bluuebunny/crossref_metadata_2025 huggingface dataset:
Linear Synthesis of {4-[(2-Alkoxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones as Possible Therapeutic Agents
Authors: Muhammad Athar Abbasi Muhammad Athar Abbasi , Wajiha Khan Wajiha Khan , Aziz ur Rehman Aziz ur Rehman , Sabahat Zahra Siddiqui Sabahat Zahra Siddiqui , Ghulam Hussain Ghulam Hussain , Syed Adnan Ali Shah Syed Adnan Ali Shah , Muhammad Shahid and Khalid Mohammed Khan Muhammad Shahid and Khalid Mohammed Khan
Published: January 2022

In the present work, a series of {4-[(2-alkyloxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones was synthesized through a linear bi-step approach. The synthesis was initiated by the coupling of 2-furyl(1-piperazinyl)methanone (1) with 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (2) under dynamic pH control in aqueous alkaline medium to form parent compound, {4-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanone (3). Then, the O-substitution reaction on nucleophile 3 was carried out by treating it with different alkyl/aralkyl halides (4a-l) in the presence of lithium hydride (LiH) and N,N-dimethylformamide (DMF) to obtained the designed {4-[(2-alkoxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones (5a-l). These synthesized compounds were screened against α-glucosidase enzyme and some of them exhibited considerable inhibitory activity. Additionally, compounds were also evaluated for hemolytic and cytotoxic profile.
Potential of Carica papaya Waste for the Production of Alginic Acid by Fermentation
Authors: Sobia Saeed Sobia Saeed , Shagufta Saeed Shagufta Saeed , Faiza Masood Faiza Masood , Sehrish Firyal and Muhammad Tayyab Sehrish Firyal and Muhammad Tayyab
Published: January 2022

The commercially available alginic acid is mainly extracted from sea weeds. Owing to the growing demand and variation in composition of alginate extracted from different species, there is rising interest in synthesis of alginate by bacteria. Therefore, present research was designed with the aim to check the potential of different papaya wastes like peels, seeds and decayed pulp for alginate production by Azotobacter vinelandii. Optimization of physico-chemical parameters was also done. Highest amount of the biopolymer was reported on fermentation of papaya peel at 72 hours of incubation period with inoculum size of 6% (v/v), at pH 7.0, 300C and agitation intensity of 200 rpm. Among different carbon and nitrogen sources tested, sucrose and peptone increased the yield of biopolymer (5.34 g/L). Alginate obtained was 98% pure in comparison to the standard. The present research is the first report on utilization of cheap papaya waste for alginate production and will be helpful to save the foreign exchange.
Synthesis, Spectral Characterization and Biological Evaluation of Organotin(IV) Complexes of Aniline Derivatives of Naturally Occurring Betulinic Acid
Authors: Sabiha Khanam Sabiha Khanam , Khadija Shahid Khadija Shahid , Muhammad Sirajuddin Muhammad Sirajuddin , Saqib Ali and Hameed Ullah Saqib Ali and Hameed Ullah
Published: January 2022

Betulinic acid (triterpene) has shown an immense potential towards the development of anticancer, antiviral, antimalarial, antifungal, antioxidant and antiprotozoal agents. Cis-platin (cytotoxic agent) has diverted attention of chemists towards organotin complexes with marked pharmacological activities. In present work aniline derivatives of Betulinic acid were synthesized followed by the synthesis of diorganotin and triorganotin metal complexes. These complexes were characterized by FT-IR and multinuclear NMR (1H and 13C) spectroscopy. The ligands and their organotin(IV) complexes were screened for antibacterial, antifungal and antioxidant activities. Compound L22SnMe2 was found with maximum antibacterial activity among the screened compounds. Compounds L12SnMe2 and L12SnPh2 were found with remarkable antifungal activity. Similarly L1, L12SnBu2, L2 and L22SnMe3 were remarked with good antioxidant activity.
The Selective Oxidation of Hydrocarbons on Isolated Iron Active Sites under Ambient Conditions
Authors: Zhengliang Qi Zhengliang Qi , Junmei Liu Junmei Liu , Wanwan Guo and Jun Huang Wanwan Guo and Jun Huang
Published: January 2022

The N-doped carbon material supported Fe catalysts were developed for the oxidation of C-H bond of hydrocarbons to ketones and alcohols. The supported Fe catalysts were prepared by pyrolysis of [CMIM]3Fe(CN)6 ionic liquid in activated carbon. And the Fe(Ⅲ)@CN-600 showed good activity and high selectivity for the oxidation of alfa C-H bond of alkylbenzenes. The isolated Fe(Ⅲ) iron active sites should be responsible for the high activity and selectivity for the oxidation of hydrocarbons to ketones. Several ketones were obtained in good to excellent yields. Moreover, cyclohexanone can also be obtained through the oxidation of cyclohexane.
New Ferrocene Based Thiourea and Guanidines: Synthesis, Structural Elucidation, Aggregation Properties, DNA Binding Studies, and DFT calculations
Authors: Maria Azeem Maria Azeem , Jahangeer Ali Patujo Jahangeer Ali Patujo , Saira Fatima Saira Fatima , Amin Badshah Amin Badshah , Laiba Saleem and Saif ur Rehman Laiba Saleem and Saif ur Rehman
Published: January 2022

One new ferrocenyl thiourea and four new ferrocene-based alkyl guanidines have been successfully synthesized and well characterized by FT-IR, 1H and 13C NMR. Aggregation properties of ferrocene-based guanidines have been assessed by determining their critical micelles concentration through tensiometry and UV-Visible spectroscopy in the ethanol solution. The results obtained through both the techniques were in close agreement. DFT calculations were performed to calculate the charges distribution, EHOMO, ELUMO and band gaps of synthesized compounds which were further supported through UV-Visible spectroscopy. Due to the ability of ferrocene and guanidine compounds to bind with DNA, their DNA binding studies were performed through cyclic voltammetry and UV-Visible spectroscopy. Binding constant values of the guanidine derivatives are higher than the thiourea and have a linear dependence on the lipophilicity.
Development of Extractive Spectrophotometric Methods for the Determination of Iron(III) with Dimercaptophenole and Heterocyclic Diamines
Authors: Kuliev Kerim Avaz Kuliev Kerim Avaz , Verdizade Nailya Allahverdi and Mamedova Shafa Aga Verdizade Nailya Allahverdi and Mamedova Shafa Aga
Published: January 2022

Dimercaptophenole (DM) is proposed as a new sensitive reagent for the sensitive extractive spectrophotometric determination of Fe(II). DM in the presence hydrophobic amins reacts with Fe(II) in the pH range 5.3 -7.2 to form a coloured complex. Chloroform, dichloroethane, and carbon tetrachloride appeared to be the best extractants. The absorption spectrum of Fe (II)-DM-Am complexes in chloroform shows maximum absorbance at 552-583 nm. It was observed that the color development was instantaneous and stable. Linear calibration graphs were obtained for 0.03-4.2 μg mL −1 of Fe.The molar absorptivity calculated was found to be (3.08-4.33) and#215; 104 dm3 mol−1 cm−1 and the sensitivity of the method as defined by sandaland#39;s was 1.29-1.82 ng cm-2. The stoichiometry of the complex is established as 1:1:2 (M : L : Am) by equilibrium shift method, and confirmed the methods of relative yield, Asmus straight line and the intersection curves. It may be satisfactorily applied for the determination of Fe(III) with present method. The results of the prescribed procedure applied for the determination of the micro amounts of iron in pharmaceutical, biological, water, food and in plant samples are presented.
Новые находки Alcidodes karelinii (Boheman, 1844) (Coleoptera: Curculionidae) в Ставропольском крае
Authors: Козьминых Владислав Олегович
Published: January 2022

Приведены данные о находках адвентивного вида долгоносика Alcidodes karelinii (Boheman, 1844) (Coleoptera: Curculionidae) в Ставропольском крае. A. karelinii собран в июле и августе 2011, 2014, 2015 и 2020 гг. на разнотравной залежи, на краю поля с подсолнечником, в робиниевой лесополосе, в сорном разнотравье культурных участков. Материал собран методами энтомологического кошения и линий почвенных ловушек. Вид в регионе встречается спорадически, в местах обитания малочислен. Новые находки дополняют данные о распространении A. karelinii в Предкавказье.
О НЕКОТОРЫХ ЛОКАЛЬНЫХ БИФУРКАЦИЯХ ОБРАТИМЫХ КУСОЧНО-ГЛАДКИХ ДИНАМИЧЕСКИХ СИСТЕМ НА ПЛОСКОСТИ
Authors: Ройтенберг В.Ш.
Published: January 2022

Рассматривается двухпараметрическое семейство кусочно-гладких векторных полей на плоскости, «сшитых» из гладких векторных полей, определенных в верхней и нижней полуплоскостях. Векторные поля семейства предполагаются обратимыми относительно инверсии, для которой линия разрыва поля у=0 состоит из неподвижных точек. При нулевых значениях параметров векторные поля, определенные в верхней и нижней полуплоскостях имеют в начале координат О касание третьего порядка с осью х. Описаны бифуркации фазовых портретов в окрестности точки О  при значениях параметров, близких к нулю.
О СУЩЕСТВОВАНИИ РЕШЕНИЯ ПЕРИОДИЧЕСКОЙ КРАЕВОЙ ЗАДАЧИ ДЛЯ ПОЛУЛИНЕЙНЫХ ДИФФЕРЕНЦИАЛЬНЫХ ВКЛЮЧЕНИЙ ДРОБНОГО ПОРЯДКА ИЗ ИНТЕРВАЛА (3, 4) В БАНАХОВЫХ ПРОСТРАНСТВАХ
Authors: Петросян Г.Г. , Сорока М.С.
Published: January 2022

В работе исследуется периодическая краевая задача для класса полулинейных дифференциальных включений дробного порядка из интервала (3,4) в банаховом пространстве, для которых многозначная нелинейность удовлетворяет условию регулярности, выраженному в терминах мер некомпактности. Для доказательства существования решения задачи конструируется соответствующая функция Грина. Затем вводится в рассмотрение многозначный разрешающий оператор в пространстве непрерывных функций. После чего поставленная задача сводится к задаче существования неподвижных точек разрешающего мультиоператора. Для доказательства существования неподвижных точек используется обобщенная теорема типа Б.Н. Садовского.
РАСПРЕДЕЛЕНИЕ ВЕРОЯТНОСТЕЙ КРИТИЧЕСКИХ НАПРЯЖЕНИЙ РАЗРЫВА ОБРАЗЦОВ ПОРИСТОГО МАТЕРИАЛА
Authors: Вирченко Ю.П. , Шаполова И.М.
Published: January 2022

В рамках феноменологических общефизических представлений строится статистическая модель для описания условий зарождения таких микротрещин в объемных образцах пористых твердотельных материалов, которые под действием приложенной одноосной внешней нагрузки приводят к поперечному разрыву. На основе этой модели вычислена вероятность разрыва образцов как функция концентрации, находящихся в них пор.
Генезис спорта: обзор основных теорий
Authors: Лукащук Виталий Игоревич
Published: January 2022

Рассмотрены основные теоретические подходы к анализу генезиса спорта как социального феномена. Показано, что современные формы существования спортивных практик связаны с эволюцией социально-экономических отношений, складывающихся на том или ином этапе исторического развития общества. Появление в социальной среде новых форм спортивных практик обусловлено формированием специфических общественно значимых потребностей. Проанализированы различные направления эволюции спорта: социально-экономический, религиозный, игровой, культурный, воспитательный, образовательный, технологический. Отмечено, что заметное место при анализе социального аспекта развития спорта занимают работы, в которых рассматриваются детерминанты становления и функционирования его как зрелища. Показано, что в современных условиях зрелищный спорт становится формой профессионально организованного взаимодействия, приобретая черты искусства как специфической формы общественного мнения. При этом изменяется его социальный статус и социальные функции. Согласно законам шоу-бизнеса, современный спорт стремится максимально расширить свою потенциальную аудиторию, диверсифицировать свою структуру, находя все новые и новые виды соревнований.
Strength Calculation of UAV‘s Wing Connector Tube
Authors:   Armed Forces Academy of General M. R. Štefánik, Popardovská Eva , Popardovský Vladimír , Novotný Lukáš ,   Armed Forces Academy of General M. R. Štefánik,   Armed Forces Academy of General M. R. Štefánik
Published: January 2022

The use of unmanned vehicles - both civilian and military - is clearly a technological trend today. It is reasonable to assume that this trend will continue in the future. Especially in the military field, an unmanned vehicle can be considered a benefit, especially in applications where the use of "standard" equipment is difficult or impossible. This is especially true of Unmanned Aerial Vehicle (UAV). The flight itself represents a number of different types of stress affecting the design of the unmanned aircraft. Therefore, the design of such a device must be subjected in the first step to a computational strength analysis and subsequently to a real stress test. Our paper deals with the strength analysis of the most exposed structural element - the wing connector. Proper sizing of the wing connector is therefore crucial for the successful operation of the UAV.
Tribodiagnostic Control of Motor Oil (MO) Properties in IVECO Crossway Buses
Authors:   Armed Forces Academy of General M. R. Štefánik, Marko Miroslav , Kadlub Vladimír ,   Armed Forces Academy of General M. R. Štefánik
Published: January 2022

Within the Project VV1 "Design and application of tribodiagnostic methodologies for operation and maintenance of ground equipment of the Armed Forces of the Slovak Republic in the years 2018 - 2020, she was performed motor oil (MO) sampling series and property measurement series (MO) PETRONAS URANIA FE LS, SAE 5W-30, (O-1178), in IVECO CROSSWAY vehicles. The aim was to perform on the basis of the performed experimental measurements experimental verification of parameters of operating substances and materials of newly introduced ground military equipment.
Parametric analysis of dry machining process using a novel integrated multi-attribute decision making approach
Authors: Kumar G. Venkata Ajay , Ramaa A. , Shilpa M.
Published: January 2022

In most of the machining processes, the complexity arises in the selection of the right process parameters, which influence the machining process and output responses such as machinability and surface roughness. In such situations, it is important to estimate the inter-relationships among the output responses. One such method, Decision-Making Trial and Evaluation Laboratory (DEMATEL) is applied to study the inter-relationships of the output responses. Estimation of proper weights is also crucial where the output responses are conflicting in nature. In the current study, DEMATEL technique is used for estimating the inter-relationships for output responses in machining of EN 24 alloy under dry conditions. CRiteria Importance Through Inter-criteria Correlation (CRITIC) method is used to estimate the weights and finally the optimal selection of machining parameters is carried out using Techniques for Order Preference by Similarity to an Ideal Solution (TOPSIS) method. The model developed guides the decision maker in selection of precise weights, estimation of the inter relationships among the responses and selection of optimal process parameters.
Influence of lead acetate on seed germination and growth of young alfalfa plants
Authors: Andjelkovič Snežana , Babić Snežana , Milenković Jasmina , Zornić Vladimir , Prijović Miladen , Bekčić Filip , Papovič Olivera
Published: January 2022

This study presents the results of testing the effect of different concentrations of lead-acetate on seed germination and young Seedlings of alfalfa. Тhe experiment was organized so that in the first variant, only lead-acetate of different concentrations (10-5, 10-4, 10-3, 10-2 and 2 x 10-2 M) was used, and in the second, next to the lead acetate EDTA concentration of 0.012 % was added. The results of this study in which natural conditions are imitated showed that the percentage of alfalfa seed germination decreases with increasing lead-acetate concentrations. In a medium of high concentration of lead acetate 10-2 and 2 x 10-2, a small number of seeds (39% and 32 (32%) germinated. In the same treatments with EDTA, the toxic effects of lead acetate were reduced, and seed germination was better (59% and 43% seeds germinated). It has been noticed that lead has toxic effects on the growth of alfalfa roots and stems. In the variant in which EDTA was used, the negative influence of lead on and growth of alfalfa seedlings was significantly mitigated.
Sustained ophthalmic delivery of pH triggered Cromolyn sodium in situ gel
Authors: Subramanian S. , Prasanth B.
Published: January 2022

The research study intends to formulate pH triggered in situ gel of Cromolyn sodium composed of Polyacrylic acid (carbopol 934) polymer in combination with Hydroxypropyl Methylcellulose (HPMC K4M) polymer at 1:1, 1.5:1, 2:1 molar ratio by utilizing pH trigger method. Formulations were evaluated for pH, viscosity, gelling capacity, drug content and in vitro drug release. Results of Carbopol 934 and HPMC K4M based in situ gelling systems at 1:1, 1.5:1, 2:1 shown that the formulations were fluid state at room temperature in a formulated pH (pH 4.5) and went through fast progress into the viscous gel phase at the pH of the tear fluid 7.4. The viscosity of formulated pH triggered in situ gel at 2:1 molar ratio shown excellent result compares to 1:1, 1.5:1 molar ratio. The in vitro drug release of the developed in situ gelling formulations at 1:1, 1.5:1, 2:1 molar ratios increases the contact time and showed a non – fickian diffusion type of release behavior with 94.45%, 83.26%, 70.48% respectively over 8 hours periods compared with that of marketed formulation that shows 99.4% over 4 hours. Thus, the developed system at 2:1 molar ratio acts as a viable alternative to conventional eye drops and also prevent the rapid drainage.
Synthesis, characterization and biological activity of Pyrazoline derivatives
Authors: Kumar Jain Saras , Singhal Rohit , K. Jain Neetesh
Published: January 2022

Pyrazoline is dihydropyrazole having only one endocyclic double bond. Synthesis of pyrazoline derivatives from chalcones is an active arena of investigation due to established pharmacological result. In present study, chalcones were prepared by reacting of acetophenone with benzaldehyde. Then prepared chalcones react with isoniazid in the presence of glacial acetic acid results pyrazoline derivative. Physical parameters such as color, crystal structure, solubility, melting point, retardation factor (Rf) and % yield was evaluated. Confirmations of structures of all synthesized derivatives, were done by spectroscopic data of IR, 1HNMR and Mass spectroscopy. Also, all synthesized compounds were evaluated for antibacterial activity against B. subtilis, S. aureus, P.aeruginosa and E.coli, and antifungal activity was accomplished against C. albicans and A. niger at the different conc. and concluded that some compounds have excellent antimicrobial activity and most of the synthesized compounds exhibits moderate antimicrobial activity.
In Silico Study of Secondary Structure of Hemoglobin Protein
Authors: Chandra Roma
Published: January 2022

Protein structure prediction is one of the important goals in the area of bioinformatics and biotechnology. Prediction methods include structure prediction of both secondary and tertiary structures of protein. Protein secondary structure prediction infers knowledge related to presence of helixes, sheets and coils in a polypeptide chain whereas protein tertiary structure prediction infers knowledge related to three dimensional structures of proteins. Protein secondary structures represent the possible motifs or regular expressions represented as patterns that are predicted from primary protein sequence in the form of alpha helix, betastr and and coils. The secondary structure prediction is useful as it infers information related to the structure and function of unknown protein sequence. There are various secondary structure prediction methods used to predict about helixes, sheets and coils. Based on these methods there are various prediction tools under study. This study includes prediction of hemoglobin using various tools. The results produced inferred knowledge with reference to percentage of amino acids participating to produce helices, sheets and coils. PHD and DSC produced the best of the results out of all the tools used.
Evaluation of Antiepileptic activity of Mosapride in Albino wistar rats
Authors: Jain Shubhika , Chogtu Bharti , Krishna Vybhava , Khadke Isha
Published: January 2022

Serotonin causes a significant shift in the excitability of neurons and endogenous serotonin and drugs acting on serotonergic receptors play a role in pathogenesis of epilepsy. This study was done to study the effect of Mosapride, a serotonin receptor 5HT4 agonist, in animal models of epilepsy. Albino Wistar rats were divided into 5 groups with six animals in each group. Group 1 was control group, group 2 was standard group and group 3, 4 and 5 received test drug mosapride in low dose (3mg/kg), high dose (6mg/kg) and mosapride plus standard antiepileptic drug respectively. The antiepileptic efficacy was evaluated using Maximal Electroshock Seizure model (MES) and Pentylenetetrazole (PTZ) induced convulsions. Data was analysed using ANOVA followed by post hoc Tukeys test. Mosapride treated animals showed statistically significant decrease (p<0.001) in the duration of flexion, hind limb extension and post ictal depression in MES model which was comparable to phenytoin group. In PTZ model, mosapride alone did not show any significant difference as compared to control group in terms of latency and duration of seizures (p>0.05). The antiepileptic efficacy of mosapride is similar to phenytoin in MES model. However, in PTZ model mosapride did not show any beneficial antiepileptic effect
Comparing the Physico-Chemical Characteristics of Formulated and Marketed Yashada Bhasma
Authors: Bhatnagar Nitu , Pareek Avani
Published: January 2022

The present study is aimed to observe the difference in the Physico-Chemical characteristics of the marketed and formulated bhasma samples through X-Ray Diffraction analysis (XRD), Dynamic Light Scattering (DLS), Zeta potential, Thermo-Gravimetric analysis (TGA), Scanning Electron Microscopy (SEM) and Energy Dispersive X-Ray analysis (EDAX), apart from organoleptic methods. Inductively Coupled Plasma Mass Spectroscopy (ICPMS) analysis was also done to observe the presence of trace and heavy metals so that the safety of all these samples could be ensured. XRD shows variation in oxide nature of zinc as well crystallite size in all bhasma samples. DLS and SEM results show difference in particle size of marketed bhasma samples as compared to formulated Yashada bhasma. EDAX and ICPMS also confirm the alteration in elemental composition of all these bhasma samples. Thus, it can be concluded that these ayurvedic medicines should be prepared strictly using the formulation methods as mentioned in the Ayurvedic texts. This will help the prepared products to adopt the inherent quality of the ancient system of medicine, which shall be useful and devoid of any side effects for human consumption.
KUNDUSUK ROCK ART SITE: THE RESULTS OF 2020 STUDY
Authors: Заика А.Л. , Ключников Т.А. , Гурулев Д. А.
Published: January 2022

Писаница Кундусук - уникальный объект наскального искусства в горах Западного Саяна. Наскальные рисунки обследованы авторами в 2020 г. Скала с рисунками находится на правом берегу реки Амыл. Выявлено 16 камней с изображениями антропоморфных лиц без контура «джойского» типа. Датируются рисунки эпохой ранней бронзы и отражают художественные традиции окуневской культуры. Объект маркирует один из центров как сухопутных, так и речных древних коммуникаций. Памятник, видимо, являлся древним культовым местом. Здесь совершались ритуальные действия и минеральной краской изображались антропоморфные объекты поклонения для успешного преодоления речных и других препятствий. Лица могли отражать облик духов места, реки, маркировать этнокультурную принадлежность древних художников.

Kundusuk rock art site (“Pisanitsa Kundusuk”) is a unique object of rock art in the Western Sayan Mountains. The rock drawings were examined by the authors in 2020. The rock with the drawings is located on the right bank of the Amyl River. Sixteen stones with images of anthropomorphic faces without the contour of the “Dzhoi” type were revealed. The drawings date back to the early Bronze Age and refl ect the artistic traditions of the Okunev culture. The object marks one of the centers of both land and river ancient communications. Apparently, the site was an ancient cult place. Here ritual actions were performed and anthropomorphic objects of worship were depicted with mineral paint to successfully overcome river and other obstacles. Faces could refl ect spirits of a place, a river, mark the ethno cultural identity of ancient artists.
NEW PETROGLYPHS OF THE TEPSEI (ON THE RESULTS OF THE RESEARCH 2019-2020)
Authors: Советова О. С. , Шишкина О. О. , Аболонкова И. В.
Published: January 2022

В статье вводятся в научный оборот ранее неизвестные наскальные изображения Тепсейского археологического микрорайона (Краснотуранский район Красноярского края), выявленные в последние годы кемеровскими археологами. Новые рисунки обнаружены в разных участках микрорайона, благодаря крупномасштабным разведкам и использованию современных методов документирования памятников наскального искусства. Выявленные изображения относятся к разным хронологическим периодам, выполнены в технике выбивки, гравировки и прошлифовки. Новые рисунки Тепсейского микрорайона дополняют представления об изобразительных традициях, существовавших в Минусинской котловине на протяжении нескольких тысяч лет.

The article introduces into scientifi c circulation previously unknown rock images of the Tepsei archaeological area (the Krasnoturansk District of the Krasnoyarsk Region), which were revealed in recent years by Kemerovo archaeologists. New drawings were discovered in diff erent parts of the area due to large - scale explorations and the use of modern methods of documenting rock art sites. The identifi ed images belong to diff erent chronological periods, and are made in the technique of embossing, engraving and grinding. The new drawings of the Tepsei area enlarge the ideas about the pictorial traditions that have existed in the Minusinsk Basin for several thousand years.
THE IMAGE OF A HORSE - AS A SYMBOL (ON THE EXAMPLE OF EPIC "MANAS")
Authors: Бакчиев Т. А.
Published: January 2022

В статье основное внимание автора сконцентрировано на образе боевого коня, который стал частью традиционного мировоззрения. Символы, присутствующие в образе боевого коня, являются источником ценной информации, которые требуют глубокого изучения и через которые можно понять и оценить значение и роль коня в жизни кыргызского народа. В частности, цветовые символы, которые позволяют более полно раскрыть семантику образа боевого коня в эпосе «Манас». Эмпирической базой послужил кыргызский героический эпос «Манас».

In this article, the author refers to the Kyrgyz heroic epic "Manas". Turning to this epic, the author's main attention is focused on the image of a war horse, which has accompanied the people for thousands of years and has become part of their traditional worldview. The author of the article sets himself the goal of assessing the relevance of this problem, as currently existing in manas studies, counting on the fact that the symbols present in the image of a war horse are a source of valuable information that requires deep study, and through which it is possible to understand and evaluate the meaning and the role of the horse in the life of the Kyrgyz people. And the author turns his attention to color symbols that can reveal the hard - to - reach sides of the image of a war horse in the epic "Manas".
THE MOTIF OF RETURN IN D.KAINCHIN'S WORKS: RETURN AS DEATH, DEATH AS RETURN, DEATH ON THE NATIVE LAND
Authors: Модорова А. П.
Published: January 2022

В статье рассмотрена специфика мотива возвращения в творчестве алтайского писателя - Дибаша Каинчина. Были выделены следующие аспекты мотива возвращения, которые отображают религиозно - мифологические представления алтайского народа о смерти: во - первых, возвращение как смерть - это качественное изменение статуса героя после путешествия в «чужую» сторону; во - вторых, смерть как возвращение - это метафоричное «возвращение» души на свою родину; и в - третьих, возвращение осуществляется с целью доживания оставшейся жизни на родине (Алтае) с последующим после смерти захоронением на этой земле. В конечном итоге все эти аспекты описывают последовательно один процесс, приводящий к одному результату, который должен быть достигнут героем: вернуться на родину живым или неживым. Автор статьи приходит к выводу, что в произведениях Дибаша Каинчина отображается менталитет алтайского народа, отношение к смерти, представления о ней, насколько важно для алтайца вернуться домой и закончить свой жизненный путь на родине, а если смерть настигает на чужбине, то происходит метафоричное «возвращение» души на Алтай.

The article considers the specifics of the return motif in the literature works of the Altai writer Dibash Kainchin. We highlighted some aspects of the return motif, which reflect the religious and mythological ideas about death of the Altai people: first, return as death is a qualitative change of the hero's status after traveling to a "foreign" side; second, death as return is a metaphorical "return" of a soul to its homeland; and third, return to live out the rest of life on their native land (Altai) with subsequent burial on this land after death. In the end, all these aspects describe one process in sequence, leading to a single result that must be achieved by a hero: to return to his homeland alive or dead.
Scientific Research on Malaria: A Bibliometric Analysis in Latin America, 2011-2020
Authors: Briceño-Gómez Camila , Tapia-Sequeiros Gustavo , Torreblanca-Rodriguez Sebastian Martín , Valdivia-Vargas Lizbeth , Aquino-Canchari Christian Renzo
Published: January 2022

Introduction: Malaria is a protozoan disease that continues to be a serious public health problem in Latin America. The goal was to describe the scientific production of malaria in Latin America during the period 2011-2020. Materials and methods: Bibliometric study. A systematic search was carried out in Scopus, articles in IMRD format carried out in humans with malaria as the main variable were included, during the period 2011-2020. Results: 1731 malaria articles were found in Scopus, of which 590 (34.08%) were included according to the selection criteria. Scientific publication increased from 2011 to 2020 by 147.22%. It was found that 415 (70.33%) studies were published in Q1 journals and 141 (23.9%) published in Malaria Journal. Likewise, 506 (85.76%) studies were written in English language and the most influential funding entity was the Conselho Nacional de Desenvolvimento Científico e Tecnológico 117 (11.44%). In 271 (45.93%) studies, the corresponding author had Brazilian affiliation, and in 53 (8.98%) articles the Fundação Oswaldo Cruz predominated. Regarding the design, 274 (46.44%) studies were descriptive, 260 (44.07%) were epidemiological and 286 (48.47%) were carried out with people from the community. Latin American scientific production on malaria has increased; there is predominance in Q1 journals, with Malaria Journal being the most important. Most of the studies are descriptive related to epidemiology. Efforts are required to increase scientific production in the rest of the Latin American countries with a high prevalence of malaria
Regla de predicción para determinar infestación canina por Echinococcus granulosus
Authors: Montalvo Raúl , Nuñez Vladimir , Quiñones Pilar , Balbin Javier , Huiza Alina , Ochoa Salome , Montalvo Jorge
Published: January 2022

Nuestro objetivo fue determinar un score que ayude a predecir la probabilidad de infestación canina por Echinococcus en una zona endémica en hidatidosis. Se realizó un estudio longitudinal en 3 anexos de la provincia de Concepción ubicado en los andes centrales de Perú. La infección canina por Echinococcus granulosus fue definido por la presencia de antígeno identificado en la muestra de heces. El modelo predictivo se obtuvo mediante un análisis de regresión logística basado en los parámetros sociodemográficos, esta regla fue internamente validada por remuestreo de tipo bootstrap. Resultados: De 152 canes que se sometieron al estudio de heces, 76 tuvieron infección por Echinococcus confirmada por antígeno reactivo. Se identificaron 4 factores ponderados dentro de la regla de predicción que, en suma, dieron el puntaje: El can que duerme fuera de casa (3 puntos), alimentar con vísceras crudas al can (3 puntos) y sacrificar al ganado dentro de la casa (2 puntos) y el can se alimenta con croquetas (-2 puntos). Se encontró que esta regla de predicción tuvo valor del área bajo la curva ROC 0,78; (IC 95%: 0,70 – 0,86). Estos parámetros de predicción con un puntaje ≥ 3 tenía una sensibilidad del 75% y especificidad del 65,8%, con un valor predictivo positivo del 85,3%. Esta regla ayudará al personal de la salud a identificar a los canes infestados por Echinococcus granulosus, para su intervención anti parasitaria y preventiva en sus dueños.
El pH salival y microbiota oral: influencia en la salud bucodental de mujeres de 45 a 55 años
Authors: Villacreses Medina Mary Elena , Camaño Carballo Liset , Granda Macías Luz Amelia , Rodríguez Cuellar Yaima
Published: January 2022

Nuestra cavidad bucal cuenta con características particulares como ecosistema y microbiota. Este hábitat de microorganismos es uno de los más diversos de cualquier comunidad microbiana asociada a los humanos, y además cumple ciertas funciones en los procesos biológicos y digestivos del hospedante. Aunque muchos de estos microorganismos residentes aportan beneficios, en condiciones de sinergia y exacerbación, el predominio de algunos géneros puede influir en el desarrollo de enfermedades periodontales. Se realizó una investigación cuantitativa, exploratoria, descriptiva y transversal en el de Centro de Salud de Latacunga, provincia de Cotopaxi, en Ecuador, en mujeres cuya edad oscilaba entre 45 y 55 años. Se estableció una relación lineal negativa entre la edad y el pH salival, es decir, que al aumentar la edad aumentó la acidez bucal de las pacientes. De manera similar, el pH salival influyó inversamente en la disponibilidad microbiótica, pues en las cavidades bucales más ácidas el índice de detección fue más alto en 18/25 microorganismos. Las proporciones de afecciones en la salud bucodental encontradas en las pacientes como caries (96%), gingivitis (67%), halitosis (78%) y xerostomía (56%), indican la no exclusión y superposición de las mismas, pudiendo presentarse patologías combinadas en un mismo paciente, haciendo necesario explorar de qué manera los niveles de pH y la diversidad microbiótica oral encontrados se interrelacionan, y a su vez como estas nosologías podrían tener determinantes similares.
Higienización y eliminación fúngica en instalaciones industriales para la disminución de riesgos ocupacionales
Authors: Agüero Corzo Eucaris del Carmen , Dávila Morán Roberto Carlos , Velarde Dávila Leonardo , Tinoco Plasencia Christian Jairo , Portillo Rios Héctor , Ruiz Nizama José Leonor
Published: January 2022

Se ha comprobado que la exposición a bioaerosoles se asocia con varios efectos sobre la salud, como enfermedades pulmonares y alergias. El presente estudio transversal tuvo como objetivo investigar la contaminación por hongos en varias superficies pertenecientes a dos industrias de alimentos. La toma de muestra se realizó en tres semanales, inmediatamente después de realizada la limpieza y desinfección y antes de iniciar la producción. Se recolectaron 400 muestras de superficie (vidrio, acero inoxidable, aluminio, goma y plástico), también se evaluó la eficacia del programa de higienización en el control de la población de hongos. Todas las muestras presentaron recuentos fúngicos <10 ufc/cm2, sin haber diferencias significativas entre los tipos de superficie, sin embargo, las superficies plásticas exhibieron mayor crecimiento logarítmico de los hongos. Se determinó que 49,60% de las especies identificadas correspondieron al género Penicillium. Aunque los niveles de hongos en las industrias estudiadas fueron inferiores a los niveles recomendados por la Organización Mundial de la Salud, algunas medidas de salud ambiental como lavar y desinfectar las superficies después de cada turno de trabajo, y se recomiendan inspecciones periódicas para garantizar la seguridad de los trabajadores y de los productos que allí se manufacturan
A propósito de algunos fármacos que han sido propuestos contra el nuevo coronavirus
Authors: Méndez-Hernández Jorge Camillo , Bandera-Barros Juan José , Wilches-Visbal Jorge Homero
Published: January 2022

La pandemia por COVID-19, derivada del contagio del SARS-CoV2, se ha propagado a escala global debido a su alta contagiosidad. Para contrarrestar sus efectos negativos se han ejecutado diversas medidas de prevención. No obstante, una vez que el individuo se ha infectado, resultan inútiles, debiendo procurarse tratamiento. El inicio de programas de vacunación ha traído esperanza en la lucha contra la enfermedad. Sin embargo, la OMS ha advertido que es prematuro hablar del fin de la enfermedad. sumado a ello existen, por un lado, voces disonantes sobre el papel de la vacunación en salud y, por otro, confusión sobre la efectividad, idoneidad e integridad científica sobre el uso de medicamentos para tratar la COVID-19. Vale la pena seguir explorando medicamentos para paliar los efectos de la COVID-19 dado que no existe plena seguridad de que la vacunación vaya a erradicarla en particular debido al surgimiento de nuevas cepas más agresivas o resistentes.
Enfermedades desantendidas durante la pandemia del SARS-CoV-2
Authors: Huaman-Huamancha Ebelyn , Rivera-Lozada Oriana
Published: January 2022

El 16 de marzo del 2020 se decretó en el Perú la cuarentena oficial, debido a la llegada de la pandemia de la COVID-19. Esto generó muchas repercusiones en la sociedad y sobretodo en el sector salud, donde se dejó de atender e intervenir los problemas de salud que padecen millones de peruanos. Esto debe ser evaluado, ya que, actualmente existe una gran cantidad de pacientes desatendidos, pues sus enfermedades fueron consideradas como no prioritarias en el contexto de la emergencia sanitaria por SARS-CoV-2. Por ejemplo, las enfermedades crónicas más frecuentes en nuestro medio fueron las más afectadas; dentro de ellas la diabetes, la cual ha sido reportada en el Perú como una de las enfermedades crónicas no transmisibles más importante y que actualmente se ha reportado que ha ido en continuo crecimiento, teniendo una tendencia al alza en los últimos años.
Digital: os pequenos negócios e o mundo digital
Authors:   Fundação Dom Cabral, Alberto Arruda de Oliveira Carlos , Regina Guimarães de Menezes Heloísa ,   Fundação Dom Cabral
Published: January 2022

O livro traz alguns casos e várias análises sobre o uso de ferramentas e estratégias empresariais de aplicação de tecnologias digitais nos pequenos negócios, inseridos ou não em cadeias de valor de grandes empresas ou em plataformas digitais, e incorpora visões sobre o necessário acesso aos meios digitais, o desenvolvimento de competências e de estratégias empresariais, bem como de políticas de apoio aos pequenos negócios, disponibilizando as condições adequadas e diferenciadas para a melhor inserção competitiva dessas empresas na era digital.
A lelkiismeret fogalma az ortodox etikában
Authors: Papp Miklós
Published: January 2022

The idea of conscience is a key concept in both Western and Eastern theologies. Beyond fundamental similarities in content, the specific accents in Eastern Orthodox theology are also worth considering. Here, the phenomenon of conscience is never simply treated as an ethical, philosophical or psychological entity, but the patristic, liturgical and spiritual dimensions are also an essential part of the discussion, which is in this manner always theonomous. Instead of a law-centered approach, Orthodox theology is personalistic and liturgical: conscience is the sanctuary of an encounter with God. It is God’s gift, yet it needs training within an ecclesial setting with the help of prayer, the theology of the fathers, Christian ascetic practices, the affective ethics of the liturgy, the contemplation of icons and the recital of Church hymns.
Manusia dalam Perspektif Al-Qur’an dan Psikologi
Authors: Asma Fery Rahmawan
Published: January 2022

Humans are the best creatures created by Allah SWT (ahsani taqwim). Allah honors it with various virtues as a basis for the process of becoming Allah's caliph on this earth. Therefore, humans must really realize who they are, what their essence is and what their role is in society that leads to their knowledge of the greatness of the Essence of Allah. Thus, this paper examines humans from a religious philosophical perspective around how the Qur'an views humans, the phases of their creation, the positive and negative sides of humans, as well as psychologists' views on humans and their growth and development.
教育的新希望
Authors: 吳清山 吳清山
Published: January 2022

本書運用庶民語言，淺顯易懂，期盼引起教育人員和家長們的共鳴。內容分為卷首、教育價值篇、教育芬芳篇、教育維新篇、教育希望篇和卷尾等六部分。首先就教育價值篇而言：闡析教育價值的意義，並提供一些教育政策或實例，說明教育價值之追求。其次就教育芬芳篇來看：列舉教育或社會芬芳事蹟，可供典範學習。接著就教育維新篇觀之：詮釋資訊科技及新冠疫情對教育發展影響，帶動教育革新與創新。最後就教育希望篇來說：前瞻未來教育的理念與作為，充滿著新的希望，特別提到面向2050年教育，以供參考。

作者簡介
吳清山

現職：臺北市立大學教育行政與評鑑研究所教授‧俄羅斯教育科學院海外院士

經歷：教育部國民及學前教育署署長‧教育部參事‧國家教育研究院院長‧臺北市政府教育局局長‧財團法人高等教育評鑑中心基金會執行長‧臺北市立師範學院校長‧美國紐約州立大學水牛城校區訪問學者

學歷：國立高雄師範大學教育學士‧國立政治大學教育碩士、博士
Ambiente e Salute News n.11 - settembre-ottobre 2021
Authors: Panza Costantino
Published: January 2022

Less is more: measuring body temperature during well child visits is not good for the child A recent retrospective study found the risk of prescribing unnecessary tests and therapies to the child in case of routine fever measurement during the well child visit. The article of the month discusses the need to offer clinical pathways based on evidence-based medicine.
Editorial Foreword
Authors: Leon Crina
Published: January 2022

Most of the contributions gathered in Volume 7, issue no. 2 (2015) of Revista Română pentru Studii Baltice şi Nordice / The Romanian Journal for Baltic and Nordic Studies (RRSBN) were presented at the Sixth International Conference on Baltic and Nordic Studies in Romania held on 22-23 May 2015 and entitled Historical memory, the politics of memory and cultural identity: Romania, Scandinavia and the Baltic Sea Region in comparison.
The conference was organized by the Romanian Association for Baltic and Nordic Studies in cooperation with the International Summer School of the University of Oslo, Norway and the Faculty of History and Political Sciences of Ovidius University of Constanţa, Romania and in partnership with Nordic and Baltic embassies and consulates in Romania. The conference was funded by EEA and Norway Grants 2009-2014 within the Fund for Bilateral Relations at the National Level.
The aim of the conference was to investigate the link between identity, collective memory and history in the above-mentioned areas by trying to find encounters between them and by making comparisons between the memories of the Romanian, Nordic and Baltic nations.
Reading the facades. Architexture of Kaliningrad city
Authors: Siegień Paulina
Published: January 2022

The article presents the analysis of the city space of Kaliningrad, the capital city of the Russian exclave Kaliningrad Oblast. I use the methodology proposed by Ewa Rewers – hermeneutics of a trace, and Karl Schlӧgel – new optics to analyse architectural image of Kaliningrad. The historical and architectural layers of the city coexist and have impact on the identity of its inhabitants.
The Varangian guard and its contribution to the manifestation of the imperial power in Byzantium
Authors: Airinei Alexandra
Published: January 2022

The idea that motivated the writing of this article was to treat an aspect not only of the Byzantine military history, but also of the long lasting impression that this millenary empire has left on the Northern “barbarians”, as they are often called in the Orthodox medieval sources. Its central concept is, as the title already suggests it, the imperial ideology of power, but from another perspective: the contribution of the feared Scandinavian warriors to its outlining in the Byzantine public life, as opposed to the emperor’s private existence, always hidden from the eyes of his subjects. Also, I have tried to summarise a fragment of the Norse perception on Byzantium and in what manner it influenced the former participants at the Byzantine military campaigns when they returned home.
The paper has two main directions: first of all, the one that analyses the role of the Varangian guard in the life of the Basileus and their function in the display of his divine power. Secondly, the way in which the Scandinavian mercenaries perceived their military service and their proximity to the one considered imago Dei. Furthermore, this approach is preceded by a short history of the Varangian guard and its unique type of organisation inside the Byzantine army, as well as a short description of the Norse-Byzantine relations before the founding of this special unit.
Between truth and memory: images in Lithuanian historical documentaries in post-communist transformation period
Authors: Šermukšnytė Rūta
Published: January 2022

The goal of this paper is to reveal how and why the circulation of the same historical images takes place; whose values and, simultaneously, memory are conveyed through these images; what is the relationship between the audiovisual representation of the past and collective memory? The article states that manifestations of the visual stereotypes of Lithuania history in post-communist transformation period (1988–2004) are mainly based on certain cinematic tendencies. Historical films that are considered to be an adaptation of the national narrative cinematography have been predominant since 1988. This kind of narration is characterized by validation of history as a national value, formation of national identity and its stabilization rather than diversification and correction of the collective memory or the development of critical thinking. The current documentary material that is based on the understanding of history as a myth of the nation’s history is not aimed at creating a new visual and verbal narration about the realities of the past, but rather at recognizing what has been said and made in the previous works.
Social security for Lithuanian citizens in Latvia in 1919-1939
Authors: Bukelevičiūtė Dalia
Published: January 2022

After the First World War tens of thousands of Lithuanian citizens lived in Latvia. Men have died in the war, but in Latvia lived their wives, children, parents and grandparents. As well every year about ten thousand Lithuanian citizens went to look for job in Latvia (especially temporary). Lithuanian citizens that lived in Latvia and Lithuanian citizens that came in Latvia needed to ensure social protection. These citizens were faced with a variety of social problems that had to be solved: lack of food, disease, left homeless children and etc. In 1924 Lithuania and Latvia have signed the Convention on social assistance. On the basis of this agreement social support was provided for Lithuanians in Latvia. Meanwhile, the citizens of Latvia in Lithuania did not settled large social problems and this Convention had been rarely applied to them. The Lithuanian diplomatic mission and various public organizations took care to ensure social security in Latvia for Lithuanians. According archival documents Lithuania spent the largest sum of money on social protection for its citizens in Latvia of all the European countries.