bluuebunny/crossref_metadata_2025 huggingface dataset:
Telomere and Telomerase: Brief review of a history initiated by Hermann Müller and Barbara McClintock.
Authors: Chuaire Lilian
Published: July 2024

What is the nature of the biological clock that determines the cells aging? What is the way to explain the genesis of diseases associated in aging? The above are only some of the questions whose answer could be found within the modus operandi frame of the telomere-telomerase pair, which had become in objective of study for a number of science men and women since the pioneers Hermann Müller and Barbara McClintock, until the most recent Jack Szostak, Elizabeth Blackburn and Carol Greider, among others.
Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity.
Authors: Bonilla Javier Fernando , Sánchez Magda Carolina , Chuaire Lilian
Published: July 2024

Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis. G6PDH deficiency is the most common X-chromosome-linked enzymopathy in human beings. Although it is present in any type cell, its absolute deficiency is incompatible with life. According to WHO, 400 million people are affected by G6PD deficiency in the world but in Colombia, the severe form prevalence is about 3% to 7%. There are no data related to slight and moderate alterations, that also have clinical effects. This paper reviews some G6PD biomolecular aspects, its classification according to activity and electrophoretic mobility, as well as some main clinical aspects related to its activity alteration.
Facial paralysis in the ceramic the Tumaco-Tolita pre-Columbian culture (300 BC to -600AD).
Authors: Pachajoa Harry , Rodríguez Carlos Armando , Isaza Carolina
Published: July 2024

Introduction: The Tumaco-Tolita culture occupied the geo-historic region of the Pacific Colombo-Ecuadorian coast from 300 BC to -600 AD. This culture was characterized for capturing with impressive realism the different pathologies that suffered their population, as well as evidence of genetic illnesses, congenital malformations, and processes of aging and death. Objective: To describe the evidences of neurological illnesses, and mainly the ones related to facial paralysis in the ceramic of the Tumaco-Tolita culture in the Universidad del Valle Museum «Julio César Cubillos» at Cali, Colombia. Methods: The collection pieces of the Tumaco-Tolita culture of the Universidad de Valle archaeological museum «Julio César Cubillos», were examined by a geneticist physician, a physician trained in the area of medical genetics, and an archaeologist. Cases with evidences of neurological illnesses and mainly facial paralyses were documented. Results: Out of the 500 examined pieces, 6 were found with clear evidence of facial paralysis, and out of them, the 3 that better showed this pathology were chosen. Conclusions: The Tumaco-Tolita culture represented facial paralyses in their ceramics, constituting one of the first registries of these conditions in the American pre-Columbian cultures.
Inflammatory bowel diseases: an update of current treatment alternatives.
Authors: Suárez Lucrecia , Agrimbau Jorge Diego , Fuentes Daniel
Published: July 2024

Inflammatory bowel diseases (IBD) are characterized for having an unpredictable clinical course with periods of inactivity alternating with relapses, a very variable response to treatment and the constant threat of diverse complications. Management of IBD in children may be of particular complexity, added to the fact that published clinical trials are limited, and scientific evidence seems contradictory, explain in part why to current date there is no international consensus regarding treatment in this age group. A suitable therapy should aim at inducing and maintaining remission for as long as possible, encourage adequate growth and preventing potential complications from appearing. In more recent years, development of new therapeutic agents has allowed a more integrative approach which takes in consideration other aspects of the disease such as nutritional status, psychological welfare and general quality of life. One must also keep in mind that none of these therapeutic resources is exempt of side effects on short and long term basis, consequently, it is imperative to be thoughtful of individual features in order to make accurate clinical decisions and offer a tailored management plan which should be able to modify the disease evolution.
Etiology and bacterial sensibility in children urinary infection. Hospital Infantil Club Noel and Hospital Universitario del Valle, Cali, Colombia.
Authors: De Castaño Iris , González Claudia , Buitrago Zaidy Yahaira , De Rovetto Consuelo
Published: July 2024

Introduction: Urinary tract infection (UTI) is the most common renal disease in childhood. To find the etiologic microorganism and an early adequate antibiotic therapy are essential to avoid permanent kidney injuries. Objectives: To know the etiologic bacteria and their antibiotic sensibility in urine cultures of children with UTI consulting University Hospital and Club Noel Hospital in Cali, Colombia. Methodology: A total of 123 children under 14 years of age that came into Emergency Service or outpatient clinics at University Hospital or Club Noel Hospital with clinical suspicion of UTI from August 2004 to February 2005 were included in a descriptive transversal study. Urine cultures were taken by supra-pubic aspiration, urine catheterization or mid strain urine. UTI definition was based on colony counts according to recollection method. Positive urine cultures, type of bacteria and antibiotic sensibility were considered for the analysis. Children having either urine cultures with colony counts inferior to recollection method, asymptomatic bacteriuria, occasional catheterization, immunosuppression, vesicostomy or previous admission to intensive care unit, were excluded. Results: Among 123 children entering to the study, 31 were eliminated for colony counts inferior to the recollection method. A total of 123 urine cultures were left for the analysis: 50% of urine cultures were obtained by catheterization, 33% via mid void stream and 17% by supra-pubic aspiration; 58% of patients were females. Escherichia coli was cultured in 72% of the cases, Klebsiella in 16.4%, Proteus 2.5% and other type of bacteria account for 9%. Antibiotics and antibacterials with sensibility over 80% were: cefixime, norfloxocin, cefuroxime, cefprozil, nalidixic acid, ceftriaxone, amikacin, and gentamicin. Intermediate sensibility from 61 to 70%: amoxicillin-clavulinic, cefaclor, ciprofloxacin, and nitrofurantoin. Sensibility under 60% was found for amoxicillin, ampicillin, cefadroxil, cephalexin, cephradine, trimethoprim-sulfa, ampicillin–sulbactam, cephalothin and cefazolin. Conclusions: E. coli is the main cause of UTI in the pediatric population of Cali. Usual recommended antibiotic and antibacterial for UTI empiric therapy are cephalexin, trimethoprim-sulfa, ampicillin, and amoxicillin. In accordance with the results in the present study resistance of bacteria to these medicaments was high. Antibiotics and antibacterials with better sensitivity were: cefuroxime, cefproxil, cefixime and nalidixic acid which the authors recommend for empiric oral therapy while the urine culture is in process and final results arrive. In spite of norfloxocin good sensitivity, its use should be reserved for especial cases where resistance to other antibiotics is found. If there is an indication for intravenous treatment, ceftriaxone or amikacin are recommended.
Health reform and malaria control in two endemic areas of Colombia, 1982-2004.
Authors: Jiménez Mónica Marcela , Hinestroza Yenifer , Gómez Rubén Darío
Published: July 2024

Introduction: During the last years Colombian health policy has experienced deep  changes whose effects on public health are controversial. Objectives: Case study carried out in two municipalities in order to describe the changes in malaria control program and its relationship with Colombian health reforms. Methodology: The municipalities of Zaragoza and Tarazá were selected because they present high rates of   malaria incidence in the department (state) of Antioquia, Colombia. The study combined qualitative and quantitative techniques to obtain and to process the information. The official files of the program were analyzed for the period 1982-2004. Key informants, selected by their experience with malaria and its control programs, were interviewed. Results: In connection with the policy for malaria control, three moments were identified: the vertical program  under Ministry of Health (1975-1982) responsability; the departmental program (1983­1990); and the organization of the program according to the regulated competition model (1991-2004). During the second moment improvement in the control activities accompanied by a reduction of the mortality were observed. Since 1991, a deterioration in the control of malaria, associated  to the decentralization and the subjection of the sanitary politics to the principles of the market, was noted; this deterioration is characterized by the progressive lost of force of the responsibility of the State on malaria control, the loss of the installed capacity and the Know-How, the fragmentation of control actions, the collapse of information systems and the deterioration of mortality and morbidity indicators. Conclusions:  Both observed cases suggest a detriment in the efficiency, effectiveness and quality of malaria control actions, associated with health reforms implemented in Colombia since 90s, which could also be  present in other municipalities of the country.
Surgical radical excision alone as a treatment for the giant condyloma acuminatum: a case report.
Authors: Parapar Indalecio , Taboada Noel
Published: July 2024

Condylomas or genital warts are caused by the human papilloma virus, from which exist more than 100 different genotypes. About 40 of them are sexually transmitted. We report a case of a female patient with a giant condyloma acuminatum in the vulvar perineal and perianal regions, of around five years of course, which disturbs her urination, sexual intercourse, and even walk; accompanied by pruritus, foul-smelling, and occasionally pain. The histopathological study was compatible with condyloma acuminatum. She was treated conservatively with radical local surgical excision of the tumor with excellent functional and cosmetic results. No postoperative complications were observed. A year later there were neither recurrences nor hypertrophic scars. We consider interesting to publish it due to it’s the first case published in the state of Eritrea, developing country of the horn of Africa.
Reminiscences of graduate medical training in Colombia.
Authors: Villaquirán Jaime
Published: July 2024

Historical portrayal of how the formation of higher medical education, post-graduated specialties, developed in Colombia, dating from 1940 until 1992. In 1992 the Colombian government organizes Higher Medical Education by Law N° 30 passed on the 28 of December of 1992. In the article the author expresses how more organized this education may have become it may have lost some of its mystic and ethical vitality.
The impact of the impact factor ¿myth or reality?.
Authors: Leon Sarmiento Fidias E. , Leon S. Martha E. , Contreras Víctor A.
Published: July 2024

The evaluation of scientific production in Latin America has had several eras being the numerical impact factor (FIN) the one that became the most popular one in recent years; unfortunately, the FIN measures journal popularity more than journal prestige. Thus, a lot of idiomatic, mathematical and scientific biases prevent the use of the FIN as a Latin American bibliometric measurement. New scienciometric methods such as webometrics and the like developed in more scientific way that than obtained by the Institute of Scientific Information must be considered from now on. It includes the Page Rank and the Y Factor both of which seem to give more consistent results than those obtained with the FIN. Due to this, it is mandatory to continue the analysis and, hopefully, to get a re-evaluation of the FIN as an universal scienciometric measure, mostly in Spanish-speaking countries as it has already been advanced in some academic and scientific circles of the so-called first world.
Agnathia holoprosencephaly complex: case report.
Authors: Suárez Obando Fernando , Prieto Juan Carlos
Published: July 2024

A case report of the agnathia holoprosencephaly complex and a review of the literature related to the complex genetic and embryologic aetiology of this group of major birth defects of face and central nervous system are informed. The present clinical case is the first reported in Colombia.
Carrier frequency of F508del mutation of cystic fibrosis in medical students from Universidad del Rosario, Bogotá, Colombia.
Authors: Mateus Heidi Eliana , Fonseca Dora Janeth , Sánchez Lina S. , Peñaloza Iván F. , Forero Diana V. , Perdomo Pamela A. , Quiasua Diana C. , Ramírez Alexander , Montoya Laura C. , Pérez Luis A. , Amado Hilda P. , Molano Jorge A. , Amaya Sergio A. , Durán María H. , Cárdenas Vanesa C. , Guevara Karen , Parga Diego A. , Esparrogosa Claudia L.
Published: July 2024

Introduction: Cystic fibrosis (CF) is the most frequent autosomical recessive disorder in Caucasian population with an incidence of 1 in 2000 newborns. The disease is caused by mutations in the cftr gene, but the most common mutation is F508del, which accounts for 66% of CF chromosomes worldwide and a carrier frequency for Caucasian population of 1 in 25. Objective: To determine the carrier frequency of the F508del mutation in 110 unrelated, healthy students from the Facultad de Medicina, Universidad del Rosario. Methods: The presence of F508del mutation using PCR and heteroduplex analysis was determined. Results: Only four heterozygotes for F508del mutation were discovered. This represents a carrier frequency of 1 in 27 students. Conclusions: This estimated frequency of F508del carriers is higher than expected, encouraging further screening in normal control individuals from different regions of Colombia.
Factors associated with daily cigarette smoking among 60-65 aged adults: a cross-sectional study.
Authors: Campo Adalberto , Díaz Luis Alfonso
Published: July 2024

Background: Cigarette smoking decreases gradually with aging. However, an important number of people older than 60 years continue smoking. Objective: To know the prevalence and associated factors with daily cigarette smoking among adults aged between 60- and 65-years old from the general population of Bucaramanga, Colombia. Method: A cross-sectional study was carried out among 60- and -65 years old adults. Sociodemographic characteristics, medical condition, coffee intake, abusive alcohol consumption, common mental disorders, personality features (DSM-IV), and daily cigarette smoking within the last month were evaluated. Confounding factors were controlled with non-conditional logistical regression. Results: A group of 208 people were interviewed. The mean age was 62.9 years (SD, 2.0); the mean education was 6.1 years (SD, 3.7); 67.3% of them were women; 68.3% were married; 45.2% had an employ; 77.4% lived in middle class neighborhood; 40.9% suffered from a medical condition; 40.9% drunk coffee within the last month; and 12% reported a common mental disorder. A ratio of 30.8% reported cluster A personality features; 37.5%, cluster B; and 53.8%, cluster C. The prevalence of daily cigarette smoking was 6.3% (95% CI 3.0-9.6), and it was associated with daily coffee drinking (OR 13.9); after controlling for sex and abusive alcohol consumption. Conclusions: Cigarette smoking is present in one out of sixteen people aged 60-65 years-old, and it is related to other risk-health behaviors.
Uveitis in patients with diagnosis of seronegative spondyloarthropathies. Hospital Pablo Tobón Uribe, Medellín, Colombia.
Authors: Molina Carlos Andrés , Donado Jorge Hernando , Vélez Liliana María , Martínez Natalia Andrea , Rivera Ana Isabel
Published: July 2024

Objective: To describe the inflammatory ocular manifestations in patients with diagnosis of spondyloarthropathies. Design: Descriptive study, longitudinal series of cases. Methods: In patients fulfilling inclusion criteria was carried out a complete ophthalmologic examination. The medical histories were revised. Data were registered in a previously built form. Results and conclusions: Frequency of uveitis, 37.5%; unilateral, 88.9%; and bilateral, 11.1%; not alternating, 88.9%; recurrence, 77.8%; anterior uveitis, 88.9%; cataracts were the main complication; in most of the patients the inflammation was resolved spontaneously; ocular inflammation usually was present after the beginning of the systemic symptoms. The most frequent spondyloarthropathy was ankylosing spondylitis in 58.3%. In conclusion, this study describes the connection between uveitis and spondyloarthropathies as given in the literature and it represents the first study showing this relationship behavior in Medellín, Colombia.
Process Evaluation of the Healthy Schools Strategy in the urban area in Cali, Colombia
Authors: Gutiérrez Alejandra María , Gómez Olga Lucía
Published: July 2024

Background: Health Promoting School (HPS) is the strategy to integrate health promotion initiatives in the school. In 2004, all of the primary public schools of Cali were covered by the strategy. A process evaluation of HPS is needed for its adjustment. Objectives: To carry out a process evaluation of the HPS. The study explores the conceptual coherence between the guidelines of the strategy and the rationale and practice of the personnel in charge of its implementation; the mechanism of coordination inside the Healthy Schools Network (HSN); and the achievements, constraints and facilitators perceived by people involved in the strategy. Methods: A qualitative process evaluation was carried out, based on the Potvin model. Data collection involved documentary review, interviews and focus groups. A purposing sample was made taking into account schools typology. The analysis entails on reading of the texts, codification with a priori and emergent categories, building of analytical charts and interpretation of the findings. Results: There is conceptual coherence regarding HPS from the international level to the local one, this is reflected in the rationale and the practice of personnel of Health Sector and the schools and it is less detected in the personnel of some actors of other institutions. HSN was brought to the initiative coherence in objectives and methods between actors, but it lacks a bigger articulation among the three levels of the Network  (central node, municipal administration; neighborhoods node, local level; executive group, schools). The achievements are related to the improvement of the management of the schools and the health of the children; the facilitators to the management capacity of the schools and the will of chiefs and teachers to participate in the HPS; and the constraints to intersectorial coordination. Conclusions: It is necessary to strengthen intersectorial coordination and the involvement of the strategy in community process which happens near of each school in order to consolidate HPS as a public policy. It is essential and important to reinforce this kind of research in Colombia and Latin America.
Predictive factors acting on health promotion behavior of menopausic women at Cali, Colombia.
Authors: Triviño Zaider , Stiepovich Jasna , Merino José M.
Published: July 2024

Introduction: Women have raised life hope in last decades; this coincides with their vital cycle of peri- post-menopausal apparition. This period present complex changes in it’s by a psycho, sociocultural dimension that implies a position of the women role and negative repercussions in their life quality. Aim: To determine the predictive factors influencing the health promoter behaviors (HPB) in peri- post-menopausal women of Cali, Colombia, according to Pender’s model. Material and methods: A descriptive design, non observational, transversal and correlational, of a bietapic conglomerate sample of 650 peri- post-menopausal women between 45 and 60 years old was applied. HPB and biopsychosociocultural factors were studied. The following instruments were applied: scale of health promoter life style, perception of self-efficiency scale, and health state and peri- post-menopausal knowledge scale. Results: Of the women 54% obtained a HPB higher than the average. The strongest HPB in the peri- post-menopausal women were: spiritual growth (64.3%), interpersonal relationships (60.7%), stress management (57.9%), nutrition (57.3%), health responsibility (54.9%) and a deficient physical activity (49%). According to the multiple regression model, the factors suffering more variability, 37.1%, were: health state perception (R2=21%, p< 0.0001); self-efficacy perception (R2=20.5%, p< 0.0001), formal education (R2=8.3%, p< 0.0001); autonomy in hormonal therapy use (R=3.9%, p< 0.003); peri- post-menopausal knowledge (R2=2.1%, p< 0.001); diet (R2=1.6%, p< 0.006); peri- post-menopausal situation (R2=0.9%, p< 0.03). Conclusions: HPB were evaluated with sufficiency and these factors are very important in nursing care.
Factors associated with nursing diagnosis parental deterioration in mothers up to 24 years of age during the first year of rearing.
Authors: Orozco Luis Carlos , Pinilla Elvinia , Vargas Carolina , Buitrago Danuby Adriana , Domínguez Diana Beatriz , Peñaranda Liana Magreth , Reyes Diana María , Rueda Juliana
Published: July 2024

Introduction: At the present time the pregnancy in the young women is profiled as a problem in Latin America. There are many studies about gestation and the upbringing of the children of young mothers, but in Colombia there has not been yet one infirmary frame that specifically diagnoses the parental deterioration, the true relationship between mother-son and their influence in the presence of this diagnosis. Objective: To establish associated factors to the nursing infirmary diagnosis altered parenting (NANDA 3.2.1.1.1) in mothers until 24 years old, during the first year of upbringing. Materials and methods: It was a cross-sectional study in a sample of 240 women >24 years old that were in their first year of her last son’s upbringing. An instrument of 88 questions, as well as IPAA formats, self-esteem, social desires, and social support were applied; for the analysis of the information association measures OR and RR were also made through a bivaried analysis due to prevailing reasons and log binomial regression. The multivariable analysis was modelled with the logistical regression and RR was calculated according to Jun Zhang formula. Results: A prevalence of 24.3% to the diagnosis was found and in the final model 6 protective factors and 7 of risk were identified. Discussion: The main protective factor is the attendance to the prenatal controls and it became a fundamental tool, to decrease the parental deterioration diagnosis.
A present look of the symbols in nursing.
Authors: Burbano Consuelo
Published: July 2024

The historical investigation as well as a critical assessment of previous events related to nursing, reveal their effects on nursing present behaviours and practice. Nursing as science and discipline is constituted by memorable facts; nursing is the science of human existence in time; it comes from the past and goes to the future; as others sciences, it has been built slowly through three stages: knowledge, ethics, and aesthetics. The symbols of the oldest art and youngest profession -nursing should be orientated with critical sense and in accordance with current practices in the discipline.
Using biopsy for breast cancer diagnosis: an equity issue?.
Authors: De Charry Ligia Constanza , Roca Sandra , Carrasquilla Gabriel
Published: July 2024

Objetive: This study aims to evaluating whether health insurance status determines access to biopsy for diagnose of breast cancer among women in Colombia. Materials and methods: A retrospective follow-up study was carried out in women on treatment for breast cancer, selected from public and private institutions in six cities. A survey to collect information about health insurance status and economic, geographic, organizational and administrative barriers that might constrain access to diagnosis by biopsy was applied. To evaluate equity logistic regression model to calculate odds ratios to establish the association between health insurance status and putative barriers was used. Finally a multivariate analysis to control for confounding factors of women sociodemographic conditions was performed. Additionally interaction with their educative level and their residence location was evaluated. Results: Higher probabilities of barriers to biopsy in women with subsidized health insurance (OR 3.8 CI 95% 2.65-5.49) and for those without insurance (OR 4.9 CI 95% 3.00-7.99), compared to the insured women to face economic barriers for accessing diagnosis services for breast cancer were found. Also, women with health subsidized by the government together with those living in rural areas have a greater probability of geographic barriers (OR 2.0; CI 1.31-3.22) and (OR: 11.0 CI 95% 6.45-18.51) respectively. Conclusions: The study suggests that the use of diagnosis services for breast cancer is inequitable because the differences in probabilities affect the most vulnerable groups. The health insurance model may be responsible for this inequity.
Adolescence: bio-psychosocial changes and oral health.
Authors: Mafla Ana Cristina
Published: July 2024

Background: In dentistry, adolescents are an important reference group, since during this period the main dental and maxillary changes occur and their identity is consolidated, which will define their future attitude towards oral health. Methodology: In the years of 1997 through 2007, the National Center for Biotechnology PUBMED data base was searched for articles about adolescent bio-psychosocial features. The search was limited to articles in English and Spanish. Results: Hormonal changes increase weight, stature, muscular and bone mass, and include the acquisition of the secondary sexual characteristics. Regarding oral health, the incidence of dental caries and periodontal disease peaks during these years. In terms of psychosocial characteristics, adolescents solidify their identity in this time. There is an evolution from an auto-erotic focus to heterosexuality, show emotional fluctuations, vindicatory social attitudes, and there is a progressive separation from their parents and preferential association with their peers. These changes can lead to problems such as alcoholism, use of psychoactive substances and pregnancy. Conclusions: Adolescents undergo substantial physical and emotional changes. Adolescence is a critical age, for that reason it is important to pay special attention to it, as this period is complex and has an impact on several aspects of oral health. It would be valid to utilize the strategies practiced in other countries to help oral health outcomes during these years, i.e., the inclusion of teaching sessions on adolescence in health programs at university level.
Limits of bibliometrics indicators in biomedical scientific research evaluation.
Authors: Camps Diego
Published: July 2024

The use of bibliometrics indicators to study research activity is based on which the scientific publications are essential product of this activity, and provide information about the research process, its volume, evolution, visibility and structure. So, they allow to value the scientific activity, and influences (or impact) of the work and the sources. The bibliometrics studies, altogether with other indicators, allows an objective quantification of the knowledge, and are harnessed by the present explosion of the knowledge and its compilation in bibliographical data bases.
Osteoma cutis: a case report.
Authors: Sarmiento Pedro , Sinisterra Gustavo
Published: July 2024

The purpose of this comunication is to share the experience with a case of osteoma cutis in a 46 years old woman who requested odontological treatment at the dental clinic of the Universidad del Valle. The periapical radiographic image of the superior molar zone showed multiple radiopaque bilateral rounded bodies of approximately 2 mm in diameter. The case was further studied and analyzed at the radiological section of the school. It was characterized as a non-frequent radiological finding. This unusual finding motivated a detailed review and the use of other diagnostic tools, such as clinical and histopathological tests that established the final diagnosis.
Adverse drug reactions and adverse drug events in elderly patients consulting a hospital emergency unit.
Authors: Ocampo José Mauricio , Chacón José Arnoby , Gómez José Fernando , Curcio Carmen Lucía , Tamayo Francisco Javier
Published: July 2024

Objective: To determine adverse drug events (ADE) and adverse drug reactions (ADR) in elderly patients consulting a third level hospital emergency unit (EU). Design: Cross sectional study. Patients and methods: Four hundred patients aged sixty years or older consulting the EU (Caldas Hospital, Manizales, Colombia) (March-May 2004). Data on demographic characteristics, primary diagnosis, associated conditions and evaluation of medications intake were taken from the clinical records. Functional state was measured according with Barthel’s index. Type and severity of ADE and ADR were categorized. Algorithms were used for ADR operational assessment. Results: The mean of age of patients was 72.8±8.2 years, and 52.3% were females. Frequency of ADE and ADR was 6.8%. Organic systems affected were 48.1% gastrointestinal, 37% endocrine and metabolic. 28.3% of the patients were not on medication. Mean use of medications per patient was 2.9±1.7. Type of medications involved, in order of frequency, was antiplatelet, hypoglicemic, diuretic, NSAIDs and cardiovascular. Intake of medication (Odds Ratio (OR)=3.52, (IC95% =1.58-7.87), and functional status (OR=3.54 (IC95% = 1.6-7.82) were associated factors for emergency unit admission for ADE or ADR. In the logistic regression the presence of an associated illness constituted the only independent associated factor for hospitalization (OR=3.2 IC 95% 1.95-5.42). Conclusions: ADE and ADR are frequent, important and not well studied causes for consultation of elderly patients at the EU. The number of associated illness was the main risk factor for hospitalization by ADE or ADR.
Impact of a waste disposal site on children physical growth.
Authors: Ocampo Carmen Elisa , Pradilla Alberto , Méndez Fabián
Published: July 2024

Background: Several epidemiological studies have shown an increased risk of health problems among population living close to landfills. We evaluated the impact of a municipal solid waste disposal site on children’s growth between 0-3 years of age. Methods: Children were selected in sites likely to receive dispersion of air compounds from the waste disposal site and also in a control area, in Cali, Colombia, in 2005. Anthropometric measures were obtained at enrollment and in two follow-up visits at 3 months intervals to obtain standardized z scores of weight for height (WHZ) and height for age (HAZ). In addition, questionnaires including information of socio-economical conditions and morbidity were applied at enrolment and during follow-up visits. Results: Children exposed had on average 0.16 less standard deviations (SD) in WHZ scores when compared to control group (95% Confidence Interval [CI]: -0.34, 0.01). Among those who have lived >50% of their life in the study area, a significantly lower HAZ score was observed (-0.12) associated with exposure. Our data also suggest a larger effect of exposure to the waste disposal site in WHZ among children with symptoms of respiratory disease than among asymptomatic children (p=0.08). Conclusions: Exposure to this waste disposal site was found associated with lower children’s growth indexes.
Aislamiento de leptospiras en mamíferos salvajes en el Valle del Cauca
Authors: Medina Pablo , Arata Andrew A.
Published: July 2024

Se tomaron muestras de riñones y orina de animales salvajes capturados en las inmediaciones de las ciudades de Cali y Buenaventura, que fueron cultivadas para leptospiras. De las 124 muestras que no se contaminaron dos fueron positivas, una para L. Pomona, aislada de un murciélago, y otra para L. canicola, aislada de un roedor. Estos hallazgos pueden ser de importancia en la infección de humanos y de animales domésticos.
Blastomicosis suramericana en pulmones. Análisis clínico radiológico de 14 casos
Authors: Chamorro M. Carlos , Arguello Antonio , Sanchez V. Tito Javier
Published: July 2024

Se analizan 14 casos de blastomicosis suramericana de localización pulmonar, se hace énfasis en sus aspectos clínicos y sobre todo la localización de las lesiones mucocutáneas.
Se describen las características radiológicas en pulmones como son: bilateridad y simetría de las lesiones parenquimatosas nodulares, exudados alveolares y fibrosis, de la baja frecuencia de la cavitación, reacción pleural y calcificaciones de los infiltrados nodulares, finalmente se hace diagnóstico diferencial con algunas entidades que dan lesiones semejantes.
Aspectos psico-sociales del aborto provocado
Authors: Leon Carlos A. , De Vargas Cecilia
Published: July 2024

El presente trabajo consiste en la investigación de las posibles diferencias respecto a variables demográficas sociales y psicológicas entre un grupo de mujeres hospitalizadas por aborto inducido y otro de mujeres de edad comparable atendidas de parto a término.
Se trata pues, de un estudio controlado en el cual se comparan antecedentes familiares, antecedentes y prácticas sexuales, información sexual, actitudes y opiniones hacia el embarazo, aborto, parto y número de hijos. Para este propósito, se utilizó un cuestionario con preguntas abiertas.
Se hace un análisis estadístico de los resultados y se consignan comentarios y conclusiones.
Correspondencia
Authors: Chaux G. Aurelio , Cuello Carlos , Henao Hernán
Published: July 2024

Hemos tenido la oportunidad de ver y seguir al paciente con policondrosis Recurrente publicado en Acta Médica del Valle 2: 71-75, 1971.
La historia clínica de este paciente está clara y completamente descrita en la publicación hecha por agualimpia y colaboradores, por esta razon nos limitamos a describir la evolución del paciente, los hallazgos quirúrgicos y anatomopatológicos.
Conferencia Clínico Patológica
Authors: De Gaiter. Mercedes
Published: July 2024

Niña de raza mestiza, de 9 años de edad quien estuvo hospitalizada en 3 ocasiones en el Hospital Universitario del Valle.
Fué admitida por primera vez en Abril de 1971 con historia de cefalea intensa de 3 meses de evolución, que no cedía a los analgésicos comunes. Un mes antes había estado hospitalizada en el Club Noel durante 8 días por presentar vómito, color amarillento de la piel y parálisis facial. Se le hizo diagnóstico de hepatitis y recibió tratamiento
Experiencias parasitologicas de los estudiantes de medicina de la Universidad del Valle
Authors: Ayala Stephen C.
Published: July 2024

Los estudiantes del 4o año de Medicina de la Universidad del Valle presentaron el 3 de noviembre los resultados de sus investigaciones para el curso de parasitología médica. Se escogieron temas con buena probabilidad de producir resultados significativos dentro de los límites de tiempo del curso (2-6 semanas)
Sus contribuciones originales a conocimiento del parasitismo en nuestro medio. A continuación se presentan resúmenes de los trabajos presentados.
Tiene alguna utilidad la Historia Clinica
Authors: No especificado No especificado
Published: July 2024

Artículo sin abstract disponible
Un estudio de casos y controles para calcular el riesgo de eclampsia en Cali, Colombia
Authors: Neutra Raymond
Published: July 2024

Se compararon 220 pacientes eclámpticas de Cali y una muestra al azar de 345 parturientas de la población general, con el objeto de cuantificar el valor predictivo de 7 factores accesibles al obstetra en el comienzo del embarazo: edad, paridad, número de abortos y mortinatos previos, estado civil, clase social, y estado migratorio. Un segundo objeto fue calcular las tasas de eclampsia, tanto global como específica, por edad-paridad. La tasa global encontrada en Cali, 1.59 * 1000 nacidos vivos es de 2,5 veces mayor que la cifra correspondiente a jerusalén. La paridad y la edad tienen una relación muy estrecha con la eclampsia pero presentan un patrón distinto con la preeclampsia. Hay mayor riesgo de eclampsia para las madres solteras y para quienes tengan una historia de abortos previos. Cada uno de estos factores (edad, paridad, no casada y antecedente de aborto) es un componente independiente para predecir el riesgo de eclampsia. Un instrumento para calcular el riesgo, con base en estos factores, puede identificar un 12% de las mujeres que producen el 56% de las pacientes eclámpticas de Cali.
Distribution of polymorphism rs693 of ApoB gene in a sample of Colombian Caribbeans
Authors: Mendoza-Torres Evelyn , Pereira Sanandrés Nicole Samuel , Villarreal Camacho José Luis , Mendoza Xilene , De La Espriella César , Varela Prieto Lourdes Luz , VillanuevaTorregosa Daniel Antonio
Published: July 2024

Introduction: Several studies have reported that the single nucleotide polymorphism rs693 of Apo lipoprotein B gene is associated with high levels of plasma lipids and high body mass index, which are risk factors for cardiovascular diseases. The distribution of this single nucleotide polymorphism and its association with the phenotype depend on the genetic background of each population.
 Objective: To evaluate the distribution of single nucleotide polymorphism rs693 and its association with lipid profile and body mass index in a sample of Colombian Caribbeans.
 Methods: 108 non-related adult subjects of both gender were included in this study. Body mass index and lipid profile that included total cholesterol, triglycerides, Low Density Lipoprotein and High Density Lipoprotein were determined. The single nucleotide polymorphism rs693 was determined by Polymerase Chain Reaction/Restriction Fragment Length Polymorphism from genomic DNA followed by digestion with the restriction enzyme XbaI. The chi-square test was used to analyze the genotype distribution of rs693 and the genotype-phenotype association was evaluated through different inheritance model.
 Results: The genotype frequencies for single nucleotide polymorphism rs693 were CC (45.0%), TT (16.5%) and CT (38.5%). The allele frequencies were C (64.0%) and T (36.0%). The single nucleotide polymorphism was in Hardy-Weinberg equilibrium in the studied sample. No association of the single nucleotide polymorphism rs693 with lipid profile nor the body mass index was found (p >0.05).

Conclusion: There is no significant association between single nucleotide polymorphism rs693 and body mass index nor lipid profile, in a sample of Colombian Caribbeans.
Sobre la presencia de algunos artropodos en el área urbana de la ciudad de Cali, Valle
Authors: Barreto Pablo
Published: July 2024

Para determinar la composición de la fauna de artrópodos que existe en el perímetro urbano de la ciudad de Cali, se hicieron encuenstas entomológicas mediatne colecciones intradomiciliarias (lugares de reposo), capturas con cebo de luz (trampas de insectos) o con cebo humano y el examen directo de algunos animales domésticos. También se investigaron las formas inmaduras en criaderos potenciales.Ha sido posible reconocer grupos de artrópodos mnuy diversos que tienen interés en Salud Pública e importancia económica como transmisores de agentes patógenos o que constituyen una molestia por sí mismo debido al efecto local o general de sus picaduras. La lista incluye: escorpiones, garrapatas, ácaros, piojos, chinches, cucarachas, avispas, pulgas, mosquitos, jejenes, tábanos, moscas, etc. En ella se han incorporado los artrópodos informados en trabajos previos. Se discuten las relaciones entre algunos ejemplares encontrados y varias enfermedades.
Cáncer de laringe. Revisión clínica de 60 casos atendidos en el Hospital Universitario del Valle, Cali, 1964-1972
Authors: Blanco Pedro , Guzmán Ney
Published: July 2024

Se revisan las historias clínicas de 60 pacientes con Cáncer de Laringe que asistieron al Hospital Universitario del Valle desde el 1 de enero de 1964 al 31 de diciembre de 1972. El 76.7% de los tumores se diagnosticaron en personas mayores de 55 años. La relación hombre/mujer fue de 5:1; no se encontraron diferencias raciales. La frecuencia mayor de esta neoplasia en hombres se encontró asociada con el hábito de fumar cigarrillo.A pesar de cierta precocidad en consultar al médico después de iniciados los síntomas de la enfermedad, ésta se diagnostica en estados tumorales avanzados (62% con estados clínicamente III y IV). Una tasa de la letalidad alta se observó en esta serie. El tratamiento más común fue la laringectomía radical. La localización, extensión y comportamiento biológico de la lesión están relacionados con el pronóstico de la enfermedad.
Asociación del tipo y tiempo de inseminación durante el ciclo menstrual con la proporción de los sexos en el momento del nacimiento
Authors: Guerrero Rodrigo
Published: July 2024

Tomando el día del cambio de la temperatura basal como punto de referencia, se realizó un estudio sobre los eectos del momento y tipo de inseminación, en 1318 embarazos. Se encontró que la relación hombre-mujer (ínidce de masculinidad) se modificaba significativamente durante el ciclo menstrual tanto en la inseminación natural como en la artificial, aun cuando la tendencia era opuesta en los dos tipos de inseminación. En inseminación natural la proporción de varones disminuyó del 68%, para inseminaciones 6 o más días antes del aumento de temperatura, al 44% el día del alza. En inseminación artificial la proporción de varones aumentó de 39%, 3 o más días antes del aumento de temperatura, a 62% el día del alza. Los resultados ayudan a explicar los conflictos existentes en informes anteriores y sugieren que las diferencias ambientales afectan los espermatozoides X y Y.
Costo efecto de la instrucción programada en el adiestramiento de promotoras rurales
Authors: Rueda Beatriz , De James Ceneyda M , Johnson Ruth A
Published: July 2024

A 16 candidatras a Promotora Rural de Salud se las preparó alternando los métodos de la instrucción programa y clases tradicionales. En el análisis de los datos se comparó la efectividad de la instrucción programada y el método tradicional de clases por medio de un análisis de variaza de 2 criterios de clasificación con réplicas. El análisis de costo se hizo con base en costo capital y costo de operación. Los resultados mostraron que el método de instrucción programada empleado en el adiestramiento de promotoras de salud, es más efectivo que el tradicional. El método de instrucción proframada es menos costoso que el tradicional cuando se usan unidades de instrucción programada ya elaboradas.
Los datos de la historia clínica en la evaluación de sujetos violentos: Un estudio generador de hipótesis
Authors: Climent Carlos E , Ervin Frank R
Published: July 2024

Los datos obtenidos en la historia clínica de un grupo de pacientes que acudieron a la sala de urgencias por quejas de comportamiento violento (N=40), se compara con los datos de la historia clínica de un grupo de control (N=40), formado por familiares de otros pacientes de la sala de urgencias del mismo hospital. La comparación se hace sobre factores neurológicos, psiquiátricos y sociológicos seleccionados. Los resultados muestran: que el trauma craneano severo antes de la edad de 10 años no se asocia a un comportamiento violento en el adulto; que no hay diferencia apreciable con respecto a muchos rasgos neuróticos infantiles; que lo sujetos violentos reconocen un número mayor de pensamientos suicidas que los controles y que entre estos dos grupos no hay diferencias en la historia de criminalidad. Con base en estos resultados, se sugieren hipótesis específicas para estudios analíticos posteriores.
Púrpura Anafilactoide (Púrpura de Henosch-Schönlein)
Authors: Ramírez Germán
Published: July 2024

La púrpura anafilactoide o púrpura de Henosch-Schönlein, es una enfermedad de probable oriden inmunológico que compromete varios órganos y puede ocasionar falla renal crónica. Generalmente se presenta en nilos y más raras veces en adultos. Se caracteriza por 4 grupos de síntomas: lesiones cutáneas, artralgias, síntomas gastrointestinales y compromiso renal. De todos ellos, el compromiso renal es el más serio. El pronóstico es excelnte. En la actualidad no existe tratamiento específico.
Abstractos del IX Congreso de Ciencias Biológicas
Authors: Corredor Carlos
Published: July 2024

Los siguientes trabajos compartieron el premio "ITALMEX" para la mejor investigación en Ciencias Básicas Médicas
Agentes antitiroideos sintéticos y de origen natural
Authors: Gaitán Eduardo
Published: July 2024

Artículo sin abstract disponible
Infecciones agudas del sistema nerviosos central en niños de Cali, Colombia
Authors: Escobar Jorge A , Belsey Mark A , Dueñas Álvaro , Medina Pablo
Published: July 2024

Este estudio se diseño para mostrar la etiología, las características clínicas, el tratamiento y la evolución de las infecciones agudas del sistema nervioso central (SNC) en los niños de un país en desarrollo. De los 586 niños colombianos estudiados, en 215 se encontró meningitis bacteriana aguda (MBA), en 99 meningitis tuberculosa (MTB), y en 272 meningoencefalitis de etiologías no bacteria y no tuberculosa (no-MBA No-MBT). Llamó la atención la demora en la consulta, especialmente en los pacientes con MTB, y la alta tasa de mortalidad (32%) en estos niños que vienes de clases económicas bajas de la zona urbana.
Histerectomías innecesarias en Cali, 1972-1974
Authors: Cubillos Patricia , Aguilera Jorge H , Valencia César , Aguilera María Cecilia , Mejía Néstor , Molina Miguel , Delgado Jaime
Published: July 2024

Artículo sin abstract disponible
Nueva clasificación de niveles de atención quirúrgica
Authors: Vélez Adolfo , González Armando
Published: July 2024

Este estudio presenta una definición de operación quirúrgica y clasificación de las operaciones quirúrgicas, basada en cinco criterios.1. Personal 2. Anestesia 3. Instrumental, equipo y materiales 4. Tipo de sala de operaciones y 5. Hospitalización. Las operaciones quirúrgicas han sido divididas en cuatro niveles de atención quirúrgicas. Esta clasificación facilita la programación de los recursos necesarios para la solución de los problemas quirúrgicos. El presente trabajo hace parte de un estudio sistémico de los problemas quirúrgicos. El presente trabajo hace parte de un estudio sistemático de los problemas quirúrgicos del Valle del Cauca, en Colombia.
Cuarta unidad de autoinstrucción sobre electrocardiografía. Bloqueos de rama
Authors: Gutiérrez Javier
Published: July 2024

Artículo sin abstract disponible
Hallazgos clínicos, nutricionales y morfológicos intestinales en adultos asintomáticos del área rural
Authors: Mayoral Luis G , Caín J R , Bolaños Óscar , Falabella Francisco , Duque Édgar
Published: July 2024

Se investigaron 23 campesinos adultos asintomáticos, médicamente sanos y bioquímicamente bien nutridos. Los hallazgos fueron normales excepto por la presencia de anomalías mínimas en ciertos parámetros nutricionales. También hubo variaciones leves en la absorción de d-xilosa en algunos casos, y los balances nitrogenados estuvieron por encima de lo normal en otros. Se discuten los diferentes valores hallados y se sugiere que los datos consignados en el presente trabajo puedan servir de "controles" normales para estudios de nutrición en adultos del área rural colombiana.
Hepatitis anictérica después de anestesia breve con fluotano
Authors: De Lima Eduardo , Falabella Francisco , Tuffi García Fernando , Mayoral Luis Guillermo , Manzano Carlos
Published: July 2024

Artículo sin abstract disponible
Ganglion. Quiste sinovial de muñeca y mano
Authors: Gerstner Jochen
Published: July 2024

Artículo sin abstract disponible