bluuebunny/crossref_metadata_2025 huggingface dataset:
Bicuculline administration into ventromedial hypothalamus: effects on fear and regional brain monoamines and GABA concentrations in rats
Authors: Zagrodzka Jolanta , Romaniuk Andrzej , Wieczorek Marek , Boguszewski Paweł
Published: December 2023

The effects of bicuculline methiodide administration into ventromedial hypothalamus (15 ng per site, bilaterally) on fear behavior and monoamines (NA, DA, 5-HT) and GABA in structures of the brain defensive system (hypothalamus, midbrain gray matter, amygdala, hippocampus and frontal cortex) were studied. Fear behavior was examined in the modified version of light-dark transition test. The time out from the illuminated compartment of chamber, the time spent there and number of returns to the illuminated compartment was measured. Additionally motor activity, i.e., number of crossings and rearings in dark as well as in the illuminated part of compartment, was registered. Blockade of GABAA receptors in the ventromedial hypothalamus resulted in increased fear behavior, i.e. decrease of time out from illuminated compartment and decrease of the time spent there. Motor behavior remained unchanged. HPLC analysis showed reduction of GABA concentration in all investigated brain structures. An increase of NA concentration in all examined structures with exception of the hypothalamus without effect on MHPG/NA was observed as well. Dopamine level remained unchanged, but DOP AC/DA ratio increased in all structures, except frontal cortex. Also HV AIDA ratio increased in the hypothalamus and midbrain. 5-HT concentration increased only in midbrain, 5-HIAA increased in midbrain and in frontal cortex, and 5-HIAA/5-HT ratio increased only in frontal cortex. These results indicate that GABA-ergic and monoaminergic systems remain in functional interactions and that these interactions may play an important role in the neurochemical regulation of fear behavior. The possible mechanism of GABA - monoaminergic interactions is discussed.
MAPK regulation of gene expression in the central nervous system
Authors: Adams J. , Roberson Erik , English Joey , Selcher Joel , Sweatt J.
Published: December 2023

Long-term potentiation (LTP), a cellular model for long-term memory, is generally acknowledged to consist of both a short-term phase that is characterized by a dependence on autonomous protein kinase activity, and a long-term phase that is characterized by a dependence on changes in gene expression and new protein synthesis. Similarly, long-term memory exhibits a dependence on gene expression and altered protein synthesis. Recent evidence indicates that the mitogen-activated protein kinase (MAPK) cascade plays a role in both LTP and long-term memory. The MAPK cascade has heretofore largely been studied in the context of cell division and proliferation and as such, mechanisms for the regulation of gene expression by the MAPK cascade have received considerable attention. Given the possible role of altered gene expression in the late phase of L TP and in long -term memory, we evaluated the capacity of the MAPK ERK (extracellular signal-regulated kinase) to regulate phosphorylation of the transcription factor cAMP response element binding protein (CREB) in hippocampal area CA1. Our studies indicate a critical role for the MAPK cascade in the regulation of CREB phosphorylation in the hippocampus.
NMDA receptors and nitric oxide regulate prostaglandin D2 synthesis in the rabbit hippocampus in vivo
Authors: Łazarewicz Jerzy , Salińska Elżbieta , Stafiej Aleksandra , Ziembowicz Apolonia , Ziemińska Elżbieta
Published: December 2023

The aim of this in vivo micro dialysis study was to characterise the regulation of prostaglandin D2 (PgD2) synthesis by NMDA receptors in the rabbit hippocampus in relation to changes in extracellular Ca2+ concentration (Ca2+e) and nitric oxide (NO) levels. Samples of dialysate were analysed for changes in PgD2 concentration, in Ca2+e and in the level of NO. The results demonstrated that a 20-min pulse application of 0.1-2.5 mM NMDA via a micro dialysis probe induced a prolonged stimulation of PgD2 release that was sensitive to competitive NMDA receptor antagonists. An inhibitor of voltage-sensitive N/ channels, tetrodotoxin, did not influence this effect but significantly suppressed basal PgD2 production, whereas a NOS inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), prevented NMDA-evoked NO release and inhibited NMDA-induced PgD2 release in an L-arginine-sensitive manner. NO donors, S-nitroso-N-acetylpenicillamine and sodium nitroprusside, stimulated PgD2 release. NMDA-evoked decrease in Ca2+e was insensitive to TTX and L-NAME. These results demonstrate an in vivo NMDA receptor-mediated modulation of PgD2 synthesis in the brain, in which NO participates.
Prescrição racional de antibióticos após exodontia
Authors: Pereira Cláudio Maranhão , Barbosa Milka Barreto Amado , Jacobina Rayara Richelle Silvestre
Published: December 2023

Introdução: O surgimento dos antibióticos foi um avanço no tratamento de doenças infecciosas, reduzindo a morbidade e mortalidade associadas às infecções bacterianas. No entanto, o uso indiscriminado desses medicamentos desencadeou resistência bacteriana, um problema que pode afetar negativamente a saúde pública mundial. Na prática clínica, o cirurgião-dentista utiliza antibióticos para tratar ou prevenir infecções. Nas exodontias são usados como medida profilática para evitar infecções como a endocardite bacteriana e disseminação local ou sistêmica da infecção. Nesse contexto, é necessário e fundamental que estudos sobre esta temática sejam desenvolvidos e aplicados na rotina clínica de cirurgiões dentistas, a fim de garantir que esses profissionais exerçam um uso criterioso e indispensável de antibióticos. É de suma importância que os cirurgiões-dentistas estejam adequadamente habilitados para prescrever esses agentes de forma apropriada, abstendo-se assim de recomendá-los indiscriminadamente. Objetivo: Revisar a literatura especializada sobre o uso de antibióticos para exodontia visando destacar indicações, contraindicações, dosagens, vantagens e desvantagens desta prática. Materiais e Métodos: Realizou-se uma revisão de literatura descritiva utilizando como base de dados PubMed, Google Acadêmico e BVS, utilizando combinações entre os descritores: “Antibiotics”; “Antimicrobial Resistance”; “Antibiotic Therapy In Tooth Extractions”. Foram considerados artigos predominantemente dos últimos dez anos, sendo estes revisões de literatura, relato de caso, revisões sistemáticas e meta-análises. A pesquisa foi feita com 40 artigos, sendo 29 selecionados. Conclusão: A remoção de fontes de infecção na cavidade oral e a manutenção da saúde periodontal, aliadas a técnica cirúrgica delicada, são elementos chaves para extrações dentárias sem complicações. Vale reforçar que extração de dente de forma habitual em pacientes com uma boa saúde sistêmica, não necessita de terapia antibiótica.
Cooperativas de energia no Brasil: um referencial teórico para a transição energética
Authors: Villanueva Bernardo de Almeida , Catapan Anderson , Lousada Sérgio António Neves
Published: December 2023

As cooperativas de energia emergem como elementos-chave na transição energética, permitindo que cidadãos se tornem produtores independentes de energia, promovendo uma matriz descentralizada e sustentável. Este artigo apresenta uma sistematização do conhecimento existente sobre as diversas dimensões do cooperativismo de energia, a fim de oferecer uma compreensão consolidada de sua aplicabilidade e potencial impacto na transição energética no contexto brasileiro.
Legal Study on Fulfilling the Rights of Women Prisoners in Correctional Institutions
Authors: Fathonah Rini , Rosidah Nikmah , Maroni  , Anwar Mashuril , Pratama Andre Arya
Published: December 2023

Objective: Female prisoners are prisoners who must be given special protection, especially in fulfilling their rights, because they have different natures from men. With such a nature, it becomes the main basis for the need for legal protection for women. However, in essence, these regulations still generally regulate the rights of prisoners, as we know that women will experience conditions that men do not experience, such as menstruation, pregnancy, childbirth, and breastfeeding. So this becomes further research to analyze the fulfillment of the rights of female prisoners in correctional institutions. This research aims to analyze the implementation of fulfilling the rights of female prisoners based on Law Number 22 of 2022 concerning Corrections.
 
Method: This research is a type of normative juridical and sociological juridical research, with the approaches used, namely the statutory approach, case approach, conceptual approach, and comparative approach. By qualitative research methods, in this research, the data analysis used is qualitative research method analysis models.
 
Result: The rights of convicts must be given due attention in prisons, especially female convicts. Remember that there are many things that women experience that men do not experience, such as menstruation, pregnancy, childbirth, and breastfeeding. However, there is still a lack of facilities such as a lactation room for breastfeeding for prisoners who are pregnant, and/or if the child is having a tantrum, this room can be used so as not to disturb the activities of other prisoners.
 
Conclusion: Fulfilling the rights of prisoners is an important aspect of efforts to create better human resources after training in correctional institutions. The rights of convicts must be given due attention in prisons, especially female convicts. However, there is still a lack of facilities such as a lactation room for breastfeeding for prisoners who are pregnant, and/or if the child is having a tantrum, this room can be used so as not to disturb the activities of other prisoners. Apart from that, there are no regulations that specifically regulate the rights of female prisoners who are pregnant, breastfeeding, and with children.
Proyecto Enlazando Lazos: Estrategias para el Fomento de Habilidades Sociales y de Integración en la Comunidad Educativa
Authors: Choez-Aguilar Johana del Rocío
Published: December 2023

Tanto la familia como la escuela cumplen roles diferentes, se debe tener en cuenta que ambos son parte fundamental para el desarrollo de cada uno de los niños, niñas y adolescentes, por lo que el trabajo que realizan debe ser en conjunto para fortalecer y mejorar lazos. Este proyecto tiene como objetivo general diseñar estrategias para mejorar la convivencia entre docentes y familia en una institución educativa de carácter formal en Ecuador, además de revisar referentes teóricos sobre los temas de la convivencia, conflictos, normativas educativas en Ecuador, diversidad; reflexionar sobre temas como la convivencia y diversidad en el ámbito educativo y la importancia de coexistir en una cultura de paz y aplicar lo aprendido durante el proceso de aprendizaje como estrategias y metodologías educativas en el proyecto. Es importante conocer que para la implementación de este proyecto se utilizarán la metodología activa a través de actividades con fines informativos y participativos que ayudarán al desarrollo de habilidades sociales de toda la comunidad con el fin de una debida integración como lo indica su título “Enlazando lazos”
INSTAGRAM’DA MARKA SAVUNUCULUĞU: MARKA HAYRAN HESAPLARINA YÖNELİK BİR ARAŞTIRMA
Authors: ŞENDOĞAN Fatma , ÖKSÜZ Burcu
Published: December 2023

Bu çalışmada Instagram üzerinde yer alan marka hayran hesaplarının marka savunucusu olarak markaya yönelik içerik üretme ve paylaşım yapma motivasyonlarını ortaya çıkarmak amaç olarak belirlenmiştir. Araştırma kapsamında verilere ulaşabilmek adına yarı yapılandırılmış görüşme tekniğinden yararlanılmıştır. Çalışma grubuna Instagram üzerinden bir marka ya da ürüne yönelik paylaşımlarda bulunan motorlu taşıtlar üzerine 11 marka hayran hesap sahibi dahil edilmiştir. Bu hesaplar içerik analiziyle incelenmiş ve marka hayran hesabı kimliklerinin araştırma konusuyla uyumluluğu saptanmıştır. Çalışma grubunda yer alan bireyler ile gerçekleştirilen 30-45 dakika arasındaki görüşmelerden elde edilen veriler, tema ve kategorilere ayrılmış ve kodlar belirlenmiştir. Araştırma sonuçlarına göre tekrarlı satın alma davranışı sergileyen marka savunucularının bu davranışlarının altında yatan faktörler; marka memnuniyeti, marka güveni, marka bilinirliğine ek olarak ekonomik fayda olarak tespit edilmiştir. Çalışma grubunda yer alan bireylerin savunuculuk faaliyetlerinin altında yatan sebepler ise markanın sosyal algısı ve marka topluluklarına aidiyettir. Instagram üzerinde marka hayran hesabı sahibi olarak marka adına içerik üretme ve paylaşımlarda bulunma motivasyonları çalışma kapsamında elde edilen verilere göre hobi ve kişiselleştirilebilirlik olarak belirlenmiştir. Çalışma grubunda yer alan marka hayranlarının ilgili markalara yönelik sadakat duygusuna sahip olduğu ve marka ile kendisi arasında özdeşleşme olduğu araştırmada elde edilen diğer bir bulgudur.
The pelvis as a focus: Marta Graham, a grammar
Authors: Bragato Marcos , Araújo Douglas , Farias Filho Heronides Fernandes de , Costa Magna da Silva , Chellappa Thiago
Published: December 2023

The American dancer and choreographer Marta Graham (1894 - 1991) inaugurates not only a new way of organizing narrativity and claims in the scene, but how to insert the female body into another kinesthetic and kinetic agenda. With the justification of the need to pay attention to psychological traits, he organizes training with adjustments especially in floor work whose emphasis is on the female pelvis. She herself lends her body to trial and error for what is called the “pelvic truth” house. Today, the vocabulary and syntax of the Graham technique share notoriety, but do not confer its diffusion for requiring unfeasible expenditure in a world “in a hurry”. The technique survives in the midst of the current miscellany of procedures to arrive at the scene.
Exploring women's financial education: A systematic analysis of the literature
Authors: Santos Ticiane Lima dos , Antônio Roberta Veras , Farias Andrezza Carolina Brito , Lima Cássia Regina de , Carvalho Josué de Lima , Martins Luciana Dias Barros , Hummel Sucena Silvia
Published: December 2023

Financial education plays a key role in empowering women in their personal and professional lives. The general objective of this study is to analyze the impact of financial education actions exercised by women in their personal and business lives, through a systematic review of the literature. The methodology adopted in this study consists of a systematic review of the literature, aiming to analyze the financial education actions carried out by women and their impacts on their personal lives and businesses. The results show that the articles converge in a discussion that demonstrates a trend of less access of women to financial education. The studies presented highlight the existence of a gender disparity in access to financial education and highlight the need for additional actions and research in this area. Overcoming this disparity is critical to strengthening women's ability to make informed financial decisions and contribute to their economic independence and future well-being.
Education, literature and humanization: Conversations with Freire and Cândido
Authors: Soares Marta Genú , Oliveira Ivanilde Apoluceno de , Sousa Cleide Santos de
Published: December 2023

The present work results from a bibliographic study, in which it is sought to understand the possibilities of reading the world and human formation, from the literary work and its contribution to liberating education. It is based on Freire's thinking about education from a perspective of problematization, critical formation, humanization and on the ideas of Antônio Candido, for whom the literary work is likely to form and humanize. In this process, we dialogue with the work Acari Zebra, which expresses the life of a rare species native to the Xingu River. Emerique (2018), highlights from this work the living conditions of the species in the waters, which has its natural habitat modified with the implementation of a hydroelectric plant, which also interferes with the way of life of the local population. The work is structured in two topics that are articulated: in the first, the conceptions of Literature, humanization and education are addressed, according to selected authors, then, it is reflected from the mentioned literary work, the link between literature, reality and its social plots. The research highlights the potential of the literary work to think about the complex relationships that human beings establish in society, and with nature in the name of their survival and progress. In view of the above, it can be considered that literature can educate, not according to an official pedagogical ideal, but from the dialogue with the emotions, with the sensitivity of the subjects and stimulating the ability to understand and reflect on reality.
Inspirations from ethnomathematics for the pedagogical practice of teaching geometry
Authors: Pissetti Schayla Letyelle Costa , Soares Eliana Maria do Sacramento
Published: December 2023

We bring some ideas that we obtained when developing doctoral research that is in progress, in which we realized that numerous concepts related to geometry were developed, in an empirical and self-taught way, by subjects who work professionally in different places, even if they do not have formal or formal studies. teachers who instruct them in these activities. To analyze and understand this scenario, we took ethnomathematics, understood as an approach that values the mathematical practices and knowledge of cultures and subjects that use it empirically to deal with their daily lives. We illustrate the report with examples that describe how a subject from the wood industry uses his knowledge about geometric concepts in his professional daily life. We conclude by presenting clues so that mathematics teachers can consider the cultural universe of their students, especially when it comes to ideas related to geometry, to think about their teaching performance, highlighting the importance of mathematics teachers to understand that mathematical reasoning is present. In addition to theoretical formalizations, which can often appear in languages other than those used in formal education.
Comparison of radiation protection effects between epigallocatechin gallate and ascorbic acid
Authors: Nhan Tran Thi , Matuo Youichirou , Izumi Yoshinobu , Abdillah Maradi , Wicaksono Lukas Wisnu , Bac Vuong Thu
Published: December 2023

Ionizing radiation can originate from naturally occurring radiation sources on the earth or it can be from man-made sources. When interacting with cells and living organisms, ionizing radiation produces free radicals, impacting biological molecules such as proteins, lipids, and DNA in the cell nucleus and membrane, leading to cell death or causing cell mutations. Epigallocathecin gallate (EGCG) and ascorbic acid (AA) are well-known natural antioxidants that have been studied and applied as potential radical scavengers. In this study, the radiation protection effects in the presence of EGCG and AA via the scavenging process of free radicals (mainly hydroxyl radicals) were examined. Saccharomyces cerevisiae yeast cells were grown in YDP liquid medium containing yeast extract, peptone, and dextrose/glucose that supplemented with EGCG and AA at different concentrations.  Then, the cell cultures were irradiated with both low (gamma) and high (helium ion beam) linear energy transfer (LET) radiations to evaluate the radiation effect on the survival of the yeast cell.  Both of EGCG and AA play effectively important roles as radiation-protective agent for yeast cells and the effectiveness in radiation protection of EGCG and AA at the same concentration was almost the same between these two additives
Relación entre las habilidades socioemocionales y rendimiento académico en estudiantes de preparatoria
Authors: Góngora Meza Eleana Nínive , De Lille Quintal María José
Published: December 2023

El estudio de las habilidades socioemocionales (HSE) ha experimentado un notable auge en los últimos años conforme los paradigmas de la educación han cambiado; actualmente se tiene una visión más constructivista y humanista de esta, con ello, se ha reconocido la importancia de la educación integral para los estudiantes. La escuela, como uno de los principales entornos de socialización y aprendizaje debe favorecer, no solo el éxito escolar, sino el profesional y personal de los alumnos. Es por ello por lo que, actualmente se insiste en la enseñanza socioemocional como parte del currículo escolar para lograr una educación integral. En función de lo anterior, se diseñó un diagnóstico, para lo cual se creó y aplicó una Escala de Habilidades Socioemocionales a 68 estudiantes, divididos en cinco grupos, de preparatoria y se recolectó el promedio de calificaciones, con el objetivo de determinar si existe relación entre de las habilidades socioemocionales (autoconocimiento, autorregulación y autonomía) y el rendimiento. Los resultados muestran que de manera general existe una relación entre las dos variables, aunque para cada grupo las HSE que se relacionan con el rendimiento académico son diferentes. El diagnóstico determinará una futura intervención que tendrá el objetivo de mejorar las habilidades socioemocionales de autoconocimiento, autorregulación y autonomía para impactar positivamente en el rendimiento académico en los alumnos de primero de preparatoria.
Toxic Cardiomyopathy in a Young Patient Treated for Her2-Positive Early Breast Cancer: Case Report and Literature Review
Authors: Hadžibeganović Amina , Koprić Dijana
Published: December 2023

Objective. We present the case of toxic cardiomyopathy in a healthy thirty-eight-year-old female patient treated for Her2-positive early breast cancer.

Case Report. During the neoadjuvant treatment, the patient received four cycles of AC regimen and four cycles of docetaxel in combination with trastuzumab biosimilar. Two days after she received the ninth dose of trastuzumab biosimilar, she reported feebleness, palpitation, and dyspnoea. A heart ultrasound was performed and was normal without changes in the ejection fraction (EF) compared to previous checks. Three days later she reports worsening of her symptoms that were highly suggestive of heart failure. A cardiologist was consulted who insisted that the patient’s symptoms were the consequence of the disease progression. A CT scan showed signs of heart failure. A heart ultrasound was done and the EF dropped to 30%. Drainage of the right pleural cavity was performed and pharmacotherapy for heart failure was started. The treatment led to clinical improvement, but eighteen months later EF is still not back to normal.

Conclusion. This is a rare case of toxic cardiomyopathy in a young, previously healthy, patient who received anthracyclines followed by trastuzumab biosimilar in combination with taxanes. All the medications this patient received are potentially cardiotoxic. However, the overall presentation is not typical for any of these medications since the patient presented with symptoms and signs of heart failure with significant dilatation of the right atrium, which persists eighteen months after its onset, with only a small increase in the EF. There is also a possibility that the antineoplastic therapy the patient received only facilitated dilatative cardiomyopathy, while the main causative factor was intrinsic or extrinsic.
PROBLEMS MANAGEMENT OF BANKRUPT ASSETS BY THE CURATOR AFTER THE EFFECTIVE EFFECTIVE COURT DECISION
Authors: Pratama Prila Wahyu , Nuranisa Akila
Published: December 2023

The management of bankrupt assets that the court has given authority to the curator and supervisory judge has difficulties and problems such as the difficulty of conducting auctions and selling assets from bankrupt assets and it is also exacerbated by the bankruptcy mafia game in playing with prices during auctions. Using the normative juridical research method, the authors found that problems had indeed occurred and there had been no harmonization of rules and not firm enough rules regarding the independence of curators and also how the management of bankruptcy assets could run more smoothly in order to create justice for the creditors of the debtor.

 
ANALISIS STRATEGI PENGEMBANGAN PRODUK HALAL OLAHAN HASIL LAUT DI KECAMATAN SEPULUH, KABUPATEN BANGKALAN
Authors: Muthafaticha Zahrotul , Putra Trischa Relanda , Prabowo Tripitono Adi
Published: December 2023

Produk halal olahan hasil laut adalah produk yang berasal dari sumber daya laut yang diproses sesuai dengan syariat islam dan memiliki nilai tambah bagi konsumen. Produk ini memiliki potensi yang besar untuk dikembangkan di Kabupaten Bangkalan yang merupakan salah satu daerah penghasil laut di Jawa Timur. Penelitian ini bertujuan untuk menganalisis strategi pengembangan produk halal olahan hasil laut di Kabupaten Bangkalan, dengan studi kasus produk olahan hasil laut di Kecamatan Sepuluh. Metode yang digunakan dalam penelitian ini adalah pendekatan kualitatif deskriptif. Data yang digunakan dalam penelitian ini adalah data primer dan sekunder, lalu untuk teknik pengumpulan data dilakukan dengan cara Survei, Wawancara, Observasi, Studi Dokumentasi dan Fokus Grup Diskusi (FGD). Tahap analisis data dilakukan dengan cara triangulasi. Lokasi penelitian yaitu di Kecamatan Sepuluh Kabupaten Bangkalan. Luaran yang ditargetkan yaitu Publikasi Jurnal Nasional.
Métodos y estrategias de enseñanza orientadas a la innovación pedagógica
Authors: Narváez Vinueza Julio
Published: December 2023

Los métodos y estrategias de enseñanza orientadas a la innovación pedagógica son de gran Importancia para organizar el proceso de la enseñanza aprendizaje, se planifican estrategias para el desarrollo de la transferencia de conocimiento mediante el soporte de materiales curriculares que facilitan la enseñanza, la estrategia didáctica equivale a la actuación secuenciada potencialmente consciente del docente, guiada por uno o más principios de la didáctica. La problemática es la carencia de empleo de métodos y estrategias de enseñanza y de aprendizaje, el cual debe estar actualizado con respecto a los fundamentos teóricos – metodológicos propios de la resolución de problemas y como facilitan su enseñanza. La formulación del problema es: ¿Los métodos y estrategias de enseñanza orientadas a la innovación pedagógica influyen en el proceso de enseñanza – aprendizaje en el aula? El objetivo: indagar los métodos y estrategias de enseñanza orientadas a la innovación pedagógica, a fin de conocer sus características y formas de empleo para mejorar la enseñanza - aprendizaje en la educación. El alcance de la investigación es conocer los métodos y estrategias de enseñanza aprendizaje que se emplean en la educación. La metodología empleada para el desarrollo de esta investigación es documental. Conclusiones: los métodos de enseñanza son técnicas para dirigir el aprendizaje de los estudiantes, mediante el método de casos, método basado en problemas, método de proyectos y las estrategias son organizadores de conocimiento que el docente para promover los aprendizajes significativos.
HEALTH PROMOTING POTENTIALS OF ARMENIAN FUNCTIONAL SOUR MILK “NARINE” AND ITS STARTER LACTOBACILLUS HELVETICUS MDC 9602
Authors: Hovhannisyan H.G.
Published: December 2023

Abstract
This investigation was undertaken for in vitro evaluation of the adaptive and probiotic
properties of Lactobacillus helveticus MDC 9602, the starter of the Armenian functional sour milk “Narine” widely used for curing gastrointestinal disorders and lowering blood pressure. Lactobacillus helveticus species predominantly are used as starters for production of cheeses and fermented sour milk drinks, but a growing body of scientific evidence shows that some strains belonging to this species possesses health benefits. The adaptive properties of MDC 9602, necessary for bacteria viability in the gastrointestinal tract, involve high tolerance to acids, high auto aggregation and hydrophobicity, but low tolerance to bile (0.3%) and NaCl (2%); it does not hydrolyze bile salts, nor utilizes maltose. L. helveticus MDC 9602 produces antimicrobials
sensitive to proteinase K and large amounts of lactic acid, exhibits an antagonistic effect on pathogenic and related bacteria. It is susceptible to many routinely prescribed antibiotics and can considered safe. It is susceptible to many routinely prescribed antibiotics. The beverage “Narine” besides of >1011 CFU/g friendly bacteria, contains a high amount of different proteinases and β-galactosidase, which increases nutritional bioavailability of food. Taking “Narine” prevents gastrointestinal infections, modulates the host’s immune response, improves the composition of the gut microbiota
and lowering high blood pressure. Most of the listed properties of L. helveticus MDC 9602 do not appear in media other than milk. Thus, it was possible to show that the fermented milk product “Narine”, along with live friendly bacteria, also contains a high amount of various hydrolases,lactic acid and bioactive molecules that improve human health and its starter L. helveticus MDC 9602 can be included among the bacterial species commonly considered as probiotics and starter cultures for the production of high quality nutraceuticals.
Impact of Social Capital on Supply Chain Performance: The Role of Information Flow
Authors: Khan Mohsin Taj , Qureshi Imran Munawar , Asghar Muhammad Ali , Hassan Ahmed Faizan , Ashfaq Syed Rizwan
Published: December 2023

The purpose of this paper is to understand how social capital from buyer and suppliers’ perspective effect the performance of the supply chain when information (inflow & outflow) plays a critical role. How social capital enhances the perception of the buyer supplier relationship and their understanding while sharing both ways information inflow & outflow. This change in the perception and how it effects the performance of the supply chain. Also, how social capital plays its role in order to resolve this perceptual difference. With the help of literature review, the buildup of theoretical model and hypothesis was developed. Using the data from 150 respondents collected from many different Pakistani industry manufacturers especially in supply chains and people relate with service industry. For analysis we used structural equation modelling. All of the social capital facets are significant with relation to information inflow, however, with relation to information outflow, structural capital, and performance of the supply chain are not significant. It clearly shows that buyers are more efficient in collection of information, but more reluctant in sharing back (information outflow) with the suppliers. With our results, it shows that buyers should maintain strong social capital and should rely on sharing more information within organization and outside with suppliers, this will enhance, trust, efficacy and will promote performance of the supply chain. Paper develops a framework to test the effect of social capital dimensions on overall supply chain performance where information flow is used as a mechanism facilitating the supply chain performance. This framework has never been tested before. Contribution of the studies and future research has been discussed.
Indicatori cercetare-dezvoltare 2020: Studiu privind asigurarea suportului metodologic pentru monitorizarea indicatorilor Strategiei de Cercetare-Dezvoltare a Republicii Moldova până în anul 2020
Authors: Cojocaru Igor , Cuciureanu Gheorghe , Turcan Nelly , Cujba Rodica , Minciuna Vitalie , Holban Ion , Rosca Alfreda , Grecu Mihai , Cojocaru Irina , Botnaru Viorica , Lemet Elizaveta , Guzun Mihail , Ungureanu Elena , Munteanu Ruslan , Cazacu Elena , Turcan Andrei
Published: December 2023

Scopul principal al prezentului studiu este asigurarea suportului metodologic pentru monitorizarea indicatorilor Strategiei de cercetare-dezvoltare a Republicii Moldova până în 2020, aprobată prin Hotărâre de Guvern (HG) nr. 920 din 07.11. 2014. Cu toate că Strategia în cauză a fost abrogată și că în noile documente de politici acești indicatori lipsesc, studiul în dinamică a indicatorilor de dezvoltare este absolut necesar pentru monitorizarea situaţiei în domeniul
MICRO-SCALE CONTINUOUS CO2 ADSORPTION COLUMN DESIGN WITH ZEOLITE 5A ADSORBENT
Authors: Dahliyanti Ayu , Kartanegara Brian Hardiandra
Published: December 2023

CO2 is the primary greenhouse gas which mainly stems from human activities. Increased CO2 emission in the atmosphere promotes global warming, which adversely affects human health and the environment. Adsorption is proposed as one of the practical and economical methods for CO2 removal. Zeolite 5A is an adsorbent that can be employed in CO2 adsorption due to its high porosity and adsorption capacity. In this study, we investigate the CO2 adsorption behavior by zeolite 5A adsorbent in a continuous, micro-scale fixed-bed column at different bed heights. Gas chromatography was utilized to determine CO2 exit concentrations. The column pressure drop was calculated using Ergun's equation. The obtained data were analyzed in the form of breakthrough curves, then fitted to Thomas and Yoon-Nelson's mathematical model to obtain adsorption rate coefficient in the column. The experimental data of CO2 adsorption by zeolite 5A shows the good correspondence with both Thomas’s and Yoon-Nelson’s mathematical models. At a flow rate of 30 mL/min and bed height variations of 10 and 12 cm, the CO2 adsorption capacities (q0) were 0.0071 and 0.0099 mol/g, respectively. While the Thomas’s adsorption rate coefficient, kTH, for the same conditions were 0.4164 min-1 and 0.4342 min-1.
Peran Otoritas Jasa Keuangan (OJK) dalam Meminimalisir Investasi Bodong yang Dipromosikan Secara Online
Authors: Lubis M. Rizki Darmawan
Published: December 2023

Maraknya investasi yang dipromosikan secara online oleh afiliator menjadikan masyarakat memiliki minat dalam melakukan investasi dan berharap mendapatkan keuntungan. Bermodalkan kepercayaan karena dipasarkan oleh para afiliator yang memiliki follower yang tinggi maka masyarakat tidak memiliki keraguan dalam melakukan investasi. Namun, pada kenyataanya, seiring berjalanya waktu banyak ditemukan investasi bodong yang dipasarkan oleh para afiliator. Oleh sebab itu diperlukan peran Otoritas Jasa Keuangan (OJK) dalam mengatasi permasalahan tersebut. Penelitian ini menerapkan metode penelitian hukum normatif yaitu dengan melakukan studi kepustakaan. Hasil dari penelitian ini menunjukkan bahwa tindakantindakan yang dicanangkan OJK yaitu mengadakan sosialisasi dan penyuluhan kepada masyarakat, memberikan izin pendirian entitas investasi hanya kepada yang memenuhi kriteria, menyediakan layanan pengaduan konsumen, membentuk satgas waspada investasi bodong, mengeluarkan regulasi dan membentuk lembaga perlindungan pasar modal
Analisis Perlindungan Hukum bagi Investor Asing atas Penggunaan Tanah di Ibu Kota Nusantara Berdasarkan Undang-Undang Penanaman Modal dan Peraturan Dasar Pokok Agraria
Authors: Angelica Bernicia
Published: December 2023

Pemindahan Ibu Kota Indonesia merupakan salah satu proyek strategis nasional dalam rangka menciptakan kota berkelanjutan untuk mendatangkan investasi baik dari dalam maupun luar negeri. Beriringan dengan mulainya pembangunan Ibu Kota Nusantara (IKN), pemerintah mengeluarkan kebijakan yaitu Undang-Undang Nomor 3 Tahun 2022 tentang Ibu Kota Nusantara yang kembali diubah pada tahun 2023. Perubahan atas Undang-Undang IKN yang dirasa sangat cepat, dirasa mencerminkan ketidakkonsistenan yang merujuk pada kesimpulan yang mempertanyakan sejauh mana perlindungan hukum bagi investor khususnya investor asing yang akan menanamkan modal di IKN. Mengingat setiap investor pastinya mengharapkan keuntungan semaksimal mungkin atas investasi yang telah ditanamkan di Indonesia. Di sisi lain, beberapa pasal dalam UU IKN menyangkut jangka waktu hak atas tanah yang diatur dalam undang-undang a quo dirasa mendiskriminasi hak-hak masyarakat dan dianggap tidak sesuai dengan peraturan perundang-undangan lainnya, seperti Undang-Undang Nomor 25 Tahun 2007 tentang Penanaman Modal dan dengan Undang-Undang Nomor 5 Tahun 1960 tentang Peraturan Dasar Pokok-Pokok Agraria. Apabila ketentuan tersebut masih dipertanyakan maka akan muncul keraguan bagi investor asing yang ingin menanamkan modal di IKN. Maka dari itu, Penulisan ini bertujuan untuk memahami sejauh mana perlindungan hukum bagi investor asing yang ingin menanamkan modalnya di IKN.
Performance Evaluation of Intel and AMD Memory Hierarchies Using a Simulation-driven Approach With Gem5
Authors: Vieira João Victor Amorim , Souza Matheus Alcântara , Freitas Henrique Cota de
Published: December 2023

Along with the necessity of more computational power, CPUs are evolving quickly. Companies are developing new generations of CPUs every 1–2 years, and many options compete for market share. Hence, researchers and companies must develop a method to compare and select the best processor that fits their needs. This paper presents a simulation-driven alternative for CPU Memory Hierarchy evaluation and comparison. Furthermore, this work compares two rival processors engineered by Intel and AMD. The investigation culminates in the observation that AMD’s processor performs better with fewer cores for several cases, while Intel’s equivalent exhibits enhanced results when all available cores are used.
Case Study on the Use of Winograd-Based Convolution for CNN Inference in FPGA
Authors: Pereira Artur H. C. , Lamar Marcus V.
Published: December 2023

This work explores the implementation of Convolutional Neural Networks (CNNs) on FPGAs. Two circuits are investigated: one based on the spatial 2-D convolution algorithm and another based on the Winograd algorithm for convolution. The Winograd algorithm simplifies the convolution process through linear transformations that reduce the number of multiplications required. However, there is an increase in circuit complexity due to the additional logic to perform the transformations. The two implementations are compared in a case study of a simple architecture to solve the handwritten digits classification problem in the MNIST dataset.
Robotically Assisted Hysterectomy
Authors: Bratila Petre , Manta Anca , Paun Alexandra , Bratila Elvira
Published: December 2023

Starting from the first robotic hysterectomy, currently, this method is widely accepted all over the world as an alternative to open or laparoscopic surgery due to the technical advantages it offers. We are currently using the DaVinci Xi platform, whose components, instruments, and accessories are described. This chapter aims to present all surgical steps of a robotically assisted hysterectomy, starting with patient positioning, uterine manipulator insertion, port insertion, pneumoperitoneum performing, and the operative technique of the total robotic hysterectomy: connective vascular disconnection, colpotomy, uterus retrieval, and colporrhaphy. A special mention belongs to radical robotic hysterectomy with sentinel node detection and pelvic lymphadenectomy. The chapter ends with a brief description of the perioperative complications.
Perspective Chapter: Genomics, Proteomics, and System Biology of Insecticides Resistance in Insects
Authors: Manzoor Malik Rabbiah , Fazal Sahar , Khatoon Narjis , Ishtiaq Muneeba , Batool Saima , Tauqeer Abbas Syed
Published: December 2023

Insecticide resistance is an inherited change in pest population exposure to a specific insecticide or group of insecticides. Overuse, misuse, and high interbreeding rates have led to insecticide resistance. Genomic technologies reveal mechanisms of resistance, including decreased target-site sensitivity and increased detoxification. Genomic projects have cloned and identified targeted genes in Drosophila melanogaster and studied resistance-associated mutations in various pest insects. Advancements in genome sequencing and annotation techniques have explored complex multigene enzyme systems, such as glutathione-S-transferases, esterases, and cytochrome P450, which facilitate insecticide resistance. Identifying specific genes involved in resistance and targeted genes is essential for developing new insecticides and strategies to control pests. Insects with resistance metabolize insecticidal compounds faster due to increased catalytic rate and gene amplification. So, system biology plays a very important role in the insect resistance against insecticides and different chemicals such as DDT and permethrin. From system biology, not only the identification of genes was done, but also the protein-protein interactions were found out, which were responsible in the insect resistance.
FELIKS KONECZNY I JEGO WIZJA CYWILIZACJI EUROPEJSKIEJ (ŁACIŃSKIEJ)
Authors: Sielezin Jan Ryszard
Published: December 2023

The article concerns the vision of European (Latin) civilization by Feliks Koneczny, the outstanding historian of ideas. He created the foundations for apestorier philosophy of history based on the concept of multitude of civilizations. It covers different areas of a human culture and historical activity. Koneczny distinguished seven civilizations in various stages of development, which were a subject of evolution. Culture is one of the foundations of civilization’s development and a part of a bigger entity being one of the fragments of some civilization. The concept of Koneczny brought disputes, which stemmed from a different point of view on the role and meaning of various civilizations and their historical experiences.
Training Of Digital Marketing MSMES In Rejoso Peterongan Jombang Islamic Boarding School Area
Authors: Risnawati Risnawati , Mas’adah Mas’adah , Triono Singgih Cuk , Galahartlambang Yanuangga , Firdawati Yulia
Published: December 2023

The impact of COVID 19 has greatly reduced product marketing for the business world, including MSMEs, especially those still using traditional products. Based on these problems, MSME actors are required to make changes in marketing their products through social media or known as digital marketing. The purpose of this abdimas activity is to provide knowledge and training for MSMEs about digital marketing for marketing by utilizing social media. The method of abdimas activities are lectures, discussions and direct training to MSME actors. The abdimas participants, namely MSME actors in the Pondok Pesantren area, do not yet know the digital marketing system to offer products. The total number of associations is about 125 business actors who follow 25 people. The results from abdimas are that participants get additional knowledge and knowledge about digital marketing starting from the understanding, types, and uses for marketing MSME products and participants can create content and captions to support product picture/photo/video posts on Instagram accounts
Aportaciones a la corología del género Mnium Hedw. (Mniaceae, Musci) en España
Authors: Nieves Marcos Samaniego , Patricia Navarro , Juan Ignacio Cubero , Dinis Manso
Published: December 2023

En este trabajo se incluyen 23 táxones de interés corológico de la familia Mniaceae recolectados en la Península Ibérica. Algunos constituyen novedades provinciales.

In this paper 23 taxa of Mniaceae family with chorological interest are reported from Iberian Peninsula. Several of these taxa are new provincial records.
Cultural Aspects of Technological Grave Visits: A Sociological Assessment
Authors: ÇANKAL Gülsen
Published: December 2023

Abstract

Grave visits have been a deep-rooted religious ritual in many religions and societies throughout history. This ritual is performed with the purpose of visiting the graves of the deceased and is considered an expression of spiritual connection among people. However, with the advancement of technology and the rise of digital communication platforms, this tradition is undergoing a transformation. In today's world, particularly with the increasing popularity of social media platforms, grave visits are taking on a new dimension in the virtual realm. This study aims to examine how the social media profiles of individuals who have passed away, profiles that were used during their lifetime, are visited and interacted with by others after their demise. Furthermore, the research seeks to understand the reasons behind the visibility of the phenomenon of death, which has been pushed into the background in modern societies but is becoming more prominent in what is often termed postmodern societies. This research was conducted using the phenomenological perspective within the framework of qualitative research methods. Within the scope of the study, social media users who visit the social media profiles of deceased individuals on an internet-based social media platform, such as Instagram, and engage in commenting activities were examined. These users offer a significant perspective on how the practice of remembrance and memorialization has become digitalized and evolved. In modern societies, death is often acknowledged as a reality that is either ignored or actively suppressed. However, in postmodern societies, death and memorial rituals are becoming more visible in the digital world. Visiting social media profiles after someone's passing is considered a way to remember them and express a sense of connection. This study contributes to our understanding of how digitalization and technological advancements are impacting societal and cultural practices. It also provides valuable insights into the role of death in postmodern societies. Consequently, it highlights the need for further research into how traditional rituals, like grave visits, have evolved and changed in the digital realm.
Implementasi Simulasi Bencana Oleh Emergensi Respon Tim Di Perusahaan XX Jambi
Authors: Pairi Agus , Ginting Marinawati , Imran Suryadi
Published: December 2023

Rescuing victims due to work accidents is the most important thing for companies to be able to guarantee the safety of their employees, there are several cases that occur related to work accidents such as fires that occur at work locations, moreover these companies have a high risk of these incidents, such as oil and gas companies, to It is necessary to carry out education about work safety through a victim rescue simulation carried out by the company's emergency response team. After receiving the training, there is a need for a simulation of the implementation of disaster victim rescue. After carrying out a simulation by the emergency response team of the oil and gas company, the researcher can conclude that it is necessary to make a routine schedule at a minimum every month to carry out a victim rescue simulation by the emergency response team.