bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Functional Depletion of Doublesex on Male Development in the Sawfly, Athalia rosae
Authors: Mine Shotaro , Sumitani Megumi , Aoki Fugaku , Hatakeyama Masatsugu , Suzuki Masataka G.
Published: September 2021

The doublesex (dsx) gene, which encodes a transcription factor, regulates sexual differentiation in insects. Sex-specific splicing of dsx occurs to yield male- and female-specific isoforms, which promote male and female development, respectively. Thus, functional disruption of dsx leads to an intersexual phenotype in both sexes. We previously identified a dsx ortholog in the sawfly, Athalia rosae. Similar to dsx in other insects, dsx in the sawfly yields different isoforms in males and females as a result of alternative splicing. The sawfly exploits a haplodiploid mode of reproduction, in which fertilized eggs develop into diploid females, whereas unfertilized eggs parthenogenetically develop into haploid males. In the present study, we knocked down the A. rosae ortholog of dsx (Ardsx) during several developmental stages with repeated double-stranded RNA (dsRNA) injections. Knockdown of Ardsx via parental RNA interference (RNAi), which enables knockdown of genes in offspring embryos, led to a lack of internal and external genitalia in haploid male progeny. Additional injection of dsRNA targeting Ardsx in these animals caused almost complete male-to-female sex reversal, but the resulting eggs were infertile. Notably, the same knockdown approach using diploid males obtained by sib-crossing caused complete male-to-female sex reversal; they were morphologically and behaviorally females. The same RNAi treatment did not affect female differentiation. These results indicate that dsx in the sawfly is essential for male development and its depletion caused complete male-to-female sex reversal. This is the first demonstration of functional depletion of dsx not causing intersexuality but inducing total sex reversal in males instead.
The Incidence of Wolbachia Bacterial Endosymbiont in Bisexual and Parthenogenetic Populations of the Psyllid Genus Cacopsylla (Hemiptera, Psylloidea)
Authors: Shapoval Nazar A. , Nokkala Seppo , Nokkala Christina , Kuftina Galina N. , Kuznetsova Valentina G.
Published: September 2021

Wolbachia is one of the most common intracellular bacteria; it infects a wide variety of insects, other arthropods, and some nematodes. Wolbachia is ordinarily transmitted vertically from mother to offspring and can manipulate physiology and reproduction of their hosts in different ways, e.g., induce feminization, male killing, and parthenogenesis. Despite the great interest in Wolbachia, many aspects of its biology remain unclear and its incidence across many insect orders, including Hemiptera, is still poorly understood. In this report, we present data on Wolbachia infection in five jumping plant-lice species (Hemiptera, Psylloidea) of the genus Cacopsylla Ossiannilsson, 1970 with different reproductive strategies and test the hypothesis that Wolbachia mediates parthenogenetic and bisexual patterns observed in some Cacopsylla species. We show that the five species studied are infected with a single Wolbachia strain, belonging to the supergroup B. This strain has also been found in different insect orders (Lepidoptera, Hemiptera, Plecoptera, Orthoptera, Hymenoptera, Diptera) and even in acariform mites (Trombidiformes), suggesting extensive horizontal transmission of Wolbachia between representatives of these taxa. Our survey did not reveal significant differences in infection frequency between parthenogenetic and bisexual populations or between males and females within bisexual populations. However, infection rate varied notably in different Cacopsylla species or within distinct populations of the same species. Overall, we demonstrate that Wolbachia infects a high proportion of Cacopsylla individuals and populations, suggesting the essential role of this bacterium in their biology.
Vaccination for Respiratory Infections in Patients with Heart Failure
Authors: Girerd Nicolas , Chapet Nicolas , Roubille Camille , Roncalli Jérôme , Salvat Muriel , Mouquet Frédéric , Lamblin Nicolas , Gueffet Jean-Pierre , Damy Thibaud , Galinier Michel , Tartiere Jean-Michel , Janssen Cécile , Berthelot Emmanuelle , Aguilhon Sylvain , Escamilla Roger , Roubille François
Published: September 2021

Bronchopulmonary infections are a major trigger of cardiac decompensation and are frequently associated with hospitalizations in patients with heart failure (HF). Adverse cardiac effects associated with respiratory infections, more specifically Streptococcus pneumoniae and influenza infections, are the consequence of inflammatory processes and thrombotic events. For both influenza and pneumococcal vaccinations, large multicenter randomized clinical trials are needed to evaluate their efficacy in preventing cardiovascular events, especially in HF patients. No study to date has evaluated the protective effect of the COVID-19 vaccine in patients with HF. Different guidelines recommend annual influenza vaccination for patients with established cardiovascular disease and also recommend pneumococcal vaccination in patients with HF. The Heart Failure group of the French Society of Cardiology recently strongly recommended vaccination against COVID-19 in HF patients. Nevertheless, the implementation of vaccination recommendations against respiratory infections in HF patients remains suboptimal. This suggests that a national health policy is needed to improve vaccination coverage, involving not only the general practitioner, but also other health providers, such as cardiologists, nurses, and pharmacists. This review first summarizes the pathophysiology of the interrelationships between inflammation, infection, and HF. Then, we describe the current clinical knowledge concerning the protective effect of vaccines against respiratory diseases (influenza, pneumococcal infection, and COVID-19) in patients with HF and finally we propose how vaccination coverage could be improved in these patients.
Comparison of Therapeutic Effects of Topical Calcineurin Inhibitor and Moisturizing Cream on Pruritic External Auditory Canal
Authors: Lee Sang-Yeon , Cho Soyun , Kim Minju , Lee Dong-Han , Kim Young Ho
Published: September 2021

Although pruritic external auditory canal (PEAC) is a relatively common symptom, particularly in the geriatric population, its pathophysiology and appropriate treatment remain to be elucidated. We compared the therapeutic efficacy of pimecrolimus, a topical calcineurin inhibitor (CI), and a moisturizing cream (MC) in patients with PEAC. Thirty-nine patients (73 ears) were prospectively enrolled and treated topically twice daily with the CI (n = 20, 39 ears) or the MC (n = 19, 34 ears) for two weeks. The change in itching sensation was evaluated subjectively using a self-questionnaire at immediately, one month, and two months after self-application, and objectively by changes in erythema grading. Although topical treatment with the CI resulted in a more rapid improvement than treatment with the MC in patients with PEAC, the final outcomes did not differ between the groups. Furthermore, similar improvements in erythema scores were noted. The results of this study suggest that the MC, which rejuvenates the normal physiological status of the ear canal skin, may greatly benefit those elderly patients more susceptible to PEAC, without any concerns about adverse events and underlying comorbidities. Expanding upon the understanding of the role of moisturizers in the treatment of pruritic ears merits attention, as this knowledge provides a good example of the clinical guidelines for the management of PEAC.
Clinical Characteristics and Predictors of All-Cause Mortality in Patients with Hypertensive Urgency at an Emergency Department
Authors: Shin Jeong-Hun , Kim Byung Sik , Lyu Minhyung , Kim Hyun-Jin , Lee Jun Hyeok , Park Jin-kyu , Lim Young-Hyo , Shin Jinho
Published: September 2021

Hypertensive urgency is characterized by an acute increase in blood pressure without acute target organ damage, which is considered to be managed with close outpatient follow-up. However, limited data are available on the prognosis of these cases in emergency departments. We investigated the characteristics and predictors of all-cause mortality in Korean emergency patients with hypertensive urgency. This cross-sectional study included patients aged ≥18 years who visited an emergency tertiary referral center between January 2016 and December 2019 for hypertensive urgency, which was defined as a systolic blood pressure of ≥180 mmHg and a diastolic blood pressure of ≥110 mmHg, or both, without acute target organ damage. The 1 and 3 year all-cause mortality rates were 6.8% and 12.1%, respectively. The incidence of emergency department revisits and readmission after 3 months and 1 year was significantly higher in non-survivors than in survivors. In a multivariate analysis, age ≥ 60 years (hazard ratio (HR), 16.66; 95% CI, 6.20–44.80; p < 0.001), male sex (HR, 1.54; 95% CI, 1.22–1.94; p < 0.001), history of chronic kidney disease (HR, 2.18; 95% CI, 1.53–3.09; p < 0.001), and proteinuria (HR, 1.94; 95% CI, 1.53–2.48; p < 0.001) were independent predictors of 3 year all-cause mortality. The all-cause mortality rate of hypertensive urgency remains high despite the increased utilization of antihypertensive medications. Old age, male sex, history of chronic kidney disease, and proteinuria were poor prognostic factors for all-cause mortality in patients with hypertensive urgency.
Management of Liver Tumors during the COVID-19 Pandemic: The Added Value of Selective Internal Radiation Therapy (SIRT)
Authors: Bargellini Irene , Boni Giuseppe , Traino Antonio Claudio , Bozzi Elena , Lorenzoni Giulia , Bianchi Francesca , Cervelli Rosa , Depalo Tommaso , Crocetti Laura , Volterrani Duccio , Cioni Roberto
Published: September 2021

Background: In the context of the coronavirus disease 2019 (COVID-19) pandemic, liver-directed therapies (LDTs) may offer minimally invasive integrative tools for tumor control. Among them, selective internal radiation therapy (SIRT) represents a safe, flexible and effective treatment. Purpose of this study is to present our experience with SIRT during the first wave of COVID-19 pandemic and provide an overview of the indications and challenges of SIRT in this scenario. Methods: We retrospectively analyzed the number of patients evaluated by Multidisciplinary Liver Tumor Board (MLTB) and who were undergoing LDTs between March and July 2020 and compared it with 2019. For patients treated with SIRT, clinical data, treatment details and the best radiological response were collected. Results: Compared to 2019, we observed a 27.5% reduction in the number of patients referred to MLTB and a 28.3% decrease in percutaneous ablations; transarterial chemoembolizations were stable, while SIRT increased by 64%. The majority of SIRT patients (75%) had primary tumors, mostly HCC. The best objective response and disease control rates were 56.7% and 72.2%, respectively. Conclusion: The first wave of the COVID-19 pandemic was characterized by an increased demand for SIRT, which represents a safe, flexible and effective treatment, whose manageability will further improve by simplifying the treatment workflow, developing user-friendly and reliable tools for personalized dosimetry and improving interdisciplinary communication.
Igg Food Antibody Guided Elimination-Rotation Diet Was More Effective than FODMAP Diet and Control Diet in the Treatment of Women with Mixed IBS—Results from an Open Label Study
Authors: Ostrowska Lucyna , Wasiluk Diana , Lieners Camille F. J. , Gałęcka Mirosława , Bartnicka Anna , Tveiten Dag
Published: September 2021

Irritable bowel syndrome (IBS) is a chronic disease with recurrent abdominal pain, disturbed bowel emptying, and changes in stool consistency. We compared the effectiveness of three different dietary treatment plans (G1-FM-low FODMAP diet, G2-IP IgG based elimination-rotation-diet, and as control group, the G3-K control diet recommended by an attending gastroenterologist) in treating patients diagnosed with mixed irritable bowel syndrome. A total of seventy-three female patients diagnosed with a mixed form of irritable bowel syndrome (IBS-M) were enrolled in the study. The diet of each patient in Group 1 (G1-FM) and 2 (G2-IP) was determined individually during a meeting with a dietitian. Patients from Group 3 (G3-K) received nutrition advice from a gastroenterologist. Significant differences in the reduction of IBS symptoms were found between the groups. IBS symptoms as well as comorbid symptoms significantly improved or disappeared completely in the G2-IP group (idiopathic abdominal pain, p < 0.001; abdominal pain after a meal, p < 0.001; abdominal pain during defecation, p = 0.008), while in the G1-FM group, some of the IBS symptoms significantly improved (mucus in stool, p = 0.031; bloating, p < 0.001). In group G3-K no significant improvement was seen. Based on the results of this open-label study, it was concluded that various dietary interventions in the treatment of IBS-M patients do not uniformly affect the course and outcomes of disease management. Rotation diets based on IgG show significantly better results compared to other diets.
Sexual Behaviour and Fantasies in a Group of Young Italian Cohort
Authors: Di Mauro Marina , Russo Giorgio Ivan , Polloni Gaia , Tonioni Camilla , Giunti Daniel , Cito Gianmartin , Giammusso Bruno , Morelli Girolamo , Masieri Lorenzo , Cocci Andrea
Published: September 2021

Over the years, sexual behaviour has changed due to the growing interest in everything related to the sexual sphere. The purpose of the study was to collect information on the sexual habits and behaviours of Italian people of all ages, sexes and sexual orientations and to describe the patterns of sexual behaviour, with the aim of gaining a representative picture of sexuality in Italy, before the COVID-19 pandemic. Participants completed a survey with 99 questions about their sexual habits. In our group first sexual experiences occurred on average around the age of 15, whilst the median age of the first sexual intercourse was 17. The fantasies that most stimulated and excited our group (Likert scale ≥ 3) was having sex in public (63.9%), having sex with more than one person at the same time (59.4%), blindfolded sex (64.9%), being tied up (56.3%) and observing a naked person (48.6%). As for pornography, we have shown that 80% of our group watched porn at home, alone or from their smartphones. Our results have several practical implications for the areas of sex education and sexual health. It is necessary to safeguard the health of young people and support them increasing their sexual well-being.
Quantitative Craniofacial Analysis and Generation of Human Induced Pluripotent Stem Cells for Muenke Syndrome: A Case Report
Authors: Kidwai Fahad K. , Mui Byron W. H. , Almpani Konstantinia , Jani Priyam , Keyvanfar Cyrus , Iqbal Kulsum , Paravastu Sriram S. , Arora Deepika , Orzechowski Pamela , Merling Randall K. , Mallon Barbara , Myneni Vamsee D. , Ahmad Moaz , Kruszka Paul , Muenke Maximilian , Woodcock Jeremiah , Gilman Jeffrey W. , Robey Pamela G. , Lee Janice S.
Published: September 2021

In this case report, we focus on Muenke syndrome (MS), a disease caused by the p.Pro250Arg variant in fibroblast growth factor receptor 3 (FGFR3) and characterized by uni- or bilateral coronal suture synostosis, macrocephaly without craniosynostosis, dysmorphic craniofacial features, and dental malocclusion. The clinical findings of MS are further complicated by variable expression of phenotypic traits and incomplete penetrance. As such, unraveling the mechanisms behind MS will require a comprehensive and systematic way of phenotyping patients to precisely identify the impact of the mutation variant on craniofacial development. To establish this framework, we quantitatively delineated the craniofacial phenotype of an individual with MS and compared this to his unaffected parents using three-dimensional cephalometric analysis of cone beam computed tomography scans and geometric morphometric analysis, in addition to an extensive clinical evaluation. Secondly, given the utility of human induced pluripotent stem cells (hiPSCs) as a patient-specific investigative tool, we also generated the first hiPSCs derived from a family trio, the proband and his unaffected parents as controls, with detailed characterization of all cell lines. This report provides a starting point for evaluating the mechanistic underpinning of the craniofacial development in MS with the goal of linking specific clinical manifestations to molecular insights gained from hiPSC-based disease modeling.
Variability in Anthropogenic Underwater Noise Due to Bathymetry and Sound Speed Characteristics
Authors: Vagle Svein , Burnham Rianna E. , O’Neill Caitlin , Yurk Harald
Published: September 2021

Oceanic acoustic environments are dynamic, shaped by the spatiotemporal variability in transmission losses and sound propagation pathways of natural and human-derived noise sources. Here we used recordings of an experimental noise source combined with transmission loss modeling to investigate changes in the received levels of vessel noise over space and time as a result of natural water column variability. Recordings were made in the Juan de Fuca Strait, on the west coast of Vancouver Island, a biologically productive coastal region that hosts several cetacean species. Significant variability in noise levels was observed due to changing water masses, tied to seasonal temperature variation and, on a finer scale, tidal movements. Comparisons of interpreted received noise levels through the water column indicated that vessel noise recorded by bottom-stationed monitoring devices might not accurately represent those received by whales in near-surface waters. Vertical and temporal differences of 3–5 dB were commonly observed in both the recorded and modeled data. This has implications in estimating the success of noise mitigation measures, and our understanding of the change in sound fields experienced by target species for conservation.
Native Advertising—The Formats and Types of Content Most Demanded by Brands in the Spanish Media
Authors: Zomeño Daniel , Blay-Arráez Rocío
Published: September 2021

Media convergence and the incorporation of new narratives typical of the consumption habits of younger audiences in the social media environment have led to the proliferation of a wide variety of formats and types of content in the media ecosystem through which the editorial content offered to brands is being distributed. This qualitative research, using in-depth interviews with a qualified sample of branded content managers from the main Spanish media, allows us to determine the main characteristics of the native advertising demanded by advertisers. The results corroborate observations that content channelled through more sophisticated consumption experiences, using both multimedia and interactivity with a clear transmedia approach, tends to be better received by the audience and, therefore, in greater demand by brands. It also confirms that both video and social media formats have grown exponentially when it comes to providing an outlet for branded content. Based on the results obtained, a proposed classification of these products, including definitions, has been drawn up so they can be publicised to the professional world, offering the reflection and precision that their rapid development has not allowed until now.
The Impact of the COVID-19 Pandemic on Nursing Care: A Cross-Sectional Survey-Based Study
Authors: Clari Marco , Luciani Michela , Conti Alessio , Sciannameo Veronica , Berchialla Paola , Di Giulio Paola , Campagna Sara , Dimonte Valerio
Published: September 2021

The COVID-19 pandemic has had a severe impact on nursing care. This cross-sectional survey-based study compared aspects of nursing care and nurses’ satisfaction with care provided before and during the first wave of the COVID-19 pandemic. A total of 936 registered nurses (RNs) rated the frequency with which they performed fundamental care, nursing techniques, patient education, symptom management, and nurse–patient relationships before and during the pandemic. A recursive partitioning for ordered multivariate response in a conditional inference framework approach was applied. More frequent fundamental cares were associated with their frequency before the pandemic (p < 0.001), caring for COVID-19 patients (p < 0.001), and workplace reassignment (p = 0.004). Caring for COVID-19 patients (p < 0.001), workplace reassignment (p = 0.030), and caring for ≤7.4 COVID-19 patients (p = 0.014) increased nursing techniques. RNs in high-intensity COVID-19 units (p = 0.002) who educated patients before the pandemic, stopped this task. RNs caring for COVID-19 patients reported increased symptom management (p < 0.001), as did RNs caring for more non-COVID-19 patients (p = 0.037). Less frequent nurse–patient relationships before the pandemic and working in high-intensity COVID-19 units decreased nurse–patient relationships (p = 0.002). Despite enormous challenges, nurses continued to provide a high level of care. Ensuring the appropriate deployment and education of nurses is crucial to personalize care and to maintain nurses’ satisfaction with the care provided.
Mapping the Medieval Wall System of China and Mongolia: A Multi-Method Approach
Authors: Storozum Michael , Golan Dan , Wachtel Ido , Zhang Zhidong , Lotze Johannes S. , Shelach-Lavi Gideon
Published: September 2021

The Medieval Wall System of China and Mongolia is one of the longest wall systems in the world, but its specific chronology, function, and purpose remain ambiguous. Constructed at various points throughout the 10th to 13th centuries CE, this network of walls, forts, and enclosures covers an estimated 4000 km and spans a wide range of ecozones, from the deserts of western China to the steppes of northern Mongolia and the Khingan mountain range. In this article we used historical atlases, topographic maps, and an array of different kinds of data derived from satellite remote sensing, to produce one of the first accurate maps of the Medieval Wall System. Through this large-scale mapping program, we are now able to evaluate previous work that estimates the length of the wall system and different areas of construction. By measuring the structures associated with the wall and the length of the wall itself, we identified at least three different areas of construction along the Medieval Wall System. Future studies may be able to use similar tools to develop more accurate maps of other wall systems throughout Eurasia to further advance the comparative study of ancient wall systems.
Mechanism of Microwave Activation on Molybdenite
Authors: Yang Shuangping , Zhang Tiantian , Liu Shouman , Sun Haixing
Published: September 2021

The effect of microwave activation on the properties of oxidation roasting for molybdenite was investigated under the protection of inert gas, and the specific surface area, the oxidation properties, lattice constant, microstructure, and shape of molybdenite were analyzed and characterized by a laser particle size analyzer, thermogravimetry (TG), X-ray diffractometry (XRD) and scanning electron microscopy (SEM). The results show that microwave activation could effectively reduce the residual amount of sulfur in the molybdenum calcine and decrease the average particle size of molybdenite while increasing the specific surface area of molybdenite. On increasing the microwave activation power, the crystal cell volume and grain size of MoS2 reduced, and the microstrain increased slightly. At the same time, the surface shape of molybdenite became looser, but the layered structure is not changed. In addition, the oxidation property changed significantly; microwave activation promoted the oxidation reaction of molybdenite above 538 °C, and the rate of weight loss increased from 6.177% to 7.718% at 620 °C.
S. aureus and K. pneumoniae on the Surface and within Core of Tonsils in Adults with Recurrent Tonsillitis
Authors: Klagisa Renata , Kroica Juta , Kise Ligija
Published: September 2021

Background and Objectives: Recurrent tonsillitis is an infection of the palatine tonsils. Samples for microbiological testing are usually obtained from the inflamed surface of the tonsils. Colonizing the surface bacteria does not always correlate with pathogens causing recurrent tonsillitis and there is no consensus or this in research studies. The aim of the study was to compare whether Staphylococcus aureus (S. aureus) and Klebsiella pneumoniae (K. pneumoniae) differ when isolated from the tonsillar surface or tonsillar crypts in patients with recurrent tonsillitis. Materials and Methods: a case series study was conducted at a tertiary referral center among 25 patients diagnosed with recurrent tonsillitis. An evaluation of S. aureus and K. pneumoniae incidence, biofilm formation and antibacterial susceptibility was performed. Results: There was a statistically significant association between surface and punch biopsy samples for S. aureus (Fisher’s Exact test p = 0.004) and K. pneumoniae (Fisher’s Exact test p < 0.001). A McNemar test did not reveal a statistically significant association. Although the antibacterial resistance profile was not broad, five out of nine S. aureus isolates were biofilm producers and four out of five K. pneumoniae isolates were biofilm producers. Conclusions: Surface and core cultures of tonsils are comparable with a differing incidence between the surface and the punch biopsy cultures for S. aureus and K. pneumoniae. A larger quantity of bacteria exist in surface samples suggesting that a biopsy sample may be less challenging in evaluating recurrent tonsillitis. We recommend that antibacterial susceptibility results are considered alongside the biofilm-forming potential of isolated bacteria.
Research on the Mathematical Model of Local Equilibrium in the Top-Blown Smelting Process of Electronic Waste
Authors: Wen Xiaochun , Wang Jinliang , Wang Houqing
Published: September 2021

In the present study, the local equilibrium modeling and division method of the multiphase non-equilibrium for the top-blowing smelting process of electronic waste was investigated based on the local equilibrium hypothesis. And the mathematical description of the multi-phase equilibrium of each local area and the correlation method between the local areas were studied by analysis of relationships among the valence state, phase, composition, and Gibbs free energy of each element. Afterward, the reaction characteristic data such as melting material, product phase, composition, temperature, atmosphere, etc. were obtained via industrial measurement experiments. Based on these, a mathematical model of local equilibrium for the top-blowing smelting process of electronic waste was established. Finally, the thermodynamic digital simulation system was developed via the calculation of metallurgical process and online control platform MetCal Desk (v7.00, MetCal, Ganzhou, China), which can investigate the element distribution behavior during the smelting process and provide theoretical guidance for the industrial production practice.
Identification of α-Glucosidase Inhibitors from Leaf Extract of Pepper (Capsicum spp.) through Metabolomic Analysis
Authors: Assefa Samuel Tilahun , Yang Eun-Young , Asamenew Gelila , Kim Heon-Woong , Cho Myeong-Cheoul , Lee Jundae
Published: September 2021

Metabolomics and in vitro α-glucosidase inhibitory (AGI) activities of pepper leaves were used to identify bioactive compounds and select genotypes for the management of type 2 diabetes mellitus (T2DM). Targeted metabolite analysis using UPLC-DAD-QToF-MS was employed and identified compounds that belong to flavone and hydroxycinnamic acid derivatives from extracts of pepper leaves. A total of 21 metabolites were detected from 155 samples and identified based on MS fragmentations, retention time, UV absorbance, and previous reports. Apigenin-O-(malonyl) hexoside, luteolin-O-(malonyl) hexoside, and chrysoeriol-O-(malonyl) hexoside were identified for the first time from pepper leaves. Pepper genotypes showed a huge variation in their inhibitory activity against α-glucosidase enzyme(AGE) ranging from 17% to 79%. Genotype GP38 with inhibitory activity of 79% was found to be more potent than the positive control acarbose (70.8%.). Orthogonal partial least square (OPLS) analyses were conducted for the prediction of the AGI activities of pepper leaves based on their metabolite composition. Compounds that contributed the most to the bioactivity prediction model (VIP >1.5), showed a strong inhibitory potency. Caffeoyl-putrescine was found to show a stronger inhibitory potency (IC50 = 145 µM) compared to acarbose (IC50 = 197 µM). The chemometric procedure combined with high-throughput AGI screening was effective in selecting polyphenols of pepper leaf for T2DM management.
Acute L-Citrulline Supplementation Increases Nitric Oxide Bioavailability but Not Inspiratory Muscle Oxygenation and Respiratory Performance
Authors: Theodorou Anastasios A. , Zinelis Panagiotis T. , Malliou Vassiliki J. , Chatzinikolaou Panagiotis N. , Margaritelis Nikos V. , Mandalidis Dimitris , Geladas Nickos D. , Paschalis Vassilis
Published: September 2021

The present study aimed to investigate whether acute L-citrulline supplementation would affect inspiratory muscle oxygenation and respiratory performance. Twelve healthy males received 6 g of L-citrulline or placebo in a double-blind crossover design. Pulmonary function (i.e., forced expired volume in 1 s, forced vital capacity and their ratio), maximal inspiratory pressure (MIP), fractional exhaled nitric oxide (NO•), and sternocleidomastoid muscle oxygenation were measured at baseline, one hour post supplementation, and after an incremental resistive breathing protocol to task failure of the respiratory muscles. The resistive breathing task consisted of 30 inspirations at 70% and 80% of MIP followed by continuous inspirations at 90% of MIP until task failure. Sternocleidomastoid muscle oxygenation was assessed using near-infrared spectroscopy. One-hour post-L-citrulline supplementation, exhaled NO• was significantly increased (19.2%; p < 0.05), and this increase was preserved until the end of the resistive breathing (16.4%; p < 0.05). In contrast, no difference was observed in the placebo condition. Pulmonary function and MIP were not affected by the L-citrulline supplementation. During resistive breathing, sternocleidomastoid muscle oxygenation was significantly reduced, with no difference noted between the two supplementation conditions. In conclusion, a single ingestion of 6 g L-citrulline increased NO• bioavailability but not the respiratory performance and inspiratory muscle oxygenation.
Co-Infections by Fusarium circinatum and Phytophthora spp. on Pinus radiata: Complex Phenotypic and Molecular Interactions
Authors: Aloi Francesco , Zamora-Ballesteros Cristina , Martín-García Jorge , Diez Julio J. , Cacciola Santa Olga
Published: September 2021

This study investigated the complex phenotypic and genetic response of Monterey pine (Pinus radiata) seedlings to co-infections by F. circinatum, the causal agent of pine pitch canker disease, and the oomycetes Phytophthora xcambivora and P. parvispora. Monterey pine seedlings were wound-inoculated with each single pathogen and with the combinations F. circinatum/P. xcambivora and F. circinatum/P. parvispora. Initially, seedlings inoculated only with F. circinatum showed less severe symptoms than seedlings co-inoculated or inoculated only with P. xcambivora or P. parvispora. However, 30 days post-inoculation (dpi), all inoculated seedlings, including those inoculated only with F. circinatum, showed severe symptoms with no significant differences among treatments. The transcriptomic profiles of three genes encoding pathogenesis-related proteins, i.e., chitinase (PR3), thaumatin-like protein (PR5), phenylalanine ammonia-lyase (PAL), and the pyruvate decarboxylase (PDC)-encoding gene were analyzed at various time intervals after inoculation. In seedlings inoculated with single pathogens, F. circinatum stimulated the up-regulation of all genes, while between the two oomycetes, only P. xcambivora induced significant up-regulations. In seedlings co-inoculated with F. circinatum and P.xcambivora or P. parvispora none of the genes showed a significant over-expression 4 dpi. In contrast, at 11 dpi, significant up-regulation was observed for PR5 in the combination F. circinatum/P.xcambivora and PDC in the combination F. circinatum/P. parvispora, thus suggesting a possible synergism of multiple infections in triggering this plant defense mechanism.
Experimental and Numerical Study on the Compressive Failure of Composite Laminates with Fiber Waviness Defects
Authors: Wang Yuequan , Zhu Shuhua , Li Hongshuang , Zhou Long , Yi Wentao
Published: September 2021

Fiber waviness defects are found in the inner surface of the hat-shaped stringers manufactured by a process system. In order to establish the acceptance criterion for the stringers with the fiber waviness defects, experimental testing and numerical simulation were carried out in this study. Specially induced fiber waviness defects of four pre-defined severity levels were manufactured and tested. A maximum of a 58.1% drop in compressive failure load is observed for the most severe level in the experimental results. A finite element model with progressive damage method and cohesive zone technique was developed to simulate the failure process and the impact of fiber waviness defects. The numerical simulation results of compressive failure load have a good agreement with experimental results qualitatively and quantitatively. In addition, two simple parameters, i.e., aspect ratio A/H and the number of plies with fiber waviness, are proposed to characterize the influence of the fiber waviness on the compressive failure load for the purpose of fast engineering quality checks.
Polymethyl Methacrylate Quality Modeling with Missing Data Using Subspace Based Model Identification
Authors: Patel Nikesh , Sivanathan Kavitha , Mhaskar Prashant
Published: September 2021

This paper addresses the problem of quality modeling in polymethyl methacrylate (PMMA) production. The key challenge is handling the large amounts of missing quality measurements in each batch due to the time and cost sensitive nature of the measurements. To this end, a missing data subspace algorithm that adapts nonlinear iterative partial least squares (NIPALS) algorithms from both partial least squares (PLS) and principal component analysis (PCA) is utilized to build a data driven dynamic model. The use of NIPALS algorithms allows for the correlation structure of the input–output data to minimize the impact of the large amounts of missing quality measurements. These techniques are utilized in a simulated case study to successfully model the PMMA process in particular, and demonstrate the efficacy of the algorithm to handle the quality prediction problem in general.
Air Pollution Analysis during the Lockdown on the City of Milan
Authors: Lotrecchiano Nicoletta , Trucillo Paolo , Barletta Diego , Poletto Massimo , Sofia Daniele
Published: September 2021

From February 2020, the progressive adoption of measures to contain coronavirus’s contagion has resulted in a sudden change in anthropogenic activities in Italy, especially in Lombardy. From a scientific point of view, this situation represents a unique laboratory for understanding and predicting the consequences of specific measures aimed at improving air quality. In this work, the lockdown effect on Milan’s (Italy) air quality was analyzed. The PM10 and PM2.5 values were measured by the ARPA Lombardia, and the real-time on-road (ROM) air quality monitoring network indicates the seasonality of these pollutants, which typically record the highest values in the coldest months of the year. The 10-year particulate matter concentrations analysis shows a PM10 reduction of 35% from 2010 to 2020. March 2020 data analysis shows an alternation of days with higher and lower particulate matter concentrations; values decrease in pollutants concentrations of 16%, respective to 2018. The complexity of the phenomena related to the atmospheric particulates formation, transport, and accumulation is highlighted by some circumstances, such as the Sahara dust events. The study showed that the trend of a general pollutant concentration reduction should be attributed to the decrease in emissions (specifically, from the transport sector) from the variation of meteorological and environmental conditions.
A Cotton High-Efficiency Water-Fertilizer Control System Using Wireless Sensor Network for Precision Agriculture
Authors: Du Chanchan , Zhang Lixin , Ma Xiao , Lou Xiaokang , Shan Yongchao , Li He , Zhou Runmeng
Published: September 2021

Scientific researchers have applied newly developed technologies, such as sensors and actuators, to different fields, including environmental monitoring, traffic management, and precision agriculture. Using agricultural technology to assist crop fertilization is an important research innovation that can not only reduce the workload of farmers, but also reduce resource waste and soil pollution. This paper describes the design and development of a water-fertilizer control system based on the soil conductivity threshold. The system uses a low-cost wireless sensor network as a data collection and transmission tool and transmits the data to the decision support system. The decision support system considers the change in soil electrical conductivity (EC) and moisture content to guide the application of water-fertilizer, and then improves the fertilization accuracy of the water-fertilizer control system. In the experiment, the proposed water-fertilizer control system was tested, and it was concluded that, compared with the existing traditional water-fertilizer integration control system, the amount of fertilizer used by the system was reduced by 10.89% on average, and it could save 0.76–0.87 tons of fertilizer throughout the whole growth period of cotton.
On Restoring the Centrality of Prudentia (Phronēsis) for Living Well: Pathways and Contemporary Relevance
Authors: Ryan Fáinche
Published: September 2021

The aftermath of the Second World War saw some radical rethinking in both theology and philosophy on what it is to live well as a human being. In philosophy two of the key thinkers were Elizabeth Anscombe and Philippa Foot. In theology two key thinkers were Thomas Deman, a French Dominican, and somewhat later an English Dominican, Herbert McCabe. A key feature in all four thinkers was a recovery of the work of Aristotle and Aquinas, in particular the concept of phronēsis (prudentia). The paper’s close analysis of the virtue of prudentia demonstrates the insufficiency of modern moral philosophies that are committed to portraying morality as a moral code. A correlative argument is made within theology: the virtue of prudentia fortified by the gift of counsel is central for good Christian living.
Fine-Scale Urban Heat Patterns in New York City Measured by ASTER Satellite—The Role of Complex Spatial Structures
Authors: Nath Bibhash , Ni-Meister Wenge , Özdoğan Mutlu
Published: September 2021

Urban areas have very complex spatial structures. These spatial structures are primarily composed of a complex network of built environments, which evolve rapidly as the cities expand to meet the growing population’s demand and economic development. Therefore, studying the impact of spatial structures on urban heat patterns is extremely important for sustainable urban planning and growth. We investigated the relationship between surface temperature obtained by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER, at 90 m spatial resolution) and different urban components based on high-resolution QuickBird satellite imagery classification. We further investigated the relationships between ASTER-derived surface temperature and building footprint and land use information acquired by the New York City (NYC) Department of City Planning. The ASTER image reveals fine-scale urban heat patterns in the NYC metropolitan region. The impervious-medium and dark surfaces, along with bright covers, generate higher surface temperatures. Even with highly reflective urban surfaces, the presence of impervious materials leads to an increased surface temperature. At the same time, trees and shadows cast by buildings effectively reduce urban heat; on the contrary, grassland does not reduce or amplify urban heat. The data aggregated to the census tract reveals high-temperature hotspots in Queens, Brooklyn, and the Bronx region of NYC. These clusters are associated with industrial and manufacturing areas and multi-family walk-up buildings as dominant land use. The census tracts with more trees and higher building height variability showed cooling effects, consistent with shadows cast by high-rise buildings and trees. The results of this study can be valuable for urban heat island modeling on the impact of shadow generated by building heights variability and trees on small-scale surface temperature patterns since recent image reveals similar hotspot locations. This study further helps identify the risk areas to protect public health.
Fast and High-Quality 3-D Terahertz Super-Resolution Imaging Using Lightweight SR-CNN
Authors: Fan Lei , Zeng Yang , Yang Qi , Wang Hongqiang , Deng Bin
Published: September 2021

High-quality three-dimensional (3-D) radar imaging is one of the challenging problems in radar imaging enhancement. The existing sparsity regularizations are limited to the heavy computational burden and time-consuming iteration operation. Compared with the conventional sparsity regularizations, the super-resolution (SR) imaging methods based on convolution neural network (CNN) can promote imaging time and achieve more accuracy. However, they are confined to 2-D space and model training under small dataset is not competently considered. To solve these problem, a fast and high-quality 3-D terahertz radar imaging method based on lightweight super-resolution CNN (SR-CNN) is proposed in this paper. First, an original 3-D radar echo model is presented and the expected SR model is derived by the given imaging geometry. Second, the SR imaging method based on lightweight SR-CNN is proposed to improve the image quality and speed up the imaging time. Furthermore, the resolution characteristics among spectrum estimation, sparsity regularization and SR-CNN are analyzed by the point spread function (PSF). Finally, electromagnetic computation simulations are carried out to validate the effectiveness of the proposed method in terms of image quality. The robustness against noise and the stability under small are demonstrate by ablation experiments.
Automatic Reconstruction of Building Façade Model from Photogrammetric Mesh Model
Authors: Zhang Yunsheng , Zhang Chi , Chen Siyang , Chen Xueye
Published: September 2021

Three-dimensional (3D) building façade model reconstruction is of great significance in urban applications and real-world visualization. This paper presents a newly developed method for automatically generating a 3D regular building façade model from the photogrammetric mesh model. To this end, the contour is tracked on irregular triangulation, and then the local contour tree method based on the topological relationship is employed to represent the topological structure of the photogrammetric mesh model. Subsequently, the segmented contour groups are found by analyzing the topological relationship of the contours, and the original mesh model is divided into various components from bottom to top through the iteration process. After that, each component is iteratively and robustly abstracted into cuboids. Finally, the parameters of each cuboid are adjusted to be close to the original mesh model, and a lightweight polygonal mesh model is taken from the adjusted cuboid. Typical buildings and a whole scene of photogrammetric mesh models are exploited to assess the proposed method quantitatively and qualitatively. The obtained results reveal that the proposed method can derive a regular façade model from a photogrammetric mesh model with a certain accuracy.
The Detection of Thread Roll’s Margin Based on Computer Vision
Authors: Shi Zhiwei , Shi Weimin , Wang Junru
Published: September 2021

The automatic detection of the thread roll’s margin is one of the kernel problems in the textile field. As the traditional detection method based on the thread’s tension has the disadvantages of high cost and low reliability, this paper proposes a technology that installs a camera on a mobile robot and uses computer vision to detect the thread roll‘s margin. Before starting, we define a thread roll‘s margin as follows: The difference between the thread roll‘s radius and the bobbin’s radius. Firstly, we capture images of the thread roll‘s end surface. Secondly, we obtain the bobbin’s image coordinates by calculating the image’s convolutions with a Circle Gradient Operator. Thirdly, we fit the thread roll and bobbin’s contours into ellipses, and then delete false detections according to the bobbin’s image coordinates. Finally, we restore every sub-image of the thread roll by a perspective transformation method, and establish the conversion relationship between the actual size and pixel size. The difference value of the two concentric circles’ radii is the thread roll’s margin. However, there are false detections and these errors may be more than 19.4 mm when the margin is small. In order to improve the precision and delete false detections, we use deep learning to detect thread roll and bobbin’s radii and then can calculate the thread roll’s margin. After that, we fuse the two results. However, the deep learning method also has some false detections. As such, in order to eliminate the false detections completely, we estimate the thread roll‘s margin according to thread consumption speed. Lastly, we use a Kalman Filter to fuse the measured value and estimated value; the average error is less than 5.7 mm.
The Role of Tapered Light-Diffusing Fibers in Plasmonic Sensor Configurations
Authors: Cennamo Nunzio , Arcadio Francesco , Zeni Luigi , Catalano Ester , Del Prete Domenico , Buonanno Gionatan , Minardo Aldo
Published: September 2021

In this work, we experimentally analyzed the effect of tapering in light-diffusing optical fibers (LDFs) when employed as surface plasmon resonance (SPR)-based sensors. Although tapering is commonly adopted to enhance the performance of plasmonic optical fiber sensors, we have demonstrated that in the case of plasmonic sensors based on LDFs, the tapering produces a significant worsening of the bulk sensitivity (roughly 60% in the worst case), against a slight decrease in the full width at half maximum (FWHM) of the SPR spectra. Furthermore, we have demonstrated that these aspects become more pronounced when the taper ratio increases. Secondly, we have established that a possible alternative exists in using the tapered LDF as a modal filter after the sensible region. In such a case, we have determined that a good trade-off between the loss in sensitivity and the FWHM decrease could be reached.