bluuebunny/crossref_metadata_2025 huggingface dataset:
Ten Years of Cone-Beam CT Airway Studies on Their Relationship with Different Anteroposterior Skeletal Patterns: A Systematic Review
Authors: Saccucci Matteo , Fioravanti Miriam , Pasqualini Aurora , Vozza Iole , Luzzi Valeria , Ierardo Gaetano , Cattaneo Paolo Maria , Polimeni Antonella , Di Carlo Gabriele
Published: January 2025

Objectives: Given the widespread adoption of CBCT in clinical and research activity, it seems reasonable to critically evaluate the evidence produced on the investigations over the relationship between upper airway morphology and skeletal malocclusions patterns. Methods: The analysis method and inclusion criteria were pre-specified and documented in a protocol to minimize the risk of post hoc selective bias. A methodological quality grading system was used to identify the most valuable studies. Results: The nine selected articles, published between 2009 and 2020, involved subjects recruited from existing databases. The average methodological quality grading assessment score was 18.6 (range: minimum 16, maximum 23). Methodological quality scores ranged from 36.1% to 63.8% of the maximum possible score, with an average quality score of 51.1%. No high-quality studies were found in the sample. Conclusions: This systematic review revealed that no high-quality studies have compared upper airway morphology with skeletal patterns using cone-beam computed tomography. The heterogeneity of the results did not confirm strong evidence of a direct correlation between skeletal patterns and upper airway morphology. This appears to be due to a lack of consistency in CBCT protocols.
Iatrogenic Hallux Varus in a Patient with Rheumatoid Arthritis
Authors: Ortiz-Romero Mercedes , Fernandez-Garzon Alvaro , Pabon-Carrasco Manuel , Castro-Mendez Aurora , Gordillo-Fernandez Luis M.
Published: January 2025

Background/Objectives: Iatrogenic hallux varus is a rare complication often arising after hallux valgus surgery, characterized by medial deviation of the hallux. This report presents the case of a 58-year-old female with iatrogenic hallux varus complicated by rheumatoid arthritis (RA). The objective is to highlight the challenges and outcomes of surgical treatment in RA patients with complex foot deformities. Methods: The patient presented with severe medial deviation of the hallux and claw positioning of the lesser toes, resulting in pain and functional limitations. Radiological analysis indicated overcorrection of the first intermetatarsal angle and deformity of the lesser toes. Surgical management included arthrodesis of the first metatarsophalangeal (MTP) joint using K-wires and resection arthroplasty of the lesser metatarsals. Results: Postoperative outcomes revealed correct alignment, pain reduction, and restoration of functional capabilities. However, a non-union was observed in the first MTP arthrodesis after 24 months, which remained asymptomatic. Conclusions: This case underscores the importance of careful surgical planning in RA patients to balance joint preservation and deformity correction. Arthrodesis proved effective for stability and pain relief in RA-associated deformities, although long-term follow-up remains critical to address complications. Tailored interventions are necessary to improve the quality of life in RA patients with complex foot deformities.
Disclosure of Sustainability Information Under the Corporate Social Responsibility Directive: The Degree of Compliance of Portuguese Stock Index Companies
Authors: Azevedo Graça , Oliveira Jonas , Sousa Ivone , Borges Maria Fátima , Tavares Maria C. , Vale José
Published: January 2025

Europe has just published a new Directive on Corporate Sustainability Reporting disclosure and is elaborating new European Sustainability Reporting Standards. To analyze whether companies are complying with the new disclosure requirements before the Corporate Sustainability Reporting Directive (CRSD) on sustainability comes into force, a content analysis was carried out on the corporate reports of 12 companies in the Portuguese Stock Index of Euronext Lisbon for the year 2022, complemented by the score analysis technique. From the study of general disclosures (European Sustainability Reporting Standards—ESRS 2), we concluded that although some companies already comply with various requirements of this standard, they are not disclosing all the information required by ESRS 2 on sustainability. We also concluded, by analyzing the companies’ reports for 2022, that the requirements of the CSRD have different levels of disclosure.
Tax Compliance Pattern Analysis: A Survey-Based Approach
Authors: Surugiu Marius-Răzvan , Vasile Valentina , Surugiu Camelia , Mazilescu Cristina Raluca , Panait Mirela-Clementina , Bunduchi Elena
Published: January 2025

This study investigates tax compliance patterns among individuals in Romania through a survey-based approach, aiming to comprehend factors influencing taxpayers’ behavior, including perception towards taxation, ethics, evasion, and public awareness. The insights garnered can inform policy decisions to enhance compliance rates. Additionally, it contributes to the tax compliance literature by examining unique Romanian context factors. The study delves into taxpayers’ opinions to discern specific views and behaviors within broader societal and economic transformations. A questionnaire was developed and administered online from April to June 2023, with a sample size of 185 respondents. A logistic regression model was constructed using the collected data to analyze the effects on tax compliance. The findings suggest that individuals comply with tax obligations when they perceive their contributions enhance public services and when the tax system aligns with their preferences. Surprisingly, a higher education level correlates with lower tax compliance, emphasizing the importance of targeted interventions and educational campaigns. This underscores the necessity for effective communication about the societal benefits of paying taxes. Policymakers should tailor awareness campaigns to inform higher-educated individuals about the significance of tax compliance and its impact on public goods. This ensures a more informed populace and promotes voluntary compliance with tax regulations.
NLRC3 Attenuates Antiviral Innate Immune Response by Targeting IRF7 in Grass Carp (Ctenopharyngodon idelus)
Authors: Zhang Lei , Chen Haitai , Zhao Xiang , Chen Youcheng , Li Shenpeng , Xiao Tiaoyi , Xiong Shuting
Published: January 2025

NLRC3 belongs to the NOD-like receptor family and is recognized as a modulator of innate immune mechanisms. In this study, we firstly report that Ctenopharyngodon idelus NLRC3 (CiNLRC3) acts as a negative regulator in the antiviral immune response. Cinlrc3 is ubiquitously expressed across tested tissues, displaying particularly high expression in the intestine, spleen, gill and kidney. Notably, Cinlrc3 expression is markedly upregulated following grass carp reovirus (GCRV) infection both in vivo and in vitro. Functional assays reveal that the overexpression of CiNLRC3 hampers cellular antiviral responses, thereby facilitating viral replication. Conversely, the silencing of CiNLRC3 through siRNA transfection enhances these antiviral activities. Additionally, CiNLRC3 substantially diminishes the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated interferon (IFN) response in fish. Subsequent molecular investigations indicates that CiNLRC3 interacts with the RLR molecule node, IRF7 but not IRF3, by degrading the IRF7 protein in a proteasome-dependent manner. Furthermore, CiNLRC3 co-localizes with CiIRF7 in the cytoplasm and impedes the IRF7-induced IFN response, resulting in impairing IRF7-mediated antiviral immunity. Summarily, these findings underscore the critical inhibitory role of teleost NLRC3 in innate immunity, offering new perspectives on its regulatory functions and potential as a target for resistant breeding in fish.
Lymphocyte Subset Imbalance in Cardiometabolic Diseases: Are T Cells the Missing Link?
Authors: Picone Francesca , Giudice Valentina , Iside Concetta , Venturini Eleonora , Di Pietro Paola , Vecchione Carmine , Selleri Carmine , Carrizzo Albino
Published: January 2025

Cardiometabolic and cardiovascular diseases (CVDs) remain the leading cause of death worldwide, with well-established risk factors such as smoking, obesity, and diabetes contributing to plaque formation and chronic inflammation. However, emerging evidence suggests that the immune system plays a more significant role in the development and progression of CVD than previously thought. Specifically, the finely tuned regulation of lymphocyte subsets governs post-injury inflammation and tissue damage resolution and orchestrates the functions and activation of endothelial cells, cardiomyocytes, and fibroblasts in CVD-associated lesions (e.g., atherosclerotic plaques). A deeper understanding of the immune system’s involvement in CVD development and progression will provide new insights into disease biology and uncover novel therapeutic targets aimed at re-establishing immune homeostasis. In this review, we summarize the current state of knowledge on the distribution and involvement of lymphocyte subsets in CVD, including atherosclerosis, diabetes, hypertension, myocardial infarction, and stroke.
Phylogenetic Relationship and Characterization of the Complete Mitochondrial Genome of the Cuckoo Species Clamator coromandus (Aves: Cuculidae)
Authors: Zhang Yu , Gao Hao , Zhang Fan , Xia Chengxing , Li Guopan , Li Shaobin
Published: January 2025

The chestnut-winged cuckoo (Clamator coromandus) is a bird species known for its brood parasitism, laying eggs in the nests of other bird species. However, there is a paucity of genetic information available for this species and their genus Clamator. In this study, we present the first complete mitochondrial genome sequence of C. coromandus and compare it with other species within the Cuculidae family. The mitogenome is a closed circular molecule consisting of 17,082 bp with an organization typical of the mitochondrial genomes of Cuculidae. Alignment of the control regions across Cuculidae species revealed substantial genetic variation and a significant abundance of AT content. A significant difference was detected in AT-skews between brood-parasitic and parental-care species. A distinctive long poly-C sequence was located at the 5′ end of domain I. Phylogenetically, C. coromandus is more closely related to Piaya cayana than Ceuthmochares aereus. The phylogenetic analysis indicated a general divergence between species with brood parasitism and those with parental care, with transitions between these behaviors within brood parasitism branches, suggesting multiple evolutionary occurrences of these traits. The complete mitogenome of C. coromandus serves as a valuable resource for further investigation into the taxonomic status and phylogenetic history of Clamator species.
Isolation and Characterization of the First Antigen-Specific EGFRvIII vNAR from Freshwater Stingray (Potamotrygon spp.) as a Drug Carrier in Glioblastoma Cancer Cells
Authors: Manzanares-Guzmán Alejandro , Alfonseca-Ladrón de Guevara Andrea C. , Reza-Escobar Elia , Burciaga-Flores Mirna , Canales-Aguirre Alejandro , Esquivel-Solís Hugo , Lugo-Fabres Pavel H. , Camacho-Villegas Tanya A.
Published: January 2025

Glioblastoma is the most common and highly malignant brain tumor in adults. New targeted therapeutic approaches are imperative. EGFRvIII has appealing therapeutic targets using monoclonal antibodies. Thus, endeavors toward developing new mAbs therapies for GBM capable of targeting the tumor EGFRvIII biomarker must prevail to improve the patient’s prognosis. Here, we isolated and characterized an anti-EGFRvIII vNAR from a non-immune freshwater stingray mixed library, termed vNAR R426. The vNAR R426 and pEGFRvIII interaction was demonstrated by molecular docking and molecular dynamics, and the recognition of EGFRvIII in vitro was further confirmed by cell immunofluorescence staining. Moreover, the vNAR R426 was shown to be an effective cisplatin drug carrier in the U87-MG glioma cell line. The cisplatin-coupled vNAR demonstrated highly significant differences when compared to free CDDP at 72 h. Notably, the cisplatin-vNAR carrier achieved better efficacy in the U87-MG cell line. Thus, we described the vNAR R426 internalization by receptor-mediated endocytosis and the subsequent COPI-mediated nuclear translocation of EGFRvIII and highlighted the importance of this shuttle mechanism to enhance the targeted delivery of cisplatin within the glioma cell’s nucleus and improved cytotoxic effect. In conclusion, vNAR R426 could be a potential therapeutic carrier for EGFRvIII-targeted glioblastoma and cancer therapies.
Evaluating the Anti-Inflammatory and Chondroprotective Effects of Adenocaulon himalaicum Extract Through Network Pharmacology and Experimental Validation
Authors: Lee Yun Mi , Son Eunjung , Kim Dong-Seon , Shim Kyu-Suk , Yu Su Hyun
Published: January 2025

Conventional osteoarthritis treatments have several side effects and poor efficacy. This study explored the anti-inflammatory and cartilage-protective effects of Adenocaulon himalaicum, with a focus on its potential application in osteoarthritis treatment. The anti-inflammatory effects of A. himalaicum extract (AHLE) were investigated in lipopolysaccharide-induced RAW264.7 macrophages, interleukin (IL)-1β-stimulated chondrocytes, and rats with carrageenan-induced hind paw oedema. We also evaluated AHLE’s analgesic activity in mice with acetic acid-induced writhing. The components of AHLE were subjected to network pharmacological analysis to elucidate their mechanisms of action and validate potential pathways and targets in vitro. AHLE markedly reduced nitric oxide, IL-1β, IL-6, tumour necrosis factor-alpha, and prostaglandin E2 production in both RAW264.7 macrophages and chondrocytes. In animal models, AHLE reduced carrageenan-induced hind paw swelling and provided analgesic effects in writhing tests. The main components were chlorogenic acid; 1,3-dicaffeoylquinic acid; 3,4-dicaffeoylquinic acid; 3,5-dicaffeoylquinic acid; and 4,5-dicaffeoylquinic acid. According to network pharmacological analysis, AHLE’s main therapeutic targets are the mitogen-activated protein kinase (MAPK) signalling pathway and extracellular matrix (ECM) degradation. These targets were verified through the MAPK pathway and expression of matrix metalloproteinase, an enzyme involved in ECM degradation. In conclusion, AHLE has considerable anti-inflammatory and cartilage-protective properties, making it a promising candidate for osteoarthritis therapy.
Biomass and Nutritional Status of Melon Hybrids Induced by Arbuscular Mycorrhizal Fungi Application Under Varying Irrigation Stress
Authors: Melo Juliana M. M. de , Marinho Lígia B. , Vargens Fernanda N. , Lopes Iug , Y. Melo Adriana M. , Martins Lindete M. V. , Vellame Lucas M. , Deon Magnus Dall Igna , Santos Danielle Karla Alves dos , Guimarães Miguel J. M.
Published: January 2025

Water scarcity is a major challenge in northeastern Brazil, where efficient water management strategies are essential for sustainable agriculture. This study aimed to evaluate the performance of melon hybrids in terms of biomass production and nutritional status under varying irrigation levels and mycorrhizal fungi (AMF) inoculation. The experiment was conducted in a greenhouse at the State University of Bahia (Juazeiro, BA, Brazil) using a randomized block design with a 4 × 2 × 4 sub-subdivided plot scheme. The treatments included four irrigation levels (50%, 75%, 100%, and 125% of crop evapotranspiration—ETc), two melon hybrids (Juazeiro and Mandacaru), and four AMF inoculation treatments (non-inoculated with AMF, Entrophospora etunicata, Acaulospora longula, and their combination), with 10 replications. The results indicated that the inoculation with A. longula significantly improved biomass production and plant nutrition, particularly for the Juazeiro hybrid. The most significant improvements were observed in biomass production and nutritional status when this mycobiont was used, highlighting the potential of AMF inoculation as a strategy to enhance water use efficiency and plant tolerance under water-limited conditions. Root colonization in melon plants ranged from 6% to 60%, with an overall average of 36.2%, in Experiment I, and from 6% to 72%, with an average of 40%, in Experiment II. Melon biomass production responded differently to irrigation levels, with Experiment I showing polynomial decreases in biomass as water levels decreased, while Experiment II exhibited linear increases in biomass with higher irrigation, likely influenced by supplementary fertilization. When evaluated, the levels of macronutrients present in the aerial part of the plants did not show significant differences for the treatments concerning the levels of P, K, and Mg, except for Ca. These findings suggest that A. longula is a suitable mycobiont for optimizing melon plant performance in regions with limited water resources, like northeastern Brazil. The study also emphasizes the importance of selecting appropriate Mycorrhizal fungi to maximize symbiotic benefits in melon cultivation under deficit irrigation systems.
Bioacaricides in Crop Protection—What Is the State of Play?
Authors: Marčić Dejan , Döker Ismail , Tsolakis Haralabos
Published: January 2025

Growing demands for environmentally safe and sustainable pest management have increased interest in biopesticides as alternatives to synthetic chemical pesticides. This review presents the current status of bioacaricides, defined as commercial biopesticide products based on microorganisms (microbial acaricides) and biologically active substances of microbial, plant or animal origin (biochemicals and semiochemicals) used in crop protection against spider mites (Tetranychidae) and other plant-feeding mites. The most important microbial bioacaricides are mycopesticides, which are products manufactured from living propagules of Beauveria bassiana s.l. and several other acaropathogenic fungi. Products based on avermectins and milbemycins, secondary metabolites of actinomycetes, are well-known examples of biochemicals of microbial origin. Among the biochemicals of plant origin, the most widely used to date have been the products based on pyrethrum—obtained from the Dalmatian daisy, Tanacetum cinerariifolium (Asteraceae)—and azadirachtin, obtained from the Indian neem tree, Azadirachta indica (Meliaceae). In recent years, products based on essential oils from aromatic plants belonging to the families Lamiaceae, Myrtaceae, Rutaceae and others have also gained increasing importance in the market. Special emphasis in this review is given to the compatibility of bioacaricides with predatory mites of the family Phytoseiidae as biological control agents used in the integrated management of plant-feeding mites.
Coronary Artery Disease in Very Young Women: Risk Factors and Prognostic Insights from Extended Follow-Up
Authors: Pintos-Rodríguez Samuel , Jiménez Díaz Víctor Alfonso , Veiga César , Martínez García Carlos , Caamaño Isorna Francisco , Íñiguez Romo Andrés , Juan-Salvadores Pablo
Published: January 2025

Coronary artery disease (CAD) is usually associated with the elderly, but an increase in its incidence has been recently reported among young people, including very young women. The aim of this study is to assess the associations between different clinical variables and the risk of early CAD and occurrence of major adverse cardiovascular events (MACEs) during follow-up. Our cohort consists of women ≤40 years referred for coronary angiography due to suspicion of CAD; a nested case–control study was conducted among these patients. In total, 19,321 coronary angiographies were performed between 2006 and 2015, of which 2.6% were in patients ≤40 years old; 52 women were finally included. Family history of CAD was strongly associated with the early onset of the disease [OR 5.94, 95%CI (1.13–31.15); p = 0.035] in young women. The incidence of MACE was also associated with depression [HR 8.20 95%CI (1.03–65.17); p = 0.047] and Castelli Index [HR 11.49, 95%CI (1.40–94.51); p = 0.023]. Primary prevention focused on genetic analysis for high-risk women with a family history of CAD and secondary prevention, targeting a better cholesterol management and mental health assistance must be considered.
The Differentiation and Regeneration Potential of ABCB5+ Mesenchymal Stem Cells: A Review and Clinical Perspectives
Authors: He Zheng , Starkuviene Vytaute , Keese Michael
Published: January 2025

Mesenchymal stem cells (MSCs) are a family of multipotent stem cells that show self-renewal under proliferation, multilineage differentiation, immunomodulation, and trophic function. Thus, these cells, such as adipose tissue-derived mesenchymal stem cells (ADSCs), bone marrow-derived MSCs (BM-MSCs), and umbilical cord-derived mesenchymal stem cells (UC-MSCs), carry great promise for novel clinical treatment options. However, the challenges associated with the isolation of MSCs and the instability of their in vitro expansion remain significant barriers to their clinical application. The plasma membrane-spanning P-glycoprotein ATP-binding cassette subfamily B member 5 positive MSCs (ABCB5+ MSCs) derived from human skin specimens offer a distinctive advantage over other MSCs. They can be easily extracted from the dermis and expanded. In culture, ABCB5+ MSCs demonstrate robust innate homeostasis and a classic trilineage differentiation. Additionally, their ability to modulate the recipients’ immune system highlights their potential for allogeneic applications in regenerative medicine. In this review, we primarily discuss the differentiation potential of ABCB5+ MSCs and their perspectives in regenerative medicine.
Five-Year Comparative Study of Zygomatic and Subperiosteal Implants: Clinical Outcomes, Complications, and Treatment Strategies for Severe Maxillary Atrophy
Authors: Zielinski Rafal , Okulski Jakub , Piechaczek Martyna , Łoś Jan , Sowiński Jerzy , Sadowska-Sowińska Monika , Kołkowska Agata , Simka Wojciech , Kozakiewicz Marcin
Published: January 2025

Background/Objectives: Severe maxillary atrophy presents challenges in maxillofacial rehabilitation. This study compares the clinical outcomes of zygomatic and subperiosteal implants, focusing on implant survival, soft tissue management, and postoperative complications over a five-year follow-up. Methods: A retrospective cohort study analyzed 150 patients divided into two groups based on the type of implant. Zygomatic implants were assessed for immediate functional loading, procedural efficiency, and complications such as sinus-related issues and orbital damage. Subperiosteal implants were evaluated for their customized design, keratinized mucosa integration, and adaptation to severe anatomical limitations. Statistical analyses, including Chi-square tests, were used to determine significant differences (p < 0.05). Results: This study demonstrated differences in complication rates (sinus-related complications: 12.4% for zygomatic implants; peri-implantitis: 5.6% for subperiosteal implants). Implant survival rates were comparable (zygomatic: 96.3%, subperiosteal: 97.1%, p = 0.278). Zygomatic implants demonstrated higher incidences of sinus-related complications (12.4%) and risks of orbital damage. Subperiosteal implants exhibited superior soft tissue stability with fewer cases of peri-implantitis (5.6%, p < 0.05). Procedural duration was shorter for zygomatic implants (177 min vs. 123 min); however, subperiosteal implants allowed for re-implantation after failure, providing flexibility that was unavailable with zygomatic implants. Conclusions: Zygomatic implants excel in immediate functional loading and reduced procedural time but require advanced surgical expertise to mitigate anatomical risks. Subperiosteal implants offer a safer, customizable solution, particularly in anatomically complex cases. These findings emphasize the importance of individualized treatment planning and technological advancements in implant design to optimize clinical outcomes for patients with severe maxillary atrophy.
Impact of Internal Solitary Wave on Acoustic Propagation Based on Coupled Normal Mode Theory
Authors: Liu Zhuolong , Zhang Yongchui , Gao Fei , Zhang Yunxiang , Wang Yang , Hong Mei
Published: January 2025

An internal solitary wave (ISW) significantly affects acoustic propagation; however, its detailed characteristics are poorly understood. Simulation experiments of sound propagation in a shallow water environment are presented to examine the effects of the source conditions and characteristics of the ISW on transmission loss (TL). The results show that the TL decreases as the depth of the source increases and the frequency of the source decreases and that the different characteristics of the ISW are highly important for estimating sound propagation when a SONAR system is in an ISW environment. Coupled normal mode theory is further employed to analyse the variations in coupling between sound field modes in an ISW environment. Further analysis reveals that the magnitude of the TL is affected by the direction and fluctuation of energy propagation between different modes, and in different ISW environments under the deep and low-frequency source conditions, the sound field energy is mainly in lower-order modes.
Optimization of Configuration Design for Underwater Dam Defect Detection Vehicles
Authors: Cheng Hong-Xia , Cao Mei-Jie , Xu Peng-Fei , Kai Yan , Wang Zi-Peng , Wan Gang , Hu Qiao
Published: January 2025

Hydropower stations and dams play a crucial role in water management, ecology, and energy. To meet the requirements of underwater dam defect detection, this study develops a streamlined underwater vehicle design and operational framework inspired by bionic principles. A parametric modeling approach was employed to propose the vehicle’s streamlined configuration. Using CFD simulations, hydrodynamic coefficients were calculated and validated through towing experiments in a pool. The hydrodynamic stability of the vehicle was assessed and verified through these analyses. Additionally, various configurations were generated using a free deformation method. An optimization function was established with resistance and stability as the objectives, and the optimal result was derived based on the function’s calculation outcomes. The study designed a high-metacentric underwater vehicle, inspired by the seahorse’s shape, and introduced a novel stability evaluation method. Simulations were conducted to analyze the vehicle’s variable attack angle, drift angle, pitching, and rotational motion at a forward three-throttle speed. The results demonstrate that the vehicle achieves static stability in both the horizontal and vertical planes, as well as dynamic stability in the vertical plane, but exhibits limited dynamic stability in the horizontal plane. After optimizing the original configuration, the forward resistance was reduced by 2.15%, while the horizontal plane dynamic stability criterion CH was improved by 35.29%.
Impacts of Physical Parameterization Schemes on Typhoon Doksuri (2023) Forecasting from the Perspective of Wind–Wave Coupling
Authors: Li Lihua , Peng Bo , Wang Weiwen , Chang Ming , Wang Xuemei
Published: January 2025

Tropical cyclones (TCs) form over warm ocean surfaces and are driven by complex air–sea interactions, posing significant challenges to their forecasting. Accurate parameterization of physical processes is crucial for enhancing the precision of TC predictions. In this study, we employed the Weather Research and Forecasting model coupled with the Simulating Waves Nearshore (WRF-SWAN) model to forecast Typhoon Doksuri (2023), which exhibited a secondary intensification process in the South China Sea (SCS). We also investigated its sensitivity to various atmospheric physical parameterization schemes (PPS). The findings indicate that improvements in microphysical and cumulus convection parameterizations have significantly enhanced the prediction accuracy of Typhoon Doksuri’s trajectory and intensity. The simulation of sea surface heat flux is primarily influenced by the microphysical scheme, while the cumulus convection scheme substantially affects the representation of the typhoon core’s size and shape. Variations in the wind field induce differences in wave height, potentially reaching up to 2–3 m at any given moment. This study provides valuable insights into the effective selection of physical parameterizations for improving typhoon forecasts.
Defining the Predictors of Financial Literacy for High-School Students
Authors: Tzora Vasiliki A.
Published: January 2025

This work documents the significant predictors of financial literacy of high-school students across Greece. The results derived, from the examined aspects of financial knowledge, financial behaviour, and financial attitude, the determinants of financial literacy that high-school students demonstrated. A novel approach whereby a canonical analysis is applied to financial literacy data. The findings reveal that better-performing students, students with parents with a university degree, students’ perception of parents’ income, and students who keep records of their income and expenses are significant predictors of financial literacy. The results of this analysis should be considered when building financial education initiatives to embrace the young generation.
Promoting Equal Protection and Regulatory Remedies for Balanced Civic Education
Authors: Humlen Peder
Published: January 2025

This article examines the teaching of civic engagement in academic settings, focusing on its role in generating new knowledge and fostering social and personal action. The article proposes regulatory remedies to ensure a fair and balanced curriculum supporting diverse worldviews and productive discourse, promoting student civic participation. The legal principle of equal protection, enshrined in the Fourteenth Amendment, serves as the foundation. The Fourteenth Amendment emphasizes equal treatment and opportunities for all, including access to a well-rounded education. By incorporating its principles into education, the article highlights the need to promote fair, civic education that empowers all students to participate actively in their communities. I recommend regulatory remedies to solidify education’s nature and foster a balanced curriculum. The proposed remedies ensure that various worldviews are embraced, promoting productive and amicable discourse among students. Creating an inclusive learning environment also allows students to engage in critical thinking and develop a deeper understanding of diverse perspectives, ultimately enhancing their civic participation. Furthermore, the article emphasizes the importance of regulatory safeguards against biased or exclusionary educational practices to ensure that all students have equal educational opportunities, regardless of their background or beliefs. By eliminating barriers and promoting a fair educational system, students can develop the necessary knowledge and skills to contribute to their communities actively. By incorporating the legal principle of equal protection with respect to perspectives represented on campus, the article advocates for legal and regulatory remedies to promote a fair and balanced curriculum that supports diverse worldviews.
Effects of Biochar Addition on the Properties of Alkali-Activated Materials
Authors: Saccani Andrea , Baldazzi Luca , Manzi Stefania
Published: January 2025

The addition of biochar to Portland cement composites has been proven to increase some of the material properties. The effect on alkali-activated materials has not been fully investigated. In this study, different recipes of metakaolin pastes at different biochar amounts are tested. Their physical and mechanical properties are analyzed to understand if any beneficial effects can be found even for alkali-activated binders. The results show that the addition of small amounts of biochar (<2 wt%) increases the compressive strength of metakaolin pastes (+15% after 28 days) and decreases the water absorption by capillarity, possibly leading to increased durability. Higher biochar content decreases the mechanical properties but provides higher dimensional stability and reduces the formation of efflorescence.
A Comparative Study of New Ratio-Type Family of Estimators Under Stratified Two-Phase Sampling
Authors: Alghamdi Abdulaziz S. , Alrweili Hleil
Published: January 2025

Two-phase sampling is a useful technique for sample surveys, particularly when prior auxiliary data is not accessible. The ranks of the auxiliary variable often coincide with those of the research variable when two variables are correlated. By considering this relationship, we can significantly increase estimator accuracy. In this paper, we use the ranks of the auxiliary variable along with extreme values to estimate the population mean of the study variable. Up to a first-order approximation, we analyze the characteristics of the suggested class of estimators with an emphasis on biases and mean squared errors in stratified two-phase sampling. The theoretical results are verified using different datasets and a simulation study, which demonstrates that the proposed estimators outperform the existing ones in terms of percent relative efficiency.
Hybrid CNN-BiLSTM-MHSA Model for Accurate Fault Diagnosis of Rotor Motor Bearings
Authors: Yang Zizhen , Li Wei , Yuan Fang , Zhi Haifeng , Guo Min , Xin Bo , Gao Zhilong
Published: January 2025

Rotor motor fault diagnosis in Unmanned Aerial Vehicles (UAVs) presents significant challenges under variable speeds. Recent advances in deep learning offer promising solutions. To address challenges in extracting spatial, temporal, and hierarchical features from raw vibration signals, a hybrid CNN-BiLSTM-MHSA model is developed. This model leverages Convolutional Neural Networks (CNNs) to identify spatial patterns, a Bidirectional Long Short-Term Memory (BiLSTM) network to capture long- and short-term temporal dependencies, and a Multi-Head Self-Attention (MHSA) mechanism to highlight essential diagnostic features. Experiments on raw rotor motor vibration data preprocessed with Butterworth band-stop filters were conducted under laboratory and real-world conditions. The proposed model achieves 99.33% accuracy in identifying faulty bearings, outperforming traditional models like CNN (93.33%) and LSTM (62.00%) and recent advances including CNN-LSTM (98.87%), the Attention Recurrent Autoencoder hybrid Model (ARAE) (66.00%), Lightweight Time-focused Model Network (LTFM-Net) (96.67%), and Wavelet Denoising CNN-LSTM (WDCNN-LSTM) (96.00%). The model’s high accuracy and stability under varying conditions underscore its robustness, making it a reliable solution for rolling bearing fault diagnosis in rotor motors, particularly for dynamic UAV applications.
Efficient Synthesis of Fused Polycyclic Ether Systems via Sulfonium Ylides: A Synthetic Approach to Yessotoxin and Adriatoxin
Authors: Moya-Utrera Federico , Cheng-Sánchez Iván , Fuentes-Pino Irama , Sánchez-Ruiz Antonio , Sarabia Francisco
Published: January 2025

A novel class of chiral sulfonium salts, derived from L- and D-methionine, was designed and successfully employed for the diastereoselective synthesis of epoxy amides. This new methodology of asymmetric epoxidation was exploited for the stereoselective construction of fused polycyclic ethers, which are structural motifs present in a great variety of natural products of marine origin. This methodology proved to be useful for the synthesis of the tricyclic A–C system contained in yessotoxin and adriatoxin, and also in many other related natural products of marine origin belonging to the fused polycyclic ether toxins.
An Unusual Case of Metastatic Gastric Cancer Presenting with Right Heart Failure and Cardiac Metastasis
Authors: Engin Delipoyraz Ebru , Mildanoglu Maral Martin , Sürül Barış , Olmuşçelik Oktay , Erkanlı Korhan , Bilici Ahmet
Published: January 2025

Cardiac metastasis is rarely detected in oncology practice. Herein we present a rare case of metastatic gastric cancer that metastasized to the right atrium and presented with right heart failure. A 51-year-old male patient with no known chronic disease presented with fatigue, abdominal distension and leg edema for 3 weeks. Physical examination revealed abdominal ascites, tachycardia and pretibial edema. Transthoracic echocardiography (TTE) revealed a hypoechoic, less-mobile mass that almost completely filled the right atrium. Moreover, 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) showed metastatic lesions and a primary tumor-suspicious area in the esophagogastric component. Upper GI endoscopic evaluation performed on the patient revealed an ulcerovegetating mass consistent with gastric adenocarcinoma. A human epidermal growth factor receptor 2 (HER-2) was positiveand programmed death-ligand 1 (PD-L1) combined positive score (CPS) was detected as 15 in immunohistochemistry (IHC). Thereafter, an anticoagulant treatment was started including pembrolizumab and trastuzumab every three weeks, and an oxaliplatin and 5-FU-based chemotherapy regimen was started every two weeks. There was no regression in the cardiac lesion during follow-up; thereafter, there was a significant risk of cardioembolic complications, and a 10 × 7 cm mass filling the right atrium and adhering to the inferior vena cava was resected. The pathology results of the excision material reported gastric carcinoma metastasis. Systemic evaluation performed 3 months later showed regression in primary and metastatic lesions. Cardiac metastases are rare and may not be discovered until autopsy due to the prominence of primary disease findings. Cardiac metastasis, although rare, should be kept in mind in gastric cancer patients presenting with heart failure.
The Impact of Palliative and End-of-Life Care Educational Intervention in Emergency Departments in Singapore: An Interrupted Time Series Analysis
Authors: Yash Pal Rakhee , Chua Mui Teng , Guo Liang , Kumar Ranjeev , Shi Luming , Kuan Win Sen
Published: January 2025

Background and Objectives: The increasing prevalence of end-of-life care needs in the emergency department necessitates training for emergency staff in managing terminal symptoms, facilitating serious illness conversations and ensuring goal-concordant interventions. This study aims to evaluate the longitudinal effects of an end-of-life care educational intervention on various emergency professionals. Materials and Methods: An interrupted time series study was conducted among emergency physicians and nurses at three public healthcare institutions over two-and-a-half years. The study had three phases: Phase 1—5 pre-intervention surveys, Phase 2—intervention with an online training course, and Phase 3—5 post-intervention surveys. The impact of the intervention was scored based on staff perceptions of end-of-life care in 3 domains: 1. Knowledge of palliative care (Knowledge), 2. Quality of end-of-life care provided (Care), and 3. Ability to communicate with patients and families (Communication). Results: There were 990 participants with 6450 questionnaires distributed and an 87% response rate of completed questionnaires. Phase 3 had generally higher levels of agreement in all 3 domains compared to Phase 1, with a continued upward trend in Knowledge scores. Upward trends in the Care and Communication domains were less pronounced. Among the 631 (out of 990) participants who completed the training, test scores showed a median improvement of 37.5% (p < 0.001). Conclusions: This study supports the feasibility of online end-of-life care training tailored specifically for emergency professionals, with promising results in the Knowledge, Care, and Communication domains. The findings can help guide the further development of training programs or the adoption of similar interventions for basic palliative care training for emergency physicians and nurses.
Phase Transitions and Structural Evolution of Manganese Ores During High-Temperature Treatment
Authors: Safarov Ruslan Z. , Baikenov Yerlan A. , Zhandildenova Assemgul K. , Kopishev Eldar E. , Kamatov Ruslan M. , Kargin Jumat B. , Sanchez Cornejo H. , Barnes Crispin H. W. , De Los Santos Valladares Luis
Published: January 2025

The aim of this research is to investigate the phase composition and structural peculiarities of complex metamorphic manganese ores from Central Kazakhstan before and after sintering in the temperature range of 600–1200 °C in an air atmosphere. X-ray diffraction, X-ray fluorescence, scanning electron microscopy, and optical microscopy were used to analyze changes in elemental and phase composition. In their initial state, according to XRF analysis, the Bogach ore was manganese-rich, with a manganese content of 60.77 wt.%, while the Zhaksy ore contained manganese (44.88 wt.%), silicon (20.85 wt.%), and iron (6.14 wt.%) as its main components. In the Bogach ore samples, manganese content increased from 60.77% to 65.7% as the sintering temperature rose to 1100 °C, while the hausmannite phase (Mn3O4) emerged as the dominant phase, comprising 95.77% of the crystalline component at 1200 °C. Conversely, the Zhaksy ore samples displayed a sharp increase in braunite-phase (Mn7O12Si) content, reaching 83.81% at 1100 °C, alongside significant quartz amorphization. The degree of crystallinity in Bogach ore peaked at 56.2% at 900 °C but declined at higher temperatures due to amorphous phase formation. A surface morphology analysis revealed the transformation of dense, non-uniform particles into porous, granular structures with pronounced recrystallization as the temperature increased. In the Bogach samples, sintering at 900 °C resulted in elongated, needle-like crystalline formations, while at 1200 °C, tetragonal crystals of hausmannite dominated, indicating significant grain growth and recrystallization. For Zhaksy samples, sintering at 1100 °C led to a porous morphology with interconnected grains and microvoids, reflecting enhanced braunite crystallization and quartz amorphization. These findings provide quantitative insights into optimizing manganese oxide phases for industrial applications, such as catalysts and pigments, and emphasize the impact of thermal treatment on phase stability and structural properties. This research contributes to the development of efficient processing technologies for medium-grade manganese ores, aligning with Kazakhstan’s strategic goals in sustainable resource utilization.
Investigation of Modal Characteristics of Silicon Nitride Ridge Waveguides for Enhanced Refractive Index Sensing
Authors: Butt Muhammad A. , Kozlowski Lukasz , Słowikowski Mateusz , Juchniewicz Marcin , Drecka Dagmara , Filipiak Maciej , Golas Michał , Stonio Bartłomiej , Dudek Michal , Piramidowicz Ryszard
Published: January 2025

This paper investigates the wavelength-dependent sensitivity of a ridge waveguide based on a silicon nitride (Si3N4) platform, combining numerical analysis and experimental validation. In the first part, the modal characteristics of a Si3N4 ridge waveguide are analyzed in detail, focusing on the effective refractive index (neff), evanescent field ratio (EFR), and propagation losses (αprop). These parameters are critical for understanding the interplay of guided light with the surrounding medium and optimizing waveguide design for sensing applications. In the second part, the wavelength-dependent sensitivity of a racetrack ring resonator (RTRR) based on the Si3N4 waveguide is experimentally demonstrated. The results demonstrate a clear increase in the sensitivity of the RTRR, rising from 116.3 nm/RIU to 143.3 nm/RIU as the wavelength shifts from 1520 nm to 1600 nm. This trend provides valuable insights into the device’s enhanced performance at longer wavelengths, underscoring its potential for applications requiring high sensitivity in this spectral range.
Characterization of Conjunctival Microflora and Antibiotic Sensitivity Patterns in Patients Undergoing Cataract Surgery
Authors: Vagge Aldo , Lixi Filippo , Ponzin Diego , Del Noce Chiara , Camposampiero Davide , Santocono Marcello , Traverso Carlo Enrico , Scorcia Vincenzo , Giannaccare Giuseppe
Published: January 2025

This study aims to characterize the conjunctival flora of patients scheduled for cataract surgery and determine the susceptibility profile of isolated bacteria to several commonly used topical antibiotics. Conjunctival swabs were taken from 44 consecutive patients (25 males, 19 females; mean age of 75.0 ± 12.6 years) who were scheduled for senile cataract surgery at two Italian centers before starting any prophylactic preoperative treatment. Swabs were processed for the detection of the microbial growth and for species identification. Selective culture media were used, and bacteria were identified using the MicroScan Specialty ID Panels (Beckman Coulter®, Brea, CA, USA). Antimicrobial susceptibility for the following antibiotics (netilmicin, tobramycin, ofloxacin, oxacillin, levofloxacin, moxifloxacin, chloramphenicol, cefuroxime, and azithromycin) were assessed using the Kirby–Bauer disk diffusion method. Susceptibility for oxacillin was useful to identify methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE). Among the swabs analyzed, 61.4% showed only saprophytic flora, 30.7% showed only potential pathogenic flora, and 8.0% showed mixed flora. S. epidermidis (20.5%), S. intermedius (18.2%), and S. aureus (14.8%) were the most frequent isolates; MRSA and MRSE accounted for 8.0% and 6.8% of isolates. Less frequently (9%), Gram-negative bacteria such as Pseudomonas fluorescent, Serratia marcescens, Moraxella lacunata, Morganella morgani, and Stenotrophomonas maltophila were detected. All isolated organisms showed an excellent sensitivity to moxifloxacin and chloramphenicol (range 83–100%, range 67–100%, Gram-positive sensitivity for moxifloxacin and chloramphenicol, respectively; 100% Gram-negative sensitivity for both). A significant percentage of the eyes of candidates for surgery presented potential pathogenic flora alone or in association with saprophytic organisms. Staphylococci were the most frequently isolated bacteria. Tobramycin and Ofloxacin, widely used in the ophthalmic field, are confirmed to have a reduced sensitivity in vitro.
Temperature: An Influencing Factor on the Rheological and Energetic Parameters of Acid Pressure Technology Operations
Authors: Hernández-Ramírez Gabriel , Bernardo-Sánchez Antonio , Legrá-Lobaina Aristides Alejandro , Álvarez de Prado Laura , Martínez-Rojas Rodney , Pérez-García Liudmila , Garcell-Puyáns Leonel , Fernández-Ordás Jose , Menéndez Javier
Published: January 2025

In this work, a study was carried out on the effect of temperature as the main influencing factor on the rheological behavior of lateritic suspensions, raw material for the operations of pressurized acid technology (HPAL) used to obtain nickel and cobalt from of oxidized ores. From studies of X-ray diffraction, X-ray fluorescence, particle size analyzer, and mathematical modeling, the behavior of the interactions and rheological characteristics of the analyzed samples were obtained. In this study, it was concluded that the use of mathematical models that relate the temperature up to 90 °C and the energy parameters of the pumping system of flows, loads, hydraulic losses, power, and efficiency would allow finding ways to increase and stabilize the flow of fed hydromixture with a flow rate of 1600 m3/h and a solids concentration of 48% (w/w) and guarantee the efficiency of the technological process.