bluuebunny/crossref_metadata_2025 huggingface dataset:
Depresión en el Perú: revisión bibliométrica
Authors:   , Ramirez Olivera Santos Arturo , Rivasplata Vasquez Gonzalo Daniel
Published: November 2022

Objetivo: Evaluar la producción científica de la depresión en el Perú durante el período 1980-2020. Materiales y métodos: Estudio bibliométrico de artículos de investigación sobre depresión realizado en Perú. Se buscaron artículos indexados en PUBMED, SCOPUS y SCIELO desde 1980 hasta 2020 y posteriormente se analizaron en Microsoft Excel 2016 y el programa VOSviewer 1.6.18. Los criterios de inclusión fueron artículos originales, revisiones, reportes de casos, ensayos, estudios con poblaciones que pudieran distinguir a la población peruana. Resultados: inicialmente se encontraron 1669 documentos en PUBMED, SCOPUS y SCIELO, de los cuales solo 171 cumplieron con los criterios de inclusión, siendo aparentemente la mayor afiliación la Universidad Peruana Cayetano Heredia, con 29 autores y la Universidad Peruana de Ciencias Aplicadas tiene 13 autores, de los cuales las instituciones más extranjeras son la Universidad de Harvard con 13 autores y King's College con 8 autores. En cuanto a la producción de artículos, encontramos que la institución nacional con mayor producción fue la Universidad Peruana Cayetano Heredia, con 26 artículos, y la institución con mayor producción en el extranjero, la Universidad de Harvard, con 17 artículos. El año con mayor número de artículos fue el 2020 con 38 documentos, seguido del 2019 con 23 documentos y el 2017 con 16 documentos. Conclusiones: Se concluyó que la producción científica de la depresión ha crecido exponencialmente en los últimos años, pero la investigación con respecto a otras patologías clínicas sigue siendo escasa a nivel nacional e internacional.
Comparación del efecto antibacteriano del extracto acuoso y alcohólico de hojas secas de Erythroxylum coca "Coca" frente a Streptococcus mutans ATCC®35668™ y Lactobacillus acidophilus ATCC®4356™
Authors:   , Cossio Alva Bryan Alexis
Published: November 2022

Introducción: La hoja de Erythroxylum coca, se utiliza tradicionalmente en diversos países por sus bondades farmacológicas. Objetivo: Comparar el efecto antibacteriano del extracto acuoso y alcohólico de hojas de Erythroxylum coca frente a Streptococcus mutans ATCC®35668™ y Lactobacillus acidophilus ATCC®4356™. Métodos: Estudio experimental in vitro. Se obtuvo el extracto acuoso y alcohólico de E. coca. La muestra estuvo conformada por 20 placas petri para cada concentración y extracto evaluado. La media de los diámetros de los halos de inhibición, se expresaron en milímetros y se analizaron mediante la prueba de Kruskal-Wallis y el análisis post hoc de Dunn con ajuste de Bonferroni. La comparación de los efectos entre las 24 y 48 horas se realizó mediante el test Wilcoxon con un nivel de significancia del 5 %. Resultados: La concentración alcohólica de 25 mg/mL fue más efectiva sobre S. mutans, al compararla con los otros grupos (p< 0,05). En el extracto alcohólico se observó diferencias con la concentración de 50 mg/mL a las 24 y 48 horas frente a S. mutans (p< 0,05). Se observaron diferencias significativas al comparar el efecto inhibitorio del extracto acuoso de 75 mg/mL y 50 mg/mL a las 24 y 48 horas frente a L. acidophilus (p< 0,05) y para el extracto alcohólico las diferencias fueron estadísticamente significativas con las concentraciones de 50 mg/mL y 25 mg/mL (p< 0,05). Conclusión: Existen diferencias en el efecto antibacteriano del extracto acuoso y alcohólico de las hojas de E. coca frente a S. mutans y L. acidophilus.
Fuzzy Logic Simulations for a Smart Air Conditioning System
Authors: K RAJA , Ramathilagam S
Published: November 2022

The temperature control, fan speed, and other features of the air conditioning system we use every day are all manually automated. Recent air conditioners offer automatic temperature control, variable fan speed, variable compressor speed, and more. However, using a Fully Logic Control System, we have refined it in this study to move automation one step further ahead. We count the number of people in the room using an IR sensor, and the temperature and fan speed are then adjusted accordingly. We estimate the room's size using sonar, and based on this data, we determine the fin's tilt position and maintain fan speed. We determine the inside temperature using an external temperature and humidity sensor. These are the three variables or ways by which we calculate the temperature, fan speed, and fin direction necessary to maintain the desired temperature.
The Effects of Parity on Duration of Exclusive Breastfeeding in Kilimanjaro Region, Tanzania – A Prospective Cohort Study
Authors: George Johnston Mukiza , Mgongo Melina , Rie Annelies Van
Published: November 2022

Background:Breastfeeding is essential for a child’s healthy growth and development. The World Health Organization recommends early inhiation and six months of continuation of exclusive breastfeeding (EBF). Parity might influence EBF uptake, but it remains unclear how previous breastfeeding duration affects subsequent children's breastfeeding duration among multiparous women.
Methods: Secondary data analysis of a prospective cohort of pregnant women (third trimester) and their infant (followed until age 12 months) enrolled from 2002-2015 in Kilimanjaro-Tanzania. In this analysis, eligible mothers were multipara women who entered the study as primigravida. To evaluate how parity affects EBF duration, Kaplan-Meier survival curves and multivariate Cox-proportional hazard models were applied.
Results: Only 56.3% of children-initiated breastfeeding within one hour of birth. Early initiation of breastfeeding did not differ between firstborn and subsequent-born children (p=0.88) and did not change over time. While 69% of women practiced EBF for three months, only 5% did so for 6 months. The proportion of children receiving EBF for the recommended 6 months rose from 3.2% for firstborns to 5.1% for second-borns, 9.6%, for third-borns and 15.8% for fifth-borns. The mean EBF duration increased from 11.1 weeks in 2000/2005 to 15.0 weeks in 2011/2015, corresponding to 87% higher hazards for longer EBF (aHR: 1.87 95%CI: 1.32-2.63) for children born between 2011 and 2015 compared to those born between 2000 and 2005. Children born to mothers with medium and high SES had 31% (aHR: 1.31 95%CI: 1.10-1.56) and 23% (aHR:1.23 95%CI: 1.00-1.54) higher hazards for prolonged EBF compared to children born to mothers with low SES. Compared to those women who delivered at home, children delivered in health facilities had 22% greater hazards for longer EBF (aHR: 1.22 95%CI: 1.01-1.52).
Conclusion: In this study in Tanzania, an unacceptable low proportion of women completed 6 months EBF, but parity was not independently associated with EBF duration for multiparous women. The increase in EBF duration between 2000 and 2015 shows that EBF is responsive to policy changes and public health efforts. EBF counselling should be improved, especially for women of poor SES and women who deliver at home.
LCK Facilitates DNA Damage Repair by Stabilizing RAD51 and BRCA1 in the Nucleus of Chemoresistant Ovarian Cancer
Authors: Reizes Ofer , DEY GOUTAM , BHARTI RASHMI , Braley Chad , Alluri Ravi , Esakov Emily , Crean-Tate Katie , McCrae Keith , Joehlin-Price Amy , Rose Peter , Lathia Justin , Gong Zihua
Published: November 2022

Poly-ADP Ribose Polymerase (PARP) targeted therapy is clinically approved for the treatment of homologous recombination (HR) repair deficient tumors. The remarkable success of this therapy in the treatment of HR repair deficient cancers has not translated to HR-proficient cancers. Our studies identify the novel role of non-receptor lymphocyte-specific protein tyrosine kinase (LCK) in the regulation of HR repair in endometrioid epithelial ovarian cancer (eEOC) model. We show that DNA damage leads to direct interaction of LCK with the HR repair proteins RAD51 and BRCA1 in a kinase dependent manner RAD51 and BRCA1 stabilization. LCK expression is induced and activated in the nucleus in response to DNA damage insult. Disruption of LCK expression attenuates RAD51, BRCA1, and BRCA2 protein expression by hampering there stability and results in inhibition of HR-mediated DNA repair including suppression of RAD51 foci formation, and augmentation of gH2AX foci formation. In contrast LCK overexpression leads to increased RAD51 and BRCA1 expression with a concomitant increase in HR DNA damage repair. Importantly, attenuation of LCK sensitizes HR-proficient eEOC cells to PARP inhibitor in cells and pre-clinical mouse studies. Collectively, our findings identify a novel therapeutic strategy to expand the utility of PARP targeted therapy in HR proficient ovarian cancer.
Morpho-physiological responses of peppermint (Mentha x piperita L.) by seaweed floair under salinity stress
Authors: Hakimzadeh Mohammad Ali , koshkenow hamideh jafarzade , sodaeizadeh hamid , Esfandiari Motahareh
Published: November 2022

seaweed has developed as a cure with the capability to spare the biological system, because of its eco-friendliness, reasonableness, accessibility, and active ion expulsion rate. This work summarizes the result of saltiness on the organ of plants, and this biomass is revered because the driving redress material among the accessible materials too grandstand the bio activity part of seaweed extricate disengage and its adequacy as a valuable, on morphological and physiological characteristics of peppermint underneath completely different irrigation water salinity was conducted a factorial experiment supported a totally irregular style with four replications within the Yazd University greenhouse in 2020. Experimental factors included salinity stress at four levels of (0, 2, 4 and 8 dS/m) and, seaweed powder application at four levels of (0, 1, 2 and 4 ppt ). Morphological traits or growth parameters and physiological characteristics (relative water content, photosynthetic pigments, total soluble carbohydrate, proline amino acid) assessed. our results demonstrated that seaweed led to changes in peppermint growth and physiology which improved the plant salt stress response. Examination of interaction effects showed was a significant effect on total chlorophyll, chlorophyll a, chlorophyll b, carotenoids (Photosynthetic pigment) and, total soluble carbohydrate at the level of 1% (p≤0.01), and in examining morphological traits results demonstrated that fresh and dry weight of leaves, aerial components, total fresh and dry biomass and harvest index were significant at the level of 1% (p≤0.01). The use of seaweed at 4 ppt under stress-free conditions resulted in the highest weight of leaves, aerial, and total biomass. The highest relative water content was related to the without salinity stress (65.8%). The highest proline content was obtained at 4 and 8 dS/m salinity levels, which showed a rise of 37.5% compared to the management treatment. In general, the results showed that the employment of 2 and 4 ppt seaweed at high levels of salinity (4 and 8 dS/m) reduced the adverse effects of salinity stress by improved physiological traits, together with chemical change pigments and amino acid content. This analysis grandstands the bio activity part of seaweed growth biomass and its adequacy as a helpful, cheap, and reasonable.
Historical and Futuristic Perspectives on Seismic Site Effects in Turkiye-Izmir-Bayrakli Basin
Authors: Cetin Kemal Onder , Cakir Elife , Zarzour Moutassem
Published: November 2022

Due to the unique soil, morphological and subsurface topographical conditions, site effect-induced amplified and prolonged seismic demand traces were observed in historical strong ground motion records from Bayrakli-Izmir-Turkiye. A vivid example of these was documented after the recent October 30, 2020 normal event with Mw 7.0, which took place offshore of Samos Island and Seferihisar. During the event, structural damage and life losses were unexpectedly concentrated in Bayrakli-Izmir, even though the fault rupture was located 70 km away. The presence of strong ground motion stations located on rock and soil sites in Bayrakli enables quantitative assessment of this rather unique response. For this purpose, earthquake records starting from year 2010 till present were compiled and studied to assess intensity- or better to refer as strain- dependent Bayrakli basin-specific, nonlinear amplification factors. 1-D total stress-based equivalent linear site response assessments were performed to better understand and model these effects. Additionally, amplification factors were probabilistically estimated by following the modified analytical procedures. After having calibrated and validated the idealized 1-D models, they were used to predict the responses of the site during future, deterministic, more of design basis like scenario events. The results revealed that the 2475- year design basis spectral amplitudes for a ZE type site could be exceeded in Bayrakli by as much as 20 to 100% in the period range 1.5 to 3.5 seconds. Similarly, the amplification factors by Turkish earthquake code (TEC 2018) are expected to be exceeded under deterministic seismic scenarios on Izmir, Karaburun and Seferihisar faults, with Eurocode (2004) and NEHRP (2020) recommendations to be no exceptions. These clearly address the need to develop Bayrakli-specific seismic zonation and design practices due to its rather unique site effect-governed seismic response.
A bacterial formula with native strains as alternative to chemical fertiliser for tomato crop
Authors: Paganin Patrizia , Isca Clelia , Tasso Flavia , Calandrelli Tommaso , Migliore Giada , Medas Daniela , Dore Elisabetta , Marras Pier Andrea , De Giudici Giovanni , Sprocati Anna Rosa , Alisi Chiara
Published: November 2022

Worldwide productivity of tomato is threatened by biotic and abiotic stress factors. To sustain and guarantee an adequate yield of tomato crops, agricultural practices have been based on the intensive use of fertilisers with negative impacts on the environment. An eco-friendly and sustainable alternative to the traditional cultivation methods is the bioaugmentation approach, using tailor-made microbial consortia. Eight indigenous strains, isolated from the soil of “Terra-Sole” farm in the coastal plain of Pula (Sardinia - Italy), were selected in the laboratory for their plant growth promoting (PGP) functions. The beneficial effects of the bacterial formula, including genera Delftia, Pseudomonas, Paenarthrobacter, Phyllobacterium, Bacillus, and Acinetobacter, were tested in three subsequent field trials carried out at the company greenhouse, with different tomato varieties (Camone, Oblungo, Cherry). The results indicate that the inoculation of the indigenous bacterial formula repeated at the different stages of plant growth, regardless of the tomato variety, represents an effective strategy to obtain a fruit yield comparable to that obtained with chemical fertilisers. The application of proper biofertilisation could thus substitute the use of expensive and polluting chemicals without compromising the tomato yield.
A robust voice activity detection based on single frequency filtering approach and the fractal dimension
Authors: Abajaddi Nesrine , Elfahm Youssef , Zulfiqar Ali , Mounir Badia , Farchi Abdelmajid
Published: November 2022

The authors have requested that this preprint be removed from Research Square.
Diagenetic Systems of Cambrian DEPS in Eastern Sichuan Basin and Its Geological Significance
Authors: Wang Jixuan , Hu Zhonggui , Li Shilin , Zhang Na , Wang Wenjing
Published: November 2022

To determine the diagenesis and evolution of the Cambrian DEPS (dolomite-evaporite paragenesis system) in the eastern Sichuan basin, the isotopic geochemistry characteristics of C, O, and fluid inclusions were studied. Four diagenetic systems were determined in the Cambrian DEPS based upon the hydrological system. These include the pore brine during the penecontemporaneous stage, sealed brine during the early diagenetic stage, compaction hot brine during the middle and late diagenetic stage, and mixed hydrothermal fluids involving deep thermal water during the later tectonic uplift stage. The character and source of fluids of various diagenetic stages and systems have a certain familiarity and inheritance features of development and evolution. However, fluids of various diagenetic stages and systems have different effects on the reservoirs. The diagenetic systems and manner of diagenesis are related to reservoir development closely. These include burial dolomitization and dissolution of sealed brine of the early diagenetic stage, and TSR (thermochemical sulfate reduction) and recrystallization of the mixed hydrothermal fluids involving deep thermal water during the tectonic uplift stage. Analyzing the basin structure indicates that a series of faults caused by the Cambrian detachment layer in the Eastern Sichuan Basin are the dominant factor controlling the spatiotemporal coupling relationship between the diagenetic systems and the reservoir in DEPS. The grain shoal subfacies control the regional distribution of the reservoir. During the early diagenetic stage, buried dolomitization helped with continued reservoir development, while TSR and recrystallization in the tectonic diagenetic stage improved reservoir quality by enhancing porosity and permeability. The Cambrian DEPS strata and the underlying Qiongzhusi Formation mud shale form a high-quality source-reservoir-caprock assemblage in the eastern Sichuan Basin.
The Communal Pathogenesis, Autophagy Mechanism and Potential Therapeutic Targets in Dilated Cardiomyopathy and Viral Myocarditis
Authors: Wu Jiahe , Zhu Haoyan , Cao Jianlei , Cai Huanhuan , Wang Qiongxin , Lei Zhe , Lu Yi , Lu Zhubing , Hu Xiaorong
Published: November 2022

Background: Viral myocarditis (VMC) is an important factor leading to dilated cardiomyopathy (DCM), yet the molecular mechanism is far from elucidated. Autophagy has been proven to be associated with cardiomyopathies, but the role of autophagy in the progression from VMC to DCM is unclear and requires further study.
Methods: Common differentially expressed genes (CoDEGs) in DCM and VMC were screened from the related microarray datasets. Enrichment analysis and protein-protein interaction analysis were performed to identify key pathways and Hub Genes. The differentially expressed ARGs were used for receiver operating characteristic analysis to identify potential biomarkers. The expression of these identified genes was further verified in external datasets.
Results: A total of 134 CoDEGs were identified and these genes were mainly enriched in the pathways of “inflammatory response”, “response to virus”, “JAK-STAT signaling pathway”, and “PI3K-Akt signaling pathway”. The top 6 hub genes CCND1, STAT3, THBS1, CCL2, POSTN, IFIT2 and 11 Common differentially expressed ARGs BCL2L1, CCL2, CCND1, NAMPT, NRG1, S100A8, S100A9, SESN3, SNCA, STAT3, TUBA1C were identified. These genes had a similar expression pattern in DCM and VMC. Finally, in the external validation dataset, mice showed an enhanced inflammatory response and apoptotic response at the initial stage of coxsackievirus B3 infection and indicated DCM phenotype in the chronic stage of infection.
Conclusions: Inflammatory response and autophagy may be the vital biological pathways in the progression from VMC to DCM, and appropriate intervention of these processes may be a novel and potential therapeutic strategy.
Linked Distinct Multi-modular Brain Connectivity Patterns with Retina Microvascular and Structural Alterations, and Their Correlations with Visual Performance in Thalamic Stroke
Authors: Ye Chen , Kwapong William Robert , Tang Biqiu , Liu Junfeng , Tao Wendan , Lu Kun , Pan Ruosu , Wang Anmo , Liao Lanhua , Yang Tang , Cao Le , Wang Youjie , Jiang Shuai , Zhang Xuening , Liu Ming , Wu Bo
Published: November 2022

The neuro-ophthalmologic symptoms and retinal changes have been increasingly noticed after thalamic stroke and increasing evidence showing distinct alterations occurred in the vision-related functional network, while their intrinsic correlations are not completely understood. We aimed to explore the altered of functional network linking patterns and retina parameters, and their correlations with visual performance in thalamic stroke patients. Multi-modular functional connectivity (FC) was obtained with resting-state functional MRI. Optical coherence tomography-angiography was used to obtain retina parameters (retinal nerve fiber layer, RNFL; ganglion cell-inner plexiform layer, GCIP; superficial vascular complex, SVC; and deep vascular complex, DVC). Visual performance was measured through visual acuity (VA). Forty-six patients with first-ever unilateral thalamic stroke (mean age 59.74 ± 10.02 years, 33 males) were included. Significant associations were found in FC of Attention-to-Default Mode with SVC, RNFL, and GCIPL, and in FC of Attention-to-Visual with RNFL (p < 0.05). Both RNFL and GCIPL were significantly associated with the FC of Visual-to-Visual (p < 0.05). Only GCIPL was associated with VA (p = 0.038). In stratified analysis based on the disease duration of 6-month, distinct and significant linking patterns were displayed in muti-modular FC and various certain retina parameters; and their correlations with VA varied in each subgroup, respectively. These findings provide new insight into the understanding of the neural basis of the associations between brain network dysfunction and impaired visual performance in patients with thalamic stroke. Our findings are novel and might benefit targeted and individualized therapies in the future. Further in-depth studies are needed to verify our results.
On the regularity of generalized random spectral measures and their applications
Authors: Nguyen Thinh , Hung Thang Dang , Cong Son Ta
Published: November 2022

This paper is devoted to the regularity of generalized random spectral measures. First, we prove that every generalized random spectral measure defined on a locally compact metric space with values in a separable Hilbert space is regular. A solution of the Schrödinger-type random equation is obtained as an application. In the second part of this paper, we show that every finitely additive generalized random spectral measure defined on an arbitrary measurable space with values in a finite-dimensional Hilbert space is also regular. In addition, an random version of Jordan’s classical decomposition theorem for a matrix is provided.
Subject Classification. Primary 60H25; Secondary 46G10, 60B11, 45R05.
Comparison of genetic variations between high- and low-risk Listeria monocytogenes isolates using whole-genome de novo sequencing
Authors: Ryu Jihye , Choi Yukyung , Yoon Yohan
Published: November 2022

In this study, genetic variations and characteristics of Listeria monocytogenes isolates from enoki mushrooms (23), smoked ducks (7), and processed ground meat products (30) were examined with respect to hemolysis, virulence genes, growth patterns, and heat resistance. The isolates that showed the highest pathogenicity were analyzed to obtain the whole-genome sequence, and the sequences were further analyzed to identify genetic variations in virulence, low-temperature growth-related, and heat resistance-related factors. All isolates had β-hemolysis and virulence genes (actA, hlyA, inlA, inlB, and plcB). At low temperatures, isolates with high growth (L. monocytogenes strains SMFM 201803 SD 1-1, SMFM 201803 SD 4-2, and SMFM 201804 SD 5-3) and low growth (L. monocytogenes strains SMFM 2019-FV43, SMFM 2019-FV42, and SMFM 2020-BT30) were selected. Among them, L. monocytogenes SMFM 201804 SD 5-3 showed the highest resistance at 60°C and 70°C. The strains SMFM 201804 SD 5-3 (high-risk) and SMFM 2019-FV43 (low-risk) harbored 45 virulence genes; 37 single nucleotide variants (SNVs) and 4 single nucleotide polymorphisms (SNPs; lntA, inlK, actA, and plcB) were identified between these two isolates. A comparison of 27 genes related to low-temperature growth revealed 14 SNVs and 4 SNPs (motA, ltrC, betL, and gbuB) between these two isolates; a comparison of the 21 genes related to heat resistance revealed 16 SNVs. These results indicate that the differences in the pathogenicity of L. monocytogenesSMFM 201804 SD 5-3 and L. monocytogenesSMFM 2019-FV43 are associated with the SNPs identified in virulence (lntA, inlK, actA, and plcB) and low-temperature growth-related (gbuB, betL, motA, and ltrC) genes.
Chronos-V: A Many-Core High-level Model with Support for Management Techniques
Authors: Weber Iaçanã , Zotto Angelo Elias Dal , Moraees Fernando Gehm
Published: November 2022

This work presents Chronos-V, a Many-Core System-on-Chip (MCSoC) that adopts abstract hardware modeling, executing the FreeRTOS Operating System (OS) at each processing element (PE). Chronos-V is a heterogeneous architecture with two regions: (i) General Purpose Processing Elements (GPPE), responsible for executing user applications; (ii) peripherals that provide IO capabilities or hardware acceleration to the system. Besides the standard goal of high-level models, design space exploration at early design stages with reduced simulation time, our goal is to advance the state-of-the-art in the MCSoC research field by proposing an architecture with hardware and software support for management techniques. As a case study, we present an ODA (Observe-Decide-Actuate) loop for thermal management, comparing it to a dark silicon patterning mapping in a platform with 196 PEs. Thermal maps show the benefits of using dynamic thermal management in terms of hotspot avoidance and temperature reduction.
Mineralogy, geochemistry and depositional environment of phosphates in the Pabdeh Formation, Khormuj anticline, SW of Iran
Authors: Haddad Fatemeh , Yazdi Mohammad , Behzadi Mehrdad , Yakymchuk Chris , Khoshnoodi Khalegh
Published: November 2022

Phosphate deposits are found in the Khormuj anticline at the end of the Folded Zagros Zone of Iran and are enriched in REE and trace metals. Field survey, petrography, X-ray diffraction and whole-rock geochemistry were used to determine the petrogenesis of these phosphate deposits and evaluate the mechanisms of trace metal enrichment. Khormuj anticline phosphate layers are hosted by carbonate rocks of the Pabdeh Formation (Lower Paleocene-Oligocene). The phosphatic layers are composed of phosphorus grainstone–packstone with microfossils and contains green glauconite. Whole-rock compositions of phosphates indicate a minimal detrital component and enrichment in U and HREE. These elements are not enriched in the limestone units that overlie and underlie the phosphate layers. Overall, the textures and trace element compositions of phosphate layers are interpreted to represent accumulation on a basin margin carbonate ramp, in the reduced and suboxic-to-anoxic zone, with low detrital input but occasional high-energy erosional events. Upwelling process played a fundamental role in the deposition of the sandy glauconite-bearing phosphate layers. Phosphate mineralization has syngenetic, diagenetic, and epigenetic components. Positive correlations between P2O5 and REE, U and other trace elements suggest that cation substitution into carbonate fluorapatite and not ion adsorption is the dominant mechanism for metal enrichment in these phosphates. REE patterns in these phosphate layers show strong negative Ce anomalies, positive Eu and Y anomalies and high La/Yb ratios (> 10). Yttrium versus (La/Nd)N ratios are in the seawater range and have been affected by diagenesis process. These elevated ratios suggest that the phosphates are relatively enriched in both the LREE and HREE. This enrichment is related to their marine origin, and weathering had no effect on the phosphate horizons. This research show that marine phosphates have high potential to preferentially fractionate the HREE and U and could represent a future source of these metals.
Factors Influencing Willingness-to-repurchase Airline Services in Nigeria
Authors: Adeniran Adetayo Olaniyi , Njoku Ikpechukwu , Stephens Mobolaji S.
Published: November 2022

Background: This study examined the factors influencing willingness-to-repurchase for each class of airline service, and integrate the constructs of service quality, satisfaction, and willingness-to-repurchase which were rooted on Engel-Kollat-Blackwell (EKB) model. The study focuses on the domestic and international arrival of passengers at Murtala Muhammed International Airport in Lagos and Nnamdi Azikwe International Airport in Abuja. Information was gathered from domestic and foreign passengers who had post-purchase experience and had used the airline's services more than once. The survey data were obtained concurrently from arrival passengers at two major international airports in Lagos and Abuja using an electronic questionnaire. The e-questionnaire targeted 606 respondents using purposive sampling and snowball sampling techniques. The data was analysed using the ordinal logit model and structural equatin model.
Results: From the 606 respondents, 524 responses were received but 489 responses were valid for data analysis and reporting and were obtained mostly from economy and business class passengers. The study found that the quality of 30-32 inches seat pitch; accessibility to digital TV during flight; allowance of 30kg luggage permission; and availability of online check-in 24 hours before the departing flight are the major service factors influencing willingness-to-repurchase for an economy ticket. Also, the quality of space for legroom between seats is wide (79 to 87 inches seat pitch) and the quality of seats can be converted into a fully flat bed; are the major service factor influencing willingness-to-repurchase economy tickets. Also, it was found that passengers' willingness to repurchase is influenced majorly by service quality, but not necessarily influenced by satisfaction.
Conclusions: The study identified the factors influencing willingness-to-repurchase for economy and business class tickets. It was concluded that seat comfort and baggage handling are most crucial in bth economy and business class tickets. From these findings, it was revealed that airlines will be able to have a better understanding of passengers’ willingness-to-repurchase airline services, especially for the economy and business fares concerning satisfaction perspectives, and can also be employed to improve business profitability and airline marketing capabilities.Recommendations were suggested for airline management based on each class.
SDAM: Semantic Annotation Model for Multi-modal Short Videos Based on Deep Neural Network
Authors: Behera Mohana , Kumar Lakshimi , Mishra Lopez , Park Patrick
Published: November 2022

Video content analysis has a variety of application scenarios, including automatic content-based indexing and retrieval, video surveillance content description, automatic addition of dialogue subtitles for video, etc., which are urgently needed by enterprises and governments. These application scenarios currently require a large amount of manpower to label the specific content of the video, training the relevant personnel will cost a lot of resources, and the efficiency of manual labeling is low, if we can use computers to automatically analyze the video content will save a lot of costs for the relevant industries and bring revolutionary development. Traditional video analysis methods mainly rely on manually constructed features for matching to achieve the coarse classification of video, often dividing the video into a few categories or a dozen categories simply, which cannot be in line with the era of big data. Therefore, how to use the existing data resources and technical means to complete the content analysis of videos gradually becomes the focus of research. For the characteristics of large data volume and real-time of short videos, fast extraction of key frames containing the main information is the direction to focus on.
In this paper, we will consider the characteristics of short video multi-modality and fully exploit the information of each modality of short video. We focus on the semantic annotation methods for short videos. To address the problem that traditional video analysis methods cannot obtain high-value semantic information within the video, this paper first obtains key frames from the video that represent the main information of the video by key frame extraction technique. Based on migration learning, we use pre-trained models to improve the target detection and image description algorithms, extract the high-value regions in key frames, and perform semantic description. The research can better address the needs of short video content analysis and provide data basis for subsequent deep application scenarios.
Larviciding intervention targeting malaria vectors also affects Culex mosquito distribution in the city of Yaoundé, Cameroon.
Authors: Talipouo Abdou , Doumbe-Belisse Patricia , Ngadjeu Carmène S. , Djamouko-Djonkam Landre , Nchoutpouen Elysée , Bamou Roland , Sonhafouo-Chiana Nadège , Mayi Audrey Paul Marie , Foko Gisèle Aurélie Dadji , Awono-Ambene Parfait , Kekeunou Sévilor , Wondji Charles S. , Antonio-Nkondjio Christophe
Published: November 2022

Although Culex species are considered to be equally affected by control measures targeting malaria vectors, there are still not enough evidences of the impact of interventions such as larviciding on these mosquito species distribution. The present study assessed the impact of a larviciding trial targeting malaria vectors on Culex mosquito species in the city of Yaoundé. A cluster randomized trial comparing thirteen treated clusters and thirteen untreated clusters was implemented. Data were collected at baseline and during larviciding intervention, from March 2017 to November 2020. The microbial larvicide VectoMax G was applied once every 2 weeks in intervention areas. Adult mosquitoes were collected using CDC light traps in both intervention and non-intervention areas and compared between arms. Globally, larviciding intervention was associated with 69% reduction in aquatic habitats with Culex larvae and 36.65% reduction of adult Culex densities in houses. Adult Culex densities were reduced both indoor (35.26%) and outdoor (42,37%). No change in the composition of Culex species was recorded. The study suggested a high impact of larviciding on Culex mosquito species distribution. The impact of the intervention could be improved if typical Culex breeding habitats including pit latrines were targeted.
Intersubband Transitions in Nonpolar ZnO/BeMgZnO Quantum Wells: Effects of Physical Dimension, Concentration and Donor Level
Authors: YILDIRIM Hasan , ÇAKIR Raşit
Published: November 2022

Polarizaton properties of ZnO well layers on BeMgZnO barrier layers grown in polar and semipolar orientations have been investigated. Cases of relaxed and strained barrier layers are considered. It is found that the polarizaton difference at the interfaces leads to a built-in electric field inside the well layer as much as 8 MV cm^(-1) in magnitude. Nonpolar ZnO/BeMgZnO quantum wells have been studied in terms of intersubband transitions. The calculations have covered Be and Mg concentrations up 0.18 and 0.5, respectively. It has been found that intersubband transition (ISBT) energies ranging from 50 to 700 meV are possible. The effect of barrier thickness on the ISBT energies has been studied. The results indicate insignificant changes in ISBT energies compared to the energies.
Synthesis of Novel 3-Oxobutanohydrazide Derivatives in the Presence of Cerium Ammonium Nitrate
Authors: ASLANOĞLU Furgan
Published: November 2022

In this study, a new synthetic method was developed for new 3-oxobutanohydrazide derivatives. This synthetic method consists of two steps. In the first step, aldehyde phenyl hydrazone derivatives were synthesized. Then, these compounds were reacted with 2,2,6-trimethyl-4H-1,3-dioxin-4-one (TMD) compound in the presence of the catalytic amount of cerium ammonium nitrate and 3-oxobutanohydrazide derivatives, which are new target molecules, were synthesized. The structures of the synthesized 3-oxobutanohyidrazide derivatives were characterized by 1H-NMR and 13C-NMR.
High-efficiency sediment-transport requirements for operation of the Xiaolangdi Reservoir in the Lower Yellow River
Authors: Chen Cuixia , Fu Jian , Wu Moxi , Gao Xing , Ma Liming
Published: November 2022

Sediment accumulation is severe in the Lower Yellow River. Improving sediment-transport efficiency is an important way to save water resources. In this study, we analyzed the sediment-transport efficiency at different sediment concentrations and discharge levels using data from 306 non-overbank floods in the lower reaches of the Yellow River from 1960 to 2016. When the sediment concentrations were below 20 kg/m3, 60 kg/m3, and greater than 100 kg/m3, the clear water volumes for transporting sediment were above 50 m3/t, approximately 16 m3/t, and less than 10 m3/t, respectively. Given current scheduling, the Xiaolangdi Reservoir can lower its water level and increase non-overbank large water flows with an outflow discharge of >3,000 m3/s when the incoming water flow has a sediment concentration of >60 kg/m3. Mathematical modeling indicates that, for an incoming sediment load of 600 million tons in the Middle Yellow River, the average sediment-transport water volume at the downstream Huayuankou Station decreased by 27%, Optimized scheduling at the Xiaolangdi Reservoir could reduce the sedimentation in the downstream channel by 1.1 billion tons more than current scheduling, and extend the reservoir's sediment-trapping period by ten years. These findings can be applied widely in sandy rivers.
Dual-energy CT Virtual Non-Calcium Image is Beneficial for the Detection
of Non-displaced Knee Fractures
Authors: Fang Yijie , Liu Chaoran , Yu Wen , Zhan Yingying , Li Wenjuan , Liang Jianchao , Hong Guobin
Published: November 2022

Background:

Early and accurate diagnosis is vital for avoiding the development of nondisplaced
fractures to displaced fractures. Dual-energy CT (Computed Tomography) can detect bone
marrow edema (BME), which may help to detect non-displaced fractures.

Aim:

To evaluate the value of DECT (Dual-Energy Computed Tomography) VNCa (Virtual noncalcium)
images for improving diagnostic performance and confidence in acute non-displaced knee
fractures.

Methods:

125 patients with clinical suspicion of knee fractures underwent both DECT and MR. Conventional
linear-blended CT and VNCa images were obtained from DECT. First, five readers with
varying levels of experience evaluated the presence of fractures on conventional linear-blended CT
and graded their diagnostic confidence on a scale of 1 to 10. Then BME with VNCa images was evaluated
and compared with MR. Finally, the VNCa images combined with conventional linear-blended
CT images were used to reassess the presence of fractures and diagnostic confidence. Diagnostic performance
and matched pair analyses were performed.

Results:

20 non-displaced knee fractures were detected. The consistency test of VNCa images and MR
by five radiologists showed Kappa values are 0.76, 0.79, 0.81,0.85,and 0.90,respectively. The diagnostic
performance of all readers was improved when using VNCa images combined with conventional
linear-blended CT compared with that with conventional linear-blended CT alone. Diagnostic confidence
was improved with combined conventional linear-blended CT and VNCa images (median
score:8,8,9,9, and 10, respectively) compared with conventional linear-blended CT alone (median
score:7,7,8,9, and 9).

Conclusion:

DECT VNCa images could improve the radiologists' diagnostic performance and confidence
with varying levels of experience in the detection of non-displaced knee fractures.
An Update on Recently Developed Analytical and Bio-analytical Methods for Some Anticancer Drugs
Authors: Kumar Bhupinder , Akhtar Md Jawaid , Paul Joyson , Singh Karanvir , Pannu Sumit , Pal Rohit , Khan Shah Alam
Published: November 2022

Abstracts:

According to the WHO’s data for 2018, the global cancer burden was estimated to have risen to 18.1 million new cases and which alone accounted for 9.6 million deaths. Cancer is a group of diseases known as tumors that often spreads throughout the body, and may cause harm to multiple organs in the body. The global pharmaceutical spending is around 19% of the R&D cost annually to discover new and potent therapeutic agents. The major problems associated with currently available anticancer drugs are drug resistance and their side effects. They are the most widely explored groups of drugs either using instrumental or bioanalytical methods. In this review, we have compiled and reviewed the analytical and bio-analytical methods of some anticancer drugs developed by different authors. The review also briefly discusses the broad categories of cytotoxic drugs and targeted-based anticancer drugs. The analytical and bioanalytical methods of cytotoxic drugs such as alkylating agents, antimetabolites, hormones, and targetedbased drugs reported earlier and in recent research, articles are discussed in detail. These analytical methods are prerequisites for both the pharmaceutical industry and academics for their impurities profiling and qualitative as well as quantitative estimation. The accuracy, precision, LOD, and LOQ studies by UV-HPLC, LC-MS, and fluorometry HPLC are discussed. Some of the advanced methods developed, in the case of ifosfamide using Au/Pd@rGO@p(L-Cys) and the production of vincristine by endophytic fungi, are also included. This will further embolden the efforts of different researchers working in this field and ease the challenges they face through the analytical development of these drugs.
Evaluation of Water Sorption and Solubility of Nano Titania Enriched Glass Ionomer Cement Considering the Storage Solution and Time
Authors: Hussein Fatma
Published: November 2022

Background:

A biocompatible additive to glass ionomer cement types without affecting their stability in moisture and dry conditions in demand.TiO2NPs are stable and bioactive nanoparticles that improved the mechanical properties of GICs, but their impact on water sorption and solubility remains undetermined.

Purpose:

This study aimed to evaluate the water sorption/solubility of glass ionomer cement incorporating titanium dioxide nanoparticles (TiO2NPs) in different storage solutions over time.

Methods:

A total of 60 glass ionomer discs were fabricated, and they were divided into two groups (n=30); conventional glass ionomer (control), TiO2 NPs modified glass ionomer. Each group was subdivided into three subgroups according to the type of storage solution used (n=10); artificial saliva, mouthwash with alcohol, and mouthwash without alcohol. Water sorption% and solubility% were recorded after immersion of specimens in the storage solutions according to the subdivided groups; at 24hrs, 1 week, and 1 month.

Results:

TiO2NPs were associated with a significant decrease in sorption% in artificial saliva at 1 week, alcohol at 24hrs, and a significant decrease in solubility% in all storage solutions at 24hrs and artificial saliva at 1 week. There was a significant decrease in water uptake associated with both materials in artificial saliva, also with TiO2NPs modified type in alcohol-free mouth washes. There was a gradual significant increase in solubility% for conventional GIC in artificial saliva and TiO2NPs modified type in alcohol (p≤0.05).

Conclusion:

TiO2NPs may play a promising role in improving water sorption and solubility of conventional GIC, considering the type of storage solution and time.
Patterns in the Use of Heart Failure Telemonitoring: Post Hoc Analysis of the e-Vita Heart Failure Trial
Authors: Brons Maaike , ten Klooster Iris , van Gemert-Pijnen Lisette , Jaarsma Tiny , Asselbergs Folkert W , Oerlemans Marish I F J , Koudstaal Stefan , Rutten Frans H
Published: November 2022

Background

Research on the use of home telemonitoring data and adherence to it can provide new insights into telemonitoring for the daily management of patients with heart failure (HF).

Objective

We described the use of a telemonitoring platform—including remote patient monitoring of blood pressure, pulse, and weight—and the use of the electronic personal health record. Patient characteristics were assessed in both adherent and nonadherent patients to weight transmissions.

Methods

We used the data of the e-Vita HF study, a 3-arm parallel randomized trial performed in stable patients with HF managed in outpatient clinics in the Netherlands. In this study, data were analyzed from the participants in the intervention arm (ie, e-Vita HF platform). Adherence to weight transmissions was defined as transmitting weight ≥3 times per week for at least 42 weeks during a year.

Results

Data from 150 patients (mean age 67, SD 11 years; n=37, 25% female; n=123, 82% self-assessed New York Heart Association class I-II) were analyzed. One-year adherence to weight transmissions was 74% (n=111). Patients adherent to weight transmissions were less often hospitalized for HF in the 6 months before enrollment in the study compared to those who were nonadherent (n=9, 8% vs n=9, 23%; P=.02). The percentage of patients visiting the personal health record dropped steadily over time (n=140, 93% vs n=59, 39% at one year). With univariable analyses, there was no significant correlation between patient characteristics and adherence to weight transmissions.

Conclusions

Adherence to remote patient monitoring was high among stable patients with HF and best for weighing; however, adherence decreased over time. Clinical and demographic variables seem not related to adherence to transmitting weight.

Trial Registration

ClinicalTrials.gov NCT01755988; https://clinicaltrials.gov/ct2/show/NCT01755988