bluuebunny/crossref_metadata_2025 huggingface dataset:
CT Texture Analysis of Pulmonary Neuroendocrine Tumors—Associations with Tumor Grading and Proliferation
Authors: Meyer Hans-Jonas , Leonhardi Jakob , Höhn Anne Kathrin , Pappisch Johanna , Wirtz Hubert , Denecke Timm , Frille Armin
Published: December 2021

Texture analysis derived from computed tomography (CT) might be able to provide clinically relevant imaging biomarkers and might be associated with histopathological features in tumors. The present study sought to elucidate the possible associations between texture features derived from CT images with proliferation index Ki-67 and grading in pulmonary neuroendocrine tumors. Overall, 38 patients (n = 22 females, 58%) with a mean age of 60.8 ± 15.2 years were included into this retrospective study. The texture analysis was performed using the free available Mazda software. All tumors were histopathologically confirmed. In discrimination analysis, “S(1,1)SumEntrp” was significantly different between typical and atypical carcinoids (mean 1.74 ± 0.11 versus 1.79 ± 0.14, p = 0.007). The correlation analysis revealed a moderate positive association between Ki-67 index with the first order parameter kurtosis (r = 0.66, p = 0.001). Several other texture features were associated with the Ki-67 index, the highest correlation coefficient showed “S(4,4)InvDfMom” (r = 0.59, p = 0.004). Several texture features derived from CT were associated with the proliferation index Ki-67 and might therefore be a valuable novel biomarker in pulmonary neuroendocrine tumors. “Sumentrp” might be a promising parameter to aid in the discrimination between typical and atypical carcinoids.
Dual Disorders in the Consultation Liaison Addiction Service: Gender Perspective and Quality of Life
Authors: Ferrer-Farré Teresa , Dinamarca Fernando , Mestre-Pintó Joan Ignasi , Fonseca Francina , Torrens Marta
Published: December 2021

Dual disorders (DD) and gender differences comprise an area of considerable concern in patients with substance use disorder (SUD). This study aims to describe the presence of DD among patients with SUD admitted to a general hospital and attended by a consultation liaison addiction service (CLAS), in addition to assessing its association with addiction severity and quality of life from a gender perspective, between 1 January and 30 September 2020. The dual diagnosis screening interview (DDSI), the severity of dependence scale (SDS), and the WHO well-being index were used to evaluate the patients. In the overall sample, DD prevalence was 36.8%, (women: 53.8% vs. men: 32.7%, NS). In both genders the most prevalent DD was depression (33.8%, women: 46.2% vs. men: 30.9%, p = 0.296). Women presented more panic disorders (46.2% vs. 12.7%, p = 0.019) and generalized anxiety (38.5% vs. 10.9%, p = 0.049) than men. When DD was present, women had worse quality of life than men (21.7 vs. 50 points, p = 0.02). During lockdown period 77 patients were attended to and 13 had COVID-19 infection, with no differences in relation to sociodemographic and consumption history variables. The study confirms a high prevalence of DD among patients with SUD admitted to a general hospital for any pathology, and its being associated with worse quality of life, particularly in women.
Similar Adaptations to 10 Weeks Concurrent Training on Metabolic Markers and Physical Performance in Young, Adult, and Older Adult Women
Authors: Andrade David C. , Flores-Opazo Marcelo , Peñailillo Luis , Delgado-Floody Pedro , Cano-Montoya Johnattan , Vásquez-Gómez Jaime A. , Alvarez Cristian
Published: December 2021

It has been proposed that the combination of high-intensity aerobic exercises and resistance training (RT) known as concurrent training (CT) could improve metabolic syndrome (MetS) markers, and that the exercise mixture in CT could dampen muscle anaerobic pathways, a result known as the interference effect. However, there is scarce evidence on its effects in women across different ages. Therefore, we sought to determine the effects of a 10-week CT intervention on MetS markers and endurance performance in adult women and compared age-related differences between young, adult, and older participants. A total of 112 women with >1 MetS risk factors were included in the study. Participants were allocated to different groups according to the following cutoff age ranges: 20–29years (y), n = 25; 30–39y, n = 35; 40–49y, n = 43; and 50–59y, n = 53. Participants performed 10 weeks of CT, including resistance training (RT), involving six major muscle groups, and high-intensity interval training (HIIT) in a cycle ergometer. Anthropometric, cardiovascular, metabolic, and performance outcomes were assessed before and after the intervention. The CT induced significant improvements in waist circumference (WC) (20–29y: –2.5; 30–39y: –4.1; 40–49y: –4.2; 50–59y: –2.8 Δcm) and the distance achieved in the six-minute walking test (6Mwt) (20–29y: +47.6; 30–39y: +66.0; 40–49y: +43.0; 50–59y: +58.6 Δm) across all age groups, without significant differences between groups. In addition, a significant correlation was found between 6Mwt and WC, independent of age. In conclusion, our results showed that a 10-week CT intervention improved MetS risk factors in women, suggesting that the beneficial effects promoted by CT are independent of age and confirming CT as an effective, age-independent training regimen to improve metabolic health in women.
Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity
Authors: Maloberti Alessandro , Ughi Nicola , Bernasconi Davide Paolo , Rebora Paola , Cartella Iside , Grasso Enzo , Lenoci Deborah , Del Gaudio Francesca , Algeri Michela , Scarpellini Sara , Perna Enrico , Verde Alessandro , Santolamazza Caterina , Vicari Francesco , Frigerio Maria , Alberti Antonia , Valsecchi Maria Grazia , Rossetti Claudio , Epis Oscar Massimiliano , Giannattasio Cristina ,   on the behalf of the Niguarda COVID-19 Working Group
Published: December 2021

The most common arrhythmia associated with COronaVIrus-related Disease (COVID) infection is sinus tachycardia. It is not known if high Heart Rate (HR) in COVID is simply a marker of higher systemic response to sepsis or if its persistence could be related to a long-term autonomic dysfunction. The aim of our work is to assess the prevalence of elevated HR at discharge in patients hospitalized for COVID-19 and to evaluate the variables associated with it. We enrolled 697 cases of SARS-CoV2 infection admitted in our hospital after February 21 and discharged within 23 July 2020. We collected data on clinical history, vital signs, laboratory tests and pharmacological treatment. Severe disease was defined as the need for Intensive Care Unit (ICU) admission and/or mechanical ventilation. Median age was 59 years (first-third quartile 49, 74), and male was the prevalent gender (60.1%). 84.6% of the subjects showed a SARS-CoV-2 related pneumonia, and 13.2% resulted in a severe disease. Mean HR at admission was 90 ± 18 bpm with a mean decrease of 10 bpm to discharge. Only 5.5% of subjects presented HR > 100 bpm at discharge. Significant predictors of discharge HR at multiple linear model were admission HR (mean increase = β = 0.17 per bpm, 95% CI 0.11; 0.22, p < 0.001), haemoglobin (β = −0.64 per g/dL, 95% CI −1.19; −0.09, p = 0.023) and severe disease (β = 8.42, 95% CI 5.39; 11.45, p < 0.001). High HR at discharge in COVID-19 patients is not such a frequent consequence, but when it occurs it seems strongly related to a severe course of the disease.
Comparison of Various Indices in Identifying Insulin Resistance and Diabetes in Chronic Spinal Cord Injury
Authors: Farkas Gary J. , Gordon Phillip S. , Trewick Nareka , Gorgey Ashraf S. , Dolbow David R. , Tiozzo Eduard , Berg Arthur S. , Gater David R.
Published: December 2021

The purpose of this screening and diagnostic study was to examine the accord among indices of glucose metabolism, including the Homeostatic Model Assessment for Insulin Resistance (HOMA), HOMA2, Matsuda Index, Quantitative Insulin-sensitivity Check Index (QUICKI), hemoglobin A1C (HbA1C), and fasting plasma glucose (FPG) against intravenous glucose tolerance test-measured insulin sensitivity (Si) in individuals with chronic motor complete SCI. Persons with chronic (≥12-months post-injury) SCI (n = 29; 79% men; age 42.2 ± 11.4; body mass index 28.6 ± 6.4 kg/m2; C4-T10) were included. Measures were compared using adjusted R2 from linear regression models with Akaike information criterion (AIC, a measure of error). QUICKI had the greatest agreement with Si (adjusted R2 = 0.463, AIC = 91.1, p = 0.0001), followed by HOMA (adjusted R2 = 0.378, AIC = 95.4, p = 0.0008), HOMA2 (adjusted R2 = 0.256, AIC = 99.7, p = 0.0030), and the Matsuda Index (adjusted R2 = 0.356, AIC = 95.5, p = 0.0004). FPG (adjusted R2 = 0.056, AIC = 107.5, p = 0.1799) and HbA1C (adjusted R2 = 0.1, AIC = 106.1, p = 0.0975) had poor agreement with Si. While HbA1C and FPG are commonly used for evaluating disorders of glucose metabolism, QUICKI demonstrates the best accord with Si compared to the other measures.
One Year Assessment of the Hearing Preservation Potential of the EVO Electrode Array
Authors: Guevara Nicolas , Parietti-Winkler Cécile , Godey Benoit , Franco-Vidal Valerie , Gnansia Dan , Ardoint Marine , Hoen Michel , Karoui Chadlia , Truy Eric , Vincent Christophe , Mosnier Isabelle , Nguyen Yann
Published: December 2021

Background: A prospective longitudinal multicentre study was conducted to assess the one-year postsurgical hearing preservation profile of the EVOTM electrode array. Methods: Fifteen adults presenting indications of electro-acoustic stimulation (pure-tone audiometry (PTA) thresholds ≤70 dB below 750 Hz) were implanted with the EVO™ electrode array. Hearing thresholds were collected at five time-points from CI activation to twelve months (12M) after activation. Hearing thresholds and hearing preservation profiles (HEARRING group classification) were assessed. Results: All subjects had measurable hearing thresholds at follow-up. No case of complete loss of hearing or minimal hearing preservation was reported at any time point. At activation (Nact = 15), five participants had complete hearing preservation, and ten participants had partial hearing preservation. At the 12M time point (N12m = 6), three participants had complete hearing preservation, and three participants had partial hearing preservation. Mean hearing loss at activation was 11 dB for full range PTA and 25 dB for PTAs low-frequency (125–500 Hz). Conclusions: This study provides the first longitudinal follow-up on associated hearing profiles to the EVO™ electrode array, which are comparable to the literature. However, other studies on larger populations should be performed.
Effectiveness of Psychological Treatments for Borderline Personality Disorder and Predictors of Treatment Outcomes: A Multivariate Multilevel Meta-Analysis of Data from All Design Types
Authors: Rameckers Sophie A. , Verhoef Rogier E. J. , Grasman Raoul P. P. P. , Cox Wouter R. , van Emmerik Arnold A. P. , Engelmoer Izabella M. , Arntz Arnoud
Published: December 2021

We examined the effectiveness of psychotherapies for adult Borderline Personality Disorder (BPD) in a multilevel meta-analysis, including all trial types (PROSPERO ID: CRD42020111351). We tested several predictors, including trial- and outcome type (continuous or dichotomous), setting, BPD symptom domain and mean age. We included 87 studies (N = 5881) from searches between 2013 and 2019 in four databases. We controlled for differing treatment lengths and a logarithmic relationship between treatment duration and effectiveness. Sensitivity analyses were conducted by excluding outliers and by prioritizing total scale scores when both subscale and total scores were reported. Schema Therapy, Mentalization-Based Treatment and reduced Dialectical Behavior Therapy were associated with higher effect sizes than average, and treatment-as-usual with lower effect sizes. General severity and affective instability showed the strongest improvement, dissociation, anger, impulsivity and suicidality/self-injury the least. Treatment effectiveness decreased as the age of participants increased. Dichotomous outcomes were associated to larger effects, and analyses based on last observation carried forward to smaller effects. Compared to the average, the highest reductions were found for certain specialized psychotherapies. All BPD domains improved, though not equally. These findings have a high generalizability. However, causal conclusions cannot be drawn, although the design type did not influence the results.
The Impact of COVID-19 Pandemic and Lockdown Restrictions on Cardiac Implantable Device Recipients with Remote Monitoring
Authors: Diemberger Igor , Vicentini Alessandro , Cattafi Giuseppe , Ziacchi Matteo , Iacopino Saverio , Morani Giovanni , Pisanò Ennio , Molon Giulio , Giovannini Tiziana , Dello Russo Antonio Dello , Boriani Giuseppe , Bertaglia Emanuele , Biffi Mauro , Bongiorni Maria Grazia , Rordorf Roberto , Zucchelli Giulio
Published: December 2021

From 2020, many countries have adopted several restrictions to limit the COVID-19 pandemic. The forced containment impacted on healthcare organizations and the everyday life of patients with heart disease. We prospectively analyzed data recorded from implantable defibrillators and/or cardiac resynchronization devices of Italian patients during the lockdown (LDP), post-lockdown period (PLDP) and a control period (CP) of the previous year. We analyzed device data of the period 9 March 2019–31 May 2020 of remotely monitored patients from 34 Italian centers. Patients were also categorized according to areas with high/low infection prevalence. Among 696 patients, we observed a significant drop in median activity in LDP as compared to CP that significantly increased in the PLDP, but well below CP (all p < 0.0001). The median day heart rate and heart rate variability showed a similar trend. This behavior was associated during LDP with a significant increase in the burden of atrial arrhythmias (p = 0.0150 versus CP) and of ventricular arrhythmias [6.6 vs. 1.5 per 100 patient-weeks in CP; p = 0.0026]; the latter decreased in PLDP [0.3 per 100 patient-weeks; p = 0.0035 vs. LDP]. No modifications were recorded in thoracic fluid levels. The high/low prevalence of COVID-19 infection had no significant impact. We found an increase in the arrhythmic burden in LDP coupled with a decrease in physical activity and heart rate variability, without significant modifications of transthoracic impedance, independent from COVID-19 infection prevalence. These findings suggest a negative impact of the COVID-19 pandemic, probably related to lockdown restrictions.
Virtual Surgical Planning: Modeling from the Present to the Future
Authors: Singh G. Dave , Singh Manarshhjot
Published: December 2021

Virtual surgery planning is a non-invasive procedure, which uses digital clinical data for diagnostic, procedure selection and treatment planning purposes, including the forecast of potential outcomes. The technique begins with 3D data acquisition, using various methods, which may or may not utilize ionizing radiation, such as 3D stereophotogrammetry, 3D cone-beam CT scans, etc. Regardless of the imaging technique selected, landmark selection, whether it is manual or automated, is the key to transforming clinical data into objects that can be interrogated in virtual space. As a prerequisite, the data require alignment and correspondence such that pre- and post-operative configurations can be compared in real and statistical shape space. In addition, these data permit predictive modeling, using either model-based, data-based or hybrid modeling. These approaches provide perspectives for the development of customized surgical procedures and medical devices with accuracy, precision and intelligence. Therefore, this review briefly summarizes the current state of virtual surgery planning.
Implementation of the Treat-to-Target Concept in Evaluation of Psoriatic Arthritis Patients
Authors: Gazitt Tal , Elhija Muhanad Abu , Haddad Amir , Lavi Idit , Elias Muna , Zisman Devy
Published: December 2021

Background: The treat-to-target approach was recently adopted for psoriatic arthritis (PsA) management. Objective: To assess the implementation of the “treat-to-target” (T2T) concept in daily management of PsA by use of composite scores of disease activity versus clinical judgement alone. Methods: A total of 117 PsA patients from a longitudinal PsA cohort were enrolled consecutively in the study during each patient’s first clinic visit during 2016–2017. Clinic notes from the treating rheumatologist were reviewed by an independent rheumatologist, noting clinical impression of disease activity, treatment changes based on clinical judgement, and rationale. Treatment changes were then compared to the use of formal disease activity parameters in Minimal Disease Activity (MDA) and Disease Activity Index for Psoriatic Arthritis (DAPSA) composite measures. All associations were assessed using the chi-square test or the Mann–Whitney test, as appropriate. Results: The 117 PsA patient cohort consisted of 65.5% women, mean age 58.4 ± 13.6 years. Clinical judgement of treating rheumatologist concorded with MDA and DAPSA in 76 (65.5%) and 74 (64.9%) patients, respectively. Agreement between clinical judgement and composite measure criteria did not correlate with patient age, sex, alcohol/tobacco use, or treatment regimens chosen. Disagreement between physician assessment and MDA occurred in 40 (34.5%) cases: in 30 cases, the MDA status was overestimated due to disregard of patient reported outcomes (PRO), while underestimation of MDA status occurred in 25% of cases with treatment changes made in patients with a single active joint or enthesis. Underestimation of disease activity using DAPSA occurred in 22 cases and could be attributed to disregarding tender joint count, patient pain visual analogue scale and C-reactive protein level. Conclusion: In our cohort, agreement between clinical impression and formal composite measure utilization for implementation of T2T strategy occurred in 65% of patients. Discordance resulted from physicians’ overlooking PRO and emphasizing objective findings when using clinical judgement alone.
Comparison of Outcomes between Minimally Invasive Lateral Approach Vertebral Reconstruction Using a Rectangular Footplate Cage and Conventional Procedure Using a Cylindrical Footplate Cage for Osteoporotic Vertebral Fracture
Authors: Segi Naoki , Nakashima Hiroaki , Kanemura Tokumi , Satake Kotaro , Ito Kenyu , Tsushima Mikito , Tanaka Satoshi , Ando Kei , Machino Masaaki , Ito Sadayuki , Yamaguchi Hidetoshi , Koshimizu Hiroyuki , Tomita Hiroyuki , Ouchida Jun , Morita Yoshinori , Imagama Shiro
Published: December 2021

The aim of the current study was to compare outcomes between lateral access vertebral reconstruction (LAVR) using a rectangular footplate cage and the conventional procedure using a cylindrical footplate cage in patients with osteoporotic vertebral fracture (OVF). We included 46 patients who underwent anterior–posterior combined surgery for OVF: 24 patients underwent LAVR (Group L) and 22 underwent the conventional procedure (Group C). Preoperative, postoperative, and 1- and 2-year follow-up X-ray images were used to measure local lordotic angle, correction loss, and cage subsidence (>2 mm in vertebral endplate depression). In anterior surgery, the operation time was significantly shorter (183 vs. 248 min, p < 0.001) and the blood loss was significantly less (148 vs. 406 mL, p = 0.01) in Group L than in Group C. In Group C, two patients had anterior instrumentation failure. Correction loss was significantly smaller in Group L than in Group C (1.9° vs. 4.9° at 1 year, p = 0.02; 2.5° vs. 6.5° at 2 years, p = 0.04, respectively). Cage subsidence was significantly less in Group L than in Group C (29% vs. 80%, p < 0.001). LAVR using a rectangular footplate cage is an effective treatment for OVF to minimize surgical invasiveness and postoperative correction loss.
Association of Interstitial Cystitis/Bladder Pain Syndrome with Stress-Related Diseases: A Nationwide Population-Based Study
Authors: Yang Min-Hsin , Huang Jing-Yang , Chen Sung-Lang , Wei James Cheng-Chung
Published: December 2021

Background: Stress-related diseases (SRDs) are adjustment disorders triggered by stressful life changes. There is a growing body of evidence showing that stress plays an important role in the pathophysiology of IC/BPS. In the present study, we investigated the association between SRDs and a subsequent association of interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: We performed a nested case-control study from the Longitudinal Health Insurance Database (LHID) of Taiwan. The two-year time-varying association between SRDs and IC/BPS was explored to distinguish the short- or long-term effects of these factors. We then conducted multiple conditional logistic regressions to evaluate the adjusted odds ratio (OR) of IC/BPS in patients with a history of SRDs. Results: A total of 1103 IC/BPS patients and 4412 non-IC/BPS patients were analyzed. For all SRDs, the significantly increased risks were obtained in 2 years before IC/BPS diagnosis, and the higher OR was observed within 3 months before the diagnosis of IC/BPS. Multiple conditional logistic regressions showed that patients who had prior medical care for urinary tract infection (OR = 10.95, 95% CI = 9.07 to 13.22), chronic obstructive pulmonary disease (OR = 1.48, 95% CI = 1.13 to 1.93), peptic ulcer (OR = 1.69, 95% CI = 1.37 to 2.09), inflammatory bowel syndrome (OR = 1.66, 95% CI = 1.21 to 2.29), autoimmune diseases (OR = 1.48, 95% CI = 1.11 to 1.97), depression (OR = 1.54, 95% CI = 1.24 to 1.91), sleep disorders (OR = 1.45, 95% CI = 1.19 to 1.78), and allergic rhinitis (OR = 1.29, 95% CI = 1.03 to 1.62) within 2 years had a significant risk of IC/BPS. Conclusions: Our study demonstrates that the health care for SRDs within the previous 2 years is associated with an increased risk of subsequent IC/BPS. The time-varying association provides an important insight that helps us to identify cases with IC/BPS, especially among patients with repeated UTI visits.
An Evaluation of a Simplified Impression Membrane Sampling Method for the Diagnosis of Microbial Keratitis
Authors: Somerville Tobi F. , Herbert Rose , Neal Timothy , Horsburgh Malcolm , Kaye Stephen B.
Published: December 2021

The purpose of this study was to compare bacterial isolation rate using a corneal impression membrane (CIM) and a sharp instrument for obtaining corneal samples from patients with suspected microbial keratitis (MK). Data was retrospectively collected for all patients that had corneal samples taken for presumed MK between May 2014 and May 2020. Prior to May 2017 samples were collected by scraping the edges of the ulcer with a blade. From May 2017, samples were collected by placing a CIM (Millicell cell culture insert) against the ulcer. All corneal samples were processed using the same conventional diagnostic culture method. A total of 3099 corneal samples were included, of which 1214 (39.2%) were corneal scrapes and 1885 (60.9%) CIMs. Microorganisms were isolated from 235 (19.4%) and 1229 (65.2%) cases using a corneal scrape and CIM, respectively (p < 0.001). Of routinely described pathogenic microorganisms, there were significant increases in the isolations of S. aureus (2.4% to 11.3%) and Serratia (0.5% to 1.7%) using the CIM and no significant changes in the isolations of S. pneumoniae and P. aeruginosa. No significant differences were seen between the isolation rates of fungi or Acanthamoeba species. There was a significant increase in the isolation rates of other Streptococcal species (0.7% to 6.9%) and CNS species, specifically, S. epidermidis (2.1% to 26.2%), S. capitis (0.4% to 2.6%) and S. warneri (0.3% to 1.6%) using the CIM. The simplified CIM sampling method is an effective method for collecting corneal samples from patients with presumed MK in clinical practice.
Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix
Authors: Coffey Elizabeth C. , Astumian Mary , Alrowaished Sarah S. , Schaffer Claire , Henry Clarissa A.
Published: December 2021

Muscle development and homeostasis are critical for normal muscle function. A key aspect of muscle physiology during development, growth, and homeostasis is modulation of protein turnover, the balance between synthesis and degradation of muscle proteins. Protein degradation depends upon lysosomal pH, generated and maintained by proton pumps. Sphingolipid transporter 1 (spns1), a highly conserved gene encoding a putative late endosome/lysosome carbohydrate/H+ symporter, plays a pivotal role in maintaining optimal lysosomal pH and spns1−/− mutants undergo premature senescence. However, the impact of dysregulated lysosomal pH on muscle development and homeostasis is not well understood. We found that muscle development proceeds normally in spns1−/− mutants prior to the onset of muscle degeneration. Dysregulation of the extracellular matrix (ECM) at the myotendinous junction (MTJ) coincided with the onset of muscle degeneration in spns1−/− mutants. Expression of the ECM proteins laminin 111 and MMP-9 was upregulated. Upregulation of laminin 111 mitigated the severity of muscle degeneration, as inhibition of adhesion to laminin 111 exacerbated muscle degeneration in spns1−/− mutants. MMP-9 upregulation was induced by tnfsf12 signaling, but abrogation of MMP-9 did not impact muscle degeneration in spns1−/− mutants. Taken together, these data indicate that dysregulated lysosomal pH impacts expression of ECM proteins at the myotendinous junction.
At What Cost? Trade-Offs and Influences on Energetic Investment in Tail Regeneration in Lizards Following Autotomy
Authors: Barr James I. , Boisvert Catherine A. , Bateman Philip W.
Published: December 2021

Caudal autotomy, the ability to shed a portion of the tail, is a widespread defence strategy among lizards. Following caudal autotomy, and during regeneration, lizards face both short- and long-term costs associated with the physical loss of the tail and the energy required for regeneration. As such, the speed at which the individual regenerates its tail (regeneration rate) should reflect the fitness priorities of the individual. However, multiple factors influence the regeneration rate in lizards, making inter-specific comparisons difficult and hindering broader scale investigations. We review regeneration rates for lizards and tuatara from the published literature, discuss how species’ fitness priorities and regeneration rates are influenced by specific, life history and environmental factors, and provide recommendations for future research. Regeneration rates varied extensively (0–4.3 mm/day) across the 56 species from 14 family groups. Species-specific factors, influencing regeneration rates, varied based on the type of fracture plane, age, sex, reproductive season, and longevity. Environmental factors including temperature, photoperiod, nutrition, and stress also affected regeneration rates, as did the method of autotomy induction, and the position of the tail also influenced regeneration rates for lizards. Additionally, regeneration could alter an individual’s behaviour, growth, and reproductive output, but this varied depending on the species.
Learned Primal Dual Reconstruction for PET
Authors: Guazzo Alessandro , Colarieti-Tosti Massimiliano
Published: December 2021

We have adapted, implemented and trained the Learned Primal Dual algorithm suggested by Adler and Öktem and evaluated its performance in reconstructing projection data from our PET scanner. Learned Primal Dual reconstructions are compared to Maximum Likelihood Expectation Maximisation (MLEM) reconstructions. Different strategies for training are also compared. Whenever the noise level of the data to reconstruct is sufficiently represented in the training set, the Learned Primal Dual algorithm performs well on the recovery of the activity concentrations and on noise reduction as compared to MLEM. The algorithm is also shown to be robust against the appearance of artefacts, even when the images that are to be reconstructed present features were not present in the training set. Once trained, the algorithm reconstructs images in few seconds or less.
High-Resolution Scanning Coded-Mask-Based X-ray Multi-Contrast Imaging and Tomography
Authors: Qiao Zhi , Shi Xianbo , Wojcik Michael , Assoufid Lahsen
Published: December 2021

Near-field X-ray speckle tracking has been used in phase-contrast imaging and tomography as an emerging technique, providing higher contrast images than traditional absorption radiography. Most reported methods use sandpaper or membrane filters as speckle generators and digital image cross-correlation for phase reconstruction, which has either limited resolution or requires a large number of position scanning steps. Recently, we have proposed a novel coded-mask-based multi-contrast imaging (CMMI) technique for single-shot measurement with superior performance in efficiency and resolution compared with other single-shot methods. We present here a scanning CMMI method for the ultimate imaging resolution and phase sensitivity by using a coded mask as a high-contrast speckle generator, the flexible scanning mode, the adaption of advanced maximum-likelihood optimization to scanning data, and the multi-resolution analysis. Scanning CMMI can outperform other speckle-based imaging methods, such as X-ray speckle vector tracking, providing higher quality absorption, phase, and dark-field images with fewer scanning steps. Scanning CMMI is also successfully demonstrated in multi-contrast tomography, showing great potentials in high-resolution full-field imaging applications, such as in vivo biomedical imaging.
Bay Leaf Extract-Based Near-Infrared Fluorescent Probe for Tissue and Cellular Imaging
Authors: Adriano Benilde , Cotto Nycol M. , Chauhan Neeraj , Karumuru Vinita , Jaggi Meena , Chauhan Subhash C. , Yallapu Murali M.
Published: December 2021

The development of fluorescence dyes for near-infrared (NIR) fluorescence imaging has been a significant interest for deep tissue imaging. Among many imaging fluoroprobes, indocyanine green (ICG) and its analogues have been used in oncology and other medical applications. However, these imaging agents still experience poor imaging capabilities due to low tumor targetability, photostability, and sensitivity in the biological milieu. Thus, developing a biocompatible NIR imaging dye from natural resources holds the potential of facilitating cancer cell/tissue imaging. Chlorophyll (Chl) has been demonstrated to be a potential candidate for imaging purposes due to its natural NIR absorption qualities and its wide availability in plants and green vegetables. Therefore, it was our aim to assess the fluorescence characteristics of twelve dietary leaves as well as the fluorescence of their Chl extractions. Bay leaf extract, a high-fluorescence agent that showed the highest levels of fluorescence, was further evaluated for its tissue contrast and cellular imaging properties. Overall, this study confirms bay-leaf-associated dye as a NIR fluorescence imaging agent that may have important implications for cellular imaging and image-guided cancer surgery.
Understanding the Emotional Intelligence Discourse on Social Media: Insights from the Analysis of Twitter
Authors: Shankar Shardul , Tewari Vijayshri
Published: December 2021

Social networks have created an information diffusion corpus that provides users with an environment where they can express their views, form a community, and discuss topics of similar or dissimilar interests. Even though there has been an increasingly rising demand for conducting an emotional analysis of the users on social media platforms, the field of emotional intelligence (EI) has been rather slow in exploiting the enormous potential that social media can play in the research and practice of the framework. This study, thus, tried to examine the role that the microblogging platform Twitter plays in enhancing the understanding of the EI community by building on the Twitter Analytics framework of Natural Language Processing to further develop the insights of EI research and practice. An analysis was conducted on 53,361 tweets extracted using the hashtag emotional intelligence through descriptive analytics (DA), content analytics (CA), and network analytics (NA). The findings indicated that emotional intelligence tweets are used mostly by speakers, psychologists (or other medical professionals), and business organizations, among others. They use it for information dissemination, communication with stakeholders, and hiring. These tweets carry strong positive sentiments and sparse connectedness. The findings present insights into the use of social media for understanding emotional intelligence.
Intelligence Can Be Used to Make a More Equitable Society but Only When Properly Defined and Applied
Authors: Holden LaTasha R. , Hart Sara A.
Published: December 2021

In the US, undeniable evidence shows that socioeconomic inequities explain a high proportion of individual differences in school achievement. Although not all countries show this same effect due to socioeconomic status, it is consistently found that social inequities lead to achievement gaps. These achievement gaps then manifest into trajectories that set some individuals on a path of lower incomes, poorer health and higher mortality, lower wellbeing, and other poor adult outcomes. Like James Flynn so handily reminded the scientific literature that achievement gaps are explainable by environmental factors, the inequities we see around the world are based on environments some children are exposed to. In his work, Flynn stated his belief that the suppression of scientific work on intelligence would continue to lead to social inequities. We wish to take this idea and move it forward. We believe that the scientific construct of intelligence plays a key role in helping create a more equitable society through science. We also believe that the poor perception of intelligence, rooted in historical realities, means that it will continue to be misunderstood, feared, and misused, limiting how effective it could be in helping to close gaps in achievement and in creating a more equitable society.
Adaptive Intelligence: Intelligence Is Not a Personal Trait but Rather a Person × Task × Situation Interaction
Authors: Sternberg Robert J.
Published: December 2021

This article explores the advantages of viewing intelligence not as a fixed trait residing within an individual, but rather as a person × task × situation interaction. The emphasis in the article is on the role of persons solving tasks embedded in situations involving learning, intellectual abilities, and competencies. The article opens with a consideration of the role of situations in intelligent behavior. The article then discusses how intelligence is more similar to creativity and wisdom, in terms of the role of situations, than many psychologists have realized. Then the article reviews the role of situations in identity-based and irrational thinking and in conspiratorial thinking and cults. Next the article discusses the demonstrated importance of situations in assessment, but also notes the difficulties in sampling situations. Finally, the article draws conclusions, in particular, that, given our lack of situation-based tests, we need to be more modest in our interpretations results from conventional tests of intelligence.
Sustainable Development of Oil and Gas Resources: A System of Environmental, Socio-Economic, and Innovation Indicators
Authors: Cherepovitsyn Alexey , Rutenko Evgeniya , Solovyova Victoria
Published: December 2021

Following the principles of sustainable development in the development of oil and gas fields in the Arctic will ensure that hydrocarbon production and transportation operations comply with stringent environmental regulations, the economies of the northern regions become integrated into the national economy of Russia, production systems in the oil and gas sector are upgraded in an innovative manner, and further development of this region is balanced from the environmental perspective. The purpose of the study is to develop and provide a rationale for a balanced system of environmental, socio-economic, and innovative indicators for assessing whether the development of the Arctic’s unique hydrocarbon reserves is sustainable. The theoretical framework of the study draws upon the foundations and key principles of the sustainable development concept and upon modern approaches and methods for assessing the sustainability of production systems. The study presents an analysis of conceptual approaches to defining sustainable development in reference to oil and gas resources, including those found in the Arctic, defines target priorities for the sustainable development of the Arctic’s resource potential, and identifies the relationship between the environmental, socio-economic, and innovative domains of sustainability in the context of Arctic resource development. The results of the study demonstrate how large-scale gas projects can influence regional development and provide for making informed conclusions about whether the development of the Arctic’s oil and gas reserves can be considered sustainable (in accordance with the basic principles of the sustainable development concept).
Policies for Improving PM2.5 Particles and GHGs Emissions in a Maritime Port of Taiwan: Evidence Based on the INDC and GGRMA Regulations
Authors: Chang Ching-Chih , Tsai Yi-An
Published: December 2021

The impact of possible emission reduction policies designed to reduce port emissions in the Port of Kaohsiung in Taiwan was analyzed, focusing on ways to reduce air pollution from CO2, CH4, N2O, PM10, PM2.5, NOx, and SOx generated by vessels, cranes, and truck tractors in the port. This paper was set up in two stages to determine how pollution reduction policies could reach the 2030 and in 2050 goals. The results showed that emissions of CO2, CH4, N2O, PM10, PM2.5, NOx, and SOx could be reduced by 46%, 26%, 25%, 77%, 77%, 76%, and 68%, respectively, in the first stage (in 2030, INDC), and by 57%, 59%, 53%, 79%, 79%, 80%, and 69%, respectively, in the second stage (in 2050, GGGRMA), as compared to 2005 data. This paper concludes as follows: (1) for vessels, the use of liquid natural gas is the best way to reduce GHGs when navigating by water; (2) for bridge cranes, electrification is the better policy during operation; (3) in the case of truck tractors, the generation of battery-electric power is the best way to reduce emissions. These policy proposals for improving air quality can be applied to all ports in Taiwan.
Interannual to Interdecadal Variability of the Southern Yellow Sea Cold Water Mass and Establishment of “Forcing Mechanism Bridge”
Authors: Guo Yunxia , Mo Dongxue , Hou Yijun
Published: December 2021

The Yellow Sea cold water mass (YSCWM) occupies a wide region below the Yellow Sea (YS) thermocline in summer which is the most conservative water and may contain clearer climate signals than any other water masses in the YS. This study investigated the low-frequency variability of the southern YSCWM (SYSCWM) and established the “forcing mechanism bridge” using correlation analysis and singular value decomposition. On the interannual timescale, the southern oscillation can affect the SYSCWM through both the local winter monsoon (WM) and the sea surface net heat flux. On the decadal timescale, the Pacific decadal oscillation (PDO) can affect the SYSCWM via two “bridges”. First, the PDO affects the SYSCWM intensity by Aleutian low (AL), WM, and surface air temperature (SAT). Second, the PDO affects the SYSCWM by AL, WM, Kuroshio heat transport, and Yellow Sea warm current. The Arctic oscillation (AO) affects the SYSCWM by the Mongolian high, WM, and SAT. Before and after the 1980s, the consistent phase change of the PDO and the AO contributed to the significant decadal variability of the SYSCWM. Finally, one simple formula for predicting the decadal variability of SYSCWM intensity was established using key influencing factors.
Taphofacies and Petrofacies Theoretical Marine Models Applied to the Coquina of the Amaral Formation (Lusitanian Basin, Portugal)
Authors: Garcia Gustavo Gonçalves , Garcia Antônio Jorge Vasconcellos , Henriques Maria Helena Paiva , Marques Rafael Mendes , Pena dos Reis Rui
Published: December 2021

The Amaral Formation has a wide geographic distribution within the Lusitanian Basin, at the western Iberian Margin (Portugal). The different depositional contexts for this unit enabled the distinction of three sectors: lagoon, lagoon-barrier, and marine-distal. The integration of the evolutionary taphonomic analysis of its fossil assemblages with the analysis of multiscale properties through the CAMURES methodology (Multiscale Reservoir Characterization) allowed the application of a methodology for the classification of coquina which was previously developed for the Morro do Chaves Formation (Sergipe–Alagoas Basin, Brazil). Here, it was adapted according to the complexity of the Amaral Formation deposits. The classification of ten taphofacies, in association with four lithofacies, allowed the definition of 84 petrofacies, based on the nature of the sedimentary and taphonomic processes. The relationship between the structural context, the systems tracts, the diversity of the fossil record, the classification of taphofacies and petrofacies, and the understanding of vertical and lateral variations of the sediments’ deposition within the unit support the construction of geological and theoretical models for coquina deposits. These models will allow for prediction of the spatial distribution of facies in other coquina analogous hydrocarbon reservoirs, as well as specifying the delimitation of reservoir zones for 3D geocellular modeling and flow simulation of hydrocarbon-producing reservoirs, thus improving predictive analyses.
Probabilistic Storm Surge Estimation for Landfalling Hurricanes: Advancements in Computational Efficiency Using Quasi-Monte Carlo Techniques
Authors: Kyprioti Aikaterini P. , Adeli Ehsan , Taflanidis Alexandros A. , Westerink Joannes J. , Tolman Hendrik L.
Published: December 2021

During landfalling tropical storms, predictions of the expected storm surge are critical for guiding evacuation and emergency response/preparedness decisions, both at regional and national levels. Forecast errors related to storm track, intensity, and size impact these predictions and, thus, should be explicitly accounted for. The Probabilistic tropical storm Surge (P-Surge) model is the established approach from the National Weather Service (NWS) to achieve this objective. Historical forecast errors are utilized to specify probability distribution functions for different storm features, quantifying, ultimately, the uncertainty in the National Hurricane Center advisories. Surge statistics are estimated by using the predictions across a storm ensemble generated by sampling features from the aforementioned probability distribution functions. P-Surge relies, currently, on a full factorial sampling scheme to create this storm ensemble, combining representative values for each of the storm features. This work investigates an alternative formulation that can be viewed as a seamless extension to the current NHC framework, adopting a quasi-Monte Carlo (QMC) sampling implementation with ultimate goal to reduce the computational burden and provide surge predictions with the same degree of statistical reliability, while using a smaller number of sample storms. The definition of forecast errors adopted here directly follows published NWS practices, while different uncertainty levels are considered in the examined case studies, in order to offer a comprehensive validation. This validation, considering different historical storms, clearly demonstrates the advantages QMC can offer.
Distributed Swarm Control Algorithm of Multiple Unmanned Surface Vehicles Based on Grouping Method
Authors: Xia Guoqing , Sun Xianxin , Xia Xiaoming
Published: December 2021

This paper addresses the distributed swarm control problem of multiple unmanned surface vehicles (USVs) in Euclidean space with virtual leader. Firstly, to investigate the topology of the neighborhood relations between vehicles, a new time-variant topology structure is proposed. Secondly, to research the dynamic properties of the group for the case where the number of virtual leader is different, a grouping method based on cosine similarity is proposed. Thirdly, to ensure the high effeciency of information transmission and the reduction of costs, a distributed swarm control algorithm is proposed, which is mainly composed of three parts: gradient descent term, velocity consensus term and navigational feedback term. To analyze the stability of system, the concept of translation framework is introduced. Based on the properties of the Hamiltonian and LaSalle invariance principle, the stability of multiple USVs swarm motion is proved. Finally, simulation results illustrate the effectiveness of the proposed methods.
Sand Net Device to Control the Meanders of a Coastal River: The Case of the Authie Estuary (France)
Authors: Do Anh T. K. , Huybrechts Nicolas , Sergent Philippe
Published: December 2021

The Authie estuary is characterized by an important southern sand spit and a northern shoreline subject to strong erosion due to the meandering of the coastal river. In order to reduce this erosion, a new soft coastal defence, namely the sand net device (SND), has been implemented inside the Authie estuary. It consists of several nets assembled in an inverted V creating a porous structure and thus trapping sand as shoreline protection. However up to now, little proof has been provided on the explicit influence of this SND on the hydrodynamic pattern and associated morphodynamics. In this paper, field surveys of morphological developments combined with numerical modelling (Telemac-2D/3D) analyze the influence of the SND into flow pattern and morphodynamics. In situ monitoring clearly points out sedimentation around the SND and a deepening of the main channel. Modelling results show that, without SND, erosion is observed around its location. With a SND implemented, the velocity has been reduced and created a deviation in its direction by a circulation around the SND location. The impact area of the structure is around 500 m in both directions, upstream and downstream part.
Wave Interactions with Coastal Structures
Authors: Suzuki Tomohiro , Altomare Corrado
Published: December 2021

Due to the ongoing rise in sea level and increase in extreme wave climates, consequences of the changing wave climate, coastal structures such as sea dikes and seawalls will be exposed to severe and frequent sea storms [...]