bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Concept of Genetic Preposition to Committing Crimes
Authors: Shestak Viktor , Slivinskaya Nadezhda
Published: July 2024

The article discusses genetic studies of antisocial behavior, in particular in the field of chemical processes occurring in the brain, mental disorders and other processes that prove the presence of a genetic contribution to antisocial behavior, as well as parameters, types of criminal behavior and methods of its determination. The reason for studying the issue was the ongoing debate since the formation of criminology as a science about the relationship between genetics and criminal behavior. The analysis carried out by the authors indicates that the presence of individual genes or a group of genes, as well as an unfavorable environment, can be catalysts for the emergence of certain personal characteristics that increase the likelihood of a person participating in criminal activities. The numerous studies and experiments carried out to date, according to individual experts, allow to eliminate some unknown characteristics associated with the field of biological criminology and genetics, advance the scientific understanding of the criminal mind...
The Hypothesis of the Organization of the “Northern Sea Passage” from the Northern Dvina to the Mouth of the Yenisei for the “Zakamensk silver” and to Mongolia
Authors: Filin Sergey
Published: July 2024

The army of Prince A. Ya. Nevsky in 1256-1257 made the northern polar campaign on skis and sledges and reached the “Kiyan Sea” (the Barents Sea, the region of Murmansk and Northern Norway). As a result of the military campaign, the lands in the Arctic were returned and included in the Novgorod possession and in the general economic, cultural and spiritual connection with the Russian lands. The article substantiates the hypothesis about the organization of the “Northern Sea Passage” from Novgorod to the mouth of the Yenisei for “Zakamensk silver” and, possibly, to Mongolia.
Chinese Consumers' Attitudes Toward Animal Welfare: Behaviors, Beliefs, And Responses To Messaging
Authors: Faunalytics
Published: July 2024

Although China’s per capita meat consumption is lower than most wealthier, Western countries (Ritchie & Roser, 2017), the country’s size and rapid growth of its meat industry means that it houses and slaughters more farmed animals than any other country in the world (Faunalytics, 2022). Despite this, animal welfare remains a relatively fringe issue in China. Because of the scale of China’s agriculture industry, even small changes have the potential for an outsized effect. For this reason, this research uses semi-structured focus groups to understand Chinese consumers' attitudes toward animal welfare with the goal of addressing how to improve outcomes for farmed animals in China. After identifying key findings that include, for example, how Chinese consumers link food quality and higher animal welfare, this report concludes with a variety of recommendations for advocates, alternative protein companies, and researchers, outlining how to navigate these key findings to best mobilize positive change for farmed animals in China.
Personalized Prediction of Negative Affect in Individuals with Serious Mental Illness Followed using Long-term Multimodal Mobile Phenotyping
Authors: Webb Christian A. , Ren Boyu , Rahimi-Eichi Habiballah , Gillis Bryce W. , Chung Yoonho , Baker Justin T.
Published: July 2024

Objective: Heightened negative affect is a core feature of serious mental illness. Over 90% of American adults own a smartphone, equipped with an array of sensors which can continuously and unobtrusively measure behaviors (e.g., activity levels, location, and phone usage patterns) which may predict increases in negative affect in real-time in individuals' daily lives.Method: Sixty-eight adults with a primary mood or psychotic disorder completed daily emotion surveys for over a year, on average (mean 465 days; total surveys = 12,959). At the same time, semi-continuous collection of smartphone accelerometer, GPS location, and screen usage data, along with accelerometer tracking from a wrist-worn wearable device, was conducted for the duration of the study. A range of statistical approaches, including a novel personalized ensemble machine learning algorithm, were compared in their ability to predict states of heightened negative affect.Results: A personalized ensemble machine learning algorithm outperformed other statistical approaches, achieving an area under the receiver operating characteristic curve (AUC) of 0.72 (for irritability) - 0.79 (for loneliness) in predicting different negative emotions. Smartphone location (GPS) variables were the most predictive features overall. Critically, there was substantial heterogeneity between individuals in the association between smartphone features and negative emotional states, which highlights the need for a personalized modeling approach.Conclusions: Findings support the use of smartphones coupled with machine learning to detect states of heightened negative emotions. The ability to predict these states in real-time could inform the development and timely delivery of emotionally beneficial smartphone-delivered interventions which could be automatically triggered via a predictive algorithm.
Are quantum medicine proponents also more likely to practice yoga: Robustness of an empirical taxonomy of traditional, complementary and alternative medicine practices
Authors: Purić Danka , Knezevic Goran , Teovanovic Predrag , Živanović Marko , Lazarevic Ljiljana B. , Puhalo Srđan , Zezelj Iris
Published: July 2024

Background: Traditional, complementary and alternative medicine (TCAM) encompasses a wide range of healthcare practices that are typically not part of “conventional” medicine and that are widely used in general populations. The aim of the study was to test for the most appropriate latent structure of a comprehensive instrument measuring TCAM use and to test its robustness in community samples. Methods: Sample for Study 1 consisted of n = 583 respondents from Serbia, and for Study 2 data were collected on n = 1152 participants in three countries (Serbia, Bosnia, and UK). In both studies, TCAM use was assessed via the TCAM-22 instrument.Results: In Study 1, using confirmatory factor analysis (CFA) we identified a hierarchical structure with a second-order factor subsuming four first-order factors (Alternative medical systems, New Age medicine, Natural product-based medicine, and Rituals/customs). We replicated the hierarchical four-factor structure in Study 2 using a multi-group CFA approach (MGCFA), where we found metric invariance of the structure across three countries. Conclusions: The obtained measurement invariance suggests that TCAM practices convey similar psychological meaning across countries/cultures and have similar patterns of use. Thus, the proposed instrument can serve as a valid tool to assess TCAM use in cross-cultural research.
Nova Abordagem Avaliativa: gamificação no processo educacional
Authors: Ferreira Thiago Maciel
Published: July 2024

Resumo: A gamificação no processo educacional não é apenas jogar para aprender, mas aprender, enquanto joga, transformando o desafio da educação em uma jornada empolgante de descobertas. O estudo se concentra em explorar, como, a gamificação pode ser efetivamente integrada, no ambiente educacional, para superar a falta de motivação e envolvimento dos alunos, desafiando o modelo convencional de ensino e aprendizagem. Este estudo visa explorar a implementação da gamificação no contexto educacional, com o objetivo de, potencializar, a motivação e o engajamento dos alunos. A mesma pesquisa, também adotou em seus caminhos metodológicos, a combinação da: Pesquisa-Ação, análise bibliográfica e pesquisa documental; bem como, aplicou-se a natureza não experimental, priorizando técnicas observacionais e descritivas. Esta, do mesmo modo, inclui, ainda, análises comparativas e sistemáticas robustas, para identificar tendências e inter-relações no campo da gamificação educacional, objetivando aplicações práticas e significativas. As avaliações gamificadas, contribuíram para uma aprendizagem mais ativa, com um foco em avaliações não punitivas e, um ambiente de aprendizagem motivador. A presente pesquisa, evidenciou que, houve um aumento na satisfação dos discentes, neste processo educacional, com 35% de alunos, extremamente satisfeitos. Bem como, apresentou: 42% de concordância na aplicação da gamificação, no processo avaliativo, no ensino superior. Assim, a gamificação foi considerada importante, pela maioria significativa dos estudantes, evidenciando seu papel positivo na educação. A pesquisa concluiu que, a aplicação da metodologia ativa: gamificação, é mais eficaz, do que, os métodos tradicionais de ensino. Este resultado positivo, foi evidenciado tanto pela observação direta, quanto pelas respostas dos alunos no questionário aplicado, destacando o sucesso em engajar os alunos e enriquecer o processo educacional.
Assessment of Operational Performance of Unsignalized Intersection using Microsimulation: A Case Study of Intersection at Pepsicola, Kathmandu
Authors: Budhathoki Sanjeev , Shrestha Pradeep Kumar
Published: July 2024

The intersection at Pepsicola, Kathmandu is a three legged unsignalized intersection. Three approach roads from Jadibuti, Kadaghari and Sanothimi merge at Pepsicola, Kathmandu to form the intersection. The study aims to assess the existing operational scenario of the intersection. The data collected is used to replicate the actual condition of the intersection in PTV VISSIM 2023 after sufficient calibration and validation. VISSIM was preferred over other simulation softwares due to its easiness in use and flexibility. The performance of the intersection is evaluated in terms of Level of Service and Queue length. During the peak hour i.e. 9:00 AM to 10:00 AM the intersection accommodates 3759 vehicular traffic and during the same hour the intersection serves 318 pedestrians. At present condition the Level of Service of the intersection is C with average total delay of 18.62 Sec.
A Study on Job Satisfaction among Engineers with Master’s Degree in Construction Management in Kathmandu Valley
Authors: Shrestha Manjila , Bhattarai Subash Kumar
Published: July 2024

This study comprises of the assessment of level of job satisfaction of the engineers who hold a master’s degree in construction management in Kathmandu Valley by means of the Minnesota Satisfaction Questionnaire. The study population includes three engineering colleges in Kathmandu Valley. They are Nepal Engineering College (NEC), Institute of Engineering (IOE), Lumbini International Academy of Science and Technology (LIAST). 70 sample responses were received as primary data. Cronbach’s alpha was calculated by using SPSS and found to be 0.939. Engineers with master’s degree in construction management are highly satisfied with their job due to relation with co-workers with mean value of 3.94. This suggests that their colleagues' supportive behavior positively influences their work progress. In contrast, engineers are highly dissatisfied with the ‘Remuneration - My pay scale vs Job description’ as their value is below the acceptable level i.e. 2.74.
The Performance of CIP Scheme in Solving Advection Equation
Authors: Fei Tan Jeff , Tion Puay How
Published: July 2024

Constrained interpolation profile (CIP) approach is reviewed in this paper. This research provides a performance comparison between CIP and upwind scheme, a different general method for solving advection equations. The performance of numerical method will be judged based on its accuracy in solving advection equation. The simulation results indicate that CIP scheme advection is more accurate than Upwind scheme advection due to its minor numerical deviation from exact solution.
Entrepreneurial Deliberateness of Youth of Karnali Province
Authors: K.C. Govinda
Published: July 2024

Any nation's overall development is based on careful consideration and in-depth development of each subsector of the local, regional, and national economies. An economy's ability to grow and develop is greatly influenced by entrepreneurship. This study employs the theory of planned behavior (TPB) as a framework. The variables of PA (Personal Attitude), PBC (Perceived Behavioral Control) and SN (Subjective Norms) are heavily weighted in this study. The study's foundation is a quantitative research paradigm. Utilizing a structured questionnaire, data were gathered. The youth of the Karnali Province who are presently enrolled in Birendranagar Surkhet to pursue higher education make up the study's population. Regarding this research, the convenience sampling method was employed. The study's practical implications center on a trend that policymakers should watch going forward: teach young people in the Karnali province the skills they need to get information from the market about starting a business, expand their access to financing, and improve the viability of their business ideas.
Evaluation of groundnut shell for enhancing geotechnical performance of weak soil
Authors: Basnet Jhalak Man , Baidya Purnima , Dahal Bhim Kumar
Published: July 2024

This research delves into the persistent challenge of strengthening weak soil for infrastructural development, exploring the potential use of agro waste such as groundnut shell ash (GSA) as a soil improvement admixture. Through a comprehensive study on various geotechnical properties of soil, different proportions of GSA, both solely and as alkaline-activated were used. The investigation evaluated Atterberg’s limits, compaction characteristics, and unconfined compressive strength. Comparative analyses revealed the efficacy of these admixtures. Results indicated that alkaline-activated GSA demonstrated superiority across all geotechnical properties, notably transforming high-plastic soil into low-plastic soil, unlike GSA-only treatments, which altered specific properties but failed to induce the desired transformation. Both additives reduced the maximum dry unit weight but increased the optimum moisture content. The alkaline-activated GSA demonstrated a lesser decrease in unit weight. Moreover, this form of GSA enhanced the compressive strength of natural soil by 11.71 times at 10% GSA content, compared to the 2.2-fold increase achieved by soil treated only with GSA content of 6%. Therefore, the results indicated the use of GSA as viable agro waste for sustainable soil stabilization of soil deposits in Kathmandu Valley.
Energy performance of rammed earth building: A Kathmandu valley case study
Authors: Uprety Priyanka , Shrestha Barsha , Uprety Sanjaya
Published: July 2024

As the world's energy demands soar, the building sector is under pressure to innovate. Rammed earth (RE) construction emerges as a sustainable and efficient alternative that could revolutionize building design. With the right materials, preparation methods, and a focus on energy use efficiency, RE can significantly reduce our reliance on conventional heating and cooling systems by leveraging the natural thermal mass of the walls to maintain a consistent internal temperature year-round. Despite growing interest, particularly in the Kathmandu valley, there is a lack of research on the actual energy performance of RE buildings. This study aims to evaluate the energy performance of RE buildings using thermal imaging and energy simulation to compare RE walls with traditional brick walls. Results indicate that RE buildings perform better, with temperature differences of 2.9°C and 2.1°C in the south and west walls, respectively, as measured by a thermal imager at a distance of 1 meter and a height of 1.5 meters. Furthermore, simulation results reveal that RE construction exhibits the lowest heating and cooling loads, while brick masonry construction shows the highest. These findings suggest that incorporating RE construction can lead to significant energy savings and enhanced thermal comfort in buildings, offering practical applications for sustainable building practices and broader generalizability in similar geographical and climatic contexts.
Concrete compressive strength prediction by artificial neural network approach
Authors: Thapa Jyoti
Published: July 2024

The structural integrity of concrete structure is explicitly influenced by concrete compressive strength (CS). Timely prediction of concrete compressive strength exhibits a good performance in the field of construction. However, it is very challenging due to the unpredictable physical and mechanical properties of concrete and its constituent ingredients. To mitigate the limitation of the laboratory testing-based experimental method, this manuscript presents optimal artificial neural network (ANN) model to forecast CS. For this purpose, total number of 776 datasets were collected from previous research papers. The preprocess dataset was randomly split into training and tesing set. After that,  optimal artificial neural network (ANN) model was developed by establishing appropriate hyperparameters. The overfitting and validation loss were stabilized by loss function assessment with Adaptive Optimization Algorithms (Adam) optimizer. The ANN output results exhibit good prediction performance with R-squared value of 0.87, and errors such as MAE, MSE, and RMSE with values of 3.419 MPa, 21.909 MPA, and 4.68 MPa, respectively. In addition, SHAP value of the output model shows volume of cement and water has highest positive impact, whereas water and fly have highest negative impact on concrete compressive strength. This manuscript shows the power of machine learning techniques to timely and efficient prediction of concrete compressive strength. Thus, this optimal ANN model is applicable in concrete made infrastructure design and construction industry.
Experimental designs and spatial and/or temporal models in agricultural, livestock and forestry production systems
Authors: Borges Mira Alejandra , Terra José , Dixon Philip
Published: July 2024

One of the main objectives of agronomic experimentation is to obtain reliable data to establish comparisons between treatments and test working hypotheses. To meet this objective, it is essential to have well-designed and planned experiments, as well as a data analysis strategy that takes into account the design factors and additional relevant information, mainly in large field scale trials evaluated for several years which generate correlations in space and/or time. The purpose of this research was to evaluate the efficiency of experimental designs with different degrees of complexity and the adjustment of spatial, temporal and spatio-temporal models in experiments with different crops, seeking to avoid biases in the variance estimates, and an adequate control of the empirical type 1 error rate. The most relevant results of this work show that with high experimental field heterogeneity and large experiment size, the choice of the experimental design becomes essential to obtain accurate and precise treatment effect estimates. Once the appropriate experimental design has been chosen, spatial modeling of the correlation between experimental units further improves the design performance. These improvements can be accompanied by unbiased standard errors and a correct control of the type 1 empirical error rate if the model used to estimate the spatial correlation of the response variable is adequate. Additionally, with high number of replicates, reliable results can be obtained beyond the preferred spatial model. On the other hand, when intra-plot spatial correlations are included, the advantage of spatial modeling is not as clear. In the case of forest tillage experiments, the inclusion of spatial correlation between trees in the same plot increased the precision of comparisons between treatment means, achieving reductions in the standard error of the mean difference of up to 40 %. However, in trials conducted on permanent grasslands with large plot sizes, the advantages were not clear. These differences between trials may be due to the scale at which these spatial correlations are manifested, the number of subsamples per plot and the effect of treatments on the spatial distribution of the variables of interest.
horse and its culture as a vector of development
Authors: Lena Lacuesta Ruben Eduardo , Morales Hermes , Marques Claudio , Rovere Gabriel
Published: July 2024

Uruguay, as an inhabited space, has developed a historical and sustained link with extensive ranching based on natural fields. The habitat presented very favorable conditions that stimulated the multiplication of the first cattle that the colonizers introduced to the country, at the dawn of the 17th century. This process, which is already more than four centuries old, allowed the consolidation of an agro-industrial chain around cattle, which, although it underwent very notable transformations over time, today is one of the most important economic items in the country. This activity occupies, in a relative way, the largest productive area of the national territory and its persistence is a very convincing proof of its sustainability. Its economic results, social consideration and respect for the environment have been qualities of a vector of support for society as a whole. Now, it is necessary to emphasize that this story would not have been possible without the presence of the horses. Their natural attributes as a species and their ductility transformed them into the most important instrument used by human beings to be able to handle the increasingly numerous herds that grew in the fields. Over time, and with the appearance, development and consolidation of equestrian sports, horses -without losing their importance in work and in rural life in general and functional to extensive livestock farming which, from a numerical point of view, continues being their main destination- they gradually became outstanding protagonists. All these temporal and spatial considerations related to the horse and managers of a very expressive present are those that would be justifying an innovative and profound reflection on the set of equestrian activities and their potential to become a vector capable of contributing to the sustainable development of the department and the region.
Perancangan Sistem Informasi Peminjaman Sarana dan Prasarana Universitas Dhyana Pura Berbasis Web
Authors: Bernadus I Nyoman , Gunawan Putu Wida
Published: July 2024

Proses permohonan peminjaman sarana dan prasarana di lingkungan Universitas Dhyana Pura masih menggunakan cara konvensional yakni pemohon wajib datang di bagian Kemahasiswaan membawa surat permohonan peminjaman untuk diteruskan pada Wakil Rektor II sebelum disposisi di Kepala Bagian Sarana dan Prasarana. Pemohon menunggu dalam rentang waktu 1 hari untuk mengambil surat tanggapan di Kepala Bagian Sarana dan Prasarana, namun pemohon dapat mengalami kesulitan dalam proses peminjaman dikarenakan jadwal yang hanya terdapat di ruang Kepala Bagian Sarana dan Prasarana. Sistem Informasi Peminjaman Sarana dan Prasarana dirancang untuk meningkatkan efisiensi dan transparansi dalam proses peminjaman fasilitas kampus. Tujuan sistem informasi ini guna memperbaiki sistem konvensional sehingga dapat memudahkan dalam mengajukan permohonan peminjaman, menerima informasi, pengembalian, dan juga dapat memudahkan bagian pengelola dalam proses memantau ketersediaan dan laporan aktivitas peminjaman dan pengembalian sarana dan prasarana. Dalam perancangan sistem menggunakan metode System Development Life Cycle (SDLC). Hasil dari rancangan sistem dapat digunakan untuk Prototyping dalam pengembangan pembuatan perangkat lunak sistem infomasi peminjaman sarana dan prasarana yang lebih baik dan efisien.
Kata Kunci : Sistem Informasi, Peminjaman Sarana dan Prasarana, Perancangan Sistem
Analisis Data Akurasi Kontrasepsi Hormonal dan Non-Hormonal Menggunakan Algoritma C4.5
Authors: Narendra Sebastianus Aditya , Setiawan Pradita Aldi , Khasanah Uswatun Destri , Trengganis Afiftah
Published: July 2024

Penelitian ini mengkaji Program Keluarga Berencana (KB) di Indonesia dengan fokus pada pemilihan metode kontrasepsi oleh pasangan suami istri. Pada tahun 2020, terjadi penurunan penggunaan berbagai metode kontrasepsi sebesar 10% akibat kekhawatiran terkait pandemi COVID-19. Dampaknya adalah peningkatan 15% dalam kehamilan tidak diinginkan pada tahun 2021. Metode kontrasepsi hormonal menjadi pilihan umum di Indonesia, di mana pemerintah telah mengimplementasikan program untuk mengontrol pertumbuhan penduduk. Algoritma C4.5 melalui perangkat lunak RapidMiner diusulkan sebagai metode sederhana untuk pemilihan metode kontrasepsi, baik hormonal maupun non-hormonal, berdasarkan jumlah anak. Tinjauan pustaka menjelaskan konsep dasar sistem, sistem pakar, dan berbagai metode kontrasepsi. Penelitian terkait mencakup hubungan pengetahuan ibu dengan pemilihan kontrasepsi, tingkat pengetahuan pasangan usia subur, dan hubungan antara tingkat pengetahuan ibu dengan pemakaian kontrasepsi hormonal dan non-hormonal. Metode penelitian menggunakan pendekatan deskriptif kuantitatif, dengan analisis data yang melibatkan teknik deskriptif kuantitatif menggunakan RapidMiner dan algoritma C4.5. Data bersumber dari berbagai sumber, termasuk situs resmi https://www.kaggle.com/. Hasil dan pembahasan menyajikan data akurasi penggunaan kontrasepsi, dengan kontrasepsi non-hormonal lebih dominan digunakan. Kesimpulan menyoroti pentingnya kontrasepsi dalam mengendalikan kelahiran, dengan kontrasepsi hormonal lebih populer di kalangan wanita usia muda, sementara kontrasepsi non-hormonal lebih umum di antara wanita usia lanjut. Penelitian ini menyediakan pemahaman yang mendalam tentang pemilihan kontrasepsi di Indonesia, dengan rekomendasi penggunaan algoritma C4.5 sebagai pendekatan sederhana untuk membantu pasangan suami istri dalam memilih metode kontrasepsi yang sesuai dengan kebutuhan dan situasi keluarga mereka.
Kulit Ikan Tuna Yellowfin (Thunnus albacares) untuk Produksi Gelatin dengan Variasi Larutan NaOH dan Waktu
Authors: Mafazah Eli Mudrik
Published: July 2024

ABSTRAK
Kulit ikan tuna Yellowfin (Thunnus albacares) mengandung kolagen dimana sering dimanfaatkan untuk membuat gelatin halal dari produk samping industri filet ikan. Penelitian ini dilakukan dalam rangka mengidentifikasi rendemen, kekuatan gel,  viskositas, berat molekul gelatin kulit ikan tuna Yellowfin. Telah dilakukan dengan cara perendaman kulit ikan tuna Yellowfin larutan NaOH 0,01; 0,03; 0,05 M dimana formulasi kulit ikan : larutan NaOH 1:6 (b/v) pada suhu ruang durasi 12; 18; dan 24 jam. Hasil ekstraksi paling bagus diperoleh pada konsentrasi larutan NaOH 0,01 M dan waktu perendaman 12 jam yang mempunyai rendemen 12,49 %db; kekuatan gel 291,73 g Bloom; viskositas 8,6 cPs dan titik leleh 35 °C. Kisaran berat molekul adalah 100 kDa untuk rantai α. Kekuatan gel dan titik leleh gelatin bovine yaitu 309,7401 g Bloom dan 36,33 °C, sedangkan viskositas gelatin bovine 5,6 cPs. Pola SDS-PAGE dari gelatin kulit ikan tuna Yellowfin sesuai dengan gelatin bovine yang menghasilkan dua pita pada daerah berat molekul 100 kDa.
 
kata kunci : ekstraksi, gelatin, NaOH, yellowfin
Does Gender Matter in Colorectal Cancer?
Authors: Chandio Ashfaq
Published: July 2024

Introduction: Colorectal cancer is one of the most common and lethal cancer worldwide, and it exhibits differences in incidence, pathogenesis, molecular pathways, and outcome depending on the location of the tumour. Colorectal cancer is a disease strongly influenced by gender, mortality rates in males considerably higher than females Aim: To determine the gender disparities in the incidence of Colorectal cancer Methods: All patients managed with colorectal cancer from January 2015 through December 2019 were retrospectively identified from the referral database created by the colorectal specialist nurses in the colorectal service. Inclusion: All patients diagnosed with colorectal cancer. Exclusion: Tumour in the Appendix, Anal canal, small bowel, metastatic tumours of unknown primary Results: 976 patients were diagnosed with bowel cancer percentages of studied participant were Male 52.60% and Female 47.40%. The mean age of 74.14 years. Sixty six (66) 6.76% patients were excluded from the study. The location of colon cancer is also changing. The incidence rate of Right side colon cancer in women was much higher than that in men 1.20:1, and on Left side colon cancer including rectum was much higher in men than that in women this was especially exhibited in cases of rectal cancer, for which the male to female ratio was increased to 1.54:1 whereas the male to female ratio of left colon cancer 1.26:1 The incidence rates were increasing in all groups over time, especially in the 50 -79 years group. Incidence of colorectal cancer was greater for cancers of the left side of colon than right colon (62.41% vs 37.58%). Conclusion: There are not significant sex differences in access to and effectiveness of Colorectal cancer treatment. Screening provides effective opportunity to prevent Colorectal cancer. Gender-specific guidelines for screening, treatment, and prevention protocols for colorectal cancer can be established to decrease the mortality and increase the quality of life.
Wilson's Disease
Authors: Haider Rehan
Published: July 2024

In 1912, Kinnear Wilson was the first to describe an inherited fatal disease associated with progressive lenticular degeneration, chronic liver disease and cirrhosis (Wilson 1912) [1]. In the same year, Kayser and Fleischer found that patients with Wilson's disease (WD) often had brownish deposits of copper on the cornea, now called Kayser-Fleischer rings (Fleischer 1912) [2]. WD is an autosomal recessive metabolic disorder. Its ATP7B gene encodes a copper-transporting ATPase (Bull 1993, Tanzi 1993, Petrukhin 1993, Yamaguchi 1993) [3,4,5,6]. A genetic defect in the ATP7B protein reduces Biliary excretion of copper leads to accumulation of copper in the cornea and various organs, including the liver, brain, and kidneys. Alteration of the ATP7B protein also reduces copper incorporation into ceruloplasmin. The corresponding presence of ceruloplasmin APO (ceruloplasmin without copper incorporation) results in decreased circulating levels of ceruloplasmin due to the shortened half-life of the APO protein. Thus, despite the accumulation of copper in many organs, circulating levels of copper and ceruloplasmin are reduced in most patients with WD. The prevalence of WD is rare, estimated at 3 per 100,000 in the general population (Friedman 1990) [7]. The clinical picture may vary. Some patients with WD are diagnosed with liver problems, while others have neurological or psychiatric symptoms; many patients show both liver and neurologic disease (Figure 1). Episodes of hemolysis and renal abnormalities may also occur. WD typically affects children and younger. Adults and is rarely seen in adults over 40 years of age. WD is fatal if not treated appropriately. Medications to treat WD are copper chelators. such as penicillamine and trientine (Walshe 1956) [8]. Lately, zinc has been. it is used to reduce the intestinal absorption of copper and to detoxify free circulating copper. Patients with fulminant liver failure or decompensated cirrhosis. may need a liver transplant (LTX) to cure WD.
Pemberdayaan Lansia Melalui Program Pendidikan Sepanjang Hayat
Authors: Hutahaean Erik Saut Hatoguan , Nugraha Susiana , Fitriani Yulia , Merida Sarita Candra , Febrieta Ditta
Published: July 2024

Menua merupakan proses natural dalam siklus usia manusia. Sejalan dengan usia yang bertambah lebih banyak orang-orang dengan usia lanjut mengalami penurunan pada kondisi fisiknya, psikologis, dan kehidupan sosialnya. Keadaan hidup sejahtera (well-being) adalah suatu perolehan manusia secara universal, termasuk individu lanjut usia. Program sekolah lansia dari Indonesia Ramah Lansia merupakan langkah yang realistis untuk memenuhi hak mendapatkan kesejahteraan yang adaptif dan solutif untuk membantu yang terkait dengan penurunan kondisi pada lansia. Sebagi langkah pertama, program dimulai dengan launching sekolah lansia untuk komunitas lansia di Bekasi Utara. Kurikulum pembelajarannya membantu tetap mandiri, aktif, dan bahagia di usia yang sudah lanjut. Pertemuan pertama memberikan efek kepada penguatan identitas positif pada peserta, dan menumbuhkan keyakinan masih memiliki kemampuan. Berpastisipai dalam sekolah lansia mendapatkan kesempatan belajar tentang pengetahuan keterampilan hidup meskipun berada pada fase usia lanjut.
Psikoedukasi Perilaku Hidup Bersih dan Sehat Pada Anak-Anak SPS Bunga Tanjung
Authors: Bangun Mic Finanto Ario , Japalsyah Rafika , Rahmawat Annisa Dhani , Andini Rere Putri , Tasya Faidah Ana , Saputra Bagas , Suroyah  , Oktavia Nadya Krissan , Prihastiwi Anisa Rahmania
Published: July 2024

Tujuan dari program Kuliah Kerja Nyata Tematik (KKNT) ini adalah untuk memberikan edukasi mengenai Perilaku Hidup Bersih dan Sehat (PHBS) pada anak serta warga sekolah di SPS Bunga Tanjung. Periode perkembangan yang dimiliki anak usia dini / usia sekolah akan membentuk kepribadian dasar, sehingga pembiasaan Perilaku Hidup Bersih dan Sehat (PHBS) sangat diperlukan. Dapat disimpulkan bahwa program kegiatan penyuluhan yang dilakukan kepada anakanak di SPS Bunga Tanjung RW013, Duren Jaya, Kota Bekasi mengenai Perilaku Hidup Bersih dan Sehat (PHBS) berjalan dengan baik, sesuai dengan apa yang telah direncanakan. Pelaksanaan kegiatan program berlangsung pada bulan Desember  2022 Adapun saran yang dapat kami berikan selama pelaksanaan KKNT ini adalah dapat membangun raport dan menyesuaikan diri dengan anak-anak.
Menumbuhkan Rasa Percaya Diri Pada Anak Saat Pandemi Covid 19
Authors: Merida Sarita Chandra , Mulya Fikri Habi
Published: July 2024

Semenjak pandemi, anak-anak lebih banyak menghabiskan waktu di rumah karena sebagian besar kegiatan dilakukan secara daring. Dampaknya mereka jarang bersosialisasi sehingga kurang percaya diri saat berinteraksi bersama dengan orang lain. Kegiatan ini bertujuan untuk memberikan psikoedukasi tentang rasa percaya diri pada anak untuk membangun rasa kepercayaan diri serta keberanian pada anak. Metode yang digunakan dalam kegiatan ini menggunakan psikoedukasi dengan memberikan ceramah tentang sikap percaya diri. Selain itu menggunakan roleplay melalui aktivitas bermain untuk menumbuhkan sikap percaya diri anak melalui bermain, menumbuhkan kebersamaan, kerjasama, serta perasaan memahami satu sama lain. Kegiatan ini dilakukan di Desa Sukajadi, Kecamatan Sukakarya, Jawa Barat. Diikuti oleh anak usia 7-12 tahun yang terdiri dari 8 anak laki-laki dan 2 anak perempuan. Hasil yang diperoleh adalah semua anak yang terlibat dalam kegiatan ini mendapatkan pemahaman baru tentang kepercayaan diri. Hal itu terlihat dari perubahan perilaku yang tampak yaitu mereka menjadi sangat antusias dengan kegiatan yang dilaksanakan dan anak menjadi lebih akrab dengan temannya, berani berbicara serta bercerita. Selain itu dengan pengetahuan baru tentang kepercayaan diri, mereka lebih percaya diri dan memiliki cita-cita yang ingin dicapai. Sebelumnya mereka bingung saat ditanya harapan yang ingin dicapai, merasa malu, namun setelah mengikuti penyuluhan mereka menjadi lebih berani menentukan cita-citanya.
ENHANCED MODEL OF THE SYSTEM FOR PROVIDING COSMETOLOGY SERVICES TO THE POPULATION
Authors: Kotyk Nellia O. , Yashchenko Yurii B.
Published: July 2024

Introduction. The relevance of the necessity to review approaches to the organization of the existing system for providing cosmetology services to the population is driven by the rapid increase in cosmetology service providers and the high demand for these services. This occurs under conditions of an imperfect regulatory framework governing the provision of aesthetic, cosmetic, and cosmetology services and their list, the absence of standards for their delivery, the treatment of complications, and the training of qualified medical personnel.
Aim. To develop an enhanced model for organizing the provision of aesthetic, cosmetic, and cosmetology medical services to the population.
Materials and methods. The study was conducted through a systematic approach and analysis using the bibliosemantic method and content analysis.
Results. The development of the conceptual model for providing cosmetology services to the population is based on the findings of domestic scientists, which include a comparative legal analysis of the cosmetology service market in Ukraine and other countries worldwide. In developing the model, a differentiation of medical services in the cosmetology market into aesthetic, cosmetic, and cosmetology medical services was carried out by identifying their distinct characteristics. Due to the absence of a clear list of cosmetology services in the healthcare sector, we relied on the National Classifier of Types of Economic Activity and the State Classifier of Products and Services for classification. In determining providers of cosmetology services and their functions, we referred to the directory of qualification characteristics of healthcare professionals. The system's conceptual model for providing cosmetology services to the population is positioned as a cluster model, which encompasses organizational and methodological aspects and is based on the triad of medical science, practice, and education.
Conclusions. A conceptual model for the system of providing cosmetology services to the population has been developed based on the classification of types of medical activities of service providers using the principles of systemic and socio-engineering approaches. The expected outcomes of its implementation should include: improvement in the quality of cosmetology services provided to the population, provision of highly qualified medical personnel, development of interdisciplinary communications, economic efficiency, and ensuring infectious, surgical, and pharmaceutical safety for consumers of aesthetic, cosmetic, and cosmetology medical services.
THE ROLE OF PHARMACOGENOMIC STUDIES IN INCREASING THE EFFECTIVENESS AND SAFETY OF CLINICAL APPLICATION OF STATINS
Authors: Skavinska Oleksandra О. , Rossokha Zoia I. , Podolska Svitlana V. , Ievseienkova Olena G. , Buriak Oleksandr A. , Olkhovych Volodymyr P. , Gorovenko Natalia G.
Published: July 2024

Introduction. Currently, hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) are among the most widely used hypolipidemic drugs worldwide. However, to date, the problems of the insufficient effectiveness of statin therapy and the development of unwanted side effects in patients remain not fully resolved. The identification of key variants in genes whose protein products are involved in statin metabolism and their effect on carriers during therapy may improve the efficacy of statin treatment and help prevent unwanted side effects, and therefore may be a valuable tool for clinicians when monitoring the progress of patients. to whom these medicines were prescribed.
Aim. To summarize the information available in the literature on variants in genes that affect the effectiveness and safety of statins during treatment.
Materials and methods. An assessment of the current literature on the role of genetic variants in the effectiveness and safety of statins was made. The search was performed in Scopus, Web of Science, Google Scholar, and PubMed databases.
Results. The chemical structure and metabolism of statins are described. A review of the current literature on the impact of variants in ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1 genes on the effectiveness of statin therapy and the development of unwanted side effects in patients is presented. These genes have been shown to be associated with the pharmacodynamics and pharmacokinetics of statins, which affect their efficacy and safe use.
Conclusions. Since recent studies have demonstrated the influence of protein transporters such as ABCB1, ABCG2, OATP and BCRP, as well as the cytochrome P450 system, on the pharmacokinetics and pharmacodynamics of statins, further large-scale studies focusing on drug transporters are needed. The review focused on finding correlations between polymorphic variants in the genes encoding the aforementioned transporters and CYP enzymes and the efficacy and safety of statins. The presented data of the literature emphasize the importance of pharmacogenetic studies of statins, which can be useful to clinicians to minimize the negative consequences of taking these drugs and improve the effectiveness of treatment of patients who are carriers of risk alleles.
Contradispositivo tojolabal: hacia una reivindicación de la alteridad en tanto resistencia
Authors: Martínez García Hugo ,   Universidad de Guanajuato
Published: July 2024

This paper analyzes the place alterity takes in the tojolabal subjectivation process. It is about the exegesis we can deliver from it and its possibilities as resistance against neoliberal power structures. Such resistance is realized through the constitution of a community-subject who understands herself/himself as a harmonic part of the world she/he belongs to. In order to do so, the concept of dispositif is used to illustrate the way neoliberal power structures constitutes subjects who conceive themselves as isolated and related to their environment through a maximizing rationality. The concept of dispositif is turned into “counter-dispositif” to understand the tojolabal practices as a means of opposition to the neoliberal scheme. It will be shown how thenetwork of tojolabal counter-dispositifs constitutes the possibility of creating a community subject that works as a way of resistance, due to his/her connection to otherness.
Noah in the Animal Apocalypse (1 En. 89:1-9)
Authors: Drawnel Henryk
Published: July 2024

The Aramaic description of the flood in 1 En. 89:1–9 has survived in two fragments from Qumran (4Q206 frg. 8 I and frg. 9), which contain a shorter text than the Ethiopic translation. This article is an analysis of the presentation of the figure of Noah in the longer version of the Ethiopic Animal Apocalypse in the context of the Ethiopic Book of Enoch and in relation to Mesopotamian traditions associated with the flood. After being told the secret about the flood by a “man” (an angel), Noah, the white bull, works as a carpenter and builds a huge boat. After the flood, transformed into a “man” (a supernatural figure in the symbolism of the Animal Apocalypse), he leaves his three sons. This description of Noah brings him closer to the main characters of the flood in Mesopotamian sources.
New approaches in the tomographic visualization of joints using X-ray contrast nanoparticles and laser radiation
Authors: Omelchenko A. I. , Dyachkova I. G. , Zolotov D. A. , Kaloyan A. A. , Shepeleva V. O. , Podurets K. M.
Published: July 2024

New approaches in X-ray visualization of joints using various radiation sources are considered. Investigations of the structure of joint cartilage tissue and model objects structurally and functionally similar to cartilage tissue were conducted using X-ray radiation from a laboratory microtomograph and synchrotron radiation. Images of the internal structure of model objects and cartilage tissue impregnated with X-ray contrast agent were obtained using projection radiography and microtomography methods. Colloidal solutions of biocompatible nanoparticles of titanium and molybdenum oxides were used as contrasting agents. The nanoparticle concentration distribution through tissue depth was measured by image processing.
Localization of aluminum in ZnO: Al layers during magnetron sputtering deposition
Authors: Asvarov A. Sh. , Muslimov A. E. , Kanevsky V. M. , Akhmedov A. K. , Abduev A. Kh. , Kalazhokov Z. Kh.
Published: July 2024

The features of aluminum localization and the mechanism of donor center formation in ZnO:Al layers synthesized by high-frequency magnetron sputtering are studied. It is shown that aluminum predominantly localizes at grain boundaries of zinc oxide in its own oxide phase. The mechanism of aluminum oxidation at grain boundaries significantly depends on the oxygen content in the working chamber: during sputtering in an atmosphere of pure argon under conditions of oxygen deficiency, aluminum oxidation occurs as a result of interaction with oxygen from the surface layer of zinc oxide crystallites, forming surface donor centers at grain boundaries. With an increase in the partial pressure of oxygen, aluminum is predominantly oxidized by oxygen from the gas atmosphere, forming its own barrier phase at grain boundaries.
Laboratory X-ray microphotography: a method of inner three-dimensional structure reconstruction of different nature objects
Authors: Zolotov D. A. , Buzmakov A. V. , Dyachkova I. G. , Krivonosov Yu. S. , Dudchik Yu. I. , Asadchikov V. E.
Published: July 2024

A brief retrospective of the development of laboratory X-ray microtomography at the A. V. Shubnikov Institute of Crystallography of the Russian Academy of Sciences (IC RAS) is presented. The main methods and approaches that have increased the informativeness of microtomographic measurements are outlined, such as the use of monochromatic radiation, the application of phase-contrast method, and the method of diffraction tomography (topo-tomography). The designs of the instruments created and operating at IC RAS are described, and some experimental results obtained with them are presented.
Теплоемкость Na2W2O7 в интервале 1.9–220 K
Authors: Мусихин А. Е. , Миллер Е. Ф. , Гельфонд Н. В.
Published: July 2024

Представлены результаты исследования монокристалла дивольфрамата натрия на основе полученных экспериментально данных о теплоемкости. Теплоемкость Na2W2O7 измерена методом релаксационной калориметрии в интервале 1.9–220 K. Аномалий в теплоемкости, связанных с фазовыми переходами, не обнаружено. Выполнена экстраполяция теплоемкости к 0 K, и определена температура Дебая при нуле. На основе экспериментальной теплоемкости рассчитаны термодинамические функции: энтропия, приращение энтальпии и приведенная энергия Гиббса.
Параметры модели UNIQUAC для описания фазового равновесия пар – жидкость изотопных смесей водорода H2–D2, H2–HD, HD–D2
Authors: Короткова Т. Г.
Published: July 2024

Выполнен анализ расчетных и литературных экспериментальных данных по коэффициентам активности изотопов водорода в смесях H2–D2, H2–HD. Расчетные данные получены на основе известной теории многокомпонентных жидких растворов водорода (Шервуда), учитывающей неидеальность парожидкостного равновесия. Максимальное относительное отклонение составило 5.4 %. Проверена адекватность описания упругости паров чистых компонентов H2, D2, HD эмпирическими уравнениями, и выбраны уравнения для расчета фазового равновесия в системе пар — жидкость. На основе математической обработки литературных экспериментальных данных по фазовому равновесию изотопных смесей водорода H2–D2, H2–HD, HD–D2 найдены параметры бинарного энергетического взаимодействия модели UNIQUAC для расчета коэффициентов активности компонентов H2, D2, HD. Вычислены коэффициенты разделения смесей H2–D2, H2–HD, HD–D2 при различных температурах кипения в зависимости от давления и состава. На основе полученных результатов построены диаграммы фазового равновесия y-x и t-x,y при атмосферном давлении. Расчетные исследования коэффициента разделения данных изотопных смесей показали отличие качественного поведения зависимости кривой коэффициента разделения от состава легколетучего компонента, полученного по модели UNIQUAC, по теории Шервуда и при рассмотрении смеси в качестве идеальной. Кривая коэффициента разделения, вычисленная по модели UNIQUAC, является слегка выпуклой к оси абсцисс, по теории Шервуда — убывающей, а при рассмотрении идеальной смеси, подчиняющейся закону Рауля, — возрастающей и практически прямой линией со значительным углом наклона к оси абсцисс. Приведены графические расчетные зависимости температуры кипения смеси H2–D2 от концентрации H2 в жидкой фазе при различных давлениях. Исследован профиль распределения компонентов H2, D2, HD по высоте 21-й тарельчатой ректификационной колонны для модельной трехкомпонентной смеси H2–HD–D2 состава, в % мол.: xH2 = 0.014; xHD = 60; xD2 = 39.986 для процесса замкнутой ректификации с учетом и без учета коэффициентов активности компонентов. Выявлено расхождение в профилях для H2 и HD. Наличие параметров бинарного энергетического взаимодействия UNIQUAC между молекулами изотопов водорода позволит проводить численный анализ разделения изотопных смесей водорода низкотемпературной ректификацией в среде моделирования Hysys при различных режимах работы ректификационной колонны или каскада колонн с целью поиска оптимальных структурных схем разделения.