bluuebunny/crossref_metadata_2025 huggingface dataset:
How do we best engage young people in decision-making about their health? A scoping review of deliberative priority setting methods
Authors: Watson Daniella , Mhlaba Mimi , Molelekeng Gontse , Chauke Thulani Andrew , Simao Sara Correia , Jenner Sarah , Ware Lisa J. , Barker Mary
Published: January 2023

Introduction

International organisations have called to increase young people’s involvement in healthcare and health policy development. We currently lack effective methods for facilitating meaningful engagement by young people in health-related decision-making. The purpose of this scoping review is to identify deliberative priority setting methods and explore the effectiveness of these in engaging young people in healthcare and health policy decision-making.

Methods

Seven databases were searched systematically, using MeSH and free text terms, for articles published in English before July 2021 that described the use of deliberative priority setting methods for health decision-making with young people. All titles, abstracts and full-text papers were screened by a team of six independent reviewers between them. Data extraction followed the Centre for Reviews and Dissemination guidelines. The results are presented as a narrative synthesis, structured around four components for evaluating deliberative processes: 1) representation and inclusion of diverse participants, 2) the way the process is run including levels and timing of participant engagement, 3) the quality of the information provided to participants and 4) resulting outcomes and decisions.

Findings

The search yielded 9 reviews and 21 studies. The more engaging deliberative priority setting tools involved young people-led committees, mixed methods for identifying and prioritising issues and digital data collection and communication tools. Long-term and frequent contact with young people to build trust underpinned the success of some of the tools, as did offering incentives for taking part and skills development using creative methods. The review also suggests that successful priority setting processes with young people involve consideration of power dynamics, since young people’s decisions are likely to be made together with family members, health professionals and academics.

Discussion

Young people’s engagement in decision-making about their health is best achieved through investing time in building strong relationships and ensuring young people are appropriately rewarded for their time and contribution. If young people are to be instrumental in improving their health and architects of their own futures, decision-making processes need to respect young people’s autonomy and agency. Our review suggests that methods of power-sharing with young people do exist but that they have yet to be adopted by organisations and global institutions setting global health policy.
Risk of longer-term neurological conditions in the Deepwater Horizon Oil Spill Coast Guard Cohort Study – Five years of follow-up
Authors: Denic-Roberts Hristina , Engel Lawrence S. , Buchanich Jeanine M. , Miller Rachel G. , Talbott Evelyn O. , Thomas Dana L. , Cook Glen A. , Costacou Tina , Rusiecki Jennifer A.
Published: January 2023

Background

Long-term neurological health risks associated with oil spill cleanup exposures are largely unknown. We aimed to investigate risks of longer-term neurological conditions among U.S. Coast Guard (USCG) responders to the 2010Deepwater Horizon(DWH) oil spill.

Methods

We used data from active duty members of the DWH Oil Spill Coast Guard Cohort Study (N=45224). Self-reported oil spill exposures were ascertained from post-deployment surveys. Incident neurological outcomes were classified using International Classification of Diseases, 9th Revision, codes from military health encounter records up to 5.5 years post-DWH. We used Cox Proportional Hazards regression to calculate adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for various incident neurological diagnoses (2010–2015). Oil spill responder (n=5964) vs. non-responder (n= 39260) comparisons were adjusted for age, sex, and race, while within-responder comparisons were additionally adjusted for smoking.

Results

Compared to those not responding to the spill, spill responders had reduced risks forheadache(aHR=0.84, 95% CI: 0.74-0.96),syncope and collapse(aHR=0.74, 95% CI: 0.56-0.97), anddisturbance of skin sensation(aHR=0.81, 95% CI: 0.68-0.96). Responders reporting ever (n=1068) vs. never (n=2424) crude oil inhalation exposure were at increased risk for several individual and grouped outcomes related to headaches and migraines (aHR range: 1.39-1.83). Crude oil inhalation exposure was also associated with elevated risks for an inflammatory nerve condition,mononeuritis of upper limb and mononeuritis multiplex(aHR=1.71, 95% CI: 1.04-2.83), andtinnitus(aHR=1.91, 95% CI: 1.23-2.96), a condition defined by ringing in one or both ears. Risk estimates for those neurological conditions were higher in magnitude among responders reporting exposure to both crude oil and oil dispersants than among those reporting crude oil only.

Conclusion

In this large study of active duty USCG responders to the DWH disaster, self-reported spill cleanup exposures were associated with elevated risks for longer-term neurological conditions.
Anti-inflammatory effects of β-FNA are sex-dependent in a pre-clinical model of LPS-induced inflammation
Authors: Myers Stephanie , McCracken Kelly , Buck Daniel J. , Curtis J. Thomas , Davis Randall L.
Published: January 2023

Background

Inflammation is present in neurological and peripheral disorders. Thus, targeting inflammation has emerged as a viable option for treating these disorders. Previous work indicated pretreatment with beta-funaltrexamine (β-FNA), a selective mu-opioid receptor (MOR) antagonist, inhibited inflammatory signaling in vitro in human astroglial cells, as well as lipopolysaccharide (LPS)-induced neuroinflammation and sickness-like-behavior in mice. This study explores the protective effects of β-FNA when treatment occurs 10 h after LPS administration and is the first-ever investigation of the sex-dependent effects of β-FNA on LPS-induced inflammation in the brain and peripheral tissues, including the intestines.

Results

Male and female C57BL/6J mice were administered LPS followed by treatment with β-FNA-immediately or 10 h post-LPS. Sickness- and anxiety-like behavior were assessed using an open-field test and an elevated-plus-maze test, followed by the collection of whole brain, hippocampus, prefrontal cortex, cerebellum/brain stem, plasma, spleen, liver, large intestine (colon), proximal small intestine, and distal small intestine. Levels of inflammatory chemokines/cytokines (interferon γ-induced-protein, IP-10 (CXCL10); monocyte-chemotactic-protein 1, MCP-1 (CCL2); interleukin-6, IL-6; interleukin-1β, IL-1β; and tumor necrosis factor-alpha, TNF-α) in tissues were measured using an enzyme-linked immunosorbent assay. Western blot analysis was used to assess nuclear factor-kappa B (NF-κB) expression. There were sex-dependent differences in LPS-induced inflammation across brain regions and peripheral tissues. Overall, LPS-induced CXCL10, CCL2, TNF-α, and NF-κB were most effectively downregulated by β-FNA; and β-FNA effects differed across brain regions, peripheral tissues, timing of the dose, and in some instances, in a sex-dependent manner. β-FNA reduced LPS-induced anxiety-like behavior most effectively in female mice.

Conclusion

These findings provide novel insights into the sex-dependent anti-inflammatory effects of β-FNA and advance this agent as a potential therapeutic option for reducing both neuroinflammation an intestinal inflammation.
Nipple-areolar complex (NAC) or skin flap ischemia necrosis post nipple-sparing mastectomy (NSM)—analysis of clinicopathologic factors and breast magnetic resonance imaging (MRI) features
Authors: Lai Hung-Wen , Lee Yi-Yuan , Chen Shou-Tung , Liao Chiung-Ying , Tsai Tsung-Lin , Chen Dar-Ren , Lai Yuan-Chieh , Kao Wen-Pin , Wu Wen-Pei
Published: January 2023

Background

The purpose of this study is to identify clinicopathologic factors and/or preoperative MRI vascular patterns in the prediction of ischemia necrosis of the nipple-areola complex (NAC) or skin flap post nipple-sparing mastectomy (NSM).

Methods

We performed a retrospective analysis of 441 NSM procedures from January 2011 to September 2021 from the breast cancer database at our institution. The ischemia necrosis of NAC or skin flap was evaluated in correlation with clinicopathologic factors and types of skin incision. Patients who received NSM with preoperative MRI evaluation were further evaluated for the relationship between vascular pattern and the impact on ischemia necrosis of NAC or skin flap.

Results

A total of 441 cases with NSM were enrolled in the current study, and the mean age of the cases was 49.1 ± 9.8 years old. A total of 41 (9.3%) NSM procedures were found to have NAC ischemia/necrosis. Risk factors were evaluated of which old age, large mastectomy specimen weight (> 450 g), and peri-areola incision were identified as predictors of NAC necrosis. Two-hundred seventy NSM procedures also received preoperative MRI, and the blood supply pattern was 18% single-vessel type and 82% double-vessel pattern. There were no correlations between MRI blood supply patterns or types of skin flap incisions with ischemia necrosis of NAC. There were also no correlations between blood loss and the pattern or size of the blood vessel.

Conclusion

Factors such as the type of skin incision, age, and size of mastectomy weight played an important role in determining ischemia necrosis of NAC; however, MRI vascular (single or dual vessel supply) pattern was not a significant predictive factor.
Macrophage activation syndrome in children with Kikuchi-Fujimoto disease
Authors: Shen Zixuan , Ling Jiayun , Zhu Xiaona , Yang Jun , He Tingyan
Published: January 2023

Background

Kikuchi-Fujimoto disease (KFD) is typically a benign, self-limiting inflammatory disease. However, some patients may have a prolonged or recurrent disease course, or present with life-threatening complications such as macrophage activation syndrome (MAS). In this study, we aimed to describe the incidence and clinical features of MAS in KFD and to access potential laboratory markers for the diagnosis of KFD-associated MAS.

Methods

Patients with KFD were retrospectively enrolled from January 2015 to November 2021 at Shenzhen Children’s Hospital. Clinical data were collected from inpatient or outpatient medical records. Data collected included clinical manifestations, laboratory and imaging findings, treatment, and clinical outcomes. Data were analyzed using GraphPad Prism 8.0 statistical software (GraphPad Software Inc., La Jolla, CA, USA). A receiver operating characteristic (ROC) curve analysis was further performed to access the potential predictors for the KFD-MAS diagnosis.

Results

Of 58 patients with a histological diagnosis of KFD, 15 (25.9%) patients had MAS. Compared to patients without MAS, patients with KFD-MAS presented with a higher proportion of skin rash (26.7%, p = 0.01), glucocorticoid treatment (80%, p = 0.003), and disease recurrence (33.3%, p = 0.04). KFD-MAS patients had lower absolute peripheral white blood cell (WBC, p = 0.02), platelet (p = 0.002), serum albumin levels (p = 0.01), and lymphocyte count (p < 0.0001), and higher lactate dehydrogenase (LDH) levels (p < 0.0001). ROC curve analysis showed that the cutoff values of absolute lymphocyte count, an absolute platelet count, serum albumin level, and serum LDH level for KFD-MAS diagnosis were < 1235/μL, < 171 × 106/μL, < 35.6 g/L, and > 679 IU/mL, respectively.

Conclusions

The presence of KFD-MAS in children may be more common than previously expected, especially in those with skin rash. KFD-MAS may be associated with a higher recurrence rate. An extremely elevated serum LDH level and moderate to severe lymphopenia may be useful diagnostic markers for MAS in KFD.

Trial registration

Not applicable; this was a retrospective study.
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice
Authors: Zamorano Miriam , Alexander Jenolyn F. , Catania Desiree , Dharmaraj Shruti , Kavelaars Annemieke , Heijnen Cobi J.
Published: January 2023

Background

There is increasing concern that cancer and cancer treatment accelerate aging and the associated cognitive decline. We showed recently that treatment of 9-month-old male mice with cisplatin causes cognitive deficits that are associated with formation of tau deposits in the hippocampus.

Here we explored the capacity of mesenchymal stem cells (MSC) given via the nose to prevent age-related brain tau deposits. Moreover, we more closely examined the cellular distribution of this hallmark of accelerated brain aging in response to treatment of 9-month-old female and male mice with cisplatin.

Results

We show that cisplatin induces tau deposits in the entorhinal cortex and hippocampus in both sexes. The tau deposits colocalize with syndecan-2. Astrocytes surrounding tau deposits have increased glial fibrillary acidic protein glial fibrillary acidic protein (GFAP) expression. Most of the cisplatin-induced tau deposits were located in microtubule associated protein-2 (MAP-2)+neurons that were surrounded by aquaporin 4+(AQP4)+neuron-facing membrane domains of astrocytes. In addition, some tau deposits were detected in the perinuclear region of GFAP+astrocytes and in CD31+endothelial cells. There were no morphological signs of activation of ionized calcium binding adaptor molecule-1+(Iba-1)+microglia and no increases in brain cytokine production.

Nasal administration of MSC at 48 and 96 hours after cisplatin prevented formation of tau deposits and normalized syndecan-2 and GFAP expression. Behaviorally, cisplatin-induced tau cluster formation was associated with reduced executive functioning and working/spatial memory and nasal administration of MSC at 48 and 96 hours after cisplatin prevented these cognitive deficits. Notably, delayed MSC administration (1 month after cisplatin) also prevented tau cluster formation and cognitive deficits, in both sexes.

Conclusion

In summary, nasal administration of MSC to older mice at 2 days or 1 month after completion of cisplatin treatment prevents the accelerated development of tau deposits in entorhinal cortex and hippocampus and the associated cognitive deficits. Since MSC are already in clinical use for many other clinical indications, developing nasal MSC administration for treatment of accelerated brain aging and cognitive deficits in cancer survivors should be feasible and would greatly improve their quality of life.
Optimal guidance whale optimization algorithm and hybrid deep learning networks for land use land cover classification
Authors: Vinaykumar V. N. , Babu J. Ananda , Frnda Jaroslav
Published: January 2023

Satellite Image classification provides information about land use land cover (LULC) and this is required in many applications such as Urban planning and environmental monitoring. Recently, deep learning techniques were applied for satellite image classification and achieved higher efficiency. The existing techniques in satellite image classification have limitations of overfitting problems due to the convolutional neural network (CNN) model generating more features. This research proposes the optimal guidance-whale optimization algorithm (OG-WOA) technique to select the relevant features and reduce the overfitting problem. The optimal guidance technique increases the exploitation of the search technique by changing the position of the search agent related to the best fitness value. This increase in exploitation helps to select the relevant features and avoid overfitting problems. The input images are normalized and applied to AlexNet–ResNet50 model for feature extraction. The OG-WOA technique is applied in extracted features to select relevant features. Finally, the selected features are processed for classification using Bi-directional long short-term memory (Bi-LSTM). The proposed OG-WOA–Bi-LSTM technique has an accuracy of 97.12% on AID, 99.34% on UCM, and 96.73% on NWPU, SceneNet model has accuracy of 89.58% on AID, and 95.21 on the NWPU dataset.
Exploring the role of green animation advertising influencing green brand love and green customer citizenship behavior
Authors: Zhang Yipin , Yang Yi-Chun
Published: January 2023

This study applied the theory of stimulus–organism–response to test the role of green animation advertising influencing green brand love and green customer citizenship behavior. We used questionnaire survey and the target are those who having the experience of seeing the Apple’s animation advertisement “Earth Day” in China. Finally there were 516 effective samples gathered for analysis. The result indicated that reliability, attractiveness and informativity are the antecedents of green brand love. Green brand love is positively related to green customer citizenship behavior. In addition, the result confirmed the significant mediating effect of green brand love between reliability, attractiveness, informativity and green customer citizenship behavior. This research was conducted only in Apple’s animation case. Hence, the results may not be generalizable to other contexts. Future research can apply the experimental methods and manipulate different forms of green advertising animation to generalize the findings in this area.
Marital dissolution and associated factors in Hosanna, Southwest Ethiopia: a community-based cross-sectional study
Authors: Asfaw Likawunt Samuel , Alene Getu Degu
Published: January 2023

Background

Marriage dissolution, divorce, or separation from a spouse or common-law partner is a serious public health concern due to its increasing prevalence and devastating health and socio-economic consequences. Evidence suggests an increased risk of marital instability in Ethiopia. In addition, the extent of marital dissolution and other related factors have increased in the study area. Despite these, the prevalence of marital dissolution and the influence of associated factors (main reason for marriage, and parental history of marital dissolution) on marital dissolution has not been assessed in the study area. Therefore, the aim of this study was to investigate the prevalence of marital dissolution and its associated factors among residents of Hosanna town in southwestern Ethiopia in 2022.

Methods

We conducted a community-based cross-sectional study among 459 randomly selected Hosanna Township residents. We used structured questionnaires to collect data. Descriptive statistics and logistic regression were performed to describe the data and test-associated factors, respectively. A p-value less than 0.05 was used to define statistical significance. We used STATA 14 and IBM SPSS 25.0 computer packages to process data.

Results

Out of the 459 potentially eligible individuals, 450 participants properly responded to the questionnaires yielding a response rate of 98.04%. Of these, 218 (52.9%) were female. The commonly reported reason for marriage was to have children 150 (36.9%). The prevalence rate of marital dissolution was 26.0% (95% CI: (21.7%, 30.3%)). The participant's level of education and the primary reasons (motives) why they get married were statistically significantly associated with marital dissolution. The odds of marital dissolution was higher among participants who completed secondary education (AOR = 3.2, 95% CI = 1.26–8.17) compared to those having no formal education. The participants who married for companionship reasons (AOR = 0.31, 95% CI = 0.11–0.83) had significantly lower odds of marriage dissolution compared with those who married for financial security.

Conclusions

In this study, the prevalence of marital dissolution was high. The participant’s level of education and the primary reasons (motives) why they getting married were significantly associated with marital dissolution. Therefore, an integrated, community-based approach should be developed to prevent marital dissolution.
The clinical and genomic distinctions of Class1/2/3 BRAF-mutant colorectal cancer and differential prognoses
Authors: Chen Yungchang , Sun Hao , Deng Yanhong , Ma Yutong , Huang He , Liu Yang , Zhang Yaru , Zhang Hongyu , Ye Sheng , E Mingyan , Guo Hongqiang , Wu Mengmeng , Wu Chunman , Pu Xingxiang , Chen Xinggui , Liang Chaoyong , Ou Qiuxiang , Weng Huawei , Wu Xue , Shao Yang , Gu Anxin , Lin Tongyu
Published: January 2023

BRAF mutations are the oncogenic drivers in colorectal cancer and V600 mutations (Class1), which lead to RAS-independent active monomers, are the most common mutation types. BRAF non-V600 mutants can be further classified as RAS-independent active dimers (Class2) and RAS-dependent impaired kinase (Class3). We retrospectively reviewed the mutational profiles of 328 treatment-naïve colorectal tumors with BRAF mutations detected using capture-based hybrid next-generation sequencing targeting 400 + cancer-related genes. The clinical and genetic distinctions of patients harboring Class1/2/3 BRAF mutations were investigated, which revealed that tumors with Class1 BRAF mutations showed more unique genomic profiles than those with Class2/3 mutations. Also, by using an external dataset from cBioPortal, we demonstrated that patients with Class3 BRAF mutations had the best survival outcomes compared to the other two subgroups. These findings promoted the development of anti-BRAF strategies by distinguishing BRAF mutant subgroups.
PET-based radiomics visualizes tumor-infiltrating CD8 T cell exhaustion to optimize radiotherapy/immunotherapy combination in mouse models of lung cancer
Authors: Zhang Ying , Hu Hui-Hui , Zhou Shi-Hong , Xia Wu-Yan , Zhang Yan , Zhang Jian-Ping , Fu Xiao-Long , Yu Wen
Published: January 2023

Background

Cumulative preclinical and clinical evidences showed radiotherapy might augment systemic antitumoral responses to immunotherapy for metastatic non-small cell lung cancer, but the optimal timing of combination is still unclear. The overall infiltration and exhausted subpopulations of tumor-infiltrating CD8+ T cells might be a potential biomarker indicating the response to immune checkpoint inhibitors (ICI), the alteration of which is previously uncharacterized during peri-irradiation period, while dynamic monitoring is unavailable via repeated biopsies in clinical practice.

Methods

Basing on tumor-bearing mice model, we investigated the dynamics of overall infiltration and exhausted subpopulations of CD8+ T cells after ablative irradiation. With the understanding of distinct metabolic characteristics accompanied with T cell exhaustion, we developed a PET radiomics approach to identify and visualize T cell exhaustion status.

Results

CD8+ T cell infiltration increased from 3 to 14 days after ablative irradiation while terminally exhausted populations significantly predominated CD8+ T cells during late course of this infiltrating period, indicating that 3–7 days post-irradiation might be a potential appropriate window for delivering ICI treatment. A PET radiomics approach was established to differentiate T cell exhaustion status, which fitted well in both ICI and irradiation settings. We also visualized the underlying association of more heterogeneous texture on PET images with progressed T cell exhaustion.

Conclusions

We proposed a non-invasive imaging predictor which accurately assessed heterogeneous T cell exhaustion status relevant to ICI treatment and irradiation, and might serve as a promising solution to timely estimate immune-responsiveness of tumor microenvironment and the optimal timing of combined therapy.
BEGL: boundary enhancement with Gaussian Loss for rock-art image segmentation
Authors: Bai Chuanping , Liu Yangyang , Zhou Pengbo , Wang Xiaofeng , Zhou Mingquan
Published: January 2023

Rock-art has been scratched, carved, and pecked into rock panels all over the world resulting in a huge number of engraved figures on natural rock surfaces that record ancient human life and culture. To preserve and recognize these valuable artifacts of human history, 2D digitization of rock surfaces has become a suitable approach due to the development of powerful 2D image processing techniques in recent years. In this article, we present a novel systematical framework for the segmentation of different petroglyph figures from 2D high-resolution images. The novel boundary enhancement with Gaussian loss (BEGL) function is proposed aiming at refining and smoothing the rock-arts boundaries in the basic UNet architecture. Several experiments on the 3D-pitoti dataset demonstrate that our proposed approach can achieve more accurate boundaries and superior results compared with other loss functions. The comprehensive framework of petroglyph segmentation from 2D high-resolution images provides the foundation for recognizing multiple petroglyph marks. The framework can then be extended to other cultural heritage digital protection domain easily.
Preoperative Ahlbäck radiographic classification grade significantly influences clinical outcomes of double level osteotomy for osteoarthritic knees with severe varus deformity
Authors: Nakayama Hiroshi , Kanto Ryo , Onishi Shintaro , Amai Kenta , Ukon Ryosuke , Tachibana Toshiya , Yoshiya Shinichi , Iseki Takuya , Morimoto Shota , Iseki Tomoya
Published: January 2023

Purpose

The purpose of this study was to examine the relationship between preoperative Ahlbäck radiographic classification grade and the clinical outcomes of double level osteotomy (DLO) performed for osteoarthritic knees with severe varus deformity.

Methods

The study population comprised a consecutive series of 99 knees (68 patients) for which DLO was performed and follow‐up results for a minimum of two years were available. The Ahlbäck radiographic classification system was used to determine the osteoarthritic grade. The following radiological parameters for alignment and bone geometry were measured: mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle (mMPTA), joint‐line convergence angle (JLCA), and mechanical tibiofemoral angle (mTFA). Clinical results were assessed using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the International Knee Documentation Committee (IKDC) subjective score preoperatively and at 2 years after surgery. Difference between preoperative and postoperative measurements as well as relationship between Ahlbäck grade and radiological/clinical results were statistically assessed.

Results

The average age of the study participants was 60.9 ± 6.2 years and the mean follow‐up period was 45.4 ± 15.2 months. Each of the radiological parameters exhibited preoperative abnormal values. Knees with Ahlbäck grade 3 and 4 osteoarthritis exhibited significantly greater JLCA and mTFA than grade 1 knees. Two years post‐surgery, all radiological parameter values measured within a normal range. Clinical evaluation showed significant improvement in KOOS after surgery. Analysis of the relationship between Ahlbäck grade and clinical score showed that the 2‐year postoperative KOOS scores in grade 3 and 4 osteoarthritic knees were significantly lower than grade 1 knees (with the mean 2‐year KOOS scores of 350.0 ± 79.9, 317.9 ± 78.3, and 420.2 ± 42.9, respectively).

Conclusions

While DLO may produce significant radiological and clinical improvement in knees with joint space obliteration, Ahlbäck grade 3 and 4 osteoarthritic knees associated with larger JLCA and mTFA showed less satisfactory clinical results compared to grade 1 knees. Level of Evidence: IV case series.
A systematic review of transphyseal ACL reconstruction in children and adolescents: comparing the transtibial and independent femoral tunnel drilling techniques
Authors: Petersen Wolf , Bierke Sebastian , Stöhr Amelie , Stoffels Thomas , Häner Martin
Published: January 2023

Purpose

Aim of this systematic review was to analyze the outcome after transphyseal ACL reconstruction in children and adolescents regarding the femoral drilling technique.

Methods

A systematic literature search was carried out in various databases on studies on transphyseal ACL reconstruction in children and adolescents. The literature search was limited to the last 20 years. Primary outcome criterion was the failure rate. Secondary outcome criteria were growth disturbances such as leg length discrepancies or deformities and clinical scores.

The present study was registered prospectively (www.crd.york.ac.uk/PROSPERO; CRD42022345964).

Results

A total of 22 retrospective or prospective case series (level 4 evidence) were identified that reported on transphyseal ACL reconstruction in children and adolescents. The overall failure/rupture rate after transphyseal ACL reconstruction was 11.0%. The overall ACL rupture rate of the contralateral side was 9.7%. No statistical significant difference in the failure rates between independent and transtibial drilling techniques could be detected ((p = 0.76/p = 0.28)). Furthermore no statistical significant differences in the rate of reported growth disturbances between independent and transtibial drilling techniques were shown (p = 0.15). The reported clinical scores at follow‐up (mean follow‐up 5.05 years) revealed good to very good results.

Conclusion

This systematic review demonstrates that children and adolescents have a relatively high failure rate after transpyseal ACL reconstruction without any statistically significant differences between independent or transtibial drilling techniques regarding reruptur rates or the rate of growth disturbances. The results of this systematic review warrant a comparison of both techniques for femoral tunnel drilling in a controlled randomized trial.
Cordyceps militaris polysaccharides: preparation and topical product application
Authors: Kanlayavattanakul Mayuree , Lourith Nattaya
Published: January 2023

Background

Topical product derived from the fungus Cordyceps militaris was explored as a feasible method for an industrial practice.

Results

The mycelium residue of C. militaris that was industrial biotechnological produced was extracted with water at different time conditions under ambient temperature, filtered and lyophilized. The extracts were all light to dark brown powder. The 24 h extraction was significantly (p < 0.01) highest in an extractive yield and total polysaccharides content (TPC) (43.33 ± 0.99% and 144.02 ± 2.06 mg glucose/g crude extract). This extract was proved to be stable following an accelerated stability test with the insignificant (p > 0.05) reduction of TPC (4.95 ± 2.23%). Topical product containing the extract were developed. Skin care preparation containing 0.2% extract was exhibited as the appropriated amount giving the stable cream. The developed C. militaris polysaccharide cream was confirmed safe and gained more than 70% of the overall preferences examined in 20 female volunteers.

Conclusions

Cordyceps militaris mycelium residue is a beneficial source for pharmaceutical products. The C. militaris polysaccharides extract was prepared and qualified in terms of active content and stability. The extract was shown to be compatible with the available cosmetic ingredients. The safe and preferred C. militaris polysaccharides skin care cosmetics was developed. Accordingly, C. militaris polysaccharides skin care cosmetics that meets all the quality characters which are stable, safe, usable and efficient.
Cancer incidence and mortality in patients diagnosed with heart failure: results from an updated systematic review and meta-analysis
Authors: Camilli Massimiliano , Chiabrando Juan Guido , Lombardi Marco , Del Buono Marco Giuseppe , Montone Rocco Antonio , Lombardo Antonella , Crea Filippo , Minotti Giorgio
Published: January 2023

Background

Several cohort studies aimed at demonstrating an increased risk of cancer incidence and mortality in patients with a pre-existing diagnosis of heart failure (HF); however, conflicting results have been reported that call for systematic review and meta-analysis.

Methods

We conducted a systematic search of multiple databases from their inception through July 2022 and retrieved only papers reporting hazard ratios (HR). Random and fixed-effects models were fit for the study duration.

Results

The analysis included nine cohort studies for a total of 515′041 HF cases and 1′365’452 controls without HF. Although high heterogeneity among studies was observed, the HR for incident cancer in HF patients was statistically significant (1.45, 95% CI 1.31–1.61, p < 0.0001), which was confirmed by sensitivity analyses; however, by analyzing the few papers reporting HRs for cancer mortality, no significant difference between HF and non-HF patients could be detected (HR 2.03, 95% CI [0.93–4.43], p = 0.0736). Further scrutiny of studies with adjusted HRs, when available, confirmed that cancer incidence was significantly increased in patients with HF, as was cancer mortality as well.

Conclusions

This meta-analysis shows that HF patients are at an increased risk of incident cancer. Increased mortality could not be firmly demonstrated by the available data. Our results call for inclusion of cancer-related endpoints in HF trials to adequately address this important clinical issue.
Telehealth: a new opportunity for out-patient psychiatric services
Authors: Bell Erica , Kaufmann Cornelia , Malhi Gin S.
Published: January 2023

In the wake of the COVID-19 pandemic, healthcare systems rapidly embraced technology as a means of providing care while adhering to social distancing protocols. In this brief article, we report on a new telehealth initiative recently implemented in an out-patient psychiatric setting and outline the novel role telehealth may serve in facilitating psychiatric care globally. The uptake of telehealth represents a new and exciting opportunity to increase both access to, and quality of, care for people with mental illness.
The Burden of Surviving Childhood Medulloblastoma: A Population-Based, Matched Cohort Study in Ontario, Canada
Authors: Coltin Hallie , Pequeno Priscila , Liu Ning , Tsang Derek S. , Gupta Sumit , Taylor Michael D. , Bouffet Eric , Nathan Paul C. , Ramaswamy Vijay
Published: January 2023

PURPOSE

Survivors of childhood medulloblastoma suffer from substantial late effects. We characterized these sequelae using real-world health services data in a population-based cohort of medulloblastoma survivors.

METHODS

All 5-year medulloblastoma survivors diagnosed age < 18 years between 1987 and 2015 in Ontario, Canada, were identified and matched 1:5 with population controls. Index date was 5 years from latest pediatric cancer event. Linkage to provincial administrative health data allowed for comparison of cumulative incidences of several adverse outcomes.

RESULTS

Two hundred thirty survivors, 81.3% of whom had received craniospinal irradiation, were matched with 1,150 controls. The 10-year postindex cumulative incidence of all-cause mortality was 7.9% (95% CI, 3.9 to 11.8) in survivors versus 0.6% (95% CI, 0.1 to 1.1) in controls (hazard ratio [HR], 21.5; 95% CI, 9.8 to 54.0). The cumulative incidence of stroke was higher in survivors (4.8%; 95% CI, 2.2 to 9.0) compared with controls (0.1; 95% CI, 0.01 to 0.7; HR, 45.6; 95% CI, 12.8 to 289.8). Hearing loss requiring an amplification device was present in 24.9% (95% CI, 18.8 to 31.4) of survivors versus 0.3% (95% CI, 0.1 to 1.0) of controls (HR, 96.3; 95% CI, 39.7 to 317.3). Disability support prescription claims were submitted by 44.5% (95% CI, 37.1 to 51.6) of survivors versus 5.5% (95% CI, 4.2 to 7.1) of controls (HR, 10.0; 95% CI, 7.3 to 13.6). Female survivors were significantly less likely to deliver a liveborn child compared with controls (HR, 0.2; 95% CI, 0.1 to 0.7).

CONCLUSION

Survivors of medulloblastoma have significant long-term medical sequelae, increased all-cause mortality, and are frequently dependent on disability supports. Efforts to reduce the toxicity of current therapy, specifically incorporating molecularly informed risk stratification to spare low- and intermediate-risk survivors the toxicity of treatment, are urgently needed. These findings should prompt a re-evaluation of our current treatment approaches where research focused on late-effect interventions should be prioritized.

[Media: see text]
Formal and Informal Alliances between Iberians and Natives in the Heart of Late Eighteenth-Century South America
Authors: Carvalho Francismar Alex Lopes de
Published: January 2023

For decades, historiography on the Iberian empires has suggested that peace treaties between Europeans and autonomous Native groups incorporated both Indigenous “nations,” understood as cohesive units, and Native lands into the monarchy. Drawing on extensive archival evidence and recent borderlands scholarship, this article suggests that written agreements had a limited impact on interethnic frontier relations. First, because informal relations shaped by Indigenous patterns of diplomacy were far more important to the success of alliances. Second, because alliances were often made with autonomous tolderías, not with homogeneous “nations.” And third, because Natives by no means identified their ethnic territories with Crown possessions, but continued to independently exploit Iberian rivalries in order to achieve more favorable conditions for themselves. This article focuses on the frontier between the Spanish province of Paraguay and the Portuguese captaincy of Mato Grosso.
Style and Rebus in an Emergent Script from Bolivia: The Koati Variant of Andean Pictographic Writing
Authors: Hyland Sabine
Published: January 2023

Andean pictographic writing, once considered the creation of foreign missionaries, is now recognized as a series of locally developed scripts that emerged after contact with alphabetic writing. However, the role of stylistic variation within the Andean pictographic scripts is little understood, nor has the rebus-based glottography of the system’s phonetic signs been fully studied. This article examines the Koati variant of Andean pictographic script from Bolivia’s Island of the Moon, based in part on a newly found pictographic manuscript preserved on animal hides in Harvard University’s Peabody Museum. It analyzes how script styles in the Titicaca area correspond to regional groups and explores the nature of rebus signs in the Koati variant, identifying the principles underlying successful homonymic equivalences. Many of the characters in Andean pictographic writing appear to draw from a repository of Indigenous visual signs that predate the Spanish invasion; research into the emergent pictorial scripts of Peru and Bolivia may provide insights into the meaning of visual signs in other forms of Andean inscription, such as ceramics and khipus.
Sickness of the Revolution
Authors: Odabaei Milad
Published: January 2023

Conventional accounts of the 1979 Iranian revolution emphasize the loss of the revolution's “true” spirit in the violence of the Islamic state. In contrast, this essay foregrounds a recurring dream of parricide in the generation of children of revolutionaries to explore the fetishization of the revolution in such accounts. This dream refracts the violence and loss emphasized in the narratives of the revolution. In dethroning the fetish of the revolution, it enables a confrontation with the losses and limits of earlier theological and political paradigms indexed by the event of revolution. As a form of anthropological defamiliarization, the dream thus offers an opportunity for a speculative encounter with loss as a political-theological horizon of renewal.
Correlation analysis of systemic immune inflammatory index, Serum IL-35 and HMGB-1 with the severity and prognosis of sepsis
Authors: Ma Ke , Zhang Yajuan , Hao Jian , Zhao Jing , Qi Ying , Liu Cong
Published: January 2023

Objective: To investigate the correlation between systemic immune inflammatory (SII) index, serum interleukin-35 (IL-35) and high mobility Group-Box one (HMGB-1) with the severity and prognosis of sepsis.

Methods: A retrospective analysis was performed on the clinical data of 209 patients with sepsis admitted to Ganzhou City People’s Hospital from October 2019 to October 2021. One hundred eighteen patients in Group-A had common sepsis, and 91 patients in Group-B had septic shock, which were subdivided into the survival Group-And the mortality Group-According to the 28d prognosis. The levels of SII, IL-35 and HMGB-1 in different groups were compared, and their correlation with the severity and prognosis of sepsis was analyzed.

Results: The levels of SII, IL-35 and HMGB-1 in Group-A were significantly lower than those in Group-B (p<0.05). The levels of SII, IL-35 and HMGB-1 in the survival group were significantly lower than those in the death group (p<0.05). Spearman correlation analysis showed that the levels of SII, IL-35, and HMGB-1 were significantly positively correlated with the severity of sepsis (p<0.05), and significantly positively correlated with the prognosis of patients with sepsis (p<0.05).

Conclusion: SII, IL-35 and HMGB-1 are remarkably correlated with the severity and prognosis of patients with sepsis. With the increasing in SII, IL-35 and HMGB-1 levels, patients will suffer from severe disease progression and poor prognosis, which require more clinical attention.

doi: https://doi.org/10.12669/pjms.39.2.6651

How to cite this: Ma K, Zhang Y, Hao J, Zhao J, Qi Y, Liu C. Correlation analysis of systemic immune inflammatory index, Serum IL-35 and HMGB-1 with the severity and prognosis of sepsis. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6651

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linkages between poverty and food insecurity in Pakistan: Evidence from urban and rural households in Peshawar
Authors: Kibria Zeeshan , Nasim Khan Muhammad , Aleem Saima , Zia Ul Haq
Published: January 2023

Objective: To assess household poverty, sanitation and hygiene practices, and food security in both urban and rural settlements of district Peshawar.

Methods: We conducted this cross-sectional study from March 2019 to October 2019 in the urban and rural households of Peshawar, KPK. Using stratified random sampling, 554 households (HH) having children and young adolescents of age 5-19 years, adult men > 19 – 62 years, and adult women >19 - 62 years were included in this study. Data was collected using comprehensive tool comprised of all validated questionnaires and was analyzed using SPSS Version 24.0.

Results: Within the urban clusters, the maximum number of households (n=29) were from Gari Baloch and the minimum number of households (n=7) were from Gulberg. In the rural clusters, the maximum number of households surveyed (n=41) were from Lamara, minimum(n=21) was from Chargula. The average age of household heads was 44.5 ±12.5 with mean age slightly higher in urban areas (45.1 ±11.8) compared to 44.0 ±13.2 in rural areas. The mean poverty score was 56.8 (±11.6) with 72.1% non-poor households, and 94.2% households being food secure. Handwashing practices were highly prevalent among all the HH, however, handwashing practices before eating were comparatively lower in all HH (45.2%), lowest (37.8%) among rural households.

Conclusion: The findings of the study revealed both non-poor and food secure households with satisfactory water, hygiene and sanitation practices.

doi: https://doi.org/10.12669/pjms.39.2.7122

How to cite this: Kibria Z, Khan MN, Aleem S, Zia ul Haq. Linkages between poverty and food insecurity in Pakistan: Evidence from urban and rural households in Peshawar. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.7122

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A Byzantine Poetic Form in a Ninth-Century Bulgarian Poem
Authors: Dikova Ekaterina
Published: January 2023

The paper measures the extent to which the most characteristic features related to the so-called Byzantine dodecasyllable are applied in one of the earliest Old-Bulgarian poems – Azbuchna molitva (‘Alphabetic Prayer’) noted to be written in dodecasyllabic verses. This alphabetic acrostic is dated back to the very end of the ninth century and is attributed to Constantine of Preslav. In this article its text is given after its earliest copy, MS Syn. 262, as it is the only representative of the version closest to the Glagolitic archetype, now lost. The piece is studied in comparison with St Gregory the Theologian’s alphabetic acrostic (as published in PG 37) which Constantine of Preslav quotes just after the end of his poem and which is considered its rhythmical model. The main conclusions are that the Alphabetic Prayer is an early replica of the Byzantine dodecasyllable, follows its rhythmical peculiarities to an extent similar to St Gregory’s alphabetic acrostic, all the previously supposed deviations are motivated by genre peculiarities and rhetorical requirements, which reveals Byzantine schooling of the Old-Bulgarian writer. Nevertheless, the content and intention of the poem indubitably target the neophyte Slavonic audience.
Frontiers in Comparative Metrics IV, 16–17 September 2022, Tallinn, Estonia
Authors: Trunin Mikhail
Published: January 2023

Frontiers in Comparative Metrics IV, 16–17 September 2022, Tallinn, Estonia
Revisiting psychiatric support for the National Socialist Agenda in Germany: Implications for medical and residency training
Authors: McMahon Terry , Ali Hisham , Bundoc-Baronia Regina , McGovern Thomas
Published: January 2023

The transition of power from a failing Weimer Republic to the National Socialist (Nazi) government was characterized by many economic and politically-motivated changes. Economic crises and the overcrowding of psychiatric hospitals in Germany were the setting for these events. The eugenics movement, although not unique to Germany in the 1920s, would eventually culminate in the compulsory sterilization, euthanasia, and extermination in concentration camps. Historical accounts tend to focus on political and military leaders with the role of medical professionals often overlooked or forgotten. Additionally, there are connections between these programs and medical research. This article aims to elucidate the factors that influenced their role in this historical tragedy and their current implications on how physicians train, learn, and practice role of the medical professionals.
Trapped lung: a review of literature and recent cases
Authors: Vangipuram Divya
Published: January 2023

A trapped lung, one that cannot expand due to a restrictive fibrous visceral pleural peel, is caused by malignancy, chest trauma, thoracic surgery, complicated infection, and autoimmune conditions. Suspicion for and evaluation of this condition should be considered early on in a patient with history of the above conditions that presents with a chronic pleural effusion of stable volume. Diagnosis is reached with pleural fluid analysis, manometry that shows negative intrapleural pressure that is further reduced with fluid aspiration, and imaging that shows a chronic effusion and pleural thickening. Treatment is dependent on symptomatology and overall patient condition, and ranges from observation to fluid removal, fibrinolytic therapy, talc pleurodesis, indwelling pleural catheter, and surgical decortication. A review of English literature from the last 10 years including case reports, case series, and observational reviews was conducted. A majority of these patients presented with trapped lung due to malignancy, infection, or autoimmune conditions. Treatment varied depending on the cause of the trapped lung, underlying conditions, and patient preference; a majority of these patients received either pleurodesis, intrapleural fibrinolytic therapy, or surgical decortication.