bluuebunny/crossref_metadata_2025 huggingface dataset:
Lack of Association Between Recent Cannabis Use and Advanced Liver Fibrosis Among HIV-positive Heavy Drinkers
Authors: Fuster Daniel , So-Armah Kaku , Cheng Debbie M. , Coleman Sharon M. , Gnatienko Natalia , Lioznov Dmitry , Krupitsky Evgeny M. , Freiberg Matthew S. , Samet Jeffrey H.
Published: June 2021

Aims:

This study aimed to analyze the association between any past-month cannabis use
and advanced liver fibrosis.

Background:

Cannabinoid receptors play a role in acute and chronic liver injury, but human studies addressing the impact of cannabis use on liver fibrosis have shown mixed results.

Objectives:

The objective of this study was to explore and estimate the association between pastmonth
cannabis use and advanced liver fibrosis (ALF) in a cohort of Russian HIV-positive individuals
with heavy alcohol use and a high prevalence of hepatitis C virus (HCV) coinfection.

Methods:

Baseline data were analyzed from participants of the ZINC study, a trial that enrolled
HIV-positive Russian patients without prior antiretroviral therapy. Cannabis use during the prior
month was assessed at study entry. ALF was defined as FIB-4>3.25 and APRI>1.5. Transient elastography
was used to detect advanced liver fibrosis among participants with FIB-4 values in the intermediate
range (between 1.45 and 3.25).

Results:

Participants (n=248) were mostly male (72.6%), young (median age of 33.9 years), infected
with HCV (87.9%), and did not have advanced immunosuppression (median CD4 count 465).
Cannabis use was uncommon (12.4%), and the prevalence of advanced liver disease was 21.7%.
The prevalence of ALF was similar among those who used cannabis compared to those who did
not (25.8% vs. 21.7%). We were unable to detect an association between cannabis use and ALF (adjusted
odds ratio: 1.28, 95% confidence interval: 0.53-3.12, p=0.59) in logistic regression models
adjusting for age, sex, heavy drinking, BMI, and CD4 cell count.

Conclusion:

In this exploratory study among HIV-positive heavy drinking Russians, we did not detect
an association between recent cannabis use and ALF. Larger scale studies, including more participants
with cannabis use, are needed to examine this relationship further.
Evaluation of Novel Substituted Furopyridines as Inhibitors of Protein Kinases Related to Tau Pathology in Alzheimer´s Disease
Authors: Schade N. , Koch P. , Ansideri F. , Krystof V. , Holzer M. , Hilgeroth A.
Published: June 2021

Background:

Alzheimer´s disease (AD) is characterized by a progressive neuronal degeneration
caused by two pathological hallmarks, hyperphosphorylated tau protein aggregated into tau
filaments and amyloid precursor protein derived beta amyloid peptides aggregated into extracellular
amyloid plaques. All attempts so far to find effective drugs failed in clinical trials. AD is a multifactorial
disease, so that selective drugs to target one AD-relevant structure alone may not be sufficient.

Objective:

We built novel furopyridines with various substitution patterns to evaluate them as protein
kinases inhibitors of enzymes related to tau pathology.

Methods:

Furopyridine derivatives were synthesized and purified using column chromatography.
The protein kinase inhibitory properties were determined in ATP-competition assays with determined
affinity constants for the most active compounds.

Results:

The compounds were prepared in simple two-component reactions of substituted 1,4-
dihydropyridines and respective quinones to obtain various substitutions of the molecular furopyridine
scaffold. The substituent effects on the determined kinase inhibitory properties of cdk1,
cdk2, Fyn, JNK3 and gsk-3β are discussed.

Conclusion:

Various 3-substitutions were found most sensitive for the protein kinase inhibition depending
on the length, nature and a substituent positioning within. We identified compounds as inhibitors
of several kinases as a tool to potentially combat the disease progress in a multitargeting
approach.
A Two-step Electrodeposition of Pd-Cu/Cu2O Nanocomposite on FTO Substrate for Non-enzymatic Hydrogen Peroxide Sensor
Authors: Huan Ke , Tang Li , Deng Dongmei , Wang Huan , Si Xiaojing , Yan Xiaoxia , Luo Liqiang
Published: June 2021

Background:

Hydrogen peroxide (H2O2) is a common reagent in the production and living,
but excessive H2O2 may enhance the danger to the human body. Consequently, it is very important
to develop economical, fast and accurate techniques for detecting H2O2.

Methods:

A simple two-step electrodeposition process was applied to synthesize Pd-Cu/Cu2O
nanocomposite for non-enzymatic H2O2 sensor. Cu/Cu2O nanomaterial was firstly electrodeposited
on FTO by potential oscillation technique, and then Pd nanoparticles were electrodeposited on
Cu/Cu2O nanomaterial by cyclic voltammetry. The chemical structure, component, and morphology
of the synthesized Pd-Cu/Cu2O nanocomposite were characterized by X-ray diffraction, scanning
electron microscopy and X-ray photoelectron spectroscopy. The electrochemical properties of
Pd-Cu/Cu2O nanocomposite were studied by cyclic voltammetry and amperometry.

Results:

Under optimal conditions, the as-fabricated sensor displayed a broad linear range (5-4000
μM) and low detection limit (1.8 μM) for the determination of H2O2. The proposed sensor showed
good selectivity and reproducibility. Meanwhile, the proposed sensor has been successfully applied
to detect H2O2 in milk.

Conclusion:

The Pd-Cu/Cu2O/FTO biosensor exhibits excellent electrochemical activity for H2O2
reduction, which has great potential application in the field of food safety.
A Highly Efficient Photocatalyst Based on Layered g-C3N4/SnS2 Composites
Authors: Wang Yina , Wang Le , Wang Jiwei , Du Jimin
Published: June 2021

Background:

In this report, the layered g-C3N4/SnS2 composite was successfully fabricated
by a facile hydrothermal route.

Methods:

The ultraviolet-visible spectroscopy data presented that such layered g-C3N4/SnS2 catalysts
showed a remarkable visible-light absorption, hence significantly enhancing the catalytic activity.
Particularly, the g-C3N4/SnS2 catalysts showed an outstanding catalytic performance for the degradation
of methylene blue (~ 98.1%) under visible light irradiation that is much better than that of pure
SnS2 (~ 86.7%) and pure g-C3N4 (~ 67.3%).

Results:

The remarkable photocatalytic performance is ascribed to its layer structure resulting in a
large surface area, which not only improves the ion transfer rate but also provides abundant surface
reaction sites.

Conclusion:

Our work demonstrates that the layered g-C3N4/SnS2 can be considered as an exceptional
candidate for a highly-efficient photocatalyst.
Liquisolid Orodispersible Tablets of Valeriana officinalis L. Root Extraction: Formulation, Development and Evaluation
Authors: Asgarirad Hossein , Farmoudeh Ali , AmirKhanloo Shervin , Babaei Amirhossein , Hosseini Seyyedeh Saba , Kishani Yashar
Published: June 2021

Background:

Valerian root extract is used in traditional medicine to treat sleep disorders.
According to previous studies, sedative effects are related to the presence of valerenic acid. Formulating
orodispersible tablets (ODTs) is an effective and cost-benefit technique for accelerating drugs'
therapeutic effects. This study aimed to formulate ODTs of valerian root extract and evaluate their
properties.

Materials and Methods:

Valerian root was extracted by percolation in 70% ethanol. The solubility of
valerenic acid was investigated in various liquid carriers. The extract was uniformly dispersed in the
selected carrier (Tween 80), then mixed with other excipients, and compressed into tablets. Fourteen
formulations with different amounts of sodium starch glycolate (SSG, as a super disintegrant) and
camphor (as a sublimating agent) were prepared. The physicochemical properties of the ODTs, drug
release rates, and microbial limit tests (MLTs) were studied.

Results:

Both SSG and camphor accelerated tablet disintegration rates and their composition showed a
synergistic effect (P<0.05). The infrared spectroscopy revealed no chemical interaction between formulation
components. The MLTs confirmed that a limited number of microbial colonies were grown
in the liquid medium, and no pathogen growth occurred in the specific culture media.

Conclusion:

The results revealed that Valerian ODT's physicochemical properties were significantly
improved compared to conventional tablets. The technique can be utilized for other poorly watersoluble
pharmaceuticals.
A Path-based Method for Identification of Protein Phenotypic Annotations
Authors: Gao Jian , Hu Bin , Chen Lei
Published: June 2021

Background:

Identification of protein phenotypic annotations is an essential and challenging
problem in modern genetics. Such problem is related to some serious diseases, including
cancers, HIV and so on. The factors of genotype and environment increase the difficulties in determining
the phenotype of proteins. The experiment methods to achieve such a goal are always timeconsuming
and expensive.

Objective:

The aim of this study was to design a quick and cheap method for determining the phenotypes
of proteins.

Methods:

In this study, we proposed a network computational method to identify novel phenotypic
annotations of proteins. To execute such method, a heterogeneous network was constructed, which
contained three sub-networks: protein network, phenotypic type network, and protein-phenotypic
type network. The method tried to find out all paths with limited length, which connected one protein
and one phenotypic type. A scoring scheme was adopted to count obtained paths and induced a
score to indicate the associations between them.

Results and Conclusion:

The ROC and PR curve analyses were done to evaluate the performance
of the method, indicating the utility of the method. Our method was superior to other network
methods, which incorporated popular network algorithms.
Identification of Risk Molecular Subtype of Colon Cancer with Lymphovascular Invasion
Authors: Jin Qing , Liang Binhua , Chen Xiujie , Liu Huiwen
Published: June 2021

Background:

Although surgical resection generally yields excellent outcomes, a number
of patients with colon cancer still have relapse or metastasis after surgery. Adjuvant chemotherapy
in tumor stage III has been demonstrated to eradicate micrometastasis and improve survival, whereas
the benefits of adjuvant chemotherapy in tumor stage II remain controversial. The leading cause
is the lack of understanding of the molecular basis of underlying metastatic mechanisms.

Objective:

This study aimed to identify molecular subtype(s) of colon cancer with a high risk of
metastasis and provide potential biomarkers for prognostic prediction in tumor stage II.

Method:

Based on the assumption that colon cancer evolves because of the stepwise accumulation
of a series of genetic mutations, we performed a systematic investigation on the molecular basis of
colon cancer through applying restart random walk on the PPI network. To compare functional similarity
of patients, we extracted mutation-propagating modules of each patient and calculated their
enrichment score in 50 hallmark gene sets. According to functional similarity matrix, we classified
colon cancers with positive lymphovascular invasion and the prognosis of molecular subtypes. We
determined the molecular characteristics of subtypes by enrichment analysis of subtype-specific
genetic mutations. Additionally, we identified potential biomarkers for predicting patients with a
high risk of metastasis in stage II through differential analysis of miRNA expression profiles of
subtypes. Then we used two independent data sets to construct a random forest classifier and performed
10-fold cross-validation of miRNA biomarkers.

Results:

Firstly, we identified two molecular subtypes of colon cancer with positive lymphovascular
invasion as well as their associated biological characteristics: LVI1=Canonical subtype (110,
85%); LVI2=Metastatic subtype (20, 15%). Secondly, we identified 11 miRNA biomarkers for predicting
patients with a high risk of metastasis in tumor stage II.

Conclusion:

Our findings put forward a detailed classification for colon cancer and provided risk
biomarkers for stage II patients to determine whether to take adjuvant chemotherapy after surgery.
System Identification of Dampers Using Chaotic Accelerated Particle
Swarm Optimization
Authors: Talatahari S. , Talatahari B. , Tolouei M.
Published: June 2021

Aims:

Different chaotic APSO-based algorithms are developed to deal with high non-linear
optimization problems. Then, considering the difficulty of the problem, an adaptation of these algorithms
is presented to enhance the algorithm.

Background: :

Particle swarm optimization (PSO) is a population-based stochastic optimization technique
suitable for global optimization with no need for direct evaluation of gradients. The method
mimics the social behavior of flocks of birds and swarms of insects and satisfies the five axioms of
swarm intelligence, namely proximity, quality, diverse response, stability, and adaptability. There are
some advantages to using the PSO consisting of easy implementation and a smaller number of parameters
to be adjusted; however, it is known that the original PSO had difficulties in controlling the balance
between exploration and exploitation. In order to improve this character of the PSO, recently, an
improved PSO algorithm, called the accelerated PSO (APSO), was proposed, and preliminary studies
show that the APSO can perform superiorly.

Objective:

This paper presents several chaos-enhanced accelerated particle swarm optimization methods
for high non-linear optimization problems.

Method:

Some modifications to the APSO-based algorithms are performed to enhance their performance.
Then, the algorithms are employed to find the optimal parameters of the various types of hysteretic
Bouc-Wen models. The problems are solved by the standard PSO, APSO, different CAPSO,
and adaptive CAPSO, and the results provide the most useful method. The sub-optimization mechanism
is added to these methods to enhance the performance of the algorithm.

Result:

Seven different chaotic maps have been investigated to tune the main parameter of the APSO.
The main advantage of the CAPSO is that there is a fewer number of parameters compared with other
PSO variants. In CAPSO, there is only one parameter to be tuned using chaos theory.

Conclusion:

To adapt the new algorithm for susceptible parameter identification algorithm, two series
of Bouc-Wen model parameters containing standard and modified Bouc-Wen models are used. Performances
are assessed on the basis of the best fitness values and the statistical results of the new approaches
from 20 runs with different seeds. Simulation results show that the CAPSO method with
Gauss/mouse, Liebovitch, Tent, and Sinusoidal maps performs satisfactorily.
Effect of Infill Pattern, Infill Density, and Infill Angle on the Printing Time and Filament Length of 3D Printing
Authors: Suteja Jaya
Published: June 2021

To optimize the 3D printing process, the influence of its parameters on the performance of the printing process needs to be investigated. This research investigates the effect of infill pattern, infill density, and infill angle on the printing time and the filament material length. First, this research collected the printing time and the filament length data for each combination of infill pattern, infill density, and infill angle. The data collection was conducted by implementing Repetier-Host v.2.1.6 software as a data acquisition tool. Then, the General Linear Model was applied to analyze the effect of infill pattern, infill density, and infill angle on the printing time and filament length. Based on the analysis, higher infill density increases the printing time for each infill pattern and each infill angle. Also, higher infill density increases the filament length for each infill pattern and each infill angle. The implementation of the Gyroid type of infill pattern reduces the required printing time for each density. Meanwhile, the implementation of the 3D honeycomb type of infill pattern increases the filament length for each infill angle. The use of the 45° infill angle increases the filament length and printing time. To reduce the filament length and printing time, the 90° infill angle should be implemented.
Pengaruh Thermal Shock dan Komposisi Evaporation Boats, Semen Tahan Api, dan Pasir Silika terhadap Kekuatan Impact dan Foto Makro Lining Refractory
Authors: Fajri Novila Rojabni , Rusiyanto Rusiyanto , Widodo Rahmat Doni , Sumbodo Wirawan , Fitriyana Deni Fajar
Published: June 2021

The thermal shock behavior of ceramic refractory materials is of particular interest. Refractory materials are submitted to local temperature gradients in service that originate thermal stresses and thermal shock damage to the material. However, thermal shock treatment on the refractory made from evaporation boat waste is not well documented. The purpose of this study is to determine the effect of thermal shock on the strength of refractory with various compositions. In this study, the refractory was made using 100% refractory cement (sample 1). For Sample 2, the refractory was made from a mixture of refactory cement and evaporation boats waste, each of 50%: 50%. Meanwhile, specimen 3 of the refractory is made from a mixture of refactory cement, evaporation boat waste, and silica sand of 40%: 50%: 10%, respectively. The Thermal shock treatment is carried out at a temperature range of 100 – 700oC for each specimen. The effect of thermal shock treatment on the mechanical properties of each refractory specimen was investigated using the impact and macrography test. Temperature variations in thermal shock have different effects on the level of impact strength on impact test specimens. The lowest strength was 0,012297735 J/mm2 at thermal shock 7000C in sample 3, and the highest impact strength was 0,03928934 J/mm2 at 400oC thermal shock temperature in sample 2. The macrographic examination shows the higher the thermal shock temperature, the greater the fracture produced when the impact test is carried out. This is because the hardness of the refractory material increases.
Karakterisasi Serbuk Timah dari Sistem Atomisasi Gas Argon Panas - Sub Sistem Gas Alir Tabung Gas
Authors: Basyir Abdul , Aryanto Didik , Jayadi Jayadi , Widayatno Wahyu Bambang , Wismogroho Agus Sukarto
Published: June 2021

The tin powder was used in some applications and technology such as for part manufacture through alloying, pressing, and sintering process, mixing material for the pyrotechnic application, the main material for solder pasta, mixing material on tin chemical, and others. Therefore, the demand for tin powder with a small size, spherical shape, and high purity is increasing severely. Indonesia (PT. Timah Tbk.) is one of the world’s largest producers of tin raw materials. This raw material can be processed be as powder by the atomization method. In this research, hot argon gas atomization system was used to generated tin powder. Raw tin was melted in a melting chamber with temperature variations of 600, 700, 800, and 900 °C. This experiment generates powder with a dominant size of 37 – 150 mm. Meanwhile, for size powder of 0 – 30 mm, dominated by size range of 0 – 10 mm. Furthermore, the size powder of 0 – 30 mm is composed of tin phase, without tin oxide. The tin powder of melting chamber temperature of 900 °C produces the largest tin powder with a size of 0 – 10 mm and spherical powder.
Kekuatan Mekanis Antibacterial Resin Campuran Titanium Dioksida
Authors: Budiprasojo Azamataufiq , Erawantini Feby
Published: June 2021

The aim of this research is to analyze the effect of Titanium Dioxide (TiO2) nanoparticles as resin concentrate on mechanical strength. The tested mechanical strength is Bending strength, Impact Strength, and Microhardenest Strength. The types of resin used in this study were acrylic resin without conventional modification and acrylic resin with an additional 0.01 gr and 0.06 gr of TiO2. Specimen dimensions are made revered to ISO 20795-1 (2008) standard specifications. Mechanical strength was determined by using the universal testing machine, Izod pendulum impact testing machine, and also Vickers microhardness tester. From the analysis, the researcher found that the bending strength of resin acrylic was greatly decreased by increasing the TiO2 concentration. It happens in both TiO2 0.01gr and 0.06gr of acrylic resin compared to the non TiO2 resin. The impact strength of 0.01gr TiO2 acrylic resin was significantly increased compared to non TiO2 acrylic resin. But on the other hand for 0.06gr acrylic resin, impact strength was decreased and recorded the lowest impact strength. The highest Micro hardness strength was found in 0.06gr TiO2, It is significantly increased compared to 0.01gr TiO2 and 0gr TiO2. The general conclusion is, adding 0.01gr TiO2 nanoparticles as concentrated into acrylic resin can significantly increase the bending strength, bending strength, and microhardness strength. Meanwhile, adding 0.06gr Tio2 nanoparticles as concentrated into acrylic resin can only increase the bending strength and the microhardness strength, but not for its impact strength.
Criteria for the selection of railway stations for the placement of freight terminals for handling “Cold Express” container trains
Authors: Romenskiy D. Yu. , Shvedin K. I. , Nasybullin A. M. , Romenskaya M. V.
Published: June 2021

An approach to the selection of locations for compact container sites at railway stations of main railway lines for carrying out freight operations with transit container trains is described on the example of an investment project of the JSC “Russian Railways” for organizing transportation by “Cold Express” trains. To ensure the possibility of organizing the motion of container freight trains with its reception at the station directly to the loading and unloading front, certain conditions listed in the article must be met. The approach is based on the principle of minimizing costs and maintaining the operational parameters of the reconstructed railway stations while implementing the principles of container logistics. It was concluded that the reference railway station for placing on it a container terminal specializing in handling container transport trains (including “Cold Express” trains) should be a station that has a little-used electrified receiving-departure track with a length of at least 1050 m, for which there is the possibility of receiving and departure trains in all directions and near which there is an open freight area with a hard surface with the possibility of approaching trucks. Also, conditions for the unimpeded operation of loading equipment should be ensured, i. e. there should be no obstacles in the form of pedestrian bridges and overhead catenary supports. On the pilot route Vladivostok—Moscow—St. Petersburg, 18 stations were selected, located in large cities or tend towards large cities. The analysis showed that in real conditions there are no stations that fully meet these criteria, from which it was concluded that it was necessary to carry out capital-intensive measures of various volumes associated with the achievement of the necessary parameters of the stations, such as electrification or lengthening of the track, reconstruction of the station necks, arrangement of the site, car entrances, as well as other measures.
Ogilvie Syndrome Following Caesarean Section: A Case Report
Authors: Sninate Sanae , Bellamlih Habib , Allioui Soukaina , Jroundi Leila , Laamrani Fatima Zahrae
Published: June 2021

Background. Ogilvie syndrome is a rare postpartum complication. It is characterized by an acute colonic pseudo-obstruction which occurs in the absence of a mechanical cause. Early detection of the diagnosis is essential to avoid cecal perforation.

Case report. We report a case of Ogilvie syndrome following caesarean section in a 39-year-old woman (gravida 2, para 2) with a history of secondary infertility 10 years ago due to tubal stenosis and subserous fibroma, which led to the indication for cesarean section in second pregnancy at 39 weeks of gestation. Three days after cesarean section, the patient presented with significant abdominal distension and tenderness, vomiting, weakness, and nausea; an abdominal X-ray showed cecal distension. Abdominal computed tomography scan with intravenous contrast revealed distension of the ascending and transverse colon with air-fluid levels but without transitional mechanical obstruction. The patient was successfully treated.

Conclusions. Ogilvie syndrome is a rare but serious complication that should be considered in fit young patients who present with pain, severe abdominal distension and failure to pass flatus after caesarean section.
The Relationship Between Perceived Parental Attitude and Life Satisfaction Among University Students
Authors: Işik Nurten Arslan
Published: June 2021

Introduction. The effect of parental attitudes and behaviors in raising their children on the individual’s life has been the subject of numerous studies for many years. There is a strong correlation between parental attitudes and the child’s ability to be satisfied with life.

The objective of the research was to determine the relationships between perceived parental attitudes (overprotection, rejection, emotional warmth) and life satisfaction among university students. We investigated whether parental attitudes play a role in predicting life satisfaction among university students, and what role they play.

Materials and Methods. The study was conducted from June 2020 to September 2020. Data were collected using Google Forms. Each person consented to anonymously participate in the study and was informed about the objectives of the study being a descriptive one. The population of the study consisted of nursing students enrolled in the Faculty of Health Sciences. For this purpose, 220 students at the age of 20 to 30 years participated in the study. The assessment battery consisted of Student Demographic Form, the Short-Egna Minnen Beträffande Uppfostran (Own Memories of Upbringing), and the Life Satisfaction Scale.

Results. There was a significant negative correlation between maternal rejection and life satisfaction among the students. Male students were more likely to perceive their fathers as being disapproving than female students did. These findings were discussed in line with the studies in the related literature.

Conclusions. High life satisfaction is a variable that protects young people from risk factors. Therefore, a focus should be placed on increasing life satisfaction among students. Parental attitude is an effective factor for life satisfaction among students. For this reason, it can be said that it would be beneficial to inform families about appropriate parental attitudes to increase their children’s life satisfaction.
Technology as a Tool for Transnational Organized Crime
Authors: Tung Gurpreet
Published: June 2021

Using technology to commit crimes is becoming much more prevalent. The internet has provided organized criminal entities anonymity and accessibility to criminal networks across the world to expand their illicit businesses. Technology is allowing for different organizations to co-exist and assist one another to achieve their goals. Organized crime entities are not only utilizing cyberspaces to communicate with networks across the globe but are also utilizing these spaces to aid in money laundering. Money laundering processes have begun to move online to better obscure assets in relation to criminal activity. Therefore, technology is creating a more dynamic and complex world to combat organized crime.
Utjecaj poremećaja iz spektra autizma na obitelj
Authors: Kosić Radoslav , Duraković Tatić Alida , Petrić Daniela , Kosec Tanja
Published: June 2021

Poremećaj iz spektra autizma (engl. autism spectrum disorder, ASD) neurorazvojni je poremećaj kojeg obilježavaju kvalitativne anomalije u društvenoj interakciji i u modalitetima komunikacije koje su popraćene ograničenim, ponavljajućim i stereotipnim repertoarom interesa i aktivnosti te nejednolikim intelektualnim razvojem. Uzrok autizma se ne zna. Smatra se kako je riječ o multifaktorijalnom poremećaju, a povezuje se s genetskim i okolišnim čimbenicima. Svrha rada jest dati pregled znanstvene i stručne literature na temu utjecaja djeteta s autizmom na obitelj. Roditelji se moraju suočiti s postavljenom i teško prihvaćenom dijagnozom te je moraju prenijeti ostalim članovima obitelji. Potrebna je prilagodba novom načinu života. Proces prilagodbe, prihvaćanja i privikavanja je dugotrajan, a kod nekih roditelja traje cijeli život. Obitelj poprima novu ulogu, čiji je glavni cilj podizanje djeteta i preuzimanje pune odgovornosti za dijete koje ovisi o angažmanu vlastite obitelji. Uočena je viša stopa razvoda kod roditelja, negativni utjecaji kroničnog stresa i izoliranje iz zajednice. Negativan se utjecaj uočava i kod braće i sestara djece s autizmom. Od izrazite je važnosti edukacija roditelja. Često se roditelji u procesu prihvaćanja počinju educirati i sudjelovati aktivno u grupama podrške i prosvjećivanju zajednice te zagovaranju za svoje dijete.
Procjena zdravstvenog stanja stanovnika Primorsko-goranske županije
Authors: Janković Suzana , Beg Zrakić Ljiljana , Malatestinić Đulija , Pugel Sanjin
Published: June 2021

Procjenom zdravstvenog stanja stanovnika data je slika zdravlja Primorsko-goranske županije, na temelju koje se mogu identificirati i ocijeniti zdravstvene potrebe stanovništva. Prilikom procjene zdravlja i zdravstvenih potreba stanovnika Županije korištena je rutinska zdravstvena i demografska statistika i analizirani su demografski i zdravstveni pokazatelji. U istraživanju zdravstvenih pokazatelja korišteni su podatci Svjetske zdravstvene organizacije u strategiji unaprjeđenja zdravlja „Zdravlje za sve u 21. stoljeću” i podatci mortalitetne statistike Hrvatskog zavoda za javno zdravstvo, a analiza pokazatelja provodila se deskriptivnom statističkom metodom, prvenstveno komparativnom analizom. Razina prikaza i interpretacije podataka jest Županija, odnosno njezine četiri podregionalne cjeline.
Doprinos je ovoga rada podrška donositeljima odluka u promicanju, održavanju i unaprjeđenju zdravlja u zajednici, odnosno kvalitete življenja stanovništva na području Županije u cijelosti. Ocjena može poslužiti za odabir novih prioriteta, kao i podloga za izradu smjernica budućih intervencija u zajednici.
Abrupcija na polazištu zajedničke karotidne arterije bez neurološkog deficita
Authors: Figl Josip , Šnajdar Irena , Papeš Dino , Lončarić Yvonne , Belina Dražen , Halužan Damir
Published: June 2021

Objective: In this case, we present a patient who despite iatrogenic common carotid artery disruption had no neurological impairment after vascular reconstruction. Case report: During the neck dissection in a young patient a complete abruption of the common carotid artery occurred. Median sternotomy was done for proximal bleeding control. Vascular reconstruction was done using temporary carotid shunting. The patient had no neurological consequences afterward. Conclusion: The lesion of major neck vessels is one of the most severe complications during the surgery which must be dealt with as soon as possible in best way in order to avoid permanent brain damage. In situations of iatrogenic lesions of major neck arteries heparin admission, which is usually normal therapy during vascular reconstruction, is not an option due to abrupt and uncontrollable bleeding. Thus, establishing surgically proximal and distal vascular control over the bleeding artery by vessel clamping and urgent placing of temporary intraluminal carotid shunting and best medical intraoperative therapy in this critical period of surgery might be the crucial therapeutic moment for brain protection.
Электродинамический плазменный двигатель с капиллярно-пористыми электродами
Authors: Мартыненко Ю.В. , Нагель М.Ю.
Published: June 2021

Предложена схема двигателя для космических аппаратов на основе стационарного электродинамического плазменного ускорителя с капиллярно-пористыми электродами. Такие электроды возобновляемы и не деградируют, а срок их службы ограничен запасом металла-наполнителя. Найдены режимы, при которых капиллярно-пористые электроды эффективны. При этих режимах рассмотренный ускоритель может дать тягу более десяти ньютонов и удельный импульс десятки km/s. В качестве металла-наполнителя капиллярно-пористых электродов могут быть использованы Li, S и Ga с пористыми матами из молибдена или вольфрама. Ключевые слова: плазменный двигатель, тяга, удельный импульс, капиллярно-пористые электроды.
Влияние электромагнитного поля промышленной частоты на физико-химические свойства микро- и нанопорошков алюминия
Authors: Мостовщиков А.В. , Тихонов Д.В. , Приходько Ю.С.
Published: June 2021

The paper investigates the effect of an electromagnetic field of industrial frequency 50 Hz on the change in the physicochemical properties of aluminum powders of different dispersion. It was found that due to the action of the field, their sorption capacity increases, which leads to a significant change in the properties of aluminum powders.
Использование спекловых изображений для определения локальных пластических деформаций, возникающих при многоцикловой усталости стали 09Г2С
Authors: Владимиров А.П. , Друкаренко Н.А. , Мызнов К.Е.
Published: June 2021

Using time-averaged speckle images on a sample of 09G2S steel made with two recesses with a radius of 2.5 mm, the plastic deformations occurring in the fatigue crack origin zone are estimated. It is shown that fatigue fracture occurs due to the localization of irreversible processes in a region less than 1 mm in size, the limit value of tensile plastic deformations is of the order of 10-1. As a precursor of destruction it is proposed to use the reduction of the normalized time autocorrelation function of the radiation intensity to negative values.
Papilomavirus bovino tipo 2 en un sarcoide equino en Costa Rica
Authors: Alfaro-Mora Ramsés , Castro Ruth , Rodríguez-Barahona Julia , Dolz Gaby
Published: June 2021

Objetivo: Identificar mediante técnicas moleculares la presencia de papilomavirus bovino (BPV) en un sarcoide equino, y realizar la caracterización histológica de este. Materiales y métodos: A partir de lesiones de sarcoide en una yegua de raza pinto americano se realizó la extracción de ácidos nucleicos para su identificación mediante técnicas moleculares. Se amplificó el gen correspondiente al segmento L1 para papilomavirus a través de reacción en cadena de la polimerasa, se secuenció y luego fue analizado utilizando el algoritmo BLAST. Se realizó tinción de hematoxilina-eosina del tejido y se analizó en microscopio de luz 100X. Resultados: Se detectó BPV-2 en la lesión de sarcoide equino; el sarcoide se clasificó como nodular de acuerdo con sus características morfológicas e histológicas. La histopatología mostró una lesión fibrótica, con neoplasia exofítica y expansión del estrato espinoso. Conclusiones: El estudio demostró por primera vez la presencia de BPV-2 en un sarcoide equino en Costa Rica utilizando técnicas moleculares y su asociación con un sarcoide de tipo nodular.
Peer-to-Peer Social Media Communication About Dietary Supplements Used for Weight Loss and Sports Performance Among Military Personnel: Pilot Content Analysis of 11 Years of Posts on Reddit
Authors: Sharp Kendall J , Vitagliano Julia A , Weitzman Elissa R , Fitzgerald Susan , Dahlberg Suzanne E , Austin S Bryn
Published: June 2021

Background

Over 60% of military personnel in the United States currently use dietary supplements. Two types of dietary supplements, weight loss and sports performance (WLSP) supplements, are commonly used by military personnel despite the associated serious adverse effects such as dehydration and stroke.

Objective

To understand peer-to-peer communication about WLSP supplements among military personnel, we conducted a pilot study using the social media website, Reddit.

Methods

A total of 64 relevant posts and 243 comments from 2009 to 2019 were collected from 6 military subreddits. The posts were coded for year of posting, subreddit, and content consistent with the following themes: resources about supplement safety and regulation, discernability of supplement use through drug testing, serious adverse effects, brand names or identifiers, and reasons for supplement use.

Results

A primary concern posted by personnel who used supplements was uncertainty about the supplements that were not detectable on a drug test. Supplements to improve workout performance were the most frequently used.

Conclusions

Our pilot study suggests that military personnel may seek out peer advice about WLSP supplements on Reddit and spread misinformation about the safety and effectiveness of these products through this platform. Future directions for the monitoring of WLSP supplement use in military personnel are discussed.
Using Living Labs to Explore Needs and Solutions for Older Adults With Dementia: Scoping Review
Authors: Verloo Henk , Lorette Adrien , Rosselet Amoussou Joëlle , Gillès de Pélichy Estelle , Matos Queirós Alcina , von Gunten Armin , Perruchoud Elodie
Published: June 2021

Background

Numerous living labs have established a new approach for studying the health, independent living, and well-being of older adults with dementia. Living labs interact with a broad set of stakeholders, including students, academic institutions, private companies, health care organizations, and patient representative bodies and even with other living labs. Hence, it is crucial to identify the types of cocreations that should be attempted and how they can be facilitated through living labs.

Objective

This study aims to scope publications that examine all types of living lab activities, exploring the needs and expectations of older adults with dementia and seeking solutions, whether they live in the community or long-term health care facilities (LTHFs).

Methods

This scoping review was reported according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) recommendations for the extension of scoping reviews. We searched six bibliographic databases for publications up to March 2020, and a forward-backward citation chasing was performed. Additional searches were conducted using Google Scholar. The quality of the selected papers was assessed.

Results

Of the 5609 articles identified, we read 58 (1.03%) articles and retained 12 (0.21%) articles for inclusion and final analysis. All 12 articles presented an innovative product, developed in 4 main living labs, to assist older adults with cognitive disorders or dementia living in the community or LTHFs. The objectives of these studies were to optimize health, quality of life, independent living, home care, and safety of older adults with cognitive disorders or dementia, as well as to support professional and family caregivers or reduce their burdens. The overall methodological quality of the studies ranged from poor to moderate.

Conclusions

This scoping review identified several living labs playing a pivotal role in research aimed at older adults with dementia living in the community or LTHFs. However, it also revealed that living labs should conduct more better-quality interventional research to prove the effectiveness of their technological products or service solutions.

International Registered Report Identifier (IRRID)

RR2-10.2147/SHTT.S233130
A Randomized Controlled Trial Investigating the Feasibility of a Low-Intensity Psychological Intervention for Fear of Memory Loss and Quality of Life in Older Adults: Protocol for the Reducing Fear and Avoidance of Memory Loss (REFRAME) Study
Authors: O'Loughlin Patricia , Pavithra Pavithra , Regan John , Bennett Marc , Knight Rachel , Lenaert Bert , Marquez Melissa , Taddeo Michelle , Griffith James , Shapiro Rita , Farina Francesca
Published: June 2021

Background

Dementia is the most feared disease associated with aging. Prolonged fears about memory loss and dementia can have harmful consequences even in the absence of cognitive decline. Fear of dementia is associated with poorer health outcomes and psychological well-being and increased memory failures in older adults.

Objective

We will conduct a randomized controlled trial to determine the feasibility of a tailored, web-based mindfulness program to reduce fear of memory loss and increase quality of life in older adults experiencing heightened fear.

Methods

Eighty participants will be recruited and divided into 2 groups (40 in each group). One group will receive psychoeducation plus mindfulness training. A second group will receive psychoeducation, mindfulness training, and additional modules targeting maladaptive behavioral avoidance (ie, social and cognitive withdrawal).

Results

Our recent etiological model posits that maladaptive behavioral avoidance strategies critically underlie psychosocial dysfunction associated with fear of memory loss. Thus, we predict better outcomes in the second group, including reduced fear of memory loss (primary outcome), Alzheimer disease, anxiety, and subjective memory failures, and increased quality of life (secondary outcomes). Outcome measures will be applied at 5 time points (before, baseline, interim, and after the intervention, and at 3-month follow-up). Data will be analyzed using mixed models and correlations.

Conclusions

Results from this study will contribute to the current literature on dementia-related fear and improve our understanding of how to effectively address and reduce these fears.

Trial Registration

ClinicalTrials.gov NCT04821960; https://clinicaltrials.gov/ct2/show/NCT04821960.

International Registered Report Identifier (IRRID)

PRR1-10.2196/30514
Kalimat Imperatif dalam Film Yeoljeong-gateun Sori-hago Iss-ne
Authors: Perdana Ratih Ratna , Usmi Usmi
Published: June 2021

When communicating, humans as speakers of language will arrange words into meaningful sentences so listeners can understand the purpose of the speech. The speaker will determine the type of sentences and variety of language to use. In the event of spoken communication, there are various types of speech, one of which is imperative sentence speech. This research aims to analyze speech acts that uses imperative sentences in a film entitled Yeoljeong-gateun Soriha-go Iss-ne (열정같은 소리하고 있네). This research applies descriptive method with quantitative and qualitative approaches. Data were collected by applying note-taking techniques. The data were further identified and classified based on the imperative sentence theory by Lee (2016). The result of this study showed that 175 imperative sentences were found in the film corpus. These can be classified into 8 types of speech acts, namely speech acts of commands (43,4%), demands (28,6%), permission (6,9%), suggestion (5,7%), prohibition (5,1%), warning (5,1%), greeting (2,9%), and requests (2,3%). Meanwhile, the most used variety of languages in the film corpus is informal language or haeche with 132 sentences.
REQUEST STRATEGIES AS SEEN IN THE MOVIE SILVER LININGS PLAYBOOK
Authors: Tambulana Falminda Rahmadiyanti , Sutrisno Adi
Published: June 2021

This research aimed to investigate the types of request strategies used by the characters in the movie Silver Linings Playbook (2012). It also identified the types of request goals made by the characters. The data were taken from dialogues in the movie, which contained request utterances. The data were then classified into nine strategy types of request according to Blum-Kulka and Olshtain (1984), followed by the classification of the data into four types of request goals according to the theory proposed by Blum-Kulka et al. (1985, as cited in Forgas, 1985, p. 118). The result showed that 202 request strategies were made by the characters. The most frequently used request strategy found in the movie was a direct request, which was mood derivable with 111 occurrences (54.9%). Meanwhile, for request goals, requests for action was the most frequently implored type by the characters, and it was dominated by mood derivable strategy with 103 occurrences (64.8%).
Prediction of Surface Roughness after Turning of Duplex Stainless Steel (DSS)
Authors: Abdulateef Osamah F.
Published: June 2021

Feed Forward Back Propagation artificial neural network (ANN) model utilizing the MATLAB Neural Network Toolbox is designed for the prediction of surface roughness of Duplex Stainless Steel during orthogonal turning with uncoated carbide insert tool. Turning experiments were performed at various process conditions (feed rate, cutting speed, and cutting depth). Utilizing the Taguchi experimental design method, an optimum ANN architecture with the Levenberg-Marquardt training algorithm was obtained. Parametric research was performed with the optimized ANN architecture to report the impact of every turning parameter on the roughness of the surface. The results suggested that machining at a cutting speed of 355 rpm with a feed rate of 0.07 mm/rev and a depth of cut 0.4 mm was found to achieve lower surface roughness with,  an increase in the cutting speed and feed rate with the increases of the surface roughness. In addition, an increase in the depth of cut was found to reduces the surface roughness. The outcome of this study showed that ANN is a versatile tool for prediction of surface roughness and may be easily extended with greater confidence to various metal cutting processes.
The Application of Virtual Reality to (Mechatronics Engineering) by Creating an Articulated Robotic Work Cell Using EON Reality V9.22.24.24477
Authors: Allaq Aiman Al- , Jaksic Nebojsa , Al-Amili Hussein Ali , Mahmood Dhuha Mohammed
Published: June 2021

Virtual reality, VR, offers many benefits to technical education, including the delivery of information through multiple active channels, the addressing of different learning styles, and experiential-based learning. This paper presents work performed by the authors to apply VR to engineering education, in three broad project areas: virtual robotic learning, virtual mechatronics laboratory, and a virtual manufacturing platform. The first area provides guided exploration of domains otherwise inaccessible, such as the robotic cell components, robotic kinematics and work envelope.  The second promotes mechatronics learning and guidance for new mechatronics engineers when dealing with robots in a safe and interactive manner. And the third provides valuable guidance for industry and robotic based manufacturing, allowing a better view and simulating conditions otherwise inaccessible.
Prevalence of Transferable OXA-1 β-Lactamase Associated with Carbapenem-Resistant Klebsiella pneumoniae Isolates in Iraq
Authors: Abbas Fatima Moeen
Published: June 2021

This study was designed to explore the incidence of blaOXA-1 amongst Klebsiella pneumoniae isolates with resistant to carbapenem. Between December 2014 and April 2015, one hundred samples were taken from two hospitals: Babylon Teaching Hospital for Maternity and Pediatric / Babylon Province (clinical, umbilical infections, n= 40; environmental, n=20) and Karbala Hospital for Pediatric / Karbala Province (40 stool samples). All patients were hospitalized or attended these hospitals, all under 1 year of age. Seventeenth (17%) isolates were identified as Klebsiella pneumoniae. The antibiotic resistance profile of isolates was tested using disk diffusion method. High-level of resistance was recorded with ampicillin (94.1%) and piperacillin (88.2%) antibiotics. Resistance to carbapenem was reported in two K.pneumoniae isolates, these were investigated for the existence of OXA-1β-lactamase using Polymerase Chain Reaction (PCR) technique. Two (100%) isolates gave positive result. Transference of this gene was studied by conjugation experiment. The blaOXA-1 gene conjugated successfully in 1 (50%) isolate only.