bluuebunny/crossref_metadata_2025 huggingface dataset:
Generating Renewable Energy Based on the Circuit Approach
Authors: Ishiguri Shinichi
Published: June 2023

In this study, a new methodology based on the circuit approach is employed to obtain renewable electric energy. Although a voltage source and a current source generate voltage and current, respectively, they work only when they receive electric power, which is the product of voltage and current. However, this paper proposes a circuit with a voltage source, a current source and a super-condenser connected in series, in which the voltage source provides voltage for the current source and the current source provides current for the voltage source. Resultantly, electric power is generated both at the voltage and current sources, and the energy (i.e., the electric power) from the current source is converted to the charging energy in the super-condenser. Herein, we describe the method for charging the super-condenser using a voltage source and a current source. To confirm the abovementioned concept, we conducted experiments, and the energy was successfully produced, with high reproducibility. Finally, the brief mechanism for the energy conversion, a schematic method for reducing the capacitances of stored batteries, and the significance of this study are described.
Optimizing Marketing Decisions Through a Structured Decision-Making Model Based on Marketing Engineering Principles
Authors: Hajisafi Amir
Published: June 2023

Effective marketing decision-making benefits from a rigorous, data-driven process that systematically evaluates alternatives based on insights and analysis. This study develops and evaluates a 5-stage decision-making process model integrating marketing engineering principles aimed to optimize marketing decisions. An experiment randomized 150 participants into groups following either the proposed model or an unaided approach. Results indicate the model-following group achieved significantly higher ROI from marketing decisions (19.3% vs 16.4%) and employed key elements like customer segmentation, experimentation, and optimization to a greater extent. However, limitations including the experiment's scenario, self-report measures, and cross-sectional design constrain implications. Future research employing probability sampling, multiple decision contexts, longitudinal designs, manipulation checks, and objective metrics can further validate the proposed model. Overall, the study advances the understanding of how structured decision processes based on marketing engineering principles may optimize marketing decisions and outcomes.
Dampak Kebijakan Psbb terhadap Konsentrasi Pm2.5 di Indonesia
Authors:   Transmedia Digital, Dariyanto Erwin , Dariyanto Erwin ,   Transmedia Digital
Published: June 2023

Tujuan Penelitian ini untuk mengkaji dampak penerapan kebijakan Pembatasan Sosial Berskala Besar atau PSBB terhadap konsentrasi partikulat 2.5 (PM2.5). Periode pengamatan berlangsung dari 1 September 2019 hingga 31 Desember 2020 di Jakarta, Bandung, Yogyakarta, Semarang, dan Surabaya. Data diolah menggunakan model fixed effect least square dummy variable (LSDV) untuk menguji dampak kebijakan PSBB untuk mengurangi penyebaran COVID-19 pada konsentrasi PM2.5. Akibatnya, kebijakan PSBB berdampak signifikan terhadap penurunan PM2.5 menjadi 1.210 g/m3. Saat menguji dampak PSBB per level, dari 4 level PSBB, PSBB level 3 secara signifikan menurunkan konsentrasi PM2.5. Sedangkan PSBB level 1, PSBB level 2 dan PSBB level 4 dampaknya tidak signifikan. Penelitian lebih lanjut dapat dilakukan dengan melihat variabel jumlah kendaraan, ketegasan aparat dalam melaksanakan PSBB.
EFFECTS OF A TRADITIONAL CHINESE MEDICINE BASED DESENSITIZING GEL ON DENTIN HYPERSENSITIVITY
Authors: Wang Hui , Zhao Xiao , Ji Ping
Published: June 2023

Background and Objective: Bamboo salt, Calcined oyster, Drynaria fortunei, Indigo naturalis and Rehmannia glutinosa have been the main ingredients of many formulations in Chinese medicine for the treatment of toothache. This study evaluated the effect of a new desensitizing gel on dentin hypersensitivity (DH).

Materials and Methods: The desensitizing gel was prepared through a confirmed prescription of ingredients mentioned above and Poloxamer 407 (P407). The best concentration of P407 in prescription was screened according to the gelatin temperature of gel. Scanning electron microscopy (SEM) was used to evaluate the dentinal tubule occlusion of 32 human premolars under various treatments including the desensitizing gel. Randomized controlled clinical trials were conducted to evaluate the clinical effect of the desensitizing gel.

Results: The best concentration of P407 in prescription was 0.30g/ml. Scanning electron micrographs of the cross-sectional and longitudinal dentin surfaces revealed most of the dentinal tubules were occluded by sedimentation after desensitizing gel treatment, and significant difference existed compared to the control groups. Randomized clinical trials showed 173.72% and 270.07% mean relative improvements on tactile hypersensitivity at one-month and two-month follow-ups, and 54.11% and 90.91% mean relative reductions on air blast hypersensitivity at one-month and two-month follow-ups (p0.05).

Conclusions: Based on these findings, the desensitizing gel exhibits an obvious effect on dentinal tubule occlusion. Besides, data of the randomized clinical trials indicate a potential role for the desensitizing gel in managing DH.
THE EFFECTS OF AMINOETHOXYVINYLGLYCINE AND METHYL JASMONATE ON BIOACTIVE COMPOUNDS AND FRUIT QUALITY OF ‘NORTH WONDER’ SWEET CHERRY
Authors: Kucuker Emine , Ozturk Burhan
Published: June 2023

Background: AVG is an organic ethylene inhibitor. AVG treatments retarded the ripening process, increased fruit sizes and delayed loss postharvest

fruit flesh firmness by inhibiting ethylene. MeJA is a natural plant growth regulator and plays a regulatory role in various reactions. Apart from its role in fruit ripening, cell activities like anthocyanin and carotenoid synthesis and inhibitive role in aromatic formation, chlorophyll and lycopene production.

Materials and Methods: The present study was conducted to determine the effects of pre-harvest aminoethoxyvinylglycine (AVG) and jasmonate (MeJA) treatments on bioactive compounds, mineral nutrients and other fruit quality characteristics of ‘North Wonder’ sweet variety in 2011. sprayed on experimental trees at 125 mg L-1

dose in two different periods i.e. 3 weeks and 2 weeks before anticipated harvest date. MeJA was applied 3 week before the anticipated harvest date at a dose of 2240 mg L-1

.Results: MeJA significantly increased fruit weight and geometric mean diameter. AVG significantly decreased fruit weight and flesh/stone significantly increased L*, chroma and hue angle values. Effects of both AVG and MeJA on flesh firmness were also found to be significant.

While soluble solids concentration and pH values significantly decreased with AVG treatment, titrate acidity significantly increased. Both and MeJA treatments significantly decreased total phenolics (TP), total antioxidant capacity (TAC) and total anthocyanin (TA). Effects on such decreases in TAC and TA were more efficient than MeJA. While the effects of both AVG and MeJA on iron content were significant,

effects of only MeJA on nitrogen and phosphor contents were found to be significant.

Conclusion: Growth regulators significantly decreased bioactive compounds. AVG was more effective in such decreases than MeJA.
SIMULTANEOUS DETERMINATION OF FLAVONOIDS AND TRITERPENOIDS IN CYCLOCARYA PALIURUS LEAVES USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: Shang Xulan , Wu Zheng-Feng , Yin Zhi-Qi , Zhang Jian , Liu Zhi-Jun , Fang Sheng-Zuo
Published: June 2023

Background: Cyclocarya paliurus is an endangered plant endemic to China. The leaves of C. paliurus have been used in drug formulations and as ingredients in functional foods in China. The aim of this study was to develop an effective method to extract most of compounds and to extablish a simplified HPLC analytical method to determine the contents of major bioactive compounds simultaneously.

Materials and methods: High-performance liquid chromatography (HPLC) coupled with a photodiode array detector (PDA) was used for the simultaneous determination of the major flavonoids and triterpenoids in C. paliurus leaves.

Results: Ultrasonic extraction in 100% methanol for 30 min was adopted as the optimal extraction method for C. paliurus leaves. The separation conditions were optimized using a Phenomenex C18 ODS column (250 mm × 4.6 mm, 5 µm) with a mobile phase of acetonitrile and 0.02% formic acid and a detection wavelength of 205 nm. The validation data indicated that this new HPLC analytical method successfully quantified the provenance and seasonal variations of seven major compounds (three flavonoids and four triterpenoids) in C. paliurus leaves.

Conclusions: This study provides a novel and simplified approach to simultaneously determine the contents of major flavonoids and triterpenoids in C. paliurus leaves. Meanwhile, the results could promote the optimization of silvicultural systems for quality control of C. paliurus.
PHENOLIC CONSTITUENTS FROM SARCOPYRAMIS NEPALENSIS AND THEIR Α-GLUCOSIDASE INHIBITORY ACTIVITY
Authors: Tan Chao , Zuo Jiangcheng , Yi Xiaofang , Wang Peng , Luo Chunhua , Hu Yong , Yi Hong , Qiao Wei
Published: June 2023

Background: This study was carried out to fully investigate the phenolic chemical constituents of Sarcopyramis nepalensis and determine their α-glucosidase inhibitory activity.

Materials and Methods: S. nepalensis was extracted using the ultrasonic assistant extraction (UAE) method and further fractionated with petroleum ether (PE), chloroform (CHCl3), ethyl acetate (EtOAc) and n-butanol (n-BuOH), respectively. The active fraction was chromatographed on AB-8 macroporous resin column, silica gel column, Sephadex LH-20 column, RP-ODS column and semi-preparative HPLC column. The isolated phenolic constituents were identified by 1H-Nuclear Magnetic Resonance (NMR), 13C-NMR and mass spectral (MS) analyses and detected their α-glucosidase inhibitory activity by micro-plate.

Results: Ten phenolic constituents were isolated and identified from the active fraction of S. nepalensis. They were identified as isorhamnetin(1), quercetin(2), isorhamnetin-3-O-β-D-glucopyranoside(3), isoquercetin (4), astragalin(5),isorhamnetin-3-O-(6"-p-coumaroyl)-β-D-glucopyranoside(6),isorhamnetin-3-O-(6"-caffeoyl)-β-D-glucopyranoside(7), isoferulic acid(8) Caffeic acid(9) and ellagic acid(10). All of the phenolic compounds were assayed for their hypoglycemic activity against α-glucosidase in vitro. Compound 4, 6 and 7 showed promising α-glucosidase inhibitory activity with the IC50 values of 0.69 mg/ml, 0.56 mg/ml, 0.45 mg/ml, respectively.

Conclusion: Compounds 5-8 were isolated for the first time from S. nepalensis. This is the first report on the characterization of phenolic compounds and possible utilization of S. nepalensis for therapeutic intervention in type 2 diabetes.
ANTIMICROBIAL ACTIVITY OF CINNAMALDEHYDE, VANILLIN AND KIGELIA AFRICANA FRUIT EXTRACTS AGAINST FISH-ASSOCIATED CHRYSEOBACTERIUM AND MYROIDES SPP. ISOLATES
Authors: Chenia Hafizah Yousuf
Published: June 2023

Background: Members of the family Flavobacteriaceae exhibit intrinsic multi-drug resistance, which hampers their effective eradication. Phytochemicals are being explored as alternatives to the use of antimicrobial agents in aquaculture since they have growth-promoting, immune-stimulating, and antimicrobial properties.

Materials and Methods: The susceptibility of 36 Chryseobacterium and seven Myroides spp. isolates from salmon, tilapia and trout as well as 19 selected Flavobacteriaceae type strains to cinnamaldehyde, vanillin and four crude Kigelia africana extracts (ethyl acetate, dichloromethane, methanol and hexane), was assessed using disc diffusion assays and compared to standard antimicrobial agents, ampicillin and tetracycline using activity indices.

Results: Cinnamaldehyde (≥250 µg/ml) was the most effective (77. 8 – 100% susceptibility) while vanillin was the least effective with inhibitory activity only at 1000 µg/ml. The K. africana hexane extract (4 mg/ml) was the most effective, with only 11.3% of isolates displaying resistance, while 94.4% of isolates demonstrated resistance to ampicillin and 38.9% susceptibility to tetracycline. K. africana extract inhibitory efficacy decreased in the following order: hexane > ethyl acetate > dichloromethane > methanol. Cinnamaldehyde and K. africana EX 4 activity indices ≥ 1 were obtained for 83.3 - 97.2% and 25% of Chryseobacterium spp. isolates, respectively, relative to tetracycline.

Conclusions: Cinnamaldehyde and K. africana fruit hexane extracts are promising candidates to be tested for their efficacy in the treatment of Chryseobacterium/Myroides-associated fish infections. These phytochemicals might serve as environmentally-friendly, cost-effective alternatives to the use of antimicrobial agents in aquaculture farms, with a lesser chance of resistance development.
INFLUENCE OF CARDIOSPERMUM HALICACABUM LEAF EXTRACT ON MEMBRANE BOUND ENZYMES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Authors: Veeramani Chinnadurai , Al-Numair Khalid S. , Chandramohan Govindasamy , Alsaif Mohammed A. , Pugalendi Kodukkur Viswanathan
Published: June 2023

Background: Cardiospermum halicacabum L. has been proven scientifically to possess anti-inflammatory, antihyperglycemic, antioxidant, antiglycation, analgesic and antipyretic activities. It also has been used in Ayurveda and folk medicine for the treatment of rheumatism, fever and earache. Objective: In the present study, we investigated whether the Cardiospermum halicacabum leaf extract (CHE) can improve the membrane bound enzymes activity by streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ. The CHE was administered orally to normal and STZ-diabetic rats for 45 days. Results: There were a marked decrease in the activities of membrane bound phosphatases such as total ATPases, Na+/K+-ATPases, Mg2+-ATPases and Ca2+-ATPases in the erythrocytes and tissues of STZ-induced diabetic rats. Oral administration of CHE to diabetic rats significantly increased the activities of these enzymes towards near normalcy. Conclusions: Thus, the present study indicates that the beneficial role of membrane bound enzymes in STZ-induced diabetic rats. The antihyperglycemic, antioxidant and antihyperlipidemic properties of CHE (Veeramani et al., 2008; Veeramani et al., 2010) could be helpful to maintain the levels of membrane bound enzymes in STZ-induced diabetic rats showing the membrane stabilizing property of extract.
EFFECTS OF SUPPLEMENTING LACTIC ACID BACTERIA ON FECAL MICROBIOTA, TOTAL CHOLESTEROL,TRIGLYCERIDES AND BILE ACIDS IN RATS.
Authors: Zhimin Jin , Hong-bo Zhang , Xuehui Jia , Qian Yuan , Liga Tong , Yan Duan , Ye Jin
Published: June 2023

Background: Probiotics (LAB) are normal components of the intestinal micro-flora in both humans and animals and its ingestion in decreasing the risk of atherosclerosis. In addition, the potential health effects of LAB were investigated by monitoring changes in intestinal micro-flora and lipid metabolism in a rat model.

Materials and Methods: Rats were randomly assigned into four treatments and fecal samples were obtained on days 1, 3, 5, 9 and 14,to evaluate fecal micro biota, total cholesterol (TC), triglycerides (TG) and bile acids in rats (TBA).

Results: The results indicated that Lactobacillus plantarum strain L.p X3-2B increased fecal lactic acid bacteria(LAB) and Bifidobacterium while resisting the growth of harmful bacteria. Viable counts of LAB and Bifidobacterium reached 8 log cfu/mL after feeding for 14 days. Fecal pH in the control group was high in comparison with the treatments at all times. Treatment increased the excretion of triglycerides (TG), total cholesterol (TC) and total bile acid (TBA). The results indicate that LAB and Bifidobacterium induce a positive correlation with fecal TC, TG and TBA and a negative correlation with fecal Enterobacteriaceae, Enterococcus and Escherichia coli.

Conclusion: Lactic acid bacteria screened from Inner Mongolia native meat sausages in China had cholesterol-lowering effect.
ACTIVATION OF DIFFERENT CEREBRAL FUNCTIONAL REGIONS FOLLOWING ACUPUNCTURE AT BOT H TAIXIAND TAICHONG ACUPOINTS AND TAIXIACUPOINT ALONE: AN FMRI STUDY
Authors: Wang Y. J. , Zheng Y. , Zhang G. F. , Zhan J. P. , Wu C. X. , Zhang S. Q. , Ouyang H. L. , Li Z. P. , Chen J. R. , Qu S. S. , Chen J. Q. , Huang Y. , Tang C. Z.
Published: June 2023

Background: To explore the brain function regions characteristics of the acupoint combination, this study observed activity changes in the brain

regions of healthy volunteers after acupuncture at both Taixi (KI3) and Taichong (LR3) (KI3 + LR3) and KI3 alone using resting-state functional

magnetic resonance imaging(fMRI).

Methods: 30 healthy volunteers were randomly allocated into two groups, one group received acupuncture at KI3 and LR3, the other only

acupuncture at KI3, 15 cases in each group. All volunteers underwent resting-state fMRI of the brain 15 minutes before acupuncture, and which

the needle was retained in place for 30 minutes; 15 minutes after withdrawing the needle underwent a further session of resting-state fMRI. The

amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were used to analyze the changes in brain regions.

Results: The KI3+LR3 group compared with the KI3 group, the ALFF analysis indicated that the brain changes relatively concentrated in BA 2,

3, 7, 8, 9, 10, 18, 19, 20, 31, 32, 40, 46 and the cerebellum posterior lobe, the ReHo analysis indicated that the brain changes relatively

concentrated in BA 4, 6, 7, 10, 11, 18, 19, 20, 21, 22, 31, 40 and the cerebellum posterior lobe.

Conclusion: Based on this study, compared with acupuncture at KI3, acupuncture at KI3 + LR3 which could specifically influence BA 7, 10, 18,

19, 20, 31, 40 and cerebellum posterior lobe, which may be related to synergy mechanism of two acupoints combination treatment.
ASTRAGALOSIDE IV LIPOSOMES AMELIORATES ADRIAMYCIN-INDUCED NEPHRITIC SYNDROME IN RATS MING-GANG
Authors: Wei Ming-gang , He Wei-ming , Zhang Ling , Yan Zhao-wei , Yang Yan-Yu , Xiong Pei-Hua , Sun Wei
Published: June 2023

Background: Radix Astragali was one of the main composition of ‘Modified Danggui Buxue Decoction’ used for treatment of various kidney

diseases. Astragaloside IV was the active composition of Radix Astragali. Astragaloside IV liposomes were used for the treatment of

adriamycin-induced nephropathy (AN) rats. The aim of the study was to study the effect of astragaloside IV liposomes on AN rats, and to test

through regulating the expression of nephrin, integrins and integrin-linked kinase (ILK) in renal tissues.

Methods: The rats were given a single tail intravenous injection of adriamycin (6 mg/kg) within 1 weeks, and then divided into four groups

including normal, model, benazepril and astragaloside IV liposomes group. They were all orally administered dosage of benazepril and

astragaloside IV liposomes once daily for 8 weeks.

Results: Astragaloside IV liposomes significantly reduced the proteinuria of AN rats at 28, 42 and 56 days. astragaloside IV liposomes could

increase the mRNA and protein expression of nephrin, integrin α3, down-regulate the expression of ILK to alleviate the podocyte damage and

restore glomerular selective filtration function.

Conclusions: Astragaloside IV liposomes could enhance renal function and protect podocyte to ameliorate the adriamycin-induced nephritic

syndrome.
PHYTOCHEMICAL ANALYSIS OF CYRTANTHUS OBLIQUUS BULBS FROM THE INFORMAL STREET MARKET OF KWAZULU-NATAL, SOUTH AFRICA
Authors: Mahlangeni Nomfundo T. , Moodley Roshila , Jonnalagadda Sreekanth B.
Published: June 2023

Background: Cyrtanthus obliquus is a medicinal plant commonly known by the locals in South Africa as Umathunga. It is used in traditional South

African medicine for the treatment of scrofula, chronic coughs and headaches and is also used to prepare the popular decoction known as Imbiza.

Materials and methods: The secondary metabolites from C. obliquus bulbs were extracted using solvent extraction techniques, isolated using

column chromatography and identified using spectroscopic techniques. The antioxidant potential of the isolated compounds was determined by the

2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and the ferric reducing antioxidant potential (FRAP) assay.

Results: The extracts yielded four homoisoflavonoids, 5,7-dihydroxy-6-methoxy-3-(4ꞌ-methoxybenzyl)chroman-4-one, 5,7-dihydroxy-3-(4ꞌ-

hydroxybenzyl)chroman-4-one,5,7-dihydroxy-6-methoxy-3-(4ꞌ-methoxybenzylidene)chroman-4-one and 5,7-dihydroxy-3-(4ꞌ-

hydroxybenzylidene)chroman-4-one. An unusual 3-β-glucopyranosyl-22,27-dihydroxy-lanosta-8-ene was also isolated from the bulbs. The

antioxidant studies showed that 3-benzylchromanones have better activity than 3-benzylidenechromanones.

Conclusion: Four homoisoflavanones namely 5,7-dihydroxy-6-methoxy-3-(4ꞌ-methoxybenzyl)chroman-4-one; 5,7-dihydroxy-6-methoxy-3-(4ꞌ-

hydroxybenzyl)chroman-4-one and two 5,7-dihydroxy-6-methoxy-3-(4ꞌ-methoxybenzylidene)chroman-4-one; 5,7-dihydroxy-3-(4ꞌ-

hydroxybenzylidene)-chroman-4-one were obtained from Cyrtanthus obliquus.
CYTOLOGICAL EFFECTS OF PULSED ELECTROMAGNETIC FIELDS AND STATIC MAGNETIC FIELDS INDUCED BY A THERAPEUTIC DEVICE ON IN VIVO EXPOSED RATS.
Authors: Rodriguez de la Fuente Abraham Octavio , Heredia-Rojas Jose Antonio , Carranza-Rosales Pilar , Heredia-Rodriguez Omar , Lozano-Garza Gerardo , Zavala-Pompa Angel , Rodriguez-Flores Laura E.
Published: June 2023

Background: There is a trend towards the use of magnetic fields in medicine. Pulsed electromagnetic fields (PEMFs) technology was based

upon 20 years of fundamental studies on the electromechanical properties of bone and other connective tissues. More recently, these magnetic

fields have been used to treat several health conditions. There remains continuing concern that exposure to electromagnetic devices may cause

adverse effects. The aim of the present study was to investigate the cytological effects induced in rats exposed in a patented medical device that

uses PEMFs combined with static magnetic fields (SMFs).

Material and Methods: Thirty sexually mature 14-week-old male and female Sprague Dawley rats were distributed into three groups: (a) 5

males and 5 females (independently) exposed to PEMFs combined with SMFs, (b) animals treated with SMFs only, and (c) non-exposed

animals. Acridine orange fluorescent-staining micronucleus test and male germ cells analysis were performed according to standardized

techniques.

Results: A lack of evidence for alterations on micronucleus frequency, on polychromatic erythrocytes percentage, and on sperm counts and

morphological characteristics of male germ cells were found in mature rats exposed to PEMFs medical device compared to non-exposed

animals.

Conclusions: This study suggests that the applied magnetic field generated in a therapeutic device did not have any detectable cytotoxic or

genotoxic effect in exposed rats. In view of these findings and the contradictory reports in the literature, it is necessary to carry out more

research to help clarify the controversy concerning cytogenotoxic risk associated with therapeutic magnetic fields exposures.
SIJUNZI DECOCTION DEMOLITION PARTIES INHIBIT PROLIFERATION AND INDUCE APOPTOSIS OF HUMAN GASTRIC CANCER BGC823 SIDE POPULATION
Authors: Qian Jun , Xie Hui , Guo Chenxu , Sun Rui , Su Lin , Jia Jianguang , Jin Xin , Yu Dajun , Li Jing
Published: June 2023

Background: Comprehensive treatment combining with Chinese medicine has become the main therapeutic regimen of gastric cancer. Previous

evidence demonstrated SD can enhance the effect of chemotherapy in advanced cancer, especially in gastric cancer. In order to investigate the

anticancer mechanism of SD in gastric cancer, we observed the effects of SD parties (Ginseng, Atractylodes, Poria, Licorice) on proliferation and

apoptosis of SP of human gastric cancer BGC-823.

Materials and Methods: 1. BGC-823 side population cells were sorted through flow cytometry. 2. To detect the changes of proliferation of SP

and NSP before and after the intervention of serum containing SD parties using cck-8 method. 3. To detect the changes of cell cycle and

apoptosis of SP and NSP before and after the intervention of serum containing SD parties through flow cytometry. 4. To detect the effects of

serum containing SD parties on apoptosis-related proteins Bax and Bcl-2 of SP and NSP before and after the intervention by western-blot.

Results: It was found that four demolition parties serum treatments inhibited cell proliferation in a time-dependent manner. Compared with the

control group (normal saline treatment), there were increase in G1/G0 phase population of SP and NSP, and decrease in G2/M and S phase

population (P
Public participation and access to justice in environmental matters in Croatia
Authors: Stanicic Frane
Published: June 2023

Environmental protection is often achieved through participation in administrative procedures by the interested public in the form of interested parties. Such parties are able to participate in administrative procedures through which, for example, building permits and environmental permits are issued. In this manner, the public is able to challenge administrative decisions in front of first-instance and second-instance bodies in administrative procedure, and, subsequently, in administrative disputes in front of competent administrative courts. However, in many sector laws this opportunity is being bypassed by narrowing the possibility to participate in administrative procedure. Croatia is also a party to the Aarhus Convention, which guarantees the possibility of the public concerned (having only factual interest to prove) to participate in administrative procedures regarding administrative matters. Furthermore, the possibility to partake in spatial planning will also be analyzed in this paper, as spatial planning has a huge impact on the environment. Therefore, this paper will analyze the opportunities and challenges for public participation and access to justice in environmental matters in Croatia.
The Translingual Literacy Movement: Optimizing Multilingual Skills through Literature
Authors: Fatimatuz Zahro Diyan
Published: June 2023

This study addresses the underutilization of multilingual capabilities in Indonesia's educational system by introducing a translingual literacy movement, with literature serving as a principal tool. We utilized a systematic literature review (SLR) methodology, scrutinizing relevant publications from 2012-2022. The investigation drew from 15 sorted articles from international journals focusing on 'sastra', 'literasi', and 'translingual'. With Indonesia's rich cultural diversity, the potential for multilingual learning is significant, yet educational institutions have inadequately integrated language skills, often creating separate barriers for different languages. The translingual approach, rooted in progressivism, was explored to leverage language diversity as a resource rather than an obstacle, enabling students to better communicate and acquire useful knowledge for their self-development. Literature's role in facilitating this multilingual proficiency was emphasized, promoting imaginative and creative learning against traditional and conservative approaches. The implementation of this translingual literacy movement is expected to empower students to effectively use their multilingual abilities, fostering competitiveness in a global context. The study advocates for a reformed language learning approach, highlighting the need for proper literary resources and a conducive ecosystem to realize students' multilingual potential.Highlights: The importance of the translingual literacy movement in leveraging language diversity and optimizing multilingual abilities in Indonesia. The critical role of literature in fostering imaginative and creative learning, thus facilitating the translingual approach rooted in progressivism. The potential global competitiveness of students enhanced by effective utilization of their multilingual skills via the proposed translingual literacy movement. Keywords: Translingual Literacy, Literature, Multilingualism, Progressive Education, Language Diversity.
Distribution and Cocrystallization Coefficients of a Wide Range of Typomorphic Elements in Magnetite, Hematite, and Sphalerite in Hydrothermal Systems
Authors: Tauson V.L. , Lipko S.V. , Smagunov N.V. , Babkin D.N. , Belozerova O.Yu.
Published: June 2023

—Distribution of a wide range of elements in the systems with magnetite, hematite and sphalerite is studied by the method of thermogradient hydrothermal synthesis combined with internal fluid sampling at 450 °C temperature and 100 MPa pressure. The distribution and cocrystallization coefficients are determined; the literature and original data on these coefficients are summarized. The possibility of obtaining the reproducible data on elements distribution in the mineral − solution system in the occurrence of many typomorphic elements is substantiated. This considerably increases the experiment efficiency. A significant advantage of using cocrystallization coefficients rather than “conventional” distribution coefficients expressed by the ratio of the element concentrations in crystal and solution (fluid) is shown. The features of behavior and occurrence of elements in hydrothermal systems are provided with physico-chemical evidence, through application of cocrystallization coefficients. The examples of the behavior of typomorphic trace elements in sphalerite are considered, which support the theoretical analysis. The major (Fe, Mn, Zn and possibly Cu) and secondary (Ti, V, Al, and Co) components of ore-forming solutions are estimated according to the compositions of magnetite and hematite from hydrothermal ore deposits of various types. The similarity in compositions of magnetite and hematite does not prove their coformation from a single fluid, quite the reverse, and this fact indicates different compositions of fluids from which the minerals were deposited.
Temperature-responsive crystal dynamic accelerates sieving of propane/propylene mixtures
Authors: Huang Yuhang , Wan Jingmeng , Lu Zhiyong , Ge Kai , Pan Ting , Guo Yanan , Bai Junfeng , Jin Wanqin , Kitagawa Susumu , Duan Jingui
Published: June 2023

Soft nanoporous crystals with structural dynamics are among the most exciting of recently discovered materials. However, designing or controlling this system, which can recognize very similar gases, remains a challenge. Here we report a soft crystal (NTU-68) in which one-dimensional channel opening delicately expands and contracts ~4 Å at elevated temperature. A completely different adsorption model for propane (C3H8: kinetic dominance) and propylene (C3H6: thermodynamic preference) allows sieving of C3H8/C3H6 mixtures at 273 K (10 min·g-1), as well as boosted performance at 298 K (22 min·g-1). This is contrary to the general observation for adsorption separation, the higher the temperature, the lower the efficiency. Gas-loaded in-situ powder X-ray analysis and model calculations reveal that slight pore enlargement in the temperature response provides plausible traffic for C3H6 but remains constriction on C3H8. The finely controlled dynamic systems and efficient molecular recognition provide a new route for design of next-generation sieve materials.
Direct Prediction Of Intrinsically Disordered Protein Conformational Properties From Sequence
Authors: Lotthammer Jeffrey , Ginell Garrett , Griffith Daniel , Emenecker Ryan , Holehouse Alex
Published: June 2023

Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a range of functional roles. While folded domains are generally well-described by a single 3D structure, IDRs exist in a collection of interconverting states known as an ensemble. This structural heterogeneity means IDRs are largely absent from the PDB, contributing to a lack of computational approaches to predict ensemble conformational properties from sequence. Here we combine rational sequence design, large-scale molecular simulations, and deep learning to develop ALBATROSS, a deep learning model for predicting IDR ensemble dimensions from sequence. ALBATROSS enables the instantaneous prediction of ensemble average properties at proteome-wide scale. ALBATROSS is lightweight, easy-to-use, and accessible as both a locally installable software package and a point-and-click style interface in the cloud. We first demonstrate the applicability of our predictors by examining the generalizability of sequence-ensemble relationships in IDRs. Then, we leverage the high-throughput nature of ALBATROSS to characterize emergent biophysical behavior of IDRs within and between proteomes.
Prevalence and Characterization of Sleep Quality and Insomnia in Security Guards Working on the Day and Night Shift in Delhi-NCR
Authors: Singhania Manisha , Sheereen Fauzia J. , Ali Taimul , Reza M Kashif , Khan Abdur R. , Alghadir Ahmad H. , Iqbal Amir , Ahmad Fuzail , Beg Rashid A. , Shaphe Mohammad A.
Published: June 2023

Background
In today’s modern world, shift working has become an important part of society and industrial work; prolonged wakefulness is a widespread phenomenon due to which the sleep patterns of individuals are getting disturbed, and many sleep disorders are arising.
Purpose
This study compared the sleep quality and insomnia in the security guards working the day and night shifts.
Methods
The study comprised 100 security guards from Delhi and the NCR region. Self-administered questionnaires, i.e., PSQI and AIS, were used to assess sleep quality and insomnia. Fifty questionnaires were filled out by the day shift security guards, and the night shift security guards filled out 50. Data were analyzed, and a comparison was made using arithmetic mean and standard deviation.
Results
The result showed a significant difference in sleep quality and insomnia in day shift versus night shift working security guards. The average mean value of sleep quality scoring on the day shift was 6.2 ± 2.38; on the night shift, it was 8.62 ± 6.36. The average mean value of the score of insomnia was 4.44 ± 2.22 in day shift security guards and 6.28 ± 3.18 in night shift security guards.
Conclusion
The study concluded that the night shift working security guards had poorer sleep quality, and insomnia was also more prevalent in them than in day shift working security guards.
National strategies for knowledge translation in health policymaking: a scoping review
Authors: Babarczy Balázs , Scarlett Julia , Sharma Tarang , Gaal Peter , Szécsényi-Nagy Balázs , Kuchenmüller Tanja
Published: June 2023

Background and objectives. Without strategic actions in its support, the translation of scientific research evidence into health policy is often absent or delayed. This review systematically maps and assesses national-level strategic documents in the field of knowledge translation (KT) for health policy, and develops a practical template that can support Evidence-informed Policy Network (EVIPNet) Europe countries in producing national strategies for evidence-informed policymaking. Methods. Websites of organisations with strategic responsibilities in KT were electronically searched, based on pre-defined criteria, in July-August 2017, and a search update was carried out in April-June 2021. We included national strategies or elements of national strategies that dealt with KT activities, as well as similar strategies of individual institutions with a national policy focus. Two reviewers screened the strategies for inclusion. Data were analyzed using qualitative content analysis. Results. Sixty-five unique documents were identified, of which 17 were eligible and analysed for their structure and content. Of the 17, one document was a national KT action plan and six documents were institution-level KT strategies. The remaining 10 strategies, which have also been considered, included two national health strategies, five national health research strategies and three national KT strategies (not specific to health). Thirteen structural elements and seven major themes of health policy KT strategies were identified from the studied documents. Conclusion. KT in health policy, as emerged from the national strategies that our mapping identified, is based on the production and accessibility of policy-relevant research, its packaging for policy-making, and the activities related to knowledge exchange. KT strategies may play different roles in the complex and context-specific process of policy making. Our findings show that the main ideas of health-specific EIP literature appear in these strategies, but their effectiveness depends on the way stakeholders use them. Specific knowledge-brokering institutions and organisational capacity, advocacy about the use of evidence, and close collaboration and co-decision making with key stakeholders are essential in furthering the policy uptake of research results.
Mainstream technologies in facilities for people with intellectual disabilities. A mixed-methods study using the nonadoption, abandonment, scale-up, spread, and sustainability (NASSS) framework
Authors: Menschik Christian , Kunze Christophe , Renner Gregor , Etges Theresa
Published: June 2023

People with intellectual disabilities in residential or outpatient facilities for people with disabilities run the risk of being digitally excluded by not having opportunities for taking advantage of the digitalizations’ possibilities. We therefore aim to investigate how disability caregivers and managers describe barriers and facilitating factors to implement and adopt mainstream technology for people with intellectual disabilities in residential or outpatient facilities and how competencies and capabilities of the caregivers are assessed in the procedure. For this reason, we conducted a mixed-methods-study applying the nonadoption, abandonment, scale-up, spread, and sustainability (NASSS) framework. As a result, we identified barriers and facilitators across NASSS domains. 1. Condition: People with intellectual disabilities are a diverse group of people, where the individual condition of the person and e.g. their communication skills were seen as a perquisite for implementing mainstream technologies. 2. Technology: The extent to what mainstream technology fits the individual needs and demands contributed to the implementation process. 3. Value proposition: Communication was seen as a life area where mainstream technology can add value. Adopters: The caregivers needed competencies and capabilities to accompany their caretakers’ technology use. Organization: Missing legal regulations and lack of personnel resources were described as barriers. Wider context: Funding opportunities were seen as unclear in disability services, as mainstream technologies could not be financed as participation benefits. 7. Embedding and adaptation over time: The COVID-19 pandemic has forced facilities to digitalize to some extent, but were still in need of standardized procedures to promote digital participation of their residents.
Monitoring response to neoadjuvant therapy for breast cancer in all treatment phases using an ultrasound deep learning model
Authors: Zhang Jingwen , Deng Jingwen , Huang Jin , Mei Liye , Liao Ni , Yao Feng , Lei Cheng , Sun Shengrong , Zhang Yimin
Published: June 2023

Purpose: The present study investigated whether deep learning models (DLMs) could replace traditional ultrasound measurement models for predicting pathological responses to neoadjuvant chemotherapy (NAC) for breast cancer.
Methods: Data from 57 patients (443 ultrasound images) who underwent NAC followed by surgery were analyzed. A DLM was developed for accurate breast tumor ultrasound image segmentation. The predictive abilities of the DLM, manual segmentation model (MSM), and two traditional measurement models (longest axis model [LAM] and dual-axis model [DAM]) for pathological complete response (pCR) were compared using tumor size ratios and receiver operating characteristic curves.
Results: The average intersection over the union value of the DLM was 0.8087. MSM showed the best performance with an area under the curve (AUC) of 0.840; DLM performance was slightly weaker with an AUC of 0.756. The AUCs of the two traditional models were 0.778 for LAM and 0.796 for DAM. There was no significant difference in AUC values of the predictive ability of the four models. Moreover, no significant difference in AUC values of ultrasound prediction was noted between each NAC cycle (p<0.05).
Conclusion: Patients in the pCR group had a significantly better response than those in the non-pCR group, and ultrasonography was predictive of pCR in the early stages of NAC. DLMs can replace traditional measurements for predicting pCR.
Uplift modeling to predict individual treatment effects of renal replacement therapy in sepsis-associated acute kidney injury patients
Authors: Li Guanggang , Li Bo , Song Bin , Liu Dandan , Sun Yue , Ju Hongyan , Xu Xiuping , Mao Jingkun , Zhou Feihu
Published: June 2023

Background: Renal replacement therapy (RRT) is a crucial treatment for sepsis-associated acute kidney injury (S-AKI), but it is uncertain which S-AKI patients should receive immediate RRT. Identifying the characteristics of patients who may benefit the most from RRT is an important task.
Methods: This retrospective study utilized a public database and enrolled S-AKI patients, who were divided into RRT and non-RRT groups. Uplift modeling was used to estimate the individual treatment effect (ITE) of RRT. The validity of different models was compared using a qini curve. After labeling the patients in the validation cohort, we characterized the patients who would benefit the most from RRT and created a nomograph.
Result: A total of 8,878 patients were assessed, among whom 687 received RRT, and 8,191 did not receive RRT. The RRT group had a higher severity of illness than the non-group, with a Sequential Organ Failure Assessment (SOFA) score of 9 (IQR 6,12) vs. 5 (IQR 3,7). The 28-day mortality rate was higher in the RRT group than the non-RRT group (34.35% vs. 14.67%, p < 0.0001). Propensity score matching (PSM) was used to balance baseline characteristics, 687 RRT patients and an equal number of non-RRT patients were enrolled for further research. After PSM, there was no significant difference in 28-day mortality between the RRT and non-RRT groups (34.35% vs. 36.83%, P = 0.338). Using uplift modeling, we found that urine output, fluid input, SpO2, BUN, and platelet were the top 5 factors that had the most influence on RRT effect. The area under the uplift curve (AUUC) of the class transformation model was 0.064, the AUUC of SOFA was 0.031, and the AUUC of Kdigo-stage was 0.048. The class transformation model was more efficient in predicting individual treatment effect. A logical regression model was developed, and a nomogram was drawn to predict whether an S-AKI patient can benefit from RRT. Nine factors were taken into account (ventilation, urine output, fluid input, temperature, creatinine, chlorine, pH, white blood cell count, and first care unit).
Conclusion: Uplift modeling can better predict the ITE of RRT on S-AKI patients than conventional score systems such as Kdigo and SOFA. We also found that some inflammation indicators such as temperature and white blood cell count may influence the benefit of RRT on S-AKI patients.
Welding of Dissimilar Polymers
Authors: Marcus Miranda , Nitsch Matt , Cronley Lance , Gottfried Maggie , Ellis Jeff
Published: June 2023

Welding of dissimilar polymers is becoming more common. While joining of dissimilar polymers is traditionally accomplished via the use of adhesives or mechanical methods such as fasteners, snap fits, and staking – these approaches cannot always be effectively applied. For these applications, where adhesives and mechanical bonding can’t be used, it may be possible to directly weld or bond polymers that are miscible but have different material properties via welding techniques. In this work, infrared welding was used to join acrylonitrile butadiene styrene (ABS) to polyphenylene oxide (PPO), ABS to polyvinyl chloride (PVC), and polystyrene (PS) to polycarbonate (PC) as an initial investigation into a new approach to bonding dissimilar polymers. Through the use of targeted heating to match the polymer viscosities to each other, the weld strength was improved by up to three times and, when optimized, the strength of the dissimilar bond as equivalent to that of the similar material weld.
Multi-Resolution Continuous Normalizing Flows
Authors: Voleti Vikram , Finlay Chris , Oberman Adam , Pal Christopher
Published: June 2023

Recent work has shown that Neural Ordinary Differential Equations (ODEs) can serve as generative models of images using the perspective of Continuous Normalizing Flows (CNFs). Such models offer exact likelihood calculation, and invertible generation/density estimation. In this work we introduce a Multi-Resolution variant of such models (MRCNF), by characterizing the conditional distribution over the additional information required to generate a fine image that is consistent with the coarse image. We introduce a transformation between resolutions that allows for no change in the log likelihood. We show that this approach yields comparable likelihood values for various image datasets, with improved performance at higher resolutions, with fewer parameters, using only one GPU. Further, we examine the out-of-distribution properties of MRCNFs, and find that they are similar to those of other likelihood-based generative models.
Water-vapour permeability of inorganic construction materials
Authors: Hall Christopher , Lo Gloria J , Hamilton Andrea
Published: June 2023

Water-vapour permeability (WVP) data on brick, stone, plaster and cement-based materials from some some seventy publications are reviewed and assessed. Almost all sources use standard cup-test methods or close variants. Comparisons of WVP values from different sources on similar materials confirm that reproducibility between different laboratories is poor. Some deficiencies of cup-test methods are discussed, including uncertainties arising from the use of saturated-salt humidistats and desiccants. There is some evidence that the water-vapour resistance factor decreases with increasing mean relative humidity across the test specimen; and weak evidence that the resistance factor increases with volume-fraction porosity. The contribution of liquid film flow to the measured permeability is discussed. It is concluded that (1) available data are inadequate to establish the fundamental physics of WVP; (2) vapouronly permeability data for engineering purposes should be obtained in dry-cup tests at low humidity; and (3) research studies should aim to integrate the WVP into the framework of unsaturated flow theory.