bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating GAN-Based Image Augmentation for Threat Detection in Large-Scale Xray Security Images
Authors: Dumagpi Joanna Kazzandra , Jeong Yong-Jin
Published: December 2020

The inherent imbalance in the data distribution of X-ray security images is one of the most challenging aspects of computer vision algorithms applied in this domain. Most of the prior studies in this field have ignored this aspect, limiting their application in the practical setting. This paper investigates the effect of employing Generative Adversarial Networks (GAN)-based image augmentation, or image synthesis, in improving the performance of computer vision algorithms on an imbalanced X-ray dataset. We used Deep Convolutional GAN (DCGAN) to generate new X-ray images of threat objects and Cycle-GAN to translate camera images of threat objects to X-ray images. We synthesized new X-ray security images by combining threat objects with background X-ray images, which are used to augment the dataset. Then, we trained various Faster (Region Based Convolutional Neural Network) R-CNN models using different augmentation approaches and evaluated their performance on a large-scale practical X-ray image dataset. Experiment results show that image synthesis is an effective approach to combating the imbalance problem by significantly reducing the false-positive rate (FPR) by up to 15.3%. The FPR is further improved by up to 19.9% by combining image synthesis and conventional image augmentation. Meanwhile, a relatively high true positive rate (TPR) of about 94% was maintained regardless of the augmentation method used.
Barriers of Consumer Behavior for the Development of the Circular Economy: Empirical Evidence from Russia
Authors: Ratner Svetlana , Lazanyuk Inna , Revinova Svetlana , Gomonov Konstantin
Published: December 2020

This paper contributes to the literature on sustainable consumption by in-depth analysis of the factors affecting the probability of 57 different practices of proenvironmental behavior (PEBs) in Russia. The set of studied PEBs includes not only popular energy-saving and waste-management practices but also more circular patterns of plastic consumption, shopping, and city mobility. To study real and potential barriers to greening consumer behavior models, we conducted a survey of 623 respondents using a questionnaire developed based on a comparative analysis of similar studies conducted in other countries. The processing of the survey results was carried out using nonparametric statistics due to the absence of a normal distribution of the sample for most of the studied characteristics. The results of the study revealed that the main barriers to sustainable consumption in Russia are the lack of appropriate infrastructure as well as a lack of knowledge. Infrastructural barriers in some situations makes sustainable consumer behavior impossible or inconvenient (in this case, preference is given to other types of consumption), or in some cases necessitates spending additional time and money (then sustainable consumer behavior is not completely denied but practiced less often).
Model Predictive Control of Active Suspension for an Electric Vehicle Considering Influence of Braking Intensity
Authors: Zhang Junjiang , Yang Yang , Hu Minghui , Fu Chunyun , Zhai Jun
Published: December 2020

In the process of vehicle braking, braking intensity has a significant impact on vehicle comfort, and studies on this aspect have been limited. Therefore, an equivalent 4-degree-of-freedom half-vehicle model including the braking intensity influence was established in this study. Subsequently, considering braking intensity as the interference quantity that is the uncontrollable input, a model predictive control (MPC) strategy in which the vertical velocities of front body, rear body, front wheel, and rear wheel are the control targets was proposed. Based on Lyapunov’s stability theory, the stability of the MPC system was proven. Finally, a dual-loop control (DLC) strategy was used for comparison to verify the superiority of the MPC strategy. The results indicate that compared with the DLC strategy under the gradual braking condition, the root mean square of the front and rear body vertical velocities, body pitch angle, and body pitch angle velocity under the MPC strategy were all reduced by more than 70%, thus improving the ride comfort of the vehicle.
More on Pipelined Dynamic Scheduling of Big Data Streams
Authors: Souravlas Stavros , Anastasiadou Sofia , Katsavounis Stefanos
Published: December 2020

An important as well as challenging task in modern applications is the management and processing with very short delays of large data volumes. It is quite often, that the capabilities of individual machines are exceeded when trying to manage such large data volumes. In this regard, it is important to develop efficient task scheduling algorithms, which reduce the stream processing costs. What makes the situation more difficult is the fact that the applications as well as the processing systems are prone to changes during runtime: processing nodes may be down, temporarily or permanently, more resources may be needed by an application, and so on. Therefore, it is necessary to develop dynamic schedulers, which can effectively deal with these changes during runtime. In this work, we provide a fast and fair task migration policy while maintaining load balancing and low latency times. The experimental results have shown that our scheme offers better load balancing and reduces the overall latency compared to the state of the art strategies, due to the stepwise communication and the pipeline based processing it employs.
A Data-Driven Approach of Takagi-Sugeno Fuzzy Control of Unknown Nonlinear Systems
Authors: Zhang Bin , Shin Yung C.
Published: December 2020

A novel approach to build a Takagi-Sugeno (T-S) fuzzy model of an unknown nonlinear system from experimental data is presented in the paper. The neuro-fuzzy models or, more specifically, fuzzy basis function networks (FBFNs) are trained from input–output data to approximate the nonlinear systems for which analytical mathematical models are not available. Then, the T-S fuzzy models are derived from the direct linearization of the neuro-fuzzy models. The operating points for linearization are chosen using the evolutionary strategy to minimize the global approximation error so that the T-S fuzzy models can closely approximate the original unknown nonlinear system with a reduced number of linearizations. Based on T-S fuzzy models, optimal controllers are designed and implemented for a nonlinear two-link flexible joint robot, which demonstrates the possibility of implementing the well-established model-based optimal control method onto unknown nonlinear dynamic systems.
Effect of Paper Sludge and Dendromass on Properties of Phytomass Pellets
Authors: Nosek Radovan , Backa Alexander , Ďurčanský Peter , Holubčík Michal , Jandačka Jozef
Published: December 2020

Woody and agricultural wastes are important fuels in many countries, and have the potential of being even more important in the future. The main problems of plant biomass combustion are low ash melting temperatures and increased emissions. The most widely used treatment to solve the problem of low ash melting point is blending a fuel with an additive. In this work, pellets were produced from wheat straw containing wood sawdust and paper sludge in the following proportions 40:40:20 and 45:45:10 (straw/sawdust/paper sludge). The purpose of this work was to study the influence of sludge and dendromass on the straw pellet parameters and combustion process. The highest calorific value of 15.71 MJ kg−1 was registered for a sample with a 10% paper sludge concentration. The effectiveness of paper sludge was proved, and the ash melting temperature was increased from 1025 to 1328 °C for the same sample.
Cyanobacterial Potential for Restoration of Loess Surfaces through Artificially Induced Biocrusts
Authors: Palanački Malešević Tamara , Dulić Tamara , Obreht Igor , Trivunović Zorana , Marković Rastko , Kostić Bojan , Važić Tamara , Meriluoto Jussi , Svirčev Zorica
Published: December 2020

Loess is a highly porous and easily erosive aeolian sediment covering approximately 10% of the Earth’s surface. The weak vegetation cover and high wind speeds in many of these regions make loess sediment the main source of dust in the atmosphere. Dust particles deteriorate air quality and affect soils, crops, water systems, and animal and human health. The commonly used method for combating desertification is revegetation. However, planting various vascular plant species in loess landscapes did not show any long-lasting positive effects. This study aims to assess the potential of cyanobacterial strains for the restoration of exposed loess surfaces through the assisted development of biological loess crusts (BLCs). Isolated cyanobacterial loess strains were screened for the traits (toxicity, biomass and polysaccharide production) desirable for their use in restoration purposes. By simulating semi-arid environmental conditions in specially designed chambers, the potential of cyanobacterial loess strains for assisted development of BLCs and the mechanisms of loess stabilization have been evaluated by chlorophyll a accumulation and microscopic examination. It was confirmed that cyanobacteria have the ability to interact with loess particles resulting in BLC formation, which keeps the particles immobilized and the sediment below the particles stabilized.
Atmospheric Aqueous-Phase Chemistry
Authors: Grgić Irena
Published: December 2020

The Atmosphere Special Issue “Atmospheric Aqueous-Phase Chemistry” comprises ten original articles dealing with different aspects of chemistry in atmospheric liquid water. [...]
Projected Hydroclimate Changes on Hispaniola Island through the 21st Century in CMIP6 Models
Authors: Herrera Dimitris A. , Mendez-Tejeda Rafael , Centella-Artola Abel , Martínez-Castro Daniel , Ault Toby , Delanoy Ramón
Published: December 2020

Climate change might increase the frequency and severity of longer-lasting drought in the Caribbean, including in Hispaniola Island. Nevertheless, the hydroclimate changes projected by the state-of-the-art earth system models across the island remain unknown. Here, we assess 21st-century changes in hydroclimate over Hispaniola Island using precipitation, temperature, and surface soil moisture data from the 6th Phase of the Coupled Model Intercomparison Project (CMIP6). The resulting analysis indicates, as with the previous 5th Phase of CMIP (CMIP5) models, that Hispaniola Island might see a significant drying through the 21st century. The aridity appears to be robust in most of the island following the Shared Socioeconomic Pathways (SSP) 5–8.6, which assumes the “worst case” greenhouse gas emissions into the atmosphere. We find a significant reduction in both annual mean precipitation and surface soil moisture (soil’s upper 10 cm), although it appears to be more pronounced for precipitation (up to 26% and 11% for precipitation and surface soil moisture, respectively). Even though we provide insights into future hydroclimate changes on Hispaniola Island, CMIP6’s intrinsic uncertainties and native horizontal resolution precludes us to better assess these changes at local scales. As such, we consider future dynamical downscaling efforts that might help us to better inform policy-makers and stakeholders in terms of drought risk.
Drug Repurposing Approach against Novel Coronavirus Disease (COVID-19) through Virtual Screening Targeting SARS-CoV-2 Main Protease
Authors: Chowdhury Kamrul Hasan , Chowdhury Md. Riad , Mahmud Shafi , Tareq Abu Montakim , Hanif Nujhat Binte , Banu Naureen , Reza A. S. M. Ali , Emran Talha Bin , Simal-Gandara Jesus
Published: December 2020

Novel coronavirus disease (COVID-19) was identified from China in December 2019 and spread rapidly through human-to-human transmission, affecting so many people worldwide. Until now, there has been no specific treatment against the disease and repurposing of the drug. Our investigation aimed to screen potential inhibitors against coronavirus for the repurposing of drugs. Our study analyzed sequence comparison among SARS-CoV, SARS-CoV-2, and MERS-CoV to determine the identity matrix using discovery studio. SARS-CoV-2 Mpro was targeted to generate an E-pharmacophore hypothesis to screen drugs from the DrugBank database having similar features. Promising drugs were used for docking-based virtual screening at several precisions. Best hits from virtual screening were subjected to MM/GBSA analysis to evaluate binding free energy, followed by the analysis of binding interactions. Furthermore, the molecular dynamics simulation approaches were carried out to assess the docked complex’s conformational stability. A total of 33 drug classes were found from virtual screening based on their docking scores. Among them, seven potential drugs with several anticancer, antibiotic, and immunometabolic categories were screened and showed promising MM/GBSA scores. During interaction analysis, these drugs exhibited different types of hydrogen and hydrophobic interactions with amino acid residue. Besides, 17 experimental drugs selected from virtual screening might be crucial for drug discovery against COVID-19. The RMSD, RMSF, SASA, Rg, and MM/PBSA descriptors from molecular dynamics simulation confirmed the complex’s firm nature. Seven promising drugs for repurposing against SARS-CoV-2 main protease (Mpro), namely sapanisertib, ornidazole, napabucasin, lenalidomide, daniquidone, indoximod, and salicylamide, could be vital for the treatment of COVID-19. However, extensive in vivo and in vitro studies are required to evaluate the mentioned drug’s activity.
Visual System Impairment in a Mouse Model of Krabbe Disease: The Twitcher Mouse
Authors: Tonazzini Ilaria , Cerri Chiara , Del Grosso Ambra , Antonini Sara , Allegra Manuela , Caleo Matteo , Cecchini Marco
Published: December 2020

Krabbe disease (KD, or globoid cell leukodystrophy; OMIM #245200) is an inherited neurodegenerative condition belonging to the class of the lysosomal storage disorders. It is caused by genetic alterations in the gene encoding for the enzyme galactosylceramidase, which is responsible for cleaving the glycosydic linkage of galatosylsphingosine (psychosine or PSY), a highly cytotoxic molecule. Here, we describe morphological and functional alterations in the visual system of the Twitcher (TWI) mouse, the most used animal model of Krabbe disease. We report in vivo electrophysiological recordings showing defective basic functional properties of the TWI primary visual cortex. In particular, we demonstrate a reduced visual acuity and contrast sensitivity, and a delayed visual response. Specific neuropathological alterations are present in the TWI visual cortex, with reduced myelination, increased astrogliosis and microglia activation, and around the whole brain. Finally, we quantify PSY content in the brain and optic nerves by high-pressure liquid chromatography-mass spectrometry methods. An increasing PSY accumulation with time, the characteristic hallmark of KD, is found in both districts. These results represent the first complete characterization of the TWI visual system. Our data set a baseline for an easy testing of potential therapies for this district, which is also dramatically affected in KD patients.
Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings
Authors: Lewandowska Paulina , Wierzbicki Jaroslaw , Zawadzki Marek , Agrawal Anil , Krzystek-Korpacka Małgorzata
Published: December 2020

Facilitating resolution of inflammation using atypical chemokine receptors (ACKR) as an anticancer strategy is considered but requires a deeper understanding of receptor role in carcinogenesis. We aimed at transcriptional analysis (RTqPCR) of ACKR2 and ACKR4 expression in colorectal adenoma-adenocarcinoma sequence in paired normal-neoplastic tissues from 96 polyps and 51 cancers. On average, ACKR2 was downregulated in neoplastic as compared to non-affected tissue in polyp (by 2.7-fold) and cancer (by 3.1-fold) patients. The maximal downregulation (by 8.2-fold) was observed in adenomas with the highest potential for malignancy and was gradually lessening through cancer stages I-IV, owing to increased receptor expression in tumors. On average, ACKR4 was significantly downregulated solely in adenocarcinomas (by 1.5-fold), less so in patients with lymph node metastasis, owing to a gradual decrease in ACKR4 expression among N0-N1-N2 cancers in non-affected tissue without changes in tumors. In adenomas, ACKR4 downregulation in neoplastic tissue increased with increasing potential for malignancy and contribution of villous growth pattern. ACKR4 expression increased in non-affected tissue with a concomitant decrease in pathological mucosa. In conclusion, the changes in ACKRs expression occur already in precancerous colorectal lesions, culminating in the adenomas with the highest potential for malignancy. Therefore, chemoprevention by manipulating ACKRs’ expression is worth exploration.
ALDREN: A Methodological Framework to Support Decision-Making and Investments in Deep Energy Renovation of Non-Residential Buildings
Authors: Sesana Marta , Salvalai Graziano , Brutti Diletta , Mandin Corinne , Wei Wenjuan
Published: December 2020

Since 2002, the Energy Performance of Buildings Directive (EPBD) has set up the path to improve the efficiency gains in the EU building sector, including measures that should accelerate the rate of building renovation towards more energy efficient systems. Under the 2010 EPBD, all EU countries have established independent energy performance certification systems supported by independent mechanisms of control and verification. The EU directive 2018/844 has introduced different novelties and one of these regards the possibility for the Member States, together with the Long-Term Renovation Strategies (LTRS), to introduce an optional Building Renovation Passport Article 2a.1(c), considered as an empowering document that gives more reliable and independent information on the potential for energy savings that is tied up in their buildings. On 14 October 2020, the European Commission launched its Communication and Strategy on the Renovation Wave initiative, intending to double the current Europe’s renovation rate to make the continent carbon neutral by 2050. However, current practices and tools of energy performance assessment and certification applied across Europe face several challenges. In this context, the ALDREN project is a methodological framework that aims to support decision-making and investment in deep energy renovation of nonresidential buildings, based on a set of procedures (modules) that consist in the step-by-step implementation of protocols to assess the energy performance, indoor environmental quality, and financial value of buildings, before and after the energy renovation. The paper presents the ALDREN overall procedure with a focus on the development of the Building Renovation Passport and its application to an Italian office building.
Adsorption and Photocatalytic Mineralization of Bromophenol Blue Dye with TiO2 Modified with Clinoptilolite/Activated Carbon
Authors: Kweinor Tetteh Emmanuel , Rathilal Sudesh
Published: December 2020

This study presents a hybridized photocatalyst with adsorbate as a promising nanocomposite for photoremediation of wastewater. Photocatalytic degradation of bromophenol blue (BPB) in aqueous solution under UV-irradiation of wavelength 400 nm was carried out with TiO2 doped with activated carbon (A) and clinoptilolite (Z) via the co-precipitation technique. The physiochemical properties of the nanocomposite (A–TiO2 and Z–TiO2) and TiO2 were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared (FTIR) spectroscopy. Results of the nanocomposite (A–TiO2 and Z–TiO2) efficiency was compared to that with the TiO2, which demonstrated their adsorption and synergistic effect for the removal of chemical oxygen demand (COD) and color from the wastewater. At an optimal load of 4 g, the photocatalytic degradation activity (Z–TiO2 > A–TiO2 > TiO2) was found favorably by the second-order kinetic model. Consequently, the Langmuir adsorption isotherms favored the nanocomposites (Z–TiO2 > A–TiO2), whereas that of the TiO2 fitted very well on the Freundlich isotherm approach. Z–TiO2 evidently exhibited a high photocatalytic efficacy of decomposition over 80% of BPB (COD) at reaction rate constant (k) and coefficient of determination (R2) values of 5.63 × 10−4 min−1 and 0.989, respectively.
Carbon Dots as a Sustainable New Platform for Organic Light Emitting Diode
Authors: Lagonegro Paola , Giovanella Umberto , Pasini Mariacecilia
Published: December 2020

Over the past 10 years, carbon dots (CDs) synthesized from renewable raw materials have received considerable attention in several fields for their unique photoluminescent properties. Moreover, the synthesis of CDs fully responds to the principles of circular chemistry and the concept of safe-by-design. This review will focus on the different strategies for incorporation of CDs in organic light-emitting devices (OLEDs) and on the study of the impact of CDs properties on OLED performance. The main current research outcomes and highlights are summarized to guide users towards full exploitation of these materials in optoelectronic applications.
Intramolecular Hydrogen Bond Energy and Its Decomposition—O–H∙∙∙O Interactions
Authors: Grabowski Sławomir
Published: December 2020

The method to calculate the energy of intramolecular hydrogen bond is proposed and tested for a sample of malonaldehyde and its fluorine derivatives; the corresponding calculations were performed at the ωB97XD/aug-cc-pVTZ level. This method based on relationships found for related intermolecular hydrogen bonds is compared with other approaches which may be applied to estimate the intramolecular hydrogen bond energy. Particularly, methods based on the comparison of the system that contains the intramolecular hydrogen bond compared with corresponding conformations where such interaction does not occur are discussed. The function-based energy decomposition analysis, FB-EDA, of the intramolecular hydrogen bonds is also proposed here.
Design of a Compact and Highly Efficient Energy Harvester System Suitable for Battery-Less Low Cost On-Board Unit Applications
Authors: Collodi Giovanni , Maddio Stefano , Pelosi Giuseppe
Published: December 2020

This study addresses the general problem regarding the power supply in specific on-board unit (OBUs) solutions. In detail, this paper refers to a subset of the so-called electronic toll collection (ETC) applications such as assets control and vehicle identification, where simplicity, low costs, and maximum compactness represent the most important features. In this context, the next generation of OBUs, developed specifically with reference to such applications, will involve energy harvester-based battery-less techniques. Previous studies have mainly concentrated on performance optimization by achieving maximum energy transmission to the OBUs. This study discusses a technique suitable for both maximizing performance and minimizing the dimensions of transponder energy harvesters suitable for assets control and vehicle identification operating at 5.8 GHz. The technique assumes that an optimal source impedance exists that maximizes the energy transfer to the transponder, thus enabling its power supply in a battery-less configuration. We discuss a solution based on a compact patch antenna designed to exhibit this optimal source impedance to the RF-to-DC rectifier. This approach avoids the use of a lossy matching network. For the sake of comparison, the same function is compared with an equivalent development, which includes the interstage matching network between the antenna and the RF-to-DC rectifier. We introduce experimental results demonstrating that the ultracompact energy harvester optimized at −5 dBm of impinging power is capable of increasing both the charge current and energy efficiency from 340 to 450 μA and from 37% to 47%, respectively.
Homeopathy and Psychological Therapies
Authors: Donelli Davide , Antonelli Michele
Published: December 2020

Homeopathy is a popular, although highly debated, medicinal practice based on the administration of remedies in which active substances are so diluted that no detectable trace of them remains in the final product. This hypothesis paper aims to outline a possible reinterpretation of homeopathy in the light of psychological therapies in order to improve its clinical safety and sustainability.
The Influence of Increased Salvage Felling on Forwarding Distance and the Removal—A Case Study from Croatia
Authors: Đuka Andreja , Bumber Zoran , Poršinsky Tomislav , Papa Ivica , Pentek Tibor
Published: December 2020

During the seven-year research period, the average annual removal was by 3274 m3 higher than the average annual removal prescribed by the existing management plan (MP). The main reason lies in the high amount of salvage felling volume at 55,238 m3 (38.3%) in both the main and the intermediate felling due to oak dieback. The analysis of forest accessibility took into account the spatial distribution of cutblocks (with ongoing felling operations) and the volume of felled timber for two proposed factors: (1) the position of the cutblock and (2) the position of the removal. Cutblock position factor took into account the spatial position of the felling areas/sites, while removal position factor besides the spatial reference took into account the amount of felled timber (i.e., volume) both concerning forest infrastructure network and forest operations. The analysed relative forest openness by using geo-processing workflows in GIS environment showed four types of opening areas in the studied management unit (MU): single-opened, multiple-opened, unopened and opened areas outside of the management unit. Negative effects of the piece-volume law and low harvesting densities on forest operations are highlighted in this research due to high amount of salvage felling particularly in the intermediate felling by replacing timber volume that should have come from thinnings.
Lipid Compositions and Geographical Discrimination of 94 Geographically Authentic Wheat Samples Based on UPLC-MS with Non-Targeted Lipidomic Approach
Authors: Jin Mengchu , Zheng Wenhao , Zhang Yaqiong , Gao Boyan , Yu Liangli (Lucy)
Published: December 2020

Wheat is the staple food for the world’s major populations. However, chemical characters of geographically authentic wheat samples, especially for the lipids, have not been deeply studied. The present research aimed to investigate lipid compositions of Chinese wheat samples and clarify the major markers that contribute to the geographical differences. A total of 94 wheat samples from eight main wheat-producing provinces in China were evaluated to differentiate their lipid compositions. Based on the data collected from ultra-high-performance-liquid-chromatography tandem time-of-flight mass spectrometry (UPLC-Q/TOF MS), an optimized non-targeted lipidomic method was utilized for analyses. As the results, 62 lipid compounds, including fatty acids, phospholipids, galactolipids, triglycerides, diglycerides, alkylresorcinol, and ceramide were tentatively identified. Partial least squares discriminant analysis (PLS-DA) demonstrated a more satisfying performance in distinguishing wheat samples from different origins compared with principal component analysis (PCA). Further, the abundances of triglycerides and glycerophospholipids with more unsaturated fatty acids were found greater in wheat samples from northern origins of China, while more glycolipids and unsaturated fatty acids arose in southern original wheat samples. These findings describe the lipid profiles of wheat samples in China and could contribute to the quality and safety control for the wheat flour products.
Citrinin in Foods and Supplements: A Review of Occurrence and Analytical Methodologies
Authors: Silva Liliana J. G. , Pereira André M. P. T. , Pena Angelina , Lino Celeste M.
Published: December 2020

Citrinin (CIT) deserves attention due to its known toxic effects in mammalian species and its widespread occurrence in food commodities, often along with ochratoxin A, another nephrotoxic mycotoxin. Human exposure, a key element in assessing risk related to food contaminants, depends upon mycotoxin contamination levels in food and on food consumption. Commercial supplements, commonly designated as red rice, usually used in daily diets in Asiatic countries due to their medicinal properties, may pose a health problem as a result of high CIT levels. In addition to the worldwide occurrence of CIT in foods and supplements, a wide range of several analytical and detection techniques with high sensitivity, used for evaluation of CIT, are reviewed and discussed in this manuscript. This review addresses the scientific literature regarding the presence of CIT in foods of either vegetable or animal origin, as well as in supplements. On what concerns analytical methodologies, sample extraction methods, such as shaking extraction and ultrasonic assisted extraction (UAE), clean-up methods, such as liquid-liquid extraction (LLE), solid phase extraction (SPE) and Quick, Easy, Cheap, Effective, Rugged and Safe (QuECHERS), and detection and quantification methods, such as thin layer chromatography (TLC), high performance liquid chromatography (HPLC), capillary electrophoresis (CE), biosensors, and ELISA, are also reviewed.
Postcolonial Islam in My Son the Fanatic: From Deobandi Revivalism to the Secular Transposition of the Sufi Imaginary
Authors: Scott Jamie S.
Published: December 2020

Set in the early 1990s, Hanif Kureishi’s short story “My Son the Fanatic” (1997) dramatizes tensions between Parvez, a lapsed Pakistani Muslim migrant to postcolonial England, and his son Ali, who rejects the western secularity of his father and reverts to a strict form of fundamentalist Islam. If these tensions remain unresolved in the story, Kureishi’s film adaptation elaborates them. In so doing, though, My Son the Fanatic (dir. Udayan Prasad 1997) presents a very different picture. Renamed Farid, the film’s eponymous youth breaks off engagement to the daughter of the local chief of police and challenges his father: “Can you put keema [minced meat] with strawberries?” Metaphorically, this question articulates the deeper concern underlying the story: How might migrants in diaspora live an authentic Muslim life in the secular environment of the predominantly non-Muslim United Kingdom? A close reading of My Son the Fanatic reveals vying answers. Farid and Parvez both invoke the Qur’an, ultimate arbiter of value, meaning and truth in Islam, but thence their paths diverge widely. On the one hand, the film depicts the revivalist maslak of Deobandi Islam, though such missionary fervour may lead all too easily to the violent militancy of Farid and his cohort. On the other hand, My Son the Fanatic suggests conditions of possibility for a Muslim life of sacralised secularity by developing the love between Parvez and Sandra in terms of tropes and themes transposed from the Sufi imaginary to the postcolonial United Kingdom, most notably an ethos of iḥsān, that is, the cultivation of what is beautiful and good.
Effects of Deep Dry Needling on Tremor Severity and Functionality in Stroke: A Case Report
Authors: Ortín José Antonio , Bravo-Esteban Elisabeth , Ibáñez Jaime , Herrero Pablo , Gómez-Soriano Julio , Marcén-Román Yolanda
Published: December 2020

This study aimed to determine the effect of one session of dry needling on the severity of tremor, motor function and skills, and quality of life of a 39-year-old woman with post-stroke tremor. Myofascial trigger points (MTrP) of the following muscles were treated: extensor digitorum, flexor digitorum superficialis and profundus, brachioradialis, short head of biceps brachii, long head of triceps brachii, mid deltoid, infraspinatus, teres minor, upper trapezius, and supraspinatus. Outcomes were assessed via (i) clinical scales (activity of daily living (ADL-T24), a visual analog scale (VAS), and the Archimedes spiral), (ii) a functional test (9-Hole Peg test), and (iii) biomechanical and neurophysiological measurements (inertial sensors, electromyography (EMG), and dynamometry). The subject showed a decrease in the severity of tremor during postural (72.7%) and functional (54%) tasks after treatment. EMG activity decreased after the session and returned to basal levels 4 days after. There was an improvement post-intervention (27.84 s) and 4 days after (32.43 s) in functionality and manual dexterity of the affected limb, measured with the 9-Hole Peg test, as well as in the patient’s hand and lateral pinch strength after the treatment (26.9% and 5%, respectively), that was maintained 4 days later (15.4% and 16.7%, respectively).
Data Analysis Model Design of Health Service Monitoring System for China’s Elderly Population: The Proposal of the F-W Model Based on the Collaborative Governance Theory of Healthy Aging
Authors: Fu Liping , Teng Tao , Wang Yuhui , He Lanping
Published: December 2020

In the era of artificial intelligence, big data and 5G, health care for elderly people is facing an important digital transformation. The objective of this study is to design the data analysis module of the elderly health service monitoring system (HSMS) and attempt to put forward a new healthy aging (HA) model that is applicable not only to the individual HA, but also to the regional HA system. Based on the HA theory of collaborative governance, we divided the elderly HSMS into four modules, including physical health, mental health, ability of daily activity, and social participation. Then, factors that influence HA were assessed by stepwise logistic regression to build the analysis model, using the public micro-panel data of the China Health and Retirement Longitudinal Survey (CHARLS). Age (odds ratio (OR) = 1.55 (95% confidence interval (CI): 1.06–2.27)), living in urban areas (OR = 1.57 (95% CI: 1.03–2.39)), being literate (OR = 1.51 (95% CI: 1.01–2.23)), expecting to get long-term health care in the future from their grown children (OR = 1.69 (95% CI: 1.10–2.61)) and having literate grown children (OR = 2.01 (95% CI: 0.26–0.97)) had a significant positive impact on HA of elderly people. Therefore, the F-W (factors and weighs, also family and welfare) model is proposed in this paper. The outcomes can contribute with designing HSMS for different provinces and several different regions in China and leave a door open to improve the model and algorithm application for HSMS in the future studies.
Proteomic Analyses Detect Higher Expression of C-Type Lectins in Imidacloprid-Resistant Colorado Potato Beetle Leptinotarsa decemlineata Say
Authors: Scott Ian M. , Hatten Gabrielle , Tuncer Yazel , Clarke Victoria C. , Jurcic Kristina , Yeung Ken K.-C.
Published: December 2020

The Colorado potato beetle (CPB) is one of the most adaptable insect pests to both plant toxins and synthetic insecticides. Resistance in CPB is reported for over 50 classes of insecticides, and mechanisms of insecticide-resistance include enhanced detoxification enzymes, ABC transporters and target site mutations. Adaptation to insecticides is also associated with changes in behaviour, energy metabolism and other physiological processes seemingly unrelated to resistance but partially explained through genomic analyses. In the present study, in place of genomics, we applied 2-dimensional (2-D) gel and mass spectrometry to investigate protein differences in abdominal and midgut tissue of insecticide-susceptible (S) and -resistant (R) CPB. The proteomic analyses measured constitutive differences in several proteins, but the highest match was identified as a C-type lectin (CTL), a component of innate immunity in insects. The constitutive expression of the CTL was greater in the multi-resistant (LI) strain, and the same spot was measured in both midgut and abdominal tissue. Exposure to the neonicotinoid insecticide, imidacloprid, increased the CTL spot found in the midgut but not in the abdominal tissue of the laboratory (Lab) strain. No increase in protein levels in the midgut tissue was observed in the LI or a field strain (NB) tolerant to neonicotinoids. With the exception of biopesticides, such as Bacillus thuringiensis (Bt), no previous studies have documented differences in the immune response by CTLs in insects exposed to synthetic insecticides or the fitness costs associated with expression levels of immune-related genes in insecticide-resistant strains. This study demonstrates again how CPB has been successful at adapting to insecticides, plant defenses as well as pathogens.
Real-World Experience with Bezlotoxumab for Prevention of Recurrence of Clostridioides difficile Infection
Authors: Escudero-Sánchez Rosa , Ruiz-Ruigómez María , Fernández-Fradejas Jorge , García Fernández Sergio , Olmedo Samperio María , Cano Yuste Angela , Valencia Alijo Angela , Díaz-Pollán Beatriz , Rodríguez Hernández María , Merino De Lucas Esperanza , Martín Segarra Oriol , Sáez Bejar Carmen , Armiñanzas Castillo Carlos , Gutiérrez-Gutiérrez Belén , Rodríguez-Pardo Dolors , Ramos-Martínez Antonio , Torre-Cisneros Julián , López-Medrano Francisco , Cobo Reinoso Javier
Published: December 2020

Bezlotoxumab is marketed for the prevention of recurrent Clostridioides difficile infection (rCDI). Its high cost could be determining its prescription to a different population than that represented in clinical trials. The objective of the study was to verify the effectiveness and safety of bezlotoxumab in preventing rCDI and to investigate factors related to bezlotoxumab failure in the real world. A retrospective, multicentre cohort study of patients treated with bezlotoxumab in Spain was conducted. We compared the characteristics of cohort patients with those of patients treated with bezlotoxumab in the pivotal MODIFY trials. We assessed recurrence rates 12 weeks after completion of treatment against C. difficile, and we analysed the factors associated with bezlotoxumab failure. Ninety-one patients were included in the study. The cohort presented with more risk factors for rCDI than the patients included in the MODIFY trials. Thirteen (14.2%) developed rCDI at 12 weeks of follow-up, and rCDI rates were numerically higher in patients with two or more previous episodes (25%) than in those who had fewer than two previous episodes of C. difficile infection (CDI) (10.4%); p = 0.09. There were no adverse effects attributable to bezlotoxumab. Despite being used in a more compromised population than that represented in clinical trials, we confirm the effectiveness of bezlotoxumab for the prevention of rCDI.
Underwater Pipe and Valve 3D Recognition Using Deep Learning Segmentation
Authors: Martin-Abadal Miguel , Piñar-Molina Manuel , Martorell-Torres Antoni , Oliver-Codina Gabriel , Gonzalez-Cid Yolanda
Published: December 2020

During the past few decades, the need to intervene in underwater scenarios has grown due to the increasing necessity to perform tasks like underwater infrastructure inspection and maintenance or archaeology and geology exploration. In the last few years, the usage of Autonomous Underwater Vehicles (AUVs) has eased the workload and risks of such interventions. To automate these tasks, the AUVs have to gather the information of their surroundings, interpret it and make decisions based on it. The two main perception modalities used at close range are laser and video. In this paper, we propose the usage of a deep neural network to recognise pipes and valves in multiple underwater scenarios, using 3D RGB point cloud information provided by a stereo camera. We generate a diverse and rich dataset for the network training and testing, assessing the effect of a broad selection of hyperparameters and values. Results show F1-scores of up to 97.2% for a test set containing images with similar characteristics to the training set and up to 89.3% for a secondary test set containing images taken at different environments and with distinct characteristics from the training set. This work demonstrates the validity and robust training of the PointNet neural in underwater scenarios and its applicability for AUV intervention tasks.
Presence of Polyphenols Complex Aromatic “Lignin” in Sargassum spp. from Mexican Caribbean
Authors: Alzate-Gaviria Liliana , Domínguez-Maldonado Jorge , Chablé-Villacís Rubí , Olguin-Maciel Edgar , Leal-Bautista Rosa María , Canché-Escamilla Gonzalo , Caballero-Vázquez Adán , Hernández-Zepeda Cecilia , Barredo-Pool Felipe Alonso , Tapia-Tussell Raúl
Published: December 2020

In recent years, the massive influx of pelagic Sargassum spp. has generated great interest in the scientific community, highlighting the urgency of addressing the physiology and biochemical composition of these species. Until now, the presence of lignified cells in the tissue of Sargassum natans and Sargassum fluitans has not been reported. Although ‘‘lignin-like’’ compounds have been identified in green algae, the presence of true lignin in the Sargassum genus has not been confirmed. Our work is the first report of lignified cells forming the secondary cell wall in these Sargassum. This study used histological techniques applied to thick sections for identifying lignin-like tissues in Sargassum spp. The dyes as Safranin O and Toluidine have been used to differentiate lignin and cellulose in conducting tissue and to indicate the presence, absence, and distribution of these compounds in tissues. This work is the initial study of the cell wall heteropolymers structure and arrangement in Sargassum spp., providing insights into the unique cell wall architecture of these seaweeds.
Novel Comprehensive Molecular and Ecological Study Introducing Coastal Mud Shrimp (Solenocera Crassicornis) Recorded at the Gulf of Suez, Egypt
Authors: Abbas Eman M. , Ali Fawzia S. , Desouky Mohammed G. , Ashour Mohamed , El-Shafei Ahmed , Maaty Mahmoud M. , Sharawy Zaki Z.
Published: December 2020

Solenocera crassicornis is a commercially important shrimp of the Solenoceridae family. The current study investigated the morphology, molecular identification, phylogenetic relationships, and population dynamics of S. crassicornis in Egypt. Samples were collected monthly (total, 1722; male = 40.19%, wet weight, 0.89–10.77 g; female = 59.81%, wet weight, 1.55–19.24 g) from Al-Attaka commercial catch in the Gulf of Suez in the Red Sea. Two barcode markers, 18S rRNA and cytochrome c oxidase subunit I (COI), were used for molecular identification. COI partial sequences were used to construct the phylogenetic relationships among different species of genus Solenocera and to infer the origin of the studied Solenocera crassicornis. The applied molecular markers successfully identified the studied species to the species level. The genetic distances among S. crassicornis sequences from different countries revealed the Indo-West Pacific origin of S. crassicornis. The relationship between total length (TL) and total weight (TW) was TW = 0.035TL2.275 and r2 = 0.805 for males and TW = 0.007TL3.036 and r2 = 0.883 for females, indicating that females were heavier than males. Despite its social and economic relevance in the area, information on the hatching, larval rearing, and farming of S. crassicornis is scarce and requires future studies under Egyptian conditions.
Estimated Burden of Fungal Infections in Oman
Authors: Al-Hatmi Abdullah M. S. , Al-Shuhoumi Mohammed A. , Denning David W.
Published: December 2020

For many years, fungi have emerged as significant and frequent opportunistic pathogens and nosocomial infections in many different populations at risk. Fungal infections include disease that varies from superficial to disseminated infections which are often fatal. No fungal disease is reportable in Oman. Many cases are admitted with underlying pathology, and fungal infection is often not documented. The burden of fungal infections in Oman is still unknown. Using disease frequencies from heterogeneous and robust data sources, we provide an estimation of the incidence and prevalence of Oman’s fungal diseases. An estimated 79,520 people in Oman are affected by a serious fungal infection each year, 1.7% of the population, not including fungal skin infections, chronic fungal rhinosinusitis or otitis externa. These figures are dominated by vaginal candidiasis, followed by allergic respiratory disease (fungal asthma). An estimated 244 patients develop invasive aspergillosis and at least 230 candidemia annually (5.4 and 5.0 per 100,000). Only culture and microscopy are currently available for diagnosis, so case detection is suboptimal. Uncertainty surrounds these figures that trigger the need for urgent local epidemiological studies with more sensitive diagnostics.
Anti-Ageing Protein β-Klotho Rejuvenates Diabetic Stem Cells for Improved Gene-Activated Scaffold Based Wound Healing
Authors: Suku Meenakshi , Laiva Ashang Luwang , O’Brien Fergal J. , Keogh Michael B.
Published: December 2020

Skin wounds can lead to serious morbidity complications in diabetic patients due to the reduced healing potential of autologous stem cells. One reason for the low functional potency of stem cells from diabetic patients (diabetic stem cells) is attributed to their senescent-like nature. Here, we investigated if an anti-ageing protein, β-klotho, could be used to rejuvenate diabetic stem cells and to promote pro-angiogenic gene-activated scaffold (GAS)-induced functional response for wound healing applications. Human stem cells derived from the adipose tissue (adipose-derived stem cells (ADSCs)) of normal and diabetic (type 2) donors were used for the study. We report that the β-klotho priming facilitated inflammatory signal pruning by reducing interleukin-8 release by more than half while concurrently doubling the release of monocyte chemoattractant protein-1. Additionally, β-klotho priming enhanced the pro-angiogenic response of diabetic ADSCs on GAS by dampening the release of anti-angiogenic factors (i.e., pigment epithelium-derived factor, tissue inhibitor of metalloproteinase-1 and thrombospondin-1) while simultaneously supporting the expression of pro-angiogenic factors (i.e., Vascular Endothelial Growth Factor (VEGF), angiopoietin-2 and angiogenin). Finally, we show that β-klotho pre-treatment expedites the cellular expression of matrix proteins such as collagen IV and collagen VI, which are implicated in tissue maturation. Taken together, our study provides evidence that the synergistic effect of the pro-angiogenic GAS and β-klotho activation effectively accelerates the functional development of diabetic ADSCs for wound healing applications.
Scoring Osteoarthritis Reliably in Large Joints and the Spine Using Whole-Body CT: OsteoArthritis Computed Tomography-Score (OACT-Score)
Authors: Gielis Willem Paul , Weinans Harrie , Nap Frank J. , Roemer Frank W. , Foppen Wouter
Published: December 2020

A standardized method to assess structural osteoarthritis (OA) burden thorough the body lacks from literature. Such a method can be valuable in developing personalized treatments for OA. We developed a reliable scoring system to evaluate OA in large joints and the spine—the OsteoArthritis Computed Tomography (OACT) score, using a convenience sample of 197 whole-body low-dose non-contrast CTs. An atlas, containing example images as reference points for training and scoring, are presented. Each joint was graded between 0–3. The total OA burden was calculated by summing scores of individual joints. Intra- and inter-observer reliability was tested 25 randomly selected scans (N = 600 joints). Intra-observer reliability and inter-observer reliability between three observers was assessed using intraclass correlation coefficient (ICC) and square-weighted kappa statistics. The square-weighted kappa for intra-observer reliability for OACT-score at joint-level ranged from 0.79 to 0.95; the ICC for the total OA grade was 0.97 (95%-CI, 0.94 to 0.99). Square-weighted kappa for interobserver reliability ranged from 0.48 to 0.95; the ICC for the total OA grade was 0.95 (95%-CI, 0.90 to 0.98). The OACT score, a new reproducible CT-based grading system reflecting OA burden in large joints and the spine, has a satisfactory reproducibility. The atlas can be used for research purposes, training, educational purposes and systemic grading of OA on CT-scans.