bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypertuning-Based Ensemble Machine Learning Approach for Real-Time Water Quality Monitoring and Prediction
Authors: Shahid Md. Shamim Bin , Rifat Habibur Rahman , Uddin Md Ashraf , Islam Md Manowarul , Mahmud Md. Zulfiker , Sakib Md Kowsar Hossain , Roy Arun
Published: September 2024

In the present day, the health of the populace is significantly jeopardized by the presence of contaminated water, and the majority of the population is unaware of the distinction between safe and unsafe water consumption. Agricultural, industrial, and other human-induced activities are causing a significant decline in the availability of drinking water. Consequently, the issue of ensuring the safety of ingesting water is becoming increasingly prevalent. People should be aware of the purity of the water and the locations where it can be used in order to resolve this situation. There are numerous IoT-based system architectures that are capable of monitoring water parameters; however, the majority of these architectures do not allow for real-time water quality prediction or visualization. In order to achieve this, we suggest a wireless framework that is based on the Internet of Things (IoT). The sensors are able to capture water parameters and transmit the data to the cloud, where a machine learning (ML) model operates to classify the water quality. After that, Grafana enables us to effortlessly visualize the real-time data and predictions from any location. We employed a multi-class dataset from China for the model’s construction. GridSearchCV was implemented to identify the optimal parameters for model optimization. The proposed model is a combination of the Random Forest (RF), Extreme Gradient Boosting (XGB), and Histogram Gradient Boosting (HGB) models. The accuracy of the model for the China dataset was 99.80%. To assess the robustness of the proposed model, we acquired a new dataset from the Bangladesh Water Development Board (BWDB) and used it to test the proposed model. The model’s accuracy for this dataset was 99.72%. In summary, the proposed wireless IoT framework enables individuals to effortlessly monitor the purity of water and view its parameters from any location.
Characteristics and Source Identification for PM2.5 Using PMF Model: Comparison of Seoul Metropolitan Area with Baengnyeong Island
Authors: Kim Kyoung-Chan , Song Hui-Jun , Lee Chun-Sang , Lim Yong-Jae , Ahn Joon-Young , Seo Seok-Jun , Han Jin-Seok
Published: September 2024

To establish and implement effective policies for controlling fine particle matters (PM2.5), which is associated with high-risk diseases, continuous research on identifying PM2.5 sources was conducted. This study utilized the positive matrix factorization (PMF) receptor model to estimate the sources and characteristics of PM2.5 between Baengnyeong Island (BNI) and the Seoul Metropolitan Area (SMA). We conducted PMF modeling and backward trajectory analysis using the data on PM2.5 and its components collected from 2020 to 2021 at the Air quality Research Centers (ARC). The PMF modeling identified nine pollution sources in both BNI and the SMA, including secondary sulfate, secondary nitrate, vehicles, biomass burning, dust, industry, sea salt particles, coal combustion, and oil combustion. Secondary particulate matter, vehicles, and biomass burning were found to be major contributors to PM2.5 concentrations in both regions. A backward trajectory analysis indicated that air masses, passing through BNI to the SMA, showed higher concentrations and contributions of ammonium nitrate, vehicles, and biomass burning in the SMA site compared to BNI site. These findings suggest that controlling nitrogen oxides (NOx) and ammonia emissions in the SMA, as well as monitoring the intermediate products that form aerosols, such as HNO3, are needed.
Characterization and Expression Analysis of the C-Type Lectin Ladderlectin in Litopenaeus vannamei Post-WSSV Infection
Authors: Xue Qian , Yang Bingbing , Luo Kun , Luan Sheng , Kong Jie , Fu Qiang , Cao Jiawang , Chen Baolong , Dai Ping , Xing Qun , Li Xupeng , Meng Xianhong
Published: September 2024

C-type lectins are known for agglutination activity and play crucial roles in regulating the prophenoloxidase (proPO) activation system, enhancing phagocytosis and encapsulation, synthesizing antimicrobial peptides, and mediating antiviral immune responses. This work cloned a C-type lectin, ladderlectin (LvLL), from Litopenaeus vannamei. LvLL comprised a 531 bp open reading frame (ORF) that encoded 176 amino acids. The predicted LvLL protein included a signal peptide and a CLECT domain. LvLL was predicted to feature a transmembrane region, suggesting it may be a transmembrane protein. LvLL was predominantly expressed in the shrimp’s hepatopancreas. After WSSV infection, LvLL expression in the hepatopancreas increased significantly by 11.35-fold after 228 h, indicating a general upregulation. Knockdown of LvLL resulted in a significant decrease in WSSV viral load and a notable increase in shrimp survival rates. Additionally, knockdown of LvLL led to a significant downregulation of apoptosis-related genes Bcl-2 and caspase 8 and a significant upregulation of p53 and proPO in WSSV-infected shrimp. This study showed that LvLL played a vital role in the interaction between L. vannamei and WSSV.
Linking Sleep Disorders to Atrial Fibrillation: Pathways, Risks, and Treatment Implications
Authors: Ferreira Monica , Oliveira Mario , Laranjo Sergio , Rocha Isabel
Published: September 2024

Sleep is a complex biobehavioural process essential for overall health, with various dimensions including duration, continuity, timing, and satisfaction. This study investigated the intricate relationships between common sleep disorders such as insomnia and obstructive sleep apnoea (OSA) and their impact on atrial fibrillation (AF), a prevalent arrhythmia with significant health implications. Using a comprehensive review of the current literature, this study examined the pathophysiological mechanisms linking sleep disorders to cardiovascular risks, focusing on autonomic nervous system disturbances, inflammation, and oxidative stress associated with OSA. These findings indicate that sleep disorders significantly elevate the risk of AF through mechanisms such as increased sympathetic activity and structural cardiac remodelling. Additionally, this study highlights the potential benefits of treating sleep disorders, particularly with continuous positive airway pressure (CPAP) therapy, in reducing AF recurrence and improving cardiovascular outcomes. This conclusion emphasises the importance of integrated therapeutic approaches that address both sleep disorders and AF to enhance patient outcomes and quality of life. Future research should explore these connections to develop more effective and holistic treatment strategies.
Searching for a Novel HLA-Cw6-Linked Cardiometabolic Endotype in Psoriatic Disease
Authors: Queiro Rubén , González del Pozo Pablo , Alvarez Paula , Calleja Norma , Braña Ignacio , Loredo Marta , Pardo Estefanía , Burger Stefanie , Alonso Sara , Alperi Mercedes
Published: September 2024

Background/Objectives: In recent years, a possible connection between HLA-Cw6 and a distinctive cardiometabolic (CM) profile in patients with psoriatic disease (PsD) has been proposed, although there is still little support for this. Our aim was to further investigate this possible association by studying a large population of PsD patients. Methods: For this study, three different cohorts of patients with PsD were analyzed: two with a majority of cutaneous psoriasis, pooled n: 600, and a third with only psoriatic arthritis—PsA—cases, n: 340. Potential relationships between HLA-Cw6 and the different CM risk factors (hypertension, diabetes, obesity, dyslipidemia) were analyzed using univariate and multivariate regression models, while the final net effect was assessed using fixed- or random-effects meta-analyses, as appropriate. Results: In the PsA cohort, no association was detected between HLA-Cw6 carriership and any of the CM comorbidity factors. In psoriasis cohorts, after correcting for age, sex, disease duration, and arthritis, HLA-Cw6 carriers had a reduced diabetes risk (OR 0.49, 95%CI: 0.26–0.91, p = 0.026). This latter effect was confirmed by a fixed-effects meta-analysis of the included cohorts (pooled OR: 0.50, 95%CI: 0.27–0.90). Conclusions: This work demonstrates a potential protective effect of the HLA-Cw6 allele on the risk of diabetes in PsD. Our findings together with those of others seem to confirm the existence of a novel HLA-Cw6-linked cardiometabolic endotype in this disease.
High Throughput Screening of Transcription Factor LysG for Constructing a Better Lysine Biosensor
Authors: Li Qinggang , Ren Haojie , Liao Zhenjiang , Xia Shuchang , Sun Xue
Published: September 2024

The biosensors based on transcription factors (TFs) are widely used in high throughput screening of metabolic overproducers. The unsatisfactory performances (narrow detection and dynamic ranges) of biosensors limit their practical application and need more improvement. In this study, using the TF LysG (sensing lysine) as an example, a biosensor optimization method was constructed by growth-coupled screening of TF random mutant libraries. The better the performance of the biosensor, the faster the strain grows under screening pressure. A LysGE15D, A54D, and I164V-based biosensors were obtained, which were about 2-fold of the control in the detection and dynamic ranges. A lysine high-producer was screened effectively using the optimized biosensor with the production at 1.51 ± 0.30 g/L in flasks (2.22-fold of the original strain). This study provided a promising strategy for optimizing TF-based biosensors and was of high potential to be applied in the lysine high-producers screening process.
Sustainability of Technical and Vocational Education and Training (TVET) along with Vocational Psychology
Authors: Ye Jian-Hong , He Zhen , Bai Bin , Wu Yu-Feng
Published: September 2024

Since the first Industrial Revolution in the 18th century, the gap for technical talent began to widen, and the concept of large-scale technical and vocational education and training (TVET) began to be advocated [...]
Multi-Criteria Decision-Making Framework (AHP-TOPSIS): Pavement Preventive Maintenance Case Study for Ordinary National Trunk Highways
Authors: Liu Yaohan , Yu Chun , Guo Feiyang , Zhao Xin , Shan Jinhuan , Lu Tong , Peng Hongxin , Yuan Dongdong
Published: September 2024

Pavement maintenance and rehabilitation decision-making needs to weigh multiple strategic goals to achieve sustainable development through the pavement maintenance management system. Making decisions regarding pavement preventive maintenance is both intricate and costly. This study introduces a multi-criteria decision-making framework aimed at enhancing the scientific basis of such decisions. The framework first establishes an evaluation system for preventive maintenance strategies by considering three primary evaluation criteria—service functionality, pavement performance, and economic benefits, and then identifies nine specific evaluation indicators to influence these criteria, with a comparison matrix constructed to determine the weight of each indicator in relation to the maintenance decision hierarchy. Following this, the technique for order preference by similarity to ideal solution (TOPSIS) is employed to prioritize four commonly utilized preventive maintenance strategies. The results reveal that pavement condition and maintenance costs are the most influential factors in determining the appropriate preventive maintenance strategies for national highways. The priority rankings for the four strategies—slurry seal, micro-surfacing, chip seal, and ultra-thin overlays—are found to be 56.12%, 63.86%, 12.12%, and 83.52%, respectively, with ultra-thin overlays identified as the optimal choice for second-class highways. The decision-making model utilized in this study enables a multi-dimensional analysis, reducing the subjectivity inherent in expert evaluations and facilitating the prompt identification of the most suitable maintenance strategy.
Deformation Characteristics and Influence Factors of Shear Force Lateral Stiffness Matching Index for Non-Rigid Plate Bent Frame Structures
Authors: Li Yulong , Zhao Pengfei , Xue Wen , Zhang Qiang , Ye Changjie , Ma Ming
Published: September 2024

The period ratio and the drift ratio are commonly used as plane regularity control indices for multi-story buildings. However, they fail to reasonably reflect the regularity of lateral force-resisting component configuration and deformation characteristics in non-rigid plate bent frame structures. This study focuses on the analysis of non-rigid single-span bent frames, examining the variation patterns of a suitable regularity index for non-rigid plate bent frame structures, referred to as the shear force lateral stiffness matching index, under various parameters. Additionally, it introduces indices to quantify the deformation response of non-rigid plate bent frame structures, providing a detailed analysis of the impact of factors such as eccentricity, torsional stiffness, and roof slab stiffness on the deformation characteristics of non-rigid plate bent frame structures and the shear force lateral stiffness matching index. The results show that the shear force lateral stiffness matching index can reflect the inconsistency in the horizontal displacement response of lateral force-resisting components caused by deformations in the roof slab. The proposed indices for torsional and bending deformations accurately quantify the roof slab’s deformation response, revealing the horizontal deformation characteristics of lateral force-resisting components in non-rigid frames. When eccentricity is present, the stiffness of the roof slab has a non-monotonic effect on the torsional component of the structural seismic response.
An Innovative Composite Wall Inner Tie System Applied to Reinforced Concrete Modular Integrated Construction
Authors: Zou Xiaokang , Huang Jiang , Lu Wenjie , Shi Jun , Au Sunny , Zhao Zhen , Shi Tian , Kan Daniel , Zhang Yang
Published: September 2024

The application of reinforced concrete modular integrated construction (MiC) has gained popularity in Hong Kong, but challenges still exist in the temporary tying of side walls during composite wall construction. This paper presents an innovative inner tie system for composite walls, applied in a MiC project in Hong Kong. The system’s components are installed on the side walls of precast modules in the factory without the need to penetrate through the walls. After transport to the site, by rotating the loop on-site to engage the hook, the tying effect is achieved during on-site concrete pouring between the interstitial space of two modules. This system eliminates the use of tie bolts that penetrate precast side walls, allowing for comprehensive interior fitting-out in the factory and minimizing disruptions to internal decoration during on-site construction. The paper presents the system’s mechanism, nonlinear Finite Element Analysis (FEA) simulation, section size optimization, and validation through tensile and punching shear tests. Furthermore, an instrumented mockup module assembly was carried out, and the system was eventually applied in a real MiC project. The system can effectively control the horizontal deformation of MiC module side walls within a limit. Compared to current existing tying methods, this system offers easy installation, load-bearing reliability, adaptability to certain construction errors, savings on manpower and construction time, and also a decrease in construction waste and carbon emission. It will provide a valuable reference for future MiC projects.
Recent Advances in Carbon-Based Interfacial Photothermal Converters for Seawater Desalination: A Review
Authors: Jia Xiaoyu , Niu Yuke , Zhu Shufang , He Hongwei , Yan Xu
Published: September 2024

Along with the rapid development of society, freshwater shortages have become a global concern. Although existing desalination technologies have alleviated this pressure to some extent, their long-term environmental impact and energy consumption are still questionable. Therefore, it is necessary to find a new effective way for seawater desalination with cleaner energy. Solar-driven interfacial water evaporation technology has the advantages of environmental protection, energy saving, high evaporation efficiency, low cost, and strong sustainability, and is considered one of the most effective technologies to relieve water resource stress. This review summarized the recent advances in carbon-based interfacial photothermal converters focused on the preparation methods of 2D and 3D photothermal absorbers, the potential ways to enhance the efficiency of photothermal conversion. Finally, this paper proposed the challenges and future trends of interfacial photothermal converters.
Risk Stratification by Combination of Heart and Lung Dose in Locally Advanced Non-Small-Cell Lung Cancer after Radiotherapy
Authors: Watanabe Yui , Koide Yutaro , Shimizu Hidetoshi , Aoyama Takahiro , Shindo Yurika , Hashimoto Shingo , Tachibana Hiroyuki , Kodaira Takeshi
Published: September 2024

Background/Objectives: Despite advancements in treatment for patients with unresectable locally advanced non-small cell lung cancer (LA-NSCLC), overall survival (OS) remains poor. The specific effects of varying heart and lung doses on OS in LA-NSCLC patients have not been thoroughly investigated, especially their combined impact on survival. This study aimed to examine the impact on OS of both individual and combined heart and lung doses in patients with LA-NSCLC treated with radiotherapy over a three-year follow-up period. Methods: A total of 120 patients who received definitive radiotherapy for LA-NSCLC (stage III, 92.5%) from January 2015 to January 2020 were retrospectively reviewed. The endpoint in this study was OS. Each patient was followed for a fixed period of three years. Results: Univariate Cox regression analysis showed that OS was significantly related to mean heart dose (MHD, hazard ratio [HR], 3.4 [1.8–6.3]; p < 0.001), pericardium V40 (HR, 3.2 [1.7–6.0]; p < 0.001), and total lung V20 (HR, 2.6 [1.4–5.0]; p = 0.003), and these were independent predictors for worse OS in multivariate analysis. Kaplan–Meier curve analysis with log-rank tests revealed that survival was significantly worse in patients with higher MHD (p < 0.001), pericardium V40 (p < 0.001), and total lung V20 (p = 0.002). Combining MHD and total lung V20, and pericardium V40 and total lung V20 provided enhanced risk stratification for OS (p < 0.001 for both combinations). Conclusions: The combination of heart and lung doses provided enhanced and more detailed risk stratification in prediction of OS for a fixed period of three years in LA-NSCLC patients treated with radiotherapy.
Correction: Russo et al. The Role of Dielectrophoresis for Cancer Diagnosis and Prognosis. Cancers 2022, 14, 198
Authors: Russo Giorgio Ivan , Musso Nicolò , Romano Alessandra , Caruso Giuseppe , Petralia Salvatore , Lanzanò Luca , Broggi Giuseppe , Camarda Massimo
Published: September 2024

Reference [...]
Altered Cytokine Secretory Fingerprint of the Adipocytes Derived from Stem Cells of Morbidly Obese Patients—A Preliminary Study
Authors: Łukaszuk Bartłomiej , Supruniuk Elżbieta , Chabowski Adrian , Mikłosz Agnieszka
Published: September 2024

Context: Adipose-derived mesenchymal stem cells (ADMSCs) are progenitor cells that shape the tissue’s biological properties. Objective: To examine the adipocytes differentiated from the ADMSCs of lean and obese individuals with/without a metabolic syndrome (MetSx) cytokine secretory profile, as to date, little is known on this topic. Methods: Interleukin, chemokine and growth factor levels in the culture medium were determined using the Human Cytokine kit. Results: We observed a characteristic secretory fingerprint displayed by the cells from the MetSx group and identified a set of putative markers (IL-1β, IL-6, IL-7, IL-10, IL-12, IL-13, VEGF, FGF, GM-CSF, TNF-α, IFN-γ) of the condition. Surprisingly, the concentrations of most of the molecules (except for IL-6, IFN-γ, IP-10, VEGF) decreased when compared with the cells from the lean group. We postulate that the difference stemmed from the fact that in vivo cytokines were mostly secreted by the activated monocytes/macrophages and not adipocytes per se. This may also suggest that the aforementioned upregulated cytokines (IL-6, IFN-γ, IP-10, VEGF) might have been the ones that attracted monocytes and triggered the vicious cycle of tissue inflammation. Conclusions: Our study indicated that the adipocytes newly derived from the ADMSCs of obese patients with metabolic syndrome displayed a secretory fingerprint that may be characteristic to the early stages of the condition.
Dysfunction of Telomeric Cdc13-Stn1-Ten1 Simultaneously Activates DNA Damage and Spindle Checkpoints
Authors: Grandin Nathalie , Charbonneau Michel
Published: September 2024

Telomeres, the ends of eukaryotic linear chromosomes, are composed of repeated DNA sequences and specialized proteins, with the conserved telomeric Cdc13/CTC1-Stn1-Ten1 (CST) complex providing chromosome stability via telomere end protection and the regulation of telomerase accessibility. In this study, SIZ1, coding for a SUMO E3 ligase, and TOP2 (a SUMO target for Siz1 and Siz2) were isolated as extragenic suppressors of Saccharomyces cerevisiae CST temperature-sensitive mutants. ten1-sz, stn1-sz and cdc13-sz mutants were isolated next due to being sensitive to intracellular Siz1 dosage. In parallel, strong negative genetic interactions between mutants of CST and septins were identified, with septins being noticeably sumoylated through the action of Siz1. The temperature-sensitive arrest in these new mutants of CST was dependent on the G2/M Mad2-mediated and Bub2-mediated spindle checkpoints as well as on the G2/M Mec1-mediated DNA damage checkpoint. Our data suggest the existence of yet unknown functions of the telomeric Cdc13-Stn1-Ten1 complex associated with mitotic spindle positioning and/or assembly that could be further elucidated by studying these new ten1-sz, stn1-sz and cdc13-sz mutants.
Treadmill Exercise Facilitates Synaptic Plasticity in APP/PS1 Mice by Regulating Hippocampal AMPAR Activity
Authors: Yu Laikang , Li Yan , Lv Yuanyuan , Gu Boya , Cai Jiajia , Liu Qing-Song , Zhao Li
Published: September 2024

Accumulating evidence underscores exercise as a straightforward and cost-effective lifestyle intervention capable of mitigating the risk and slowing the emergence and progression of Alzheimer’s disease (AD). However, the intricate cellular and molecular mechanisms mediating these exercise-induced benefits in AD remain elusive. The present study delved into the impact of treadmill exercise on memory retrieval performance, hippocampal synaptic plasticity, synaptic morphology, and the expression and activity of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptors (AMPARs) in 6-month-old APP/PS1 mice. APP/PS1 mice (4-month-old males) were randomly assigned to either a treadmill exercise group or a sedentary group, with C57BL/6J mice (4-month-old males) as the control group (both exercise and sedentary). The exercise regimen spanned 8 weeks. Our findings revealed that 8-week treadmill exercise reversed memory retrieval impairment in step-down fear conditioning in 6-month-old APP/PS1 mice. Additionally, treadmill exercise enhanced basic synaptic strength, short-term potentiation (STP), and long-term potentiation (LTP) of the hippocampus in these mice. Moreover, treadmill exercise correlated with an augmentation in synapse numbers, refinement of synaptic structures, and heightened expression and activity of AMPARs. Our findings suggest that treadmill exercise improves behavioral performance and facilitates synaptic transmission by increasing structural synaptic plasticity and the activity of AMPARs in the hippocampus of 6-month-old APP/PS1 mice, which is involved in pre- and postsynaptic processes.
Internalizing Symptoms and Their Impact on Patient-Reported Health-Related Quality of Life and Fatigue among Patients with Craniopharyngioma During Proton Radiation Therapy
Authors: Mandrell Belinda N. , Guo Yian , Li Yimei , Hancock Donna , Caples Mary , Ashford Jason M. , Merchant Thomas E. , Conklin Heather M. , Crabtree Valerie Mc.
Published: September 2024

Objective: The aim of this study was to describe fatigue, health-related quality of life (HRQOL) and brain tumor-associated symptoms after surgical resection and during proton radiotherapy, using latent class analysis (LCA), and to determine if there is class membership change among pediatric patients with craniopharyngioma. Methods: For all patients (n = 92), demographic and disease-related/clinical variables were attained, and patient reported outcomes were collected prior to proton therapy, at week three, and at the completion of proton therapy. The mean scores for fatigue, HRQOL, and brain tumor symptoms were compared over time and profiles were identified. Factors that influenced profile status and transition probability were examined. Results: Fatigue, HRQOL, and brain tumor symptoms improved over time during proton therapy; however, a subset remained in the lower profile, profile 1, associated with increased internalizing behaviors, compared to profile 2. Conclusions: Future study should explore the bidirectional relationship of sleep, worry and anxiety in the context of ongoing radiotherapy.
Association between Academic Performance, Physical Activity, and Academic Stress in Compulsory Secondary Education: An Analysis by Sex
Authors: Galeano-Rojas Dilan , Cuadros-Juárez Marina , León Reyes Borys Bismark , Castelo Reyna Mónica Alexandra , Farías-Valenzuela Claudio , Valdivia-Moral Pedro
Published: September 2024

Objectives: The main objective of this study is to analyze the relationships between academic performance, physical activity, and academic stress in secondary education students, while the secondary objective is to establish differences by gender in the physical activity and academic stress levels of secondary students based on academic performance. Methods: The sample was composed of students from both sexes who attended public institutions. Data collection was conducted applying an ad hoc questionnaire for academic performance, the PAQ-C questionnaire for physical activity, and the QASSE questionnaire for academic stress. Data analysis was performed using descriptive statistics: Spearman’s correlation coefficient was used for associations, while comparisons were conducted via the Mann–Whitney U test and Kruskal–Wallis H test. Results: The results show that academic stress is negatively correlated with physical activity and academic performance. Men present significantly higher values in physical activity, while women present higher mean values in general academic stress and the academic overload dimension. Lastly, regarding academic performance, significant differences were observed in the family pressure dimension, with students who perform better academically presenting lower mean values in this dimension of academic stress. Conclusions: In conclusion, the more the general academic stress, the lower the physical activity levels and academic performance. In addition, physical activity appears as a potential coping strategy for academic stress, and its influence on academic performance should be further studied in secondary education.
Reply to Herrmann et al. Comment on “van Gemert et al. Asymptomatic Infant Rib Fractures Are Primarily Non-abuse-Related and Should Not Be Used to Assess Physical Child Abuse. Children 2023, 10, 1827”
Authors: van Gemert Martin J. C. , Vlaming Marianne , Gabaeff Steven C. , Nikkels Peter G. J. , Neumann H. A. Martino
Published: September 2024

We thank the authors of [...]
Meningococcal Carriage in Children with Atypical Hemolytic Uremic Syndrome Receiving Eculizumab Therapy
Authors: Kavaz Tufan Asli , Ozak Batibay Fatma , Kaya Aksoy Gulsah , Gulhan Bora , Demircioglu Kilic Beltinge , Dursun Ismail , Buyukkaragoz Bahar , Caltik Yilmaz Aysun , Nalcacioglu Hulya , Becerir Tulay , Cetin Nuran , Celegen Kubra , Dinleyici Meltem , Kaya Mucahit , Kilic Omer , Dinleyici Ener Cagri
Published: September 2024

Background/Objectives: Eculizumab is a first-line treatment for atypical hemolytic uremic syndrome (aHUS), and patients undergoing eculizumab therapy may become more susceptible to infection caused by Neisseria meningitidis (Nm). While meningococcal vaccination is required for patients undergoing eculizumab therapy, there is limited knowledge about meningococcal carriage in children with aHUS. We aimed to evaluate (1) the prevalence of Nm carriage, (2) serogroup distribution, and (3) the immunization status of children undergoing eculizumab treatment for aHUS. Methods: The Meningo-aHUS study is a prospective, multi-center study evaluating meningococcal carriage in children and adolescents in Türkiye receiving eculizumab for aHUS. We noted the age, gender, daycare, school, or university attendance, passive smoking status, previous infection and antibiotic use, and previous immunization history, including meningococcal vaccines, from the medical records of those children with aHUS. We collected nasopharyngeal samples, tested them for Nm using real-time polymerase chain reaction, and performed a serogroup analysis on the positive samples. Results: We collected nasopharyngeal samples from 62 children with aHUS. Out of 62 children, 61 (98.4%) had received at least one dose of the meningococcal vaccine. The median time since the last meningococcal vaccine dose was 15 months (1–59 months). We detected meningococcal carriage in three (4.8%, 95% CI 1.0–13.5) children, and all three strains were non-groupable (NG). No other serogroups were detected. Conclusions: Almost all the children received their risk-group meningococcal immunization, including booster doses. A 4.8% of children with aHUS carried NG meningococci and, no vaccine serogroups were detected. Patients treated with eculizumab remain profoundly susceptible to IMD due to these NG meningococcal strains. The occurrence of breakthrough cases and carriage of Nm, especially NG strains, highlights the significance of maintaining a state of constant alertness, promptly seeking medical attention, and swiftly treating any symptoms that align with IMD, regardless of their vaccination status or antibiotic prophylaxis.
Preparation of Antistatic Polyester Fiber via Layer-by-Layer Self-Assembly
Authors: Wang Wei , Zhang Jialong , Liu Yifan , Weng Mengyun , Fu Yanchun
Published: September 2024

Polyester fibers tend to generate static electricity during the weaving and application processes, posing a threat to their production. Enhancing the water absorbency and electrical conductivity of polyester fibers themselves is an effective approach to improving their antistatic properties. In this study, multifunctional chitosan (CS), sodium phytate (SP), and Cu2+ were loaded on polyester fibers through layer-by-layer (LBL) self-assembly. The antistatic and water absorption capability of the modified polyester fibers was investigated by designing different process parameters combined with a surface resistance test and water contact angle tests. The antistatic property test results confirmed the positive effect of CS and Cu2+ on discharging electrostatic charge. Within a definite scope, with the increase in the number of assembly layers, assembly duration, and the concentration of the assembly substances, the wettability of the modified polyester fibers became more favorable and the antistatic effect became more remarkable.
Superhydrophobic Corrosion-Resistant Coating of AZ91D Magnesium Alloy: Preparation and Performance
Authors: Qi Shucheng , Liu Xiang , Cheng Lei , Zhu Jiyuan
Published: September 2024

This research presents the development of a surface treatment for AZ91D magnesium alloy that exhibits both superhydrophobic and anticorrosive properties. Initially, a zinc-based phosphate film was deposited on the magnesium alloy surface. Subsequently, a composite coating with superhydrophobic properties was produced by surface modification using a fluorosilane-ethanol solution. The composite coating’s microstructure, chemical composition, wettability, self-cleaning, and anti-corrosion properties were evaluated using scanning electron microscopy, a contact angle measurement instrument, and an electrochemical workstation. The results demonstrated that the main components of the composite coating were P, O, Zn, F, and C. The static contact angle reached 158°, providing superior self-cleaning and acid and alkali corrosion resistance. Additionally, the charge transfer resistance and coating resistance of the composite coating were significantly higher than those of the magnesium alloy substrate, effectively preventing corrosion and preserving the surface from fouling.
Dynamics of Blood Flows in the Cardiocirculatory System
Authors: D’Arienzo Maria Pia , Rarità Luigi
Published: September 2024

Models and simulations of blood flow in vascular networks are useful to deepen knowledge of cardiovascular diseases. This paper considers a model based on partial differential equations that mimic the dynamics of vascular networks in terms of flow velocities and arterial pressures. Such quantities are found by using ad hoc numerical schemes to examine variations in the pressure and homeostatic conditions of a whole organism. Two different case studies are examined. The former uses 15 arteries—a network that shows the real oscillations in pressures and velocities due to variations in artery volume. The latter focuses on the 55 principal arteries, and blood flows are studied by using a model of a heart valve that opens and closes via the differences in the aortic and left ventricle pressures. This last case confirms the possibility of autonomously regulating blood pressure and velocity in arteries in general and when tilt tests are applied to patients.
Comprehensive Overview of Long-Term Ecosystem Research Datasets at LTER Site Oberes Stubachtal
Authors: Zagel Bernhard , Wiesenegger Hans , Junker Robert R. , Ehgartner Gerhard
Published: September 2024

This article provides a comprehensive overview of all currently available datasets of the Long-term Ecosystem Research (LTER) site Oberes Stubachtal. The site is located in the Hohe Tauern mountain range (Eastern Alps, Austria) and includes both protected areas (Hohe Tauern National Park) and unprotected areas (Stubach valley). While the main research focus of the site is on high mountains, glaciology, glacial hydrology, and biodiversity, the eLTER Whole-System Approach (WAILS) was used for data selection. This approach involves a systematic screening of all available data to assess their suitability as eLTER Standard Observations (SOs). This includes the geosphere, atmosphere, hydrosphere, biosphere, and sociosphere. These SOs are fundamental to the development of a comprehensive long-term ecosystem research framework. In total, more than 40 datasets have been collated for the LTER site Oberes Stubachtal and included in the Dynamic Ecological Information Management System—Site and Data Registry (DEIMS-SDR), the eLTER’s data platform. This paper provides a detailed inventory of the datasets and their primary attributes, evaluates them against the WAILS-required observation data, and offers insights into strategies for future initiatives. All datasets are made available through dedicated repositories for FAIR (findable, accessible, interoperable, reusable) use.
Cross-Cultural Adaptation and Clinical Validation of the Mini Sarcopenia Risk Assessment Questionnaire in Community-Dwelling Spanish Older Adults
Authors: Moreno-Sánchez Inés , Aibar-Almazán Agustín , Carcelén-Fraile María del Carmen , Parra-Díaz Ana Belén , Sánchez-Montesinos García Indalecio , Sánchez-Alcalá Marcelina , Cano-Sánchez Javier , Hita-Contreras Fidel
Published: September 2024

(1) Background: The aim was to analyze the reliability and validity of the Spanish version of the Mini Sarcopenia Risk Assessment (MSRA) in older adults. (2) Methods: A total of 136 participants (72.24 ± 5.21 years, 68.38% women) took part in the study. The MSRA includes two questionnaires with seven (MSRA-7) and five items (MSRA-5). First, reliability (inter-rater and test–retest) of the Spanish MSRA was studied, and then the total scores were compared with the presence of sarcopenia according to three different diagnostic criteria and with other parameters related to sarcopenia (clinical validation). (3) Results: The analysis showed excellent inter-rater and test–retest reliability. As for the clinical validation, and regardless of the criteria, both questionnaires had a high sensitivity (81.82–88.89% for the MSRA-5 and 90.91–94.44% for the MSRA-7), while the MSRA-5 showed a better specificity (32.00–33.90%) than the MSRA-7 (20.80–22.88%). Predictive positive values ranged from 9.57–17.02% (MSRA-5) and 9.17–15.54% (MSRA-7), while predictive negative values were high for both the MSRA-5 (95.24%) and the MSRA-7 (96.30–96.43%). The accuracy was better for the MSRA-5 (36.03–41.18%) than the MSRA-7 (26.47–32.35%), as well as the area under the curve (0.67–0.76 vs. 0.65–0.73, respectively). Higher MSRA-5 and MSRA-7 total scores significantly correlated with greater muscle strength, quantity and gait speed. (4) Conclusions: The adaptation of the Spanish MSRA questionnaires was successfully performed, and they are reliable and clinically valid tools for assessing sarcopenia.
Evaluation of the Eazyplex® Candida ID LAMP Assay for the Rapid Diagnosis of Positive Blood Cultures
Authors: Berlau Arvid , Stoll Sylvia , Edel Birgit , Löffler Bettina , Rödel Jürgen
Published: September 2024

Rapid molecular assays can be used to identify Candida pathogens directly from positive blood cultures (BCs) in a timely manner compared to standard methods using subcultures. In this study, the eazyplex® Candida ID assay, which is based on loop-mediated amplification (LAMP) and is currently for research use only, was evaluated for the identification of the most common fungal species. A total of 190 BCs were analysed. Sensitivity and specificity were 93.88% and 99.26% for C. albicans, 89.13% and 100% for Nakaseomyces glabratus (N. glabratus), 100% and 100% for Pichia kudravzevii (P. kudriavzevii), 100% and 100% for C. tropicalis, and 100% and 99.44% for C. parapsilosis. Sample preparation took approximately 11 min and positive amplification results were obtained between 8.5 and 19 min. The eazyplex® Candida ID LAMP assay is an easy-to-use diagnostic tool that can optimise the management of patients with candidemia.
The Clinical Significance of Pancreatic Steatosis in Pancreatic Cancer: A Hospital-Based Study
Authors: Chan Chia-Hao , Chang Chia-Chen , Peng Yen-Chun
Published: September 2024

Background/Objectives: Pancreatic cancer remains one of the deadliest malignancies worldwide with a pressing need for early detection and intervention strategies. Emerging evidence has suggested a potential link between pancreas steatosis, characterized by excessive pancreatic fat accumulation, and an increased risk of pancreatic cancer development. This retrospective imaging study aims to elucidate the association between pancreatic steatosis and the subsequent development of pancreatic cancer. In the study, we aimed to determine the characteristics of pancreatic cancer with pancreatic steatosis. Methods: During the period of January 2022 to December 2022, we conducted a retrospective study, collecting 101 newly diagnosed pancreas cancer cases from the available image datasets. A comprehensive database of retrospective abdominal imaging studies, comprising computed tomography (CT) and magnetic resonance imaging (MRI), was established from a diverse patient population and subsequently analyzed. Inclusion criteria encompassed patients having available baseline imaging data, allowing for the assessment of pancreatic fat content. Pancreatic fat content was quantified using validated radiological techniques, while demographic, clinical, and histopathological data were all collected. The clinical data and patient characteristics were collected from medical records and analyzed. Results: Preliminary analysis revealed a significant correlation between elevated pancreatic fat content and an increased incidence of subsequent pancreatic cancer. Moreover, subgroup analysis based on age, gender, and comorbidities provided valuable insight into potential risk factors associated with this progression. Additionally, the study identified novel radiological markers that may serve as early indicators of pancreatic cancer development in individuals with pancreatic steatosis. Conclusions: In the imaging study, approximately 30% (30/101) of pancreatic cancer patients presented with pancreatic steatosis. Chronic pancreatitis emerged as the primary factor contributing to pancreatic steatosis in these patients. Importantly, pancreatic steatosis did not significantly impact the prognosis of pancreatic cancer. Follow-up data revealed no significant differences in survival duration between patients with or without pancreatic steatosis. Additionally, no association was found between pancreatic steatosis and hepatic steatosis.
The Impact of Vitamin D on Androgens and Anabolic Steroids among Adult Males: A Meta-Analytic Review
Authors: Abu-Zaid Ahmed , Saleh Saleh A. K. , Adly Heba M. , Baradwan Saeed , Alharran Abdullah M. , Alhatm Mshal , Alzayed Mooza M. , Alotaibi Muteb N. , Saad Abdulbadih Rabih , Alfayadh Hessa Mohammed , Abuzaid Mohammed , Alomar Osama
Published: September 2024

Background: Recent studies indicate that vitamin D impacts male reproductive function, with deficiency linked to infertility. This review evaluates the effect of vitamin D supplementation on male fertility, focusing on total testosterone, free testosterone, the free androgen index (FAI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex-hormone-binding globulin (SHBG), and estradiol. Methods: We systematically searched Medline, Web of Science, Cochrane Library, and Scopus from their inception until July 2024 for randomized controlled trials (RCTs) involving adult males. The primary focus of these studies was on reproductive hormone parameters, analyzed using a random-effects meta-analysis and weighted mean difference (WMD). Evidence quality was assessed using ROB2 and GRADE. Meta-regression and dose–response analyses were performed. Results: Seventeen studies met the criteria for quantitative analysis. Vitamin D supplementation significantly increased total testosterone levels (WMD 0.38, 95% CI 0.06–0.70, n = 15, I2 = 67.03). However, it had no significant effect on other hormone parameters: free testosterone (WMD 0.00, 95% CI −0.02–0.03, n = 9, I2 = 48.12), FSH (WMD −0.02, 95% CI −0.57–0.53, n = 7, I2 = 48.72), LH (WMD −0.09, 95% CI −0.30–0.12, n = 8, I2 = 0.00), SHBG (WMD 0.73, 95% CI −1.14–2.61, n = 10, I2 = 69.05), FAI (WMD −0.92, 95% CI −2.12–0.27, n = 6, I2 = 0.00), and estradiol (WMD −0.02, 95% CI −2.95–2.92, n = 5, I2 = 20.63). Conclusion: This meta-analysis shows that vitamin D supplementation may increase total testosterone levels in men. However, further well-designed RCTs are needed to determine vitamin D’s effects on other reproductive hormone parameters.
Laying Foundations for Islamic Teacher Education
Authors: Memon Nadeem A. , Abdalla Mohamad , Chown Dylan
Published: September 2024

Increasingly, educators committed to the vision of Islamic schooling are expressing sentiments of moral dissonance. On the one hand, they choose Islamic schools because they aspire to affect hearts, nurture whole human beings, and grow spiritually while impacting their learners’ sense of higher purpose. On the other hand, they are up against an era of globalised educational reform, characterised by neoliberal-engendered market forces and neoliberal policy logic that promote performativity and efficiency. This narrows what counts as learning, technicises the art of teaching, and assumes all learning that counts is visible and measurable. The teacher education and ongoing professional learning that educators working in Islamic schools have access to remains bifurcated. It is unable to address how an educator committed to tarbiya as “soul-making” ought to navigate aspirations with realities. This paper serves as the introduction to a special issue (SI) dedicated to conceptualising why Islamically grounded teacher education is needed and what it may entail. This SI will also offer empirical studies related to existing Islamic teacher education and professional learning programmes that capture essential reflections for a burgeoning subfield of Islamic Education Studies. In this introduction specifically, the co-editors and a co-author colleague make three big moves to lay the foundations for Islamic teacher education, including (1) establishing urgency for why Islamic teacher education is needed, (2) conceptualising what makes teacher education “Islamic”, and (3) providing an example of one Islamic teacher education programme’s attempt to advance a coherent professional learning journey for Islamic school educators. Together, these three moves serve as an attempt to redress bifurcation and advance a contextually relevant in-road to teacher education that is rooted in an Islamic paradigm and worldview while conversant with contemporary debates in education.
Social Trust Confirmation-Based Selfish Node Detection Algorithm in Socially Aware Networks
Authors: Chen Xiaowen , Rao Ying , Xiong Zenggang , Li Yuan , Zhang Xuemin , Hou Delin , Lou Qiangqiang , Li Jing
Published: September 2024

Nodes in socially aware networks (SANs) may act selfishly on individual bases due to resource constraints and socially selfish behavior arising from the social preferences of nodes. In response to such selfish behaviors exhibited by nodes, this paper proposes a social trust confirmation-based selfish node detection algorithm (STCDA). This algorithm first utilizes a subjective forwarding willingness detection mechanism to discern selfishness. If a node’s energy is insufficient or its message rejection rate is too high—that is, the node cannot or is unwilling to forward messages—it indicates that the node is selfish. Otherwise, it is evaluated more thoroughly through the node’s social trust detection mechanisms. It calculates the social trust level of nodes based on the benefits of forwarding messages, thereby distinguishing between individually selfish nodes and socially selfish nodes in the network. If further evaluation is needed, the final judgment will be made using the message confirmation feedback detection mechanism. This checks the message information forwarded by nodes in the network. If nodes fail to forward messages after receiving them—excluding reasons such as message expiration or temporary insufficient cache space—it indicates that the nodes are selfish. Results from experimental simulations show that this algorithm performs better than traditional algorithms. Under conditions of 80% selfish nodes, a message TTL of 300 min, and 10 MB of cache space, it improves the message delivery rate by 5.87% and reduces the average delay by 6.2% compared to the existing comprehensive confirmation-based selfish node detection algorithm.