bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive factors for successful testicular biopsy
Authors: Brito Duarte Vieira , Lopes Manuel , Pereira Jose , Ferreira Ana Maria , Sousa Luis , Parada Belmiro , Figueiredo Arnaldo
Published: September 2023

Introduction: Infertility, the inability to conceive, constitutes a major problem in modern societies. It affects 10 to 15 percent of couples in the United States. Evaluation of infertile men is usually complex and often demands a testicular biopsy. Materials and methods: We reviewed all azoospermic men submitted to testicular biopsy, in our center, during infertility investigation between January 2015 and December 2021. Results: A total of 117 patients with a mean age of 36.5 was considered. Biopsy was positive, as defined by the presence of viable spermatozoids by microscopy, in 48.7% of patients (n = 57). Patients were divided in two separate groups based on positive (PB) or negative biopsy (NB) and compared. PB-group had normal serum total testosterone levels and higher than NB-group (3.7 ng/mL vs. 2.85 ng/mL, p = 0.021), and normal serum FSH levels and lower than NB-group (6.0 mIU/mL vs. 16.0 mIU/mL, p < 0.001). The groups were similar concerning serum LH levels (3.9 mIU/mL vs. 6.3 mIU/mL, p = 0.343. Conclusions: Predicting outcomes of testicular biopsy is a difficult task. Our study found that men with normal testicular volume, normal levels of testosterone and FSH and those with type 1 diabetes mellitus had a higher probability of positive testicular biopsy.
The outcome of ultrasound-guided insertion of central hemodialysis catheter
Authors: Abdo Ehab M. , Abouelgreed Tamer A. , Elshinawy Waleed E. , Farouk Nehal , Ismail Hassan , Ibrahim Amal H. , Kasem Samar A. , Sakr Lobna Kh. , Aboelsoud Naglaa M. , Abdelmonem Nermeen M. , Abdelkader Salma F. , Abdelwahed Ahmed A. , Qasem Anas A. , Alassal Mosab F. , Aboomar Ahmed A.
Published: September 2023

Objective: To point out our experience and assess the efficacy and safety of real-time ultrasound-guided central internal jugular vein (IJV) catheterization in the treatment of hemodialysis patients. Methods: This retrospective study comprised 150 patients with end-stage renal disease (ESRD) who had real-time ultrasonography (US)-guided IJV HD catheters placed in our hospital between March 2019 and March 2021. Patients were examined for their demographic data, etiology, site of catheter insertion, type (acute or chronic) of renal failure, technical success, operative time, number of needle punctures, and procedure-related complications. Patients who have had multiple catheter insertions, prior catheterization challenges, poor compliance, obesity, bony deformity, and coagulation disorders were considered at high-operative risk. Results: All patients experienced technical success. In terms of patient clinical features, an insignificant difference was observed between the normal and high-risk groups (p-value > 0.05). Of the 150 catheters, 62 (41.3%) were placed in high-risk patients. The first-attempt success rate was 89.8% for the normal group and 72.5% for the high-risk group (p = 0.006). IJV cannulation took less time in the normal-risk group compared to the highrisk group (21.2 ± 0.09) minutes vs (35.4 ± 0.11) minutes, (p < 0.001). There were no serious complications. During the placing of the catheter in the internal jugular vein, four patients (6.4%) experienced arterial puncture in the high-risk group. Two participants in each group got a small neck hematoma. One patient developed a pneumothorax in the high-risk group, which was managed with an intercostal chest tube insertion. Conclusions: Even in the high-risk group, the real-time US-guided placement of a central catheter into the IJV is associated with a low complication rate and a high success rate. Even under US guidance, experience lowers complication rates. Real-time USguided is recommended to be used routinely during central venous catheter insertion.
The Milan “mermaid”
Authors: Bagnasco Nicolò , Bardelli Giorgio , Garlaschelli Luigi
Published: September 2023

An ancient false “mermaid” kept at the Natural History Museum of Milan has been examined through X-rays and microscopic observations. It was possible to understand how this artifact was made. The Milan “mermaid” is one of several similar examples known for at least two centuries.
Effect of two types of charcoal toothpaste on the enamel surface roughness of permanent teeth
Authors: Yaghini Jaber , Moghareabed Ahmad , Hatam Faezeh , Keshani Forooz
Published: September 2023

Background:

Charcoal in the composition of some kinds of toothpaste has created concerns regarding abrasiveness and subsequent complications. Considering the popularity of charcoal toothpaste, and the manufacturers' claims that no porosity is caused by activated carbon, this study aimed to compare the effects of two charcoal kinds of toothpaste and three conventional tubes of toothpaste on enamel surface roughness of permanent primary teeth.

Materials and Methods:

This in vitro experimental study evaluated 75 teeth mounted in acrylic resin. Teeth were divided into five groups (n = 15). The primary surface roughness of teeth was measured by a profilometer. The teeth were then subjected to wear test in a V8 cross-brushing machine with Bencer and RP charcoal toothpaste, Crest 7, Colgate Optic White, and Bencer fresh mint toothpaste. After rinsing and drying specimens, their secondary surface roughness was measured. The mean changes in the roughness profile of specimens were analyzed by a one-sample Kolmogorov–Smirnov test at a 0.05 significance level.

Results:

There was no significant difference in the mean surface roughness of specimens before and after the wear test (P > 0.05). The difference in the mean wear of five types of toothpaste was not significant either (P = 0.597). The mean changes in surface roughness were 0.0685 μm for Bencer charcoal, −0.0620 μm for RP charcoal, 0.0765 μm for Crest 7, 0.1137 μm for Colgate Optic White, and 0.1052 μm for Bencer fresh mint toothpaste.

Conclusion:

Numerous kinds of toothpaste investigated in this study did not reveal any difference in terms of wear index; however, more studies are needed to evaluate the effectiveness and efficiency of these types of toothpaste.
The oncogenic role of NOTCH1 as biomarker in oral squamous cell carcinoma and oral lichen planus
Authors: Sadeghi Ensieh Sagheb , Nematpour Fatemeh Saeid , Mohtasham Nooshin , Mohajertehran Farnaz
Published: September 2023

Background:

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer with heterogeneous molecular pathogenesis. Oral lichen planus (OLP) is demonstrated potentially can transfer to OSCC malignant lesions. Unfortunately, there are no definitive prognostic and predictive biomarkers for the clinical management of OSCC patients. The present research is the first study that compared an oral premalignant lesion such as OLP to malignant lesions like OSCC for NOTCH1 expression levels to better understand its oncogenic or tumor suppressive role.

Materials and Methods:

In this cross-sectional study, mRNA expression of NOTCH1 was evaluated by quantitative polymerase chain reaction in 65 tissue-embedded Paraffin-Block samples, including 32 OSCC and 33 OLP. Furthermore, we collected demographic information and pathological data, including tumor stage and grade. The association between NOTCH1 and GAPDH gene expressions was determined by Chi-squared, Spearman, and Mann–Whitney tests. A P < 0.05 was considered statistically significant for all statistical analyses.

Results:

Comparison of OSCC and OLP groups showed a statistically significant difference between the quantitative expression of the NOTCH1 gene (P < 0.001). Qualitative gene expression was divided into low expression and high expression. Both study groups demonstrated a statistically significant gene expression difference (P < 0.001). There was a statistically significant difference between age and NOTCH1 expression in the OLP group (P = 0.036). There was no correlation between NOTCH1 expression and age, gender, tumor grade, and stage.

Conclusion:

Since the OSCC is a malignant lesion and the OLP showed the possible nature of malignancy transformation, we can consider the NOTCH1 as a biomarker for the assessment of the tumorigenesis process with a definition of a standard threshold for potentially malignant lesions and malignant OSCC tumors.
Aqueous extract of Protaetia brevitarsis larvae increases mTOR-mediated growth rate in zebrafish larvae
Authors: Jayasingha Jayasingha Arachchige Chathuranga Chanaka , Lee Kyoung Tae , Choi Yung Hyun , Kim Gi-Young
Published: September 2023

Objective:

To evaluate the effects of an aqueous extract of Protaetia brevitarsis (AEPB) on the growth of zebrafish and preosteoblast MC3T3-E1 cells.

Methods:

The effects of AEPB on the linear growth and the expression of growth-related genes in zebrafish and MC3T3-E1 cells were assessed using various molecular techniques. Furthermore, the involvement of the mammalian target of rapamycin (mTOR) pathway in AEPB-induced growth was investigated by employing the mTOR inhibitor rapamycin.

Results:

AEPB administration led to a significant and dose-dependent increase in zebrafish larvae growth over time. Additionally, AEPB treatment upregulated the expression of growth hormone-1 (GH-1), insulin-like growth factor-1 (IGF-1), growth hormone receptor-1 (GHR-1), and cholecystokinin-a (CCKA) in zebrafish. Similarly, AEPB stimulated the expression and release of IGF-1 and accelerated mTOR expression in MC3T3-E1 cells. In addition, rapamycin hindered AEPB-induced linear growth in zebrafish larvae and suppressed the expression of growth-promoting genes by inhibiting mTOR activation.

Conclusions:

AEPB shows growth-promoting effects by upregulating growth-related genes and activating the mTOR signaling pathway. Further investigations are warranted to elucidate its mechanisms of action and explore its potential application in the development of growth-enhancing supplements for various purposes.
Biochemical indicators and the Peradeniya Organophosphate Poisoning scale in prediction and prognosis of organophosphorus poisoning: An observational prospective study
Authors: Jelia Shivcharan , Lal Banwari , Airan Divya
Published: September 2023

Objective:

To study the value of some biochemical indicators and Peradeniya Organophosphate Poisoning scale in prediction and prognosis of organophosphorus poisoning.

Methods:

This was a hospital-based prospective, observational study. Various biochemical tests viz. complete blood count, random blood sugar, liver and renal function tests, creatine phosphokinase, and electrolytes were performed. Patients were assessed based on the Peradeniya Organophosphate Poisoning scale. All the patients were followed till the end point like recovery/death.

Results:

Out of the 100 patients, 72% were males and 28% were females. The majority of the patients were farmers and 21 to 30 years of age. Suicidal was the most common manner (92, 92%). Based on the Peradeniya Organophosphate Poisoning scale, 47% were mild, 34% moderate, and 19% severe. Serum creatinine, creatine phosphokinase, serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase, and alkaline phosphatase levels showed a significant correlation with severity.

Conclusions:

Some biochemical indicators such as creatine phosphokinase, alkaline phosphatase can be used as prognostic markers of organophosphorus poisoning. The Peradeniya Organophosphate Poisoning scale can be used for assessing severity of the poisoning.
Epidemiology of animal bite injuries in North of Fars province in Iran
Authors: Karami Hamed , Jafari Fatemeh , Jeihooni Ali Khani , Amiri Sanaz , Hashemifard Tahereh , Niknam Asadollah
Published: September 2023

Objective:

To investigate the epidemiological situation of animal bites in Rostam city of Fars province.

Methods:

This is a cross-sectional study. Cases of animal bites registered in health centers of Rostam city of Fars province from the beginning of 2014 to 2020 were analyzed using the census method. The tool for collecting information was the portal of the Ministry of Health and the registration offices of people who were referred to the rabies center.

Results:

A total of 628 cases of animal bites registered in health centers of Rostam city of Fars province from the beginning of 2014 to 2020. The mean age of the injured was (31.3 ± 20.2) years. Of the total injured cases, 414 (65.9%) were male, and 491 (78.2%) lived in villages. Most of the cases were bitten by dogs (n=420, 66.8%) and the upper limb was involved in 280 (55.2%) cases. In addition, an increasing trend was observed in the incidence of animal bites from 2015 to 2020.

Conclusions:

The incidence of animal bites in Rostam City is high, and most of the cases occur in rural areas. Considering the injuries caused by animal bites, the risk of rabies transmission, and the high costs of vaccination and serum therapy, it is necessary to hold control, educational, and vaccination programs.
The Spectrum of Inherited Gray Matter Degenerative Brain Disorders (DBD) in Children: A Single-Center Study
Authors: Prabhu Ram , Saini Arushi G. , Suthar Renu , Vyas Sameer , Malhi Prahbhjot , Attri Savita , Saini Lokesh , Sahu Jitendra K. , Sankhyan Naveen
Published: September 2023

Objectives:

To study the clinical spectrum of inherited gray matter degenerative brain disorders (DBD) in children.

Methods:

This cross-sectional study evaluated children up to 12 y of age, diagnosed with an inherited gray matter DBD in a tertiary care pediatric hospital between July 2019 and December 2020.

Results:

A total of 314 children with progressive neuroregression were screened. Of these, 117 children with inherited gray matter DBD were included in the study. The clinic-based prevalence of DBD was 8.2%, and inherited gray matter DBD was 3.1%. The proportion of the inherited gray matter DBD was 37.3% among the overall DBD cases. Children were categorized into three groups based on the age at onset of disease: below 2 years (N = 57, 48.7%), between 2 and 5 years (N = 32, 27.3%), and between 6 and 12 years (N = 28, 23.9%). Based on the predominant cerebral structure involved, gray matter DBD were classified as cerebral gray matter disorders (53%), basal ganglia disorders (34.1%), and cerebellar disorders (12.8%). Overall, the most common disorders were Wilson disease (18%), neuronal ceroid lipofuscinosis (NCL) (17%), and neurodegeneration with brain iron accumulation (NBIA) (16%). The most common gray matter DBD in children <2 years of age were NBIA (n = 11), Rett syndrome (n = 11), and gangliosidoses (n = 10). NCL (n = 14) and ataxia telangiectasia (n = 6) were most common in the age group of 2–5 years. Wilson disease (n = 19) was the most common disorder in the age group of 6–12 years followed by NCL (n = 4) and NBIA (n = 3).

Conclusion:

Our study highlights the burden and spectrum of gray matter DBD in children. The clinic-based prevalence of DBD was 8.2%, and of inherited gray matter DBD was 3.1%. The proportion of inherited gray matter DBD was 37.3% among the overall DBD cases. Wilson disease, NCL, and NBIA are the most common gray matter DBD in children. Timely diagnosis is important for the prevention of recurrence in subsequent pregnancies.
Ofatumumab, a Fully Human Anti-CD20 Monoclonal Antibody, in the Treatment of Severe Refractory Anti-N-methyl-D-Aspartate Receptor Encephalitis: Two Case Reports
Authors: Xue Hongfei , Jiang Yushu , Qin Lingzhi , Wang Xiaojuan , Zhang Milan , Dai Shuhua , Teng Yongshi , Xu Jiajia , Li Wei
Published: September 2023

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a type of autoimmune encephalitis (AE) characterized by antibodies against NMDA receptor. As the most common AE, anti-NMDAR encephalitis affects 54% ~ 80% of patients with AE. It is associated with a high percentage of severe illness. It typically manifests as behavioral and psychiatric disturbance, epilepsy, cognitive decline, decreased level of consciousness, involuntary movements, autonomic dysfunction, central hypoventilation, etc. We report two refractory anti-NMDAR encephalitis. One of them describes a case of anti-NMDA encephalitis coexisting with MOG antibodies. The two patients were administered first-line therapy with glucocorticoids and intravenous immunoglobulin but did not improve clinically. Therefore, the patient was switched to the fully human anti-CD20 monoclonal antibody, ofatumumab. Their consciousness, behavioral and psychiatric disturbance, and capacity to conduct daily tasks improved markedly after sequential therapy with ofatumumab, as demonstrated by the modified Rankin scale (mRS) score. For the first time, we report a successful approach to the treatment of refractory anti-NMDAR encephalitis using the fully human anti-CD20 monoclonal antibody ofatumumab, which serves as an important reference for the treatment of AE.
Molar Incisor Hypomineralization: Current Knowledge, Clinical Experience, and Perception among General Dental Practitioners, Pediatric Dentists, and Other Dental Specialists in Northern India – A Cross-sectional Study
Authors: Raj Shruti , Saha Sonali , Singh Gaurav , Dhinsa Kavita , Sharma Anshul , Sinha Pooja
Published: September 2023

Background:

Molar incisor hypomineralization (MIH) is the hypomineralization of systemic origin of one to four permanent first molars, frequently associated with affected incisors. It is presented as demarcated enamel opacities of different colors, occasionally undergoing posteruptive breakdown. The characteristic feature of MIH is the clear demarcation between the affected and sound enamel. There is an asymmetry of defects present in the molars and incisors where one molar or incisor can be severely affected, while the contralateral tooth may be clinically sound or have only minor defects.

Aim:

The study aimed to assess and compare the knowledge, perceptions, and clinical experience of general dental practitioners (GDPs), pediatric dentists (PDs), and other dental specialists (DSs) in Northern India about MIH.

Methodology:

Online survey methods were used to collect the responses from Northern Indian dentists regarding their knowledge and perceptions about MIH. The survey tool focused on participants’ sociodemographics, clinical experience, perceptions, clinical management, and preferences for further training. The level of knowledge regarding MIH was compared among the three groups. Data analysis utilized Chi-square and one-way analysis of variance followed by Tukey’spost hoctest using SPSS Statistics version 26.

Results:

The majority of respondents had observed MIH in their practice (77.3%). The participants who had a postgraduate degree had a significantly higher knowledge score value than GDPs (P< 0.001).

Conclusion:

Dissemination of evidence on MIH to dental practitioners, especially to GDPs, is highly needed to assure confidence in MIH diagnosis at an early stage when it can be best managed.
Impact of COVID-19 on Dental Practice in Kerala, India: A Qualitative Study
Authors: Raghunathan Dhanya , Ramakrishnan Devraj , Sreedevi Athira
Published: September 2023

Background:

Dentistry in India is facing many challenges owing to the increase in the number of dentists and meager job opportunities. As a majority of dental procedures are aerosol generating, the pandemic caused a huge impact on dental practice and education. Further, the risk of transmission of SARCoV-2 virus is high as the dentists work in close contact with the oral cavity. Thus, this study aims to explore the impact of COVID-19 on dental practice in Kerala.

Methodology:

A qualitative study was conducted among 31 dentists and 6 key administrative officials in Kerala through in-depth interviews, strictly adhering to the COREQ guidelines. The interviews were transcribed, translated, and analyzed manually.

Results:

Following inductive thematic analysis, seven themes emerged on “Impact of COVID-19 on Dentistry;” (1) Negative Impact of COVID-19 on Private Dental Clinic’s Income, (2) Negative Impact of COVID-19 on Government Dental Health Centers, (3) Negative Impact of COVID-19 on choice of Dental treatment Procedures, (4) Negative Impact of COVID-19 on Dental Education, (5) Positive impact of COVID-19 on Private Dental Clinics, (6) Positive Impact of COVID-19 on Professional Dental Associations, and (7) Positive impact of COVID-19 on dental health-care planning and timely implementation to assure the quality of care in future.

Conclusion:

A secured financial mechanism for dental practitioners, strong dental administration setup, increasing the quality of dental care by continuing the existing COVID treatment practices and improving the quality of dental education by implementing a strict protocol for conducting online classes, and employing more dentists, and dental auxiliaries in government health-care centers were identified as the measures to safeguard dentistry, especially during a pandemic.
Knowledge, Attitude, and Practice Regarding Oral Manifestations of COVID-19 among ASHA and Anganwadi Worker at Ghaziabad District – A Descriptive Study
Authors: Verma Sakshi , Gupta Ritu , Rohatgi Lavanya , Puri Nidhi , Tewari Sumit , Roy Jessica
Published: September 2023

Background:

There is a scarcity of affordable and available oral health services in developing countries which worsen the disease condition that eventually escalates the cost of treatment and care. Therefore, community health worker (CHW) can help to channelize the health care among population at ground level.

Objective:

This study was conducted to assess the knowledge, attitude, and practice regarding oral manifestation of coronavirus disease 2019 (COVID-19) among accredited social health activist (ASHA) and Anganwadi worker (AWW) of Ghaziabad district.

Methodology:

A cross-sectional, self-administered, and structured questionnaire was developed regarding the oral manifestation of COVID-19 and distributed among ASHA and AWWs in Ghaziabad district. The collected data were analyzed using the Chi-square tests in SPSS version: 23.

Results:

Majority of ASHA and AWW lack knowledge regarding oral manifestation of COVID-19 and need more information/training to create more awareness about oral manifestation of COVID-19. Mostly participants agreed that they did not spread oral health awareness before COVID-19.

Conclusion:

Additional training of oral health awareness during COVID-19 among these CHWs will help to prevent the oral-related disease at earliest reducing their adverse effects on overall health.
Assessing Perceived Emotional Social Support in Individuals with Schizophrenia or Schizoaffective Disorder: The Multisource Emotional Support Inventory
Authors: Jian Cian-Ruei , Chang Yu-Ping , Lin Chung-Ying , Yen Cheng-Fang
Published: September 2023

Background:

Emotional social support is a protective factor for mental health in individuals with schizophrenia or schizoaffective disorder. A comprehensive instrument should contain items for assessing perceived emotional social support from multiple sources. In this study, we intended to examine the psychometric properties of a newly developed instrument, namely, the Multisource Emotional Support Inventory (MSESI), for assessing perceived emotional support in individuals with schizophrenia or schizoaffective disorder.

Methods:

Exploratory factor analysis (EFA) was done to examine the factor structure of the MSESI. Cronbach’s α was used for examining internal consistency. Concurrent validity was evaluated using the Pearson correlations of the MSESI scores with depression, loneliness, family, and peer-support function, as well as the Community Integration Scale scores.

Results:

The EFA results indicated that the MSESI had a seven-factor structure, with the seven factors corresponding to the following subscales: perceived emotional support from parents, partners, offspring, relatives living with the respondent, relatives not living with the respondent, close friends in real life, and friends on the Internet. The MSESI had good internal consistency (Cronbach’s α ranging from 0.957 to 0.989). The entire MSESI had significant negative correlations with depression (r= –0.239;p< 0.001) and loneliness scales (r= –0.376;p< 0.001) and significantly positive correlations with family (r= 0.422;p< 0.001) and peer-support function (r= 0.430;p< 0.001) and community integration scales (r= 0.401;p< 0.001).

Conclusion:

Our results support the psychometric properties of the MSESI.
Mental and Physical Function Improvement through Lifestyle Modification: The Model of Environmental Protection Volunteer Project
Authors: Chen Wen-Chien , Cheng Chu-Fang , Chen Chia-Chi , Lee Jia-Fu
Published: September 2023

Objectives:

The environmental protection volunteer (EPV) project comprises EPV activities and low-intensity aerobic environmental protection health exercise (EPHE). The project covered “three doing” components, i.e., cognitive enhancement, physical activity, and social network. In this study, we intended to evaluate the effect of real-world EPV projects on mean blood pressure (BP) variability, cognition, and psychophysiological functions in the elderly.

Methods:

Totally, 79 older adult volunteers were recruited from the community environmental protection station. They were divided into three groups (low participation frequency group [LPFG], middle participation frequency group [MPFG], and high participation frequency group [HPFG]) based on the participation frequency. All participants were evaluated three times using the measurements, including visit-to-visit BP, cognitive (Mini–Mental State Examination [MMSE] and clinical dementia rating) and psychophysiological function brief Geriatric Depression Scale (GDS), pain Visual Analog Scale (VAS), and suffering VAS.

Results:

There was a significant increase in the MMSE and a decrease in pain VAS after participating in the EPV activity (p < 0.05). The diastolic BP variability (BPV) was significantly decreased after the EPV project containing EPHE (p < 0.01). Those who participated in HPFG and MPFG showed a significant decrease in the brief GDS compared with LPFG (p < 0.01 at T2 and p < 0.05 at T3).

Conclusion:

Participating in the EPV project benefited cognitive function and reduced pain and BPV. In addition, engaging in the EPV project frequently as a daily routine may reduce depression levels.
The Grief, Impact of Event and Coping Strategy among Doctors Working on COVID-19 Ward: An Online Survey in India
Authors: Bhalodia Bhavya S. , Shah Prathmesh U. , Chaudhary Pradhyuman , Mehta Prakash I. , Talati Shikha
Published: September 2023

Objectives:

In this cross-sectional study, we intended to assess grief, impact of event, and coping strategies of doctors who were working in the COVID-19 ward/intensive care unit (ICU), and to compare it with controls (people not working in COVID-19 ward/ICU).

Methods:

Online survey was done in the western state of India. Study participants completed structured quantitative interview for grief, Impact of Event Scale Revised and Brief Cope Inventory (BCOPE).

Results:

We found that 11 study doctors (9.8%) had severe grief (n = 112) and 28 controls (27.2%) had severe grief. We also found that 28 study doctors (25%) and 58 controls (56.3%) had a severe impact of event. Overall grief (t = −3.75) and impact of event (t = −5.07) were significantly higher in controls than doctors (p < 0.001). Hyperarousal type of impact of event significantly predicted grief in study doctors (β = 0.450, p < 0.01). A higher level of avoidance type of impact of the event (β = 0.430, p < 0.001), a higher level of seeking social support type of coping strategies (β = 0.190, p < 0.05), and lesser level of problem-solving type coping (β = −0.193, p < 0.05) significantly predicted a higher level of grief in controls.

Conclusion:

We found a clear evidence of higher grief and event impact in controls than in study doctors. In this study, doctors, who had experienced the hyperarousal type of impact of event predicted the development of grief, whereas, in controls, the avoidance type of impact of event predicted grief. In the study doctors, self-distraction and self-blame were the coping mechanisms associated with more severe grief, while coping with humor lessened grief. Self-blame coping increased grief in controls, and a higher seeking of social help and less problem-solving could predict grief. In the study of doctors, the most commonly used coping strategies were acceptance, positive reframing, and religion, while controls used acceptance, positive reframing, and active coping.
Case Series of Soft Tissue Sarcoma Patients with Brain Metastasis with Implications from Genomic and Transcriptomic Analysis
Authors: Park Changhee , Kim Rokhyun , Choi Jaeyong , Kim Miso , Kim Tae Min , Han Ilkyu , Kim Jong-Il , Kim Han-Soo
Published: September 2023

Purpose Brain metastasis rarely occurs in soft tissue sarcoma (STS). Here, we present five cases of STS with brain metastases with genetic profiles.Materials and Methods We included five patients from Seoul National University Hospital who were diagnosed with STS with metastasis to the brain. Tissue from the brain metastasis along with that from the primary site or other metastases were used for DNA and RNA sequencing to identify genetic profiles. Gene expression profiles were compared with sarcoma samples from The Cancer Genome Atlas.Results The overall survival after diagnosis of brain metastasis ranged from 2.2 to 34.3 months. Comparison of mutational profiles between brain metastases and matched primary or other metastatic samples showed similar profiles. In two patients, copy number variation profiles between brain metastasis and other tumors showed several differences including MYCL, JUN, MYC, and DDR2 amplification. Gene ontology analysis showed that the group of genes significantly highly expressed in the brain metastasis samples was enriched in the G-protein coupled receptor activity, structural constituent of chromatin, protein heterodimerization activity, and binding of DNA, RNA, and protein. Gene set enrichment analysis showed enrichment in the pathway of neuroactive ligand-receptor interaction and systemic lupus erythematosus.Conclusion The five patients had variable ranges of clinical courses and outcomes. Genomic and transcriptomic analysis of STS with brain metastasis implicates possible involvement of complex expression modification and epigenetic changes rather than the addition of single driver gene alteration.
Metal Additive Manufacturing in the Mobility Industry: Looking into
2033
Authors: Slattery Kevin , Coyne Jennifer
Published: September 2023

Now that metal additive manufacturing (MAM), also known as “metal 3D printing,”
has seen its first successful implementations across the mobility industry, the
question is whether it will continue to grow beyond these initial applications
or remain a niche manufacturing process. Moving to broader applications will
require overcoming several barriers, namely cost and rate, size, and criticality
limitations. Recent progress in MAM indicates that these barriers are beginning
to come down, pointing to continued growth in applications for MAM through the
end of the decade and beyond.

Metal Additive Manufacturing in the Mobility Industry: Looking into 2033
 discusses the obstacles to future MAM growth, how they can be conquered, and
what its role in the mobility industry will look like in 2033.

Click
here to access the full SAE EDGETM
Research Report portfolio.
Velej Paterkul: Rimska zgodovina (2.108–2.117.1)
Authors: Velej Paterkul  , Šimunić Tjaša
Published: September 2023

Velej Paterkul je bil rimski ekvit, vojaški poveljnik in senator, ki je svojo politično kariero opravljal pod Avgustom in Tiberijem. Vse, kar vemo o njem, nam je povedal sam v svojem zgodovinskem delu Historia Romana. Popisal je zgodovino vse do Tiberijeve vladavine, zaradi slabe ohranjenosti prve knjige pa je težko reči, kje je začel. Bil je prvi rimski zgodovinar, ki je svoje delo označil za transcursus, v katerem bo popisal samo najpomembnejše dogodke. Slednje na splošno opisuje bolj podrobno, če so bili bližje času, v katerem je pisal. Kljub temu da je Velejevo delo pravzaprav edino ohranjeno prozno delo iz časa Avgustove in Tiberijeve vladavine, je malo antičnih del, ki so jih tako v antiki kot kasneje citirali tako malo. Zanemarjali so ga predvsem zaradi njegovega navdušenja nad Tiberijem in njegovo vladavino.
Nekaj opažanj o antičnih virih za »pretenturo Italije in Alp«
Authors: Kovačič Blanka , Pobežin Gregor
Published: September 2023

Markomanske vojne so bile največji in najobsežnejši oboroženi spo­pad rimske vojske in barbarskih plemen ob osrednjem Podonavju – Markomanov, Kvadov in Sarmatov skupaj s še drugimi plemeni. Vojne z germanskimi plemeni so svoje prve kali kazale že v obdobju Antonina Pija, miroljubnega predhodnika Marka Avrelija, ki je težnje uzurpatorjev skrbno umirjal s konsistentnim pacifizmom. V Panonijo so prihajala poslanstva germanskih kraljevin izza Donave, ki so vznemirjala z vestmi o premikih barbarskih ljudstev s severa. Trgovanje barbarskih ljudstev z rimskimi državljani na mejah rimske države in migracije v germanskem bazenu plemen so v pasu ob limesu predstavljali težnje le-teh po dodatnem habitatu znotraj imperija. Apijan piše, da so poslanstva teh plemen prišla celo v Rim k cesarju Antoninu Piju in ga prosila za sprejem v imperij. Kontinuirani pritiski so eskalirali najverjetneje v l. 166, ko je bil velik del rimske garnizije stacioniran na vzhodni meji v boju s Parti. Limes je bil v tem obdobju slabo zavarovan, saj so bile čete legij, stacioniranih od Rena do Donave, poslane na fronto s Parti. Kljub prizadevanju cesarskih namestnikov v obeh Panonijah, da bi preprečili izbruh vojne na utrjeni državni meji z Donavo, je barbarom uspel preboj čez limes in posledično prodor vse do Akvileje in Opitergija. Boleča zavest o ranljivosti Italije, ki jo je avgustejski mir (Pax Romana) uspaval za več rodov, je prinesla nagel zasuk v obrambi. Pričujoče besedilo pretresa dva glavna vira za dogodke med germansko-sarmatsko vojno in postavlja vprašanja o odsotnosti omemb pomembnega obrambnega sistema, t.i. »Pre­tenture Italije in Alp«.
Numerical Methods for Solving Nonlocal Boundary Value Problems for Generalized Loaded Hallaire Equations
Authors: Бештоков М.Х.
Published: September 2023

Работа посвящена нелокальным краевым задачам для одномерных по пространству нагруженных уравнений Аллера с переменными коэффициентами и двумя операторами дробного дифференцирования Капуто с порядками $\alpha$ и $\beta$. Подобные задачи возникают в практике регулирования солевого режима почв, когда расслоение верхнего слоя достигается сливом слоя воды с~поверхности затопленного на некоторое время участка. Для численного решения поставленных задач на равномерной сетке построены разностные схемы. Методом энергетических неравенств при различных соотношениях между порядками дробной производной Капуто $\alpha$ и $\beta$ получены априорные оценки в дифференциальной и разностной трактовках для решений нелокальных краевых задач. Из~полученных априорных оценок следуют единственность и устойчивость решения по правой части и начальным данным, а также сходимость решения разностной задачи к решению соответствующей исходной дифференциальной задачи (в предположении существования решения дифференциальной задачи в классе достаточно гладких функций) со скоростью $O(h^2+\tau^2)$ при $\alpha=\beta$ и $O(h^2+\tau^{2-\max\{\alpha,\beta\}})$ при $\alpha\neq\beta$. В работе также приводится алгоритм численного решения нелокальной краевой задачи для нагруженного уравнения Аллера с переменными коэффициентами и оператором Бесселя.
Обобщение неравенств Островского на временных шкалах
Authors: Khan A.R. , Mehmood F. , Shaikh M.A.
Published: September 2023

The idea of time scales calculus’ theory was initiated and introduced by Hilger (1988) in his PhD thesis order to unify discret and continuous analysis and to expend the discrete and continous theories to cases ``in between''. Since then, mathematical research in this field has exceeded more than 1000 publications and a lot of applications in the fields of science, i.e., operations research, economics, physics, engineering, statistics, finance and biology. Ostrowski proved an inequality to estimate the absolute deviation of a differentiable function from its integral mean. This result was obtained by applying the Montgomery identity. In the present paper we derive a generalization of the Montgomery identity to the various time scale versions such as discrete case, continuous case and the case of quantum calculus, by obtaining this generalization of Montgomery identity we would prove our results about the generalization of the Ostrowski inequalities (without weighted case) to the several time scales such as discrete case, continuous case and the case of quantum calculus and recapture the several published results of different authors of various papers and thus unify corresponding discrete version and continuous version. Similarly we would also derive our results about the generalization of the Ostrowski inequalities (weighted case) to the different time scales such as discrete case and continuous case and recapture the different published results of several authors of various papers and thus unify corresponding discrete version and continuous version. Moreover, we would use our obtained results (without weighted case) to the case of quantum calculus.
ORMING OF THE BASICS OF SOVIET HEALTHCARE IN NORTH OSSETIA IN 1920-1930
Authors: РУБАЕВА Э.М.
Published: September 2023

В статье исследуется состояние здравоохранения в 1920-1930-е гг. в Северной Осетии. Целью данного исследования является выявление основных направлений становления, развития и функционирования органов здравоохранения, а также результатов их деятельности в Северной Осетии в первые десятилетия советской власти, в 1920-1930-е гг. Автор акцентирует внимание на позитивных процессах первых десятилетий советской власти в социальной сфере. Утверждается мысль о том, что на этапе социально-экономического, политического и культурного перелома страна совершила качественный прорыв и за короткий период времени заложила основы более высокой по сравнению с предыдущим периодом организации здравоохранения. За первые десятилетия советской власти произошли значительные изменения в оказании медицинской помощи населению. Дефицит бюджета советского государства, квалифицированных медицинских кадров сдерживали этот процесс. Приоритетом для советского здравоохранения стало оказание качественной медицинской помощи трудящимся слоям населения, которые ранее были ее лишены. Эти позитивные процессы во многом были связаны с тесным взаимодействием органов власти всех уровней и органов здравоохранения. Автор обосновывает мысль о том, что на этом этапе нашей истории шел процесс формирования подлинно социального государства.

The article is devoted to the study of the state of healthcare in the 1920s-1930s in North Ossetia. The purpose of this study is to identify the main directions of formation, development and functioning of health authorities, as well as the results of their activities in North Ossetia in the first decades of Soviet power, in the 1920-1930s. The author focuses on the positive processes of the first decades of Soviet power in the social sphere. The idea is affirmed that at the stage of the socio-economic, political and cultural turning point, the country made a qualitative breakthrough and in a short period laid the foundations for a higher foundation of health care compared to the previous period of time. During the first decades of Soviet power, there were significant changes in the provision of medical care to the population. The budget deficit of the Soviet state, qualified medical personnel held back this process. The priority for Soviet health care was the provision of quality medical care, namely, to the working strata of the population who had previously been deprived of it. These positive processes were largely associated with close interaction between authorities at all levels and health authorities. The author substantiates the idea that at this stage of our history there was a process of formation of a truly social state.
Analisis Positioning Operator Seluler dan Strategi Pemasaran Untuk Memenangkan Pasar di Wilayah Yogyakarta
Authors: Andi Yulianto  , Roni Roni , Setiadi Roby , Indriyani Azizah
Published: September 2023

Tujuan penelitian ini adalah untuk menentukan segmentasi pasar operator seluler dari tiga merek yaitu: Telkomsel, Mentari, dan XL. Ketiga merek tersebut mendominasi pasar operator seluler sehingga menarik untuk diteliti tentang peta persaingan terhadap atribut-atribut yang diberikan kepada konsumen. Sampel yang dipilih adalah pengguna dari ketiga merek operator seluler di Wilayah Sleman, Yogyakart sebanyak 140 responden. Jenis penelitian ini adalah penelitian kuantitatif. Metode analisis yang digunakan yaitu analisis faktor/klaster dan analisis korespondensi. Berdasarkan hasil output SPSS menghasilkan 3 (tiga) klaster, yaitu klaster 1 tentang layanan, klaster 2 tentang harga kartu perdana, dan klaster 3 tentang biaya telepon/SMS. Analisis korespendensi menghasilkan 4 kwadran yang membagi kelompok atribut-atribut yang diteliti
Pengaruh Cita Rasa dan Harga terhadap Keputusan Pembelian Kerupuk Udang Sinar Jaya Kaligangsa Brebes
Authors: Sari Fitri Novita , Mulyani Indah Dewi
Published: September 2023

Riset ini bermaksud untuk menerangkan pengaruh signifikan variabel Cita Rasa dan Harga pada Keputusan Pembelian. Riset ini dilaksanakan pada konsumen kerupuk udang Sinar Jaya Kaligangsa Brebes. Informasi Penelitian ini dikumpulkan melalui observasi, wawancara, dan kuesioner. Jumlah responden sebanyak 125 pelanggan kerupuk udang Sinar Jaya Kaligangsa Brebes. Metode analisis data riset ialah analisis regresi sederhana dan berganda dengan menggunakan SPSS 22.  Hasil uji regresi sederhana menunjukan bahwa cita rasa berpengaruh pada keputusan pembelian  melalui uji f dengan nilai signifikan sebesar 0,000 < 0,05, dan nilai f sebesar 43,239 > 2,68 (f tabel). variabel harga pada keputusan pembelian berpengaruh positif pada uji regresi sederhana dengan nilai signifikan 0,000 < 0,05, dan nilai f sebesar 81,949 > 2,68 (f tabel). Pada uji regresi berganda,variabel cita rasa dan harga berpengaruh positif pada keputusan pembelian secara serentak dengan besarnya nilai signifikan 0,000 < 0,05, dan nilai f hitung > f tabel ialah 49,705 > 2,68.
Analisis Kepercayaan dan Kepuasan terhadap Loyalitas Pelanggan Honda Motor
Authors: Yulianto Andi , Raharjo Budi
Published: September 2023

In the industrial world, customer loyalty is a measure of success in the manufacturing and sales industry. Customers will feel much more satisfied if the company can meet customer needs far beyond what is expected. Likewis with HONDA MOTOR, which emphasizes the evaluation of successful trust, and satisfaction through customer opinions filled by HONDA MOTOR customers. The loyalty of customers who are trying to achieve by HONDA MOTOR can be measured by distributing questionnaires to be filled out by customers. The sample in this study were 255 customers or HONDA MOTOR users. The questions in this questionnaire are closely related to employee promotions, employee service quality, customer trust, and customer satisfaction from the perspective of the perception of customer loyalty. The results of the answers to this questionnaire will be calculated to determine how much influence it has on customer loyalty. By knowing the results of this study related to customer loyalty, HONDA MOTOR can understand more deeply about customer views on promotion, service quality, trust and satisfaction and to determine the right strategy to improve performance in the future in order to achieve customer loyalty
PENGARUH KOMBINASI BAKSO DAGING IKAN LELE DAN DAGING AYAM DENGAN PENAMBAHAN ENZIM TRANSGLUTAMINASE
Authors: Alam Ali Nur , Wadli  , Hasdar Muhamad
Published: September 2023

harganya murah rasanya pun juga enak, penelitian ini bertujuan untuk mendapatkan hasil perlakuan terbaik dan mutu sesuai Setandar Nasional Indonesia (SNI) dari kombinasi daging ikan lele dan ayam yang ditambahkan enzim transglutaminase. Metode penelitian menggunakan Rancangan Acak Lengkap (RAL) dengan lima perlakuan dan tiga ulangan yaitu: PB1: (Daging ikan lele 200 gram Daging ayam 0 gram dan ditambah Enzim transglutaminase 6 gram), PB2 : (Daging ikan lele 150 gram Daging ayam 50 gram dan ditambah Enzim transglutaminase 6 gram), PB3 : (Daging ikan lele 100 gram Daging ayam 100 gram dan ditambah Enzim transglutaminase 6 gram), PB4 : (Daging ikan lele 50 gram Daging ayam 150 gram dan ditambah Enzim transglutaminase 6 gram), dan PB5 : (Daging ikan lele 0 gram Daging ayam 200 gram dan ditambah Enzim transglutaminase 6 gram). Parameter yang diuji adalah uji organoleptik meliputi warna, aroma, rasa, tekstur, uji lipat dan uji pH. Data hasil pengujian dianalisis menggunakan analisis sidik ragam atau (ANOVA) dan uji lanjut Duncan,s Multiple Range Test (DMRT). Hasil penelitian menunjukkan bahwa uji organoleptik, uji lipat dan uji pH, hasil beda nyata dan masih memenuhi syarat mutu bakso daging sapi SNI 01-3818-1995.
ANALISIS NILAI MORAL DALAM NOVEL LAYAR TERKEMBANG KARYA SUTAN TAKDIR ALISJAHBANA
Authors: Putriyanasari  , Ghufroni  , Khaliki Hernan , Indriyani Putri Bella , Khasanah Uswatun
Published: September 2023

Layar Terkembang adalah novel yang termasuk dalam novel Sutan Takdir Alisjahbana dan diterbitkan pertama kali pada tahun 1937 oleh Balai Pustaka. Novel itu berkisah tentang dua bersaudara antara Tuti dan Maria yang sama-sama mahasiswa kedokteran Tujuan penelitian ini yaitu untuk mendeskripsikan nilai-nilai moral yang berkaitan dengan manusia dan Tuhan, hubungan manusia dengan dirinya sendiri, dan hubungan manusia dengan manusia dalam novel Layar Terkembang karya Sutan Takdir Alisjahbana. Penelitian ini kami menggunakan metode deskriptif kualitatif. Dalam pengumpulan data menggunakan teknik simak dan catat yaitu dengan cara menyimak dan membaca Novel Layar Terkembang. Dari penelitian tersebut ditemukan 3 nilai moral yaitu 1) nilai moral hubungan manusia dengan tuhan tentang mempertanyakan tentang agama dan bertakwa kepada tuhan 2) nilai moral hubungan manusia dengan diri sendri terdiri dari 9 sikap yaitu, semangat, jujur, tidaak mudah kagum,sikap toleransi, sikap disiplin, kerja keras, tanggung jawab, kreatif, rasa ingin tahu 3) nilai moral hubungan manusia dengan manusia yang terdiri dari 3 sikap yaitu, sangat mencintai maria, sangat menyayangi yusuf, selalu menyemangati dan menghibur maria, dan kasih sayang dan perhatian seorang ayah pada anaknya.
BENTUK DAN FUNGSI GAYA BAHASA SINDIRAN DALAM ACARA SOMASI DI YOUTUBE
Authors: Ali Reza Ali Reza , Dina Nurmalisa
Published: September 2023

Penelitian ini bertujuan untuk mendeskripsikan bentuk dan fungsi gaya bahasa sindiran dalam acara Somasi di Youtube. Penelitian ini menggunakan metode penelitian kualitatif. Data berupa kata, kalimat dan wacana yang diujarkan komedian dalam acara Somasi yang diduga mengandung gaya bahasa sindiran, diambil melalui teknik purposive sampling, simak, dan catat. Teknik analisis data yang digunakan adalah analisis kualitatif. Ditemukan bahwa dalam acara Somasi penutur menggunakan gaya bahasa sindiran, yaitu ironi, sinisme, dan sarkasme. Selain itu, fungsi gaya bahasa sindiran dalam acara Somasi adalah fungsi kritik, menegur, menyadarkan, dan mengejek. Penyampaian sindiran dan kritik dalam acara tersebut menyinggung pemerintahan, tokoh publik, sosial, sara dan isu yang sedang hangat. Dari acara Somasi dapat dilihat bahwa komedi tidak hanya sebagai humor untuk menciptakan kelucuan saja, tetapi juga sebagai media penyampai keresahan, kritik, penolakan dan ketidak sepakatan yang semuanya dibalut dengan kemasan yang menarik, seperti bahasa, cara bercerita dan humornya.