bluuebunny/crossref_metadata_2025 huggingface dataset:
Robust single frequency index-patterned laser design using a Fourier design method: supplemental document
Authors: Boohan Niall , Corbett Brian , O'Reilly Eoin
Published: March 2023

This document provides supplemental information for the paper “Robust single frequency index-patterned laser design using a Fourier design method”. We present in Sec. S1 a modelling comparison between the results of the first-order Fourier method that we use and a transfer matrix method (TMM) that includes all orders of scattering, showing that the results of the first-order Fourier method are in excellent agreement with the results of the TMM calculation. Sec. S2 then provides a detailed description of the theory of perturbation scattering used in our modelling. This is followed in Sec. S3 by a mathematical analysis showing that slot patterns which are a greater weighted average distance from the centre of the cavity select their chosen mode (m_0) more strongly. Finally we present an example in Sec. S4 of how our results are modified when a temperature dependent gain spectrum is included in the analysis.
Indenyl-thiazole and indenyl-formazan derivatives: Synthesis, anticancer screening studies, molecular-docking, and pharmacokinetic/ molin-spiration properties
Authors: Alfaifi Ghaidaa H. , Farghaly Thoraya A. , Magda H. Abdellattif
Published: March 2023

Two new series of thiazole and formazan linked to 5-Bromo-indan were synthesized, and their structures were assured based on all possible analytical techniques. The size of the tested derivatives was calculated from the XRD technique and found five derivatives 3, 10a, 14a, 15, and 16 on the nanosized scale. The two series were tested for their efficacy and toxicity as anti-colon and stomach cancers. Derivative 10d showed activity more than the two reference drugs used in the case of SNU-16. Surpislly, in the case of COLO205, five derivatives 4, 6c, 6d, 6e, and 10a are better than the two benchmarks used, and two derivatives, 14a and 14b more potent than cisplatin. All potent derivatives showed a strong fit with the active site of the two tested proteins (gastric cancer (PDB = 2BID) and colon cancer (PDB = 2A4L)) in the molecular docking study. The Pharmacophore and ADME studies of the new derivatives showed that most derivatives revealed promising bioactivity, which indicates the drug-likeness properties against kinase inhibitors, protease, and enzyme inhibitors. In addition, the ProTox-II showed that the four compounds 10d, 16, 6d, and 10a are predicted to have oral LD50 values ranging from 335 to 3500 mg/kg in a rat model with (1 s,4 s)-Eucalyptol bearing the highest values and quercetin holding the lowest one.
Clinical characteristics of sarcoma cases in which long-term disease control was achieved with trabectedin treatment: A retrospective study
Authors: Ohmoto Akihiro , Nakano Kenji , Fukuda Naoki , Wang Xiaofei , Urasaki Tetsuya , Hayashi Naomi , Suto Hirotaka , Udagawa Shohei , Oki Ryosuke , Sato Yasuyoshi , Yunokawa Mayu , Ono Makiko , Saito Masanori , Minami Yusuke , Hayakawa Keiko , Tanizawa Taisuke , Ae Keisuke , Matsumoto Seiichi , Tomomatsu Junichi , Takahashi Shunji
Published: March 2023

Trabectedin is a therapeutic option for patients with advanced sarcoma. While a randomized trial demonstrated its prolonged progression-free survival (PFS), the reported PFS was <6 months. Some patients can achieve long-term disease control with this treatment. However, the reference information is insufficient. Herein, we retrospectively reviewed 51 sarcoma patients who received trabectedin. We analyzed the clinicopathological features, trabectedin dose, administration schedule, and clinical outcomes, including the overall response rate (ORR) and PFS. Among them, we assessed the detailed data of patients who achieved long-term disease control (PFS >1 year). The ORR in the 49 evaluable patients was 8%, and the median PFS in 51 patients was 7.5 months. Six patients (12%) achieved PFS of >1 year. Five of the six patients had metastatic lesions at trabectedin initiation. The pathological subtypes were myxoid liposarcoma (n = 2), leiomyosarcoma (n = 2), synovial sarcoma (n = 1), and Ewing sarcoma (n = 1). The final administration dose was the minimum dose (0.8 mg/m2) in two patients who continued the treatment over 20 cycles. The best radiological response was partial response (PR) in two myxoid liposarcoma patients and stable disease in four. The durations from trabectedin initiation to the first response in the two PR cases were 163 and 176 days, respectively. Our results support the validity of continuing trabectedin at a sustainable dose and interval in patients who can tolerate it. These results may be useful when considering the clinical application of trabectedin.
Heat-related mortality in U.S. state and private prisons: A case-crossover analysis
Authors: Skarha Julianne , Spangler Keith , Dosa David , Rich Josiah D. , Savitz David A. , Zanobetti Antonella
Published: March 2023

Rising temperatures and heatwaves increase mortality. Many of the subpopulations most vulnerable to heat-related mortality are in prisons, facilities that may exacerbate temperature exposures. Yet, there is scare literature on the impacts of heat among incarcerated populations. We analyzed data on mortality in U.S. state and private prisons from 2001–2019 linked to daily maximum temperature data for the months of June, July, and August. Using a case-crossover approach and distributed lag models, we estimated the association of increasing temperatures with total mortality, heart disease-related mortality, and suicides. We also examined the association with extreme heat and heatwaves (days above the 90th percentile for the prison location) and assessed effect modification by personal, facility, and regional characteristics. There were 12,836 deaths during summer months. The majority were male (96%) and housed in a state-operated prison (97%). A 10°F increase was associated with a 5.2% (95% CI: 1.5%, 9.0%) increase in total mortality and a 6.7% (95% CI: -0.6%, 14.0%) increase in heart disease mortality. The association between temperature and suicides was delayed, peaking around lag 3 (exposure at three days prior death). Two- and three-day heatwaves were associated with increased total mortality of 5.5% (95% CI: 0.3%, 10.9%) and 7.4% (95% CI: 1.6%, 13.5%), respectively. The cumulative effect (lags 1–3) of an extreme heat day was associated with a 22.8% (95% CI: 3.3%, 46.0%) increase in suicides. We found the greatest increase in mortality among people ≥ 65 years old, incarcerated less than one year, held in the Northeast region, and in urban or rural counties. These findings suggest that warm temperatures are associated with increased mortality in prisons, yet this vulnerable population’s risk has largely been overlooked.
A comparative study of the COVID-19 vaccine efficacy among cancer patients: mRNA versus non-mRNA
Authors: Rachman Andhika , Iriani Anggraini , Sukrisman Lugyanti , Rajabto Wulyo , Mulansari Nadia Ayu , Lubis Anna Mira , Cahyanur Rahmat , Prasetyawati Findy , Priantono Dimas , Rumondor Bayu Bijaksana , Betsy Rachelle , Juanputra Samuel
Published: March 2023

Background

Cancer patients have an increased risk of a severe COVID-19 infection with higher mortality rate. This study aimed to analyze the levels of anti-SARS-CoV-2 S-RBD IgG and NAB among cancer patients who were vaccinated with COVID-19 vaccines, either with BNT162b2, mRNA-1273, AZD1222/ChAdOx1nCoV-19, or Coronavac/BBIBP-CorV vaccines.

Method

A cross-sectional study was conducted among subjects with either solid or hematological cancers who had received two doses of either mRNA or non-mRNA vaccines within 6 months. The levels of anti-SARS-CoV-2 S-RBD IgG and NAb were analyzed using the Mindray Immunoassay Analyzer CL-900i. Statistical analysis was conducted using mean comparison and regression analysis.

Result

The mRNA-1273 vaccine had the highest median levels of S-RBD IgG and NAb, followed by BNT162b, ChAdOx1nCoV-19, and BBIBP-CorV/Coronavac. The levels of S-RBD IgG and NAb in subjects vaccinated with mRNA vaccines were significantly higher than those of non-mRNA vaccines when grouped based on their characteristics, including age, type of cancer, chemotherapy regimen, and comorbidity (p<0.05). Furthermore, the S-RBD IgG and NAb levels between the subjects vaccinated with non-mRNA vaccines and the subjects vaccinated with mRNA vaccines were significantly different (p<0.05). However, there was no significant difference between the same types of vaccines. This study demonstrated a very strong correlation between the level of S-RBD IgG and the level of NAb (R = 0.962; p<0.001). The level of anti-SARS-CoV-2 S-RBD IgG was consistently higher compared to the level of NAb.

Conclusions

Generally, mRNA vaccines produced significantly higher anti-SARS-CoV-2 S-RBD IgG and NAb levels than non-mRNA vaccines in cancer subjects.
Fat digestion using RELiZORB in children with short bowel syndrome who are dependent on parenteral nutrition: Protocol for a 90-day, phase 3, open labeled study
Authors: Tsikis Savas T. , Fligor Scott C. , Mitchell Paul D. , Hirsch Thomas I. , Carbeau Sarah , First Eric , Loring Greta , Rudie Coral , Freedman Steven D. , Martin Camilia R. , Gura Kathleen M. , Puder Mark
Published: March 2023

Background

Short bowel syndrome (SBS) is a leading cause of intestinal failure resulting in parenteral nutrition (PN) dependence and nutritional deficiencies. Long-term PN use is associated with the development of sepsis and intestinal failure-associated liver disease. Achieving enteral autonomy is the optimal way to prevent these complications. In SBS, the decreased intestinal length, bile acid deficiency, and rapid transit time contribute to fat malabsorption and continued PN dependence. We propose the use of an immobilized lipase cartridge (ILC; RELiZORB) that connects in-line with enteral feed tubing sets and is designed to breakdown the majority of fats provided in enteral nutrition (EN). Preclinical studies have demonstrated both improved fat and fat-soluble vitamin absorption with ILC use in a porcine model of SBS. To evaluate the clinical applicability of these findings, we designed a phase 3, open labeled, single center, clinical trial to determine the safety, tolerability, and efficacy of the RELiZORB enzyme cartridge when used daily with EN for 90 days.

Methods

The patient population will include PN dependent children with SBS, aged 2–18 years. The primary outcome is the change in PN calories from baseline, assessed weekly throughout the study. Changes in growth Z-scores, 72-hour fecal fat and coefficient of fat absorption, plasma fatty acids and fat-soluble vitamins will also be evaluated. Assessment of change in continuous outcomes will be made using the area under the curve, expressed as a percent change relative to baseline, calculated over study day 7 to 90 (AUC7-90). The incidence of adverse events will be monitored and summarized by system organ class.

Discussion

If successful, RELiZORB may offer a safe alternative to reducing PN dependence and achieving enteral autonomy in pediatric intestinal failure. These results would be clinically significant given the clear association between long-term PN use and complications in SBS.

Trial registration

ClinicalTrials.gov NCT03530852; registered on May 21st, 2018, last update posted on September 14th, 2022.
Machine learning-based prediction of intraoperative hypoxemia for pediatric patients
Authors: Park Jung-Bin , Lee Ho-Jong , Yang Hyun-Lim , Kim Eun-Hee , Lee Hyung-Chul , Jung Chul-Woo , Kim Hee-Soo
Published: March 2023

Background

Reducing the duration of intraoperative hypoxemia in pediatric patients by means of rapid detection and early intervention is considered crucial by clinicians. We aimed to develop and validate a machine learning model that can predict intraoperative hypoxemia events 1 min ahead in children undergoing general anesthesia.

Methods

This retrospective study used prospectively collected intraoperative vital signs and parameters from the anesthesia ventilator machine extracted every 2 s in pediatric patients undergoing surgery under general anesthesia between January 2019 and October 2020 in a tertiary academic hospital. Intraoperative hypoxemia was defined as oxygen saturation <95% at any point during surgery. Three common machine learning techniques were employed to develop models using the training dataset: gradient-boosting machine (GBM), long short-term memory (LSTM), and transformer. The performances of the models were compared using the area under the receiver operating characteristics curve using randomly assigned internal testing dataset. We also validated the developed models using temporal holdout dataset. Pediatric patient surgery cases between November 2020 and January 2021 were used. The performances of the models were compared using the area under the receiver operating characteristic curve (AUROC).

Results

In total, 1,540 (11.73%) patients with intraoperative hypoxemia out of 13,130 patients’ records with 2,367 episodes were included for developing the model dataset. After model development, 200 (13.25%) of the 1,510 patients’ records with 289 episodes were used for holdout validation. Among the models developed, the GBM had the highest AUROC of 0.904 (95% confidence interval [CI] 0.902 to 0.906), which was significantly higher than that of the LSTM (0.843, 95% CI 0.840 to 0.846 P < .001) and the transformer model (0.885, 95% CI, 0.882–0.887, P < .001). In holdout validation, GBM also demonstrated best performance with an AUROC of 0.939 (95% CI 0.936 to 0.941) which was better than LSTM (0.904, 95% CI 0.900 to 0.907, P < .001) and the transformer model (0.929, 95% CI 0.926 to 0.932, P < .001).

Conclusions

Machine learning models can be used to predict upcoming intraoperative hypoxemia in real-time based on the biosignals acquired by patient monitors, which can be useful for clinicians for prediction and proactive treatment of hypoxemia in an intraoperative setting.
Looking beyond the individual–The importance of accessing health and cultural services for Indigenous women in Thunder Bay, Ontario
Authors: Lin Jonathan C. , Toombs Elaine , Sanders Chris , Sinoway Candida , Amirault Marni , Mushquash Christopher J. , Barkman Linda , Deschamps Melissa , Young Meghan , Gauvin Holly , Benoit Anita C.
Published: March 2023

Access to cultural activities and culturally relevant healthcare has always been significant for achieving holistic Indigenous health and continues to be a key factor in shaping the health journey of Indigenous individuals and communities. Previous research has indicated the importance of cultural practices and services in sustaining cultural identity for Indigenous peoples, which is a major influence on their wellbeing. This study marks the first phase in a project aimed at establishing an Indigenous healing program and uses a qualitative research approach to understand the health and cultural services that Indigenous women want and require in Thunder Bay, Ontario. During interviews, participants (n = 22) answered questions around their understandings of health and wellbeing, and how they are able to incorporate cultural practices into their circle of care. Thematic analysis was performed on interview transcripts, and 4 key themes were identified: ‘independence and self-care’, ‘external barriers to accessing services’, ‘finding comfort in the familiar’ and ‘sense of community’. Together these themes illustrate how Indigenous women feel a strong sense of personal responsibility for maintaining their health despite the multiple environmental factors that may act as barriers or supports. Furthermore, the necessity of embedding cultural practices into Indigenous women’s circle of care is highlighted by the participants as they describe the mental, spiritual, social, and emotional health benefits of engaging in cultural activities within their community. The findings demonstrate the need for current modes of care to look beyond the individual and consider the impacts that socio-environmental factors have on Indigenous women. To accomplish this, we hope to increase access to health and cultural services through the creation of an Indigenous healing program that can be adequately incorporated into Indigenous women’s circle of care if they wish to do so.
Architectural archives, a resource for knowledge and collective memory
Authors: Domenichini Riccardo
Published: March 2023

It is difficult to fix coordinates to define architectural archives, related as they are to a discipline that has many declensions and often overlaps with others. Characterized by a multiplicity of types of documentation, from the point of view of production and organization they vary greatly in the range defined by the two poles of personal and corporate archives. Subjected to a strong evolutionary process, marked by the increasingly exclusive presence of digital technology, they constitute a field of continuous learning for archivists and researchers, with the aim of fully exploiting their information potential. Historical research, however, is only one of the fields in which architectural archives can play a primary role. Focusing on the human environment, built and natural, they are vital in the construction and development of collective memory, as much as in the management and protection of the works that make up the common heritage of citizens.
Documento de arquitetura
Authors: Rodrigues Ana Célia , Viana Claudio Muniz
Published: March 2023

Apresenta os processos de identificação arquivística para investigar a gênese do documento de arquitetura como base para organização dos arquivos. A identificação é um método de pesquisa para a Arquivística, de natureza intelectual, que consiste no trabalho de investigação e análise sobre o órgão produtor e seus documentos, que permite normalizar a denominação e o agrupamento das séries documentais para fins de gestão de documentos e de tratamento de documentos acumulados em arquivos. No contexto da identificação, a etapa da identificação de tipologia documental encontra na abordagem da Diplomática, em sua perspectiva clássica e contemporânea, a Tipologia Documental, seus fundamentos teóricos e metodológicos. Nesta perspectiva, apresenta os estudos de identificação desenvolvidos para tratar a tipologia documental do Fundo Severiano Mario Porto custodiado pelo Núcleo de Pesquisa e Documentação da Faculdade de Arquitetura e Urbanismo da Universidade Federal do Rio de Janeiro (NPD/FAU/UFRJ).
Digital Agriculture and Fisheries Policies in the Commonwealth: An Analysis
Authors: Secretariat Commonwealth
Published: March 2023

Within the agricultural and fisheries sectors, digitalisation is seen as a ‘game changer’ for transforming the sectors in low- and middle-income countries, including those across the Commonwealth. For example, digitisation is linked to increased productivity for multiple sectors, including agriculture.

Digitalisation for agriculture and fisheries can be defined to consist of three pillars, namely digital innovations, data infrastructure and business development services, which develop in the context of a broader enabling environments for digitalisation.
Bridging the Human Rights Implementation Gap: A Commonwealth Survey
Authors: Secretariat Commonwealth
Published: March 2023

In January 2022, the Commonwealth Secretariat launched a survey of national frameworks for the implementation of international human rights obligations in Commonwealth member states. The primary objectives of the survey were to:

a. Contribute to the body of knowledge, such as studies conducted by the Office of the United Nations High Commissioner for Human Rights (OHCHR) and other organisations, on the role and effectiveness of National Mechanisms for Implementation, Reporting and Follow-up (NMIRFs). Recent OHCHR studies have shown that NMIRFs are vital for improved implementation and reporting on human rights. They have identified several essential ‘capacities’ for enhanced performance, including engagement, co-ordination, consultation and information management.

b. Map existing national systems for implementation, reporting and follow-up to understand how they implement their mandates, and thereby facilitate an exchange of good practice and lessons learnt.

c. Understand specific needs for further technical assistance for Commonwealth member states to establish and/or strengthen NMIRFs.

d. Provide information to be used in advocacy for formulating common guiding principles on NMIRFs.
Addressing Online Violence Against Women and Girls in the Commonwealth Asia Region: The Role of Bystanders
Authors: Secretariat Commonwealth
Published: March 2023

Online violence is increasing rapidly and is emerging as one of the biggest threats facing the online world today. Acts of online violence take multiple forms, including cyberstalking, cyberbullying, sexual harassment, sex trolling, doxing, hate speech, public shaming and intimidation.

Broadly speaking, online violence against women and girls and the victimisation pattern in Commonwealth Asia member countries are consistent with the overall global trend. However, given unique formal and informal institutions in these countries, perpetration and victimisation related to OVAWG have many significant aspects that are different from most other countries in the world. As a result of underdeveloped regulations and regulatory infrastructure related to OVAWG, it is difficult to arrest, prosecute and convict the perpetrators in most of these countries. Meanwhile, societal norms tend to make victims of OVAWG feel devalued and excluded.
Sekretori Immunoglobulin A Kolostrum Berhubungan dengan Infeksi dan Infeksi Saluran Pernapasan Atas pada Bayi Usia Tiga Tahun: Studi Prospektif
Authors: Priyantini Sri , Purbaningrum Riris , Issanti Laili R , Milla Meidona Nurul
Published: March 2023

Latar belakang. Air susu ibu (ASI) berperan penting dalam sistem kekebalan innate bayi baru lahir. Kolostrum telah diketahui mengandung antibodi terbesar yaitu sIgA yang berasal dari Entero-broncho-Mammary Pathway. Sekretori IgA kolostrum merupakan imunomodulator perkembangan sistem imun bayi baru lahir. Antibodi pada ASI sering dihubungkan dengan perlindungan bayi terhadap infeksi sampai usia 6 bulan. Masih perlu diketahui peranan sIgA kolostrum terhadap kejadian infeksi Balita.Tujuan. Membuktikan hubungan antara kadar sIgA kolostrum dengan frekuensi infeksi umum dan infeksi saluran pernapasan akut (ISPA) pertahun pada Balita. Mengetahui faktor lain yang berhubungan dengan infeksi Balita secara umum.Metode. Studi prospektif pada 53 Balita usia 3 tahun dengan riwayat kehamilan cukup bulan, lahir sehat beserta ibunya. Pengumpulan ASI pada hari ke 2-3 postpartum, sIgA diukur dengan teknik ELISA. Data didapat dari kuesioner dengan kunjungan rumah atau pertelepon. Analisis statistik menggunakan uji Mann-Whitney, chi-square dan Fisher.Hasil. Rerata frekuensi infeksi umum kelompok riwayat kadar sIgA kolostrum rendah (<120mg/dL) lebih sering dibanding kelompok kontrol (5,9 vs 4,2, p=0,03), demikian juga frekuensi ISPA lebih sering dibanding kontrol (5,2 vs 3,8, p=0,041). Terdapat hubungan antara kepadatan hunian dengan sering infeksi, p=0,01.Kesimpulan. Balita dengan riwayat sIgA kolostrum ibu rendah (<120mg/dL) lebih sering mengalami infeksi saluran pernapasan akut dan infeksi secara umum dibanding kontrol. Kepadatan hunian berhubungan dengan riwayat sering infeksi.
Hubungan Intensitas Penggunaan Gawai Sejak Dini dengan Risiko Keterlambatan Perkembangan Bicara dan Bahasa pada Anak Usia 4-5 Tahun
Authors: Septyani Reta Aulia , Lestari Pudji , Suryawan Ahmad
Published: March 2023

Latar belakang. Anak-anak yang menggunakan gawai terlalu sering dan lama dapat menyebabkan anak menjadi malas untuk berinteraksi dengan keluarga maupun teman sebayanya sehingga dapat memengaruhi kontak sosial dan komunikasi. Hal ini dapat menyebabkan perkembangan anak terganggu, khususnya pada aspek bicara dan bahasa.Tujuan. Mengetahui hubungan intensitas penggunaan gawai sejak dini dengan keterlambatan perkembangan aspek bicara dan bahasa pada anak usia 4-5 tahun.Metode. Desain penelitian potong lintang digunakan pada anak usia 4-5 tahun di TK ABA IV dan RA Nurul Hikmah Pamekasan. Penelitian ini dilakukan dengan membandingkan tingkat intensitas penggunaan gawai pada anak dengan hasil skrining perkembangan bicara dan bahasa menggunakan KPSP.Hasil. Sebagian kecil (16,28%) anak menggunakan gawai dengan intensitas rendah, hampir separuh anak menggunakan gawai dengan intensitas sedang sebesar (33,72%) dan separuh lainnya (50%) menggunakan gawai dengan intensitas tinggi. Sebagian besar (66,28%) anak memiliki perkembangan bicara dan bahasa dalam kategori normal, tetapi 29 (33,72%) berisiko keterlambatan perkembangan bicara dan bahasa. Hasil uji Chi-square didapatkan nilai p value = 0,018 (p<0,05). Kesimpulan. Terdapat hubungan antara intensitas penggunaan gawai sejak dini dengan risiko keterlambatan perkembangan bicara dan bahasa pada anak usia 4-5 tahun.
Pengaruh Toksisitas Hematologi Fase Konsolidasi Terhadap Kesintasan Pasien Leukemia Limfoblastik Akut di Rumah Sakit Umum Daerah Dr. Moewardi Surakarta
Authors: Falah Arie , Widiretnani Septin , Umma Husnia Auliyatul
Published: March 2023

Latar belakang. Kemoterapi pada leukemia limfoblastik akut (LLA) memiliki berbagai efek samping. Toksisitas dapat menyebabkan penundaan kemoterapi dan mempengaruhi hasil pengobatan. pada negara maju kesintasan pasien LLA cukup baik namun berbeda di negara berkembang. Tujuan. membuktikan apakah toksisitas kemoterapi hematologi fase konsolidasi mempengaruhi kesintasan pasien LLA anak. Metode. Pasien berusia 1 bulan – 18 tahun yang terdiagnosis LLA dan telah menjalani kemoterapi fase konsolidasi di RSUD Dr. Moewardi Surakarta pada periode bulan Januari 2017 – September 2019 diikutkan dalam penelitian. Data rekam medis tidak lengkap dan pasien down sindrom dieksklusi. Toksisitas kemoterapi hematologi fase konsolidasi dinilai pada setiap subjek berdasarkan kriteria NCI-CTCAE. Kesintasan dan Hazard rasio diperkirakan menggunakan metode Kaplan-Meier dan cox regression. Analisis multivariat regresi cox model interaksi digunakan untuk menganalisa faktor yang paling menentukan kesintasan.Hasil. Sejumlah 46 subjek diikutsertakan dalam penelitian. Toksisitas derajat ringan-sedang (derajat 1-2) sebanyak 34 (73,9%) derajat berat (derajat 3-4) sebanyak 12 (25,6%). Analisis Kaplan Meier menunjukkan tidak terdapat pengaruh antara toksisitas kemoterapi hematologi fase konsolidasi derajat ringan-sedang vs derajat berat dengan kesintasan selama 3 tahun (64% vs 41% p=0,163, HR 1,941, dan IK 0,764-4.934). Melalui analisis multivariat diperoleh derajat toksisitas merupakan faktor prognostik independen yang memengaruhi terhadap kesintasan (p=0,163, HR 1,941) Kesimpulan. Toksisitas kemoterapi hematologi fase konsolidasi tidak memengaruhi kesintasan 3 tahun pada pasien LLA anak.
INDICADORES DE VULNERABILIDADE SOCIOAMBIENTAL E A OCORRÊNCIA DA DENGUE NOS BAIRROS DE COPACABANA, JARDIM BOTÂNICO, GUARATIBA E SANTA CRUZ NA CIDADE DO RIO DE JANEIRO
Authors: Oliveira Raiane Fontes de , Kede Maria Luiza Félix Marques
Published: March 2023

O presente estudo tem por objetivo desenvolver um índice de vulnerabilidade socioambiental a partir de casos confirmados de dengue, considerando a intenção de espacializar e analisar os números de casos de pessoas infectadas conforme o grau de vulnerabilidade socioambiental no município do Rio de Janeiro, no período de 2007 a 2017.  Dessa forma, foram selecionados dois bairros da Zona Sul – Copacabana e Jardim Botânico – e dois bairros da Zona Oeste – Guaratiba e Santa Cruz. Para isto, foram estabelecidas e analisadas variáveis do Censo 2010 (IBGE) por meio da elaboração do Índice de Vulnerabilidade Socioambiental e a confecção de mapas temáticos por setor censitário em ambiente do Sistema de Informação Geográfica. Em seguida, os dados foram analisados pelo método estatístico Análise das Componentes Principais (ACP), com intenção de identificar quais variáveis assumiram maior peso no Índice de Vulnerabilidade Socioambiental. De acordo com os resultados obtidos pela ACP, a infraestrutura e a diferença de renda foram as principais consequências relacionadas ao grau de vulnerabilidade à luz dos casos confirmados de dengue. Em geral, os bairros de Guaratiba e Santa Cruz, localizados na Zona Oeste da cidade do Rio de Janeiro, apresentaram maiores números de casos de pessoas infectadas e apresentaram maior grau de Vulnerabilidade Socioambiental quando comparados aos bairros de Copacabana e Jardim Botânico, localizados na Zona Sul da cidade.
RELAÇÃO ENTRE CONDIÇÃO HÍDRICA E FORMAÇÕES VEGETACIONAIS NATIVAS POR MEIO DE ÍNDICES ESPECTRAIS
Authors: Jesus Janisson Batista de , Souza Bruno Barros de , Gama Dráuzio Correia
Published: March 2023

A coleta de informações biofísicas da vegetação é crucial para analisar as suas características e seu comportamento nos ambientes florestais. Uma das formas de se obter essas informações pode ser realizada utilizando técnicas de sensoriamento remoto, o qual permite analisar espacial e temporalmente os componentes da superfície terrestre, entre eles as diferentes formas de vegetação e as suas características. Sendo assim, o objetivo do estudo foi analisar a condição hídrica de diferentes formações vegetacionais nativas por meio de índices espectrais, visando a identificar quais os Índices de Diferença Normalizada da Água (NDWI) utilizados (MCFEETERS, 1996; GAO, 1996; e ROGERS e KEARNEY, 2004) mais se correlacionam à expressão do Índice de Diferença Normalizada da Vegetação (NDVI) para as épocas chuvosa e seca. Foram obtidas imagens do sensor OLI do satélite Landsat-8 referentes ao período chuvoso e seco em fragmentos de Caatinga densa, aberta e herbácea, Manguezal e Mata Atlântica stricto sensu, extraindo-se o NDVI e correlacionando-o a diferentes equações de NDWI. A equação de McFeeters se destacou como a que apresentou valores mais correlacionados ao NDVI, seguida da de Gao, para as formações vegetacionais estudadas para ambas as épocas pluviométricas, indicando o potencial de uso dessas equações nos estudos dessas vegetações.
O CONTEXTO TERRITORIAL DO SISTEMA CANTAREIRA E A GESTÃO INTEGRADA E PARTICIPATIVA DOS RECURSOS HÍDRICOS
Authors: Chiodi Rafael Eduardo
Published: March 2023

Os Comitês das Bacias Hidrográficas dos Rios Piracicaba, Capivari e Jundiaí (Comitês PCJ) estão entre os mais avançados na implementação do modelo de gestão integrada e participativa dos recursos hídricos. Porém, a transposição das águas da bacia hidrográfica do Rio Piracicaba para a do Alto Tietê pelo Sistema Cantareira, para abastecer a Região Metropolitana de São Paulo, coloca desafios à aplicação desse modelo. O artigo apresenta como o contexto territorial do Sistema Cantareira integra debates e ações que emergem dos Comitês PCJ, demonstra em que medida os atores sociais deste contexto estão presentes em seus espaços públicos e discute tais aspectos com base na noção da gestão integrada e participativa. Para tanto, analisaram-se atas de reuniões, o Plano de Bacia Hidrográfica e informações dos Comitês PCJ. Identificou-se que o Sistema Cantareira é encarado mais como uma obra de engenharia hidráulica, e menos como um contexto que possui múltiplas problemáticas relacionadas aos recursos hídricos. Além de parcos investimentos direcionados a tal contexto, soma-se a inexpressiva representação dos seus atores sociais como membros dos espaços públicos dos Comitês PCJ. Conclui-se que estes aspectos são lacunas à plena gestão integrada e participativa dos recursos hídricos.
MODELOS PALEOCLIMÁTICOS E FORMAS DE RELEVO NO QUATERNÁRIO: IMPLICAÇÕES GEOMORFOLÓGICAS NO SETOR CONTINENTAL DA BAHIA
Authors: Lima Kleber Carvalho , Lupinacci Cenira Maria , Aderaldo Pedro Ítalo Carvalho
Published: March 2023

Em setores específicos da Bahia, modelos paleoclimáticos desenvolvidos nas duas últimas décadas contribuíram para elucidar questões relacionadas às variações nas condições de umidade durante o Quaternário. Da mesma forma, dinâmicas geomorfológicas pretéritas, investigadas em diferentes contextos do estado, corroboraram para o avanço nas discussões sobre a evolução do relevo, apontadas de maneira genérica na literatura clássica. Nesse artigo, objetivou-se avaliar a contribuição de pesquisas desenvolvidas no setor continental baiano, no sentido de compreender a morfogênese regional quaternária, no contexto dos grandes compartimentos do relevo. A sistematização e espacialização dos proxies utilizados em literaturas anteriores contribuíram para a identificação de três períodos conhecidos na escala do Quaternário, que demonstraram a relação entre períodos úmidos/secos e as respostas do relevo às diferentes condições de umidade. Da mesma forma, quatro gaps temporais foram identificados, os quais necessitam de futuras investigações que visem a complementar as informações sobre o setor pesquisado.
POTENCIAL EROSIVO DA BACIA HIDROGRÁFICA DO RIO JABOATÃO - PE
Authors: Oliveira Izabelly Victoria Alves de , Souza Deivid Damião Roque de , Barbosa Neto Manuella Vieira , Miranda Marcelo Ricardo Bezerra de
Published: March 2023

O processo erosivo é um dos mais danosos causadores de degradação ambiental. Um diagnóstico do potencial erosivo de uma região pode auxiliar no entendimento dos mecanismos que atuam nas áreas naturais e antropizadas, tornando possível a orientação das atividades a serem desenvolvidas. Desse modo, o objetivo do presente estudo foi analisar os riscos decorrentes da suscetibilidade natural à erosão da bacia hidrográfica do rio Jaboatão-PE. Para isso, utilizou-se a metodologia de mapeamento e análise da suscetibilidade natural à perda de solo que se baseia nos conceitos de estabilidade e instabilidade ambiental. Realizou-se uma avaliação do balanço existente entre os processos de morfogênese/pedogênese por meio dos atributos da paisagem: pedologia, geologia, declividade, cobertura vegetal e intensidade pluviométrica, com a utilização de ferramentas de geoprocessamento. Por fim, realizaram-se trabalhos de campo para análise dos riscos decorrentes dos processos erosivos presentes na bacia. Foi possível verificar que em 70% da área predomina a classe de erosão medianamente estável/suscetível, e a bacia apresenta uma quantidade significativa de locais com construções em áreas propícias a movimentos gravitacionais de massa, com alto grau natural de suscetibilidade, demonstrando, assim, a necessidade de medidas conservacionistas para a diminuição dos riscos.
Nachhaltige Stadtentwicklung: Transformationspfade und Gestaltungsmerkmale
Authors: Tappeser Valentin , Dehnhardt Alexandra
Published: March 2023

Einführung in das Schwerpunktthema
Die Doppelwirkung von Information für klimafreundliches Handeln
Authors: Frick Marc , Foese Dario , Von Graevenitz Kathrine , Kesternich Martin , Wagner Ulrich
Published: March 2023

Informationen sind für eine erfolgreiche Klimapolitik in doppelter Hinsicht wichtig: Sie werden benötigt, wenn Potenziale zur Vermeidung von Emissionen identifiziert und klimapolitische Instrumente ausgewählt werden. Und sie sind zentral, damit Bürger/innen selbst Entscheidungen im Sinne des Klimaschutzes treffen können.
Effect of the Amount of Carbon in the Fe3O4@ZnO-C Nanocomposites on Its Structure and Magnetic Properties
Authors: Astuti Astuti , Arief Syukri , Pebrina Devi
Published: March 2023

Synthesis and characterization of structure magnetic properties of Fe3O4@ZnO- C nanocomposite have been done through the precipitation method. This study aimed to discover the effect of concentrations/thickness of carbon layer on crystal structure and magnetic properties of Fe3O4@ZnO-C nanocomposites. Fe3O4 and Fe3O4@ZnO were the samples used in the study, and variations in the amount of carbon were 0.2, 0.1, and 0.05 g. Nanocomposites were characterized using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and vibrating sample magnetometer (VSM). Based on the results of XRD, it has been found that the crystal structure for Fe3O4 was cubic, while ZnO was hexagonal wurtzite. The addition of carbons to Fe3O4@ZnO caused a broadening of the diffraction peaks and a decrease in the degree of crystallinity. The bonds formed on Fe3O4@ZnO-C nanocomposites, i.e. Fe-O bonds indicated the formation of Fe3O4, Zn-O bonds showed the formation of ZnO and C-O, C-H, and O-H bonds revealed the presence of a carbon layer originated from glucose. The VSM results showed that the magnetic saturation decreased with increasing carbon mass. Overall, the carbon-coated nanocomposite material with a carbon mass variation of 0.2, 0.1, and 0.05 g showed superparamagnetic properties with a magnetic saturation of 18.23 emu/g, 19.33 emu/g and 22.05 emu/g, while for the coercive field of 92.29 Oe, 92.90 Oe and 89.60 Oe, respectively. Based on these characterization results, Fe3O4@ZnO-C nanocomposite materials can potentially be developed as biomedical materials, such as the materials for photothermal therapy for cancer cells.
Optimization and characterization of biodegradable film based on glutinous flour/glycerol/chitosan/ZnO using Response Surface Methodology (RSM) - Central Composite Design (CCD)
Authors: Safira Aulia Beta , Purbasari Aprilina
Published: March 2023

Starch-based films are considered more competitive than petroleum because they are renewable, environmentally friendly, and easily degraded. The film in this study was fabricated from white glutinous flour, glycerol, chitosan, and ZnO through a starch gelatinization process. Chitosan content ranges from 2-4% (w/v), ZnO 4-8% of the dry weight of solid, and glycerol 15-45% of the dry weight of solids with a mass of white glutinous flour as much as 3 g was determined. Optimization and determination of running variables based on Central Composite Design. Response variables such as tensile strength, elongation, and water absorption were observed as important parameters in applying film as packaging materials. The Design Expert program recommended 2 g of chitosan: 8 % ZnO: 36.02% glycerol as the best composition in film fabrication, which aims to obtain maximum tensile strength and elongation, as well as minimum water absorption with the maximum desirability value (0.660). The predicted response values under optimal conditions by RSM were 3.68 MPa for tensile strength, 86.79% for elongation, and 268.09% for water absorption. The actual response has a tensile strength of 3.31 MPa, elongation of 83.5%, and water absorption of 320%. On average, a white glutinous flour/glycerol/chitosan/ZnO-based film required ± 45 days to degrade in the soil completely.
Determination of membrane protein orientation upon liposomal reconstitution down to the single vesicle level
Authors: Veit Sarina , Paweletz Laura Charlotte , Günther Pomorski Thomas
Published: March 2023

Reconstitution of membrane proteins into liposomal membranes represents a key technique in enabling functional analysis under well-defined conditions. In this review, we provide a brief introduction to selected methods that have been developed to determine membrane protein orientation after reconstitution in liposomes, including approaches based on proteolytic digestion with proteases, site-specific labeling, fluorescence quenching and activity assays. In addition, we briefly highlight new strategies based on single vesicle analysis to address the problem of sample heterogeneity.
LINC00511 promotes melanoma progression by targeting miR-610/NUCB2
Authors: Zhang Guangjing , Wang Zhengxiang , Liu Jie , Feng Shijun , Ji Shanshan , Ai Dongfang
Published: March 2023

Long intergenic noncoding RNA 00511 (LINC00511) predicts poor prognosis in various malignancies and functions as an oncogene in distinct malignant tumors. The role of LINC00511 in melanoma progression was assessed. In our research, expression of LINC00511 in melanoma cells was detected by quantitative reverse transcription PCR. Colony formation and CCK8 assays were used to detect cell proliferation. Cell metastasis was evaluated by transwell and wound healing assays. Downstream target of LINC00511 was investigated by luciferase activity assay. As a results, LINC00511 was elevated in melanoma cells and tissues. Loss of LINC00511 decreased cell viability, reduced proliferation, invasion, and migration of melanoma. miR-610 was target of LINC00511, and miR-610 binds to 3′UTR of nucleobindin-2 (NUCB2). Inhibition of miR-610 attenuated LINC00511 deficiency-induced decrease of NUCB2 in melanoma cells. Loss of miR-610 weakened LINC00511 deficiency-induced decrease of cell viability, proliferation, invasion, and migration of melanoma. In conclusion, silence of LINC00511 reduced cell proliferation and metastasis of melanoma through down-regulation of miR-610-mediated NUCB2.
The effect of heterophilic antibody interference in thyroglobulin measurement on different immunoassay devices
Authors: Kutluay Ismet Gamze , Bozdayi Mehmet Akif , Ulusal Hasan , Tarakcioglu Mehmet
Published: March 2023

Objectives

Serum thyroglobulin (Tg) is a biochemical marker used in the follow-up of patients with differentiated thyroid cancer (DTC), but heterophile antibody interference may limit the clinical use of Tg.

Case presentation

In the first-year follow-up of a 31-year-old female patient who received treatment for papillary thyroid CA, a clinically significant difference was found in the Tg values measured by two different brand devices with similar measurement methods.

Conclusions

Despite the use of state-of-the-art laboratory equipment, heterophile antibodies in immunoassay analysis can still cause false high Tg measurements. Our case report shows that analytical errors can be avoided with attention and effective communication between clinicians and laboratory specialists. In this way, patients will be prevented from being misdiagnosed and/or exposed to treatment.
Multifamily therapy for young people with OCD: An acceptability and satisfaction study
Authors: Kindynis Zoë , Espie Jonathan , Volz Chloë , Jassi Amita
Published: March 2023

Individual cognitive-behavioral therapy (CBT) is the recommended first-line psychological treatment for young people with obsessive-compulsive disorder (OCD), with good outcomes. However, because some young people only partially respond to CBT, it is necessary to improve treatment outcomes. This is the first study to explore the acceptability and satisfaction of a new multifamily therapy (MFT). Three groups were attended by 16 young people with OCD, their parents, and siblings. Parents and young people completed questionnaires and focus groups. Thematic analysis was applied to transcripts of focus groups. The majority of young people and parents (93.9%) were satisfied or very satisfied. Thematic analysis identified benefits, including increased understanding of OCD, support from the group, and a feeling of not being alone. Further research is required to establish the group's effectiveness on OCD symptom severity and to identify the factors that MFT addresses. MFT shows promise as an acceptable and satisfactory treatment.
If it's offered, will they come? Practical considerations when offering intensive PTSD treatment in an outpatient Veterans Affairs PTSD clinic
Authors: Sciarrino Nicole A. , Myers Ursula S.
Published: March 2023

Evidence-based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD) are efficacious; however, treatment dropout remains high. The delivery of intensive EBPs for PTSD (i.e., sessions three times per week or more) and telemental health may address barriers impacting dropout. Current evidence for intensive EBPs comes primarily from programs specifically designed for this level of care. Therefore, the feasibility of delivering intensive EBPs for PTSD in traditional outpatient clinics remains unclear. The aim of this pilot study was to identify veteran level of interest in intensive treatment and explore the feasibility of delivering intensive treatment via telemental health in an outpatient PTSD clinic at a Veterans Affairs (VA) hospital. One provider offered intensive treatment to 14 veterans. Three of the veterans initiated intensive treatment and completed with benefit. Veteranand system-level barriers, as well as veteran preferences for initiating intensive therapy and suggestions for implementing intensive EBPs in a routine outpatient clinic, are discussed.
An Accident With the Death Drive and Its Working Through in the Analyst's Countertransference
Authors: Roth Merav
Published: March 2023

Working through the different faces and vicissitudes of the death drive in the countertransference, and especially through projective identification, is a very challenging process. A thorough and versatile process of containment and working through of the manifold threatening expressions and influences of the death drive is required, experienced most specifically and deeply in the arena of projective identification. This paper demonstrates how each aspect that unfolds in the analyst's countertransference sheds light on a particular layer of anxiety and internal object relations related to it. The creation of a new meaning to the differing expressions of the death drive gradually lessens the compulsion to repeat and enables a better integration between the life and death drives. This process will be illustrated by a prolonged clinical case that involved intense internal working through of the death drive in the analyst's countertransference.
Perspectivas de los mecanismos de control y seguimiento en las cooperativas colombianas con relación a las cooperativas internacionales
Authors: Quitian Ariza Víctor Alfonso
Published: March 2023

La finalidad de este artículo, es presentar los resultados que surgieron de una revisión bibliográfica descriptiva, con el fin de verificar los aspectos normativos de las Cooperativas a nivel de Latinoamérica, de igual manera comparar los mecanismos de control y seguimiento de las Cooperativas Colombianas con relación a los de las Cooperativas a nivel Internacional. Para tal fin, se establecieron y desarrollaron 8 categorías nombradas así: Concepto de control interno en las Cooperativas, los objetivos del control interno en las cooperativas, componentes del control interno, resultados e impactos, la integración con la estrategia organizacional, los beneficios, limitaciones, fallas y la Gestión del cumplimiento.
Caso de Estudio de medición del nivel de implementación del componente de salud mental a partir del decreto 1072 de 2015
Authors: Cardona alzate Daniela , Naranjo Herrera Cristhian Guillermo
Published: March 2023

El objetivo del presente artículo es dar a conocer los resultados obtenidos al medir el nivel de implementación del componente de la salud mental en una empresa del sector energético en Manizales, Colombia, según lo dispuesto por el decreto 1072 de 2015. El estudio realizado es de tipo cuantitativo con el método de estudio de caso descriptivo y la utilización de técnicas de revisión documental y visitas de campo. Para la recolección de información se realizaron visitas a la empresa, reuniones con el responsable del sistema de seguridad y salud en el trabajo y revisión detallada de documentos, registros e informes internos apoyada en una ficha de observación.
Los resultados muestran que, en su gran mayoría, las decisiones y actuaciones de la empresa son coherentes con las actividades, deberes, obligaciones y responsabilidades que la citada norma le exige. Por tanto, se concluye que desde los requerimientos estipulados por la normativa legal del sistema de gestión de seguridad y salud en el trabajo (SGSST), la empresa presenta un elevado cumplimiento en cada una de sus fases (planear, hacer, verificar y actuar). No obstante, dado que la normativa mencionada con frecuencia se refiere a la salud en general y no de forma específica a la salud mental, se recomienda a la empresa hacer explícito y detallar la misma en toda la operación del sistema.
Negocios y data, una bina poderosa en la era digital. Recomendaciones para las mipymes en la Orinoquia
Authors: Balcázar Velásquez Jorge Daniel
Published: March 2023

El artículo busca entender en qué consiste la inteligencia de negocios y el big data, y comprender cómo aplicar estos conceptos y herramientas a la propuesta de valor de de ls mipymes en la Orinoquía, que dé como resultado la creación de una ventaja competitiva en un entorno globalizado.