bluuebunny/crossref_metadata_2025 huggingface dataset:
Decisions on Technologies for Emissions Control in Port Areas under Subsidy and Low-Carbon Preferences of Customers
Authors: Zhou Haiying
Published: November 2022

The emission control technologies decisions of port and shipping enterprises under subsidy and customers’ low-carbon preferences are discussed from a supply chain perspective. The game models are established under three game models (port-leader Stackelberg game, ship-leader Stackelberg game, and Nash game). The obtained results show that the impact of subsidy and low-carbon preference on demand in its pricing always is considered by the leader in the port supply chain. The profits and emissions in the Nash game are higher than that in the Stackelberg game. When subsidies and customers’ low-carbon preferences are low, the supply chain’s overall profits of using low sulfur oil are higher than that of using shore power. But the supply chain’s carbon emissions of adopting low sulfur oil are also higher than that of adopting shore power. When subsidies and low-carbon preferences of customers are high, the supply chain’s overall profits of using shore power are higher than that of using low sulfur oil. But the supply chain’s carbon emissions of adopting shore power are also higher than that of adopting low sulfur oil. When subsidy and low-carbon preference of customers are in the appropriate(medial) range, the supply chain would choose shore power to reduce emissions from the perspective of profits, and the whole carbon emissions of using shore power are lower than that of using low sulfur oil, so the regulator(government) and enterprises can achieve a win-win situation. Hence for a regulator who has to balance emission control and enterprises’ profits, implementing moderate subsidy within the appropriate range is the better strategy.
Factors Influencing Turnover Intention among Nurses and Midwives in Ghana
Authors: Boateng Angelina Boatemaa , Opoku Douglas Aninng , Ayisi-Boateng Nana Kwame , Sulemana Alhassan , Mohammed Aliyu , Osarfo Joseph , Hogarh Jonathan N.
Published: November 2022

Background. Nurse turnover intention, defined as a measure of nurses’ desire to leave their positions, is a global public health issue with a grave impact on the healthcare workforce. However, literature on it is limited in sub-Saharan Africa, an at-risk region. This study aimed to determine the predictors of turnover intention among nursing staff at a tertiary hospital in Kumasi, Ghana. Methods. This was an institution-basedcross-sectional study conducted among 226 randomly selected nurses and midwives working at a tertiary healthcare center in Kumasi, Ghana. Data were collected by using a structured questionnaire. Significant predictors of turnover intention were analyzed by using multivariate logistic regression analysis. Adjusted odds ratio (AOR) with a 95% confidence interval (CI) and

p

value <0.05 was used. Results. The prevalence of turnover intention among study participants was 87.2% (197/226). About two-thirds (61.5%, 139/226) of the participants were exposed to a high level of workplace hazards. Management support (AOR = 3.09, 95% CI = 1.09–8.75), salary (AOR = 0.07, 95% CI = 0.01–0.46), inadequate number of staff on duty per shift (AOR = 3.36, 95% CI = 1.08–10.47) and participants’ rank (AOR = 6.81, 95% CI = 1.18–39.16) were significantly associated with turnover intention. Conclusion. Overall, the turnover intention was high. Hence, there is a need for policymakers, health administrators, and nurse managers to implement strategies such as increasing staff strength, providing adequate support, incentives, and other forms of motivation for nurses and midwives to help reduce the rate of turnover intention.
Evaluation of Different Adhesive Resin Removal Methods after Debonding Ceramic Orthodontic Molar Tubes: A Scanning Electron Microscope Study
Authors: Atmaca Zeynep , Ulusoy Mutahhar , Ulusoy Cagri
Published: November 2022

Objectives. To evaluate and compare the impacts, bond strength, residual adhesive, and time invested on the enamel surface after debonding of recently introduced ceramic buccal molar tubes with different systems. Materials and Methods. Ceramic molar tubes were bonded to fifty-four maxillary molar teeth, and a shear bond strength (SBS) test was performed. The adhesive remnant index (ARI) scores were recorded, and the samples were divided into two groups for adhesive removal with low-speed instruments: tungsten carbide bur or diamond-coated micropolisher point. The time to clean the enamel surfaces was also noted down for each tooth. The enamel surfaces were investigated with scanning electron microscope (SEM) after adhesives were cleaned. Shapiro-Wilk’s, Kolmogorov-Smirnov’s, and Student’s independent

t

tests were used for statistical analysis. Results. The mean SBS value of the tested ceramic molar tubes was

9.78
±
1.85

 MPa, and the majority of the samples were scored as ARI 1 and ARI 2. No statistically significant difference between PoGo micropolisher and TCB was found in terms of time values for surface cleaning. The enamel surface characteristics of TCB for adhesive remnant removal resulted in a better enamel surface than the single-step diamond polisher when the samples were investigated by using SEM. Conclusions. Ceramic molar tubes may be an enamel-safe product for patients seeking for fully aesthetic orthodontic treatment, if used in carefully handled clinical conditions. One-step polishing systems utilised with low-speed instruments could be used confidentially for cleaning the resin remnants on enamel after orthodontic treatment.
Cytomegalovirus-Specific T Cells from Third-Party Donors Successfully Treated Refractory Cytomegalovirus Retinitis after Unrelated Umbilical Cord Blood Transplantation
Authors: Li Na , Sun Guangyu , Zhu Lihua , Ding Kang , Liu Huilan , Zhu Xiaoyu , Tang Baolin , Yao Wen , Wan Xiang , Geng Liangquan , Qiang Ping , Song Kaidi , Zheng Changcheng , Sun Zimin , Tong Juan
Published: November 2022

Umbilical cord blood (UCB) transplants (UCBTs) are becoming increasingly common in the treatment of a variety of hematologic and nonhematologic conditions. The T cells from UCB are naïve T cells, which have not yet been exposed to antigens and therefore do not contain T cells with specific immune functions against viruses. Cytomegalovirus (CMV) infections occur in more than 80% of patients after UCBT compared to other types of transplantation. Anti-CMV medications are currently restricted, with ganciclovir, foscarnet, and valganciclovir being the most common in China; however, with limited efficacy and considerable side effects, all these drugs are susceptible to viral resistance. In recent years, cytomegalovirus-specific T cells (CMVST) have advanced the treatment of viral infections in immunodeficient patients. CMVST usually uses the same donor as hematopoietic stem cell transplantation. CMVST should be administered to UCBT patients because of the absence of donors after UCBT. In China, there is no report on the use of CMVST to treat CMV infection after UCBT, and foreign reports are also limited. This paper reported a 20-year-old male patient with acute myeloid leukemia who developed cytomegalovirus retinitis (CMVR) after umbilical cord blood transplantation. After ineffective viral treatment, he was treated with a third-party donor CMVST and was successfully transformed into CMV nucleic acid negative.
A Meta-Analysis of Induced Abortion, Alcohol Consumption, and Smoking Triggering Breast Cancer Risk among Women from Developed and Least Developed Countries
Authors: Islam Md. Akhtarul , Sathi Nusrat Jahan , Abdullah Hossain Mohammad , Tabassum Tarana
Published: November 2022

Background. The most prominent form of cancer in women is breast cancer, and modifiable lifestyle risk factors, including smoking, alcohol consumption, and induced abortion, can all contribute significantly to this disease. Objectives. This study’s primary purpose was to assess the prevalence of breast cancer among women in developed and developing countries and the association between three modifiable hazard factors (induced abortion, smoking behavior, and alcohol use) and breast cancer. Methods. This study performed a systematic literature database review up to September 21, 2021. We employed meta-analytic tools such as the random effects model, forest plot, and subgroup analysis to conduct the research. Additionally, we conducted a sensitivity analysis to assess the influence of outliers. Results. According to the random effects model, smoker women have a higher risk of developing breast cancer from different countries (OR = 1.46; 95% CI: 1.08–1.97). In the case of induced abortion, the pooled estimate (OR = 1.25; 95% CI: 1.01–1.53) indicated a significant link between abortion and breast cancer. Subgroup analysis revealed that smoking substantially influences breast cancer in developing and developed countries. Breast cancer was more common among women who smoked in developed countries than in developing nations. Conclusion. The observed findings give sufficient support for the hypothesis that smoking and abortion have a significant influence on breast cancer in different nations. Health organizations should individually design comprehensive scientific plans to raise awareness about the risks of abortion and smoking in developed and developing countries.
Freeway Traffic Speed Prediction under the Intelligent Driving Environment: A Deep Learning Approach
Authors: Hua Chengying , Fan Wei (David)
Published: November 2022

The intelligent transportation system (ITS) has been proven capable of effectively addressing traffic congestion issues. For vehicles to perform effectively and improve mobility under the intelligent driving environment, real-time prediction of traffic speed is undoubtedly essential. Considering the complex spatiotemporal dependency inherent in traffic data, conventional prediction models encounter many limitations. To improve the prediction performance and investigate the temporal features, this study focuses on emerging deep neural networks (DNNs) using the Caltrans Performance Measurement System (PeMS) data. This research also establishes an intelligent driving environment in the simulation and compares the traditional car-following model with deep learning methods in terms of multiple performance metrics. The results indicate that both supervised learning and unsupervised learning are superior to the simulation-based model on the freeway, and the two deep learning networks are almost identical to one another. Besides, the result reveals that all models have their latent features for different time dimensions under the low traffic loads, transition states, and heavy traffic loads. This is critical in the application of prediction technologies in ITS. The findings can assist transportation researchers and traffic engineers in both traffic operation and management, such as bottleneck identification, platooning control, and route planning.
Discovering Approximate and Significant High‐Utility Patterns from Transactional Datasets
Authors: Tang Huijun , Wang Le , Liu Yangguang , Qian Jiangbo
Published: November 2022

Mining high‐utility pattern (HUP) on transactional datasets has been widely discussed, and various algorithms have been introduced to settle this problem. However, the time‐space efficiency of the algorithms is still limited, and the mining system cannot provide timely feedback on relevant information. In addition, when mining HUP from taxonomy transactional datasets, a large portion of the quantitative results are just accidental responses to the user‐defined utility constraints, and they may have no statistical significance. To address these two problems, we propose two corresponding approaches named Sampling HUP‐Miner and Significant HUP‐Miner. Sampling HUP‐Miner pursues a sample size of a transitional dataset based on a theoretical guarantee; the mining results based on such a sample size can be an effective approximation to the results on the whole datasets. Significant HUP‐Miner proposes the concept of testable support, and significant HUPs could be drawn timely based on the constraint of testable support. Experiments show that the designed two algorithms can discover approximate and significant HUPs smoothly and perform well according to the runtime, pattern numbers, memory usage, and average utility.
Predictive Value of Arterial Blood Lactic Acid Concentration on the Risk of in-Hospital All-Cause Death in Patients with Acute Heart Failure
Authors: Hu Weiwei , Yuan Lei , Wang Xiaotong , Zang Baohe , Zhang Yang , Yan Xianliang , Zhao Wenjing , Chao Yali
Published: November 2022

The study aims to examine the predictive value of arterial blood lactic acid concentration for in-hospital all-cause mortality in the intensive care unit (ICU) for patients with acute heart failure (AHF). We retrospectively analyzed the clinical data of 7558 AHF patients in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The exposure variable of the present study was arterial blood lactic acid concentration and the outcome variable was in-hospital all-cause death. The patients were divided into those who survived (n = 6792) and those who died (n = 766). The multivariate logistic regression model, restricted cubic spline (RCS) plot, and subgroup analysis were used to evaluate the association between lactic acid and in-hospital all-cause mortality. In addition, receiver operating curve (ROC) analysis also was performed. Finally, we further explore the association between NT-proBNP and lactic acid and in-hospital all-cause mortality. Compared with the lowest quartiles, the odds ratios with 95% confidence intervals for in-hospital all-cause mortality across the quartiles were 1.46 (1.07–2.00), 1.48 (1.09–2.00), and 2.36 (1.73–3.22) for lactic acid, and in-hospital all-cause mortality was gradually increased with lactic acid levels increasing (

P

for trend <0.05). The RCS plot revealed a positive and linear connection between lactic acid and in-hospital all-cause mortality. A combination of lactic acid concentration and the Simplified Acute Physiology Score (SAPS) II may improve the predictive value of in-hospital all-cause mortality in patients with AHF (AUC = 0.696). Among subgroups, respiratory failure interacted with an association between lactic acid and in-hospital all-cause mortality (

P

for interaction <0.05). The correlation heatmap revealed that NT-proBNP was positively correlated with lactic acid (r = 0.07) and positively correlated with in-hospital all-cause mortality (r = 0.18). There was an inverse L-shaped curve relationship between NT-proBNP and in-hospital all-cause mortality, respectively. Mediation analysis suggested that a positive relationship between lactic acid and in-hospital all-cause death was mediated by NT-proBNP. For AHF patients in the ICU, the arterial blood lactic acid concentration during hospitalization was a significant independent predictor of in-hospital all-cause mortality. The combination of lactic acid and SAPS II can improve the predictive value of the risk of in-hospital all-cause mortality in patients with AHF.
Phenolics, Antioxidant and Antibacterial Activities of Immature and Mature Blumea balsamifera Leaf Extracts Eluted with Different Solvents
Authors: Jirakitticharoen Sirinapha , Wisuitiprot Wudtichai , Jitareerat Pongphen , Wongs-Aree Chalermchai
Published: November 2022

Blumea balsamifera (L.) DC., belonging to the Asteraceae family, also known as “ngai camphor,” is one of the traditional herbs used in Thailand for folk medicine and a component in local food and drinks. There was, however, no evidence indicating the presence of beneficial compounds at different leaf ages. Exploring various extraction solvents, we investigated the phenolics, flavonoids in particular quercetin content, antioxidant capacity, and antibacterial activity of immature and mature leaf extracts. The dried leaves were macerated in 50% ethanol, 95% ethanol, hexane, or decocted in water. Bioactive substances were analyzed by UV spectrophotometry and HPLC. Analysis of antioxidant capacity was done byDPPH, ABTS, FRAP, and NO scavenging assays. The antibacterial activity of immature leaf extract eluted with 50% ethanol was subsequentially evaluated in vitro. Extraction with 50% ethanol proved optimal, yielding 1.2–1.6-fold and 1.5-fold greater immature and mature leaf extracts than other solvents. More phenolics (1.2-fold), flavonoids (1.1-fold), quercetin content (4.8-fold), and antioxidant activity (1.3-fold) were found in the immature leaf extract. There was a significant positive correlation between antioxidant activity and bioactive compounds. The immature leaf extract eluted with 50% ethanol showed antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration of 0.5 mg/mL. The immature leaves of B. balsamifera are a rich source of quercetin and phenolics, and 50% ethanol proved optimal for extracting bioactive components from these leaves.
Suppression of T-Cell Proliferation by Normal Density Granulocytes Led to CD183 Downregulation and Cytokine Inhibition in T-Cells
Authors: Westerlund Julia , Askman Sandra , Pettersson Åsa , Hellmark Thomas , Johansson Åsa C. M. , Hansson Markus
Published: November 2022

Normal density granulocytes (NDGs) can suppress T-cell responses in a similar way as myeloid-derived suppressor cells (MDSCs). In this study, we tested the hypothesis that NDGs from healthy donors preferentially inhibit T helper 1 (Th1) cells and investigated the myeloid-derived suppressive effect in different T-cell populations. We found that NDG-induced suppression of T-cell proliferation was contact dependent, mediated by integrin CD11b, and dependent on NDG-production of reactive oxygen species (ROS). The suppression was rapid and occurred within the first few hours of coculture. The suppression did not influence the CD8+/CD4+ ratio indicating an equal sensitivity in these populations. We further analyzed the CD4+ T helper subsets and found that NDGs induced a loss of Th1 surface marker, CD183, that was unrelated to ligand-binding to CD183. In addition, we analyzed the Th1, Th2, and Th17 cytokine production and found that all cytokine groups were suppressed when T-cells were incubated with NDGs. We therefore concluded that NDGs do not preferentially suppress Th1-cells. Instead, NDGs generally suppress Th cells and cytotoxic T-cells but specifically downregulate the Th1 marker CD183.
Mechanisms of NO-Mediated Protein S-Nitrosylation in the Lens-Induced Myopia
Authors: Lu Ying , Song Weitao , Li Yuanjun , Xiao Jingge , Du Kaixuan , Fu Qiuman , Zhang Yanni , Zhao Liting , Yin Yewei , Hu Tu , Wen Dan
Published: November 2022

Background. Myopia is a chronic ocular disease, emerging as the most common type of refractive error. This study intends to preliminarily explore the roles of protein S-nitrosylation of nitric oxide (NO) in the regulation of myopia by detecting the expression of neuronal nitric oxide synthase (nNOS) and downstream S-nitrosylation, using the animal model of lens-induced myopia (LIM) in mice. Methods. The 3-week-old C57BL/6 J mice were divided into three groups: group I, lens-induced 0-week group (take eyeballs at the age of 3 weeks); group II, self-control eyes of experimental group (take eyeballs at the age of 7 weeks); and group III, lens-induced 4-week group (take eyeballs at the age of 7 weeks). The diopter and axial length of each group were measured by streak retinoscopes and optical coherence tomography (OCT) before and after model establishment. The protein expressions and locations of nNOS and S-nitrosylated proteins (PSNOs) were measured by western blot and immunofluorescence staining. Site-specific proteomic for protein S-nitrolysation was used to detect the existence and location of S-nitrosylation proteins in the retina of myopic and nonmyopic mice. The Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and motif enrichment analyses were performed. The differential sites were analyzed by GO, KEGG, and motif. Irreversible biotinylation procedure combined with protein purification and western blot was used to detect the protein expression of α-enolase (ENO1), a key player in the hypoxia-related signal pathway. Results. The expressions of nNOS and PSNOs were significantly lower in the retina of experimental eyes than that in self-control eyes and 3-week-old baseline group. A total of 595 S-nitrosylated proteins, 709 S-nitrosylated peptides, and 708 S-nitrosylated sites were identified by site-specific S-nitrolysation proteomics in the retina of myopic and control eyes. A total of 19 differentiation loci were screened, of which 13 sites were downregulated and 6 sites were upregulated in experimental eyes compared with the self-control group. Specifically, the expression of SNO-ENO1 was significantly lower in the retina of experimental eyes than that in self-control eyes and 3-week-old baseline group. Conclusion. LIM induces the decrease of nNOS and PSNO protein levels in the retina of myopic mice. NO-mediated nonclassical protein S-nitrosylation modification may play an important role in the regulation of lens-induced myopia. ENO1 may be a key factor in the regulation of S-nitrosylation modification of myopia.
Max‐EWMA Chart Using Beta and Unit Nadarajah and Haghighi Distributions
Authors: Akram Muhammad Farhan , Ali Sajid , Shah Ismail , Muslim Raza Syed Muhammad
Published: November 2022

The recent industrial revolution is a result of modern technological advancement and industrial improvements require quick detection of assignable causes in a process. This study presents a monitoring scheme for unit interval data assuming beta and unit Nadarajah and Haghighi distributions. To this end, a maximum exponentially weighted moving average (Max‐EWMA) chart is introduced to jointly monitor unit interval bounded time and magnitude data. The performance of the proposed chart is evaluated by using average run length and other characteristics of run length distribution using extensive Monte Carlo simulations. Besides a comprehensive simulation study, a real data set is also used to assess the performance of the chart. The results supplementing the proposed chart are efficient for joint monitoring time and magnitude, and simultaneous shifts are detected more quickly than separate shifts in the process parameters.
[Retracted] Phyto‐Extract‐Mediated Synthesis of Silver Nanoparticles (AgNPs) and Their Biological Activities
Authors: Adnan Muhammad , Akbar Asma , Mussarat Sakina , Murad Waheed , Hameed Ishfaq , Begum Shaheen , Nazir Ruqia , Ali Nawab , Ali Essam A. , Bari Ahmed , Aziz Muhammad Abdul , Khan Shahid Niaz
Published: November 2022

Background. Nanotechnology finds broad applications in the field of nanomedicine, an emerging new field used for diagnosis, treatment, prevention of diseases, and improvement of health. Objectives. To synthesize silver nanoparticles (AgNPs) from Withania somnifera and Fagonia indica and to carry out their antimicrobial, insecticidal, and phytotoxic activities, a step toward the new range of nanomedicines. Methods. Silver nanoparticles were synthesized from Withania somnifera and Fagonia indica by chemical reduction method, and further biological activities of these nanoparticles were compared with crude methanolic extract, prepared through cold maceration process, at the concentration of 50 mg/ml. Results. Among all tested bacterial pathogens, crude extract of W. somnifera showed a statistically high significant inhibition zone in millimeter against Pseudomonas aeruginosa (21; p < 0.01). AgNPs showed highly significant result against Streptococcus pneumonia (14; p < 0.01). In comparison with crude extracts, AgNPs showed statistically significant (p < 0.01) results against S. pneumonia (AgNPs, 14; crude, 8.33 mm). Crude extract showed significant inhibition zone against two bacterial strains, P. aeruginosa (crude, 21; AgNPs, 11.67 mm) and Klebsiella pneumoniae (crude, 11.33; AgNPs, 8 mm). Crude extracts of F. indica showed the significant activity against Vibrio cholera (p < 0.01; 11.33 mm). Silver nanoparticles of F. indica exhibited the highest significant activity against Aspergillus flavus and Fusarium oxysporum while AgNPs of W. somnifera were active only against A. flavus. Extracts of W. somnifera and F. indica showed increasing phytotoxic activity with increasing concentrations. The highest significant inhibition was obtained for crude extract (46.7) and AgNPs (45.7) of F. indica at 1000 μg/ml. Insecticidal activity of crude and AgNPs of both plants showed significant inhibition against all tested insects with increasing time intervals, and the highest significant result was obtained at 72 hours with a value of p < 0.01 except T. castaneum. Conclusions. Both crude and AgNPs showed potent activity; however, in comparison, silver nanoparticles showed slightly enhanced activity. Crude and AgNPs of both plants showed good phytotoxic and insecticidal inhibition. Antimicrobial studies of AgNPs on diseases causing pathogens open a door for new antimicrobial agents and could be the answer to antibiotic resistance after further analysis.
Postoperative Mortality Rate after Radical Cystectomy: A Systematic Review of Epidemiologic Series
Authors: Korkes Fernando , Timoteo Frederico , Baccaglini Willy , Glina Felipe , Faba Oscar Rodriguez , Palou Redorta Juan , Glina Sidney
Published: November 2022

Introduction: Mortality after radical cystectomy (RC) varies widely in the literature. In cohort studies, mortality rates can vary from as low as 0.5% in large-volume academic centers (2) to as high as 25% in developing countries series. This study aims to perform a systematic review of population-based studies reporting mortality after RC. Methods: A Systematic search was performed in Medline (PubMed®), Embase, and Cochrane for epidemiologic studies reporting mortality after RC. Institutional cohorts and those reporting mortality for specific groups within populations were excluded. Case series and non-epidemiologic series were also excluded. The aim of this review is to evaluate in-hospital mortality (IHM), 30-day mortality (30M), and 90-day mortality (90M). Results: Systematic search resulted in 42 papers comprising 449,661 patients who underwent RC from 1984 to 2017. Mean age was 66.1. Overall IHM, 30M, and 90M were 2.6%, 2.7%, and 4.9%, respectively, with 90M being 2.6 times higher than IHM on average. Lowest IHM was found in Canada and Australia (0.2% and 0.6%, respectively), while the highest IHM was 7.8% (Brazil). Canada and Spain showed the highest 90M (6.5%). 159,584 urinary diversions were analyzed, being mostly ileal conduits (76.8%). Conclusions: The majority of the studies available are from major developed economies with paucity of data in the developing world. 90M after RC tends to be at least twice as high as IHM. The knowledge of such epidemiologic data is vital to guide public policies, such as centralization, in order to reduce mortality.
LncRNA DDX11-AS1 Promotes Chemoresistance through LIN28A-Mediated ATG12 mRNA Stabilization in Breast Cancer
Authors: Si Xinxin , Zhang Gongming , Li Mingyuan , Yao Mingli , Shi Xiao , Dong Zibo , Gao Song
Published: November 2022

Introduction: During breast cancer chemotherapy, the chemoresistance that frequently accompanies the treatment has become a big challenge. Long noncoding RNAs (LncRNAs) have been related to the development of chemoresistance in multiple cancer types. LncRNA DDX11-AS1 has shown a carcinogenic role in lung and colorectal cancer and was reported to enhance oxaliplatin resistance in gastric cancer and Taxol insensitivity in esophageal cancer. But its role in breast cancer chemotherapy drug resistance remains unknown. This study aimed to investigate the function and mechanism of lncRNA DDX11-AS1 in breast cancer chemoresistance. Methods: The relationship between DDX11-AS1 and adriamycin (ADR) resistance was confirmed by qPCR, cell viability tests, and survival analysis. Then, RNA immunoprecipitation was conducted to evaluate the interaction between DDX11-AS1 and RNA-binding protein LIN28A. The regulation effect of LIN28A on autophagy-related genes ATG7 or ATG12 was detected by RNA stability assay and Western blot. Their correlation analysis was evaluated in GEO datasets and further validated by immunohistochemical results. The clinical significance of DDX11-AS1, ATG7, or ATG12 was evaluated by Kaplan-Meier Plotter analysis. Results: Here, we reported DDX11-AS1 was significantly upregulated in chemoresistant breast cancer cells and overexpression of DDX11-AS1 promoted ADR resistance in breast cancer. LIN28A could interact with DDX11-AS1 and was involved in DDX11-AS1-mediated ADR resistance. Interfering with LIN28A reversed DDX11-AS1-induced ADR resistance. LIN28A could increase the protein level of ATG7 and ATG12 by increasing their mRNA stability. Survival analysis showed that ATG12 expression level was negatively correlated with the prognosis of breast cancer patients. Conclusion: This study clarifies the role of DDX11-AS1 in breast cancer chemoresistance and revealed a new mechanism, that is, interacting with LIN28A to stabilize ATG7 and ATG12 and jointly promote chemorefractory. These findings warrant further in vivo investigations to study DDX11-AS1 as a potential target to overcome chemoresistance.
Retained Presumed Intraocular Cotton Fiber after Implantable Collemer Lens Implantation: A Case Report
Authors: AlNaim Abdulrahman , AlArfaj Motazz , Al Rashidi Shaker , Al Zaid Salem , AlSarhani Abdulaziz
Published: November 2022

Retained intraocular foreign body is a known complication of ophthalmic surgery. The presence of intraocular cotton fibers after ophthalmic surgery is well-documented in different procedures including cataract and vitreoretinal surgeries. This report describes a case of retained cotton fiber after implantable collamer lens (ICL) implantation. This report describes a case of a 23-year-old female who was diagnosed with high myopia and mild astigmatism. The patient was selected to undergo ICL implantation in her right eye. The postoperative examination was done a few hours after the procedure, and a cotton fiber was incidentally found to be attached to the posterior surface of the ICL without causing visual disturbances or any other abnormal findings. This patient was followed up closely within the 2 postoperative weeks, and a 1-year follow-up did not reveal any change in the cotton fiber place or position, nor was there any other complication. In conclusion, cotton fibers are typically inert and usually do not lead to major complications. The decision of whether to surgically remove these fibers or not should only be made after weighing the benefits against the risks of such intervention. Recurrent inflammatory reactions or iridocyclitis related to the presence of cotton fibers could validate surgical intervention; however, the presence of cotton fibers solely does not necessitate early surgical removal.
The Association of HLA Alleles and Haplotypes with Age of Disease Onset in Pakistani Psoriatic Patients
Authors: Munir Saeeda , Rahman Simeen Ber , Rehman Sadia , Saba Nusrat , Mazhar Kehkashan , Naluai Åsa Torinsson
Published: November 2022

Introduction: The human leukocyte antigen (HLA) region on chromosome 6p21 is well known to carry the most important genetic factors in susceptibility to psoriasis. Different HLA alleles and haplotypes have been reported to be associated with psoriasis in different populations. Psoriasis has a variable age of onset and, based on this, it can be classified into two types; type I with age of onset before 40 years of age and type II with age of onset after 40 years of age. The objective of this study was to determine the association of HLA class I and class II alleles and haplotypes with disease and stratification using age of onset in Pakistani psoriatic patients. Methods: A group of 603 individuals (326 cases and 277 controls) were analyzed for HLA class I and II alleles and haplotype association by sequence specific PCR. The association was further analyzed according to the age of onset of the patients. Results: We found that HLA alleles B*57 and Cw*06:02, DQB1*03:03:02 are strongly associated with early onset psoriasis, while alleles B*15, DRB1*13:02 and DQB1*03:03:02 are associated with late-onset psoriasis. Cw*06:02 allele was not associated with late-onset psoriasis patients. Allele DQB1*03:03:02 had the highest odds ratio in all patients. We found a novel association specifically with late-onset psoriasis samples with the haplotype HLA-A*11; B*15; Cw*04; DRB1*15; DQB1*05 (Pc = 3.60 × 10−7). We also found strong association with previously reported extended haplotype EH-57.1: HLA-B*57; Cw*06:02; DRB1*07:01; DQB1*03:03:02 in all our patients (Pc = 8.34 × 10−07). Conclusion: Our results show that different HLA class I and II alleles and haplotypes are associated with psoriasis at different age of onset. In this study, we have reported novel alleles and haplotype association with late-onset psoriasis. Our data confirm the previous strong associations with HLA alleles and haplotypes and also reports novel alleles and haplotype association in Pakistani psoriasis patients.
Do Not Attempt Resuscitation Order Rates in Hospitalized Patients With Heart Failure, Acute Myocardial Infarction, Chronic Obstructive Pulmonary Disease, and Pneumonia
Authors: Shore Supriya , O'Leary Michael , Kamdar Neil , Harrod Molly , Silveira Maria J. , Hummel Scott L. , Nallamothu Brahmajee K.
Published: November 2022

Background

Descriptions of do not attempt resuscitation (DNAR) orders in heart failure (HF) are limited. We describe use of DNAR orders in HF hospitalizations relative to other common conditions, focusing on race.

Methods and Results

This was a retrospective study of all adult hospitalizations for HF, acute myocardial infarction (AMI), chronic obstructive pulmonary disease (COPD), and pneumonia from 2010 to 2016 using the California State Inpatient Dataset. Using a hierarchical multivariable logistic regression model with random effects for the hospital, we identified factors associated with DNAR orders for each condition. For racial variation, hospitals were divided into quintiles based on proportion of Black patients cared for. Our cohort comprised 399 816 HF, 190 802 AMI, 192 640 COPD, and 269 262 pneumonia hospitalizations. DNAR orders were most prevalent in HF (11.9%), followed by pneumonia (11.1%), COPD (7.9%), and AMI (7.1%). Prevalence of DNAR orders did not change from 2010 to 2016 for each condition. For all conditions, DNAR orders were more common in elderly people, women, and White people with significant site‐level variation across 472 hospitals. For HF and COPD, hospitalizations at sites that cared for a higher proportion of Black patients were less likely associated with DNAR orders. For AMI and pneumonia, conditions such as dementia and malignancy were strongly associated with DNAR orders.

Conclusions

DNAR orders were present in 12% of HF hospitalizations, similar to pneumonia but higher than AMI and COPD. For HF, we noted significant variability across sites when stratified by proportion of Black patients cared for, suggesting geographic and racial differences in end‐of‐life care.
Device‐Based Approaches Targeting Cardioprotection in Myocardial Infarction: The Expanding Armamentarium of Innovative Strategies
Authors: Romeo Francisco José , Mazurek Renata , Sakata Tomoki , Mavropoulos Spyros A. , Ishikawa Kiyotake
Published: November 2022

Coronary reperfusion therapy has played a pivotal role for reducing mortality and heart failure after acute myocardial infarction. Although several adjunctive approaches have been studied for reducing infarct size further, both ischemia–reperfusion injury and microvascular obstruction are still major contributors to both early and late clinical events after acute myocardial infarction. The progress in the field of cardioprotection has found several promising proof‐of‐concept preclinical studies. However, translation from bench to bedside has not been very successful. This comprehensive review discusses the importance of infarct size as a driver of clinical outcomes post‐acute myocardial infarction and summarizes recent novel device‐based approaches for infarct size reduction. Device‐based interventions including mechanical cardiac unloading, myocardial cooling, coronary sinus interventions, supersaturated oxygen therapy, and vagal stimulation are discussed. Many of these approaches can modify ischemic myocardial biology before reperfusion and offer unique opportunities to target ischemia–reperfusion injury.
Trustworthy Government: The Obligations of Government & the Responsibilities of the Governed
Authors: Levi Margaret
Published: November 2022

Establishing trustworthy government is a major problem for contemporary democracies. Without public confidence, government faces considerable noncompliance with its policies, as has been the case with the reaction of some subpopulations to COVID safety requirements. The pressures on government today are numerous. The challenges are complex and the polity diverse. Creating confidence and thus willing compliance requires a demonstrated government competence. It also requires political leadership committed to the collective good and to forging a common identity among multiple subgroups while recognizing their distinctive differences and needs. Citizens are also crucial actors. It is incumbent upon a democratic citizenry that it recognizes its responsibilities to and interdependence with others in the polity as members of an expanded community of fate.
On General Terms for Texts in Early China
Authors: Fahr Paul
Published: November 2022

This article explores the lexical field of “text” in early China. It argues that words pertaining to it should not be understood as referring to textual genres, but as conveying an abstract notion of “(written) text.” In particular, it treats the word shi 事 in Liu Xiang’s 劉向 (79–8 BCE) editorial reports as well as yu 語 in many different early sources. Especially the second term has been understood as denoting a certain textual genre. This is incorrect as can be shown by analyzing occurrences of this word in relevant contexts. Rather, yu first referred to short proverbs and later, by way of semantic derivation, came to acquire the meaning “text” in general. This meaning also applies to the word’s usage in designations of early compilations such as Lunyu. Accordingly, the latter title should simply be understood as “compiled texts.”
Magdalene Response
Authors: Walsh Richard
Published: November 2022

This response essay responds to the articles on Mary Magdalene in film by James Crossley, Matthew Rindge, Meredith J. C. Warren, and Rhonda Burnette-Bletsch.
Knowledge is Power: Politics and Formal Education in the Sixteenth-Century Kongo Kingdom
Authors: Brinkman Inge
Published: November 2022

This paper takes us to the beginning of the sixteenth century in the West Central African kingdom of Kongo, some years after Portuguese navigators first established contact with the Kongo royal elite. A formal school system was introduced with the support of the Kongo king Afonso I – who ruled from 1509 to 1542 – as he used the Christian school system to integrate the districts of the kingdom more fully into political unity. Apart from this centralising tendency, there was at the same time a process to establish contacts abroad. Quite a few young Kongo men of noble birth were sent to schools at convents in Portugal to be trained as church staff, interpreters or ambassadors of the Kongo kingdom.

These two tendencies – internally oriented centralisation and externally oriented internationalisation – will be discussed in the light of the developments of the school system in the Kongo kingdom in the sixteenth century and beyond. This will lead to an interpretation of the Kongo school system in terms of global integration and local appropriation.
Women, Military, and State: Indonesian Women’s Military Representation During the Early Independence Period
Authors: Salebaran Salebaran , Amini Mutiah
Published: November 2022

This article looks at the role of women in the Indonesian military in the second half of the twentieth century, specifically from Indonesia’s independence on 17 August 1945 until the 1960s. Following state efforts to create uniformity among citizens by including women in all sectors of national life, including the military – long perceived to be a masculine institution – Indonesian women only became active in the military after men. Women’s early military participation was critical in advancing their role in the public sphere and in eroding men’s military dominance. The purpose of this analysis is to investigate the role of the state in providing space for women in the armed forces. It uncovers how early policies in Indonesia excluded women from military forces and activities; the first women’s corps was established only fifteen years after Indonesia declared independence. Even then, they were confined to the female-only corps to allow the Indonesian military to maintain its masculine image.
Hybrid Nanofluid Heat and Mass Transfer Characteristics Over a Stretching/Shrinking Sheet with Slip Effects
Authors: Reddy P. Sudarsana , Sreedevi P. , Chamkha Ali J.
Published: November 2022

Unsteady magneto-hydrodynamic heat and mass transfer analysis of hybrid nanoliquid flow over stretching/shrinking surface with chemical reaction, suction, slip effects and thermal radiation is analyzed in this problem. Combination of Alumina (Al2O3) and Titanium
Oxide (TiO2) nanoparticles are taken as hybrid nanoparticles and base fluid is taken as water. Using similarity transformation method the governing equations are changed in to set of ordinary differential equations. These resultant equations are numerically evaluated by utilizing
Finite element method. The influence of several pertinent parameters on fluids temperature, concentration and velocity is calculated and the outcomes are plotted through graphs. The values of non-dimensional rates of heat transfer, mass transfer and velocity are also analyzed and the outcomes
are represented in tables. Temperature sketches of hybrid nanoliquid intensified in both unsteady and steady cases as volume fraction of both nanoparticles rises.
Simulation of Nonlinear Viscous Fingering in a Reactive Flow Displacement: A Multifractal Approach
Authors: Shahnazari M. R. , Saberi A. , Chamkha Ali J.
Published: November 2022

fractal analysis of viscous fingering of a reactive miscible flow displacement in homogeneous porous media is investigated and multifractal spectrum, and fractal dimension are introduced as two essential features to characterize the irregularity of finger patterns. The Reaction of the
two reactant fluids generates a miscible chemical product C in the contact zone. Considering the similarity between chemical products and coastline, monofractal and multifractal analyzes are performed. In monofractal analysis, the box-counting method is implemented on binary images and in
multifractal analysis, due to the image processing; the fractal characteristics of viscous fingering instability are analyzed by means of fractal quantities such as Holder exponent, multifractal spectrum, f (α)-image and fractal dimension dynamics. Fractal analysis shows
that the fractal dimension increases with time. Also, by considering five different nonlinear simulations, the results show that in the case both sides of the chemical product C are unstable, the multifractal spectrum curve has the highest peak, which means the more complex finger patterns
lead to more values of fractal dimension. In addition, a comparison between different values of Ar is conducted and the results show similar behavior. However, small value of aspect ratio leads to a broader width of the multifractal spectrum curve. Furthermore, f (α)-images
of concentration contour were investigated for different precisions and some undetectable finger patterns were observed in these images. It can be concluded that the use of f (α)-image represents more detailed image than concentration contours.
Accurate Attribution and Seasonal Prediction of Climatic Anomalies Using Causal Inference Theory
Authors: He Shan , Yang Song , Chen Dake
Published: November 2022

Using features based on correlation or noncausal dependence metrics can lead to false conclusions. However, recent research has shown that applying causal inference theory in conjunction with Bayesian networks to large-sample-size data can accurately attribute synoptic anomalies. Focusing on the East Asian summer monsoon (EASM), this study adopts a causal inference approach with model averaging to investigate causation of interannual climate variability. We attribute the EASM variability to five winter climate phenomena; our result shows that the eastern Pacific El Niño–Southern Oscillation has the largest causal effect. We also show that the causal precursors of the EASM variability are interpretable in terms of physics. Using linear regression, these precursors can predict the EASM one season ahead, outperforming correlation-based empirical models and three climate models. This study shows that even without large-sample-size data and substantial human intervention, even laymen can implement the causal inference approach to investigate the causes of climatic anomalies and construct reliable empirical models for prediction.

Significance Statement

We use causal inference theory to redesign the attribution procedure fundamentally and adjust a causal inference approach to commonly used climate research data. Our study shows that the causal inference approach can exhaustively reveal the causes of climatic anomalies with little human intervention, which is impossible for correlation-based studies. According to this attribution, one can construct models with a better predictive performance than the climate and correlation-based empirical models. Therefore, our causal inference approach will tremendously help both meteorologists and laymen (e.g., stakeholders and policymakers) accurately predict climate phenomena and reveal their interpretable causes. We recommend that it become a standard practice in attribution studies and operational prediction.