bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Digital Economy on the Economic Growth and the Development Strategies in the post-COVID-19 Era: Evidence From Countries Along the “Belt and Road”
Authors: Zhang Jinzhu , Zhao Wenqi , Cheng Baodong , Li Aixin , Wang Yanzhuo , Yang Ning , Tian Yuan
Published: May 2022

The digital economy is considered as an effective measure to mitigate the negative economic impact of the Corona Virus Disease 2019 (COVID-19) epidemic. However, few studies evaluated the role of digital economy on the economic growth of countries along the “Belt and Road” and the impact of COVID-19 on their digital industries. This study constructed a comprehensive evaluation index system and applied a panel data regression model to empirically analyze the impact of digital economy on the economic growth of countries along the “Belt and Road” before COVID-19. Then, a Global Trade Analysis Project (GTAP) model was used to examine the impact of COVID-19 on their digital industries and trade pattern. Our results show that although there is an obvious regional imbalance in the digital economy development in countries along the “Belt and Road”, the digital economy has a significantly positive effect on their economic growth. The main impact mechanism is through promoting industrial structure upgrading, the total employment and restructuring of employment. Furthermore, COVID-19 has generally boosted the demand for the digital industries, and the impact from the demand side is much larger than that from the supply side. Specifically, the digital industries in Armenia, Israel, Latvia and Estonia have shown great growth potential during the epidemic. On the contrast, COVID-19 has brought adverse impacts to the digital industries in Ukraine, Egypt, Turkey, and the Philippines. The development strategies are proposed to bridge the “digital divide” of countries along the “Belt and Road,” and to strengthen the driving effect of the digital economy on industrial upgrading, employment and trade in the post-COVID-19 era.
Dynamic Conservation in Risk Society: A Case Study of COVID-19 Pandemic Risk in Kashan Qanat Irrigated Agriculture
Authors: Manian Mohammad ali , Khoshbakht Korous , Mahmoudi Hossein , Liaghati Houman
Published: May 2022

In the present age, the world agricultural heritage can inspire agroecology and sustainable agriculture. But various risks have threatened, eroded and forgotten this heritage, so dynamic conservation of this heritage is essential. In this study, “Qanat Irrigated Agricultural Heritage Systems, Kashan, Iran” which has been registered worldwide in the face of corona pandemic risks has been selected as a case study. In this qualitative research, in addition to field observations and documentary studies, 25 in-depth interviews and 39 semi-structured interviews with experts and key informants was done and grounded theory and content analysis have been used. In the process of interviews and analyzes based on “risk society theory”, risks and wicked problems and related solutions have been identified and finally based on cultural theory, “clumsy solution space” has been summarized and presented for dynamic conservation. Based on the findings of this study, paying attention to a kind of reward for ecosystem services, developing online sales of agricultural products in rural areas of Kashan and also creating twinning with similar areas can help solve wicked problems. Also, paying more attention to the regulations for the protection of qanats, as well as the laws for home business insurance, can strengthen sustainable development in this rural area. Due to the wide range of different dimensions of agricultural heritage, it is suggested that in future research, clumsy solution spaces for each of these dimensions be created and developed separately.
Brief Research Report: “Nothing About Us, Without Us”: A Case Study of the Outer Sanctum Podcast and Trends in Australian Independent Media to Drive Intersectional Representation
Authors: Symons Kasey , Duncan Sam , Sherry Emma
Published: May 2022

Alternative and independent sports media platforms create custom content that reflects a diversity of voices and representation of athletes, sports and issues that are not covered in meaningful ways in traditional sports media. While these new media outlets often set out to redress the lack of diversity and intersectional approaches to traditional sports media, they are also seeking ways to drive even more change. This in an interesting and important movement to interrogate as these platforms are not only predominantly unfunded, passion projects created by those marginalized groups. This brief research report provides a case study into this emerging alternative media space and its impact in driving change in an ever-evolving sports media landscape. We also discuss the problematic nature of intersectional-redressing work falling on those who still occupy the margins. This report uses a case study of an independent Australian rules football platform, The Outer Sanctum podcast, to focus on these key areas. The case study investigates how this outlet has worked to increase the visibility and profile of marginalized and underrepresented voices discussing football in new ways. It follows their journey as they have taken steps to improve their own diversity, enacting their mantra “nothing about us, without us,” and proactively becoming more intersectional in their content producing journey. This research report will present key findings from the work of this media outlet to drive change and point to the learnings mainstream media can adopt to meaningfully embed intersectional approaches to sports media as core business.
Partial Fibular Head Osteotomy is an Alternative Option in Treatment of Posterolateral Tibial Plateau Fractures: A Retrospective Analysis
Authors: Lu Yao , Wang Gen , Ren Cheng , Xu Yibo , Huang Qiang , Fan Shan , Li Ming , Zhang Kun , Li Zhong , Wang Qian , Ma Teng
Published: May 2022

Objective

This study aimed to evaluate the short-term effects of partial fibular head osteotomy for treating posterolateral tibial plateau fractures.

Methods

A retrospective analysis was performed on 25 patients with posterolateral tibial plateau fractures who were treated using a partial fibular head osteotomy approach. Computed tomography was performed for fracture typing and evaluation. The mode of injury, time from injury to surgery, time for fracture union, range of motion of the knee, and complications were recorded. Knee joint function was evaluated using the Hospital for Special Surgery Mayo Score (HSS).

Results

The mean follow-up period was 21.5 (range, 12–36) months. Fracture united in all patients and the average clinical healing time for fractures was 11.2 ± 1.9 (range, 8–16) weeks. The mean time from injury to surgery was 3.1 ± 1.8 (range, 1–10) days. The mean range of flexion was 131.6° ± 12.5° (range, 110°–145°). The mean range of extension was 1.4°–4.2° (range, −5°–10°). The mean HSS at the final follow-up was 93.5 ± 5.4 (range, 79–100). None of the patients exhibited symptoms of common peroneal nerve injury, knee instability, or upper tibiofibular joint injury. One patient had a superficial infection and was treated with surgical dressing.

Conclusion

The partial fibular head osteotomy approach is a feasible alternative for treating posterolateral tibial plateau fractures.
Methodology for Determining Phthalate Residues by Ultrasound–Vortex-Assisted Dispersive Liquid–Liquid Microextraction and GC-IT/MS in Hot Drink Samples by Vending Machines
Authors: Ianiri Giuseppe , Di Fiore Cristina , Passarella Sergio , Notardonato Ivan , Iannone Alessia , Carriera Fabiana , Stillittano Virgilio , De Felice Vincenzo , Russo Mario Vincenzo , Avino Pasquale
Published: May 2022

In this study, a simple, fast, and effective methodology has been developed for the detection and quantification of seven phthalates potentially released in hot drinks from disposable containers used in vending machines. The authors determined the optimal conditions to be applied during the various steps of extraction of seven phthalates (DMP, DEP, DBP, DiBP, DEHP, DNOP, and DDP) from hot beverages using a model solution. The extraction and preconcentration technique used was ultrasound–vortex-assisted dispersive liquid–liquid microextraction (UVA-DLLME) followed by gas chromatographic analysis obtaining recoveries from 66.7% to 101.2% with precision and reproducibility <6.3% and <11.1%, respectively. The influence of waiting time, from the dispensing of the drink to its actual consumption, for the extraction of molecules was investigated, obtaining a temporal release profile slightly shifted towards the PAEs with higher molecular weight and vice versa for those with low molecular weight. In addition, the best instrumental parameters to be applied during the analysis of the extracts obtained were established. This optimization was carried out using GC-FID, whereas the analysis of real samples was carried out by means of GC-IT/MS for ultra-trace analysis purposes; limits of detection (LODs) ranging between 0.8 ng mL−1 and 15.4 ng mL−1 and limits of quantification (LOQs) from 1.6 ng mL−1 to 35.8 ng mL−1, both of them lower than those found by FID, were obtained.
IFNγ-Treated Macrophages Induce EMT through the WNT Pathway: Relevance in Crohn’s Disease
Authors: Macias-Ceja Dulce C. , Coll Sandra , Bauset Cristina , Seco-Cervera Marta , Gisbert-Ferrándiz Laura , Navarro Francisco , Cosin-Roger Jesus , Calatayud Sara , Barrachina María D. , Ortiz-Masia Dolores
Published: May 2022

Background: Fibrosis is a common complication of Crohn’s disease (CD) in which macrophages play a central role. Epithelial-mesenchymal transition (EMT) and the WNT pathway have been associated with fibrosis. We aim to analyse the relevance of the tissue microenvironment in macrophage phenotype and the EMT process. Methods: Intestinal surgical resections are obtained from control and CD patients with stenotic or penetrating behaviour. Cytokine’s expression, macrophage phenotype, EMT markers and WNT signalling pathway are determined by WB, RT-PCR, ELISA or Cytometry. U937 cells are treated with IFNγ, TNFα, IL1β, IL4 or IL10 and co-cultured with HT29 cells and, in some cases, are treated with XAV939 or miFZD4. The expression of macrophage, EMT and WNT pathway markers in U937 or HT29 cells is analysed by WB or RT-PCR. Results: IFNγ, WNT6, CD16 and CD86 are increased in the intestinal tissue of CD patients. IFNγ-treated U937 activated the EMT process and WNT pathway in HT29 cells, and the EMT process is mediated by FZD4. Conclusions: An IFNγ-rich microenvironment polarises macrophages, which induces EMT through the WNT pathway.
Natural Polymers in Heart Valve Tissue Engineering: Strategies, Advances and Challenges
Authors: Ciolacu Diana Elena , Nicu Raluca , Ciolacu Florin
Published: May 2022

In the history of biomedicine and biomedical devices, heart valve manufacturing techniques have undergone a spectacular evolution. However, important limitations in the development and use of these devices are known and heart valve tissue engineering has proven to be the solution to the problems faced by mechanical and prosthetic valves. The new generation of heart valves developed by tissue engineering has the ability to repair, reshape and regenerate cardiac tissue. Achieving a sustainable and functional tissue-engineered heart valve (TEHV) requires deep understanding of the complex interactions that occur among valve cells, the extracellular matrix (ECM) and the mechanical environment. Starting from this idea, the review presents a comprehensive overview related not only to the structural components of the heart valve, such as cells sources, potential materials and scaffolds fabrication, but also to the advances in the development of heart valve replacements. The focus of the review is on the recent achievements concerning the utilization of natural polymers (polysaccharides and proteins) in TEHV; thus, their extensive presentation is provided. In addition, the technological progresses in heart valve tissue engineering (HVTE) are shown, with several inherent challenges and limitations. The available strategies to design, validate and remodel heart valves are discussed in depth by a comparative analysis of in vitro, in vivo (pre-clinical models) and in situ (clinical translation) tissue engineering studies.
Effect of Culturally Adapted Dental Visual Aids on Oral Hygiene Status during Dental Visits in Children with Autism Spectrum Disorder: A Randomized Clinical Trial
Authors: Aljubour Ala , AbdElBaki Medhat , El Meligy Omar , Al Jabri Basma , Sabbagh Heba
Published: May 2022

Autism spectrum disorder (ASD) prevalence has escalated in the last few decades; it is common to have children with ASD seek dental treatment. Their unique behavior patterns prevent them from attending a regular dental setting and receiving proper oral hygiene instructions (OHI); therefore, culturally adapted dental visual aids are necessary to teach them proper OHI. The aim of this study was to assess the effectiveness of culturally adapted dental visual aids in improving oral hygiene (OH) status in children with ASD. A blinded, randomized, controlled clinical trial with sixty-four children with ASD were randomly divided into two groups according to the type of dental visual aids given to them. The experimental group received culturally adapted dental visual aids developed specifically for the study, and the control group received regular dental visual aids. OH status was assessed before and after using the dental visual aids, and data were processed using SPSS version 25.0. OH status improved significantly in both groups after using the dental visual aids (p < 0.001, p < 0.001), respectively. The experimental group showed significant improvement in comparison to the control group in OH status (p = 0.030). Both dental visual aids showed effectiveness in improving OH status in children with ASD.
The Impact of Online-Schooling during COVID-19 on Device-Measured 24-Hour Movement Behaviours among High School Students: A Compositional Data Analysis
Authors: Starbek Petra , Kastelic Kaja , Šarabon Nejc
Published: May 2022

The COVID-19 measures have unfavourably affected the movement behaviours of youth. The aim of this study was to explore the impact of online-schooling during COVID-19 on device-measured sleep (SL), sedentary behaviour (SB), light physical activity (LPA), and moderate–vigorous physical activity (MVPA) among high school students. A total of 51 students (26 female) from Slovenia wore an activity monitor activPAL4 during the weekdays of onsite-schooling and during the weekdays of online-schooling. Data on movement behaviours were analysed using compositional data analysis. During the onsite-schooling (and online-schooling), students spent on average 432 min/day (469 min/day) in SL, 731 (755) in SB, 253 (202) in LPA, and 25 (15) in MVPA. Repeated measures multivariate analysis of variance confirmed significantly more time was spent in SL (log ratio 0.29; 95% CI 0.20, 0.37)) and SB (log ratio 0.23; 95% CI 0.13, 0.32) and less time in MVPA (log ratio −0.44; 95% CI −0.66, −0.23) during the online-schooling weekdays. Students spent significantly more time in SB during leisure (log ratio 0.20; 95% CI 0.06, 0.35) as well as during lecture time (log ratio 0.45; 95% CI 0.32, 0.58). Our results indicate that online-schooling significantly contributed to the unfavourable changes in students’ movement behaviours during COVID-19. Future studies should focus on developing physical activity interventions suitable for the circumstances of the epidemic.
The Effects of Adolescent Idiopathic Scoliosis on Axial Rotation of the Spine: A Study of Twisting Using Surface Topography
Authors: Thakur Ankush , Heyer Jessica H. , Wong Emily , Hillstrom Howard J. , Groisser Benjamin , Page Kira , Gmelich Caroline , Cunningham Matthew E. , Widmann Roger F. , Hresko M. Timothy
Published: May 2022

Axial twisting of the spine has been previously shown to be affected by scoliosis with decreased motion and asymmetric twisting. Existing methods for evaluating twisting may be cumbersome, unreliable, or require radiation exposure. In this study, we present an automated surface topographic measurement tool to evaluate global axial rotation of the spine, along with two measurements: twisting range of motion (TROM) and twisting asymmetry index (TASI). The aim of this study is to evaluate the impact of scoliosis on axial range of motion. Adolescent idiopathic scoliosis (AIS) patients and asymptomatic controls were scanned in a topographic scanner while twisting maximally to the left and right. TROM was significantly lower for AIS patients compared to control patients (69.1° vs. 78.5°, p = 0.020). TASI was significantly higher for AIS patients compared to control patients (29.6 vs. 19.8, p = 0.023). After stratifying by scoliosis severity, both TROM and TASI were significantly different only between control and severe scoliosis patients (Cobb angle > 40°). AIS patients were then divided by their major curve region (thoracic, thoracolumbar, or lumbar). ANOVA and post hoc tests showed that only TROM is significantly different between thoracic AIS patients and control patients. Thus, we demonstrate that surface topographic scanning can be used to evaluate twisting in AIS patients.
Identification of Emission Source Using a Micro Sampler Carried by a Drone
Authors: Cheng Wen-Hsi , Yuan Chung-Shin
Published: May 2022

A micro needle trap sampler (NTS) was carried by a mini quadrotor drone (Mavic Pro, DJI) to collect volatile organic compounds (VOCs) from industries. The NTS was fabricated using a 7 cm long, 22-gauge stainless steel needle by packing powdered divinylbenzene (DVB) adsorbents (60–80 mesh diameters). The telescoping sampling shaft was installed on the drone to extend the NTS beyond the downward air turbulence that was caused by the rotation of its propellers. The total mass of the sampling device, including an NTS, a telescoping shaft, a mini-air pump, and an ABS (acrylonitrile butadiene styrene) rack, was not more than 200 g. The emitted VOCs, those from a steel processing plant, including aromatic hydrocarbons (toluene of 15 ppb, ethylbenzene of 9 ppb and p-xylene 12 ppb), and those from a semiconductor processing factory, including trace amounts of methanol (1.96–2.00 ppm), acetone (0.05–0.10 ppm), and toluene (1.04–2.00 ppm), were extracted by the NTS on the drone and identified using a gas chromatography-mass spectroscopy (GC-MS) system in the laboratory. According to the results of VOC detection during the sampling flight of a drone, the stationary pollution sources were successfully identified.
The Aerodynamics of an Iron Ore Pelletizing Rotary Kiln
Authors: Larsson I. A. Sofia
Published: May 2022

This paper summarizes more than a decade of systematic studies of the flow field in an iron ore pelletizing rotary kiln using computational fluid dynamics (CFD) on simplified models of a real kiln. Physical, laser-based experiments have been performed to validate part of the numerical results. The objective is a better understanding of the kiln aerodynamics and, by extension, its effect on the combustion process. Despite all of the simplifications regarding the models studied in this project, the results show the importance of correctly predicting the flow field in order to optimize the combustion process. Combustion simulations revealed that the heat release from the flame does not affect or change the flow field in any significant way; the flow field, however, governs the flame propagation and affects the combustion process by controlling the mixing rates of fuel and air. Using down-scaled isothermal water models for investigating kiln aerodynamics in general and mixing properties in particular is therefore justified. Although the heat release from the flame cannot be accounted for in isothermal models, valuable implications regarding the real process can still be gained. To better model the actual process numerically, more advanced submodels for both the combustion and especially the flow field are needed. The complex flow field in this type of rotary kiln requires a careful choice of turbulence model to obtain accurate simulation results.
On Finding a Projected Coordinate Reference System
Authors: Stal Cornelis , De Sloover Lars , Verbeurgt Jeffrey , De Wulf Alain
Published: May 2022

The digital age has brought about an explosion in the growth of data, of which data with a geographical component stands out. Proper use of geographical data comes with the need for correct coordinate reference systems (CRSs). They are considered the ultimate binder for interoperability between geospatial data actors and stakeholders. Moreover, CRSs are crucial for the visual and analytical integration of geospatial data from disparate data sources. However, CRSs might be—for numerous reasons—incorrectly assigned or even missing. The result is a time-consuming study of the map, literature, and available resources to ultimately find the alleged right CRS. This study provides a summary of prevailing resources from national mapping agencies of some European countries to address the above problem. Secondly, and most importantly, is the development of an open-source Python-based software package. This software package aims to accurately estimate the best candidate CRS, given a tuple of coordinates at a priori an approximately known location. It is controlled by geocoding the known location and intersecting the resulting coordinate with the bounding box of all CRSs in the EPSG-database. An in-depth review of CRS tools by mapping authorities reveals, in particular, limitations concerning the countries’ spatial areas, in combination with often required know-how of local CRSs. To address these shortcomings, our tool is developed to enable a more generic extraction of CRSs for any given location worldwide. Testing proved successful for 30 different maps, with a grid present on the map and the CRS of the map being included in the EPSG-database.
Reply to Morone, G.; Giansanti, D. Comment on “Anwer et al. Rehabilitation of Upper Limb Motor Impairment in Stroke: A Narrative Review on the Prevalence, Risk Factors, and Economic Statistics of Stroke and State of the Art Therapies. Healthcare 2022, 10, 190”
Authors: Anwer Saba , Waris Asim , Gilani Syed Omer , Iqbal Javaid , Shaikh Nusratnaaz , Pujari Amit N. , Niazi Imran Khan
Published: May 2022

Thank you so much for your kind remarks [...]
Biological Factors in the Workplace—Current Threats to Employees, the Effects of Infections, Prevention Options
Authors: Garus-Pakowska Anna
Published: May 2022

Infectious diseases or communicable diseases are spread from person to person by various routs [...]
The Relationship between Korean Parents’ Smartphone Addiction and That of Their Children: The Mediating Effects of Children’s Depression and Social Withdrawal
Authors: Lim Shin-Il , Jeong Sookyung
Published: May 2022

With the number of smartphone users growing around the world, children are using smartphones from an increasingly early age. Consequently, a significant number of children are being exposed to the risk of smartphone addiction, which is emerging as a serious social problem. Smartphone addiction can negatively impact children’s physical, cognitive, and social development. Previous studies have demonstrated that parental smartphone addiction influences that of their children. Therefore, this study explores the relationship between parental smartphone addiction and children’s smartphone addiction and the mediating effects of children’s depression and social withdrawal. Data are drawn from National Youth Policy Institute’s 2018 Korean Children and Youth Panel Survey. Respondents comprise 2011 fourth-grade elementary school students and their parents. Data were analyzed using SPSS version 21.0 and AMOS 21.0 software. Results show that the relationship between parental smartphone addiction and that of their children has a significantly positive mediating effect on children’s social withdrawal, but no such effect on children’s depression and there were no serial effects of children’s depression and social withdrawal. Consequently, educational programs that control parents’ smartphone usage, improve the parent–child relationship, and engender social sensitivity should be developed to reduce and prevent smartphone addiction among children.
Urban Air Pollution and Emergency Department Visits for Neoplasms and Outcomes of Blood Forming and Metabolic Systems
Authors: Szyszkowicz Mieczysław , Lukina Anna , Dinu Tatiana
Published: May 2022

This study focused on investigating possible associations between exposure to urban air pollution and the number of emergency department (ED) visits for various health outcomes. The outcomes were grouped into four chapters of the International Classification of Diseases Tenth Revision (ICD-10) system (i.e., Chapter II-IV: “Neoplasms”, “Diseases of the blood”, “Endocrine, nutritional and metabolic diseases”, and XVIII: “Symptoms, signs and abnormal clinical and laboratory findings“). The data were collected for the city of Toronto, Canada, (2004–2015, 4292 days). Four gaseous air pollutants (carbon monoxide (CO), nitrogen dioxide (NO2), ground level ozone (O3), and sulfur dioxide (SO2)) and fine particulate matter (PM2.5), and two calculated air quality health indexes (AQHI) based on Toronto were used. The statistical models were constructed by applying the conditional Poisson regression. The exposure was assessed over a maximum of 15 days (time lags 0–14 days). An analysis was performed with the following strata: sex, age, and seasons. Relative risks (RR) and their 95% confidence intervals (95%CI) were estimated for an increase in concentration by a one interquartile range (IQR). For the AQHI (composed of NO2, O3, and PM2.5), IQR = 1, the estimations for lag 1 and all patients, are RR = 1.023 (95%CI: 1.008, 1.038), 1.026 (1.012, 1.040), 1.013 (1.003, 1.024), and 1.007 (1.003, 1.010) for Chapters II–IV and XVIII, respectively. The results show that in the four large, analyzed health groups, the impact of air quality mainly occurs over a short period (from current day to a maximum of 3 days after exposure).
Parental Feeding Practices in Families Experiencing Food Insecurity: A Scoping Review
Authors: Baxter Kimberley A. , Nambiar Smita , So Tsz Hei Jeffrey , Gallegos Danielle , Byrne Rebecca
Published: May 2022

Parental feeding practices and styles influence child diet quality and growth. The extent to which these factors have been assessed in the context of disadvantage, particularly household food insecurity (HFI), is unknown. This is important, as interventions designed to increase responsive practices and styles may not consider the unique needs of families with HFI. To address this gap, a scoping review of studies published from 1990 to July 2021 in three electronic databases was conducted. A priori inclusion criteria were, population: families with children aged 0–5 years experiencing food insecurity and/or disadvantage; concept: parental feeding practices/behaviours/style; and context: high income countries. The search identified 12,950 unique papers, 504 full-text articles were screened and 131 met the inclusion criteria. Almost all the studies (91%) were conducted in the United States with recruitment via existing programs for families on low incomes. Only 27 papers assessed feeding practices or styles in the context of HFI. Of the eleven interventions identified, two assessed the proportion of participants who were food insecure. More research is required in families outside of the United States, with an emphasis on comprehensive and valid measures of HFI and feeding practices. Intervention design should be sensitive to factors associated with poverty, including food insecurity.
Factors Associated with the Implementation of an Improved Community Health Fund in the Ubungo Municipality Area, Dar es Salaam Region, Tanzania
Authors: Mselle Goodluck , Nsanya Peter , Konlan Kennedy Diema , Lee Yuri , Ryu Jongsoo , Kang Sunjoo
Published: May 2022

Community-based health insurance schemes help households to afford healthcare services. This paper describes healthcare facilities and community factors that are associated with the Improved Community Health Fund (iCHF) scheme in the Ubungo district of Tanzania. A cross-sectional descriptive study was conducted using online questionnaires that were completed by healthcare providers and community members in public-owned healthcare facilities in the Ubungo Municipal Council district of Dar es Salaam, Tanzania, between October and November 2021. The data were analyzed using descriptive statistics and the chi-squared test of association. We found a statistically significant relationship between income level and satisfaction with the iCHF scheme. For community-related factors, income level was statistically significant in the level of involvement in iCHF implementation among local leaders. Further, income level was statistically significant in relation to community behavior/culture toward the iCHF. Occupation was statistically significant in iCHF implementation, iCHF premiums, and iCHF membership size. A statistically significant relationship was also found between income, iCHF membership size, and iCHF premiums. Moreover, people would be willing to pay the required premiums if the quality of the healthcare services under the iCHF scheme improves. Therefore, the government should allocate resources to reduce the challenges that are facing iCHF implementation, such as the preference for a user fee scheme over the iCHF, the issues that are faced by enrollment officers, and inadequate iCHF premiums and membership size.
Digital Tourism and Wellbeing: Conceptual Framework to Examine Technology Effects of Online Travel Media
Authors: Choi Youngjoon , Hickerson Benjamin , Lee Jaewon , Lee Hwabong , Choe Yeongbae
Published: May 2022

The current pandemic is accelerating the wide-spreading popularity of digital tourism. Given that technology innovation has broadened the horizon of tourist experiences to the realm of virtual environments, this study aims to (re)conceptualize travel experience and develop a theoretical framework to examine media technology effects on virtual travel experience, destination image, and tourists’ well-being. As a conceptual work, this study adopts technological perspectives on online travel media to decompose technology attributes and articulate distinctive effects of technology-centric variables. The proposed framework illustrates five propositions that specify and explain the relationships among technology-centric variables (modality, agency, interactivity, and navigability), three groups of moderators (user-centric, content-centric, and situation-centric variables), virtual travel experience, destination image, and psychological wellbeing. By adopting the variable-centered approach to decompose online travel media, this study provides a new theoretical lens to understand the psychological mechanism of media technology effects in digital tourism. The framework will serve as useful methodological guidelines to conduct experiments to investigate the distinctive effect of a particular affordance or a specific technical feature. The potential benefits of digital tourism to enhance tourists’ wellbeing are discussed by highlighting the environmentally friendly and inclusive aspects.
The EPH/Ephrin System in Bone and Soft Tissue Sarcomas’ Pathogenesis and Therapy: New Advancements and a Literature Review
Authors: Hadjimichael Argyris C. , Pergaris Alexandros , Kaspiris Angelos , Foukas Athanasios F. , Kokkali Stefania , Tsourouflis Gerasimos , Theocharis Stamatios
Published: May 2022

Musculoskeletal sarcomas represent rare heterogenous malignancies of mesenchymal origin that can be divided in two distinct subtypes, bone and soft tissue sarcomas. Current treatment options combine the surgical excision of local tumors and multidrug chemotherapy to prevent metastatic widespread disease. Due to the grim prognosis that usually accompanies such tumors, researchers have attempted to shed light on the molecular pathways implicated in their pathogenesis in order to develop novel, innovative, personalized therapeutic strategies. Erythropoietin-producing human hepatocellular receptors (EPHs) are tyrosine-kinase transmembrane receptors that, along with their ligands, ephrins, participate in both tumor-suppressive or tumor-promoting signaling pathways in bone and soft tissue sarcomas. The EPH/ephrin axis orchestrates cancerous processes such as cell–cell and cell–substrate adhesion and enhances the remodeling of the intracellular cytoskeleton to stimulate the motility and invasiveness of sarcoma cells. The purpose of our study was to review published PubMed literature to extract results from in vitro, in vivo and clinical trials indicative of the role of EPH/ephrin signaling in bone and soft tissue sarcomas. Based on these reports, significant interactions between the EPH/ephrin signaling pathway and a plethora of normal and abnormal cascades contribute to molecular mechanisms enhancing malignancy during sarcoma progression. In addition, EPHs and ephrins are prospective candidates for diagnostic, monitoring and therapeutic purposes in the clinical setting against bone and soft tissue sarcomas.
Numerical Simulation of Unsteady Cavitation Flow in a Low-Specific-Speed Centrifugal Pump with an Inducer
Authors: Cui Baoling , Han Xiaotian , An Yinchu
Published: May 2022

Cavitation is an undesirable phenomenon in the pumps. In this paper, unsteady cavitation flow in a low-specific-speed centrifugal pump with an inducer is investigated based on the full cavitation model and standard k-ε turbulence model using the commercial software PumpLinx. The numerical results of external performance curve and cavitation performance curve of design condition agree well with that of the experiment. The bubbles in the inducer mainly appear on the outer blade leading edge. The regions of larger vapor volume fraction in the inducer and impeller increase with the decreasing of NPSHa. The regions of larger vapor volume fraction in the inducer expand from the outer edge of the blade inlet to the hub on suction surface. Under very low NPSHa, the impeller may be filled with bubbles in the passage and the pump head drops drastically, and there exist distinct back flows near the suction surface of the blade and impeller outlet. Affected by pre-swirl of inducer outlet and the circle flow of impeller blade inlet, the amplitude of pressure fluctuation near the impeller inlet is obviously larger than that at the inlet in the inducer. The dominant frequency of pressure fluctuation for four monitoring points is shaft frequency. Compared with the non-cavitation flows, the maximum amplitudes of pressure pulsation increase for cavitating flow.
The Advent of Omics Sciences in Clinical Trials of Motor Neuron Diseases
Authors: Ruffo Paola , Cavallaro Sebastiano , Conforti Francesca Luisa
Published: May 2022

The “omics revolution” has totally changed the scientific research approach and is contributing to the development of personalized therapies. In motor neuron diseases (MNDs), a set of complex, multifactorial, late-onset and chronic neurodegenerative diseases, the use of multi-omics approaches in clinical trials is providing new opportunities to stratify patients and develop target therapies. To show how omics science is gaining momentum in MNDs, in this work, we review the interventional clinical trials for MNDs based on the application of omics sciences. We analyze a total of 62 clinical trials listed in the ClinicalTrials database where different omics approaches have been applied in an initial phase, for diagnosis or patient selection, or in subsequent stages to cluster subjects, identify molecular signatures or evaluate drugs security or efficacy. The rise of omics sciences in clinical experimentation of MNDs is leading to an upheaval in their diagnosis and therapy that will require significant investments and means to ensure the correct and rapid evolution of personalized medicine.
Management of Displaced Midshaft Clavicle Fractures with Figure-of-Eight Bandage: The Impact of Residual Shortening on Shoulder Function
Authors: Biz Carlo , Scucchiari Davide , Pozzuoli Assunta , Belluzzi Elisa , Bragazzi Nicola Luigi , Berizzi Antonio , Ruggieri Pietro
Published: May 2022

The treatment of displaced midshaft clavicle fractures (MCFs) is still controversial. The aims of our study were to evaluate clinical and radiological outcomes and complications of patients with displaced MCFs managed nonoperatively and to identify potential predictive factors of worse clinical outcomes. Seventy-five patients with displaced MCFs were enrolled and treated nonoperatively with a figure-of-eight bandage (F8-B). Initial shortening (IS) and displacement (ID) of fragments were radiographically evaluated at the time of diagnosis and immediately after F8-B application by residual shortening (RS) and displacement (RD). The clavicle shortening ratio was evaluated clinically at last follow-up. Functional outcomes were assessed using Constant (CS), q-DASH, DASH work and DASH sport scores. Cosmetic outcomes and rate of complications were evaluated. Good to very good mid-term clinical results were achieved by using the institutional treatment protocol. Multiple regression identified RS as an independent predictor of shoulder function, while RD affects fracture healing. These findings support the efficacy of our institutional protocol and thus could be useful for orthopedic surgeons during the decision-making process.
Using the DEMATEL Method to Identify Impediments to the Process of Determining Compensation for Expropriated Properties
Authors: Kwartnik-Pruc Anita , Ginda Grzegorz , Trembecka Anna
Published: May 2022

Laws governing the expropriation of real properties for public and socially useful purposes are in force in most countries. The problem of determining fair compensation for expropriated land is a very current one and has already been the subject of research. However, it deals mainly with the method of determining the value of the property without analyzing the procedure itself, and its weakest points in particular. The research objective is to develop a methodology to identify those factors that impede the entire process the most and should be eliminated in the first place. For this purpose, the authors firstly analyzed the procedure for determining compensation for expropriated real properties in Poland and identified factors that may adversely affect this process. Then, the decision support methods were reviewed. Due to the maturity, flexibility, and comprehensively verified quality, the DEMATEL method was used to achieve the research objective. This method allows for the efficient identification of all cause–effect relationships as well as key factors even in the case of very complex systems. Since the DEMATEL method is based on expert knowledge, the authors prepared a questionnaire and asked 16 experts—representatives of public administration at various levels, judges, and property appraisers—to assess the effect of individual factors on each other on a five-point scale. Finally, they analyzed the nature of the factors disturbing the course of the process of determining compensation for expropriated real properties. Thanks to the original multilevel application of the DEMATEL method, which took into account expert knowledge about the complex relationships between the factors, the authors demonstrated that in Poland the key roles in hindering the compensation determination process play two factors: the undetermined legal status and incomplete identification of real estate constituents. The proposed methodology is a universal one and may also be applied for the assessment of other administrative proceedings as well as various factors that determine them.
A Quantitative Analysis Method of Regional Rainfall-Induced Landslide Deformation Response Variation Based on a Time-Domain Correlation Model
Authors: Wu Tingchen , Xie Xiao , Wu Haoyu , Zeng Haowei , Zhu Xiaoya
Published: May 2022

Landslide deformation is the most intuitive and effective characterization of the evolution of landslides and reveals the inherent risk of landslides. Considering the inadequacy of existing deformation monitoring data for early warnings regarding landslide hazards, resulting in insufficient disaster response times, this paper proposes a time-domain correlation model. Based on the process of rainfall-induced landslide deformation, the time-domain correlation between regional rainfall and landslide deformation is proposed, which can reflect the temporal characteristics of landslide responses to rainfall, and the calculation method of the impulse response function is designed to quantitatively model and calculate the correlation. Furthermore, rainfall monitoring data are used to optimize the landslide deformation monitoring indicator system for early warnings regarding landslide instability. The feasibility of the method proposed in this paper is verified by analyzing the historical monitoring data of rainfall and landslide deformation at nine typical locations in five landslide hazard areas in Fengjie County, Chongqing city. (1) The correlation models for the XP landslide involve a delayed rainfall response time of 5 for deformation, respectively, as well as the existence of a cycle of 55–56 days, which means that the above area can advance the landslide warning by one lag time based on the cycle; (2) The correlation models for the OT landslide show consistent correlations under a 48–50-day cycle, which means that the deformation in the above areas can be predicted based on rainfall accumulation. (3) The HJWC landslide presents a turbulence correlation, which means that other monitoring data need to be supplemented and analyzed.
Impact of Storage Conditions on EV Integrity/Surface Markers and Cargos
Authors: Sivanantham Ayyanar , Jin Yang
Published: May 2022

Extracellular vesicles (EVs) are small biological particles released into biofluids by every cell. Based on their size, they are classified into small EVs (<100 nm or <200 nm) and medium or large EVs (>200 nm). In recent years, EVs have garnered interest for their potential medical applications, including disease diagnosis, cell-based biotherapies, targeted drug delivery systems, and others. Currently, the long-term and short-term storage temperatures for biofluids and EVs are −80 °C and 4 °C, respectively. The storage capacity of EVs can depend on their number, size, function, temperature, duration, and freeze–thaw cycles. While these parameters are increasingly studied, the effects of preservation and storage conditions of EVs on their integrity remain to be understood. Knowledge gaps in these areas may ultimately impede the widespread applicability of EVs. Therefore, this review summarizes the current knowledge on the effect of storage conditions on EVs and their stability and critically explores prospective ways for improving long-term storage conditions to ensure EV stability.
Thermal Effects in Slender EHL Contacts
Authors: Tošić Marko , Larsson Roland , Lohner Thomas
Published: May 2022

This study deals with experimental and numerical analysis of the thermal effects of slender elastohydrodynamically lubricated (EHL) contacts under high sliding. Thereby, the entrainment direction is along the major axis of the contact ellipse. Film thickness measurements were carried out on an optical EHL tribometer with a glass disk and steel roller. Numerical EHL solutions were obtained with consideration for non-Newtonian rheology and thermal effects. The results show that thermal effects can result in a strong viscosity wedge diverting oil flow to the contact sides. For high positive sliding, in which the glass disk moves faster, the influence of entrainment speed on minimum film thickness is almost negligible, while the film thickness shows a continuous decrease in gap length direction.
Nonlinear Elasticity Assessment with Optical Coherence Elastography for High-Selectivity Differentiation of Breast Cancer Tissues
Authors: Gubarkova Ekaterina V. , Sovetsky Aleksander A. , Matveev Lev A. , Matveyev Aleksander L. , Vorontsov Dmitry A. , Plekhanov Anton A. , Kuznetsov Sergey S. , Gamayunov Sergey V. , Vorontsov Alexey Y. , Sirotkina Marina A. , Gladkova Natalia D. , Zaitsev Vladimir Y.
Published: May 2022

Soft biological tissues, breast cancer tissues in particular, often manifest pronounced nonlinear elasticity, i.e., strong dependence of their Young’s modulus on the applied stress. We showed that compression optical coherence elastography (C-OCE) is a promising tool enabling the evaluation of nonlinear properties in addition to the conventionally discussed Young’s modulus in order to improve diagnostic accuracy of elastographic examination of tumorous tissues. The aim of this study was to reveal and quantify variations in stiffness for various breast tissue components depending on the applied pressure. We discussed nonlinear elastic properties of different breast cancer samples excised from 50 patients during breast-conserving surgery. Significant differences were found among various subtypes of tumorous and nontumorous breast tissues in terms of the initial Young’s modulus (estimated for stress < 1 kPa) and the nonlinearity parameter determining the rate of stiffness increase with increasing stress. However, Young’s modulus alone or the nonlinearity parameter alone may be insufficient to differentiate some malignant breast tissue subtypes from benign. For instance, benign fibrous stroma and fibrous stroma with isolated individual cancer cells or small agglomerates of cancer cells do not yet exhibit significant difference in the Young’s modulus. Nevertheless, they can be clearly singled out by their nonlinearity parameter, which is the main novelty of the proposed OCE-based discrimination of various breast tissue subtypes. This ability of OCE is very important for finding a clean resection boundary. Overall, morphological segmentation of OCE images accounting for both linear and nonlinear elastic parameters strongly enhances the correspondence with the histological slices and radically improves the diagnostic possibilities of C-OCE for a reliable clinical outcome.
Photocurable Hydrogel Substrate—Better Potential Substitute on Bone-Marrow-Derived Dendritic Cells Culturing
Authors: Deng Jiewen , Xie Yao , Shen Jian , Gao Qing , He Jing , Ma Hong , Ji Yongli , He Yong , Xiang Meixiang
Published: May 2022

Dendritic cells (DCs) are recognized as the most effective antigen-presenting cells at present. DCs have corresponding therapeutic effects in tumor immunity, transplantation immunity, infection inflammation and cardiovascular diseases, and the activation of T cells is dependent on DCs. However, normal bone-marrow-derived Dendritic cells (BMDCs) cultured on conventional culture plates are easy to be activated during culturing, and it is difficult to imitate the internal immune function. Here, we reported a novel BMDCs culturing with hydrogel substrate (CCHS), where we synthesized low substituted Gelatin Methacrylate-30 (GelMA-30) hydrogels and used them as a substitute for conventional culture plates in the culture and induction of BMDCs in vitro. The results showed that 5% GelMA-30 substrate was the best culture condition for BMDCs culturing. The low level of costimulatory molecules and the level of development-related transcription factors of BMDCs by CCHS were closer to that of spleen DCs and were capable of better promoting T cell activation and exerting an immune effect. CCHS was helpful to study the transformation of DCs from initial state to activated state, which contributes to the development of DC-T cell immunotherapy.