bluuebunny/crossref_metadata_2025 huggingface dataset:
STATISTICAL ASSESSMENT OF THE STATE OF EMPLOYMENT AND THE CREATION OF NEW JOBS IN THE JIZZAKH REGION
Authors: Norboyev  O‘razali  Muratovich
Published: September 2023

This article describes scientific proposals and practical recommendations for a positive solution to the problems of providing employment for the population of the Jizzakh region, the processes of creating new jobs, ensuring employment of the able-bodied population. In addition, a study was made of the socio-economic ties of improving the labor market in the context of macroeconomic stabilization of the economy of the Jizzakh region, ensuring employment of the population based on the actual demand and supply of labor. Taking into account that today the problem of ensuring employment of the population is becoming one of the global problems of the world, the economic and statistical analysis of employment of the population and the development of ways to eliminate the problem of employment in our country are growing every year. For this reason, we have carried out extensive scientific research on this issue in the context of the general theoretical rules and practical aspects of statistics. In this article, we have presented some of our scientific findings and suggestions from our study.
KEY WORDS : Macroeconomic sustainability, system of statistical indicators, methods of statistical analysis, GDP, industries, economic and social processes, trends, period changes, statistical reports, retrospective analysis, analysis and synthesis, expert assessment, induction and deduction, statistical tables and graphs , statistical grouping, scientific abstraction of time series and economic indicators.
The older, the wiser and also the less innovative? An empirical analysis of the relationship between population aging and innovativeness
Authors: Ruiu Gabriele , Breschi Marco , Fornasin Alessio
Published: September 2023

Entrepreneurship is generally considered the engine of growth, given its role in introducing innovations into the economic system. Developed countries have already become a victim of rapid aging of their populations, while the similar trend has just started in developing countries. The previous literature has suggested that aging and nascent entrepreneurship are negatively related. This study investigated the relationship between aging and innovation using dynamic panel techniques. We found that the level of innovation activities represented by the number of patent applications is negatively related to aging. This association remains even after other demographic and institutional confounders are taken into account. We also found that education and flexibility of business regulations are positively related to innovation.
Mathematical Modelling and Validation of Mitogenic Signaling Pathway in Breast Cancer
Authors:   , Meher Abinash
Published: September 2023

Applied Mathematics is becoming an integral part of predicting disease progression, including cancers. Mathematical models can be used to test novel hypotheses, develop optimized treatments schema and personalised therapies, and predict the outcomes. Remarkable advancements have been made in treating cancers, especially breast cancers. The phenomenal progress in computational capacities has helped make whole-genome sequencing rapid and affordable, enabling precision cancer therapy. There are many molecular drivers of breast cancer. Some of them define the breast cancer sub-types. The presence of estrogen receptor (ER, progesterone receptor (PR) and/or human epidermal growth factor 2 (HER2) or their absence defines the breast cancer subtypes and their treatment regimen. About 70% of the breast cancer diagnosed are ER/PR positive and are also known as hormone receptorpositive (HR+) breast cancer. The prognosis and treatment response of HR+ breast cancer is good for patients undergoing endocrine therapy. Despite the better prognosis of HR+ breast cancer, the recurrence rate and resistance to endocrine therapy is observed in many HR+ breast cancer cases. The resistance to endocrine therapy and recurrence is partly attributed to the activation of the insulin pathway and independent of HR+ breast cancer cells on ER pathway for their growth. Earlier, the crosstalk between insulin and ER pathways was demonstrated. N-myristoyltransferase (NMT) exists in human in two isoforms (NMT1 and NMT2) that catalyzes myristoylation reaction. Recent research from out laboratory has shown that NMTs are vital players in the pathogenesis of JR+ breast cancer. Furthermore, it was also demonstrated from previous studies from our laboratory that NMTs are downstream targets of insulin and ER pathways. In this thesis, I have designed mathematical models using differential equations to study the activation of the insulin pathway and its effect on NMT. The mathematical modeling incorporated the partition of cellular organelles and the sequential flow of information with cascades of equations representing signaling reactions. The activated mathematical model was designed by activating the insulin receptor (IR) or insulin-like growth factor receptors (IGF1R) and compared with the control model. The mathematical models were validated by wet-lab experiments. The HR+ breast cancer cells, MCF7 cells, were treated with insulin of IGF1 for the short-term and long-term. The status of the pathway proteins in terms of expression, localization and activity were determined by cell fractionation and Western analysis. The results revealed the correlation between the differential expression patterns of NMT and the proliferation of MCF7 cells when the insulin pathway was activated by insulin or IGF. The mathematical modeling was validated by simulations and data fittings. The results demonstrated that differential equation based mathematical modeling could predict the NMT related oncogenic changes in ER+ breast cancer cells.
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF MENGGUNAKAN ARTICULATE STORYLINE 3 PADA TEMA 8 LINGKUNGAN SAHABAT KITA
Authors: Suci Lestari  , R. Teti Rostikawati  , Abdul Gani Resyi Abdul Gani
Published: September 2023

Development of Interactive Learning Media Using Articulate Storyline 3 on Theme 8 The Environment of Our Friends. This study aims to develop and determine the feasibility of interactive learning media Articulate Storyline 3 theme of the environment of our friends subtheme of humans and the learning environment 2. This study uses the type of Research and Development (R&D) studies, these research and development steps use the ADDIE model with 5 stages consisting of Analysis, Design, Development, Implementation and Evaluation stages. This research was implemented at SDN Bantarkemang 1 with class V as the research subject. The data collection techniques used were interviews, observations, questionnaires, and documentation. The feasibility of the media products developed obtained a percentage of 83% media experts, 100% language experts, and 94% material experts with very feasible criteria. While the students response was 96,64%, the user response (teacher) was 97,77%, and the N-Gain score obtained was 0,56 with a moderate category, which means that the media products developed are effective enough to be used in learning. Based on the results of the study, it can be concluded that the interactive learning media Articulate Storyline 3 developed in the study proved feasible and effective enough to be used during learning.
PENANAMAN KARAKTER PEDULI LINGKUNGAN MELALUI GERAKAN 5S PADA SISWA DI SDN BUGANGAN 03 SEMARANG
Authors: Rika Erlinawati  , Qoriati Mushafanah  , Duwi Nuvitalia  , Intan Octavira Pitarti
Published: September 2023

ABSTRAK

Rika Erlinawati NIM : 2253A121227. Judul Penanaman Karakter Peduli Lingkungan Melalui Gerakan 5S Pada Siswa di SDN Bugangan 03 Semarang. Artikel, Program Pascasarjana, Pendidikan Profesi Guru, Universitas PGRI Semarang. Pembimbing I Qoriati Mushafanah, S.Pd., M.Pd. Pembimbing 2 Duwi Nuvitalia, S.Pd., M.Pd. Guru Pamong Intan Octavira Pitarti, S.Pd.SD.

 

Penelitian Kualitatif ini bertujuan untuk mengetahui bagaimana cara penanaman nilai karakter peduli lingkungan pada siswa. Penelitian ini dilaksanakan di SDN Bugangan 03 Semarang. Kegiatan yang dilakukan dan menjadi pembiasaan dalam membentuk karakter peduli lingkungan pada diri siswa dilakukan melalui kegiatan rutin harian, mingguan dan sewaktu-waktu. Kegiatan pembentukan karakter peduli lingkungan pada diri siswa yang dilakukan sewaktu-waktu adalah pembiasaan dengan Gerakan 5S (Gerakan 5 menit memungut sampah) untuk menjaga kebersihan sekolah yang dilakukan oleh seluruh warga sekolah. Kegiatan ini efektif dalam menanamkan nilai karakter peduli lingkungan pada seluruh siswa di SDN Bugangan 03 Semarang karena tidak terdapat sikap siswa yang belum sesuai dengan arah tujuan pembentukan nilai-nilai utama karakter, guru selalu melakukan pembinaan secara berkelanjutan sehingga pembentukan nilai karakter peduli lingkungan menjadi pembiasaan dan budaya hidup siswa di SDN Bugangan 03 Semarang.

 

Kata Kunci : Karakter, Peduli lingkungan
ANALISIS KEAKTIFAN BELAJAR PESERTA DIDIK DENGAN MODEL PROBLEM BASED LEARNING (PBL) PADA PEMBELAJARAN TEMATIK KELAS II SEKOLAH DASAR
Authors: Nisva Auliya  , Qoriati Mushafanah  , Henry Januar  , Intan Octavira Pitarti
Published: September 2023

ABSTRAK

Penelitian ini bertujuan untuk menganalisis keaktifan belajar peserta didik dengan model Problem Based Learning (PBL) pada pembelajaran tematik di kelas II D SDN Bugangan 03 Semarang. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan pengambilan data melalui observasi, wawancara, dan dokumentasi. Analisis data yang digunakan melalui tahapan reduksi data, penyajian data, dan penarikan kesimpulan. Dari hasil penelitian ditemukan bahwa penerapan model pembelajaran Problem Based Learning (PBL) dapat meningkatkan keaktifan belajar peserta didik pada pembelajaran tematik di kelas II D SDN Bugangan 03 Semarang.

 

Kata Kunci: keaktifan, PBL, tematik
Prevalence of mutations associated with macrolide and fluoroquinolone resistance in Neisseria gonorrhoeae with Allplex™ NG&DR Assay (Seegene®) in a tertiary hospital from Madrid, Spain
Authors: Maldonado-Barrueco Alfredo , Sanz-González Claudia , Falces-Romero Iker , García-Clemente Paloma , Cacho-Calvo Juana , Quiles-Melero Inmaculada
Published: September 2023

Background. The prevalence of drug-resistant Neisseria gonorrhoeae (NG) infections is increasing. Studies report the prevalence of NG strains presenting A2059G/C2611T (rRNA 23S) and S91F (parC) mutations conferring resistance to azithromycin and ciprofloxacin. Material and methods. We conducted a prospective cohort study evaluating first void-urine urines, rectal, and oropharyngeal swabs collected from a cohort of patients in a tertiary hospital in Madrid between October 2022 and January 2023. Samples were screened by Allplex™ 7-STI Essential Assay (Seegene®). Drug resistances were performed by Allplex™ NG&DR Assay (Seegene®). Results. A total of 1,415 patients were included, of which 112 had a positive sample for NG infection. One patient had a C2611T mutation (0.9%) and neither patient showed A2059G mutation. We found 67 (59.8%) S91F-positive patients. Forty-four patients (39.3%) not had any mutations. Conclusions. We report a low-prevalence of mutations A2059G/C2611T to macrolides and a high-prevalence to S91F in NG infections. Molecular methods for the detection of NG resistance could be useful in direct non-culturable samples.
The Effect of Endorphin Massage on the Intensity of Back Pain in Mothers During Active Phase I in Labor in Tegallega Village, Warungkondang District, Cianjur Regency, Indonesia
Authors: Rika Dwi Mustika  , Mustari Paramita
Published: September 2023

Childbirth is a physiological process or the process of expelling viable products of conception from the uterus to the outside world, thus enabling the mother to give birth to her fetus through the birth canal. There are several aspects related to pain during labor and can affect the birth process itself. Treatment uses non-pharmacological methods such as relaxation, warm compresses, yoga and one of which is using massage methods to reduce pain, one of which is back massage and endorphin massage.  This study aimed to find out the effect of endorphin massage on the intensity of back pain in laboring mothers during the first active phase in Tegallega Village, Warungkondang District, Cianjur Regency. This study is an experimental research with a one group pre-test post-test design. This research only involves one group of subjects who will be observed before and after the intervention. The average intensity of pain before endorphin massage was given to mothers giving birth was 8.23. Meanwhile, the average value of the intensity of back pain in women giving birth after being given endorphin massage was 7.23. This shows that the intensity of back pain in mothers giving birth during the first active phase before endorphin massage was given to mothers giving birth during the first active phase in Tegallega Village decreased. There is an effect of giving endorphin massage on the intensity of back pain in mothers giving birth during the first active phase.
Analysis of the Determinants of Exercise Habits, Diet, and Heredity History with the Incidence of DM in Productive Age at Tirto 1 Health Center, Pekalongan Regency, Indonesia
Authors: RM Dewi Nugraheni , Anisah Maulida  , Aris Santjaka
Published: September 2023

Degenerative disease in the form of diabetes mellitus which spreads to the elderly because there is a decrease in the function of the body's organs. The industrial revolution 4.0 affects diet and lifestyles which are estimated to increase the risk of diabetes mellitus in productive age. This study aimed to determine the relationship between exercise habits, diet and hereditary history with the incidence of diabetes mellitus in productive age. The research was carried out in April - May 2023 on 51 respondents each with analysis techniques using the Chi – square test and logistic regression. The results of the study showed that there was no relationship between exercise habits (p =0.269, OR=3.267), there is a relationship between diet based on food ingredients including the variable carbohydrate consumption habits (p =0.001, OR = 6.3), and soft drinks (p = 0.031, OR = 5.976) which is a risk factor. While animal protein (p= 0.001, OR=0.001), vegetables (p=0.003, OR = 0.17), fruits (p= 0.003, OR = 0.26) is a protective factor. The results of the analysis of food ingredients that did not show any relationship with the incidence of diabetes mellitus (DM) in productive age included vegetable protein (p = 1,000, OR = 1,000), dairy (p = 1,000, OR=1,000), nuts (p = 0.454, OR=1.654) and snacks (p = 0.523, OR = 1.87) as well as family history (p = 0.029, OR=2.636). Apart from that, it was found that there was a relationship between hereditary factors and the incidence of DM in productive age and became a risk factor in the research. In conclusion, protein is the most dominant influencing variable and protective factor in this research.
Effects of Public Debt on Interest Rates in Selected East African Community Member States
Authors: Maugu Lenity Kananu , Korir Julius , Kosimbei George
Published: September 2023

East African Community member states have embarked on various strategies to reduce interest rates in the region to boost investment so as to accelerate economic growth. However, despite the many reforms, the interest rates are far higher than in other countries in Africa, which are more developed. In an attempt to bolster investment, these states have increased public debt rapidly, exceeding the debt ratio of 50 per cent of Gross Domestic Product as provided in their treaty. The main objective of this study was to examine the effects of public debt on interest rates in selected East African Community member states. The study was anchored on the loanable fund model and used a descriptive panel research design. The dataset was drawn from World Development Indicators and Penn World Tables for the period 1980 to 2020. The dataset was drawn from secondary sources: World Bank's World Development Indicators, Penn World Tables, Economic Surveys and Statistical Abstracts for the period 1980 to 2020. The Panel Autoregressive Distributed Lag method was used to analyse the study. The study found that public debt had a positive effect on the long-term interest rate in the five countries combined. Therefore, these governments need to take effective measures to pursue fiscal discipline. Additionally, EAC states can use concessional loans, which have more favourable terms like lower interest rates, deferred repayments, and income-contingent repayments
Assessment of the Influence of Contextual Issues in Evaluating eHealth Systems Usability in Tanzania
Authors: Kavuta Karisha , Msanjila Simon , Shidende Nima
Published: September 2023

The adoption of eHealth systems in healthcare facilities has rapidly increased in many countries. However, the main challenge has been the quality and level of usability of those adopted systems, and the complexity of the challenge varies from one country to another based on contextual issues. Usability is also linked to contextual issues, which have a direct impact on deciding the methods for providing services on similar systems. This research focuses on assessing the influence of contextual issues on metrics that are applicable for evaluating the usability of eHealth systems through a case study of Tanzania. The findings of this research were obtained through the quantitative method, and the analysis was performed through structural equation modelling (SEM) using AMOS and SPSS applications. It is evident from this research that contextual factors, such as user characteristics, goals and tasks, technical environment, physical environment, and resources and technology, significantly impact the usability metrics that are important to the evaluation of eHealth systems. The usability metrics for eHealth systems identified in this research include navigation visibility, accessibility, perceived ease of use, error correction, internal collaboration, information quality, external collaboration, technical quality, guide and support, and perceived benefits. This study also revealed that the usability evaluation of eHealth systems should consider both common metrics and specific metrics in order to uncover both general information system and health context-specific usability issues
Ejection fraction, B-lines, and global longitudinal strain evaluated with rest transthoracic echocardiography to assess prognosis in patients with chronic coronary syndromes
Authors: Cortigiani Lauro , Orsino Maria Francesca , Favilli Marco , Bovenzi Francesco
Published: September 2023

Aim: Transthoracic echocardiography (TTE) is the first-line imaging test for patients with chronic coronary syndrome (CCS) and the cornerstone of risk stratification is left ventricular (LV) ejection fraction (EF). Aim of the study was to investigate the value of TTE supplemented with strain echocardiography (STE) and lung ultrasound (LUS) to assess the risk of patients with CCS.
Methods: In a prospective, single-center, observational study, from November 2020 to December 2022, 529 consecutive patients with CCS were recruited. All patients were evaluated at rest. A single vendor machine (GE Vivid E95) was used. EF with biplane Simpson’s method (abnormal cut-off < 50%), LV global longitudinal strain (GLS%, abnormal cut-off ≤ 16.2% by receiver-operating characteristics analysis) by STE, and B-line score (abnormal cut-off ≥ 2) by LUS (4-site simplified scan) were assessed. Integrated TTE score ranged from 0 (all 3 parameters normal) to 3 (all parameters abnormal). All patients were followed-up and a composite endpoint was considered, including all-cause death, acute coronary syndrome (ACS), and myocardial revascularization.
Results: During a follow-up of 14.2 months ± 8.3 months, 72 events occurred: 10 deaths, 11 ACSs, and 51 myocardial revascularizations. In multivariable analysis, B lines [hazard ratio (HR) 1.76, 95% confidence Interval (CI) 1.05–2.97; P = 0.03], and GLS ≤ 16.2% (HR 2.0, 95% CI 1.17–3.45; P = 0.01) were independent predictors of events. EF < 50% was a significant predictor in univariate, but not in multivariable analysis. Event rate at 2 years increased from score 0 (8%), to score 1 (21%), 2 (23%), and 3 (40%), P < 0.0001.
Conclusions: TTE with left ventricular ejection fraction (LVEF) can be usefully integrated with STE for GLS, and LUS for B-lines, for better prediction of outcome in CCS. The 3 parameters can be obtained in every echo lab with basic technology, no harm, no risk, and no stress.
On The Application Of Gibbs Equations In Determining The Relationships Of Vapour Pressures To Phase Diagrams Of The Reactive Chloride Systems
Authors: Kipouros A. A. , Jarjoura G. , Kipouros G. J.
Published: September 2023

Most of the phase diagrams reported in the literature have been determined in open atmospheric conditions indicating that the substances involved are not influenced by the presence of air and moisture. In these cases, the Gibbs phase rule is applied in its open condition of 1 atm pressure, and no special conditions need to impose. However, for many elements, such as all reactive metals, the phase diagrams are determined by conditions imposed to remove all the reactive actions of the presence of an atmosphere. In these cases, a special cell is needed to be constructed in a way that the material of construction of the cell and the absence of air is secured. The Gibbs phase rule is applied in its full mathematical formulation in those cases. The present publication reports on the determination of correct conditions to obtain meaningful results on the phase diagrams.
Synergistic Training: Harnessing Active Learning and Pseudo-Labeling for Enhanced Model Performance in Deep Learning
Authors: Oh Seongjin , Jeong Jongpil , Lee Chae-Gyu , Yoo Juyoung , Nam Gyuri
Published: September 2023

This research addresses the growing need for efficient data labeling methods by leveraging deep learning models. The proposed approach combines pre-training and active learning to automate the labeling process and reduce reliance on human annotators. In the pre-training phase, two deep learning models are trained using labeled data, adjusting the data ratio to ensure approximately 50% accuracy on the test set. In the active learning phase, the models generate pseudo labels for unlabeled data based on a confidence threshold, and the selected data is used to improve the models' performance through alternating epochs. The experimental results demonstrate the effectiveness of the approach, achieving significant improvements in accuracy compared to traditional methods. This research contributes to the trend of using deep learning for efficient data labeling and offers a promising solution for reducing the time and cost associated with manual annotation.
Are there sex differences in spatial reference memory in the Morris water maze? A large-sample experimental study
Authors: Zorzo Candela , Arias Jorge L. , Méndez Marta
Published: September 2023

Sex differences have been found in allocentric spatial learning and memory tasks, with the literature indicating that males outperform females, although this issue is still controversial. This study aimed to explore the behavior of male and female rats during the habituation and learning of a spatial memory task performed in the Morris Water Maze (MWM). The study included a large sample of 89 males and 85 females. We found that females searched slightly faster than males during habituation with a visible platform. During learning, both male and female rats decreased the latency and distance traveled to find the hidden platform over the days, with males outperforming females in the distance traveled. Females swam faster but did not find the platform earlier, suggesting a less directed navigational strategy. Both sexes increased time spent in the target zone over the days, with no sex differences. Although females swam more in the periphery during the first days of the task, both sexes decreased the time spent in this area. Finally, only males increased swimming in the pool's center over the days, spending more time than females in this area across the entire training. In conclusion, we need to register several variables in the MWM and analyze path strategies to obtain more robust results concerning sex differences. Research on spatial learning should include both sexes to achieve a more equitable, representative, and translational science.
The impact of spatial and verbal working memory load on semantic relatedness judgements
Authors: Khanzhyn Dmytro , van Heuven Walter J. B. , Rataj Karolina
Published: September 2023

Studies using a relatedness judgement task have found differences between prime-target word pairs that vary in the degree of semantic relatedness. However, the influence of working memory load on semantic processing in this task and the role of the type of working memory task have not yet been investigated. The present study therefore investigated for the first time the effect of working memory load (low vs. high) and working memory type (verbal vs. spatial) on semantic relatedness judgements. Semantically strongly related (e.g., hip – KNEE), weakly related (e.g., muscle – KNEE) and unrelated (e.g., office – KNEE) Polish word pairs were presented in an experiment involving a dual working memory and semantic relatedness task. The data revealed that, relative to semantically unrelated word pairs, responses were faster for strongly related pairs but slower for weakly related pairs. Importantly, the verbal working memory task decreased facilitation for strongly related pairs and increased inhibition for weakly related pairs relative to the spatial working memory task. Furthermore, working memory load impacted only weakly related pairs in the verbal but not in the spatial working memory task. These results show that working memory type and load influence semantic relatedness judgements, but the direction and size of the impact depend on the strength of semantic relations.
RETROSPECTIVE ANALYSIS OF THE WORD “DIGITALIZATION”
Authors: Voitsekh Vladyslav O.
Published: September 2023

Digitalization is rapidly changing the assumptions of the way of organization of work and life work and digital practices are changing business landscapes. While the use of data in business-to-business marketing is not a new phenomenon, the digitization and digitalization of firms' business models have recently attracted a great deal of attention. There is a wave of “digitization” in many parts of the world as private businesses, as well as the public sector, embrace information and communication technologies to achieve lesser cost, efficiency, and competitive advantage. However, what we are witnessing is just the beginning of an economic revolution as the full potential of the digital economy is about to be harvested. Nevertheless, this question should be studied more in the future. At the same time, the concept of digitalization in the literature has many meanings and is used in different ways. Consistent communications can make future conversations easier because the definitions are concrete, discussions about misunderstandings and ambiguities are avoided, and trust is built. The research tries to clarify the concept by giving an overview of the existing theory and terms, explains the differences between them based on the recent research on this topic, and specifies the importance of these digital processes in the modern world. The main finding is the meaning of digital transformation, which is not only about powerful technologies but also about resources and people in the first way.
Ebeveynler ve Online Sağlık Bilgisi Arama Davranışı: Sağlık Okuryazarlığı Kapsamında Bir İnceleme
Authors: EYÜBOĞLU Ezgi
Published: September 2023

Dijitalleşme, hayatın her alanını kuşattığı gibi, toplumun sağlıkla ilgili tüm pratiklerini de etkisi altına almaktadır. Bu bağlamda, ebeveynler tarafından çocukları ile ilgili sağlık bilgisine ulaşmada sıklıkla tercih edilen bir kaynak konumunda olan dijital medyadaki içerikler, önem taşımaktadır. Sağlığın geliştirilmesine yönelik üretilen ve tasarlanan içeriklerde kaynağın uzmanlığı, bilginin güncelliği, mesajın etkinliği ve medya ortamının dinamikleri kadar toplumun sağlık okuryazarlık düzeyine uygun bilginin paylaşılması da kritik bir rol oynamaktadır. Sağlık bilgisinin kolay anlaşılır ve bireylerin bilgi gereksinimini karşılayacak bir dil ve nitelikte olması, sağlık okuryazarlığının yaygınlaşmasını ve uzun dönemde bireylerin sağlıklarını koruma ve sürdürme noktasında doğru davranışlar sergilemelerini sağlayabilmektedir. Bu çalışmada, ebeveynlerin çocuklarının sağlığıyla ilgili kullandığı dijital içeriklerin işlevsel sağlık okuryazarlık düzeyi açısından incelenmesi hedeflenmektedir. Bu doğrultuda, amaçsal örnekleme yolu ile belirlenen 34 WEB sitesi içerik analizi tekniği ile işlevsel sağlık okuryazarlığı düzeyine karşılık gelen okunabilirlik ve sağlık bilgisinin içeriği ve kalitesi açısından değerlendirilmiştir. Analiz sonucunda online sağlık bilgisi kaynaklarının ‘orta güçlükte’ okunabilir olduğu, içeriğin güvenilirlik ve kalite düzeyinin yetersiz olduğu saptanmıştır
Factores Asociados a la Adherencia al Tratamiento Farmacológico en Pacientes con Hipertensión Arterial en la Parroquia Palanda, Año 2018
Authors: Abad Castillo María Luisa , Angamarca Angamarca Gloria Patricia , Pardo Vasquez Diego Fernando
Published: September 2023

La Introducción: La hipertensión arterial es una importante causa de morbimortalidad a nivel mundial, por lo que su control resulta imperioso. Los pacientes hipertensos ameritan atención sanitaria multidisciplinaria, así como el seguimiento minucioso del tratamiento, puesto que, se estima que su adherencia a la terapia farmacológica es de 50%. Objetivo: Determinar los factores asociados a la adherencia al tratamiento farmacológico antihipertensivo. Metodología: Estudio observacional, descriptivo, transversal, prospectivo, mediante el cual se realiza una entrevista a los pacientes hipertensos, que acuden al Centro de Salud de Palanda, quienes responden un cuestionario, un test de medición de adherencia y se les mide la presión arterial, para establecer la relación que existe entre los factores evaluados y la adherencia. Conclusión: Conocer los factores asociados a la adherencia terapéutica es prioritario para controlar la hipertensión arterial y con ello aumentar la calidad de vida de los pacientes
Diagnóstico y Percepción de los Jóvenes Universitarios y las Autoridades de Seguridad Ciudadana de la Ciudad de Oruro
Authors: Calani Carrión Elisabet , Arce Bustamante Zulema Inés
Published: September 2023

En Bolivia, en los últimos años el número de casos de inseguridad ciudadana han aumentado notablemente, dentro de ella una comunicación deficiente influye en la confianza de los jóvenes universitarios hacia las autoridades de seguridad ciudadana. Este artículo presenta las principales causas de desconfianza hacia esta institución y cómo es que la comunicación influye en ella, por otro lado, se da conocer las estrategias comunicacionales que aplican las autoridades de seguridad ciudadana, con datos certeros. A través de este estudio, damos a conocer la importancia de la comunicación en ámbitos de la seguridad ciudadana, siendo que es un tema sumamente importante en nuestro cotidiano vivir, resaltando que nuestras relaciones humanas son efectivas cuando la comunicación es empleada de manera correcta, teniendo en cuenta que tal es indispensable en todos los ámbitos de nuestra vida.
La Comunicación Intergeneracional: La Conformación de los Estereotipos y Prejuicios Acerca de la Identidad de Género
Authors: Choque Flores Najheli Alejandra , Sanjinéz Arancibia Celmira
Published: September 2023

Cada sociedad tiene una estructura interna, en esta se establecen patrones de: Creencias, actitudes y conductas que condicionan la integración y desarrollo de los individuos. El conjunto de personas que forma parte de la misma, tienden a crear estereotipos que norman las ideas y conductas dentro de lo que consideran aceptable, así mismo se encargan de categorizar y posicionar a cada individuo de acuerdo a un rol asignado dentro del sistema social. La conformación de individuos con distintas creencias sociales origina alteraciones en las formas de relacionamiento; tal es el caso de la identidad de género, la libre expresión de la orientación e identidad de género ocasiona desigualdades sociales.  El objetivo es analizar la comunicación intergeneracional, respecto a la identidad de género, identificando los estereotipos sociales y prejuicios individuales para buscar soluciones ante un problema que afecta a un sector de la población orureña.  La metodología, se enfocó en un estudio descriptivo, analítico experimental; utilizando un muestreo no probabilístico, basándonos en un proceso de metodología mixta, cualitativo-cuantitativo; se aplicó la misma para la recolección de la información diferentes encuestas y entrevistas, obteniendo como resultado que la sociedad independiente de la edad, llega a tener prejuicios y estereotipos con las personas de identidad de género.
Seguridad en obras de construcción civil. Charlas de Seguridad-EPP’S y Normas ISO
Authors: Santillán Guzmán Katherin
Published: September 2023

Seguridad en obras de construcción civil. Charlas de Seguridad-EPP’S y Normas ISO
The Effect of Physical Training and Shuttlecock Shot Practice on Smash Power in Badminton
Authors: Ricardo Ricardo
Published: September 2023

This article discusses the effect of physical training and shuttlecock hitting practice on smash power in badminton. The object of this research is every individual who often plays badminton, especially for those students who specifically play badminton. The purpose of this study was to determine the effect of physical training and shuttlecock practice on smash strength either partially or simultaneously. The method used is quantitative with path analysis analysis tools. The population is 125 authors with a sample of 50 authors. The type of sampling used is accidental sampling. The data analysis tool used path analysis and IBM SPSS version 27. The data analysis technique used was R square analysis, t test and f test. Questionnaires have been tested for validity and reliability, and classical assumption tests have been carried out and all of them are eligible to continue analysis with path analysis. The result is that physical training and shuttlecock hitting practice have a significant and positive effect on smash power in badminton both partially and simultaneously.
Bleeding metastasis of renal cell cancer to anal canal treated with radiation
Authors: Ulusoy Cemal , Mete Sila Guclu , Nikolovski Andrej
Published: September 2023

Renal cell cancer (RCC) has the ability to metastasize to various organs, including the anal canal which is reported to be the rarest location. An 88-year-old male patient who had previously been treated for right RCC subsequently developed distant metastases to the prostate, lungs, and small bowel. Four years following nephrectomy, the patient presented with a bleeding anal mass which was excised and has been proven to be an anal canal metastasis of RCC. Eight months post excision, regrowth occurred. The patient underwent stereotactic ablative body radiotherapy resulting in satisfactory regression during the 2-month follow-up period, without episodes of bleeding. The treatment options for metastatic post-nephrectomy disease should be considered with a multidisciplinary approach in order to achieve satisfactory symptom relief.
New records of moth flies (Diptera, Psychodidae) for the Dutch Fauna
Authors: Jaume-Schinkel Santiago , Kvifte Gunnar , Njunjić Iva , Schilthuizen Menno
Published: September 2023

Prior to this study, the moth flies in The Netherlands were represented by 61 species. Our findings derive from a citizen-science expedition in the Vondelpark in Amsterdam, one of the oldest public parks and best known parks in The Netherlands. The combination of citizen science and the exploration of a well-known urban park has allowed us to contribute to the knowledge of moth fly species present in The Netherlands. The findings from this study provide valuable insights into the distribution, taxonomy and genetic resources ofPsychodaandPanimerusspecies, enhancing our understanding of insect biodiversity and promoting future research in this field.

Our study provides two new geographical records of the moth flies in The Netherlands, namely,Psychoda uniformataHaseman, 1907 andPanimerus maynei(Tonnoir, 1920) elevating the total number of species to 63. Furthermore, we provide re-descriptions of the females ofPanimerus notabilis(Eaton, 1893) andP. goetghebueri(Tonnoir, 1919). Additionally, we make available for the first time, the sequence of the 5’-end of the cytochrome c oxidase subunit I (COI) gene orCOIBarcodes forPanimerus notabilis,P. goetghebueriandP. maynei. TheseCOIBarcodes serve as valuable tools for future species identification within the genus.
Antiproliferative activity of ruthenium complex II against human cancer cell in vitro
Authors: Saadh Mohamed
Published: September 2023

Despite significant advancements in cancer treatment, there is a constant need for new and effective therapeutic options. One such potential weapon in the fight against cancer is ruthenium complex II. In this article, we synthesized, characterized, and studied the activity of dithiocyanato-N-bis[8-(diphenylphosphino)quinoline]ruthenium (II) [Ru(N-P)2(NCS)2] against MCF-7 human adenocarcinoma cells and the MRC-5 cell lines from fetal lung fibroblast-like cells as normal cells, as well as the mechanisms of action and selectivity. This study demonstrated that [Ru(N-P)2(NCS)2] has cytotoxic activity against MCF-7 with IC50 values of 7.56 µg/ml and cytotoxic activity against MRC-5 cell lines with IC50 values of 576.6 µg/ml. [Ru(N-P)2(NCS)2] showed more selective cytotoxic activity against MCF-7 cancer cell lines than MRC-5 normal cell lines. . This study demonstrated the potent apoptotic activity of ruthenium complex II by determining the activation of caspase-3, highlighting its potential as a therapeutic agent in cancer treatment. The [Ru(N-P)2(NCS)2] is considered promising for researchers investigating putative biological activities, particularly antitumor and immune-related activity.
A new species of Iochroma Benth. (Solanaceae) from the eastern Andes of Colombia
Authors: Orejuela Andrés , Smith Stacey D. , Villanueva Boris , Deanna Rocío
Published: September 2023

Iochroma orozcoae A.Orejuela & S.D.Sm., sp. nov. (Solanaceae) is described from the Andean forests of Cundinamarca in the eastern cordillera of Colombia. Iochroma orozcoae was first collected by the eminent Spanish priest and botanist José Celestino Mutis in the late part of the 18th century, but the specimens have lain unrecognised in herbaria for over 200 years. The species shares many features with its closest relative, Iochroma baumii S.D.Sm. & S.Leiva, but it differs from it in having small flowers with five corolla lobes and few inflorescences per branch, located near the shoot apex with 1 to 4 (–8) flowers, fruits that are greenish-yellow when ripe and its restricted geographic distribution. A description of I. orozcoae is provided, along with a detailed illustration, photographs of live plants, a comparison with closely-related species and a key to all Colombian species of Iochroma Benth. In closing, we emphasise the value of historical collections for the knowledge of biodiversity.
Pandemic Grief and Complications in Bereavement: From Research Evidence to Clinical Relevance
Authors: Neimeyer Robert A. , Breen Lauren J. , Lee Sherman A.
Published: September 2023

En raison de l’inquiétude générale suscitée par l’impact psychologique de la perte d’un proche victime du COVID-19, nous appliquons notre programme de recherche à multiples facettes sur cette cohorte vulnérable de personnes confrontées au deuil au cours de la pandémie. Nous commençons par un résumé de la construction et de la validation de la Pandemic Grief Scale, une mesure brève et fiable en cinq points des symptômes et des difficultés cliniquement significatifs au lendemain d’une telle perte. Nous poursuivons ensuite la revue d’une série d’études qui documentent l’impact sévère du deuil pandémique. Nous identifions dix facteurs de risque fondés sur des preuves et distincts de la perte dans le contexte des restrictions liées au coronavirus. Nous démontrons le fardeau des problèmes relationnels non résolus avec la personne décédée qui en résulte, et rapportons l’élaboration du premier outil de dépistage validé pour les niveaux cliniques de déficience fonctionnelle due au deuil. Nous concluons par les implications pratiques de cette recherche dans le contexte de la pratique clinique, allant du dépistage le plus large de l’impact psychologique délétère du deuil actuel à des questions spécifiques méritant une attention particulière dans la thérapie du deuil.
La Turquie et l’Union européenne
Authors: Drevet Jean-François
Published: September 2023

En dépit d’une politique contestable et contestée dans bien des domaines (à commencer par l’économie), le président Recep Tayyip Erdoğan a été réélu à la tête de la Turquie, fin mai 2023, pour un troisième mandat. Bien des dirigeants européens souhaitaient sans doute un changement, nourrissant l’espoir de voir se détendre les relations entre Ankara et l’Union européenne, voire l’Alliance atlantique. Mais le peuple turc en a décidé autrement ; il va donc falloir s’en accommoder. Dans ce contexte, Jean-François Drevet fait ici le point sur la nature et l’état actuel des relations entre la Turquie — pays pivot entre l’Europe, l’Asie, la Russie et le Moyen-Orient —, l’Union européenne et les États-Unis — de nouveau incontournables pour la défense européenne au travers de l’OTAN. Il revient tout d’abord sur les postures d’Ankara en matière économique et sur son jeu diplomatique, en particulier avec Moscou. Il pointe ensuite les évolutions qui se font jour dans la façon dont Washington et Bruxelles appréhendent la Turquie sur la scène internationale, soulignant que celle-ci n’est « plus aussi indispensable » qu’on le croit. Il précise enfin les éléments qui pourraient conduire à une nouvelle grammaire dans les relations entre Ankara, Bruxelles et Washington, favorisant une forme d’apaisement ; mais pour ce faire, les Occidentaux devront convaincre Recep Erdoğan de « renoncer au néo-ottomanisme » qui l’anime et sans doute afficher une plus grande fermeté à son égard. S.D.
Conclusions et ouverture : dialogue intergénérationnel
Authors: Glinel Marie
Published: September 2023

Alors que la loi bioéthique vient d’être votée, différents acteurs lors de ce colloque ont cherché à étudier sous leurs angles respectifs le changement de paradigme opéré par cette loi, résolument très libérale. A travers une grille de lecture héritée des ordres de Pascal, les différents niveaux de discours moral, politique, juridique et scientifique servent de référence à l’évaluation d’un discours souvent très contrasté. L’évolution du paradigme de la loi bioéthique, à la loi zoéthique, en quête de légitimité sociale et de réponse aux désirs individuels, marque un tournant dans les révisions des lois de bioéthique. Dans ces conditions, la loi bioéthique ne perd-elle pas sa raison d’être, universelle ?
Recent evolutions in digital European copyright law
Authors: Synodinou Tatiana-Eleni
Published: September 2023

L’objectif de cet article est de présenter de manière critique les évolutions récentes dans le domaine du droit d’auteur européen. Il est divisé en quatre parties. La première partie porte sur l’application du droit d’auteur à la fourniture de liens Internet. La deuxième partie analyse l’émergence de la liberté d’expression comme possible limite externe du droit d’auteur. La troisième partie traite de la manière dont les principes du droit d’auteur de l’UE pourraient répondre aux défis posés par l’intelligence artificielle (IA). Enfin, la quatrième partie considère le droit d’auteur comme un domaine expérimental du droit de l’Internet et est consacrée aux évolutions spécifiques au domaine du droit d’auteur numérique et à la question de savoir si ces évolutions pourraient influer de manière plus générale sur la réglementation de l’Internet par l’UE.
Les secrets d’affaires : transposition en droit luxembourgeois de la directive européenne 2016/943
Authors: Saettel Camille
Published: September 2023

La directive européenne 2016/943 du 8 juin 2016 sur la protection des secrets des affaires, fraîchement transposée en droit luxembourgeois à travers la loi du 26 juin 2019, est venue donner un souffle nouveau à un concept souffrant d’un certain déficit de popularité, compte tenu de régimes de protection peu cohérents voire inadaptés au sein des différents États membres. La directive européenne, à présent transposée dans les ordres juridiques nationaux, vient renforcer le régime de protection du patrimoine informationnel des sociétés, offrant aux entreprises, à côté des droits de propriété intellectuelle classiques, un nouvel outil de protection de leurs informations commerciales et de leur savoir-faire. Le présent article se propose d’étudier en détail ce nouveau régime de protection.
Le projet de loi n° 7479 relatif à l’organisation de l’Autorité nationale de concurrence : vers une plus grande indépendance et efficacité ?
Authors: Bleser Gabriel
Published: September 2023

The bill n° 7479 on the organisation of the National Competition Authority and repealing the competition law of 23 October 2011 was tabled in order to transpose into national law the Directive (EU) 2019/1. If this bill is adopted, several substantial advances will be introduced although some limits will remain.
“Intellectual property” and “licence”: what does it mean in European authors’ rights language?
Authors: Mohr Pablo J.
Published: September 2023

Cet article analyse les notions de « propriété intellectuelle » et « licence » en droits d’auteur. Il met en relief le fait que, malgré l’utilisation des mêmes mots dans différents contextes et différents systèmes juridiques, leur signification n’est pas la même. Les cinq systèmes juridiques nationaux considérés sont le droit français, le droit anglais, le droit allemand, le droit espagnol et le droit luxembourgeois.
L’intermédiation aux frontières du droit
Authors: Vigneron Jeoffrey
Published: September 2023

Le droit des plateforme en plein essor – Il s’agit à proprement parler d’une synthèse de dispositions internationales récentes qui viennent compléter un arsenal juridique « classique » se transposant souvent avec difficultés à l’univers numérique. Même si le terme « plateforme » est largement utilisé lorsqu’il se réfère sans distinction aux marchés ou aux réseaux sociaux, il n’y a pas de consensus sur sa définition exacte. Cependant, la réalité est en train de rattraper et même de dépasser les écrits académiques sur ce sujet. Des affaires récentes, tant au niveau européen que national, ont également révélé la nécessité d’une réglementation dans ce domaine afin d’assurer la sécurité juridique. Cet article traite de la définition de ce qu’est une plateforme et des règles qui lui sont applicables dans le cadre de certaines de leurs relations avec leurs utilisateurs.