bluuebunny/crossref_metadata_2025 huggingface dataset:
Per un compleanno speciale. Omaggio ad Anna Maria Compagna
Authors: Ripa Valentina , Puigdevall Núria
Published: June 2022

Presentació del monogràfic.
Ovidi enamorat de Bernat Metge, de la descriptio puellae a la serenor de l’amor madur. Traducció a l’espanyol i anàlisi d’unitats fraseològiques [UF]
Authors: Martines Peres Vicent
Published: June 2022

Resum: Aquest estudi proposa un escandall de traducción a l’espanyol de l’obra “menor” [‘breu’] de Bernat Metge, Ovidi enamorat. Hom fa una anàlisi del contrast que s’hi estableix entre la descriptio puellae i la passió amorosa jovenívola i la serenor de l’amor madur, que ha superat el temps i les dificultats. S’hi analitza també les unitats fraseològiques de l’original en haver-les de traducir de manera que no es desvirtue la textura del llenguatge literari de l’original.Paraules clau: Ovidi enamorat, Bernat Metge, descriptio puellae, amor madur, unitats fraseològiques, traducció a l’espanyol, HumanismeAbstract: This study focusses on a (draft of) translation into Spanish ot the “minor” [´short’] novel by Bernat Metge: Ovidi enamorat [Ovid in Love]. The contrast between, in one hand, the description puellae and the young love passion that it excites, and, by the other hand, the serenity of the “mature love” which has passed time and difficulties. This study analyses as well the Phraseological Units form the original when the are translated into Spanish in order to not to loose its original literary language character.Keywords: Ovid in Love, Bernat Metge, Descriptio Puellae, Mature Love, Phraseological Units, Translation into Spanish, Humanism
Leggere o interpretare Ausiàs March
Authors: Grilli Giuseppe
Published: June 2022

Riassunto: Si legge March in parallelismo con Carner, guidati dalla ossessione novecentista per la poesia pura o d’intelletto. Guidati, entrambi? Sì, perché March nel distinguere tra poesia di teatralità e poesia egotista per miracolo realizza una modernità che tarderà secoli e farsi intellegibile. E in tal senso spezza ogni plausibilità della cronologia come in un suo scritto duplice, romanzo e libretto d’opera, ha fatto in anni recenti Yehoshua.Parole chiave: Ausiàs March, Josep Carner, poesia narrativa, poesia dell’ioAbstract: We read March in parallel with Carner, driven by the twentieth-century obsession with pure or intellectual poetry. Guided, both of them? Yes, because March in distinguishing between poetry of theatricality and egotistical poetry by miracle achieves a modernity that will take centuries to become intelligible. And in this sense he breaks all plausibility of chronology, as Yehoshua has done in recent years in a double piece of writing, a novel and an opera libretto.Keywords: Ausiàs March, Josep Carner, narrative poetry, poetry of the self
Ressenya a Anton M. Espadaler: Jaufré, Barcelona: Barcino, 2021
Authors: Mompó Navarro Jacob
Published: June 2022

Ressenya a Anton M. Espadaler: Jaufré, Barcelona: Barcino, 2021, 783 pp. ISBN 978-84-7226-869-2Review to Anton M. Espadaler: Jaufré, Barcelona: Barcino, 2021, 783 pp. ISBN 978-84-7226-869-2
El amparo de tierras: la acción, el proceso y el juez de restitución
Authors: Quinche Ramírez Manuel Fernando , Peña Huertas Rocío del Pilar , Parada Hernández María Mónica , Ruiz González Luis Henrique , Ricardo Álvarez Morales
Published: June 2022

Esta obra es resultado de una revisión de los fallos de restitución proferidos desde el último trimestre del 2012 hasta las últimas que fueron publicadas del año 2014, que se hicieron públicos a través de los sitios de internet de la Unidad de Restitución de Tierras y del Consejo Superior de la Judicatura. Todos los fallos fueron organizados y sistematizados en una matriz que permitiera identificar los hechos principales expuestos en cada fallo, los asuntos que serían desarrollados en el mismo y los problemas jurídicos que abordó cada uno. El libro se desarrolla de la siguiente manera: en el primer capítulo se enmarca la tesis que se defiende, es decir, que los jueces de restitución son jueces constitucionales y pueden de acuerdo con López construir precedente horizontal. En el capítulo 2 se abordarán las decisiones judiciales sobre acumulación de procesos a la restitución de tierras. Luego, se tratará el tema de la titulación conyugal en el marco de los fallos de restitución. En el capítulo 4 nos referimos a las decisiones relevantes sobre la aplicación del enfoque diferencial en el proceso de restitución. Posteriormente se analizará la cuestión de la buena fe exenta de culpa y los opositores en las sentencias de restitución. En seguida, en el capítulo 6 se abordarán los fallos de restitución relevantes sobre el tema de la adjudicación de baldíos a través del proceso de restitución. Muy relacionado con este tema, en el siguiente capítulo se trata la relación de la restitución de tierras con la Unidad Agrícola Familiar (UAF) como figura particular de la legislación agraria. A continuación, en el capítulo 8 se analizarán las decisiones judiciales más relevantes sobre la restitución en Zonas de Reserva Forestal (ZRF). Finalmente el capítulo 9 se encargará de analizar los procesos de restitución en las zonas en las que hay labores de exploración y explotación de recursos minero-energéticos.
A Narrative Review of Anatomy and Clinical Biopsychosocial Assessment of Sacroiliac Joint Pain
Authors: Sharma Nidhi Suresh , Chitapure Tajuddin Burhanuddin , Bhalerao Anuja Atul
Published: June 2022

Sacroiliac Joint (SIJ) pain is a severe disorder that affects 15% to 25% of individuals having axially low back pain. The most common causes of depressive symptoms are fear of movement, pain catastrophising, stress, and nervous system sensitisation. Recent research has shown that radiological imaging, are inadequate for diagnosing SIJ pain. For immersive and patient centred experiences, a comprehensive professional Biopsychosocial (BPS) physiotherapy evaluation is suggested. A new biopsychosocial model has been proposed that acknowledges all critical health and disease factors and promotes the interaction of biological, psychological, and social influences, but moves further than a narrow perspective. Psychosocial influences on well-being have generated an interest in physician services, physiotherapy evaluation, and implementation in a more systematic approach to a patient. This method is used to determine the current pain mechanism (predominant nociceptive, neuropathic, or non neuropathic central sensitisation pain) as well as the underlying pain mechanism. Patient’s biopsychosocial variables can establish and maintain SI discomfort. For a better plan of therapy to manage SIJ dysfunction, the biopsychosocial clinical assessment takes precedence over the examination of sacroiliac joint discomfort alone.
Impact Level of Knowledge and Constraints Faced by the Farmer Producer Organization on Farmers Income in Kurnool District of Andhra Pradesh
Authors: Prasanna S. Keerthi , Mazhar Syed H.
Published: June 2022

The present study was conducted in Kurnool district of Andhra Pradesh, from Kurnool district Bethamcherla mandal was selected purposively based on considerable number of respondents as a member of Farmer Producer Organization. There are 174 FPO groups in Bethamcherla Mandal. From one mandal 6 villages were selected randomly based on the considerable number of members of Farmer Producer Organization. From each selected village farmers were selected randomly. In this way a total of 120 farmers were considered as respondent for the present study. Out of 120 farmers 60 are selected for beneficiaries and 60 for non beneficiaries. These selections were done by using simple random sampling method for the purpose of the study. where as in beneficiaries majority of the farmers are having a full of knowledge about organization, and having a partial knowledge on the activities and processing unit that are undergoing in FPO where as in non beneficiaries majority of the farmers having a full of   knowledge on how many members should be there in an organization and having partial knowledge on shares they receive in an year. Most of the respondents have given their feedback that they are facing lack of well developed storage facilities, processing facilities, lack of technical skill of labourers in harvesting ,processing etc., The major suggestions that are given by the respondents are efficient supply of inputs, Processing, storage and transport facilities, Enhance government support etc.
Response of Different Pre-Sowing Seed Treatments with Biofertilizers, Biostimulants and Botanicals on Growth, Yield and Yield Attributing Traits in Chickpea (Cicer arietinum L.) var. Desi Himmat
Authors: Praveen Gandasiri , Bara Bineeta M. , Lal Gaibriyal M. , Pal Abishek Kumar
Published: June 2022

Legumes are the richest protein sources of human diet, livestock of people in poor areas, green fodder to animals and are also used as green manure crops. The present study entitled, “Response of different pre- sowing seed treatments with Biofertilizers, Biostimulants and Botanicals on growth, yield and yield attributing traits in chickpea (Cicer arietinum L.) var. desi himmat”, was carried out in rabi 2021-2022 at crop research farm, SHUATS, Prayagraj with rhizobium, vermiwash, neem and tulsi leaf extracts of varying concentrates at duration of 12hrs. in three replications with randomized block design with an objective to assess the effect of these priming treatments on chickpea and to find the promising pre-sowing treatment. The results depicted that priming is an alternate strategy to improve the growth, yield and it recorded significant variation for all the parameters that were studied on comparison to the untreated control (T0). Seed priming with T5-Vermiwash at 10% for 12 hrs. recorded field emergence of 90% and 35.00 pods per plant, 1.66 seeds per pod, 14.70 g seed yield per plant, 24.79 g of 100 seed weight, 37.65 g of biological yield per plant and 39.08 % of harvest index. Thus, priming with T5-Vermiwash at 10% for 12 hrs. was found so productive on chickpea and can be suggested for cultivation on commercial scale.
The Nexus between Economic Complexity and Foreign Direct Investment in Sub-Saharan Africa
Authors: Nguéda Romaine Doline Ngo , Kelly Arsene Mouongue
Published: June 2022

This study seeks to explore the relationship between economic complexity and foreign direct investment in Sub-Saharan African countries from 1998 to 2019. Using the ordinary least square technique, the study reveal that economic complexity in a global sense is affected positively and significantly by Foreign Direct Investment (FDI) in this region. This result was reinforced through the use of fixed effects hypothesis estimations as well as quantile regression. The findings also suggest that Gross Domestic product (GDP), trade, urbanization and education contributes to the economic sophistication of economies in Sub-Saharan Africa. Hence, policies such as investment promotion, provision of credit facilities by financial institutions, product diversification, specialization, innovation and the practice of good governance should be implemented so as to boost FDI which will go a long way contributing to the economic complexity of these economies.
Capability Factor Identification and Influence Assesment on Supply Chain Resilience in Indonesian Automotive Industry
Authors: Munikhah I Anna Tul , Ramdhani Ade Yanyan
Published: June 2022

The Automotive Industry is one of the business lines affected by the COVID-19 pandemic in Indonesia. The pandemic causes instability in the Indonesian economy from demand and sales. The supply chain is a long process consisting of parties involved directly or indirectly in fulfilling customer needs: suppliers, manufacturers, shipping, warehouses, checking, and the customers themselves. In an increasingly dynamic and volatile global environment, various events threaten to disrupt supply chain operational activities. For example, the COVID-19 pandemic has caused supply chain management to be very vulnerable due to closing access and lockdown policy. Therefore, the designed supply chain system must withstand disruptions and recover quickly at a minimal cost. Supply Chain Resilience (SCR) is the ability of the supply chain to survive, adapt, and overcome operational disruptions that can damage the supply chain system so that the supply chain can quickly recover from disruptions and reconstruct the supply chain to be stronger than before. SCR has attributes that enable companies to anticipate and overcome disruptions. The Automotive Industry in Indonesia needs to identify what capabilities have been or will be used to anticipate supply chain disruptions which are then quantified to find out which capabilities have the most effect on increasing supply chain resilience. The method used in this study is DEMATEL (Decision Making Trial And Evaluation Laboratory) - ANP (Analytic Network Process) based, which can visualize causal relationships between factors through a cause-and-effect diagram and show the extent to which these factors influence each other.
Transfer Printing of Solution‐Processed 3D ZnO Nanostructures with Ultra‐High Yield for Flexible Metasurface Color Filter
Authors: Liu Hongjun , Peng Huiren , Li Ke , Lu Liping , Deng Junhong , Liu Yanjun , Qiu Chengfeng , Li Guixin , Cheng Xing
Published: June 2022

This work describes a facile thermal transfer printing process for solution‐processed high‐quality ZnO nanostructures. Nanostructures are synthesized through patterned solution growth and transfer‐printed onto a polymer substrate with an inverted configuration. Thus, the shape of the solution‐processed ZnO nanostructures can be regulated to have diversified forms, clearly defined edges, and improved surface profiles. To further demonstrate the scalability of such transfer printing process, a metasurface color filter with 300 µm × 500 µm “windmill” pattern is designed and more than 300 000 nanorod units included. After the structures are transferred, the color filter can be gradually tuned by O2 plasma treatment. Moreover, the uneven height of as‐synthesized nanorods with different diameters can be evenly rescaled, implying a precise control over the vertical dimension. Lastly, an ultra‐high transfer accuracy is validated with a lateral displacement of less than 7 nm. The presented work demonstrates a facile and low‐cost transfer printing route toward ZnO‐based metasurfaces on flexible substrates.
Breaking the Limitation of Elevated Coulomb Interaction in Crystalline Carbon Nitride for Visible and Near‐Infrared Light Photoactivity
Authors: Zhang Guoqiang , Xu Yangsen , Rauf Muhammad , Zhu Jinyu , Li Yongliang , He Chuanxin , Ren Xiangzhong , Zhang Peixin , Mi Hongwei
Published: June 2022

Most near‐infrared (NIR) light‐responsive photocatalysts inevitably suffer from low charge separation due to the elevated Coulomb interaction between electrons and holes. Here, an n‐type doping strategy of alkaline earth metal ions is proposed in crystalline K+ implanted polymeric carbon nitride (KCN) for visible and NIR photoactivity. The n‐type doping significantly increases the electron densities and activates the n→π* electron transitions, producing NIR light absorption. In addition, the more localized valence band (VB) and the regulation of carrier effective mass and band decomposed charge density, as well as the improved conductivity by 1–2 orders of magnitude facilitate the charge transfer and separation. The proposed n‐type doping strategy improves the carrier mobility and conductivity, activates the n→π* electron transitions for NIR light absorption, and breaks the limitation of poor charge separation caused by the elevated Coulomb interaction.
Context‐dependent concordance between physiological divergence and phenotypic selection in sister taxa with contrasting phenology and mating systems
Authors: Mazer Susan J. , Hunter David J. , Hove Alisa A. , Dudley Leah S.
Published: June 2022

Premise

The study of phenotypic divergence of, and selection on, functional traits in closely related taxa provides the opportunity to detect the role of natural selection in driving diversification. If the strength or direction of selection in field populations differs between taxa in a pattern that is consistent with the phenotypic difference between them, then natural selection reinforces the divergence. Few studies have sought evidence for such concordance for physiological traits.

Methods

Herbarium specimen records were used to detect phenological differences between sister taxa independent of the effects on flowering time of long‐term variation in the climate across collection sites. In the field, physiological divergence in photosynthetic rate, transpiration rate, and instantaneous water‐use efficiency were recorded during vegetative growth and flowering in 13 field populations of two taxon pairs of Clarkia, each comprising a self‐pollinating and a outcrossing taxon.

Results

Historically, each selfing taxon flowered earlier than its outcrossing sister taxon, independent of the effects of local long‐term climatic conditions. Sister taxa differed in all focal traits, but the degree and (in one case) the direction of divergence depended on life stage. In general, self‐pollinating taxa had higher gas exchange rates, consistent with their earlier maturation. In 6 of 18 comparisons, patterns of selection were concordant with the phenotypic divergence (or lack thereof) between sister taxa.

Conclusions

Patterns of selection on physiological traits measured in heterogeneous conditions do not reliably reflect divergence between sister taxa, underscoring the need for replicated studies of the direction of selection within and among taxa.
Switchable Metasurface with Electromagnetically Induced Transparency and Absorption Simultaneously Realizing Circular Polarization‐Insensitive Circular‐to‐Linear Polarization Conversion
Authors: Gao ChengJing , Zhang HaiFeng
Published: June 2022

A metasurface (MS) with switching features from electromagnetically induced transparency (EIT) to electromagnetically induced absorption (EIA) is theoretically investigated in the terahertz (THz) range by incorporating vanadium dioxide (VO2) when circular polarization‐insensitive circularly polarized waves are incidents, which can also simultaneously realize circular‐to‐linear polarization conversion well. While the VO2 ring is in an insulator state, two new transparent EIT windows both are gained between 0.97 THz and 1.16 THz because of destructive interference between the two metal rings that are seen as bright modes. Once the VO2 ring is tuned to the metallic state, a perfect EIA phenomenon is observed between 0.824 THz and 1.233 THz, achieving the transition from the EIT to EIA behavior well. The received electromagnetic waves are radiated to left‐handed circularly polarized (LCP) or right‐handed circularly polarized (RCP) waves with identical phases and amplitudes through the radiation patches when the LCP or RCP ones are incident. Whereby, a resultant linearly polarized wave is obtained between 0.9 THz and 1.2 THz, and relative bandwidth reaches 29%. The outcomes of maximal group index and group delay both are 1934 and 488 ps at 1.08 THz, and maximal absorption is 90.3% at 1.06 THz.
Molecularly Precise, Bright, Photostable, and Biocompatible Cyanine Nanodots as Alternatives to Quantum Dots for Biomedical Applications
Authors: Yang Jiajia , Wang Kaiqi , Zheng Yihuan , Piao Ying , Wang Jinqiang , Tang Jianbin , Shen Youqing , Zhou Zhuxian
Published: June 2022

Fluorescent imaging with fluorophores has become a powerful way to explore complex biological systems and visualize nanoparticles for drug delivery. However, it is challenging to develop fluorophores with ideal physical and optical properties. We report a method to synthesize cyanine nanodots with a single‐molecule structure, well‐defined particle size, customizable fluorescent spectrum, and bright and stable fluorescence. These cyanine nanodots are acquired by the divergent synthesis of cyanine‐dye‐cored polylysine (PLL) dendrimers. We demonstrated the feasibility of the method by synthesizing cyanine 3 (Cy3), cyanine 5 (Cy5), or cyanine 7 (Cy7) cored single‐molecule nanodots up to eight generations with a size of around 11 nm. We show that these cyanine nanodots are capable of multiple biomedical applications, including multicolor cellular tracing and cancer imaging. These cyanine nanodots possess many merits of organic dots and quantum dots that are promising for future application.
Enzymatic Enantioselective anti‐Markovnikov Hydration of Aryl Alkenes
Authors: Lin Hui , Meng Yinyin , Li Na , Tang Yanhong , Dong Shuang , Wu Zhongliu , Xu Cuilian , Kazlauskas Romas , Chen Hongge
Published: June 2022

The addition of water to alkenes is an important method for the synthesis of alcohols, but the regioselectivity of acid‐catalyzed hydration of terminal alkenes yields secondary alcohols according to Markovnikov's rule, making it difficult to obtain primary alcohols. Here we report a styrene monooxygenase that catalyzes the anti‐Markovnikov hydration of the terminal aryl alkenes under anaerobic conditions. This hydration provides primary alcohols in good yields (up to 100 %), excellent anti‐Markovnikov regioselectivity (>99 : 1), and good enantiomeric purity (60–83 % ee). Residues Asn46, Asp100, and Asn309 are essential for catalysis suggesting an acid–base mechanism with a carbanion‐like intermediate that could account for the anti‐Markovnikov regioselectivity. Our work reveals a new enzymatic tool with unusual regioselectivity based on the promiscuous catalytic activity of a monooxygenase.
Solar‐Driven Overproduction of Biofuels in Microorganisms
Authors: Wang Jie , Chen Na , Bian Guangkai , Mu Xin , Du Na , Wang Wenjie , Ma Chong‐Geng , Fu Shai , Huang Bolong , Liu Tiangang , Yang Yanbing , Yuan Quan
Published: June 2022

Microbial cell factories reinvigorate current industries by producing complex fine chemicals at low costs. Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is the main reducing power to drive the biosynthetic pathways in microorganisms. However, insufficient intrinsic NADPH limits the productivity of microorganisms. Here, we report that supplying microorganisms with long‐lived electrons from persistent phosphor mesoporous Al2O3 (meso‐Al2O3) can elevate the NADPH level to facilitate efficient fine chemical production. The defects in meso‐Al2O3 were demonstrated to be highly efficient in prolonging electrons’ lifetime. The long‐lived electrons in meso‐Al2O3 can pass the material–microorganism interface and power the biosynthetic pathways of E. coli to produce jet fuel farnesene. This work represents a reliable strategy to design photo‐biosynthesis systems to improve the productivity of microorganisms with solar energy.
The wetting process and crystallisation of Al2O3 substrate with molten slags: Addition of CaO‐Fe2O3
Authors: Baoliang Xia , Hanxu Li , Facun Jiao , Lirui Mao , Chengli Wu
Published: June 2022

As fluxes, CaO and Fe2O3 are widely applied to effectively improve the melting characteristics of coal ash. However, there are few studies on the effects of CaO and Fe2O3 contents in coal ash on the wetting of refractories used in entrained‐flow slagging gasifiers. This paper investigates the melting properties of ash slag and the wetting process in corundum‐based refractories in relation to the total amount of CaO and Fe2O3 and their proportions in coal ash. The rates of change of the apparent contact angle (ACA) and differential contact angle (DCA) as a function of temperature are employed to evaluate the wetting behaviour of the coal ash during the heating process. The results demonstrate that changes in the ACA result from the expansion or shrinkage of the slag. In particular, two abrupt changes in the ACA are observed at an Fe2O3/CaO ratio of .25. The wettability deteriorates after quenching at ratios ranging from .13 to .67. Differences in the crystal structure and elemental distribution along with the spreading direction are observed. X‐ray diffraction and FactSage calculations show that temperature changes the crystal composition and solid–liquid phase content, supporting the slag wetting process from the perspective of ash fusibility. A fraction of the liquid phase increases twice with increases in temperature, explaining the abrupt change in the ACAs. Overall, the wetting process of the slag can be explained by the surface tension and DCA. The wetting begins at 430 mN m−1 and becomes the most prominent at 435 mN m−1. Finally, an Fe2O3/CaO ratio of .25 is found to be more suitable for the long‐term operation of corundum‐based refractories.
Another potential disaster? On a proposal to introduce Nile perch, Lates niloticus, into Lake Kariba (Zambia/Zimbabwe)
Authors: Marshall Brian E.
Published: June 2022

The introduction of Nile perch, Lates niloticus, into Lake Victoria resulted in a massive increase in fish catches, but with significant ecological costs. These included the near extirpation of the 500+ endemic haplochromine species and the eutrophication of the lake.

A proposal to introduce Nile perch into the artificial Lake Kariba (Zambia/Zimbabwe) is of concern, therefore, because of potentially adverse impacts on its fisheries and biodiversity.

It is very unlikely that Nile perch would improve the fisheries in Lake Kariba, as it did in lakes Victoria and Kyoga, because this lake is oligotrophic and much less productive. The principal fishery in Lake Kariba is already in difficulty, owing to overfishing, and Nile perch could reduce catches further. The biomass of other native fish species is very low and would be unlikely to support a significant Nile perch population.

Lake Kariba has already experienced a major loss of biodiversity as river‐adapted fish species have not been able to adapt to lacustrine conditions. The non‐native Nile tilapia, Oreochromis niloticus, has also replaced the endemic tilapia species in the middle Zambezi system and the Nile perch could bring about a further loss of biodiversity. The ecological costs of its introduction into Lake Kariba would not be justified by an increase in fishery productivity, and the possible introduction of Nile perch should be forcefully rejected.
Raumklimauntersuchung im „schweren” Goldenen Saal in Nürnberg und in der „leichten” Glaseinhausung der Busmannkapelle in Dresden
Authors: Häupl Peter
Published: June 2022

Auf der Basis einer vereinfachten Energie‐ und Feuchtebilanz für den bauklimatisch kritischen Raum eines Gebäudes ist ein Modell und Programm CLIMT für die Berechnung der Raumlufttemperatur und Raumluftfeuchte entwickelt worden. Außerdem ermöglicht das nutzerfreundliche Programm GLIG die Generierung der Außenklimadaten (Stundenwerte der Temperatur, der Luftfeuchte, der kurzwelligen Direkt‐ und Diffusstrahlung usw.). Die Rechenergebnisse sind mit Messwerten in zwei aktuellen Gebäuden in Deutschland verglichen worden: der Goldene Saal unter der Zeppelintribüne, der vom Hochbauamt Nürnberg seit 2015 renoviert wird und die Glaseinhausung der Busmannkapellenreplik in Dresden. Die Übereinstimmung zwischen den stündlichen Rechenwerten für die Raumlufttemperaturen und Raumluftfeuchten in den Jahren 2015 bzw. 2018 und den Messwerten in beiden Gebäuden ist beinahe perfekt. Das ist von großer Bedeutung für die Planung aller Sanierungsmaßnahmen und die museale Nutzung beider Gebäude.
LOCAL+ – ein kreislauffähiger Holzmodulbau mit nachhaltigem Energie‐ und Wohnraumkonzept
Authors: Ghinaiya Jagdishkumar , Lehmann Thomas , Göttsche Joachim
Published: June 2022

Mit dem Beitrag des Teams der FH Aachen zum SDE 21/22 wird im Projekt LOCAL+ ein kreislauffähiger Holzmodulbau mit einem innovativen Wohnraumkonzept geplant und umgesetzt. Ziel dieses Konzeptes ist die Verringerung des stetig steigenden Wohnflächenbedarfs durch ein Raum‐in‐Raum Konzept. Gebäudetechnisch wird in dem Projekt nicht nur das Einzelgebäude betrachtet, sondern unter Berücksichtigung des Gebäudebestandes wird für das Quartier ein innovatives und nachhaltiges Energiekonzept entwickelt. Ein zentrales Wasserstoffsystem ist für ein Quartier geplant, um den Stromverbrauch aus dem Netz im Winter zu reduzieren. Zentraler Bestandteil des TGA‐Konzepts ist ein unterirdischer Eisspeicher, eine PVT und eine Wärmepumpe mit intelligenter Regelstrategie. Ein Teil des neuen Gebäudes (Design Challenge DC) wird in Wuppertal als Hausdemonstrationseinheit (HDU) präsentiert. Eine hygrothermische Simulation der HDU wurde mit der WUFI‐Software durchgeführt. Da im Innenraum Lehmmodule und ‐platten als Feuchtigkeitspuffer verwendet werden, spielen die Themen Feuchtigkeit, Holzfäule und Schimmelwachstum eine wichtige Rolle.
MIMO – MINIMAL IMPACT, MAXIMUM OUTPUT – Gestapelte Tiny Houses als urbane WG
Authors: Musall Eike , Hering Janine , Brockerhoff Maximilian , Bauer Jana , Rödder Maximilian
Published: June 2022

Das interdisziplinäre Team MIMO (Minimal Impact – Maximum Output) der Hochschule Düsseldorf beschäftigt sich mit der ganzheitlich ressourceneffizienten Nachverdichtung urbaner Quartiere. Ein gründerzeitliches Industriegebäude und heutiges Tanzhaus wird energetisch saniert und um eine Wohnnutzung aufgestockt. In theoretischem Entwurf und folgender 1:1‐Umsetzung wird die Weiternutzung und Revitalisierung des Gebäudebestands, kreislaufgerechte Konstruktionen und Materialverwendung, der Einsatz recycelter, ökologischer und wiederverwertbarer Materialien, sozialnachhaltige Aspekte im Sinne von Gemeinschaft und Teilhabe sowie die Nutzung lokaler, erneuerbarer Energien zum Ausgleich der Gebäudeenergie‐ und Ökobilanz adressiert.
levelup – Modulare Aufstockung und Sanierung von Wohnblocks
Authors: Spindler Uli , Obermaier Sebastian
Published: June 2022

Das Team levelup der TH Rosenheim hat sich im Rahmen des SDE 21/22 das Ziel gesetzt, mittels Aufstockung den urbanen Raum nachzuverdichten. Hauptaugenmerk ist hierbei die Schaffung neuen Wohnraums mit einer energetischen Sanierung zum Plusenergiegebäude zu kombinieren. Erreicht wird dies durch ein Energiekonzept mit PV‐ und PVT‐Kollektoren, Absorptionswärmepumpe und einer Fassadenheizung. Der bauphysikalische Schwerpunkt in diesem Bericht liegt bei einer Sanierungsfassade mit thermischer Aktivierung der Bestandswand.
Interfacial structure design for triboelectric nanogenerators
Authors: Sun Bianjing , Xu Dan , Wang Zengbin , Zhan Yifei , Zhang Kai
Published: June 2022

Since the emergence of triboelectric nanogenerators (TENGs), new strategies, materials, and applications have been rapidly developed in the past few years to realize the efficient utilization of mechanical energy from the environment. In the pursuit of high performance, long‐term stability, and adaption in a comprehensive situation, it is necessary to fully understand the triboelectric effect and its related parameters by analyzing real‐time working status of TENG devices. This review focuses on the interface structures in TENG devices and the real‐time charge transfer process enhanced by the microstructures/nanostructures on dielectric layer surfaces, which are believed to be primely important in addition to the inherent properties of materials. Four modes of TENG operations, two main types interfaces as solid–solid interface and solid–liquid interface, as well as various materials used for device fabrication are discussed initially. Based on the real‐time working status, the interface structures of TENG devices are classified into three different groups as one‐dimensional, two‐dimensional, and three‐dimensional ones. In addition, the noncontact mode TENG devices are also described and are regarded as candidates for mechanical wear. Finally, existing challenges and the prospect of TENG devices based on the structural design of interfaces are summarized.
Comprehensive analysis of metabolic pathway activity subtypes derived prognostic signature in hepatocellular carcinoma
Authors: Huo Junyu , Cai Jinzhen , Wu Liqun
Published: June 2022

Objective

Metabolic reprogramming is one of the hallmarks of cancer, but metabolic pathway activity‐related subtypes of hepatocellular carcinoma (HCC) have not been identified.

Methods

Based on the quantification results of 41 metabolic pathway activities by gene set variation analysis, the training cohort (n = 609, merged by TCGA and GSE14520) was clustered into three subtypes (C1, C2, and C3) with the nonnegative matrix factorization method. Totally 1371 differentially expressed genes among C1, C2, and C3 were identified, and an 8‐gene risk score was established by univariable Cox regression analysis, least absolute shrinkage and selection operator method, and multivariable Cox regression analysis.

Results

C1 had the strongest metabolic activity, good prognosis, the highest CTNNB1 mutation rate, with massive infiltration of eosinophils and natural killer cells. C2 had the weakest metabolic activity, poor prognosis, was younger, was inclined to vascular invasion and advanced stage, had the highest TP53 mutation rate, exhibited a higher expression level of immune checkpoints, accompanied by massive infiltration of regulatory T cells. C3 had moderate metabolic activity and prognosis, the highest LRP1B mutation rate, and a higher infiltration level of neutrophils and macrophages. Internal cohorts (TCGA, n = 370; GSE14520, n = 239), external cohorts (ICGC, n = 231; GSE116174, n = 64), and clinical subgroup validation showed that the risk score was applicable for patients with diverse clinical features and was effective in predicting the prognosis and malignant progression of patients with HCC. Compared with the low‐risk group, the high‐risk group had a poor prognosis, enhanced cancer stem cell characteristics, activated DNA damage repair, weakened metabolic activity, cytolytic activity, and interferon response.

Conclusion

We identified HCC subtypes from the perspective of metabolism‐related pathway activity and proposed a robust prognostic signature for HCC.
Comparison of nivolumab and sorafenib for first systemic therapy in patients with hepatocellular carcinoma and Child‐Pugh B cirrhosis
Authors: Chapin William J. , Hwang Wei‐Ting , Karasic Thomas B. , McCarthy Anne Marie , Kaplan David E.
Published: June 2022

Background

Patients with decompensated cirrhosis are excluded or underrepresented in clinical trials of systemic therapies for hepatocellular carcinoma (HCC) and comparisons of available therapies are lacking. We aimed to compare overall survival for patients with HCC and Child‐Pugh B cirrhosis treated with nivolumab or sorafenib as first systemic treatment.

Methods

We performed a retrospective cohort study in patients with HCC and Child‐Pugh B cirrhosis treated at Veterans Affairs medical centers to compare overall survival, adverse events, and reason for discontinuation of therapy between patients treated with nivolumab or sorafenib as first systemic treatment. All statistical tests were 2‐sided.

Results

Of those meeting inclusion criteria, 431 patients were treated with sorafenib and 79 with nivolumab. Median OS was 4.0 months (95% CI 3.5–4.8) in the sorafenib cohort and 5.0 months (95% CI 3.3–6.8) in the nivolumab cohort. In the multivariable Cox proportional hazards model, nivolumab was associated with a significantly reduced hazard of death compared to sorafenib (HR 0.69; 95% CI 0.52–0.91; p = 0.008). In a secondary analysis using propensity score methods, results did not reach statistical significance (HR 0.77; 95% CI 0.55–1.06; p = 0.11). Treatment was discontinued due to toxicity in 12% of patients receiving nivolumab compared to 36% receiving sorafenib (p = 0.001).

Conclusion

In patients with HCC and Child‐Pugh B cirrhosis, nivolumab treatment may be associated with improved overall survival and improved tolerability compared to sorafenib and should be considered for the first systemic treatment in this population.
Phosphodiesterase‐5 Inhibitory Activity of Canthin‐6‐One Alkaloids and the Roots ofEurycoma longifoliaandEurycoma harmandiana
Authors: Choonong Rattanathorn , Chaingam Jiranan , Chantakul Ruttanaporn , Mukda Sirikan , Temkitthawon Prapapan , Ingkaninan Kornkanok , Juengwatanatrakul Thaweesak , Yusakul Gorawit , Kanchanapoom Tripetch , Putalun Waraporn
Published: June 2022

Eurycoma longifolia(EL) andEurycoma harmandiana(EH) are natural medicinal plants belonging to the Simaroubaceae family, and are well‐known for their ability to enhance male sexual performance. The present study investigated the phosphodiesterase‐5 (PDE‐5) inhibitory activity of intact roots of EL and EH. Additionally, canthin‐6‐one alkaloids,β‐carboline alkaloids, and quassinoids were also screened for PDE‐5 inhibitory activity. We developedin vitroroot and callus cultures of EL and EH to determine their PDE‐5 inhibitory activity. Our results indicated that canthin‐6‐one alkaloids, which include canthin‐6‐one‐9‐O‐β‐D‐glucopyranoside, 9‐methoxycanthin‐6‐one, canthin‐6‐one, and 9‐hydroxycanthin‐6‐one, exhibited PDE‐5 enzymatic inhibitory activity, with IC50values of 2.86±0.23, 3.30±1.03, 4.31±0.52, and 4.66±1.13 μM, respectively. The ethanolic extract of the intact roots of EL and EH, and thein vitroroot culture of EH had large amounts of canthin‐6‐one alkaloids (1.50±0.04, 2.12±0.03, and 3.48±0.08 mg/g dry weight, respectively), and showed potent PDE‐5 inhibition. Our findings indicate thatin vitroroot cultures of EH may be used to replace intact plants, and canthin‐6‐one‐9‐O‐β‐D‐glucopyranoside should be further investigated for development as a health supplement.
Exploration of Isoxazole‐Carboxylic Acid Methyl Ester Based 2‐Substituted Quinoline Derivatives as Promising Antitubercular Agents
Authors: Kumar Sahoo Santosh , Naiyaz Ahmad Mohammad , Kaul Grace , Nanduri Srinivas , Dasgupta Arunava , Chopra Sidharth , Madhavi Yaddanapudi Venkata
Published: June 2022

In pursuit of potent anti‐TB agents active against drug resistant tuberculosis (DR‐TB), herein we report synthesis and bio‐evaluation of a new series of isoxazole‐carboxylic acid methyl ester based 2‐substituted quinoline derivatives. Preliminary evaluation indicated selectivity towards Mtb H37Rv, with no inhibition of non‐tubercular mycobacterial (NTM) & bacterial pathogen panel. Out of 36 synthesized compounds, majority exhibited substantial inhibition of Mtb H37Rv (MIC 0.5–8 μg/mL). Cell viability test against Vero cells revealed no significant cytotoxicity. Further, screening against drug resistant strains (DR‐Mtb) found hit compound displaying promising potency (MIC 1–4 μg/mL). Structure optimization of the hit led to the identification of lead compound demonstrating potent inhibition of both drug‐susceptible Mtb (MIC 0.12 μg/mL) and drug‐resistant Mtb (MIC 0.25–0.5 μg/mL) along with a high selectivity index (SI) >80. Taken together, with appreciable selectivity and potent activity, these chemotypes show prospect to be turned into a potential anti‐TB candidate.
Antimelanoma Potential ofCladonia mitisAcetone Extracts – Comparativein VitroStudies in Relation to Usnic Acid Content
Authors: Grudzińska Marta , Paśko Paweł , Wróbel‐Biedrawa Dagmara , Podolak Irma , Galanty Agnieszka
Published: June 2022

In this study, the cytotoxic activity of acetone extracts ofCladonia mitiswas assessed with respect to the content of usnic acid, a secondary metabolite commonly present in this species. Following quantitative HPLC analysis of the extracts, usnic acid was isolated by preparative chromatography. The study of cytotoxic activity was performed using the MTT test on three melanoma cell lines – HTB140, A375 and WM793. The selectivity of action was also assessed by comparing the effect towards normal human keratinocytes HaCaT. The results showed a dose‐dependent cytotoxic activity of the extracts tested and usnic acid itself, but no relationship was found between the content of usnic acid and the activity of the extracts. Furthermore, the extracts showed varied, but rather low anti‐tyrosinase activity. Otherin vitroandin vivostudies are necessary to demonstrate thatC. mitisextracts may be useful in the adjuvant external treatment of skin melanoma.
Luminescent Assay for the Screening of SARS‐CoV‐2 MPro Inhibitors
Authors: Sondag Daan , Merx Jona , Rossing Emiel , Boltje Thomas J. , Löwik Dennis W. P. M. , Nelissen Frank H. T. , van Geffen Mark , van 't Veer Cornelis , van Heerde Waander L. , Rutjes Floris P. J. T.
Published: June 2022

Since the outbreak of SARS‐CoV‐2 in December 2019 millions of infections have been reported globally. The viral chymotrypsin‐like main protease (MPro) exhibits a crucial role in viral replication and represents a relevant target for antiviral drug development. In order to screen potential MPro inhibitors we developed a luminescent assay using a peptide based probe containing a cleavage site specific for MPro. This assay was validated showing IC50 values similar to those reported in the literature for known MPro inhibitors and can be used to screen new inhibitors.
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Federal mental health programs could be revamped
Authors: Knopf Alison
Published: June 2022

The Substance Abuse and Mental Health Services Administration (SAMHSA) is up for some significant changes, including a long‐awaited reauthorization — in a bill under consideration in Congress. On May 6, Frank Pallone, Jr. (D–NJ) and Cathy McMorris Rodgers (R–Wash.), chairman and ranking member of the House Energy and Commerce Committee, released proposed legislation that would reauthorize SAMHSA and revamp many of its programs. Markups (voting by the Health Subcommittee) of the bill, the Restoring Hope for Mental Health and Well‐Being Act of 2022, were scheduled for May. Changes included in the bill include changes to the Health Resources and Services Administration (HRSA).
Ternary CuCrCeOx Solid Solution Enhances N2‐Selectivity in the NO Reduction with CO in the Presence of Water and Oxygen
Authors: Wang Yuhang , Zhang Yifei , Jiang Qike , Guo Song , Baiker Alfons , Li Gao
Published: June 2022

Co‐doping of ceria with Cu and Cr forming a ternary CuCrCeOx solid solution enhances N2‐selectivity as well as NO and CO conversions compared to the corresponding singly doped ceria, CuCeOx and CrCeOx, and pristine ceria, in the absence as well as presence of water and oxygen. The comparative study of these solid‐solution catalysts indicates that the doping of ceria results in the coupling of different transition metal redox cycles, which has a strong effect on the surface population of oxygen vacancies. The temperature required to reach 95 % N2‐selectivity is shown to be nearly linearly correlated to the concentration of oxygen vacancy defects. The oxygen defect population is highest for the ternary CuCrCeOx solid solution, which exhibits the best catalytic performance, reaching 100 % N2‐selectivity at around 100 °C. Three redox cycles (CrVI/CrIII, CuII/CuI, and CeIV/CeIII) have been identified in this catalyst leading to a synergistic effect. The ternary CuCrCeOx catalyst exhibits good water tolerance and long‐term stability while the SO2 tolerance is limited due to selective blocking of the active surface oxygen defects forming SO32− species, resulting in catalyst deactivation.
Engineering PdIr Nanostructures Synergistically Induced by Self‐assembled Surfactants and Halide Ions for Alcohol Electrooxidation
Authors: Guo Ke , Fan Dongping , Teng Yixian , Xu Dongdong , Li Yafei , Bao Jianchun
Published: June 2022

The design and synthesis of metallic nanocatalysts with distinct nanostructures and composition is still a noteworthy topic in the electrochemistry field. In this work, we have realized the morphological evolution of PdIr nanostructures in aqueous solution through the synergistic effect of self‐assembled functional surfactants and different halide ions, and achieved precise control of the kinetic and thermodynamic crystalline growth due to the different reduction potential between PdCl42−, PdBr42−, and PdI42−. The actual precursors of PdCl42− resulted in ultrathin nanodendrites, PdClxBr(4−x)2− for nanosheets and fewer branched nanodendrites, PdClxI(4−x)2− for nanorings, nanoflowers and multiply concave nanocubes. Owing to the synergistic advantages of structure and composition (alloyed Ir), PdIr nanodendrites exhibited enhanced electrocatalytic activity, anti‐poisoning ability, and stability toward alcohols (including ethanol, methanol, and glycerol) electrooxidation reactions. The results would be helpful for thoroughly understanding how structure‐directing surfactants and halide ions synergistically determine the production of advanced metallic nanocrystals.
Aza‐Ortho‐Quinone Methides as Reactive Intermediates: Generation and Utility in Contemporary Asymmetric Synthesis
Authors: Liao Hsuan‐Hung , Miñoza Shinje , Lee Shao‐Chi , Rueping Magnus
Published: June 2022

The aza‐ortho‐quinone methide (aza‐o‐QM) chemistry has overwhelmingly progressed in the past few decades. This review aims to integrate various transition metal‐catalyzed and organocatalytic strategies in taming aza‐o‐QM intermediates, including the aza‐ortho‐vinylidene quinone methide (aza‐o‐VQM), aza‐ortho‐alkynyl quinone methide (aza‐o‐AQM), aza‐para‐quinone methide (aza‐p‐QM), and indole‐based aza‐o‐QM analog. These transient species are often utilized for the direct and enantioselective synthesis of complex (hetero)polycyclic or fused‐ring molecular scaffolds such as tetrahydroquinoline and indoline, among others, which are abundant in many natural products, bioactive compounds, and pharmaceuticals.
Synthesis of Carbene‐Metal‐Amido (CMA) Complexes and Their Use as Precatalysts for the Activator‐Free, Gold‐Catalyzed Addition of Carboxylic Acids to Alkynes
Authors: Ibni Hashim Ishfaq , Tzouras Nikolaos V. , Janssens Wim , Scattolin Thomas , Bourda Laurens , Bhandary Subhrajyoti , Van Hecke Kristof , Nolan Steven P. , Cazin Catherine S. J.
Published: June 2022

A straightforward synthetic protocol leading to carbene–metal–amido (CMA) complexes (metal=Au, Cu) using a mild base and an environmentally desirable solvent (EtOH) has been explored, with a focus on complexes bearing backbone‐substitutedN‐heterocyclic carbene (NHC) ligands, including BIAN‐NHCs (BIAN=bis(imino)acenaphthene). The novel CMAs were structurally characterized, and gold‐based CMAs bearing diverse NHCs were screened as simple, Brønsted‐basic precatalysts. The readily accessible complexes display high catalytic activity in the intermolecular and intramolecular hydrocarboxylation of internal alkynes and alkynoic acids respectively, while the screening reveals the ancillary ligand effect of NHCs in these catalytic systems.
Modulation of the Naked‐Eye and Fluorescence Color of a Protonated Boron‐Doped Thiazolothiazole by Anion‐Dependent Hydrogen Bonding
Authors: Hagspiel Stephan , Fantuzzi Felipe , Arrowsmith Merle , Gärtner Annalena , Fest Maximilian , Weiser Jonas , Engels Bernd , Helten Holger , Braunschweig Holger
Published: June 2022

The reaction of a cyclic alkyl(amino)carbene (CAAC)‐stabilized thiazaborolo[5,4‐d]thiazaborole (TzbTzb) with strong Brønsted acids, such as HCl, HOTf (Tf=O2SCF3) and [H(OEt2)2][BArF4] (ArF=3,5‐(CF3)2C6H3), results in the protonation of both TzbTzb nitrogen atoms. In each case X‐ray crystallographic data show coordination of the counteranions (Cl−, OTf−, BArF4−) or solvent molecules (OEt2) to the doubly protonated fused heterocycle via hydrogen‐bonding interactions, the strength of which strongly influences the 1H NMR shift of the NH protons, enabling tuning of both the visible (yellow to red) and fluorescence (green to red) colors of these salts. DFT calculations reveal that the hydrogen bonding of the counteranion or solvent to the protonated nitrogen centers affects the intramolecular TzbTzb‐to‐CAAC charge transfer character involved in the S0→S1 transition, ultimately enabling fine‐tuning of their absorption and emission spectral features.