Handalusia , Anggara Jaka , Hutabarat Ruth Eviana
Published: July 2023

Kondisi pandemik membawa banyak perubahan dalam aktivitas ekonomi termasuk diantaranya terbuka peluang adanya pergeseran sektor ekonomi unggulan. Pada penelitian ini ingin menganalisis pergeseran ekonomi sektor unggulan dengan shift-share pada perekonomian provinsi Nusa Tenggara Barat Tahun 2019-2022. Penelitian ini menggunakan pendekatan kuantitatif deskriptif. Adapun teknik analisis data akan menggunakan shift-share. Adapun data yang digunakan yaitu data sekunder berupa data produk domestik regional bruto NTB dan produk domestik bruto Indonesia yang diambil dari BPS. Mayoritas sektor ekonomi di NTB tergolong memiliki pertumbuhan yang lamban. Terdapat 10 sektor yang dianggap lamban pertumbuhannya. Hanya terdapat 7 sektor yang dianggap progresif/maju.
Pengaruh Pertumbuhan Ekonomi dan Kesempatan Kerja terhadap Indeks Pembangunan Manusia di Kota Palangka Raya 2017-2022
Authors: Suherman  , Nurhidayat Ahmad Fauzi , Sutrisno Feby Adila Indria , Sutrisno Depy Rizkika Indria , Astuti Devi , Maha Egi Ispreidi
Published: July 2023

Sejauh ini pelaksanaan pembangunan yang dilakukan oleh pemerintah di Indonesia seringkali kurang bahkan tidak  sesuai dengan kebutuhan masyarakat pada umumnya. Pola pembangunan yang  dilaksanakan pemerintah kurang memeperhatikan kebutuhan masyarakat sehingga bisa menimbulkan kesejahteraan masyarakat didaerah terjadi penurunan, hal tersebut dilihat dari besar ataupun kecilnya IPM dimana hal ini menjadi langkah pemerintah untuk melaksanakan pembangunan masyarakat yang tujuannya agar memiliki lebih banyak opsi, khususnya dalam menjalankan aktivitas ekonomi.

Penelitian ini menerapkan pendekatan kuantitatif yaitu mengumpulkan data sekunder berupa informasi time series dari tahun 2017 - 2022. Regresi linier berganda digunakan dengan perangkat lunak analisis data. Penelitiian ini bertujuan menentukan kontribusi variabel pertumbuhan ekonomi dan kesempatan kerja dalam menentukan variabel yang berpengaruh dalam menentukan indeks pembangunan manusia.

Besaran pengaruh variabel secara Bersama-sama (simultan) dari kedua variabel independen yang memiliki koefisien determinasi sebesar 0,79 (R-Square). Selain itu, hasil dari beberapa analisis menggambarkan variabel X1 (pertumbuhan ekonomi) mempunyai dampak paling negatif terhadap pembangunan manusia. Disimpulkan kesempatan kerja (variabel X2) memiliki pengaruh positif dan signifikan secara statistik terhadap IPM jika nilai koefisiennya 0,729 dan probabilitasnya < 0,05 yaitu 0,047.
ANALYSIS OF THE IMPACT OF COVID-19 ON INCREASING LABOR INCOME IN EAST JAWA
Authors: Arisetyawan Kukuh , Pudjihardjo M. , Attaqi Lifya Fillahi , Putri Natasya Aditya , Maharatni Rina Dwi
Published: July 2023

The Covid-19 pandemic has forced the Government to set a large-scale social restriction policy. This policy impacts all areas of life, including economic growth and employment in East Java, especially income sustainability. This study aimed to identify the influence of sociodemography on the increase in worker income during the Covid-19 period in East Java. The data from this study is secondary data from the results of SAKERNAS 2020 obtained from BPS. The data were analyzed using the Multiple Regression Analysis methods. The results of this study indicate that the dependent variable, Covid, Gender, Age, Working Hours, Work From Home, Internet, Promotion, Formal Sector, and transactions significantly affect workers' income during the pandemic. In contrast, the dependent variable communication does not substantially affect workers' pay during the pandemic.
ANALISIS PERSEPSI MASYARAKAT TERHADAP RENCANA PEMBANGUNAN PEMBANGKIT LISTRIK TENAGA BAYU (PLTB) DI KECAMATAN JEROWARU
Authors: Wafik Ahmad Zaenal
Published: July 2023

Tujuan dari Penelitian ini antara lain, 1) Mengetahui dan mendeskripsikan rencana pembangunan Pembangkit Listrik Tenaga Bayu (PLTB); 2) Mendeskripsikan persepsi masyarakat terhadap rencana pembangunan PLTB; 3) Mengidentifikasi faktor-faktor yang mempengaruhi persepsi masyarakat. Penelitian ini menggunakan metode survei. Teknik Pengambilan sampel sebanyak 60 responden yang diambil secara aksidental sampling. Teknik analisis yang digunakan adalah analisa deksriktif kuantitatif, dan analisis Kendall tau-b. Hasil penelitian menunjukkan bahwa Pemerintah Daerah Provinsi Nusa Tenggara Barat memberikan dukungan yang optimal terkait rencana pembangunan PLTB. Lebih lanjut hasil penelitian menunjukkan bahwa secara umum masyarakat masih belum mengetahui dampak turunan akibat dibangunanya PLTB dan masyarakat masih beranggapan bahwa pembangunan PLTB belum memberikan dampak ekonomi bagi masyarakat setempat. Adapun hasil analisis kuantitatif menunjukkan bahwa terdapat empat faktor yang memiliki hubungan mempengaruhi persepsi masyarakat setempat yaitu umur, pengetahuan, pendidikan, dan pekerjaan.
ANALISIS PENGARUH MAKRO EKONOMI TERHADAP INDEKS HARGA SAHAM SYARIAH INDONESIA
Authors: Hidayat Ali Akbar , Hak Muhamad Bai'ul , Arkandia Lalu Dema
Published: July 2023

Penelitian ini bertujuan untuk menganalisis pengaruh variabel makro ekonomi terhadap indek harga saham syariah Indonesia. Variabel makro dalam penelitian ini adalah inflasi dan nilai tukar rupiah. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan asosiatif. sampel dalam penelitian ini diambil dari januari tahun 2018 sampai dengan desember 2022. Analisis data menggunakan uji asumsi klasik dan regresi linier berganda dengan uji secara parsial. Hasil penelitian ini menunjukkan bahwa inflasi berpengaruh positif dan signifikan terhadap indeks harga saham syariah, sementara nilai tukar rupiah berpengaruh negative dan signifikan terhadap indeks harga saham syariah di Indonesia. Sedangkan nilai koefisien determinasinya sebesar 47,9 persen.
W artykule jego autorzy wskazują na przesłanki i powody tak zwanych kolorowych rewolucji, sięgając do przykładu rewolucji pomarańczowej na Ukrainie i dżinsowej rewolucji na Białorusi. Podejmują próbę wskazania podobieństw i różnic społeczno-gospodarczym i politycznym. Poddają analizie taktykę i strategię grup protestujących i sił opozycyjnych, w obydwu krajach. Zwracają także szczególną uwagę na kryteria, sprzyjające zwycięskiemu zakończeniu pomarańczowej i upadku dżinsowej rewolucji.
Authors:   Ivan Franko National University of Lviv, Skochylyas Lyubomyr , Hajduk Jurij
Published: July 2023

W artykule jego autorzy wskazują na przesłanki i powody tak zwanych kolorowych rewolucji, sięgając do przykładu rewolucji pomarańczowej na Ukrainie i dżinsowej rewolucji na Białorusi. Podejmują próbę wskazania podobieństw i różnic społeczno-gospodarczym i politycznym. Poddają analizie taktykę i strategię grup protestujących i sił opozycyjnych, w obydwu krajach. Zwracają także szczególną uwagę na kryteria, sprzyjające zwycięskiemu zakończeniu pomarańczowej i upadku dżinsowej rewolucji.
Transformation of the Republic of Bulgaria and politicization of the society’s ethnic awareness
Authors:   Yuriy Fedkovych Chernivtsi National University, Burdiak Vira
Published: July 2023

ABSTRACT: The paper deals with politicization of ethnic awareness of the society over the period of trans- formational changes, what especially negatively revealed in the Balkans. Permanent, relentless conflicts, which loomed large in the region in the 90s of the previous century, occasionally emerge nowadays. However, the state despite all events which take place in the neighboring countries and complexity of internal political, social and economic situation managed to avert apparent social confrontation. The analysis of the transformational process in Bulgaria gives us reasons to conclude that the state lacks a clear program of ethnic policy development, while manifestations of nationalism were enough to commence the changes. After joining the EU and NATO situation in the country experienced a vast improvement.
The identity of Ukrainians and Russians at the background of ethnic relations in the independent Ukraine (1991–2017)
Authors:   Akademia Nauk Stosowanych Gospodarki Krajowej, Białobłocki Tomasz
Published: July 2023

The article is dedicated to analyzing the problem of formation and characteristics of Ukrainian and Russian identity at the background of ethnic relations in the independent Ukraine. The author revealed an array of problems that determine the confrontation of Russian and titular ethnic groups in Ukraine. The researcher argued that it is impossible to isolate the mechanisms of authentication and identity of Ukrainians and Russians in Ukraine, but instead it is useful to examine all the trends, which characterize ethnic relations in Ukraine, in depth.
Громадські структури як дієвій механізм формування соціального капіталу у демократичних країнах
Authors: Varinski Vladislav
Published: July 2023

In of the article the mechanisms of forming of social capital is examined in modern countries. It of is shown that accumulation and зрістання of social capital maybe only in democratic countries. Reasonably, that him the purposeful forming and increase in space of міжособових, intergroup connections and relations gives an opportunity to find a way to harmonization of political, social, economic interests, to improve possibilities them rational expression at state level. The of presence of social capital directly influences on the achievement of stability in society and assists to democratic development, and his absence, the disconnected brakes development of civil society.
Isolation and taxonomy of semi-presidentialism with nominal presidents in central and Eastern European Countries of the EU: as exemplified by Bulgaria, Czechia, Slovakia and Slovenia
Authors:   Ivan Franko National University of Lviv, Lytvyn Vitaliy
Published: July 2023

The article is dedicated to theoretical, methodological and empirical justification for different types and systems of republican government. The author conducted the comparative analysis of the presidential powers in various systems of republican government and explained the nature and different types of semi-presidential systems of government as exemplified by Central and Eastern European countries of the EU. The researcher also argued and identified the main attributes of semi-presidentialism with nominal presidents in the context of its distinction from parliamentarism as exemplified by Bulgaria, Czechia, Slovakia and Slovenia and defined the correlation between parliamentary democracy, semi-presidentialism and parliamentarism.
Social-political and social-economic transformation of the Slovak Republic
Authors: Butyrskaya Iryna
Published: July 2023

The way of the Slovak Republic (SK) towards democracy and market economy appeared to be very hard. Starting position for implementation of reforms objectively was less favorable in comparison with the neighboring countries. The fundamental law of the SK guaranteed political pluralism, civil rights and liberties for citizens. In 2004 the state became a full member of the EU and NATO. In 2005 main macroeconomic indices of the state reached a threshold level, established by the Maastricht Treaties, and as to the rate of GDP increase and direct foreign investment Slovakia joined the EU leaders. Along with the achievements in the political life of the country there are also serious continuous problems. Among them are: irredentist attitudes among the Hungarian minority which fuel conflict potential in the Slovak-Hungarian relationship; hardships of social integration of the Roma population. An acute problem is corruption, the level of which is higher than in other Visegrad countries. Aiming at formation of conditions for stable continuous growth Slovakia carries out a “reset” of the economic policy. Large-scale reforms of the social system and social policy in SK have been implemented.
Technocratic governance and democracy: key contradictions, their consequences and ways to overcome
Authors:   Akademia Nauk Stosowanych Gospodarki Krajowej, Białobłocka Magdalena
Published: July 2023

The article is devoted to the comparison of the concepts of technocracy/technocratic governance and democracy, as well as checking how democratic a nature of technocratic governance is. It was argued that technocratic governance is in opposition to democracy, but rather borders with autocracy (non-democracy) and found out that technocratic governance leads to weakening the procedures of delegation of authority and accountability between voters and parties, parties and governments, increasing external pressure on politicians and weakening ideological patterns of political process. The researcher confirmed that technocratic governments lack political competition, participation of citizens as key “principals” of democratic political regimes and political legitimacy. However, it was conceptualized that technocratic governance has both positive and negative moments through the prism of democracy: positive moments are short-term and negative moments are long-term. The author determined that the formation of technocratic governments in the long-term/repetitive perspective is not democratic, because it leads to patrimonialism of various inter-institutional relations. On the other hand, it was found that the more democratic is a political system, the greater is the likelihood that technocratic governments and technocratic governance will be temporary.
Political parties of the Czech Republic on the way to consolidated democracy
Authors: Fedorchak Tetiana
Published: July 2023

The paper deals with the development of the political process in the Czech Republic in the first post-communist decade. It is characterized by a special struggle between two biggest political parties, which surprisingly for the Czech society made a political deal – “Agreement on the Creation of a Stable Political Environment in the Czech Republic”, signed by the Czech Social-Democratic Party and the Civic Democratic Party. Other parties considered this agreement to be a “deception of voters” and during the course of the election campaign severely criticized both “pro-communist” social-democrats and “entirely corrupted” civic democrats. The above mentioned period was characterized by controversial, complicated and ambiguous development, but the outcomes are clear – transformation of the Czech Republic into a stable European country with a well-established market economy and sustainable political system.
Vitaliy Dubenskyi — The Hesychast-Poet
Authors:   Ivan Franko National University of Lviv, Harat Ivan , Kralyuka Petro
Published: July 2023

The paper partly examines the biography of the poet and monk Vitaliy Dubenskyi. The author includes an analysis of Dubenskyi’s work, called «Dioptra …», which is a classic example of hesychast literature. Great attention is paid to the criticism of the «earthly world» and its opposition to the «divine world». Elements of humanism in Dubenskyi’s poetic writings are also noted.
Patterns of minority governments’ stability in European parliamentary democracies
Authors:   Akademia Nauk Stosowanych Gospodarki Krajowej, Paczak-Białobłocka Nadija
Published: July 2023

The article is dedicated to analyzing patterns of minority governments’ stability in European parliamentary democracies, in particular in the European systems of positive and negative parliamentarism (in 1944-2016). The author found that minority governments are relatively less stable than majority governments. However, the researcher argued that the single-party minority governments on average are more stable than minority coalition governments.