bluuebunny/crossref_metadata_2025 huggingface dataset:
TEORI BELAJAR HUMANISTIK DAN PENERAPANNYA DALAM PEMBELAJARAN PENDIDIKAN AGAMA ISLAM
Authors: Sultani Sultani , Alfitri Alfitri , Noorhaidi Noorhaidi
Published: July 2023

Metode pembelajaran Pendidikan Agama Islam  (PAI) konservatif tidak mampu mencapai tujuan pembelajarannya karena hanya menghasilkan siswa yang paham secara materi saja padahal ada aspek materi PAI yang perlu dipraktikan pada kegiatan sehari-hari. Teori belajar humanistik dianggap mampu untuk mengatasi kekurangan ini. Penelitian ini bertujuan untuk mengkaji teori humanistik dan penerapannya dalam pembelajaran PAI di Sekolah. Metode penelitian yang digunakan adalah library research dengan pendekatan kualitatif. Data diperoleh dari studi kepustakaan dan analisis dokumen terkait teori humanistik dan pembelajaran PAI di Sekolah. Teknik pengolahan dan analisis data menggunakan metode analisis isi untuk mengukur tingkat ketepatan pesan dan menarik kesimpulan. Langkah-langkah yang diterapkan adalah deskriptif, analisis isi dan korelatif. Hasil penelitian menunjukkan bahwa teori humanistik dapat diaplikasikan dalam pembelajaran PAI dengan mengutamakan aspek-aspek personalisasi, pemberdayaan, dan pengalaman. Pembelajaran PAI di Sekolah harus mampu memahami perubahan masyarakat dan teknologi, serta memanfaatkan teknologi informasi dan komunikasi untuk meningkatkan efektivitas pembelajaran. Penerapan teori humanistik dalam pembelajaran PAI dapat meningkatkan motivasi dan prestasi belajar siswa, serta membantu siswa untuk mengembangkan potensi diri secara maksimal, baik dari aspek psikologis, fisik, emosional dan spiritual. Selain itu, penerapan teori belajar humanistik dalam pembelajaran PAI dapat membantu siswa untuk mengembangkan keterampilan sosial seperti rasa empati, toleransi, dan moderat atau sikap terbuka terhadap perbedaan. Oleh karena itu, perlu adanya upaya untuk meningkatkan pemahaman dan penerapan teori belajar humanistik dalam pembelajaran PAI di Sekolah, sehingga dapat membantu menciptakan generasi yang lebih berdaya saing dan berkarakter.
PENERAPAN GAYA KEPEMIMPINAN SITUASIONAL DALAM RANGKA MENINGKATKAN EFEKTIFITAS PEMBELAJARAN DI SDN KERTAMULYA 3
Authors: Aisyah Siti , Akil Akil , Nurlaeli Acep
Published: July 2023

Tujuan dari jurnal ini adalah memperbaiki gaya kepemimpinan dalam mengajar Guru yang dapat meningkatkan efektifitas pengajaran kepada siswa dan kepala sekolah yang mengembangkan fasilitas dan menginstruksikan guru dalam pembelajaran. Kepemimpinan situasional siswa mempengaruhi peran guru sebagai pemimpin pembelajaran. Obeservasi dilaksanakan pada bulan Mei di SDN Kertamulya III. Dengan di adakannya observasi ini agar mengetahui peningkatan dalam gaya mengajar guru dalam pengelolaan kelas dan lebih efektivitas dalam pengajaran
IMPLEMENTASI INSTRUMEN EVALUASI PEMBELAJARAN DI TK RIZKY ANANDA
Authors: Aulia Putri , Nurlaili Nurlaili
Published: July 2023

Evaluasi pembelajaran perlu dilakukan untuk mengetahui capaian pembelajaran yang diperoleh anak. Evaluasi ini membutuhkan jenis instrumen untuk mempermudah proses penilaian. Penelitian ini bertujuan untuk mendeskripsikan jenis instrumen yang ada di TK Rizky Ananda. Penelitian ini menggunakan metode kualitatif. Teknik pengumpulan data yang digunakan adalah wawancara dan observasi. Hasil observasi tersebut bahwa di TK ini menggunakan 6 jenis instrumen pembelajaran, yaitu lembar observasi, lembar tugas buatan guru, catatan anekdot, portofolio, tanya jawab/percakapan, dan unjuk kerja. Penggunaan instrumen evaluasi berjalan dengan baik namun guru yang ada di TK tersebut tidak semua mampu untuk mengevaluasi pembelajaran menggunakan instrumen. Pada akhirnya, guru yang mampu menggunakan instrumen kewalahan dalam mengevaluasi pembelajaran anak usia dini.
Pengembangan Media Pembelajaran Bioptry (Bilingual Pop Up Book Geometry: Bangun Datar)
Authors: Astriani Linda , Azizah Nailah
Published: July 2023

Tujuan penelitian ini adalah untuk menciptakan media pembelajaran BIOPTRY (bilateral pop-up geometry: bangun dua dimensi) yang praktis dan valid. Penelitian ini dilatar belakangi karena belum ada media pembelajaran berbentuk pop-up book yang dikembangkan secara khusus pada pembelajaran matematik di sekolah dasar. Metodologi penelitian yang digunakan adalah R&D dengan jenis model Analisis, Desain, Developmen, Implementasi dan Evaluasi (ADDIE). Subjek penelitian adalah siswa kelas V SD Negeri 1 Cisantana, Kuningan Jawa Barat. Empat orang spesialis memvalidasi materi pembelajaran BIOPTRY diantaranya yang mengkhususkan diri pada bidang bahasa Indonesia, Inggris, materi, dan media. Tiga tahap pengujian uji coba guru, uji coba kelompok kecil, dan uji coba kelompok besar dilakukan pada pengembangan ini. Hasil uji kepraktisan guru 98% positif, uji kepraktisan kelompok kecil 95,33% positif, dan uji kepraktisan kelompok besar 89,75% positif. Hasil untuk ahli bahasa inggris 94% positif, validitas ahli materi 95% positif, dan validitas ahli media 96% positif. Menurut temuan penelitian, siswa kelas lima dapat menggunakan sumber belajar BIOPTRY dengan validitas dan kepraktisan yang tinggi.
Pengembangan Media Pembelajaran Board Game Matematika Ular Tangga untuk Siswa Tunarungu
Authors: Siregar Dilla Safera , Ananda Rusydi
Published: July 2023

Media pembelajaran merupakan bagian terpenting untuk mendukung tujuan kegiatan pembelajaran. Guru diharuskan untuk memanfaatkan media pembelajaran sebagai penyelenggara kegiatan pembelajaran. Penelitian ini bertujuan untuk mengembangkan produk yang valid, praktis, dan efektif berupa media pembelajaran board game matematika ular tangga pada materi bangun datar segiempat dan segitiga untuk siswa tunarungu. Riset yang digunakan yakni riset pengembangan dengan menggunakan model riset ADDIE. Hasil penilaian validator ahli media diperoleh 94,7% dengan kriteria sangat valid. Hasil penilaian validator ahli materi diperoleh 75,7% dengan kriteria valid, sedangkan hasil penilaian praktisi materi pembelajaran diperoleh 74,2% dengan kriteria valid. Uji coba skala kecil oleh 11 orang siswa dengan uji kepraktisan media diperoleh 94,7% dengan kriteria sangat praktis. Hal ini dibuktikan dari meningkatnya nilai pretest 38,18 menjadi 81,82 untuk nilai post-test; hasil uji normalized gain 0,6 dengan kriteria sedang dan 68,10% dengan kriteria cukup efektif. Berdasarkan hasil dan diskusi penelitian menunjukkan bahwa media pembelajaran memenuhi standar valid, praktis, dan efektif.
Analisis Implementasi Perencanaan Sarana dan Prasarana Pendidikan di MIS Nurul Fadhilah
Authors: Alfiana Kholizah Nur , Hanifah Fathia , Munawwarah Tarisa , Aulia Sani Dinda , Savitri Intan , Akmalia Rizki
Published: July 2023

In an instructive organization, offices and frameworks are important parts. Managers of educational institutions are obliged to maintain their facilities and infrastructure. Facilities and infrastructure in this case are aspects that support the success of the teaching and learning process as well as the efficiency and effectiveness of all school activities. In addition, it is important for educational institutions to provide public services to increase community response and student satisfaction. It is undeniable that the completeness of these facilities will increase parents' trust in the school, and students will also be enthusiastic in every learning process. Facilities and infrastructure can also increase the potential for student enthusiasm for learning well. Through research using subjective strategies and interview procedures, the analysts state observable facts related to the office and foundation at MIS Nurul Fadhilah where the office and framework in the school are towards the culmination and perfection of interaction for this.
The Influence of Adolescent Courtship Behavior on Social Sciences Learning Achievement in Jakarta’s Junior High School
Authors: Faiha Inayah Afifah , Safitri Desy , Sujarwo Sujarwo
Published: July 2023

This research is conducted by the many courtship behaviors of adolescents in the school environment and the dissatisfaction social sciences learning achievement. This study aims to determine whether there is influence of adolescent courtship behavior on social sciences achievement. The research method used is quantitative. Data collection techniques in this study were carried out by observation, questionnaires, and literature studies. The sample of this research was 32 respondents who were taken based on purposive sampling technique. The data processing used is simple linear regression analysis, t test, F test, and the coefficient of determination test. The results showed that the variables of courtship behavior partially and simultaneously had a negative and significant effect on the social sciences learning achievement variable. With the obtained results of the t test, t count -7.222 > t table -2.042 and sig. 0.000 < α 0.05. F count 52.152 > F table 4.15 and sig. 0.000 < α 0.05. R Square value shows a result of 63.5% indicating that the ability of the independent variable to explain the effect on the dependent variable.
Pengaruh Model Pembelajaran Quantum Writing terhadap Kemampuan Menulis Kreatif Puisi pada Siswa Kelas X SMA Negeri 1 Pedamaran Timur
Authors: Kusniati Kusniati , Misriani Misriani , Wardiah Dessy
Published: July 2023

This study aims to determine whether there is an effect of the quantum writing model on the ability to write poetry creatively in class X.1 students of SMA Negeri I Pedamaran Timur. The population in this study were all students of class X.I SMA Negeri I Pedamaran Timur, consisting of 36 students. The sample in this study was obtained using cluster random sampling technique. So that class X.1 was selected with a total of 36 students as the experimental class and X.2 with a total of 31 students as the control class. This research model uses an experimental model. The data analysis technique used is the test data analysis technique, observation interview test. The results of this study indicate that the average value of the pretest control class was not treated with quantum writing or by learning ordinary material which obtained scores of 21 and 24 while for the posttest experimental class group with quantum writing treatment 59 and a greater value of 61. This proves that there is an influence of the Quantum Writing Model on the Ability to Write Creative Poetry for Class X SMA Negeri I Pedamaran Timur. So the hypothesis in the research proved true. Based on the criteria for testing the hypothesis that HO is rejected if t count ≤ t table, and Ha is accepted if t count ≥ t table, with = 4.287 and 1.671. This proves that t count ≥ t table with a value of 4.287 ≥ 1.671 then Ha in this study is accepted as true.
Representação feminina na cena política brasileira
Authors: Reis Ruth de Cássia dos , Belisário Katia Maria
Published: July 2023

Mais de 100 anos após a instituição do primeiro Código Eleitoral brasileiro, em 1932, a sub-representação feminina na política ainda é uma realidade persistente. Dados do Tribunal Superior Eleitoral (TSE) revelam que, embora as mulheres representem 53% do eleitorado, nas eleições de 2022 elas conquistaram apenas 18% dos cargos em disputa. Essa exclusão é ainda mais acentuada entre as mulheres negras e de outras etnias, classes sociais e orientações de gênero. Os casos de abuso, assédio moral e sexual, agressões físicas, virtuais e ameaças de morte contra as mulheres são frequentes e constantes nos noticiários. Este artigo aborda as diversas formas de violência enfrentadas pelas mulheres na política, com foco nos casos que ganharam destaque na mídia durante o primeiro semestre de 2022. A metodologia utilizada inclui revisão bibliográfica e pesquisa documental, por meio de uma abordagem de bola de neve em sites jornalísticos. Os resultados revelam que a violência política tem sido uma ocorrência frequente e se intensifica à medida que a presença das mulheres nos espaços de poder avança, principalmente com o crescimento do conservadorismo, incentivando atitudes machistas e agressivas em todas as esferas da sociedade. Embora tenham sido observados alguns avanços, como a promulgação da lei que tipifica a violência política contra a mulher, é importante ressaltar que sua aplicação ainda é limitada e enfrenta desafios devido à cultura machista presente no judiciário.
Application of Chromosome Microarray in Diagnosis of Amniotic Fluid in Older Pregnant Women
Authors: Lu Guangting , Liu Weiwu , Ou Chao
Published: July 2023

Background: To improve the detection rate of chromosome abnormalities in fetuses and to reduce the birth defects rate in elderly pregnant women using chromosome karyotype analysis combined with the chromosome microarray analysis (CMA) technique. Methods: Overall, 210 elderly pregnant women with singleton pregnancies aged between 16 and 30 weeks (mean gestational age, 19.19 weeks) and 35 and 47 years (mean age, 38.08 years) were selected from January 1, 2020 to June 1, 2021 in the Eugenics Genetics Department of Yulin Maternal and Child Health Hospital. Chromosome G banding karyotype analysis and CMA detection were performed simultaneously. Results: Among the 210 elderly pregnant women with singleton pregnancies, 26 (12.38%) and 52 (24.76%) cases were detected as abnormal using chromosome karyotype analysis and CMA technology, respectively. The abnormal CMA chromosomes’ total detection rate was 12.38% higher than that using chromosome karyotype analysis (p < 0.001). CMA detected 22 pathogenic copy number variants (CNVs), 1 probable CNV, and 7 CNVs of unknown clinical significance in patients with normal karyotype analysis. Among the patients with abnormal karyotype analysis, CMA missed detection in 5 cases. Overall, 57 abnormal cases were detected when the two methods were combined, with a detection rate of 27.14% (57/210) higher than that of CMA or karyotype analysis alone. Conclusions: For the prenatal diagnosis of fetal amniotic fluid in elderly pregnant women, the combined application of chromosome karyotype analysis and CMA detection technology can further improve the detection rate of abnormal chromosomes and reduce missed diagnosis rates.
Liposomal Glutathione Supplementation Mitigates Extrapulmonary Tuberculosis in the Liver and Spleen
Authors: Sasaninia Kayvan , Kelley Melissa , Abnousian Arbi , Owens James , Yoon SonYeol , Beever Abrianna , Kachour Nala , Yegiazaryan Aram , Kolloli Afsal , Kumar Ranjeet , Ramasamy Santhamani , Subbian Selvakumar , Venketaraman Vishwanath
Published: July 2023

Background: Extrapulmonary tuberculosis (EPTB) accounts for a fifth of all Mycobacterium tuberculosis (M. tb) infections worldwide. The rise of multidrug resistance in M. tb alongside the hepatotoxicity associated with antibiotics presents challenges in managing and treating tuberculosis (TB), thereby prompting a need for new therapeutic approaches. Administration of liposomal glutathione (L-GSH) has previously been shown to lower oxidative stress, enhance a granulomatous response, and reduce the burden of M. tb in the lungs of M. tb-infected mice. However, the effects of L-GSH supplementation during active EPTB in the liver and spleen have yet to be explored. Methods: In this study, we evaluated hepatic glutathione (GSH) and malondialdehyde (MDA) levels, and the cytokine profiles of untreated and L-GSH-treated M. tb-infected wild type (WT) mice. Additionally, the hepatic and splenic M. tb burdens and tissue pathologies were also assessed. Results: L-GSH supplementation increased total hepatic levels and reduced GSH. A decrease in the levels of MDA, oxidized GSH, and interleukin (IL)-6 was also detected following L-GSH treatment. Furthermore, L-GSH supplementation was observed to increase interferon-gamma (IFN-γ) and tumor necrosis factor (TNF)-α production and decrease IL-10 levels. M. tb survival was significantly reduced in the liver and spleen following L-GSH supplementation. L-GSH treatment also provided a host-protective effect in the liver and spleen of M. tb-infected mice. Conclusions: Overall, L-GSH supplementation elevated the levels of total and reduced forms of GSH in the liver and reduced the burden of M. tb by decreasing oxidative stress, enhancing the production of immunosupportive cytokines, and reducing the levels of immunosuppressive cytokines. These observed benefits highlight the potential of L-GSH supplementation during active EPTB and provide insight into novel therapeutic interventions against M. tb infections.
Bioconversion of Crop Residues Using Alternative Fermentation-Based Approaches
Authors: Verardi Alessandra , Sangiorgio Paola , Blasi Alessandro , Lopresto Catia Giovanna , Calabrò Vincenza
Published: July 2023

Globally, the growing production of food commodities generates significant quantities of agroindustrial residues, most of which are untreated and disposed of as waste through either burning, dumping into the land, or unplanned landfilling, thereby causing environmental pollution, public health problems, and decreased soil organic matter and soil productivity. A literature review has been conducted on the current crop residue biomass valorization, analyzing raw material properties and the potential risks associated with its incorrect or absent management, as well as the major microbial fermentation strategies that are used for converting residual crops into valuable products. Approximately 2445.2 million tons of crop residues are produced worldwide. Microbial fermentation is an efficient way of managing residues that are rich in nutrients (e.g., nitrogen, phosphorus, and potassium) and converting them into single-cell proteins, antibiotics, enzymes, bioalcohols, polysaccharides, fine chemicals, and others, thereby supporting a circular bioeconomy. Although separate saccharification and fermentation (SHF) represent the predominant fermentation strategy, it requires considerable equipment costs and a long process time, which can lead to the formation of contaminations and inhibitors. Alternative conversion strategies, including simultaneous saccharification and fermentation (SSF), simultaneous saccharification and co-fermentation (SSCF), and consolidated bioprocessing (CBP), can reduce time and production costs, contaminations, and inhibitor formation, and enhance process yields. Nevertheless, combining hydrolysis and fermentation into a single phase results in non-optimal temperature and pH. This review discusses crop residue valorization through fermentation strategies, and provides a 360-degree view of the topic. After investigating the major types of crop residues and the potential environmental risks associated with their incorrect or absent management, it analyzes the key steps in the crop residue bioconversion process, and the most common microorganisms and microbial cultures. In addition, this review reports on various examples of crop residues being converted into industrial products and analyzes the main fermentation strategies (SHF, SSF, SSCF, and CBP), highlighting their strengths and weaknesses. As a matter of fact, fermentation strategies need to be compared for their benefits and disadvantages before being implemented on a large scale. In addition, the properties and availability of the raw materials, investment, and operating costs, the skilled workforce availability, sustainability, and the return on investment all need to be evaluated. Finally, the discussion focus on future outlooks and challenges.
A Potential Autophagy-Related-Gene Based Signature in Patients with Preeclampsia
Authors: Shen Jiayu , Teng Xinyuan , Zhao Jiayao , Feng Yuanling , Wang Liquan
Published: July 2023

Objective: Preeclampsia (PE) is a significant cause of maternal and offspring mortality and morbidity. The purpose of this study is to identify the potential diagnostic signatures of autophagy-related genes (ATGs) in pregnancies with preeclampsia. Methods: The expression profile of mRNA was obtained from GSE75010 (placenta samples) and GSE48424 dataset (blood samples). The potential differentially expressed ATGs of PE were screened by R software. The gene-ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, correlation analysis, and protein-protein interactions (PPI) were applied for the differentially expressed ATGs. The diagnostic markers of PE were then screened based on least absolute shrinkage and selection operator (LASSO) logistic regression and support vector machine-recursive feature elimination (SVM-RFE). Receiver operating characteristic (ROC) analysis was used to investigate the predictive value of these diagnostic markers. Target miRNAs were predicted based on the miRDB, DIANA-micro T, Targetscan, and miRWalk databases, and were further validated in GSE84260. Results: A total of 20 differentially expressed ATGs were identified between PE and healthy pregnancies. Functional analysis of differentially expressed ATGs indicated several enriched terms related to autophagy, apoptosis, angiogenesis, inflammation, immune response, hypoxia-inducible factor 1 (HIF-1), forkhead box O (FoxO) and AMP-activated protein kinase (AMPK) signaling pathway. A total of 12 ATGs were recognized based on LASSO and SVM-RFE, which made an excellent distinction in both the placenta tissues (area under the curve [AUC] = 0.903) and the blood samples (AUC = 0.972). Furthermore, four feature ATGs (leptin [LEP], ERO1-like [ERO1L], phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [PIK3CB], and mitogen-activated protein kinase 8 [MAPK8]) were screened and also shown an excellent diagnostic efficacy (AUC = 0.869 in placenta samples, and AUC = 0.914 in blood samples). Additionally, 81 target miRNAs were predicted according to the 4 feature ATGs. After evaluating the miRNA expression pattern of GSE84260, 11 miRNAs were selected. Finally, a miRNA-mRNA regulatory network was constructed, which may participate in the development of PE. Conclusions: We established an autophagy-related-gene based signature that may predict pregnancies with PE. And we also constructed a miRNA-mRNA regulatory network, which may deepen our understanding of the molecular mechanism underlying the development of PE.
SGLT-2 Inhibitors for Non-Alcoholic Fatty Liver Disease: A Review
Authors: Xu Rong , Lian Difei , Xie Yan , Chen Zhilei , Wang Yan , Mu Lin , Wang Yuan , Zhang Baoyu
Published: July 2023

Non-alcoholic fatty liver disease (NAFLD) is a group of metabolic liver illnesses that lead to accumulation of liver fat mainly due to excessive nutrition. It is closely related to insulin resistance, obesity, type 2 diabetes, and cardiovascular disease, and has become one of the main causes of chronic liver disease worldwide. At present, there is no specific drug for the treatment of NAFLD; lifestyle interventions including dietary control and exercise are recommended as routine treatments. As a drug for the treatment of type 2 diabetes, sodium-glucose co-transporter type 2 (SGLT-2) inhibitors may also play a beneficial role in the treatment of NAFLD. This article reviews the mechanism of SGLT-2 inhibitors in the treatment of NAFLD.
Correlation between Obstructive Sleep Apnea Syndrome (OSAS) and Cognitive Dysfunction in Elderly Patients with Hypertension
Authors: Xia Wei , Jing Yongle , Yuan Chao
Published: July 2023

Introduction: Obstructive sleep apnea syndrome (OSAS) is a common clinical disease that seriously affects the quality of life and health of patients. This study aimed to explore the correlation between OSAS and cognitive dysfunction in elderly patients with hypertension. Methods: A total of 106 elderly hypertensive patients were included and divided into OSAS group (n = 45) and non-OSAS group (n = 61), according to whether they combined with OSAS. OSAS was monitored with a portable polysomnography monitor by monitoring sleep and breathing. The cognitive dysfunction of the patients was evaluated using the Montreal Cognitive Assessment (MoCA). Basic data and MoCA scores of the patients were compared between the OSAS group and non-OSAS group. The correlation between OSAS and cognitive dysfunction in patients was evaluated using Pearson’s correlation analysis. Results: The proportion of men (38 vs. 22, p = 0.000), atrial fibrillation (31 vs. 19, p = 0.000), body mass index (27.32 ± 3.85 vs. 21.27 ± 5.90, p = 0.002), systolic pressure (167.76 ± 14.31 vs. 153.22 ± 12.79, p = 0.008), homocysteine (29.71 ± 6.27 vs. 12.50 ± 4.19, p = 0.005), cognitive dysfunction (15 vs. 10, p = 0.042) in patients of the OSAS group were significantly higher compared to patients of the non-OSAS group. Visual space/executive ability (3.12 ± 1.23 vs. 4.75 ± 1.03, p = 0.021), memory (2.48 ± 0.31 vs. 3.71 ± 0.42, p = 0.039), attention (4.15 ± 1.21 vs. 5.12 ± 1.87, p = 0.041), total MoCA scores (20.11 ± 5.09 vs. 25.76 ± 4.31, p = 0.017) in patients in the OSAS group were significantly lower compared to patients in the non-OSAS group. OSAS was positively correlated with cognitive dysfunction in elderly patients with hypertension (r = 0.224, p < 0.05). Conclusions: OSAS was positively correlated with cognitive dysfunction in elderly patients with hypertension, so OSAS could increase the risk of cognitive dysfunction through its own adverse effects or its accompanying disease status.
The Role of Mitochondrial Biogenesis in Ischemic Stroke
Authors: Shademan Behrouz , Avci Cigir Biray , Karamad Vahidreza , Soureh Gholamreza Jahangirzadeh , Olia Jalhe Bagheri Hamzyan , Esmaily Farzaneh , Nourazarian Alireza , Nikanfar Masoud
Published: July 2023

Ischaemic stroke is a sudden neurological disorder caused by localised cerebral ischaemia and persistent cerebral infarction. Occlusion of large arteries due to atherothrombosis, cerebral embolism (i.e., embolic infarction), no thrombotic occlusion in small, deep cerebral arteries (i.e., lacunar infarction), and stenosis of proximal arteries due to hypotension leading to decreased cerebral blood flow in arterial supply zones are the most common causes of ischemic stroke (i.e., hemodynamic stroke). It is now known that organelles play an important role in various signaling events and cellular functions. The molecular mechanisms of mitochondria are involved in cerebral ischemia by generating and scavenging reactive oxygen species, apoptosis, biogenesis, mitochondrial dynamics, and inflammation are all examples of electron transport chain dysfunction. More knowledge about the involvement of mitochondria in ischemia-induced neuronal death and neuronal protection will contribute to the development of better treatment programs for stroke syndromes such as ischemic stroke.
The Effect of Equine-Assisted Activities in Children Aged 7–8 Years Inhibitory Control: An fNIRS Study
Authors: Cheng XiaoDong , Qian Lei , Fan Yongzhao , Tang Qian , Wu Hao
Published: July 2023

Background: Inhibitory control (IC), an important component of executive function, plays an important role in the overall development of children and has not been better studied in the field of equine-assisted activity (EAA). Therefore, this study investigated the effects of EAA on IC and the underlying brain neural mechanisms in children aged 7–8 years. Methods: Forty-eight healthy children aged 7–8 years from the Maple Leaf International School-Xi’an were randomly allocated to the equine-assisted activities group (EAAG) and control group (CG). The EAAG received 12 weeks of EAAG training from instructors at the MingLiu Horse Club while the CG continued their normal daily activities. The Flanker task was administered to both groups to assess IC pre- and post-intervention. Functional near-infrared spectroscopy (fNIRS) data were collected during the Flanker task to examine the underlying neural mechanisms. Results: Our findings indicate that after 12 weeks of EAA, the EAAG performed significantly better on the Flanker tasks than the CG, with congruent and incongruent higher accuracy and faster reaction (p < 0.01). Importantly, fNIRS data analysis revealed increased oxyhemoglobin levels in the right dorsolateral prefrontal cortex (R-DLPFC) (p < 0.05) of the EAAG during the Flanker congruent task after the EAA intervention. Conclusions: Collectively, EAA demonstrated a positive impact on IC and could effectively activate R-DLPFC in children aged 7–8 years. Furthermore, it enhanced the activation of the brain regions related to IC and increased cognitive ability in children aged 7–8 years.
Blood Biomarkers for Prediction of Positive CT Findings in Mild Traumatic Brain Injury in Paediatric Population
Authors: Siempis Timoleon , Georgalis Pavlos A , Lianos Georgios , Kafritsas Georgios , Metaxas Dimitrios , Alexiou Eleutherios-Spyridon , Zika Jiolanda , Sotiropoulos Athanasios , Alexiou George A , Voulgaris Spyridon
Published: July 2023

Background: Paediatric Traumatic Brain Injury (TBI) has received less research attention compared to TBI in adults, despite its potential morbidity in all ages. Our aim was to determine whether neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and glucose levels at admission can reliably predict the need for imaging in children presenting with mild TBI. Methods: We retrospectively reviewed the clinical records of paediatric patients who presented in the emergency department with mild TBI within a 5 year period and had undergone computed tomography (CT) scan of the head. Results: Overall, 43 eligible patients were included in the study, with falls being the most commonly reported cause of injury. Twenty-three children had positive CT findings. Patients with abnormal CT findings were found to have higher NLR ratios compated with patients with normal CT, with the mean NLR on admission being 5.2 ± 3.8. Children with abnormal CT findings had lower PLR levels and higher glucose levels at presentation compared to children with normal CT, however the differences were not statistically significant. Using the receiver operating characteristic (ROC) curve, we found that a NLR cut off value of 6.1 yielded a sensitivity of 54.2% and a specificity of 89.5% for the prediction of abnormal CT findings. Conclusions: The findings of this study suggest that NLR may have a role in CT decision-making in the emergency department for mild TBI in paediatric patients.
Probiotics Improve Cognitive Impairment by Decreasing Bacteria-Related Pattern Recognition Receptor-Mediated Inflammation in the Gut-Brain Axis of Mice
Authors: Yang Xue-Qin , Zhao Yang , Xue Li , Wang Hui-Shan , Zeng Jia , Du Jun-Rong , Xu Zhe
Published: July 2023

Introduction: Some studies have found that probiotics can improve cognitive impairment in Alzheimer’s disease, although the specific molecular mechanism by which this occurs has not been reported. Our previous research found that probiotics inhibited bacteria-related Toll-like receptor 4- and retinoic-acid-inducible gene-I-mediated nuclear factor-κB signaling pathways to improve cognitive impairment. However, it is unclear whether probiotics have similar effects on other pattern recognition receptors that respond to bacteria. Methods: Nine-month-old senescence-accelerated mouse prone 8 (SAMP8) mice received ProBiotic-4 (a mixture of Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus casei, and Bifidobacterium lactis) orally for 12 weeks. The effects on other bacteria-related pattern recognition receptors were then investigated. Results: ProBiotic-4-treated SAMP8 mice showed improvement in memory deficits, synaptic and cerebral neuronal injuries, and microglial activation. ProBiotic-4 also markedly increased the expression of intestinal tight junction proteins (i.e., claudin-1, occludin, and zonula occluden-1), decreased the expression of interleukin-1β at both the mRNA and protein levels, and reduced the expression of caspase-11, cleaved caspase-1, and α-kinase 1 (ALPK1) in the intestine and brain. Conclusions: These findings suggest that probiotics may have therapeutic potential for the treatment of inflammation in the gut-brain axis and for cognitive impairment. The mechanism of action of probiotics appears to be related to inhibition of the caspase-11/caspase-1 pathway and reduction of ALPK1 expression.
High-Sensitive Cardiospecific Troponins: The Role of Gender-Specific Concentration in the Diagnosis of Acute Coronary Syndrome (Descriptive Review)
Authors: Chaulin Aleksey
Published: July 2023

Cardiospecific troponins are specifically localized in the troponin-tropomyosin complex and in the cytoplasm of cardiac myocytes. Cardiospecific troponin molecules are released from cardiac myocytes upon their death (irreversible damage in acute coronary syndrome) or reversible damage to cardiac myocytes, for example, during physical exertion or the influence of stress factors. Modern high-sensitive immunochemical methods for detecting cardiospecific troponins T and I are extremely sensitive to minimal reversible damage to cardiac myocytes. This makes it possible to detect damage to cardiac myocytes in the early stages of the pathogenesis of many extra-cardiac and cardiovascular diseases, including acute coronary syndrome. So, in 2021, the European Society of Cardiology approved diagnostic algorithms of acute coronary syndrome, which allow the diagnosis of acute coronary syndrome in the first 1–2 hours from the moment of admission of the patient to the emergency department. However, high-sensitive immunochemical methods for detecting cardiospecific troponins T and I may also be sensitive to physiological and biological factors, which are important to consider in order to establish a diagnostic threshold (99 percentile). One of the important biological factors that affects the 99 percentile levels of cardiospecific troponins T and I are gender characteristics. This article examines the role of gender-specific concentration of cardiospecific troponins in the diagnosis of acute coronary syndrome and the mechanisms of formation of gender-specific serum levels of cardiospecific troponins T and I.
The Embodiment of Mahakrya Lango Film
Authors: Payuyasa I Nyoman , Lia Susanthi Nyoman , Hari Kayana Putra I B.
Published: July 2023

The Indonesian Institute of the Arts Denpasar (ISI Denpasar) is an arts college in Bali that is established based on the values of local wisdom and national insight in order to enrich human values. ISI Denpasar seeks to strengthen media literacy to campaign for the heritage of cultural arts values through audio-visual media to the public. In order to support the presence of this audio-visual media, the author conducted research and created a short film with the title Mahakrya Lango. Mahakrya Lango is a short film that is strengthened by a poetic narrative. In short, this film covers the journey of Balinese art and culture, the hustle and bustle of Bali, the oblivion of heritage, to the presence of ISI Denpasar as an art and cultural advisory institution. In its embodiment, this film takes several main visuals with a water background set as a symbol of the source of life, flexibility, dynamism, firmness, to fragility. The film creation method uses three stages, namely pre-production, production, and post-production. In the embodiment of the Mahakrya Lango film, the location set is Tamblingan Lake to visualize water as a source of life, waterfalls to symbolize flexibility and dynamism, and beach locations to depict celebrations.
Seni Penerjemahan Wayang Inovasi Berbahasa Inggris Di Swasti Eco Cottages, Ubud, Gianyar
Authors: Tisna Andayani Ni Putu
Published: July 2023

Perkembangan seni pertunjukan wayang telah berinovasi menggunakan bahasa Inggris dengan tujuan untuk menghibur wisatawan mancanegara yang datang ke Bali. Pertunjukan wayang turistik ini mulai bermunculan di daerah-daerah wisata dan sekitarnya. Berikut ini permasalahan dan ideologi penerjemahan wayang turistik berbahasa Inggris di Swasti Eco Cottages, Desa Nyuh Kuning, Ubud, Gianyar diidentifikasi, ditranskripsi dan diteliti berlandaskan pada kajian studi linguistik terapan. Untuk dapat mengidentifikasi permasalahan penerjemahan pertunjukan wayang inovasi berbahasa Inggris di Swasti Eco Cottages tersebut, peneliti menggunakan metode penilitian deskriptif kualitatif dan teknik wawancara terpusat. Permasalahan penerjemahan wayang inovasi berbahasa Inggris kemudian dikaji secara obyektif dan subyektif, sedangkan ideologi penerjemahannya diidentifikasi melalui teori domestikasi dan foreignisasi. Hasil penelitian tersebut menunjukkan bahwa penerjemahan wayang inovasi berbahasa Inggris di Swasti Eco Cottages lebih cenderung menggunakan ideologi penerjemahan foreignisasi, yakni penerjemahan yang lebih berorientasi pada bahasa sumber.The development of the art of puppet show has been innovating into English language that aimed to entertain the international visitors who come to Bali. This touristic puppet show began to appear in tourism and surrounding areas. The following issues and the translation ideology of the English touristic puppets at Swasti Eco Cottages, Nyuh Kuning village, Ubud, Gianyar identified, transcribed and studied based on the study of applied linguistics studies. In order to identify the translation problems in English language innovation puppet show at Swasti Eco Cottages, researchers used the qualitative descriptive research methods and centered interview techniques. The translation problems in English innovation puppet show then assessed objectively and subjectively, whereas the ideology of translation identified through domestication and foreignization theories. Research results indicate that the English language translations of innovations puppet show at Swasti Eco Cottages preferred to use foreignization ideology of translation, that the translations is more oriented to the source language.
Kartun Sebagai Elemen Visual Media Pembelajaran Lalu Lintas Ditlantas Polda Bali
Authors: Artawan Cokorda Alit , Astuti Ni Ketut Rini
Published: July 2023

Usaha baru yang dilaksanakan Ditlantas Polda Bali untuk mengurangi angka kecelakaan lalu lintas dengan mengeluarkan media pembelajaran lalu lintas dengan elemen visual kartun. Mengingat kebanyakan korban kecelakaan lalu lintas berasal dari kalangan generasi muda, Maka gaya kartun dipandang tepat karena sangat popular dikalangan generasi muda. Penelitian ini bertujuan untuk mengidentifikasi gaya kartun, pesan yang terkandung, dan untuk mengetahui elemen kartun yang telah digunakan oleh Ditlantas Polda Bali. Penelitian ini menggunakan metode deskriptif kualitatif dan kuantitatif dengan menyebarkan kuisioner. Analisis data kuisioner yang diberikan pada responden menggunakan acuan tinggi rendah nilai prosentase dan kolerasi terhadap pertanyaan yang diberikan untuk memberi gambaran data hasil pilihan responden. Populasi dalam penelitian ini adalah Media pembelajaran lalu lintas Ditlantas polda Bali yang berada di sepanjang perempatan Tohpati sampai Jl WR supratman menuju depan Polda Bali. Hasil yang diperoleh, kartun sangat tepat digunakan sebagai elemen visual mengingat dengan visualisasi dan kandungan humornya kartun sangat menarik dan mampu menyampaikan informasi secara efektif pada khalayak sasarannya.Â The new venture undertaken Ditlantas Polda Bali is to reduce the number of traffic accidents by publishing a traffic learning media with the visual elements of the cartoon. Given the plethora of traffic accident victims from among the younger generation, so the style of cartoons deemed appropriate because it is very popular among the younger generation. This study aims to identify the style of the cartoon, the message contained, and to know the elements of the cartoons that have been used by the Ditlantas Polda Bali. This study uses qualitative and quantitative descriptive by distributing questionnaires. The data analysis of a questionnaire given to respondents using low high reference value and the percentage of correlation to the questions given to illustrate the data chosen by the respondent. Population in this research is the learning media of traffic which using by Ditlantas Polda Bali located along the intersection of Jl WR Supratman Tohpati up toward the front of the Polda Bali Office. The results obtained, the cartoon is ideal to use as a visual element to remember with visualization and content of the cartoon humor is very attractive and able to convey information effectively to the target audience.
Ungkapan Estetis Sistem Konstruksi Pada Interior Bangunan Tradisional Bali
Authors: Padmanaba Cok Gd Rai , Artadi Made Pande , Tiaga Nyoman Adi
Published: July 2023

Keindahan bangunan tradisional Bali bisa dijumpai pada berbagai elemen, termasuk pada bagian yang berperan sebagai konstruksi, walaupun konstuksi sering dikonotasikan pada sesuatu yang kaku dan kokoh. Tujuan penelitian ini adalah untuk mencermati lebih jauh sistem konstruksi pada interior bangunan tradisional Bali, dan bagaimana konstruksi tersebut dikemas dalam suatu ungkapan estetis yang bisa memperindah interiornya. Metode yang diterapkan dalam penelitian ini adalah metode deskriptif kualitatif tentang ragam hias dan filosofi penempatannya dengan penelahaan literatur, wawancara dengan para arsitek bangunan tradisional Bali, serta pengamatan langsung terhadap beberapa bangunan tradisional Bali, yang tersebar dibeberapa daerah kabupaten dan kota di Bali. Analisis yang dilakukan berupa analisis kualitatif yang berupa penilaian terhadap unsur-unsur keindahan yang tidak bisa disampaikan berupa angka-angka yang terukur. Penelitian akan difokuskan dengan penelusuran lebih mendetail pada bale dangin, khususnya mengenai jenis jenis ragam hias yang diterapkan, dan bagaimana filosofi penempatan ragam hias tersebut. Hasil penelitian menunjukkan bahwa ragam hias yang diterapkan pada interior didominasi dari bentuk-bentuk pepatran yang disertai bentuk kekarangan dan patung. Filosofi penempatan ragam hias sampai saat ini belum didapatkan sehingga jenis ragam hias menjadi sangat berkembang sesuai dengan kreasi dari pemilik bangunan, tanpa meninggalkan nilai-nilai keagamaan.The beauty of Bali traditional buildings can be found on a variety of elements, including the part that acts as the construction, although construction purposes often connotes something rigid and sturdy. The purpose of this study was to further examine the interior construction systems in traditional Balinese buildings, and how construction is packaged in an aesthetic expression that can beautify the interior. The method applied in this research is descriptive qualitative method of decoration and philosophy placement with review of the literature, interviews with architects of Bali traditional buildings, as well as direct observation of some Bali traditional buildings, which are scattered in several regencies and municipalities in Bali. Analysis was done by qualitative analysis in the form of an assessment of the elements of beauty that can not be delivered in the form of measurable figures. Research will be focused in greater detail on a bale dangin, particularly concerning the types of decoration that is applied, and how the philosophy of the decorative placement. The results showed that the decoration is applied to the interior is dominated forms accompanied pepatran, kekarangan and sculpture. Philosophy placement of decorative until now has not found that the type of decoration to be highly developed in accordance with the creation of the owner of the building, leaving no religious values.
Tipe Kesalahan Berbahasa Dalam Skripsi Mahasiswa Institut Seni Indonesia Denpasar
Authors: Adipurwa A.A. Trisna Ardanari , Haryati Ni Made
Published: July 2023

Tujuan dari penelitian ini adalah untuk mencatat dan mengklasifikasikan kesalahan berbahasa dalam skripsi mahasiswa ISI Denpasar berdasarkan tipe kesalahan berbahasa. Kemudian, data tersebut dianalisis untuk diketahui penyebab-penyebabnya. Penelitian ini merupakan penelitian deskriptif kualitatif. Sumber data diperoleh melalui metode simple random sample dengan teknik pengambilan data yaitu dokumentasi dan teknik catat. Hasil penelitian ini mencakup dua hal.Â  Pertama, kesalahan berbahasa yang ada dalam skripsi mahasiswa ISI Denpasar dikelompokkan menjadi empat tipe yaitu 1) kesalahan ejaan, 2) kesalahan morfologi, 3) kesalahan sintaksis, dan 4) kesalahan paragraf. Kedua, penyebab kesalaahan berbahasa dari masing-masing tipe (ejaan, morfologi, kalimat, dan paragraf) tersebut adalah ketidakcermatan, interfensi, dan ketidakpahaman pemakai bahasa mengenai kaidah berbahasa.The purpose of this research is to record and classify the mistake of language in student's thesis ISI Denpasar based on error type of language. Then, the data is analyzed for known causes. This research is a qualitative descriptive research. Source of data obtained through simple random sample method with data retrieval technique that is documentation and technique note. The results of this study include two things. First, the existing language errors in the ISI Denpasar student's thesis are grouped into four types: 1) spelling mistakes, 2) morphological errors, 3) syntactic errors, and 4) paragraph errors. Second, the causes of language abnormalities of each type (spelling, morphology, sentences, and paragraphs) are the language's inadequacy, interference, and misunderstanding of the language rules.
Kajian Semiotika Sebagai Strategi Komunikasi Pada Film Enslaved
Authors: Yogi Antari Tirta Yasa Desak Putu
Published: July 2023

Semiotika film merupakan salah satu bidang utama dalam teori film yang penting untuk dipahami sebagai sebuah paradigma dalam proses pengkajian dan penciptaan film. Perlu adanya suatu kajian yang mengkhusus mengenai semiotika film, salah satunya adalah dengan mengkaji film yang menerapkan semiotika film sebagai strategi komunikasi. Enslaved merupakan film produksi Yayasan Seva Bhuana dan Sanggar Sri Redjeki Films yang menarik untuk dikaji karena menggunakan semiotika sebagai strategi komunikasinya. Metode yang akan dipakai dalam penelitian ini adalah metode kualitatif, yang dilakukan dengan penentuan subyek penelitian, objek penelitian, lokasi penelitian, desain penelitian, penentuan informan, metode pengumpulan data dan metode analisis data. Metode analisis data yang digunakan dalam penelitian ini adalah metode semiotika yang bersifat kualitatif-interpretatif dan metode semiotika empiris, dengan penyajian hasil analisis data dengan metode deskriptif analitif. Hasil penelitian ini adalah kajian mengenai penerapan teori semiotika film dalam Enslaved serta penerapan unsur-unsur semiotika terkait dengan unsur-unsur film.Film semiotics is one of the main field on film theory which is important to understand as a paradigm in the process of film study and creation. A specific study about film semotics is needed, one of it by reviewing film that apply film semiotics as communication strategy. Enslaved is a film by Yayasan Seva Bhuana and Sanggar Sri Redjeki Films which is interesting to be studied because it applied film semiotics as communication strategy. The method used in this research is qualitative method by the determination of research subject, research object, research location, research design, informants, methods of collecting data and methods of data processing. The analysis methods used in this research is semiotics methods which is qualitative-interpretative and empiric semiotics methods with descriptive-analitive methods on data presentation. The result of this research is a study of the application of film semiotics theory and how semiotics elements related to the film elements in Enslaved.
Kampanye Sosial Memilah dan Mengolah Sampah Organik maupun Anorganik di Dusun Pucukan
Authors: Solicitor C.R.E.C Aileena , Putra Danang Mahardika , Huwaidaa Hapsari Ronaa , Dewi Mitha Karima , Rahmanzah Gita Ady , Adiguna P Aswin , Fathqurrahman J Faisal
Published: July 2023

Permasalah lingkungan yang terdapat di Dusun Pucukan merupakan masalah yang kompleks. Masalah ini adalah masalah sampah. Kondisi geografis yang menyebabkan kurangnya tempat pembuangan sampah menjadi salah satu penyebab sampah menumpuk dan tersebar, apalagi kesadaran warga dan pengetahuan dalam mengelola sampah juga kurang. Jika masalah ini tidak segera diselesaikan, masalah sampah ini dapat menyebabkan masalah lain seperti masalah kesehatan. Kampanye sosial ini dilakukan berdasarkan riset dengan metode kualitatif dan kuantitatif berupa kuesioner, observasi, dan wawancara mendalam, sehingga ditemukan data bahwa Dusun Pucukan membutuhkan tempat sampah. Tetapi pembuatan tempat sampah saja tidak cukup, sampah perlu dipilah-pilah berdasarkan jenisnya. Dengan membuat gerakan â€œMilah Milihâ€ memudahkan warga dalam mengidentifikasi dan mengklasifikasikan sampah anorganik dan organik, sehingga akan memudahkan warga dalam mengolah sampah.