bluuebunny/crossref_metadata_2025 huggingface dataset:
«NARISTE» SCHOOL PREPARATORY PROGRAM IMPLEMENTATION AND A NEW TENDENCE IN THE EDUCATION SYSTEM IN THE KYRGYZ REPUBLIC
Authors:   Ministry of Education and Science of the Kyrgyz Republic, Ainekenova Anara , Mykyeva Mira ,   Ministry of Education and Science of the Kyrgyz Republic
Published: January 2024

The article is addressing the example of implementation of the “Nariste” school preparatory program (480 hours) as one of the areas of reforms in the Kyrgyz Republic, as well as one of the conditions for improving the quality of education as a whole, its accessibility due to new challenges and tendencies in the education system in the Kyrgyz Republic. The article discusses the current experience of introducing the assessment system in preschool education. The outcomes of participation in the Programme for International Student Assessment (PISA) in 2006 and 2009 had a particular impact on the development of preschool education system in the Kyrgyz Republic. In addition, the article discusses the pilot introduction of instruments for assessing the effectiveness of the Nariste program and the level of children's school preparation. The basic content of the article is about the tendencies in reforming the education system in the Kyrgyz Republic, the need for an analytical approach to reforming the system in a short period of time, and the importance of the "Nariste" school preparatory program under inaccessibility of early development programs for children. Eventually, the article shows the necessary conditions and areas for the achievement of any initiatives, for example, the transition to 12-year education, the introduction of an assessment system to improve the quality of education at all stages, so that all the reforms and efforts introduced experimentally in the practical processes of the education system in the country have not been conditional and unnecessary, but would help to move forward, in the right direction, given the age features of children, economic and social components of the whole process of different ideas, reforms, and the application of digital formats, public-private partnership approaches and per capita financing in preschool education.
VARIOUS APPROACHES TO THE DEFFENITION OF TRANSLATION AND CLASSIFICATION OF INTERPRETATION
Authors:   Ala-Too International University, Akimkanova Kunduz
Published: January 2024

This research paper is devoted to the analysis of various approaches in translation and the classification of its types in the context of modern linguistic and translation theories. Different approaches in translation may include comparison between languages, analysis of cultural characteristics and context, study of the structure and semantics of texts in different languages, as well as the use of computer technology in translation. The study of this topic allows us to expand our understanding of the diversity of translation practices and ways of analyzing them, which is a key element in today's globalized world, where interaction between different cultures and languages is becoming increasingly important. This work provides valuable research materials for linguists, translators, students, and all interested in the field of intercultural exchange and language interaction, contributing to a deeper understanding of the complexity and diversity of translation activities in the modern world.
FEATURES OF PERSONNEL TRAINING IN SECONDARY VOCATIONAL EDUCATION
Authors:   Salymbekov University, Junushalieva Nurzat , Kaldybaev Salidin ,   "Ala-Too" International University
Published: January 2024

The article is devoted to the issue of determining the purpose, role and place of secondary vocational education in the Kyrgyz Republic. It says that the training of highly qualified specialists, competitive in the labor market, well-educated, competent, creatively active, responsible, knowledgeable in their field, is one of the most important tasks not only of the education system, but also of society as a whole. The analysis of the works of scientists and normative documents on secondary vocational education is carried out. The problems that arise at this stage of education in the context of globalization and the need to solve them are due to the fact that the courses taught in educational institutions must meet the requirements of the labor market.
THE HISTORY OF THE STUDY OF FOLKLORE WORKS AS A SOURCE OF PATRIOTIC EDUCATION OF SCHOOLCHILDREN
Authors:   Kyrgyz State University named after I. Arabayev, Kaldybaeva Aychurek , Batirov Azizbek ,   Kyrgyz State University named after I. Arabayev
Published: January 2024

This article analyzes the history of studying the problem of patriotic education from the ethno-pedagogical side. The main attention is paid to the analysis of the ideas of the classical teacher, as well as the analysis of the works of Soviet teachers. The relevance of the article lies in the fact that the concept of patriotic education in folklore works is considered in connection with the materials of Kyrgyz folklore. The points set out in the article will be useful to those who conduct research in the ethno-pedagogical direction and conduct school education. Our awareness, education, professionalism, material and economic development should be accompanied by transparent morality, civilized behavior, internal spiritual culture. It became clear that society is only improving thanks to the conscience and responsibility of every citizen who is the motherland. With pure faith and a generous spirit, our society would have pure governance, pure creative work, peace, harmony and stability. Today, the primary task on the national scale and the necessary social needs of our society is the adoption of spiritual and moral education of citizens, future generations, the development and implementation of its concept, strategy.
FEATURES OF TRAINING SOCIAL EDUCATORS TO INTERACT WITH THE MODERN FAMILY
Authors:   Bishkek State University named after K. Karasaev, Kudaikulov Aibek
Published: January 2024

This scientific article analyzes the features of preparing social educators to work in interaction with families and discusses ways to implement their content in curricula and programs for teacher education. A social educator, first of all, needs to understand the opposites in the social environment and have the competence to resolve them in order to help improve the educational potential of the family. The family is a very vulnerable and supportive environment for the child, which maintains connections with society. Today, especially due to the fact that young families depend on social circumstances, the attention of the state and society to family education - changes in the social sphere, the development of science create the need to increase the level of professional competence of social teachers in family interaction. The basis of the scientific article is the peculiarities of the relationship between the social teacher and the family.
A study on the effect of walking tourists' benefits on happiness: The mediating effect of involvement and satisfaction
Authors:   The Tourism Sciences Society Of Korea, Moon Ji Young , Lee Hoon
Published: January 2024

Globally, the number of individuals participating in walking tours is continuously growing. However, besides some quantifiable outcomes or characteristics, little is known about the ultimate benefits or goals that tourists seek through walking tours. Particularly, a comprehensive study is needed to explore the ultimate benefits pursued by walking tourists (e.g., enhancing the quality of life) and a deeper understanding of how their happiness is achieved. This study aims to examine the relationship between the benefits of walking tourism and happiness, as well as the mediating role of involvement and satisfaction in the relationship. The data for this study were collected from the “Walking Tourism Status Survey Report” (Korea Tourism Organization, 2019) which surveyed 1,040 individuals who had experienced walking tourism in the previous year. The survey participants evaluated the benefits, involvement, satisfaction, and happiness associated with their walking tourism experience. The results indicate that health, social, and self-discovery benefits from walking tourism have both direct and indirect effects on walking tourists' involvement and satisfaction. Moreover, involvement and satisfaction partially mediate the relationship between walking tourists' benefits and happiness. Importantly, the impacts of involvement, satisfaction, and happiness vary depending on the benefits sought by walking tourists. Notably, self-discovery benefits lead to walking tourists' satisfaction and happiness only when involvement is present. This study is significant in the following aspects. It analyzes the benefits of walking tourism by using multidimensional measures that define and capture each benefit. This study also reveals pathways to satisfaction and happiness specific to the walking tourism benefits. It elucidates the relationship between walking tourism benefits and happiness, highlighting how the impacts on happiness vary based on the different benefits pursued by walking tourists. Finally, this study sheds new light on the role of involvement in the aforementioned process.
The impact of consistency, appropriateness, and authenticity in airline companies' ESG management initiatives on brand attitude and purchase intentions
Authors:   The Tourism Sciences Society Of Korea, Kim Ki-Bong , Lee Byeong-Cheol
Published: January 2024

This research has identified evaluation factors through a comprehensive literature review to empirically assess the influence of ESG (Environmental, Social, and Governance) management activities, as represented by perceived consistency, appropriateness, and authenticity, on brand attitudes and purchase intentions. In order to address potential inconsistencies in the minimum information levels of research participants, stemming from a limited understanding of ESG management activities within the airline industry, educational materials were developed. These materials, based on the airline's ESG management report, took the form of video educational content, incorporating visuals and voiceovers to cover various aspects of ESG management in the environmental, social, and governance domains. Prior to the survey, respondents were provided with the opportunity to review this content to enhance their comprehension of ESG management activities. Data collection was conducted among the general public who had experience using Airline D, spanning from October 22 to November 11, 2022. A total of 217 completed surveys were included in the research analysis, with 28 surveys excluded due to missing data. The research findings indicate that the public's perception of consistency, appropriateness, and authenticity concerning ESG management activities within the tourism industry has a positive impact on brand attitudes. Additionally, brand attitude positively influences purchase intentions. Notably, authenticity emerged as the most significant factor among the three, emphasizing the importance of companies' genuine efforts to enhance authenticity through substantive, practical actions, rather than superficial ESG management activities aimed solely at mitigating personal interests or addressing negative incidents. This aligns with stakeholders' long-term expectations for ESG management activities, reflecting a sincere commitment to the public interest.
Nostaljinin Derinliklerinde Kaybolup Giden Mekânlar: İzmir’in Deniz Hamamları
Authors: Taşkın Yasin
Published: January 2024

İzmir, kurulduğu ilk dönemlerden itibaren denizle iç içe bir kent olmuştur. Tarihsel süreçte idaresi altında tutulduğu devletler nezdinde hem bir liman kenti olarak hem de ticari ve askeri bir üs olarak önemini korumuştur. Kent, tarih boyunca kayda değer bir nüfusa ve canlı bir gündelik hayata ev sahipliği yapmıştır. Bu yüzden kentin zengin kültürü ve renkli sosyal ortamı vardır. Kent, halkın istifade edebileceği ve sosyalleşebileceği mekânlara sahip olmuştur. Bununla birlikte denizle iç içe olması sebebiyle halkın eğlence hayatında denizin önemli bir yeri vardır. Deniz hamamları da halkın gündelik yaşamında yer eden eğlence ve dinlence mekânlarından biridir. Buradan hareketle bu çalışmada bir dönem kentin gündelik yaşamında özel bir yeri olan deniz hamamlarından bahsedilmiştir. Deniz hamamları, bir dönem İzmirlilerin en fazla rağbet ettikleri sosyal mekânlardan biri olmuştur. Kullanış itibariyle günümüzdeki plajların öncüsü sayılmaktadır. Bu mekânlar sayesinde halk arasında denize girme alışkanlığı yaygınlaşmış ve günümüzdeki tatil kültürünün ilk nüveleri ortaya çıkmıştır. Çalışmada günümüzde kentte örneği bulunmayan bu mekânların gündelik yaşamda yeri ve önemine değinilmiştir. Zaman dilimi olarak Osmanlı Devleti’nin son dönemleri ile cumhuriyetin ilk yılları işlenmiştir. Çalışmanın teşekkülünde arşiv belgelerinden ve yıllıklardan faydalanılmıştır. Ayrıca kaynak niteliğinde kitap, anı türü eser ve süreli yayınlardan da istifade edilmiştir. Kentle alakalı yıllıklar ve raporlardan deniz hamamları ile ilgili kayıtlar incelenmiş ve çalışmada değerlendirilmiştir. Böylece deniz hamamları üzerinden eski İzmir’in gündelik yaşamından ve sayfiye kültüründen kesitler sunulmaya çalışılmıştır.
Mimosine concentration in giant leucaena (Leucaena leucocephala subsp. glabrata) fluctuates with age and plant part
Authors: Honda Michael , Borthakur Dulal
Published: January 2024

Giant leucaena is a multipurpose tree-legume found throughout the tropics and sub-tropics. Its foliage is used as animal fodder due to high protein and fiber. Giant leucaena has several other advantageous traits such as fast-growth, high yields and strong tolerance to environmental stresses. Despite having these desirable qualities, leucaena tissues contain an undesirable attribute, a toxic non-protein amino acid, mimosine, found in all parts of the plant including the foliage. The goal of this research was to determine mimosine concentrations in various tissues and life stages of giant leucaena plants to inform use of leucaena foliage as a fodder. Mimosine was extracted from different parts of giant leucaena at different ages and quantified using HPLC analysis. qRT-PCR was used to determine the relative expression of mimosine synthase in leucaena tissues. Mimosine was present in all parts of the leaf, stem and root of giant leucaena, and concentrations changed depending on the age of the plant. Green seeds had the highest expression level of mimosine synthase. Mimosine is ubiquitous and abundant in leucaena tissues with younger and immature plants and tissues containing more mimosine than older mature plants and tissues.
Optimization of Corrosion Behaviour of Blended TiO2 /ZnO Coating on SUS 304 using Taguchi Method
Authors:   Department of Mechanical Engineering, Government College of Engineering, Jalgaon, 425002, Maharashtra, India, Mahajan Vandana N , Sable M J , Shekhawat S P , Patil Suhas R
Published: January 2024

Objectives: To determine the best combination of blends of TiO2 /ZnO coated on SUS for obtaining a minimum corrosion rate. Methods: Different TiO2 /ZnO thin film blends are coated on SUS 304 substrates. The sol-gel dip-coating process is used for coating application. Also, withdrawal rates, calcination temperature, and doping percentage are the parameters used for the study of the anti-corrosion property. L9 array, using the Taguchi method, is applied for the design of the experiment. P.G-Lyte 1.0 model was used for the anticorrosion test. The Potentiosatic polarization method was applied for anti-corrosion testing. Findings: The results show that the percentage of ZnO doping (60%, 40%, and 20%) is the most significant factor in controlling the corrosion of the sample with plate number 1. The withdrawal rate (0.5 mm/sec, 1 mm/sec, and 1.5 mm/sec) has a minimal impact on the corrosion rate of the coated sample. The calcination temperature (300◦C, 400◦C, and 500◦C) has a greater impact than the withdrawal rate. There is a good agreement between the predicted and actual corrosion current. Novelty: Investigation of mechanical properties like corrosion resistance is essential for increasing the durability of automobile components by applying a coating of blends of TiO2 and ZnO with a rare blending combination that was not applied before for the investigation. In this research, efforts are made to reduce the corrosion rate by applying different blends of TiO2 and ZnO. Also, withdrawal rate and calcination temperature are varied in the process which was also not considered in the earlier studies. Keywords: Taguchi method; Corrosion current; Signal to Noise ratio; Coating; Design of experiments
Research Trends on Doctors’ Competencies in Korea Using Text Network Analysis
Authors: Kim Youngjon , Lee Jea Woog , Yune So Jung
Published: January 2024

We use the concept of the “doctor’s role” as a guideline for developing medical education programs for medical students, residents, and doctors. Therefore, we should regularly reflect on the times and social needs to develop a clear sense of that role. The objective of the present study was to understand the knowledge structure related to doctors’ job competencies in Korea. We analyzed research trends related to doctors’ job competencies in Korea Citation Index journals using text network analysis through an integrative approach focusing on identifying social issues. We finally selected 1,354 research papers related to doctors’ job competencies from 2011 to 2020, and we analyzed 2,627 words through data pre-processing with the NetMiner ver. 4.2 program (Cyram Inc., Seongnam, Korea). We conducted keyword centrality analysis, topic modeling, frequency analysis, and linear regression analysis using NetMiner ver. 4.2 (Cyram Inc.) and IBM SPSS ver. 23.0 (IBM Corp., Armonk, NY, USA). As a result of the study, words such as “family,” “revision,” and “rejection” appeared frequently. In topic modeling, we extracted five potential topics: “topic 1: Life and death in medical situations,” “topic 2: Medical practice under the Medical Act,” “topic 3: Medical malpractice and litigation,” “topic 4: Medical professionalism,” and “topic 5: Competency development education for medical students.” Although there were no statistically significant changes in the research trends for each topic over time, it is nonetheless known that social changes could affect the demand for doctors’ job competencies.
Application of Social Constructivism in Medical Education
Authors: Kim Youngjon
Published: January 2024

The purpose of this study is to discuss the main principles and concepts of social constructivism, examine the literature on the application of social constructivism in medical education, and explore the meaning and limitations of the utilization of social constructivism with learning theory. A literature search was carried out in two stages, utilizing PubMed, CINAHL and Education Source databases. The primary search included both fields (social constructivism AND medical education), while the secondary search was performed by subject (Vygotsky or ZPD or zone of proximal development or scaffolding AND medical education). A total of 96 papers were found through the primary and secondary searches, and after reviewing the abstracts of all 96 papers, 41 papers were deemed suitable for research purposes. In medical education, social constructivism is applied in areas such as (1) social and cultural behaviors (hidden curriculum), (2) social construct of “meaning” (dialogue and discourse), (3) learner’s identity transformation (expert), and (4) instructional intervention (ZPD and scaffolding). Social constructivism has provided many ideas to explore in terms of the composition of knowledge in the sociocultural context of health care, but it has not demonstrated an explicit instructional method or educational effects.
α-Synuclein aggregation monitored by thioflavin-T (ThT) fluorescence in a plate reader v1
Authors: Yuste-Checa Patricia
Published: January 2024

This protocol details how to efficiently monitor α-Synuclein aggregation by thioflavin T fluorescence in a plate reader.
Light-dark box test for mice v1
Authors: Novák Csilla , Mauricio Jaramillo Flautero Andrés , Prigge Matthias
Published: January 2024

This protocol describes the setup and execution of the light-dark box test for mice, a behavioral experiment used to assess anxiety-related responses. The protocol involves preparing a light-dark box in a controlled environment, utilizing specific lighting conditions and camera settings for optimal observation and recording.
Open field test for mice v1
Authors: Novák Csilla , Mauricio Jaramillo Flautero Andrés , Prigge Matthias
Published: January 2024

The open field test is a classical test for the quantification of locomotor activity and anxiety-like behaviors in laboratory animals. This protocol is optimized for mice, and it includes the automatic analysis of their movement by Biobserve Viewer. Higher amount of time spent next to the walls of the arena is associated with higher levels of anxiety.
Yeast immobilization in lignocellulosic wastes for ethanol production in packed bed bioreactor
Authors: Agudelo Escobar Lina María , Salazar Álvarez Uriel , Peñuela Mariana
Published: January 2024

This study is focused on the development of an immobilization process of yeast cells in waste lignocellulosic materials and their evaluation in the ethanol production by using packed bed bioreactors. We evaluated four different waste lignocellulosic materials: wood shavings, cane bagasse, corn cobs and corn leaves. The characterization made it possible to establish the microscopic structural differences between the four materials, as well as the differences in composition of lignin, cellulose, hemicelluloses and ash. A protocol for packaging materials and a quantification methodology of immobilized biomass was developed. An experimental design was conducted to determine the effects of the size of lignocellulosic materials on cell immobilization and to establish the effects of the flow rate in the immobilized cells when the fermentation is performed in packed bed bioreactors. Under the established experimental conditions we determined the size and flow rate that provided the better operational stability for the fermentation in packed bed bioreactor. The result of the study showed that the material in which the biggest amount of cells was immobilized was the sugar cane bagasse, and we obtained a value of 0.04657 dry immobilized biomass gX/gS (grams of dry biomass per grams of lignocellulosic material). This amount of immobilized biomass is significant compared to the values reported by other authors. As a result of the experimental design of the influence of flow and size of the carrier on the immobilization, it was established that there is no significant statistical difference in the range of the values used in the experiment (size of 3.4; 6.7 and 10 mm and flow rate of 0.36; 1.6 and 3.33 ml/s), so the best conditions for cell immobilization could be established taking into account the operational conditions and system stability. The size of the carrier selected was 3.4 mm and the flow rate of 0.36 ml/s...
Hydrochemical background of the Salar de Aguas Calientes I (Chile)
Authors: Garcés Millas Ingrid , López Julián Pedro
Published: January 2024

The salar “Aguas Calientes I” is a saline system located in the Chilean altiplane at 4.280 m.a.s.l, and exposed to arid climatic conditions. Chemistry of waters exposed in the salar surface has been studied in this work. During the field survey, several sectors with surficial waters were accurately located by means of GPS, and solutions in springs, wetlands, and saline ponds were sampled. Samples were adequately stored and carried to laboratory for chemical analysis. In several places, saline solid material was also collected for mineralogical analysis.
The main water inputs to the salar are situated in the northern and southern areas, this latter being thermal. Other inputs are the scarce precipitations that enter into the salar as surficial and/or subsurficial runoff. All these waters circulate towards the lowest areas of salar, being accu-mulated in several ponds along the western edge as consequence of a light tilting of salar surface.
The water chemistry indicate that all of them belong to the same chemical type, Na-Cl, despite the high dispersion in solute content. This is due to the interaction between solutions and underground saline deposits of salar, mainly composed of halite and gypsum. Moreover, concentrations of Li, B, and As were high for all samples, typical of waters related to hydrothermal activity. In the case of As all samples show concentrations above toxicity level, even in the most diluted. The non-thermal fresh spring waters outcropping in the northern margin flow towards the salar, feeding along their course an important wetland (locally named bofedal) and supplying fresh water to herds of camelids. On the contrary, waters present in central and southern areas of salar are highly concentrated in ponds without plants in their margins. Ponds are rimmed by saline minerals, whose mineralogical analysis together with physicochemical calculations on water chemical data indicate an active process of mineral precipitation involving halite and gypsum.
Power system capacity expansion planning model considering carbon emissions constraints
Authors: Mejía Giraldo Diego Adolfo , López Lezama Jesús María , Gallego Pareja Luis Alfonso
Published: January 2024

This paper presents a power system capacity expansion planning model considering carbon emissions constraints. In addition to the traditional technical and economical issues usually considered in the planning process, two environmental policies that consist on the taxation and the annual limits of carbon dioxide (CO2) emissions are considered. Furthermore, the gradual retirement of old inefficient generation plants has been included. The approach guarantees a cleaner electricity production in the expanded power system at a relatively low cost. The proposed model considers the transmission system and is applied to a 4-region and 11-region power systems over a 20-year planning horizon. Results show practical investment decisions in terms of sustainability and costs.
Decentralized power generation through biomass gasification: a technical – economic analysis and implications by reduction of CO2 emissions
Authors: Pérez Juan F. , Lenis Yuhan , Rojas Sandra , León Carlos
Published: January 2024

This article presents the feasibility analysis of two electricity generation projects with wood biomass. The first one considers a wood harvested for energy from a forest with pine plantation (case 1), and the second one, biomass residues from a teak plantation (case 2). Electric power that can be produced is 2.0 MWe for pine’s case, and 1.0 MWe for teak. Considering the power to generate and after a strict literature search and analysis, the most suitable electricity generation technology is thermo-chemical process of gasification coupled with combustion engines. Generation cost (USD/kWe-h) is calculated for each technological alternative with a technical-economic analysis, as result the lowest costs are approx. 0.061 USD/kWe-h for 1.0 MWe, and 0.058 USD/kWe-h for 2.2 MWe, assuming that biomass’ cost is zero (0 USD/ton). This is considered the baseline for electricity generation projects with biomass in Colombia. The research is complemented with a CDM projects applicability analysis, finding that the sale of Certified Emission Reductions (CERs) would reduce kWe-h cost between from 0.003 to 0.01 USD/kWe-h, in the studied power plants. However, neither the price neither the sale of CERs can be guarantee because there is not a tool to extend the Kyoto protocol, which comprises a first period between 2008 and 2012.
Advanced oxidation process H2 O2 /UV combined with anaerobic digestion to remove chlorinated organics from bleached kraft pulp mill wastewater
Authors: Botelho Ruas Diego , Rodríguez Chaparro Tatiana , Cleto Pires Eduardo
Published: January 2024

This study investigated the application of an advanced oxidation process combining hydrogen peroxide with ultraviolet radiation (H2 O2 /UV) to remove recalcitrant compounds from Kraft bleaching effluent. Anaerobic pre-treatment was performed to remove easily degraded organics using a horizontal-flow anaerobic immobilized biomass (HAIB) reactor. Bleaching plant effluent was treated in the HAIB reactor processed over 19 h of hydraulic retention time (HRT), reaching the expected removal efficiencies for COD (61 ± 3%), TOC (69 ± 9%), BOD5 (90 ± 5%) and AOX (55 ± 14%). However, the anaerobic treatment did not achieve acceptable removal of UV254 compounds. Furthermore, there was an increase of lignin, measured as total phenols. The H2 O2 /UV post-treatment provided a wide range of removal efficiencies depending on the dosage of hydrogen peroxide and UV irradiation: COD ranged from 0 to 11%, UV254 from16 to 35%, lignin from 0 to 29% and AOX from 23 to 54%. All peroxide dosages applied in this work promoted an increase in the BOD5 /COD ratio of the wastewater. The experiments demonstrate the technical feasibility of using H2 O2 /UV for posttreatment of bleaching effluents submitted to anaerobic pre-treatment.
Analysis and design of a low cost home automation prototype system
Authors: Barrera Durango Melisa , Londoño Ospina Nelson , Carvajal Jorge , Fonseca Alejandro
Published: January 2024

This paper shows the evaluation and alternatives selection aimed to design a low cost domotic prototype system for didactic applications, under the framework of an investigation project carried out at Universidad de Antioquia. Supported in the state of the art we show the selection criteria and the different elements of the designed system. At the beginning some characteristic of the selected communication protocol are showed; then the boards and interface design are explained. Finally, the obtained results are pointed in order to demonstrate the correct operation of the prototype.
hybrid optimization method for the transmission planning considering different voltage levels
Authors: Domínguez Andrés Hernando , Escobar Zuluaga Antonio , Gallego R. Ramón A.
Published: January 2024

In this article an alternative to solve the transmission network expansion planning problem taking the voltage level as a decision variable is presented. The idea is to benefit from the scale economies which appear when a circuit changes from a preestablished tension level to a higher tension level. Predefine the tension of the new circuits is less effective than taking the tension as one of the quantities that must be defined for the process of alternative’s evaluation. It is proposed a hybrid methodology to reduce the computational effort produced by the exponential growth caused for considering different voltage levels and investment alternatives. In this work, the meta-heuristic technique specifies where should be done the transmission line investments, meanwhile the heuristic techniques and the micro-genetic algorithm specifies the investment in new and existing substations. The developed methodology presented high-quality results.
Dynamic Location Model of Intermediate nodes within safety zones in focused logistics context
Authors: Kalenatic Dusko , López Bello Cesar Amílcar , González Leonardo José , Rueda Velasco Feizar Javier
Published: January 2024

This paper presents a mixed integer programming model for multiple logistics node location in order to support decision making processes as a function of combat units movement. The model let us to obtain a dynamic configuration for a supply network in operational logistics. With this purpose focused logistics concepts are employed as a last tendency for sustaining military operations. The model offers the possibility of use safety zones modeled as a spatial constrains which pretend to give warranties about survivability, operability, supplies continuity and flexibility in a hostile environment.
Topological optimization for solids under heat and mass transfer using boundary element
Authors: Mota Anflor Carla Tatiana , Vaz Goulart Jhon Nero , Marczak Rogério José
Published: January 2024

The objetive of this work is to present the implementation of a topological-shape sensitivity formulation in a BEM analysis for simultaneous heat and mass transfer optimization problems. The proposed approach uses a topological derivative in order to estimate the sensitivity to create a hole in the domain of the problem. Thus, it is evaluated at internal points, and the ones showing the lowest values are used to remove material by opening circular cavity. As the iterative process evolves, the original domain has holes progressively punched out until a given stop criteria is achieved. Since the sensitivities for each of the differential equations are different, a penalization-type approach has been used to weight the sensitivities associated to each problem. This allows the imposition of distinct penalization factors for each problem, according to specified priorities. The resutls obtained showed good agreement with solutions available in the literature.
Red derivacional de la palabra godín en el español de México
Authors: Zacarías Ponce de León Ramón
Published: January 2024

En esta investigación analizaremos el origen de la palabra godín, su estructura morfológica, su ampliación semántica y la red derivacional a la que ha dado lugar. Esta palabra se utiliza para referirse a un tipo de trabajador que se conoce también como burócrata. Son oficinistas que acuden en horario fijo a su lugar de trabajo; suelen llevar comida de casa y establecen camaradería con sus colegas de escritorio. Lo interesante de esta palabra es que ha dado origen a otras palabras derivadas que extienden el concepto y crean una red derivacional neológica. Entre las palabras que podemos mencionar se encuentran: godinato, godinazo, godinear, godinesco, godinista, entre otras. Una red derivacional permite extender un concepto, digamos nominal, para crear verbos, adjetivos y adverbios con rasgos semánticos semejantes pero distinto comportamiento gramatical. Asimismo, estos conceptos nuevos pueden crear a su vez nuevas palabras en un segundo orden de  derivación: por ejemplo, el sustantivo godín da lugar al verbo godinear, en un primer orden; a su vez, godinear se puede derivar, en un segundo orden de derivación en un nuevo sustantivo, godineo. En esta contribución demostraremos que esta nueva red derivacional es similar a otras que conforman palabras establecidas (Díaz-Negrillo, 2021), lo cual nos deja entrever que el entramado léxico está organizado de forma lógica y cíclica. Esto nos permite afirmar que el camino que sigue un concepto nuevo en su desarrollo léxico puede ser pronosticado hasta cierto punto.
Sobre el beber y la bebida en el Diccionario de autoridades
Authors: Martínez Lanzán Gloria
Published: January 2024

El término beber es ciertamente ambivalente puesto que vamos a referimos únicamente a la ingesta de bebidas alcohólicas y no al acto de beber agua, por ejemplo, para saciar la sed. Si en determinados momentos de la historia, principalmente el vino ha sido utilizado como alimento, pago por servicios o trabajo o como una forma de infundir ánimo entre las tropas o la marinería que iba en busca de nuevos mundos, también ha sido desde la antigüedad una forma de socializar cuyas consecuencias pueden ser previsibles o imprevisibles en función de la cantidad de bebida injerida. Todo ello se refleja en un léxico que se hace eco de las diferentes voces utilizadas para hablar de la bebida y su consumo, desde la abstinencia o la moderación al exceso. Nos remontamos al siglo XVIII en el que se publica el primer diccionario de la lengua castellana, el llamado Diccionario de Autoridades para comprobar las voces relacionadas con este campo léxico recogidas en el mismo y, posteriormente, constataremos su presencia o ausencia en la 23ª y última edición del actual diccionario de la Academia (DRAE).
How we treat polycythemia vera
Authors: Shuvaev V. A. , Martynkevich I. S.
Published: January 2024

Polycythemia vera is a disease known since ancient times, however, until recent decades, diagnosis was carried out by exclusion, and therapy was symptomatic. The discovery of the pathogenetic role of mutations in the Janus kinase II gene has led to the possibility of establishing a diagnosis based not only on morphology, but also on genetic verification and to the development of directed targeted therapy, which is much more effective than previously used methods. The introduction of molecular genetic screening led to the need for a differential diagnosis with familial erythrocytosis, and the lessons of the coronavirus pandemic revealed the presence in the population of a significant proportion of patients with erythrocytosis due to the carriage of gene polymorphisms associated with familial hemochromatosis. The article presents our own personalized algorithms for the diagnosis and treatment of polycythemia vera and the results of their use, demonstrating the possibility of a two-fold reduction in the incidence of thrombosis and an increase in overall survival.
The experience of relapsed Burkitt lymphoma treatment with targeted drugs and autologous/allogeneic stem cell transplantation
Authors: Valiev T. T. , Khachatryan A. A. , Goryacheva S. V. , Batmanova N. A. , Kirgizov K. I. , Varfolomeeva S. R.
Published: January 2024

The use of high-effective, multicomponent, risk-adopted chemoimmunotherapy schemes in children with Burkitt lymphoma reached advanced long-term progression-free survival over 90 % even for high risk patients. Unfortunately, conventional therapeutic strategy for relapsed/refractory disease is not accepted, and the effectiveness of carboplat‑in- and gemcitabine-containing regimens is unsatisfactory. Clinical experience of rituximab, ibrutinib and nivolumab in combination with polychemotherapy and own clinical case of successful relapsed Burkitt lymphoma treatment with targeted therapy and following autologous and allogeneic hematopoietic stem cell transplantation are presented. Proposed program could achieve a complete remission of Burkitt lymphoma, but short-term after allogeneic hematopoietic stem cell transplantation diagnosed T-cell precursor acute lymphoblastic leukemia became fatal for the patient.
Monoclonal immunoglobulin as a prognostic factor for the severity of bone damage in paraproteinemic hemoblastoses and Waldenström’s macroglobulinemia
Authors: Pisarevskaya O. N. , Alekseev S. A. , Rukavitsyn O. A.
Published: January 2024

Aim. Identify risk factors for the development of osteodestructive syndrome. To determine the relationship between the types of secreted monoclonal immunoglobulin (paraprotein) and the severity of osteodestructive syndrome in patients with paraproteinemic hemoblastoses (PH) and Waldenström’s macroglobulinemia (WM).

Materials and methods. A retrospective analysis of data from 116 patients with PH and WM was performed. 104 patients (89.6 %) were diagnosed with multiple myeloma. Less commonly observed were WM (in 8 patients – 6.9 %), plasma cell leukemia (in 2 patients – 1.8 %), solitary plasmacytoma and monoclonal gammopathy of unknown significance were diagnosed in one case (0.9 %) each. According to the severity of osteodestructive syndrome, all patients were divided into 4 groups. The first group (0) included patients who did not have osteodestructive changes in the bones. In patients of the second group, a mild degree (I) osteodestructive process was observed, and in patients from the third and fourth groups – moderate (II) and severe (III) degrees, respectively. All patients underwent protein electrophoresis followed by immunofixation to determine the type of paraprotein and its concentration in serum and urine.

Results. In the majority of patients, paraproteins were detected in the blood – Gκ (35.1 %), Gλ (24.6 %), Bence Jones protein λ-type (BJλ) (14.9 %); in urine – BJλ protein (14.9 %) and Bence Jones protein κ-type (BJκ) (28.1 %). Secretion of other types of paraproteins in the blood was less frequently detected – Aκ (9.6 %), Aλ (7.0 %), Mκ (3.5 %), Mλ (3.5 %), Dλ (2.6 %), BJκ (4.4 %). Osteodestructive syndrome of I and II severity was diagnosed in 43 (37.1 %) and 40 (34.5 %) patients, respectively; lytic destruction of III degree was less frequently detected in 20 (17.2 %) patients, in 13 (11.2 %) patients osteodestruction was not detected (degree 0). It was noted that a higher degree of destruction (II, III) was observed in patients with multiple myeloma occurring with paraproteinemia Dλ and BJλ in the blood, as well as hypercalcemia. Osteodestructive syndrome of the lowest degree (0, I) was diagnosed in patients with the secretion of monoclonal proteins Ak and Mλ. There was no statistically significant relationship between the type of secretion of paraproteins Gκ, Gλ, Aλ, Mκ, BJκ in the blood, as well as proteins BJκ and BJλ in the urine and the severity of the osteodestructive process.

Conclusion. The results obtained in the study make it possible to identify risk groups, and parameters such as the type of paraprotein, the concentration of calcium in the blood serum can be considered as prognostic factors when assessing the severity of osteodestructive syndrome in patients with PH and WM.
Hematological response in patients with paroxysmal nocturnal hemoglobinuria treated with C5-inhibitor
Authors: Latyshev V. D. , Fidarova Z. T. , Ponomarev R. V. , Tsvetaeva N. V. , Mikhaylova E. A. , Lukina E. A. , Parovichnikova E. N.
Published: January 2024

Background. Paroxysmal nocturnal hemoglobinuria is a rare clonal disease of the hematopoietic system, with the key manifestations of hemolytic anemia, a high thrombosis rate, and bone marrow failure. Despite the high efficacy of C5‑inhibitors in intravascular hemolysis cessation, a significant proportion of patients remain anemic. Causes of a sub‑optimal response may include C3‑mediated extravascular (intracellular) hemolysis, residual intravascular hemolysis, or bone marrow failure.

Aim. To analyze the results of pathogenetic therapy in patients with paroxysmal nocturnal hemoglobinuria.

Materials and methods. The study included 55 patients with paroxysmal nocturnal hemoglobinuria receiving complement C5 inhibitors for at least 6 months. Results. Suboptimal hematological response was observed in 31/55 (56 %) patients. The most common cause of anemia in the partial response group was C3‑mediated extravascular hemolysis in 8/10 (80 %), while bone marrow failure predominated (57 %) in the minor response group.

Conclusion. The study showed a high frequency of suboptimal response to pathogenetic therapy and necessity of ac‑curate determination of leading cause of persistent anemia in order to modify therapy or switch to other drugs.
Benefits of early antifungal therapy in hematology patients
Authors: Andreev S. S. , Bronin G. O. , Epifanova N. Yu. , Kozlova O. P. , Pristanskova E. A. , Khostelidi S. N. , Shadrivova O. V.
Published: January 2024

Invasive fungal infections (IFIs) are a serious threat to patients with hematological diseases. These infections are characterized by high mortality and lead to significant financial costs for treatment. The most common pathogens of IFIs are Aspergillus spp. and Candida spp., but in recent years, cases of infections caused by rare pathogens have become more frequent. Diagnosis of IFIs and choice of treatment remain challenging due to the nonspecificity of symptoms and the diversity of clinical cases. In this regard, the problem of start time and choice of antifungal therapy remains of current interest. This review briefly describes diagnostic criteria, challenges associated with IFIs diagnosing, provides evidence for empiric and preventive strategies as two early treatment approaches, and examines the impact of therapy initiation on patient outcomes. Treatment of IFIs in hematologic patients should be individualized. At the same time, early administration of therapy with broad-spectrum drugs for febrile neutropenia and parallel diagnostic measures can improve treatment outcomes. There is a lack of current data on the benefits of specific treatment strategies, highlighting the need for further research.
UNDECODED TRAGEDY OF THE NATION IN THE DRAMA POEM “CASSANDRA” FOREST UKRAINIAN
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Kovalev Yu.
Published: January 2024

The article highlights Lesya Ukrainka’s authorial interpretation of the ancient Greek plot of the Trojan War through the worldview of the soothsayer Cassandra, which foresaw the tragedy of her hometown, doomed to die by the Achaean invaders. In her dramatic poem, the author did not emphasize battle scenes, but psychological conflicts related to the problem of adequate vision and decoding of reality as it is, and not as it is thought or imagined, so the main character inevitably comes into conflict with others. characters who tend to be manipulated while living in an illusory world, unable to verify the information offered to them by the demagogue and pragmatist Helen, who paralyzes the trust of short-sighted Trojans. Parallels with the Ukrainian reality in which Lesya Ukraine lived and the beginning of the XXI century. – quite obvious. History has taught no one anything. However, the playwright did not fall into didactics and moralization, did not illustrate the past, as contemporaries believed, so she had to explain the essence of the dramatic poem, only showed a script-metaphor not so possible as an inevitable national tragedy, but Ukrainians will trust charming simulacra, not harsh. reality. She proposed a “drama of ideas” inherent in the “new drama”, a tense intellectual agon of the Priam House, developed the plot dynamics on the existential border, which is inherent in her dramatic poems, which failed then and current theaters, because they did not find, mistakenly fitting them into the genre category Lesendrama.
MUSIC IN POETRY, POETRY IN MUSIC LESYA UKRAINKA
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Naenko M. K.
Published: January 2024

The article is devoted to the musical element in the poetry of Lesia Ukrainka. The author analyses Lesia Ukrainka` s poems with musical motives (“Melodies” (Melodii), “Seven strings” (Sim strun), “Rhythms” (Rytmy)) and numerous texts set to music by different composers (M. Lysenko, K. Stetsenko, Y. Stepovyi, M. Verykivskyi,
Periodization of adaptation-compensatory remodeling of brain structures in incomplete permanent cerebral hypoperfusion in rats
Authors: Gaivoronsky Ivan V. , Chrishtop Vladimir V. , Nikonorova Varvara G. , Semenov Aleksei A. , Khrustaleva Yulia A.
Published: January 2024

Bilateral one-stage ligation of the common carotid arteries in rats is the most common method of forming prolonged cerebral hypoxia with cognitive impairment. Pharmacological studies are most commonly performed at the early postoperative periods, up to 3 days. They are characterized by neuronal death, hypoenergetic state, and edema. In the acute period (3–8 days), changes are associated with the activation of astrocytes, which form intercellular cooperation between the neuron, hemocapillary, and respiratory burst of neutrophil granulocytes. Thus, the permeability of the blood–brain barrier increases, accompanied by the death of one part of the neurons and the improvement of the vitality of another part. The subacute period (from 8 days to 8 weeks) is accompanied by the death of neurons in a state of poor life support, microglial activation, myelin fiber damage, increased diameter of paravertebral arteries in the early period, and the development of astrocytosis and angiogenesis in the late period, which leads to increased lipid peroxidation, secondary damage, and neuronal death. In the late period, neurodystrophic changes appear, and minor neuronal apoptosis and increased permeability of the blood–brain barrier persist. Surviving neurons show metabolic activation and concentration of pericarions near the hemocapillaries.