bluuebunny/crossref_metadata_2025 huggingface dataset:
Inflammation and Adverse Outcomes in Patients With Acute Ischemic Stroke With and Without Chronic Kidney Disease
Authors: Wang Xiaoyu , Pan Yuesong , Zhang Runhua , Wang Mengxing , Meng Xia , Li Zixiao , Li Hao , Wang Yilong , Zhao Xingquan , Wang Yongjun , Liu Gaifen
Published: April 2024

Background

Elevated white blood cell count, fibrinogen levels, and lower levels of albumin signify higher systemic inflammatory response, hypercoagulable state, and poorer nutritional status, respectively. However, a consistent conclusion could not be drawn on whether the association between inflammatory markers and cardiovascular disease was affected by the presence of chronic kidney disease (CKD). We aimed to explore the association between inflammation and adverse outcomes in patients with acute ischemic stroke (AIS), as well as whether this association differs due to the presence of CKD.

Methods and Results

This research was based on the Third China National Stroke Registry. The main adverse outcomes were poor functional outcome, stroke recurrence, and combined vascular event after 1 year. Inflammation was defined as the worst quartile of at least 2 of the aforementioned 3 markers. Finally, 8493 patients with AIS were enrolled in this study. The adjusted odds ratios/hazard ratios and 95% CIs of inflammation were 1.58 (1.34–1.86) for poor functional outcomes, 1.25 (1.06–1.47) for stroke recurrence, and 1.25 (1.06–1.46) for combined vascular event. The association between inflammation and adverse outcomes existed only in patients with AIS without CKD, although the interaction between CKD and inflammation was not statistically significant. (
P
for interaction >0.05).

Conclusions

Inflammation, which was defined as a combination of fibrinogen, white blood cell count, and albumin, was associated with all 1‐year adverse outcomes among patients with AIS. Routine assessment of these biomarkers could become a potential part of the clinical evaluation for patients with AIS, especially those without CKD, aiding clinicians in risk stratification and treatment decision‐making.
Do Deep Learning Algorithms Accurately Segment Intracerebral Hemorrhages on Noncontrast Computed Tomography? A Systematic Review and Meta‐Analysis
Authors: Zarei Diana , Issaiy Mahbod , Kolahi Shahriar , Liebeskind David S.
Published: April 2024

Background

Stroke, a major global health issue, is broadly categorized into ischemic and hemorrhagic types. The volume of hemorrhage on noncontrast computed tomography guides the treatment options and hints at prognosis. Conventional approaches to calculate intracerebral hemorrhage (ICH) volume, like the ABC/2 method, typically rely on an assumed standard shape and might be inaccurate. Advances in deep learning have significantly improved noncontrast computed tomography's capabilities in ICH volume estimation. This study conducts a comprehensive systematic review and meta‐analysis to evaluate the precision of deep learning algorithms in delineating ICH on noncontrast computed tomography.

Methods

A systematic review and meta‐analysis, adhering to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, was conducted on literature from 2000 to October 2023. Studies were selected on the basis of strict inclusion and exclusion criteria. Performance evaluation was done using the Dice Similarity Coefficient, and the Prediction Model Risk of Bias Assessment Tool was used for quality assessment. Statistical analysis was carried out using Stata 17.0.

Results

The review included 28 studies, mainly retrospective cohorts, with a focus on convolutional neural network architectures, particularly U‐Net variants. A meta‐analysis of 14 studies revealed a combined Dice Similarity Coefficient of 0.85 (95% CI, 0.82–0.88). Performance was consistent across various methodologies but varied on the basis of ICH pathogenesis, with spontaneous ICH having higher accuracy.

Conclusion

Deep learning models are highly effective in segmenting ICH on noncontrast computed tomography, demonstrating potential improvements in clinical neuroimaging. Despite their efficacy, challenges in segmenting smaller hemorrhages remain. The findings suggest that deep learning could reduce health care professional workloads and enhance patient care, although further research is needed to address limitations and extend clinical utility.
Arrival of crocodilians to São Tomé Island, Gulf of Guinea, Western Africa, highlights the role of sea currents to the natural colonization of islands
Authors: Ceríaco Luis M.P. , Barbosa Matheus R. , Sousa Ana Carolina A. , Santos Bruna S. , Perestrelo Sofia , Marques Mariana P.
Published: April 2024

Historical and recent arrivals of crocodilians to the Gulf of Guinean Oceanic Island of São Tomé have intrigued naturalists for several centuries. Here we present the revision of the historical records, and present data regarding the recent arrival of a single specimen in 2021. After being killed by the local authorities, the specimen was preserved and studied both through morphological and molecular methods. Our findings suggest that the specimen was a sub-adult Nile crocodile, Crocodylus niloticus Laurenti, 1768, which most likely drifted from the Congo or Ogooué river mouths in West Africa by the oceanic current acting on the Gulf of Guinea. The story of this individual highlights the dispersion paths that have contributed by the past biological colonization of São Tomé Island.
Perceived Audio-Visual Simultaneity Is Recalibrated by the Visual Intensity of the Preceding Trial
Authors: Horsfall Ryan , Harrison Neil , Meyer Georg , Wuerger Sophie
Published: April 2024

A vital heuristic used when making judgements on whether audio-visual signals arise from the same event, is the temporal coincidence of the respective signals. Previous research has highlighted a process, whereby the perception of simultaneity rapidly recalibrates to account for differences in the physical temporal offsets of stimuli. The current paper investigated whether rapid recalibration also occurs in response to differences in central arrival latencies, driven by visual-intensity-dependent processing times. In a behavioural experiment, observers completed a temporal-order judgement (TOJ), simultaneity judgement (SJ) and simple reaction-time (RT) task and responded to audio-visual trials that were preceded by other audio-visual trials with either a bright or dim visual stimulus. It was found that the point of subjective simultaneity shifted, due to the visual intensity of the preceding stimulus, in the TOJ, but not SJ task, while the RT data revealed no effect of preceding intensity. Our data therefore provide some evidence that the perception of simultaneity rapidly recalibrates based on stimulus intensity.
Taxonomy, ontogeny, and ecology of Tonnacypris stewarti (Daday 1908) comb. nov. (Ostracoda: Cyprididae) from Nam Co, Tibetan Plateau
Authors: BONILLA-FLORES MAURICIO , ECHEVERRÍA-GALINDO PAULA , FRENZEL PETER , PÉREZ LISETH , BÖRNER NICOLE , DULIAS KATHARINA , WANG JUNBO , SCHWALB ANTJE
Published: April 2024

Taxonomic clarification of Tonnacypris stewarti comb. nov. (= Herpetocypris stewarti), a non-marine ostracod first described by Daday in 1908, was required due to the existence of various synonyms without detailed morphological descriptions. Our study examined specimens from Mang-tsa, Nam Co (Tibetan Plateau) and Lake Band-e Amir (Afghanistan). We identified seven definitive synonyms (Herpetocypris stewarti Daday 1908, Ilyodromus estonicus Järvekülg 1960, Eucypris afghanistanensis Hartmann 1964, E. gyirongensis Yang 1982, E. rischtanica Schneider 1963 in Mandelstam & Schneider 1963, Tonnacypris estonica (Järvekülg 1960), and T. gyirongensis (Guo et al. 2016). After a detailed study of the morphology of valves and soft parts supplemented by a literature review, we propose combining the genus Tonnacypris with the specific epithet stewarti, resulting in the new name Tonnacypris stewarti. We documented the ontogenetic series of T. stewarti in surface sediment samples from Nam Co. Only female specimens were found, consistent with observations in Mongolia, where they were considered asexual populations. Sexual populations were reported from Afghanistan and the southern Tibetan Plateau, suggesting geographic parthenogenesis in the Palearctic region. Because of widely missing males, we explored the use of female genital lobes as a distinguishing feature for taxonomy. Considering current ecological knowledge, T. stewarti could serve as a (paleo)—bioindicator of cold, oligotrophic, and fresh to slightly brackish habitats, including rivers, lagoons, and lakes. This study emphasizes the importance of resolving taxonomic issues for future paleolimnological research. Moreover, our investigation highlights the potential use of sclerotized internal female genital lobes as distinctive characteristics for species differentiation, especially in asexual populations.
Analysis of Gender Paradigms in the West and the East: An Example of Visual Arts
Authors: Nargiza Alimova
Published: April 2024

The article focuses on the differences between Eastern and Western art, characteristics of the representation of women's images in Eastern and Western art, and aesthetic criteria regarding women's images in Eastern and Western art. The author emphasized the need to understand the image of women in Eastern and Western visual artworks in different cultural and historical contexts and concluded that studying the image of women in visual art can help one better understand regional gender paradigm differences. To understand the representation of women in Eastern and Western cultures, it is necessary to first understand the differences and similarities between these two cultures in order to gain a deeper understanding of how women are portrayed in these cultures. A few of the differences that can be found between East and West include the geographical structure, the ethno-cultural colors, the social outlooks, and the aesthetic ideals of the two regions. In addition to these factors, it is also important to consider how the visual arts of the two regions differ in their methods, materials, and religious, philosophical and philosophical perspectives. Throughout the article, the author discusses these aspects in great detail, showing specific approaches as to how the female image is represented in Eastern and Western visual art traditions. As such, the article provides valuable insight into the cultural divide between East and West and how their respective artistic styles have interacted with each other.
Deep Learning of a 200-Member Ensemble with a Limited Historical Training to Improve the Prediction of Extreme Precipitation Events
Authors: Ghazvinian Mohammadvaghef , Delle Monache Luca , Afzali Gorooh Vesta , Steinhoff Daniel , Sengupta Agniv , Hu Weiming , Simpson Matthew , Weihs Rachel , Papadopoulos Caroline , Mulrooney Patrick , Kawzenuk Brian , Mascioli Nora , Ralph Fred Martin
Published: April 2024

This study introduces a deep learning (DL) scheme to generate reliable and skillful probabilistic quantitative precipitation forecasts (PQPFs) in a postprocessing framework. Enhanced machine learning model architecture and training mechanisms are proposed to improve the reliability and skill of PQPFs while permitting computationally efficient model fitting using a short training dataset. The methodology is applied to postprocessing of 24-h accumulated PQPFs from an ensemble forecast system recently introduced by the Center for Western Weather and Water Extremes (CW3E) and for lead times from 1 to 6 days. The ensemble system was designed based on a high-resolution version of the Weather Research and Forecasting (WRF) Model, named West-WRF, to produce a 200-member ensemble in near–real time (NRT) over the western United States during the boreal cool seasons to support Forecast-Informdayed Reservoir Operations (FIRO) and studies of prediction of heavy-to-extreme events. Postprocessed PQPFs are compared with those from the raw West-WRF ensemble, the operational Global Ensemble Forecast System version 12 (GEFSv12), and the ensemble from the European Centre for Medium-Range Weather Forecasts (ECMWF). As an additional baseline, we provide PQPF verification metrics from a recently developed neural network postprocessing scheme. The results demonstrate that the skill of postprocessed forecasts significantly outperforms PQPFs and deterministic forecasts from raw ensembles and the recently developed algorithm. The resulting PQPFs broadly improve upon the reliability and skill of baselines in predicting heavy-to-extreme precipitation (e.g., >75 mm) across all lead times while maintaining the spatial structure of the high-resolution raw ensemble.
Is Routine Intraoperative Cholangiogram Necessary in Patients With Mild Acute Biliary Pancreatitis Undergoing Index Admission Cholecystectomy?
Authors: Quarmby Natalie M. , Vo Minh Tu , Gananadha Sivakumar
Published: April 2024

Background: There is controversy about whether intraoperative cholangiogram (IOC) should be performed routinely during laparoscopic cholecystectomy for patients with acute biliary pancreatitis, given significant false positive and negative rates and increased resource utilization. The aim of this study was to clarify the role of IOC in cases of mild biliary pancreatitis in patients undergoing index admission cholecystectomy, its impact on patient outcomes, and the impact of blood tests, imaging, and preoperative intervention on the detection of choledocholithiasis.

Methods: A retrospective review of all patients presenting with acute mild biliary pancreatitis between January 2006 and December 2019 was conducted. Data collected included patient demographics, serum chemistry, IOC, and Endoscopic Retrograde Cholangiopancreatography (ERCP) findings, imaging findings, length of stay, operative length, and long-term follow-up outcomes.

Results: 284 patients met the inclusion criteria for the study. The overall false positive IOC rate was 7.4%. Worsening bilirubin trend was a positive predictive value (PPV) for positive IOC and ERCP outcomes with a relative risk of 2.93 ( P < .01) and 2.32 ( P = .013), respectively. Improving preoperative bilirubin trend had a significant negative predictive value in IOC with a relative risk of .59 ( P = .02). Positive IOC was shown to significantly increase operative length with a relative risk of 2.03 ( P < .001).

Discussion: A rising preoperative bilirubin is a predictor of a positive IOC and patients with normalizing bilirubin levels or a preoperative ERCP are less likely to have choledocholithiasis. These features may be used to select patients that would benefit from an IOC for index admission cholecystectomy.
Evaluating the Implementation Fidelity of a Pilot Pragmatic Randomized Clinical Trial Comparing Daily-Delivered Meals to Mailed Frozen Meals
Authors: Bunker Jennifer N. , Hilgeman Michelle M. , McCreedy Ellen , Gadbois Emily , Thomas Kali S.
Published: April 2024

In pragmatic clinical trials (PCTs), the intervention is carried out by participating sites instead of research staff. In this paper, we evaluate study sites’ implementation adherence during a pilot PCT of home-delivered meals for older adults with dementia. Participants at three home-delivered meal programs were randomized to receive either (1) meals delivered daily or (2) frozen meals mailed every two weeks; participants’ outcomes were tracked for six months. Using the adherence domains from the Framework for Implementation Fidelity, we identified six metrics to assess adherence, with a total possible adherence score ranging from 6 (low adherence) to 18 (high adherence); all three sites scored within the top quartile of adherence. Despite challenges to meal delivery during the COVID-19 pandemic, sites successfully implemented the intervention, justifying a follow-on PCT to test the comparative effectiveness of models of meal delivery on the time to nursing home placement for people living with dementia.
Research on the performance of three-dimensional-braided-glass fiber reinforced in-situ polymerized TPU
Authors: Jiang Lin , Zhang Run , Xue Ping , Jia Mingyin , Cai JianChen
Published: April 2024

In this study, thermoplastic polyurethane (TPU) is prepared by using 4,4′-methylenediphenyl diisocyanate (4,4′-MDI), poly (1,4-butylene adipate) (PBA), and butane-1,4-diol (BDO). PBA as soft segment for TPU. 4,4′- MDI and BDO as hard segment for TPU. The effects of isocyanate index, hard segment content, and soft segment molecular weight on TPU micro-phase separation, molecular weight, and thermal performance are investigated. 3D-Braided-Glass Fiber (GF) reinforced TPU composites are prepared by in-situ polymerized TPU as the matrix resin. Investigation is conducted into how the mechanical properties and microstructure of the composites are affected by the matrix resin TPU’s structural parameters. As the isocyanate index increases, the mechanical properties of the composites first enhance and then weaken, and the interface bonding between TPU and GF gradually deteriorates. Increasing the molecular weight of soft segments has the same trend of change. With the increase of hard segment content, the mechanical properties of the composites are enhanced. The results demonstrate that the mechanical properties of the TPU/GF composites are at their best when the isocyanate index is 1.01, the hard segment content is 43%, and the PBA molecular weight is 2000, with the stretching strength being 289.6 MPa, the impact strength being 141.8 KJ/mm2, the bending strength being 183.2 MPa, and the flexural modulus being 10.7 GPa.
Assessing the Relationship between Corporate Social Responsibility and R&D Effectiveness of Firms
Authors: Ochirova Elena , Miriakov Mikhail , Dranev Yury , Kamunin Nikita
Published: April 2024

Practices of corporate social responsibility often generate synergetic effects and improve financial and overall firm’s performance. However, in the high-tech industries, research and development (R&D) efficiency remains a key element of development strategy, and a shift towards sustainable activities can be considered as a trade-off. This study investigates the empirical link between corporate social responsibility practices and R&D effectiveness in R&D-intensive industries. Specifically, this research assesses the impact of environmental, social, and governance information disclosure, the availability of third-party rating, and long-termism on R&D returns. We employ the Hausman–Taylor estimator to analyze three R&D-intensive industries, namely pharmaceuticals, biotechnology and software, for the period from 2012 to 2019. Empirical results show that, in general, higher values of corporate social responsibility metrics are associated with the weaker R&D returns. The findings of this research might be meaningful for managers in making informed decisions with respect to corporate social responsibility practices.
Michel Serres’s Sensorial Philosophy and the Importance of Skin in Francis Bacon’s Nudes
Authors: Hunt Kevin
Published: April 2024

Prompted by the exhibition Francis Bacon: Man and Beast (January–April 2022), this article takes a cultural studies and historical poetics approach to the significance of skin in Bacon’s nudes. Drawing upon Michel Serres’s philosophy and the work of prominent figures within skin studies, this article argues that Bacon’s paintings intuitively embody the significance of skin as a dynamic site/sight of sensory, lived, experience shaped by socio-historical context. Bacon’s nudes are considered in relation to the dermalogical turn; the topological body; Didier Anzieu’s skin ego and skin as our ‘deepest surface’; and the importance of movement in Bacon’s imagery, which correlates with Serres’s notion that learning occurs through bodily motion. Serres recognises that cultural works – including painting and other creative practices – can convey complex multiplicities of knowledge synthesised into new and distinct forms.
Brain on Fire: How Brain Infection and Neuroinflammation Drive Worldwide Epilepsy Burden
Authors: Barker-Haliski Melissa , DePaula-Silva Ana Beatriz , Pitsch Julika , Sontheimer Harald , Hirsch Lawrence J. , Galanopoulou Aristea S. , Kearney Jennifer A.
Published: April 2024

Roughly 80% of the global burden of epilepsy resides in low- and middle-income countries (LMICs; WHO, 2022). Despite numerous new therapies for the treatment of epilepsy, the number of patients who remain resistant to available medications is unchanged. Additionally, no therapy has yet been clinically proven to prevent or attenuate the development of epilepsy in at-risk individuals. Unfortunately, access to next generation therapies in LMICs is low, the stigma associated with epilepsy remains high, and access to adequate resources is unchanged. Thus, the global epilepsy burden disproportionately falls on LMICs such that strategies to conscientiously integrate global epilepsy risk factors into preclinical research may meaningfully advance 21st century epilepsy therapies. Brain infections are one of the main risk factors for epilepsy in resource-poor settings. Further, both infection- and autoimmune-associated encephalitis contribute to worldwide epilepsy risk and remain relatively understudied. For example, clinical SARS CoV-2 infection can induce rare instances of encephalopathy and acute seizures. Among viruses known to cause acute brain infection, enteroviruses increase risk for encephalitis-induced epilepsy, but are not associated with risk for other neurodevelopmental disorders (eg, autism spectrum or attentional deficit hyperactivity disorders). Naturally occurring models of viral infection-induced epilepsy therefore provide an exquisite opportunity to uncover novel contributors to epileptogenesis. Moreover, the convergent neuroinflammatory pathways that are associated with viral infection-induced encephalitis and autoimmune encephalitis reflect an untapped therapeutic opportunity to meaningfully reduce the global burden of epilepsy. This review summarizes the latest advances in translational research integrating encephalitis-induced seizure and epilepsy models, in tandem with progress in clinical diagnosis of inflammation and virally mediated epilepsy. This improved awareness of the shared biological underpinnings of epileptogenesis following brain infection or autoimmune encephalitis is anticipated to beneficially impact the global burden of epilepsy.
Mine for life: Charting ownership effects in memory from adolescence to old age
Authors: Clarkson Tessa R , Paff Harrison A , Cunningham Sheila J , Ross Josephine , Haslam Catherine , Kritikos Ada
Published: April 2024

This study investigates the self-reference effect (SRE) with an ownership memory task across several age groups, providing the first age exploration of implicit ownership memory biases from adolescence to older adulthood ( N = 159). Using a well-established ownership task, participants were required to sort images of grocery items as belonging to themselves or to a fictitious unnamed Other. After sorting and a brief distractor task, participants completed a surprise one-step source memory test. Overall, there was a robust SRE, with greater source memory accuracy for self-owned items. The SRE attenuated with age, such that the magnitude of difference between self and other memory diminished into older adulthood. Importantly, these findings were not due to a deterioration of memory for self-owned items, but rather an increase in memory performance for other-owned items. Linear mixed effects analyses showed self-biases in reaction times, such that self-owned items were identified more rapidly compared with other owned items. Again, age interacted with this effect showing that the responses of older adults were slowed, especially for other-owned items. Several theoretical implications were drawn from these findings, but we suggest that older adults may not experience ownership-related biases to the same degree as younger adults. Consequently, SREs through the lens of mere ownership may attenuate with age.
The influence of neonatal BCG vaccination on in vitro cytokine responses to Plasmodium falciparum
Authors: Messina NL , Wang M , Forbes EK , Freyne B , Hasang WP , Germano S , Bonnici R , Summons F , Gardiner K , Donath S , Gordon R , Rogerson SJ , Curtis N
Published: April 2024

Background

Bacillus Calmette–Guérin (BCG) vaccination has off-target protective effects against infections unrelated to tuberculosis. Among these, murine and human studies suggest that BCG vaccination may protect against malaria. We investigated whether BCG vaccination influences neonatal in vitro cytokine responses to Plasmodium falciparum. Blood samples were collected from 108 participants in the Melbourne Infant Study BCG for Allergy and Infection Reduction (MIS BAIR) randomised controlled trial (Clinical trials registration NCT01906853, registered July 2013), seven days after randomisation to neonatal BCG (n = 66) or no BCG vaccination (BCG-naïve, n = 42). In vitro cytokine responses were measured following stimulation with P. falciparum-infected erythrocytes (PfIE) or E. coli.

Results

No difference in the measured cytokines were observed between BCG-vaccinated and BCG-naïve neonates following stimulation with PfIE or E. coli. However, age at which blood was sampled was independently associated with altered cytokine responses to PfIE. Being male was also independently associated with increased TNF-a responses to both PfIE and E. coli.

Conclusion

These findings do not support a role for BCG vaccination in influencing in vitro neonatal cytokine responses to P. falciparum. Older neonates are more likely to develop P. falciparum-induced IFN-γ and IFN-γ-inducible chemokine responses implicated in early protection against malaria and malaria pathogenesis.
Establishment and validation of a nomogram for predicting overall survival of upper-tract urothelial carcinoma with bone metastasis: a population-based study
Authors: Hu Jiasheng , Gu Haowen , Zhang Dongxu , Wen Min , Yan Zejun , Song Baiyang , Xie Chengxin
Published: April 2024

Background

Bone metastasis (BM) carries a poor prognosis for patients with upper-tract urothelial carcinoma (UTUC). This study aims to identify survival predictors and develop a prognostic nomogram for overall survival (OS) in UTUC patients with BM.

Methods

The Surveillance, Epidemiology, and End Results database was used to select patients with UTUC between 2010 and 2019. The chi-square test was used to assess the baseline differences between the groups. Kaplan–Meier analysis was employed to assess OS. Univariate and multivariate analyses were conducted to identify prognostic factors for nomogram establishment. An independent cohort was used for external validation of the nomogram. The discrimination and calibration of the nomogram were evaluated using concordance index (C-index), area under receiver operating characteristic curve (AUC), calibration curve, and decision curve analysis (DCA). All statistical analyses were performed using SPSS 23.0 and R software 4.2.2.

Results

The mean OS for UTUC patients with BM was 10 months (95% CI: 8.17 to 11.84), with 6-month OS, 1-year OS, and 3-year OS rates of 41%, 21%, and 3%, respectively. Multi-organ metastases (HR = 2.21, 95% CI: 1.66 to 2.95, P < 0.001), surgery (HR = 0.72, 95% CI: 0.56 to 0.91, P = 0.007), and chemotherapy (HR = 0.37, 95% CI: 0.3 to 0.46, P < 0.001) were identified as independent prognostic factors. The C-index was 0.725 for the training cohort and 0.854 for the validation cohort, and all AUC values were > 0.679. The calibration curve and DCA curve showed the accuracy and practicality of the nomogram.

Conclusions

The OS of UTUC patients with BM was poor. Multi-organ metastases was a risk factor for OS, while surgery and chemotherapy were protective factors. Our nomogram was developed and validated to assist clinicians in evaluating the OS of UTUC patients with BM.
The association between dietary patterns and metabolic syndrome among Iranian adults, a cross-sectional population-based study (findings from Bandare-Kong non-communicable disease cohort study)
Authors: Kheirandish Masoumeh , Dastsouz Farideh , Azarbad Abnoos , Mohsenpour Mohammad Ali , Javdan Gholamali , Razmpour Farkhondeh , Davoodi Seyed Hossein , Ramezani-Jolfaie Nahid , Mohammadi Mohammad
Published: April 2024

Background

Metabolic syndrome is a cluster of metabolic disorders increasing the risk of cardiovascular disease and diabetes. Dietary patterns are supposed to be important and controllable factors in developing metabolic syndrome. The purpose of this study was to investigate the association of dietary patterns with metabolic syndrome and its components.

Subjects/Methods

Cross-sectional data were extracted from the Bandare-Kong cohort study conducted on 4063 people aged 35 to 70. Dietary patterns were extracted using principal component analysis based on thirty-eight pre-defined food groups. Multivariable logistic regression was conducted to investigate the association between metabolic syndrome and its components with quintiles of dietary patterns in crude and adjusted models.

Results

Three major dietary patterns were identified (healthy, western, and traditional) in the final analysis of 2823 eligible individuals. After adjusting for covariates, the odds of metabolic syndrome were significantly decreased by 46% in subjects with the highest adherence to the healthy dietary pattern compared to those with the lowest adherence quintile. Results from fully adjusted models on individual metabolic syndrome components showed an inverse association between higher adherence to the healthy dietary pattern and the odds of increased blood glucose, high waist circumference, and elevated blood pressure. However, in fully adjusted models, no significant association was observed between the western and traditional dietary patterns with odds of metabolic syndrome and its components.

Conclusions

Adherence to a healthy dietary pattern containing high amounts of fruits, vegetables, nuts, low-fat dairy products, and legumes, could be recommended to prevent and control metabolic syndrome.
Access to quality-assured artemisinin-based combination therapy and associated factors among clients of selected private drug outlets in Uganda
Authors: Ocan Moses , Nakalembe Loyce , Otike Caroline , Mordecai Tayebwa , Birungi Joan , Nsobya Sam
Published: April 2024

Background

Malaria treatment in sub-Saharan Africa is faced with challenges including unreliable supply of efficacious agents, substandard medicines coupled with high price of artemisinin-based combinations. This affects access to effective treatment increasing risk of malaria parasite resistance development and adverse drug events. This study investigated access to quality-assured artemisinin-based combination therapy (QAACT) medicines among clients of selected private drug-outlets in Uganda.

Methods

This was a cross sectional study where exit interviews were conducted among clients of private drug outlets in low and high malaria transmission settings in Uganda. This study adapted the World Health Organization/Health Action International (WHO/HAI) standardized criteria. Data was collected using a validated questionnaire. Data entry screen with checks was created in Epi-data ver 4.2 software and data entered in duplicate. Data was transferred to STATA ver 14.0 and cleaned prior to analysis. The analysis was done at 95% level of significance.

Results

A total of 1114 exit interviews were conducted among systematically sampled drug outlet clients. Over half, 54.9% (611/1114) of the participants were males. Majority, 97.2% (1083/1114) purchased an artemisinin-based combination anti-malarial. Most, 55.5% (618/1114) of the participants had a laboratory diagnosis of malaria. Majority, 77.9% (868/1114) of the participants obtained anti-malarial agents without a prescription. Less than a third, 27.7% (309/1114) of the participants obtained a QAACT. Of the participants who obtained QAACT, more than half 56.9% (173/309) reported finding the medicine expensive. The predictors of accessing a QAACT anti-malarial among drug outlet clients include type of drug outlet visited (aPR = 0.74; 95%CI 0.6, 0.91), not obtaining full dose (3-day treatment) of ACT (aPR = 0.49; 95%CI 0.33, 0.73), not finding the ACT expensive (aPR = 1.24; 95%CI 1.03, 1.49), post-primary education (aPR = 1.29; 95%CI 1.07,1.56), business occupation (aPR = 1.24; 95%CI 1.02,1.50) and not having a prescription (aPR = 0.76; 95%CI 0.63, 0.92).

Conclusion

Less than a third of the private drug outlet clients obtained a QAACT for management of malaria symptoms. Individuals who did not find artemisinin-based combinations to be expensive were more likely to obtain a QAACT anti-malarial. The Ministry of Health needs to conduct regular surveillance to monitor accessibility of QAACT anti-malarial agents under the current private sector copayment mechanism.
Intensity Score of Vessel Wall Contrast Enhancement in MRI Allows Prediction of Disease Progression in Moyamoya Angiopathy
Authors: Shih-Yüng Wang Sophie , Hauser Till-Karsten , Haas Patrick , Tellermann Jonas , Hurth Helene , Ernemann Ulrike , Tatagiba Marcos , Bender Benjamin , Khan Nadia , Roder Constantin
Published: April 2024

BACKGROUND AND OBJECTIVES:

The underlying pathophysiological cause of moyamoya angiopathy (MMA) is still unclear. High-resolution vessel wall imaging has become a useful tool. The aim was to study vessel wall contrast-enhancement (VW-CE) as an imaging marker to predict disease progression in MMA.

METHODS:

Patients with MMA, who had undergone serial contrast-enhanced high-resolution MRI with concomitant and follow-up digital subtraction angiography, were analyzed retrospectively. VW-CE was semiquantified by measurement of the signal intensity of the vessel wall in in contrast-enhanced high-resolution MRI. A comparative quotient with the contrast-intensity of the pituitary stalk was calculated and graded accordingly from grade 1 to 5. VW-CE status was correlated with disease status, stroke, cerebrovascular reactivity in CO2-triggered blood-oxygen level-dependent MRI, angiographic disease progression, revascularization surgery, and follow-up imaging.

RESULTS:

Forty eight patients met the inclusion criteria. N = 56 MRI and digital subtraction angiography time-intervals were evaluated for 12 vessel sections per hemisphere each (N = 1344). N = 38 (79%) patients showed VW-CE and N = 10 (21%) did not. VW-CE was only observed in the terminal internal carotid artery and the proximal circle of Willis (N = 96/1344). Notably, patients with VW-CE significantly more often presented with acute infarction in the concomitant MRI. The incidence of angiographically proven disease progression was significantly associated with the incidence of VW-CE, and time to disease progression was earlier in higher grades of VW-CE compared with lower grades.

CONCLUSION:

VW-CE is a semiquantifiable marker for disease activity in patients with MMA and associated with disease progression and increased risk of stroke. VW-CE analysis can be routinely performed in patients with MMA to estimate the risk for disease progression and stroke.
Transarterial Embolization of Intracranial Dural Arteriovenous Fistulas Cognard Type V With Direct Drainage Into the Perimedullary Veins: Case Report and Literature Review
Authors: Mendoza-Ayús Santiago David , El Naamani Kareem , Atallah Elias , Sizdahkhani Saman , Kaul Anand , Mouchtouris Nikolaos , Tjoumakaris Stavropoula , Gooch Michael R. , Rosenwasser Robert H. , Jabbour Pascal
Published: April 2024

BACKGROUND AND IMPORTANCE:

Cognard type V fistula (CVF) is a rare type of dural arteriovenous fistula characterized by spinal perimedullary venous drainage. Owing to the lack of pathognomonic findings, misdiagnosis is common. Patients often undergo multiple spinal angiograms negative for spinal vascular malformations. Digital subtraction angiography is the gold standard diagnostic tool. The preferred treatment option is endovascular management with embolization through a transarterial, transvenous, or combined approach. Other options include open surgery, stereotactic radiosurgery, or a combination of both.

CLINICAL PRESENTATION:

The patient from case # 1 presented with progressive weakness and hypoesthesia in the bilateral lower extremities, with urinary and bowel incontinence. The DSA identified a CVF fed by the meningohypophyseal trunk and a draining perimedullary vein. Embolization with 0.1 ccs of Onyx-18 was performed with complete fistula occlusion. The patient from case # 2 developed bilateral lower extremity weakness, diffuse numbness, and urinary incontinence. The DSA showed a CVF fed by tributaries from the ascending pharyngeal artery and posterior meningeal artery branches of the V3 segment, draining into a perimedullary vein. Embolization with 0.3 cc of Onyx-18 was performed with 100% occlusion of the fistula. A 1-year follow-up angiogram confirmed complete fistula occlusion. Both patients consented to the procedure.

CONCLUSION:

Even if a patient only presents symptoms of myelopathy, CVF should be considered. Herein, we present 2 cases of CVF with direct drainage into the perimedullary veins which presented exclusively with myelopathy syndrome and describe treatment with trasarterial embolization with Onyx.
Labor and Capital As Factors in Generating Profit in Modern Russia
Authors: Basovskiy Leonid
Published: April 2024

This work is devoted to an attempt to quantitatively assess the influence of traditional and human capital, embodied in labor, on the profit of enterprises in the economy of modern Russia. To assess the impact of human capital on profit, data on the monthly wage fund in the regions of the country was used, which was considered as an indicator of the cost of human capital. Based on Rosstat data on the profits of regional enterprises, data on the average monthly wage of employees of organizations, the number of employed workers in the regions, data on the value of fixed assets of enterprises for 2010, 2015, 2019, 2020 and 2021, linear regression models were obtained. The models showed the dependence of the profits of regional enterprises on the size of the average monthly wage fund in the regions and on the value of fixed assets. The characteristics of the resulting models indicate that the wage fund and the cost of fixed assets have a significant and equal impact on the profits of enterprises. The equivalence of the influence of capital and human capital on profit assumes that the equilibrium is an equal distribution of income between labor and capital. income distribution. Currently, in the economy, the distribution of income is not in equilibrium, since capital income predominates.
Failed bioprosthetic tricuspid valve replacement treated with transcatheter valve for valve repair
Authors: Talebi-Talghian Tara , Cevik Cihan , Walinsky Peter
Published: April 2024

Tricuspid bioprosthetic valve failure may lead to right-sided heart failure and is traditionally managed with surgical valve replacement. However, the substantial mortality risk associated with reoperation for failed tricuspid bioprosthesis prompts the need for less invasive alternatives. Transcatheter valve-in-valve (TViV) implantation presents a promising minimally invasive option for patients with failing bioprosthetic valves.  This case involves a 32-year-old man with a history of recurrent failed bioprosthetic tricuspid valves who underwent successful percutaneous TViV implantation using a 29 mm Edwards Sapien S3 valve, resulting in marked clinical and hemodynamic improvement. This case contributes essential insights to the limited literature on TViV in the tricuspid position, particularly in patients with complex surgical histories. The high procedural success rate and substantial improvement in valve function underscore the potential of TViV as an effective alternative to surgical replacement for failed tricuspid bioprosthetic valves.
 
Keywords: Transcatheter tricuspid valve replacement; tricuspid valve-in-valve; bioprosthetic tricuspid valve; tricuspid valve stenosis
Production Chain Organization in the Digital Age: Information Technology Use and Vertical Integration in U.S. Manufacturing
Authors: Forman Chris , McElheran Kristina
Published: April 2024

Advances in information technology (IT) may affect the organizational design of production. Exploiting the rapid diffusion of the internet in the United States, we assess the sensitivity of production chain organization to this innovation in IT access and use. Extending theories of the firm that recognize the importance of downstream transfers (selling as opposed to sourcing) and plural governance in organizational design, we predict IT-driven shifts in downstream vertical integration. In a detailed panel of Census Bureau data for over 5,600 manufacturing plants, we observe the extent of a production unit’s downstream transactions within the firm alongside concurrent sales to external customers—a mix we refer to as plural selling. Our main finding is that the use of the internet for external coordination precipitated a significant decline in downstream vertical integration across the manufacturing sector. Instrumental variables estimation points to a causal relationship but also heterogeneous treatment effects. Key drivers of plural organization, such as complementarities and constraints across differently governed transactions, help explain such heterogeneity, as does concurrent use of internal production management IT. Our study is the first study to leverage a plural governance framework and large-scale microdata to understand how U.S. production chain organization shifted in response to this rapid and far-reaching technological change.

This paper was accepted by David Simchi-Levi, information systems.

Funding: This research was performed at the Atlanta, Boston, and Cornell (supported by the Cornell Center for the Social Sciences) Federal Statistical Research Data Centers [Project 1069 (CBDRB-FY22-279)]. Support for the Research Data Centers network from the National Science Foundation [Grant ITR-0427889] is gratefully acknowledged, as is support from the Social Sciences and Humanities Research Council of Canada.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2019.01586 .
Politically Affiliated Analysts
Authors: Kong Dongmin , Lin Chen , Liu Shasha , Xuan Yuhai
Published: April 2024

Government ownership of financial intermediaries is pervasive around the world. In this study, we examine the impact of common government ownership between the brokerage and listed firms on the information production role of brokerage firms. We show that affiliated analysts tend to issue more optimistic recommendations for stocks of firms controlled by the same government entity that controls their brokerage firms. This optimistic bias is particularly pronounced during periods of economic shocks. Our study demonstrates this by utilizing additional tariff impositions and tariff exemptions during the U.S.–China trade war as exogenous negative and positive shocks, respectively. Additionally, our study indicates that stocks recommended by politically affiliated analysts tend to underperform those recommended by independent analysts, implying that the optimism stems from conflicts of interest rather than superior information. Furthermore, our research highlights that sophisticated investors perceive the potential bias and incorporate it into their trading. Consistent with an exchange of favors story, politically affiliated brokerage firms receive a larger allocation during the issuance of local government debt, whereas governments subscribe for more shares during seasoned equity offerings by these affiliated brokerage firms.

This paper was accepted by Kay Giesecke, finance.

Funding: The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China [Grants 71972088, 72132002, and 71991473], the National Social Science Foundation of China [Grants 21ZDA010 and 22VRC145], and the Innovation and Talent Base for Digital Technology and Finance [Grant B21038].

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.00579 .
Online Advertising as Passive Search
Authors: Ursu Raluca Mihaela , Simonov Andrey , An Eunkyung
Published: April 2024

Standard search models assume that consumers actively decide on the order, identity, and number of products they search. We document that online, a large fraction of searches happen in a more passive manner, with consumers merely reacting to online advertisements that do not allow them to choose the timing or the identity of products to which they will be exposed. Using a clickstream panel data set capturing full URL addresses of websites that consumers visit, we show how to detect whether a click is ad initiated. We then report that in the apparel category, ad-initiated clicks account for more than half of all website arrivals, are more concentrated early on in the consumer search process, and lead to less in-depth searches and fewer transactions, consistent with the passive nature of these searches. To account for these systematic differences between active and passive searches, we propose and estimate a simple model that accommodates both types of searches. Our results show that incorrectly treating all searches as active inflates the estimated value of brands that advertise frequently. Our model can more accurately recover data patterns, especially for advertising brands. We finish with model extensions and a discussion of the managerial implications.

This paper was accepted by Dmitry Kuksov, marketing.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.02154 .
Prediction of Retinol in Fortified Maize Flour using Fourier Transform - Near Infrared Spectroscopy
Authors: Chepkoech Brenda , N. Wafula Elizabeth , Sila Daniel N. , N. Orina Irene
Published: April 2024

Food fortification is one strategy for addressing micronutrient deficiencies among the population groups at risk. Non-compliance with fortification standards hinders the success of fortification programs. This is due to a lack of techniques to rapidly check the amounts of the added fortificants. Fourier transform - near-infrared (FT-NIR) spectroscopy is a fast and reliable technique that would be used to ensure adherence to requirements. This study aimed to investigate the potential of using FT-NIR spectroscopy to predict the amount of retinol in fortified maize flour. 150 fortified maize flour samples were used in this study. Partial least squares regression (PLS-R) was used to build calibration models based on the retinol reference values obtained by high-performance liquid chromatography (HPLC), and fortified maize flour NIR spectra acquired from the FT-NIR spectrophotometer. Two calibration models were developed to predict retinol above and below 1.0 mg/kg. The performance metrics of model one developed to predict retinol < 1.0 mg/kg were: R2c = 0.81, RMSEE = 0.08, RPD = 2.29 and R2v = 0.82, RMSEP = 0.09, RPD = 2.07 for the calibration and validation, respectively. The second model developed to predict retinol ≥ 1.0 mg/kg had the following performance metrics: R2c = 0.93, RMSEE = 0.16, RPD = 3.58 and R2v = 0.81, RMSEP = 0.22, RPD = 2.43 for the calibration and validation, respectively. Overall, the findings demonstrated that FT-NIR spectroscopy can be utilised to reliably predict retinol levels in fortified maize flour samples. FT-NIR spectroscopy, by replacing time-consuming and laborious wet chemistry laboratory procedures, has the potential to be used for rapid regulatory monitoring of fortification compliance for a large number of samples.