bluuebunny/crossref_metadata_2025 huggingface dataset:
Radiomics in the Diagnosis of Gastric Cancer: Current Status and Future
Perspectives
Authors: Wang Zhiqiang , Li Weiran , Jin Di , Fan Bing
Published: October 2023

Gastric cancer is a malignant cancerous lesion with high morbidity and mortality. Preoperative diagnosis of gastric cancer is challenging owing to
the presentation of atypical symptoms and the diversity of occurrence of focal gastric lesions. Therefore, an endoscopic biopsy is used to diagnose
gastric cancer in combination with imaging examination for a comprehensive evaluation of the local tumor range (T), lymph node status (N), and
distant metastasis (M). The resolution of imaging examinations has significantly improved with the technological advancement in this sector.
However, imaging examinations can barely provide valuable information. In clinical practice, an examination method that can provide information
on the biological behavior of the tumor is critical to strategizing the treatment plan. Artificial intelligence (AI) allows for such an inspection
procedure by reflecting the histological features of lesions using quantitative information extracted from images. Currently, AI is widely employed
across various medical fields, especially in the processing of medical images. The basic application process of radiomics has been described in this
study, and its role in clinical studies of gastric cancer has been discussed.
Global Publication Trends and Research Hotspots of the Immune System
and Osteoporosis: A Bibliometric and Visualization Analysis from 2012 to
2022
Authors: Zhao Jinlong , Dou Yaoxing , Liang Guihong , Huang Hetao , Hong Kunhao , Yang Weiyi , Zhou Guanghui , Sha Bangxin , Liu Jun , Zeng Lingfeng
Published: October 2023

Background::

Osteoporosis (OP) is a systemic bone metabolism disorder in which the
immune system and bone metabolism interact.

Objective::

The purpose of this study was to explore the research status, hot spots and trends regarding
the influence of the immune system on OP and to provide a basis for research directions
and applications in this field.

Methods::

We searched and collected literature about the immune system and OP published
from 2012 to 2022 in the Web of Science Core Collection database. All the included studies
were subjected to bibliometrics analysis using Hiplot Pro, VOSviewer and CiteSpace software
to produce statistics and visual analyses of the literature output, countries, institutions, authors,
keywords and journals.

Results::

A total of 1201 papers were included, and the number of citations of these articles
reached 31,776. The number of publications and citations on the immune system and OP has
increased year by year. The top three countries with the greatest number of papers published
were China, the United States of America (USA) and Italy. The two institutions with the largest
number of papers published were Sichuan University and Soochow University, both located in
China. De Martinis Massimo (Italy) and Ginaldi Lia (Italy) are prolific authors in this field. The
representative academic journals are Osteoporosis International, Frontiers in Immunology,
Journal of Bone and Mineral Research, PloS One and Bone. The results of the keyword cooccurrence
analysis showed that the research topics in this field mainly focused on T cells, cytokines,
signaling pathways, vitamin D, postmenopausal OP and immune diseases. The keyword
burst results showed that zoledronic acid, chain fatty acids and gut microbiota are the frontiers
and trends of future research on this topic.

Conclusion::

The influence of the immune system on OP has been widely studied, and the current
research in this field focuses on the effect or mechanism of immune-related cytokines, signaling
pathways and vitamin D on OP. Future research trends in this field should focus on the
immune regulation mechanism and clinical transformation of zoledronic acid, chain fatty acids
and the gut microbiota in OP.
Eco-friendly Synthesis of Indole Conjugated Chromeno[d]Pyrimidines as
Anti-cancer Agents and their Molecular Modelling Studies
Authors: Raju Datla Venkata Rama Krishnam , Jha Anjali
Published: October 2023

Introduction:

Many medicinally active new chemical entities depend on indole conjugated
chromeno[d]pyrimidine derivatives as a building block. The synthesis of 4-(1H-indol-3-yl)-3,4-
dihydro-1H-chromeno[4,3-d]pyrimidine-2,5-dione 4 were achieved in the current study by treating 4-
hydroxy-2H-chromen-2-one 1, indole aldehydes 2, and urea/thiourea 3 in the presence of L-proline.

Methods:

By adopting the above protocol, we were able to synthesize eight compounds, i.e. 4-(1Hindol-
3-yl)-3,4-dihydro-1H-chromeno[4,3-d]pyrimidine-2,5-diones (4a-4h), in the presence of Lproline
as a catalyst in ethanol as solvent for 2-3 hours at 70-75°C with decent yields of 80-85%, and
their structures were ascertained by various spectral techniques. They were further screened for their
potentiality to inhibit cancer growth in HepG2 and MDA-MD-231 cells.

Results:

The scope of the synthesis of biological relevant Indole conjugated Chromeno[
d]Pyrimidines by three-component reaction (MCRs) process was investigated. The most optimised
conditions obtained were 0.3 eq of L-proline for 2 hours at 70-75°C which gave the best yield
(85%). The few advantages of this newly developed method are excellent yields, no metal catalyst,
less toxic solvents, simple workup no chromatographic column purifications. On further screening
for their anticancer activities, out of all, the compound 4b displayed noteworthy cytotoxicity with
IC50 values of 8.1 and 9.2 μM against HepG2 and MDA-MD-231, respectively. Additionally, in silico
studies also supported that compound 4b had favourable binding energy (-7.8 kcal/mol) when compared
to the co-crystal ligand (LS5) in inhibiting the human cyclin-dependent kinase 2 (CDK2) protein.

Conclusion:

In conclusion, we have developed a simple, convenient, and efficient method for the
synthesis of structurally diverse indole conjugated chromeno[d]pyrimidine analogues in the presence
of L-proline as catalyst in ethanol as solvent with good yields. Further, the in vitro cytotoxic studies
against HepG2 and MDA-MD-231 cells demonstrated that the synthesized compounds had good to
reasonable activity, except for compound 4d.
The Seeking Proxies for Internal States (SPIS) Model of OCD – A
Comprehensive Review of Current Findings and Implications for Future
Directions
Authors: Lazarov Amit , Liberman Nira , Dar Reuven
Published: October 2023

The Seeking Proxies for Internal States (SPIS) model of obsessive-compulsive disorder
(OCD) explains symptoms of OCD as stemming from attenuated access to internal states, which is
compensated for by using proxies, which are indices of these states that are more discernible or less
ambiguous. Internal states in the SPIS model are subjective states that are not accessible to others, encompassing
physiological states, motivations, preferences, memories, and emotions. Compensatory
proxies in OCD include fixed rules and rituals as well as seeking and relying on external information.
In the present review, we outline the SPIS model and describe its basic tenets. We then use the SPIS
conceptualization to explain two pivotal OCD-related phenomena - obsessive doubt and compulsive
rituals. Next, we provide a detailed overview of current empirical evidence supporting the SPIS in
several domains, including physiological states, emotions, sense of understanding, decision-making,
and sense of agency. We conclude by discussing possible neural correlates of the difficulty in accessing
internal states, focusing on the anterior insular cortex (AIC) and highlighting potential clinical implications
of the model to the treatment of OCD.
Low-density Lipoprotein Cholesterol Reduction Therapies for Secondary
Prevention in Patients with Stroke: A Network Meta-analysis
Authors: Wang Xing , Zheng Jun , Chen Yuqi , You Chao , Ma Lu
Published: October 2023

Background:

Patients with previous strokes are at a higher risk of stroke recurrence. Current
guidelines recommend a range of low-density lipoprotein cholesterol (LDL-C)-lowering treatments
to reduce the risk of recurrent stroke. However, the optimal agent for decreasing LDL-C to lower
the risk of recurrent stroke remains unclear. This study aimed to assess the relative effects of various
LDL-C -lowering agents for secondary stroke prevention.

Methods:

Several databases were searched from inception up to 2022. Only randomized controlled trials
that compared different LDL-C-lowering agents in adult patients with previous strokes were included.
The primary endpoint was a recurrent stroke. The surface under the cumulative ranking curve
(SUCRA) was also applied to estimate the overall ranking probability of the treatment agents for each
outcome.

Results:

Overall, nine trials comprising 17,226 patients were included. Ezetimibe plus statins (RR:
0.56, 95% CrI: 0.35-0.87) and statins alone (RR: 0.90, 95% CrI: 0.81-1.00) reduced the risk of stroke
recurrence. Ezetimibe plus statins was superior to statins alone in decreasing the incidence of recurrent
stroke (RR: 0.62, 95% CrI: 0.39-0.95). However, treatment with statins was related to an increased
risk of hemorrhagic stroke compared to placebo (RR: 1.57, 95% CrI: 1.13-2.21). All agents were related
to a decreased incidence of major adverse cardiovascular events.

Conclusion:

Treatment with ezetimibe plus statins was suggested as the most efficacious in decreasing
the incidence of recurrent stroke. The analysis also revealed that statin monotherapy was related to
an increased risk of hemorrhagic stroke.
Contemporary Trends in Drug Repurposing: Identifying New Targets for Existing Drugs
Authors: Bhagat Srikant , Kumar ,Asim , Joshi Gaurav
Published: October 2023

Drug repurposing or drug repositioning has emerged as an efficient, very
popular and alternative technique in modern drug discovery to identify old drugs for
new targets cost-effectively and dynamically. This concept gets a tremendous boost,
especially in the century's most challenging healthcare concern of the Covid-19
pandemic across the globe. In this approach, scientists seek new indications and
clinical use of the drugs at minimum risk, which have previously already been
pharmacologically established and approved. The methods developed for drug
repositioning include computational approaches and biological methodologies, and
with the fast technological advancement, various new drug-target- diseases are
discovered, and thereby immense information is now available in the different
databases, such as DrugBank, OMIM, ChemBank, KEGG, Pubmed, Genecard, and
many more. The information available on all the above public domain databases has
been utilized successfully in many drug repositioning projects. The present chapter
discusses the concept of drug repurposing and its impact on academia, industries and,
of course, their social implications. Besides this, the chapter will also cover details on
tools and techniques to identify drugs for repositioning and their application in
identifying drugs for various diseases and disorders. The current work will also foresee
the recent market analysis and updates on the cost of drug discovery and development
by drug repurposing, its comparison with traditional drug discovery approaches,
challenges involved with drug repurposing, and future perspectives.
Fast Foods: Chemical Composition and Implications for Health
Authors: Kumari Ruchi , Singh Ravi S.
Published: October 2023

With changing the scenarios of living style, professional work culture, and
daily hectic routine, liberal and global thoughts are impacting our dietary patterns and
normal food consumption. So the preference for foods is changing, and foods that can
be ready in a shorter time, like “fast foods”, are gaining popularity among the masses,
especially young generations. The fast food business has become one of the fastest-growing industries across the globe. This growing trend of fast food consumption has
also brought several health-associated issues, like obesity and heart-related problems.
Therefore, health-conscious people do like to know the chemical ingredients embedded
in fast foods as well as their packaging and storage. For this purpose, the chemistry
relating to quality aspects of fast foods, including nutritional, physiological, sensory,
flavor, microbiological and packaging, is very important for healthy consumption of
fast food for a healthy life. In this book chapter, we have made efforts to bring updated
information related to fast food, its chemical composition and implications for human
health.
Aeroacoustic assessment of blended wing body configuration with low noise technologies
Authors: Adamo F.P.
Published: October 2023

Abstract. An aeroacoustic assessment of promising novel aircraft concepts (BOLT and REBEL, two Blended wing bodies respectively with conventional and hybrid engines) devoted to fly in 2035-2050 scenario coupled with Low Noise Technologies (LNT) developed inside the framework of ARTEM project (H2020)[1] has shown. The noise assessment of each noise source of the AAC (Advanced Air Concepts) has been provided including the attenuation due to the masking effects due to the fuselage. The results are then used for the noise impact on the ground, through a ray-tracing method and taking into account the installative effects, with a comparison with standard/similar aircraft. Finally, the noise assessment of a AAC&Standard fleet on a reference airport has been provided.
Refined structural theories for dynamic and fatigue analyses of structure subjected to random excitations
Authors: Filippi M.
Published: October 2023

Abstract. This paper presents the application of low- and high-fidelity finite beam elements to analyze the dynamic response of aerospace structures subjected to random excitations. The refined structural models are developed with the Carrera Unified Formulation (CUF), enabling arbitrary finite element solutions to be easily generated. The solution scheme uses power spectral densities and the modal reduction strategy to reduce the computational burden. The response of an aluminum box beam is studied and compared with a solution obtained by a commercial code. Considering the root-mean-square value of the axial stress, an estimation of the fatigue life of the structure is obtained.
Overview of spacecraft fragmentation testing
Authors: Lopresti S.
Published: October 2023

Abstract. Spacecraft fragmentation due to collisions with space debris is a major concern for space agencies and commercial entities, since the production of collisional fragments is one of the major sources of space debris. It is in fact believed that, in certain circumstances, the increase of fragmentation events could trigger collisional cascade that makes the future debris environmental not sustainable. Experimental studies have shown that the fragmentation process is highly complex and influenced by various factors, such as the material properties, the velocity and angle of the debris impact and the point of collision (e.g. central, glancing, on spacecraft appendages). In recent years, numerous impact tests have been performed, varying one or more of these parameters to better understand the physics behind these phenomena. In this context some tests have been also performed at the hypervelocity impact facility of the university of Padova. This paper provides an overview of the main experiments performed, the most critical issues observed and proposes some future directions for further research. Moreover, it summarizes the current state of research in spacecraft fragmentation, including the methods and techniques used to simulate debris impacts, the characterization of fragment properties and the analysis of the resulting debris cloud.
Electro-thermal dynamic simulations and results of a deorbiting tethered system
Authors: Anese G.
Published: October 2023

Abstract. Deorbiting techniques with small or better no propellant consumption are an important and critical field of space studies for the mitigation of orbital debris. Electrodynamic tethers (EDTs) are of particular interest because they make possible to deorbit space debris by exploiting the Lorentz force that is provided by the current flowing in the tether thanks to the interaction of the system with the Earth’s magnetosphere and the ionosphere. This paper focuses on the differences between two software packages built at the University of Padova (FLEX and FLEXSIM) and their results in simulating various deorbiting scenarios. Both FLEXSIM and FLEX simulate the electro-thermal behaviour and the dynamics of an EDT. However, while the first one has the simplifying assumption that the tether is always aligned with the local vertical, the second one considers also the overall system attitude with respect to the radial direction and the tether flexibility. The computational times of these S/W are very different and it is important to understand the scenarios that are more appropriate for their use. Results aim to show the impact of different solar activity (simulations are done at different epochs) and lengths of conductive and non conductive segments of tether, in the range of a few hundreds of meters, on the total re-entry time. As expected, deorbiting is faster for high solar activity and conductive tether length but the performance must be balanced against the dynamics stability. The issue of stability over the deorbiting time is evaluated numerically for specific cases by using FLEX.
Low-energy earth-moon mission analysis using low-thrust optimal and feedback control
Authors: Almonte A.
Published: October 2023

Abstract. This work is focused on designing a low-energy orbit transfer in the Earth-Moon system, aimed at reaching stable capture in a highly elliptical lunar orbit, with the use of low-thrust propulsion. The mission at hand includes three different phases: low-energy ballistic transfer starting from Earth, low-thrust minimum-fuel arc, and low-thrust lunar orbit insertion using variable-thrust nonlinear orbit control. First, a reference trajectory is generated in the framework of the Patched Planar Circular Restricted Three-Body Problem (PPCR3BP), leveraging invariant manifold dynamics. Trajectory propagation is performed using the Bicircular Restricted Four-Body Problem (BR4BP) model. Particle swarm optimization is applied for trajectory refinement and to detect the subsequent minimum-fuel low-thrust arc. Finally, the lunar orbit is entered thanks to the use of variable-thrust nonlinear orbit control.
The application of modal effective mass for PCB friction lock compliance against spacecraft launch random vibration spectrum
Authors: Wylie M.
Published: October 2023

Abstract. Modern spacecraft design requires high density, low mass, modular electronic system architectures. This format often utilises a common backplane with Printed Circuit Boards (PCBs) interconnects. Adaptable electronic systems, such as modular Data Acquisition (DAq) systems, allow for configuration via insertion and removal of modules to meet the mission requirements. Common methods to mechanically fix the PCB to the chassis are by using stand-offs, with the primary function to minimise displacement through structural rigidity and to provide strain relief to the electronic connectors. Other methods, such as PCB friction lock allow for strain relief, improved thermal grounding of the PCB to the chassis but also allows for easy insertion and removal of the PCBs. One disadvantage of this system is that the retention force of the PCB is carried by a friction lock device and under acceleration loads, typically experienced in the launch environment, may cause failure. This paper presents a method to establish compliance of PCB friction lock devices using modal Finite Element Analysis (FEA) to predict the resonant frequencies and their Mass Participation Factor (MPF). Using this data, it is proposed that the use of an adaptation of the Miles Equation along with an equivalent g-RMS estimation can be used to determine the Random Vibration Load Factors (RVLF). A comparison of the RVLF with the retention force of the friction lock device can then give insight to the friction joint compliance.
Labyrinth quarter-wavelength tubes array for the reduction of machinery noise
Authors: Catapane G.
Published: October 2023

Abstract. Anthropogenic noise from navigation is a major contributor to the disturbance of the acoustic soundscape in underwater environments. The noise generated by ship’s machinery exhibits energetic tonal harmonic peaks at multiples of the rotating and firing frequency, that occur in the 20-200 Hz frequency range and difficult to control with classical soundproofing materials. Quarter wavelength tubes (QWT) can be a concrete solution since their absorption peaks are harmonic odd integers of the first resonance frequency. The main issue of QWT is their tuning length, which equals 1.43 m for a 60 Hz resonator. The problem is solved by coiling the tube into a labyrinth. Three labyrinth quarter wavelength tubes are tuned respectively at 60, 90 and 120 Hz. Samples are printed with filament 3D additive manufacturing techniques using PLA and tested with a square impedance tube designed for low-frequency measurements. Measurement results are in good agreement with analytical and numerical predictions. An array including four 60 Hz, four 90 Hz and four 120 Hz labyrinths QWTs is finally tested.
Hardware-in-the-loop validation of a sense and avoid system leveraging data fusion between radar and optical sensors for a mini UAV
Authors: Fiorio M.
Published: October 2023

Abstract. The present work illustrates the results obtained at the conclusion of the three-year project TERSA (Tecnologie Elettriche e Radar per Sapr Autonomi), involving the aerospace section of the Dept. of Civil and Industrial Engineering (DICI) of the University of Pisa and its industrial partners. The project aimed at the design and development of a fully autonomous Sense and Avoid (SAA) prototype system, based on data fusion between optical and radar sensors data, for a tactical lightweight surveillance UAV (MTOW<25Kg). The problem of non-cooperative collision avoidance is well known in literature and is currently a central theme of investigation within the aeronautical industry, considering the growing UAV traffic and the consequent need to employ autonomous self-separation technologies in the market. Several past works have investigated the most varied solutions for the Sense problem utilizing optical, acoustic, electro-magnetic signals or a combination of the previous. Likewise, the Avoidance problem has been successfully tackled in literature by means of a wide variety of different approaches ranging from rule-based methods, strategies based on game theory, force field methods, optimization frameworks leveraging genetic algorithms and nonlinear programming techniques and geometric methods. Yet, to the knowledge of the authors, no previous work found in literature has successfully demonstrated and validated the real-time simultaneous interaction of both sense and avoid functionalities within a highly integrated simulation environment. The present work describes the implementation of a complex, nonlinear, simulation environment conceived in order to perform real-time, Hardware-in-the-Loop (HIL), testing of the effective cooperation between sense and the avoid algorithms constituting the core of the SAA system developed within the context of the project. The system effectiveness has been validated by means of complex dynamic simulations, comprising an accurate, fully nonlinear, flight mechanic model of the aircraft, a graphic rendering engine of the scene, proper video capture and transmission pipelines, computer vision algorithms and collision avoidance logics running on the target hardware (Nvidia Jetson Nano) and tailored noise resilient data fusion algorithms. Results show the effectiveness of the system in detecting impending collisions and performing last-resort resolution manoeuvres with high computational efficiency and update frequencies compatible with real world applications in Unmanned Aircraft Systems (UAS).
Target localization with a distributed Kalman filter over a network of UAVs
Authors: Bassolillo S.
Published: October 2023

Abstract. Unmanned Aerial Vehicles (UAVs) have gained significant usage in various kinds of missions, including reconnaissance, search and rescue, and military operations. In rescue missions, timely detection of missing persons after avalanches is crucial for increasing the chances of saving lives. Using UAVs in such scenarios offers benefits such as reducing risks for rescuers and accelerating search efforts. Employing a formation of multiple drones can effectively cover a larger area and expedite the process. However, the challenge lies in achieving autonomous and scalable systems, as drones are typically operated on a one-to-one basis, requiring a large team of rescuers. To enhance situational awareness and distribute communication load, this paper proposes a decentralized Kalman filtering algorithm that exploits sensor data from multiple drones to estimate target positions and support guidance and control algorithms. The algorithm combines Consensus on Information and Consensus on Measurements techniques. Preliminary validation is conducted through numerical simulations in a sample scenario.
Hybrid graph-clothoid based path planning for a fixed wing aircraft
Authors: Blasi L.
Published: October 2023

Abstract. Planning of safe and efficient trajectories is a critical task in the operation of unmanned aerial vehicles (UAVs), especially in urban or complex environments. With the increasing use of UAVs for various applications, such as surveillance, delivery, and inspection, it is becoming more important to automatically generate collision-free paths that also consider aircraft dynamics. This paper proposes an algorithmic approach based on the Rapidly exploring random tree (RRT) algorithm combined with a clothoid-based smoothing procedure to account for aircraft performance.
Multidisciplinary design, analysis and optimization of fixed-wing airborne wind energy systems
Authors: Trevisi F.
Published: October 2023

Abstract. Airborne wind energy (AWE) is the second generation of wind energy systems, an innovative technology which accesses the large untapped wind resource potential at high altitudes. It enables to harvest wind power at lower carbon intensity and, eventually, at lower costs compared to conventional wind technologies. The design of such systems is still uncertain and companies and research institutions are focusing on multiple concepts. To explore the design space, a new multidisciplinary design, analysis and optimization framework for fixed-wing airborne wind energy systems (T-GliDe) is being developed. In this work, the framework of T-GliDe and its problem formulation are introduced.
Multi-step ice accretion on complex three-dimensional geometries
Authors: Donizetti A.
Published: October 2023

Abstract. This work presents the Politecnico di Milano Icing Research Group's contribution to developing new numerical tools and methodologies for simulating long-term in-flight icing over complex three-dimensional geometries. PoliMIce is an in-house ice accretion software that includes state-of-the-art solvers for the dispersed phase to compute the droplets’ impact on the aircraft, and ice accretion models, including the exact local solution of the unsteady Stefan problem. PoliMIce has also been extensively developed for the simulation and robust design optimization of thermal ice protection systems. A crucial aspect that characterizes and makes numerical simulations challenging is the formation, and evolution in time of complex ice geometries, resulting from the ice accretion over the body surface and/or previously formed ice. A multi-step procedure is implemented since the aerodynamic flow field is coupled with ice accretion. The total icing exposure time is subdivided into smaller time steps. At each time step, a three-dimensional body-fitted mesh suitable for the computation of the aerodynamic flow field around the updated geometry is generated automatically. The novel remeshing procedure is based on an implicit domain representation of the ice-air interface through a level-set method and Delaunay triangulation to generate a new conformal body-fitted mesh. In this work, the unique capabilities of the PoliMIce suite are employed to perform automatic multi-step ice accretion simulations over a swept wing in glaze ice conditions. Numerical simulations are hence compared with the available experimental data.
Development of a DNS solver for compressible flows in generalized curvilinear coordinates
Authors: Soldati G.
Published: October 2023

Abstract. We present a solver for DNS of turbulent compressible flows over arbitrary shaped geometries. The code solves the compressible Navier-Stokes equations in a generalized curvilinear coordinates system, using high-order central finite-difference schemes combined with WENO reconstruction for shock-waves treatment. An innovative stabilization strategy for central schemes based on skew-symmetric-like splitting of convective derivatives is used. The code is oriented to modern HPC platforms thanks to MPI parallelization and the ability to run on GPU architectures. The robustness and accuracy of the present code is assessed both in the low-subsonic case and in the supersonic case. We show here the results of a turbulent curved channel flow and a turbulent supersonic compression ramp, which proved to be in excellent match with previous studies.
Virtual testing application to ESA micro vibrations measurement system
Authors: Dozio L.
Published: October 2023

Abstract. The challenging application of Virtual Testing (VT) to ESA’s six-degree-of-freedom Micro Vibrations Measurement System (MVMS) is described in this work. The digital replicate of MVMS is first obtained from a high-fidelity finite element model, whose order is later appropriately reduced. A state-space model representative of the dynamic behaviour of the MVMS is finally obtained. MVMS VT simulations are thus exploited as a key enabling technology to perform the ad-hoc design of MVMS control system design. This work focuses on different model-order reduction techniques applied to MVMS, which were evaluated and compared in terms of performance and computational issues. Classical and more recent approaches belonging to the family of Component Mode Synthesis (CMS) methods are addressed. State-space based techniques are considered as well, also in two-stage combination with CMS methods. Challenges and advantages of VT are lastly discussed.
BEA: Overview of a multi-unmanned vehicle system for diver assistance
Authors: Barilaro L.
Published: October 2023

Abstract. This paper presents an overview of a solution to address the issue of marine traffic endangering scuba diving and free diving. Diving is a popular recreational activity, and it is estimated that there are around six million active scuba divers worldwide. When diving, it is essential to signal one's presence with universal markers, however, boat drivers do not always recognize them and can speed too close to dive zones, posing a risk to divers. To mitigate these risks, a multi-unmanned vehicle system consisting of an Unmanned Aerial Vehicle (UAV), an Unmanned Surface Vehicle (USV), and an Unmanned Underwater Vehicle (UUV) has been developed. The proposed system works in synergy to monitor and protect divers. The UAV monitors the surface of the sea near the dive zone for any traffic, while the USV tracks the UUV, communicates with the other unmanned vehicles, and provides a takeoff/landing surface for the UAV. The USV can also be used to tow divers and equipment to/from the shore. Finally, the UUV tracks the diver and warns them if it is unsafe to surface. The paper provides an overview of the design and system's architecture, algorithms for boat detection, precision landing and UUV tracking, as well as preliminary tests carried out on the prototype. The proposed system is found to be suitable for the intended application. The BEA (Buoy Eau Air) system is the first in the world to use a multi-drone system to create a geo-fence around the diver and monitor the area within it. The paper also highlights the potential benefits of such a system for the touristic sector, especially for countries where diving is a popular recreational activity.
Italian space agency space transportation activities and programs
Authors: Albano M.
Published: October 2023

Abstract Space transportation systems are the key elements for the space exploitation thought space-based services (for telecommunication, navigation and earth observation) and space exploration. As more government and commercial players show interest in effective and sustainable space transportation systems and services, affordable, regular and resilient transportation systems have become increasingly important for sustainable space services. Italy, thought the activities of the Italian Space Agency, is increasingly investing in the space sector and it confirms to be one of the top players on the international scenario. The paper presents an overview of the activities of the Italian Space Agency in this sector, both through national and European framework.
Acoustic characteristics evaluation of an innovative metamaterial obtained through 3D printing technique
Authors: Cardone L.M.
Published: October 2023

Abstract. The reduction of interior noise level in the transportation sector is a big problem to cope with in view to increase the comfort of passengers. For this reason a great emphasis from the research community is devoted to develop new technology which are able to satisfy the mechanical requirements with concrete benefits from the acoustic point of view. Currently, it does not exist a solution for wideband range of frequency. Indeed, porous materials are characterized by outstanding dissipation in the high frequency range but they exhibit poor performance in the low and medium frequency range, where instead resonant cavities systems have the best performances but with narrow-band sound absorption. For this reason, the design and development of new materials which offers a good acoustic absorption over a wide range of frequencies is requested. In this paper, a hybrid metamaterial is designed, by coupling resonant cavities with micro-porous material and obtained through additive manufacturing technique which enables to model complex geometries that could not be feasible with classical manufacturing. Numerical and experimental studies have been conducted on the manufactured samples of PLA, with an interesting focus on the effect of each parameter which affects the absorption properties.
Wind tunnel flutter tests of a strut-braced high aspect ratio wing
Authors: Marchetti L.
Published: October 2023

Abstract. Increasing the wing aspect ratio is one way to improve aircraft aerodynamic efficiency. This reduces the induced drag term but, at the same time, produces an increment of the wing loads, hence an increase of the structural weight. One design solution to reduce the wing root bending moment, which is the main driver of the weight of the wing, is the addition of a strut. This work deals with the experimental identification of the flutter behavior of an ultra-high aspect ratio (19) strut-braced wing in a wind tunnel. The inherent non-linear behavior of such a structure that has two different effects on the wing when loaded in compression and in tension is coupled with large deformations due to its extreme flexibility. From here derives the extreme importance of experimental tests to understand how different parameters of such a design can impact its aeroelastic behavior.
Improvements in on-board systems design for advanced sustainable air mobility
Authors: Conte C.
Published: October 2023

Abstract. This paper describes the activity proposed in the context of National Center for Sustainable Mobility (CN MOST) for designing an advanced core Guidance, Navigation, and Control system together with an effective on-board systems configuration for sustainable air mobility. A Model Based Systems Engineering strategy is adopted to support the design and development phases. The introduction of new sustainability objectives and the U-Space services to support the integration of unmanned air vehicles in the traditional Air Traffic Management drives the need of a full redesign of on-board systems that must be interfaced with different air platform categories. High performance processing units are considered for embedded systems, including but not limited to machine learning based, image processing and data fusion algorithms for advanced navigation. Three use-cases are presented as reference platform and mission types for validating the proposed systems configuration, specifically unmanned electric Vertical Take Off and Landing aircraft, fully electric general aviation aircraft, and hybrid-electric regional aircraft.
influence of work motivation and job satisfaction on employee performance in the regional office of the directorate general of customs and excise of east Kalimantan
Authors: Adinegara Dedy Anugerah Rinaldy , Perizade Badia , Zunaidah Zunaidah , Widiyanti Marlina
Published: October 2023

This research aims to determine and analyze the influence of work motivation and job satisfaction on the performance of employees at the Regional Office of the Directorate General of Customs and Excise East Kalimantan (Kanwil DJBC Kalbagtim). The data used in this study are primary data collected through the use of a questionnaire as an instrument to measure the research variables. The questionnaire was distributed to all employees of Kanwil DJBC Kalbagtim, totaling 71 individuals, using a census method. The data collected from the questionnaire instruments were processed using the SPSS program with multiple linear regression analysis. The study results indicate that the relationship between work motivation is positively and significantly related to the performance of employees at Kanwil DJBC Kalbagtim, and the relationship between job satisfaction is positively and significantly associated with the performance of employees at Kanwil DJBC Kalbagtim. The findings of this research are used as input for Kanwil DJBC Kalbagtim to enhance employee performance by providing work motivation, such as increasing employee involvement in formal/informal office activities and by paying attention to employee job satisfaction through opportunities for self-development, fair promotions based on employee competencies, and in line with organizational needs.
PERTIMBANGAN PEMBERIAN PENGURANGAN PAJAK BPHTB PADA PANDEMI COVID-19
Authors: Rozi Raja Mohamad , Nisya Nisya
Published: October 2023

Tax is an obligatory contribution of the people to the state which functions to finance all public interests, including finance development to aims for the welfare of the people. The current condition of the Covid 19 pandemic provides a responsive idea to provide taxpayers with “relief” as regulated in Governor Regulation Number 103 of 2011 concerning Granting of Deductions, Relief and Exemption of Duty on Acquiring Rights on Land and Buildings (BPHTB). Pro contra arise in relation to criteria issue for granting relief conflicting regulations with the legal concept of the phrase "economic and / or financial crisis and natural disasters", as stipulated in the provisions of Article 3 paragraph (1), (2) points a and b as well as paragraph (3). In this regard, this article will discuss several things, including: How is the provision of tax breaks in certain circumstances such as "economic and / or financial crisis and natural disasters"? From the results of the discussion, severalthings were found: (1) The argument which is alleged to be the legal reason for not granting relief is derived from the “tax debt write-off doctrine” where that doctrine has been normalized in Article 1381 of the Civil Code; (2) The provisions of Article 3 paragraph (1) and paragraph (2) points a and b The phrase "economic and / or financial crises and natural disasters" regulate different customs, so that the pandemic-19 variable is not regulated in the two articles as a natural disaster. which caused theeconomic crisis, meaning that there was a lack of rules; and paragraph (3) The governor has the authority to regulate and interpret the situation. Conclusion: The absence of the meaning of the Covid-19 pandemic as a natural disaster that causes an economic crisis and / or in the BPHTB tax provisions, must be arranged to be approached with the grammatical interpretation method (denotative) seeing the meaning of the dictionary and the teleological interpretation method to provide an explanation for the interpretation of the DKI Jakarta Governor Regulation on BPHTB Tax which has no official means of explanation. Recommendation: BPHTB tax discount can be given to individual / corporate taxpayers according to the time of payment during the pandemic, first 50% atthe beginning, 30% in the middle and 10% at the end of the pandemic period to ensure justice and legal certainty.
Pengaturan Perizinan Berusaha Pemerintah Kota Batam Sebelum dan Sesudah UU Cipta Kerja
Authors: Pangesti Shinta
Published: October 2023

In the new normal era, the impact of the Covid-19 pandemic is still very much felt, especially in the economic sector. In line with the investment recovery agenda in Indonesia, the Government has taken steps to simplify regulations, one of which is in managing business permits as mandated by the Job Creation Law and its implementing regulations. In order to obtain a comparison of business licensing arrangements in Batam City before and after the enactment of the Job Creation Law, the author examines how business licensing arrangements in Batam City are reviewed from the Mayor of Batam No. 40/2020 jo. Batam Mayor Regulation no. 56/2020 jis. Job Creation Law jo. PP No. 5/2021 jo. PP No. 6/2021? This research is normative legal research using primary, secondary and non-legal legal materials. Because the new Batam mayoral regulations regarding business licensing have not yet been established, the existing old provisions remain in effect as long as they have not been revoked. Adjustment of mayor regulations to the provisions in PP no. 5/2021 jo. PP No. 6/2021 needs to be implemented immediately to realize legal certainty in business licensing.
Comparing Early Modern Colonial Laws
Authors: Hannula Henri , Ribeiro da Silva Júnior Airton , Zatelli Gustavo , Pihlajamäki Heikki
Published: October 2023

Thearticle presents the research group CoCoLaw (Comparing Early Modern ColonialLaws) to the general academic public. In short, the article will present anoutline of the activities,  research interests (especially thoserelated to the matter of this journal’s issue), and the objectives of CoCoLaw.The article is divided into three sections. The first section presents thegroup and its research, whereas the second explains the connection betweenstudies on “police” or “police regulation,” and the proposal to study “coloniallaw” in early modernity. The third section offers a view of the next steps ofdigitalization and the creation of a database.
IMPROVING CRITICAL THINKING ABILITY AND BIOLOGY LEARNING OUTCOMES IN SENIOR HIGH SCHOOL WITH THE SCIENCE TECHNOLOGY AND SOCIETY APPROACH WITH THE ASSISTANCE OF E-LKPD
Authors: Yuniastuti Nanik
Published: October 2023

The aim of this research is to explain the application of the STS (Science, Technology, and Society) approach with the assistance of E-LKPD to improve critical thinking skills and Biology learning outcomes for class XI PMIIA5 students on immune system material at SMA Negeri 2 Yogyakarta in the 2020/2021 academic year. The type of research carried out is Classroom Action Research (CAR) which follows the model of Stephen Kemmis and Robin McTaggart, through the stages of planning, action, observation, and reflection (reflecting). The approach of Science, Technology, and Society Assisted by E-LKPD is carried out by following stages 1) invitation; 2) exploration (exploration); 3) explanations and solutions (proposing explanations and solutions); and 4) taking action. The results of the action showed that all indicators of critical thinking skills increased in cycle 2. The average indicator of critical thinking skills increased by 0.14 points from 2.89 to 3.03 in cycle 2. The indicator of rejecting incorrect and irrelevant information increased from 3.14 to 3.25 in cycle 2. The indicator of detecting and correcting conceptual errors increased from 2.77 to 2.83 in cycle 2. The indicator of seeking new solutions increased from 2.64 to 2.96 in cycle 2. While the indicator made a decision or conclusion after collecting the facts increased from 3.01 to 3.08 in cycle 2. Learning outcomes data showed that the average value of student evaluation increased by 12.37 points from 62.8 to 75.17 in cycle 2. The percentage of class completeness increased by 44 points from 33% to 77% in cycle 2. While the percentage of class incompleteness decreased by 44 points from 67% to 23% in cycle 2. In general, the average value of all poster assessment indicators increased by 1.23 points from 94.7 7 becomes 96.00 in cycle 2.
PENGARUH PEMBELAJARAN BIOLOGI BERBASIS SOCIO SCIENTIFIC ISSUES (SSI) TERHADAP LITERASI KESEHATAN SISWA
Authors: Isnaini Azizah Nur , Rahayu Tutiek
Published: October 2023

Penelitian ini bertujuan untuk mengetahui pengaruh penerapan pembelajaran Biologi berbasis socio scientific issues (SSI) topik sistem reproduksi terhadap literasi kesehatan siswa. Penelitian ini menggunakan desain quasi-experiment yang melibatkan dua kelas masing-masing sebagai kelas eksperimen (E) dan kelas kontrol (C). Variabel bebas pada penelitian ini adalah model pembelajaran yang digunakan yaitu socio scientific issues (SSI) untuk kelas eksperimen dan metode pembelajaran cooperative learning STAD untuk kelas kontrol. Variabel terikat pada penelitian ini adalah kemampuan literasi kesehatan siswa. Variabel kontrol dalam penelitian ini adalah samanya pendidik, materi yang diajarkan, alokasi waktu pembelajaran, dan alat evaluasi yang digunakan pada kedua kelas. Data kemampuan literasi kesehatan siswa didapatkan dengan tes dalam bentuk soal uraian dan data keterlaksanaan pembelajaran didapatkan dengan lembar observasi yang telah divalidasi. Teknik analisis data yang digunakan untuk mengetahui pengaruh penerapan pembelajaran berbasis socio scientific issues (SSI) terhadap kemampuan literasi kesehatan siswa adalah paired sample t-test, independent sample t-test, normalitas gain, dan effect size.  Hasil dari penelitian menunjukkan bahwa pembelajaran Biologi berbasis socio scientific issues (SSI) topik sistem reproduksi berpengaruh signifikan terhadap kemampuan literasi kesehatan siswa. Besar pengaruh pembelajaran SSI melalui uji normalitas gain sebesar 0,38 (sedang) dan uji effect size sebesar 2,122 (large effect).
PENGEMBANGAN LEMBAR KEGIATAN PESERTA DIDIK (LKPD) BERBASIS PROBLEM BASED LEARNING (PBL) PADA MATERI SISTEM REGULASI DENGAN ORIENTASI HASIL BELAJAR PESERTA DIDIK SMA N 1 KROYA
Authors: Krisgiyanti Novita Ardian , Pratama Anggi Tias
Published: October 2023

Abstrak. Penelitian ini bertujuan untuk mengetahui karakteristik, kelayakan, kepraktisan, dan efektivitas dari Pengembangan Lembar Kegiatan Peserta Didik (LKPD) Berbasis Problem Based Learning (PBL) Pada Materi Sistem Regulasi dengan Orientasi Hasil Belajar Peserta Didik SMA N 1 Kroya. Penelitian ini merupakan penelitian research and development (RnD) dengan menggunakan model 4-D. Populasi penelitian merupakan seluruh peserta didik kelas XI MIPA di SMA Negeri 1 Kroya. Sampel penelitian yang diambil sebanyak satu kelas yaitu kelas XI MIPA 1 berjumlah 36 siswa. Instrumen yang digunakan berupa lembar uji validitas, uji kepraktisan, dan uji keefektivan dengan menggunakan hasil pretest dan posttest. Berdasarkan penelitian yang telah dilakukan, dihasilkan produk berupa LKPD berbasis model PBL (Problem Based Learning). Hasil dari lembar validasi LKPD menunjukkan kriteria sangat valid dengan persentase 91,7%. Dinyatakan sangat praktis dengan persentase 86,25%. Kemudian dikatakan efektif dengan melihat hasil perolehan N-Gain yang dihitung menggunakan SPSS didapatkan kategori efektif 78,0667% dengan nilai mean pada N-Gain score 0,7807. Berdasarkan perolehan data tersebut dapat disimpulkan bahwa LKPD Berbasis Problem Based Learning pada materi Sistem Regulasi dinyatakan valid, praktis, dan efektif untuk digunakan sebagai alat bantu ajar biologi. Kata kunci: LKPD; problem based learning; sistem regulasi