bluuebunny/crossref_metadata_2025 huggingface dataset:
The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways
Authors: Berkane Rayene , Ho-Xuan Hung , Glogger Marius , Sanz-Martinez Pablo , Brunello Lorène , Glaesner Tristan , Kuncha Santosh Kumar , Holzhüter Katharina , Cano-Franco Sara , Buonomo Viviana , Cabrerizo-Poveda Paloma , Balakrishnan Ashwin , Tascher Georg , Husnjak Koraljka , Juretschke Thomas , Misra Mohit , González Alexis , Dötsch Volker , Grumati Paolo , Heilemann Mike , Stolz Alexandra
Published: February 2023

Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and essential to maintain cellular homeostasis during environmental changes. We recently showed that members of the FAM134 family play a critical role during stress-induced ER-phagy. However, the mechanisms on how they are activated remain largely unknown. In this study, we analyzed phosphorylation of FAM134 as a trigger of FAM134-driven ER-phagy upon mTOR (mechanistic target of rapamycin) inhibition. An unbiased screen of kinase inhibitors revealed that CK2 is essential for FAM134B- and FAM134C-driven ER-phagy after mTOR inhibition. Furthermore, we provide evidence that ER-phagy receptors are regulated by ubiquitination events and that treatment with E1 inhibitor suppresses Torin1-induced ER-phagy flux. Using super-resolution microscopy, we show that CK2 activity is essential for the formation of high-density FAM134B and FAM134C clusters. In addition, dense clustering of FAM134B and FAM134C requires phosphorylation-dependent ubiquitination of FAM134B and FAM134C. Treatment with the CK2 inhibitor SGC-CK2-1 or mutation of FAM134B and FAM134C phosphosites prevents ubiquitination of FAM134 proteins, formation of high-density clusters, as well as Torin1-induced ER-phagy flux. Therefore, we propose that CK2-dependent phosphorylation of ER-phagy receptors precedes ubiquitin-dependent activation of ER-phagy flux.
Sing to me, baby: Infants show neural tracking and rhythmic movements to live and dynamic maternal singing
Authors: Nguyen Trinh , Reisner Susanne , Lueger Anja , Wass Samuel V. , Hoehl Stefanie , Markova Gabriela
Published: February 2023

Infant-directed singing has unique acoustic characteristics that may allow even very young infants to respond to the rhythms carried through the caregiver’s voice. The goal of this study was to examine neural and movement responses to live and dynamic maternal singing in 7-month-old infants and their relation to linguistic development. In total, 60 mother-infant dyads were observed during two singing conditions (playsong and lullaby). In Study 1 (n= 30), we measured infant EEG and used an encoding approach utilizing ridge regressions to measure neural tracking. In Study 2 (n= 40), we coded infant rhythmic movements. In both studies, we assessed children’s vocabulary when they were 20 months old. In Study 1, we found above-threshold neural tracking of maternal singing, with superior tracking of lullabies than playsongs. We also found that the acoustic features of infant-directed singing modulated tracking. In Study 2, infants showed more rhythmic movement to playsongs than lullabies. Importantly, neural coordination (Study 1) and rhythmic movement (Study 2) to playsongs were positively related to infants’ expressive vocabulary at 20 months. These results highlight the importance of infants’ brain and movement coordination to their caregiver’s musical presentations, potentially as a function of musical variability.
Compressive sensing-based de-aliasing method for array electrostatic signal
Authors: Zhong Zhirong , Jiang Heng , Guo Jiachen , Zuo Hongfu
Published: February 2023

Purpose

The aero-engine array electrostatic monitoring technology (AEMT) can provide more and more accurate information about the direct product of the fault, and it is a novel condition monitoring technology that is expected to solve the problem of high false alarm rate of traditional electrostatic monitoring technology. However, aliasing of the array electrostatic signals often occurs, which will greatly affect the accuracy of the information identified by using the electrostatic sensor array. The purpose of this paper is to propose special solutions to the above problems.

Design/methodology/approach

In this paper, a method for de-aliasing of array electrostatic signals based on compressive sensing principle is proposed by taking advantage of the sparsity of the distribution of multiple pulse signals that originally constitute aliased signals in the time domain.

Findings

The proposed method is verified by finite element simulation experiments. The simulation experiments show that the proposed method can recover the original pulse signal with an accuracy of 96.0%; when the number of pulse signals does not exceed 5, the proposed method can recover the pulse peak with an average absolute error of less than 5.5%; and the recovered aliased signal time-domain waveform is very similar to the original aliased signal time-domain waveform, indicating that the proposed method is accurate.

Originality/value

The proposed method is one of the key technologies of AEMT.
Employee engagement and performance of MSMEs during COVID-19: the moderating effect of job demands and job resources
Authors: Coffie Rosemary Boateng , Gyimah Raymond , Boateng Kofi Agyenim , Sardiya Alimatu
Published: February 2023

Purpose

This study explores how employee engagement (EE) influences employee performance and how this relationship is moderated by job demands and job resources among micro, small and medium enterprises (MSMEs) in an emerging economy context during the COVID-19 pandemic.

Design/methodology/approach

The study adopts the survey and quantitative approach to gathering data from 395 MSMEs operating in an emerging economy in sub-Saharan Africa. Data were analyzed using Partial Least Squares, version 3.0.

Findings

The results reveal that EE significantly influences employee performance among MSMEs during the pandemic. Also, job resources were found to be significant predictors of EE in the MSME sector. In contrast, job demands did not have a significant effect on EE during the pandemic. Finally, job resources but not job demand moderate the relationship between EE and employee performance.

Originality/value

This study is one of the earliest to explore the effects of EE on employee performance and how this relationship is moderated by job resources and job demands in sub-Saharan Africa's MSME sector since the influx of COVID-19.
Lessons learnt from COVID-19 vaccine operations and distribution performance: challenges and resilience strategies
Authors: Chowdhury Md. Maruf Hossan , Mahmud A.K.M. Shakil , Khan Eijaz , Hossain Mohammad , Barua Zapan
Published: February 2023

Purpose

Grounded in dynamic capability view, this research develops a decision support model, which enables determining consistent and sufficient configurations of resilience strategies to mitigate vaccine operations and distributions (O&D) challenges and thus improve O&D performance (i.e. O&DP).

Design/methodology/approach

Through qualitative in-depth interviews, the authors first identified challenges and resilience strategies related to vaccine O&D. Next, using the quality function deployment technique, three quantitative case studies were performed to determine the most important challenges and resilience strategies. Finally, utilising fuzzy set qualitative comparative analysis, the authors determine sufficient conditions of challenges and strategies leading to improve vaccine O&DP.

Findings

The findings reveal that strategies alone are not effective instead a combination of strategies and nullification of challenges is needed to enhance vaccine O&DP. Further, the findings revealed that not only the presence of challenges, but also the lack of strategies reduces the vaccine O&DP.

Practical implications

The authors' findings will assist the health service decision-makers for strategizing an effective and efficient vaccination program by selecting the right combination of challenges and resilience strategies.

Originality/value

The authors' study develops a novel decision support model and offers significant learning for the future vaccine O&DP.
A meta-analysis of social commerce adoption and the moderating effect of culture
Authors: Wang Ning , Zhao Yang , Zhou Ruoxin
Published: February 2023

Purpose

As a derivative model of e-commerce, social commerce has received increasing attention in recent years. Empirical studies on social commerce have examined the key factors that influence users' attitudes or adoption intentions, but their conclusions are context-based and are not entirely consistent. This study aims to draw a general conclusion by systematically synthesizing the findings of previous studies and examine whether cultural differences play a moderating role in users' social commerce adoption.

Design/methodology/approach

A meta-analysis based on 11,786 independent samples from 39 empirical studies was conducted to integrate their results and develop a comprehensive conceptual model. A moderator analysis was carried out to investigate the moderating effect of culture by dividing the context into subgroups of individualistic and collectivistic cultures.

Findings

The results show that this comprehensive conceptual model can help better understand the adoption of social commerce. Meanwhile, the moderator analysis indicates that cultural differences have a significant moderating effect on the relationship between the determinants and the adoption of social commerce.

Originality/value

The findings of this paper have theoretical implications and make managerial contributions.
Organizational readiness for building information modeling
Authors: Magalhães Rachel Madeira , Mello Luiz Carlos Brasil de Brito , Hippert Maria Aparecida Steinherz
Published: February 2023

Purpose

The main factor that leads organizations to implement Building Information Modeling (BIM) is customer demand. While this is a frequent topic in the BIM literature, few studies address BIM organizational readiness. Due to this gap in BIM implementation literature, this paper aims to understand what affects organizational BIM readiness and how the BIM readiness process occurs.

Design/methodology/approach

The present paper adopts design science research as a methodological approach. A literature review examined 69 journal articles. The analysis focused on multiple theories, such as organizational readiness for change, adoption and diffusion of innovations and project management.

Findings

By investigating BIM organizational readiness, this study presents a construct and a conceptual model for driving BIM readiness.

Originality/value

This study can benefit researchers and organizations. The results presented may drive further research and discussions on the topic. But it is important to state that these results must be tested on real situations.
The Indian contribution to organizational institutionalism: implications for organizational theorizing
Authors: Shekhar Sudhanshu
Published: February 2023

Purpose

Organization studies in India has largely remained insular to the writings of Indian scholars in parent disciplines such as sociology. The lack of engagement with Indian sociological works has promoted excessive dependence on Euro–American theory. It has further hindered the development of indigenous theories. This paper aims to argue that engagement with the writings of classical and contemporary Indian sociologists can resolve this issue.

Design/methodology/approach

The paper delineates the contribution of Indian sociologists to organizational or sociological institutionalism. It focuses specifically on the contribution of these scholars concerning two subtopics: conceptualization of institutions and fields, and the dynamics of institutional change.

Findings

The paper draws upon the work of Indian sociologists to develop a concept of ecological field. It further delves into the dynamic interplay between ideas and institutional change. More precisely, it draws attention to the role of actors and mechanisms that produce ideas.

Originality/value

Future studies can leverage the contribution of Indian scholars to explicate, elaborate and develop creative theories of organizational institutionalism. Such cumulative efforts can help in building an Indian tradition of organizational institutionalism.
Nash equilibrium in emerging partnership-based Islamic banking industry with a Bayesian game-theoretic approach
Authors: Ghaemi Asl Mahdi , Ghasemoghli Ali , Khalfaoui Rabeh
Published: February 2023

Purpose

A hypothesis developed in this paper models the relationship between the borrower and the bank as a dynamic game based on incomplete information (business game) and seeks an equilibrium point at which the facilitated applicant can act according to the terms of the loan agreement once the contract is signed and meet the requirements of the contract.

Design/methodology/approach

The primary assumption in the formation of the Islamic bank in Islamic society is that the members of the society are Muslims and act according to religious orders. However, the non-fulfillment of divine principles and orders is always possible. In partnership agreements, the risk of infringement is reduced and corrupt contracts are prevented in some circumstances. Our basic model was constructed using the Beer-Quiche classic game, which has been modified dynamically along with a generalization of complexity terms. The information asymmetry led us to use a heterogeneous belief system to evaluate the probability of the customer transmitting a low credit risk signal to the bank and the probability of the customer transmitting a high credit risk signal to the bank. There are several assumptions of the basic model that are released in the extended model by the presence of a social inspector, by exploring credit risk signals in the generalized model and by considering various commitment levels in the comprehensive model.

Findings

As a result, it is observed that there is no Nash equilibrium in cases where the customer applies separation strategies. But if the pulling strategies are applied, the Nash equilibrium can be achieved under certain conditions, including inspection bodies in the banking system, the creation of necessary transparency and the proper treatment of criminals by government and regulatory bodies. So, by using alternative belief systems, applying different filters and paying attention to all sectors of the economy, new Nash equilibrium points can be achieved. Moreover, multi-stage facilities payment reduces the risk of corrupt contracts.

Originality/value

This paper sets out to analyze Nash Equilibrium and its possible encounter in Islamic Banking for the first time, utilizing a Bayesian Game-Theoretic framework. A major aspect of the research is the contribution to a better understanding of the role of transparency and government oversight in the implementation of Islamic banking regulatory standards.
Chrysalis of crisis: Covid-19 as a catalyst for awakening power and justice in a luxury fashion supply chain
Authors: Karaosman Hakan , Marshall Donna , Villena Verónica H.
Published: February 2023

Purpose

The purpose of this paper is to understand how supply chain actors in an Italian cashmere supply chain reacted to dependence and power use during the Covid-19 crisis and how this affected their perceptions of justice.

Design/methodology/approach

The research took a case study approach exploring issues of dependence, power and justice in a multi-tier luxury cashmere supply chain.

Findings

The authors found two types of dependence: Craftmanship-induced buyer dependence and Market-position-induced supplier dependence. The authors also identified four key archetypes emerging from the dynamics of dependence, power and justice during Covid-19. In the repressive archetype, buying firms perceive their suppliers as dependent and use mediated power through coercive tactics, leading the suppliers to perceive interactional, procedural and distributive injustice and use reciprocal coercive tactics against the buying firms in the form of coopetition. In the restrictive archetype, buying firms that are aware of their dependence on their suppliers use mediated power through contracts, with suppliers perceiving distributive injustice and developing ways to circumvent the brands. In the relational archetype, the awareness of craftmanship-induced buyer dependence leads buying firms to use non-mediated power through collaboration, but suppliers still do not perceive distributive justice, as there is no business security or future orders. In the resilient archetype, buying firms are aware of their own craftmanship-induced dependence and combine mediated and non-mediated power by giving the suppliers sustainable orders, which leads suppliers to perceive each justice type positively.

Originality/value

This paper shows how the actors in a specific supply chain react to and cope with one of the worst health crises in living memory, thereby providing advice for supply chain management in future crises.
To what extent can collaborative platforms in urban planning education enhance transformative learning outside of academia?
Authors: Čolić Ratka , Milovanović Rodić Danijela , Fokdal Josefine
Published: February 2023

Purpose

This paper aims to explore the effects of collaborative innovation (CI) in urban planning practice by investigating the influence of a platform for collaboration between academia and external partners (practitioners and community groups). Unlike previous research on learning outcomes from the perspective of students (Fokdal et al., 2020), the aim of this article is to investigate the transformative learning (TL) experience from the perspective of the external partners.

Design/methodology/approach

The outcomes of the TL experience were assessed through four elements: disorienting dilemma; critical reflection; engagement in discourse; and reflective and critical taking action.

Findings

The claim that collaboration with multiple actors through TL processes can help promote innovative ways to view and practice planning outside of academia has to a certain extent been confirmed. This paper provides evidence that such transformative processes can have an impact on the individuals involved and shows the importance of individuals acting as change agents – or drivers of innovation. In addition, the importance of a collaborative platform – acting as an intermediary – in facilitating TL processes in planning practices is highlighted in the context of Serbia.

Originality/value

This paper is a continuation of existing research on educational initiatives that attempt to integrate sustainability into the curricula and bring innovation to urban planning practice; showcase outcomes of the TL experience for sustainable development, especially when addressing the innovative ways that planning is practiced outside of academia; and push for change toward a more sustainable future not only within and but also outside of academia.
Exploration of the applicability of the front-of-package nutrition label to advertising in comparison with the label on the product package
Authors: Shin Sumin , Park SangHee
Published: February 2023

Purpose

A front-of-package label is a simple and effective way to communicate nutrition information to consumers. However, the use of the label has been limited to product packages. The purpose of this study is to explore the applicability of a front-of-package label to food print advertisements and to examine how the degree of nutrient content on the label influences consumer perceptions and behavioral intention.

Design/methodology/approach

Many food product manufacturers voluntarily use a front-of-package nutrition label showing specific information per serving size for calories, saturated fat, sodium and sugar. This exploratory, experimental research evaluates the thoughts, feelings and behavioral intention changes of consumers in response to a front-of-package label on a print advertisement and a product package. Two experiments were conducted online.

Findings

The presence of a front-of-package label in the ad increases ad responses involving perceived healthfulness of the product, ad attitude, brand attitude, healthy brand image and purchase intention. In addition, the healthier nutrient content listed on the label positively affects the audience’s responses. However, the front-of-package label on the product package increases only perceived healthfulness. Information about the degree of nutrient content indirectly influences intention to purchase the advertised healthy/unhealthy product sequentially via perceived healthfulness of the product, ad attitude, brand attitude and healthy brand image.

Research limitations/implications

To generalize the results, various product categories should be tested with the same research design in future studies.

Practical implications

This study recommends that communication practitioners place a front-of-package label on their print advertisements even though the food is not healthy. However, practitioners should keep in mind that a front-of-package label does not increase sales in the long term if the product is unhealthy.

Originality/value

The major contribution of this study is its exploration of the applicability of a front-of-package label to the advertising context. The label plays a role as a message cue a consumer can use to evaluate the ad, brand and product.
What price Romania has to pay for being one of the main providers of physicians in Europe?
Authors: Apostu Simona Andreea , Akkaya Bulent
Published: February 2023

Purpose

The migration of physicians is a global interest, causing imbalances between developed and developing countries. Romania is one of Europe's major providers of physicians, not because there is a surplus, but because physicians are drawn to places with better living and working conditions. Medicine in Romania is increasingly highly advanced, and Romanian physicians are well appreciated all over the world. Despite being one of the countries with the most medical graduates in the world, Romania is suffering a doctor exodus. After joining the EU, the problem of physician migration became widespread, resulting in a deficient and inefficient healthcare system. Therefore, the purpose of this study is to estimate the losses registered by Romania because of physicians' decision to migrate.

Design/methodology/approach

These losses were calculated in two ways: utilizing the statistical life value and the amount of money invested in training a medical graduate.

Findings

According to the findings, the losses in 2018 were 104.16 million euros, approximately 0.12% of GDP.

Originality/value

The originality of this paper consists in data, being provided by the College of Physicians from Romania and the method used, this study being the only one that estimates the cost of Romanian physicians' migration. The paper adds to existing knowledge an empirical results regarding quantifying the value reflecting the departure of physicians, using value of statistical life and the amount of money invested in preparing a medical graduate.
Advancing the model of social entrepreneurial intention: the role of perceived financial security
Authors: Ukil Minhajul Islam , Ullah Muhammad Shariat , Hsu Dan K.
Published: February 2023

Purpose

Although few studies indicate that financial concerns matter to social entrepreneurs, the literature is unclear about the extent to which a financial motive affects the intention to start a new social enterprise. Moreover, prior research suggests that the intention to start a new enterprise heavily depends on the societal context in which the enterprise operates. Therefore, this study aims to examine the seminal model of social entrepreneurial intention (SEI) developed by Hockerts (2017) in a different social context; additionally, it proposes a new antecedent of SEI – perceived financial security.

Design/methodology/approach

This study used two different measurement scales and samples (n = 436 and 241) in a developing country to validate the model and propose a new antecedent, i.e. the perceived financial security, of SEI. Furthermore, the authors employed the partial least square-structural equation model to test the hypotheses.

Findings

The results demonstrate that social entrepreneurial self-efficacy, perceived social support and perceived financial security directly predict SEI; they further mediate the relationship between prior experience and SEI. Consequently, the model by Hockerts is extended.

Originality/value

This study established perceived financial security as a strong antecedent of SEI, thereby offering a novel insight that a social entrepreneur can be motivated by potential financial concerns.
IN THE SHADOW OF ‘THE CITY’ YET TO COME: Auroville, Developmentalism and the Social Effects of Cityness
Authors: Jazeel Tariq
Published: February 2023

This article focuses on the planned community of Auroville in Tamil Nadu, India, founded in 1968. Building on critical readings of the settlement that have drawn attention to the power imbalance in its relationships with surrounding villages, the article delineates the ways that a geographical imagination of cityness has been a key component of the settlement's development and the forms of neo‐coloniality in which it has been implicated. Drawing on archival and published sources as well as ethnographic research, the article discusses three ways in which the settlement performs a sense of its own ‘cityness‐to‐come’: first, the architectural discourse and planning rationality central to Auroville's identity; second, its agonistic public sphere vis‐à‐vis architecture and planning, and third, its ethos of learning and evolution, and the settlement's developmental teleology. In so doing, the article shows how ‘the city’ conceived as a textual and spatial promise, as well as a utopian aspiration, works ideologically to constitute the settlement itself, but also to precipitate social effects and uneven power relationships with village communities in this region. To sum up, this article develops an argument about the neo‐colonial social work done by ‘the city’ conceived as text.
Tranexamic acid, as an adjunct to oxytocin prophylaxis, in the prevention of postpartum haemorrhage in women undergoing elective caesarean section: A single‐centre double‐blind randomised controlled trial
Authors: Lee Shi Hui , Kwek Michelle E‐Jyn , Tagore Shephali , Wright Ann , Ku Chee Wai , Teong Aimee Chuin Ai , Tan Amanda Wei Mun , Lim Santi Wei Che , Yen Desiree Yu Ting , Ang Cassandra Yang Xuan , Sultana Rehena , Lim Celeste Hong Fei , Mathur Deepak , Mathur Manisha
Published: February 2023

Objective

To evaluate the effectiveness of tranexamic acid (TXA) in reducing blood loss during elective caesarean sections in women with and without risk factors for postpartum haemorrhage (PPH).

Design

A double‐blind, randomised placebo‐controlled trial.

Setting

An academic tertiary referral centre in Singapore.

Population

Multiethnic women aged 21 years or older undergoing elective caesarean section.

Methods

Randomisation to intravenous TXA or normal saline (placebo) 10 minutes before skin incision.

Main outcome measures

Calculated estimated blood loss (cEBL), derived from blood volume and haematocrit levels.

Results

Between June 2020 and October 2021, 200 women were randomised to the placebo or TXA groups. Women who received prophylactic TXA had a significantly lower mean cEBL compared with those receiving placebo (adjusted mean difference −126.4 mL, 95% CI −243.7 to −9.1, p = 0.035). The effect was greatest in those at high risk for PPH, with a reduction in cEBL (mean difference −279.6 mL, 95% CI −454.8 to −104.3, p = 0.002) and a lower risk of cEBL ≥500 mL (risk ratio [RR] 0.54, 95% CI 0.36–0.83, p = 0.007) and cEBL ≥1000 mL (RR 0.44, 95% CI 0.20–0.98, p = 0.016). Subgroup analysis showed benefit for women with preoperative haemoglobin <10.5 g/dL (mean difference −281.9 mL, 95% CI −515.0 to −48.8, p = 0.019). There was no significant difference in need for additional medical or surgical interventions. There were no maternal or neonatal adverse outcomes.

Conclusion

Prophylactic TXA should be considered in women with risk factors for PPH, and those most likely to benefit are those with preoperative haemoglobin <10.5 g/dL.
Spatial acclimation of elk during population restoration to the Missouri Ozarks, USA
Authors: Pero E. M. , Palm E. C. , Chitwood M. C. , Hildreth A. M. , Keller B. J. , Sumners J. A. , Hansen L. P. , Isabelle J. L. , Millspaugh J. J.
Published: February 2023

Wildlife translocations are an important conservation tool but can be challenging for the animals. For translocations to be successful, animals must adjust to their release landscape. Investigating how animals acclimate to their release landscapes can improve post‐release monitoring and inform about the management needs of translocated populations. We investigated movements and resource selection dynamics of 106 elk (Cervus canadensis) during the first 6–8 years following their release to Missouri, USA in 2011–2013. We observed evidence of spatial acclimation as determined by cessation of changes in resource selection together with monthly range sizes and fidelity of individual elk. Females showed faster evidence of acclimation in their movements following release than males. Although range fidelity for both sexes stabilized within approximately seven months, range size stabilized within approximately three months for females and stabilization began within approximately 11 months for males. Selection for multiple resources by elk also largely stabilized within their first year following release. A simple refuge‐forage trade‐off alone did not explain acclimation in resource selection. Elk selected for high‐quality food plots across the temporal extent of restoration regardless of time since release, whereas their selection for cover resources during summer increased after elk acclimated. Together, spatial acclimation generally lagged behind physiological responses observed in this system, adding to the increasing evidence that translocated animals display acclimation patterns across trait‐specific time periods. Our approach demonstrates the utility of accounting for acclimation effects across multiple spatial response metrics for improving post‐release monitoring, evaluation, and management of restored wildlife populations.
Influence of the maternity unit and region of delivery on episiotomy practice in France: a nationwide population‐based study
Authors: Cormier Julie , Merrer Jade , Blondel Béatrice , Le Ray Camille
Published: February 2023

Introduction

Our objective was to identify factors associated with episiotomy practice in France, in particular, characteristics of the maternity units and regions of delivery.

Material and methods

We performed a national cross‐sectional population‐based study in all French maternity units in 2016 including 9284 women with vaginal delivery. Our outcome was the performance of an episiotomy. After stratification for parity, associations of episiotomy practice with individual and organizational characteristics and the region of delivery were estimated with multilevel logistic regression models. The variability in maternity unit episiotomy rates explained by the characteristics studied was estimated by the proportional change in variance.

Results

A total of 19.9% of the women had an episiotomy. The principal factors associated with episiotomy practice were maternal and obstetric and delivery in a maternity unit with <2000 annual deliveries. After adjusting for individual, obstetric and organizational characteristics, the practice of episiotomy was strongly associated with women's region of delivery. Additionally, women's individual characteristics did not explain the significant variability in episiotomy rates between maternity units (P < 0.001) but maternity unit characteristics partly did (proportion of variance explained: 7.2% for primiparas and 13.6% for multiparas) and regional differences still more (18% and 30.7%, respectively).

Conclusions

Episiotomy practices in France in 2016 varied strongly between maternity units, largely due to regional differences. Targeted actions by the regional perinatal care networks may reduce the national episiotomy rate and standardize practices.
Evolving alliance between corporate environmental performance and financial performance: A bibliometric analysis and systematic literature review
Authors: Chowdhury Seemita Bose , DasGupta Ranjan , Choudhury Binoy Krishna , Sen Nabinananda
Published: February 2023

This study aims to overview the existing literature, knowledge framework, and intellectual structure mapping in the field of corporate environmental performance (CEP) and corporate financial performance (CFP) by employing a bibliometric analysis approach to selected 311 papers sourced from the Scopus database between 1994 and 2022. It presents the publication growth, influential sources, productive authors, and collaboration index of countries using Biblioshiny software. Stringent regulatory regime and stakeholders' pressure followed by a growing trend of publication motivated us to comprehend the evolving facets of the relationship using co‐citation analysis followed by a systematic literature review using coupling analysis which identified five research themes as CEP–CFP relationships—facets, strategies and dimensions, and methodological choices during the initial phase of 1994–2014; and green innovation and corporate sustainability practices, environmental disclosure and environmental responsibility, and green development behavior and practices during 2015–2022. From the insights congregated from research themes, the study discusses prominent developments and provides future research directions to further enrich the field of CEP and CFP. Our findings provide various global regulatory frameworks, government, policymakers, and firm managers the need to explore the dynamic factors while formulating the strategic environmental policy and how it contributes to the financial performance of the firms.
Effects of opium tincture on the enteric and central nervous systems: A randomized controlled trial
Authors: Okdahl Tina , Mark Esben Bolvig , Nedergaard Rasmus Bach , Knoph Cecilie Siggaard , Cook Mathias Ellgaard , Krogh Klaus , Drewes Asbjørn Mohr
Published: February 2023

Opioids change gut motility, and opium tincture has been used for treatment of chronic diarrhoea for centuries. However, the effects have never been documented in controlled trials. We aimed to investigate the effects of opium tincture on gastrointestinal transit and motility, frequency of bowel movements, stool consistency, gastrointestinal symptoms and sedation. Twenty healthy subjects were included in this randomized controlled trial. Opium tincture or placebo was each applied for 9 days. Gastrointestinal transit and motility were investigated with the 3D‐transit system. Bowel movements and gastrointestinal symptoms were recorded daily. General cognition, reaction time, memory and electroencephalography were used to assess effects on the central nervous system. Opium tincture doubled colonic transit (49 vs. 23 h, p < 0.001), decreased antegrade colonic movements (p < 0.05), reduced daily bowel movements (0.7 vs. 1.2, p < 0.001) and increased stool consistency (Type 3 vs. Type 4, p < 0.001). No changes in general cognition, reaction time or memory were observed, and minor changes of power observed by electroencephalography did not indicate sedation. This study is the first to show that opium tincture has anti‐propulsive properties in the healthy gut, while no sedative effects were seen. This indicates that opium tincture is a relevant and safe treatment option in chronic diarrhoea.
Profiles of Chinese preschoolers' academic and social–emotional development in relation to classroom quality: A multilevel latent profile approach
Authors: Huang Runke , Siraj Iram
Published: February 2023

Linking classroom quality to separate domains of child development might neglect the transactional interactions across developmental domains. This research utilized latent profiles across academic and social–emotional development to explore which aspects of classroom quality can predict children's profiles at the classroom level. Data were drawn from 96 preschool classrooms and 547 children (3–5 years old) in China in 2020. Multilevel latent profile analysis identified three profiles (entitled low‐, average‐ and high‐level development at the individual level), and two classes (entitled average and below‐, average and above) at the classroom level. Multinominal logistic regression analyses revealed that instructional quality in math, science, and diversity, and the interactional quality in supporting children's learning and critical thinking, predicted children's profiles.
Anti‐dumping Policies and International Portfolio Allocation: The View from the Global Funds
Authors: Ding Haoyuan , Li Xiao , Ying Jiezhou
Published: February 2023

Anti‐dumping policies, as one of the most important nontariff measures to protect a country's economic interests, can have an impact not only on a country's trade and social welfare, but also on capital flows. Anti‐dumping measures can result in increased trade costs and alterations to exchange rate risk. This study investigates the impact of anti‐dumping sanctions on the international portfolio allocations of global funds. Antidumping policies can decrease the proportion of a fund's investment portfolio allocated to recently‐sanctioned countries. Closer trade ties between the sanctioned country and the country where a fund is domiciled exacerbate the divestiture, but stronger foreign direct investment links weaken the negative association. Some country and fund heterogeneities are also discussed. We find that more developed countries are less affected by the impact of anti‐dumping measures on equity fund allocations; liberalization of the economy and stable government could also mitigate the negative impact of anti‐dumping sanctions. High‐risk funds, such as growth funds or funds that invest in leveraged buyouts, showed the greatest response to changes in anti‐dumping regulations.
Metformin counters oxidative stress and mitigates adverse effects of radiation exposure: An overview
Authors: Karmanova Ekaterina , Chernikov Anatoly , Usacheva Anna , Ivanov Vladimir , Bruskov Vadim
Published: February 2023

Metformin (1,1‐dimethylbiguanidine hydrochloride) (MF) is a drug that has long been in use for the treatment of type 2 diabetes mellitus and recently is coming into use in the radiation therapy of cancer and other conditions. Exposure to ionizing radiation disturbs the redox homeostasis of cells and causes damage to proteins, membranes, and mitochondria, destroying a number of biological processes. After irradiation, MF activates cellular antioxidant and repair systems by signaling to eliminate the harmful consequences of disruption of redox homeostasis. The use of MF in the treatment of the negative effects of irradiation has great potential in medical patients after radiotherapy and in victims of nuclear accidents or radiologic terrorism.
Predictors of online health information seeking behaviour of non‐medical undergraduate students might vary
Authors: Adegbilero‐Iwari Oluwaseun Eniola , Oluwadare Tunrayo , Adegbilero‐Iwari Idowu
Published: February 2023

Background

As more people across Generations X, Y, and Z continue to use the Internet meet their information needs, this study assesses the characteristics influencing the online health information seeking behaviour (OHISB) of non‐medical university students. Previous studies on the subject in Nigeria have largely assessed the concept of OHISB among university students without examining the determinants of such behaviour.

Objective

To determine the predictors of OHISB among non‐medical undergraduate students of a Nigerian private university.

Methods

Adopting a cross‐sectional research design, the study utilized a semi‐structured questionnaire administered via Google forms. Some 361 non‐medical undergraduate students were recruited purposively with a response rate of 84.2%. The questionnaire obtained data on students' socio‐demographics, Internet usage, and OHISB.

Results

Presence of a chronic condition, gender, and college showed significant associations with students' OHISB. ‘Mothers' occupation’ and ‘prior experience’ became significant predictors of students' OHISB.

Discussion

The results align with studies that stressed that chronically ill persons would search for health information on the internet and that presence of chronic illness is among the predictors of OHISB.

Conclusion

These findings add to evidence from other countries that had identified health literacy and presence of chronic illness as significant predictors of OHISB among students.
Molecular correlates of invasion pattern in HPV‐associated endocervical adenocarcinoma: emergence of two distinct risk‐stratified tiers
Authors: Sharma Aarti E , Hodgson Anjelica J , Howitt Brooke E , Olkhov‐Mitsel Ekaterina , Djordevic Bojana , Park Kay J , Nucci Marisa R , Parra‐Herran Carlos
Published: February 2023

Background

The pattern‐based (Silva) classification of invasive human papilloma virus (HPV)‐associated endocervical adenocarcinomas (HPVA) is an established and reproducible method to predict outcomes for this otherwise stage‐dependent group of tumours. Previous studies utilising targeted sequencing have shown a correlation between mutational profiles and an invasive pattern. However, such correlation has not been explored using comprehensive molecular testing.

Design

Clinicopathologic data including invasive pattern (Silva groups A, B, and C) was collected for a cohort of invasive HPVA, which previously underwent massive parallel sequencing using a panel covering 447 genes. Pathogenic alterations, molecular signatures, tumour mutational burden (TMB), and copy number alterations (CNA) were correlated with pattern of invasion.

Results

Forty five HPVA (11 pattern A, 17 pattern B, and 17 pattern C tumours) were included. Patients with pattern A presented at stage I with no involved lymph nodes or evidence of recurrence (in those with >2 months of follow‐up). Patterns B and C patients also mostly presented at stage I with negative lymph nodes, but had a greater frequency of recurrence; 3/17 pattern B and 1/17 pattern C HPVAs harboured lymphovascular space invasion (LVI). An APOBEC mutational signature was detected only in Silva pattern C tumours (5/17), and pathogenic PIK3CA changes were detected only in destructively invasive HPVA (patterns B and C). When cases were grouped as low‐risk (pattern A and pattern B without LVI) and high‐risk (pattern B with LVI and pattern C), high‐risk tumours were enriched in mutations in PIK3CA, ATRX, and ERBB2. There was a statistically significant difference in TMB between low‐risk and high‐risk pattern tumours (P = 0.006), as well as between Pattern C tumours with and without an APOBEC signature (P = 0.002). CNA burden increased from pattern A to C.

Conclusion

Our findings further indicate that key molecular events in HPVA correlate with the morphologic invasive properties of the tumour and their aggressiveness. Pattern B tumours with LVI clustered with pattern C tumours, whereas pattern B tumours without LVI approached pattern A genotypically. Our study provides a biologic foundation for consolidating the Silva system into low‐risk (pattern A + B without LVI) and high‐risk (pattern B with LVI and pattern C) categories.
How blockchain adoption affects supply chain sustainability in the fashion industry: a systematic review and case studies
Authors: Chen Yue
Published: February 2023

The fashion industry is the fourth biggest industry globally, with a value of $3 trillion and a workforce of 3384 million. However, the rapid development of the fashion industry negatively impacts the environment. With industrial practice, blockchain technology is found to be efficient and effective in helping fashion supply chain members cope with sustainability issues with accessibility, security, traceability, and transparency. This paper makes a systematic literature review and in‐depth exploration of adopting blockchain technology to facilitate sustainable supply chain practices with a particular case study on the fashion industry in coastal areas and a discussion of the application of blockchain technology in the global fashion industry. Based on the combination of the literature review, the case study, and the discussion, managerial insights are generated concerning blockchain adoption for boosting sustainability in the fashion industry in various domains. Future research opportunities are also discussed.
Incidence and risk factors for surgical site infection after medial opening‐wedge high tibial osteotomy using a locking T‐shape plate
Authors: Jia Guoxing , Sun Congcong , Xie Jin , Li Jia , Liu Sen , Dong Wei , Yu Xiaoguang
Published: February 2023

Medial opening‐wedge high tibial osteotomy (MOWHTO) is a well‐established surgical method for treatment of isolated medial compartment osteoarthritis with varus deformity, but the surgical outcomes may be compromised by surgical site infection (SSI). This study aimed to investigate the incidence and the risk factors for SSI after MOWHTO. This retrospective study included consecutive patients who underwent MOWHTO for isolated medial compartment osteoarthritis with varus deformity in two tertiary referral hospitals from January 2019 and June 2021. Patients who developed SSI within 12 months of surgery were identified by inquiring the medical records for index hospitalisation, notes of after‐discharge outpatient visits, or records of readmission for treatment of SSI. Univariate comparisons were performed to detect the differences between SSI and non‐SSI groups, and multivariate logistic regression analysis was used to identify the independent risk factors. Six hundred sixteen patients with 708 procedures were included and 30 (4.2%) cases of SSI occurred, with 0.6% rate for deep SSI and 3.6% for superficial. Univariate analyses showed significant difference between groups in terms of morbidity obesity (≥32 kg/m2) (20.0% vs 8.9%), comorbid diabetes (26.7% vs 11.1%), active smoking (20.0% vs 6.3%), time from admission to operation (5.2 ± 4.0 vs 4.1 ± 3.0), size of osteotomy ≥12 mm (40.0% vs 20.0%), type of bone grafting and lymphocyte count (2.1 ± 0.5 vs 1.9 ± 0.6). However, in the multivariate analysis, only active smoking (OR, 3.4; 95% CI, 1.4‐10.2), size of osteotomy ≥12 mm (OR, 2.8; 95% CI, 1.3‐5.9) and allogeneic/artificial vs no bone grafting (OR, 2.4; 95% CI, 1.0‐10.8) remained significant. SSI was not uncommon after MOWHTO, but the majority was superficial. The identified three independent factors, including smoking, size of osteotomy ≥12 mm and allogeneic/artificial bone grafting would help risk assessment and stratification, target risk factor modification and clinical surveillance, and inform patient counselling.
Macroeconomic News in Asset Pricing and Reality
Authors: DUFFEE GREGORY R.
Published: February 2023

Revisions in successive Greenbook forecasts of quarterly real GDP growth proxy for news of current and expected future economic growth. In the sample 1975 through 2015, news of future growth is slightly negatively related to contemporaneous changes in Treasury bond yields, while news of current growth is strongly positively related to changes in these yields. Both results are difficult to reconcile with a representative agent's bondholding first‐order condition. A continuous‐time dynamic model of output attributes almost all of the covariation with yields to martingale innovations in log output and a minimal amount to innovations in the conditional drift of log output.