bluuebunny/crossref_metadata_2025 huggingface dataset:
Kinetic and Thermodynamic Studies on Synthesis of Mg-Doped LiMn2O4 Nanoparticles
Authors: Llusco Aleksei , Grageda Mario , Ushak Svetlana
Published: July 2020

In this work, a first study on kinetics and thermodynamics of thermal decomposition for synthesis of doped LiMn2O4 nanoparticles is presented. The effect of Mg doping concentration on thermal decomposition of synthesis precursors, prepared by ultrasound-assisted Pechini-type sol–gel process, and its significance on nucleation and growth of Mg-doped LiMn2O4 nanoparticles was studied through a method based on separation of multistage processes in single-stage reactions by deconvolution and transition state theory. Four zones of thermal decomposition were identified: Dehydration, polymeric matrix decomposition, carbonate decomposition and spinel formation, and spinel decomposition. Kinetic and thermodynamic analysis focused on the second zone. First-order Avrami-Erofeev equation was selected as reaction model representing the polymer matrix thermal decomposition. Kinetic and thermodynamic parameters revealed that Mg doping causes an increase in thermal inertia on conversion rate, and CO2 desorption was the limiting step for formation of thermodynamically stable spinel phases. Based on thermogravimetry experiments and the effect of Mg on thermal decomposition, an optimal two-stage heat treatment was determined for preparation of LiMgxMn2−xO4 (x = 0.00, 0.02, 0.05, 0.10) nanocrystalline powders as promising cathode materials for lithium-ion batteries. Crystalline structure, morphology, and stoichiometry of synthesized powders were characterized by XRD, FE-SEM, and AAS, respectively.
A Polarization-Insensitive and Wide-Angle Terahertz Absorber with Ring-Porous Patterned Graphene Metasurface
Authors: Shen Hongyang , Liu Fengxiang , Liu Chunyang , Zeng Dong , Guo Banghong , Wei Zhongchao , Wang Faqiang , Tan Chunhua , Huang Xuguang , Meng Hongyun
Published: July 2020

A broadband terahertz (THz) absorber, based on a graphene metasurface, which consists of a layer of ring-porous patterned structure array and a metallic mirror separated by an ultrathin SiO2 dielectric layer, is proposed and studied by numerical simulation. The simulated results show that the absorptivity of the absorber reaches 90% in the range of 0.91–1.86 THz, and the normalized bandwidth of the absorptivity is 68.6% under normal incidence. In the simulation, the effects of the geometric parameters of the structure on the absorption band have been investigated. The results show that the absorber is insensitive to the incident polarization angle for both transverse electric (TE) and transverse magnetic (TM) under normal incidence. In addition, the absorber is not sensitive to oblique incidence of the light source under TE polarization conditions, and has an approximately stable absorption bandwidth at the incident angle from 0° to 50°. The absorption band can be adjusted by changing the bias voltage of the graphene Fermi level without varying the nanostructure. Furthermore, we propose that a two-layer graphene structure with the same geometric parameters is separated by a dielectric layer of appropriate thickness. The simulated results show that the absorptivity of the two-layer absorber reaches 90% in the range of 0.83-2.04 THz and the normalized bandwidth of the absorptivity is 84.3% under normal incidence. Because of its excellent characteristics based on graphene metamaterial absorbers, it has an important application value in the field of subwavelength photonic devices.
Kinetics of Hydrogen Generation from Oxidation of Hydrogenated Silicon Nanocrystals in Aqueous Solutions
Authors: Mussabek Gauhar , Alekseev Sergei A. , Manilov Anton I. , Tutashkonko Sergii , Nychyporuk Tetyana , Shabdan Yerkin , Amirkhanova Gulshat , Litvinenko Sergei V. , Skryshevsky Valeriy A. , Lysenko Vladimir
Published: July 2020

Hydrogen generation rate is one of the most important parameters which must be considered for the development of engineering solutions in the field of hydrogen energy applications. In this paper, the kinetics of hydrogen generation from oxidation of hydrogenated porous silicon nanopowders in water are analyzed in detail. The splitting of the Si-H bonds of the nanopowders and water molecules during the oxidation reaction results in powerful hydrogen generation. The described technology is shown to be perfectly tunable and allows us to manage the kinetics by: (i) varying size distribution and porosity of silicon nanoparticles; (ii) chemical composition of oxidizing solutions; (iii) ambient temperature. In particular, hydrogen release below 0 °C is one of the significant advantages of such a technological way of performing hydrogen generation.
Randomised Controlled Trial: Partial Hydrolysation of Casein Protein in Milk Decreases Gastrointestinal Symptoms in Subjects with Functional Gastrointestinal Disorders
Authors: Laatikainen Reijo , Salmenkari Hanne , Sibakov Timo , Vapaatalo Heikki , Turpeinen Anu
Published: July 2020

Unspecific gastrointestinal symptoms associated with milk consumption are common. In addition to lactose, also other components of milk may be involved. We studied whether the partial hydrolysation of milk proteins would affect gastrointestinal symptoms in subjects with functional gastrointestinal disorders. In a randomised, placebo-controlled crossover intervention, subjects (n = 41) were given ordinary or hydrolysed high-protein, lactose-free milkshakes (500 mL, 50 g protein) to be consumed daily for ten days. After a washout period of ten days, the other product was consumed for another ten days. Gastrointestinal symptoms were recorded daily during the study periods, and a validated irritable bowel syndrome-symptom severity scale (IBS-SSS) questionnaire was completed at the beginning of the study and at the end of both study periods. Blood and urine samples were analysed for markers of inflammation, intestinal permeability and immune activation. Both the IBS-SSS score (p = 0.001) and total symptom score reported daily (p = 0.002) were significantly reduced when participants consumed the hydrolysed product. Less bloating was reported during both study periods when compared with the baseline (p < 0.01 for both groups). Flatulence (p = 0.01) and heartburn (p = 0.03) decreased when consuming the hydrolysed product but not when drinking the control product. No significant differences in the levels of inflammatory markers (tumor necrosis factor alpha, TNF-α and interleukin 6, IL-6), intestinal permeability (fatty acid binding protein 2, FABP2) or immune activation (1-methylhistamine) were detected between the treatment periods. The results suggest that the partial hydrolysation of milk proteins (mainly casein) reduces subjective symptoms to some extent in subjects with functional gastrointestinal disorders. The mechanism remains to be resolved.
Effects on Gastroesophageal Reflux of Donkey Milk-Derived Human Milk Fortifier Versus Standard Fortifier in Preterm Newborns: Additional Data from the FortiLat Study
Authors: Cresi Francesco , Maggiora Elena , Pirra Alice , Tonetto Paola , Rubino Carlotta , Cavallarin Laura , Giribaldi Marzia , Moro Guido E. , Peila Chiara , Coscia Alessandra
Published: July 2020

Background: Feeding intolerance is a frequent diagnosis in very preterm infants. As seen in the FortiLat trial, human milk fortification with the new donkey milk-derived human milk fortifier (DF) seems to improve feeding tolerance in these infants. The aim of this study was to evaluate the effects of using the DF compared with bovine milk-derived fortifier (BF) on gastroesophageal reflux (GER) in very low birth weight (VLBW) infants. Methods: Over a total of 156 preterm infants were enrolled into the FortiLat trial (GA <32 weeks and birth weight <1500 g) and randomized into the BF arm or DF arm, and we selected all infants with clinical signs of GER and cardiorespiratory (CR) symptoms. All the infants underwent CR and multichannel intraluminal impedance and pH (MII/pH) monitoring associated with gastric ultrasound to evaluate GER and gastric emptying time. Results: 10 infants were enrolled, and 5 were in the DF arm. At MII/pH, infants enrolled into the DF arm showed a lower GER frequency than BF arm infants (p = 0.036). Half gastric emptying time was similar in DF and BF arm infants (p = 0.744). Conclusion: The use of donkey-derived human milk fortifier reduced the GER frequency and consequently should be recommended in infants with feeding intolerance.
Choline: An Essential Nutrient for Skeletal Muscle
Authors: Moretti Antimo , Paoletta Marco , Liguori Sara , Bertone Matteo , Toro Giuseppe , Iolascon Giovanni
Published: July 2020

Background: Choline is an essential micronutrient with a pivotal role in several metabolic pathways contributing to liver, neurological, and hematological homeostasis. Although choline is commonly administered to improve physical performance, its effects on muscle are still unclear. The aim of this scoping review is to analyze the role of choline on skeletal muscle in terms of biological effects and clinical implications. Methods: A technical expert panel (TEP) of 6 medical specialists with expertise in muscle physiology and skeletal muscle disorders performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP planned a research on PubMed selecting “choline” as MeSH (Medical Subject Headings) term adding to PubMed Search Builder the terms ”skeletal muscle” and “muscle striated”. TEP considered for eligibility articles published in the last 30 years, including original researches, particularly in vitro studies, and animal and clinical studies in the English language. Results: From the 1239 studies identified, TEP included 14 studies, 3 in vitro, 9 animal, and 2 clinical studies. Conclusions: Our scoping review elucidates and summarizes the crucial role of choline in modulating muscle fat metabolism, muscle proteins homeostasis, and the modulation of inflammation and autophagy.
Eating Competence among a Select Sample of Brazilian Adults: Translation and Reproducibility Analyses of the Satter Eating Competence Inventory
Authors: Queiroz Fabiana Lopes Nalon de , Nakano Eduardo Yoshio , Cortez Ginani Verônica , Botelho Raquel Braz Assunção , Araújo Wilma Maria Coelho , Zandonadi Renata Puppin
Published: July 2020

This study aimed to translate and validate the Satter Eating Competence Inventory (ecSI2.0TM) from English to Brazilian Portuguese. The process included three steps: (i) translation and back-translation of the original ecSI2.0TM to Brazilian Portuguese; (ii) evaluation of its reproducibility; (iii) a pilot study to validate the Brazilian version of the Satter Eating Competence Inventory (ecSI2.0TMBR) for a selected sample of the Brazilian adult population (internal consistency and factor validity). The reproducibility (test–retest reliability) was verified using the intraclass correlation coefficient (ICC) obtained by the responses of 32 Brazilian adults. All domains of the ecSI2.0TMBR and the total score showed ICC > 0.8. Considering the entire questionnaire, none of the domains presented significant divergences among the participants’ responses (p < 0.001). In the pilot study with 662 individuals, 74.9% (n= 496) were female, mean age was 40.33 ± 12.55, and they presented a higher level of schooling and income. Analyses revealed Cronbach’s alpha coefficients of 0.869 for the ecSI2.0TMBR total scale, 0.793 for Eating Attitudes, 0.527 for Internal Regulation, 0.728 for Food Acceptance, and 0.822 for Contextual Skills. In general, the ecSI2.0™BR presented good acceptability, showing total floor and ceiling effects of ≤0.6%. Factor validity was examined by confirmatory factor analysis. The four domains presented a good fit in the confirmatory factor analysis: RMSEA = 0.0123 (95% CI: 0–0.0266); CFI = 0.998; χ2 = 75.9; df = 69; p = 0.266. The ecSI2.0TMBR is the first tool designed to measure eating competence (EC) in the Brazilian population, showing good reproducibility and internal consistency. We expect the ecSI2.0TMBR will support innovative research to investigate the association of EC and health outcomes, as well as new strategies based on emerging behavioral theories to enhance nutritional education policy.
Thymocid®, a Standardized Black Cumin (Nigella sativa) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells
Authors: Li Huifang , DaSilva Nicholas A. , Liu Weixi , Xu Jialin , Dombi George W. , Dain Joel A. , Li Dongli , Chamcheu Jean Christopher , Seeram Navindra P. , Ma Hang
Published: July 2020

Black cumin (Nigella sativa) seed extract has been shown to improve dermatological conditions, yet its beneficial effects for skin are not fully elucidated. Herein, Thymocid®, a chemically standardized black cumin seed extract, was investigated for its cosmeceutical potential including anti-aging properties associated with modulation of glycation, collagen cross-linking, and collagenase and elastase activities, as well as antimelanogenic effect in murine melanoma B16F10 cells. Thymocid® (50, 100, and 300 µg/mL) inhibited the formation of advanced glycation end-products (by 16.7–70.7%), collagen cross-linking (by 45.1–93.3%), collagenase activity (by 10.4–92.4%), and elastases activities (type I and III by 25.3–75.4% and 36.0–91.1%, respectively). In addition, Thymocid® (2.5–20 µg/mL) decreased melanin content in B16F10 cells by 42.5–61.6% and reduced cellular tyrosinase activity by 20.9% (at 20 µg/mL). Furthermore, Thymocid® (20 µg/mL for 72 h) markedly suppressed the mRNA expression levels of melanogenesis-related genes including microphthalmia-associated transcription factor (MITF), tyrosinase-related protein 1 (TYRP1), and TYRP2 to 78.9%, 0.3%, and 0.2%, respectively. Thymocid® (10 µg/mL) also suppressed the protein expression levels of MITF (by 15.2%) and TYRP1 (by 97.7%). Findings from this study support the anti-aging and antimelanogenic potential of Thymocid® as a bioactive cosmeceutical ingredient for skin care products.
A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice
Authors: Guantario Barbara , Giribaldi Marzia , Devirgiliis Chiara , Finamore Alberto , Colombino Elena , Capucchio Maria Teresa , Evangelista Rocchina , Motta Vincenzo , Zinno Paola , Cirrincione Simona , Antoniazzi Sara , Cavallarin Laura , Roselli Marianna
Published: July 2020

Ageing is often characterised by nutritional deficiencies and functional alterations of the digestive and immune system. The aim of the present study was to analyse the impact of consumption of conventional milk with A1/A2 beta-casein, compared to milk containing only the A2 beta-casein variant, characterised by a protein profile favouring gut health. Twenty-four ageing Balb-c mice (20 months old) were fed for 4 weeks, with either a control diet (CTRL), a diet supplemented with bovine milk containing A1/A2 beta-casein (A1A2) or a diet containing A2/A2 beta-casein (A2A2). Lymphocyte subpopulations, enzymatic activities, cytokine secretion, gut morphology and histopathological alterations were measured in different gut segments, while short-chain fatty acids (SCFAs) content and microbiota composition were evaluated in faecal samples. The A2A2 group showed higher content of faecal SCFAs (in particular, isobutyrate) of intestinal CD4+ and CD19+ lymphocytes in the intraepithelial compartment and improved villi tropism. The A1A2 group showed higher percentages of intestinal TCRγδ+ lymphocytes. Faecal microbiota identified Deferribacteriaceae and Desulfovibrionaceae as the most discriminant families for the A2A2 group, while Ruminococcaceae were associated to the A1A2 group. Taken together, these results suggest a positive role of milk, in particular when containing exclusively A2 beta-casein, on gut immunology and morphology of an ageing mice model.
Changes in the Dietary Habits of the Greek EPIC Cohort Participants during a 14-Year Follow-Up Period (1997–2011)
Authors: Skourlis Nikolaos , Patsis Ioannis , Martimianaki Georgia , Peppa Eleni , Trichopoulou Antonia , Katsouyanni Klea
Published: July 2020

The aim of this study is to evaluate the changes in the nutritional behavior of the Greek EPIC (European Prospective Investigation into Cancer and Nutrition) cohort participants regarding the consumption of basic food groups, during a 14-year period (1997–2011). In the Greek segment of the EPIC cohort study (EPIC-Greece), the changes in dietary habits of 23,505 participants regarding several food items/groups (vegetables, legumes, fruits, nuts, dairy, cereal, meat, fish/seafood, olive oil) were recorded repeatedly over time and compared to the baseline assessment (1994–1997), using a short, qualitative, follow-up questionnaire. Descriptive statistics were used to study the trends in nutritional behavior over time and ordinal logistic regression models to study the associations between the ordered responses of the questionnaire and sociodemographic and health factors. More participants reported an increase rather than a decrease in the consumption of vegetables, fruits, fish/seafood, whilst the inverse was observed for dairy products, nuts, cereals, and meat. No prevailing trend was noted for legumes and olive oil. Factors such as being female and having high education relate to more positive (healthy) changes in nutritional behavior. There seems to be primarily a change to a more healthy nutritional behavior of the EPIC-Greece participants over the follow-up period, with different participant subgroups presenting different degrees of nutritional changes.
Do Parent–Child Dyads with Excessive Body Mass Differ from Dyads with Normal Body Mass in Perceptions of Obesogenic Environment?
Authors: Zarychta Karolina , Banik Anna , Kulis Ewa , Boberska Monika , Radtke Theda , Chan Carina K. Y. , Lobczowska Karolina , Luszczynska Aleksandra
Published: July 2020

Background: This study addressed differences between parent–child dyads with excessive body mass (overweight or obesity) and dyads with normal body mass in obesity determinants, derived from social-ecological models. It was hypothesized that parents and their 5–11 years-old children with excessive body mass would (1) report lower availability of healthy food at home, (2) perceive fewer school/local community healthy eating promotion programs, (3) report lower persuasive value of food advertising. Methods: Data were collected twice (T1, baseline; T2, 10-month follow-up), including n = 129 parent–child dyads with excessive body mass and n = 377 parent–child dyads with normal body mass. Self-reported data were collected from parents and children; with body weight and height assessed objectively. General linear models (including analysis of variance with repeated measures) were performed to test the hypotheses. Results: Compared to dyads with normal body mass, dyads of parents and children with excessive body mass perceived lower availability of healthy food at home and fewer healthy eating promotion programs at school/local community (T1 and T2). These effects remained significant after controlling for sociodemographic variables. No significant differences in persuasive value of food advertising were found. Conclusions: Perceptions of availability of healthy food at home and healthy nutrition promotion may be relatively low in parent–child dyads with excessive weight which, in turn, may constitute a risk factor for maintenance of obesity.
Consumer Misuse of Country-of-Origin Label: Insights from the Italian Extra-Virgin Olive Oil Market
Authors: Bimbo Francesco , Roselli Luigi , Carlucci Domenico , de Gennaro Bernardo Corrado
Published: July 2020

Providing information to consumers through the label is a means for food companies to inform consumers about product’s attributes, including the country of origin (COO). In the EU, COO labeling has been made mandatory for several categories of food products, to enable consumers to make informed choices at the point of sale. In particular, Regulation (EU) No 29/2012 has introduced a mandatory country-of-origin labeling system for extra virgin olive oil (EVOO). In the present study, conducted in Italy, we test whether there is a price differential associated with the COO information for EVOO. To this end, we employ a hedonic price model and data about the purchase of EVOO products collected from 982 consumers at the supermarket checkout. Having interviewed these consumers, we also assess the share of EVOO consumers that correctly identify the country of origin of the product purchased. Our findings point out that, in Italy, the EVOO with domestic origin, indicated on the label, benefits of a premium price equal to +35% compared to the product labeled as blend of European EVOOs, while a discount of −10.8% is attached to EVOOs from a non-European origin. A significant share of consumers in our sample (19.04%) is, however, unable to correctly identify the origin of the EVOO purchased. This label misuse mostly occurs among consumers who report that they had purchased Italian EVOO, while they had actually purchased a blend of European EVOOs. Female and more highly educated consumers are less likely to misuse label information about the product’s origins.
Serum Scoring and Quantitative Magnetic Resonance Imaging in Intestinal Failure-Associated Liver Disease: A Feasibility Study
Authors: Fragkos Konstantinos C. , Picasso Bouroncle María Claudia , Kumar Shankar , Caselton Lucy , Menys Alex , Bainbridge Alan , Taylor Stuart A. , Torrealdea Francisco , Kumagai Tomoko , Di Caro Simona , Rahman Farooq , Macnaughtan Jane , Chouhan Manil D. , Mehta Shameer
Published: July 2020

(1) Background: Intestinal failure-associated liver disease (IFALD) in adults is characterized by steatosis with variable progression to fibrosis/cirrhosis. Reference standard liver biopsy is not feasible for all patients, but non-invasive serological and quantitative MRI markers for diagnosis/monitoring have not been previously validated. Here, we examine the potential of serum scores and feasibility of quantitative MRI used in non-IFALD liver diseases for the diagnosis of IFALD steatosis; (2) Methods: Clinical and biochemical parameters were used to calculate serum scores in patients on home parenteral nutrition (HPN) with/without IFALD steatosis. A sub-group underwent multiparameter quantitative MRI measurements of liver fat fraction, iron content, tissue T1, liver blood flow and small bowel motility; (3) Results: Compared to non-IFALD (n = 12), patients with IFALD steatosis (n = 8) demonstrated serum score elevations in Enhanced Liver Fibrosis (p = 0.032), Aspartate transaminase-to-Platelet Ratio Index (p < 0.001), Fibrosis-4 Index (p = 0.010), Forns Index (p = 0.001), Gamma-glutamyl transferase-to-Platelet Ratio Index (p = 0.002) and Fibrosis Index (p = 0.001). Quantitative MRI scanning was feasible in all 10 sub-group patients. Median liver fat fraction was higher in IFALD steatosis patients (10.9% vs 2.1%, p = 0.032); other parameter differences were non-significant; (4) Conclusion: Serum scores used for non-IFALD liver diseases may be useful in IFALD steatosis. Multiparameter MRI is feasible in patients on HPN.
Psychological Aspects and Eating Habits during COVID-19 Home Confinement: Results of EHLC-COVID-19 Italian Online Survey
Authors: Di Renzo Laura , Gualtieri Paola , Cinelli Giulia , Bigioni Giulia , Soldati Laura , Attinà Alda , Bianco Francesca Fabiola , Caparello Giovanna , Camodeca Vanessa , Carrano Elena , Ferraro Simona , Giannattasio Silvia , Leggeri Claudia , Rampello Tiziana , Lo Presti Laura , Tarsitano Maria Grazia , De Lorenzo Antonino
Published: July 2020

The COVID-19 pandemic has had a huge impact on the population with consequences on lifestyles. The aim of the study was to analyse the relationship between eating habits, mental and emotional mood. A survey was conducted online during social isolation, from 24 April to 18 May 2020, among the Italian population. A total of 602 interviewees were included in the data analysis. A high percentage of respondents experienced a depressed mood, anxious feelings, hypochondria and insomnia (61.3%, 70.4%, 46.2% and 52.2%). Almost half of the respondents felt anxious due to the fact of their eating habits, consumed comfort food and were inclined to increase food intake to feel better. Age was inversely related to dietary control (OR = 0.971, p = 0.005). Females were more anxious and disposed to comfort food than males (p < 0.001; p < 0.001). A strength of our study was represented by the fact that the survey was conducted quickly during the most critical period of the Italian epidemic lockdown. As the COVID-19 pandemic is still ongoing, our data need to be confirmed and investigated in the future with larger population studies.
Low-Glycemic-Index/Load Desserts Decrease Glycemic and Insulinemic Response in Patients with Type 2 Diabetes Mellitus
Authors: Argiana Vasiliki , Kanellos Panagiotis , Eleftheriadou Ioanna , Tsitsinakis Georgios , Perrea Despoina , Tentolouris Nikolaos
Published: July 2020

Diabetes mellitus is a chronic disease whose prevalence is growing worldwide. Consumption of desserts with low glycemic index (GI) and low glycemic load (GL) in a balanced hypocaloric diet has a positive impact on anthropometric and metabolic parameters in patients with type 2 diabetes mellitus (T2DM). The aim of the present study was to evaluate the glycemic and insulinemic response after consumption of desserts with low GI/GL in patients with T2DM. Fifty-one patients consumed either 83 g of the conventional dessert or 150 g of the low GI/GL dessert in random order after an overnight fast. Serum glucose, triglycerides, and insulin were measured at baseline (immediately before ingestion) and at 30, 60, 90, and 120 min postprandially. Subjective appetite measurements were performed using visual analog scales (VASs). There were significant differences at 30 (p = 0.014), 60 (p < 0.001), and 90 min (p < 0.001) postprandially between the two desserts for glucose and at 30 (p = 0.014) and 60 min (p = 0.033) postprandially for insulin. Glucose iAUC was significantly lower in low-GI/GL dessert compared to control (p < 0.001). Serum triglycerides and insulin iAUC did not differ between the two trials. Fullness VAS ratings were significantly higher after consumption of the low-GI/GL dessert compared to conventional dessert. Likewise, hunger, additional food, and additional food quantity VAS ratings were significantly lower after the consumption of the low-GI/GL dessert compared to control. Consumption of low-GI/GL dessert indicates a positive impact on metabolic parameters in T2DM patients.
Bone Status in Patients with Phenylketonuria: A Systematic Review
Authors: de Castro María José , de Lamas Carmela , Sánchez-Pintos Paula , González-Lamuño Domingo , Couce María Luz
Published: July 2020

Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism. Although dietary and, in some cases, pharmacological treatment has been successful in preventing intellectual disability in PKU patients who are treated early, suboptimal outcomes have been reported, including bone mineral disease. In this systematic review, we summarize the available evidence on bone health in PKU patients, including data on bone mineral density (BMD) and bone turnover marker data. Data from cohort and cross-sectional studies of children and adults (up to 40 years of age) were obtained by searching the MEDLINE and SCOPUS databases following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. For each selected study, quality assessment was performed applying the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS I) tool. We found that mean BMD was lower in PKU patients than in reference groups, but was within the normal range in most patients when expressed as Z-score values. Furthermore, data revealed a trend towards an imbalance between bone formation and bone resorption, favoring bone removal. Data on serum levels of minerals and hormones involved in bone metabolism were very heterogeneous, and the analyses were inconclusive. Clinical trials that include the analysis of fracture rates, especially in older patients, are needed to gather more evidence on the clinical implications of lower BMD in PKU patients.
Effects of Pistachio Consumption in a Behavioral Weight Loss Intervention on Weight Change, Cardiometabolic Factors, and Dietary Intake
Authors: Rock Cheryl L. , Zunshine Elizabeth , Nguyen Huong Thien , Perez Annemarie O. , Zoumas Christine , Pakiz Bilge , White Martha M.
Published: July 2020

Epidemiological studies have linked regular nut consumption with lower body mass index and reduced likelihood of weight gain in adulthood. Nuts can displace other foods in the diet, and thus, promote a healthier dietary pattern. The purpose of this study was to examine the effect of pistachio nut consumption in overweight/obese adults. This randomized controlled study enrolled non-diabetic overweight/obese adults (n = 100) assigned to a 4-month behavioral weight loss intervention only group (controls) or also prescribed 1.5 oz/day (42 g/day) of pistachios (pistachio group). Outcomes were change in body weight, cardiometabolic factors, and dietary intake. Percent weight change was similar in the two groups (−5.1 [0.5] (mean [SE])% in the control group and −4.9 [0.6]% in the pistachio group, and body mass index (BMI) and waist circumference were reduced in both groups (time effect p ≤ 0.05). The pistachio group (but not the control group) exhibited a significant reduction in both systolic and diastolic blood pressure (time effect p = 0.01). Plasma alpha-carotene, beta-carotene, and lutein concentrations increased significantly in the pistachio group (time effect p < 0.05). Pistachio consumption was associated with increased dietary fiber intake and decreased consumption of sweets. Regular consumption of pistachios was associated with a comparable degree of weight loss, and similar reductions in BMI and waist circumference, in overweight/obese men and women compared to controls, and favorable changes in the diet, in the context of a behavioral weight loss intervention.
Plant Food, Nutrition, and Human Health
Authors: Mena Pedro , Angelino Donato
Published: July 2020

Phytochemical compounds are non-nutrient secondary metabolites present in plant-based foods, e [...]
Identification of Antimicrobial Resistance-Associated Genes through Whole Genome Sequencing of Mycoplasma bovis Isolates with Different Antimicrobial Resistances
Authors: Ledger Lisa , Eidt Jason , Cai Hugh Y.
Published: July 2020

Antimicrobial resistance (AMR) in Mycoplasma bovis has been previously associated with topoisomerase and ribosomal gene mutations rather than specific resistance-conferring genes. Using whole genome sequencing (WGS) to identify potential new AMR mechanisms for M. bovis, it was found that a 2019 clinical isolate with high MIC (2019-043682) for fluoroquinolones, macrolides, lincosamides, pleuromutilins and tetracyclines had a new core genome multilocus sequencing (cgMLST) type (ST10-like) and 91% sequence similarity to the published genome of M. bovis PG45. Closely related to PG45, a 1982 isolate (1982-M6152) shared the same cgMLST type (ST17), 97.2% sequence similarity and low MIC results. Known and potential AMR- associated genetic events were identified through multiple sequence alignment of the three genomes. Isolate 2019-043682 had 507 genes with non-synonymous mutations (NSMs) and 67 genes disrupted. Isolate 1982-M6152 had 81 NSMs and 20 disruptions. Using functional roles and known mechanisms of antimicrobials, a 55 gene subset was assessed for AMR potential. Seventeen were previously identified from other bacteria as sites of AMR mutation, 38 shared similar functions to them, and 11 contained gene-disrupting mutations. This study indicated that M. bovis may obtain high AMR characteristics by mutating or disrupting other functional genes, in addition to topoisomerases and ribosomal genes.
Lipoxygenase Inhibition Activity of Coumarin Derivatives—QSAR and Molecular Docking Study
Authors: Lončarić Melita , Strelec Ivica , Pavić Valentina , Šubarić Domagoj , Rastija Vesna , Molnar Maja
Published: July 2020

Lipoxygenases (LOXs) are a family of enzymes found in plants, mammals, and microorganisms. In animals and plants, the enzyme has the capability for the peroxidation of unsaturated fatty acids. Although LOXs participate in the plant defense system, the enzyme’s metabolites can have numerous negative effects on human health. Therefore, many types of research are searching for compounds that can inhibit LOXs. The best quantitative structure–activity relationship (QSAR) model was obtained using a Genetic Algorithm (GA). Molecular docking was performed with iGEMDOCK. The inhibition of lipoxygenase was in the range of 7.1 to 96.6%, and the inhibition of lipid peroxidation was 7.0–91.0%. Among the synthesized compounds, the strongest inhibitor of soybean LOX-3 (96.6%) was found to be 3-benzoyl-7-(benzyloxy)-2H-chromen-2-one. A lipid peroxidation inhibition of 91.0% was achieved with ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate. The docking scores for the soybean LOX-3 and human 5-LOX also indicated that this compound has the best affinity for these LOX enzymes. The best multiple linear QSAR model contains the atom-centered fragment descriptors C-06, RDF035p, and HATS8p. QSAR and molecular docking studies elucidated the structural features important for the enhanced inhibitory activity of the most active compounds, such as the presence of the benzoyl ring at the 3-position of coumarin’s core. Compounds with benzoyl substituents are promising candidates as potent lipoxygenase inhibitors.
Autophagy as a Potential Therapy for Malignant Glioma
Authors: Escamilla-Ramírez Angel , Castillo-Rodríguez Rosa A. , Zavala-Vega Sergio , Jimenez-Farfan Dolores , Anaya-Rubio Isabel , Briseño Eduardo , Palencia Guadalupe , Guevara Patricia , Cruz-Salgado Arturo , Sotelo Julio , Trejo-Solís Cristina
Published: July 2020

Glioma is the most frequent and aggressive type of brain neoplasm, being anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM), its most malignant forms. The survival rate in patients with these neoplasms is 15 months after diagnosis, despite a diversity of treatments, including surgery, radiation, chemotherapy, and immunotherapy. The resistance of GBM to various therapies is due to a highly mutated genome; these genetic changes induce a de-regulation of several signaling pathways and result in higher cell proliferation rates, angiogenesis, invasion, and a marked resistance to apoptosis; this latter trait is a hallmark of highly invasive tumor cells, such as glioma cells. Due to a defective apoptosis in gliomas, induced autophagic death can be an alternative to remove tumor cells. Paradoxically, however, autophagy in cancer can promote either a cell death or survival. Modulating the autophagic pathway as a death mechanism for cancer cells has prompted the use of both inhibitors and autophagy inducers. The autophagic process, either as a cancer suppressing or inducing mechanism in high-grade gliomas is discussed in this review, along with therapeutic approaches to inhibit or induce autophagy in pre-clinical and clinical studies, aiming to increase the efficiency of conventional treatments to remove glioma neoplastic cells.
Distinguishing Glaciers between Surging and Advancing by Remote Sensing: A Case Study in the Eastern Karakoram
Authors: Lv Mingyang , Guo Huadong , Yan Jin , Wu Kunpeng , Liu Guang , Lu Xiancai , Ruan Zhixing , Yan Shiyong
Published: July 2020

The Karakoram has had an overall slight positive glacier mass balance since the end of 20th century, which is anomalous given that most other regions in High Mountain Asia have had negative changes. A large number of advancing, retreating, and surging glaciers are heterogeneously mixed in the Karakoram increasing the difficulties and inaccuracies to identify glacier surges. We found two adjacent glaciers in the eastern Karakoram behaving differently from 1995 to 2019: one was surging and the other was advancing. In order to figure out the differences existing between them and the potential controls on surges in this region, we collected satellite images from Landsat series, ASTER, and Google Earth, along with two sets of digital elevation model. Utilizing visual interpretation, feature tracking of optical images, and differencing between digital elevation models, three major differences were observed: (1) the evolution profiles of the terminus positions occupied different change patterns; (2) the surging glacier experienced a dramatic fluctuation in the surface velocities during and after the event, while the advancing glacier flowed in a stable mode; and (3) surface elevation of the surging glacier decreased in the reservoir and increased in the receiving zone. However, the advancing glacier only had an obvious elevation increase over its terminus part. These differences can be regarded as standards for surge identification in mountain ranges. After combining the differences with regional meteorological conditions, we suggested that changes of thermal and hydrological conditions could play a role in the surge occurrence, in addition, geomorphological characteristics and increasing warming climate might also be part of it. This research strongly contributes to the literatures of glacial motion and glacier mass change in the eastern Karakoram through remote sensing.
The First Pi2 Pulsation Observed by China Seismo-Electromagnetic Satellite
Authors: Ghamry Essam , Marchetti Dedalo , Yoshikawa Akimasa , Uozumi Teiji , De Santis Angelo , Perrone Loredana , Shen Xuhui , Fathy Adel
Published: July 2020

On 2 February 2018, the China Seismo-Electromagnetic Satellite (CSES) ZhangHeng 01 (ZH-01) was successfully launched, carrying on board, in addition to a suite of plasma and particle physics instruments, a high precision magnetometer package (HPM), able to observe the ultra-low frequency (ULF) waves. In this paper, a night time Pi2 pulsation observed by CSES is reported for the first time. This Pi2 event occurred on 3 September 2018, and began at 14:30 UT (02:37 magnetic local time), when the satellite was in the southern hemisphere between −49 and −13 magnetic latitude (MLAT). Kakioka (KAK) ground station in Japan detected the same Pi2 between 14:30–14:42 UT (23:30–23:42 local time). The Pi2 oscillations in the compressional, toroidal, and poloidal components at the CSES satellite and the H-component at the KAK station are investigated by estimating coherence, amplitude, and cross-phase. We noticed a high degree of similarity between the Pi2 event in the horizontal component at KAK and the ionospheric fluctuations in the compressional component at CSES. This high correlation indicated the magnetospheric source of the Pi2 event. In addition, Pi2 is exhibited clearly in the δBy component at CSES, which is highly correlated with the ground H component, so the Pi2 event could be explained by the Substorm Current Wedge (SCW). This interpretation is further confirmed by checking the compressional component of Van Allen Probe (VAP) B satellite inside the plasmasphere, which, for the first time, gives observational support for an earlier model. This ULF wave observation shows the consistency and reliability of the high precision magnetometer (HPM) equipped by two fluxgate magnetometers (FGM1 and FGM2) onboard CSES.
BIM-Based Registration and Localization of 3D Point Clouds of Indoor Scenes Using Geometric Features for Augmented Reality
Authors: Mahmood Bilawal , Han SangUk , Lee Dong-Eun
Published: July 2020

Augmented reality can improve construction and facility management by visualizing an as-planned model on its corresponding surface for fast, easy, and correct information retrieval. This requires the localization registration of an as-built model in an as-planned model. However, the localization and registration of indoor environments fail, owing to self-similarity in an indoor environment, relatively large as-planned models, and the presence of additional unplanned objects. Therefore, this paper proposes a computer vision-based method to (1) homogenize indoor as-planned and as-built models, (2) reduce the search space of model matching, and (3) localize the structure (e.g., room) for registration of the scanned area in its as-planned model. This method extracts a representative horizontal cross section from the as-built and as-planned point clouds to make these models similar, restricts unnecessary transformation to reduce the search space, and corresponds the line features for the estimation of the registration transformation matrix. The performance of this method, in terms of registration accuracy, is evaluated on as-built point clouds of rooms and a hallway on a building floor. A rotational error of 0.005 rad and a translational error of 0.088 m are observed in the experiments. Hence, the geometric feature described on a representative cross section with transformation restrictions can be a computationally cost-effective solution for indoor localization and registration.
Analysis of UAS Flight Altitude and Ground Control Point Parameters on DEM Accuracy along a Complex, Developed Coastline
Authors: Zimmerman Taylor , Jansen Karine , Miller Jon
Published: July 2020

Measuring beach topography accurately and with high spatial resolution is an important aspect of coastal management and is crucial for understanding changes in beach morphology, especially along complex, three-dimensional shorelines. Traditional methods of beach surveying even at high resolution are insufficient to measure the complex, dynamic behavior along these coasts. This study investigates the optimization of Unmanned Aerial Systems Structure from Motion (UAS-SfM) data acquisition methodology with regard to flight altitude and the configuration and amount of ground control points (GCPs). A sensitivity analysis was performed to determine the UAS and GCP characteristics that produce the most accurate digital elevation model (DEM). First, an evaluation of the UAS-SfM technique was performed and proved advantageous over traditional surveying techniques with regard to efficiency, automation, ease of use, and repeatability. The results of the sensitivity analysis showed the highest (116 m) flight altitude evaluated was the most accurate and required the least amount of survey and processing time. The optimal configuration of GCPs was determined to be (1) in the corners of the study site, (2) at high and low elevations within the study site, and (3) with sufficient cross-shore and alongshore coverage. Finally, it was found that 15 GCPs produced the best results, but that as few as 11 GCPs could be used without any significant loss in accuracy. It was also observed that fewer (≈7–9) well-placed GCPs in the optimal configuration produced the same magnitude of error as using more (15) poorly placed GCPs. Based on these results, a set of recommendations for conducting UAS-SfM surveys along complex, three-dimensional, developed coastlines is presented.
Cloud Observation and Cloud Cover Calculation at Nighttime Using the Automatic Cloud Observation System (ACOS) Package
Authors: Kim Bu-Yo , Cha Joo Wan
Published: July 2020

An Automatic Cloud Observation System (ACOS) and cloud cover calculation algorithm were developed to calculate the cloud cover at night, and the calculation results were compared with the cloud cover data of a manned observatory (Daejeon Regional Office of Meteorology, DROM) that records human observations. Annual and seasonal analyses were conducted using the 1900–0600 local standard time (LST) hourly data from January to December 2019. Prior to calculating the cloud cover of ACOS, pre-processing was performed by removing surrounding obstacles and correcting the distortion caused by the fish-eye lens. In addition, the red–blue ratio (RBR) threshold was determined, according to the image characteristics (RBR and luminance) using the red, green, and blue (RGB) brightness value of the area in which the solar zenith angle (SZA) was less than 80°, to calculate the cloud cover. The calculated cloud cover exhibited a bias of −0.28 tenths, root mean square error (RMSE) of 1.78 tenths, and a correlation coefficient of 0.91 for DROM across all cases. The frequency of the cases that exhibited differences less than 1 tenth between the observed and calculated cloud cover was 46.82%, while the frequency of cases that exhibited differences less than 2 tenths was 87.79%.
Semi-Automatization of Support Vector Machines to Map Lithium (Li) Bearing Pegmatites
Authors: Cardoso-Fernandes Joana , Teodoro Ana C. , Lima Alexandre , Roda-Robles Encarnación
Published: July 2020

Machine learning (ML) algorithms have shown great performance in geological remote sensing applications. The study area of this work was the Fregeneda–Almendra region (Spain–Portugal) where the support vector machine (SVM) was employed. Lithium (Li)-pegmatite exploration using satellite data presents some challenges since pegmatites are, by nature, small, narrow bodies. Consequently, the following objectives were defined: (i) train several SVM’s on Sentinel-2 images with different parameters to find the optimal model; (ii) assess the impact of imbalanced data; (iii) develop a successful methodological approach to delineate target areas for Li-exploration. Parameter optimization and model evaluation was accomplished by a two-staged grid-search with cross-validation. Several new methodological advances were proposed, including a region of interest (ROI)-based splitting strategy to create the training and test subsets, a semi-automatization of the classification process, and the application of a more innovative and adequate metric score to choose the best model. The proposed methodology obtained good results, identifying known Li-pegmatite occurrences as well as other target areas for Li-exploration. Also, the results showed that the class imbalance had a negative impact on the SVM performance since known Li-pegmatite occurrences were not identified. The potentials and limitations of the methodology proposed are highlighted and its applicability to other case studies is discussed.