bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurotización: concepto clave en reparación nerviosa
Authors: Barreto Niño Ana Maria , Nieto Ramírez Luis Eduardo
Published: July 2021

La neurotización es el fenómeno por el cual un brote axonal alcanza la estructura de un nervio periférico lesionado, coloniza un tejido y produce en este, la función que tiene determinado el cuerpo celular al cual pertenece esta prolongación axonal.

Los tipos de neurotización dependen del tejido a inervar, teóricamente cualquier tejido podría ser neurotizado, siendo utilizados la neurotización nerviosa, ya sea del mismo nervio o con un nervio diferente. Esta revisión tiene el objetivo de explicar los diferentes tipos de neurotización.
Effects of cricothyroid and thyroarytenoid interaction on voice control: Muscle activity, vocal fold biomechanics, flow, and acoustics
Authors: Movahhedi Mohammadreza , Geng Biao , Xue Qian , Zheng Xudong
Published: July 2021

An MRI-based three-dimensional computer model of a canine larynx was used to investigate the effect of cricothyroid (CT) and thyroarytenoid (TA) muscle activity on vocal fold pre-phonatory posturing and glottic dynamics during voice production. Static vocal fold posturing in the full activation space of CT and TA muscles was first simulated using a laryngeal muscle mechanics model; dynamic flow-structure-acoustics interaction (FSAI) simulations were then performed to predict glottal flow and voice acoustics. The results revealed that TA activation decreased the length and increased the bulging, height, and contact area of the vocal fold. CT activation increased the length and contact area and decreased the height of the vocal fold. Both CT and TA activations increased the vocal fold stress, stiffness, and closure quotient; and only slightly affected the flow rate and voice intensity. Furthermore, CT and TA showed a complex control mechanism on the fundamental frequency pattern, which highly correlated with a combination of the stress, stiffness, and stretch of the vocal fold.
A live single-cell reporter assay links intratumor heterogeneity to metastatic proclivity in Ewing sarcoma
Authors: Keskin Tugba , Rucci Beatrice , Cornaz-Buros Sandrine , Martin Patricia , Fusco Carlo , Broye Liliane , Cisarova Katarina , Perez Elizabeth M. , Letovanec Igor , La Rosa Stefano , Cherix Stephane , Diezi Manuel , Renella Raffaele , Provero Paolo , Suvà Mario L. , Stamenkovic Ivan , Riggi Nicolò
Published: July 2021

A miRNA-based in vivo reporter deciphers cell heterogeneity in Ewing sarcoma.
A methylotrophic origin of methanogenesis and early divergence of anaerobic multicarbon alkane metabolism
Authors: Wang Yinzhao , Wegener Gunter , Williams Tom A. , Xie Ruize , Hou Jialin , Tian Chen , Zhang Yu , Wang Fengping , Xiao Xiang
Published: July 2021

Phylogenomic analyses reveal the origin and evolution of anaerobic alkane metabolism in the domain Archaea.
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy
Authors: Siwicki Marie , Gort-Freitas Nicolas A. , Messemaker Marius , Bill Ruben , Gungabeesoon Jeremy , Engblom Camilla , Zilionis Rapolas , Garris Christopher , Gerhard Genevieve M. , Kohl Anna , Lin Yunkang , Zou Angela E. , Cianciaruso Chiara , Bolli Evangelia , Pfirschke Christina , Lin Yi-Jang , Piot Cecile , Mindur John E. , Talele Nilesh , Kohler Rainer H. , Iwamoto Yoshiko , Mino-Kenudson Mari , Pai Sara I. , deVito Claudio , Koessler Thibaud , Merkler Doron , Coukos Alexander , Wicky Alexandre , Fraga Montserrat , Sempoux Christine , Jain Rakesh K. , Dietrich Pierre-Yves , Michielin Olivier , Weissleder Ralph , Klein Allon M. , Pittet Mikael J.
Published: July 2021

Resident macrophages and recruited neutrophils cause toxicities in tumor-free tissues after immunotherapy.
Evaluation of a Rapid Antigen Test To Detect SARS-CoV-2 Infection and Identify Potentially Infectious Individuals
Authors: Korenkov Michael , Poopalasingam Nareshkumar , Madler Matthias , Vanshylla Kanika , Eggeling Ralf , Wirtz Maike , Fish Irina , Dewald Felix , Gieselmann Lutz , Lehmann Clara , Fätkenheuer Gerd , Gruell Henning , Pfeifer Nico , Heger Eva , Klein Florian
Published: July 2021

The identification and isolation of highly infectious SARS-CoV-2-infected individuals is an important public health strategy. Rapid antigen detection tests (RADT) are promising candidates for large-scale screenings due to timely results and feasibility for on-site testing.
Quaternary chronology and rock uplift recorded by marine terraces, Gaviota coast, Santa Barbara County, California, USA
Authors: Morel Daniel L. , Morell Kristin D. , Keller Edward A. , Rittenour Tammy M.
Published: July 2021

The Transverse Ranges of southern California are a region of active transpression on the western margin of North America that hosts some of the world's highest uplift rates at the Ventura anticline. Yet, the manner in which rock uplift rates change along strike from Ventura to the westernmost Transverse Ranges and the structures that may be responsible for this uplift remain unclear. Here, we quantified rock uplift rates within the westernmost 60 km of the Transverse Ranges by obtaining new age constraints from raised beach and shoreface deposits from marine terraces along the Gaviota coast. Twelve radiocarbon (seven sites) and eight luminescence (six sites) ages, ranging from ca. 50 to 40 k.y. B.P. and ca. 56 to 43 ka, respectively, consistently suggest that the first emergent terrace dates to marine isotope stage (MIS) 3, rather than MIS 5a as previously reported for the western Gaviota coast. These younger ages yield rock uplift rates between 0.8 ± 0.3 and 1.8 ± 0.4 m/k.y., i.e., over five times higher than previous estimates for this region. The spatial distribution of rock uplift rates and the abrupt along-strike changes in marine terrace elevations favor a regional tectonic model with a step-wise change in rock uplift across the south branch of the Santa Ynez fault. The south branch of the Santa Ynez fault appears to separate two regional tectonic blocks, characterized by rock uplift rates of ∼1.3–1.6 m/k.y. to the east and slightly lower rates to the west (∼0.8–1.4 m/k.y.). Our observations suggest that coastal rock uplift is primarily accommodated by deeply rooted far-field structures such as the offshore Pitas Point–North Channel fault system and the Santa Ynez fault, and that smaller through-going structures impart second-order controls and locally accommodate short-wavelength (<10-km-long strike length) deformation. These results imply that although the rates of rock uplift decline westward along strike, the westernmost portion of the western Transverse Ranges nonetheless accommodates relatively high (>1 m/k.y.) rock uplift rates at a significant distance (>50 km) from the rapidly uplifting (6–7 m/k.y.) Ventura anticline, and >100 km from the prominent restraining bend (“Big Bend”) in the San Andreas fault. The new constraints on the geometry of Quaternary-active structures and regional rates of fault-related deformation have implications for regional earthquake source models and seismic hazard assessment in the highly populated southern California coast region.
Evaluating the role of topographic inversion in the formation of the Stanislaus Table Mountains in the Sierra Nevada (California, USA)
Authors: Gabet Emmanuel
Published: July 2021

The Table Mountains, a flat-topped series of ridges capped by a 10.4 Ma latite flow in the Stanislaus River watershed, are considered to be evidence for late Cenozoic uplift-driven landscape rejuvenation in the northern Sierra Nevada range (California, USA). The commonly accepted theory for the formation of these mesas posits that the latite flowed and cooled within a bedrock paleovalley and, since then, the surrounding landscape has eroded away, leaving behind the volcanic deposit as a ridge. Although this theory is accepted by many, it has not been thoroughly tested. In this study, I examine a series of geological cross-sections extracted along the length of the latite deposit to determine whether the evidence supports the existence of bedrock valley walls on both sides of the 10.4 Ma flow. I find that the presence of older Cenozoic deposits adjacent to the latite flow precludes the possibility that the flow would have been constrained within a bedrock valley. Moreover, the cross-section from an 1865 report that has been offered as evidence of topographic inversion (and subsequently reproduced in numerous publications) does not accurately represent the topography at that site. I conclude that there is no evidence that the bedrock topography has been inverted and that instead, the latite flowed within a channel cut into underlying Cenozoic deposits, which have since mostly eroded away. This study, therefore, refutes the hypothesis that the Stanislaus River watershed was rejuvenated in the late Cenozoic and challenges the claim for recent significant uplift of the region.
Sr isotopes in the Tortonian-Messinian Lake Bira and Gesher marshes, Northern Valleys of Israel: Implications for hydroclimate changes in East Mediterranean–Levant margins
Authors: Rozenbaum A.G. , Stein M. , Zilberman E. , Gelband D. Shaked , Starinsky A. , Sandler A.
Published: July 2021

87Sr/86Sr isotope and Sr/Ca ratios in lacustrine carbonates were used to reconstruct the hydroclimate conditions in the watershed of Lake Bira that filled during the Tortonian-Messinian the tectonic depressions of the Northern Valleys of Israel in the East Mediterranean-Levant region. 87Sr/86Sr ratios of the Tortonian (ca. 10–8 Ma) carbonates of ∼0.7075 and the great expansion of the lake indicate wet conditions and enhanced supply of freshwater from the regional Mesozoic aquifers. Upon the transition to the Messinian period (ca. 7–6 Ma), the 87Sr/86Sr ratios in the carbonates rose to ∼0.7080–0.7085, reflecting the contribution of Sr from Sahara Desert dusts that came to comprise the regional surface cover. This contribution is also reflected in the silicate fraction of the lacustrine formations that show “granitic-crustal” 87Sr/86Sr ratios of ∼0.711. During the Messinian salinity crisis (5.9–5.6 Ma), the region became arid and Lake Bira possibly dried. Later, during the Lago Mare stage (ca. 5.5–5.3 Ma), the rainfall increased and paludal waterbodies scattered the area of the larger Lake Bira.
Metamorphism and geochronology of high-pressure mafic granulites (retrograded eclogites?) in East Cathaysia terrane of South China: Implications for Mesozoic tectonic evolution
Authors: Xia Yanfei , Yin Changqing , Lin Shoufa , Zhang Jian , Qian Jiahui , Wu Shangjing , Liu Jingna
Published: July 2021

High-pressure mafic granulites (retrograded eclogites?) were discovered as minor lenses enclosed in garnet-kyanite-cordierite gneiss from the Badu Complex of the East Cathaysia terrane in South China. These rocks consist mainly of garnet, clinopyroxene, hornblende, quartz, and rutile/ilmenite with or without omphacite pseudomorphs that are indicated by clinopyroxene + sodic plagioclase symplectic intergrowths. Mineral textures and reaction relationships suggest three metamorphic stages: (1) an eclogite-facies stage (M1) characterized by the mineral assemblage of garnet + clinopyroxene (omphacite) + hornblende + rutile + quartz; (2) a high-pressure granulite-facies (M2) stage mainly represented by garnet + clinopyroxene + plagioclase + hornblende + rutile + quartz in the matrix; and (3) an amphibolite retrograde stage (M3) defined by hornblende + plagioclase + ilmenite + quartz symplectites surrounding garnet porphyroblasts. Conventional geothermometers and geobarometers in combination with phase equilibria modeling constrain metamorphic P–T conditions of 15.8–18.2 kbar/625–690 °C (M1), 11.8–14.5 kbar/788–806 °C (M2), and 5.4–6.4 kbar/613–668 °C (M3), respectively. Two-staged decompression processes are defined after the peak pressure, which suggests a two-staged exhumation of these deeply buried rocks. Secondary ion mass spectrometry (SIMS) zircon U-Pb dating and trace element analysis show that the high-pressure metamorphism occurred at 240–244 Ma. Complete early Mesozoic orogenic processes characterized by initial subduction and/or crustal thickening and subsequent exhumation followed by rapid uplift are reconstructed for this part of the East Cathaysia terrane, South China.
Early Pleistocene–to–present paleoclimate archive for the American Southwest from Stoneman Lake, Arizona, USA
Authors: Staley Spencer E. , Fawcett Peter J. , Anderson R. Scott , Jiménez-Moreno Gonzalo
Published: July 2021

Long, continuous records of terrestrial paleoclimate offer insights into natural climate variability and provide context for geomorphological studies, climate model reconstructions, and predictions of future climate change. STL14 is an 80 m lacustrine sediment core that archives paleoenvironmental changes at Stoneman Lake, Coconino County, Arizona, from the early Pleistocene (ca. 1.3 Ma) to present. Full-core sedimentology was analyzed using smear slides and core face observations. Lithofacies strongly correlate with wet bulk density and bulk magnetic susceptibility (MS), and these data resemble a sawtooth pattern characteristic of glacial-interglacial climate cycles. A linkage between deep to shallow lake depth transitions and glacial terminations is supported by an age model that incorporates accelerator mass spectrometry radiocarbon dates and tephrochronology of ashes from the Lava Creek B and multiple Long Valley, California, volcanic eruptions. We correlated middle and late Pleistocene glacial maxima to deep lake deposits defined by well-preserved bedding, increased biosilica, boreal pollen taxa (i.e., Picea), and lower density and MS. Interglacial periods are associated with shallow-water deposits characterized by banded-to-massive siliciclastic material, some authigenic calcite, the alga Phacotus, and higher density and MS. Prior to the marine isotope stage (MIS) 24–22 interval, smaller-amplitude changes in the lake environment suggest milder glacial conditions compared to those of the middle and late Pleistocene. Thus, abrupt intensification of glacial conditions may have occurred ca. 900 ka in the American Southwest, mirroring a global characteristic of the mid-Pleistocene transition. The STL14 record suggests that lake environments throughout the history of this small (3.5 km2), internally drained, basaltic catchment are sensitive to the regional hydrologic balance, which, at orbital time scales, is largely influenced by the northern cryosphere and associated changes in atmospheric circulation. The predominance of quartz in sediment throughout the record indicates significant eolian inputs. Few paleoclimate records from this region extend beyond the last glacial cycle, let alone the middle Pleistocene, making STL14 a valuable resource for studying environmental responses to a range of natural climate states and transitions throughout much of the Quaternary.
Cost-effectiveness of single-layer versus double-layer uterine closure during caesarean section on postmenstrual spotting: economic evaluation alongside a randomised controlled trial
Authors: Stegwee Sanne I. , Ben Ângela J. , El Alili Mohamed , van der Voet Lucet F. , de Groot Christianne J.M. , Bosmans Judith E. , Huirne Judith A.F.
Published: July 2021

Objective

To evaluate the cost-effectiveness of double-layer compared with single-layer uterine closure after a first caesarean section (CS) from a societal and healthcare perspective.

Design

Economic evaluation alongside a multicentre, double-blind, randomised controlled trial.

Setting

32 hospitals in the Netherlands, 2016–2018.

Participants

2292 women ≥18 years undergoing a first CS were randomly assigned (1:1). Exclusion criteria were: inability for counselling, previous uterine surgery, known menstrual disorder, placenta increta or percreta, pregnant with three or more fetuses. 1144 women were assigned to single-layer and 1148 to double-layer closure. We included 1620 women with a menstrual cycle in the main analysis.

Interventions

Single-layer unlocked uterine closure and double-layer unlocked uterine closure with the second layer imbricating the first.

Main outcome measures

Spotting days, quality-adjusted life-years (QALYs), and societal costs at 9 months of follow-up. Missing data were imputed using multiple imputation.

Results

No significant differences were found between single-layer versus double-layer closure in mean spotting days (1.44 and 1.39 days; mean difference (md) −0.056, 95% CI −0.374 to 0.263), QALYs (0.663 and 0.658; md −0.005, 95% CI −0.015 to 0.005), total healthcare costs (€744 and €727; md €−17, 95% CI −273 to 143), and total societal costs (€5689 and €5927; md €238, 95% CI −624 to 1108). The probability of the intervention being cost-effective at willingness-to-pay of €0, €10 000 and €20 000/QALY gained was 0.30, 0.27 and 0.25, respectively, (societal perspective), and 0.55, 0.41 and 0.32, respectively, (healthcare perspective).

Conclusion

Double-layer uterine closure is not cost-effective compared with single-layer uterine closure from both perspectives. If this is confirmed by our long-term reproductive follow-up, we suggest to adjust uterine closure technique guidelines.

Trial registration number

NTR5480/NL5380.
Is the physical activity environment surrounding primary schools associated with students’ weight status, physical activity or active transport, in regional areas of Victoria, Australia? A cross-sectional study
Authors: Jacobs Jane , Crooks Nic , Allender Steven , Strugnell Claudia , Backholer Kathryn , Nichols Melanie
Published: July 2021

Objectives

To explore whether the physical activity (PA) environment (walkability, greenspace and recreational facilities) surrounding regional primary schools is associated with children’s PA levels, active transport and weight status. Limited research on this topic has been conducted outside of major cities.

Design

Cross-sectional ecological study using baseline data from two large-scale obesity prevention interventions.

Setting

Eighty (n=80) primary schools across two regional areas in Victoria, Australia.

Participants

Students aged 8–13 years (n=2144) attending participating primary schools.

Outcome measures

Measured weight status (body mass index z-score, proportion overweight/obese) and self-reported PA behaviours (meeting PA recommendations and active travel behaviour).

Results

When adjusted for student and school demographics, students had significantly increased odds of using active transport to or from school when the school neighbourhood was more walkable (OR 1.21 (95% CI 1.09 to 1.35), had a greater number of greenspaces (OR 1.35 (95% CI 1.20 to 1.53)) and a greater number of recreational facilities (OR 1.18 (95% CI 1.07 to 1.31)). A higher cumulative PA environment score was also associated with a higher proportion of children using active transport (OR 1.33 (95% CI 1.28 to 1.51)). There were no significant associations between the PA environment measures and either weight status or meeting the PA recommendations in adjusted models.

Conclusions

This study is the first of its kind exploring school neighbourhood environments and child weight status and PA in regional areas of Australia. It highlights the potential of the environment surrounding primary schools in contributing to students’ active travel to and from school. Further research with the use of objective PA measurement is warranted in regional areas that have been under-researched.

Trial registration number

Australian New Zealand Clinical Trials Registry (ANZCTR.org.au) identifier 12616000980437; Results.
Non-medical devices for chronic breathlessness: use, barriers and facilitators for patients, carers and clinicians - a scoping review
Authors: Prihartadi Aliya Syahreni , Impelliziere Licastro Giovanna , Pearson Mark , Johnson Miriam J , Luckett Tim , Swan Flavia
Published: July 2021

Background

Non-medical devices such as the handheld fan (fan), mobility aids (wheeled walkers with seats) and inspiratory muscle training (IMT) devices offer benefits for patient management of chronic breathlessness. We examined the published evidence regarding patient, carer and clinician use of the fan, mobility aids and IMT devices for chronic breathlessness management, and the potential barriers and facilitators to day-to-day use in a range of settings.

Methods

MEDLINE, Embase, Scopus, EBSCO and the Cochrane Database of Systematic Reviews were searched. Papers were imported into EndNote and Rayyan for review against a priori eligibility criteria. Outcome data relevant to use were extracted and categorised as potential barriers and facilitators, and a narrative synthesis exploring reasons for similarities and differences conducted.

Results

Seven studies met the inclusion criteria (n=5 fan, n=2 mobility aids and n=0 IMT devices). All of the studies presented patient use of non-medical devices only. Patients found the fan easy to use at home. Mobility aids were used mainly for outdoor activities. Outdoor use for both devices were associated with embarrassment. Key barriers included: appearance; credibility; self-stigma; technical specifications. Common facilitators were ease of use, clinical benefit and feeling safe with the device.

Conclusion

The efforts of patients, carers and clinicians to adopt and use non-medical devices for the management of chronic breathlessness is impeded by lack of implementation research. Future research should improve knowledge of the barriers and facilitators to use. This would enhance understanding of how decision-making in patient–carer–clinician triads impacts on non-medical devices use for breathlessness management.
Determinants of response to daratumumab in Epstein-Barr virus-positive natural killer and T-cell lymphoma
Authors: Mustafa Nurulhuda , Nee Adina Huey Fang , Chooi Jing Yuan , Toh Sabrina Hui Min , Chung Tae-Hoon , Selvarajan Viknesvaran , Fan Shuangyi , Ng Siok Bian , Poon Michelle , Chan Esther , Lee Joanne , Chee Yen Lin , Jeyasekharan Anand D , Zhou Longen , Yang Jennifer , Chng Wee Joo
Published: July 2021

Background

The potential therapeutic efficacy of daratumumab in natural killer T-cell lymphoma (NKTL) was highlighted when its off-label usage produced sustained remission in a patient with highly refractory disease. This is corroborated recently by a phase II clinical trial which established that daratumumab monotherapy is well tolerated and displayed encouraging response in relapsed/refractory NKTL patients. However, little is known regarding the molecular factors central to the induction and regulation of the daratumumab-mediated antitumor response in NKTL.

Methods

CD38 expression was studied via immunohistochemistry, multiplex immunofluorescence and correlated with clinical characteristics of the patient. The therapeutic efficacy of daratumumab was studied in vitro via CellTiter-Glo (CTG) assay, complement-dependent cytotoxicity (CDC), antibody-dependent cell cytotoxicity (ADCC), and in vivo, via a patient-derived xenograft mouse model of NKTL, both as a single agent and in combination with L-asparaginase. Signaling mechanisms were characterized via pharmacologic treatment, RNA silencing, flow cytometry and corroborated with public transcriptomic data of NKTL.

Results

Epstein-Barr virus-positive NKTL patients significantly express CD38 with half exhibiting high expression. Daratumumab effectively triggers Fc-mediated ADCC and CDC in a CD38-dependent manner. Importantly, daratumumab monotherapy and combination therapy with L-asparaginase significantly suppresses tumor progression in vivo. Ablation of complement inhibitory proteins (CIP) demonstrate that CD55 and CD59, not CD46, are critical for the induction of CDC. Notably, CD55 and CD59 expression were significantly elevated in the late stages of NKTL. Increasing the CD38:CIP ratio through sequential CIP knockdown, followed by CD38 upregulation via All-Trans Retinoic Acid treatment, potently augments complement-mediated lysis in cells previously resistant to daratumumab. The CD38:CIP ratio consistently demonstrates a statistically superior correlation to antitumor efficacy of daratumumab than CD38 or CIP expression alone.

Conclusion

This study characterizes CD38 as an effective target for a subset of NKTL patients and the utilization of the CD38:CIP ratio as a more robust identifier for patient stratification and personalisation of treatment. Furthermore, elucidation of factors which sensitize the complement-mediated response provides an alternative approach toward optimizing therapeutic efficacy of daratumumab where CDC remains a known limiting factor. Altogether, these results propose a strategic rationale for further evaluation of single or combined daratumumab treatment in the clinic for NKTL.
Early rise in brain damage markers and high ICOS expression in CD4+ and CD8+ T cells during checkpoint inhibitor-induced encephalomyelitis
Authors: Bjursten Sara , Pandita Ankur , Zhao Zhiyuan , Fröjd Charlotta , Ny Lars , Jensen Christer , Ullerstam Tobias , Jespersen Henrik , Borén Jan , Levin Malin , Zetterberg Henrik , Rudin Anna , Levin Max
Published: July 2021

We report a case of rapid eradication of melanoma brain metastases and simultaneous near-fatal encephalomyelitis following double immune checkpoint blockade. Brain damage marker S-100B and C reactive protein increased before symptoms or signs of encephalomyelitis and peaked when the patient fell into a coma. At that point, additional brain damage markers and peripheral T cell phenotype was analyzed. The analyses were repeated four times during the patient’s recovery. Axonal damage marker neurofilament light polypeptide (NFL) and astrocytic damage marker glial fibrillar acidic protein (GFAP) were very high in blood and cerebrospinal fluid and gradually normalized after immunosuppression and intensive care. The costimulatory receptor inducible T cell costimulatory receptor (ICOS) was expressed on a high proportion of CD4+ and CD8+T cells as encephalomyelitis symptoms peaked and then gradually decreased in parallel with clinical improvement. Both single and double immune checkpoint inhibitor-treated melanoma patients with other serious immune-related adverse events (irAE) (n=9) also expressed ICOS on a significantly higher proportion of CD4+ and CD8+T cells compared with controls without irAE (n=12). In conclusion, our results suggest a potential role for ICOS on CD4+ and CD8+T cells in mediating encephalomyelitis and other serious irAE. In addition, brain damage markers in blood could facilitate early diagnosis of encephalitis.
Feasibility of a daily noise monitoring intervention for prevention of noise-induced hearing loss
Authors: Rabinowitz Peter , Galusha Deron , Cantley Linda F , Dixon-Ernst Christine , Neitzel Richard
Published: July 2021

Background

Despite the existence of hearing conservation programmes complying with regulatory standards, noise-induced hearing loss (NIHL) remains one of the most prevalent occupational diseases. Compulsory daily monitoring of noise exposure has been associated with decreased NIHL risk. We report on the experience of a voluntary daily noise monitoring intervention among noise-exposed workers.

Methods

Workers at three locations of a metals manufacturing company voluntarily used an in-ear noise monitoring device that could record and download, on a daily basis, the noise exposure inside of their hearing protection. We compared the hearing loss rates (in decibels hearing level/year) in these volunteers to controls from the same company matched for job title, age, gender, race, plant location, and baseline hearing level.

Results

Over the follow-up period, 110 volunteers for whom controls could be identified monitored daily noise exposures an average of 150 times per year. Noise exposures inside of hearing protection were lower than ambient noise levels estimated from company records. While there was no significant difference in hearing loss rates between volunteers and controls, volunteers downloading exposures 150 times per year or had less hearing loss than those who downloaded less frequently.

Conclusion

These results indicate that voluntary daily noise exposure monitoring by workers is feasible and that greater frequency of downloading is associated with less hearing loss. If further development of noise monitoring technology can improve usability and address barriers to daily use, regular self-monitoring of noise exposure could improve the effectiveness of hearing conservation programmes.

Trial registration number

NCT01714375.
Is preoperative genicular radiofrequency ablation effective for reducing pain following total knee arthroplasty? A pilot randomized clinical trial
Authors: Mishra Puneet , Edwards David , Huntoon Marc , Sobey Christopher , Polkowski Gregory , Corey John , Mishra Kelly Louise , Shinar Andrew , Engstrom Stephen , Palmer Cassandra , Bruehl Stephen
Published: July 2021

Background and objective

Although total knee arthroplasty (TKA) is an effective treatment for severe knee osteoarthritis (OA), a subset of patients experience significant postoperative pain and dissatisfaction. Several clinical trials support the analgesic benefits of genicular nerve radiofrequency ablation (GN-RFA) for non-operative knee OA, but only one prior trial has examined the effects of this intervention given preoperatively on postoperative outcomes following TKA, showing no analgesic benefit of cooled GN-RFA. The current study evaluated whether conventional thermal GN-RFA performed preoperatively resulted in significant improvements in pain and function following TKA.

Methods

This was a single-center, prospective, randomized, sham-controlled, double-blinded pilot trial in which patients received either conventional GN-RFA (n=30) or sham (n=30) between 2 and 4 weeks prior to their TKA. Baseline measures were obtained preprocedurally on the day of intervention, with follow-up outcomes obtained preoperatively on the day of surgery, and at 2 and 6 weeks postoperatively.

Results

Patients receiving GN-RFA showed no significant improvements relative to sham controls in the primary outcome, pain intensity at rest at 6-week follow-up. Secondary outcomes, including pain with ambulation and physical function, also showed no significant differences between groups at any follow-up assessment.

Conclusions

Conventional GN-RFA of the superior lateral, superior medial, and inferior medial genicular nerves when performed prior to TKA did not provide clinically significant pain relief or improvement in functional status at 2 or 6 weeks postoperatively.

Trial registration number

NCT02947321
.
Jet mass distribution in Higgs/vector boson + jet events at hadron colliders with $${{\varvec{k}}}_{{\varvec{t}}}$$ clustering
Authors: Ziani Naïma , Khelifa-Kerfa Kamel , Delenda Yazid
Published: July 2021

We address the issues of clustering and non-global logarithms for jet shapes in the process of production of a Higgs/vector boson associated with a single hard jet at hadron colliders. We perform an analytical fixed-order calculation up to second order in the coupling as well as an all-orders estimation for the specific invariant mass distribution of the highest-$$p_t$$

p
t

jet, for various jet algorithms. Our results are derived in the eikonal (soft) limit and are valid up to next-to-leading logarithmic accuracy. We perform a matching of the resummed distribution to next-to-leading order results from and compare our findings with the outputs of the Monte Carlo event generators and . After accounting for non-perturbative effects we compare our results with available experimental data from the CMS collaboration for the Z + jet production. We find good agreement over a wide range of the observable.
Discrete phase space and continuous time relativistic quantum mechanics I: Planck oscillators and closed string-like circular orbits
Authors: Das Anadijiban , Chatterjee Rupak
Published: July 2021

The discrete phase space continuous time representation of relativistic quantum mechanics involving a characteristic length [Formula: see text] is investigated. Fundamental physical constants such as [Formula: see text], [Formula: see text], and [Formula: see text] are retained for most sections of the paper. The energy eigenvalue problem for the Planck oscillator is solved exactly in this framework. Discrete concircular orbits of constant energy are shown to be circles [Formula: see text] of radii [Formula: see text] within the discrete [Formula: see text]-dimensional phase plane. Moreover, the time evolution of these orbits sweep out world-sheet like geometrical entities [Formula: see text] and therefore appear as closed string-like geometrical configurations. The physical interpretation for these discrete orbits in phase space as degenerate, string-like phase cells is shown in a mathematically rigorous way. The existence of these closed concircular orbits in the arena of discrete phase space quantum mechanics, known for the non-singular nature of lower order expansion [Formula: see text] matrix terms, was known to exist but has not been fully explored until now. Finally, the discrete partial difference-differential Klein–Gordon equation is shown to be invariant under the continuous inhomogeneous orthogonal group [Formula: see text].
Ambipolar decay of magnetic field in magnetars and the observed magnetar activities
Authors: Bhalla Badal , Sinha Monika
Published: July 2021

Magnetars are comparatively young neutron stars with ultra-strong surface magnetic field in the range [Formula: see text]. The old neutron stars have surface magnetic field somewhat less [Formula: see text][Formula: see text][Formula: see text] which clearly indicates the decay of field with time. One possible way of magnetic field decay is by ambipolar diffusion. We describe the general procedure to solve for the ambipolar velocity inside the star core without any approximation. With a realistic model of neutron star, we determine the ambipolar velocity configuration inside the neutron star core and hence find the ambipolar decay rate, associated timescales and the magnetic energy dissipated which is consistent with the magnetar observations.
Estimation of fission yield and cross-section for thorium-based molten salt reactor and accelerator driven system
Authors: Artun Ozan
Published: July 2021

Thorium is the primary candidate fuel in Thorium-based Molten Salt Reactor (TMSR) and Accelerator Driven System (ADS). However, to utilize Thorium in the reactor and accelerator systems, nuclear data in the literature are not sufficient for neutron-induced fission reaction process. Therefore, we estimated neutron fission cross-section [Formula: see text] (mb), independent [Formula: see text] and primary fission fragment yield [Formula: see text], mass-dependent average neutron multiplicity [Formula: see text], energy-dependent average neutron multiplicity [Formula: see text] and neutron emission multiplicity distribution [Formula: see text] of [Formula: see text] for different neutron incident energy values, 1 MeV, 1.5 MeV, 3 MeV, 5.5 MeV, 7.7 MeV, 10 MeV, 14.8 MeV and 20 MeV, where the energy region is important for the reactor and accelerator systems used in the industry. The obtained results are compared with experimental data obtained from the literature and are discussed for each energy value.
Microbial insecticide model and homoclinic bifurcation of impulsive control system
Authors: Wang Tieying
Published: July 2021

A new microbial insecticide mathematical model with density dependent for pest is proposed in this paper. First, the system without impulsive state feedback control is considered. The existence and stability of equilibria are investigated and the properties of equilibria under different conditions are verified by using numerical simulation. Since the system without pulse has two positive equilibria under some additional assumptions, the system is not globally asymptotically stable. Based on the stability analysis of equilibria, limit cycle, outer boundary line and Sotomayor’s theorem, the existence of saddle-node bifurcation and global dynamics of the system are obtained. Second, we consider homoclinic bifurcation of the system with impulsive state feedback control. The existence of order-1 homoclinic orbit of the system is studied. When the impulsive function is slightly disturbed, the homoclinic orbit breaks and bifurcates order-1 periodic solution. The existence and stability of order-1 periodic solution are obtained by means of theory of semi-continuous dynamic system.
Chemical stratigraphy of subsurface lava flows from the Koyna (KBH1) core and correlation with the southwestern stratigraphy of the Deccan Traps
Authors: Sonu  , Kumar Amit , Satyanarayanan M. , Pathak Vamdev , Vedanti Nimisha , Shrivastava J. P.
Published: July 2021

The Koyna borehole penetrated
c.
1 km through the Deccan basalt units and into the cratonic basement beneath, thus providing a unique insight into the subsurface succession of the main Deccan province. Earlier studies focused on southwestern Deccan lava packages exposed in the Western Ghat escarpment, and resolved a well-constrained stratigraphy and key reference sections, but lacked supporting subsurface data. To construct the stratigraphy and correlate it with the main Deccan formations, we report flow-wise physical and chemical data of a
c.
932 m-thick core. We document 37 lava-flow units and four lava-flow groups that have similar major-oxide contents. These groups fit into two of the recognized chemostratigraphic formations, and the transitional Poladpur–Ambenali lavas. In addition, data plots on Ba v. Sr; Ba v. Zr/Nb; Ba/Y v. Zr/Nb; and Ba, Sr, Ba/Y, Zr/Nb v. height bivariate diagrams confine them to the Poladpur and Ambenali formations. Lava flows match with the Khumbarli and Mahabaleshwar Ghat sections and Killari core. The granitoid basement–basalt and the Poladpur Formation v. Ambenali Formation contacts lie at −332.5 and
c.
482 m above sea-level, respectively. Further, the new data endorse the southern overstepping of chemostratigraphic units and the asymmetry of the Deccan edifice due to the northward motion of the Indian Plate over the nascent Réunion plume (
c.
67–64 Ma). For comparison, the oldest 66.4 Ma lava flow predates the Cretaceous–Paleogene boundary (KPB) (66.052 Ma) by <0.35 Ma, with much of the Wai Subgroup erupted syn-KPB or >0.55 Ma post-KPB; however, the restricted lava thickness at the contact between the Poladpur and Ambenali formations provides a reference point in the Deccan stratigraphy.
Analyzing the Direct and Transitive Impact of Vulnerabilities onto Different Artifact Repositories
Authors: Düsing Johannes , Hermann Ben
Published: July 2021

In modern-day software development, a vast amount of public software libraries enable the reuse of existing implementations for reoccurring tasks and common problems. While this practice does yield significant benefits in productivity, it also puts an increasing amount of responsibility on library maintainers. If a security flaw is contained in a library release, then it may directly affect thousands of applications that are depending on it. Given the fact that libraries are often interconnected, meaning they are depending on other libraries for certain sub-tasks, the impact of a single vulnerability may be large, and is hard to quantify. Recent studies have shown that developers in fact struggle with upgrading vulnerable dependencies, despite ever-increasing support by automated tools, which are often publicly available. With our work, we aim to improve on this situation by providing an in-depth analysis on how developers handle vulnerability patches and dependency upgrades. To do so, we contribute a miner for artifact dependency graphs supporting different programming platforms, which annotates the graph with vulnerability information. We execute our application and generate a data set for the artifact repositories Maven Central, NuGet.org, and the NPM Registry, with the resulting graph being stored in a Neo4j graph database. Afterwards, we conduct an extensive analysis of our data, which is aimed at understanding the impact of vulnerabilities for the three different repositories. Finally, we summarize the resulting risks and derive possible mitigation strategies for library maintainers and software developers based on our findings. We found that NuGet.org, the smallest artifact repository in our sample, is subject to fewer security concerns than Maven Central or the NPM Registry. However, for all repositories, we found that vulnerabilities may influence libraries via long transitive dependency chains and that a vulnerability in a single library may affect thousands of other libraries transitively.
Mechanobiology of T Cell Activation: To Catch a Bond
Authors: Liu Baoyu , Kolawole Elizabeth M. , Evavold Brian D.
Published: July 2021

T cell activation is a critical event in the adaptive immune response, indispensable for cell-mediated and humoral immunity as well as for immune regulation. Recent years have witnessed an emerging trend emphasizing the essential role that physical force and mechanical properties play at the T cell interface. In this review, we integrate current knowledge of T cell antigen recognition and the different models of T cell activation from the perspective of mechanobiology, focusing on the interaction between the T cell receptor (TCR) and the peptide–major histocompatibility complex (pMHC) antigen. We address the shortcomings of TCR affinity alone in explaining T cell functional outcomes and the rising status of force-regulated TCR bond lifetimes, most notably the TCR catch bond. Ultimately, T cell activation and the ensuing physiological responses result from mechanical interaction between TCRs and the pMHC.
Components and Mechanisms of Nuclear Mechanotransduction
Authors: Niethammer Philipp
Published: July 2021

The cell nucleus is best known as the container of the genome. Its envelope provides a barrier for passive macromolecule diffusion, which enhances the control of gene expression. As its largest and stiffest organelle, the nucleus also defines the minimal space requirements of a cell. Internal or external pressures that deform a cell to its physical limits cause a corresponding nuclear deformation. Evidence is consolidating that the nucleus, in addition to its genetic functions, serves as a physical sensing device for critical cell body deformation. Nuclear mechanotransduction allows cells to adapt their acute behaviors, mechanical stability, paracrine signaling, and fate to their physical surroundings. This review summarizes the basic chemical and mechanical properties of nuclear components, and how these properties are thought to be utilized for mechanosensing.
[Retracted] A Chaotic Neural Network Model for English Machine Translation Based on Big Data Analysis
Authors: Cao Qianyu , Hao Hanmei
Published: July 2021

In this paper, the chaotic neural network model of big data analysis is used to conduct in‐depth analysis and research on the English translation. Firstly, under the guidance of the translation strategy of text type theory, the translation generated by the machine translation system is edited after translation, and then professionals specializing in computer and translation are invited to confirm the translation. After that, the errors in the translations generated by the machine translation system are classified based on the Double Quantum Filter‐Muttahida Quami Movement (DQF‐MQM) error type classification framework. Due to the characteristics of the source text as an informative academic text, long and difficult sentences, passive voice, and terminology translation are the main causes of machine translation errors. In view of the rigorous logic of the source text and the fixed language steps, this research proposes corresponding post‐translation editing strategies for each type of error. It is suggested that translators should maintain the logic of the source text by converting implicit connections into explicit connections, maintain the academic accuracy of the source text by adding subjects and adjusting the word order to deal with the passive voice, and deal with semitechnical terms by appropriately selecting word meanings in postediting. The errors of machine translation in computer science and technology text abstracts are systematically categorized, and the corresponding post‐translation editing strategies are proposed to provide reference suggestions for translators in this field, to improve the quality of machine translation in this field.
Developing a Novel Method for Estimating the Speed of Sound in Biodiesel Known as Grey Wolf Optimizer Support Vector Machine Algorithm
Authors: Lv Zhenzhen , Hu Ming , Yang Yixin , Makhdoumi Jeren
Published: July 2021

In the current study, our goal was to obtain a robust model to predict the speed of sound in biodiesel. For this purpose, an extensive databank has been extracted from previously published papers. Then, a Support Vector Machine (SVM) has been optimized by Grey Wolf Optimization (GWO) method to analyze these data and determine the correlation between speed of sound in biodiesel and its related properties including pressure, temperature, molecular weight, and normal melting point. The results were very satisfactory because the values of statistical parameters R2 and RMSE were obtained 1 and 1.4024, respectively. Here, this is the first time that the sensitivity analysis is used to estimate this target value. This analysis shows that the pressure widely affects the output values with relevancy factor 87.92. Also, our proposed method is highly accurate than other machine learning methods used in papers employed for this objective.
Effects of Electroacupuncture on Sleep via the Dopamine System of the HPA Axis in Rats after Cage Change
Authors: Xie Chen , Wang Jing , Zhao Na , Yang Wenjia , Gao Xiaolin , Liu Zhen , Chen Xinyu , Fang Chaojun , Fu Cong , Chen Yunfei , Yu Xintong
Published: July 2021

Background. Insomnia is often related to stressful events. The hypothalamus-pituitary-adrenal (HPA) axis is related to stress, and dopamine (DA) and DA receptors are involved in the regulation of HPA axis. Electroacupuncture (EA) can improve sleep in individuals with insomnia, but the mechanism is unclear. We demonstrated that EA can improve sleep in rats after cage change through DA and the DA receptors in the HPA axis. Methods. A rat model of insomnia was established by cage change to a dirty cage. The rats in treatment groups were intervened by EA and D1R (or D2R) antagonists. Electroencephalography (EEG) and electromyogram (EMG) were recorded to compare the changes in sleep. The DA, corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol (CORT) levels in the plasma and hypothalamus were measured by ELISAs, and the D1R and D2R levels were measured by RT-PCR and immunohistochemistry. Results. The dirty group showed a significant increase in the amount of wakefulness and decrease in the amount of NREM sleep, with decreased numbers of long NREM sleep bouts and REM sleep bouts and increased mean duration of wakefulness during the light period. EA and D1R (or D2R) antagonists intervention could improve sleep disturbance by decreasing wakefulness in the light period after cage change, EA and D1R (or D2R) antagonists could increase the hypothalamus DA, CRH, ACTH, CORT level, and the D1R and D2R mRNA levels in the HPA axis, and the effect of EA plus D1R (or D2R) antagonist was not superior to that of EA or D1R (or D2R) antagonists alone. Conclusions. EA can improve the sleep of rats after cage change, and the mechanism may be related to the regulation of DA and D1R or D2R in the HPA axis.