bluuebunny/crossref_metadata_2025 huggingface dataset:
Intravenous lipid emulsion for local anaesthetic systemic toxicity in pregnant women: A scoping review
Authors: Tsuji Makoto , Nii Masafumi , Furuta Marie , Baba Shinji , Maenaka Takahide , Matsunaga Shigetaka , Tanaka Hiroaki , Sakurai Atsushi
Published: June 2023

Background
Local anaesthetic systemic toxicity (LAST) is a rare but life-threatening complication that can occur after local anaesthetic administration. Various clinical guidelines recommend an intravenous lipid emulsion as a novel treatment for local anaesthetic–induced cardiac arrest. However, its therapeutic application in pregnant patients has not yet been established. This scoping review synthesises evidence on the efficacy and safety of intravenous lipid emulsion for treating LAST during pregnancy.
Method
We searched electronic databases (Medline, Embase and Cochrane Central Register Controlled Trials) and a clinical registry (lipidrescue.org) from inception to Sep 30, 2022. No restriction was placed on the year of publication or the language. We included any study design containing primary data on maternal patients with signs and symptoms of LAST.
Results
After eliminating duplicates, we screened 8,370 titles and abstracts, retrieving 41 full-text articles. We identified 22 women who developed LAST during pregnancy and childbirth, all presented as case reports or series. The most frequent causes of LAST were drug overdose and intravascular migration of the epidural catheter followed by wrong-route drug errors (i.e. intravenous anaesthetic administration). Of the 15 women who received lipid emulsions, all survived and none sustained lasting neurological or cardiovascular symptoms related to LAST. No adverse events or side effects following intravenous lipid emulsion administration were reported in mothers or neonates. Two of the seven women who did not receive lipid emulsions survived with no neurological or cardiovascular sequelae; however, the other two died.
Conclusion
Studies on the efficacy and safety of lipids in pregnancy are scarce. Further studies with appropriate comparison groups are needed to provide more robust evidence. It will also be necessary to accumulate data—including adverse events—to enable clinicians to conduct risk-benefit analyses of lipids and to facilitate evidence-based decision-making for clinical practice.
Atomic-scale Chemical Imaging of Amphoteric Dopant in Ferroelectric BaTiO3
Authors: Jeong Hyejin , Lee Daehee , Jung Dongjun , Wang Zhipeng , Lee Jung Ho , Oh Sang Ho
Published: June 2023

Dopants are typically added to semiconductors or functional oxides to substitute specific atomic sites and thereby generate electronic and/or ionic charges. In multilayered ceramic capacitors (MLCCs), various dopants are co-doped in ferroelectric BaTiO3 thin films, with each dopant substituting a specific atomic site of BaTiO3 for specific function. In particular, rare-earth elements such as Dy, which have a formal ionic charge of 3+, can act as either electronic donor or acceptor depending on the doping sites. The unique capability of Dy to occupy both Ba (A-site) and Ti (B-site) of BaTiO3, known for its amphoteric behavior, plays a crucial role in the charge transport, which in turn affects the leakage current characteristics governing the reliability of MLCCs. Here we show that the site occupancy of the amphoteric dopant Dy in BaTiO3 can be determined unambiguously through atomic-scale chemical imaging using scanning transmission electron microscopy (STEM) energy dispersive X-ray spectroscopy (EDS). Three types of MLCC devices were investigated, which were made with different BaTiO3 powders synthesized by hydrothermal, co-precipitate, and solid-state reaction methods. Quantitative analysis of the A- and B-site occupancy of 1.4 at% Dy in each sample was systematically conducted using atomic-resolution STEM-EDS. The measured X-ray counts were interpreted quantitatively with the aid of EDS simulation that takes into account the electron channeling effects. The A/B-site occupancy determined for the three samples conforms with their bulk device characteristics with high confidence. This study paves the way for atomic-scale dopant analysis that bridges the bulk characteristics of electronic devices, which helps establish a strategy for the design of doping materials and their processes.
Intra-crustal Mantle in the Himalayan-Tibetan Orogen
Authors: Pilia Simone , Bouilhol Pierre , Menant Armel , Ostorero Léa , Vaes Bram , Esposito Rosario , Garzanti Eduardo , Muller Veleda , Cloetingh Sierd , Gerya Taras , Sternai Pietro
Published: June 2023

The Himalayan-Tibetan mountains raised due to doubling of the continental crust during the India-Asia collision, which is often assumed to have occurred by underthrusting of the Indian crust directly below the Asian crust. However, this model scenario requires very weak continental lithospheres, resulting in a collision system that is difficult to reconcile with several first-order features of the Himalayan-Tibetan orogenic architecture. Here, we present results from a new extensive set of state-of-the-art numerical petrological-thermo-mechanical experiments of continental collision/subduction that account for relatively stiffer plates and generates elevation and first-order structures consistent with observations. In these models, crustal doubling systematically occurs by viscous underplating of the subducting crust underneath the rigid upper-plate lithospheric mantle. The mantellic signature in hydrothermal fluids outflowing the suture zone, the geochemistry of south Tibetan ultramafic magmas and xenoliths, long-wavelength buckling of Tibet, and pre-existing seismological constraints further support the presence of interlayered mantle between the Indian and Asian crusts. The reconciliation of our results with existing geophysical and geological data bears profound implications for our understanding of crustal doubling and mountain building during continental collision/subduction.
A comparative study of the disease burden of COPD attributable to PM2.5 in China, Japan, and South Korea from 1990 to 2019
Authors: Cheng Xiao-Fen , Min Shu-Hui , Guo Rui-Qi , Zhang Jin-Dan , Zhang Yi-Li , Li Bei
Published: June 2023

Background: Particulate matter pollution (PM2.5) is a major cause of air pollution and an important risk factor for chronic obstructive pulmonary disease (COPD). The COPD disease burden situation in East Asia is severe, and China, Japan, and South Korea are the three largest economies in East Asia. We hope to reveal the changing trends of COPD disease burden attributable to PM2.5 and its age, period, and cohort effects in three typical East Asian countries to provide a reference for public health planning.
Methods: We analyzed trends in change based on GBD2019 using JoinPoint regression models and the effect of age, period and cohort on the disease burden of COPD attributable to PM2.5 using age-period-cohort models.
Results: From 1990 to 2019, except for the global age-standardized mortality rate (ASMR) of COPD attributable to ambient particulate matter pollution (APM) for all genders, all other ASMRs showed a downward trend. All were decreasing except for the age-standardized DALY attributed to APM for females in global. Mortality of COPD attributable to PM2.5 increases with age in Korea and Japan. Mortality of COPD attributable to PM2.5 peaks in the 85-90 year age group and then declines in global. Mortality of COPD attributable to PM2.5 in China declines after peaking in the 90-95 year age group. Mortality of COPD attributable to PM2.5 decreased over time in China, Korea, and global, while it increased in Japan from 2015 to 2019. In China, Japan, and global, mortality of COPD attributable to PM2.5 was lower the later the birth, while in Korea it decreased after a small increase in the 1900-1910 cohort.
Conclusion: Most COPD disease burden attributable to PM2.5 is on the decline; Large regional differences in COPD disease burden attributable to PM2.5; The risk of COPD due to HAP and APM differed in different areas; COPD mortality attributable to PM2.5 both increased with age and decreased with time and cohort. Countries in Asia with a high COPD disease burden attributable to PM2.5 should develop targeted measures to control local PM2.5 according to pollutant type and age group to reduce the COPD disease burden caused by PM2.5 according to local conditions.
Association between the triglyceride-glucose index and the risk of cardiovascular disease in Kurdish adult: Result from RaNCD cohort study
Authors: kamari negin , Fateh Hawal Lateef , Darbandi Mitra , Najafi Farid , Bonyani Mitra , Shakiba Ebrahim , Pasdar Yahya
Published: June 2023

Background: The triglyceride-glucose (TyG) index, a consistent content for insulin resistance, has been related to cardiovascular disease (CVD). We aimed to perused the relationship between the TyG index and development of CVD in Kurdish adults.
Methods: In this cross-sectional study, data was used from the Ravansar Noncommunicable Diseases (RaNCD) Cohort Study. Subjects with a history of stroke, myocardial infarction, or coronary artery disease, or who were currently receiving medications for these conditions, were classified as CVD patients.
Results: The research comprised 9723 individuals overall (51.76% of whom were female, mean age 47.3 ±8.26 year). We found that the TyG index in CVD patients (8.82±0.81) was substantially higher than that in non-CVD patients (P=0.001), and the top quartile of the TyG had significantly more BMI (28.73±4.20), TG (239.45±103.30), and FBS (117.85±50.36) values than the lowest quartiles (P=0.001). The TyG and CVD showed a positive association according to the cohort data. The chances of CVD were 2.54 (95% CI: 2.16-2.98) times higher in the fourth tertile of the TYG index than in the first tertile. After controlling for confounding factors, their association was still significant (OR: 1.58, 95%Ci: 1.35-1.95). The predictive value of the TYG score was 63% for females and 57% for males, according to ROC curve research.
Conclusion: According to the findings, risk of cardiovascular disease was linearly correlated with the triglyceride glucose index. Moreover, the TyG may be more accurate predictor of CVD in female.
Improved Tree Dimensional DV-Hop Protocol for Large Scale Range-Free Wireless Sensors Network
Authors: liouane oumaima , Amdouni Rim , Hajjaji Mohamed Ali , ABDELALI Abdessalem BEN
Published: June 2023

Location plays a crucial role in many applications of Wireless Sensor Networks (WSNs), and accurate sensor localization is an important aspect of the acquired data. While connectivity algorithms are commonly used for localizing multi-hop WSNs because their simplicity and acceptable accuracy, their effectiveness can be limited in two-dimensional (2D) or three-dimensional (3D) environments. An analytic model that incorporates hop size quantization and the Recursive Least Squares (RLS) method can be advantageous for Range-Free 3D wireless sensor networks (WSNs) in localization. This approach reduces computational complexity, memory requirements, and localization errors. The third dimension significantly impacts localization accuracy, necessitating the development of effective self-localization algorithms for 3D WSNs. This article introduces a novel probabilistic quantization technique for hop sizes in 3D-WSNs, specifically designed to address the uniform distribution of sensor nodes. The RLS method is employed as an adaptive filtering algorithm to recursively estimate the positions of sensor nodes in the system by minimizing the sum of squared errors between actual measured values and predicted values. Through extensive simulations conducted in isotropic settings under various conditions, the proposed algorithms are evaluated based on their average localization error performance. The simulation data clearly demonstrate that the suggested localization algorithm outperforms previous 3D-DV-Hop heuristics in terms of accuracy. The proposed localization method for 3D-WSNs successfully decreases the average localization error of nodes and achieves superior location accuracy when utilizing predicted hop quantization for hop-size estimation and the RLS algorithm for position estimation compared to competing approaches.
Predicting health effects of food compounds via ensemble machine learning
Authors: Mei Suyu
Published: June 2023

Identifying chemical compounds in foods and assaying their bioactivities significantly contribute to promoting human health. In this work, we propose a machine learning framework to predict 101 classes of health effects of food compounds at a large scale. To tackle skewedness of class distributions commonly encountered in chemobiological computing, we adopt random undersampling boosting (RUSBoost) as the base learner. In this framework, all chemical molecules including food compounds, natural products and drugs are encoded into MACCSKeys similarity spectrums to define the fingerprint similarities of functional subgroups between molecules of interest with predefined template molecules. Five-fold 5-fold cross validation shows that RUSBoost learners encouragingly reduces model biases. Independent tests on external data show that the proposed framework trained on food compounds generalizes well to natural products (0.8406 ~ 0.9040 recall rates for antibacterial, antivirals, pesticide and anticancer effects) and drug molecules (0.789 ~ 0.9690 recall rates for antibacterial, antiviral, antineoplastic and analgesic effects). Furthermore, dozens of novel effects have been validated against recent literature, convincingly demonstrating knowledge transferability between food compounds, plant or microbial natural products and drugs. Especially, evidences show that the proposed framework helps us to repurpose drugs or find lead compounds for anticancer therapies and bacterial drug resistance. Lastly, we attempt to use the proposed framework to unravel beneficial and risky health effects of food flavor compounds, which potentially benefits recipe composing.
Long-term Survival Outcomes in Patients with Locally Advanced Breast Cancer after Total Mastectomy with or without Breast Reconstruction: A Seer-based Analysis
Authors: Heng Zhang , AiJie Zhang , Tingting Wei , Hongbo Huang , Yunhai Li , Fan Li
Published: June 2023

Background: There is ongoing debate about the safety of breast reconstruction for patients with locally advanced breast cancer (LABC) who have undergone total mastectomy (TM). More and more LABC patients are undergoing breast reconstruction after TM, but its long-term survival outcomes remain unclear. This study aims to compare the survival outcomes of LABC patients who underwent breast reconstruction after TM with those who did not, based on a large sample.
Methods: We collected data for all LABC patients who underwent TM with or without breast reconstruction in the Surveillance, Epidemiology, and End Results (SEER) database. We divided patients into two groups: TM group and total mastectomy with reconstruction (TM+R) group. The primary outcomes were overall survival (OS) and breast cancer-specific survival (BCSS). Propensity score matching (PSM) analysis was used to eliminate imbalances of baseline data between the in tow groups. Data were analyzed using chi-square tests, Kaplan-Meier methods, and univariate and multivariate cox regression analyses.
Result: We identified 39,112 eligible patients (33,169 patients received TM and 5,943 received TM+R), and 8,680 patients were matched after PSM (4,340 patients received TM and 4,340 received TM+R). Patients with middle age, white, married, lived in urban, IIB-IIIA stage, invasive ductal carcinoma(IDC), pathological grade II-III, hormone receptor positive, and undergone chemotherapy were more likely to receive breast reconstruction. After PSM, Kaplan-Meier survival analysis showed better OS and BCSS in the TM+R group versus the TM group (OS:P<0.001; BCSS: P=0.008). Multivariate cox regression analysis showed that TM+R significantly improved OS and BCSS (OS: hazard ratio (HR) 0.73, 95% CI [0.68,0.79], P<0.001; BCSS: 95% CI [0.79,0.94], P=0.001). Subgroup analysis showed that patients with old age, white, and hormone receptor positive had better OS and BCSS by TM+R compared to TM.
Conclusions: Breast reconstruction after total mastectomy is associated with better OS and BCSS in patients with LABC.
Uterotubal Junction of the Bovine (Bos taurus) vs. the Dromedary Camel (Camelus dromedarius): Histological and Histomorphometry Analysis
Authors: Abdoon Ahmed Sabry , Soliman Seham S. , Mohamed Ahmed N.
Published: June 2023

This study compares the histomorphology differences of cattle uterotubal junction (CUTJ) and dromedary camels uterotubal junction papilla (CUTJP). UTJ were dissected from eight cows and twelve camels with dominant follicles, and processed for H&E staining for morphology, histology, and histomorphometry examination. The results showed that the CUTJP existed only in camels and was completely absent in cattle. Histologically, CUTJ appears with a star-shaped lumen, and the mucosa lined by a simple columnar epithelium containing ciliated and non-ciliated cells, superficial (SG), and deep glands (D G) were abundant in the submucosa. CUTJP is a fibrous conical structure, it has a pale yellowish color and 0.5 ± 0.2 cm height and 0.3 ± 0.1 cm width. C UTJP, the lumen is wider, and the mucosa showed large multiple folds lined with ciliated and non-ciliated pseudostratified columnar epithelium. The submucosa showed no endometrial glands. Lumen area, lumen epithelial height, luminal epithelial density, the thickness of the muscular layer, number of folds, folds height, epithelial height, fold area, and epithelial perimeter were higher in CUTJP (P < 0.001) than CUTJ. While the total endometrial area and glandular epithelial density were lower in UTJP (P < 0.001) than in CUTJ. In conclusion, the epithelial lining, absence of glands, and the thick layer of tunica muscularis might indicate that camel CUTJP could play a mechanical role in selecting spermatozoa and assisting the hatching of blastocysts during their passage through it.
Using factor analysis to evaluate health related quality of life among patients with Kashin-Beck diseaase in Shaanxi provience, China
Authors: Zhao Yubo , Shi Zhi , Zhang Qingping , Qi Xin , Jia Peng , Yang Shujuan , Chen Ping , Song Yunlong , Liu Jie , Ding Qiongjie , Yang Zhengjun , Cui Chengbao , Wu Qian
Published: June 2023

Background:
Kashin-Beck disease (KBD) is one of the most prevalent endemic diseases in China, causing irreversible damage to the health of patients. Previous studies have mainly focused on the disease’s prevalence rate of KBD, which is not an effective indicator of patients’ health loss. Describing the distribution of health-related quality of life (HRQoL) from different areas and perspectives can better evaluate patients’ health and its influencing factors.
Methods:
Ten representative epidemic areas in Shaanxi Province were selected as the study areas in 2019, and a 36-item Short Form Health Survey (SF-36) was used to investigate the HRQoL of patients. Factor analysis classified indicators into two aspects: physical component summary (PCS) and mental component summary (MCS), evaluating the subjects’ HRQoL. Quantile Regression was used to explore influencing factors.
Results:
Patients with KBD in the northern areas of Shaanxi Province had lower MCS scores, including Huangling County (45.07), Baota District (45.22), and Yaozhou District (45.59). Patients from Yongshou County had the lowest PCS score, with a score of only 41.43. The main factors affecting HRQoL were patients’education level, marital status, and clinical grade. In PCS dimension, patients with an annual household income under 6,000 RMB had higher scores (P10, P25, P50, P75:β = 2.605, 3.308, 2.389, 3.478). In MCS dimension, male had higher scores than female, and the impact of patients who have never received education on their quality of life only had statistical significance in the interval with higher health scores (illiteracy P75, P90: β=-3.952, -3.288; primary level P50, P75: β=-2.274, -3.256).
Conclusions:
This study effectively evaluates the physical and mental health of KBD patients, emphasing the need for consideration of factors affecting patients’ physical activity and psychological well-being in future adjustments. Additionally, it provides important information for eliminating health inequalities and guiding further research.
WITHDRAWN: Seismic Analysis of RC framed Building Situated in High Risk Seismic Zone with Recyclable Scrap Tyre Mix for Base Isolation using Finite Element Modeling
Authors: Raj J. Cici Jennifer
Published: June 2023

Sustainable construction is a key component of the current trend. For civil engineers to master the talent of creating sustainable buildings, recyclable materials must be used. These recyclable waste items from industrial uses must be converted into practical building materials. A number of by-products that are particularly harmful to our environment include scrap tyres as a major ingredient. Used and worn-out automobile tyres could be used in construction as a basic isolation element. These discarded tyres will be utilized as bearings or crumbles for seismic shock absorbers. This paper emphasis the performance of a three-storey RC framed building situated in Nepal with and without scrap tyre crumb mix as base isolation material. The applications of SAP 2000 software package is completely applied for the investigation which is very unique. For instance, the dynamic properties of the building with respect to fixed base (without soil-structure interaction effect is studied) such as base shear, acceleration, displacement and frequencies of the building were studied. Subsequently, the dynamic properties pertaining to the implementation of soil-structure interaction analysis, with and without soil-tyre mix is computed and eventually compared with that of the building without soil-structure interaction criteria. The elegance of this paper is that the analysis has been conducted for five different combinations of tyre crumbs such as 0%, 10%, 20%, 30% and 50%. Furthermore, the investigation has been evaluated for two categories of importance factors such as 1 and 1.2. Moreover, the analysis has been enhanced by further study pertaining to soil conditions such as hard, medium and soft soil as per IS code conditions. From the study it is observed that, 30% tyre crumb combination has superior reduction in base shear, acceleration and frequencies and, increased displacement in all phases of the investigation.
LncRNA MAGI2-AS3 inhibited tumour progression by up-regulating STAM via interacting with miR-142-3p in clear cell renal cell carcinoma
Authors: Yang Riwei , Chen Zude , Ao Shan , Liang Leqi , Chen Zugen , Duan Xiaolu , Zeng Guohua , Deng Tuo
Published: June 2023

Background:
Non-coding RNA (ncRNA) is a class of RNAs that do not encode proteins but have multiple biological functions intracellular. They play an indispensable role in the occurrence and development of tumour. Therefore, understanding their molecular regulatory mechanisms in tumour cells are important for the treatment of tumour patients.
Methods:
The upstream ncRNAs of STAM were predicted by bioinformatic analysis, and the specific mechanism of lncRNA MAGI2-AS3 regulated miR-142-3p affecting STAM expression and participating in ccRCC cell proliferation, invasion, migration and apoptosis was detected by RT-qPCR, Western blotting, cellular functional experiments and luciferase reporter assay.
Results:
Overexpression of miR-142-3p or silencing of MAGI2-AS3 promoted the proliferation and migration of ccRCC cells, and inhibits cell apoptosis, while silencing of miR-142-3p or overexpression of MAGI2-AS3 had the opposite effect on ccRCC cells. Furthermore, we confirmed that MAGI2-AS3 acted as sponge and combined with miR-142-3p, blocked the inhibitory effect of miR-142-3p on the expression of STAM, thereby involved in ccRCC proliferation and metastasis. Furthermore, the prognostic model based on the MAGI2-AS3/miR-142-3p/STAM axis further emphasizes its prognostic value in ccRCC.
Conclusion:
MAGI2-AS3 competitively binding miR-142-3p to upregulate the STAM expression suppressing ccRCC proliferation and metastasis. MAGI2-AS3/miR-142-3p/STAM axis may serve as a promising ccRCC therapeutic target.
Prevalence, Characteristics, and Correlates of Avoidant/Restrictive Food Intake Disorder among Adult Respondents to the National Eating Disorders Association Online Screen: A Cross-Sectional Study
Authors: D'Adamo Laura , Smolar Lauren , Balantekin Katherine , Taylor C. Barr , Wilfley Denise , Fitzsimmons-Craft Ellen
Published: June 2023

Background
Avoidant/restrictive food intake disorder (ARFID) is a serious, albeit under-researched, feeding or eating disorder. This exploratory study utilized data from adult respondents to the National Eating Disorders Association (NEDA) online eating disorder screen to validate items assessing the presence of ARFID and examine the prevalence, clinical characteristics, and correlates of a positive ARFID screen compared to other probable eating disorder/risk categories.
Methods
Among 47,705 adult screen respondents between January 2022 and January 2023, the prevalence of a positive ARFID screen was calculated. Chi-square tests and t-tests compared demographics, eating disorder attitudes and behaviors, suicidal ideation, current eating disorder treatment status, and eating disorder treatment-seeking intentions between respondents with possible ARFID and other eating disorder diagnostic and risk categories. Clinical characteristics of respondents with possible ARFID were also examined.
Results
2,378 (5.0%) adult respondents screened positive for ARFID. Respondents with possible ARFID tended to be younger, male, and have lower household income, and were less likely to be White and more likely to be Hispanic/Latino than most other diagnostic/risk groups. They had lower weight/shape concerns and eating disorder behaviors than all other diagnoses but higher BMI than those with AN. 35% reported suicidal ideation, 47% reported intentions to seek treatment for an eating disorder, and 2% reported currently being in treatment. The most common clinical feature of ARFID was lack of interest in eating (80%), followed by food sensory avoidance (55%) and avoidance of food due to fear of aversive consequences (31%).
Conclusions
Findings from this study indicated that ARFID was prevalent among adult screen respondents and more common among individuals who were younger, male, non-White, Hispanic, and lower income relative to those with other eating disorders or at risk for an eating disorder. Individuals with possible ARFID frequently reported suicidal ideation and were rarely in treatment for an eating disorder. Further research is urgently needed to improve advances in the assessment and treatment of ARFID and improve access to care in order to prevent prolonged illness duration.
Liensinine and neferine exert neuroprotective effects via the autophagy pathway in transgenic Caenorhabditis elegans
Authors: Wu Mengchen , Gao Ye-Hui , Zhang Chen , Ma Bo-Tian , Lin Hong-Ru , Jiang Jin-Yun , Xue Meng-Fan , Li Shan , Wang Hong-bing
Published: June 2023

Liensinine and neferine are the main bisbenzylisoquinoline alkaloids obtained from the seeds of Nelumbo nucifera, which commonly used as edible food and traditional medicine in Asia. It was reported that liensinine and neferine could inhibit the activities of acetylcholinesterase and cross the blood-brain barriers, maybe promising candidates to treat Alzheimer’s disease. Here we employed the APPswe transfected SH-SY5Y neural cells and transgenic Caenorhabditis elegans to investigate the neuroprotective effects and underlying mechanism of liensinine and neferine. Finally, we found that liensinine and neferine could significantly improve the viability and reduce ROS levels in APPswe cells, inhibit β-amyloid and tau-induced toxicity, and enhance stress resistance in nematodes. Moreover, liensinine and neferine had obviously neuroprotective effects by assaying chemotaxis, 5-hydroxytryptamine sensitivity and the integrity of injured neurons in nematodes. Preliminary mechanism studies revealed that liensinine and neferine could upregulate the expression of autophagy related genes (lgg-1, unc-51, pha-4, atg-9 and ced-9) and reduce the accumulation of β-amyloid induced autophagosomes, which suggested autophagy pathway played a key role in neuroprotective effects of these two alkaloids. Altogether, our findings provided a certain working foundation for the use of liensinine and neferine to treat Alzheimer’s disease based on neuroprotective effects.
The Influence of Interactions Between Two High-Rise Buildings on the Wind-Induced Moment
Authors: Yadav Himanshu , Roy Amrit Kumar , Kumar Anoop
Published: June 2023

The purpose of the study was to explore the interference effects on the wind-induced moment caused by two nearby high-rise structures. In order to use computational fluid dynamics (CFD), a stiff full-scale model of the buildings was created. Numerous wind incidence angles and two alternative model cross sections were used in the investigation. Additionally, it was looked at how building heights and aspect ratios affected interference effects. The findings showed that when there was a close proximity between the structures, the interference effects on the wind-induced moment were most noticeable. The study also showed that interference effects were more evident for structures with greater aspect ratios. The degree of interference effects was also greatly influenced by the angle of wind incidence, with perpendicular wind directions having the greatest effects. These results underline how crucial it is to carefully examine the positioning and orientation of high-rise structures when making wind-induced moment designs. To ensure structural stability and reduce potential negative impacts from interference, designers and engineers should consider the proximity of neighboring structures, the aspect ratios of the buildings, and the angle at which the wind strikes the buildings. In wind-prone places, high-rise buildings' safety and performance can be greatly improved by include such factors in the design process.
Clinical profile and factors affecting prognosis in leptospirosis: A retrospective study from a tertiary care center in rural Karnataka
Authors: C Manasa Dixit , K Prabhakar , P Praveen
Published: June 2023

Purpose
To optimize the management of leptospirosis, it is crucial to have a comprehensive understanding of the disease characteristics, ICU needs, and mortality rates associated with the disease.
Methods
The retrospective observational study included patients between 1st April 2021 and 31st March 2022 in the Department of general medicine, at R.L Jalappa Hospital, India. The study collected clinical and laboratory parameters, as well as the Sequential Organ Failure Assessment (SOFA) score, within the first 24 hours of admission. The outcome at discharge was considered, and a prediction model was constructed using regression analysis.
Results
The study included 61 patients with a mean age of 36.79 years. Patients with abnormal respiratory findings during clinical evaluation were more likely to require ICU care. A significantly high mortality rate was observed among patients who needed ICU care. Furthermore, a significant difference in the SOFA score, calculated within the first 24 hours of hospital admission, was observed between deceased and recovered patients. The predictors of mortality, as evaluated by regression analysis, included the SOFA score, abnormal respiratory findings in the clinical examination, and the Coagulation component of the SOFA score.
Conclusion
Abnormal respiratory findings, altered sensorium, total white blood cell (WBC) counts, and the coagulation component of the score were identified as significant predictors of ICU requirement. In leptospirosis, the SOFA score, particularly the coagulation component, and the abnormal respiratory system findings were found to be predictors of outcome. These factors can be easily assessed even in resource-poor settings to prognosticate patients with leptospirosis.
Yoga therapy versus usual care on health-related quality of life in adults with chronic illness: A systematic review
Authors: Nirwan Mohit , Saha Mantu
Published: June 2023

Health-related Quality of Life (HRQoL) is often found to be poor in patients with systemic diseases like Diabetes Mellitus (DM), Chronic Obstructive Pulmonary Disease (COPD), Myocardial Infarction (MI), and cancer. Yoga intervention in clinical research seems to be effective to explore its’ beneficial effects to improve patient’s quality of life suffering from chronic illnesses. It was tried to examine and summarize available evidence through a systematic review that yoga exerts positive effects on patients’ QoL. RCTs were included that explored yoga’s effect on QoL for patients suffering from chronic illness. RCTs with at least 8 weeks of yoga intervention were included. Electronic databases were systematically searched to filter RCTs as per the pre-defined inclusion criteria. RoB2 was used to assess the risk of bias in the selected studies. Published validated QoL questionnaire was the eligible and primary outcome. Among the 1830 studies that were identified initially, 12 studies met all the inclusion criteria. Four studies informed a significant improvement in QoL scores in patients in the yoga arm compared to the usual care group. There was heterogeneity among the included studies and most studies raised ‘some concerns’ about the risk of bias. There is not enough evidence to prove that yoga does improve QoL in patients which is statistically and clinically relevant. Low adherence and compliance to the yoga intervention in the patients and the absence of high-quality RCTs may be the reason. All the studies concluded that yoga is beneficial, safe, and feasible for patients.
Modeling the Impact of Hydraulic Reconnection on Estuary Hydrodynamics
Authors: Kramer Megan , Arias Mauricio E.
Published: June 2023

Coastal environments around the globe are subject to anthropogenic stresses due to dense coastal populations. The response of development activities on dynamic estuarine ecosystems, influenced by tidal forces, freshwater flows, salinity variations, and intricate coastal land morphology, is often uncertain. This case study evaluates how connectivity and coastal geomorphology influence flow patterns by modeling the effects of a proposed hydraulic reconnection project on water movement between the Manchester Waterway, a coastal residential community, and Charlotte Harbor, a large open water estuary in the Gulf of Mexico. An unstructured grid, 2D model was developed utilizing Delft3D Flexible Mesh to simulate estuary hydrodynamics under proposed conditions for four different weather conditions, including recorded 2021–2022 weather, future sea level rise, an extreme weather event, and a combination of extreme weather and sea level rise. Simulated flow results for proposed conditions were compared to present day flow patterns for analysis of the predicted changes in water levels and velocity magnitudes in the waterway. The results show that increased connectivity between the Manchester Waterway and Charlotte Harbor is expected to increase tidal amplitudes largely due to a lowering of minimum water levels in the waterway. During storm events, water elevations are predicted to drop to lower elevations following peak storm surge due to proposed conditions, which may provide flooding relief. Model simulation results will aid hydraulic reconnection and guide a more comprehensive ecological restoration plan. This case study will also improve understanding of the major influencing forces in intricate estuarine environments and how ecosystems may respond to land development, sea level rise, and increasing magnitude and frequency of tropical storms.
Hidden-orders of uranium compounds
Authors: Harima Hisatomo
Published: June 2023

Hidden order is often discussed in strongly correlated electron systems. In many cases, it shows no magnetic responses, so that the order parameter is electric, but accompanies few lattice distortion. In the Jahn-Teller cases, the ordered state gains its energy by changing inter-site mixing strengths, leading a larger structural distortion with lowering symmetry. On the contrary, in strongly correlated electron systems, the strong intra-site Coulomb energy causes the the symmetry lowering. It is not necessary to bring the lattice distortion for lowering local site symmetry. In fact, lower symmetry of electronic state than the symmetry of the crystal structure can be found for UTe_22, UGe_22 similarly for URu_22Si_22.
AUKUS, o submarino de propulsão nuclear brasileiro e as implicações para o regime de não proliferação nuclear
Authors: Viana Souza Guimaraes Victoria , Tossini João Vitor
Published: June 2023

Em 2021, Austrália, Estados Unidos e Reino Unido anunciaram a formação de uma parceriade segurança. Assim, Austrália e Brasil poderiam se tornar estados sem armas nucleares,mas com submarinos de propulsão nuclear. O objetivo é identificar as consequências dadecisão desses países para o Tratado de Não Proliferação de Armas Nucleares (NPT) e osistema de salvaguardas da Agência Internacional de Energia Atômica (AIEA). A metodologiaconsistiu na revisão de literatura e no método comparativo. Concluiu-se que as principaisconsequências estão relacionadas com as salvaguardas da AIEA, a proliferação nuclear eo reforço das desigualdades dentro do TNP.
Managing the quality of functional surfaces and the processing performance products of the ceramic materials on the polishing operations of fixed abrasive
Authors: Kai Jian Ding
Published: June 2023

The theoretical and experimental results of the investigation of fixed abrasive polishing of ceramic are presented in the paper. The equations of the intensity of dispersion allowing to assess the performance and the accuracy of shaping by using related technological environment and the geometry of the lapping are given in the article.
THE NEGATIVE IMPACT OF THE CORONAVIRUS PANDEMIC ON THE GLOBAL ECONOMY AND ECONOMIC PARTNER COUNTRIES OF UZBEKISTAN
Authors: Bekmukhumedova Barno Uktamovna , Odilbekov Akhadbek
Published: June 2023

The article refers to the fact that, in order to mitigate the negative effects of the global crisis on the social and economic development of republic, the President of the Republic of Uzbekistan «On the first priority measures to mitigate the negative impact of the coronavirus pandemic and global crisis on economic sectors» and «Cornovirus pandemic» «On additional measures to support the population, economic sectors and business entities» was adopted and is being put into practice.
FEATURES OF LEGAL REGULATION OF FARMS
Authors: Chetaeva Kristina Aleksandrovna
Published: June 2023

The article outlines the problems and features of the legal regulation of farms created under the law that has become invalid, and also offers recommendations that will eliminate the inconsistency of the legal status of designated farms with the current law and provide a regulatory framework for the continuation of their activities, taking into account the peculiarities of their education.
Queuing system without queue and deterministic service time
Authors: Tsitsiashvili G. Sh. , Radchenkova T. V.
Published: June 2023

Today, queueing systems that describe failures in the process of software testing are subject to extensive research. Such systems involve a dependence between the rate of an input Poisson stream and the rate of exponentially distributed handling time. Using this dependence, system load levelling procedures are defined. However, such a model and method of research are not suitable for systems with a deterministic handling time. Therefore, this paper examines the dependence of the Poisson distribution parameter of the number of requests in a system from the deterministic handling time in the presence of a peak rate of the input stream. This dependence is examined analytically and numerically. It is shown that a reduction of the handling time levels the peak number of customers in the system
Turbidity peaks in the Font de Dins of Peñíscola: a tool to determine recharge areas and transit periods. Aquifer of El Maestrazgo (Castellón)
Authors: Domínguez Sánchez Jose Antonio , Sánchez-Rubio Ruiz Belén
Published: June 2023

El Maestrazgo is a karstic aquifer of more than 2,400 km 2 that occupies the northern half of the province of Castellón. Its main discharge area is in the coastal mountains of Irta. One of the most important springs in the system is the Font de Dins of Peñíscola, which is characterized by its fresh water channeled through preferential circulation channels without contact with sea water. After intense rainfall events, both on a local and regional scale, the usual hydrochemistry of these waters changes almost immediately and remains altered for days or weeks, being able to present stages of marked turbidity. This fact is due to the rapid influx to this upwelling of infiltrated waters in different sectors of the aquifer that significantly increase its flow. This article analyzes the cause-effect relationship of the turbidity peaks that sporadically occur in the Font de Dins spring with very intense or prolonged rains in the area. Once the relationship has been verified, a space-time study allows turbidity to be used as a natural tracer and to establish transit periods, groundwater flow velocities and recharge areas.
Environmental recovery of As Pontes mine pit lake
Authors: Rivas Francisco , Samper Javier , Montenegro Luis
Published: June 2023

One of the most common solutions for more than 50 years for the recovery of mine holes generated during mining activities is their transformation into lakes. This paper presents the activities carried out from the closure of the As Pontes mine to the total filling of the mining lake. The environmental solution adopted for the recovery of the mining hole and its transformation into a mining lake is described, as well as the methodology followed for its filling, defining the water sources used, its volume and its chemical quality. Perfect mix and stratified lake models were performed to simulate the final chemical quality of the lake. The details of the studies carried out on waves on the shores of the lake and the stability of the slopes of the mine are also presented. The hydraulic works carried out to reintegrate into the lake the watercourses that were diverted during the mining exploitation are also indicated. Water chemical data of the As Pontes lake collected during and after the filling of the lake show the presence of two well-differentiated zones separated by a chemocline. The uppermost layer has a slightly acid pH and oxic conditions, while the deeper layer has very low pH values and anoxic conditions. The  methodology used was successful and the forecasts made are in line with the results obtained both in relation to the filling time of the lake and the quality of the overflow waters, which comply with all the established limits.
AVALIAÇÃO DA ESTRUTURA DE TRANSFERÊNCIA DE TECNOLOGIA EM INSTITUIÇÕES CIENTÍFICAS, TECNOLÓGICAS E DE INOVAÇÃO DA REGIÃO NORDESTE DO BRASIL
Authors: Gordilho Leite Diego José Santana , Bezerra Edson Santana , Da Silva Neto Fernando Patrício , Silva Luan Carlos Santos
Published: June 2023

A transferência de tecnologia é um importante mecanismo para potencializar o desenvolvimento das universidades e instituições de ensino e pesquisa. O objetivo deste trabalho consistiu em analisar a transferência de tecnologia das Instituições Científica, Tecnológica e de Inovação do Brasil, sendo este trabalho pautado na Região Nordeste do país, identificando as lacunas existentes para propor melhorias para a gestão dos Núcleos de Inovação Tecnológica no que tocante à transferência de tecnologia e inovação. O estudo é considerado aplicado e exploratório, como método, foi aplicado um questionário com 33 perguntas sobre o tema para os gestores de tecnologia das universidades. Os resultados apontam que as instituições vêm se desenvolvendo em algumas dimensões, como pessoas, cultura e relacionamento, mas necessitam melhorar suas dimensões de comercialização, meio ambiente, sociedade e valoração. Este diagnóstico pode servir de base para tomada de decisão dos gestores públicos, objetivando entender melhor suas capacidades internas e externas, bem como, elaborar melhores estratégias para desenvolvimento de um ambiente acadêmico empreendedor.
MATURIDADE DA DISSEMINAÇÃO DO CONHECIMENTO DA PROPRIEDADE INTELECTUAL EM RELAÇÃO AOS PEQUENOS EMPREENDEDORES
Authors: Alves Gomes Rolim Amanda , Luís Diego Sousa e Silva  , Francisco Fábio Cavalcante Barros  , Joelia Marques de Carvalho
Published: June 2023

O estudo desenvolvido neste artigo, tem como objetivo avaliar a maturidade do conhecimento sobre o uso da propriedade intelectual por parte dos pequenos empreendedores e analisar a disseminação deste uso da PI em um contexto geral. Ademais, serão apresentadas ações que visem ampliar os conhecimentos e aplicações da propriedade intelectual para os pequenos empreendedores, anlisando todo um contexto de empreendedorismo, principalmente no quesito por oportunidades e por necessidade. É sabido que há uma grande parcela da sociedade, em específico o alvo da pesquisa, no caso os pequenos empreendedores, que não conhecem a importância dos direitos e deveres relativos à propriedade intelectual, além do seu benefício em desenvolvimento de novos produtos tecnológicos, bem como a proteção jurídica dos ativos intangíveis, como marcas, patentes, desenhos industriais, indicações geográficas, direitos autorais.  Foram utilizadas na produção do artigo, a metodologia qualitativa e quantitativa, através da obtenção de dados oriundos de pesquisas exploratórias. Os dados coletados foram analizados por meio das pesquisas exploratórias por meio de artigos e dados de órgãos públicos, e descritos ao longo da produção. Ademais, será disposto como esse nível de conhecimento e eventuais usos do sistema de PI estão sendo realizados, bem como vem impactanto a utilização desses conhecimentos nas atividades desses empreendedores, pois a inovação quando adequadamente estimulada contribui para o processo de geração de riquezas e consequentemente uma melhor qualidade de vida da população.
FEIRA DA SABERES E SABORES DA UNIVERSIDADE ESTADUAL DE FEIRA DE SANTANA
Authors: José Raimundo Oliveira Lima  , Eduardo José Fernandes Nunes  , Ana Regina Messias  , Camila Menezes Souza  , Janahína da Silva Moura
Published: June 2023

A Feira de Saberes e Sabores da Universidade Estadual de Feira de Santana (UEFS) nasceu de um projeto de Economia Popular e Solidária em processo de incubação pela Incubadora de Iniciativas de Economia Popular e Solidária da UEFS. Um dos seus principais atributos tem sido pensar-se de forma coletiva e autogestionária, na perspectiva de ser uma Rede de Economia Popular e Solidária que agrega parceiros participantes, e não um simples mercado consumidor. Nesse sentido, objetivamos fazer uma reflexão sobre a Feira de Sabres e Sabores considerando que ela é uma rede que se amplia nas diversas dimensões da Economia Popular e Solidária, mas que, ao mesmo tempo, é permeada pelas possibilidades de submissão direta e simples ao mercado. Metodologicamente, utilizamos os preceitos da pesquisa-ação, e elaboramos um roteiro de entrevistas de onde foram extraídos os dados analisados. Durante a análise, algumas categorias foram prioritariamente trabalhadas, como informações básicas sobre precificações, regras de convivência, bem como a compreensão da organicidade entre os que produzem, os que consomem e os que produzem/consomem. Concluímos que todos os envolvidos na Feira de Saberes e Sabores da UEFS são feirantes ou potenciais feirantes que têm formado uma identidade social compromissada e consciente em relação ao consumo. Esse público possibilita a experimentação de um novo formato de trocas, produção da existência e criação de valor social local que se fundamenta na utilização das atuais tecnologias livres. Dessa forma, articulam e melhoram as relações coletivas, por vezes conflitantes quanto ao mercado, mas, resistentes, associativas, comunitárias e solidárias.