bluuebunny/crossref_metadata_2025 huggingface dataset:
MORTALITY OF ACUTE MYOCARDIAL INFARCTION IN RELATION WITH TIMI RISK SCORE
Authors:   Dr NB Cardiology, SSH, GMC Jammu., Ahmed Wani Owais , Ali Nasir ,   Consultant Cardiology, SSH, GMC Jammu., Qayoom Ouber ,   Dr NB Cardiology, SSH, GMC Jammu., Beniwal Rajveer ,   Dr NB Cardiology, SSH, GMC Jammu.
Published: January 2022

Background: The Thrombolysis in Myocardial Infarction (TIMI) risk score is said to be an important factor in predicting mortality risk in fibrinolysis-eligible STEMI patients. An attempt was made to assess the situation by comparing risk stratification based on the TIMI score with the hospital outcome of such individuals. Methods: 145 STEMI patients were included in this srudy , TIMI risk scores were calculated and analysed vis-Ã -vis various relevant parameters.. Based on their TIMI scores, the patients were placed into three risk groups: low-risk,moderate-risk, and high-risk. All patients received standard anti-ischemic medication, were thrombolyzed, monitored in the ICCU, and monitored throughout their hospital stay for post-MI sequelae. Results: According to the TIMI risk score, 79 patients (54.5%) had low-risk , 48 (33.1%) to the moderate-risk , and 18 (12.4%) to the high-risk . The highest mortality rate (total 17 deaths) was found in the high-risk group (55.6%), followed by moderate-risk (12.2%) and low-risk (1.28%) groups, respectively. Killips categorization grade 2-4 had the highest relative risk (RR-15.85) of the seven potentially dubious variables evaluated, followed by systolic BP 100mmHg (RR-10.48), diabetes mellitus (RR-2.79), and age >65 years (RR- 2.59). Conclusions: In patients with STEMI, the TIMI risk scoring system appears to be a straightforward, valid, and practical bedside tool for quantitative risk classification and short-term prognosis prediction.
ABHRAK BHASMA AND SIO2 INFLUENCED MOBILITY OF LIPIDS IN LIVER AND KIDNEY OF CCL4 INDUCED ACUTELY INTOXICATED ALBINO RAT
Authors:   Assistant Professor, Department of Zoology, P. D. V. P. Mahavidyalaya, Tasgaon, Dist-Sangli, (MS), India, Affiliated to Shivaji University, Kolhapur., Teli Parashuram , Kanase Aruna ,   National Toxicology Centre, APT Research Foundation, Sinhagad Road, Vadgaon Khurd, Pune-411 041.
Published: January 2022

In our earlier studies on CCl4 induced acute toxicity model (CCl4 3ml/kg body wt). Abhrak bhasma protects fatty degeneration of liver and associated nephrotoxicity in male albino rats. It had shown to function through production and management of free radicals (Teli and Kanase, 2020a, b). To study further the paths of Abhrak Bhasma mediated protection of acute hepatotoxicity and associated nephrotoxicity, liver, kidney and serum lipid contents were studied in present work. It shows no lipid accumulation in liver or kidney of normal rats by Abhrak Bhasma (10, 20, 30 and 40mg doses). But a same dose of silica in pure form (SiO2) is hepato and nephrotoxic in high doses in normal male albino rat. In acutely intoxicated rat also all the doses of Abhrak Bhasma influenced lipid contents of liver, kidney and serum show the protection of liver from fatty degeneration and also associated nephrotoxicity. Doses 30 and 40mg normalized the contents from liver, kidney and serum. The results are discussed to reveals the probable mode of action of Abhrak Bhasma.
Initial hypotensive therapy of primary glaucoma with the domestic latanoprost generic: efficacy and safety
Authors: Petrov S. Yu. , Kalinina O. M. , Yakubova L. V. , Kosakyan S. M. , Vasilenkova L. V. , Filippova O. M. , Zhuravleva A. N.
Published: January 2022

Purpose: a comparative study of the efficacy and safety of the Latanoprost-Optic drug and the original latanoprost drug administered to previously untreated patients with primary open-angle glaucoma (POAG). Material and methods. A double-blind, randomized, parallel-group study involved 60 patients (70 eyes) with newly diagnosed POAG, who were randomly divided into 2 groups of equal size. The patients of the main group (34 eyes) received Latanoprost-Optic, whilst the control group received the original preparation of latanoprost, 1 instillation in the evening. The reference points were the values of intraocular pressure, visual acuity, perimetric indices (standard deviation, standard deviation pattern), the average thickness of the retinal nerve fiber layer, the minimum width of the neuroretinal girdle, the thickness of the retinal nerve fiber layer in the macula, the thickness of the ganglion cell layer in the macula, the thickness of the inner plexiform layer, and the safety (adverse events). The observation period was 12 weeks. Results. After 2 weeks, both groups showed a statistically significant decrease in intraocular pressure, which remained stable after 6 and 12 weeks. The average decrease in intraocular pressure of those receiving Latanoprost-Optic was 30% and at no control point a statistically significant difference from the original drug was revealed. A positive dynamic of visual acuity, static perimetry indices and optical coherence tomography was registered, showing n significant intergroup differences. This may indicate that the drugs have an indirect neuroprotective effect. The adverse events included discomfort and redness of the bulbar conjunctiva, which were recorded in 7 out of 30 patients in the study group and in 6 out of 30 patients in the control group. All of them were mild and completely reversible. No serious or systemic adverse events were reported. Conclusion. Latanoprost-Optic has an efficacy comparable to that of the original latanoprost drug and has a comparable favorable safety profile.
SER PROFESSOR NA PERSPECTIVA INCLUSIVA: SABERES, FAZERES E COMPROMISSOS EM UMA TRÍADE FORMATIVA
Authors: Paz Cláudia Terra do Nascimento , Wisch Tasia Fernanda
Published: January 2022

Este estudo reflexivo foi construído com o intuito de problematizar a docência no contexto da educação brasileira, tratando especificamente de professores que atuam na sala de aula regular e que se encontram preocupados em qualificar suas práticas e que, ao mesmo tempo, estão buscando possibilidades para a concretização de uma educação verdadeiramente inclusiva. Para tanto, propomos a refletir sobre os saberes, os fazeres e os compromissos dos professores que atuam na perspectiva inclusiva, trazendo à tona a importância da formação docente para a discussão. Fundamentadas pelos estudos de Tardif (2002), López (2016) e Arroyo (2013, 2014) nossas reflexões estão assentadas no conceito de professor inclusivo, o qual é por nós entendido como aquele professional de que assume como protagonista de sua ação docente e dos processos de aprendizagem de todos seus estudantes.  Nessa direção, estruturamos nossas reflexões a partir de uma proposição de uma tríade formativa, a qual pressupõe a relação entre saberes, fazeres e compromissos, interligados, compondo a construção permanente do profissional inclusivo. Defende-se que cada elemento da tríade possui uma interdependência dos demais, da mesma forma que todos eles dependem da formação permanente e da experiência de cada professor, sendo esses processos individuais e coletivos ao mesmo tempo.
PERFILES DEL LECTOR UNIVERSITARIO: GUSTO, IMPORTANCIA Y VIVENCIA DE LA LITERATURA
Authors: Torres Adame Fabiola
Published: January 2022

En lo que respecta a la práctica de la lectura, es importante enfocarse no sólo en cuánto se lee, sino en qué se lee y para qué. Si los textos leídos inciden en el proceso de humanización del hombre. La obra literaria es fuente potencial de formación integral, pues da cuenta de la cultura y la condición humana. En el contexto universitario y a fin de implementar exitosamente actividades promotoras de la lectura, es clave conocer el perfil lector literario de los estudiantes, esto es: qué tanto les gusta y leen literatura, qué importancia conceden a la lectura de obras literarias, con qué frecuencia la hacen vida y en qué medida les gustaría participar en determinadas actividades promotoras de la lectura de obras literarias, si se ofrecieran en su universidad. Con este objetivo, se realizó un estudio cuantitativo con una muestra de 1,111 estudiantes de primer semestre en una Universidad Privada en México, a través del diseño y aplicación de una encuesta tipo Likert. El análisis de conglomerados jerárquicos arroja como resultado tres niveles de perfil lector literario: bajo, medio y alto, de acuerdo a la disposición de los estudiantes ante la literatura. En general, se concluye que es importante enfatizar la enseñanza sobre el poder transformador de la literatura y que las experiencias de lectura inviten a la vivencia del texto.
THE CAPITAL OF THE OTTOMAN EMPIRE IN EUROPE: BELGRADE ON THE FRONTIER (SERHAD) CITY (1521-1789)
Authors: ÖZKAN Selim Hilmi
Published: January 2022

Belgrade remained under the rule of many states, including Rome, Serbia, Hungary, and Bulgaria, until the Ottoman period. Since the city had long been an important crossroads, it was invaded many times. The fact that it was on the route to connect the Middle and West Europe with Asia Minor also played a key role in the invasion of Belgrade. Along with being on the way of important roads, Belgrade serves as a door for Europe. Known as the key to Europe, Belgrade could be conquered in 1521 by the Ottoman Empire although it was besieged many times. In the following years, Belgrade became one of the most strategic cities of the Ottoman Empire in the Balkans. Further, the city in the position of Captaincy of Danube remained significant in terms of its military, strategical and economical aspects until it was out of the Ottoman Empire’s hands.

This study is concerned with the importance of the city to the Ottoman Empire coupled with its economic and military importance, primarily using Ottoman archival documents. Although considerable research has been devoted to this topic, rather less attention has been paid to the political importance of the Belgrade City to the Ottoman Empire in the Europe. To this end, the current study specifically attempts to examine this issue.
İKİNCİ MEŞRUTİYET DÖNEMİ AYDINLARINDAN M. ZEKERİYA (SERTEL)’İN KADIN MESELESİ ÜZERİNE GÖRÜŞLERİ
Authors: KARA Serdar , UYANIK Necmi
Published: January 2022

23 Temmuz 1908’de İkinci Meşrutiyet’in ilan edilmesiyle birlikte İkinci Kuşak Jön Türk Hareketi uzun zamandır hedefledikleri siyasi inkılabı tamamladıklarına inanmışlardı. Sıra daha çetrefilli bir değişim dönüşüm sürecini içeren “İçtimai İnkılaba” gelmişti. İttihat ve Terakki Cemiyetinin güçlü olduğu Selanik’te oluşan “Yeni Hayat” çevresi bu toplumsal devrimi gerçekleştirmek üzere çıkardıkları yayınlarda çeşitli konuları işlemeye başlamışlardı. Bunlardan birisi sosyal inkılabın önemli bir parçası olarak gördükleri kadın meselesiydi. Selanik’teki Yeni Hayat çevresi içerisinde yer alan ve yazılarıyla içtimai inkılaba yön vermeye çalışan isimlerden birisi de M. Zekeriya idi. Sonraki yıllarda M. Zekeriya Sertel olarak Türk basın tarihinin önemli isimlerinden birisi haline gelecek olan M. Zekeriya, Yeni Felsefe Mecmuası, Hayat ve Şebab adlı çalışmalarında kadın meselesine değinmiştir. M. Zekeriya, dönemin Türk düşünce dünyasına büyük etkileri olan Fransız sosyolog Emile Durkheim’ın etkisiyle bu meseleye organizmacı bir bakış açısıyla yaklaşmıştır. Kadın meselesini kendi başına bir problem olarak sınırlandırmamış, bu meselenin doğrudan milletin geleceğiyle ilgili olduğunu önemle vurgulamıştır.
Effect-based water quality assessment of rivers receiving discharges from legacy mines by using acute and chronic bioassays with two cladoceran species
Authors: Mano H. , Iwasaki Y. , Shinohara N.
Published: January 2022

Information about the ecotoxicological impacts of surface waters that receive discharges from legacy mines is valuable to infer the ecological impacts on natural environment for managing mine discharges. In this study, we investigated behavioural and reproductive responses of two cladoceran species Ceriodaphnia dubia and Daphnia magna to water samples collected from metal-contaminated and reference rivers near legacy mines in Japan. The toxicity identification evaluation (TIE) of water samples that caused D. magna immobility was conducted to evaluate the key metals causing acute toxicity. The results of our water quality assessment performed using two cladoceran species demonstrated modest to significant adverse effects on their behaviour and reproduction, suggesting the potential for ecotoxicological impacts on natural populations and communities at several contaminated sites that received mine drainage. The results of TIE of water samples that caused D. magna immobility indicated likely contributions of Zn and Cu. These results imply that effect-based water quality assessments such as ours can provide direct and unique evidence of the ecotoxicological impacts of metals in river waters, which will be useful for better understanding and predicting the ecological effects of these metals in the natural environment.
Business households in the context of Vietnam's culture and law
Authors: Giang Vien The , Huong Vo Thi My
Published: January 2022

The article analyzes and clarifies the position and role of business households in the system of business entities in the market economy in Vietnam. From its small-scale position, restrictions on the rights to use labor, and business locations, current Vietnamese laws have established provisions to ensure equality in legal status, autonomy, and self-responsibility on business transactions of business households. However, the business household is built and managed based on the family, the members of the business household both show blood relation and economic relation. Therefore, the family traditional cultural factors have a huge impact on the internal and business relations of household businesses. The traditional family relationship and the relationship among the members (of the business household) in the business relations related to asset liability and the development support policy of the State will form the pillar to promote the development of household businesses to become an important and indispensable part of the market economy and international integration in our country currently.
Digital era 4.0
Authors: Rahmatullah Azam Syukur , Mulyasa E. , Syahrani Syahrani , Pongpalilu Fien , Putri Riana Eka
Published: January 2022

This study aims to explain the challenges of teachers in the digital era 4.0 and readiness to face these challenges. Through literature review. The author explains that there are several ways to face challenges education in the era of the industrial revolution 4.0 through capacity building and teacher skills by playing an active role in school. In addition, this research is to see the role of digital in education and student psychology. This research is a descriptive qualitative research. Data was collected by means of observation, interviews, and giving a questionnaire. The analysis technique uses interpretive analysis of the results of activities based on instruments. The results showed that the digital era 4.0 considered important for teachers to master in the 21st century, including the ability of teachers to use digital-based learning media. While the teacher develops psychology, namely the ability to creativity, critical thinking, collaboration, communication, innovation, problem solving, ICT skills, and character.
relevance of the message of the Qur'an to the goals of national education
Authors: Basir Abd. , Yahya M. Daud , Mubarak Hafiz , Akhyar Sayed , Nirwana AN Andri
Published: January 2022

Indonesia has a Muslim majority population and has two sources of education that both improve the quality of its citizens' educational resources. The author believes that the two sources, namely the Koran and the national education law, have strong relevance. To prove this assumption, we have conducted a series of studies of educational literature on many literature data published in various educational journals, both national and international. We found the data source through an electronic search on many journals, books, and websites that actively discuss religious and national education issues. After the collection of literature, we further examined the data evaluation system involved in the coding of conclusions drawn after high interpretation to obtain data that answered questions validly and reliably. Based on the data and discussion, we find a high relevance between the messages in the Koran and the goals of national education in Indonesia. It is hoped that this finding will become an essential input for improving educational science that links religious messages and national education.
Otonomi Kolektif dan Operasionalisasi Kesadaran Publik dalam Gerakan Solidaritas Pangan Jogja (SPJ)
Authors: Haryadi Didid
Published: January 2022

The Covid-19 pandemic has changed the pattern of interaction and socialization of community members. One of them is an effort to build awareness and social solidarity to help each other, especially in the dimension of domestic needs, such as food fulfillment. The Jogja Food Solidarity Movement (Solidaritas Pangan Jogja/SPJ) represents a collective action that grew because of the awareness of individuals and groups to distribute food aid to informal workers and marginalized groups in Yogyakarta. This paper examines two main points; first, how SPJ manages its social network pattern during the Covid-19 pandemic. Second, why the SPJ movement is autonomous. Using a qualitative approach and case study method, this paper finds that the SPJ movement maximizes social capital through networks and social support from non-governmental institutions, activist groups, artists, students, and the Kulon Progo Coastal Farmers Association (Paguyuban Petani Lahan Pantai/PPLP) to distribute food. to the public. The SPJ movement is formed organically, autonomously and rationally, which is a manifestation of systematically organized collective action. Through the analysis of the Resource Mobilization Theory (Teori Mobilisasi Sumber Daya/TMSD), the SPJ movement is needed to create and show collective dissatisfaction, especially during the Covid-19 pandemic, namely without which dissatisfaction is only at the individual level.
Desempenho escolar e diferentes papéis de participação no bullying: Um estudo transcultural
Authors: Zequinão Marcela Almeida , Medeiros Pâmella de , Silva Jorge Luiz da , Oliveira Lopes Luís , Pereira Beatriz Oliveira
Published: January 2022

O objetivo deste estudo é comparar o desempenho escolar entre os diferentes papéis de participação no bullying em dois países (Brasil e Portugal). Consiste num estudo transcultural de corte transversal de cunho exploratório e amostragem intencional. 376 crianças e adolescentes (do 5º e 6º ano de escolas públicas e privadas) participaram deste estudo, sendo 197 de Portugal e 179 do Brasil. Os papéis de participação no bullying foram obtidos mediante a aplicação de uma escala sociométrica e o desempenho escolar foi avaliado pelas médias finais obtidas ao final do ano letivo de quatro disciplinas (ciências, inglês, matemática e português). Os dados foram analisados através da estatística descritiva e inferencial (teste Kruskal-Wallis e U de Mann-Whitney). Destaca-se que em Portugal as vítimas apresentaram melhor desempenho escolar. Já no Brasil não foram encontradas diferenças significativas. Os dados apontam que o desempenho escolar parece ser uma variável mais importante no estabelecimento dos papéis de participação no bullying em Portugal do que no Brasil, indicando que a relação entre essas variáveis não pode ser considerada característica padrão entre os envolvidos neste fenómeno em diferentes países.
Revisi taksonomi Bloom: Kognitif, afektif, dan psikomotorik
Authors: Nafiati Dewi Amaliah
Published: January 2022

Revisi taksonomi Bloom menitikberatkan pada (1) perubahan aplikasi yang terdiri dari tiga bidang yaitu aplikasi bidang penyusunan kurikulum, aplikasi bidang instruksi pengajaran, aplikasi bidang assesment/ penilaian; dan (2) perubahan terminologi yang menekankan pada sub kategori sehingga penilaian menjadi lebih spesifik, mudah dalam menyusun penilaian pada kurikulum, serta mudah dalam menyusun instruksi pengajaran. Revisi taksonomi Bloom juga mengubah kata kunci operasional dari kata benda menjadi kata kerja dari level terendah sampai dengan level tertinggi.Terdapat perubahan yang sangat signifikan pada revisi taksonomi Bloom di domain kognitif yang terdiri dari dua dimensi yaitu dimensi pengetahuan dan dimensi proses kognitif. Dimensi pengetahuan berubah menjadi faktual, konseptual, prosedural, metakognisi. dimensi proses kognitif baru menjadi mengingat, memahami, mengaplikasikan, menganalisis, mengevaluasi, dan mencipta. Domain afektif meliputi rasa, nilai, apresiasi, antusiasme, motivasi, dan sikap tercermin pada perilaku/ attitude sehari-hari pada proses pembelajaran baik di dalam kelas maupun di luar kelas. Domain psikomotorik dirumuskan sebagai serangkaian kemampuan yang bersifat kongkrit dan abstrak. Bloom's taxonomic revision focuses on (1) application changes that consist of three fields, namely the application of curriculum development. application of teaching instruction area, application of assessment/ assessment field; and (2) changes in the terminology emphasizing sub-categories so that assessment becomes more specific, it is easy to arrange assessments in the curriculum, and easy to arrange instructions teaching. Revised Bloom's taxonomy also changed the operational keywords from words to verbs from the lowest level to the highest level. There is a very significant change in Bloom's revised taxonomy in the cognitive domain which consists of two dimensions, namely the dimension of knowledge and the dimension of cognitive processes. The dimension of knowledge changes into factual, conceptual, procedural metacognition. the dimension of the new cognitive process becomes remembering, understanding apply. analyze, evaluate and create. Affective domain includes taste, value, appreciation, enthusiasm, motivation. and attitudes are reflected in behavior everyday in the learning process both in the classroom and outside the classroom. Domain psychomotor formulated as a series of abilities that are concrete and abstract.
Analisis pelaksanaan mata kuliah pengenalan lapangan persekolahan (plp) secara daring berdasarkan experiential learning theory
Authors: Nugraheni Benedecta Indah
Published: January 2022

PLP merupakan mata kuliah praktik lapangan untuk memberi pengalaman langsung secara komprehensif kepada mahasiswa Fakultas Keguruan dan Ilmu Pendidikan (FKIP) mengenai dunia persekolahan dan untuk mengembangkan berbagai kompetensi yang dimiliki seorang guru profesional. Dengan adanya pandemi covid-19, PLP dilaksanakan secara daring, sehingga mahasiswa tidak dapat memperoleh pengalaman secara langsung di sekolah tempat pelaksanaan PLP. Praktik ini menjadi kurang ideal untuk mata kuliah PLP. Penelitian ini bertujuan menganalisis hasil refleksi pengalaman mahasiswa peserta PLP secara daring untuk mengetahui penguasaan capaian pembelajaran yang telah ditetapkan, pengalaman-pengalaman positif yang diperoleh dan kendala yang dihadapi mahasiswa, sikap atau nilai-nilai yang berkembang dalam diri mahasiswa, serta pengalaman inspiratif dan niat-niat yang dibangun untuk pengembangan diri yang muncul berdasarkan hasil refleksi. Penelitian ini merupakan penelitian kualitatif. Hasil penelitian menunjukkan bahwa mahasiswa dapat menguasai capaian pembelajaran dengan baik dan sangat baik, mahasiswa memperoleh berbagai pengalaman positif dan pengalaman mengatasi kendala yang muncul akibat pandemi, ada sikap atau nilai-nilai yang berkembang dalam diri mahasiswa, mahasiswa memperoleh pengalaman inspiratif, dan muncul niat-niat dari mahasiswa untuk pengembangan diri. Dengan demikian, siklus belajar dalam experiential learning theory dialami oleh mahasiswa peserta PLP daring.School Introduction (PLP) is a field practice course to provide comprehensive direct experience to students of the Teacher Training and Education Faculty (FKIP) regarding school understanding and to develop the various competencies of a professional teacher. In the covid-19 pandemic, PLP has been implemented online, so students cannot gain experience directly at the school where PLP is implemented. This practice is less than ideal for the PLP course. This research aimed to analyze the results of reflections on the experiences of students participating in online PLP to determine the mastery of predetermined learning outcomes, positive experiences, obstacles faced by students, attitudes or values that were developed by students, inspirational experiences, and intentions for self-development that arises based on the results of reflection. This research was a qualitative research. The results showed that students could master learning outcomes well and very well, gained various positive experiences and experiences overcoming obstacles that arise due to the pandemic, developed attitudes or values, gained inspirational experiences, and developed intentions for self-development. Thus, the learning cycle in experiential learning theory was experienced by the students participating the online PLP.
Improvement of Medical Treatment in Japanese Patients With Metastatic Renal Cell Carcinoma
Authors: FUJIWARA RYO , KOMAI YOSHINOBU , OGUCHI TOMOHIKO , NUMAO NOBORU , YAMAMOTO SHINYA , YONESE JUNJI , YUASA TAKESHI
Published: January 2022

Background/Aim: To evaluate the relationship between treatment period and overall survival (OS) and to identify clinical factors associated with OS in patients with metastatic renal cell carcinoma (mRCC). Patients and Methods: Two hundred thirteen consecutive patients with mRCC receiving systemic therapy between 2008 and 2020 were divided into two groups: those starting first-line therapy in 2008-2015 (n=133) and those in 2016-2020 (n=80). Clinical factors associated with OS were retrospectively and statistically analyzed. Results: Median OS and one-, three- and five-year OS rates were not reached and 88.7%, 64.9%, and 64.9% in patients treated in 2016-2020; 31.4 months and 78.5%, 42.8% and 34.2% in 2008-2015 (p=0.0013). Multivariate analysis identified the period in which first-line therapy was started as the strongest predictor for OS (p=0.0002). Conclusion: OS was significantly better in mRCC patients treated in 2016-2020 than in 2008-2015. Treatment period was the strongest predictor for OS.
Age-related Survival Outcomes for Pancreatic Cancer by Age
Authors: KASBI ALI ABBASZADEH , ASHARY MOHAMMED ALI , BAKSH MIZBA , NUSSBAUM SAMUEL , ATTWOOD KRISTOPHER , GABRIEL EMMANUEL
Published: January 2022

Background/Aim: Pancreatic cancer has a very poor prognosis, though outcomes based on age are not well characterized. The aim of current study was to analyze the survival of patients with pancreatic cancer based on age. Patients and Methods: Using National Cancer Data Base (NCDB), we determined survival outcome based on age among patients with pancreatic cancer. Results: A total of 423,482 patients between 2004 and 2017 were included in the study. Patients aged between 18 and 40-years-old had the worst 3-year survival rate among stage 1 disease. Conversely, patients over 65-years-old had the worst 3-year survival rate and presented with more advanced disease (clinical stages 3 and 4). Conclusion: Older patients with more advanced disease had worse survival.
Monostotic Fibrous Dysplasia in the Femur Strongly Expressing RANKL With Concomitant Osteoporotic Vertebral Compression Fracture: A Case Report
Authors: AZURIN EDELYN S. , YAMAMOTO NORIO , HAYASHI KATSUHIRO , TAKEUCHI AKIHIKO , MIWA SHINJI , IGARASHI KENTARO , HIGUCHI TAKASHI , YONEZAWA HIROTAKA , MORINAGA SEI , ASANO YOHEI , SAITO SHIRO , TSUCHIYA HIROYUKI
Published: January 2022

Background/Aim: This study aimed to present a rare case of fibrous dysplasia (FD) in a healthy young adult man with a concomitant osteoporotic vertebral compression fracture. FD is a benign lesion of the bone characterized by replacement of the medullary component with fibro-osseous tissue that contains abnormally arranged trabeculae of immature woven bone. Recently it has been reported that several bone tumors including FD express the receptor activator of nuclear factor-kappa B (RANK) and its ligand (RANKL). Therefore, we hypothesized that FD contributed to osteoporosis, linked by the RANK-RANKL pathway of osteoclastogenesis. Case Report: We report the case of a healthy man with monostotic femoral fibrous dysplasia (FD) with concomitant 7th thoracic vertebra compression fracture due to osteoporosis [young adult mean (YAM) was 79% in bone mineral density (BMD)]. After curettage of the FD, artificial bone grafting in the cavity, and administration of alendronate sodium, BMD improved considerably within 9 months. FD is a benign bone condition in which abnormal fibrous tissue replaces normal bone. The axis of the receptor activator of nuclear factor-kappa B (RANK) and its ligand (RANKL) has been implicated in osteoporosis pathogenesis. RANKL immunohistochemical staining was performed, and strong staining of stromal cells was observed compared to other FD cases that showed weak to moderate staining. Conclusion: The presence of FD might have contributed to the low BMD due to the RANK-RANKL axis acting as osteoclastogenesis stimulator.
FOLFIRINOX as First-line Chemotherapy in Japanese Patients Suffering from Metastatic Pancreatic Cancer (KOBE FOLFIRINOX Study)
Authors: HATACHI YUKIMASA , MOHAN SHARAD R. , KOTAKE TAKESHI , SATAKE HIRONAGA , OKITA YOSHIHIRO , YASUI HISATERU , TSUJI AKIHITO
Published: January 2022

Background/Aim: FOLFIRINOX (oxaliplatin, irinotecan, 5-fluorouracil, and leucovorin) combination chemotherapy is the gold-standard therapy for advanced pancreatic cancer. In this study, FOLFIRINOX dosages for Japanese patients were established enabling FOLFIRINOX therapy optimization for efficient use. Patients and Methods: Patients with advanced pancreatic cancer were treated with varying doses of FOLFIRINOX to determine the optimum dosage for highest remission outcomes with the least post-chemotherapy toxicities. Results: Patients given 180 mg of irinotecan and a 400 mg bolus of 5-fluorouracil (5-FU) showed a marked difference in outcome when compared to irinotecan 180 mg given without the 5-FU bolus, with the overall response rate being 28%, a survival time of 6.4 months and progression-free survival time of 4.5 months. Conclusion: The optimum dose of FOLFIRINOX was a dosage combination of oxaliplatin 85 mg/m2, irinotecan 180 mg/m2, l-leucovorin 400 mg/m2 and 5-FU 2,400 mg/m2, administered as a continuous 46-h infusion.
Using Health Concept Surveying to Elicit Usable Evidence: Case Studies of a Novel Evaluation Methodology
Authors: Mariakakis Alex , Karkar Ravi , Patel Shwetak N , Kientz Julie A , Fogarty James , Munson Sean A
Published: January 2022

Background

Developers, designers, and researchers use rapid prototyping methods to project the adoption and acceptability of their health intervention technology (HIT) before the technology becomes mature enough to be deployed. Although these methods are useful for gathering feedback that advances the development of HITs, they rarely provide usable evidence that can contribute to our broader understanding of HITs.

Objective

In this research, we aim to develop and demonstrate a variation of vignette testing that supports developers and designers in evaluating early-stage HIT designs while generating usable evidence for the broader research community.

Methods

We proposed a method called health concept surveying for untangling the causal relationships that people develop around conceptual HITs. In health concept surveying, investigators gather reactions to design concepts through a scenario-based survey instrument. As the investigator manipulates characteristics related to their HIT, the survey instrument also measures proximal cognitive factors according to a health behavior change model to project how HIT design decisions may affect the adoption and acceptability of an HIT. Responses to the survey instrument were analyzed using path analysis to untangle the causal effects of these factors on the outcome variables.

Results

We demonstrated health concept surveying in 3 case studies of sensor-based health-screening apps. Our first study (N=54) showed that a wait time incentive could influence more people to go see a dermatologist after a positive test for skin cancer. Our second study (N=54), evaluating a similar application design, showed that although visual explanations of algorithmic decisions could increase participant trust in negative test results, the trust would not have been enough to affect people’s decision-making. Our third study (N=263) showed that people might prioritize test specificity or sensitivity depending on the nature of the medical condition.

Conclusions

Beyond the findings from our 3 case studies, our research uses the framing of the Health Belief Model to elicit and understand the intrinsic and extrinsic factors that may affect the adoption and acceptability of an HIT without having to build a working prototype. We have made our survey instrument publicly available so that others can leverage it for their own investigations.
Intensive Care Unit–Specific Virtual Reality for Critically Ill Patients With COVID-19: Multicenter Randomized Controlled Trial
Authors: Vlake Johan H , van Bommel Jasper , Wils Evert-Jan , Bienvenu Joe , Hellemons Merel E , Korevaar Tim IM , Schut Anna FC , Labout Joost AM , Schreuder Lois LH , van Bavel Marten P , Gommers Diederik , van Genderen Michel E
Published: January 2022

Background

Although psychological sequelae after intensive care unit (ICU) treatment are considered quite intrusive, robustly effective interventions to treat or prevent these long-term sequelae are lacking. Recently, it was demonstrated that ICU-specific virtual reality (ICU-VR) is a feasible and acceptable intervention with potential mental health benefits. However, its effect on mental health and ICU aftercare in COVID-19 ICU survivors is unknown.

Objective

This study aimed to explore the effects of ICU-VR on mental health and on patients’ perceived quality of, satisfaction with, and rating of ICU aftercare among COVID-19 ICU survivors.

Methods

This was a multicenter randomized controlled trial. Patients were randomized to either the ICU-VR (intervention) or the control group. All patients were invited to an COVID-19 post-ICU follow-up clinic 3 months after hospital discharge, during which patients in the intervention group received ICU-VR. One month and 3 months later (4 and 6 months after hospital discharge), mental health, quality of life, perceived quality, satisfaction with, and rating of ICU aftercare were scored using questionnaires.

Results

Eighty-nine patients (median age 58 years; 63 males, 70%) were included. The prevalence and severity of psychological distress were limited throughout follow-up, and no differences in psychological distress or quality of life were observed between the groups. ICU-VR improved satisfaction with (mean score 8.7, SD 1.6 vs 7.6, SD 1.6 [ICU-VR vs control]; t64=–2.82, P=.006) and overall rating of ICU aftercare (mean overall rating of aftercare 8.9, SD 0.9 vs 7.8, SD 1.7 [ICU-VR vs control]; t64=–3.25; P=.002) compared to controls. ICU-VR added to the quality of ICU aftercare according to 81% of the patients, and all patients would recommend ICU-VR to other ICU survivors.

Conclusions

ICU-VR is a feasible and acceptable innovative method to improve satisfaction with and rating of ICU aftercare and adds to its perceived quality. We observed a low prevalence of psychological distress after ICU treatment for COVID-19, and ICU-VR did not improve psychological recovery or quality of life. Future research is needed to confirm our results in other critical illness survivors to potentially facilitate ICU-VR’s widespread availability and application during follow-up.

Trial Registration

Netherlands Trial Register NL8835; https://www.trialregister.nl/trial/8835

International Registered Report Identifier (IRRID)

RR2-10.1186/s13063-021-05271-z
Loss of Weight Gained During the COVID-19 Pandemic: Content Analysis of YouTube Videos
Authors: Tang Hao , Kim Sungwoo , Laforet Priscila E , Tettey Naa-Solo , Basch Corey H
Published: January 2022

Background

Many people experienced unintended weight gain during the COVID-19 pandemic, which has been discussed widely on social media.

Objective

This study aims to describe the content of weight loss videos on YouTube (Google LLC) during the COVID-19 pandemic.

Methods

By using the keywords weight loss during quarantine, the 100 most viewed English-language videos were identified and coded for content related to losing weight gained during the COVID-19 pandemic.

Results

In total, 9 videos were excluded due to having non-English content or posting data before the COVID-19 pandemic. The 91 videos included in the study sample acquired 407,326 views at the time of study and were roughly 14 minutes long. A total of 48% (44/91) of the sample videos included graphic comparisons to illustrate weight change. Videos that included a graphic comparison were more likely to have content related to trigger warnings (χ21=6.05; P=.01), weight loss (χ21=13.39; P<.001), negative feelings during quarantine (χ21=4.75; P=.03), instructions for losing weight (χ21=9.17; P=.002), self-love (χ21=6.01; P=.01), body shaming (χ21=4.36; P=.04), and special dietary practices (χ21=11.10; P<.001) but were less likely to include food recipes (χ21=5.05; P=.03). Our regression analysis results suggested that mentioning quarantine (P=.05), fat-gaining food (P=.04), self-care and self-love (P=.05), and body shaming (P=.008) and having presenters from both sexes (P<.001) are significant predictors for a higher number of views. Our adjusted regression model suggested that videos with content about routine change have significantly lower view counts (P=.03) than those of videos without such content.

Conclusions

The findings of this study indicate the ways in which YouTube is being used to showcase COVID-19–related weight loss in a pre-post fashion. The use of graphic comparisons garnered a great deal of attention. Additional studies are needed to understand the role of graphic comparisons in social media posts. Further studies that focus on people’s attitudes and behaviors toward weight change during the COVID-19 pandemic and the implications of social media on these attitudes and behaviors are warranted.
Using Health Concept Surveying to Elicit Usable Evidence: Case Studies of a Novel Evaluation Methodology (Preprint)
Authors: Mariakakis Alex , Karkar Ravi , Patel Shwetak N , Kientz Julie A , Fogarty James , Munson Sean A
Published: January 2022

BACKGROUND

Developers, designers, and researchers use rapid prototyping methods to project the adoption and acceptability of their health intervention technology (HIT) before the technology becomes mature enough to be deployed. Although these methods are useful for gathering feedback that advances the development of HITs, they rarely provide usable evidence that can contribute to our broader understanding of HITs.

OBJECTIVE

In this research, we aim to develop and demonstrate a variation of vignette testing that supports developers and designers in evaluating early-stage HIT designs while generating usable evidence for the broader research community.

METHODS

We proposed a method called health concept surveying for untangling the causal relationships that people develop around conceptual HITs. In health concept surveying, investigators gather reactions to design concepts through a scenario-based survey instrument. As the investigator manipulates characteristics related to their HIT, the survey instrument also measures proximal cognitive factors according to a health behavior change model to project how HIT design decisions may affect the adoption and acceptability of an HIT. Responses to the survey instrument were analyzed using path analysis to untangle the causal effects of these factors on the outcome variables.

RESULTS

We demonstrated health concept surveying in 3 case studies of sensor-based health-screening apps. Our first study (N=54) showed that a wait time incentive could influence more people to go see a dermatologist after a positive test for skin cancer. Our second study (N=54), evaluating a similar application design, showed that although visual explanations of algorithmic decisions could increase participant trust in negative test results, the trust would not have been enough to affect people’s decision-making. Our third study (N=263) showed that people might prioritize test specificity or sensitivity depending on the nature of the medical condition.

CONCLUSIONS

Beyond the findings from our 3 case studies, our research uses the framing of the Health Belief Model to elicit and understand the intrinsic and extrinsic factors that may affect the adoption and acceptability of an HIT without having to build a working prototype. We have made our survey instrument publicly available so that others can leverage it for their own investigations.
Peer Review of “Telerehabilitation for People With Physical Disabilities and Movement Impairment: A Survey of United Kingdom Practitioners” (Preprint)
Authors:   Anonymous
Published: January 2022

UNSTRUCTURED

Peer review of ms#30516.
Peer Review of “Telerehabilitation for People With Physical Disabilities and Movement Impairment: A Survey of United Kingdom Practitioners” (Preprint)
Authors: Stein Maria Stella
Published: January 2022

UNSTRUCTURED

This is peer review of ms#30516.
The effects of virtual reality telemedicine a single pediatric use case patient with PTSD, post COVID-19: Exploratory research method. (Preprint)
Authors: Bogdanski Erin
Published: January 2022

UNSTRUCTURED

This paper is an exploratory research comparison between using standard tele psych over 2D devices with HMD ( Head Mounted Device) using the Thera VRTM software. The single case example is with the pediatric mental health subject, and was specifically used to treat PTSD and co morbid symptoms related to the impact of COVID-19. The case usage was all delivered as telemedicine, and was conducted in private practice. Interventions used on all devices were Trauma Focused CBT. Results suggested a positive improvement on both patient engagement and outcome in treatment after continuous use of Virtual Reality as telehealth with avatar technology. Written informed consent was obtained from the minor’s legal guardian under the THERA VR™ agreement, for the publication of any potentially identifiable images or data included in this article.
Recommendations for the Quality Management of Patient-Generated Health Data in Remote Patient Monitoring: Mixed Methods Study (Preprint)
Authors: Abdolkhani Robab , Gray Kathleen , Borda Ann , DeSouza Ruth
Published: January 2022

BACKGROUND

Patient-generated health data (PGHD) collected from innovative wearables are enabling health care to shift to outside clinical settings through remote patient monitoring (RPM) initiatives. However, PGHD are collected continuously under the patient’s responsibility in rapidly changing circumstances during the patient’s daily life. This poses risks to the quality of PGHD and, in turn, reduces their trustworthiness and fitness for use in clinical practice.

OBJECTIVE

Using a sociotechnical health informatics lens, we developed a data quality management (DQM) guideline for PGHD captured from wearable devices used in RPM with the objective of investigating how DQM principles can be applied to ensure that PGHD can reliably inform clinical decision-making in RPM.

METHODS

First, clinicians, health information specialists, and MedTech industry representatives with experience in RPM were interviewed to identify DQM challenges. Second, these stakeholder groups were joined by patient representatives in a workshop to co-design potential solutions to meet the expectations of all the stakeholders. Third, the findings, along with the literature and policy review results, were interpreted to construct a guideline. Finally, we validated the guideline through a Delphi survey of international health informatics and health information management experts.

RESULTS

The guideline constructed in this study comprised 19 recommendations across 7 aspects of DQM. It explicitly addressed the needs of patients and clinicians but implied that there must be collaboration among all stakeholders to meet these needs.

CONCLUSIONS

The increasing proliferation of PGHD from wearables in RPM requires a systematic approach to DQM so that these data can be reliably used in clinical care. The developed guideline is an important next step toward safe RPM.
The Computer Will See You Now: A Scoping Review of Digital Tools Designed to Obtain the History of Present Illness from Patients (Preprint)
Authors: Berdahl Carl Thomas , Henreid Andrew J , Pevnick Joshua M , Zheng Kai , Nuckols Teryl K
Published: January 2022

BACKGROUND

Many medical conditions—perhaps 80% of them—can be diagnosed by taking a thorough history of present illness (HPI). In the clinical setting, however, situational factors such as interruptions and time pressure may cause interactions with patients to be brief and/or fragmented. One solution for improving clinicians’ ability to collect a thorough HPI and maximize efficiency and quality of care could be to use a digital tool to obtain the HPI prior to face-to-face evaluation by a clinician.

OBJECTIVE

Our objective was to identify and characterize digital tools that have been designed to (1) obtain the history of present illness (HPI) directly from patients or caregivers and (2) present this information to clinicians before a face-to-face encounter. We also sought to describe outcomes reported in testing of these tools, especially those related to usability, efficiency, and quality of care.

METHODS

We conducted a scoping review using pre-defined search terms in the following databases: MEDLINE, CINAHL, PsychInfo, Web of Science, Embase, IEEE Digital Library, ACM Digital Library, and ProQuest Dissertations. Two reviewers screened titles and abstracts for relevance, performed full-text reviews of articles meeting inclusion criteria, and used a pile sorting procedure to identify distinguishing characteristics of the tools. Information describing the tools was primarily obtained from identified peer-reviewed sources; supplementary information was also obtained from tool websites and through direct communications with tool creators.

RESULTS

We identified 18 tools meeting inclusion criteria. Among them, 14 tools used primarily close-ended and/or multi-choice questions, 1 tool used free-text input, and 3 used conversational (chatbot) style. In total, 10 tools were tailored to specific patient subpopulations, and 8 did not specify a target subpopulation. Seven tools included multilingual support, and 12 had the capability to transfer data directly into the electronic health record. Studies of the tools reported on various outcome measures related to usability, efficiency, and/or quality of care.

CONCLUSIONS

The 18 HPI tools we identified varied greatly in their purpose and functionality. There was no consensus on how patient-generated information should be collected or presented to clinicians. Existing tools have undergone inconsistent levels of testing with a wide variety of different outcome measures used in evaluation, including some related to usability, efficiency, and quality of care. There is substantial interest in using digital tools to obtain the HPI from patients, but the outcomes measured have been inconsistent. Future research should focus on whether using HPI tools can lead to improved patient experience and health outcomes.

CLINICALTRIAL

N/A