bluuebunny/crossref_metadata_2025 huggingface dataset:
Computer network monitoring systems
Authors:   National University of Bioresources and Nature Management of Ukraine, Kovalenko O.Ye. , Kuzniuk K.V. ,   National University of Bioresources and Nature Management of Ukraine
Published: June 2023

Monitoring tools are an important component of network infrastructure and provide automation of network administration processes. The effectiveness of using a monitoring system is a spe-cific indicator of the computer network quality and it depends on the specified settings and sce-narios of its use. The main characteristics and parameters that should be investigated and taken into account when deploying a computer network monitoring system are network scalability, the anticipation of updating the existing system after the deployment, the required level of net-work monitoring complexity, and service functionality. Network management and monitoring tools should include the following key features: detailed analytics, compatibility, simplified overview mode, notifications, and account and interface settings. Detailed analytics and reports are the foundation of network monitoring. The chosen tool should evaluate network perfor-mance by processing parameters of network speed and latency. Compatibility allows you to in-teract with various components of the IT infrastructure. A wide range of compatibility provides a greater variety of characteristics of elements and greater adaptability of the service to the real conditions of a particular enterprise. Alerts from the monitoring system must be instantaneous and sent whenever a threshold value is exceeded or a device is disabled. Monitoring systems allow you to edit the type and severity level of an alert, as well as create monitoring categories and templates. Accounts are an important aspect, particularly for remote work. The user inter-face is important for organizing the process of working with a computer network monitoring system from the point of view of efficiency. A well-organized interface speeds up the interac-tion of an administrator or an operator with information about the current state of the system. An important characteristic of the interface is the adaptability of display on different types of devices: smartphones, tablets, computers, etc.
А clinical case of endovascular treatment for myocardial infarction combined with ischemic stroke
Authors: Grachev N. I. , Rapovka V. G.
Published: June 2023

The paper presents a clinical case of endovascular treatment for a patient affected by acute myocardial infarction combined with acute ischemic stroke. The study emphasizes a role of early diagnosis of ischemic stroke in timely detection of cerebral embolism in large vessels during the postoperative period. Treatment strategy is analyzed along with the effectiveness of intravascular thrombectomy that significantly reduces mortality and disability of patients with acute cerebrovascular disease.
Review of current pain management in patients with lumbosacral transitional vertebrae
Authors: Skryabin E. G. , Romanenko D. A. , Evstropova Yu. V. , Nazarova A. S.
Published: June 2023

Pain in patients with transitional lumbosacral vertebrae is managed with surgical and non-surgical treatment. The non-surgical treatment involves techniques of traditional oriental medicine, manual therapy, physiotherapeutic procedures, and pharmacological blockade. Surgical interventions include resection of the pseudarthrosis, minimally invasive endoscopic surgery, radiofrequency ablation, and interbody fusion. The paper presents immediate and, in some cases, long-term outcomes, the causes of unsatisfactory outcomes and complications. The relevance of the study stems from the high prevalence of lumbosacral transitional vertebrae in the population, and, moreover, the lack of unified, generally accepted algorithms in choosing individual treatment, based on the history of patients, their age, as well as concomitant dystrophic changes of the superior spinal motion segments.
Perspectives of Teachers and Students on Values Education in Secondary School Religious Culture and Moral Knowledge Course
Authors: ARSLAN Seviye , INCE Murat
Published: June 2023

This research was carried out to evaluate the opinions of teachers and students on the values education taught in the secondary school Religious Culture and Moral Knowledge course. In this study, sequential descriptive pattern, one of the mixed method designs, was used. 315 secondary school students studying at seven different schools in the 2021-2022 academic year in Gerede and Dörtdivan districts of Bolu province participated in the study. Participants consisted of 162 female and 153 male students. In the research conducted, the opinions of 10 Religious Culture and Moral Knowledge (DKAB) teachers employed in the Ministry of National Education (MoNE) were sought. The study utilized the “Human Values Scale,” a tool developed for students, and a semi-structured “Teacher Interview Form” to collect data. The qualitative data was analyzed using descriptive analysis technique. According to the results of the research; it was found that student value levels were above average. It was also found that the students’ value levels indicated significant differences according to gender and grade. According to the teachers’ opinions on value education, they emphasized the importance of being role models in instilling values in students. Additionally, the teachers expressed concerns about the challenges posed by the unconscious use of technology and mass media in value education.
ĐẶC ĐIỂM HÌNH THÁI VÀ TRÌNH TỰ MỘT SỐ GEN PHÂN LOẠI CỦA LAN HÀI CẢNH (Paphiopedilum canhii) THU THẬP TẠI LÀO
Authors: Yến Nguyễn Thị Hải , Phát Đỗ Tiến , Mậu Chu Hoàng
Published: June 2023

Paphiopedilum là một chi nổi bật của nhóm lan Hài, đây là một chi nhỏ nhưng có hệ thống phân loại phức tạp với nhiều quan điểm khác nhau. Paphiopedilum canhii phát hiện năm 2010 và được coi là loài đặc hữu của Việt Nam. Các nghiên cứu về loài Paphiopedilum canhii cho thấy vị trí phân loại rất riêng biệt của chúng. Để phân loại chính xác loài này, người ta đã phải sử dụng nhiều tiêu chí kết hợp. Hiện nay, ngoài phương pháp phân loại truyền thống bằng hình thái, thì phương pháp phân loại bằng chỉ thị phân tử đã phát triển và thể hiện nhiều ưu điểm khi sử dụng cho các nghiên cứu phân loại học. Bài báo này trình bày kết quả phân tích hình thái thực vật của lan Hài Cảnh thu thập tại Lào; đồng thời xác định và phân tích 5 trình tự gen phân loại matK, rbcL, rpoC1, ITS và trnH-psbA. Kết quả phân tích cho thấy, hai chỉ thị ITS và trnH-psbA phù hợp khi nghiên cứu phân loại lan Hài, cây phân loại của chúng phản ánh rõ mối quan hệ họ hàng của các loài trong các tổ, phân chi đúng với hệ thống phân loại bằng hình thái. Ba chỉ thị matK, rbcL, rpoC1 cho kết quả phân nhóm pha trộn giữa các tổ và phân chi.
Los procesos judiciales restitutorios de la posesión como actos que interrumpen civilmente la usucapión. Crítica a la postura dominante en la jurisprudencia
Authors: Villegas Valenzuela José Manuel
Published: June 2023

En el presente artículo, el autor realiza un estudio crítico a la postura dominante en la jurisprudencia nacional, con relación a la usucapión, que sostiene que el inicio de procesos judiciales y el envío de cartas notariales dirigidas al usucapiente son actos que afectan la pacificidad de la posesión. Para dicho propósito, desarrolla un análisis en detalle respecto de algunas propuestas interpretativas que se han planteado sobre el tema. Tras ello, concluye que dichas hipótesis no afectan la pacificidad y que solo los procesos judiciales destinados a ordenar la restitución del bien califican como actos interruptores de la usucapión.
EXOPOLYSACCHARIDES OF LACTIC ACID BACTERIA: THE MANIPULATION OF ENVIRONMENTAL STRESSES TO MODULATE BIOSYNTHESIS FOR INDUSTRIAL APPLICATIONS
Authors: Nguyen Tho Phu , Nguyen Thanh Huu
Published: June 2023

Exopolysaccharides are biopolymers produced by microorganisms in response to adverse environmental conditions. Exopolysaccharides of lactic acid bacteria are applied in many different fields such as food, pharmaceuticals, and medicine. This review discusses the biological functions of the exopolysaccharide derived from lactic acid bacteria and their response to exopolysaccharide synthesis under environmental stresses. Environmental stress can alter the expression of eps genes, resulting in changes in yield and monosaccharide composition of obtained exopolysaccharides. Therefore, the evaluation aims to clarify the feasibility of using environmental stress to modify exopolysaccharide biosynthesis in lactic acid bacteria for various applications.-- PDF Article: https://drive.google.com/file/d/1t1yF709I9pb_vSoyNgCBxSn5d22HBF75/view?usp=sharing
DETERMINING THE ALGAE CELL DENSITY AND TOTAL CAROTENOID CONTENT OF HETEROTROPHIC MARINE MICROALGAE - SCHIZOCHYTRIUM AND THRAUSTOCHYTRIUM ON THE COAST OF TRA VINH PROVINCE, VIETNAM
Authors: Pham Nguyen Thi Binh
Published: June 2023

This study aimed to determine the biomass culture capacity and total carotenoid content of heterotrophic marine microalgae genera, including the genus Schizochytrium and Thraustochytrium on the coast of Tra VinhProvince. Five strains of these genera, DH41.79, CN27, DH10, CN15, and CN47, were cultured for biomass and carotenoid content. The study showed that the cell density of CN47 was highest with different periods under three different dilution levels (10%, 20%, and 30%), with a positive relationship between cell density and dryweight of algae strains (R2 ≈ 1 > 0). Besides, the results indicated that all densities of strain CN47 showed carotenoid content of this strain (7,613 µg/kg) was significantly higher than that of the 04 remainings and previous studies. The research results contribute to the foundation for scientific works on the heterotrophic marine microalgae Thraustochytrids, which have a high potential for applications in biomass production,extraction of high-value nutritional compounds for aquaculture, towards sustainable development through replacing fish oil sourced from natural exploitation in Tra Vinh Province.
-- PDF Article: https://drive.google.com/file/d/1ZH_D26XKUBr_ErhN8TRhp5TWkpuwUkwf/view?usp=sharing
Analysis of blood coagulation abnormality signs among patients with severe combined craniofacial trauma
Authors: Nassar A.N.I. , Madai D.Yu. , Iordanishvili A.K. , Idris M.I.
Published: June 2023

Objective. The aim of this paper is to study the pattern of blood coagulation abnormality signs among patients with severe combined craniofacial trauma and their relationship with the trauma outcomes.
Materials and methods. A comparative analysis was carried out of the signs of trauma-induced coagulopathy (platelet count, international normalized ratio and activated partial thromboplastin time) on the 1st and 3rd days of hospital stay in two groups of patients with severe combined craniofacial trauma. The first group included 21 patients with a favorable outcome, the second — 37 patients with an unfavorable outcome. Also, a comparative analysis was carried out of the unfavorable outcome frequency among patients, depending on the trauma-induced coagulopathy presence on the 1st and 3rd days of hospital stay.
Results. The analysis revealed the presence of statistically significant differences in the mean values of activated partial thromboplastin time on the 1st and 3rd days of hospital stay and of international normalized ratio on the 3rd day of hospital stay among patients with favorable and unfavorable outcomes (p<0.05). Differences in the platelets count on the 1st and 3rd days of hospital stay were not statistically significant (p>0.05). The proportion of patients with signs of trauma-induced coagulopathy on the 1st day was 63.8% (37 patients). On the 3rd day, their proportion increased up to 84.5% (49 patients). The frequency difference of the unfavorable outcomes among patients with signs of trauma-induced coagulopathy and those with blood coagulation signs within the physiological norm on the 1st and 3rd days of hospital stay was not statistically significant.
Conclusion. Trauma-induced coagulopathy often occurs in patients with severe combined craniofacial trauma in its acute period, which must be taken into account when performing surgical interventions and intensive care for the patients. According to the study results, it is not possible to confirm the significant impact of this pathology on the outcomes of severe combined craniofacial trauma.
МЕНЕДЖМЕНТ СОЦІОКУЛЬТУРНОЇ ДІЯЛЬНОСТІ ЯК СКЛАДОВА СИСТЕМИ ДЕРЖАВНОГО УПРАВЛІННЯ
Authors: Любарець Владислава
Published: June 2023

Акцентовано увагу на важливих аспектах трансформаційних перетворень соціокультурного менеджменту у системі державного управління. Констатовано, що формування менеджменту соціокультурної діяльності у мінливому соціокультурному середовищі здійснюється з інноваційним підходом у його багатоманітності на загальних функціях управління. Виявлено, що менеджмент соціокультурної діяльності має ознаки державного управління. Означено головні напрями управління менеджментом соціокультурної діяльності. Проаналізовано стратегічні й тактичні завдання, які вирішують державні структури на кожному з зазначених рівнів управління у соціокультурній сфері: стратегічному, тактичному, місцевому. Висвітлено роль і діяльність Міністерства культури та інформаційної політики України у структурі менеджменту соціокультурної діяльності. Розкрито фактори впливу на стан й перспективність розвитку механізму управління в соціокультурній діяльності.
TENENCIA COMPARTIDA: ¿PROBLEMA O SOLUCIÓN FRENTE AL DESARROLLO DE LOS NIÑOS, NIÑAS Y ADOLESCENTES?
Authors: Bravo Soto Danaye Anyel
Published: June 2023

A partir la importancia de los derechos de los niños, niñas y adolescentes, en el presente artículo académico se busca analizar si la tenencia compartida resultaría el medio más idóneo para el adecuado desarrollo del menor. Partiendo de las variables conceptuales del problema en cuestión, con un tratamiento del derecho comparado y de la misma regulación en nuestro ordenamiento, se buscará la formulación de argumentos con base que contribuyan a determinar si este régimen de tenencia compartida ayuda o afecta al desarrollo del menor, teniendo como piedra angular el interés superior del niño, niña y adolescente.
DISMINUCIÓN DE LA EDAD DEL INIMPUTABLE ESTABLECIDA EN EL ARTÍCULO 20 DEL CÓDIGO PENAL COMO POSIBLE SOLUCIÓN PARA DISMINUIR LA VIOLENCIA EN NUESTRO PAÍS
Authors: Tocto Rincón Lina
Published: June 2023

A raíz del gran incremento delincuencial en nuestro país y de los efectos nocivos que de ella derivan, en el presente artículo académico se busca analizar si la reducción de la edad mínima de imputabilidad penal en nuestro sistema contribuirá o afectará en el incremento de la violencia en nuestro país. Con ese propósito, se partirá de la revisión del aspecto teórico de las principales variables relacionadas con la problemática existente, para luego contrastar con el tratamiento normativo jurídico en el Derecho Comparado. Se tratará de identificar resultados que pudiesen ser aplicados dentro de nuestro ordenamiento jurídico y que sirvan de propuesta para contribuir con la reducción de la violencia, cuyos efectos no solo se reflejan en cifras económicas de pobreza y recesión sino que sus efectos nocivos son de tal magnitud que se extienden al largo plazo, puesto que influyen negativamente en el desarrollo integral de los menores de edad quienes se convertirán en futuros ciudadanos.
DISTRIBUTION OF THE MUSKRAT (ONDATRA ZIBETHICUS L.) AND THE AMERICAN MINK (NEOVISON VISON SCHREBER) IN YAKUTIA (NORTHEASTERN ASIA, RUSSIA)
Authors: ZAKHAROV E. , SMETANIN N. , SIDOROV I. , ZAKHAROVA O. , FILIPPOVA V. , ZAKHAROVA N.
Published: June 2023

This paper discusses the results of the introduction of the muskrat and American mink in Yakutia (Russia). The time course of harvesting of muskrat skins during an eighty-one-year period (1941-2021) is also analyzed. A map of quantitative distribution of muskrats in Yakutia was constructed on the basis of the harvesting data. The work on muskrat introduction was described within the framework of hunting activities of unitary enterprise of Sakhabult Financial Agro-Industrial Concern in 2002-2004, when 975 muskrats were resettled in the republic, including 60 animals brought from Altai Krai. Data on the abundance and occurrence of the American mink in Yakutia are provided, and the modern geographic range of this animal is outlined. Information about the introduction of 337 American minks in 1985-1986 by Ust-Mayskiy State Hunting/Fishery Enterprise in the basins of the rivers Maya and Khamna is given.
The role of dupilumab in diverse allergic pathologies
Authors: Zerecero-Morcksharpea Marquelle , Reyes Altamirano Catherin Lizeth , García Vences Edna Elisa
Published: June 2023

Allergic responses represent a significant health problem due to the ineffectiveness of current treatments, as they attempt to decrease the immune response triggered but are unable to create immune memory that reduces the intensity of such response, so the intensity of the response will always be the same as the first time. An allergic response is characterized by the exacerbated and prolonged release of immunoglobulin E (IgE) that triggers innate immune responses due to the activation of T lymphocytes towards a Th2 phenotype, responsible for the release of interleukins 3 and 4 (IL-3 and IL-4), and the activation of B lymphocytes towards IgE-producing plasma cells. Currently, monoclonal antibodies (mAbs) are used as treatment for various allergic pathologies as they can be used to inhibit the signaling pathways of various interleukins, inactivating the differentiation of T lymphocytes, B lymphocytes, and the production of IgE. One of the most versatile mAbs in the treatment of various allergic responses is Dupilumab, which is designed to inhibit the signaling chain of IL-3 and IL-4, more specifically, it binds to the α receptor of IL-4 and the cytokine-induced receptor complex IL-13. Dupilumab inhibits IL-4 and IL-13 through receptor 1, stopping the release of IgE and proinflammatory cytokines. This treatment can be used to control the inflammatory response caused by allergens. On the other hand, the use of Dupilumab is not patented as the treatment of choice for allergic pathologies. Therefore, in this review, we compile the results of clinical studies of Dupilumab and other mAbs in atopic dermatitis (AD), eosinophilic esophagitis (EoE), chronic rhinosinusitis with nasal polyps (CRSwNP), and asthma, with the aim of determining which of the mAbs has provided better results.
Информационные системы контроля и управления процессов дегидратации плодово-ягодного сырья
Authors: Бакин Игорь Алексеевич , Шилов Сергей Викторович , Мустафина Анна Сабирдзяновна
Published: June 2023

Введение. Производственный процесс выработки конечной продукции пищевой промышленности требует соблюдения регламентированных параметров обработки сырья. Контроль определяющих параметров технологии позволяет обеспечить требования качества и безопасности. Повышение эффективности и конкурентоспособности предприятия достигаются внедрением систем управления производством и цифровыми технологиями. Для снижения доли ручного сбора данных и автоматизированного управления технологическим циклом предложено использовать цифровые системы управления и мониторинга оборудования. Принимая во внимание, что качество переработки плодово-ягодного сырья напрямую связано с операциями термической обработки, необходимо обеспечить контроль и управление процессами на этих этапах.

Цель. Цель исследования - разработка концепции и обеспечение автоматизированной системы управления вакуумной дегидратации плодово-ягодного сырья, с реализацией алгоритмов управления в среде SIMATIC PCS7, с использованием программируемых логических контроллеров Siemens Simatic.

Материалы и методы. Объект исследования – система управления и автоматизации для вакуумной дегидратации плодов и ягод, имеющих твердый каркас и капиллярно-пористую структуру, с начальной влажностью до 90%. В качестве методов исследования и реализации методологии управления информационной системы процессов дегидратации использована среда разработки Simatic WinCC. Исследования проводились на оригинальной конструкции сушильной установки. Определение эффективного коэффициента диффузии влаги и константы скорости сушки реализовывалось численными методами решением модели Аррениуса для неизотермических условий.

Результаты. Результатом анализа стал алгоритм изменения параметров технологического процесса дегидратации. Предложено для ускорения процессов обезвоживания применить пониженное давление в первые периоды сушки и последующий кондуктивный энергоподвод. Определены три цикла управления. Вначале осуществляется кондуктивный нагрев до 60 °С при атмосферном давлении. Далее камера сушилки вакуумируется до давления 0,5 кПа и до 0,2 кПа. Установлена длительность предварительного прогрева для ягодного сырья – до 10 минут, второго цикла сушки – до 15 минут при температуре 35°С. Продолжительность третьего цикла 20 минут, при температуре точки насыщения 22 °С. Сформулированы задачи управления процессами с использованием программируемых логических контроллеров Siemens Simatic. Описаны каналы управления и параметры регулирования для обеспечения сохранности биоактивных компонентов сырья.

Выводы. В среде проектирования Simatic WinCC реализованы модули с функциями: прием и передача значений параметров процесса сушки; визуальный контроль; конфигурирование и настройка параметров; принудительное изменение параметров; просмотр информации о регистрируемых в технологической системе событиях. Разработана система визуализации сушильного процесса. Реализованы операторские интерфейсы на панели управления Simatic HMI.
Использование зерна полбы сорта Греммэ в макаронном производстве
Authors: Осипова Галина Александровна , Хмелева Евгения Викторовна
Published: June 2023

Введение. В настоящее время и в России, и за рубежом полба завоёвывает популярность как диетический продукт здорового питания. Мука из зерна полбы находит широкое применение в производстве хлебобулочных, макаронных, мучных кондитерских изделий, регулярное потребление которых способствует укреплению иммунитета, улучшению работы сердечнососудистой, пищеварительной и репродуктивной систем, снижает риск развития анемии, инфекционных и онкологических заболеваний.

Цель. В работе представлены результаты исследования возможности применения голозерного зерна полбы сорта Греммэ в производстве цельнозерновых макаронных изделий.

Материалы и методы. Объекты исследований: зерно полбы сорта Греммэ урожая 2018 г., выращенное в Орловской области; лабораторные образцы макаронного теста; образцы полуфабрикатов макаронных изделий; лабораторные образцы макаронных изделий; образцы макаронных изделий, выработанных на однокорытном макаронном прессе периодического действия фирмы P. Dominioni. Методы исследований: влажность зерна - по ГОСТ 13586.5-2015; содержание и свойства клейковины – по ГОСТ 54478-2011; содержание белка – по ГОСТ 10846-91, натура – по ГОСТ 10840-2017, масса 1000 зерен – по ГОСТ 10842-89, общая стекловидность – по ГОСТ10987-76, число падения – по ГОСТ 27676-88, содержание крахмала – по ГОСТ 10845-98, начальная температура клейстеризации крахмала, температура максимальной вязкости и вязкость крахмального геля - на приборе Амилотест АТ-97 в режиме 2; предельное напряжение сдвига макаронного теста - на приборе СТ-1М; варочные свойства макаронных изделий – по ГОСТ 31964-2012.

Результаты. Обоснован способ предварительной подготовки зерна полбы перед его использованием в производстве макаронных изделий. Параметры замачивания: гидромодуль – 1:1, температура воды – 45 °С, продолжительность замачивания – 45 минут.

Выводы. Изучено влияние продолжительности замачивания зерна полбы сорта Греммэ на количество и свойства сырой клейковины и крахмала, реологические показатели макаронного теста и варочные свойства зерновых макаронных изделий. Потери сухих веществ при варке опытных образцов не превысили 6 %, что соответствует требованиям нормативных документов и характеризует изделия, как изделия высокого качества.
Влияние процесса озонирования на качественные показатели зерна озимой пшеницы
Authors: Баскаков Иван Васильевич , Оробинский Владимир Иванович , Гиевский Алексей Михайлович , Чернышов Алексей Викторович , Чернова Ольга Васильевна
Published: June 2023

Введение. Озонирование позволяет провести дезинсекцию зерна, предпосевную обработку семян, дезинфекцию зерноскладов, дезодорацию продукции, санацию повреждённых зерновок. Однако озонирование способствует протеканию ряда химических реакций, которые оказывают влияние на зерно.

Цель. Определение влияния режимов озонной обработки на качественные показатели зерна озимой пшеницы.

Материалы и методы. При получении озоновоздушной смеси использовали регулируемый по концентрации озонатор производства ООО «ОЗОН ПРОМ-ТЕХ», генерация озона в котором происходит благодаря импульсным преобразователям напряжения и частоты из воздуха. Качественные показатели зерна определяли по соответствующим ГОСТам.

Результаты. Установлено, что озонная обработка зернового материала в течение 1 – 4 часов с концентрацией озона в диапазоне 1,24 – 2,62 мг/м3 способствует повышению содержания клейковины в зерне озимой пшеницы с 21% до 23 – 24%. При этом показатель ИДК увеличился с 68 единиц в контрольном варианте до 71…81 единиц в экспериментальных образцах. Содержание белка в зерне повысилось с 9,74% до 10,69 – 15,0% в зависимости от режима озонной обработки. Стекловидность зерна при озонировании в исследуемом диапазоне концентраций колебалась в диапазоне от -5 до 7% относительно контрольного значения равного 58%. Содержание жира в зерне изменялось вокруг контроля в 0,95 – 1,2 раз. Большие экспозиции, как правило, негативно сказывались на качестве зерна.

Выводы. Рациональное время озонирования составило 100 мин при концентрации озона в озоно-воздушной смеси около 1,6 мг/м3. Это позволит увеличить содержание клейковины и белка в зерне на 2%, жира – в 1,2 раза, показатель ИДК возрастёт на 7 единиц, а стекловидность – на 4%. При этом рациональная доза озонной обработки составила 179 мг·мин/м3.

Ключевые слова: озонная обработка, озимая пшеница, качественные показатели зерна, рациональные режимы озонирования.
Молекулярный in silico скрининг и докинг потенциальных ингибиторов активности ферментов растительного сырья
Authors: Иванов Николай Викторович
Published: June 2023

Введение. Липолиз триацилглицеринов под действием собственной ферментативной системы в семенах подсолнечника – это естественный биохимический процесс. Известно, что моно- и диглицериды жирных кислот, образующиеся при липолизе, являются предшественниками пищевых контаминантов - эфиров глицидола и монохлорпропандиола, которые образуются в технологии переработки жиров. В настоящем исследовании проведен анализ гипотезы, в которой предполагается, что некоторые минорные компоненты в составе семян подсолнечника влияют на биохимический процесс распада триацилглицеринов. Методы. В работе использовались моделирование трехмерной структуры липазы по гомологии, филогенетический анализ, множественное выравнивание аминокислотных последовательностей, анализ карт Раманчандрана, молекулярный докинг.Результаты. Наиболее близким к липазе семян подсолнечника по аминокислотной последовательности является панкреатическая липаза собаки (Canis lupus familiaris), кодируемая геном MPL1. Определено, что согласно множественному выравниванию аминокислотных последовательностей активные центры изучаемых липаз подсолнечника ATLIP1, LIPG, MPL1 не входят в консервативные участки, однако активные центры липазы подсолнечника MPL1 наиболее близки к консервативным участкам потенциального шаблона для моделирования. По итогам множественного выравнивания аминокислотных последовательностей и филогенетического анализа было определено, что выбранные шаблоны для построения модели липаз подсолнечника являются близкородственными и могут быть использованы для гомологичного моделирования. Ингибиторы липазной активности микробиального происхождения показали устойчивую корреляционную зависимость со значениями концентрации полумаксимального ингибирования IC50. По результатам молекулярного докинга минорных компонентов масличного сырья показано, что наибольшим сродством к липазе обладают хлорогеновая и неохлорогеновая кислоты и даидзеин.
MCRformer: Morphological Constraint Reticular Transformer for 3D Medical Image Segmentation
Authors: Li Jun , Chen Nan , Zhou Han , Lai Taotao , Dong Heng , Feng Chunhui , Chen Riqing , Yang Changcai , Cai Fanggang , Wei Lifang
Published: June 2023

Medical image segmentation is essential in medical image analysis since it can provide reliable assistance in computer-aided clinical diagnosis, treatment planning, and intervention. Although deep learning algorithms based on CNNs and Transformers have made notable progress in medical image segmentation, it is still challenging owing to the objects with complex structures, low discrimination and differences between individuals. To alleviate these issues, we propose a novel 3D medical image segmentation network based on Transformers and CNNs combining morphological information and reticular mechanism. Firstly, the morphological constraint stream is designed to learn the prior shape information based on the CNN model and make the attention maps focus on target tasks for enhancing the interpretability. Secondly, the Reticular Transformer is utilized to obtain multi-scale information based on the Transformer, which can bind the local texture information and underlying semantic information to further acquire the feature maps with sufficient details and receptive field. The experiments demonstrate that our proposed method outperforms many existing segmentation models in terms of the performance in metrics DSC and HD (80.46% in DSC on the Synapse dataset and 90.83% in DSC on the ACDC dataset). The code will be released at https://github.com/rocklijun/MCRformer.
News Coverage Disparities Between the 2002 Election and January 6th: A Quantitative Look
Authors: Boyer Ryan , Scherer William
Published: June 2023

We modeled the evening news, using LDA topic modeling, between 2020-11-09 and 2021-01-05, using the transcripts of primetime news programs from three of the major cable news networks (CNN, MSNBC, and Fox News).We see no evidence that the right wing or left-wing partisan media directly incited the January 6th riot. However, FoxNews’s repeated claims of voter fraud, illegal vote counting, and general election conspiracy likely contributed to a political environment that allowed conspiracy, hysteria, and extremism to thrive. As the most watched cable news network in America in 2020 with roughly 20 times more hourly viewers than Newsmax, Fox News’ potential cultural impact is extremely large. People’s frame of reference for decision making is typically based in television news, especially for those over 35; therefore, clear differences in news stories presented will result in a very fragmented national perspective and a difficult political debate.
Effects of Reflective Insrtuctional Strategy on Students’ Performance in Cell Physiology Concepts among Senoir Secondary Schools in Zaria
Authors: Yahaya Halima , Bartholomew Ishaya
Published: June 2023

The study investigated Effect of Reflective Instructional Strategy on students’ performance in Cell-Physiology Concepts among Senior Secondary Students in Zaria. Quasi-experimental pretest, post test control group design. The population comprised of one thousand two hundred and twenty five Biology SS11 students from 11 public Senior Secondary Schools in Zaria metropolis. A sample of 137 students from two schools was randomly selected. The study involves two groups- experimental and a control group. The experimental group was taught Cell Physiology using Reflective Instructional Strategy while the control group was exposed to the same concept using Conventional Method. One instrument was used for data collection Namely Cell-Physiology Performance Test. The instrument was duly validated and have reliability coefficient of 0.87, using Pearson Product Moment Correlation statistic. Two research questions and two null hypotheses were formulated and answered using Mean and Standard deviation statistics and Independent Samples t-test at alpha 0.05 level of significance. The major findings reveals a significant difference between mean academic performance scores in favor of the experimental group. Based on the findings, it was recommended among others, that workshops, seminars and conferences should be organised for Biology teachers on the use of Reflective Instructional among secondary schools in Zaria metropolis.
Factors Associated with Nurses Intentịon to Leave During COVID-19 Pandemic: Literature Review
Authors: Alotibi Amal Metab , Alalwan Ferdous Hussain , Alabdallah Zainab Habeeb
Published: June 2023

COVID-19 pandemic caused enormous damage to the economy and financial status of many countries as well as influenced the peoples’ health and wellbeing, also its impact nurses' job satisfaction and their intention to leave their profession as the nurses form the vast majority of health care workers who have been in the frontline in the pandemic fight. This review aims to assess the factors associated with nurses intention to leave during the covid-19 pandemic. This research paper was made by analyzing the findings of previous studies related to nurses' job satisfaction and intention to leave the job during the (COVID-19) pandemic. The review used Whittemore and Knalfl to conduct the review and locate the related paper. This method considers a broad review method because it allowed the researcher to include varied research types. The findings showed three factors that had a significant impact on nurses' intention to leave, which include: a) fear of COVID 19,b) leak of social support, and c) work-related factors. Analyzing the studies on factors associated with nurses' Intention to Leave during the COVID-19 pandemic revealed various interrelated factors on nurses' intention to leave, including fear of COVID 19, leak support, and several work-related factors.
PENGARUH EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizuz) DALAM MENGHAMBAT DEGRANULASI SEL MAST DAN MENCIT PUTIH JANTAN YANG TERSENSITISASI AKTIF
Authors:   Fakultas Kedokteran, Universitas Baiturrahmah, Yesika Relin , Mutiara A. Meiridha
Published: June 2023

Type I hypersensitivity reactions, also known as allergic reactions or anaphylactic reactions. The mechanism of anaphylaxis involves the release of mediators from mediator cells. The degranulation of mast cells and basophils causes an exaggerated immune response and causes the signs and symptoms of anaphylaxis. Red dragon fruit peel contains secondary metabolites such as triterpenoid flavonoids and steroids. This study was an in vitro study of the ethanol extract of red dragon fruit peel (Hylocereus polyrhizuz) on the mast cells of male white mice induced by antigen. Five variations of the concentration used are 25; 50; 100; 200; 400 µg/mL. The percentage of mast cell degranulation by red dragon fruit peel extract at concentrations of 25; 50; 100; 200 dan 400 µg/mL is 75.27; 69.05; 64.04, 56.61; 45.17; dan 27.88%. There Red dragon fruit peel extract had a significant effect in inhibiting mast cell degranulation (p<0.05).
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN GRANUL EFFERVESCENT DARI KOMBINASI EKSTRAK ETANOL 70% BUNGA ROSELLA (Hibiscus sabdariffa L.) DAN BUNGA TELANG (Clitoria ternatea L.)
Authors:   Universitas Borneo Lestari Banjarbaru, Jamaludin Wahyudin Bin , Masytoh Nadia , Susiani Eka Fitri
Published: June 2023

Rosella (Hibiscus sabdariffa L.) and telang flower (Clitoria ternatea L.) contain anthocyanins which have antioxidant, so the researchers combined to use as effervescent granules. This study aims to determine the characteristics, and the antioxidant activity of effervescent granule combination of rosella and telang flower extract. Antioxidant activity testing using DPPH. The antioxidant activity of the combined thick extract was obtained 𝐼𝐶 50 7.5 ppm, after that it was made into an effervescent granule preparation in 4 formulas. The resut show that all formulas had a characteristic taste of almost uniform color, dark turquoise. In all test formulas for water content, the results obtained are 1.68%-2.82%, compressibility index 11.641%-16%, angle of repose 31.2º-34.43º, flow time 6.25-6.83 seconds, dissolving time 208 -257 seconds and pH 6.2-6.6. The results of the antioxidant activity of effervescent granules revealed 𝐼𝐶 50 of 62,628 ppm (strong).
KARATERISTIK ENKAPSULASI LIPOSOM EKSTRAK SUPEROKSIDA DISMUTASE (SOD) Bacillus altitudinis
Authors:   Fakultas Farmasi, Universitas Setia Budi, Nurfitriyawatie Nurfitriyawatie , Indrayati Ana , Maarif R. Rizal ,   Research Center for Pharmaceutical Ingredients and Traditional Medicine, Nation Research and Innovation Agency
Published: June 2023

Photoaging causes the dermis and collagen fibers to decrease which results in skin aging. Genus Bacillus has SOD activity as an anti-photoaging agent that can neutralize ROS (Reactive Oxygen Species) due to exposure to UV-A rays. This study aimed to examine the activity of crude extract and the encapsulation characteristics of liposomes from B. altitudinis. The study began with the isolation of the SOD enzyme, determination of the total protein content of the crude extract of the SOD enzyme and liposome encapsulation, then characterization liposome tes including particle size analysis, sorption efficiency and zeta potential. The results of the crude extract activity test were 85.09% Â± 1.24%. The characteristic test was produced with a size of 112.96 Â± 17.3 ; the adsorption efficiency was 81.1% and the zeta potential was 7.0 Â±5.1 mV. The results showed that the SOD B. altitudinis liposomes were in the nanoparticle range.
OPTIMASI SODIUM LAURIL SULFAT DAN NATRIUM CHLORIDA PADA SABUN CAIR EKSTRAK LIDAH BUAYA: SIMPLEX LATTICE DESIGN
Authors:   Universitas Bali International, Putra I Gusti Ngurah Agung Windra Wartana , Maharianingsih Ni Made ,   Fakultas Ilmu Kesehatan Universitas Bali Internasional, Widowati I Gusti Rai
Published: June 2023

This study aims to determine the concentration of SLS and NaCl which can produce the best formula of aloe vera extract liquid soap (Aloe vera L.). The method used in this study is the Simplex Lattice Design method. Eight formulas were made with different concentrations of SLS and NaCl, then the parameters of viscosity, specific gravity, foam resistance, and pH were determined. The data obtained was tested with one sample t-test to see the difference between the software's design expert predicted results from the optimization method and the results of laboratory tests. From the results of testing the 8th parameter of the formula, the formula that has the closest desire ability value to 1 was chosen as the optimum formula, namely at a concentration of 180 g of SLS and 65 g of NaCl. From this formula, a one sample t test was carried out between the software's predicted value and laboratory parameter values. The significant values ​​obtained for the parameters of viscosity, specific gravity, foam resistance and pH were 0.570; 0.245; 0.882; 0.069. which means there is no difference in parameter values ​​between the software and the laboratory. It can be concluded that the formula with a variation of SLS of 180 g and NaCl of 65 g is the best formula in the formulation of aloe vera extract liquid soap which produces values ​​that meet quality requirements such as viscosity of 3270 Cp, Specific Weight of 1.079 g/ml, foam resistance of 67%, and pH value 6.73.
FORMULASI GEL HAND SANITIZER EKSTRAK DAUN PALIASA (Kleinhovia hospita Linn) DENGAN GELLING AGENT HPMC
Authors:   Jurusan Farmasi, Politeknik Kesehatan Kemenkes Jakarta II, Elisya Yetri , Wardiyah Wardiyah , Junaedi Junaedi , Hamiah Farah
Published: June 2023

Gel hand sanitizer is a novel product formula that can be utilized as a cost-effective and portable replacement for hand washing soap. One of the plants whose leaves can be used as a central component of hand sanitizer gel is the Paliasa plant (Kleinhovia hospita Linn). Staphylococcus and Escherichia coli resist the antimicrobial effects of alkaloids, tannins, and saponins. To create the hand sanitizer gel, three different concentrations of the HPMC gelling ingredient were used: 1%, 2%, and 3%. Variations in the amount of HPMC used in each formulation impact the gel's characteristics, particularly its viscosity, spreadability, and adherence. Following the cycle test, the three formulations' viscosity decreased, but their pH, spreadability, and stickiness increased. There was no significant difference between the stability test on day 0 and day 12 for pH, viscosity, spreadability, and gel adhesion, according to testing utilizing the paired sample T-test. > 0.05.
STUDI IN SILICO SENYAWA AKTIF ASAM JAWA (Tamarindus indica L.) SEBAGAI ANTIDIABETES MELALUI INHIBISI PROTEIN TYROSINE PHOSPHATASE
Authors:   Program Studi Farmasi, Institut Sains Teknologi Nasional, Pamungkas Tri Setyo , Manalu Rosario Trijuliamos ,   Departemen Bioteknologi, Institut Sains dan Teknologi Nasional
Published: June 2023

Tamarind leaves (Tamarindus indica L.) are widely cultivated in tropical countries, including Indonesia. Empirically, tamarind leaves are known to have anti-diabetic properties. In this study, an in-silico method was used to test the active compounds found in tamarind leaves (Tamarindus indica L.) as anti-diabetic agents through docking score analysis. The target protein used was Protein Tyrosine Phosphatase (5JNT) which is related to insulin resistance. Glimepiride and native ligand 5JNT were used as reference ligands, while the active compounds of tamarind leaves (Tamarindus indica L.) were used as the test ligands. There were 12 active compounds tested for drug-like properties based on the Lipinski Rule of Five, and 12 compounds met the criteria which were then tested through molecular docking using the PLANTS software. Based on the docking results, there were four compounds that had potential as anti-diabetic agents, namely linalool anthranilate, hexadecanol, pentadecanol, and benzyl benzoate, with docking scores of -85.889, -84.23032, -83.12325, and -81.54821 respectively. Although the docking scores of these compounds exceeded the score of the native ligand 5JNT, they did not exceed the score of the reference ligand glimepiride.
The profound impact of the COVID-19 pandemic on seafarers’ health and medical care. The experience of maritime tele-medical assistance services during 2020-2021
Authors: Apostolatos Charalampos , Andria Vivian , Licari Julie , Moschou Maria , Fourlemadis Pantelis , Vasilopoulou Maria , Alvertis Ilias
Published: June 2023

Objective: The access of seafarers to health care services ashore and proper medical care by specialist doctors has been established through an extensive legal framework, which dictates that seafarers are entitled to the same quality of medical care as other employees working onshore. However, during the COVID-19 pandemic, international travel and trade were significantly disrupted, and port restrictions and border closures imposed unprecedented barriers to medical referrals of seafarers ashore, resulting in serious consequences for their health and well-being.
Objective: The objective of this study was to present the serious difficulties and complications faced by telemedical assistance services in managing medical cases on board during 2020-2021.
Methods: The study analyzed all cases reported to Med Solutions International, an international telemedical assistance company, during the two years of the pandemic. It specifically focused on delays and denials of medical referrals ashore, which led to most cases being exclusively handled through telemedicine.
Results: The study demonstrated that only a minority of cases had the opportunity to be referred ashore for medical examination, while many cases were repatriated for further investigation and treatment when ashore referrals were denied. The absence of diagnostic testing and treatment ashore posed significant challenges and frequently endangered the lives of seafarers.
Conclusions: The overall medical care of seafarers and their access to healthcare facilities ashore were severely affected by the COVID-19 pandemic. Telemedical assistance services were tasked with the challenging responsibility of replacing shoreside medical care. The detrimental impact on seafarers' health and human rights calls for corrective measures from international institutions.
ANTI-ALCOHOL EDUCATION OF CHILDREN, YOUTH AND ADULTS AS A FACTOR IN THE FORMATION OF HEALTH-SAVING COMPETENCE THROUGH THE PRISM OF THE HISTORICAL EXPERIENCE OF UKRAINE
Authors: Bilavych Halyna V. , Sultanova Natalia V. , Litvinenko Iryna S. , Biławicz Jan V. , Fedchyshyn Nadiya O. , Fedoniuk Larysa Ya. , Savchuk Borys P.
Published: June 2023

The aim: To analyze the leading trends in anti-alcohol education of children, youth and adults in Western Ukraine from the end of the 19th centry till the 1930s and to determine the possibilities of using this historical experience under modern conditions. Materials and methods: A number of scientific methods were used in the research: chronological, historical, specific-search methods that provide selection, analysis of the source base, make it possible to determine general trends, directions, forms, achievements of anti-alcohol education of children, youth and adults in Western Ukraine from the end of the 19th century till the 1930s; extrapolation and actualization i.e. focus on creative understanding, adaptation and use of this historical experience under modern conditions, consideration of anti-alcohol education of children, youth and adults as a factor in the formation of health preservation and in general the Ukrainian gene pool under the modern challenges of the war, which Ukraine faced. Conclusions: Knowledge about a healthy lifestyle became the basis for people’s health-preserving behavior, anti-alcohol education acted as a factor in the formation of the health-preserving competence of an individual, which included relevant knowledge, skills and behavior for creating and cultivating a health-preserving environment. This experience now deserves to be used creatively in the process of forming the health-saving competence of the individual throughout his life.
THE ROLE OF ECOTOURISM IN THE DEVELOPMENT OF PROTECTED NATURAL AREAS
Authors:   Institute of Industrial Management, Economics and Trade of Peter the Great Saint-Petersburg Polytechnic University,, Putintseva N.A. , Drozdova A.D. ,   Institute of Industrial Management, Economics and Trade of Peter the Great Saint-Petersburg Polytechnic University,, Petrova V.V. ,   Institute of Industrial Management, Economics and Trade of Peter the Great Saint-Petersburg Polytechnic University,
Published: June 2023

The article considers the experience of eco-tourism development in European countries. The basic principles of ecotourism are high-lighted. The types of protected natural terri-tories are identified and the degree of severi-ty of the prohibition of the applicability of forms of use of natural territories is deter-mined. The analysis of the current state of ecotourism development is also carried out on the example of the Russian subjects of the Kaliningrad and Leningrad regions. The study of scientific works allowed us to de-termine the role of ecological tourism in the development of protected natural areas. The development of ecological tourism in special-ly protected natural areas contributes to the formation of people's understanding of the importance of natural areas for the conser-vation of biological diversity.