bluuebunny/crossref_metadata_2025 huggingface dataset:
Öğretmen Adaylarının Öğretmen Profesyonelliğine İlişkin Görüşlerinin İncelenmesi
Authors: GÜVEN Sibel , KIRAT Emel
Published: January 2022

Farklı mesleki alanlarda öne çıkan profesyonellik kavramının öğretmen profesyonelliği çerçevesinde değerlendirildiği bu araştırmada öğretmen adaylarının profesyonellik kavramına ilişkin görüşlerinin incelenmesi amaçlanmıştır. Bu doğrultuda profesyonel kişi ve öğretmen özellikleriyle birlikte öğretmenlik sürecine hazırlığı temsil eden lisans eğitimi, profesyonel kişi ve öğretmenlerin sahip olması gereken özellikler öğretmen adaylarının araştırma sürecine katılımıyla değerlendirilmiştir. Nitel yöntemin izlendiği bu araştırma durum çalışması deseninde yürütülmüştür. Bir devlet üniversitesinde Okul Öncesi Öğretmenliği, Türkçe Öğretmenliği ve Fen Bilimleri Öğretmenliği bölümlerinin 3. ve 4. sınıflarında öğrenim görmekte olan toplam 88 öğretmen adayı araştırmanın çalışma grubunu oluşturmaktadır. Elde edilen veriler içerik analizi tekniği ile analiz edilmiş, ana temaları oluşturan yapılar doğrultusunda sonuçlara ulaşılmıştır. Araştırmadan elde edilen sonuçlar öğretmen adaylarının profesyonel öğretmenleri mesleki alanda uzmanlaşan, gelişime ve yeniliğe açık olan, geleceği inşa eden, iş birliği kurabilen kişiler şeklinde değerlendirdiklerini göstermektedir. Bununla birlikte öğretmen profesyonelliği sürecinde uygulama boyutları birçok noktada vurgulanarak bu boyutun eksikliği ve geliştirilmesine yönelik öneriler öne çıkan sonuçlar arasında yer almaktadır.
[RETRACTED] SCAM ALERT! PT Trim Fat Burn Reviews: Real Customer Complaints v1
Authors: not provided pttrimfatburn
Published: January 2022

[RETRACTED]

PT Trim Fat Burn is a weight loss supplement sold exclusively online through PTTrimFatBurn. By taking two capsules of PT Trim Fat Burn daily, you can purportedly use a weight loss shortcut involving purple tea to rapidly lose weight. Does PT Trim Fat Burn really work? or is PT Trim Fat Burn yet another weight loss supplement scam? Keep reading to discover everything you need to know about PT Trim Fat Burn and how much weight you can lose.
[RETRACTED] SCAM ALERT!PT Trim Fat Burn Reviews: 2022 Must Read Before Order v1
Authors: not provided health
Published: January 2022

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>>>VISIT OFFICIAL WEBSITE BUY NOW:[UK,US,AU,CA] <<<<
[RETRACTED] Five Doubts You Should Clarify About MaasaLong Reviews! v1
Authors: Reviews MaasaLong
Published: January 2022

[RETRACTED]

MaasaLong Reviews
[RETRACTED] HempLeafz CBD Gummies Canada & USA Reviews – Do These Gummies Work Or A Scam? v1
Authors: not provided clickhempLeafz
Published: January 2022

[RETRACTED]

https://www.mynewsdesk.com/iexponet/pressreleases/hempleafz-cbd-gummies-reviews-canada-and-usa-ingredients-and-hemp-leafz-cbd-gummies-canada-website-3151581
[RETRACTED] Summary of Nuubu Detox Patch Review 2022 v1
Authors: not provided clickhempLeafz
Published: January 2022

[RETRACTED]

https://www.laweekly.com/nuubu-detox-patches-reviews-uk-canada-usa-updated-price-of-nuubu-foot-patches-scam-website-alert/
[RETRACTED] Must Read! Trim Fat Burn Reviews: Does It Really Works Or Scam? v1
Authors: Lee John
Published: January 2022

[RETRACTED]

PT Trim Fat Burn is a straightforward, efficient, and powerful supplement that delivers weight loss promise in the US,AU,UK and Ireland.
[RETRACTED] PharmaLabs Keto Pills Reviews v1
Authors: not provided pharmaLabsketoeviews
Published: January 2022

[RETRACTED]

PharmaLabs Keto Pills Reviews
New Evidence of the Effect of Literacies in Reducing Disinformation and Fake News
Authors: Ledur José Ricardo , P. dos Santos Renato
Published: January 2022

Context: The production of scientific knowledge is not clearly understood by most individuals. In the information age, society faces challenges generated by discrediting institutions, including science, the proliferation of false news, disinformation and the relativisation of truth. These are significant issues that the school cannot refrain from discussing if it wants to educate for citizenship. Objectives: To investigate how conceptions about science influence and are influenced by fake news conveyed by the media and the contribution of literacy to minimise the effects of misinformation. Design: The methodology used in this research used a mixed-methods approach through content analysis of students’ responses combined with descriptive statistical techniques. Environment and participants: The research was carried out with 32 students, divided into two groups, attending the 9th grade of an elementary public school in Bom Princípio/RS. Data collection and analysis: Two questionnaires were applied: one for the conceptions about science and another to identify fake news. Results: Most students have a limited view of science and find it difficult to identify fake news through verification criteria. A correlation between student perceptions and the identification of false news was observed. Conclusions: Knowledge about science possibly enhances students’ perception of doubtful information. It is crucial to develop mediatic and information literacy skills as they can positively impact the identification of fake news and reduce its shares.
Report on the sessions of the gynecological section of the first Congress of Russian doctors in Moscow from January 3 to January 10, 1891.
Authors: Massen V. N.
Published: January 2022

The gynaecological section started on January 7. The case was opened by the head of the section, Dr. P. I. Dobrynin
Surgical treatment of urinary incontinence of urethral origin in women
Authors: Gimmelfarb G. I.
Published: January 2022

Congenital urinary incontinence in women is observed with various anomalies of the genital apparatus, among which cases of female epispadias are of particular interest due to their extreme rarity.
Twelve gluttonies
Authors: Tyshko I.
Published: January 2022

Pulcheria B., 30 years old, a peasant woman in Dukhovshchinsk district, Smolensk province, was admitted to the hospital on July 12, 1991, complaining of pain in the lower abdomen, sacrum and lower back.
Results of measurements of female pelvic outlet
Authors: Massen V. N.
Published: January 2022

As we said (see page 6). of all narrow cans we measured 178. Their owners belonged to the most diverse places in our fatherland, namely: a native of St. Petersburg province. there were 53 (29.77%), Tverskaya 23 (17.79%), Novgorod 23 (12.92%), Pskov 8 (4.49%), Arkhangelsk and Ryazan 7 each (3.93%) , Smolensk and Yaroslavl 6 (3.37%) and less than 6 from other provinces. There were 8 women of non-Russian origin (or 4.49% of the total), namely: 4 from Finland, 2 from Estonia and one from Warsaw and Plock province. Thus, bearing in mind such an insignificant number of non-Russian taz, we, as we think, can attribute the results of our measurements to the Russian taz without a big error.
OBSTETRIC GYNECOLOGICAL SOCIETY IN ST.-PETERSBURG
Authors: Ott D. O.
Published: January 2022

Attended by: Honorary Member K.F.Slavianskiy, 21 members: Antipov, P.A., Batsevich, Viridarskiy, Grinev, Dimant, Dobrovolskiy, V.N., Dolinskiy, Dranitsyn, Zheltukhin, Zamshin, Kakushkin, Lichkus, Massen, Piotrovich , Rutkovskiy, Rymsha, Salmanov, Serezhnikov, Stelmakhovich, Stravinskiy, Ulrikh and 35 guests.
Graviditas extrauterina tubaria sin .; rupture of the fetal sac; gluttony in extremis; recovery
Authors: Kakushkin N.
Published: January 2022

A month after urgent regular blood (in a 30-year-old patient who gave birth once), severe uterine bleeding and then, after the bleeding stopped, within 4 months, a mucous-bloody fluid was constantly released from the genitals.
Pelvic suppuration. Acute inflammation of the sacroiliac joint
Authors: Kakushkin N.
Published: January 2022

A 25-year-old peasant woman suddenly fell ill with fever, pain in the right sacroiliac joint and the inability to control the right leg.
A case of overgrown genital warts on the genitals of a young girl
Authors: Kakushkin N.
Published: January 2022

A 22-year-old girl who denies sexual intercourse.
Volvulus in postpartum parametritis, celiac disease, recovery
Authors: Kakushkin N.
Published: January 2022

The washerwoman, 31 years old, gave birth 4 times, the last time (correctly) 4 weeks ago. Sick from the third day after childbirth.
On the question of the influence of age and sexuality on the rate of absorption of certain medicinal substances from the stomach in healthy women
Authors: Kakushkin N.
Published: January 2022

Of the 73 women investigated by the author, 49 were taken to determine the effect of age on absorption, 16 - the effect of pregnancy and 8 - the effect of menstruation.
Heart defects and pregnancy
Authors: Kakushkin N.
Published: January 2022

The significance of heart defects for pregnancy is assessed by the authors differently.
To casuistry of foreign bodies in the vagina
Authors: Kakushkin N.
Published: January 2022

We are talking about a homemade ring inserted into the vagina with incomplete prolapse of the uterus by the patient herself and stayed there for more than two months.
Vomiting in pregnant women
Authors: Kakushkin N.
Published: January 2022

For one thousand hospitalized pregnant women, the author observed indomitable vomiting once, while among the smaller number of pregnant women from private practice (more secure class) this disease was encountered by the author three times.
Is strychnine contraindicated to pregnant women?
Authors: Ginzburg M.
Published: January 2022

Dr. Barker does not report his observations on strychnine.
A Socio.hu Társadalomtudományi Szemle folyóirat pozíciójának feltérképezése a hazai társadalomtudományi folyóiratok kontextusában : Egy „pilot” vizsgálat tanulságai
Authors: Soós Sándor
Published: January 2022

A nemzetközi kutatásértékelésben hosszú évtizedek alatt uralkodóvá vált trend, a biblio-, illetve tudománymetriai teljesítménymérés az akadémiai szféra mellett ma már az összes kapcsolódó szféra, így a tudományos folyóiratkiadás szereplőinek életében is alapvető tényező. A szakfolyóiratok szerepe messze túlnőtt azok eredeti funkcióján: a hagyományosan a tudományos kommunikáció csatornái – illetve a szerkesztőségük – ma már minőségüket, hatásukat, presztízsüket jellemző mérőszámok alapján felállított rangsorpozíciókért versenyeznek a részben rajtuk keresztül értékelt szerzői körük megtartása és bővítése céljából. A bemutatott vizsgálat célja a Socio.hu Társadalomtudományi Szemle mint hazai társadalomtudományi folyóirat szerepének, pozíciójának feltárására ebben a kontextusban. Elsődleges célján, a Socio.hu-ra vonatkozó helyzetjelentésen túl módszertani kísérletként, egyfajta „pilot” tanulmányként is felfogható, amennyiben az úgynevezett „sokdimenziós folyóirat-értékelés” (Haustein 2012) módszertani keretébe illeszkedik, ugyanakkor annak mérőeszközeit a jelen kontextus, vagyis a hazai társadalomtudományi folyóiratok ökoszisztémájának mérhető aspektusaira adaptálja.
Addressing Risks of Lead in Water and Soil
Authors: Filippelli Gabriel , Hicks Ivan , Druschel Gregory , Kelly Jason , Shukle John , Strout Spencer , Nichols Natalie , Stroud Dawson , Ottenweller Megan , Ohrberg Makayla , Longbrake Marisa , Wood Leah , Clark Benjamin , Fryling Kevin
Published: January 2022

One of the most widespread environmental health hazards in the United States remains exposure to the harmful neurotoxin lead. So much lead remains in the urban environment that it is not unusual to find neighborhoods where more than 10% of children exhibit harmful levels of lead, compared to the national average of about 1%. To overcome this challenge, a partnership between IUPUI researchers and faith organizations in Indianapolis is taking aim at the risk of household lead contamination by providing residents the tools they need to protect against it. The community-driven science aspect of this project is intentional—not only will the individuals who participate benefit directly, but the resulting data will also play a role in keeping communities safer more broadly.
Exploring University-Community Collaborations
Authors: Kryder-Reid Elizabeth , Fillipelli Gabriel , Boyd Phyllis , Brooks Paula , Nadaraj Aghilah , Sangsuwangul Alvin , Humphrey Leah
Published: January 2022

The Riverside neighborhood bears multiple burdens of environmental harm. Running the gamut from groundwater contamination in subsurface waters to lead in soils and dust and paint to particulate matter in the air from highways and industry, these environmental insults harm the physical, mental, and economic well-being of the community. The community has also faced an information gap where data was scarce, hard to locate, and sometimes wrong. Activists have long worked to improve the quality of life in the neighborhood, but faced barriers in the form of policies (e.g. Red Lining, zoning variances, disinvestment in public services such as street lights and sidewalks) and practices (e.g. absentee landlords, illegal dumping). Features such as the Central Canal that were developed into recreational amenities in other parts of the city were minimally maintained or restricted from use by residents. In the face of these challenges, IUPUI faculty, students, and community members have partnered on multiple projects to document the history of environmental harms, assess exposure and risk of residents’ exposomes, and share information in ways that are accessible and relevant for residents. The work supports the agency and activism of the community, particularly as it faces pressures of gentrification and university encroachment with the prospect of 16 Tech project expansion. The work also takes place in the context of contested interests and harmful legacies as representatives of an urban university that displaced longtime residents work to partner ethically and transparently with those same communities. As a result, current faculty-community collaborations operate within a space complicated by the problematic legacy of harm and ongoing structural racism. However well-intentioned, faculty, students and community members have to navigate that history and enduring power dynamics as they design their research, identify relevant questions, and share results in ways that are accessible and meaningful to community members.
Water is Life
Authors: Tanana Heather
Published: January 2022

Water is life. Every household in America needs and is entitled to clean and safe water access. Yet, the magnitude of lack of clean water access in Indian country is significant and startling. Our report uncovers the four main factors that have exacerbated gaps in tribal drinking water access, and in turn hurt public health and economic growth:
More Than Just an Academic Exercise
Authors: Welton Anajale , Cumings Mansfield Katherine
Published: January 2022

Critical policy analysis (CPA) is a means by which to critique policy and promote agency, equity, and justice. However, most CPA scholars examine political discourse from a distance rather than actively participate in political processes. Meanwhile, there's a growing interest in community-engaged research whereby academics partner with community members in their research endeavors. In this article, we consider the value of conjoining the philosophies and processes behind both CPA and community-engaged research to create more powerful and meaningful research endeavors that potentially can lead to political action and policy change. For this article, we present a subset of data from a larger study that asked education policy scholars how critical policy analysis informs their work and what they consider to be key objectives of this approach. We focus on a subsection of participants who demonstrated how and what ways they consider community-engaged scholarship to be an essential component of CPA.
Changes in macular thickness post uncomplicated MSICS & phacoemulsification surgery
Authors: Anand Kartika , Dokania Ashutosh
Published: January 2022

To evaluate changes in macular thickness via-a-vis visual acuity post uncomplicated manual small incision cataract surgery (MSICS) & phacoemulsification surgery

Prospective clinical study on 160 patients of uncomplicated immature senile cataract, aged 40-70yrs, patients were randomised into two groups, MSICS & phacoemulsification, by simple 1:1 randomization, who underwent uncomplicated cataract surgery with posterior chamber intraocular lens (PCIOL). Post-operatively, the patients were evaluated for best corrected visual acuity (BCVA) and changes in macular thickness by optical coherence tomography (OCT) at post-op Day 1, 7, 21, 48, and 12 weeks. Paired t-test was used for comparison across follow up.

: At 12 weeks post-operative, mean logMAR BCVA was 0.01±0.02 for MSICS group and 0±0.02 for Phacoemulsification group. Macular thickness was not statistically significant (p=0.342) between MSICS group (219.19±17.88µm) and Phacoemlusification group (215.61±16.21µm), at the end of 12 weeks post-operative. Clinically significant macular oedema was not diagnosed in any of the patients at the follow-ups.

: Both procedures achieved good post-operative Best Corrected visual acuity without significant differences in BCVA between both the groups at the end of 12 weeks.
Clinical profiles of patients with optic neuritis and papillitis: A prospective study
Authors: Chaurasia I D , Chaurasia Yogita
Published: January 2022

To analyse the demographics and presenting features of patients presenting with optic neuritis and papillitis.

Clinical profiles of 40 patients presenting with optic neuritis and papillitis at a tertiary care center were collected retrospectively and prospectively. Detailed medical and ophthalmic history was taken especially about mode, duration and course of the disease, drug intake, alcoholism, smoking, pregnancy, lactation, convulsions, pyrexia, history suggestive of TB, syphilis, neurological deficit. A comprehensive ophthalmological and neurological evaluation was done for each patient along with radiological work up. Patients were prospectively followed up for an average of three months.

Females in the reproductive age group constituted largest number of the patients (61.8%) in the present series. Maximum patients (70%) were between 20-50 years of age. Vision was found to be affected in all the patients at presentation and most of them presented with vision CF or HM (35.4% and 29.25% respectively) while 4 patients had complete loss of vision. Two third (66.7%) of patients reported eye pain at presentation. Abnormal pupillary reaction was found in most patients with the most common being RAPD on swinging flash light which was seen in 85.4%. Equal percentage (39.5%) of patients presented with Blurred Hyperemic (BH) disc and ophthalmoscopically normal appearing disc. Onset and progression of disease was found to be rapid in most cases ranging from few hours to days. Visual recovery post treatment was found to be good with most eyes achieving vision 6/24 or better.

Optic neuritis has varied clinical presentations. Most of our patients were young to middle aged females. The most common presenting features were decrease in vision ranging from slight to profound, eye pain and abnormal pupillary reaction. Morphological abnormalities in appearance of optic disc were also found in two third of cases.Rapid progression was noted in almost all cases. Most of the cases achieved a good outcome at the end of follow up period.
Profile of ocular injuries amongst various trauma patients presenting to tertiary care centre of Punjab
Authors: Bhatti Anubha , Kakkar Arushi , Singh Shakeen
Published: January 2022

To study the epidemiology and clinical profile of ocular trauma patients presenting to tertiary care centre.

Prospective study. All patients of ocular trauma in OPD/Emergency were assessed for detail between 1/1/17 to 31/6/18 and data on demographic profile was established as per guidelines of Ocular Trauma Society of India. Patients were categorized in different segments and assessed/followed for visual impairment in particular.

A total of 246 cases were examined out of which 87% were males. The most common mode of ocular injury was Road Traffic Accidents. Pediatric eye trauma constituted 16.7% of the total cases. 26.8% cases arrived to our centre between 4-24 hours and 62.6% cases presented after 24 hours. Amongst 131 cases of Road Traffic Accidents, none of them were using protective measures like helmets or goggles. Of these, 17.1% were under the influence of alcohol. 28.5% were involved in medicolegal proceedings. Majority of the cases comprised of monocular trauma (78.1%). Closed globe injuries constituted 88.94% of the total cases of which most cases presented with lid edema and ecchymosis. Chemical injuries were reported in 4.5% cases. 9 patients lost vision completely and 71 cases had vision from light perception to 6/18.

Ocular trauma is one of the common causes of ocular morbidity. It has been seen predominantly in male population. Public needs to be educated about safety measurements and education about prompt need to specialised care to reduce ocular trauma related visual morbidity.
Slit lamp photography for objective assessment of topical eye disorders
Authors: Biradar A B , Das Arun , Adeeb A
Published: January 2022

Evidence based scientific studies has weightage, when they are presented with quantitative data analysis. Documentation and parametric analysis has become an integral part of present day research. Any publications or write-ups without explanation through standard parameters are not appreciated by the research society.

In Ophthalmology assessment of various parameters through photography is a debatable issue. Affordability for higher end diagnostic / OPD instruments may not be feasible for all. In such a scenario, here is an attempt made to standardize the slit lamp photography with a smart phone and its scientific analysis for evaluating clinical conditions like sub-conjunctival hemorrhage, etc.

This technique can become a tool for assessment and response of the therapies as well as an important tool to seek help from higher centers. Various add-on benefits in research, limitation and scope for further evaluation also being discussed.
Visual outcomes and intraoperative complications of small incision cataract surgery performed by junior residents in GMC
Authors: Naik Vishaka , Usgaonkar Ugam P .S
Published: January 2022

To evaluate in intraoperative complications of MSICS performed by Junior Residents and to compare the incidences of major complications in the first six months of training versus last six months of training.

It is a retrospective type of study. From March 2018 to February 2019 a total of 293 manual SICS were conducted by the Junior Residents in Department of Ophthalmology. Each of the patients underwent a detailed ophthalmological examination preoperatively and underwent MSICS under peribulbar anesthesia. Consents for surgeries were obtained from each patient.

Following intraoperative complications were noted: tunnel related complications, capsulorrhexis related complications, Iridodialysis, posterior capsular rent, zonular dialysis, vitreous leak, surgical aphakia, Descemet membrane detachment, placement of ACIOL, Nucleus drop and IOL drop. The patient’s immediate postoperative vision was also noted.

SPSS version 15.0.

Tunnel related complications were found in 13.98% patients either as scleral button holing or premature entry. Posterior capsular rents and bag disinsertion were found in total of 11.94% patients owing to which 3.07% were left aphakic. 63.13% patients had visual acuity better than 6/12 by snellens chart on first postoperative day.

Performance of adequate anterior capsulotomy, minimal handling of the cornea and avoidance of posterior capsular rent are some of the challenges faced by the residents while learning MSICS. Stepwise supervised training can help a resident doctor master these steps while keeping the complications at acceptably low levels.

Stepwise supervised training of residents performing MSICS can minimize complications
Pattern and risk factors of retinopathy of prematurity in tertiary care centre
Authors: Shende Snehal , Gour Richa , Melwani Veena , Singh Priti , Kumar Kavita
Published: January 2022

Retinopathy of prematurity is one of the commonest cause of blindness in sick neonates exposed to excessive oxygen following NICU admissions. The present study was thus conducted to assess the pattern and risk factors associated with incidence of retinopathy of prematurity.

A retrospective record based study was conducted at tertiary care centre between 1st July 2017 to 30thMay 2020 were screened for ROP. Baseline characteristics and risk factors for ROP were assessed. The zone and stage of ROP were categorized as per the International classification of ROP along with iris neovascularisation and plus disease as per the revised international classification of retinopathy of prematurity (ICROP) preplus disease criteria. Data was entered in excel sheet and analysed using SPSS software version 20.

Majority of neonates belonged to gestational age of 28 to 31 weeks (58.8%) and 51.2% neonates had birthweight of 1.5 to 2 kg. Male preponderance was observed with male: female ratio of 1.75:1. Amongst the various risk factors, the occurrence of ROP was highly significantly associated with gestational age and birthweight (p<0.01). Subgroup analysis revealed that aggressive posterior ROP (APROP) contributed significantly to Type I ROP in 11.1% (3) cases. And the observed difference in gestational age and birthweight between APROP and other cases of ROP were statistically highly significant (p<0.01).

Early and timely screening of ROP for all high risk neonates especially low birth weight and neonates with small gestational age should be mandatory as these are the most significant risk factors associated with ROP in present study.
Effect of heparin sodium on postoperative inflammation after adult cataract surgery
Authors: Ganekal Sunil , Dorairaj Syril , Ganekal Varun
Published: January 2022

To evaluate the effect of use of ringer lactate solution supplemented with heparin sodium in patients undergoing cataract surgery.

In a prospective, double-blind, interventional study, 200 patients were included and were randomized to undergo cataract surgery using ringer lactate solution with or without 10 IU/ml heparin. All patients underwent phacoemulsification with hydrophobic acrylic foldable intraocular lens (IOL) implantation. The severity of anterior chamber inflammation and amount of pigment deposition of IOL was assessed by slit lamp biomicroscopy on day 1, 7, 28 and after 8 weeks postoperatively.

Mean age in treatment and control group was 63.0± 11.5 years and 65.1±12.7 years respectively. A significant reduction in the severity of inflammatory cellular activity (p=0.001), flare (p=0.001) and pigment deposition on IOL (p=0.001) was noted on day 1 in the heparin treated group compared to the control group. However, no significant difference was observed in the amount of inflammatory activity as well as IOL pigment deposition beyond 1 week postoperatively. The inflammatory activity resolved almost completely in both the groups by the end of 8 weeks postoperatively.

: Our study showed the beneficial effect of addition of heparin to irrigating solution during cataract surgery. Heparin treated eyes demonstrated a reduction in the early postoperative inflammation and IOL pigment deposition. The anti-inflammatory effect was observed in the early postoperative period.
Field changes on automated Humphrey’s field analyzer in tuberculosis following ethambutol therapy
Authors: Shrivastava Poorva , Morskole Sheetal , Shrivastava Lalit
Published: January 2022

This study was conducted to evaluate the visual field changes in tubercular patients on anti-tubercular therapy and to assess the reversibility of these changes after the discontinuation therapy.

This study was conducted as a prospective analytical study at tertiary care centres in Bhopal and Jabalpur on all newly detected tuberculosis patients. Ocular history, relevant history was recorded and detailed ocular examination was done at the time of presentation, before initiating ATT. All the patients were followed up periodically till the cessation of treatment and three months thereafter.

A total of 40 cases of newly diagnosed tuberculosis were registered with mean age of 38.4±13.99 years. We documented significant deterioration in visual acuity after 3 months of initiation of therapy. Once the ATT was stopped, the improvement in visual acuity was statistically significant 3 months after the cessation of ATT as compared to visual acuity 3 months after initiation of ATT (p<0.05). But residual visual impairment even after stoppage of ATT was observed. Color vison and visual field defects were observed in higher proportions of eyes following initiation of ethambutol which improved significantly after 3 months of cessation of ATT (p<0.05).

Ethambutol, even in recommended dose according to DOTS, has been associated with ocular toxicity which manifests in the form of painless progressive loss of vision, color vision defects and visual field defects. Though these changes are usually reversible, few patients have irreversible damage. Thus, patients receiving ethambutol must be explained regarding these effects and followed up periodically.
Clinical profile of anterior uveitis in tertiary health centre of central India
Authors: Upadhyay Varun , Lakhtakia Sujata , Sastya Baldev , Tiwari Anamika
Published: January 2022

To study the clinical profile of anterior uveitis in patients attending the Ophthalmology department of tertiary health centre of central India

A cross-sectional, observational study was done in the department of Ophthalmology of tertiary health centre from January 2017 to July 2019. A total of 199 cases of anterior uveitis were studied to assess their clinical presentation and etiology. After thorough history taking, demographic data and clinical pattern were documented. Comprehensive ophthalmic evaluation, necessary laboratory investigations and radiological imaging were performed to establish the etiology.

The maximum number (n=79; 39.7%) of patients were in the age group of 21-40 years and the mean age of the study subjects was 36.9+21.8 years. The male to female ratio was 1:1.42 (117 females, 82 males). Uniocular disease was found in 91.95% cases and majority (n=175; 87.93%) of the patients had acute presentation with 95.47% cases having non granulomatous uveitis. A specific diagnosis could not be made in 62.8% cases. Trauma (21.7%) was the most common cause in patients with a specific diagnosis. Persistent posterior synechiae was the most frequently seen complication (21.08%) although majority of the patients (66.8%) did not reveal any major complications.

Patients with anterior uveitis most commonly had acute presentation. The disease was rarely bilateral and was mostly non-granulomatous in presentation. It was mostly idiopathic and among the known etiological factors, trauma was the most common cause.
Traditional eye medicine associated keratitis- Current trends and practices
Authors: Preethi B  , Babu G Suresh , Mittal Preeti , Kumar K Kiran , U C Sampritha , Sridhar Sriya
Published: January 2022

To study the prevalence, types and demographic profile of traditional eye medicine (TEM) use among corneal ulcer patients presenting to a tertiary eye care centre in South India.

A cross-sectional study conducted on 432 new corneal ulcer patients at a tertiary eye care centre in South India from September 2018 to July 2019. Data collected included demographic profile such as name, age, sex, occupation, income, rural/urban residence, type of TEM use.

Of the 432 new corneal ulcer cases, 32 used TEM. Most TEM users belonged to the age group 40- 60 years (n= 20; 62.5%). There was no difference in sex distribution. Majority of TEM users in our study resided in rural areas (n= 30; 93.75%), were involved in agriculture as occupation (n=28, 87.5%) and belonged to the lower socioeconomic status n=31(96.88%) as per Kuppuswamy classification. Profile of TEM used ranged from plant extract (n= 14; 43.75%), tongue cleaning (n= 5; 15.63%), oil (n= 7; 21.87%), breast milk (n= 4; 12.5%) and ash (n= 2; 6.25%).

Use of traditional medicine is a prevalent practice in the study population. These findings offer a better understanding of health seeking behaviour of the study population which will lead to better planning, implementation and targeting of preventive and promotive eye services and awareness programmes.
Cómo sanar un mundo herido: el poder del arte como motor de transformación social en la era pospandémica
Authors: Bilbao Tatiana , Camnitzer Luis , Ciancio Cecilia , Cozier Christopher , De la Garza Amanda , Dudamel Gustavo , Hanono Analía , Huffmann Carolina , Jarpa Voluspa , Landry Charles , Lastra Matías , Madoff Steven Henry , Millán Ana María , Noorthoorn Victoria , Ottone Ernesto R. , Reyes Manuela , Sáez de Ibarra María Belén
Published: January 2022

Esta publicación reúne ensayos de reconocidos líderes culturales, artistas, economistas, urbanistas, arquitectos y tecnólogos de la región, que abordan temas tales como el rol de las instituciones culturales en reimaginar comunidades; los artistas y su capacidad de reacción en tiempos de crisis; el futuro de nuestras ciudades y sus adelantos tecnológicos ante los avances del trabajo y el aprendizaje remoto, el aislamiento y las nuevas plataformas de comunicación y movilidad. Todos ellos participaron de la cumbre virtual Cómo sanar un mundo herido realizada por el Banco Interamericano de Desarrollo en abril de 2021. Es parte de los esfuerzos realizados por el BID en su compromiso por facilitar vías innovadoras de control y recuperación ante la pandemia del coronavirus. En línea con la Visión 2025, para impulsar la recuperación en América Latina y el Caribe, esta publicación reflexiona sobre cómo el arte y la cultura pueden proporcionar un espacio para sanar, reencontrarse, colaborar y proponer soluciones a los desafíos del desarrollo.
Readiness and Stakeholders Influence for Halal Logistics Practices Implementation towards Supply Chain Performance
Authors: Mubin Najaa Abd , Rahman Azmawani Abd , Kamarulzaman Nitty Hirawaty , Yusof Raja Nerina Raja
Published: January 2022

Halal industry is expanding worldwide, and it requires strong supply chain management to enhance halal business efficiency and preserve credibility through halal logistics process. However, studies on halal logistics remain limited and isolated. Thus, this study aimed to understand the impact of stakeholders on halal logistics practices among Malaysian halal-certified manufacturers. The primary objectives of this study are to examine the underlying dimensions of halal logistics practices, investigate the level of halal logistics practices, investigate the extent of stakeholders' influence on halal logistics practices, and explore the relationship of halal logistics practices towards supply chain performance. Based on the data collected through a questionnaires survey from 270 managers from halal-certified manufacturers, SPSS and SmartPLS were used to test the hypotheses. The findings of the study indicated that operational dimensions are the most practiced dimensions of halal logistics amongst firms. Meanwhile, competitors, government, NGOs, community media and society, and customers significantly influence the adoption of halal logistics practices. Importantly, halal logistics practices are positively related to supply chain performance. This study has extended the feasibility of stakeholder theory in the sense of halal logistics to the scope and comprehensiveness of stakeholders. The outcome of this study provides important implications to both academics and practitioners, particularly in the halal industry.
Bioindicators of Behavior and Regeneration of a Caatinga Area in the Brazilian Semi-Arid - A Review
Authors: Da Costa Cassio Ricardo  Goncalves , Silva Marcos Gomes da , Da Costa Carlos Antonio  Gonçalves , Da  Cunha Rayane Sley Melo , De Sousa Marcia Mayara , de Sousa Maria Vanessa  Pires , Maia Linhares Anne Carolline , Silva Sonaria de Sousa , Marques Ailson de Lima , Moura Debora Coelho de
Published: January 2022

Studies that allow the understanding of the nutrient cycling processes and maintenance of soil fertility in the caatinga biome are necessary to assist in the proposal of possible management forms, in view of the sustainability of this ecosystem, to provide data in an area of knowledge the quantification of glomalin can be a good indicator of changes caused by the use of the soil and, in turn, therefore, it can become a good indicator of its recovery because it is correlated with important attributes of the soil. In addition to providing data of this process for a better understanding of the soils of the country, a study on this subject will also contribute with a new database for global monitoring. Research that can follow the regeneration rate of Caatinga forests in the Semi-arid will allow the development of models relating to several variables, not currently available for the semi-arid tropical region.
Fear of Medical Staff: The Importance of Stigmatization during the COVID-19 Pandemic: Letter to the Editor
Authors: Bagheri Sheykhangafshe Farzin , Sadeghi Chookami Elnaz
Published: January 2022

Introduction: During the COVID-19 pandemic, although hospital staff cared for patients, they were recognized in the community as an asymptomatic carrier and people were afraid and anxious about them. To the extent thateven the families of hospital staff experienced this social stigma, and many people cut off contact with them. In addition to the stigma that medical staff received from people during the COVID-19 pandemic, many people were stigmatized and feared that as an asymptomatic carrier they would endanger the health of their families and those around them. For this reason, they tried to limit social communication and be more present at home and at work. Hospital staff were among the first to deal with the deadly virus and relinquish their physical health. Many nurses and physicians stay awake for long hours to save the lives of patients with COVID-19. Unfortunately, we have seen people fear and avoid the hospital staff, which has led to increased burnout and depression in the medical staff. For this purpose, it is necessary to take measures to socially motivate the medical staff of hospitals by the Ministry of Education and Health.
Cytotoxic and pro-apoptotic Effects of Spirulina Platensis Extract on PC-3 Prostate Adenocarcinoma Cell Line
Authors: Reisi Mohammad , Rouhi Leila , Khashei Varnamkhasti Khalil
Published: January 2022

Introduction: Prostate cancer is one of the most common cancers among men, with an increasing incidence and mortality rate. In the present study, cytotoxic and pro-apoptotic effects of spirulina platensis extract on PC-3 prostate adenocarcinoma cell line were investigated.
Methods: In the present experimental study, the PC-3 prostatic cancer cells were treated in four experimental with 400, 200, 100 and 50 μg / ml extract of spirulina and incubated at 24 and 48 hours. Cytotoxicity was analyzed by MTS kit (3-(4, 5-Dimethylthiazol-2-yl)-5-(3-Carboxymethoxyphenyl)-2-(4-Sulfophenyl)-2H-Tetrazolium, Inner Salt) and apoptosis was analyzed by flow- cytometry using an Annexin V-FITC/PI kit according to the manufacturer protocol in both times. Statistical analysis was accomplished by ANOVA and Duncan tests using FlowJo and SPSS 16 software.
Results: In the experimental groups treated with extract of spirulina, the viability of the cells showed a decrease compared to control group, while this decrease was more noticeable in the experimental group of 100 μg / ml at both incubation times (<0.0071).Increased incidence of apoptosis was significantly higher in the experimental groups than the control group. However, this increase was significantly higher than the control group at concentrations of 200 μg / ml in 24h incubation time (Ƥ < 0.0331) and 100 μg / ml of 48h incubation time (Ƥ < 0.0502).
Conclusion: Extract of Spirulina at specific concentrations reduced cell growth and induced apoptosis in PC-3 prostatic cancer cells. Evidence suggests that spirulina can be used as an anticancer drug for the treatment of prostate cancer.
Evaluation of Knowledge and Practice of Yazd General Practitioners about Shade Selection of Fixed Dental Prosthesis in 2019
Authors: Hatami Mahnaz , Hosseini Yekani Amene , Vaez Kazem
Published: January 2022

Introduction: The color matching of dental restorations is effective in the beauty of the smile and a dentist should be familiar with the subject of color and light to make a beautiful and natural prosthesis. The aim of this study was to investigate the knowledge and practice of general dentists in Yazd City about the choice of fixed prosthesis color in 2019.
Methods: This was a descriptive-analytical cross-sectional study in which all the general dentists in Yazd City were included in the study by census. Data were collected in the field through a valid and reliable questionnaire containing 11 knowledge questions and 17 performance questions. Data were analyzed by SPSS software version 24 using t-test and ANOVA (α <0.05).
Results: 150 dentists with a mean age of 39.14 ± 7.96 were studied in this study. The mean score of knowledge was 26.5 ± 3.32 out of 33 points. Mean knowledge score was not statistically significant with age, sex and dental work experience (P >0.05), but was associated with participation in retraining courses (P = 0.046). 79% of participants used brossage and prophylaxis before choosing a color, 31% used sunlight to choose a color, and 37% used the color of adjacent teeth as a color choice.
Conclusion: The knowledge of general dentists in Yazd City in choosing the color of fixed prostheses was at a good level and the performance was relatively good. Participation in retraining courses had led to an increase in dentists' awareness in this field.
Evaluating Mirna-222 Expression Level and Its Association with AMH for Early Diagnosis of Pcos-Like Symptoms in Epileptic Patients Plasma Treated with Sodium Valproate: A Case – Control Study
Authors: Rajabi Mahya , Miresmaili Seyed Mohsen , Montazri Fatemeh , Nasresfahani Mahsa , Zieai Seyed Jalal , Kalantar Seyed Mehdi
Published: January 2022

Introduction: Epileptic neurological disorder, which is controlled with medications such as sodium valproate (one of the treatment priorities for the patients with epilepsy). Polycystic ovary syndrome (PCOS) is one of complication of sodium valproate. Ovulation in PCOs Patients is disrupted, resulting in serious complications, including endometrial hyperplasia with typical and atypical forms, increased the risk of endometrial endometrial cancer, diabetes mellitus, and decreased fertility rates. This study, in accordance with bioinformatics studies and other studies based on the association of miRNA-222 with genes involved in PCOs and hyperandrogenism, was designed to evaluate the association of PCOs in the patients treated with sodium valproate by simultaneously comparing the AMH factor and miRNA-222 marker at specific time periods.
Methods: In this case-control study, 33 women with epilepsy before and after use the drug were selected based on inclusion and exclusion criteria. After blood sampling, their plasma was isolated. According to the instructions of the Total RNA extracted kit , cDNA synthesized and miRNA-222 expression was evaluated by RT-qPCR technique and statistical analysis was performed by SPSS 23 software, T-test and ANOVA tests.
Results: The results of statistical tests such as T-test and ANOVA test (done with SPSS software) which showed a significant difference (p<0/01) between the mean expression of mir-222 and AMH in the patients before treatment compared to 3 month after treatment. The results of Pearson correlation test showed that the increase in AMH is directly related to the decrease in miRNA-222 expression (p<0/01).
Conclusion: According to the results of the present study, in order to better control the possible side effects of the drug and possibly timely drug change and early diagnosis of PCOs (PCOs‌-like symptoms), evaluation of miRNA-222 expression changes can be used at the same time with AMH assay.
Expression Changes of the FOXE1 and Lncrna PTCSC2 Expression in Tumor Tissues Compared with Normal Tissues in Patients with Colorectal Cancer
Authors: Ghani Dehkordi Marzieh , Peymani Maryam
Published: January 2022

Introduction: In recent studies, methylation of FOXE1 in colorectal cancer has been reported as a diagnostic biomarker. In this study for the first time, the expression of FOXE1 and PTCSC2 in colorectal cancer was investigated and their expression patterns in two healthy and tumor tissues of patients were compared.
Methods: In this study, 40 tumor tissues with colorectal cancer and 40 adjacent normal samples were collected. Total RNA was extracted and cDNA synthesis followed. Then, the specific genes for lncRNA PTCSC2 and FOXE1 were amplified. The results were statistically analyzed by Graph Pad Prism software and a T-test was used to compare the expression levels of lncRNA PTCSC2 and FOXE1 in the patients and healthy group; p-value less than 0.05 was considered significant difference criteria.
Results: In this study, the FOXE1 expression level was significantly decreased in tumor tissue (p-value = 0.005), whereas the lncRNA PTCSC2 expression level in tumor tissue was not significantly changed (p-value = 0.65). In addition, the expression levels of FOXE1 and lncRNA PTCSC2 did not show a significant relation with disease progression and age of the patients. ROC curve for changes in FOXE1 and lncRNA PTCSC2 expression showed that theFOXE1 gene could be a relatively appropriate independent variable (p-value = 0.03) to differentiate between the two study groups.
Conclusion: According to the results of this study, changes in FOXE1 gene expression were significantly reduced in tumor samples and can be used as a biomarker in tumor diagnosis in colorectal cancer.
In vitro Anti-inflammatory Evaluation of 6-Thioguanine and 6-Hydroxy-2-Mercaptopurine as A Potential Treatment for Rheumatoid Arthritis
Authors: Nordin Nurul Syuhada , Keong Yong Yoke , Md Tohid Siti Farah , Md Zain Zetty Nadia , Hakim Muhammad Nazrul
Published: January 2022

BACKGROUND: Eventhough 6-Mercaptopurine act as a major drug for rheumatoid arthritis (RA) treatment, however, its toxicity become a limitation. Therefore, this current study investigated whether 6-hydroxy-2-mercaptopurine (6H2MP) and 6-thioguanine (6TG) compounds are purine nucleoside analogues as a potential treatment of RA. The objective was to evaluate the therapeutics effects, especially the anti-inflammatory potential of 6H2MP and 6TG in the lipopolysaccharides (LPS)-induced RAW264.7 cells and phorbol myristate acetate (PMA)-induced HIG-82 cells.METHODS: Macrophage cells (RAW264.7) and rabbit synoviocytes (HIG-82) cells were induced using LPS and PMA to evaluate the anti-inflammatory potential of 6H2MP and 6TG. The cytotoxicity assessment was done by using MTT assay, while enzyme-linked immunosorbent assay (ELISA) was used to determine the anti‑inflammatory potential, including tumour necrosis factor (TNF-α), interleukins (IL-1β, and IL-6).RESULTS: Upon LPS-induced, RAW 264.7 macrophages demonstrated that 6H2MP and 6TG could suppress the production of nitric oxide (NO) in vitro. The half-maximal inhibitory concentration (IC50) value of 6TG and 6H2MP were 10.73 and 13.31, respectively. Further studied in PMA-induced HIG-82 synovial fibroblast cells showed that 6H2MP and 6TG also suppressed the release of NO, Prostaglandin E2 (PGE2), and inflammatory cytokines such as TNF-α, IL-1β and IL-6. The 6TG is more effective to reduce inflammatory reactions compared to 6H2MP, by the lower dose needed compared to 6H2MP in all experiments except in PGE2.CONCLUSION: The inhibition of inflammatory mediators is an important mechanism by which 6TG and 6H2MP may alleviate pain and articular inflammation. These results indicated that 6H2MP and 6TG are effective candidates for ameliorating inflammatory-associated complications.KEYWORDS: anti-inflammatory, HIG-82 cells, RAW264.7 cells, 6-Thioguanine, 6-Hydroxy-2-Mercaptopurine