bluuebunny/crossref_metadata_2025 huggingface dataset:
Formulating evidence-based design guidelines for therapeutic gardens tailored to elderly populations: a synthesis of reminiscence and preference studies
Authors: Heród Anna , Szewczyk-Taranek Bożena , Pawłowska Bożena
Published: June 2024

Gardens emerge as powerful catalysts for enhancing the well-being of the older generation. The design of a garden plays a significant role in engagement with such an environment. The investigation aimed to determine features integral to the garden for older adults to be applied as design guidelines for therapeutic gardens serving the elderly. A mixed quantitative-qualitative approach was used with a questionnaire focused on eliciting insights into the garden experiences. The respondents comprised individuals from Care Homes and Senior Activity Centres. The results revealed the importance of childhood gardens and associated memories of the elderly. Consequently, the conceptualisation of a garden tailored to the needs of older adults highlights relaxation. A garden should facilitate passive engagement with nature and active involvement in the nurturing of plant life. Botanical preferences encompass a diverse array of flora: roses, tulips, and peonies in the floral domain; tomatoes, onions, and carrots within the vegetables; and apples, pears, and plums within the realm of fruits.
Mechanical properties of polymer fibre reinforced concrete in the light of various standards
Authors: Blazy Julia , Drobiec Łukasz , Wolka Paweł
Published: June 2024

The article presents the results of a detailed experimental campaign including a compressive strength test, three- and four-point bending test (3PBT and 4PBT, respectively) of polymer fiber reinforced concrete with the addition of metakaolin. The comprehensive analysis included three Types of concrete mixture differing in amount and used polymer fibers. It was concluded that polymer fibers did not influence the maximum compressive and flexural tensile strength of concrete. On the other hand, they had a beneficial effect on the ductility, residual and equivalent flexural tensile strengths, and fracture energy of samples. The mixtures of Type 1 and 2 were characterized by softening behaviour but the mixture of Type 3 by soft-hardening behaviour. In the 3PBT, the residual flexural tensile strengths obtained according to EN 14651 did not correspond clearly with equivalent flexural tensile strengths calculated in compliance with RILEM TC 162-TDF. It is noteworthy that the effectiveness and correctness of equations presented in other work of the authors referring to dependencies between deflection, crack and tip mouth opening displacements for the 3PBT were confirmed on samples with different composition and fibers. Based on the 4PBT, the equivalent flexural tensile strengths according to JCI-SF4 standard were calculated and the correlations with the results from 3PBT were defined.
Modelling of foundation stiffness beneath intermediate support of 178 m long integral viaduct
Authors: Helowicz Andrzej
Published: June 2024

The paper presents three methods of modelling of foundation stiffness beneath intermediate support of a 178 m long integral box girder viaduct and its impact on the values and distribution of displacements and internal forces in the pier of this support. The pier support is made of cast in situ reinforced concrete of strength class C50/60. For the analysis, three models were built in Abaqus FEA software. The first model A3D in Fig. 1 represents a complex three-dimensional model. The second L2D and the third H2D model shown in Fig. 2 represent simple two-dimensional models. The stiffness of the subgrade beneath the structure in the second and third model was modelled as spring constants calculated based on the equations given in the reference [8] model L2D and [10] model H2D. The middle range value of Young’s modulus for sand and gravel was used to calculate the subgrade stiffness parameters. In all models, a horizontal displacement in the Y direction of value 20 mm and a vertical force of value 18200 kN were applied to the top of the pier support. The horizontal displacement was caused by the thermal longitudinal expansion of the six-span viaduct deck and the braking force. The vertical force was caused by the dead, superimposed, and live loads acting on the viaduct deck. Finally, the values and distributions of displacements and internal forces in the pier support from the complex model were compared with the values in two simple models. The author focuses on the method of modelling of foundation stiffness of the pier support and its impact on the values of displacements and internal forces in the pier support. A similar structure analysed in this paper was design-checked by the author in Ireland [4].
The usefulness of mobile applications in shaping responsible consumption
Authors: Jaska Ewa , Werenowska Agnieszka , Balińska Agata
Published: June 2024

The main purpose of the article is to present a catalog of features of a useful mobile application in the context of responsible consumption. To recognize the usefulness of the application, examples of eco-applications were used, and representatives of the Z generation were asked about the features of the optimal application reasons for using them, and for whether they are worth recommending. The article uses the analysis of domestic and foreign literature, as well as the results of own research carried out in the first quarter of 2023, in which 747 respondents participated. The hypotheses confirmed that the most important feature of a useful application from a functionality perspective is the lack of fees for its use; from a technical solutions perspective, speed of operation, and from a security perspective, payment protection. The hypothesis that more promoters of pro-environmental mobile applications are in the group of women was also positively verified.
PENGELOLAAN VEGETASI DI KAWASAN EKOWISATA MANGROVE PERANCAK, JEMBRANA
Authors: Sundra I Ketut , Mahendra Dewi Ni Luh Putu
Published: June 2024

Perancak mangrove forest is one of the important supporters for mangrove ecotourism in perancak as an ecosystem that functions ecologically, economically and socially as an effort to preserve the beach in a sustainable manner. This research aims to determine the level of diversity of mangrove vegetation types in the perancak coastal area and conduct mangrove management efforts through vegetation analysis and soil analysis. Sampling carriedout on true mangroves and associated mangroves using purposive sampling technique. The method of flora sampling was carried out by quadrant method by calculating the important value index, diversity index and type distribution pattern.  True mangroves consist of 13 species and 1367 individuals, dominated by rhyzophora stylosa, with a total importance index (indeks nilai penting)= 299.86 % (classified as sestable), diversity index 1.1192 and distribution pattern = 0.548 (vegetation is stable and uniform).  Associate mangroves  consists of 13 types and 649 individuals, dominated by the type Terminalia cattapa. Important index =297.892 %, diversity index = 0.9438 and type distribution pattern = 0.73 i.e vegetation that grows is classified as uniform. Analysis results for the 5 soil samples for total n, p and k elements available and organic c, all support mangrove growth. the development of true mangroves and associations is the main supporting factor for the development of tourism areas in the perancak jembrana ecotourism area which is now developing into a beach park developed by the people of Perancak village.
Keywords: Perancak; Mangrove Diversity; Management; Soil Analysis
KELIMPAHAN MAKRO DEBRIS DI EKOSISTEM MANGROVE MUARA TUKAD MATI, BALI
Authors: Julihartadi I Gede Dwian , Arthana I Wayan , Ernawati Ni Made
Published: June 2024

Macro debris refers to waste materials ranging in size from 2.5 cm to 1 m, commonly found both on the water's surface and on the seabed. The accumulation of such large debris in coastal and marine environments can lead to various consequences, including disturbances to ecosystem stability and threats to the survival of organisms. Additionally, it diminishes the aesthetic quality of the environment. Among the ecosystems most susceptible to becoming repositories for this waste is the mangrove ecosystem. This study aims to quantify the amount, types, and abundance of macro debris scattered in the Tukad Mati Estuary Mangrove Area, Badung Regency, Bali. The research methodology involved several steps, starting with the selection of research stations. Transects measuring 5 x 5 meters were established. Within these designated areas, samples of macro debris were collected and categorized according to their composition, including materials such as plastic, fabric, glass, metal, and rubber. The results revealed that the total mass of macro debris collected in the Tukad Mati Estuary area amounted to 42,630 grams. The types of macro debris found in the Tukad Mati Estuary mangrove ecosystem consist of plastic, fabric, glass, metal, and rubber. Based on their quantity, the composition of macro debris is dominated by plastic at 87.02%, followed by fabric at 4.24%, rubber at 4.17%, glass at 2.67%, and metal being the least at 1.89%. Based on their weight, the composition of macro debris is highest for plastic at 32.33%, followed by rubber at 27.29%, fabric at 20.23%, glass at 14.36%, and metal being the lowest at 5.78%. The abundance of macro debris in the Tukad Mati Estuary  mangrove ecosystem ranges from 0.85 items/m² to 10.68 items/m².
Keywords: Marine Debris; Pollution; Tukad Mati Estuary; Mangrove
Pengaruh Konsentrasi Natrium Hidroksida terhadap Karakteristik Selulosa Mikrobia dari SCOBY
Authors: Fachri Balia Dwiki Yusuf , Arnata I Wayan , Wrasiati Luh Putu
Published: June 2024

Microbial cellulose is cellulose produced from a fermentation process involving bacteria and yeast, which has excellent potential as an alternative raw material to replace synthetic fibers. This research aims to determine the effect of NaOH on the characteristics of microbial cellulose and determine the concentration of NaOH that produces the best characteristics of microbial cellulose. This research used a randomized block design with varying treatment concentrations of NaOH consisting of 6 levels, namely (0%, 5%, 10%, 15%, 20%, and 25% w/v). Each treatment was grouped into three based on the microbial cellulose production time, so 18 experimental units were obtained. The variables observed were thickness, tensile strength, elongation at break, elasticity, and thickness expansion. The data obtained was analyzed for diversity and continued with the Least Significant Difference Test. The research results showed that the concentration of NaOH significantly affected the tensile strength, elongation at break, elasticity and swelling but had no significant effect on the thickness of microbial cellulose. NaOH concentration of 15% (w/v) produces the best characteristics of microbial cellulose with a tensile strength value of 39.63 ± 1.33 MPa; elongation at break is 6.43 ± 0.35%; elasticity is 607.98 ± 26.26 Mpa and thickness expansion is 126.19 ± 2.06%.
FORMULATION AND CHARACTERIZATION EFFERVESCENT TABLETS OF GAMBIER LEAF EXTRACT (Uncaria gambier Roxb)
Authors: Putra I Gusti Ngurah Agung Windra Wartana , Rismayanti Putri Putu , Wintariani Ni Putu , Suryaningsih Ni Putu Aryati
Published: June 2024

Background: Gambier, also known as the term (Uncaria gambier Roxb), is a plant that has long been cultivated in Indonesia. The components of flavonoid compounds in gambier plants have been widely reported as antioxidants. Using the gambier plant will be more accessible and more practical if it is made in dosage form, one of which is in the form of effervescent tablets. Objective: To determine the physical and chemical characteristics of effervescent tablets of gambier leaf extract (Uncaria gambier Roxb). Methods: Descriptive design, which includes phytochemical screening research, extract quality test, physical and chemical characteristics test of effervescent tablets formulation. Results: Positive gambier leaf extracts contain flavonoid compounds, alkaloids, tannins, and saponins. The average weight uniformity test of the tablet is 1.57 ± 0.02 grams, the average tablet thickness test of the tablet is 0.5±0 cm while a tablet's average diameter is 1.6±0 cm, the fragility test obtained <1%, the average hardness test of the tablet is 4.34±0.02 kg, the solubility time of the tablet obtaining is 1.6 ±0.4 minutes and tablets pH is 5.5±0.2. Conclusion: It is possible to draw the conclusion that the positive gambier leaf extract includes flavonoid components, alkaloids, tannins, and saponins based on the findings of the data previously gathered. The quality test of gambier leaf extract is already qualified, and the test of the characteristics of the physical and chemical properties produced is suitable based on Pharmacopeia Indonesia Standard.
Keywords: Gambier; Extract; Tablet Effervescent
LEADS SEARCH FOR ACETYLCHOLINESTERASE INHIBITORS DERIVED FROM SECONDARY METABOLITES OF ENDOPHYTIC FUNGI: A REVIEW
Authors: Putra Pramana Kumala , Dewi I Gusti Ayu Agung Gangga Samala , Putri Ni Wayan Prasanthi Swarna , Wirajana I Nengah , Ariantari Ni Putu
Published: June 2024

Background: Acetylcholinesterase inhibitors (AChEIs) are substances that act by increasing acetylcholine levels in the brain to prevent neurotransmitter degradation. AChEIs are the most widely used agents for Alzheimer's disease (AD) therapy so far. Objective: This study aims to give insight into AChEIs produced by endophytic fungi through literature reviews, which are promising for further studies on their mode of action. Methods: Data search was conducted through scientific-based websites such as Google Scholar, Science Direct, and PubMed, which involved scientific publications from January 2000 to December 2022. Results: Fifteen genera, including Aspergillus, Cladosporium, Colletotrichum, and Penicillium, were reported to produce twenty-four secondary metabolites with AChEI activity. These compounds were classified based on their chemical skeleton into alkaloids, steroids, terpenoids, polyketides, and peptides. Conclusion: Endophytic fungi are promising sources of lead compounds possessing AChE inhibitory activity. Further research on molecular mechanisms of secondary metabolites from endophytic fungi with AChEI activity can provide new insight into the development of more potent AChEIs for AD treatment.
Keywords: Acetylcholinesterase inhibitors (AChEIs); Alzheimer’s disease; endophytic fungi; secondary metabolites.
Factors that Influence Shared E-Scooter Usage Intentions on University Campus
Authors: Boonsiritomachai Waranpong , Sud-On Ploy
Published: June 2024

In response to increasing environmental awareness, universities have introduced shared e-scooters on campuses for staff and students. Despite these efforts, usage remains low, indicating a disparity. This study investigates factors influencing Kasetsart University (Bangkok, Thailand) students' intentions to use shared e-scooters. Using a self-administered Likert-scale survey, data was gathered from 424 qualified respondents. Multiple regression analysis was performed on 424 respondents’ representative of the population. Six factors were identified: social norms, environmental concerns, infrastructure quality, perceived convenience, safety concerns, and cost. Of these, environmental concerns and cost had no significant impact on students' intentions to use shared e-scooters at universities. This study allows stakeholders, including the student council board, e-scooter supplier firms, and university administration, to comprehend the demands of students using the e-scooters and can formulate suitable policies for environmentally friendly on-campus student mobility. Furthermore, those involved can boost e-scooter adoption to financially justify the continued investment by the university. However, it is important to note that this study is constrained by its exclusive focus on student perspectives. To address this limitation and achieve a more comprehensive understanding, future research should consider integrating qualitative methods alongside quantitative approaches, thereby enriching policy and service development for e-scooter adoption.
Keyword: intention to use; shared e-scooter; theory of planned behavior
Factors Affecting Brand Loyalty At Hotpot Restaurant In Jakarta
Authors: Keni Keni , Clarissa Stephanie
Published: June 2024

This research aims to indicate whether social media marketing, brand experience and brand image predict brand loyalty for hotpot restaurants in Jakarta, directly or indirectly, from a customer engagement perspective. One hundred forty-five respondents were consumers of hotpot restaurants in Jakarta, who distributed questionnaires online, collected data using a Likert scale, and processed it with Smart-PLS. The results show that social media marketing, brand image and customer engagement can positively and significantly indicate brand loyalty. Meanwhile, brand experience cannot positively predict brand loyalty. Finally, social media marketing and brand experience can indicate customer engagement positively and significantly. Social media marketing and brand experience can positively and significantly mediate brand loyalty. From these results, researchers hope that hotpot restaurant management can increase business competitiveness and create accurate marketing strategies to create satisfaction and the desire to enjoy the restaurant.
Beyond Convenience: Understanding E-Service Quality Role In Fostering E-Customer Satisfaction And Loyalty
Authors: Siti Yolanda Rahman Utami  , Edy Yulianto  , Agung Nugroho L.I.F
Published: June 2024

This research investigates the relationships between e-service quality, customer satisfaction, and loyalty within Indonesian e-commerce, explicitly focusing on the Shopee platform. Analyse 279 Shopee customers; the study examines the impact of website design, customer service, security, and fulfilment on e-service quality, customer satisfaction and loyalty. Using the purposive sampling method and SEM-PLS inferential analysis, the findings highlight the significant influence of website design on e-service quality. In contrast, customer service and security exhibit no statistically significant impact. Interestingly, efficient fulfilment emerges as a pivotal factor in enhancing e-service quality. This study underscores the significant influence of e-service quality in paving e-customer loyalty, directly or indirectly, via the mediating role of customer satisfaction. The implications of the research extend to actionable insights for e-commerce enterprises, offering strategic guidance to navigate and succeed in the competitive digital landscape of Indonesia.
MEKANISME SISTEM PROPORSIONAL TERBUKA PADA PEMILIHAN DEWAN PERWAKILAN RAKYAT DI INDONESIA
Authors: Hukum Jendela
Published: June 2024

The aim of this research is to analyze the mechanism of the open proportional system in the General Election of the People's Representative Council in Indonesia by referring to Law Number 7 of 2017 concerning General Elections which regulates the open list Proportional Election System, where this system can give rise to a polemic in the struggle for seats. in a very competitive parliament that has the effect of giving birth to an unhealthy model of competition between candidates that only aims to gain as many votes as possible from voters by relying solely on money and popularity. This research method uses normative juridical in answering the problems in this paper. Meanwhile, the results of the research obtained are that an open Proportional System makes it possible for anyone to nominate themselves as members of the legislature. In this system, a person who gets the most votes can take a seat as a member of the People's Representative Council even though the person concerned is at the bottom of the ballot paper.
Análisis de la participación y representación de las mujeres en la Gobernación y Asamblea de Boyacá (elecciones 2011, 2015 y 2019)
Authors: Páez Pinilla Nidia Esperanza
Published: June 2024

El presente artículo es el resultado del análisis de la participación política de la mujer en el departamento de Boyacá en los periodos 2011, 2015 y 2019, tanto en la Asamblea departamental, como en la Gobernación, no sin antes hacer un recorrido histórico de la participación democrática femenil, en Colombia y en el caso concreto en Boyacá. Dentro de esta línea se tienen en cuenta las normas y disposiciones que se han creado para la garantía de los derechos políticos de la mujer. Se evidencian qué variables afectan la participación y representación de las mujeres en la Gobernación y Asamblea de Boyacá para derivar en conclusiones y recomendaciones.
La protección a la familia en Colombia: ¿costumbrismo o modernidad?
Authors: Gómez Jiménez Julio César
Published: June 2024

El presente artículo busca revisar la transformación del concepto de familia desde la Constitución Política de 1991, teniendo como objeto determinar si la protección a esta figura se encuentra acorde a los fenómenos contemporáneos presentes en la sociedad, desde la legislación vigente, así como al derecho internacional de los derechos humanos. A través de la consulta de literatura académica, como de sentencias emitidas por las altas cortes colombianas, se busca consolidar la denominación vigente a la familia en el marco de su salvaguarda. Como resultado se evidencia que el concepto sociológico de la familia es dinámico pero que su garantía se encuentra rezagada, siendo la jurisprudencia el medio de reconocimiento de situaciones jurídicas presentes en la cotidianidad de la convivencia de las estructuras familiares.
OPTIMASI DESAIN ESP BERDASARKAN ANALISIS DATA PERFORMA PRODUKSI PADA SUMUR "ARV-13" LAPANGAN Z
Authors: Hutama Arvandhi , Setiyaningrum Priskila Rully , Nurpiansyah Edwin
Published: June 2024

Sumur ARV-13 merupakan salah satu sumur dengan metode pengangkatan buatan berupa electric submersible pump yang berada pada Lapangan lepas pantai di Sumatera Selatan. Berdasarkan data reservoir, data sumur, dan data produksi, dan performa produksi sumur ARV-13, sumur tersebut telah mengalami penurunan produksi. Penurunan kemampuan produksi tersebut menjadi salah satu faktor yang dipengaruhi oleh nilai efisiensi suatu pompa, dimana salah satu upaya untuk mengoptimasi pompa dilakukan dengan cara mendesain ulang pompa esp. Tujuan dari penelitian ini adalah untuk mengetahui performa serta nilai efisiensi pompa yang digunakan pada sumur ARV-13 pada laju alir optimum sebelum dan sesudah dilakukan desain ulang electric submersible pump. Hasil dari analisis yang dilakukan terhadap sumur ARV-13 dengan menggunakan inflow performance relationship di dapatkan hnilai laju produksi maksimum sebesar 314,8 BPD dengan laju produksi optimum sebesar 292,2 BPD. Bila digunakan tipe pompa terpasang yaitu RC1000 60Hz  efisiensi yang di dapatkan hanya sebesar 38% dari 60% serta titik kurva kemampuan produksi pompa yang jauh dari peak point. Disarankan penggantian pompa dengan tipe D475N dimana menghasilkan efisiensi lebih tinggi yaitu sebesar 44% dari 50%, serta nilai laju produksi optimum yang bertitik lebih dekat terhadap peak point pompa, yakni antara 200-625 BPD. Walaupun nilai produksi optimum sumur masih berada dalam rentang pompa terpasang, namun pompa sudah tidak efisien, maka dari itu kondisi pompa dapat di identifikasi tidak efisien sehingga memerlukan penggantian pompa
A EDUCAÇÃO DO SURDO EM MINAS GERAIS: ASPECTOS LEGAIS
Authors: Nogueira Tales Douglas Moreira
Published: June 2024

A história da educação dos surdos em Minas Gerais ainda necessita ser pesquisada e escrita. Embora venha de longa data, a escolarização destes sujeitos no contexto local ainda é pouco conhecida. A partir de Ponce de Leon (1520-1584) que ficou conhecido pelo seu método de ensino a partir do reconhecimento da língua de sinais, passando pelo Abade L’Epée (1712-1789), que também se destacou na história da educação dos surdos, muitos outros personagens se destacaram nessa história. No Brasil, o marco mais importante do início da escolarização dos surdos foi a criação do Instituto dos Surdos-Mudos do Rio de Janeiro, hoje conhecido como Instituto Nacional de Educação dos Surdos (INES). Isso foi possível graças à influência de Eduard Huet junto ao imperador D. Pedro II. O objetivo desta pesquisa é fazer um levantamento dos aspectos legais que tratam da escolarização dos sujeitos surdos, tanto na legislação nacional, quanto na legislação mineira. Este estudo é o recorte de uma pesquisa que pretende recuperar, a partir de fontes primárias localizadas no Memorial Helena Antipoff, em Ibirité, e na Sala Helena Antipoff, localizada na Biblioteca Central da Universidade Federal de Minas Gerais (UFMG), além de outras escolas especiais de Belo Horizonte, documentos e registros que discutam a educação dos surdos em Minas Gerais. Essa pesquisa está inserida dentro de uma pesquisa nacional intitulada Portal Pioneiros da Educação Especial no Brasil: personagens, instituições e práticas, que visa resgatar a memória da educação especial em cada estado da federação. Na presente fase da pesquisa, foram analisadas as leis que tratam da escolarização dos surdos, a partir da Linha do Tempo da legislação federal e mineira sobre educação especial.
СHERNOZEM SCIENCE - THE SCIENCE ABOIT CHERNOZEM
Authors: POZNIAK Stepan
Published: June 2024

The article outlines views on the modern scientific and practical significance of chernozem, emphasizing its special role in the history of science and humanity. The main attention is paid to the issues of geographical distribution, genesis, composition, structure, properties, rational use, restoration, preservation and protection. Problems related to the manifestation of degradation processes are considered: erosion, deflation, compaction, dehumification, destructuring, etc. Emphasis is placed on the role and importance of chernozems in the world of soils as a phenomenon of nature, ideal soil, feeder and means of work.
In the Cenozoic period, three events stand out - not destructive, but creating, large in their progressive consequence. In the world of plants, this is the development of angiosperm families and genera, and among them cereals, which played a prominent role in the composition of specific herbaceous and cereal phytocenoses, and later in the food base of humans and domestic animals. Mammals began to predominate in the animal world, primates appeared, as a result of their long evolution, the first humanoids appeared already in the anthropogenic period. In the world of soils, the formation of chernozems began. The initial stage is the expansion of cereals and the formation on extensive, but mainly loess plains of meadow and grass-cereal steppes, under which chernozems began to form - soils of the "gathering" type, in contrast to the already existing podzolic and feralitic soils of the "dispersive" type, which are characterized by weak accumulation humus and dispersion - removal of chemical elements - biogens and many trace elements.
Based on the analysis of extensive scientific research and publications about chernozem and its importance in society, it is expedient to develop a doctrine about chernozem and to single out a separate direction in the development of the science of soil science - chernozemology.
Black geology is a field of soil science that studies the formation (genesis), structure, composition and properties, patterns of geographical distribution, processes of interaction with the external environment, which determine the formation and development of the main property - fertility, ecological and social functions, aesthetic value, ways of rational use, reproduction, preservation and protection.
The question of chernozem and its degradation in the modern world is not only agronomic, ecological, economic, legal, aesthetic, but also political. Radical and tough decisions are needed so that the quiet crisis of the planet does not turn into a loud one in the foreseeable future.
Evaluating the global importance of chernozem in the world of soils, it is advisable to develop a special course "Chernozem Science" for students of natural and agricultural specialties of higher educational institutions of Ukraine.
Key words: chernozem, natural phenomenon, degradation, erosion, morphology, properties, ideal of perfection, aesthetic value.
Clinical characteristics and pathological features of undetectable clinically significant prostate cancer on multiparametric magnetic resonance imaging: A single-center and retrospective study
Authors: Yamamoto Takahiro , Okada Hiroaki , Matsunaga Nozomu , Endo Makoto , Tsuzuki Toyonori , Kajikawa Keishi , Suzuki Kojiro
Published: June 2024

Objectives:

The objectives of this study were to clarify the pathological features of clinically significant prostate cancer (csPC) that is undetectable on multiparametric magnetic resonance imaging (mpMRI).

Material and Methods:

This single-center and retrospective study enrolled 33 men with prostate cancer (PC), encompassing 109 PC lesions, who underwent mpMRI before radical prostatectomy. Two radiologists independently assessed the mpMR images of all lesions and compared them with the pathological findings of PC. All PC lesions were marked on resected specimens using prostate imaging reporting and data system version 2.1 and classified into magnetic resonance imaging (MRI)-detectable and MRI-undetectable PC lesions. Each lesion was classified into csPC and clinically insignificant PC. Pathological characteristics were compared between MRI-detectable and MRI-undetectable csPC. Statistical analysis was performed to identify factors associated with MRI detectability. A logistic regression model was used to determine the factors associated with MRI-detectable and MRI-undetectable csPC.

Results:

Among 109 PC lesions, MRI-detectable and MRI-undetectable PCs accounted for 31% (34/109) and 69% (75/109) of lesions, respectively. All MRI-detectable PCs were csPC. MRI-undetectable PCs included 30 cases of csPC (40%). The detectability of csPC on mpMRI was 53% (34/64). The MRI-undetectable csPC group had a shorter major diameter (10.6 ± 6.6 mm vs. 19.0 ± 6.9 mm, P < 0.001), shorter minor diameter (5.7 ± 2.9 mm vs. 10.7 ± 3.4 mm, P < 0.001), and lower percentage of lesions with Gleason pattern 5 (17% vs. 71%, P < 0.001). Shorter minor diameter (odds ratio [OR], 2.62; P = 0.04) and lower percentage of Gleason pattern 5 (OR, 24; P = 0.01) were independent predictors of MRI-undetectable csPC.

Conclusion:

The pathological features of MRI-undetectable csPC included shorter minor diameter and lower percentage of Gleason pattern 5. csPC with shorter minor diameter may not be detected on mpMRI. Some MRI-undetectable csPC lesions exhibited sufficient size and Gleason pattern 5, emphasizing the need for further understanding of pathological factors contributing to MRI detectability.
Implementation of Complete Systemic Land Registration Program's Policy (PTSL) in Mojomanis Village, Kwadungan District, Ngawi Regency
Authors: Pramodya Pradhana Angga , Rahardjo Mudji , Pramodya Dwipayana Dimas , Misbahuddin Yusui Naufal
Published: June 2024

This study aims to determine the implementation of the Complete Systematic Land Registration (PTSL) program policy in Mojomanis Village, Kwadungan District, Ngawi Regency. 24 of 1997 which was later replaced by Regulation of the Minister of Agrarian Affairs and Spatial Planning / Head of the National Land Agency of the Republic of Indonesia No. 12 of 2017 concerning Land Registration. The type of research carried out is empirical or sociological, namely research that examines the law in reality or reality in the community/regarding its behavior to find out the implementation and implementation constraints of the Complete Systematic Land Registration (PTSL) program in Mojomanis Village, Kwadungan District, Ngawi Regency according to the Regulation of the Minister of Agrarian Affairs and Spatial Planning/Head of the National Land Agency No. 6 of 2018 concerning Complete Land Registration in accordance with Village Minister Regulation Number 14 of 2020. The results of this study explain that the implementation of Complete Systematic Land Registration in Mojomanis Village, Kwadungan District, Ngawi Regency has been running well and in accordance with established regulations. The inhibiting factors in the implementation of Complete Systematic Land Registration in Mojomanis Village, Kwadungan District, Ngawi Regency are divided into two, namely technical and legal obstacles. One of the efforts to overcome these obstacles is by using the method of deliberation and sitting together
Law Enforcement in Suppressing the Spread of the Covid-19 Virus through the Implementation of Restrictions on Community Activities's Policy (PPKM)
Authors: Gunawan Akhmad Wahyu
Published: June 2024

The world is facing a disaster caused by the coronavirus disease 019 (COVID-19) pandemic where this virus has more or less infected more than six million people and claimed more than 370 thousand lives worldwide. The exposure to the spread is quite fast, one of which is Indonesia enacting the Policy for Enforcement of Community Activity Restrictions (PPKM) to suppress the spread of the corona virus. The problems that the author will describe are related to law enforcement efforts through PPKM policies and the legal basis related to sanctions given to the community who subscribe to health protocols. The research uses a normative method by using a statutory approach, books, journals, articles. The results of the study conclude that PPKM law enforcement can be concluded that it is still not effective, because looking at the reality there are still many non-essential and non-critical sectors that are still operating as usual, this can be seen from several factors, namely, legal factors, cultural factors, community factors, special factors imposing sanctions and the legal basis for the application of sanctions against people who do not comply with health protocols are clear in Article 93 of Law Number 6 of 2018 concerning Health Quarantine
Pengaruh Penerapan Media Pembelajaran Mind Mapping Berbasis Problem Solving untuk Meningkatkan Hasil Belajar Mahasiswa pada Mata Kuliah Bengkel Listrik
Authors: S Anton
Published: June 2024

Penelitian  ini  bertujuan  untuk  mengetahui  pengaruh  penggunaan  media
pembelajaran  Mind  Mapping  terhadap  hasil  belajar  mahasiswa  pada  mata  kuliah  Bengkel
Listrik.  Dalam  pembelajaran  mata  kuliah  Bengkel  Listrik  kurang  adanya  kolaborasi
penggunaan  media  pembelajaran  yang  efisien,  membuat  mahasiswa  kurang  aktif  dalam
pembelajaran  serta  minat  belajar  mahasiswa  menjadi  kurang  sehingga  hasil  belajar
mahasiswa  menjadi  rendah.  Penelitian  ini  berbentuk  penelitian  kuantitatif.  Sampel  yang
digunakan  satu  kelas,  diambil  menggunakan  teknik  sampling  jenuh  dengan  kelas  sebelum
perlakuan  (pretest)  diajar  dengan  mentode  konvensional/ceramah  dan  kelas  sesudah
perlakuan  (posttest)  diajar  dengan  media  pembelajaran  trainer  elektronika.  Teknik
pengumpulan  data  menggunakan  metode  tes  untuk  data  hasil  belajar  mahasiswa.  Teknik
analisis data menggunakan  uji t.  Berdasarkan hasil  uji  t  yang menunjukkan  bahwa  t
hitung
=
24,74 dan t
tabel
= 1,78 untuk db = 12 dan taraf signifikansi 5%, thitung > ttabel, sehingga hipotesis
penelitian  terbukti  atau  diterima.  Simpulan  pada  penelitian  ini  adalah  ada  pengaruh  dari
penggunaan media pembelajaran Mind Mapping terhadap hasil belajar mahasiswa pada mata
kuliah Bengkel Listrik.
A molecular modeling study to identify novel anticancer phytocompounds against the Tankyrase 1 protein
Authors: Subburaj Saranyadevi , Veerappapillai Shanthi
Published: June 2024

Tankyrase 1 is considered a promising target for various cancer treatments. The inhibition of Tankyrase 1 has long been considered as a substantial challenge for cancer therapy due to its on-target intestinal toxicity. Therefore, an effort was taken to identify novel and potent inhibitors of Tankyrase 1 target by employing various computational approaches from the natural products library. Hence, in our study, we employed integrated pharmacophore strategies, docking and binding energy of the 1574 compounds from the NPACT database against the Tankyrase 1 target. Two anti-cancerous moieties from this database have yielded better docking scores alongside their superior binding free energies than the XAV939 (reference). The root mean square deviation (RMSD) and H-bond etc. were also evaluated for both the hit molecules (Taxiresinol and 5-O-caffeoylshikimic acid) through dynamics simulation studies for 50 ns. Both the compounds depict a constant deviation in comparison with the reference compound. Altogether, our study uncovers two best hits that could be promising drug candidates against cancer.
Morphological traits according to BMI of LRP5 rs121908669 genotype carriers
Authors: Shahrour Eiman , AL-Halabi Bassel , Al-Achkar Walid , Hassan Abd Alrazak , Yazigi Haissam
Published: June 2024

Descriptive diagnostic is a part of clinical diagnosis. It is not reliable, but it is prompt. Therefore, it is necessary to determine the phenotypes of the genotypes of carriers of LRP5G171R. This cross-sectional study was performed on 150 premenopausal and postmenopausal women with a mean age of 40 years. Body mass index (BMI) was calculated. To determine the genotypes of LRP5 rs121908669, a PCR-RFLP assay was performed and the results were confirmed by DNA sequencing. The likelihood test, chi-square test, binary logistic regression test and odds ratio test were used to determine the associations between BMI and the genotype of LRP5G171R. The likelihood test confirmed the relationship between BMI and LRP5G171R (ϰ2 =15.658, p=0.048). The results indicate that there are positive correlations between obese BMI and extremely obese BMI and between obese BMI and GG (ϰ2 =23.707, 14.013 p=0.000, 0.00). There was a negative correlation between normal BMI and GG (ϰ2 =19.675, p=0.000). There was a negative correlation between extremely obese BMI and CC (ϰ2 =12.466, p=0.000). There was a negative correlation between BMI and GC in obese individuals (ϰ2 =19.997, p=0.000). Finally, obesity and extreme obesity are positive factors. The carriers of the mutant LRP5G171R (GC, CC) will be protected from obesity, unlike carriers of the normal genotype (GG) which will suffer from obesity. This SNP can be added to NCBI as an SNP associated with obesity.
Antagonistic potential of Trichoderma strains isolated from Musa paradisiaca cv. Malnad Rasbale grown farmyards against Foc race 4 pathogen
Authors: Prasanna Sadarahalli Ullas , Krishna Venkatarangaiah , Kumar Shivakumar Ravi , Ajith Sheshagiri , Nayaka Sachin Somashekar
Published: June 2024

Foc race 4 is a causative pathogen for Panama wilt disease of Musa Paradisiaca cv. Malnad Rasbale. The cost-effective measure to control rather than the usage of agrochemicals is still not available for this cultivar. Trichoderma strains act as an antagonistic agent against different phytopathogenic fungi including many pathogenic races of Panama wilt-causing pathogens. An attempt has been made to recognize the mode of action of this antagonistic agent in in vitro conditions and interaction between six Trichoderma strains. Foc race 4 was first investigated by dual plate culture method on PDA medium. This study revealed the potential of native strain KUVKU-TH02 for the biological control of Foc race 4 pathogen affecting Malnad Rasbale cultivar in in vivo conditions rather than native isolates KUVKU-TH01, KUVKU-TV01 and KUVKU-TV02. Observations revealed the lysis of hyphal ending in inhibited colonies of the fungal pathogen. Pure culture of isolated fungal strains incubated on potato dextrose broth made a path to isolate DNA for identification and molecular characterization studies. Upon DNA sequencing, native isolates sequences were deposited to NCBI genebank to gain accession IDs. The phylogenetic tree built showed the evolutionary relationship between the isolates and also the potency of native biocontrol isolates against procured isolates.
LCMS Analysis, Antioxidant, Anti-Proliferative and Antimicrobial Activities of Combined Papaya, Honeydew and Mango Fruit Peel Extract
Authors: Salfarina Ramli , Malik M.N.S.A. , Richard Johari James , Hasseri Halim
Published: June 2024

Fruit peels have traditionally been viewed as waste by restaurants, markets and the food and beverage industry, leading to their routine disposal. However, there has been a recent recognition of the valuable phytochemicals present in fruit peels which has increased interest in exploring their biological activity. In this study, a fruit peel extract was produced by macerating a combination of dried mango, papaya and honeydew peels with 95% ethanol at 50°C. The study aimed to identify the flavonoids in the fruit peel extract and to evaluate its pharmacological activities. The flavonoids were identified using the LC/MS-QTOF system and its antioxidant activity was measured using the DPPH and nitric oxide (NO) scavenging assays. The anti-proliferative and antibacterial activity of the extract were investigated using the MTT assay and disc diffusion method. The phytochemical analysis tentatively identified six flavonoid compounds in the ethanolic crude extract based on the database screening. The results showed that the peel extract was more effective at scavenging DPPH than NO. Additionally, the extract was found to be rich in phenolic compounds, containing 416 mg of gallic acid equivalents per gram of dry weight. Although the hexane fraction showed the lowest activity, the ethyl acetate fraction showed better antimicrobial activity towards all tested bacteria compared to the crude extract. Despite the high concentration of phenolic compounds, no significant anti-proliferative activity was observed in the extract. The study recommends exploring the possibility of using selected fruit peel extracts as natural resources of preservative and antioxidant agents in the future.
Potentiometric Application of CeFeMoP and CeAlMoP in Zr(IV) Ions Analysis: A Comparative Study
Authors: Yadav S. , Sharma N. , Sharma H.K.
Published: June 2024

Two cerium-based ionophores Cerium(III) ironmolybdophosphate (CeFeMoP) and Cerium(III) aluminomolybdophosphate (CeAlMoP), were synthesised, having ion exchange capacities of 5.76±0.1 and 5.6±0.2 meq/gm respectively. Electroanalytical studies of synthesised heteropolyacid salts have been done using epoxy resin as binder material to form membranes of variable compositions. The potentiometric observation supports the behaviour of 40% membrane in both cases. CeFeMoP-based electrode showed a linear range from concentration 1x10-6 to 1x10-1 M and a limit of detection 6.31×10-7 M. In contrast, these parameters in the case of CeAlMoP are of linear range from 1x10-7 M to 1x10-1 M, response time 22 seconds and a limit of detection 5.01 × 10-7 M. Membranes yielded a rapid response time of 15 seconds in the case of CeFeMoP. The membranes performed very well in the case of internal concentration variations of the same solution and several other types of non-aqueous media. The FIM method proves the selectivity of the electrode even in the presence of interfering ions. CeFeMoP based sensor performed over a constant potential behaviour in pH values ranging between 3.32-8.26 while CeAlMoP based electrode worked in the pH range of 3.25-10.54 for a constant internal concentration of Zr(IV) ions. The two sensors also performed well as indicator electrodes as well as in real-time sample analysis. Hence, it is concluded that these sensors derived from CeFeMoP and CeAlMoP are quite effective in analyzing the Zr(IV) ions in various samples with quick response time and a lifetime of around 8 and 7 months respectively. A real field study was also performed by using an ICP-MS analyzer.
Isolation, Characterization and Identification of Halophilic bacteria from Solar saltern of Khambhat, Gujarat, India
Authors: Chaudhari Hiral G. , Wardah Zuhour H. , Raol Gopalkumar G.
Published: June 2024

The solar salterns of Khambhat, Gujarat are distinct biological niches distinguished by high salinity levels and harsh environmental circumstances. Our goal in this work was to isolate and characterise bacteria in order to investigate the diversity of microbes found in these saline soils. Standard microbiological procedures were used to isolate the bacteria from samples taken from various depths of the solar saltern ponds. To clarify their taxonomic identity and physiological characteristics, the isolated bacterial strains underwent morphological, biochemical and molecular characterization. Catalase, oxidase and fermentation assays are examples of biochemical studies that shed light on the isolated strains' metabolic capacities. Moreover, the phylogenetic relationships of the isolated bacteria were ascertained through molecular characterization using 16S rRNA gene sequencing. This work advances our knowledge of the microbial ecology of hypersaline environments and highlights the potential uses of bacteria isolated from these settings in biotechnology such as bioremediation, the synthesis of enzymes and the identification of new bioactive substances. To fully utilize these bacteria's biotechnological potential, more research into their functional properties is necessary.
Nouvelles données d’hyménoptères parasites (Chalcidoidea ; Cynipoidea ; Ichneumonoidea) capturés dans le domaine du Rond-Chêne (Esneux, Province de Liège) et focus sur les espèces de Zatypota Förster (Ichneumonidae : Pimplinae : Polysphinctini) présentes en BelgiqueHyménoptères parasites nouveaux pour la Belgique
Authors: LIBERT Pierre-Nicolas
Published: June 2024

Dix-sept espèces d’Hyménoptères parasites (Chalcidoidea: Eulophidae, Pteromalidae; Ichneumonoidea: Braconidae, Ichneumonidae) sont signalées pour la première fois en Belgique: Aprostocetus elongatus (Förster, 1841), Psilocera confusa Graham, 1992, Eubazus nigroventralis van Achterberg, 2003, Dendrosoter hartigii (Ratzeburg, 1848), Doryctes undulatus (Ratzeburg, 1852), Ecphylus hylesini (Ratzeburg, 1852), Ecphylus eccoptogastri (Ratzeburg, 1848), Leluthia transcaucasica (Tobias, 1976), Spathius brevicaudis Ratzeburg, 1844, Meteorus hirsutipes Huddleston, 1980, Syntretus ocularis van Achterberg & Haeselbarth, 2003, Stauropoctonus bombycivorus (Gravenhorst, 1829), Stilbops limneriaeformis Schmiedeknecht, 1888, Zatypota albicoxa (Walker, 1874), Zatypota anomala (Holmgren, 1860), Zatypota bohemani (Holmgren, 1860) et Zatypota picticollis (Thomson, 1888). Zatypota discolor (Holmgren, 1860) est exclue de la liste des espèces belges. Une note détaillée est fournie pour chaque espèce nouvelle. Une carte de répartition est présentée pour les espèces du genre Zatypota Förster.
Inventaire préliminaire des relations entre pucerons myrmécophiles et fourmis des parcelles agricoles en périphérie de la ville d’Antananarivo (Madagascar)
Authors: Luttenschlager Hugo , Noël Grégoire , Carpentier Joachim , Glacet Lallie , Ravelomanana Andrianjaka , Rakotonirina Jean Claude , Rajaonera  Tahina , Francis Frédéric
Published: June 2024

Cette étude avait pour objectif de fournir un inventaire préliminaire des interactions entre différentes espèces de fourmis et de pucerons myrmécophiles en périphérie d’Antananarivo. Nous avons identifié cinq espèces de pucerons exotiques, tels que Aphis fabae Scopoli 1763, Aphis citricidus (Kirkaldy 1907), Rhopalosiphum maidis (Fitch 1856), Aphis spiraecola Patch 1914 et Macrosiphum euphorbiae (Thomas 1878), sur un total de quatre espèces de plantes hôtes en interaction avec quatre espèces de fourmis mutualistes : Monomorium madecassum Forel 1892, Nylanderia gracilis (Forel 1892), Camponotus liandia Rakotonirina & Fisher 2018, Camponotus maculatus (Fabricius 1782). Dans cet article nous détaillons quelles espèces ont été en interaction. Enfin, nous discutons d’éventuelles raisons qui pourraient expliquer ces observations, comme le régime alimentaire de pucerons et nous proposons quelques pistes pour de futures recherches.