bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PELATIHAN KADER POSYANDU TERHADAP PENGETAHUAN TENTANG PEMANTAUAN PERTUMBUHAN DAN PERKEMBANGAN BALITA DI WILAYAH KERJA PUSKESMAS BONTORAMBA DESA KARELOE KABUPATEN JENEPONTO
Authors: Sri Sri Nurindasari
Published: November 2024

Pertumbuhan dikaitkan dengan perubahan ukuran, jumlah, atau dimensi pada tingkat seluler, organ, atau individu sedangkan Perkembangan ditandai dengan adanya proses diferensiasi sel, jaringan, organ, dan sistem organ yang masing-masing berevolusi untuk dapat menjalankan fungsinya. Tujuan penelitian ini untuk mengetahui Pengaruh Pelatihan Kader Posyandu Terhadap pengetahuan tentang Pemantauan pertumbuhan dan perkembangan Balita diWilayah Kerja Puskesmas Bontoramba Desa Kareloe Kabupaten Jeneponto. Desain penelitian ini adalah jenis penelitian kuantitatif dengan desain penelitian pre eksperimental design dengan rancangan one group pre and posttest design, dengan sampel 37 responden. Penelitian ini menggunakan metode  uji Paired sample test dengan kemaknaan  p < 0,05. Didapatkan hasil  sebagai berikut : nilai p value = 0,000 (<0,05). Sehingga dapat di simpulkan ada pengaruh Pelatihan Kader Posyandu Terhadap pengetahuan tentang Pemantauan pertumbuhan dan perkembangan Balita diWilayah Kerja Puskesmas Bontoramba Desa Kareloe Kabupaten Jeneponto.
PENGARUH PENERAPAN METODE PROBLEM BASED LEARNING (PBL) TERHADAP HASIL BELAJAR DALAM MATA KULIAH PELAYANAN KB DAN KESEHATAN REPRODUKSI PADA PROGRAM STUDI DIPLOMA TIGA KEBIDANAN UNIVERSITAS PATRIA ARTHA
Authors: Anha Fitriana Jufri
Published: November 2024

Penelitian ini bertujuan mengetahui pengaruh penerapan PBL terhadap hasil belajar mahasiswa serta kaitannya dengan Indeks Prestasi Semester I, Self Directed Learning (SDL) dan kinerja tutor.Metode penelitian ini menggunakan rancangan pre-eksperimental denganpendekatan kuantitatif, menggunakan desain Intact Group Comparison, terdiri dari duakelompok penelitian, yaitu kelompok perlakuan (PBL) dan kelompok kontrol (non PBL). Penelitian dilakukan di universitas patria artha pada bulan januari – mei 2023. SampelSampel sebanyak 120 mahasiswa Semester II, terbagi dalam 3 kelas, yang terdiri dari 1 kelas sebagai kelompok perlakuan dan 2 kelas sebagai kelompok kontrol. Analisis data melalui uji t tidak berpasangan, Mann-Whitney, regresi berganda, dan Korelasi Pearson. Kemaknaan hasil uji ditentukan berdasarkan nilai p<0,05.Hasil penelitian menunjukkan bahwa terdapat pengaruh metode PBL terhadap nilai ujian tulis materi Pelayanan KB dan Kesehatanreproduksi dengan mempertimbangkan faktor IP Semester sebelumnya (IP Semester I)(p=0,001), tidak terdapat pengaruh metode PBL terhadap SDL (p=0,548), tidak terdapathubungan bermakna antara kinerja tutor dengan nilai ujian tulis materi KB (p=0,360),terdapat hubungan bermakna antara kinerja tutor dengan kemampuan SDL mahasiswa(p<0,001), dengan nilai korelasi 0,559 yang menunjukkan korelasi positif dengan kekuatan korelasi sedang.Simpulan bahwa Implementasi metode PBL berpengaruh terhadap nilai ujian tulis, metode PBL tidak berhubungan dengan kemampuan SDL mahasiswa, kinerja tutor tidak berhubungan dengan nilai ujian tulis, namun berhubungan dengan kemampuan SDL mahasiswa. Perlu disempurnakannya penerapan metode PBL pada materi Pelayanan KB danKesehatan Reproduksi, serta meningkatkan pelaksanaan tutor training yang lebih optimal,intensif, dan berkesinambungan.
IMPLEMENTASI KEBIJAKAN REKAM MEDIS ELEKTRONIK DALAM MENINGKATKAN PELAYANAN RSUD LABUANG BAJI KOTA MAKASSAR
Authors: Musyawir Andi Khairul Musyawir , Abidin Widya Wati Astuti
Published: November 2024

Perkembangan teknologi dan sistem informasi di bidang kesehatan saat ini sedang mengalami kemajuan pesat. Salah satu konsep yang saat ini menjadi fokus adalah Rekam Medis Elektronik. Masalah yang ditemukan pada RSUD Labuang Baji Kota Makassar pengisian informasi klinis, pengelolaan informasi RME, cadangan data, transfer isi RM. Tujuan penelitian ini untuk mengetahui implementasi kebijakan peraturan menteri kesehatan rekam medis elektronik dalam meningkatkan pelayanan RSUD Labuang Baji Kota Makassar. Metode yang digunakan penelitian kualitatif yang bertujuan untuk menganalisis dan mendeskripsikan fenomena atau objek penelitian melalui aktivitas sosial, sikap dan persepsi orang secara individu atau kelompok. Hasil Penelitian menunjukkan bahwa Registrasi Pasien, Pendistribusian data RME, Pengisian informasi klinis, Pengelolaan Informasi RME sudah melakukan sesuai dengan PMK RI Rekam Medis, akan tetapi pada bagian indeks tidak ada bagiannya dan pengindeksan penyakit tidak ada. Pengimputan Data Untuk klaim Pembiayaan sudah melakukan sesuai dengan PMK RI Rekam Medis dan diagnosis sudah pakai ICD 9 dan 10. Penyimpanan RME prosedur dan kebijakan masih pakai versi manual. Komputasi awan berjalan dengan baik dan sesuai dengan PMK. Penyimpanan diletakan pada flasdisk, server, dan pada tempat yang berbeda di luar pulau Sulawesi Selatan. Penjaminan Mutu, dan Transfer Isi RME sudah sesuai PMK RI Rekam Medis dan standar yang diberikan oleh KEMENKES. Adapun saran kepada pihak rumah sakit agar dapat menyesuaikan dengan PMK RI No. 24 Tahun 2022 tentang Rekam Medis.
PENGARUH PENDIDIKAN KESEHATAN TERHADAP PENGETAHUAN REMAJA TENTANG KESEHATAN REPRODUKSI DI SMA NEGERI 19 GOWA
Authors: Unna Asmaul Husnah , Jumrana
Published: November 2024

Latar Belakang. Masa remaja merupakan priode terjadinya pertumbuhan dan perkembanganyang pesat baik secara fisik, psikologis maupun intelektual. Sifat khas remaja mempunyairasa keingintahuan yang besar, menyukai petualangan dan tantangan serta cenderung beranimenanggung resiko atas perbuatannya tanpa didahului oleh pertimbangan yang matang. Olehkarena itu pentingnya dilakukan pendidikan kesehatan tentang kesehatan reproduksi remaja.Tujuan. Mengidentifikasi pengetahuan remaja sebelum dan sesudah dilakukan pendidikankesehatan reproduksi di SMA Negeri 19 Gowa.Metode. penelitian ini menggunakan desain pre-eksperiment. Pendekatan yang dilakukandalam penelitian ini adalah dengan teknik one group pre-test and posttest design. Kuisionersebagai alat ukur untuk mengetahui pengetahuan remaja siswa kelas XI SMA Negeri 19 Gowa.Hasil. Berdasarkan hasil penelitian diketahui bahwa tingkat pengetahuan remaja sebelumdiberikan pendidikn kesehatan masih banyak yang kuran yaitu 45 orang (75%) dan selebihnyabaik yaitu 15 orang (25%), namun setelah diberikannya pendidikan kesehatan terjadipeningkatan pengetahuan tentang kesehatan reproduksi pada responden yaitu 55 orang(91,7%) dan selebihnya masih kurang yaitu 5 orang (8,3%). Hasil uji statistik Wilcoxon yangmenunjukkan nilai signifikan p = 0,000 dan dapat dilihat adanya perubahan padapengetahuan remaja tentang Kesehatan reproduksi sebelum dan sesudah dilakuakanPendidikan Kesehatan reproduksi remaja.Kesimpulan. Ada pengaruh yang signifikan antara pendidikan kesehatan terhadappengetahuan remaja sebelum dan sesudah dilakukannya pendidikan kesehatan tentangkesehatan reproduksi
PENGARUH PENGETAHUAN, SIKAP DAN PELATIHAN PERAWAT TERHADAP KESIAPSIAGAAN BENCANA BANJIR DI RUMAH SAKIT STELLA MARIS MAKASSAR
Authors: Tri Wahyudi  , Maulia Aqila Mufidah , Ardianti Anwar  , Hastuti
Published: November 2024

Perawat memiliki peranan penting dalam program kesiapsiagaan bencana. Pengetahuan, keterampilan dan kemampuan perawat dapat memberikan kontribusi yang baik pada tahap respon bencana. Salah satu peran perawat pada tahap respon bencana yaitu memberikan perawatan pada individu maupun komunitas di layanan rumah sakit. Tujuan penelitan, untuk mengetahui pengaruh Pengetahuan, Sikap, Dan Pelatihan Perawat Terhadap Kesiapsiagaan Bencana Banjir Di Rumah Sakit Stella Maris Makassar. Metode, yang digunakan pada penelitian ini adalah jenis penelitian kuantitatif dengan menggunakan pendekatan cross sectional study. Penelitian ini dilakukan dengan jumlah sampel sebanyak 153 responden. Metode pengumpulan data yang digunakan dalam penelitian ini adalah kuesioner dengan teknik analisis univariat, analisis bivariat dengan uji chi-square, dan analisis multivariat dengan regresi logistik. Hasil peneitian menunjukkan bahwa tidak terdapat pengaruh signifikan antara pengetahuan terhadap kesiapsiagaan bencana banjir (p=0.143), sedangkan sikap (p=0.004) dan pelatihan (p=0.000) memiliki pengaruh terhadap kesiapsiagaan bencana banjir di Rumah Sakit Stella Maris Makassar. Kesimpulan variabel yang paling berpengaruh terhadap kesiapsiagaan bencana banjir adalah variabel pelatihan. Saran, Diharapkan bagi pihak Rumah Sakit Stella Maris Makassar untuk lebih meningkatkan pengetahuan dan kemampuan perawat terhadap kesiapsiagaan bencana banjir serta meningkatkan sikap setiap perawat terhadap tindakan kesiapsiagaan bencana banjir.
Reformsrichtung des allgemeinen Gesetzes über die öffentliche Verwaltung
Authors:   Korean Administrative Law Association, Kang Hyun Ho
Published: November 2024

Im Hinblick auf die Änderungsrichtung des allgemeinen Gesetzes über die öffentliche Verwaltung(AGÖV) wurde es mit den geänderten Bestimmungen und Änderungsvorschlägen befasst. Durch den kontinuierlichen Versuch, Änderungen am AGÖV auf Mikroebene vorzunehmen, wurde es die Gesamtvollständigkeit des AGÖV verbessert. In diesem Beitrag ist es in Bezug auf den Namen des AGÖV erforderlich, ihm eine Wirkung zu verleihen, die der Konnotation des Wortes Grundgesetz entspricht. Im Verwaltugnsrecht ist eine gesetzliche Hierarchie erforderlich, und insbesondere das Verwaltungsrecht besteht im Gegensatz zu anderen Rechtsgebieten aus mehr als 1.000 Gesetzen, sodass in diesem Bereich eine Hierarchie zwischen den Gesetzen erforderlich ist. Aus der Vogelperspektive auf das AGÖV sollen zu den wesentlichen Inhalten des AGÖV Zweck und Grundprinzipien der Verwaltung, Verwaltungssubjekte und Verwaltugnsgegner, Verwaltungsverfahren und Verwaltungshandlungen sowie Verwaltungsstreitigkeiten in Bezug auf Rechtsinhalte gehören das AGÖV.
Im Hinblick auf den Zweck der Verwaltung sollten der allgemeine Inhalt des öffentlichen Interesses und bestimmte zu berücksichtigende Faktoren präzisiert werden, und als allgemeine Grundsätze des Verwaltungsrechts besteht die Notwendigkeit, die folgenden Prinzipien neu aufzunehmen, den Grundsatz des ordnungsgemäßen Verfahrens, den Grundsatz der Selbstverbindung der Verwaltung und die Grundprinzipien des öffentlichen Dienstes. Im Hinblick auf die Verwaltungsbehörde werden nähere Regelungen für öffentliche Organisationen gefordert, wobei auch Dritte mit Interessen als Gegenparteien der Verwaltung berücksichtigt werden müssen. Im Verwaltungsverfahren muss interessierten Dritten die Möglichkeit gegeben werden, an Verwaltungsverfahren teilzunehmen. Im Hinblick auf Verwaltungshandlungen wie Verwaltungsverordnungen bzw. Verwaltungsvorschriften, Verwaltungsplänen, Verwaltungsakten, Verträgen des öffentlichen Rechts, Realakten, Mitteln zur Sicherung der Leistungserfüllung und Staatshaftung ist es erforderlich, noch konkrete Regelungen zu treffen.
In Bezug auf Verwaltungsstreitigkeiten besteht die Notwendigkeit, Systeme wie Einsprüche und Widerspruchsverfahren zu vereinheitlichen, und in Verwaltungsprozessen besteht auch die Notwendigkeit, eine einstweilige Anordnung und eine Verpflichtungsklage einzuführen.
KOMUNIKASI ANTARPRIBADI ANTARA MENTOR DAN MENTEE DALAM MEMBANGUN MOTIVASI BELAJAR
Authors: Beka Yunias Lopes , Andung Petrus Ana , Nafie Juan A. , Seran Herman Elfridus
Published: November 2024

Penelitian ini didasarkan oleh realita dimana adanya program unik yang dilakukan oleh SMA Kristen Pandhega Jaya yang tidak dilakukan oleh instansi pendidikan yang lagi di wilayah yang sama. Penelitian ini berfokus pada kegiatan komunikasi antarpribadi.Adapun judul yang diangkat pada penelitian ini adalah komunikasi antar pribadi mentor dan mentee dalam membangun motivasi belajar (Studi Kasus di SMA Kristen Pandhega Jaya) yang didasari akan kebutuhan remaja. Penelitian ini memiliki rumusan masalah yang diambil adalah pola komunikasi antarpribadi mentor dan mentee dan korelasi kegiatan komunikasi antarpribadi tersebut dengan motivasi belajar para mentor dan mentee. metode penelitian menggunakan metode intrumental case studyi. Analisis data pada penelitian ini adalah tahap pengumpulan data, reduksi data, penyajian data, verifikasi dan kesimpulan yang sederhananya dilakukan dengan melakukan deskripsi langsung. Hasil dari penelitian ini menunjukan bahwa pola komunikasi yang dibangun dan terjadi di SMA Kristen Pandhega Jaya adalah Pola komunikasi yang kompleks karena semua pola komunikasi dapat terjadi di sekolah ini, yang sederhananya terbentuk dari berbagai kondisi waktu tertentu. Semua pola tersebut adalah Pola Linear (Komunikasi Satu Arah), Pola Interaktif (Komunikasi Dua Arah) dan Komunikasi Transaksional. Komunikasi ini dapat terbentuk tergantung pada proses pendekatan yang terjadi sebelumnya Sedangkan komunikasi mentor dan mentee dalam membangun motivasi belajar secara tidak langsung terbentuk dari kegiatan asramayang dilakukan di sekolah tersebut dan juga kegiatan komunikasi yang terjalin antara mentor dan mentee. Semakin dekat hubungan yang tercipta antara mentor dan mentee maka akan berdampakpada meningkatnya motivasi belajar para mentee.
Studi Etnografi Komunikasi Ritual Adat Tiba Meka Pada Masyarakat Wae Rebo Kecamatan Satar Mese Barat Kabupaten Manggarai
Authors: Lestari Stenyke Claudia Ayu , Liliweri Aloysius , Nara Maria Yulita
Published: November 2024

Dilatar belakangi dengan aktivitas komunikasi ritual adat tiba meka dengan tujuan untuk mengetahui aktivitas komunikasi ritual adat tiba meka pada masyrakat wae rebo kecamatan satar mese barat kabupaten manggarai. Metode yang digunakan dalam penelitian ini menggunakan penelitian kualitatif dengan pendekatan metode etnografi komunikasi Dell Hymes, teknik pengumpulan data yang dipakai menggunakan  data primer  melalui observasi, wawancara, dan dokumentasi, sedangkan  teknik analisis data menggunakan  reduksi data, penyajian data, dan  penarikan  kesimpulan/verifikasi. Adapun informan dari penelitian ini ada 7 orang yakni tetua adat (1 orang), serta masyarakat kampung yang menjadi bagian dalam  upacara tersebut (4 orang), wisatawan (2 orang) dan tour guide (1 orang). Hasil dari penelitian ini menunjukkan aktivitas komunikasi dalm ritual adat tiba pada masyarakat wae rebo melalui Situasi komunikasi yaitu merujuk pada konteks waktu, tempat, suasana yang terjadi selama proses ritual adat tiba meka. Situasi yang terjalin ada dua yaitu situasi formal dan informal. Peristiwa komunikasi yang terjalin pada saat tiba meka sangat memadai yakni meliputi banyak hal sesuai dengan situasi dan konteks yang terjadi, partisipan yang terlibat, latar belakang terjadinya komunikasi baik tempat maupun waktu, serta norma yang berlaku. Tindakan komunikasi yang terjalin pada saat tiba meka di Wae Rebo baik secara verbal maupun nonverbal berupa nasehat, saran, larangan sangat baik.
Natoni Takanab Sebagai Komunikasi Ritual
Authors: Abi Graciana , Manafe Yermia Djefri , Tuhana Veki Edizon
Published: November 2024

Natoni takanab adalah salah satu ritual yang masih dipraktekkan masyarakat suku dawan hingga kini. Ritual natoni takanab merupakan ritual yang dilakukan dengan menuturkan kata-kata dalam bahasa daerah (bahasa dawan) atau uab meto dalam upacara-upacara tertentu. Komunikasi ritual ini sudah menjadi salah satu tradisi yang diturunkan dari leluhur bagi suku dawan. Penelitian ini bertujuan untuk mendeskripsikan peristiwa komunikasi ritual natoni takanab dan pola komunikasi ritual natoni takanab di desa Sainoni Kecamatan Bikomi Utara Kabupaten Timor Tengah Utara. Penelitian ini menggunakan metode kualitatif etnografi komunikasi. Berdasarkan hasil penelitian menunjukkan bahwa peristiwa komunikasi ritual natoni takanab dapat diidentifikasikan melalui komponen komunikasi. Komponen-komponen etnografi komunikai sebagai berikut: setting atau latar komunikasi, partisipan, tujuan, isi pesan, bentuk isi pesan, kaidah interaksi, norma-norma interpretasi, gendre atau tipe peristiwa komunikastif, topik atau focus referensi, dan  urutan tindakan. Pola komunikasi dalam ritual natoni takanab dapat dipahami melalui isi dari natoni takanab yang disampaikan atonis dan nahe’en berupa kata sapaan dan sembah serta permohonan dan harapan. Komunikasi yang disampaikan berupa komunikasi verbal maupun non verbal. Komunikasi verbal dalam ritual natoni takanab adalah bahasa dawan yang dapat disampaikan secara langsung melalui penuturan natoni takanab, sedangkan komunikasi non verbal dapat dilihat bukan melalui bahasa lisan, melainkan isyarat dengan anggota tubuh antara lain mata, kepala, bibir, dan tangan.
The use of pottery in design treatments for the manufacture of water bottles
Authors: Shanshal Wesam
Published: November 2024

Design treatments play a major role in improving the quality of water when introducing pottery into its manufacture by using pottery treatment methods. Technological developments New techniques have emerged for the manufacture of water bottles, so the employment of pottery in the design treatments for this product crystallizes in a number of aspects, including aesthetic and others represented by environmental sustainability when making water bottles from it, as well as some design treatments according to the requirements of the current era represented in the ease of transportation for water bottles, based on the Therefore, the current research aimed to reveal the design treatments for water bottles using pottery in their manufacture, so in order to verify this goal, the researcher developed a mechanism for design treatments that resulted in some conclusions, the most important of which are: - Water consumption is daily and the need to take care of water bottles. - Plastic bottles are expensive and harmful to the environment.
CAUSAL FACTORS IN RFID TECHNOLOGY UTILIZATION INFLUENCING BUSINESS SUPPLY CHAIN MANAGEMENT EFFICIENCY THROUGH LOGISTICS MANAGEMENT PROCESS A CASE STUDY OF FROZEN FOOD INDUSTRY IN THAILAND
Authors: Srisawat Jakraphun
Published: November 2024

The objective of this research was to study the impact on supply chain efficiency. RFID technology utilization was an independent variable. Logistics management was an intermediary variable, while supply chain management efficiency was the dependent variable. Samples consisted of 315 medium- and large-sized IT executives or professionals in the frozen food industry selected by objective stratified sampling. Data were analyzed using structural equation modeling (SEM), which applied model structure in hypothetical models testing. Results indicated that the model was proportional where all the regression assumptions were accepted with p value < 0.05. The results of the consistency and harmony checked were consistent with the empirical data and the subcomponents of the structural model, with the value /df. = 2.516, GFI = 0.942, AGFI = 0.899, RMR = 0.60, RMSEA = 0.69, NFI = 0.975, CFI = 0.984 (p-value < 0.01). It was found that RFID technology utilization had no direct impact on the efficiency of supply chain however, indirect effects were also shown in logistics management. It was stated that RFID technology should be utilized in the organizations with proper logistics management.
Investigating antimicrobial resistance with EMBL-EBI resources: A practical introduction
Authors: Dyball Xena
Published: November 2024

Antimicrobial resistance (AMR) is one of the most pressing threats to global health, challenging our ability to treat infectious diseases effectively. This tutorial delves into the key concepts surrounding AMR and introduces data resources and tools to support research in this field.
NIST Conference Papers Fiscal Year 2024
Authors: NIST Gaithersburg MD
Published: November 2024

This Special Publication represents the work of researchers at professional conferences, as
reported by NIST employees in Fiscal Year 2024 (October 1, 2023–September 30, 2024).
Diseño de un sistema de monitoreo de la producción y control de tiempos muertos
Authors: Acevedo Gallardo Pedro , De La Riva Jorge , María Reyes Rosa
Published: November 2024

Este artículo presenta el desarrollo de un software para la captura de datos de producción, calidad y mantenimiento el cual permita tener los datos de manera inmediata para la toma de decisiones de manera oportuna y cuando sea requerido sin depender de los departamentos para la entrega de información. La ventaja principal en que el sistema mantiene actualizado una base de datos en tiempo real de producción, mantenimiento y calidad. Así mismo, genera gráficas de manera inmediata para visualizar el comportamiento de la producción.
Disminución de defectos por soldadura inestable en calentadores de agua
Authors: García Castellanos Humberto , Márquez Márquez Cynthia , Herrera Ríos Ericka Berenice , Loera Castro Adrián Francisco
Published: November 2024

Se tiene una corporación a nivel mundial dedicada a la manufactura de los principales dispositivos sobre el tratamiento del agua, cuenta con plantas de manufactura de calentadores de agua en India, China, Estados Unidos, Brasil y México, estando a la vanguardia de la más alta tecnología en dispositivos para el tratamiento del agua.
En la actualidad el sistema de manufactura de la empresa, se enfoca en las necesidades del cliente, se pretende mejorar el proceso en el área de fabricación de productos de agua.
Una de las mayores causas de que se manifieste un defecto del código 8, es la aplicación de vidrio en el cilindro en las máquinas, debido a una variación en el cepillado y la limpieza en la parte inferior del cilindro.
Edythe London: Translating knowledge from molecular and functional imaging studies to new pharmacological and brain stimulation treatments for addiction
Authors: London Edythe
Published: November 2024

Edythe London, Ph.D., is a distinguished professor-in-residence in the Departments of Psychiatry and Pharmacology at the University of California, Los Angeles (UCLA), where she holds the Thomas P. and Katherine K. Pike Chair in Addiction Studies. She chaired (2010–2014) and later co-chaired (2015–2022) UCLA's Integrative Center for Addictions (2010–2014). Before coming to UCLA, she was acting chief of the Neuroscience Branch and Chief of the Neuropharmacology Laboratory in the Intramural Research Program of the National Institute on Drug Abuse, USA. There, she established and was the Director of NIDA's Brain Imaging Research Center (1992–1999). In her engagement with the Genomic Press Interview, Professor London offered insights into her life and distinguished career, enriching the series with her unique perspectives.
Michele T. Pato: Nature and nurture are essential to living the fullest and most enjoyable life; it is never just about our genes but what you do with them and what you bring to the table
Authors: Pato Michele T.
Published: November 2024

Michele T. Pato, MD, is Professor of Psychiatry and Inaugural Director of the Rutgers Center for Psychiatric Health and Genomics. Dr. Pato's research has been focused on increasing the representation of minority populations in large-scale genomic studies and through that process further contributing to the elucidation of the genomics of common and complex psychiatric disorders, such as schizophrenia and bipolar disorders. Underrepresented minority groups, particularly those in US-based communities of Latino and African descent, have traditionally not been sufficiently included in genomic studies. Yet, these populations have the most significant disparities in health care and outcomes; they also have the potential to substantially broaden our knowledge of human genetics. Dr. Pato has a lifelong history of exposing and mentoring trainees towards pathways in research. She is the author of NERVE: A Physician Turned Patient and Her Courageous Recovery from Traumatic Brain Injury, published by Springer in 2023. We are delighted to present to our audience insights into Dr. Pato's life and professional journey.
Charlotte Steenblock: How does stress impact stem cells of the hypothalamic-pituitary-adrenal axis?
Authors: Steenblock Charlotte
Published: November 2024

Dr. Charlotte Steenblock is a group leader at the Department of Internal Medicine at the Carl Gustav Carus University Clinic in Dresden, Germany. Her research focuses on stem and progenitor cells of the hypothalamic-pituitary-adrenal axis. Using animal models of physical and metabolic stress, she investigates the role of different kinds of stress on the proliferation, differentiation, and migration of these stem and progenitor cells. Furthermore, she aims to differentiate pluripotent stem cells into steroid-producing adrenal cortex-like cells that can ultimately serve as cell replacement therapies for patients suffering from adrenal insufficiency or congenital adrenal hyperplasia. Lastly, Dr. Steenblock researches the connections between metabolic and endocrine diseases and infectious diseases, including post-acute infectious syndromes such as long-COVID. Dr. Steenblock is happy to answer the Genomic Press Interview, providing our readers with reflections on her life and career.
Daniel H. Wolf: Understanding motivation impairment from clinical, behavioral, and neurobiological perspectives to pave the way for better treatments
Authors: Wolf Daniel
Published: November 2024

Dr. Daniel Wolf grew up in Los Angeles, completed his BA at Harvard College, MD-PhD at Yale University, psychiatry residency at MGH-McLean, and neuropsychiatry fellowship at UPenn. He is an Associate Professor of Psychiatry at UPenn's Perelman School of Medicine. As head of the Laboratory for Motivation in Psychiatry, Dr. Wolf uses functional neuroimaging to study the neural mechanisms of amotivation and other symptom dimensions in psychosis and at-risk states, aiming to develop novel assessment biomarkers for early-stage drug development. Dr. Wolf also provides outpatient care to individuals with psychosis while supervising clinical trainees. As Director of the Clinical Neurosciences Training Program and Co-Director of the Psychosis T32, he provides seminars and mentoring to medical and graduate students and postdoctoral fellows; he earned the School of Medicine's teaching awards in both Basic Science and Translational Science. He is also an ACNP Fellow and member of the Neuropsychopharmacology editorial board. Dr. Wolf answered the Genomic Press Interview, providing our readers with reflections on his life and career.
Illana Gozes: From the pivotal discovery of activity-dependent neuroprotective protein (ADNP) through its investigational drug davunetide: brain molecular medicine providing hope for autism, schizophrenia, and Alzheimer's disease
Authors: Gozes Illana
Published: November 2024

Professor Illana Gozes, Ph.D., is a faculty member at Tel Aviv University. Formerly holding the Lily and Avraham Gildor Chair for the Investigation of Growth Factors, she now directs the Dr. Diana and Zelma Elton Laboratory for Molecular Neuroendocrinology. A world-renowned neurochemist, Professor Gozes currently serves as the President of the European Society for Neurochemistry and Vice President of Drug Development at ExoNavis Therapeutics Ltd. Her groundbreaking research began in the late 1970s and early 1980s when she discovered multiple tubulin forms within a single neuron. She demonstrated that these forms evolve with brain development, play a crucial role in synapse formation, and can be identified using monoclonal tubulin antibodies. At the forefront of molecular neuroscience in the 1980s, Professor Gozes became the first to clone the gene encoding vasoactive intestinal peptide (VIP), a key regulatory neuropeptide in the brain. Her research revealed increased VIP expression during synapse formation. In her quest to identify proteins activated by VIP and facilitate neuro-glial interaction, the Gozes laboratory discovered and cloned a novel protein: activity-dependent neuroprotective protein (ADNP). Subsequent research established ADNP's essential role in brain formation and function. Through a series of highly cited articles, Professor Gozes demonstrated that ADNP regulates thousands of essential genes during brain development in a sex-dependent manner and associates with an intricate array of vital proteins. She uncovered ADNP's key role in autophagy and schizophrenia, revealed a fundamental shared mechanism in autism involving critical binding of ADNP with SHANK3 and actin, and showed ADNP's regulation of microtubule dynamics and Tau interaction, which protects against tauopathy. Furthermore, she discovered somatic mutations in ADNP and related genes in Alzheimer's disease, paralleling tauopathy. Her pioneering work on ADNP-deficient mouse models predicted the ADNP syndrome, an autistic/intellectual disability syndrome driven by de novo mutations in ADNP and presenting with tauopathy. Professor Gozes took a reductionist approach to discover an active site in ADNP, leading to the development of the investigational drug davunetide (NAP). This compound has shown promise in protecting against ADNP deficiency/mutations in animal models and in clinical trials. It has been tested in women suffering from progressive supranuclear palsy (PSP), a pure tauopathy, and in individuals with prodromal Alzheimer's disease, demonstrating effects in a sex-dependent manner. Further promise was shown in schizophrenia patients, suggesting improvement in real-world problem solving and task performance. We are honored that Professor Gozes has agreed to share her life's journey with our readers in this Genomic Press Interview.
Carlos A. Zarate, Jr.: Using clinical translational neuroscience to develop the next generation of antidepressant treatments that act more rapidly and effectively
Authors: Zarate Carlos A.
Published: November 2024

Carlos A. Zarate, Jr., MD, spearheads transformative research in psychiatry and neuroscience. As a National Institutes of Health (NIH) Distinguished Investigator, he leads the Experimental Therapeutics and Pathophysiology Branch and the Section on the Neurobiology and Treatment of Mood Disorders at the National Institute of Mental Health (NIMH). His additional role as Clinical Professor of Psychiatry and Behavioral Sciences at George Washington University underscores his commitment to research and education. Dr. Zarate's pioneering work focuses on decoding the pathophysiology of treatment-resistant mood disorders and suicide while developing novel therapeutics that are reshaping approaches to patient care. His research integrates cutting-edge techniques from neuropsychopharmacology, electrophysiology, neuropsychology, neuroimaging, and genomics to forge new pathways in treating mood disorders. Perhaps most notably, Dr. Zarate's team has been instrumental in demonstrating that ketamine, an NMDA receptor antagonist, can produce rapid and long-lasting antidepressant and anti-suicidal effects. This discovery has catalyzed a paradigm shift in psychiatry, proving that antidepressant response within hours, not weeks, is achievable. Dr. Zarate's innovative approach extends beyond the lab. He employs a bi-directional translational strategy, seamlessly integrating clinical, behavioral, and imaging technologies with basic science collaborations. This holistic method has led to numerous breakthroughs in mood disorders research, addressing critical issues such as the speed and efficacy of current treatments. His exceptional contributions to the field have earned him numerous accolades, including election to the National Academy of Medicine in 2020. These honors recognize his research excellence, his innovative spirit, and his dedication to mentoring the next generation of scientists. We are privileged to feature Dr. Zarate in this Genomic Press interview. His insights promise to offer our readers a glimpse into the cutting edge of psychiatry and the tangible hope his work brings to millions suffering from mood disorders.
Depression: A malady of the self, arising from stress responses gone awry
Authors: Gold Philip W.
Published: November 2024

Major depression is one of the most significant disorders of our time. It is a heterogeneous, common, and complex disorder of gene–environment interactions, with multiple subtypes, including patients with melancholic or atypical features, that appear to stem from distinct clinical and physiological substrates. Stress is a disruptor of homeostasis and may pathologically extend into depression, particularly when adaptive responses become dysregulated. An integrated treatment approach, combining psychotherapy and pharmacotherapy, should target both the behavioral patterns and physiological underpinnings of depressive disorders.
Maria A. Oquendo: The translational pathway from the elucidation of the biological contributions to suicide risk to the development of interventions aimed at preventing morbidity and mortality
Authors: Oquendo Maria A.
Published: November 2024

Dr. Maria Oquendo is Ruth Meltzer Professor and Chairman of Psychiatry at University of Pennsylvania and Psychiatrist-in-Chief at the Hospital of the University of Pennsylvania. A summa cum laude graduate of Tufts University, she attended College of Physicians and Surgeons, Columbia University and completed residency at Payne Whitney Clinic, New York Hospital, Cornell. She is a member of the National Academy of Medicine, one of the highest honors in medicine. Dr. Oquendo has used Positron Emission Tomography and Magnetic Resonance Imaging to map brain abnormalities in mood disorders and suicidal behavior. Her expertise ranges from psychopharmacology to Global Mental Health. She has over 500 peer-reviewed publications, an H-index 116 and 49,472 citations (Google Scholar). In terms of organizational leadership positions, Dr. Oquendo is Past President of the American Psychiatric Association (APA), the International Academy of Suicide Research, the American College of Neuropsychopharmacology (ACNP), and the American Foundation for Suicide Prevention's Board of Directors. She is Vice President of the College of International Neuropsychopharmacology and has served on the National Institute of Mental Health's Advisory Council. Dr. Oquendo serves on Tufts University's Board of Trustees, serves on its Executive Committee and chairs Tufts’ Academic Affairs Committee. A recipient of multiple awards in the United States, Europe, and South America, most recently, she was honored with the Symonds Award (APA 2017), the APA's Research Award (2018), the Shockley Award (ACNP 2018), and the Glassman Award (Columbia University 2021). Dr. Oquendo has shared some of her thoughts and perspectives on her life and career.
Gustavo Turecki: Three fundamental questions – How does the brain respond to social and emotional experiences? Why does psychological trauma trigger depressive states? What are the mechanisms of antidepressant responses?
Authors: Turecki Gustavo
Published: November 2024

Gustavo Turecki MD PhD FRSC is a clinician scientist whose work focuses on understanding brain molecular changes that occur in major depressive disorder and suicide, as well as molecular processes that explain antidepressant treatment response. Dr. Turecki is Full Professor and Chair of the Department of Psychiatry at McGill University, the Scientific Director and Psychiatrist-in-Chief of the Douglas Institute in Montreal, Canada, where he also heads the Depressive Disorders Program. He has authored over 600 publications, including research articles in leading peer-reviewed journals such as Nature Neuroscience, Nature Medicine, and The Lancet and is among the world's most highly cited scientists according to Clarivate, Web of Science. He has received several national and international awards and sits on several advisory boards. Dr. Turecki graciously offers our audience a glimpse into his personal and professional journey.
Yogesh Dwivedi: Pre-clinical and translational research focusing on gene regulation through epigenetic and epitranscriptomic mechanisms and their implications in mood disorders and suicidal behavior
Authors: Dwivedi Yogesh
Published: November 2024

Dr. Yogesh Dwivedi is the Elesabeth Ridgely Shook Endowed Chair and Professor in the Department of Psychiatry and Behavioral Neurobiology at the University of Alabama at Birmingham (UAB). He joined UAB in 2013 after working at the University of Illinois at Chicago for about 20 years, where he rose to tenured Professor. He is the Vice Chair for Faculty Affairs and Faculty Development, Co-Director of the UAB Depression and Suicide Center, Director of Translational Research of the UAB Mood Disorder Program, and the Director of the Alabama Brain Bank. He has published over 160 papers in peer-reviewed journals and serves on the editorial board of several scientific journals. He leads multiple National Institute of Mental Health-funded studies and has also edited a book entitled The Neurobiological Basis of Suicide. The recipient of several national and international awards, Dr. Dwivedi is a member of the Scientific Council of the American Foundation for Suicide Prevention and a Fellow of the American College of Neuropsychopharmacology (ACNP), International College of Neuropsychopharmacology (CINP), and International Neuropsychiatric Association. His research broadly elucidates the molecular and cellular mechanisms associated with early-life stress, mood disorders, and suicidal behavior by integrating basic and clinical neuroscience. More specifically, his studies focus on gene regulation through epigenetic, epitranscriptomic, and non-coding RNAs and whether these mechanisms play a role in mood regulation and suicidal behavior. He is also working on translating these findings into biomarkers for depression, suicidality, and treatment response. Dr. Yogesh Dwivedi kindly agreed to engage in the Genomic Press Interview, sharing his distinctive blend of personal and professional narratives.
Recent findings and future directions for the intersection of genetic and environmental contributions to schizophrenia
Authors: Robinson Natassia , Bergen Sarah E.
Published: November 2024

It is well established that both genetic and environmental factors contribute to risk for schizophrenia (SCZ), and much progress has been made in identifying the specific factors conferring risk. However, the nature and extent of interactions between them has long been a topic of debate. Both the data and methods available to address this have evolved rapidly, enabling new prospects for identifying gene–environment interactions in SCZ. To date, there is limited evidence of strong gene–environment interactions, with environmental factors, molecular genetic risk, and family history simultaneously contributing to risk of SCZ. Still, there are several enduring challenges, some of which can likely be addressed with new tools, methods, and approaches for investigating gene–environment interplay. Consequently, advancements in this field will enhance our capacity to identify individuals most vulnerable to specific environmental exposures, which is pivotal for targeted prevention and intervention.
The association between trace amine-associated receptor 1 (TAAR1) genetic mutations and neuropsychiatric disorders
Authors: Shajan Britto , Bastiampillai Tarun , Nair Pramod C.
Published: November 2024

Trace amine-associated receptor 1 (TAAR1) is an emerging drug target for the treatment of neuropsychiatric conditions. Several TAAR1-targeted therapeutics are currently in clinical and preclinical development. Emerging studies highlight links between TAAR1 single-nucleotide variants/polymorphisms and neuropsychiatric disorders. An improved understanding of TAAR1 genetic variants and their functional impact will inform the potential role of the TAAR1 system in the pathophysiology of neuropsychiatric conditions and for better therapeutic dosing. This viewpoint examines clinical and molecular studies involving TAAR1 genetic variants and their association with neuropsychiatric disorders.
Psilocybin-assisted psychotherapy: Advancements, challenges, and future directions for treating resistant depression
Authors: de Melo Rodrigues Rodolfo Myronn
Published: November 2024

Depression is a global public health challenge that represents the world's largest cause of disability, especially in the context of traditional treatments. One potential solution being explored is psilocybin assisted psychotherapy (PAP) which shows promise for treating depression. A recent study by Rosenblat et al. explores the use of psilocybin in clinical mental care with promising results (1).
Impacto de la Mala Nutrición en el Rendimiento Académico de los Estudiantes del Tercer Año de la Escuela de Educación Básica 18 de Noviembre
Authors: Morocho Morocho Carmen del Cisne , Barrera Remachi Jheny Maribel , Calle Sánchez Edgar Ider , Intriago Mera Jenny Corina , Luna Méndez María Elizabeth
Published: November 2024

El presente estudio de investigación tiene como objetivo analizar el impacto de la mala nutrición en el rendimiento académico de los estudiantes del tercer año de la escuela de educación básica “18 de noviembre”, paralelo “A”. Se empleó una metodología mixta, combinando enfoques cuantitativos y cualitativos, que incluyó encuestas y entrevistas dirigidas a docentes y padres de familia para conocer sus perspectivas sobre la relación entre una mala nutrición y el rendimiento académico.  El análisis de las entrevistas determinó que los docentes tienen una comprensión clara de cómo influye la nutrición en el rendimiento académico como también en el desarrollo cognitivo general; en contraste una parte significativa de los padres de familia no presta suficiente atención a la orientación nutricional y subestima la influencia de la alimentación en el rendimiento académico de sus hijos, otros padres, se esfuerzan por fomentar una adecuada nutrición, pero sus esfuerzos no siempre resultan positivos debido a la falta de recursos económicos, la falta de educación nutricional adecuada, y la creencia errónea de que la comida no afecta significativamente el rendimiento académico. En base a los resultados del estudio, se concluye que una adecuada nutrición permite mejorar el rendimiento académico en los y las estudiantes
Research on the Application of AIGC in the Film Industry
Authors: Gao Mingda , Leong Wai Yie
Published: November 2024

This paper explores the feasibility of applying artificial intelligence generated content (AIGC)
technology in the film industry, analyzes its potential to replace certain positions in the film
industry, and explores how to integrate AIGC into different aspects of film production such as
script writing, video production, and audio processing through experimental creation. Comparative
research and experimental methods are used to explore the feasibility of applying AIGC in the film
industry at this stage. The more mature AIGC platforms such as ChatGPT 4.0, Stability AI,
Midjourney, and Suno V3.5 are used for research to optimize the film production process and
provide some reference for other researchers. The findings suggest that AIGC could redefine
industry standards and democratize the filmmaking process, enabling more creators to access
sophisticated tools and produce high-quality content. This paper ultimately provides a roadmap
for the strategic adoption of AIGC in filmmaking, outlining best practices and future research
directions for a sustainable and creative AI-powered film industry.
Twenty Points to Be Considered in the Interpretation of a Sandplay
Authors: Kalff Martin
Published: November 2024

A request for guidelines in interpretation of sandplay scenes by American students prompted this article. These considerations are based on the suggestion that Sandplay allows for the expression of preverbal consciousness or lunar consciousness. Symbols are discriminated from signs. Interpretation by the therapist to the client is discouraged, in order to not limit free, creative expression. Twenty points are given for the understanding of a client's sandplay process. The author concludes by restating the limitation of words in communicating about a specific sandtray.
Afterthoughts on the Masculine
Authors: Weller Barbara
Published: November 2024

This article is a reflection of the author on a variety of questions which emerged for her in preparation for her presentation at the Northern California Sandplay Society's "On the Masculine" Conference in March, 1994. The questions that emerged prompted more awareness for the author of her masculine side and the dark feminine, and then led to more questions. The author concludes with a statement by Rainer Maria Rilke, who wrote, "Live the questions now. Perhaps, you will gradually, without noticing it, live along some distant day into the answers."
Men's Violence in Sandplay
Authors: Rise Claudio
Published: November 2024

This article discusses the question that men bring to therapy, which has to do with being a man, what is masculine energy and how to use it. Through what the author describes as initiation, a man becomes conscious of this masculine energy. The separation from mother, prompts the awareness of the interior center holding violence. In transforming it, there can be an attitude of reverence and awe, sacrificing it. The sandplay process allows for recognition of and mastery over the violence. The author writes of the mark of Cain, the mark of the promise of violence. The mark confirms that in male development the struggle with violence will prompt responsible individuality, passion, power and grief.
ANALISIS FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP KESADARAN KEWAJIBAN PERPAJAKAN SEKTOR USAHA MIKRO, KECIL DAN MENENGAH (UMKM) DI KPP PRATAMA BUKITTINGGI
Authors: Muhammad Rifan Salim  , Eka Rosalina  , Muhammad Rafi
Published: November 2024

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi kesadaran akan kewajiban perpajakan pada sektor usaha mikro, kecil, dan menengah (UMKM) yang terdaftar di KPP Pratama Kota Bukittinggi. Faktor-faktor yang diteliti mencakup variabel pengetahuan wajib pajak, tingkat penghasilan wajib pajak, kemudahan dalam sistem pembayaran pajak, dan sanksi pajak. Sampel penelitian ini terdiri dari 377 responden wajib pajak UMKM yang terdaftar di KPP Pratama Kota Bukittinggi. Hasil penelitian menunjukkan bahwa pengetahuan wajib pajak, tingkat penghasilan, kemudahan pembayaran pajak, dan sanksi pajak memiliki pengaruh signifikan terhadap kesadaran kewajiban perpajakan pada sektor UMKM di daerah tersebut. Nilai t-statistik untuk masing-masing variabel, yaitu pengetahuan wajib pajak, tingkat penghasilan, kemudahan pembayaran, dan sanksi pajak, berturut-turut adalah 7,586; 7,699; 4,606; dan 4,900. Nilai-nilai ini mengindikasikan bahwa setiap variabel independen memiliki pengaruh positif dan signifikan terhadap variabel dependen dalam penelitian ini.
Tıp Fakültesi üçüncü sınıf öğrencilerinin “Kötü Haber Verme” deneyimleri ve Simüle hasta etkileşimi geribildirimleri
Authors: Çınar Tanrıverdi Esra , Gürsoy Güven Pınar , Daylan Koçkaya Pınar , Özkurt Zülal , Çayır Yasemin , Nas Mehmet Akif
Published: November 2024

Amaç: Hasta ve/veya yakınlarına kötü bir haberi vermek hekimler için zor görevlerden biridir ve bu görev iletişim becerisi gerektirir. İletişim becerileri tıp fakültelerinin mezun yeterlikleri arasındadır. Bu çalışmada, tıp öğrencilerinin kötü haber verme konusundaki algıları ve simüle hasta görüşmeleri sonrası geri bildirimlerinin değerlendirilmesi amaçlanmıştır.
Yöntemler: Araştırma karma modelde olup, nicel ve nitel araştırma desenini içermektedir. 2021-2022 öğretim yılında, “kötü haber verme becerisi” dersine katılan ve simüle hasta ile görüşme yapan gönüllü üçüncü sınıf öğrencileri ile yürütülmüş, veri toplama aracı olarak, açık uçlu bir sorunun da yer aldığı yapılandırılmış bir form kullanılmıştır. Veriler SPSS 25 istatistik paket programında analiz edilmiştir.
Bulgular: Çalışmaya gönüllü olarak katılan 330 tıp öğrencisine ait veri değerlendirilmiştir. Katılımcıların yaş ortalaması 21,7±2,86 (19-50) ve %52,7’si (n=175) kadındır. Öğrencilerin %87’si (n= 289) kötü haberin hastaya söylenmesi gerektiğini ve %94,6’sı (n=314) bu konuda eğitim alınması gerektiğini düşünmektedir. Eğitim sonrası öğrencilerin %59,9’u (n=199) kötü haberi uygun şekilde verebileceğini belirtmiştir. Kötü haber verebilme ile ilgili öz yeterlilik algıları açısından cinsiyetler arasında anlamlı fark saptanmamıştır.
Sonuç: Öğrenciler kötü haber vermenin hem alıcı hem verici taraf için zor bir deneyim olduğunu, görüşmede en çok empatinin önemini fark ettiklerini belirtmişlerdir.