bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-Time Bowel Perfusion Monitoring with FUJIFILM Eluxeo in Colorectal Surgery
Authors: Martucci Jordan , Williams Brian , Swinford Aubrey , Gupta Abhinav , Broccard Sacha , Cologne Kyle G. , Shin Joongho , Lee Sang W.
Published: February 2025

Background:
Anastomotic leak is a serious complication of bowel anastomosis, with a multifactorial etiology. Thorough intraoperative evaluation of the anastomosis using white light endoscopy and leak tests is critical. Indocyanine green fluorescence angiography (ICG-FA) has emerged as a tool to assess bowel perfusion but has limitations, including patient allergies and procedural complexity. The FUJIFILM Eluxeo Vision system uses the Oxygen Saturation Index (OSI) to measure tissue oxygenation saturation (StO2) in real time, without requiring dye injection. This provides a quantitative approach for assessing bowel perfusion.
Materials and Methods:
We used the FUJIFILM Eluxeo Vision system to obtain intraoperative mucosal StO2 measurements in 12 patients post colon resection and anastomosis. Measurements were taken at four locations: proximal base, proximal staple line, distal staple line, and distal base. Patients were followed longitudinally via chart review to monitor outcomes.
Results:
The average StO2 differences were + 12.6% between the proximal base and proximal staple line and + 15.4% between the distal base and distal staple line. Significant differences were observed between well-perfused mucosa and staple lines (proximal: P = 0.005; distal: P = 0.003). No patients developed an anastomotic leak during the study.
Conclusions and Future Directions:
The Eluxeo Vision system provides valuable, quantitative data on tissue perfusion at and near anastomotic sites, complementing traditional white light endoscopy and leak tests. Larger prospective studies with long-term follow-up are needed to confirm the relationship between StO2 measurements and clinical outcomes such as anastomotic leaks and surgical site infections.
Risk Prediction Model for Elderly Differentiated Thyroid Cancer Based on Combined Sleep Quality Assessment and Multimodal Ultrasound
Authors: Lou Xudan , Yi Na , Liu Yingchun , Xu Yuanyuan , Qiu Jieyuzhen , Tao Xiaoming , Bao Zhijun
Published: February 2025

Objective: To explore the differential diagnosis for benign and malignant thyroid nodules and the diagnostic value of sleep quality, to construct and validate a risk prediction model, providing the basis for clinical treatment decision for elderly thyroid cancer.
Methods: Clinical data, Pittsburgh Sleep Quality Index (PSQI), and multimodal ultrasound were collected from elderly patients undergoing fine needle aspiration biopsy or thyroid surgery in our department of endocrinology and general surgery. Postoperative pathological served as the gold standard, binary logistic regression identified significant risk factors, and the receiver-operating characteristic (ROC) curves was plotted to construct and validate the prediction model.
Results: Among 763 enrolled patients (566 benign and 197 malignant), multivariate analysis revealed independent risk factors: TPOAB positive, daytime dysfunction, PSQI > 7, irregular nodule shape, calcification, blood flow, high elasticity scores, and low contrast enhancement. The area under the curve (AUC) for the combined model was 0.860, significantly higher than models using multimodal ultrasound alone (AUC = 0.824) or multimodal ultrasound with TPOAB (AUC = 0.831), p < 0.05. The nomogram-based prediction model demonstrated excellent discrimination, calibration, and clinical utility in internal and external validation.
Conclusions: Integrating sleep quality assessment with multimodal ultrasound assisted in the differentiation of thyroid nodules in the elderly, thus may improve the preoperative diagnostic levels. Risk prediction model in a nomogram format provided an intuitive and reliable tool for clinical decision-making.
Strong nuclear expression of HOXB13 is a reliable surrogate marker for DNA methylome profiling to distinguish myxopapillary ependymoma from spinal ependymoma
Authors: Purkait Suvendu , Praeger Sophia , Felsberg Jörg , Pauck David , Kaulich Kerstin , Wolter Marietta , Koppstein David , Reifenberger Guido
Published: February 2025

Spinal ependymoma and myxopapillary ependymoma are the two most common spinal ependymal tumor types that feature distinct histological characteristics, genetic alterations and DNA methylation profiles. Their histological distinction may be difficult in individual cases and molecular diagnostic assessment, in particular DNA methylome profiling, may then be required to assign the correct diagnosis. Expression of the homeobox gene HOXB13 at the mRNA and protein levels has been reported as a frequent finding in myxopapillary ependymoma that may serve as a diagnostic marker for these tumors. Here, we evaluated the diagnostic role of HOXB13 immunostaining in 143 spinal neoplasms, comprising 54 histologically classified myxopapillary ependymomas, 46 histologically classified spinal ependymomas, and various other tumor types. Immunohistochemical results for HOXB13 protein were compared to molecular findings obtained by bead array-based DNA methylation and DNA copy number profiling, as well as next generation gene panel sequencing-based mutational analysis. Our findings indicate strong nuclear HOXB13 expression as a reliable diagnostic marker for molecularly confirmed myxopapillary ependymoma. Moreover, we provide evidence that differential HOXB13 protein expression is related to differential HOXB13-associated CpG site methylation in myxopapillary versus spinal ependymomas, which can be assessed by targeted DNA methylation analysis. Taken together, immunohistochemistry for HOXB13 protein expression and targeted DNA methylation analysis of HOXB13 represent useful surrogate approaches that may substitute for DNA methylome profiling in routine diagnostics and facilitate precise classification of spinal ependymal tumors. In particular, strong nuclear HOXB13 immunoreactivity may serve as a novel diagnostic criterion for the classification of myxopapillary ependymoma.
Biobased Tricomponent (carboxymethyl chitosan/ cerium dioxide/iron III oxide) nanocomposite flakes for multifarious environmental decontaminations: magnetically separable and antimicrobial photocatalyst
Authors: Elsherbiny Dalia A. , Omer Noha , Abdulaziz Fahad , Alanazi Abdulaziz
Published: February 2025

Carboxymethyl chitosan (CMCs) has been widely used in wastewater treatment due to its efficient functional groups. To boost its efficacy, a nanocomposite with two metal oxides, cerium dioxide (CeO2) and iron oxide (Fe2O3), was formed using the ball milling technique. Two concentrations (0.15 and 0.3g) of both metal oxides were loaded to CMCs and labeled as 0.15CeO2/Fe2O3/CMCs and 0.3CeO2/Fe2O3/CMCs nanocomposite and their photocatalytic performance was compared with the blank CMCs. Upon grinding, CMCs exhibited flake-like shapes that were significantly coated with CeO2 and Fe2O3. The nanocomposites were evaluated for their photocatalytic performance by measuring the degradation of Malachite Green (MG) dye under various conditions. The 0.15CeO2/Fe2O3/CMCs nanocomposite successfully achieved complete dye degradation at a concentration of 15 mg/L after 150 min, while the 0.3CeO2/Fe2O3/CMCs seized the degradation in 120 min. The research found that 400 ppm of catalyst was the ideal catalyst dose and that a pH 6 was optimum for photocatalytic degradation. The antibacterial activity was assessed against Gram-positive and negative bacteria and the 0.3CeO2/Fe2O3/CMCs exhibited notable antibacterial efficacy. The overall results reveal that CeO2/Fe2O3/CMCs nanocomposite flakes are efficient for the photocatalytic breakdown of organic dyes in wastewater emphasizing their potential for addressing environmental issues and combating microbial contamination.
Assessing Socio-Economic Disparities in Heat Stress Vulnerability and Adaptive Capacity: A Comparative Study of Higher-Class Residents and Slum Dwellers in Dhaka
Authors: Mosaddek Nafisa , Ahmed Ayrin
Published: February 2025

Heat stress is a serious health and economic threat to the residents of Dhaka, the capital of Bangladesh. The main causes of the increasing heat stress in Dhaka are climate change and rapid urbanization, which have resulted in a loss of green spaces and a rise in land surface temperature. The effects of heat stress are not evenly distributed among the population. The poor and vulnerable groups, such as slum dwellers, street vendors, factory workers, and women and children, are more exposed and less resilient to the extreme heat. Heat stress can cause dehydration, heat exhaustion, heat stroke, and even death. It can also reduce labor productivity, impair cognitive function, and exacerbate pre-existing health conditions. To address the heat stress challenge, Dhaka needs to adopt a comprehensive and coordinated approach that involves multiple stakeholders and sectors. Some of the possible solutions include increasing green spaces and urban forestry, improving building design and insulation, enhancing public awareness and education, providing cooling facilities and shelters, and developing heat action plans and early warning systems.
Post-Election Anxiety on Academic Performance Among Senior High School Teachers and Students in Ghana: A Case of Twifo Hemang Lower Denkyira District, Central Region
Authors: AMOAH-OPPONG DANIEL , BIO JODY YEBOAA , APPIAH MICHAEL
Published: February 2025

Elections serve as a fundamental element of democracy and frequently induce strong emotions and political tensions, which can greatly affect societal well-being like education. This research examines post-election anxiety among senior high school teachers and students, specifically in Twifo Hemang Lower Denkyira District in the Central Region of Ghana. It focuses on its psychological, social, and educational consequences. Although there is extensive global research regarding election-related anxiety, there has been limited focus on its impact on educational stakeholders in sub-Saharan Africa. This study addresses this gap by examining the experiences, coping strategies, and educational consequences of post-election anxiety in Ghana. This study employed a qualitative research design based on phenomenology. The study gathered insights from 10 teachers and 15 students through in-depth interviews and focus group discussions. These participants were carefully and purposefully selected to ensure a range of perspectives. Thematic analysis showed that post-election anxiety negatively affected the mental health of both teachers and students, which hampered teacher effectiveness and reduced student engagement and academic performance. Teachers reported feeling emotionally drained and less motivated, whereas students encountered increased anxiety and a diminished ability to concentrate on their studies. Coping strategies differed because teachers often found comfort in social interactions and political discourse, while students had difficulty managing their anxieties. The results highlight the pressing need to incorporate mental health and emotional resilience programs into educational policies because it will help lessen disruptions in the teaching and learning process to preserve academic outcomes. This research illustrates the link between political events and educational well-being, calling for proactive measures to foster a supportive learning environment. Policymakers and educational leaders need to prioritise mental health resources in schools to ensure resilience during election periods. Educational institutions can sustain continuity and promote a more stable and effective academic environment in times of political instability when post-election anxiety is addressed to the barest minimum.
Advancing analytical tools for RNA modification research by LC-MS
Authors:   , Ammann Gregor
Published: February 2025

Nucleotides in RNA are chemically altered to fulfill an array of different functions. These modifications play a crucial role in RNA function, translation regulation and human disease. Despite their significance for many biological processes, as of today, many aspects of RNA modifications are poorly understood. Part of the reason is the limited technology available to study and quantify modified nucleotides. For RNA modification quantification, the current gold standard is liquid chromatography cou-pled mass spectrometry (LC–MS) of nucleosides. For that, typically, the RNA of in-terest is purified, enzymatically hydrolyzed into nucleosides and finally subjected to LC–MS analysis. This workflow – when implemented properly – yields sensitive, accurate and precise results, however, it also suffers from some drawbacks: a) The technology has inherent limitations that can partially be compensated for by orthog-onal techniques, such as sequencing. Therefore, the field would benefit from innova-tion that diversifies questions that can be answered by nucleoside MS. b) Many steps along the workflow are very delicate and error-prone. Thus, a variety of artifacts and distortions may be introduced into a given analysis. In other words, extension and improvement of the analytical toolbox in the realm of nucleoside MS is warranted. In this thesis, I tackle both of the above-mentioned issues: First, I combined the stable isotope labeling strategies for proteins (commonly known as SILAC) with nucleic acid labeling in cell culture. This allows researchers to simultaneously analyze pro-teins and RNA by MS from one sample. Further, I carefully examined each step with-in the nucleoside MS workflow to uncover potential pitfalls, errors or artifact-generating circumstances. I identified three major classes of issues that may hamper accurate RNA modification quantification. The first class is related to the chemistry of individual nucleosides, the second one relates to the central enzymatic hydrolysis and, last but not least, the third class is connected to the instrumental analysis. This work will prevent future mistakes and thus strengthen the confidence in analytic re-sults obtained by nucleoside MS. Taken together, this thesis contributes to the field of RNA modification quantification by developing novel tools and improving exist-ing ones.
Quantum rotor in a two-dimensional mesoscopic Bose gas
Authors: Suchorowski Michał , Badamshina Alina , Lemeshko Mikhail , Tomza Michał , Volosniev Artem G.
Published: February 2025

We investigate a molecular quantum rotor in a two-dimensional Bose-Einstein condensate. The focus is on studying the angulon quasiparticle concept in the crossover from few- to many-body physics. To this end, we formulate the problem in real space and solve it with a mean-field approach in the frame co-rotating with the impurity. We show that the system starts to feature angulon characteristics when the size of the bosonic cloud is large enough to screen the rotor. More importantly, we demonstrate the departure from the angulon picture for large system sizes or large angular momenta where the properties of the system are determined by collective excitations of the Bose gas.
The effect of foreign shareholder ownership on labor investment efficiency: Evidence from South Korea
Authors: Chae Soo-Joon , Ryu Haeyoung
Published: February 2025

This study investigates whether higher foreign shareholder equity improves labor investment efficiency in South Korean publicly listed firms. Labor investment, like capital investment, plays a crucial role in shaping corporate performance and value. It involves continuous cash outflows and poses challenges during restructuring, such as downsizing. Foreign shareholders are known to take on a monitoring role in Korean firms, potentially leading to more efficient labor investment decisions.To assess the impact of foreign shareholder involvement on labor investment efficiency, regression analysis was conducted using data from 2,699 firm-year observations from firms listed on the Korean stock exchange during the pre-pandemic period (2016–2019). Labor investment inefficiency was measured as the absolute difference between actual and expected labor investment levels, considering both over- and under-investment as inefficiencies.The analysis revealed a significant negative relationship between foreign ownership and labor investment inefficiency. Specifically, a regression coefficient of –2.220 (p-value: 0.027) indicates that higher foreign shareholder equity is associated with lower labor investment inefficiency. Further analysis, separating the sample into over-investment and under-investment groups, found that the coefficient for foreign ownership in the under-investment group was –1.920 (p-value: 0.055), significant at the 10% level. These findings suggest that foreign shareholders, through their monitoring role, help reduce information asymmetry, decreasing inefficiencies in labor investment decisions.
The role of gender diversity, board size, and ESG disclosure in improving performance and managing risks
Authors: Muazaroh  , Lestari Wiwik , Purnama Sari Linda
Published: February 2025

This study analyzes the effect of gender diversity, board size, and environmental, social, and governance (ESG) disclosures on firm performance and risk management in the consumer goods sector in Indonesia, targeting companies listed on the Indonesia Stock Exchange from 2020 to 2022. Based on 273 cases and using partial least squares-structural equation modeling (PLS-SEM), this paper tests eight direct and moderating hypotheses. The results reveal that both gender diversity and board size positively impact firm value, while board size successfully reduces firm risk. However, gender diversity does not mitigate risks. The findings indicate that increasing board gender diversity and size are positively related to performance, while only board size contributes effectively to risk reduction. ESG disclosures play a moderating role, enhancing the synergy between gender diversity and performance but showing mixed effects on risk reduction. Overall, the study highlights the importance of integrating gender diversity and strong ESG practices to achieve better performance outcomes, improve transparency, and develop a more competitive corporate strategy.
AcknowledgmentThe author would like to thank the Higher Education Service Institute of Region VII of the Ministry of Education, Culture, Research and Technology and the Directorate of Research, Technology and Community Service, Directorate General of Higher Education, Research and Technology for funding this research with research contract number 076/SP2H/PT/LL7/2024.
Combined use advantages of nimesulide oral and local forms in pain syndrome treatment
Authors: Shavlovskaya O. A.
Published: February 2025

Nonsteroidal anti-inflammatory drugs (NSAIDs) are usually prescribed either locally (topical forms) at the first stage, or orally at the second stage, if the effect of local pain relief when using NSAIDs has not been achieved. The combined use of different forms with the same NSAID molecule will enhance and prolong the anti-inflammatory and analgesic effect, reduce the dosage of the oral drug, and thereby reduce the risks of adverse events (AE). Nimesulide is a representative of the sulfonanilide class among NSAIDs, refers to drugs that inhibit mainly the enzyme cyclooxygenan-2 (COX-2), and has no effect on COX-1. Selective COX-2 inhibitors are significantly less likely to cause the development of NSAID-gastropathies. Nimesulide is characterized by a low range of relative risks (RR) compared to other commonly prescribed NSAIDs: <2 for rofecoxib, celecoxib, nimesulide; from 2 to < 5 for naproxen, ibuprofen, diclofenac, etoricoxib, meloxicam; and ≥ 5 for ketoprofen, piroxicam, ketorolac. The anti-inflammatory and analgesic effect of nimesulide is achieved by inhibiting the release of tumor necrosis factor alpha (TNF-alpha), histamine, inhibiting the formation of reactive oxygen species, releasing matrix metalloproteases (MMPs), and inhibiting chondrocyte apoptosis. The clinical effectiveness of the analgesic effect of nimesulide has been proven in pain syndrome in patients with osteoarthritis (OA), lower back pain (LBP), gouty arthritis. The anti-inflammatory effect of nimesulide is manifested in the suppression of pro-inflammatory cytokines. Nimesulide has a low level of AE from the gastrointestinal tract (GIT), therefore it can be recommended for elderly patients.
Microrganismos presentes em uma kombucha artesanal gaúcha
Authors: Pizzato Alessandra Campani , De Araujo e Silva Giulia Bacim , Tósca Marina Borba , Bessa Marjo Cadó , Seidler Flávia , De Freitas Giovana Alves
Published: February 2025

A kombucha é uma bebida fermentada por uma cultura simbiótica de bactérias e leveduras microbiologicamente ativas (SCOBY) com propriedades apontadas como benéficas à saúde. Foi realizado estudo descritivo com kombuchas produzidas em escala em Porto Alegre/RS, sendo coletados amostras para o isolamento de microrganismos presentes na kombucha, bem como nos insumos utilizados (SCOBY e chá verde). As bebidas foram analisadas nas versões original e saborizada com e sem homogeneização, em triplicata, perfazendo um total de 12 amostras. Verificou-se que a kombucha apresentou elevada quantidade de leveduras, com diferença significativa da bebida conforme homogeneização, tanto na forma original homogeneizada (7.39±6.46 log UFC/mL vs não homogeneizada 6.46±5.39 log UFC/mL, p<0,0065) quanto na saborizada homogeneizada (7.54±6.81 log UFC/mL vs não homogeneizada 7.20±6.04 log UFC/mL, p<0,049). O SCOBY apresentou contagem total de leveduras de 6.78±6.68 log UFC/mL e no chá verde não foi observado o crescimento de microrganismos. Por fim, conclui-se que a kombucha analisada apresenta elevada quantidade de leveduras, tanto na bebida original quanto na saborizada, sendo a concentração maior desses microrganismos na forma homogeneizada, o que sugere a importância da leve homogeneização da bebida antes do consumo.
Edge Co-Even Domination
Authors: Demirpolat Nazlıcan Çağla , Kılıç Elgin , Omran Ahmed
Published: February 2025

Domination is one of those important parameters in graph theory which has a very wide range of applications. There are various types of domination depending on the structure of dominating sets. In this study, a new domination parameter called edge co-even domination number is introduced and denoted by γ_coe^' (G). Some basic graphs such as path, cycle, complete, complete bipartite, star, regular, wheel and their complement graphs are examined of this definition. In addition, some results of this parameter are found under graph operations, such as corona and cartesian product.
NVC-EMA Kopolimerinin ve Grafit ile Kompozitlerinin Hazırlanması, Karakterizasyonu, Termal ve Dielektrik Özellikleri
Authors: Barım Esra
Published: February 2025

Bu çalışmada, işlenilebilirlik ve termal kararlılık gerektiren uygulamalar için polimer kompozit malzemeler çalışılmıştır. Aynı zamanda, enerji depolama uygulamaları için dielektrik özellikleri araştırılmıştır. Bu amaçla poli(N-vinil karbazol-ko-etil metakrilat), P(NVC-ko-EMA), kopolimeri serbest radikal polimerizasyonu yoluyla sentezlenmiş, termal ve dielektrik özelliklerini geliştirmek için grafit (GR) ile kompozitleri hazırlanmıştır. Kopolimerin bileşimi 1H-NMR spektroskopisi ile belirlenmiş, yapılan hesaplamalar bileşiminde %56 NVC ile %44 EMA birimlerinin olduğunu ortaya koymuştur. P(NVC0.56-ko-EMA) ve kompozitlerinin DSC analizleri, polimerin 119.98 oC olan camsı geçiş sıcaklığının, grafit eklenmesi ile düştüğünü göstermiştir. TGA analizlerinde, polimere kıyasla grafit katkılı kompozitlerin termal kararlılıklarının daha yüksek olduğu görülmüştür. Hem kopolimerin hem de ağırlıkça %10 grafit içeren kompozitinin termal bozunma kinetiği Flynn-Wall-Ozawa (FWO) ve Kissinger-Akahira-Sunose (KAS) yöntemleriyle incelenmiştir. Hesaplamalar, GR katkılamasının kopolimerin termal ayrışma aktivasyon enerjisi değerini düşürdüğünü göstermiştir. Yapılan dielektrik ölçümlerinde, kompozitlerde artan GR konsantrasyonu ile dielektrik sabiti (Ɛ') ve dielektrik kayıp (Ɛ'') değerlerinin arttığı belirlenmiştir.
The Effect of Heavy Metals in Mining Emissions on Worker’s Blood Lead Levels: A Case Study of The Gumushane Zn-Pb Mine, Turkey
Authors: Bozbeyoğlu Pınar , Doğan Onur , Budak Burhan
Published: February 2025

The wastewater from mining facilities contains toxic elements such as arsenic (As), cadmium (Cd), chromium (Cr), manganese (Mn), zinc (Zn), and lead (Pb). If not disposed of correctly, it can lead to environmental pollution in case of accidents or overflow. Lead-zinc mining activities pose a significant risk of high blood lead levels (BLLs) among workers. Therefore, monitoring the blood lead levels of workers exposed to these heavy metals, especially lead, is crucial.
This study aims to determine the levels of potentially harmful elements in the wastewater dam of the largest Zn-Pb mine in the Black Sea Region. It also seeks to assess the environmental and human health risks comprehensively. Additionally, the study aims to establish a relationship between the levels of lead in the mining wastewater in Gumushane and the lead levels accumulated in the blood of workers exposed to this metal.
The study analyzed heavy metals such as As, Zn, Cu, Sb, and Pb in mining wastewater using Inductively Coupled Plasma – Mass Spectrometer (ICP-MS). The results indicated high levels of Pb in the studied wastewater. Furthermore, the blood lead levels of workers in the mining area (n=30; mean: 7.42 μg/dL) exceeded background levels (>40 μg/dL). These results suggest a significant relationship between the presence of lead in wastewater and high lead levels in the blood of individuals with high exposure to concentrated lead.
Nannospalax Kemirgenlerinde MTNR1A Genetik Varyasyonlarının Karakterizasyonu
Authors: Kankılıç Teoman , Civelek İlkay , Köse Burcu
Published: February 2025

Nannospalax cinsi üyesi körfareler toprakaltı ekolojik nişinde yaşamını sürdüren, düşük oksijenli ortama uyum sağlamış kemirgenlerdir. Olağanüstü uzun ömürleri ve hem spontan hem de indüklenmiş tümör oluşumuna karşı dirençleri ile karakterize edilen kemirgenlerdir. Bu kemirgenlerin kansere olan direncinin sebebi bilinmemekle beraber, yüzyıllardır yaşadıkları toprak altı nişinde sirkadiyen ritim veya bu yolakta görev alan genlerle ilişkili olacak şekilde bir kanser mekanizması geliştirebildikleri varsayılmaktadır. Bu çalışmada körfarelerde sirkadiyen ritimde ve melatonin yolağında görev alan MTNR1A genindeki varyasyonların varlığı ve tespit edilen varyasyonların veritabanındaki diğer türlere (Homo sapiens, Mus musculus, Heterocephalus glaber, Rattus norvegicus) ait dizilerle karşılaştırılması amaçlanmıştır. Bu amaçla, Türkiye’de dağılım gösteren dört Nannospalax türüne ait (Nannospalax xanthodon, Nannospalax ehrenbergi, Nannospalax leucodon ve Nannospalax tuncelicus) 9 farklı sitotip içeren toplam 18 adet örneğe ait dokulardan elde edilen DNA örneklerinin PCR analizi gerçekleştirilerek bu ürünler sekanslanmıştır. Sekans sonuçları ile referans genom (Nannospalax galili) karşılaştırılarak ilgili DNA baz farklılıkları tespit edilmiştir. Tespit edilen baz farklılıkları referans dizi ve diğer türlere ait amino asit dizileri ile karşılaştırılarak var olan/olması muhtemel varyasyonlar belirlenmiştir. Buna göre DNA dizilerindeki tek nükleotid değişimlerinden yalnızca biri amino asit dizisinde değişikliğe sebep olmuş; insanda 10. amino asite denk gelen p.N10Q (p.Asp10Glu) varyasyonu, Polyphen-2 veritabanında yaklaşık 0.5 skoru ile değerlendirilmiş ve mevcut değişimin muhtemel zararlı/patojenik etkileri olabileceği sonucuna varılmıştır.
Use of Vibration Spectroscopy in the Diagnosis of Gynaecological Tumours and Determination of Treatment Efficacy
Authors: Şahin Yılmaz
Published: February 2025

The aim of this study was to investigate the efficacy of radiotherapy in patients with gynecologic diagnosis and radiotherapy indications using vibrational spectroscopy as an alternative method to standard methods. Vibration spectroscopy is a non-invasive and sensitive technique for the diagnosis of gynecologic tumors and determination of treatment efficacy. This method analyzes biochemical components by examining the characteristic vibrational frequencies of molecules and includes techniques such as Raman spectroscopy and infrared (IR) spectroscopy. Raman spectroscopy analyzes protein, lipid and nucleic acid contents, with the capacity to identify biomolecular changes in cancerous tissues, while FTIR spectroscopy detects changes at the cellular level. Raman spectroscopy clearly revealed biochemical differences between cancerous and normal tissues. Significant changes in protein and lipid content were observed in cancerous tissues. CA-125 and HE-4 biomarker levels showed significant differences between before and after treatment. There was a strong correlation between spectroscopic data and biomarker levels. FTIR spectra were effective in identifying changes at the cellular level. Changes were detected in the FTIR spectra of cancer cells, especially in phospholipid and nucleic acid content.In conclusion, vibrational spectroscopy plays an important role as an alternative method to standard methods in the diagnosis of gynecologic tumors and determination of treatment efficacy, and its widespread use in clinical practice contributes significantly to successful outcomes in the management of gynecologic cancers.
Chemical Oxidative Polymerization of 1,3-Phenylenediamine Dichloride in Aqueous Solution: Synthesis and Characterization
Authors: Kolcu Feyza , Kaya İsmet
Published: February 2025

An aromatic diamine compound of 1,3-phenylenediamine dichloride (monomer), containing two polymerizable functional groups was submitted to selective polymerization in water via oxidative coupling polymerization with sodium hypochloride as the oxidant. Characterization of the synthesized polymer was performed utilizing UV-Vis, FT-IR, SEM, and photoluminescence techniques, identifying benzeneoid an quinoid units along the polymer chain. Based on the results of Gel Permeation Chromatography (GPC) analysis, the synthesized compound was identified as being in a polymeric form. The number of repeating units, as determined from Mw and Mn, was calculated as 151 and 86, respectively. Under visible light excitation, the polymer exhibited green light emission with a quantum yield of 11.2% in DMF. The monomer is oxidized via oxidative polymerization to a polymer with a higher electrochemical band gap. Scanning Electron Microscopy (SEM) revealed that the polymer particles with polyhedral and irregular sharp edges as well as spherical in the range from micro to nanometer in size were exhibited in the morphology of polymer.
Preparation, characterization and in vitro applications of morin hydrate loaded HPAC@MNPs nanocomposite
Authors: Baran Ayşe , Ertaş Erdal
Published: February 2025

Cancer is a prevalent and fatal illness that claims the lives of millions of people globally every year, impacting individuals across all age groups and ethnicities. Because drugs that are used to treat cancer affect both malignant and healthy cells without discrimination, they are responsible for systemic toxicity in addition to creating major adverse effects Recently, drug delivery systems that specifically target specific sites have been developed to minimize adverse effects caused by drugs. Morin (MRN) is a flavonol-based drugs that has been the subject of substantial research that has been conducted to investigate its antiangiogenic, anti-inflammatory, anticancer, and antibacterial activities. This study included the synthesis of a product with magnetic properties by applying a layer of magnetic nanoparticles onto biocompatible activated carbon derived from the hawthorn plant. Characterization of HPAC@MNPs synthesized with magnetic nanoparticle (MNPs) of activated carbon (AC) obtained from hawthorn plant (HP) was confirmed by Fourier Transform Infrared (FTIR), Scanning Electron Microscope (SEM), dynamic light scattering (DLS) and Zeta Potential. DLS analysis calculated the average particle size of HPAC@MNPs and HPAC@MNPs-MRN to be about 105 nm and 142 nm, respectively. The drug-loaded magnetic nanocomposite was evaluated for its cytotoxic effects on MCF-7 (breast), U373 (Glioblastoma) cancer cell lines, and Human Umbilical Vein Endothelial Cells (HUVEC) healthy cell line. The MRN loading and release characteristics of HPAC@MNPs were analyzed. The results indicated that the enclosed medication exhibited a prolonged spreading time during release. In summary, the use of HPAC@MNPs magnetic nanocomposite carriers may have great potential to effectively deliver MRN drugs to specific sites.
Vector Valued Multipliers of Invariant Means and Compact Summing Operators
Authors: Karakuş Mahmut
Published: February 2025

In notation of multiplier convergence, one can redefine the notion generalized Köthe-Toeplitz dual of a sequence space. Since the basis (e^n) of a sequence space N dominates the sequence (v_n)∈N^β, the β-(generalized Köthe-Toeplitz) dual of N can be represented as N^β={(v_n)|(e^n)> ̃(v_n)}. Employing usual terminology and concepts, in this paper, we introduce novel vector-valued multiplier spaces through the σ-summability method alongside a sequence of bounded linear operators. These spaces are equipped with the sup norm topology. Building on the foundational comprehension of completeness of normed spaces, we examine some properties of the summing operator S in detail, which acts between multiplier spaces and general normed spaces. This investigation entails a meticulous characterization of the operator's various properties. By examining these properties through the frameworks of some types of multiplier series, we deliver a thorough and refined analysis of the operator’s behavior, providing a more expansive and enriched perspective on its functional characteristics.
Türkiye’deki Jeotermal Suların Piper Diyagramı ile Sınıflandırılması ve Beton Üzerine Etkisi
Authors: Sağsöz Arif Emre , Caf Murat , Yildiz Ahmet Tuğrul , Polat Rıza
Published: February 2025

Dünyada teknolojik gelişmeler, artan nüfus, daha iyi yaşam tarzı arzusu ile eş zamanlı olarak enerji ihtiyacı da artmaktadır. Artan enerji ihtiyacı fosil yakıtlardan kaynaklı CO2 emisyonlarının artmasını da tetiklemektedir. Bu durumun önüne geçmek için sürdürülebilir, temiz, yenilenebilir enerji kaynaklarına yönelik talep gündeme gelmektedir. Güneş, rüzgâr, deniz, biokütle, jeotermal vb. kaynaklardan elde edilen enerjiler CO2 emisyonlarından kaynaklı sorunları azaltmakta ve daha sürdürülebilir ortam oluşturmaktadır. Jeotermal kaynaklar bakımından en zengin ülkelerden biri olan Türkiye’deki sular, sıcaklık, pH ve kimyasal içeriklerinden dolayı farklılık göstermektedir. Bu farklılıklar ise jeotermal suların kullanıldığı tesislerde beton esaslı malzemelerin servis ömürlerini etkilediği hem mevcut jeotermal tesislerde yapılan incelemeler hem de literatür araştırmaları sonucunda görülmektedir. Bu amaçla, Türkiye de bulunan jeotermal suların sıcaklık, pH ve kimyasal içerik bakımından sınıflandırılması yapılmıştır. Sınıflandırmada su kimyası grafiksel yöntemlerinden biri olan Piper Diyagramı kullanılmıştır. Sonuç olarak, Türkiye de bünyesinde sodyum, klor ve bikarbonat tip su barındıran kuyuların daha fazla olduğu, genellikle pH değerlerinin 10’un altında ve 20-240°C arasında farklı sıcaklıklara sahip oldukları görülmüştür. Jeotermal sular farklı ısı ve kimyasal özelliklerinden dolayı beton üzerinde genel olarak olumsuz olmak üzere kürleme, aşındırma, çökelme gibi farklı etkilere sahip olduğu değerlendirilmiştir.
Textural Monitoring of Ripening Process of Hayward Kiwi Stored with Apple and Quince
Authors: Karaoğlu Mehmet Murat , Hanoğlu Aslıhan
Published: February 2025

The possibility of using apple and quince in the natural ripening process of climacteric kiwi fruit, which takes a long time to ripen due to a low ethylene release level after harvest, was investigated. Kiwi samples were stored separately, accompanied by apple and quince at different storage temperatures (4⁰C and 20⁰C) and periods (15, 30 and 45 days) and examined in terms of textural properties. It was determined that storage process accompanied by apple decreased firmness, chewiness and gumminess values of kiwi samples. In contrast, the storage process accompanied by quince did not exhibit a significant decreasing effect on these values. Storage process at room temperature and increase in storage time led to decreases in textural parameters in general. The penetration force (137.25-1722.33 g) and penetration work values (352.40-6453.45 g.s) of samples mainly changed depending on firmness. A similar tendency was also observed in relaxation time (8.40-124.83 s), maximum force (1.05-77.50 N) and minimum force values (0.41-50.07 N). As a result, it has been determined that storage process accompanied by apple is a quite good option in the natural, fast and accessible ripening process of kiwi and provides approximately 28% general reduction in fruit firmness. Storage treatment accompanied by quince can be recommended for demands in which the current ripeness level of kiwi is desired to be kept. In addition, it has been concluded that in cases in which rapid ripening is required, the choosing of storage process at room conditions will be more suitable due to its ripening-promoting effect.
A Multidimensional Approach to Apricot Quality Assessment
Authors: Altıkat Alperay , Kaya Tuncay , Alma Mehmet Hakkı
Published: February 2025

In this study, physical, mechanical and color characteristics of five different apricot cultivars (Hacıhaliloğlu, White Apricot, Kabaaşı, Ordubat and Şalak) grown in Iğdır province of Türkiye were examined and the effects of the relationships between these characteristics on fruit quality and marketability were determined. While fruit width, height, thickness and weight values were examined as physical properties, penetration resistance against forces applied in horizontal and vertical directions were evaluated under the heading of mechanical properties. In addition, multiple component analysis and correlation analysis were applied to detail the relationships between these parameters. As a result of, it was determined that there were statistically significant differences in terms of physical, mechanical and color measurement values for all apricot cultivars. It was concluded that Şalak variety was larger than the other cultivars but more sensitive to mechanical forces. In general, the increase in the size of the apricots increased the deformation under load. As an expected result, the variety difference in apricots also affected the color characteristics. Considering consumer preferences, L* value, which is an indicator of brightness in fruits, has emerged as an important parameter in color measurements. PCA analyses were performed to determine the main components of variance in the data set and it was determined that apricot physical properties had a much more dominant role on this variance (78.39%). The effect of mechanical properties on the variance was calculated as 20.85%. The investigated apricot cultivars showed statistically significant differences in terms of physical, mechanical and colour properties. It was found that the Şalak variety was larger and heavier, but its mechanical resistance was lower.
Metilen Mavisinin Sulu Çözeltilerden Diospyros Kaki L. Kabuğuna Adsorpsiyonu: İzoterm ve Yapay Sinir Ağı Modellemesi
Authors: Reçber Züleyha
Published: February 2025

Bu çalışmada; metilen mavisi boyar maddesinin sulu çözeltilerden giderimi için Diospyros kaki L. kabuğunun adsorpsiyon potansiyeli incelenmiştir. Temas süresi, pH, adsorbent miktarı, başlangıç boya konsantrasyonu, sıcaklık ve karıştırma hızının boya giderim verimi üzerindeki etkileri araştırılmıştır. Adsorpsiyon 60 dakikada dengeye ulaşmıştır. Adsorbent miktarı arttıkça boya giderim verimi artarken adsorpsiyon kapasitesi düşmüştür. Başlangıç pH’sının sistem performansı üzerinde etkin bir parametre olduğu gözlemlenmiş ve en yüksek boyar madde giderim verimi pH 8’de elde edilmiştir. Adsorpsiyon mekanizmasını belirlemek için Langmuir ve Freundlich izoterm modelleri kullanılmış ve Freundlich izoterm modelinin deneysel verilere daha uygun olduğu tespit edilmiştir. 1 g/L adsorbent miktarı, 250 rpm karıştırma hızı, 100 mg/L başlangıç boyar madde konsantrasyonu, 25 ºC sıcaklık ve 6.68 pH’da 120 dakikalık temas süresinde %85.14’lük giderim verimine ulaşılmıştır. Sulu çözeltiden metilen mavi giderimini tahmin etmek için yapay sinir ağı modeli geliştirilmiştir. Xgboost algoritması ile en küçük ortalama kare hata (MSE) ve en büyük belirleme katsayısı (R2) değerleri sırasıyla 6.99 ve 0.99969 olarak belirlenmiştir. Sonuçlar Diospyros kaki L. kabuğunun metilen mavisi boyar maddesinin sulu çözeltilerden giderimi için etkili bir adsorbent olarak kullanılabileceğini ve yapay sinir ağının makul bir tahmin performansı sağladığını, geliştirilen yapay sinir ağı modeline dayalı simülasyonlar, farklı koşullar altında renk giderim sürecinin davranışını tahmin edebileceğini göstermiştir.
Innovative Design, Synthesis, and In Silico Evaluation of Bis-Ureido Substituted Antipyrine Derivatives: Molecular Modeling and ADME Insights
Authors: Akocak Süleyman
Published: February 2025

Molecular docking is a computational modeling technique that predicts the interactions between molecules of interest and certain protein structures. This approach estimates binding affinities and visualizes bond interactions, making it a useful tool for drug discovery. Molecular docking helps to rationally design new therapeutic medicines by offering insight into potential binding connections between molecular structures prior to laboratory testing. ADME investigations supplement molecular docking by assessing the pharmacokinetic features of the examined compounds, consequently determining their eligibility as possible therapeutic candidates. In this study, we show the creative design, synthesis, and In silico evaluation of a novel series of bis-ureido substituted antipyrine derivatives, with a focus on their potential as cholinesterase inhibitors. Using molecular modeling tools, we combined the bis-ureido group with the antipyrine drug to improve the pharmacological properties of these molecules. The newly synthesized compounds were comprehensively characterized by spectroscopic approaches, including FT-IR, ¹H-NMR, and ¹³C-NMR, followed by molecular docking experiments to analyze their interactions with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Additionally, In silico ADME assessments were performed to determine the compounds' pharmacokinetic characteristics and drug-likeness properties. Notably, compound 10 showed strong binding affinities against AChE and BChE, with binding energies of -14.47 and -11.75 kcal/mol, respectively. The docking data revealed high binding affinities, indicating a significant inhibitory potential for both AChE and BChE. This study points out the need of combining molecular docking and ADME investigations in contemporary pharmaceutical design and development.
Machine Learning-Based Tooth Color Assessment Using Color Moments to Prevent Metamerism in Different Clinical Lights
Authors: Efitli Esra , Karcıoğlu Abdullah Ammar , Şimşek Emrah , Özdoğan Alper , Karataş Furkan , Şenocak Tuba
Published: February 2025

Choosing the right shade in prosthodontic treatment is of great importance in terms of achieving a natural aesthetic appearance and increasing the patient's satisfaction with the treatment. However, this process is affected by many technical and environmental factors. In particular, variable light sources in clinical and laboratory environments cause the problem of metamerism, which leads to misleading results in color perception. This study proposes a method that reduces the effect of metamerism by detecting color under different light conditions, eliminates the subjectivity of traditional color matching methods and offers an alternative to costly measurement devices. The 29 color samples from the Vita 3D Master shade guide were imaged five times each in four different clinical light conditions. Feature extraction was performed using color moments in RGB, LAB and HSV color spaces. Experimental studies were carried out with different machine learning algorithms on the datasets created with these data. As a result, 100% accuracy was obtained for the classification of four clinical light conditions, 85% for the light-independent classification of 29 Vita colors, 100% under white light, 97% under natural light, 92% under flash light and 94% under yellow light. These findings demonstrated that the limitations of traditional or costly color selection processes can be overcome and metamerism can be reduced by machine learning techniques.
Narrativas da infância: práticas de ensino sob o olhar da criança
Authors:   , Nobre Ellen Cristina Maia
Published: February 2025

Esta pesquisa visa identificar posicionamentos de estudantes do Ensino
Fundamental acerca das práticas pedagógicas em salas de aula regular. Nos
debruçamos sobre os seguintes questionamentos: que valores são atribuídos pelas
crianças às ações de ensino? O que as inquietam durante o processo de ensino e
aprendizagem? Suas vozes são escutadas e levadas em consideração no ambiente
escolar? O objetivo situa-se em torno de compreender, nas narrativas de crianças
do Ensino Fundamental, quais os sentidos atribuídos às práticas de ensino em salas
de aulas regulares. A abordagem da pesquisa é de cunho qualitativo (BOGDAN;
BIKLEN, 1994), na qual ancora-se a pesquisa com narrativas autobiográficas que
nortearam a construção desta dissertação. Colaboraram oito crianças entre 8 e 12
anos de idade, alunos do 3º, 4º e 5º ano do Ensino Fundamental de uma escola
pública, localizada na cidade de Apodi, estado do Rio Grande do Norte. Os
procedimentos metodológicos foram desenvolvidos em quatro momentos que se
interrelacionaram. Para a coleta de dados, realizamos as atividades em formato de
cirandas, em três encontros com duração de tempo previsto entre quarenta minutos
até uma hora. As cirandas foram criadas no intuito de atender cada objetivo traçado,
as temáticas e práticas executadas nas mesmas foram pautadas da ludicidade a fim
de adentrar no mundo real e imaginário das crianças. Com base nos referenciais
estudados antes e no decurso da pesquisa, bem como nos elementos teórico-
metodológicos elencados, a análise dos dados centraram-se nas contribuições
teóricas de Passeggi (2016), Rocha (2014), Alves (2012), Freire (2013), Josso
(2010), Morin (2010), Jovchelovitch; Bauer (2002), dentre outros. Como achados,
destacamos a possibilidade e necessidade, cada vez mais emergente, de olhares
sensíveis para as falas das crianças. Afinal é, no mínimo, contraditório pensar numa
escola para crianças onde nela suas vozes não tenham visibilidade, onde muitos
têm dificuldades de percebê-las como sujeitos ativos e protagonistas do seu
processo de ensino. As vozes das crianças nos levaram, ainda, a problematizar o
silenciamento das crianças ao longo de sua vida escolar, bem como, intentar
compreender o modo como elas percebem as práticas de ensino, a partir de suas
próprias vivências e de suas narrativas. As crianças elencaram alguns valores
essenciais as práticas de ensino como: O afeto, a paciência, a compreensão, usar o
lúdico, saber interagir com o aluno e ter o domínio do conteúdo. Conforme os
participantes esses elementos são de grande importância para que possa aprender
de uma maneira significativa. Para elas, as inquietam tudo que a impede de ser,
tudo que rompe voos, o que aprisiona. A falta de empatia, de olhar sensível. De
planejamento. Tudo que ofusca o arco-iris, que para as crianças são elementos
essenciais ao professor: “paciência, compreensão, amor, alegria e diversão”