bluuebunny/crossref_metadata_2025 huggingface dataset:
Hubungan kebiasaan sarapan dengan indeks massa tubuh pelajar SMP Negeri 1 Long Bangun Mahakam Ulu
Authors: Faridawati Hety , Darmawi Kumala Dewi
Published: February 2025

Asupan gizi dimulai dari aktivitas sarapan. Sarapan berperan penting dalam pemenuhan kebutuhan zat gizi yang berguna dalam proses fisiologis pada tubuh. Namun, seringkali siswa mengabaikan sarapan pagi. Sarapan juga memberikan berpengaruh terhadap konsentrasi pada saat belajar karena otak akan sulit untuk berkonsentrasi jika tubuh kekurangan asupan nutrisi. Sarapan dikatakan dapat mengurangi obesitas dan mendukung status gizi yang lebih baik. Studi ini bertujuan untuk melihat hubungan kebiasaan sarapan dengan indeks massa tubuh (IMT) pada pelajar SMP Negeri 1 Long Bagun. Studi analitik ini dilakukan terhadap 184 orang pelajar yang diambil secara consecutive non random sampling. Data diambil menggunakan kuesioner dan pengukuran berat badan dan tinggi badan untuk penentuan status gizi. Pelajar SMPN 1 Long Bangun paling banyak memiliki kategori kebiasaan sarapan yang jarang (85 pelajar; 46,2%) dan memiliki IMT berlebih (95 pelajar; 51,6%). Hasil studi menunjukkan bahwa kebiasaan sarapan berkorelasi dengan indeks massa tubuh (IMT) pada pelajar (p = 0,0005). Sarapan pagi rutin setiap harinya sebelum berangkat sekolah dapat disiasati dengan menyiapkan terlebih dahulu menu makanan yang akan dikonsumsi pada waktu malam hari agar tidak terburu-buru saat pagi harinya, khususnya mengkonsumsi makanan yang bergizi seimbang sesuai kebutuhan pelajar.
Pengaruh durasi dan posisi mengetik terhadap gejala Carpal Tunnel Syndrome pada karyawan Universitas Tarumanagara
Authors: Sitorus Ribka Anggeline Hariesti , Setiadi Tjie Haming
Published: February 2025

Carpal Tunnel Syndrome (CTS), kumpulan gejala yang terjadi akibat adanya tekanan yang diberikan oleh terowongan karpal pada saraf medianus di pergelangan tangan, sering dialami oleh pekerja yang mengetik dalam durasi lama dengan posisi tidak ergonomis. Studi ini bertujuan menganalisis pengaruh durasi dan posisi mengetik dengan insiden gejala CTS pada karyawan Universitas Tarumanagara. Studi analitik dengan desain cross-sectional dilakukan terhadap 145 responden yang dikumpulkan melalui metode non-random sampling.  Instrumen yang digunakan berupa kuesioner dan pemeriksaan fisik untuk mendeteksi CTS. Hasil studi menunjukkan 30 (20,7%) responden mengalami gejala CTS, sementara 115 (79,3%) tidak mengalami CTS. Mayoritas responden mengetik lebih dari 55 menit per hari tanpa jeda (134; 92,4%), dengan 98 (67,6%) responden diantaranya mengetik dengan posisi yang tidak ergonomis. Analisis risiko menunjukkan bahwa durasi mengetik lama meningkatkan risiko CTS hingga 2,38 kali (PRR = 2,38), sementara posisi mengetik yang tidak ergonomis meningkatkan risiko CTS hingga 3,12 kali (PRR = 3,12). Meski analisis menunjukkan tidak ada hubungan signifikan antara durasi mengetik dan gejala CTS (p-value = 0,460), namun terdapat hubungan signifikan antara posisi mengetik yang salah dan gejala CTS (p-value = 0,012). Temuan ini menekankan pentingnya praktik ergonomis, seperti penyesuaian posisi mengetik dan pengambilan jeda dalam upaya mencegah CTS di lingkungan kerja, terutama pada karyawan yang sering menggunakan komputer.
Implementasi Manajemen Transportasi Publik Di Provinsi DKI Jakarta(Studi Kasus Integrasi Antar Moda Angkutan Darat)
Authors: Pratomo Wisnu Budhi , Hertasning Bram , Fidilia Shaula , Anggraeni Devi
Published: February 2025

Kemacetan lalu lintas di DKI Jakarta saat ini semakin luas baik dari aspek ruang maupun aspek waktu dan bahkan kemacetan pun sudah merambah ke wilayah penyangga. Tidak hanya jalan protokol saja yang mengalami kemacetan, namun sudah masuk ke jalan lingkungan. Pertumbuhan kendaraan pribadi yg pesat tidak diimbangi dengan jumlah pertumbuhan jalan. Disamping itu, baik Pemerintah Pusat maupun Pemerintah Provinsi DKI Jakarta belum menunjukkan upaya jangka panjang untuk mencegah terjadinya kecamatan dan hanya berfokus pada mengatasi kemacetan. Tujuan dari penelitian ini adalah mendeskripsikan bagaimana implementasi manajemen transportasi publik di Provinsi DKI Jakarta, mengetahui apa saja faktor pendukung dan faktor penghambat optimalisasi manajemen transportasi publik di Provinsi DKI Jakarta guna menangani masalah publik yang berkaitan dengan aspek transportasi, dan memberikan alternatif atau solusi perbaikan dalam upaya untuk mewujudkan kemajuan pelayanan publik di sektor transportasi di Provinsi DKI Jakarta. Penelitian ini dilakukan dengan pendekatan kualitatif dan bersifat deskriptif dengan alat pengumpulan data yaitu wawancara secara mendalam. Hasil yang didapat adalah dari sisi Implementasi manajemen transportasi publik di Provinsi DKI Jakarta telah menunjukkan progress yang baik, akan tetapi masih memerlukan peningkatan dalam beberapa aspek, seperti perluasan jaringan, integrasi moda transportasi, dan peningkatan koordinasi antar pemangku kepentingan dan birokrasi dan regulasi menjadi faktor pendukung dan penghambat dalam upaya optimalisasi manajemen transportasi publik.
Prominin 2 knockdown inhibits the growth, migration, and invasion of non-small cell lung cancer cells by repressing phosphatidylinositol 3 kinase/protein kinase B pathway
Authors: He Biao , Chen Ze , Zhong Liang , Pang Xiaoyong
Published: February 2025

Objective

The prognosis of patients with non-small cell lung cancer (NSCLC) is poor, and this malignancy represents a grievous danger to human health due to its high rates of recurrence and metastasis. Previous studies have linked prominin 2 (PROM2) to certain cancers. However, the impact of PROM2 on the biological behavior of NSCLC cells and regulatory pathways has rarely been explored. Therefore, the study aims to elucidate the roles and regulatory mechanisms of PROM2 in the cell function of NSCLC by interfering with PROM2.

Material and Methods

PROM2 messenger ribonucleic acid (mRNA) and protein expression levels in NSCLC cells were analyzed by applying quantitative real-time polymerase chain reaction and Western blot analysis. Phosphatidylinositol 3 kinase (PI3K), protein kinase B (AKT), and phosphorylated-AKT (p-AKT) protein levels were evaluated through Western blot analysis. Cell counting kit-8 and Transwell assays were used to evaluate NSCLC cell proliferation, migration, and invasion.

Results

PROM2 mRNA protein levels drastically increased in NSCLC tissues and cells. High PROM2 mRNA level was related to the poor prognosis of patients with NSCLC. PROM2 silencing remarkably repressed NCI-H520 and A549 cell proliferation, migration, and invasion. Furthermore, PI3K and p-AKT protein levels clearly decreased after PROM2 silencing. Importantly, rescue experiments elucidated that PI3K/AKT pathway activation could reverse the inhibitory effect of PROM2 silencing on the proliferation, migration, and invasion of NCI-H520 and A549 cells.

Conclusion

This study verified that PROM2 knockdown inhibits the growth, migration, and invasion of NSCLC by repressing the PI3K/AKT pathway.
Seal and heal: A novel deal for periungual wart
Authors: Gupta Sanjeev , Jangra Ravi Shankar , Dabhra Aditi , Gupta Namya
Published: February 2025

Periungual warts are a common yet challenging dermatological condition, often resistant to conventional treatments due to various factors that make these warts notoriously resistant to conventional treatment. We propose an innovative solution to this problem.
Clinical case of traumatic dislocation of the eyeball
Authors:   GBUZ RB Maloyazovskaya Central District Hospital, Maloyaz, Russia, Gufranova D.K.
Published: February 2025

The article presents a rare clinical case of dislocation of the right eyeball in patient P., 46 years old, as a result of a domestic injury. Within 30 minutes after the injury, the patient was taken to the hospital, where she underwent all the necessary examinations and consultations with a surgeon, neurologist, and therapist, and within 6 hours she was provided with surgical emergency medical care. The latter was carried out in 2 stages: in the first stage, reposition of the eyeball was performed with blepharorrhaphy and a pressure bandage, and in the second stage, a week later, a reconstructive operation was performed with revision of the conjunctival cavity, followed by its plastic surgery, isolation and dissection of scar adhesions of the rectus muscles, suturing of torn ones and shortening of stretched ones. extraocular muscles, etc. The patient’s combined injury, representing a combination of brain contusion and patellar fracture with prolapse of the eyeball, hemophthalmos and retinal detachment, necessitated complex therapy and low visual acuity at discharge (0.01 does not correct). In the future, the patient is scheduled for vitreoretinal surgery.

Key words: traumatic dislocation of the eyeball, hemophthalmos, retinal detachment, eye reposition with blepharorrhaphy, reconstructive surgery
Les cartographies de parcours et leurs usages : revue systématique de la littérature
Authors: Yönder Çiğdem , Hamarat Yaprak , Elsen Catherine
Published: February 2025

La cartographie d’une activité et sa visualisation sous forme de parcours constituent une méthode de plus en plus fréquemment utilisée pour comprendre et matérialiser l'expérience des usagers. Alors que les processus sollicités pour construire ces cartographies sont bien documentés dans la littérature actuelle, les usages du produit final de ces processus (à savoir les visualisations des données recueillies sous forme de cartographies) ne sont quant à eux pas largement étudiés. À travers cette revue de la littérature, nous ambitionnons de croiser les avancées scientifiques les plus récentes et de discuter la diversité de ces usages, adressant les potentialités et limites des cartographies en tant qu'outil de visualisation de l’activité. Pour ce faire, nous avons extrait d’une analyse systématique de la littérature un ensemble de 11 articles issus de Scopus, publiés en langue anglaise jusqu’en 2022. Au terme de l’analyse, nous identifions sept principaux usages des cartographies de parcours, à savoir: 1) le partage des informations; 2) l’incitation au changement et à la transformation; 3) la communication; 4) l'idéation; 5) la participation et l’implication; 6) la planification et 7) la collecte de données.
An Oxidative Palladium-Catalyzed Remote meta–Selective Homo-Biaryl-Coupling Assisted by Nitrile Directing Templates
Authors: Sreenivasulu Chinnabattigalla , Ramesh Perla , Ravi Kishore Dakoju , Srinivas Dasari , Satyanarayana Gedu
Published: February 2025

Remote meta-C–H functionalization has emerged as a transformative approach in organic synthesis, allowing the selective functionalization of inactivated meta-C–H bonds. While considerable progress has been made in meta-C–H functionalization strategies, including olefination, cyanation, acetoxylation, and arylation, however, the regioselective meta-C–H homo-biaryl coupling remains unexplored. In this study, we report the first palladium-catalyzed oxidative protocol for regioselective meta-C–H homo-biaryl coupling, targeting substrates such as 3-phenylpropanoic acid, 2-phenylethan-1-ol, phenylacetic acid, and phenylmethane sulfonic acid derivatives. This method significantly enhances the synthetic toolbox for constructing complex biaryl frameworks with exceptional precision. The reaction proceeds efficiently under ambient conditions, with copper trifluoromethanesulfonate identified as a critical additive for driving the process. Furthermore, this strategy has been extended to the synthesis of complex trimeric and diolefination products. The protocol delivered the desired products in good yields with excellent regioselectivity and demonstrated broad applicability across a range of substrates bearing diverse aliphatic and aromatic nitrile-based directing group templates.
Spatially Resolved In Situ HERFD-XANES studies of ZnS Nanoparticle Synthesis at the Water-Toluene Interface
Authors: Klemeyer Lars , Caddeo Francesco , Gröne Tjark L.R. , Harouna-Mayer Sani Y. , Jessen Brian , A. Zito Cecilia , Kopula Kesavan Jagadesh , Dippel Ann-Christin , Igoa Saldaña Fernando , Mathon Olivier , Glatzel Pieter , Koziej Dorota
Published: February 2025

A two-phase synthesis has been well established for achieving precise control of nanoparticle properties. However, studying and understanding chemical transformation in such a spatially heterogeneous system is challenging. In this work, we introduce a two-phase synthesis route for ZnS nanoparticles (ZnS NPs) at the water-toluene interface. By employing spatially resolved in situ high-energy resolution fluorescence-detected X-ray absorption spectroscopy (HERFD-XAS) combined with density functional theory (DFT) calculations, we track the diffusion of Zn²⁺ species at the interface, identify key reaction intermediates, and monitor the nucleation and growth of ZnS NPs within the toluene phase. We propose the formation of a [Zn(H2O)¬6]2+ complex upon dissolving Zn(Ac)2 in water and the diffusion of Zn2+ ions from water to toluene driven by the formation of an octahedral [Zn(OA)6]2+ complex (OA = oleylamine). Furthermore, by complementing HERFD-XAS with total X-ray scattering analysis, we show the formation of an intermediate tetrahedral [Zn(SR)4]2+ complex at 60 °C and its successive transformation to non-crystalline ZnS nuclei at 80 °C and crystalline ZnS NPs starting at 100 °C. Thus, we demonstrate how in situ X-ray spectroscopy can elucidate the coordination and diffusion of Zn²⁺ ions, and, in combination with X-ray scattering studies, identify the emergence of atomic and electronic structures during the two-phase synthesis of ZnS nanoparticles.
Spontaneous Perovskite Passivators Effectively Combined with PTAA Hole Transport Materials in Perovskite Solar Cells
Authors: Nishimura Naoyuki , Kanda Hiroyuki , Murakami Takurou N.
Published: February 2025

Perovskite solar cells (PSCs) utilizing poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine (PTAA) as hole-transport materials (HTMs) in n-i-p structures have promising thermal stability compared with those employing Spiro-OMeTAD—the most widely used HTM. However, PTAA-based PSCs often exhibit lower efficiencies than their Spiro-OMeTAD counterparts, presumably due to the absence of perovskite passivation techniques suitably employed to PTAA HTMs. In this study, phenylalkylammonium bis(trifluoromethylsulfonyl)imide (PRA-TFSI) was developed as a spontaneous perovskite passivator specifically tailored for PTAA HTMs. The influence of alkyl chain lengths in PRA cations was systematically explored using newly synthesized PRA-TFSI with carbon chain lengths ranging from 1 to 4: benzylammonium-TFSI (Bn-TFSI: C1), phenylethylammonium-TFSI (PEA-TFSI: C2), phenylpropylammonium-TFSI (PPA-TFSI: C3), and phenylbutylammonium-TFSI (PBA-TFSI: C4). During the deposition of PTAA solutions containing PRA-TFSIs on perovskite photoabsorbers, spontaneous perovskite passivation formed monolayer-like overlayers, offering thermal stability at 85 ℃. This approach contrasts with conventional iodide salt-based passivation techniques, which mostly generate two-dimensional perovskites (e.g., (PEA)2PbI4) under thermal stress, potentially degrading photovoltaic performance. Notably, longer alkyl chains in PRA cations more effectively suppressed defects on perovskite surfaces owing to their accessibility to the physically deeper defects, which is a unique trend exhibited by PRA-TFSIs. Additionally, the resulting passivation layer enhanced the interfacial affinity between PTAA and the perovskite layer, likely owing to π-π interactions facilitated by the phenyl moiety in PRA cations, except for PBA-TFSI, because its long alkyl chain weakened the affinity. Among the PRA-TFSIs, PPA-TFSI (C3) emerged as the optimal passivator, achieving a power-conversion efficiency of up to 23.2%, which is high among PTAA-based PSCs with n-i-p structures—particularly among those that are Li-free, not subjected to post-passivation, and possesses substantial PTAA attachment on perovskite layers —with retention of the prominent thermal stability at 85 ℃. This study advances monolayer-like perovskite passivation technics, allowed by the spontaneous passivators, and highlights the potential of PTAA-based PSCs.
Near-zero Thermal Expansion in Coordination Polymer Cd(1,2,4-triazole)2(H2PO4)2
Authors: Sarkar Sounak , Brummerstedt Iversen Bo
Published: February 2025

Zero thermal expansion is a rare but desirable physical property for materials. Here, we report an unprecedented near-zero thermal expansion (nZTE) behavior in a two-dimensional coordination polymer (CP) Cd(1,2,4-triazole)2 (H2PO4)2 (Cd-Tz) across a broad temperature range of 25 K - 400 K. Using multi-temperature high-resolution single-crystal X-ray diffraction, we investigated the structural dynamics of the wine-rack-like framework of Cd-Tz and compared it with that of positive thermal expansion (PTE) CPs Zn-Tz and Mn-Tz with similar framework topology. We show that nZTE in Cd-Tz is a consequence of two monotonic and opposing trends with PTE (a, c ~ 22 MK-1) in the ac plane and negative thermal expansion (NTE) in the b direction (b ~ -47 MK-1). A new mechanism for the uniaxial NTE is established based on concerted out-of-plane single atom libration of similarly oriented adjacent triazole rings in the wine-rack motifs. X-ray electron density analysis and modelling of low-temperature vibrational anharmonicity reveals the role of Cd-triazole bonds and hydrogen bonds in promoting the single atom libration. Tuning the metal−ligand bonding strength through minor doping of Zn/Mn (~8/12 %) in the Cd-Tz lattice results in a prominent shift from nZTE to NTE behavior in the solid solution phases.
Evaluation of the effectiveness of revascularization in coronary artery disease according to dynamic PET/CT of the myocardium with 13N-ammonium
Authors: Golukhova Elena Z. , Aslanidis Irakliy P. , Shurupova Irina V. , Shakhova Anzhelika A. , Rumyantseva Margarita G. , Ekaeva Irina V. , Trifonova Tatiana A.
Published: February 2025

Aim. To evaluate the impact of percutaneous coronary intervention (PCI) on global and regional myocardial blood flow (MBF) parameters obtained by positron emission tomography (PET) in patients with stable coronary artery disease (CAD).
Materials and methods. Fifty-seven patients with stable form of CAD were enrolled in this study: among them 32 had obstructive CAD (70% stenotic lesion in one or more coronary artery) and were underwent PCI; 25 patients were treated conservatively. All patients underwent serial dynamic PET scan: before and after PCI as well as in follow up after medical treatment only. Rest and stress emission data were obtained; semiquantitative analysis (SSS, SDS) was performed as well as absolute MBF assessment per patient and per vessel basis and included MBF at rest and stress and myocardial flow reserve (MFR).
Results. There was an overall significant reduction in ischemia after PCI: SSS 15.0 (8.8; 20.3) before and 7.0 (3.8; 12.3) after the procedure, SDS 10.0 (7.8; 15.0) before and 4.5 (1.8; 7.0) in follow up (p0.001) and significant improvement in global stress MBF (р0.001) and MFR (р=0.002) values. In vascular territories after PCI regional values of stress MBF and MFR significantly increased (р0.001 and р=0.002 respectively), while in remote areas significant increase observed only for stress MBF (р=0.004) without change for MFR (р=0.063). Change in absolute terms for stress MBF was more apparent in PCI-regional than in remote areas – 0.37 (0.05; 0.67) ml/g/min vs 0.15 (-0.14; 0.52) ml/g/min; р=0.019.
Conclusion. After PCI apparent improvement of global perfusion in terms of semiquantitative and quantitative metrics was obtained, while no significant changes were observed in the medical treatment group. Positive changes of stress MBF values were in coronary PCI-territories as well as in remote areas. Increase of MFR observed in coronary PCI-territories only.
Phenotypic clusters and biomarkers profile in patients with chronic heart failure with preserved and mildly reduced left ventricular ejection fraction
Authors: Dragomiretskaya Natalia A. , Tolmacheva Anastasia V. , Ivannikov Alexander A. , Shvedov Ilya I. , Belyakov Artyom V. , Agalarova Kamila R. , Podzolkov Valery I.
Published: February 2025

Aim. To study the profile of cardiac biomarkers (NT-proBNP – N-terminal pro-brain natriuretic peptide, sST2 – soluble growth stimulation expressed gene 2, galectin-3, copeptin) in clusters of patients with chronic heart failure with preserved (CHFpEF) and mildly reduced (CHFmrEF) left ventricular (LV) ejection fraction (EF).
Materials and methods. The study included 135 patients with CHF and LV EF40%. All patients signed informed consent.
Results. Patients in the study were of senior age – 76 [65; 82] years; 56% are women. The most common comorbid diseases were hypertension and ischemic heart disease, including previous AMI, CKD, obesity and AF. During the cluster analysis, 4 clusters were identified: 1 – “ischemic”, in which men aged 64 [57.5; 76.3] years old with coronary artery disease and previous myocardial infarction and COPD. 2 – “hypertensive”, represented by elderly women 80.0 [74.3; 85.5] years old with arterial hypertension. 3 – “maladaptive with multiple organ disorders” – represented by elderly women with AF, signs of pulmonary hypertension, lower LV EF (48 [43; 54]%) and CKD. 4 – “cardiometabolic” – included female patients aged 71 [60.0; 78.0] years old, with obesity and type 2 diabetes, CKD and AF. In patients of cluster 3 there were higher concentrations of NT-proBNP (1640 [746; 2218] pg/ml; p=0.0015), sST2 (25.2 [17.0; 54.5] ng/ml) and galectin-3 – 11.8 [9.5; 14.3] ng/ml and the highest one-year mortality rate – 33.3%.
Conclusion. Four distinct clusters of CHF with LV EF40% patients were identified that differed in clinical characteristics, heart failure biomarkers and prognosis: ischemic, hypertensive, cardiometabolic and maladaptive with multiple organ dysfunction. These results confirm the heterogeneity of CHFpEF and CHFmrEF and create the prerequisites for the development of personalized approaches to therapy.
Comparison of long-term and short-term antiplatelet therapy after endovascular closure of patent foramen ovale: a meta-analysis of clinical trial data
Authors: Tereshchenko Andrew S. , Merkulov Evgeny V. , Chashchin Mikhail G. , Grishin Nikita S. , Strelkova Anna V. , Azimova Makka R. , Komarov Andrey L.
Published: February 2025

Background. Administration of antiplatelet therapy (APT) is the basis for the prevention of thrombotic complications after endovascular closure of patent foramen ovale (PFO). The 2018 European consensus document on the management of patients with PFO recommended long-term APT. Dual antiplatelet therapy was prescribed for 6 months followed by acetylsalicylic acid (ASC) monotherapy for up to 5 years. Subsequent clinical trials demonstrated a trend towards shorter APT due to the risk of ASC-associated bleeding. In 2022, the SCAI society recommended limiting the duration of APT to 5 months. However, the evidence base is insufficient.
Aim. To compare the efficacy and safety of shortened and prolonged APT regimens after endovascular closure of PFO.
Materials and methods. Data were searched for the period from January 2017 to May 2024. The primary endpoint was defined as the development of recurrent ischemic stroke (IS). The development of major bleeding was selected as the secondary endpoint. The combined endpoint (CEP) included all-cause death, IS, transient ischemic attack, peripheral thrombosis, myocardial infarction, and major bleeding.
Results. Eighty-nine sources were analyzed, of which 3 studies with a total sample of 1870 patients were included in the meta-analysis, which included 731 and 1139 patients with shortened and prolonged APT, respectively. Fatal outcome was recorded in 7 patients receiving abbreviated APT and 6 patients receiving prolonged APT. Patients in both groups had a comparable risk of mortality (RR 1.97; 95% CI 0.59–6.57; p=0.24; I2=29%). Similar results were obtained for the risk of TIA (RR 1.02; 95% CI 0.43 to 2.42; p=0.41; I2=0%), for the risk of IS (RR 1.01; 95% CI 0.41–2.49; p=0.59; I2=0%), and for minor bleeding (RR 0.81; 95% CI 0.49–1.34; p=0.24; I2=29%). CEP was achieved in 26 patients receiving abbreviated APT and 39 patients receiving prolonged APT; the risk of CEP did not significantly differ between combined endpoints (RR 1.04; 95% CI 0.63–1.72; p=0.15; I2=48%).
Discussion. The results of the meta-analysis showed that there was no statistical difference between abbreviated and prolonged APT in terms of efficacy and safety, which is consistent with previous clinical studies.
Conclusion. Abbreviated APT can be considered as the strategy of choice in patients at high risk of bleeding and in the absence of risk factors for thromboembolism. Conducting new studies will make it possible to accurately determine the duration of APT and develop clinical recommendations with a convincing evidence base.
Combination of statin and ezetimibe in the post-infarction period
Authors: Oleynikov Valentin E. , Salyamova Ludmila I. , Sherbinina Anastasia V. , Golubeva Alena V. , Alimov Nikolai V.
Published: February 2025

Aim. To study the lipid-lowering and pleiotropic effects of statin monotherapy and combination with ezetimibe in patients in the postinfarction period, depending on the achievement of the target level of low-density lipoprotein cholesterol (LDL cholesterol) for 24 weeks.
Materials and methods. 114 patients with myocardial infarction were included. Treatment was started with statin monotherapy, with insufficient efficacy, ezetimibe was added. After 24 weeks, the 1st group included 38 people, the 2nd – 76 patients. On 7–10th days and 24 weeks later, the lipid profile, the N-terminal fragment of the precursor of the cerebral natriuretic peptide (NT-proBNP) were determined, speckle-tracking echocardiography, ultrasound examination of the carotid arteries (CA) with RF technology were performed.
Results. At week 24, the patients were divided depending on the achievement/non-achievement of the LDL cholesterol target. The highly effective therapy group (HET) included 52 patients, the insufficiently effective therapy group (IET) consisted of 62 people. The ratio of the chances of achieving LDL cholesterol with the addition of ezetimibe to a statin was 3.4 [1.8; 6.6] (p0.001). In the HET group, by the 24th week, NT-proBNP decreased by 59.6% (p=0.045); in the IET group – by 52.2% (p=0.042). According to echocardiography data, after 24 weeks in the HET group, an increase in global constructive work GCW by 9.1% (p=0.036) and the global work index GWI by 8.2% (p=0.041) was revealed without dynamics of indicators in the comparison group. In the study of the CA, the thickness of the intima-media complex in the HET and IET groups regressed by 9.5% and 6.8% respectively (p0.05). Only in the HET group did the common CA stiffness indicators improve.
Conclusion. The achievement of LDL cholesterol control on the background of combined lipid-lowering therapy in patients in the postinfarction period is characterized by the most pronounced organoprotective effect.
A clinical case of treatment of recurrent inoperable locally advanced breast cancer using conformal radiotherapy. Case report
Authors: Medvedev Sergey V. , Vlasova Maria Yu. , Bolotina Larisa V. , Kaprin Andrey D. , Khmelevskiy Evgeny V. , Zikiryakhodzhaev Aziz D. , Khakimova Shakhnoz G. , Khakimova Gulnoz G. , Bychkova Natalya M. , Zaitseva Natalia A. , Abushova Elnara R. , Guseva Svetlana D. , Maslov Egor D.
Published: February 2025

Despite advances in the early diagnosis of breast cancer (BC), the identification of locally advanced forms continues to be relevant. This is a complex category of patients whose treatment includes the complex use of various methods with significant medical and economic costs, long-term treatment and rehabilitation. A particular difficulty is the treatment in cases of progression of locally advanced forms. Patients with locally advanced BC require a multidisciplinary approach. In the absence of an effect after neoadjuvant drug treatment and the impossibility of performing surgical intervention, patients are treated with induction radiation therapy. The article describes the features of induction radiation therapy in the treatment of progression of primary inoperable BC in a specific clinical example. In case of recurrence of triple negative type of BC, the patient underwent various drug treatment regimens with the inclusion of immunotherapy. Due to the lack of effect from 3 lines of systemic drug treatment, it was decided to conduct radiation therapy. In connection with the identified carrier of a mutation in the BRCA1 gene, targeted therapy with PARP inhibitors was prescribed. Two months after radiation therapy and 1 month after the start of targeted therapy, the patient showed complete resorption of the tumor conglomerate on the anterior chest wall. The use of conformal radiation therapy in case of recurrence of the disease and the absence of the effect of systemic treatment made it possible to completely resorb an exophytic tumor with ulceration and achieve remission within the next 6 months.
Prognostic significance of androgen receptor expression in triple-negative breast cancer
Authors: Panchenko Ivan S. , Panchenko Sergei V. , Sharafutdinov Marat G. , Rodionov Valerii V. , Kometova Vlada V. , Burmenskaya Olga V.
Published: February 2025

Background. Determining androgen receptor (AR) expression in triple-negative breast cancer (TNBC) is a promising tool in oncology.
Aim. To identify the correlation of AR expression with the clinical and genetic characteristics of the tumor and the disease prognosis.
Materials and methods. The study included 246 subjects with TNBC treated at Ulyanovsk Regional Oncological Clinical Dispensary and Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology (Moscow) from 2014 to 2024. The AR expression was determined by immunohistochemical method in all patients. Clinical (age, primary tumor size, number of regional lymph nodes affected, total malignancy score) and genetic (expression level of 44 genes expressed on the ln-scale) tumor parameters were analyzed. Parametric (Student's t-test) and non-parametric (one-way ANOVA) statistical methods were used to evaluate the relationship between AR expression and clinical genetic parameters. An overall survival analysis was performed using Kaplan–Meier curves to determine the prognosis.
Results. A log-rank test was used when comparing survival curves. Differences between groups were considered statistically significant at p0.05. AR expression is associated with elderly age, metastatic lesions of regional lymph nodes, with the expression of CTSL2, AURKA, KRT5, CCND1, BCL2, FGFR4, TMEM45A, MiKI67, MYBL2, CDKN2A, FOXA1, SFRP1, PTEN, CD68, EMSY, GATA3, EXO1, PPP2R2A, TPX2, PAK1, PTTG1, UBE2T, KIF14, CCNB1, BAG1, TMEM45B, MYC, MIA, BIRC5, PD-L1, TRAC, ZNF703, TYMS, CCNE, ANLN and poor long-term prognosis in TNBC.
Conclusion. TNBC with AR expression is a heterogeneous subtype. It is associated with advanced age, metastatic involvement of regional lymph nodes, and expression of a large number of genes. According to our data, AR expression in TNBC is associated with unfavorable long-term prognosis of this category of patients.
A CONDUCTIVE NANOFIBER PVA/ZNO USING ELECTROSPINNING PROCESS AND ITS POTENTIALLY FOR EDIBLE ELECTRONIC
Authors: Rohman Yadi Mulyadi , Supriadi Dendin , Assegaf Sufiyah , Aliah Hasniah , Solehah Siska , Syifa Rahma
Published: February 2025

Electrospun nanofibers have been widely used for various applications. PVA/ZnO nanofiber composites have been successfully fabricated and their electrical properties have been tested. The purpose of this research is to investigate the potential of these nanofiber composites as edible electronic materials based on their conductivity. In this experiment, we used commercially available Polyvinyl Alcohol (PVA) and ZnO technical quality. The composites were prepared by mixing PVA and ZnO at weight per volume (w/v) concentrations. Nanofiber fabrication was carried out using the electrospinning technique with high voltage at 14 kV, a flow rate of 2 mL/hour, and humidity around 50%. The PVA/ZnO nanofibers were characterized using a digital microscope, Scanning Electron Microscope to observe surface morphology and diameter of nanofiber, and conductivity measurements were conducted to assess electrical conductivity. The results showed that optimum nanofibers were formed with a 10% concentration and varying ZnO have an average diameter size of 225 ± 0.5 nm. The addition of ZnO to PVA nanofibers enhances their electrical characteristics. The electrical conductivity of PVA/ZnO nanofibers increases with the addition of ZnO. The highest AC conductivity of PVA/ZnO nanofibers is 315 μS.m-2 at a concentration of 5 mg (w/v). This indicates that PVA/ZnO has good enough conductivity to be used in electronic devices. The PVA/ZnO nanofiber has a small diameter due to its viscosity, surface tension, and good molecular weight, making it capable of being drawn by electrospinning. ZnO is chosen for its ready availability and good conductivity properties. Therefore, the combination of these two materials enhances the conductivity characteristics of the nanofibers.
Sexual health literacy and sexual health behaviours among young adults in Ireland
Authors: Nolan Anne , Smyth Emer
Published: February 2025

Adolescence and young adulthood are critical periods in the development of healthy sexual health and relationships, as patterns of behaviour that develop during these life stages shape outcomes throughout the life course. Recent rises in notifications of certain sexually transmitted infections (STIs) among young people in Ireland have raised concerns over the extent to which young people have the skills and information to make healthy choices in relation to their sexual health and wellbeing. In this context, sexual health literacy – i.e., the degree to which individuals have the ability to find, understand and use information and services to inform decisions and actions – is a key protective factor for the prevention of negative sexual health outcomes and for allowing young people to be more in control of their own sexual and reproductive health. In this report, we used data from Cohort ’98 of Growing Up in Ireland, the national longitudinal study of children and young people in Ireland, to examine the factors associated with sexual health literacy among young adults, and how sexual health literacy is associated with sexual health behaviours (i.e., condom and contraception use). The Growing Up in Ireland data on sexual health literacy were collected in 2018 when the young people were 20 years of age, and the measure of sexual health literacy was based on answers to two questions that gauged knowledge of female fertility and STI prevention methods.
Boomerang Migration: Which Regions Have the Most, and Can It Make a Difference?
Authors: Whitaker Stephan D. , Huettner Brett D.
Published: February 2025

This District Data Brief analyzes how well regions in the Fourth District and across the United States draw back native residents who previously moved away. It also examines the extent to which these "boomerang migrants" contribute to the total populations of their respective regions.
Política de formação de professores bilíngues na fronteira do Brasil com o Paraguai
Authors: Bueno Mara Lucinéia Marques Correa , Souza Kellcia Rezende , Lima Meire Helen Dos Santos
Published: February 2025

O artigo teve o propósito de investigar a formação de professores bilíngues na região da fronteira Brasil e Paraguai a partir do Programa Escolas Interculturais de Fronteira (PEIF). O trabalho se sustentou pela abordagem qualitativa com o desenvolvimento de uma pesquisa em campo, no qual recorreu-se como instrumento de coleta de dados a entrevista semi-estruturada com uma gestora de instituição pública escolar localizada no Brasil, especificamente, no município de Ponta Porã-MS, que faz fronteira com o município paraguaio de Pedro Juan Caballero. Os resultados apontaram que o PEIF, mesmo assegurando a formação teórico-prática aos docentes da escola brasileira, foi prejudicado diante da descontinuidade das suas ações, o que inviabilizou a realização das atividades intercambiais entre os professores dos dois países: Brasil e Paraguai.
Employment opportunites for people with intellectual disabilites
Authors:   Jan Dlugosz University in Czestochowa, Suchon Anna
Published: February 2025

Objective: The objective of this article is to organize the knowledge regarding disability and
to initiate a discussion on the necessary changes in societal perceptions of individuals with
intellectual disabilities, with the aim of preparing them for self-determination.
Approach: In the text, I refer to my own research conducted during my doctoral studies.
The research consisted of the following stages: preliminary studies: Assessing the level of skills,
primarily in the area of independence (research tools used: PAC - H.C. Gunzburg's Progress
Assessment Chart for evaluating social development in individuals with intellectual disabilities,
HKI - Heidelberger Kompetenz-Inventar for individuals with intellectual disabilities); analysis
of the causes of observed differences (research tool: questionnaire); pedagogical experiment
lasting 4 years: Conducted with an experimental group and a control group. Both groups were
assessed every 6 months (research tools used: PAC - H.C. Gunzburg's Progress Assessment
Chart for evaluating social development in individuals with intellectual disabilities,
HKI - Heidelberger Kompetenz-Inventar for individuals with intellectual disabilities).
Follow-up study conducted 6 years after the experiment (research tools used: PAC - H.C.
Gunzburg's Progress Assessment Chart for evaluating social development in individuals with
intellectual disabilities, HKI - Heidelberger Kompetenz-Inventar for individuals with
intellectual disabilities.
Findings: I would like to demonstrate that by providing students with appropriate and,
importantly, practical opportunities to learn certain skills, they are capable of learning much
more.
Practical implications: As changes in a developing society occur more and more rapidly, it is
necessary to constantly update the methods of working and educating people with disabilities
to prepare them to function independently.
Originality/value: The concept of an individual with an intellectual disability deviates from
commonly applied standards. Many people perceive such individuals only as recipients of help
and support. However, it is essential to remember that they are also members of the community,
with associated duties, mandates, and prohibitions.
Keywords: intellectual disabilities, employment, society.
Category of the paper: Viewpoint, general review.
Creator and viewer activity on YouTube in Polish content about electric vehicles
Authors:   Institute of Economy and Informatics, Faculty of Organization and Management of Silesian University of Technology, Wyskwarski Marcin
Published: February 2025

Purpose: This study aims to examine the activity of content creators and viewers on YouTube
in the context of Polish-language videos related to electric vehicles (EVs). The study aims to
explore trends in video publication, user engagement through comments, and the relationships
between video characteristics (such as duration and views) and user interaction.
Design/methodology/approach: The research uses a dataset of 1152 videos and 125,680
comments collected from YouTube using Python and R tools. The videos were identified
through specific search phrases related to EVs. The methodology includes descriptive analysis
of video publication trends and linear regression models to investigate the relationships between
video duration, views, and comment count. Data were cleaned and pre-processed to remove
non-Polish comments, duplicate entries, and outliers.
Findings: The analysis revealed a growing trend in user engagement with EV-related content
on YouTube over the years. A small group of highly active users contributed the majority of
videos, while a significant portion of user interaction consisted of replies, indicating a high level
of viewer-to-viewer engagement. Regression models showed a statistically significant but weak
correlation between video duration and comments, as well as between video views and
comments, but found no significant relationship between video length and views.
Research limitations/implications: This study is limited to videos and comments in the Polish
language, which restricts the generalizability of the findings to other linguistic or cultural
contexts. Furthermore, data were collected up until May 2024, making the analysis of trends in
that year incomplete. Future research could include a broader range of content and explore
additional factors that influence user engagement, such as video content quality or audience
demographics.
Practical implications: The findings suggest that content creators in the EV sector on YouTube
may benefit from building more engaging discussions among viewers. Understanding that
longer videos or videos with more views may attract slightly more comments can help creators
tailor their content strategies. For platform managers and marketers, fostering user interaction
through replies and discussions may be a key way to increase engagement with content.
Originality/value: This study is among the first to analyse the dynamics of creator and viewer
activity on YouTube specifically within the Polish-language content about electric vehicles.
It contributes to a better understanding of how creators and viewers engage with this topic,
providing insights into content trends and user interaction that may guide future content
development strategies.
Keywords: YouTube, Electric vehicles, User engagement, Viewer comments, Creator activity,
Regression analysis.
Category of the paper: research paper.
Uncovering topics in YouTube comments on electric vehicles using Latent Dirichlet Allocation
Authors:   Institute of Economy and Informatics, Faculty of Organization and Management, Silesian University of Technology, Wyskwarski Marcin
Published: February 2025

Purpose: The purpose of this study is to analyse YouTube comments related to electric vehicles
(EVs) to uncover the underlying topics discussed by users. By applying Latent Dirichlet
Allocation (LDA), the study aims to gain a deeper understanding of public opinion and the key
themes driving conversations about EVs online.
Design/methodology/approach: This research utilized the “scrapetube” package to gather
YouTube video links related to EVs. Comments were then downloaded using the “youtube-
comment-downloader” package. After preprocessing the comments, including removing
duplicates and irrelevant content, Latent Dirichlet Allocation (LDA) was applied to identify
and analyze the topics discussed in these comments. The analysis focused on comments in
Polish to ensure contextual accuracy and relevance.
Findings: The study identified a diverse range of topics, including technical aspects, consumer
concerns, environmental impacts, market dynamics, and charging infrastructure. These topics
provide insights into the public's perception towards EVs.
Research limitations/implications: The analysis was confined to comments in Polish,
which may not capture the full spectrum of global perspectives. Future research could expand
the scope to include comments in other languages and from different platforms to provide
a more holistic view. Additionally, while LDA effectively identified key topics, some nuances
may be lost in the process of topic modeling. Further qualitative analysis could complement the
findings.
Practical implications: The insights gained from this study can help shape policies that address
consumer concerns about EV affordability and infrastructure. Manufacturers can focus on areas
that need improvement, such as enhancing battery capacity and increasing the efficiency and
range of EVs. Marketing strategies can be refined to highlight the benefits of EVs in everyday
use.
Originality/value: This study demonstrates the utility of LDA in uncovering the underlying
topics in YouTube comments about electric vehicles. It provides a comprehensive overview of
consumer interests and concerns, highlighting areas that require attention from policymakers,
manufacturers, and researchers. The methodology used in this study can serve as a blueprint for
further research into public opinion on other emerging technologies.
Keywords: Electric Vehicles (EVs), Latent Dirichlet Allocation (LDA), Topic Modeling,
YouTube Comments.
Category of the paper: research paper.
INVERTERS AND MULTILEVEL INVERTERS FOR POWER ELECTRONICS SYSTEMS
Authors: Kashappa Neelashetty
Published: February 2025

Multilevel inverters (MLIs) have emerged as a crucial technology in power electronics, offering enhanced performance in high-power and medium-voltage applications. Unlike conventional two-level inverters, MLIs generate stepped voltage waveforms that improve power quality, reduce harmonic distortion, and minimize voltage stress on power semiconductor devices. This paper explores the various topologies of multilevel inverters, including diode-clamped, flying capacitor, and cascaded H-bridge configurations, along with their working principles and applications. Special emphasis is placed on the advantages of MLIs in renewable energy systems, electric vehicles, and industrial motor drives. Furthermore, recent advancements in modulation techniques and control strategies, such as space vector modulation and model predictive control, are discussed to highlight their role in improving the efficiency and reliability of multilevel inverters. The study concludes by addressing the challenges associated with MLIs, including complexity, cost, and switching losses, while also presenting potential future research directions in this evolving field.
Information Behaviors of Marine Engineers at Sea and on Shore
Authors: Janssen Amber D
Published: February 2025

The information behaviors of professionals in their workplaces, including those related to various fields of engineering, have been widely studied. However, the information behaviors of marine engineers have not been examined. This study used a qualitative approach to collect data by conducting 13 in-depth interviews with marine engineers living in the United States. Inductive thematic analysis was used to identify the information needs, information types and formats used, the methods for verifying information, and the information communication practices used by marine engineers. The study found that many information behaviors of marine engineers align with other research on engineers. However, the results demonstrate that the working conditions at sea and in the maritime industry also create unique challenges, such as needing information for emergency or unexpected situations, a lack of access to information due to crew turnover, and lack of digitized or current versions of information. These results indicate that further research should investigate ways that the maritime industry can improve access to information and better prepare students for information use in this industry.
O Homoerotismo na Literatura Infantil: análises e reflexões sobre as histórias não contadas na hora do conto
Authors: Duran Francisco
Published: February 2025

Esta pesquisa descreve e problematiza a existência de Literatura Infantil com tema homoerótico para crianças de zero a cinco anos de idade em obras publicadas no Brasil. Adquiriu-se um total de 42 publicações nacionais e estrangeiras cujo tema era o homoerotismo. Para a realização desta pesquisa utiliza-se os conceitos de diferença numa abordagem pós-estruturalista na intenção de fazer aproximações com o pensamento de Michel Foucault e outros autores. Também, se busca nos Estudos Culturais respaldo para compreender a pluralidade sexual que hoje se vivencia, bem como seus enfrentamentos sociais, morais, religiosos, políticos e culturais. Trata-se de uma pesquisa bibliográfica de caráter qualitativo amparada no método da Análise de Conteúdo.
Palavras-chave: Literatura Infantil, Homoerotismo, Educação.