bluuebunny/crossref_metadata_2025 huggingface dataset:
Carcass Traits, Organ Proportion and Bio-Economic Cost Benefits Analysis of Broiler Chickens Fed Different Dietary Plant Protein Sources in Sorghum-Based Diet
Authors: Agida C. A. , Onunkwo D. N. , Ezenyilimba B. N. , Afam-Ibezim E. M. , Ukonu A. B. , John U. E. , Adje C. I.
Published: November 2021

A 56-day study was carried out to evaluate the carcass characteristics and organ proportions of broiler chickens fed sorghum-based diets with varying plant protein. A total of 120 day-old broiler chickens from a reputable and disease free farm were used for this study. There were four treatments, each having thirty broiler birds replicated thrice with ten broiler birds per replicate using a Completely Randomized Design (CRD). The broiler birds were offered feed and water ad libitum. The growth parameters were taken on weekly basis. Carcass evaluation was carried out at the end of the trial. One bird per replicate was randomly selected, fasted over-night and slaughtered by severing the jugular vein. After scalding in warm water for about a minute, the feathers were manually plucked, each bird was cut into parts for carcass evaluation. The relative weights of the cut parts were as a percentage of dressed weight. The internal organs, such as heart, kidney, gizzard/proventriculus were all weighed separately and recorded using electric micrometer (3000g weighing gauge). The findings from this study showed that all the carcass parameters considered showed significant differences (p<0.05). Birds fed diet 3 gave the best live weight, slaughtered weight, defeathered weight, dressed weight and commensurate cut-parts. Soybean (whether cake or full-fat) demonstrate superiority over groundnut cake and cashew nut cake. Birds fed diet 3 gave the highest value of thigh, breast -cut, drumstick and wings, while birds fed diets 2, 1 and 4 gave less. The organ proportions of broiler chickens fed different dietary plant sources have all the parameters significantly difference (p<0.05), except the lungs though without any definite pattern. Average weight gain and feed conversion ratio were better (p<0.05) among birds fed diet 2, and 3. Cost benefits analysis per kilogram in naira terms for birds fed different plant protein sources in a sorghum-based diets were significant (p<0.05) among treatment levels. Least cost per kg feed was obtained in diet 1 (p<0.05). Cost of weight gained was (p<0.05) low in T1. Cost of feed consumed was low for diet T1 and T3. Revenue, gross margin and cost benefit ratio estimated were found to high (p<0.05) among T2 and T3. Broiler chickens fed diet 3 gave the best parameters. The actual contributions of the experiment, is to alternatively replace corn with sorghum completely at least cost with optimum performance.
Enfermedad de Pott. Reporte de caso clínico y revisión y bibliográfica
Authors: Corleto Molina Gabriela , López España Erza , González Morales Celeste
Published: November 2021

La tuberculosis es un problema sanitario importante en países en vías del desarrollo y la población pediátrica es un grupo susceptible.  La enfermedad de Pott provoca destrucción ósea, deformidad espinal y complicaciones neurales. Se presenta el caso de paciente femenina de 4 años y 5 meses con enfermedad de Pott, con destrucción de cuerpos vertebrales, deformidad ósea y paraparesias, en el departamento de Pediatría del Hospital Regional de Cobán, el diagnóstico se realizó clinicoradiológico acompañado de prueba de tuberculina positiva y GeneExpert positivo. Es necesario un diagnóstico temprano y el establecimiento de un tratamiento para un buen resultado.
Cambios en la angulación del plano oclusal y plano mandibular, al inicio y al final del tratamiento de ortodoncia en pacientes tratados de la Clínica de Maestría en Ortodoncia de la Facultad de Odontología de la Universidad de San Carlos de Guatemala dura
Authors: Jofre Ortiz Vilma Isabel , Argueta Hernández Bienvenido , Chinchilla Dubón Gerson Rudick
Published: November 2021

La inclinación del plano oclusal determina la posición mandibular, tendencia de crecimiento y relación esqueletal. El plano oclusal inclinado, hacia atrás y arriba, corresponde a clase II, en clase III, el ángulo es mas plano, promoviendo movimiento mandibular hacia adelante. El enfoque de tratamiento vertical promueve un movimiento mandibular para corregir los problemas dentoesqueletales. Objetivo: Analizar las diferencias que se manifiestan en el plano oclusal y plano mandibular al inicio y al final del tratamiento de ortodoncia y su correlación, según la relación esqueletal. Método: investigación analítica retrospectiva con una muestra de 47 sujetos, divididos según su relación esqueletal, Clase I= 25, Clase II = 15 y Clase III =7. Resultados: Para la angulación del plano oclusal al inicio y final del tratamiento, utilizando t de student, se encontró diferencia significativa en clase I y II al inicio y al final, los clase III no presentaron diferencias. En el plano mandibular utilizando t de student, no se presentaron diferencias en ninguno de los grupos. La correlación de Pearson de PO-PM/SN, encontró correlación en las radiografías iniciales de clase I, II y III y en los casos clase I al final del tratamiento. Para analizar la relación en los casos con o sin extracciones, se utilizó un ANOVA factorial, donde no se encontraron diferencias estadísticamente significativas en ninguno de los grupos. Conclusión: El tratamiento con enfoque anteroposterior, como los realizados en este estudio, produce cambios a nivel oclusal en las relaciones clase I y II.
Memoria Acción Educativa
Authors: Reynoso Tavico Timotea Viviana
Published: November 2021

La presente reseña detalla acciones fundamentales dentro del proceso y hecho educativo que coadyuvaran la administración de cualquier centro educativo del sector oficial, privado o municipal del sistema educativo nacional; sin descartar el nivel superior, principalmente cuando los retos y desafíos por llevar y generar cambios significativos en los contextos más vulnerables de la nación guatemalteca. Especialmente con las diferentes problemáticas que a diario aquejan a una población mayoritaria al vivir en resiliencia desde diversas exceptivas de la vida. De igual forma el Maestro Afre comparte diversas experiencias de liderazgo al encauzar al personal a cargo, a fin de dirigir a un elemento importante del proceso de formación “los docentes”, como entes indispensables que facilitan el aprendizaje de los estudiantes a cargo.
Por lo cual es de suma importancia tomar como referencia de las memorias de acción educativa, al proporcionar una serie reflexiones y acciones congruentes y pertinentes a la realidad nacional, especialmente con las secuelas que provocó la pandemia COVID-19 ante los desafíos actuales del proceso educativo de la nación; por lo que es indispensable orientar al administrador educativo y docentes de cualquier nivel de educación a tener conciencia, creatividad y humanidad para fomentar el aprendizaje; sino también el desaprender a fin de crear un verdadero ideal de formación, acorde a las necesidades, demandas y realidades del entorno social actual y propiciar mejoras a beneficio del bien común de la sociedad guatemalteca.
Sepsis Code: dodging mortality in a tertiary hospital
Authors: Méndez Rosa , Figuerola Angels , Chicot Marta , Barrios Ana , Pascual Natalia , Ramasco Fernando , Rodríguez Diego , García Íñigo , von Wernitz Andrés , Zurita Nelly , Semiglia Auxiliadora , Jiménez David , Navarro Sara , Rubio María José Rubio , Vinuesa Mercedes , del Campo Lourdes , Bautista Azucena , Pizarro Alberto
Published: November 2021

Background. In the hospital of La Princesa, the “Sepsis Code” (CSP) began in 2015, as a multidisciplinary group that provides health personnel with clinical, analytical and organizational tools, with the aim of the detection and early treatment of patients with sepsis. The objective of this study is to evaluate the impact of CSP implantation on mortality and to determine the variables associated with an increase in it. Material and methods. A retrospective analytical study of patients with CSP alert activation from 2015 to 2018 was conducted. Clinical-epidemiological variables, analytical parameters, and severity factors such as admission to critical care units (UCC) and the need for amines were collected. Statistical significance was established at p < 0.05. Results. We included 1,121 patients. The length of stay was 16 days and 32% required admission to UCC. Mortality showed a statistically significant linear downward trend from 24% in 2015 to 15% in 2018. The predictive mortality variables with statistically significant association were lactate > 2 mmol/L, creatinine > 1.6 mg/dL and the need for amines. Conclusions. The implementation of Sepsis Code decreases the mortality of patients with sepsis and septic shock. The presence of a lactate > 2 mmol/L, creatinine > 1.6 mg/dL and/or the need to administer amines in the first 24 hours, are associated with an increase in mortality in the patient with sepsis.
COVID 19 The pandemic and Price Volatility: An Analysis of Hospitality Industry in Emerging Market Economy - Case Study of Tanzania
Authors: Ntacho Gloria A , Muba Seif
Published: November 2021

Hotel industries have had the most impact in most of the countries as people went into lockdowns and quarantines as a result of the COVID-19 pandemic. The study aimed at assessing the degree of price change in relation to the profit of hotels before and during the COVID-19 pandemic. Tanzania has been considered to represent developing countries that have taken a different course in a fight against the pandemic. Price movement determines the reaction from customers and therefore performance. This study prepared to identify the knowledge gap on how supply shocks affecting prices of hotels caused by COVID-19 pandemic that are beyond control, especially on a developing country like Tanzania could have on the performance of hotels and whether the recovery of such recession can be predicted in the short run. Movement in supply, demand and management strategies were regarded as an indicator of the direction of the performance of hotels in Tanzania pre and during the COVID-19 pandemic period. The study adopted both qualitative and quantitative analysis for a period of two years, 2019 to 2021, for a sample of two hotels in Dar es salaam which are 5- star hotels. Focus group discussion was used as a way to collect data along with secondary data. The regression analysis has been adopted to analyse secondary data after considering the correlation between variables in the study. Performance of hotels was measured using daily demand generated in pre and during the pandemic period against changes in prices influenced by COVID-19 pandemic. The study found out that the influence of price movement during the pandemic period was not significant enough to have led to the deteriorating performance of hotels in Tanzania. However, hotel performance deteriorated as a result of other contributing factors such as a fall in occupancy rate, lack of markets and increasing additional costs to fight against the pandemic, supply shocks which led to a fall in efficiency. It was evidenced that this was highly triggered by the overdependence of hotels on foreign markets. Travelling restrictions and lockdowns cultivated the deteriorating performance in hotels even though Tanzania never went into lockdown. However, hotel management adopted measures to contain the impacts through various ways, such as cutting down costs and revising prices. The study concluded and recommended that Tanzania hotels management should adopt flexible strategies on pricing that would accommodate unprecedented events that are beyond the control of the market forces (demand and supply). This would enable management to have decisions that reflect the condition in the country and not get influence from companies within the group situated in other countries.
Future incidence and mortality of colorectal carcinoma in the United States: an updated overview of risk factors and preventative measures
Authors: Ali Hassam
Published: November 2021

According to the Global Cancer Observatory (GLOBOCAN) 2020, colorectal carcinoma (CRC) was the second leading cause of cancer death globally. Current literature utilizes reported databases such as Surveillance, Epidemiology, and End Results (SEER) to better understand the epidemiology of CRC. The global cancer observatory’s “Cancer Tomorrow” data visualization tools was used to predict the future incidence and mortality of colorectal cancers until 2030 as a guided tool to look over ways to reduce incidence by controlling risk factors of CRC. The total number of CRC is expected to rise by 2030, with a percent change of 17.3%. The expected percent change in colon cancer is more than rectal cancer (19.8% vs. 11.6%). The estimated number of deaths secondary to CRC is expected to increase in 2030, an estimated percent change of 22.2%. The incidence and mortality rate was higher in men vs. women; however, the gap seems to be closing on trend analysis. Major risk factors for CRC include familial syndromes, family history, race, gender, obesity, diet, alcohol, and smoking. Risk can be reduced by exercise and dietary changes, fiber intake, vitamin D, calcium, and minerals. Individualized screening based on age, gender, and additional risk factors could be an option that needs further comparative data to propose a definitive benefit over established screening guidelines.
THE PHILOSOPHY OF EDUCATION IN THE STRUCTURE OF SCIENTIFIC KNOWLEDGE
Authors:   Omsk state agrarian University, Kenispaev Zh.К. , Serova N. C. ,   Altai state pedagogical University, Davlatmurodov Sh. Sh. ,   Altai state pedagogical University
Published: November 2021

Since its inception, philosophy has been interested in the issues of education and upbringing of a person, the formation of his spiritual values. A striking example of this trend is the work of such ancient thinkers as Socrates, Plato and Aristotle. But as an independent branch of knowledge, the philosophy of education has emerged relatively recently. The article examines the problem field of the philosophy of education, the issues of its genesis and development, and also analyzes the place and role of the philosophy of education in the structure of modern scientific knowledge.
INDEPENDENT WORK AS THE MAIN DIRECTION OF DEVELOPMENT OF THE MODERN PARADIGM OF EDUCATION
Authors:   Altai State Agrarian University, Lesnykh E. A. , Solonko E. V. ,   Altai State Agrarian University
Published: November 2021

The paper considers the importance of independent work in the development of the modern paradigm in education. The main opportunities for the development of independent work of students in an effective way are noted. The main difficulties of performing independent work among students and teachers are highlighted. The results of research on the level of independent work performance are presented.
PATRIOTISM IN THE XXI CENTURY
Authors:   Altai State Pedagogical University, Markin V. V.
Published: November 2021

The article is devoted to the problem of the formation of patriotism in the realities of modern Russian society.
CULTURAL COMPONENT OF PEDAGOGICAL AND MANAGERIAL ACTIVITIES IN THE EDUCATION SYSTEM
Authors:   Altai State Pedagogical University, Novikova N. V.
Published: November 2021

The article reveals the socio-cultural foundations of the transformation of modern education. The relevance of the study of the cultural, cultural and creative component of the activities of teachers and heads of educational organizations is justified. A generalized analysis of research on the professional study of culture and its phenomena, communicative culture, and communication is presented. The place and role of communicative culture in pedagogical activity are marked.
IMPROVING THE HEALTH OF YOUNG PEOPLE WITH THE HELP OF GAMING SPORTS (FOR EXAMPLE, BASKETBALL)
Authors:   Altai State Medical University, Blazhko A.V. , Polotnyanko K. E. ,   Altai State Medical University, Terentyev M. S. ,   Altai State Medical University
Published: November 2021

The article discusses the problem of introducing students to a healthy lifestyle (HLS) through physical culture and health-improving practices in physical culture and sports (section) activities of students of a medical university. An important role in this process of playing sports, among which basketball is widespread, is shown. A general characteristic of basketball in the structure of the university discipline “physical culture” is given, its importance in organizing healthy lifestyles among students and for strengthening the health of a future doctor is shown.
PROFESSIONAL-ORIENTED APPROACH IN UNIVERSITY PEDAGOGY ON THE EXAMPLE OF PHYSICAL CULTURE AND SPORTS
Authors:   Altai State Medical University, Vorontsov P. G.
Published: November 2021

The author of the article proposes the development and implementation of a professionally oriented approach in higher education into the pedagogy of higher education. The professionally oriented approach provides for such a specialization of the general humanitarian, physical culture and natural science training of students, in which professional guidelines, theoretical and practical knowledge constructs, necessary for a future specialist in the field of activity being mastered, will be laid in the corresponding academic disciplines. A professionally oriented approach, on the one hand, based on general knowledge, gives a number of skills necessary in a future profession, and on the other hand, develops an additional interest in general educational disciplines in students due to the understanding that, in addition to the general outlook and development of the person, they they are also needed in their future profession. In the article, the professionally-oriented approach proposed by the author is considered on the example of physical culture and sports training of future teachers and coaches in physical culture and sports on the basis of pedagogical and physical education universities, which requires an art teacher to link his own academic discipline with the work profile of the university in which the teaching is conducted.
THE PROBLEM OF STIGMATIZATION AND ROMANTIZATION OF AUTISTIC SPECTRUM DISORDERS
Authors:   Moscow State Pedagogical University, Zinchenko E.D. , Nikandrova T.S. ,   Moscow State Pedagogical University
Published: November 2021

The article discusses the main problems of the phenomena of stigmatization and romanticization as aspects of society’s attitude towards persons with autism spectrum disorders. A survey in the form of a survey, reflecting the average indicators of the attitude of society towards people with autism, the presence of the respondents’ knowledge of the disorder.
ANTHROPOSOCIAL EVOLUTION AND DEVOLUTION – OPPOSITE VECTORS OF BEING AND EDUCATION
Authors:   Altai State Medical University, Ushakova E. V. , An S. A. ,   Altai State Pedagogical University
Published: November 2021

The article presents an analysis of modern opposing concepts and ways of transforming a person and society. One group of concepts, reflecting the progressive evolution of man and society (Darwinism), was considered the most recognized in science until the end of the twentieth century. It proves the general progressive path of anthroposociogenesis. But since the second half of the twentieth century and at present, another, opposite group of concepts has become increasingly popular: devolution, or regressive ways of changing a person and society. According to her, anthroposocial life reaches a certain limit of development, and then there is a reverse process of degradation and primitivization up to the primitive forms of anthropoids and their social organization. The problem is considered in relation to education. The important role of education as personality perfection in these opposite processes is shown. It is substantiated that the primitivization and devaluation of education (training and upbringing) in modern society leads to the replacement of the vectors of anthropo-social transformations from progressive to regressive.
OPPORTUNITIES FOR OVERCOMING THE ART CRISIS THROUGH THE INTERNET: STATEMENT OF THE PROBLEM
Authors:   Altai State Pedagogical University, An S.A.
Published: November 2021

The article identifies the functions of art on the Internet, special attention is paid to the educational function. The ways of self-expression and popularization of personality through professional and amateur creativity in the field of art on the Internet are considered. Art is seen as an element of modern mass culture. The emerging possibilities of overcoming the crisis of art through the Internet are analyzed. Keywords: art, personality, Internet, information, mass culture, creativity, amateurism, self-affirmation,
Number to me, space to you: Joint representation of spatial-numerical associations
Authors: D’Ascenzo Stefania , Fischer Martin H. , Shaki Samuel , Lugli Luisa
Published: November 2021

Recent work has shown that number concepts activate both spatial and magnitude representations. According to the social co-representation literature which has shown that participants typically represent task components assigned to others together with their own, we asked whether explicit magnitude meaning and explicit spatial coding must be present in a single mind, or can be distributed across two minds, to generate a spatial-numerical congruency effect. In a shared go/no-go task that eliminated peripheral spatial codes, we assigned explicit magnitude processing to participants and spatial processing to either human or non-human co-agents. The spatial-numerical congruency effect emerged only with human co-agents. We demonstrate an inter-personal level of conceptual congruency between space and number that arises from a shared conceptual representation not contaminated by peripheral spatial codes. Theoretical implications of this finding for numerical cognition are discussed.
Investigation of Applicability of Additive Manufacturing Processes to Appropriate Technologies for Developing Countries
Authors: Ahn Dong-Gyu
Published: November 2021

In recent years, additive manufacturing (AM) processes have emerged as an important manufacturing technology for a multi-item small sized production to lead the 4th industrial revolution. The layer-by-layer deposition characteristics of AM process can rapidly produce physical parts with three-dimensional geometry and desired functionality in a relatively low cost environment. The goal of this paper is to investigate the applicability of AM process to appropriate technologies for developing countries. Through the review of examples of appropriate technology of the AM process, the possibility of a practical usage of the AM process for the appropriate technologies is examined. In addition, significant applications of the AM process to the appropriate technology are introduced. Finally, future issues related to production of physical parts for developing countries using the AM process are discussed from the viewpoint of the appropriate technology.
The role of biased calcium-sensing receptor signalling in urinary calcium excretion and kidney stone disease
Authors: Goldsworthy Michelle
Published: November 2021

Michelle Goldsworthy1,2, Asha Bayliss2, Anna Gluck2, Akira Wiberg3, Benjamin Turney1, DominicFurniss3, Rajesh Thakker2, Sarah Howles1,2

1Nuffield Department of Surgical Sciences, University of Oxford, United Kingdom.2Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, UnitedKingdom.3Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Universityof Oxford, United Kingdom.

Nephrolithiasis is a major health burden with a poorly understood pathogenesis. We conducteda genome-wide association study in British and Japanese populations identifying twentynephrolithiasis-associated loci. Mutations in the calcium-sensing receptor (CaSR) causedisorders of calcium homeostasis and five identified loci (DGKD, DGKH, WDR72, GPIC1 and BCR)were predicted to influence CaSR-signalling.

In a validation population, we demonstrated that genotype at the DGKD-associated locuscorrelated with urinary calcium excretion but not serum calcium concentration. In vitro studiesdemonstrated that knockdown and overexpression of DGKD resulted in biased CaSR-signalling.Thus, treatment of CaSR-expressing HEK cells with DGKD-targeted siRNA (DGKD-KD), resulted indecreased MAPK responses to alterations in extracellular calcium concentration [Ca2+]e, asassessed by SRE-reporter and ERK-phosphorylation (pERK) assays, when compared to cellstreated with scrambled siRNA (WT) but without alteration in intracellular calcium responses[Ca2+]i as assessed by NFAT-reporter and Fluo-4 calcium assays (SRE maximal response DGKD-KD=5.28 fold change vs. WT=7.20 p=0.0065, pERK maximal response DGKD-KD=24.77, vs. WT=39.46 fold change, p=0.0056). Conversely, DGKD overexpression (DGKD-OE) increased MAPKresponses but suppressed [Ca2+]i responses to alterations in [Ca2+]e (SRE maximal responseDGKD-OE =14.13 fold change vs. WT=9.06 fold change, p=0.01; NFAT maximal response DGKDOE=13.67 fold change vs WT=59.16 fold change, p=0.0001).

Our results demonstrate that alterations in DGKD expression cause biased CaSR-signalling. Thisbiased signalling may provide an explanation for the correlation of genotype at the DGKDassociatedlocus with urinary calcium excretion but not serum calcium concentration. Ourfindings suggest that biased CaSR-signalling may be a common cause of nephrolithiasis.
Retrospectiva știrilor false asupra evenimentelor din regiunea transnistreană din anul 1992: abordări comparative / Retrospective of false news on events in the Transnistrian region since 1992: comparative approaches
Authors: Enachi Valentina
Published: November 2021

The analysis of the problem of false news and other media constructions is based on quantitative research, which shows the distribution of published materials in Chisinau and the Russian Federation. In these media, the materials addressed the topics regarding the events on the Dniester in 1992 in a negative, neutral or positive way. The qualitative research aims to describe the content of the articles divided into separate thematic blocks, sub-themes, and representation sections. The media construction of the events of the Dniester War in 1992 in the written and online press in the Republic of Moldova is contradictory. The Russian press and the left-wing press contribute to the false and erroneous perception that the phenomenon is known as „Transnistrian conflict” is a civil one, and that it is not Russia but Transnistria that is a „party” to the conflict, that Russia has the status of a neutral mediator and guarantor of the agreements between the parties
and the provisions of the Memorandum on normalizing relations between the Republic of Moldova and Transnistria signed in 1997 in Moscow.
Suveranitatea Republicii Moldova între război şi pace / Sovereignty of the Republic of Moldova between war and peace
Authors: Catan Victor
Published: November 2021

This article is dedicated to the analysis of the premises, causes, content and impact of the 1992 war to defend the independence and territorial integrity of the Republic of Moldova, the effect of the Moldovan-Russian Agreement of 21.07.1992 on the principles of peaceful settlement of the armed conflict in the Transnistrian region of Moldova. The paper presents the chronology of historical and geopolitical events related to Bessarabia, annexed in 1812 by the Russian Empire, occupied by the Red Army of the USSR according to the Ribbentrop-Molotov Pact of August 1939, was subject to armed rebellion in 1990-1992, period of disintegration. of the Soviet Union and the self-determination of the Republic of
Moldova as a sovereign and independent state.
Escaladarea conflictelor regionale în spațiul post-sovietic. Cazul conflictului transnistrean / Escalation of regional conflicts in the post-Soviet space. The case of the Transnistrian conflict
Authors: Melintei Mihai
Published: November 2021

The last decade of the twentieth century was marked by a geopolitical event with long-lasting effects - the collapse of the Union of Soviet Socialist Republics. One of the „poles” of the bipolar system of international relations has completely disappeared, and its fragments have begun to move in different directions - the independent states of the post-Soviet space have begun to form. Thus, the adaptation of the independent states from the
post-Soviet space to the new geopolitical realities and the determination of their own political and external development vector began. At the same time, nationalist forces intensified and political tensions increased, leading to regional conflicts, especially in the vast Black Sea basin.
Follow-up Photometry in Another Band Helps to Reduce Kepler’s False-positive Rates
Authors: Wang 王 Mu-Tian 牧天 , Liu Hui-Gen , Zhu Jiapeng , Zhou Ji-Lin
Published: November 2021

The Kepler mission’s single-band photometry suffers from astrophysical false positives, most commonly of background eclipsing binaries (BEBs) and companion transiting planets (CTPs). Multicolor photometry can reveal the color-dependent depth feature of false positives and thus exclude them. In this work, we aim to estimate the fraction of false positives that cannot be classified by Kepler alone but can be identified from their color-dependent depth feature if a reference band (z, K

s
, and Transiting Exoplanet Survey Satellite (TESS)) is adopted in follow-up observation. We construct physics-based blend models to simulate multiband signals of false positives. Nearly 65%–95% of the BEBs and more than 80% of the CTPs that host a Jupiter-sized planet will show detectable depth variations if the reference band can achieve a Kepler-like precision. The K

s
band is most effective in eliminating BEBs exhibiting features of any depth, while the z and TESS bands are better for identifying giant candidates, and their identification rates are more sensitive to photometric precision. Given the radius distribution of planets transiting the secondary star in binary systems, we derive a formalism to calculate the overall identification rate for CTPs. By comparing the likelihood distribution of the double-band depth ratio for BEB and planet models, we calculate the false-positive probability (FPP) for typical Kepler candidates. Additionally, we show that the FPP calculation helps distinguish the planet candidate’s host star in an unresolved binary system. The framework of the analysis in this paper can be easily adapted to predict the multicolor photometric yield for other transit surveys, especially TESS.
Enhanced Kozai–Lidov Eccentricity Oscillations in Nuclear Star Clusters
Authors: Haas Jaroslav , Šubr Ladislav
Published: November 2021

Stellar motions in the innermost parts of galactic nuclei, where the gravity of a supermassive black hole dominates, follow Keplerian ellipses to the first order of approximation. These orbits may be subject to periodic (Kozai–Lidov) oscillations of their orbital elements if some nonspherically distributed matter (e.g., a secondary massive black hole, coherent stellar subsystem, or large-scale gaseous structure) perturbs the gravity of the central supermassive black hole. These oscillations are, however, affected by the overall potential of the host nuclear star cluster. In this paper, we show that its influence strongly depends on the properties of the particular system, as well as the considered timescale. We demonstrate that for systems with astrophysically relevant parameters, the Kozai–Lidov oscillations of eccentricity can be enhanced by the extended potential of the cluster in terms of reaching significantly higher maximal values. In a more general statistical sense, the oscillations of eccentricity are typically damped. The efficiency of the damping, however, may be small to negligible for the suitable parameters of the system. This applies, in particular, in the case when the perturbing body is on an eccentric orbit.
Systematic Perturbations of the Thermodynamic Properties in Cool Cores of HIFLUGCS Galaxy Clusters
Authors: Ueda Shutaro , Umetsu Keiichi , Ng FanLam , Ichinohe Yuto , Kitayama Tetsu , Molnar Sandor M.
Published: November 2021

We present an ensemble X-ray analysis of systematic perturbations in the central hot gas properties for a sample of 28 nearby strong cool-core systems, selected from the HIghest X-ray FLUx Galaxy Cluster Sample (HIFLUGCS). We analyze their cool-core features observed with the Chandra X-ray Observatory. All individual systems in our sample exhibit at least a pair of positive and negative excess perturbations in the X-ray residual image after subtracting the global brightness profile. We extract and analyze X-ray spectra of the intracluster medium (ICM) in the detected perturbed regions. To investigate possible origins of the gas perturbations, we characterize thermodynamic properties of the ICM in the perturbed regions and characterize their correlations between positive and negative excess regions. The best-fit relations for temperature and entropy show a clear offset from the one-to-one relation,

T

neg

/

T

pos

=

1.20

−
0.03

+
0.04

and K
neg/K
pos = 1.43 ± 0.07, whereas the best-fit relation for pressure is found to be remarkably consistent with the one-to-one relation P
neg = P
pos, indicating that the ICM in the perturbed regions is in pressure equilibrium. These observed features in the HIFLUGCS sample are in agreement with the hypothesis that the gas perturbations in cool cores are generated by gas sloshing. We also analyze synthetic observations of perturbed cluster cores created from binary merger simulations, finding that the observed temperature ratio agrees with the simulations, T
neg/T
pos ∼ 1.3. We conclude that gas sloshing induced by infalling substructures plays a major role in producing the characteristic gas perturbations in cool cores. The ubiquitous presence of gas perturbations in cool cores may suggest a significant contribution of gas sloshing to suppressing runaway cooling of the ICM.
The Supersonic Project: SIGOs, A Proposed Progenitor to Globular Clusters, and Their Connections to Gravitational-wave Anisotropies
Authors: Lake William , Naoz Smadar , Chiou Yeou S. , Burkhart Blakesley , Marinacci Federico , Vogelsberger Mark , Kremer Kyle
Published: November 2021

Supersonically induced gas objects (SIGOs), are structures with little to no dark-matter component predicted to exist in regions of the universe with large relative velocities between baryons and dark matter at the time of recombination. They have been suggested to be the progenitors of present-day globular clusters. Using simulations, SIGOs have been studied on small scales (around 2 Mpc) where these relative velocities are coherent. However, it is challenging to study SIGOs using simulations on large scales due to the varying relative velocities at scales larger than a few Mpc. Here, we study SIGO abundances semi-analytically: using perturbation theory, we predict the number density of SIGOs analytically, and compare these results to small-box numerical simulations. We use the agreement between the numerical and analytic calculations to extrapolate the large-scale variation of SIGO abundances over different stream velocities. As a result, we predict similar large-scale variations of objects with high gas densities before reionization that could possibly be observed by JWST. If indeed SIGOs are progenitors of globular clusters, then we expect a similar variation of globular cluster abundances over large scales. Significantly, we find that the expected number density of SIGOs is consistent with observed globular cluster number densities. As a proof-of-concept, and because globular clusters were proposed to be natural formation sites for gravitational wave sources from binary black-hole mergers, we show that SIGOs should imprint an anisotropy on the gravitational wave signal on the sky, consistent with their distribution.
Are Massive Dense Clumps Truly Subvirial? A New Analysis Using Gould Belt Ammonia Data
Authors: Singh Ayushi , Matzner Christopher D. , Friesen Rachel K. , Martin Peter G. , Pineda Jaime E. , Rosolowsky Erik , Alves Felipe , Chacón-Tanarro Ana , Chen Hope How-Huan , Chen Michael Chun-Yuan , Choudhury Spandan , Di Francesco James , Keown Jared , Kirk Helen , Punanova Anna , Seo Youngmin , Shirley Yancy , Ginsburg Adam , Offner Stella S. R. , Arce Héctor G. , Caselli Paola , Goodman Alyssa A. , Myers Philip C. , Redaelli Elena ,   The GAS Collaboration
Published: November 2021

Dynamical studies of dense structures within molecular clouds often conclude that the most massive clumps contain too little kinetic energy for virial equilibrium, unless they are magnetized to an unexpected degree. This raises questions about how such a state might arise, and how it might persist long enough to represent the population of massive clumps. In an effort to reexamine the origins of this conclusion, we use ammonia line data from the Green Bank Ammonia Survey and Planck-calibrated dust emission data from Herschel to estimate the masses and kinetic and gravitational energies for dense clumps in the Gould Belt clouds. We show that several types of systematic error can enhance the appearance of low kinetic-to-gravitational energy ratios: insufficient removal of foreground and background material; ignoring the kinetic energy associated with velocity differences across a resolved cloud; and overcorrecting for stratification when evaluating the gravitational energy. Using an analysis designed to avoid these errors, we find that the most massive Gould Belt clumps harbor virial motions, rather than subvirial ones. As a by-product, we present a catalog of masses, energies, and virial energy ratios for 85 Gould Belt clumps.
M17 MIR: A Massive Protostar with Multiple Accretion Outbursts
*
Authors: Chen 陈 Zhiwei 志维 , Sun 孙 Wei 玮 , Chini Rolf , Haas Martin , Jiang 江 Zhibo 治波 , Chen 陈 Xuepeng 学鹏
Published: November 2021

We report the discovery of a massive protostar M17 MIR embedded in a hot molecular core in M17. The multiwavelength data obtained during 1993–2019 show significant mid-IR (MIR) variations, which can be split into three stages: the decreasing phase during 1993.03–mid-2004, the quiescent phase from mid-2004 to mid-2010, and the rebrightening phase from mid-2010 until now. The variation of the 22 GHz H2O maser emission, together with the MIR variation, indicates an enhanced disk accretion rate onto M17 MIR during the decreasing and rebrightening phases. Radiative transfer modeling of the spectral energy distributions of M17 MIR in the 2005 epoch (quiescent) and 2017 epoch (accretion outburst) constrains the basic stellar parameters of M17 MIR, which is an intermediate-mass protostar (M
* ∼ 5.4 M
⊙) with

M

̇

acc

∼
1.1
×

10

−
5

M

⊙

yr

−
1

in the 2005 epoch and

M

̇

acc

∼
1.7
×

10

−
3

M

⊙

yr

−
1

in the 2017 epoch. The enhanced

M

̇

acc

during outburst induces the luminosity outburst ΔL ≈ 7600 L
⊙. In the accretion outburst, a larger stellar radius is required to produce

M

̇

acc

consistent with the value estimated from the kinematics of H2O masers. M17 MIR shows two accretion outbursts (Δt ∼ 9–20 yr) with outburst magnitudes of about 2 mag, separated by a 6 yr quiescent phase. The accretion outburst occupies 83% of the time over 26 yr. The accretion rate in outburst is variable with amplitude much lower than the contrast between quiescent and outburst phases. The extreme youth of M17 MIR suggests that minor accretion bursts are frequent in the earliest stages of massive star formation.
Monitoring the reduction and maintenance of periprosthetic bone tissue in cementless primary hip endoprosthesis with alendronate therapy
Authors: Shabani Ilir , Samardziski Milan , Kamnar Viktor , Popovski Neron , Gavrilovski Antonio , Memeti Shaban
Published: November 2021

Loss of periprosthetic bone tissue in primary hip endoprostheses is common in clinical practice. This loss can be progressive and in extreme conditions can jeopardize the longevity of the prosthesis. In order to monitor the function of Alendronate therapy for bone maintenance, the study included 50 patients with implanted total cement-free hip endoprosthesis (TPH). The first group of 25 patients received Alendronate, calcium and vitamin D3 orally postoperatively. The second group of 25 patients were examined postoperatively without therapy. Patients were followed by radiographic and dual-energy X-ray absorptiometry (DXA) at 6 and 12 months. The study showed that in patients with TPH there was a difference in the X-ray findings as well as occurrence of osteolysis in certain Gruen zones, which was confirmed by changes in the state of bone mineral density (BMD) and bone mineral content (BMC) in the interval between 6 and 12 months using the DXA method. Alendronate therapy after TPH implantation allows reduction of periprosthetic bone mass loss, maintenance of bone mineralization and implant hardening.
Diabetes mellitus and hypertensive cerebral hemorrhage.
Authors: Pangovski Ivan
Published: November 2021

Diabetes mellitus is an increasingly common public health problem and affects the population health. In many studies, DM is very often in a close correlation with many cardiovascular diseases and brain hemorrhage in general. The aim of the paper was to determine whether the presence of diabetes mellitus has influence on the occurrence of cerebral hemorrhage. Material and methods: The study included 61 patients diagnosed with hypertensive intracerebral hematoma in the hemispheres of the brain. Results: The prevalence of diabetes in the group of survivors of intracerebral hemorrhage was 26.67%, while in the group of subjects in whom the disease ended lethally diabetes had an insignificantly higher prevalence of 43.75% (Chi-square: 1.61df = 1, p = 0.21). Analysis of the prevalence of diabetes regarding the mobility of the respondents showed that there were no respondents with diabetes in the group of patients who could function independently, while there were 7 (24.14%) respondents with diabetes in the group who required help or aid for accomplishing their daily activities, and 5 (50%) in the group of respondents who were completely dependent on someone else in performing the everyday functioning. Statistical analysis showed these differences as insufficient to be statistically confirmed as significant (Fisher exact test, p = 0.105). Conclusion: In patients who have had cerebral hemorrhage with lethal outcome diabetes mellitus is a very common phenomenon, as well as in patients who have survived but subsequently have decreased mobility. But these differences are not statistically significant. Measures for reduction of the incidence of diabetes mellitus are needed. These measures include early detection of the disease, treatment and prevention of disability.
The most common disorders of the hand associated with carpal tunnel syndrome in adults
Authors: Grujoska-Veta Dushanka , Georgieva Daniela , Atanasov Nenad , Shabani Ilir , Angeleska Liljana , Georgiev Antonio , Bogdanska Jasna
Published: November 2021

Carpal tunnel syndrome (CTS) is one of the most common peripheral neuropathies caused by chronic compression of the median nerve in the area of the carpal tunnel and its etiology is multifactorial. Trigger fingers and de Quervain’s disease are common disorders of the hand related to CTS in adults.Theaim of this study was to present the most common disorders of the hand such as stenosing tenosynovitis in adults with surgically treated CTS and to evaluate their demographic data.Material and methods: A total of 116 surgically treated patients with established diagnosis of CTS (clinically and by electrophysiological examination) were included in this prospective study, which was conducted at the University Clinic for Orthopedic Diseases in Skopje. Demographic data, findings of history of the disease and clinical examination were recorded and analyzed.Results: Participants with CTS included in the study were with a mean age of 55.41±10.7 years (age range 29-75). 75% of them were female. 63.8% of participants suffered from one or more comorbid chronic diseases. On admission to hospital, disorders such as trigger fingers and de Quervain’s disease were concomitantly diagnosed in 15.51% on ipsilateral hand with CTS. All disorders were surgically treated following open carpal tunnel release, as “one stage procedure”, under local anesthesia.Conclusion: Our findings have determined concomitant existence of CTS and stenosing tenosynovitis (trigger fingers and de Quervain’s disease) on ipsilateral hand, which suggests common etiological factors. Female gender and age range 40-60 years are major common factors related to these three disorders.
Evaluation of pediatric patients with јuvenile idiopathic arthritis treated with biological therapy Tocilizumab (Actemra)
Authors: Neskovska-Sumenkovska Marija , Sofijanova Aspazija , Kacarska Rozana , Kuzevska-Maneva Konstandina , Gjurkova Angelovska Beti , Jovanovska Valentina
Published: November 2021

Juvenile idiopathic arthritis (JIA) is the most common chronic disease in childhood. It manifests a heterogenic group of symptoms of arthritis, lasting at least 6 weeks and it appears before the age of 16. Patients who had no good therapeutic response to conventional therapy with Methotrexate were treated with biological therapy. The aim of this paper was to evaluate 9 patients who were receiving Tocilizumab at the Department of Rheumocardiology, University Clinic of Pediatric Diseases in Skopje. Materials and methods: Our study included 9 patients treated at our Department with biological therapy with Tocilizumab. Prior to initiation of the biological therapy, all patients underwent laboratory investigations, purified protein derivative (PPD) skin test for tuberculosis, X ray of the lungs and heart, and analysis of hepatitis markers. All patients were treated with amp. Actemra (tocilizumab) 8 mg/kg/tt i.v. Two of the patients had a severe form of the disease (one with severe systemic form and one with severe oligoarticular form of JIA). All presented patients had clinical remission of the disease. Conclusion: Therapy with tocilizumab in patients with juvenile idiopathic arthritis is a good therapeutic choice. The results obtained in our study have shown a significant therapeutic effect of tocilizumab even in severe forms of the disease.
Bronchial Asthma: Genetic Factors Contributing to its Pathogenesis
Authors: Krynytska Inna , Marushchak Mariya , Mykolenko Anna , Smachylo Iryna , Sopel Olha , Kucher Svitlana
Published: November 2021

Researching bronchial asthma (BA)-linked gene polymorphisms can help to clarify heterogeneity of the disease and estimate its severity, which, in turn, will aid in developing an appropriate treatment corresponding to the patient’s unique asthma pathogenesis. The aim of presented review is to analyze the published data on the genetic preconditions of BA and the possible role of different genes polymorphisms in its pathogenesis. We have found that despite the fact that numerous genes are involved in the pathogenesis of BA and their polymorphisms are associated with increased risks for BA, it is important to understand that a combination of factors, both genetic and environmental, triggers BA development and determines its progression. On the other hand, the identification of BA susceptibility genes contributing to asthma pathogenesis and treatment response is the first step toward the development of personalized medicine.