bluuebunny/crossref_metadata_2025 huggingface dataset:
The Patient Profile of a Uk Osteopathic Student Out-patient Clinic: a Retrospective Descriptive Study
Authors: MacMillan Andrew
Published: June 2020

Osteopathy is a healthcare discipline regulated by statute within the UK. Little is known regarding the day-to-day practice of osteopaths. The aim of this study was to investigate the patient profile within a teaching institution. Data regarding patients and their presenting symptoms are routinely collected at UK OEIs. The data were analysed from a sample spanning three years. The demographic data collected described the patient population sample in terms of age range, gender, occupation and ethnicity. The patient symptom data collected was comprised of site of pain, aetiology, symptom duration and symptom pattern. The study first profiles the clinic patient population, describing the prevalence of the types of presenting complaint, and then profiles the demographics of the sample. The study then compared the demographic data to the symptom data to assess for trends within the sample.Methods Data from a total of 3,760 patient records attending between 02/01/13 and 24/12/15 were analysed. This data was cleansed leaving 3243 complete patient records. The data was then analysed using descriptive and inferential statistics via the StatisticalPackage for Social Sciences. The statistical tests used were the nonparametric test, Kendall’s rank order correlation, and Pearson’s Chi-Square correlations for the ordinal data. Distributions and frequency counts were performed to describe the data using Microsoft excel.Results The sample of the clinic population analysed included 3243 patient records, of which 1834 were female (57%) and 1408 (43%) were male. The ethnic profile of included records was predominantly Caucasian at 68%, with 13% of Black Minority Ethnic origin and 12% South Asian. The age range is from 0 to 80+ years, and the majority of participants are aged 30-39 (31%). The most common sites of pain were: low back (33%), neck (23%), upper back (9%), mid back (7%), and shoulder (6%). The results suggest that gender may influence site of pain, and that ethnicity is not associated with symptom duration but may be associated with symptom site and pattern, however the association is weak and may not be generalizable beyond this cohort. No statistical significance was found between occupation and pain. Conclusion This study is a detailed profile of a UK OEIs clinic’s patient population. It investigated potential links between demographic data and presenting complaints. Further study with a larger sample size would allow more reliable analysis of data, repeating similar investigation at other institutions may enhance understanding of this topic and highlight if regional differences occur. This study highlights that there are no discernable correlation between pain presentation and occupation or ethnicity. IMPLICATIONS FOR PRACTICEThis study adds to the existing research literature by:Profiles the patient population of a UK OEI with reference to; ethnicity, age and gender.Demonstrates a relationship between gender and sites of pain and no link between occupation and presenting complaint.
Dietary exposure of deoxynivalenol affected cytochrome P450 and growth related-gene expression via DNA methylation in piglet liver
Authors: Liu Aimei , Hu Siyi , Zhu Xiaohui , Ihsan Awais , Wu Qinghua , Sun Lvhui , Wang Xu
Published: June 2020

Background

Deoxynivalenol (DON) is an inevitable contaminant in animal feed and human food and can lead to decreased appetite and growth retardation in children and piglets, which are often used as models for children. Hepatotoxicity induced by DON is closely related to growth inhibition. Although many molecular mechanisms are related to the liver damage caused by DON, few studies have been done on cytochrome P450 (CYP450s) and DNA methylation, and the role of DNA methylation in growth inhibition of piglets was also unclear.
Results

In the present study, piglets were randomly assigned to the following three different dietary treatments for 4 weeks: control diet, diet containing 1 mg DON/kg feed, and diet containing 3 mg DON/kg feed. Compared to the control group, elevated alanine aminotransferase activity and globulin level were observed in DON groups; however, aspartate aminotransferase activity was decreased in 3 mg/kg DON group. DON exposure increased the mRNA expression of CYP450s including CYP1A1, CYP1A2, CYP2B22, CYP2C33, CYP2D25, CYP2E1, CYP3A22 and CYP3A39, in which DNA methylation was involved in the regulation of the expression of these enzymes. By estimating the benchmark dose value of the metabolic enzymes, CYP1A1 was found to be the most sensitive metabolic enzyme to evaluate the clinical liver injury caused by DON. DON upregulated the expression of DNA methyltransferases (DNMT1 and DNMT3B) in a dose-dependent manner, thus increasing the level of 5-mC in the whole genome. Notably, DON downregulated the expression of nicotinamide n-methyltransferase, possibly reducing the weight of the piglets. Additionally, 1 mg/kg DON decreased the expression of galanin-like peptide (GALP), while 3 mg/kg DON significantly increased the level of GALP through DNA methylation, thus affecting the appetite of the piglets. DON can significantly reduce the methylation level of insulin-like growth factor 1 (IGF-1) promoter and thus increase its expression.
Conclusions

Taken together, increased CYP450 expression and DNA methylation are important mechanisms of liver injury and growth inhibition induced by DON, which provide future reference values determination of antagonistic toxicity.
Correlation Between Single Nucleotide Polymorphisms in Cxcr4 Microrna Binding Site and the Susceptibility to Knee Osteoarthritis in Han Chinese Population
Authors: Wang Yang , Li Yanlin , Jia Di , Zheng Jiali , Wang Guoliang
Published: June 2020

Background:This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) at the microRNA target sequence in CXCR4 and the susceptibility to knee osteoarthritis (KOA).Methods:A total of 305 patients with KOA and 305 healthy controls were recruited into this study. The genotypes of CXCR4 rs1804029 and rs17848060 loci were analyzed.Results:The susceptibility to KOA of CXCR4 rs1804029 G allele carriers was 1.33 times that of T allele carriers. The KOA susceptibility in individuals carrying T allele at CXCR4 rs17848060 locus was 1.38 times that of individuals carrying A allele (95% CI: 1.17-1.57, p < 0.001). The G allele at CXCR4 rs1804029 locus was the target of hsa-miR-146a-3p, while the A allele at CXCR4 rs17848060 locus could be targeted by hsa-miR-20a-3p. The plasma level of hsa-miR-146a-3p was lower in rs1804029 G allele carriers than T allele carriers, whereas plasma level of hsa-miR-20a-3p was higher in rs17848060 T allele carriers than A allele carriers.Conclusion:The SNPs at rs1804029 and rs17848060 loci in CXCR4 were significantly associated with the susceptibility to KOA in Han Chinese population.
Pseudomonas Putida as a Potential Biocontrol Agent Against Salmonella Java Biofilm Formation in the Drinking Water System of Broiler Houses
Authors: Maes Sharon , De Reu Koen , Weyenberg Stephanie Van , Lories Bram , Heyndrickx Marc , Steenackers Hans
Published: June 2020

Background: Environmental biofilms can induce attachment and protection of other microorganisms including pathogens, but can also prevent them from invasion and colonization. This opens the possibility for so-called biocontrol strategies, wherein microorganisms are applied to control the presence of other microbes. The potential for both positive and negative interactions between microbes, however, raises the need for in depth characterization of the sociobiology of candidate biocontrol agents (BCAs). The inside of the drinking water system (DWS) of broiler houses is an interesting niche to apply BCAs, because contamination of these systems with pathogens plays an important role in the infection of broiler chickens and consequently humans. In this study, Pseudomonas putida, which is part of the natural microbiota in the DWS of broiler houses, was evaluated as BCA against the broiler pathogen Salmonella Java.Methods: To study the interaction between these species, an in vitro model was developed simulating biofilm formation in the drinking water system of broilers. Mono- and dual-species biofilms were grown in 6-well microtiter plates and quantified based on bacterial counts and social interactions in mixed communities were determined by the cooperation criterion and biodiversity effect.Results: Dual-species biofilms of P. putida strains P1, P2, and P3 with S. Java were characterized by competitive interactions, independent of P. putida strain, S. Java inoculum density and application order. When equal inocula of S. Java and P. putida strains P1 or P3 were simultaneously applied, the interaction was characterized by mutual inhibition, whereas P. putida strain P2 showed an exploitation of S. Java. Lowering the inoculum density of S. Java changed the interaction with P. putida strain P3 also into an exploitation of S. Java. A further increase in S. Java inhibition was established by P. putida strain P3 forming a mature biofilm before applying S. Java.Conclusions: This study provides the first results showing the potential of P. putida as BCA against S. Java in the broiler environment. Future work should include more complex microbial communities residing in the DWS, additional Salmonella strains as well as chemicals typically used to clean and disinfect the system.
Real-Life Variability of Corneal Epithelium Thickness in Photorefractive Keratectomy
Authors: Barequet Dana , Levinger Eliya , Rosenblatt Amir , Levinger Samuel , Barequet Irina S.
Published: June 2020

PURPOSE: To evaluate the real-life epithelial thickness (ET) as measured intraoperatively by optical coherence pachymetry (OCP) in myopic eyes undergoing alcohol-assisted photorefractive keratectomy (PRK).METHODS: A retrospective review of patients who underwent alcohol-assisted PRK was performed. Data were abstracted on age, gender, contact lens (CL) wear, preoperative refractive errors, keratometry, topographic and ultrasonic pachymetry, and intraoperative OCP measurements before and after epithelium removal. The central ET was calculated by subtracting OCP measurement after epithelium removal from the OCP measurement prior to epithelium removal. RESULTS: The study comprised of 140 consecutive eyes from 70 patients. The mean age was 27.29 ± 6.57 years, 51.4% were females. CL was used in 80 eyes (57.1%). The mean sphere and spherical equivalent were -3.69 ± 2.74D and -3.36 ± 2.76D, respectively. The mean intraoperative ET was 59.49 ± 19.93µm (range, 15-150µm). Fifty-four percent of the eyes had an ET measurement above or below the range of 40-60µm. ET was significantly higher in the second operated eye compared to the first operated eye (p=0.006). There was no significant difference in thickness between genders (p=0.29) or association to CL-wear (p=0.11), and no correlation to patient age (p=0.18, rp=0.13), refractive errors (p>0.11, rp=-0.02-0.14), nor keratometry (p>0.64, rp=-0.01-0.02). Conclusion: The real-life assessment of intraoperative ET in alcohol-assisted PRK showed a high variability of the central corneal epithelium, with a significant difference between the first and second operated eyes. This difference may have implications when the epithelium is not included in the surgical planning in surface ablation.
What Factors Contribute to High Mechanical Strength of Tabia? Case Study of the Tabia from Coastal Forts Sites at Zhejiang, China
Authors: Zhang Cuisong , Zhang Bingjian , Cui Biao , Lin Guocong
Published: June 2020

Tabia is one of the most widely used construction materials in ancient China. In this work, the tabia samples from three coastal defense fort sites at Zhejiang Province, China, we analyzed to determine their component composition and physiochemical properties. The results show that these tabia samples exhibited high compressive strength, which could be as high as 4–9 MPa. Furthermore, the systematic analysis demonstrated that the high compressive strength was related to the following factors: 1) a suitable mass ratio of sand, lime, and clay; 2) an appropriate sand particle size ratio; and 3) the formation of hydrated calcium silicate (C-S-H). Moreover, sticky rice was also detected in the tabia samples. These findings are fundamentally important, which could be beneficial to further study of the craftsmanship of the coastal defense forts and could further provide essential guidance for the protection and restoration of the tabia relics.
Preserving the Endothelium in Saphenous Vein Graft with Both Conventional and No-Touch Preparation
Authors: Saito Toshiro , Kurazumi Hiroshi , Suzuki Ryo , Matsuno Yutaro , Mikamo Akihito , Hamano Kimikazu
Published: June 2020

Background Despite the inferior patency compared to arterial grafts, a saphenous vein graft (SVG) is widely used for coronary artery bypass grafting (CABG). A lower atherosclerosis rate and higher patency have been reported for SVG obtained via the no-touch technique (NT) than via conventional preparation (CV). Although CV-mediated endothelial dysfunction is implied, the precise mechanism underlying the higher patency with NT is poorly understood. Methods Human residual SVGs during CABG and SVG sections after autopsy were analyzed. The endothelial surface was observed using scanning electron microscopy (SEM) and blindly compared between CV and NT. The endothelial integrity was also analyzed with immunohistochemistry.Results Unexpectedly, the hyperfine structure on SEM was comparable between CV and NT before grafting, and microvillus, a characteristic of endothelium, was indistinguishable between them. von Willebrand Factor, an endothelial marker, was equally detected throughout the vascular wall in both groups from residual and postmortem sections.Conclusions The morphological integrity of the endothelium was successfully preserved in SVG with CV, even at an ultrastructural level. Although its functionality remains to be addressed, other factors than the endothelium may be involved in the high patency obtained by NT. The present findings suggest that the characteristics of NT and surgical methodology should be reconsidered.
Heterologous Expression of Arabidopsis rty Enhances Drought Tolerance in Strawberry (Fragaria × ananassa Duch.)
Authors: Li Maofu , Yang Yuan , Raza Ali , Yin Shanshan , Wang Hua , Zhang Yuntao , Dong Jing , Wang Guixia , Zhong Chuanfei , Zhang Hong , Liu Jiashen , Jin Wanmei
Published: June 2020

Background Strawberry ( Fragaria × ananassa Duch.) is an important fruit crop worldwide. It was particularly sensitive to drought stress because of their fibrous and shallow root systems. Mutation of Arabidopsis thaliana ROOTY ( RTY ) results in increased endogenous auxin levels and roots and shoot growth, but the effects of this gene in strawberry remain unclear. Results Here, we heterologously expressed Arabidopsis rty in strawberry plants and examined the effects of rty expression on the hormonal and physiological properties of the plants. Heterologous expression of rty induced IAA accumulation and increased the production of adventitious roots as well as trichomes on the abaxial leaf surface of the transgenic plants. Furthermore, the transgenic strawberry plants had increased ABA accumulation and stomatal closure. The transgenic strawberry plants exhibited enhanced water use efficiency and a reduced water loss rate. Additionally, peroxidase and catalase activities were significantly higher in the transgenic plants than in the untransformed controls, and the transgenic plants were more drought tolerant than the wild-type plants. Our results uncover a transgenic approaches can be used to overcome the inherent trade-off between plant growth and drought tolerance by enhancing water use efficiency and reducing water loss rate under water shortage conditions. Conclusions In this study, the rty gene improves hormone-mediated drought tolerance in transgenic strawberry. We demonstrated that the heterologous expression of rty in strawberry improved drought tolerance by promoting auxin and ABA accumulation. These phytohormones together brought about various physiological changes that improved drought tolerance via increased root production, trichome density, and stomatal closure. This study provides the basis for future genetic modifications of strawberry to improve drought tolerance.
What is the effect of stimulus complexity on attention to repeating and changing information in Autism?
Authors: Arora Iti , Bellato Alessio , Gliga Teodora , Ropar Danielle , Kochhar Puja , Hollis Chris , Groom Madeleine
Published: June 2020

Background

Previous research has suggested that atypical attention in autism might be driven by a preference for sameness over novelty. There is also evidence of slower habituation to a repeating stimulus in autism. It is not known whether slower habituation is driven by atypically slower processing of repeating information or whether it is a manifestation of an attentional bias away from novelty towards sameness.

Methods

We adapted an existing eye-tracking task and measured eye movements to two streams of stimuli presented simultaneously, one each in the left and right sides of the screen. One stimulus repeated while the second stimulus changed across trials. We manipulated the complexity of the stimuli between three conditions: a simple shapes condition, a social (smiling faces) condition and a complex non-social condition (clocks with moving parts). Using the slope of change in the longest look duration to each stimulus over trials, we measured whether autistic features were associated with slower habituation (to the repeating stimulus) and/or reduced attention to novelty (changing stimulus) over trials, and whether these effects were more pronounced in conditions with higher stimulus complexity (social and non-social complex conditions) compared with low complexity (simple shapes condition). We presented the task to two independent samples of children: 7-15 years old children and adolescents (n=103) diagnosed with Autism, ADHD or co-occurring Autism and ADHD and neurotypical children (Study 1); neurotypical children (n=64) with varying levels of subclinical traits of Autism (Study 2).

Results

Across the two studies, autistic features were associated with positive slopes of change in look durations (longer looks over time) to the repeating stimulus and negative slopes (shorter looks over time) to the changing stimulus, only in conditions with higher stimulus complexity. Negative slopes to the changing stimulus in conditions of higher stimulus complexity was associated with higher severity of social interaction difficulties (in Study 1).

Conclusions

Reduced attention to novelty in autism might partly be driven by difficulties in processing more complex information, which might contribute to the development of social interaction difficulties in autism. Replication in larger samples and longitudinal research using younger age groups are recommended.
Slit2-Robo1 signaling enhances nasopharyngeal carcinoma metastasis via PI3K/AKT/β-catenin pathway
Authors: Shi Mei , Zhao Li-Na , Ma Rui , Yang Hua , Liu Chang-Hao , Hu Jing
Published: June 2020

Background Distant metastasis remained the major cause of mortality in nasopharyngeal carcinoma (NPC) receiving radiotherapy despite favorable locoregional control in the past decades. Tumor microenvironment plays a critical role in tumor progression by secreting factors that regulate cancer cell metastasis. We explored the role of secreted protein Slit2 in NPC metastasis and the underlying mechanisms. Methods Colony formation assay were determined the opitimal dose. Using real-time PCR, western blotting, and ELISA, we detected the expression of Slit2 in NPC cells and in supernatant. Cell migration assay and cell invasion assay were examined the role of Slit2 in promoting metastasis of NPC cell lines. Western blotting, immunofluorescence staining, transwell and Co-IP assay et al. were performed to explore the detailed molecular mechanism of Slit2 in NPC. Finally, we estimated the effects on Slit2-shRNA NPC cells in vivo tumor metastasis experiment Results We found that irradiated dying NPC cells could secrete Slit2 to enhance the metastatic ability of surviving NPC cells. Mechanistic study showed that Slit2 interacted with its cognate Robo1 receptor, which activated PI3K/Akt pathway and enhanced the nuclear translocation of β-catenin to promote NPC metastasis. Finally, we demonstranted that knockdown of Slit2 in NPC cells significantly suppressed lung and liver metastasis. Conclusion Slit2, a secreted factor released from irradiated dying NPC cells could promote metastasis of living/resistent NPC cells through PI3K/AKT/β-catenin pathway. Tumor microenvironment altered by irradiated dying cancer cells may be promising target to treat cancer metastasis.
Hsa_circRNA_000166 facilitated cell growth and limited apoptosis through targeting miR-326 / LASP1 axis in colorectal cancer
Authors: Hao Qin , Zhang Zhongtao
Published: June 2020

Background: Circular RNAs(circRNAs) belong to non-coding RNAs and widely expressed in a variety of cell species, including cancers. However, the function and mechanism of circRNAs in colorectal cancer (CRC) has not been well investigated.
Methods: Microarray data of CRC from Gene Expression Omnibus (GEO) database was used to obtain DEGs. QRT-PCR and western blot assay were performed to determine the mRNA and protein levels of multiple genes, respectively. Cell growth and apoptosis assay were conducted to measure CRC cell proliferation and apoptosis, respectively. Luciferase assay was utilized to confirm the direct interaction between hsa_circRNA_000166 and miR-326.
Results: We downloaded and analyzed the circRNA expression profile of CRC from the GEO database and identified 181 differentially expressed circRNAs between 10 pairs of CRC and adjacent normal tissues. Interestingly, we observed that the expression of hsa_circRNA_000166 was the top increased among these circRNAs. Then, we confirmed an upregulation of hsa_circRNA_000166 in CRC tissues and cell lines and observed that higher expression of hsa_circRNA_000166 was associated with poor 5-year survival rate of patients with CRC. Cell growth and apoptosis assay revealed that hsa_circRNA_000166 regulated the cell growth and apoptosis in CRC cell lines. Furthermore, we identified that hsa_circRNA_000166 targeted miR-326/LASP1 pathway using bioinformatic analysis and luciferase reporter assay. Finally, overexpression of miR-326 could sufficiently rescued the aberrant cell growth and apoptosis in CRC cell lines.
Conclusion: Taken together, our results indicated that downregulation of hsa_circRNA_000166 inhibited the cell growth and facilitated apoptosis during CRC development by sponging miR-326 / LASP1 pathway.
QTL mapping and candidate gene identification in rice using a Kalarata-Azucena population under salt stress
Authors: Ocampo Marjorie P. de , The Ho Viet , Thomson Michael J. , Mitsuya Shiro , Yamauchi Akira , Ismail Abdelbagi M
Published: June 2020

Background

Salt stress is a major constraint across large rice production areas in Asia, because of the high sensitivity of modern rice varieties. To identify quantitative trait loci (QTL) associated with salt tolerance in rice, we developed an F2 population from a cross between the salt-tolerant landrace, Kalarata, and the salt-sensitive parent, Azucena. An F2 population was used for DNA extraction, and F2:3 families from this population were screened in a phytotron in a saline nutrient solution at the seedling stage.
Results

After 2 weeks at an EC of 12 dS m− 1, the F2:3 families were scored for salt tolerance using IRRI’s Standard evaluation system (SES). Growth, biomass, Na+ and K+ concentrations in leaf tissues, and chlorophyll concentration were determined. A genetic linkage map was constructed with 151 SSRs and InDel markers, which cover 1463 cM with an average distance of 9.69 cM between loci. A total of 13 QTL were identified using Composite Interval Mapping for 16 traits. The short arm of chromosome 1 had the highest density of QTL associated with salt tolerance, which coincides with the Saltol locus; emphasizing the importance of this locus for candidate gene discovery and for use in rice breeding. Several novel QTL were identified on other chromosomes.
Conclusions

The novel QTL identified in this study constitute future targets for molecular breeding, to combine them with other QTLs identified before, for higher and stable performance of rice varieties in salt affected soils. Candidate genes for the large effect QTL on chromosome 3 were found to be involved in diverse biological processes, cellular components, and molecular functions. Several candidate genes in this locus were functionally associated with salt stress tolerance and should further be considered for genetic improvement of rice varieties.
Estimation of the R0 factor of the SIR Model in Italy and some its regions as consequence of the pandemic Sars-Covid-2
Authors: Rinzivillo Calogero , Conte Sergio , Kaleagasioglu Ferda , Morderniz Cengiz , Conte Elio
Published: June 2020

We compute the factor R0(t) by using the SIR model in Italy and its some regional countries in the period April May 2020. We find that it is descending to a minimum value of 0.22 in Italy and respectively of 0.10,0.15 ,and 0.07 for each region respectively
A six-mRNA signature-based model for the prognosis prediction of breast cancer
Authors: Huang Yan , Wan Xia , Wang Shixiang
Published: June 2020

BackgroundDue to the lack of predictors, high mortality and poor prognosis have always been a serious threat to the breast cancer (BC) patients. Accumulating studies have shown that molecular markers which affect the tumor microenvironment (TME) play an important role in the development of cancer. Here, we aim to use machine learning to identify a new prognostic gene signature and independent prognostic factors related to BC survival through comprehensive bioinformatics analysis.Results This 6-mRNA signature-based model is not only an important indicator to predict the prognosis and survival of BC, but also a potential indicator to monitor the clinical therapeutic effect with certain clinical significance.Conclusions A new 6-gene prognostic signature was discovered and it is a promising independent predictor. The 6 feature genes can function as important biomarkers for BC clinical treatment. At the same time, our study also provides a new insight to explore the molecular mechanism of TME and immune cells that influence BC progress.
Investigation On The Influence of A Novel Redirector With By-Pass Damping On The Performance of Load Sensing Steering System
Authors: Wang Yu-Qi , Liu Xin-Hui , Chen Jin-Shi , Huo Dong-Yang
Published: June 2020

The load sensing steering system of articulated loaders is prone to large pressure shock and oscillation during steering operations, affecting the stability of the steering system. To improve this phenomenon, an optimized structure of the redirector with by-pass damping is proposed, which adding orifices and throttle grooves to the original redirector. In the study, to control the steering load and working conditions, the steering load of the loader is replaced by using a pressure regulating valve. The simulation and experimental results shows that, compared with the traditional redirector, using the novel structure redirector with by-pass damping ensures good load sensing characteristics, the peak output pressure shock caused by the load unit step signal decreases from 65.04bar to 56.35bar, with a decrease rate of 13.4%, reducing the pressure oscillation of the hydraulic system. The pressure fluctuation time can be reduced from 2.09s to 1.6s, with a decrease rate of 23.4%, the output pressure oscillation decays faster, the smoothness of the steering operation is significantly improved.
ZİNANIN HUKUK-İÇİ VE HUKUK-DIŞI SOYKÜTÜĞÜ
Authors: SAĞLAM Rabia
Published: June 2020

“Gayrı meşru cinsel ilişki” anlamına gelen zina, ataerkil sembolik düzende düzenleyici bir normdur. Makalede ataerkil sembolik düzen kavramını Butler’ın düşüncelerine atıfla tartışacağım. Butler, ensest yasasına dayanan Lévi-Strauss’un ve Lacan’ın yapısalcı söyleminin toplumsal/sembolik normların evrensel ve ideal biçimi olarak formüle edildiğini belirtir. Bu evrensel yapıdaki ortak nokta, eşit ve özerk kadın özneye yer olmamasıdır. Diğer ifadeyle, kadın özne ataerkil sembolik düzende ikincil konumdadır. Ataerkil sembolik düzen normlarının ve zinanın toplumsal/sembolik anlamının hukuki norm ve yorumları şiddet edimleriyle içeriden ve dışarıdan etkilediğini açıklayacağım. Cover’ın “hukuki şiddet”, Fricker’ın “epistemik adaletsizlik” kavramlarını analiz ederek, common-law’da zina tarihine kısaca değinerek zinaya ilişkin hukuki norm ve yorumları eleştirel bir şekilde ele alacağım. Zina normu Türkiye’de özel boşanma nedeni olarak Medeni Kanunda düzenlenmiştir. Dolayısıyla hukuki şiddetin Türkiye’deki zina yargısıyla nasıl etkileşim içinde olduğunu ayrıntılı bir şekilde tartışmak gerekir. Türkiye Aile Mahkemelerinin ve Yargıtayın zinaya ilişkin kararlarını inceleyerek, kusur-temelli boşanma sürecinde yargısal kararların nasıl yorumlandığını ve kadın öznelere hukuki şiddetin nasıl icra edildiğini göstermeye çalışacağım. Yargıtayın yerleşik içtihadına göre, boşanma davalarında tazminatın ve evlilikle ilgili kazanım miktarının belirlenmesi açısından kadın eşin zinası kocanın aile-içi şiddetinden daha ağır kusur kabul edilmektedir.
Analisis Soal PLSV pada Buku Ajar Matematika dari Kurikulum 1994 hingga Kurikulum 2013
Authors: Raditya Aji , Iskandar Ratu Sarah Fauziah
Published: June 2020

Buku Ajar matematika memainkan peran yang sangat penting dalam kegiatan belajar-mengajar matematika di sekolah dan soal-soal yang terdapat pada buku ajar biasanya digunakan oleh para siswa untuk latihan secara mandiri. Tujuan dari penelitian ini adalah menganalisis jenis soal pada buku ajar matematika yang digunakan dari tahun 1994 hingga 2017 di Indonesia, khususnya pada materi persamaan linear satu variabel. Metode yang digunakan pada penelitian ini merupakan metode analisis enam dimensi, yang terdiri dari: aktivitas matematis, tingkat kesulitan soal, jenis jawaban yang diharapkan, situasi kontekstual, jenis respon dan jenis pertanyaan matematis. Teknik pengumpulan data dilakukan dengan menganalisis dan mendeskripsikan jenis soal pada buku ajar matematika yang digunakan dari tahun 1994 hingga 2017. Hasil dari penelitian ini adalah soal pada buku ajar matematika untuk materi PSLV tidak memilik jenis yang beragam. Jenis soal pada buku ajar masih banyak berupa soal yang menghitung atau menggunakan berbagai operasi hitung, menerapkan langsung pengetahuan atau keterampilan dasar serta tanpa konteks dalam kehidupan sehari-hari. Selain itu, soal yang ada juga merupakan soal dengan jenis jawaban tertutup, soal yang hanya membutuhkan jawaban tanpa alasan serta soal dengan prosedur tunggal.
ANALISIS KEMAMPUAN BERPIKIR KRITIS SETELAH PENERAPAN PROBLEM BASED LEARNING BERBANTUAN LEMBAR KERJA PESERTA DIDIK BERMUATAN ETNOSAINS
Authors: . Defiyanti , Sumarni Woro
Published: June 2020

Kemampuan berpikir kritis merupakan salah satu kompetensi yang dibutuhkan dalam menghadapi tantangan abad ke 21. Beberapa peneliti menyampaikan bahwa salah satu model pembelajajaran yang dapat mengembangkan kemampuan berpikir kritis adalah Problem Based Learning (PBL). Penelitian ini bertujuan untuk menganalisis kemampuan berpikir kritis dan respon peserta didik setelah diterapkannya model PBL berbantuan LKPD bermuatan etnosains pada materi reaksi redoks. Penelitian ini adalah  studi kasus dengan desain single holistic. Penelitian ini dilakukan pada peserta didik kelas X-MIPA 1 SMAN 10 Semarang yang berjumlah 36 orang yang dipilih secaara purposive sampling. Data dikumpulkan melalui teknik tes, observasi dan angket yang telah diuji validitas dan reliabilitasnya. Hasil penelitian menunjukkan bahwa rata-rata kemampuan berpikir kritis peserta didik adalah sebesar 62,6 dan termasuk dalam kategori cukup. Indikator berinteraksi dengan rang lain dapat berkembang dengan baik, namun indikator menentukan induksi masih dalam kategori rendah. Peserta didik juga  memberikan respon positif terhadap penerapan model PBL berbantuan LKPD bermuatan etnosains.
PROFIL KOMPETENSI 4C’S SISWA DENGAN PEMBELAJARAN MODEL READING-CONCEPT MAP-JIGSAW PADA MATERI SISTEM EKSKRESI
Authors: SHOLIKHA ARI IVAYANTI ARDIK
Published: June 2020

Penelitian ini bertujuan untuk mengetahui pengaruh pembelajaran model reading-concept map-jigsaw pada materi sistem ekskresi terhadap kompetensi 4C’s siswa SMA N 2 Ungaran. Penelitian ini adalah penelitian Quasi Experiment dengan desain penelitian Non-Equivalent Control Group Design. Populasi yang digunakan adalah seluruh kelas XI MIPA SMA N 2 Ungaran. Sampel yang digunakan adalah kelas XI MIPA 2 sebagai kelas kontrol dan XI MIPA 3 sebagai kelas eksperimen. Teknik pengambilan sampel menggunakan cluster random sampling. Rata-rata nilai posttest kelas XI MIPA 2 adalah 80,76 dan kelas XI MIPA 3 adalah 90,21. Hasil uji independent sample t test  menunjukkan terdapat perbedaan rata-rata yang signifikan antara nilai posttest kelas eksperimen dan kontrol, dengan nilai signifikansi 0,000 0,05. Uji n-gain dilakukan untuk mengetahui peningkatan keterampilan berpikir kritis siswa, yang menunjukkan hasil rata-rata n-gain kelas XI MIPA 2 adalah 0,64 (sedang) dan rata-rata n-gain XI MIPA 3 adalah 0,81 (tinggi). Rata-rata nilai kuesioner keterampilan berpikir kreatif pada kelas XI MIPA 2 adalah 70,73 dan kelas XI MIPA 3 adalah 75,21. Hasil uji independent sample t test menunjukkan terdapat perbedaan rata-rata yang signifikan antara nilai kuesioner kelas eksperimen dan kontrol, dengan nilai signifikasi 0,008 0,05. Rata-rata nilai observasi keterampilan komunikasi pada kelas XI MIPA 2 adalah 74,77 dan kelas XI MIPA 3 adalah 85,53. Rata-rata nilai observasi keterampilan kolaborasi pada kelas XI MIPA 2 adalah 77,03 dan kelas XI MIPA 3 adalah 83,88. Hasil uji independent sample t test menunjukkan terdapat perbedaan rata-rata yang signifikan antara hasil nilai observasi keterampilan komunikasi dan kolaborasi kelas eksperimen dan kontrol, dengan nilai signifikasi 0,000 0,05. Hasil ini diperkuat dengan tanggapan guru dan siswa yang memberikan respon yang positif terhadap model pembelajaran remap jigsaw. Berdasarkan hasil penelitian disimpulkan pembelajaran model reading-concept map-jigsaw pada materi sistem ekskresi berpengaruh terhadap kompetensi 4C’s siswa SMA N 2 Ungaran. Kata kunci: kompetensi 4C’s, model reading-concept map-jigsaw, sistem ekskresi.
A globális élelmezésbiztonság megközelítési lehetőségei
Authors: Gibárti Sára
Published: June 2020

Jelen tanulmány fő célja a globális élelmezésbiztonság szegmenseinek és értelmezési kereteinek vizsgálata. Az elemzés során kiemelt figyelmet kapott az élelmezésbiztonság megszűnéséből következő élelmezés-bizonytalanság okainak, fokozatainak vizsgálata, valamint a releváns nemzetközi szervezetek által alkalmazott mérési lehetőségek és technikák ismertetése. Mindezeken felül hangsúlyos az élelmezésbiztonság fogalmi változásainak ismertetése, továbbá a humán biztonság és az élelmezésbiztonság közötti párhuzam szemléltetése. Ehelyütt célszerű tisztázni, hogy a tanulmány fejezeteiben használt élelmezés-bizonytalanság kifejezés az élelmezésbiztonság, az élelmiszerhez való hozzáférés, valamint az élelmiszerrel való ellátottság megszűnésére, megszűnésének veszélyeire vonatkozik.
Positioning of University North for the contemporary labour market
Authors: Hunjet Anica , Milković Marin , Vuković Dijana
Published: June 2020

The positioning of higher education institutions, taking into consideration social developments as well as changes in education, is essential to the development and growth of an education and knowledge-based economy. The dynamics of modern economy and the scientific and technological revolution have created a complex environment and imposed a continuous need for adaptation and innovation in the field of education and knowledge. The education system, as the primary driving force of growth, needs to continuously review its own efficiency and competitiveness. The aim of the paper is to underline the position of University North in the current higher education landscape in Croatia as a thriving and successful university which is setting the bar and creating new values and expectations to meet the challenges and opportunities of the current labour market. The strategic concept pursued by University North is learning-oriented teaching, which is responsive to changes in the environment, new student needs, new occupational profiles, new partners, market demands and the very factors that drive students to learn. To do this successfully, the University has to adopt the latest advancements in technology for learning, and introduce new undergraduate, graduate and post-graduate study programmes. The paper lists new study programmes that meet the student as well as labour market needs. University North occupies a distinctive position in the market owing to its innovative study programmes and active learning.
The changing nature of the water–energy nexus in urban water supply systems: a critical review of changes and responses
Authors: Wu Wenyan , Maier Holger R. , Dandy Graeme C. , Arora Meenakshi , Castelletti Andrea
Published: June 2020

This paper provides a review of the changing nature of the water–energy nexus in urban water supply systems (UWSSs) due to the primary long-term drivers of climate change, population growth and technological development from the ‘energy for water’ perspective. We identify both the physical changes in UWSSs, as well as the changes in the attributes of the system, both of which contribute to the changing nature of the water–energy nexus. We provide an overview of responses to this change in the water–energy nexus through the lens of four application areas, namely long-term planning, system design, system operation and system rehabilitation, based on the review of 52 papers. Ten responses in three categories are found to be commonly considered in each of the four application areas. The three categories are energy or greenhouse gas reduction, integrated modelling and planning, and improving social benefits. The main drivers of these responses may vary with the application area. Based on the review outcomes, we outline the gaps in the responses in relation to the changing nature of the water–energy nexus in UWSSs, providing directions for future research on improving UWSS efficiency considering the long-term drivers.
Comparison of Postprandial Serum Triglyceride and Apolipoprotein B Concentrations between the Two Phases of Menstrual Cycle in Healthy Women
Authors: Tzeravini Evangelia , Tentolouris Anastasios , Eleftheriadou Ioanna , Chaviaras Nikolaos , Kolovou Genovefa , Apostolidou-Kiouti Fani , Stratigakos Eleftherios , Tentolouris Nikolaos
Published: June 2020

Background:

Sex hormones influence lipoprotein metabolism; whether the hormonal fluctuation
during normal menstrual cycle has impact on non-fasting lipids remains unclear.

Objective:

To examine the differences in postprandial triglyceride, apolipoprotein B (ApoB) and nonhigh
density lipoprotein cholesterol (non-HDL-C) concentrations using a standardized fat tolerance test
during the 2 menstrual cycle phases.

Methods:

We enrolled 25 healthy, menstruating women. Each of them underwent a fat tolerance test
during the 2 phases of the menstrual cycle. Blood samples were collected at baseline and up to 6 h postprandially.
Differences in serum triglycerides, ApoB and non-HDL-C between the 2 phases were assessed.
The incremental area under the curve (iAUC) was calculated. Reproducibility of the measurements
was tested using the intraclass correlation coefficient (ICC) and coefficient of variation (CV).

Results:

Serum triglyceride concentrations increased postprandially in both phases and the values were
higher during the follicular compared with the luteal phase; however, the overall triglyceride response
expressed as iAUC [median value (interquartile range)] did not differ between the follicular and the
luteal phase [54.0 (-26.5, 107.0) and 48.0 (6.0, 114.5) mg x h/dl, respectively, p=0.64]. Serum ApoB
concentrations did not increase postprandially and the overall ApoB response was not different between
the 2 phases. Non-HDL-C concentrations changed postprandially, but the overall response was not different
between the 2 phases of the menstrual cycle. Reproducibility of the measurements was moderate:
ICC 0.689-0.848 for triglycerides, 0.721-0.771 for ApoB, 0.457-0.867 for non-HDL-C, and %CV >8 for
all parameters.

Conclusion:

Serum triglyceride levels were higher during the follicular compared with the luteal phase
after standardized meal consumption, but the overall postprandial triglyceride response did not differ
between the 2 phases. Postprandial ApoB and non-HDL-C serum concentrations were not affected by
the menstrual cycle.
Substrate Integrated Waveguide Based Leaky Wave Antenna for High Frequency Applications and IoT
Authors: Sharma Manvinder , Singh Harjinder
Published: June 2020

Background & Objective:

Internet of things devices managed by wireless networks so
that higher data rates can be achieved. With increase in demand of usage of Internet microwave signals
are capable for delivering the demand. However these high frequency waves needs a waveguide
to propagate otherwise they get affected due to atmospheric attenuation and rain fade. A modified
structure of rectangular waveguide is used named as Substrate Integrated Waveguide (SIW).

Methods:

In this paper, the work has been carried out taking SIW and Leaky Wave Antenna. The dielectric
substrate was taken as carbon. Modeling of SIW Leaky wave Antenna is done by making C
shaped Slots. Design steps for modeling LWA were orderly pursued also optimized with various
equations followed by Finite Element Method based modeling. A range of frequency as input is taken
from 7 GHz to 11 GHz to take the analysis of design modeled.

Results:

The result shows the electric field intensity and radiation pattern is directly proportional with frequency
while the return loss is acceptable for applied frequency range.

Conclusion:

The proposed antenna can radiate in omni directional radiation pattern hence can be used to
connect devices with IoT.
HUBUNGAN STATUS HIDRASI DENGAN VO2 MAX PADA ATLET SEPAK BOLA
Authors: Pratama Ari Widya Putra , Rismayanthi Cerika
Published: June 2020

Masih banyak atlet yang kurang memperhatikan tingkat kebugaran jasmaninya agar dapat mencapai performa terbaik, dan juga pemenuhan cairan dalam tubuh yang masih dianggap tidak penting. Berdasarkan hal tersebut penelitian ini bertujuan untuk mengetahui hubungan status hidrasi terhadap VO2max pada atlet sepak bola.Penelitian ini menggunakan metode korelasional dengan pendekatan deskriptif kuantitatif. Instrumen dalam penelitian ini berupa tes status hidrasi menggunakan kolorisasi warna urin atau PURI dan VO2max mengunakan tes balke (lari 15 menit). Subjek penelitian yang digunakan adalah atlet sepak bola Beringin Putra Football Club Wonosobo yang berjumlah 18 atlet. Teknik analisis data menggunakan korelasi product moment dan analisis regresi berganda dengan taraf signifikansi 5 %.Berdasarkan hasil analisis hubungan status hidrasi dengan VO2max diperoleh harga rhitung = -0,794 > r(0.05)(17) = 0,389, hasil tersebut disimpulkan ada hubungan antara status hidrasi terhadap VO2max pada atlet sepak bola Beringin Putra Football Club Wonosobo.
PEMBERIAN MADU SEBELUM AKTIVITAS FISIK INTENSITAS SEDANG TERHADAP KADAR MALONDIALDEHID PLASMA TIKUS WISTAR
Authors: Apriyanto Krisnanda Dwi
Published: June 2020

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian madu sebelum aktivitas fisik intensitas sedang terhadap penurunan kadar malondialdehid (MDA) plasma pada tikus jantan.Penelitian yang dilakukan adalah eksperimental laboratorium dengan menggunakan rancangan posttest dengan kelompok kontrol (posttest only control group design) yang dilakukan selama 7 hari. Sampel penelitian ini menggunakan 20 ekor tikus putih Wistar jantan (Rattus norvegicus). Tikus dibagi menjadi 2 kelompok secara acak dan masing-masing kelompok terdiri dari 10 tikus. Kedua kelompok adalah: K0 = kelompok kontrol dan K1 = kelompok pemberian madu dosis 2,5 g/kg BB. Aktivitas fisik intensitas sedang dilakukan dengan cara merenangkan tikus selama 70% dari kemampuan maksimal tikus berenang dan diberikan tambahan beban 6% dari berat badan tikus. Madu diberikan satu kali setiap hari selama 7 hari dilakukan melalui sonde. Data dianalisis menggunakan program statistik SPSS 16.Hasil penelitian menunjukkan bahwa rata-rata kadar MDA plasma dalam kelompok K0 adalah 12,02 ± 1,85 nmol/ml dan 9,89±0,9 nmol/ml pada kelompok K1. Uji analisis independen t-test menunjukkan perbedaan yang signifikan p = 0,007 (p <0,05). Terjadi penurunan kadar MDA plasma sebesar 17,72%. Pemberian madu dengan dosis 2,5 g/kg BB mengakibatkan penurunan yang signifikan terhadap kadar MDA. Hasil penelitian ini dapat dijadikan dasar penelitian lebih lanjut untuk mengetahui penggunaanya pada manusia.
PENGARUH LATIHAN DUMBELL-THERA BAND TERHADAP DAYA TAHAN OTOT LENGAN DAN AKURASI MEMANAH PADA ATLET PANAHAN
Authors: Yachsie Betrix Teofa Perkasa Wibafied Billy
Published: June 2020

Program latihan Dumbell-Thera Band kepada atlet panahan Kabupaten Banyumas di teliti karena ada beberapa pelatih dan atlet masih belum mengerti mengenai tujuan diberikannya latihan Dumbell- Thera Band. Penelitian ini bertujuan untuk mengetahui pengaruh latian dumbell-thera band terhadap daya tahan otot lengan dan akurasi memanah pada atlet panahan Kabupaten Banyumas. Desain penelitian ini adalah penelitian eksperimen. Metode yang digunakan adalah penelitian eksperimen semu. Disain yang digunakan dalam penelitian ini dengan menggunakan rancangan “One Group Pretest-Posttest Design. Instrumen yang digunakan adalah tes dan pengukuran akurasi dengan cara memanah jarak 30 meter dan daya tahan otot lengan menggunakan alat ukur Holding Bow Test. Populasi dalam penelitian ini adalah atlet maupun pengurus panahan Kabupaten Banyumas yang berjumlah 85 orang dengan sampel dalam penelitian ini berjumlah 12 orang. Teknik analisis data menggunakan uji t paired sample t test. Hasil penelitian dan pembahasan sebelumnya dapat diperoleh nilai uji t pada akurasi memanah diketahui nilai t hitung (9,869) > t tabel (1,80) dan uji t pada Daya Tahan Otot Lengan diperoleh nilai t hitung (8,812) > t tabel (1,80). Dengan demikian, dapat disimpulkan ada pengaruh latihan dumbell-thera band terhadap daya tahan otot lengan dan akurasi memanah pada atlet panahan Kabupaten Banyumas. EFFECTS OF DUMBBELL-THERA BAND EXERCISE TOWARDS THE ARM MUSCLE ENDURANCE AND ARCHERY ACCURACY IN ARCHERY ATHLETES AbstractThe Dumbell-Thera Band training program for Banyumas Regency archery athletes was examined because there are several trainers and athletes who still do not understand the purpose of the Dumbell-Thera Band training. This study aims to determine the effect of dumbbell-thera band exercises on arm muscle endurance and archery accuracy in archery athletes in Banyumas Regency The design of this research is experimental research. The method used is quasi-experimental research. The design used in this study using the design of "One Group Pretest-Posttest Design. The instrument used was a test and measurement of accuracy by arching a distance of 30 meters and endurance of the arm muscles using a measuring instrument Holding Bow Test. The population in this study were 85 athletes and administrators of Banyumas Regency with 12 people as the sample in this study. The data analysis technique used paired sample t test. The results of previous studies and discussions can be obtained t test value on archery accuracy known t count value (9.869)> t table (1.80) and t test on Arm Muscle Endurance obtained t value (8.812)> t table (1.80 ). Thus, it can be concluded that there is an influence of dumbbell-thera band exercises on arm muscle endurance and archery accuracy in Banyumas Regency archery athletes.