bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Chronic Kidney Disease with Prior Tinnitus: A Case–Control Study
Authors: Hung Shih-Han , Xirasagar Sudha , Cheng Yen-Fu , Kuo Nai-Wen , Lin Herng-Ching
Published: December 2022

This population-based, case–control study aims to explore the relationship between prior tinnitus and the occurrence of chronic kidney disease (CKD) using a nationwide, population-based cohort study. We used data from the Taiwan National Health Insurance Research Database to explore the association of CKD with tinnitus. We identified 15,314 patients aged ≥40 years old with a first-time diagnosis of CKD as the cases. We used propensity-scored matching to select 45,942 controls (1:3 ratio). We performed multivariate logistic regression to estimate the odds ratio (OR) of a prior tinnitus diagnosis among the CKD group vs. the control group. Analysis showed that 770 (1.26%) out of the 61,256 sampled patients had previously diagnosed tinnitus. Chi-square testing revealed a significant difference in the rate of previously diagnosed tinnitus between cases and controls (3.86% vs. 0.93%, p < 0.001). Univariate logistic regression analysis showed an OR of prior tinnitus for cases of 10.249 (95% confidence interval (CI): (8.662~12.126)) relative to controls. In adjusted analysis, cases were more likely than controls to have a prior diagnosis of tinnitus (OR = 10.970, 95% CI = 9.255~13.004, p < 0.001) after adjusting for age, sex, monthly income, geographic location, urbanization level, hypertension, diabetes, coronary heart disease, hyperlipidemia, obesity, and autoimmune disease. Our study shows that CKD patients have a higher likelihood of having suffered from tinnitus before CKD was diagnosed, but we have no data suggesting that tinnitus is a predictor of subsequent CKD. Patients diagnosed with tinnitus may benefit from proactive measures to prevent CKD and detect it early through lifestyle modifications and regular renal function examinations, regardless of CKD-related symptoms.
Ileal Bile Acid Transporter Blockers for Cholestatic Liver Disease in Pediatric Patients with Alagille Syndrome: A Systematic Review and Meta-Analysis
Authors: Muntaha Hafiza Sidra tul , Munir Mubashar , Sajid Syeda Haleema , Sarfraz Zouina , Sarfraz Azza , Robles-Velasco Karla , Sarfraz Muzna , Felix Miguel , Cherrez-Ojeda Ivan
Published: December 2022

Alagille syndrome (ALGS) is a rare, debilitating inheritable disease that is associated with refractory pruritus due to chronic cholestasis. The following systemic review and meta-analysis presents the latest evidence for ileal bile acid transport (IBAT) blockers in AGLS patients in order to improve their efficacy. This study adhered to PRISMA 2020 Statement guidelines. A systematic search of PubMed/MEDLINE, Web of Science, Scopus, and the Cochrane library was conducted from inception until 23 October 2022. A combination of the following keywords was used: Alagille syndrome, therapeutics, treatment, therapy. Meta-analytical outcomes included effect directions of end-line changes in serum bile acids (sBAs), Itch Scale scores (ItchRO), Multidimensional Fatigue Scale scores, pediatric quality of life (QL), alanine aminotransferase (ALT), and total bilirubin. A total of 94 patients across four trials were enrolled and received maralixibat, odevixibat, or a placebo. There was a significant reduction in ItchRO scores by 1.8 points, as well as in sBAs by 75.8 μmol/L. Both the Multidimensional Fatigue Scale and Pediatric QL scale were also improved by 11.4 and 8.3 points, respectively. However, ALT levels were raised by 40 U/L. The efficacy of IBAT inhibitors across current trials was noted. Future trials may focus on the optimization of dosing regimens, considering gastrointestinal side effects and drug-induced ALT elevation in AGLS patients.
Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus
Authors: Chen Huixian , Wang Fan , Yang Ye , Hua Bingzhu , Wang Hong , Chen Jie , Feng Xuebing
Published: December 2022

Objective: To investigate the clinical characteristics of hearing loss (HL) in patients with systemic lupus erythematosus (SLE) and its related factors. Methods: Ninety-one hospitalized SLE patients and thirty healthy controls were enrolled. All subjects completed pure tone audiometry (PTA), extended high frequency audiometry (EHFA) and distortion product otoacoustic emission (DPOAE) to assess hearing function. SLE patients were divided into two groups according to the presence or absence of HL, and the risk factors of HL were determined by multivariate logistic regression. Results: The incidence of HL was 27.47% in SLE patients, significantly higher than in the control group (3.3%) and most cases were mild-to-moderate, bilateral and predominantly sensorineural. Compared with the control group, the hearing thresholds of SLE patients increased significantly in the middle and high frequencies starting from 2000 Hz. Even though the PTA test results were normal, the EHFA test results showed significant differences in hearing impairment between SLE patients and normal controls. For patients with abnormal PTA results, the signal-to-noise ratio (SNR) in DPOAE was markedly reduced, and the pass rate was also decreased. The Systemic Lupus International Collaborating Clinics Damage Index (SDI, OR 9.13) and secondary Sjögren’s syndrome (sSS, OR 8.20) were identified as independent associated factors for HL, and there was no difference in PTA and EHFA at all frequencies between hydroxychloroquine users and non-users. Conclusions: HL is not rare in SLE patients, and EHFA can help identify early hearing impairment. Having a high SDI score and secondary Sjögren’s syndrome may predict the presence of HL in SLE.
Increased Frequency of Hand Hygiene and Other Infection Prevention Practices Correlates with Reduced Surgical Wound Infection Rates in Spinal Surgery during the COVID-19 Pandemic
Authors: Perna Andrea , Maruccia Francesco , Gorgoglione Franco Lucio , Barletta Felice , Vitiello Raffaele , Proietti Luca , Tamburrelli Francesco Ciro , Santagada Domenico Alessandro
Published: December 2022

Background: Due to the COVID-19 pandemic outbreak, many changes were done in the hospital practice, and new guidelines were issued in order to contain the infection spread. One of the most common measures is represented by a correct and frequent hand washing. Recently, an association between increased adherence to hand hygiene (HH) protocols and reduction in hospital infections was documented however no studies about the surgical wound infection rate were reported in the Literature. Methods: The present study represents a multicentric retrospective epidemiological study. The HH compliance rate was recorded through direct observations by trained nurses, 24 h a day. The primary outcome was HH compliance rate. The association of HH with spinal surgical wound infections was the secondary outcome. Results: We reported a compliance to HH practices during the pandemic period of 85.2% compared with 57% observed during 2019. Our analysis showed an overall surgical wound infection reduction of 66.6% during the hospital stay in the pandemic period. Conclusion: Hand hygiene has always been considered one of the most effective, reproducible and low-cost weapons to deal with hospital infections. The good health habits acquired during the COVID-19 pandemic should be maintained even after the virus is eradicated.
Axial Spondyloarthritis: Reshape the Future—From the “2022 GISEA International Symposium”
Authors: Salaffi Fausto , Siragusano Cesare , Alciati Alessandra , Cassone Giulia , D’Angelo Salvatore , Guiducci Serena , Favalli Ennio , Conti Fabrizio , Gremese Elisa , Iannone Florenzo , Caporali Roberto , Sebastiani Marco , Ferraccioli Gian , Lapadula Giovanni , Atzeni Fabiola
Published: December 2022

The term “axial spondyloarthritis” (axSpA) refers to a group of chronic rheumatic diseases that predominantly involve the axial skeleton and consist of ankylosing spondylitis, reactive arthritis, arthritis/spondylitis associated with psoriasis (PsA) and arthritis/spondylitis associated with inflammatory bowel diseases (IBD). Moreover, pain is an important and common symptom of axSpA. It may progress to chronic pain, a more complicated bio-psychosocial phenomena, leading to a significant worsening of quality of life. The development of the axSpA inflammatory process is grounded in the complex interaction between genetic (such as HLA B27), epigenetic, and environmental factors associated with a dysregulated immune response. Considering the pivotal contribution of IL-23 and IL-17 in axSpA inflammation, the inhibition of these cytokines has been evaluated as a potential therapeutic strategy. With this context, here we discuss the main pathogenetic mechanisms, therapeutic approaches and the role of pain in axSpA from the 2022 International GISEA/OEG Symposium.
Bedside Ultrasound for Hemodynamic Monitoring in Cardiac Intensive Care Unit
Authors: Pastore Maria Concetta , Ilardi Federica , Stefanini Andrea , Mandoli Giulia Elena , Palermi Stefano , Bandera Francesco , Benfari Giovanni , Esposito Roberta , Lisi Matteo , Pasquini Annalisa , Santoro Ciro , Valente Serafina , D’Andrea Antonello , Cameli Matteo
Published: December 2022

Thanks to the advances in medical therapy and assist devices, the management of patients hospitalized in cardiac intensive care unit (CICU) is becoming increasingly challenging. In fact, Patients in the cardiac intensive care unit are frequently characterized by dynamic and variable diseases, which may evolve into several clinical phenotypes based on underlying etiology and its complexity. Therefore, the use of noninvasive tools in order to provide a personalized approach to these patients, according to their phenotype, may help to optimize the therapeutic strategies towards the underlying etiology. Echocardiography is the most reliable and feasible bedside method to assess cardiac function repeatedly, assisting clinicians not only in characterizing hemodynamic disorders, but also in helping to guide interventions and monitor response to therapies. Beyond basic echocardiographic parameters, its application has been expanded with the introduction of new tools such as lung ultrasound (LUS), the Venous Excess UltraSound (VexUS) grading system, and the assessment of pulmonary hypertension, which is fundamental to guide oxygen therapy. The aim of this review is to provide an overview on the current knowledge about the pathophysiology and echocardiographic evaluation of perfusion and congestion in patients in CICU, and to provide practical indications for the use of echocardiography across clinical phenotypes and new applications in CICU.
Comparing Different Algorithms for the Pseudo-Coloring of Myocardial Perfusion Single-Photon Emission Computed Tomography Images
Authors: Rahimian Abdurrahim , Etehadtavakol Mahnaz , Moslehi Masoud , Ng Eddie Y. K.
Published: December 2022

Single-photon emission computed tomography (SPECT) images can significantly help physicians in diagnosing patients with coronary artery or suspected coronary artery diseases. However, these images are grayscale with qualities that are not readily visible. The objective of this study was to evaluate the effectiveness of different pseudo-coloring algorithms of myocardial perfusion SPECT images. Data were collected using a Siemens Symbia T2 dual-head SPECT/computed tomography (CT) scanner. After pseudo-coloring, the images were assessed both qualitatively and quantitatively. The qualities of different pseudo-color images were examined by three experts, while the images were evaluated quantitatively by obtaining indices such as mean squared error (MSE), peak signal-to-noise ratio (PSNR), normalized color difference (NCD), and structure similarity index metric (SSIM). The qualitative evaluation demonstrated that the warm color map (WCM), followed by the jet color map, outperformed the remaining algorithms in terms of revealing the non-visible qualities of the images. Furthermore, the quantitative evaluation results demonstrated that the WCM had the highest PSNR and SSIM but the lowest MSE. Overall, the WCM could outperform the other color maps both qualitatively and quantitatively. The novelty of this study includes comparing different pseudo-coloring methods to improve the quality of myocardial perfusion SPECT images and utilizing our collected datasets.
Decentralized Documentation of Maritime Traffic Incidents to Support Conflict Resolution
Authors: Jankowski Dennis , Möller Julius , Wiards Hilko , Hahn Axel
Published: December 2022

For the investigation of major traffic accidents, larger vessels are obliged to install a voyage data recorder (VDR). However, not every vessel is equipped with a VDR, and the readout is often a manual process that is costly. In addition, not only ship-related information can be relevant for reconstructing traffic accidents, but also information from other entities such as meteorological services or port operators. Moreover, another major challenge is that entities tend to trust only their records, and not those of others as these could be manipulated in favor of the particular recording entity (e.g., to disguise any damage caused). This paper presents an approach to documenting arbitrary data from different entities in a trustworthy, decentralized, and tamper-proof manner to support the conflict resolution process. For this purpose, all involved entities in a traffic situation can contribute to the documentation by persisting their available data. Since maritime stakeholders are equipped with various sensors, a diverse and meaningful data foundation can be aggregated. The data is then signed by a mutually agreed upon timestamping authority (TSA). In this way, everyone can cryptographically verify whether the data has been subsequently changed. This approach was successfully applied in practice by documenting a vessel’s mooring maneuver.
Cryptococcus neoformans Causing Meningoencephalitis in Adults and a Child from Lima, Peru: Genotypic Diversity and Antifungal Susceptibility
Authors: Firacative Carolina , Zuluaga-Puerto Natalia , Guevara José
Published: December 2022

Cryptococcosis, caused predominantly by Cryptococcus neoformans, is a potentially fatal, opportunistic infection that commonly affects the central nervous system of immunocompromised patients. Globally, this mycosis is responsible for almost 20% of AIDS-related deaths, and in countries like Peru, its incidence remains high, mostly due to the annual increase in new cases of HIV infection. This study aimed to establish the genotypic diversity and antifungal susceptibility of C. neoformans isolates causing meningoencephalitis in 25 adults and a 9-year-old girl with HIV and other risk factors from Lima, Peru. To identify the genotype of the isolates, multilocus sequence typing was applied, and to establish the susceptibility of the isolates to six antifungals, a YeastOne® broth microdilution was used. From the isolates, 19 were identified as molecular type VNI, and seven as VNII, grouped in eight and three sequence types, respectively, which shows that the studied population was highly diverse. Most isolates were susceptible to all antifungals tested. However, VNI isolates were less susceptible to fluconazole, itraconazole and voriconazole than VNII isolates (p < 0.05). This study contributes data on the molecular epidemiology and the antifungal susceptibility profile of the most common etiological agent of cryptococcosis, highlighting a pediatric case, something which is rare among cryptococcal infection.
Arbuscular Mycorrhizal Fungus Alters Alfalfa (Medicago sativa) Defense Enzyme Activities and Volatile Organic Compound Contents in Response to Pea Aphid (Acyrthosiphon pisum) Infestation
Authors: Wang Yajie , Li Yingde , Tian Zhen , Duan Tingyu
Published: December 2022

Pea aphid (Acyrthosiphon pisum) infestation leads to withering, reduced yield, and lower quality of the host plant. Arbuscular mycorrhizal (AM) fungi have been found to enhance their host plants’ nutrient uptake, growth, and resistance to biotic stresses, including pathogen infection and insect pest infestation. Therefore, we evaluated the effects of AM fungus Rhizophagus intraradices on alfalfa defense responses to pea aphid infestation. Aphid infestation did not affect the colonization of AM fungus. The inoculation of AM fungus, on average, enhanced alfalfa catalase and the contents of salicylic acid and trypsin inhibitor by 101, 9.05, and 7.89% compared with non-mycorrhizal alfalfa, respectively. In addition, polyphenol oxidase activities significantly increased by six-fold after aphid infestation in mycorrhizal alfalfa. Moreover, the fungus significantly (p < 0.05) improved alfalfa shoot N content, net photosynthetic and transpiration rates, and shoot dry weight in aphid infected treatment. The aphid infestation changed the total volatile organic compounds (VOCs) in alfalfa, while AM fungus enhanced the contents of methyl salicylate (MeSA). The co-expression network analysis of differentially expressed genes (DEGs) and differentially expressed VOCs analysis showed that three DEGs, namely MS.gene23894, MS.gene003889, and MS.gene012415, positively correlated with MeSA both in aphid and AM fungus groups. In conclusion, AM fungus increased alfalfa’s growth, defense enzyme activities, hormones, and VOCs content and up-regulated VOC-related genes to enhance the alfalfa’s resistance following aphid infestation.
Phenylalanine Promotes Biofilm Formation of Meyerozyma caribbica to Improve Biocontrol Efficacy against Jujube Black Spot Rot
Authors: Deng Qian , Lei Xingmeng , Zhang Hongyan , Deng Lili , Yi Lanhua , Zeng Kaifang
Published: December 2022

During storage and transportation after harvest, the jujube fruit is susceptible to black spot rot, which is caused by Alternaria alternata. The present study aimed to evaluate the effectiveness of the yeast Meyerozyma caribbica in controlling A. alternata in postharvest jujube fruits, and to explore the biofilm formation mechanism. The results showed that M. caribbica treatment significantly reduced the A. alternata decay in jujube fruits. M. caribbica could rapidly colonize jujube fruit wounds, adhering tightly to hyphae of A. alternata, and accompanied by the production of extracellular secretions. In in vitro experiments, we identified that M. caribbica adhered to polystyrene plates, indicating a strong biofilm-forming ability. Furthermore, we demonstrated that M. caribbica can secrete phenylethanol, a quorum sensing molecule which can affect biofilm development. Phenylalanine (a precursor substance for phenylethanol synthesis) enhanced the secretion of phenylethanol and promoted the formation of M. caribbica biofilms. Meanwhile, phenylalanine enhanced the biological control performance of M. caribbica against jujube black spot rot. Our study provided new insights that enhance the biological control performance of antagonistic yeast.
Chemotherapeutic Potential of Saikosaponin D: Experimental Evidence
Authors: Manoharan Suryaa , Deivendran Bhuvaneshwari , Perumal Ekambaram
Published: December 2022

Saikosaponin D (SSD), an active compound derived from the traditional plant Radix bupleuri, showcases potential in disease management owing to its antioxidant, antipyretic, and anti-inflammatory properties. The toxicological effects of SSD mainly include hepatotoxicity, neurotoxicity, hemolysis, and cardiotoxicity. SSD exhibits antitumor effects on multiple targets and has been witnessed in diverse cancer types by articulating various cell signaling pathways. As a result, carcinogenic processes such as proliferation, invasion, metastasis, and angiogenesis are inhibited, whereas apoptosis, autophagy, and differentiation are induced in several cancer cells. Since it reduces side effects and strengthens anti-cancerous benefits, SSD has been shown to have an additive or synergistic impact with chemo-preventive medicines. Regardless of its efficacy and benefits, the considerations of SSD in cancer prevention are absolutely under-researched due to its penurious bioavailability. Diverse studies have overcome the impediments of inadequate bioavailability using nanotechnology-based methods such as nanoparticle encapsulation, liposomes, and several other formulations. In this review, we emphasize the association of SSD in cancer therapeutics and the discussion of the mechanisms of action with the significance of experimental evidence.
Development of a Prototype for a Bilingual Patient-Reported Outcome Measure of the Important Health Aspects of Quality of Life in People Living with HIV: The Preference Based HIV Index (PB-HIV)
Authors: Mate Kedar K. V. , Lebouché Bertrand , Brouillette Marie-Josée , Fellows Lesley K. , Mayo Nancy E.
Published: December 2022

(1) Background: The aim of this project was to develop a short, HIV-specific, health-related quality of life measure with a scoring system based on patient preferences for the different dimensions of the Preference-Based HIV Index (PB-HIV). (2) Methods: This study is a cross-sectional analysis of data from the Canadian Positive Brain Health Now cohort (n = 854; mean age 53 years). Items from the standardized measures were mapped to the areas from the Patient-Generated Index and formed the domains. A Rasch analysis was used to identify the best performing item to represent each dimension. Each item was then regressed on self-rated health (scored 0 to 100) and the regression parameters were used as scaling weights to form an index score for the prototype measure. (3) Results: Seven independent dimensions with three declarative statements ordered as response options formed the PB-HIV Index (pain, fatigue, memory/concentration, sleep, physical appearance/body image, depression, motivation). Regression parameters from a multivariable model yielded a measure with a scoring range from 0 (worst health) to 100 (perfect health). (4) Conclusions: Preference-based measures are optimal, as the total score reflects gains in some dimensions balanced against losses in others. The PB-HIV Index is the first HIV-specific preference-based measure.
Impact of Spino-Pelvic Parameters on the Prediction of Lumbar and Thoraco-Lumbar Segment Angles in the Supine Position
Authors: Schenk Philipp , Jacobi Arija , Graebsch Carolin , Mendel Thomas , Hofmann Gunther Olaf , Ullrich Bernhard Wilhelm
Published: December 2022

Background: The correction of malposition according to vertebral fractures is difficult because the alignment at the time before the fracture is unclear. Therefore, we investigate whether the spinal alignment can be determined by the spino-pelvic parameters. Methods: Pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), adjacent endplate angles (EPA), age, sex, body weight, body size, BMI, and age were used to predict mono- and bisegmental EPA (mEPA, bEPA) in the supine position using linear regression models. This study was approved by the Ethics Committee of the Medical Association of Saxony-Anhalt Germany on 20 August 2020, under number 46/20. Results: Using data from 287 patients, the prediction showed R2 from 0.092 up to 0.972. The adjacent cranial and caudal EPA showed by far the most frequently significance in the prediction of all parameters used. Anthropometric and spino-pelvic parameters showed sparse impact, which was frequently in the lower lumbar regions. On average, a very good prediction was found. For two mEPA (L3/4 R2 = 0.914, L4/5 R2 = 0.953) and two bEPA (L3 R2 = 0.899, L4 R2 = 0.972), the R2 was >0.8. However, the predicted EPA differed for individual patients, even in these very effective prediction models—roughly around ±10° as compared to the measured EPA. Conclusions: In general, the prediction showed good to perfect results. In the supine position, the spinopelvic and anthropometric parameters show sparse impact on the prediction of mEPA or bEPA.
PRLR and CACNA2D1 Impact the Prognosis of Breast Cancer by Regulating Tumor Immunity
Authors: Liang Jiamin , Deng Yu , Zhang Yubi , Wu Bin , Zhou Jing
Published: December 2022

Phosphatase and tensin homolog (PTEN) is one of the highly susceptible genes to breast cancer (BC); however, the role of PTEN-related RNAs in BC remains poorly understood. Understanding the effect of PTEN-related RNAs and their mechanisms may be helpful to clinicians. We screened the differentially expressed RNAs (deRNAs) related to PTEN and established the competitive endogenous RNA (ceRNA) network by integrating several databases. After that, the RNA model, prolactin receptor (PRLR)/calcium voltage-gated channel auxiliary subunit alpha2delta 1 (CACNA2D1), was obtained by KM survival analysis and logistic regression analysis. Finally, mutation, methylation, functional enrichment, and immune correlation were analyzed to explore the roles of these RNAs. Our results showed that PRLR might be harmful to BC, while CACNA2D1 might be beneficial to BC. Furthermore, the abnormal expression of PRLR in BC might result from mutation and hypomethylation, while the aberrant expression of CACNA2D1 might be ascribed to methylation. Mechanistically, PRLR might affect the prognosis of BC by inhibiting the expression of immune checkpoints, while CACNA2D1 might improve the prognosis of BC by increasing the immune cells infiltrating into BC and up-regulating the expression of immune checkpoints. The abnormal expression of PRLR and CACNA2D1 in BC is closely related to the prognosis of BC, and they may serve as targets for the treatment of BC.
Resveratrol Inhibits Oxidative Stress and Regulates M1/M2-Type Polarization of Microglia via Mediation of the Nrf2/Shh Signaling Cascade after OGD/R Injury In Vitro
Authors: Liu Jie , Liao Hongyan , Chen Yue , Zhu Huimin , Li Xuemei , Liu Jing , Xiang Qin , Zeng Fanling , Yang Qin
Published: December 2022

Aims: Microglia are closely related to the occurrence and development of oxidative stress. Cerebral ischemia leads to abnormal activation of microglia. Resveratrol can regulate M1/M2-type microglia polarization, but the underlying mechanism is not well understood, although the Nrf2 and Shh signaling pathways may be involved. Given that resveratrol activates Shh, the present study examined whether this is mediated by Nrf2 signaling. Methods: N9 microglia were pretreated with drugs before oxygen-glucose deprivation/reoxygenation (OGD/R). HT22 neurons were also used for conditional co-culture with microglia. Cell viability was measured by CCK-8 assay. MDA levels and SOD activity in the supernatant were detected by TBA and WST-1, respectively. Immunofluorescence detected Nrf2 and Gli1 nuclear translocation. The levels of CD206, Arg1, iNOS, TNF-α, Nrf2, HO-1, NQO1, Shh, Ptc, Smo, Gli1 protein and mRNA were measured by Western blotting or RT-qPCR. Annexin V-FITC Flow Cytometric Analysis detected apoptosis. Results: Resveratrol and Nrf2 activator RTA-408 enhanced the viability of microglia, reduced oxidative stress, promoted M2-type microglia polarization and activated Nrf2 and Shh signaling. ML385, a selective inhibitor of Nrf2, decreased the viability of microglia, aggravated oxidative stress, promoted M1-type microglia polarization and inhibited Nrf2 and Shh signaling. Moreover, resveratrol and RTA-408-treated microglia can reduce the apoptosis and increase the viability of HT22 neurons, while ML385-treated microglia aggravated the apoptosis and weakened the viability of HT22 neurons. Conclusions: These results demonstrated that resveratrol may inhibit oxidative stress, regulate M1/M2-type polarization of microglia and decrease neuronal injury in conditional co-culture of neurons and microglia via the mediation of the Nrf2/Shh signaling cascade after OGD/R injury in vitro.
The Role of E-Accounting Adoption on Business Performance: The Moderating Role of COVID-19
Authors: Lutfi Abdalwali , Alkelani Saleh Nafeth , Alqudah Hamza , Alshira’h Ahmad Farhan , Alshirah Malek Hamed , Almaiah Mohammed Amin , Alsyouf Adi , Alrawad Mahmaod , Montash Abdelhameed , Abdelmaksoud Osama
Published: December 2022

In the last decade, information systems (ISs) have made dynamic developments in light of their ability to enhance the performances of businesses. In relation to this, an organization that is effectively and efficiently managed often displays optimum performance using financial systems such as electronic accounting (e-accounting). Thus, essentially, e-accounting is utilized for the automation of operational processes and for improving business efficiency and performance. More currently, e-accounting dynamic development has laid credence to the performance of businesses in a way that the influence cannot be exaggerated. Nevertheless, past studies evidenced that successful e-accounting depends on critical success factors, and hence this study primarily aims to conduct an evaluation of e-accounting using DeLone and McLean’s information system model (DM ISM) among firms in Jordan. More specifically, this study determines the influence of information quality, system quality, service quality, system usage, and user satisfaction on business performance. The current study adopted a quantitative method, applying a self-administered survey questionnaire for the purpose of data collection from 104 e-accounting users. This study employed partial least squares structural equation modeling (PLS-SEM) to validate the data, and based on the findings, system quality and information quality affect system use; service quality of e-accounting had no significant impact on use, but e-accounting use had a significant influence on the satisfaction of users. Moreover, e-accounting system use and user satisfaction positively influence business performance. This study is an extension of the current IS literature, particularly of those focused on determining the effects of e-accounting benefits. This study validated the proposed model in the context of Jordanian firms and contributes to both the literature on and practice of e-accounting. This study provided implications, limitations, and recommendations for future research.
Why Partner with a Zoo or Garden? Selected Lessons from Seventy Years of Regional Conservation Partnerships at the Arizona-Sonora Desert Museum
Authors: Colodner Debra , Franklin Kim , Ivanyi Craig , Wiens John F. , Poulin Stéphane
Published: December 2022

Zoos and botanical gardens (ZBGs) play a variety of roles in regional conservation partnerships, including their most common role as the ex situ managers of rare plant and animal populations. Using case studies from a 70-year history of conservation work at the Arizona-Sonora Desert Museum in Tucson, Arizona, USA, this paper illustrates these roles and the characteristics of ZBGs that make them versatile and effective regional conservation partners. ZBGs commonly play the role of conservation advocates, as discussed in the context of the establishment of protected islands in the Gulf of California. ZBGs also conduct field research, including the collection of long-term datasets, as exemplified by the establishment of the Ironwood Forest National Monument and a 40-year Sonoran Desert phenology database. ZBGs can be effective conveners of communities and conservation partners in regional-scale efforts, such as the Sonoran Desert Conservation Plan and Cooperative Weed Management Areas. The paper also explores the challenges faced by ZBGs in sustaining their conservation work.
Ecological Niche Modelling and Potential Distribution of Artemisia sieberi in the Iranian Steppe Vegetation
Authors: Mirdavoudi Hamidreza , Ghorbanian Darush , Zarekia Sedigheh , Soleiman Javad Miri , Ghonchepur Mashaalaah , Sweeney Eileen Mac , Mastinu Andrea
Published: December 2022

Artemisia sieberi Besser occurs in many parts of the Irano-Turanian floristic region, which is mostly distributed throughout the Iranian plateau, especially in Iran. This study aimed to identify the effect of the soil and topography variables on A. sieberi distribution. We used canopy cover data to fit models using generalized additive models (GAMs). The results showed that the response pattern of A. sieberi along with the gradient of soil clay, soil saturation moisture, soil nitrogen and soil acidity followed the monotonic increase model, and its canopy cover percentage augmented by increasing the values of the factors. Conversely, the A. sieberi canopy cover percentage decreased by increasing the amount of soil sand, bare soil and the geographic aspect. The A. sieberi responses are in contrast to the niche theory. The relationship between the species response pattern and the gradients of soil silt, soil salinity, lime percentage, organic carbon, altitude, land slope, litter, gravel percentage, stone percentage, mean annual precipitation and mean annual temperature followed a unimodal model (consistent with the niche theory). The optimal growth limits for these factors were 32%, 1.75 ds/m, 35%, 1.3%, 2000 m, 43%, 10%, 32%, 250 mm and 15 °C, respectively. Our results highlight that environmental factors, such as soil texture, amount of soil lime, mean annual precipitation, altitude and land slope, had quantifiable effects on the performance of A. sieberi. Our findings could provide useful information for improvement, restoration and conservation programs. However, a further comprehension of the species–environment relationship is needed to predict the effects of climate change on the species habitat.
Evaluating Ecosystem Services for the Expansion of Irrigation on Agricultural Land
Authors: Estes Maurice , Cruise James , Ellenburg Walter , Suhs Rachel , Cox Alexandria , Runge Max , Newby Adam
Published: December 2022

Managing water resources requires consideration of both environmental and socio-economic benefits to effectively balance the benefits and costs. This includes identifying ecosystem services (ES) of concern and how to evaluate the project or proposed changes effect on these ES. The purpose of this effort is to describe methods to evaluate ecosystem services to provide expanded irrigation to existing agricultural lands in Alabama and the potential application to other areas. A case study has been undertaken on the Middle Alabama watershed in central Alabama and methods have been developed and applied to evaluate ES in terms of how irrigated versus rainfed fields will affect sediment retention, fertilizer usage and the effect of the subsequent discharges of sediment and nitrogen from fertilizer on water quality. The results of case studies in the Middle Alabama watershed indicate positive ES benefits from sustainable agricultural practices and the irrigation of agricultural lands versus rainfed fields. We anticipate these methods will be applicable to other watersheds outside the southeast region too.
An Experimental Study of the Social Dimension of Land Consolidation Using Trust Games and Public Goods Games
Authors: Tepnadze Matsatso , de Vries Walter Timo , Diaz Pamela Duran , Bichia Quji
Published: December 2022

Most land consolidation projects envisage reducing fragmentation and aim at increasing productivity, land use efficiency, and competitiveness of rural areas. However, recent insights suggest that social aspects are crucial as well. Hence, a critical assessment of the conditions under which land consolidation can be socially beneficial is necessary. This article aims to identify values and qualitative indicators to measure social preferences and to assess whether one can optimize decision support tools for land consolidation projects with such indicators. Based on an exploratory and concept-centric qualitative literature review, we propose game applications from experimental economics to measure empirical indicators of social capital. The games help to disclose conflicting social preferences and enable a more accurate response to public policy programs/interventions. This is achieved by assessing commonly shared norms of trust, reciprocity, and cooperation within and across social groups in a targeted area. We posit, however, the disparity among bonding, bridging, and linking dimensions of a social capital could have a differential effect on land consolidation instruments. This experimental method applied in Kakheti, Georgia reveals that 1. the farmer communities have varying combinations of bonding, bridging, and linking social capital; 2. the local farmer societies are the archetype of the collaborative model and sharing economy; 3. only a few municipalities show the highest potential for sustainably managing land consolidation projects. Hence, applying economic games that explore social scenarios helps to derive more favourable solutions for land consolidation.
Climate Change and Current Challenges for Landscapes and Cultural Heritage
Authors: Kazak Jan K. , Hodor Katarzyna , Wilkosz-Mamcarczyk Magdalena
Published: December 2022

Landscapes and cultural heritage have faced many challenges over time, including modifications and degradation that appear with time, overlap with other challenges not previously observed, and the influence of cities and management [...]
Assessing Project Proposals Based on National and Global Tiger Action Plans: Lessons from the Integrated Tiger Habitat Conservation Programme (ITHCP)
Authors: Diepstraten Johan , Sharma Mitali , Pasha Mohammad Khalid Sayeed , Roy Sugoto
Published: December 2022

Tigers play a crucial role in maintaining healthy ecosystems. Unfortunately, tigers are threatened by poaching, human–wildlife conflict, habitat loss, and more. In response to these threats, the conservation community pledged to double the worldwide wild tiger population by 2022 (known as TX2) at the “Tiger Summit” in St. Petersburg in 2010, and to track the progress of Tiger Range Countries. Between 2010 and 2022, the Global Tiger Recovery Programme was implemented. To accomplish this TX2 goal, each Tiger Range Country developed a National Tiger Action Plan (NTAP). The Integrated Tiger Habitat Conservation Programme (ITHCP) is a grant-making mechanism that focusses on a subsection of the Global Tiger Recovery Programme. It had twelve projects in six Tiger Range Countries during Phase 1 of the program. Evaluating the proposals of these projects is crucial for resource allocation. In this study, we assessed project proposals by evaluating how the proposed activities of all twelve ITHCP projects addressed their corresponding NTAPs, by comparing the plans against the proposals. A further comparison was undertaken using the Conservation Assured|Tiger Standards Lite, a site-based tiger conservation accreditation system. Overall, this study shows the importance of both global and national action plans and how comparing project activities with NTAP requirements can help address resource allocation needs to fill gaps in management. We conclude that projects should be designed to closely align with national action plans, best practice standards, and the activities of other projects in their landscape to maximize conservation outputs and impact. However, projects on their own are not enough to satisfy whole NTAPs.
Monitoring the Permafrost Conditions along Pipeline Routes in Central Yakutia, Russia
Authors: Varlamov Stepan , Skryabin Pavel , Zhirkov Aleksandr , Wen Zhi
Published: December 2022

Pipelines are critical infrastructure for Yakutia, transporting vital supplies to communities in this vast northern region. The pipeline routes in central Yakutia traverse areas of ice-rich permafrost that is sensitive to temperature changes. This study examined the thermal state of permafrost in undisturbed and disturbed settings along the Lena River to Mundulakh Reservoir water pipeline and the Mastakh to Yakutsk gas pipeline and considered the effects of climatic fluctuations and surface disturbances (forest removal and wildfire) over the monitoring periods of 28 and 18 years, respectively. The geocryological conditions in the study area, as well as the methods of permafrost thermal monitoring, are described. The observation results demonstrated significant increases in the mean annual ground temperature in the upper permafrost layers, as well as in the active-layer thickness following fire and post-fire clearing. At some sites, progressive deepening of the active layer caused the formation of taliks and reached the top of massive ground ice, initiating permafrost degradation. The development of extreme ground temperatures in the layer of annual temperature fluctuations was analyzed according to the combination of seasonal and annual meteorological conditions and the type of anthropogenic impact. The research results can be extrapolated to similar anthropogenic landscapes.
Pesticide Residues and Heavy Metals in Vineyard Soils of the Karst and Istria
Authors: Vrščaj Borut , Česnik Helena Baša , Velikonja Bolta Špela , Radeka Sanja , Lisjak Klemen
Published: December 2022

Pesticide residues and heavy metal concentrations were determined in two depths (0–20 and 20–40 cm) of Chromic Cambisol in 69 vineyards in the Slovenian winegrowing region of the Karst. Similarly, pesticide residues and heavy metal concentrations were also determined in two depths of Calcaric Cambisol in 11 vineyards in the other Slovenian and Croatian winegrowing regions of Istria. The topsoil (0–20 cm) was analysed for the presence of 176 different pesticidal active substances using two multiresidue analytical methods: (a) gas chromatography coupled with mass spectrometry (GC/MS) and (b) liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS). Seven active substances (five fungicides and two insecticides) were detected in the soil samples. Their concentrations were compared with the maximum concentrations observed in the vineyards of the winegrowing regions of France, Italy, and Spain. In addition to pesticides, the soil samples were analysed for the presence of nine heavy metals commonly detected in vineyard soils. The concentrations of arsenic, cadmium, cobalt, chromium, copper, molybdenum, nickel, lead, and zinc were below the critical thresholds set by Slovenian legislation, with the exception of one soil sample in which the Cu concentration exceeded the critical threshold. Compared with the maximum concentrations measured in other vineyard soils in Spain, Italy, and France, the heavy metal concentrations in the vineyard soils of Karst and Istria were lower. Both the heavy metal concentrations and the residual concentrations of pesticidal active substances in the vineyard soils of the Karst and Istria regions were significantly lower than the concentrations that are occasionally discussed in the literature.
Harms to Community Food Security Resulting from Gender-Based Violence
Authors: Okpara Uche , Anugwa Ifeoma
Published: December 2022

While the right to food and community self-reliance underpin current knowledge and interpretation of community food security (CFS), the literature on CFS seldom accounts for the ways in which gender-based violence (GBV) disrupts and undermines CFS. In this review, we make the case that GBV in CFS contexts manifests as a continuum, involving different forms of violence that blend into and reinforce each other, fueling social degradation and undermining the capacity of community food system workers to prioritise and pursue CFS. We show that harms to CFS resulting from GBV manifest through (i) GBV-induced social degradation, (ii) erosion of moral and ethical values anchoring CFS, (iii) disruption of crucial food systems sustainability pathways to CFS, (iv) the challenges, behaviours and activities of community food system workers, and (v) the crippling of community-level on-farm and off-farm food value chains, which oftentimes disrupt food access, consumption and utilisation. We further outline that the diversion of CFS funds into GBV prevention services may reduce CFS-related economic outputs and that CFS efforts that are GBV-blind can undermine the agency of community food system workers, pushing them into decisions that undermine CFS. We conclude that there is a dearth of information on how to mainstream GBV-sensitivity into CFS plans, and it is unclear whether GBV-responsive CFS initiatives can enhance the legitimacy of CFS efforts in GBV-exposed settings. We suggest that the spectrum of what is considered “community” in relation to CFS be expanded; and that scholars and practitioners pay attention to the dynamics of GBV, focusing on how GBV occurring at individual and household levels spills over into communities to undermine CFS. Finally, since GBV is not only a human rights violation issue but also a catalyst for social degradation and food insecurity, we encourage refocusing CFS efforts to prioritise early detection and prevention of GBV across specific community-level, on-farm and off-farm food value chains in order to better enhance community ties and foster food security.
Microbiota of the Colonic Diverticula in the Complicated Form of Diverticulitis: A Case Report
Authors: Yarullina Dina , Pankratova Yuliia , Karaseva Olga , Grigoryeva Tatiana , Karpukhin Oleg
Published: December 2022

Intestinal microbiota appears to be implicated in the pathogenesis of diverticular disease. We present the case of a patient with diverticular colon disease complicated by a pelvic abscess. During the successful surgical treatment, two specimens were taken from the resected colon segment for the microbiota analysis: an inflamed and perforated diverticulum and a diverticulum without signs of inflammation. Culturing and 16S rRNA gene sequencing revealed significant changes in the microbial community structure and composition associated with the acute inflammation and perforation of the colonic diverticulum. The characteristics that are usually associated with the inflammatory process in the gut, namely reduced microbial diversity and richness, decreased Firmicutes-to-Bacteroidetes (F/B) ratio, depletion of butyrate-producing bacteria, and Enterobacteriaceae blooming, were more pronounced in the non-inflamed diverticulum rather than in the adjacent inflamed and perforated one. This is the first study of the intraluminal microbiota of the diverticular pockets, which is more relevant to the etiology of diverticular disease than mucosa-associated microbiota via biopsies and luminal microbiota via fecal samples.
A Comparative Study of Stone Re-Treatment after Lithotripsy
Authors: Chiou Yueh-Er , Chung Chi-Hsiang , Chien Wu-Chien , Tsay Pei-Kwei , Kan Hung-Cheng , Weng Wen-Hui
Published: December 2022

The high recurrence rate has always been a problem associated with urolithiasis. This study aimed to explore the effectiveness of single interventions, combined therapies, and surgical and nonsurgical interventions. Herein, three lithotripsy procedures—extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotomy (PCNL), and ureteroscopic lithotripsy (URSL)—were assessed and a retrospective cohort was selected in order to further analyze the association with several risk factors. Firstly, a population-based cohort from the Taiwan National Health Insurance Research Database (NHIRD) from 1997 to 2010 was selected. In this study, 350 lithotripsy patients who underwent re-treatment were followed up for at least six years to compare re-treatment rates, with 1400 patients without any lithotripsy treatment being used as the comparison cohort. A Cox proportional hazards regression model was applied. Our results indicate that the risk of repeat urolithiasis treatment was 1.71-fold higher in patients that received lithotripsy when compared to patients that were not treated with lithotripsy (hazard ratio (HR) 1.71; 95% confidence interval (CI) = 1.427–2.048; p < 0.001). Furthermore, a high percentage of repeated treatment was observed in the ESWL group (HR 1.60; 95% CI = 1.292–1.978; p < 0.001). Similarly, the PCNL group was also independently associated with a high chance of repeated treatment (HR 2.32; 95% CI = 1.616–3.329; p < 0.001). Furthermore, age, season, level of care, and Charlson comorbidities index (CCI) should always be taken into consideration as effect factors that are highly correlated with repeated treatment rates.