bluuebunny/crossref_metadata_2025 huggingface dataset:
Digitalization of control and supervisory activities as a tool for combating corruption
Authors: Kuryndin Pavel Aleksandrovich
Published: July 2024

The subject of the study is the process of combating corruption, which, due to its changing forms and methods, should be permanent and comprehensive. Moreover, all levels of society are affected by corruption. Digitalization of administrative procedures makes it possible to increase the efficiency of public administration and ensure transparency of decisions. At the same time, it is necessary to assess how the goals and the reality of their implementation coincide. Russia has adopted yet another anti-corruption plan, which is "reinforced" by the introduction of a new Poseidon system that ensures compliance with anti-corruption requirements by various officials. However, the constant bias towards digitalization of administrative procedures and control and supervisory activities cannot automatically lead to the eradication of corruption. It only creates prerequisites. In addition, policy documents in Russia do not set such goals, including even existing international legal acts.  Digitalization has many advantages – it is the ease, simplicity and speed of decisions. In fact, the electronic form of control is convenient: you do not need to wait long, prepare documents, the control body can check everything at once. Also, digitalization has already shown effectiveness in reducing "everyday" corruption. However, there is no detailed statistics on the results of appealing control measures in open data. It is impossible to assess what was appealed, what decisions were made and what problems arose. At the same time, the ubiquitous electronic form will not get rid of negative phenomena – there is no single standard of interaction between an administrative body and a non-governmental entity. Regulatory legal acts do not take into account one important aspect: not all individuals have access to the Internet.
Comprehensive stimulation of the pharmaceutical industry as a factor in ensuring drug safety in the Russian Federation
Authors: Sekushin Aleksei Yur'evich
Published: July 2024

The subject of the study is comprehensive support tools based on the example of a SPIC, various aspects of the conclusion of a SPIC, requirements for companies when concluding a SPIC in relation to the pharmaceutical industry. The purpose of the study is to analyze complex support tools, identify problems based on the analysis of complex support tools using the example of SPIC in relation to the pharmaceutical industry. The author examines in detail such features of the SPIC as: requirements for the conclusion of a SPIC, tax and non-tax benefits when concluding a SPIC, the concepts of "obligations" in complex support tools, price regulation of medicines from the list of VED, administrative barriers, opacity of requirements for an investment project within the framework of the conclusion of a SPIC, penalties for deviations from targets, etc. other matters. This study was conducted on the basis of the application of general scientific research methods, including systematic, logical, comparative analysis, and the method of analogy. The main conclusions of the study are the relevance of comprehensive support tools, including SPIC. The SPIC is currently an important tool for comprehensive support for both the state and companies, as it offers serious tax and non-tax benefits, which has a positive effect on investment activity in the Russian Federation. At the same time, the author highlights relevant issues for the SPIC, including administrative barriers, price regulation of medicines from the list of VED, the parties with whom a potential investor concludes a SPIC, penalties. The scientific novelty lies in the analysis of problems during the conclusion of a SPIC that were not previously highlighted, including within the pharmaceutical industry, as well as the proposal of relevant directions for the development of a SPIC that can increase the attractiveness of this investment instrument.
Russia and Türkiye are on the path to progress in national anti-money laundering and counter-terrorism financing systems.
Authors: Koroleva Lyudmila Pavlovna , Evseeva YUliya Igorevna , Bezrukov Egor Vladimirovich
Published: July 2024

In 2022-2023, a number of international organizations of the global anti-money laundering and terrorist financing network, as well as financial intelligence units of the Western bloc countries, refused to cooperate with Russia. In these circumstances, it is necessary to expand international cooperation with friendly countries, including Turkey, a key foreign policy and trade partner of modern Russia. The article examines the national anti-money laundering and terrorist financing systems of Russia and Turkey. A comparative analysis of their technical compliance with the Recommendations of the Financial Action Task Force on Money Laundering (FATF) is carried out. The assessments of the effectiveness of the systems received by the countries within the framework of the 4th round of mutual assessments in 2019, as well as key countermeasures, are compared. General scientific research methods were used. The information was based on mutual assessment reports and progress reports from Russia and Turkey, as well as national laws on combating money laundering and terrorist financing. The comparative analysis was carried out for 2019-2023, during which countries made efforts to improve their national systems. As a result of the study, it was concluded that both countries have achieved significant progress in the development of national anti-money laundering and terrorist financing systems. Estimated 2023-2024 they comply or significantly comply with all FATF recommendations. At the same time, according to a number of recommendations, countries are superior or inferior to each other, which allows for the exchange of experience for further progress in this area. Thus, Russia is interested in Turkey's experience in establishing deterrent liability measures, identifying public officials and monitoring their operations, and interacting with third parties.
Long wavelength near-infrared II emitting Na3YSi3O9:x Cr3+ silicate and spectral broadening by multi-site occupancy
Authors: Gong Chang-Shuai , Wang Jian-Tong , Wang Bo-Wen , Xue Xu-Yan , Wang Xue-Jiao ,   School of Chemistry and Materials Engineering, Bohai University, Jinzhou 121013, China
Published: July 2024

Phosphors-converted near-infrared LED (pc-NIR LED) possesses applications in various fields including food quality analysis, night vision, biomedical imaging, and biomedicine. The design and development of broadband near-infrared (NIR) phosphors with the required properties are of decisive significance for pc-NIR LED devices. The Cr3+ doped phosphors are considered to be most promising near-infrared materials for commercialization. Broadband NIR luminescent materials doped with Cr3+ have attracted more and more attention due to their potential applications in NIR light sources. However, the emission wavelength of Cr3+ doped phosphor is generally located in the NIR I region of less than 850 nm, and realizing the NIR II region emission is still a challenge. In this work, a series of Cr3+ doped Na3YSi3O9 new silicate phosphors is prepared by solid-state method in N2 atmosphere at 1150 ℃ for 8 h. We take advantages of the silicate nature and the multi octahedral sites suitable for Cr3+ in the studied Na3YSi3O9 materials to redshift and broaden the spectrum. The phase, crystal structure, microstructure, photoluminescence, main emission peak decay and thermal stability of the samples are systematically studied. The results show that the prepared samples are pure phases, with uneven morphology, slight agglomeration, and the sizes in the micrometer range. The Cr3+ is located in the weak crystal field environment of Na3YSi3O9 lattice, with a Dq/B value of 2.29. Under the excitation of blue light at a wavelength of 485 nm, the strongest emission peaks of Na3Y1–x Si3O9:x Cr3+ phosphors are located at 984 nm (NIR II region), which is longer than those of most Cr3+ activated phosphors. Due to the multi-site occupation of Cr3+ in the lattice, the full width at half maximum (FWHM) of the emission spectrum is as high as 183 nm. The optimal doping concentration of Na3Y1–x Si3O9:x Cr3+ is 3%, and the quenching mechanism is the dipole-dipole interaction between Cr3+ ions. Fluorescence decay curves show that the luminescence lifetime of Na3Y0.97Si3O9:0.03Cr3+ sample gradually decreases with the increase of doping concentration and temperature. The results of the temperature-dependent spectra show that the emission intensity decreases in a temperature range from 298 K to 423 K, and the activation energy ΔE of Cr3+ is 0.157 eV.
Polarization modulation scanning optical microscopy method
Authors: Zhang Yang , Zhang Zhi-Hao , Wang Yu-Jian , Xue Xiao-Lan , Chen Ling-Xiu , Shi Li-Wei ,   School of Materials Science and Physics, China University of Mining and Technology, Xuzhou 221116, China
Published: July 2024

Since the discovery of monolayer graphene, the novel physical properties of two-dimensional (2D) materials, particularly those with fewer layers that often exhibit unique properties different from bulk materials, have received significant attention. Therefore, accurately determining the layer number or obtaining the microscopic surface morphology is crucial in the laboratory fabrication and during device manufacturing. However, traditional detection methods have numerous drawbacks. There is an urgent need for a convenient, accurate, and non-destructive scientific method to characterize the layer number and surface microstructure of 2D materials. By combining the experimental setup of laser scanning photocurrent spectroscopy, we develop a polarization-modulated scanning optical microscope based on the principle of reflectance difference spectroscopy. By monitoring the reflectivity of the samples, we can observe changes in the reflection signal strength of MoS2 with different layer numbers. The intensity of the reflectance differential spectral signal reflects changes in the layer count within the sample. We can characterize the changes in the number of layers of 2D materials in a non-contact manner by using polarization-modulated scanning optical microscopy. Through the study of the reflectance differential spectra of two typical 2D layered materials, MoS2 and ReSe2, we find that our polarization-modulated scanning optical microscope system is also more sensitive to the characteristics of the stacking anisotropy of the 2D materials than the conventional reflection microscope. This indicates that our research contributes to a better understanding of the layer number characteristics and anisotropic properties of layered 2D materials. Furthermore, our research also provides a non-contact optical method to characterize the number of layers and optical anisotropy of two-dimensional layered material.
Some notes on the relationships between intuitionistic fuzzy sets and correlation analysis
Authors: Michalíková Alžbeta ,   Faculty of Natural Sciences, Matej Bel University, Dudáš Adam ,   Mathematical Institute, Slovak Academy of Sciences,   Faculty of Natural Sciences, Matej Bel University
Published: July 2024

In the real world applications it is common that relationship between tuples of attributes of dimension higher than two need to be examined. It is well known that correlation analysis is focused on measuring of strength and direction of relationship between a pair of attributes. Algorithms using intercriteria analysis that solve the problem of measuring the strength of relationship between triples, quadruples, etc., were designed previously. The research presented in this paper is motivated by possibilities of using intuitionistic fuzzy equivalence relations to classify the data into the specific classes. The objective of this work is to use the values of correlation coefficients and compute the relationship between more than two attributes. The results are compared with the results obtained by intercriteria analysis.
Pushed to the edge: hundreds of myosin 10s pack into filopodia and could cause traffic jams on actin
Authors: Shangguan Julia , Rock Ronald S.
Published: July 2024

Myosin 10 (Myo10) is a motor protein well known for its role in filopodia formation. Although Myo10-driven filopodial dynamics have been characterized, there is no information about the absolute number of Myo10 molecules during the filopodial lifecycle. To better understand molecular stoichiometries and packing restraints in filopodia, we measured Myo10 abundance in these structures. Here we combined SDS-PAGE densitometry with epifluorescence microscopy to quantitate HaloTag-labeled Myo10 in U2OS cells. About 6% of total intracellular Myo10 localizes to filopodia, where it is enriched at opposite ends of the cell. Hundreds of Myo10 are found in a typical filopodium, and their distribution across filopodia is log-normal. Some filopodial tips even contain more Myo10 than accessible binding sites on the actin filament bundle. Live-cell movies reveal a dense cluster of over a hundred Myo10 molecules that initiates filopodial elongation. Hundreds of Myo10 molecules continue to accumulate during filopodial growth, but that accumulation ceases when filopodia begin to retract. Rates of filopodial elongation, second-phase elongation, and retraction are inversely related to Myo10 quantities. Our estimates of Myo10 molecules in filopodia provide insight into the physics of packing Myo10, its cargo, and other filopodia-associated proteins in narrow membrane compartments. Our protocol provides a framework for future work analyzing Myo10 abundance and distribution upon perturbation.
circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA
Authors: Okholm Trine Line Hauge , Kamstrup Andreas Bjerregaard , Nielsen Morten Muhlig , Hollensen Anne Kruse , Graversgaard Mette Laugesen , Sørensen Matilde Helbo , Kristensen Lasse Sommer , Vang Søren , Park Samuel S. , Yeo Gene W. , Dyrskjøt Lars , Kjems Jørgen , Pedersen Jakob Skou , Damgaard Christian Kroun
Published: July 2024

Circular RNAs (circRNAs) represent a class of widespread endogenous RNAs that regulate gene expression and thereby influence cell biological decisions with implications for the pathogenesis of several diseases. Here, we disclose a novel gene-regulatory role of circHIPK3 by combining analyses of large genomics datasets and mechanistic cell biological follow-up experiments. Specifically, we use temporal depletion of circHIPK3 or specific RNA binding proteins (RBPs) and identify several perturbed genes by RNA sequencing analyses. Using expression-coupled motif analyses of mRNA expression data from various knockdown experiments, we identify an 11-mer motif within circHIPK3, which is also enriched in genes that become downregulated upon circHIPK3 depletion. By mining eCLIP datasets, we find that the 11-mer motif constitutes a strong binding site for IGF2BP2 and validate this circHIPK3-IGF2BP2 interaction experimentally using RNA-immunoprecipitation and competition assays in bladder cancer cell lines. Our results suggest that circHIPK3 and IGF2BP2 mRNA targets compete for binding. Since the identified 11-mer motif found in circHIPK3 is enriched in upregulated genes following IGF2BP2 knockdown, and since IGF2BP2 depletion conversely globally antagonizes the effect of circHIPK3 knockdown on target genes, our results suggest that circHIPK3 can sequester IGF2BP2 as a competing endogenous RNA (ceRNA), leading to target mRNA stabilization. As an example of a circHIPK3-regulated gene, we focus on the
STAT3
mRNA as a specific substrate of IGF2BP2 and validate that manipulation of circHIPK3 regulates IGF2BP2-
STAT3
mRNA binding and thereby
STAT3
mRNA levels. However, absolute copy number quantifications demonstrate that IGF2BP2 outnumbers circHIPK3 by orders of magnitude, which is inconsistent with a simple 1:1 ceRNA hypothesis. Instead, we show that circHIPK3 can nucleate multiple copies of IGF2BP2, potentially via phase separation, to produce IGF2BP2 condensates. Finally, we show that circHIPK3 expression correlates with overall survival of patients with bladder cancer. Our results are consistent with a model where relatively few cellular circHIPK3 molecules function as inducers of IGF2BP2 condensation thereby regulating STAT3 and other key factors for cell proliferation and potentially cancer progression.
Evolutionary Adaptation of an HP1-protein Chromodomain Integrates Chromatin and DNA Sequence Signals
Authors: Baumgartner Lisa , Ipsaro Jonathan J. , Hohmann Ulrich , Handler Dominik , Schleiffer Alexander , Duchek Peter , Brennecke Julius
Published: July 2024

Members of the diverse heterochromatin protein 1 (HP1) family play crucial roles in heterochromatin formation and maintenance. Despite the similar affinities of their chromodomains for di- and tri-methylated histone H3 lysine 9 (H3K9me2/3), different HP1 proteins exhibit distinct chromatin binding patterns, likely due to interactions with various specificity factors. Here, we elucidate the molecular basis of the interaction between the HP1 protein Rhino, a crucial factor of the
Drosophila
piRNA pathway, and Kipferl, a DNA sequence-specific C
2
H
2
zinc finger protein and Rhino guidance factor. Through phylogenetic analyses, structure prediction, and
in vivo
genetics, we identify a single amino acid change within Rhino’s chromodomain, G31D, that does not affect H3K9me2/3 binding but disrupts the interaction between Rhino and Kipferl. Flies carrying the

rhino
G31D

mutation phenocopy
kipferl
mutant flies, with Rhino redistributing from piRNA clusters to satellite repeats, causing pronounced changes in the ovarian piRNA profile of

rhino
G31D

flies. Thus, Rhino’s chromodomain functions as a dual-specificity module, facilitating interactions with both a histone mark and a DNA-binding protein.
OpenNucleome for high resolution nuclear structural and dynamical modeling
Authors: Lao Zhuohan , Kamat Kartik , Jiang Zhongling , Zhang Bin
Published: July 2024

The intricate structural organization of the human nucleus is fundamental to cellular function and gene regulation. Recent advancements in experimental techniques, including high-throughput sequencing and microscopy, have provided valuable insights into nuclear organization. Computational modeling has played significant roles in interpreting experimental observations by reconstructing high-resolution structural ensembles and uncovering organization principles. However, the absence of standardized modeling tools poses challenges for furthering nuclear investigations. We present OpenNucleome—an open-source software designed for conducting GPU-accelerated molecular dynamics simulations of the human nucleus. OpenNucleome offers particle-based representations of chromosomes at a resolution of 100 KB, encompassing nuclear lamina, nucleoli, and speckles. This software furnishes highly accurate structural models of nuclear architecture, affording the means for dynamic simulations of condensate formation, fusion, and exploration of non-equilibrium effects. We applied OpenNucleome to uncover the mechanisms driving the emergence of “fixed points” within the nucleus—signifying genomic loci robustly anchored in proximity to specific nuclear bodies for functional purposes. This anchoring remains resilient even amidst significant fluctuations in chromosome radial positions and nuclear shapes within individual cells. Our findings lend support to a nuclear zoning model that elucidates genome functionality. We anticipate OpenNucleome to serve as a valuable tool for nuclear investigations, streamlining mechanistic explorations and enhancing the interpretation of experimental observations.
Homeostatic synaptic normalization optimizes learning in network models of neural population codes
Authors: Mayzel Jonathan , Schneidman Elad
Published: July 2024

Studying and understanding the code of large neural populations hinge on accurate statistical models of population activity. A novel class of models, based on learning to weigh sparse nonlinear Random Projections (RP) of the population, has demonstrated high accuracy, efficiency, and scalability. Importantly, these RP models have a clear and biologically-plausible implementation as shallow neural networks. We present a new class of RP models that are learned by optimizing the randomly selected sparse projections themselves. This “reshaping” of projections is akin to changing synaptic connections in just one layer of the corresponding neural circuit model. We show that Reshaped RP models are more accurate and efficient than the standard RP models in recapitulating the code of tens of cortical neurons from behaving monkeys. Incorporating more biological features and utilizing synaptic normalization in the learning process, results in even more efficient and accurate models. Remarkably, these models exhibit homeostasis in firing rates and total synaptic weights of projection neurons. We further show that these sparse homeostatic reshaped RP models outperform fully connected neural network models. Thus, our new scalable, efficient, and highly accurate population code models are not only biologically-plausible but are actually optimized due to their biological features. These findings suggest a dual functional role of synaptic normalization in neural circuits: maintaining spiking and synaptic homeostasis while concurrently optimizing network performance and efficiency in encoding information and learning.
The neural dynamics of positive and negative expectations of pain
Authors: Wittkamp Christoph A. , Wolf Maren-Isabel , Rose Michael
Published: July 2024

Pain is heavily modulated by expectations. Whereas the integration of expectations with sensory information has been examined in some detail, little is known about how positive and negative expectations are generated and their neural dynamics from generation over anticipation to the integration with sensory information. The present preregistered study employed a novel paradigm to induce positive and negative expectations on a trial-by-trial basis and examined the neural mechanisms using combined EEG-fMRI measurements (n=50). We observed substantially different neural representations between the anticipatory and the actual pain period. In the anticipation phase i.e., before the nociceptive input, the insular cortex, dorsolateral prefrontal cortex (DLPFC), and anterior cingulate cortex (ACC) showed increased activity for expectations regardless of their valence. Interestingly, a differentiation between positive and negative expectations within the majority of areas only occurred after the arrival of nociceptive information. FMRI-informed EEG analyses could reliably track the temporal sequence of processing showing an early effect in the DLPFC, followed by the anterior insula and late effects in the ACC. The observed effects indicate the involvement of different expectation-related subprocesses, including the transformation of visual information into a value signal that is maintained and differentiated according to its valence only during stimulus processing.
Ribosomal composition affects the noncanonical translation and toxicity of polyglycine-containing proteins in fragile X-associated conditions
Authors: Tutak Katarzyna , Broniarek Izabela , Zielezinski Andrzej , Niewiadomska Daria , Baud Anna , Sobczak Krzysztof
Published: July 2024

Expansion of CGG repeats (CGGexp) in the 5’ untranslated region (5’UTR) of the
FMR1
gene underlies the fragile X-associated conditions including tremor/ataxia syndrome (FXTAS), a late-onset neurodegenerative disease. One pathomechanism of FXTAS is the repeat-associated non-AUG-initiated (RAN) translation of CGG repeats of mutant
FMR1
mRNA, resulting in production of FMRpolyG, a toxic protein containing long polyglycine tract. To identify novel modifiers of RAN translation we used an RNA-tagging system and mass spectrometry-based screening. It revealed proteins enriched on CGGexp-containing
FMR1
RNA in cellulo, including a ribosomal protein RPS26, a component of the 40S subunit. We demonstrated that RPS26, together with its chaperone TSR2, modulates FMRpolyG production and its toxicity. We also found that the number of proteins produced via RPS26-sensitive translation was limited, and 5’UTRs of mRNAs encoding these proteins were guanosine and cytosine-rich. Moreover, the silencing of another component of the 40S subunit, the ribosomal protein RPS25, also induced repression of FMRpolyG biosynthesis. Results of this study suggest that the composition of the 40S subunit plays important role in noncanonical CGGexp-related RAN translation.
Malatl fine-tunes bone homeostasis by orchestrating cellular crosstalk and the β-catenin-OPG/Jagged1 pathway
Authors: Qin Yongli , Shirakawa Jumpei , Xu Cheng , Chen Ruge , Ng Courtney , Nakano Shinichi , Elguindy Mahmoud , Deng Zhonghao , Prasanth Kannanganattu V , Eissmann Moritz F. , Nakagawa Shinichi , Ricci William M. , Zhao Baohong
Published: July 2024

The IncRNA Malat1 was initially believed to be dispensable for physiology due to the lack of observable phenotypes in Malat1 knockout (KO) mice. However, our study challenges this conclusion. We found that both Malat1 KO and conditional KO mice in the osteoblast lineage exhibit significant osteoporosis. Mechanistically, Malat1 acts as an intrinsic regulator in osteoblasts to promote osteogenesis. Interestingly, Malat1 does not directly affect osteoclastogenesis but inhibits osteoclastogenesis in a non-autonomous manner
in vivo
via integrating crosstalk between multiple cell types, including osteoblasts, osteoclasts and chondrocytes. Our findings substantiate the existence of a novel remodeling network in which Malat1 serves as a central regulator by binding to β-catenin and functioning through the β-catenin-OPG/Jagged1 pathway in osteoblasts and chondrocytes. In pathological conditions, Malat1 significantly promotes bone regeneration in fracture healing. Bone homeostasis and regeneration are crucial to well-being. Our discoveries establish a previous unrecognized paradigm model of Malat1 function in the skeletal system, providing novel mechanistic insights into how a lncRNA integrates cellular crosstalk and molecular networks to fine tune tissue homeostasis, remodeling and repair.
Palabras en la camera obscura (sobre la poesía de Augusto de Campos)
Authors: Aguilar Gonzalo
Published: July 2024

El presente ensayo analiza la obra de Augusto de Campos y su relación con la poesía visual. A partir del uso que hace el poeta brasileño de la página en negro para componer sus poemas, se propone una lectura de su obra en relación con el legado de Mallarmé y su idea de la escritura. Posteriormente, a partir de la idea de la materialidad de la lengua poética que está en el centro del proyecto poético de Augusto de Campos, se plantea el pasaje hacia una dimensión háptica que se produce en sus poemas, sobre todo en “Anticéu” (“Anticielo”) de 1984.
Los “Salmos de Vísperas” de Juan Pedro Esnaola: presencia del italianismo en su estilo temprano (ca. 1822-1828)
Authors: Pedrotti Clarisa
Published: July 2024

Los “Salmos de Vísperas” de Juan Pedro Esnaola, hasta el momento opus unicum fuera del catálogo del compositor, fueron encontrados en Córdoba (Argentina) y reestrenados en 2017. A través del análisis hermenéutico, son puestos en relación con otras obras del autor (“Tercia”, “Misa a 3” y “Responso a 8”) para establecer su datación en base a pautas estilísticas. Todo corresponde a las primeras décadas del siglo XIX, entre 1828 y 1830, y a las características que propone Illari (2009) en relación con el estilo temprano en la música religiosa del compositor. Este sustantivo hallazgo nos invita a repensar algunas cuestiones acerca de la figura de Esnaola y estimar su circulación en un contexto ciertamente más amplio que los estrechos límites de la ciudad de Buenos Aires, a la vez que abre interesantes perspectivas para el conocimiento de la recepción del italianismo en las urbes de América del Sur a principios del siglo XIX.
La Biblioteca Musical de Isidora Zegers (1803-1869) y el Álbum Musical de Ángela Peralta (1845-1883): ópera y tópicos sentimentales durante el siglo XIX en Latinoamérica
Authors: Vera Malhue Fernanda
Published: July 2024

La práctica musical femenina burguesa en Latinoamérica tuvo características específicas que se asociaron a la cultura del siglo XIX. La ópera italiana, como expresión central de la cultura y del modelo civilizatorio, así como el gran influjo de la música de salón se reflejaron en la formación femenina. La educación de la época, de tipo romántico e ilustrado, impulsó una asociación de algunos sentimientos con lo femenino, y se incentivó la expresión de ciertas emociones consideradas como más apropiadas para las mujeres. En el presente artículo caracterizo lo anterior de dos formas distintas. Primero, con la reseña de la Biblioteca Musical de Isidora Zegers que incidió en la difusión del estilo lírico italiano en Santiago de Chile y, luego, mediante la descripción del Álbum Musical de Ángela Peralta que encarna, a través del empleo de títulos sentimentales en danzas y otras piezas de salón, la expresión emocional propia del lirismo italiano.
A espiritualidade no ambiente de trabalho de motoristas profissionais atuantes no transporte rodoviário de cargas
Authors: Milesi Bruno , Vieira Guilherme Bergmann Borges , Gonçalves Roberto Birch , Verruck Fábio
Published: July 2024

Este estudo teve como objetivo identificar o nível de espiritualidade no trabalho dos motoristas profissionais atuantes no transporte rodoviário de cargas. Para tanto, realizou-se uma pesquisa quantitativa utilizando o Inventário de Espiritualidade no Trabalho (IET-29, versão reduzida) de Siqueira et al. (2014). O questionário foi aplicado em uma amostra de 54 motoristas profissionais de uma empresa transportadora localizada no sul do Brasil. Os dados foram submetidos a análises de alfa de Cronbach para avaliar a confiabilidade do instrumento, análises descritivas com o propósito de explorar os dados coletados e verificação de correlações, visando mensurar a relação entre as variáveis. Os resultados da pesquisa indicaram que as dimensões “senso de comunidade” (SC) e “trabalho como propósito de vida” (TPV) apresentam altos índices de confiabilidade e contribuição para o “Inventário de Espiritualidade no Trabalho” (IET). Também foram identificadas associações significativas entre algumas variáveis como “número de filhos” e “trabalho com propósito de vida” e “faixa salarial” e “desempenho individual". Essas descobertas contribuem significativamente para a compreensão e aprimoramento das práticas de gestão de recursos humanos e remuneração na empresa estudada.
DETERMINANTS OF PAYMENT INNOVATION AMONG DEPOSIT MONEY BANKS IN NIGERIA: A REVIEW OF LITERATURE
Authors: FOLAMI Rahmon Abiodun , SOMOYE Russell O. Christopher , ILO Muzliu Bamidele
Published: July 2024

Payment innovation plays the central role in enhancing efficiency, accessibility, and financial inclusion within the banking sector, particularly in emerging economies like Nigeria. Through a systematic review of relevant literature, this study synthesises relevant theories and empirical studies to identify gaps in understanding the factors driving payment innovation among DMBs in Nigeria. The review reveals several key determinants influencing payment innovation among DMBs in Nigeria, including bank size, perceived usefulness, regulatory capital, research and development, human capital development, asset quality, leverage, and investment in information and communication technology (ICT). However, the study identified a significant research gap in establishing the directional relationship between these factors and payment innovation outcomes in the Nigerian banking context. Based on the findings, the paper recommends conducting empirical investigations to elucidate the causal relationships between DMBs in Nigeria and the identified determinants of payment innovation. In conclusion, this paper underscores the importance of understanding the determinants driving payment innovation among DMBs in Nigeria. By bridging the research gap through empirical investigations, stakeholders can better navigate the complexities of the banking industry and foster an environment conducive to on-going innovation and growth.
THE PLAN OF INTEGRATED MARKETING COMMUNICATION WITH EMPHASIS ON DESIGNING A STRATEGY FOR THE BRAND X
Authors: VUKASOVIC Tina , RAJER Jasna
Published: July 2024

Purpose: The article discusses the plan of integrated marketing communication with an emphasis on designing a strategy for the brand X. Marketing communication is one of the key elements of strategic marketing, as it has a significant impact on the recognition and success of a company or brand. It should be emphasized that in the era of information technology, information overload, and increasing consumer demands, the concept of marketing communication is much more complex than simply informing target customers about the existence of a product or service. Methodology: The quantitative research was carried out using a survey questionnaire technique. For this purpose, we used a web-based 1KA survey sent via email addresses. Results: The survey determined (1) the level of general interest in alarm systems for the protection of residential, holiday, and commercial properties, (2) the level of awareness of brand X. We further identified (3) the target audience of the brand X, (4) the key message for advertising needs and (5) communication channels through which to address the target audience. Practical implications: The obtained results were our key guidelines in designing a marketing communication strategy for the brand X, aimed at improving the effectiveness of current marketing campaigns and increasing the sales of products under the selected brand.
Compact VOC emission test chamber
Authors: Samborski Tomasz ,   Łukasiewicz Research Network – Institute for Sustainable Technologies, Kazimierza Pułaskiego 6/10, 26-600  Radom, Poland, Siczek Mariusz , Zbrowski Andrzej , Łożyński Łukasz , Kozioł Stanisław
Published: July 2024

The publication presents the test method and construction of a compact VOC emission test chamber. Volatile organic compounds (VOCs) are mainly occur in paint and construction materials containing chemical resins, bitumen, binders, adhesives, etc., as well as residues of unreacted monomers. VOC emission testing is carried out on product samples in environmental chambers in accordance with PN-EN ISO 16000-9. The developed chamber, together with a proprietary control and test parameter acquisition system, allows testing at a stabilized temperature and humidity of air washing over the sample at a specified rate. Qualitative identification and quantitative testing of compounds present in the air inside chambers is carried out using a chromatograph, and the test results are compared with regulations on permissible chemical pollutants in the air of buildings and in atmospheric air. The developed chamber with horizontal sample loading is another version of VOC chambers, developed in response to market demands, offered and implemented in research laboratories by the Łukasiewicz Institute for Sustainable Technologies in Radom.
The Influence of Asset Valuation, Asset Inventory, and Legal Audit on Asset Optimization
Authors: Amin Aminul , Mauludin Hanif , Mufidah Laili
Published: July 2024

This study aims to fill a gap in the asset management literature by analysing the impact of asset inventory, legal audits, and asset valuation practices on asset optimization. The study involved 106 employees who participated in the completion of the questionnaire. The data was analysed using multiple regressions to test the proposed hypothesis. The results showed that asset inventory has a significant influence on asset optimisation. Asset inventory aims to ensure that company assets are recorded completely and accurately. A legal audit has a significant effect on asset optimisation. The implementation of legal audits to ensure regulatory asset control can increase asset optimisation. Asset valuation has a significant effect on asset optimisation. Consistent and proper asset valuation helps determine market value or tax needs. This research makes an empirical contribution to asset management theory, showing that planning, procurement, operation, and maintenance of assets are necessary to achieve optimisation. The findings provide a foundation for companies to balance policies and best practices to sustainably increase asset value. In addition, these findings are expected to be a reference for further research in the field of asset management and provide practical solutions for other companies facing similar problems.
Effect of Vermicompost and Inorganic Fertilizer on Physico-chemical Properties of Soil on Cowpea (Vigna unguiculata)
Authors: Raj Raksha , Swaroop Narendra , Thomas Tarence , Mohanta Satya Ranjan , Thomas Ashima
Published: July 2024

Keeping this in view on experiment is present with the following objective:
To evaluate the effect of different doses of vermicompost with NPK on physico-chemical properties of soil.
The soil of experimental area falls in order Inceptisol and soil texture was sandy loam (sand % 62.65, silt % 21.09 and clay % 16.26). The design applied for statistical analysis was carried out with randomized block design with three levels of @NPK 0, 50, and 100% ha-1 and three levels of @Vermicopost 0, 50 and 100% ha-1 respectively. The best treatment was effect on physical and chemical property of soil T9 (@100%NPK+ 100% Vermicompost) and yield Attributes T9 (@100%NPK+ 100% Vermicompost) of cowpea. The largest percentages of pore space (%) with depths of 0–15 cm and 15–30 cm, 46.22% and 45.39%, water holding capacity (%) of 42.28% and 43.34%, and organic carbon (%) of 0.40% and 0.38% were found in the post-harvest soil and pre- harvest plant. There were 299.43 kg ha-1 and 293.36 kg ha-1 of available nitrogen, 22.34 kg ha-1 and 21.67 kg ha-1 of available phosphorus, and 179.84 kg ha-1 and 176.43 kg ha-1 of available potassium. The combination of T9-(@100%NPK+100% Vermicompost) demonstrated non-significant differences in particle density (Mg m-3) of 2.45 and 2.47 Mg m-3, pH of 6.89 and 6.91, and EC(dS m- 1) in bulk density (Mg m-3) with depth 0-15 cm and 15-30 cm, which was 1.40 and 1.41 Mg m-3, particle density (Mg m-3) was 2.45 and 2.47 Mg m-3 pH was 6.89 and 6.91 and EC(dS m-1) 0.46 dS m-1 and 0.50 dS m-1.
A Case of Leiomyosarcoma of the Femoral Artery; Rare Location and Management at an Advanced Stage
Authors: Traoré Hamadoun , Kouanga Andy J. , Mokhlis Mohammed Anouar , Papys Mendes , Elm’hadi Choukri , Tanz Rachid , Errihani Hassan
Published: July 2024

Vascular leiomyosarcomas are extremely rare tumours, accounting for less than 1% of all malignant tumours. Venous leiomyosarcomas occur five times more frequently than arterial leiomyosarcomas. These are most often found in the large vessels and less than 50% occur in the peripheral circulation. Median survival has not been quantified. It can be good if radical surgery is performed. Treatment, whatever the stage, requires multidisciplinary management. Surgery with en bloc resection remains the treatment of choice for localised disease; in patients with unresectable locally advanced or metastatic disease, systemic treatment with essentially palliative aims may be proposed. Anthracycline-based treatment is the standard first-line therapy.
We report a case report of a 50-year-old female patient with local, pulmonary and bone relapse of an operated left femoral artery leiomyosarcoma in whom we undertook palliative mono-chemotherapy.
Conclusion: Vascular leiomyosarcomas are extremely rare tumours, accounting for less than 1% of all malignant tumours. Median survival is dramatic for metastatic patients, with a median survival of 8 months, ranging from 5 to 20 months. Surgery remains the standard curative treatment for the localised stage; for stage 4, single chemotherapy is the treatment of choice.
Variation in Leaf Biochemical Compositon of Guava (Psidium guajava L) Hybrids
Authors: Lokesh G. , Priya B. Tanuja , Srinivasulu B. , Prasad M. Siva , Sadarunnisa Syed , Jayaprada M. , Arunodhayam K.
Published: July 2024

Interplay of several internal development cues leads to floral induction in perennials like guava, mango and litchi. The transition of plants from the vegetative to the reproductive phase depends on the biochemical composition of the leaves. In view of this, the present study was conducted to know the variation in biochemical composition in non-flowering and flowering guava plants. Seven guava hybrids H1 (ARP selection x Lalit), H2 (Lalit x ARP selection), H3 (Allahabad Safeda x ARP selection), H4 (Lalit x Allahabad Safeda), H5 (Allahabad Safeda x Lalit), H6 (Nagpur Seedless x Allahabad Safeda) and OP (Open pollinated progeny of Allahabad Safeda).) were used for estimation of biochemical constituents in blooming and non-blooming plants. Results revealed that higher levels of total sugars, protein, and carbohydrates were observed in the leaves of non-blooming plants compared to blooming plants. However, compared to non-flowered plants, flowering plants had leaves with a higher amount of total phenol.
O COMPLEMENTO DE CONSIDERAR COMO UMA ESTRUTURA ESPECIFICACIONAL
Authors: Da Silva Douglas Alan
Published: July 2024

Neste artigo, investigamos, no português brasileiro, o complemento interno do verbo considerar quando composto por DPs em ordem inversa e as sentenças copulativas simples classificadas como especificacionais. Objetivamos confrontar tais ambientes sintáticos quanto à sua lexicalização e leitura, com a finalidade de saber se o complemento de considerar é também uma estrutura especificacional, o que, por meio dos parâmetros citados, concluímos afirmativamente. Constatamos que as possibilidades e restrições composicionais de um são também averiguadas no outro, que os DPs de ambos são referencialmente assimétricos, distribuídos na ordem não referencial - referencial, e ocorrem sob contexto identificacional, marcados, respectivamente, para pressuposição - foco.
Deprem Kaygısı Ölçeği'nin Geliştirilmesi: Geçerlik ve Güvenirlik Çalışması
Authors: Bayram Hüseyin
Published: July 2024

Bu araştırmada depremi deneyimlemiş ortaokul kademesindeki ergenlerin deprem kaygı düzeylerini ölçebilecek bir ölçme aracının geliştirilmesi amaçlanmıştır. Nicel araştırma yöntemlerinden betimsel tarama modeliyle gerçekleştirilen araştırmanın çalışma grubunu 6 Şubat 2023’te Türkiye’nin Kahramanmaraş ilinde meydana gelen depremlerin etkilediği illerden Diyarbakır, Malatya, Adıyaman ve Gaziantep’teki ortaokullarda eğitim gören 10-14 yaşları arasındaki toplam 866 ergen birey oluşturmuştur. Ölçeğin yapı geçerliğini belirlemek için iki farklı grup üzerinden faktör analizleri yapılmıştır. Öncelikle açımlayıcı faktör analizi ile ölçeğin tek faktörden oluştuğu ve toplam varyansın % 64.34’ünü açıkladığı belirlenmiştir. Ardından gerçekleştirilen doğrulayıcı faktör analizi sonucunda tek faktörlü ölçeğin yapısı bir model olarak doğrulanmıştır. Ölçeğin güvenirlik çalışması için Cronbach Alpha katsayısı ve madde toplam korelasyonları hesaplanmış ve alt % 27’lik-üst % 27’lik grupların karşılaştırması yapılmıştır. Araştırma sonuçları, ortaokul kademesindeki ergenlerin deprem kaygı düzeyini ölçmek için geliştirilen ölçeğin geçerli, güvenilir ve kullanışlı bir ölçme aracı olduğunu göstermiştir.
Mosaicism for genome‐wide paternal uniparental disomy with features of multiple imprinting disorders: Diagnostic and management issues
Authors: Inbar‐Feigenberg Michal , Choufani Sanaa , Cytrynbaum Cheryl , Chen Yi‐An , Steele Leslie , Shuman Cheryl , Ray Peter N. , Weksberg Rosanna
Published: December 2012

Mosaicism for genome‐wide paternal uniparental disomy (UPD) has been reported in only seven live born individuals to date. Clinical presentation includes manifestations of multiple paternal UPD syndromes with high variability, likely due to the variable levels of mosaicism in different somatic tissues. We report an eighth case in a female patient with mosaicism for genome‐wide paternal UPD which highlights the complex clinical presentation. Our patient had features of Beckwith–Wiedemann syndrome (BWS), Angelman syndrome, and congenital hyperinsulinism. The clinical findings included prematurity, organomegaly, hemihyperplasia, developmental delay, benign tumors, and cystic lesions. The diagnosis in our patient was established utilizing microarray‐based genome‐wide DNA methylation analysis performed on leukocyte DNA. Targeted multiplex ligation‐dependent probe amplification (MLPA) analysis of chromosome regions 11p15 and 15q13 confirmed mosaicism for paternal UPD at these genomic regions. This case represents the first report of microarray‐based genome‐wide DNA methylation analysis in the diagnosis of genome‐wide paternal UPD. The application of microarray‐based genome‐wide DNA methylation analysis on selected individuals with complex clinical presentations could be a valuable diagnostic tool to improve the detection rate of mosaic genome‐wide paternal UPD. This approach, which screens many loci simultaneously, is more cost‐effective and less labor‐intensive than performing multiple targeted DNA methylation‐based assays. Identification of individuals with mosaicism for genome‐wide paternal UPD is an important goal as it confers a low recurrence risk for the family and identifies individuals who require surveillance due to increased tumor risk. © 2012 Wiley Periodicals, Inc.
Hyperinsulinemic hypoglycemia of infancy in Sotos syndrome
Authors: Matsuo Terumichi , Ihara Kenji , Ochiai Masayuki , Kinjo Tadamune , Yoshikawa Yoko , Kojima‐Ishii Kanako , Noda Marie , Mizumoto Hiroshi , Misaki Maiko , Minagawa Kyoko , Tominaga Koji , Hara Toshiro
Published: December 2012

Sotos syndrome (OMIM #117550) is a congenital syndrome characterized by overgrowth with advanced bone age, macrocephaly, and learning difficulties. Endocrine complications of this syndrome have not yet been fully described in previous reports. We here investigated the clinical manifestations of Sotos syndrome in Japanese patients who presented with hyperinsulinemic hypoglycemia of infancy. We recruited patients diagnosed as having Sotos syndrome who presented with the complication of hyperinsulinemia during the neonatal period using a survey of the abstracts of Pediatric Meetings in domestic areas of Japan from 2007 to 2011. As a result, five patients (four females and one male) were recruited to evaluate the clinical presentation of Sotos syndrome by reference to the clinical record of each patient. A 5q35 deletion including the NSD1 gene was detected in all patients. Major anomalies in the central nervous, cardiovascular, and genito‐urinary systems were frequently found. Hypoglycemia occurred between 0.5 and 3 hr after birth and high levels of insulin were initially found within 3 days of birth. The patients were treated with intravenous glucose infusion at a maximum rate of 4.6–11.0 mg/kg/min for 12–49 days. Three of the five patients required nasal tube feeding. One patient received medical treatment with diazoxide. This study shows that patients with Sotos syndrome may present with transient hyperinsulinemic hypoglycemia in the neonatal period. © 2012 Wiley Periodicals, Inc.