bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Effectiveness of Outdoor Fitness Equipment Intervention in Achieving Fitness Goals for Seniors
Authors: Chow Hsueh-Wen , Chang Kun-Tang , Fang I-Yao
Published: November 2021

Despite the popularity of outdoor fitness equipment (OFE) in public spaces with the aim of increasing physical activity (PA), very little research has been conducted to investigate the effectiveness of the equipment’s use, especially for achieving the target fitness goal. This study designed an OFE training protocol incorporating four modalities of PA: endurance (air walker and ski machine), resistance (rowing machine and bonny rider), flexibility (arm stretch and shoulder wheel), and balance exercise (waist twister). Seniors who completed the protocol demonstrated that for endurance training, participants were at moderate intensity from heart rate and perceived exertion, while significantly improving cardiac endurance in the two min step test. For resistance/flexibility/balance interventions, only the handgrip strength test, the 30 s chair stand test, the right-hand shoulder flexion test, the right-hand shoulder horizontal abduction test, the single-leg stance test, and the eyes open foam surface clinical test for sensory balance were significant, using a repeated measure analysis of variance. The results demonstrated that older adults aim for the OFE target for specific fitness goals can reach moderate intensity and improve their cardiorespiratory endurance. Yet, results for resistance/flexibility/balance are inconclusive. More studies are needed to carefully assess the effectiveness of using OFE.
Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review
Authors: Orilisi Giulia , Mascitti Marco , Togni Lucrezia , Monterubbianesi Riccardo , Tosco Vincenzo , Vitiello Flavia , Santarelli Andrea , Putignano Angelo , Orsini Giovanna
Published: November 2021

Background: COVID-19 disease first appeared in 2019 and quickly spread worldwide, causing a global pandemic. The oral cavity represents a target of SARS-CoV-2, and oral lesions are observed in both non-hospitalized and hospitalized patients. This systematic review aims to investigate the frequency of oral manifestations in COVID-19 hospitalized patients. Methods: An electronic search was conducted in PubMed, Scopus, and Web of Science databases, including articles published up to September 2021. The review protocol was based on PRISMA-P. The risk of bias of the studies was assessed using the Joana Briggs Institute. The certainty of evidence was assessed using the GRADE instrument. Results: Fifty-nine articles were included: 19 case reports, 17 case series, 2 case-control studies, 13 cross-sectional studies, 4 observational studies, and 4 retrospective studies. Oral ulcers, cheilitis, and tongue lesions were more common in patients before hospitalization, while perioral pressure ulcers, macroglossia, blisters, and oral candidiasis were more recurrent in patients during hospitalization. The first could be related directly to COVID-19, while the latter could be caused by medical devices, treatments, prone position, and immunological impairment. Conclusions: An accurate oral examination during the hospital admission of all confirmed COVID-19 cases is encouraged to recognize oral early manifestations and to apply appropriate treatments.
Knowledge, Attitudes and Practices of Eye Health among Public Sector Eye Health Workers in South Africa
Authors: Xulu-Kasaba Zamadonda , Mashige Khathutshelo , Naidoo Kovin
Published: November 2021

In South Africa, primary eye care is largely challenged in its organisational structure, availability of human and other resources, and clinical competency. These do meet the standard required by the National Department of Health. This study seeks to assess the levels of knowledge, attitudes, and practices on eye health amongst Human Resources for eye health (HReH) and their managers, as no study has assessed this previously. A cross-sectional study was conducted in 11 districts of a South African province. A total of 101 participants completed self-administered, close-ended, Likert-scaled questionnaires anonymously. Binary logistic regression analysis was conducted, and values of p < 0.05 were considered statistically significant. Most participants had adequate knowledge (81.6%), positive attitudes (69%), and satisfactory practices (73%) in eye health. HReH showed better knowledge than their managers (p < 0.01). Participants with a university degree, those aged 30–44 years, and those employed for <5 years showed a good attitude (p < 0.05) towards their work. Managers, who supervise and plan for eye health, were 99% less likely to practice adequately in eye health when compared with HReH (aOR = 0.012; p < 0.01). Practices in eye health were best amongst participants with an undergraduate degree, those aged 30–44 years (aOR = 2.603; p < 0.05), and participants with <5 years of employment (aOR = 26.600; p < 0.01). Knowledge, attitudes, and practices were found to be significantly moderately correlated with each other (p < 0.05). Eye health managers have poorer knowledge and practices of eye health than the HReH. A lack of direction is presented by the lack of adequately trained directorates for eye health. It is therefore recommended that policymakers review appointment requirements to ensure that adequately trained and qualified directorates be appointed to manage eye health in each district.
A Comparative Prevalence of Birth Defects between Newborns of Immigrant and Native-Born Mothers in Taiwan: Ten Years of Population-Based Data
Authors: Lin Yu-Jung , Chiou Jeng-Yuan , Huang Jing-Yang , Su Pen-Hua , Chen Jia-Yuh , Yang Hao-Jan
Published: November 2021

In recent years, newborns born to immigrant mothers have accounted for about 10% of the total births in Taiwan. However, little is known about whether there are differences between newborns of immigrant and native-born mothers regarding the prevalence and the possible causes of birth defects. By combining four nationwide databases and assessing all newborns between 2005 and 2014 in Taiwan as research subjects, this study determined the prevalence of birth defects stratified into nine categories (neuronal, facial, cleft, circulatory, respiratory, digestive, urogenital, musculoskeletal and chromosomal abnormalities) in the newborns of immigrant mothers and native-born mothers. We found that the prevalence of any birth defects in newborns of immigrant mothers (ranging from 0.98 to 1.24%) was lower than that of native-born mothers (2.86%). Skeletomuscular system defects are the most common among newborns of women from the main immigrant countries (0.24–0.42%), while circulatory system defects were the most common among newborns of Taiwanese women (0.92%). The risks of all defects remained lower for newborns of immigrant mothers (AORs ranged from 0.37 to 0.47) after controlling for possible confounding variables. The higher rates of birth defects among newborns of native-born mothers may be attributed to an older maternal age at childbirth and a higher prevalence of diabetes than that of immigrant mothers. The findings from this study imply that the prevalence of birth defects between newborns of immigrant and native-born mothers is not similar, as evidenced by a decade of population-based data.
Differences in Characteristics, Hospital Care, and Outcomes between Acute Critically Ill Emergency Department Patients Receiving Palliative Care and Usual Care
Authors: Chang Julia Chia-Yu , Yang Che , Lai Li-Ling , Huang Hsien-Hao , Tsai Shih-Hung , Hsu Teh-Fu , Yen David Hung-Tsang
Published: November 2021

Background: The early integration of palliative care in the emergency department (ED-PC) provides several benefits, including improved quality of life with optimal comfort measures, and symptom control. Whether palliative care could affect the intensive care unit admissions, hospital care and resource utilization requires further investigation. Aim: To determine the differences in inpatient characteristics, hospital care, survival, and resource utilization between patients receiving palliative care (ED-PC) and usual care (UC). Design: Retrospective observational study. Setting/participants: We enrolled consecutive, acute, critically ill patients admitted to the emergency intensive care unit at Taipei Veterans General Hospital from 1 February 2018 to 31 January 2020. Results: A total of 1273 patients were evaluated for unmet palliative care needs; 685 patients received ED-PC and 588 received UC. The palliative care patients were more severely frail (AOR 2.217 (1.295–3.797), p = 0.004), had functional deterioration with three ADLs (AOR 1.348 (1.040–1.748), p = 0.024), biopsychosocial discomfort (AOR 1.696 (1.315–2.187), p < 0.001), higher Taiwan Triage and Acuity Scale 1 (p = 0.024), higher in-hospital mortality (AOR 1.983 (1.540–2.555), p < 0.001), were four times more likely to sign an DNR (AOR 4.536 (2.522–8.158), p < 0.001), and were twice as likely to sign an DNR at admission (AOR 2.1331.619–2.811), p < 0.001). Palliative care patients received less epinephrine (AOR 0.424 (0.265–0.678), p < 0.001), more frequent withdrawal of an endotracheal tube (AOR 8.780 (1.122–68.720), p = 0.038), and more narcotics (AOR1.675 (1.132–2.477), p = 0.010). Palliative care patients exhibited lower 7-day, 30-day, and 90-day survival rates (p < 0.001). There was no significant difference in the hospital length of stay (LOS) (21.2 ± 26.6 vs. 21.7 ± 20.6, p = 0.709) nor total hospital expenses (293,169 ± 350,043 vs. 294,161 ± 315,275, p = 0.958). Conclusion: Acute critically ill patients receiving palliative care were more frail, more critical, and had higher in-hospital mortality. Palliative care patients received less epinephrine, more endotracheal extubation, and more narcotics. There was no difference in the hospital LOS or hospital costs between the palliative and usual care groups. The synthesis of ED-PC is new but achievable with potential benefits to align care with patient goals.
Impact Study on Social Accounting Matrix by Intrabusiness Analysis
Authors: Zlati Monica Laura , Ionescu Romeo-Victor , Antohi Valentin Marian
Published: November 2021

According to the current concerns about social welfare and environmental protection, integrated in a model assimilated to intrabusiness relations, our research started from the analysis of the initial model SAM, which will be transformed in order to develop the SAMI model under six research objectives. The need of improving SAM matrix started to connect it directly to the regional economic systems and continued to a new approach on Input-Output Analysis. Nowadays, SAM describes the intraregional connections between regional economic actors using the role of different income categories. Moreover, SAM can quantify different regional multipliers. All deficiencies previously identified in connection to SAM model have been reviewed and resolved within the proposed SAMI model by the authors of this paper. The purpose of this research is the launch of an absolutely new mathematical model (SAMI) and its practical testing at regional level. This model is able to systematize the links between the local and regional businesses, under the matrix (SAMI) flow, for all kinds of companies and to assist the regional decision, as well. Czamanski was not able to escape from the input-output prison’s approach. This is why he continued to use the linear interdependencies between the industries, economic sectors and economic actors. The income is able only to approximate the individuals and other economic actors’ welfare. If the increase in the average and aggregate income is doubled by an unfair distribution of income in two countries which have the same average income, the effects on welfare vary a lot. A relatively similar effect comes from the government policy differences in income distribution and redistribution.
Cannulation Technique of Vascular Access in Haemodialysis and the Impact on the Arteriovenous Fistula Survival: Protocol of Systematic Review
Authors: Peralta Ricardo , Sousa Luís , Cristóvão António Filipe
Published: November 2021

Background: Based on a literature review of various studies, comparisons between BH and RL are inconclusive regarding some outcomes. However, in the last 5 years, some studies have been published that may contribute to clarifying which cannulation technique (CT) allows better fistula survival. Aim: To review which cannulation technique allows better primary patency of the arteriovenous fistula in haemodialysis patients. Methods: We will include all randomised controlled trials and observational studies that include comparisons among CTs and thus define the benefits and risks of each CT. A PRISMA-compliant systematic review and meta-analysis will be performed in accordance with the quality and homogeneity of studies. A comprehensive search strategy will be applied to the CINAHL, MEDLINE and Embase electronic databases from January 2000 to September 2021. The primary outcome is the arteriovenous fistula primary patency. To assess the risk of bias in randomised controlled trials or quasi-experimental studies, we will use the tool Revised Cochrane Risk-of-Bias Tool for Randomized Trials (RoB 2). For nonrandomised studies, the Risk of Bias In Non-Randomized Studies of Interventions (ROBINS-I) will be used. Discussion: The evidence generated from this systematic review of current evidence could inform the design and implementation of continuous quality improvement programs in cannulation techniques in haemodialysis patients, as well as contributing to improving the curricula within haemodialysis courses. This protocol was registered with the National Institute for Health Research PROSPERO database prior to commencement (registration number CRD42021237050).
New Self-Report Measures of Commuting Behaviors to University and Their Association with Sociodemographic Characteristics
Authors: Palma-Leal Ximena , Rodríguez-Rodríguez Fernando , Campos-Garzón Pablo , Castillo-Paredes Antonio , Chillón Palma
Published: November 2021

Active commuting provides an opportunity for increased physical activity levels by a simple, inexpensive, and easy way to be incorporated in daily routines and could be considered a steppingstone for achieving a sustainable society since it provides physical, psychological, environmental, and economic benefits. Objective: (a) to describe the commuting patterns to and from university in students regarding gender, (b) to provide new self-report variables to measure the active commuting behavior, and (c) to examine the sociodemographic characteristics associated with commuting behaviors. Material and Methods: A total of 1257 university students (52.4% females) participated (22.4 ± 5.6 years old) from three Chilean universities located in different cities. Results: 56.1% of women and 42.0% men use public bus to and from university. The commuting energy expenditure was higher in active commuting followed by public and private modes of commuting (p < 0.001). The most active commuters were those older (men: OR = 3.637; 95% CI = 1.63, 8.10; women: OR = 8.841; 95% CI = 3.94, 13.78), those who lived in university residence (men: OR = 12.432; 95% CI = 4.39, 35.19; women: OR = 3.952; 95% CI = 1.31, 11.85), belonged to low socioeconomic level (men: OR = 3.820; 95% CI = 1.43, 10.18; women: OR = 4.936; 95% CI = 1.63, 14.90), and to public universities (men: OR = 26.757; 95% CI = 10.63, 67.34; women: OR = 8.029; 95% CI = 3.00, 21.48). Conclusion: The sociodemographic characteristics may influence in the mode of commuting to university. New variables of commuting behaviors may be efficient to quantify the physical activity.
Current Thoughts of Notch’s Role in Myoblast Regulation and Muscle-Associated Disease
Authors: Gerrard Jeffrey C. , Hay Jamison P. , Adams Ryan N. , Williams James C. , Huot Joshua R. , Weathers Kaitlin M. , Marino Joseph S. , Arthur Susan T.
Published: November 2021

The evolutionarily conserved signaling pathway Notch is unequivocally essential for embryogenesis. Notch’s contribution to the muscle repair process in adult tissue is complex and obscure but necessary. Notch integrates with other signals in a functional antagonist manner to direct myoblast activity and ultimately complete muscle repair. There is profound recent evidence describing plausible mechanisms of Notch in muscle repair. However, the story is not definitive as evidence is slowly emerging that negates Notch’s importance in myoblast proliferation. The purpose of this review article is to examine the prominent evidence and associated mechanisms of Notch’s contribution to the myogenic repair phases. In addition, we discuss the emerging roles of Notch in diseases associated with muscle atrophy. Understanding the mechanisms of Notch’s orchestration is useful for developing therapeutic targets for disease.
Common Determinants of Dental Caries and Obesity in Children: A Multi-Ethnic Nested Birth Cohort Study in the United Kingdom
Authors: Uerlich Magdalena F. , Baker Sarah R. , Day Peter F. , Brown Lucy , Vettore Mario V.
Published: November 2021

The article examines the common determinants of childhood dental caries and obesity. Longitudinal data from the Born in Bradford cohort study (BiB1000) (n = 1735) and dental data (dental general anaesthetics (GA) and oral health survey 2014/15) (n = 171) were used to test a framework on the social determinants of childhood dental caries (decayed, missing, filled teeth (dmft) index) and obesity (body mass index (BMI)). The BiB1000 data were collected at pregnancy week 26–28 and after birth at 6, 12, 18, 24 and 36 months. The determinants were demographics, wellbeing, socio-economic status (SES), dietary behaviours and physical activity behaviour of the children. Missing data were accounted for through multiple imputation (MI). The framework was tested through structural equation modelling. Overall, the model fit was adequate. No alcohol consumption of the mother after giving birth, higher frequency of child drinking sugar-sweetened beverages, emotional and behavioural difficulties of the child and being male were directly associated with both BMI and dental caries. Caregivers uninvolved or indulgent feeding style were associated with higher BMI and less dental caries. Social deprivation was associated with lower BMI and higher dmft. Five determinants were directly associated with BMI only. Fifteen indirect paths were significant for both child dental caries and BMI. The findings suggest common determinants for both childhood obesity and dental caries. Common risk factor approach seems appropriate for planning future health promotion programmes.
Sensemaking Processes during the First Months of COVID-19 Pandemic: Using Diaries to Deepen How Italian Youths Experienced Lockdown Measures
Authors: Procentese Fortuna , Gatti Flora , Ceglie Emiliano
Published: November 2021

The COVID-19 pandemic has brought about disruptive changes in individuals’ lives, breaking the established systems of meaning worldwide. Indeed, in the first months of the pandemic, with individuals being forced to stay at home for a prolonged time to contain the spread of the virus, the need to build new meanings to understand and face this crisis emerged. Building on this, the present study contributes to the understanding of how sensemaking processes were shaped in the face of COVID-19 collective trauma during the very first months of the pandemic. Hence, 36 Italian young adults aged between 21 and 25 submitted daily diary entries for two weeks (T1 was the third week of Italian National lockdown; T2 was the penultimate week before the ease of such stay-at-home orders), resulting in 504 texts. The stimulus was always “Could you describe your daily experience and feelings?”. The Grounded Theory was used. Thus, 15 categories emerged, grouped into three macro-categories. The core category was sensemaking as adaptation. Indeed, the sensemaking process seemed to be a strategy to adapt to the new circumstances related to the lockdown, facing the emotional, cognitive, and activation reactions such conditions by relying on coping strategies and the redefinition of primary as well as broader social relationships.
Differential Cutaneous Thermal Sensitivity in Humans: Method of Limit vs. Method of Sensation Magnitude
Authors: Seo Yongsuk , Kim Jung-Hyun
Published: November 2021

Introduction: The method of limits (MLI) and method of level (MLE) are commonly employed for the quantitative assessment of cutaneous thermal sensitivity. Thermal sensation and thermal comfort are closely related and thermal sensations evoked from the peripheral thermoreceptors play an important role in thermoregulatory response to maintain normal body temperature. The purpose of this study was to compare the regional distribution of cutaneous warm and cold sensitivity between MLI and the method of sensation magnitude (MSM). Method: Twenty healthy men completed MLI and MSM to compare the regional distribution of cutaneous warm and cold sensitivity in the thermal neutral condition. The subjects rested on a bed in a supine position for 20 min. Next, the cutaneous thermal sensitivity of ten body sites was assessed by the means of MLI and MSM for both warmth and cold stimuli. Results: The absolute mean heat flux in MLI and thermal sensation magnitude in MSM showed significantly greater sensitivity to cold than to warm stimulation (p < 0.01), together with a similar pattern of regional differences across ten body sites. Both sensory modalities indicated acceptable reliability (SRD%: 6.29–8.66) and excellent reproducibility (ICC: 0.826–0.906; p < 0.01). However, the Z-sore distribution in MSM was much narrower than in MLI, which may limit the test sensitivity for the detection of sensory disorders and/or comparison between individuals. Conclusion: The present results showed that both MLI and MSM are effective means for evaluating regional cutaneous thermal sensitivity to innocuous warm and cold stimulations to a strong degree of reliability and reproducibility.
Degradation Characteristics of Carbon Tetrachloride by Granular Sponge Zero Valent Iron
Authors: Zhu Xueqiang , Li Yuncong , Han Baoping , Feng Qiyan , Zhou Lai
Published: November 2021

Granular sponge zero valent iron (ZVI) was employed to degrade carbon tetrachloride (CCl4). The effects of acidic washing, initial solution pH, and ZVI dosage on CCl4 degradation were investigated. Results showed that CCl4 was effectively removed by ZVI and approximately 75% of CCl4 was transformed into chloroform through hydrogenolysis. The rate of chloroform transformation was slower compared to that of CCl4, resulting in chloroform accumulation. CCl4 degradation was a pseudo first-order process. The observed pseudo first-order reaction rate constant (kobs) for CCl4 and chloroform were 0.1139 and 0.0109 h−1, respectively, with a ZVI dosage of 20 g/L and an initial CCl4 concentration of 20 mg/L. Surface acidic washing had a negligible effect on CCl4 degradation with ZVI. The kobs for CCl4 degradation increased linearly with increasing ZVI dosage and the optimal dosage of ZVI was 20 g/L based on the surface area-normalized rate constants. The negative relationship between kobs and the solution pH indicated that the degradation of CCl4 by ZVI performed better under weakly acidic conditions.
Overtreatment in Restorative Dentistry: Decision Making by Last-Year Dental Students
Authors: Moreno Triana , Sanz José Luis , Melo María , Llena Carmen
Published: November 2021

To evaluate the tendency for overdiagnosis and overtreatment upon different clinical situations among last-year students from the degree in dentistry from Valencia University (Spain) during the 2018–2019 course. A questionnaire consisting of 10 case exemplifications examining the diagnosis, treatment, and clinician’s attitude towards different common clinical situations regarding restorative dentistry was designed. Fifty-two students were surveyed, from whom 42 completed the questionnaire (80.77%). Data were analyzed descriptively. A total of 58.8% of the students correctly identified an early carious lesion in the occlusal surface of a molar, while 63.2% would perform unnecessary complementary tests for its diagnosis. The treatment for carious lesions in different evolutive phases with a vital pulp was correct between 51.2 and 92.7% of the cases. The treatment for irreversible pulp pathology and the restoration of the tooth with root canal treatment were adequately selected in 56.1% and 78.3% of the cases, respectively. For the repair of a faulty restoration, an overtreatment was proposed by 87.8% of the students. A tendency to perform unnecessary complementary tests for caries diagnosis was observed. Treatment caries proposals were in accordance with available evidence in the majority of the cases. Students tended to overtreat defective restorations and would perform unnecessary treatments in medically compromised patients.
Pacing Profiles of Middle-Distance Running World Records in Men and Women
Authors: Casado Arturo , González-Mohíno Fernando , González-Ravé José María , Boullosa Daniel
Published: November 2021

The aims of the current study were to compare the pacing patterns of all-time 800 m, 1500 m and mile running world records (WRs) and to determine whether differences exist between sexes, and if 800 m and 1500 m WRs were broken during championship or meet races. Overall and lap times for men and women’s 800 m, 1500 m, and mile WRs from World Athletics were collected when available and subsequently compared. A fast initial 200 m segment and a decrease in speed throughout was found during 800 m WRs. Accordingly, the first 200 m and 400 m were faster than the last 200 m and 400 m, respectively (p < 0.001, 0.77 ≤ ES ≤ 1.86). The first 400 m and 409 m for 1500 m and mile WRs, respectively, were faster than the second lap (p < 0.001, 0.74 ≤ ES ≤ 1.46). The third 400 m lap was slower than the last 300 m lap and 400 m lap for 1500 m and mile WRs, respectively (p < 0.001, 0.48 ≤ ES ≤ 1.09). No relevant sex-based differences in pacing strategy were found in any event. However, the first 409 m lap was faster than the last 400 m lap for men but not for women during mile WRs. Women achieved a greater % of WRs than men during championships (80% vs. 45.83% in the 800 m, and 63.63% vs. 31.58% in the 1500 m, respectively). In conclusion, positive, reverse J-shaped and U-shaped pacing profiles were used to break 800 m, men’s mile and 1500 m, and women’s mile WRs, respectively. WRs are more prone to be broken during championships by women than men.
Influence of On-Sight and Flash Climbing Styles on Advanced Climbers’ Route Completion for Bouldering
Authors: Morenas Jesús , Luis del Campo Vicente , López-García Sergio , Flores Lucía
Published: November 2021

Route previewing has been established as a critical parameter in indoor climbing performance, as it could determine the success or failure in ascending the route. We addressed the effect of different types of previews on output climbing performance. Twenty-one advanced climbers (7b and 7c+ climbing grade) were required to complete 18 routes, rated at 6c, according to the French Rating Scale of Difficulty. Each climber previewed the route under three conditions: “No-previewing”, “video-model previewing”, and “real-model previewing”. Output climbing performance was assessed in terms of route completion. The results showed differences on output climbing performance between types of preview. Specifically, the climbers achieved more successful attempts at climbing to the “Top” of the wall when inspecting the route with the “real-model previewing” condition, compared to the other conditions of preview. On the contrary, the climbers displayed more failed attempts in climbing the route with the “on-sight” condition, compared to the “flash” styles (“video-model” and “real-model”). The preview of the route, including performance of a real/video-projected model manipulating climbing holds, seems to increase the opportunities to climb the boulder successfully, attuning climbers to information specifying ascending actions. Climbing coaches should reinforce the design of representative training, using flash styles, to promote movement solutions for route completion.
Less Is More? The Association between Survival and Follow-Up Protocol after Treatment in Oral Cavity Cancer Patients from a Betel Quid-Prevalent Region
Authors: Liu Shih-An , Wang Chen-Chi , Jiang Rong-San , Tung Yu-Chi
Published: November 2021

The optimal follow-up protocol after treatment of oral cavity cancer patients is still debatable. We aimed to investigate the impact of frequency of different imaging studies and follow-up visits on the survival of oral cavity cancer patients. The current study retrospectively reviewed oral cavity cancer patients who underwent surgical intervention in our hospital. Basic demographic data, tumor-related features, treatment modalities, imaging studies, and clinic visits were recorded. Cox proportional hazard model was used to examine the influence of variables on the survival of oral cavity cancer patients. In total, 741 patients with newly diagnosed oral cavity cancer were included in the final analysis. Overall, the frequency of imaging studies was not associated with survival in the multivariate analysis, except PET scan (hazard ratio [HR]: 5.30, 95% confidence interval [CI]: 3.57–7.86). However, in late-stage and elder patients, frequent head and neck CT/MRI scan was associated with a better prognosis (HR: 0.55, 95% CI: 0.36–0.84; HR: 0.52, 95% CI: 0.30–0.91, respectively). In conclusion, precision medicine is a global trend nowadays. Different subgroups may need different follow-up protocols. Further prospective study is warranted to clarify the relationship between frequency of image studies and survival of oral cavity cancer patients.
Brazilian Food Banks: Overview and Perspectives
Authors: Tenuta Natalia , Barros Thaís , Teixeira Romero Alves , Paes-Sousa Rômulo
Published: November 2021

In recent decades food banks have become a worldwide response to the contradicting the coexistence of food losses and waste, on the one hand, and hunger and food insecurity on the other. In Brazil, food banks had a rapid expansion, becoming the object of public policy on Food and Nutrition Security and of non-profit private institutions. Our study presents an unprecedented overview of all the food banks currently active in the Brazilian territory, discussing their performances and perspectives. We conducted descriptive research, aiming to characterize the number, spatial distribution, performance, and modalities of operation of the Brazilian food banks. We mapped 217 active food banks and they all participated in the study. The results revealed the important capillarity of the food banks, which exist in all 27 Brazilian federative units, but also demonstrate the potential and need for expansion. Most of the Brazilian food banks has commercial establishments as their largest donor partners and have fruits and vegetables as their most donated items. They mostly complement the feeding of families at social risk and children served by social institutions. Food and nutrition education actions are offered by all the studied units to donor partners and beneficiary institutions and families.
Microbiome—Friend or Foe of Pancreatic Cancer?
Authors: Daniluk Jaroslaw , Daniluk Urszula , Rogalski Pawel , Dabrowski Andrzej , Swidnicka-Siergiejko Agnieszka
Published: November 2021

Pancreatic ductal adenocarcinoma is one of the deadliest human neoplasms. Despite the development of new surgical and adjuvant therapies, the prognosis remains very poor, with the overall survival rate not exceeding 9%. There is now increasing evidence that the human microbiome, which is involved in many physiological functions, including the regulation of metabolic processes and the modulation of the immune system, is possibly linked to pancreatic oncogenesis. However, the exact mechanisms of action are poorly understood. Our review summarizes the current understanding of how the microbiome affects pancreatic cancer development and progression. We discuss potential pathways of microbe translocation to the pancreas, as well as the mechanism of their action. We describe the role of the microbiome as a potential marker of pancreatic cancer diagnosis, progression, and survival. Finally, we discuss the possibilities of modifying the microbiome to improve treatment effectiveness for this deadly disease.
Mid-Diastolic Events (L Events): A Critical Review
Authors: Di Virgilio Emanuele , Monitillo Francesco , Santoro Daniela , D’Alessandro Silvia , Guglielmo Marco , Baggiano Andrea , Fusini Laura , Memeo Riccardo , Rabbat Mark G. , Favale Stefano , Cameli Matteo , Guaricci Andrea Igoren , Pontone Gianluca
Published: November 2021

Mid-diastolic events (L events) include three phenomena appreciable on echocardiography occurring during diastasis: mid-diastolic transmitral flow velocity (L wave), mid-diastolic mitral valve motion (L motion), and mid-diastolic mitral annular velocity (L’ wave). L wave is a known marker of advanced diastolic dysfunction in different pathological clinical settings such as left ventricle and atrial remodeling, overloaded states, and cardiomyopathies. Patients with L events have poor outcomes with a higher risk of developing heart failure symptoms and arrhythmic complications, including sudden cardiac death. The exact mechanism underlying the genesis of mid-diastolic events is not fully understood, just as the significance of these events in healthy young people or their presence at the tricuspid valve level. We also report an explicative case of a patient with L events studied using speckle tracking imaging of the left atrium and ventricle at the same reference heartbeat supporting the hypothesis of a post-early diastolic relaxation or a “two-step” ventricular relaxation for L wave genesis. Our paper seeks to extend knowledge about the pathophysiological mechanisms on mid-diastolic events and summarizes the current knowledge.
Noncoding RNAs Interactions in Hepatic Stellate Cells during Hepatic Fibrosis
Authors: Sulaiman Siti Aishah , Dorairaj Vicneswarry , Abdul Ghafar Khairun Nur , Abdul Murad Nor Azian
Published: November 2021

Hepatic fibrosis is a reversible wound healing process following liver injury. Although this process is necessary for maintaining liver integrity, severe excessive extracellular matrix accumulation (ECM) could lead to permanent scar formation and destroy the liver structure. The activation of hepatic stellate cells (HSCs) is a key event in hepatic fibrosis. Previous studies show that most antifibrotic therapies focus on the apoptosis of HSCs and the prevention of HSC activation. Noncoding RNAs (ncRNAs) play a substantial role in HSC activation and are likely to be biomarkers or therapeutic targets for the treatment of hepatic fibrosis. This review summarizes and discusses the previously reported ncRNAs, including the microRNAs, long noncoding RNAs, and circular RNAs, highlighting their regulatory roles and interactions in the signaling pathways that regulate HSC activation in hepatic fibrosis.
Implicit Solitary Waves for One of the Generalized Nonlinear Schrödinger Equations
Authors: Kudryashov Nikolay A.
Published: November 2021

Application of transformations for dependent and independent variables is used for finding solitary wave solutions of the generalized Schrödinger equations. This new form of equation can be considered as the model for the description of propagation pulse in a nonlinear optics. The method for finding solutions of equation is given in the general case. Solitary waves of equation are obtained as implicit function taking into account the transformation of variables.
Minimally Invasive Approaching in Hip Surgery—An Anatomical Investigation of 20 Specimens
Authors: Schopper Clemens , Traxler Hannes , Schauer Bernhard , Hipmair Günter , Gotterbarm Tobias , Luger Matthias
Published: November 2021

Background and objectives: Based on the preparation of 20 formalin-fixed anatomical cadavers, the feasibility of the anterior, minimally invasive approach to the hip joint was investigated in each side of the body. The hypothesis of the study was that the Lateral Femoral Cutaneous Nerve can be spared under the use of this approach. Materials and Methods: The anterior approach to the hip was performed via an incision of 8 cm. The position of the nerve was noticed in relation to the skin incision, and the distance was measured in millimeters. The nerves main, gluteal and femoral trunk were distinguished and investigated for injury. Results: No injury of the main trunk was noticed. The average distance of the main trunk to the skin incision was 14.9 and 15.05 mm in the medial direction, respectively (p < 0.001). Injury of the gluteal branch has to be considered at an overall rate of 40%. Conclusions: The anterior, minimally invasive approach to the hip joint can be performed without injury of the Lateral Femoral Cutaneous Nerve.
Impact of Personal Protective Equipment on Out-of-Hospital Cardiac Arrest Resuscitation in Coronavirus Pandemic
Authors: Ko Hye-Young , Park Jong-Eun , Jeong Da-Un , Shin Tae-Gun , Sim Min-Seob , Jo Ik-Joon , Lee Gun-Tak , Hwang Sung-Yeon
Published: November 2021

Background and Objectives: This retrospective study evaluated the clinical impact of enhanced personal protective equipment (PPE) on the clinical outcomes in patients with out-of-hospital cardiac arrest. Moreover, by focusing on the use of a powered air-purifying respirator (PAPR), we investigated the medical personnel’s perceptions of wearing PAPR during cardiopulmonary resuscitation. Materials and Methods: According to the arrival time at the emergency department, the patients were categorized into a conventional PPE group (1 August 2019 to 20 January 2020) and an enhanced PPE group (21 January 2020, to 31 August 2020). The primary outcomes of this analysis were the return of spontaneous circulation (ROSC) rate. Additionally, subjective perception of the medical staff regarding the effect of wearing enhanced PPE during cardiopulmonary resuscitation (CPR) was evaluated by conducting a survey. Results: This study included 130 out-of-hospital cardiac arrest (OHCA) patients, with 73 and 57 patients in the conventional and enhanced PPE groups, respectively. The median time intervals to first intubation and to report the first arterial blood gas analysis results were longer in the enhanced PPE group than in the conventional PPE group (3 min vs. 2 min; p = 0.020 and 8 min vs. 3 min; p < 0.001, respectively). However, there were no significant differences in the ROSC rate (odds ratio (OR) = 0.79, 95% confidence interval (CI): 0.38–1.67; p = 0.542) and 1 month survival (OR 0.38, 95% CI: 0.07–2.10; p = 0.266) between the two groups. In total, 67 emergent department (ED) professionals responded to the questionnaire. Although a significant number of respondents experienced inconveniences with PAPR use, they agreed that PAPR was necessary during the CPR procedure for protection and reduction of infection transmission. Conclusion: The use of enhanced PPE, including PAPR, affected the performance of CPR to some extent but did not alter patient outcomes. PAPR use during the resuscitation of OHCA patients might positively impact the psychological stability of the medical staff.
Vitamin D Deficiency Is a Potential Risk for Blood Pressure Elevation and the Development of Hypertension
Authors: Karadeniz Yusuf , Özpamuk-Karadeniz Fatma , Ahbab Süleyman , Ataoğlu Esra , Can Günay
Published: November 2021

Background and objectives: Hypertension is a global health problem and a major risk factor for cardiovascular diseases. Vitamin D deficiency is closely related to high blood pressure and the development of hypertension. This study investigated the relationship between the vitamin D and blood pressure status in healthy adults, and their 8-year follow-up was added. Materials and Methods: A total of 491 healthy middle-aged participants without any chronic illness, ages 21 to 67 at baseline, were divided into two groups as non-optimal blood pressure (NOBP) and optimal blood pressure (OBP). NOBP group was divided into two subgroups: normal (NBP) and high normal blood pressure (HNBP). Serum 25-hydroxy vitamin D levels were measured with the immunoassay method. 8-year follow-up of the participants was added. Results: The average vitamin D level was detected 32.53 ± 31.50 nmol/L in the OBP group and 24.41 ± 14.40 nmol/L in the NOBP group, and a statistically significant difference was found (p < 0.001). In the subgroup analysis, the mean vitamin D level was detected as 24.69 ± 13.74 and 24.28 ± 14.74 nmol/L in NBP and HNBP, respectively. Together with parathyroid hormone, other metabolic parameters were found to be significantly higher in the NOBP. During a median follow-up of 8 years, higher hypertension development rates were seen in NOBP group (p < 0.001). Conclusions: The low levels of vitamin D were significantly associated with NBP and HNBP. The low levels of vitamin D were also associated with the development of hypertension in an 8-year follow-up.
The Concentration of CMKLR1 Expression on Clinicopathological Parameters of Colorectal Cancer: A Preliminary Study
Authors: Kiczmer Paweł , Mielcarska Sylwia , Chrabańska Magdalena , Dawidowicz Miriam , Kula Agnieszka , Rynkiewicz Magdalena , Seńkowska Alicja Prawdzic , Waniczek Dariusz , Piecuch Jerzy , Jopek Janusz , Kajor Maciej , Świętochowska Elżbieta
Published: November 2021

Background and Objectives: Colorectal cancer (CRC) is the second-most common cause of cancer-related deaths worldwide. Angiogenesis is crucial for cancer growth, infiltration of surrounding tissues, and metastasis and plays a key role in the pathogenesis of CRC. Chemerin/chemokine-like receptor 1 (CMKLR1) is one of the biochemical pathways involved in the regulation of angiogenesis in solid tumors. The aim of the study was to assess the CMKLR1 level in tumor and margin tissues of CRC in relation to histopathological parameters: microvessel density (MVD), budding, tumor-infiltrating lymphocytes (TILs), TNM scale, and grading. Materials and Methods: The study involved 43 samples of tumor and margin tissues obtained from CRC patients. To assess the concentration of CMKLR1 a commercially available enzyme-linked immunosorbent assay kit was used. For 35 cases, we performed CD34 immunostaining. The MVD, budding, and TILs were assessed using a light microscope. Results: The levels of CMKLR1 in both tumor and margin were negatively correlated with MVD and budding. CMKLR1 concentration in margin was higher in tissues with lymphocytic infiltration. Conclusions: Low vascularity and low budding are associated with higher CMKLR1 expression. CMKLR1 might play a multifunctional role in CRC pathogenesis by influencing tumor budding and peritumoral lymphocytic infiltration.
Analytical Performance of the Sysmex HISCL HBsAg Assay and Comparison with the Roche Elecsys HBsAg II Quant Assay in the Quantification of Hepatitis B Surface Antigen
Authors: Park Joonhong , Bae Taewon , Cho Yonggon , Kim Dalsik , Lee Jaehyeon
Published: November 2021

Background and Objectives: This study aims to estimate the analytical performance of the Sysmex HISCL HBsAg assay and to assess the analytical correlation with the Roche Elecsys HBsAg II quant assay with clinical samples and the WHO International Standard (IS). Materials and Methods: The intra-assay precision, linearity, assay limitation, accuracy, and comparative evaluation of the HISCL HBsAg assay were estimated. Results: Extrapolating from the plot of the average total allowable error versus the reference value, an accuracy goal of 20% would be achieved around a limit of quantification (LoQ) of 0.014867 IU/mL. The percentage of biases for each level of the WHO IS measured by the two assays were less than 15%, except for the WHO 3rd IS, for which the HISCL HBsAg assay achieved a percentage of bias of 33%. In the comparative evaluation, Passing–Bablok regression analysis did not reveal any significant deviation from linearity between the two assays (y = −48.6998 + 1.9206x; p = 0.79 by the CUSUM test for linearity). The mean difference of the quantitative HBsAg level between the two assays was 1762.5 IU/mL in the Bland–Altman plot. Conclusions: The HISCL HBsAg assay, with a highly sensitive LoQ of 0.03 IU/mL, showed similar analytical performance in HBsAg quantification to the Elecsys HBsAg II quant assay and may be helpful in obtaining better diagnoses and therapeutic strategies for treating HBV infections.
Current Status and Future Trend of Dominant Commercial Reverse Osmosis Membranes
Authors: Kurihara Masaru
Published: November 2021

Since 2000, seawater reverse osmosis method has been a dominant desalination technology against the distillation method in the global market. The large project called “Mega-SWRO” (half mega-ton per day and larger) plant in the Middle East is quite popular making full use of the combination with solar energy. Today, the price of desalinated water is affordable at as low as $0.28/m3 to $0.53/m3. Likewise, dominant commercial reverse osmosis membrane is a cross-linked fully aromatic polyamide composite membrane-spiral wound element including FT-30 (DuPont Water Solution) and UTC-80 (Toray Industries., Inc., Otsu, Shiga, Japan). The said membranes are much superior in terms of performance compared to the cellulose triacetate membranes-hollow fiber for variety of applications including seawater desalinations, brackish water desalination, wastewater reuse, ultra-pure production for semiconductor, home-use water purifier, etc. SWCC of Saudi Arabia has announced that it intends to shift from cellulose triacetate hollow fiber to spiral wound RO membranes at all of its plants. Furthermore, the state-sponsored R&D on membrane and membrane process has been put into practice in major countries, including Japan and Korea, which contributed to the progress of membrane science and membrane process, suitable for spiral-wound polyamide membranes. SWCC has announced their plans for SWRO, mainly focusing on brine mining to obtain precious materials from the brine of SWRO. New and innovative brine-mining technology has been introduced for green desalination.
Membranes for the Gas/Liquid Phase Separation at Elevated Temperatures: Characterization of the Liquid Entry Pressure
Authors: Claramunt Sara , Völker Florian , Gerhards Uta , Kraut Manfred , Dittmeyer Roland
Published: November 2021

Hydrophobic membranes were characterized at elevated temperatures. Pressure was applied at the feed and permeate side to ensure liquid phase conditions. Within this scope, the applicability of different polymeric and ceramic membranes in terms of liquid entry pressure was studied using water. The Visual Method and the Pressure Step Method were applied for the experimental investigation. The results show the Pressure Step Method to be an early detection method. The tests at higher pressure and temperature conditions using the Pressure Step Method revealed the temperature as being the main factor affecting the liquid entry pressure. Novel LEP data up to 120 °C and 2.5 bar were obtained, which broadens the application range of hydrophobic membranes.