bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Short-Term Prognostic Factors of Posterior Single Open-Door Laminoplasty in Patients with Cervical Spondylotic Myelopathy
Authors: Sun Yi , Ye Jun , Qiu Junjie
Published: December 2024

AIM: Posterior cervical expansive open-door laminoplasty (ELAP) is one of the main methods for the treatment of multilevel cervical spondylotic myelopathy (CSM). However, some patients are vulnerable to developing complications such as kyphosis and axial symptoms after ELAP, potentially facing adverse prognosis following the procedure. At present, there are few reports on the short-term prognostic factors in Chinese patients with CSM after undergoing ELAP. The main objectives of this study are to investigate the efficacy of ELAP in the treatment of CSM and to analyze the short-term prognostic factors. 
METHODS: This study is a retrospective study. A total of 98 patients with CSM who received ELAP surgery in The First People's Hospital of Tongxiang City from May 2021 to October 2022 were selected as the study participants. The clinical efficacy of the ELAP was evaluated using visual analog scale (VAS), Japanese Orthopedic Association (JOA) score, and assessments based on imaging indicators. All patients were followed up for 1 year postoperatively. The short-term prognosis was analyzed according to JOA improvement rate, and the short-term prognostic factors were analyzed using multivariate logistic regression. 
RESULTS: The JOA scores of 98 CSM patients at 1 year after operation were significantly higher than those before operation (p < 0.001), and their postoperative VAS score were significantly lower than those before operation (p < 0.001). The postoperative cervical curvature (p < 0.001), sagittal diameter of cervical spinal canal (p < 0.001) and distance between vertebral body and posterior edge of spinal cord (p < 0.001) were significantly improved relative to the corresponding preoperative values. There was no significant difference in cervical 2–7 Cobb angle before and after operation (p = 0.979). Multivariate logistic regression analysis showed that age (p < 0.001), course of disease (p < 0.001) and preoperative JOA score (p < 0.001) were independent risk factors affecting the short-term prognosis in CSM patients. 
CONCLUSIONS: ELAP is a safe and effective therapeutic approach for CSM, whose short-term prognosis is related to age, course of disease and preoperative JOA score.
Efficacy of Percutaneous Kyphoplasty and Percutaneous Pedicle Screw Fixation in Managing Osteoporotic Vertebral Compression Fractures in Middle-Aged and Elderly Individuals: A Comparative Study
Authors: Li Jun , Zhou Wenbin , Cai Danyu , Chen Jiansheng , Tao Xian
Published: December 2024

AIM: This study is aims to compare the clinical efficacy and safety of percutaneous kyphoplasty (PKP) and percutaneous pedicle screw fixation (PPSF) in managing osteoporotic vertebral compression fractures (OVCFs) among middle-aged and elderly individuals. 
METHODS: A total of 142 patients aged 55–65 years were selected retrospectively from the Department of Orthopedics of our hospital from June 2021 to June 2023 and classified into PKP (n = 68) and PPSF (n = 74) groups. General data of patients were collected, and related perioperative indicators, Visual Analog Scale (VAS) scores, Oswestry Disability Index (ODI), Activities of Daily Living (ADL) scores, changes in Cobb angle of the fractured vertebrae, vertebral compression rate, as well as postoperative complications were compared between the two groups. 
RESULTS: The PKP group showed shorter operation duration, reduced intraoperative blood loss, shorter hospital stay, and earlier compared to the PPSF group (p < 0.001). In comparison with the PPSF group, the PKP group endured much reduced pain, with improvements in spinal function and quality of life. On postoperative day 1, the PPSF group demonstrated superior restoration of vertebral height and deformity correction in relative to the other group (p < 0.05), with no significant difference in preoperative Cobb angle and vertebral compression rate (p > 0.05). The incidence of complications showed no significant differences between the two groups (p > 0.05). 
CONCLUSIONS: The advantages of PKP lie in its ability to effectively relieve pain, improve spinal function, and enhance the quality of life. PPSF, meanwhile, is well-suited for the recovery of vertebral height and the correction of deformity in the early stage.
Application of Comfort Nursing Based on Evidence-based Concept in Radial Artery Puncture Hemostasis of Patients after Coronary Intervention
Authors: Fan Jianli , Han Xiaoxue , Zhu Haixiang
Published: December 2024

AIM: This study aimed to explore the application effect of comfort nursing based on evidence-based concept in radial artery puncture hemostasis of patients after coronary intervention. 
METHODS: This interventional study included the clinical data of 180 patients who underwent percutaneous radial coronary intervention in Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, from July 2024 to September 2024. All patients were treated with radial artery hemostasis device after operation. Patients were divided into two groups based on the single and even number of admission date. Patients admitted with single number were included in the control group (routine nursing, n = 94), and patients admitted with even number were included in the study group (comfort nursing based on evidence-based concept, n = 86). The post-surgical discomfort, postoperative complications, and patient satisfaction levels were comparatively analyzed between the two experimental groups. 
RESULTS: The hemostasis was successfully achieved in both groups of patients, with a success rate of 100%. Compared to the control group, visual analogue scale (VAS) scores were significantly reduced in the study group at 2 and 4 hours after the procedure (p < 0.05). Post-surgery, the study group experienced reduced rates of subcutaneous ecchymosis, swelling of palms and forearms, and reduced complication rate compared to the control group (p < 0.05). Furthermore, patients in the study group exhibited higher mission content, service attitude, nursing quality, nursing approach score, and nursing satisfaction score than those in the control group, and the differences between the two groups were statistically significant (p < 0.001). 
CONCLUSIONS: Using comfort nursing based on the evidence-based concept during radial artery puncture hemostasis in patients after the coronary intervention effectively relieves patients' pain, reduces postoperative complications and improves nursing care satisfaction. 
CLINICAL TRIAL REGISTRATION: China Clinical Trial Registry: ChiCTR2400087080.
ПОЭТИКА ЖЕСТА В РАССКАЗЕ Л.Н. ТОЛСТОГО «ТРИ СМЕРТИ»
Authors: Абдуллина Лилия , Гайфуллина Миляуша , Сулейманова Фания
Published: December 2024

In Tolstoy's poetics, natural bodily manifestations of a person are not just a kind of «lie meter» or an indicator of the level of correspondence of the "external" to the "internal" in the communication process, but a kind of way of recognizing human essence. In this study, it is important to identify the characterological function of the gesture of the characters in the story "Three Deaths" by L.N. Tolstoy, therefore, in this work, the "gesture" is understood as a sufficiently impulsive manifestation, possessing non-directionality and some involuntary expression.
In the story, man and nature find themselves in the same row as carriers of living life. But if a person moves away from nature and separates himself from the "universal everything", then naturalness is erased in him – the harmony of the "inner" and "outer". Therefore, the attempts of the heroes of the story (the lady, her husband, the doctor) to hide their inner feelings are doomed to struggle with their own body, which is characterized by absolute sincerity. Description of the external appearance of the characters – portrait characteristics, gesture, facial expressions – a kind of "lie meter", a means of exposing the hidden "inner". Inadequate external manifestations carry the truth about a person.
The materials of the article can be used in the practice of teaching historical and literary and theoretical literature courses at the university, as well as Russian literature in educational institutions of various levels.
ҚАЗАҚ ЖАЗУ ТЕОРИЯСЫНЫҢ ӨЗЕКТІ МӘСЕЛЕЛЕРІ
Authors: Қалыбаева Қаламқас
Published: December 2024

The scientific debates of linguists on the issue of translating the Kazakh script into Latin created a wonderful opportunity to correctly assess the errors and shortcomings of our national theory of writing. Thanks to this, Kazakh scientists got an opportunity to look back and see where they made a mistake in the theory of Kazakh writing. As a result, we saw that the theory of Kazakh writing, developed by Akhmet Baitursynuly, was repressed together with its author. That is, today's Kazakh writing is deliberately deviated from the real theory of national writing, formed by Akhmet. Today's terror of literacy has absorbed the dangers of those days of Soviet repression, it is intertwined with those dangerous days, according to Ahmet, it is "like the legs of a Chinese girl", tied with a rope to fit into the theory of Russian literacy. The article deals with a number of such unresolved problems of Kazakh writing from a historical point of view.
АЛТЫН ОРДА -ҚЫПШАҚ ДӘУІРІ ЖАЗБА МҰРАЛАРЫНДАҒЫ ҒАЛАМНЫҢ КОНЦЕПТУАЛДЫ МОДЕЛІ
Authors: Сабыр Мұрат , Ержигитова Гульден , Бөкенбай Ерасыл
Published: December 2024

The paper examines the written monuments of the Middle Ages as a coherent linguistic heritage. Based on a comprehensive study of the language of written monuments, their consonance with the spiritual culture of the Kazakhs is shown. An attempt is made to reveal the linguistic picture of the world through linguistic phenomena based on the ideological community of the ancient Kipchak culture and modern Kazakh culture, identifying language and ethnicity as a single whole. To achieve this goal, an ethnocultural analysis of phraseological units as keepers and bearers of the linguistic picture of the world is made.
Specific data substantiates the ability of stable phrases in the language of written monuments to convey cultural information about the national mentality. This indicates the unity, community and integrity of the language with the worldview and worldview, the cultural tradition of the Kazakhs, which begins upon from the origins of time.
СЕМАНТИЧЕСКОЕ ПРОСТРАНСТВО КОНЦЕПТА «ҠУНАҠ/ҚОНАҚ» (ГОСТЬ) В БАШКИРСКОЙ И КАЗАХСКОЙ ЯЗЫКОВОЙ КАРТИНЕ МИРА
Authors: Самситова Луиза
Published: December 2024

The article examines the semantic space of the concept "unak/onak" (guest) in the Bashkir and Kazakh language picture of the world, which is represented by lexical units of language that determine culture, mentality, life, psychology, traditions, customs of the Bashkirs and Kazakhs. The nuclear zone of the "guest" concept is made up of language units expressing hospitality, respect for the owner, honoring the guest, etc. The periphery of the concept of "guest" includes Bashkir and Kazakh folk proverbs and sayings, phraseological units, names of Bashkir and Kazakh national dishes, rituals, holidays, traditions, etc. The author comes to the conclusion that the concept of "guest," being a fragment of the language picture of the world, is a complex, multi-layered mental education, which is of high importance for the Bashkir and Kazakh culture, since it expresses universal and specific aspects of the formation of the socio-cultural sphere of human existence. The linguistic expression of the concept of "guest" in the Bashkir and Kazakh languages ​ ​ is characterized by a variety of speech units, proverbs and sayings, phraseological means of representing the culture of hospitality (meeting, receiving, eating, seeing off guests, etc.). The national-cultural specificity of the implementation of the concept of "guest" in the Bashkir and Kazakh linguistic consciousness is due to the peculiarities of the national character, namely: benevolence, kindness, cordiality, sincerity, etc.
MODERN APPROACHES IN TEACHING ENGLISH LANGUAGE
Authors: Makasheva Farida , Faizullieva Akmarzhan , Urazova Alima , Suyunova Aigerim , Ishangaliyeva Kamila
Published: December 2024

The main goal of teaching foreign languages is to train students to freely navigate a foreign language environment and to respond appropriately in various situations, that is, to communicate. Every language reflects the culture of the people who speak it. The task of the modern teacher is to create conditions for each student to improve their command of the language, to select teaching methods that allow each student to express their enthusiasm and creativity, and to stimulate cognitive activity during the foreign language acquisition process. Therefore, one of the main objectives is to cultivate an interest in this subject and strive to awaken the students’ creative and intellectual abilities.
The aim of this article is to examine modern approaches, particularly those with a communicative focus, to designing English language lessons and to discuss their practical application.
The theoretical significance of the research lies in the comprehensive review of modern methods of foreign language teaching and in the theoretical substantiation of pedagogical conditions for applying modern technologies in the teaching process.
The practical significance of the research is that the theoretical principles can be actively used in the process of teaching foreign languages in general education schools. Additionally, this research explores conditions for effective use of modern pedagogical methods and developmental techniques. The introduction of modern technologies creates prerequisites for intensifying the educational process. They facilitate the shift from mechanical knowledge acquisition to mastering the skill of independently acquiring new knowledge. Modern technologies contribute to the development, preservation, and enhancement of students’ personal qualities.
ANALYSIS OF MODERN ASPECTS OF CORROSION PROBLEMS AND THEIR SOLUTIONS
Authors: Gubaidullina Gulkhan , Kenzhebekova Shyryn , Niyazbekova Aktoty
Published: December 2024

The article presents a study of technogenic phosphoride raw materials obtained in Kazakhstan as waste from various industrial processes in order to be used as raw materials for the production of corrosion inhibitors in the oil and gas industry. The chemical composition and physical properties of phosphoride raw materials from various sources were studied, methods of its enrichment were analyzed, and studies were also carried out to change the obtained phosphate compounds in order to increase their effectiveness as corrosion inhibitors. Laboratory tests were carried out on steel samples typical for the oil and gas industry and optimal conditions for the use of synthesized inhibitors were determined. The results of the study show that technogenic phosphoride raw materials can be effectively used for the production of corrosion inhibitors, which will reduce raw material costs and contribute to the sustainable development of the oil and gas industry in Kazakhstan. The article also considers the possibility of modifying the obtained inhibitors in order to improve their properties and expand the scope of application.
Metal corrosion is a serious problem that can lead to significant economic losses and pose a safety risk. Phosphorus inhibitors are an effective corrosion prevention tool used in various industries, including oil and gas, energy, chemical and others. This article is devoted to the study of the effectiveness of phosphate inhibitors of corrosion, describes modern approaches to their study and prospects for further development. Particular attention is paid to the environmental benefits of inhibitors developed based on the processing of man-made raw materials, which contribute to reducing the volume of waste and reducing the environmental burden on nature. The development of inhibitors based on the processing of man-made waste will create a new eco-oriented strategy in the oil and gas industry of Kazakhstan, combining economic efficiency with respect for the environment.
ОСИММЕТРИЯЛЫҚ ҚАБЫҚШАЛАРДАҒЫ КЕРНЕУЛЕРДІ МОМЕНТСIЗ ТЕОРИЯ БОЙЫНША АНЫҚТАУ
Authors: Киікбаев Манас , Аманжолов Айбар
Published: December 2024

In the Republic of Kazakhstan, a significant number of tanks are used for operations for the collection and storage of oil and oil products. The design of the tank is a vertical steel tank manufactured using roll or sheet assembly technology. Despite the longer use of the technology for the manufacture of such tanks, the risk of weld defects remains quite high.
High voltage level, non-compliance with the technology and manufacturing mode during construction significantly affect the technological properties of the connection.
Thin-walled shell theory is used to calculate steel tanks with wall and bottom elements of various thicknesses. Shells according to the shape of the axial section are divided into cylindrical, conical, spherical and drip structures.
In this case, the use of the theory of wall instantaneous shells for the calculation of tanks should have features that take into account their design and operational features.
The work provides for the use of the theory of unobstructed shells to study the stressed-deformed side of thin-walled shells of the tank wall.
Pendampingan Pemanfaatan Akuaponik untuk Kemandirian Ekonomi di Masyarakat Kampung Besaran
Authors: Romadloni Sahru Romadloni , Koneksia ST. Oik Koneksia , Azizah Nur Azizah
Published: December 2024

Program Pengabidan dilakukan untuk implementasi teknologi akuaponik sebagai solusi efisien untuk meningkatkan produksi sayuran dan ikan dalam lingkungan yang terbatas. Akuaponik mengintegrasikan budidaya ikan dan tanaman dalam satu sistem, menggunakan limbah ikan sebagai nutrisi tanaman. Kegiatan ini dilakukan di Kampung Besaran, Dusun Kaliselogiri, dengan tujuan meningkatkan keterampilan masyarakat dalam memanfaatkan lahan pekarangan untuk budidaya pangan. Hasil implementasi menunjukkan pertumbuhan yang baik pada ikan lele dan kangkung, serta potensi besar akuaponik dalam menghemat air hingga 90% dibandingkan metode pertanian konvensional. Teknologi ini tidak hanya mendukung kesehatan masyarakat melalui konsumsi pangan yang lebih aman, tetapi juga berpotensi meningkatkan kesejahteraan melalui pendekatan pertanian yang berkelanjutan dan hemat ruang.
The vocal membranes may explain why humans are so talkative
Authors:   Ritsumeikan University, Tokuda Isao
Published: December 2024

Humans are talkative animals. We enjoy chatting with family, friends, and colleagues over daily happenings. Verbal communication is one of the major means to express ourselves. Turning to the animal kingdom, animals also use acoustic cues for their communication. We see dogs bark and cats meow to communicate with their owners. Birds sing to mark their territory or attract mates. However, their vocal repertoires are not as extensive as humans. Chimpanzees are the closest phylogenetic relative of humans and are well known for their complex societies and highly developed cognitive abilities. Nonetheless, they might be considered taciturn if they are put in a human society.
Research on the Design of Digital Virtual Display Space for the haihun Marquis Chariot and Horses Based on Multidimensional Interaction Technology
Authors: Dai Yijun , Yi Fengyu
Published: December 2024

This research employs qualitative descriptive analysis to explore the display needs of the Han Dynasty haihun Marquis tomb's chariot and horse relics in Nanchang. It investigates how the design of a chariot-and-horse-style digital virtual exhibition hall, leveraging digital media technologies, can present the historical stories behind these artifacts. The aim is to create a new online virtual exhibition experience that effectively promotes the integration and development of the cultural and tourism industries. Ultimately, it seeks to achieve a win-win fusion of cultural and economic innovation by merging online virtual spaces with historical culture.
The Role of Universities in Promoting Social Responsibility (Universities of Amman as a Study Samples)
Authors: Alsharo Sahar yousef abed elkarem , Al-Thani Mona Jabor M J
Published: December 2024

This study aimed to identify the role of universities in Amman in promoting social responsibility by understanding the responsibility of faculty members in universities and its relationship to their job performance from the students' point of view. The descriptive correlational approach was used, which included the use of a questionnaire consisting of 229 male and female students out of a total of 77,213 male and female students, with two main axes, the first axis measures the social responsibility of faculty members, and the second axis measures their job performance. The results of the study showed that the degree of social responsibility of faculty members in those universities was high from the students' point of view. The results also revealed the existence of statistically significant differences in the social responsibility scale attributed to the variable of university type, specifically in favor of private universities. In addition, the results showed that the degree of job performance of faculty members from the students' point of view was high.
Tabaquismo en Costa Rica. Impacto persistente y nuevos desafíos
Authors: Bejarano-Orozco Julio
Published: December 2024

Costa Rica es un país que desde hace varios lustros exhibe una disminución sostenida en la tasa de tabaquismo. Sin embargo, los problemas sanitarios y sociales, así como los costos asociados a estos, son de grandes proporciones e imponen una pesada carga al Estado. Es, por tanto, una nación con niveles de consumo comparativamente reducidos, pero con condiciones de riesgo cuya atención es impostergable.
Este trabajo revisa algunos aspectos centrales de la epidemiología del tabaquismo en los últimos 30 años y analiza la disminución indicada. La baja en la tasa de consumo actual se refleja tanto en la población adulta como adolescente. Sin embargo, en esta última existen varios desafíos por atender, en especial en lo que se refiere a las personas susceptibles y su potencial para ser fumadores en el futuro.
Se explora, además, la temática de los cigarrillos electrónicos y las consecuencias que su utilización está revelando en distintos contextos, así como las implicaciones de la relación entre el tabaquismo y la enfermedad COVID-19.
Cromoblastomicosis: características clínicas y microbiológicas
Authors: Badilla Ramírez Yanán , Madrigal Zúñiga Kattia , Lara Campos Pablo
Published: December 2024

La cromoblastomicosis es una infección micótica crónica, causada por la inoculación traumática de algún tipo de hongo dematiáceo saprófito que habita en el suelo, las flores, la vegetación y la madera. Esta enfermedad constituye la segunda micosis subcutánea más frecuente en Costa Rica y afecta principalmente a hombres entre 30 y 60 años. En general, esta enfermedad compromete tejido cutáneo y subcutáneo, especialmente en extremidades inferiores y superiores, y se asocia a factores ocupacionales, relacionándose más con personas dedicadas a la agricultura y otras similares. Entre sus características se encuentra el desarrollo de lesiones granulomatosas de lenta evolución, que con el tiempo pueden producir hiperplasia de tejidos epidérmicos. El diagnóstico se realiza mediante un raspado de las lesiones de la piel afectada, que se analiza en el laboratorio clínico mediante examen directo (microscopía de luz) y cultivo micológico. En lo que respecta al tratamiento, este aún no está bien definido ni existe un esquema farmacológico estandarizado; sin embargo, la mayoría de los reportes refieren éxito al aplicar una terapia combinada de terbinafina con itraconazol. Para conocer más sobre esta enfermedad y su forma de presentación, de manera tal que permita hacer un diagnóstico más oportuno, se describe un caso de cromoblastomicosis por Curvularia lunata detectado en Costa Rica.
La innovación del sector público en salud: ¿y ahora qué?
Authors: Castillo Peña Karol Dayanna
Published: December 2024

El uso de innovaciones en el sector salud ha retomado fuerzas en los últimos años, debido a la presencia de nuevos retos a corto y a mediano plazo. En este contexto, es necesario generar nuevos modelos de negocios que superen los esquemas tradicionales y compitan contra estos desafíos. Para lograr esto, las organizaciones deben dirigir todos sus esfuerzos hacia la transformación creativa de sus empleados, buscando obtener de ellos una capacidad estratégica que se refleje en innovaciones en los productos, servicios y modelos de negocio que desarrollen.
Propuestas para enfrentar el desafío de los tiempos y listas de espera en el Seguro de Salud
Authors: Arce Ramírez Claudio Arturo
Published: December 2024

El presente artículo trata una problemática central en el sistema de salud y para la sociedad, a saber, los tiempos y listas de espera. Para abordar este tema, se desarrollan en primera instancia elementos conceptuales relacionados con este fenómeno; seguidamente, se repasan de manera rápida algunas lecciones internacionales; y, por último, se brindan cuatro propuestas para enfrentar dicha problemática.
Normas de Publicación - Carta de Solicitud - Declaración Jurada de Originalidad
Authors: Cubillo Escalante Irene María
Published: December 2024

Normas de Publicación - Carta de Solicitud - Declaración Jurada de Originalidad
Fortalecendo a agricultura familiar para a segurança alimentar e o desenvolvimento sustentável
Authors: Kieling Daniel
Published: December 2024

A agricultura familiar é um componente crucial para a segurança alimentar e o desenvolvimento sustentável, representando uma parcela significativa da produção de alimentos no Brasil. Este estudo analisa os principais desafios enfrentados por esse setor, destacando a necessidade de estratégias que envolvam políticas públicas adequadas, financiamento acessível e adoção de tecnologias inovadoras. A pesquisa foi realizada em Ponta Porã, MS, que possui uma área de aproximadamente 5.328 km² e uma população de 93.937 habitantes. Foram utilizadas entrevistas com agricultores e especialistas da região, complementadas por uma revisão de literatura. Os resultados indicam que, quando bem apoiada, a agricultura familiar pode garantir maior segurança alimentar, promover a sustentabilidade ambiental e reduzir o êxodo rural. Conclui-se que políticas públicas eficientes, acesso facilitado ao crédito e uso de tecnologias modernas são fundamentais para a prosperidade da agricultura familiar.
Carbúnculo sintomático em bovinos
Authors: Bezerra Spinelli Eron
Published: December 2024

O carbúnculo sintomático, também conhecido popularmente como “Peste da Manqueira” ou “Mal do Ano”, é uma enfermidade economicamente importante e de difícil tratamento. É uma inflamação clostridial dos músculos esqueléticos, causada pelo Clostridium chauvoei. Diversos fatores, como traumas, isquemias vasculares, intervenções cirúrgicas, tumores e outras infecções bacterianas aeróbias e anaeróbias, podem dar início a esta infecção. Sendo uma doença de rápida evolução, o carbúnculo sintomático apresenta uma taxa de mortalidade de quase 100%. Os animais acometidos pela doença manifestam alguns clínicos, tais como anorexia, depressão, hipertermia e claudicação, inchaço localizado, doloroso, que se torna frio e edematoso com crepitação à palpação. A confirmação do diagnóstico de campo pode ser feita por exame laboratorial de amostras teciduais. O método mais eficaz para o controle e prevenção do carbúnculo sintomático é por meio do programa de vacinação. O carbúnculo sintomático é responsável por causar inúmeras perdas na criação, principalmente em bovinos. Dessa forma, as medidas de controle e profilaxia, tais como vacinação e boas práticas de higiene, se fazem extremamente importantes para manter a sanidade do rebanho, visando reduzir os prejuízos e maximizar a produção pecuária, garantindo maior rentabilidade ao produtor. Esta revisão tem por objetivo explorar um pouco mais sobre o carbúnculo sintomático, sua etiologia, patogenia, sinais clínicos, métodos diagnósticos, forma de tratamento e seu controle e profilaxia.
Nutrient profile and heavy metals content of an exotic fish Hypostomus plecostomus in Bangladesh: Health risk assessment
Authors: Awal Md. Rabiul , Moniruzzaman Md. , Hossen Md. Nazmul , amin Al- , Said Md. Abu , Islam Md. Saiful , Rahman Md. Ashikur
Published: December 2024

The Suckermouth catfish (Hypostomus plecostomus) is a freshwater species found in Bangladesh that is included in the group of invasive species according to the guidelines of the Ministry of Fisheries and Livestock. The detrimental effects of Suckermouth catfish and possible ways to eradicate them are yet unknown, thus finding substitute foods for fisheries goods is necessary. Before Suckermouth catfish is utilized as a raw material for fish meals, a rigorous analysis of its nutritional value and heavy metal content is required. The results of the analysis of the moisture content, protein content, lipid content, ash content, and carbohydrate content of the muscles showed that the average content percentages were 64.55%, 20.65%, 1.21%, 1.92%, and 11.87%. Additionally, the average concentrations of heavy metals Cu, Zn, Pb, Cd, and Cr in the muscle tissue of Suckermouth catfish were found to be 0.56, 61.76, 0.14, 1.78, and 0.45. Cu, Pb, and Cr levels are below the maximum level of tolerance, in accordance with this study. Conversely, it turned out that the levels of Zn and Cd above the maximum acceptable limits. Of particular, the levels of Cd were found to be around 30-35 times higher compared to the maximum acceptable values, posing a health risk to humans. It is not recommended to utilize this fish as fish meal because its heavy metal concentration exceeds the maximum limit. This heavy metal can build in the body and be harmful if fish meal is made from this species.
CRISPR-dCas9-mediated CpG island editing: A potential game-changer for diabetes treatment
Authors: Dutta Khokon Kumar
Published: December 2024

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia. Current therapeutic strategies primarily manage symptoms, leaving a substantial unmet need for curative interventions. This review explores the potential of CRISPR-dCas9-mediated CpG island editing as a promising therapeutic approach for T2DM. CpG islands, DNA regions enriched in cytosine-guanine dinucleotides, play a pivotal role in gene regulation. Their methylation status significantly influences gene expression. By targeting specific CpG islands within genes involved in glucose metabolism and insulin signaling, CRISPR-dCas9 can modulate gene expression and restore metabolic homeostasis. A particular focus is placed on the TXNIP gene, implicated in T2D pathogenesis. Reprogramming TXNIP expression using CRISPR-dCas9 offers potential therapeutic benefits, including protecting pancreatic beta cells, enhancing insulin sensitivity, and mitigating inflammation. While the potential of CRISPR-dCas9-mediated CpG island editing is clear and evident now, further steps are imperative to translate this approach into effective and safe therapies for T2DM patients.
Are Genetically-Modified Foods Made for the Common Good? The Perspectives of the Victoria Islanders
Authors:   University of Washington, Seattle, United States, Omoyajowo Koleayo ,   University of Lagos, Akoka. Nigeria, Omoyajowo Kolawole ,   University of Washington, Seattle, United States, Akinola Adeyemi ,   Mountain Top University, Nigeria,   University of Lagos, Akoka. Nigeria, Ogunyebi Amos ,   University of Lagos, Akoka. Nigeria, Alao Rebecca ,   National Centre for Technology Management, Victoria Island, Nigeria, Makinde Oladapo ,   National Centre for Technology Management, Victoria Island, Nigeria, Orekoya Oluseye ,   National Centre for Technology Management, Victoria Island, Nigeria, Makengo Benjamin ,   University of Kinshasa, Kinshasa, Democratic Republic of the Congo, Akinola Olusegun ,   Babcock University, Nigeria, Jatau Sarah ,   Plateau State University, Bokkos, Nigeria, Ukoh Sandra ,   University of Lagos, Akoka. Nigeria, Raimi Morufu ,   Federal University Otuoke, Nigeria
Published: December 2024

This research investigated the depth of public knowledge on genetically modified food products, and further explored their understanding of the underlining socio-environmental and public health benefits of GM food products within the socio-demographic indices. To achieve this goal, 369 respondents were recruited through a convenience sampling method in Victoria Island, Lagos, Nigeria and data were gathered using a structured questionnaire. The target population for this study comprised "employed adults either residing or working" on Victoria Island, Lagos. The results showed that the majority of respondents (n=232, 62.9%) were knowledgeable about GM foods and their associated issues. However, many believed that people in their neighborhood or community were not well-informed on the topic. However, awareness on GM foods and associated concerns may be associated with sociodemographic factors such as marital status and education (P<0.01). The majority of respondents were well-informed and had an understanding of the environmental and health advantages of GM foods. In fact, about 61.8% believed that GM food production could sustainably decrease the reliance on chemical pesticides, fertilizers, and other energy inputs, along with their ecological impacts. Most respondents did not feel that purchasing or consuming GM foods conflicted with their beliefs or would affect their food choices. This study recommends that the government should actively educate the public on the ecological and health benefits of GM foods and address any safety concerns. Furthermore, the government should implement strict border controls and food labeling for GM products to safeguard consumer rights arising from the preference for the consumption of organic foods. Additionally, sufficient technical and financial assistance should be provided to farmers who subscribe to the organic seeds program for bolstering national food security.
VALIDAÇÃO DE UM INSTRUMENTO ORIENTADOR DE CONDUTAS PARA MANEJO DE CICATRIZES
Authors: Fonseca Anna Beatriz Lopes , Dias Bryan Matheus Lima , Mendonça Isadora Reis Eduardo de , Oliveira Juliana Almeida de , Dantas Lorena Gomes , Lima Matheus Macedo , Silva Taís Grisi Pessoa , Iglesias Victor Adorno , Costa Gustavo Nunes de Oliveira , Oliveira Francisco Felipe Góis de
Published: December 2024

Introduction: In clinical practice, it is important to validate a flowchart in order to systematize and guide better management of pathological scars. Despite the diversity of existing instruments to guide the prevention, treatment and follow-up of pathological scars, there is a need for a reproducible, feasible and functional instrument. Objective: Perform validation of an updated algorithm to guide the management of old hyperproliferative scars and recent trauma or surgery. Methods: For the current study, an algorithm was developed for scars that will be validated using the Delphi method, which will be composed of specialist plastic surgeons who will evaluate the respective instrument through a questionnaire, which gathers questions about the form and content of the flowchart proposed, applied in successive rounds in order to ensure a satisfactory convergence between professionals, however, in the evaluation of the questionnaire, a mandatory minimum agreement is necessary for the present study to be validated. Results: The questionnaire applied and answered by plastic surgeons on the guideline instrument allowed quantifying and classifying the global CVI as valid, which enabled the validation of the flowchart, even though two of the individual CVIs were invalid. Conclusion: In this work was validated a flowchart about old hyperproliferative scars, recent surgeries or traumas that can benefit the practice by better handling these conditions, providing the patient with good aesthetic results and less functional impairment.
FORMAÇÃO CONTINUADA DE PROFESSORES DO ENSINO FUNDAMENTAL PARA USO DE TDICS EMERGENTES NO ENSINO REMOTO: UM RELATO DE EXPERIÊNCIA DO ESTÁGIO SUPERVISIONADO EM COMPUTAÇÃO I
Authors: Oliveira Valcimar Terço de
Published: December 2024

The Use of Digital Technologies of Information and Communication (TDIC), had significant advances with the advent of the Pandemic, mainly in the education sector. With this, many educators who did not use TDIC, felt challenged, abruptly, to continue their teaching work, through remote classes. Feeling the need to take ownership of new teaching methodologies supported by technological tools. This work presents an experience report lived in the Supervised Internship in Computing with a public school of elementary education in the municipality of Itacoatiara, interior of the State of Amazonas. The experience of using TDIC to support teaching in remote education is reported. The results demonstrate the importance of continuing teacher education and explain the symbiosis in the relationship between University and School, in overcoming challenges and adversity in the teaching-learning process in times of pandemic of covid-19.
ÍNDICE DA QUALIDADE DA ÁGUA NO IGARAPÉ-AÇU (SÃO BRAZ) NO MUNICÍPIO DE SANTARÉM, PARÁ, AMAZÔNIA
Authors: Aquino Raissa Pinto de , Galvão Raiane Rodrigues , Lima Ana Carolina da Silva , Lobato Letícia Garcia , Repolho Alan Gabriel Ferreira , Moura Lucinewton Silva de
Published: December 2024

The Water Quality Index (WQI) is a methodology that has been used to evaluate the quality standard of water resources. Therefore, the objective of this study is to evaluate the AQI of a peri-urban stream (Igarapé-Açu) based on its physical-chemical and microbiological characteristics in a perimeter within the São Braz community within the municipal limit of Santarém-PA, the results were evaluated with based on Resolution of the National Environmental Council (CONAMA) No. 357/2005. Data collection was carried out at six sampling points, where some parameters were obtained in situ and others were carried out at the Laboratory of Chemistry applied to Toxicology, Environmental Sanitation and Water Resources, Universidade Federal do Oeste do Pará (UFOPA). The IQA results obtained for the six points were: P1=64.5; P2=57.3; P3=55.6; P4=51.7; P5=59 and P6=60.3, based on the classification of the São Paulo State Environmental Company (CETESB), the points were classified as Good, remaining green. It is also important to highlight the importance of carrying out these studies on water resources in the Amazon, as it has the highest percentagem of fresh water in the world, and this inspection should be a concern for governments.
O IMPACTO DA DOENÇA DO SILICONE NA ATUALIDADE
Authors: Sá Emanuelly de Barros Dias de , Panseri Tatiana Falcão Moraes , Sampaio Maria Gabriela Osório Grangeiro de Sá Barreto , Jovino Camila de Farias , Amorim Regianne Fabricia Arruda Silva , Barros Diego Rodrigues , Tricarico Eliane da Costa , Rocha Daniela Alves , Machado Marcia , Brito Gael Lyan Barbosa Verissimo de , Santos Francisco Jenian Dias dos
Published: December 2024

Silicone disease, also known as Asia Syndrome (Autoimmune Syndrome Induced by Adjuvants), is an emerging condition associated with the presence of silicone implants and other adjuvant substances in the body. This condition has generated increasing medical and scientific interest due to its impacts on patients’ physical and mental health. This review article explores the epidemiological, clinical and socioeconomic aspects of silicone disease, analyzing recent studies available in databases, including the Regional Portal of the Virtual Health Library (VHL).
ECOBATALHA: RELATO DE EXPERIÊNCIA COM GAMIFICAÇÃO PARA O ENSINO DA CADEIA ALIMENTAR NO ENSINO MÉDIO
Authors: Corrêa Marcos Pinto , Holanda Fabrício Holanda e , Lima José Wallerson Farias
Published: December 2024

O artigo aborda a aplicação do jogo EcoBatalha como uma ferramenta pedagógica inovadora voltada para o ensino da cadeia alimentar (Ecologia) em turmas do Ensino Médio na disciplina de Biologia. O objetivo da pesquisa é verificar o impacto do jogo na compreensão dos conceitos ecológicos pelos alunos, como níveis tróficos e interações entre espécies, utilizando a gamificação para promover o aprendizado de maneira lúdica e interativa. O método adotado inclui o desenvolvimento do jogo baseado na mecânica do UNO e sua implementação em sala de aula, seguida de testes e refinamentos com base no feedback dos alunos e professores. Os resultados indicam que o EcoBatalha, assim como outras metodologias gameficadas, aumenta o engajamento dos estudantes, melhora a retenção de conteúdo e facilita a compreensão dos conceitos. Pode-se então afirmar a eficácia do jogo como recurso educacional, sugerindo sua potencial utilização em outros contextos e níveis de ensino, além de destacar a importância de jogos didáticos na promoção de uma aprendizagem significativa.
The Analysis Study of Surgical Management of Hernia Inguinalis in Children : A Pediatric Surgery Systematic Review
Authors: Yosie Yulanda Putra  , Ririn Azhari
Published: December 2024

Background: Inguinal hernia is a type of abdominal wall hernia, accounting for 7% of surgical consultations and 12% of total surgical procedures globally. Inguinal hernia can occur at any age, and premature infants have the highest incidence. Surgical treatment for inguinal hernia in children is necessary to avoid severe complications. Methods: This systematic review followed the PRISMA 2020 guidelines, focusing on full-text articles published in English between 2014 and 2024. Editorial and review articles without DOI were removed to ensure only high-quality sources were used. A comprehensive literature search process was performed through leading databases such as ScienceDirect, PubMed, and SagePub to identify studies relevant to this research topic. Results: An initial database search revealed more than 1000 publications relevant to this topic. After a thorough three-stage screening process, eight studies were selected based on pre-defined inclusion criteria and deemed eligible for further in-depth analysis. Each selected study underwent a thorough critical appraisal to ensure its quality and relevance, thus providing a solid foundation for a comprehensive study on the role of surgical management in the management of pediatric inguinal hernia. Conclusion: Laparoscopy is a minimally invasive procedure that requires specialized equipment that may not be available at all centers. Laparoscopic repair is gaining popularity due to its advantages over open surgery. Laparoscopic surgery is a viable option, but it has not shown significant advantages in terms of recurrence or short-term outcomes when compared to open surgery.
The Analysis Study of Surgical Management of Intussusception : A Pediatric Surgery Systematic Review
Authors: Yosie Yulanda Putra  , Ririn Azhari
Published: December 2024

Background: Intussusception, a common abdominal emergency in children under three years of age, can lead to serious complications due to abnormal bowel movements, anatomical abnormalities, and infection. Surgical management is required if non-surgical reduction fails. Methods: This systematic review adheres to the PRISMA 2020 principles, focusing on full-text papers published in English between 2014 and 2024. Editorial and review articles without DOIs were removed to ensure that only high-quality sources were included. A comprehensive literature search was performed using major databases such as ScienceDirect, PubMed, and SagePub to uncover studies related to this research issue. Results: The database search identified over 1000 relevant publications, and eight were selected for in-depth analysis. Each study underwent rigorous critical appraisal to ensure quality and relevance, which formed the basis for a comprehensive review of the role of surgical management in the management of pediatric intussusception. Conclusions: Intussusception is a common condition in children under three years of age, with 85% of cases occurring during infancy. Surgical management is critical to the clinical outcome, with ultrasonography being the preferred diagnostic method. Secondary intussusception occurs in 1.5 to 15% of cases. In developing countries, surgical management is more common due to late diagnosis and limited access to radiological reduction methods.
TOWARDS THE ELIMINATION OF SOCIAL EXCLUSION
Authors: Roy Smritikana ,   Research Scholar, Department of Education, Sidho-Kanho-Birsha University, Purulia, West Bengal, India
Published: December 2024

Education is the fundamental key to eradicate all the evils from the society. One of the major issues that puts significant effect in the overall progress of society is social exclusion. Present paper is an attempt to make a clear view on social exclusion and probable way outs to make society free from social exclusion. Education plays a crucial role to make everyone equalize and also in the creation of an inclusive and sustainable society. The main focus of the study is to put light on education as a mean of unlocking socio-educational inclusion and also women education as the key of women empowerment which have significant role in reducing the chances of social exclusion.
Adopting Industry 4.0 in India’s Automotive Sector: Challenges, Enablers, and Policy Implications
Authors: Perody Shwetha H. , Sudhakara A. M.
Published: December 2024

This paper examines the adoption of Industry 4.0 technologies within the Indian automotive sector, summarizing the transition towards smart manufacturing and identifying key challenges and enablers. This study employed a qualitative literature review method, organizing the findings into meaningful segments using the ABCD framework to distil large volumes of data into core insights. The framework categorizes the advantages, benefits, constraints, and disadvantages associated with Industry 4.0. The research highlights several key barriers to adoption, including high implementation costs, a lack of a skilled workforce, and cybersecurity risks. Government initiatives, such as the Make in India campaign, play a crucial role in enabling transformation but require better alignment with industry needs. This study relies on secondary data sources, which limits its ability to capture real-time developments and sector-specific nuances. The absence of primary data collection restricts a deeper exploration of emerging trends. This research provides a structured evaluation of the impact of Industry 4.0 on the automotive industry in India. It captures the essence of digital transformation in manufacturing and offers actionable policy recommendations, reflecting the challenge of summarizing complex trends and transformations into concise takeaways for academic and practical use.
The Role and Impact of Social Entrepreneurship. Case Study: St. Dumitru – Mavrogheni Kindergarten
Authors: VĂDUVA Constantin-Daniel
Published: December 2024

Social entrepreneurship has emerged as a transformative approach to addressing societal challenges using innovative business practices. This article explores this concept, emphasizing its role in fostering positive social impact. The paper aims to provide a brief definition of the concept of social entrepreneurship and to highlight the case of St. Dumitru – Mavrogheni kindergarten. the author analyzes the key characteristics that differentiate social entrepreneurship from traditional entrepreneurship using a comprehensive review and qualitative analysis. The case study of a church kindergarten illustrates the practical application of social entrepreneurship. The analysis highlights how this social enterprise effectively mobilizes resources, engages stakeholders, and measures impact, despite challenges such as funding constraints and scalability issues. The findings highlight the role of social entrepreneurship in driving social and economic change, particularly in underserved areas, emphasizing the potential for significant social impact. Recommendations are offered to support the development of social entrepreneurship, ensuring they can tackle some of the society's most pressing problems.