bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical modeling of the rotary furnace operations for the production of clinker
Authors: Hernández Yusdel Díaz , Figueredo Marcos Batista , Néri Thais de Souza , Silva Alexandre do Nascimento
Published: December 2023

This paper presents a comprehensive system of mathematical models to describe, simulate, and optimize the operational and energetic aspects of rotary furnaces within the cement industry. To achieve this, we delve into the interaction between the furnace and other aggregates within the plant. We define the key variables governing the furnace’s operation through a meticulous analysis. Leveraging the power of genetic algorithms, we successfully validate the model’s performance under static and dynamic operational conditions. A pivotal aspect of our approach involves considering the behavior of combustion gases as analogous to a piston flow system. This consideration enhances our understanding of the complex processes occurring within the furnace. Furthermore, we establish shutdown criteria based on predetermined values obtained from the Case study facility: TR (Total Runtime) of 47 minutes, GT (Gas Temperature) at 97 percent, and ℵ (Agitation Speed) at 35 percent. These predefined values align with the desired outcomes of our objective function (Z). Through integrating and implementing our findings, a promising avenue emerges for improving the final product’s fuel consumption rate and quality. By concurrently addressing the plants and furnaces efficiency indicators, we set the stage for a more sustainable and productive operation in the cement industry.
Toponimia de Muros
Authors: Blanco Quintela Alfonso
Published: December 2023

Alfonso Blanco Quintela é profesor de latín e grego no IES Fontexería de Muros, desde o que vén realizando un amplo labor de divulgación sobre a toponimia do concello. Neste volume, analiza os 105 topónimos da toponimia maior de Muros e sete nomes de lugar pertencentes á toponimia menor. A colección Terra Nomeada da Real Academia Galega e a Asociación Galega de Onomástica ten como obxectivo recompilar e estudar os nomes de lugar dos concellos de Galicia para saber cal é a súa motivación e o seu significado, o que nos fará máis conscientes da relación co noso pasado, de como se conformou a nosa sociedade, de como é a natureza en que habitamos, a súa fauna e as plantas.
Toponimia de Antas de Ulla
Authors: Santiso Arias Andrea
Published: December 2023

Toponimia de Antas de Ulla parte do Traballo de Fin de Grao da lóloga Andrea Santiso Arias, dirixido por Ana I. Boullón Agrelo. A autora é membro da Asociación Galega de Onomástica e forma parte do proxecto de investigación do Instituto da Lingua Galega Toponomasticon Hispaniae. A colección Terra Nomeada da Real Academia Galega e a Asociación Galega de Onomástica ten como obxectivo recompilar e estudar os nomes de lugar dos concellos de Galicia para saber cal é a súa motivación e o seu significado, o que nos fará máis conscientes da relación co noso pasado, de como se conformou a nosa sociedade, de como é a natureza en que habitamos, a súa fauna e as plantas.
IT-ІНСТРУМЕНТИ В СТРАТЕГІЧНОМУ УПРАВЛІННІ ПОТЕНЦІАЛОМ ПІДПРИЄМСТВА
Authors: Чопко Н.С. , Соболта В.Ю.
Published: December 2023

У статті досліджуються проблеми стратегічного управління потенціалом підприємства в умовах сучасності та застосування передових ІТ-інструментів. Розвиток ІТ технологій має значний вплив на усі сфери життя, у тому числі у галузях повʼязаних з управлінням потенціалом підприємства. Саме тому глибокий аналіз впливу новітніх технологій на оптимізацію управлінських процесів і стимулювання стратегічного розвитку підприємства робить статтю актуальною у сучасних реаліях. Досліджено, як цифрові інструменти впливають на різні аспекти бізнесу, зокрема на підвищення ефективності управління та конкурентоспроможності компанії. Додатково, у статті звертається увага на ідентифікацію потенційних викликів та визначення можливостей, що виникають при використанні цифрових інструментів. Враховуючи швидкі темпи технологічного розвитку, цей аспект стає ключовим для підприємств, орієнтованих на інновації та стабільний розвиток в динамічному бізнес-середовищі.
Metoda bisekcije primjenom Maxima računalne aplikacije
Authors: Banov Reni , Benković Martina , Orlić Bachler Mandi
Published: December 2023

Tijekom izvođenja nastave iz matematičkih kolegija na stručnim studijima pokazuje se korisnim primijeniti računalne aplikacije za potrebe detaljne ilustracije numeričkih metoda. Posebice, sa stanovišta boljeg razumijevanja izvođenja numeričkih algoritama korisno je studentima prezentirati rezultate međukoraka u izvođenju algoritma na računalu. Na Tehničkom veleučilištu opredijelili smo se za primjenu računalne aplikacije Maxima, te je ona uključena u redovni program preddiplomskog stručnog studija graditeljstva. U ovom radu izložena je numerička metoda za nalaženje nultočaka neprekidne funkcije, metoda bisekcije, te je prikazan pripadni algoritam izveden u računalnoj aplikaciji Maxima.
Razvijanje plitkih neuronskih mreža pomoću MATLAB-a. Primjena na rješavanje parametarski ovisnih diferencijalnih jednadžbi
Authors: Bakoč Paulina , Lazar Martin
Published: December 2023

Cilj ovog rada je objasniti kako se stvara, razvija i koristi plitka neuronska mreža korištenjem programskog alata MATLAB. Kao testni primjer uzet je problem predviđanja izlaznih vrijednosti rješenja parametarski ovisne diferencijalne jednadžbe prvog reda. Dobiveni rezultati potvrđuju sposobnost neuronske mreže da brzo i pouzdano reproducira tražene vrijednosti bez potrebe rješavanja same jednadžbe.
IMPROVE THE SENSORY AND MOTOR ABILITIS OF CHILDREN USING EDUCATIONAL GAMES AGE 5-7 YEARS IN PRIMARY SCHOOL 24 RAMBUTAN
Authors: Agustian Berry , Mawardah Mutia
Published: December 2023

This service was carried out at the State Elementary School 24 Rambutan, Durian Gadis Village, Banyuasin district. Data collection techniques using observation, documentation, action, and reflection are used to collect data. The child's learning results and the analysis of the sensory and motor skills of the child in learning with the learning of numbers and letters through the combination of educational learning models and play models are carried out to know the speed of development by observing the child after being given home tasks in accordance with the rules that have been determined. The results showed an improvement in fine motor, auditory, visual, and gross motor skills in which the child’s activity meets the criteria of being highly active and the development of the sensory motor aspects of the child reaches the expected indicators of success. The results of this dedication show that the child's development in the State Elementary School 24 Village Durian Gadis Prefecture district of Banyuasin has been optimal.
ASSISTANCE FOR MICRO SMALL, AND MEDIUM ENTERPRISES THROUGH LEARNING HOW TO MAKE FINANCIAL REPORTS AND TAX AWARENESS IN MADIDIR WERU VILLAGE
Authors: Evinita Lenny Leorina , Pandowo Adithya , Purba Pebisitona , Paoki Rouna
Published: December 2023

The purpose of this activity is to provide progress for Micro Small Medium Enterprises actors in proper financial planning and management to improve the income and increase knowledge about taxes. It is found many beginner MSME business people who doesn’t understand how to manage finances. Based on the phenomenon of the problems that occurs and the result of discussion with partners, The method used to improve the performance of MSME actors can carry out proper management of finances by gave training activities how to provide simple financial report and give a knowledge about taxes so the MSME actors in Madidir Weru can compete with the business world.
ANALYSIS OF MUSABAQAH TILAWATIL QUR'AN ACTIVITIES IN INCREASING MOTIVATION FOR MEMORIZING THE QUR'AN IN MADRASAH ALIYAH TAHFIZHIL QUR'AN MEDAN
Authors: Nasution Mawaddah , Addni Annas Nurjannati
Published: December 2023

In memorizing the Qur'an, motivation is needed, both motivation to add new memorization, motivation to maintain memorization, and discipline motivation to divide time so that the quality and quantity of memorization are maintained properly. However, in reality, many memorizers of the Qur'an still have low motivation, so they have difficulty memorizing the Qur'an. Many want to memorize the Al-Qur'an but are worried that they will not be able to memorize it in the future. Musabaqah Tilawatil Qur'an (MTQ) is an effort to provide motivation to the younger generation to read, memorize and understand the Qur'an. With the existence of Musabaqah Tilawatil Qur'an (MTQ) it becomes a forum to increase motivation to memorize the Al-Qur'an and as a means for memorizers of the Al-Qur'an to test the quality of their memorization. The rapid development of MTQ in Indonesia is a manifestation of people's love for the Qur'an. MHQ in this case is considered to be able to motivate memorizing the Al-Qur'an, so that it is hoped that the students at Madrasah Aliyah Tahfizhil Qur'an Medan have good memorization skills and motivation to memorize. From this research it can be concluded that it can be concluded that the students who memorize the Al-Qur'an at Madrasah Aliyah Tahfizhil Qur'an Medan have their own way of memorizing the Al-Qur'an. This can be seen from their ability to apply self-motivation, self-management and preparation for MTQ.
EMPOWERING NATURAL RESOURCES AND HUMAN RESOURCES IN THE SEBUMI PROJECT TO PREVENT COVID-19
Authors: Desmawati Desmawati , Agustina Agustina , Samaria Dora , Ritanti Ritanti , Ayu Marcelina Lina , Sucika Dara , Aprilia Farah , Shahidda Nadia , Nur’aeni Wisudawati Sulistya , Dwi Suciantie Pramesti
Published: December 2023

Although Covid-19 has been reported as zero, however, people are always vigilant in dealing with Covid-19. Empower of community is needed to prevent and adapt to Covid-19. These natural and community service activities aim to increase prevention efforts of COVID-19 with clean water source projects. The methods used are socialization, or refreshing content related to COVID-19 to cadres and as well as the residents, then advocacy is carried out on RT, RW, and village heads regarding the COVID-19 prevention program, The output of this program is the availability of clean water source In Baduy as a facility for hand washing, cooking, etc., The results of the study reported that there was an increase in enthusiasm for carrying out a clean healthy lifestyle after socialization to prevent covid-19 as much as 81.8% (good) and the rest were very good, as well as the establishment of drilled wells as a source of clean water. Qualitatively, the results of this humanitarian project created an atmosphere of sharing among residents with clean water distributed to residents. This is very helpful for residents as an effort to prevent the spread of Covid-19 as a whole. In addition, involving people who influence the community such as religious leaders and influential citizens is also very helpful in supporting each other and reminding each other to always implement health prevention of COVID-19
Formativni aspekti
evaluacije u odgoju i obrazovanju
Authors: Wurzberg Antonija
Published: December 2023

Tematika vrednovanja u odgojno obrazovnom procesu zauzima važno mjesto. Suvremena nastava pretpostavlja holistički pristup praćenju i vrednovanju učeničkih postignuća, a to označava individualiziran pristup svakom učeniku. Individualizacija poučavanja i vrednovanja omogućava učenicima razvoj osobnih potencijala. Prema nacionalnim dokumentima obrazovanje se treba temeljiti na pedagogiji uspjeha, a učenički uspjeh treba mjeriti u odnosu na njihovo početno stanje. Ocjenjivati se treba u suradnji sučenicima što pretpostavlja da učenici postaju aktivni dionici odgojno obrazovnog procesa. Vrednovanje je usmjereno učenju i kao takvo treba omogućiti učeniku kvalitetne povratne informacije utemeljene na dokazima prikupljenim tijekom praćenja. Informacije o napretku učenika koje učitelj stavlja pred učenike i roditelje trebaju biti jasne i lako razumljive svim dionicima ove trijade. Poželjno je učenike poticati na razvoj vještina samovrednovanja čime bi se razvila svijest kod učenika o vlastitim znanjima. Posljedično, izvršit će se utjecaj i na cjeloživotno učenje. U isto vrijeme potrebno je podržavati učenike u stjecanju pozitivne slike o sebi . Poticanjem na promišljanje o svojim kognitivnim procesima učenike se usmjerava na planiranje rada i samostalno donošenje odluka o daljnjim koracima učenja. Prikupljanje informacija o procesu učenja učenika i njihovom trenutnom postignuću te interpretacija tih informacija trebaju biti temelj učitelju za daljnje planiranje nastave. Učeniku te informacije služe za daljnje planiranje učenja. Ovakav oblik vrednovanja označava formativni pristup vrednovanju. Ovaj rad pretpostavlja da formativno vrednovanje kao oblik kontinuiranog praćenja učeničkih postignuća poboljšava razredno ozračje i povezano je sa uspješnim samovrednovanjem učenika . Potom se ističe nužnost primjene formativnog vrednovanja i opisuju se aktuelni oblici vanjskog vrednovanja u hrvatskom školstvu te razmatra povezanost vanjskog vrednovanja sa unutarnjim vrednovanjem učenika. Naposlijetku, na temelju pregledane literature navode se ograničenja i nude preporuke za daljnja istraživanja.
Active and Reactive Power loss Minimization Along with Voltage profile Improvement for Distribution Reconfiguration
Authors: Badran Ola , Jallad Jafar
Published: December 2023

Optimal distribution network reconfiguration (DNR), distributed generations location and sizing (DGs-LS), tap changer adjustment (TCA), and capacitors bank location and sizing (CAs-SL) are different methodologies used to reduce loss and enhance the voltage profile of distribution systems. DNR is the process of changing the network topography by changing both sectionalized and tie switch states. The optimal location looks to find the optimal setting of the DG and CA within the distribution network. Optimal size seeks to find the optimal output generation of both DG and CA. The TCA looks to find the optimal position for TC. These methods are challenging optimization problems and resort to meta-heuristic techniques to find a globally optimal solution. This paper presents a new methodology with which to simultaneously solve the problem of DNR, DGs-LS, TCA, and CAs-SL in distribution networks. This work aims to minimize active and reactive power losses, including voltage profile improvement using a multi-objective decision approach. The firefly algorithm (FA) and analytic hierarchy process (AHP) are used to optimize the fitness function and determine the function weight factors through the use of MATLAB software. Several scenarios were considered on the IEEE 69-bus network. In terms of active power and reactive losses, reductions in the test system of 96.16% and 92.7%, respectively, were achieved, evidencing the positive impact of the proposed methodology on distribution networks.
A APLICAÇÃO DO MÉTODO 300 NO ENSINO DA MATEMÁTICA NAS TURMAS DE 1º ANO DA ESCOLA DE EDUCAÇÃO PROFISSIONAL JOSÉ VIDAL ALVES
Authors: Oliveira Antoniel Lima de , Silva Francisco de Assis Bento da , Paixão Jonas Agustinho , Sousa Luiz Ricardo Marcolino de
Published: December 2023

É notório as dificuldades de aprendizagem em matemática dos alunos das turmas de 1º ano do Ensino Médio, uma vez que a grande maioria termina o ensino fundamental com uma enorme defasagem dos conteúdos básicos. E essa dificuldade tende a se agravar ainda mais em virtude dos quase dois anos de ensino remoto praticado em função da pandemia. E não bastasse isso, as escolas estão vivenciando um quadro alarmante de alunos com sintomas de depressão e ansiedade ocasionados pelo isolamento e que tem afetado de forma negativa os resultados nas avaliações. Tal situação necessita de que novas estratégias de ensino sejam aplicadas de maneira a amenizar o déficit de aprendizagem em matemática. Diante disso tudo, a presente pesquisa buscou investigar o impacto na aprendizagem da matemática de uma metodologia de estudo cooperativo denominado Método 300 em turmas de 1º ano da Escola José Vidal Alves. O uso do método teve início no começo do 2º período do ano letivo de 2022 e os resultados de rendimento do 2º e 3º período, bem como os dados coletados a partir dos questionários aplicados aos alunos envolvidos na ação, demonstraram resultados satisfatórios no que tange o impacto do método à aprendizagem da matemática.
Effect of Agar Weight Loss with Passive Continuous Air Monitoring According GMP Annex 1 2023
Authors: Ligugnana Roberto
Published: December 2023

The GMP Annex 1 2023 requests that microbial environmental monitoring by active and passive microbial air samplers is actuated by continuous air monitoring. A prolonged sampling produces a loss of moisture in the agar of the Petri dish and therefore it is necessary that during the “continuous time” the dryness of the nutrient media is under control to guarantee a regular growing of the cfu. The purpose of this paper is to evaluate if the agar of settle plate (which volume was reduced with a treatment under sterile laminar flow before aspiration) has still the correct nutrient characteristics during the incubation. The results of the study are summarised in Table 1 and 2. The average loss of humidity after 4 hours in the first part of test under laminar flow was 14,7%. In the second part of test, the Petri dishes aspirated the air in a normal open environment and the average growth after incubation (indicated in cfu/ plate), in comparation with control plates with the original volume of agar, was 87%. The acceptance criteria using the US Pharmacopeia Validation Recommendation for microbiological examination (chapter ) is that the test plates had to recover < 70% of the challenge.
Evaluation of the Therapeutic Efficacy of Functional Devices of Planas: Longitudinal Study of a Population of Young Children Aged 7 to 9 Years, Presenting Incisor Crowding Associated with Skeletal Class I or Class II
Authors: BELKHIRI Amel , Ahmed Fatma Si
Published: December 2023

Objects: Evaluate at the beginning of mixed dentition, the effect of planas plates tracks on disharmony between tooth and jaw size and transverse dimensions of maxillae, on mandibular retrognathia and mandibular growth direction, and on masticatory function. Material and Methods: The study was carried out on a population of 82 school children, aged 7 to 9 years, from the city of Blida, presenting incisor crowding on a skeletal class I or class II. They were divided, by drawing lots, into two comparable groups: a control group and a group having received treatment with track plates associated with selective grinding. Measurements on mouldings, on photos and on face and profile teleradiographies, were performed on each patient before and after one year of follow-up. Results: A significant difference was noted between the two groups concerning the dento-alveolar and masticatory parameters. For the skeletal parameters, the difference is not statistically significant between the two samples. Conclusion: The results confirm the effectiveness of the Planas appliance in the treatment of dento-maxillary disharmony, by expansion and plead in favor of an early treatment, in mixed dentition of this malocclusion. They also show the restoration of chewing function. With regard to the shift of the skeletal bases, if the clinical observations showed its reduction, the measurements did not demonstrate it, due to an excessively small sample size.
Management of Edentulous Patients with Maxillary Substance Loss: A Case Report
Authors: B Bouanane , S Rimaoui , R Zeroual , S Bellemkhannate
Published: December 2023

Depending on the location and extent of the loss of substance following maxillary resection surgery, all functions of the masticatory apparatus may be adversely affected. Eating and communication are impaired, which has a negative impact on the patient's psychological state [1]. When reconstructive maxillofacial surgery is not possible, rehabilitation with a maxillofacial prosthesis is essential. It must restore functions (phonation, eating, breathing, etc.) and reintegrate the patient into his psychosocial environment by masking his disability [2]. To achieve these objectives, this prosthesis, like a conventional removable prosthesis, must meet the Housset triad (support - retention - stabilisation), but also the objective of tightness. We therefore speak of a "prosthetic tetrad in PMF" (Housset's triad completed by the objective of tightness) [3]. In the case of a completely edentulous arch with substance loss, the treatment becomes more complex due to the reduced support surface. The maxillofacial prosthodontist must therefore be extremely vigilant to ensure the success of this appliance. A wise choice of technique and impression material, as well as respect for the occlusal parameters (occlusal plane, vertical dimension, centric relation, etc.) will ensure prosthetic stability and integration [4]. In this article, we will focus on the peculiarities of the management and the different stages in the fabrication of a maxillofacial prosthesis for a patient with total edentulism and loss of maxillary substance.
Systemic Lupus Erythematosus & Stem Cell Therapy
Authors: Albano Samantha , Gallicchio Vincent S
Published: December 2023

Systemic lupus erythematosus is an autoimmune disease characterized by a diverse range of clinical presentation and severe complications involving multiple organ systems. The global prevalence of this disorder ranges from 13 to 7713.5 per 100 000 individuals, with non-Caucasian women at the highest risk of developing the disease. SLE is a social as well as public health problem as this condition ranks among one of the top twenty leading causes of death in females from the age of five to sixty-four years of age and current treatments using multidisciplinary approaches can only work to control symptoms and further progression of disease while no true cure exists. Recent studies involving stem cell therapy in other autoimmune disorders with similar pathogenesis to systemic lupus erythematosus have encouraged clinic trials focused on investigating whether stem cells may be effective in treating this autoimmune disease. Mesenchymal stem cells are multipotent and capable of differentiating into many different cell types and are therefore seen as a promising strategy to treat even severe cases of systemic lupus erythematosus and lupus nephritis. These stem cells have a immunomodulatory effect and are known to affect the proliferative activity of immune cells such as T lymphocytes, B lymphocytes, natural killer cells and macrophages, which are all involved in the pathogenesis of SLE. Clinical trials in progress have indicated promise regarding stem cell therapy as a safe and tolerable treatment, however, further trials must be conducted in order to assess the efficacy of stem cell therapy in the long-term amelioration of disease.
Stem Cells and Lithium with Regards to Alzheimer’s Therapy
Authors: Stephenson Audrey G , Gallicchio Vincent S
Published: December 2023

Alzheimer’s Disease is a condition caused by neural plaques and tangles that affects the lives of millions of people worldwide. The average life expectancy after the initial dementia diagnosis in the United States of America is about 3-4 years. Currently, there is no complete cure for the disorder. However, recent research has been investigating the therapeutic effects of both stem cells and lithium. Stem cells are cells that have the capability to differentiate into other cells when necessary to assist in damage repair. As neurons die off in Alzheimer’s patients, certain types of stem cells have been shown by several studies to be effective in increasing the proliferation of neurons, astrocytes, and oligodendrocytes. Furthermore, stem cell proliferation associated with their transplantation into the brains of rodent models has been studied, and the results demonstrated that rodents had an increased level of cognitive and motor functioning. Lithium has been more recently studied in combination with MSC transplantation therapy and provided promising results, in that it was able to increase neuronal proliferation and differentiation. Alone, lithium is the most potent inhibitor of the GSK-3β pathway that, when hyperactive, leads to the development of Alzheimer’s Disease. This finding has given way to studies that have been able to show that lithium can decrease the plaques and tangles, stemming from Tau hyperphosphorylation, that characterize AD.
A novel nonlinear vibration feature-based approach for evaluating bolt-loosening faults in aerospace structures
Authors: Li Quankun , Jing Xingjian
Published: December 2023

Aerospace structures such as aircraft and satellites are frequently subjected to bolt-loosening faults in service, which will seriously affect structural integrity, reliability and safety. In this paper, the development of a novel approach based on nonlinear vibration features is presented to evaluate potential bolt-loosening faults in these structures. Firstly, the complex aerospace structure is decomposed into some simple T-type substructures based on structural configurations and features. Then, a general T-type multi-degree-of-freedom (MDOF) model simulating bolt-loosening faults and nonlinear boundaries as nonlinear damper-spring components is built for nonlinear vibration analysis. After that, two novel fault features, which are functions of structural properties, nonlinear output spectra and bolt-loosening fault-induced forces, are defined to form a novel bolt-loosening fault indicator. Finally, a novel approach with detailed operational procedures is proposed, and its effectiveness and superiority are verified through experimental studies on a simple lab structure with bolt-loosening faults and nonlinear boundaries.
Published Papers Volume 30 - Issue 4 (Award Issue) Awarded Paper Use of insulation resistance imbalance degree for the condition assessment of power distribution cables
Authors: Zhu Ke
Published: December 2023

Medium-voltage (MV) underground power distribution cables are critical assets of The Hong Kong Electric Co., Ltd. (HK Electric) for ensuring reliable customer power delivery. The inspection and condition assessment of these power distribution cables are conducted regularly to determine their health. During diagnostic tests, all MV cables have to pass a threshold of insulation resistance (IR) before they can be energised. Low IR readings may indicate a deterioration in insulation related to a high leakage current. However, defining a threshold value to assess the intrinsic condition of the power distribution cables for every test is challenging. This is because the reference value is determined by several factors such as cable length, the composition of the cable circuit, e.g., cable type, number and types of cable joints, service years and surface leakage from cable splices and terminations. In order to tackle this problem, a concept of imbalance degree in IR testing is developed to supplement the existing tests on dielectric losses for the purpose of enhancing the condition assessment of three-phase power MV distribution cables when performing IR measurement. The effectiveness of this method has been validated with historical testing records of 11kV distribution power cables at HK Electric. Based on our experience and study results, this improved method could further enhance the diagnosis and maintenance efficacy of HK Electric’s power distribution cables.
STRATEGI PROMOSI DIGITAL MARKETING WISATA RAFTING GUNA MENINGKATKAN POTENSI DESA WISATA
Authors: Fakhriyyah Dewi Diah , Munawaroh Daimatul , Utami Diah , Putri Dita , Nisa' Fadhila Khoirun , Khaliza Fadhila Nur , Ahmad Fandi , Farradina Farradina , Ferlika Ferlika , Jaffan Jacky , Maimun Muhammad , Mudzakir Muhammad
Published: December 2023

Banyu Rancang Rafting Tour which is located in Torongrejo Village, Batu City is experiencing problems in promoting tourism. This is the background for conducting socialization activities and marketing practices both through print and digital marketing media. Activities are carried out using socialization, training and mentoring methods. The socialization material is about digital marketing which is currently a trend to expand market potential. Then the training is carried out by practicing making banner designs and tourism promotion brochures which can later be printed and can also be uploaded on social media. Next is to create a Tiktok social media account and create video content to be uploaded on Tiktok social media accounts, as well as Facebook and Instagram that have been previously owned. The result of this activity is the addition of social media accounts from Banyu Rancang Rafting, namely Tiktok accounts, tourism promotional content videos, brochures both printed and online, as well as banners installed in various strategic places.
A 3D-Printed Forearm Trainer for the Practice of Ultrasound-Guided Arterial and Venous Line Placement
Authors: Chambers Mary E. , Schartung David F. , Resuehr David
Published: December 2023

As sonography (US) continues to become a mainstay in medicine, both as a screening device and as a procedural tool, the use of task-based sonographic trainers (i.e., phantoms) in medical training has become increasingly necessary. This is especially true for what has been termed ‘the global use of US’, or the use of US as an imperative tool during structural planning and placement of peripheral and central lines within patients in emergency and hospital settings. However, despite the frequency and technicality of US-guided procedures involving arterial and venous line placement, the benefit of such hands-on US simulation training for employees and professional students alike is often outweighed by cost. The current market for US trainers displaying human forearm anatomy and branching vessels comes at a high price tag of over 2,000 USD per model. The authors’ experiment utilises 3D printing techniques and biodegradable ballistics gel to create a cost-effective, versatile, and yet realistic peripheral line simulator in order to cultivate real-time learning of arterial/venous arm anatomy, while providing mechanical practice for needle driving and US technique, all at a fraction of the commercial price.
Automated Fiber Placement Laminate Level Optimization for Mitigation of Through Thickness Defect Stacking
Authors: Swingle Noah , Brasington Alex , Halbritter Joshua , Harik Ramy
Published: December 2023

Manufacturing composite structures with Automated Fiber Placement (AFP) requires detailed process planning that is rigorous and time consuming. To facilitate, accelerate and perpetuate process planning knowledge, the Computer Aided Process Planning (CAPP) tool was developed. CAPP assists process planners in identifying optimal layup strategies for each ply of a laminate. This paper expands the established framework for analyzing defect stack-up through thickness of a laminate. Four different combinatorial optimization algorithms are implemented and evaluated: genetic algorithm, differential evolution, particle swarm, and greedy search. The algorithms identify optimal combinations of ply-level layup strategies by analyzing defect stacking using two objective functions. These approaches are evaluated through a digital case study performed on a complex tool surface. The result is a streamlined methodology for comparing different laminate-level manufacturing strategies and minimizing the through thickness defect stack-up.
Volleyball Players Pre-Competitive Anxiety: Sex-Based Differences and Relationship with Sport Characteristics
Authors: Šadrincevaitė Sintija , Griciūtė Aušra
Published: December 2023

Background. The issue of pre-competition anxiety is multidimensional and there is still a lack of complex studies in multiple sports as well as in volleyball analysing the relationships of pre-competitive anxiety with multiple correlates.
Methods. The research participants were male and female volleyball players from fore Lithuanian teams. The questionnaires were completed by 37 athletes (51.4% females) aged between 20 and 41 years (median age 23.0 years). Questions about Competitive State Anxiety (CSAI-2), socio-demographic and sport characteristics were answered 40 minutes before the pre-competition warm-up.
Results. The level of female and male pre-competition anxiety components was similar (p > 0.05). Direct associations were found between cognitive and somatic anxiety in both sex groups (p < 0.001). In the female group, cognitive anxiety was higher compared to somatic anxiety (p < 0.05). In the male subgroup cognitive anxiety was directly associated with age (p < 0.05). Relationships with sport characteristics (N=37): the level of cognitive anxiety was directly related to the number of years of playing volleyball (p < 0.05); volleyball players who reported having sufficient knowledge to manage competitive anxiety had lower levels of cognitive anxiety (p < 0.05), and lower self-confidence (p < 0.05).
Conclusions. The research data may help to better understand the manifestation of volleyball players’ pre-competitive anxiety in sex groups and the relationship with sport characteristics. On the basis of this data, specialists will be able to formulate and test hypotheses of further research as well as select areas of preventive and educational work.
Keywords: volleyball, cognitive and somatic anxiety, self-confidence, gender groups, sport characteristics.
ADBİLİM VE KÜLTÜRDİLBİLİM BAĞLAMINDA LAKAPLAR ÜZERİNE BİR ARAŞTIRMA: TOKAT-NEBİKÖY ÖRNEĞİ
Authors: YAMAN Hanife
Published: December 2023

Adbilimin (onomastik) inceleme alanlarından biri olan kişi adbilimi (antroponimi) dil, insan, toplum ve kültür ilişkisinin çözümlenmesinde etkili rol oynar. Kişi adları dil, toplum, insan ve kültür arasındaki etkileşime dayalı olduğu için bu etkileşimi inceleyen kültürdilbilimin de çalışma alanına girmektedir. Kişi adbiliminin inceleme konularından olan lakaplar dilbilim, folklor ve kültür tarihi araştırmaları açısından da önem taşımaktadır. Lakaplar, toplumun kültüre ait unsurlar aracılığıyla dünyayı algılama ve sınıflandırmasından hareketle kavramları dile nasıl aktardıkları hususunda yol gösterici olmaktadır. Bu çalışmada incelenen lakaplar, Tokat’ın Nebiköy adlı yerleşim biriminden görüşme yöntemiyle derlenmiştir. Lakapların adbilim ve kültürdilbilimsel açıdan tasnifinde Ahmet Keskin’in çalışmasından (2020) yararlanılmıştır. Elde edilen verilerin adbilimsel tasnifinde lakapların veriliş nedenlerine; kültürdilbilim açısından tasnifinde ise sosyo-kültürel özelliklerine dikkat edilmiştir. Elde edilen veriler, adbilim açısından on bir başlık altında tasnif edilerek incelenmiştir. Kültürdilbilim bağlamında yapılan tasnife göre lakaplar, “bireysel ve millî kimliğin dışa vurumu olarak lakaplar”, “kişiler, olaylar ve anlatılar aracılığıyla kolektif ya da bireysel hafızanın anıştırılması bağlamında lakaplar”, “dünya görüşünün yansıması olarak lakaplar” olarak üç temel başlıkta ele alınmıştır. Adbilim ve kültürdilbilim bağlamında yapılan bu çalışmayla, disiplinler arası bir bakışla incelenen lakapların farklı yönleri açığa çıkarılmaya çalışılmıştır. Verilerden hareketle kültürel yorumlamalar yapılmış, yöre insanının dünya görüşü, mizah anlayışı ve düşünüş biçimlerinin dile nasıl yansıdığı ortaya konulmuştur. Nebiköy’de genç nüfusun büyük şehre göç etmesi sebebiyle geleneksel kültüre ait ögelerin yavaş yavaş yok olduğu gözlemlenmiştir. Yöredeki lakaplar üzerine yapılan ve bir envanter niteliği taşıyan bu çalışma geleneksel kültürün korunması hususunda da katkı sağlamaktadır.
ARAPÇA İLE TÜRKÇENİN YABANCI DİL OLARAK ÖĞRETİMİNİN KÜLTÜR AKTARIMI AÇISINDAN KARŞILAŞTIRILMASI (C1 ÖRNEĞİ)
Authors: AL-SHARABI Tawfik Abdo Taher , YEŞİL Yılmaz
Published: December 2023

Türkçe ile Arapçanın yabancı dil olarak öğretiminde hedef yalnızca dil kurallarının, dil sisteminin öğretilmesi değildir. Aynı zamanda kültürel ögelerin aktarımı yapılarak Türk ve Arap kültürlerin tanıtılması da amaçlanmaktadır. Kültürel ögelerin aktarımı Arapça ile Türkçenin yabancı dil olarak öğretiminde temele alınması gereken en önemli ilke niteliğindedir. Aynı zamanda kültür aktarımında bir dengenin olması gerektiği de söylenmelidir. Bu dengenin oluşabilmesi, dilin öğretileceği hedef kitlenin kültürünün de tanınması hatta öğretilen dilin kültürüne de yer verilmesi anlamına gelmektedir.

Bu çalışmada, Arapçanın yabancı dil olarak öğretiminde kullanılan ders kitabı (El-Arabiyye Beyne Yedeyk) ve Türkçe (İstanbul Yabancılar İçin Türkçe Ders Kitabı) öğretim ders kitapları C1 seviyesinin kültür aktarımı bağlamında karşılaştırılması amaçlanmaktadır. Yani Türkçe bilmeyen öğrenciler için ve Arapça bilmeyen öğrenciler için hazırlanan öğretim ders kitapların C1 (İleri düzey) Özerklik seviyesi ile sınırlıdır. Ayrıca kitaplar kişiler arası ilişkiler doğrultusunda belirlenen ögelere (Günlük yaşam, kişiler arası ilişkiler, değerler, inançlar ve davranışlar, toplumsal gelenekler ve gelenekselleşmiş davranışlar) göre incelenmektedir.

Arapça ve Türkçe öğretimi C1 seviyesi incelenip değerlendirilirken materyal olarak “İstanbul Yabancılar İçin Türkçe ders kitabı C1” ve “El-Arabiyyetü Beyne Yedeyk” Arapça ders kitapları kullanılmaktadır. Yabancı dil öğretim ders kitapları hazırlanırken, dilin oluştuğu kültürün unsurlarına da yer vermek gerekmektedir. Baktığımızda yabancı dil öğretiminde en önemli basamaklardan biri öğrenilen dilin kültürünü de öğrenmektir. Çalışmada, belirlenen kitapları C1 seviyesi hem Türkçe hem de Arapça öğretim ders kitabında kişiler arası ilişkilerin alt ögelerini oluşturan günlük yaşam, kişiler arası ilişkiler, değerler ve davranışlar, toplumsal gelenekler ve gelenekselleşmiş davranışlar bakımından incelemesi yapılmaktadır. Bunun için yabancılara dil öğretimi amacıyla yazılmış kitapların o dile ait kültür unsurlarının tanıtıldığı metinlerle donatılması kültürün aktarıcısı olan dilin daha iyi öğretilmesi ve anlaşılmasını sağlayacaktır.
İKLİM DEĞİŞİKLİĞİNİN ÇALIŞMA HAYATINA ETKİLERİYLE MÜCADELE: ADİL BİR GEÇİŞ İÇİN TOPLU İŞ HUKUKU DÜZENLEMELERİNDEN YARARLANILMASI
Authors: Yardımcıoğlu Didem
Published: December 2023

Sanayileşme, orman alanlarının azalması, kentleşme ve fosil yakıt kullanımı gibi çeşitli etkenler sonucu meydana gelen iklim değişikliğinin olumsuz etkileri, günümüzde özellikle de aşırı hava olayları şeklinde kendini göstermeye başlamıştır. İklim değişikliğinin çalışma hayatını ve istihdamı da ciddi şekilde etkilemesi beklenmektedir. Özellikle enerji, su, tarım, balıkçılık, ormancılık, turizm, ulaşım, inşaat ve madencilik gibi doğal kaynaklara ve iklime daha çok bağımlı olan sektörlerin, iklim değişikliğinin olumsuz etkilerine de en çok maruz kalacağı öngörülmektedir. Sera gazı emisyonlarının düşürülmesi, uluslararası anlaşmalar doğrultusunda küresel sıcaklık artışının 2℃’nin altında tutulması için karbon yoğun işlerden yeşil işlere geçiş yapılması ve bu geçişin adil olması gerekmektedir. Bu doğrultuda biz de çalışmamızda konu hakkındaki ulusal ve uluslararası düzenlemeleri ortaya koyarak, adil geçiş kavramını olumlu adil geçiş örneklerini de belirtmek suretiyle açıklayarak, Türkiye’de toplu iş hukuku düzenlemelerinden faydalanılarak adil geçişi sağlamaya yönelik atılabilecek adımları inceleyeceğiz.
Human vs Environment
Authors: Björk Hampus , Mellberg Ebba , Wessbo Simon
Published: December 2023

ABSTRACT
Exploring the hepatoprotective effects of silymarin in experimentally induced- diclofenac sodium toxicity in rabbits
Authors: Haq Shahbaz Ul , Khalid Adeel , Meghwar Khush Hal , Khan Arsalan , Siddiqui Shahrood Ahmed , Ullah Rafiq , Sadeeq Muhammad , Usmani Muhammad Wasim , Ashfaq Khurram
Published: December 2023

The study was aimed to investigate the hepatoprotective effects of varying doses of silymarin against liver damage caused by diclofenac sodium in rabbits. Silymarin, extracted from the Silybum marianum plant, is known for its antioxidant properties and is used to treat liver diseases. The rabbits (n=40) were divided into 4 groups. Group A served as the control (with vehicle solution), group B, as toxin control with diclofenac sodium (50mg/kg intra-peritoneally), group C received both diclofenac sodium and protective dose of silymarin (50mg/kg orally), while group D was administered diclofenac sodium along with higher dose of silymarin (100mg/kg orally). At the study's conclusion, rabbits were humanely euthanized and blood samples were collected for analysis. Enzymes such as Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), direct bilirubin, serum urea, and total bilirubin were measured. The study revealed that higher dose of silymarin (100mg/kg) was more effective in reducing serum enzyme levels compared to lower dose, indicating stronger hepatoprotective effect. This suggests silymarin's potential as the therapeutic agent against liver damage and toxicity induced by substances like diclofenac sodium
Strategies to improve the therapeutic efficacy of mesenchymal stem cell‐derived extracellular vesicle (MSC-EV): a promising cell-free therapy for liver disease
Authors: Zheng Lijuan , Gong Hui , Zhang Jing , Guo Linna , Zhai Zhuofan , Xia Shuang , Hu Zhiyu , Chang Jing , Jiang Yizhu , Huang Xinran , Ge Jingyi , Zhang Bikui , Yan Miao
Published: December 2023

Liver disease has emerged as a significant worldwide health challenge due to its diverse causative factors and therapeutic complexities. The majority of liver diseases ultimately progress to end-stage liver disease and liver transplantation remains the only effective therapy with the limitations of donor organ shortage, lifelong immunosuppressants and expensive treatment costs. Numerous pre-clinical studies have revealed that extracellular vesicles released by mesenchymal stem cells (MSC-EV) exhibited considerable potential in treating liver diseases. Although natural MSC-EV has many potential advantages, some characteristics of MSC-EV, such as heterogeneity, uneven therapeutic effect, and rapid clearance in vivo constrain its clinical translation. In recent years, researchers have explored plenty of ways to improve the therapeutic efficacy and rotation rate of MSC-EV in the treatment of liver disease. In this review, we summarized current strategies to enhance the therapeutic potency of MSC-EV, mainly including optimization culture conditions in MSC or modifications of MSC-EV, aiming to facilitate the development and clinical application of MSC-EV in treating liver disease.
Potential role of N6-methyladenosine modification in the development of Parkinson’s disease
Authors: Zhou Jiale , Han Yang , Hou Ruizhe
Published: December 2023

N6-methyladenosine (m6A) represents the most abundant modification of messenger RNA (mRNA) and is regulated by methyltransferases (writers), demethylases (erasers), and m6A-binding proteins (readers). A dynamic modification process is implicated in nearly every critical stage of RNA metabolism, including mRNA stability, transcription, translation, splicing, nuclear export, and decay. Notably, m6A methylation is significantly enriched in the brain and has recently been shown to be associated with neurodevelopmental disorders and the development of Parkinson’s disease (PD). In this review, we summarize the proteins involved in the process of m6A modification and elucidate the emerging role of m6A modification in PD, which could illuminate alternative strategies for the prevention and treatment of PD.
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells
Authors: Trionfetti Flavia , Alonzi Tonino , Bontempi Giulio , Terri Michela , Battistelli Cecilia , Montaldo Claudia , Repele Federica , Rotili Dante , Valente Sergio , Zwergel Clemens , Matusali Giulia , Maggi Fabrizio , Goletti Delia , Tripodi Marco , Mai Antonello , Strippoli Raffaele
Published: December 2023

Background

Despite the significant progress achieved in understanding the pathology and clinical management of SARS-CoV-2 infection, still pathogenic and clinical issues need to be clarified. Treatment with modulators of epigenetic targets, i.e., epidrugs, is a current therapeutic option in several cancers and could represent an approach in the therapy of viral diseases.

Results

Aim of this study was the analysis of the role of histone deacetylase (HDAC) inhibition in the modulation of SARS-CoV-2 infection of mesothelial cells (MCs).

MeT5A cells, a pleura MC line, were pre-treated with different specific class I and IIb HDAC inhibitors. Unexpectedly, treatment with HDAC1-3 inhibitors significantly increased ACE2/TMPRSS2 expression, suggesting a role in favoring SARS-CoV-2 infection. We focused our analysis on the most potent ACE2/TMPRSS2 inducer among the inhibitors analysed, MS-275, a HDAC1-3 inhibitor. ACE2/TMPRSS2 expression was validated by Western Blot (WB) and immunofluorescence. The involvement of HDAC inhibition in receptor induction was confirmed by HDAC1/HDAC2 silencing. In accordance to the ACE2/TMPRSS2 expression data, MS-275 increased SARS-CoV-2 replication and virus propagation in Vero E6 cells.

Notably, MS-275 was able to increase ACE2/TMPRSS2 expression and SARS-CoV-2 production, although to a lesser extent, also in the lung adenocarcinoma cell line Calu-3 cells.

Mechanistically, treatment with MS-275 increased H3 and H4 histone acetylation at ACE2/TMPRSS2 promoters, increasing their transcription.

Conclusion

This study highlights a previously unrecognized effect of HDAC1-3 inhibition in increasing SARS-CoV-2 cell entry, replication and productive infection correlating with increased expression of ACE2 and TMPRSS2. These data, while adding basic insight into COVID-19 pathogenesis, warn for the use of HDAC inhibitors in SARS-CoV-2 patients.
Impact of CRAMP-34 on Pseudomonas aeruginosa biofilms and extracellular metabolites
Authors: Wang Shiyuan , Ma Chengjun , Long Jinying , Cheng Peng , Zhang Yang , Peng Lianci , Fu Lizhi , Yu Yuandi , Xu Dengfeng , Zhang Suhui , Qiu Jinjie , He Yuzhang , Yang Hongzao , Chen Hongwei
Published: December 2023

Biofilm is a structured community of bacteria encased within a self-produced extracellular matrix. When bacteria form biofilms, they undergo a phenotypic shift that enhances their resistance to antimicrobial agents. Consequently, inducing the transition of biofilm bacteria to the planktonic state may offer a viable approach for addressing infections associated with biofilms. Our previous study has shown that the mouse antimicrobial peptide CRAMP-34 can disperse Pseudomonas aeruginosa (P. aeruginosa) biofilm, and the potential mechanism of CRAMP-34 eradicate P. aeruginosa biofilms was also investigated by combined omics. However, changes in bacterial extracellular metabolism have not been identified. To further explore the mechanism by which CRAMP-34 disperses biofilm, this study analyzed its effects on the extracellular metabolites of biofilm cells via metabolomics. The results demonstrated that a total of 258 significantly different metabolites were detected in the untargeted metabolomics, of which 73 were downregulated and 185 were upregulated. Pathway enrichment analysis of differential metabolites revealed that metabolic pathways are mainly related to the biosynthesis and metabolism of amino acids, and it also suggested that CRAMP-34 may alter the sensitivity of biofilm bacteria to antibiotics. Subsequently, it was confirmed that the combination of CRAMP-34 with vancomycin and colistin had a synergistic effect on dispersed cells. These results, along with our previous findings, suggest that CRAMP-34 may promote the transition of PAO1 bacteria from the biofilm state to the planktonic state by upregulating the extracellular glutamate and succinate metabolism and eventually leading to the dispersal of biofilm. In addition, increased extracellular metabolites of myoinositol, palmitic acid and oleic acid may enhance the susceptibility of the dispersed bacteria to the antibiotics colistin and vancomycin. CRAMP-34 also delayed the development of bacterial resistance to colistin and ciprofloxacin. These results suggest the promising development of CRAMP-34 in combination with antibiotics as a potential candidate to provide a novel therapeutic approach for the prevention and treatment of biofilm-associated infections.