bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical investigation of photovoltaic solar system performance for a high-speed ship
Authors: Elkafas Ahmed G.
Published: January 2024

Maritime transportation has a remarkable contribution to the increase of pollutant gases in the atmosphere and adapting alternative energy systems to ship’s main power grid is an effective method to both save energy and reduce the amount of emission gases. The concept of green shipping is now becoming an important issue for ship owners, shipping lines, and shipbuilders globally. Solar energy may supply an environmentally friendly part of the total energy balance of a ship. Egypt is in the world’s solar belt and has excellent solar energy availability. Therefore, the present work aims to present a case study for installing a photovoltaic solar system onboard a passenger/Ro-Ro ship sailing between Safaga Port in Egypt and Yanbu Port in Saudi Arabia. Meteorological data for Safaga and Yanbu sailing route is presented to calculate the output power of that system. The proposed ship is designed to accommodate 843 passengers and 227 cars. The solar system onboard the ship has been modeled based on the available weather deck and bridge deck areas. The solar system will be composed of 1229 solar panels with 565 batteries. The proposed solar system will produce 1625 kWh/day used for the hoteling system of the ship. As a result of the calculations, 0.333 tons of low Sulphur fuel oil is saved in a day by the generators over the designed solar system. It is found significant environmental impacts within the calculation. By adopting such a solar system to the vessel, it is determined that there is a decrease of 0.27 tons of SOx, 7 tons of NOx, 415 tons of CO2, and 0.18 tons of PM emission that occur during the operations annually. A cost analysis is conducted to assess the economic benefits of the installed system. It shows that the proposed solar system will save 326,000 $ per year in addition to being clean to the environment, less emissions, and green ship.
Olay Sıra Çizgeleri için Alana Özgü Bir Dil
Authors: KALECİK Mert , TUĞLULAR Tuğkan , BELLİ Fevzi
Published: January 2024

Yazılımın kalitesi, güvenilir ve hatasız yazılım çözümleri sunabilmek için ulaşılması gereken temel parametrelerden biridir. Sıklıkla model tabanlı testlerle kendini gösteren sistematik test yaklaşımı, yazılım kalitesini artırmak için kullanılan bir yöntemdir. Model tabanlı test yaklaşımına örnek olarak Olay Sıra Çizgeleri (OSÇ) verilebilir. Alana özel dil (AÖD), sınırlı bir alanda geliştirim sürecinde önemli avantajlar sağlayan bildirimsel bir dildir. Bu araştırma karar tablosuyla güçlendirilmiş hiyerarşik OSÇ tasarlama ve görselleştirme için OSÇ-AÖD adı verilen alana özgü bir dil geliştirmeye odaklanmaktadır. Değerlendirme amacıyla bir odak grubu ile çalışılmış ve belli senaryolar için hem Test Suite Designer (TSD) aracı ile hem de OSÇ-AÖD ile OSÇ’ler oluşturulmuştur. Odak grubuna uygulanan anket yoluyla elde edilen karşılaştırma sonuçları, OSÇ-AÖD yaklaşımının TSD yaklaşımına göre kolay kullanım ve tekrar kullanılabilirlik gibi bazı iyileştirmeler içerdiğini göstermektedir.
KVKK Kavramlarının Modellenmesi için Ontoloji Tabanlı Bir Yaklaşım
Authors: ATLIER OLCA Emre , CAN Özgü
Published: January 2024

Bilgi ve iletişim teknolojilerinin hızlı gelişimi kişisel verilerin paylaşılmasını ve daha kolay yayılmasını sağlamaktadır. Kişisel verilere olan erişim kolaylığı, kişisel mahremiyeti ve veri güvenliğini tehdit etmektedir. Veri gizliliğini ve güvenliğini sağlamak için 2016 yılında 6698 sayılı Kişisel Verilerin Korunması Kanunu (KVKK) kabul edilmiştir. Anayasa’nın 20. maddesi, Türk Ceza Kanunu, Türk Medeni Kanunu gibi bazı yasal çalışmalarda kişisel verinin korunmasına yönelik maddeler bulunsa da konuyu bütüncül olarak ele alan tek çalışma 6698 sayılı kanundur. Bu kanuna göre, kişisel verinin kullanımı kişinin onamına bağlıdır. Etkili bir onam yönetiminin sağlanabilmesi için veriye erişim bilgilerini ve erişim kurallarını tutan politikaların paylaşımı gereklidir. Bu çalışma kapsamında, Genel Veri Koruma Tüzüğü (General Data Protection Regulation - GDPR) ve KVKK kavramları karşılaştırılmakta ve KVKK metni analiz edilerek KVKK kavramları çıkarılmaktadır. Ayrıca, KVKK kavramlarını temel alan onam modeli ontoloji tabanlı bir yaklaşım ile geliştirilmekte ve Anlamsal Web teknolojileri tabanlı bir onam yönetim sistemi önerilmektedir.
In-Vitro Bioactivity Evaluation of Hydrangenol Extracted from Hydrangea macrophylla (Thunb.) Ser. Leaves
Authors: AL-YAFEAİ Ahlam , SCHMİTT Barbara , MALARSKİ Angelika , BÖHM Volker
Published: January 2024

Hydrangea macrophylla plant, native to Japan and Korea, has been attracting scientific attention due to its potential applications in both food science and health-related research. In this investigation, dry Hydrangea leaves were utilized as the source material. Subsequent to comminution and thermal treatment at 70 °C for an 18-hour duration, followed by a 30-minute ultrasonic bath extraction and a 5-minute centrifugation at 5000 rpm, hydrangenol was isolated through preparative HPLC. The investigation involved assessing the antioxidant capacity of hydrangenol, its impact on the activity of α-amylase and α-glucosidase enzymes, and its ability to prevent enzymatic browning. Quantification of antioxidant capacity, determined through TEAC (Trolox Equivalent Antioxidant Capacity), showed values from 1.8 to 3.2 mmol TE/mmol. Likewise, the ORAC (Oxygen Radical Absorbance Capacity) values were in the range of 16.5-27.0 mmol TE/mmol. Total phenolics content (Folin-Ciocalteu test) yielded a range of 7.1-11.2 g GAE (Gallic Acid Equivalents) per 100 g. Examining α-amylase inhibition, hydrangenol demonstrated a 52% inhibition (IC50: 3.6 mg/mL), whereas acarbose (positive control) displayed a higher inhibition of 99 % (IC50: 0.51 mg/mL). Regarding α-glucosidase inhibition, hydrangenol exhibited a 51% inhibition (IC50: 0.97 mg/mL), while acarbose displayed a 46% inhibition (IC50: 2.1 mg/mL). Additionally, the activity of PPO was suppressed by 61% at hydrangenol concentrations of 1 mg/mL and 2 mg/mL, and by 46% at a concentration of 4 mg/mL.
Foreign investor portfolio flow and monetary policy response in the Indonesian stock market considering the COVID-19 pandemic
Authors: Subagyo Herry , Hersugondo Hersugondo , Marcellino Candra Wijaya , Lumban Batu Kardison , Eko Waluyo Dwi
Published: January 2024

Foreign portfolio investment in developing countries, including Indonesia, plays a crucial role in the economy, where this fund flow can influence exchange rates and stimulate price increases in the stock market. During the COVID-19 pandemic, the volatility of foreign portfolio flows by investors has significantly increased. To anticipate these conditions, the monetary authorities in Indonesia have implemented various monetary policies to address the possibility of more adverse situations. This study examines the impact of the inflow or outflow of foreign portfolio investments and the monetary policies reflected in the 7-day repo rate of Bank Indonesia on the Indonesian stock market. The data were collected from April 4, 2016, to March 18, 2022. The research methodology involves the Non-Linear Autoregressive Distributed Lag and the Markov Switching Regression (MSR) model. The findings indicate that foreign investor portfolio flows influence the Jakarta Composite Index. There is a tendency for domestic investors to analyze the habits of foreign investors. The study also found that monetary policy is not proven to affect the Jakarta Composite Index, while the USD/IDR exchange rate has an impact on the Indonesian stock market. This indicates many companies listed on the Indonesia Stock Exchange have debt in dollars or are paid in US dollars, making them vulnerable to exchange rate fluctuations.
Orta Anadolu-Sivas’ta Paleolitik Çağ Kalıntıları
Authors: AÇIKKOL Ayşen , BAYKARA İsmail , GÖKKURT Sevgi Tuğçe , AY Faruk
Published: January 2024

Bu çalışmanın konusu, 2016-2019 yılları arasında Orta Anadolu’da konumlanan Sivas iline bağlı Divriği, Kangal, Gürün ve Altınyayla ilçelerinde gerçekleştirilen Pleistosen Dönem yüzey araştırmasının sonuçlarını değerlendirmektir. Çalışmanın amacı, yontmataş buluntular, mağaralar, kaya altı sığınakları ve hammadde kaynaklarını tespit etmek ve bulguları Türkiye Paleolitik stratigrafisine eklemektir. Araştırmada “yaya yüzey araştırması yöntemi” kullanılmıştır. Paleolitik dolguların belirlendiği alanlarda yontmataş buluntular toplamış ve tanımlamalar yapılmıştır. Yontmataş buluntular öncelikle Paleolitik dönemlere göre ayrılmıştır ve yontmataş buluntuların teknolojik-tipolojik tanımlamaları yapılmıştır. Araştırmada 16 paleolitik alan tespit edilmiş ve 236 yontmataş tanımlanmıştır. Paleolitik dolgu içeren mağara ya da kaya altı sığınağı bulunamamış ancak Divriği, Kangal ve Gürün’ün volkanik kayaçlar ve çakmaktaşı açısından çok zengin olduğu kaydedilmiştir. Taş aletlerin teknolojik ve tipolojik analizleri, Divriği’de volkanik kayaçların kullanıldığı, Mod 1 endüstrisine benzerlik gösteren bir Alt Paleolitik kültürünün varlığını; Kangal, Gürün ve Altınyayla’da hammadde olarak çakmaktaşının tercih edildiği Orta Paleolitik ve Geç Üst Paleolitik (belki Epipaleolitik) kültürlerinin mevcut olduğunu göstermiştir. Sivas Orta Paleolitik kültürü, Hatay’dan çok Karain Mağarası’nın Orta Paleolitik buluntuları ile benzerlik göstermektedir. Buluntular in-situ olmadığı için radyometrik tarihlendirme yapılamamıştır. Bu çalışma bölgede yürütülen nadir Paleolitik arkeoloji araştırmalarından biridir ve Pleistosen Dönem’de yüksek rakımlı bölgelerde insanların yaşayabildiğini, Sivas’ın Pleistosen’de de önemli bir geçiş bölgesi olduğunu, bölgede en azından iki farklı insan türünün yaşamış olması gerektiğini ortaya koymuştur.
TRATAMENTO DE EFLUENTE DE LATICÍNIO POR PROCESSO OXIDATIVO AVANÇADO TIPO FENTON‑FOTOCATALISADO
Authors: da Silva Layanne , Rocha Ana Paula , de Araujo Gilmar , Araujo Thais , de Figueiredo Douglas , Gomes Josivanda
Published: January 2024

TREATMENT DAIRY INDUSTRY WASTE WATER BY ADVANCED OXIDATION PROCESSES PHOTOCATALYSIS-SELF-FENTON SYSTEM. With the increase in industrial production, there is a direct increase in waste generation. Milk processing industries are one of these cases that results in a complex effluent with a high organic load. If the effluent is discarded without proper treatment, it can compromise the survival of biota in water courses. Advanced oxidation processes (AOP) are one of the main technologies used in the treatment of effluents, especially the Photocatalysis-Self-Fenton System (PF) type. The present study aimed to evaluate the efficiency of the PF process and to optimize the parameters of dairy effluent treatment. The raw effluent was characterized considering the parameters: conductivity, pH, chemical oxygen demand (COD), solids, and oils and greases. Through an experimental design, the variation of the concentrations of Fe2+, H2O2 and the reaction time were optimized, and the influence of these three variables on the removal of COD was evaluated. Statistical analysis showed that all variables were statistically significant, and the model used had a coefficient of determination of 0.97, confirming that the model was well adjusted. The ideal conditions for COD removal, reaching 79%, were obtained in 60 min, 0.625 g L-1 of Fe²+ and 0.829 mL L-1 of H2O2.
Alimentación natural del pejerrey (Patagonia hatcheri ) introducido en la laguna Ñe-luan, Rio Negro
Authors: Bello María Teresa , Bunge María Marta , De Lourdes Baiz Miguel
Published: January 2024

Se han analizado 72 tractos digestivos de pejerreyes (Patagonina hatcheri Eigenmann, 1927) capturados en la laguna Ñe-luan (Rio Negro, Argentina), entre septiembre de 1980 y agosto de 1982, con tallas comprendidas entre 96 y 385 mm de longitud total. Cinco categorías de alimento conforman el espectro trófico: macrófitas, microcrustáceos, quironómidos, moluscos y "otros". Se han estimado el porcentaje numérico, el porcentaje volumétrico y la frecuencia de presencia, para calcular el índice de importancia relativa (IRI) de cada alimento en la dieta general y se han discutido sus variaciones estacionales. Estas investigaciones permiten conocer la alimentación natural de P. hatcheri en este ambiente.
FECUNDIDAD DE LA ANCHOITA ENGRAULIS ANCHOITA HUBBS Y MARINI1935 PROVENIENTE DE LA PESCA COSTERA MARPLATENSE EN OCTUBRE DE 1987
Authors: Louge Elena B. , Christiansen Haraldo E.
Published: January 2024

En el presente trabajo se determina la fecundidad de Engraulis anchoita sobre la base de muestras provenientes de la costa marplatense (38°S57°W) obtenidas en octubre de 1987. Se extrajeron las gónadasde 190 hembras fijándolas en formol 10%, luego se incluyeron en parafina y se colorearon con hematoxilina-eosina. Por análisis microscópico se diagnosticó que 23 gónadas se encontraban en maduración total. Con ellas se calculó la fecundidad mediante la técnica estereométrica (Weibel, 1969). La fecundidad parcial promedio fue de 11.040 ovocitos por ejemplar con un rango entre 5.000 y 31.000, y mostrando un ajuste lineal con las siguientes características individuales que en orden decreciente de correlación fueron: Fec./peso gonadal, volumen gonadal, peso total del cuerpo, peso total sin ovario, y talla. La fecundidad relativa media, calculada como el número de ovocitos por gramo de peso total del cuerpo menos el peso del ovario es de 355 ± 190. La fecundidad promedio por cm3 de ovario fue de 3.485 ± 1.267 ovocitos. Este valor no varió en función de la talla ni del peso total del ejemplar, lo cual sugiere la posibilidad de considerarlo como parámetro de fecundidad característico de la especie, pero debido al escaso número de observaciones realizadas, su constancia deberá ser verificada.
Historical landings and management options for the genus Mesodesma in coasts of South America.
Authors: Defeo Omar , De Alava Anita , Valdivieso Violeta , Castilla Juan Carlos
Published: January 2024

This work compiles and updates Information onthedevelopmentofsurf clams'fisheriesof the genus Mesodesma in the coasts of South America. Landings, pnces and exportation valúes (when available), are analyzed for those countries where the species are present: Brazil, Argentine, Uruguay, Perú and Chile. A marked increase in catches during the 80's was observed in Chile, Perú and Uruguay. Argentine maintains a closed season imposed since 1958, while the lack oí available data preclude us to analyze the evolutionof the Brazilian fishery. A lackof regulatory measures, the prevailing open access-system established in four of the five countries analyzed and the marked increase in demand for the produet by domesticand foreign markets, suggest a serious risk of over-exploitation oí the Mesodesma resource. A dissimilar State oí ecological and fishery knowledge observed in the mentioned countries aggravates the above situation. Implications derived from different management scenarios are discussed. Finally, íuture lines of research that ought to be developed in the región are proposed.
La fauna parasitaria y la morfometría de la Merluza Austral Merluccius australis (HUTTON) como indicadores de unidades de stock.
Authors: Nascimento Mario George , Arancibia Hugo
Published: January 2024

Se examinó la fauna parasitaria y la morfometría en 685 ejemplares de la merluza austral Merluccius australis (Hutton) recolectados entre 1992 y 1993 desde aguas interiores y exteriores de la XIa y XII* Regiones de Chile en el Océano Pacífico, (entre 44°S y 56°S) hasta la vecindad de las islas Malvinas, en el Atlántico. A cada ejemplar se le midieron 23 distancias corporales, y se recolectaron 15.339 parásitos de 15 taxa de metazoos. Los análisis estadísticos consideraron técnicas uni y multivariadas. Se encontró una gran similitud parasitaria y morfométrica de la merluza austral entre las zonas de pesca, aunque también hay diferencias menores que son significativas, y que sugieren patrones migracionales y de variaciones de la alimentación y de otras condiciones ecológicas a las que están expuestas las merluzas a lo largo de su vida. Estas diferencias radican principalmente en la composición de tallas de las merluzas según zonas de pesca, y en las diferencias en la magnitud del parasitismo por Elytrophalloides oatesi, Derogenes varicus, Grillotiaheptanchi, Hysterothylacium sp., Clestobothrium crassiceps, Contracaecum sp. y Hepatoxylon trichiuri. Se postula que existe sólo un stock puro y al menos cuatro stocks ecológicos en el área de estudio.
Análisis cualitativo y cuantitativo del semen de Puye Galaxias maculatus (JENYNS, 1842) (SALMONIFORMES: GALAXIIDAE)
Authors: Valdebenito Iván , Bariles Juan , Vega Rolando , Dantagnan Patricio , Bórquez Aliro , Carreño Eriko
Published: January 2024

En la presente investigación se estudió cuali y cuantitativamente el semen del puye (Galaxias maculatus). Para ello se capturaron especímenes adultos (6,24 ± 0,84 cm de longitud estándar) de aguas límnicas del Sur de Chile y luego fueron mantenidos en cautiverio. Una vez maduros, diez especímenes fueron anestesiados y mediante masaje abdominal se les extrajo una muestra de semen que se sometió a examen visual, recuento espermático, espermatocrito y motilidad. Los resultados obtenidos muestran que el semen del puye es poco abundante (máximo 0,2 mi por individuo), de color blanquecino y gran viscosidad. Cuantitativamente se encontró un promedio de 55,3 x 10” espermatozoides/mi, un espermatocrito de 89,63 % y una correlación entre ambas variables de r=0,97. La motilidad frente a distintos activadores es muy baja y sólo se observó una motilidad igual a 2 (en una escala de 0 a 5) por aproximadamente 30 min al utilizar un activador en base a carbamida.
Recent Approaches on Molecular Markers, Treatment and Novel Drug
Delivery System Used for the Management of Colorectal Cancer:
A Comprehensive Review
Authors: Chauhan Sonia , Sharma Sakshi
Published: January 2024

:

Colorectal cancer affects 1 in 25 females and 1 in 24 males, making it the third
most frequent cancer with over 6,08,030 deaths worldwide, despite advancements in detection
and treatments, including surgery, chemotherapeutics, radiotherapy, and immune therapeutics.
Novel potential agents have increased survival in acute and chronic disease conditions, with a
higher risk of side effects and cost. However, metastatic disease has an insignificant long-term
diagnosis, and significant challenges remain due to last-stage diagnosis and treatment failure.
Early detection, survival, and treatment efficacy are all improved by biomarkers. The advancement
of cancer biomarkers' molecular pathology and genomics during the last three decades
has improved therapy. Clinically useful prognostic biomarkers assist clinical judgment,
for example, by predicting the success of EGFR-inhibiting antibodies in the presence of
KRAS gene mutations. Few biomarkers are currently used in clinical settings, so further research
is still needed. Nanocarriers, with materials like Carbon nanotubes and gold nanoparticles,
provide targeted CRC drug delivery and diagnostics. Light-responsive drugs with gold
and silica nanoparticles effectively target and destroy CRC cells. We evaluate the potential use
of the long non-coding RNA (non-coding RNA) oncogene plasmacytoma variant translocation
1 (PVT1) as a diagnostic, prognostic, and therapeutic biomarker, along with the latest nanotech
breakthroughs in CRC diagnosis and treatment.
Efficacy and Safety of Phosphatidylinositol 3-kinase Inhibitors for
Patients with Breast Cancer: A Systematic Review and Meta-analysis of
Randomized Controlled Trials
Authors: Wang Yi , Du Xianling , Xin Hongqiang , Xu Ruimin
Published: January 2024

Background::

Phosphatidylinositol 3-kinase (PI3K) inhibitors belong to the class of
drugs that inhibit the activity of the PI3K protein, which is commonly overexpressed in breast cancer
cells. However, there is a need to summarize the evidence to provide conclusive advice on the
benefit of PI3K inhibitors in breast cancer patients. Therefore, this review assessed the effectiveness
and safety of the PI3K inhibitors amongst breast cancer patients.

Methods::

Searches were made in PubMed Central, EMBASE, MEDLINE, SCOPUS, CENTRAL,
WHO trial registry and Clinicaltrials.gov up to December 2022. Meta-analysis was executed using
the random-effects model. Pooled hazard ratio (HR)/risk ratio (RR) was reported with 95% confidence
intervals (CIs).

Results::

In total, 13 studies were included in the analysis. Most were multi-country studies and
had a higher risk of bias. Regarding the efficacy parameters, pooled HR for progression-free survival
was 0.79 (95%CI: 0.67-0.92), pooled RR for complete response was 1.54 [95%CI: 1.14 to
2.09], partial response was 1.18 [95%CI: 0.87-1.61], overall response was 1.20 [95%CI:
0.93-1.56], stable disease was 1.09 [95%CI: 0.78-1.53], progressive disease was 0.80 [95%CI:
0.74 to 0.87], and clinical benefit was 1.08 [95%CI: 0.80-1.49]. For safety parameters, pooled RR
for hyperglycemia was 4.57 [95%CI: 3.15-6.62], and gastrointestinal toxicity was 1.82 [95%CI:
1.56 to 2.14].

Conclusion::

PI3K inhibitors had better efficacy than the present standard of concern for patients
with breast cancer, especially among patients with PIK3CA mutations. Hence, clinicians and oncologists
can provide this drug for the target population with extra caution for diabetes patients.
Schiff Bases: Versatile Mediators of Medicinal and Multifunctional
Advancements
Authors: Biswas Tanya , Mittal Ravi K. , Sharma Vikram , Kanupriya  , Mishra Isha
Published: January 2024

This review aims to shed light on the profound implications of Schiff Bases in combating a
spectrum of pathogens by delving into their complex classification, synthesis, and reactions. The investigation
also covers the varied molecular properties of Schiff bases, highlighting their potential
use as chelating agents in coordination chemistry. Moreover, the investigation explores the discerning
nature of Schiff Bases about metal ions and their adeptness in establishing intricate associations,
highlighting their significance in metal coordination chemistry and specialized pharmaceutical
transport mechanisms. Moreover, the review delves into the synthetic capacity of Schiff Bases, highlighting
their importance in synthetic methodologies due to their exceptional adaptability, selectivity,
and structural similarity to organic compounds. The methodology employs a rigorous systematic literature
review to understand Schiff Bases comprehensively. This involves a meticulous analysis of
various research articles and publications, allowing for a comprehensive exploration of the topic. The
assessment of experimental investigations contributes to comprehending their molecular attributes,
specificity for metal ions, and capacity for synthesis. The presented analysis amalgamates a multitude
of sources to provide a nuanced and comprehensive viewpoint on the subject matter of Schiff Bases.
The findings underscore the multifaceted utility of Schiff Bases in the fight against pathogens, their
adaptability as chelating compounds, and their discerning affinity for metal ions. The examination of
synthesis highlights their profound importance in synthetic methodologies and their striking resemblance
to compounds found in living organisms. In conclusion, this analysis reveals Schiff Bases as
highly adaptable compounds with potential in antimicrobial therapy, coordination chemistry, and
precision drug delivery. The distinctive molecular attributes of these substances, functioning as chelators,
contribute to their notable importance. The ability of Schiff bases to form complexes and their
preference for metal ions highlight the wide range of applications for these molecules. Schiff Bases
have a transformative effect on chemistry and medicine as we investigate their synthetic potential,
driven by their versatility and structural similarity to biological compounds.
Emerging Phytochemicals to Treat Leishmaniasis: A Review of
Experimental Studies from 2011 to 2021
Authors: Namdeo Madhulika , Veronica Jalaja , Kumar Krishan , Anand Anjali , Maurya Radheshyam
Published: January 2024

:

Leishmaniasis is a protozoan disease caused by a parasite from the genus Leishmania.
It is known as a neglected tropical disease by WHO and is the second-leading cause of death by
parasites after malaria. Chemotherapy is the only effective way to control the disease, but
treatment options for leishmaniasis are limited. The majority of the drugs are costly, have serious
side effects and necessitate hospitalisation. The lack of an effective vaccine, in addition to the
emergence of resistance to currently available drugs, has all been raised as major concerns,
especially in endemic areas of developing countries. Phytochemicals might contribute to the
development of novel and effective drugs for the treatment of leishmaniasis by providing
selectively targeted intervention in parasites. Many phytochemicals (quinones, alkaloids,
terpenes, saponins, phenolics) and their derivatives are quite active against diverse groups of
pathogens, such as viruses, bacteria, fungi and parasites. To date, many phytochemicals have
shown potent anti-leishmanial activity with highly selective mode of action. However, due to a
lack of interaction between academician and pharma industries none of them has undergone the
clinical assessment. The present review will analyse the most promising phytochemicals and their
synthetic compounds, which have shown antileishmal activity in in-vitro and subsequently in
animal studies from 2011-2021. These phytochemicals are apigenin, hydroxyflavanone,
Epigallocatechin-O-3 gallate, caffeic acid, α-bisabolol, β-caryophyllene, ursolic acid, quinones,
which have shown notable anti-leishmanial activities in several independent studies.
Natural Alkaloids and Mechanisms for Anti-cancer Action: A Review
Authors: Mishra Prem Shankar , Kaushik Niranjan , Mishra Rakhi , Koul Sameeksha , Sagar Sakshi
Published: January 2024

:

Cancer is a global public health issue. Cancer therapy has been hampered by the issue
of multidrug resistance, which is one of the leading causes of death worldwide. As a result, the
use of natural derived drugs for cancer prevention and therapy has been researched and developed
for decades. Alkaloids are plant-derived secondary metabolites that have antiproliferative and
anticancer effects on several forms of cancer. Camptothecin and vinblastine, two anticancer medicines
derived from alkaloids, have been adequately developed in the past. Alkaloids, a drug lead
compounds, derived from natural products, have the advantage of being used by the host, making
them suitable for further exploitation. The current review looks at the anticancer potential of numerous
naturally occurring alkaloids, as well as the mechanism behind their anticancer effect.
Pt(IV) Complexes with Biologically Active and Physicochemical Properties
Modifier Ligands
Authors: Aher Sainath , Zhu Jinhua , Liu Xiuhua , Borse Laxmikant
Published: January 2024

:

The octahedral Pt(IV) complexes contain either inert or biologically active ligands
where the nature of these axial ligands provides additional stability and synergistic biological activity.
There are many literature reports from each of the classes mentioning the varied nature of
these axial ligands. The targeting, as well as the non-targeting nature of these moieties, exerts
additive or synergistic effects of anticancer activity of Pt(II) moieties. Herein, we have discussed
the effects of these axially oriented ligands, changes in the non-leaving am(m)ine groups, and
changes in the leaving groups on the biological activity. In this review, we have discussed the
axial ligands with a focus on the nature of the ligands and alterations in biological activities.
The Role of Long Noncoding RNAs in Progression of Leukemia: Based on
Chromosomal Location
Authors: Sabaghi Fatemeh , Sadat Saina Yousefi , Mirsaeedi Zohreh , Salahi Aref , Vazifehshenas Sara , Kesh Neda Zahmat , Balavar Mahdieh , Ghoraeian Pegah
Published: January 2024

Long non-coding RNA [LncRNA] dysregulation has been seen in many human cancers, including several kinds of leukemia, which is still a fatal disease with a poor prognosis. LncRNAs have been demonstrated to function as tumor suppressors or oncogenes in leukemia. This study covers current research findings on the role of lncRNAs in the prognosis and diagnosis of leuke-mia. Based on recent results, several lncRNAs are emerging as biomarkers for the prognosis, di-agnosis, and even treatment outcome prediction of leukemia and have been shown to play critical roles in controlling leukemia cell activities, such as proliferation, cell death, metastasis, and drug resistance. As a result, lncRNA profiles may have superior predictive and diagnostic potential in leukemia. Accordingly, this review concentrates on the significance of lncRNAs in leukemia pro-gression based on their chromosomal position.
Glucose-Water Synergy: An Organocatalytic System Driven synthesis of
Benzimidazolo[2,3-b]quinazolinone and Benzothiazolo[2,3-b]quinazolinone
Derivatives
Authors: Baranwal Jyoti , Singh Swastika , Kushwaha Smriti , Jyoti Archana
Published: January 2024

Introduction:

A simple and efficient one-pot synthesis of quinazolinone derivatives has
been developed via a multicomponent reaction (MCR) involving the condensation of dimedone,
benzaldehyde, and 2-aminobenzimidazole/2-aminobenzothiazole.

Method:

In this work, glucose water is used as a green, reusable, environmentally benign organocatalytic
solvent system to synthesize desired products.

Result:

The main benefits of this one-pot method include its excellent yields, less time, cost-effectiveness,
atom economy, environment benign, and easy workup.

Conclusion:

In conclusion, we successfully developed a green protocol for the environmentally
benign synthesis of benzimidazo/benzothiazolo quinazolinones using glucose water as an organocatalytic
medium.
Benefits of Medicinal Plants in Boosting Immunity against Viral Infections Including COVID-19
Authors: Prajapati Uday Bhan , Srivastav Arun Lal , Grewal Ajmer Singh
Published: January 2024

Background: Medicinal plants can be beneficial for boosting immunity against viral
infections by inducing immune functions, antiviral activity, and immunomodulatory effects, and
serving as potential alternative therapies. These benefits make them an important resource for
managing viral diseases, including COVID-19. Millions of people in more than 200 countries are
faced with health emergencies because of this viral disease. However, some allopathic medicines
are being used to moderate the negative health impacts of coronavirus on human beings. Although
many therapeutic drug candidates have reached phase 3 trials, due to a lack of sufficient
clinical data and large randomized trials, none has been approved yet.

Methods: We have employed databases, like Google Scholar, Research Gate, Scopus, PubMed,
Web of Science, etc., for the literature review using keywords, like medicinal plants, antiviral
activity, COVID-19, etc. Medicinal properties of some plants have been considered in the present
study, especially those possessing anti-viral properties. Also, the antiviral potential of some
phytoconstituents against COVID-19 has also been discussed.

Results: In the present article, therapeutic properties of numerous plants [e.g., Ocimum sanctum
L. (Tulsi), Vitex trifolia L. (Nirgundi), Crocus sativus L. (Saffron or Kesar), etc.] have been
thoroughly discussed against viral infections, including COVID-19. Several medicinal plants
have been reported to exert immunomodulatory effects, which can help regulate the immune system
and improve its response to viral infections. They can be used as a primary preventive
measure during home quarantine to improve immunity and provide protection against viral infections.
A strong immune system can help protect against infections, provide faster recovery
from infections, prevent chronic diseases, and improve overall health and well-being.

Conclusion: This review article might be valuable for conducting future research for developing
medicines against infectious diseases, like COVID-19. Medicinal plants could be useful for the
pharmaceutical industries to minimize the impact of various viral infections, such as COVID-19.
Hydrogel for the Treatment of Diabetic Wounds: A Comprehensive Review
Authors: Bhattacharyya Soubhik , Sarkar Dhrubajyoti , Bora Devanjal , Gautam Manish Kumar
Published: January 2024

The management of chronic wounds in diabetic patients is a tough challenge, compounded by elevated amputation rates, frequent recurrence, and increased mortality rates. Nonhealing wounds in people with diabetes are produced by a combination of variables that impede
the clearance of injured tissue, stimulate the formation of healthy cell populations, and increase
the risk of infection. Traditional wound dressings, such as gauze, films, and bandages, focused
solely on hydration and infection prev ention. However, recent scientific investigation has shifted toward advancements in wound healing treatments to overcome the constraints inherent in old
methodologies. Hydrogel dressings have surfaced as a particularly enticing and promising avenue for increasing wound healing prowess in the modern medical environment, owing to their
remarkable ability for moisture retention, biocompatibility profiles, and therapeutic attributes.
The pathophysiology of diabetes wounds has been better studied in recent decades, and a range
of functionalized hydrogel dressings have been reported with favourable outcomes, indicating
that they have significant potential in healing diabetic wounds. Our approach will comprise a
systematic and comprehensive evaluation of the advancements in hydrogel dressing methods
related to diabetic wounds. This review presents a strong theoretical foundation for advancing
hydrogel dressing technologies and offers suggestions for treating diabetic wound-related problems.
Insights into Prospects of Novel NSAID Prodrugs in the Management of
Gastrointestinal Toxicity: A Perspective Review
Authors: Goyal Rajat , Gupta Sumeet , Sharma Prabodh , Sharma Manu
Published: January 2024

Non-steroidal anti-inflammatory drugs (NSAIDs) have a long history in the
healthcare system due to their therapeutic potential. These NSAIDs cause ulcerogenicity, stomach
pains, gastrointestinal hemorrhage, mucosa bleeding, and pancreatitis when used moderately
and consistently. With researchers, managing the aforementioned adverse effects therapeutically
is getting increasingly difficult. One method for creating NSAID moieties with low penetration
as well as ulcerogenic properties is the prodrug technique. During the oral consumption
of NSAID-prodrugs, ulcerations, intestinal hemorrhage, and mucosa hemorrhage have significantly
decreased. Considering this background, this review focussed on NSAID prodrugs as
well as their justifications, the pathogenesis of NSAIDs inducing gastrointestinal toxicity, and
the role of different antioxidants and spacer groups. Prodrug moieties have more advantages
over parent medicines concerning both solubility and lipophilicity. In general, NSAID-class
prodrugs can successfully treat both acute and long-term inflammation and aches without causing
ulcerotoxicity and related gastrointestinal side effects, which reduces their burden from the
pharmacoeconomic perspective.
Tecnologias de Informação e Comunicação, Ativismo e Movimentos Sociais
Authors: Ruskowski Bianca de Oliveira , Da Silva Camila Farias , Fernandes Eduardo Georjão , Da Silva Marcelo Kunrath , Pereira Matheus Mazzilli
Published: January 2024

Significativas mudanças nos processos de organização e/ou mobilização social contestatória relacionadas à incorporação das Tecnologias de Informação e Comunicação (TICs) ocorreram na última década, fomentando esforços de pesquisa para a identificação e análise dessas mudanças. O objetivo deste artigo é analisar a literatura brasileira que aborda o tema das TICs a partir da perspectiva do campo de estudos de movimentos sociais. Para responder a esse objetivo, foi realizada uma análise sistemática da literatura acadêmica brasileira recente (2010-2017). Tal análise identifica diversas lacunas e fragilidades na literatura, destacando-se uma significativa desconsideração dessa literatura em relação ao conhecimento acumulado pelo campo de estudos de movimentos sociais. Conclui-se o artigo com algumas sugestões no sentido de enfrentar aquela desarticulação e avançar na construção de um campo estruturado de pesquisa empírica e formulação teórica sobre as relações entre TICs e processos de organização e/ou mobilização social contestatória no Brasil.
Mídia, saúde e discurso
Authors: Baesso Marise
Published: January 2024

Entrevista com o professor Wedencley Alves
Vejo, mas não acredito
Authors: Azevedo Dilvan
Published: January 2024

As pessoas, de um modo geral, acreditam na capacidade da mídia de influenciar os outros. Mais ainda, elas também acreditam em sua própria capacidade de avaliar o tipo e o grau dessa influência e podem agir em função disso – fenômeno conhecido com Efeito de Terceira Pessoa (ETP). Como, então, as pessoas costumam avaliar a influência de conteúdos midiáticos sobre a decisão de voto dos outros? O propósito deste estudo, portanto, é examinar alguns pressupostos da hipótese do ETP a partir da percepção dos indivíduos acerca do grau de influência de quatro tipos de conteúdo (notícias, debates, pesquisas de opinião e, sobretudo, conteúdos do WhatsApp) sobre a sua decisão de voto e sobre a decisão de voto dos outros, durante a campanha presidencial brasileira de 2018. Os dados para a pesquisa foram coletados por meio de questionário online divulgado entre grupos de WhatsApp, logo após o primeiro turno, e contou com a participação de 155 pessoas. Os resultados confirmaram as principais hipóteses relacionadas ao ETP, sobretudo no que diz respeito aos conteúdos que circularam no WhatsApp.
Apresentação
Authors: Chagas Viktor , Cervi Emerson Urizzi , Mendonça Ricardo Fabrino
Published: January 2024

Editorial da edição 2021.1.
Do discurso político ao discurso jornalístico
Authors: Vicenzi Liziane Nathália , Bertasso Daiane
Published: January 2024

Este artigo reflete a respeito da conjuntura política brasileira no governo do ex-presidente do Brasil Michel Temer, decorrente do processo de impeachment da então presidente Dilma Rousseff. O objeto de estudo é a construção da imagem de si (ethos discursivo) nos pronunciamentos de Michel Temer e a produção de sentidos realizada pelos portais jornalísticos G1/O Globo e Uol/Folha de S. Paulo a respeito de tais pronunciamentos. O objetivo geral é compreender as possíveis mudanças desse discurso político para o discurso jornalístico. A análise discursiva possibilitou identificar semelhanças nos sentidos das formações discursivas da imagem de si de Temer com as formações discursivas dos portais, demonstrando falta de criticidade na abordagem jornalística. Destaca-se ser preocupante o impacto que essas relações discursivas e de poder podem trazer, em médio e longo prazo, para a democracia no país.
Apresentação
Authors: Carvalho Fernanda Cavassana de , Mendonça Ricardo Fabrino
Published: January 2024

Editorial 2021.2
Com o que se gasta ao fazer campanha nas capitais brasileiras?
Authors: Verner Afonso Ferreira
Published: January 2024

As eleições municipais brasileiras de 2020 foram realizadas em meio a pandemia da Covid-19 e essa circunstância fez com que uma série de mudanças fossem impostas na forma de fazer campanha, inclusive com adiamento do calendário eleitoral. O objetivo deste artigo é compreender padrões nos tipos de gastos de campanha declarados por candidatos(as) que disputaram o comando das 26 capitais brasileiras em 2020. A pergunta que move esse artigo é: há diferenças nos gastos que tipos de candidatos fazem durante a campanha? A pesquisa lança mão de uma metodologia quantitativa e reúne dados das prestações de contas de todos(as) os(as) candidatos(as) de capitais que tiveram as candidaturas deferidas, formando um corpus de 304 candidatos(as). Os dados apontam para a manutenção de mecanismos de campanha off-line. Desta forma, a pesquisa conclui que há um padrão nas campanhas em capitais brasileiras representado pelo gasto com mecanismos tradicionais (rádio, TV e material impresso), enquanto os gastos com ferramentas de campanha on-line representaram fatias pequenas dos gastos das disputas.
Reconhecimento e deliberação no encontro com Fátima Bernardes
Authors: De Macêdo Raíssa Sales
Published: January 2024

O artigo analisa a abordagem de temáticas relacionadas à teoria do reconhecimento no âmbito da mídia, além de averiguar a possibilidade de, a partir de tais discussões, serem desencadeadas trocas comunicativas mais plurais. Para isso, realiza-se uma análise de conteúdo de três edições especiais do programa Encontro com Fátima Bernardes. Os resultados constatam a ausência de elementos deliberativos durante as discussões, ao passo que se observam discursos sobre diversas formas de reconhecimento, sobretudo envolvendo questões de estima social e exclusão. Conclui-se, então, que, embora o programa não promova efetivamente momentos de deliberação, ele proporciona reflexões acerca do reconhecimento de minorias sociais que podem fomentar a tolerância e aumentar a qualidade das deliberações públicas.
Entre o antipetismo e a terceira via
Authors: Alves Mércia , Martins Joyce Miranda Leão
Published: January 2024

O Horário Gratuito de Propaganda Eleitoral (HGPE) é uma das variáveis explicativas do voto no Brasil. Em 2018, a campanha na TV teve a duração reduzida e passou a coexistir com outros espaços de comunicação. Nesse contexto, o objetivo do artigo é verificar as estratégias discursivas mobilizadas por Geraldo Alckmin para se colocar como alternativa viável às candidaturas de PSL e PT, que lideraram a corrida presidencial no primeiro turno.  O corpus empírico são os programas do HGPE e os spots do candidato à Presidência da República pelo PSDB. O método utilizado é a Análise do Discurso. Argumentamos que, em um ambiente com grande polarização, a imagem de uma oposição moderada foi rejeitada. Foram dois os sentidos mobilizados na construção do ethos de Alckmin: de melhor opção ao antipetismo à “terceira via” entre as candidaturas de Haddad e Bolsonaro. Posteriormente, rende-se ao "antipetismo emocional" e afirma que só o PSDB venceria o PT no segundo turno.
Personalização e positividade dos candidatos a prefeito
Authors: Costa Leonardo Roque , Rodrigues Lucena Tiago Franklin , Nascimento Rossetto Graça Penha
Published: January 2024

Esta pesquisa apresenta uma análise de conteúdo das postagens na rede social Instagram feitas pelos candidatos a prefeito de Maringá (PR) durante o período de campanha eleitoral de 2020. Observamos que os candidatos produziram mais stories do que posts no feed. Os vídeos foram menos frequentes que as imagens e, entre as imagens, os candidatos postaram mais fotografias do que cards. Nos posts no feed foram identificadas e criadas nove categorias temáticas: Agenda, Imagem Pessoal, Propostas, Valores, Críticas, Datas Especiais, Informativos e Outros. A rede foi usada principalmente como espaço para divulgação de propostas e informações. Salvaguardadas as exceções, os candidatos usaram o Instagram com foco na sua apresentação de forma positiva.
De guardião da democracia a inimigo da liberdade do povo:
Authors: Cardoso Laís Cristine Ferreira , Da Rocha Heitor Costa Lima
Published: January 2024

O presente artigo analisa a imagem pública do Tribunal Superior Eleitoral (TSE) elaborada nas matérias sobre o voto impresso veiculadas pelo site Terça Livre, que se intitula como jornalismo conservador. Para tal, empreende discursões teóricas sobre mídia e política, a partir de autores como Miguel (2008), Souza (1988), Lycarião, Magalhães e Albuquerque (2018), entre outros; e sobre imagem pública na mídia, sob a ótica de estudos de Noleto Filho (2014) e Gomes (2004). Com aporte metodológico da Análise de Conteúdo de Bardin (2002) numa perspectiva qualitativa, a investigação identificou na imagem pública do TSE construída pelo site Terça Livre um caráter negativo, por caracterizar o tribunal como instituição considerada ineficiente, inimiga da democracia e contrária a liberdade de voto da população.
White Girls in the Apocalypse: Race, Gender, and Sexuality at the End of the World
Authors: Austin Sara
Published: January 2024

The post-apocalyptic white girl savior is merely one installment in a long line of young adult tropes for female characters. Popular media in the post-apocalyptic girl savior subgenre include novels and media adaptations of The Hunger Games (2008; 2012), and The Red Queen (2015), and television series Buffy the Vampire Slayer (1997), Once Upon a Time (2011), Van Helsing (2016), Wynonna Earp (2016), and The Chilling Adventures of Sabrina (2018). Critical discussions of whiteness in film, television, and literature independently draw attention to how each of these forms constructs race and cultural belonging. In this article, I draw from all three formats in order to interrogate formations of whiteness specific to teen and young adult women. Valerie Babb comments that “because it is a created identity, whiteness is sustained through hegemony, a complex network of cultural creations, including among other things, literature, museums, popular music, and movies” (Babb 4-5). Building on Babb’s assertion of the omnipresence of whiteness in culture, the cross-media scope of this project shows the consistency of racial assumptions across platforms. This discussion of white girl saviors is particularly important since these stories are often left out of critical discussions of the White Savior trope. The white girl saviors in these stories often win at the expense of people of color, reifying whiteness, and specifically white reproductive femininity as the anchor of moral right and cultural progress. I identify six common traits that the post-apocalyptic girl savior subgenre uses to substantiate its heroines’ whiteness as a central and natural aspect of heroism including: belonging to the lower socio-economic class, being the chosen one, being uncomfortable with her symbolic role, being at the center of a love triangle, caring for a child, and being a tragic figure. These traits reflect larger patterns that scholars such as Richard Dyer explicitly link to the cultural naturalization of whiteness and power, and I argue, establish certain cultural expectations for teen activists that ignore the historical patterns of activism and may create hostility toward, or even foreclose opportunities for, activists who do not meet these requirements.