bluuebunny/crossref_metadata_2025 huggingface dataset:
Card-Based Protocols for Private Set Intersection and Union
Authors: Doi Anastasiia , Ono Tomoki , Abe Yoshiki , Nakai Takeshi , Shinagawa Kazumasa , Watanabe Yohei , Nuida Koji , Iwamoto Mitsugu
Published: June 2024

Card-based cryptography aims to realize secure multiparty computation with physical cards. This paper is the first to address Private Set Intersection (PSI) and Private Set Union (PSU) in card-based cryptography. PSI and PSU are well-studied secure computation protocols to compute the set intersection and the set union, respectively. We show two-party PSI and PSU protocols in each of the two operation models: one is the shuffle-based model in which parties perform all operations publicly, and the other is the private-permutation-based model that allows parties to perform some operations privately. In the shuffle-based model, we show PSI and PSU protocols can be realized with existing secure AND and OR protocols, respectively. However, these protocols have an issue of increasing the number of shuffles depending on the size of the universal set. To resolve the issue, we further propose PSI and PSU protocols with only one shuffle at the cost of increasing the number of cards. In the private-permutation-based model, we show PSI and PSU protocols can be achieved with existing secure AND and OR protocols, respectively, as in the shuffle-based protocols. These protocols have an advantage of requiring only one private permutation and one communication. We further show that the number of cards of these protocols can be reduced at the cost of increasing the number of private permutations and communications.
FPO++: efficient encoding and rendering of dynamic neural radiance fields by analyzing and enhancing Fourier PlenOctrees
Authors: Rabich Saskia , Stotko Patrick , Klein Reinhard
Published: June 2024

Fourier PlenOctrees have shown to be an efficient representation for real-time rendering of dynamic neural radiance fields (NeRF). Despite its many advantages, this method suffers from artifacts introduced by the involved compression when combining it with recent state-of-the-art techniques for training the static per-frame NeRF models. In this paper, we perform an in-depth analysis of these artifacts and leverage the resulting insights to propose an improved representation. In particular, we present a novel density encoding that adapts the Fourier-based compression to the characteristics of the transfer function used by the underlying volume rendering procedure and leads to a substantial reduction of artifacts in the dynamic model. We demonstrate the effectiveness of our enhanced Fourier PlenOctrees in the scope of quantitative and qualitative evaluations on synthetic and real-world scenes.
Recalibration of missing low-frequency variability and trends in the North Atlantic Oscillation
Authors: Eade R. , Stephenson D. B. , Scaife A. A. , Smith D. M.
Published: June 2024

Multi-decadal trends in the wintertime North Atlantic Oscillation (NAO) are under-represented by coupled general circulation models (CGCMs), consistent with a lack of autocorrelation in their NAO index series. This study proposes and tests two simple “reddening” approaches for correcting this problem in simulated indices based on simple one parameter short-term (AR; Auto-Regressive order 1) and long-term (FD; Fractional-Difference) time series filters. Using CGCMs from the Coupled Model Intercomparison Project Phase 6 (CMIP6), the FD filter successfully improves the autocorrelation structure of the NAO, and in turn the simulation of extreme trends, while the AR filter is less successful. The 1963–1993 NAO trend is the maximum 31-year trend in the historical period. Raw CGCMs underestimate the likelihood of this trend by a factor of ten but this discrepancy is corrected after reddening. CMIP6 future projections show that long-term (2024–2094) NAO ensemble mean trends systematically increase with the magnitude of radiative forcing: -2.4 to 3.5 hPa/century for low-to-high forcing after reddening (more than double the range using raw output). The related likelihood of future maximum 31year trends comparable to 1963–1993 ranges from 3 to 7% whereas none of these CMIP6 projections simulate this without reddening. Near-term projections of the next 31 years (2024–2054) are less sensitive than long term trends to the future scenario, showing weak-to-no forced trend. However, reddening increases the ensemble range by 74% (to +/-1 standard deviation/decade), which could increase/decrease regional climate change signals in the Northern Hemisphere by magnitudes that are underestimated when using raw CGCM output.
Analytical and numerical analysis on local and global buckling of sandwich panels with strut-based lattice cores
Authors: Georges Hussam , Becker Wilfried , Mittelstedt Christian
Published: June 2024

Additive manufacturing (AM) offers new possibilities to fabricate and design lightweight lattice materials. Due to the superior mechanical properties of these lattice structures, they have the potential to replace honeycombs as cores in sandwich panels. In addition to the advantage of the integral fabrication thanks to AM, additively manufactured lattice core sandwich panels may be also used as heat exchangers, enabling a multifunctional use of the core. To ensure a reliable and safe structure, the mechanical response of lattice core sandwich panels under given load conditions must be predictable. In conventional sandwich panels subjected to compressive loads, the sandwich’s global buckling and the face sheets’ local buckling are the dominant failure modes. In constrast, core strut buckling may be the critical failure mode in lattice core sandwich panels. Therefore, an analytical 2D model to predict the local buckling of lattice core struts is considered in this study. Furthermore, the critical load for global buckling is obtained based on the first-order shear deformation theory. Thus, the transition from local buckling to global buckling depending on the length-to-thickness ratio is captured by the presented model. The comparison with finite element modeling of the sandwich model with truss cores has proved the accuracy of the derived model.
DNAJC1 facilitates glioblastoma progression by promoting extracellular matrix reorganization and macrophage infiltration
Authors: Zhang Han , Zheng Wenjing , Chen Xu , Sa Longqi , Huo Yi , Zhang Lingling , Shan Lequn , Wang Tao
Published: June 2024

Background

Glioblastoma (GBM) is a high-grade and heterogeneous subtype of glioma that presents a substantial challenge to human health, characterized by a poor prognosis and low survival rates. Despite its known involvement in regulating leukemia and melanoma, the function and mechanism of DNAJC1 in GBM remain poorly understood.

Methods

Utilizing data from the TCGA, CGGA, and GEO databases, we investigated the expression pattern of DNAJC1 and its correlation with clinical characteristics in GBM specimens. Loss-of-function experiments were conducted to explore the impact of DNAJC1 on GBM cell lines, with co-culture experiments assessing macrophage infiltration and functional marker expression.

Results

Our analysis demonstrated frequent overexpression of DNAJC1 in GBM, significantly associated with various clinical characteristics including WHO grade, IDH status, chromosome 1p/19q codeletion, and histological type. Moreover, Kaplan‒Meier and ROC analyses revealed DNAJC1 as a negative prognostic predictor and a promising diagnostic biomarker for GBM patients. Functional studies indicated that silencing DNAJC1 impeded cell proliferation and migration, induced cell cycle arrest, and enhanced apoptosis. Mechanistically, DNAJC1 was implicated in stimulating extracellular matrix reorganization, triggering the epithelial-mesenchymal transition (EMT) process, and initiating immunosuppressive macrophage infiltration.

Conclusions

Our findings underscore the pivotal role of DNAJC1 in GBM pathogenesis, suggesting its potential as a diagnostic and therapeutic target for this challenging disease.
Bounds for the Regularity Radius of Delone Sets
Authors: Dolbilin Nikolay , Garber Alexey , Schulte Egon , Senechal Marjorie
Published: June 2024

Delone sets are discrete point setsXin$${\mathbb {R}}^d$$Rdcharacterized by parameters (r, R), where (usually) 2ris the smallest inter-point distance ofX, andRis the radius of a largest “empty ball” that can be inserted into the interstices ofX. The regularity radius$${\hat{\rho }}_d$$ρ^dis defined as the smallest positive number$$\rho $$ρsuch that each Delone set with congruent clusters of radius$$\rho $$ρis a regular system, that is, a point orbit under a crystallographic group. We discuss two conjectures on the growth behavior of the regularity radius. Our “Weak Conjecture” states that$${\hat{\rho }}_{d}={\textrm{O}(d^2\log _2 d)}R$$ρ^d=O(d2log2d)Ras$$d\rightarrow \infty $$d→∞, independent of r. This is verified in the paper for two important subfamilies of Delone sets: those with full-dimensional clusters of radius 2rand those with full-dimensional sets ofd-reachable points. We also offer support for the plausibility of a “Strong Conjecture”, stating that$${\hat{\rho }}_{d}={\textrm{O}(d\log _2 d)}R$$ρ^d=O(dlog2d)Ras$$d\rightarrow \infty $$d→∞, independent ofr.
Pre-Failure Strain Localization in Siliclastic Rocks: A Comparative Study of Laboratory and Numerical Approaches
Authors: Bianchi Patrick , Selvadurai Paul Antony , Dal Zilio Luca , Salazar Vásquez Antonio , Madonna Claudio , Gerya Taras , Wiemer Stefan
Published: June 2024

We combined novel laboratory techniques and numerical modeling to investigate (a)seismic preparatory processes associated with deformation localization during a triaxial failure test on a dry sample of Berea sandstone. Laboratory observations were quantified by measuring strain localization on the sample surface with a distributed strain sensing (DSS) array, utilizing optical fibers, in conjunction with both passive and active acoustic emission (AE) techniques. A physics-based computational model was subsequently employed to understand the underlying physics of these observations and to establish a spatio-temporal correlation between the laboratory and modeling results. These simulations revealed three distinct stages of preparatory processes: (i) highly dissipative fronts propagated towards the middle of the sample correlating with the observed acoustic emission locations; (ii) dissipative regions were individuated in the middle of the sample and could be linked to a discernible decrease of the P-wave velocities; (iii) a system of conjugate bands formed, coalesced into a single band that grew from the center towards the sample surface and was interpreted to be representative for the preparation of a weak plane. Dilatative lobes at the process zones of the weak plane extended outwards and grew to the surface, causing strain localization and an acceleration of the simulated deformation prior to failure. This was also observed during the experiment with the strain rate measurements and spatio-temporally correlated with an increase of the seismicity rate in a similar rock volume. The combined approach of such laboratory and numerical techniques provides an enriched view of (a)seismic preparatory processes preceding the mainshock.
Simultaneous sealing and bisection of porcine renal blood vessels, ex vivo, using a continuous-wave, infrared diode laser at 1470 nm
Authors: Saeed Woheeb M. , Yoshino Jude K. , Traynham Alexandria J. , Fried Nathaniel M.
Published: June 2024

Electrosurgical and ultrasonic devices are used in surgical procedures for hemostatic sealing and bisection of vascular tissues. Previous benchtop studies alternatively demonstrated successful infrared laser sealing and cutting of blood vessels, in a sequential, two-step approach. This study describes a smaller, laparoscopic device compatible design, and simultaneous approach to sealing and bisection of vessels, with potential optical feedback. A 1470-nm infrared diode laser sealed and bisected 40 porcine renal arteries, ex vivo. A reciprocating, side-firing, optical fiber, housed in a transparent square quartz optical chamber (2.7 × 2.7 × 25 mm outer dimensions), delivered laser energy over an 11 mm scan length, with a range of incident powers (41–59 W) and treatment times (5–21 s). Vessel diameters ranged from 2.5 to 4.8 mm. Vessel burst pressure measurements were performed on each cut end (n = 80) with success indicated by pressures exceeding 360 mmHg. All vessel ends were successfully sealed and bisected (80/80). The highest incident power, 59 W, yielded short treatment times of 5–6 s. Peak temperatures on the external chamber surface reached 103 oC. Time to cool down to body temperature measured 37 s. Infrared lasers simultaneously seal and bisect blood vessels, with treatment times comparable to, and temperatures and cooling times lower than reported for conventional devices. Future work will focus on integrating the fiber and chamber into a standard 5-mm-outer-diameter laparoscopic device. Customization of fiber scan length to match vessel size may also reduce laser energy deposition, enabling lower peak temperatures, treatment times, and cooling times.
Long non-coding RNAs in ferroptosis and cuproptosis impact on prognosis and treatment in hepatocellular carcinoma
Authors: Wang Kun , Yang Chunqian , Xie Jingen , Zhang Xiao , Wei Ting , Yan Zhu
Published: June 2024

Ferroptosis and cuproptosis are recently discovered forms of cell death that have gained interest as potential cancer treatments, particularly for hepatocellular carcinoma. Long non-coding RNAs (lncRNAs) influence cancer cell activity by interacting with various nucleic acids and proteins. However, the role of ferroptosis and cuproptosis-related lncRNAs (FCRLs) in cancer remains underexplored. Ferroptosis and cuproptosis scores for each sample were assessed using Gene Set Variation Analysis (GSVA). Weighted correlation network analysis identified the FCRLs most relevant to our study. A risk model based on FCRLs was developed to categorize patients into high-risk and low-risk groups. We then compared overall survival (OS), tumor immune microenvironment, and clinical characteristics between these groups. The IPS score and ImmuCellAI webpage were used to predict the association between FCRL-related signatures and immunotherapy response. Finally, we validated the accuracy of FCRLs in hepatocellular carcinoma cell lines using induction agents (elesclomol and erastin). Patients in different risk subgroups showed significant differences in OS, immune cell infiltration, pathway activity, and clinical characteristics. Cellular assays revealed significant changes in the expression of AC019080.5, AC145207.5, MIR210HG, and LINC01063 in HCC cell lines following the addition of ferroptosis and cuproptosis inducers. We created a signature of four FCRLs that accurately predicted survival in HCC patients, laid the foundation for basic research related to ferroptosis and cuproptosis in hepatocellular carcinoma, and provided therapeutic recommendations for HCC patients.
Functional shocks to inflation expectations and real interest rates and their macroeconomic effects
Authors: Anderl Christina , Caporale Guglielmo Maria
Published: June 2024

This paper applies a recently developed method (Inoue and Rossi, 2021) to estimate functional inflation expectations and ex-ante real interest rate shocks, and then examines their macroeconomic effects in the context of a Functional Vector Autoregressive model with exogenous variables (Functional VARX). Monthly data from January 1998 to May 2023 for the US, the UK and the euro area are used for the analysis. The estimated impulse responses show significant effects of the functional shocks on both inflation and output. In addition, threshold functional local projections indicate that the effects are nonlinear and depend on central bank credibility. Further, inflation expectations shocks have similar effects to supply (demand) ones when they are driven by long-term (short-term) changes. In the presence of an inverted (steepening) real interest rate term structure, the effects are inflationary (deflationary) and expansionary (recessionary). Finally, the responses of inflation, output and the policy rate are driven primarily by the slope and curvature factors of the term structure shocks, which contain important information not captured by traditional scalar shocks.
The beating heart: artificial intelligence for cardiovascular application in the clinic
Authors: Villegas-Martinez Manuel , de Villedon de Naide Victor , Muthurangu Vivek , Bustin Aurélien
Published: June 2024

Artificial intelligence (AI) integration in cardiac magnetic resonance imaging presents new and exciting avenues for advancing patient care, automating post-processing tasks, and enhancing diagnostic precision and outcomes. The use of AI significantly streamlines the examination workflow through the reduction of acquisition and postprocessing durations, coupled with the automation of scan planning and acquisition parameters selection. This has led to a notable improvement in examination workflow efficiency, a reduction in operator variability, and an enhancement in overall image quality. Importantly, AI unlocks new possibilities to achieve spatial resolutions that were previously unattainable in patients. Furthermore, the potential for low-dose and contrast-agent-free imaging represents a stride toward safer and more patient-friendly diagnostic procedures. Beyond these benefits, AI facilitates precise risk stratification and prognosis evaluation by adeptly analysing extensive datasets. This comprehensive review article explores recent applications of AI in the realm of cardiac magnetic resonance imaging, offering insights into its transformative potential in the field.
How can optimized forest management plan regulate noise levels from wind turbines?
Authors: Heinonen Tero , Selkimäki Mari , Rana Parvez , Tokola Timo
Published: June 2024

Wind energy has emerged as one of the most economically viable renewable energy options in the transition towards a fossil-free society. In Finland, wind farms, consisting of several wind turbines, are commonly located in forested areas, prompting concerns about their potential audio-visual impacts. Despite this, research into how forests might mitigate the adverse effects of wind farms are limited. Forests can effectively serve as noise barrier, with their noise attenuation capacity varying based on the forest’s characteristics. Specifically, the attenuation level depends on the sound’s travel distance through the forest, as well as the size and density of trees. Our study findings indicate that forests can provide up to 10 dB of additional noise attenuation. This was achieved by integrating a forest structure-based model into forest planning calculations, aimed at mitigating noise pollution from wind turbines. Incorporating this noise model as a management objective significantly reduced noise levels in the pilot study area, outperforming traditional business-as-usual management strategies. Furthermore, adapting a combination of uneven-aged and even-aged forest management approaches resulted in more forested landscape, which was more effective in mitigating higher noise levels. Our results contribute important insights that, along with further research, can guide future forest planning and management towards enhanced sustainability.
Abuse disclosure and documentation in the medical record: an observational matched-cohort study in the US Military Health System
Authors: Petrini Julia M. , Carreño Patricia K. , Subramani Dhanusha , Lutgendorf Monica A. , Velosky Alexander G. , Patzkowski Michael S. , Herrera Germaine F. , Highland Krista B.
Published: June 2024

Aim

This study aims to evaluate the overall incidence of abuse code documentation in the medical records of patients assigned female, and the relationships between abuse code documentation and patient characteristics, healthcare utilization (e.g., overall visits, emergency room visits, opioid prescription receipts), and diagnoses received in the year following documentation.

Subject and methods

Records of patients assigned female in the medical record were evaluated in this observational, retrospective study, which received a non-research determination by the Brooke Army Medical Center Institutional Review Board (C.2019.156n). Patient cohorts included those who received an initial healthcare encounter (i.e., index visit) in which physical, sexual, or psychological abuse was documented and those who never received documentation corresponding to abuse during the study period.

Results

The probability of abuse code documentation varied across patient characteristics and medical information. Using 1:1 propensity score matching, patients who received abuse code documentation had higher post-index healthcare utilization overall, as well as increased odds of an emergency visit, receipt of a mental health diagnosis, and receipt of an opioid prescription within a year of the index date.

Conclusion

These findings highlight the need for system-level interventions to ensure standardized screening and care pathways for those who experience abuse. Such programs could mitigate barriers to patient disclosure of abuse and support patient-centered policies.
Factors influencing variation in reproduction in invasive species: a case study of the Asian shore crab Hemigrapsus sanguineus
Authors: Griffen Blaine D. , Bolander Mikayla , Fletcher Laura S. , Luckett Johanna , Repetto Michele F. , Smith Nanette , Stancil Carter , Toscano Benjamin J.
Published: June 2024

Reproductive success is a strong determinant of invasive species success. It is common for studies on invasive species to assess reproduction by measuring size-specific fecundity and scaling this up using population size or densities. Yet, reproductive success is influenced by numerous factors that are not accounted for in such calculations. We examined the influence of several factors on fecundity (clutch size) and egg size in the Asian shore crab Hemigrapsus sanguineus, including body size, spatial variation throughout the invaded range, season, fertilization success, brood loss, and diet. We show that all of these factors influence reproduction simultaneously within the invaded North American range of this species, though the relative importance of these different factors varied across sites or sampling times. Our study demonstrates that numerous factors may influence the reproductive success of invasive species and that studies that rely on fecundity measured at a single place and time, or that ignore factors such as offspring quality or brood loss, may provide a skewed picture of reproduction, and thus of potential invasive success.
Myocardial performance imaging for the early identification of cardiac dysfunction in neonates with sepsis
Authors: Sumbaraju Sudheshna Lalitha , Nayak Krishnananda , Prabhu Sridevi , Nayak Vidya , Prabhu K Prathiksha , Lewis Leslie Edward
Published: June 2024

Purpose

The assessment of cardiac performance in septic new-borns is crucial for detecting hemodynamic instability and predicting outcome. The aim of the study is to assess myocardial performance in neonates with sepsis for the early identification of cardiac dysfunction.

Patients and methods

A case control study was carried out from September 2022 to May 2023 at the Neonatal Intensive care unit, Kasturba Medical College, Manipal. A total of 68 neonates were included in the study, with 33 females and 35 males. The study population was further subdivided into 3 groups namely preterm septic neonates (n = 21), term septic neonates (n = 10) and non-septic healthy controls (n = 37). The cardiac structure and function were assessed using conventional method, Tissue Doppler imaging (Sm) and speckle tracking echocardiography (GLS). The study was approved by the Institutional Ethics Committee at Kasturba Medical College, Manipal (approval number IEC: 90/2022). The CTRI registration number for the study is CTRI/2022/09/045437 and was approved on September 12, 2022. Prior to the neonate’s enrolment, informed consent was obtained from their mothers or legal guardians.

Results

Out of the total 68 neonates, 31 were cases and 37 were controls which included 33 females and 35 males. LV systolic function was not statistically significant between cases and controls. E/A ratio of the mitral valve was significantly lower in septic newborns than in healthy neonates. (1.01 ± 0.35 vs 1.18 ± 0.31, p < 0.05) preterm neonates showed significantly lower Lateral E’ and RV E’ velocities than term neonates. TAPSE was significantly lower in septic preterm neonates. (8.61 ± 1.28 vs. 10.7 ± 2.11, p < 0.05) No significant difference was noted in the Myocardial Performance Index between septic neonates and healthy neonates. LV Global Longitudinal Strain was slightly lower in preterm septic neonates than in term neonates with sepsis.

Conclusion

Septic newborns are associated with LV diastolic dysfunction, RV systolic dysfunction and substantially higher pulmonary systolic pressures.
Pharmacological Modulation of the Cytosolic Oscillator Affects Glioblastoma Cell Biology
Authors: Wagner Paula M. , Fornasier Santiago J. , Guido Mario E.
Published: June 2024

The circadian system is a conserved time-keeping machinery that regulates a wide range of processes such as sleep/wake, feeding/fasting, and activity/rest cycles to coordinate behavior and physiology. Circadian disruption can be a contributing factor in the development of metabolic diseases, inflammatory disorders, and higher risk of cancer. Glioblastoma (GBM) is a highly aggressive grade 4 brain tumor that is resistant to conventional therapies and has a poor prognosis after diagnosis, with a median survival of only 12–15 months. GBM cells kept in culture were shown to contain a functional circadian oscillator. In seeking more efficient therapies with lower side effects, we evaluated the pharmacological modulation of the circadian clock by targeting the cytosolic kinases glycogen synthase kinase-3 (GSK-3) and casein kinase 1 ε/δ (CK1ε/δ) with specific inhibitors (CHIR99021 and PF670462, respectively), the cryptochrome protein stabilizer (KL001), or circadian disruption after Per2 knockdown expression in GBM-derived cells. CHIR99021-treated cells had a significant effect on cell viability, clock protein expression, migration, and cell cycle distribution. Moreover, cultures exhibited higher levels of reactive oxygen species and alterations in lipid droplet content after GSK-3 inhibition compared to control cells. The combined treatment of CHIR99021 with temozolomide was found to improve the effect on cell viability compared to temozolomide therapy alone. Per2 disruption affected both GBM migration and cell cycle progression. Overall, our results suggest that pharmacological modulation or molecular clock disruption severely affects GBM cell biology.
A novel hybrid Artificial Gorilla Troops Optimizer with Honey Badger Algorithm for solving cloud scheduling problem
Authors: Hussien Abdelazim G. , Chhabra Amit , Hashim Fatma A. , Pop Adrian
Published: June 2024

Cloud computing has revolutionized the way a variety of ubiquitous computing resources are provided to users with ease and on a pay-per-usage basis. Task scheduling problem is an important challenge, which involves assigning resources to users’ Bag-of-Tasks applications in a way that maximizes either system provider or user performance or both. With the increase in system size and the number of applications, the Bag-of-Tasks scheduling (BoTS) problem becomes more complex due to the expansion of search space. Such a problem falls in the category of NP-hard optimization challenges, which are often effectively tackled by metaheuristics. However, standalone metaheuristics generally suffer from certain deficiencies which affect their searching efficiency resulting in deteriorated final performance. This paper aims to introduce an optimal hybrid metaheuristic algorithm by leveraging the strengths of both the Artificial Gorilla Troops Optimizer (GTO) and the Honey Badger Algorithm (HBA) to find an approximate scheduling solution for the BoTS problem. While the original GTO has demonstrated effectiveness since its inception, it possesses limitations, particularly in addressing composite and high-dimensional problems. To address these limitations, this paper proposes a novel approach by introducing a new updating equation inspired by the HBA, specifically designed to enhance the exploitation phase of the algorithm. Through this integration, the goal is to overcome the drawbacks of the GTO and improve its performance in solving complex optimization problems. The initial performance of the GTOHBA algorithm tested on standard CEC2017 and CEC2022 benchmarks shows significant performance improvement over the baseline metaheuristics. Later on, we applied the proposed GTOHBA on the BoTS problem using standard parallel workloads (CEA-Curie and HPC2N) to optimize makespan and energy objectives. The obtained outcomes of the proposed GTOHBA are compared to the scheduling techniques based on well-known metaheuristics under the same experimental conditions using standard statistical measures and box plots. In the case of CEA-Curie workloads, the GTOHBA produced makespan and energy consumption reduction in the range of 8.12–22.76% and 6.2–18.00%, respectively over the compared metaheuristics. Whereas for the HPC2N workloads, GTOHBA achieved 8.46–30.97% makespan reduction and 8.51–33.41% energy consumption reduction against the tested metaheuristics. In conclusion, the proposed hybrid metaheuristic algorithm provides a promising solution to the BoTS problem, that can enhance the performance and efficiency of cloud computing systems.
Disparities in Access to Mental Health Services Among Children Diagnosed with Anxiety and Depression in the United States
Authors: Mahmood Asos , Kedia Satish , Arshad Hassan , Mou Xichen , Dillon Patrick J.
Published: June 2024

Child and adolescent mental health are major public health concerns in the US. Overall, 20% of US children have a reported mental health condition, while an estimated 40% will be diagnosed with one by age 18. Despite these concerns, little is known about factors associated with access to mental health services among children and adolescents. We analyzed data from a sample of 6655 children (aged 6 to 17 years) with either anxiety and/or depression drawn from the 2020–2021 National Survey of Children’s Health (NSCH). A multivariable logistic regression model was fit to investigate predisposing, enabling, and need factors associated with caregiver’s (i.e., parent or other guardian) perceived access to mental health services for their children. Approximately 50.8% of caregivers perceived obtaining mental health services for their children to be somewhat difficult, very difficult, or impossible. Children meeting criteria for having a medical home had lower odds of experiencing such difficulties (adjusted [a]OR = 0.38; 95% CI: 0.30–0.49). Further, compared to children who sometimes or never had health insurance coverage for mental or behavioral health needs, children who were always insured (aOR: 0.19; 95% CI 0.14, 0.25) and those who usually had coverage (aOR: 0.38; 95% CI 0.28, 0.51) had lower odds of experiencing perceived difficulties in obtaining care. The results indicate several enabling and need predictors of perceived access to mental health services––highlighting potential structural barriers to care access. Efforts to address access challenges should adopt a multifaceted approach and be tailored to families living in poverty, those with limited health coverage, and minoritized children with less than optimal general health.
Occasional Reinforced Extinction as a Method for Relapse Prevention: A Critical Systematic Review and Future Directions
Authors: Quintero María J. , López Francisco J. , Vadillo Miguel A. , Morís Joaquín
Published: June 2024

Introduction

Extinction is more vulnerable than the original acquisition memory, as relapse phenomena have systematically shown in the literature with different species and procedures. One strategy potentially useful to mitigate relapse is occasional reinforced extinction (ORE). In contrast to a standard extinction procedure, this strategy consists of the inclusion of a gradual and sparse number of conditioned stimulus–unconditioned stimulus pairings within the extinction phase. Here, we provide a comprehensive review of the available literature on ORE.

Method

We conducted a literature search using three databases (Web of Science, Scopus, and PsycInfo) in July 2022, with an additional citation search. We collected data on different variables of interest, like the relapse phenomena being studied, the outcome measures, or the specific effects obtained.

Results

A total of 350 studies were identified from the main database search, including 10 in the review. Five additional studies from the citation search were also included. The final sample consisted of 15 empirical reports. The observed procedural variability makes it difficult to evaluate the effectiveness of ORE to reduce different forms of relapse as the strategy has not consistently shown a general advantage over standard extinction.

Conclusion

The current evidence assessing the effectiveness of ORE does not appear to be consistent, although there are plenty theoretical studies recommending and discussing the potential effectiveness of such technique. Moreover, the lack of conclusive laboratory evidence calls into question how general the potential benefits of its use in clinical settings would be.
Old-Keynesianism in the New Keynesian Model
Authors: van der Kwaak Christiaan
Published: June 2024

I investigate an ‘old Keynesian’ fiscal policy in which government spending endogenously responds to inflation and the output gap when the nominal interest rate is pegged at the ZLB. I do so within a standard Representative Agent New Keynesian model (RANK), as well as a two-period Overlapping Generations New Keynesian model (OLG-NK). For both model versions, I find that the equilibrium values for inflation and the output gap under a standard Taylor rule regime can be replicated under the ‘old Keynesian’ regime. However, a unique stable countercyclical equilibrium is only feasible within the OLG-NK model and crucially depends on the pension system.
How Learners’ Visuospatial Ability and Different Ways of Changing the Perspective Influence Learning About Movements in Desktop and Immersive Virtual Reality Environments
Authors: Brucker Birgit , Pardi Georg , Uehlin Fabienne , Moosmann Laura , Lachmair Martin , Halfmann Marc , Gerjets Peter
Published: June 2024

Virtual reality (VR) applications are developing rapidly, becoming more and more affordable, and offer various advantages for learning contexts. Dynamic visualizations are generally suitable for depicting continuous processes (e.g., different movement patterns), and particularly dynamic virtual 3D-objects can provide different perspectives on the movements. The present study investigated through a low immersive (desktop “VR”, Study 1) and a high immersive virtual environment (immersive VR; Study 2) the effectiveness of different interaction formats to view 3D-objects from different perspectives. Participants controlled either the orientation of the 3D-objects (Study 1, mouse interaction; Study 2, hand interaction via VR controllers) or their viewpoint in relation to the 3D-objects (Study 1, camera position; Study 2, position of participants’ own body). Additionally, the moderating influence of learners’ visuospatial ability was addressed. Dependent variables were pictorial recognition (easy, medium, difficult), factual knowledge, presence, and motion sickness. Results showed that higher-visuospatial-ability learners outperformed lower-visuospatial-ability learners. In Study 1, higher-visuospatial-ability learners showed higher recognition performance (difficult items) by controlling the camera position, whereas lower-visuospatial-ability learners suffered from this interaction format. In Study 2, higher-visuospatial-ability learners achieved better recognition performance (easy items) by controlling the 3D-models, whereas lower-visuospatial-ability learners tended to profit from moving around the 3D-objects (medium items). The immersive VR yielded more presence and higher motion sickness. This study clearly shows that different interaction formats to view 3D-objects from multiple perspectives in Desktop-VR are not transferable on a one-to-one basis into immersive VR. The results and implications for the design of virtual learning environments are discussed.
Development of high school students’ conceptions of sampling distribution in the context of learning significance tests with technology
Authors: Sánchez Ernesto , García-Ríos Victor Nozair , Sepúlveda Francisco
Published: June 2024

Sampling distributions are fundamental for statistical inference, yet their abstract nature poses challenges for students. This research investigates the development of high school students’ conceptions of sampling distribution through informal significance tests with the aid of digital technology. The study focuses on how technological tools contribute to forming these conceptions, guided by an emerging theory that describes this process. A workshop for high school students was organized, involving 36 participants working in pairs across four sessions, each with access to a computer. These sessions involved problem-solving activities, with the teacher introducing key concepts in the initial three sessions. The analysis, employing grounded theory, aimed to characterize the nature of students’ conceptions of sampling distribution as evident in their responses. The findings reveal a transition from empirical to informal conceptions of sampling distribution among students, facilitated by computational mediation. This transition is marked by an abstraction process that includes mathematization, processing, uncertainty/randomness, and conditional reasoning. The study underscores the role of digital simulations in teaching statistical concepts, facilitating students’ conceptual shift critical for grasping statistical inference.
Effectiveness of countermeasure options for chemical facilities against the discharge of chemical substances into rivers caused by a large earthquake: case study of the Yodo river system in Osaka prefecture, Japan
Authors: Hamamoto Shogo , Tokai Akihiro , Nakakubo Toyohiko , Ito Lisa
Published: June 2024

Technological accidents triggered by natural hazards, which are commonly referred to as Natech events, are rare occurrences yet carry the potential for significant damage. Specifically, the release of hazardous chemicals into the aquatic environment and community water systems poses a grave threat to human health and society. Accordingly, we must conduct assessments that consider the potential consequences of these accidents. In this study, we examined the criteria for implementing spill protection measures to mitigate river spills of chemical substances using information on the amount of chemical substances and their toxicity. The countermeasure options readily available to employees at industrial plants and chemical storage sites where a chemical spill might originate included emergency shut-off valves, bunds and related spill containment structures, and other spill prevention measures. In this case study, a combination of countermeasure options was evaluated to examine the effectiveness of spill mitigation in the Yodo River located in the Kyoto Prefecture of Japan. Results of the case study showed that bunds were emerged as the most useful countermeasure option, reducing the probability of accidents occurring and impact of accidents. We also defined a methodology for calculating the chemical storage volumes appropriate for different countermeasures to ensure that the concentration of chemicals that could reach the water intake does not exceed the standard values. We believe that these methodologies can help chemical-handling companies make decisions when countermeasure options for responding to a chemical spill into a river. Chemical-handling companies can estimate the risk to downstream water treatment plants in the chemical spill, which can also help them consider mitigation measures.
Genotype by environment interaction influence on functional molecules (tocopherols and sterols) accumulation in sunflower oil
Authors: Hussain Masood , Rauf Saeed , Ortiz Rodomiro , Al-Khayri Jameel M. , Tauqir Nasir A. , Elbok Safia
Published: June 2024

Tocopherol and sterol are non-dietary functional molecules in sunflower oil, which act as antioxidants, reduce cholesterol and improve immunity against diseases. The present study was designed to determine tocopherol and sterol contents in 13 high and two low oleic acid sunflower hybrids across two seasons (spring and autumn) and four locations under subtropical conditions of Pakistan with contrasting reproductive phase temperatures. The results showed that tocopherol and sterol contents varied across the seasons and locations. Autumn planting produced high tocopherol content. Moreover, locations under high temperature during reproductive phase negatively affected the sterol and tocopherol contents. High oleic acid hybrids yielded 38% higher tocopherol content than low oleic acid hybrids. High oleic acid hybrids produced higher sterol contents at all locations and seasons. Hybrids such as H4 and H5 are considered stable due to comparatively close values of tocopherol and sterol contents across the four locations when compared with standard checks and other hybrids during spring season as indicated from various stability parameters. Hybrids H8, H4 and H5 also manifested higher magnitude of heterosis for tocopherol and sterol contents that may be due to overdominance gene action. Breeding lines such as B.116.P, B.112.P and RH.365 were positive combiners for the investigated traits, thus likely carrying positive alleles for both tocopherol and sterol traits.
The Establishment of the Agricultural Landscape of Central Sicily Between the Middle Neolithic and the Beginning of the Iron Age
Authors: Speciale Claudia , Giannitrapani Enrico , Mercuri Anna Maria , Florenzano Assunta , Sadori Laura , Combourieu-Nebout Nathalie
Published: June 2024

The possible co-variation of human occupation and vegetation from the Middle Neolithic to the beginning of the Iron Age (7.5–2.8 ka BP) in Central Sicily in the context of the central Mediterranean between Middle and Late Holocene are analysed in this paper to provide new insights on Sicilian prehistoric demography. The demographic and economic trends during these millennia were reconstructed using archaeological, Accelerator Mass Spectrometry 14C dates, palynological, archaeobotanical, and zooarchaeological data from the northern, central, and southern sectors of Central Sicily through a diachronic comparison with variation in Arboreal Pollen, Anthropogenic Pollen Indicators, Olea-Juglans-Castanea pollen, microcharcoals, and Sporormiella from four pollen cores from sites in different ecosystems. A very significant spread of farming activities was found at the end of the Neolithic, together with an apparent demographic gap during the Middle Copper Age, and the emergence of agricultural landscapes at the end of the Copper Age associated with a striking increase in population. A combination of cultural and climatic changes during the late phase of the Bronze Age resulted in a subsequent overall decrease in population.
Gaining Knowledge of a New and Contested Diagnosis – A Qualitative Examination of Swedish Parents of Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Authors: Ringer Noam , Schön Ulla-Karin
Published: June 2024

Background: Pediatric acute-onset neuropsychiatric syndrome (PANS) is a symptom-based and clinically heterogeneous condition characterized by an abrupt and dramatic onset of symptoms such as loss of motoric and cognitive abilities, anxiety, compulsion, tics, and eating disorders. PANS is a new diagnosis and the condition has gathered controversy in research and clinical practice. Aim: We aimed to investigate the process by which parents of children with PANS acquire knowledge about the condition; the causes that lead parents to search for knowledge; the ways in which they search for knowledge; and the manner in which this knowledge is received by medical care professionals. Method: The study employed in-depth semi-structured, individual interviews with 13 parents of children diagnosed with PANS. An inductive qualitative thematic analysis was used as a guide for analyzing the data. Results: Challenges to understand their child’s illness and receive effective care led the parents to search for knowledge about PANS and provide an explanation for their child’s symptoms. They used personal and social resources to search for knowledge. They felt trusted and encouraged when clinicians endorsed their knowledge. On the other hand, when they were dismissed as a source of knowledge, they experienced a lack of trust towards professionals. Conclusions: A driving force for parents’ search for knowledge is a perceived incapacity to give meaning to their experiences. Another reason is mistrust of healthcare staff’s existing knowledge.
New insights on habitat use by larval Northern Emerald dragonflies (Somatochlora arctica)
Authors: Cristofaro Luigi , Batty Pat , Muir Daniele , Law Alan
Published: June 2024

Odonates are widely considered to be bioindicators of freshwater habitat quality. Somatochlora arctica (Corduliidae) is commonly found across Eurasia, predominantly in North and Central Europe, but in the UK, it has a restricted range and is listed as near threatened despite a large, potential habitat availability. Across their range, larvae are found in Sphagnum-filled bog pools near coniferous woodlands, but detailed data on their habitat requirements are limited and often overlooked in favour of adult surveys which inhibits conservation efforts. This study surveyed three areas across Scotland: Abernethy & Loch Garten National Nature Reserve (NNR), Beinn Eighe NNR and Flanders Moss NNR, to evaluate how different environmental factors per pool (e.g. water depth and chemistry, Sphagnum coverage, woodland distance, etc.) affect the presence of S. arctica larvae. We found a higher occurrence of S. arctica larvae when pools were located close to woodlands (i.e. 0–10 m), and had high coverage of Sphagnum (> 90%). Environmental variables in pools surveyed (i.e. conductivity, water depth, pH and water temperature) had no significant effects on S. arctica presence.

Implications for insect conservation: Our results highlight and discuss the importance of nearby woodlands and Sphagnum cover for S. arctica larvae. Future conservation projects should consider the proximity of woodland to current and restored S. arctica sites or promoting expansion of surrounding natural woodland patches to benefit S. arctica and potentially other odonates sharing similar ecological preferences.