bluuebunny/crossref_metadata_2025 huggingface dataset:
Distinctive morphological variation of saccular otoliths in relation to hermaphroditism type in Sarpa salpa and Serranus scriba (Teleostei: Perciformes) from the Mediterranean Sea in Bizerte, Tunisia
Authors: Bakkari Wided , Mejri Marwa , Bouriga Nawzet , Mili Sami , Chalh Abdellah , Shahin Adel AB , Quignard Jean-Pierre , Trabelsi Monia , Ben Faleh Abderraouf
Published: November 2024

This study aimed to describe and compare the morphological characteristics of saccular otoliths (sagittae) in the protandrous hermaphrodite Sarpa salpa and the synchronous hermaphrodite Serranus scriba collected from the Bizerte site located in northwestern Tunisia, and to examine the effect of hermaphroditism type on the otolith shape and size at the inter- and intraspecific levels, using elliptical Fourier analysis. At the interspecific level, a significant bilateral asymmetry in shape was observed between the left and right otoliths. At the intraspecific level, a significant bilateral asymmetry in shape was detected between the left and right otoliths only in S. scriba. Discriminant function analysis (DFA) produced two separate main groups corresponding to the two species, and intrasexually differentiated between left and right otoliths in S. salpa. In addition, a significant bilateral asymmetry was found in Lo, Wo, Ao, and Po in S. salpa and in Po only in synchronous S. scriba. Thus, protandrous hermaphroditism did not affect otolith shape in S. salpa, but showed an apparent bilateral asymmetry in otolith size. However, synchronous hermaphroditism exhibited a significant bilateral asymmetry in otolith shape and Po only in S. scriba. The causes of this significant inter- and intraspecific bilateral asymmetry observed in otolith shape and size were discussed.
First record of the species Encyonema bonapartei Heudre, C.E.Wetzel & Ector (Cymbellales, Bacillariophyceae) in Serbia
Authors: Vasiljević Božica , Jakovljević Olga , Krizmanić Jelena , Heudre David , Zorić Katarina , Tubić Bojana , Paunović Momir
Published: November 2024

Encyonema bonapartei Heudre, C.E.Wetzel & Ector is a diatom species originally documented in 2016, following its discovery in three canals in the eastern region of France. In 2021, an extensive hydrobiological survey in a mountainous part of southwestern Serbia led to the first finding of this taxon outside of France, i.e. in the Uvac Special Nature Reserve – in Lake Zlatar (Zlatarsko jezero) and in the Marić River (Marića reka). Detailed light microscopy and scanning electron microscopy observations of a large population recorded in Lake Zlatar confirmed the unique morphological characteristics of E. bonapartei, which is also the first record for the diatom flora of Serbia. The present work provides new information on the distribution and ecological preferences of E. bonapartei, taking into account physical and chemical characteristics of its habitats in Serbia.
What does external morphometry tell us about stock discrimination of Sardina pilchardus stocks from Türkiye?
Authors: Ozpicak Melek , Saygin Semra
Published: November 2024

The analysis of shape is a fundamental part of much biological research. Morphometrics, which incorporates concepts from biology, geometry, and statistics, is the study of the geometrical form of organisms. In addition, morphometric characteristics can be used to differentiate ‘phenotypic stocks’ as groups with similar growth, mortality, and reproductive rates. In this study, 25 morphometric characters were used to discriminate European pilchard (Sardina pilchardus) stocks from Türkiye. Intraspecific variation of the European pilchard was investigated based on morphometric characters. Samples were collected from the Aegean Sea (AS; N = 54), the Sea of Marmara (MS; N = 50) and the Mediterranean Sea (MEDS; N = 50) during the 2019 fishing season. Principal Component Analysis (PCA) and Canonical Discriminant Analysis (CDA) were used for stock discrimination of the European pilchard. Univariate statistics (ANOVA) showed that 24 of the 25 measurements differed significantly between samples to a varying degree (p < 0.001). According to CDA, an overall classification success rate of 87.7% was achieved using 12 morphometric parameters. All samples were clearly separated from each other in the discriminant space, suggesting that there was no strong intermingling between populations. In addition, we would like to conclude that the morphological difference is not at the genetic level, and would like to emphasize the need for additional stock discrimination methods.
The Influence of Women’s Leadership on Organizational Alignment with Sustainable Development Goals: A Discriminant Analysis Approach
Authors: Kapse Manohar , Radović-Marković Mirjana , Sharma Vinod , Mahajan Yogesh , Hiremath Rahul B
Published: November 2024

Although it seems that the roles of leaders in sustainable development are extremely important, it is not entirely clear whether the obstacles for women leaders in this context have really changed and to what extent there is still gender discrimination in this domain. In line with this, the study investigates the relationship between the gender of the leaders and the alignment of organizations with the 17 Sustainable Development Goals (SDGs) set by the United Nations. With the growing emphasis on sustainability in business practices, understanding how leadership, particularly CEO gender, influences corporate sustainability initiatives is crucial. The research adopts a quantitative approach to analyze data from organizations led by both male and female CEOs across various industries. By considering the 17 SDGs as independent variables, the study aims to discern whether organizations led by female CEOs exhibit a stronger commitment to specific sustainability goals compared to those led by male CEOs. The analysis seeks to uncover patterns in goal prioritization and explore whether gendered leadership affects sustainability outcomes. The findings are expected to provide insights into how leadership characteristics impact an organization’s sustainability strategies and could suggest future policies and practices aimed at enhancing gender diversity in leadership roles.
MICROCREDIT: A MEANS OF FINANCIAL STABILITY OR A TOOL FOR EXPLOITATION?
Authors: S Shaniba , B Gopika , N Sivakumar , S Nehru
Published: November 2024

Microcredit has received a lot of attention lately since it is hailed as a revolutionary financial instrument for reducing poverty and promoting economic empowerment. This piece explores the dual nature of microcredit, examining how it may be used as a tool for potential exploitation as well as a means of achieving financial security. This research highlights the critical role that microcredit has had in giving marginalised populations access to capital by drawing on an extensive analysis of empirical evidence. It looks at how microcredit initiatives have boosted community development, entrepreneurship, and income production, thereby empowering people, especially women. These encouraging results highlight microcredit's capacity to promote economic resilience and financial stability.  On the other hand, the research also reveals the negative aspects of microcredit. The research indicates that low-income individuals with inadequate financial and educational backgrounds are using microcredit to cover everyday household needs because there are insufficient regulating authorities in place. With no other feasible choice, these people are turning to microcredit, where they frequently run into predatory practises such excessive interest rates and forceful loan practises. The positive effects of microcredit are overshadowed by these practises, which give rise to serious ethical and social concerns.
Eh, mi a név?
Authors: Tasi Réka
Published: November 2024

On 28 November 2023, the Miskolc Regional Committee of the Hungarian Academy of Sciences organised a conference on the above-mentioned topic, with 13 speakers in attendance. In my opening remarks, I emphasised the interdisciplinary nature of the conference, citing an example of the relationship between proper names and literary texts: I referred to the poem written by Miklós Zrínyi in 1659, which is known in the literature as „Elégia”. I then highlighted one of the scientific theses of the conference, namely that names in literary texts can facilitate a deeper understanding of the functioning and nature of literary fiction.
Névhasználati stratégiák a klasszikus századforduló epigrammagyűjteményeiben
Authors: Fekete Norbert
Published: November 2024

At the turn of the eighteenth and nineteenth centuries, the acceptance of criticism as a genre was controversial in Hungarian classical literature. On the one hand, contemporary interpreters debated who had the authority to write criticisms; on the other hand, the critical and pedagogical principles of the reviewer’s opinion were often questioned; and thirdly, the genres in which literary works could be criticised were also under discussion. In many instances, these questions were addressed through the conscious use of author’s names, as critics expressed their opinions anonymously, under pseudonyms, or in reviews under their own names. At that time, epigrams were considered a more acceptable form of critical expression than printed reviews. This paper is based on the collections of epigrams in Ferenc Kazinczy’s Tövisek és virágok [‘Thorns and Flowers’] and those published by the members of the Aurora Circle (József Bajza, Károly Kisfaludy, György Stettner, Ferenc Toldy, and Mihály Vörösmarty) in the journal Kritikai Lapok [‘Critical Papers’] under the titles Kritikai pálya-ágak [‘Critical Career Branches’] and Pályalombok [‘Career Leaves’]. It analyses the aesthetic, critical and rhetorical roles played by the author’s names and other proper names in the poems. By examining the author’s names in the collections of epigrams and the proper names created in the poems through various rhetorical devices, a new perspective can be taken on the aesthetic, critical, canonising and career-building aspirations behind the volumes. Furthermore, the texts examined reveal the specificities of the naming practices of the two generations of writers.
Impact of the genomic signature of 70 genes for breast cancer in the public system and in supplementary health care in a country of medium socioeconomic development
Authors: Mansani Fabio Postiglione , Soares Leonardo Ribeiro , Freitas-Junior Ruffo
Published: November 2024

Objective: This study aimed to evaluate the financial viability of using the MammaPrint™ (MP) genetic signature in a public and private system in a country with a medium socioeconomic development index. Methodology: A pharmacoeconomic trial with a cost-benefit analysis evaluating the reduction in costs of chemotherapy, support drugs, and materials used during chemotherapy infusion in high-risk hormone receptor-positive (HR+) breast cancer patients submitted to analysis using the MP™ genetic signature. Results: The value of using MP in the Unified Health System (SUS) would bring an additional cost of US$ 1334.56 per patient in the over-50-year age group. In private medicine, the use of MP in the same population would result in cost savings ranging from US$ 2422.53 to US$ 9989.95 per patient. Conclusion: The use of MP in RH+ breast cancer patients with high clinical risk and low genomic risk in Brazil leads to significant savings in resources when applied to supplementary healthcare. In the SUS, reducing the costs of MP for large-scale use could make its application viable. These values need to be re-evaluated in each institution, using the methodology applied in the trial, adjusting according to costs, to obtain a result that reflects its reality.
Immunohistochemical and molecular aspects of phyllodes tumors of the breast and the repercussions on diagnosis and treatment: a scope review
Authors: Silveira Neto Luiz de Paula , Silveira Júnior Luiz de Paula , Paula Maria Luiza Bessa de , Piva Luiza Cesca
Published: November 2024

Objective: The objectives were to highlight the importance of immunohistochemical and molecular markers in the diagnosis, treatment, and prognosis of phyllodes tumors. A total of 424 publications were identified from the database search, and in the end, 39 studies were included in the synthesis. Methodology: The methodology of this study is a scoping bibliographic review, using the writers “phyllodes tumor” AND “immunohistochemistry” in the databases PubMed, SciELO, LILACS, Cochrane Library, NIH, Clinical Trials, NICE, and BVSMS. A total of 424 publications were identified from the database search, and in the end, 39 studies were included in the synthesis. Results: The results demonstrate that numerous immunohistochemical markers have been studied in an attempt to improve the accuracy in the diagnosis of benign, borderline, and malignant phyllodes tumors, such as p53, Ki67, CD117, EGFR, p16, VEGF, CD34, β-catenin, E-cadherin, B7H3, EZH2, ZEB1/ILK, c-Kit, BIK, p-BIK, CD44, and cancer stem cell markers. The higher expression of E-cadherin, β-catenin, and CD34 corroborates the diagnosis of benign phyllodes tumor, while borderline phyllodes tumor can express B7H3, CD34, c-Kit, and Ki67. An association of histological characteristics, high mitotic index, and expression of Ki67 and p53 in malignant phyllodes tumors was verified. High stromal expression of EZH2 in malignant phyllodes tumors has been reported in cases with lower disease-free survival and overall survival, and BIK and p-BIK proteins have very low expressions in these tumors. Conclusion: Extensive surgical removal is consolidated as the gold standard of treatment for phyllodes tumors. However, it is important to highlight that immunohistochemistry is a potential diagnostic tool in the evaluation of phyllodes tumors, along with histopathological characteristics, and in the near future, it may have repercussions and impact on the treatment and prognosis of these tumors.
Retrospective analysis of the epidemiological profile of patients submitted to breast reconstruction at a public hospital in the Northeast
Authors: Ferreira Filho Darley de Lima , Ferreiran Nancy Cristina Ferraz de Lucena , Ferreira Thais de Lucena
Published: November 2024

Objective: Breast reconstruction is a right assured by the public health system to patients submitted to mastectomy. However, there are factors that delay the performance of this procedure. To understand the epidemiological profile of women with breast cancer who underwent breast reconstruction in a reference hospital in the state of Pernambuco. Methodology: This is an observational, retrospective research with an analytical character and descriptive approach. The data were collected through a questionnaire sociodemographic and clinical-surgical history of patients with breast carcinoma and then analyzed by the SPSS software, version 18, with the percentages of the categories evaluated by the chi- -square test, considering the significance level of 5%. The comparison of analyses was significant (p <0.005), showing that the profile described is the most frequent in the group of patients evaluated. This search was submitted and approved by the Ethics and Research Committee on Human Beings of Fundação Amaury de Medeiros, CAAE: 42457420.1.0000.5193. Results: A non-probabilistic sample of 400 records was obtained in 10 years at a tertiary hospital in Recife (PE), most of them with mean ages between 46 and 59 years (45.3%), brown (61.1%), married (79.1%), with education until high school (60.7%), household professionals (45%), non-smokers (84.9%), who do not consume alcohol (94.9%) and had immediate; reconstruction after mastectomy (70.3%). A lot of patients used the region flaps (45%) and the second most used type of reconstruction was myocutaneous flaps (23%). The subtype molecular most frequently was luminal (60%). Conclusion: The findings support that patients with high educational levels are likely to undergo immediate breast reconstruction, pointing out that the socioeconomic level significantly influences the rates of breast reconstruction after mastectomy or setorectomy.
A new navigation aid tool: Instagram as a facilitator of breast health education
Authors: Ferreira Filho Darley de Lima , Ferreira Nancy Cristina Ferraz de Lucena , Ferraz Juliana Porto , Perazzo Maria Augusta Monteiro
Published: November 2024

Objective: The purpose of navigation is, therefore, to appropriately direct patients who will need continued care within the health system. In the context of breast cancer patients, this appears to be promising and necessary so that they do not lose follow-up but also maintain continuity in the provision of medical care postponed due to system failures. The key point of navigation is to look for which mechanisms contribute to delays in care, identifying and addressing barriers in the path of care and treatment. Methodology: This was an observational, prospective, experimental study with the objective of evaluating Instagram as a facilitating tool for the navigation of patients who were monitored at the mastology outpatient clinic of the Santa Casa de Misericórdia do Recife hospital, Hospital Barão de Lucena, and the Pernambuco Military Police Hospital (HPMPE). Finally, it is worth mentioning that the project was submitted to the Brasil platform under the number (CAAE 74006323.0.0000.5205). Results: A total of 105 screening patients were identified as potentially eligible during medical care at the mastology outpatient clinic at the (HBL), the HPMPE, and the Santa Casa de Misericórdia do. Among these, nine patients captured at the Santa Casa de Misericórdia were excluded since, even during the data collection period, that hospital was no longer part of this research due to loss of ties with the researchers. In the HPMPE, a total of 21 patients were eligible, 6 of whom were excluded because they did not meet the inclusion criteria, considering that it was not possible to contact them to apply for the post-test. In the HBL, a total of 76 patients were eligible, 13 of whom were excluded because they did not meet the inclusion criteria: four patients refused to take the post-test, and nine patients were lost to follow-up, as it was not possible to establish contact. Conclusion: Through this study, we concluded that the Instagram platform is a useful tool for navigating breast cancer patients, which is capable of significantly reducing barriers.
Education evaluation with breast cancer: an ecological study
Authors: Ferreira Filho Darley de Lima , Lucena Ferreira Nancy Cristina Ferraz de , Maciel Renata , Carvalho Bruna Daniela , Pereira Maria Eduarda Candeias Gomes
Published: November 2024

Objective: This study aimed to analyze the association between education level and breast cancer in Brazil among women from 20130 to 2022 and observe the relationship between education level and mortality rate in different regions of Brazil, under the hypothesis that women with lower education levels are diagnosed at more advanced stages, resulting in higher mortality rates. Methodology: This is an ecological study, using a time series design, based on the data collected from the national DATASUS database, including female individuals affected by malignant neoplasm of the breast between 2010 and 2022. Results: Among the risk factors related to a worse prognosis for breast cancer, education level stands out. A higher number of cases can be observed in patients with lower levels of education, which is more evident in the south, southeast, and midwest regions. The low level of education combined with socioeconomic factors leads to a lack of knowledge about the disease and its early detection methods, resulting in restricted access to healthcare services, delays in conducting and receiving tests, and difficulties in transportation to consults and treatment centers. Furthermore, a higher mortality rate was observed in regions such as the south, southeast, and midwest, reinforcing that women with lower education levels have a higher probability of presenting a more advanced stage of cancer at the time of diagnosis, resulting in a worse prognosis. Conclusion: The education level of patients proved to be an important factor related to worse outcomes in women with breast cancer in most regions of Brazil, associated with a lack of education and hindered access to healthcare services.
Analysis of the breast cancer mortality rate in recent years in different regions of Brazil
Authors: Rocha Marina Elias , Reis Amanda de Borba , Santos Ana Flávia Silva , Crozara Giovanna Lyssa de Sousa , Silva Gustavo Souza Miranda da
Published: November 2024

Objective: This study aimed to analyze the breast cancer mortality rate in recent years in different regions of Brazil. Methodology: A literary, descriptive, and qualitative study was carried out, using the data collected from the annual reports of the National Cancer Institute and the Ministry of Health, in the years 2019 and 2024, about breast cancer mortality in Brazil. Results: When carrying out the studies, it is noted that breast cancer is the first cause of death in women in Brazil, in addition to being something of concern for Brazilian health, and is also marked by great challenges for those who go through this situation. It is observed that lethality is higher at older ages, but, between 40 and 49 years of age, this rate decreases. First of all, it is extremely important to know the risk factors: age over 50 years, nulliparity, late pregnancy, obesity, and sedentary lifestyle, among others. Therefore, screening is necessary so that if the disease appears, diagnosis and treatment can occur as quickly as possible, thus avoiding death. Conclusion: Considering that breast cancer has a directly proportional relationship to age over 50 years, sedentary lifestyle, and nulliparity, it is concluded that understanding the contribution of risk factors to breast cancer allows health professionals to develop health strategies in order to track and prevent more cases of breast cancer deaths in Brazil.
Effects of chemotherapy on peripheral neuropathy of women breast cancer survivors: an integrative review
Authors: Rodarte Tatiane Nunes da Silva , Marques Vitor Alves , Noleto Flavia Batista Gomes , Oliveira Ellen Gomes de , Silva Anderson Garcia , Alves Rafael Ribeiro , Vieira Carlos Alexandre
Published: November 2024

Objective: This study aimed to systematize the knowledge produced in articles on chemotherapy-induced peripheral neuropathy (CIPN) and its effects on the quality of life of women breast cancer survivors. Methodology: The SCOPUS, PubMed, and SciELO databases were consulted for the selection of articles. Experimental and non-experimental studies published from 2011 to 2023 were selected. The descriptors used were peripheral neuropathy, chemotherapy, breast cancer, quality of life, and pain management. Results: A total of 11 articles were analyzed, of which three were published in English and eight in Portuguese. The findings point to the importance of diagnosing and evaluating CIPN, using specific diagnostics and evaluation methods, as well as sensitivity testing. Risk factors for developing CIPN include older age, history of neurological disease, genetic predisposition, type and dose of chemotherapy, and duration of treatment. The prevention and management of CIPN involve pharmacological strategies, such as anticonvulsants, and non-pharmacological strategies, including physical and occupational therapy, as well as complementary strategies such as acupuncture. CIPN has a profound impact on quality of life, affecting physical, psychological, and social aspects. The pain and loss of sensation limit mobility and independence, while the psychological impact includes anxiety and depression. Socially, isolation and difficulties at work contribute to a decline in quality of life. Conclusion: An interdisciplinary approach should be adopted that incorporates different therapeutic strategies to improve the quality of life and well-being of these patients.
Effects of low volume resistance training on blood pressure changes, glycemic levels, fatigue scores, bone mineral density, and muscle strength: a case study at a university hospital
Authors: Alves Rafael Ribeiro , Rosa Victor Domingos Lisita , Silva Anderson Garcia , Oliveira Ellen Gomes de , Santos Jessika Teodoro , Damasio Nathan Muci Aguiar , Freitas-Junior Ruffo , Vieira Carlos Alexandre
Published: November 2024

Objective: This study aimed to evaluate the effects of one resistance training (RT) session per week on indicators of blood pressure, glycemic levels, fatigue scores, bone mineral density, and muscle strength. Methodology: A case study was conducted with an elderly patient (78 years old; body mass: 82.8 kg; height (m): 1.54; body mass index: 34.7 kg/m²), breast cancer survivor, with mastectomy, undergoing hormone therapy, diagnosed with type II diabetes, hypertension, and grade I obesity. The RT consisted of one session per week for 8 weeks. The sessions consisted of only four exercises: bench press, lat pulldown, leg press, and crunch exercises, with progressive intensity increase throughout the sessions, which lasted an average of 30 min. Before and after the period of training, resting blood pressure, fasting blood glucose, fatigue scores, bone mineral density, and muscle strength were evaluated (CEP: 50717115.4.0000.5083). Results: Systolic blood pressure did not change significantly between pré and post moment (152 and 147 mmHg, respectively) as did diastolic blood pressure (77 and 76 mmHg, respectively), as well as total bone mineral density (pre=2.3 g/cm² and post=2.4 g/cm²). However, fasting blood glucose changed the classification values (pre=129 mg/dL and post=97 mg/dL). Fatigue levels classified at the pre- -moment as moderate in the behavioral (2.2), affective (2.8), and sensory (0.4) domains reduced to the absence of fatigue after the intervention, although without classification change in the cognitive domain (pre=3.5 and post=1.6, respectively). Additionally, performance in the muscle strength test increased by 33% between pre-moment (90 kg) and post-moment (120 kg). Conclusion: A low volume of RT was able to improve glycemic levels, fatigue scores, and muscle strength performance in an elderly breast cancer survivor with diabetes, hypertension, and obesity.
Role of the nurse in the mental health of patients under breast cancer treatment
Authors: Rocha Marina Elias , Machado Geffson Damaceno , Oliveira Éllyda Vanessa Leonel , Santos Jaziane Gonçalves
Published: November 2024

Objective: This study aimed to highlight the importance of nurses as assistants in the mental health care of patients undergoing breast cancer treatment. Methodology: An integrative literature review was carried out from 2022 to 2023, using the PubMed, Medline, and Scielo databases. Results: Breast cancer is seen as a neoplasm that most affects women in the world; therefore, it is a disease surrounded by stigma and suffering that significantly affect the mental health of the patient who is diagnosed and it is extremely important to qualify the professional who will provide the necessary care according to the needs of each case. The role of the nurse is necessary both in prevention and, crucially, after diagnosis, in rehabilitation, providing holistic assistance, taking into account the importance of the work of the multidisciplinary team, assisting in the care plan and decision-making regarding the needs of each patient, and promoting good maintenance of physical and mental comfort. It is up to the nurse to provide humanized and effective assistance that reduces the suffering caused by this illness. In view of this, we can mention the qualification regarding the humanized and cautious approach to the treatment, which, as it is an aggressive disease, becomes long, exhausting, and causes a lot of suffering. Conclusion: Therefore, to identify the importance of professional nurses in relation to the mental health of patients fighting breast cancer, it was noted such importance in relation to humanized and personalized care, with vast knowledge being evident and necessary to adequate planning that will be effective both in prevention and after diagnosis in support for these patients who will continue to be assisted both with drug therapies and in a biopsychosocial way, having a long quality of life in the professional, personal, and social spheres.
Sequential single-agent chemotherapy as neoadjuvant treatment in early stage HER2 positive breast cancer during pregnancy: case report
Authors: Apolinário Thiago Lourenço , Jesus Cinthya Roberta Santos de
Published: November 2024

Objective: This is a case report about a successful treatment using sequential chemotherapy in pregnant patients with early HER2-positive breast cancer. Results: Clinical case: A 38-year-old woman was referred to our hospital on May 26, 2022, diagnosed with an early (T1N0M0, stage IA) invasive carcinoma of no special type hormonal receptor-positive HER2- positive tumor on the left breast and a 12-week pregnancy. The patient started the neoadjuvant treatment at 13 weeks and 5 days of gestational age on May 31 with four cycles of 3-weekly Doxorubicin, finishing on August 9. The treatment with Cyclophosphamide was delayed by 1 week because of transport problems, starting on August 30 and finishing on October 11. We employed a dose-dense regimen to allow time for recovery before childbirth, scheduled for November 4. The labor was a cesarean section without complications. We restarted the treatment with weekly paclitaxel and trastuzumab on November 15, 2022, after 5 weeks from the last chemotherapy. The patient underwent breast-conserving surgery and sentinel lymph node biopsy without complications, resulting in a complete pathologic response in the pathology report. She received adjuvant treatment with radiotherapy and started tamoxifen. She completed the treatment with trastuzumab. Conclusion: As demonstrated in the CALGB 9741 study, single sequential chemotherapy is equally effective as a concurrent protocol, being an option for patients in the early stages of the second trimester, reducing fetal exposure to chemotherapeutic agents, and enabling concomitant use of trastuzumab with taxane.
Male breast cancer
Authors: Rocha Marina Elias , Santos Jaziane Gonçalves , Oliveira Éllyda Vanessa Leonel , Machado Geffson Damaceno
Published: November 2024

Objective: This study aimed to describe breast cancer in the male population in the literature. Methodology: An integrative literature review was carried out from 2014 to 2019, using the PubMed, Medline, and Scielo databases. Results: Malignant breast neoplasia is much more common in women and rare in men, accounting for around 1% of diagnoses, making it an uncommon cancer and being more common in patients aged 60–70 years. Lobular and the most common is ductal carcinoma, and the diagnosis is made through clinical ultrasound, mammography, and pathological studies. The assessment of genetic factors in first-degree relatives is very important. They are present in 20% of cases. We have several risk factors: hormonal, such as prostate cancer treatment, and the use of transsexuals. Obesity is one of the most frequent causes, and in cases of environmental issues, for both men and women, the treatment is similar. As initial surgery for the removal of breast tissue, nipple, and axillary emptying, others such as hormone therapy, chemotherapy, and radiotherapy have not been studied much, but due to the positivity in the receptors, it has been chosen in adjuvant treatment and followed the female guidelines. Of 80, 90% of diagnosed patients have positive estrogen and progesterone receptors. Conclusion: Breast cancer is very similar between men and women. Differences in prognostic characteristics may necessitate a different approach compared with female breast cancer.
Intraoperative physiotherapeutic approach in oncoplastic surgery: case report
Authors: Lemos Nayara Alves de Freitas , Paulinelli Régis Resende
Published: November 2024

Introduction: Fat grafting is a very useful technique in partial and total breast reconstructions. In this technique, where adipose tissue is liposuctioned and purified, it is injected into the breast tissue or thoracic wall to correct deformities or due to its regenerative effect on the skin, improving elasticity and reducing the risk of capsular contracture and rippling. The donor region may experience pain, swelling, and bruising, natural events of inflammation. Normally, mechanical compression is applied, such as a surgical shaper, but the importance of physiotherapeutic action in the recovery process deserves further study. Methodology: Ethical Aspects: The patient signed an informed consent form for the presentation and publication of the Case Report. Case Report: Patient L.M.R.M, female, 68 years old, underwent mastectomy and axillary clearance and immediate reconstruction with an expander on the left side, in January 2022. The anatomopathological study showed classic lobular carcinoma, grade 1, 3.2 cm, 7/24 lymph nodes, and TNM classification pT2pN2M0 IIIb. Luminal B. She finished chemotherapy and, soon after, 15 sessions of radiotherapy. She underwent a second surgical approach in 2023, Liposuction 480 mL lipofilling, exchange for an extra high projection anatomical implant, and on the right breast, augmentation mammoplasty and mastopexy. She uses letrozole and aprazolam. Results: Physiotherapy Approach: Because it is mature skin, concerning the aesthetic and functional appearance of the abdominal region, as the donor region, adhesive elastic bandages were applied intraoperatively with the aim of reducing pain, containing swelling, tissue alignment, favoring skin retraction, absorbing bruises, and preventing fibrosis. The patient received 3 weekly physiotherapy sessions after the removal of the bandages, on the seventh postoperative day. During the sessions, the approach was through manual therapies and kinesiotherapy. Conclusion: We believe that physiotherapy helps the patient resume her daily life activities with functionality and a better quality of life, as happens in aesthetic plastic surgeries.
Pertumbuhan dan Hasil Ratun Beberapa Varietas Sorgum (Sorghum Bicolor (L) Moench) pada Percobaan di Rumah Kaca
Authors: Ghea Amelia Putri  , Akhmad Zubaidi  , Dwi Ratna Anugrahwati
Published: November 2024

Penelitian ini bertujuan untuk mengetahui pertumbuhan dan hasil ratun beberapa varietas sorgum (Sorghum bicolor (L) Moench) pada percobaan di Rumah kaca. Metode penelitian menggunakan metode eksperimental dengan rancangan acak lengkap (RAL) yaitu faktor perlakuan varietas yang dilaksakan di Glasshouse Fakultas Pertanian Universitas Mataram dari bulan juli sampai Oktober 2023. Terdapat 5 perlakuan yakni varietas Bioguma, Gando Keta, Pahat, Super 1, Suri 4 diulang sebanyak 4 kali, sehingga terdapat 20 unit percobaan. Parameter pengamatan yaitu Tinggi tanaman, jumlah daun, diameter batang, bobot berangkasan kering, Panjang malai, bobot malai, jumlah biji, bobot biji, bobot 1000 biji. Data dianalisis menggunakan Analysis Of Variance (ANOVA) uji Beda Nyata Jujur (BNJ) pada taraf nyata 5%. Hasil penelitian menunjukkan terdapat perbedaan signifikan terhadap pertumbuhan dan hasil ratun beberapa varietas yang diuji. Pertumbuhan hasil dan ratun terbaik yakni varietas Pahat dan Suri 4 dapat dilihat dari nilai bobot berangkasan kering berturut-turut yang tinggi sebesar 116,10 g dan 105,47 g, serta memiliki hasil biji yang tinggi sebesar 77,33 g dan 71,50 g.
Pengembangan Media Congklak Matematika Untuk Pembelajaran Matematika Pada Materi KPK dan FPB Kelas V SDN 38 Cakranegara
Authors: Sajida Fibriana , Arjudin Arjudin , Fauzi Asri
Published: November 2024

Pengunaan media dalam pembelajaran berperan penting sebagai penyalur informasi sehingga tujuan pembelajaran dapat tercapai secara maksimal. Penelitian ini bertujuan untuk mengembangkan media congklak matematika untuk pembelajaran matematika pada kelas V materi KPK dan FPB yang valid, praktis dan efektif. Penelitian ini menggunakan metode penelitian Reserch and Development (R&D) dengan menggunakan model pengembangan ADDIE (Analyze, Design, Development, Implementation, Evaluation). Tempat dilakukan penelitian yaitu SDN 38 Cakranegara dengan subjek penelitian siswa kelas V sebanyak 14 siswa. Sedangkan objek penelitian ini yaitu media congklak matematika untuk materi KPK dan FPB. Instrumen penelitian yang digunakan adalah lembar angket validasi ahli media dan materi, angket respon guru, serta tes pemahaman konsep siswa. Teknik analisis data dalam penelitian ini menggunakan skala likert dengan skor penilaian yaitu 1 sampai 4 meliputi analisis data kevalidan, kepraktisan, dan keefektifan. Hasil penelitian ini menunjukkan bahwa media congklak matematika untuk pembelajaran matematika pada materi KPK dan FPB mendapatkan presentase 88% dengan kriteria sangat valid dari ahli media, presentase 90% dengan kriteria sangat valid dari ahli materi, presentase 91% dengan kriteria sangat praktis dari respon guru, dan presentase 92,85% dengan kriteria sangat efektif dari hasil tes pemahaman konsep siswa yang dihitung dengan ketuntasan belajar klasikal. Oleh karena itu, berdasarkan hasil penelitian, dapat disimpulkan bahwa media congklak matematika untuk pembelajaran matematika tentang materi KPK dan FPB sudah layak dari aspek valid, praktis dan efektif untuk digunakan sebagai media pembelajaran di kelas 5 SDN 38 Cakranegara.
Pengembangan Media Scrapbook Berbasis Aplikasi Canva Pada Mata Pelajaran IPAS Materi Ekosistem Kelas V SDN 1 Karang Bayan
Authors: Mardian Risna , Husniati Husniati , Syazali Muhammad
Published: November 2024

Pada proses pembelajaran di dalam kelas, guru masih minim menggunakan media pembelajaran di dalam kelas, sehingga pembelajaran terkesan monoton sehingga dalam hal ini, peneliti menggembangkan media pembelajaran scrapbook berbasis aplikasi canva dengan suatu keterbaruan yaitu adanya suatu kantong ajaib berisi soal dan kunci jawaban. Tujuan penelitian ini yaitu untuk mengetahui kelayakan dan kepraktisan media pembelajaran media scrapbook berbasis aplikasi canva pada mata pelajaran IPAS materi ekosistem di kelas V SDN 1 Karang Bayan. Jenis penelitian yang digunakan yaitu Reaserch and Development (R&D) menggunakan model penelitian sugiyono yaitu 10 tahapan, namun peneliti hanya menggunakan 7 tahapan (potensi masalah, pengumpulan data, desain produk, validasi desain, revisi desain, uji coba produk, dan revisi produk) hasil penilaian dari 2 ahli yaitu ahli media memperoleh nilai 90% menempati kategori sangat layak dan ahli materi memperoleh nilai 92% menempati kategori sangat layak. Hasil respon guru terhadap media scrapbook berbasis aplikasi canva yaitu memperoleh nilai 98% menempati kategori sangat praktis serta nilai respon 8 peserta didik yaitu 97% menempati kategori sangat praktis. Oleh karena itu, media scrapbook berbasis aplikasi canva pada mata pelajaran IPAS materi ekosistem sangat layak dan praktis digunakan di dalam kelas.
Comparison of outcome of Simple Excision vs Limberg Flap of pilonidal sinus in terms of post operative pain, operative time, wound infection and hospital stay.
Authors: Muhammad Aqeel  , Ahmed Siddique Ammar  , Muhammad Shoaib  , Alam Humaira , Wajahat Amir  , Abrar ul Hassan Pirzada
Published: November 2024

Objective: To compare post operative pain, wound infection, intraoperative time and length of hospital stay in both groups of simple excision and Limberg flap. Study Design: Comparative Prospective study. Setting: CMA Teaching and Research Hospital/Azra Naheed Medical and Dental College, Lahore, Pakistan. Period: 1st September 2021 to 1st September 2023. Methods: After approval from the Institutional review board of Azra Naheed Medical & Dental College/CMA Hospital, the sample was 120 patients was raised using non-convenience probability sampling divided into 2 groups. Group A patients underwent simple excision while Group B patients underwent Limberg flap Inclusion criteria include all the patients with age more than 13 years and diagnosed as case of pilonidal sinus. All the data was entered and processed by using SPSS 26. Comparison of two groups was done by apply independent sample t-test. A p-value of ≤ 0.05 was considered significant. Results: The average age of the patients was 45.88 ± 9.78 years with minimum and maximum ages were 15 & 59 year respectively. Mean post operative pain was 2.6 ± 1.9 in group A while 3.9 ± 2.7 in group B (p value = <0.05). Similarly wound infection, duration of surgery and length of hospital stay were also less in group A patients as compared to group B patients. Conclusion: Simple excision of pilonidal sinus is better from Limberg flap in terms of post operative pain, wound infection, duration of surgery and length of hospital stay.
Diagnosis of cystoid macular edema by comparison of pre-operation and post-operation macular thickness calculated by optical coherence tomography (OCT) after cataract extraction surgery with and without pre-operative use of NSAIDS.
Authors: Adil Rouf  , Haider Ali Chaudhry  , Gulnaz  , Sadia Khalid
Published: November 2024

ABSTRACT… Objective: To compare mean macular thickness after cataract extraction surgery with and without pre-operative NSAIDs. Study Design: Randomized Controlled Trial. Setting: Department of Ophthalmology, Madinah Teaching Hospital, Faisalabad. Period: 21-10-2022 to 20-04-2023. Methods: Total 640 patients (320 in each group) were involved in the study. In group-A patients received one drop of NSAID three times a day for one day prior surgery. In group-B, patients not received NSAID. Results: Results showed that there was a total 395 males and 245 females. Mean age of the patients was 48.24±5.54 in group A and 47.05±5.20 in group B. Comparison of macular thickness showed that thickness was 215.69±14.20 in group A and 227.99±06.09 in group B. There was a significant difference in macular thickness of two groups (P <0.001). Conclusion: In conclusion, preoperative usage of NSAIDs revealed statistically significant (p0.001) and clinically relevant benefits in avoiding macular edoema and preserving visual acuity in patients undergoing cataract surgery as compared to the non-NSAIDs group.
Effect of hospital nutrition program on growth of very low birth weight preterm babies.
Authors: Wasif Ijaz  , Ather Razzaq  , Syed Hassan Ahmad  , Sidra Saleem  , Meh Jabeen
Published: November 2024

Objective: To determine the effect of hospital nutrition program on growth of very low birth weight (VLBW) and extremely low birth weight (ELBW) babies. Study Design: Cross-sectional study. Setting: Neonatal Intensive Care Unit (NICU) of Recep Tayyep Erdogan Hospital, Muzaffargarh, Pakistan. Period: February 2024 to July 2024. Methods: Inclusion criteria were preterm newborns weighing below 1500 grams, admitted in NICU and who received total parenteral nutrition (TPN). VLBW was labeled as birth weight between 1000-1499 grams, while ELBW as birth weight <1000 grams. Hospital nutrition program included TPN plus orogastric feed or nasogastric feeding plus micronutrients. Effect of hospital nutrition program was described as effective if the baby at the time of discharge added 17-20 g/kg/day according to ESPHGAN recommendation. Results: In a total of 131 newborns, 69 (52.7%) were boys. The mean gestational age, and birth weight were 29.68±1.87 weeks, and 1024.50±144.23 grams, respectively. The mean net daily weight gain at the time of discharge was 12.77±3.63 grams. The effective hospital nutrition program was noted in 23 (17.6%) babies. Effectiveness of hospital nutrition program was significantly associated with higher birth weight (1094.78±114.41 vs. 1009.54±145.93 grams, p=0.010), very low birth weight versus extremely low birth weight (87.0% vs. 13.0%, p<0.001), head circumference ≥30 cm (87.0% vs. 53.7%, p=0.003), and gestational age > 28 weeks (87.0% vs. 57.4%, p=0.008). Conclusion: The hospital nutrition program had limited effectiveness, with only 17.6% of VLBW and ELBW infants achieving the recommended weight gain by discharge.
Clinical characteristics of COVID-19 patients admitted to the intensive care unit of the largest public-sector hospital in Karachi: A retrospective, observational study.
Authors: Muhammad Tanveer Alam  , Aasma Khan  , Arjan Kumar  , Muhammad Rehan  , Imran Sarwar Shaikh  , Nazia Azam Yousfani
Published: November 2024

Objective: To characterize the clinical features of critically ill COVID-19 patients admitted to COVID-ICU and describe their outcomes. Study Design: Retrospective Observational study. Setting: Dr. Ruth K. M. Pfau Civil Hospital Karachi, Pakistan. Period: May 2020 to September 2021. Methods: The study aimed to investigate the clinical characteristics and outcomes of patients with confirmed or suspected COVID-19 who were admitted to the ICU. Patients in the study period confirmed or suspected COVID-19, admitted to the ICU for more than 24 hours, and committed to full treatment were included this study. Patients with COVID-19 discharged or died within 24 hours of admission were excluded. Results: The most commonly observed symptoms among the patients were shortness of breath (92.5%), fever (91.2%), cough without sputum (39.2%), altered consciousness (11.9%), and muscle aches (8.8%). Acute respiratory distress syndrome (ARDS) was identified as the most prevalent complication among COVID-19 patients, impacting 40.8% of the study population. A significant proportion of COVID-19 patients required mechanical ventilation and cardiac support. Specifically, (41.4%) of the patients required invasive mechanical ventilation, (47.4%) required non-invasive ventilation, and (26.3%) received cardiac support. Laboratory assessment showed that platelet counts varied significantly between survivors and non-survivors, with non-survivors exhibiting lower platelet counts. Gender differences were also observed among COVID-19 patients by age, with males having a higher mean age than females in all age categories, and the difference was statistically significant (p < 0.001) in all age categories except for the 30-44 years age category (p = 0.087). Age-wise recovery and mortality rates were analyzed, and the results showed that among both deceased and recovered patients, the proportion of deceased patients increased with age, while the proportion of recovered patients increased until the age range of 45-59 years for both males and females. The study found that 136 of the patients survived while 275 of the patients succumbed to the disease. Among the survivors, (31.3%) were male, and (36.2%) were female. Conclusion: The study emphasizes the importance of monitoring patients for potential complications and providing them with supportive care. Early detection and management of severe cases of COVID-19 are critical in preventing complications and improving patient outcomes.
KOMUNIKASI TERAPEUTIK SEBAGAI SARANA EFEKTIF BAGI TINDAKAN KEPERAWATAN YANG OPTIMAL
Authors: Mulyadi AS , MA Syaripudin
Published: November 2024

Therapeutic communication is communication carried out by a nurse in a planned, conscious, and directed towards restoring the patient's health. Poorly implemented therapeutic communication will cause patients to be less cooperative in responding to directions and suggestions from nurses on every treatment action given. In order to improve the quality of treatment, which is in accordance with treatment standards, one of the efforts made is by implementing therapeutic communication as an advantage, because without a good communication process there will be no goodness in every activity, especially between nurses and patients. Therapeutic communication is carried out with several steps, including; Pre-Interaction Phase, Orientation Phase, Work Phase and Terminal Phase with the target of optimizing treatment actions.
Komunikasi terapeutik merupakan komunikasi yang dilakukan oleh seorang perawat secara terencana, sadar, dan diarahkan terhadap pemulihan kesehatan pasien. Komunikasi terapeutik yang dilaksanakan kurang baik, akan menyebabkan pasien kurang kooperatif dalam menanggapi arahan dan saran dari perawat pada setiap tindakan pengobatan yang diberikan. Dalam rangka meningkatkan kualitas pengobatan, yang sesuai dengan standar pengobatan, maka usaha yang dilakukan salah satunya dengan menerapkan komunikasi terapeutik sebagai keunggulan, karena tanpa proses komunikasi yang baik tidak akan tercipta kebaikan dalam setiap aktivitas, khususnya antara dan perawat dan pasien. Komunikasi terapeutik dilakukan dengan beberapa langkah, antara lain; Pase Pre-Interaction, Phase Orientation, Phase Work dan Phase Terminal dengan target optimalisasi tindakan pengobatan.