bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of immediate extubation in the operating room on long-term outcomes in living donor liver transplantation: a retrospective cohort study
Authors: Yoon Jung-Pil , Yoon Ji-Uk , Kim Hye-Jin , Park Seyeon , Yoo Yeong Min , Shon Hong-Sik , Lee Da Eun , Kim Eun-Jung , Kim Hee Young
Published: January 2025

Background: Living-donor liver transplantation (LDLT) is a viable alternative to deceased-donor liver transplantation. Enhanced recovery after surgery protocols that include early extubation offer short-term benefits; however, the effect of immediate extubation in the operating room (OR) on long-term outcomes in patients undergoing LDLT remains unknown. We hypothesized that immediate OR extubation is associated with improved long-term outcomes in patients undergoing LDLT.Methods: This retrospective cohort study included 205 patients who underwent LDLT. The patients were classified based on the extubation location as OREX (those extubated in the OR) or NOREX (those extubated in the intensive care unit [ICU]). The primary outcome was overall survival (OS), while secondary outcomes included ICU stay, hospital stay duration, and various postoperative outcomes.Results: Among the 205 patients, 98 (47.8%) underwent extubation in the OR after LDLT. Univariate analysis revealed that OR extubation did not significantly affect OS (hazard ratio [HR]: 0.50, 95% confidence interval [CI]: 0.24–1.05; P = 0.066). Furthermore, multivariate analysis revealed no statistically significant association between OR extubation and OS (HR: 0.79, 95% CI: 0.35–1.80; P = 0.580). However, OR extubation was significantly associated with a lower incidence of 30-day composite complications and shorter ICU and hospital stays. Multivariate analysis indicated that higher preoperative platelet counts, increased serum creatinine levels, and a longer surgery duration were associated with poorer OS.Conclusions: Immediate OR extubation following LDLT surgery was associated with fewer 30-day composite complications and shorter ICU and hospital stays; however, it did not significantly improve OS compared with ICU extubation.
Noticeable changes in diaphoresis severity following pain management medication adjustments in a complex regional pain syndrome patient
Authors: Lee Joon Hee , Choi Eun Joo , Lee Pyung-Bok
Published: January 2025

Background: Serotonin syndrome results from the use of serotonergic agents that elevate intrasynaptic serotonin level or excessively activate serotonin postsynaptic receptors. Common serotonergic agents used for pain management include opioids, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants.Case: A 24-year old woman diagnosed with complex regional pain syndrome underwent multidrug therapy for pain management over approximately five years. During this period, changes in diaphoresis severity were noted following adjustments to pain medications. The concurrent use of multiple serotonergic agents, exacerbation of diaphoresis after the addition or dose escalation of opioids, and resolution of symptoms upon discontinuation of duloxetine (Cymbalta®, Lily S.A.) strongly suggest the development of serotonin syndrome.Conclusions: Diagnosing serotonin syndrome without neuromuscular symptoms can be challenging. Careful monitoring of changes in symptoms and signs following medication use is essential in such cases.
Soil bacteria v1
Authors: Bergqvist John
Published: January 2025

The behaviour of C. elegans is dependent on its microbial environment. This protocol describes how to utilise the Tierpsy Tracking software to extract the unique behaviours of C. elegans upon being subjected to 96 different soil bacteria. We expect varied behaviours driven by the soil bacteria identity.
Mutagenicidad y genotoxicidad en fracciones de PM2,5 del aire de Villa del Rosario, Colombia
Authors: Meléndez-G. Iván , Quintero-S. Greila P. , Quijano-Parra Alfonso
Published: January 2025

Las partículas atmosféricas constituyen uno de los contaminantes atmosféricos más importantes, debido a que contienen metales e hidrocarburos aromáticos policíclicos (HAP) que son compuestos con conocida actvida genotóxica, mutagénica y carcinogénica. Las particulas finas con diámetro menor a 2,5 μm (PM2,5) producidas por la combustión de los vehículos diésel están implicadas en efectos sobre la salud humana. El propósito de esta investigación fue determinar la actividad mutagénica y genotóxica de la fracción respirable del PM2,5, presente cerca de la avenida fronteriza de alto flujo vehicular en Villa de Rosario (Norte de Santander), la cual comunica los países de Colombia y Venezuela. El PM2,5 fue evaluado con filtros de cuarzo Pallflex. La actividad mutagénica y genotóxica de los extractos del PM2,5 fue determinada mediante la prueba Ames y el ensayo cometa. En la prueba de Ames se utilizaron las cepas TA98 y TA100 de Salmonella typhimurium y el daño genotóxico se evaluó en linfocitos de sangre periférica. Los resultados mostraron mutagenicidad y genotoxicidad asociada con la fracción PM2,5 en Villa del Rosario, lo cual representa un riesgo en la aparición de enfermedades como el cáncer en la población expuesta.
Actividad antiplasmodial y antibacterial in vitro de extractos de la corteza de Erythrina fusca Lour. (Fabaceae)
Authors: Jiménez-Acosta Donys , Márquez-Vizcaíno Rita , De la Rosa-Torres Catalino , Pabón-Vidal Adriana
Published: January 2025

El tamizaje fitoquímico del extracto en etanol de la corteza seca de Erythrina fusca Lour (Fabaceae), determinó la presencia de alcaloides, flavonoides, terpenos y quinonas. Las fracciones en cloroformo y acetona del extracto en etanol de la corteza seca de E. fusca, presentaron actividad antiplasmodial in vitro en las cepas NF54 y FCB-2 de Plasmodium falciparum, con concentración inhibitoria (IC50) de 12,95, 18,02, 16,60 y 28,36 μg/ml y porcentajes de inhibición promedio máximo de 70,72, 69,74, 87,07 y 85,73%, respectivamente. El extracto en etanol mostró efecto antibacteriano in vitro a la concentración de 20 mg/ml sobre la cepa de Staphylococcus aureus y la fracción en cloroformo a la misma concentración sobre Bacillus subtilis, Pseudomona aeruginosa y Staphylococcus aureus.
Detección de la proteína core del virus de la hepatitis C y nivel de expresión de la proteína p 53 en casos de carcinoma hepatocelular
Authors: Alvarez F. Claudia M. , Arango Juan C. , Correa Gonzalo , Restrepo Juan C. , Navas María C.
Published: January 2025

El principal factor de riesgo en más del 80% de los casos de carcinoma hepatocelular, es la infección por el Virus de la hepatitis B (HB) o el de la hepatitis C (VHC). Algunos estudios sugierenque la proteína Core del VHC estaría implicada en el mecanismooncogénico del VHC, debido a la capacidad de transformacióncelular en cooperación con H-ras (1), la capacidad de regulación o de interacción proteína-proteína con p53 (2) y al desarrollo de HCC en ratones transgénicos para la proteína Core (3).
INTERACTION BETWEEN THE MEDIA AND THE POLITICAL SYSTEM IN THE CONTEXT OF DEVELOPING PUBLIC OPINION
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Sharipov Ruslan
Published: January 2025

The article focuses on the study of the relationship between the media and public opinion and the impact on decision-making in the political process. The study shows that public opinion is a kind of indicator of socio-political changes, which directly affects the editorial strategies of the media and determines the priorities for covering events and topics in the public space. The media, in turn, is an active factor in shaping public opinion, strengthening its influence on political decisions and stimulating the development of political consciousness of citizens. The author notes that one of the important aspects of the interaction between media and politics is the commercialisation of the media space, which, on the one hand, may limit the ability of the media to provide objective information due to its dependence on market interests, advertisers and economic conditions. On the other hand, commercialisation makes the media an important factor in influencing political transformations, especially in post-Soviet states undergoing complex democratic transitions. The article also examines the role of media scandals in shaping political identity, exposing violations in the actions of politicians and ensuring public scrutiny. Media scandals are becoming an important tool in political struggle, manipulation and the formation of new political alliances, and sometimes they are the reason for the resignation of high-ranking officials. At the same time, these processes are accompanied by the risk of fake news, disinformation and manipulation, which can negatively affect public consciousness and threaten national interests and information security. The author concludes that the modern media space requires careful regulation to ensure freedom of speech, media independence and protection from external pressure. Only under such conditions can the media support the development of a democratic society by providing objective information to citizens and facilitating the adoption of sound political decisions that meet the needs of society.
Phenomenon of anisotropy in the group of germanic preterite-present and inchoative verbs as a factor of analytization
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Bondarenko Valeria , Botsman Andriy ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Dmytruk Olga ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: January 2025

The purpose of this article is to find out the influence of anisotropy on the process of analytization which causes the development of the future tense forms in the Germanic languages. The analytization of temporal (the future tense in particular) forms is connected with the separation of the initial formant in the analytical morphological temporal forms. The initial formant varies in the East, West, and North Germanic languages performing one and the same function of future time preference. Comparison of different Germanic languages gives the possibility to trace the gradual analytization of verb grammatical forms, and to find out individual group features which are characteristic for preterite-present and inchoative verbs.

The subject of the research is peculiarities of the factors which cause creation of initial formants in future tense forms. On the initial stage the Proto-Germanic verb group was characterized with the feature of isotropy. The weak features of primary anisotropy appeared when preterite-present and inchoative verbs were distinguished as initial formants. Simultaneously different verb groups reflecting heterogeneization of the initial formant created the background for formant anisotropy.

Heterogeneity and anisotropy are closely connected and influence each other. Primary anisotropy has biaxial feature. The first axis is based on the preterite-present group, the second one is represented in the inchoative group. This biaxial nature is preserved as a proto-background for the whole verb system. Having passed the process of gradual grammaticalization, inchoative verb group was transformed into the tense auxiliary verbs. Preterite-present verb group was heterogenized into present and past tense sub-groups. The stage of secondary heterogenization reflected secondary anisotropy with the same biaxial structure. Differentiated present and past auxiliary verb forms preserving biaxial structure got different functions strengthening heterogeneity which caused tertiary stage reflected in the tertiary anisotropy. It established confirmed forms for the future tense and the oblique mood where initial formants gained their final functional individuality.

Heterogeneity and anisotropy are closely connected processes; they both are responsible for the analytical verb forms development in the Germanic languages giving a motive force to the further development of the whole verb morphological structure pushing it from the stage of isotropy to the position of anisotropy differentiating initial and final formants of analytical forms which brought spare flexibility to the verb system of the Middle and New Germanic languages.
Search for traces of selection by analyzing homozygous regions in a population of Chinese silk chicken breed
Authors: Reinbach Natalia R. , Dementieva Natalia V.
Published: January 2025

BACKGROUND: In China, the Chinese silkie chicken is designated as a breed of significant conservation priority, employed in both meat and poultry production, as well as in traditional Chinese medicine. The distinctive phenotypic traits, including hookless feathers, polydactyly, black skin, bones, and hyperpigmentation of connective tissue, have garnered the attention of both poultry breeders and scientific researchers, who utilize Chinese silk chickens as a model to investigate the genetic and evolutionary processes underlying genetic diversity.
AIM: Study of selection traces in the genome of the Chinese silk chicken population in Russia.
MATERIALS AND METHODS: For the purposes of this study, biological material was obtained from birds of the Russian population of Chinese silk chickens. Genotyping was conducted using the Illumina Chicken 60K SNP microarray. The analysis of genomic architecture included the study of homozygous regions with a frequency of occurrence above 75%.
RESULTS: The study selected 24 candidate genes associated with plumage development (АLK, EDARADD), the backbone (WDR43, FBXO11), and those affecting body adaptive and immune capacity (EPCAM, PELI3, PLEK, LGALS8, RAB1B, RYR2), on egg (MDH1, SPRED2, MEIS1, ACTN2, PCNX2, BCL2L10, CYP19A1), and on meat (FOXN2, B3GNT2, MDH1, TMOD3, SLC35F3, NTPCR, PPP3R1, TSNAX) performance.
CONCLUSIONS: These findings enhance our comprehension of the impact of selective breeding on the genetic makeup of the Chinese silk breed in Russia and contribute to the preservation of this distinctive breed.
Modern aspects to the management of pregnant women with chronic hypertension
Authors: Chulkov Vasily S. , Veber Viktor R. , Gasanov Mitkhat Z. , Chulkov Vladislav S. , Minina Elena E. , Nikolenko Ekaterina S.
Published: January 2025

Women with chronic hypertension (CH) are at risk of various adverse fetal/neonatal outcomes, some of which can be mitigated by appropriate pregnancy management. The risk of complications in women with CH increases with hypertension severity and organ damage. With an increase in the relative risk of these complications, the absolute risk of serious damage to target organs (heart, kidneys, brain) remains low in the absence of preeclampsia or uncontrolled hypertension. Careful monitoring of blood pressure, including the use of home monitoring of the pregnant woman herself, allows minimizing the use of medications, especially in the first trimester, according to physiological changes in blood pressure in the second and third trimesters of pregnancy and the start of antihypertensive drugs ≥140/90 mmHg.
There is no doubt that antihypertensive therapy has benefits for women with CH. However, it should be remembered that the long-term goals for treating hypertension in adults fundamentally differ from those for treating hypertension in the short term. The general principle is to gradually reduce blood pressure to avoid a significant decrease in blood flow in the uteroplacental bloodstream. The choice of an antihypertensive drug depends on the safety of the drug, the degree of increase in blood pressure, the availability of drugs, the doctor's experience, as well as side effects and contraindications. The key to managing women with CH is pre-pregnancy counseling about pregnancy risks and possible interventions to minimize these risks.
This review systematizes national and international approaches for the management of pregnant women with CH using evidence-based medicine. Modern recommendations should become the basis for personalized management and treatment of pregnant women with CH.
Short-chain fatty acids: metabolism, functions and diagnostic capacity in metabolic disorders
Authors: Ivanov A. A. , Troshina I. A. , Golubeva T. I. , Mikhailov M. S.
Published: January 2025

The purpose of this review is to analyze the role of short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, in maintaining gastrointestinal health, metabolism, and the development of metabolic diseases, including obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD).
SCFAs are produced as a result of dietary fibers fermentation by gut microbiota and play a key role in the regulation of numerous processes. Acetate, propionate, and butyrate influence glucose and lipid metabolism, insulin sensitivity, and inflammatory responses. In NAFLD and other metabolic disorders, changes in fecal and circulating SCFA levels are observed, and this fact suggests their potential as diagnostic biomarkers. Conflicting data concerning SCFA concentrations in different stages of diseases make further research necessary to understand their role in pathogenesis. The gut-liver axis and the connection with microbial metabolites, such as SCFAs, play a significant role in the development and progression of NAFLD.
SCFAs may serve as promising diagnostic markers for assessing metabolic disorders, including NAFLD, obesity, and diabetes. Their concentrations in various biological samples provide important insights into the state of gut microbiota and can aid in early diagnosis and monitoring of metabolic disease progression and cardiovascular complications.
The use of anthropomorphic robots for developing empathic disposition as a personal trait among medical university students: a literature review.
Authors: Galstyan M. S. , Arytyunov S. D. , Kharakh I. N. , Molchanov A. S. , Astashina N. B. , Baydarov A. A. , Yuzhakov A. A.
Published: January 2025

Objective. The aim of this literature review is to analyze the psychological mechanisms that influence the development of empathy in medical students through interaction with humanoid robots. This study seeks to identify the factors that contribute to the formation of empathy as a personal trait in future physicians.
Main Points. Empathy is a crucial aspect of medical practice, fostering trustful relationships between doctors and patients. Recent research indicates that humanoid robots can be an effective tool for enhancing empathetic skills in medical students. Interaction with these robots activates the same neural networks as human-to-human interactions, including the anterior cingulate cortex, the medial prefrontal cortex, and the mirror neuron system. Cognitive and affective processes, such as emotional intelligence, imitation, and behavioral modeling, play a significant role in shaping empathy. Personal characteristics, such as openness to experience and extraversion, also have a notable impact on students’ ability to empathize when interacting with robots.
Conclusion. Anthropomorphic robots can be effectively integrated into educational programs to foster the development of empathy in students. They provide a safe environment for practicing communication and technical skills, while also encouraging emotional engagement and social cognition. Further research may help refine current technologies and methodologies, allowing for a deeper understanding of the neurobiological foundations of empathy in the context of human-robot interaction.
Pain syndrome in women with osteoarthritis against the background of overweight and hypothyroidism
Authors: Koroleva Ya. V. , Tarbeeva N. S. , Smirnova E. N. , Selyanina N. V.
Published: January 2025

Objective. To evaluate pain syndrome and its relationship with clinical, laboratory and functional changes in women with osteoarthritis (OA) due to overweight and hypothyroidism.
Materials and methods. 43 women diagnosed with OA, with a body mass index (BMI) ≥ 27 kg/m2 aged from 40 to 65 were included in the study. The patients were divided into 2 groups depending on the thyroid gland function: group 1 contained 18 patients with primary medically compensated hypothyroidism, group 2 consisted of 25 patients without thyroid gland disorders.
A physical, laboratory and instrumental examination with the assessment of thyroid status (TSH, free T4, free T3) was carried out in all the patients. Indicators of phosphorus-calcium metabolism: total calcium, ionized calcium, phosphorus, parathyroid hormone, b-crosslaps were also taken into account, as well as indicators of nonspecific inflammation: C-reactive protein (CRP), Сomplete Blood Count (CBC).
The presence of OA and its severity were confirmed by the radiography of the affected joints in 2 projections. The severity of pain was determined using the visual analogue pain scale (VAS), the algofunctional Lequesne index, and with the help of the McGill questionnaire. Statistical processing was carried out by the integrated package for statistical analysis “Statistica 10”.
Results. The study revealed severe pain syndrome according to the VAS scale, the Lequesne algofunctional index and the McGill questionnaire in patients of both groups. However, pain scale scores were higher in women with compensated hypothyroidism and correlated with markers of a nonspecific inflammation, as well as with the duration of hypothyroidism, which proves that the effect of thyroid function disorders on the severity of clinical and functional changes in OA is significant.
Conclusions. Despite of drug compensation for hypothyroidism, patients with osteoarthritis and overweight have more pronounced clinical, laboratory and functional changes in the form of increased intensity of pain syndrome and decreased pain sensitivity threshold.
Coagulopathy in children with covid-19: features of the acute period of the disease and long-term consequences
Authors: Kovtun O. P. , Olenkova O. M. , Leontieva A. V.
Published: January 2025

Objective. To assess the orientation of changes in the coagulation system in children in the acute and long-term periods after COVID-19 infection.
Materials and methods. The results of the examination of children aged from 1 to 18 with confirmed COVID-19 infection were included in a cohort retrospective study conducted in order to assess the orientation of changes in the coagulation system in children in the acute and long-term period after COVID-19 infection. The set of examinations included indicators for assessing vascular-platelet (platelet count, platelet aggregation) and plasma-coagulation (INR, APTT, thrombin time, fibrinogen level, antithrombin III, SFMC, euglobulin lysis, D-dimer level) links of hemostasis. 130 children comprising the main observation group and 113 children of the control group (healthy children) were examined.
Results. It was determined that the acute period of a new coronavirus infection in children is characterized by changes in the hemostasis system, and disturbances affect all links - vascular platelet, plasma coagulation and fibrinolysis system, not depending on the severity of the infection. The changes persist within 4–4.5 months after the infection.
Conclusion. Younger children (1–5 years old) are the most alert. Both in the debut of COVID-19 and in the postcovid period, the maximum number of abnormalities was revealed in these patients and the largest number of children had these changes. The most favorable state of the blood coagulation system is determined in the older age group (children 11–18 years old). Despite the fact that the onset of the disease in children is accompanied by significant changes in hemostasis indicators, which is typical for COVID-19, in the post-ovarian period, almost all indicators reached their optimal values. The data obtained confirm the opinion that one of the complications of COVID-19 is the development of coagulopathy, which in turn can lead to thrombosis in large and small vessels, and inhibition of fibrinolysis (hypofibrinolysis) can be a predictor of thromboembolic complications. Children who have suffered a new coronavirus infection form a risk group for the development of the above-mentioned complications and require more attention, possibly follow-up for a long period after the disease.
Changes in the size of dental arches in different variants of the course of the retention period of treatment in patients with anomalies in the maxillary canines position
Authors: Rusanova D. A. , Ishmurzin P. V.
Published: January 2025

Objective. To assess the changes in the size of dental arches in different variants of the course of the retention period in patients with anomalies in the position of the maxillary canines in a long-term follow-up.
Materials and methods. An open prospective clinical and instrumental study with elements of retrospective analysis was conducted. The study included 69 patients aged 18 to 45 (median age 24,1 ± 0,9 years) in the retention period of orthodontic treatment for anomalies in the position of the maxillary canines. The duration of patients` observation was from 2 to 8 years (median duration 3,57 ± 0,24 years).
The patients were divided into groups depending on the course of the retention period. Group 1 contained patients with an unfavorable course (having a relapse of the dentoalveolar anomaly): 22 people (9 males and 13 females), average age 23,8 ± 3,4 years; group 2 included patients with a favorable course (having a clinically stable result of treatment): 47 people (19 males and 28 females), average age 22,6 ± 1,9 years.
Results. At a long-term follow-up in the retention period a common pattern of geometric changes in the dentition with various degrees of severity, was revealed in patients of both groups. The most pronounced reduction of the transverse dimensions of the dental arches was in the area of ​​the maxillary canines (–1,38 ± 0,27 mm in group 1, – 0,30 ± 0,20 mm in group 2) and upper premolars (–3,25 ± 0,52 mm in group 1, –1,27 ± 0,12 mm in group 2). The increase in the length of the anterior sections of the dental arches in individuals with the phenomena of "true relapse" was 0,95 ± 0,32 mm on the upper jaw, 0,50 ± 0,19 mm on the lower jaw, in individuals with "relapse-like movement" of teeth – 2,44 ± 0,16 mm on the upper jaw and 1,53 ± 0,24 mm on the lower jaw, in patients with a stable treatment result – 0,66 ± 0,25 on the upper jaw, 0,51 ± 0,19 mm on the lower jaw, which indicates a mutually balanced change in the transverse and sagittal parameters.
Conclusions. In the long-term observation period (2 or more years from the beginning of the retention period of orthodontic treatment), a change in the metric parameters of the dental arches is revealed in patients with anomalies in the position of the maxillary canines, which causes a recurrent change in their shape in the lateral parts. At the same time, the final values ​​of absolute increase of transverse parameters both in case of a stable result of orthodontic treatment and with a relapse of the anomaly practically have no differences.
Ultrasound-assisted quadratus lumborum block as a method of postoperative analgesia in total hip arthroplasty: a single-center prospective randomized study
Authors: Molchanov Evgenii A. , Ezhevskaya Anna A. , Ignatev Sergei M. , Baturina Ekaterina A. , Fedorov Mikhail E.
Published: January 2025

BACKGROUND: Using regional postoperative analgesia in total hip arthroplasty (THA) minimizes pain and opioid consumption while preserving patient mobility. Quadratus lumborum block (QLB) has demonstrated these effects in abdominal surgery; however, its application in trauma and orthopedics remains understudied.
AIM: To evaluate the efficacy and safety of combining lateral and posterior approaches to QLB as a component of multimodal analgesia for postoperative pain management after THA.
MATERIALS AND METHODS: This single-center prospective randomized study included 153 patients aged 48–65 years undergoing THA. Participants were divided into two groups: Group1 received preoperative QLB, while Group2 served as the control. All patients underwent spinal anesthesia with intravenous sedation and received analgesia as part of multimodal pain management. Postoperative outcomes on the first day were assessed by measuring pain intensity using the visual analog scale (VAS) at rest and during mobilization, walking distance, opioid consumption, and the incidence of side effects from opioid use.
RESULTS: VAS pain scores at 6, 12, and 24 hours postoperatively were significantly lower in the QLB group compared to the control group (p0.001). Walking distance also differed: Group1 patients walked 10 [5; 20]m within the first 12hours and 40 [30; 50]m within 24hours, compared to 5 [0; 10]m and 30 [20; 40]m, respectively, in the control group (p0.017). In Group1, 28 (50.67%) patients did not require opioids, and 37 (49.33%) needed them only once. In the control group, all patients required opioids, with 38 (50.67%) requesting repeated doses (p0.001).
CONCLUSION: This study demonstrated that QLB effectively reduces pain, opioid consumption, and associated complications while increasing mobility, confirming its efficacy and safety as a postoperative analgesic method for THA.
The efficacy of ultrasound-assisted pterygopalatine blockade by the posterior-anterior infrazygomatic approach during eye enucleation: prospective randomized comparative study
Authors: Oleshchenko Irina G. , Zabolotskii Dmitrii V. , Mankov Aleksandr V. , Koriachkin Victor A.
Published: January 2025

BACKGROUND: The pterygopalatine blockade (PPB) has broad indications in ophthalmology, which explains the possibility of simultaneous influence on sympathetic, parasympathetic and nociceptive innervation. Ultrasound navigation is widely used to control blockades, but currently there is no information on the clinical efficacy of performing ultrasound-assisted pterygopalatine blockade with different access.
OBJECTIVE: Our aim was to compare the efficacy of performing ultrasound-navigated PPB with by posterior-anterior infrazygomatic and supra-zygomatic approaches in patients after eye enucleation.
MATERIALS AND METHODS: A prospective randomized study was conducted. For postoperative anesthesia in group 1 PPB was performed using a posterior-anterior infrazygomatic approach (n=30), in group 2 (n=30) — using a supra-zygomatic approach. The time of PPB performance, the anesthesia start time, changes in blood pressure and heart rate as well as technical features of the blockade were evaluated.
RESULTS: A comparison of the time interval from the blockade performance to the anesthesia start time in the groups demonstarted that in patients of group 1 it was 5.3±1.0min., which had significant differences with the results in group 2 — 10.1±1.4min. (p=0.041). When comparing the dynamics of the onset of the analgesic effect, the PPB demonstrated that in patients of group 1, the time for the onset of anesthesia was 5.3±1.0min., compared with the results of group 2 — 10.1±1.4min. (p=0.041). A statistically significant difference was found in the time of onset of a skin sensitivity decrease in the suborbital region and the time required for a pain syndrome relief: in group 1 — 8.9±0.9min. and 13.5±0.7min., in group 2 — 14.4 ±1.2min. and 19.6±1.7min., respectively (p=0.037, p=0.034). The PPB values in patients of group 1 were 91.2±6.5mmHg significantly lower compared with the values of patients of group 2 — 101.1±6.6mmHg, respectively (p=0.001). When performing PPB by the supra-zygomatic approach (group 2), in 53.3% (n=16) of cases patients reacted to painful sensations, the average score for PPB was 2.3±0.5.
CONCLUSION: In the treatment of pain syndrome after enucleation of the eye, the method of choice is ultrasound-assisted PPB blockade by the posterior-anterior infrazygomatic approach, which, in comparison with the blockade by the supra-zygomatic approach, ensures the rapid start of effective analgesia, comfort and safety for the patient.
The Relationships between Interactional Justice, Trust, and Logistics Performance in Supply Chain Management
Authors:   The Korean Logistics Research Association, Lee Chang-Joon , Ha Young-Kyou
Published: January 2025

This study empirically analyzes the impact of justice and trust, both of which fall under the umbrella of business ethics, on the inter-company relationships within the supply chain. The study further investigates how these factors affect the quantitative performance of logistics operations. For the analysis of the research model, interactional justice was divided into interpersonal and informational justice, and trust was divided into cognitive and emotional trust. Subsequently, surveys were conducted with employees in supply chain-related departments in South Korea to explore the pathway that leads to quantitative performance. Hypotheses were then tested through structural equation modeling. An empirical analysis revealed that both interpersonal and informational justice have a significant positive impact on both dimensions of trust and that both cognitive and emotional trust positively affect logistics performance. Based on this study's results, we concluded that interactional justice and trust are key intangible assets within the supply chain that influence quantitative logistics performance. Global supply chains are rapidly changing, undergoing repeated dismantling and reorganization. In such an environment, it is challenging to assert sustainability through existing assets and practices, and the discovery of new growth drivers is gaining attention. This study proposes a new driver for the supply chain by defining justice and trust as intangible assets and deriving a method to quantify them.
A Study on Proposing Improvements to the Pharmaceutical Cold Chain Through the Analysis of Pharmaceutical Delivery Data
Authors:   The Korean Logistics Research Association, Lee Ji-Won , Lee Hyang-Sook
Published: January 2025

The pharmaceutical industry is a continuously growing industry due to the increasing demand for well-being and well-aging as the population ages, as well as the increase in chronic and new diseases. In this study, we looked at temperature deviations and identified their causes through temperature data analysis as social interest in maintaining the temperature of the cold chain for pharmaceuticals increases. The data analysis was conducted based on the data of flu vaccine from pharmaceutical company B, which is in charge of the 3PL of domestic pharmaceuticals, and the time range was limited to 2021 to 2024, and the spatial range was limited to the Cheon-an area. We looked at the temperatures that deviated from the temperature regulation range and identified the causes through on-site interviews. According to regulations, pharmaceutical products are only discarded if they have been out of the temperature range for more than an hour, but in this study, even if the temperature has been out of the range for a short time, it is judged as an outlier and analyzed. The causes of temperature deviations, such as extreme low and high temperatures, include the measurement of extreme low temperatures due to the failure to condition the insulation, the entry of cold air from the vehicle into the packaging during the delivery process, or the entry of external heat into the packaging, and the damage to the packaging and temperature measuring equipment of the delivery service. It is expected that these causes can strengthen the safety of the pharmaceutical cold chain through the problem recognition and improvement of on-site workers.
Study on the Application of Agreement Tariffs According to Changes in the Logistics Environment : Focusing on the Korea-China FTA and the Korea-Peru FTA
Authors:   The Korean Logistics Research Association, Kwon Hyuk
Published: January 2025

According to global export and import statistics as of 2023, Korea's exports to China amounted to $124.6 billion, while its imports amounted to $142.8 billion, accounting for about 20% of the total share. It was also found that the proportion of raw materials imported by Korean companies from Peru is gradually increasing. Accordingly, in order to identify the points to note in applying the agreement tariff, we analyzed the cases of review requests for the Korea-China FTA and the Korea-Peru FTA received by the Tax Tribunal&Korea Customs Service. As a result, first, it was found that Korean companies misinterpreted the FTA agreement text and were not aware of the reapplication guidelines related to the revised FTA Tariff Special Measures Act, which prevented them from receiving preferential tariffs. Second, it was found that the roles and cooperation of exporters, producers, and customs authorities of the counterpart country are important in the Korea Customs Service's country of origin verification investigation stage. Therefore, this study presents practical implications for Korean importers utilizing the FTA and Korean companies operating overseas, and proposes policy support measures to the government and customs authorities so that companies can receive preferential tariffs.
A Study on the Competitive Factors in the Courier Industry and Their Impact on Customer Satisfaction and Loyalty : Focusing on SF Express in China
Authors:   The Korean Logistics Research Association, Yuan Zhe-Hao , Yoo Byong-Kook
Published: January 2025

With the acceleration of global economic integration, the courier and logistics industry is emerging as a core sector of national economies, underscoring its growing importance. In recent years, the rapid growth of the courier market in China has spurred intense competition among global logistics companies. This competition spans various dimensions, including service quality, branding, pricing, and transportation modes. Consequently, a comprehensive analysis of these competitive factors is essential for developing sustainable strategies for courier enterprises. This study examines the impact of perceived service quality, pricing, logistics channels, and brand image on customer satisfaction and loyalty through a structural equation modeling approach, focusing on customers of SF Express, a leading courier company in China. The findings reveal that the competitive factors considered in the model—service quality, pricing, logistics channels, and brand image—all significantly influence customer satisfaction and loyalty in the courier sector.
Estudio del mucílago de semillas mutantes para conocer el papel de la arabinosa en la pared celular
Authors: Gómez de Agüero Paula , Largo Gosens Asier
Published: January 2025

La pared celular primaria rodea los protoplastos de las células de las plantas y está compuesta principalmente por celulosa, hemicelulosas, pectinas y glicoproteínas. Los dos últimos grupos poseen arabinofuranosa en sus cadenas laterales y, aunque el déficit de este monosacárido produce defectos severos en el desarrollo, todavía se desconoce su función en la pared celular. Para realizar este trabajo se ha estudiado el mucílago de las semillas de Arabidopsis thaliana, que es una estructura de fácil extracción con agua y muy rica en pectinas, lo que facilita el análisis de estos polisacáridos. Se han analizado 8 mutantes en genes RGP (RGP1-5) que codifican para un complejo enzimático encargado de catalizar el último paso en la síntesis de UDP-arabinofuranosa, precursor activado necesa- rio para la síntesis de polímeros que contienen arabinofuranosa. El estudio de los mutantes rgp reveló que la reducción de la expresión de RGP4 y RGP5 provoca un déficit en la liberación del mucílago, destacando el mutante rgp5-2. La superficie de las semillas de los mutantes rgp5-2 mostró anomalías en las células que sintetizan el mucílago, lo que podría explicar los problemas en la liberación. No obstante, es necesario seguir estudiando los genes RGP para intentar comprender mejor el rol de la arabinosa en la pared celular de las plantas.
Selección de hábitat
Authors: Ortega Zaida
Published: January 2025

El movimiento de los animales determina la eficacia biológica de los individuos, y la composición de poblaciones, comunidades y ecosistemas, condicionando también fenómenos como la transmisión de enfermedades y parásitos, la polinización o la dispersión de semillas. Por eso es clave comprender las causas y consecuencias del movimiento animal. Este artículo pretende ser una introducción para quien quiera trabajar en movimiento animal, y, más concretamente, en selección de hábitat. Para ello, he resumido el marco teórico de la ecología del movimiento y sus principales métodos y temáticas de estudio: análisis de trayec- torias, estudio de los patrones de movimiento y las áreas de campeo y selección de hábitat. A continuación, explico el marco teórico de la selección de hábitat, ilustrando los principales métodos de estudio con algunos estudios de caso específicos sobre reptiles y mamíferos. Al final, discuto las principales ventajas decada método de estudio en selección de hábitat.
Pathological complete response after neoadjuvant immunochemotherapy in gastric cancer with microsatellite instability without PD-L1 expression (CPS = 0). A case report
Authors: Nered S. N. , Dzamaliddinova R. N. , Sun H. , Tryakin А. А. , Kononets P. V. , Stilidi I. S.
Published: January 2025

Despite the use of modern treatment methods for gastric cancer (GC), survival rates in locally advanced stages remain unsatisfactory. This necessitates the search for new therapeutic options and potential predictive factors for tailoring treatment approaches. The emergence of new molecular classifications like The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG), leading to the identification of a distinct subset — gastric cancer with high microsatellite instability (MSI-H) caused by mismatch repair deficiency (dMMR), has paved the way for a novel treatment direction: immunotherapy. MSI status and PD-L1 expression are regarded as predictors of immunotherapy efficacy in GC. However, the question of which marker is more accurate or if they should be considered together remains unanswered. Furthermore, the efficacy of checkpoint inhibitor therapy is often attributed to increased PD-L1 expression in microsatellite unstable tumors compared to microsatellite stable ones. The article discusses a case demonstrating the high efficacy of immunochemotherapy, resulting in complete pathomorphological regression of the tumor in a patient with locally advanced gastric cancer and MSI-H status after neoadjuvant immunochemotherapy, despite the absence of PD-L1 expression (CPS-0). The patient has been monitored for 1.5 years post-treatment at the N. N. Blokhin National Medical Research Center of Oncology without signs of progression.
The Role of Cybersecurity in Safeguarding Cross-Border E-Commerce and Economic Growth
Authors: Kamisetty Arjun
Published: January 2025

This research examines how cybersecurity protects cross-border e-commerce and boosts economic development. With digital commerce growing rapidly, the study examines how strong cybersecurity standards affect customer trust, corporate resilience, and international trade. The research analyzes cybersecurity issues, new technologies, and their economic effects on cross-border e-commerce using secondary data from peer-reviewed journals, industry reports, and regulatory papers. Secure digital platforms are crucial to customer trust, and strong cybersecurity policies may limit financial risks, facilitate corporate innovation, and help SMEs in global marketplaces. Artificial intelligence, blockchain, and sophisticated encryption improve cybersecurity and secure e-commerce platforms. The report also highlights legislative fragmentation and the need for international collaboration to standardize cybersecurity standards. Governments must create collaborative frameworks, encourage firms to embrace cutting-edge security solutions and promote digital literacy to raise consumer awareness. Businesses and governments can build a safe digital trade environment that boosts economic development, minimizes risks, and opens new global commerce possibilities by closing cybersecurity gaps.
What Women Intercollegiate Coaches Say
Authors: Boucher Courtney , LaVoi Nicole M.
Published: January 2025

To address misconceptions about the lack of women in sport coaching, factors
influencing intercollegiate women coaches' career decisions, including their choices to
leave positions, apply for new ones, and accept or deny job offers were explored.
Utilizing a multi-level analysis underpinned by critical feminist theory, a
comprehensive understanding of the systemic and structural barriers women coaches faced,
as well as the strategies they employed to navigate their careers were illuminated. Key
findings revealed that unequal pay, lack of administrative support, insufficient
resources, and pervasive gender biases significantly impacted women's career choices.
The importance of supportive workplace environments, flexible working conditions,
professional development opportunities, and organizational commitments to diversity and
inclusion emerged as crucial for attracting and retaining women coaches. By gathering
women coach’s perspectives (n = 118, NCAA Division I, II, and III), data refuted common
‘blame the women’ narratives and emphasized the need for systemic change within
intercollegiate sports. This research contributed to the ongoing dialogue on gender
equity and practical strategies for athletic departments to create more inclusive and
supportive environments, thereby enhancing the recruitment and retention of women
coaches are offered.
Pengaruh Double Chamfer Terhadap Kekuatan Tarik Dan Struktur Mikro Pada Hasil Sambungan Las Gesek Al 6061
Authors: Priambudi Andi , Dirja Iman , Hanifi Rizal
Published: January 2025

Aluminum, with a thermal conductivity close to 2/3 that of copper, can utilize friction welding effectively. Chamfer angles improve the welding quality by increasing the generated heat, resulting in higher mechanical properties. This study investigates the impact of chamfer angles (15°, 30°, and 45°) on the microstructure and tensile strength of friction-welded Al 6061 under conditions of 1600 rpm rotation, 50 MPa forging pressure, 20 MPa friction pressure, and 45 seconds of welding time. Microstructure and tensile strength tests were conducted on three specimens for each chamfer angle. Results show that increased friction time, friction pressure, and forging pressure lead to greater material loss due to flash formation. Microstructure analysis revealed that chamfer angles of 30° and 45° achieved better welding at the interface due to sufficient heat generation. In the heat-affected zone (HAZ), all angles (15°, 30°, and 45°) showed phase structure changes, with broader and more uniform Mg2Si and Fe3SiAl12 phases, attributed to the cooling process and relatively low heat. Tensile testing showed the highest tensile strength (177.9 MPa) and strain (6.42%) for the 30° chamfer angle, outperforming the 15° and 45° angles. The smallest strain (3.72%) was observed in the 15° chamfer angle, indicating the significant influence of chamfer geometry on friction welding outcomes.