bluuebunny/crossref_metadata_2025 huggingface dataset:
Anticipation, Action and Analysis: A New Methodology for Practice as Research
Authors: Campbell Lee
Published: November 2021

This paper proposes a new methodology for practice-as-research: “Anticipation, Action, and Analysis”. Critical evaluation of my performance artwork Lost for Words functions as the vehicle to describe Anticipation, Action, and Analysis and to theorise, articulate and demonstrate how slapstick can offer useful insights into the operations of the physical body in participative art performance that go beyond abstract theorisation. Scrutinising and examining slapstick’s performativity in relation to the subject of participation (Bourriaud 1998; Bishop 2006) within Performance Art, this paper concentrates discussion on my performance Lost for Words (2011) as a performance that by making use of slapstick as an extreme physical bodily interruptive process, really supports the problems and difficulties involved in participation within Performance Art. My definition of slapstick in this performance relates to undertaking a set of actions which forces participants’ bodies to interrupt how it normally behaves. The paper achieves this by addressing what happens when, as part of the structural framework of the performance, interruptive processes related to bodily incongruity and repetition (Heiser, 2008) are engineered into activities undertaken by participants engaging in physical and bodily processes. Defining the term collectivity as meaning being a member of a group of people with possibly shared experiences, interests and motivations, the paper also amplifies consideration of how the performance can be used to provide useful insights into the importance that collectivity and conviviality (Bourriaud 1998; Clayton 2007) plays within participatory processes. By way of contrast, the paper explores how the anti-social nature of Schadenfreude (Glenn 2003; Miller, 1993; Svendsen 2010 et al.) can also play its part as well as the, as argued, contradictory nature of hospitality (Derrida 2000) in examining how the performer and audience relation can be construed as host/guest.
A Review of Taylor Mac's 24-Decade History of Popular Music Marathon
Authors: Edgecomb Sean F.
Published: November 2021

This review considers Taylor Mac's 24-Decade History of Popular Music Marathon which took place at St. Ann's Warehouse in Brooklyn, New York from October 8 to October 9, 2016. Using Jacques Derrida's theory of "l'avenir," best translated as the "unexpected visitor" I analyze a variety of the components found in the performance including, queer dramaturgy, song selection, choreography, audience participation and costumes. My critical review examines the concert which pulled liberally from the American songbook, using popular music from 1776 to 2016 in an attempt to collectively exorcise the specters of the patriarchy and exonerate the oppressed in what Mac deemed a “radical faerie ritual.”
Speculative Performance Meets Immersive Learning: Lessons of Drylab2023
Authors: Jenik Adriene
Published: November 2021

Drylab2023, an experiment in “immersive learning,” was conducted from May 13-June 11, 2017. Eight participants lived for 30 days in a remote desert outpost limited to 4 gallons of water per person per day to meet all water needs (drinking, cooking, washing, hygiene, etc) while subsisting on a water-wise diet. Participants were charged to live within a “near future scenario” of water scarcity (2023); modelling how to manage a limited vital resource: fresh water. During the experiment, narrative progress could be tracked as it unfolded through online posts at drylab2023.net.

This article argues that: 1) speculative performance is a powerful form of knowledge creation that can prefigure and manifest alternate ways of living with climate change; 2) the participants, scenario, environmental stage, and audience collaboratively produced the performance; 3) through performance – an embodied form of knowledge – the participants came to understand what it means to live water-wise; and 4) the use of the speculative (the narrative frame of 2023) allowed participants to reflect on the past and present as well as imagine the future.
Sewing Pain: Using Costume To Bring The Clinical Body Forward
Authors: Malva Filipa
Published: November 2021

This article looks at how memory of pain and physical change provoked by surgery can be translated into costume design (understood as an extension of the performer’s body in action). My main question is in what way the construction of a performer’s secondary skin—bringing her wounds outward and forward through the sculpting of fabric into form, texture and color—can mediate between performer and spectator and shape her extended body. By making the performer’s embodied knowledge visible through costume, costume is used to enlarge her capacity for expression. Gesture and movement are central to a costume designer’s creative process. In the case of Anticorpos we were working also with actress Isabel Craveiro’s personal memories of body change. It was crucial that the design incorporated the performer’s verbal and sensual account of the multiple surgeries she had been subjected to over the course of 4 years. As she made these visible through action, I used them to inform the costume design which in turn allowed her to choose what to show and when. Fabric would at times constrain her body into a new shape, at other times expand her gestures.
Loneliness Among Migrants in Italy: Risks and Protectors
Authors: Cela Eralba , Barbiano di Belgiojoso Elisa
Published: November 2021

In this study we focused on migrants’ loneliness, in order to unpack risks for, and protective factors against, loneliness among migrants in Italy. Our data come from the ‘Social Condition and Integration among Foreign Citizens’ survey conducted by ISTAT during 2011–2012 on a sample of 25,000 individuals living in a household with at least one foreign-born member. Our results show that economic resources and employment protect from loneliness feelings, whereas education does not. Family and social embeddedness and satisfaction with life are protective factors, whereas discrimination, language barriers, deprived neighbourhoods and poor health are associated with a higher risk of loneliness. Gender is a key lens to consider when analysing loneliness especially in relation to fragile populations like those with a migratory background.
Consumption needs and Quality of Life: Austrian Economics and the causes of migration
Authors: Rauhut Daniel
Published: November 2021

This paper re-introduces the view on migration causes by the Austrian School of Economics. Austrian economics has not earned its fame in the field of migration, but rather on advocating libertarian economics. Nonetheless Mises outlined a migration model, which can be understood by adding some clarifications by Hayek. Given that the institutional barriers to migration raised by the state are removed, the interplay between market wages, standard wages, attachment component and cost component will determine the migration. While the attachment component relates to fundamental freedoms and to what is referred to as quality-of-life aspects today, the cost component relates to subjective consumption needs. Hitherto unexplored, this model offers new insights to the complex interplay between economic and sociological aspects determining migration drivers.
Remittances and subjective well-being: A static versus dynamic panel approach to happiness
Authors: Biyase Mduduzi , Fisher Bianca , Pretorius Marinda
Published: November 2021

Using all five waves of the National Income Dynamics Study (NIDS) panel dataset, we examine the effect of domestic remittances on the static and dynamic subjective well-being (SWB) of recipient individuals in South Africa, by using a random effects ordered probit model that accounts for individual heterogeneity. Moreover, we check the robustness of our static model results by making use of an instrumental variable for migrants’ remittances. Two major empirical findings emerge from this paper: firstly, domestic remittances are consistently found to have a positive and statistically significant impact on the happiness of recipient individuals. Moreover, this finding persists in both the static and dynamic panel models. Secondly, the coefficient on lagged SWB (derived from the dynamic model) is found to be positive and statistically significant, confirming that SWB today is significantly influenced by SWB in the past.
POLISH POLITICAL SCIENTIST ON THE ETHNIC FACTOR OF THE POST-SOVIET NATION-BUILDING IN MULTINATIONAL RUSSIAN REPUBLICS
Authors: ГАЛЛЯМОВ Рушан Рахимзянович , КУЧУМОВ Игорь Вильсович
Published: November 2021

The processes that led to the collapse of the USSR continue to affect the development of the post-Soviet space. Interest in this is maintained not only in Russian but also in foreign academic science. Purpose: to analyze a practically unknown in our country monograph by Polish researcher W. Zajonczkowski on the history of national policy and nation-building in the USSR on the example of Bashkortostan, Tatarstan and Buryatia, to reveal the author's exclusive viewpoint on the role and influence of the ethnic factor in these processes. Methods: the authors apply system analysis of the problem, diachronic study of ethno-political processes throughout several historical epochs, study of political and public personalities, comprehensive use of non-contradictory provisions of the world's leading concepts of ethnicity. Results: the achievements and shortcomings of the author's research are identified, the practical relevance of his conclusions is shown, the degree of their importance for national science is determined.
«LAW OF ARTIFICIAL INTELLIGENCE» AND ITS PLACE IN THE SYSTEM OF INFORMATION LAW
Authors: ПОЛЯКОВА Татьяна Анатольевна , КАМАЛОВА Гульфия Гафиятовна
Published: November 2021

The paper is devoted to contemporary problems of legal support for the development, introduction and use of artificial intelligence and robotics systems as one of the vectors of the development of Russian information law. The purpose of the study is to The aim of the study is to gain scientific insight into the place of a set of legal norms governing relations associated with this digital technology in the system of modern Russian law. In the course of the study, a group of interrelated methods is used, the choice of which is determined by the subject of scientific work, including system analysis, generalization, and the formal-logical method. As a result of the study, it is concluded that at present there are objective conditions and the need to establish a complex legal institution – the law of artificial intelligence in the information law system. The paper substantiates the complex nature of this institution and notes that the law of artificial intelligence, being a complex formation, is associated with a group of legal institutions of information law – institutions of personal data, information of limited access, Internet law, identification, responsibility in the information sphere and others.
ON CERTAIN LEGAL AND ORGANIZATIONAL ASPECTS OF PUBLIC PROCUREMENT IN RUSSIA
Authors: ГОРОХОВА Светлана Сергеевна
Published: November 2021

The paper is devoted to the analysis of certain organizational and legal aspects of the regulation of the contract system in the field of procurement for state and municipal needs. The purpose of the study is to identify legal and enforcement issues that impede the effective implementation of public procurement procedures in the Russian Federation. In order to achieve this purpose, the author uses a dialectic approach, applying a whole range of general and specific scientific methods, with a special focus on topical statistics. Results: the conclusion is drawn about the instability of the procurement law, its procedural bias, the unresolved issue of determining the initial (maximum) contract price, monopolization of procurement of small quantities of SET (single trade aggregate). It is concluded that there is a need to review approaches to determining the effectiveness of procurement procedures and to increase the responsibility of customers in this area.
CONSTITUTIONAL (STATUTORY) COUNCILS ATTACHED TO THE PARLIAMENTS IN THE CONSTITUENT ENTITIES OF THE RUSSIAN FEDERATION: TO BE OR NOT TO BE?
Authors: МУРАТШИН Фларит Рашитович
Published: November 2021

The paper explains the reasons for the centralized decision taken at the federal legislative level to abolish constitutional (statutory) courts in the constituent entities of the Russian Federation and to replace them with constitutional (statutory) councils attached to regional parliaments. The comparative analysis of the powers of the above-mentioned constitutional control bodies is carried out based on national and foreign expertise. The author suggests his own concept of constitutional (statutory) councils attached to regional Parliaments instead of constitutional (statutory) courts in the constituent entities of the Russian Federation. Purpose: to formulate conceptual framework and science-based recommendations for the formation in the constituent entities of the Russian Federation new constitutional control bodies – constitutional (statutory) councils attached to regional Parliaments. Methods: the author uses theoretical methods of formal and dialectical logic, historical methods, comparative methods, axiological methods. Results: the author concludes that the centralized replacement of the constitutional (statutory) courts in the constituent entities of the Russian Federation with constitutional (statutory) councils attached to regional Parliaments can be justified if the reorganization is carried out in a planned manner, consistently, with active cooperation with the federal authorities.
Electronic terminological dictionaries published by the Russian National Public Library for Science and Technology and plans for the future
Authors:   Russian National Public Library for Science and Technology, Moscow, Russia, Zaitseva Ekaterina , Smirnov Yury ,   Russian National Public Library for Science and Technology, Moscow, Russia
Published: November 2021

Russian National Public Library for Science and Technology publishes electronic terminological dictionaries. The history of this activity line and the publications are discussed, e. g.: The English-Russian Dictionary in Machine-readable Cataloguing, SIBID Electronic Terminological Dictionary (1-st and 2-nd editions), and Electronic Dictionary of Standardized Abbreviations in the Russian and 25 Foreign European Languages for Bibliographic Records. Links to purchase the dictionaries are given. Plans for the future are discussed. The paper is prepared within the framework of the State Order to RNPLS&T for 2021 No. 730000F.99.1.BV09АА00006.
Immersive technologies in Yugra libraries
Authors:   Yugra State Library, Khanty-Mansiysk, Russia, Kim Yulia , Fink Evgenia ,   Yugra State Library, Khanty-Mansiysk, Russia
Published: November 2021

The experience of Yugra State Library and municipal libraries of Khanty-Mansi Autonomous District in applying immersive technologies is discussed. The immersive technologies are classified by form as implemented in Yugra public libraries. The most interesting practices are characterized. The conclusion is made that implementation of immersive technologies is a natural result of library evolution and a new platform for providing user services.
Scientific and methodological heritage of the Russian National Public Library for Science and Technology: The background
Authors:   Russian National Public Library for Science and Technology, Moscow, Russia, Moseeva Darya
Published: November 2021

Being the all-Union coordination center for bibliography in technologies and the methodological center for USSR’s scientific and special libraries, the State Public Scientific and Technical Library of the USSR issued reference bibliographic publications, special periodicals, serials and manuals based on the research accomplished by the Library. It developed the system of learning materials in every area of library services and functions (user services, collection development and organization, reference aids, bibliographic work, etc.). All materials were highly demanded by scientific and technical libraries of the country and were of great importance for the advance of scientific, technical and special libraries and national librarianship on the whole. The author reviews the key reference bibliographic and methodological materials produced by the State Public Scientific and Technical Library of the USSR in 1958–1980.
The E-dictionary of Standardized Abbreviations in the Russian and 25 foreign European Languages for Bibliographic Records: The database structure and user interface
Authors:   Russian National Public Library for Science and Technology, Moscow, Russia, Smirnov Yury
Published: November 2021

The Russian National Public Library for Science and Technology has published the Electronic Dictionary of Standardized Abbreviations in the Russian and 25 Foreign European Languages for Bibliographic Records. Its structure, databases and user interface, functionality and purpose are characterized in brief. Link to purchase the dictionary is given.
The State Rubricator of Scientific and Technical Information as the backbone classification of the national system of sci-tech information: The status, problems and tasks. SRSTI Version 2021
Authors:   Russian National Public Library for Science and Technology, Moscow, Russia, Smyslova Irina , Smirnova Olga ,   Russian National Public Library for Science and Technology, Moscow, Russia
Published: November 2021

The current issues of subject systematization and indexing based on the backbone classification system, i. e. State Rubricator of Scientific and Technical Information (SRSTI), are examined. SRSTI main tasks and functions are defined. Comprehensive coverage of academic and technological knowledge, comparatively low structuring and cemental division into classes make its characteristic features. The structure of its subject vertices levels is analyzed. The main problems of upgrading SRSTI as the system of subject indexing of knowledge domains to reflect the status and priorities in science, technologies and engineering are formulated. Within the framework of designing SRSTI master version, the amendments for 2007–2020 approved by the Methodological Board for STI Classification Systems, are systematized. Both digital and printed version of current SRSTI version are produced.
Current problems of developing rare book collection at sci-tech library (case study of Central Scientific Agricultural Library)
Authors:   Central Scientific Agricultural Library, Moscow, Russia, Bunin Mikhail
Published: November 2021

The issues of methodological approaches toward and criteria of publication selection for rare and valuable book collections of sci-tech libraries are discussed. Based on the experience of CSAL, the need for comprehensive evaluation of books is substantiated: by materials and facilities, level of performance, physical condition and age, circulation, periodicity, and by value in scientific and sociocultural aspects.
Ecology and sustainable development issues in RF and the US libraries: On comparative analysis of subject digital resources
Authors:   Russian National Public Library for Science and Technology, Moscow, Russia, Bychkova Elena , Zverevich Victor ,   Russian National Public Library for Science and Technology, Moscow, Russia
Published: November 2021

The UN Sustainable Development Goals (SDGs) are reviewed from the point of view of libraries. Both Russian and American professional publications cover the issues within their ecological education (EE) and sustainable development education activities which enables to compare them in many aspects. Key groups of relevant sources are determined: publications in professional periodicals, analytical materials on the web-sites of libraries and associations, resources on libraries’ websites, social media, and blogs. Each group of resources is analyzed. The conclusion is made that relevant information sources reflecting similar segments of library activities can be necessarily and possibly determined for further studies.
Semantic matching of State Rubricator of Sci-tech Information and OECD headings
Authors:   Russian National Public Library for Science and Technology, Moscow, Russia, Dmitrieva Elena , Terekhova Elena ,   Russian National Public Library for Science and Technology, Moscow, Russia
Published: November 2021

The study was completed to solve the problems of information compatibility and integration of subject subspaces into the single one and information retrieval from heterogeneous resources classified within different classifications of sci-tech information. Based on intellectual analysis and classification synonymity achieved through semantic mapping of hierarchy branches, the tables of SRSTI-OECD headings interreflection were designed. The mapping tables are supplemented with indices comprising Russian-English and English-Russian keywords and word combinations to classify OECD subject domains. The statistics of defined semantic matches distribution of classification numbers in SRSTI thematical classes is included. The SRSTI-OECD «adapter» (semantic links between the classifications and two-language subject indices) makes the component of the single network of interrelated classification systems being developed at the Russian National Public Library for Science and Technology
Respostas inflamatórias agudas ao treinamento de flexibilidade: uma revisão sistemática
Authors: Nogueira Carlos José , Garcia Andrea Dos Santos , Souza Isabelle Vasconcelos de , Cortez Antônio Carlos Leal , Senna Gilmar Weber , Brandão Paula Paraguassu , Henrique Martin Dantas Estélio
Published: November 2021

Objetivo: O objetivo do estudo foi avaliar sistematicamente as evidências científicas disponíveis sobre a eficácia e segurança do treinamento de flexibilidade em diferentes intensidades sobre as respostas inflamatórias agudas em homens adultos. Métodos: Foi realizada uma busca nas bases de dados Medline/PubMed, Cochrane Library, Web of Science e Scopus e uma busca manual nas listas de referências de estudos relevantes. A questão de pesquisa e a estratégia utilizadas foram baseadas no modelo PICO. Foram incluídos estudos envolvendo adultos com idade entre 18 e 45 anos, publicados nos idiomas inglês, espanhol e português, sem restrição de ano de publicação. Resultados: Um total de 1.014 artigos foram recuperados inicialmente. Após a eliminação das duplicatas, foram analisadas 655 referências por título e resumo, das quais 16 foram incluídas para leitura na íntegra. Após essa etapa, 13 referências foram excluídas. Ao final, 3 estudos foram considerados elegíveis. Conclusão: As evidências disponíveis sugerem que exercícios de alongamento máximo em combinação com exercícios excêntricos não habituais ou aplicados isoladamente estão associados a uma possível resposta inflamatória aguda. Com base nas evidências e na qualidade dos artigos incluídos nesta revisão, os resultados devem ser interpretados com cautela. Pesquisas futuras com melhor qualidade metodológica envolvendo as variáveis ​​estudadas podem explicar melhor os resultados obtidos até o momento.
BBLR, Pemberian ASI Eksklusif, Pendapatan Keluarga, dan Penyakit Infeksi Berhubungan dengan Kejadian Stunting
Authors: Saadong Djuhadiah , B Suriani , Nurjaya Nurjaya , Subriah Subriah
Published: November 2021

Stunting is a nutritional problem that hinders the growth process of toddlers. Toddler stunting has a negative impact that will last in the next life. According to UNICEF (2011), the nutritional status of children can be directly affected by factors, namely gender and low birth weight. Indirect factors, namely health status, infectious diseases/ Acute Respiratory Infections (ARI), diarrhea with low family income, parenting patterns, and not exclusive breastfeeding. The aim of the study was to investigate the relationship between low birth weight, exclusive breastfeeding, family income, and infectious diseases with the incidence of stunting in toddlers aged 24-59 months in the Mangasa Health Center Work Area in 2020. This was a case control study involving a total of 30 stunted and non-stunded children in each. The independent variables were low birth weight breastfeeding exclusive, family income, and infectious diseases, while the dependent variable is stunting. The study results show that children with low birth weight were like to have stunting 5.7 times than normal birth weight (p=0.007). Similarly, children with formula and mixed feeding were likely to have stunting 5 times (p=0.015) than exclusively breastfed children. Poor family income and the presence of infectious disease were also contributed to stunting (OR= 7; p= 0.025, OR= 5.7, p= 0.007, respectively). In conclusion, the family income variable is the variable that has the most incidence of stunting among children aged 24 – 59 months.
Knowledge Integration and Disruptive Innovation Product Development: Case Studies of Company A
Authors: Tsai Wen-Chun , Su Yi-Han
Published: November 2021

Because of the energy crisis, companies started developing electric vehicles. Company A, as a new entrant, successfully developed a disruptive innovation of the world’s first high-performance, zero emissions, and two-wheeled electric scooter. As disruptive innovation is frequently discovered in the combination of different industrial technologies, company A is comprised of high-tech and traditional industry resources and knowledge. This study aims to explore the process of heterogeneous industry knowledge integration in the traditional motorcycle manufacturing industry by a case study of company A. Following qualitative research method, this study concludes four main findings in product development: (1) organizational knowledge integration is identified to mitigate the impact of functional conflict; (2) design validation knowledge integration is identified to set the standard for pioneer product strategy; (3) internal and external engineering knowledge integration is identified to realizes the goal of pioneer product strategy; (4) product validation knowledge integration is identified to coordinate the flexible planning process.
La Critique et le dépassement de la « méthode expérimentale » dans Thérèse Raquin
Authors: Sicard-Cowan Hélène
Published: November 2021

This article makes the case for reading Zola’s protagonists Laurent and Thérèse as literary foils for one of the founding fathers of the experimental method, namely the physiologist Claude Bernard, and his wife, Fanny Martin. Drawing more particularly on elements from Bernard’s and Martin’s lives, as well as Bernard’s scientific writings, the article shows that Zola ‘performs’ two grueling experiments in the aforementioned novel: the first one, initiated by the author himself, results in the death of three protagonists and the paralysis of the fourth one; the second experiment, initiated by Laurent, reveals that the latter’s evaluation of Thérèse and his ensuing hypothesis are seriously flawed. In fact, Laurent’s gaze is marred by his tendency to ‘dirty’ nature (‘salir la nature,’ to borrow Zola’s expression), and his experiment doesn’t turn out the way he had originally planned, as both lovers turned murderers end up committing suicide together. This article thus argues that, in Thérèse Raquin, Zola resorts to critical posturing as a vivisector in a text that can be read as a revenge narrative which gestures towards the possibility for vivisectors to be ‘redeemed’ as individuals made fully capable of feeling compassion for their objects through angelic intervention.
Women’s Entrepreneurship in Turkey: Recent Patterns and Practices | Türkiye’de Girişimci Kadınlar: Güncel Örüntüler ve Pratikler
Authors: E. MERT Aslı
Published: November 2021

This article sets out to understand the recent patterns and practices of women’s entrepreneurship in Turkey, and by investigating its demographics using quantitative methods, critically discussing microcredit as a policy tool, evaluating the reinforcement provided by civil society and public institutions specifically based on the action plans of the Small and Medium Enterprises Development Organization (KOSGEB), the aim is to examine whether existing entrepreneurship opportunities and support mechanisms enhance women’s skills and potential based on Nussbaum’s (1999; 2000) combined capabilities approach and human powers concept. This article finds that there is no particularly restricted demographics of women’s entrepreneurship in Turkey, specifically referring to marital status and educational level. In terms of microcredit as a common practice, discussions underline that it does not seem to contribute to women’s human powers to a large extent in terms of strengthening their position in the job market and society. Finally, it is seen that there are various sources of support towards women in entrepreneurship in Turkey offered largely by NGOs as well as public institutions, yet at the level of action plans the main target is mostly increasing the number of entrepreneur women, who are considered as a part of special target groups rather than being regarded as a separate focus. Based on Nussbaum’s combined capabilities approach (1999), this article underlines that public institutions and social policies as primary external capabilities need to continue supporting women’s internal capabilities (via training, networking activities etc.) in entrepreneurship, yet also concurrently focus on the expansion of the scope and fields of women-owned businesses to enable the execution of their human powers.
The Effect of Recitation Method on Learning Outcomes of “Life Events” of 5th Grade
Authors: Ilyas Habibulloh Muhammad , Nuruddin Muhammad
Published: November 2021

This study aims as a way to determine the effect of the recitation method on learning outcomes of events in life that focuses on sub-theme 2 national events about the proclamation of independence day at SDN Gongseng 1 Jombang. As we know that the average learning process in schools is still centered on the teacher himself. By using the right application, it is certain that it will have a good impact on the quality of education. The lack of student interest in the methods taught by the teacher had a significant impact. In the process of working on questions, for example, students are less able to understand what is conveyed by the teacher who is able to provide a learning process whose substance is carried out by selecting the appropriate method. This research is pre-experimental research design, in the form of one-group pretest-posttest. The sample of this study consisted of 9 boys and 10 girls totaling 19 students who were in the experimental class. In the academic year 2021, it can be seen that the results of the pretest and posttest data of students by using the recitation method have sig. 0.000 < 0.05. From these results, it can be concluded that the effect of recitation has an influence on classroom learning by using conventional methods.
Development of Media Fun Thinkers Book Material for The Diversity of Living Things for Class IV Elementary School
Authors: Nur Anggraini Pipin , Asmarani Ratih
Published: November 2021

In the implementation of learning activities that occur at SD Plus Pesantren Al-Anwar, problems when implementing learning activities, among others, are the media used are not supportive, teachers use learning resources in the form of books and have not used certain learning media. This is the cause of students tend to be passive in learning activities. When learning theme 3 sub-theme 2 learning 2 in class IV the teacher uses image media in teaching and learning activities, making students less understanding of the material. As a result, students are less interested in teaching and learning activities. This research was conducted in class IV, which consisted of 20 students. In the development research that has been carried out, it is expected to be able to provide a good influence for students, the Fun Thinkers book media is to foster student learning activities and achievements and must use media that can foster student interest in learning so that they are enthusiastic in undergoing the learning process. Research using the ADDIE model which passes through 5 stages.
The Effect of Interactive Multimedia on Critical Thinking in Social Studies Learning for Grade V in Elementary Schools
Authors: Irmawati Leni , Fitra Raharja Hawwin
Published: November 2021

Education is the most important factor in determining one's future. With education, it can help humans to think about following developments in the modern era as it is today. It is the same as helping students think critically. As happened at SDN Kaliwungu 2 Jombang, teaching and learning activities that do not use media make students feel bored when studying and find it difficult to improve students' critical thinking. The purpose of this study was to determine the effect of interactive multimedia on students' critical thinking on the material of human interaction with the environment and its effect on social development in fifth grade elementary school. This type of research is a quantitative experiment through a one group pre test post test design. The population of the study were all students of class V SDN Kaliwungu 2 Jombang, which amounted to 20 students, according to the results of data analysis showing that the lowest pretest score was 32 and the highest score was 88 with an average of 61.20 while the lowest posttest score was 56 and the highest score was 92 with an average of 75.80, based on calculations showed an increase after learning to use interactive multimedia. These results indicate that there is an influence on the creativity of critical thinking in social studies learning in class V at the elementary school level.
Logical Paradoxes in Non-Classical Logic Systems
Authors: Dolgikh Serge
Published: November 2021

It is shown that well-known logical paradoxes such as Barber paradox can be interpreted differently in non-classical logic systems such as multi-valued, continuous and quantum logic with possibility of solutions of the paradox. The results of this research can have applications in investigations of completeness of logic systems.
Revealing the Enhancement and Degradation Mechanisms Affecting the Performance of Carbonate Precipitation in EICP Process
Authors: Hu Wenle , Cheng Wen-Chieh , Wen Shaojie , Yuan Ke
Published: November 2021

Given that acid-rich rainfall can cause serious damage to heritage buildings in NW China and subsequently accelerate their aging problem, countermeasures to protect their integrity and also to preserve the continuity of Chinese culture are in pressing need. Enzyme-induced carbonate precipitation (EICP) that modifies the mechanical properties of the soil through enhancing the interparticle bonds by the precipitated crystals and the formation of other carbonate minerals is under a spotlight in recent years. EICP is considered as an alternative to the microbial-induced carbonate precipitation (MICP) because cultivating soil microbes are considered to be challenging in field applications. This study conducts a series of test tube experiments to reproduce the ordinary EICP process, and the produced carbonate precipitation is compared with that of the modified EICP process subjected to the effect of higher MgCl2, NH4Cl, and CaCl2 concentrations, respectively. The modified EICP, subjected to the effect of higher MgCl2 concentrations, performs the best with the highest carbonate precipitation. The enhancement mechanism of carbonate precipitation is well interpreted through elevating the activity of urease enzyme by introducing the magnesium ions. Furthermore, the degradation of carbonate precipitation presents when subjected to the effect of higher NH4Cl concentration. The decreasing activity of urease enzyme and the reverse EICP process play a leading role in degrading the carbonate precipitation. Moreover, when subjected to the effect of higher CaCl2 concentrations, the slower rate of urea hydrolysis and the decreasing activity of urease enzyme are primarily responsible for forming the “hijacking” phenomenon of carbonate precipitation. The findings of this study explore the potential use of the EICP technology for the protection of heritage buildings in NW China.
Dynamic Spatial Tuning Patterns of Shoulder Muscles with Volunteers in a Driving Posture
Authors: Fice Jason B. , Larsson Emma , Davidsson Johan
Published: November 2021

Computational human body models (HBMs) of drivers for pre-crash simulations need active shoulder muscle control, and volunteer data are lacking. The goal of this paper was to build shoulder muscle dynamic spatial tuning patterns, with a secondary focus to present shoulder kinematic evaluation data. 8M and 9F volunteers sat in a driver posture, with their torso restrained, and were exposed to upper arm dynamic perturbations in eight directions perpendicular to the humerus. A dropping 8-kg weight connected to the elbow through pulleys applied the loads; the exact timing and direction were unknown. Activity in 11 shoulder muscles was measured using surface electrodes, and upper arm kinematics were measured with three cameras. We found directionally specific muscle activity and presented dynamic spatial tuning patterns for each muscle separated by sex. The preferred directions, i.e. the vector mean of a spatial tuning pattern, were similar between males and females, with the largest difference of 31° in the pectoralis major muscle. Males and females had similar elbow displacements. The maxima of elbow displacements in the loading plane for males was 189 ± 36 mm during flexion loading, and for females, it was 196 ± 36 mm during adduction loading. The data presented here can be used to design shoulder muscle controllers for HBMs and evaluate the performance of shoulder models.
Bioclickable Mussel-Derived Peptides With Immunoregulation for Osseointegration of PEEK
Authors: Zhao Huan , Wang Xiaokang , Zhang Wen , Wang Lin , Zhu Can , Huang Yingkang , Chen Rongrong , Chen Xu , Wang Miao , Pan Guoqing , Shi Qin , Zhou Xichao
Published: November 2021

Polyether ether ketone (PEEK)–based biomaterials have been widely used in the field of spine and joint surgery. However, lack of biological activity limits their further clinical application. In this study, we synthesized a bioclickable mussel-derived peptide Azide-DOPA4 as a PEEK surface coating modifier and further combined bone morphogenetic protein 2 functional peptides (BMP2p) with a dibenzylcyclooctyne (DBCO) motif through bio-orthogonal reactions to obtain DOPA4@BMP2p-PEEK. As expected, more BMP2p can be conjugated on PEEK after Azide-DOPA4 coating. The surface roughness and hydrophilicity of DOPA4@BMP2p-PEEK were obviously increased. Then, we optimized the osteogenic capacity of PEEK substrates. In vitro, compared with the BMP2p-coating PEEK material, DOPA4@BMP2p-PEEK showed significantly higher osteogenic induction capability of rat bone marrow mesenchymal stem cells. In vivo, we constructed a rat calvarial bone defect model and implanted PEEK materials with a differently modified surface. Micro-computed tomography scanning displayed that the DOPA4@BMP2p-PEEK implant group had significantly higher new bone volume and bone mineral density than the BMP2p-PEEK group. Histological staining of hard tissue further confirmed that the DOPA4@BMP2p-PEEK group revealed a better osseointegrative effect than the BMP2p-PEEK group. More importantly, we also found that DOPA4@BMP2p coating has a synergistic effect with induced Foxp3+ regulatory T (iTreg) cells to promote osteogenesis. In summary, with an easy-to-perform, two-step surface bioengineering approach, the DOPA4@BMP2p-PEEK material reported here displayed excellent biocompatibility and osteogenic functions. It will, moreover, offer insights to engineering surfaces of orthopedic implants.
Computational Modelling and Big Data Analysis of Flow and Drug Transport in Microfluidic Systems: A Spheroid-on-a-Chip Study
Authors: Kheiri Sina , Kumacheva Eugenia , Young Edmond W.K.
Published: November 2021

Microfluidic tumour spheroid-on-a-chip platforms enable control of spheroid size and their microenvironment and offer the capability of high-throughput drug screening, but drug supply to spheroids is a complex process that depends on a combination of mechanical, biochemical, and biophysical factors. To account for these coupled effects, many microfluidic device designs and operating conditions must be considered and optimized in a time- and labour-intensive trial-and-error process. Computational modelling facilitates a systematic exploration of a large design parameter space via in silico simulations, but the majority of in silico models apply only a small set of conditions or parametric levels. Novel approaches to computational modelling are needed to explore large parameter spaces and accelerate the optimization of spheroid-on-a-chip and other organ-on-a-chip designs. Here, we report an efficient computational approach for simulating fluid flow and transport of drugs in a high-throughput arrayed cancer spheroid-on-a-chip platform. Our strategy combines four key factors: i) governing physical equations; ii) parametric sweeping; iii) parallel computing; and iv) extensive dataset analysis, thereby enabling a complete “full-factorial” exploration of the design parameter space in combinatorial fashion. The simulations were conducted in a time-efficient manner without requiring massive computational time. As a case study, we simulated >15,000 microfluidic device designs and flow conditions for a representative multicellular spheroids-on-a-chip arrayed device, thus acquiring a single dataset consisting of ∼10 billion datapoints in ∼95 GBs. To validate our computational model, we performed physical experiments in a representative spheroid-on-a-chip device that showed excellent agreement between experimental and simulated data. This study offers a computational strategy to accelerate the optimization of microfluidic device designs and provide insight on the flow and drug transport in spheroid-on-a-chip and other biomicrofluidic platforms.
Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy
Authors: Hu Tingting , Qin Zhou , Shen Chao , Gong Han-Lin , He Zhi-Yao
Published: November 2021

Mitochondria, a kind of subcellular organelle, play crucial roles in cancer cells as an energy source and as a generator of reactive substrates, which concern the generation, proliferation, drug resistance, and other functions of cancer. Therefore, precise delivery of anticancer agents to mitochondria can be a novel strategy for enhanced cancer treatment. Mitochondria have a four-layer structure with a high negative potential, which thereby prevents many molecules from reaching the mitochondria. Luckily, the advances in nanosystems have provided enormous hope to overcome this challenge. These nanosystems include liposomes, nanoparticles, and nanomicelles. Here, we summarize the very latest developments in mitochondria-targeting nanomedicines in cancer treatment as well as focus on designing multifunctional mitochondria-targeting nanosystems based on the latest nanotechnology.
Organizational Building Blocks for Blockchain Governance: A Survey of 241 Blockchain White Papers
Authors: Honkanen Petri , Nylund Mats , Westerlund Magnus
Published: November 2021

Governance for centralized organizational structures has long roots and well-developed frameworks, including for various specialty areas, such as IT or data governance. However, the introduction of blockchain technology as a supportive tool for implementing decentralized organizations requires a renewed focus for research in the area. The paper utilizes empirical data from blockchain ecosystems in the form of white papers (public communique of intention) to analyze their governance intentions. The empirical findings are based on a review of 241 blockchains and distributed ledger technology white papers, out of which 67 include explicit descriptions of how governance should be organized in the ecosystem. Our empirical research distinguishes between three categories of governance: objectives, mechanisms, and stakeholders. We further identify 28 features for these categories, which are described in an open encoding format. Hence, the paper contributes to the emerging blockchain research field, particularly to the decentralized aspects of blockchain governance research. This research also reveals that blockchain governance does not receive the attention it should as a large majority of ecosystems have not disclosed their governance intentions. The results can be utilized as a framework for future research. The results can also be helpful for industry when designing and developing governance systems.
Hypoxia-Induced ZWINT Mediates Pancreatic Cancer Proliferation by Interacting With p53/p21
Authors: Chen Peng , He Zhiwei , Wang Jie , Xu Jian , Jiang Xueyi , Chen Yankun , Liu Xinyuan , Jiang Jianxin
Published: November 2021

p53/p21 signaling plays a vital role in pancreatic cancer (PC) progression. ZWINT was shown to function as an oncoprotein in the progression of multiple cancers. However, the involvement of ZWINT and p53 activation in the progression of PC remains poorly understood. Bioinformatics and tissue array chip analyses were performed to evaluate ZWINT expression in pancreatic cancer. ZWINT mRNA and protein expression were evaluated in normoxia and hypoxia. CHIP was used to evaluate HIF1α interaction with the ZWINT promoter. CCK8, colony formation, EDU, and cell cycle analysis were used to examine PC cell proliferation. Immunoprecipitation and immunofluorescence were used to examine the interaction of ZWINT, MDM2, and p53. p53 activity was evaluated by q-PCR and luciferase assay. Protein degradation and ubiquitination assays were used to analyze the role of ZWINT in p53 ubiquitination. ZWINT was overexpressed in pancreatic cancer and induced in hypoxia. ZWINT promoted pancreatic cancer growth and cell cycle progression. Bioinformatic analysis revealed that ZWINT may regulate the p53 signal pathway. ZWINT interacts with p53 and promotes its ubiquitination and degradation. ZWINT promoted proliferation via p53/p21. Immunohistochemistry of clinical specimens revealed that that ZWINT expression was significantly negatively correlated with p53/p21. Our data showed that hypoxia regulates the expression of ZWINT, which activated p53/p21 signaling pathway to promote PC growth.
ADAMTS9-AS1 Constrains Breast Cancer Cell Invasion and Proliferation via Sequestering miR-301b-3p
Authors: Chen Junqing , Cheng Ling , Zou Weibin , Wang Rong , Wang Xiaojia , Chen Zhanhong
Published: November 2021

Objective: For determination of how ADAMTS9-AS1/miR-301b-3p/TGFBR2/JAK STAT signaling axis modulates progression of breast cancer cells.

Methods: Target lncRNA was determined by differential analysis of breast cancer expression data and survival analysis. Differentially expressed miRNAs and target mRNAs that had binding sites with target lncRNA were predicted. GSEA software was used to carry out pathway enrichment analysis for mRNAs. Binding of the researched genes were tested with RNA binding protein immunoprecipitation (RIP). How miR-301b-3p bound TGFBR2 mRNA was tested by dual-luciferase method. Transwell, colony formation, EdU approaches were employed for verification of invasion and proliferation of breast cancer cells in each treatment group.

Results: Markedly inactivated ADAMTS9-AS1 in breast cancer pertained to patient’s prognosis. MiR-301b-3p was capable of binding TGFBR2/ADAMTS9-AS1. However, overexpression of ADAMTS9-AS1 stimulated miR-301b-3p binding ADAMTS9-AS1 and repressed miR-301b-3p binding TGFBR2 mRNA. ADAMTS9-AS1 interference enhanced cancer proliferation and invasion, facilitated levels of KI67, PCNA, MMP-9 and MMP-2, and activated the JAK STAT signaling pathway. While silencing miR-301b-3p reversed the effect of ADAMTS9-AS1 interference. In addition, TGFBR2 interference or restraining JAK STAT signaling counteracted the effect of ADAMTS9-AS1.

Conclusion: ADAMTS9-AS1 could sequester miR-301b-3p to inhibit progression of breast cancer via TGFBR2/JAK STAT pathway. This study supplies a rationale for incremental apprehension of ADAMTS9-AS1 in breast cancer progression.