bluuebunny/crossref_metadata_2025 huggingface dataset:
Age and generation conditions of quartz crystal deposits in the Subpolar Urals
Authors: Burlakov E. V. , Ivanov K. S. , Berzin S. V. , Travin A. V. , Khanin D. A.
Published: January 2024

Research subject. The Dodo and Puiva quartz crystal deposits in the Neroiskiy mineral province (Subpolar Urals) were studied. Although these deposits have received sufficient research attention, a number of issues remain to be elucidated, including the age of crystal-bearing mineralization and the age of host rocks. Aim. In this work, we aim to determine the age of the metasomatites that bear quartz crystal mineralization and to develop a model of the formation of the Dodo and Puiva deposits. Materials and Methods. 40Ar/39Ar dating was carried out according to the method described by A.V. Travin et al. The argon isotope composition was measured on a Micromass 5400 mass spectrometer (IGM SB RAS). Results. Microprobe studies of the mineralogy of the Dodo and Puiva quartz crystal deposits were carried out. The temperatures of meta-somtaite formation were determined to range within 339–364°C. Six main structural and morphological types of quartz veins were identified and described. The 40Ar/39Ar ages of mica of quartz crystal deposits and host metamorphic schists were determined. Reliable plateaus were obtained, the values of which ranged within 251–257 Ma and agreed with each other within the deviation (average for 4 dates is 255 ± 2 Ma). Conclusion. A new model for the formation of quartz crystal deposits in the Subpolar Urals is proposed. The obtained 40Ar/39Ar ages correspond to the period of the post-orogenic extension of the Urals. At that time, a system of meridional grabens and rifts was formed in the Urals and in the West Siberian Plate. At the same time, and as a result of the same stretching impulse, large blocks of the middle crust (granite, schist, etc.) were brought to the Earth’s surface in the Urals. During the rise of deep blocks, at a depth of 10 km, a sharp, approximately 3-fold drop in fluid pressures (from lithostatic to hydrostatic) and a strong decrease in temperatures due to adiabatic expansion and the throttling effect occurred. The obtained 40Ar/39Ar ages (255 Ma) reflect not only the age of the quartz crystal deposits of the Subpolar Urals, but also place the moment of rise of the entire Central Ural uplift above a depth of 10 km, i.e., to the level of the upper cortex.
Bindungstheorie und personzentrierte Beziehungsgestaltung: Überlegungen zu einem ‚allgemeinen Wirkfaktor‘
Authors: Gahleitner Silke Brigitta
Published: January 2024

Der Erfolg professioneller Begleitung steht und fällt mit der Qualität der helfenden Beziehung – inzwischen eine über verschiedene Therapieansätze hinweg gut belegte Erkenntnis. Wie genau diese Beziehung sich jedoch gestaltet, ist bis heute in Forschung und Theoriebildung noch erstaunlich ungeklärt. Die Bindungsforschung, die in den letzten Jahren zunehmend Ergebnisse für die therapeutische Praxis entwickelt und zugänglich machte, hat hier einen entscheidenden Beitrag geleistet. Die Erfahrung, dass Muster gelingender Interaktion eine wichtige Grundlage für helfende Berufe darstellen, lässt sich durch dieses Konzept besser systematisieren. Der vorliegende Artikel beleuchtet Bindungsphänomene in ihrer Bedeutung für die therapeutische Beziehungsgestaltung im Dialog mit klientenzentrierter Theorie und ermöglicht einen Einblick in die Kraft der Ressource ‚Beziehung‘ für die personzentrierte Beziehungsgestaltung.
Incidencia de la altura para la medición de la calidad del aire de PM10 y PM2,5 como parte del cumplimiento del objetivo y características de los SVCA
Authors: Murad Pedraza José Alejandro , Roa Martínez Miguel Angel , Roa Martínez Manuel Ricardo
Published: January 2024

Los Sistemas de Vigilancia de Calidad del Aire buscan determinar el cumplimiento de las normas de calidad del aire, y a su vez evaluar los riesgos para la salud pública y el ambiente. La falta de conocimiento y de precisión al momento de aplicar algún criterio de diseño y validación de los Sistemas de Vigilancia de Calidad del Aire, puede generar incertidumbre en la veracidad de los datos. La presente investigación pretende establecer la concentración de PM10 y PM2.5 a 2 y 10 m de altura para la determinación de su incidencia en el resultado de las mediciones. Se llevaron a cabo las mediciones en la Universidad Distrital Francisco José de Caldas en la facultad FAMARENA Bosa El Porvenir y en la facultad De Artes ASAB, durante un periodo de 7 meses, donde adicionalmente se desarrollaron análisis climatológicos, estadísticos, de correlación y comparación. Los niveles de concentración fueron mayores a 2 m de altura en los dos puntos de estudio, debido a que superan más del 60% del total de datos para cada parámetro. Adicionalmente, se evidenció que PM10 y PM2.5 en ambos puntos de medición, presentan a nivel general diferencias de concentración de 5 a 15 µg/m3 y concentraciones máximas de 40 µg/m3. La altura cuenta con una significativa incidencia en la medición independientemente de su origen, convirtiéndose en una variable a evaluar para diseñar un Sistema de Vigilancia de Calidad del Aire.
Adsorción de mercurio sobre nanopartículas de hierro soportadas en fibra de Fique: cinética e isoterma de adsorción
Authors: Zea Ramírez Hugo Ricardo , Bastidas Gómez Karen Giovanna , Sierra Ávila Cesar Augusto
Published: January 2024

Se estudia la adsorción de iones de mercurio de una solución acuosa sobre un adsorbente (fibra de fique con nanopartículas de hierro). Se estudió el efecto del pH, la concentración inicial de iones de mercurio ([Hg+2]) y la carga de hierro (Fe % peso) en el material adsorbente. De las superficies de respuesta experimentales obtenidos se infiere que en la adsorción de mercurio predomina el mecanismo de quimisorción respecto a la fisisorción. Se utilizaron las isotermas de Langmuir y Freundlich para describir la adsorción física del mercurio; sin embargo, no lograron describir adecuadamente la mayoría de las isotermas experimentales obtenidas. Se estableció que la cinética de adsorción de mercurio en la superficie de la fibra de fique con nanopartículas de hierro se describe mediante un modelo de pseudo-segundo orden que involucra la quimisorción (reacción química) como mecanismo de control de la velocidad, lo que indica que el proceso de adsorción es irreversible. El pH no tiene ningún efecto aparente sobre la adsorción en el rango de pH 4 a 7; sin embargo, para un pH superior a 8, la capacidad de adsorción aumenta a medida que aumenta el valor del pH.
Categorización e integración de columnas de opinión y contenido de páginas web aplicando técnicas de Procesamiento de Lenguaje Natural
Authors: Acevedo-Castiblanco Jorge-Alexander , Suarez-Barón Marco-Javier , González-Sanabria Juan-Sebastián
Published: January 2024

Se presenta la aplicación de técnicas de Procesamiento de Lenguaje Natural para el análisis de textos, describiendo el proceso realizado desde la extracción de datos hasta la identificación y detección de opiniones de manera automática. Los textos analizados fueron columnas de opinión que reflejan los criterios de las personas sobre temas de actualidad. Lo anterior con el fin de proporcionar una manera ágil de identificar los temas de interés en la comunidad para proporcionar a los interesados de forma resumida lo que se expresa sobre estos temas. Para tal fin, se implementó un algoritmo que permite extraer información de manera precisa y limpia desde páginas web y posteriormente otro algoritmo que se encarga de efectuar la categorización automática de la información extraída, generando un resumen preciso de los principales temas en cada escrito.
Forms and methods of preventing crimes in the field of drug trafficking
Authors: Kutsev Vladimir Valentinovich
Published: January 2024

The subject of this study is the forms and methods of preventing crimes in the field of drug trafficking. The purpose of the study is to analyze the forms and methods of preventing drug crimes, their differentiation, identify current problems and develop ways to solve them. Attention is drawn to the fact that the main actors in the prevention of drug crime are the state and society. The role of the state is to coordinate and determine the vectors of combating drug crime, draw up plans and programs for preventive activities, and determine the competence of other subjects of prevention. Society also plays an important role in reducing drug crime, so it is important to involve citizens in the prevention of crimes in the field of drug trafficking. It is determined that the feedback mechanism contributes to the qualitative interaction of civil society institutions with law enforcement agencies and government agencies.  The research methodology includes a number of general scientific methods of scientific cognition. The following methods were used in the course of the research: the method of analysis and synthesis, methods of deduction and induction, the method of analyzing scientific literature, the method of systematization, formal legal, dialectical and other methods. The research is structured according to the principles of logic and structuring. The scientific novelty of this study is to highlight the urgent problems of drug crime prevention as one of the methods of preventing crimes in the field of drug trafficking. Special attention is paid to improving the practice of social rehabilitation of drug addicts. This topic has been the subject of scientific research, but the main focus of many researchers is on drug treatment. At the same time, social rehabilitation and employment of drug addicts are of no less importance, as they seriously reduce the likelihood of such persons committing crimes in the field of drug trafficking. The considered method of preventing drug crimes, expressed in individual preventive work with drug addicts, will also contribute to reducing the demand for drugs, which will reduce the number of crimes in the field of illicit trafficking. The conducted research allowed us to conclude that such a method of preventing crimes in the field of drug trafficking as individual preventive work with drug addicts, their adaptation and social rehabilitation is of high importance. Some problems in this area are considered, and possible solutions are proposed.
Aplikasi Mobile Sederhana Ulfa’s Flower Shop dengan Bahasa Dart Menggunakan Framework Flutter
Authors: Ulfa Ladayya  , Nuur Wachid Abdulmajid
Published: January 2024

Abstrak: Zaman semakin berkembang, teknologi bukanlah hal yang asing bagi manusia di seluruh dunia. Teknologi sudah masuk ke kehidupan setiap lapisan masyarakat. Dengan adanya teknologi semua aktivitas manusia menjadi mudah. Salah satu contohnya adalah adanya aplikasi yang memudahkan semua orang dalam menyelesaikan masalahnya. Misalnya mencari bunga yang diinginkan di toko bunga. Seperti yang diketahui bunga sangat digemari oleh semua kalangan masyarakat. Seringkali jika ada sebuah acara pastilah seseorang akan membeli buket bunga untuk diberikan kepada orang yang ditujunya. Namun, permasalahan yang terjadi ialah ketidaktahuan jenis-jenis bunga apa saja yang tersedia di toko tersebut. Bahkan banyak konsumen yang tidak mengetahui ketersediaan atau tidaknya bunga yang mereka cari. Tujuan dibuatnya artikel dari aplikasi ini ialah agar konsumen mudah untuk melihat jenis bunga yang ada di toko, detail bunganya, memesan bunga hanya untuk disimpan agar tidak kehabisan, dan dapat juga memesan kartu ucapan. Metode yang digunakan dalam penelitian ini ialah metode survei, kajian literatur, dan model pengembangan ADDIE. Aplikasi ini dibangun dari Bahasa dart dengan framework flutter. Dengan kehadiran teknologi kita dapat memanfaatkannya dengan membangun aplikasi untuk memasarkan bisnis digital yang sedang dijalani. Tentu aplikasi informasi seperti yang peneliti buat sangat berguna dan mempermudah user dalam mencari jenis bunga yang tersedia, harga, dan warna yang ingin dibeli tanpa harus ke toko terlebih dahulu.
Perencanaan Strategis Sistem Informasi Sekolah Musik Dengan Metode Ward and Peppard dan Anita Cassidy
Authors: Kanggep Kanggep Andrijana Kusuma , Naufal Alman , Ratna Juwita Sari Deassy , Dwicahya Supriatman Rian , Maulani Shanti
Published: January 2024

Bisnis sekolah musik sangat sesuai untuk penerapan suatu strategi sistem informasi karena salahsatu tujuannya berkaitan dengan kepuasan pelanggan yang membutuhkan strategi bisnis yang dapat menunjang tercapainya tujuan organisasi. Maka dipandang perlu suatu perencanaan strategis sistem informasi untuk meningkatkan daya saing bisnis bagi sekolah musik. Penelitian yang dilakukan bertujuan untuk menganalisis situasi sekolah musik., untuk dapat memberikan usulan strategi sistem informasi yang efisien serta efektif dalam pencapaian tujuan organisasi di sekolah musik. Pada penelitian ini penulis observasi langsung ke salah satu sekolah musik yaitu Majestic Symphony Music School Bandung untuk mendapatkan data, dokumen, serta melakukan wawancara kepada pelaku bisnis sebagai bahan sumber informasi yang dibutuhkan oleh penulis. Pendekatan yang digunakan untuk menyusun kerangka kerja pada penelitian ini, penulis menggunakan Ward and Peppard dan Anita Cassidy untuk melakukan analisis terhadap faktor-faktor internal dan eksternal. Hasil akhir dari penelitian ini adalah Perencanaan Strategi sistem Informasi dan teknologi Informasi bagi sekolah musik berupa kebutuhan aplikasai sistem Informasi. Rancangan perubahan struktur organisasi, kebutuhan Infrastruktur teknologi informasi, Portofolio Sistem Informasi serta Teknologi Informasi di masa yang akan datang serta Rencana Strategis Sistem Informasi dan Teknologi Informasi bagi sekolah musik. Saran dari penelitian ini adalah harus disiapkan SDM yang memadai sebelum sistem baru dipergunakan dan telah dilakukan testing terhadap sistem baru sebelum diputuskan untuk dioperasikan.
Perancangan Sistem Informasi Sekolah Dasar Berbasis Website Menggunakan Metode Rapid Application Development
Authors: Esya Ardhana Farhan , Parga Zen Bita
Published: January 2024

Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi Republik Indonesia (Kemendikbudristek) Republik Indonesia telah mendorong dan memberikan panduan kepada sekolah-sekolah di Indonesia untuk memiliki Website sebagai bagian dari upaya untuk meningkatkan transparansi dan aksesibilitas informasi pendidikan. Namun, aturan terkait wajibnya setiap sekolah memiliki Website berbeda di setiap daerah atau provinsi, sehingga penting untuk memeriksa pedoman yang dikeluarkan oleh dinas pendidikan setempat. Penelitian ini bertujuan untuk membangun Website sistem informasi sekolah di SD Negeri 1 Pasir Kidul. Sekolah tersebut belum memiliki Website sebagaimana yang diarahkan oleh Kemendikbudristek. Ketidakadaan website di sekolah tersebut menyebabkan penyebaran informasi kepada Masyarakat terhambat, promosi sekolah terhadap masyarkat kurang baik, sehingga website sistem informasi dibutuhkan bagi sekolah. Website sistem informasi sekolah tersebut dikembangkan dengan pendekatan Rapid Application Development (RAD). Metode RAD dipilih karena sangat efisien dibandingkan dengan metode lain yang membutuhkan waktu penelitian yang lebih lama. Melalui metode RAD dapat mempercepat proses pembangunan Website sistem informasi dan memastikan bahwa sistem yang dihasilkan sesuai dengan kebutuhan sekolah. Hasil dari penelitian ini adalah sistem informasi berupa Website yang bertujuan untuk menyebarkan informasi SD Negeri 1 Pasir Kidul dengan menampilkan informasi sekolah, galeri sekolah, kegiatan yang ada pada sekolah, serta Penerimaan Peserta Didik Baru (PPDB). Website yang telah dibangun dilakukan pengujian dengan menerapkan metode Black Box Testing. Hasil dari Black Box Testing membuktikan bahwa Website SD Negri 1 berjalan sesuai dengan kebutuhan.
New and interesting records of Lepidoptera for several Russian regions
Authors:   Zoological Institute of the Russian Academy of Sciences, St. Petersburg, 199034, Russia, Makhov I.A. , Lukhtanov V. A. ,   Zoological Institute of the Russian Academy of Sciences, St. Petersburg, 199034, Russia, Matov A.Yu. ,   Zoological Institute of the Russian Academy of Sciences, St. Petersburg, 199034, Russia
Published: January 2024

The new findings of 14 species of Lepidoptera from 5 families are reported for 10 Russian regions: Volga-Don region, South Ural region, Krasnoyarsky Krai, Irkutskaya Oblast, Republic of Buryatia, Zabaikalsky Krai, South Yakut region, East Yakut region, Amurskaya Oblast, Primorsky Krai, and 3 rare species recently discovered in Russia. One species, Maliattha signifera (Walker, [1858]), is recorded in Russia for the first time. The records of Crocota niveata (Scopoli, 1793) for Volga-Don region and Abraxas latifasciata Warren, 1894 for Primorsky Krai are confirmed.
Eulophid wasps of the subfamily Eulophinae (Hymenoptera: Chalcidoidea) from the Khingan Reserve (Amur Province, Russia), with the descriptions of new species
Authors:   All-Russian Institute of Plant Protection, Podbelskiy Shosse, 3, St Petersburg, Pushkin 196608, Russia, Kosheleva O.V.
Published: January 2024

Four eulophinae species, Cirrospilus kochetkovi sp. n., Elachertus khingansis sp. n., Elachertus uriliensis sp. n. and Sympiesis bimaculae sp. n. are described from south-eastern part of Amur Province. Seventeen species from the nine genera, Cirrospilus Westwood, 1832 (1 species), Diglyphus Walker, 1844 (1), Dimmockia Ashmead, 1904 (1), Elachertus Spinola, 1811 (5), Eulophus Geoffroy, 1762 (1), Euplectrus Westwood, 1832 (2), Hemiptarsenus Westwood, 1833 (2), Pnigalio Schrank, 1802 (1), and Sympiesis Foerster, 1856 (3 species), are new for the fauna of Amur Province. Cirrospilus isonoi Kamijo, 1987, Elachertus longipetiolus Bouček, 1971, and Euplectrus maculiventris Westwood are recorded from the fauna of Russia for the first time.
Prevalência de doenças cardiovasculares em pacientes portadores de HIV
Authors: Vilar Dandara Alice Rodrigues , Macambira Alinne Katienny Lima Silva
Published: January 2024

Objetivo: Apontar a prevalência de doenças cardiovasculares em pacientes com HIV. Métodos: Trata-se de uma revisão integrativa da literatura, a qual buscou os estudos clínicos publicados em língua inglesa, portuguesa ou espanhola nos últimos 5 anos nas bases de dados da Medline/PubMed, Scopus e LILACS através de critérios de inclusão e exclusão bem estabelecidos. Resultados: Após processo minucioso de seleção de estudos, foram incluídos 23 artigos clínicos na amostra final. No total, foram 30.577 pacientes, sendo destas 28.716 pessoas que vivem com HIV (HIV+) e 1.861 pessoas com teste de HIV negativo (HIV-). Foram observadas diversas doenças cardiovasculares (DCV), com destaque para Hipertensão Arterial Sistêmica. A associação com sexo, idade, contagem de CD4, carga viral e tempo médio de infecção por HIV foi analisada na maioria dos estudos. Todos os estudos apontaram uma maior prevalência da DCV analisada quando comparada com a população em geral, com a exceção de um estudo. Considerações finais: Desta forma, considera-se que as DCV são mais prevalentes em pessoas que vivem com HIV. Sendo assim, é imprescindível o manejo mais próximo dessas condições nestes pacientes.
Development and Evaluation of Eplerenone Microbeads as Floating Drug Delivery System using Design of Experiment
Authors: Boorugu Rambabu , GV Radha
Published: January 2024

The present study was designed to formulate floating microbeads of eplerenone for decreasing dosing frequency and increasing gastric residence. The floating properties of the gastric juice were used to control the stomach stay time. Eplerenone was selected as a model bioactive which is used in lowering blood pressure by loading into floating microspheres was designed by using polymer ethyl cellulose and solvent ratio (Dichloromethane: methanol), keeping. The floating microbeads were studied for their drug entrapment efficiency, shape, percentage yield, and particle size, surface morphology, in-vitro drug release studies, percentage buoyancy, and formulation stability studies. Dichloromethane we used (DCM) as a constant and stirred them for hours. The study showed that fluid evaporation can be used to make floating microbeads that contain eplerenone. This method can be used to successfully make eplerenone-loaded floating microbeads. The study showed that making floating eplerenone microbeads with controlled release is a good way to cut down on how often you have to take your medicine.
Development of Stability Indicating Method for the Quantification of Futibatinib in K2EDTA Human Plasma by LC-MS/MS
Authors: Jogeswararao P , Bhikshapathi DVRN
Published: January 2024

sensitive, accurate, and linear LC-MS/MS method for the quantification of futibatinib in human plasma K2 ethylene diamine tetraacetic acid (EDTA) was developed. A Phenomenex C18, 150×4.60 mm, 2.1 μ column, 0.1% HCCOH, ACN and methyl alcohol (13/67/20, v/v/v) mobile solvent system at 0.8 mL/min was employed for the isolation of components.10 μL. of volumes were employed to isolate the peak responsess within 2.0 minutes at 40 ± 5ºC of oven temperature. Analyte retention was 1.261 minutes and ISTD of 1.292 minutes. Throughout the process of validation, each of the four calibration curves exhibited linear behavior for standards with concentrations ranging from 0.16 to 3250 ng/mL. Validation showed an r2 = 0.9997. At MQC, HQC, and LQC concentrations, futibatinib had 98.49, 99.35, and 98.47% mean recovery. Every QC level had a mean recovery of 90.51% and a %CV of 3.06. All of the control solutions had back-calculated concentration values that were accurate between 94.61 and 98.86% of the time. The range of %CV of back-calculated values for all quality control samples were in the range of 0.6 and 4.63, which is within the acceptable range of 15%. The developed method can be applied successfully for the quantification of the Futibatinib in biological matrices.
Comparative Characterization of Reference Market Product and Generic Product Developed using Reverse Engineering Methodology
Authors: S Jailani , Dhanapal C K , Khan Noohu A
Published: January 2024

The present study is a comparative analysis between the reference market product, Xarelto® 20 mg film-coated tablets, and a generic product developed using reverse engineering methodology, employing low-shear ethanolic granulation. The primary objective in formulating and optimizing this generic product was to attain a formulation that exhibits both physical and chemical stability, closely resembling the innovator or market reference drug product. Both reference and generic products were evaluated using FTIR, TGA, DSC, XRD, SEM, EDX/EDS, Raman mapping, Raman imaging and contact angle measurement studies and were compared. Similar characteristic peaks were observed in the IR spectra of the generic product (RX-LS [AH]) to that of the reference product. Similar crystallinity was detected between reference and generic products. The TG-DSC analysis confirmed the presence of a similar endothermic peak of the generic product to that of the reference product. SEM images showed the presence of deformed granules in both, generic and reference products due to the compression force during tablet production. The specific and major elements present in both samples were C, N, O, Na, Mg, S and Cl. The API and excipient distribution within the reference product and the generic product is closely similar confirmed through the Raman study. Test (θ = 17.3) and reference products (θ = 17.9) showed contact angles around 17 degrees, it indicates that both products have similar wettability capacity, in other words, similar solubility and dissolution behavior. The current study demonstrated the excellent similarity of generic Rivaroxaban 20 mg film-coated tablets with reference products. The exactly similar characteristics of generic products will definitely boost confidence of successful bioequivalence studies and reduce developmental cost and time as there is no a chance of product failure which will lead to redevelopment.
Phyto-pharmacological Investigation of Plumbago zeylanica for Memory Enhancing Activity
Authors: Padarthi Pavan K , Samanthula Kumara S , Kumar Pushpendra , Jallepalli Venkateswara R , Deshpande Mangirish
Published: January 2024

Objective: The main goal was to assess the possible memory-enhancing effects of Plumbago zeylanica root extract on Wistar rats. Materials and Methods: Extract of P. zeylanica roots evaluated for memory enhancement by Morris water maze (MWM) and elevated plus maze (EPM). Here, the parameter examined was transfer latency (TL). Results: There was a dose-dependent decline in TL when P. zeylanica root extract was administered, as compared to the control. Conclusion: The observed dose-dependent reduction in transfer latency provides compelling evidence of the extract’s potential in countering neurodegeneration and affirming its nootropic capabilities.
A Flavonoid-rich Fraction of Alternanthera pungens Ameliorates Hyperglycaemia -mediated Memory Dysfunction in Diabetic Rats
Authors: Momina Sayyada S , Gandla Kumaraswamy
Published: January 2024

The central nervous system (CNS) undergoes alterations due to persistent hyperglycemia and cholinergic dysfunction, leading to cognitive impairment associated with diabetes (T2DM). Animal studies have shown that acetylcholinesterase (AChE) inhibitors and anti-diabetics are effective. Considering the impressive potential of natural products in treating DM and AD, the present research set out to assess the neuroprotective effects of a methanolic extract of Alternanthera pungens (MEAP) against cognitive impairment in mice caused by hyperglycemia. Hence, we used the mobile workforce management (MWM) and enterprise performance management (EPM) assays to analyze for cognitive impairment in diabetic rats. 30 days after the initiation of T2DM, rats had hyperlipidemia, increased escape latency in EPM tasks, and decreased time spent in the TSTQ during probe trials in the MWM. They also displayed notable and persistent hyperglycemia throughout training trials. Changes in blood glucose, lipid, and liver profiles, as well as performance in MWM and EPM tests, were averted in STZ-induced T2DM rats treated with MEAP (200 and 400 mg/kg). In a separate series of experiments, flavonoids (i.e., quercetin and rutin) were detected by the standardization of the extract using high performance thin layer chromatography (HPTLC). Inhibitory actions against alpha-amylase and alpha-glucosidase demonstrate that both of these flavonoids are potent antidiabetic agents that reduce intestinal glucose absorption. Lastly, the inclusion of these flavonoids in the extract from A. pungens is responsible for its action, suggesting that it may provide a novel strategy for preventing cognitive deterioration in diabetes.
A QbD Assisted Bioanalytical Method Development and Validation for Simultaneous Estimation of Montelukast and Bilastine by LC-MS Technique
Authors: Gnanasekaran D , Gandhimathi R
Published: January 2024

This study describes how to use internal standards (IS) under the Analytical Quality by Design (AQbD) methodology to measure montelukast and bilastine in artificial rabbit plasma. The protein precipitation method was used for sample preparation and extraction. The chromatographic analysis was performed on the processed materials. The measurement range of the calibration was between 2 to 40 ng/mL for Bilastine and 1 to 20 ng/mL for montelukast. Optimizing mobile phase composition, flow rate, and pH were used to determine peak area and retention time. A significant reduction in method variability was observed as a result of the method of experimental design during optimization, and this enhanced the stability of the technique. A validation study demonstrated linearity, accuracy, precision, selectivity, sensitivity, and stability for estimating bilastine and montelukast in rabbit plasma using the developed method. The chemical composition of the drug was not altered during tests on its stability in human plasma. Overall, the investigations showed that the established approach is straightforward, reliable, and affordable for use in regular pharmacokinetic and bioequivalence research.
Response Surface Methodology Assisted RP-HPLC Method for the Determination of Meropenem in Human Plasma: Application to a Pharmacokinetic Study
Authors: P Jyothikrishna , Karthika Anoop , Nagappan Krishnaveni , M Deepalakshmi , KP Arun
Published: January 2024

A simple, accurate and precise development of an reversed-phase high-performance liquid chromatography (RP-HPLC) method for the quantification of meropenem in human plasma samples for therapeutic drug monitoring (TDM) was developed and validated after optimization of various chromatographic parameters. The best recovery of meropenem was achieved through sample preparation based on a simple extraction method that included deproteinization and extraction with acetonitrile. The developed method reported acceptable values for selectivity, linearity, accuracy and precision, carry-over, dilution integrity and stability. The developed method was efficiently shown to be applicable to a real-time monitoring and pharmacokinetic study of meropenem in critically ill patients.
Synergistic Antifungal Bioassay of Neem Leaves Extract with Essential Oils against Dermatophytes
Authors: Tiple Rupali , Jamane Shamli , Khobragade Deepak , Sharma Shital
Published: January 2024

Introduction: The neem plant is also known as a panacea in dentistry due to its antimicrobial properties and plays vital role in the cosmetic industry as it is extensively used in cosmetic preparations for hair and skin care. Objective: The present study was carried out to evaluate the synergistic activity of essential oils in combination with neem leaves ethanolic extracts. Methods: The antifungal activity of neem leaves (Azadirachta indica) ethanolic extracts in combination with A. indica, Eucalyptus citriodora and Cymbopogon martini essential oils was conducted by agar well diffusion method followed by M38-A2 broth microdilution method on pathogenic dermatophytes strains; Microsporum gypseum, Trichophyton mentagrophytes and T. rubrum. Neem leaves extract was obtained by treating the matured green leaves with ethanol. Moreover, HPLC analysis was performed to narrate the terpenoid content having extensively noted antifungal spectrum. The potent antimycotic fluconazole taken as a positive control. Result: The result exhibited that there was overall growth retardation of the dermatophytes at minimum inhibitory concentration between 125 to 250 μg/mL for leaves extract and between 0.078 to 5.0 μL for selected essential oils. The range of minimum inhibitory concentration (MIC) of fluconazole was found between 0.25 and 0.50 μg/mL. Conclusion: Neem leaves ethanolic extracts analysis showed the possible existence of terpenoids in extracts that are recognized having extensive biological action. The outcomes of this study showed a novel report on the therapeutic potential of neem leaves extract with A. indica, E. citriodora and C. martini to control dermatophytosis. The neem leaf extract and antifungal herbal oil in combination have been proven to improve and broad-spectrum antifungal activity and they can be formulated in suitable formulations for the effective treatment of mycosis.
Exploring the Therapeutic Potential of Allium sativum: Recent Advances and Applications
Authors: Dhakar Suresh , Tare Harshal , Jain Sachin K
Published: January 2024

This review dives into the multidimensional character of Allium sativum, generally known as garlic, exploring its botanical aspects, chemical elements, and varied pharmacological effects. With a complex array of sulfur compounds, amino acids, enzymes, and minerals, garlic has long been renowned for its strong flavor and therapeutic potential. Allicin and its derivatives are the focus of this research as it investigates the medical uses of garlic’s numerous sulfur compounds. Garlic has a wide variety of biomolecules, and this article investigates their potential synergistic effects on health to highlight the need for additional study in this field. Garlic’s pharmacological actions are also described in detail, providing insight into its prospective therapeutic applications. These activities range from its antiatherosclerotic and antihypertensive qualities to its anticancer, immunomodulatory, antifungal, and digestive effects
Impact of Counseling on Patient Education and Dietary in Quality of Lifestyle and Nutritional Anemia in Diabetes Mellitus Patient: A Case-Control Study
Authors: Bhandari Shweta , Garg Vishal , Dwivedi Sumeet
Published: January 2024

The study’s goal was to see how w education and dietary guidance improved the quality of lifestyle and nutritional anemia in people with diabetes type 2. This 6 month prospective study was conducted in a hospital in Jaipur, Rajasthan. The demographic information (age, gender, social position, and economic status) was gathered using a form HRQoL after gaining the patient’s assent. In the intervention group n is 21 and also in the control group n is 21 so the total; patient was chosen 42. The baseline Hb and health-related quality score were taken in consideration in 1, 2 and baseline visits in a month-long study as a part of the design. Each visit concluded with the measurement of the hemoglobin level and health-related quality of life scores for both the intervention and control groups. The intervention group’s Hblevel changed significantly more than the control group’s after the nutrition education intervention finished [0.56–0.40 vs. 0.16–0.82 gm/dl, p = 0.002]. In contrast to the control group, where the mean increase in general health from baseline to second follow-up was statistically insignificant, the intervention group’s mean increase in general health from baseline to second follow-up was found to be significant as from the result obtained. Thus, nutrition education was found to be substantially linked to higher Hb levels, better dietary consumption, and improved health-related quality.mmune inflammatory illness distinguished by inflammation of hands, knees, wrists, and feet, causing bone and cartilage degradation, joint deformity, and muscle atrophy and thus movement limitations. Inflammatory mediators like necrosis factor and interleukins along with other inflammatory cytokines, execute a vital role in the initiation and advancement of rheumatoid arthritis (RA) as well as muscle atrophy. Existing literature discusses extensively the RA condition. However, the muscle atrophy related to this condition has received little attention, despite the substantial role of muscle atrophy in morbidity caused by RA. The review aims to highlight the relationship between muscle atrophy and RA, the mechanisms of muscle atrophy in RA and the association between oxidative stress and muscle atrophy in RA. This review will be useful for getting insights into the etiopathogenesis of muscle atrophy brought on by rheumatoid arthritis and available treatment alternatives for RA and muscle atrophy caused by RA. Discussion on the potential therapeutic targets and agents to treat skeletal muscle atrophy will help advance the knowledge to improve the condition of muscle atrophy associated with RA.
Online physiology teaching for nursing students during the COVID-19 pandemic – strengths, challenges and reinforcement measures
Authors: D Savitha , Kumar Susan , Anto Taniya
Published: January 2024

Objectives:

The forced shift to online education during the COVID-19 pandemic posed several challenges to Indian nursing education, especially with a complex subject like physiology. The objective of the study was to assess the apprehensions, expectations, and challenges perceived by nursing students and physiology faculty about the online mode of learning physiology, to evaluate the utility of reinforcement measures during the constraints of the pandemic, and to compare the online, offline, and blended modes.

Materials and Methods:

First-year nursing students (n = 100) underwent online and blended modes of physiology learning, with added reinforcement measures, during the pandemic. Beginning, mid, and end of course feedback was taken from students on the expectations and perceptions of the online mode. Feedback was obtained from students and faculty to understand the strengths and challenges of both modes. Quantitative data of student feedback were analysed using the Cochran-Mantel-Haenszel test. Thematic content analysis was used for qualitative data. Objective measures of student performance were compared using unpaired t-tests.

Results:

Online learning was perceived to be more difficult than anticipated by students. ‘Comfort’ in learning and ‘time management’ were the major strengths, while ‘reduced internet connectivity,’ ‘lack of interactions’ and ‘health issues’ were the biggest challenges expressed by students and faculty. The planned reinforcement measures were ‘sometimes’ helpful in revising and improving students’ confidence. The final summative assessment scores of students showed a better performance compared to the preceding academic batch.

Conclusion:

Students and faculty expressed some advantages and several disadvantages of online learning. They preferred offline or well-designed blended learning. The reinforcement measures seemed to aid student learning. The objective measures of assessment showed that students adapted well to the online mode. A model for blended learning for 1st-year nursing education, that utilises the advantages of both modes of learning, has been proposed, which requires further validation.
Analisis Penerapan Akuntansi Pesantren Berdasarkan ISAK 35 pada Pondok Pesantren Modern I’aanatuth Thalibiin Perawang
Authors: Nanda Suryadi  , Arie Yusnelly  , Muhammad Arif  , Ryla Lidia Susanti
Published: January 2024

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana akuntansi pesantren yang diterapkan Pondok Pesantren Modern I’aanatuth Thalibiin. Selain itu juga untuk mengetahui bagaimana faktor yang mempengaruhi, kendala yang dihadapi serta memberikan solusi dari kendala yang dihadapi dalam penerapan ISAK 35 pada Ponpes Modern I’aanatuth Thalibiin. Metode yang diterapkan pada penelitian ini adalah metode kualitatif deskriptif dengan sumber data primer dan sekunder yang diperoleh dari observasi, wawancara, dokumentasi dan studi pustaka. Adapun metode analisis data dilakukan dengan pengumpulan data, reduksi data, penyajian data, serta penarikan kesimpulan. Hasil penelitian yang diperoleh menunjukkan bahwa laporan keuangan Pondok Pesantren Modern I’aanatuth Thalibiin belum sepenuhnya sesuai dengan prinsip-prinsip yang berlaku umum di dalam akuntansi syariah dan belum sesuai dengan ISAK 35. Adapun yang menjadi limitasi dalam penelitian ini terletak pada ruang lingkup penelitian hanya pada satu pondok pesantren dan metode analisis yang sederhana.
Pre-Operative Pain’- A Clinical Indicator to Govern the Choice of Pulpotomy Agent in Primary Teeth: A Retrospective Study
Authors:   The University of Lahore, Babar Palwasha , Naeem Siddique Saqib , Zalan Abul Khair , Ilyas Zainab , Munir Sidra , Gul Anika
Published: January 2024

OBJECTIVE: To evaluate the effect of pre-operative pain on the success of pulpotomy in primary teeth and to assess whether formocresol (FC) or MTA performs better in patients with pre-operative pain. METHODOLOGY: Data was collected retrospectively from the records of Department of Pediatric Dentistry, Children Hospital, Islamabad. Only patients with complete pre-operative and one-year follow-up clinical and radiographic records were included. A total of 60 teeth were selected for the study on which pulpotomy was performed. Among the selected teeth, thirty teeth were symptomatic at time of treatment and thirty were asymptomatic. Fifteen teeth in each group were treated with FC and fifteen with MTA as pulpotomy medicament. RESULTS: After one-year, the clinical and radiographic success of pulpotomized teeth with positive history of pain was found to be 70% and 53.3% respectively. Among the teeth with positive pre-operative pain, 60% of the teeth treated with FC and 80% of the teeth treated with MTA showed clinical success. The radiographic success rate was found to be 33.3% and 73.3% for FC and MTA respectively. CONCLUSION: The results from the current study suggest the presence of pre-operative pain negatively affects the success of pulpotomy in primary molars and could be used as an important clinical indicator to govern the choice of pulpotomy agent in clinical practice. KEYWORDS: Pulpotomy, Formocresol, Mineral trioxide aggregate, Primary teeth.
Comparison of Powered Toothbrushes and Manual Toothbrushes in Removing Dental Plaque among Children with hearing Disabilities: A Randomized Pilot Study
Authors:   Islamic International Dental Hospital, Riphah University, Islamabad, Hassan Sobia Hassan , Zahid Anam , Khalil Beenish , Hasan Maryam , Nazami Arooba
Published: January 2024

OBJECTIVE: This study aimed to compare the the effectiveness of plaque removal between manual and powered toothbrushes in hearing impaired children. Maintaining a good quality of life requires optimal levels of oral hygiene. In differently abled subjects, manual dexterity may be slightly compromised, which is why powered toothbrushes were initially designed to help overcome the slight deficit. METHODOLOGY: A parallel arm, randomized study was conducted. Twenty two congenitally hearing-impaired participants aged eighteen to twenty two of age were recruited from National Special Education Centre for Hearing Impaired Children,Islamabad. They were randomly divided into two groups of eleven participants. Plaque levels were evaluated on the first day and plaque removal effectiveness of powered toothbrushes compared with manual toothbrush was checked on the eighth day. Plaque scores were evaluated using the simplified Oral Hygiene Index and Turesky's Modification of Quigley Hein Plaque Index. RESULTS: No significant difference of Mean score in effectiveness of plaque removal between manual and powered toothbrushes was seen. CONCLUSIONS: Manual and powered toothbrushes are equally effective at plaque . More studies highlighting cost effectiveness and patient's perception regarding ease of use are required to confirm results. KEYWORDS: Differently abled patients, manual toothbrushes, electric toothbrushes, oral hygiene.
Factors Influencing the Emergence of Antimicrobial Drug Resistance in Clinical Dental Practice
Authors:   Islamabad Medical and Dental College, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Hafeez Resham , Mahmood Hina , Raza Fahad , Jabeen Wajeeha , Hyder Pakiza Raza
Published: January 2024

OBJECTIVE: To investigate the perception of general dentists regarding the over-prescription of antibiotics leading to Antimicrobial drug resistance in their clinical practice. METHODOLOGY: A cross-sectional study encompassing a personalized Likert scale questionnaire on factors influencing anti-microbial resistance in dental general practices was conducted on 196 practitioners. The questionnaire inquired about different factors which tend to affect the over-prescription of antibiotics and influence anti-microbial resistance. It was piloted on 30 participants before dissemination. RESULTS: Factors showing the highest level of agreement were "lack of patient awareness regarding use of antibiotics" (96.9%), "over-the-counter availability" (95.4%), and self-medication" (95.4%). General dental practitioners were overprescribing in their clinical setup due to improper guidelines (24.4%), for their patient's satisfaction (21.2%), and lack of knowledge (19.2%).33.5% of them stated that patients reporting to them were self-medicating and 27.2% found that their patients had a lack of awareness. CONCLUSIONS: This study concluded that all the factors were responsible for the Antimicrobial Drug Resistance phenomenon in clinical dental practice. However, the majority of the dentists were over-prescribing antibiotics due to improper guidelines, lack of knowledge, and for the patient's satisfaction. KEYWORDS: Antimicrobial Drug Resistance; Awareness; Antibiotics; Dental General Practices; Over-the-Counter Drugs.
Studi Pendahuluan Potensi Carbon Capture Storage (CCS) Melalui Identifikasi Sumber Emisi CO2 beserta tinjauan geologi di Daerah Probolinggo, Jember, dan Bondowoso, Jawa Timur
Authors: Sari Riska Laksmita , Haeruddin Haeruddin
Published: January 2024

Carbon dioxide (CO2) is a gas compound that causes the greenhouse effect. The majority of carbon dioxide gas production is dominated by large industrial industries such as Coal Steam Power Plants (PLTU), the cement industry and fossil fuel motorized vehicles (Hydrocarbons). Several technologies have been implemented and developed, in an effort to reduce the negative impact of CO2 accumulation on the earth's surface. One of them which is currently a topical topic is Carbon Capture Storage (CCS). CCS is a storage system used to receive and store carbon releases from industry and power plants into geological formations safely and permanently with a certain capacity for a long period of time. CCS is seen as a very efficient method because it can balance achieving net zero emissions while maintaining energy security. In this research, a preliminary study was carried out in the initial step of identifying potential sources of CO2 emissions along with a review of geology as a potential CO2 storage. In the Probolinggo, Jember and Bondowoso areas. From the identification results, it was concluded that the Paiton PLTU area in Probolinggo has the largest potential for CO2 production, around 1.98 million tons/year. The grological scope of the Paiton PLTU area meets one of the CO2 Storage criteria because the formation is included in the East Kendeng sedimentary zone. However, further studies need to be carried out to validate the potential for CO2 storage in further geological, petrophysical and fault analysis
Pengomposan Sampah Organik di TPA Air Dingin Kota Padang: Potensi Ekonomi dan Manfaat Lingkungan
Authors: Fauzy Resti Prima , Sawir Hendri , Fitrada Wathri
Published: January 2024

Kota Padang adalah salah satu kota yang memiliki pertumbuhan populasi dan aktivitas masyarakat yang cukup tinggi. Hal ini menyebabkan jumlah timbulan sampah meningkat dan TPA Air Dingin Kota Padang diprediksi penuh sebelum waktunya. Penelitian ini bertujuan untuk mengkaji potensi ekonomi dari produksi dan pemanfaatan kompos di Tempat Pemrosesan Akhir (TPA) Air dingin Kota Padang. Metode penelitian yang digunakan adalah studi lapangan dan wawancara serta studi literatur untuk pengumpulan data primer dan sekunder. Setelah itu data di analisis untuk evaluasi, analisis pasar, dan analisis pendapatan. Hasil penelitian menunjukkan bahwa kegiatan pengurangan sampah di TPA Air Dingin Kota Padang dilakukan dengan cara pengomposan. Proses ini dimulai dari masuknya sampah ke TPA, penimbangan, penyortiran, pengomposan, pengemasan dan pemanfaatan. Luas lahan yang dibutuhkan untuk sampah organik sebesar 20 ton/hari yaitu sekitar 1200 m2. Jika kompos yang dihasilkan oleh TPA dijual belikan maka didapatkan penjualan 5 – 36 juta rupiah/bulannya. Pendapatan ini dapat digunakan untuk meningkatkan infrastruktur dan layanan di TPA, termasuk dalam bidang pengelolaan sampah yang lebih berkelanjutan.
Pengolahan Limbah Cair Rumah Makan Dengan Constructed Wetlands Skala Rumah Tangga
Authors: Ananta Muhammad Andre , Suciana Indah , Izwara Yarra , Apriani Isna
Published: January 2024

Wastewater from restaurants has a high organic content. Wastewater must be processed until it conforms with the effluent standard before being disposed of in water. Construction of subsurface wetland is one of the treatment options. This study made use of a reactor that Kiambang and Melati Air had planted. Sedimentation basin, wetland basin, and treatment basin are the three reservoirs used in this study. The wastewater was a sedimented effluent from restaurant operations. Seeding, acclimation, and running are the processes used. running for seven days. The variables under test were pH, TSS, and BOD (biological oxygen demand). Before treatment, the concentration is BOD 546,75 mg/l, TSS 340 mg/l, and pH 7,24. After treatment, the concentration is BOD 30,75 mg/l, TSS 95 mg/l, and pH 7,42. As a result, BOD has an efficiency of 94,376% and TSS has an efficiency of 72%. The concentrations of TSS did not meet the set quality criteria, although the levels of BOD and pH did.