bluuebunny/crossref_metadata_2025 huggingface dataset:
A predictive model for the critical shoulder angle based on a three-dimensional analysis of scapular morphology
Authors: Smith Geoffrey , Geelan-Small Peter , Sawang Michael
Published: June 2022

BackgroundThe purpose of this study was to define the features of scapular morphology that are associated with changes in the critical shoulder angle (CSA) by developing the best predictive model for the CSA based on multiple potential explanatory variables, using a completely 3D assessment.Methods3D meshes were created using CT DICOMs. The analysis included 17 potential angular, weighted linear and area measurements. The correlation of the explanatory variables with the CSA was investigated with the Pearson’s correlation coefficient. Using multivariable linear regression, the approach for predictive model-building was leave-one-out cross-validation and best subset selection.Results53 meshes were analysed. Glenoid inclination (GI) and coronal plane angulation of the acromion (CPAA) [Pearson’s r: 0.535; -0.502] correlated best with CSA. The best model (adjusted R-squared value 0.67) for CSA prediction contained 10 explanatory variables including glenoid, scapular spine and acromial factors. CPAA and GI were the most important based on their distribution, estimate of coefficients and loss in predictive power if removed.ConclusionsThe relationship between scapular morphology and CSA is more complex than the concept of it being dictated solely by GI and acromial horizontal offset and includes glenoid, scapular spine and acromial factors of which CPAA and GI are most important.Level of evidence: Level 4 retrospective observational cohort study with no comparison group.
Microglial NLRP3 inflammasome activation mediates diabetes-induced depression-like behavior of mice via triggering neuroinflammation
Authors: Su Wen-Jun , Li Jia-Mei , Zhang Ting , Cao Zhi-Yong , Hu Ting , Zhong Shi-Yang , Hong Gong , Jiang Chun-Lei
Published: June 2022

Background Abundant evidence suggests that people with diabetes have a higher prevalence and risk of depression compared to the general population. However, the pathogenesis of diabetes-related depression remains unclear. As neuroinflammation is associated with diabetic complications and the pathophysiology of depression, this study aimed to elucidate the neuroimmunological mechanisms of diabetes-related depression.Methods Male C57BL/6 mice were injected with streptozotocin (200 mg/kg, i.p.) to establish a diabetes model. After screening for hyperglycemia, diabetic mice were treated with the NLRP3 inhibitor MCC950 (20 mg/kg, i.p.) for 7 days. Then, the mice were assessed for metabolic indicators and depression-like behaviors, and their levels of central and peripheral inflammation were measured. To explore the mechanism of high glucose-induced microglial NLRP3 activation, we performed in vitro studies using BV2 mouse microglia. Furthermore, we focused on upstream signal I (TLR4/MyD88/NF-κB) and signal II (ROS/PKR/P2X7R/TXNIP) that may be involved in microglial inflammasome activation.Results STZ-induced diabetic mice exhibited microglial NLRP3 inflammasome activation and developed depression-like behaviors. In vitro high-glucose (50 mM) environment promoted phosphorylation of the NF-κB p65 subunit through a TLR4/MyD88-independent way, thereby sensitizing the microglial NLRP3 inflammasome. Subsequently, high glucose activated the NLRP3 inflammasome via upregulating P2X7R, as well as enhancing intracellular ROS accumulation, promoting PKR phosphorylation and TXNIP expression, thereby facilitating IL-1β production and secretion. The NLRP3 inhibitor MCC950 significantly restored hyperglycemia-induced depression and activation of the microglial NLRP3 inflammasome, and reversed the elevation of IL-1β levels in hippocampus and serum. Conclusion Microglial NLRP3 activation mediates the development of the depression-like behaviors evoked by STZ-induced diabetes in mice. Targeting the microglial NLRP3 inflammasome is a feasible strategy for the treatment of diabetes-related depression. This study provides new evidence for a comprehensive understanding of psychoneuroimmunology.
Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency
Authors: Walz Juliane , Heitmann Jonas , Tandler Claudia , Marconato Maddalena , Habibzade Timursah , Rittig Susanne , Tegeler Christian , Nelde Annika , Maringer Yacine , Jäger Simon , Denk Monika , Richter Marion , Oezbek Melek , Wiesmüller Karl-Heinz , Bauer Jens , Rieth Jonas , Wacker Marcel , Schroeder Sarah , Gravel Naomi Hoenisch , Märklin Melanie , Henrich Annika , Klimovich Boris , Clar Kim , Lutz Martina , Holzmayer Samuel , Hoerber Sebastian , Peter Andreas , Meisner Christoph , Fischer Imma , Löffler Markus , Peuker Caroline , Habringer Stefan , Goetze Thorsten , Jäger Elke , Rammensee Hans-Georg , Salih Helmut
Published: June 2022

T-cell immunity is central for the control of COVID-19, in particular in patients incapable to mount a humoral immune response. We previously reported on the favorable safety profile and efficacy in terms of induction of SARS-CoV-2-specific T-cell responses by CoVac-1, a peptide-based T-cell activator, composed of SARS-CoV-2 T-cell epitopes derived from various viral proteins, combined with the toll-like receptor 1/2 agonist XS151. We conducted a Phase I/II open-label trial recruiting 54 patients with congenital or acquired B-cell deficiency who received one single subcutaneous dose of CoVac-1. Immunogenicity until day 28 in terms of CoVac-1-induced T-cell responses was the primary endpoint; safety until day 56 was assessed as secondary endpoint. Neither serious nor grade 4 CoVac-1-related adverse events were observed. The expected local granuloma formation was observed in 94% of study subjects, whereas systemic reactogenicity was mostly mild or absent. SARS-CoV-2-specific Tcell responses were induced in 86% of the patients and directed to multiple CoVac-1 peptides, not affected by any current Omicron variants and mediated by multifunctional T-helper 1 CD4+ T cells. CoVac-1-induced T-cell responses exceeded spike-specific T-cell responses after vaccination with mRNA vaccines in B-cell deficient patients and also that of immunocompetent COVID-19 convalescents with and without seroconversion. CoVac-1 induces broad and potent T-cell responses in patients with Bcell/antibody deficiency independently of current variants of concern, with a favorable safety profile. Our data warrant advancement to a pivotal Phase II/III safety and efficacy evaluation.
Machine Learning Decomposition of the Depression Connectome Provides Potential Markers and Targets for Transcranial Magnetic Stimulation
Authors: Taylor Hugh , Nicholas Peter , Tanglay Onur , Young Isabella M. , Doyen Stephane , Sughrue Michael E. , Fitzgerald Paul B.
Published: June 2022

Despite efforts to improve targeting of the dorsolateral prefrontal cortex (DLPFC) in repetitive transcranial magnetic stimulation (rTMS) for Major Depressive Disorder (MDD), the heterogeneity in clinical response remains unexplained. We compared patterns of functional connectivity from the DLPFC in patients with MDD between responders and non-responders to rTMS. Baseline anatomical T1 magnetic resonance imaging (MRI), resting-state functional MRI, and diffusion weighted imaging scans were obtained from 37 participants. A machine learning method was utilized to identify brain regions associated with each item of the Beck’s Depression Inventory II (BDI-II), and for 26 participants who underwent rTMS over the left Brodmann area 46, identify brain regions differentiating responders and non-responders. Nine parcels of the Human Connectome Project Multimodal Parcellation Atlas matched to at least three items of the BDI-II as predictors of response to rTMS, with many in the temporal, parietal and cingulate cortices. Pre-treatment mapping for 17 items of the BDI-II demonstrated significant variability in symptom to parcel mapping. When parcels associated with symptom presence and symptom resolution were compared, 15 were uniquely associated with resolution, and 12 with both symptom presence and resolution. Machine learning approaches show promise for the development of pathoanatomical diagnosis and treatment algorithms for MDD.
Analysis of the Current Situation and Influencing Factors of Dietary-Culture-Related Nutrition Knowledge, Attitudes, and Practices of Chinese Netizens: A cross-sectional Study
Authors: Zhang Qian , Yang Yuan , Xiang Lian , Du Tingwan , Ma Lilai , Zhou Yanqiu , Ma Ling
Published: June 2022

Background
Dietary culture affects people's cognition and attitudes toward nutrition, and it even dictates people's dietary behavior. This study aimed to assess the dietary-culture-related KAP of Chinese netizens during the corona virus disease 2019(COVID-19) pandemic.
Methods
A cross-sectional survey was conducted using an online KAP questionnaire in China. Volunteers were recruited at Southwest Medical University and were first trained to unify standards of distributing questionnaires. Participants were recruited by convenient- and snowball-sampling methods. Multiple regression analysis was used to analyze the influential factors.
Results
After 50 days of investigation, 3514 participants (40.6% men) were valid. The mean score of netizens’ nutrition knowledge was 3.9 ± 2.2 and the mean awareness rate was 31.7%. Women participants in the age group of 30–39 with higher education level had higher nutrition knowledge qualification rate. During the COVID-19 pandemic, the positive rate of attitude toward dietary-culture-related nutrition was 93.7%, and women netizens who had higher level of education and immigrated from other places had better attitudes. Moreover, the positive rate of dietary habits was 90.7%, and older women netizens had better dietary behavior.
Conclusions
Netizens’ knowledge of nutrition was poor, but their dietary habits and attitudes toward dietary-culture-related nutrition were generally positive, which was also a great progress for Chinese people.
Close kin influence COVID-19 precautionary behaviors and vaccine acceptance of older individuals
Authors: Arpino Bruno , Bordone Valeria , Gessa Giorgio Di
Published: June 2022

The family plays a central role in shaping health behaviors of its members through social control and support mechanisms. We investigate whether and to what extent close kin (i.e., partner and children) have mattered for older people in taking on precautionary behaviors (e.g., physical distancing) and vaccination during the COVID-19 pandemic in Europe. Drawing on data from the Survey of Health, Ageing and Retirement in Europe (SHARE), we combine its Corona Surveys (June-August 2020 and June-August 2021) with pre-COVID information (October 2019-March2020). We find that having close kin (especially a partner) is associated with a higher probability of both adopting precautionary behaviors and accepting a COVID-19 vaccine. Results are robust to controlling for other potential drivers of precautionary behaviors and vaccine acceptance, as well as to accounting for co-residence with kin. Our findings suggest that policy makers and practitioners may differently address kinless individuals when promoting public policy measures.
Ferroptosis-related lncRNA signature robustly predicts the prognosis and immunotherapy efficiency of clear cell renal cell carcinoma
Authors: Ju Lincheng , Shi Yaxing , Liu Gang
Published: June 2022

Background:Ferroptosis is a new type of iron- and reactive oxygen species-dependent cell death, which is observed in a variety of disease conditions and plays an important role in cancer. However, studies on ferroptosis-related long noncoding RNAs (FerLncRNAs) in clear cell renal cell carcinoma (ccRCC) are limited. The purpose of this study was to investigate the potential prognostic value of FerLncRNAs and their relationship with the immune microenvironment and immunotherapy response of ccRCC.Methods: RNA sequencing data of 526 patients with ccRCC were downloaded from The Cancer Genome Atlas (TCGA) database. The patients with ccRCC in TCGA were randomly divided (1:1) into a training and testing cohort. ICGC and GEO databases were used for validation. Screening for FerLncRNAs was performed using Pearson’s correlation analysis with the reported ferroptosis-related genes. A FerLncRNA signature was constructed using univariate, LASSO, and multivariate Cox regression analyses in the training cohort. Internal and external datasets were performed to verify the FRlncRNA signature. Four major FRlncRNAs were verified through in vitro experiment.Results: A FerLncRNA signature (LINC00894, DUXAP8, LINC01426, PVT1, PELATON, LINC02609, and MYG1-AS1) was established. Patients in the high-risk group had a worse prognosis than those in the low-risk group. Analysis of the area under the time-dependent ROC curve (AUC) confirmed the predictive accuracy of the signature was better than the traditional evaluation factors; the AUC value for 5-year survival reached 0.772 in the total cohort. Multivariate Cox regression analysis showed that the risk score was an independent prognostic indicator. A nomogram was established based on the risk signature and clinical features to accurately predict the survival of patients with ccRCC. Four major FRlncRNAs (LINC00894, LINC01426, PVT1, and DUXAP8) were verified with the prognosis of ccRCC in the GEPIA and K-M Plotter databases, their expressions were validated by realtime PCR. Gene set enrichment analysis revealed the immune and tumor-related pathways in the individuals from the two risk groups. The immune cell infiltration landscapes and expression levels of immune checkpoints showed significantly different between the low- and high-risk groups. Finally, TIDE and ImmuCellAI analyses showed that patients in the low-risk group were more inclined to respond to immunotherapy than patients in the high-risk group. In addition, drug sensitivity analysis indicated that our risk signature had potential predictive value for chemotherapeutics and targeted therapy. Conclusions: Our study established a novel FerLncRNA signature with robust predictive ability for survival and efficiency in predicting the response to immunotherapy, chemotherapy and targeted therapy in ccRCC patients. Its component FerLncRNAs may serve as therapeutic targets for ccRCC.
Research on Factors Influencing the Training of Artificial Intelligence Applied Talents Based on DEMATEL-TAISM
Authors: Bian Yi-jie , Xie Lu , Li Jing-qi
Published: June 2022

The identification of key influencing factors in the training of applied talents in artificial intelligence includes two stages, namely, the establishment of factor index system and the identification of key influencing factors. Firstly, referring to a large number of literatures on the influencing factors of talent training and the sustainability evaluation index framework at home and abroad, and in combination with the characteristics of the development of China's artificial intelligence industry, this paper summarizes the influencing factors from the multi-dimensional training path of government departments, universities, enterprises and scientific research institutes. According to the training purpose of artificial intelligence application-oriented talent training, this paper constructs the influencing factor index system of artificial intelligence applied talents training. Then, the DEMATEL method is used to establish multiple correlation matrices according to the direct influence correlation between the factors, and the degree of influence, the degree of being influenced, the centrality degree, and the reason degree are calculated; Using the improved AISM method and based on the idea of game confrontation, a set of confrontation level topological maps with comprehensive influence values reflecting the interaction of factors are obtained from the two opposite extraction rules of result priority and cause priority, respectively. Finally, the relevant suggestions are put forward in order to provide reference for promoting the training of applied talents in China's artificial intelligence industry.
Association between tea consumption and quality of life in men with esophageal squamous carcinoma based on TTD model
Authors: Zhang Juwei , Liu Shuang , Song Jianyu , Zhou Jinsong , Zeng Qiaoyan , Ling Zheng , Yu Kaili , Rao Wenqing , Zhang Suhong , Lin Zhifeng , Qiu Minglian , Chen Yuanmei , Hu Zhijian
Published: June 2022

PurposeTo explore the association between postoperative tea drinking and quality of life in male patients with esophageal squamous cell carcinoma (ESCC).MethodsThe data was collected using the esophageal cancer quality of life questionnaire. The time to deterioration (TTD) model was used to measure ESCC patients' quality of life. The association between postoperative tea drinking and postoperative quality of life in male ESCC patients was investigated using the Cox proportional hazard model.ResultsPostoperative tea-drinking patients experienced delayed TTD in multiple domains, including general health, physical, role, emotional, and cognitive function, fatigue, nausea and vomiting, dyspnea, loss of appetite, constipation, diarrhea, eating problems, difficulty swallowing, choking while swallowing saliva, dry mouth, taste difficulties, coughing, and speech problems. The multivariate Cox regression analysis showed that drinking tea after surgery improved quality of life, including physical (HR=0.719, 95% CI: 0.557-0.929) and role function (HR=0.737, 95% CI: 0.555- 0.978), eating problems (HR=0.724, 95% CI: 0.542-0.967), odynophagia (HR=0.683, 95% CI: 0.493-0.946), trouble swallowing saliva (HR=0.624, 95% CI: 0.444-0.877), coughing (HR=0.628, 95% CI: 0.443- 0.890) and speech problems (HR=0.630, 95% CI: 0.441-0.902). Furthermore, the improvement was more significant in patients who drank tea before surgery and continued to drink tea after surgery.ConclusionsPostoperative tea drinking improved and delayed the worsening of multiple functions and symptoms associated with ESCC on the EORTC QLQ-C30 and EORTC QLQ-OES18 scales in male ESCC patients. Furthermore, the improvement was more significant in patients who drank tea before surgery and continued to drink tea after surgery.
Genetic polymorphisms of rs12437118 in ESRRB locus associated with tuberculosis susceptibility in a Chinese Han population
Authors: Wang# Wei , Zhao# Lingjuan , Sun Yong , Ren Weicong , Zhang Xuxia , Li Chuanyou , Gao Mengqiu
Published: June 2022

ESRRB (Estrogen Related Receptor Beta) plays a crucial role in stem cells self-renewal, naïve pluripotency, and early development of the embryo via participating in regulation of chromatin remodeling. The objective was to investigate whether rs12437118 in ESRRB locus was associated with tuberculosis susceptibility in a Chinese Han cohort. A total of 607 TB patients and 660 healthcare workers were enrolled for this study. ESRRB rs12437118 polymorphisms genotyping was performed by competitive allele-specific PCR (KASP) assay. ESRRB plasma expression level was detected by enzyme linked immunosorbent assay (ELISA). Logistic regression was used to calculated odds ratios (ORs) and 95% confidence intervals (CIs). Genotype GA showed a decreased risk of TB (P = 0.014, OR = 0.745, 95%CI: 0.59–0.94). No association with TB risk was found for other genotypes and any genetic model. ESRRB expression lower in TB patients than in healthy controls, but no association was found between ESRRB expression level in plasma and different genotypes of rs12437118. Our results demonstrated that genotype GA of rs12437118 decreased risk of TB in a Han cohort in North of China.
Prognostic Value of Simultaneous Analysis with Myocardial Flow Reserve and Right Ventricular Strain by Hybrid 13N-ammonia Positron Emission Tomography/Magnetic Resonance Imaging in Coronary Artery Disease
Authors: Endo Keiichiro , Kiko Takatoyo , Yamakuni Ryo , Misaka Tomofumi , Yamaki Takayoshi , Nakazato Kazuhiko , Fukushima Kenji , Takeishi Yasuchika
Published: June 2022

Myocardial flow reserve (MFR) derived from 13N-ammonia positron emission tomography (PET) is used to predict adverse cardiac events in the patients with coronary artery disease (CAD). Right ventricular (RV) strain measured by magnetic resonance imaging (MRI) is used to evaluate RV function and predict cardiac events. This study aimed to evaluate the prognostic value of MFR and RV strain measured by hybrid 13N-ammonia PET/MRI in patients with CAD. Sixty-one patients who underwent 13N-ammonia PET/MRI were enrolled. The end points were defined as a composite of all-cause death, myocardial infarction, sustained ventricular arrhythmia, hospitalization due to decompensated heart failure, and revascularization. At a follow-up of 2.8 ± 1.9 years, 21 events occurred. Kaplan–Meier analysis showed that the event-free rate was significantly lower in the group with MFR < 1.80 than that with MFR ≥ 1.80 (P < 0.001). Additionally, the event-free rate was significantly lower in the group with RVGLS > −18.22% than that with RVGLS ≤ −18.22% (P = 0.025). After dividing the patients into four groups by the median MFR and the median RVGLS, the event-free rate was lowest in the combined group of MFR < 1.80 and RVGLS > -18.22% than any other groups (P < 0.001). In the Cox proportional hazard analysis, MFR and RVGLS were independent predictors of cardiac adverse events in the patients with CAD. The simultaneous assessment of MFR and RV strain by 13N-ammonia PET/MRI revealed the feasibility of precise risk stratification for cardiac events in patients with CAD.
Expression and potential immune involvement of cuproptosis in kidney renal clear cell carcinoma
Authors: Liu Hengrui
Published: June 2022

Cuproptosis is a newly identified programmed cell death pathway mediated by intracellular free copper. Three anti-cuproptosis genes (MTF1, GLS, and CDKN2A) and seven pro-cuproptosis genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, and PDHB) genes with an anti-cuproptosis copper exporter ATP7B and a pro-cuproptosis copper importer SLC31A1 were studied in this study for a better insight into the role of cuproptosis in cancers. Our preliminary screening analysis based on these 12 cuproptosis genes across more than 9000 samples of 33 types of solid tumors identified kidney renal clear cell carcinoma (KIRC) as a cancer type most likely to be affected by cuproptosis. This study analyzed the multi-omic data to explore the cancer-noncancer expression pattern and potential immune involvement of the cuproptosis pathway in KIRC. We clustered the TCGA KIRC samples based on the cuproptosis gene set to study the role of cuproptosis in the KIRC immune and found the potential value of cuproptosis signature for immunotherapy prognosis. We concluded that cuproptosis might affect KIRC and had potential value in immune therapy. We hope this study can contribute to the application of cuproptosis in the clinical therapy of KIRC.
Prevalence of emergence delirium and associated factors among old-age patients who underwent elective surgery in the Teaching Hospitals of Ethiopia, Ethiopia, 2021. A multicenter prospective observational study
Authors: Tageza Tajera
Published: June 2022

Background
Emergence Delirium is a common and serious post-operative complication in surgical patients, especially in the old-age. It occurs at any time in the perioperative period, during or immediately following emergence from general anesthesia. Unfortunately, it is highly associated with post-operative complications such as decrease in functional capacity, prolonged hospital stay, an increase in health care costs and morbidity and mortality. The goal of this study was to determine the prevalence of emergence delirium and associated factors among old-age patients who underwent elective surgery in the Teaching Hospitals of Ethiopia at post anesthesia care unit, 2021.
Methods
A multi-center prospective observational study was conducted at the post-anesthetic care unit of four teaching hospitals in Ethiopia. Old-age surgical patients admitted to Post-anesthesia Care Unit who underwent elective surgery in the four Teaching Hospitals of Ethiopia were selected by using simple random sampling. Pretested structured questionnaire was used to collect data. Data were entered in to Epidata (version 4.6) and exported to the SPSS (version 25.0). Binary logistic regression was used to identify factors independently associated with emergence delirium.
Results
Out of 384 old-age patients included in the study with 100% response rate, the Prevalence of emergence delirium was 27.6%. Preoperative low hemoglobin levels (AOR: 2.0, 95%CI; 1.77–3.46), opioids (AOR: 8.0, 95%CI; 3.22–27.8) and anti-cholinergic premedications (AOR: 8.5, 95%CI; 6.85–17.35), and post-operative pain (AOR: 3.10, 95CI; 2.07–9.84) at PACU were independently associated with emergence delirium.
Conclusion
The Prevalence of emergence delirium was high. Old-age patients who were premedicated with anti-cholinergic and opioids, those patients who had low pre-operative hemoglobin and post-operative pain were independently associated with emergence delirium. Adequate pre-operative optimization and post-operative analgesia may reduce the Prevalence of emergence delirium.
Research on management theory: A development review and bibliometric analysis
Authors: Skačkauskienė Ilona
Published: June 2022

While the literature on management theory has been growing in recent years, there are no publications regarding the evolution and mapping of this scientific field. This study dwells on the issues related to management theories in the context of today’s research by identifying the most important lines of research, researchers, and the concentration of research. To explore the trends in the development of management theory, this study used bibliometric analysis. The search in the Web of Science database provided 5,825 documents (including articles, books, reviews, etc.). Methods of trend analysis, clusterization, and comparative analysis were used. The results show that a new direction of responsible management research is being formed – the organization’s operations and objectives must be balanced, and their implementation must be responsible. This study enriches management literature by providing new ideas related to future research tendencies. Moreover, it fleshes out the direction for developing management theory and outlines the most-cited works and authors, the research concentration in different countries, and leading journals. For scholars and practitioners, such structured data are an important source of relevant information in published papers and allows for the definition of research guidelines.
Degree Completion Nursing Students’ Perceptions of Their Readiness to Learn Online
Authors: Sebuliba Faith Rosemary K.
Published: June 2022

Raising the professional knowledge and skill of nurses through acquiring a baccalaureate degree has shown evidence of an increase in the provision of quality care, a reduction in mortality rates in hospitals, and increase in patient safety. Institutions of higher education have adopted online learning for degree-completion nursing programs in Uganda to advance more nurses to the baccalaureate level. This paper presents the findings from the qualitative phase of a mixed-method study that explored factors that contribute to students’ self-efficacy to learn online. In the quantitative phase of the study, 226 nursing students were surveyed about their personal attributes, technical competences, and institutional supports that contributed to their self-efficacy to learn online. The surveys revealed that a majority of the students (58%) reported moderate to high levels of readiness to learn online. The qualitative phase was designed to elicit the students’ perception of those factors that influenced self-efficacy to learn online. It was also conducted during the COVID pandemic and captured the students’ perceptions during the online study. Two focus group discussions were held with a representative sample from the students (n-14) who participated in the survey portion of the study. The findings provided an understanding of students’ perceptions of online learning readiness, the challenges they faced, and insights into how educators, employers, and families can support students’ online learning. The findings can be generalized to students such as those in degree-completion programs, who are employed, and who study from rural or low resource areas globally.
The role of family counseling in handling autistic children during at-home learning periods
Authors: Mujahid Imam , Abdullah Irwan , Minsih Minsih , Muhamad Siti Norlina
Published: June 2022

The creation of good relations between family members during the COVID-19 pandemic is considered important to accommodate the learning needs of autistic children as during the pandemic, they are not able to learn optimally. This study aims to establish the role of family counseling in handling autistic children during at-home learning. The research uses a qualitative case study design. The informants were parents and core families of autistic children, and data collection involved interviews, observations, and documentation. The data analysis techniques employed were inductive analysis through reduction, data description, data coding, interpretation, and conclusions. The results show that the involvement of family members took place on a scheduled basis, relations between them improve, and making independent. The passion for building self-potential by developing a sense of respect for family members who help with autistic children's activities when learning from home. Family counseling through the involvement of family members can have a positive effect on the behavioral development of autistic children and a beneficial impact on other family members. The implication is that family counseling can be applied to help the social-emotional development of autistic children.
Resilience in health workers: The role of social support and calling
Authors: Koamesah Grace Tesabela , Virlia Stefani , Musa Muwaga
Published: June 2022

Health workers are professionals with high exposure to various types of stress; therefore, they need resilience to survive in their profession. This research aims to test the effect of social support and calling on resilience in health workers.  It is a quantitative-correlational study conducted cross-sectionally. The instruments used were the Connor-Davidson Resilience Scale, Multidimensional Support Scale, and Calling Scale. Snowball sampling was used to identify participants, consisting of 113 health workers in East Nusa Tenggara province, Indonesia. The data were analyzed with multiple linear regression techniques. Significant effects of social support and calling were found on resilience (p .01, F = 34.224), with calling shown to have more significant impact (p .01, F = 60.685) and 35.3% effective contribution. Amongst the types of social support, coworkers make the most significant contribution of 11.8% (p .01, F = 14.816), followed by family members at 9.6% (p .01, F = 11.752). On the other hand, social support from supervisors does not affect resilience (p .05, F = 0.904). Health workers should seek the social support they need proactively, and prospective health workers should consider their calling when choosing a career.
Clinical Benefit of Vaccinating Male Against HPV-related Disease
Authors: Lee Sei Young
Published: June 2022

HHPV (Human Papillomavirus) is a DNA virus that can cause benign lesions, genitourinary cancer, and oropharyngeal cancer by penetrating the mucous membrane and skin. It is widely known to be transmitted mainly through sexual contact. As with many viral infections, vaccines have been developed to prevent infection with HPV. Currently, in many countries, HPV vaccines are mainly used for national immunization for women to prevent diseases that traditionally occur frequently in women, especially cervical cancer. However, since the vaccination rate is relatively low, many countries are struggling with ways to increase the vaccination rate. Meanwhile, the incidence of oropharyngeal cancer caused by HPV in men has been increasing recently. In the United States, the annual number of oropharyngeal cancers in men already exceeds the number of cervical cancers in women, so HPV infection in men has emerged as a major problem. Accordingly, interest in HPV vaccination in men has also increased, and studies on the effectiveness and necessity of vaccination of both women and men compared to women alone are being actively conducted. In this paper, the evidence of HPV vaccination for men will be reviewed through previous studies, and its validity and cost-effectiveness will be analyzed to bolster the clinical usefulness of HPV vaccination for men.
A Case of the Soft Palate Reconstruction Using the Bilateral Palatal Mucomuscular Flap and Pharyngeal Flap after Wide Resection
Authors: Gu Ga Young , Lee Hye Ran , Jang Jeon Yeob
Published: June 2022

The soft palate of carcinoma limited to the uvular region is infrequent among oropharyngeal cancers. The oropharynx regulates swallowing and speech through dynamic motions. Failure to reconstruct after surgical resection of the oropharynx structure can lead to permanent velopharyngeal insufficiency. Therefore, suitable reconstruction is important in establishing proper functional outcomes while maintaining oncological safety.
We present a case of a 66-year-old male who was diagnosed with oropharynx cancer limited in the uvula accompanied by lymph node metastasis. After surgical resection, reconstruction was performed with the united arrangement of bilateral palatal mucomuscular flap and superiorly based posterior pharyngeal flap. There was no aspiration or reflux after feeding and epithelialization completely occurred after 1 month postoperatively. We report a successful case that the reconstruction with the local flap described above could preserve proper oropharyngeal function after primary surgery in small-sized oropharyngeal cancer.
Intrathyroid Thyroglossal Duct Cyst Extending into the Mediastinum: A Case Report and Review of Literature
Authors: Lee Chan Mi , Hong Yong Tae
Published: June 2022

Thyroglossal duct cyst (TGDC) is the most common congenital cyst in the neck and usually presents in children. It is most commonly located at the infrahyoid level. However, intrathyroid TGDC in the adult is extremely rare and its pathogenesis remains unclear. Curiously, an intrathyroid TGDC was found on the lateral aspect of the inferior pole of the thyroid gland. Given the unique position of this lesion, and its capacity to stimulate other nodules in the thyroid, it should be differentiated from other lateral neck masses, such as: thymic cysts, branchial cleft cysts, cystic hygroma, lipomas, lymphadenopathies, cervical teratomas, and lymphomas. In this case, a separate cystic mass was found in the right inferior pole of the thyroid gland and extended to the mediastinum. We confirmed it as TGDC by pathology and histological examination.
A Comparative Study on the Application of Text Mining in Cybersecurity
Authors: Barik Kousik , Misra Sanjay , Konar Karabi , Kaushik Manju , Ahuja Ravin
Published: June 2022

Aims:

This paper aims to conduct a Systematic Literature Review (SLR) of the relative applications of text mining in cybersecurity.

Objectives:

worldwide has been attributed to a change in the different activities associated with cyber security and demands a high automation level.

Methods:

In the cyber security domain, text mining is an alternative for improving the usefulness of various activities that entail unstructured data. This study searched databases of 516 papers from 2015 to 21. Out of which 75 papers are selected for analysis. A detailed evaluation of the selected studies employs source, techniques, and information extraction on cyber security applications.

Results:

This study extends gaps for future study such as text processing, availability of datasets, innovative methods, intelligent text mining.

Conclusion:

This study concludes with interesting findings of employing text mining in cybersecurity applications; the researchers need to exploit all related techniques and algorithms in text mining to detect and protect the organization from Cybersecurity applications.
Caritative Innovation: Fundraising and Crowdfunding
Authors: Semenov I. A.
Published: June 2022

The relevance of the study is due to the fact that the process of digitalization is integrated into the entire set of sectors of the national economy, which is directly related to maintaining the proper level of well-being of the population. Charity, including caritative activities, is also subject to digitalization. The author considers fundraising and crowdfunding as a tool for digital socially transformative investment. The elements and the mechanism of financial transactions for online charitable donation are presented, their functionality is described in symbiosis with web services.

The purpose is to identify and structure the essential features of innovative forms of caritative activity: fundraising and crowdfunding.

Objectives: to reveal the concepts: "innovative forms of caritative activity", "fundraising" and "crowdfunding"; to analyze the algorithm of functioning of innovative forms of caritative activity, as well as to predict the ways of their further development in the future.

Methodology. The methodological basis of the study is based on the ontological, socio-economic approach, as well as other and other approaches, generalized by the dialectical method, in the study of the innovative field of caritative activity.

Result. Result of the work carried out, the essence, as well as the mechanism for implementing innovative forms of caritative activity, is considered, a model of interaction between participants in fundraising and crowdfunding relations is derived. The socio-philosophical aspect of caritative activity is presented.

Conclusions. Socially transformative investment is an important element of the digitalization of philanthropy, which is prominently expressed in the form of fundraising and crowdfunding. With the successful implementation of innovative forms of caritative activity and their introduction into practice, the speed of solving financial problems related to fundraising, as well as the completeness of coverage of the audience interested in caritative assistance, significantly increases.
The Ontological Status of an Artistic Image on the Example of Acting (II): Creation of a Stage Image
Authors: Sinitsyna T. A.
Published: June 2022

Relevance. In this work we continue to develop the range of problems raised in the first article, which shows that the ontological status of an artistic image is made up of its "materiality", sign-symbolic and metaphysical components. An urgent problem for the theory and philosophy of the theater is the development and substantiation of the processes of synthesis of the imagination and physicality of the actor in practice, in the embodiment of the stage image.

The purpose is on the basis of the philosophical and methodological analysis of theatrical practice we are going to show that the embodiment of a stage image in a theatrical performance is possible only under the condition of a joint maximum concentration of perception, both by the actor and the spectator.

Objectives: on the basis of various theatrical concepts and ideas of quantum-synergetic anthropology we plan to consider the formation of a stage image in practice; to reveal the relationship of the ontological status of this image with the problem of the unity of consciousness and body; to identify the features of the audience's perception of the game and the unique characteristics of theatrical practice as a post-non-classical practice.

Methodology. Historical and philosophical approach to the problems of perception and the correlation of corporality and consciousness; philosophical reflection, hermeneutical method, methodology of generalized corporeality in quantum-synergetic anthropology.

Results. The concept of a creative impulse of a theatrical action is introduced as an interpretation of the concept of A. Bergson's creative impulse in theatrical practice. As a result of the study, it was found that the completeness of the perception of the stage image mainly depends on the integrity of the states of the actor's generalized corporeality in the acts of the "creative impulse" of the theatrical action.

Conclusions. The theatrical production gives the viewer much less space for interpretation (compared to other non-stage art forms) in the process of being captured by the general action, although, of course, it does not completely deprive him of this freedom. The ontological status of the stage image represents the integrity of the processes of the generalized corporality of the actor and the audience's perception.
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Authors: JNTETI
Published: June 2022

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A Sociolinguistic Analysis of Taboo Words in Deadpool 2
Authors: Rahmania Salsabila , Munandar Aris
Published: June 2022

The purpose of this research is to describe the types and functions of taboo words uttered by the characters, and describe the social background that affect the main character’s utterances in Deadpool 2. The data are utterances containing taboo words. The analysis focuses on the types and functions of taboo words by applying Azzaro’s (2005) theory. The finding shows, 1) there are five types of taboo words in use. The most frequently used taboo is Sexual term with 70 occurrences (52.2%), followed by physical term with 23 occurrences (17.2%), religious term with 21 occurrences (15.7%), scatological term with 17 occurrences (12.7%), and mental term with 3 occurrences (2.2%). 2) There are two functions of taboo words: swearing with 82 occurrences (64%), and insult with 46 occurrences (36%). 3) There are two social variables that affect the main character’s use of taboo words: occupational hierarchy and social status.
Lexical Error Analysis of Indonesian-English Translation of Texts in Dewantara Kirti Griya Museum
Authors: Swadeshi Ahimsa W. , Sutrisno Adi
Published: June 2022

The current research aims to examine lexical errors in Indonesian-English translated texts in Museum Dewantara Kirti Griya. The classification of Lexical Errors proposed by Legenhausen (1975, as cited in James, 2013) is applied in analysing the texts. From 43 texts, the result indicates that there are 88 errors, classified into formal errors (62,5%) and semantic errors (37,5%). The first one deals with the arrangement of words and phrases, while the second deals with meaning and collocation. The most common errors are about the confusion between concepts and terms. This happens when the translator meets local-cultural terms in the SL that needs extra effort to translate.
Hydrological Risk Mitigation from Natural Hazards in Ojirami Dam Edo State Nigeria
Authors: Abulime Jonathan , Obokparo Ikri Samuel
Published: June 2022

The objective of this paper works is to analyze the rainfall and runoff discharge of the Ojirami dam area, and effective modeling and simulation of hydraulic parameters in water distribution network and design of hydraulic structure (Reservoir water tank). The engineering tools used in this research work are EPANET PROGRAM, AUTOCAD, GOOGLE EARTH and GIS for portable pipe born-water supply, regarding to the relief of the inhabitants towards mitigation of risk from natural hazard, by protecting lives and properties against diseases: such as cholera and dysentery. During investigation and modeling the water network, the following climatic elements are defined: monthly and annual rainfall, maximum wind velocity for prevailing direction, free water surface evaporation, air temperature, relative humidity and sediment transportation. The capacity of the reservoir of the Ojirami dam is equal to 5 Mcm (5 X 106) the dam height of 7m and is located within Akuku community boundaries, Akoko-Edo Local Government Area, Edo-State. The area has a moderate slope around the dam too steep in higher parts of the dam. Due to proper researched on the internet and other information collected from Edo state water board and relevant statistics data from census of Nigeria. The dam was constructed across Onyami river the output capacity of the reservoir is about 473m3 per/hr. The construction dam is used as a source to supply water to the water distribution network. Google earth was used to generate toposheet of Akoko-Edo Local Government boundary, while Geographic information system was used to create Nigeria local government map and boundaries, due to local government shapefile data of Nigeria. Epanet program was used to digitalized the water network, which is based on census data and to estimate water demand. The Epanet tracks the flow of water in each pipe, the pressure at each node, the height of water in the tanks, and the concentration. The preliminary modeling of the (WDN) concluded that the water distribution network is sufficient to supplied water to communities. The water quality and the cost of modeling the water distribution network (pipe network) were estimated.
Convergence of an iteration scheme in convex metric spaces
Authors: Haokip Nehjamang
Published: June 2022

In this paper, a new iteration scheme in a uniformly convex metric space is deﬁned and its convergence is obtained. A numerical example is also considered to compare the rate of convergences of the iteration with that of an existing iteration scheme.
Profiled polyethylene terephthalate filaments that incorporate collagen and calcium phosphate enhance ligamentisation and bone formation
Authors:   School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University No. 17, Xuzhou Road, Zhongzheng District, Taipei 10055, Taiwan, Tai CC , Huang CC , Chou BH , Chen CY , Chen SY , Huang YH , Sun JS , Chao Y-H
Published: June 2022

Polyethylene terephthalate (PET) artificial ligaments offer an unlimited source of ligaments without donor-site-related morbidity and with good mechanical properties for a rapid return to sporting activities. Developing PET artificial ligaments with excellent ligamentisation and ligament-bone healing is still a considerable challenge. This study aimed to investigate the effects of the profiled PET/collagen/calcium phosphate (PET/C/CaP) ligament upon cell growth, ligamentisation and ligament-bone healing in vitro and in vivo. Profiled PET/C/CaP filaments were made by melt-spinning process with 2 % CaP hybrid spinning and collagen coating. Rat mesenchymal stem cells (MSCs) were cultured on the profiled PET/C filaments for cytotoxicity, viability, scanning electron microscopy (SEM) and ligament-related gene expression analysis. MSCs’ osteogenic capacity on the profiled PET/CaP filaments was identified by detecting osteogenic gene expression and alizarin red S staining. For in vivo verification, an animal study was performed to evaluate the effect of the profiled PET/C/CaP ligament in a rabbit knee medial collateral ligament reinforcement reconstruction model. The graft ligamentisation and bone formation were investigated by SEM, histology, microcomputed tomography and mechanical tests. The profiled PET/C filaments enhanced MSC proliferation and ligament-related gene expression. Furthermore, they enhanced osteogenic gene expression, alkaline phosphatase activity and mineralisation of MSCs. The in vivo study indicated that the profiled PET/C/CaP ligament enhanced ligamentous matrix remodelling and bone formation. Therefore, their use is an effective strategy for promoting MSCs’ ligamentous and osteogenic potential in vitro and enhancing ligamentous matrix remodelling and bone formation in vivo.