bluuebunny/crossref_metadata_2025 huggingface dataset:
Population Bursts in a Modular Neural Network as a Mechanism for Synchronized Activity in KNDy Neurons
Authors: Blanco Wilfredo , Tabak Joel , Bertram Richard
Published: January 2024

The pulsatile activity of gonadotropin-releasing hormone neurons (GnRH neurons) is a key factor in the regulation of reproductive hormones. This pulsatility is orchestrated by a network of neurons that release the neurotransmitters kisspeptin, neurokinin B, and dynorphin (KNDy neurons), and produce episodic bursts of activity driving the GnRH neurons. We show in this computational study that the features of coordinated KNDy neuron activity can be explained by a neural network in which connectivity among neurons is modular. That is, a network structure consisting of clusters of highly-connected neurons with sparse coupling among the clusters. This modular structure, with distinct parameters for intracluster and intercluster coupling, also yields predictions for the differential effects of the co-released transmitters neurokinin B and dynorphin. In particular, it provides one possible explanation for how the excitatory neurotransmitter neurokinin B and the inhibitory neurotransmitter dynorphin can both increase the degree of synchronization among KNDy neurons.

Author summary

Since the discovery of a small population of hypothalamic neurons that secrete kisspeptin, neurokinin B, and dynorphin (KNDy neurons), there has been interest in their role as a pacemaker for the pulsatile release of key reproductive hormones. A fundamental question is what mechanism coordinates KNDy neuron activity to generate population bursts. Optical imaging of the KNDy network at single-neuron resolution has revealed that individual KNDy neurons participate in many, but not all, population bursts. It has also shown that the order in which the neurons are recruited in each burst could be highly determined in some animals but not in others. We demonstrate here that these observations can be explained by a neural network with a modular structure. We also show how such a structure can explain the paradoxical finding that both the excitatory neurotransmitter neurokinin B and the inhibitory neurotransmitter dynorphin can act to increase the degree of synchronization among the KNDy neurons.
Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission
Authors: Dill Holger , Liewald Jana F. , Becker Michelle , Seidenthal Marius , Gottschalk Alexander
Published: January 2024

The regulation of synaptic transmission is crucial for plasticity, homeostasis and learning. Chemical synaptic transmission is thus modulated to accommodate different activity levels, which also enables homeostatic scaling in pre- and postsynaptic compartments. In nematodes, cAMP signaling enhances cholinergic neuron output, and these neurons use neuropeptide signaling to modulate synaptic vesicle content. To explore if this mechanism is conserved in vertebrates, we studied the involvement of neuropeptides in cholinergic transmission at the neuromuscular junction of larval zebrafish. Optogenetic stimulation by photoactivated adenylyl cyclase (bPAC) resulted in elevated locomotion as measured in behavioural assays. Furthermore, post-synaptic patch-clamp recordings revealed that in bPAC transgenics, the frequency of miniature excitatory postsynaptic currents (mEPSCs) was increased after photostimulation. These results suggested that cAMP-mediated activation of ZF motor neurons leads to increased fusion of SVs, consequently resulting in enhanced neuromuscular activity. We generated mutants lacking the neuropeptide processing enzyme carboxypeptidase E (cpe), and the most abundant neuropeptide precursor in motor neurons, tachykinin (tac1). Both mutants showed exaggerated locomotion after photostimulation.cpemutants exhibit lower mEPSC frequency during photostimulation and less large-amplitude mEPSCs. Intac1mutants mEPSC frequency was not affected but amplitudes were significantly smaller. Exaggerated locomotion in the mutants thus reflected upscaling of postsynaptic excitability.cpeandtac1mutant muscles expressed more nicotinic acetylcholine receptors (nAChR) on their surface. Thus, neuropeptide signaling regulates synaptic transmitter output in zebrafish motor neurons, and muscle cells homeostatically regulate nAChR surface expression, compensating reduced presynaptic input. This mechanism may be widely conserved in the animal kingdom.
A removable and cosmopolitan dsRNA Toti-like virus causes latent infection in a model diatom strain
Authors: Zhang Jiahuan , Li Chenjie , Xiong Xiaofeng , Guo Kangning , Feng Yanlei , Zhang Huan , Hu Hanhua , Li Xiaobo
Published: January 2024

Diatoms contribute to 20% of global primary productivity. Although some diatom viruses have been identified, the molecular mechanisms underlying their interactions with the host remain poorly understood. In this study, we report the discovery of an RNA molecule in the DNA extracts of thePhaeodactylum tricornutumstrain Pt1, which possesses a well-annotated genome and has been used as a diatom model system since 1956. We confirmed this molecule to be a double-stranded linear RNA molecule and, through sequencing, demonstrated it to be a virus in theTotiviridaefamily that is prevalent among marine stramenopiles. We also detected this virus inPhaeodactylum tricornutumstrain Pt3, which was collected in 1930s from a similar geographic location to Pt1, suggesting its prevalence within the region. By employing various inhibitors of the viral RNA-dependent RNA polymerase, we successfully generated a virus-free line isogenic to Pt1, establishing a model system to investigate the impact of RNA viruses on diatom physiology. The virus-free lines did not display obvious growth advantages or defects, indicating a tendency of the virus towards latent infection. Furthermore, we generated a robust antibody against the coat protein of this virus. By performing immunoprecipitation coupled with mass spectrometry, we found that translation-related proteins are enriched as potential interacting partners of the coat protein. Our results suggest that potential viral impacts in molecular research should be considered when Pt1 and Pt3 are used for studying translation-related processes. Additionally, our study unveiled a temperate mode of interaction between viruses and marine algal hosts that differs from the commonly-reported virulent, lytic infections.

Highlights

prevalent dsRNA virus belonging to theTotiviridaefamily was discovered in the Pt1 and Pt3 strains of the model diatomPhaeodactylum tricornutum.

virus is absent in eight other strains ofP. tricornutum, highlighting the importance of studying multiple accessions.

virus can be eliminated using a nucleotide analogue, resulting in a virus-free isogenic strain that allows us to investigate how viruses may affect diatom physiology.

robust antibody against the coat protein of this virus was developed to assist mechanistic studies of diatom-virus interactions.
Notch Inhibition Enhances Morphological Reprogramming of microRNA-Induced Human Neurons
Authors: Burbach Kyle F. , Yoo Andrew S.
Published: January 2024

Although the importance of Notch signaling in brain development is well-known, its specific contribution to cellular reprogramming remains less defined. Here, we use microRNA-induced neurons that are directly reprogrammed from human fibroblasts to determine how Notch signaling contributes to neuronal identity. We found that inhibiting Notch signaling led to an increase in neurite extension, while activating Notch signaling had the opposite effect. Surprisingly, Notch inhibition during the first week of reprogramming was both necessary and sufficient to enhance neurite outgrowth at a later timepoint. This timeframe is when the reprogramming miRNAs, miR-9/9* and miR-124, primarily induce a post-mitotic state and erase fibroblast identity. Accordingly, transcriptomic analysis showed that the effect of Notch inhibition was likely due to improvements in fibroblast fate erasure and silencing of anti-neuronal genes. To this effect, we identifyMYLIP, whose downregulation in response to Notch inhibition significantly promoted neurite outgrowth. Moreover, Notch inhibition resulted in cells with neuronal transcriptome signature defined by expressing long genes at a faster rate than the control, demonstrating the effect of accelerated fate erasure on neuronal fate acquisition. Our results demonstrate the critical role of Notch signaling in mediating morphological changes in miRNA-based neuronal reprogramming of human adult fibroblasts.
Interneuron-like features of microglia in the mouse outer retina
Authors: Toros Sara , Kane Thomas , Hare Aura , Abbar Hassina , Madoo Akshay , De Rossi Giulia , Powell Kate , Rizzi Matteo
Published: January 2024

Microglia have recently been associated with complex functionalities both in the brain and the retina, including in synaptic function and plasticity. While investigating the morphology, protein expression profile and connectivity of microglia in the mouse outer retina, we have found that they closely resemble interneurons in the outer retina of other species. We argue that functional studies are needed to reveal whether they also perform an interneuron-like role in vision.
D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability
Authors: Rona Gergely , Miwatani-Minter Bearach , Zhang Qingyue , Goldberg Hailey V. , Kerzhnerman Marc A. , Howard Jesse B. , Simoneschi Daniele , Lane Ethan , Hobbs John W. , Sassani Elizabeth , Wang Andrew A. , Keegan Sarah , Laverty Daniel J. , Piett Cortt G. , Pongor Lorinc S. , Xu Miranda Li , Andrade Joshua , Thomas Anish , Sicinski Piotr , Askenazi Manor , Ueberheide Beatrix , Fenyö David , Nagel Zachary D. , Pagano Michele
Published: January 2024

The large majority of oxidative DNA lesions occurring in the G1 phase of the cell cycle are repaired by base excision repair (BER) rather than mismatch repair (MMR) to avoid long resections that can lead to genomic instability and cell death. However, the molecular mechanisms dictating pathway choice between MMR and BER have remained unknown. Here, we show that, during G1, D-type cyclins are recruited to sites of oxidative DNA damage in a PCNA- and p21-dependent manner. D-type cyclins shield p21 from its two ubiquitin ligases CRL1SKP2and CRL4CDT2in a CDK4/6-independent manner. In turn, p21 competes through its PCNA-interacting protein degron with MMR components for their binding to PCNA. This inhibits MMR while not affecting BER. At the G1/S transition, the CRL4AMBRA1-dependent degradation of D-type cyclins renders p21 susceptible to proteolysis. These timely degradation events allow the proper binding of MMR proteins to PCNA, enabling the repair of DNA replication errors. Persistent expression of cyclin D1 during S-phase increases the mutational burden and promotes microsatellite instability. Thus, the expression of D-type cyclins inhibits MMR in G1, whereas their degradation is necessary for proper MMR function in S.

One-Sentence Summary

To maintain genome stability, D-type cyclins limit mismatch repair (MMR) in G1, whereas their degradation is necessary for proper MMR function in S phase.
Environmental and molecular control of tissue-specific ionocyte differentiation in zebrafish
Authors: Peloggia Julia , Lush Mark E. , Tsai Ya-Yin , Wood Christopher , Piotrowski Tatjana
Published: January 2024

Organisms adjust their physiology to cope with environmental fluctuations and maintain fitness. These adaptations occur via genetic changes over multiple generations or through acclimation, a set of reversible phenotypic changes that confer resilience to the individual. Aquatic organisms are subject to dramatic seasonal fluctuations in water salinity, which can affect the function of lateral line mechanosensory hair cells. To maintain hair cell function when salinity decreases, ion-regulating cells, Neuromast-associated ionocytes (Nm ionocytes), increase in number and invade lateral line neuromasts. How environmental changes trigger this adaptive differentiation of Nm ionocytes and how these cells are specified is still unknown. Here, we identify Nm ionocyte progenitors asfoxi3a/foxi3b-expressing skin cells and show that their differentiation is associated with sequential activation of different Notch pathway components, which control ionocyte survival. We demonstrate that new Nm ionocytes are rapidly specified by absolute salinity levels, independently of stress response pathways. We further show that Nm ionocyte differentiation is selectively triggered by depletion of specific ions, such as Ca2+and Na+/Cl−, but not by low K+levels, and is independent of media osmolarity. Finally, we demonstrate that hair cell activity plays a role in Nm ionocyte recruitment and that systemic factors are not necessary for Nm ionocyte induction. In summary, we have identified how environmental changes activate a signaling cascade that triggers basal skin cell progenitors to differentiate into Nm ionocytes and invade lateral line organs. This adaptive behavior is an example of physiological plasticity that may prove essential for survival in changing climates.
Ultra-sensitive molecular residual disease detection through whole genome sequencing with single-read error correction
Authors: Li Xinxing , Liu Tao , Bacchiocchi Antonella , Li Mengxing , Cheng Wen , Wittkop Tobias , Mendez Fernando , Wang Yingyu , Tang Paul , Yao Qianqian , Bosenberg Marcus W. , Sznol Mario , Yan Qin , Faham Malek , Weng Li , Halaban Ruth , Jin Hai , Hu Zhiqian
Published: January 2024

While whole genome sequencing (WGS) of cell-free DNA (cfDNA) holds enormous promise for molecular residual disease (MRD) detection, its performance is limited by WGS error rate. Here we introduce AccuScan, an efficient cfDNA WGS technology that enables genome-wide error correction at single read level, achieving an error rate of 4.2×10-7, which is about two orders of magnitude lower than a read-centric de-noising method. When applied to MRD detection, AccuScan demonstrated analytical sensitivity down to 10-6circulating tumor allele fraction at 99% sample level specificity. In colorectal cancer, AccuScan showed 90% landmark sensitivity for predicting relapse. It also showed robust MRD performance with esophageal cancer using samples collected as early as 1 week after surgery, and predictive value for immunotherapy monitoring with melanoma patients. Overall, AccuScan provides a highly accurate WGS solution for MRD, empowering circulating tumor DNA detection at parts per million range without high sample input nor personalized reagents.

One Sentence Summary

AccuScan showed remarkable ultra-low limit of detection with a short turnaround time, low sample requirement and a simple workflow for MRD detection.
Consumer attitude and behavioural intention towards organic wine: the roles of consumer values and involvement
Authors: Dong Yingying , Gao Lisa
Published: January 2024

Purpose

This study aims to identify the decision-making process involved in the purchase of organic wine from consumer values to attitudes to behavioural intention towards organic wine via the value–attitude–behaviour (VAB) model. Involvement in wine is also taken into consideration.

Design/methodology/approach

The data were collected using a snowball sampling method and a closed-ended questionnaire. A total of 209 responses were analysed. Linear regression and PROCESS Macro on SPSS were used to perform data analysis.

Findings

Both biospheric-altruistic values and egoistic values are positively associated with attitudes towards organic wine. Attitude is found to mediate the relationship between biospheric-altruistic/egoistic values and behavioural intention. Egoistic values are found to significantly predict behavioural intention in the organic wine purchase context. Involvement was found to moderate the relationship between egoistic values and attitudinal loyalty.

Originality/value

This study identifies the decision-making hierarchy from consumer values to attitudes to behavioural intention, theoretically confirming the robustness of the VAB model in the organic wine consumption context. It also makes a practical contribution by indicating the marketing emphasis of organic wine and segmenting potential consumers according to their values and levels of wine involvement.
Who is the next China? Comparative advantage analysis from top ten apparel exporting nations
Authors: Das Sudipta , Hasan Md Rokibul , Das Debanjan
Published: January 2024

Purpose

This study aims to measure the competitiveness of top apparel exporting nations competing with China in different apparel product categories across the global environment.

Design/methodology/approach

Compound annual growth rate, trade competitiveness, market share percentages, revealed comparative advantage and its variant normalized revealed comparative advantage using two-, four- and six-digit harmonized system codes for the period of 2016–2021 were used to understand the comparative advantage of competing apparel exporting nations.

Findings

The findings revealed that China still holds a more decisive comparative advantage than its competitors over the majority of the product categories within the knitted or not knitted apparel and clothing accessories. The other competing nations hold better export competitiveness over China in specific categories. However, that is not sufficient to be the “Next China.”

Research limitations/implications

The study has important implications for different stakeholders of the global apparel industry, such as governments, industry officials, policymakers, investors, researchers and students. The study’s limitations arise from using product categories as competitiveness indicators, notably relying on a macro level approach for measurement while the micro level perspective is not analyzed, which constitutes a significant limitation of the study.

Originality/value

This research thoroughly analyzes the competitive position of the top ten apparel-exporting countries in the global market.
How customer knowledge management helps retain fitness club members: a mediating effect of relationship quality
Authors: Ng Kenneth Shiu Pong , Feng Yan , Lai Ivan Ka Wai , Yang Lois Zi-Yu
Published: January 2024

Purpose

This study aims to develop a conceptual model to understand how customer knowledge management (CKM) affects fitness club membership renewal through the mediation of relationship quality.

Design/methodology/approach

Data were collected outside of fitness clubs using a systematic sampling method. A total of 224 valid responses were collected. Structural equation modelling was used to evaluate the relationship between the constructs of the research model.

Findings

The results indicate that both knowledge from customers and knowledge for customers have a positive influence on customer satisfaction and customer trust. Among them, knowledge for customers has a stronger influence on customer satisfaction while knowledge from customers has a greater influence on customer trust. Additionally, three dimensions of relationship quality (customer satisfaction, customer trust and customer commitment) positively influence membership renewal intention with customer commitment exhibiting the greatest influence on it.

Originality/value

This study combines the theories of CKM and relationship quality management to explain why members will renew their service contracts. By using fitness clubs as an example, this research extends the authors' understanding of how knowledge from and for customers can influence customers' attitudes and behavioural intentions towards service companies.
DeFi era: the behavioral intentions toward cryptocurrency in Lebanon
Authors: Abou Ali Ali Abdel Karim
Published: January 2024

Purpose

This paper examines the factors which impact the behavioral intentions toward cryptocurrency based on signaling theory.

Design/methodology/approach

Data were collected through online questionnaire, and responses from 223 individuals in Lebanon were analyzed through SEM technique using Amos 24.

Findings

The outcomes portrayed the positive effect of perceived benefits and trust in cryptocurrency on behavioral intentions toward cryptocurrency; while not supporting the hypothesized influence of herd behavior and regulatory support.

Originality/value

This paper is among the first studies to adopt Signaling Theory (ST) in the cryptocurrency behavioral intentions research. Moreover, it is of the initial efforts in Lebanon and Middle East in evaluating behavioral intentions to use cryptocurrency, and it provide insights for future researchers, crypto project owners, crypto investors and crypto trading platforms.
Online privacy literacy and users' information privacy empowerment: the case of GDPR in Europe
Authors: Prince Christine , Omrani Nessrine , Schiavone Francesco
Published: January 2024

Purpose

Research on online user privacy shows that empirical evidence on how privacy literacy relates to users' information privacy empowerment is missing. To fill this gap, this paper investigated the respective influence of two primary dimensions of online privacy literacy – namely declarative and procedural knowledge – on online users' information privacy empowerment.

Design/methodology/approach

An empirical analysis is conducted using a dataset collected in Europe. This survey was conducted in 2019 among 27,524 representative respondents of the European population.

Findings

The main results show that users' procedural knowledge is positively linked to users' privacy empowerment. The relationship between users' declarative knowledge and users' privacy empowerment is partially supported. While greater awareness about firms and organizations practices in terms of data collections and further uses conditions was found to be significantly associated with increased users' privacy empowerment, unpredictably, results revealed that the awareness about the GDPR and user’s privacy empowerment are negatively associated. The empirical findings reveal also that greater online privacy literacy is associated with heightened users' information privacy empowerment.

Originality/value

While few advanced studies made systematic efforts to measure changes occurred on websites since the GDPR enforcement, it remains unclear, however, how individuals perceive, understand and apply the GDPR rights/guarantees and their likelihood to strengthen users' information privacy control. Therefore, this paper contributes empirically to understanding how online users' privacy literacy shaped by both users' declarative and procedural knowledge is likely to affect users' information privacy empowerment. The study empirically investigates the effectiveness of the GDPR in raising users' information privacy empowerment from user-based perspective. Results stress the importance of greater transparency of data tracking and processing decisions made by online businesses and services to strengthen users' control over information privacy. Study findings also put emphasis on the crucial need for more educational efforts to raise users' awareness about the GDPR rights/guarantees related to data protection. Empirical findings also show that users who are more likely to adopt self-protective approaches to reinforce personal data privacy are more likely to perceive greater control over personal data. A broad implication of this finding for practitioners and E-businesses stresses the need for empowering users with adequate privacy protection tools to ensure more confidential transactions.
Inflation–inequality puzzle: is it still apparent?
Authors: Berisha Edmond , Gupta Rangan , Gharehgozli Orkideh
Published: January 2024

Purpose

The primary focus of this study is to examine the distributional consequences of the widespread increase in prices. The fundamental question the study aims to address is whether the dynamics of income distribution due to higher inflation differ in the short term compared to the long run.

Design/methodology/approach

The authors estimated a panel-data model (fixed effects) using inequality and inflation data available at a high frequency, i.e. on a quarterly basis for over 30 years, and found evidence that inflation causes rapid swings in income distribution.

Findings

The authors’ contribution to the literature lies in providing evidence that inflation rapidly causes swings in income distribution, even after controlling for the state of the economy. The authors also demonstrate that the magnitude and direction of the effect of inflation on income inequality depend on whether the initial inflation rate is below or above the Federal Reserve’s target of 2%.

Originality/value

To the best of the authors’ knowledge, the authors are the first to emphasize that the targets set by central banks can drive the strength and direction of the relationship between inflation and income inequality.
Research on the evolution and determinants of knowledge transfer network in patent-intensive industries
Authors: Li Jianguo , Gong Yuwen , Li Hong
Published: January 2024

Purpose

This study aims to investigate the structural characteristics, spatial evolution paths and internal driving mechanisms of the knowledge transfer (KT) network in China’s patent-intensive industries (PIIs). The authors' goal is to provide valuable insights to inform policy-making that fosters the development of relevant industries. The authors also aim to offer a fresh perspective for future spatiotemporal studies on industrial KT and innovation networks.

Design/methodology/approach

In this study, the authors analyze the patent transfer (PT) data of listed companies in China’s information and communication technology (ICT) industry, spanning from 2010 to 2021. The authors use social network analysis and the quadratic assignment procedure (QAP) method to explore the problem of China’s PIIs KT from the perspectives of technical characteristics evolution, network and spatial evolution and internal driving mechanisms.

Findings

The results indicate that the knowledge fields involved in the PT of China’s ICT industry primarily focus on digital information transmission technology. From 2010 to 2021, the scale of the ICT industry’s KT network expanded rapidly. However, the polarization of industrial knowledge distribution is becoming more serious. QAP regression analysis shows that economic proximity and geographical proximity do not affect KT activities. The similarity of knowledge application capacity, innovation capacity and technology demand categories in various regions has a certain degree of impact on KT in the ICT industry.

Originality/value

The current research on PIIs mainly focuses on measuring economic contributions and innovation efficiency, but less on KT in PIIs. This study explores KT in PIIs from the perspectives of technological characteristics, network and spatial evolution. The authors propose a theoretical framework to understand the internal driving mechanisms of industrial KT networks.
Online bubbles and echo chambers as social systems
Authors: Palmieri Emerson
Published: January 2024

Purpose

The aim of the text is to reflect on the formation of the so-called digital echo chambers or filter bubbles, which are environments formed around particular topics whose objective is to promote a given political-ideological position. The argument the author puts forward is that echo chambers are social systems of interaction created to deal with the process of informational overload brought about by the consolidation of digital media in people’s daily lives.

Design/methodology/approach

The author used Niklas Luhmann’s theory of social systems to explain what the author is calling social systems of interaction. Furthermore, the author made clarifications about: (1) the current debate regarding echo chambers; (2) what is the concept of “information” that the author is using to formulate the proposition and (3) what is the specificity that digital media bring when the author talks about informational overload and about the formation of echo chambers.

Findings

The author concluded that echo chambers can be seen as digital interaction systems, but the concept of “interaction” must be adapted. The author also concluded that echo chambers help society to deal with the phenomenon of informational overload.

Originality/value

There are few works which try to make a detailed analysis of echo chambers from a Luhmannian perspective. With the propositions presented in this text, along with other writings of the own, the author gives an important step in that direction by introducing the topic in the social systems researchers community.
The role of technology in entrepreneurship: a comprehensive systematic and bibliometric analysis
Authors: Jayanna Usha Rani , Jaya Prakash Senthil Kumar , Aluvala Ravi , Venkata Rao B.
Published: January 2024

Purpose

Through bibliometric analysis, the study intends to reveal the evolution of the trends in the Scopus database, the scope of research and the connection between technology and entrepreneurship.

Design/methodology/approach

This study uses a comprehensive science mapping approach, integrating network visualisation to map research groups, bibliometric analysis to measure publication trends and thematic analysis to identify overarching themes. This study uses a thorough technique to examine the complex interaction between technology and entrepreneurship from 2000 to 2023. The collection includes information from various sources, creating a corpus of 2,207 documents. These sources include 698 scholarly journals, books and other publications.

Findings

According to the report, the interest in technology and entrepreneurship is expanding. The three nations conducting the most study on this subject is the USA, the UK and Italy. Some of the top writers in this area include James A. Cunningham, Alison N. Link and David B. Audretsch.

Research limitations/implications

The study found possibilities and problems associated with the interaction between technology and entrepreneurship. Additionally, the study found several research holes in this area. The study also noted some research gaps in this field, including those related to the sustainability of society and the environment, the effects of entrepreneurship on inequality and the difficulties faced by entrepreneurs in underdeveloped nations.

Practical implications

This study thoroughly overviews the business and technology sectors. It outlines some of the difficulties that must be overcome whilst identifying the main research trends in this field. Researchers, decision-makers and businesspeople interested in using technology for entrepreneurial endeavours can all benefit from the study’s findings.

Social implications

This study’s dataset’s scope, which might not include all pertinent publications, is one of its limitations. Nevertheless, the results add to a thorough picture of the state of the profession and recent developments. This study’s insights are valuable for researchers, policymakers and entrepreneurs interested in leveraging technology for entrepreneurial pursuits.

Originality/value

The research points to a number of directions that need more inquiry, such as in-depth studies into the social and environmental implications of technology-driven entrepreneurship and methods to combat inequality.
Urban planning education in the global south: exploring the possibilities for Egyptian curricula
Authors: Maged Ola Ahmed , Brown Robert , Abdel-Moneim Nancy
Published: January 2024

Purpose

The purpose of the research is to propose reforms that would help to bridge the gap between theory and practice and produce more effective urban planners. The research on urban planning curricula in the global South is a valuable contribution to the field of urban planning education. It provides a new perspective on the challenges facing urban planning education in these countries and offers a roadmap for improvement.

Design/methodology/approach

The research explores and evaluates the urban planning curricula in the global South, with a particular interest in Egypt. The research employs the use of questionnaires with 56 university instructors, analysed thematically, to evaluate the current content of curricula. The results are compared and correlated with a pilot study exploring research interest, government policies and practices of urban planning in Egypt.

Findings

Through comparing the results of the evaluation with the current research interest in urban planning in Egypt, the paper investigates the possibility of improving current educational curricula using comparative network analysis which would establish stronger interdisciplinary connections.

Originality/value

The seeming disconnects between urbanism concepts taught in educational curricula and their relevance in practice and reality is a vital issue in urban studies and planning. Interdisciplinary connections with topics like politics, economies, gender, and others can assist curricula in becoming more relevant to real-world situations. This disconnect is even more apparent in the global South where most educational content is highly derivative from Northern contexts. Though such interdisciplinary aspects are under discussed in educational curricula, they are frequently discussed in academic research.
Human intrusion detection for high-speed railway perimeter under all-weather condition
Authors: Guo Pengyue , Shi Tianyun , Ma Zhen , Wang Jing
Published: January 2024

Purpose

The paper aims to solve the problem of personnel intrusion identification within the limits of high-speed railways. It adopts the fusion method of millimeter wave radar and camera to improve the accuracy of object recognition in dark and harsh weather conditions.

Design/methodology/approach

This paper adopts the fusion strategy of radar and camera linkage to achieve focus amplification of long-distance targets and solves the problem of low illumination by laser light filling of the focus point. In order to improve the recognition effect, this paper adopts the YOLOv8 algorithm for multi-scale target recognition. In addition, for the image distortion caused by bad weather, this paper proposes a linkage and tracking fusion strategy to output the correct alarm results.

Findings

Simulated intrusion tests show that the proposed method can effectively detect human intrusion within 0–200 m during the day and night in sunny weather and can achieve more than 80% recognition accuracy for extreme severe weather conditions.

Originality/value

(1) The authors propose a personnel intrusion monitoring scheme based on the fusion of millimeter wave radar and camera, achieving all-weather intrusion monitoring; (2) The authors propose a new multi-level fusion algorithm based on linkage and tracking to achieve intrusion target monitoring under adverse weather conditions; (3) The authors have conducted a large number of innovative simulation experiments to verify the effectiveness of the method proposed in this article.
When young customers co-create value of AI-powered branded app: the mediating role of perceived authenticity
Authors: Vo Diem-Trang , Nguyen Long Thang Van , Dang-Pham Duy , Hoang Ai-Phuong
Published: January 2024

Purpose

Artificial intelligence (AI) allows the brand to co-create value with young customers through mobile apps. However, as many brands claim that their mobile apps are using the most updated AI technology, young customers face app fatigue and start questioning the authenticity of this touchpoint. This paper aims to study the mediating effect of authenticity for the value co-creation of AI-powered branded applications.

Design/methodology/approach

Drawing from regulatory engagement theory, this study conceptualize authenticity as the key construct in customers’ value experience process, which triggers customer value co-creation. Two scenario-based online experiments are conducted to collect data from 444 young customers. Data analysis is performed using ANOVA and Process Hayes.

Findings

The results reveal that perceived authenticity is an important mediator between media richness (chatbot vs AI text vs augmented reality) and value co-creation. There is no interaction effect of co-brand fit (high vs low) and source endorsement (doctor vs government) on the relationship between media richness and perceived authenticity, whereas injunctive norms (high vs low) strengthen this relationship.

Practical implications

The finding provides insights for marketing managers on engaging young customers suffering from app fatigue. Authenticity holds the key to young customers’ technological perceptions.

Originality/value

This research highlights the importance of perceived authenticity in encouraging young customers to co-create value. Young customers consider authenticity as a motivational force experience that involves customers through the app’s attributes (e.g. media richness) and social standards (e.g. norms), rather than brand factors (e.g. co-brand fit, source endorsement).
The combination of dermoscopy and reflectance confocal microscopy increases the diagnostic confidence of amelanotic/hypomelanotic lentigo maligna
Authors: Pizzichetta Maria Antonietta , Polesel Jerry , Perrot Jean Luc , Rubegni Pietro , Stanganelli Ignazio , Magi Serena , Mazzoni Laura , Farnetani Francesca , Pellacani Giovanni , Garutti Mattia , Puglisi Fabio , Cinotti Elisa ,   the Italian Melanoma Intergroup, Società Italiana di Dermatologia Chirurgica, Oncologica, Correttiva ed Estetica, and Groupe d'imagerie cutanée non invasive de la Société Française de Dermatologie
Published: January 2024

The dermoscopic diagnosis of amelanotic/hypomelanotic lentigo maligna/lentigo maligna melanoma (AHLM/LMM) may be very difficult in its early stages because of lack of pigment. Reflectance confocal microscopy (RCM) is an imaging technique that is especially helpful for the diagnosis of lentigo maligna. To determine the diagnostic performances of dermoscopy and RCM in the diagnosis of AHLM/LMMs we evaluated dermoscopic and RCM images of consecutive cases of histopathologically confirmed AHLM/LMMs, amelanotic/hypomelanotic basal cell carcinoma and squamous cell carcinoma (AHBCCs/AHSCCs), amelanotic/hypomelanotic benign lesions (AHBLs), and actinic keratoses (AKs) from five participating centers. Sensitivity, specificity, accuracy, predictive values, and level of diagnosis confidence were calculated for both diagnostic procedures. Both dermoscopy and RCM showed diagnostic performance >97% in the diagnosis of AHLM/LMMs versus AHBCC/AHSCCs and their combination slightly improved diagnostic performance, with accuracy increasing from 98.0% to 99.1%. Similarly, RCM in combination with dermoscopy showed a tiny increase in the diagnostic performance in the diagnosis of AHLM/LMMs versus AHBLs (accuracy increased from 87.2% to 88.8%) and versus AKs (accuracy increased from 91.4% to 93.4%). Although the increase in diagnostic performance due to RCM was modest, the combination of dermoscopy and RCM greatly increased the level of confidence; high confidence in the diagnosis of AHLM/LMMs versus AHBLs increased from 36.2% with dermoscopy alone to 76.6% with dermoscopy plus RMC. Based on our results, dermoscopy and RCM should be complementary to improve not only diagnostic accuracy but also the level of diagnostic certainty in the diagnosis of AHLM/LMMs.
Leaf‐level resistance to frost, drought and heat covaries across European temperate tree seedlings
Authors: Visakorpi Kristiina , Manzanedo Rubén D. , Görlich Anna Sofia , Schiendorfer Katja , Altermatt Bieger Annette , Gates Emily , Hille Ris Lambers Janneke
Published: January 2024

Most trees die as seedlings, with harsh environmental conditions, such as early‐spring frosts and summer heat waves, being important drivers of early mortality. However, it remains unclear whether tolerance to different environmental extremes (e.g. frost vs. heat) trades‐off, or covaries synergistically and how stress tolerances relate to growth rates and life history strategies. Given the likely role of extreme environmental conditions as environmental filters, the ability to tolerate different stressors at the seedling stage could shape the occurrence and composition of present and future forests.

We explored the relationships between different leaf‐level stress tolerances, functional traits and geographic distributions across 22 species of temperate European tree seedlings. We measured indicators of tolerance to frost, drought and heat and related these values to growth rates and to important functional traits (e.g. leaf mass per area and stem‐specific density). Finally, we explored the links between measured seedling stress tolerances and climatic niche limits inferred from adult trees' distributions.

We found that seedlings of most species were either moderately tolerant to all three stressors, or susceptible to all of them. Moreover, higher stress tolerances were associated with traits describing slower growth and lower competitive ability. However, seedling tolerances to climatic factors were unrelated to the environmental limits of their adult geographic distributions.

Synthesis. Our results suggest that temperate tree seedlings might not experience trade‐offs when facing an increase in multiple extreme climate stressors, but may experience trade‐offs related to growth rate and competitive ability in the establishment phase. The lack of correlation between leaf‐level stress tolerances and the environmental limits of adult geographic distributions suggests that predicting species' current or future geographic distributions in Europe will require a more nuanced understanding of how climatic tolerances at juvenile and adult stages influence range limits. A better understanding of the interaction between survival in extreme climate, leaf‐level stress tolerances of seedlings and the factors driving species distributions is needed to understand future forest responses to climate change.
An international study of diversity in occupational therapy research– A bibliographic review of English research literature
Authors: Mackenzie Lynette , Lexén Annika , Kaelin Vera C. , Hynes Patrick , Roosen Ina , Tam Elaine , Huang Lin‐Jye , Ye Ching‐Wei ,   World Federation of Occupational Therapists
Published: January 2024

Background

The cornerstone of a strong profession is the research that supports its knowledge base and practice. However, little is known about the range of international occupational therapy research.

Objective

To explore the range and diversity of the international occupational therapy research from published peer reviewed literature in English during the year 2018.

Methodology

Limited to 2018, a review was conducted of sources from i) health‐related search engines using search terms associated with occupational therapy practice, and ii) content pages of occupational therapy publications. Articles were excluded if they i) had no occupational therapy author, ii) were not peer reviewed, iii) not in English, and iv) did not include primary data collection (e.g., opinion pieces, position statements, study protocols). Of articles selected for analysis, data were extracted and synthesized according to the study's origin country, publishing research journal, the characteristics of the represented research, and its alignment with World Federation of Occupational Therapists research priorities.

Results

A total of 4,169 articles were retrieved from the search (i.e., 3,459 from health‐related search engines and 710 through a manual search of occupational therapy journals). After exclusions, 2,345 articles were included for analysis.

Conclusion

The review identified English published research was predominantly conducted in economically privileged countries. In addition, it revealed several research priorities that need further development such as evaluating the effectiveness of occupational therapy interventions.
The motility and chemosensory systems of Rhizobium leguminosarum, their role in symbiosis, and link to PTSNtr regulation
Authors: Aroney Samuel T. N. , Pini Francesco , Kessler Celia , Poole Philip S. , Sánchez‐Cañizares Carmen
Published: January 2024

Motility and chemotaxis are crucial processes for soil bacteria and plant–microbe interactions. This applies to the symbiotic bacterium Rhizobium leguminosarum, where motility is driven by flagella rotation controlled by two chemotaxis systems, Che1 and Che2. The Che1 cluster is particularly important in free‐living motility prior to the establishment of the symbiosis, with a che1 mutant delayed in nodulation and reduced in nodulation competitiveness. The Che2 system alters bacteroid development and nodule maturation. In this work, we also identified 27 putative chemoreceptors encoded in the R. leguminosarum bv. viciae 3841 genome and characterized its motility in different growth conditions. We describe a metabolism‐based taxis system in rhizobia that acts at high concentrations of dicarboxylates to halt motility independent of chemotaxis. Finally, we show how PTSNtr influences cell motility, with PTSNtr mutants exhibiting reduced swimming in different media. Motility is restored by the active forms of the PTSNtr output regulatory proteins, unphosphorylated ManX and phosphorylated PtsN. Overall, this work shows how rhizobia typify soil bacteria by having a high number of chemoreceptors and highlights the importance of the motility and chemotaxis mechanisms in a free‐living cell in the rhizosphere, and at different stages of the symbiosis.
From panic to banter: How do routine government releases and clarifications cause unexpected public opinion crisis—An analysis of public opinion toward a release by Chinese Ministry of Commerce encouraging the storage of necessities
Authors: Sun Qi , Chen Juan , Gao Shunheng
Published: January 2024

This research explored why a routine government notice caused a series of unexpected public opinion crises. We used K‐means clustering and Baidu Application Programming Interface Gateway to analyse 12,478 comments from Sina Weibo on Chinese Ministry of Commerce's release to encourage people to stock up necessities. Results show that even government's routine notice releases are regular events with relatively low objective risk, but in practice, how the government releases information and makes clarification would significantly infect public risk perception and emotion. First, ambiguous government releases magnify existing risks, especially during sensitive times, and resulting in heightened uncertainty, public risk perception and spread of negative emotions, therefore, lead to heated public discussion. Second, timely and effective clarifications can lower public risk perception as well as lead to positive emotions, although public banter may come along and generate another round of online public opinion within a short time. Our work answers why regular events would cause unexpected public opinion from the perspective of government behaviour, illustrates the dynamic interaction between government and online public opinion and can inform public policy aimed at more efficient communication with the public.
Keystone theories of postcrisis discourse: Communication Theory of Resilience and Discourse of Renewal
Authors: Seeger Matthew W. , Nowling William , Seeger Henry S.
Published: January 2024

Theories of resilience are keystones for understanding how individuals, small groups, organizations, and communities arrive at collective meaning, resolve uncertainty, and respond to crisis events. In response to a crisis, organizations can pursue three goals: Returning to the prior equilibrium, creating a new equilibrium with new processes and policies, or a combination of the two. Theories of resilience and renewal address these responses. Resilience has been applied in a diverse set of academic fields as well as in public policy discussions and in popular culture. This broad application, however, has resulted in conceptual confusion and conflicting interpretations. We explore the origins of resilience and its characteristics. We then review two discipline‐specific postcrisis theories, The Communication Theory of Resilience and Discourse of Renewal. We ask, how can these theories enrich understanding of postcrisis adaptive processes and create for a more comprehensive picture of how individuals and organizations respond to crises? Taken together, they provide a broader framework for understanding the role of postcrisis discourse and informing practitioners in the enactment of responses.