bluuebunny/crossref_metadata_2025 huggingface dataset:
A study on delayed cord clamping and early skin-to-skin contact and its effects on neonatal outcome
Authors: Nee Laxmi Sharma Laxmi Dixit , Gayadin Yadav Sushilkumar , Sangeeta Kansal  , Sinha Shuchi Jain , Jain Madhu
Published: January 2024

Background: Previous study conducted against immediate tying and cutting of the umbilical cord and suggested waiting until the child had taken repeated breaths and the pulsation in the cord had ceased to prevent potential weakness in the child.  A comparative study between delayed cord clamping (DCC) and early cord clamping (ECC) was carried out on a select group of primigravida without any high-risk factor and delivering at term. The objective of the study was to identify the effects of delayed cord clamping and early skin to skin contact on new born infant’s physiological parameters (temperature, weight, SpO2= saturation of peripheral oxygen, Apgar score= appearance, pulse, grimace, activity, and respiration, Hb=haemoglobin level).
Methods: Study sample consisted of 300 mothers and their new born after gaining mother’s acceptance. They were divided into 2 groups of 150 each. Group A underwent delayed cord clamping and early skin to skin contact and group B early cord clamping. Newborns monitored 24 hours for hypothermia, apnoea, oxygen needs.
Results: The findings of the present study were equivalent among both groups regards the mean neonatal haematological parameters were comparable and slightly elevated hemoglobin level and weight status among late cord clamping compared to early cord clamping group with significant difference was observed at 24 hour later.
Conclusions: This study was found that DCC does have a beneficial effect on temperature, Apgar score, SpO2, Hb level and weight status of new born. Therefore, it is believed that DCC and early skin to skin contact (ESSC) provides effective thermal control with a reduced risk of hypothermia.
Evaluation of ovarian mass in reproductive age group: a 2 years prospective study in a tertiary care hospital in Haryana
Authors: Mahur Beena , Kaur Satwant , Gulia Manish , Sehrawat Sheetal
Published: January 2024

Background: In pre-eclampsia, there is increased uteroplacental resistance and reduced fetal perfusion due to inadequate invasion of spiral arterioles by trophoblast cells. This causes impaired fetal growth and fetal hypoxia. The objective was to assess the usefulness of fetal Doppler in predicting adverse perinatal outcome in preeclampsia.
Methods: It was a prospective study conducted in Adesh medical college and hospital, Mohri, KKR, Haryana, India during the period of 2 years (2021-2022) on 92 women of reproductive age group from menarche to menopause, attending the hospital with complaints of lower abdomen pain, flatulence, lump in abdomen, changes in urinary and bowel habits and ovarian mass detected on clinical examination, or on ultrasound done for another reason. All details were filled in predesigned Performa.
Results: There was a great deal of variation in the occurrence, behaviour, and clinical presentation of ovarian tumors. In addition to physical examination, laboratory investigations such as immunological testing and serum biomarkers and imaging procedures pelvic ultrasonography), can assist to determine the kind of pathology. The diagnosis of non-neoplastic and neoplastic ovarian lesions can be confused due to similar clinical presentations. Ovarian cancers have one of the worst prognoses of any cancer since there is insufficient screening to identify the disease early.
Conclusions: It is imperative to raise awareness of this malignancy among Indian women. Because of the diversity of the Indian population, it is necessary to raise awareness of this issue across all linguistic and cultural divides. Not only should early detection be emphasized, but also “how to live well” with the illness should be discussed. All of these sophisticated, more recent diagnostic methods, along with the clinical and histo-morphological factors, can aid in early diagnosis, treatment planning, and prognostic importance.
A clinical study on ectopic pregnancy in a tertiary care hospital over one year
Authors: Khandkar Sharvari A. , Modi Rahi , Jain Mahima
Published: January 2024

Background: Ectopic pregnancy is a life threatening emergency in obstetrics presenting in the 1st trimester. The incidence is about 1% globally. We have aimed to study the incidence, presentation and management of ectopic pregnancy. Various risk factors were identified which may be helpful in reducing maternal mortality.
Methods: A one year retrospective study involving detailed medical records of patients who underwent obstetric hysterectomy between 1st November 2022 and 31st October 2023.
Results: The overall incidence of ectopic pregnancy was 0.8% in this study. The incidence was highest in 26-30 year age group (40%) followed by 21-25 year age group (36.4%). 95.2% cases presented with tubal ectopic while 2.4% each of cervical ectopic and caesarean scar ectopic pregnancies. LSCS was the most common risk factor associated with ectopic pregnancy, other risk factors included pelvic inflammatory disease in 33.3% cases, 29.5% patients with infertility treatment. 59% were ruptured ectopic pregnancies, 40% with unruptured ectopic pregnancy and 1% case of chronic ectopic. Multiple signs were seen in majority of patients including tachycardia, hypotension, abdominal tenderness, guarding and rigidity, vaginal forniceal fullness and tenderness. Management included laparotomy (58.8%), laparoscopy (31.7%), dilatation and evacuation (3.5%), medical management (3.5%) and hysterectomy (2.3%). No case of maternal mortality was noted.
Conclusions: Ectopic pregnancy is still a major challenge in obstetrical practice because of its bizarre clinical presentation. Maternal outcome depends upon timely diagnosis and urgent management of such patients.
Correlation of serum vitamin D level with various aspects of polycystic ovarian syndrome
Authors: Meena Mahendra , Panda Soumya Ranjan
Published: January 2024

Background: Women with PCOS usually suffer from metabolic disturbances and IR, which might be associated with vitamin D metabolism. The objectives of this study are to determine the association of Vitamin-D with metabolic and endocrine parameters in PCOS women and to evaluate specific role of Vitamin-D in PCOS and to correlate the serum Vitamin-D level with various demographic, anthropometric, biochemical, metabolic and hormonal parameters in PCOS patient.
Methods: This case control study was carried out between July 2014 and June 2016 in the Department of Obstetrics and Gynaecology, IMS, BHU got ethical clearance from the institute. The study involved 192 patients with polycystic ovarian syndrome based on Rotterdam criteria and 200 healthy age matched women as controls. The data analysis was performed with the help of SPSS 16.0 version for windows.
Results: When study subjects are compared according to vitamin-D level (sufficiency, insufficiency and deficiency) there was significant difference for BMI (kg/m2), Waist Hip ratio and TRG (mg/dl). Vitamin-D had significant negative correlation with BMI (p=0.000); Waist:Hip ratio (p=0.012); Triglyceride (p=0.022).
Conclusions: Our study found an association between the high prevalence of obesity and metabolic dysfunction in women with PCOS, and vitamin-D deficiency could be secondary to obesity in such patients. Thus, vitamin-D deficiency cannot be considered as an independent factor through the development of metabolic disorders in PCOS patients.
Endometrioid adenofibroma of ovary-a two faced tumour: case report
Authors: Lucksom Pesona G. , Kharka Latha V. , Lepcha Hissay , Rao Sohan
Published: January 2024

Endometrioid variant of the adenofibromas accounts for only 1% of epithelial neoplasms of ovary. Though benign, specimen of endometroid adenofibroma of ovary needs to be evaluated by an experienced pathologist to rule out borderline and malignant cases. This prevents unnecessary adjuvant therapy for benign cases. We report a case of a large endometrioid adenofibroma arising at the left ovarian fossa in a post-menopausal woman who had undergone total abdominal hysterectomy with bilateral salpingo-oophorectomy 6 years back. Recurrence of endometroid adenofibroma of ovary is rare, however, long term follow-up is mandatory due to its low malignant potential. Though benign, specimen of endometroid adenofibroma of ovary needs to be evaluated by an experienced pathologist so that borderline and malignancy can be ruled out. Endometroid adenofibroma of ovary though benign needs long term follow up due to its low malignant potential.
A comprehensive review of mucinous ovarian cancer: insights into epidemiology, risk factors, histological characteristics, and clinical outcomes
Authors: Gupta Sumedha , Kalwaniya Dheer Singh , Shamsunder Saritha
Published: January 2024

Mucinous ovarian cancer (MOC) represents a rare subtype within the spectrum of epithelial ovarian carcinoma (EOC). In contrast to a uniform approach applied to all EOC subtypes, MOC stands out as a distinctive entity. A nuanced understanding of the pathological features and genomic profile of MOC holds the potential for enhancing management strategies and, consequently, prognostic outcomes. The differentiation between primary MOC and metastatic mucinous carcinoma poses a challenge but is imperative for accurate clinical decision-making. Notably, early-stage MOC exhibits a favourable prognosis, while advanced disease is characterized by a less favourable outcome. Surgical intervention assumes a pivotal role both in the early stages and metastatic scenarios. Chemotherapy is typically initiated from stage II MOC onwards, with the conventional gynaecological protocol commonly employed; however, there is also precedent for the application of gastrointestinal (GI) regimens. Given the association of MOC with diverse molecular alterations, the consideration of targeted therapy emerges as a potential therapeutic avenue for this unique disease entity. The main tool used for this literature review was PubMed. MOC stands as a distinct entity within EOC subtypes, distinguished from GI mucinous carcinoma by its unique clinical behavior, pathological features, molecular profile, prognosis, and response to standard treatment. The challenges lie in both the diagnosis and treatment of MOC, emphasizing the complexity and specialized considerations required for managing this particular subtype of OC.
Unforeseen effects of COVID-19 on reproductive hormones and health of Indian women
Authors: Sharma Sheela , Afaq Nashra
Published: January 2024

Numerous systematic probes, clinical studies and research papers have been published to depict, interpret, explain and understand the impacts and underlying mechanism of the coronavirus disease 2019 (COVID-19) pandemic and its long-term effects on the female body. COVID-19 affects a number of organs, including the female reproductive function and hormonal profile. However, less attention has been given to the effects of COVID-19 on the female reproductive system due to their low morbidity. The available results of studies involving correlation that COVID-19 infection and ovarian function holds in women of reproductive age has been shown as harmless in most cases. Although, several studies have reported the involvement of COVID-19 infection in oocyte quality, ovarian function, and dysfunctions in the uterine endometrium and the menstrual cycle. The findings of these studies indicate that COVID-19 infection negatively affects the follicular microenvironment and dysregulate ovarian function. Although the COVID-19 pandemic and female reproductive health have been studied in humans and other animals, very few studies have examined how COVID-19 affects the female reproductive system. Our objective in this review is to enumerate, illustrate and categorize the effects of COVID-19 on the female reproductive system, including the ovaries, uterus, and hormonal profiles. We tried to bring forth the possible impact COVID-19 may have caused from the current literature and surveys published in various scientific reports and peer reviewed journal articles. The effects on oocyte maturation, oxidative stress, which causes chromosomal instability and apoptosis in ovaries, in vitro fertilization cycle, high-quality embryos, premature ovarian insufficiency, ovarian vein thrombosis, hypercoagulable state, women’s menstrual cycle, the hypothalamus-pituitary-ovary axis, and sex hormones, including estrogen, progesterone, and the anti- Müllerian hormone, are circled around here. The COVID-19 pandemic has significantly impacted the health of women. The scientific community encourages the development of recommendations for specialized care for women and strategies to prevent and respond to violence during and after the COVID-19 pandemic.
Accurate delta hedging of european options using conformable calculus
Authors:   Universidad Iberoamericana, Ciudad de México, Olmos Andrés , Muriel Nelson ,   Universidad Iberoamericana, Ciudad de México
Published: January 2024

Objective: we aim to develop a method for delta hedging portfolios of European options based on the theory of conformable calculus which improves accuracy of risk management of listed options in a first-order approximation. Methodology: we allow the time derivative in the classic Black-Scholes-Merton model to have a fractional order0 ≤α≤ 1 and calculate the corresponding delta of a portfolio of listed options as a function of this conformableparameter. Results: applying this method to a portfolio consisting of eight European options on the SPX index, we find that conformable delta hedging offers more accurate average predictions than classical delta hedging. Limitations: this method is applicable for delta hedging in European options only. Originality: this is the first successful application of conformable calculus to delta hedging in European options. Conclusions: application of Conformable Calculus allows for a greater flexibility in the local approximation to price in delta-hedging European options and offers a new and more precise methodology to this objective.
La Ley 11/2019 de Cooperativas de Euskadi y sus referentes para el perfeccionamiento de la regulación de la cooperativa en Cuba
Authors: Rodríguez Musa Orestes , Hernández Aguilar Orisel
Published: January 2024

Los particulares vínculos de proximidad que han existido entre la experiencia jurídica vasca en materia de cooperativas y la cubana sustentan la pertinencia de examinar la posible repercusión de la Ley 11/2019 «De Cooperativas en Euskadi» en la isla. La exposición que sigue comienza explicando la perspectiva que se asume respecto a los estudios de comparación jurídica, haciendo énfasis en su presencia y necesidad en sede de Derecho Cooperativo. A continuación, se procede a analizar por separado distintos aspectos contenidos en la Ley 11/2019 «De Cooperativas de Euskadi» que por su carácter avanzado y/o novedoso revisten interés para el cooperativismo cubano, argumentando los espacios y la necesidad de acoger los progresos que introduce la referida disposición vascuence.Recibido: 02 junio 2023Aceptado: 20 noviembre 2023
La política y la construcción del Poder Político Cooperativo como factor de incidencia y competitividad
Authors: Yorg José Alberto , Ramírez Zarza Ana María
Published: January 2024

Este trabajo pretende aportar elementos sustanciosos para la reflexión y discusión en ámbitos de interés. Aborda una temática poco o nada tratada en esferas del cooperativismo, en congresos o encuentros, en especial en la educación cooperativa, cual es el tema de la política en las cooperativas y la construcción del poder político cooperativo, entendida ésta como categoría de la ciencia política, no como política-partidaria. El abordaje temático discute la necesidad de incentivar la conciliación entre la ciencia política y el cooperativismo, como campos del saber y accionar complementarios en bien del pueblo. Abordamos desde un punto de vista político: La construcción del poder político cooperativo como factor de incidencia y de competitividad en el mercado y ante los gobiernos.Recibido: 07 julio 2023Aceptado: 30 noviembre 2023
Las normas laborales frente al COVID-19 en el trabajo a distancia: un análisis en el periodo del 2020 al 2022
Authors: Teatino Mendoza Natividad , Alvites Huamaní Cleofé Genoveva
Published: January 2024

El presente artículo tiene por objetivo dar alcance si la normativa laboral regulaba el trabajo remoto y dentro de este se encuentra el trabajo a distancia, como una modalidad contractual, para hacer frente en el contexto de la pandemia denominada COVID-19, toda vez que esta sorprendió no solo al sistema salud sino también en la prestación laboral, la misma que se venía realizando de manera presencial, y ante esta situación a nivel mundial en aras de preservar la vida, se declaró el estado de emergencia y la inamovilidad de toda la población, quedando de forma excepcional ciertas actividades que por su propia naturaleza, no podían realizarse a distancia.Recibido: 20 julio 2023Aceptado: 20 noviembre 2023
The Legal Nature of Forced Redemption of Property for State Needs as a Form of Legitimate Limitation of the Legal Capacity
Authors:   Head of the Department of Civil Law and Procedure of the Ural Institute of Management (Branch) of the Russian Presidential Academy of National Economy and Public Administration, PhD (Law), Associate Professor, Chelysheva Natalia Yu.
Published: January 2024

The article provides a detailed analysis of the legal nature of compulsory purchase of property for state and municipal needs as a form of lawful restriction of legal capacity. The author focuses on the analysis of the fundamental concepts and principles underlying this phenomenon. The specific features of applying the mechanism of state coercion to a private owner for the purpose of satisfying public interests are considered. Positions of foreign and international judicial bodies and researchers recognizing the fact of restriction of legal capacity of individuals and legal entities in case of forced termination of their property rights in the interests of the state are presented.
Molecular Docking Interaction of Medicines Binding to COVID-19 Proteins
Authors: IBRAHİM Ammar , SULLIMAN Entesar , IBRAHIM Maher A
Published: January 2024

In late 2019, in Wuhan, China, a new human coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first appeared. This virus caused the respiratory ailment known as coronavirus disease 2019 (COVID-19), which spread quickly throughout the world. Researchers from all over the world are working feverishly to comprehend SARS-CoV-2 and explore the pathophysiology of this illness to identify viable therapeutic drug candidates and treatments. This research is part of our ongoing search for an effective antiviral medication to combat this devastating illness, which necessitates work in medicinal chemistry. Every day, a sizable number of people die from the terrible disease COVID-19. This research looked at using docking theoretical calculations for dealing with the docking between medicines with proteins. Nine compounds of medicines named Aminoglutethimide, 4-aminosalicylic acid, Felbamate, Hydroflu-methiazide, Methazolamide, Modafinil, Nepafenac, Oxcarbazepine and Trichlormethiazide are used that are commonly active groups like amino group, hydroxyl, and ketone in their conformation structures. Two inhibitions of proteins in the SARS-CoV-2 virus (COVID-19) are applied (6xbg and 6xfn) for docking with nine medicines depending on the software of the Molecular operating environment package (MOE). The docking score was found to be that trichlormethiazide had a more stable value (-6.2955) and (-6.5462) with (6xbg) and (6xfn) proteins respectively.
Kadrovski management in tehnologija veriženja blokov
Authors: Urh Marko , Jereb Eva
Published: January 2024

Prispevek obravnava možnosti uporabe tehnologije veriženja blokov na področju kadrovskega managementa. Tehnologija veriženja blokov ima številne prednosti, ki lahko v določenih primerih nadomestijo ali obogatijo obstoječe rešitve v kadrovskem managementu, ki jih sedaj ponujajo klasične baze podatkov. Glavne lastnosti omenjene tehnologije so sledljivost, preglednost, varnost, hitrost, stroškovna učinkovitost, decentralizacija, avtomatizacija in drugo. Zaradi številnih pozitivnih lastnosti se omenjena tehnologija uporablja na vedno več področjih, med katerimi prevladujejo finančna in avtomobilska industrija, oskrbovalne verige, zavarovalništvo in drugo. Kadrovski management je eno izmed področij, kjer tehnologija veriženja blokov ponuja drugačne rešitve za aktualne probleme. V prispevku so dodatno pojasnjene priložnosti uporabe tehnologije veriženja blokov v kadrovskem managementu s poudarkom na plačnih sistemih, pametnih pogodbah, podatkih o zaposlenih, zaposlovanju in drugih področjih kadrovskega managementa.
Vrednotenje trajnostnega razvoja v industrijskem okolju
Authors: Žun Štefan , Mežnar Dušan
Published: January 2024

Koncept trajnostne proizvodnje se razvija s spremembami, ki jih narekujejo novi industrijski modeli. Za doseganje cilja trajnostne proizvodnje je potrebno slediti opredeljenim načelom, ki opredeljujejo trajnostno proizvodnjo na prehodu krožnega in digitaliziranega gospodarstva in doseganje cilja trajnostnega razvoja 12 (SDG12). To je mogoče doseči tudi s povečanjem učinkovitega obvladovanja snovnih in energijskih tokov v procesih odrezavanja. Pristopi so lahko različni. Osredotočili smo se na metode hlajenja in mazanja postopkov odrezavanja. Obravnavamo kriogene tehnologije obdelave, ki omogočajo znižanje proizvodnih stroškov procesov odrezavanja in izboljšanje konkurenčnosti z zmanjšanjem porabe virov in ustvarjanjem manj odpadkov. Vrednotenje obdelave odrezavanja je povzeto po raziskavah materialov (Inconel 718). Dokazano je, da stroški orodja močno prispevajo k skupnim proizvodnim stroškom in da kriogena obdelava odrezavanja ponuja čisto in stroškovno učinkovito pot za izboljšanje trajnostne učinkovitosti v primerjavi s konvencionalno obdelavo odrezavanja.
Vključevanje ergonomije v trajnostni razvoj organizacije
Authors: Medved Tilen , Balanti Zvone
Published: January 2024

Integracija ergonomije in trajnostnega razvoja postaja v sodobnih organizacijah vse bolj pomembna. Zato bomo s pregledom znanstvene literature preučili ključne pozitivne lastnosti vključevanja ergonomije v trajnostni razvoj organizacij in osvetlili glavne razlike med zgoraj omenjenima disciplinama. Z vključitvijo ergonomskih načel v pobude trajnostnega razvoja lahko organizacije izboljšajo svojo operativno učinkovitost, zmanjšajo tveganje za poškodbe ali nelagodje za zaposlene in stranke ter zmanjšajo svoj vpliv na okolje. Ta medsebojni vpliv med ergonomijo in trajnostnim razvojem lahko pomaga organizacijam pri doseganju njihovih ciljev glede trajnosti in prispeva k bolj trajnostni prihodnosti za vse deležnike. Celovita ocena trenutnih operacij in procesov, močna ekipa, strateški načrt, vključevanje deležnikov, stalno spremljanje in vrednotenje ter izobraževanje, oziroma ozaveščanje, so nekatere od najboljših praks, ki jim lahko organizacije sledijo za uspešno implementacijo ergonomije v trajnostni razvoj. Integracija ergonomije v trajnostni razvoj lahko prinese številne koristi, vključno z izboljšanim počutjem zaposlenih, večjo operativno učinkovitostjo in manjšim vplivom na okolje, kar je pomemben vidik za organizacije, ki želijo ustvariti bolj trajnostno prihodnost. Poleg priprave modela, smo analizirali tudi področja neskladij pri povezavi omenjenih strokovnih ved.
Modeliranje in integracija trajnostne oskrbovalne verige v industrijo
Authors: Mežnar Dušan , Žun Štefan
Published: January 2024

Osnovni namen tega poglavja je predstaviti pristop k modeliranju trajnostne oskrbovalne verige in integraciji modela trajnostnih praks v oskrbovalno verigo, pri čemer pa je cilj modeliranja in vključevanja trajnostnih praks v dobavne verige, izboljšati okoljsko, družbeno in ekonomsko uspešnost celotne dobavne verige, od pridobivanja surovin do dobave končnih izdelkov strankam. Ta vključuje tako zmanjšanje vpliva proizvodnje in logistike na okolje, kot tudi izboljšanje delovnih pogojev in pravičnega ravnanja z delavci ter spodbujanje etičnega pridobivanja materialov in izdelkov. Pričakovan rezultat implementacije trajnostnih praks pa privede tudi do prihranka stroškov, izboljšanja ugleda blagovne znamke in povečanja inovativnosti v dobavni verigi. Predstavljen model poskuša zaobjeti ključne elemente, ki so bistveni pri modeliranju in integraciji modela v realno okolje industrije, poudariti pa je potrebno, da so obravnavani opisi postopkov precej univerzalni in omogočajo uporabo v različnih panogah, kar pa pomeni, da je potrebno instrumente ali metode, ki se uporabljajo v praksi, prilagajati specifičnim lastnostim posameznih panog.
Caracterización de las arcillas de Sogamoso
Authors: Diaz Lagos Mercedes , López Aparicio Johana Hosyris , Alvarado Sánchez Juliana Andrea , Vergara Gómez Inés , Díaz Alarcón Jhonathan Andrés
Published: January 2024

En esta obra de divulgación converge la investigación sobre propiedades físicas, químicas, mineralógicas y petrográficas de recursos minerales arcillosos para contribuir en las problemáticas de producción de alfarería artesanal de la Asociación de  mujeres mineras y emprendedoras (ASOAMME) de la vereda Pantanitos en Sogamoso, Colombia. A partir de muestras provenientes de los tres títulos mineros que explota la asociación se determina la composición de las arcillas, sus propiedades  térmicas, plásticas y mineralógicas. Los análisis de fluorescencia de rayos X (FRX) determinan la composición química preliminar y guían la definición de los grupos minerales identificados mediante la difracción de rayos X (DRX) y la espectroscopía infrarroja con transformada de Fourier (FTIR). La interpretación de las fases minerales se complementa con microscopía óptica para identificar materiales como los cuarzos criptocristalinos y algunos minerales con granulometrías superiores a 5 μm. Asimismo,  se implementa microscopia electrónica de barrido (SEM) para reconocer las estructuras laminares de la caolinita y validar los  resultados de las técnicas analíticas. El comportamiento térmico se realizó mediante un análisis termogravimétrico (TGA) que  se ajustó a las propiedades mineralógicas de las arcillas y a la infraestructura en el taller alfarero de la Asociación. Los  resultados indican que las arcillas utilizadas por la Asociación presentan contenidos químicos diferenciales de caolinita y  montmorillonita, lo que modifica sus propiedades durante la cocción. Se concluye que las mezclas entre los diferentes niveles  de arcilla son poco recomendadas para elaborar piezas cerámicas. Los autores realizan un diagnóstico y formulan recomendaciones sobre el proceso de producción artesanal actual, sin afectar los procesos tradicionales. Se abordan aspectos como el manejo de las humedades, los controles de temperatura de cocción y la conveniencia de utilizar apliques o curvaturas.
Freedom and Self-Government: Ham Seok-heon’s Readings of Zhuangzi
Authors:   The Society for Asian Philosophy in Korea, Kim Si-Cheon
Published: January 2024

What does it mean to read Ham Seok-heon in the 21st century? Furthermore, what does it mean to read the ‘East-Asian Classics’ through him? In this article, I would like to raise a few issues that existing discussions on the relationship between Ham Seok-heon and the East-Asian Classics have not paid attention to, in order to point out the points that we should give more weight to in the hermeneutics of Ham Seok-heon’s ‘Chewing on Old Classics’. First, Ham’s should be read as an independent text in its own right, not as a commentary on the ‘Oriental Classics’. Second, his SSi-al’ Readings of Old Classics should be read in the context of life and place in contemporary Korea, rather than the Laozi and the Zhuangzi relationships it addresses. Third, the meanings and values in SSi-al’ Readings of Old Classics do not lie in its original interpretation of traditional commentaries, but rather in the “common sense” that guided the perceptions and practices of Ssi-al in the democratization process of twentieth-century Korea. To emphasize this aspect, I contrast it with the interpretation of the Zhuangzi in China during the same period. I want to argue that if Chinese intellectuals in the twentieth century anticipated their own destiny through the interpretation and discussion of the Zhuangzi, Ham Seok-heon’s reading of the Zhuangzi was expressed as the voice of Ssi-al, which changed the subject of interpretation and at the same time called for the values of modern freedom and equality and preached the ideology of democracy and self-government to realize them. In reading Ham Seok-heon in this way, I believe that we can properly evaluate the historical and philosophical meaning and value of SSi-al’ Readings of Old Classics.
A construção da norm@ jurídic@ no cyberspace
Authors: Ferreira Carlos Wagner Dias
Published: January 2024

Este ensaio almeja trazer singelo contributo ao recente debate na doutrina internacional se o direito produzido pelo Estado e, por conseguinte, as suas normas jurídicas, consegue regular o universo do cyberspace, em razão da postura refratária dos global players em aceitar qualquer interferência nesse ambiente. O esforço investigativo residirá, com base na análise do pensamento de vários autores internacionais que se dedicam a essa problemática, se, na sociedade tecnológica, da informação e do mundo digital, existe atualmente algum espaço reservado ao direito estatal no cyberspace e se haveria algum futuro a ele. Busca-se aquilatar como o direito há de proteger o homem que não quer essa proteção jurídica, preferindo as regras instituídas pelo próprio cyberspace. A presente investigação sobrevoa, inicialmente, sobre o terreno das características das normas jurídicas estatais e a função do próprio direito, enveredando o estudo para analisar como tem se revelado a produção de regras no ciberespaço pelo Code. Objetiva saber, à luz do método hipotético-dedutivo, se é possível construir possível norma jurídica que seja resultado da interação interpretativa entre as regras do Code e as normas de direitos humanos. O resultado, por sua vez, alcançado nesta pesquisa científica revela que o método aplicativo-normativo mais eficaz ao processo de regulação do cyberspace consiste em produzir interpretações interativas, desenvolvidas a partir da limitação das regras do Code pelas normas de direitos humanos.
Violência contra as mulheres no contexto pandêmico COVID 19: reflexões críticas acerca da intervenção do estado na proteção das mulheres vítimas de abusos domésticos
Authors: Santos Luiz Antonio , Neme Eliana Franco
Published: January 2024

O presente artigo aborda a questão da violência contra as mulheres no contexto da pandemia da Covid-19, problematizando a efetividade das intervenções estatais na proteção da mulher em casos de violência de gênero. A hipótese de pesquisa é que o isolamento social e as dificuldades enfrentadas durante a pandemia intensificaram a vulnerabilidade das mulheres, exigindo maior atenção do governo. Empregou-se o método dedutivo e como procedimento metodológico, foi realizada uma revisão de literatura em repositórios como Google Acadêmico, Scielo e banco de teses e dissertações com termos de inclusão: violência contra a mulher; violência familiar; coronavírus; covid-19; lei 11.340 e proteção do Estado. A relevância do presente estudo está no fato de que a vulnerabilidade da mulher aumentou muito no cenário da pandemia mundial, uma vez que medidas de isolamento social contribuíram de diversas maneiras para que esta situação se agravasse, requerendo ainda mais atenção por parte do governo na prevenção e punição dos agressores. Foi possível concluir através do presente estudo que a pandemia trouxe problemas sociais e de ordem financeira para milhões de pessoas em todo mundo, e que o isolamento social imposta como forma de reduzir os seus riscos, agravou a violência feminina, cujos casos de subnotificação ficaram ainda mais evidentes pela dificuldade de acesso aos transportes públicos, falta de opções de acolhimento e dependência do conjugue. A situação poderia ser minimizada com maior comprometimento do Estado, comunicação mais eficiente, a qual poderia ser feita através das redes sociais, e ações mais comedidas por parte do judiciário brasileiro em prol da soltura e proteção de bandidos, os quais fatalmente representarão maior risco da ocorrência de violência e feminicídio ao voltarem para suas companheiras.
O direito fundamental à saúde, o princípio da reserva do possível e o mínimo existencial: uma discussão em relação às doenças raras e o fornecimento de medicamentos
Authors: Almeida Michelle Aparecida Ganho , Séllos-Knoerr Viviane Coêlho de , Knoerr Fernando Gustavo
Published: January 2024

A saúde, sendo um direito social fundamental, constitui um dos mais importantes bens jurídicos consagrados na Constituição Federal Brasileira, sendo os medicamentos bens necessários a manutenção da saúde e como tal da dignidade humana.O objetivo geral do presente artigo é discorrer sobre o direito fundamental à saúde, especialmente dos portadores de doenças raras, como a doença do ciclo da ureia e sobre os princípios da reserva do possível e do mínimo existencial, com origem nas teorias alemã e norte-americana, trazidas para a ordem jurídico-constitucional brasileira e utilizados como elemento de defesa quando invocado o direito à saúde por medida judicial.O problema da pesquisa reside em verificar se o Poder Judiciário não estaria negando vigência a própria Constituição Federal, especialmente ao direito à saúde e a dignidade humana aos portadores de doenças raras, ao imputar o preenchimento de uma série de requisitos para a concessão de medicamentos não registrados na Anvisa e não incluídos na lista do SUS. O método de abordagem adotado é o dedutivo e o método de procedimento utilizado é o monográfico. A hipótese principal responde ao problema de pesquisa de modo a demonstrar que as decisões judiciais, diante da ausência de atuação do Poder Executivo e Legislativo frente a problemática da concessão de medicamentos não registrados na Anvisa aos portadores de doenças raras, buscam resolver o impasse, criando, em caráter excepcional, requisitos a serem preenchidos como forma de sopesar a antinomia entre as regras constitucionais de direito à saúde e à vida e as leis infraconstitucionais que exigem o mínimo procedimental para aceitação da utilização do medicamento no mercado brasileiro. Trata-se, pois, de dar atendimento ao direito à saúde e à vida, mas em conformidade com a comprovação da necessidade e eficácia do medicamento.
Developing an Effective Team-Based Emergency Training Program for Medical Students
Authors: Hartono Pinter , Adiyanto Bowo , Nur Rifdhani Fakhrudin , Ancilla Cornelia , Rahma Aulia Zuhria
Published: January 2024

Introduction: Team-based patient management in critical care demands a knowledgeable, skillful, and responsive doctor who collaborates well on teams. Medical education is responsible for producing competent graduates who meet the above requirements. However, the current medical curriculum in Indonesia tends to focus only on individual knowledge and appraisal. There was no standardized university-based group emergency training and examination with comprehensive emergency topics beyond cardiac and trauma cases. Objective: This study aimed to develop and evaluate a team-based emergency training program that enhances medical students' preparedness and teamwork skills in dealing with future emergencies in the workplace. Materials and Methods: We developed Acute Life Threatening Events Management (ALTEM), a three-day emergency training program consisting of pre-test, lectures, guided skill practice, group (case-based) simulation exam, and post-test. Group simulation occurred in a virtual hospital with high-fidelity mannequins, actual medical equipment (i.e., beds, monitors, drugs, tools, pads), two-way mirror rooms, and simulated patient family to resemble real hospital situations. The program was then evaluated by a modified Kirkpatrick evaluation model, which measures individual perception, satisfaction, understanding, and performance related to the program. Results: A total of 114 participants were involved in this study. Most subjects (>80%) had a good experience with the program. ALTEM training program significantly increased communication and teamwork (p <0.001) and decision-making towards critical patients (p <0.001) in the univariate analysis. Communication and teamwork remained related considerably in the multivariate analysis (aOR 7.866; p = 0.005). Conclusion: The ALTEM simulation program obtained a good response from the subjects and was a prospective program to improve medical students' competence and teamwork skills in emergencies.
Comparison of Intravenous Administration of Remifentanil with Fentanyl for Increased Blood Sugar Levels in Post Cardiac Surgery Patients
Authors: Irvan  , Tavianto Doddy , Sudjud Reza Widianto
Published: January 2024

Introduction: The incidence of hyperglycemia in patients with heart disease undergoing cardiac surgery reaches 50% in patients without a history of Diabetes Mellitus. This condition of hyperglycemia can increase morbidity and mortality. Objective: This study aims to assess the effect of using the agent remifentanil intravenously 0.5-1 µg/kgBW bolus followed by maintenance at a dose of 0.05-0.1 µg/kgBW/minute intravenously compared to the use of fentanyl 3-10 µg/kgBW followed by a maintenance dose of 0.03-0.1 µg/kgBW/minute for increased blood sugar levels in patients undergoing cardiac surgery with the Cardiopulmonary Bypass (CPB) procedure. Materials and Methods: This study is an experimental study with a single-blind randomized controlled design. Patients will be divided into 2 groups consisting of 12 patients each, namely group R (remifentanil) received remifentanil, and group F (fentanyl) received fentanyl. Blood sugar levels will be checked before and after surgery. Results: The research has been conducted at Dr. Hasan Sadikin Hospital Bandung from February 2023 to May 2023. The average increase in blood sugar levels in the remifentanil group was 74 mg/dl, while in the fentanyl group, it was 90 mg/dl. The p-value given is 0.214. Statistical test results showed that the value of p> 0.05. Conclusion: This study concludes that there is no significant difference in the increase in blood sugar levels between the two groups (remifentanil and fentanyl). This can be caused by the use of opioid doses in the lower range and more complex surgical procedures in our research.
Effect of Ultrasonic Assisted Extraction with Ethanol for Removing Lipid on Catfish (Pangasius sp.) Skin as a Collagen Source and Its Characteristics
Authors: Agustina Maulida , Patmawati Patmawati , Mubarok Shofy , Sulmartiwi Laksmi , Wulandari Diah Anggraini , Zai Khadijah , Siva Raseetha , Pujiastuti Dwi Yuli , Nirmala Dwitha , Carattri Kusuma Werdani Money , Moechthar Oemar , Alwi Husein Mohamad Akmal
Published: January 2024

Abstract
Fish skin is rich in collagen (80%-90%). However, catfish (Pangasius sp.) skin has a high lipid content, which can reduce the quality of collagen. Therefore, treatment is needed to remove the lipid using ultrasonic assisted extraction (UAE) with ethanol. Hence, the aim of the present study was to remove lipid content from catfish skin as a raw material for collagen by using UAE with different concentrations of ethanol (25, 50, and 75%). The research was conducted in three stages: removing impurities, collagen extraction, and characterization of collagen. The result exhibited that UAE-ethanol treatment was capable of removing up to 85.6% of lipid content, and the produced collagen had the potential to be utilized as an alternative source of collagen based on its properties.
Highlight Research

Ethanol could be used as extractor of lipid from catfish skin of Pangasius
Ultrasonic assisted extraction could increase efficiency of lipid extraction from catfish skin.
Fish skin of Pangasius sp. has a potential source for collagen.
Collagen from skin of Pangasius sp. has a good characteristic with high protein content.
Effects of Iodine Treatment on the Development of Eggs and Larvae of Rabbitfish (Siganus guttatus Bloch, 1787)
Authors: Huyền Kiều Thị  , Tran Vinh Phuong , Tran Nguyen Ngoc , Ngo Thi Huong Giang , Ho Ngoc Tram Anh , Nguyen Xuan Huy , Nguyen Quang Linh
Published: January 2024

Abstract
Iodine is proven to be an effective disinfectant for fish eggs and is commonly used in a hatchery to improve hatching and survival rates. However, tolerance to iodine can vary in different fish species, and it is essential to determine the optimal concentration to ensure successful hatchery production. This study investigated the optimum concentration and exposure time to iodine during incubation to improve rabbitfish larvae’s hatching and fertilization rate from 4/2022 – 8/2022 in Thua Thien Hue, Vietnam. The study consisted of two experiments: Experiment 1 focused on different iodine concentrations: 0 ppm (C1), 50 ppm (C2), 100 ppm (C3), and 150 ppm (C4). Experiment 2 explored three exposure times: 10 minutes (T1), 20 minutes (T2), and 30 minutes (T3) to increase the fertilization, hatching, and survival rates at five days post-hatching. Data were compiled, analyzed, and compared by ANOVA using SPSS ver. 22.0. The results showed that 100 ppm iodine concentration at 20 minutes of exposure resulted in the optimum hatching, fertilization, and survival rates of S. guttatus during artificial reproduction. In the future, integrated solutions in the use of iodine solution for egg treatment and natural food supplementation at the larval stage should be recommended to improve the efficiency in artificial hatchery production of Rabbitfish.
Highlight Research

The concentration and incubation time of rabbitfish (Siganus guttatus) eggs affect the production efficiency of fingerling fish.
Iodine concentration of 100ppm for 20 minutes is the best to treat fish eggs before incubation.
The fertilization rate of eggs, hatching rate, and survival rate of larva after 5 days of hatching when washing by iodine concentration of 100 ppm was 86.44 ±84%, 96.14 ± 1.05%, 58.65 ± 7.60% respectively.
Bias and fairness in software and automation tools in digital forensics
Authors: Jinad Razaq , Gupta Khushi , Simsek Ecem , Zhou Bing
Published: January 2024

The proliferation of software tools and automated techniques in digital forensics has brought about some controversies regarding bias and fairness. Different biases exist and have been proven in some civil and criminal cases. In our research, we analyze and discuss these biases present in software tools and automation systems used by law enforcement organizations and in court proceedings. Furthermore, we present real-life cases and scenarios where some of these biases have determined or influenced these cases. We were also able to provide recommendations for reducing bias in software tools, which we hope will be the foundation for a framework that reduces or eliminates bias from software tools used in digital forensics. In conclusion, we anticipate that this research can help increase validation in digital forensics software tools and ensure users' trust in the tools and automation techniques.
Mathematical modeling of physiological parameters in traumatic shock caused by lower limb blast injury
Authors: Tolmachev I. V. , Anisin A. V. , Bala A. M. , Vrazhnov D. A. , Shapovalov A. V. , Kotlovskiy M. Yu. , Laptev V. V. , Brazovskiy K. S.
Published: January 2024

The aim of this study was to apply integrative physiological mathematical models to simulate physiological parameters in traumatic shock caused by lower limb blast injury.

Materials and methods. At the first stage of mathematical modeling, we applied lumped parameter integrative physiological models, and at the second stage we used neural networks.

Results. We developed a clinical decision support system that allows to determine the intensity of blood loss in lower limb blast injuries according to physiological monitoring data.

Conclusion. The developed approaches make it possible to partially solve the problem associated with the impossibility of accumulating a sufficient amount of medical data for a specific person to create an adequate personalized clinical decision support system.
A method to evaluate the functional state of the human brain after acute in-hospital stroke
Authors: Brazovskii K. S. , Vinokurova D. A. , Strezh V. A. , Ussov V. Yu.
Published: January 2024

Acute in-hospital stroke is a severe complication of the early recovery period after cardiovascular surgery with a probability of up to 15%. Unfortunately, in-time diagnostic neuroimaging (computed tomography and magnetic resonance imaging) in cases of severe brain damages is considerably hindered increasing the risk of an adverse outcome.

The aim of the study was to develop a method to evaluate the functional state of the human brain in patients with severe in-hospital stroke measuring parameters of electrical activity in the central nervous system.

Materials and methods. The sample was composed of 20 anonymous archived electroencephalograms obtained from volunteers with no neurological disorders, 10 records of patients without neurological symptoms during general anesthesia, 17 records of patients with out-of-hospital strokes obtained from the UCLH Stroke EIT Dataset, and 18 records from patients with acute in-hospital stroke during neuromonitoring in the early postoperative recovery period. A new integral coefficient of the functional state was introduced, and an algorithm to calculate the proposed measure of the functional activity of the central nervous system was developed and implemented.

Results. The proposed method to evaluate the functional state of the human brain was applied to analyze neurophysiological records obtained from people with different activity of the nervous system: from resting state to deep coma. It was shown that the integral coefficient naturally reflects the functional state of the human brain and can be used for early detection of brain dysfunction and damages caused by cerebral hemodynamic impairment.

Conclusion. The introduced integral criterion to evaluate the functional state of the human brain can be used for long-term postoperative monitoring in cardiac patients who underwent surgical treatment.
Adipokine imbalance and its role in the pathogenesis of novel coronavirus infection
Authors: Bespalova I. D. , Mitrichenko U. M. , Kalyuzhin V. V. , Koroleva E. S. , Koshchavtseva Yu. I. , Romanov D. S. , Pershina D. E.
Published: January 2024

The review summarizes and analyzes the results of major foreign studies on the role of adipokine imbalance in the development of a severe course and complications of novel coronavirus infection (COVID-19). Adipokines are biologically active compounds produced by adipose tissue cells and involved in the regulation of metabolism and the functioning of the immune system. 

Obesity is a proven risk factor for severe COVID-19 due to high hormonal and metabolic activity of visceral adipose tissue. A deep understanding of COVID-19 pathogenesis from the point of view of the role of adipokine imbalance in it can provide the grounds for the development of effective pathogenetic approaches to the prevention of a severe course and complications of novel coronavirus infection.