bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of serum progesterone in threatened miscarriage
Authors: Dave Anupama , Patil Ranjana , Bansal Priya , Malhotra Anjali
Published: September 2018

Background: Miscarriage is the inadvertent loss of a pregnancy before the fetus is viable. The World Health Organization defines this un-survivable state as an embryo or fetus weighing 500 grams or less, which typically corresponds to a fetal age (gestational age) of 20 to 22 weeks or less.Methods: The present study was conducted in the Department of Obstetrics and Gynaecology, M. G. M. Medical College and M.Y. Hospital, Indore from October 2013 to October 2014 on 100 patients.Results: The incidence of first trimester threatened miscarriage, in the Gynaec O.P.D. of M.Y. Hospital, Indore, was 8.8%. The most common risk factor was a history of previous miscarriages in 38% of cases while 9% had advanced maternal age and 35% had advanced paternal age. History of preterm labour was positive in 25% cases and that of congenital anomaly in previous pregnancy in 7% cases. UTI and vaginitis were diagnosed in 10% and 11% cases respectively. Systemic illness was in 24% cases while 6% cases had endocrine disorders. On USG missed miscarriage was found in 8% inconclusive ultrasound was found in 34% cases, rest were normal. Of the 38 cases giving history of previous 1, 2, 3 and more than or equal to 4 miscarriages were 22%, 6%, 8% and 2 % respectively. 36% of the patients presented with bleeding per vaginum. only while 30% had bleeding with pain and 33% cases had only pain in abdomen. On USG 58% had normal scans. USG scan was inconclusive in 34% and only 35% continued with viable pregnancy, rest aborted. 7 of the 100 cases had preterm labour and 51 cases continued to term. Rest 42 aborted. H/o contact, travel, trauma, heavy work did not have any statistically proven effect on outcome of pregnancy.Conclusions: Progesterone assays are currently available in most immunoassay platforms and have shown excellent performance in terms of assay sensitivity, specificity, accuracy and precision with rapid turnaround times. Furthermore, the cost per test for progesterone assay is affordable. Several studies have shown that progesterone is the most specific biomarker for distinguishing viable from nonviable pregnancies. The downfall of progesterone as a biomarker is due to the different cut-off values used by researchers. The cut-off values were also determined on different study populations.
Spontaneous pregnancy at term with uterus didelphys: a case report
Authors: Randriamahavonjy Romuald , Ratsiatosika Tanjona A. , Fleurian Sidy , IA Housni , Rakotomboahangy Todisoa M. , Solange Rasoanandrianina B. , Andrianampanalinarivo Hery R.
Published: September 2018

The uterus didelphys results from the absence of fusion of the bilateral mullerian ducts. It is a rare pathology. This malformation concerns 5% of uterine malformations from mullerian ducts and affects one woman in 1,000-30,000. Obstetrical complications of this malformation are numerous. The chance of reaching term for pregnancies with didelphys uterus is reported as 20%–30%. Authors report a case of spontaneous term pregnancy in a 21-year-old primiparous woman with a didelphic uterus. The patient had an unexplained seizure with fetal bradycardia. An emergency cesarean section was performed and allowed the birth of a hypotropic neonate of 2240g and the discovery of didelphic uterus. Pregnancy developed in the left hemi-uterus. Speculum examination at the end of the procedure showed a longitudinal vaginal septum. There was no associated urinary tract and renal malformation. Scheduled cesarean will be performed from her next pregnancy. The uterus didelphys should be diagnosed early. MRI and 3D echography are necessary for diagnosis. Pregnancy is often complicated, and follow-up needs to be planned. Cesarean section is not systematic.
ECMO: a lifesaving modality in ARDS during puerperium
Authors: Juneja Sunil K. , Tandon Pooja , Gupta Vivek , Wander Gurpreet S. , Mahajan Rajesh , Singh Akashdeep , Aggarwal Reetika , Narang Monika , Raina Suhasini
Published: September 2018

Acute respiratory distress syndrome (ARDS) is an uncommon condition encountered in pregnancy. The incidence of ARDS in pregnancy has been reported to be 1 in 6229 deliveries with mortality rates to range from 24% to 39% in pregnant patients. An essential component in management of ARDS involves good communication between the obstetrics team and critical care specialist and a fundamental understanding of mechanical ventilatory support. In critically ill patients where both cardiorespiratory support is required, Extracorporeal Membrane Oxygenation (ECMO) can be used to help maintain the vital functions. ECMO is a temporary cardio respiratory or respiratory support in critically ill patients who are unresponsive to conventional management.  In present case a young female with post-partum ARDS was successfully managed with extra corporeal membrane oxygenation (ECMO).
Universal hearing screening of newborn to detect hearing loss and aid in early intervention: multicentre study
Authors: Yenamandra Kamal K. , Sahu Pankaj K. , Kumar Anil , Rai N. , Thakur Pankaj K.
Published: September 2018

Background: Significant hearing loss is one of the most common major abnormalities present at birth. Screening for hearing loss in new-born is based on two concepts. First, a critical period exists for optimal language skills to develop, and Second, earlier intervention produces better outcomes.Methods: A two-stage screening protocol, in which new-born are screened first with two staged Transient Evoked Oto-acoustic Emissions TEOAE, using handheld TEOAE device, followed by confirmation with Auditory Brainstem Response (ABR). The objective was to study the incidence of hearing impairment in “healthy” and “high risk‟ newborns. A prospective observational study of hearing impairment screening was conducted on 4400 newborns, the study was done as a multi-centre study in 3 different hospitals during January 10 - December 14.Results: 4400 new born, born during the study period were screened, which included 4162(94.7%) healthy neonates and remaining 238(5.3%) high risk neonates. 24 newborn among the cohort of 4400, had hearing impairment confirmed by ABR. The overall incidence of hearing impairment is 5.45/ 1000 screened with 95 % confidence interval between 4.28-11.6. Incidence of hearing impairment in the "no risk‟ group was 2.4/1000 with 95 % confidence interval between 2.01- 4.66. Whereas incidence of 58.8/1000 with 95 % confidence interval is between 1.96-10.32 was seen in "at risk‟ group. Also, this study shows Universal hearing screening of newborns with a two staged screening protocol using TEOAE followed by confirmation with ABR is not only cost effective for detection of hearing loss but also aids in early intervention.Conclusions: The incidence of hearing impairment in our study (5.45 per 1000) is much higher than results shown in previous studies and national average of 4/1000.
Potential therapeutic effects of autologous platelet rich plasma on impaired wound healing: a prospective clinical study
Authors: Upadhyay Sachin , Varma Hashmukh Shantilal , Yadav Sumit
Published: September 2018

Background: The evolving state of technology in field of medicine has led to a plethora of new options in the realm of wound healing. The primary objective of present study was to assess the potential therapeutic effects of autologous platelet rich plasma in the healing of wound.

Methods: A prospective clinical nonrandomized cohort study was performed in 50 patients (40 males, 10 females) with recalcitrant, chronic; non-healing wounds of different etiologies. Age ranged from 25 to 70 years (mean 39.14±13.38). Eligible patients were treated with autologous platelet rich plasma (PRP) at 4-days intervals for a maximum of 14 sessions. Patients were evaluated (reduction in size of the wound (area)) every week and continued until final healing has achieved. The primary outcome was positive response to therapy, defined as complete healing of the wound and absence of any raw area. Significance was set at p<0.05.

Results: The mean time duration to wound healing was 6.33 weeks (S.D±2.16). A statistically significant difference (p<0.05) was observed between the baseline parameters and mean area after PRP injection. After 7 sessions (28 days of therapy) the wounds showed the significant change in wound surface area (p<0.05). None of the patients developed deep or superficial wound infections.

Conclusions: There is considerable improvement in wound characteristics like healthy granulation tissue, healing edge, pain, slough, bleeding on touch and discharge after 7 days of PRP therapy and considerable improvement on follow up.
Pemahaman Hadis Misoginis dalam Kitab Uqudul Lujayn di Pondok Pesantren An-Nur Semarang
Authors: Khozin Akhmad
Published: September 2018

This research is based on the problems in society related to the rights and roles of women who are neglected, because the indications of Hadith misogynically interpreted by classical commentators, on the one hand upholds the dignity of women, but on the other hand castrates women's rights by limiting the women's role in marriage life and closing their steps to contribute in the environment. The purposes of this study are; (1) to know the extent to which the students' understanding of the Hadiths studied in  uqudul lujayn book; (2) to dig into the understanding built in the study of the lqliya texts related to the misogynical Hadith; (3) to imply the understanding to everyday life. The method used in this study is a qualitative method by presenting data through verbal and then changed into description form, not numbers. The results showed that; (1) the santri who studied lqya lujayn book initially did not understand the existence of the misogynous Hadith and only understood the book and the teacher's information, after in-depth study, the students sought to re-understand by combining; (2) in the classical and hermeneutic method of interpretation  can be understood that there is no misogynist Hadith, but Hadits misogynically interpreted; (3) the understanding is implied on the activities of santriwati an-Nur in everyday life.
Acknowledgements
Authors: Bedi Shailoo
Published: September 2018

Acknowledgements 2018
Native versus invasive crab effluent effects on byssal thread production in the mussel, Mytilus trossulus (Gould, 1950)
Authors: Rickaby Rachel , Sinclair Jeanine
Published: September 2018

Mussels have evolved many adaptations to protect themselves, including the production of byssal threads. These are strong, proteinaceous fibres that mussels secrete to adhere themselves to rocks, preventing detachment by waves and predators. These byssal threads may be strengthened if mussels can recognize potential threats, such as native crabs, as their populations have a long history of coevolution. Unfortunately, the introduction of invasive predators poses a challenge for prey, which may not be capable of recognizing them. In this study, byssal thread production in the Pacific blue mussel (Mytilus trossulus ) was observed when exposed to effluent from the native red rock crab (Cancer productus) or the invasive European Green crab (Carcinus maenas). M. trossulus  were placed in closed systems with effluent from either C. productus , C. maenas  or control (no predator), over a 24-hour time period. Final measurements of number, length and diameter of byssal threads were recorded. M. trossulus  exposed to effluent from C. productus produced byssal threads at a statistically significantly faster rate than in the control group over the first 7.5 hours. M. trossulus exposed to effluent from C. maenas  produced byssal threads at a statistically significantly faster rate than both the C. productus and control groups. However, after 24 hours, there was no statistically significant difference between the mean number of byssal threads for any treatment. Additionally, we found no statistically significant difference between the mean diameter of byssal threads produced or length of byssal threads produced for any treatment.
Women in Weed: Gender, Race, and Class in the Cannabis Industry
Authors: Kittel Jacqueline
Published: September 2018

The legitimate cannabis industry is in its developmental stages across North America, leading some to claim that this industry will be a "blue skies market for women" where they will have unfettered opportunities to take on influential and entrepreneurial roles. This discourse, however, ignores the reality that the cannabis industry is just as shaped by gender and intersectional inequalities as other more established industries. Drawing on interviews with five women leaders from various cannabis sectors in Vancouver and Victoria, British Columbia, I explore how gender, racialization, and class operate in this increasingly corporatized sector and how white, heteronormative femininity has been used to normalize cannabis consumption
DISCUSSÕES SOBRE A LITERATURA PARAENSE OU AMAZÔNICA EM PERIÓDICOS BELENENSES OITOCENTISTAS
Authors: Victor Flor da Silva Alan
Published: September 2018

A partir de artigos de teor crítico divulgados na imprensa periódica belenense oitocentista a respeito da literatura produzida por escritores nascidos na Amazônia, objetivamos, com este trabalho, promover uma discussão acerca do que os autores desses artigos pensavam sobre a (in)existência de uma literatura paraense ou amazônica, levando em consideração, sobretudo, uma das proposições de Robert Darnton (2010): a de que os jornais não podem ser considerados como fontes para se descobrir o real, mas sim para saber como os acontecimentos eram interpretados pelas pessoas de uma determinada época.
JORNALISMO E PROJETO DE NAÇÃO NA NARRATIVA FACTUAL MR. SLANG E O BRASIL, DE MONTEIRO LOBATO
Authors: Farias Almeida Simão
Published: September 2018

Monteiro Lobato legitimou debates e questões nacionais em narrativas factuais, associando estilos jornalísticos e literários. Partindo de pressupostos teóricos e históricos de Lennard Davis (1996) acerca de narrativas factuais, Géraldine Muhlmann (2008) sobre jornalismo, polêmica, testemunho e nação, Patricia Waugh (2003) e Linda Hutcheon (1984) em torno da metaficção, demonstraremos como o escritor jornalista representou em Mr. Slang e o Brasil (1927) temas caros ao Brasil na segunda década do século XX: moralidade, burocracia, legalidade, estabilidade política e econômica. Concluíremos que o colóquio-entrevista na narrativa, misto de folhetim e jornalismo interpretativo, aponta impasses, consensos e dissensos nacionais e estrangeiros acerca de fatos comuns à construção da nação. A negociação de projetos de tratado e colóquio entre os personagens corresponde ao arranjo entre projetos político-econômicos distintos e convergentes ao projeto de nação, ordenamento comum à polêmica no jornalismo.
POLÊMICA, PROMOÇÃO E RETROALIMENTAÇÃO: O MANDARIM, DE ARTUR AZEVEDO E MOREIRA SAMPAIO, E SUA REPERCUSSÃO NA IMPRENSA
Authors: Cézar Dias Rodrigo
Published: September 2018

A temporada de apresentação da peça O mandarim, de Artur Azevedo e Moreira Sampaio, foi ensejo para diversas manifestações na imprensa fluminense ao longo dos primeiros meses de 1884. Posto isso, o presente trabalho propõe uma análise formal da peça articulada com a leitura de sua repercussão na imprensa, observando as dinâmicas de polêmica, promoção e retroalimentação que podem ser recuperadas a partir da reconstituição do diálogo entre revista de ano e gêneros discursivos veiculados na imprensa, tais como a crônica, a publicação a pedido, o anúncio publicitário dentre outros.
KAKÁ WERÁ JECUPÉ E A TRADUÇÃO DOS CANTOS SAGRADOS MBYÁ GUARANI
Authors: Cunha Ramos Quaresma Carline , Guimarães Guerra Leal Izabela
Published: September 2018

No presente trabalho, focalizamos a tradução dos cantos sagrados Mbyá Guarani realizada por Kaká Werá Jecupé, que possui um valor peculiar advindo do fato de Kaká ser membro da cultura traduzida. Neste sentido, nossos objetivos são: discutir a especificidade da tradução de Kaká Werá Jecupé e traçar eixos comparativos entre a sua tradução e as de Léon Cadogan (1959), Pierrre Clastres (2011), e  Josely Vianna Baptista (2011), refletindo também sobre o ato de tradução como possibilidade de abertura a outras culturas.
TONALIDADES MÚLTIPLAS NA POESIA DE MARIA REZENDE
Authors: Da Silva Douglas Rosa
Published: September 2018

Resenha de: 
REZENDE, Maria. Carne do Umbigo. Rio de Janeiro: Editora Oito e Meio, 2014.
A Case Report of Duodenal Psammomatous Somatostatinoma
Authors: Foad Ayman Fisal Ahmed , Mirghani Hyder Osman
Published: September 2018

Somatostatinoma is a neuroendocrine tumor; its incidence in the duodenum around the ampulla of Vater is rare, and it is often not associated with secretory manifestation. We report a case of a female with an ampullary (Vater) tumor displaying neuroendocrine nuclear features, psammoma bodies, and the positivity for immunohistochemical panel of neuroendocrine tumors. Our patient presented with some features compatible with somatostatin secretion associated syndrome; albeit with normal serum levels of the hormone. Initial attempt of complete resection failed, and the involved margins were revised with a subsequent surgery, and the patient showed an uneventful course on follow-up for 2 years.
Tutors, The Valuable Resource to Enhance Medical Students’ Motivation.
Authors: Elsheikh Mohamed Nasr , Khalil Reem , Diab Alsarah , Abdalnabi Rayyan , Muneer Mohamed , Elhassan Ahmed , Mohammed Fadwa , Mahalah Shimaa , Khairy Amna , Abdalnabi Shahd , Shammet Salma , Ahmed Munier Islam , Abdallah Ragda , Abdelrahim Mohamed , Mohammed Najla Basheer Ahmed , Husain Nazik Elmalaika , Balla Siham Ahmed , Elhadi Magda
Published: September 2018

Background: Students’ academic performance is largely affected by their motivation. Moreover, health professions’ education needs motivated students who are keen to tolerate the burden of clinical work along with the academic excellence to graduate competently. This study assessed the effect of tutors on students’ motivation.
Method: A cross-sectional, institution-based study of the first-year medical students at University of Khartoum, Sudan was conducted. A self-administered questionnaire was used comprising a modified Motivated Strategies for Learning Questionnaire (MSLQ) with students’ evaluation of their tutors after semester one community medicine course. A total of 237 out of 324 students responded. Pearson productmoment correlation coefficient was used to test the relationship between motivation and evaluation. Hierarchical multiple regression model tested the ability of evaluation factors to predict motivation score.
Results: There was a significant association between tutor’s characteristics regarding creativity in conducting the sessions, igniting discussion, and adequacy of knowledge about the course contents and the motivation score (p-value = 0.001). There was a strong, positive correlation between the perceived evaluation score and perceived motivation score (r = 0.505, n = 206, p < 0.0005). After controlling age, gender, paternal educational levels, and scores of Sudanese certificate upon entry, R squared change = 0.28, F change (9.181) = 8.416, p <0.001. In the final model, the content of the course was statistically significant, standardized Beta = 0.285, indicating that content uniquely explains 5.7% of the variance in total perceived motivation score.
Conclusion: The evaluation score explained 28% of the variance in student motivation. Students’ motivation issignificantly associated with tutor’s teaching skills concerning knowledge, creativity, students’ involvement, and attractiveness in conducting the tutorials. Improving course content can enhance students’ motivation toward community medicine.
Modulação Descontínua para Conversor de Capacitor Flutuante com Controle de Tensão dos Capacitores
Authors: Silva Mauricio M. da , Toebe Ademir , Pinheiro Humberto
Published: September 2018

Este artigo apresenta uma estratégia de modulação descontínua baseada em portadoras para um inversor de capacitores flutuantes de três níveis. Esta modulação é capaz de equilibrar as tensões dos capacitores flutuantes por meio de um controlador em malha fechada implementado em tempo discreto. A modulação descontínua produz na saída do inversor, através da modulação por largura de pulsos, tensões de linha com vários níveis de tensão, resultando em uma baixa distorção harmônica e distribuição igualitária das comutações nos interruptores. Uma máquina de estados é utilizada para decodificar as regiões de modulação com o propósito de reduzir-se o número de comutações. Com esta máquina de estados é proposto um controlador de tensão não linear para o capacitor flutuante de cada braço do inversor. A implementação desta estratégia é simples, além de exigir pouco esforço computacional, podendo ser implementada com facilidade em microntroladores e processadores digitais de sinais convencionais. Finalmente, o artigo apresenta diversos resultados obtidos com implementação em emulador de hardware, validando assim o desenvolvimento teórico e prático da estratégia de modulação.
MARcKS and nAP-22 proteins mRnA expression in renal cortex and renal medulla of rats with spontaneous hypertension
Authors: Aldekeeva A. S. , Kraynova Y. S. , Rudenko E. D. , Klyueva N. Z.
Published: September 2018

Objective. To study the changes in mRNA expression level of two main protein kinase C substrates — MARCKS and NAP-22 — in rats with spontaneous hypertension (SHR rats) and in normotensive control rats (WKY rats) in renal cortex, renal medulla and total kidney. We also aimed at the identification of possible interstrain differences between the mRNA expression levels.Design and methods.We assessed the level of MARCKS and NAP-22 mRNA by real-time polymerase chain reaction in male SHR and WKY (as a normotensive control) rats.Results. In SHR rats, MARCKS mRNA expression level in renal cortex was 1,5 times higher than in renal medulla (p = 0,0001) and also higher than in total kidney (p = 0,001), in renal medulla it was lower than in total kidney (p = 0,002). In WKY rats, MARCKS mRNA expression level in renal cortex was higher than in renal medulla (p = 0,0005). There was no differences neither between renal cortex and total kidney (p = 0,011), nor between renal medulla and total kidney (p = 0,716). In SHR rats, NAP-22 mRNA expression level in renal cortex was twofold higher than in renal medulla (p = 0,001), in renal medulla it was lower than in total kidney (p = 0,005), the differences between renal cortex and total kidney were less significant (p = 0,011). In WKY rats, NAP-22 mRNA expression level in renal cortex was 1,5 times higher than in renal medulla (p = 0,001), while in renal medulla it was lower than in total kidney (p = 0,002). There was no significant difference in NAP-22 mRNA expression level between renal medulla and total kidney (p = 0,011). There were no significant interstrain differences in the animal groups either in the levels of MARCKS mRNA expression in renal cortex (p = 0,872), in renal medulla (p = 0,024) or in total kidney (p = 0,520). Neither there were differences in the levels of NAP-22 mRNA expression in cortex (p = 0,028), in medulla (p = 0,028) and in total kidney (p = 0,978).Conclusions. In both SHR and WKY rat strains, the level of MARCKS and NAP-22 mRNA expression in cortical and medullary kidney layers is different, in WKY rats these differences are less pronounced. At the same time, interstrain differences in NAP-22 and MARCKS mRNA expression levels in cortical, medullary layers and in total kidney of SHR and WKY rats were not found.
Morphology of focal adrenal lesions in patients with adrenal hypertension
Authors: Chobitko V. G. , Maksimova O. V. , Orlova M. M. , Frolova A. V. , Napsheva A. M.
Published: September 2018

Objective. To evaluate the morphologу of focal formations of the adrenal glands after adrenalectomy.Design and methods. We analyzed the adrenal glands of 44 patients who underwent the surgery in the Research Institute of Fundamental and Clinical Urinephrology of Saratov in 2004–2016. Renovascular hypertension was the exclusion criterion.Results. The majority of the examined patients (72,7 %) had adrenal hypertension, caused by hormonally active adrenal tumors: pheochromocytoma, corticosteroma and aldosterome. Hormonally inactive tumors were found in 12,5 % patients with adrenal hypertension. Therefore, essential hypertension was diagnosed in these cases. In total 27,3 % patients underwent resection of the incidentalomas, among them 16,7 % were diagnosed as “silent” chromaffin tumors which do not lead to the blood pressure elevation.Conclusions. In the majority of cases (87,5 %), patients who undergo surgery due to adrenal focal formation demonstrate adrenal hypertension related to a hormonally active tumor. Adrenal hypertension is more often diagnosed in middle-aged women, who show higher blood pressure, smaller adrenal glands compared to those who have hormonally inactive adenomas. Based on the morphological study, asymptomatic pheochromocytoma was diagnosed in 16,7 % cases.
Screening blood pressure measurement in the Russian population (the results of the МММ17 activity)
Authors: Rotar O. P. , Tolkunova K. M. , Mevsha O. V. , Nedbaikin A. M. , Kochergina A. M. , Chernova A. A. , Shepel R. N. , Rubanenko O. A. , Posnenkova O. M. , Evsevieva M. E. , Cojocari C. G. , Makeeva E. R. , Tanicheva A. A. , Konradi A. O. , Shlyakhto E. V.
Published: September 2018

Background. The International Society of Hypertension and World Hypertensive League therefore joined forces to organize a concerted global effort by expanding World Hypertension Day to May Measurement Month 2017 (MMM17). The campaign was aimed to improve hypertension awareness and blood pressure control in participants with hypertension. Russian Society of Cardiology supported initiative — blood pressure measurement was performed in 11 Russian cities.Objective. The aim of our study was to estimate Russian population awareness about blood pressure in terms of campaign MMM17.Design and methods. During May 2017 we screened 1532 participants in 11 Russian cities: St Petersburg (119 participants), Moscow (102), Belgorod (28), Bryansk (405), Kemerovo (142), Krasnoyarsk (154), Samara (67), Saratov (59), Stavropol (269), Ulyanovsk (50), Surgut (137). All subjects participated voluntarily. Inclusion criteria was age age older than 18 years old. Blood pressure (BP) was measured three times with automated and manual sphygmomanometers. Questionnaire regarding diabetes mellitus, cardiovascular diseases, smoking and alcohol intake was filled in. Respondents provided information about weight and height.Results. We examined 1532 participants aged 39,3 ± 18,7 years (from 18 to 90 years old), among them 509 (33,2 %) males and 1023 (66,8 %) females. All participants were divided into 3 groups according to the date of the last BP measurement: group 1 — BP has never been checked before (n = 188, 12,3 %), group 2 — less than one year ago (n = 630, 41,1 %), group 3 — more than one year ago (n = 714, 46,6 %).Conclusions. About half of Russian participants checked blood pressure last time more than one year ago. Insufficient awareness, low compliance to antihypertensive medication and poor blood pressure control were found in Russian population independently of gender and age in both primary and secondary prevention.
Dynamics of the sales of fixed-doses antihypertensive combinations in the southern regions of the far Eastern federal district
Authors: Soboleva M. S. , Loskutova E. E.
Published: September 2018

Background. Advantages of the two-component drugs are well-known and described in the professional standards and guidelines. However, in clinical practice their application is often limited, despite the increase in the variants of full-doses combinations.Objective. To analyze the dynamics of sales of the fixed-doses antihypertensive combinations in regions of the Far Eastern federal district.Design and methods. We present the results of the pharmacoepidemiological study of the regional pharmaceutical market of the antihypertensive fixeddoses combinations in Khabarovskii, Primorskii region and the Sakhalin region in 2015–2017.Results. In the studied regions of the Russian Federation, combinations of angiotensin-converting-enzyme inhibitors and diuretics are the most popular. Leading ones appeared to be enalapril + hydrochlorothiazide and perindopril + indapamide. Combinations of angiotensin-converting-enzyme inhibitors with dihydropyridine derivatives calcium channel blockers were acquired seldom. The most popular combinations were perindopril + amlodipine and lizinopril + amlodipine. Among combinations of angiotensin II antagonists with diuretics losartan + hydrochlorothiazide and valsartan + hydrochlorothiazide showed the greatest sales. Combinations including sartan and calcium channel blockers were acquired more seldom, despite the wide range of international non-proprietary variants in drugstores. Atenolol + chlortalidone was in the most popular demand among combinations of β-blockers with diuretics. In 2016 three-component combinations were presented by only four trade names, and their demand is still limited. Nevertheless, a nonsignificant growth of purchases was observed.Conclusions. Our data show low demand of fixed-doses combinations. In regions, as a rule, there is an increase in sales of generic more affordable combinations which proves the significance of both antihypertensive efficiency and the price.
Markers of chronic kidney disease in high-risk hypertensive patients: relationship with abnormal circadian blood pressure profile and intrarenal vascular resistance
Authors: Koshelskaya O. A. , Zhuravleva O. A. , Karpov R. S.
Published: September 2018

Objective. To determine the frequency of markers of chronic kidney disease (CKD) in hypertensive patients, and to assess their relationship with the circadian blood pressure (BP) profile and intrarenal vascular resistance.Design and Methods. We studied 70 patients with medically-controlled hypertension (63,2 ± 8,3 years, m — 48,6 %, office BP was 130,5 ± 13,7 / 78,1 ± 8,5 mm Hg), 40 patients were recruited from the Russian multicentre program CHRONOGRAF. Measurement of the office BP, ambulatory BP monitoring were performed. Glomerular filtration rate (GFR) was calculated using the CKD-EPI formula, and albuminuria (AU) was determined as albumin/creatinine (A/Cr) ratio in the morning portion of urine (n = 40) or 24-hour urinary albumin excretion (UAE) (n = 22). Intrarenal vascular resistance was estimated by renal duplex Doppler ultrasound. The resistive index (RI) levels in the main renal arteries (MRA) and intrarenal arteries (IRA) were calculated.Results. Markers of CKD (GFR < 60 ml/min/1,73 m2and/or A/Cr > 30 mg/g and/or UAE > 30 mg/day) were detected in 31,4 % of patients with well-medically-controlled hypertension: average values of BP-day and BP-night were normal. The frequency of markers of CKD was 44,4 % in patients with BP-night ≥ 120/70 mm Hg (40,9 %) and 28,2 % in patients with BP-night < 120/70 mm Hg (58,1 %). A/Cr ratio was positively associated (Rs = 0,3550, р = 0,0266), GFR was negatively associated (Rs = –0,3795, р = 0,002) with systolic BP-night. RI in the segmental intrarenal arteries correlated with GFR (Rs = –0,4232, p = 0,0005). Renal RI were higher in CKD-patients vs. non-CKD-patients. During the ROC-analysis, the threshold value of RI in segmental IRA 0,725 to the detection of CKD markers (sensitivity of 71,4 %, specificity of 68,9 %, AUC = 0,699) was established. Among the diabetic patients, there were more marked disturbances of renal hemodynamic in the presence of CKD markers: RI in arcuate IRA reached 0,73 (0,68–0,75).Conclusions. The high frequency of markers of CKD (31,4 %) was identified even in patients with well-medically-controlled hypertension, it was associated with systolic BP-night. The negative correlation was found between GFR and RI. Renal hemodynamics was significantly disturbed in the presence of CKD markers, especially in patients with type 2 diabetes mellitus. The cut-off point of RI in segmental IRA indicating the CKD markers is 0,725.
Marketing Gaps and Intersections, Between Education and Social Practice: the “Win-Win-Win Papakonstantinidis Model” and the High-Risk Ethical Priorities (HREP)
Authors: Papakonstantinidis Leonidas A.
Published: September 2018

Given gaps and intersections between education and social practice, this article goes to the next step. Efforts are focused on “what must be done,” what policy must be applied so that gaps and intersections must be eliminated, that means “all about the graduated from any education level could be absorbed by the labor market in a period. Conventional policies have failed, and alternative solutions are promoted by the scientific community among them, some scientists propose quite new forms, as the compassion-social entrepreneur. In this volume-section a quite radical reversal concept is proposed Instead of “good trade practices” in the frame of a high risk hard competitive market’s environment”, the “High Risk Ethical Priorities” is proposed taking into account market trends, and competition. From this point of view, the term “High Risk Ethical Priorities” (HREP) is introduced (for the first time), by this article. Finally, the two criteria, the Chi-square and the NE have been used, for the point of the unique equilibrium (deviation=0) be detected.
Fighting for the Moral Cause? State Motivations for Humanitarian Intervention
Authors: Sublette Alayna , 2016 Class of
Published: September 2018

Why do states conduct humanitarian missions in certain states and not in others? This paper evaluates the motivations of states to intervene in other states under the guise of humanitarianism, with a focus on multilateral military operations. Further, the main factor that this paper addresses is the role that human rights non-governmental organizations (NGOs) play in influencing states to intervene or not intervene, with an emphasis on NGO naming and shaming. By conducting a comparative case study between the civil conflicts in Kosovo and Rwanda, this paper tests the following hypothesis: the more comprehensive an NGO’s naming and shaming campaigns are in a particular state in regard to a humanitarian issue, the more likely an outside state will intervene in that target country. Although Kosovo and Rwanda both had naming and shaming, the difference lies in the amount and substance of the naming and shaming. This paper argues that Kosovo received more naming and shaming at a higher quality, while Rwanda received less naming and shaming at a lower quality. Further, this paper argues that these differences in naming and shaming contributed to the differing outcomes; Kosovo received substantial international attention, while Rwanda did not.
Dance, The Divine, and The Devious Other: Orientalism and the Presentation of Race and Gender in the Work of Ruth St. Denis
Authors: Kee Krista , 2016 Class of
Published: September 2018

Ruth St. Denis is considered to be one of the pioneers of American modern dance. She was a performer and choreographer often mentioned alongside the historical giants of modern dance like Isadora Duncan and St. Denis’s own protégé, Martha Graham. Ruth St. Denis’s Eastern-inspired and ornate dance spectacles earned her significant notoriety and enthralled audiences. St. Denis certainly contributed to the evolution of the American modern dance tradition; however, her success also highlights the presence of Orientalist thought in Western culture. St. Denis focused much of her work on what she referred to as Oriental Dancing. Orientalism refers to the idea that the East is spiritual, sensual, and intriguing. Orientalism overlooks the wide variety of cultures and nations in the Eastern Hemisphere and conveniently names them all as exotic other, thus degrading and oversimplifying them. An analysis of two of St. Denis’s most prominent works, Incense and Radha, reveals how Orientalism insidiously affects the perception of both race and gender in dance spectacle while reinforcing imperialist attitudes of Western superiority.
Hana Jaafari Discusses Her Research in Biophysics
Authors: Jaafari Hana , 2017 Class of
Published: September 2018

Video Segments:

Can you describe your research and findings? 0:04-0:46

What inspired you to do this research? 0:47-1:19

What are y’all hoping to do with this research? 1:20-1:43

Has this inspired you to do more research? 1:44-2:09

Can you break down what you were researching? 2:10-2:31

What was your favorite part? 2:32-2:52

What was the most challenging part? 2:53-3:12

Did you have a strategy for getting over the tough parts? 3:13-3:30

What was the research process like? 3:31-3:44

Was it hard balancing school and research? 3:45-3:56

Did you have creative freedom or was your research more structured? 3:57-4:10

What skills did you gain from this? 4:11-4:31

What are the main things readers should know about your research? 4:32-4:57

What is your advice for students doing research? 4:58-5:31
Cailin O'Mara Reflects on her Study of Parental Communication
Authors: O'Mara Cailin , 2018 Class of
Published: September 2018

Video Segments: 

Can you describe your research? 0:04-0:51

Can you describe the research process? 0:51-1:26

Can you say more about your data? 1:26-1:37

What was the biggest challenge? 1:37-2:20

What inspired your research? 2:20-4:24

Do you have any advice for students? 4:24-5:01
Sarah Westphal Discusses her Research in the Secondary Education Classroom
Authors: Westphal Sarah , 2017 Class of
Published: September 2018

Video Segments: 

Can you describe your research for us? 0:04-1:59

What was the research process like? 1:59-4:54

What was the biggest challenge? 4:54-6:14

What was your favorite part? 6:14-7:23

What do you want readers to know? 7:23-8:46

What’s your advice for student researchers? 8:46-9:45
Meriel LeSueur Reflects on her Honors Colloquium Coursework
Authors: LeSueur Meriel , 2017 Class of
Published: September 2018

Video Segments:

How did you first learn about honors colloquia? 0:04-0:52

What classes have you taken? 0:52-1:13

Do you have a favorite? 1:13-1:54

What have these classes taught you? 1:54-3:05

What is the most challenging part of these classes? 3:05-4:03

What are the benefits of these classes? 4:03-5:05

Advice for those choosing between departmental honors or colloquia? 5:05-5:55

What’s your advice for students going into colloquia? 5:55-6:45
The Syrian Refugee Crisis: Media Coverage and Humanitarian Response
Authors: Ritchie Kelsey , 2017 Class of
Published: September 2018

Since 2011, the conflict in Syria has caused over 13.5 million Syrians to leave their homes, 4.8 million of which are refugees outside of Syria. Over the span of the six-year conflict, media coverage of the crisis has received both praise and harsh criticism. This paper focuses on the question of how media coverage of the crisis affect levels of response. The first part of this study is a content analysis of tweets from four news organizations. The analysis collects data on the number of tweets concerning the refugee crisis, as well as the content of those tweets. Secondly, the study uses an experimental design to test these findings. The researcher partnered with a local refugee organization to make policy recommendations in regards to social media campaigns. These two research designs found that tweets that contained visuals and were more anecdotal resulted in more response. However, the majority of coverage was more focused on numbers and statistics. Therefore, the conclusion and implications of this study found the need for a stronger relationship between news outlets and humanitarian aid organizations to 1) gain access to stories about refugees rather than solely hard news, and 2) to incite more tangible response.
Environmental Health Literacy Promotion Within the TCU Campus Community
Authors: Dohnalek Sophie , 2017 Class of
Published: September 2018

An emerging field, environmental health literacy (EHL) aims to equip the public with information and risk communication tools that are applicable and easily understood. This study aimed to determine whether environmental health (EH) education impacts the likelihood of student, faculty, and staff to reduce or stop the use of products that are known to negatively impact health. To address the need for improved EHL, education sessions to promote EHL took place on an urban private university campus among students, faculty, and staff. Students, faculty, and staff on the TCU campus participated in an EH education session. Pender’s (1982) Health Promotion Model and evidence from the Agency for Toxic Substances and Disease Registry (ATSDR) informed session development.  

Each session consisted of a presentation, hands on demonstration, and group discussion. Participants completed baseline surveys and discussion questions were recorded and transcribed. The investigator used descriptive and content analysis methods to evaluate these data. Twenty-seven participants (17 students, 10 faculty/staff) attended one of five group sessions. Of those, 81.5% reported no prior EH education; however, 77.8% indicated awareness of natural alternatives. An estimated 95% of participants felt the lesson motivated them to make informed choices and educate others. Key barriers to applying EHL in daily life included lack of understanding and education on the topic (37%), cost (33.3%), and brand familiarity (26%). Education sessions promoted EHL among students, faculty, and staff. These sessions have the potential to improve understanding of EH, and the overall health of the community by empowering individuals to make informed choices.
LiNK: The Role Gender Plays in Recess Activity Levels throughout the School Day
Authors: Schwene Diana , 2017 Class of
Published: September 2018

The purpose of this research study was to focus on the physical activity differences during recess of grade one children. This study compared activity levels of grade one males and females during each of four unstructured recess times, scheduled at fifteen minutes each, and determined the activity patterns of children during each of these recess time periods. The results showed no significant differences for either category of data measured. The data categories included total recess step counts by day and total step counts for gender for each recess. The lack of significant difference supports the effectiveness of unstructured play over structured play in the recess setting. Unstructured play is a key aspect of the LiiNK project and the data shows that without balls to enable sporting behaviors and high adult intervention in play, both genders exhibit similar numbers of steps. It will be important to look at the differences between the intervention school results that were found in this study versus the recordings taken in a control school to further explore the impact of the LiiNK project as a whole.
Nostalgia Serves as a Psychological Resource for Mothers of Children with Autism Spectrum Disorder: A Pilot Study
Authors: French Katherine , 2017 Class of
Published: September 2018

The current study examined whether nostalgia, a sentimental longing for the past, serves as a psychological resource for mothers of children with ASD (autism spectrum disorder). Twenty-six mothers of children with ASD were asked to complete measures of well-being during an initial visit. Over eight weeks, mothers were asked to write about their experiences with raising a child with ASD, which were coded for the use of nostalgic language. The results revealed that mothers who reported being lower in positive affect and parental well-being had increased nostalgic narratives over time. There were no significant findings for negative affect and life satisfaction. THis work provides a first step in understanding the relationship between nostalgia and mental health. Specifically, nostalgia may serve as a potential intervention to improve the well-being of parents and children with ASD.
Clinical observation of metastatic thyroid disease in a patient with breast cancer
Authors: Bondarenko E. V. , Gurevich L. E. , Kotova I. V.
Published: September 2018

Metastatic tumors of the thyroid gland (TG) are rare. Usually thyroid gland metastases originate from renal, lung, skin and gastrointestinal cancers. Breast cancer metastases are more rare and in various samples amount to 3 to 34% of all cases of the metastatic thyroid disease. We present a rare case of metastatic carcinomatosis into the thyroid goiter in a 63-year old female patient who has received combination therapy for breast cancer. In 2016, right-sided mastectomy was performed due to the right breast cancer (invasive carcinoma, non-specific type, Grade 2, with skin invasion) with subsequent four chemotherapy courses. A slowly growing nodule in the thyroid gland was first found in 2012; in 2017, fine needle aspiration biopsy was performed, which showed a follicular tumor that resulted in thyroidectomy. At the histological examination, against the background of thyroid goiter, multiple small lesions with advanced nuclear polymorphism were found, with doubtful diagnosis. To clarify the histogenesis of the tumor lesions, immunohistochemical assessment was performed. Its first phase included the markers of primary thyroid tumors (thyroglobulin, TTF-1), and the second one consisted of the breast cancer diagnostic panel (mammoglobin, GATA-3, estrogen and progesterone receptors). The results showed multiple small metastases of the invasive breast carcinoma of non-specific type into the thyroid goiter. Taking into account eventual problems of differential diagnosis and significant morphological polymorphism of thyroid tumors, we recommend extending of the immunohistochemistry panel in this patient category.
A pesquisa e a extensão universitária como impulsoras de um trabalho de preservação patrimonial na cidade de Itapira
Authors: De Oliveira Raíssa Pereira Cintra
Published: September 2018

O tema da preservação patrimonial tem ganhado gradativa importância no país, porém, é visível a dificuldade encontrada pelos agentes públicos em implantar políticas culturais nessa direção. Não diferente é a região em que está inserido o Centro Universitário Adventista de São Paulo (Unasp), campus Engenheiro Coelho (SP), onde ainda existem bens de grande importância artístico-histórico, mas que dependem de iniciativas voltadas para a sua valorização. O presente artigo pretende explanar sobre um projeto iniciado em junho de 2017 que almeja integrar pesquisa e extensão universitária com o intuito de estabelecer uma efetiva política pública na área da preservação patrimonial na cidade de Itapira (SP). A pesquisa foi realizado através de duas frentes de trabalho: o estudo de alguns edifícios, iniciando um inventário das edificações; e ações ligadas à educação patrimonial promovidas em parceria com as Secretarias de Turismo e Cultura, e de Educação, promovendo palestras e oficinas sobre o tema da memória e da preservação patrimonial. Além disso, foi realizada coleta de memórias orais com alguns cidadãos a fim de entender os significados desse espaço estudado no imaginário das diversas gerações com o intuito de promover a sensibilização para o tema e a criação de uma agenda política de ações voltadas para a preservação.