bluuebunny/crossref_metadata_2025 huggingface dataset:
The Lake Home: International Law and the Global Land Grab
Authors: ZEFFERT Henrietta
Published: September 2017

Home is not a familiar concept in international law. This paper looks at land grabbing and international law from the perspective of home. Through a case-study of a land grab in the context of a World Bank development project at Boeung Kak Lake in Phnom Penh, Cambodia, it argues that international law is involved in profound transformations of home. By making visible how experiences of loss, suffering, and struggle, as well as radical engagement, emerge from international law’s “homemaking” work, it also argues that the concept of home opens up a terrain of experience that cannot be captured or expressed in international law. The perspective from home in the land-grabbing debate is particularly important where not only is land at risk of capture for economic gain, but so too are the personal lifeworlds that homes represent.
Wie Eltern und ihre Kinder die pflegegeleitete Transitionssprechstunde für Adoleszente mit angeborenen Herzfehlern erleben
Authors: Thomet Corina , Lindenberg Carina , Schwerzmann Markus , Spichiger Elisabeth
Published: September 2017

Zusammenfassung.Hintergrund: Heute erreichen bis zu 90 % der Patientinnen/Patienten mit angeborenem Herzfehler (AHF) das Erwachsenenalter. Um Betreuungsunterbrüche beim Übergang von der Pädiatrie in die Erwachsenenmedizin zu vermeiden, wurde am Inselspital Universitätsspital Bern eine pflegegeleitete Transitionssprechstunde (TS) eingeführt. Ziel: Es wurde exploriert, wie Adoleszente mit AHF und ein Elternteil den Transfer sowie die TS erlebten und welche Erwartungen sie hatten. Methode: Für die qualitative Studie mit interpretierendem phänomenologischem Ansatz wurden Einzelinterviews mit sieben Adoleszenten, sechs Müttern und zwei Vätern durchgeführt und in einem iterativen Prozess analysiert. Ergebnisse: Der Transfer Pädiatrie – Erwachsenenkardiologie im Rahmen der TS verlief für die Studienteilnehmenden mehrheitlich problemlos. Die TS erlebten sie positiv. Die Adoleszenten schätzten eine konstante Ansprechperson, die ihnen Wissen zum AHF vermittelte. Mütter und Väter begrüssten die Unterstützung ihrer Kinder im Alltag durch eine sachkundige, neutrale Fachperson. Im Übernehmen von Verantwortung für ihren AHF waren die Adoleszenten unterschiedlich weit. Den Müttern und den Vätern fiel die Abgabe von Verantwortung nicht leicht. Sie waren jedoch dazu bereit, wollten den Adoleszenten aber die nötige Zeit lassen, schliesslich selber verantwortlich zu handeln. Schlussfolgerungen: Die Transitionssprechstunde ist ein wichtiges Instrument, um Kontinuität in der Betreuung der Adoleszenten zu gewährleisten und ihren Eltern das Übergeben der Verantwortung an die Jugendlichen zu erleichtern.
How Social and Refractory Is the Social Psychological Refractory	Period?
Authors: Wühr Peter , Heuer Herbert
Published: September 2017

Abstract. The social psychological refractory period (PRP) effect refers to an increase in RT to the second of two successive stimuli when another person responds to the first stimulus (shared dual-task condition) rather than when a single person responds to both stimuli (individual dual-task condition). We investigated (a) whether a social PRP effect would occur without explicit instruction concerning task priority and (b) whether there are crosstalk effects in the shared dual-task situation. We observed a strong PRP effect together with a small crosstalk effect in the individual dual-task condition, but in the shared dual-task condition both effects were absent. These findings suggest that the explicit instruction to perform responses in a fixed order is necessary to obtain the social PRP effect. In the individual dual-task condition, sequential processing can be seen as a means to reduce or prevent crosstalk effects, which is not necessary in the shared dual-task condition.
ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
Authors: Li Lifang , Liu Xinhua , He Lin , Yang Jianguo , Pei Fei , Li Wanjin , Liu Shumeng , Chen Zhe , Xie Guojia , Xu Bosen , Ting Xia , Zhang Zihan , Jin Tong , Liu Xujun , Zhang Wenting , Yuan Shuai , Yang Ziran , Wu Chongyang , Zhang Yu , Yang Xiaohan , Yi Xia , Liang Jing , Shang Yongfeng , Sun Luyang
Published: September 2017

EGFR is required for animal development, and dysregulation of EGFR is critically implicated in malignant transformation. However, the molecular mechanism underlying the regulation of EGFR expression remains poorly explored. Here we report that the zinc-finger protein ZNF516 is a transcription repressor. ZNF516 is physically associated with the CtBP/LSD1/CoREST complex and transcriptionally represses a cohort of genes including EGFR that are critically involved in cell proliferation and motility. We demonstrate that the ZNF516–CtBP/LSD1/CoREST complex inhibits the proliferation and invasion of breast cancer cells in vitro and suppresses breast cancer growth and metastasis in vivo. Significantly, low expression of ZNF516 is positively associated with advanced pathological staging and poor survival of breast carcinomas. Our data indicate that ZNF516 is a transcription repressor and a potential suppressor of EGFR, adding to the understanding of EGFR-related breast carcinogenesis and supporting the pursuit of ZNF516 as a potential therapeutic target for breast cancer.
Targeted gadofullerene for sensitive magnetic resonance imaging and risk-stratification of breast cancer
Authors: Han Zheng , Wu Xiaohui , Roelle Sarah , Chen Chuheng , Schiemann William P. , Lu Zheng-Rong
Published: September 2017

Molecular imaging of cancer biomarkers is critical for non-invasive accurate cancer detection and risk-stratification in precision healthcare. A peptide-targeted tri-gadolinium nitride metallofullerene, ZD2-Gd3N@C80, is synthesised for sensitive molecular magnetic resonance imaging of extradomain-B fibronectin in aggressive tumours. ZD2-Gd3N@C80 has superior r1 and r2 relaxivities of 223.8 and 344.7 mM−1 s−1 (1.5 T), respectively. It generates prominent contrast enhancement in aggressive MDA-MB-231 triple negative breast cancer in mice at a low dose (1.7 µmol kg−1, 1 T), but not in oestrogen receptor-positive MCF-7 tumours. Strong tumour contrast enhancement is consistently observed in other triple negative breast cancer models, but not in low-risk slow-growing tumours. The dose of the contrast agent for effective molecular MRI is only slightly higher than that of ZD2-Cy5.5 (0.5 µmol kg−1) in fluorescence imaging. These results demonstrate that high-sensitivity molecular magnetic resonance imaging with ZD2-Gd3N@C80 may provide accurate detection and risk-stratification of high-risk tumours for precision healthcare of breast cancer.
Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I
Authors: El Yakoubi Warif , Buffin Eulalie , Cladière Damien , Gryaznova Yulia , Berenguer Inés , Touati Sandra A. , Gómez Rocío , Suja José A. , van Deursen Jan M. , Wassmann Katja
Published: September 2017

A key feature of meiosis is the step-wise removal of cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I and then from the centromere region in meiosis II. Centromeric cohesin is protected by Sgo2 from Separase-mediated cleavage, in order to maintain sister chromatids together until their separation in meiosis II. Failures in step-wise cohesin removal result in aneuploid gametes, preventing the generation of healthy embryos. Here, we report that kinase activities of Bub1 and Mps1 are required for Sgo2 localisation to the centromere region. Mps1 inhibitor-treated oocytes are defective in centromeric cohesin protection, whereas oocytes devoid of Bub1 kinase activity, which cannot phosphorylate H2A at T121, are not perturbed in cohesin protection as long as Mps1 is functional. Mps1 and Bub1 kinase activities localise Sgo2 in meiosis I preferentially to the centromere and pericentromere respectively, indicating that Sgo2 at the centromere is required for protection.
Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control
Authors: Kulaberoglu Yavuz , Lin Kui , Holder Maxine , Gai Zhongchao , Gomez Marta , Assefa Shifa Belul , Mavis Merdiye , Hoa Lily , Sharif Ahmad A. D. , Lujan Celia , Smith Ewan St. John , Bjedov Ivana , Tapon Nicolas , Wu Geng , Hergovich Alexander
Published: September 2017

The Hippo tumor suppressor pathway is essential for development and tissue growth control, encompassing a core cassette consisting of the Hippo (MST1/2), Warts (LATS1/2), and Tricornered (NDR1/2) kinases together with MOB1 as an important signaling adaptor. However, it remains unclear which regulatory interactions between MOB1 and the different Hippo core kinases coordinate development, tissue growth, and tumor suppression. Here, we report the crystal structure of the MOB1/NDR2 complex and define key MOB1 residues mediating MOB1’s differential binding to Hippo core kinases, thereby establishing MOB1 variants with selective loss-of-interaction. By studying these variants in human cancer cells and Drosophila, we uncovered that MOB1/Warts binding is essential for tumor suppression, tissue growth control, and development, while stable MOB1/Hippo binding is dispensable and MOB1/Trc binding alone is insufficient. Collectively, we decrypt molecularly, cell biologically, and genetically the importance of the diverse interactions of Hippo core kinases with the pivotal MOB1 signal transducer.
Direct observation of mode-specific phonon-band gap coupling in methylammonium lead halide perovskites
Authors: Kim Heejae , Hunger Johannes , Cánovas Enrique , Karakus Melike , Mics Zoltán , Grechko Maksim , Turchinovich Dmitry , Parekh Sapun H. , Bonn Mischa
Published: September 2017

Methylammonium lead iodide perovskite is an outstanding semiconductor for photovoltaics. One of its intriguing peculiarities is that the band gap of this perovskite increases with increasing lattice temperature. Despite the presence of various thermally accessible phonon modes in this soft material, the understanding of how precisely these phonons affect macroscopic material properties and lead to the peculiar temperature dependence of the band gap has remained elusive. Here, we report a strong coupling of a single phonon mode at the frequency of ~ 1 THz to the optical band gap by monitoring the transient band edge absorption after ultrafast resonant THz phonon excitation. Excitation of the 1 THz phonon causes a blue shift of the band gap over the temperature range of 185 ~ 300 K. Our results uncover the mode-specific coupling between one phonon and the optical properties, which contributes to the temperature dependence of the gap in the tetragonal phase.
Characterization of intrinsic hole transport in single-crystal spiro-OMeTAD
Authors: Li Yuan , Li Haoyuan , Zhong Cheng , Sini Gjergji , Brédas Jean-Luc
Published: September 2017

Spiro-OMeTAD remains a prominent hole-transport material in perovskite and solid-state dye-sensitized solar cells. However, an understanding of its intrinsic hole-transport properties is still limited. Here, hole transport in spiro-OMeTAD is systematically characterized on the basis of the recently reported X-ray single-crystal data. An approach combining density functional theory calculations, tight-binding modeling, and kinetic Monte Carlo simulations are exploited to describe the key parameters governing hole transport and to investigate the transport mechanism and hole mobilities in the spiro-OMeTAD single crystal. The results provide insight into: (i) why an anisotropic hole-transport mechanism, with an upper range of intrinsic hole mobilities on the order of ~10−3 cm2/Vs, can be expected in the single crystal; and (ii) how detrimental factors, related to the presence of the spiro motif and of the 4,4′-dimethoxydiphenylamine substituents, limit the intrinsic hole mobilities of the system.
Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition
Authors: Lima-Posada Ixchel , Portas-Cortés Cinthya , Pérez-Villalva Rosalba , Fontana Francesco , Rodríguez-Romo Roxana , Prieto Rodrigo , Sánchez-Navarro Andrea , Rodríguez-González Guadalupe L. , Gamba Gerardo , Zambrano Elena , Bobadilla Norma A.
Published: September 2017

This study evaluated if there is a sexual dimorphism in the acute kidney injury (AKI) to chronic kidney disease (CKD) transition and the time-course of the potential mechanisms involved in the dimorphic response. Female and male rats were divided into sham-operated or underwent 45-min renal ischemia (F + IR, and M + IR). All groups were studied at 24-h and 1, 2, 3, or 4-months post-ischemia. Additionally, oophorectomized rats were divided into sham or IR groups. After 24-h, AKI extent was simllar in females and males, but female rats exhibited less oxidative stress and increased renal GSH content. After 4-months and despite similar AKI, the M + IR group developed CKD characterized by proteinuria, tubulointerstitial fibrosis, glomerular hypertrophy, increased oxidative stress and a reduction in HIF1α and VEGF from the 1st-month and persisting throughout the time-course studied. Interestingly, the F + IR group did not develop CKD due to lesser oxidative stress and increased eNOS, TGFβ and HIF1α mRNA levels from the 1st-month after IR. Whereas, oophorectomized rats did develop CKD. We found a sexual dimorphic response in the AKI to CKD transition. Early antioxidant defense and higher TGFβ, HIF1α and eNOS were among the renoprotective mechanisms that the F + IR group demonstrated.
Efficient feeder cells preparation system for large-scale preparation and application of induced pluripotent stem cells
Authors: Li Pengdong , Wang Shichao , Zhan Lixiang , He Xia , Chi Guangfan , Lv Shuang , Xu Ziran , Xia Yuhan , Teng Shuzhi , Li Lisha , Li Yulin
Published: September 2017

Despite recent progress in the preparation of feeder cells for human induced pluripotent stem cells (hiPSCs), there remain issues which limit the acquisition of feeder cells in large scale. Approaches for obtaining feeder cells quickly on a large scale are in immediate need. To reach this goal, we established suspension-adhesion method (SAM) and three-dimensional (3D) suspension method (3DSM). In SAM, mouse embryonic fibroblast (MEF) growth were fully inhibited by 10 μg/ml mitomycin-C (MMC) in 0.5 hours, and the feeder cells generated display higher adherent and recovery rates as well as longer survival time compared to conventional method (CM). 3DSM, an optimized method of SAM in which MEFs were cultured and MMC treated in suspension, was developed to lower the costs and workload using CELLSPIN System. The yield of feeder cells is several times the yield of SAM while the adherent and recovery rates and the capacity of supporting hiPSCs growth were not sacrificed. Hence, 3DSM is an economical and easy way to generate large-scale feeder cells for hiPSCs cultures.
Ventricular myocardium development and the role of connexins in the human fetal heart
Authors: Pervolaraki Eleftheria , Dachtler James , Anderson Richard A. , Holden Arun V.
Published: September 2017

The developmental timeline of the human heart remains elusive. The heart takes on its characteristic four chambered appearance by ~56 days gestational age (DGA). However, owing to the complexities (both technical and logistical) of exploring development in utero, we understand little of how the ventricular walls develop. To address this, we employed diffusion tensor magnetic resonance imaging to explore the architecture and tissue organization of the developing heart aged 95–143 DGA. We show that fractional anisotropy increases (from ~0.1 to ~0.5), diffusion coefficients decrease (from ~1 × 10−3mm2/sec to ~0.4 × 10−3mm2/sec), and fiber paths, extracted by tractography, increase linearly with gestation, indicative of the increasing organization of the ventricular myocytes. By 143 DGA, the developing heart has the classical helical organization observed in mature mammalian tissue. This was accompanied by an increase in connexin 43 and connexin 40 expression levels, suggesting their role in the development of the ventricular conduction system and that electrical propagation across the heart is facilitated in later gestation. Our findings highlight a key developmental window for the structural organization of the fetal heart.
Enhanced droplet collision rates and impact velocities in turbulent flows: The effect of poly-dispersity and transient phases
Authors: James Martin , Ray Samriddhi Sankar
Published: September 2017

We compare the collision rates and the typical collisional velocities amongst droplets of different sizes in a poly-disperse suspension advected by two- and three-dimensional turbulent flows. We show that the collision rate is enhanced in the transient phase for droplets for which the size-ratios between the colliding pairs is large as well as obtain precise theoretical estimates of the dependence of the impact velocity of particles-pairs on their relative sizes. These analytical results are validated against data from our direct numerical simulations. Our results suggest that an explanation of the rapid growth of droplets, e.g., in warm clouds, may well lie in the dynamics of particles in transient phases where increased collision rates between large and small particles could result in runaway process. Our results are also important to model coalescence or fragmentation (depending on the impact velocities) and will be crucial, for example, in obtaining precise coalescence kernels in such systems.
A Whole Blood Molecular Signature for Acute Myocardial Infarction
Authors: Muse Evan D. , Kramer Eric R. , Wang Haiying , Barrett Paddy , Parviz Fereshteh , Novotny Mark A. , Lasken Roger S. , Jatkoe Timothy A. , Oliveira Glenn , Peng Hongfan , Lu Jerry , Connelly Mark C. , Schilling Kurt , Rao Chandra , Torkamani Ali , Topol Eric J.
Published: September 2017

Chest pain is a leading reason patients seek medical evaluation. While assays to detect myocyte death are used to diagnose a heart attack (acute myocardial infarction, AMI), there is no biomarker to indicate an impending cardiac event. Transcriptional patterns present in circulating endothelial cells (CEC) may provide a window into the plaque rupture process and identify a proximal biomarker for AMI. Thus, we aimed to identify a transcriptomic signature of AMI present in whole blood, but derived from CECs. Candidate genes indicative of AMI were nominated from microarray of enriched CEC samples, and then verified for detectability and predictive potential via qPCR in whole blood. This signature was validated in an independent cohort. Our findings suggest that a whole blood CEC-derived molecular signature identifies patients with AMI and sets the framework to potentially identify the earlier stages of an impending cardiac event when used in concert with clinical history and other diagnostics where conventional biomarkers indicative of myonecrosis remain undetected.
Neurons define non-myelinated axon segments by the regulation of galectin-4-containing axon membrane domains
Authors: Díez-Revuelta Natalia , Higuero Alonso M. , Velasco Silvia , Peñas-de-la-Iglesia María , Gabius Hans-Joachim , Abad-Rodríguez José
Published: September 2017

The mechanism underlying selective myelination of axons versus dendrites or neuronal somata relies on the expression of somatodendritic membrane myelination inhibitors (i.e. JAM2). However, axons still present long unmyelinated segments proposed to contribute to axonal plasticity and higher order brain functions. Why these segments remain unmyelinated is still an unresolved issue. The bifunctional lectin galectin-4 (Gal-4) organizes the transport of axon glycoproteins by binding to N-acetyllactosamine (LacNac) termini of N-glycans. We have shown that Gal-4 is sorted to segmental domains (G4Ds) along the axon surface, reminiscent of these long unmyelinated axon segments in cortical neurons. We report here that oligodendrocytes (OLGs) do not deposit myelin on Gal-4 covered surfaces or myelinate axonal G4Ds. In addition, Gal-4 interacts and co-localizes in G4Ds with contactin-1, a marker of another type of non-myelinated segments, the nodes of Ranvier. Neither Gal-4 expression nor G4D dimensions are affected by myelin extracts or myelinating OLGs, but are reduced with neuron maturation. As in vitro, Gal-4 is consistently segregated from myelinated structures in the brain. Our data shape the novel concept that neurons establish axon membrane domains expressing Gal-4, the first inhibitor of myelination identified in axons, whose regulated boundaries delineate myelination-incompetent axon segments along development.
Achieving Radiation Tolerance through Non-Equilibrium Grain Boundary Structures
Authors: Vetterick Gregory A. , Gruber Jacob , Suri Pranav K. , Baldwin Jon K. , Kirk Marquis A. , Baldo Pete , Wang Yong Q. , Misra Amit , Tucker Garritt J. , Taheri Mitra L.
Published: September 2017

Many methods used to produce nanocrystalline (NC) materials leave behind non-equilibrium grain boundaries (GBs) containing excess free volume and higher energy than their equilibrium counterparts with identical 5 degrees of freedom. Since non-equilibrium GBs have increased amounts of both strain and free volume, these boundaries may act as more efficient sinks for the excess interstitials and vacancies produced in a material under irradiation as compared to equilibrium GBs. The relative sink strengths of equilibrium and non-equilibrium GBs were explored by comparing the behavior of annealed (equilibrium) and as-deposited (non-equilibrium) NC iron films on irradiation. These results were coupled with atomistic simulations to better reveal the underlying processes occurring on timescales too short to capture using in situ TEM. After irradiation, NC iron with non-equilibrium GBs contains both a smaller number density of defect clusters and a smaller average defect cluster size. Simulations showed that excess free volume contribute to a decreased survival rate of point defects in cascades occurring adjacent to the GB and that these boundaries undergo less dramatic changes in structure upon irradiation. These results suggest that non-equilibrium GBs act as more efficient sinks for defects and could be utilized to create more radiation tolerant materials in future.
Pristine populations of habitat-forming gorgonian species on the Antarctic continental shelf
Authors: Ambroso Stefano , Salazar Janire , Zapata-Guardiola Rebeca , Federwisch Luisa , Richter Claudio , Gili Josep Maria , Teixidó Nuria
Published: September 2017

Declines in the abundance of long-lived and habitat-forming species on continental shelves have attracted particular attention given their importance to ecosystem structure and function of marine habitats. The study of undisturbed habitats defined as “pristine areas” is essential in creating a frame of reference for natural habitats free of human interference. Gorgonian species are one of the key structure-forming taxa in benthic communities on the Antarctic continental shelf. Current knowledge of the diversity, distribution and demography of this group is relatively limited in Antarctica. To overcome this lack of information we present original data on pristine and remote populations of gorgonians from the Weddell Sea, some of which display the largest colony sizes ever recorded in Antarctica. We assessed the distribution patterns of seven gorgonian species, a morphogroup and a family in front of the Filchner Ronne Ice Shelf (Weddell Sea) by means of quantitative analysis of video transects. Analysis of these videos showed a total of 3140 colonies of gorgonians with the highest abundance in the southern section and a significantly clumped distribution. This study contributes to the general knowledge of pristine areas of the continental shelf and identifies the eastern Weddell Sea as a hotspot for habitat-forming species.
A multiple biomarker assay for quality assessment of botanical drugs using a versatile microfluidic chip
Authors: Li Zhen-Hao , Ai Ni , Yu Lawrence X. , Qian Zhong-Zhi , Cheng Yi-Yu
Published: September 2017

Quality control is critical for ensuring the safety and effectiveness of drugs. Current quality control method for botanical drugs is mainly based on chemical testing. However, chemical testing alone may not be sufficient as it may not capture all constituents of botanical drugs. Therefore, it is necessary to establish a bioassay correlating with the drug’s known mechanism of action to ensure its potency and activity. Herein we developed a multiple biomarker assay to assess the quality of botanicals using microfluidics, where enzyme inhibition was employed to indicate the drug’s activity and thereby evaluate biological consistency. This approach was exemplified on QiShenYiQi Pills using thrombin and angiotensin converting enzyme as “quality biomarkers”. Our results demonstrated that there existed variations in potency across different batches of the intermediates and preparations. Compared with chromatographic fingerprinting, the bioassay provided better discrimination ability for some abnormal samples. Moreover, the chip could function as “affinity chromatography” to identify bioactive phytochemicals bound to the enzymes. This work proposed a multiple-biomarker strategy for quality assessment of botanical drugs, while demonstrating for the first time the feasibility of microfluidics in this field.
Superhydrophilic Functionalization of Microfiltration Ceramic Membranes Enables Separation of Hydrocarbons from Frac and Produced Water
Authors: Maguire-Boyle Samuel J. , Huseman Joseph E. , Ainscough Thomas J. , Oatley-Radcliffe Darren L. , Alabdulkarem Abdullah A. , Al-Mojil Sattam Fahad , Barron Andrew R.
Published: September 2017

The environmental impact of shale oil and gas production by hydraulic fracturing (fracking) is of increasing concern. The biggest potential source of environmental contamination is flowback and produced water, which is highly contaminated with hydrocarbons, bacteria and particulates, meaning that traditional membranes are readily fouled. We show the chemical functionalisation of alumina ceramic microfiltration membranes (0.22 μm pore size) with cysteic acid creates a superhydrophilic surface, allowing for separation of hydrocarbons from frac and produced waters without fouling. The single pass rejection coefficients was >90% for all samples. The separation of hydrocarbons from water when the former have hydrodynamic diameters smaller than the pore size of the membrane is due to the zwitter ionically charged superhydrophilic pore surface. Membrane fouling is essentially eliminated, while a specific flux is obtained at a lower pressure (<2 bar) than that required achieving the same flux for the untreated membrane (4–8 bar).
A formation criterion for Order-Disorder (OD) phases of the Long-Period Stacking Order (LPSO)-type in Mg-Al-RE (Rare Earth) Ternary Systems
Authors: Kishida Kyosuke , Yokobayashi Hideyuki , Inui Haruyuki
Published: September 2017

The formation of OD (order-disorder) phases of the LPSO (long-period stacking ordered)-type in Mg-Al-RE (RE (rare earth) = Y, La, Ce, Nd, Sm, Dy, Ho, Er and Yb) ternary systems has been investigated for both as-solidified and annealed conditions. The OD phase is found to form in those systems with RE = Y, Nd, Sm, Dy, Ho and Er. The Mg-Al-RE OD phase formed is of the 18R-LPSO-type consisting of 6-layer structural blocks with the RE enrichment occurring in the four consecutive atomic layers in the structural block in the form of the Al6RE8 L12-type atomic clusters. The Mg-Al-RE OD phases are found to be stabilized by the inclusion of any atoms (either Mg, Al or RE) in the central site of the Al6RE8 L12-type atomic cluster. The occupancy ratio of the central site among Mg, Al and RE atoms varies with the RE element, so that the occupancy ratio of RE atoms increases with the increase in the atomic number of the RE element in particular for the late rare-earth elements. Based on the results obtained, a criterion based on the volume of the Al6RE8 atomic cluster is proposed to predict the formation of the Mg-Al-RE OD phases.
Oxygen Vacancy in WO3 Film-based FET with Ionic Liquid Gating
Authors: Kalhori Hossein , Coey Michael , Abdolhosseini Sarsari Ismaeil , Borisov Kiril , Porter Stephen Barry , Atcheson Gwenael , Ranjbar Mehdi , Salamati Hadi , Stamenov Plamen
Published: September 2017

Ionic liquid gating is a versatile method for inducing a metal-insulator transition in field-effect transistor device structures. The mechanism of carrier doping in metal oxide films is under debate. Ionic liquid gating of a WO3 film-based field effect transistor is discussed in this report. Flat and relatively smooth WO3 films were deposited on SrTiO3 substrates by pulsed laser deposition. Swept and constant gate voltage characteristics are measured in both argon and oxygen atmospheres. The results show a clear dependence on the oxygen pressure of the experimental chamber. Metallic behavior in the films is attributed to oxygen vacancy formation in the WO3 layer induced by the high electric field at the oxide-ionic liquid interface. The density of states of a monoclinic supercell of oxygen deficient WO3 was studied by density functional theory (DFT). Calculated W and O partial densities of states verify metallic behavior even at dilute oxygen vacancy concentrations and show the role of W and O orbitals in the conductivity.
Increased liver AGEs induce hepatic injury mediated through an OST48 pathway
Authors: Zhuang Aowen , Yap Felicia YT. , Bruce Clinton , Leung Chris , Plan Manuel R. , Sullivan Mitchell A. , Herath Chandana , McCarthy Domenica , Sourris Karly C. , Kantharidis Phillip , Coughlan Melinda T. , Febbraio Mark A. , Hodson Mark P. , Watt Matthew J. , Angus Peter , Schulz Benjamin L. , Forbes Josephine M.
Published: September 2017

The protein oligosaccharyltransferase-48 (OST48) is integral to protein N-glycosylation in the endoplasmic reticulum (ER) but is also postulated to act as a membrane localised clearance receptor for advanced glycation end-products (AGE). Hepatic ER stress and AGE accumulation are each implicated in liver injury. Hence the objective of this study was to increase the expression of OST48 and examine the effects on hepatic function and structure. Groups of 8 week old male mice (n = 10–12/group) over-expressing the gene for OST48, dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST+/−), were followed for 24 weeks, while randomised to diets either low or high in AGE content. By week 24 of the study, either increasing OST48 expression or consumption of high AGE diet impaired liver function and modestly increased hepatic fibrosis, but their combination significantly exacerbated liver injury in the absence of steatosis. DDOST+/− mice had increased both portal delivery and accumulation of hepatic AGEs leading to central adiposity, insulin secretory defects, shifted fuel usage to fatty and ketoacids, as well as hepatic glycogen accumulation causing hepatomegaly along with hepatic ER and oxidative stress. This study revealed a novel role of the OST48 and AGE axis in hepatic injury through ER stress, changes in fuel utilisation and glucose intolerance.
The neural representation of personally familiar and unfamiliar faces in the distributed system for face perception
Authors: Visconti di Oleggio Castello Matteo , Halchenko Yaroslav O. , Guntupalli J. Swaroop , Gors Jason D. , Gobbini M. Ida
Published: September 2017

Personally familiar faces are processed more robustly and efficiently than unfamiliar faces. The human face processing system comprises a core system that analyzes the visual appearance of faces and an extended system for the retrieval of person-knowledge and other nonvisual information. We applied multivariate pattern analysis to fMRI data to investigate aspects of familiarity that are shared by all familiar identities and information that distinguishes specific face identities from each other. Both identity-independent familiarity information and face identity could be decoded in an overlapping set of areas in the core and extended systems. Representational similarity analysis revealed a clear distinction between the two systems and a subdivision of the core system into ventral, dorsal and anterior components. This study provides evidence that activity in the extended system carries information about both individual identities and personal familiarity, while clarifying and extending the organization of the core system for face perception.
The public cancer radiology imaging collections of The Cancer Imaging Archive
Authors: Prior Fred , Smith Kirk , Sharma Ashish , Kirby Justin , Tarbox Lawrence , Clark Ken , Bennett William , Nolan Tracy , Freymann John
Published: September 2017

The Cancer Imaging Archive (TCIA) is the U.S. National Cancer Institute’s repository for cancer imaging and related information. TCIA contains 30.9 million radiology images representing data collected from approximately 37,568 subjects. This data is organized into collections by tumor-type with many collections also including analytic results or clinical data. TCIA staff carefully de-identify and curate all incoming collections prior to making the information available via web browser or programmatic interfaces. Each published collection within TCIA is assigned a Digital Object Identifier that references the collection. Additionally, researchers who use TCIA data may publish the subset of information used in their analysis by requesting a TCIA generated Digital Object Identifier. This data descriptor is a review of a selected subset of existing publicly available TCIA collections. It outlines the curation and publication methods employed by TCIA and makes available 15 collections of cancer imaging data.
Precision annotation of digital samples in NCBI’s gene expression omnibus
Authors: Hadley Dexter , Pan James , El-Sayed Osama , Aljabban Jihad , Aljabban Imad , Azad Tej D. , Hadied Mohamad O. , Raza Shuaib , Rayikanti Benjamin Abhishek , Chen Bin , Paik Hyojung , Aran Dvir , Spatz Jordan , Himmelstein Daniel , Panahiazar Maryam , Bhattacharya Sanchita , Sirota Marina , Musen Mark A. , Butte Atul J.
Published: September 2017

The Gene Expression Omnibus (GEO) contains more than two million digital samples from functional genomics experiments amassed over almost two decades. However, individual sample meta-data remains poorly described by unstructured free text attributes preventing its largescale reanalysis. We introduce the Search Tag Analyze Resource for GEO as a web application (http://STARGEO.org) to curate better annotations of sample phenotypes uniformly across different studies, and to use these sample annotations to define robust genomic signatures of disease pathology by meta-analysis. In this paper, we target a small group of biomedical graduate students to show rapid crowd-curation of precise sample annotations across all phenotypes, and we demonstrate the biological validity of these crowd-curated annotations for breast cancer. STARGEO.org makes GEO data findable, accessible, interoperable and reusable (i.e., FAIR) to ultimately facilitate knowledge discovery. Our work demonstrates the utility of crowd-curation and interpretation of open ‘big data’ under FAIR principles as a first step towards realizing an ideal paradigm of precision medicine.
A capped trigonal pyramidal molybdenum hydrido complex and an unusually mild sulfur–carbon bond cleavage reaction
Authors: Morris Robert H.
Published: September 2017

A five coordinate molybdenum hydride with an unprecedented CTP structure reacts with methanol, leading to the facile cleavage of a sulfur–carbon bond.
Controllable synthesis of AlN nanostructures and their photoluminescence
Authors: Shen Longhai , Lv Wei , Wang Nan , Wu Lijun , Qi Dongli , Ma Yuantai , Lei Weiwei
Published: September 2017

AlN nanostructures with controllable morphologies are synthesized on a Si substrate with an Al particle layer as a self-catalyst via a chemical vapor deposition (CVD) technique under atmospheric pressure.
BiVO4hollow microplates: controlled synthesis and enhanced photocatalytic activity achieved through one-step boron doping and Co(OH)2loading
Authors: Adenle Abraham , Ma De-Kun , Qu De-Peng , Chen Wei , Huang Shaoming
Published: September 2017

BiVO4hollow microplates co-modified by boron doping and Co(OH)2nanoparticle loading achieved enhanced photocatalytic activity.
Generic tags for Mn(ii) and Gd(iii) spin labels for distance measurements in proteins
Authors: Yang Yin , Gong Yan-Jun , Litvinov Aleksei , Liu Hong-Kai , Yang Feng , Su Xun-Cheng , Goldfarb Daniella
Published: September 2017

The coordination mode of the metal ion in the spin label affects the distance distribution determined by DEER distance measurements.
Spectroscopy of prospective interstellar ions and radicals isolated inpara-hydrogen matrices
Authors: Tsuge Masashi , Tseng Chih-Yu , Lee Yuan-Pern
Published: September 2017

Thep-H2matrix-isolation technique coupled with photolysisin situor electron bombardment produces protonated or hydrogenated species important in astrochemistry.
Tuning the confinement space of N-carbon shell-coated ruthenium nanoparticles: highly efficient electrocatalysts for hydrogen evolution reaction
Authors: Chen Xianlang , Zheng Jian , Zhong Xing , Jin Yihan , Zhuang Guilin , Li Xiaonian , Deng Shengwei , Wang Jian-guo
Published: September 2017

Development of efficient and durable catalysts for the hydrogen evolution reaction (HER) in an alkaline system is vital for the transformation of renewable energy into hydrogen fuel.
A combined docosahexaenoic acid–thyroid hormone protocol upregulates rat liver β-Klotho expression and downstream components of FGF21 signaling as a potential novel approach to metabolic stress conditions
Authors: Vargas R. , Riquelme B. , Fernández J. , Videla L. A.
Published: September 2017

We study the mechanism of how liver preconditioning by a DHA and triiodothyronine combined protocol underlies peroxisome-proliferator activated receptor α (PPARα)-fibroblast growth factor 21 (FGF21) upregulation.
Moderation of hyperuricemia in rats via consuming walnut protein hydrolysate diet and identification of new antihyperuricemic peptides
Authors: Li Qingyong , Kang Xiaoyan , Shi Chuanchao , Li Yujuan , Majumder Kaustav , Ning Zhengxiang , Ren Jiaoyan
Published: September 2017

Walnut-derived antihyperuricemic peptides were purified and identified based on decreasing serum uric acid level and inhibiting xanthine oxidase.
Development, validation and verification of an ICP-MS procedure for a multi-element analysis of uranium ore concentrates
Authors: Boulyga Sergei F. , Cunningham J. Alan , Macsik Zsuzsanna , Hiess Joe , Peńkin Maxim V. , Walsh Stephen J.
Published: September 2017

A validated procedure for SF-ICP-MS determination of 67 minor and trace elements in uranium ore concentrates applied to nuclear safeguards.
A fast, reconfigurable flow switch for paper microfluidics based on selective wetting of folded paper actuator strips
Authors: Kong Taejoon , Flanigan Shawn , Weinstein Matthew , Kalwa Upender , Legner Christopher , Pandey Santosh
Published: September 2017

In paper microfluidics, the development of smart and versatile switches is critical for the regulation of fluid flow across multiple channels.
A microfluidic trap array for longitudinal monitoring and multi-modal phenotypic analysis of individual stem cell aggregates
Authors: Jackson-Holmes E. L. , McDevitt T. C. , Lu H.
Published: September 2017

We present a microfluidic platform for culture, longitudinal tracking, and imaging-based analysis of individual stem cell aggregates.
Biomolecularly stimuli-responsive tetra-poly(ethylene glycol) that undergoes sol–gel transition in response to a target biomolecule
Authors: Norioka Chisa , Okita Kazuma , Mukada Miho , Kawamura Akifumi , Miyata Takashi
Published: September 2017

We designed biotin-conjugated four-armed poly(ethylene glycol) (biotinylated Tetra-PEG) as biomolecularly stimuli-responsive polymers that underwent the phase transition from a sol to a gel state in response to avidin as a target biomolecule.
Temperature programed photo-induced RAFT polymerization of stereo-block copolymers of poly(vinyl acetate)
Authors: Li Na , Ding Dongdong , Pan Xiangqiang , Zhang Zhengbiao , Zhu Jian , Boyer Cyrille , Zhu Xiulin
Published: September 2017

Stereo-triblock copolymers of poly(vinyl acetate) are synthesized with controlled molecular weights based on a temperature-programed photo-induced RAFT in HFIP.
A polyaniline-derived iron–nitrogen–carbon nanorod network anchored on graphene as a cost-effective air-cathode electrocatalyst for microbial fuel cells
Authors: Cao Chun , Wei Liling , Wang Gang , Liu Jianting , Zhai Qiran , Shen Jianquan
Published: September 2017

A cost-effective Fe–N–C/G, which exhibited a distinct catalytic activity in neutral medium and air-cathode MFCs, was prepared for ORR catalyst.
Mechanistic investigations and molecular properties of 1,2-bis(ferrocenyl)dimetallenes including group 14 elements
Authors: Hua Hsu-Cheng , Su Ming-Der
Published: September 2017

The theoretical results suggest the reactivity increases in the order:1-C≪1-Si<1-Ge<1-Sn<1-Pb.
Adsorption of Cu(ii) ions in aqueous solution by aminated lignin from enzymatic hydrolysis residues
Authors: Xu Jun , Zhu Shiyun , Liu Peng , Gao Wenhua , Li Jun , Mo Lihuan
Published: September 2017

Aminated lignin (AL) has been prepared by a Mannich reaction for the removal of Cu(ii) ions from aqueous solution.
Alkylthiol-enabled Se powder dissolving for phosphine-free synthesis of highly emissive, large-sized and spherical Mn-doped ZnSeS nanocrystals
Authors: Ke Bao , Bai Xianwei , Wang Rongkai , Shen Yayun , Cai Chunxiao , Bai Kun , Zeng Ruosheng , Zou Bingsuo , Chen Zhencheng
Published: September 2017

The enhanced dissolution of Se without organo-phosphines is a key issue in the synthesis of oil-soluble selenide nanocrystals.
Microstructure and sintering behavior of low temperature cofired Li4/5Mg4/5Ti7/5O4 ceramics containing BaCu(B2O5) and TiO2 and their compatibility with a silver electrode
Authors: Zhou Huanfu , Tan Xianghu , Wang Kangguo , Sun Wendong , Ruan Hong , Chen Xiuli
Published: September 2017

Li4/5Mg4/5Ti7/5O4 (LMT) ceramics were prepared via a solid-state reaction method.
Effect of strain-induced martensite on the tribocorrosion of AISI 316L austenitic stainless steel in seawater
Authors: Liu Eryong , Zhang Yingxin , Zhu Lufa , Zeng Zhixiang , Gao Ruipeng
Published: September 2017

Pin-on-disc friction experiments were carried out to investigate the tribocorrosion of AISI 316L in seawater, demonstrated that the tribocorrosion of AISI 316L was dominated by the formation and corrosion of strain-induced-martensite with austenite.
Revealing phase relations between Fe2B7and FeB4and hypothetical Fe2B7-type Ru2B7and Os2B7: first-principles calculations
Authors: Zhang Yunkun , Wan Biao , Wu Lailei , Li Zhiping , Wang Zhibin , Zhang Jingwu , Gou Huiyang , Gao Faming
Published: September 2017

Fe2B7+ B is suggested to be an alternative route to obtain hard superconducting FeB4due to the similar enthalpy.
A Zn based metal organic framework nanocomposite: synthesis, characterization and application for preconcentration of cadmium prior to its determination by FAAS
Authors: Nazari Zahra , Taher Mohammad Ali , Fazelirad Hamid
Published: September 2017

The SEM image of a synthesized metal–organic framework (MOF) with Zn and benzene-1,3-dicarboxylic acid via hydrothermal method as a selective nanoadsorbent for the preconcentration of trace amount of cadmium via SPE method and determination by FAAS.
Surface crystallization of low thermal expansion Ba0.5Sr0.5Zn2Si2O7 from an 8 BaO·8 SrO·34 ZnO·50 SiO2 glass
Authors: Kracker Michael , Vladislavova Liliya , Thieme Christian , Zscheckel Tilman , Thieme Katrin , Höche Thomas , Rüssel Christian
Published: September 2017

Thermal treatment of a glass with the composition 8 BaO·8 SrO·34 ZnO·50 SiO2 has led to the crystallization of a Ba1−xSrxZn2Si2O7 solid solution at the surface.
Synthesis and luminescence characteristics of fine-sized Ba3Si6O12N2:Eu green phosphor through spray pyrolysis using TEOS/Si3N4 mixed precursors
Authors: Min Byeong Ho , Jung Kyeong Youl
Published: September 2017

A fine-sized Ba3Si6O12N2:Eu3+ green phosphor with good luminescence and thermal quenching properties was prepared by spray pyrolysis using a mixture of TEOS and Si3N4 nanoparticles as the Si precursor.
Recyclable high-performance epoxy based on transesterification reaction
Authors: Lu Lu , Pan Jian , Li Guoqiang
Published: September 2017

A repeatedly recyclable thermoset network with strength and stiffness similar to conventional epoxy achieved healing efficiency as high as 88.1%.
Synthesis and characterization of novel stellate sea-urchin-like silver particles with extremely low density and superhydrophobicity
Authors: Sadovnikov S. I. , Gusev A. I.
Published: September 2017

For the first time, stellate sea-urchin-like silver particles with 24 to 56 rays of 30–40 μm in length are synthesized.
Hierarchical porous Ti2Nb10O29 nanospheres as superior anode materials for lithium ion storage
Authors: Xia Xinhui , Deng Shengjue , Feng Shangshen , Wu Jianbo , Tu Jiangping
Published: September 2017

Hierarchical porous Ti2Nb10O29 nanospheres prepared by a facile solvothermal method are demonstrated with superior Li-ion storage performance with high capacities and good cycling life.
Dendritic porous yolk@ordered mesoporous shell structured heterogeneous nanocatalysts with enhanced stability
Authors: Du Xin , Zhao Caixia , Luan Yi , Zhang Changbin , Jaroniec Mietek , Huang Hongwei , Zhang Xueji , Qiao Shi-Zhang
Published: September 2017

The integrated dendritic porous yolk@ordered mesoporous shell structured heterogeneous nanocatalysts exhibit enhanced stability and superior catalytic performance.
Development of a potential optical thermometric material through photoluminescence of Pr3+ in La2MgTiO6
Authors: Shi Rui , Lin Litian , Dorenbos Pieter , Liang Hongbin
Published: September 2017

Systematic research indicates that Pr3+ doped La2MgTiO6 has application potential in the highly sensitive optical thermometry field.
Design, synthesis, photophysical properties and pH-sensing application of pyrimidine-phthalimide derivatives
Authors: Yan Han , Meng Xinlei , Li Baoyan , Ge Shusheng , Lu Yun
Published: September 2017

Using molecular design of donor–π–acceptor pyrimidine-phthalimide derivatives, two new atypical AIE chromophores were synthesized and characterized using IR, 1H NMR, 13C NMR and HRMS.
Highly efficient red iridium(iii) complexes cyclometalated by 4-phenylthieno[3,2-c]quinoline ligands for phosphorescent OLEDs with external quantum efficiencies over 20%
Authors: Jiang Bei , Ning Xiaowen , Gong Shaolong , Jiang Nan , Zhong Cheng , Lu Zheng-Hong , Yang Chuluo
Published: September 2017

Three red iridium complexes with thieno[3,2-c]quinoline derivatives as the cyclometalated ligands were synthesized and characterized, and the corresponding red PhOLEDs achieved excellent performance with EQEs of up to 23%.
Eu3+-Doped glass ceramics containing NaTbF4 nanocrystals: controllable glass crystallization, Tb3+-bridged energy transfer and tunable luminescence
Authors: Li Xinyue , Chen Xiao , Yuan Shuo , Liu Shen , Wang Chao , Chen Daqin
Published: September 2017

The ET chains of (a) Tb3+ → (Tb3+)n → Q and (b) Tb3+ → (Tb3+)n → Eu3+. (c) The energy levels of Tb3+ and Eu3+ ions, the related radiative transitions and the possible ET routes. (d) Main luminescent transitions of Tb3+ and Eu3+ in the visible wavelength range.
An Approach to the Diastereoselective Synthesis of Cyclohexane-1,3-dicarboxamide Derivatives via a Pseudo Five-Component ­Reaction Based on Diketene
Authors: Talaei Bahareh , Heravi Majid , Oskooie Hossein , Rezvanian Atieh
Published: September 2017

A one-pot pseudo five-component reaction for the synthesis of 2-aryl-4-hydroxy-4-methyl-6-oxo-N
1,N
3-dialkylcyclohexane-1,3-dicarboxamide derivatives involving different primary amines, various aromatic aldehydes, and diketene in the presence of triethylamine with high yields is achieved.