bluuebunny/crossref_metadata_2025 huggingface dataset:
OXIDATIVE MODIFICATION OF PROTEINS IN COLORECTAL CANCER UNDER THE INFLUENCE OF 5-FLUOROURACIL AND MOLECULAR HYDROGEN
Authors: Pokotylo O.O. , Korda M.M.
Published: August 2024

The aim of the study – to investigate the effect of water saturated with molecular hydrogenand 5-fluorouracil on the content of carbonyl groups of oxidatively modified proteins inthe blood serum of white rats with colorectal cancer.Material and Methods. The experiments were conducted on 50 male Wistar rats. Theanimals were modeled with colorectal cancer (CRC) by subcutaneous injection of1,2-dimethylhydrazine (DMH) at a dose of 7.2 mg/kg body weight once a week for 30weeks. 5-Fluorouracil was administered intraperitoneally for 4 days at 12 mg/kg andfor another 4 days every other day at 6 mg/kg. Animals consumed water enriched withmolecular hydrogen at a concentration of 0.6 ppm ad libitum. Rats were euthanizedunder thiopental anesthesia. Blood serum was used for the study, in which the content ofcarbonyl groups was determined by the colorimetric method. Statistical data processingwas performed using the SPSS-22 software package.Results. It was found that the modeling of colorectal cancer led to a 1.77-fold increase inthe content of carbonyl groups in the blood serum of rats compared to intact animals. Thecontent of carbonyl groups in the blood serum of rats with CRC treated with chemotherapyby administration of 5-fluorouracil increased 1.93 times compared to the intact groupand 1.1 times compared to animals with CRC. Consumption of water saturated withmolecular hydrogen 30 days after modeling CRC and administration of 5-fluorouracilto white rats led to a 1.18-fold decrease in the content of carbonyl groups in their bloodserum compared to animals with CRC who were administered 5-fluorouracil but did notconsume water saturated with molecular hydrogen.Conclusions. The use of molecular hydrogen saturated water is an effective methodof reducing oxidative modification of proteins in rats with colorectal cancer under5-fluorouracil chemotherapy.
LAPAROSCOPIC DIAGNOSIS OF ENDOMETRIOSIS-ASSOCIATED INFERTILITY
Authors: Yuzko O.M. , Tofan B.Y.
Published: August 2024

The purpose of the study – to generalize the laparoscopic manifestations of genital andextragenital endometriosis in women with infertility, followed by the determination of itsbelonging to international classifications of pathology for the possibility of choosing fullfledged methods of influencing the focus of the disease.Materials and methods. The study was conducted in two stages: a detailed analysis ofscientific studies on the issue of classification of endometriosis R-AFS, Enzian, EFI witha generalization of the main search criteria during laparoscopy; a study based on themedical center «Yuzko» in Chernivtsi, in which 42 women who contacted about infertilitytook part. In the practical part of the work, clinical and paraclinical methods of diagnosis,laparoscopic revision were used, followed by the formation of diagnoses according to themain classifiers of endometriosis, determination of the fertility index and generalizationof the form of endometriosis as a cause of infertility.Research results. Endometriosis is a chronic pathology of the female reproductive system,which often leads to infertility and is accompanied by various clinical manifestations inthe form of pain and menstrual dysfunction. For the purpose of a complete diagnosis ina specific case, an important stage is the determination of the depth and stage of developmentof the endometrioid focus based on the results of laparoscopy according to the classificationproposed by the American Fertility Society (R-AFS classification), Enzian, followed bythe determination of the fertility index (EFI) in order to choose individual managementtactics of each patient. A study was conducted at Yuzko Medical Center, in which 42 womenof various ages who complained of infertility took part. In the course of laparoscopicoperations, various methods of removing endometrioid foci were implemented depending onthe specific clinical case, after which the stage of endometriosis was determined according to the Enzian, R-AFS classification, and a conclusion was formed about the directdependence of the risk of infertility and the depth of the spread of endometriosis foci.Conclusion. The stage and depth of endometriosis plays a decisive role in the developmentof female infertility, which requires careful diagnosis according to modern classificationsand the implementation of a specific treatment program with the aim of developinga natural pregnancy or successful embryo transfer during in vitro fertilization.
ASSESSMENT OF READINESS FOR DISCHARGE OF PATIENTS WITH HEART FAILURE FROM CARDIOLOGY HOSPITAL
Authors: Hryhorets D.K. , Plesh I.A.
Published: August 2024

The aim of the study – to assess the readiness for discharge of patients with heart failure (HF) from a cardiac hospital by nurses using the Readiness For Hospital Discharge Scale – Nurse Form (nurse version) and to determine indicators of self-assessment of patients with HF in a cardiac hospital using the Readiness for Hospital Discharge Study Form – Adult Form (patient self-report) according to the Readiness for Hospital Discharge Scale. Materials and methods. The survey involved 50 patients with HF II-A and II-B stages according to Vasylenko- Stazhesko and II-IV functional classes according to NIHA, aged 30-85 years, and 10 nurses of the general cardiology department No. 1 of «Chernivtsi Cardiology Center». Results. 72.0 % of patients were ready for discharge. 28.0 % of respondents had low physical stability and emotional readiness on the day of discharge, while 68.0 % were characterized by a moderate level. At the time of the survey, 64.0 % of patients showed low knowledge of self-care at home and the ability to overcome difficulties – 46.0 %. There are differences between the responses of nurses and patients in the assessment items of personal status at the time of discharge and the quality of knowledge obtained at discharge related to overcoming difficulties at home. According to nurses’ assessment, 81.5 % of patients had a moderate physical and emotional level of readiness for discharge. Only 38.2 % of patients had low knowledge about taking medications and restrictions after returning home. Nurse-rated scores are moderately correlated with patients’ self-rated readiness for discharge and are a stronger predictor of readmission risk than patient self-rated.
 
Conclusions. The results obtained indicate a satisfactory level of self-preparedness and a moderate level in terms of nurse assessment before discharge of patients with HF in a cardiac hospital.
Pengaruh Tayangan Konten Review Film pada Channel Youtube Cine Crib Terhadap Keputusan Menonton Subscribers
Authors: Akbar Ilham , Suyanto Suyanto , Ismandianto Ismandianto , Awza Rusmadi
Published: August 2024

Cine Crib is a youtube channels that focuses on the most popular movie review content in Indonesia. Through his Youtube channel, Cine Crib consistently uploads film review videos and has gained 239,000 subscribers. The Cine Crib film review videos has the potential to influence the decision of Cine Crib subscribers to watch the reviewed film. Therefore, this study aims to see the influence of film review content on the Cine Crib youtube channel for the subscriber's watching decision with quantitative research method in an explanation format. Through the slovin formula, 400 respondents were obtained who are subscribers of Cine Crib using simple random sampling as sampling technique. After the questionnaire was gathered via google form, thedata found were then processed using SPSS for windows version 25 with simple linear regression analysis as a data analysis technique. The results of this study indicate that there was an influence of film review content on the Cine Crib youtube channel on the subscriber's watching decision by 34% who fell into the weak category, and the rest were influenced by other variables that were not included in this study by 66%. With these results, it can be concluded that the impression of Cine Crib's film review content does have an influence on her subscribers, but the influence exerted tends to be weak and the impression of review content on Cine Crib's Youtube channel is not the only variable that affects her subscribers' viewing decisions.
KONTRIBUSI LATIHAN WALL VOLLEY DAN LATIHAN SQUAD TERHADAP KEMAMPUAN PASSING BAWAH BOLA VOLI KLUB AKRAL KABUPATEN DELI SERDANG
Authors: Siahaan Richardo Pattun , Hardinoto Nono
Published: August 2024

Penelitian ini bertujuan untuk mengetahui kontribusi latihan wall volley dan latihan squat terhadap kemampuan passing bawah bola voli. Metode penelitian yang digunakan yaitu eksperimen dan desain pre-eksperimental tipe one group pretest-posttest. Adapun populasi berasal dari atlet klub bola voli akral Kabupaten Deli Serdang berjumlah 50 orang, dengan menggunakan teknik purposive sampling diperoleh 10 orang sampel. Penelitian ini dilakukan selama 6 minggu. Data hasil analisis hipotesis pertama dengan menggunakan uji regresi diperoleh = 52,08 dan = 5.32, maka diperoleh > . Analisis hipotesis kedua menggunakan uji regresi sederhana diperoleh =10,97 dan , maka diperoleh > . Hipotesis ketiga dengan uji regresi berganda diperoleh  =33,32 dan , maka diperoleh > .  Maka diperoleh kesimpulan hasil penelitian bahwa (1) terdapat kontribusi yang signifikan dari latihan wall volley terhadap kemampuan passing bawah bola voli klub Akral Kabupaten Deli Serdang sebesar 87,93%, (2) terdapat kontribusi yang signifikan dari latihan squat terhadap kemampuan passing bawah bola voli klub Akral Kabupaten Deli Serdang sebesar 89,23%, (3) terdapat kontribusi yang signifikan dari latihan wall volley dan latihan squat terhadap kemampuan passing bawah bola voli klub Akral Kabupaten Deli Serdang sebesar 81%.
DAMPAK ANALISIS PEKERJAAN TERDAHAP MANAJERIAL GENERASI BARU INDONESIA SUMATERA UTARA DALAM MENINGKATKAN KUALITAS KINERJA
Authors: Armayanti Nelly , Nurhasanah Ayu , Pratami Dinda
Published: August 2024

Metode pengumpulan data yang digunakan dalam penelitian ini adalah menggunakan metode kuesioner. Peneliti menggunakan 3 responden sebagai sampel. Proses penyebaran kuesioner dilakukan dengan memberikan kuesioner 11 terhadap responden yang menjabat sebagai anggota BPH GenBI SUMUT secara online melalui google from dengan menggunakan teknik Self-Administered Questionnaires. Tujuan penelitian ini untuk bagaimana dampak analisis pekerjaan dan peran manajerial terhadap peningkatan kualitas kinerja. Teknik penentuan sampel yang dilakukan dalam penelitian ini bersifat tidak acak (non-random sampling) yaitu dengan menggunakan teknik Purposive Sampling. Berdasarkan hasil angket yang telah disebar juga didapat informasi bahwa uraian jabatan dan spesifikasi jabatan pada organisasi GenBI Sumatera Utara sudah berjalan sesuai dengan harapan, dan sesuai dengan perencanaan yang telah ditetapkan.
ANALISIS KINERJA KARYAWAN PADA LEMBAGA ADMINISTRASI NEGARA
Authors: Tsany Raihan
Published: August 2024

Penelitian ini bertujuan untuk mengetahui kinerja karyawan di Lembaga AdministrasiNegara. Penelitian ini menggunakan desain penelitian literatur review melalui pendekatankualitatif. Selama proses mengumpulkan data peneliti menggunakan teknik purposivesampling dimana pengumpulan data ini dilakukan melalui pengisian kuesioner, wawancaradan observasi. Teknik analisis yang digunakan adalah dengan pengumpulan data, reduksidata, penyajian data dan penarikan kesimpulan. Berdasarkan hasil penelitian menunjukanbahwa kinerja karyawan pada Lembaga Administrasi Negara sudah cukup baik dalam halmenyelesaikan pekerjaan masing-masing.
MANFAAT LATIHAN AEROBIK DAN LATIHAN TAHANAN TERHADAP FUNGSI KOGNITIF LANJUT USIA: LITERATUR REVIEW
Authors: Fandrian Ganang , Muhammad Akbar Bota , Afifa Zulaika Nur , Yudistira Efraldo , Siddiq Toumi , Ardiaviandaru Siamy Hapy
Published: August 2024

ABSTRAK
Latar Belakang. Neurodegenerative merupakan kondisi yang lazim di jumpai pada populasi lansia. Banyak penelitian menunjukkan efek positif latihan fisik dalam menunda atau mencegah kondisi tersebut. Latihan aerobik yang terstruktur melibatkan anggota gerakan atas dan menyilangkan ekstremitas untuk merangsang kedua belahan otak. Latihan tahanan adalah bentuk latihan yang ditujukan untuk menghasilkan peningkatan serat otot dan sinkronisasi yang lebih kuat, yang pada akhirnya meningkatkan kontrol neuromuskular dan mengarah pada pertumbuhan otot. Bahan dan Metode. Metode penelitian yang di terapkan merupakan studi tinjauan literatur. Pencarian data menggunakan kata kunci dan Boolean operator yang dilakukan melalui artificial intelligence (AI): Publish and Pearish. Basis Data di ambil dari beberapa penerbit jurnal ilmiah yang terdapat dalam mesin pencarian Jurnal Ilmiah, seperti: Crossref, Pubmed, Scopus, Google Scholar. Setelah dilakukan penyaringan artikel didapatkan 8 artikel untuk dilakukan peninjauan. Artikel dimasukkan dalam review setelah membaca artikel full-text. Pendekatan sederhana dan tematik digunakan untuk sintesis data. Tujuan. Studi ini bertujuan untuk mengevaluasi mengenai efek latihan aerobik dan latihan tahanan terhadap fungsi kognitif pada lanjut usia. Hasil. menunjukan literatur yang cukup memuaskan berupa terjadinya peningkatan fungsi kognitif pada Lansia baik secara klinis maupun secara biomarker. Kesimpulan. Diduga, peningkatan kognisi di dapatkan akibat dari perbaikan vaskularisasi umum pada tubuh, yang mendorong jumlah nutrisi dan oksigenasi otak ikut meningkat.
Ornamental Variety of Tombs of Sigam Kings in 1855-1900 in the Wetland Area of Sigam Sea Island, Kotabaru Regency
Authors: Yahya Daud , Efendi Rusdi
Published: August 2024

History and culture have begun to be fulfilled by the younger generation, it takes effort to map history and concrete explanatory evidence of each heritage site from the past. Kotabaru Regency is one of the centers of study of this research because many historical relics were found in the form of tombs from the Sigam Kingdom that received less attention from related agencies. Therefore, deeper research is needed so that it can be an evaluation material for future policies and strategies. This study aims to find out how the shape of the tomb (typology) and the variety of ornamental tombs of the kings of Sigam in 1855-1900. The research method uses historical methods: (1) heuristics, (2) source criticism, (3) interpretation, (4) historiography. The results of this study are as follows: This cemetery is a complex of tombs of kings, Kingdoms, Sea Island and their relatives. The King of Pulau Laut who is buried in this complex there are three people, namely Prince Jaya Sumitra bin Pangeran Muhammad Nafis, Prince Abdul Kadir bin Pangeran Muhammad Nafis, and Pangeran Brangta Kesuma bin Pangeran Abdul Kadir. The tombstones of the kings are currently covered in yellow cloth by the surrounding community.
Use of Quizizz Learning Media at MAN 1 Banjarmasin
Authors: Purnamasari Reski , Sumiati Sumiati
Published: August 2024

Quizziz is one of the learning media that creates a learning experience for students. There are features in Quizizz that can be used in learning. This study aims to determine the use of Quizizz  learning media in MAN 1 Banjarmasin students in class X and XI IPS MAN 1 Banjarmasin for the 2022/2023 academic year. The method used in this study is quantitative method. The research population of class X and XI IPS MAN 1 Banjarmasin students amounted to 190 students and the sample amounted to 47 students. Data collection by questionnaire. Analysis of research results with SPSS 25 for Windows.  The results showed that the use of Quizizz learning media in MAN 1 Banjarmasin in grade X and XI IPS in MAN 1 Banjarmasin for the 2022/2023 academic year against 47 students as respondents: Very low (0%), low (2.13%), medium (19.15%), high (31.91%) and very high (46.81%). So based on these results, the use of Quizizz learning media  for MAN 1 Banjarmasin class X and XI IPS for the 2022/2023 school year is at a very high level (46.81%).
Optimising social evolution through creating welfare and product innovation of Micro Waqf Bank in Indonesia
Authors: Fauzi Muhamad , Widana IGN Oka , Dahlan Rahmat , Muhammedi Ssonko
Published: August 2024

Micro Waqf Banks are a form of innovation of Islamic social and financial institutions by the government to provide access to business expansion and the welfare of the productive poor around Islamic boarding schools. Optimising product innovation for Micro Waqf Bank customers requires changes in micro-business actors to improve their welfare sustainably. This study analyses the product innovation of Micro Waqf Bank customers with a social evolution model approach. The qualitative method used a grounded theory approach. They collect data through observations, interviews, documentation, and literature studies—design thinking analysis with triangulation techniques. The results found that the welfare of Micro Waqf Bank customers was created for the community around Islamic boarding schools by optimising product innovation through the involvement of the Indonesian Ulama Council and government participation in product certification bodies. The study uses a design thinking approach for formulating solutions to increase Micro Waqf Bank customers' product innovation in creating their welfare by Micro Waqf Bank optimising halal labelling, intellectual property rights-protected brands, attractive packaging, and product consumption feasibility. The social evolution model's research implication is recommendations for optimising innovative products and creating welfare.
A Framework for Risk Mitigation in Halal Self-Declaration for SMEs and MSMEs in Indonesia
Authors: Putera Perdana Firdaus Fanny , Habir Ahmad D.
Published: August 2024

This research examines the challenges and risk mitigation strategies associated with Halal self-declaration among Small and Medium-sized Enterprises (SMEs) and Micro, Small, and Medium-sized Enterprises (MSMEs) in the context of the forthcoming Halal certification enforcement policy in Indonesia. The study aims to enable SMEs and MSMEs to actively participate in the Halal industry, with the intent to promote economic inclusivity and ensure the accuracy, integrity, and reputation of Halal products. The research explores potential consequences such as mislabeling, cross-contamination, reputational damage, legal repercussions, negative market impact, and erosion of Halal industry credibility. In this research, a structured thematic analysis approach is conducted. The findings of the study propose risk mitigation strategies, including risk identification, framework development, education programs, accessible guidance materials, the implementation of independent verification and audits collaboration with certification bodies and regulatory agencies, awareness campaigns, and continuous improvement and evaluation. The outcomes of this research benefit SMEs, MSMEs, certification bodies, industry associations, regulatory agencies, and consumers, enhancing compliance with Halal standards, consumer confidence, and market competitiveness.
PASAR DIGITAL SYARIAH DALAM TRANSAKSI BISNIS MODERN
Authors: Muhammad Mahmuda Mulia
Published: August 2024

Abstrak
Digitalisasi ekonomi syariah dapat merambah dalam berbagai aspek ekonomi baik ekonomi mikro maupun ekonomi makro. Sekarang ini peran digital sangat luar biasa, hampir semua perekonomian menggunakan teknologi informasi dan komunikasi atau digitalisasi. Ekonomi syariah sebagai suatu pemikiran ekonomi yang dianggap dapat menjadi alternatif dari pemikiran ekonomi saat ini sedang berkembang pesat di seluruh dunia dalam 10 tahun terakhir. Oleh karena itu dibutuhkan pelaku ekonomi yang mengedepankan hukum Islam dalam transaksinya, dalam hal ini dibutuhkan adalah menghindari praktik riba menuju falah, memaksimalkan laba dan keterlibatan pemerintah sebagai stakeholder. Dengan demikian, akan melahirkan pasar ekonomi digital syariah yang selama ini diidam-idamkan.
Kata kunci: Digitalisasi, Ekonomi Syariah, Bisnis Online
 
Abstract
The digitalization of the Islamic economy can penetrate various economic aspects, both micro and macroeconomics. Today the role of digital is extraordinary, almost all economies use information and communication technology or digitization. Islamic economics as an economic thought that is considered to be an alternative to economic thought is currently growing rapidly throughout the world in the last 10 years. Therefore, it is necessary for economic actors who prioritize Islamic law in their transactions, in this case what is needed is to avoid the practice of usury towards falah, maximize profits and involve the government as a stakeholder. Thus, it will give birth to the sharia digital economy market that has been coveted.
Keywords: Digitalization, Islamic Economy, Online Business.
TINJAUAN HUKUM ISLAM TERHADAP BIAYA TAMBAHAN ATAS KETERLAMBATAN PENGEMBALIAN PADA SEWA MENYEWA KAMERA
Authors: H Muhajir , Suriyadi
Published: August 2024

Abstrak
Salah satu ruang lingkup fikih muamalah adalah pembahasan tentang perikatan dan perjanjian. Dalam melakukan perjanjian harus dilakukan dengan cara kesepakatan atas dasar kerelaan antara kedua belah pihak, sehingga tidak ada yang merasa terpaksa. Pokok permasalahan pada penelitian ini adalah bagaimana pandangan hukum Islam tentang biaya tambahan atas keterlambatan pengembalian pada sewa menyewa kamera pada SR Motret. Jenis penelitian ini adalah penelitian lapangan (field research) menggunakan metode kualitatif dengan pendekatan penelitian yang digunakan adalah teologi normative (syar’i), yuridis dan empiris. Berdasarkan hasil penelitian ini menunjukkan bahwa bentuk transaksi sewa menyewa pada SR Motret dilakukan secara tertulis dan mempunyai beberapa syarat, dimana pihak penyewa harus terlebih dahulu melengkapi persyaratan yang telah ditentukan oleh pihak SR Motret sebelum bisa mengambil barang berupa kamera untuk disewa. Syaratnya berupa menyerahkan kartu identitas, jaminan dan nomor handphone yang bisa dihubungi. Sedangkan Dalam Fikih Muamalah praktik penerapan denda dalam sewa-menyewa kamera di SR Motret diperbolehkan, sebab boleh menarik denda keterlambatan kepada pihak penyewa yang mampu mengembalikan kamera tepat waktu tetapi menunda-nundanya.
Kata Kunci: Biaya Tambahan, Hukum Islam, Sewa Menyewa
 
Abstract
One of the scopes of muamalah fiqh is the discussion of engagements and agreements. In making an agreement, it must be done by means of an agreement on the basis of the willingness of both parties, so that no one feels forced. The main problem in this study is how Islamic law views the additional costs for late returns on renting a camera at SR Motret. This type of research is field research using qualitative methods with the research approach used is normative theology, juridical and empirical. Based on the results of this study, it shows that the form of the rental transaction at SR Motret is done in writing and has several conditions, where the tenant must first complete the requirements that have been determined by the SR Motret before being able to take goods in the form of  camera for rent. The conditions are to submit an identity card, guarantee and a cellphone number that can be contacted. Whereas in Fiqh Muamalah, the practice of applying fines in renting cameras at SR Motret is allowed, because it is permissible to withdraw late fees to the tenant who is able to return the camera on time but delays it.
Keywords: Islamic Law, Rent Rent, Surcharge.
Implementasi Program Pemajuan Kebudayaan Desa: Tinjauan Pemberdayaan Masyarakat Berbasis Budaya
Authors: Wulandari Desy
Published: August 2024

Penelitian ini bertujuan untuk mengetahui efektivitas implementasi program Pemajuan Kebudayaan Desa (PKD) dalam upaya melindungi budaya tradisional dan memberikan ruang kepada komunitas untuk mengembangkan serta mengekspresikan budayanya. Penelitian ini menggunakan pendekatan kualitatif dengan dukungan data-data kuantitatif. Pengumpulan data dilakukan melalui kuesioner daring yang ditujukan kepada individu lokal desa yang terpilih sebagai fasilitator Program PKD atau Pendamping Kebudayaan Desa. Data dianalisis secara deskriptif dengan mengidentifikasi tema yang muncul dari respons kuesioner. Hasil penelitian menunjukkan implementasi Program PKD mendorong pemerintah desa dan masyarakatnya memahami potensi budaya mereka sehingga meningkatkan kepedulian terhadap pelestarian budaya. Program PKD juga memberi andil terhadap pembentukan ruang ekspresi budaya dan kerja sama antardesa pada sektor kebudayaan yang berkontribusi pada kesejahteraan masyarakat. Kesimpulan, program PKD merupakan salah satu program pemberdayaan masyarakat berbasis budaya yang efektif meningkatkan kesadaran pemerintah dan masyarakat desa akan pentingnya upaya perlindungan dan pelestarian kebudayaan yang memiliki andil dalam kamajuan bangsa.
Diagnostic accuracy of intraoperative touch imprint cytology and frozen sections for the evaluation of margin status and diagnosis of oro-pharyngeal squamous cell carcinomas
Authors: Salahuddin Hamna , Sharif Sadia , Kaleemi Shizra , Babar Kanwal , Zaheer Abeer , Anwar Sadia
Published: August 2024

Background and Objective: In surgical procedures, accurate intraoperative diagnosis is essential for guiding surgical management. Two common techniques employed for rapid intraoperative diagnosis are touch imprint cytology (TIC) and frozen section (FS). However, their diagnostic accuracy as compared to histopathology remains under debate. This study therefore aims to evaluate the diagnostic precision of FSs and TIC taking histopathology as a gold standard in oropharyngeal squamous cell carcinoma (OPSCC) biopsies.

Methods: A total of 122 biopsies of OPSCC were received for FS analysis at the Histopathology Department of the University College of Medicine and Dentistry Lahore, Pakistan. Touch imprints were taken from the surgical margins of the same biopsies and FSs were cut and stained with rapid Hematoxylin and Eosin stain following standard protocols. Paraffin-embedded histopathology sections were later made from the same tissues for comparison and diagnostic accuracy studies.

Results: Comparison of FS with histopathology showed a sensitivity of 60%, specificity of 100%, positive predictive value (PPV) of 100%, negative predictive value (NPV) of 95%, and overall diagnostic accuracy of 95%. On comparison of TIC with histopathology, sensitivity was 86.6%, specificity was 100%, PPV was 100%, NPV was 98.2%, and accuracy was 98.3%.

Conclusion: In comparison to histopathology, TIC and FS examination have promising utility as well as certain limitations for the evaluation of the margin status of OPSCC specimens. Thus, with careful consideration, these techniques may provide valuable insights for clinical practice in local settings with both time and cost-effective approaches.
Assessment of knowledge and utilization of electrocardiogram by primary health care physicians and nurses in Qassim Region, Saudi Arabia
Authors: Alsubaie Abdulrahman , Yahia Omer
Published: August 2024

Objective: This study aimed to assess primary care physicians' and nurses' knowledge and utilization of electrocardiograms (ECGs) in primary health care centers (PHCCs) in Qassim, Saudi Arabia.
Methods: A cross-sectional study was conducted among PHCC physicians and nurses in Qassim Region, Saudia Arabia. An online self-administered questionnaire was used to obtain information about the knowledge and use of ECG.
Results: A total of 320 physicians, family medicine residents, and nurses participated in the survey. Out of the participants, 174 (54.4%) were females. The majority (n = 130, 40.6%) were aged between 31 and 40 years. In terms of the number of ECGs requested per week, approximately half of the participants, 158 (49.4%), requested ECGs two to five times per week. The most common reason for ECG requests was angina at 279 (87.2%), followed by arrhythmia at 139 (66.3%) and hypertension at 80 (25.0%). A majority of the doctors (56.3%) reported receiving ECG interpretation from senior colleagues. The most common ECG diagnosis reported was normal ECG among 296 (92.5%). Furthermore, 114 (35.6%) of the participants stated that they believed bedside teaching was the most effective way to improve ECG knowledge and its practical use.
Conclusion: This study revealed that primary care physicians and nurses in Qassim, Saudi Arabia, had a limited understanding of and limited use for ECGs. It is strongly recommended to provide bedside training, hands-on tutorials during clinical rotations, and workshops/continuous medical education (CME) to enhance ECG knowledge, attitude, and utilization.
Pengaruh asupan protein terhadap kualitas tidur pegawai bank
Authors: Greinardo Brian Ezra , Silaban Dorna Yanti Lola
Published: August 2024

Kualitas tidur penting untuk kesehatan dan kualitas hidup setiap orang. Seseorang dengan kualitas tidur yang buruk dapat mengalami stres, penurunan kognitif, kelelahan, gangguan kognitif, dan depresi. Sebaliknya, stres dan depresi  dapat menurunkan kualitas  tidur. Salah satu faktor yang menjaga kualitas tidur adalah serotonin yang dibuat oleh asam amino triptofan. Studi ini bertujuan untuk mengetahui hubungan asupan protein dengan kualitas tidur seseorang. Metode studi yang digunakan ialah analitik observasional dengan pendekatan cross-sectional yang telah diizinkan dan disetujui oleh kantor OCBC NISP Jakarta sebagai tempat pengambilan sampel dan komite etik penelitian Universitas Tarumanagara. Besar sampel studi ini ialah 152 orang yang diambil dengan teknik consecutive sampling. Data karakteristik, asupan protein dan kualitas tidur responden penelitian dikumpulkan masing-masing menggunakan lembar kuesioner identitas, semi quantitative food frequency questionnaire (SQ-FFQ) dan Pittsburgh Sleep Quality Index (PSQI). Hasil studi didapatkan 61,3% orang dengan asupan protein kurang-cukup memiliki kualitas tidur buruk dan 66,7% orang dengan asupan protein lebih juga memiliki kualitas tidur buruk (p-value = 0,576). Kesimpulan studi ini menunjukkan bahwa tidak ada hubungan antara asupan protein dengan kualitas tidur pada pegawai Bank OCBC NISP Jakarta.
Pengaruh status gizi terhadap tingkat hipertensi pada populasi dewasa di Kelurahan Tomang Jakarta Barat
Authors: Huang Daniel , Santoso Alexander Halim
Published: August 2024

Tekanan darah tinggi atau hipertensi memiliki konsekuensi yang signifikan dan dapat fatal karena sering tidak memiliki gejala pada penderita. Peningkatan hipertensi di dunia juga sejalan dengan peningkatan obesitas. Studi ini bertujuan untuk mengetahui bagaimana status gizi berdampak pada hipertensi pada orang dewasa di Jakarta Barat. Studi analitik ini menggunakan desain cross-sectional terhadap 98 subjek di Kelurahan Tomang. Pengambilan subjek studi menggunakan teknik non-probability sampling. Data yang diambil meliputi indeks massa tubuh dengan mengukur tinggi badan (microtoise), berat badan (timbangan berat digital), dan tekanan darah (sphygmomanometer). Selain itu, data-data terkait biodata, riwayat keluarga, kebiasaan seperti merokok, aktivitas fisik, dan konsumsi alkohol ditanyakan melalui kuesioner. Hasil studi didapatkan 56 (57,1%) subjek memiliki status gizi berlebih dan 42 (42,9%) subjek dengan status gizi normal. Selain itu, 42 (42,9%) subjek dengan hipertensi dan 56 (57,1%) subjek dengan tidak hipertensi. Hasil studi juga memperlihatkan dari 42 subjek yang memiliki IMT normal, 33 (78,6%) subjek diantaranya tidak mengalami hipertensi. Sebanyak 23 (41,1%) subjek dari 56 subjek dengan status gizi berlebih, tidak mengalami hipertensi.  Pada uji statistik, didapatkan  hubungan yang bermakna antara indeks massa tubuh dengan kejadian hipertensi dengan nilai p 0,0002 dan nilai prevalence risk ratio (PRR) didapatkan 2,75 yang berarti status gizi berlebih merupakan faktor risiko terjadinya peningkatan tekanan darah.
Analisis persepsi persiapan masa tua terkait impecunity pada lansia di panti wreda
Authors: Sui Christopher Bryan , Wati Djung Lilya
Published: August 2024

Masyarakat usia produktif akan memasuki kelompok umur lansia dengan seiringnya berjalannya waktu. Mereka akan berhenti bekerja, baik karena memasuki usia pensiun maupun karena alasan kesehatan. Kondisi tersebut akan mempengaruhi ekonomi mereka. Jika mereka tidak menyiapkan masa tua secara baik, maka dapat berpotensi mengalami kemiskinan/impecunity sehingga kesulitan dalam memenuhi kebutuhan dengan keuangannya sendiri. Terlebih lagi pada lansia yang bertempat tinggal di panti karena mereka harus membayar panti. Penelitian ini bertujuan untuk mengetahui hubungan antara persepsi lansia dalam mempersiapkan masa tua dengan terjadinya impecunity saat ini pada lansia di Panti Sasana Tresna Werda RIA Pembangunan, Cibubur, Jakarta Timur; Panti Werda Hana, Banten; dan Panti Werda Wisma Mulia, Jelambar, Jakarta Barat. Penelitian analitik ini menggunakan desain cohort retrospective dan mengumpulkan 71 jumlah sampel lansia. Variabel yang diteliti terdiri dari data pengeluaran, persiapan masa tua, dan persepsi kecukupan masa tua. Pengumpulan data menggunakan teknik non-randomized consecutive sampling dan dianalisis secara statistik menggunakan uji chi square. Studi ini menemukan sebanyak 56 (78,9%) lansia yang mengalami sindrom geriatri impecunity dengan 33 lansia tidak memiliki persiapan masa tua (p-value = <0,001; PR = 1,65; CI 95% = 0,468-0,782). Penelitian ini menemukan adanya hubungan antara persepsi lansia dalam mempersiapkan masa tua dengan terjadinya impecunity.
Hubungan efikasi diri dengan self-directed learning readiness mahasiswa kedokteran Universitas Tarumanagara angkatan 2021
Authors: Darajat Salsa Aulia , Tjandra Oentarini
Published: August 2024

Self-Directed Learning, proses mahasiswa berinisiatif untuk merancang pembelajaran dimulai dari menentukan strategi hingga mengevaluasi hasil pembelajarannya, dibutuhkan mahasiswa kedokteran untuk menerapkan belajar sepanjang hayat agar setelah menjadi dokter mereka dapat mengembangkan kompetensinya dengan selalu memperbarui pengetahuan seiring dengan kemajuan teknologi dan informasi di bidang medis. Tingkat SDL seseorang dapat diukur menggunakan Self-Directed Learning Readiness (SDLR). Faktor yang dapat memengaruhi SDLR antara lain efikasi diri. Efikasi diri merupakan keyakinan seseorang terhadap kemampuan yang dimiliki untuk bertindak dan mengatur hal yang diperlukan dalam mencapai suatu pencapaian. Efikasi diri dapat memengaruhi usaha, ketekunan, dan pencapaian seseorang dalam belajar. Studi ini bertujuan untuk mengetahui hubungan antara efikasi diri dengan tingkat SDLR pada mahasiswa Fakultas Kedokteran Universitas Tarumanagara angkatan 2021. Studi ini menggunakan pendekatan analitik observasional dengan studi potong lintang. Sebanyak 132 responden mengisi kuesioner General Self Eficacy Scale (GSES) dan Self-Directed Learning Readiness Scale (SDLRS). Hasil studi menunjukkan 65 (49,2%) responden memiliki efikasi dan SDLR sedang, 42 (31,8%) responden memiliki efikasi sedang dan SDLR tinggi, dan sisanya 25 (18,9%) responden memiliki efikasi diri dan SDLR tinggi. Studi ini menujukkan signifikansi antara efikasi diri dengan SDLR (p-value=0,000; PR=2,548).
Gambaran tingkat pengetahuan mahasiswa kedokteran Universitas Tarumanagara angkatan 2021 pada penanganan awal tersedak
Authors: Putra Robby Tri Juleo , Malik Rebekah
Published: August 2024

Tersedak merupakan kejadian kedaruratan yang sering terjadi, umumnya disebabkan oleh makanan atau benda asing lainnya. Umumnya, keadaan ini terjadi ketika berbicara atau tertawa saat sedang makan.  Mahasiswa kedokteran harus memiliki pengetahuan yang cukup terhadap teknik penanganan awal korban tersedak. Tujuan studi ini untuk mengetahui gambaran pengetahuan pada mahasiswa kedokteran terkait penanganan awal korban tersedak. Studi yang dilakukan bersifat deskriptif potong lintang terhadap 119 mahasiswa kedokteran Universitas Tarumanagara angkatan 2021. Pengambilan data melalui kuesioner yang berisi 18 pertanyaan terkait penangan awal korban tersedak. Hasil Tingkat pengetahuan dibagi menjadi tingkat pengetahuan yang “kurang” jika hasil total ≤50%, tingkat pengetahuan yang “cukup” jika >50% hingga <75% dan “baik” jika ≥75%. Pengetahuan mahasiswa kedokteran angkatan 2021 mengenai pertolongan pertama pada pasien tersedak tergolong memiliki tingkat pengetahuan yang “cukup” (73 responden; 61,3%). Sebagian kecil tergolong tingkat pengetahuan yang  “kurang” dalam penanganan pertama korban tersedak, yaitu sebanyak 46 (38,7%) responden dan tidak ada yang memiliki tingkat pengetahuan yang “baik”.  Berdasarkan hasil tersebut, sebaiknya mahasiswa kedokteran diberikan edukasi terkait penangan tersedak dengan tujuan memberikan pertolongan pertama pada siapapun yang membutuhkan karena merupakan keadaan kedaruratan  dan terdapat perbedaan teknik pada bayi, orang dewasa, ibu hamil dan obesitas.
Marketing Margin and Value of Farmer's Share on Rendang Product In Payakumbuh City
Authors: Winda Sartika  , Budi Hartono  , Hari Dwi Utami  , Lilik Eka Radiati
Published: August 2024

Rendang products can provide a considerable contribution to each marketing institution involved. The study aims to analyze the value of and marketing margin and farmer's share for producers of the beef-based rendang industry in Payakumbuh City. The research was conducted in 2022 in the central area of the rendang industry in West Sumatra, namely Payakumbuh City. The study involved twelve rendang industries that produce rendang using beef. Data were analyzed using the marketing margin and farmer's share (Fs) formulas to determine the value received by each marketing margin and the share received by rendang producers. The result showed that the average value of marketing margin based on the number of rendang variants produced (one variant, two variants, and three variants) showed that three rendang variants produced were able to provide the highest marketing margin value of 75.21%, compared to marketing margin of two rendang variants (72.85%), and one rendang variant (59.18%). Meanwhile, marketing margins based on the type of rendang variants produced are rendang sliced (74.41%), rendang suir (75.26%), and rendang tumbuak (73.48%) with Fs value by sequentially are 13.76%, 14.28%, and 13.58%.
Prediction of PFOA and PFOS Toxicity through Log P and Number of Carbon with CompTox and Machine Learning Tools
Authors: Dashtey Ahmed , Mormile Patrick , Pedre Sandra , Valdaliso Stephany , Tang Walter
Published: August 2024

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are two major groups of PFAS will be subjected to the Maximal Contamination Concentration (MCL) of 4 ng/l in drinking water to be implemented by the U.S. EPA by 2025. How to accurately predict toxicity of PFAS with varied carbon chain length is important for treatment and sequential removal from drinking water. This study presents Quantitative Structure and Activity Relationship (QSAR) models developed through both linear regression and two order regression. Log P is compiled from reference and carbon content is counted as the molecule represented. Bioconcentration potential is predicted from CompTox.The results suggest that as log P and carbon content increase, the bioconcentration potential of PFCAs also increases. In other words, larger PFCA molecules tend to be easier to bioaccumulate in living organisms. This finding is crucial because bioconcentration refers to the accumulation of substances from water directly into living organisms through the process of passive diffusion across cell membranes. On the other hand, 96-hour fathead minnow LC50 has an inverse relationship, with higher LC50 values associated with lower log P and fewer carbons. The varying R-squared values across methods indicate differing degrees of correlation, underscoring the impact of compound structure on aquatic toxicity. Similarly, for oral rat LD50 and 48-hour D. magna LC50, the R-squared values reflect moderate to strong correlations with log P and the number of carbons. As the log P and carbon content decrease,the toxicity expressed in LC50 or LD50 increases. This relationship underscores the role of chemical properties in influencing the toxicity of PFCAs across different organisms and exposure routes. For instance, the negative correlation between log P and aquatic toxicity (96-hour fathead minnow LC50 and 48-hour D. magna LC50) suggests that compounds with higher hydrophobicity (higher log P) and more carbons may exhibit lower acute toxicity to aquatic organisms.
Encefalite límbica de origem autoimune na infância
Authors: Silva Amanda Braollos , Emidio Izaura Costa Rodrigues
Published: August 2024

Objetivo: Descrever o caso de uma paciente com suspeita de encefalite límbica de origem autoimune, a fim de alertar para uma investigação e conduta inicial do caso e, consequentemente, obter um melhor prognóstico evitando sequelas irreversíveis. Detalhamento do caso: Escolar, 7 anos e 2 meses, iniciou quadro de sintomas gripais como, febre, astenia, mialgia, odinofagia, coriza, tosse, cefaleia e dor retro orbitária. Em ambiente domiciliar, apresentou episódio de crise convulsiva e outro episódio na Unidade Básica de Saúde, sendo necessário internação na sala vermelha da Unidade de Pronto Atendimento (UPA) Pediátrica de Anápolis. Em avaliação da neurologia pediátrica, levantaram a hipótese diagnóstica de encefalite infecciosa, sendo iniciado Ceftriaxone e Aciclovir até descartada a possibilidade de infecções. Com os exames disponíveis, firmaram diagnóstico em encefalite límbica de provável etiologia autoimune, iniciando pulsoterapia com Metilprednisolona via endovenosa por 5 dias, e Imunoglobulina humana também por cinco dias, apresentando melhora clínica. Considerações finais: Diante da impossibilidade de detecção rápida de autoanticorpo, o diagnóstico e tratamento deve ser iniciado o mais rápido possível, se baseando nas manifestações clinicas e exames de imagem, como demostrado neste relato de caso, para obter melhor prognóstico e amenizar as sequelas.
Penyuluhan Urgensi Pendidikan Agama Islam Bagi Masa Depan Remaja Muslim
Authors: Ahmad M. Yusuf , Putra Ary Antony , Harahap Musaddad , Amirudin Amirudin
Published: August 2024

Dewasa ini remaja sering mengalami goncangan yang sangat luar biasa. Terutama ketika adanya media sosial. Tidak jarang para remaja kehilangan identitasnya sebagai seorang muslim. Dalam situasi demikian, tentu dibutuhkan sentuhan-sentuhan yang santun agar para remaja bisa memahami dirinya bahwa ia adalah masyarakat global dan sekaligus ia juga adalah seorang muslim. Itulah sebabnya pengabdian ini dilakukan. Metode yang dilakukan dalam pengabdian ini adalah dengan memberikan penyuluhan terhadap para remaja muslim. Untuk mengetahuai hasil dari penyuluhan, dilakukan pengamatan saat acara sampai selesai acara. Adapun hasil dari penyuluhan ini adalah terbentuknya kesadaran para remaja betapa pentingnya agama Islam sebagai bekal dalam kehidupan. Para remaja juga sudah memahami bahwa tanggungjawab pendidikan agama Islam itu tidak hanya bertumpu kepada guru di sekolah, tetapi juga oleh orangtua dan masyarakat. Sekolah, keluarga, dan masyarakat tentu harus bersinergi supaya para generasi muslim bisa dibina dengan sebaik-baiknya. Upaya-upaya penyuluhan seperti ini sangat penting untuk digalakkan agar para remaja terus mendapat pencerahan sehingga mereka tidak lalai dengan hiruk pikuk dunia. Para remaja tentu boleh untuk sibuk mencari dunia, tetapi agama Islam tetap menjadi petunjuk arah yang harus digelorakan dalam diri.
DEVELOPMENT OF VBA-EXCEL SOFTWARE PACKAGE FOR SIMULATION CHEMICAL KINETICS TASKS
Authors: Травин С. О. , Громов О. Б.
Published: August 2024

Разработан пакет программ для решения прямой и обратной задач химической кинетики. Пакет реализован в виде надстройки VBA-Excel и может быть легко интегрирован с любыми другими приложениями. Пакет включает три интегратора различной сложности, которые в совокупности позволяют моделировать динамику практически любых химико-биологических систем, включая гибридные, т.е. содержащие события, изменяющие саму структуру модели. Отличается интуитивно ясным интерфейсом и простотой использования.

Abstract - A software package has been developed for solving direct and inverse problems of chemical kinetics. The package is implemented as a VBA-Excel add-in and can be easily integrated with any other applications. The package includes three integrators of different levels of complexity, which taken together allow modeling dynamics of virtually any chemical and biological system, including hybrid ones, i.e. containing events that change the model structure itself. The package is characterized by a user-friendly interface and ease of use.
UTILIZATION OF INDUSTRIAL WASTE USING THERMAL PLASMA ENERGY
Authors: Волокитин О. Г. , Шеховцов В. В.
Published: August 2024

Рассмотрена возможность переработки техногенных силикатосодержащих отходов с использованием энергии термической плазмы с целью их дальнейшей утилизации в промышленности в качестве строительных материалов. Разработана технология, позволяющая получать из этих отходов минеральное волокно с высокими эксплуатационными характеристиками и повышенной устойчивостью к воздействию высоких температур. Предложена и апробирована конструкция плазменного реактора, позволяющего получать расплав из отходов энергетических производств и других тугоплавких неметаллических материалов, имеющих температуру плавления более 1600°С.

Abstract - A possibility is considered for thermal plasma energy-assisted processing industrial silicate-containing waste for the purpose of its further utilization in industry, i.e. in the form of construction materials. A technology has been developed that makes it possible to obtain a mineral fiber with high performance characteristics and improved resistance to high temperatures basing the above waste. Plasma chemical reactor has been designed and validated for obtaining a melt starting from various kinds of waste produced by power generating plants as well as from other refractory nonmetallic materials having melting point values exceeding 1600°C.
HIGH-TEMPERATURE SYNTHESIS OF PROTON-ELECTRON CONDUCTORS BASED ON LANTHANUM TUNGSTATE La6WO12 AND MOLYBDATE La6MoO12 FROM MECHANICALLY ACTIVATED OXIDES
Authors: Шляхтина А. В. , Щеголихин А. Н. , Колбанев И. В. , Карягина О. К. , Щербакова Л. Г.
Published: August 2024

Аннотация – Методами РФА и КР-спектроскопии исследованы вольфраматы (La6WO12, La5.5WO11.25) и молибдаты (La5.5MoO11.25, La5.8Zr0.2MoO12.1) лантана – практически важные материалы для электролитов протонпроводящих твердооксидных топливных элементов и протонпроводящих мембран. Молибдаты и вольфраматы лантана синтезированы с использованием метода механической активации оксидов с последующим отжигом при высоких температурах 1600 и 1650°C. Практически однофазные материалы La6WO12 и La5.5WO11.25  со структурой двойного флюорита были получены при 1650°C в течение 3 ч. После отжига при более низкой температуре (1600°C) материалы номинального состава La6WO12  и La5.5WO11.25 - двухфазные и содержат примесь La2O3 (~5%). Ромбоэдрические молибдаты La5.5MoO11.25 и La5.8Zr0.2MoO12.1 являются однофазными материалами в температурном интервале 1600–1650°C. Согласно смешанным КР-люминесцентным спектрам, наиболее разупорядоченными с позиции молекулярной структуры являются высокопроводящие вольфраматы лантана (La6WO12, La5.5WO11.25) , полученные при 1600 и 1650°C.

Abstract – X-ray diffraction and Raman spectroscopy study of lanthanum tungstates (La6WO12, La5.5WO11.25) and molybdates (La5.5MoO11.25, La5.8Zr0.2MoO12.1) has been performed taking into account the fact that these ceramic materials are practically important for applying as electrolytes for solid oxide fuel cells (SOFCs) and proton conducting membranes. Lanthanum molybdates and tungstates have been synthesized using a procedure for mechanical activation of oxides followed by annealing at high temperatures, i.e. 1600 and 1650°C. Substantially single-phase materials La6WO12 and La5.5WO11.25 with a double fluorite structure have been obtained at 1650°C within 3 h. The products annealed at a lower temperature (1600°C) with a nominal composition of La6WO12 and La5.5WO11.25 are characterized by two-phase structure and the presence of an admixture of La2O3 (~5%). Lanthanum molybdates La5.5MoO11.25 and La5.8Zr0.2MoO12.1 synthesized in the temperature range of 1600-1650°C are shown to have rhombohedral single-phase structure. According to mixed Raman-luminescence spectra, the high-conducting lanthanum tungstates (La6WO12, La5.5WO11.25) synthesized at 1600 and 1650°C are found to be the most disordered ones from the viewpoint of their molecular structure.