bluuebunny/crossref_metadata_2025 huggingface dataset:
Trust in Automated Parking Systems
Authors: de Visser Ewart , Phillips Elizabeth , Tenhundfeld Nathan , Donadio Bianca , Barentine Christian , Kim Boyoung , Madison Anna , Ries Anthony , Tossell Chad
Published: July 2022

In two studies, we evaluated the trust and usefulness of automated compared to manual parking using an experimental paradigm and by surveying owners of vehicles with automated parking features. In Study 1, we compared participants' ability to manually park a Tesla Model X and use the Autopark feature to complete perpendicular and parallel parking maneuvers. We investigated differences in parking success and duration, intervention behavior, self-reported levels of trust in and workload associated with the automation, as well as eye and head movements related to monitoring the automation. We found higher levels of trust in the automated parallel parking maneuvers compared to perpendicular parking. The Tesla’s automated perpendicular parking was found to be less efficient than manually executing this maneuver. Study 2 investigated the frequency with which owners of vehicles with automated parking features used those features and probed why they chose not to use them. Vehicle owners reported using their vehicle's autonomous parking features in ways consistent with the empirical findings from Study 1: higher usage rates of autonomous parallel parking. The results from both studies revealed that 1) automated parking is error-prone, 2) drivers nonetheless have calibrated trust in the automated parking system, and 3) the benefits of automated parallel parking surpass those of automated perpendicular parking with the current state of the technology.
Taking Pride in Disability and Geochemistry
Authors: Riches Amy
Published: July 2022

Exploration and personal story concerning disability inclusion in STEM with an emphasis on the field of Geochemistry. Written to celebrate and mark Disability pride month in 2022.
Evaluation Of DnaJ Chaperone as a Potential Vaccine Candidate Using Computational Tools
Authors: BAWA CHHAYA , Dixit Priyanshi , P Preeti , rawal kamal
Published: July 2022

Trypanosomiasis or Chagas disease is a disease quite prevalent in Central America and other South American countries. With the high rate of infection spread over 7 million people in America, along with high number of mortality rate, this disease requires a good preventive vaccine to get eradicated. And for the same, there has been research on various kind of proteins to find the right vaccine candidate. In this paper, we are evaluating the protein DnaJ Chaperone to find out if it is a potential vaccine candidate or not. For evaluation, we procure DnaJ Chaperone protein sequence from NCBI and run through the Vax-Elan pipeline to get the result values. These values are further compared with the prediction tools cut-off values (Prediction tool is a table of tools which has different parameters for deciding the vaccine candidacy). And based on the cut-off value of different tools, we get to find the potential vaccine candidate.
Aktivitas Harian Burung Kakatua Jambul Kuning (Cacatua galerita) di Bontomarannu Education Park
Authors: Ali Nurjamilah Zakiyah
Published: July 2022

Aktivitas adalah serangkaian tindakan yang dibuat oleh individu dan organisme terhadap dirinya sendiri atau lingkungannya yang mencakup sistem atau organisme lain di sekitarnya serta lingkungan fisik (mati). Pengamatan tentang aktivitas harian burung kakatua jambul kuning (Cacatua galerita) belum banyak dikaji sehingga dilakukanlah sebuah penelitian yang bertujuan untuk mengetahui aktivitas harian apa saja yang dilakukan oleh burung kakatua jambul kuning (Cacatua galerita) setiap harinya. Metode yang digunakan adalah metode kualitatif melalui pengamatan secara langsung dengan mengamati segala aktivitasnya. Hasil penelitian menunjukkan bahwa aktivitas harian yang dilakukan yaitu makan, sosial, vokalisasi, bertengger, memanjat, berpindah tempat dan menaikkan jambulnya serta dari hasil wawancara selain dari perilaku tersebut kakatua jambul kuning juga melakukan kegiatan mebersihkandirinya dan perilaku kawin.
Laporan Hasil Observasi SD Pannara Kesulitan Dalam Membaca
Authors: sutfiyarti
Published: July 2022

Catatan terkait dengan laporan hasil observasi SD negeri pannara
Teaching Constructive Replications in the Social Sciences
Authors: Bauer Gerrit , Breznau Nate , Gereke Johanna , Höffler Jan H. , Janz Nicole , Rahal Rima-Maria , Rennstich Joachim Karl , Soiné Hannah
Published: July 2022

The replication crisis in political science and other social and behavioral sciences spawned a credibility revolution, calling for new open science research practices that ensure greater transparency, including pre-registrations, open data and code and open access. Replications of published research are an important element in this revolution as part of the self-correcting process of scientific knowledge production. Simultaneously, replications can be a pedagogical tool for improving student research method skills and introducing them to best research practices via learning-by-doing. The teaching value of replications is still underutilized thus far, and few examples exist of how quantitative replications can be integrated in undergraduate and graduate courses. This article aims to start filling this gap by offering guidance to instructors in designing and teaching replications for students at various levels and disciplines in the social and behavioral sciences, including a supplementary Teaching Companion.
Measuring the postauricular reflex as an indicator of appetitive processing
Authors: Stussi Yoann , Delplanque Sylvain , Sander David
Published: July 2022

The postauricular reflex is a muscular microreflex behind the ear that is elicited by brief and abrupt sounds. Although it is vestigial in humans, it has been shown to have a potentiated response to the eliciting sound during the presentation of stimuli usually considered as pleasant relative to neutral or unpleasant stimuli across different sensory modalities; this response being even more prominent for appetitive stimuli, such as food and erotic images. This reflex can thus serve as a psychophysiological indicator of appetitive processing and could be a valuable tool for food science. Here, we describe a protocol that can be used to measure and analyze the postauricular reflex in humans. Our goal is to provide information on the materials and methods needed to record the postauricular reflex and to illustrate the preprocessing steps and quantification strategies that can be implemented to score this reflex.
Psychological Flexibility across the Lifespan in Dutch adults
Authors: Slot Magdalena , Reijnders Jennifer , Janssens Mayke , Simons Marianne , Lataster Johan , Jacobs Nele
Published: July 2022

Psychological flexibility provides the ability to react upon and adapt to challenges, including thoughts, feelings or events, in a way that is consistent with personal values, thereby enhancing or sustaining wellbeing. The aim of this study is to improve our understanding of age-graded differences in psychological flexibility, by examining the relationship between (subcomponents of) psychological flexibility and age in a Dutch general population sample (N = 1770; Mage (SD) = 55.77 (14.31); 36.3% male and 63.7% female respondents). The results show that an inverted U-shaped model best supported the relationship between psychological flexibility and age, with an estimated peak at 59.44 years. For the subcomponents of psychological flexibility different patterns were observed. Demographic variables (education, marital status, employment) and positive affect played a significant role. The results have practical implication, especially valuable in our modern society with current challenges (for example covid-19, increasing digitalization).
The perception of artificial-intelligence (AI) based synthesized speech in younger and older adults
Authors: Herrmann Bjorn
Published: July 2022

Artificial intelligence (AI) based synthesized speech has become almost human-like, ubiquitous in everyday live (e.g., smart phones, grocery self-checkouts), and relatively easy to synthesize. This opens opportunities to use AI speech in research and clinical areas, such as hearing sciences, audiology, and speech pathology, where recordings of speech materials by voice actors can be time- and cost-intensive. However, much research thus far has focused on technological developments towards more human-like voices evaluated by younger adults. How older adults perceive AI speech is unclear. Using Google’s Wavenet text-to-speech synthesizer, the current study explores whether AI speech can be used to investigate common speech-in-noise perception phenomena in younger and older adults. Speech intelligibility was recorded for human speech and synthesized speech masked by a modulated or an unmodulated multi-talker babble noise. For both human and AI speech, speech intelligibility was better for the modulated than the unmodulated masker (masking release), and this masking-release benefit was reduced in older adults. Release from masking effects were comparable between human and AI speech, suggesting that modern AI speech could be useful for hearing and speech research. The data further suggest that older adults recognize the presentation of AI speech less frequently, rate AI speech as more natural, and are less able to discriminate between human and AI speech compared to younger adults. Research on speech perception in older adults may thus especially benefit from modern AI-based synthesized speech because, to them, AI speech feels much like spoken by a human.
Directions for Open Scholarship in Autism – Embracing Open Scholarship to Meaningfully Improve Lives of Autistic People Together
Authors: Yeung Siu Kit
Published: July 2022

In recent years, there have been many criticisms in the Autism field, including very low transparency (Bottema-Beutel & Crowley, 2021), biases in research and education, epistemic injustice (Botha, 2021; Milton, 2014; Sandbank et al., 2020), misalignments between community priorities and research (Pellicano et al., 2014), insufficient research with underserved populations (Hoekstra, 2022), lack of diversity and inclusivity (Elsherif et al., 2022), and repetitive replication failures (Gernsbacher & Yergeau, 2019). Discussions and implementations of Open Scholarship are uncommon and lagging in the Autism world. Open Scholarship aims to improve openness, transparency, reproducibility, and replicability, reduce biases, and promote social justice, diversity, equity, and inclusion (Parsons et al., 2022). Concrete possible solutions and rooms for improvement to various problems, based on Open Scholarship, are discussed comprehensively in the contexts of interventions, experiments, meta-analyses, replications, participatory research, lived experience of Autistic researchers, Big Team Science, adversarial and reconciling collaborations, Universal Design, incorporation of Neurodiversity perspectives in education, Open Scholarship Education, and Replication Education. Through embracing and practicing Open Scholarship in various arenas with different stakeholders, quality and impact of Autism research, education, and training will likely increase substantially, hopefully bettering lives of Autistic people meaningfully in the future.
The Dialectics of Patriarchal Chauvinism in Susan Glaspell’s Trifles: A Feminist Study
Authors: Neupane Dipesh
Published: July 2022

Feminist critics always champion and cherish their freedom, equality and justice in social status against patriarchal domination. In many societies, males consider themselves superior to females in terms of social, economic, cultural, physical and political status. They are engaged in social activities leaving the women to content themselves with household chores, children and other frivolous activities. This paper explores, how females get dominated in the play Trifles . The dramatic tension in the play arises when men have legal interest whereas the women only collect the trivial things to unravel the murder mystery of Mr. Wright. Men do not care about the trivial things that females always focus in the play. Instead, they mock and laugh at the females’ interest on trivial things. This research employs the feminist criticism proposed by Helen Pankhurst as the conceptual frame work to invigorate the study. She supports women’s rights on the grounds of equality between the genders, meaning that women should receive the same opportunities, rights, authority and treatment as men. It answers the questions: “How are female characters dominated in the play Trifles? and what might be the ultimate consequences of utter male domination in the family?” Overtly or covertly, females always intend to subvert the patriarchal chauvinism through their rebellious activities in the family and society.
Toni Morrison’s Beloved: A Study on History, Slavery and Love
Authors: Dhakal Lekha Nath
Published: July 2022

This article makes an effort to describe Toni Morrison’s novel, Beloved as a fusion of History, slavery and love. It also reveals that history of Afro-Americans, slave narrative; love and fantasy are the main assets of the novel. In the novel, she focuses on the horror of the past so that Afro-Americans and the Americans all those who involved with slavery would come face to face with grim reality of the past and rise above it. The novel articulates and embodies a history of slavery of African-Americans and their experiences, which has been apparently, accurately and carefully recovered but is actually uncooked. Beloved directly confronts racism which combines lyrical beauty with an assault on the readers’ emotions and conscience. It emphasizes the legacy of slavery using forms resulting from traditional Back Folk aesthetic. It deals with the life and history of Black American women immediately after the emancipation of slaves in the North. Beloved also presents a tragedy involving mother’s moment of choice, and a love story exploring what it means to be beloved. Thus the novel holds the key to the narrative’s unity. The subject matter is stressful to read and it is also confrontational and painful. The form combines historical realism with magic, slavery and love.
Research Data Management needs assessment of Clemson University
Authors: Sheffield Megan , Burton Karen B
Published: July 2022

Research data management (RDM) encompasses a wide range of activities that include documenting and managing data during a research project, as well as sharing and preserving data after the research project is completed.  Academic libraries can offer a variety of services that support researchers during the research life cycle which vary among institutions.   The faculty, staff, and graduate students of Clemson University were surveyed by Clemson Libraries about their research data management (RDM) needs in the spring of 2021.  The survey was based on previous surveys from 2012 and 2016 to allow for comparison, but language was updated and additional questions added because the field of RDM has evolved.  Survey findings indicated researchers are overall more likely to back up and share their data, but the process of cleaning and preparing the data for sharing was an obstacle.  Few researchers reported including metadata when sharing, or consulting the library for help writing a Data Management Plan (DMP).  Researchers want RDM resources, and offering and effectively marketing those resources will enable libraries to both support researchers and encourage best practices. Understanding researcher needs and offering time-saving services and convenient training options makes following RDM best practices easier for researchers.  Communicating how RDM benefits researchers and integrating RDS into the research life cycle through partnerships is crucial for ensuring effective data management.
Sosialisasi Dampak Kecanduan Penggunaan Gadget Bagi Kehidupan Anak Sekolah di SMP Fransiskus Semarang
Authors: Dewi Widya Novi Angga , Marini Marini , Khasanah Khasanah , Rifandi Raditya Ahmad
Published: July 2022

Hampir setiap orang yang memanfaatkan gadget menghabiskan banyak waktu mereka dalam sehari untuk menggunakan gadget. Oleh karenanya gadget juga memiliki nilai dan manfaat tersendiri bagi kalangan orang tertentu. Akan tetapi banyak dampak negatif yang muncul dalam pemanfaatan gadget bagi kalangan remaja, anak, bahkan balita. Tujuan pengabdian ini yaitu untuk meningkatkan pemahaman siswa dan guru dalam penggunaan gadget. Metode pengabdian dilakukan dengan penyuluhan, diskusi, dan pendampingan. Adapun hasil pengabdian diperoleh bahwa penyuluhan dan pendampingan yang disertai diskusi terhadap guru dan peserta didik di SMP Fransiskus Semarang berdampak positif terhadap pemahaman dan sikap siswa dalam penggunaan gadget.
Kontribusi Mahasiswa untuk Menunjang Adaptasi Teknologi di SD N Kedungpane 01 Kota Semarang dalam Program Kampus Mengajar
Authors: Pristya Devy Maharja , Febriansyah Mohammad Rizky , Fachruddin Amirullah Erza , Trisetiyanto Adi Nova
Published: July 2022

Kampus Mengajar salah satu program Kemendikbud-dikti yang befokus pada peningkatan kualitas pendidikan sekolah dasar dan sekolah menengah yang berada di wilayah 3T ataupun yang masih ber akreditasi C. Program ini bertujuan untuk memfasilitasi mahasiswa untuk berkontribusi di dalam pendidikan di tingkat sekolah dasar dan sekolah menengah pertama, di bawah bimbingan dosen pembimbing lapangan. Kampus mengajar Angkatan 2 di SD Negeri Kedungpane 01, Kecamatan Mijen, Kota  Semarang, Provinsi Jawa Tengah dilaksanakan oleh enam mahasiswa dari perguruan tinggi yang berbeda dengan 1 dosen pembimbing. metode penelitian yang dilakukani yaitu abservasi, wawancara dan analisis dari program. Kegiatan ini meliputi mengajar, membantu adaptasi teknologi serta membantu administrasi sekolah dan guru. Kegiatan mengajar dilakukan dalam bentuk program pendampingan KBM, Home Visit, pendampingan AKM, praktik kegiatan literasi numerasi serta jum’at SKG dan sebagainya. Program adaptasi teknologi dan membantu administrasi dalam bentuk kegiatan pengenalan teknologi AKSI, sosialisasi pembuatan media pembelajaran berbasis teknologi, membantu administrasi sekolah, administrasi guru dan administrasi perpustakaan tujuan penelitian guna mengetahui keberhasilan dari masing-masing tiap program.
What Factors Influence the Perceptions of Job Satisfaction in Registered Veterinary Nurses Currently Working in Veterinary Practice in the United Kingdom?
Authors: Vivian Sarah R. , Holt Susan L. , Williams Jane
Published: July 2022

The Royal College of Veterinary Surgeons is dedicated to empowering registered veterinary nurses (RVNs) and ensuring that they are valued members of the workforce within the United Kingdom. However, this is not always reported by the RVNs themselves, who state that although they derive satisfaction from working with animals and within a profession that makes a difference, there are areas in which they are not currently satisfied, such as pay scale and recognition. Responses to a questionnaire were analyzed using a mixed-methods design to determine current factors affecting job satisfaction utilizing a deductive and inductive approach. The questionnaire reached 205 RVNs currently working in practice within the UK; respondents were divided between remaining at their current practice ( n = 101) and finding alternative employment ( n = 80). Those who stated that they were happy in their job role were more likely to want to remain there. Themes relating to positive and negative job satisfaction were reported and used to devise strategies employers and employees could use to increase or maintain RVNs’ overall satisfaction. More focus is needed on support and communication within veterinary practices, support for appropriate delegation linked to recognition of the RVN role, and support from educators to prepare students for the RVN role. Although the questionnaire did not reach the targeted sample size, responses agree with previous data indicating that changes made to the RVN role in the UK have not sufficiently improved job satisfaction scores.
Tendency for change of agroclimatic conditions for formation of millet yield by 2050 within the Steppe zone of Ukraine
Authors: Lyashenko H. V. , Danilova N. V. , Kolosovska V. V. , Tolmachova A. V.
Published: July 2022

The current trend of climate change requires a significant revision of the species and breed composition of agricultural crops. Preference should be given to drought-resistant crops such as millet, especially in the Steppe zone of Ukraine. Thus studies of agro-climatic conditions for formation of millet yields in the coming years are of great importance. The article covers the assessment of changes in agro-climatic resources for the northern and Southern Steppe zones of Ukraine according to RCP4.5 and RCP8.5 scenarios during three ten-year periods: 2021-2030, 2031-2040 and 2041-2050 as compared with the basic period of 1986-2005. The research applies the basic model for assessment of agro-climatic resources of formation of agricultural crops productivity developed by A. M. Polevoy. The model uses meteorological and agrometeorological data of air temperature and humidity, precipitation, solar radiation, water-physical properties and soil moisture obtained through standard meteorological and agrometeorological observations. The model of crops production process allowed establishing the agro-climatic resources during millet vegetation season and indicators of photosynthetic productivity, as well as determining the regularities for formation of different agri-environmental categories of crop yield and crop yield fluctuations under climate change within the thirty-year period from 2021 to 2050. The research evaluates the change of aforementioned indicators both in the context of individual periods and in the context of the Northern and Southern Steppe zones. It was found that the largest change in agro-climatic resources and millet productivity is observed in the Southern Steppe zone. For both the Southern and Northern Steppe zones the largest difference of such indicators is observed under the RCP8.5 climate change scenario. It was also found that the largest change of the indicators is observed within the period from 2031 to 2040. However, within the next decade, the values of all indicators will be close to the data observed during the basic period (1986-2005). According to the results of calculations for the period from 2021 to 2050 under RCP4.5 and RCP8.5 scenarios the expected scenario yields will be higher than those of the basic period.
STRUCTURAL FEATURES OF THE WALL OF MYOCARDIAL INTRAMURAL VESSELS AND THE CONTENT OF HOMOCYSTEIN IN THE BLOOD PLASMA UNDER THE LINDANE AND SODIUM DICHROMATE EXPOSURE
Authors:   West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan, Rakhmanov S.B. , Elyasin P.A. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Balmagambetova A.D. ,   West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan, Zhanabaeva A.B. ,   West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan, Zhumabaj N.A. ,   West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan
Published: July 2022

Aim. Determine indicators of the vascular wall of the ventricular myocardium and the level of homocysteine in the blood when exposed to sodium dichromate and lindane under experimental conditions. Methods of the Research. The experiment was carried out on male mice; the histological method, morphometry of the obtained data, biochemichal blood analysis, and the statistical processing of the research data were used. Results. When exposed to sodium dichromate in the 1st month of the experiment, the myocardial arteries of the anterior wall of the left ventricle were thickened by 3.8 px compared with the control, in the 2nd month of the experiment this indicator was close to those of the control group. When compared between the two experimental groups, no clear changes were found. The revealed changes in the myocardial artery of the posterior wall of the left ventricle are similar to those of the anterior wall artery. The content of homocysteine under the exposure to sodium dichromate in the 1st month is higher, in the 2nd month of the experiment it is slightly reduced compared to the 1st month. The data obtained in the lindane treatment group both in the 1st and 2nd months of the experiment were close to those of the control group. Conclusion. Chronic exposure to sodium dichromate and lindane causes thickening of the walls of the intramural arteries, which was accompanied by an increase in the level of the endothelial dysfunction marker — homocysteine in the blood, while increasing further damage to the walls of the arteries in the myocardium.
EPIDEMIOLOGY AND EPIDEMIOLOGICAL RESEARCH METHOD: HISTORY, CHARACTERISTICS, PROSPECTS
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Semenova V.N. , Fedyanin A.P. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Krasheninina G.I. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Fedyanina N.S. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Galuzo N.A. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Nikiforova N.G. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Stepanova A.E. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: July 2022

Based on the analysis of the literature and our own ideas using general logical methods of analysis and synthesis, information is presented on the advisability of a broad interpretation of the content of the term "epidemiology", which at the present stage includes two sections with a uniform research methodology: the epidemiology of infectious diseases and the epidemiology of non-infectious diseases. The features that distinguish the epidemiology of non-communicable diseases from classical infectious epidemiology are shown. Attention is paid to evidence-based medicine, the theoretical basis of which is clinical epidemiology. Proposals on the need to introduce a course of epidemiology of non-infectious pathology into the educational process of training specialists in biomedical profile are substantiated as a perspective of epidemiology and the epidemiological method of research in modern conditions.
SURGICAL TREATMENT FOR PELVIC DYSTOPIA OF THE LEFT HYPOPLASTIC KIDNEY WITH VAGINAL ECTOPIA OF THE URETER
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Feofilov I.V. ,   State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia, Shkuratov S.S. ,   Novosibirsk State Medical University, Novosibirsk, Russia; State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia, Pochivalov A.K. ,   Novosibirsk State Medical University, Novosibirsk, Russia; State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia
Published: July 2022

Among the anomalies in the development of all organs and systems, congenital malformations of the kidneys and upper urinary tract occupy the first place, accounting for 12.9–40% of all congenital malformations and 3–5.5% of the total number of urological cases. The combination of two or more anomalies of the genitourinary system is extremely rare. The article presents a description of the clinical observation and the choice of surgical treatment for three anomalies in the development of the urinary system, for a long time unrecognized in a 19-year-old patient — pelvic dystopia of the left hypoplastic kidney with vaginal ectopia of the ureter.
RETROSPECTIVE ASSESSMENT OF NON-MOTOR SYMPTOMS IN PARKINSON'S DISEASE
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Vostrikova E.V. , Panyushkina Yu.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Yakusheva A.K. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Pilipenko P.I. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Epalintseva M.A. ,   Medical Center Innovation & Health, Novosibirsk, Russia
Published: July 2022

The article presents the analyzed anamnestic data of 118 patients with Parkinson's disease (40 men and 78 wo¬men). Patients were divided into groups according to the severity of the disease. The number of patients with the first degree of severity was 11 people, with the second — 36 people, with the third — 62 people, with the fourth degree — 9 people. According to the results of the study, it was found that non-motor symptoms were detected before the onset of motor symptoms of Parkinson's disease, and were also present in 100% of patients. Therefore, the understanding of the non-motor symptoms' pathology in this disease, and providing an early, accurate diagnosis and appropriate therapeutic approach at the prodromal stage, remains a major and challenging task in the treatment of Parkinson's disease.
THE USE OF THE ANKITROM GEL IN COMPLEX CORRECTION OF CLINICAL AND FUNCTIONAL MANIFESTATIONS OF VARICOSE VEIN DISEASE
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Drobyshev V.A. , Shpagina L.A. ,   City Clinical Hospital No. 2, Novosibirsk, Russia, Karmanovskaya S.A. ,   City Clinical Hospital No. 2, Novosibirsk, Russia, Shelepova N.V. ,   City Clinical Hospital No. 2, Novosibirsk, Russia, Zaikina E.A. ,   City Clinical Hospital No. 2, Novosibirsk, Russia
Published: July 2022

The study involved 45 men and women aged 35 to 55 years with a verified diagnosis according to the CEAP classification: varicose vein disease, C2, 3s, Ep, As, p, Pr, with complaints of pain, swelling of the lower extremities in the evening, fatigue, signs of varicose dilation of the saphenous veins. The participants were divided into 3 groups: in group 1 (n = 25), the basic treatment complex was optimized by magnetophoresis with chitosan gel Ankitrom with the venom of the Siberian pit viper and taurine on the lower extremities, and the patients were also recommended to apply the gel to the painful areas before going to bed; in group 2 (n = 10), in addition to standard treatment, placebo magnetophoresis procedures were performed; in group 3 (n = 10), in addition to basic therapy, Ankitrom gel was rubbed into the skin of legs and feet in the morning and evening. According to the results of the study, it was found that magnetophoresis with Ankitrom gel on the legs and feet helps to reduce the severity of pain syndrome, reduce the time of systolic blood filling of vessels on the legs and feet by 1.3 times, and increase the rate of emptying of venous vessels of the extremity, as evidenced by the decrease in venous outflow by 1.2 times from the initial values, which significantly differed from similar indicators in the comparison groups.
POSSIBILITIES FOR DIAGNOSIS AND CURATION OF TEMPOROMANDIBULAR JOINT PATHOLOGY GIVEN THE MASTICATORY MUSCLES HYPERTONICITY IN PERSONS WITH SYSTEMIC CONNECTIVE TISSUE DYSPLASIA
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Vereshchagina G.N. , Domshinskaya E.A. ,   Clinic of Dr. Sadykova, Novosibirsk, Russia, Dergilev A.P. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Ilyin A.A. ,   Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia
Published: July 2022

Systemic dysplasia is a formation pathology of the connective tissue structures. With a high prevalence of systemic connective tissue dysplasia (SCTD), the insufficient awareness of doctors about the possibilities of its early diagnosis and correction, starting from the stage of pediatric care, draws attention. Progressive asymmetries of the skeleton already from childhood lead to additional trauma of all genetically determined, but at the same time defective connective tissue structures. The aim of the work was to improve the efficiency of diagnosis and treatment of diseases of the temporomandibular joint (TMJ) in persons with SCTD. The results of a study of 507 patients of different ages are presented. Comparative radiography of the lower extremities reveals a row of pathological changes in the hip and knee joints, the difference in the length of the femurs, lower legs; the height of the iliac wings, scoliosis of the lumbar spine, allowing us to consider them as a complex of Short Leg Syndrome in the framework of SCTD. Asymmetries of the bone structures of the lower jaw are often aggravated by hypertonicity of the masticatory muscles. According to the results of radiological examination, various bone asymmetries of the maxillofacial region (MFR), of the lower extremities within 5–15 mm of relative length, centric jaw relation abnormalities, pathological changes in the masticatory muscles, dislocation of the TMJ articular disc, positional asymmetry of the external auditory canals were revealed. The information obtained allows us to construct a diagnostic algorithm. Ultrasound of the heart, abdominal organs, and kidneys in a standing position were performed to diagnose visceral signs of SCTD. The methods of diagnosis of skeletal asymmetries include: orthopantomography (OPTG) of the MFR, transoral radiography of C1-C2, comparative radiography of the lower extremities, computed tomography and conebeam computed tomography of the MFR capturing the structures of the joint and three upper cervical vertebrae, magnetic resonance imaging of the TMJ. Bone asymmetries are combined with asymmetries of muscle structures, increasing postural imbalance. Multiple anatomical incongruences are aggravated by muscular imbalance in the TMJ biomechanics, which, in the context of systemic connective tissue dysplasia, significantly complicates standard treatment tactics, and worsens the prognosis and remote catamnesis.
THE RELATIONSHIP BETWEEN MICROBIOTA AND MENTAL DISEASES
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Ovchinnikov A.A. , Klimova I.Yu. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Volnaya Yu.S. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: July 2022

Currently, the possible role of intestinal microorganisms in the etiology and pathogenesis of mental illness is being actively studied all over the world. Every year the number of studies is steadily increasing, however, in the Russian-speaking environment, an awareness of this issue and the number of extensive reviews of scientific literature still remain at an insignificant level. The aim of this study is to review and systematize the scientific literature and clinical studies on the impact of the intestinal microbiome on the etiology and pathogenesis of depression, schizophrenia, autism spectrum disorders, Alzheimer's disease, bipolar disorder, and obsessive-compulsive disorder. The actual studies were conducted in sick volunteers and animal models using different approaches: comparison of the composition of the gut microbiota between affected subjects and controls; observation of behavioral changes in affected subjects after administration of pathogenic intestinal microbiota or probiotics. Definite regularities in the change in the qualitative and quantitative composition of the taxonomic units of various microorganisms were revealed.
Communicative and behavioral aspects of the problem of HIV infection and STIs: results of a survey of students in Novosibirsk
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Khryanin А.А. , Marinkin I.O. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Shpiks T.A. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Russkikh M.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Chernikova E.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: July 2022

Introduction. For a long time, sexually transmitted infections (STIs) and HIV infection were considered independently of each other. However, at present, these infections, in addition to similar mechanisms of spread and social causation, are inextricably linked with forms of sexual behavior. Young people are a socially active part of the population, which makes them a risk group for the incidence and spread of STIs and HIV infection. Consequently, analyzing the young p¬eople’s awareness of HIV and STIs is of particular importance. Aim. To assess the characteristics of sexual behavior and the awareness of young people regarding STIs and HIV infection, as well as to study the attitude and degree of readiness to provide medical assistance to HIV-infected patients among students of a medical university. Materials and Methods. We used the data of a sociological survey of young people, performed in the period 2016–2020 among students of higher (medical, pedagogical and transport universities) and secondary specialized educational institutions (College of Hairdressing Art, Faculty of secondary vocational education of the Agrarian University) in Novosibirsk. Results. The sexual behavior of students of higher and secondary specialized (vocational) educational institutions is characterized as risky. The awareness and knowledge about STIs and HIV infection among students in Novosibirsk seems insufficient. The majority of students (69%) of the medical university experiences fear of contracting HIV while providing medical assistance to HIV-infected patients. The level of professional communicative tolerance of future doctors is assessed as high (80%). Conclusion. There is a low awareness of sexual health among young people. The lack of knowledge of the legal aspects of providing medical care to HIV-infected patients revealed in the course of the survey among students of the medical university requires a more detailed study of these issues during the training of future doctors for professional activities.
Current research on the role of the blood-brain barrier in the central nervous system lymphomas development
Authors:   Research Institute of Internal and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia, Voropaeva E.N. , Karpova V.S. ,   Private healthcare institution “Clinical Hospital ‘RZD-Medicine’ Novosibirsk”, Novosibirsk, Russia, Pospelova T.I. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Maksimov V.N. ,   Research Institute of Internal and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia, Vorontsova E.V. ,   Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia
Published: July 2022

The review summarizes modern researches about the role of the blood-brain barrier (BBB) in the development of lymphomas of the central nervous system (CNS). Currently, it has been established that the BBB is a highly active structure. On the one hand, it protects the brain tissue from chemical, physical and other influences, and on the other hand, it is uniquely adapted for transmitting signals between the CNS and other parts of the body. BBB cells respond to signals from the CNS or blood compartments that can stimulate changes in their barrier, transport, and secretory functions. The immune privilege of the CNS is not absolute. Normally, extravasation of lymphocytes through the BBB is crucial for immune surveillance in nervous tissue, although it is tightly regulated. Damage to the BBB is one of the central links in the pathogenesis of many diseases of the nervous system, and the nonspecific permeability of the BBB can increase significantly in various somatic pathologies. In general, immunological dysfunction and inflammation are the main factors in the violation of the BBB integrity. The mechanisms of metastasis of malignant lymphomas in the CNS remain poorly understood, although it is already clear that their implementation requires interactions between circulating tumor cells and BBB components, while some cytokines can act as attractants for metastatic cells, and the process of tumor development includes several stages from extravasation to local proliferation and activation of neoangiogenesis.
Autonomic nervous system antedating response significance in the apparently healthy students under conditions of cognitive load
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Archibasova E.А. , Kulikov V.Yu. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Voevoda M.I. ,   Federal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia
Published: July 2022

Introduction. Anticipating regulatory mechanisms allow a person to more effectively adapt to the impact of environmental factors with the formation of an optimal response structure. Aim. To reveal the features of the antedating response of the autonomic nervous system under conditions of cognitive load in apparently healthy students. Materials and methods. The study involved 30 medical university students aged 18–19 years. The participants were divided into two groups (15 people in each). In group 1, the semantic verbal fluency test was used as a load, in group 2 – the Intelligence Structure Test (IST) by Amthauer. RR intervals in the examined young men were recorded under control and load conditions. The indicators of heart rate variability (HRV) were assessed – RRNN, TP, HF, LF, VLF. Results. Analysis of HRV in group 1 revealed that after exercise, RRNN, TP, HF, and LF indicators significantly decreased; in group 2, after exercise, TP and LF indicators significantly increased relative to control values. Using correlation analysis, we revealed differences between the HRV indicators at the time of preparation for the cognitive test between the studied groups. In group 1, unlike group 2, there was no correlation between RRNN and HF, TP and LF, HF and LF, LF and VLF. After the test in group 1, a significant positive correlation was found between RRNN and HF. In group 2, the correlation relationships between the RRNN and LF indicators were determined, the interaction between HF and LF increased, there were no correlation between the LF and VLF indicators. Differences between the HRV indicators at the time of preparation for the cognitive test showed that the anticipation of the upcoming examination determines the response of the HRV regulatory mechanisms to the action of the load. Conclusion. Different variants of cognitive loads contribute to changes in the activity of the autonomic nervous system in the regulation of HRV. The nature of these changes depends on the initial level of regulatory capabilities of HRV, which determine the antedating response to the cognitive load.
Antecedentes del apego, tipos y modelos operativos internos
Authors: González Santana Sabrina
Published: July 2022

La conceptualización del apego y la explicación teórica que lo avala ha sido una enorme contribución para la comprensión del desarrollo humano, ocupando así un lugar destacado en la historia de la psicología.

Los seres humanos creamos vínculos emocionales; y lo que facilita que se desarrollen y se mantengan lo denominamos representaciones mentales (de uno mismo y de los demás —modelos operativos internos—), ayudándonos así a entender el mundo y reaccionar adecuadamente, a predecir y comprender los sucesos, a iniciar y mantener conductas que favorecen la supervivencia (como el mantenimiento de vínculos) y a sentirnos seguros.

En este capítulo tratamos de abordar cómo surge y ha evolucionado esta teoría, qué tipos de apego existen y se exponen las bases de los modelos operativos internos, núcleo fundamental para la comprensión de la importancia del apego.
Effect of polysaccharide based edible coating to improve shelf ­life and quality of guava (Psidium guajava) in Malwa region of central India
Authors: Rai Pooja , Kanwar Jyoti , Kanpure R. N. , Singh Om , Rathore G. P. S.
Published: July 2022

Guava fruit have a very short shelf life due to high rate of respiration. Storage of guava fruits at room temperature causes weight loss, microbial disease, physiological disorders and physical injuries and is moreover, highly susceptibility to chilling injury making low temperature storage less possible. Therefore, the present investigation was carried out at the Department of Fruit Science, College of Horticulture, Mandsaur, Madhya Pradesh, India during the year 2019- 2020 with an objective to extend shelf-life of guava fruits cv. Rewa-72. The treatments comprised of post-harvest treatments with Chitosan, Carboxymethyl cellulose, Aloe vera gel. The physico-chemical, functional and sensory quality of guava fruits were significantly influenced by application Chitosan @ 1.5% and Carboxymethyl cellulose @ 1.5%) coating up to 12 days of storage. It was found that the CMC or Chitosan bilayer coating was equally effective as the commercial polyethylene wax in enhancing glossy appearance of guava fruits because it is a good moisture barrier, thus preventing the water loss by transpiration. Chitosan @ 1.5% and CMC @1.5% treated fruits had more overall acceptability because this coating helped in improving the colour, aroma, taste, texture, appearance and quality of fruits. Hence, this technology could be more useful for increase shelf life of fruits, low cost and reduce the post-harvest loss of fruits it also helps to replace the use of harmful chemicals by growers and traders.
Integrated nutrient management on the growth, yield, nutrient uptake and soil nutrient status of tomato (Solanum lycopersicum) cv. “Arka Rakshak” under north-eastern ghats region of India
Authors: Charishma K. Vimala , Chatterjee Subhrajyoti , Supriya Tarra , Bera Monisankar , Barman Saurav , Datta Nilanjana
Published: July 2022

Tomato, a heavy nutrient feeder requires large quantities of chemical fertilizers which increased the crop productivity, however, badly affected the soil productivity and environmental quality. This situation demands integration of organic manures without reducing the productivity. Therefore, a field experiment was conducted at M.S. Swaminathan School of Agriculture, Centurion University of Technology and Management, Odisha, India during rabi season of the year 2020-21 to scrutinize the effect of integrated use of organic and inorganic sources of nutrients (INM) on the growth, yield, nutrient availability and soil nutrient status to tomato. Nine nutrient treatments with 100, 75 and 50 % recommended dose of nitrogen (RDN) in combination with vermicompost (VC), farmyard manure (FYM) with biofertilizers viz., Azotobacter and Azospirillum were laid out in randomized block design replicated thrice. The study revealed that the integration of organic manures in combination with inorganic fertilizers significantly improved overall plant growth, yield, nutrient uptake and soil nutrient status of tomato than sole application of the inorganic sources of nutrients. The findings revealed that the treatment 50% RDN + 25% N through VC + 25% N through FYM was superior in terms of all growth and yield parameters under study. However, highest values for all the quality parameters were exhibited by treatment 50% RDN + 50% N through FYM + BF’S. Total nutrient uptake in regard to nitrogen, phosphorus and potassium by tomato plant recorded significantly highest in 50% RDN + 25% N through VC + 25% N through FYM. Similarly, the residual soil fertility in respect to organic carbon, available N, P and K were improved significantly by various treatments and found highest in the treatment 50% RDN + 25% N through VC + 25% N through FYM. Hence, the use of integrated nutrient management becomes indispensable for maximizing tomato yield, sustaining soil health and quality.
Study on the invasive alien species in ponds of Jalaun district of Uttar Pradesh, India
Authors: Yadav V. K. , Sharma Sonam
Published: July 2022

Invasive alien plant species are widely vulnerable to invasion and recognized as stresses altering the ecosystem properties and competing with native flora of pond. During the investigation a total of 30 invasive alien species belonging to 26 genera under 17 families were recorded. Asteraceae was the most dominant family with 5 species and about 79% of these invasive alien species were introduced from Tropical America. Among invase alien species, major potential threat in the near future is by Argemone maxicana and Parthenium histophorus. It was observed that 18 plant species were being used by local inhabitant for medicinal purposes. In order to resist the spread, a better planning is needed for early detection of control, report infestation of spread of new and naturalized invasive alien species to be monitored.