bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PENAMBAHAN KITOSAN TERHADAP CEMARANMIKROBIOLOGIS PADA ABON PINDANG TONGKOL (Euthynnus affinis)
Authors: Kusumaningsih Purwaningtyas
Published: August 2022

Pengolahan ikan pindang menjadi abon merupakan teknologi pangan bertujuan memperpanjang masa simpan. Penambahan kitosan pada abon berfungsi untuk mencegah berkembangnya bakteri Vibrio sp., Proteus sp., dan Pseudomonas sp. Bakteri-bakteri ini hidup di lingkungan berkadar garam tinggi, seperti pada produk ikan pindang. Tujuan dari penelitian ini adalah untuk menguji efek penambahan kitosan terhadap kuantitas Vibrio sp., Proteus sp., dan Pseudomonas sp. pada olahan ikan pindang tongkol. Pada penelitian ini dilakukan pengujian terhadap sampel ikan pindang tongkol, abon tanpa kitosan dan abon dengan penambahan 50 mg kitosan. Total plate count (TPC) pada ikan pindang dilaporkan terlalu banyak untuk dihitung (TBUD). TPC pada abon tanpa kitosan dan abon berkitosan adalah kurang dari 2,5 × 102 koloni/ml (g). Nilai ini memenuhi Standar Nasional Indonesia (SNI) 7690.1:2013 dan hasil ini menunjukkan bahwa pengolahan ikan pindang tongkol menjadi abon serta penambahan kitosan dapat mengurangi cemaran bakteri. Identifikasi bakteri menggunakan media Thiosulfate Citrate Bile Salt Sucrose (TCBS), pengecatan gram dan kit API 20E. Bakteri yang teridentifikasi pada ikan pindang adalah Proteus vulgaris, sedangkan Pseudomonas luteola teridentifikasi pada abon tanpa kitosan. Penambahan kitosan 50 mg didalam abon terbukti mencegah perkembangan bakteri halofilik seperti Vibrio sp., Proteus sp., dan Pseudomonas sp.
Intrusion Detection in Internet of Things Environment
Authors:   Industrial University of Ho Chi Minh City, Ho Chi Minh, Vietnam, Dang Quang-Vinh
Published: August 2022

Internet of Things (IoT) attracted a lot of attention in recent years. IoT introduces many new opportunities but also pose a lot of vulnerabilities. When any smart devices can connect to the Internet, attackers can attack to the system via any point. Hence, studying the intrusion detection technique for IoT environment is a crucial task. In this chapter, we study the intrusion detection problem in IoT environment.
Use of digital technologies to improve the classical methodology of foreign language teaching in professional educational organizations
Authors:   Nizhny Novgorod State Engineering and Economic University, Russia, Bykova Dary , Zhdankina Irina ,   Nizhny Novgorod State Engineering and Economic University, Russia, Ignatieva Natalia ,   Nizhny Novgorod State Engineering and Economic University, Russia, Belousova Olga ,   Nizhny Novgorod State Engineering and Economic University, Russia, Polyakov Valery ,   Nizhny Novgorod State Engineering and Economic University, Russia
Published: August 2022

This chapter is devoted to the study, analysis of the effectiveness of the use of the methodology, as well as the development of a model for improving the classical methodology of teaching a foreign language in the specialties of vocational education of various technical profiles with elements of digitalization. A brief overview of the available training methods is made, an analysis of the regulatory framework is carried out. A model of teaching a foreign language has been developed and experimentally substantiated. The main element of digitalization is the author's developed online course "Foreign language", attached to the educational platform Moodle.
Hattat Hâmid Aytaç'ın Hayatı ve Şişli Camii'ndeki Hat Eserleri
Authors: Gemici Nurettin , Deri Mehmet
Published: August 2022

Hâmid Aytaç, son Osmanlı-Türk hattatı olmasının yanı sıra, hat sanatında Osman ile Cumhuriyet Türkiye’si arasında köprü vazifesi gören hem eserleri hem de yurt içinde ve yurt dışında yetiştirdiği binlerce öğrencisi ile sanatının zirvesinde yer almış bir şahsiyettir. Karşılaştığı zorluklar onun gözünü yıldırmamış ve eğitiminde istediği biçimde ilerlemiş olmasa da mesleğinde zirveye ulaşmıştır. Üstad Hâmid Aytaç, Harf İnkılâbına (1928) kadar Yazı Yurdu olarak bilinen yerde matbaacılık, klişecilik, çinkografi, pantografi, mâmul maddeler için lüks etiket ve kartvizit basımı işleriyle meşgul olmuştur. Harf İnkılâbından sonra Türkiye’de öğrenmekten veya uğraşı vermekten kaçındığı yüzyılların birikimi olan Hat sanatını, gelen talepler üzerine çoğunluğu Arap ülkelerinden olan talebelerine öğretmiştir. Bu vesileyle Şişli Camii’nin inşasında büyük rolü olan Mimar Vasfi Egeli’den de bahsetmemek olmaz. Mimar Kemaleddin ve Mimar Vedat beylerin öğrencisi olan Egeli, Şişli Camiini neo-klasik üslupta yapmıştır. Şişli Camii’nin, döneminde uzun bir aradan sonra yapılan bir cami oluşu, yeni kurulan bir semtte buna duyulan ihtiyaç ve bu hassasiyete sahip insanlarla da doğrudan alâkalıdır. Şişli Camii inşa faaliyetleri bile ayrı bir çalışma konusu olacak kadar kapsamlı ve geniştir.1950 sonrası ülkemizde görülen demokratik havanın da tesiriyle, sanatını eski ve yeni yapılan camilerde gösterme imkânı bulmuştur. Bunlardan birisi olan İstanbul’daki Şişli Camiindeki yazıları da büyük önem arz etmektedir. Özellikle Şişli Camii kapısı üzerindeki celî sülüs müsennâ istifi dünyaca ünlüdür. Camideki yazılar, Hâmid Hocanın kendisinin de bizzat övgüyle bahsettiği yazılardır. Hayatında bu kadar önemli yer tutan Şişli Camii’nin bir de bu yönüyle tanıtılması bu büyük hattata ve Diyarbakır’ın öz evlâdına saygının da bir tezâhürü olacaktır
İlahiyat Fakültelerinin Arapça Hazırlık Sınıflarında Görev Yapan Öğretim Elemanlarının Mesleki Eğitim Gereksinimleri
Authors: Dündar Ahmet İhsan , Mohamed Ali Ahmed Hassan
Published: August 2022

Bu çalışma Türkiye’deki ilahiyat fakültelerinde görev yapmakta olan Arap dili öğretim elemanlarının hali hazırdaki eğitsel yeterlilik durumunu ve Arapça konuşmayan öğrencilere bu dili öğreten öğretim elemanlarında bulunması gerekli olan mesleki yeterliliklerin ve ayrıca bu yeterlilikler çerçevesindeki eğitsel gereksinimlerinin tespitini yapmayı hedeflemektedir.
Çalışmayı yürüten araştırmacılar söz konusu amaçları gerçekleştirmek üzere eğitimle ilgili literatür taraması yapmak suretiyle gerekli olan mesleki yeterliliklere dair bir liste oluşturmuşlardır. Ardından anket soruları hazırlayarak değerlendirmede bulunmaları için konunun uzmanlarına sunmuşlar ve gelen yanıtlar doğrultusunda söz konusu sorularda yapılan değişiklikler sonrasında anket uygulamasında bulunmuşlardır. Anket uygulamasına örneklem olarak Arap ve Türk uyruklu öğretim elemanlarından 70 kişi katılmıştır. Çalışmanın sonucunda Türkiye’deki ilahiyat fakültelerinde görev yapan öğretim elemanlarının reel durumuna ilişkin analizi de içeren bazı sonuçlar elde edilmiş, önerilerde bulunulmuştur. Ayrıca öğretim elemanları için gerekli görülen ve eğitim programlarına dâhil edilmesi önerilen eğitsel gereksinimlere dair bir liste oluşturulmuştur.
Tekvîr, İnfitâr ve İnşikâk Surelerinde Zikredilen Kıyametin Kopuş Tasvirlerinin Teolojik ve Lugavî İncelemesi
Authors: Soğukoğlu Fehmi , Elnecer Muhammed
Published: August 2022

Âhiret hayatının başlangıcı olarak nitelenebilecek kıyametle ilgili Kur’ân-ı Kerîm’de birçok surede çeşitli bilgilere yer verilmektedir. İnanç temellerini oluşturmaya yönelik ifadelerin daha fazla yer aldığı Mekkî surelerde bu hususun daha fazla ön plana çıktığını kaydedebiliriz. Makalede Mekkî olan ve kıyamet tasvirlerinin yoğun bir şekilde yer aldığı Tekvîr, İnfitâr ve İnşikâk surelerinde geçen kıyametin kopuş anında veya yeniden diriliş zamanı yaşanacak hadiseler, Kelâm ve Arap dili disiplinleri ekseninde incelenmiştir. Bu üç sure arasında konu açısından bir bağlantı bulunduğu ve surelerin diziliş sıralamasının birbirini tamamladığı görülmektedir. Bu bağlamda bu surelerin birlikte ele alınmasının önemli olduğu kaydedilebilir. Üç surenin de إذا şart edatıyla başlaması belâgat açısından ilgi çekicidir. Zaman zarfı olan bu edat yaygın kullanım şeklinde ihtimal anlamı barındırsa da Allah’ın ilminin kuşatıcılığı dikkate alındığında ilahî haberler açısından kesinlik ifade etmektedir. Kıyamet anlatımlarında yer alan fiillerin daha çok geçmiş zaman oluşu bu hadiselerin muhakkak vâkî olacağıyla açıklanmaktadır. Çalışmada ayrıca ilgili sureler bağlamında kıyametin kopuşu esnasında yaşanacağı belirtilen hadiselerle yeniden diriliş anında olacağı bildirilen olaylar ayrıştırılarak tespit edilmeye çalışılmıştır
Noninvasive Low-Intensity Focused Ultrasound Mediates Tissue Protection following Ischemic Stroke
Authors: Kaloss Alexandra M. , Arnold Lauren N. , Soliman Eman , Langman Maya , Groot Nathalie , Vlaisavljevich Eli , Theus Michelle H.
Published: August 2022

Objective and Impact Statement
. This study examined the efficacy and safety of pulsed, low-intensity focused ultrasound (LIFU) and determined its ability to provide neuroprotection in a murine permanent middle cerebral artery occlusion (pMCAO) model.
Introduction
. Focused ultrasound (FUS) has emerged as a new therapeutic strategy for the treatment of ischemic stroke; however, its nonthrombolytic properties remain ill-defined. Therefore, we examined how LIFU influenced neuroprotection and vascular changes following stroke. Due to the critical role of leptomeningeal anastomoses or pial collateral vessels, in cerebral blood flow restoration and tissue protection following ischemic stroke, we also investigated their growth and remodeling.
Methods
. Mice were exposed to transcranial LIFU (fundamental frequency: 1.1 MHz, sonication duration: 300 ms, interstimulus interval: 3 s, pulse repetition frequency: 1 kHz, duty cycle per pulse: 50%, and peak negative pressure: -2.0 MPa) for 30 minutes following induction of pMCAO and then evaluated for infarct volume, blood-brain barrier (BBB) disruption, and pial collateral remodeling at 24 hrs post-pMCAO.
Results
. We found significant neuroprotection in mice exposed to LIFU compared to mock treatment. These findings correlated with a reduced area of IgG deposition in the cerebral cortex, suggesting attenuation of BBB breakdown under LIFU conditions. We also observed increased diameter of CD31-postive microvessels in the ischemic cortex. We observed no significant difference in pial collateral vessel size between FUS and mock treatment at 24 hrs post-pMCAO.
Conclusion
. Our data suggests that therapeutic use of LIFU may induce protection through microvascular remodeling that is not related to its thrombolytic activity.
Prevalence of Different Types of Primary Esophageal Motility Disorders and Their Associated Factors in Patients Referring to Shariati Hospital during 2018-2019
Authors: Assadian Mahan , Momayez Sanat Zahra , Asl Soleimani Hossein , Mikaeli Javad
Published: August 2022

BACKGROUND: Esophageal motility disorders (EMDs) are common in patients with dysphagia and are effectively diagnosed with high-resolution manometry (HREM). In this study, we aimed to evaluate the prevalence of different types of primary EMDs in patients referred for HREM and to further investigate the factors associated with EMDs. METHODS: In this cross-sectional study, all patients referred to the endoscopy section of Shariati Hospital during 2018-2019 (279 patients) were subjected to HREM and were evaluated according to their diagnosis, and the effect of each factor and each symptom on motility disorders was investigated. RESULTS: 84.5% (235) of the participants were diagnosed with at least one esophageal motility disorder; of them, achalasia was the most common form (52.6%). None of the predictive factors showed a statistically significant correlation with EMDs. However, regarding the symptoms, regurgitation and nocturnal cough were significantly more common in patients with EMD (P=0.001 and 0.009, respectively). CONCLUSION: This study demonstrates the high prevalence of EMDs in patients undergoing manometry. None of the factors studied, such as age, sex, diabetes, hypothyroidism, smoking, and alcohol and opium consumption, had a statistically significant correlation with EMDs.
Simultaneous Hepatitis C Virus Genotyping and Variant Detection in Patients with Thalassemia: A Single-Center Phylogenetic Study
Authors: Safarnezhad Tameshkel Fahimeh , Karbalaie Niya Mohammad Hadi , Zamani Farhad , Ajdarkosh Hossein , Khoonsari Mahmoodreza , Faraji Amir Hossein , Motamed Nima , Nikkhah Mehdi , Ameli Mitra , Miri Seyyed Mohammad , Azarkeivan Azita , Sohrabi Masood Reza , Keyvani Hossein
Published: August 2022

BACKGROUND: Hepatitis C virus (HCV) genotype distribution is different in various regions. A variety of strategies could be used to detect HCV genotypes and subtypes. The aim of the present study was to introduce a genotyping method by an in-house protocol that could be used to determine HCV drug-resistant variants and phylogeny studies. METHODS: Samples from 91 patients with thalassemia were used for HCV genotyping by Cobas 4800 platform, and 50 cases of 1a, 1b, and 3a genotypes underwent amplification and sequencing of NS5A and NS5B by using consensus primers via conventional reverse transcription-polymerase chain reaction (RT-PCR) method. An ABI 3730xl system used for direct sequencing. Raw sequences were analyzed by popular bioinformatics software MEGA6 and CLC workbench 5. Phylogenetic construction was drawn using 1000 replicates bootstrap by the neighbor-joining method. Multiple sequence alignment (MSA) was performed for mutation detection. RESULTS: Sequencing results of 50 HCV isolates subtypes 1a (31/45), 3a (15/22) and 1b (4/8) NS5A and NS5B genes showed there were 72 NS5A and 105 NS5B mutations. Moreover, 8 resistant associated substitutions (RASs) were identified in nine thalassemia cases by multiple sequence alignment (MSA) protein analysis. The phylogenetic tree construct drew confirmed by the Cobas HCV genotyping results. CONCLUSION: The phylogenetic analysis could be a useful tool for HCV genotyping in case of determining the drug-resistant substitutions; however, it is time-consuming and needs expert analysis and interpretation. This preliminary study in Iranian patients with thalassemia introduces specific conventional RT-PCR to find RASs to direct acting antivirals (DAAs) and subtype determination at the same time.
Susceptibility of Patients with Inflammatory Bowel Disease to COVID-19 Compared with Their Households
Authors: Anushiravani Amir , Saberzadeh-Ardestani Bahar , Vahedi Homayoon , Fakheri Hafez , Mansour-Ghanaei Fariborz , Maleki Iraj , Nasseri-Moghaddam Siavosh , Vosoghinia Hasan , Ghadir Mohammad Reza , Hormati Ahmad , Kasaeian Amir , Radmard Amir Reza , Khosravi Bardia , Malekzadeh Masoud , Alatab Sudabeh , Sadeghi Anahita , Aminisani Nayyereh , Poustchi Hossein , Sima Ali Reza , Malekzadeh Reza
Published: August 2022

BACKGROUND: Immunosuppressive agents used in the treatment of inflammatory bowel diseases (IBDs) could potentially increase the risk of coronavirus disease 2019 (COVID-19). We aimed to compare COVID-19 frequency in patients with IBD with their households and identify the related risk factors. METHODS: Firstly, a multi-centered, observational study on 2110 patients with IBD and 2110 age-matched household members was conducted to compare COVID-19 frequency. Secondly, the data of patients with IBD and COVID-19 who had called the COVID-19 hotline were added. Multivariable logistic regression was used to evaluate the effect of age, type and severity of IBD, the number of comorbidities, and medications on the frequency of COVID-19 among the patients with IBD. RESULTS: The prevalence of COVID-19 in patients with IBD and household groups was similar (34 [1.61%] versus 35 [1.65%]; P = 0.995). The prevalence of COVID-19 increased from 2.1% to 7.1% in those with three or more comorbidities (P = 0.015) and it was significantly higher in those with severe IBD (P = 0.026). The multivariable analysis only showed a significant association with anti-TNF monotherapy (OR: 2.5, CI: 0.97-6.71, P = 0.05), and other medications were not associated with COVID-19. CONCLUSION: The prevalence of COVID-19 in patients with IBD was similar to the household members. Only patients with IBD receiving anti-TNF monotherapy had a higher risk of COVID-19 susceptibility. This finding could be attributed to the higher exposure to the virus during administration in health care facilities.
Immune Checkpoint Inhibitors Induced Hepatotoxicity; Gastroenterologists’ Perspectives
Authors: Farshidpour Maham , Hutson William
Published: August 2022

BACKGROUND: Immune checkpoint inhibitors (ICIs) have promising clinical activity and are essential medications for patients with several malignancies. However, by deranging the immune system, these novel agents could lead to immune-related adverse events (IRAEs). Hepatotoxicity with checkpoint inhibitors usually results in acute hepatitis or drug-induced liver injury. METHODS: This review article discusses the recent clinical evidence available regarding checkpoint inhibitor-induced hepatitis and reviews an approach to their diagnosis and management. CONCLUSION: ICIs have improved patients’ outcomes with different forms of malignancy; however, ICIs-related liver damage is a clinically significant entity in these patients. All patients should be monitored carefully for IRAEs while undergoing treatment with ICIs.
Rare Presentation of Isolated Spontaneous Bacterial Empyema without Concomitant Ascites in a Patient with Cirrhosis
Authors: Dharmalingam Anbu Krithigha , Pandurangan Viswanathan , Ramadurai Srinivasan , Arthur Preetam , Lakshmanan Suja , Nair Aiswarya M
Published: August 2022

In decompensated cirrhosis, massive ascites and pleural effusion (hepatic hydrothorax) can be complicated by infection, which manifests either as spontaneous bacterial peritonitis (SBP) or spontaneous bacterial empyema (SBE). SBE is a distinct and often underdiagnosed complication having different pathogenesis and treatment strategy when compared with parapneumonic empyema. Hepatic hydrothorax in the absence of ascites is rare in patients with cirrhosis. The occurrence of SBE without SBP or ascites is even more of a rarity in cirrhosis and carries great morbidity and mortality. Here we report a case of an elderly female patient with cirrhosis (Child-Pugh Class B) who had unusual features of isolated right-sided hepatic hydrothorax without clinically evident ascites and was later diagnosed as having SBE based on imaging of the thorax, pleural fluid analysis, and cultures. The patient was initially treated conservatively with antibiotics, and diuretics, and later pigtail insertion and drainage was done.
(f*-Ҩ) QUASI BINORMAL OPERATOR OF ORDER ղ
Authors: Mohammed Alaa Hussein
Published: August 2022

In this paper, we introduce a new class of operators on Hilbert space called (f*-Ҩ) quasi binormal operator of order ղ. We study this operator and give some of its properties.
PREMATURE CHILDREN: RISKS OF NON-CARE OF PREGNANCY. PHYSICAL DEVELOPMENT
Authors: Волосников Д.К. , Москалёва Е.Л.
Published: August 2022

По данным ВОЗ каждый год около 15 млн детей рождается преждевременно это более 10 всех детей, рожденных в странах мира. Каждый год от осложнений, связанных с преждевременными родами, умирают более 1 млн детей. Многие выжившие дети остаются инвалидами на всю жизнь, включая трудности в обучении и проблемы со зрением и слухом. Цель исследования оценить факторы риска, ассоциирующие с преждевременными родами, оценить особенности физическое развитие недоношенных новорожденных на основе международного стандарта INTERGROWTH-21st. Проведена оценка акушерско-гинекологического анамнеза, течение беременности и родов у 56 матерей с преждевременными родами. На основе международного стандарта INTERGROWTH-21st проведена оценка физического развития недоношенных новорожденных на момент родов. Выявлено, что больше половины недоношенных детей родились от повторных беременностей. Отягощенный акушерско-гинекологический анамнез был у 30 женщин. Настоящая беременность протекала на фоне анемии у 27 женщин, 23 во время беременности перенесли острую респираторно-вирусную инфекцию. Отмечен высокий процент 80, оперативных родов. Отставание в росте при рождении выявлено у 14 недоношенных новорожденных, что может свидетельствовать о задержке внутриутробного развития. У 21 детей, масса-ростовые показатели не соответствовали гестационному возрасту.

According to the WHO, every year about 15 million children are born prematurely - this is more than 10 of all children born in countries around the world. Every year, more than 1 million children die from complications associated with preterm delivery. Many surviving children remain disabled for life, including learning difficulties and problems with vision and hearing. The purpose of the study was to assess the risk factors associated with preterm birth, to assess the characteristics of the physical development of preterm infants based on the international standard INTERGROWTH-21st. An assessment was made of the obstetric and gynecological history, the course of pregnancy and childbirth in 56 mothers with premature birth. Based on the international standard INTERGROWTH-21st, an assessment was made of the physical development of premature infants at the time of delivery. It was revealed that more than half of premature babies were born from repeated pregnancies. A burdened obstetric and gynecological history was in 30 of women. The present pregnancy was accompanied by anemia in 27 of women, 23 suffered an acute respiratory viral infection during pregnancy. A high percentage of 80 of operative labor was noted. Growth lag at birth was detected in 14 of premature infants, which may indicate intrauterine growth retardation. In 21 of children, weight and height indicators did not correspond to gestational age.
SECURITY OF VITAMIN D CHILDREN AFTER ONCOLOGICAL DISEASE
Authors: Жуковская Е.В. , Карелин А.Ф. , Крутикова Н.Ю. , Юденкова О.А.
Published: August 2022

Была проведена оценка обеспеченности витамином D детей, перенесших онкологическое заболевание. В ходе исследования определено, что 70 детей, перенесших онкологическое заболевание, имеют дефицит ( 20 нг/мл) витамина D. Также были изучены наиболее критичные возрастные периоды по недостаточности кальцидиола. Проанализировано влияние вида онкологии и его лечения на уровень кальцидиола. Изучение проблемы обеспеченности витамином D детей, перенесших онкологические заболевания, позволит улучшить профилактику данных состояний и их раннюю диагностику с последующим лечением, что позволит значительно улучшить качество жизни данных детей

The article assessed the availability of vitamin D in children with cancer. The study determined that 70 of children who have had cancer have a deficiency (20 ng / ml) of vitamin D. The most critical age periods for calcidiol deficiency were also studied. The influence of the type of oncology and its treatment on the level of calcidiol is analyzed. Studying the problem of vitamin D availability for children who have had cancer, will improve the prevention of these conditions and their early diagnosis with subsequent treatment, which will significantly improve the quality of life of these children
DISORDERS OF MINERAL METABOLISM WITH GAUCHER DISEASE
Authors: Жуковская Е.В.
Published: August 2022

Настоящий обзор литературы посвящен стоматологическому статусу на фоне нарушений минерального обмена у пациентов с такой орфанной патологией, как болезнь Гоше (БГ). Авторы ссылаются на данные отечественных и зарубежных ученых о распространённости и клинических проявлениях системного остеопороза у пациентов во всех возрастных группах, о патогенезе нарушений минерального гомеостаза. Характер поражения верхней и нижней челюстей пациентов с БГ обуславливает повышенный кариесогенный риск, развитие пародонтоза, позднее прорезывание и раннюю потерю зубов обсуждается программа нормализации параметров кальциевого обмена. В заключении авторы подтверждают, что наличие значимых проявлений остеопороза является основанием начала/продолжения заместительной терапии.

This review of the literature is devoted to the problems of dental pathology on the background of mineral metabolism disorders in patients with such an orphan pathology as Gaucher disease (GB). The authors cite data from domestic and foreign scientists on the prevalence and clinical manifestations of systemic osteoporosis in patients in all age groups, on the pathogenesis of disorders of mineral homeostasis. The nature of the lesions of the upper and lower jaws of patients with GB causes an increased cariogenic risk, the development of periodontal disease, late teething and early tooth loss a program for normalizing calcium metabolism is discussed. In conclusion, the authors confirm that the presence of significant manifestations of osteoporosis is the basis for starting / continuing replacement therapy.
HOW TO FIGHT PAIN? (PRACTICAL DEVELOPMENT OF THE QUALITY MANAGEMENT SYSTEM DEPARTMENT OF THE CHELYABINSK REGIONAL CHILDREN'S CLINICAL HOSPITAL TO DRAW UP THE INSTITUTION’S STANDARD)
Authors: Огошков П.А. , Овчинникова С.М.
Published: August 2022

В Челябинской областной детской клинической больнице разработан стандарт, определяющий единый порядок оценки уровня боли с целью своевременного и адекватного обезболивания. Стандарт подробно описывает поведенческие индикаторы острой боли у детей. Приведены различные способы (шкалы) оценки боли в зависимости от возраста пациента, тяжести состояния, остроты боли и др. Оценка боли с помощью данных шкал определяет вид обезболивания, путь и кратность введения анальгетиков. В стандарте четко прописан двухступенчатый алгоритм лечения боли, а также разработаны действия медицинского персонала, направленные на профилактику боли, связанной с проведением медицинских манипуляций. Требования стандарта учреждения распространяются на клинические и параклинические отделения больницы.

In the Chelyabinsk Regional Childrens Clinical Hospital, a standard has been developed that defines a unified procedure for assessing the level of pain in order to ensure timely and adequate pain relief. The standard describes in detail the behavioral indicators of acute pain in children. Various methods (scales) for assessing pain are given, depending on the patients age, severity of the condition, the severity of pain, etc. Pain assessment using these scales determines the type of anesthesia, the route and frequency of administration of analgesics. The standard clearly defines a two-stage algorithm for the treatment of pain, as well as the actions of medical personnel aimed at the prevention of pain associated with medical procedures. The institutions standard requirements apply to the clinical and paraclinical departments of the hospital.
WORK EXPERIENCE OF A SIMULATION TRAINING CABINET IN CHELYABINSK REGIONAL PEDIATRIC CLINICAL HOSPITAL
Authors: Киреева Г.Н. , Огошков П.А. , Овчинникова С.М.
Published: August 2022

В статье рассматривается работа системы симуляционно-тренингового обучения и наставничества на рабочем месте (follow me) ГБУЗ «Челябинская областная детская клиническая больница» как способ повышения уровня практических навыков медицинского персонала при оказании медицинской помощи.

he article discusses the work of the system of simulation training and mentoring in the workplace ("follow me") of SBHCI "Chelyabinsk regional pediatric clinical hospital" as a way to improve the level of practical skills of medical personnel in the provision of medical care.
Age-related resilience as a manifestation of neurovegetative regulation of organism’s functions
Authors: Рубинский А.В. , Чалисова Н.И. , Линькова Н.С. , Марченко В.Н.
Published: August 2022

Концепция жизнеспособности человека создана для поиска новых подходов к повышению благополучия лиц среднего, пожилого и старческого возраста. Жизнеспособность человека основывается на физиологических механизмах поддержания гомеостаза и способности органов и тканей к регенерации. Выявление корреляции факторов окружающей среды и уровня реактивности организма является важным аспектом в оценке жизнеспособности и способствует увеличению продолжительности жизни человека. В основе возрастной жизнеспособности лежат нейрофизиологические механизмы защитных процессов на разных уровнях, включая нейронные сети и эпигенетические механизмы регуляции экспрессии генов, MANF, TIMP-2, адропина, ирисина, CCL 2, CCLR 2, β2 M . Исследование медицинских, психологических, социальных показателей жизнеспособности будет способствовать разработке новых подходов к коррекции возрастной патологии.

The concept of human resilience was created to search for new approaches to improving the well-being of middle-aged, elderly and old people. Resilience is based on the physiological mechanisms of maintaining homeostasis and the ability of organs and tissues to regenerate. Identifying the correlation between environmental factors and the level of reactivity of the body is an important aspect in assessing viability. It contributes to an increase in human life expectancy. Age-related resilience is based on neurophysiological mechanisms of protective processes at different levels, including neural networks and epigenetic mechanisms regulating the expression of MANF, TIMP-2, adropin, irisin, CCL2, CCLR2, β2M genes. The study of medical, psychological, and social indicators of resilience will contribute to the development of new approaches to the correction of age-related pathology.
Thioredoxin in fibroblasts of human dermis in the process of aging
Authors: Гунин А.Г. , Голубцова Н.Н. , Емельянов В.Ю. , Тасакова О.С. , Богданов А.В.
Published: August 2022

Цель работы - исследование содержания тиоредоксина в фибробластах дермы человека от эмбрионального развития и до глубокой старости (от 20 нед беременности до 85 лет), а также определение значения тиоредоксина для возрастных изменений численности фибробластов в дерме человека. Тиоредоксин, ядерный антиген пролиферирующих клеток (PCNA), маркер фибробластов виментин выявляли в срезах кожи непрямым иммуногистохимическим методом. В дерме человека от 20 нед беременности до 85 лет наблюдали увеличение доли фибробластов, имеющих положительную окраску на тиоредоксин. Наиболее выраженное возрастание доли тиоредоксин-положительных фибробластов (более чем в 9 раз) наблюдали в возрастном интервале от рождения до 20 лет по сравнению с внутриутробным периодом. Общее число и доля PCNA-положительных фибробластов в дерме уменьшались возрастом, наиболее значительно - с антенатального периода до 40 лет. Корреляционный анализ показал, что возрастное снижение числа фибробластов и их пролиферативной активности достоверно связано с увеличением содержания процента фибробластов с положительной окраской на тиоредоксин. Результаты позволяют предположить, что тиоредоксин участвует в возрастном уменьшении численности и пролиферации фибробластов в дерме человека.

The aim of this work was to examine the content of thioredoxin in fibroblasts of human dermis from the development until deep aging (from 20 weeks of pregnancy until 85 years old), and defining of a role of thioredoxin in age-dependent changes in the number of fibroblasts in the dermis. Thioredoxin, proliferating cells nuclear antigen (PCNA), marker of fibroblasts vimentin were detected with indirect immunohistochemical technique. Results showed that portion of fibroblasts with positive staining for thioredoxin in the dermis is increased from 20 weeks of pregnancy until 85 years old. Most expressed age related increase in portion of thioredoxin positive dermal fibroblasts (more than 9 times) is present form birth until 20 years as compared to antenatal period. General number and percent of PCNA positive fibroblasts in dermis are decreased with age with more expressed changes until 40 years old. Correlation analysis showed that age dependent decrease in the number of fibroblasts and their proliferative activity is significantly associated with increase in thioredoxin positive fibroblasts in dermis. Results allow to suggest that thioredoxin play a role in age dependent decrease in the number of fibroblasts and their proliferation in human dermis.
THE IMPACT OF INFORMATION ASYMMETRY AND FINANCIALPERFORMANCE ON EARNINGS MANAGEMENT BY USING GOOD CORPORATE GOVERNANCE AS MODERATING VARIABLE
Authors: Tambunan Chandra Leonardo Dapinci , Djajanti Atik , Irawan Heri
Published: August 2022

This study was conducted to determine the effect of information asymmetry and financial performance on earnings management by using Good Corporate Governance (GCG) as a moderating variable. Financial performance in this study was measured by profitability and solvability. The type of data used in this study is quantitative data in the form of data in the form of numbers in the form of financial statements on manufacturing companies. The sample involved in this study comprises of 41 manufacturing companies listed on the Indonesia Stock Exchange (BEI); covering 123 firm-year observations from the fiscal years 2018 to 2020. The research hypotheses were tested using Moderated Regression Analysis. The result of this study found that: 1) asymmetry information had significant positive effect to earnings management; 2) profitability had significant positive effect to earnings management; 3) solvability had no significant negative effect to earnings management; 4) GCG can reduce the positive effect of asymmetry information to earnings management; 5) GCG cannot reduce the positive effect of profitability to earnings management; and 6) GCG cannot strengthen the negative effect of solvability to earnings management.
THE INFLUENCE OF FINANCIAL TARGETS, NATURE OF INDUSTRY, CHANGE OF DIRECTORS AND CEO POLITICIANS ON FRAUDULENT FINANCIAL STATEMENTS
Authors: Budiantoro Harry , Nugroho Cahyo Adi , Santosa Perdana Wahyu , Lapae Kanaya
Published: August 2022

This study aims to examine the influence of financial targets, nature of industry, change of directors and ceo politicians on fraudulent financial statements. This study uses a sample of state-owned companies listed on the Indonesia Stock Exchange (IDX) during the 2016-2020 period. The sampling technique in this study is purposive sampling and can be a sample of 17 companies. This study uses secondary data, namely the company's financial statements obtained from the official website of the Indonesia Stock Exchange (IDX). The analytical method used is multiple linear regression. The results of this study indicate that financial targets have a significant positive effect on financial statements. The nature of the lindustry has a negative effect on the financial statements. Changes that have a negative financial effect on reporting fraud. CEO Politicians have no effect on financial statements.
THE ROLE OF AFFECTIVE AND COGNITIVE RESPONSE IN MEDIATING THE EFFECT OF NEW PRODUCT DESIGN ON THE BEHAVIORAL BRAND LOYALTY OF LE MINERALE DRINKING WATER
Authors: Winarti Adriana , Kirana Domi , Udayana Ida Bagus Nyoman
Published: August 2022

This study aims to determine the effect of Le Minerale's new drinking water product design on consumer response and consumer loyalty. This study includes causal research, namely research that finds and describes a causal relationship between the Le Minerale retailer population. The data collection technique used the observational method by distributing questionnaires. Types and sources of data using primary data, validity and reliability are used to test the questionnaire. After the data is collected, the model test and hypothesis test are carried out. SPSS was used for data analysis. The results of this study, the new product design variable has a significant positive effect on cognitive response. New product design has a significant positive effect on affective response. Cognitive response and affective response have a positive and significant effect on behavioral brand loyalty. New product design has an effect on behavioral brand loyalty through cognitive response. New product design affects behavioral brand loyalty through affective response.
MANAGEMENT INFORMATION SYSTEM DESIGN OF PRODUCTION AND SALES AT PT MANDIRI TEGUH INTI SEJAHTERA
Authors: Kartini Paskalia , Willay Thommy , Supriani Riri
Published: August 2022

The change of a period is marked by the development of technology at that time. The development of technology, especially information technology, is related to the increasingly sophisticated computer technology used throughout the world. This makes the role of computers is very important in all aspects of human life. PT Mandiri Teguh Inti Sejahtera is a company that runs a pile production business. Data processing is still done manually such as on calculation process in determining raw materials for production. Sometimes errors in calculation can lead in to errors in production as well. Technique of analyzing and designing system is Unified Modelling Language (UML), database design uses Microsoft SQL Server 2008 and the application is designed using Microsoft Visual Basic.Net 2010. The results is Information System Design of production and sales, it can help PT Mandiri Teguh Inti Sejahtera to produce more precise and accurate information in data processing and decision making processes that are more effective and efficient.
THE EFFECT OF CAPITAL INTENSITY, INDEPENDENT COMMISSIONERS, AND POLITICAL CONNECTIONS ON TAX AVOIDANCE
Authors: Artiningsih Peni Maharani , Wahyudi Djoko
Published: August 2022

The purpose of this study was to determine the effect of capital intensity, independent commissioners, and political connections on tax avoidance in manufacturing companies listed on the Indonesia Stock Exchange in 2018 - 2020. The independent variables used included capital intensity, independent commissioners, and political connections while the dependent variable is tax avoidance. The population in this study were manufacturing companies listed on the Indonesia Stock Exchange in 2018 - 2020 as many as 175 companies. The sample used in this study were manufacturing companies listed on the Indonesia Stock Exchange in 2018 - 2020. Data collection using purposive sampling method. The data needed in this study was obtained from the annual published financial report data published by the IDX. The data analysis method used to test the hypothesis is multiple linear regression analysis. The results showed that independent commissioners had a significant positive effect on tax avoidance. Meanwhile, capital intensity and political connections have no significant effect on tax avoidance.
THE INFLUENCE OF INTELLECTUAL CAPITAL ON COMPANY VALUE WITH CORPORATE GOVERNANCE AS A MEDIATION VARIABLE
Authors: Mardiana Ana , Tangke Paulus , Virghita Angel Excella
Published: August 2022

The purpose of this study is to investigate the effect of intellectual capital on firm value mediated by corporate governance. The variables used in this study are intellectual capital as an independent variable, company value as the dependent variable, and corporate governance as a mediating variable. The population used is all mining companies listed on the Indonesia Stock Exchange (IDX) with the study period in 2016-2018. The number of samples is 31 companies each year, selected by the purposive sampling method. This study uses documentary data, namely annual reports and financial reports. Path analysis is used to analyze data with the test equipment used, namely the classic assumption test, hypothesis test and sobel test. The method used in data collection is non-participant observation, by making observations, taking notes, and studying the annual reports and financial statements of companies that are published by the IDX. The results of this study indicate that corporate governance is unable to mediate the relationship between intellectual capital and firm value. Where intellectual capital has a significant negative effect on corporate governance, intellectual capital does not have a significant positive effect on firm value, and corporate governance has a significant positive effect on firm value.
CALIDAD DE GRANO Y TORTILLAS DE MAÍCES CRIOLLOS Y SUS RETROCRUZAS
Authors: Vázquez-Carrillo Ma. Griselda , Guzmán-Báez Lorena , Andrés-García José Luis , Márquez-Sánchez Fidel , Castillo-Merino Jorge
Published: August 2022

En esta investigación se determinaron las propiedades físicas y químicas del grano de maíces criollos y sus retrocruzas mejoradas, así como la calidad del nixtamal, masa y tortillas de diez de los maíces más usados en México en este proceso. Se analizaron 40 criollos originales (o) y 70 retrocruzas (r) (BC1F3). En 75 % de las retrocruzas el rendimiento del grano se incrementó en 30 %. Los maíces Tuxpeño Norteño, Pepitilla y Celaya fueron los de mayor producción de grano. El peso hectolítrico se incrementó en 60 % en las retrocruzas y se correlacionó negativamente con el índice de flotación (r = -0.74**) y con la proporción de endospermo harinoso (r = -0.45**). Los maíces criollos tuvieron porcentajes de pedicelo, germen y endospermo harinoso estadísticamente mayores que los de sus retrocruzas. Bolita (r)tuvo el menor porcentaje de pedicelo (0.86%), seguido por los criollos Elotes Occidentales, Blando y Dulcillo (0.92 %); estos mismos (o) y (r) presentaron las menores proporciones de pericarpio (4.3 %). Los maíces con mayor proporción de germen fueron Bolita (12.2%), Zapalote Grande (12.4%), y Dulce 9 (14.4 %; este último fue el de mayor contenido de aceite (7.6%). En la nixtamalización los maíces con mayor índice de flotación fueron los de mayor humedad en el nixtamal (r = 0.42**). La masa del maíz Bolita (r) registró los menores valores de viscosidad máxima (190 UB), viscosidad final (290 UB) y firmeza (293 gf); con Bolita se obtuvieron las mejores tortillas, cuya dureza fue de 303 gf. El mejoramiento genético modificó las características físicas del grano y la calidad de las tortillas.
ÍNDICE Y DENSIDAD ESTOMÁTICA FOLIAR EN PLÁNTULAS DE TRES RAZAS DE AGUACATERO
Authors: Barrientos-Priego Alejandro F. , Borys Michal W. , Trejo Carlos , López-López Luis
Published: August 2022

Se estudió la densidad estomática, densidad de células epidérmicas e índice estomático, en las primeras once hojas maduras de plántulas de aguacatero. Se utilizaron plántulas de las tres razas de aguacatero (Antillana, Guatemalteca y Mexicana). Se encontró que en las primeras hojas (hasta la séptima), las plántulas de la raza Antillana tuvieron menor densidad de estomas, la raza Mexicana mostró la mayor densidad estomática y la raza Guatemalteca fue intermedia. En la hoja 11 se detectó la mayor densidad estomática en las tres razas; la raza Mexicana tuvo 419.3 estomas/mm-2, seguida de la raza Antillana con (360.6 estomas/mm-2) y de la raza Guatemalteca con 305.9 estomas/mm-2. En las primeras hojas la densidad de células epidérmicas fue mayor en la raza Guatemalteca, seguida por las razas Mexicana y Antillana, y a partir de la octava hoja fue similar en las tres razas, con una tendencia a incrementarse. El índice estomático presentó baja variación en las diferentes posiciones en el tallo, pero con diferencias entre las tres razas con el siguiente orden: Mexicana>Antillana>Guatemalteca.
Los reglamentos de la administración y una necesaria redefinición del proceso contencioso administrativo urgente
Authors: Jiménez Vivas Javier Eduardo
Published: August 2022

El proceso contencioso administrativo es un instrumento procesal ordinario para brindar tutela procesal contra las actuaciones de la Administración, así como para efectuar un control jurídico del ejercicio de sus funciones. Su modalidad urgente sirve para ofrecer dicha tutela y realizar tal control respecto de vías de hecho y omisiones de la Administración. Sin embargo, nuestra normatividad no considera los casos en que la actuación constitutiva de vía de hecho se produzca respecto de lo establecido en un reglamento, ni tampoco cuando la conducta que la Administración omita esté prevista en un reglamento. Nos encontramos ante dos casos en los cuales el principio constitucional de control interórganos y el derecho constitucional a una tutela judicial efectiva resultan afectados.
El Decreto Legislativo n.o 1513, norma para afrontar el hacinamiento y la protección de la salud como derecho fundamental de las personas recluidas en los establecimientos penitenciarios del Perú
Authors: Irigoín Cubas José Rosario
Published: August 2022

El presente artículo tiene como finalidad abordar el tema del hacinamiento penitenciario como un problema que afrontan los centros penitenciarios del Perú, el cual trae consigo la afectación del derecho a la salud y otros derechos conexos de los internos, a raíz del estado de emergencia causado por el brote de COVID-19 en el mundo. Asimismo, nos ocupamos del tema del derecho a la salud, específicamente el de las personas privadas de su libertad en los establecimientos penales y el deber del Estado de protegerlos, dada la condición especial en la que se encuentran. Se examinan las acciones legislativas que tomó el Estado para proteger dicho derecho; y dentro de ello se analiza específicamente el Decreto Legislativo n.o 1513, que precisa disposiciones de carácter excepcional para el deshacinamiento de establecimientos penitenciarios por riesgo de contagio del coronavirus, con el objetivo de proteger el derecho a la salud de los internos.
Violencia en el contexto de las nuevas tecnologías de la información: el delito de acoso sexual
Authors: Alcalá Molina Félix Andrés
Published: August 2022

El presente artículo tiene como objetivo describir la violencia en el contexto de las nuevas tecnologías de la información: el delito de acoso sexual. En ese sentido, el internet ha permitido que el hombre desarrolle nuevas facetas y logre comunicarse mediante las redes sociales, esto es una auténtica revolución para la sociedad. Desde que el Gobierno peruano dispuso el aislamiento social obligatorio a causa de la pandemia por la COVID-19, los delincuentes informáticos, los pederastas, los stalkers obtuvieron una gran ventaja para perpetrar acciones criminales. Actualmente la violencia en todas sus modalidades a nivel mundial está considerada como un problema de salud pública, y el ciberacoso se ha mostrado como una nueva forma de violencia psicológica que ocasiona problemas de estrés, humillación, ansiedad, depresión en la población más vulnerable.
¿Qué es conforme a la Constitución?: reflexiones desde la ética y la política kantiana
Authors: Chavez Rabanal Mario Gonzalo
Published: August 2022

En las siguientes líneas se reflexiona sobre la pregunta ¿qué es conforme a la Constitución?, primero desde la relación entre normas jurídicas en el marco de la supremacía constitucional, luego desde la interpretación constitucional considerando el caso emblemático de Marbury vs. Madison, donde se instaura la interpretación de acuerdo con la Constitución y finalmente se analiza lo que es conforme a la Constitución a partir de las reflexiones de la ética y la política kantiana poniendo énfasis en la libertad.
Grupo de empresas Business Group
Authors: Ventura Vega Zaira Grimaldina
Published: August 2022

En este artículo jurídico se analiza el tema denominado grupo de empresas desde un enfoque doctrinario, para posteriormente comentar la problemática jurídico-laboral, esto es, el que se carezca de una regulación legal específica en nuestro ordenamiento jurídico. Con la finalidad de que se comprenda mejor el tema, se presenta jurisprudencia seleccionada respecto a la materia.
Inteligencia artificial para la seguridad jurídica. Superando el problema de la cognoscibilidad del derecho
Authors: Peña Carlos Jhonatan Samuel
Published: August 2022

Las personas tienen la dificultad de conocer, identificar y comprender las disposiciones normativas, las cuales al ser abundantes coexisten con la jurisprudencia zigzagueante, la doctrina, entre otros insumos cognitivos jurídicos. En atención a ello, la presente investigación tiene el propósito de intentar superar el problema de la cognoscibilidad del derecho a través de dos aplicaciones prácticas de inteligencia artificial —sistemas expertos jurídicos informativos y sistemas cognitivos—, a fin de procurar que las personas tengan mejores condiciones de acceso, identificación y comprensión del derecho, y así orientar adecuadamente sus conductas. Este escenario logra configurar una nueva interacción entre la información jurídica y las personas, a efectos de alcanzar una mayor cognoscibilidad del derecho como estado ideal de la seguridad jurídica.