bluuebunny/crossref_metadata_2025 huggingface dataset:
Allocation of Carbon from an Arbuscular Mycorrhizal Fungus, Gigaspora margarita, to Its Gram-Negative and Positive Endobacteria Revealed by High-Resolution Secondary Ion Mass Spectrometry
Authors: Kuga Yukari , Wu Ting-Di , Sakamoto Naoya , Katsuyama Chie , Yurimoto Hisayoshi
Published: December 2021

Arbuscular mycorrhizal fungi are obligate symbionts of land plants; furthermore, some of the species harbor endobacteria. Although the molecular approach increased our knowledge of the diversity and origin of the endosymbiosis and its metabolic possibilities, experiments to address the functions of the fungal host have been limited. In this study, a C flow of the fungus to the bacteria was investigated. Onion seedlings colonized with Gigaspora margarita, possessing Candidatus Glomeribacter gigasporarum (CaGg, Gram-negative, resides in vacuole) and Candidatus Moeniiplasma glomeromycotorum (CaMg, Gram-positive, resides in the cytoplasm,) were labelled with 13CO2. The 13C localization within the mycorrhiza was analyzed using high-resolution secondary ion mass spectrometry (SIMS). Correlative TEM-SIMS analysis of the fungal cells revealed that the 13C/12C ratio of CaGg was the lowest among CaMg and mitochondria and was the highest in the cytoplasm. By contrast, the plant cells, mitochondria, plastids, and fungal cytoplasm, which are contributors to the host, showed significantly higher 13C enrichment than the host cytoplasm. The C allocation patterns implied that CaMg has a greater impact than CaGg on G. margarita, but both seemed to be less burdensome to the host fungus in terms of C cost.
Metabolite Fingerprinting Using 1H-NMR Spectroscopy and Chemometrics for Classification of Three Curcuma Species from Different Origins
Authors: Nurani Laela Hayu , Rohman Abdul , Windarsih Anjar , Guntarti Any , Riswanto Florentinus Dika Octa , Lukitaningsih Endang , Fadzillah Nurrulhidayah Ahmad , Rafi Mohamad
Published: December 2021

Curcuma longa, Curcuma xanthorrhiza, and Curcuma manga have been widely used for herbal or traditional medicine purposes. It was reported that turmeric plants provided several biological activities such as antioxidant, anti-inflammatory, hepatoprotector, cardioprotector, and anticancer activities. Authentication of the Curcuma species is important to ensure its authenticity and to avoid adulteration practices. Plants from different origins will have different metabolite compositions because metabolites are affected by soil nutrition, climate, temperature, and humidity. 1H-NMR spectroscopy, principal component analysis (PCA), and orthogonal projections to latent structures-discriminant analysis (OPLS-DA) were used for authentication of C. longa, C. xanthorrhiza, and C. manga from seven different origins in Indonesia. From the 1H-NMR analysis it was obtained that 14 metabolites were responsible for generating classification model such as curcumin, demethoxycurcumin, alanine, methionine, threonine, lysine, alpha-glucose, beta-glucose, sucrose, alpha-fructose, beta-fructose, fumaric acid, tyrosine, and formate. Both PCA and OPLS-DA model demonstrated goodness of fit (R2 value more than 0.8) and good predictivity (Q2 value more than 0.45). All OPLS-DA models were validated by assessing the permutation test results with high value of original R2 and Q2. It can be concluded that metabolite fingerprinting using 1H-NMR spectroscopy and chemometrics provide a powerful tool for authentication of herbal and medicinal plants.
Relationship between the Chemical Composition and the Biological Functions of Coffee
Authors: Saud Shah , Salamatullah Ahmad Mohammad
Published: December 2021

Coffee is a Rubiaceae coffee plant ranked as the first of the three most important beverages in the world, with effects including lowering blood sugar, protecting the liver, and protecting the nerves. Coffee contains many chemical components, including alkaloids, phenolic acids, flavonoids, terpenoids, and so on. Chemical components in coffee are the basis of its biological function and taste. The chemical components are the basis of biological activities and form the characteristic aroma of coffee. The main chemical components and biological activities of coffee have been extensively studied, which would provide a relevant basis and theoretical support for the further development of the coffee industry.
Anti-Pathogenic Properties of the Combination of a T3SS Inhibitory Halogenated Pyrrolidone with C-30 Furanone
Authors: Aburto-Rodríguez Nelly Araceli , Muñoz-Cázares Naybi , Castro-Torres Víctor Alberto , González-Pedrajo Bertha , Díaz-Guerrero Miguel , García-Contreras Rodolfo , Quezada Héctor , Castillo-Juárez Israel , Martínez-Vázquez Mariano
Published: December 2021

Antimicrobial resistance is one of the current public health challenges to be solved. The World Health Organization (WHO) has urgently called for the development of strategies to expand the increasingly limited antimicrobial arsenal. The development of anti-virulence therapies is a viable option to counteract bacterial infections with the possibility of reducing the generation of resistance. Here we report on the chemical structures of pyrrolidones DEXT 1–4 (previously identified as furan derivatives) and their anti-virulence activity on Pseudomonas aeruginosa strains. DEXT 1–4 were shown to inhibit biofilm formation, swarming motility, and secretion of ExoU and ExoT effector proteins. Also, the anti-pathogenic property of DEXT-3 alone or in combination with furanone C-30 (quorum sensing inhibitor) or MBX-1641 (type III secretion system inhibitor) was analyzed in a model of necrosis induced by P. aeruginosa PA14. All treatments reduced necrosis; however, only the combination of C-30 50 µM with DEXT-3 100 µM showed significant inhibition of bacterial growth in the inoculation area and systemic dispersion. In conclusion, pyrrolidones DEXT 1–4 are chemical structures capable of reducing the pathogenicity of P. aeruginosa and with the potential for the development of anti-virulence combination therapies.
Naturally Occurring Chromone Glycosides: Sources, Bioactivities, and Spectroscopic Features
Authors: Amen Yhiya , Elsbaey Marwa , Othman Ahmed , Sallam Mahmoud , Shimizu Kuniyoshi
Published: December 2021

Chromone glycosides comprise an important group of secondary metabolites. They are widely distributed in plants and, to a lesser extent, in fungi and bacteria. Significant biological activities, including antiviral, anti-inflammatory, antitumor, antimicrobial, etc., have been discovered for chromone glycosides, suggesting their potential as drug leads. This review compiles 192 naturally occurring chromone glycosides along with their sources, classification, biological activities, and spectroscopic features. Detailed biosynthetic pathways and chemotaxonomic studies are also described. Extensive spectroscopic features for this class of compounds have been thoroughly discussed, and detailed 13C-NMR data of compounds 1–192, have been added, except for those that have no reported 13C-NMR data.
Two-Channel VO2 Memory Meta-Device for Terahertz Waves
Authors: Lu Xueguang , Dong Bowen , Zhu Hongfu , Shi Qiwu , Tang Lu , Su Yidan , Zhang Cheng , Huang Wanxia , Cheng Qiang
Published: December 2021

Vanadium oxide (VO2), as one of the classical strongly correlated oxides with a reversible and sharp insulator-metal transition (IMT), enables many applications in dynamic terahertz (THz) wave control. Recently, due to the inherent phase transition hysteresis feature, VO2 has shown favorable application prospects in memory-related devices once combined with metamaterials or metasurfaces. However, to date, VO2-based memory meta-devices are usually in a single-channel read/write mode, which limits their storage capacity and speed. In this paper, we propose a reconfigurable meta-memory based on VO2, which favors a two-channel read/write mode. Our design consists of a pair of large and small split-ring resonators, and the corresponding VO2 patterns are embedded in the gap locations. By controlling the external power supply, the two operation bands can be controlled independently to achieve at least four amplitude states, including “00”, “01”, “10”, and “11”, which results in a two-channel storage function. In addition, our research may provide prospective applications in fields such as THz switching, photon storage, and THz communication systems in the future.
On-Demand Drug Delivery Systems Using Nanofibers
Authors: Singh Baljinder , Kim Kibeom , Park Myoung-Hwan
Published: December 2021

On-demand drug-delivery systems using nanofibers are extensively applicable for customized drug release based on target location and timing to achieve the desired therapeutic effects. A nanofiber formulation is typically created for a certain medication and changing the drug may have a significant impact on the release kinetics from the same delivery system. Nanofibers have several distinguishing features and properties, including the ease with which they may be manufactured, the variety of materials appropriate for processing into fibers, a large surface area, and a complex pore structure. Nanofibers with effective drug-loading capabilities, controllable release, and high stability have gained the interest of researchers owing to their potential applications in on-demand drug delivery systems. Based on their composition and drug-release characteristics, we review the numerous types of nanofibers from the most recent accessible studies. Nanofibers are classified based on their mechanism of drug release, as well as their structure and content. To achieve controlled drug release, a suitable polymer, large surface-to-volume ratio, and high porosity of the nanofiber mesh are necessary. The properties of nanofibers for modified drug release are categorized here as protracted, stimulus-activated, and biphasic. Swellable or degradable polymers are commonly utilized to alter drug release. In addition to the polymer used, the process and ambient conditions can have considerable impacts on the release characteristics of the nanofibers. The formulation of nanofibers is highly complicated and depends on many variables; nevertheless, numerous options are available to accomplish the desired nanofiber drug-release characteristics.
The Effect of TiO2 Nanoparticles on the Composition and Ultrastructure of Wheat
Authors: Soran Maria-Loredana , Lung Ildiko , Opriș Ocsana , Culicov Otilia , Ciorîță Alexandra , Stegarescu Adina , Zinicovscaia Inga , Yushin Nikita , Vergel Konstantin , Kacso Irina , Borodi Gheorghe
Published: December 2021

The present work aims to follow the influence of TiO2 nanoparticles (TiO2 NPs) on bioactive compounds, the elemental content of wheat, and on wheat leaves’ ultrastructure. Synthesized nanoparticles were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and transmission electron microscopy (TEM). The concentration of phenolic compounds, assimilation pigments, antioxidant capacity, elemental content, as well as the ultrastructural changes that may occur in the wheat plants grown in the presence or absence of TiO2 NPs were evaluated. In plants grown in the presence of TiO2 NPs, the amount of assimilating pigments and total polyphenols decreased compared to the control sample, while the antioxidant activity of plants grown in amended soil was higher than those grown in control soil. Following ultrastructural analysis, no significant changes were observed in the leaves of TiO2-treated plants. Application of TiO2 NPs to soil caused a significant reaction of the plant to stress conditions. This was revealed by the increase of antioxidant capacity and the decrease of chlorophyll, total polyphenols, and carotenoids. Besides, the application of TiO2 NPs led to significant positive (K, Zn, Br, and Mo) and negative (Na, Mn, Fe, As, Sr, Sb, and Ba) variation of content.
Influence of Ag Photodeposition Conditions over SERS Intensity of Ag/ZnO Microspheres for Nanomolar Detection of Methylene Blue
Authors: Zamora-Peredo Luis , García-Ramirez Josué Ismael , García-Velasco Amado Carlos , Hernández-Torres Julián , García-González Leandro , Bizarro Monserrat , Báez-Rodríguez Adriana
Published: December 2021

Surface enhanced Raman spectroscopy (SERS) is considered a versatile and multifunctional technique with the ability to detect molecules of different species at very low molar concentration. In this work, hierarchical ZnO microspheres (ZnO MSs) and Ag/ZnO MSs were fabricated and decorated by hydrothermal and photodeposition methods, respectively. For Ag deposition, precursor molar concentration (1.9 and 9.8 mM) and UV irradiation time (5, 15, and 30 min) were evaluated by SEM, TEM, X-ray diffraction and Raman spectroscopy. X-ray diffraction showed a peak at 37.9° corresponding to the (111) plane of Ag, whose intensity increases as precursor concentration and UV irradiation time increases. SEM images confirmed the formation of ZnO MSs (from 2.5 to 4.5 µm) building by radially aligned two-dimensional ZnO nanosheets with thicknesses below 30 nm. The Raman spectra of Ag/ZnO MSs exhibited a vibration mode at 486 cm−1 which can be directly associated to Ag deposition on ZnO MSs surface. The performance of SERS substrate was evaluated using rhodamine 6G. The SERS substrate grown at 9.8 mM during 30 min showed the best SERS activity and the ability to detect methylene blue at 10−9 M.
Silicone Elastomer Composites Fabricated with MgO and MgO-Multi-Wall Carbon Nanotubes with Improved Thermal Conductivity
Authors: Kagenda Christopher , Lee Jae , Memon Fida , Ahmed Faheem , Samantasinghar Anupama , Akhtar Muhammad , Khalique Abdul , Choi Kyung
Published: December 2021

The effect of multiwall carbon nanotubes (MWCNTs) and magnesium oxide (MgO) on the thermal conductivity of MWCNTs and MgO-reinforced silicone rubber was studied. The increment of thermal conductivity was found to be linear with respect to increased loading of MgO. In order to improve the thermal transportation of phonons 0.3 wt % and 0.5 wt % of MWCNTs were added as filler to MgO-reinforced silicone rubber. The MWCNTs were functionalized by hydrogen peroxide (H2O2) to activate organic groups onto the surface of MWCNTs. These functional groups improved the compatibility and adhesion and act as bridging agents between MWCNTs and silicone elastomer, resulting in the formation of active conductive pathways between MgO and MWCNTs in the silicone elastomer. The surface functionalization was confirmed with XRD and FTIR spectroscopy. Raman spectroscopy confirms the pristine structure of MWCNTs after oxidation with H2O2. The thermal conductivity is improved to 1 W/m·K with the addition of 20 vol% with 0.5 wt % of MWCNTs, which is an ~8-fold increment in comparison to neat elastomer. Improved thermal conductive properties of MgO-MWCNTs elastomer composite will be a potential replacement for conventional thermal interface materials.
The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder
Authors: Chernikova Michelle A. , Flores Genesis D. , Kilroy Emily , Labus Jennifer S. , Mayer Emeran A. , Aziz-Zadeh Lisa
Published: December 2021

Gastrointestinal dysfunction is one of the most prevalent physiological symptoms of autism spectrum disorder (ASD). A growing body of largely preclinical research suggests that dysbiotic gut microbiota may modulate brain function and social behavior, yet little is known about the mechanisms that underlie these relationships and how they may influence the pathogenesis or severity of ASD. While various genetic and environmental risk factors have been implicated in ASD, this review aims to provide an overview of studies elucidating the mechanisms by which gut microbiota, associated metabolites, and the brain interact to influence behavior and ASD development, in at least a subgroup of individuals with gastrointestinal problems. Specifically, we review the brain-gut-microbiome system and discuss findings from current animal and human studies as they relate to social-behavioral and neurological impairments in ASD, microbiota-targeted therapies (i.e., probiotics, fecal microbiota transplantation) in ASD, and how microbiota may influence the brain at molecular, structural, and functional levels, with a particular interest in social and emotion-related brain networks. A deeper understanding of microbiome-brain-behavior interactions has the potential to inform new therapies aimed at modulating this system and alleviating both behavioral and physiological symptomatology in individuals with ASD.
Stakeholders’ Perspectives on the Current Status of Partnerships between the Food Banking and Healthcare Systems to Address Food Insecurity in the U.S.
Authors: Abebe Gurganus Eminet , Marfo Nana Yaa A. , Schwartz Marlene B. , Cooksey Stowers Kristen
Published: December 2021

One in eight people in the U.S. experience food insecurity (FI). To date, the food banking sector has been at the forefront of efforts to address FI, but the healthcare sector is becoming increasingly involved in such efforts. The extent of collaboration between the two sectors remains unclear. We explored food banking stakeholders’ views on the current state of partnerships between the two sectors. We used purposive sampling to recruit ten key informants for semi-structured interviews. We also conducted a national online survey to gather data from food bank directors (n = 137). Thematic analysis generated two major themes: (1) Healthcare and food banking stakeholders are coordinating to achieve collective impact, and (2) Food banking-healthcare partnerships are leveraging various resources and vested interests within the medical community. We found evidence of ongoing partnerships between the two sectors and opportunities to strengthen these partnerships through the support of backbone organizations.
Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression
Authors: Matos Andreia , Carvalho Marcos , Bicho Manuel , Ribeiro Ricardo
Published: December 2021

Arginine availability and activation of arginine-related pathways at cancer sites have profound effects on the tumor microenvironment, far beyond their well-known role in the hepatic urea cycle. Arginine metabolism impacts not only malignant cells but also the surrounding immune cells behavior, modulating growth, survival, and immunosurveillance mechanisms, either through an arginase-mediated effect on polyamines and proline synthesis, or by the arginine/nitric oxide pathway in tumor cells, antitumor T-cells, myeloid-derived suppressor cells, and macrophages. This review presents evidence concerning the impact of arginine metabolism and arginase activity in the prostate cancer microenvironment, highlighting the recent advances in immunotherapy, which might be relevant for prostate cancer. Even though further research is required, arginine deprivation may represent a novel antimetabolite strategy for the treatment of arginine-dependent prostate cancer.
Dose Finding and Food Effect Studies of a Novel Abiraterone Acetate Formulation for Oral Suspension in Comparison to a Reference Formulation in Healthy Male Subjects
Authors: Jordán Tamás , Basa-Dénes Orsolya , Angi Réka , Orosz János , Ötvös Zsolt , Ujhelyi Andrea , Filipcsei Genovéva , Molnár László , Solymosi Tamás , Glavinas Hristos , Capone Dominic , Whitfield Nicola , McDermott John , McKenzie Litza , Shurety Lauren , Duus Elizabeth Manning
Published: December 2021

Currently approved formulations of the androgen synthesis inhibitor abiraterone acetate (AA) consist of multiple tablets administered daily in a fasted state. Removing the food effect and switching to a suspension formulation is expected to improve the pharmacokinetic profile and facilitate drug administration for patients with late-stage prostate cancer. Two four-sequence, four-period randomized crossover investigations were undertaken to establish the pharmacokinetic profiles of single doses of commercially available Zytiga®, as the reference AA (R-AA), and a novel tablet for oral suspension (TOS). Four single doses of TOS (from 62.5 to 250 mg) were compared in study C01, and two single doses each of TOS (250 mg) and R-AA (1000 mg) were compared under fasted and fed (modified fasted for R-AA) conditions in C02. Plasma concentrations of abiraterone over time were measured, and pharmacokinetic parameters were calculated. Each doubling of the dose of TOS was associated with a greater than 3-fold increase in exposure. A single dose of TOS (250 mg) exhibited similar exposure over 24 h, whether given fasted (625 ng × h/mL) or fed (485 ng × h/mL). A single dose of TOS (250 mg) was associated with higher (fasted, p = 0.028) or equivalent exposure (fed) compared to 1000 mg R-AA fasted (532 ng × h/mL). Substantially higher exposures were seen with 1000 mg R-AA under modified fasted conditions compared to TOS, irrespective of prandial status (p < 0.001). TOS was generally safe and well tolerated in the study. A 250 mg dose of a novel AA formulation for oral suspension demonstrated bioequivalence to 1000 mg R-AA under fasted conditions. This novel TOS formulation also addresses some of the limitations of current AA treatment, including low bioavailability, high variability in systemic exposure and a large food effect. It may offer an alternative for patients with dysphagia or discomfort with swallowing large pills.
Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats
Authors: Karbownik Agnieszka , Szkutnik-Fiedler Danuta , Grabowski Tomasz , Wolc Anna , Stanisławiak-Rudowicz Joanna , Jaźwiec Radosław , Grześkowiak Edmund , Szałek Edyta
Published: December 2021

A combination of the tyrosine kinase inhibitor—sorafenib—and the opioid analgesic—morphine—can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an inhibitor of P-gp, their co-administration may affect their pharmacokinetics, and thus the safety and efficacy of cancer therapy. Therefore, the aim of this study was to evaluate the potential pharmacokinetic drug–drug interactions between sorafenib and morphine using an animal model. The rats were divided into three groups that Received: sorafenib and morphine (ISOR+MF), sorafenib (IISOR), and morphine (IIIMF). Morphine caused a significant increase in maximum plasma concentrations (Cmax) and the area under the plasma concentration–time curves (AUC0–t, and AUC0–∞) of sorafenib by 108.3 (p = 0.003), 55.9 (p = 0.0115), and 62.7% (p = 0.0115), respectively. Also, the Cmax and AUC0–t of its active metabolite—sorafenib N-oxide—was significantly increased in the presence of morphine (p = 0.0022 and p = 0.0268, respectively). Sorafenib, in turn, caused a significant increase in the Cmax of morphine (by 0.5-fold, p = 0.0018). Moreover, in the presence of sorafenib the Cmax, AUC0–t, and AUC0–∞ of the morphine metabolite M3G increased by 112.62 (p < 0.0001), 46.82 (p = 0.0124), and 46.78% (p = 0.0121), respectively. Observed changes in sorafenib and morphine may be of clinical significance. The increased exposure to both drugs may improve the response to therapy in cancer patients, but on the other hand, increase the risk of adverse effects.
New Intracellular Peptide Derived from Hemoglobin Alpha Chain Induces Glucose Uptake and Reduces Blood Glycemia
Authors: Silva Renée N. O. , Llanos Ricardo P. , Eichler Rosangela A. S. , Oliveira Thiago B. , Gozzo Fábio C. , Festuccia William T. , Ferro Emer S.
Published: December 2021

Intracellular peptides were shown to derive from proteasomal degradation of proteins from mammalian and yeast cells, being suggested to play distinctive roles both inside and outside these cells. Here, the role of intracellular peptides previously identified from skeletal muscle and adipose tissues of C57BL6/N wild type (WT) and neurolysin knockout mice were investigated. In differentiated C2C12 mouse skeletal muscle cells, some of these intracellular peptides like insulin activated the expression of several genes related to muscle contraction and gluconeogenesis. One of these peptides, LASVSTVLTSKYR (Ric4; 600 µg/kg), administrated either intraperitoneally or orally in WT mice, decreased glycemia. Neither insulin (10 nM) nor Ric4 (100 µM) induced glucose uptake in adipose tissue explants obtained from conditional knockout mice depleted of insulin receptor. Ric4 (100 µM) similarly to insulin (100 nM) induced Glut4 translocation to the plasma membrane of C2C12 differentiated cells, and increased GLUT4 mRNA levels in epididymal adipose tissue of WT mice. Ric4 (100 µM) increased both Erk and Akt phosphorylation in C2C12, as well as in epididymal adipose tissue from WT mice; Erk, but not Akt phosphorylation was activated by Ric4 in tibial skeletal muscle from WT mice. Ric4 is rapidly degraded in vitro by WT liver and kidney crude extracts, such a response that is largely reduced by structural modifications such as N-terminal acetylation, C-terminal amidation, and substitution of Leu8 for DLeu8 (Ac-LASVSTV[DLeu]TSKYR-NH2; Ric4-16). Ric4-16, among several Ric4 derivatives, efficiently induced glucose uptake in differentiated C2C12 cells. Among six Ric4-derivatives evaluated in vivo, Ac-LASVSTVLTSKYR-NH2 (Ric4-2; 600 µg/kg) and Ac-LASVSTV[DLeu]TSKYR (Ric4-15; 600 µg/kg) administrated orally efficiently reduced glycemia in a glucose tolerance test in WT mice. The potential clinical application of Ric4 and Ric4-derivatives deserves further attention.
Mechanical Properties and Thermal Conductivity of Thermal Insulation Board Containing Recycled Thermosetting Polyurethane and Thermoplastic
Authors: He Ping , Ruan Haoda , Wang Congyang , Lu Hao
Published: December 2021

This study used a mechanochemical method to analyze the recycling mechanism of polyurethane foam and optimize the recycling process. The use of mechanochemical methods to regenerate the polyurethane foam powder breaks the C–O bond of the polyurethane foam and greatly enhances the activity of the powder. Based on orthogonal test design, the mesh, proportion, temperature, and time were selected to produce nine recycled boards by heat pressing. Then, the influence of four factors on the thermal conductivity and tensile strength of the recycled board was analyzed. The results show that 120 mesh polyurethane foam powder has strong activity, and the tensile strength can reach 9.913 Mpa when it is formed at 205 °C and 40 min with 50% PP powder. With the help of the low thermal conductivity of the polyurethane foam, the thermal conductivity of the recycled board can reach 0.037 W/m·K at the parameter of 40 mesh, 80%, 185 °C, 30 min. This research provides an effective method for the recycling of polyurethane foam.
Study of the Relationship between Haze Performance and Fractal Dimension in Micro-Sized Segregated Liquid Crystals Embedded in a Polymer Matrix Consisting of a Thiol-ene Prepolymer and a Multi-Functional Acrylate
Authors: Kim Ju-Yong , Choi Suk-Won
Published: December 2021

Micro-sized segregated liquid crystals (MSLCs) surrounded by a polymer medium can be used for haze film applications. When incident light passes through the MSLC film, the microsized particles act as light scattering centers. In this study, the results of the addition of a multi-functional acrylate to a commercial thiol-ene prepolymer system, as well as the morphology of (LC) droplets, fractal dimension (D), and the optical haze performance of the micro-sized segregated LCs formed by UV-initiated photopolymerization, are reported. With increasing fraction of the multi-functional acrylate within the host polymer matrix, the small scattering centers (LC droplets) also increase, giving rise to a large optical haze in the prepared film. The optical haze can be characterized by the D of the associated LC droplet morphology in the films. The optical haze and D exhibit a strong correlation; thus, a qualitative prediction of the optical haze is possible via geometric fractal analysis.
Older Driver Safety: A Renewed Perspective in a Survey Study in Illinois, U.S.
Authors: Pokhrel Roshan , Qi Yan
Published: December 2021

Older adults (aged 65 or older) are at higher risk of involvement in motor vehicle crashes. Many studies have been conducted on older road users’ safety, but how older people’s driving behavior and demographic characteristics, and warnings of side effects of prescription medication, are associated with their crash risk has not been fully investigated. Aimed to address this knowledge gap, a mail survey of older drivers in Illinois, U.S. was conducted. Information on respondents’ driving behaviors, demographic characteristics, physical conditions, medication use, crash experience, etc. was gathered. Response distributions, odds ratios, and logistic regression models were employed to analyze the survey data. The results showed that most respondents kept a high level of mobility despite driving difficulty and medication use. Older drivers’ crash risk is mainly affected by external factors (driving exposure, alcohol consumption, and medication use) rather than their demographic characteristics and driving difficulty. Warnings from physicians on the side effects of prescription drugs had no significant effects on older drivers’ crash risk. Given the importance of mobility to older adults, the focus needs to be placed on providing a safe roadway system and safe driving advice for older drivers, particularly those who are on medication.
Who’s Afraid of Divorce? Sexual Minority Young Adults’ Perspectives on Divorce
Authors: Hoy Aaron , Pokhrel Sachita , Nkwenti Jori Adrianna
Published: December 2021

Research suggests that young adults commonly approve of divorce but still feel anxious about the possibility of divorcing themselves due to anticipated emotional and financial repercussions. However, the existing research focuses exclusively on heterosexual young adults, which is a significant oversight given the recent legalization of same-sex marriage. As such, we rely primarily on qualitative data from an online survey of unmarried sexual minority young adults (n = 257) to examine how they think about divorce. Our results suggest that sexual minority young adults have somewhat distinct perspectives compared to heterosexual young adults. In particular, they anticipate being quite willing to divorce under a broad set of circumstances, and they report minimal anxieties regarding the prospect of divorce. Given documented associations between attitudes toward divorce in young adulthood and subsequent relational behavior (e.g., cohabitation, marital delay), we conclude by discussing what our results suggest about sexual minority young adults’ relationships in the era of marriage equality.
Water Diplomacy and Its Strategic Significance for Sustainable Development Goals and Global Security Architecture
Authors: Krzymowski Adam
Published: December 2021

This article presents new approaches to water diplomacy connected with the United Nations 2030 Agenda. The research question is what is the role and significance of water diplomacy for Sustainable Development Goals (SDGs) and global security architecture? The paper is based on the theory of interdependence. To illustrate this concept, the author used several case studies to identify the international security role of water diplomacy in the context of SDGs. The case studies point to the greater likelihood that wars in the twenty-first century will be due to freshwater disputes; water diplomacy should be a crucial instrument for the SDGs implementation. Water diplomacy has the potential to become an effective platform for international cooperation in the face of many current and future global water challenges. Water diplomacy combines preventive and reactive measures, as well as the mediation and implementation of solutions. It is crucial for regional and world security. The results of this paper show future research directions on water diplomacy.
Using Nano Zero-Valent Iron Supported on Diatomite to Remove Acid Blue Dye: Synthesis, Characterization, and Toxicology Test
Authors: Flores-Rojas Ernesto , Schnabel Denhi , Justo-Cabrera Erick , Solorza-Feria Omar , Poggi-Varaldo Héctor M. , Breton-Deval Luz
Published: December 2021

This work aimed to synthesize and characterize nanoscale zero-valent iron (nZVI), supported on diatomaceous earth (DE) at two different molar concentrations, 3 and 4 M (nZVI-DE-1 nZVI-DE-2), to test the decolorization treatment of acid blue dye (AB) and perform a toxicological test using zebrafish. The synthesis of the nanoparticles was obtained using the chemical reduction method. The material was fully characterized by X-ray diffraction, scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), and transmission electron microscopy and specific surface area (BET). The results showed spherical forms in clusters between 20 and 40 nm of zero-valent iron supported on diatomaceous earth. The removal of 1 g/L of AB from water treated with nZVI-DE-1 and nZVI-DE-2 reached the decolorization of 90% and 98% of all dye. By contrast, controls such as nZVI and DE-1 and DE-2 removed 40%, 37%, and 24% of the dye. Toxicological analysis using zebrafish showed that AB causes a severe defect in development, and embryos die after exposure. However, the water samples treated with nZVI-DE-1 and nZVI-DE-2 are not harmful to the zebrafish embryos during the first 24 h. However, all embryos exposed to the new material for more than 48 hpf had cardiac edema, smaller eyes, and curved and smaller bodies with less pigmentation.
Extended Theory of Planned Behavior for Predicting the Willingness to Pay for Municipal Solid Waste Management in Beijing
Authors: He Jiahao , Yu Zhefan , Fukuda Hiroatsu
Published: December 2021

Municipal solid waste (MSW) management has become a problem in China, mainly since there is no uniform standard for MSW management charges, causing conflict between local residents and the government. An intelligent garbage sorting system (IGSS) is an effective sorting approach for MSW management. To explore the predictors of local residents’ willingness to pay (WTP) for the IGSS, this study applied an extended theory of planned behavior (TPB) model by adding an antecedent environmental concern (EC) prior to the main predictors of the TPB model (attitudes, subject norms, perceived behavioral control). The WTP of Beijing residents for MSW management and the determinants of WTP were analyzed. The specific amount of WTP was predicted by a contingent valuation method (CVM) in an online questionnaire, and the mean WTP was estimated to be USD 49.93 per household per year. The results showed a positive connection between EC and residents’ WTP, and most of the participants were willing to pay for the IGSS for MSW management.
Tourism Market Segmentation Applied to Coastal and Marine Destinations: A Study from Acapulco, Mexico
Authors: Carvache-Franco Mauricio , Carvache-Franco Wilmer , Carvache-Franco Orly , Solis-Radilla María Magdalena
Published: December 2021

Coastal and marine destinations offer alternate options for the sun and the beach, options that are related to nature and culture. This empirical study aims to segment the demand of domestic tourism in coastal and marine destinations and its relationship with satisfaction and loyalty. A factorial analysis and an analysis of K-means clusters were used to reduce and group data. Six motivational dimensions are evident heritage and nature, learning, and sun and beach; and physical, authentic coastal experience, novelty, and social interaction. Two segments were found: the “multiple coastal motives,” which returned a high motivation among the motivational variables proposed and are related to all the factors found, and the “beach lovers”, with high motivation in the aspects of sun and beach, resting, and wanting to see things they do not usually see. These two segments are related to the dimensions of sun and beach and novelty. The multiple coastal motives rendered higher levels of satisfaction and in some variables of future behavior, which shows the relationship of the motivation with the visit. The findings are used to develop marketing plans appropriate to the characteristics of the demand found in each group.
Hubs for Circularity: Geo-Based Industrial Clustering towards Urban Symbiosis in Europe
Authors: Mendez Alva Francisco , De Boever Rob , Van Eetvelde Greet
Published: December 2021

Since the Green Deal, ambitious climate and resource neutrality goals have been set in Europe. Here, process industries hold a unique position due to their energy and material transformation capabilities. They are encouraged to develop cross-sectorial hubs for achieving not only climate ambition, but also joining a circular economy through urban–industrial symbiosis with both business and community stakeholders. This research proposes a data-based approach to identify potential hub locations by means of cluster analysis. A total of three different algorithms are compared on a set of location and pollution data of European industrial facilities: K-means, hierarchical agglomerative and density-based spatial clustering. The DBSCAN algorithm gave the best indication of potential locations for hubs because of its capacity to tune the main parameters. It evidenced that predominately west European countries have a high potential for identifying hubs for circularity (H4Cs) due to their industrial density. In Eastern Europe, the industrial landscape is more scattered, suggesting that additional incentives might be needed to develop H4Cs. Furthermore, industrial activities such as the production of aluminium, cement, lime, plaster, or electricity are observed to have a relatively lower tendency to cluster compared with the petrochemical sector. Finally, further lines of research to identify and develop industrial H4Cs are suggested.
Evaluating the Effectiveness of an Augmented Reality Game Promoting Environmental Action
Authors: Wang Kyra , Tekler Zeynep Duygu , Cheah Lynette , Herremans Dorien , Blessing Lucienne
Published: December 2021

While public awareness of climate change has grown over the years, many people still have misconceptions regarding effective individual environmental action. In this paper, we present a serious game called PEAR, developed using elements of geolocation and augmented reality (AR), aimed at increasing players’ awareness of climate change issues and propensity for effective sustainable behaviours. We conducted a study with participants who played the game, gauging their knowledge of and attitudes towards climate change issues before and after playing the game. Our results show that the game significantly improved participants’ knowledge on sustainability and climate-change-related issues, and that it also significantly improved their attitudes towards these topics, thus proving that serious games have the potential to impart knowledge and promote sustainable behaviours. Additionally, our results address the lack of empirical studies on the knowledge base of serious sustainability games by introducing methods of quantitatively analysing the effects of serious sustainability games while additionally providing more knowledge about the effectiveness of the specific design elements of our game.
Levulinic Acid Production from Macroalgae: Production and Promising Potential in Industry
Authors: Meinita Maria Dyah Nur , Amron Amron , Trianto Agus , Harwanto Dicky , Caesarendra Wahyu , Jeong Gwi-Taek , Choi Jae-Suk
Published: December 2021

The development of macroalgal biorefinery products as an alternative source of renewable fuels is an opportunity to solve the dependence on fossil fuels. Macroalgae is a potential biomass that can be developed as a raw material for producing platform chemicals such as levulinic acid (LA). In the industrial sector, LA is among the top 12 biomass-derived feedstocks designated by the U.S. Department of Energy as a high-value chemical. Several studies have been conducted on the production of LA from terrestrial-based biomass, however, there is still limited information on its production from macroalgae. The advantages of macroalgae over terrestrial and other biomasses include high carbohydrate and biomass production, less cultivation cost, and low lignin content. Therefore, this study aims to investigate the potential and challenge of producing LA from macroalgae in the industrial sector and determine its advantages and disadvantages compared with terrestrial biomass in LA production. In this study, various literature sources were examined using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) method to identify, screen, and analyze the data of the published paper. Despite its advantages, there are some challenges in making the production of levulinic acid from macroalgae feasible for development at the industrial scale. Some challenges such as sustainability of macroalgae, the efficiency of pretreatment, and hydrolysis technology are often encountered during the production of levulinic acid from macroalgae on an industrial scale.
Multiple Understandings of Sustainability among Alternative Food Organizations in Geneva
Authors: González Catalina , Lorenzini Jasmine
Published: December 2021

Alternative Food Organizations (AFOs) seek to establish more sustainable practices in the food system. However, they might hold different conceptualizations of sustainability. Hence, we miss an overview of AFOs’ conceptualizations of sustainability that allows grasping their overall transformative potential. In this paper, we analyze a broad range of AFOs active in food production, distribution, and consumers’ advocacy to examine to what extent they share a common understanding of sustainability. Our empirical analyses focus on the Swiss canton of Geneva, we build on organizational survey data and detailed coding of the discourses published on their websites. We find that the environmental dimension of sustainability is more prominent and that weak and strong conceptualizations of sustainability are equally present in AFOs’ discourses. However, important differences appear between food producers and distributors. The former have a multidimensional and strong conceptualization of sustainability, while the latter focus on fewer dimensions and a weak conceptualization. In spite of these differences, AFOs interact within a small but heterogeneous network.
A Critical Assessment on Functional Attributes and Degradation Mechanism of Membrane Electrode Assembly Components in Direct Methanol Fuel Cells
Authors: Jayakumar Arunkumar , Madheswaran Dinesh Kumar , Kumar Nallapaneni Manoj
Published: December 2021

Direct methanol fuel cells (DMFC) are typically a subset of polymer electrolyte membrane fuel cells (PEMFC) that possess benefits such as fuel flexibility, reduction in plant balance, and benign operation. Due to their benefits, DMFCs could play a substantial role in the future, specifically in replacing Li-ion batteries for portable and military applications. However, the critical concern with DMFCs is the degradation and inadequate reliability that affect the overall value chain and can potentially impede the commercialization of DMFCs. As a consequence, a reliability assessment can provide more insight into a DMFC component’s attributes. The membrane electrode assembly (MEA) is the integral component of the DMFC stack. A comprehensive understanding of its functional attributes and degradation mechanism plays a significant role in its commercialization. The methanol crossover through the membrane, carbon monoxide poisoning, high anode polarization by methanol oxidation, and operating parameters such as temperature, humidity, and others are significant contributions to MEA degradation. In addition, inadequate reliability of the MEA impacts the failure mechanism of DMFC, resulting in poor efficiency. Consequently, this paper provides a comprehensive assessment of several factors leading to the MEA degradation mechanism in order to develop a holistic understanding.
Exploring MOOCs That Promote Innovative Public Services
Authors: Yoshida Masami , Theeraroungchaisri Anuchai , Thammetar Thapanee , Khlaisang Jintavee
Published: December 2021

The promotion and dissemination of a government’s basic policy are essential to implement innovative public services to establish sustainable country development and to ensure that the benefits are shared among citizens. This study focused on the MOOCs project in Thailand, and five courses were selected for exploration. Qualitative content analysis and sentiment analysis were applied to understand how information and communications technology in government services was promoted in the courses. These methods also explained the differences in the content of each course. It turned out that the strategy of improving service quality was the most-emphasized strategy in courses with an explanation of positive sentiment. The number of users who received a positive explanation of improving service quality was estimated at 711 and rated as a satisfactory result. The result of the qualitative content analysis was assembled into groups that could reveal the government’s pleiotropic orientation in their work on basic policy. All of these groups are involved in the international criteria for a government’s digital transformation, and other activities have also been highlighted as future challenges. The possibility of using MOOCs for policy promotion and education is suggested to bridge the gap between Thailand and other countries.
Exact Solutions and Conservation Laws of the Time-Fractional Gardner Equation with Time-Dependent Coefficients
Authors: Li Ruixin , Li Lianzhong
Published: December 2021

In this paper, we employ the certain theory of Lie symmetry analysis to discuss the time-fractional Gardner equation with time-dependent coefficients. The Lie point symmetry is applied to realize the symmetry reduction of the equation, and then the power series solutions in some specific cases are obtained. By virtue of the fractional conservation theorem, the conservation laws are constructed.
Research on Optimization of Urban Public Transport Network Based on Complex Network Theory
Authors: Lin Zhongyi , Cao Yang , Liu Huasheng , Li Jin , Zhao Shuzhi
Published: December 2021

The urban public transportation system is an important part of urban transportation, and the rationality of public transportation routes layout plays a vital role in the transportation of the city. Improving the efficiency of public transportation can have a positive impact on the operation of the public transportation system. This paper uses complex network theory and the symmetry of the up and down bus routes and stations to establish an urban public transit network model and calculates the probability of passengers choosing different routes in the public transit network according to passenger travel impedance. Based on passenger travel impedance, travel path probability and passenger travel demand, the links are weighed, and the network efficiency calculation method is improved. Finally, the public transit network optimization model was established with network efficiency as the objective function and solved by the ant colony algorithm. In order to verify the effectiveness of the model and the solution method, this paper selects areas in Nanguan District of Changchun City for example analysis. The result shows that the efficiency of the optimized network is 8.5% higher than that of the original network, which proves the feasibility of the optimized model and solution method.