bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of of Montilukaste with or without Desloratidin in treatment of Bronchial Asthma
Authors: Shareef Abdulla Mohammad
Published: September 2023

The role of leukotriens antagonist alone and with the new generation H1 antihistaminics is not well elucidated. This study has been designed to evaluate the role of montilukast with and without desloratidine in the treatment of mild to moderate severity bronchial asthma. This is a double blind placebo control clinical trial which has been conducted on 150 patients with mild to moderate bronchial asthma in the period between July 2011 to January 2012 in Tikrit General Hospital and Private Clinic. The patients were divided into 3 groups, first group received montilukast alone, the second group received montilukast plus desloratidine and the third group received placebo tablet. Forced expiratory volume in first second (FEV1), Peak expiratory flow rate (PEFR), and Asthmatic Symptom Score were measured before and after the treatment period of three months. There was a significant improvements in all parameters in the montilukast group (P≤ 0.01). The combination of montilukast with desloratidIne resulted in a highly significant improvement in all parameters (P≤ 0.001). From this study we conclude that montilukast is a useful drug in the armamentarium against asthma, however the addition of desloratidine appears to have synergistic action in patients with mild to moderate bronchial asthma
Appearance of F-wave during electrophysiological study of
Authors: E. Sulaiman Mohammed
Published: September 2023

To evaluate the appearance of F-wave in patients with carpal tunnel syndrome through electrophysiological study. Fifty patients with carpal tunnel syndrome(CTS) of the median nerve who were diagnosed clinically and through electrophysiological study for median and ulnar nerve. Fifty normal subjects of healthy volunteers of similar age and gender were compared to the patients and examined for nerve conduction study. Nerve conduction study for median and ulnar nerve (motor and sensory) were done for each patient and subject in neurophysiology department to study the distal motor and sensory latency (DML,DSL), compound motor and sensory action potentials (CMAP,SNAP) ,motor and sensory nerve conduction velocities (MNCV,SNCV) and F-wave latencies(maximum, mean and minimum). There are prolonged distal motor and sensory latency, decrease of compound motor and sensory action potential, decrease of motor and sensory nerve conduction velocity and prolongation of F-wave latencies( minimum, mean and maximum.) of the median nerve (motor) in carpal tunnel syndrome patients compared with the controls and these differences are statistically significant p-value < 0.01. The F-wave parameters for median nerve must be added in electrophysiological study to establish the diagnosis of carpal tunnel syndrome.
Assessment of Liver Enzymes Activity in Patients with Rheumatoid Arthritis in Nineveh province
Authors: R. Tawfeeq Hiba
Published: September 2023

Aim of the study: to determine the effect of Rheumatoid Arthritis(RA) on liver enzymes level. Methods: 75 subjects were enrolled in this study (40 patients with Rheumatoid arthritis (RA) and 35 healthy subjects as control group), at Mosul city, Northern of Iraq, aged 20-70 years. The biochemical parameters measured were some of liver function tests which include measurement of the liver enzymes activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT). Results: There was a significant increase in liver enzymes activity in patients when compared to control. There was also significant increase in serum AST level at age group 40-50 years when compared to other age group in patients, in addition, there was a significant increase in serum ALP in female patients when compared to male patients. There was non-significant change in liver enzymes activity when compared according to residence, according to family history, and according to rheumatoid factor in patients. Conclusion: The results of the present study indicated no deterioration in liver functions in patients with rheumatoid arthritis regarding serum enzymes (aspartate transaminase, alanin transaminase, gamma glutamyl transferase and alkaline phosphatase), although subclinical alteration in liver functions could be expected in those patients, so that measurement of other early markers of liver dysfunction is occasionally recommended.
Herbal Treatment, Usage Frequency, Types and Preferences in Tikrit city, Iraq
Authors: Abdulkhalk Yehea Al-Handh Ban
Published: September 2023

Alternative treatment usage is increasing around the world although treatment methods are becoming more modern and more drugs are made available. A cross sectional study was conducted to determine the incidence of treatment with herbs as an alternative treatment method in Tikrit city and the reasons for its usage. in a sample (number =1268) in the age group (20 – 50) years. duration of the study extended from the January 1, 2011 to December 31, 2011. In Tikrit there were 15 herbal stores ,and 35 pharmacies deal with herbal treatment such as nettle, St. John’s wort, rosemary, garden sage and hawthorn, oleander and thyme. The study was carried out with a questionnaire to persons who had received preliminary information. After the subjects were informed of the study, the analysis of medicinal plants by the participants. Nine hundred sexist two(75.9%) of those participating in the study reported that they had used a herbal medication at least once. The main health problems leading to the usage of herbal medication for their treatment was hair loss - hair care, hemorrhoids, skin care, peptic ulcer - gastritis and infertility. The main reason for interest in herbal treatments was “hoping to find a herbal medicine which could help treat their condition”. People living in Tikrit city has a high rate of alternative medicine usage and regular studies are required to show changes over time.
Role of Misoprostol in Induction of Labor: Sublingual versus Vaginal in Tikrit City
Authors: Tahir Saihood Sumaya
Published: September 2023

A successful induction of labor leads to vaginal delivery of a healthy baby, in an acceptable time frame with minimum maternal discomfort or side effects. To compare the efficacy and safety of sublingual and per vaginal 25µg misoprostol for labor induction. Primary outcome measures were the number of cases delivering vaginally, Secondary requirement, the incidence of meconium-stained liquor, number of cesarean deliveries, the incidence of hyperstimulation/tachysystole, maternal adverse effects and neonatal outcomes. A prospective study was conducted in Tikrit Teaching Hospital. Indications were reviewed; 416 women randomly received misoprostol 25 µg vaginally and sublingually every three hourly for maximum three doses. Outcomes were analyzed accordingly. The number of the cases who successfully delivered vaginally was greater in the sublingual group. The induction to vaginal delivery interval was significantly shorter in sublingual group. The incidence of tachysystole and meconium-stained liquor were more in the vaginal than in the sublingual group. The mean doses, mode of delivery, oxytocin augmentation and maternal outcomes were significantly favorable in sublingual group. No significant difference is seen in neonatal outcome. Sublingual misoprostol 25 µg administered three hourly for labor induction has better effficacy as compared to 25 µg of vaginal misoprostol.
The Value of Ultrasound in Diagnosing Acute Appendicitis
Authors: Mushref Abdulsalam Baha'a
Published: September 2023

Acute appendicitis considered one of the causes of acute abdomen. The diagnosis is usually straight forward in typical cases, but this is not true in atypical cases. This study is to assess the value of ultrasound modality in diagnosing acute appendicitis. From January 2009 to January 2012 in Al-Ramadi teaching hospital, 196 patients were included in this study, 10 patients were excluded, and 186 examined by ultrasound, after adequate clinical assessment, for their signs and symptoms that suggestive of acute appendicitis. Age groups were 6-75 years, Mean age 33.5 years, with 105(54%) males, and 91(46%) females. 186 patients could be explained, and examined by ultrasound, with mean age of 33.5 years, the diagnosis had established in 34 patients. The false positive was three cases, and false negative was six cases, this means that the ultrasound had failed in these nine cases. The sensitivity is 81.8%, the specificity is 98%. 90% and 96.2% are the positive and negative predictive values respectively. The diagnostic accuracy is 95.5%. The P-value is
The Role of Endothelin-1 and Oxidative Stress In Pregnancy Induced Hypertension
Authors: A.H. Jasim Shaimaa
Published: September 2023

Pregnancy Induced HypertensionPIH is one of the most frequent complications of pregnancy , however little is known about its etiology. Endothelial dysfunction serves as a causative factor in the initiation of the maternal pathophysiological changes of PIH & is not just a result of this disorder. Endothelin-1 may play an important role in the pathophysiology of PIH, either by acting on vascular smooth muscle directly to induce contraction or by increasing the formation of angiotensin II. Pregnancy induced hypertension is associated with endothelial dysfunction & could be caused by oxidative stress. Recent evidence suggest the role of oxidative stress in PIH. The high level of malondiahyde MDA may reflect the excessive oxidative damage in PIH. The study sample consist of 50 normal non pregnant women, 50 normotensive pregnant women, and 50 preeclamptic pregnant women in their third trimester in Mosul city. The aim of this study was designed to evaluate the role of endothelial dysfunction and oxidative stress in pathogenesis of PIH. The results of this study showed that there was a highly significant elevation (P0.000) in the serum level of endothelin-1 in the preeclamptic pregnant women in comparison with normotensive pregnant & the control group. Also there was a highly significant elevation (P0.000) in the level of serum MDA in the preeclamptic pregnant women in comparison with normotensive pregnancy & the control group. The serum endothelin-1 has a significant negative correlation with both maternal age & gestational age, while endothelin-1 has a significant positive correlation with diastolic blood pressure. The MDA showed a significant negative correlation with maternal age, while there was a significant positive correlation between MDA & diastolic blood pressure.
A Rare Presentation of Self-Resolving Purple Fingers
Authors: Schwartz Chelsea , Watson Raj , Cleaver David
Published: September 2023

Achenbach syndrome is a rare, benign, self-limiting, syndrome of unknown etiology. Here, we report a 66-year-old female who presented to the dermatology clinic with waxing and waning non-palpable purpura for the last year on the volar aspect of her hands bilaterally. The patient admitted to tingling prior to the onset of the purpura and mild tenderness following presentation. The purpura would spontaneously resolve without discoloration or scarring after 2-7 days. The patient stated these episodes can occur anywhere from a few times a month to every 1-2 months. Evaluation and work-up performed by her primary care physician and rheumatologist did not reveal an explanation for her symptoms. Two punch biopsies were performed and revealed a perivascular lymphocytic infiltrate with extravasted erythrocytes and pigmented macrophages consistent with a pigmented purpuric dermatosis. Immunofluorescence was negative. The diagnosis of Achenbach syndrome was made by diagnosis of exclusion. Reassurance was provided to the patient and she was given DerMend Bruise formula cream, which contains retinol, glycolic acid, arnica oil, ceramides, niacinamide, and phytonadione, to monitor for improvement of her symptoms. It is important for healthcare providers to be aware of the benign nature of this syndrome to be able to provide reassurance to patients and avoid an unnecessary, more invasive evaluation.
Coinciding Erythema Nodosum and Sweet’s Syndrome Without an Apparent Secondary Cause
Authors: Ramesh Malvika , Ramesh Pranav , Hope Richard
Published: September 2023

Erythema Nodosum and Sweet’s Syndrome are both inflammatory dermatoses with similar causes and treatments. They usually occur independent of each other and when they occur together, a secondary cause such as malignancy or infection may be responsible. We present a patient with both Erythema Nodosum and Sweet’s Syndrome who lacked any secondary cause making this presentation quite uncommon.
Evolving Pink Papule in a Young Female
Authors: Tannenbaum Rachel , Yan Bernice , Shah Pooja
Published: September 2023

Eccrine porocarcinoma (EPC) is a rare cutaneous adnexal tumor derived from sweat glands. Typically, EPC presents as a nonspecific erythematous papule or nodule most commonly on the head, neck, or lower extremities of females in the sixth or seventh decade of life. This tumor may arise from an existing benign eccrine poroma or occur de novo. Herein, we report a case of a growing erythematous nodule with overlying telangiectasia on the lower extremity of a woman in her twenties. Biopsy revealed a cyst-like lesion beneath the epidermis comprised of clear fluid material. Both solid and cystic components were present alongside pleomorphic tumor cell aggregates characterized by mitotic figures, hyperchromasia, and necrosis. The combination of clinical presentation and the presence of ductal structures on histopathologic analysis led to a diagnosis of EPC. This case reinforces the critical importance of histopathologic analysis of a nonspecific lesion that has evolved over time and may resemble other forms of cutaneous malignancy.
Erosive Pustular Dermatosis of the Scalp Treated with Serial Debridement: Case Report
Authors: Douthitt Brenna , Luu Lydia , Flowers Richard
Published: September 2023

An 82-year-old man with a past medical history of numerous non-melanoma skin cancers (NMSCs), including unresectable squamous cell carcinoma of the right temple treated with radiation therapy and cemiplimab, presented with worsening erosive pustular dermatosis of the scalp (EPDS). This had initially onset four years prior in the setting of 5-fluorouracil and photodynamic therapy for actinic keratoses. He had failed topical ultra-potent steroids, tacrolimus, and dapsone as well as oral dapsone, doxycycline, and acitretin. The condition’s chronicity and radiation to the area likely exacerbated his EPDS. We pursued serial debridement, followed by clobetasol propionate 0.05% ointment twice daily. The patient reported marked improvement with stable condition between treatments. Upon better control of his EPDS, a suspicious ulcerative lesion under a previously affected area was identified and biopsied, revealing atypical fibroxanthoma. EPDS is an inflammatory dermatosis characterized by pustules, erosions, and crusting, often caused by sun damage, local trauma, and topical medications. First-line treatment is topical corticosteroids. We show that serial debridement is effective for treating recalcitrant EPDS. We emphasize the importance of maintaining adequate control of EPDS to avoid masking suspicious lesions, as the patient demographic affected by EPDS is at high risk for NMSCs.
Development of Psoriasis During Treatment with Weekly Dupilumab for Refractory Hailey-Hailey Disease
Authors: Ragmanauskaite Laura , McEwen Matthew , Jones Emily , Tirado Mariantonieta , Jones Allison
Published: September 2023

Hailey-Hailey Disease is a rare inherited disease that is often to treat. Several case reports have discussed the potential role of dupilumab for the treatment of Hailey-Hailey Disease. Our case presents a patient who required more frequent dosing of dupilumab than previously reported to manage his symptoms. His course was further complicated by development of psoriatic lesions which were successfully treated with topicals steroids, allowing continuation of dupilumab.
Profile of Patients with Alcohol Dependence admitted to a Drug De-addiction Center in a Tertiary Care Hospital
Authors: Dutta Atreyee , Nayek Sandipan , Deka Bikashita
Published: September 2023

Objective

To examine the profile of patients admitted to a drug de-addiction center of a tertiary care center or hospital with alcohol dependence.

Material and Methods

The study was held in the Department of Psychiatry, Assam Medical College and Hospital, Dibrugarh, Assam during the period from August 2020 to September 2021. 120 patients who fulfilled the criteria for alcohol dependence according to ICD-10 were included. Alcohol Use Disorder Identification Test (AUDIT) and Michigan Alcoholism Screening Test (MAST) were applied.

Results

Around 13.3% of the study participants started drinking alcohol at the age of 15 years. The average age at which the patients initiated drinking alcohol was 24.02 ± 7.19 years, and patients who had started drinking at an early age became dependent within 15 years of regular drinking. The most common cause of initiation of drinking was found to be curiosity, peer pressure, and familial disharmony (68.8%). Most of the patients (80%) were from the lower socio-economic class, educated till middle school, and majority (80.9%) of the participants had an AUDIT score of >20 indicating alcohol dependence.

Conclusion

Alcohol use is seen to begin at a young age (about 15 years), primarily in individuals with less education and in rural communities of this region of the state. Hence, public awareness campaigns and school-based educational initiatives should be undertaken.
A case of temporary occlusion of donor artery after secondary generalized seizure in a patient with superficial temporal artery-middle cerebral artery bypass
Authors: Tsukada Tsuyoshi , Masuoka Toru , Kubo Michiya
Published: September 2023

Background:

To prevent stroke recurrence, a superficial temporal artery-middle cerebral artery (STA–MCA) bypass for atherosclerotic cerebrovascular occlusive disease is performed. Post stroke epilepsy is known as serious sequelae of stroke. Herein, we present a case of a 60-year-old man who underwent STA–MCA bypass for the prevention of stroke recurrence; however, the donor artery was deemed to be temporally occluded secondary to generalized seizure.

Case Description:

A 60-year-old man was referred to our hospital with a diagnosis of the left cervical internal carotid artery occlusion presenting with mild aphasia and right hemiparesis. He underwent STA–MCA bypass to prevent the recurrence of stroke 1 month after the onset of symptoms. On postoperative day 7, patency of the donor artery was confirmed on magnetic resonance imaging (MRI), and no complications were noted. However, on postoperative day 14, he presented with a secondary generalized seizure. MRI was immediately performed and the donor artery was not patent with no new lesions. Several hours thereafter, the blood flow of the donor artery was confirmed using pulse Doppler; however, during mouth opening, the flow of the donor artery decreased. Computed tomography-angiography confirmed donor artery patency. An encephalogram was conducted and revealed a focal epilepsy which was compatible with stroke on MRI.

Conclusion:

Post stroke epilepsy caused an unintended and forced mouth opening which led to a temporary occlusion of the donor artery after STA–MCA bypass. Thus, this complication should be recognized, and seizures should be prevented through the administration of prophylactic anti-seizure medication based on risk stratification assessment of post stroke epilepsy.
LIPID PEROXIDATION IN INDIVIDUALS WITH POST-CORONAVIRUS SYNDROME
Authors: Румянцев Е.К. , Николаев В.М. , Софронова С.И. , Григорьева А.А. , Чирикова Н.К.
Published: September 2023

Наши результаты свидетельствуют о том, что с увеличением степени тяжести течения заболевания COVID-19, увеличивается количество жалоб на повышения артериального давления. Интенсивность свободнорадикального окисления липидов даже через 8 месяцев с момента выписки из стационара была выше у переболевших с более тяжелым поражением легких.

Our results suggest that as the severity of the COVID-19 disease progresses, the number of complaints of increased blood pressure increases. The intensity of free radical lipid oxidation, even after 8 months from the moment of discharge from the hospital, was higher in those who had recovered from the disease with more severe lung damage.
THE POSSIBILITY OF USING HYDROGELS IN HYDROMETALLURGY FOR THE EXTRACTION OF HEAVY METALS (BRIEF REVIEW)
Authors: Очеретяна С.О.
Published: September 2023

Гидрогели имеют множество полезных свойств и широко используются в различных промышленных отраслях, включая медицину, сельское хозяйство и косметологию. Однако, их адсорбционные свойства делают их особенно привлекательными в гидрометаллургии, где их способность извлекать тяжелые металлы и другие загрязняющие вещества может быть полезной для защиты окружающей среды и извлечения ценных ресурсов из отвалов. Существует два основных типа гидрогелей: синтетические и природные. Природные гидрогели, такие как агар или желатин и карбоксиметилцеллюлоза, считаются менее вредными для окружающей среды и более биоразлагаемыми. Однако, синтетические гидрогели имеют более высокую устойчивость к механическому износу и могут иметь более высокую адсорбционную способность. Анализ литературных данных показывает, что на данный момент гидрогели и их модификации привлекают значительный интерес, особенно в области извлечения тяжелых металлов. Ниже приведен краткий обзор некоторых работ и аспектов, связанных с этой областью.

Hydrogels have many useful properties and are widely used in various industries, including medicine, agriculture and cosmetology. However, their adsorption properties make them especially attractive in hydrometallurgy, where their ability to remove heavy metals and other contaminants can be beneficial to protect the environment and recover valuable resources from dumps. There are two main types of hydrogels: synthetic and natural. Natural hydrogels such as agar or gelatin and carboxymethylcellulose are considered less environmentally harmful and more biodegradable. However, synthetic hydrogels have higher resistance to mechanical wear and may have higher adsorption capacity. An analysis of the literature data shows that hydrogels and their modifications are currently attracting considerable interest, especially in the field of heavy metal extraction. Below is a brief overview of some of the work and aspects related to this area.
STUDY OF ALIPHATIC HYDROCARBONS IN THE THERMOHYDROLYSIS PRODUCTS OF SAPROPELITE AND BROWN COALSBY CHROMATO-MASS SPECTROMETRY
Authors: Рокосов Ю.В. , Рокосова Н.Н. , Горюнова П.В.
Published: September 2023

С помощью метода хромато-масс-спектрометрии, с учетом закономерностей фрагментации соединений при ионизации электронным ударом, проведено сравнительное исследование состава алифатических углеводородов ближнего диапазона распределения (< n-C18) в продуктах термогидролиза сапропелитов Кушмурунского месторождения Казахстана, бурых углей Кайчакского месторождения (Кемеровская область) и Кангаласского месторождения (Якутия). Проведен сравнительный анализ данных о групповом и индивидуальном составе алифатических углеводородных фракций. Индивидуальные алифатические соединения и их гомологи идентифицировали по масс-спектрам с использованием базы данных NIST-11 и информационно-поисковых программ AMDIS и ChemStation.

Using the method of gas chromatography-mass spectrometry, taking into account the patterns of fragmentation of compounds during ionization by electron impact, a comparative study of the composition of aliphatic hydrocarbons in the near distribution range (< n-C18) in the products of thermal hydrolysis of sapropelites from the Kushm-urunsky deposit in Kazakhstan, brown coals from the Kaichaksky deposit (Kemerovo region) was carried out and the Kangalassky field (Yakutia). A comparative analysis of data on the group and individual composition of aliphatic hydrocarbon fractions has been carried out. Individual aliphatic compounds and their homologues were identified by mass spectra using the NIST-11 database and AMDIS and ChemStation information retrieval programs.
Structural Tuning of β-Enamino Diketones: Exploration of Solution and Crystalline State Photochromism
Authors: B. Manjappa Kiran , Yang Ding Yah , Fan Sheng-Chieh
Published: September 2023

A library of -enamino diketones was prepared via base-mediated, three-component reaction of 4-hydroxycoumarins with various aromatic/aliphatic amines and β-nitrostyrenes under microwave irradiation conditions to investigate their photochemical properties. Among the prepared compounds, a thiophene derived β-enamino diketone was found to be light-sensitive and to exhibit unique photochromic behavior, that is, positive photochromism in solution and negative photochromism in crystalline phase. In addition, this prepared photochromic compound was further covalently linked to a structure-related, piezochromic β-enamino diketone moiety to explore its potential multi-stimuli responsive properties.
Integration of Computational and Experimental Techniques for the Discovery of SARS-CoV-2 PLpro Covalent Inhibitors
Authors: Ying Huang Ho , Pinus Sharon , Zhang Xiao Cong , Wang Guanyu , Rueda Andrés M , Souaibou Yaouba , Huck Solène , Huot Mitchell , Vlaho Danielle , Pottel Joshua , Venegas Felipe , Lu Zhuoqun , Hennecker Christopher , Stille Julia , Tjutrins Jevgenijs , Miron Caitlin , Labarre Anne , Plescia Jessica , Burai-Patrascu Mihai , Mittermaier Anthony , Moitessier Nicolas
Published: September 2023

Papain-like protease (PLpro) and 3-chymotrypsin-like protease (3CLpro or Mpro) are enzymes essential for the replication of SARS-CoV-2, the virus responsible for COVID-19. While 3CLpro has been the main target of many potential antivirals including nirmatrelvir (active ingredient of Paxlovid), PLpro has proven to be more difficult to target and only a handful of inhibitors have been disclosed. PLpro inhibitors would be highly valuable tools in the fight against COVID19 resistant strains and in future coronavirus pandemics. Combining our experience with 3CLpro covalent inhibitors with our expertise in structure-based covalent drug discovery, we rationally designed PLpro inhibitors achieving a maximum potency of 13 µM through fusion of GRL-0617 and VIR-251. In parallel, we launched an integrated large scale virtual screening/experimental approach, identifying four novel chemical series active at micromolar concentrations against PLpro. We report herein our investigations including rational design, virtual screening, synthesis of selected structures and in vitro assays leading to novel PLpro inhibitors.
Inhalation of climbing shoe particles is highly relevant for the human exposure to rubber-derived chemicals in indoor facilities
Authors: Sherman Anya , Masset Thibault , Wimmer Lukas , Dailey Lea Ann , Hüffer Thorsten , Breider Florian , Hofmann Thilo
Published: September 2023

There is increasing research focused on rubber-derived chemicals (RDCs), predominantly originating from tire and road wear particles. Other consumer products also contain RDCs, but the overall human exposure to these compounds is unknown. This study investigated climbing shoes as a potential contributor to human indoor exposure to RDCs, including potentially harmful substances such as benzothiazoles, p-phenylenediamines (PPDs), and PPD-quinones. The soles of climbing shoes contain high but variable concentrations of RDCs (mean 711 μg/g). In indoor climbing halls, abrasion particles from these shoes can be suspended in the air. Dust and air samples were collected in two climbing halls and particulate matter in the inhalable and respirable fractions were analyzed for 15 RDCs. Concentrations in dust (16 to 43 µg/g) and particulate matter (23 to 35 ng/m3) exceed those reported from other environments. For most RDCs, estimated daily intake via inhalation (EDIinh) for adults visiting or working in these facilities exceeds the EDI from other sources. This highlights the potential concerns with using large amounts of rubber additives in consumer products. RDCs profiles in shoe samples differed from those in dust and particulate matter, indicating that RDCs are chemically transformed in airborne rubber particles. This finding has broader implications as similar transformations are likely to occur in airborne tire wear particles.
Isolation and structure determination of new neolignans and cabagranin D, an unusual meroterpenoid from Piper cabagranum
Authors: de Oliveira Jr. Celso , Ledvina Zachary D. , Leonard Michael D. , Odoh Samuel , Dodson Craig D. , Jeffrey Christopher S.
Published: September 2023

A novel meroterpenoid cabagranin D was isolated along with related neolignans cabagranins A-C from the leaves of Piper cabagranum (Costa Rica). Cabagranins A-C represent the first examples of 3,3’-neolignans isolated from the Piper genus of plant and the meroterpenoid cabagranin D, representing an unprecedented Diels-Alder conjugate of an unsubstituted phenylpropenone and alpha-phellandrene. Details of the full structural elucidation of these compounds and a discussion of the potential biosynthetic relationships are presented.
Experiential Pathways to Infusing Spirituality in Pre- Service Art Education
Authors: Campbell Laurel , Dalton Jane E. , Simmons III Seymour
Published: September 2023

This paper addresses diverse approaches to researching spirituality in art education. It then argues for the importance of such research today, given current controversies related to religion, and the general divisiveness that increasingly imperils public education along with other aspects of society. As we assert, addressing spirituality through art can help connect students rather than divide them, enabling them to find common ground through learning about art and through the experiences of making it. Each of these issues will be discussed in considering the following research agendas: definitions of spirituality, contemplative practice, and relations between spiritual traditions, East and West.
RESEARCH OF HISTORICAL PREREQUISITES AND RETROSPECTIVE FEATURES OF THE EVOLUTION OF INDIVIDUAL MACROECONOMIC THEORIES AND MODELS OF ECONOMIC GROWTH
Authors: Матризаев Б.Д.
Published: September 2023

Сегодня неоспоримым является тот факт, что инновации стимулируют современный экономический рост. Соответственно, как у всякого экономического феномена, возникает необходимость переосмысления того, каковы были исторические предпосылки и ретроспективные особенности начала эволюции эндогенной макроэкономической теории экономического роста. Целью статьи является исследование природы противоречий и характера взаимовлияния экзогенной и эндогенной макроэкономических теорий экономического роста; роли обобщающих и разделяющих факторов, вызывающих зарождение и развитие отдельных макроэкономических теоретических направлений. Научную новизну статьи представляет предложенный автором новый критический взгляд на исследование исторических предпосылок и ретроспективных особенностей эволюции отдельных макроэкономических теорий и моделей экономического роста, в особенности модели эндогенного роста, чтобы показать, что природа инноваций сама по себе имеет неоднозначную оценку со стороны макроэкономической науки.

Today, it is indisputable that innovations stimulate modern economic growth, respectively, as with any economic phenomenon, there is a need to rethink what were the historical prerequisites and retrospective features of the beginning of the evolution of the endogenous macroeconomic theory of economic growth. What was the nature of the contradictions and the nature of the mutual influence of exogenous and endogenous macroeconomic theories of economic growth, the role of generalizing and separating factors that cause the emergence and development of individual macroeconomic theoretical directions? In this article, the author offers a new critical look at the study of historical prerequisites and retrospective features of the evolution of individual macroeconomic theories and models of economic growth, especially the endogenous growth model, in order to show that the nature of innovation itself has an ambiguous assessment by macroeconomic science. Keywords: macroeconomic theory, economic growth, innovative dynamics, methodology, model, endogenous growth, exogenous growth. About the author:
RARE WOODY PLANTS IN PRIMORSKY KRAI (RUSSIAN FEDERATION)
Authors: Коляда А.С. , Берсенева С.А. , Белов А.Н. , Репш Н.В.
Published: September 2023

Из более чем 300 видов древесных растений, произрастающих в Приморском крае, 70 видов являются редкими, то есть встречаются в незначительном количестве, часто занимая узколокальный ареал. 16 видов являются эндемиками Дальнего Востока и Приморского края, остальные – произрастают на границе своего более обширного ареала, либо являются ушедшими из культуры. По числу родов (12) и видов (17) преобладает семейство Rosaceae, большая часть семейств представлена 1-2 родами и 1-4 видами. Наиболее крупным родом является Thymus L., представленный 7 редкими видами. Редкие древесные растения Приморского края имеют все основные жизненные формы, среди которых преобладают кустарники (28 видов). Большая часть видов (38) встречается в южной части региона и занимает преимущественно лесные местообитания. Возможно включение в Красную книгу Приморского края в статусе EN (угрожаемый вид) – Alangium platanifolium (Siebold et Zucc.) Harms; в статусе VU (уязвимый вид) – Cotoneaster nedoluzhkoi Tzvelev, Dasiphora davurica (Nestl.) Kom. и D. gorovoii Pshenn., Lonicera boczkarnikovae Plekhanova, Fraxinus stenopterus Urussov, Quercus aliena Blume, Pinus funebris Kom., Acer microsieboldianum Nakai, Rubus pungens Cambess. ex Jacq., Ephedra distachya L., E. sinica Stapf; в статусе LR (низкая степень риска) – Quercus wutaishanica Mayr, Empetrum sibiricum V. Vassil., Dryas ajanensis (Juz.) Hulten, Sieversia pentapetala (L.) Greene, Spiraea beauverdiana C. K. Schneid., Betula exilis L.

Among more than 300 species of woody plants growing in Primorsky Krai, at least 70 species are rare, i.e. found in small numbers, often occupying a strictly local area. Of these, 16 species are endemic to the Far East and Primorsky Krai, the rest grow on the border of their larger range or escaped from culture. The family Rosaceae are the richest by the number of genera (12) and species (17), most of the families are represented by 1-2 genera and 1-4 species. The largest genus is Thymus, which includes 7 rare species. Rare woody plants of Primorsky Krai have all the main life forms, among which shrubs (28 species) predominate. Most of the species (38) are found in the southern part of the region and occupy mainly forest habitats. It is possible to include in the Red Book of Primorsky Krai in the status of EN (threatened species) – Alangium platanifolium; in VU status (vulnerable species) – Cotoneaster nedoluzhkoi, Dasiphora flava and D. gorovoii, Lonicera boczkarnikovae, Fraxinus stenopterus, Quercus aliena, Pinus funebris, Acer micro-sieboldianum, Rubus pungens, Ephedra distachya, E. sinica; in LR status (low risk) – Quercus wutaishanica, Empetrum sibiricum, Dryas ajanensis, Sieversia pentapetala, Spiraea beauverdiana, Betula exilis.
MATERIALS TO THE RED DATA BOOK OF THE TVER REGION FOR THE YEAR OF 2022
Authors: Гарин Э.В. , Рыбакова А.А. , Рыбаков В.А. , Марков М.В. , Митрофанова Л.П. , Ведерникова О.П. , Матершев И.В. , Куропаткин В.В. , Корягина Е.С. , Иванов Д.Г. , Подолян Е.А.
Published: September 2023

Приведены полевые данные 2022 года о новых находках и проверке ранее известных местонахождений редких и уязвимых видов флоры и фауны, в том числе занесенных в Красную книгу Тверской области. Материалы собраны в рамках работ по подготовке нового, третьего, издания Красной книги Тверской области.

The field data for year of 2022 on new finds and verification of previously known localities of rare and vulnerable species of flora and fauna, including those listed in the Red Data Book of the Tver Region are presented. The data was obtained of the course of preparation of the third edition of the Red Data Book of the Tver Region.
Evaluating the effect of natural, industrial juices and beverage on orthodontic bonding composite (in-vitro study)
Authors: Ahmed Rusal S , Saleem Alan I
Published: September 2023

Background: Dental erosion is a common oral condition which results due to consumption of high caloric and low pH acidic food such as carbonated drinks and fruit juices. It is expected that these food types can cause irreversible damage to dental hard tissues and early deterioration of the dental restorations. So, this study aimed to evaluate and compare the erosive potential effects of orange fruit juice and Miranda orange drink on the microhardness of an orthodontic composite material. Materials and methods: Thirty discs with a thickness of 2 mm and a diameter of 10 mm were prepared from orthodontic bonding composite. The prepared discs were equally divided into three groups (n=10). Microhardness analysis was carried out both prior to and subsequent to immersion cycles. The microhardness of the specimens underwent evaluation subsequent to immersion in the beverages for durations of 6 hours (equivalent to one day) and 42 hours (equivalent to seven days). Microhardness measurements at baseline, one day, and one week were performed utilizing the Vickers microhardness testing. Statistical analyses were carried out using repeated measure one way ANOVA test and Bonferroni post-hoc test with a level of significant p< 0.05. Results: The micro hardness of composite exposed to the selected soft drinks was significantly decreased (p< 0.05). Conclusions: Natural, industrial orange juices and Miranda can affect the micro hardness of composite. The beverage effect on the orthodontic composite based on the type of juice and the exposure time to these beverages.
Financial results of a budgetary institution as the subject of a forensic economic examination
Authors: Ivankov V.M.
Published: September 2023

The article is devoted to the study of the financial results of budgetary institutions when they become the subject of forensic economic examination under the trial of cases of embezzlement and misappropriation of public funds and property. The author described accounting processes and sub-processes based on the decompositional division of the process of forming the financial result in budgetary organizations into two stages. The latter are the foundation of the subject of forensic economic examination of the financial result. As revealed, the first stage covers the processes of closing sub-accounts of income and expenses for exchange and non-exchange transactions. The sub-processes of accounting reflection of income and expenses are identified, which determine the final values of the balance of the corresponding accounts. The processes of the second stage of reflecting the financial results of a budgetary institution in the forms of financial statements are determined. It is proposed to highlight the points of expert study of the financial result, corresponding to the algorithms for its development in accounting. As concluded, it is expedient to use such a sequence of expert research of the financial result of a budgetary institution that meets the algorithms for its accounting formation and reflection in financial statements. It is proved that the construction of an expert study in a way that does not reproduce the sequence of formation of the financial result on the accounts can lead to incorrect conclusions, distortion of the assessment of the income-expense ratio in the forms of financial statements. The usefulness and practical application of such a subject of forensic economic expertise lies in the possibility of its adaptation to changes in the norms of the current legislation. Adaptation is proposed to be carried out by clarifying the processes and sub-processes of accounting for the formation of financial results via the identification of points of expert study, and in the case of expanding the tasks of examination with other indicators, for example, the financial condition of a budgetary institution, their addition and expansion.
НИЗЬКОТЕМПЕРАТУРНІ ПРОЦЕСИ ОДЕРЖАННЯ БОРВУГЛЕЦЕВИХ КОМПОЗИЦІЙНИХ МАТЕРІАЛІВ
Authors: Скачков Віктор Олексійович , Бережна Ольга Русланівна , Карпенко Ганна Володимирівна , Варченко Дмитро Анатолійович
Published: September 2023

Викладено підхід за способом отримання гідридів бору та визначення константи швидкості розкладання діборану в проточному термохімічному реакторі ізобарного типу за умов осадження твердого осаду як кристалічного бору на поверхні вуглецевих волокон. Термохімічний реактор ізобарного типу забезпечує контрольовані умови реакції шляхом підтримки постійного тиску усередині реактора. Це дозволяє стабілізувати режим реакції та забезпечити однорідну розподілення реагентів у системі. Методика визначення константи швидкості розкладання діборану базується на аналізі дина- міки формування кристалічного бору на поверхні вуглецевих волокон. За допомогою експериментів і математичного моделювання встановлюються залежності між умовами реакції, швидкістю розкладання діборану та осадженням кристалічного бору. Отримані результати дозволяють оптимізувати процес отримання гідридів бору шляхом регулю- вання умов реакції та вибору оптимальних параметрів реактора. Це може призвести до покращення якості гідридів бору, забезпечуючи більш високу чистоту та однорідність продукту. Осадження кристалічного бору на поверхні вуглецевих волокон допомагає уникнути домішок та забруднень, що можуть вплинути на властивості гідридів бору. Крім того, використання проточного термохімічного реактора ізобарного типу дозволяє забезпечити стабільні умови реакції, що сприяє однорідному формуванню продукту. Запропонований підхід для отримання гідридів бору та визначення константи швид- кості розкладання діборану в проточному термохімічному реакторі ізобарного типу з осадженням кристалічного бору на поверхні вуглецевих волокон відкриває перспек- тиви для поліпшення якості цих матеріалів та розвитку їхнього використання у різних галузях науки й технологій.
ПРОЦЕС КОРОЗІЇ МІДНО-НІКЕЛЕВОГО СПЛАВУ В ТРУБКАХ КОНДЕНСАТОРІВ ДРУГОГО КОНТУРУ АЕС
Authors: Воденнікова Оксана Сергіївна , Воденнікова Ольга Сергіївна , Рагалевич Альона Олександрівна
Published: September 2023

На сьогодні в умовах АЕС актуальною залишається проблема створення та підтримки фізико-хімічних властивостей теплоносіїв, які б запобігали корозійним пошкодження конструкційних матеріалів обладнання та утворення відкладень на його поверхнях. Актуальність роботи полягає в тому, що при виборі коригувальної добавки, що є найменш агресивною по відношенню до мідьвмісних сплавів, вдасться уникнути виносу міді з регенеративного тракту низького тиску і осідання її на трубках парогенератора, а, отже, знизити ймовірність виникнення контакту корозії з наступним руйнуванням стін парогенератора. В роботі проведена оцінка впливу корегувальних добавок – морфоліну (C4H9NO), етаноламіну (C2H7NO) та аміаку (NH3)) на процес корозії мідно-нікелевого сплаву типу МНЖ‑5–1, що використовується в трубках конденсаторів другого контуру ВП ЗАЕС. Лабораторні дослідження процесу корозії сплаву МНЖ‑5-1 проводили за наступних умов: при кімнатній температурі (22 °С), наявності кисню та без підтримки величини водневого показнику (рН); при відсутності кисню, температурі розчину 80–90 °С та підтримці величини рН. Так за умов кімнатної температури, наявності кисню та без підтримки величини рН швидкість корозії зразків при витримці в розчині аміаку в 2,3 рази більше, ніж при витримці в морфоліні. За умов відсутності кисню, температурі розчину 80–90 °С та підтримці величини рН швидкість корозії зразків при витримці в розчині аміаку в 1,3 рази більше, ніж при витримці в морфоліні. Встановлено, що найбільш агресивною коригувальною добавкою по відношенню до мідьвмісних сплавів є аміак, а найменшою – морфолін. Це зумовлює доцільність застосовувати морфоліновий або етаноламіновий режими в умовах ВП ЗАЕС з великою кількістю обладнання з мідьвмісними сплавами у другому контурі. Застосування морфолінового та етаноламінового водно-хімічних режимів призводить до зниження концентрації заліза у поживній воді у 2–3 рази та підвищення рН у паро-водяному контурі.
ТЕХНОЛОГІЯ ВИГОТОВЛЕННЯ ЛИВАРНИХ МОДЕЛЕЙ З ВИКОРИСТАННЯМ ВІДХОДІВ ДЕРЕВООБРОБНОГО ВИРОБНИЦТВА
Authors: Воденнікова Оксана Сергіївна , Скідін Ігор Едуардович , Воденнікова Лариса Володимирівна
Published: September 2023

Запропонована схема технологічного циклу виготовлення ливарних моделей з відходів деревообробного виробництва (тирси). Як майстер-модель використовується вже існуюче модельне оснащення. По майстер-моделі виготовляється промислова модель (форма), яка заповнюється методом ущільнення з навантаженням 2 МПа модельною сумішшю. Модельна суміш складається з відходів деревообробного виробництва та матеріалів, що пов’язують – смоли марки БС‑40, рідкого скла та гіпсу марки Г‑10. Застосування моделей з відходів деревообробного виробництва в порівнянні з традиційними (дерев’яною, металевою, пластиковою моделями) має ряд істотних переваг: виготовлення модельних комплектів у найкоротші терміни з мінімальними витратами на механічну обробку та без використання додаткового обладнання; нижча вартість порівняно з металевим оснащенням; висока зносостійкість, що не поступається пластиковим моделям; висока ремонтопридатність; точність, стабільність розмірів та конфігурації моделі протягом тривалого терміну служби; мінімальне зусилля знімання при формуванні, завдяки унікальним протиадгезійним властивостям за рахунок суміші для просочення, практично виключає необхідність використання розділових покриттів як при формуванні піщано-глинистих сумішей, так і при виготовленні форм та стрижнів сумішей; можливість тиражувати по одній майстер-моделі необмежену кількість моделей з абсолютно точним відтворенням еталона. Проаналізовано вплив виду та кількості матеріалу, що пов’язує, на фізико-механічні властивості моделей. Показано, що застосування смоли та тирси у співвідношенні 1,25:1 дозволяє збільшити міцність на стискання до 30 кгс/см2 та межу міцності на стискання до 0,0153 кгс/см2. Це обумовлено тим, що в результаті використання смоли, утворюється більш міцний каркас моделі, що майже не поступається характеристикам міцності деревині (сосні). Розглянуто вплив гранулометричного складу компонентів модельної суміші – рідке скло та тирса у співвідношенні 2:1 на фізико-механічні властивості готових моделей. Показало, що збільшення фракції суміші рідке скло та тирса з 0,25 до 2 мм збільшує межу міцності на стискання в 3 рази.