bluuebunny/crossref_metadata_2025 huggingface dataset:
Tinea capitis caused by Trichophyton tonsurans among adults: Clinical characteristics and treatment response
Authors: Galili Eran , Goldsmith Tomer , Khanimov Israel , Arbel Chen , Sharvit Sharon , Lyakhovitsky Anna , Shemer Avner , Barzilai Aviv , Astman Nadav
Published: October 2022

Background

Trichophyton tonsurans tinea capitis has become a growing epidemiological concern. Yet, its clinical manifestations and treatment response, specifically among adults, have only been described among small sample size studies.

Objective

To assess clinical manifestations and treatment outcome of T. tonsurans tinea capitis among adults.

Patients and Methods

A retrospective cohort study was carried out among 111 adults with T. tonsurans tinea capitis. Diagnosis was confirmed by fungal culture or polymerase chain reaction. Examinees' demographics, disease characteristics and treatment response were measured. The risk factors for the treatment failure were evaluated.

Results

The mean age was 20.1 years (±3.1), with men (98.2%) outnumbering women. The follow‐up lasted 12.2 months (±5.6). The majority of T. tonsurans tinea capitis was seen in the occipital area (87.6%). In 78.9% of the cases, the scalp manifestation was non‐inflammatory (scaly plaques and papules:76.1% and seborrhoea‐like: 2.8%). 21.1% of cases presented with inflammatory tinea capitis (21.1%; Kerion: 10.1% and pustular: 11%). Concomitant involvement of other than scalp areas was common: tinea corporis was seen in 38.7% of the cases; tinea faciei and barbae in 24.3%; nape and anterior neck in 76.6% and 2.7% of the cases, respectively. An adequate treatment course with oral terbinafine resulted in 83.2% clinical cure rate. Treatment failure was significantly associated with concomitant tinea corporis (odds ratio 3.9; 95% confidence interval 1.3–12.1, p‐Value< .02).

Conclusion

The most common clinical presentation of T. tonsurans tinea capitis included occipital scaly plaques and papules with concomitant non‐scalp lesions. Oral terbinafine was found to be highly effective. Concomitant tinea corporis increased the risk for treatment failure.
Multi‐stress resilience in plants recovering from submergence
Authors: Yuan Li‐Bing , Chen Mo‐Xian , Wang Lin‐Na , Sasidharan Rashmi , Voesenek Laurentius A. C. J. , Xiao Shi
Published: October 2022

Submergence limits plants' access to oxygen and light, causing massive changes in metabolism; after submergence, plants experience additional stresses, including reoxygenation, dehydration, photoinhibition and accelerated senescence. Plant responses to waterlogging and partial or complete submergence have been well studied, but our understanding of plant responses during post‐submergence recovery remains limited. During post‐submergence recovery, whether a plant can repair the damage caused by submergence and reoxygenation and re‐activate key processes to continue to grow, determines whether the plant survives. Here, we summarize the challenges plants face when recovering from submergence, primarily focusing on studies of Arabidopsis thaliana and rice (Oryza sativa). We also highlight recent progress in elucidating the interplay among various regulatory pathways, compare post‐hypoxia reoxygenation between plants and animals and provide new perspectives for future studies.
Nor shadow of turning: Anthropological reflections on theological critiques of doctrinal change
Authors: Webster Joseph
Published: October 2022

To all intents and purposes, the Free Presbyterian Church of Scotland, the Brethren of Gamrie, and the Orange Order each claim a monopoly over theological truth, believing that they are right and that everyone else is wrong. Such a position is hardly exceptional – strong versions of pluralism take precisely this same monopolistic stance, calling, in effect, for a rejection of anything that rejects anything. Through an examination of such exceptionalist logics, this article seeks to provoke the anthropology of religion to ask certain questions about the social life of theological truth claims. Importantly, by asking anthropological questions (what makes a truth claim ‘stick’; what difference does it make in the world?), the anthropologist of religion is likely to encounter theological questions posed in response. Where does truth come from? What makes it true? What does such truth demand? While answering a question with another question is not always very revealing, this article suggests that in this case it might be, especially if some genuine attempt is made to answer the latter theological questions as a route to answering the former anthropological ones. More specifically, this article argues that anthropology might learn something about the nature of religious change, and changes to religious beliefs, if it first attempts to makes sense of (in this case, Protestant Fundamentalist) theological critiques of doctrinal change.
The vital role of arcuate nociceptin/orphanin FQ neurones in mounting an oestradiol‐dependent adaptive response to negative energy balance via inhibition of nearby proopiomelanocortin neurones
Authors: Sayers Sarah , Le Nikki , Hernandez Jennifer , Mata‐Pacheco Veronica , Wagner Edward J.
Published: October 2022

We tested the hypothesis that N/OFQ neurones in the arcuate nucleus (N/OFQARC) inhibit proopiomelanocortin (POMCARC) neurones in a diet‐ and hormone‐dependent manner to promote a more extensive rebound hyperphagia upon re‐feeding following an 18 h fast. We utilized intact male or ovariectomized (OVX) female mice subjected to ad libitum‐feeding or fasting conditions. N/OFQARC neurones under negative energy balance conditions displayed heightened sensitivity as evidenced by a decreased rheobase threshold, increased firing frequency, and increased burst duration and frequency compared to ad libitum‐feeding conditions. Stimulation of N/OFQARC neurones more robustly inhibited POMCARC neurones under fasting conditions compared to ad libitum‐feeding conditions. N/OFQARC inhibition of POMCARC neurones is hormone dependent as chemostimulation of N/OFQARC neurones from fasted males and OVX females produced a sizable outward current in POMCARC neurones. Oestradiol (E2) markedly attenuated the N/OFQ‐induced POMCARC outward current. Additionally, N/OFQ tonically inhibits POMCARC neurones to a greater degree under fasting conditions than in ad libitum‐feeding conditions as evidenced by the abrogation of N/OFQ–nociceptin opioid peptide (NOP) receptor signalling and inhibition of N/OFQ release via chemoinhibition of N/OFQARC neurones. Intra‐arcuate nucleus application of N/OFQ further elevated the hyperphagic response and increased meal size during the 6 h re‐feed period, and these effects were mimicked by chemostimulation of N/OFQARC neurones in vivo. E2 attenuated the robust N/OFQ‐induced rebound hyperphagia seen in vehicle‐treated OVX females. These data demonstrate that N/OFQARC neurones play a vital role in mitigating the impact of negative energy balance by inhibiting the excitability of anorexigenic neural substrates, an effect that is diminished by E2 in females.

image

Key points

Nociceptin/orphanin FQ (N/OFQ) promotes increased energy intake and decreased energy expenditure under conditions of positive energy balance in a sex‐ and hormone‐dependent manner.

Here it is shown that under conditions of negative energy balance, i.e. fasting, N/OFQ inhibits anorexigenic proopiomelanocortin (POMC) neurones to a greater degree compared to homeostatic conditions due to fasting‐induced hyperexcitability of N/OFQ neurones.

Additionally, N/OFQ promotes a sustained increase in rebound hyperphagia and increase in meal size during the re‐feed period following a fast.

These results promote greater understanding of how energy balance influences the anorexigenic circuitry of the hypothalamus, and aid in understanding the neurophysiological pathways implicated in eating disorders promoting cachexia.
Influence of Slip and Orientation on Entropy Generation Due to Natural Convection in a Square Cavity
Authors: Murali Damu , Suresh Kartik , C. K. Arjun , Kumar S. Ajith
Published: October 2022

Numerical simulations are performed to deduce the effects of slip wall and orientation on entropy generation due to natural convection (NC) in a square cavity for Rayleigh number (Ra) = 105. The laterally insulated square cavity, heated at the bottom wall and cooled at the top wall, is subjected to various orientation angles (ϕ) and slip velocities characterized by the Knudsen number (Kn). The two components of entropy generation, i.e., entropy generation due to heat transfer (SΘ) and entropy generation due to fluid friction (SΨ), are separately investigated by varying the orientation from 0 deg to 120 deg in steps of 15 deg and Knudsen number from 0 (no-slip) to 1.5 in steps of 0.5. Evidence indicates that, for most cases considered, entropy generation due to fluid friction (SΨ) dominates the one due to heat transfer (SΘ). It is observed that the slip velocity on the isothermal walls (us,iso) has a strong influence on SΘ whereas the variations in SΨ are closely connected to the change in the rate of shear strain. Interestingly, the presence of corner vortices and the secondary circulations near the core of the cavity are also found to affect the variation in entropy generation. The existence of active zones of SΘ in the vicinity of isothermal walls and their elongation and migration while changing the orientation is another unique characteristic noticed in this study. A new parameter called maximum velocity ratio (MVR) is also proposed to highlight the variation in velocity components within the enclosure.
Wheelchair Basketball Athletes’ Perceptions of the Coach–Athlete Relationship
Authors: Pomerleau-Fontaine Lara , Bloom Gordon A. , Alexander Danielle
Published: October 2022

The majority of research on the coach–athlete relationship has been explored from the perspective of able-bodied athletes. The purpose of this study was to explore wheelchair basketball athletes’ perceptions of the coach–athlete relationship. Timelining and semistructured interviews were conducted with six wheelchair basketball athletes, and data were analyzed using a reflexive thematic analysis. Athletes highlighted the important role that parasport coaches played in fostering an enjoyable wheelchair basketball environment and valued coaches who displayed expertise regarding their athletes’ equipment and had personal parasport athletic experiences. Additionally, athletes identified personal preferences, including coaches who addressed sex differences and maintained professional relationships at the national level as contributing factors to the coach–athlete relationship. The current results benefit both parasport coaches and athletes by providing a portrayal of coaching behaviors, characteristics, and expertise that not only influence the parasport coach–athlete dyad but also affect the well-being and athletic development of parasport athletes.
More Physical Activity Is Correlated With Reduction in Kinesiophobia for Adolescents With Persistent Symptoms After Concussion
Authors: Smulligan Katherine L. , Wingerson Mathew J. , Seehusen Corrine N. , Little Casey C. , Wilson Julie C. , Howell David R.
Published: October 2022

Context: The relationship between physical activity (PA) and fear of pain with movement (ie, kinesiophobia) during concussion recovery is unknown. Kinesiophobia may limit PA, while PA after concussion may reduce kinesiophobia. Our purpose was to examine the correlation between PA and self-reported kinesiophobia during concussion recovery for adolescents with and without persistent symptoms. Design: Prospective cohort study of children ages 10–18 years within 14 days of concussion. Methods: Participants rated kinesiophobia using the Tampa Scale of Kinesiophobia (TSK) at initial (≤14 d postconcussion) and return to play (RTP) assessments, and wore activity monitors between assessments. Our primary outcome was TSK score change from initial to RTP assessments. We grouped participants based on whether they experienced persistent symptoms (symptoms ≥28 days) or not (symptoms <28 days) and calculated correlation coefficients (Pearson r for normally distributed and Spearman rho for nonnormally distributed variables) between PA variables and TSK change scores. Results: Among the 41 participants enrolled, 44% developed persistent symptoms (n = 18; age = 14.5 [2.0] y; 50% female; symptom duration = 57.3 [6.2] d; RTP = 66.8 [6.4] d) and 56% did not (n = 23; age = 14.9 [1.8] y; 48% female; symptom duration = 15.2 [1.5] d; RTP = 21.7 [1.9] d). For the persistent symptoms group, greater TSK change scores (mean = −2.5 [5.7] point change) were significantly and moderately correlated with higher daily step count (r = −.60, P = .008) and exercise frequency (r = −.63, P = .005), but were not correlated with exercise duration (ρ = −.12, P = .65). Among the no persistent symptoms group, TSK change scores (mean = −6.0 [5.0] point change) were not correlated with step count (r = −.18, P = .41) or exercise duration (ρ = .10, P = .67), and the correlation with frequency was low and not significant (r = −.34, P = .12). Conclusions: Regular PA during concussion recovery, regardless of duration or intensity, may help reduce kinesiophobia for those experiencing persistent symptoms.
A Novel Conserved Protein in Streptococcus agalactiae, BvaP, Is Important for Vaginal Colonization and Biofilm Formation
Authors: Thomas Lamar S. , Cook Laura C.
Published: October 2022

Neonatal GBS disease is a major cause of morbidity and mortality, and maternal vaginal colonization is the leading risk factor for the disease. Colonization prevention would greatly impact the rates of disease transmission, but vaccine development has stalled as capsular polysaccharide vaccines have low immunogenicity
in vivo.
While these vaccines are still in development, the addition of a protein conjugate may prove fruitful in increasing immunogenicity and strain coverage across GBS serotypes.
Do doctors and other healthcare professionals know overdiagnosis in screening and how are they dealing with it? A protocol for a mixed methods systematic review
Authors: Piessens Veerle , Heytens Stefan , Van Den Bruel Ann , Van Hecke Ann , De Sutter An
Published: October 2022

Introduction

Overdiagnosis is the diagnosis of a disease that would never have caused any symptom or problem. It is a harmful side effect of screening and may lead to unnecessary treatment, costs and emotional drawbacks. Doctors and other healthcare professionals (HCPs) have the opportunity to mitigate these consequences, not only by informing their patients or the public but also by adjusting screening methods or even by refraining from screening. However, it is unclear to what extent HCPs are fully aware of overdiagnosis and whether it affects their screening decisions. With this systematic review, we aim to synthesise all available research about what HCPs know and think about overdiagnosis, how it affects their position on screening policy and whether they think patients and the public should be informed about it.

Methods and analysis

We will systematically search several databases (MEDLINE, Embase, Web of Science, Scopus, CINAHL and PsycArticles) for studies that directly examine HCPs' knowledge and subjective perceptions of overdiagnosis due to health screening, both qualitatively and quantitatively. We will optimise our search by scanning reference and citation lists, contacting experts in the field and hand searching abstracts from the annual conference on 'Preventing Overdiagnosis'. After selection and quality appraisal, we will analyse qualitative and quantitative findings separately in a segregated design for mixed-method reviews. The data will be examined and presented descriptively. If the retrieved studies allow it, we will review them from a constructivist perspective through a critical interpretive synthesis.

Ethics and dissemination

For this type of research, no ethical approval is required. Findings from this systematic review will be published in a peer-reviewed journal and presented at the annual congress of 'Preventing Overdiagnosis'. In addition, the results will serve as guidance for further research on this topic.

PROSPERO registration number

CRD42021244513.
Hydrodynamic representation and energy balance for Dirac and Weyl fermions in curved space-times
Authors: Matos Tonatiuh , Gallegos Omar , Chavanis Pierre-Henri
Published: October 2022

Using a generalized Madelung transformation, we derive the hydrodynamic representation of the Dirac equation in arbitrary curved space-times coupled to an electromagnetic field. We obtain Dirac–Euler equations for fermions involving a continuity equation and a first integral of the Bernoulli equation. Comparing between the Dirac and Klein–Gordon equations we obtain the balance equation for fermion particles. We also use the correspondence between fermions and bosons to derive the hydrodynamic representation of the Weyl equation which is a chiral form of the Dirac equation.
Values-Based Mathematics Teaching: Promoting Mathematical Performance, Competencies and Wellbeing
Authors: Seah Wee Tiong
Published: October 2022

Innovative practices in mathematics pedagogy at all levels of schooling are needed to better prepare our students to thrive amidst the demands of living in the 21st century, given that in many jurisdictions mathematics performance has been flat and students’ attitude toward mathematics has dipped. Beyond cognitive knowledge and skills, and beyond affective factors, the motivational aspect (and values in particular) is just as important too. Drawing on some recent relevant research findings, this paper presents what values associated with effective mathematics learning and with positive mathematical wellbeing look like. The need for teachers to be more aware and more confident of their values espousal is emphasized. Research on the JEDI approach to values learning is presented. Recent research on teacher strategies at orchestrating values alignment in their mathematics classroom is also reported.
Architecture, Protocols, and Security in IoV: Taxonomy, Analysis, Challenges, and Solutions
Authors: Karim Sulaiman M. , Habbal Adib , Chaudhry Shehzad Ashraf , Irshad Azeem
Published: October 2022

Internet of Vehicles (IoV) is a multinode network that exchanges information in an open, wireless environment. Various communication activities exist between IoV entities to share important information such as (ID, location, speed, messages, and traffic information), necessary for network operation. As part of intelligent transportation, IoV is considered a hot subject for researchers, because it is still facing many unresolved challenges, especially those concerning security and privacy. The variation of security-privacy threats that can menace the safety, privacy, and lives of vehicle occupants makes security the leading point of interest. The development of communication protocols for autonomous vehicles opens to us new issues to study and enhance the performance of IoV networks in terms of security and privacy. Several works have been reported, proposing many solutions for practical security challenges including a considerable number of survey-review papers published in respectable channels. The main motive of this review paper is to present the latest developments related to IoV security, as well as to address existing limitations. The high frequency of publication on IoV architecture, security, and new solutions leads us to write a compact, comprehensive, and up-to-date review. Inclusion criteria for selected papers include recent publications, number of citations, and impact of the research. In the present survey paper, the IoV architecture model is defined with all related communication types, and security and privacy issues are analyzed and presented with recently proposed solutions in a clear method. Clear classifications of threats, attacks, protocols, and solutions are presented. Moreover, the use of blockchain-based IoV to improve system security is discussed highlighting the most important trends and taxonomies. The paper was written to be a candidate as the first to read on the topic of the IoV security challenge, presenting problems and solutions in a clear, smooth, complete, and integrated manner.
Design of Precise Estimation Algorithm for Sports Pose Based on Multifeature Fusion
Authors: Songai Gao , Ningning Zhang , Xiang Zheng
Published: October 2022

The estimation time and estimation precision of motion pose samples are problematic for the pose estimation algorithm of sports movements. This paper proposes a multifeature fusion-based algorithm for accurate posture estimation. The human rod model is constructed after analyzing the human pose estimation technology. Using the Kalman filter method, the degree of freedom and range of motion of the major joints of the human body were determined. The eight-star model was used to extract the sports posture features, and the weighted average method was used to process the grayscale images of sports. Using the multifeature fusion method, the extracted multisource feature vector information is thoroughly analyzed and processed, and a new group of fusion feature vectors is created. Using a mixture Gaussian distribution model, the posture estimation of an athlete’s body is accomplished. Experimental results indicate that when the amount of sports pose sample data is 900 GB, the accurate estimation time of the proposed method is 5.3 s, and its accuracy is 100 percent. Improve the estimation accuracy of samples of sports posture.
The Future Development Direction of Cloud-Associated Edge-Computing Security in the Era of 5G as Edge Intelligence
Authors: Devi Odugu Rama , Webber Julian , Mehbodniya Abolfazl , Chaitanya Morsa , Jawarkar Parag S. , Soni Mukesh , Miah Shahajan
Published: October 2022

By introducing the Internet-of-Everything, new usage situations such as self-directed movement and vivid competitions constructed upon Virtual Reality or Augmented Reality expertise, besides the Industrial-Internet-of-Thing, accelerates the initial growth of edge-registering improvements. The global versatile correspondence business is now developing toward 5G. Edge processing has gotten a lot of attention around the globe as 5G is one of the major access enhancements to advance the huge scope organization of edge registration. Edge processing security has been a significant area of concern since the advent of edge registers, limiting its execution and enhancement. Edge figuring security has been greatly hampered by the innovative structures of edge-registering, the reconciliation with a huge number of innovations, the innovative usage conditions carried on through edge-processing, and common growing requirements aimed at safety insurance. This report examines the ebb and flow of examination anxiously registering security research. This article highlights the security issues of edge processing from five perspectives, including network access, key administration, protection assurance, assault mitigation, and irregularity identification, by breaking down the safety tests among edge-registering cutting-edge terms of innovative representations, and novel applications situations, as well as innovation conditions. The study separately discusses the scholastic community’s exploratory accomplishments among the applied domains, as well as the compensations for the drawbacks. In conclusion, the upcoming expansion track toward edge-computing safety has been conferred as well as projected, combining edge-cloud coordinated effort and edge intelligence.
HDAC2 Induces DNA Methyltransferase DNMT3B Expression to Regulate the Wnt Signaling Pathway and Thus Promotes Glioma Development and Progression
Authors: Ren Xing , Jiang Zhan , Xu Ke
Published: October 2022

Purpose. To investigate the role and molecular mechanism of HDAC2 in glioma. Methods. GSE16011, GSE31262, and GSE90598 datasets were used to identify co-expressed genes, GO analysis, and KEGG analysis to identify gene enrichment pathways, and PPI networks were constructed to identify gene interrelationships. HDAC2 enrichment on DNMT3B promoter and DNMT3B enrichment on Bcl2 CpG island was detected by a ChIP assay. The expression, prognosis, and hierarchical distribution of HDAC2, DNMT3B, and Bcl2 were examined in the CGGA database, and the correlation between HDAC2 and DNMT3B, Bcl2, and DNMT3B and Bcl2 was assessed. Results. The HDAC2-DNMT3B-Bcl2 axis is differentially expressed and interacts in gliomas. HDAC2 activates the transcriptional activity of DNMT3B, and DNMT3B inhibits the expression of Bcl2. HDAC2 and DNMT3B are highly expressed in gliomas and have a poor prognosis, while Bcl2 is lowly expressed in gliomas and has a good prognosis. Conclusion. HDAC2 promotes DNMT3B transcriptional repression of Bcl2 expression and Wnt pathway activity, thereby activating glioma cell activity in vitro and in vivo.
Identification and Functional Characterization of a Novel Variant in the SEMA3A Gene in a Chinese Family with Kallmann Syndrome
Authors: Shu Meng , Wu Huixiao , Wei Shuoshuo , Shi Yingzhou , Li Zongyue , Cheng Yiping , Fang Li , Xu Chao
Published: October 2022

Background. Kallmann syndrome (KS) is a rare genetic disease characterized by the reproductive system and olfactory dysplasia due to the defective migration of gonadotropin-releasing hormone (GnRH) neurons. However, this disorder is clinically heterogeneous and the genotype-phenotype relationship has not been determined. Objective. The present study aimed to identify the variant causing KS in a Chinese family and evaluate the functional consequences and phenotypes associated with the novel variant. Methods. A Chinese family with KS was screened for pathogenic variants by whole-exome sequencing (WES). Bioinformatic analysis was performed to predict the consequences of the identified variant. The expression of the mutant protein was examined in vitro. Results. A novel heterozygous variant (NM_006080.2 : c.814G > T) in SEMA3A was identified in the patient and his father, which caused the substitution of aspartic acid with tyrosine in codon 272. It was predicted to result in pathogenic significance with a high damaging score and seriously affect protein structure by bioinformatic analysis. In vitro experiments revealed this variant could significantly decrease the expression of SEMA3A. Furthermore, it may cause the disease by failing to induce the phosphorylation of focal adhesion kinase (FAK) in GnRH neurons. Conclusion. Identification and functional characterization of this novel variant in the SEMA3A gene in a Chinese family with Kallmann syndrome extend the genetic variant spectrum of SEMA3A and provide more data about the heterogeneity of KS, which may provide further insights into the diagnosis of KS and help patients get additional data in genetic counseling and timely treatment.
Glutamine Transporter SLC1A5 Regulates Ionizing Radiation-Derived Oxidative Damage and Ferroptosis
Authors: Yuan Zhuhui , Liu Tong , Huo Xiao , Wang Hao , Wang Junjie , Xue Lixiang
Published: October 2022

Ionizing radiation-derived oxidative stress and ferroptosis are one of the most important biological effects on destroying the liver tumor, whereas radioresistance of liver tumor remains a leading cause of radiotherapy (RT) failure mainly because of the protective antiferroptosis, in which oxidative stress and subsequent lipid peroxidation are the key initiators. Thus, it is of great importance to overcome ferroptosis resistance to improve the therapeutic efficacy of RT in liver tumor patients. Irradiation-resistant HepG2 cells (HepG2-IRR) were established by long-term exposure to X-ray (2 to 8 Gy), and targeted metabolomics analysis revealed an obvious increase in intracellular amino acids in HepG2-IRR cells upon ferroptosis stress. Among these amino acids with obvious changes, N-acetylglutamine, a derivative of glutamine, is essential for the redox homeostasis and progression of tumor cells. Interestingly, the treatment of glutamine starvation could promote the ferroptosis effect significantly, whereas glutamine supplementation reversed the ferroptosis effect completely. Consistent with the changes in amino acids pattern, the glutamine transporter SLC1A5 was verified in liver tumor samples from TCGA training and validation cohorts as an independent prognostic amino acid-ferroptosis gene (AFG). A risk score for screening prognosis based on the SLC1A5, SLC7A11, ASNS, and TXNRD1 demonstrated that a high-risk score was correlated with poor survival. In vitro studies had shown that the knockdown of SLC1A5 resulted in a significant decrease in cell viability and promoted lipid peroxidation and oxidative damage introduced by irradiation (10 Gy). Collectively, our findings indicated that SLC1A5 may act as a suppressor gene against ferroptosis and can be a potential target for ionizing radiation mediated effects.
Eucommia ulmoides Oliver’s Multitarget Mechanism for Treatment of Ankylosing Spondylitis: A Study Based on Network Pharmacology and Molecular Docking
Authors: Zhang Hong-Sheng , Zhang Sheng-Nan , Guo Wei-Kun , He Sheng-Hua
Published: October 2022

Background. Eucommia ulmoides Oliver (EU) is a plant used in Chinese medicine as a medicinal herb to treat autoimmune and inflammatory conditions. We used network pharmacology to examine the active ingredients and estimate the main targets and pathways affected by EU when it is used to treat ankylosing spondylitis (AS). Materials and Methods. The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to search for active ingredients in EU and their target proteins. The GeneCards Database was used to find AS-related targets. The targets from the EU and AS searches that coincided were selected by constructing a Venn diagram. Then, a STRING network platform and Cytoscape software were used to analyse the protein-protein interaction (PPI) network and key targets. The strong affinity between EU and its targets was confirmed using molecular docking techniques. The Gene Ontology and the Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis of overlapping targets was performed using the database for annotation, visualization, and integrated discovery online tool. Results. The number of active ingredients against AS in EU was discovered to be 28. Major targets against AS in the PPI network and core targets analyses were identified as IL-1B, PTGS2, IL-8, nMMP-9, CCL2, MYC, and IL-2. Furthermore, molecular docking studies showed the strong affinity between EU’s bioactive molecules and their AS targets. Enrichment analysis revealed that active ingredients from EU were involved in a variety of biological processes, including the response to molecules derived from bacteria, extracellular stimuli, nutrient levels, and the regulation of reactive oxygen species, all of which are mediated by interleukin-17, TNF-α, and other signalling pathways. Conclusion. The therapy for AS using EU involves a multitarget, multipathway, and multiselection mechanism that includes anti-inflammatory and analgesic effects. This study provides a theoretical basis for future research into targeted molecular therapies for AS.
Application of Intelligent Sensor Network in the Assessment of Table Tennis Teaching and Training Intensity, Training Volume, and Physical Fitness
Authors: Zhang Hao
Published: October 2022

Sensor technology has been deeply into the sports industry, with the help of sensors to monitoring and collection data for the physical training in real-time. In table tennis, wearable sensors can record the amount of training, movement essentials, and the number of strokes of both hands and assist in the testing and evaluation of table tennis. This paper analyzes the application of wearable sensors in table tennis training activities and the details of signal collection and feature extraction. At the same time, machine learning technology often used to recognize and test table tennis training data, and a support vector machine (SVM) is one of the representative classifiers. Applying the processed signal data to the classification and testing of SVM can effectively identify the movement and evaluate the training effect and athletes’ physical fitness. The integration of intelligent sensors and table tennis can effectively improve the evaluation efficiency and quality in the process of teaching and training.
[Retracted] Effect of Vegetable Waste on Growth Performance and Hematology of Broiler Chicks
Authors: Nisar Muhammad Shahid , Zahra Anjum , Iqbal Muhammad Fahad , Bashir Muhammad Amjad , Yasin Riffat , Samiullah Khizar , Aziz Irum , Saeed Sidra , Alasmari Abdulrahman , Elsaid Fahmy G. , Shati Ali A. , Al-Kahtani Mohammed A. , Naseem Farwa , Fatima Maryam , Ahmed Faraz
Published: October 2022

Vegetable waste (spinach, potato, and cauliflower) is a rich and natural source of nutrients, potentially good for supplying minerals, essential amino acids, and antioxidants to the birds. Relatively, its cost very low, easily to accessible, easily process & pose little risk of illness. The aim of present study was to evaluate the effect of vegetable waste (VW) as feed supplement on growth performance and hematology of broiler chicks. For this purpose, a total of 200 (4 days old) vaccinated chicks were acquired from a commercial hatchery Multan which was acclimated for three weeks (21 days) on basal starter feed after that 25‐day‐old chicks with uniform body weight were allocated according to a CRD (completely randomized design) into four dietary treatments with three replicates of each contained 15 chicks in 12 pens. In dietary treatments, chicks were feed with basal feed (BF) and supplemented feed with vegetable waste (VW) of spinach, potato, and cauliflower. For this purpose, the dietary treatments included control treatment (T1) (100% BF+0% VW) and other dietary treatments (T2) (75% BF+25% VW), (T3) (50% BF+50% VW), and (T4) (25% BF+75% VW). The body weight, feed intake, food conversion ratio (FCR), and mortality were checked on weekly and daily basis. For hematology analysis, after the 1st experimental week (25‐day‐old chicks) and the last 5th experimental week (56‐day‐old chicks), the samples of blood were gathered from the wing’s veins of two birds from each treatment in random way. At the end of five weeks (35 days), birds with uniform average body weight were selected per treatment with three replicates (2 bird/replicate) and then were manually slaughtered according to the Halal method to analyze the weight of internal body organs of broilers by physical and statistical analysis (ANOVA). There was no significant effect (P > 0.05) on feed intake and FCR among all the dietary treatments. But in average, body weight and BWG were higher in treatment (T2) (P < 0.01) than all other dietary treatments (T3) and (T4) and control treatment (T1). The blood constituents in this study showed that broilers in control treatment (T1) and other dietary treatments (T2), (T3), and (T4) fed on different doses were significantly (P < 0.01) different from each other. The week 5 (W5) shows higher values of blood constituents (P < 0.01) than week 1 (W1). The carcass yield of the chicks fed on different doses showed that they were significantly different (P < 0.01) among the dietary treatments. The VW inclusion 0%, 25%, 50%, and 75% had positive effect on blood constituents and carcass yield of the broiler chicks; they were significantly (P < 0.01) different among the treatments.
MiR-19b-3p Attenuates Chondrocytes Injury by Inhibiting MAPK/NF-Κb Axis via Targeting SOCS1
Authors: Shi Liang , Duan Liang , Duan Dapeng , Fan Yayi , Xu Honghai
Published: October 2022

In this study, miR-19b-3p was downregulated in osteoarthritic cartilage tissues and IL-1β-stimulated primary chondrocytes, and miR-19b-3p overexpression reversed the inhibitory effect of IL-1β on cell viability, the promotion effects of apoptosis, inflammatory factor secretion and extracellular matrix degradation, whereas the opposite effect was observed with miR-19b-3p inhibitor. Moreover, SOCS1 is a target gene of miR-19b-3p. Furthermore, SOCS1 overexpression enhanced cell injury compared with IL-1β alone treatment, whereas knockdown of SOCS1 restored cell damage caused by IL-1β. Further studies revealed that miR-19b-3p promoted chondrocyte injury repair by suppressing SOCS1 expression, and we found that was mediated by blocking the MAPK/NF-κB axis. Taken together, our findings may provide a new therapeutic strategy for osteoarthritis.
[Retracted] A Metadecomposition of Clinical Value Assessed Using aEEG in Severe Neonatal Hyperbilirubinemia
Authors: Chen Zhong , He Qi , Li Wenxing , Liang Juan , Zhu Tingting , Tang Jun
Published: October 2022

Amplitude‐integrated electroencephalography (aEEG) is an effective and simple means of continuous EEG monitoring beside the neonatal bed, which can be used to predict the early brain injury and prognosis evaluation of neonatal hyperbilirubinemia. This paper summarized 11 randomized controlled studies to meta‐analyze the value of aEEG in evaluating neonatal hyperbilirubinemia and acute bilirubin encephalopathy. Through the literature search of health and interest science engineering and computer in the medical databases such as Wanfang Medicine and PubMed database, the medical information literature of aEEG to evaluate the clinical value in neonatal severe hyperbilirubinemia is used, and RevMan 5.2 software is selected for metadecomposition. The experimental results show that their serum total bilirubin is significantly higher than that of normal newborns, and with the aggravation of the condition, the serum expression is higher and higher. aEEG can effectively enhance the detection rate of such sufferers and help sufferers to receive therapy as soon as possible to ensure the prognosis of children.
Metacognitive Strategies in Undergraduate College Students’ English Writing Based on Optimization Theory
Authors: Liang Ting
Published: October 2022

In the existing research, scholars have different views on the concept and structure of metacognition. Based on different theories, they produce different training methods of metacognition strategies. However, because the training design and training process in the experiment are too complicated and the time is difficult to control, it remains difficult to effectively extend this kind of training to more educational fields. This paper deeply integrates the optimization theory with the case teaching of college students’ English writing in undergraduate colleges and proposes the optimal design of the case teaching process. The optimal design is mainly carried out according to four processes: English writing education consultation, English writing teaching case compilation, English writing case teaching implementation, and English writing case teaching evaluation. In ordinary English writing, students focus on four aspects: preplanning, selective attention, self-monitoring, self-evaluation, and adjusting, controlling, and managing one's own cognitive activities according to self-monitoring metacognitive strategies, mastering the optimization theory, and adjusting the writing speed are self-adjustment and self-evaluation according to one's own situation. In the selected dimensions of English writing, the mean of the postwriting test was higher than that of the prewriting test. The mean of the “average sentence length” increased from 8.6 to 19.1. Integrating metacognitive strategy training into English writing teaching can improve students’ English writing ability.
Automatic Detection and Segmentation of Ovarian Cancer Using a Multitask Model in Pelvic CT Images
Authors: Wang Xun , Li Hanlin , Zheng Pan
Published: October 2022

Ovarian cancer is one of the most common malignant tumours of female reproductive organs in the world. The pelvic CT scan is a common examination method used for the screening of ovarian cancer, which shows the advantages in safety, efficiency, and providing high-resolution images. Recently, deep learning applications in medical imaging attract more and more attention in the research field of tumour diagnostics. However, due to the limited number of relevant datasets and reliable deep learning models, it remains a challenging problem to detect ovarian tumours on CT images. In this work, we first collected CT images of 223 ovarian cancer patients in the Affiliated Hospital of Qingdao University. A new end-to-end network based on YOLOv5 is proposed, namely, YOLO-OCv2 (ovarian cancer). We improved the previous work YOLO-OC firstly, including balanced mosaic data enhancement and decoupled detection head. Then, based on the detection model, a multitask model is proposed, which can simultaneously complete the detection and segmentation tasks.
New Power System Based on Renewable Energy in the Context of Dual Carbon
Authors: Ning Liang , Yuan Tianmeng , Wu Haotian
Published: October 2022

Energy is the basic driving force to promote the economic development of all countries in the world. In the face of the era of great changes unseen in a century, the world is actively deploying and developing renewable energy. However, these forms of new energy power generation are characterized by intermittency and randomness, and their unstable power characteristics and uncontrollable source capacity have negative consequences for the secure and stable operation of the electricity system. Therefore, once new energy sources are incorporated on a large scale, system reliability studies are required. The mission of the new electricity system with new resources as the main source is to adapt to the development of large-scale renewable energy and solve the three major problems of shortage of existing energy and power, pollution, and safety. In comparison to conventional electrical systems, the new power system is not a simple replacement but a revolution. Therefore, this paper studied a new type of power system based on renewable energy. Through experiments, it is concluded that the new electricity system with renewable energy sources is not only more environmentally friendly but also can save 10.5% of electricity costs and greatly improve the utilization rate of available energy.
Psychological Distress among Healthcare Workers with Chronic Diseases during the COVID-19 Crisis
Authors: Alfaraj Huriyyah Abdullah , Alsharif Fatmah Hazza , Elhady Mona Mohamed
Published: October 2022

Background. Healthcare workers (HCWs) are a vulnerable group to psychological distress (PD) because they are subjected to strict working conditions, and the nature of the work implies a heavy level of emotional involvement. Objective. This study is aimed at determining psychological distress among healthcare workers with chronic diseases during the COVID-19 crisis. Methods. This was a quantitative cross-sectional correlation study. An online self-administered questionnaire was completed from July 2021 to October 2021 by a convenience sample of 302 HCWs at two primary healthcare centers in Saudi Arabia. The Kessler psychological distress scale was used to assess psychological distress among HCWs. Results. The prevalence of HCWs who contracted COVID-19 was 59.9%. The overall mean score of K10 was 4.38 (

SD
=
0.706

). The majority of HCWs that had the highest percentage of a very high level of distress were female (66.2%), between the ages of 30 and 40 years (35.1%), had more than 10 years of work experience (48.0%), and were nurses (49.7%), married (61.6%), and infected with COVID-19 (59.9%). There was a significant association between the age, working experience, and PD scores of the HCWs

P

value < 0.05. A significant correlation between each of the variables of (heart disease, high blood pressure, lung disease, diabetes, ulcer, anemia, depression, and back pain) and PD whereas the

P

value < 0.05 and the

R

value < 0.3. Conclusion. HCWs with associated comorbidities have been greatly affected by the COVID-19 pandemic. There was a very high level of PD among the studied population. HCWs with hypertension and back pain were the most affected by psychological distress, and emotional distress could be exacerbated if the HCWs contracted COVID-19.
Comprehensive Analysis of GDF10 Methylation Site-Associated Genes as Prognostic Markers for Endometrial Cancer
Authors: Fan Jingyi , Zhou Huaijun
Published: October 2022

Growth differentiation factor-10 (GDF10) with its methylation trait has recently been found to play a crucial regulatory and communication role in cancers. This investigation aims to identify GDF10 methylation site-associated genes that are closely associated with endometrial cancer (EC) patients’ survival based on normal and UCEC samples from the UCSC Xena database. Our study revealed for the first time that EC exhibited significantly higher levels of GDF10 promoter methylation in comparison with normal tissues. Multiple differentiated methylation sites, which have prognostic value due to their apparent survival differences, were found in the GDF10 promoter region. We performed weighted gene coexpression network analysis (WGCNA) on EC tissues and paraneoplastic tissues while using these differentially methylated sites as phenotypes for selecting the most correlated key modules and their internal genes. To obtain a gene set, the key module genes and differentially expressed genes (DEGs) of EC were intersected. The least absolute shrinkage and selection operator (LASSO) regression along with multivariate Cox regression were performed from the gene set and we screened out the key genes B4GALNT3, DNAJC22, and GREB1. Finally, a prognostic model was validated for effectiveness based on these genes. Additionally, Kaplan-Meier analysis and time-dependent receiver operating characteristics (ROC) were applied to assess and verify the model, and they showed good prognosis prediction. Moreover, the differences in risk scores were statistically significant with age, tumor stage, and grade. They may be related to the immune infiltration of tumors as well. In conclusion, based on the methylation-related genes associated with GDF10, we developed a prognosis model for EC patients. It might provide a fresh view for further research and treatment of EC.
Comparison of Bayesian and Classical Methods for Exploring the Important Factors regarding Maternal and Child Health Care
Authors: Alshenawy R. , Feroze Navid , Almuhayfith Fatimah Essa , Al-Alwan Ali A. , Nazakat Aneela , Hossain Md. Moyazzem
Published: October 2022

The literature contains a number of studies to analyze the important factors relating to maternal and child health care (MCH). However, the earlier contributions have employed classical models for the analysis. We have proposed Bayesian models for exploring the factors regarding MCH in Pakistan. The latest data, from Pakistan Demographic and Heath Survey (PDHS) conducted in 2017-18, have been used for analysis. The performance of Bayesian methods have been compared with classical methods based on various goodness-of-fit criteria. The performance of Bayesian methods was observed to be better than the classical methods. The results advocated that 86.20% of mothers received antenatal care (ANC), while only 51.40% of the mothers received it at least for ANC visits during the whole pregnancy period. Further, 68.90% of the mothers were protected against neonatal tetanus. More than 30% of women neither delivered in the health facility place nor they were in receipt of postnatal checkups. Additionally, only three out of five newborns were availed with postnatal checkup (PNC) within two days of their births. About 66.89% of women reported problems in accessing the MCH in the country. The study also suggested the presence of severe disparities among different socio-economic groups in availing MCH. There is immediate need to reduce these disparities among various socio-economic groups in the country.
The Application of Modern Computer-Aided Technology in Fine Art Education
Authors: Wang Baoqi
Published: October 2022

With the popularization of modern computer technology, human society has stepped into the information age. Modern computer technology will have an all-round and deep impact on fine art education in China. In fine art education, various information devices play an important role in broadening the resources of fine art education and effectively improving the quality of fine art education. This study analyzes fine art education in the digital era and studies how the quality of fine art education can be improved through computer-aided technology.