bluuebunny/crossref_metadata_2025 huggingface dataset:
URGENSI PENERAPAN ONLINE HYBRID ARBITRATION PADA BADAN ARBITRASE NASIONAL INDONESIA (BANI) SEBAGAI MODEL ALTERNATIF PENYELESAIAN SENGKETA BISNIS INTERNASIONAL DI INDONESIA PADA MASA PANDEMI COVID-19
Authors: Pratama Kristianus Jimy
Published: June 2024

Abstract
The state of the Corona Virus Disease 2019 (Covid-19) pandemic has had a negative impact on the implementation of international business dispute forums in Indonesia. It is undeniable that international business disputes are increasing due to the increasing number of creditors who are unable to fulfill their achievements in the midst of implementing strict health protocols that do not allow optimal face-to-face processes. The increase in the number of creditors also encourages alternative business dispute resolution models to be more efficient in their implementation. This research is normative legal research that uses a statutory and conceptual approach. Based on the results of the study, the litigation route for resolving international business disputes in Indonesia is not sufficient to respond to a special pandemic situation. In addition, the path of dispute resolution outside the court is also not optimal by applying the hybrid arbitration model. This is because there is no legal instrument that specifically regulates this matter. The modification of the hybrid arbitration model into online hybrid arbitration can theoretically encourage the strengthening of efficient international business dispute resolution during the pandemic.
Abstrak
Keadaan pandemi Corona Virus Disease 2019 (Covid-19) memberikan dampak negatif terhadap penyelenggaraan forum sengketa bisnis internasional di Indonesia. Adapun tidak dapat dipungkiri bahwa sengketa bisnis internasional meningkat karena bertambahnya jumlah kreditur yang tidak mampu memenuhi prestasinya di tengah penerapan protokol kesehatan secara ketat yang tidak memungkinkan proses tatap muka secara optimal. Peningkatan jumlah kreditur tersebut juga turut mendorong model alternatif penyelesaian sengketa bisnis untuk lebih efisien dalam penerapannya. Penelitian ini merupakan penelitian hukum normatif yang menggunakan pendekatan peraturan perundang-undangan dan pendekatan konseptual. Berdasarkan hasil penelitian, jalur penyelesaian sengketa bisnis internasional di Indonesia secara litigasi belum memadai untuk merespons keadaan pandemi yang bersifat khusus. Selain itu, jalur penyelesaian sengketa di luar pengadilan juga belum optimal menerapkan model hybrid arbitration. Hal ini disebabkan karena belum terdapat perangkat hukum yang khusus mengatur hal tersebut. Adapun modifikasi model hybrid arbitration menjadi online hybrid arbitration secara teoretis dapat mendorong penguatan penyelesaian sengketa bisnis internasional secara efisien pada masa pandemi.
RECALL ELECTION MELALUI PERADILAN SEBAGAI MEKANISME DEMOKRATISASI PASCA PEMILU
Authors: Bima Rico Pambudi  , Moch. Marsa Taufiqurrohman  , Mohammad Ircham Maulana
Published: June 2024

Abstract
The people’s lack of role and participation in directly monitoring the running of the government after the general election needs to be reviewed. The general election process continues beyond the pre-election and during the election process. The general election process also includes post-election processes. Even though in a democracy, the people occupy the highest position in the constitutional system, their role in government has only been considered limited before and during general elections. This article aims to provide the people with an effective and efficient way to get involved in government as a form of post-election democratic process. This article provides insight for a method of popular participation after the general election. By combining normative juridical research methods and reform- oriented research, this article aims to examine the probability of implementing the Recall Elections method as a form of effort to increase the role of the people after the general election. An example of a form of effort through Recall Elections is direct supervision by the people of their representatives elected in the general election process. Ultimately, this article considers several options for developing normative and political strategies for implementing Recall Elections as a form of post-election widespread democratization in Indonesia.
Abstrak
Minimnya peran dan partisipasi rakyat dalam memantau langsung jalannya pemerintahan pasca pemilihan umum (Pemilu) perlu dikaji ulang. Proses Pemilu tidak hanya terhenti pada proses pra dan pada saat pemilihan. Proses Pemilu juga mencakup proses pasca Pemilu. Meskipun dalam negara demokrasi rakyat menduduki kedudukan tertinggi dalam sistem ketatanegaraan, peran rakyat dalam pemerintahan hanya dianggap terbatas sebelum dan pada saat pemilihan umum. Artikel ini bertujuan untuk memberikan rakyat cara yang efektif dan efisien untuk terlibat dalam pemerintahan sebagai bentuk proses demokrasi pasca Pemilu. Artikel ini mencoba memberikan wawasan tentang kebutuhan sebuah metode partisipasi rakyat pasca pemilihan umum. Dengan menggunakan metode penelitian normatif-doktrinal, artikel ini bertujuan untuk mengkaji kemungkinan penerapan metode Recall Elections sebagai bentuk upaya peningkatan peran masyarakat pasca Pemilu. Salah satu bentuk peningkatan peran masyarakat pasca Pemilu melalui Recall Elections adalah pengawasan langsung oleh rakyat terhadap wakil-wakilnya yang telah dipilih dalam proses Pemilu. Puncaknya, artikel ini mempertimbangkan beberapa opsi untuk mengembangkan strategi normatif dan politik dalam melaksanakan Recall Elections sebagai bentuk demokratisasi yang meluas pasca Pemilu di Indonesia.
La lengua del conquistador
Authors: Zepeda Eraclio
Published: June 2024

Eraclio Zepeda: En los amplios territorios conquistados se hablaban idiomas diversos, agrupados en familias lingüísticas. Los frailes predicadores de la nueva fe, humanistas destacados, sabían la importancia de estas lenguas para diseminar sus principios religiosos. En Tlatelolco y Michoacán instituyeron centros de estudio de los idiomas en que los pueblos se expresaban. Los jóvenes estudiantes mexicanos y los viejos sabios acercaban la grandeza de su lengua en el calmécac. Y, a su vez, aprendían de los frailes el castellano y el latín.
La Escuela Nacional de Música de la UNAM (1929-1940): compartir un proyecto
Authors: Aguirre Lora María Esther
Published: June 2024

El presente trabajo aborda algunas facetas de la fundación y los primeros años de una de las instituciones universitarias abocadas a la formación artística, la Escuela Nacional de Música de la UNAM. El movimiento por la autonomía universitaria (1929) y la lucha de un grupo de estudiantes y profesores del Conservatorio Nacional de Música por conservar su condición de universitarios y resistirse a su reincorporación a la Secretaría de Educación Pública, son historias que se entrecruzan y comparten, en su propia especificidad, la crisis de legitimidad y el esfuerzo por allanar los obstáculos que harían posible la proyección de programas académicos de gran envergadura social.
Emotion Based Music Recommendation System using VGG16-CNN Architecture
Authors: Kiran B. Kranthi
Published: June 2024

Abstract: This research introduces an Emotion-based Music Recommendation System (EMRS) using Convolutional Neural Networks (CNNs) to analyze facial expressions and recommend music tailored to individual emotional states. Unlike traditional systems, EMRS prioritizes facial expression analysis for personalization. CNNs, trained on a diverse dataset of emotional expressions linked to music, extract key emotional features. EMRS leverages this analysis to intuitively suggest music that can potentially aid in emotional regulation. This research not only advances personalized music recommendation but also opens doors for emotion-aware technology with applications in mental healthcare for emotional imbalance and trauma. EMRS has the potential to serve as a complementary tool for therapists and individuals seeking emotional well-being through music
Solar Water Heater Using an IoT
Authors: Wangchuk Tashi Rapden
Published: June 2024

Abstract: Traditional water heaters use a lot of electricity to heat water. Traditional water heaters require a heating coil to heat water, which uses at least 2000 watts. It also requires human intervention. For this reason, we utilize solar energy. Solar energy is not only a clean and renewable alternative to fossil fuels, but it is also environmentally friendly, has a wide range of applications, and has low maintenance costs. Therefore, the aim of this project is to convert solar energy into electrical energy and utilize solar energy to heat water. The solar hot water system includes IoT, solar panels, various modules and various sensors. Based on this measurement, we provide a smart hot water system through a combination of Internet of Things technologies and business processes and decision support systems. Maintaining a traditional water system is inconvenient but often effective when regular human intervention is required. In this project work, the complete workflow of the system is presented.
Contemporary Mathematics Learning: Instagram-based math learning medium increased elementary school students' math literacy
Authors: Darmawati Besse , Darmayanti Rani , Santiago Paulo Vitor da Silva
Published: June 2024

Modern education has shifted from teacher-centred to student-centred. This transition occurs because educators today work as instructional designers, facilitators, trainers, and learning administrators. Globalization and millennial students are destroying traditional schooling. Technology use is rising. This has adverse effects since youngsters are unwilling to utilize books to improve their mathematical literacy. This happens when pupils need help conceiving, applying, and comprehending mathematical concepts. To improve students' mathematical literacy, a teacher must create modern materials. This study is about R&D. This research produced a math learning tool for 12th-graders. The software emphasizes three-dimensional materials and is based on GeoGebra and Instagram. This study uses the Four-D development model: definition, design, development, and deployment. Modern three-dimensional educational materials made with Canva are the results of this research study. These contents will then be posted on Instagram. This essay will comprehensively analyze data collection, analysis, and Instagram content publishing. Currently, this research is in development, not distribution. Test sheets and questionnaires are used. Observation, interviews, questionnaires, and testing collect data. After observation and interviews, a questionnaire is distributed to finish the study. Pre- and post-tests assessed how GeoGebra Instagram content affected students' understanding of "point-to-point distance" in three-dimensional material. The article will detail this media's methods and results.
THE IMPACT OF ISLAMIC BUSINESS ETHICS, ONLINE CUSTOMER REVIEWS, AND ONLINE CUSTOMER RATINGS ON DECISIONS TO PURCHASE HALAL COSMETIC PRODUCTS THROUGH SHOPEE
Authors: Inayah Inayah , Adiba Elfira Maya , Jessy Rachela
Published: June 2024

Purchasing transactions have grown rapidly due to the presence of the Internet. The use of Internet facilities allows business activities to be carried out anywhere and at any time without having to meet the parties in the transaction physically. Business activity using the Internet is called electronic commerce (e-commerce). Currently, in Indonesia, the online shop or online marketplace trend is on the rise. According to Research and Markets, a market research platform, the market in Indonesia is potentially growing by 19.0% throughout 2022. Some of the most popular online shops are Shopee, Tokopedia, Lazada, Zalora, and so on. The study aims to find out the influence of Islamic business ethics, online customer reviews, and online customer ratings on the decision to buy halal cosmetics products through Shopee among students of Trunojoyo Madura University. The study used quantitative methods and purposive sampling with respondents of as many as 100 students. The results of the study showed that Islamic business ethics (X1), online customer review (X2), and online customer rating (X3) have a significant influence on the purchase decision of halal cosmetic products. The combination of all variables studied influences each other in determining the decision of students to purchase illegal cosmetic products.
FACEBOOK MARKETPLACE AS AN ALTERNATIVE TO ADVANCE THE ECONOMY OF THE UMAM: PERSPECTIVE OF ISLAMIC ECONOMIC LAW
Authors: Indra Indra , Iska Syukri , Dayat Dayat , Arianti Farida
Published: June 2024

Penelitian ini bertujuan melihat bagaimana pengaruh transaksi jual beli yang dilakukan melakui platform marketplace facebook apakah dapat memberikan pengaruh terhadap kemajuan ekonomi umat, karena dewasa ini penggunaan teknologi informasi serta internet sangat berpengaruh dalam berbagai lini kehidupan. Penelitian menggunakan metode kualitatif dengan menggunakan Google Scoolar dan Sinta untuk mencari junal serta website yang memberikan informasi yang berkaitan dengan masalah yang dibahas. Hasil analisa ini menunjukkan bahwa bentuk transaksi dengan menggunakan marketplace facebook ini dapat memberikan kemudahan dan efesien karena penjualan secara digital tidak terbatas oleh jarak dan waktu serta bisa mencapai secara global. Dilihat dari total pengguna facebook di Indonesia menjadi peluang yang sangat besar dan strategis bagi umat dalam memajukan ekonomi, dengan cara memanfaatkan marketplace facebook sebagai tempat untuk memasarkan produk dan bertransaksi jual beli dan selama transaksi jual beli yang dilakukan sesuai dengan syarat dan rukunnya serta dilakukan secara online menggunakan matketplace facebook maka transaksi jual beli itu akan sah dan sesuai dengan ketentuan hukum Islam.
Supervisory bodies in the systems of power in Russia and certain foreign countries: Comparative analysis
Authors: Rokityanskii Sergei G.
Published: June 2024

The significance of law enforcement cannot be understated in any state, and diverse models and traditions of law enforcement have evolved within different legal sustems. The status of the Procuracy in the Russian Empire, the Soviet Union and modern Russia, has been consistently characterized by its own independent power for supervising legality, including the actions of government officials. This contrasts with the European and Anglo-American legal systems where the concept of “general supervision” is not present and prosecutors do not possess equivalent powers. In the socialist model of China, an independent system of supervisory bodies has been established separately from the procurator’s office to oversee the activities of government officials. Each model exhibits distinct ontological, structural and organizational features, and a comparative analysis of their accumulated experiences facilitates the identification of their respective advantages and disadvantages, underscoring the relevance of this study. The research aimes to identify and analyze the commonalities and differences among four organizational models for ensuring the rule of law. Notably, the empirical basis for comparing supervisory authorities emphasises the state superiority function, irrespective of the body responsible for its execution (functional approach), rather than external similarities such as the name "prosecutor's office" or "prosecutor". The study draws from authentic legal texts, regulations, authoritative doctrinal commentaries, relevant judicial practices, and official interpretations of foreign legislation. The outcomes of the research lead to informed conclusions regarding the distinctiveness of the Russian model of the Procuracy, which incorporates several advantages from each foreign model, complements them with its own features and is thus capable of embracing positive experiences, regardless of their origins, to effectively filfill its mission.
Incorporation of foreign timber concessions in Soviet Russia in the 1920s
Authors: Minchuk Oleg. V. , Zaozerskiy Daniil S. , Nikiforov Aleksey S.
Published: June 2024

The article based on legislative acts of Soviet Russia and unpublished sources of the State Archive of the Arkhangelsk Oblast, describes the features of incorporation of Russangloles, Russhollandoles and Russnorvegoles joint-stock companies, operating in the North of Russia in the 1920s. The article analyzes the Standard Agreement on Timber Concessions (1922), which was used by the Soviet state and foreign entrepreneurs in the process of drafting concession agreements in the timber industry and the Scheme for Constructing a Standard Agreement on Timber Concession. The study of these sources allows reconstructing the principle of forming contracts contributing to Russangloles, Russhollandoles and Russnorvegoles functioning.
Constitutional legal understanding: historical, theoretical and sectoral aspects
Authors: Romashova Maria R. , Panchenko Vladislav Yu.
Published: June 2024

In the context of the constitutional law of Russia, the problem of interpreting the Constitution has traditionally been reduced to different views on it as a written document with a special political and legal status. In different periods of Russian history, the Constitution was perceived differently, which was reflected in different understandings of the relationship between the Constitution and the state, the Constitution and legislation, the constitution and human rights. One of the important aspects for the interpretation of the constitution was the interaction between the Constitution and constitutionalism, as well as state and constitutional law. Within the framework of this problem, the object is the phenomenon of constitutional legal understanding, considered as a theoretical and praxiological construction that combines scientific views and empirical ideas reflecting the formal and substantive features of the Constitution and constitutional law at different stages of the development of the legal system of Russia. The article explores the problem of legal understanding and law understanding in the domestic legal tradition, the understanding of the Constitution in the context of cyclical politogenesis, as well as the problem of constitutional law understanding in the context of the concept of a «living» Constitution.
Proof and proving: legislative technique of criminal procedure laws of the Republic of Moldova and the Russian Federation
Authors: Vereshchagina Alla V.
Published: June 2024

Proof and proving lies at the heart of criminal procedure regulation, significantly impacting the quality of law enforcement. In the post-Soviet states that once shared a unified legal system during the USSR dissolution, original criminal procedural laws emerged, exhibiting intriguting examples of evidence and proof rules’ layout. The purpose of the study is to discern the distinct design characteristics of evidence and prove institutions in the criminal procedure laws of the Republic of Moldova and the Russian Federation. The study’s methodological framework rests upon the general scientific principles of cognition such as objectivity, comprehensiveness, pluralism, and historicism. It employs historical, formal-logical and comparative methods, as well as document analysis. By comparing the normative models of evidence and proof institutions in Moldovan and Russian criminal procedure laws, a shared approach to the concept of evidence as a fusion of form and content becomes apparent. Distinct features of the Moldovan criminal procedure law include the systemic and structured arrangement of evidence rules, the formal adoption of the concept of a means of proof, and precise use of terminology. Conversely, the Russian criminal procedure law disperses evidence rules actoss general and specialized sections, leading to regulatory duplications and terminologicals inaccuracies. The historical roots of the evidence and proof institution layout trace back to November 20, 1864, Charter of Criminal Procedure. The Charter’s systematization of norms reflected the nuances of the pre-revolutionary Russian process. Despite the subsequent stage structuring evolution during the Soviet era and procedural form differentiation, the Soviet legislator retained the pre-revolutionary rules’ systematization on evidence. Presently, the current criminal procedure law maintains much of the previous regulatory content, highlighting essential areas for enhancement in evidence and proof institution design to allign more closely with the process’ stage structure and procedural form differentiation, thus mitigating potential abuse of rights. Addressing these design shortcomings is crucial. Rectifing Russian legistation following the comparative study allows drawing insights from Moldova’s legislative experience.
Review of the IV scientific and practical seminar held at the First Court of Appeal of General Jurisdiction on December 1, 2023, on Copyright Protection and (or) Related Rights in Information and Telecommunications Networks, Including the Internet
Authors: Lepeshin Dmitry A. , Dautiya Tatyana V.
Published: June 2024

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Book announcement: Krylov, V.G., Samoilov, I.A., Sedgaryan, K.A (2004) Business Entity as a Form of Running Business: Textbook. Moscow, Statut Publishing House
Authors: Leskova Julia G.
Published: June 2024

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Polymodality of perception and its reflection in fiction text: Сognitive and semiotic perspectives
Authors: Kozlova Lyubov A. , Kremneva Anna V.
Published: June 2024

The issues related to the polymodality of perception and various forms of intermediality are widely discussed in linguistics whereas the aspect of their interrelation is seldom considered. This research is aimed at tracing the participation of various modes of perception in the process of interaction with the world, the reflection of this process in our consciousness and memory in the form of various images up to the manifestation of those images in the intermedial relations in fiction text. The study draws on cognitive semiotics, text linguistics, polymodality and intermediality. The theoretical analysis sugessts that the polymodality of perception results in the formation of synesthetic mental images represented in the phenomenon of intermediality. The empirical material of the research includes text fragments from the works by Virginia Woolf, James Joyce, Joyce Cary and Adam Thorpe containing samples of linguа-artistic and linguа-musical techniques of writing as forms of intermediality. The intermedial analysis of the empirical material shows how the polymodality of perception determines the specificity of the authors’ creative thinking represented in the choice of language means that activate musical and visual images in the readers’ minds. As a result, such fiction texts are constituted as related to a specific art whose forms and devices are used in it. The analysis has also revealed that in the process of verbal representation of musical or artistic images language exploits all forms of its semiotic signs: symbols (for naming colours, shades of light, sounds of music), indices (allusions to works of art or their authors) and icons (the use of forms and devices characteristic of other arts). The study confirms the productivity of exploring intermedial interaction in the cognitive and semiotic perspectives to demonstrate the relations between perception, conceptualization and the embodiment of the results in fiction text.
Análise compreensiva das contribuições do design estratégico para o modelo de gestão em uma empresa da economia criativa
Authors: Schreiber Dusan , Koch Berlitz Débora , Reche Franciele , Viana Luciane Pereira Viana , Schmidt Serje schmidt
Published: June 2024

Este artigo teve como objetivo evidenciar as contribuições dodesignestratégico para o modelo degestão em uma empresa da economia criativa. O pressuposto teórico estruturante e subjacente aodesenvolvimento do estudo apoia-se na compreensão da relevância da gestão estratégica para a con-cepção do modelo de negócios, considerando que as empresas que operam em atividades classifica-das como da economia criativa evidenciam especificidades que demandam ajustes no seu processo degestão, que pode encontrar respaldo em vertentes teóricas relacionadas aodesignestratégico. Paraa realização do estudo, optou-se pela estratégia de estudo de caso único e abordagem qualitativa,por entender que, desta forma, seria facultado evidenciar aspectos subjetivos e sutis que permeiam otecido organizacional e influenciam tanto o corpo diretivo como a equipe de colaboradores. A coletade dados empíricos ocorreu na segunda quinzena do mês de setembro do ano de 2022, por meio deentrevista em profundidade com a gestora da organização, bem como levantamento documental.Os resultados evidenciaram as características da organização, que opera em uma das atividades daeconomia criativa, bem como os desafios que demandam adaptação do modelo de gestão, que é in-fluenciado pelodesignestratégico, facultando, desta forma, o alcance dos objetivos organizacionais.
Economia criativa: um olhar cronológico
Authors: Watanabe Jefferson Yuji , De Moraes Barbosa Borges Larissa , Guilherme Luciana
Published: June 2024

Fruto de uma nova compreensão das relações entre os campos da cultura e da economia no iníciodo século XXI, as atividades da economia criativa têm sido destacadas como alternativas para ocrescimento e o desenvolvimento econômico de países em todo o mundo. Simultaneamente, umasérie de estudos acadêmicos tem se dedicado ao assunto, ampliando perspectivas e reflexõessobre o campo. Devido à crescente projeção internacional do tema, em grande parte devido àatuação de organismos internacionais como a Conferência das Nações Unidas sobre Comércio eDesenvolvimento (UNCTAD) e a Organização das Nações Unidas para a Educação, a Ciência e aCultura (UNESCO), torna-se relevante a apresentação e a sistematização de uma visão abrangentesobre a área, com o objetivo de introduzi-la a um público mais amplo e envolvido neste mercado,incluindo representantes do poder público e da sociedade civil. Por esse motivo, este artigo apre-senta uma revisão da literatura sobre o campo da economia criativa, seguindo uma abordagemcronológica, e uma linha do tempo dos principais acontecimentos e estudos da área, tanto emnível internacional quanto brasileiro.
Campus escola e juventude
Authors: Leivas Marcela
Published: June 2024

A partir da recuperação da concepção de Campo Escolar proposta pelo enfoque Genético-Estrutural, cujo maior expoente é Pierre Bourdieu, este artigo explora as estratégias estudantis de jovens que frequentam escolas secundárias na cidade de Tandil, província de Buenos Aires, Argentina, de forma a permanecer com sucesso no espaço escolar. Especificamente, a partir da aplicação de um inquérito qualitativo a grupos de jovens que frequentam o terceiro e sexto ano de três escolas secundárias diferenciadas (uma privada urbana, uma pública urbana e uma estatal suburbana) são analisados ​​os seus percursos institucionais anteriores, as suas concepções de educação, as suas práticas, as suas aprendizagens, as suas questões, as suas relações com os outros jovens e com os adultos e as suas expectativas para o futuro. Esta análise é realizada de duas formas, uma que compara as respostas de cada grupo de jovens, e outra que analisa especificamente as respostas de cada grupo. Para, finalmente, estabelecer um conjunto de constatações que nos permitem dar conta da rede de relações que está na base da ligação que cada grupo de alunos estabelece com as suas escolas de referência, e que dá conta das distâncias e/ou aproximações que os caracterizam entre si, outro estabelecendo algumas configurações típicas do Campo Escolar da cidade.
Mitigating the COVID-19 Induced Learning Loss in Rural Primary Schools: How Do Teachers Prepare English FAL Learners for Self-Directed Learning in the ‘New Normal’?
Authors: Mokoena Mosebetsi
Published: June 2024

In the post-pandemic era, the ongoing discourses are centered around finding innovative ways to sustain teaching and learning as well as reversing COVID-19-induced learning loss, especially in critical areas, such as reading in English First Additional Language (FAL). As a contribution to these discourses, the current study explored how teachers prepared rural English FAL learners for self-directed learning to mitigate COVID-19-induced learning loss and to sustain learning in the ‘new normal’. The study followed a qualitative approach and adopted phenomenology as a research design, while the Capability Approach was used for theoretical framing. Three teachers of English FAL in one primary school were conveniently selected to participate in the semi-structured focus-group interviews. A thematic analysis revealed that teachers prepared English FAL learners to use self-directed learning by apprising learners of their active role in learning English FAL, identifying learners’ weaknesses, strengthening the home-school connection, and encouraging collaboration and problem-solving. These findings imply that self-directed learning could be a useful strategy for mitigating COVID-19-induced learning loss and improving reading skills in rural primary schools.
Development of a population pharmacokinetic model for the novel long-acting injectable antipsychotic Risperidone ISM®
Authors: Laveille Christian , Snoeck Eric , Monasterioguren Lourdes Ochoa Díaz de , Martínez-González Javier , Llaudó Jordi , Anta Lourdes , Gutierro Ibon
Published: June 2024

To develop a population pharmacokinetic (PK) model for risperidone ISM®
and to investigate relationships between active moiety exposure, as
described by apparent clearance (CL40), and several covariates using all
data from five clinical studies. A population PK model was developed
using active moiety concentrations from a study in healthy volunteers
and two studies in patients with schizophrenia. Data from a comparative
bioavailability study in medically stable patients and a Phase III study
in patients with acute exacerbation of schizophrenia were then
incorporated, using empirical Bayesian feedback and model refinement in
NONMEM. Finally, covariate analysis was performed on CL40. The final
model adequately described the pharmacokinetics of 6288 active moiety
concentrations in 17 healthy volunteers and 430 patients with
schizophrenia. This one-compartment disposition model had a complex
absorption process, combining a small amount immediately entering the
central active moiety compartment, two first-order absorption processes
and a combined zero-order and first order process, with first-order
elimination from the central compartment. Significant covariates on CL40
were BMI and sex. Goodness of fit (GOF) plots and visual-predictive
checks (VPC) confirmed acceptable description of the data. The
population PK model adequately described active moiety concentrations
from five clinical studies after risperidone ISM® administration.
Relationships between active moiety exposure and covariates were defined
to facilitate simulations for future studies. The model showed that
risperidone ISM® rapidly achieves therapeutic plasma levels within first
hours after the first injection that are maintained sustainedly
throughout the whole dosing interval following once-monthly gluteal
injections for 100 mg and 75 mg.
Glycopeptide antibiotics and DRESS syndrome: a real world study leveraging the FDA Adverse Event Reporting System (FEARS)database
Authors: Li Chen-sui-zi , Han Mei-fen , Gao Qian , Dong Hong-liang , Li and Zhi-ling
Published: June 2024

Background This study assessed the risk of Drug reaction with
eosinophilia and systemic symptoms (DRESS) associated with various
glycopeptide antibiotic treatments, including vancomycin and linezolid.
Methods Disproportionality and Bayesian analyses were conducted on data
spanning from the first quarter of 2006 to the first quarter of 2023,
extracted from the Food and Drug Administration Adverse Event Reporting
System, to delineate the signal discrepancies associated with
glycopeptide antibiotic-induced DRESS. Results In the studied cohort, a
total of 11,155,106 cases were identified, with the majority of affected
individuals falling within the 18 to 44 age range. DRESS syndrome was
most frequently reported in association with vancomycin and linezolid
treatments. Disproportionality and Bayesian analyses revealed a strong
association between vancomycin and the occurrence of DRESS. An
intraclass correlation analysis comparing vancomycin and linezolid in
relation to DRESS syndrome yielded a ranking with vancomycin
demonstrating a higher Reporting Odds Ratio (ROR=54.21; 95% Confidence
Interval [CI]: 50.00–58.78) than linezolid (ROR=4.04; 95% CI:
2.97–5.49). Additionally, the outcomes of DRESS syndrome induced by
vancomycin and linezolid were observed to differ. Conclusions Utilizing
data from the Food and Drug Administration Adverse Event Reporting
System database, it was determined that vancomycin exhibits a
significant association with Drug Reaction with Eosinophilia and
Systemic Symptoms (DRESS) syndrome. Furthermore, among the glycopeptide
antibiotics, vancomycin and linezolid were identified as having the
highest risk of inducing DRESS syndrome. However, due to potential
indication bias, additional clinical research is imperative to ascertain
the safety profile of glycopeptide antibiotics conclusively.
Bibliometric Examination of "Bona Vacantia": Charting Patterns and Research Trends
Authors: Abdullah Sanek Siti Khadijah , Halim Akmal Hidayah
Published: June 2024

This paper employs a bibliometric analysis to examine the primary sources of publication, authorship, citations, and research trends concerning Bona vacantia. Bona vacantia, often known as ownerless property, carries significant legal and economic significance on a global scale. Comprehending the academic discussion surrounding a topic benefits legal professionals, policymakers, and researchers. Retrieving 645 relevant articles from the Scopus database spanning 2003 to 2023, the study employs data refining and various bibliometric methods, including cluster and network analysis and word cloud generation. The analysis reveals 158 contributors from 69 countries, predominantly publishing articles. It identifies key articles, authors, and journals shaping the discourse on Bona vacantia. Although the insights provided are valuable, it is crucial to understand the limits in terms of database coverage, chronology, and paper scope. Future research should incorporate diverse databases and extend temporal perspectives to understand Bona vacantia comprehensively. This study recommends a broader research expansion to enhance understanding of this multifaceted subject.
Plasma Biomarkers of Brain Injury and Their Association With Brain MRI and Cognition in Type 1 Diabetes
Authors: Karger Amy B. , Nasrallah Ilya M. , Braffett Barbara H. , Luchsinger José A. , Ryan Christopher M. , Bebu Ionut , Arends Valerie , Habes Mohamad , Gubitosi-Klug Rose A. , Chaytor Naomi , Biessels Geert J. , Jacobson Alan M. ,   DCCT/EDIC Research Group
Published: June 2024

OBJECTIVE

To evaluate associations between plasma biomarkers of brain injury and MRI and cognitive measures in participants with type 1 diabetes (T1D) from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study.

RESEARCH DESIGN AND METHODS

Plasma amyloid-β-40, amyloid-β-42, neurofilament light chain (NfL), phosphorylated Tau-181 (pTau-181), and glial fibrillary acidic protein (GFAP) were measured in 373 adults who participated in the DCCT/EDIC study. MRI assessments included total brain and white matter hyperintensity volumes, white matter mean fractional anisotropy, and indices of Alzheimer disease (AD)–like atrophy and predicted brain age. Cognitive measures included memory and psychomotor and mental efficiency tests and assessments of cognitive impairment.

RESULTS

Participants were 60 (range 44–74) years old with 38 (30–51) years’ T1D duration. Higher NfL was associated with an increase in predicted brain age (0.51 years per 20% increase in NfL; P < 0.001) and a 19.5% increase in the odds of impaired cognition (P < 0.01). Higher NfL and pTau-181 were associated with lower psychomotor and mental efficiency (P < 0.001) but not poorer memory. Amyloid-β measures were not associated with study measures. A 1% increase in mean HbA1c was associated with a 14.6% higher NfL and 12.8% higher pTau-181 (P < 0.0001).

CONCLUSIONS

In this aging T1D cohort, biomarkers of brain injury did not demonstrate an AD-like profile. NfL emerged as a biomarker of interest in T1D because of its association with higher HbA1c, accelerated brain aging on MRI, and cognitive dysfunction. Our study suggests that early neurodegeneration in adults with T1D is likely due to non-AD/nonamyloid mechanisms.
Building academic capacity in physical and rehabilitation medicine
Authors: Sjölund Bengt
Published: June 2024

None
Repositioning Power Relations in Indigenous Social Work Education
Authors: Jensen Bonnie , Arnfjord Steven
Published: June 2024

In this article, we present the history of social work education in Greenland, from a professional training school in 1985 to a university BA-level education in 2008 and onwards to the present day. Mainly, we discuss how the education of Greenlandic social workers continually reflects on the decolonising elements of the curriculum.
The latest step in this process has been the development of a new curriculum, which came into effect in the summer of 2022 after approval from students, external boards and the academic university board. The article will discuss the repositioning of power in the new social work curriculum, aiming to gradually make education more student-centred through a higher degree of collective responsibility for learning and by engaging in problem-oriented group work with self-determined research questions at the core of Greenlandic, thematic, social worker projects.
Sero-Conversion Status of Different Breeds of Chickens Vaccinated With Newcastle Disease I2 Vaccine Type around Hawassa, Ethiopia
Authors: Z* emeke
Published: June 2024

Chickens are vaccinated with live attenuated and inactivated vaccines in order to control Newcastle disease (ND). The vaccine can be administered by eye drop, aerosol or drinking water. Humoral antibodies usually appear within 6 to 10 days after vaccination in the serum and also locally in the upper respiratory tract and in the intestine. The efficacy of vaccinations can be estimated best with challenge experiments but they are expensive and time consuming. For the current study, a cross sectional study was conducted to determine the sero-conversion status of ND I-2 vaccine type provided to chicken reared in intensive, semi-intensive and extensive farms in Sidama region, Ethiopia. Of the total 401 samples collected from 29 various flock sizes 363(90.5%) were protective at individual bird level; whereas at flock level 86.2% (25/29) were met above 80% protection. Of 29 flocks 12 (42.4%) flocks were found 100% protective from the disease. The CV% varied between 21.2% and 122.3 percent among the flocks. The uniformity of average antibody titer for Bovans breed (CV%: 56.7) was comparatively better followed by Sasso (CV%: 69.2), Local breed (CV%: 73.1) and mixed breeds (CV%: 83). The overall average minimum, maximum and mean antibody titer for this study was 1179.8, 13840.1 and 5945, respectively. However, the minimum and maximum antibody titer for this study was 37.4 for Sasso breed with the age of 8 months and 20465.8 for mixed type of breed with the age of 12 months respectively. Significant antibody titer variation was observed among Breeds (p=0.018) and Ages (p=0.001) of the birds in this study. In general, the vaccination scheme for the current study revealed ND I-2 vaccine type was effective in protecting the chickens from the disease in respective of the age of birds at vaccination although the pattern of uniformity for antibody production is variably interrupted among the flocks.
Who donates food purchase data for research? Results from two nationwide data collection efforts in Finland
Authors: Vuorinen Anna-Leena , Vepsäläinen Henna , Meinilä Jelena , Lehto Elviira , Saarijärvi Hannu , Erkkola Maijaliisa , Fogelholm Mikael , Nevalainen Jaakko
Published: June 2024

Introduction & BackgroundFood retailers’ transaction data are increasingly used for research. Unlike many other digital footprints, the representativeness of automatically accumulating food purchase data as such is less biased as food is consumed by all individuals. However, the process of obtaining individual/household level data requires consents from the consumers and, thus, may create selection bias.
Objectives & ApproachThe aim of this work is to describe the recruitment process and participant characteristics in the Finnish LoCard study to evaluate the selection mechanism.
The Finnish LoCard study comprises two cohorts collected in 2018 and 2023 with 47,066 and 42,340 participants, respectively, who have consented to release their food purchase data for research. The study collaborates with S group, the leading retailer in Finland with 47% market share. Members from their loyalty card program were invited to consent to their purchase data being used for research and voluntarily respond to a background questionnaire.
Relevance to Digital FootprintsOur analyses may provide further insights into the selectivity of consumers who are willing to share their purchase data for research purposes.
ResultsFor both LoCard cohorts, all loyalty card holders (n~2.3M) were considered. In LoCard I, the invitations were sent to 1.1M primary card holders with confirmed email addresses, of whom 47,066 (3.9%) participated and consented to their purchase data being used for research. In this cohort, women, middle-aged individuals, individuals with higher education, and employed individuals were overrepresented whereas the retired individuals, those with lower education and individuals with children were underrepresented. In the LoCard II, loyalty card holders (n ~2.24M) with an email address were invited. Of these, 852,009 (37.7%) opened the invitation link, and a further 42,340 provided the consent, resulting in response rate of 1.9% from the original population and 4.9% from those reacting to the email invitation. Data on the characteristics of LoCard II participants are not available yet but will be presented in the conference presentation.
Conclusions & ImplicationsThis work investigates selection mechanisms in the Finnish LoCard study and evaluates the feasibility of reaching underrepresented groups in health studies, such as socioeconomically disadvantaged groups or young men, through a combination of loyalty card program and email invitations.
Development and use of a co-produced short mood survey to collect ground truth in digital footprints research
Authors: Di Cara Nina , Davis Oliver , Haworth Claire
Published: June 2024

Introduction & BackgroundTo use digital footprint data for mental health and well-being research we often need to collect concurrent, high-quality measures of ground truth. Delivering frequent surveys to participants using an ecological momentary assessment (EMA) methodology is one way to collect such data. However, existing surveys tend to be long, not focused on momentary states or rely on rating images which are not platform agnostic. Here we present a five-item test-based survey designed with participants and validated for use in EMA studies to collect data about momentary changes in mood. We describe its methodological development and how it has been used to investigate music listening on Spotify as a digital footprint of mood.
Objectives & ApproachThe survey is based on the circumplex model of affect. It was co-produced with a participant advisory group (N=5), who gave feedback on the length, content and delivery of the survey. It was then piloted in a group of N=98 participants to assess statistical validity, and congruence with the 20-item Positive and Negative Affect Schedule (PANAS). Following this it was delivered in a wider sample (N=150) four times a day over a two-week period using an EMA app on participant’s phones.
Relevance to Digital FootprintsEMA is an increasingly popular method for collecting ground truth to support the interpretation of digital footprint data. This newly developed and tested mood survey offers an opportunity to reduce participant burden for collecting mood data in EMA studies which will support the collection of high quality and high time-resolution ground truth for digital footprints research.
ResultsTogether with participants we selected four emotions across the axes of arousal and valence, as well as rumination which participants considered important in their music listening behaviors. Factor analysis of pilot data showed that the questions represented two factors of positive and negative affect. The ratings on a 0-10 scale of the emotions ‘cheerful’ and ‘relaxed’ explained 44% of the variance in positive affect, and ratings of ‘worried’, ‘sad’ and ‘frustrated’ explained 40% of the variance in negative affect. Delivery of the questionnaire in a wider student sample (N=150) four times per day for two weeks allowed for the opportunity to assess typical response rates in a realistic EMA setting. On average participants completed 3 out of the 4 surveys a day.
Conclusions & ImplicationsThe co-created, short mood survey for the collection of ground truth in digital footprint studies was validated across two independent samples, and shown to allow for good response rates in a two week study. Future testing on wider samples will provide opportunities to validate the survey and assess its effectiveness across demographic groups and different sample types.
Enhancing ESP Learning: Investigating Students' Perspectives on Real-Time Written Corrective Feedback Delivery via Google Docs
Authors: Susilawati Susilawati , Halim Nurhasanah , Dwigustini Retno , Alakhali Samah Rashad Abdallah
Published: June 2024

The present research aims to investigate the practice of real-time or synchronous written corrective feedback (SWCF) delivery via Google Docs as a platform to deliver feedback, known as a linguistic feedback tool (LiFT) in ESP (English for Specific Purposes) classes, students’ preferences and viewpoints of SWCF. The research employed a qualitative case study involving 15 students from an advanced English correspondence course in a non-English department of a private university in Depok, West Java, Indonesia. Open-ended questionnaires, document analysis, and semi-structured interviews were used to gather the data. The findings revealed that auto-generated and human feedback are used to deliver SWCF via Google Docs, inferring that those features can build students' awareness of language aspects, content, and context in composing professional documents. Direct feedback was delivered more frequently, regarding the learning time efficiency and the students’ ability to identify errors. Further, the students preferred frequent SWCF, direct and indirect feedback, and correcting delivery methods. Finally, they considered that SWCF delivered via Google Docs assists them in improving letter accuracy. Their preferences and viewpoints might allow the lecturer to choose appropriate feedback delivery strategies and material reinforcement. The present research implies a balanced use of auto-generated and human feedback from LiFT in SWCF delivery. Evaluating the effectiveness of SWCF delivery via Google Docs for different levels of achievers in ESP classes might be a potential area of future research. Other LiFTs’ infusion into ESP classes is also worth researching to provide language instructors with alternative applications for SWCF delivery.
Modelo praxeológico alternativo para a identificação de números primos
Authors: Souza Gladys Maria Bezerra de , Silva João de Ribamar , Nunes José Messildo Viana
Published: June 2024

Este artigo tem por objetivo apresentar um modelo praxeológico alternativo para identificação dos números primos em um intervalo qualquer de números. O estudo fundamenta-se na Teoria Antropológica do Didático (TAD). O modelo alternativo refere-se à criação de duas fórmulas que, combinadas, são geradoras de números primos em qualquer intervalo de número. Tais fórmulas foram construídas a partir de modelos de referência da álgebra básica e de conceitos da teoria dos números. Prospecta-se que o modelo construído seja aplicado nas escolas de educação básica e nos cursos de licenciatura que lidam com matemática, em variados níveis.