bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between red cell distribution width and mortality in patients undergoing continuous ambulatory peritoneal dialysis
Authors: Hsieh Yao-Peng , Tsai Shr-Mei , Chang Chia-Chu , Kor Chew-Teng , Lin Chi-Chen
Published: April 2017

Although red cell distribution width (RDW) has emerged as a biomarker of clinical prognostic value across a variety of clinical settings in the last two decades, limited evidence is available for its role in end-stage renal disease. We enrolled 313 incident patients undergoing continuous ambulatory peritoneal dialysis (CAPD) in this retrospective observational study from 2006 to 2015. In the fully adjusted model of Cox regression analysis, the adjusted hazard ratios for the high RDW group versus the low RDW group were 2.58 (95% confidence interval (CI) = 1.31–5.09, p = 0.006) and 3.48 (95% CI = 1.44–8.34, p = 0.006) for all-cause and cardiovascular disease (CVD)-related mortality, respectively. Based on area under the receiver operating characteristic curve (AUC) analysis, RDW (AUC = 0.699) had a stronger predictive value for all-cause and CVD-related mortality than other biological markers including hemoglobin (AUC = 0.51), ferritin (AUC = 0.584), iron saturation (AUC = 0.535), albumin (AUC = 0.683) and white blood cell count (AUC = 0.588). Given that RDW is a readily available hematological parameter without the need for additional cost, we suggest that it can be used as a valuable index to stratify the risk of mortality beyond a diagnosis of anemia.
Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue
Authors: Nakane Takeichiro , Masumoto Hidetoshi , Tinney Joseph P. , Yuan Fangping , Kowalski William J. , Ye Fei , LeBlanc Amanda J. , Sakata Ryuzo , Yamashita Jun K. , Keller Bradley B.
Published: April 2017

The current study describes a scalable, porous large-format engineered cardiac tissue (LF-ECT) composed of human induced pluripotent stem cells (hiPSCs) derived multiple lineage cardiac cells with varied 3D geometries and cell densities developed towards the goal of scale-up for large animal pre-clinical studies. We explored multiple 15 × 15 mm ECT geometries using molds with rectangular internal staggered posts (mesh, ME), without posts (plain sheet, PS), or long parallel posts (multiple linear bundles, ML) and a gel matrix containing hiPSC-derived cardiomyocytes, endothelial, and vascular mural cells matured in vitro for 14 days. ME-ECTs displayed the lowest dead cell ratio (p < 0.001) and matured into 0.5 mm diameter myofiber bundles with greater 3D cell alignment and higher active stress than PS-ECTs. Increased initial ECT cell number beyond 6 M per construct resulted in reduced cell survival and lower active stress. The 6M-ME-ECTs implanted onto 1 week post-infarct immune tolerant rat hearts engrafted, displayed evidence for host vascular coupling, and recovered myocardial structure and function with reduced scar area. We generated a larger (30 × 30 mm) ME-ECT to confirm scalability. Thus, large-format ECTs generated from hiPSC-derived cardiac cells may be feasible for large animal preclinical cardiac regeneration paradigms.
Flexible transparent displays based on core/shell upconversion nanophosphor-incorporated polymer waveguides
Authors: Park Bong Je , Hong A-Ra , Park Suntak , Kyung Ki-Uk , Lee Kwangyeol , Seong Jang Ho
Published: April 2017

Core/shell (C/S)-structured upconversion nanophosphor (UCNP)-incorporated polymer waveguide-based flexible transparent displays are demonstrated. Bright green- and blue-emitting Li(Gd,Y)F4:Yb,Er and Li(Gd,Y)F4:Yb,Tm UCNPs are synthesized via solution chemical route. Their upconversion luminescence (UCL) intensities are enhanced by the formation of C/S structure with LiYF4 shell. The Li(Gd,Y)F4:Yb,Er/LiYF4 and Li(Gd,Y)F4:Yb,Tm/LiYF4 C/S UCNPs exhibit 3.3 and 2.0 times higher UCL intensities than core counterparts, respectively. In addition, NaGdF4:Yb,Tm/NaGdF4:Eu C/S UCNPs are synthesized and they show red emission via energy transfer and migration of Yb3+ → Tm3+ → Gd3+ → Eu3+. The C/S UCNPs are incorporated into bisphenol A ethoxylate diacrylate which is used as a core material of polymer waveguides. The fabricated stripe-type polymer waveguides are highly flexible and transparent (transmittance > 90% in spectral range of 443–900 nm). The polymer waveguides exhibit bright blue, green, and red luminescence, depending on the incorporated UCNPs into the polymer core, under coupling with a near infrared (NIR) laser. Moreover, patterned polymer waveguide-based display devices are fabricated by reactive ion etching process and they realize bright blue-, green-, and red-colored characters under coupling with an NIR laser.
Polymorphism in the Alternative Donor Site of the Cryptic Exon of LHCGR: Functional Consequences and Associations with Testosterone Level
Authors: Liu Wei , Han Bing , Zhu Wenjiao , Cheng Tong , Fan Mengxia , Wu Jiajun , Yang Ying , Zhu Hui , Si Jiqiang , Lyu Qifeng , Chai Weiran , Zhao Shuangxia , Song Huaidong , Kuang Yanping , Qiao Jie
Published: April 2017

Selective splicing is a feature of luteinizing hormone receptor (LHCGR). A cryptic exon (LHCGR-exon 6A) was found to be derived from alternative splicing in intron 6 of the LHCGR gene, which including two transcripts LHCGR-exon 6A-long and LHCGR-exon 6A-short. We addressed the functional consequences of SNP rs68073206, located at the +5 position of an alternative 5′ splice donor site, and observed its association with male infertility in the subjects with azoospermia, oligoasthenozoospermia and normozoospermia. The translation product of splicing variant LHCGR-exon 6A was expressed in the cytoplasm and exhibited no affinity with [125I]-hCG. No dominant negative effect was observed in cells co-expressed with LHCGR-exon 6A and wild-type LHCGR. The long transcript (LHCGR-exon 6A-long) was significantly elevated in the granulosa cells with G/G genotypes, which could be reproduced in vitro by mini-gene construct transfection. Genotyping analysis showed no association between rs68073206 and male infertility. However, this polymorphism was significantly associated with testosterone levels in normozoospermic subjects (n = 210). In conclusion, SNP rs68073206 in the splicing site of the cryptic exon 6A of the LHCGR gene affect the splicing pattern in the gene, which may play a role in the modulation of the LHCGR sensitivity in the gonads.
Adiabatic Generation of N-quNit Singlet States with Cavity QED
Authors: Yang Rong-Can , Ye Li-Xiang , Lin Xiu , Liu Hong-Yu
Published: April 2017

We present a theoretical scheme to generate N-quNit singlet states with N "Equation missing" 3 via adiabatic passage. In this protocol, the system may be robust against both experimental parameter fluctuations and dissipations along dark states. In addition, during the whole procedure, quantum information is almost fully transferred between atomic ground states. It reduces the influence of dissipations such as atomic spontaneous emissions and cavity decays. Thus, the presented proposal may be feasible based on current technologies.
Decreased Amount of Supporting Alveolar Bone at Single-Rooted Premolars Is Under Estimated by 2D Examinations
Authors: Hong Hsiang-Hsi , Chang Chung-Chieh , Hong Adrienne , Liu Heng-Liang , Wang Yen-Li , Chang Shih-Hao , Yen Tzung-Hai
Published: April 2017

The purpose of this study was to relate the proportions of bone-supported root length of a 2D view into the amount of a 3D bone-attached root surface area (BA-RSA) by using a dental laser scanner examination. White-light 3D scanning technology was used to probe 36 maxillary and 35 mandibular single-rooted premolars. The bone-supported height (BSH) and BA-RSA at designated levels (95–25%) were compared using statistical t tests. The 100% BSH and BA-RSA of the maxillary/mandibular premolars were 12.6 ± 1.60 mm/13.45 ± 1.47 mm (p < 0.05) and 220.78 ± 35.31 mm2/199.51 ± 26.33 mm2 (p < 0.01), respectively. Approximately 79–80%, 59–60%, and 35–36% premolars 2D BSH remained in comparison to 75%, 50%, and 25% 3D BA-RSA preservation, respectively. However, corresponding to a 75%, 50%, and 25% 2D BSH reserve, premolars retained 67–68%, 39–41%, and 15–17% 3D BA-RSA, respectively. When taking 1.0 mm connective tissue attachment into account, 60% 3D BA-RSA and 50% 2D BSH loss were noted at the 5.1–5.4 mm clinical attachment level. Assigning a periodontal prognosis and determining the severity of periodontitis for premolars with alveolar bone loss based on 3D’s or 2D’s measurement is inconsistent.
A G-quadruplex structure at the 5′ end of the H19 coding region regulates H19 transcription
Authors: Fukuhara Mitsuko , Ma Yue , Nagasawa Kazuo , Toyoshima Fumiko
Published: April 2017

The H19 gene, one of the best known imprinted genes, encodes a long non-coding RNA that regulates cell proliferation and differentiation. H19 RNA is widely expressed in embryonic tissues, but its expression is restricted in only a few tissues after birth. However, regulation of H19 gene expression remains poorly understood outside the context of genomic imprinting. Here we identified evolutionarily conserved guanine (G)-rich repeated motifs at the 5′ end of the H19 coding region that are consistent with theoretically deduced G-quadruplex sequences. Circular dichroism spectroscopy and electrophoretic mobility shift assays with G-quadruplex-specific ligands revealed that the G-rich motif, located immediately downstream of the transcription start site (TSS), forms a G-quadruplex structure in vitro. By using a series of mutant forms of H19 harboring deletion or G-to-A substitutions, we found that the H19-G-quadruplex regulates H19 gene expression. We further showed that transcription factors Sp1 and E2F1 were associated with the H19-G-quadruplex to either suppress or promote the H19 transcription, respectively. Moreover, H19 expression during differentiation of mouse embryonic stem cells appears to be regulated by a genomic H19 G-quadruplex. These results demonstrate that the G-quadruplex structure immediately downstream of the TSS functions as a novel regulatory element for H19 gene expression.
The fate of patients with intermittent claudication in the 21st century revisited – results from the CAVASIC Study
Authors: Rantner Barbara , Kollerits Barbara , Pohlhammer Johannes , Stadler Marietta , Lamina Claudia , Peric Slobodan , Klein-Weigel Peter , Mühlthaler Hannes , Fraedrich Gustav , Kronenberg Florian
Published: April 2017

Patients with intermittent claudication carry a high risk for cardiovascular complications. The TransAtlantic Inter-Society Consensus (TASC) Group estimated a five-year overall mortality of 30% for these patients, the majority dying from cardiovascular causes. We investigated whether this evaluation is still applicable in nowadays patients. We therefore prospectively followed 255 male patients with intermittent claudication from the CAVASIC Study during 7 years for overall mortality, vascular morbidity and mortality and local PAD outcomes. Overall mortality reached 16.1% (n = 41). Most patients died from cancer (n = 20). Half of patients (n = 22; 8.6%) died within the first five years. Incident cardiovascular events were observed among 70 patients (27.5%), 54 (21.2%) during the first five years. Vascular mortality was low with 5.1% (n = 13) for the entire and 3.1% for the first five years of follow-up. Prevalent coronary artery disease did not increase the risk to die from all or vascular causes. PAD symptoms remained stable or improved in the majority of patients (67%). In summary, compared to TASC, the proportion of cardiovascular events did not markedly decrease over the last two decades. Vascular mortality, however, was low among our population. This indicates that nowadays patients more often survive cardiovascular events and a major number dies from cancer.
Protection of Human Colon Cells from Shiga Toxin by Plant-based Recombinant Secretory IgA
Authors: Nakanishi Katsuhiro , Morikane Shota , Ichikawa Shiori , Kurohane Kohta , Niwa Yasuo , Akimoto Yoshihiro , Matsubara Sachie , Kawakami Hayato , Kobayashi Hirokazu , Imai Yasuyuki
Published: April 2017

Shiga toxin is a major virulence factor of food-poisoning caused byEscherichia colisuch as O157:H7. Secretory immunoglobulin (Ig) A (SIgA) is supposed to prevent infection of the mucosal surface and is a candidate agent for oral immunotherapy. We previously established a recombinant monoclonal antibody (mAb) consisting of variable regions from a mouse IgG mAb specific for the binding subunit of Shiga toxin 1 (Stx1) and the Fc region of mouse IgA. Here we produced a secretory form of the recombinant IgA (S-hyIgA) with transgenicArabidopsis thalianaplant. All the S-hyIgA cDNAs (heavy, light, J chainandsecretory component) were expressed under the control of a bidirectional promoter of a chlorophylla/b-binding protein ofA. thalianawithout using a viral promoter. The plant-based S-hyIgA exhibited antigen binding, and was modified with plant-specificN-linked sugar chains. The Ig heavy chain and secretory components were observed in an intracellular protein body-like structure of the transgenic leaves on immuno-electron microscopy. An extract of the transgenic leaves neutralized the cytotoxicity of Stx1 toward butyrate-treated Caco-2 cells, a human colon carcinoma cell line. These results will contribute to the development of edible therapeutic antibodies such as those for the treatment of mucosal infection.
Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases
Authors: Sabeti Faran , James Andrew C. , Carle Corinne F. , Essex Rohan W. , Bell Andrew , Maddess Ted
Published: April 2017

Multifocal pupillographic objective perimetry (mfPOP) shows regions of slight hypersensitivity away from retinal regions damaged by diabetes or age-related macular degeneration (AMD). This study examines if such results also appear in multifocal visual evoked potentials (mfVEPs) recorded on the same day in the same patients. The pupil control system receives input from the extra-striate cortex, so we also examined evidence for such input. We recruited subjects with early type 2 diabetes (T2D) with no retinopathy, and patients with unilateral exudative AMD. Population average responses of the diabetes patients, and the normal fellow eyes of AMD patients, showed multiple regions of significant hypersensitivity (p < 0.05) on both mfPOP and mfVEPs. For mfVEPs the occipital electrodes showed fewer hypersensitive regions than the surrounding electrodes. More advanced AMD showed regions of suppression becoming centrally concentrated in the exudative AMD areas. Thus, mfVEP electrodes biased towards extra-striate cortical responses (surround electrodes) appeared to show similar hypersensitive visual field locations to mfPOP in early stage diabetic and AMD damage. Our findings suggest that hypersensitive regions may be a potential biomarker for future development of AMD or non-proliferative diabetic retinopathy, and may be more informative than visual acuity which remains largely undisturbed during early disease.
Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells
Authors: Xin Zhonghao , Pu Lingling , Gao Weina , Wang Yawen , Wei Jingyu , Shi Tala , Yao Zhanxin , Guo Changjiang
Published: April 2017

Riboflavin deficiency is widespread in many regions over the world, especially in underdeveloped countries. In this study, we investigated the effects of riboflavin deficiency on protein expression profiles in HepG2 cells in order to provide molecular information for the abnormalities induced by riboflavin deficiency. HepG2 cells were cultured in media containing different concentrations of riboflavin. Changes of cell viability and apoptosis were assessed. A comparative proteomic analysis was performed using a label-free shotgun method with LC–MS/MS to investigate the global changes of proteomic profiles in response to riboflavin deficiency. Immunoblotting test was used to validate the results of proteomic approach. The cell viability and apoptosis tests showed that riboflavin was vital in maintaining the cytoactivity of HepG2 cells. The label-free proteomic analysis revealed that a total of 37 proteins showing differential expression (±2 fold, p < 0.05) were identified after riboflavin deficiency. Bioinformatics analysis indicated that the riboflavin deficiency caused an up-regulation of Parkinson’s disease pathway, steroid catabolism, endoplasmic reticulum stress and apoptotic process, while the fatty acid metabolism, tricarboxylic citrate cycle, oxidative phosphorylation and iron metabolism were down-regulated. These findings provide a molecular basis for the elucidation of the effects caused by riboflavin deficiency.
Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice
Authors: Yang Chun , Fujita Yuko , Ren Qian , Ma Min , Dong Chao , Hashimoto Kenji
Published: April 2017

Accumulating evidence suggests that abnormalities in the composition of the gut microbiota may play a role in the pathogenesis of depression. Although approximately 30% mice are resilient to chronic social defeat stress (CSDS), the role of gut microbiota in this stress resilience is unknown. In this study, male C57BL/6 mice were exposed to a different CD1 aggressor mouse for 10 min on 10 consecutive days. A social interaction test was applied to distinguish between resilient and susceptible mice. Using 16S rRNA analysis, we examined the composition of gut microbiota in feces from control, resilient, and susceptible mice. The marked appearance of Bifidobacterium was detected in the resilient mice, whereas in the control and susceptible mice, Bifidobacterium were below the detection limit. Oral intake of Bifidobacterium significantly increased the number of resilient mice after CSDS compared with vehicle-treated mice. These findings suggest that Bifidobacterium may confer resilience to CSDS. Therefore, supplementation of Bifidobacterium may prevent the onset of depression from stress in humans. In addition, supplementation of Bifidobacterium may prevent or minimize relapse from remission induced by inflammation and/or stress in depressed patients.
Improving “color rendering” of LED lighting for the growth of lettuce
Authors: Han Tao , Vaganov Vitaliy , Cao Shixiu , Li Qiang , Ling Lili , Cheng Xiaoyao , Peng Lingling , Zhang Congzhi , Yakovlev Alexey N. , Zhong Yang , Tu Mingjing
Published: April 2017

Light plays a vital role on the growth and development of plant. On the base of white light with high color rendering to the benefit of human survival and life, we proposed to improve “color rendering” of LED lighting for accelerating the growth of lettuce. Seven spectral LED lights were adopted to irradiate the lettuces under 150 μmol·m−2·s−1 for a 16 hd−1 photoperiod. The leaf area and number profiles, plant biomass, and photosynthetic rate under the as-prepared LED light treatments were investigated. We let the absorption spectrum of fresh leaf be the emission spectrum of ideal light and then evaluate the “color rendering” of as-prepared LED lights by the Pearson product-moment correlation coefficient and CIE chromaticity coordinates. Under the irradiation of red-yellow-blue light with high correlation coefficient of 0.587, the dry weights and leaf growth rate are 2–3 times as high as the sharp red-blue light. The optimized LED light for lettuce growth can be presumed to be limited to the angle (about 75°) between the vectors passed through the ideal light in the CIE chromaticity coordinates. These findings open up a new idea to assess and find the optimized LED light for plant growth.
Coordination chemistry in the design of heterogeneous photocatalysts
Authors: Gao Chao , Wang Jin , Xu Hangxun , Xiong Yujie
Published: April 2017

This review elucidates the roles of coordination chemistry in the design of heterogeneous photocatalysts, which can engineer catalytically active sites, tune light harvesting and maneuver charge kinetics.
Multi-chamber microfluidic platform for high-precision skin permeation testing
Authors: Alberti M. , Dancik Y. , Sriram G. , Wu B. , Teo Y. L. , Feng Z. , Bigliardi-Qi M. , Wu R. G. , Wang Z. P. , Bigliardi P. L.
Published: April 2017

We validated a novel microfluidic permeation array for high-precision and high-throughput skin penetration and toxicity testing or screening of chemicals.
Micro-patterned titanium coatings with a grid-like structure doped with vancomycin against bacteria and affecting osteogenic differentiation
Authors: Wang Guangchao , Zhang Hao , He Qianyun , Tong Dake , Ding Chen , Liu Peizhao , Zhang Zequan , Xie Youtao , Ji Fang
Published: April 2017

The present study aimed to investigate the effects of micro-patterned titanium coatings doped with vancomycin on antibacterial activity and osteogenic differentiation and to improve the bioactivity of the inert titanium..
The flame retardancy and rheological properties of PA6/MCA modified by DOPO-based chain extender
Authors: Cai Jianan , Wirasaputra Alvianto , Zhu Yaming , Liu Shumei , Zhou Yubin , Zhang Chunhua , Zhao Jianqing
Published: April 2017

Addition of DOPO-based chain extender (DEP) simultaneously enhanced the flame retardancy and mechanical properties of PA6/MCA through chain extension and coaction in flame-retarding.
A controlled selective synthesis of dihydropyrans through tandem reaction of alkynes with diazo compounds
Authors: Min Junxiang , Xu Guangyang , Sun Jiangtao
Published: April 2017

A controlled synthesis of dihydropyrans via sequential reaction of allenoate formation and intramolecular oxo-Michael addition has been achieved.
Understanding gas adsorption in MOF-5/graphene oxide composite materials
Authors: Lin Li-Chiang , Paik Dooam , Kim Jihan
Published: April 2017

Metal–organic framework (MOF) and graphene oxide (GO) composite materials (MOF/GO) have been regarded as promising for separation applications due to their synergistically enhanced adsorption properties.
Effects of spatial topologies and electron Fermi-level gradient on the photocatalytic efficiency of nano-particulate semiconductors
Authors: Liu Baoshun , Zhang Rui
Published: April 2017

The present study used the Monte-Carlo random walking model to comprehensively study the effects of nanoparticle spatial topologies and electron Fermi-level gradients on nanoparticulate photocatalysis.
Electron transfer in silicon-bridged adjacent chromophores: the source for blue-green emission
Authors: Bayda Malgorzata , Angulo Gonzalo , Hug Gordon L. , Ludwiczak Monika , Karolczak Jerzy , Koput Jacek , Dobkowski Jacek , Marciniak Bronislaw
Published: April 2017

Electron transfer between adjacent chromophores (N-isopropylcarbazole and divinylbenzene) through a silylene bridge is the source for blue-green emission.
Energy landscapes for machine learning
Authors: Ballard Andrew J. , Das Ritankar , Martiniani Stefano , Mehta Dhagash , Sagun Levent , Stevenson Jacob D. , Wales David J.
Published: April 2017

The energy landscapes framework developed in molecular science provides new insight in the field of machine learning.
Mechanical and vibrational characterization of amyloid-like HET-s nanosheets based on the skewed plate theory
Authors: Chang Hyun Joon , Lee Myeongsang , Kim Jae In , Yoon Gwonchan , Na Sungsoo
Published: April 2017

Fungal prion protein HET-s forms a skewed amyloid-like sheet structure at a certain pH condition. We investigate the mechanical characteristics of coarse-grained HET-s amyloid-like sheet model using vibrational methods.
The folding mechanism and key metastable state identification of the PrP127–147 monomer studied by molecular dynamics simulations and Markov state model analysis
Authors: Zhou Shuangyan , Wang Qianqian , Wang Yuwei , Yao Xiaojun , Han Wei , Liu Huanxiang
Published: April 2017

MD simulation combined with MSM analysis was employed to investigate the structural dynamics and the folding mechanism of the key fragment 127–147 monomer of prion protein.
Platinum-supporting hollandite-type vanadium–chromium mixed oxides as efficient heterogeneous catalysts for deoxygenation of sulfoxides under atmospheric H2 pressure
Authors: Uematsu Tsubasa , Ogasawara Yoshiyuki , Suzuki Kosuke , Yamaguchi Kazuya , Mizuno Noritaka
Published: April 2017

In the presence of hollandite-based catalysts, various sulfoxides and pyridine N-oxides could be converted into deoxygenated products under atmospheric H2 pressure.
Defining the molecular properties of N-nitrosodimethylamine (NDMA) precursors using computational chemistry
Authors: Bond Tom , Simperler Alexandra , Graham Nigel , Ling Li , Gan Wenhui , Yang Xin , Templeton Michael R.
Published: April 2017

Computational descriptors were used to identify previously unknown NDMA precursors.
Facile and sustainable synthesis of nitrogen-doped polymer and carbon porous spheres
Authors: Maetz Amandine , Delmotte Luc , Moussa Georges , Dentzer Joseph , Knopf Stephan , Ghimbeu Camelia Matei
Published: April 2017

A facile and eco-friendly synthetic pathway for the design of polymer and carbon spheres is developed.
C-reactive protein and interleukin 6 microfluidic immunoassays with on-chip pre-stored reagents and centrifugo-pneumatic liquid control
Authors: Zhao Y. , Czilwik G. , Klein V. , Mitsakakis K. , Zengerle R. , Paust N.
Published: April 2017

A centrifugal microfluidic method with pre-stored reagents for automation of particle based immunoassays controlled by the spinning frequency only.
A facile and one-pot synthesis of fluorescent graphitic carbon nitride quantum dots for bio-imaging applications
Authors: Zhan Yan , Liu Zhiming , Liu Qingqing , Huang Di , Wei Yan , Hu Yinchun , Lian Xiaojie , Hu Chaofan
Published: April 2017

Ultrathin g-C3N4 nanosheets and fluorescent g-C3N4 quantum dots are simultaneously prepared via one-pot ethanol-thermal treatment in the presence of KOH.
An Ir(iii)-catalyzed aryl C–H bond carbenoid functionalization cascade: access to 1,3-dihydroindol-2-ones
Authors: Bai Siyi , Chen Xun , Hu Xinwei , Deng Yuanfu , Jiang Huanfeng , Zeng Wei
Published: April 2017

An Ir(iii)-catalyzed relay aryl C–H bond carbenoid insertion cascade of N-aryl-2-pyridinamines with diazo Meldrum's acid has been developed.
Rifamorpholines A–E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp. Hca4
Authors: Xiao Yong Sheng , Zhang Bo , Zhang Mei , Guo Zhi Kai , Deng Xin Zhao , Shi Jing , Li Wei , Jiao Rui Hua , Tan Ren Xiang , Ge Hui Ming
Published: April 2017

Five unusual rifamycin-type antibiotics with potent antibacterial activity were characterized from locust-associated rare actinobacteria, Amycolatopsis sp. HCa4.
Understanding the chemical state of palladium during the direct NO decomposition – influence of pretreatment environment and reaction temperature
Authors: Reddy Gunugunuri K. , Ling Chen , Peck Torin C. , Jia Hongfei
Published: April 2017

The mechanism of direct NO decomposition is different than three-way catalysis and depends on temperature and pretreatment environment over PdO/SiO2.
Near infrared laser-controlled drug release of thermoresponsive microgel encapsulated with Fe3O4 nanoparticles
Authors: Qi Xiaofang , Xiong Lu , Peng Jing , Tang Dongyan
Published: April 2017

One major issue in thermosensitive drug delivery systems is the remote, repeatable control of temperature in vivo through external stimuli such as light, ultrasound, and magnetic field.
New insights into high temperature hydrothermal synthesis in the preparation of visible-light active, ordered mesoporous SiO2–TiO2 composited photocatalysts
Authors: Wu Qin , Liu Chen , Peng Jinjun , Liu Fujian
Published: April 2017

Carbon doped, visible light active and ordered mesoporous TiO2–SiO2 nanocomposites have been successfully synthesized via one step high temperature (180 °C) hydrothermal technology.
Optical and electrical switching of cholesteric liquid crystals containing azo dye
Authors: Oh Seung-Won , Baek Jong-Min , Kim Sang-Hyeok , Yoon Tae-Hoon
Published: April 2017

We propose an optically and electrically switchable cholesteric liquid crystal (ChLC) cell doped with a push–pull azo dye.
Photoconductivity of CaH2-reduced BaSnO3 thin films
Authors: Zhao C. W. , Luo B. C. , Chen C. L.
Published: April 2017

The underlying origin of the photo-response behavior of CaH2 reduced BaSnO3 thin films with metallic conductivity is analyzed.
Retrieving aromaticity of dithiadiazuliporphyrin by oxidation: illustration by experimental and theoretical investigation
Authors: Sung Young Mo , Sprutta Natasza , Kim Jun Oh , Koo Yun Hee , Latos-Grażyński Lechosław , Kim Dongho
Published: April 2017

The photophysical properties of neutral, monocation radical, and dication of dithiadiazuliporphyrin have been examined with a particular focus on their aromaticity.
Addressing the mid-point of polymer chains for multiple functionalization purposes through sequential thiol–epoxy ‘click’ and esterification reactions
Authors: Gadwal Ikhlas , Eom Taejun , Hwang JiHyeon , Choe Youngson , Bang Joona , Khan Anzar
Published: April 2017

A synthetic strategy is devised for the preparation of mid-chain multifunctional polymers.
Preparation of high performance supercapacitor materials by fast pyrolysis of corn gluten meal waste
Authors: Cheng Bin-Hai , Tian Ke , Zeng Raymond J. , Jiang Hong
Published: April 2017

Fast pyrolysis of biomass wastes which is usually finished in a few seconds for the preparation of porous carbonaceous materials (PCMs) is much faster and more energy-efficient than the conventional hydrothermal carbonization (HTC) method and does not require the use of solvents.
Light- and heat-triggered polyurethane based on dihydroxyl anthracene derivatives for self-healing applications
Authors: Fang Yuanlai , Du Xiaosheng , Du Zongliang , Wang Haibo , Cheng Xu
Published: April 2017

To develop materials with self-healing properties, polyurethane (PU) was modified with anthracene derivatives which endowed the PU films with a self-healing ability.
Engineering the crystallinity of MoS2 monolayers for highly efficient solar hydrogen production
Authors: Hai Xiao , Zhou Wei , Chang Kun , Pang Hong , Liu Huimin , Shi Li , Ichihara Fumihiko , Ye Jinhua
Published: April 2017

This work reports the crystallinity engineering of MoS2 monolayers for efficient solar hydrogen production.
Robust transparent superamphiphobic coatings on non-fabric flat substrates with inorganic adhesive titania bonded silica
Authors: Wen Min , Zhong Jie , Zhao Shuangjie , Bu Tongle , Guo Le , Ku Zhiliang , Peng Yong , Huang Fuzhi , Cheng Yi-Bing , Zhang Qi
Published: April 2017

Robust transparent superamphiphobic films are prepared by spray coating of designed micro-nano silica building blocks. The mechanical enhancement and photocatalytic properties are achieved for the films through effective titania bonding.
The long life-span of a Li-metal anode enabled by a protective layer based on the pyrolyzed N-doped binder network
Authors: Zhang Zhenggang , Peng Zhe , Zheng Jieyun , Wang Susu , Liu Zixuan , Bi Yujing , Chen Yousi , Wu Gang , Li Hong , Cui Ping , Wen Zhaoyin , Wang Deyu
Published: April 2017

We utilize a protective porous structure based on the pyrolyzed PAN binder to stabilize the electrolyte/lithium interface to prolong its working life.
Enhanced electroactive β-phase of the sonication-process-derived PVDF-activated carbon composite film for efficient energy conversion and a battery-free acceleration sensor
Authors: Alluri Nagamalleswara Rao , Chandrasekhar Arunkumar , Jeong Ji Hyun , Kim Sang-Jae
Published: April 2017

Self-poled flexible films prepared using a cost-effective sonication method for achieving efficient energy harvesting and a battery-free acceleration sensor.
Triplet harvesting in luminescent Cu(i) complexes by the thermally activated luminescence transition mechanism: impact of the molecular structure
Authors: Su Z. C. , Zheng C. C. , Cheng G. , Che C.-M. , Xu S. J.
Published: April 2017

Thermally induced transition from ordinary phosphorescence to delayed fluorescence in two kinds of luminescent copper(i) complexes is comprehensively investigated by using variable-temperature time-integrated and time-resolved photoluminescence measurements as well as model analysis.
Tips and Tricks to Improve Clinical and Aesthetic Outcomes in Latissimus Dorsi Flap Breast Reconstruction
Authors: Laporta Rosaria , Sorotos Michail , Longo Benedetto , Santanelli di Pompeo Fabio
Published: April 2017

Background The aim of this study is to present technical strategies to decrease donor-site complications, to optimize breast shaping, and to achieve symmetry in one-stage procedure in latissimus dorsi (LD) flap reconstruction.

Methods Between 2004 and 2014, a retrospective review was performed on LD flap reconstructions. Demographics, reconstructive details, clinical and aesthetic outcomes were collected and analyzed. Patients were divided in historical control group (HCG) and new strategy group (NSG). In HCG, a horizontal/oblique LD skin paddle (SP) was drawn; only LD muscle was harvested for the implant pocket; and a contralateral symmetrization was planned without any algorithm. In NSG, a transverse LD-SP was centered on the middle to lower bra strap area; a double-layer muscle coverage was used to create the implant pocket; and a planning algorithm was developed to achieve symmetry.

Results A total of 418 breast reconstructions were performed on 296 patients. The two groups were homogeneous regarding demographics, mastectomy weight, and implant volume (p > 0.05). No differences were observed in the incidence of a contralateral surgery, mean hospitalization time, and mastectomy skin flap and nipple–areola complex complications (p > 0.05), while surgical revision of the balancing procedure was more common in HCG than NSG (p = 0.001). Overall, donor-site morbidities occurred in 50 cases including 3 (1%) seroma in NSG and 17 (14.1%) in HCG, and 8 (2.7%) wound dehiscence in NSG and 18 (14.5%) in HCG (p = 0.001). Mean number of take backs to the operating room for secondary procedure was statistically significant between the groups in favor of NSG (p = 0.001).

Conclusion Careful preoperative planning and adoption of appropriate reconstructive strategies can improve clinical and aesthetic outcomes in LD flap breast reconstruction at long-term follow-up.

Level of Evidence This is a level III, therapeutic study.
The Effects of Yoga in Patients Suffering from Subjective Tinnitus
Authors: Köksoy Sümbüle , Eti Can , Karataş Meltem , Vayisoglu Yusuf
Published: April 2017

Introduction Tinnitus is a perception of sound in the absence of an external source and it is a distressing issue. Yoga is a system of mind-body practices with the goal of uniting the body, mind and soul. It has been shown to reduce anxiety and stress, as well as improving the quality of life.

Objective The aim of this study is to investigate the effects of yoga in patients suffering from chronic subjective tinnitus.

Methods Twelve subjects previously diagnosed with chronic subjective tinnitus were selected for the study. The patients were asked to attend to yoga classes once a week and to practice yoga at home using a worksheet for 3 months. Each yoga class consisted of body exercises (asana), breathing (pranayama) and meditation (shavasana and yoga nidra). Tinnitus scores before and after the yoga classes were compared using the Wilcoxon test.

Results Among the 12 patients, there were 4 men and 8 women and their mean age was 52.5 years. The median duration of tinnitus among the group was 5.4 years. There were statistically significant differences in the stress (p = 0.01), handicap (p = 0.004) and severity (p = 0.007) questionnaires scores.

Conclusion This study indicated that yoga practices may reduce life stress and symptoms of subjective tinnitus.
Ultrasonographic Evaluation of Uterine Involution in the Early Puerperium
Authors: Kristoschek Juliana Hocevar , Silva Fernanda Campos da , Vellarde Guillermo Coca , Moreira de Sá Renato Augusto
Published: April 2017

Purpose Our aim was to describe the changes observed by ultrasonography in uterine dimensions during the early puerperium among women who experienced an uncomplicated puerperium. Additionally, the influence of parity, mode of delivery, breastfeeding and birth weight on uterine involution was evaluated.

Methods Ninety-one patients underwent an ultrasound examination on days 1 (D1), 2 (D2) and 7 (D7) of the postpartum period. The longitudinal, anteroposterior and transverse uterine diameters were measured, and the uterine volume was calculated by the formula: longitudinal diameter (LD) X anteroposterior diameter (APD) X transverse diameter (TD) X 0.45. The thickness and length of the uterine cavity were also measured.

Results The uterine volume and the LD, APD and TD decreased by 44.8%, 20.9%, 11.8% and 20.0% respectively. The uterine cavity thickness was reduced by 23%, and the length of the cavity was reduced by 27.2% on D7. Uterine involution was correlated inversely with parity when the day of the postpartum period was not taken into account (p = 0.01). However, when the uterine involution was correlated to parity separately, with D1, D2 or D3, no correlations were found. A significant difference occurred at D2, when it was found that the uterus had a smaller volume following cesarean section compared with vaginal delivery (p = 0.04). The high birth weight and breastfeeding were significantly related to uterine involution (p ≤ 0.01 and p = 0.04).

Conclusion The sonographic evaluation of the uterus in the early puerperium should consider birth weight, breastfeeding and parity, as well as the delivery route on D2, to identify abnormalities related to uterine involution.
Correction of a Posttraumatic Orbital Deformity Using Three-Dimensional Modeling, Virtual Surgical Planning with Computer-Assisted Design, and Three-Dimensional Printing of Custom Implants
Authors: Day Kristopher M. , Phillips Paul M. , Sargent Larry A.
Published: April 2017

We describe a case of complex, posttraumatic skull and orbital deformities that were evaluated and treated with advanced computer technology, including virtual surgical planning, three-dimensional (3D) modeling, and printed patient custom implants (PCI) fabricated by 3D printing. A 50-year-old man presented to our craniofacial referral center 1 year after failed reduction of complex left orbital, zygomatic, and frontal bone fractures due to a motorcycle collision. The patient's chief complaint was debilitating diplopia in all fields of gaze. On examination, he had left enophthalmos, left canthal displacement, lower eyelid ectropion, vertical orbital dystopia, and a laterally and inferiorly displaced, comminuted zygoma with orbital rim and frontal bone defects. The normal orbit was mirrored to precisely guide repositioning of the globe, orbital reconstruction, and cranioplasty. Preinjury appearance with normal globe position was restored with complete resolution of diplopia. Modern 3D technology allows the surgeon to better analyze complex orbital deformities and precisely plan surgical correction with the option of printing a PCI. These techniques were successfully applied to resolve a case of debilitating diplopia and aesthetic deficits after facial trauma. Further application of advanced 3D computer technology can potentially improve the results of severe orbital and craniofacial trauma reconstruction.
„StigMa“ – Evaluation eines psychologischen Therapieprogramms zu Stigma-Management
Authors: Schenner Manuela , Kohlbauer Daniela , Meise Ullrich , Haller Christina , Pixner-Huber Martina , Stürz Kristina , Günther Verena
Published: April 2017

Ziel der Studie Evaluation des Therapieprogramms „StigMa“ zum Umgang mit internalisiertem Stigma für psychisch Kranke.

Methode 26 tagesklinische PatientInnen absolvierten das Programm „StigMa“, 20 Personen dienten als Kontrollgruppe. Prä-post-Messungen erfolgten mittels der Internalized Stigma of Mental Illness-Skala (ISMI) 1.

Ergebnisse Trotz sehr guter Bewertungen des Programms durch die Therapiegruppe, ließen sich keine signifikanten Interaktionseffekte nachweisen.

Schlussfolgerungen Unter Berücksichtigung inhaltlicher und methodischer Optimierung soll StigMa erneut evaluiert werden.
„Dass ich das ändern muss, damit ich nicht irgendwann kollabiere …“
Authors: Zimber Andreas , Hentrich Stephan , Meyer-Lindenberg Andreas
Published: April 2017

Ziel Identifizierung von Risiko- und Schutzfaktoren, die für die Entstehung psychischer Beeinträchtigungen von Führungskräften bedeutsam sind.

Methodik 15 Interviews mit psychisch belasteten Führungskräften wurden leitfadenorientiert durchgeführt und inhaltsanalytisch ausgewertet.

Ergebnisse Alle Probanden berichteten Beeinträchtigungen ihres psychischen Wohlbefindens. Deren Verlauf war mit der Risikowahrnehmung, der erlebten Handlungskontrolle, dem Gesundheits- und Erholungsverhalten der Führungskräfte und der Gesundheitskultur im Unternehmen assoziiert.

Schlussfolgerung Führungskräfte und Unternehmen sind stärker für die psychischen Risiken von Führungstätigkeiten zu sensibilisieren.
Erkennungsgüte dreier deutschsprachiger Screeninginstrumente für Depression bei hospitalisierten Patienten mit koronarer Herzerkrankung
Authors: Tschorn Mira , Rieckmann Nina , Arolt Volker , Beer Katja , Haverkamp Wilhelm , Martus Peter , Waltenberger Johannes , Müller-Nordhorn Jacqueline , Ströhle Andreas
Published: April 2017

Ziel Vergleich der Erkennungsgüte von drei Depressions-Screeninginstrumenten bei Patienten mit koronarer Herzerkrankung (KHK).

Methodik 1019 KHK-Patienten erhielten den Patient Health Questionnaire (PHQ-9 und PHQ-2) und die Hospital Anxiety and Depression Scale (HADS-D) sowie ein klinisches Interview (Composite International Diagnostic Interview) als Referenzstandard.

Ergebnisse Bezüglich der Erkennungsgüte waren PHQ-9 und HADS-D dem PHQ-2 überlegen. Optimale Cut-off-Werte waren 7 (PHQ-9 und HADS-D) und 2 (PHQ-2).

Schlussfolgerung PHQ-9 und HADS-D haben eine vergleichbare Diskriminationsfähigkeit für depressive Störungen bei KHK-Patienten.
Zusammenhänge des Stationsklimas mit objektiven Rahmenbedingungen psychiatrischer Stationen
Authors: Schalast Norbert , Sieß Julia
Published: April 2017

Ziel der Studie Prüfung der Zusammenhänge zwischen Rahmenbedingungen, klinischer Aufgabenstellung und dem Stationsklima in der allgemeinen (AP) und der forensischen Psychiatrie (FP).

Methode Einschätzung des Stationsklimas auf 104 Stationen (47 AP, 57 FP) mit dem kurzen Stationsklimabogen EssenCES, Erfassung von Stationsbedingungen und problematischen Vorkommnissen.

Ergebnisse Objektive Merkmale des Settings und Aspekte des Stationsklimas sind deutlich assoziiert.

Schlussfolgerungen Viele, aber nicht alle naheliegenden Annahmen über die Bedeutung objektiver Rahmenbedingungen werden bestätigt.
International multicenter comparative trial of endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for the treatment of malignant gastric outlet obstruction
Authors: Khashab Mouen , Bukhari Majidah , Baron Todd , Nieto Jose , El Zein Mohamad , Chen Yen-I , Chavez Yamile , Ngamruengphong Saowanee , Alawad Ahmad , Kumbhari Vivek , Itoi Takao
Published: April 2017

Background and study aims EUS-guided gastroenterostomy (EUS-GE) is a novel procedure that potentially offers long-lasting luminal patency without the risk of tumor ingrowth/overgrowth. This study compared the clinical success, technical success, adverse events (AEs), length of hospital stay (LOHS) and symptom recurrence in EUS-GE versus SGJ.

Methods This was a multicenter international retrospective comparative study of EUS-GE and SGJ in patients with malignant gastric outlet obstruction (GOO) who underwent either EUS-GE or SGJ. EUS-GE was performed using lumen apposing metal stents.

Results A total of 93 patients with malignant GOO treated with either EUS-GE (n = 30) or SGJ (n = 63) were identified. Peritoneal carcinomatosis was present in 13 (43 %) patients in the EUS-GE group and 7 (11 %) patients in the SGJ group (P < 0.001). Although the technical success rate was significantly higher in the SGJ group as compared to the EUS-GE group (100 % vs. 87 %, P = 0.009), the clinical success rate was not different (90 % vs. 87 %, P = 0.18, OR 0.8, 95 %CI 0.44 – 7.07). The rate of AEs was lower in the EUS-GE group, but the difference was not statistically significant (16 % vs 25 %, P = 0.3). The mean LOHS was similar in the EUS-GE group compared to SGJ (P = 0.35). The rate of recurrent GOO was not different between the two groups (3 % vs. 14 %, P = 0.08). Similarly, the mean time to reintervention was similar (88 days vs. 121 days, P = 0.83).

Conclusions EUS-GE is associated with equivalent efficacy and safety as compared to surgical GJ. This is the first comparative trial between both techniques and suggests EUS-GE as a non-inferior but less invasive alter to surgery.
Utilization trends in inpatient endoscopic retrograde cholangiopancreatography (ERCP): A cross-sectional US experience
Authors: Ahmed Moiz , Kanotra Ritesh , Savani Ghanshyambhai , Kotadiya Fenilkumar , Patel Nileshkumar , Tareen Sarah , Fasullo Matthew , Kesavan Mayurathan , Kahn Ahsan , Nalluri Nikhil , Khan Hafiz , Pau Dhaval , Abergel Jeffrey , Deeb Liliane , Andrawes Sherif , Das Ananya
Published: April 2017

Study aims The goal of our study was to determine the current trends for inpatient utilization for endoscopic retrograde cholangiopancreatography (ERCP) and its economic impact in the United States between 2002 and 2013.

Patients and methods A Nationwide Inpatient Sample from 2002 through 2013 was examined. We identified ERCPs using International Classification of Diseases (ICD-9) codes; Procedure codes 51.10, 51.11, 52.13, 51.14, 51.15, 52.14 and 52.92 for diagnostic and 51.84, 51.86, 52.97 were studied. Rate of inpatient ERCP was calculated. The trends for therapeutic ERCPs were compared to the diagnostic ones. We analyzed patient and hospital characteristics, length of hospital stay, and cost of care after adjusting for weighted samples. We used the Cochran-Armitage test for categorical variables and linear regression for continuous variables.

Results A total of 411,409 ERCPs were performed from 2002 to 2013. The mean age was 59 ± 19 years; 61 % were female and 57 % were white. The total numbers of ERCPS increased by 12 % from 2002 to 2011, which was followed by a 10 % decrease in the number of ERCPs between 2011 and 2013.

There was a significant increase in therapeutic ERCPs by 37 %, and a decrease in diagnostic ERCPs by 57 % from 2002 to 2013. Mean length of stay was 7 days (SE = 0.01) and the mean cost of hospitalization was $20,022 (SE = 41).

Conclusions Our large cross-sectional study shows a significant shift in ERCPs towards therapeutic indications and a decline in its conventional diagnostic utility. Overall there has been a reduction in inpatient ERCPs.