bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the quality of life 10 years after bilateral thoracoscopic sympathicotomy in subjects with primary focal hyperhidrosis
Authors: Ergelasev Ivan , Kuhajda Ivan , Galic Marko , Lalic Nensi , Bojovic Marko
Published: July 2024

Introduction/Objective. Primary focal hyperhidrosis (PFH) is an idiopathic condition where excessive sweating affects one or more body regions, including axillae, palms, soles, and/or face. Most studies on quality-of-life (QoL) focus on the period up to one year after bilateral thoracoscopic sympathectomy (BTS). This study aims to determine the 10-year trend in QoL among patients from the Republic of Serbia with palmar-plantar-axillary PFH, treated with BTS at the R3?R4 level. A secondary goal is to ascertain the existence of compensatory sweating. Methods. All patients underwent a standardized BTS in a single act, through the cutting of ganglia with ultrasonic scissors at the R3?R4 level. For data collection, patients completed the ?Hyperhidrosis Quality of Life Questionnaire,? and the Hyperhidrosis Disease Severity Scale, preoperatively, postoperatively within 30 days, and 10 years after BTS. Results. The total sample consisted of 103 subjects who completed all three questionnaires. Considering the improvement in QoL from the group excellent, good, and average, the postoperative improvement was immediately postoperative in 88.4% of patients, while in the ten-year period, it was 87.4%. No statistically significant differences were found between the assessment of life satisfaction after 30 days and 10 years after BTS. Out of the total number of operated patients, two patients (1.94%) characterized their compensatory sweating as very pronounced. Conclusion. After 10 years from BTS, the QoL remains at an exceptionally high level, with an annual trend of decline of about 0.1%.
Design and Additive Manufacturing of Nerve Guide Conduits Using Triple Periodic Minimal Surface Structures
Authors: Numanoğlu Aybegüm , Şahin İsmail , Top Neslihan
Published: July 2024

Scaffold design is a key study area in tissue engineering. A scaffold is a three-dimensional framework that provides temporary support for the formation of new tissue before being implanted with isolated cells. The aim of tissue engineering scaffolds is to be colonized by cells. To ensure sufficient tissue growth, scaffolds need to transmit the necessary chemical and physical signals. The design of the scaffold determines its functionality. The design and manufacturing of tissue engineering scaffolds is a highly complex procedure. Scaffolds must have the necessary qualities to create an optimal architecture for cell growth, proliferation, and differentiation in order to form tissue. However, constrained structural designs and outdated manufacturing procedures impede the enhancement of scaffold qualities. To address these restrictions, researchers are merging computer-aided scaffold design with 3D printing processes during production. This method permits the design and manufacture of scaffolds with extremely intricate microstructures. The literature shows that computer-aided design combined with 3D printing technology is often utilized to design and manufacture nerve guide conduits for nerve regeneration. In this study, three different nerve guide conduit structures were designed and produced. Two of them are based on triple periodic minimal surfaces derived from Gyroid, schwarz. Although triple periodic minimal surfaces used as the basis for scaffold designs offer promising advantages for tissue engineering applications, limited information is available regarding their manufacturability. The designs created in this study, as well as their fabrication, will add to the literature on the manufacturability of triple periodic minimum surfaces.
The effects of moderate-intensity aerobic exercise on cognitive function in individuals with stroke-induced mild cognitive impairment: a randomized controlled pilot study
Authors: Huang Yuanling , Ou Haining , Zhao Weijian , Lin Qiang , Xue Yajing , Xia Rui , Tan Zhouchun , Zhao Xiaofang , Xiong Lifang , Yan Zeqin , Zheng Zubin , Wen Junbin
Published: July 2024

Objective: To assess the impact of moderate-intensity aerobic exercise on working memory in stroke-induced mild cognitive impairment (MCI).
Design: Randomized, double-blind controlled study.
Subjects and methods: Twenty MCI patients from the Fifth Affiliated Hospital of Guangzhou Medical University (December 2021 to February 2023), aged 34–79, 2–12 months post-stroke, were divided into an experimental group (EG) and a control group (CG), each with 10 participants. The EG underwent standard rehabilitation plus 40 minutes of aerobic exercise, while the CG received only standard therapy, 5 times weekly for 2 weeks. Working memory was tested using the n-back task, and overall cognitive function was measured with the MOCA and MMSE Scales before and after the intervention.
Results: The EG showed higher 3-back correctness (71.80 ± 14.53 vs 56.50 ± 13.66), MOCA scores (27.30 ± 1.57 vs 24.00 ± 3.13), and improved visuospatial/executive (4.60 ± 0.52 vs 3.30 ± 1.06) and delayed recall (4.30 ± 0.82 vs 3.00 ± 1.56) on the MOCA scale compared with the CG.
Conclusion: Moderate-intensity aerobic exercise may enhance working memory, visuospatial/executive, and delayed recall functions in stroke-induced MCI patients.
Patient’s Satisfaction Post-Transurethral Resection of the Prostate with Monopolar and Bipolar for Benign Prostate Hyperplasia
Authors: Duarsa Gede Wirya Kusuma , Pradiptha I Nyoman Tri , Sugianto Ronald , Mahadewa Tjokorda Gde Bagus , Prakoeswa Cita Rosita Sigit
Published: July 2024

Transurethral resection of the prostate (TURP), either bipolar or monopolar, is a surgical treatment for benign prostatic hyperplasia, which has similar effectiveness in reducing international prostate symptom score, increasing men peak flow rates, and reducing post-void residual volume. However, bipolar TURP (B-TURP) can reduce the incidence of bleeding and dilutional hyponatremia. This study aims to evaluate the effectiveness of the level of patient satisfaction between Monopolar-TURP (M-TURP) and B-TURP. 82 patients at three hospitals in Denpasar City were eligible as subjects based on inclusion criteria, consisting of 41 patients for each procedure. The recruitment method used consecutive sampling from March to August 2019. The patient’s demographics as baseline data were recorded. The level of patient satisfaction was recorded for one month after surgery through the SF-36 questionnaire. The baseline sample’s characteristics before surgery in both groups were statistically identical. In evaluating patient satisfaction levels, there are significant differences where TURP (B-TURP) is better in the domain of vitality (p=0.001), social function (p=0.005), pain (p=0.002), and general health (p=0.001). B-TURP resulted in an increasing level of patient satisfaction better than M-TURP.
Semana Municipal da Pessoa com Deficiência:
Authors: Lapuente Souza Katarine , Brandão Machado Juliana
Published: July 2024

O presente trabalho tem o objetivo realizar uma análise anticapacitista das Semanas Municipais da Pessoa com Deficiência do município de Jaguarão/RS. Para isso, parte do seguinte questionamento: de que forma as ações desenvolvidas na Semana Municipal da Pessoa com Deficiência contribuem com o combate ao capacitismo? A investigação foi realizada a partir de uma abordagem qualitativa, do tipo estudo de caso e utilizou como instrumentos de coleta de dados, a pesquisa documental e a técnica da entrevista. Os dados foram interpretados a partir dos procedimentos da análise textual qualitativa e revelaram que apesar de o termo capacitismo não ser utilizado, as ações são realizadas de modo a contribuir com o combate ao capacitismo. É de grande relevância que a discussão sobre capacitismo seja integrada às futuras edições deste evento.
The Role of Public Integrity in Controlling Corruption
Authors: Mutiah Adilah Sabrina , Gamayuni Rindu Rika , Oktavia Reni , Wulan Diajeng Fitri
Published: July 2024

This study aims to analyze the extent to which the Index of Public Integrity can be used to increase Perceived Corruption so that low and low-middle-income countries can form policies that will increase the country's ability to control corruption in the future. This study uses panel data from the Index of Public Integrity by ERCAS and the Corruption Perception Index by Transparency International in low and low-middle-income countries during 2016 – 2022. Regression analysis, t-test, and R-Square were done using EViews 9 software. Test results show Administrative Transparency, Online Services, Freedom of the Press, and Judicial Independence positively influence the Corruption Perception Index so that it can be used as a major consideration in formulating government policies and regulations to reduce corruption. Meanwhile, E-Citizenship has no influence and Budget Transparency has a negative relationship with Perceived Corruption because of the legal culture. This research can contribute a basis and consideration in preparing government policies aimed at controlling the level of corruption in a country.
RANCANG BANGUN SISTEM LOKET ANTRIAN PELANGGAN DI PT LINGKAR KABEL TELEKOMUNIKASI
Authors: Pratama Yogi Setyawan Putra , Rahayu Agustina Sri , Wijianto Wijianto
Published: July 2024

Penelitian ini membahas aplikasi antrian pelanggan di PT Lingkar Kabel Telekomunikasi menggunakan metode waterfall.tujuannya adalah untuk meningkatkan efisiensi operasional dan kepuasan pelanggan dalam mengambil nomer antrian dan memudahkan admin dalam mengelola antrian. Metode waterfall di gunakan secara trestruktur di mulai dari analisis kebutuhan,desain sistem,implementasi,pengujian hingga penerapan dan pemeliharaan. Antrian ini menyediakan fitur ambil nomer secara digital. Hasil menunjukkan penurunan dalam waktu pembuatan nomer antrian karna admin tidak susah untuk membuatkan nomer antrian secara manual dan adminjuga tidak perlu menginput nomor antrian secara manual. Kesimpulan aplikasi antrian berhasil memenuhi tujuan utama meningkatkan evisiensi pelayanan dan memberikan pengalaman yang lebih mudah bagi pelanggan yang ingin ambil nomer antrian dan admin yang menginput data antrian.
Stimulasi Kemampuan Berpikir Komputasional pada Anak Usia Dini di Era Digital
Authors: Sipahutar Rini Juliana , Silalahi Natalia
Published: July 2024

Di era digital, kemampuan berpikir komputasional adalah keterampilan fundamental yang harus dikembangkan sejak usia dini. Anak-anak yang familiar dengan teknologi cenderung lebih mudah memahami konsep dasar komputasi seperti algoritma, logika, dan pemecahan masalah. Penggunaan alat bantu digital dan aktivitas bermain yang dirancang secara khusus dapat secara signifikan menstimulasi kemampuan berpikir komputasional. Oleh karena itu, penting bagi para pendidik dan orang tua untuk secara strategis mengintegrasikan teknologi dan kegiatan komputasional ke dalam pendidikan anak usia dini. Penelitian ini bertujuan untuk mengeksplorasi bentuk kegiatan dan media yang dapat digunakan dalam melatih kemampuan berpikir komputasional. Penelitian ini merupakan systematic literature review dengan pendekatan PRISMA. Literatur didapatkan dari berbagai perpustakaan digital seperti Google Scholar, Scopus, ResearchGate dan Springer yang terbit di antara 2018-2024. Berdasarkan 6 naskah terpilih, disebutkan bahwa terdapat berbagai kegiatan seperti permainan konvensional dan pemrograman yang digunakan untuk menstimulasi kemampuan berpikir komputasional. Media yang digunakan antara lain building block, visual programming application dan robot.
BAGURAU SALUANG DENDANG IN THE PERFORMANCE LAPIAK GURAU IN THE MINANGKABAU COMMUNITY IN TANAH DATAR DISTRICT: CONTINUITY CHANGE AND FUNCTION
Authors: Amelia Putri Chairina , Nasution Ikhwanuddin , Sebayang Vanesia Amelia
Published: July 2024

The Bagurau Saluang Dendang performance referred to in this research is the Bagurau Saluang Dendang performance at the Lapiak Gurau event, literally meaning 'joking on a mat', which usually occurs in many coffee shops in Tanah Datar Regency. This show is an entertainment show. This thesis aims to analyse the changes that occur in the Lapiak Gurau Saluang Dendang (TLGSD) tradition performance today. This performance is usually performed at night, from 20.00 WIB until dawn. The accompanying instrument for singing in this performance is usually only the saluang musical instrument. Meanwhile, the singers are only men. This is because traditional rules prohibit the participation of women in bagurau art. In the early 2000s, changes began to occur. In fact, nowadays, TLGSD performances are held from 22.00 WIB until just before dawn. The cast in TLGSD currently numbers ten people, with details: one saluang player, one keyboard player, one Janang, four singing children, and three singing parents. Changes in the mindset of the Minangkabau people in the last three or four decades have had an impact on the orientation of TLGSD performances. The changes in question predominantly occurred in aspects of the procedures for performing lapiak gurau, including traditional norms for female singers, the choice of ensemble format used as accompaniment to the song, and the text of the pantun. The method used in this research is a qualitative-descriptive method using an ethnographic perspective. The results of this research show that the tradition of lapiak gurau saluang dendang has undergone changes: (i) the choice of instruments to accompany the dang that is popular with audiences is now more modern; (ii) the majority of singers currently in demand as singers are women; (iii) weakening the role of the ninik mamak as traditional elders who are supposed to protect the dignity of Minangkabau women. However, TLGSD is now contributing to increasing the financial income of stall owners.
USE SOCIAL MEDIA WISELY IN ACCORDANCE WITH APPLICABLE PROVISIONS
Authors: Umar Santoso Budi Nursal , Rahmat Doris
Published: July 2024

Social media has become an integral part of everyday life, opening up unprecedented opportunities for communication, collaboration and information exchange. However, with the freedom offered by these platforms also comes the great responsibility to use them wisely and in accordance with applicableregulations. This research aims to explore wise practices in the use of social media and their impact on individuals and society. Through a qualitative approach, data was collected through in-depth interviews and observations of various social media users. The research results show that awareness of privacy, diversity ofopinions, control of posted information, and openness to other people's perspectives are important factors in using social media wisely. Apart from that, this researchalso identifies the challenges and obstacles faced in efforts to make social media a positive communication tool. These findings provide valuable insights forindividuals, institutions, and regulators to develop policies and practices that promote responsible and ethical use of social media. . From the research results, itappears that social media users have varying levels of awareness of the terms of use, but compliance with these rules can vary depending on factors such aspeer pressure, the complexity of the rules, and the influence of the social and cultural environment. Challenges in practicing wise use of social media are alsoapparent, ranging from the pressure to maintain a perfect image to the  difficulty in distinguishing between valid information and hoaxes. In addition, the positive impacts of social media, such as social connectivity and access to information, are also accompanied by negative risks, including the spread of hoaxes and mental stress. The influence of the social and cultural environment on social media usage practices reinforces the importance of taking into account an individual's social and cultural context in developing appropriate approaches to managing risks and maximizing the benefits of social media. In this context,awareness of the positive and negative impacts of social media is key to helping individuals and society develop more responsible and ethical practices in the use of these platforms. A holistic approach is needed that combines education, social support, and supportive policies to create a healthy and productive onlineenvironment for all users
КОРЕКЦІЯ СЕНСОРНОГО РОЗВИТКУ МОЛОДШИХ ШКОЛЯРІВ З ПОРУШЕННЯМИ ЗОРУ
Authors: Зорочкіна Тетяна ,   Черкаський національний університет імені Богдана Хмельницького, Ніколаєску Інна , Литвин Інна
Published: July 2024

У статті розкрито особливості сенсорного розвитку молодших школярів з порушеннями зору. Визначено основні принципи корекції сенсорного розвитку дітей з порушеннями зору: використання різних сенсорних стимулів; застосування спеціальних методик вправ і тренувань для розвитку сенсорних навичок; диференціація інформації за допомогою різних способів подання; постійне використання кольорових та контрастних матеріалів; створення комфортних умов для сприйняття інформації; індивідуалізація освітнього процесу. Висвітлено особливості корекційно‐розвиткової роботи з дітьми з порушеннями зору. Розглянуто основні завдання корекційно‐розвиткових занять з молодшими школярами. Здійснено аналіз корекційно‐ розвиткових програм для учнів 1‐4 класів з порушеннями зору, що затверджені Міністерством освіти і науки України.
ПОТЕНЦІАЛ ВИКОРИСТАННЯ ІНФОРМАЦІЙНО‐КОМУНІКАЦІЙНИХ ТЕХНОЛОГІЙ ДЛЯ ФОРМУВАННЯ ФАХОВОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ ТЕХНІКІВ‐ЕЛЕКТРИКІВ У КОЛЕДЖІ
Authors: Герлянд Тетяна ,   Інститут професійної освіти НАПН України
Published: July 2024

У зв’язку з розробленням та застосуванням сучасних інформаційно‐ комунікаційних технологій (далі – ІКТ) у всіх сферах діяльності науки, техніки, освіти та промисловості на сучасному етапі розвитку країни підготовка майбутніх фахівців, здатних використовувати свої знання на виробництві із застосуванням цих технологій є першочерговим завданням для викладачів фахової передвищої освіти. Підготовка конкурентоспроможного техніка‐електрика, адаптованого до життя та професійної діяльності, вимагає від викладача коледжу застосування відповідних інформаційно‐комунікаційних технологій для ефективного формування фахової компетентності майбутнього фахівця. Мета статті – дослідження потенціалу використання інформаційно‐ комунікаційних технологій для формування фахової компетентності майбутніх техніків‐електриків у коледжі. Розглянуто методику комплексного використання ІКТ у процесі вивчення електротехнічних дисциплін для ефективного формування фахової компетентності майбутнього фахівця. Доведено, що використання мультимедійних лекцій та практичних занять (віртуальних лабораторій) дає змогу підвищити ефективність та якість навчання, а також надає можливість у більшому обсязі надати пояснення навчального матеріалу для студентів, підвищити їх інтерес до електротехнічних дисциплін. Таким чином, явні переваги застосування ІКТ, мультимедійних технологій в організації освітнього процесу не викликають сумніву. Саме застосування ІКТ володіє вагомим потенціалом у формуванні фахової компетентності майбутніх техніків‐електриків, які після закінчення навчання у коледжі надалі будуть використовувати свої знання на виробництві із застосуванням нових інформаційних технологій.
СУЧАСНІ МЕТОДИКИ ФОРМУВАННЯ ПРОФЕСІЙНОЇ КУЛЬТУРИ МАЙБУТНЬОГО ВИКЛАДАЧА
Authors: Козленко Володимир ,   Мережа приватних шкіл «Креативна міжнародна дитяча школа»
Published: July 2024

Стаття є актуальної для сучасної освіти, містить важливі теоретичні положення та практичні рекомендації щодо формування професійної культури майбутнього викладача. Метою статті є вибір та обґрунтування сучасних методик формування професійної культури майбутнього викладача. Автором було застосовано такі загальнонаукові методи дослідження: аналіз, синтез, порівняння, структурно‐логічний, аналогія, узагальнення. У тексті робиться акцент, на тому, що сучасний викладач повинен володіти не лише глибокими знаннями та професійними навичками, а й високою професійною культурою. Обґрунтовано положення, що професійна культура викладача охоплює сукупність його знань, умінь, навичок, цінностей, установок, що забезпечують ефективну професійну діяльність. Виділено сучасні дидактичні методики формування професійної культури майбутніх викладачів: тренінги, які дозволяють майбутнім викладачам опанувати необхідні професійні вміння та навички через практичні заняття; кейс‐метод, який розвиває професійне мислення та вміння розв’язувати педагогічні проблеми; проектне навчання, яке формує здатність реалізовувати педагогічні ідеї та працювати в команді; інформаційно‐комунікаційні технології, які забезпечують доступ до світових освітніх ресурсів; майстер‐класи, які дозволяють переймати досвід професіоналів у вирішенні практичних завдань. У висновках та перспективах подальших досліджень охарактеризовано використання інтерактивних технологій, методик для розвитку творчої особистості майбутніх викладачів та формування професійної культури.
THE FORMATION OF FUTURE DOCTORS’ MANAGERIAL COMPETENCE: EXPERIENCE IN LEADING INSTITUTIONS OF HIGHER MEDICAL EDUCATION IN UKRAINE
Authors: Myskiv Maksym ,   Lviv Polytechnic National University
Published: July 2024

The article deals with the problem of future doctor’s managerial competence formation. The aim of the article is as follows: to analyze the educational programs of future doctor’s training in the leading medical higher education institutions in Ukraine in the context of their managerial competence formation. The article highlights the results of scientific literature analysis. The author substantiates the criteria for selection of institutions of higher medical education of Ukraine, the experience of which is studied. The article presents the results of the analysis of educational programs for future doctors’ training and determines its common features as well as compliance with the Standard of higher education for the second (master’s) level of higher education in speciality 222 Medicine. It is proved that most institutions of higher medical education offer optional courses, which form separate components of the managerial competence of a future doctor in such professional domains as “cooperation”, “services”, and “the development of profession”. The issues of forming managerial competence for the implementation of one’s own professional activity and professional development of doctors, promoting the development of professional community, improving services, introducing changes, etc., remain outside the attention of educational programs’ developers. The conclusion is made that there are gaps both in educational programs and in the knowledge of medical students regarding the need to master managerial knowledge, skills and abilities, as well as their application in professional activities. Such conclusions provide grounds for the development of scientific and methodical recommendations for solving this issue.
Filosofía y crítica social. De la razón histórica a la cultura nacional en el pensamiento de Rodolfo Agoglia
Authors: Karczmarczyk Pedro
Published: July 2024

El presente trabajo se propone esclarecer la función que cumple la reflexión sobre el problema de la cultura nacional en el proyecto filosófico del pensador argentino Rodolfo Mario Agoglia. Para ello, intentaremos trazar un recorrido que se inicia con el problema de la razón histórica, enmarcado en la crisis de las filosofías sustantivas de la historia, que desemboca, a través de un desarrollo problemático que intentaremos subrayar, en la cuestión de la cultura nacional. Destacaremos los puntos de contacto que el desarrollo de la noción de razón histórica tiene con los proyectos de crítica de la ideología, concebidos como justificación filosófica de la crítica social (y en última instancia en el marco de una visión donde la filosofía misma es tal instancia crítica). Intentaremos presentar los lineamientos generales de la propuesta de Agoglia, concentrándonos en las propuestas que apuntan a esclarecer las condiciones de posibilidad y justificación de una razón histórica, en un doble sentido, como razón capaz de conocer la historia, y como razón inserta en la historia. Mostraremos que la articulación de razón histórica y cultura nacional viene dada por la reflexión sobre el problema de la eficacia de la crítica cultural y social.
La virtud cívica republicana en las sociedades contemporáneas. Resumen de Tesis de Doctorado en Filosofía de Marcelo Fernández Pavlovich
Authors: Fernández Pavlovich Marcelo
Published: July 2024

Resumen de tesis de Doctorado en Filosofía: La virtud cívica republicana en las sociedades contemporáneas de Marcelo Fernández Pavlovich.Directora: Dra. Graciela Vidiella. Fecha de defensa: 13 de setiembre de 2023
Strategi Guru (SAGU) dalam implementasi HOTS pada Pembelajaran di SD INPRES Polder Merauke: Sebuah Analisis
Authors: Nirtha Eva , Rival Hanip  , Yonarlianto Tembang
Published: July 2024

High Order Thinking Skills (HOTS) are crucial in the education era of Revolution 5.0, requiring teachers to incorporate these skills into their teaching. However, many teachers face challenges in fully implementing HOTS due to various internal and external factors. This qualitative descriptive study analyzes the strategies used by teachers at SD Inpres Polder in Merauke for implementing HOTS. The research involved 18 teachers and employed data collection techniques such as in-depth interviews, classroom observations, and documentation studies of lesson plans and curricula. The results indicate that teachers employ several strategies to integrate HOTS, including designing learning activities and tasks oriented towards HOTS, providing feedback to develop thinking skills, and collaborating with students for complex problem-solving. Additionally, they use resources that stimulate reflective and critical thinking. However, teachers also encounter challenges such as limited time, curriculum adjustments, and diverse student backgrounds. In conclusion, while teachers at SD Inpres Polder have adopted various strategies to implement HOTS, they need further support to enhance these strategies. Collaborative efforts from schools, parents, and policymakers are essential to help teachers develop their professionalism and effectively apply HOTS in their teaching.
Aktualisasi Program Kampus Mengajar Melalui Pelaksanaan Kegiatan Kaya Literasi dan Numerasi di SD Negeri Dungkek III
Authors: Efendi Surya Fajar , Rozie Fachrur
Published: July 2024

This research aims to identify activity programs that can be carried out by Kampus Mengajar 7 in an effort to create an environment and habituation to literacy and numeracy activities at SD Negeri Dungkek III. This is motivated by the lack of average ability of Indonesian students in literacy and numeracy in the last 3 years based on PISA data. The main focus of the Kampus Mengajar program is targeting level 1 and 2 schools based on the results of the National Assessment. This research uses descriptive qualitative research methods with data collection techniques, namely interviews, observation and documentation. The results of this research explain the role of students' active contribution in the actualization of the Kampus Mengajar program as teacher partners, socializers of the Ministry of Education and Culture's learning products, technology adaptation, as well as collaborative learning variations in the classroom as well as identifying activity programs that can be implemented to boost students' literacy and numeracy skills.
Building a Strong Foundation in English with Phonics Method among the First Graders of Elementary School in Magelang
Authors: Putri Aprilian , Jayanti Widya , Fortinasari Paulina , Putri Nabila , Meili Amandha  , Firdaus Muhammad
Published: July 2024

This study aims to assess the efficacy of the phonics method in improving the English language proficiency of Indonesian first-grade elementary school students. The core group of 32 participants consisted of fifteen female and seventeen male students in the observation and interview techniques used to collect data. The results of this study showed that the phonics method can help increase the vocabulary of early childhood students, as the students can pronounce the letters correctly and remember the sounds of the letters and words. The findings show that the phonics method strengthens their early understanding of English by assisting first-graders in building a solid foundation. The study's findings showed that there are differences in the learning outcomes of beginning reading in students who follow the use of audio-visual media and in students who do not use audio-visual. Phonic method helped students build a solid foundation in reading, which in turn strengthened their foundation for English language proficiency. This study emphasizes the importance of phonics as a powerful teaching tool for developing reading skills in the early stages of formal education.
Kinerja Karyawan Divisi Sales Di PT. X Ditinjau Dari Motivasi Kerja
Authors: Cahyadi Andi , Matius Wahyu Bannon Tri Nugroho
Published: July 2024

Penelitian ini bertujuan untuk mencari tahu keterkaitan antara motivasi kerja dengan kinerja karyawan pada divisi sales di PT. X Madiun. metode yang digunakan di dalam penelitian ini menggunakan metode kuantitatif dengan analisis uji hubungan. Skala kinerja dan skala motivasi kerja merupakan alat pengumpul data yang digunakan dalam penelitian ini. Responden yang terlibat di dalam penelitian ini sejumlah 40 karyawan, yang memiliki karakteristik yaitu karyawan yang bekerja  di PT.X  Madiun, bagian sales dan mempunyai masa kerja di atas satu tahun. Di dalam penelitian ini peneliti menggunakan total sampling sebagai teknik pengambilan sampel, dikarenakan responden kurang 100. Pearson product moment digunakan di dalam penelitian ini untuk menganalisis seberapa kuat hubungan antara kedua variabel tersebut. Hasil penelitian yang diperoleh yaitu koefisien sebesar r = 0.780 dengan p = 0.000 (p < 0.05) dengan arah korelasi positif, artinya terdapat hubungan yang signifikan antara motivasi kerja dengan kinerja karyawan di divisi sales pada PT X di Madiun, semakin tinggi motivasi kerja yang dimiliki oleh karyawan divisi sales PT X, maka akan semakin tinggi pula kinerjanya. Mengacu pada hasil penelitian, maka bisa diambil sebuah kesimpulan bahwa agar karyawan divisi sales pada PT X memiliki kinerja yang baik, maka yang perlu dilakukan adalah dengan menumbuhkan motivasi kerjanya.
Emotional banking with a digital avatar: A PLS-SEM based study based on para-social relationship theory
Authors: Malhotra Nishi , Saravanan P. , Shah Pankaj
Published: July 2024

Purpose: The major objective of this study is to measure the impact of various attributes, such as social attraction, physical attraction, and task attraction on para-social relationships. The study also seeks to measure how the para-social relationship mediates the association between the three attributes (above-mentioned) on perceived credibility and informational influence, and consumers’ intention to purchase banking products. Study design/methodology: PLS-SEM has been used as it is believed to be most suited for the study due to the multivariate non-normality in the data, and the small sample size. Data has been collected using the 5-point Likert scale from approximately 151 respondents, who were selected using the non-random sampling method based on purposive sampling coupled with convenience-based sampling. The data was collected from January 2023 to August 2023. Findings: Largely, the findings reveal that both social and physical attractions do have a positive impact on the para-social relationship, further leading to perceived credibility and informational influence. Notably, this perceived credibility and informational influence lead to consumers’ intentions to purchase banking products, albeit with the use of artificial intelligence-based chatbots and digital assistants. Originality: This is possibly among the first-ever studies extending the para-social theory for purchasing banking products and services using artificial intelligence-based chatbots and virtual assistants.
Human Skin Microbiota – Essentials for Beauty Studio Professionals
Authors: Gajdka Weronika , Rakoczy Rafał , Augustyniak Adrian
Published: July 2024

Skin, the largest organ in the human body, presents the largest possible area for colonization by microorganisms. The aspects of the interaction between microbiota and the host cannot be omitted during procedures in a beauty studio. Professional cosmetologists should consider their work’s impact on skin biodiversity and know the probable consequences. This review reviewed the current state of the art on skin microbiota with a focus on the connection between body area, microbiological biodiversity and the outcome of cooperation between the host and microorganisms. The role of the skin microbiota in maintaining the host’s homeostasis was also summarized.
Gonococci – Pathogens of Growing Importance. Part 2. Virulence Factors, Antimicrobial Resistance and Vaccine Development
Authors: Białecka Joanna , Rak Katarzyna , Kiecka Aneta
Published: July 2024

Neisseria gonorrhoeae (gonococcus) is a human pathogen, the aetiological agent of gonorrhoea, which is the second most common bacterial sexually transmitted disease (STD) in the world. The structure of N. gonorrhoeae cell wall is typical of Gram-negative bacteria, poses variable antigens porin B (PorB), and opacity-associated proteins (Opa proteins), lipooligosaccharide (LOS) and type IV pili (TFP) playing an essential role in pathogenesis. In addition to adhesins, gonococcus presents other virulence factors such as reducing modifiable protein (Rmp), iron transporters, membrane pumps, and IgA peptidase. The pathogen produces outer membrane vesicles (OMVs), releases peptidoglycan (PG) fragments and is well adapted to develop infection in diverse niches of the female and male reproductive tracts. The characteristic genotypic trait of N. gonorrhoeae is the state of natural competence, which allows DNA uptake from the environment. The antigenic and phase variability is essential to gonococcal defence against the human immune system. Because of the increasing antimicrobial resistance (AMR) of N. gonorrhoeae and the high incidence rate of gonococcal infections, developing an antigonococcal vaccine has become an urgent need. Vaccine development difficulties are mainly due to the gonococcal ability of immune evasion, the lack of an animal model, and the limited understanding of protective immune response mechanisms.
Co-infection with Mycobacterium tuberculosis and Mycobacterium avium in an HIV-positive patient – Case Report
Authors: Roman Aura-Alisia , Tripon Ioana , Tudor Bianca
Published: July 2024

Introduction: The association between Mycobacterium tuberculosis and the Human Immunodeficiency Virus can accelerate the deterioration of immunological functions. The risks are even more accentuated in the situation of a Non-tuberculous Mycobacterium and Mycobacterium tuberculosis co-infection.

Case presentation: We present the case of a 59-year-old male patient, who was admitted at the hospital with non-specific symptoms. Further investigations reveal a remarkable particularity about the case: The infection with Mycobacterium tuberculosis was urogenital, whereas the one with Non-tuberculous mycobacteria was pulmonary.

Conclusion: Both Mycobacterium tuberculosis and Non-tuberculous strains can exist within the same infection, posing great difficulties for diagnosis, as well as the treatment scheme.
Effect of carbamazepine-beta-cyclodextrin inclusion complex on seizure-like events in an in vitro model of temporal lobe epilepsy
Authors: Kiss Rita-Judit , Csüdör Ágnes , Sárosi Máté , Nagy Zsolt András , Szentes Ádám , Gáll Zsolt , Szilágyi Tibor , Orbán-Kis Károly
Published: July 2024

Objective: Pharmacoresistant epilepsy represents a significant global health challenge, necessitating novel therapeutic approaches. Despite advances in antiseizure medications, many patients remain treatment-resistant partially due to complex pharmacokinetic issues. Beta-cyclodextrin, known for enhancing drug solubility and stability, offers potential solutions by forming inclusion complexes, thereby improving anti-seizure medication’s efficacy. This study aimed to investigate the effect of beta-cyclodextrin and beta-cyclodextrin-complexed carbamazepine on epileptiform activities, using an in vitro model of temporal lobe epilepsy.

Methods: Seizure-like neuronal activity was induced using the low-magnesium model. Local field potentials were recorded from transverse rat hippocampal slices immersed in epileptogenic artificial cerebrospinal fluid, followed by the administration of either beta-cyclodextrin or carbamazepine, the latter in 100 micromolar concentration.

Results: Beta cyclodextrin, applied alone, significantly reduced the duration of interictal and ictal phases while increasing the frequency of seizure-like events. Carbamazepine exhibited an important anticonvulsant effect, significantly reducing ictal and postictal phase durations. However, the frequency of seizure-like events was increased. Notably, in some of the slices, carbamazepine completely suppressed epileptiform activity.

Conclusions: Beta cyclodextrin had an effect on its own; it shortened seizure durations and increased their frequency. Carbamazepine in complexed form, as used in our study, exhibited anticonvulsant efficacy, emphasizing the feasibility of solubility enhancement by this method. This study provides insights into potential therapeutic strategies for pharmacoresistant temporal lobe epilepsy, improving the pharmacological properties of the drugs. As cyclodextrins emerge as promising excipients for antiepileptic drugs with poor solubility, more effort is needed in order to elucidate the underlying mechanisms of their effects.
Beneficial effects of Anemone palmata extracts on male rabbit fertility and reproduction
Authors: Meziani Asma , Hafid Hinda , Allaoua Noua , Boulahbel Souad , Bentayeb Yasmina , Moumen Yasmina , Siouani Amina , Gherraf Noureddine
Published: July 2024

Objective: The current study is intended to offer an insight on positive benefits of the herb Anemone palmate belonging to Ranunculaceae family, as an enhancing agent of male rabbit’s fertility.

Methods: Twelve male rabbits, in the growth stage, were divided randomly into four equal groups: one serving as the control and three subjected to different treatments. Anemone palmata extracts (50, 100, and 200 mg/kg) were administered orally to the groups. Blood samples were collected to measure the serum levels of testosterone four weeks later. The weight of the testis and epididymis, sperm count, and sperm motility were determined histologically.

Results: The findings revealed a significant increase in the relative weights of the reproductive organs (testis and epididymis) and plasma testosterone levels in the groups that received the 100 and 200 mg/kg doses. Moreover a notable enhancement in the spermatozoa biology, including concentration, motility, and speed, was observed in the groups treated with 100 and 200 mg/kg doses compared to the control and the group treated with 50mg/kg. The histological study revealed some changes in the spermatogenesis and the structure of the organs, involving the presence of the spermatid phase. A significant increase in the thickness of seminiferous walls, a decrease in the interstitial space, and a reduction in the lumen and intra-tubular spaces were observed as well.

Conclusions: it is well indicated that Anemone palmata could improve fertility factors, and exhibit good effects on gonad and sperm parameters in rabbits.
Ex vivo permeability study and in vitro solubility characterization of oral Canagliflozin self-nanomicellizing solid dispersion using Soluplus® as a nanocarrier
Authors: Jassem Nizar Awish , Alhammid Shaimaa Nazar Abd
Published: July 2024

Background and objective: Self-nanomicellizing solid dispersion SNMSD is a new formulation that combines solid dispersion and nanomicelle strategies; the strategy involves utilizing a suitable carrier that self-assembles into nanomicelles when interacting with gastrointestinal fluids. Canagliflozin, a sodium-glucose cotransporter-2 inhibitor for treating type 2 diabetes, has been linked to poor absorption due to its insolubility in aqueous media. The study aimed to create self-nanomicellizing solid dispersion systems for canagliflozin to overcome its pharmaceutical limitations and improve oral bioavailability.

Materials and Methods: Soluplus® was chosen as a nanocarrier to improve canagliflozin solubility after screening several polymers using a phase solubility study. The solvent evaporation method was selected for preparing the solid dispersion. The optimal formula was characterized through ex vivo permeability and in vitro studies.

Results: The CFZ-SNMSD formula, with a particle size PS of 60.77±1.00 nm and polydispersity index PDI of 0.06±0.02, has a stable distribution upon dilution to 20-fold with water. The apparent solubility of canagliflozin in the optimized CFZ-SNMSD formula was enhanced by 904.40±4 folds due to amorphization and nanomicellization, as demonstrated by transmission electron microscopy. CFZ-SNMSD formula showed a significant enhancement in dissolution rate compared to the physical mixture and pure drugs. The dissolution efficiency parameter confirms these findings (DE30, CFZ-SNMSD = 77.20% compared to DE30, pure drug = 18.28%). Studies show that canagliflozin’s permeability increases exponentially over time due to Soluplus® dispersibility, solubilization, and glycoprotein inhibitory effect, enhancing bioavailability and overcoming GIT membrane barriers. Conclusions: The study indicates that canagliflozin self-nanomicellizing solid dispersion systems are promising methods for improving the oral bioavailability of canagliflozin medication.
Cannabidiol, a promising therapy for post-traumatic stress disorder and depression. A mini-review
Authors: Jîtcă George
Published: July 2024

Post-traumatic stress disorder (PTSD) is a mental health disorder, manifesting in people who have endured traumatic events like violence, war, natural disasters, accidents, or other life-threatening situations. Essentially, PTSD is a chronic and debilitating disorder, significantly impacting mental health and psychosocial well-being, necessitating the exploration of novel treatment approaches. Although conventional therapies like psychotherapy and antidepressants have demonstrated efficacy for certain individuals, their effectiveness is limited for some and minimal for others. Consequently, researchers and clinicians are investigating alternative therapeutic methods for these conditions. Among these emerging treatments, cannabidiol (CBD) has shown promising results. Nevertheless, early studies suggest that CBD might yield positive outcomes in mitigating symptoms related to both depression and PTSD.
Business Models of Enterprises in the Conditions of Digital Transformation: Global and Domestic Experience
Authors: Shostak Liudmyla , Lipych Liubov , Anatolii Fedoniuk , Volynets Iryna , Andrew Ulyanytsky , Morokhova Valentyna
Published: July 2024

The article aims to provide a comprehensive overview of both theoretical concepts and practical applications regarding the transformation of business models in the context of digitalizing the economy. In the current digital landscape, traditional business models may no longer suffice to sustain growth and competitiveness. Therefore, there is a pressing need to identify and adopt novel approaches that leverage digital technologies to their fullest potential. By examining the latest trends and emerging paradigms in economy’s, the article aims to re-think their strategies and embrace digital transformation proactively. This involves not only incorporating technology into existing operations but also reimagining the entire business model to capitalize on new opportunities and address evolving consumer behaviors. Furthermore, the article aims to provide practical insights and actionable recommendations for businesses looking to embark on their digital transformation journey.
The Impact of Inflation on Financial Sector Performance: Evidence from OECD Countries
Authors: Bilalli Argjira , Sadiku Murat , Sadiku Luljeta
Published: July 2024

This research article investigates the relationship between inflation and the performance of the financial sector within OECD countries, a group critical to global economic stability. The financial sector is a basis of sustainable economic growth, and its performance is heavily influenced by the macroeconomic environment, particularly inflation. This study analyses how inflation, alongside other significant factors such as real GDP growth, government size, trade openness, and interest rates, impacts the financial sector development. By examining data from 38 OECD countries over a 20-year period (2002-2021), this research employs a comprehensive approach using both static and dynamic panel regression models. The results consistently indicate a negative correlation between inflation and the key financial sector variables, suggesting that higher inflation levels undermine financial sector performance. These findings underscore the importance of maintaining low and stable inflation to foster an efficient and stable financial sector. This study makes a valuable contribution to the literature by focusing specifically on OECD countries, which are often seen as benchmarks for economic policies and financial systems.
Researches on the Mobility and Toxicity of Heavy Metals from Balomir Tailings Dump – Uricani Jiu Valley
Authors: Ioniţă Mădălina-Flavia , Radu Sorin Mihai , Dunca Emilia Cornelia
Published: July 2024

Coal mining is a vital industrial activity but often associated with negative environmental effects, including the accumulation of waste containing heavy metals in tailings dump. These heavy metals, such as lead, chromium, copper, zinc, cadmium, mercury, and others, pose significant risks to the environment and human health. The mobility of these heavy metals is a major concern, as they can be released into soil and water during rain or erosion processes, contaminating water sources and affecting aquatic and terrestrial life. These metals can be taken over by plants and eventually end up in the trophic chain, including in humans. The toxicity of heavy metals is well known, with these substances having harmful effects on human health. In this paper, the main ways of transferring heavy metals into environmental components and their spatial distribution from sterile holes to water and soil environment components. As a case study, the sterile Balomir hole, an inactive hole for about 9 years resulting from the exploitation of the hule from the Uricani mine located in the Jiu Valley.
Diagnosing the Issue: Understanding and Combating Medical Brain Drain in Bosnia and Herzegovina
Authors: Jahić Hatidža , Hadžiahmetović-Milišić Nejra , Dedović Lejla , Kuloglija Emina
Published: July 2024

This study investigates emigration patterns among healthcare professionals in Bosnia and Herzegovina, examining the underlying reasons for emigration and proposing actionable solutions to curb this trend. A mixed-methods approach is employed, combining quantitative data from surveys administered to medical and health studies students with qualitative insights from interviews with governmental officials, language educators, and statistical agencies. The findings reveal significant dissatisfaction with socio-economic and political conditions, prompting healthcare professionals to seek opportunities abroad. Major reasons for going abroad include political instability, low wages, and poor working conditions, while better pay and career opportunities are attracting factors. While the study is limited by the lack of comprehensive official statistics on emigration, the implications of this research emphasize the need for policy interventions aiming to improve local working conditions and reform educational systems. The study provides valuable insights for policymakers and stakeholders to effectively address the issue of brain drain.