bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular interactions of some phenolics with 2019-nCoV and related pathway elements
Authors: İSTİFLİ Erman Salih , ŞIHOĞLU TEPE Arzuhan , SARIKÜRKCÜ Cengiz , TEPE Bektas
Published: July 2021

As of June 2021, the novel coronavirus disease (SARS-CoV-2) resulted in 180 million cases worldwide and resulted in the death of approximately 4 million people. However, an effective pharmaceutical with low side effects that can be used in the treatment of SARS-CoV-2 infection has not been developed yet. The aim of this computational study was to analyze the interactions of twenty-two hydroxycinnamic acid and hydroxybenzoic acid derivatives with the SARS-CoV-2 receptor binding domain (RBD) and host organism's proteases, transmembrane serine protease 2 (TMPRSS2), and cathepsin B and L (CatB/L). According to the RBCI analysis, the ligands with the highest affinity against 4 enzymes in the molecular docking study were determined as 1-caffeoyl-β-D-glucose, rosmarinic acid, 3-p-coumaroylquinic acid and chlorogenic acid. It has also been observed that these compounds interacted more strongly with spike RBD, CatB and CatL enzymes. Although the top-ranked ligand, 1-caffeoyl-β-D-glucose, violated the drug-likeness criteria at 1 point (NH or OH>5) and ADMET in terms of AMES toxicity, the second top-ranked ligand rosmarinic acid neither violated drug-likeness nor exhibited incompatibility in terms of ADMET. In conclusion, with its anti-inflammatory properties, rosmarinic acid can be considered and further investigated as a plant-based pharmaceutical that can offer a treatment option in SARS-CoV-2 infection. However, our findings should be supported by additional in vitro and in vivo studies.
Science education for blind and visually impaired children
Authors: Plazar Janja , Meulenberg Cécil J. W. , Kermauner Aksinja
Published: July 2021

Nowadays, science education is based predominantly on the principle of constructivism, according to which children should be active participants in the learning process and construct their knowledge based on experience. For blind or visually impaired children, science education methods and educational tools must be adapted according to their perceptual needs, in order for these children to be active participants in the learning process. The aim of the current paper is to describe the latest view on active and inquiry-based learning in science education for blind or visually impaired children while simultaneously minimizing misconceptions. Further, the paper compiles the recent research that enables prosperous and high-quality adaptive educational approaches and tools. Thus, the content of this paper will be useful for both science teachers and researchers of inclusive classrooms.
Definiranje i uporaba nazivlja za e-izvedbu nastave
Authors: Nemeth-Jajić Jadranka , Jukić Tonća
Published: July 2021

Nastava koja se zbog pandemije uzrokovane koronavirusom u hrvatskim školama i na hrvatskim sveučilištima u drugom polugodištu školske odnosno u ljetnom semestru akademske godine 2019./2020. odvijala na mreži u javni i stručni diskurs unijela je različite, katkada istoznačne, katkada bliskoznačne, katkada nedovoljno precizne nazive, što dovodi do potrebe preispitivanja njihova značenja i opsega pojma na koji se oni odnose. Kako bi se pridonijelo preciznijoj uporabi nazivlja za e-izvedbu nastave, u ovome radu pozornost je stoga ponajprije posvećena definiranju sedam izabranih naziva, a potom su postupkom pretraživanja mrežnih stranica na hrvatskome jeziku po ključnim riječima izdvojeni primjeri njihove uporabe. Posrijedi su nazivi e-učenje, e-poučavanje, e-nastava, mrežna nastava, online nastava, virtualna nastava i nastava na daljinu.
La escucha chamánica de la tierra como curación del alma
Authors: Pérez Gil Paola Andrea , Salgado Soto Sandy , Juyar Carolina , León Romero Luis Eduardo
Published: July 2021

Ante una ciencia mal-tratada desde su interior, un ojo enajenado y confundido en su visión, un ser humano cansado y desconfiado de la misma explicación, un mundo necesitado de comprensión y cuidado, ante unos cuantos insistentes de vivir en unos tiempos y espacios fragmentados, aparece la necesidad de escuchar de nuevo a lo propio, a lo primero y fundante como fuerza de transformación. Así, las siguientes letras reconocen un camino fenomenológico y contemplativo en la Gran Madre, la Hytcha Guaia, la Pachamama, el primer gran útero, matriz sagrada que alimenta y nutre lo humano en toda su manifestación.Para la psicología, saber de psyque, de alma, su tarea también está en mirarse, recuperarse y a través de un logos trascendente, integrativo, volver a la sensible y sentida escucha de lo divino como curación, por ello su afirmación a lo mágico, chamánico, potente y sagrado del conocimiento telúrico (de tierra), a la medicina que en ella habita y su sanación. La propuesta es el gran camino de andar la tierra, de sentir, escuchar y estar en conciencia de raíz, un camino de cuidado que constata en cada ritual y experiencia la fuerza espiritual de nuestro saber ancestral indígena como primera y perenne ciencia.
Persepsi Mahasiswa Terhadap Kualitas Sistem, Kualitas Informasi, dan Kualitas Layanan Elearning UIN Walisongo (Studi Kasus Mata Kuliah Manajemen Sistem Informasi)
Authors: Bakhri Syaiful
Published: July 2021

Penelitian ini bertujuan untuk mengetahui persepsi mahasiswa terhadap kualitas sistem, kualitas informasi, dan kualitas layanan pada elearning UIN Walisongo Semarang. Studi kasus penelitian ini pada matakuliah manajemen sistem informasi jurusan Manajemen Pendidikan Islam (MPI) di Fakultas Ilmu Tarbiyah dan Keguruan (FITK) UIN Walisongo Semarang. Metode yang digunakan adalah observasi di lapangan secara langsung dan wawancara dengan mahasiswa MPI. Hasil penelitian ini menunjukan bahwa kualitas sistem pada elearning UIN Walisongo, memudahkan mahasiswa dalam proses pembelajaran. kualitas informasi pada elearning UIN Walisongo memberikan informasi tentang materi dan tugas perkuliahan, sedangkan kualitas layanan pada elearning UIN Walisongo sudah disediakan media tutorial dalam bentuk video dan PDF, serta tersedianya layanan helpdesk untuk membantu mahasiswa dalam menggunakan elearning UIN Walisongo.
The Interdependence of Labour and Environmental Rights in South Africa
Authors: Hall J. , Van Staden M.
Published: July 2021

Labour and environmental rights in South Africa both originated in reaction to particular and important societal problems. Labour law has traditionally been concerned with inequalities of bargaining powers, whilst environmental law was historically concerned with protection of the biophysical environment. At first glance the two rights therefore appear to be unrelated. In view of arguments that fundamental human rights cannot be achieved in isolation. This article explores the potential relationship between the two rights. It begins by providing an overview of the intersection between labour and environmentalists during the struggle against Apartheid as a basis for identifying the priorities of both sectors in advocating for the two rights and how the divide between the two narrowed. That overview provides a backdrop for the discussion which follows regarding how the intersection between the rights has played out both within the traditional and expanded conceptualisations of labour law. The study finds that the two rights do have a dependence and that the environmental arena has provided the basis for the continuation of the fight to ensure social justice for both the traditional and extended reconceptualized approach to labour law.
Chief Editor’s Note on Collaboration and Research as the Key Contribution to the BRICS Environmental and Sustainable Development Agenda
Authors: Gladun E.
Published: July 2021

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Water Dimension of BRICS Cooperation: National Challenges and Joint Opportunities
Authors: Likhacheva A. , Kalachyhin H. , Abdolova S. , Kamenkovich N.
Published: July 2021

This article examines the evolution and potential of the water agenda of BRICS. The members of this international association of major countries of South America, Eurasia, Asia and Africa are rich in water resources and population. The development of water resources extends beyond their borders to projects in other countries through the activities of a major development institution, the New Development Bank of BRICS. Such conditions suggest some anticipation of a global and comprehensive view on the part of BRICS on the issues relating to water resources. However, the hypothesis of this article is opposite: despite the unique potential of the BRICS water strategy, it remains non-specific, focused on the lower common denominators for the member countries such as cleanliness, sanitation and water management. To account for this, the authors take the position that the bureaucratic logic of basic common interest downgrades strategic vision. This is reflected in the growing gap between the multifaceted nature of the issues related to water resources in the world and the narrowly specialized approach of BRICS association which perceives water de facto without its resource and global function. To study this, the authors analyze the water portfolios of the BRICS member countries and compare the national water agendas based on an analysis of policy documents. They then systematize water initiatives under the auspices of the BRICS and, finally, calculate virtual water flows and their structure between the BRICS countries using agricultural products trade as an example. The conducted analysis allows the authors to identify a wide gap between the current and potential water agenda of the BRICS. The authors then propose a number of initiatives that can create added value for the BRICS as an association both for its member countries and for developing countries facing water resource challenges. The authors assert that such a new approach, based on a profound understanding of the resource function of water as a commodity with global value, has all the potential to be implemented by BRICS.
Segurança jurídica no processo administrativo tributário: sobre a possibilidade de revisão judicial das decisões administrativas proferidas pelo Conselho Administrativo de Recursos Fiscais
Authors: Seixas Luiz Felipe Monteiro , Oliveira Larissa Fernandes de
Published: July 2021

Partindo da discussão em torno do princípio da segurança jurídica, este trabalho propõe-se a tecer considerações sobre o processo administrativo tributário federal e a possibilidade de revisão judicial de decisões proferidas pelo Conselho Administrativo de Recursos Fiscais. Para tanto, serão feitas considerações gerais sobre o processo administrativo fiscal, analisando a conjuntura do CARF antes e depois da Operação Zelotes. Em seguida, analisa-se a aplicação da segurança jurídica no processo administrativo tributário como uma garantia do contribuinte. Ao final, discute-se a possibilidade de revisão judicial das decisões administrativas, sejam elas favoráveis ao contribuinte ou ao Fisco, propondo-se critérios que justifiquem o ajuizamento de ação anulatória pela Fisco, nos casos de decisões que lhes forem desfavoráveis. Quanto à metodologia, foi utilizado método dedutivo e a pesquisa teórica (bibliográfica, documental e legislativa). Conclui-se que a possibilidade de questionamento judicial das decisões do CARF de forma ampla e irrestrita provoca insegurança no ordenamento jurídico brasileiro. No entanto, é possível estabelecer critérios específicos que autorizem à Fazenda Pública requerer a revisão judicial das decisões administrativas que lhe forem desfavoráveis, preservando-se a segurança jurídica necessária para o regular funcionamento do processo administrativo tributário.
Water quality assessment and geochemical processes in the unconfined coastal Boa Viagem Aquifer, Recife, NE Brazil
Authors: Silva Thyego , Lima Mariucha , Leitão Teresa , Martins Tiago , Albuquerque Mateus
Published: July 2021

A hydrochemical study was conducted on the Quaternary Aquifer, in Recife, Brazil. Groundwater samples were collected in March–April 2015, at the beginning of the rainy season. Conventional graphics, ionic ratios, saturation indices, GIS mapping, and geostatistical and multivariate statistical analyses were used to water quality assessment and to characterize the main hydrochemical processes controlling groundwater’s chemistry. Q-mode hierarchical cluster analysis separated the samples into three clusters and five sub-clusters according to their hydrochemical similarities and facies. Principal Component Analysis (PCA) was employed to the studied groundwater samples where a three-factor model explains 80% of the total variation within the dataset. The PCA results revealed the influence of seawater intrusion, water-rock interaction, and nitrate contamination. The physico-chemical parameters of ~30% groundwaters exceed the World Health Organization (WHO) guidelines for drinking water quality. Nitrate was found at a concentration >10 mg NO3−/L in ~21% of the wells and exceeded WHO reference values in one. The integrated approach indicates the occurrence of the main major hydrogeochemical processes occurring in the shallow marine to alluvial aquifer as follow: 1) progressive freshening of remaining paleo-seawater accompanying cation exchange on fine sediments, 2) water-rock interaction (i.e., dissolution of silicates), and 3) point and diffuse wastewater contamination, and sulfate dissolution. This study successfully highlights the use of classical geochemical methods, GIS techniques, and multivariate statistical analyses (hierarchical cluster and principal component analyses) as complementary tools to understand hydrogeochemical processes and their influence on groundwater quality status to management actions, which could be used in similar alluvial coastal aquifers.
Potential Eutrophication Associated with Phosphorus Inputs from Shrimp Effluents in a Tropical Estuary
Authors: Aquino Rafael , Rodrigues Susan , Souza-Filho Pedro , Kawakami Silvia
Published: July 2021

Shrimp farming has been associated with eutrophication due to the generation of effluents enriched with organic matter and nutrients. Phosphorus (P) distribution was investigated in the Coreaú River Estuary (NE Brazil) using surface sediments and sediment cores. In surface sediments, total P concentrations ranged from 349.2 to 633.5 μg g-1 (mean = 465.2) and were about three times lower than those of other Brazilian estuaries impacted by larger shrimp cultures. The predominance of P forms in surface sediments followed the sequence: iron-bound P (Fe-P, 30%) > organic-P (Org-P, 23%) > exchangeable-P (Exch-P, 20%) > authigenic apatite (Ca-P, 15%) > detrital apatite (De-P, 12%). No significant correlation was observed between Exch-P and Fe-P (r = 0.389; p < 0.05). Highest Exch-P and Org-P concentrations and a strong correlation between these forms were found (r = 0.706, p < 0.05), suggesting the same sources of P and organic matter. Total P accumulation along the cores was 10,211 and 15,632 μg g-1 at the estuary mouth (T1) and the upper estuary (T2), respectively. T1 exhibited the predominant sequence: De-P (36%) > Ca-P (25%) > Fe-P (22%) > Exch-P (9%) > Org-P (7%); whereas T2 showed: Fe-P (31%) > De-P (23%) > Org-P (21%) > Ca-P (17%) > Exch-P (9%). Phosphorus depositional history points to P accumulation episodes at the end of the 1980 and mid-1990, coinciding with increasing urbanization and the beginning or maximum activity of the shrimp farms. Despite the low total P concentrations, the proportions of the labile forms Exch-P, Fe-P and Org-P in surface sediments indicated a trend to a high potential for eutrophication.
METHODOLOGICAL INNOVATIONS IN THE RESEARCH OF PENTECOSTAL THEOLOGIANS IN THE NATIONAL PEDAGOGICAL DRAGOMANOV UNIVERSITY
Authors: CHORNOMORETS YURIY
Published: July 2021

Within the framework of cooperation of the National Pedagogical Dragomanov University with Protestant seminaries and their associations, more than ten defenses of dissertations on Pentecostalism took place. These defenses prove that Pentecostal theologians were able to overcome the closed nature of their own tradition to the development of theology. The ideological leadership of Protestant theology in Ukraine, especially Pentecostal theology, became possible due to the assimilation and development of the best methodological achievements of Western theology of the beginning of the 21st century. Ukrainian Pentecostal theologians actively use the methodology of theological hermeneutics, taking into account the achievements of post-liberal and post-conservative Western theology, modern biblical studies, mission theology and eschatology. The central point for the entire methodology was the recognition of the narrative character of the religious ideology. The analysis of narratives is complemented by the research of key narrative concepts, the research of the interaction of narrative theology and other post-metaphysical methodologies. The vision of the history of Christianity and the history of theology as processes characterized by periodic paradigm shifts allows us to conceptualize narratives and then create new narratives about these stories and about the prospects of both Christianity and theology. A particularly great achievement is the systematic presentation of the history of the Pentecostal movement as the history of communities that have special narratives, cultivate special virtues, and use special narrative concepts.
SOCIO-CULTURAL TRANSFORMATION IN POST-SOVIET UKRAINE
Authors: SKVORETS VOLODYMYR , KUDINOV IGOR
Published: July 2021

The relevance of the research problem is that the understanding of socio-cultural transformation allows us to identify social processes that affect the functioning of post-Soviet Ukrainian society. The research subject is the social processes that determine the content and nature of socio-cultural transformation of post-Soviet Ukrainian society. The purpose of the article is to comprehend the impact of socio-cultural changes on the functioning of post-Soviet Ukrainian society. The methodology of the socio-cultural transformation research is based on the use of systematic, logical, historical, dialectical and socio-cultural approaches and methods. The results of scientific research. In post-Soviet Ukraine, the general context of socio-cultural change is due to the implementation of market reforms that have led to privatization, deindustrialization, mass marginalization, transition to a liberal state and depopulation. These processes have led to socio-cultural changes in the lives of Ukrainian citizens. There were important changes in the social sphere, the social structure of the population, the distribution of national wealth, which changed the direction of its movement from the dominance of social development to the predominance of social degradation. There was a change in the social matrix of society’s reproduction: there was a transition from the dominance of the middle classes’ culture to the spread of the culture of the poor, the main feature of which is the struggle for survival. The essence of the socio-cultural transformation of post-Soviet Ukrainian society is the transition from the absolutism of the state to the absolutism of the market, which means the transformation of everything possible into a commodity, and the dominance of commodity-money relations in all spheres of public life. This transition was accompanied by a change in the historical and cultural type of human personality, commercialization, deprofessionalization, as well as the primitivization of public administration. Changes in the culture’s state have complicated the reproduction of society as a whole. The Soviet way of life has been dismantled, and the failure of the social matrix indicates that a new way of life in post-Soviet Ukraine has not yet been formed, and therefore socio-cultural transformation must be aimed at its formation. The practical value of the results lies in substantiating the content of socio-cultural transformation in post-Soviet Ukraine and its impact on the functioning of society.
Энергетический спектр и оптические свойства фуллерена C-=SUB=-80-=/SUB=-(I-=SUB=-h-=/SUB=-) в модели Хаббарда
Authors: Силантьев А.В.
Published: July 2021

The anticommutative Green’s functions were derived in an analytical form, and the energy spectra of С80 fullerene and endohedral Y3N@C80 fullerene of symmetry group Ih were obtained within the Hubbard model in the mean-field approximation. Using group theory methods, the classification of energy states was carried out, and the allowed transitions in the energy spectra of С80 and Y3N@C80 molecules of symmetry group Ih were determined.
Спектральное исследование протонирования фотохромных хроменов в полимерных матрицах
Authors: Венидиктова О.В. , Кобелева О.И. , Горелик A.М. , Барачевский В.А.
Published: July 2021

For the first time, proton complexes of the photoinduced colored form of chromene have been obtained in polymer binders. It is shown that UV irradiation of photochromic chromene leads to spectral changes due to the structure of the compounds and the nature of the polymer binder.
Совершенствование технологии изготовления рельефных голографических решеток на бихромированном желатине, облученных коротковолновым УФ излучением
Authors: Ганжерли Н.М. , Гуляев С.Н. , Маурер И.А.
Published: July 2021

Предложен новый вариант изготовления высокочастотных голографических решеток с пространственной частотой вплоть до 1500 mm-1 на слоях бихромированного желатина (БХЖ), из технологии обработки которого полностью исключены водные процедуры. Метод основан на применении ледяной уксусной кислоты после облучения слоев коротковолновым УФ излучением, в отличие от стандартной методики обработки зарегистрированных когерентным излучением He-Cd-лазера голографических структур. В ходе экспериментов получены рельефно-фазовые голографические решетки с дифракционной эффективностьюдо 41% при толщине слоя БХЖ 1.1 μm и до 64% при 5.6 μm. Ключевые слова: голографические дифракционные решетки, бихромированный желатин, коротковолновое УФ излучение, поверхностный рельеф, дифракционная эффективность, ледяная уксусная кислота, изопропанол.
Распространение предельно коротких оптических импульсов в массиве углеродных нанотрубок с полимерами под действием постоянного магнитного поля
Authors: Галкина Е.Н. , Белоненко М.Б.
Published: July 2021

Изучено воздействие постоянного магнитного поля на поведение предельно коротких оптических импульсов, распространяющихся в среде, состоящей из углеродных нанотрубок и полимеров. В качестве основного уравнения, описывающего распространение электромагнитного поля в рассматриваемой среде, выбрано уравнение Максвелла. Получены зависимости формы оптических импульсов от концентрации полимера в исследуемой среде. Ключевые слова: предельно короткий импульс, углеродные нанотрубки, магнитное поле, полимер.
Получение изолированных аттосекундных импульсов с большой электрической площадью в плотной резонансной среде
Authors: Архипов Р.М. , Архипов М.В. , Федоров C.В. , Розанов Н.Н.
Published: July 2021

Obtaining unipolar half-cycle optical pulses of femto- and attosecond duration with a large electrical area is an urgent but difficult task. The reason for the emerging difficulties lies in the existence of the rule of conservation of the electrical area of ​​the pulse, which does not allow converting a bipolar pulse into a unipolar one. In this work, it is shown that in a resonant medium a low-cycle pulse can be converted into two unipolar pulses separated in time by a distance that is an order of magnitude or more longer than the duration of the initial pulse. This allows in a number of problems to consider such pulses separately as unipolar. The estimation of the electric area value relative to its "atomic scale" is carried out.
Reach Outcomes and Costs of Different Physician Referral Strategies for a Weight Management Program Among Rural Primary Care Patients: Type 3 Hybrid Effectiveness-Implementation Trial
Authors: Porter Gwenndolyn , Michaud Tzeyu L , Schwab Robert J , Hill Jennie L , Estabrooks Paul A
Published: July 2021

Background

Rural residents are at high risk for obesity; however, little resources exist to address this disproportional burden of disease. Primary care may provide an opportunity to connect primary care patients with overweight and obesity to effective weight management programming.

Objective

The purpose of this study is to examine the utility of different physician referral and engagement processes for improving the reach of an evidence-based and technology-delivered weight management program with counseling support for rural primary care patients.

Methods

A total of 5 rural primary care physicians were randomly assigned a sequence of four referral strategies: point-of-care (POC) referral with active telephone follow-up (ATF); POC referral, no ATF; a population health registry–derived letter referral with ATF; and letter referral, no ATF. For registry-derived referrals, physicians screened a list of patients with BMI ≥25 and approved patients for participation to receive a personalized referral letter via mail.

Results

Out of a potential 991 referrals, 573 (57.8%) referrals were made over 16 weeks, and 98 (9.9%) patients were enrolled in the program (58/98, 59.2% female). Differences based on letter (485/991, 48.9%) versus POC (506/991, 51.1%) referrals were identified for completion (100% vs 7%; P<.001) and for proportion screened (36% vs 12%; P<.001) but not for proportion enrolled (12% vs 8%; P=.10). Patients receiving ATF were more likely to be screened (47% vs 7%; P<.001) and enrolled (15% vs 7%; P<.001) than those not receiving ATF. On the basis of the number of referrals made in each condition, we found variations in the proportion and number of enrollees (POC with ATF: 27/190, 50%; POC no ATF: 14/316, 41%; letter ATF: 30/199; 15.1%; letter no ATF: 27/286, 9.4%). Across all conditions, participants were representative of the racial and ethnic characteristics of the region (60% female, P=.15; 94% White individuals, P=.60; 94% non-Hispanic, P=.19). Recruitment costs totaled US $6192, and the overall recruitment cost per enrolled participant was US $63. Cost per enrolled participant ranged from POC with ATF (US $47), registry-derived letter without ATF (US $52), and POC without ATF (US $56) to registry-derived letter with ATF (US $91).

Conclusions

Letter referral with ATF appears to be the best option for enrolling a large number of patients in a digitally delivered weight management program; however, POC with ATF and letters without ATF yielded similar numbers at a lower cost. The best referral option is likely dependent on the best fit with clinical resources.

Trial Registration

ClinicalTrials.gov NCT03690557; http://clinicaltrials.gov/ct2/show/NCT03690557
Pengembangan Kinerja Mikroskop Binokular Menjadi Miskroskop Berkamera untuk Alat Praktikum dan Penelitian
Authors: Merlina Dita
Published: July 2021

Penelitian bertujuan memanfaatkan mikroskop binokular menjadi mikroskop berkamera sehingga mempermudah dalam proses pengamatan dalam kegiatan praktikum dan penelitian. Penelitian ini dilaksanakan dari bulan Oktober sampai dengan Desember 2020 di Laboratorium Lingkungan dan Budidaya Perairan Fakultas Perikanan dan Ilmu Kelautan Universitas Mulawarman Samarinda, Kalimantan Timur. Pendekatan penelitian yang dilakukan dalam yaitu perbandingan komparatif antara mikroskop binokular tanpa modifikasi dengan mikroskop binokular yang telah dimodifikasi dengan menambahkan kamera digital dengan analisis menggunakan deskriptif kualitatif. Mikroskop binokular dimodifikasi menjadi mikroskop digital yang dilengkapi fasilitas pemotretan sampel dengan menggunakan kamera digital. Sampel yang digunakan dalam pengamatan yaitu Plankton dari jenis air laut dan air tawar. Pengaturan secara teknis terdiri dari Pembesaran 100 Kali dan pencahayaan diagfragma berwarna putih pada setiap pengamatan. Hasil penelitian menunjukkan perbandingan antara penggunaan binokular tanpa kamera dan mikroskop berkamera hasil modifikasi, terdapat perbedaan warna dan pencahayaan dari berbagai jenis sampel plankton yang diamati. Mikroskop hasil modifikasi yang ditambahkan kamera digital  berdasarkan pengamatan berupa warna sel, bentuk sel, isi sel dan pencahayaan plankton lebih jelas dibandingkan dengan mikroskop binokular standar.
Uji Aktivitas Antibiofilm Minuman Sinbiotik Terhadap Staphylococcus aureus ATCC 2593
Authors: Muhammad Afivudien , Agustiningtyas Irena
Published: July 2021

Staphylococcus aureus merupakan salah satu bakteri yang bisa menyebabkan beragam penyakit dan punya kemampuan membentuk biofilm. Sehingga dapat melindungi diri dari antibiotik. Sinbiotik adalah suplemen makanan berbentuk minuman probiotik yang dapat menghambat pertumbuhan bakteri berpotensi patogen, salah satunya Staphylococcus aureus. Tujuan penelitian ini adalah untuk melakukan uji antibiofilm Sinbiotik terhadap Staphylococcus aureus. Penelitian ini merupakan penelitian eksperimental laboratorik dengan menggunakan sampel minuman sinbiotik G12, Biotoksi, dan Yakult. Sinbiotik diujikan pada biofilm Staphylococcus aureus yang sudah mendapatkan perlakuan yaitu dengan menumbuhkan bakteri daslam media Trypticase Soy Broth selama 24 jam pada suhu 37 ͦ C.Dalam penelitian ini analisa data yang digunakan adalan analilis univariat yaitu dengan melihat hasil rata-rata. Penghambatan biofilm yang terjadi diukur menggunakan penghitungan MBIC (Minimum Biofilm Inhibitory Concentration) dan antibiofilm menggunakan spektrofotometer untuk mendapatkan nilai OD. Sinbiotik G12 dan Biotoksi menunjukkan kemampuan antibiofilm terhadap Staphylococcus aureus masing-masing sebesar 70.17% dan 68.74%. Sedangkan hasil pada yakult sebesar 11.01% sehingga tidak mempunyai kemampuan antibiofilm.Dari hasil tersebut dapat simpulkan bahwa minuman sinbiotik G12 dan Biotoksi mempunyai kemampuan antibiofilm terhadap bakteri Staphylococcus aureus.
Analisis Manajemen Laboratorium Terpadu Mikroskopis Di Fakultas Kedokteran Universitas Cenderawasih Jayapura Papua (Studi Kasus)
Authors: Iswanto Dais , Mulyono Herlambang Budi
Published: July 2021

Keunggulan sebuah laboratorium pendidikan dapat direfleksikan dari kualitas dan profile  manajemen yang dijalankannya. Tujuan penelitian ini adalah untuk mengetahui sistem manajemen yang dijalankan di laboratorium terpadu mikroskopis Fakultas Kedokteran Universitas Cenderawasih (FK Uncen) Jayapura, Papua. Metode penelitian menggunakan pendekatan metode kualitatif dan deskriptive. Hasil penelitian menunjukkan bahwa implementasi manajemen laboratorium tergolong kurang maksimal dan sebagian saja yang berjalan sesuai kaidah manajemen secara baku. Hal ini dibuktikan dengan hasil pengukuran indikator perencanaan (planing) sebesar 51,72 % mengindikasikan positif atau kategori “Baik” dan sebanyak 41,37 % masuk dalam kategori “Kurang”. Sedangkan tiga komponen manajemen lainnya yang terdiri dari organizing, actuating dan controoling masing - masing indikator menunjukkan hasil sebesar 55,55 % masuk dalam kategori “Baik” dan 44,44% terbilang “Kurang”. Temuan dapat digunakan sebagai bahan kajian penting dalam institusi untuk memperbaiki sistem manajemen laboratorium secara bertahap dan berkelanjutan agar diperoleh fungsi manajemen laboratorium yang ideal sesuai aturan yang semestinya.
Optimasi Konsentrasi Primer dan Suhu Annealing dalam Mendeteksi Gen Leptin pada Sapi Peranakan Ongole (PO) Menggunakan Polymerase Chain Reaction (PCR)
Authors: Setyawati Retno , Zubaidah Siti
Published: July 2021

Polymerase Chain Reaction (PCR) adalah suatu teknik sintesis dan amplifikasi DNA secara in vitro. Teknik PCR dapat digunakan untuk mengamplifikasi segmen DNA dalam jumlah jutaan kali hanya dalam beberapa jam. Setiap gen mempunyai primer dengan konsentrasi dan suhu annealing yang berbeda, sehingga perlu dilakukan optimasi konsentrasi primer dan suhu annealing agar didapatkan komposisi dan kondisi PCR yang sesuai sehingga mendapatkan hasil PCR yang optimal. Tujuan penelitian ini adalah untuk mengetahui konsentrasi primer gen Leptin yang menghasilkan produk PCR dengan band yang optimal dan suhu annealing sampel DNA sapi Peranakan Ongole yang menghasilkan produk PCR dengan band yang optimal. Penelitian ini menggunakan sampel darah sapi yang mengandung gen Leptin dengan ukuran produk PCR 467 bp. Penelitian ini sudah dilakukan optimasi variasi penggunaan konsentrasi primer dan suhu annealing. Penelitian ini menggunakan variasi konsentrasi primer 5μM dan 10 μM yang berasal dari primer stok 100μM, sedangkan suhu annealing PCR yang digunakan yaitu 56oC, 58oC, 60oC, dan 62oC yang dihitung berdasarkan (Tm-5)oC, dari rata-rata primer forward dan reverse. Produk PCR kemudian di elektroforesis dan dicek hasilnya pada UV transiluminator. Gambar hasil elektroforesis kemudian dibandingkan secara visual. Hasil yang didapat dari penelitian ini yaitu produk PCR gen Leptin yang menghasilkan band yang optimal dihasilkan pada konsentrasi primer 10μM dan suhu annealing 58oC.
Challenges and Opportunities of English Grammar Acquisition by Distance at the Tertiary Level
Authors: Farneste Monta , Apse Vineta
Published: July 2021

Distance learning introduced in almost all educational establishments in spring 2020 has raised interest among researchers how to deal with it in a more productive way. Thus, the goal of the research was to find out undergraduates’ views on distance learning of English grammar and the use of online revision materials in developing students’ independent study skills at a tertiary institution in Latvia. the research tool was a questionnaire consisting of open-ended and closed questions. Twenty-three students answered the survey questions. the research results indicate that studying by distance is preferred because it allows the students to choose the study time and place, to develop their timemanagement, independent study skills, as well as improve their motivation. the main drawbacks of studying by distance, according to the students, are insufficient feedback, inability to ask questions directly and receive immediate answers and problems with their own time management and independent study skills.
Using the Methodology for the Comprehensive Assessment of Scientific and Technological Projects to Estimate Risks of their Failure
Authors: Komarov A. V. , Komarov K. A. , Shurtakov K. V.
Published: July 2021

The article proposes approaches to assessing the risk of non-implementation of scientific and technological projects, based on the analysis of data from institutions for innovative development of information, and carried out following the requirements of a comprehensive assessment of projects’ technological readiness. One of the approaches presented allows you to build a matrix for subsequent analysis that describes the possibility of a project oving to a higher level of development, and the second is based on identifying empirical dependencies between the level of readiness of the project being executed and the risk of violating its deadlines. Examples of applying  the developed approaches for practical tasks on program activities of target programs in the field of research and development in priority areas of the scientific and technological complex of Russia are given. The described models are intended for use in the governing bodies of innovative development institutions to increase the implemented support programs’ efficiency.
International Scientific Research on Venture Capital: a Bibliometric and Mapping Analysis from the Period 1978–2020
Authors: Lopez-Munoz F. , Eremchenko O. A. , Fernandez-Lopez M. A. , Rodriguez-Sanchez B. , Povedano-Montero F. J.
Published: July 2021

The aim of this study is to explore the relevance of scientific production on venture capital using bibliometric and mapping tools.

We performed a search in Scopus, involving any document published between 1978 and 2020. We used bibliometric indicators to explore documents production, dispersion, distribution, time of duplication, and annual growth, as Price’s law of scientific literature growth, Lotka’s law, the transient index, and the Bradford model. We also calculated the participation index of the different countries and institutions. Finally, we explored the co-occurrence and thematic networks for the most frequently used terms in venture capital research through bibliometric mapping.

A total of 1,230 original articles were collected from the timeframe 1978–2020. The model confirms that Price’s law is not fulfilled. Scientific production was better adjusted to linear growth (r = 0.9290) than exponential (r = 0.9161). Literature on venture capital research has increased its growth in the last 43 years at a rate of 7.9% per year, with a production that doubles its size every 9.1 years. The transience index was 79.91%, which indicates that most of the scientific production is due to a lot of authors with a small number of publications on the research topic. Bradford´s law shows that the scientific production in this area is widely distributed in multiple journals, and Lotka’s law indicates that the author’s distribution is heavily concentrated on small producers. The United States of America (USA) and the University of Pennsylvania present the highest production, contributing 31.22% and 1.63% of the total production of research on venture capital.

The venture capital task has undergone a linear growth, with a very high rate of transience, which indicates the presence of numerous authors who sporadically publish on this topic. No evidence of a saturation point was observed in the scientific production analyzed, which makes it possible to conclude that the research in venture capital will continue to be in demand by the scientific community.
A Conceptual Model for Assessing the Technological Readiness of a R&D Project and its Potential at the Early Stages of Development
Authors: Komarov A. V. , Pikhtar A. N. , Grinevsky I. V. , Komarov K. A. , Golitsyn L. V.
Published: July 2021

The article proposes a conceptual model for assessing the technological readiness and the potential of a R&D project at the early stages of its development (TPRA – Technology Project Readiness Assessment). The proposed model will allow to assess the technological readiness of the scientific and technological projects, the commercial potential of their results, the possibility of participation of the results of projects in the transfer of technologies, the possibility of using the results obtained as a scientific and technical groundwork, as well as the risks of nonfulfillment of projects within the framework of a single tool. The results that can be obtained in the assessment process can be used to improve the efficiency of planning and implementation of R&D in the institutions for innovative development, as well as in corporations and organizations that invest in R&D processes.
Subversões do gênero: Butler, Preciado, Lacan (Subversions of the genre: Butler, Preciado, Lacan)
Authors: Martin Clarice Arantes , Vieira Marcus André
Published: July 2021

Este artigo visa refletir sobre diferentes estratégias teóricas que cumprem o objetivo de desestabilizar a compreensão de gênero como algo fixo e estável, referido a um sistema binário. Ao abordar a teoria da sexuação de Lacan e alguns aspectos da teoria queer, buscamos corroborar com a ideia de que a tensão entre tais campos é extremamente fértil. Inicialmente, destacamos a noção de performance, de Butler, e a teoria do dildo, de Preciado: duas formas distintas de se pensar o gênero como modo aberto ao devir. Por fim, acrescentamos a contribuição lacaniana ao debate. Em nosso entender, a ênfase da teoria da sexuação é a sua referência ao gozo, como experiência singular do sexual no corpo, o que consequentemente descentraliza a noção de ser. Com isso, a teoria da sexuação se afasta do tema do gênero por visar capturar aquilo que extrapola os limites da atribuição de papéis sociais.
A trama fálica da insuficiência feminina e seus desdobramentos (The phallic plot of women's insufficiency and its developments)
Authors: Canosa Lindinaura
Published: July 2021

O presente artigo discute as operações discursivas sobre o feminino e os efeitos dessas operações sobre a criação de conceitos e consequentemente sobre as subjetividades. Tomando como principal ancoragem os textos de Freud tentaremos demonstrar como sua produção teórica foi afetada pelos ideais iluministas, isto é, influenciada por este momento particular da história do conhecimento, onde se operam mudanças radicais na história dos homens e de suas relações sociais e econômicas. Tomando particularmente a invenção de um novo conceito de mulher, tendo a maternidade como o modelo princeps como um processo indenizatório pela insuficiência, vergonha e ressentimento. E tendo como operador o referencial fálico na maior parte de sua obra.
Do dispositivo da sexualidade ao direito à diferença (From the device of sexuality to the right to difference)
Authors: Maciel Júnior Auterives
Published: July 2021

Ao analisar os dispositivos de sexualidade, as relações de saber e poder que eles incluem, o biopoder e as práticas de resistências derivadas de tais procedimentos normativos, Michel Foucault construiu uma ética das relações consigo, buscando uma explicação conceitual para a origem ou fonte das resistências encontradas na contrapartida das demais relações de sujeição. Todavia, na sua pesquisa histórica as relações consigo foram explicitadas nas análises empreendidas por ele no meio grego e romano; mas as condições efetivas de tais relações no mundo atual não foram descritas dado o falecimento prematuro do referido autor. Pois bem, neste texto buscamos as condições de possibilidade das relações consigo no mundo atual, para construirmos uma ética do direito à diferença, consolidando-a na contrapartida dos discursos identitários e coercitivos ditados pelos dispositivos de poder.
ENDOSCOPIC MANAGEMENT OF PIN STUCK INTO THE SEGMENTAL BRONCHUS
Authors: Kim Young Chul , Kwon Seong Keun
Published: July 2021

This case is a challenging case review of a successful removal of sharp
and deep located airway foreign body using ventilating bronchoscopy.
Adult insect personality in the wild -- Calopteryx splendens as a model for field studies
Authors: Gołąb Maria , Sniegula Szymon , Antoł Andrzej , Brodin Tomas
Published: July 2021

Animal personality has received increasing interest and acknowledgement
within ecological research over the past two decades. However, some
areas are still poorly studied and need to be developed. For instance,
field studies focused on invertebrates are currently highly
underrepresented in the literature. More studies including a wider
variety of traits measured and species tested is needed to improve our
understanding of trait-correlation patterns and generalities. We studied
nine behavioural traits, in the damselfly Calopteryx splendens, from an
array of three experiments: (i) courtship, (ii) aggressiveness and (iii)
boldness, and calculated their repeatability. The behaviours were
measured twice, in two different contexts: (i) undisturbed territory and
(ii) partially deteriorated territory. All behavioural traits measured,
except for two, were repeatable across the two contexts. This work
demonstrates, for the first time, the presence of within population
personality differences in an adult damselfly in the wild. We further
propose Calopteryx splendens as a promising model species for testing
personality in the wild under highly controlled environmental
conditions.
Statin-activation of RyR1 is a class effect but separable from HMG-CoA reductase inhibition
Authors: Lindsay Chris , Musgaard Maria , Russell Angela , Sitsapesan Rebecca
Published: July 2021

Background and purpose Statins, inhibitors of HMG-CoA reductase, are
mainstay treatment for hypercholesterolemia. However, muscle pain and
weakness prevent many patients from benefiting from their
cardioprotective effects. We previously demonstrated that simvastatin
activates skeletal ryanodine receptors (RyR1), an effect that could be
important in initiating myopathy. We therefore investigated if RyR1
activation is a standard property of commonly-prescribed statins. Using
a range of structurally-diverse statin analogues we examined structural
features associated with RyR1 activation, aiming to identify statins
lacking this property. Experimental Approach Compounds were screened for
RyR1 activity utilising [H]ryanodine binding.
Mechanistic insight into RyR1 activity was studied by incorporating RyR1
channels from sheep, mouse or rabbit skeletal muscle into bilayers. Key
Results All UK-prescribed statins activated RyR1 at nanomolar
concentrations. Cerivastatin, withdrawn from the market due to
life-threatening muscle-related side effects, was more effective than
currently-prescribed statins and possessed the unique ability to open
RyR1 channels independently of cytosolic Ca. We
synthesised the statin pharmacophore and it did not activate RyR1. We
also identified five analogues retaining potent HMG-CoA reductase
inhibition that inhibited RyR1 and four analogues that lacked the
ability to activate RyR1. Conclusion and Implications That cervistatin
activates RyR1 most strongly supports the hypothesis that RyR1
activation is implicated in statin-induced myopathy. Demonstrating that
statin-regulation of RyR1 and HMG-CoA reductase are separable effects
allows the role of RyR1 in statin-induced myopathy to be further
elucidated by the tool compounds identified, thus paving the way for the
development of effective cardioprotective statins with improved patient
tolerance.
Electrocardiographic and Electrophysiological Characteristics of Idiopathic Ventricular Arrhythmias Ablated Through a Percutaneous Trans-pericardial Approach
Authors: Ju Weizhu , zhang jinlin , Shi Linsheng , Gu Kai , Chu Ming , Chen Hongwu , Yang Gang , Li Mingfang , Liu Hailei , Zhang Fengxiang , YANG Bing , Chen Minglong
Published: July 2021

Aims Idiopathic epicardial ventricular arrhythmias (VAs) are clustered
in the areas of the summit and crux. This study was to report a group of
idiopathic epicardial VAs remote from the summit and crux areas. Methods
In total, 9 patients (6 males, mean age 32±13 years) were enrolled. The
locations were identified by epicardial mapping and ablation. The
electrocardiographic and electrophysiological characteristics were
compared to those of 9 patients who had VAs ablated at the opposite
endocardial site. Results VAs were identified at the epicardium, with 4
patients had VAs located at the inferior wall, one at the anterior wall,
one at the apex and 3 patients had VAs at the lateral wall. A “QS”
type at the location-related leads was the only identified surface
electrocardiogram indication suggesting epicardial origin (compared to
that of the controls, 100% vs 0%, p<0.001). Endocardial and
epicardial mapping revealed pre-maturities of -11±4 ms and -25±8 ms,
respectively (VS. -28±8 ms revealed by endocardial mapping in control
patients, p<0.001 and p=0.389, respectively). All of the study
cases demonstrated an “rS” pattern in the endocardial unipolar
electrogram. Acute and long-term successful ablation (a median of 11
months of follow-up) was achieved in all patients without complications.
Conclusion A distinct group of idiopathic VAs remote from the summit and
crux areas warranting ablation by a subxiphoid approach were identified.
Morphological ECG features of a “QS” type among the location-related
grouped leads combined with the mapping findings helped in the
identification of the epicardial site of origin.