bluuebunny/crossref_metadata_2025 huggingface dataset:
SUSTAINABILITY AWARENESS IN ESP
Authors:   Academy of Applied Studies Belgrade, Novi Beograd, Serbia, Kesić Smiljka , Lipovšek Emilija
Published: July 2024

Content and Language Integrated Learning (CLIL) is applied in the English for Specific Purposes (ESP) classrooms to develop students’ linguistic competence. The core of CLIL lessons is a selected topic from several sources (websites, magazines, video materials). While learning about something new, ESP students also acquire language skills. Sustainable tourism education (STE) with its focus on social, cultural, and environmental impacts of tourism has been part of the curriculum at the College of Tourism in Belgrade. This paper will analyse the effectiveness of CLIL methods incorporating STE texts in teaching ESP and verify the results in students based on their answers written in the questionnaire. The main goal of the authors is to demonstrate that this approach to STE and ESP teaching can be used to raise ecological awareness in students and promote sustainability during English language courses, the extent of which is presented in the paper’s results and conclusions.
MEASURING SPA TOURISM SUSTAINABILITY AND SEASONALITY IN SERBIA: CASE STUDY OF THE SPA CENTRES
Authors:   University of Kragujevac, Faculty of Hotel Management and Tourism in Vrnjačka Banja, Vrnjačka Banja, Serbia, Veljović Sonja , Vasović Nevena
Published: July 2024

Nowadays, we are witnessing the ever-growing popularity of spa centres of which there are more than fifty active spas with thermal mineral springs and different capacities for tourists in the Republic of Serbia. Seasonality has a significant impact on the profitability of these destinations, even on sustainability, which is a decisive factor for the increasing number of visitors. The focus of the paper are the most notable Serbian spa centres, i.e. Vrnjačka Banja, Sokobanja, and Banja Koviljača. The Gini index and the Lorenz curve were used to assess the seasonality and imbalance in the monthly distribution of the number of tourists' overnight stays in the mentioned destinations for the period 2019-2023 influenced by COVID-19 virus pandemic. During this period, the institutional causes changed and had a significant influence on all aspects of tourism, including the seasonality. To reduce the influence of seasonality and increase the sustainability of selected resorts, it is important to combine different types of tourism, expand the services offered, and even create links to other nearest tourist centres (e.g. mountain centres).
GREEN ECONOMY, GREEN JOBS AND ECONOMIC RESILIENCE: A MONTENEGRIN PERSPECTIVE
Authors:   Biotechnical Faculty, University of Montenegro, Podogrica, Montenegro, Spalevic Velibor , Skataric Goran ,   National Parks of Montenegro, Podgorica, Montenegro, Dudic Branislav ,   Faculty of Management, Comenius University Bratislava, Bratislava, Slovakia
Published: July 2024

This article focused on some of the aspects of Green Economy, Green Jobs and Economic Resilience in Montenegro outlining the activities, initiatives, and support programs of various institutions contributing to the advancement of the green economy in the country. Key topics discussed economic diversification, circular economy initiatives, sustainable financing, incentive measures, and the role of different sectors in achieving climate and environmental goals.
ECOLINGUISTICS AND TOURISM
Authors:   University of Kragujevac, Faculty of Hotel Management and Tourism in Vrnjačka Banja, Vrnjačka Banja, Serbia, Radovanović Aleksandra , Pešić Dragana
Published: July 2024

The increasingly rapid environmental degradation, pollution, climate change, and biodiversity loss have led to the urgent need to address these issues. A response within linguistics is the emergence of ecolinguistics. Focused on fostering environmental awareness and sustainability, ecolinguistics has much to offer. It, however, still seems to be somewhat neglected. This paper sheds light on the current state of ecolinguistics, highlighting its appropriateness for addressing tourism-related texts. After discussing the main aspects of ecolinguistics, and a brief look at some relevant contributions, it ends with a small-scale qualitative analysis of eco-relevant terms in two government documents for defining the course of tourism development in Serbia. The findings indicate a shift towards more ecologically beneficial narrative, yet with a continued focus on economic prosperity.
Institutional investors’ distraction and audit fees: The mediating effect of ESG rating disagreement
Authors: Chen Yilan , Li Yiyuan
Published: July 2024

The growing focus on sustainability and responsible corporate behaviour makes the analysis of the impact of institutional investors on audit fees extremely important to ensure the transparency and reliability of non-financial reporting in the current environment. The purpose of the study was to identify the degree of influence of institutional investors on the payment for audit services of Chinese companies based on environmental, social and governance (ESG) ratings. The study was conducted using the methods of sampling, observation, analysis, and description of statistical characteristics. The results indicate a significant relationship between institutional investor distraction and increased audit fees caused by discrepancies in ESG ratings. This highlights the critical role of investor oversight in maintaining audit quality and controlling costs. While divergent ESG ratings provide auditors with more information, thereby reducing audit workloads and fees, this effect is not sufficient to offset the overall increase in audit fees due to investor distraction. The effect is more pronounced for low-tech companies, companies with high environmental impacts, and companies with lower cash flow volatility, making them more vulnerable to increased audit scrutiny and higher fees. The various differences in ESG ratings, including environmental, social and governance aspects, serve as key mediating factors, highlighting the importance of taking these differences into account when assessing audit risk and setting fees. The results obtained in the course of the study can be used to improve the ESG rating methodology, namely to increase transparency and reduce information asymmetry in the stock market
Innovative risk management in the hotel and restaurant business: Scientific and practical aspect
Authors: Shtal Tetiana , Davydova Oksana , Sysoieva Svitlana , Logvinkov Sergii , Zhukov Vladlen
Published: July 2024

Effective risk management is essential for success in the dynamic development of the hotel and restaurant business. Amid increasing competition and market instability, there is a need to develop innovative risk management strategies. The purpose of the study is to develop and test methods for assessing and minimising risks aimed at strengthening and sustainable development of enterprises in the hotel and restaurant business. Using abstract-logical analysis and a systematic approach, the study classifies enterprises depending on the level of risk. The results of this study demonstrate a comprehensive understanding of innovative management methods in the hotel and restaurant industry. The findings indicate that enterprises from the initial cluster are less vulnerable to risks, confirming the effectiveness of cluster analysis in assessing risks in the hotel and restaurant sector. In conditions of economic and political instability, systematic analysis and risk management became important. Internal risk management strategies, including innovative methods, were successfully used to reduce potential threats to the hotel and restaurant business, considering the specifics of this industry. The development and support of a dynamic information system became a key element, facilitating effective risk management and enhancing the competitiveness of enterprises. The mentioned enterprises, remaining within the lowest level of risk, confirmed the importance of using cluster analysis for identifying and managing risks in the hotel and restaurant sector. This study introduces innovative approaches to risk management in the hotel and restaurant sphere, providing specific strategies that can be used by companies to increase resilience and adapt to market competition challenges
Beneficiation of Ovbiomu Low Grade Coal Using Froth Flotation for Industrial Applications
Authors: S. Adakole , O. O. Alabi , G. Francis
Published: July 2024

Coal flotation is a highly effective separation method utilizing the differences in surface properties of coal and gangue minerals. This research entailed the beneficiation by froth flotation of low-grade coal from Obviomu Coal Mines, Edo State, Nigeria for improvement of the fixed carbon content and calorific value for industrial application. 50 kg of coal samples were collected from five different pits and were reduced using a jaw crusher to a size of 1400 μm, pulverized to a size of 1100μm. A 500-gram sample of coal was weighed and ground in a ball mill until 100% of it passed through a 250-micrometer sieve; these steps were then repeated for sieve sizes of 180, 125, 90, and 63 micrometers, respectively. A DENVER flotation cell was charged with 500 grams of well-ground coal sample of 250 µm sieve size. The process was then repeated with sieve sizes of 180 μm, 125 μm, 90 μm, and 63 μm, in that order, the results of the froth flotation beneficiation method revealed that, the weight in mass of the concentrate at sieve sizes of 250 μm, 180 μm, 125 μm, 90 μm, and 63 μm was found to be 319.209 grams, 119.227 grams, 113.028 grams, 237.657 grams, and 141.343 grams, respectively, while the weight in mass of the tailings was found to be 180.791 grams, 380.773 grams, 386.972 grams, 262.343 grams, and 358.657 grams, respectively. The calorific values of the concentrate and tailings were measured using a CalK2 bomb calorimeter. At sieve sizes of 250 μm, 180 μm, 125 μm, 90 μm, and 63 μm, the concentrate's values were found to be 44.45 MJ/Kg, 43.84 MJ/Kg, 43.66 MJ/Kg, 46.02 MJ/Kg, and 43.48 MJ/Kg, respectively, while the calorific values of the tailings were found to be 3.13 MJ/Kg, 3.31 MJ/Kg, 0.79 MJ/Kg, 3.25 MJ/Kg, and 0.18 MJ/Kg respectively. The fixed carbon content at sieve sizes of 250 μm, 180 μm, 125 μm, 90 μm, and 63 μm was found to be 74.00%, 73.000%, 72.70%, 76.60%, and 72.40%, respectively, in the concentrate, while 5.20%, 5.50 %, 1.30%, 5.40%, and 0.30 % were found in the tailings. This information was obtained through proximate analysis of the concentrate and tailings at different sieve sizes. At 90 μm, the optimum sieve size, a rise in the fixed carbon content of the coal samples was recorded, accounting for 88.53% increase of the calorific value. The study concludes that direct froth flotation is a viable and efficient method for improving the quality of low-grade coal for industrial use.
РАЗВИТИЕ РЫНКА АРЕНДЫ ЖИЛОЙ НЕДВИЖИМОСТИ
Authors: Kаrpushko Yelenа Nikolаyevnа , Cheboltаsovа Аnаstаsiyа Аndreyevnа , Kushnаrevа Аlinа Аndreyevnа , Kuramshin Renat Khosyainovich
Published: July 2024

Вопросы обеспечения граждан доступным и благоустроенным жильем являются общенациональными задачами Российской Федерации. Разработаны и реализуются государственные программы с целью поддержки граждан для решения жилищных проблем. Реализация инвестиционно-строительных проектов, направленных на строительство объектов жилой недвижимости с последующей сдачей их в аренду по доступным ценам, будет способствовать изменению сложившейся ситуации в данном сегменте рынка жилья. Рыночный механизм аренды жилой недвижимости в Российской Федерации до конца не сформирован, кроме того есть проблемы с его развитием, которые осложняют создание его устойчивой организации. Для обеспечения в стране экономической стабильности и формирования рынка арендного жилья необходимо усовершенствовать сферу аренды. В статье рассмотрено понятие и приведена классификация недвижимого имущества, описан юридический статус арендных отношений, проблемы их развития. Особое внимание уделено рынку аренды, включая уравновешивание спроса и предложения с учетом доходов граждан, а также развитие арендных услуг посреднических предприятий на рынке недвижимости.
Hernia inguinal de contenido inusual: divertículo de Meckel. Reporte de caso
Authors: Araujo Daza Ana , Rolla Juan Bautista , Rodríguez De La Hoz Diana Marcela , Canavesi Martín , Santillán Mateo , Larrañaga Víctor Nebil
Published: July 2024

La hernia de Littre se define como la protrusión del divertículo de Meckel a través de cualquier potencial apertura de la pared abdominal. Es una complicación infrecuente (1% de los divertículos existentes), con pocos casos registrados en la literatura médica. Se presenta el caso clínico de un paciente de sexo masculino de 78 años con dolor abdominal en hipogastrio y en fosa ilíaca derecha, asociado a una formación inguinal palpable que se diagnosticó como hernia de Littre.
Impacto de los P-CABs en el tratamiento de las enfermedades relacionadas con el ácido: una revisión de la evidencia
Authors: Remes-Troche José M. , Vargas-Basurto José Luis , Valdovinos-García Luis
Published: July 2024

Los bloqueadores ácidos competitivos de potasio (P-CABs), como vonoprazan, fexuprazan, tegoprazan y revaprazan, representan una clase innovadora de medicamentos diseñados para tratar afecciones relacionadas con la secreción de ácido gástrico, incluida la enfermedad por reflujo gastroesofágico (ERGE), la infección por Helicobacter pylori (Hp) y la enfermedad ulcerosa péptica. Estos fármacos actúan inhibiendo de manera reversible y competitiva la bomba de protones H+/K+-ATPasa, lo cual les permite suprimir la producción de ácido gástrico de forma más efectiva y con una rapidez superior en comparación con los inhibidores de la bomba de protones (IBP) tradicionales. Además, estos fármacos no se ven interferidos por la enzima CYP2C19 y su efecto es independiente de la ingesta de alimentos, lo que les confiere ventajas sobre la mayoría de los IBP. Los estudios clínicos han demostrado que los P-CABs son superiores a los IBP en el manejo de la ERGE erosiva severa, y no inferiores en los grados leves y en la enfermedad no erosiva.Por otra parte, los P-CABs ofrecen tasas de erradicaciónde Hp no inferiores y, en algunos casos, superiores a las delos IBP, en los tratamientos de primera línea, pero no enlos de segunda. En conclusión, los P-CABs emergen comoalternativas prometedoras en el manejo de trastornos gastrointestinalesácido-dependientes.
Protective Effect of the QiBracelet® Against Oxidative Stress
Authors: Dartsch Peter C.
Published: July 2024

Environmental oxidative stress is caused by different artificial and natural sources (environmental stressors). These influences might increase the generation of reactive oxygen species which are known to cause unwanted adverse health effects. According to the manufacturer, the QiBracelet® contains a grid chip which forms a static field that stimulates water molecules to undergo a transition into the coherent state. Since our body consists of about 70-85 % of water, the coherent state of the water molecules should be able to influence the cells of our whole body in a positive manner. Thus, the cells might obtain the ability to compensate any environmental stressors causing oxidative stress much more efficient when compared with endogenous enzymatic systems. The goal of this study was to investigate whether different cultured cell types were able to resist exogenous oxidative stress by addition of 2 mM hydrogen peroxide to the culture medium much more efficient in the presence of the QiBracelet® in comparison to unprotected control cells. Without protection, connective tissue fibroblasts (L-929) were the most sensitive cell type, while lung cells (A-549) were the least sensitive; connective tissue fibroblasts showed a loss in viability of 24% and lung cells of 84%. The other cell types such as kidney cells (MDCK), liver cells (Hep G2) and intestinal epithelial cells (IPEC-J2) had a viability between the two values. Independent from cell type, the QiBracelet® demonstrated a protective effect against exogenous oxidative stress. The extent of this protection varied among cell types, with liver cells showing the highest level of protection at 47.3 ± 7.1 %, followed by connective tissue fibroblasts at 29.6 ± 5.6%, kidney cells at 27.1 ± 5.9%, intestinal epithelial cells at 18.0 ± 7.1%, and lung cells at only 3.9 ± 2.8%. The results demonstrate that the use of the QiBracelet® was able to protect all tested cell types from the hydrogen peroxide-induced environmental oxidative stress. Therefore, the QiBracelet® might also promote and maintain a better well-being and attitude of life in vivo.
A Rigorous Academic Inquiry: Leveraging Concept Mapping Methodologies for Amplifying Learning Efficacy in Inaugural BHMS 2 CBDC Cohorts
Authors: Zagday Avishkar
Published: July 2024

Background: The study aims to evaluate cognitive gain, student perceptions of concept mapping, compare its effectiveness versus traditional methods, and teach the use of concept mapping as a learning strategy in physiology for clinical practice. Materials and Methods: The study involved 122 students from two batches of First BHMS at CMP Homeopathic Medical College, Mumbai. They were taught concept maps, sent YouTube videos, and instructed to draw them in their A3 drawing book. Awards were given for best concept mapping book, and a survey was conducted to compare different learning methods with Concept Mapping. Results: The study reveals that concept mapping is a highly effective learning tool that significantly enhances cognitive gains among physiology students, making it a robust pedagogical strategy that can provide profound and meaningful learning experiences in the complex field of physiology education. Conclusion: The study survey highlighted how concept mapping helps CMP Homeopathic Medical College, Mumbai's First BHMS students learn more effectively. Also, idea mapping improves comprehension and academic achievement by allowing for meaningful links between concepts. The suggestion of concept mapping as an effective teaching strategy within the CBDC curriculum is supported by the favorable comments from students and the benefits that have been noted. Subsequent investigations ought to go deeper into the workings of idea mapping and examine its enduring effects on knowledge retention and application.
A Matrix Universe as the Origin of Inertia and Momentum and Translocation as a Chemical Reaction
Authors: Norman Hansen John
Published: July 2024

It is proposed that there is a matrix structure of the universe that persists both in the presence and absence of physical objects, and that chemical reactions involve reorganization of electronic orbitals within this matrix structure. The mechanism by which objects translocate within this matrix is similar to the chemical reaction mechanism, and therefore requires moving objects to cross transition-state energy barriers. This involves an input of energy, which is the origin of inertia and momentum. The matrix concept is used to derive equations of motion that conform to Newton’s laws and include terms for inertia and momentum.
NEUROMARKETING: NAVIGATING NEW PERSPECTIVES IN NEUROSCIENCE AND MARKETING SYNTHESIS
Authors: Akan Şahap , Atalık Özlem
Published: July 2024

In recent years, the field of neuromarketing has attracted considerable attention from both academics and practitioners. Neuromarketing differs from other fields in terms of both the tools and methods used in market research. Therefore, there is a need for literature reviews that focus on studies conducted in this field to acquire insights into the work carried out. This study aims to fill this gap by evaluating the techniques used in neuromarketing studies within the existing literature and presenting research findings to provide researchers a framework for these investigations. Neuromarketing studies, reviewed under headings such as EEG, fMRI, and others, have been explained in detail in terms of research tools, samples, research topics, and findings. In addition, the research approaches and applications adopted in these pertinent studies have been meticulously addressed. Ultimately, this research aims to provide a more comprehensive approach to the current state of neuromarketing studies, thereby contributing to the development of this interdisciplinary field. Additionally, it highlights future research directions in terms of theory, application, and methodology.
Reliability and Validity of the Turkish Version of the Adolescent Sexual and Reproductive Competency Assessment Tool
Authors: Dinç Fatma , Kurt Aylin , Pekyiğit Aylin
Published: July 2024

Objective: The purpose of the current study is to undertake the Turkish adaptation of the Adolescent Sexual and Reproductive Competency Assessment Tool and assess its validity and reliability. Materials and Methods: This research adopts a methodological approach. Between August and December, we engaged with 402 nurses and doctors working in two state hospitals. Data were collected using the “Descriptive Characteristics Form” and the “Adolescent Sexual and Reproductive Competency Assessment Tool.” Analysis and evaluation involved factor analysis, Cronbach’s alpha analysis, item-total score correlation analysis, content validity, construct validity, and concurrent validity. Results: Adolescent Sexual and Reproductive Competency Assessment Tool demonstrated high internal consistency (Cronbach’s alpha=0.859). The item-total correlation values ranged from 0.491 to 0.789. Adolescent Sexual and Reproductive Competency Assessment Tool exhibited a four-factor structure, explaining 64% of the total variance in the measured variables. Conclusion: The Turkish version of Adolescent Sexual and Reproductive Competency Assessment Tool exhibited high validity and reliability within the Turkish population. We suggest that healthcare professionals utilize it to evaluate competency skills related to the management and decision-making in adolescent sexual and reproductive health.
Filosofía y ciencias humanas según Francisco Leocata
Authors: Hoevel Carlos
Published: July 2024

Este artículo traza los grandes rasgos de la propuesta para el diálogo interdisciplinar entre la filosofía y las ciencias humanas en el pensamiento del filósofo argentino Francisco Leocata. El autor parte de la descripción y la crítica que realiza Leocata al programa positivista y neopositivista que intenta reducir las ciencias humanas a los cánones metodológicos de las ciencias naturales. Luego señala los problemas que ve Leocata en las propuestas de interdisciplinariedad de carácter ecléctico, post-estructuralista y utópico-crítico. Asimismo, el autor describe el punto de vista de Leocata acerca de las posibilidades positivas de la racionalidad hermenéutica señalando, al mismo tiempo, los riesgos que puede implicar una adopción desmesurada de este tipo de racionalidad. Finalmente, el autor argumenta que el camino adoptado por Leocata para hacer posible este diálogo interdisciplinar va principalmente en la línea de una visión renovada de la fenomenología de Husserl, de la Antropología filosófica y de la Psicología científica.
El problema cronológico de la caída angélica en Tomás de Aquino
Authors: Jakubecki Natalia
Published: July 2024

Al pensar su demonio, Tomás de Aquino aplica una serie de correctivos respecto de la tradición agustiniana con la intención tácita de alejar a los ángeles –y, por tanto, a los demonios– de la concepción antropologizante que había predominado en el milenio anterior. Pero en el mismo intento de alejar al ángel del ser humano, el Aquinate le confiere un peso ontológico que, por momentos, lo acerca peligrosamente a Dios. De todas las consecuencias que de ello se derivan, nos interesa aquí, particularmente, la cadena de implicaciones de una de ellas: tanto desde el punto de vista metafísico, como desde el gnoseológico, las perfecciones angélicas resultan problemáticas al momento de confrontarlas con el factum de la Caída. Así pues, en este trabajo nos proponemos problematizar los fundamentos teológicos y filosóficos de la cronología del drama angélico formulada por Tomás. De manera que, en un primer momento, repararemos en algunas de las peculiares características de las naturalezas angélicas; luego, estaremos en condiciones de señalar cuáles son los principales problemas que se suscitan al interior de su angelología en relación con el instante de la Caída para, finalmente, encontrar las soluciones que se desprenden de la obra del Aquinate.
La cogitativa en Cornelio Fabro. Para una filosofía no dualista de la percepción
Authors: Sanguineti Juan José
Published: July 2024

Este trabajo considera la relevancia de la teoría de la potencia de la cogitativa de Tomás de Aquino, subrayada por Cornelio Fabro durante sus primeras investigaciones en los años 40 del siglo XX, en los actuales estudios neuropsicológicos, y en especial como un modo especial de superar una perspectiva dualista en la psicología de la percepción. La tesis es coherente con una visión antropológica basada en la unidad substancial entre alma y cuerpo. En consecuencia, las capacidades de la facultad de la cogitativa (estimativa, en los animales) implican una peculiar versión de la percepción, irreductible a puro pensamiento, así como a las sensaciones, una versión que está presente en la concepción psicológica de M. Merleau-Ponty y de J. J. Gibson.
Recensión: Domenico Tubito, La multiforme grazia di Dio: Attualità della sintesi tommasiana nella Summa Theologiae
Authors: Sequeira Joshua Alexander
Published: July 2024

Domenico Tubito, La multiforme grazia di Dio: Attualità della sintesi tommasiana nella Summa Theologiae, Napoli, Editrice Domenicana Italiana, 2013, 288 pp.
Exploring the Relationship between SLC30A8 Gene Polymorphism and Type 2 Diabetes Susceptibility in District Vehari, Pakistan
Authors: Fatima Ghafoor  , Samreen Riaz
Published: July 2024

Type 2 diabetes mellitus (T2DM) is estimated to afflict 537 million individuals globally and has reached an epidemic scale. These global estimates are to develop innovative preventive and treatment methods and to put these methods into action. To investigate if SLC30A8 gene polymorphisms can be used to predict the onset of T2DM in residents of Punjab, Pakistan, two groups were established based on prospective follow-up of appropriate population samples. Males made up 29.6% and women 70.4% of the T2DM unit. Deoxyribonucleic acid (DNA) was separated. Polymerase chain reaction or PCR was used for genotyping, and real-time PCR was then conducted. The statistical analysis was performed utilizing the statistical package SPSS 16.0 software program. The SLC30A8 gene genotype TT rs13266634 was linked to an increased risk of type 2 diabetes mellitus (T2DM) (relative risk — RR 1.51, 95% confidence interval — CI 1.11 – 2.05, p = 0.008). A protective benefit against T2DM was linked to the SLC30A8 gene's CC genotype, rs13266634 (RR 0.57, 95% CI 0.35 – 0.92, p = 0.026). The T2DM group comprised 442 individuals in the District Vehari. The average age at the time of the initial screening was 56.2 ± 6.7 years. 531 individuals without diabetes were chosen to serve as controls; their average age was 56.1 ± 7.1 years. In the control group, the frequencies of single nucleotide polymorphisms (abbreviated as SNP) match the expected frequencies as per the Hardy–Weinberg equilibrium. The SLC30A8 gene's rs13266634 polymorphism shows its correlation with the likelihood of developing T2DM and can be a potential candidate for a diabetes risk score.
BİR MİKRO TARİH ÇALIŞMASI OLARAK ŞANLIURFA TARİHİNİ YABANCI SEYYAHLARIN ESERLERİNDEN OKUMAK
Authors: Deveci Bozkuş Yıldız
Published: July 2024

Bu çalışmada, mikro tarih araştırmalarından hareketle XVIII. ve XIX. yüzyılda Urfa’ya gelmiş veya bu güzergahtan geçmiş İngiliz ve Alman seyyahların eserleri incelenmiştir. Çalışmanın kapsamında, Batılı seyyahların Osmanlı kentlerine geliş nedenleri, kaleme aldıkları seyahatnameler ve bu eserlerin tarihten günümüze dünyada Türk imajının oluşumu ile Türkiye ile ilişkilerin şekillenmesinde ne tür etkileri olduğuna odaklanılmıştır. Bu çerçevede eserlerin tasnifinde özellikle Urfa’ya dair bölümlerin yer aldığı ve ağırlıklı olarak armchair traveler olmayan seyyahların eserleri incelenmiştir. Bu eserlerde seyyahların Urfa’nın tarihi ve stratejik önemini nasıl ele aldıkları, bölgedeki demografik yapı, etnik ve dini grupların seyyahlarla olan ilişkileri ve kentin sosyo-kültürel özelliğine odaklanılmıştır. Ayrıca bölgeye dair raporlar hazırlayan Batılı seyyahların söz konusu eserlerinin ne kadar objektif olduğu da oryantalizm perspektifinden ortaya konmaya çalışılmıştır. Bu çerçevede mikro tarih araştırmalarıyla batılı yabancı seyyahların büyük tarihî dönemleri ve olayları seyahatnamelerinde nasıl tasvir ettiğine bakılarak bölgedeki toplumsal ve kültürel değişimin izleri ortaya konmuş ve incelenmiştir.
Análisis de las elasticidades de la recaudación tributaria en El Salvador
Authors: Rodríguez Balmore Alexis
Published: July 2024

El presente documento tiene como objetivo general cuantificar la elasticidad del Producto Interno Bruto (PIB) en relación a la estructura tributaria de la economía salvadoreña. Para dar cumplir con el objetivo general se plantearon dos ejercicios econométricos: en primer se calculó la elasticidad del Producto Interno Bruto en relación al Impuesto al Valor Agregado al Impuesto Sobre la Renta (ISR) que son los más importantes dentro de la estructura tributaria; en según lugar, se determinó la elasticidad de los ingresos tributarios en relación a los sectores económicos (agrícola, industria y servicios).
Periferias na pandemia: um olhar a partir da (in)segurança humana
Authors: Tomesani Ana Maura , Maschietto Roberta Holanda , Braga Camila Macedo , Ricarte Joana
Published: July 2024

Este trabalho analisa a experiência de diferentes populações periféricas durante a pandemia de Covid-19 a partir de seus relatos. Nosso olhar parte de uma perspectiva crítica sobre a (in)segurança humana no Brasil que atinge de forma distinta grupos mais vulneráveis, reforçando problemas de dimensão estrutural que antecedem a pandemia. A partir da análise temática de 40 testemunhos, identificamos quais dimensões de (in)segurança humana são preponderantes e como se relacionam não apenas entre si, mas também com aspectos estruturais e históricos da sociedade brasileira. Os testemunhos analisados incluem textos, áudios e vídeos submetidos ao repositório do projeto Periferias na Pandemia, desenvolvido a partir de uma parceria entre o Centro de Estudos em Conflito e Paz (NUPRI/USP) e a Fundação Perseu Abramo. Foram recebidos entre abril de 2022 e abril de 2023 a partir de localidades de 21 unidades federativas e tratam não apenas das experiências pessoais desses indivíduos, como também das respostas e ausências do Estado em suas comunidades, além de processos de mobilização social para responder aos desafios oriundos da pandemia. Nosso argumento é que uma visão periférica sobre a segurança humana no Brasil neste período pandêmico pode contribuir para se pensar medidas mais efetivas para a redução de danos em situações emergenciais – como epidemias ou catástrofes naturais - e para a formulação de agendas políticas mais alinhadas com a pluralidade das periferias brasileiras.
Engaging and involving clients in open note-taking practices in narrative therapy
Authors: Coulthard Jamie
Published: July 2024

PHOTO CREDIT: Jamie Coulthard

Narrative therapists empower others, both in relation to dominant negative stories that are told about their lives, and within the therapeutic relationship itself. They try to correct the inevitable power imbalance between therapist and client by adopting a ‘decentred’ stance, eschewing technical jargon, and by using idiosyncratic externalised language. This article proposes that the way in which we take notes matters for these power-relationships. By asking permission, writing notes openly, and engaging clients in their co-production, we resist disempowering them by appropriating their personal information. Moreover, these practices support externalisation, open creative possibilities, and invite new perspectives on therapeutic work.
DESIGN, FORMULATION AND EVALUATION OF PIROXICAM TABLETS USING ARTIFICIAL NEURAL NETWORK
Authors: Akki Pratiksha ,   Department of Pharmaceutics, KLE College of Pharmacy, Hubballi-580 031, Karnataka, India, V. Apoorva , Akki Kusum S. ,   Department of Pharmaceutics, KLE College of Pharmacy, Hubballi-580 031, Karnataka, India,   Department of Pharmacognosy, KLE College of Pharmacy, Hubballi-580 031, Karnataka, India
Published: July 2024

In the realm of pharmaceuticals, artificial intelligence (AI) denotes the application of automated algorithms to tasks traditionally associated with human cognitive abilities. An artificial neural network (ANN) serves as a simulation of the human brain, aiming to replicate both the structure and functionality of genuine neurons. Oral disintegrating tablets (ODTs), which can dissolve on the tongue in three minutes or less, are an unusual dosage form, particularly concerning the elderly and young patients. Formulation studies of ODTs face challenges, as they often depend on conventional laboratory trial-and-error methods and the expertise of pharmaceutical professionals. Unfortunately, this approach proves inefficient and timeconsuming. The primary focus of the present research was to create an artificial neural network (ANN) prediction model tailored for ODT formulations employing the wet granulation technique. A literature review was carried out by collecting 307 formulation data set to train the data. For the ODT formulation, the ANN predicted and practically obtained values were compared. Formulations were subjected to pre-compression and post-compression parameters due to oral disintegration; the focus was on assessment of disintegration period and rate of in vitro dissolution. Notably, in the case of the PF7 formulation, the predicted disintegration time was precisely 48.476 seconds, closely aligning with the obtained result of 45.1 seconds. Additionally, the in vitro dissolution rate was accurately predicted at 92.34%, with the actual result being 93.74%. Besides, this dissolution rate stands out as the highest among all the formulations examined. Experimental data revealed, the almost identical estimate for ODT formulations compared to the ANN prediction. The application of this prediction model could efficiently reduce the time and cost required to produce a pharmaceutical and consequently facilitate the advancement of a potent drug product.
IN SILICO DESIGNING AND SCREENING OF CARBAZOLE DERIVATIVES AS TOPOISOMERASE II INHIBITORS
Authors: Jose Elseena ,   Department of Pharmaceutical Chemistry, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam-686 661, Kerala, India, Francis Prasanth , Joy Mariya , Joseph Shilpa , Sukumaran Sunitha , Baby Sini , Baby Sini ,   Department of Pharmaceutical Chemistry, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam-686 661, Kerala, India,   Department of Pharmaceutical Chemistry, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam-686 661, Kerala, India,   Department of Pharmaceutical Chemistry, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam-686 661, Kerala, India,   Department of Pharmaceutical Chemistry, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam-686 661, Kerala, India,   Department of Pharmaceutical Chemistry, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam-686 661, Kerala, India
Published: July 2024

Due to side effects and drug resistance, cancer treatment choices are limited despite continued attempts. Topoisomerases are essential for several cellular processes and human topoisomerase I and topoisomerase II alpha inhibitors have proven to be an effective chemotherapeutic alternative for a wide range of cancers, due to its fast proliferating cells and the higher level of these enzymes in solid tumors relative to normal tissue. In this study, around 30 carbazole derivatives were designed using Chem Draw ultra and their ability to inhibit topoisomerase II was investigated using in silico docking studies and molecular dynamics. The results revealed ligand 10 and ligand 25 held good binding energy scores of -9.21 and -9.50, Kcal mol-1 respectively, with good interaction. ADMET analysis assured the drug likeness and better GI absorption than the parent drug and dexrazoxane. Desmond module of Schrödinger Suite was used and it demonstrated the stability in ligand receptor complexes.
DEVELOPMENT AND EVALUATION OF PHARMACEUTICALLY EQUIVALENT LEVOSALBUTAMOL DRY POWDER INHALER WITH INCREASED IN VITRO DEPOSITION
Authors: Dongare Suraj L. ,   Department of Pharmaceutics, SMBT College of Pharmacy, Dhamangaon - 422 403, Nashik, Maharashtra, India, Narkhede Minal R. , Rathod Prachiti S. ,   Department of Pharmaceutics, SMBT College of Pharmacy, Dhamangaon - 422 403, Nashik, Maharashtra, India,   Department of Pharmaceutics, SMBT College of Pharmacy, Dhamangaon - 422 403, Nashik, Maharashtra, India
Published: July 2024

The advancement and assessment of an efficient and safe dry powder inhaler formulation for levosalbutamol are critical for optimizing its therapeutic potential in managing chronic obstructive pulmonary disease (COPD). This study aims to provide an overview of the development process and evaluation outcomes of a levosalbutamol dry powder inhaler, including formulation development, physicochemical characterization and in vitro performance assessment. It employed a stepwise approach to develop and evaluate the inhaler. Initially, different excipients (Respitose®SV010, Respitose®ML006, Respitose®SV003, Lactohale LH100, Lactohale LH300) and particle size distributions were evaluated to optimize the formulation. Physicochemical characterization, such as particle size, shape and density were conducted using appropriate techniques. In vitro performance assessments, together with fine particle fractions, emitted dose and aerodynamic particle size distribution was determined using validated methods. The formulation development process resulted in an optimized levosalbutamol dry powder inhaler with desirable physicochemical properties, including uniform particle size distribution and suitable density for effective inhalation. In vitro assessments demonstrated favourable aerodynamic characteristics, with a high emitted dose and significant fine particle fraction, indicating efficient lung deposition and therapeutic efficacy. These findings support the potential of the levosalbutamol dry powder inhaler as an effective treatment option for respiratory conditions such as asthma and COPD.
INTEGRATIVE ANALYSIS OF MORINGA OLEIFERA PHYTOCHEMICAL COMPOSITION: INSIGHTS FROM LCMS/MS, HPTLC, HPLC PROFILING AND MOLECULAR DOCKING STUDIES
Authors: Nehere Shital ,   School of Biosciences and Bioengineering, D. Y. Patil International University, Sector 29, Nigdi Pradhikaran, Akurdi, Pune-411 044, Maharashtra, India, Bhise Kiran ,   School of Biosciences and Bioengineering, D. Y. Patil International University, Sector 29, Nigdi Pradhikaran, Akurdi, Pune-411 044, Maharashtra, India
Published: July 2024

This research presents a comprehensive investigation into the phytochemical composition of Moringa oleifera utilizing LCMS/MS, HPTLC, HPLC profiling and molecular docking studies. LCMS/MS analysis identified 10 key phytocompounds, including β-carbolines, octadecadiynoic acid and quercetin. HPLC technique quantified the presence of quercetin and kaempferol, gallic acid and caffeic acid. Molecular docking studies, conducted using CBDock2, unveiled potential interactions between these compounds and specific target proteins, such as β-glucosidase (PDB ID: 2ZOX). The docking results indicated favourable binding affinities for quercetin-3-O-glucoside, quercetin and kaempferol, highlighting their potential bioactivity.
Efforts to Prevent Early Marriage with Counseling Psychology Services in Srengat District, Blitar Regency
Authors: Hendra Pradana Hengki , Suwatin Wiwik , Ridwan Fauzen M. Nur
Published: July 2024

The aim of this research is to identify the factors influencing early marriage in Srengat District, Blitar Regency. The method employed is descriptive with a qualitative approach, gathering data directly from the research subjects through observation, interviews, and documentation. Data analysis involves data reduction, data presentation, and conclusion drawing or verification techniques. The study subjects include 2 individuals for interviews and young villagers aged 15-20 years for pretest and posttest assessments, totaling 50 respondents. The research findings indicate that common factors driving early marriages in our society include economic circumstances, education, parental influence, and mass media. The pretest score was 35.7333 and the posttest score was 71.0000, showing an improvement of 35.2667. Additionally, these results demonstrate a significance level of < 0.05, indicating a statistically significant increase in the activity's outcome scores.
Lessons learned from chemoprophylaxis programmes for neglected diseases and diseases of poverty in Latin America: a systematic review
Authors: Cordeiro Wilcare de Medeiros , Rocha Aymée Medeiros da , Silva Taynara Lais , Bandeira Mary Anne Medeiros , Arrais Paulo Sergio Dourado
Published: July 2024

It is estimated that over a billion people globally are affected by neglected tropical diseases, mainly in developing countries. This systematic review examines the scope, effectiveness, and challenges of chemoprophylaxis programs targeting lymphatic filariasis, leprosy, onchocerciasis, schistosomiasis, soil-transmitted helminths, and tuberculosis in Latin America. The aim is to evaluate the implementation and outcomes of these programs by analyzing studies published from January 2000 to March 2023. A comprehensive search was conducted across six electronic databases, resulting in 66 relevant studies from an initial pool of 2481 records. These studies, originating from thirteen countries, were assessed using the PRISMA guidelines. The results indicate that chemoprophylaxis programs, particularly those led by local healthcare professionals, have significantly reduced infectious disease prevalence and transmission rates in endemic regions. The effectiveness of these programs is influenced by several factors, including the length of regimen, patient adherence, and community engagement. In order to increase participation and ensure program success, educational strategies and adopting more localized approaches are essential. However, challenges remain, particularly in remote areas and regions with high migration rates, such as the Amazon. While the review highlights the potential of chemoprophylaxis in improving public health outcomes, it also underscores the need for more extensive cost-effectiveness studies to assess the financial viability of these interventions. The evidence supports the continued optimization of chemoprophylaxis programs, emphasizing the importance of sustained, community-centered approaches. Ongoing research and improvement are critical to overcoming current obstacles and enhancing global efforts to control and eradicate these diseases.
Eficiência agronômica da Jitirana como adubo orgânico no consórcio de hortelã com rúcula
Authors: Melo Wyara Ferreira , Linhares Paulo César Ferreira , Nascimento José Wallace Barbosa do , Lima Antonio Gilson Barbosa de , Formiga José Alves , Rolim Fagno Dallino , Freires Maria Amanda Laurentino , Medeiros Aline Carla de , Maracajá Patrício Borges
Published: July 2024

O cultivo de diversas plantas em sistema de consórcio constitui em alternativa viável para os agricultores familiares. Nesse sentido, o estudo objetiva estudar a eficiência agronômica da jitirana como adubo orgânico no consórcio de hortelã com rúcula. Metodologicamente, a pesquisa trata-se de um estudo experimental, conduzido na Fazenda Experimental Rafael Fernandes, no distrito de Alagoinha, zona rural de Mossoró-RN. O delineamento experimental de blocos completos casualizados com os tratamentos arranjados em esquema fatorial 2 x 4, com três repetições. O primeiro fator foi constituído do cultivo solteiro e consorciado da hortelã e da rúcula, e o segundo fator constituído das diferentes quantidades de jitirana (0,0; 1,0; 2,0 e 3,0 kg m-2 de canteiro). Para a cultura da hortelã utilizou-se a cultivar “Mentha piperita”. Para a cultura da rúcula utilizou-se a cultivar “Cultivada”. As características avaliadas para a cultura da hortelã foram as seguintes: altura da biomassa, massa fresca, número de molhos, massa seca, teor e rendimento de óleo. As características avaliadas para a rúcula foram: altura e número de folhas por planta, rendimento, número de molhos e massa seca da rúcula. O melhor desempenho agronômico do sistema foi obtido na quantidade de 3,0 kg m-2 de jitirana. O consórcio apresentou razão de área equivalente superior a 1,0, com valor médio de 1,37 na quantidade de 3,0 kg m de jitirana incorporado ao solo. Houve um melhor aproveitamento dos recursos disponíveis (água, adubo, solo e luz), sem comprometer a qualidade comercial da hortelã e rúcula.
Atuação do enfermeiro na prevenção de acidentes domésticos infantis na atenção primária à saúde
Authors: Oliveira Ana Carla de , Melo Dilene Fontinele Catunda , Albuquerque Izabelle Mont’Alverne Napoleão , Ribeiro Marcos Aguiar , Medeiros Neto Calisto Dantas de , Lima Lidiana Ximenes Sérvulo Moreira , Cavalcante Rosângela Souza , Porto Gizele Soares Martins , Andrade Matheus Gomes
Published: July 2024

Perante os acidentes domésticos infantis os enfermeiros devem atuar na redução de danos e agravos e é durante a execução da consulta de puericultura, que podem avaliar e prevenir os riscos frente ao meio em que a criança vive. Este estudo teve por objetivo avaliar a atuação do enfermeiro na prevenção de acidentes domésticos infantis na Atenção Primária à Saúde. Trata-se de uma pesquisa do tipo exploratória, descritiva e de abordagem quantitativa desenvolvida nas Unidades de Atenção Primária a Saúde em um município dos Sertões de Crateús - Ceará, que possui o total de 24 unidades de atenção primária. Este estudo obedeceu a todos os princípios da ética em pesquisas realizadas com seres humanos, sendo submetida na Plataforma Brasil, sendo autorizada pelo comitê de ética, sob Parecer Nº 77735323.9.0000.8133. O estudo demostrou que 16 (64%) profissionais enfermeiros atuantes nas unidades trabalham o tema de prevenção a acidentes domésticos infantis de forma geral em todos os atendimentos e em sua maioria utiliza a educação em saúde como estratégia. Referente à abordagem da temática durante as puericulturas, cerca de 96% (24) dos participantes relataram trabalhar sobre os acidentes domésticos infantis em todas as consultas de puericultura, e apenas 4% (1) dos profissionais nunca abordou o tema em meio as consultas voltadas ao público infantil. No questionamento relacionado ao uso do cartão de vacinação, 14 (56%) dos profissionais relataram trabalhar sobre o tema em todas as consultas de puericultura usando o cartão e apenas um (4%) nunca trabalhou a temática e 03 (12%) dos profissionais relataram não preenchem o cartão de vacinação no tópico de acidentes domésticos infantis. Diante do questionamento sobre a capacitação na temática para o profissional enfermeiro ou algum outro membro da equipe 19 (36%) dos profissionais nunca participaram ou receberam capacitações sobre o tema. Dessa forma, concluiu-se a necessidade de os profissionais enfermeiros atuarem de forma mais efetiva na prevenção de acidentes domésticos infantis, utilizando estratégias de educação em saúde e aproveitando as consultas de puericultura e em geral como oportunidades para orientar os pais e cuidadores.
Femme Fatale in French Film Noir
Authors: Gegen Gegen
Published: July 2024

The term film noir was coined by two French film critics Borde and Chaumenton in 1956 to describe American detective stories mode in the 1940s. Noir films were seen as a counter-cultural movement within Hollywood at that time, and the French new wave continued this feature in the 1960s. Therefore, the term noir itself connects the Frenchness and Americanness. This paper tends to map out the film noir sensibilities in French content through unfolding the characteristics of femme fatale in two French noir films Jean-Luc Godards A bout de souffle (Breathless) (1960) and Jean-Jacques Beineixs Diva (1981).