bluuebunny/crossref_metadata_2025 huggingface dataset:
Los puntos ciegos de la transdisciplinariedad : una insuficiencia por subdisciplinariedad.
Authors: Bedoya Leguizamón Hector de León
Published: March 2020

En los escenarios académicos e investigativos ha venido abriéndose paso la transdisciplinariedad con las dificultades propias que trae la emersión de un paradigma revolucionario, trayendo consigo escollos de orden conceptual, epistemológico, metodológico y organizacional. Tratando de posicionarse en medio de un sistema científico jerarquizado, fragmentado, lineal, binomial y reduccionista; sin contar los influjos político, económico y cultural que afectan toda empresa. Pero este joven modelo de comprensión presenta en sus dinámicas intelectuales y operativas un problema de hondo calado: un hecho de carácter comportamental que ralentiza su progreso y que se sitúa en un nivel de realidad biológico primitivo en el que las comunidades educativas e investigativas poco reparan en sus dinámicas. Por tanto, se trata de un factor evolutivo que puede resultar muy sensible en la transdisciplinariedad, dado que esta nueva apuesta científica tiene como uno de sus mayores objetivos superar dicotomías y antagonismos en el conocimiento disciplinal para tener una comprensión más integral de la realidad, lo que amerita una lógica subyacente complementaria como la subdisciplinariedad. Razones por la cuales se ha dispuesto discurrir de la mano del pensamiento complejo, fundamentalmente desde la perspectiva de Edgar Morin y Basarab Nicolescu.
El cuento como estrategia pedagógica para desarrollar la capacidad de negociación en la solución de conflictos del alumno en edad preescolar.
Authors: Leyva Ortiz Jesus Alberto , Campos Patiño Norma Veronica
Published: March 2020

El interés del presente trabajo son las potencialidades inexploradas del alumno de educaciónpreescolar y, los recursos clásicos y contemporáneos inexplotados para este nivel educativo. Este artículo describe, analiza y expone los resultados al aplicar el cuento como una estrategia didáctica sistematizada que posibilita procesos de aprehensión al concepto de negociación y su uso en la resolución de conflictos en alumnos de 3º. de preescolar de la ciudad de San Luis Potosí. La selección minuciosa de una obra, su lectura y reflexión en el grupo focal fue el punto de partida de la investigación organizada en tres fases: exploración, identificación y concienciación. Los alumnos trabajaron bajo consignas fundamentales, desarrollaron procesos metacognitivos y colaboraron entre sí para la obtención de un fin común. A la luz del juicio de expertos entre otros instrumentos de validez y confiabilidad de datos se deja ver el impacto favorable de esta estrategia en el aprendizaje, la imperante necesidad de innovación en las prácticas pedagógicas actuales y los alcances del uso de un recurso tan cercano pero olvidado como lo es el cuento.
Dialogos en familia : una propuesta de soporte para construir una cultura de paz en Colombia.
Authors: Álvarez Álvarez Lucia , Marrugo Padilla Albeiro
Published: March 2020

El presente artículo muestra una propuesta construida como resultado del proyecto, Mi casa es escuela y mis padres maestros para ofrecer la Cátedra de la Paz, realizado en Cartagena de Indias, Colombia; dicha propuesta podrá servir de apoyo en la implementación del acuerdo con el grupo FARC, de tal manera que la familia pueda convertirse en uno de los actores que participan, direccionando el camino para construir una cultura de paz para la vivencia del post conflicto. El marco metodológico del proyecto es la Investigación Acción Participación, por lo cual es muy probable que el resultado obtenido, pueda ser adoptado e implementado por una comunidad voluntaria, con el fin de validar su impacto como apoyo en la mejora de las relaciones familiares con tributo en la convivencia en paz.
Experiencias campesinas por la paz : agricultura familiar y construcción de paz territorial en Colombia.
Authors: Rodríguez Prada Ángela , Quijano Mejia Claudia Milena , Rojas Betancur Héctor Mauricio
Published: March 2020

En este artículo se realiza un análisis sobre las condiciones sociales y productivas de las familias pertenecientes a tres asociaciones campesinas que surgen en el marco del conflicto armado, como propuestas comunitarias de resistencia pacífica y construcción de paz en Colombia. Los resultados cuantitativos de esta investigación se obtienen a través de un instrumento estructurado aplicado a 102 hogares pertenecientes a familias asociadas en el departamento de Santander y la zona del Magdalena Medio, seleccionados por muestreo aleatorio simple. Se destacan las ventajas sociales, educativas y productivas que estos modelos asociativos, surgidos como defensa ante el conflicto armado, brindan a sus familias y que pueden ser capitalizados como modelos productivos en el postconflicto. También se encontraron carencias en la asistencia estatal y dificultades en la formalización de la tenencia de la propiedad de la tierra y la comercialización de la producción.
Dicotomia entre los componentes objetivos y subjetivos de la seguridad personal : el caso de la red de ciudades como vamos, Colombia.
Authors: Salas Barón Eliana Esther , Mattos Meza Dimayda Karine , Maza Avila Francisco Javier
Published: March 2020

Este artículo centra su atención en la dicotomía existente entre los componentes objetivos y subjetivos de la seguridad personal. Para ello, se analizan las estadísticas de Homicidios, Victimización y la Percepción sobre seguridad personal de los habitantes de Barranquilla, Bogotá, Bucaramanga, Cali, Cartagena, Ibagué, Manizales, Medellín y Pereira, todas pertenecientes a la Red Colombiana de Ciudades Cómo Vamos, cuya misión consiste en analizar las percepciones que tienen los ciudadanos sobre diferentes aspectos de la ciudad -seguridad, movilidad, institucionalidad, entre otros-. Los resultados muestran que, a pesar de la reducción, en promedio, de las estadísticas asociadas a los homicidios y a la victimización en todas las ciudades analizadas, estos resultados poco o nada han logrado impactar en la percepción de sus habitantes.
ANALYSIS AND PREVENTION OF ADVERSE RESPONSES TO DRUGS USED IN DENTISTRY
Authors: Vlasova Natalia N. , Sologova S. S. , Tereshkina O. I. , Sochova I. A. , Chubarev V. N. , Prokhorov N. I. , Sologova D. I.
Published: March 2020

Drug preparations, a substance or a mixture of substances of synthetic or natural origin, are used for the prevention, diagnosis, and treatment of various diseases. Along with the benefits, drug prepararions can also have adverse side effects, identifying the causes of which is quite problematic in the practice of a dentist because of the diversity of the clinical picture. The rational use and optimal choice of a drug among a wide range of drugs depend on the profile of its effectiveness and safety, drug interaction, individual characteristics of the patient (genetic polymorphism), and other concomitant diseases. Nowadays, the practice of a dentist is impossible to imagine without the use of drugs. Drug preparations allow doctors providing quality medical care that meets international standards, but do not forget that when prescribing a drug is extremely important to consider how rationally and necessary to use it to achieve a positive result in treatment. Therefore, the study of the prevention of the development of unwanted adverse reactions of drugs in dentistry is an important topic that requires close attention. Based on the analysis of the literature on the RSCI, Scopus, Web of Science, MedLine databases, the most commonly prescribed groups of drugs in dentistry were found to be as follows: non-steroidal anti-inflammatory drugs (NSAIDs), topically anesthetizing, antimicrobial, antiseptic, and drugs. The aim of the study: On the basis of the analysis of modern information about undesirable reactions of drugs, often used in dentistry, to optimize approaches to rational use and prevention of undesirable side effects.
MATHEMATICAL MODELING OF THE DEVELOPMENT OF CHRONIC FLUORINE INTOXICATION IN ALUMINIUM INDUSTRY WORKERS
Authors: Budkar L. N. , Obukhova Tatyana Yu. , Solodushkin S. I. , Fedoruk A. A. , Shmonina O. G. , Karpova E. A.
Published: March 2020

Introduction. Chronic fluorine intoxication prevails among the newly discovered occupational diseases in aluminum industry workers. Mathematical modeling is one of the helpful tools in ensuring better risk management with respect to the development of occupational fluorosis. Objective. Developing a logistic regression model predicting a probability of occupational fluorosis development in an occupational staff of aluminum plants in order to suggest adequate prophylactic strategies. Material and methods. A logistic regression model predicting a probability of the development of occupational fluorosis in aluminum industry workers of the Sverdlovsk region was constructed. The model embraced the results of a univariate analysis conducted with respect to major occupational exposures and health characteristics of 201 workers. Results. Six major factors were identified as being predictive of occupational fluorosis development in aluminum industry workers: age (fluorosis risk increases with age); type 2 diabetes mellitus; atrophic gastritis; kidney cysts; X-ray examination data (fluorosis risk increases with the stage as determined by X-ray); the hydro fluoride concentration increases by more than 2 occupational exposure limits. The developed model was verified by clinical cases and showed a high predictive ability (86.2 %). Both sensitivity (true positive rate) and specificity (true negative rate) of the model amounted to 86.2 %. Conclusion. By multivariate analysis the significant, mutually independent factors were identified, their combination being associated with chronic fluorine intoxication in an occupational staff of aluminum plants. The developed mathematical model has a high predictive ability and can be recommended as a sure tool to forecast the course of occupational fluorosis development in the workers at the aluminum industry.
ADAPTIVE ABILITIES OF THE MEDICAL STAFF OF MATERNITY HOSPITALS
Authors: Kotelevets Elena P. , Kiryushin V. A. , Prohorov N. I. , Melnichenko P. I.
Published: March 2020

Introduction. The aim is scientific planning of preventive measures based on the assessment of adaptive capabilities of the organism of medical personnel of maternity institutions in the dynamics of the work shift. Material and methods. With cardiointervalogram variation of the studied indices of the cardiovascular and autonomous nervous system in obstetricians-gynecologists, neonatologists, nurses - midwives, nurses - anesthetists, ward nurses of perinatal centers and maternity hospitals in cities of Ryazan, Smolensk, Lipetsk, and Kolomna at the beginning and at the end of the work shifts. Results. The analysis of heart rate variability revealed significant statistical differences in a number of indices of the spectral region (the decline in values of sympatho-parasympathetic balance (LF/HF), the amplitude of very low-frequency waves (LFW), increase in the total power (TP), as well as an increase in the index of activity of regulatory systems (IARS) (p<0.05), established the relationship between the IARS at the end of the shift and the intensity of the labor process of obstetricians-gynecologists of perinatal centers, nurses-anesthetists, and midwives of perinatal centers. Conclusion. The revealed direct correlation between the IARS at the end of the work shift and the intensity of the labor process of obstetricians-gynecologists of perinatal centers, medical nurses-anesthetists, and midwives of perinatal centers confirms the results of hygienic studies of the labor process intensity and allows planning preventive measures.
Evaluaciónde OPS para la Reducción de la PAPR en un SistemaOFDM conCanal Multitrayecto
Authors: Peñaherrera María , Reinoso Diego
Published: March 2020

OFDM (Orthogonal Frequency Division Multiplexing) es una tecnología de comunicacióninalámbrica que tiene ventajas como alta eficiencia espectral, alta tasa de transmisión y es robusta a la propagación por mulitrayecto. Sin embargo, su principal desventaja es que tienealta PAPR (Peak-to-Average Power Ratio).Este artículo presenta la evaluaciónde la técnica OPS (Orthogonal Pilot Sequence) para la reducción de la PAPR en un sistema OFDM con canal multitrayecto. Para la evaluación se consideran dos tipos de canalesmultitrayecto selectivos en frecuencia, con y sin línea de vista. Se evalúa la técnica OPS obteniendola gráfica del BER (Bit Error Rate)vs Eb/No (energy per bit to noise power spectral density ratio) y la gráfica de la CCDF (Cumulative Complementary Distribution Function) para distintos parámetros. Losresultados muestran una reducción de la PAPR cuando se utiliza la técnica OPS y una mejora en el BER.
El liderazgo femenino como impulsor de la actividad emprendedora en la zona 3 del Ecuador
Authors: Gualán-Simbaña Luzmila , Lisintuña-Vinueza Lizette , Rivera-Badillo Pilar
Published: March 2020

Sin duda, el emprendedor se convierte en el mejor agente de cambio para el desarrollo económico de un país. En Ecuador la participación de las mujeres en el emprendimiento representa el 41%. Esta investigación tuvo como objetivo identificar las cualidades, motivaciones, limitaciones que poseen las mujeres emprendedoras de la zona 3 del Ecuador (Tungurahua, Chimborazo, Cotopaxi y Pastaza) registradas en el Directorio de empresas y establecimientos para reconocer su estilo de liderazgo. En la metodología utilizada participaron 308 mujeres emprendedoras de la zona 3 de los sectores económicos: Comercio; alojamiento y servicios de comida; otros servicios; manufactura; transporte; información y telecomunicaciones. El diseño de la investigación se desarrolló a través de un enfoque cualitativo y cuantitativo. La metodología aplicada es empírica, la técnica de investigación para recabar información primaria fue la entrevista y como instrumento la encuesta. Con los datos obtenidos se aplicó la prueba Tau b de Kendall. Entre los principales hallazgos se observó una estrecha relación entre cualidades: ímpetu y proactividad y las motivaciones: deseos de superación personal y generar propios ingresos. A pesar de tener haber tenido limitaciones como la falta de recursos financieros y el miedo al fracaso no se han visto impedidas de emprender. Sin embargo, las mujeres emprendedoras de la zona tres no se consideran líderes a pesar de tener competencias y valores propios de este atributo. A su vez se identificó como principal estilo el liderazgo de equipo. Se concluye que las mujeres de la zona motivo de estudio han crecido en un ambiente cultural que coarta su autoidentificación de liderazgo, sin embargo, estas mujeres son potencialmente líderes enfocadas en el crecimiento de la producción de sus empresas y sus equipos de trabajo.
Modelo de gestión Customer Relationship Management (CRM) para empresas de transporte en el Ecuador
Authors: Torres-Sánchez Angélica , Ormaza-Andrade Jorge , Erazo-Álvarez Juan , Farfán-Quezada Viviana
Published: March 2020

El presente artículo muestra un modelo de Gestión Customer Relationship Management (CRM) para Atrain microbuses buses Courier; el cual se desarrolló con el objetivo de mejorar el servicio al cliente para la empresa de transporte inter e intra provincial. Se aplicó una metodología con enfoque mixto, a través de los distintos métodos inductivo- deductivo, método histórico lógico, analítico – sintético debido al tratamiento de datos obtenidos mediante técnicas e instrumentos de recolección como la encuesta y la entrevista. La población de estudio estuvo representada por los clientes de la empresa, el objetivo de la documento investigativo es proponer un modelo de gestión Customer Relationship Management (CRM) que mejore el servicio y la atención al cliente para la empresa Atrain microbuses buses Courier. Los resultados dan cuenta que en la empresa existen diversas falencias con respecto al manejo de la fiabilidad por parte de los empleados, la seguridad y la tangibilidad. En donde se puede evidenciar que no se están cumpliendo con las promesas de venta, además de no poseer equipos modernizados; así como también, formas de pagos, escasa visualización de las instalaciones físicas, el personal no inspira confianza debido al carencia de interacción con el cliente; además, se demostró que las personas no tienen conocimientos de procesos en minimización de tiempo en la venta; por lo tanto se desarrolló una propuesta que tiene la peculiaridad de ser válida para empresas de transporte enfocadas en propiciar la retención de clientes a través de la mejora continua de servicio al consumidor, esto mediante el desarrollo de tres componentes principales que están relacionados al área operativa de la empresa, los cuales son: el área de servicio, área de marketing y el área de ventas.
Efektivitas Pembelajaran Bahasa Indonesia Bagi Penutur Asing di KBRI Finlandia
Authors: Mahmud Mahmud , Jaufillaili Jaufillaili
Published: March 2020

This study aims to investigate the effectiveness of Bahasa Indonesia for non native speakers teaching process in the Finland Embassy based on the students perception through survey method. This study means to give the descriptive information about the teaching process held in 2018. The subject of this research is all the participant of the BIPA program. The instrument of the research is Course Experience Questionnaire (CEQ) by Ramsden (1993) which includes; Teaching Quality, Generic Skills, Students motivation, Academic environment, Assessment, and Curriculum. The data is analyzed by using psicometric Likert scale. The result of the study show; Teaching Quality is categorized effective, Generic skills is categorized less effective, Students motivation is categorized effective, Academic environment is categorized quite effective, Assessment is categorized quite effective, and Curriculum is categorized not effective. Overall, the process of the BIPA teaching activity is categorized quite effective.
Analisis Hubungan antara Kesadaran Metakognitif dengan Hasil Belajar Matematika dan IPA Siswa SMA di Kota Mataram
Authors: Fitria Lia , Jamaluddin Jamaluddin , Artayasa I Putu
Published: March 2020

The purpose of this study was to investigate the relationship between metacognitive awareness with mathematics and science learning outcomes of high school students in the city of Mataram. This research is correlational research. Metacognitive awareness is measured by the Metacognitive Awareness Inventory. Student learning outcomes seen from the average value of report cards. The data analysis of this study used descriptive analysis and inferential statistical analysis through the product moment correlation test. The results of data analysis showed that 18.89% of students had metacognitive awareness in the excellent category; 80.31% with good category; and 0.78% in the medium category. Metacognitive awareness in each metacognition sub-component that has the highest score is the debugging strategy (79.74%) and the lowest is the evaluation sub-component (72.03%). Based on data analysis of students' mathematics and science learning outcomes it is known that the learning outcomes in the excellent category amounted to 70.47%. Student learning outcomes in the good category 29.25% and in the moderate category 0.78%. Hypothesis test results were performed using SPSS 16 with product moment correlation techniques obtained correlation coefficient r = 0.193 and the coefficient of determination R2 = 3.7%. The results of this hypothesis test indicate that there is a positive and significant correlation between metacognitive awareness and mathematics learning and science outcomes in high school students in the city of Mataram. The contribution of metacognitive awareness to mathematics and science learning outcomes of high school students was 3.7%.
Mindfulness Based Intervention To Increase Self-Disclosure In Broken Home Children
Authors: Bulantika Siti Zahra , Sa'adah Sa'adah , Sari Permata , Mafirja Sulma
Published: March 2020

The purpose of this study was to examine the effectiveness of mindfulness interventions in increasing self-disclosure in broken home children in MTS N 1 Bandar Lampung. This type of research is an experimental study with the Single Subject Research (SSR) method. The subject is 14 years old grade IX student. The research design used is multiple baseline A1-B-A2. The instrument used is a scale developed from Devito's theory, which includes five dimensions, namely amount, valence, accuracy/honesty, intention, and intimacy. The   study   used   interrater   reliability   to display  the  reliability  of  the  data  findings.The results showed an effective mindfulness intervention to increase self-disclosure in broken home children. The results of the study provide new knowledge about mindfulness interventions in broken home children to increase self-disclosure so that it can be a reference for other research or individual institutions in the provision or application of mindfulness to help improve self-disclosure.
Pendidikan Vokasi BTEC UK di Indonesia: Studi Fenomenologi Esensi Pengalaman Peserta Didik
Authors: Jang Johan , Purwanto Agus , Purnamasari Dian , Ramdan Mohamad , Hutagalung Leo , Akuba Stefy Falentino , Sulistiyadi Andi , Pramono Rudy , Bernarto Innocentius
Published: March 2020

Studying abroad, including in the United Kingdom is one of the aspirations for students and parents in Indonesia. In comparison to directly continuing study overseas, the availability of BTEC UK curriculum in Indonesia allows students to study for 20 months then continued their final year in the country they are planning to go to, including in the UK. Unfortunately, there is no record of the experience of students undergoing this curriculum in Indonesia, even though the curriculum already exists in Indonesia for more than ten years. This study then explores the motivations behind the decisions of students undergoing the BTEC curriculum in Indonesia, their experiences and the outcomes that occur after. Interviews with the 7 BTEC alumni in Indonesia were conducted and analyzed using qualitative phenomenology study. The results obtained that internal motivation is the main trigger whereas external motivation also applies, which is built up through social influence. The experience felt at the beginning was generally difficult to follow because the students were not used to the system, even though some felt excited about the curriculum learning system. In the middle and end of the semester, some of them feel more accustomed to it while some still find it difficult to follow this curriculum. The results in the form of a variety of positive attitudes including courage, self-confidence, and the development of communication skills.
Pengaruh Hard Skills, Soft Skills dan Mediasi Budaya Sekolah Terhadap Kapabilitas Inovasi Guru di Jawa Barat
Authors: Asbari Masduki , Purwanto Agus , Wijayanti Laksmi Mayesti , Hyun Choi Chi , Kusumaningsih Sekundina Williana , Yanthy Evy , Putra Firdaus , Winanti Winanti , Imelda Donna , Pramono Rudy , Bernarto Innocentius
Published: March 2020

This study aims to measure the effect of hard skills and soft skills on the innovation ability of the teachers in West Java which are mediated by organizational culture. The method used in this research is quantitative method. Data collection is done by simple random sampling via electronic to the teacher population in West Java. The results of the returned and valid questionnaire are 667 samples. Data processing using SEM method with SmartPLS 3.0 software. The results of this study concluded that hard skills and soft skills have a positive and significant effect on teacher innovation ability, both directly and indirectly through mediating organizational culture. This new research proposes a model to build innovation capabilities of the teachers among teachers in West Java through enhancing hard skills and soft skills with organizational culture as a mediator. This research can pave the way to increase teacher readiness in the face of the education 4.0.
Pengembangan Modul Praktikum Laboratorium Sekolah Tinggi Teknik Lingkungan (STTL) Mataram
Authors: Fatmalia Enida , Nurhidayatullah Nurhidayatullah
Published: March 2020

The purpose of this study is to find out the results of the development of practicum modules in STTL Mataram laboratories are based on a process skills approach. The procedure of practicum module development refers to the ADDIE learning development model. Data collection techniques were carried out by means of an assessment by 3 experts and limited trials on students in the even semester of the 2018/2019 academic year at D-3 Kesehatan Lingkungan of STTL Mataram with a sample of 30 people. The instruments used in this study were expert assessment questionnaire and student response questionnaire on the results of module development. Data analysis techniques use expert judgment categorization criteria, whereas limited trials use the average categorization of the results of trials using the Gutman scale calculation. The results showed that the score of expert assessment of the modules developed were (1) Module 1 semester 1 average score of 3.5 included in both categories with information can be used with a little revision; (2) Module 3 semester average score 3.5 is included in both categories with information can be used with a little revision; and (3) Module 5 semester average score 3.5 is included in both categories with information can be used with a little revision. While the limited test results show that the modules developed are included in the Good category but need to be improved and refined to be able to produce modules that are ready to be used in practicum.
Confrontation of nobles of Poland as a factor of exacerbating ethnosocial relations in Ukraine by the end of XVIth century – at the first half of XVIIth century
Authors: BOLIANOVSKYI Andrii
Published: March 2020

The author describes the main forms and manifestations of internal conflicts in the environment of noble families in the Ukrainian lands since their accession to Rzecz Pospolita as united Polish-Lithuanian state on the basis of the Union of Lublin in 1569 up to the War under the leadership of Bohdan Khmelnytskyi. According to author’s statements, permanent struggle among them was able to happen due to the specific of this state that garanted to reach Polish nobles the large rights. Long-time colonization of ‘Wild steppe’ was accompanied occasional ‘raider attacks’ of landowners against their neighbors. Particular emphasis is given to different situation of dependent peasants, which during these ‘local civil wars’ often did become ‘blind arms’ of their masters. The influence of these confrontations on the processes of the growth of protesting attitude among the Ukrainian gentry and peasantry and their influence on the rising of Cossack and peasant uprisings in Ukraine during abovementioned period are analyzed. The article contribute certainly to better understanding of disagreements in interests between often ethnically different social strata in Ukraine. Widespread of this confrontation provoked some anarchy of powerless inside the country as well as hostile situations between Polish and Ukrainian nobles. Cossack uprisings were results not only social conflicts between Polish gentry and Ukrainian peasantry, Orthodox Ukrainians and Rome-Catholic Poles, but also inter-strata conflicts among anti-Polish nobles and ‘loyal to Crown’ gentry of Poland. Conflicts after colonization of ‘Wild field’, as well as the value of personal insults of offended persons in provoking these conflicts are characterized. The accent is made that the assaults, violence and crimes were happened long time before Cossack-Polish conflicts. According to author’s conclusions, all these confrontations between different ethnic and social groups were transferred in a form the long-lasted wars of Cossacks and peasants against their former owners beginning from 1648.

Keywords
Rzeczpospolita, Ukraine, nobles, ethnosocial conflicts
Portrait of a specific place and time: from the diary entries of 1939 by Olha Dolhun
Authors: VOITIV Hanna
Published: March 2020

Is submitted the part of the diary Olha Dolhun (Hryniuk) (1914–1997), who lived in the Sokal city, located in the north of Lviv oblast on the border with Volyn. She was educated at the Teachers Seminary in Sokal. Her diary is a kind of private and public coverage of Sokal in 1939 against the backdrop of a major global shift ‑ the outbreak of World War II. The first entry in the diary was made on March 17, 1939, and the last ‑ on October 17. During this time, took place the proclamation of the Carpathian Ukraine, the Molotov-Ribbentrop Pact, the invasion the Hitler's Germany and the Soviet Union to Poland and the Soviet annexation of Eastern Galicia. The author has shown a remarkable ability to correctly evaluate events, determine in them the place of their nation and own place. Has been published the part of the diary, with separate fragments from August 24 (information about the signing of the Molotov-Ribbentrop Pact) to the beginning of October (the author's first impressions about the new Soviet regime).

In addition to global issues, the author draws attention to everyday life, social life, pre-war moods, national-patriotic orientation of Ukrainian youth. The diary is densely «populated» with multitude of Sokal people's names. The diary of Olha Dolhun, along with other examples of literature of this genre, make history alive, contribute to a deeper acquaintance of contemporary Ukrainians with the socio-cultural type of Galicia before and during the outbreak of World War II.

Keywords
Olha Dolhun, Sokal, Poland, Germany, Soviet Union, occupation.
Polish army and polish national policy in the Lwow, Stanisławow and Tarnopol voivodships in 1921–1926
Authors: OSTANEK Adam
Published: March 2020

Of all the citizens of the Second Polish Republic, 30 % were representatives of various national minorities. The Polish authorities, realizing that such a large percentage of national minorities concentrated in specific regions, can threaten the security of the state, are trying to pursue an appropriate national domestic policy. Its goal was to reduce this danger. The Polish army was one of the instruments that were used to varying degrees by the authorities. The purpose of the article is to show the place, role and tasks that the Polish army had to fulfill in relation to the national policy pursued in the southeastern voivodships of the Second Polish Republic in 1921–1926. The sources for publication is the then civil-military legal acts, archival materials collected in archives on the territory of Poland and Ukraine, as well as scientific research.

The author paid considerable attention to the measures of the military administration to neutralize the actions of the Organization of Ukrainian Nationalists, the Communist Party of Western Ukraine, the foreign intelligence agents (primarily from the USSR) in the military and civilian population of the Lviv, Stanislaviv and Ternopil voivodships which were under the control of the military structures of the District Corps Command No. VI «Lviv» and No. X «Przemysl». Almost 5.5 million people lived in these voivodships, of which 45.1% were Poles, 47.9% were Ukrainians, 6.4% were Jews, 0.65 were Germans, 0.1% were other nationalities.
The author claims that the military authorities were vigilant about the security and strengthening of the Polish state.

Keywords
Polish Army, the Second Polish Republic, national policy, Lwow Voivodeship, Stanisławow Voivodeship, Tarnopol Voivodeship.
Forced Exercise Increases Muscle Mass in EAE Despite Early Onset of Disability
Authors: PATEL D. I. , WHITE L. J. , LIRA V. A. , CRISWELL D. S.
Published: March 2020

We aimed to determine whether 10 days of treadmill exercise can increase skeletal muscle mass and intramuscular concentrations of brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in experimental autoimmune encephalomyelitis (EAE). Forty female Lewis rats were randomly assigned to either EAE sedentary (EAE-Sed), EAE exercise (EAE-Ex), Control sedentary (Con-Sed) and Control exercise (Con-Ex). Exercising animals completed a 10 day forced exercising training program. Hind limb skeletal muscles were excised and weighed with soleus muscle used for BDNF and NGF quantification. Statistical analysis was done using a one-way analysis of variance. Disability was more pronounced in the EAE-Ex group than in the EAE-Sed group. Exercising animals (EAE-Ex and Con-Ex) had significantly greater bilateral EDL, plantaris and gastrocnemius muscle mass compared to their sedentary animals (p=0.01). The EAE-Ex group had significantly higher NGF concentrations (1.98±0.3 pg/mg) compared to Con-Ex (0.96±0.07 pg/mg, p=0.003) and Con-Sed (1.2±0.2 pg/mg, p=0.04) groups. The main effect of exercise represented a significantly lower BDNF concentrations in the soleus of exercising animals compared to sedentary animals (p=0.03). Our study provides preliminary evidence that exercise increases skeletal muscle mass despite the early onset of disability in EAE animals.
Fatty Acid Profile in Erythrocyte Membranes and Plasma Phospholipids Affects Significantly the Extent of Inflammatory Response to Coronary Stent Implantation
Authors: ČERMÁK T. , MUŽÁKOVÁ V. , MATĚJKA J. , SKALICKÝ J. , LAŠTOVIČKA P. , LÍBALOVÁ M. , KANĎÁR R. , NOVOTNÝ V. , ČEGAN A.
Published: March 2020

In coronary heart disease, the treatment of significant stenosis by percutaneous coronary intervention (PCI) with stent implantation elicits local and systemic inflammatory responses. This study was aimed at evaluation of the dynamics of inflammatory response and elucidation of the relationship between the fatty acid profile of red blood cell (RBC) membranes or plasma phospholipids and inflammation after PCI. High-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), serum amyloid A (SAA), malondialdehyde (MDA) and the fatty acid profiles were determined in patients with advanced coronary artery disease undergoing PCI before, 24 h and 48 h after drug-eluting stent implantation (n=36). Patients after PCI exhibited a significant increase in studied markers (hsCRP, IL-6, SAA, MDA). Many significant associations were found between the increase of IL-6, resp. SAA and the amounts of n-6 polyunsaturated fatty acids (namely linoleic, dihomo-γ-linolenic, docosatetraenoic and docosapentaenoic acid), resp. saturated fatty acids (pentadecanoic, stearic, nonadecanoic) in erythrocyte membranes. The magnitude of the inflammatory response to PCI is related to erythrocyte membrane fatty acid profile, which seems to be a better potential predictor of elevation of inflammatory markers after PCI than plasma phospholipids.
Nitric Oxide Participates in IFN-γ-Induced HUVECs Hyperpermeability
Authors: NG C. T. , FONG L. Y. , LOW Y. Y. , BAN J. , HAKIM M. N. , AHMAD Z.
Published: March 2020

The endothelial barrier function is tightly controlled by a broad range of signaling cascades including nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway. It has been proposed that disturbances in NO and cGMP production could interfere with proper endothelial barrier function. In this study, we assessed the effect of interferon-gamma (IFN-γ), a pro-inflammatory cytokine, on NO and cGMP levels and examined the mechanisms by which NO and cGMP regulate the IFN-γ-mediated HUVECs hyperpermeability. The flux of fluorescein isothiocyanate-labeled dextran across cell monolayers was used to study the permeability of endothelial cells. Here, we found that IFN-γ significantly attenuated basal NO concentration and the increased NO levels supplied by a NO donor, sodium nitroprusside (SNP). Besides, application of IFN-γ also significantly attenuated both the basal cGMP concentration and the increased cGMP production donated by a cell permeable cGMP analogue, 8-bromo-cyclic GMP (8-Br-cGMP). In addition, exposure of the cell monolayer to IFN-γ significantly increased HUVECs basal permeability. However, L-NAME pretreatment did not suppress IFN-γ-induced HUVECs hyperpermeability. L-NAME pretreatment followed by SNP or SNP pretreatment partially reduced IFN-γ-induced HUVECs hyperpermeability. Pretreatment with a guanylate cyclase inhibitor, 6-anilino-5,8-quinolinedione (LY83583), led to a further increase in IFN-γ-induced HUVECs hyperpermeability. The findings suggest that the mechanism underlying IFN-γ-induced increased HUVECs permeability is partly related to the inhibition of NO production.
Baroreflex Sensitivity in Children and Adolescents: Physiology, Hypertension, Obesity, Diabetes Mellitus
Authors: HONZÍKOVÁ N. , ZÁVODNÁ E.
Published: March 2020

The increased prevalence of obesity in children and its complications have led to a greater interest in studying baroreflex sensitivity (BRS) in children. This review of BRS in children and adolescents includes subtopics on: 1. Resting values of BRS and their reproducibility, 2. Genetics of BRS, 3. The role of a primarily low BRS and obesity in the development of hypertension, and 4. Association of diabetes mellitus, BRS, and obesity. The conclusions specific to this age follow from this review: 1. The mean heart rate (HR) influences the measurement of BRS. Since the mean HR decreases during adolescence, HR should be taken into account. 2. A genetic dependency of BRS was found. 3. Low BRS values may precede pathological blood-pressure elevation in children with white-coat hypertension. We hypothesize that low BRS plays an active role in the emergence of hypertension in youth. A contribution of obesity to the development of hypertension was also found. We hypothesize that both factors, a primarily low BRS and obesity, are partially independent risk factors for hypertension in youths. 4. In diabetics, a low BRS compared to healthy children can be associated with insulin resistance. A reversibility of the BRS values could be possible after weight loss.
Increased Resting Energy Expenditure and Insulin Resistance in Male Patients With Moderate-to Severe Obstructive Sleep Apnoea
Authors: BRÚSIK M. , ŠTRBOVÁ Z. , PETRÁŠOVÁ D. , POBEHA P. , KUKLIŠOVÁ Z. , TKÁČOVÁ R. , JOPPA P.
Published: March 2020

Obstructive sleep apnoea (OSA) has been associated with disturbances in energy metabolism and insulin resistance, nevertheless, the links between OSA severity, resting energy expenditure (REE) and insulin resistance (homeostasis model assessment, HOMA-IR) remained unexplored. Therefore, we investigated the effects of OSA severity on REE, and relationships between REE and HOMA-IR in patients with OSA. Forty men [mean (SD) age 49.4 (11.4) years] underwent overnight polysomnography; REE was assessed using indirect calorimetry. REE adjusted for fat-free mass (FFM) was higher in patients with moderate-to severe OSA [n=24; body mass index (BMI) 31.1 (2.7) kg.m-2; apnoea-hypopnoea index (AHI)≥15 episodes.h 1] compared to participants with no clinically significant OSA (n=16; BMI 30.3 (2.2) kg.m-2; AHI<15 episodes.h-1) [median (interquartile range) 30.4 (26.1-31.3) versus 25.8 (24.6-27.3) kcal.kg-1.24 h-1, p=0.005)]. AHI and oxygen desaturation index (ODI) were directly related to REE/FFM (p=0.001; p<0.001, respectively) and to HOMA-IR (p<0.001 for both). In stepwise multiple linear models, REE/FFM was independently predicted by ODI (p<0.001) and age (p=0.028) (R2=0.346); HOMA-IR was independently predicted by ODI only (p<0.001, R2=0.457). In conclusion, male patients with moderate-to severe OSA have increased REE paralleled by impaired insulin sensitivity. Severity of nocturnal intermittent hypoxia reflected by ODI is an independent predictor of REE/FFM and HOMA-IR.
Evaluation of Cerebrovascular Reserve Capacity in Symptomatic and Asymptomatic Internal Carotid Stenosis With Transcranial Doppler
Authors: DOUVAS I. , MORIS D. , KARAOLANIS G. , BAKOYIANNIS C. , GEORGOPOULOS S.
Published: March 2020

Cerebrovascular reserve capacity (CVRC) is a hemodynamic parameter indicating the brain’s capacity to overcome ischemia. Transcranial Doppler (TCD) is a useful device to measure CVRC, with high availability and low cost. The aim of the study is to investigate asymptomatic patients with affected CVRC, who could benefit from CEA. One hundred and forty five consecutive patients (60 symptomatic and 65 asymptomatic), with internal carotid artery (ICA) stenosis >70 % and 20 healthy individuals without internal carotid stenosis underwent TCD-inhalation CO2 tests in order to measure the CVRC in both hemispheres of each patient. CVRC between asymptomatic and symptomatic patients were significantly different in the 95 % confidence interval (CI) as well as the mean CVRC value in contralateral carotid artery. The correlation between CVRC in the carotid artery with stenosis and the existence of symptoms is significant at the 0.01 level. Additionally, symptoms and CVRC of the contralateral carotid artery are also significant at the 0.05 level and CVRC values in asymptomatic patients and the control group at the 0.01 level. None of the covariant factors, except the age, are significantly correlated with CRVC. CVRC could be an early mark-index to evaluate the risk of stroke in this group of patients and to design their therapeutic approach.
Hepatotoxic Effects of Fenofibrate in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
Authors: ŠKOP V. , TRNOVSKÁ J. , OLIYARNYK O. , MARKOVÁ I. , MALÍNSKÁ H. , KAZDOVÁ L. , ZÍDEK V. , LANDA V. , MLEJNEK P. , ŠIMÁKOVÁ M. , KŮDELA M. , PRAVENEC M. , ŠILHAVÝ J.
Published: March 2020

Dyslipidemia and inflammation play an important role in the pathogenesis of cardiovascular and liver disease. Fenofibrate has a well-known efficacy to reduce cholesterol and triglycerides. Combination with statins can ameliorate hypolipidemic and anti-inflammatory effects of fibrates. In the current study, we tested the anti-inflammatory and metabolic effects of fenofibrate alone and in combination with rosuvastatin in a model of inflammation and metabolic syndrome, using spontaneously hypertensive rats expressing the human C-reactive protein transgene (SHR-CRP transgenic rats). SHR-CRP rats treated with fenofibrate alone (100 mg/kg body weight) or in combination with rosuvastatin (20 mg/kg body weight) vs. SHR-CRP untreated controls showed increased levels of proinflammatory marker IL6, increased concentrations of ALT, AST and ALP, increased oxidative stress in the liver and necrotic changes of the liver. In addition, SHR-CRP rats treated with fenofibrate, or with fenofibrate combined with rosuvastatin vs. untreated controls, exhibited increased serum triglycerides and reduced HDL cholesterol, as well as reduced hepatic triglyceride, cholesterol and glycogen concentrations. These findings suggest that in the presence of high levels of human CRP, fenofibrate can induce liver damage even in combination with rosuvastatin. Accordingly, these results caution against the possible hepatotoxic effects of fenofibrate in patients with high levels of CRP.
Porcine Dorsal Root Ganglia Ovarian Neurons Are Affected by Long Lasting Testosterone Treatment
Authors: JANA B. , PALUS K. , MELLER K. , CAŁKA J.
Published: March 2020

We studied the effect of testosterone overdose on the number, distribution and chemical coding of ovarian neurons in the dorsal root ganglia (DRGs) in pigs. On day 3 of the estrous cycle, the ovaries of both the control and experimental gilts were injected with retrograde tracer Fast Blue. From day 4 of the estrous cycle to the expected day 20 of the second studied cycle, the experimental gilts were injected with testosterone, while the control gilts received oil. After the completion of the protocol the Th16-L5 DRGs were collected. Injections of testosterone increased the testosterone (~3.5 fold) and estradiol-17β (~1.6 fold) levels in the peripheral blood, and reduced the following in the DRGs: the total number of the Fast Blue-positive perikarya, the population of perikarya in the L2-L4 ganglia, and the numbers of SP+/CGRP+, SP+/PACAP+, SP+/nNOS+ and SP-/nNOS+ perikarya. In the testosterone-injected gilts, the populations of SP+/CGRP-, small and large androgen receptors-expressing perikarya were increased. These results suggest that elevated androgen levels during pathological states may regulate the transmission of sensory modalities from the ovary to the spinal cord, and antidromic regulation of the ovarian functions.
Effect of Ginsenoside Rh-2 via Activation of Caspase-3 and Bcl-2-Insensitive Pathway in Ovarian Cancer Cells
Authors: KIM J. H. , CHOI J.-S.
Published: March 2020

Ginsenoside has been reported to have therapeutic effects for some types of cancer, but its effect on ovarian cancer cells has not been evaluated. In this study, we monitored the effects of ginsenoside-Rh2 (Rh2) on the inhibition of cell proliferation and the apoptotic process in the ovarian cancer cell line SKOV3 using an MTT assay and TUNEL assay. We found that Rh2 inhibited cell proliferation and significantly induced apoptosis. We confirmed the apoptotic effects of Rh2 using western blot analysis of apoptosis-related proteins. Specifically, the levels of cleaved poly ADP ribose polymerase (PARP) and cleaved caspase-3 significantly increased in SKOV3 cells treated with Rh2. Therefore, Rh2 clearly suppressed the growth of SKOV3 cells in vitro, which was associated with induction of the apoptosis pathway. Moreover, the migration assay showed that Rh2 inhibited the invasive ability of SKOV3 cells. Taken together, our results suggest that Rh2 has anticancer effects in SKOV3 cells through inhibition of cell proliferation and induction of apoptosis. Considering the therapeutic potential of Rh2, more studies should be carried out to facilitate the future application of this natural product as a potential anti-cancer agent.
Pengembangan Media Belajar Berbasis Desktop untuk Mengenal Kearifan Lokal dan Destinasi Wisata Kalimantan Selatan
Authors: Ahmad Ahmad , Yuliana Kenti , Zulkarnain M. Rizki
Published: March 2020

Kearifan lokal adalah modal masyarakat untuk memadukan aspek kelestarian alam dengan aspek perekonomian. Potensi yang banyak dimiliki daerah di Indonesia adalah potensi alam, karena keindahan dan keunikannya dapat dikembangkan. Dengan memperkenalkan destinasi wisata yang dimiliki Kalimantan Selatan, maka akan berdampak baik terhadap daerah tersebut dan masuk dalam daftar rencana tujuan wisata, menciptakan lapangan kerja dan meningkatnya perekonomian daerah setempat (Kelurahan, desa, kecamatan, kabupaten, provinsi). Berdasarkan latar belakang tersebut, maka tujuan dalam penelitian ini adalah mengembangkan media belajar mandiri berbasis desktop untuk mengenal kearifan lokal dan destinasi wisata Kalimantan Selatan agar layak digunakan sebagai media untuk lebih memperkenalkan wisata yang ada di Kalimantan Selatan. Penelitian yang digunakan adalah Penelitian dan Pengembangan (Research and Development/R&D) dengan mengadaptasi model Alessi & Trollip yang terdiri dari 3 tahap yaitu: planning (perencanaan), design (perancangan) dan development (pengembangan). Instrumen pengumpulan data yang digunakan adalah lembar validasi ahli materi, ahli media, uji coba perorangan, dan uji coba lapangan. Hasil dari penelitian ini adalah Penilaian ahli materi rata-rata 4,4 dengan kategori “Sangat Baik”. Penilaian ahli media rata-rata 4,13 dengan kategori “Sangat Baik”. Penilaian uji coba perorangan rata-rata 4,75 dengan kategori “Sangat Baik”. Penilaian uji coba lapangan rata-rata skor 4,45 dengan kategori “Sangat Baik”. Kesimpulan dari penelitian ini adalah dihasilkannya sebuah media belajar yang layak untuk digunakan sebagai media pengenalan wisata yang ada di Kalimantan Selatan.