bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential Mechanism by which Eriodictyol Protects against Doxorubicininduced
Cardiotoxicity based on Network Pharmacology, Molecular
Docking, and Molecular Dynamics Simulation
Authors: Qin Chunmeng , Sun Mei , Lv Feng , Du Dan , Li Wenjun , Liu Songqing
Published: June 2024

Background:

The clinical use of doxorubicin (DOX), an anthracycline antibiotic
with broad-spectrum applications against various malignant tumors, is limited by doxorubicininduced
cardiotoxicity (DIC). Eriodictyol (ERD) has shown cardioprotective effects, but the
mechanism of its protective effect on DIC remains unknown.

Aims:

This study aimed to explore the potential mechanisms by which ERD confers protection
against DIC.

Methods:

ERD and DIC targets were identified from the TCMSP, PharmMaper, SwissTargetPrediction,
TargetNet, BATMAN, GeneCards, and PharmGKB databases. Differential gene
expression data between DIC and normal tissues were extracted from the GEO database. A protein‒
protein interaction (PPI) network of the intersecting ERD-DIC targets was constructed using
the STRING platform and visualized with Cytoscape 3.10.0 software. Gene Ontology (GO)
functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway
enrichment analysis for ERD-DIC cross-targets were conducted. Validation included molecular
docking with AutoDock Tools software and molecular dynamics simulations with
Gromacs 2019.6 software.

Results:

Network pharmacology analysis revealed 43 intersecting ERD-DIC targets, including 6
key targets. GO functional enrichment analysis indicated that the intersecting targets were enriched
in 550 biological processes, 45 cell components, and 41 molecular functions. KEGG
pathway enrichment analysis identified 114 enriched signaling pathways. Molecular docking
revealed a strong binding affinity between ERD and 6 key targets, as well as multiple targets
within the ROS pathway. Molecular dynamics simulations indicated that ERD has favorable
binding with 3 crucial targets.

Conclusion:

The systematic network pharmacology analysis suggests that ERD may mitigate
DIC through multiple targets and pathways, with the ROS pathway potentially playing a crucial
role. These findings provide a reference for foundational research and clinical applications of
ERD in treating DIC.

conclusion:

Systematic network pharmacology analysis suggests that ERD may mitigate DIC through multiple targets and pathways, with the ROS pathway potentially playing a crucial role. These findings provide references for foundational research and clinical applications of ERD in treating DIC.
Arsenic Trioxide Suppresses Angiogenesis in Non-small Cell Lung Cancer via the Nrf2-IL-33 Signaling Pathway
Authors: Wang Mingdong , Yin Jizhong , Han Qianyu , Li Bing , Zhao Xue-Wei , Xue Lei
Published: June 2024

Background:

Non-Small Cell Lung Cancer (NSCLC) ranks as a leading cause of cancer-related mortality,
necessitating the urgent search for cost-effective and efficient anti-NSCLC drugs. Our preliminary research
has demonstrated that arsenic trioxide (ATO) significantly inhibits NSCLC angiogenesis, exerting anti-tumor
effects. In conjunction with existing literature reports, the Nrf2-IL-33 pathway is emerging as a novel mechanism
in NSCLC angiogenesis.

Objective:

This study aimed to elucidate whether ATO can inhibit NSCLC angiogenesis through the Nrf2-IL-33
pathway.

Methods:

Immunohistochemistry was employed to assess the expression of Nrf2, IL-33, and CD31 in tumor
tissues from patients with NSCLC. DETA-NONOate was used as a nitric oxide (NO) donor to mimic high levels
of NO in the tumor microenvironment. Western blot, quantitative real-time PCR, and enzyme-linked immunosorbent
assay were utilized to evaluate the expression of Nrf2 and IL-33 in the NCI-H1299 cell line. Subcutaneous
xenograft models were established in nude mice by implanting NCI-H1299 cells to assess the anti-tumor
efficacy of ATO.

Results:

High expression levels of Nrf2 and IL-33 were observed in tumor samples from patients with NSCLC,
and Nrf2 expression positively correlated with microvascular density in NSCLC. In vitro, NO (released from
1mM DETA-NONOate) promoted activation of the Nrf2-IL-33 signaling pathway in NCI-H1299 cells, which
was reversed by ATO. Additionally, both Nrf2 deficiency and ATO treatment significantly attenuated NOinduced
IL-33 expression. In vivo, both ATO and the Nrf2 inhibitor ML385 demonstrated significant inhibitory
effects on angiogenesis tumor growth.

Conclusion:

Nrf2-IL-33 signaling is usually activated in NSCLC and positively correlates with tumor angiogenesis.
ATO effectively disrupts the activation of the Nrf2-IL-33 pathway in NSCLC and thus inhibits angiogenesis,
suggesting its potential as an anti-angiogenic agent for use in the treatment of NSCLC.
Open Innovation or Traditional Patenting Strategies to Efficiently Address Health Emergencies: How Patent Information was used Towards Effective Treatments for COVID-19
Authors: de Almeida Tatiana Duque Martins Ertner , Cordeiro Diericon Sousa
Published: June 2024

Introduction/Objective:

During the 1150 days of COVID-19 pandemic there
were great efforts to develop efficient treatments for the disease. After this long time,
some drugs emerged as treatment for COVID-19. Some of them are new drugs, most of
them, known drugs. These developments were triggered by information already available
in patent documents. Pharmaceutical companies, therefore, rushed to conduct drugs evaluations
and trials in order to deliver to the world a reasonable treatment that could reach
the majority of its population. However, it is not immediately clear how companies operated
to reach their goals. The ability of open innovation to achieve results assertively and
faster than closed innovation strategies is questioned and therefore, it is questioned
whether pharmaceutical companies use open innovation to face COVID-19.

Methods:

In this work, data available on patent databases were mined to inform about
the scientific and technological panorama of selected drugs tested for COVID-19 treatment
and to understand the perspectives of such developments during the pandemic.

Results:

This study evidenced that most treatments were based on known drugs, that
some of the initially promising drugs were abandoned during the pandemic, and that it
was able to inform if open innovation and collaborations were explored strategies.

Conclusion:

This study evidenced that the developments during COVID-19 were not
based on open innovation by revealing a patent race towards the treatment development,
but with practically no collaborations or information exchange between companies, universities,
and research facilities.
Corrigendum to: Effects of Long Noncoding RNA AK093407 on the Biological
Behavior of Colon Cancer Cells and the Underlying Mechanism
Authors: Xuerong Zhao , Ao Sun , Jianping Wang , Xin Zheng , Duoduo Tian , Mingjuan Wang , Lijun Xiao , Enhong Zhao , Cui Zheng-Guo
Published: June 2024

The funding details have been incorporated upon author’s request in the funding section of this article entitled “Effects of Long
Noncoding RNA AK093407 on the Biological Behavior of Colon Cancer Cells and the Underlying Mechanism,” 2023, 26(2),
289-300 [1].

Details of the error and a correction are provided here.

Original:

This work was supported by the important project of the Hebei Province education department (ZD20180004, QN2016017,
QN2020208), Hebei Province population and family planning commission technological project (20160009), Chengde Medical
University project (202014, 201806).

Corrected:

This work was supported by The Natural Science Research Youth Fund for Higher Education of Hebei Province (QN2020208),
the Hebei Province population and family planning commission technological project (20160009), Chengde Medical University
project (202014, 201806), Key Discipline of College and Universities in Hebei Province, China ([2013]04), Technology Innovation
Guidance Project-Science and Technology Work Conference (Hebei Provincial Department of Science and Technology).

We regret the error and apologize to readers.

The original article can be found online at www.eurekaselect.com/article/122378.
The State of Nationalism (SoN): Nationalism and Capitalism
Authors: Basta Karlo
Published: June 2024

While the scholarship on the role capitalism played in the genesis of nationalism is relatively coherent, our understanding of the relationship between those two phenomena once they have emerged is much more disjointed. Are capitalism and nationalism inherently conflictual or is their relationship a symbiotic one? Under what conditions is one of those two patterns more likely? Clues about this dimension of the link between capitalism and nationalism are not readily available in existing accounts of either phenomenon. The goal of this article, therefore, is to cull and systematize various strands of ideas about how these two phenomena might be connected.
Teacher identity, Islamic behaviour and project-based learning methods for madrasah teacher: A phenomenological approach
Authors: Zamsiswaya Zamsiswaya , Mounadil Abdelaziz Ibrahim , Abdel-Latief Sara
Published: June 2024

A project-based learning method is required for the development of students' scientific thinking in the field of akidah akhlak (moral theology). This study takes a phenomenological approach to investigate the role of Islamic behavior and identity in the development of project-based learning methods, involving twenty moral theology teachers and conducting in-depth interviews to reveal the narrative of teachers' practice in using project-based learning methods. Thematic analysis of 20 teachers' two-group interviews revealed that teachers' personal beliefs provided a religiously motivated narrative framework that aided in the interpretation of one's experiences. Individual Islamic behavior, religiosity, and identity creativity play a role in developing project-based learning methods for moral theology. In addition to attributing creativity from God-given personality to learning in moral theology, the primary bond in developing project-based learning methods is the application of Islamic principles and Islamic behavior. Following the learning of moral theology, students' identities, Islamic behavior, and scientific thinking develop. Finally, the findings of this exploratory study indicate that Islamic behavior and personal identity can enhance project-based learning methods. Large-scale research could provide more evidence in the future to reconsider the role of religious education in teacher training as an essential factor in developing project-based learning methods for moral theology teachers.
The influence of managerial competence and achievement motivation on the leadership effectiveness of high school principals in Medan city
Authors: Daulay Basyaruddin , Haidir Haidir , Firmansyah Firmansyah
Published: June 2024

This study aims to identify the influence of managerial competence and achievement motivation on the leadership effectiveness of high school principals in Medan City. In this study, the population used amounted to 231 people and the sample selected was 144 people using the Cochran formula. Questionnaires with Likert scale are used as data collection tools. Path analysis is used to analyze research data. The results of the analysis showed that managerial competence and achievement motivation had a significant direct influence on leadership effectiveness, with path coefficients of 0.164 and 0.189 respectively. These findings suggest that to improve the leadership effectiveness of principals, measurable efforts are needed, focusing on improving managerial competence and achievement motivation, which are important factors influencing effective leadership.
The differences of learning outcomes in students archery skill according to physiological ability
Authors: Widiyanto Widiyanto , Setyawan Hendra , Suharjana Suharjana , García-Jiménez José Vicente , Pavlovic Ratko , Nowak Agnieszka Magdalena , Susanto Nugroho , Gusliana-HB Gusliana-HB , Bin Shahri Mohd Izwan
Published: June 2024

This study aimed to determine the learning outcomes of students' archery skills in terms of physiological ability factors in the results of the initial, mid, and final shots. This is comparative quantitative research to determine the extent of variation or differences between related variables. Data analysis in this study used descriptive statistics and inferential one-way ANOVA. The research sample was students of the FIK PJKR study program class of 2019/2020. The result of the one-way ANOVA test is the Sig. 0.003 0.05 means there is no difference in the results of the middle and final shots. The results conclude no significant difference between the two variants in the average shot yield (browse). This study concluded that physiological ability factors contributed to archery skills, including cardiovascular endurance, muscle strength, respiratory tract, blood pressure, dehydration, etc.
Effect of an App-based Physiotherapeutic Exercise Regimen on Early Postoperative Compliance after Total Kneec Arthroplasty, Protocol of A Randomized Control Trial (Preprint)
Authors: Hakam Hassan Tarek , Hofmann Hannes , Lettner Jonathan , Ramadanov Nikolai , Salzmann Mikhail , Prill Robert , Becker Roland
Published: June 2024

BACKGROUND

Early postoperative physiotherapy following total knee arthrosplasty (TKA) has been demonstrated to improve patient-related outcomes. However, some studies suggest 50% of TKA patients are not active enough to maintain their physical health. Mobile applications have been reported to be as effective as face to face rehabilitation in prior systematic reviews.

OBJECTIVE

In the protocol at hand, a detailed description of the action plan regarding a randomized controlled trial (RCT) investigating the effect of a mobile reminder application on adherence to physical therapy and patient related outcome will be presented.

METHODS

This monocentric RCT is carried out at the University Clinic of Brandenburg. Patients between the ages of 55 and 80 with an indication for TKA are recruited during the first outpatient visit. Patients are then randomized into two groups. The treatment group is supplemented with the app-based physical therapy program while the controllers receive a paper-based program in accordance to the standard of procedure. Objective adherence to physical therapy is recorded using accelometry-based sensors. Additionally, patient-reported outcome measures (PROMs) and relevant performance-based measures (PBMs) are noted. The hypothesis of the study is that app-based physical therapy leads to higher compliance than a paper-based approach. Finally, a previously developped non-compliance questionnaire helps uncover the reasons behind non-adherence to physical therapy.

RESULTS

The primary outcome of this study is sensor-recorded compliance with physical therapy. Secondary outcomes includes the analysis of factors affecting compliance, patient-related outcome measures (PROMs), and patient-based measures (PBMs).

CONCLUSIONS

Compliance with a physical intervention is classically measured using questionnaires. The novelity of this study lies in the fact that adherence to the intervention is measured objectively using accelometers. As well, to our knowledge, no previous trial assessed a correlation between the degree of compliance to physical therapy on one hand and patient-related or performance-based measures. In the light of what was mentioned, this study might offer insights into regarding the extent to whch postoperative physical therapy has an effect on the postoperative outcome.

CLINICALTRIAL

The trial was registered at the Deutsches Register klinischer Studien. Registration number: DRKS00031414
Artificial patients in anesthesia: more than a passing fad? (Preprint)
Authors: Ferré Fabrice , Allassonnière Stéphanie , Chadebec Clément , Minville Vincent
Published: June 2024

UNSTRUCTURED

Artificial patients’ technology has the potential to transform healthcare by improving and potentially accelerating diagnosis and treatment, and by mapping clinical pathways or patient care processes. Deep learning methods for generating artificial data in healthcare include data augmentation by variational autoencoders (VAE) technology. The aim of our study was to test the feasibility of generating artificial patients with reliable clinical characteristics by using a geometry-based VAE applied, for the first time, on high dimension low sample size tabular data. Real patients’ tabular data were extracted from the “MAX” digital conversational agent created for preparing patients for anesthesia (BOTdesign®, Toulouse, France). A 3-stage methodological approach was implemented to generate up to 10,000 artificial patients: training the model and generating artificial data, assessing the consistency and confidentiality of artificial data, and validating the plausibility of the newly created artificial patients. We demonstrated for the first time the feasibility to transpose the VAE technique from imaging to tabular data for the generation of a large number of artificial patients. Our digital patients’ cohort was highly consistent. Moreover, artificial patients could not be matched with real patients, thus guaranteeing the essential ethical concern of confidentiality. Further studies integrating dynamic changes (and their variability) are needed to map trends and identify patient trajectories.
Digital health intervention effect on older adults with chronic diseases living alone: Systematic literature review and meta-analysis (Preprint)
Authors: Lee Munjae , Park Sewon , Kim Eun-Ji , Park Yoonseo
Published: June 2024

BACKGROUND

The incidence of chronic diseases is increasing owing to the aging population; in particular, older adults living alone struggle with self-management and medical expenses. Digital health can contribute to medical cost management and health promotion, but its effectiveness for older adults living alone remains unclear. In a rapidly aging society, it is important to demonstrate the effect of digital health on improving the lives of older adults living alone and reducing the burden of chronic diseases.

OBJECTIVE

This study was a systematic literature review and meta-analysis to confirm the effects of digital health interventions on self-management, quality of life, and medical factors for older adults with chronic diseases living alone.

METHODS

PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Cochrane CENTRAL electronic databases were used for literature published abroad and listed in journals until October 2023. The final 11 papers were used for analysis based on selection and exclusion criteria. Meta-analysis was employed to calculate the mean difference and standardized mean difference (SMD) for the selected literature using RevMan 5.4. The effect size and heterogeneity were calculated through 95% confidence interval.

RESULTS

As a result of conducting a meta-analysis of 8 out of 11 documents, there was a significant effect of self-management factors on moderate-to-vigorous physical activity (SMD = 0.08, Z = 2.07, P =.04). However, among self-management factors, LDL-cholesterol (SMD = -0.04, Z = 0.91, P =.36) did not show statistically significant results. Among the medical factors, general quality of life (SMD = 0.11, Z = 0.93, P =.35), depression (SMD = -3.95, Z = 1.59, P =.11), and hospital days (SMD = -1.57, Z = 0.91, P =.36) also did not show statistically significant results. However, it was confirmed that they improved after digital health intervention.

CONCLUSIONS

This study demonstrated that digital health interventions are effective in improving physical activity in older adults with chronic diseases living alone. However, owing to the characteristics of older adults living alone, there is a need to further expand digital health to combine care services that can manage diseases at home.

CLINICALTRIAL

Published data were used in this study and in the preparation of this paper; hence no ethical approval was required.

INTERNATIONAL REGISTERED REPORT

RR2-
Alternative approach to measure the Brazilian municipal development: the Relative Municipal Development Index
Authors: Gonçalves Mendes Barbosa Francis Régis , Schlindwein Madalena Maria , Corrêa da Silva Marcelo
Published: June 2024

Amartya Sen's theory of Development as Freedom states the prediction of development by evaluating the expansion of individual freedoms. This study operationalizes this theory and its instrumental freedoms through the construction of a development index and multivariate statistics. Spatiality of municipal development provides empirical evidence for interrelations between instrumental freedoms defended by this theory. The determinants of development related mainly to income and its distribution, but also housing conditions and social vulnerabilities. The findings unmask the geographic structure of (under) development in a frontier in Mid-West Brazil, marked by higher deprivation of opportunities, precarious services and greater economic stagnation.
Pembangunan WhatsApp Chatbot sebagai layanan kecerdasan buatan di Perpustakaan UIN Walisongo Semarang
Authors: Ahwan Muh Ahlis , Abiadhoh Nutfatin , Kusuma Alan Budi , Alam Umar Falahul
Published: June 2024

Introduction. This research aims to explore WhatsApp Chatbot as an artificial intelligence service at the UIN Walisongo Library.
Data Collection Methods. The method used is R&D with the Waterfall model from Roger S. Pressman starting from the stages of communication, planning, modeling, construction, to deployment. To build a WhatsApp Chatbot system dialog, data collection processes were conducted  using observations, interviews, questionnaires and documentation.
Data Analysis. The data was analyzed using descriptive qualitative. Further, the validity of the data was tested by triangulation of sources and techniques.  
Results and Discussion. WhatsApp Chatbot at UIN Walisongo Library was developed in five stages. They are communicating, planning, modeling, manufacturing and deploying. Information mapping is devided into Admin, Member, and General levels. WhatsApp Chatbot is integrated with SLiMS to produce dynamic and static answer obtained from librarian responses.
Conclusion. WhatsApp Chatbot becomes a solution for librarians and an alternative for library users at UIN Walisongo Library. It is expected that the WhatsApp Chatbot can also be integrated with other systems in the library so that integrated information can provide more complete information to meet the needs of library users.
Tantangan utama preservasi naskah kuno berbasis digitisasi
Authors: Makmur Testiani , Abdurahman Dudung , Zulaikha Sri Rohyanti , Samsudin Dafrizal
Published: June 2024

Introduction. This research aims to determine the main challenges in preserving ancient manuscripts based on digitization.
Research methods. This study used descriptive qualitative method. Data was obtained through literature studies based on scientific works published from 2013 to 2023. A total of 76 scientific works consisting of theses, national and international journals were obtained from the Google Scholar database with the keywords Naskah Kuno”, “Pelestarian Naskah Kuno”, “digitisasi naskah kuno.” Meanwhile in English it is like "Ancient Manuscripts, Preservation of Ancient Manuscripts, and digitization of ancient manuscripts.
Results and Discussion. Digitized preservation of ancient manuscripts requires careful budget planning and there must be a third party willing to sponsor it on an ongoing basis. Human resources working in the field of ancient manuscript preservation must understand the factors that cause damage to ancient manuscripts; not phobic of technology; awareness to learn about the use of technology; and ready to improve technology skills. The results of digitizing ancient manuscripts are guaranteed to be accessible in their entirety as mandated by law. Avoiding technological obsolescence requires paying attention to the age of the media so that there is a guarantee of long-term use.
Conclusion. This study shows five main challenges in the process of digitizing ancient manuscript preservation, including aspects of budget, policy, human resources, accessibility and technological obsolescence. In the future, preserving ancient manuscripts through digitization must focus on these five aspects, because they are interrelated.
Research on Enhancement of Gov't Functions in Regional Tech Achievements Transformation
Authors: Chi Zhenyu
Published: June 2024

The transformation of regional scientific and technological achievements is an important process of converting scientific research achievements into real productive forces, and the uneven distribution of regional resources is an inevitable problem in cross-regional innovation cooperation. To make up for the gap in scientific and technological resources, the cross-regional flow of technology has become an inevitable trend. While giving full play to the role of the market in resource allocation, it is even more necessary to give full play to the leading role of the government. With the introduction of a series of relevant laws and policies in China, the function of the government in the cross-regional transformation of scientific and technological achievements has been increasingly enhanced, but in this process, there are still deficiencies in the government's role positioning, relevant policies for interest balance, and the inter-governmental cooperation mechanism among regions. Based on this, it is necessary to optimize the function of the government in the transformation of regional scientific and technological achievements, effectively play the leading role of the government, construct an efficient and collaborative scientific and technological transformation mechanism, and cultivate the cooperation awareness of various participating subjects, so as to provide useful thinking for improving the function of the government in regional scientific and technological transformation.
Improving Cyber Security: Artificial Intelligence’s Ability to Detect and Stop Threats
Authors: Laxmi Subha , Kumar Satish
Published: June 2024

Artificial intelligence has become a crucial element of cyber security because of its capacity to assess security threats instantly and respond appropriately. Nowadays, AI plays a more significant role in identifying and thwarting attacks that keep companies innovative. The primary goals of artificial intelligence in cybersecurity are threat identification and mitigation. Artificial intelligence uses machine learning algorithms and sophisticated data analysis to identify patterns and abnormalities in user behavior and network traffic that can point to a possible cyberattack. Artificial Intelligence can help stop attacks by using predictive modeling. AI is also capable of anticipating dangers and preventing them by analyzing historical attacks and finding patterns. Automated incident response system creation is just another crucial cybersecurity use of artificial intelligence. These systems can assess data, spot possible threats, and then take action to lessen the impact of the attack by containing it or mitigating its effects. Artificial intelligence must be used by businesses in cybersecurity to safeguard their networks and sensitive data against ever-evolving online threats. Artificial intelligence (AI) is quickly emerging as a crucial tool for effective cybersecurity in today's digital environment due to its capacity to evaluate massive volumes of data in real-time and automate incident response. The importance of artificial intelligence (AI) in cybersecurity, particularly its applications in threat identification and defense.
The Impact of Patent Law on Sustainable Development
Authors: Enoch Otim
Published: June 2024

This article explores the complex relationship between patent law and sustainable development, highlighting the potential for patents to both promote and hinder progress towards a more sustainable future. The study examines how patent law can incentivize innovation and investment in sustainable technologies, while also considering how patents can create barriers to access and dissemination of these technologies. The article also discusses the role of patent law in promoting global cooperation and technology transfer, as well as the potential for alternative approaches to intellectual property protection to better support sustainable development goals. Through a comprehensive analysis of the literature and real-world case studies, the article provides a nuanced understanding of how patent law can impact sustainable development and offers recommendations for policymakers seeking to balance the interests of inventors and society as a whole.
Reconocimiento de nanomateriales por el sistema inmunológico
Authors: López Rodríguez Salma , Juárez Moreno Karla Oyuky
Published: June 2024

Los nanomateriales se encuentran presentes en muchos aspectos de la cotidianidad humana. En la escala nanométrica las propiedades de la materia se tornan complejas de analizar y sus efectos difíciles de predecir. Por esto, gran parte de la comunidad científica se ha enfocado en el estudio exhaustivo de sus interacciones con los organismos biológicos, particularmente con el sistema inmunológico, pues es la primera línea de defensa de los seres vivos. Los factores determinantes en la interacción del sistema inmunológico con los nanomateriales son las propiedades fisicoquímicas de estos últimos. A partir de estas interacciones pueden desencadenarse mecanismos de nanoinmunotoxicidad y las reacciones involucradas en los mismos pueden emplearse en técnicas de inmunoterapia para contribuir en la solución de problemas de salud pública. En esta revisión se recopilan algunos de los hallazgos más importantes hasta la fecha acerca de las respuestas inmunológicas provocadas por la exposición a nanomateriales.
Environmental safety of energy storing devices using carbon nanotubes: possible impacts of waste in aquatic and terrestrial environments
Authors: Balsamo Paulo José , Irazusta Silvia Pierre , De Almeida Larissa Solano
Published: June 2024

Electric double layer capacitors (EDLC) are energy storage devices based on the charging and discharging electrode-electrolyte interfaces of high surface area materials such as multi-walled carbon nanotubes (MWCNT) and activated carbon (AC). Despite the broad applicability, the final destination of these components is the environment, mainly water and soil, where they can represent impacts on organisms along different trophic levels. Bioassays with Raphidoceles subcapitata, are widely used to evaluate aquatic totoxicity  and oligochaetes are good terrestrial bioindicators. The study aimed to evaluate aquatic and terrestrial toxicity of MWCNT from EDLC-type capacitors using bioindicators, R. subcapitata and Eisenia andrei. The MWCNT material was synthesized by the floating catalyst-based chemical vapor deposition method (FC-CVD) on stainless steel (AISI 304L). The MWCNT concentrations for the assays were 0.1 1.0, 10 and 100 mg.L–1 for the bioindicator R. subcapitata and the concentrations of 1, 10 and 100 mg.Kg–1 for bioindicator E. andrei. MWCNT inhibited the algal biomass in a concentration dependent manner at concentrations higher than 10 mg.L–1. In the soil the presence of MWCNT, at the concentrations tested did not cause mortality in the earthworm, but resulted in a significant mass reduction in the exposed organisms after 14 days. In the cytology analysis, it was not observed the production of micronuclei, but cytoplasmic vacuolization and nuclear atypia in coelomocytes were frequent. In the comet assay, there was a predominance of nucleoids in the stage 1 classification. Thus, no genotoxic effect was demonstrated in these organisms. The concentrations that showed toxic effects are within the range of environmentally expected concentrations. MWCNT are released from EDLC and may pose an occupational and environmental risk.
Producción fotocatalítica de hidrógeno empleando semiconductores modificados con nanopartículas metálicas
Authors: Ramírez Ortega David , Guerrero Araque Diana Clemencia , Acevedo Peña Próspero , Zanella-Specia Rodolfo
Published: June 2024

Este trabajo de revisión se centra en la producción fotocatalítica de hidrógeno empleando agentes de sacrificio y semiconductores modificados con nanopartículas metálicas. Mientras que el uso de agentes de sacrificio reduce la energía requerida para la producción de hidrógeno y elimina los huecos fotogenerados, la modificación superficial de los semiconductores con nanopartículas metálicas cambia el flujo de los portadores de carga fotoinducidos, disminuyendo la recombinación de los pares electrón-hueco y aumentando la cantidad de sitios activos catalíticos para la reducción. Además, se describe el impacto de las técnicas electroquímicas y fotoelectroquímicas en la caracterización de los fotocatalizadores, la interfase semiconductor/electrolito y la modificación que tiene el nivel de Fermi cuando se ponen en contacto estos componentes. Dichas determinaciones electroquímicas brindan información sobre el diagrama de bandas (posiciones de banda de valencia y/o de conducción), estados energéticos del semiconductor, interacción del fotocatalizador con los co-catalizadores, separación de las especies electrón-hueco, aprovechamiento de la iluminación y resistencia a la transferencia de carga. La relación de la actividad fotocatalítica de los semiconductores y su caracterización electroquímica permite comprender los procesos de transferencia de carga involucrados en dicha reacción.
“El niño” Metinides: el lado humano del fotoperiodismo de nota roja
Authors: Arrieta Yesica
Published: June 2024

Enrique Metinides Tsironides falleció el 10 de mayo pasado, a los 88 años. El reportero gráfico desarrolló una peculiar sensibilidad para convertir un suceso catastrófico en un acto armónico, en sus más de cincuenta años de experiencia en la prensa de nota roja. De hecho, esta habilidad lo internacionalizó y lo llevó a exhibir su trabajo en países como Londres, Alemania, Francia, Estados Unidos, Inglaterra, entre otros.
El impacto del lenguaje en el cuerpo de la mujer
Authors: Bernardino Miranda Diana Jhosebet
Published: June 2024

El documento presenta un análisis del uso del lenguaje y su impacto en la vida de la mujer a partir de su implementación en el contexto social y cultural de nuestro país, en relación con su cuerpo, la influencia del mercado y aspectos relacionados con el patriarcado. Es un artículo biográfico narrativo, Bolívar, et al. 2001 señala que este enfoque permite dar significado, comprender e interpretar hechos y acciones, aspectos cognitivos, afectivos y de acción, a partir de la experiencia y vivencia del sujeto.En este escrito se esboza el uso del lenguaje y el impacto que genera al ser usado para descalificar y estereotipar el cuerpo de la mujer, el cual ha sido blanco de múltiples ofensas, culpas y pecados que se ven traducidos e interpretados a partir del lenguaje. El texto muestra la heterogeneidad del uso del significado del lenguaje, el cual se ve cargado de aspectos simbólicos que tienen un impacto en diferentes ámbitos de nuestra vida, en una sociedad del consumo, feminicidios, búsqueda de identidad, etc., lo cual ha propiciado una desigualdad hacia la mujer. Y esto a su vez también se ve impregnado de ciertos estereotipos, creencias erróneas, imágenes diversas que impactan la concepción de la imagen femenina y el reconocimiento de la mujer con base a su “feminidad”. Surge la necesidad de replantear el uso del lenguaje y el significado que le damos al mismo, es decir, este debe transformarse y deconstruirse, al igual que la imagen del cuerpo de la mujer.
Las tres muertes de Marisela Escobedo
Authors: Coronado Cortés Karen
Published: June 2024

A través de una historia impactante, cruel y desgarradora, permeada de varios pasajes marcados por la injusticia, Carlos Pérez Osorio, director del documental Las Tres Muertes de Marisela Escobedo, expone y describe perfectamente el grado de inseguridad, incompetencia y complicidad por parte de las autoridades de México ante el feminicidio en nuestro país. El documental, nos relata la trágica y lamentable historia de Marisela Escobedo, una madre que nunca dejó de luchar para tratar de lograr justicia para su hija Rubí, quien fue desaparecida y asesinada en Chihuahua, aunque en ese viacrucis, ella correría la misma suerte. El relato, está basado en hechos reales y acompañado por una exhaustiva investigación periodística.
precedentes no sistema brasileiro de justiça multiportas
Authors: Didier Jr. Fredie , Fernandez Leandro
Published: June 2024

O artigo propõe que o respeito aos precedentes seja compreendido como uma norma fundamental do sistema brasileiro de justiça multiportas. Para isso, analisa, em um primeiro momento, a configuração do sistema de justiça no Brasil, estruturado em múltiplos modos de solução de problemas jurídicos, e suas características (auto-organização, abertura, adequação, preferência pela solução consensual e integração). Na sequência, aborda o conteúdo jurídico do art. 926 do Código de Processo Civil brasileiro, dispositivo central no sistema de precedentes. Ao final, examina a abrangência e o significado dos deveres de coerência, integridade e estabilidade no sistema brasileiro de justiça multiportas.
precedentes judiciales en el derecho constitucional colombiano
Authors: Pulido Ortiz Fabio Enrique
Published: June 2024

La regla de precedente es la norma de los sistemas jurídicos que define el funcionamiento normativo de los precedentes judiciales. Los precedentes judiciales son normas generales y abstractas originadas en una decisión judicial. Tomando como ejemplo la forma como se ha configurado la regla de precedente en el derecho constitucional colombiano, el objetivo de este artículo es analizar diferentes tipos de precedentes judiciales y, en este contexto, precisar la noción de ratio decidendi. El trabajo distingue entre precedente judicial en sentido amplio que refiere a las normas generales y abstractas de origen judicial que, en virtud de la regla de precedente, son obligatorias o vinculantes, y el precedente judicial en estricto sentido que designa a la ratio decidendi de las decisiones judiciales. Luego se analiza el precedente en estricto sentido explicando los modelos de construcción de la ratio decidendi, su configuración como norma jurídica y los elementos para su identificación.
construcción de una cultura jurídica para el precedente: desafíos y soluciones
Authors: Ratti Mendaña Florencia
Published: June 2024

El trabajo describe ciertas prácticas deficientes en la aplicación del precedente —con especial énfasis en Argentina— y propone mecanismos de mejora. Para ello, parte de las siguientes premisas: (1) el precedente puede asumir diversas particularidades de funcionamiento en cada sistema jurídico (incluso su aplicación y su valor pueden variar dentro de un mismo sistema y hasta dentro de un mismo tribunal), pero (2) existen prácticas de aplicación actual del precedente que contradicen los fines específicos a los que se orienta el respeto por las decisiones pasadas (seguridad jurídica, igualdad, economía procesal). Con respecto a estas prácticas, se postula que la regulación normativa del precedente es insuficiente para reencauzar su uso, y que es necesaria la concomitante modificación de ciertas actitudes forenses, así como la adquisición de habilidades específicas. Entre las soluciones necesarias, se destaca la capacitación de los diversos operadores jurídicos como propuesta transversal.
¿Efecto relativo de las sentencias o jurisprudencia como fuente de derecho? Una propuesta de conciliación para una tensión irresoluta
Authors: Agüero-SanJuan Sebastián
Published: June 2024

La comunidad jurídica chilena ampliamente comparte dos ideas que están en tensión entre sí: por un lado, a partir del Código Civil de 1857, especialmente, con base en su artículo tercero se reconoce un efecto relativo de las sentencias, es decir, la fuerza obligatoria de las decisiones de los tribunales de justicia es sólo respecto de las causas en que se pronuncien, por el otro, a partir de la práctica jurídica, se reconoce a la jurisprudencia como una fuente del derecho, es decir, se acepta que las decisiones de los principales tribunales de justicia tienen fuerza vinculante más allá de los intervinientes en los juicios. Por ello, frente a esta tensión irresoluta, el objetivo de este trabajo es doble. Primero, a partir de la revisión de la doctrina y la jurisprudencia chilena, poner de manifiesto la tensión y precisar las razones de su surgimiento. Y, segundo, formular una propuesta que busque conciliar ambas ideas mediante: precisar el objeto de la controversia, acotar los alcances de la jurisprudencia y sugerir qué tipo de normatividad (carácter vinculante) tendría las decisiones de los principales tribunales de justicia.
detección de la corrupción en México y el Sistema Nacional Anticorrupción
Authors: Gutiérrez Salazar Miguel Ángel
Published: June 2024

El objetivo del presente ensayo consiste en analizar las herramientas con que cuenta el Estado mexicano para identificar y combatir los actos de corrupción; en ese contexto, se estudia el diseño normativo, institucional y de políticas públicas que ha adoptado nuestro país para enfrentar dicho fenómeno. Asimismo, se exponen los antecedentes del combate a la corrupción, se señalan las principales adecuaciones normativas y los cambios estructurales que han tenido lugar para construir el régimen de responsabilidades vigente. Además, se explica la implementación y funcionamiento del Sistema Nacional Anticorrupción, para coordinar los esfuerzos de prevención, detección y sanción de estos actos. Finalmente, se destacan los retos y perspectivas, al tiempo que se sugieren estrategias de acción en la materia.
debate constitucional sobre el derecho al aborto en Estados Unidos
Authors: Gómez Peralta Héctor
Published: June 2024

El artículo muestra el debate constitucional sobre el derecho al aborto entre las diferentes escuelas jurídicas dominantes en la Suprema Corte de los Estados Unidos de América. Se sostiene que el debate en el seno de la Suprema Corte de ese país, además de ser una lucha entre liberales y conservadores, es también entre dos filosofías jurídicas sobre cuál debe de ser el papel político del Poder Judicial dentro de una sociedad que se considera a sí misma democrática: el activismo judicial vs. la restricción judicial —esta última integrada por el originalismo y el textualismo—.
secreto profesional de los abogados: un caso en la jurisprudencia mexicana
Authors: Vázquez Cardozo Oscar
Published: June 2024

El presente trabajo analiza dos sentencias que tienen por objeto estudiar las relaciones cliente-abogado y las obligaciones que tiene el último para guardar el secreto profesional en el desempeño de su gestión y privacidad de las comunicaciones entre ambos.
Transparencia y acceso a la información en el Acuerdo de Escazú: alcances y desafíos para la justicia ambiental en México
Authors: Hernández Barrera Yeshu
Published: June 2024

El Acuerdo de Escazú, adoptado por México en 2021, es un tratado que sirve para poner en práctica los derechos de acceso a la información, participación pública y acceso a la justicia en asuntos ambientales o derechos procesales del medio ambiente. Este trabajo aborda el análisis de este tratado a partir de las decisiones de los tribunales nacionales e internacionales para hacer efectivo el derecho de acceso a la información en asuntos ambientales, aunque también desde la visión práctica de la defensa ambiental. Además, se utilizan ejemplos concretos de solicitudes de transparencia y recursos de revisión presentados ante los órganos garantes. El fin de este análisis es clarificar los alcances del derecho al acceso a la información y los principales deberes correlativos de transparencia ambiental, con base en el Acuerdo de Escazú; además de confrontarlo con la práctica. Asimismo, se demuestra que el derecho humano en mención es un derecho instrumental para que las personas tengan conocimiento previo y comprendan los riesgos y daños ambientales de las actividades y omisiones estatales. El hilo conductor de esta investigación es demostrar — mediante ejemplos concretos— los alcances de la transparencia ambiental, para que las personas afectadas por proyectos o actividades que dañen al medio ambiente puedan acceder a la información y preparar acciones jurídicas para defenderse. Asimismo, se expone la importancia de la existencia de órganos de transparencia y de eliminación de prácticas contrarias al Acuerdo de Escazú que pretenden ocultar la información y los principios ambientales que consagra ese tratado.
Social Empowerment Of Pastoral Literacy At STK St. Yakobus Merauke: ODOA Program (One Day One Article) As An Innovative Strategy
Authors: Makasau Rosmayasinta , Wahyono Eko , A Cyril Njume
Published: June 2024

This research was triggered by the low of literacy culture and skills of students in pastoral care which impact on the quality of their services to the people. The objectives of this study are: 1) to explain the current condition of pastoral literacy of students at STK St. Yakobus Merauke and 2) present guidelines/ procedures for designing ODOA program implementation activities for pastoral literacy activities. This research uses qualitative method – descriptive approach, using Miles & Huberman (1984) theories in data analysis, namely: data reduction, data presentation and data verification. In-depth interviews were conducted with 10 students of the seventh semester, 4 lecturers who are competent in the pastoral field, and 1 head of UPT Library to obtain the necessary data according to research objectives. The results of the research showed that the condition of the pastoral literacy phase of students is currently in the 3rd position of 6 literacy phases (early literacy, basic literacy, library literacy, media literacy, technological literacy, and visual literacy) literacy initiated by Clay and Fegurson (2001). The 3rd stage or stage in question is the library literacy stage. The pastoral literacy program through the continuous and controlled implementation of ODOA (One Day One Article) is a means to improve students' literacy culture and skills in teaching. The conclusion of the research is by the implementation of ODOA program shows the improvement of students’ pastoral literacy habits and pastoral skills. The novelty of this research is that the presentation of the latest information regarding the position of student’s pastoral literacy stages in South Papua.
Exploration of Co-Creation Strategy: On the “Collaboration for Innovation” Program in the Digital Era
Authors: Parwati Ida Ayu , Martini Ida Ayu Oka
Published: June 2024

This research seeks to understand the exploration of co-creation strategies in the collaborative strategy program for innovation in the digital era at Bank OCBC through a qualitative descriptive approach. Study data was collected through documentation, observation, and conducting in-depth interviews directly with 4 informants. The data was then analyzed using a triangulation approach, both sources and techniques, which were guided by the theory of Miles et al. The findings indicate that marketing strategies in the current digital era see collaboration between companies and customers through co-creation. At Bank OCBC, it is implemented well by paying attention to dialogue, access, risk assessment and transparency (DART) in the current era of digital disruption, the co-creation process used by Bank OCBC can be shortened by using platforms such as websites and social media so that it takes advantage of this platform by exchanging ideas with customers to see what they want about current banking products or asking for reviews regarding products that OCBC Bank already has and customer satisfaction in using the products they have so that it has an impact on sustainability. This study is able to make a positive contribution to marketing literature in product marketing and practically for banks in maintaining the business sustainability of financial institutions in Indonesia.