bluuebunny/crossref_metadata_2025 huggingface dataset:
Duas mulheres, dois livros: narrativas femininas acerca da campanha “De Pé no Chão se Aprende a Ler”
Authors: Santos Alessandra Maria dos , Barreto Raylane Andreza Dias Navarro
Published: September 2024

A despeito das tentativas de omitir a presença feminina na história, ao ter oportunidades, as mulheres não apenas revelam suas participações, mas também seus pensamentos e percepções. Por isso, neste artigo, pretendemos analisar duas narrativas femininas acerca da campanha de alfabetização “De Pé no Chão Também se Aprende a Ler”, que ocorreu na cidade de Natal, no Rio Grande do Norte, no período de 1961 a 1964. Por meio de uma pesquisa bibliográfica e documental, com análise de relatórios, jornais e materiais didáticos relacionados à campanha – e com o auxílio da metodologia da história oral – realizamos uma investigação sobre as narrativas da referida campanha de alfabetização, especialmente nas obras 1964: aconteceu em abril e Memórias da Campanha “De Pé no Chão Também se Aprende a Ler”. Para além dos dados da campanha, esses livros revelam aspectos biográficos das narradoras. Tais obras foram produzidas, respectivamente, por Mailde Pinto Galvão (1925 – 2013) e Margarida de Jesus Cortez (1930 –). As discussões teóricas da História Cultural (Chartier, 2002) e da História das Mulheres (Perrot, 2005; 2007) guiaram a compreensão dos dados, os quais indicam que, bem mais que compor o conjunto bibliográfico sobre a educação popular, os livros analisados compreendem a perspectiva feminina. Conclui-se que as obras, enquanto registros históricos, desvelam a intenção das autoras de explicitar seus pontos de vista acerca dos movimentos populares da educação, bem como demonstram suas subjetividades e a presença feminina na produção historiográfica.
Sztuka ma znaczenie
Authors: Rode Dagmara , Składanek Marcin , Ożóg Maciej
Published: September 2024

Tom ofiarowujemy Panu Profesorowi Ryszardowi W. Kluszczyńskiemu jako Jego uczniowie i uczennice, współpracownicy i współpracownice, przyjaciele i przyjaciółki. Książka ta stanowi formę podziękowań za intelektualne stymulacje, motywacje do eksplorowania twórczych działań oraz nade wszystko za naukowe inspiracje, jakie Mu zawdzięczamy. Trudno bowiem znaleźć osobę badającą filmową awangardę, sztukę wideo, a szczególnie sztukę nowych mediów i kulturę cyfrową, która nie odnosiłaby się do zaproponowanych przez Profesora ujęć, konceptualnych schematów i teoretycznych konstruktów lub w inny sposób nie czerpała z Jego dorobku – bogatego i ważnego dla współczesnych dyskursów kulturoznawczych. Tematyczne zróżnicowanie publikacji dowodzi, iż analizy sztuki i kultury nowych mediów – jakkolwiek ustanawiają węzłowy i najbardziej doniosły obszar refleksji Profesora – nie wyczerpują Jego zainteresowań oraz poszukiwań badawczych.
Ze Wstępu
Szkice z metodologii językoznawstwa i filozofii języka
Authors: Stalmaszczyk Piotr
Published: September 2024

Niniejsze szkice podejmują problematykę splotu językoznawstwa i filozofii języka, ze szczególnym zwróceniem uwagi na dokonania generatywizmu w językoznawstwie (w duchu Noama Chomsky’ego i Raya Jackendoffa) oraz analitycznej filozofii języka (nawiązującej do tradycji sięgającej Gottloba Fregego, Ludwiga Wittgensteina i Bertranda Russella).
Pierwszy rozdział przywołuje trylemat Gorgiasza i wskazuje na jego konsekwencje dla typologii nauk oraz dla zrozumienia uniwersalności języka. Po omówieniu zagadnienia postępu w filozofii, w drugim rozdziale przedstawione zostaje pojęcie paradygmatu i jego użyteczność w naukach humanistycznych i społecznych, a przede wszystkim w językoznawstwie. Paradygmat jest tu postrzegany jako sposób porządkowania i opisywania świata. Kolejne rozdziały poświęcone są paradygmatom językoznawstwa generatywnego (zwłaszcza przejściu od paradygmatu formalnego do mentalistycznego), podstawowym pojęciom z zakresu filozofii języka i językoznawstwa, a także rozwojowi współczesnej pragmatyki. Dalsze rozdziały proponują rozszerzenie semantyki pojęciowej o element pragmatyczny, a także elementarną semantykę kategorialną dla predykacji.
Pracę zamykają uwagi na temat rozszerzenia pola badań w kognitywno-analitycznej tradycji filozofii nowożytnej. Jednym z celów książki jest historiograficzny i porządkujący przegląd wybranych idei i teorii, co pociąga za sobą obfitość cytatów i omówień literatury źródłowej, a także obszerna końcowa bibliografia (ze szczególnym uwzględnieniem istotnych, a nierzadko wymagających przypomnienia, pozycji w języku polskim). Tak obszerna bibliografia pozwala również na umieszczenie prowadzonych rozważań w odpowiednim kontekście historycznym i metodologicznym.
Educational Evaluation Management In The Productive Learning Assessment System In Vocational Schools Or Madrasah Aliyah
Authors: Hidayat Reza , Hanif Mamun
Published: September 2024

Educational evaluation management in the productive learning assessment in vocational high schools or vocational madrasah aliyah is an integral part of effective vocational education. The main aim of this research is to evaluate the productive learning assessment system in the context of vocational education in vocational high schools and vocational madrasah aliyah. The method used in this research is descriptive qualitative using library sources such as books, journals, and policy documents because this method is an effective alternative for conducting research related to several vocational high schools and vocational madrasas to gain a deeper understanding of system implementation. productive assessment. The research results show that there are still several challenges in the productive assessment system, including openness in communication of assessment criteria and weights, as well as varying understanding of assessment guidelines. However, the evaluation also revealed best practices that have led to improvements in the assessment of productive learning. These results can be a basis for further improvements in the productive learning assessment system in vocational high schools and vocational madrasah aliyah, with a focus on improving the quality of vocational learning that is relevant and responsive to the demands of the job market.
Diagnóstico de calidad de los resúmenes de tesis de maestría en enfermería
Authors: Ramírez-Hernández Cynthia , González Juárez Graciela , Ponce-Gómez Gandhy
Published: September 2024

Objective: Analyze the structure dimensions of the summary and bibliographic references in the quality of the theses of graduates from 2015 to 2020 of the master's degree in Nursing from the National Autonomous University of Mexico.
Materials and methods: Quantitative, descriptive and analytical research. The non-probabilistic sample consisted of 96 master's level theses from five generations of graduates 2015-2020. The instrument is made up of 30 items, it was adapted to the postgraduate context and was validated by experts in terms of clarity in the wording, congruence with the dimension to be assessed and relevance. A pilot study was carried out in a population similar to that of the study (14 postgraduate theses). in the five dimensions considered in the scale. Spearman's Correlation was used to establish a relationship between the dimensions and the quality of the thesis summary. The statistical package SPSS version 21 was used.
Results: The correlations obtained are positive in all cases. The content and organization dimension presents a greater correlation with those of results and methodology and the strongest with the bibliographical references with respect to the other dimensions. The methodology dimension obtained greater significance with results and discussion. The dimension of results with that of methodology and that of content and organization. The discussion dimension with the dimensions of results and methodology.
Conclusions: The diagnosis made it possible to identify that the summary is essential to make visible the production of the Master's theses in Nursing in scientific databases. The clear and approved structure of the abstracts and bibliographical references is an important criterion in the self-evaluation of the program.
Keywords: Programs Evaluation; Nursing Evaluation Research; Educational Evaluation; Educational Measurement.
Causes générales de l'évolution de l'économie forestière gabonaise
Authors: Biraud J.
Published: September 2024

La vie économique de la République Gabonaise dépend encore aujourd'hui presque entièrement de la forêt, malgré les possibilités offertes par les produits miniers. Le bois de Gabon (Aucoumea) constitue la principale ressource forestière de la République gabonaise mais les stocks de cet arbre doivent être protégés, gérés et restaurés. Entre les deux guerres mondiales, une " 2ème zone " située en amont des endroits où les fleuves cessent d'être navigables a été judicieusement mise en réserve. L'exploitation de cette 2ème zone est maintenant ouverte. L'exploitation de la première zone a permis la production de ces 50 dernières années qui ont connu des crises sévères mais qui ont vu naître l'industrie du bois. Cette industrialisation doit être poursuivie dans le futur.L'auteur rappelle l'historique de l'exploitation forestière dans la première zone et souligne les problèmes posés par le développement de la deuxième zone.
La végétation forestière au Tchad
Authors: Grondard A.
Published: September 2024

Le territoire de la République du Tchad est situé dans les provinces botaniques septentrionales des forêts et savanes boisées d'une part et des formations steppiques et désertiques d'autre part.La végétation forestière comprend des éléments soudano-guinéens, sahélo-soudaniens et sahélo-sahariens, mais deux particularités géographiques sont à noter : la cuvette du Tchad et les chaînes de montagnes orientales, influencent nettement la répartition de cette végétation.On peut distinguer trois ceintures : au sud, la ceinture où prédominent les légumineuses et qui correspond au bioclimat soudano-guinéen ; au centre, la ceinture où prédominent les Combrétacée et qui correspond au bioclimat sahélo-soudanien ; et la ceinture nord, où prédominent les mimosées épineuses et qui correspond au bioclimat sahélo-saharien.
High porticoes: A phenomenon from Bolków, Kłodzko and Świdnica in a European context
Authors: Gliński Radosław
Published: September 2024

The aim of this article is to describe the phenomenon of high porticoes and related terraced walkways, motifs drawn from the broad issue of portico architecture. The author focuses on existing examples of high porticoes in Silesia and the Klodzko Land, or those evidenced by archival and archaeological documentation (Bolkow, Klodzko, Swidnica). Selected examples were analysed in terms of similarities in the solutions applied, but also differences in form and function. Archival research, analysis of preserved cartography and iconography, as well as documentation from architectural and archaeological surveys provide a general overview of this phenomenon.
Examples from Silesia and the Klodzko Land are furthermore presented in a European context. Similar examples can also be found in Poland (Bielsko-Biala, Przemysl), but also throughout Europe, i.e. in Italy (Brisighella), in Switzerland (e.g. Bern, Erlach, Avenches, Thun, Burgdorf) and in the United Kingdom (Chester).
The examples presented do not form an aesthetically and structurally homogeneous group. High porticoes seem to have been used particularly readily to bridge terrain differences in cities. However, their form, time of creation and legal aspect were always adapted to local conditions.
Evaluation of the Awareness of Sterilization and Disinfection Among Dentistry Faculty Students
Authors: Tekin Görkem , Çalışkan Gizem , Saruhan Nesrin
Published: September 2024

In recent years, the increase in diseases transmitted through blood and other body fluids has raised awareness about the implementation of sterilization and disinfection in the field of dentistry. The aim of this study is to examine the current practices and sensitivities of dental students regarding infection control, sterilization, and disinfection in the Oral, Dental, and Maxillofacial Surgery Clinic. The participating students were asked to answer a questionnaire consisting of 20 multiple-choice questions related to sterilization and disinfection. Questions prepared in the form of a Likert scale were classified with a 5-point scale and scored as "strongly disagree (1), disagree (2), undecided (3), agree (4), strongly agree (5). Data were analyzed using descriptive statistical methods, Shapiro-Wilk, Mann Whitney U and chi-square test. The study group consisted of a total of 150 students, with 71 (47.3%) being 4th and 79 (52.7%) being 5th grade students. The average age of the group was found to be 23.28 ± 1.12 years. When comparing the importance of handwashing when working with gloves and the disinfection of rotary instruments for infection control between 4th and 5th grade dentistry students, the results were significantly in favor of the 5th grade dentistry students (p<0.05). The average scores of the responses regarding sterilization and disinfection were 73.91 for the 4th-grade students and 76.93 for the 5th-grade students. When the scores were compared between the two grades, no statistically significant difference was found (p>0.05). It has been revealed that dentistry students need to be careful regarding sterilization and disinfection.
Personhood in Biblical and Patristic Thought A Journey from Natural to Spiritual Man
Authors: Hendi Hendi , Nagoya Rocky , Harefa Yaaro , Santosa Monica , Angelina Claudia , Sugianto Sugianto
Published: September 2024

This research challenges the materialistic view of humanity by offering a biblical and orthodox anthropological counter-narrative. It posits that human existence transcends mere matter, encompassing the body, soul, and spirit created in God's image and destined for divine communion (theosis). By examining key New Testament terms, such as natural, carnal, and spiritual man, through the lens of Patristic thought, particularly Gregory Palamas and Philokalia, this study reveals a dynamic transformation process from the natural to the spiritual man. This contrasts with the reductionist approach to materialism, demonstrating the richness and depth of the biblical and Orthodox understanding of human nature. This study contributes to a more comprehensive understanding of human identity and purpose by bridging the gap between biblical theology and contemporary philosophy, offering a fresh perspective on the complex interplay between the physical, spiritual, and divine aspects of humanity.
Alena Tensor and Its Possible Applications in Unification Theories
Authors: Ogonowski Piotr , Skindzier Piotr
Published: September 2024

Alena Tensor is a recently discovered class of energy-momentum tensors that provides mathematical framework in which, as demonstrated in previous publications, the description of a physical system in curved spacetime and its description in flat spacetime with fields are equivalent. The description of a system with electromagnetic field based on Alena Tensor can be used to reconcile physical descriptions. 1) In curvilinear description, Einstein Field Equations were obtained with Cosmological Constant related to the invariant of the electromagnetic field tensor, which can be interpreted as negative pressure of vacuum, filled with electromagnetic field. 2) In classical description for flat spacetime, three densities of four-forces were obtained: electromagnetic, against gravity, and the force responsible for the Abraham-Lorentz effect (radiation reaction force). Obtained connection of Einstein tensor with gravity and radiation reaction force, after transition to curvilinear description, excludes black hole singularities. There was obtained Lagrangian density and generalized canonical four-momentum, containing electromagnetic four-potential and a term responsible for the other two forces. In this description charged particles cannot remain at complete rest and should have spin, their energy results from the existence of energy of magnetic moment and the density of this energy is part of the Poyting four-vector. The distribution of charged matter was expressed as polarization-magnetization stress-energy tensor, what may explain why gravity is invisible in QED. 3) In quantum picture, QED Lagrangian density simplification was obtained, and the Dirac, Schrödinger and Klein-Gordon equations may be considered as approximations of the obtained quantum solution. Farther use of Alena Tensor in unification applications was also discussed.
Apocalyptic Proof of the Riemann Hypothesis with the Generating Function for Prime Numbers
Authors: Jalali Koutanaei Mojtaba
Published: September 2024

The Riemann zeta function plays a crucial role in number theory and its applications. The Riemann Hypothesis (RH) posits that zeros of other than the trivial ones are located on the line defined by the equation Re(s) =1/2. This paper introduces a novel and straightforward proof of the Riemann Hypothesis. The proof employs a standard method, utilizing the eta function in place of the zeta function, under the assumption that the real part is greater than zero. The equation for the real and imaginary parts of the Riemann zeta function (eta function) is completely separated. Initially, let with s= . The value of the real part is determined by solving the equation, and the process is repeated for identifying the potential roots shared by the two functions, a common value is obtained, leading to a =1/2, which represents the real part of the main root of the function ζ(s). By plotting the zeta function for the obtained a, it is determined that the function has a root only at a =1/2. In another analysis, by identifying the roots of the common potential between the two functions ζ(s) and ζ(1-s), a common value is obtained, which leads to a =1/2. This value represents the real part of the main root of the function ζ(s). Additionally, using a standard method and with the help of two functions ζ(s) and ζ(1-s), the real part of the root of the zeta function is obtained. To create a generator function for prime numbers in terms of b, one can solve the root of the zeta function where it equals one (i.e., and obtain a relationship between b’ and prime numbers. Giving the value of zeta equal to one and s' = a' + ib’, similar to zeta equal to zero, the roots are again placed on the line. Then, by using the zeta function defined by multiplying prime numbers, we arrive at a new meaningful relation between b’ and its corresponding prime number is obtained.
Do Fintechs Align More with Banks or Tech Firms?
Authors: Moro Visconti Roberto
Published: September 2024

This study investigates the strategic unity of fintech enterprises, assessing whether their characteristics bear greater resemblance to conventional banking institutions or technological corporations. Through the evaluation of operational functions, target demographics, business frameworks, stakeholder engagements, equity market dynamics, and empirical data, the analysis indicates that fintechs exhibit a closer alignment with technology companies. The inquiry uncovers significant lacunae in the prevailing scholarly discourse, particularly regarding the examination of fintechs’ fundamental attributes and their ramifications for strategic positioning. The results not only imply that fintechs are more akin to technology firms but also underscore the increasing convergence between fintechs and tech enterprises, propelled by the incursion of Big Tech and a heightened focus on sustainability. This implies an evolving financial landscape where traditional categorizations are progressively obscured. Our research is pivotal for comprehending and navigating this emergent terrain, which holds paramount importance for professionals operating within the financial and technological domains.
One-Year Effect of Elexacaftor/Tezacaftor/Ivacaftor Therapy on HbA1c Levels and Insulin Requirement in Patients with Insulin-Dependent Cystic Fibrosis-Related Diabetes: A Retrospective Observational Study
Authors: Bassi Marta , Strati Marina Francesca , Spiandorello Gaia , Scalas Marta , Cresta Federico , Calevo Maria Grazia , D'Annunzio Giuseppe , Castellani Carlo , Minuto Nicola , Maghnie Mohamad , Casciaro Rosaria
Published: September 2024

The main objective is to evaluate HbA1c levels in patients with cystic fibrosis-related diabetes (CFRD) after
one-year of therapy with elexacaftor/tezacaftor/ivacaftor (ETI). The secondary objective is to study the changes
in total daily insulin dose (TDD), pulmonary function and metabolism in this population. A retrospective sin
gle-center observational study was conducted at Regional Cystic Fibrosis Centre and Diabetology Centre of
IRCCS Istituto Giannina Gaslini. The observation period was divided into Time 0 (ETI treatment initiation),
Time 1 (T1 – 3 months of ETI therapy), Time 2 (T2 - 6 months of therapy) and Time 3 (T3 - 12 months of therapy).
Demographic and clinical data were collected. The results were then stratified by genotype (F508del in
homozygosity or heterozygosity). Twenty-eight patients with CFRD undergoing insulin therapy were included. TDD (IU) significantly decreased at T1 and T2, but not at T3, as for HbA1c. The number of hospitalizations and pulmonary exacerbations decreased significantly. We demonstrated both improvement in glycemic control (by means of HbA1c) and insulin requirement in insulin dependent CFRD patients after one year of only ETI treatment.
Dietary Patterns Correlate with Transition Readiness of Adolescents with Autism: A Pilot Study
Authors: de Jonge Lilian , Seidu Blessing
Published: September 2024

Despite extensive research on autism in children, much less attention has been given to the transition into adulthood. This study aims to address this gap by examining the dietary behaviors of young adults with autism during this critical transition period, highlighting the role of diet in enhancing their readiness for adulthood. Forty-seven participants (mean age 21.0 ± 1.1 years), both male and female, were involved in this study. Participants had various comorbidities, such as mood disorders, attention-deficit/hyperactivity disorder, depression, and anxiety disorders, for which they required medication. Dietary behavior was assessed using the Starting the Conversation: Diet survey, while transition readiness was measured with the Transition Readiness Sur-vey. T-test and regression analysis were utilized to evaluate the data. The results indicated that participants did not follow healthy eating habits, as reflected by the dietary scores (1.08 ± 0.07), and were not adequately prepared for adulthood, as shown by the transition readiness scores (3.19 ± 1.10). A statistically significant and negative correlation was found between dietary pat-terns and transition readiness (r = -0.51, p < 0.001), indicating an adverse relationship: transition readiness ratings decline as diet scores rise. Linear regression analysis revealed that dietary habits accounted for 26.20% of the variation in transition readiness, with the confidence interval for the coefficient of dietary habits being -2.89 to -0.95 (p = 0.002). The negative significant correlation between dietary scores and transition readiness scores shows that diet behavior significantly influences participants’ assessed readiness for transition.
Key Researchers: Structural Evolution of Co-Author Networks in Single-Balloon Enteroscopy (2000-2023)
Authors: Ogasawara Naruaki
Published: September 2024

Aim: This study aims to analyze the evolution of co-author networks in Single-Balloon Enteroscope (SBE) research from 2000 to 2023, using data from the Web of Science (WoS) Core Collection. The objective is to provide a structural overview of researcher collaborations in this specialized field, highlighting key contributors and the impact of international cooperation. Method: I conducted a co-author network analysis on 149 SBE-related articles indexed in the WoS Core Collection between 2000 and 2023. Using Python (Version 3.10.5) within the PyCharm development environment (Software Version 2022.1.3), I assessed macro-level indicators including network density, clustering coefficient, number of components, and average distance. Micro-level indicators such as degree centrality, closeness centrality, and betweenness centrality were also evaluated to understand the roles of individual researchers in the network.Result: The analysis revealed that the co-author networks in SBE research have evolved over the studied period, with varying degrees of connectivity and collaboration. From 2000 to 2009, the network showed moderate clustering but high fragmentation, with a few key researchers like Nista, Enrico C., and Spada, Cristiano playing central roles. In the 2010-2019 period, network density decreased, indicating expansion in the author pool but less frequent co-authorships. However, the clustering coefficient remained high, suggesting localized collaboration. Central figures such as Itoi, Takao emerged as influential in bridging network gaps. In the most recent period (2020-2023), network density moderately increased, reflecting improved collaboration. Key contributors included Tanisaka, Yuki, and Ryozawa, Shomei, who enhanced connectivity within the network. Despite these advancements, the network remained fragmented with isolated components throughout all periods. Conclusion: The co-author networks in SBE research have shown an overall increase in collaboration over the past two decades, with key contributors playing pivotal roles in connecting disparate groups. However, the persistent fragmentation suggests a need for more integrated efforts to enhance international collaboration. Understanding these network dynamics can inform future strategies for fostering global cooperation and advancing SBE research.
What about Land Uses in Mobility Hub Planning?
Authors: Pimenta Allan , Kamruzzaman Liton (Md)
Published: September 2024

Mobility hubs (MHs), where various transport modes converge, are increasingly being implemented as a key policy strategy to promote sustainable travel behavior. The existing literature is rich with proposals for various types of MHs and their suitable siting locations. However, studies comparing the role of land use patterns on the performance of different types of MHs are scarce. This study aims to fill this gap by analyzing transit patronage and active mode share as performance indicators of MHs. It compares the effects of land use patterns on the performance of different types of MHs classified by the nature of transport integration (e.g., train-tram-bus, train-tram, and train-bus) in different contexts (e.g., city center and suburb) in the Greater Melbourne Area, Australia. Results show that MHs, irrespective of their type, significantly enhance the use of both transit and active transport services compared to a unimodal train station, with maximum usage observed in a train-tram-bus hub, followed by train-tram and train-bus hubs. However, the underlying land use patterns significantly affect their performance. While the size of commercial land use consistently and positively influences transit patronage across MH types, certain land use patterns (e.g., intersection density, cultural centers, care facilities) exert their influence in specific types of MHs. These findings suggest that MH typologies should be designed in tandem with supportive land uses to maximize sustainable travel behavior.
Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic AntiGlutamic Acid Decarboxylase Autoantibody (GADA) Levels
Authors: Nolasco-Rosales Germán Alberto , Martínez-Magaña José Jaime , Juárez-Rojop Isela Esther , Rodríguez-Sánchez Ester , Ruiz-Ramos David , Villatoro-Velázquez Jorge Ameth , Bustos-Gamiño Marycarmen , Medina-Mora Maria Elena , Tovilla-Zárate Carlos Alfonso , Cruz-Castillo Juan Daniel , Nicolini Humberto , Genis-Mendoza Alma Delia
Published: September 2024

Latent autoimmune diabetes in adults (LADA) is characterized by the presence of glutamate de-carboxylase autoantibodies (GADA). LADA has intermediate features between type 1 diabetes and type 2 diabetes. In addition, genetic risk factors for both types of diabetes are present in LADA. Nonetheless, evidence about the genetics of LADA in non-European populations is scarce. This study aims to perform a genome-wide association study with a phenome-wide association study of LADA in a southeastern Mexican population. We included 59 patients diagnosed with LADA from a previous study and 3121 individuals without diabetes from the MxGDAR/ENCODAT database. We utilized the GENESIS package in R to perform the GWAS of LADA and PLINK for the PheWAS of LADA features. Nine polymorphisms reach the nominal association level (1x10-5) in the GWAS. The PheWAS showed that rs7305229 is genome-wide associated with serum GADA levels in our sample (p=1.84x10-8). rs7305229 is located downstream FAIM2 gene; previous reports associate FAIM2 variants with childhood obesity, body mass index, body adiposity measures, lymphocyte CD8+ activity, and anti-thyroid peroxidase antibodies. Our findings reveal that rs7305229 affects the GADA levels in patients with LADA from southeastern Mexico. More studies are needed to determine if this risk genotype exists in other populations with LADA.
Antioxidant Effect of a Plant‐Derived Extracellular Vesicles’ Mix on Human Skin Fibroblasts. Induction of a Reparative Process
Authors: Di Raimo Rossella , Mizzoni Davide , Aloi Antonella , Pietrangelo Giulia , Dolo Vincenza , Poppa Giuseppina , Fais Stefano , Logozzi Mariantonia
Published: September 2024

Plant-Derived Extracellular Vesicles (PDEVs) contain high levels of antioxidants, especially when deriving from organic. PDEVs from different vegetal sources has shown an increased antioxidant power, compared to PDEVs from single plants, suggesting a synergistic effect of the bioactives constitutively expressed in the PDEVs from single fruits. With this study we wanted to investigate the beneficial effects of a mix of PDEVs on human skin cells. We found detectable levels of Citric Acid, Ascorbic Acid, Glutathione, Catalase and SOD in a mix of PDEVs deriving from 5 different fruits (Grape, Red Orange, Papaya, Pomegranate and Tangerine). We then treated H2O2-conditioned fibroblasts with the mix of PDEVs. The results showed that the PDEVs ‘mix reverted the H2O2-induced redox imbalance, restoring the mitochondrial homeostasis, with a strong reduction of mitochondrial anion superoxide and increase of sirtuin levels. The antioxidant action was consistent with a wound repair on a lesion produced in a Fibroblasts’ monolayer. This result was consistent with an increased level of Vimentin and Matrix Metalloproteinase-9, whose expression is directly related to the efficiency of the reparative processes. These data support a beneficial role of PDEVs in both preventing and treating skin injuries, through their potent antioxidant and reparative activities.
Searching for a Novel HLA-Cw6-Linked Cardiometabolic Endotype in Psoriatic Disease
Authors: Queiro Rubén , González del Pozo Pablo , Alvarez Paula , Calleja Norma , Braña Ignacio , Loredo Marta , Pardo Estefanía , Burger Stefanie , Alonso-Castro Sara , Alperi Mercedes
Published: September 2024

Background and aims: In recent years, a possible connection between HLA-Cw6 and a distinctive cardiometabolic (CM) profile in patients with psoriatic disease (PsD) has been proposed, although there is still little support for this. Our aim was to further investigate this possible association by studying a large population of PsD patients. Methods: For this study, three different cohorts of patients with PsD were analyzed: two with a majority of cutaneous psoriasis, pooled n: 600, and a third with only psoriatic arthritis -PsA- cases, n: 340. Potential relationships between HLA-Cw6 and the different CM risk factors (hypertension, diabetes, obesity, dyslipidemia) were analyzed using univariate and multivariate regression models, while the final net effect was assessed using fixed- or random-effects meta-analyses, as appropriate. Results: In the PsA cohort, no association was detected between HLA-Cw6 carriership and any of the CM comorbidity factors. In psoriasis cohorts, after correcting for age, sex, disease duration and arthritis, HLA-Cw6 carriers reduced diabetes risk (OR 0.49, 95%CI: 0.26-0.91, p = 0.026). This latter effect was confirmed by a fixed-effects meta-analysis of the included cohorts (pooled OR: 0.50, 95%CI: 0.27-0.90). Conclusion: This work demonstrates a potential protective effect of the HLA-Cw6 allele on the risk of diabetes in PsD. Our findings together with those of others seem to confirm the existence of a novel HLA-Cw6-linked cardiometabolic endotype in this disease.
A New Tool for Extracting Static and Dynamic Parameters from [18F]F-DOPA PET/CT in Pediatric Gliomas
Authors: Mureddu Michele , Funck Thomas , Morana Giovanni , Rossi Andrea , Ramaglia Antonia , Milanaccio Claudia , Verrico Antonio , Bottoni Gianluca , Fiz Francesco , Piccardo Arnoldo , Fato Marco Massimo , Rosella Trò
Published: September 2024

PET imaging with [18F]F-DOPA has demonstrated high potential for the evaluation and management of pediatric brain gliomas. Manual extraction of PET parameters is time-consuming, lacks reproducibility, and varies with operator experience. In this study, we tested whether a semi-automated image processing framework could overcome these limitations. Pediatric patients with available static and/or dynamic [18F]F-DOPA PET studies were evaluated retrospectively. We developed a Python software to automate clinical index calculations, including preprocessing to delineate tumor volumes from structural MRI, accounting for lesions with low [18F]F-DOPA uptake. 73 subjects with treatment-naïve low and high-grade gliomas, who underwent brain MRI within two weeks of [18vF]F-DOPA PET, were included and analyzed. Static analysis was conducted on all subjects, while dynamic analysis was performed on 32 patients. For 68 subjects, the Intraclass Correlation Coefficient for T/S between manual and ground truth segmentation was 0.91. Using our tool, ICC improved to 0.94. Our method demonstrated good reproducibility in extracting static tumor-to-striatum ratio (p = 0.357), though significant differences were observed in tumor slope (p < 0.05). No significant differences were found in time-to-peak (p = 0.167) and striatum slope (p = 0.36). Our framework aids in analyzing [18F]F-DOPA PET images of pediatric brain tumors by automating clinical score extraction, simplifying segmentation and Time Activity Curve extraction, reducing user variability, and enhancing reproducibility.
Resilience, Anger, and Insomnia in Nurses after the End of the Pandemic Crisis
Authors: Pachi Argyro , Panagiotou Aspasia , Soultanis Nikolaos , Ivanidou Maria , Manta Maria , Sikaras Christos , Ilias Ioannis , Tselebis Athanasios
Published: September 2024

Nurses continue to experience intense psychological repercussions despite the official conclusion of the COVID-19 pandemic. In this cross-sectional study conducted after the end of the pandemic crisis, in nurses, we evaluated the levels and explored the associations between anger, insomnia and resilience. A total of 442 nurses participated in an online survey and were invited to state their work experience, gender and age and complete the self-report measures of the Dimensions of Anger Reactions-5 (DAR-5), the Athens Insomnia Scale (AIS) and the Brief Resilience Scale (BRS). 62.1% of participants presented with positive scores on the AIS, 41.5% displayed positive values on the DAR-5 scale, whereas 24.9% of nurses demonstrated scores indicative of low resilience on the BRS scale. Regression analysis revealed that 23.5% of the variance in the AIS scores can be attributed to the DAR-5 scores and 3% to the BRS scores. Mediation analysis confirmed the protective role of resilience contributing as a negative mediator in the DAR-5 and the AIS relationship. Screening for insomnia symptoms and anger issues among nurses after the end of the pandemic and implementing appropriate interventions is considered imperative to avoid long-term health consequences.
DRCCT: Enhancing Diabetic Retinopathy Classification with A Compact Convolutional Transformer
Authors: Touati Mohamed , Touati Rabeb , Nana Laurent , Benzarti Faouzi , Ben Yahia Sadok
Published: September 2024

Diabetic retinopathy, a common complication of diabetes, is further exacerbated by factors such as hypertension and obesity. This study introduces the Diabetic Retinopathy Convolutional Transformer (DRCT) model, which combines convolutional and transformer techniques to enhance the classification of retinal images. The DRCT model achieved an impressive average F1 score of 0.97, reflecting its high accuracy in detecting true positives while minimizing false positives. Throughout 100 training epochs, the model exhibited strong generalization capabilities, achieving superior validation accuracy with minimal overfitting. On a newly evaluated dataset, the model attained precision and recall scores of 96.93% and 98.89%, respectively, indicating a well-balanced handling of false positives and false negatives. The model's ability to classify retinal images into five distinct diabetic retinopathy categories demonstrates its potential to significantly improve automated diagnosis and aid in clinical decision-making.
Analysis of Associated Woody and Semi-woody Local Wild Species in Entre Ríos, Argentina: Exploring the Agricultural Potential of Hexachlamys edulis
Authors: Povilonis Ignacio Sebastián , Arena Miriam Elisabet , Alonso Marta , Radice Silvia
Published: September 2024

The loss of native forests in Argentina has been a concern, driven by factors such as agriculture expansion and urbanization. Therefore, understanding the conservation status of sampled populations and their adaptation to different plant communities is essential. This research focused on the heterogeneity analysis of the associated woody and semi-woody vegetation to Hexachlamys edulis (O. Berg) Kausel & D. Legrand, a species commonly known as "ubajay," in Entre Ríos, Argentina. The study aimed to record the species present in the populations, explore plant communities associated with H. edulis and identify other potentially useful agroforestry species, compare locations based on the similarity of accompanying species, and explain the conservation status of each population. Results revealed a total of 71 species belonging to 39 families. Myrtaceae family was the most relevant, particularly in terms of native species representation. The analysis of biodiversity indicators, including richness, Shannon index and dominance revealed variations among the studied sites. The anthropic indicator highlighted the impact of human activity, with Concordia showing a higher ratio of native to exotic species. Cluster analysis and ordination techniques revealed groupings of censuses from the same localities, indicating differences in vegetation composition between sites. Significant differences in species composition were found among the sampled populations. Overall, the study can serve as baseline information for future research on the dynamics of vegetation in these areas and on H. edulis studied species. Finally, these findings contribute to understanding how wild species like H. edulis adapt to different plant communities, which might be valuable for developing new agroecological approaches or identifying potential companion planting species in future agricultural systems.
Development of a Feasible and Efficient In Vitro Rescue Protocol for Immature Prunus spp. Embryos
Authors: Casanovas Maria , Claveria Elisabet , Dolcet-Sanjuan Ramon
Published: September 2024

Major factors affecting in vitro immature embryo rescue efficiencies from Prunus persica or P. armeniaca accessions, have been identified along with improving its economic feasibility. Three culture media, based on Woody Plant Medium (WPM) have been used depending on the embryo size. Embryos less than 5-mm-long were cultured in WPM supplemented with 1 mM BAP and 1 mM GA3, while embryos bigger than 5-mm-long were cultured in hormone-free medium, with or without vermiculite. Environmental in vitro culture conditions consisted of three phases, a (I) stratification at 4 C during a 3 to 5-month-long period in the dark, followed by (II) growth of germinated embryos at 14 C for 4-week-long period, with 12h light a day, which favors plantlet development, and finally (III) growth at 24 C, with 16h light a day, until the plantlets were moved to the greenhouse for acclimatization. Germination of smaller embryos, at the end of the phase I, ranged from 82.2% to 22.1%, for apricot and flat peaches, respectively, whereas for bigger embryos the germination varied from 97.4% to 53.2% for the same type of fruits. Embryo germination for peaches and nectarines ranged from 40.1% to 30.3% for smaller embryos, and from 91.9% to 64.0% for bigger embryos. Endo- and exophytic contamination, affecting from 7.4% to 52.9% of cultured embryos depending on the fruit type and conservation conditions, and the capacity to acclimate to soil conditions, ranging from 50.4% to 93.2%, were the two most important factors influencing protocol’s efficiency and economic feasibility. Considering the overall efficiencies, expressed as hardened plants transferred to field plots over clean uncontaminated embryo, values ranged from 55.8% for nectarines, 54.0% for peaches, 45.6% for apricot, and 23.3% for flat fruits. Addition of vermiculite to the culture medium significantly improved plantlet development, avoiding subculture to fresh medium when an extension of the phase III was required before acclimatization. Compared to laboratory glassware, use of food glass containers with air-permeable sealing film, along with vermiculite-containing medium significantly reduced costs, when handling the large number of embryos required for breeding programs.
A Review of Grouper Fisheries Management in the Southeastern and Caribbean U.S.: Challenges, Successes, and Future Directions
Authors: Coffill-Rivera Manuel E.
Published: September 2024

Groupers (Epinephelidae) are ecologically important mesopredators that support valuable fisheries across the globe. Many groupers display slow growth and maturity, high longevity, ontogenetic habitat shifts, spawning-related migrations and aggregations, and protogynous hermaphroditism, which make them susceptible to overexploitation. In this review, I synthesize available information related to the management of grouper fisheries across the southeastern and Caribbean U.S. I highlight current management challenges, such as managing multispecies reef fish fisheries with growing recreational fishing effort. I discuss management interventions with limited success, such as establishing marine protected areas to improve the populations of groupers that display protogynous hermaphroditism. I also highlight management successes, such as recovering historically depleted grouper stocks, and ecosystem-based considerations in grouper stock assessments. I discuss how climate change and anthropogenic effects are expected to affect groupers. Lastly, I provide examples of stakeholders involved in monitoring and management efforts directed at grouper stocks. The purposes of this review are to demonstrate the complexities of managing grouper fisheries and provide a road map for future research and conservation efforts into these economically and ecologically relevant fishes within and beyond the region.
Imaging Techniques for the Analysis of Blood-Brain Barrier and Gliovascular Unit Dysfunction
Authors: Golf Samantha , Munoz-Ballester Carmen , Heithoff Benjamin , George Kijana , Robel Stefanie
Published: September 2024

Proper blood-brain barrier (BBB) function is essential to maintain homeostasis keeping the central nervous system healthy. Disruption of the BBB has been described in nearly all neurological disease and injury contexts. Given the various physical and metabolic roles of the BBB and gliovascular unit (GVU), dysfunction should be assessed across multiple levels to pinpoint the exact nature of the impairment. Here we describe imaging techniques for evaluating various aspects of BBB and GVU integrity and function, tailored for use in mouse models with protocols for quantitative image analysis. These imaging techniques complement classical dye tracer experiments and reveal underlying molecular causes of BBB dysfunction.
Green Synthesis of Silver Oxide Nanoparticles from Mauritia flexuosa Fruit Extract: Characterization and Bioactivity Assessment
Authors: Guamán Linda P. , Zúñiga-Miranda Johana , Vaca-Vega David , Vizuete Karla , Carrera-Pacheco Saskya E. , Gonzalez-Pastor Rebeca , Heredia-Moya Jorge , Mayorga-Ramos Arianna , Barba-Ostria Carlos , Coyago-Cruz Elena , Debut Alexis
Published: September 2024

The increasing prevalence of multidrug-resistant pathogens (MDR), persistent biofilms, oxidative stress, and cancerous cell proliferation pose significant challenges in healthcare and environmental settings, highlighting the urgent need for innovative and sustainable therapeutic solutions. The exploration of nanotechnology, particularly the use of green-synthesized nanoparticles, offers a promising avenue to address these complex biological challenges due to their multifunctional properties and biocompatibility. Utilizing a green synthesis approach, Mauritia flexuosa Mf-AgONPs were synthesized and characterized exhibiting potent antibacterial effects against both non-resistant and MDR bacterial strains, with minimum inhibitory concentrations (MICs) ranging from 11.25 to 45 µg/mL. Mf-AgONPs also demonstrated significant antifungal efficacy, particularly against Candida glabrata, with a MIC of 5.63 µg/mL. Moreover, the nanoparticles showed strong biofilm inhibition capabilities and substantial antioxidant properties, underscoring their potential to combat oxidative stress. Additionally, Mf-AgONPs exhibited pronounced anti-tumor properties against various cancer cell lines, displaying low IC50 values across various cancer cell lines while maintaining minimal hemolytic activity at therapeutic concentrations. These findings suggest that Mf-AgONPs synthesized via an eco-friendly approach offer a promising alternative for biomedical applications, including antimicrobial, antifungal, antioxidant, and anticancer therapies, warranting further in vivo studies to fully exploit their therapeutic potential.
Compensation Function Observer-based Backstepping Sliding Mode Control of Uncertain Electro-hydraulic Servo Systems
Authors: Pan Changzhong , Wang Yanjun , Yang Simon X. , Li Zhijing , Xiao Jinsen
Published: September 2024

Observer-based control is the most commonly used method in the control of electro-hydraulic servo system (EHSS) with uncertainties, but it suffers from the drawback of low accuracy under the influence of large external load forces and disturbances. To address this problem, this paper proposes a novel compensation function observer-based backstepping sliding mode control (BSMC) approach to achieve high-accuracy tracking control. In particular, the model uncertainties, including nonlinearities, parameter perturbations and external disturbances are analyzed and treated together as a lumped disturbance. Then, a fourth-order compensation function observer (CFO) is constructed, which fully utilizes the system state information to accurately estimate the lumped disturbance. On this basis, the estimate of the lumped disturbance is incorporated into the design of an backstepping sliding mode controller, allowing the control system to compensate for the disturbance effect. The stability of the closed-loop control system under the CFO and BSMC is rigorously proven through the use of Lyapunov theory, which guarantees that all the tracking error signals converge exponentially to the origin. Comparative simulations are carried out to show the effectiveness and efficiency of the proposed approach, i.e., compared with PID and ESO-based BSMC methods, the tracking accuracy is improved by 99.93% and 99.76%, respectively.