bluuebunny/crossref_metadata_2025 huggingface dataset:
Coil Migration after Transarterial Coil Embolization of a Splenic Artery Pseudoaneurysm
Authors: Tekola Bezawit D. , Arner David M. , Behm Brian W.
Published: November 2013

A 48-year-old man with a history of splenic artery pseudoaneurysm requiring transarterial embolization 3 months earlier presented to the emergency department with abdominal pain and fever. Computed tomography showed evidence of embolization coil fragments within the gastrointestinal tract. Upper endoscopy showed a large gastric ulcer with numerous embolization coils extruding into the gastric lumen. The patient underwent partial gastrectomy, distal pancreatectomy and resection of the splenic artery pseudoaneurysm. This case illustrates a rare delayed complication of transarterial embolization of a splenic artery pseudoaneurysm.
Hemodynamic Response to Intravenous Adenosine and Its Effect on Fractional Flow Reserve Assessment
Authors: Tarkin Jason M. , Nijjer Sukhjinder , Sen Sayan , Petraco Ricardo , Echavarria-Pinto Mauro , Asress Kaleab N. , Lockie Tim , Khawaja Muhammed Z. , Mayet Jamil , Hughes Alun D. , Malik Iqbal S. , Mikhail Ghada W. , Baker Christopher S. , Foale Rodney A. , Redwood Simon , Francis Darrel P. , Escaned Javier , Davies Justin E.
Published: November 2013

Background—

We studied the hemodynamic response to intravenous adenosine on calculation of fractional flow reserve (FFR). Intravenous adenosine is widely used to achieve conditions of stable hyperemia for measurement of FFR. However, intravenous adenosine affects both systemic and coronary vascular beds differentially.

Methods and Results—

A total of 283 patients (310 coronary stenoses) underwent coronary angiography with FFR using intravenous adenosine 140 mcg/kg per minute via a central femoral vein. Offline analysis was performed to calculate aortic (Pa), distal intracoronary (Pd), and reservoir (Pr) pressure at baseline, peak, and stable hyperemia. Seven different hemodynamic patterns were observed according to Pa and Pd change at peak and stable hyperemia. The average time from baseline to stable hyperemia was 68.2±38.5 seconds, when both ΔPa and ΔPd were decreased (ΔPa, −10.2±10.5 mm Hg; ΔPd, −18.2±10.8 mm Hg;
P
<0.001 for both). The fall in Pa closely correlated with the reduction in peripheral Pr (ΔPr, −12.9±15.7 mm Hg;
P
<0.001;
r
=0.9;
P
<0.001). ΔPa and ΔPd were closely related under conditions of peak (
r
=0.75;
P
<0.001) and stable hyperemia (
r
=0.83;
P
<0.001). On average, 56% (10.2 mm Hg) of the reduction in Pd was because of fall in Pa. FFR lesion classification changed in 9% using an FFR threshold of ≤0.80 and 5.2% with FFR threshold <0.75 when comparing Pd/Pa at peak and stable hyperemia.

Conclusions—

Intravenous adenosine results in variable changes in systemic blood pressure, which can lead to alterations in FFR lesion classification. Attention is required to ensure FFR is measured under conditions of stable hyperemia, although the FFR value at this point may be numerically higher.
Determinants of Erythrocyte Omega‐3 Fatty Acid Content in Response to Fish Oil Supplementation: A Dose–Response Randomized Controlled Trial
Authors: Flock Michael R. , Skulas‐Ray Ann C. , Harris William S. , Etherton Terry D. , Fleming Jennifer A. , Kris‐Etherton Penny M.
Published: November 2013

Background

The erythrocyte membrane content of eicosapentaenoic acid (
EPA
) and docosahexaenoic acid (
DHA
), which constitutes the omega‐3 index (O3I), predicts cardiovascular disease mortality. The amount of
EPA
+
DHA
needed to achieve a target O3I is poorly defined, as are the determinants of the O3I response to a change in
EPA
+
DHA
intake. The objective of this study was to develop a predictive model of the O3I response to
EPA
+
DHA
supplementation in healthy adults, specifically identifying factors that determine the response.

Methods and Results

A randomized, placebo‐controlled, double‐blind, parallel‐group study was conducted in 115 healthy men and women. One of 5 doses (0, 300, 600, 900, 1800 mg) of
EPA
+
DHA
was given daily as placebo or fish oil supplements for ≈5 months. The O3I was measured at baseline and at the end of the study. There were no significant differences in the clinical characteristics between the groups at baseline. The O3I increased in a dose‐dependent manner (
P
<0.0001), with the dose of
EPA
+
DHA
alone accounting for 68% (quadratic,
P
<0.0001) of the variability in the O3I response. Dose adjusted per unit body weight (g/kg) accounted for 70% (linear,
P
<0.0001). Additional factors that improved prediction of treatment response were baseline O3I, age, sex, and physical activity. Collectively, these explained 78% of the response variability (
P
<0.0001).

Conclusions

Our findings validate the O3I as a biomarker of
EPA
+
DHA
consumption and identify additional factors, particularly body weight, that can be used to tailor
EPA
+
DHA
recommendations to achieve a target O3I.
Venous sac embolization of pulmonary arteriovenous malformation: safety and effectiveness at mid-term follow-up
Authors: Kajiwara Kenji , Urashima Masaki , Yamagami Takuji , Kakizawa Hideaki , Matsuura Noriaki , Matsuura Akiko , Ohnari Tae , Ishikawa Masaki , Awai Kazuo
Published: November 2013

Background

The standard technique for the transcatheter treatment of pulmonary arteriovenous malformations (PAVMs) involves deploying coils into the feeding arteries. We investigated whether venous sac embolization would also be a safe and useful treatment method.

Purpose

To evaluate the safety and outcomes of venous sac embolization for PAVMs.

Material and Methods

This study included 15 consecutive patients (1 man, 14 women; mean age, 54 years; range, 22–76 years) with 50 PAVMs who underwent 26 procedures; four had a history of earlier cerebral infarction or exertional dyspnea. We first placed 0.018-inch interlocking detachable and/or 0.018-inch or 0.010-inch Guglielmi detachable coils to prevent systemic migration from the venous sac. We then packed the sac as tightly as possible and embolized the orifice at the proximal feeding artery. We used angiographic, clinical, and computed tomography (CT) studies to evaluate the treatment outcomes and safety of these procedures. The mean follow-up was 16 months (range, 3–63 months) in 12 patients with 43 PAVMs; three patients (7 PAVMs) were lost to follow-up.

Results

Immediate post-embolization angiography confirmed complete primary occlusion in 47 of 50 lesions (94%). Minor complications arose in two of 26 procedures (7.7%); they were abnormal electrocardiograms without symptoms during and pleurisy immediately after the procedure. During follow-up, 40 PAVMs were free of CT evidence of reperfusion. The mean partial arterial oxygen pressure increased from 75.3% ± 13.6 before embolization to 85.4% ± 16.3 after embolization ( P < 0.01, t-test). Of the 12 patients who were available for follow-up, none experienced new-onset paradoxical embolization; pre-treatment exertional dyspnea was alleviated in one patient. There were no major complications.

Conclusion

Venous sac embolization for PAVMs might be safe and more effective with no reperfusion than the standard pulmonary arterial embolization.
The prevalence and incidence of Systemic Lupus Erythematosus (SLE) in selected cities from three Commonwealth of Independent States countries (the Russian Federation, Ukraine and Kazakhstan)
Authors: Nasonov E , Soloviev S , Davidson JE , Lila A , Ivanova R , Togizbayev G , Omarbekova Z , Shevchuk S , Iaremenko O , Gnylorybov A , Smailova Z , Chernogolov V , Malynovska K , Vasylyev A , Pereira MHS
Published: November 2013

We assessed the prevalence and incidence of Systemic Lupus Erythematosus (SLE) in 2010 in adults from four cities in Russia, Kazakhstan and Ukraine. Individuals with SLE were identified retrospectively from the medical records of specialized centers. Prevalent SLE patients were nondeceased city residents, diagnosed prior to December 31, 2010; incident patients were residents newly diagnosed between January 1 and December 31, 2010. Population size was obtained from official census data.

The observed prevalence rates (per 100,000, 95% CI) were 9.0 (7.1–11.2) in Kursk and Yaroslavl, Russian Federation; 20.6 (15.4–27.0) in Semey, Kazakhstan; and 14.9 (10.9–19.9) in Vinnitsa, Ukraine. The cumulative incidence rates (per 100,000, 95% CI) were 1.4 (0.7–2.4); 1.6 (0.4–4.1) and 0.3 (0.0–1.8), correspondingly. All rates were higher among females compared to males, and incidence peaked in the population aged 25–44.

These rates appear slightly lower than those reported from Western Europe and the USA. This could be because of study design (case-ascertainment), local health care practices or true differences in disease risk. Case age and sex distribution was similar to the known epidemiology of SLE. The rates were highest in Kazakhstan, likely because of a predominantly ethnic Asian population.
Dysregulation of Inflammatory and Hemostatic Markers in Sepsis and Suspected Disseminated Intravascular Coagulation
Authors: Hoppensteadt Debra , Tsuruta Kazuhisa , Hirman Joe , Kaul Inder , Osawa Yutaka , Fareed Jawed
Published: November 2013

Inflammatory mediators and hemostatic markers were evaluated in patients enrolled in a phase-2b study evaluating the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with sepsis and suspected disseminated intravascular coagulation (DIC). In contrast to controls, patients with sepsis and suspected DIC showed an increase in the circulating levels of inflammatory and fibrinolytic markers. The levels of procalcitonin (PCT), interleukin 6 (IL-6), interleukin 10 (IL-10), anaphylatoxin C5a, plasminogen activator inhibitor 1 (PAI-1), and myeloperoxidase were higher in the patients with sepsis and suspected DIC, whereas protein C (PrC) exhibited a significant decrease. When the patients with overt and nonovert DIC were compared, the PrC level was lower, and PCT, PAI-1, IL-6, and IL-10 levels were higher in the patients with overt DIC. These results indicate that inflammation is elevated in sepsis and suspected DIC, and inflammation, impairment of fibrinolysis, and overconsumption of PrC may play a key role in the pathogenesis of DIC.
Modern Prescription Theory and Application: Realistic Expectations for Speech Recognition With Hearing Aids
Authors: Johnson Earl E.
Published: November 2013

A major decision at the time of hearing aid fitting and dispensing is the amount of amplification to provide listeners (both adult and pediatric populations) for the appropriate compensation of sensorineural hearing impairment across a range of frequencies (e.g., 160–10000 Hz) and input levels (e.g., 50–75 dB sound pressure level). This article describes modern prescription theory for hearing aids within the context of a risk versus return trade-off and efficient frontier analyses. The expected return of amplification recommendations (i.e., generic prescriptions such as National Acoustic Laboratories—Non-Linear 2, NAL-NL2, and Desired Sensation Level Multiple Input/Output, DSL m[i/o]) for the Speech Intelligibility Index (SII) and high-frequency audibility were traded against a potential risk (i.e., loudness). The modeled performance of each prescription was compared one with another and with the efficient frontier of normal hearing sensitivity (i.e., a reference point for the most return with the least risk). For the pediatric population, NAL-NL2 was more efficient for SII, while DSL m[i/o] was more efficient for high-frequency audibility. For the adult population, NAL-NL2 was more efficient for SII, while the two prescriptions were similar with regard to high-frequency audibility. In terms of absolute return (i.e., not considering the risk of loudness), however, DSL m[i/o] prescribed more outright high-frequency audibility than NAL-NL2 for either aged population, particularly, as hearing loss increased. Given the principles and demonstrated accuracy of desensitization (reduced utility of audibility with increasing hearing loss) observed at the group level, additional high-frequency audibility beyond that of NAL-NL2 is not expected to make further contributions to speech intelligibility (recognition) for the average listener.
The Labor Supply Effects of Taxing Social Security Benefits
Authors: Page Timothy F. , Conway Karen Smith
Published: November 2013

In 1983, federal and state governments began taxing the social security benefits of high-income elderly. We develop a conceptual model and use 1981–1986 Current Population Survey data to estimate the policy’s labor supply effects. Our estimates suggest that the approximate 20 percent reduction in benefits for the highest income individuals led to a two to five percentage point increase in their labor force participation. Using 2008 data, we show that failing to index the taxation thresholds for inflation, adding a second set of thresholds in 1993, and removing the earnings test in 2000 all substantially magnify the policy’s scope.
Secular trends in pupils’ assessments of physical education lessons in regard to their self-perception of physical fitness across the educational systems of Czech Republic and Poland
Authors: Frömel Karel , Vašíčková Jana , Svozil Zbyněk , Chmelík František , Skalik Krzysztof , Groffik Dorota
Published: November 2013

Observation of trends in physical education plays an integral role in motor-development diagnostics and in encouraging physical activity and a healthy lifestyle. This study aims to elucidate the current state of and trends in pupils’ assessments of physical education lessons (PELs) in different education systems in the context of self-perception of physical fitness. The research was conducted during PELs taught by student teachers at primary schools and high schools in the Czech Republic and in Poland. Schools were selected annually between 2000 and 2011 according to the student teachers’ places of residence. In total, the research involved 25,988 Czech pupils and 21,205 Polish pupils. At the end of each PEL, an anonymous questionnaire was distributed. The Czech and Polish versions contained cognitive, emotional, health, social, attitudinal, and creative dimensions and the supplementary dimension “pupil’s role”. For the analysis, pupils were divided according to their self-perceived physical fitness (SPF) as marked in the questionnaire (low or high). Polish and Czech pupils who evaluated themselves as having high physical fitness gave PELs higher evaluations, both overall and in individual dimensions, than those who evaluated themselves as having low physical fitness. During three 4-year periods between 2000 and 2011, a decline in positive PEL evaluations occurred in all groups, except among Polish girls with low SPF. A low positive-assessment rate was found in Czech girls with low SPF. The lowest rate was found in Czech boys with low SPF. The Polish system of education includes more weekly PEL and offers vocational training for PE teachers, facilitating more positive evaluation of PEL by pupils compared with the Czech system. It is necessary to focus on meeting the needs of pupils with low SPF during teacher training and in teaching.
“Bill is now singing”: Joint engagement and the emergence of social communication of three young children with autism
Authors: Vaiouli Potheini , Grimmet Kharon , Ruich Lawrence J
Published: November 2013

Young children with autism spectrum disorder meet significant challenges in joint attention skills and in social communication. A child-centered, improvisational, music therapy intervention model was implemented to promote engagement in three young children with autism in a kindergarten classroom. A multiple baseline design compared the children’s performance through three phases of intervention: focus on faces, response to joint attention, and initiation of joint attention. A complimentary qualitative analysis of teacher and parent experiences allowed for an in-depth understanding of the role of social environment in supporting emerging social communication skills among three children. As all children showed improvement in joint attention and actions of social engagement, this study bears evidence on the potential of music therapy as a promising intervention for promoting social skills of young children with autism spectrum disorder.
Factors influencing principals’ retirement decisions
Authors: Reames Ellen H. , Kochan Frances K , Zhu Linxiang
Published: November 2013

This study, conducted in one state in the United States, replicated similar research from over a decade ago to compare principal demographics and reasons for remaining or leaving the profession. Demographics have trended with the nation. Principals are older, more diverse and are largely eligible for retirement within the next five years. Similar demographics are noted in Australia, New Zealand and the United Kingdom. The reasons for retiring have changed dramatically since the first survey. External mandates were the number one reason for retirement. Another reason included spending more time with their family. Around the globe, other countries are considering national initiatives, such as accountability and high-stakes testing or national curriculum standards. This study may provide a cautionary note regarding the impact on principal role and retention. Thus, while the study occurred in the United States, the policies that influenced principals’ reasons for choosing to retire or stay in the profession appear to have global implications.
A review of the use of magnetic resonance imaging in Parkinson’s disease
Authors: Pyatigorskaya Nadya , Gallea Cécile , Garcia-Lorenzo Daniel , Vidailhet Marie , Lehericy Stéphane
Published: November 2013

To date, the most frequently used Parkinson’s disease (PD) biomarkers are the brain imaging measures of dopaminergic dysfunction using positron emission tomography and single photon emission computed tomography. However, major advances have occurred in the development of magnetic resonance imaging (MRI) biomarkers for PD in the past decade. Although conventional structural imaging remains normal in PD, advanced techniques have shown changes in the substantia nigra and the cortex. The most well-developed MRI markers in PD include diffusion imaging and iron load using T2/T2* relaxometry techniques. Other quantitative biomarkers such as susceptibility-weighted imaging for iron load, magnetization transfer and ultra-high-field MRI have shown great potential. More sophisticated techniques such as tractography and resting state functional connectivity give access to anatomical and functional connectivity changes in the brain, respectively. Brain perfusion can be assessed using non-contrast-agent techniques such as arterial spin labelling and spectroscopy gives access to metabolites concentrations. However, to date these techniques are not yet fully validated and standardized quantitative metrics for PD are still lacking. This review presents an overview of new structural, perfusion, metabolic and anatomo-functional connectivity biomarkers, their use in PD and their potential applications to improve the clinical diagnosis of Parkinsonian syndromes and the quality of clinical trials.
Elevated international normalized ratio with the consumption of grapefruit and use of warfarin
Authors: Bodiford Andrew B , Kessler Fred O , Fermo Joli D , Ragucci Kelly R
Published: November 2013

A 65-year-old male with documented atrial flutter who was taking warfarin chronically returned to the anticoagulation clinic for follow-up, after having been on 10 mg daily for approximately 2 weeks. He had a previous sub-therapeutic international normalized ratio of 1.7 on a dose of 65 mg/week. The international normalized ratio at this visit was now 4.77 via venipuncture, after just an 8% increase in weekly dosing. He self-reported adherence to the new warfarin dosing but had begun eating grapefruit since last visit. The patient had no active bleeding and was told to decrease his dose to 8 mg daily. He also stopped eating the grapefruit. One week later, he returned to the clinic and the international normalized ratio was 2.1. He is currently back on warfarin 65 mg/week, and his international normalized ratio has been within therapeutic range for the past 4 months. Clinicians should have a heightened awareness of the potential for elevated international normalized ratio when grapefruit juice is consumed in a patient who is taking warfarin.
Critical Beliefs Underlying Young Australian Males’ Intentions to Engage in Drinking and Swimming
Authors: Hamilton Kyra , Schmidt Hannah
Published: November 2013

This study examined key targets for interventions aimed at reducing drinking and swimming among young males, an at-risk group for drowning. Two-hundred and eleven Australian males aged 18 to 34 years completed a Theory of Planned Behavior belief-based questionnaire either online or paper based. Behavioral beliefs of “be more relaxed” and “having fun,” normative beliefs of “friends/mates” and “parents,” and the control belief of “presence of other people” were revealed as independent predictors of intentions to drink and swim. These identified beliefs can be used to inform interventions to challenge young males’ alcohol use in, on, and around water.
An Exploratory Examination of Social Ties and Crime in Mobile Home Communities
Authors: McCarty William P.
Published: November 2013

Guided by the systemic model of social disorganization, the purpose of this study was to explore the nature of social ties in mobile home communities and examine how that relates to rates of violent and property crime. Interviews with a small sample of mobile home residents, owners, and managers in Omaha, Nebraska, indicate a wide spectrum of communities, from those characterized by an atomized population to those with strong social ties. Fear of crime, ethnically heterogeneous populations, and lax management were cited by respondents as factors that undermined relationships. Proactive management and a desire to help neighbors were cited by respondents as factors that helped strengthen relationships. Violent and property crime rates for the mobile home communities were largely consistent with the interview data, providing support for the importance of social networks and a systemic model of social disorganization. The implications of these findings for research and policy are also explored.
High expression of astrocyte elevated gene-1 (AEG-1) is associated with progression of cervical intraepithelial neoplasia and unfavorable prognosis in cervical cancer
Authors: Huang Ke , Li Li An , Meng Yuanguang , You Yanqin , Fu Xiaoyu , Song Lei
Published: November 2013

Background

Astrocyte elevated gene-1(AEG-1) plays an important role in the development and progression of certain types of human cancers. However, the expression dynamics of AEG-1 in cervical cancer and its clinical/prognostic significance are unclear.

Method

In present study, the methods of tissue microarrays (TMA) and immunohistochemistry (IHC) were utilized to investigate AEG-1 expression in cervical intraepithelial neoplasia (CIN) and cervical cancer. Receiver operating characteristic (ROC) curve analysis, χ 2 test, Kaplan-Meier plots, and multivariate Cox regression analysis were used to analyze the data.

Results

The expression level of AEG-1 was increased from CIN I to CIN III. High expression of AEG-1 could be observed in 61.1% (55/90) of cervical cancer. Moreover, high expression of AEG-1 correlated with tumor size and lymph node metastasis (all P <0.05). More importantly, high expression of AEG-1 was closely associated with cervical cancer patient shortened survival time as evidenced by univariate and multivariate analysis (P <0.05).

Conclusions

Our data suggest for the first time that high expression of AEG-1 is associated significantly with progression of cervical cancer. AEG-1 overexpression, as examined by IHC, has the potential to be used as an immunomarker to predict prognosis of cervical cancer patients.
Diversity and genetics of nitrogen-induced susceptibility to the blast fungus in rice and wheat
Authors: Ballini Elsa , Nguyen ThuyThu Thi , Morel Jean-Benoit
Published: November 2013

Background

Nitrogen often increases disease susceptibility, a phenomenon that can be observed under controlled conditions and called NIS, for Nitrogen-Induced Susceptibility. NIS has long been reported in the case of rice blast disease caused by the fungus Magnaporthe oryzae. We used an experimental system that does not strongly affect plant development to address the question of NIS polymorphism across rice diversity and further explored this phenomenon in wheat. We tested the two major types of resistance, namely quantitative/partial resistance and resistance driven by known resistance genes. Indeed there are conflicting reports on the effects of NIS on the first one and none on the last one. Finally, the genetics of NIS is not well documented and only few loci have been identified that may control this phenomenon.

Results

Our data indicate that NIS is a general phenomenon affecting resistance to blast fungus in these two cereals. We show that the capacity of rice to display NIS is highly polymorphic and does not correlate with difference related to indica/japonica sub-groups. We also tested the robustness of three different major resistance genes under high nitrogen. Nitrogen partially breaks down resistance triggered by the Pi1 gene. Cytological examination indicates that penetration rate is not affected by high nitrogen whereas growth of the fungus is increased inside the plant. Using the CSSL mapping population between Nipponbare and Kasalath, we identified a Kasalath locus on chromosome 1, called NIS1, which dominantly increases susceptibility under high nitrogen. We discuss the possible relationships between Nitrogen Use Efficiency (NUE), disease resistance regulation and NIS.

Conclusions

This work provides evidences that robust forms of partial resistance exist across diversity and can be easily identified with our protocol. This work also suggests that under certain environmental circumstances, complete resistance may breakdown, irrelevantly of the capacity of the fungus to mutate. These aspects should be considered while breeding for robust forms of resistance to blast disease.
An employee transporting problem
Authors: Yüceer Ümit
Published: November 2013

An employee transporting problem is described and a set partitioning model is developed. An investigation of the model leads to a knapsack problem as a surrogate problem. Finding a partition corresponding to the knapsack problem provides a solution to the problem. An exact algorithm is proposed to obtain a partition (subset-vehicle combination) corresponding to the knapsack solution. It requires testing and matching too many alternatives to obtain a partition. The sweep algorithm is implemented in obtaining a partition (subset-vehicle combination) in an efficient manner. Illustrations are provided to show how the algorithms obtain solutions.
Stable assembly of HIV-1 export complexes occurs cotranscriptionally
Authors: Nawroth Isabel , Mueller Florian , Basyuk Eugenia , Beerens Nancy , Rahbek Ulrik L. , Darzacq Xavier , Bertrand Edouard , Kjems Jørgen , Schmidt Ute
Published: November 2013

The HIV-1 Rev protein mediates export of unspliced and singly spliced viral transcripts by binding to the Rev response element (RRE) and recruiting the cellular export factor CRM1. Here, we investigated the recruitment of Rev to the transcription sites of HIV-1 reporters that splice either post- or cotranscriptionally. In both cases, we observed that Rev localized to the transcription sites of the reporters and recruited CRM1. Rev and CRM1 remained at the reporter transcription sites when cells were treated with the splicing inhibitor Spliceostatin A (SSA), showing that the proteins associate with RNA prior to or during early spliceosome assembly. Fluorescence recovery after photobleaching (FRAP) revealed that Rev and CRM1 have similar kinetics as the HIV-1 RNA, indicating that Rev, CRM1, and RRE-containing RNAs are released from the site of transcription in one single export complex. These results suggest that cotranscriptional formation of a stable export complex serves as a means to ensure efficient export of unspliced viral RNAs.
Generating tacit knowledge through motion: A vision on the matter of space
Authors: Vroman Liselotte , Naveda Luiz , Leman Marc , Thierry Lagrange
Published: November 2013

This article aims to deepen our understanding of the embodied experience of space by means of observation and explorative analysis of how an individual interacts with space through movement. We focus on how architecture can be conceived by considering the embodied experience of space.
We look at the level of spatial awareness and expression of the movements reached in dance. Architectural boundaries are explored by means of empirical methods. The subject experiences space, but can this embodied experience be handled and moulded by the architect, the so-called designer of
spaces? Movements can be considered as expressions derived from the embodied experience in a particular space. Techniques of movement analysis were used in an attempt to capture this embodied experience through motion. Can the results of this assumption contribute to design-based architectural
thinking by understanding the outcome of tacit knowledge gained from spatial visualizations? This is an ongoing research project, and thus this article describes a work in progress. The goal comprises the development of an architectural implementation with regard to the embodied experience
of space in design.
Federal targeted programme 'Prevention and Management of Socially Significant Diseases (2007-2012)': results of the 'Diabetes mellitus' sub-programme
Authors: Dedov Ivan Ivanovich , Shestakova Marina Vladimirovna , Suntsov Yury Ivanovich , Peterkova Valentina Alexandrovna , Galstyan Gagik Radikovich , Mayorov Alexander Yuryevich , Kuraeva Tamara Leonidovna , Sukhareva Olga Yur'evna
Published: November 2013

During 2007-2012 years the ?Diabetes mellitus? sub-programme reached the performance targets with the following results. Development of the State Diabetes Register covering all regions of the Russian Federation. The Register facilitates the continuous evaluation and planning of diabetes care in this country, analysis of epidemiological dynamics (including incidence and mortality in diabetes population) and human resources management.Alteration of the demographics of the national diabetes population, specifically: - an increase in life expectancy among T1DM patients: up to 56.7 years (+3.8 years) in males and up to 60.8 years (+4.1 years) in females; an increase in life expectancy among T2DM patients: up to 72.4 years (+3.2 years) in males and up to 74.5 years (+2.9 years) in females; - a reduction in mortality of diabetes patients for 28.4%; Introduction of novel technologies for diagnostics, prevention and management of DM and its complications, that, in turn, allowed to: - decrease the incidence of diabetic nephropathy for 16.1% and extend the pre-dialysis period; - decrease the incidence of diabetic retinopathy for 11.4% and preserve vision in 86-91% patients who still develop this complication; - decrease the frequency of upper- and lower-level amputations for 24% and 28%, respectively, and to reduce the ulcer healing times 2.5 to 3-fold;Introduction of safe and highly efficient human recombinant insulin and its analogues in the regions of the Russian Federation, along with modern methods of insulin administration and outpatient blood glucose monitoring.Establishment of diabetes educational centres (more than 1100 in the regions of the Russian Federation) that resulted in substantial reduction of number and frequency of diabetes-associated hospital admissions.The sub-programme is estimated to have saved 6 727 596.9 thousand Russian rubles of the budgetary funds due to decrease in the incidence of microvascular complications. A total of 360 papers (including 35 in international medical journals), as well as 81 clinical guidance manuals and 23 monographs were published during the course of this sub-programme.
The relationship between gestational weight gain and fetal growth: time to take stock?
Authors: O’Higgins Amy C. , Doolan Anne , Mullaney Laura , Daly Niamh , McCartney Daniel , Turner Michael J.
Published: November 2013

The aim of this article is to review the current evidence on gestational weight gain (GWG). Maternal obesity has emerged as one of the great challenges in modern obstetrics as it is becoming increasingly common and is associated with increased maternal and fetal complications. There has been an upsurge of interest in GWG with an emphasis on the relationship between excessive GWG and increased fetal growth. Recent recommendations from the Institute of Medicine in the USA have revised downwards the weight gain recommendations in pregnancy for obese mothers. We believe that it is time to take stock again about the advice that pregnant women are given about GWG and their lifestyle before, during, and after pregnancy. The epidemiological links between excessive GWG and aberrant fetal growth are weak, particularly in obese women. There is little evidence that intervention studies decrease excessive GWG or improve intrauterine fetal growth. Indeed, there is a potential risk that inappropriate interventions during the course of pregnancy may lead to fetal malnutrition that may have adverse clinical consequences, both in the short- and long-term. It may be more appropriate to shift the focus of attention from monitoring maternal weight to increasing physical activity levels and improving nutritional intakes.
Relation of placental diagnosis in stillbirth to fetal maceration and gestational age at delivery
Authors: Stanek Jerzy , Biesiada Jacek
Published: November 2013

Aim: To study the relation of retention of dead fetus resulting in its maceration and gestational age at delivery to placental diagnosis.

Methods: Some 75 clinicoplacental phenotypes have been retrospectively analyzed in 520 consecutive stillbirths, 329 macerated and 191 nonmacerated, and at three gestational age interval cohorts (330 second trimester, 102 preterm third trimester, and 88 term). Chi-square and clustering methods (Ward dendrograms and multidimensional scaling) were used for statistical analysis.

Results: Maternal diabetes mellitus, induction of labor, fetal growth restriction, various umbilical cord abnormalities, and placental clusters of sclerotic/hemosiderotic chorionic villi were more common in macerated stillbirths, while clinicoplacental signs and symptoms of ascending infection and placental abruption, i.e., retroplacental hematoma, premature rupture of membranes, and acute chorioamnionitis in nonmacerated stillbirths. Placental abnormalities were less common in the second trimester, other than the acute chorioamnionitis. Patterns of chronic hypoxic placental injury were common in preterm third trimester, while signs of in-utero hypoxia (abnormal cardiotocography, meconium, and histological erythroblastosis of fetal blood) in term pregnancy. In addition to classical statistics, the clustering analyses added new information to placental investigation of cause of stillbirth.

Conclusions: Macerated third trimester stillbirths have multifactorial etiology more likely than the second trimester stillbirths and the likely stasis-induced fetal thrombotic vasculopathy secondary to occult umbilical cord compromise should be sought in placental investigation in such cases. Nonmacerated stillbirths are associated with ascending infection and placental abruption.
Influência do ambiente no conteúdo calórico e na condição fisiológica de duas espécies migradoras de peixes neotropicais
Authors: Pazianoto Laryssa H. R. , Souza Maíra L. S. , Veronezzi Ana Lúcia , Benedito Evanilde
Published: November 2013

O presente estudo teve por objetivo determinar o conteúdo calórico e fator de condição de uma espécie de peixe iliófaga e outra piscívora, na planície de inundação do alto rio Paraná, e suas possíveis diferenças sazonais e temporais. As espécies foram amostradas entre junho de 2010 e março de 2011 e, dos indivíduos que se apresentaram no estádio de desenvolvimento gonadal em repouso, extraíram-se músculos próximos à nadadeira dorsal, os quais foram enxaguados em água destilada, e secos a 60°C. Posteriormente, foram macerados e queimados em bomba calorimétrica. Em relação aos subsistemas, a densidade energética e o fator de condição apresentaram diferenças significativas apenas para Prochilodus lineatus (Valenciennes, 1837), com os maiores valores constatados no subsistema Ivinhema para as duas análises. Nas análises por tipo de ambiente não foram encontradas diferenças significativas para nenhuma das espécies, tanto para densidade energética, quanto para fator de condição. Em relação ao ciclo hidrológico, foram registradas diferenças significativas para a densidade energética e fator de condição de Pseudoplatystoma corruscans (Spix & Agassiz, 1829), com os maiores valores para o mês de setembro e março, respectivamente. Apesar das análises para Prochilodus lineatus não terem apresentado diferenças significativas, constataram-se os maiores valores de densidade energética e fator de condição para o mês de junho, indicando a possível influência do ciclo hidrológico no período reprodutivo das referidas espécies. Assim, conclui-se que a densidade energética e o fator de condição dos peixes podem sofrer variações sazonais e temporais, de acordo com o ambiente analisado e o ciclo hidrológico.
Uso do espaço por Lontra longicaudis (Mustelidae, Carnivora) em ambiente alterado no rio Caí, Rio Grande do Sul, Brasil
Authors: Coletti Luciane D. , Michel Thaís , Sanfelice Daniela , Jardim Márcia M. A.
Published: November 2013

A utilização de abrigos e do espaço pela lontra neotropical (Lontra longicaudis) (Olfers, 1818), foi estudada em um ambiente alterado e com presença humana no rio Caí, Triunfo, RS. A maioria dos sítios de marcação teve uso ocasional, e uma pequena percentagem teve uso frequente e intenso. A maioria das marcações de cheiro se encontrava no solo a uma média de distância de 1,65m da linha d'água. Ao todo foram encontrados sete abrigos na área de estudo, sendo que a lontra demonstrou preferência por abrigos específicos. O abrigo mais utilizado se constituía em escavações na barranca do rio sob as raízes de uma árvore, sendo este o de maiores dimensões e o único com galerias sob o solo. Os demais abrigos se encontravam no nível do solo e consistiam em emaranhados de galhos sob a vegetação, ou de raízes e/ou troncos caídos. O uso do espaço pela lontra esteve correlacionado à localização de suas tocas, ao grau de cobertura vegetal do local e parece ter sido pouco influenciado pelo distúrbio humano. Para medidas de conservação da lontra neotropical ressalta-se a importância da manutenção da mata ciliar e a proteção das áreas com a presença de abrigos.
Ostracoda (Crustacea) from the Archipelago of São Pedro and São Paulo, Equatorial Atlantic, with emphasis on a new Hemicytheridae genus
Authors: Coimbra João C. , Bottezini Silvia R. , Machado Cláudia P.
Published: November 2013

The present study is a further contribution to the systematic knowledge of the shallow water marine ostracodes from the Brazilian oceanic islands. A total of 14 species belonging to 10 genera and eight families is herein identified. One new genus and species are described and illustrated: Berguecythere insularis gen. nov., sp. nov. In addition to this new taxon, the abundant species Loxocorniculum tricornatum Krutak, 1971, widely distributed in recent sediments in the Gulf of Mexico, Caribbean, north and northeast of Brazil and the Rocas Atoll, along with the cosmopolitan tropical ostracode Triebelina sertata Triebel, 1948, were also identified at specific level. The remaining 11 species were left at the genus level, and should provide new species. Ecological, zoo- and paleozoogeographical aspects were also briefly discussed.
Resolutividade na atenção à saúde da criança: percepção de pais e cuidadores
Authors: Silva Rosane Meire Munhak da , Viera Cláudia Silveira , Toso Beatriz Rosana Gonçalves de Oliveira , Neves Eliane Tatsch , Rodrigues Rosa Maria
Published: November 2013

OBJETIVO: Compreender como ocorre a resolutividade do problema de saúde do filho na visão de pais e cuidadores, a partir dos atributos da atenção primária à saúde. MÉTODOS: Pesquisa qualitativa com abordagem hermenêutico-dialética, envolvendo 16 cuidadores de crianças menores de um ano, atendidas em serviços de pronto atendimento. RESULTADOS: Falta de acesso, ausência de vínculo e coordenação, privação do cuidado integral contribui para não resolutividade, levando a busca por soluções alternativas para resolver os problemas de saúde das crianças. CONCLUSÃO: Na apreensão do estudo observa-se que os serviços de atenção primária não se mostram resolutivos diante dos problemas de saúde das crianças, visto que, os atributos essenciais para efetividade nesse ponto de atenção não estiveram presentes.
Prevalência de violência por parceiro íntimo relatada por puérperas
Authors: Marcacine Karla Oliveira , Abuchaim Érika de Sá Vieira , Abrahão Anelise Riedel , Michelone Cecília de Souza Lima , Abrão Ana Cristina Freitas de Vilhena
Published: November 2013

OBJETIVOS: Estimar a prevalência de violência por parceiro íntimo relatada puérperas, classificar o tipo de violência, o período do ciclo gravídico puerperal na ocorrência e caracterizar o perfil do companheiro. MÉTODOS: Estudo transversal realizado com 207 puérperas. O instrumento de pesquisa utilizado foi baseado no modelo proposto por Schraiberet. RESULTADOS: A prevalência de violência por parceiro íntimo antes, durante e/ou depois da gestação foi de 51,2%. O perfil do companheiro foi caracterizado como um grupo jovem, com boa escolaridade, trabalhador, não usuários de drogas lícitas e ilícitas. CONCLUSÃO: A prevalência da ocorrência de violência por parceiro íntimo relatado por puérperas foi de 51,2%.
Endoscópio rígido e flexível na sinoscopia e técnica de triangulação em seios paranasais de equinos
Authors: Machado Thaís Sodré de Lima , Silva Luís Cláudio Lopes Correia da
Published: November 2013

A endoscopia dos seios paranasais, denominada sinoscopia, trata-se de técnica minimamente invasiva efetiva para diagnóstico e tratamento das afecções sinusais. Este trabalho teve como objetivo determinar portais para triangulação, a partir dos pontos de sinoscopia já descritos e comparar a utilização de endoscópio rígido e flexível de pequeno calibre durante a sinoscopia em equinos de diferentes idades. Foram realizados, sequencialmente três procedimentos: sinoscopia com endoscópio rígido, sinoscopia com endoscópio flexível e abordagem cirúrgica por técnica de triangulação. A qualidade da imagem obtida com o endoscópio rígido foi superior à do endoscópio flexível, entretanto, a amplitude de visão foi maior com o endoscópio flexível, que permitiu maior mobilidade e aproximação das estruturas anatômicas dos seios paranasais. A partir dos portais situados sobre o seio frontal, foi possível examinar tanto o seio frontal como o maxilar caudal. Através do portal do seio maxilar caudal, foram examinadas as raízes dentárias e demais estruturas localizadas no interior deste. O exame do seio maxilar rostral foi dificultado em alguns casos devido ao acentuado tamanho da raiz do 1°dente molar, principalmente em animais jovens. Os portais para técnica de triangulação foram determinados nos seios frontal e maxilar caudal, permitindo acesso de instrumental cirúrgico às estruturas anatômicas. Através dos resultados obtidos foi possível estabelecer portais para realização de técnicas de sinoscopia e triangulação no diagnóstico e tratamento das afecções sinusais de equinos, utilizando endoscópio rígido ou flexível.
Perfil bioquímico e capacidade antioxidante total em cavalos de polo suplementados com selênio e vitamina-E
Authors: Vieira Waldsylvio Silva , Rodrigues Isabella Manes Soutto Mayor da Motta , Frade Natália Pereira Lopes , Baldani Cristiane Divan , Botteon Rita de Cassia Campbell Machado , Botteon Paulo de Tarso Landgraf
Published: November 2013

O objetivo deste trabalho foi avaliar as alterações bioquímicas e da capacidade antioxidante total (CAT) em cavalos de pólo, e o efeito da suplementação de selênio (Se) e vitamina E (Vit-E) sobre esses parâmetros. Dezesseis equinos aleatoriamente divididos em dois grupos, GE/Se (suplementados com Vit-E e Se) e GC (grupo controle), participaram de um jogo de polo com quatro períodos (chukkas) de 7 minutos. Cada cavalo competiu em dois chukkas, com 7minutos de intervalo. Amostras de sangue foram colhidas 15min antes do jogo (basal), ao final do 1° e 2° chukkas e 24h, 48h e 72h após o término da competição. Foram analisadas as atividades séricas da aspartato aminotrasferase (AST) , creatinoquinase (CK) e lactato desidrogenase (LDH), a glicemia e lactatemia e a capacidade antioxidante total (CAT). Os valores de aspartato aminotrasferase, creatinoquinase e lactato desidrogenase não apresentaram diferenças significativas entre o GE/Se e o GC. A atividade de AST e LDH aumentou significativamente em relação ao valor basal (P=0,097) e (P=0,0002), respectivamente, e permaneceram elevadas por mais tempo no GC. A CK não apresentou variações significativas em relação ao basal em ambos os grupos. A lactatemia aumentou significativamente após cada chukka, comparada ao basal e foi maior no GC que no GE/Se após o primeiro chukka (P<0,05). A CAT foi significativamente menor (P=2,90-25) após o primeiro chukka, retornando aos valores basais após 24 horas, porém sem diferença entre os grupos. Conclui-se que a suplementação com vit-E e Se não influencia nos parâmetros avaliados. O exercício alterou o perfil bioquímico e a CAT sem causar lesões, sugerindo um bom condicionamento físico e adequada proteção antioxidante nos animais estudados.
Estudo bioclimático das regiões litorânea, agreste e semiárida do estado de Sergipe para a avicultura de corte e postura
Authors: Santos Gleicianny de Brito , Sousa Inajá Francisco de , Brito Claudson Oliveira , Santos Vanicleide da Silva , Barbosa Rosylaine de Jesus , Soares Claudineide
Published: November 2013

Objetivou-se com o presente trabalho realizar o estudo bioclimático do estado de Sergipe para a avicultura, como forma de definir os limites de aceitabilidade da espécie às condições ambientais prevalecentes nas regiões litorânea, agreste e semiárida do estado. Para isso, foi realizado o levantamento histórico dos valores médios mensais de temperatura e umidade relativa do ar e o cálculo mensal do índice de temperatura e umidade (ITU) das três regiões do estado de Sergipe. Verificou-se que, apesar de suas particularidades climáticas, as regiões litorânea, agreste e semiárida do estado de Sergipe apresentam as melhores condições de conforto térmico para a avicultura de corte e postura apenas durante os meses de junho a setembro; no período seco, nenhuma das regiões apresenta condições de conforto térmico para a atividade avícola; no período chuvoso, apenas a região agreste apresenta condições de conforto para a avicultura de corte; para a avicultura de postura, apenas a região litorânea não apresenta condições de conforto térmico.
Avaliação da incorporação de resíduo de gemas na massa cerâmica vermelha: um estudo de caso
Authors: Weizenmann M. , Bruxel F. R. , Santana E. R. R. de , Oliveira E. C.
Published: November 2013

Ao longo dos últimos anos algumas preocupações ambientais tem se ressaltado, é o caso da contínua utilização de recursos naturais não renováveis bem como a geração de resíduos dos mais diversos segmentos. Felizmente, há possibilidade de empregar resíduos, por exemplo, como aditivos na indústria cerâmica. O objetivo deste trabalho é avaliar a viabilidade técnica da incorporação do resíduo de corte de gemas na fabricação de tijolos, comparando a outro trabalho desenvolvido no mesmo município. Foram produzidos cento e cinquenta corpos de prova com as concentrações de 0%, 2%, 6%, 10% e 14% (m/m) de resíduo na argila. Os resultados obtidos após os testes de absorção de água, massa específica aparente e resistência à compressão revelaram que é possível a utilização de até 2% do resíduo do corte de gemas junto à massa argilosa.