bluuebunny/crossref_metadata_2025 huggingface dataset:
Efeito de treinamento de memória de trabalho em crianças sem diagnósticos de comprometimento cognitivo, estudantes das séries iniciais do Ensino Fundamental / Working Memory Training Effect in Elementary School Children Without Diagnosis of Cognitive Impairment
Authors: Mascarello Lidiomar José
Published: November 2018

Resumo: O propósito principal deste artigo é apresentar resultados de pesquisas que mostram a relevância de um treinamento da memória de trabalho em crianças sem diagnóstico de déficit de atenção ou outras complicações cognitivas. São crianças estudantes do segundo ano do Ensino Fundamental em processo inicial de aprendizagem de leitura e escrita. Participaram do estudo 165 sujeitos. Todos os participantes foram submetidos a pré e pós testes que avaliaram índices de memória de trabalho e desempenho em leitura silenciosa de palavras e pseudopalavras. Além da apresentação dos resultados objetivamos discutir questões referentes a estudos da memória de trabalho (MT) e suas implicações nos processos de aprendizagem de leitura. Os resultados das pesquisas indicam que crianças com maior capacidade de memória de trabalho apresentam melhor desempenho em tarefas de leitura que crianças com menor capacidade nessa memória, tais resultados são consonantes a outros estudos na área.Palavras-chave: memória de trabalho; efeito de treinamento; leitura.Abstract: This study aims to present research results that show the relevance of work memory training in children without a diagnosis of attention deficit or other cognitive complications. They are children of the second year of the Elementary School in the initial process of learning to read and write. 165 subjects participated in the study. All participants were submitted to pre and post tests that evaluated work memory indices and performance in silent word and pseudoword reading. In addition to the presentation of the results, we aimed to discuss issues related to working memory (TM) studies and their implications for reading learning processes. The results of research indicate that children with higher working memory capacity perform better on reading tasks than children with lower memory capacity, such results are consonant with other studies in the area.Keywords: working memory; training effect; reading.
Halliday’s Mood System: A Scorecard of Literacy in the English Grammar in an L2 Situation / O sistema de modo de Halliday: um quadro de resultados sobre o conhecimento da gramática da língua inglesa como L2
Authors: Dalamu Taofeek Olaiwola
Published: November 2018

Abstract: It is no gainsaying that English is not only renowned in world affairs; its hegemony over other languages seems incontestable, and perhaps, unchecked. The domineering behavior has persuaded an L2 speaker to seek the knowledge of the language at all costs. It is fascinating to propose that the Halliday’s mood system could play a vibrant role in the understanding of the structures of English. This basis inspired the study to elucidate the arms of the mood system as consisting of grammatical structures of declarative, imperative, and interrogative; semiotic domains of Mood and Residue; and interpersonal grammatical transposition of MOOD. For a practical purpose, the study examined ten texts of advertisements processed through the mood system. The analysis revealed the verbal group as containing the finite and the predicator. Moreover, in a situation of fusion, both Finite and Predicator shared the verbal functional entity in terms of tense and natural ‘process’ statuses. Furthermore, Subject, Finite, Predicator, Complement, and Adjunct (SFPCA) are the components of the declarative, Predicator, Complement, and Adjunct (PCA) represent the jussive imperative; and SPCAs are units of the suggestive imperative. The study suggested that the appreciation of mood systemic sequences could quicken an L2 speaker to a better-cum-fuller understanding of English grammatical system.Keywords: English grammar; language acquisition; language learning; literacy; mood system.Resumo: Não é novidade que o inglês é reconhecido mundialmente; sua hegemonia parece incontestável e talvez, sem julgamento. A dominância dessa língua persuade seus falantes como L2 a buscarem conhecimento sobre ela de todas as formas. É fascinante propor que o sistema de modo de Halliday poderia ter um papel importante na compreensão das estruturas do inglês. Essa ideia inspirou esse estudo a elucidar o papel do sistema de modo, o qual consiste de estruturas gramaticais declarativas, imperativas e interrogativas; que pertencem ao domínio semiótico de Modo e Resíduo e à transposição gramatical interpessoal de MODO. Para o estudo dez testos de propagandas foram processados através do sistema de modo. A análise revelou que o grupo verbal contém formas Finitas e Predicadores. Ademais, numa situação de fusão, ambos o sistema Finito e Predicador dividiam a função verbal de entidade funcional em termos de tempo e processos naturais. Além disso, Sujeito, Finito, Predicador, Complemento e Adjunto (SFPCA) são componentes de declarativas; Predicador, Complemento e Adjunto (PCA) representam o imperativo jussivo; e SPCAs são unidades do imperativo sugestivo. O estudo sugere que a observação de sequências sistêmicas de modo poderiam agilizar o conhecimento de um aprendiz de inglês L2 do sistema gramatical da língua.Palavras-chave: gramática do inglês; aquisição de língua; aprendizagem de língua; letramento; sistema de modo.
O enunciado verbovocovisual “Guerra do Rio”, do Jornal Extra: o signo ideológico “Guerra” em estudo / The Verbivocobisual Utterance “Guerra do Rio”, of the Jornal Extra: the Ideological sign “War” in Study
Authors: Stafuzza Grenissa Bonvino , Diniz Giovanna dos Santos
Published: November 2018

Resumo: Aborda-se no presente estudo algumas contribuições teóricas do Círculo de Bakhtin para a análise de enunciados verbovocovisuais, uma vez que o discurso tomado como objeto de análise se constitui e se realiza por elementos verbais, vocais e visuais em um todo arquitetônico que significa. Sob essa perspectiva, analisa-se o enunciado “Guerra do Rio” que constitui a editoria do Jornal Extra lançada em 2017, composto por três materialidades – i) o vídeo intitulado “Isso não é normal”, publicado no site do Jornal Extra; ii) o editorial e; iii) a capa do Jornal Extra –, considerando os sentidos que emanam do signo ideológico guerra na construção do discurso jornalístico sensacionalista do jornal em questão.Palavras-chave: Círculo de Bakhtin; enunciado verbovocovisual; discurso jornalístico sensacionalista; Jornal Extra.Abstract: This study addresses some theoretical contributions of the Bakhtin Circle for the analysis of verbivocovisual utterances, since the discourse taken as object of analysis is constituted and put into practice by verbal, vocal and visual elements in an architectonic whole which means. From this perspective, we analyzed the utterance “Guerra do Rio”, which constitutes the editorial of the newspaper Extra launched in 2017, composed of three materialities – i) the video entitled “Isso não é normal”, published in the website of the Extra; ii) the editorial e; iii) the cover of Jornal Extra –, considering the senses that emanate from the ideological sign war in sensationalist journalistic discourse of the newspaper in question.Keywords: Bakhtin Circle; verbivocovisual utterance; sensationalist journalistic discourse; Jornal Extra.
Mulher, verão e cerveja: a produção de sentidos na peça publicitária da cerveja Itaipava, no Brasil / Women, Summer and Beer: The Production of Meanings in the Itaipava Adds, in Brazil
Authors: Sousa Tatiana Barbosa de , Andrade Guilherme Beraldo de
Published: November 2018

Resumo: Com o intuito de analisar o funcionamento de sentidos produzidos pela excessiva exposição da imagem da mulher como apelo comercial nas propagandas da marca Itaipava no Brasil e compreender como se dão os efeitos de sentidos causados pelo uso da imagem da mulher no meio publicitário, analisaremos recortes de peças publicitárias desta marca, tomando como base teórica a semântica histórica da enunciação, tal como proposta por Guimarães, além de outros conceitos fundamentais para este estudo que se estabelece em diálogo constante com a análise de discurso. Neste artigo, compreendemos como o processo de produção de sentidos se dá em outras formas significantes para além do texto e como esses efeitos de sentido afetam, direta e indiretamente, o comportamento do homem na relação para/com a mulher na nossa sociedade.Palavras-chave: semântica histórica da enunciação; análise de discurso; imagem da mulher; efeitos de sentido.Abstract: In order to observe the work of meanings that are produced by the excess of the image of the women as a commercial appeal in the advertisings made by the brand Itaipava in Brazil, and understand how the effects of meanings caused by the use of the image of women in the marketing area we will analyze pieces of advertisement used by this brand, having as the theoretical basis the studies in the Historical Semantics of Enunciation, as presented by Guimarães, besides other essential concepts to this study that is established in the constant possible dialogue with the discourse analysis. In this article, we try to understand how the process of production of meanings happen in other meaningful ways that are out of the text, and how these meaning effects affect, directly and indirectly, the behavior of the men in relation to/with the women in our society.Keywords: historical semantics of enunciation; discourse analysis; women image; effects of meaning.
Cronotopia: um fenômeno de largo espectro / Chronotopy: A Broad-Spectrum Phenomenon
Authors: Furlanetto Maria Marta
Published: November 2018

Resumo: Este estudo tem o objetivo de explorar o fenômeno da cronotopia a partir de seu inacabamento teórico, conforme a experiência realizada por Bakhtin com o gênero romance, abrindo vias para estudiosos da área. Estabelece vínculos com campos de estudo das ciências sociais e da linguagem e propõe um olhar que parte da concepção de metáfora como figuração, abordando autores que perspectivaram o tempo e o espaço em contextos histórico-sociais. A título de experiência de abordagem, mostra uma possibilidade de análise cronotópica (estudo de caso), estabelecendo um quadro em que faz convergir o olhar sociológico, histórico, discursivo no panorama cultural, modo de funcionamento dos cronótopos para estudo figurativo da vida social.Palavras-chave: figuração; metáfora; cultura.Abstract: This study aims to explore the phenomenon of chronotopy from its theoretical unfinishing, according to Bakhtin’s experience with the novel, opening ways for scholars of this area. It establish links with fields of study of social sciences and language and proposes a view that starts from the conception of metaphor as figuration, approaching authors who have looked at time and space in historical and social contexts. As an experience of approach, it shows a possibility of chronotopic analysis (case study), establishing a framework in which converges the sociological, historical, discursive look in the cultural panorama, mode of functioning of the chronotopes for the figurative study of social life.Keywords: figuration; metaphor; culture.
Electrocardiographic Changes in Athletes of Black Ethnicity
Authors: Ismail Dillan , Eriksson Anders , Mörner Stellan , Rydberg Annika
Published: November 2018

AbstractIntensive participation in sport has positive physiological effects on the heart. The contractility of the heart improves, the ejection fraction increases and the muscle mass of the heart increases, thus leading to a greater cardiac output. Despite these positive effects, there is still an increased risk for acute cardiac events. The workload of the heart can be very high in some sports and may in some cases be the reason for sudden cardiac death. In these cases, there is often an underlying heart disease (cardiomyopathy) unknown before the actual event. Electrocardiographic examination (ECG) may reveal some of these diseases but although ECG examinations can be a useful tool to discover pathological conditions, there could be difficulties in interpreting different ECG patterns, especially in athletes. In some cases, athletes may exhibit ECG patterns that are similar to those in heart diseases such as cardiomyopathies (QRS-amplitudes, ST-segment elevation and T wave inversions in lateral leads).  This pattern is even more common in athletes of African origins. Furthermore, cardiomyopathies such as hypertrophic cardiomyopathy (HCM) are more common among athletes with African heritage than in white athletes. Thus correct interpretation of ECG is crucial for several reasons: to distinguish between benign physiological (‘athlete’s heart’) and pathological changes, to lower the risk of sudden cardiac death, and to save time and money by not undertaking further examination of the heart.
Authors’ Responsibilities and Ethical Publishing
Authors: Shewan Louise Gabrielle , Stewart Coats Andrew J. , Henein Michael
Published: November 2018

The International Cardiovascular Forum Journal requires authors to abide by the following guidelines:Manuscript: The corresponding author declares that the manuscript has not been published and is not under consideration elsewhere.Authorship: The corresponding author takes full responsibility for the list of authors.  Any modification to the author list including order and composition can only be approved by the Editor-in-Chief following signed agreement from all the authors listed on the original submission.Ethics: The corresponding author states that the material presented has been obtained with the approval of all appropriate animal and/or human ethics committee(s).Permissions: The corresponding author on behalf of all authors confirms whether explicit written consent to publish has been received from any people described, pictured, or recorded and that formal copyright clearance is obtained to publish any video or audio recordings.Registration of Clinical Trials: Prospective registration of any clinical trial in a publically accessible database is a requirement for later publication of such trials in ICFJ. In exceptional circumstance if the trial is not registered, or is registered retrospectively, the reasons for this must be given.Competing Interests: All authors must declare all relevant competing interests (financial, or non-financial, professional, or personal) and state all funding sources.Attribution: The corresponding author accepts full responsibility for the accurate citation and acknowledgement of any material reproduced from other publications including the author’s own prior work.It is incumbent upon the corresponding author to consult the Editor-in-Chief should there be any variance of the above. The Editor-in-Chief retains the right to retract any submission found to be in breach of the above guidelines.
Proximate, Mineral, Vitamin Compositions, Mineral Safety Index and Mineral Ratios of the Flesh of Heterosexual Pairs of Neopetrolisthes maculatus
Authors: Adeyeye Emmanuel Ilesanmi , Omolara Adubiaro Habibat
Published: November 2018

The flesh of female and maleNeopetrolisthesmaculatuswas used for the determination of proximate, minerals, vitamins compositions, mineral safety index (MSI) and mineral ratios (MRs). The values of crude fat, carbohydrate, total ash, moisture and fatty acid were more concentrated in the female than male sample. These parameters: crude protein, carbohydrate, total ash and moisture were relatively high in both samples. The coefficient of variation percent (CV %) values ranged between 2.57 - 10.9 showing the value variations to be low. Both the total metabolisable energy and utilizable energy due to protein were higher in male than in female as shown: 1078 kJ 100g-1(male) >1055 kJ100g-1(female) and 41.3 (male) > 38.8 (female). All the mineral levels in the female sample were higher than in the male sample. These minerals were of high concentration (mg 100g-1) in the samples: Cu (15.9 - 16.3), Mn (5.73 - 6.21), Ca (542 – 562), Mg (652 – 682), K (317 – 329), Na (395 – 413) and P (1132 – 1143). Most of the mineral ratios were very low when compared to the ideal, those that were high were much higher than the ideal, and they were: Ca/Pb (492631 – 562195; ideal (id) = 84.0), Fe/Pb (1685-2083; id =4.40) and K/Co (1919-2082; id =2000) but values in Zn/Cd and Fe/Co were high but lower than the ideal values as shown: Zn/Cd (207 – 238; id =500) and Fe/Co (12.2-12.2; id =440). High mineral ratios were mainly observed in ratios involving trace elements. Mineral safety index of major concern in nutrition was observed in Mg and Cu in both samples. However the MSI aberration was more pronounced in the female than in the male. In the vitamin profiles niacin (B3) was the only vitamin higher in value in male than female out of eleven vitamin parameters determined. B3in male was just 3.48% greater than in female whereas vitamins that had higher values in female than in male had higher percentage values that ranged between 4.22 - 15.0. All these parameters were significantly different at r= 0.01between the two samples: proximate, percentage energy distribution, mineral, mineral ratios and vitamin composition. On pairwise comparison, the parameters determined were more concentrated in the female that the male; this could be due to the biological function of the female as a “mother crab”.
Do young children prohibit mothers from working? A study in the Amhara Region, Ethiopia
Authors: Desta Chalachew Getahun
Published: November 2018

Theoretical work relating economic effect of children suggests that labor market participation decreases for mothers with large number of young children and increases when children are adults. The majority of empirical studies find results consistent with this expectation, but there are some studies which fail to confirm this theoretical prediction for the developing countries. This paper used data from a household survey of rural and urban married women to test the theoretical prediction that labor market participation decreases for mothers with large number of young children and increases when children are adults. Results show that when all households are considered, children seem to have positive effects on the probability of the mother’s work participation. However, when household lifecycle and rural-urban location differences are considered, coefficients are negative (but not statistically insignificant) for urban households with large number of young children and positive (and statistically significant) for those households with more adult children; whereas for rural households, these coefficient signs are reversed. Results from the quantitative data combined with qualitative narratives suggest that large numbers of young children do not prohibit rural mothers from working.
CARACTERIZAÇÃO DAS PESSOAS COM DOENÇA FALCIFORME EM UMA CIDADE DO ESTADO DA BAHIA
Authors: Da Silva Souza Rodrigues Catharinne , Silva Gomes Xavier Aline , Moreira Carneiro Jayanne , Damasceno Silva Tamillys , Lima Machado de Souza Araújo Roberta , Da Silva Santos Passos Silvia
Published: November 2018

Objetivo: caracterizar as pessoas assistidas em um Centro de Referência em doença falciforme em uma cidade do estado da Bahia. Método: estudo quantitativo, descritivo e retrospectivo, realizado entre agosto de 2016 e fevereiro de 2017. Os dados secundários coletados em 326 prontuários foram processados no STATA, versão 12.0. Resultados: prevalência de adultos jovens, do sexo feminino, solteiras, pretas, com renda de até um salário mínimo, não alfabetizadas, protestantes, com até três filhos. As complicações prevalentes foram crise álgica, icterícia e alterações do baço. As medicações mais utilizadas foram ácido fólico, hidroxiureia, ibuprofeno e dipirona. Permaneceram em tratamento 67,79% das pessoas, enquanto 4,60% foram a óbito. Conclusão: pessoas com doença falciforme assistidas em um centro de referência possuíam elevado grau de vulnerabilidade e estavam sujeitas à variabilidade clínica.
Descritores: Doenças de células falciformes. Perfil de saúde. Epidemiologia.
Mood disorder following traumatic brain injury: a case report
Authors: KOPARAL Buket , COŞAR Behçet
Published: November 2018

Traumatic brain injury is a clinical situation that
generally affects young people aged 45 years or younger and causes mortality
and critical functional losses. The most common psychiatric disorder following taumatic
brain injury is depression. Although the relationship between depression and
organic diseases has been studied a lot, there is less data about mania.
Secondary mania differs from primary mania with advanced beginning age, absence
of family history, more difficult and slower response to treatment; and
secondary mania usually has no recurrence. In this report, secondary mania and
its clinical features are discussed in light of a mood disorder following a
trauma case. The case is still followed with mood stabilizer treatment and the
patient is euthymic.
Health and Establishment of Highway Plantings in Florida (United States)
Authors: Blair Seth , Koeser Andrew , Roman Lara , Knox Gary , Thetford Mack
Published: November 2018

Urban tree planting initiatives can experience high levels of mortality during establishment years. Mortality tied to the stresses of transplanting can be partially negated or exacerbated depending on the species selected, nursery materials used, site conditions present, and management practices employed. Past research has quantified post-planting survival, health, and growth. However, varying climates, species, land use types, and management practices warrant additional region-specific research. The purpose of this study is to assess the success of plantings along Florida highways and identify species, site, and management factors related to tree and palm health and establishment. Results show high annual establishment survival (98.5%) across 21 planting projects ranging from 9 to 58 months after installation, (n = 2711). For transplanted palms, the presence of on-site irrigation significantly improved establishment from 96.2% to 99.4%. No establishment differences were detected with regard to irrigation treatment for small-stature trees, shade trees, and conifers. Additionally, there were significant differences in tree health response among tree groups given species, management, and site factors.
GDP modelling: assessment of methodologies and peculiarities of its usage in Ukraine
Authors: Kvasha Serhii , Davydenko Nadiia , Pasichnyk Yurii , Viatkina Tetiana , Wasilewska Natalia
Published: November 2018

GDP is one of the main indicators determining the level of economic growth in countries and regions across the globe, therefore, its calculation should be based on the advanced methodology. In the present context, the existing methods of the GDP calculation do not fully meet the fineness criterion subject to certain objective and subjective reasons. Hence, the development of more perfect methodology that takes into account the disadvantages of the existing techniques and is based on economic and mathematical modeling is an urgent national task for Ukraine. The purpose of the article is to assess the GDP calculation methodology used in Ukraine. To achieve this purpose, the relevant methods of GDP calculation, which are valid in Ukraine, have been analyzed, their specifics, certain drawbacks, problems of use and application scenarios have been also revealed. According to the analysis results, an advanced methodology based on an economic and mathematical model with the use of dynamic programming is proposed. The developed methodology for calculating the GDP takes into account the peculiarities of social development in Ukraine and the tendencies of world economic processes and contributes to obtaining more reliable GDP values. It will be useful for experts in financial institutions, including international ones, and scholars working in the macroeconomic modeling area.
Emerging Trends in Advanced Nanomaterials Based Electrochemical Genosensors
Authors: Kaushik Mahima , Khurana Sonia , Mehra Komal , Yadav Neelam , Mishra Sujeet , Kukreti Shrikant
Published: November 2018

Advanced nanomaterials indubitably represent one of the most propitious class of new materials due to
their intriguing optical, electronic and redox properties. The incredible progress achieved in this research area has
been propelled by the development of novel synthetic procedures owing to the emergence of nanotechnology and
by the wide range of applications. These nanostructured materials possess high surface area, biocompatibility,
nontoxicity and charge-sensitive conductance which have led to the development of simple, rapid, highly
sensitive, inexpensive and portable electrochemical genosensors. This review accentuates on the development and
validation of various advanced nanomaterials based electrochemical genosensors that utilize unique properties of
nanomaterials for signal transduction purpose or as an electroactive species for direct detection of analyte. The
intent is to highlight the recent progress on highly sensitive and flexible nanostructured material based
electrochemical genosensors that have the potential to be developed as the next generation field-deployable
analytical tools.
Alterations in the Expression of Amyloid Precursor Protein Cleaving Enzymes mRNA in Alzheimer Peripheral Blood
Authors: Wongchitrat Prapimpun , Pakpian Nattaporn , Kitidee Kuntida , Phopin Kamonrat , Dharmasaroja Pornpatr A. , Govitrapong Piyarat
Published: November 2018

Background:

Alzheimer’s disease (AD) is the most common cause of dementia in elderly
populations. Changes in the expression of the Amyloid Precursor Protein (APP)-cleaving enzymes directly
affect the formation of Amyloid Beta (Aβ) plaques, a neuropathological hallmark of AD.

Objective:

We used peripheral blood from AD patients to investigate the expression of genes related to
APP-processing [(β-site APP-cleaving enzyme 1 (BACE1), presenilin1 (PSEN1), and a disintegrin and
metalloproteinase family 10 (ADAM10) and 17 (ADAM17)] and the epigenetic genes sirtuin (SIRT)1-3,
which regulate Aβ production.

Method: Real-time polymerase chain reactions were performed to determine the specific mRNA levels
in plasma. The mRNA levels in AD patients were compared to those in healthy persons and assessed in
relation to the subjects’ cognitive performance.

Results:

BACE1 mRNA level in AD subjects was significantly higher than those of healthy controls,
whereas ADAM10 level was significantly lower in the AD subjects. The SIRT1 level was significantly
decreased, while that of SIRT2 was increased in AD subjects and elderly controls compared to levels in
healthy young control. In addition, correlations were found between the expression levels of BACE1,
ADAM10 and SIRT1 and cognitive performance scores. Total Aβ (Aβ40+Aβ42) levels and the Aβ40/Aβ42
ratio were significantly increased in the AD subjects, whereas decrease in plasma Aβ42 was found in AD
subjects. There was a negative correlation between Aβ40 or total Aβ and Thai Mental State Examination
(TMSE) while there was no correlation between Aβ40/Aβ42 ratio or Aβ42 and TMSE.

Conclusion:

The present findings provide evidence and support for the potential roles of these enzymes
that drive Aβ synthesis and for epigenetic regulation in AD progression and development, which can
possibly be considered peripheral markers of AD.
An Environmentally-Benign Synthesis of Spiro-benzo[1,4]diazepines Using Multi Phase Nano-titania as a Highly Efficient Catalyst via MAOS Technique
Authors: Gupta Sharoni , Punjabi Pinki B. , Ameta Chetna , Ameta Rakshit
Published: November 2018

Aim and Objective:

Benzodiazepines and indole fused heterocycles are pharmacologically
significant scaffolds. Trivial work on indole fused benzodiazepine compounds is reported in the literature.
Hence, it is imperative to explore the synthesis of indole-fused benzodiazepines that may act as a template for
biological studies in the future. Hence, in the present work, the synthesis of indole fused benzodiazepine
derivatives was undertaken using multi-phase nano-titania as catalyst under microwave irradiation.

Materials and Methods:

MAOS technique was used to carry out the synthesis of spiro-benzo [1,4]diazepine
derivatives in the presence of multiphase nano-titania as a catalyst. Nano-titania was prepared by sol-gel
method and characterized by XRD, FT-IR, FESEM, EDS and thermogravimetric techniques. The synthesized
spiro-benzo [1,4] diazepine derivatives were identified by physical and spectral methods.

Results:

Synthesized compounds were obtained in excellent yields in a short span of time. The synthesis was
also carried out in the presence of conventional catalysts in addition to nano-titania. Among all the catalysts,
the best result was obtained with nano-titania. The amount of nano-titania was optimized to be 0.05g giving 93-
95% yield of products. The study of reusability of nano-titania revealed that it could be reused up to four times
with a negligible change in efficiency.

Conclusion:

The paper reports an efficient, cost-effective and environmentally benign approach for the
synthesis of spiro-benzo [1,4] diazepine derivatives in the presence of multiphase nano-titania catalyst under
microwave irradiation.
Design, Synthesis, Antimicrobial and Anti-biofilm Evaluation, and Molecular Docking of Newly Substituted Fluoroquinazolinones
Authors: Zayed Mohamed F. , Ibrahim Sabrin R.M. , Habib EL-Sayed E. , Hassan Memy H. , Ahmed Sahar , Rateb Heba S.
Published: November 2018

Background:

Quinazolines and quinazolinones derivatives are well known for their
important range of therapeutic activities.

Objective:

The study aims to carry out the synthesis of some derivatives of substituted
fluoroquinazolinones based on structure-based design and evaluation of their antibacterial, antifungal,
and anti-biofilm activities.

Methods:

Compounds were chemically synthesized by conventional methods. Structures were established
on the basis of spectral and elemental analyses. The antimicrobial potential was tested
against various microorganisms using the agar disc-diffusion method. MIC and MBC as well as
anti-biofilm activity for the highly active compounds were assessed. Moreover, the computational
studies were performed using Auto dock free software package (version 4.0) to explain the predicted
mode of binding.

Results:

All derivatives (5-8), (10a-g), and (A-H) were biologically tested and showed significant
antimicrobial activity comparable to the reference compounds. Compounds 10b, 10c, and 10d had
a good MIC and MBC against Gram-positive bacteria, whereas 10b and 10d showed significant
MIC and MBC against Gram-negative bacteria. However, compounds E and F exhibited good
MIC and MBC against fungi. Compound 10c and 8 exhibited significant anti-biofilm activity towards
S. aureus and M. luteus. Molecular docking study revealed a strong binding of these derivatives
with their receptor-site and detected their predicted mode of binding.

Conclusion:

The synthesized derivatives showed promising antibacterial, antifungal, and antibiofilm
activities. Modeling study explained their binding mode and showed strong binding affinity
with their receptor-site. The highly active compounds 5 and 10c could be subjected to future
optimization and investigation to be effective antimicrobial agents.
Spirocyclohexadienones as an Uncommon Scaffold for Acetylcholinesterase Inhibitory Activity
Authors: Gomes Ralph C. , Sakata Renata P. , Almeida Wanda P. , Coelho Fernando
Published: November 2018

Background:

The most important cause of dementia affecting elderly people is the Alzheimer’s disease (AD). Patients affected by this progressive and neurodegenerative disease have severe memory and cognitive function impairments. Some medicines used for treating this disease in the early stages are based on inhibition of acetylcholinesterase. Population aging should contribute to increase the cases of patients suffering from Alzheimer's disease, thus requiring the development of new therapeutic entities for the treatment of this disease.

Methods:

The objective of this work is to identify new substances that have spatial structural similarity with donepezil, an efficient commercial drug used for the treatment of Alzheimer's disease, and to evaluate the capacity of inhibition of these new substances against the enzyme acetylcholinesterase.

Results:

Based on a previous results of our group, we prepared a set of 11 spirocyclohexadienones with different substitutions patterns in three steps and overall yield of up to 59%. These compounds were evaluated in vitro against acetylcholinesterase. We found that eight of them are able to inhibit the acetylcholinesterase activity, with IC50 values ranging from 0.12 to 12.67 µM. Molecular docking study indicated that the spirocyclohexadienone, 9e (IC50 = 0.12 µM), a mixedtype AChE inhibitor, showed a good interaction at active site of the enzyme, including the cationic (CAS) and the peripheral site (PAS).

Conclusion:

We described the first study aimed at investigating the biological properties of spirocyclohexadienones as acetylcholinesterase inhibitors. Thus, we have identified an inhibitor, which provided valuable insights for further studies aimed at the discovery of more potent acetylcholinesterase inhibitors.
Quantitative Determination of Ginsenoside Rg1 in Rat Plasma by Ultrahigh Performance Liquid Chromatography-tandem Mass Spectrometry (UHPLC-MS/MS) and its Application in a Pharmacokinetics and Bioavailability Study
Authors: Weng Qinghua , Zhang Zhenan , Chen Linglong , You Weiwei , Liu Jinlai , Li Feifei , Chen Lianguo , Jiang Xiajuan
Published: November 2018

Background:

Ginsenoside Rg1 (Rg1) is the main active compound of ginseng herbs.

Objective:

The aim of this study is to develop a rapid, selective and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method to determine the levels of Rg1 in rat plasma and investigate the pharmacokinetics and bioavailability of Rg1 in rats.

Methods:

Chromatographic separation was achieved on an UHPLC-MS/MS system with an UPLC BEH C18 column using an elution gradient of a mixture of acetonitrile and water (with 0.1% formic acid). The analytes were quantitatively determined by negative-mode electrospray tandem MS.

Results:

The linearity of the calibration curve was from 2 to 1,000 ng/mL (r ≥ 0.9956), and the lower limit of quantification was 2 ng/mL. The inter-day and intra-day precision were both lower than 12.0%, and the accuracy ranged from 90.6 to 109.7%. The recovery of the targets was higher than 87.0%, and the matrix effect at three different analyte concentrations were from 89.0 to 97.2%. The bioavailability of Rg1 was only 6.1% due to a poor oral absorption.

Conclusion:

This new quantitative method was found to be sensitive, rapid and selective, and was successfully used to study the pharmacokinetics of Rg1 after intravenous and oral administration in rats.
Delayed Hemolytic Anemia after Treatment with Artesunate: Case Report and Literature Review
Authors: Salehi Mohammadreza , Masoumi-Asl Hosein , Assarian Mehrdad , Khoshnam-Rad Niloofar , Haghi Afsaneh Motevalli , Nikbakht Mehran , Khalili Hossein
Published: November 2018

Background:

In recent years, few cases of post-artemisinin delayed hemolysis have been reported.

Objective:

All cases of post-artemisinin delayed hemolysis were reported from non-middle east areas.
No case of post-artemisinin delayed hemolysis has yet been reported from this region. In this paper, we
describe a case of post-artemisinin delayed hemolysis in an Iranian female. Moreover, previous reports
have been reviewed.

Methods:

Patient’s data including demographic characteristics, past medical, drug and travelling
history, present illness, vital signs, laboratory data, clinical course of current illness and follow-up
findings were considered.

Results:

A 27-year-old female with a recent travel history to Ghana admitted with severe falciparum
malaria. She was successfully treated with parenteral artesunate. However after 12 days of post
artesunate treatment, she returned with dark urine, malaise and fatigue.

Conclusion:

Considering the clinical course and base on a reliable causality assessment scale, post
artesunate delay hemolytic anemia was possible.
Withdrawal Notice: The Effectiveness of Hierarchical Structure on Cloud Systems
Authors: Alshamrani Sultan
Published: November 2018

The article has been withdrawn at the request of the authors and editor of the journal Recent Advances in Computer Science
and Communications.;

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
ImpulsePal: Developing a Smartphone App to Manage Food Temptations using Intervention Mapping. (Preprint)
Authors: van Beurden Samantha Barbara , Greaves Colin James , Lawrence Natalia Sophie , Abraham Charles , Smith Jane Rebecca
Published: November 2018

BACKGROUND

Impulsive processes driving eating behaviour can often undermine peoples’ attempts to lose weight and maintain weight loss.

OBJECTIVE

To develop an impulse management intervention to support weight loss in adults.

METHODS

Intervention Mapping (IM) was used to systematically develop the “ImpulsePal” intervention. The development involved: 1) a needs assessment including a qualitative study, service user workshops, a systematic review of impulse modification techniques, and consultations with intervention design and delivery experts; 2) specification of performance objectives, determinants, and change objectives; 3) selection of intervention strategies (mapping of taxonomy-related change techniques to the determinants of change); 4) creation of programme materials; 5) specification of adoption and implementation plans; 6) devising an evaluation plan.

RESULTS

Application of the IM Protocol resulted in a smartphone app-based intervention aimed at reducing unhealthy snacking, overeating, and alcoholic and sugary drink consumption. The app includes inhibition training, mindfulness techniques, implementation intentions (if-then planning), visuospatial loading, use of physical activity as a craving-management technique, and context-specific reminders. An “Emergency Button” was also included to provide access to in-the-moment support when temptation is strong.

CONCLUSIONS

ImpulsePal is a novel, theory- and evidence-informed, person-centred app to improve impulse management and promote healthier eating. Intervention Mapping ensured that all app components are practical operationalisations of change techniques that target our specific change objectives and their associated theoretical determinants. Using this approach enhances transparency, provides a clear framework for analysis and increases replicability as well as the potential of the intervention to accomplish the desired outcome of supporting weight loss.
Developing an mHealth App for Post-stroke Upper Limb Rehabilitation: Feedback from U.S. and Ethiopian Rehabilitation Clinicians (Preprint)
Authors: Hughes Charmayne , Padilla Alejandra , Hintze Amy , Mariscal Tatiana , Sera Michael , Weidner Sven , Ontiverso Jonathan , Peng Tony , Encarcion Aaron , Cruz Zeus , Warner Sam , Sany Kedir , Baye Moges
Published: November 2018

UNSTRUCTURED

Stroke is the leading cause of adult disability worldwide, with 70% of survivors exhibiting residual impairments of the upper limb that require frequent in-person visits to rehabilitation clinic over several months. This study explored rehabilitation clinician’s preferences for design features to be included in an mHealth-enabled app for post-stroke upper-limb rehabilitation. Data were collected via online survey, sampling participants from Ethiopia (n = 37) and the U.S. (n = 40). Survey results indicated that Ethiopian and U.S. rehabilitation clinicians have different opinions about the importance of design features that should be included in a stroke tele-rehabilitation system which are likely due to differences in culture, the availability of human and physical resources, and how the field of rehabilitation is organized and managed. Our results, thus, indicate that mHealth technologies but must be tailored to the geographical and cultural context of the end-users.
SMS-based family planning communication and its association with modern contraception and maternal healthcare use in selected low-middle-income countries (Preprint)
Authors: Ghose Bishwajit , Wang Ruoxi , Shangfeng Tang , Yaya Sanni
Published: November 2018

BACKGROUND

In recent years, there has been a growing interest surrounding mobile phone-based health communication and service delivery methods especially in the areas of family planning (FP) and reproductive health. However, little is known regarding the role of SMS-based FP communication on the utilisation of modern contraception and maternal healthcare services in low-resource settings.

OBJECTIVE

The objectives of this study were to 1) measure the coverage of SMS-based family planning (FP) communication, and 2) its association with modern contraception and maternal healthcare services (MHS) among mothers.

METHODS

Cross-sectional data on 94,675 mothers (15-49 years) were collected from the latest Demographic and Health Surveys on 14 low-and-middle-income countries. The outcome variables were self-reported use of modern contraception and basic MHS (timely and adequate use of antenatal care, and of facility delivery services). Data were analysed using multivariate regression and random effect meta-analyses.

RESULTS

The coverage of SMS-based FP communication for the pooled sample was 5.4% (95%CI=3.71, 7.21), and was slightly higher in Africa (6.04, 95%CI=3.38, 8.70) compared with Asia (5.23, 95%CI=1.60, 8.86). Among the countries from sub-Saharan Africa, Malawi (11.92, 95%CI=11.17, 12.70) had the highest percent of receiving SMS while Senegal (1.24, 95%CI=1.00, 1.53) had the lowest. In the multivariate analysis, SMS communication shown significant association with the use of facility delivery only (2.22 (95%CI=1.95, 2.83). The strength of the association was highest for Senegal (OR=4.70, 95%CI=1.14, 7.33) and lowest for Burundi (OR=1.5; 95%CI=1.01, 2.74). Meta analyses revealed moderate heterogeneity both in the prevalence and the association between SMS communication and the utilisation of facility delivery.

CONCLUSIONS

Although positively associated with using facility delivery services, receiving SMS on FP does not appear to affect modern contraceptive use and other components of MHS such as timely and adequate utilisation of antenatal care.
Скрытые опасности периоперационного периода: фокус на гипофосфатемии
Authors: Halushko О.A. , Babak S.I. , Bolyuk M.V.
Published: November 2018

Гипофосфатемия (ГФЕ) — одно из частых электролитных расстройств, для развития которого в периоперационном периоде существует много причин. Мы проанализировали базу данных Medline за последние 20 лет с целью идентификации статей, которые содержали бы в качестве одного из ключевых слово «гипофосфатемия». В поиск включили клинические и экспериментальные исследования, обзоры и сообщения о клинических случаях при наличии англоязычного резюме. Этот поиск дал 1754 публикации. На основе изученных статей нами были суммированы сведения о метаболизме фосфатов, основных клинических проявлениях ГФЕ, влиянии ГФЕ на течение периоперационного периода. Авторами представлен собственный опыт выявления и лечения ГФЕ. Определение уровней фосфатов проведено у 328 больных, перенесших хирургические вмешательства в операционных различного хирургического профиля. Наиболее высокая частота ГФЕ наблюдалась у ожоговых больных (23,08 %), после нейрохирургических (17,94 %) и абдоминальных (17,64 %) оперативных вмешательств. Установлено, что коррекцию ГФЕ тяжелой степени целесообразно проводить введением препарата D-фруктозо-1,6-дифосфата натрия — Эзафосфины. После проведенной коррекции препаратом уровень фосфатемии стабилизировался до референтных значений, что совпало с клиническим улучшением состояния пациентов. Больные в целом хорошо перенесли терапию Эзафосфиной, ни у одного из них не было зарегистрировано побочных эффектов.
Микробный пейзаж у больных острой парапневмонической эмпиемой плевры и оптимизация эмпирической антибактериальной терапии
Authors: Savchenko S.I.
Published: November 2018

Актуальность. Эмпиема плевры (ЭП), как и любое гнойно-воспалительное заболевание, требует назначения антибактериальной терапии и определения чувствительности микроорганизмов к антибиотикам. Однако микробный пейзаж и антибиотикорезистентность бактерий постоянно меняются. Это делает актуальным изучение спектра и свойств возбудителей ЭП. Цель исследования: изучить микробиологическую характеристику больных острой ЭП плевры и разработать рекомендации по оптимизации эмпирической антибактериальной терапии. Материалы и методы. Проведено комплексное ретроспективное исследование 124 случаев заболевания острой неспецифической парапневмонической ЭП. Мужчин было 92 (74,2 %). Медиана возраста больных составила 50,3 (38; 61) года. Результаты. При микробиологическом исследовании плеврального экссудата положительный результат получен в 34 (27,4 %) случаях. Необходимо отметить, что большинство больных (101 — 81,5 %) получали предшествующую антибактериальную терапию. Так, среди пациентов, ранее не получавших лечения, этот показатель был существенно выше — 12 (52,2 %) vs 22 (21,8 %), p < 0,01. Грамотрицательные и грамположительные микроорганизмы встречались одинаково часто — 19 (51,4 %) и 18 (48,6 %) изолятов соответственно. Среди причинной микрофлоры выделяются 5 основных возбудителей: Ps. aeruginosa, St. epidermidis, St. aureus, Str. pneumoniae, Str. mitis, которые суммарно составили 59,4 % изолятов. Выводы. Культуральные исследования при ЭП характеризуются значительным количеством негативных результатов (72,6 %). С учетом чувствительности основных возбудителей к антибиотикам рекомендованная эмпирическая антибактериальная терапия первой линии должна состоять из комбинации производных имидазола (метронидазол, орнидазол) и цефоперазона с сульбактамом. В качестве препарата второй линии целесообразно использование гатифлоксацина, а антибиотика резерва — гентамицина или тобрамицина.