bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of bioactivities of the bacterial strain Bacillus velezensis B26
Authors: Ghurye Aadarsh , Joshi Shikar , Mahadev Pednekar Nikita , K. Shetty Nandini B. , Jain Akshit V. , Rahangdale Rakesh , Chandrashekhar Raghu , Volety Mallikarjuna Subrahmanyam , Kolathur Kiran Kumar
Published: November 2024

Bacillus species are widely recognized as effective biocontrol agents utilized for suppressing plant pathogens. These species isolated from diverse habitats exhibit antifungal activity against several plant pathogens. Although complete genome sequences of several Bacillus species have been reported, exploration of the bioactivities of the Bacillus velezensis strains remains limited. In this study, we aimed to assess the bioactivities exhibited by the bacterial strain B. velezensis B26. Through our screening process, we identified B. velezensis B26 as a producer of chondroitinase enzyme, additionally demonstrating chitinase, glucanase, amylase, and gelatinase activities. Significantly, we unveil the potent antifungal capabilities of the B. velezensis B26 against opportunistic fungal pathogen Candida albicans and emerging fungal pathogen Saccharomyces cerevisiae.
New soft tissue data of pterosaur tail vane reveals sophisticated, dynamic tensioning usage and expands its evolutionary origins
Authors: Jagielska Natalia , Kaye Thomas G , Habib Michael B , Hirasawa Tatsuya , Pittman Michael
Published: November 2024

Pterosaurs were the first vertebrates to achieve powered flight. Early pterosaurs had long stiff tails with a mobile base that could shift their center of mass, potentially benefiting flight control. These tails ended in a tall, thin soft tissue vane that would compromise aerodynamic control and efficiency if it fluttered excessively during flight. Maintaining stiffness in the vane would have been crucial in early pterosaur flight, but how this was achieved has been unclear, especially since vanes were lost in later pterosaurs and are absent in birds and bats. Here we use Laser-Stimulated Fluorescence imaging to reveal a cross-linking lattice within the tail vanes of early pterosaurs. The lattice supported a sophisticated dynamic tensioning system used to maintain vane stiffness, allowing the whole tail to augment flight control and the vane to function as a display structure.
The membrane domains of mammalian adenylyl cyclases are lipid receptors
Authors: Landau Marius , Elsabbagh Sherif , Gross Harald , Fuchs Adrian CD , Schultz Anita CF , Schultz Joachim E
Published: November 2024

The biosynthesis of cyclic 3′,5′-adenosine monophosphate (cAMP) by mammalian membrane-bound adenylyl cyclases (mACs) is predominantly regulated by G-protein-coupled receptors (GPCRs). Up to now the two hexahelical transmembrane domains of mACs were considered to fix the enzyme to membranes. Here, we show that the transmembrane domains serve in addition as signal receptors and transmitters of lipid signals that control Gsα-stimulated mAC activities. We identify aliphatic fatty acids and anandamide as receptor ligands of mAC isoforms 1–7 and 9. The ligands enhance (mAC isoforms 2, 3, 7, and 9) or attenuate (isoforms 1, 4, 5, and 6) Gsα-stimulated mAC activities in vitro and in vivo. Substitution of the stimulatory membrane receptor of mAC3 by the inhibitory receptor of mAC5 results in a ligand inhibited mAC5–mAC3 chimera. Thus, we discovered a new class of membrane receptors in which two signaling modalities are at a crossing, direct tonic lipid and indirect phasic GPCR–Gsα signaling regulating the biosynthesis of cAMP.
Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition
Authors: Pepin Anne-Sophie , Jazwiec Patrycja A , Dumeaux Vanessa , Sloboda Deborah M , Kimmins Sarah
Published: November 2024

Paternal obesity has been implicated in adult-onset metabolic disease in offspring. However, the molecular mechanisms driving these paternal effects and the developmental processes involved remain poorly understood. One underexplored possibility is the role of paternally induced effects on placenta development and function. To address this, we investigated paternal high-fat diet-induced obesity in relation to sperm histone H3 lysine 4 tri-methylation signatures, the placenta transcriptome, and cellular composition. C57BL6/J male mice were fed either a control or high-fat diet for 10 weeks beginning at 6 weeks of age. Males were timed-mated with control-fed C57BL6/J females to generate pregnancies, followed by collection of sperm, and placentas at embryonic day (E)14.5. Chromatin immunoprecipitation targeting histone H3 lysine 4 tri-methylation (H3K4me3) followed by sequencing (ChIP-seq) was performed on sperm to define obesity-associated changes in enrichment. Paternal obesity corresponded with altered sperm H3K4me3 at promoters of genes involved in metabolism and development. Notably, altered sperm H3K4me3 was also localized at placental enhancers. Bulk RNA-sequencing on placentas revealed paternal obesity-associated sex-specific changes in expression of genes involved in hypoxic processes such as angiogenesis, nutrient transport, and imprinted genes, with a subset of de-regulated genes showing changes in H3K4me3 in sperm at corresponding promoters. Paternal obesity was also linked to impaired placenta development; specifically, a deconvolution analysis revealed altered trophoblast cell lineage specification. These findings implicate paternal obesity effects on placenta development and function as one potential developmental route to offspring metabolic disease.
Fast Evolution of SOS-Independent Multi-Drug Resistance in Bacteria
Authors: Zhang Le , Guan Yunpeng , Cheng Yuen Yee , Cokcetin Nural N , Bottomley Amy L , Robinson Andrew , Harry Elizabeth J , van Oijen Antoine , Su Qian Peter , Jin Dayong
Published: November 2024

The killing mechanism of many antibiotics involves the induction of DNA damage, either directly or indirectly, which triggers the SOS response. RecA, the master regulator of the SOS response, plays a crucial role in driving the evolution of resistance to fluoroquinolone antibiotics treated with a single dose of ciprofloxacin. However, the precise roles of RecA and SOS responses in the development of resistance under short-term β-lactam exposure remain unclear. In the present study, we observed a fast evolution of β-lactam resistance (20-fold increase in MIC in 8 hours) in
E. coli
after deleting RecA and exposing the bacteria to a single dose of ampicillin. Notably, once this type of resistance is established, it remains stable and can be passed on to subsequent generations. Unlike earlier studies, we found that the rapid development of resistance relies on the hindrance of DNA repair, a mechanism that operates independently of the SOS response. Additionally, we identified the rapid emergence of drug resistance associated mutations in the resistant bacterial genome, indicating the impairment of DNA repair. Through comprehensive transcriptome sequencing, we discovered that the expression of numerous antioxidative response genes is repressed in
recA
mutant resistant isolates, resulting in an excessive accumulation of ROS within the cells. This suggests that the induction of ROS drives the fast evolution of antibiotic resistance in RecA-deficient bacteria. Collectively, we show that the hindrance of DNA repair hampers cellular fitness, provides bacteria with genetic adaptability to survive in diverse stressful environments, and accelerates the evolution of antibiotic resistance.
Review of 'The fundamentally simple logic of language', by Luis H. González
Authors: Fábregas Antonio
Published: November 2024

Review of the following book:
González, L. H. (2020). The fundamentally simple logic of language. Oxford: Routledge. https://doi.org/10.4324/9781003139225
Forensic Anthropological Analysis of the Korean Empire’s Post-mortem Examination Report on Park Bong-Un of Unbong County
Authors: Hong Seonguk , Lee Soong Deok , Shin Dong Hoon
Published: November 2024

During the Joseon Dynasty of Korea, a reasonable investigation of the dead was well developed even before the introduction of modern forensic techniques from Western countries. Various reviews have been attempted on those investigation records currently stored in the Gyujanggak library, but an in-depth analysis has not been conducted on the extent to which the evidence mobilized at the time is valid from the perspective of modern forensic science. Therefore, we conducted a full-scale forensic review of the Gyujanggak record as an interdisciplinary study between forensic science and humanities. The case of Park Bong-Un which occurred in 1902 was investigated by Korean Empire officials who concluded that the deceased was killed by the beating of the suspect. The entire investigation of the Park Bong-Un case was described by the officials in detail, and the conclusion was made according to a credible process although various methods used in modern forensic investigation were impossible during the period.
Statistical Analysis of Forensic Autopsies in Busan and Gyeongnam: Changes and Characteristics in the Past 10 Years
Authors: Son In-Gyu , Na Joo-Young , Heo Jin-Haeng , Kwon Jeong-hwa , Jang Seon Jung
Published: November 2024

The cause and manner of death in the Busan and Gyeongnam regions were analyzed using autopsy data performed by the National Forensic Service Busan Institute (NFS BI) for 10 years—from 2014 to 2023. In addition, changes in the number of autopsy cases of elderly individuals aged 65 and older, were analyzed in the Busan and Gyeongnam regions. A total of 6,374 cases were classified, excluding autopsies from the Ulsan area and the Coast Guard, from the NFS BI data. Analysis of the manner of death revealed that 3,203 cases (50.3%) were unnatural deaths; 2,031 cases (31.9%) were natural deaths; and 1,140 cases (17.9%) were deaths of unknown cause. Among the unnatural deaths, accidents were the most common at 1,149 cases (18.0%), followed by suicide at 979 cases (15.4%); and homicide at 583 cases (9.1%). Among natural deaths, heart disease was the most common with 764 cases (37.6%), followed by vascular disease with 351 cases (17.3%). The proportion of the population aged 65 or older in Busan and Gyeongnam has been steadily increasing from 13.7% in 2014 to 21.6% in 2023. Accordingly, the number of autopsies on people aged 65 or older has increased from 72 in 2014 to 174 in 2023, and the number of autopsies on people aged 65 or older accounted for one-quarter of the total number of forensic autopsies commissioned by Busan/Gyeongnam, and performed by NFS BI in 2023. Therefore, we plan to introduce emerging issues relating to population aging and geriatric forensic medicine.
Tuberculous Meningoencephalitis with Skull Perforation Possibly Mistaken for Trauma: An Autopsy Case Report
Authors: Park Jae Hong , Park Kimhanbyeol , Eom Minseob
Published: November 2024

Although tuberculosis can affect various parts of the central nervous system, tuberculous meningitis is the most lethal form. Tuberculous meningoencephalitis and cranial tuberculosis are extremely rare. Therefore, the authors present an autopsy case of tuberculous meningoencephalitis resulting in skull perforation. This condition can be mistaken for trauma, which may cause forensic confusion. A 45-year-old woman died at home. External examination revealed an unhealed open wound on the left side of the occiput. The scalp incision revealed extensive congestion, purulent exudate, and an irregular perforation in the corresponding skull area. When the skull was opened, adhesion of the dura mater to the skull was found, accompanied by purulent inflammation. Cerebral edema and hydrocephalus were present, with necrosis in the upper part of the right basal ganglia. Pathological examination identified purulent and chronic granulomatous inflammation in the dura and brain parenchyma, with a few acid-fast bacilli detected. Additionally, an adenosquamous carcinoma measuring approximately 2.5×2 cm was found in the left upper lobe of the lung. This case highlights the importance of a thorough legal autopsy to accurately determine the cause of death, as the inflammatory changes in the scalp could be misinterpreted as trauma from a forensic perspective.
Unveiling the hidden depths: advancements in underwater image enhancement using deep learning and auto-encoders
Authors: Bantupalli Jaisuraj , Kachapilly Amal John , Roy Sanjukta , L. K. Pavithra
Published: November 2024

Underwater images hold immense value for various fields, including marine biology research, underwater infrastructure inspection, and exploration activities. However, capturing high-quality images underwater proves challenging due to light absorption and scattering leading to color distortion, blue green hues. Additionally, these phenomena decrease contrast and visibility, hindering the ability to extract valuable information. Existing image enhancement methods often struggle to achieve accurate color correction while preserving crucial image details. This article proposes a novel deep learning-based approach for underwater image enhancement that leverages the power of autoencoders. Specifically, a convolutional autoencoder is trained to learn a mapping from the distorted colors present in underwater images to their true, color-corrected counterparts. The proposed model is trained and tested using the Enhancing Underwater Visual Perception (EUVP) and Underwater Image Enhancement Benchmark (UIEB) datasets. The performance of the model is evaluated and compared with various traditional and deep learning based image enhancement techniques using the quality measures structural similarity index (SSIM), peak signal-to-noise ratio (PSNR) and mean squared error (MSE). This research aims to address the critical limitations of current techniques by offering a superior method for underwater image enhancement by improving color fidelity and better information extraction capabilities for various applications. Our proposed color correction model based on encoder decoder network achieves higher SSIM and PSNR values.
Detecting and forecasting cryptojacking attack trends in Internet of Things and wireless sensor networks devices
Authors: Reddy C. Kishor Kumar , Kaza Vijaya Sindhoori , R. Madana Mohana , Alamer Abdulrahman , Alam Shadab , Shuaib Mohammed , Basudan Sultan , Sheneamer Abdullah
Published: November 2024

This research addresses the critical issue of cryptojacking attacks, a significant cybersecurity threat where malicious actors covertly exploit computational resources for unauthorized cryptocurrency mining, particularly in wireless sensor networks (WSN) and Internet of Things (IoT) devices. The article proposes an innovative approach that integrates time series analysis with graph neural networks (GNNs) to forecast/detect cryptojacking attack trends within these vulnerable ecosystems. Utilizing the “Cryptojacking Attack Timeseries Dataset,” the proposed method emphasizes early detection and predictive insights to anticipate emerging attack patterns. Through rigorous experiments, the model demonstrated high accuracy with ARIMA achieving up to 99.98% on specific attributes and the GNN model yielding an accuracy of 99.99%. Despite these strengths, the ensemble approach showed a slightly lower overall accuracy of 90.97%. Despite the reduction in accuracy compared to individual models, the ensemble method enhances predictive robustness and adaptability, making it more effective in identifying emerging cryptojacking trends amidst varying network conditions. This research significantly contributes to enhancing cybersecurity measures against the evolving threat of cryptojacking in WSN and IoT environments by providing a robust, proactive defence mechanism.
V2I-VTL: IoT-Enabled adaptive traffic light controller and emission reduction at intersection
Authors: Khan Ajmal , Rahman Shams ur , Ullah Farman , Khattak Muhammad Ilyas , Bait-Suwailam Mohammed M. , El Sayed Hesham
Published: November 2024

Traffic congestion is a growing concern in urban centers worldwide, leading to significant delays, particularly for emergency vehicles such as fire trucks and ambulances. This not only increases emergency response time but also the risk of life and property loss. To address this issue, our research introduces a traffic control system that prioritizes emergency vehicle egress and mitigates intersection congestion. Other than validation through simulation, the system’s efficacy is further substantiated by real-world hardware implementation. The system employs an access point (AP) at intersections to receive location and direction data from approaching vehicles. Emergency vehicles are given precedence, while non- emergency vehicle data is used to adjust traffic light durations, thereby optimizing the traffic flow. The simulation results demonstrate the system’s reduced lane opening times and average waiting periods for emergency vehicles. Advancing from simulation to application, we have executed a real-world hardware validation at a high-traffic intersection. This phase entailed the precise installation and calibration of the necessary hardware components, transitioning from theoretical models to practical, operational technology. The hardware setup confirms the system’s practical viability and offers a more comprehensive assessment of its impact on traffic efficiency and emergency response times. This dual approach of simulation and hardware validation provides a thorough evaluation of the system’s capabilities, establishing a foundation for future traffic management solutions. Additionally, the implementation of the system leads to a notable reduction in CO2 emissions at intersections, contributing to environmental sustainability efforts.
A retrospective approach for evaluating ecological niche modeling transferability over time: the case of Mexican endemic rodents
Authors: Moreno-Arzate Claudia N. , Martínez-Meyer Enrique
Published: November 2024

Ecological niche modeling (ENM) is a valuable tool for inferring suitable environmental conditions and estimating species’ geographic distributions. ENM is widely used to assess the potential effects of climate change on species distributions; however, the choice of modeling algorithm introduces substantial uncertainty, especially since future projections cannot be properly validated. In this study, we evaluated the performance of seven popular modeling algorithms—Bioclim, generalized additive models (GAM), generalized linear models (GLM), boosted regression trees (BRT), Maxent, random forest (RF), and support vector machine (SVM)—in transferring ENM across time, using Mexican endemic rodents as a model system. We used a retrospective approach, transferring models from the near past (1950–1979) to more recent conditions (1980–2009) and vice versa, to evaluate their performance in both forecasting and hindcasting. Consistent with previous studies, our results highlight that input data quality and algorithm choice significantly impact model accuracy, but most importantly, we found that algorithm performance varied between forecasting and hindcasting. While no single algorithm outperformed the others in both temporal directions, RF generally showed better performance for forecasting, while Maxent performed better in hindcasting, though it was more sensitive to small sample sizes. Bioclim consistently showed the lowest performance. These findings underscore that not all species or algorithms are suited for temporal projections. Therefore, we strongly recommend conducting a thorough evaluation of the data quality—in terms of quantity and potential biases—of the species of interest. Based on this assessment, appropriate algorithm(s) should be carefully selected and rigorously tested before proceeding with temporal transfers.
Assessment of genotype by environment and yield performance of tropical maize hybrids using stability statistics and graphical biplots
Authors: Supriadi Dedy , Bimantara Yusuf Mufti , Zendrato Yuniel Melvanolo , Widaryanto Eko , Kuswanto Kuswanto , Waluyo Budi
Published: November 2024

Background

Enhancing maize grain yield in tropical regions faces significant challenges due to variability in agroclimate, soil conditions, and agroecosystems. Understanding genotype (G) by environment (E) interaction (GEI) in plant breeding is crucial for selecting and developing high-yielding genotypes adapted to diverse environments.

Methods

Ten maize hybrids, including eight candidates and two commercial varieties, were evaluated across ten environments in Indonesia using a randomized complete block design with three replications. The GEI effect and yield stability were assessed using stability statistics, additive main effects and multiplicative interaction model (AMMI), and genotype + genotype × environment (GGE) biplot methods.

Results and Discussion

Analysis of variance revealed a significant GEI effect, indicating differences in hybrid responses for grain yield (GY), allowing for stability analysis. G01 showed the highest GY based on the best linear unbiased prediction (BLUP) across environments. Correlation analysis indicated strong associations between stability statistics (YSi and S(6)) and GY, aiding in the selection of high-yielding hybrids. The integration of AMMI with the BLUP method, and weighted average of absolute scores (WAASB), enabled precise measurement of genotype stability. Overall, G01 (R0211), G04 (R0105), G05 (R0118), and G07 (R0641) emerged as high-yielding, stable hybrids based on stability statistics, AMMI, GGE biplot, and WAASB rankings. These hybrids offer promising candidates for maize genetic improvement programs in tropical regions.
Electrical conductivity of forage subjected to different sobbing times and water volumes
Authors: Tremea Marta Gubert , Madruga Natalia Pedra , Rossetti Cristina , Madruga Francine Bonemann , Pereira Newton Magno Guidotti , Tunes Lilian Madruga de
Published: November 2024

In Brazil, forage grasses constitute the basis of the herd's diet. The electrical conductivity test stands out for generating quick responses to differentiate batches at different levels of deterioration. However, further studies are needed to improve this practice for forage species. The objective of this work was to evaluate the electrical conductivity in several forage seeds, with different volumes of water soaked and soaking time. The experimental design used was completely randomized in a 3x4 factorial scheme, consisting of three volumes of water for the imbibition solution (25, 50 and 75 mL) and four imbibition times (0 hrs, 8 hrs, 16 hrs and 24 hrs). From the tests it was concluded that with an increase in the soaking time, and a smaller volume of water to perform electrical conductivity, the leaching of nutrients increases and consequently less vigor of the seeds.
Empirical Review of Studies on Staff Development and Teachers’ Job Productivity in Educational Institutions
Authors: Umar Babayi Murtala , Maghra Harrison Gideon , Candy Michael Fwah
Published: November 2024

The teacher is part of the most important components of the education system is the teacher. Development programmes designed for teachers are germane aspects of the total education processes. Teacher training is essential exercises that improves the subject matter mastery, teaching methodology and classroom management. This paper reviews empirical studies on staff development and teachers’ job productivity in educational institutions from 2019 to 2024. The review focuses on the staff development on teachers’ job productivity. Two objectives guided the review. The methodology used was a systematic review of 15 empirical papers with 13 focusing on staff development and 2 on teachers’ job productivity. The studies used various research designs, including correlational, survey, experimental, qualitative, and case study research. Data collection methods included questionnaires and interviews, which were adopted, adapted, and self-structured. Data analysis was mainly descriptive statistics, with some authors focusing on multiple sub-variables. The findings aligned with the study's titles and were well organized. The study found that staff development and teachers’ job productivity contribute to national development and innovation, teachers training, seminars, workshops, conference, mentoring and coaching should be encouraged.
Assessing the Factors Hindering the Implementation of Adult Education in Open and Distance Learning System in Mbeya, Tanzania
Authors: Amos Thomas , Salvatory Mhando
Published: November 2024

The study assessed the factors hindering the implementation of adult education in Open and Distance Learning system in Mbeya, Tanzania whereby two research objective namely to examined the practice of adult education through online distance learning in Mbeya region and exploring issues that hinder the practice of adult education through online distance learning. Mixed research approach employed and has a sample size of 56 respondents where by 40 respondents were adult education learners. The study found that the practiced programme not well known among rural society, even local government officials did not knew about adult education, some thought AE is teaching adult reading and writing. Moreover, physical facilities were not satisfactory. Most learners and teachers not satisfied with the availability, relevance and adequacy of teaching and learning materials (textbooks, curriculum, other curriculum support materials, storybooks, technological facilities). The study concludes that the practice of adult education in Mbeya region had positive impact basing on its modes of operands and was among the strategies that revealed to motivate and enhances the programme to gain its popularities. It recommended that more training should offered to learning institution and they should cooperate with the Tanzania Commission for Universities and public universities in Tanzania and NACTVET to use the ODL system. Finally, it is essential that the government of Tanzania to support all institutions through giving the financial and non-financial support as well the qualified human resources including leaders who know the significant of ODL system in practicing the adult education in Tanzania.
A Comparative Study of Decadal Labour Share for Indian Manufacturing Industries
Authors: Dutta Dip , Dasgupta Byasdeb
Published: November 2024

Since the 1980s and 1990s, there have been concerns that many parts of the workforce have not experienced significant improvements in labor market outcomes, such as wages, job security, and working conditions. Many analysts focused on India’s labour markets express apprehension about the slow growth of employments in the organized sector and draws attention to re-investigate the wage productivity gap and the conditions of labour market in Indian manufacturing industries. The major question that we pose in this paper is that: How does labour share and labour share growth trends differ across decades at aggregate level for Indian manufacturing industries? Our comprehension of the wage productivity disparity in Indian manufacturing across decades depends on the value of labour share growth which we have derived straightforward and stems from the definition of labour share. Here, we have calculated the labour share and labour share growth curve at the aggregate level across decades from Annual Survey of Industries (ASI) data at 3 digit National Industrial Classification (NIC) for Indian manufacturing industries from 1973-74 to 2019-20. The results show that in each decade there is an upward shift in labour share and the reason of this upward shift is the more increase in real net value added than the increase in real wages in each decade. The main cause of this falling labour share trend across decades is the stagnation in real wages. The real wages have not risen a significant level over the decades, and it cannot nullify the effect of huge amount of increase in real net value added. Our policy imperatives might be the rigorous implementation of minimum wage regulations for different industry categories
PREVALÊNCIA E FATORES ASSOCIADOS AO ESTRESSE, ANSIEDADE E DEPRESSÃO EM MULHERES NO PERÍODO FÉRTIL ATENDIDAS NA ATENÇÃO PRIMÁRIA À SAÚDE DE UM MUNICÍPIO DO RECÔNCAVO BAIANO
Authors: Peixoto Santiago Lara , Hayasi Pinho Paula , Assis Oliveira Clotilde , Da Mota Santana Jerusa , Santos Djanilson Barbosa dos
Published: November 2024

Mulheres em idade fértil (15 a 49 anos) representam uma grande parcela da população total de um território de saúde. São diversos os fatores que interferem diretamente na saúde mental da mulher, alguns deles fazem parte do contexto de vida de cada uma, que são associados aos aspectos socioculturais, econômicos e ambientais. Objetivou-se identificar a associação entre fatores sociodemográficos e ocorrência de depressão, ansiedade e estresse em mulheres em idade fértil atendidas na Atenção Primária à Saúde de uma cidade do Recôncavo da Bahia. Trata-se de um estudo transversal com uma amostra de 73 mulheres em idade fértil. A coleta de dados ocorreu em quatro Unidades de Saúde da Família, no período de outubro de 2022 a abril de 2023. Aplicou-se a Escala de Depressão, Ansiedade e Estresse (DASS-21) e um questionário com dados sociodemográficos. Para avaliar a relação entre as variáveis de exposição e desfecho adotou-se a análise multivariada de Poisson. Os resultados apontaram que duas variáveis, escolaridade e estado civil, representantes das condições sociais das mulheres foram associadas positivamente à ocorrência dos desfechos estudados. Observou-se, portanto, associação positiva tanto entre a variável escolaridade e as variáveis de depressão (RP= 3,45; IC95%= 1,23-9,69), ansiedade (RP= 5,73; IC95%= 3,52-9,33) e estresse (RP= 6,40; IC95%= 3,94-1,04); quanto à variável estado civil e as variáveis de depressão (RP= 1,74; IC95%= 1,06-2,87), ansiedade (RP= 1,63; IC95%= 1,01-2,64) e estresse (RP= 1,76; IC95%= 1,06-2,93). Os resultados obtidos mostraram associação direta entre as variáveis escolaridade e estado civil.
SÍNDROME METABÓLICA: UM ESTUDO DE PREVALÊNCIA E DE ASSOCIAÇÃO AO CONSUMO ALIMENTAR E USO DE MEDICAMENTOS PARA EMAGRECIMENTO EM MULHERES ADULTAS USUÁRIAS DE UNIDADES BÁSICAS DE SAÚDE
Authors: Cabral Larissa Emanuele , Malta Gabriella Fabiane de Assis , Cecilio Sumaya Giarola , Silva Douglas Roberto Guimarães , Resende Thainá Richelli Oliveira , Cecílio Samyra Giarola
Published: November 2024

Introdução: A obesidade central quando associada com a hipertensão arterial sistêmica, hiperglicemia e/ou dislipidemia forma um complexo de distúrbios metabólicos, caracterizando a Síndrome Metabólica (SM). Para tentar reverter essa situação, muitos indivíduos utilizam medicamentos e fitoterápicos para emagrecimento, utilizando-os ou não de forma inapropriada. Dessa forma, o trabalho objetivou avaliar a prevalência e a associação entre SM, consumo alimentar e utilização de fármacos para emagrecimento por mulheres adultas usuárias das Unidades Básicas de Saúde de São João Del-Rei, Minas Gerais. Metodologia: Trata-se de estudo com abordagem quantitativa e delineamento transversal, no qual participaram mulheres entre 18 a 65 anos. Coletou-se dados referentes à idade, peso, altura, circunferência abdominal e presença de doenças crônicas não transmissíveis, uso de medicamentos e fitoterápicos para emagrecimento e o perfil de consumo alimentar. Resultados: A prevalência de Síndrome Metabólica foi de 15,6% e, ao identificar os fatores associados à presença de SM, observou-se relação com idade, peso, IMC (Índice de Massa Corporal) (especialmente para obesidade grau II) e circunferência abdominal. Relatou-se a utilização, no total, de 15 tipos de medicamentos e 32 fitoterápicos, em sua maioria sem prescrição médica, os quais em grande parte não ocasionaram reações adversas. Constatou-se, ainda, que o consumo de carboidratos simples, principalmente diariamente e mensalmente e de adoçantes (todos os dias) foi menor entre as portadoras de SM. Conclusão: A Atenção Básica do Sistema Único de Saúde (SUS) enfrenta grandes desafios diante do atual panorama do país, tornando-se uma problemática importante a ser discutida.
Dentifrícios experimental contendo nistatina: efeito antifúngico e características fisicoquímicas
Authors: Oliveira Ellen Caroline Araújo da Silva , Macedo Maria Thais Soares , Nunes Jocianelle Maria Félix Fernandes , Sampaio Fábio Correia , Farias Isabela Albuquerque Passos
Published: November 2024

Introdução: A candidíase oral é uma das mais frequentes infecções oportunistas da cavidade oral, representada pelo crescimento excessivo de Candida albicans, seguido por Candida glabrata. O protocolo de tratamento envolve terapia com antifúngicos e higiene oral. O dentifrício é um produto de uso rotineiro na clínica odontológica e na vida da população,incrementando a higiene mecânica e sendo veículo para agentes antifúngicos. Dentre esses, destaca-se a nistatina (NIS), em suspensão oral, pela sua eficácia clínica e reduzido efeito adverso. Objetivo: Desenvolver e avaliar dentifrício experimental contendo nistatina. Metodologia: Foi desenvolvido um dentifrício a partir de uma formulação base por adição de nistatina em três concentrações. A atividade antifúngica foi avaliada pela Concentração inibitória mínima (CIM) e teste de difusão em ágar. Foram avaliadas as propriedades físicas do dentifrício. Os dados foram apresentados por média e aplicado o teste ANOVA. Resultados: O valor de CIM da nistatina foi 0,05 ± 0,017 µg/ mL. A atividade antifúngica apresentou valores de 17,3 ± 3,93 mm, 20,40 ± 8,08 mm e 20,20 ± 3,34 mm, para D1, D2 e D3, respectivamente (p>0,05). Todas as formulações apresentaram capacidade espumante, porém D1 apresentou maior capacidade de formação de espuma (18,7%). As três formulações apresentaram capacidade de espalhamento aproximado a 7 cm. As formulações apresentaram capacidade de limpeza semelhante ao controle negativo. Conclusão: Os dentifrícios apresentaram atividade antifúngica contra C. albicans e exibiram propriedades físicas satisfatórias, sem influência negativa pela incorporação da nistatina.
Efeitos da ozonioterapia sobre as fibras colágenas e elásticas no reparo cutâneo – Um estudo histomorfométrico em ratos
Authors: Hegouet Isadora de Carvalho , Lima Sarah Souza , Medrado Alena Ribeiro Alves Peixoto
Published: November 2024

ResumoObjetivo: analisar os efeitos da ozonioterapia, sob duas formas de apresentação – gás e óleo ozonizado –, para biomodulação defibras colágenas e elásticas em ferimentos cutâneos experimentalmente induzidos em ratos. Metodologia: foram utilizados 30 ratosWistar machos, distribuídos aleatoriamente em três grupos experimentais: GC (grupo controle), GGO (grupo tratado com gás ozônio) eGOO (grupo tratado com óleo ozonizado). Todos os animais foram submetidos a uma incisão cirúrgica no dorso, após o que os gruposGGO e GOO receberam terapia com ozônio diretamente na lesão, iniciada imediatamente após a cirurgia e continuada até o 3º dia.Metade dos animais foi eutanasiada ao final de cinco dias, enquanto a outra metade após dez dias de experimento. Nos respectivosperíodos de avaliação, secções de pele foram obtidas e coradas com Sirius vermelho para análise das fibras colágenas, e Orceína deWeight para o estudo das fibras elásticas. Essas secções de fibras colágenas e elásticas foram sujeitas às análises histomorfométricae estatística dos dados. Resultados: observou-se uma crescente compactação das fibras colágenas em direção à superfície da lesãonos grupos tratados com ozônio. As fibras elásticas, por sua vez, apresentaram-se distribuídas de forma esparsa, com destaque para o5º dia, no grupo GGO. A presença de colágeno se mostrou estatisticamente significante no 5° dia do experimento no grupo GGO emrelação ao GC (p=0,016). As fibras elásticas, exibiram resultado estatisticamente significativo no 5° dia no grupo GGO em relação aoGC (p=0,016), bem como, no 10° dia, no GOO em relação ao GC (p=0,016). Conclusão: durante a fase proliferativa do reparo cutâneo,a ozonioterapia desempenhou um papel biomodulador, pois promoveu um aumento significativo das fibras colágenas e elásticas namatriz extracelular, nos diferentes períodos do estudo. Essa modalidade terapêutica emerge como uma abordagem promissora parao estudo dos processos de cicatrização em diversos tipos de tecidos.
Hipercolesterolemia familiar bialélica: estudo de caso
Authors: Santos Anna Claudia Monteiro Luz , Lopes Taísa Machado- , Nascimento1, Samuel Ulisses Chaves Nogueira do , Meyer Roberto
Published: November 2024

ResumoIntrodução: a hipercolesterolemia familiar (HF) é uma doença genética do metabolismo das lipoproteínas, de herança autossômicadominante. Caracteriza-se por níveis muito elevados do colesterol da lipoproteína de baixa densidade (LDL-c) no sangue e pelapresença de sinais clínicos como xantomas tendíneos, xantelasmas, arco corneano. Os depósitos vasculares promovem ateroscleroseprogressiva e prematura, com consequente doença arterial coronariana e aumento da morbidade e mortalidade. Objetivo: descrevero rastreamento em cascata de uma família brasileira de portadores de HF. Metodologia: cinco membros de uma família, em que todossão pacientes acompanhados pelo serviço de pediatria, genética médica e cardiologia do Ambulatório Magalhães Neto do HospitalUniversitário Professor Edgard Santos (HUPES), responderam questionários sobre história clínica, exame físico, antecedentes médicos,antecedentes familiares, exames complementares e realizaram testes genéticos. Resultados: o caso-índice apresentou 2 variantespatogênicas no gene LDLR, sendo uma variante patogênica, c.1118G>A, p. (Gly373Asp), no gene LDLR, em heterozigose, e a outravariante patogênica, c.1176C>A, p. (Cys392*), no gene LDLR, em heterozigose. Apresentou também uma variante de significado incerto,c.12635C>G, p. (Thr4212Ser), no gene APOB, em heterozigose. A genitora do caso-índice apresenta variante patogênica c.1118G>A: p.(Gly373Asp), no gene LDLR, em heterozigose; uma variante patogênica, c.796G>T: p. (Gly266*), no gene LIPA, em heterozigose; e umavariante de significado incerto, c.12635C>G, p. (Thr4212Ser), no gene APOB, em heterozigose. Conclusão: os achados contribuírampara o diagnóstico clínico e molecular, o tratamento e o aconselhamento genético de uma família com hipercolesterolemia familiar.
Experimental Investigation Of Lightweight Concrete Using Coconut Shells And Crushed Glass As Partial Aggregates
Authors: Rana Abhishek , Gupta Dr. Rahul Das
Published: November 2024

The growing demand for natural aggregates in concrete production has led to concerns regarding the
environmental impact and depletion of resources. This research investigates the mechanical properties of
concrete modified with coconut shells and crushed glass as partial substitutes for conventional aggregates, aiming
to promote sustainable construction practices. Various replacement levels (0%, 6%, 12%, 18%, 24%, and 30%
by weight) were tested in M30 concrete mixes using Ordinary Portland Cement (OPC) and natural aggregates.
The findings reveal significant alterations in concrete properties due to these substitutions. While coconut shells
led to a modest reduction in early strength and workability-with a maximum impact value increase to 32.53%—
they provided adequate strength for applications with lower surface wear, peaking at a crushing value of 40.03%.
Conversely, crushed glass demonstrated superior mechanical performance, achieving an impact value of 35.16%
and contributing positively to both early compressive strength (25.11 N/mm²) and long-term strength (37.73 N/mm²). Additionally, the inclusion of glass resulted in better abrasion resistance, with maximum values reaching 42.53%, compared to 41.20% for coconut shells
Analysis Of Connectivity And Accessibility Towards Customer Satisfaction Through Customer Experience At Yogyakarta International Airport
Authors: . .
Published: November 2024

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FDI, Corruption And Tax Revenue Performance In Nigeria And Kenya
Authors: (ACTI) Dr. Pere-Ere Grace Ikidi , Okoh Dr. John Onuwa
Published: November 2024

The study's aim is to investigate the moderating influence of corruption in the relationship between foreign direct
investment and tax revenue performance in Nigeria and Kenya. The ex-post factor research design was used in
this study. The data was secondary in nature, spanning the years 2012 to 2023 and collected from the World Bank
Group and Transparency International. Data was analysed using descriptive, correlation, and regression
methods. According to the report, foreign direct investment (FDI) has a positive and significant influence on
Nigerian tax income. Furthermore, corruption was shown to have a substantial role in moderating the influence
on FDI and tax revenue performance in Nigeria; however, this function was negative, implying that higher levels
of corruption may lower the positive impact of FDI on tax revenue performance. Evidence from Kenya suggests
that FDI and corruption have a beneficial but negligible influence on tax revenue performance. Additionally,
corruption was revealed to play a negative moderating influence in the relationship between FDI and tax revenue performance. Based on the findings, the report suggests enacting strong anti-corruption legislation and regulations, increasing government openness, and strengthening anti-corruption agencies.
Reflection on the research on and implementation of biorefinery systems – a systematic literature review with a focus on feedstock
Authors: Wenger Julia , Stern Tobias
Published: May 2019

Te concept of sustainably processing biomass into a spectrum of products and bioenergy is thousands of years old. Large‐scale utilization of such processes existed in the 19th century and the term biorefinery first appeared in the late 20th century. This review addresses how different feedstock classes, products, and regions have been described in the scientific literature on the development of biorefineries (1999–2017). The results of a systematic literature review were compared with information included in two reports on the implementation of biorefineries to identify similarities and differences between theory (described in the literature) and practice (carried out in industry). The number of scientific articles per year on this topic has increased over the last decade, particularly in the fields of natural sciences and engineering. The first authors of these articles are primarily affiliated with North American and European institutions. References to lignocellulosic raw materials (especially residues, but also dedicated crops) in the feedstock are by far the most frequent and those to aquatic biomass have also increased over time. Most of the products mentioned are related to energy products (mainly fuels), and the heterogeneous class of chemicals was also strongly represented. We examined two reports on existing biorefineries in Europe and identified differences between the roles of food‐crop‐based biorefineries and lignocellulosic‐feedstock biorefineries in terms of research and practice. New studies on the practical implementation of biorefineries should be carried out, with particular attention to these discrepancies. © 2019 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Chemical Industry and John Wiley & Sons, Ltd.
The “Heart” of depression during early adolescence
Authors: Tu Kelly M. , Li Xiaomei , Cohen Joseph R.
Published: May 2019

This study examined the concurrent associations linking youths’ parasympathetic nervous system activity, specifically baseline respiratory sinus arrhythmia (RSA) and respiratory sinus arrhythmia reactivity (RSAR; vagal withdrawal), with youth depression risk in a community sample of young adolescents. Youth gender was examined as a moderator of associations. Participants included 100 youth (53% boys; M age = 11.05 years, SD = 0.33; 43% ethnic minorities), along with their mothers and teachers. Youth and mothers participated in a laboratory protocol involving a peer problem‐solving conversation, during which youths’ physiological activity was measured. Youth reported on their depressive symptoms. Teachers reported on youth depression risk via internalizing symptoms and emotion regulation (e.g., emotion lability/negativity). Results from regression analyses revealed that youths’ vagal withdrawal during the mother‐youth peer problem conversation was associated with lower youth‐reported depressive symptoms. Further, gender moderated the associations linking youth baseline RSA and RSAR with youth depression risk. Specifically, among girls but not boys, higher baseline RSA was associated with lower depressive symptoms and emotion lability/negativity, and higher RSAR (i.e., vagal withdrawal) was linked with lower internalizing symptoms. Findings contribute to the relatively small literature linking youth parasympathetic functioning with depression risk, and point to specific implications for girls.
Case of renal mucinous tubular and spindle cell carcinoma with high nuclear grade
Authors: Hatayama Tomoya , Sekino Yohei , Shikuma Hiroyuki , Mukai Sakurako , Muto Masayuki , Miyamoto Shunsuke , Sadahide Kosuke , Fukuoka Kenichiro , Fuji Shinsuke , Goto Keisuke , Shinmei Shunsuke , Hieda Keisuke , Inoue Shogo , Hayashi Tetsutaro , Teishima Jun , Kuroda Naoto , Sentani Kazuhiro , Yasui Wataru , Matsubara Akio
Published: May 2019

Introduction

Renal mucinous tubular and spindle cell carcinoma is a rare subtype of renal cell carcinoma newly added to the World Health Organization classification in 2004. Although it has been considered as a tumor with good prognosis, aggressive cases have recently been reported.

Case presentation

A 52‐year‐old man was diagnosed as having left renal cell carcinoma. Open radical left nephrectomy and left‐sided pelvic lymph nodes dissection were performed. Pathological diagnosis revealed a renal mucinous tubular and spindle cell carcinoma with high nuclear grade and extra‐regional lymph nodes metastasis classified as pT3aN0M1. After nephrectomy, metastasis at second lumbar vertebra and lymph nodes recurrence were occurred.

Conclusion

This tumor with high nuclear grade may be potentially aggressive and carries a poor prognosis.
Trait‐based analysis of subpolar North Atlantic phytoplankton and plastidic ciliate communities using automated flow cytometer
Authors: Fragoso Glaucia Moreira , Poulton Alex James , Pratt Nicola Jane , Johnsen Geir , Purdie Duncan Alastair
Published: May 2019

Plankton are an extremely diverse and polyphyletic group, exhibiting a large range in morphological and physiological traits. Here, we apply automated optical techniques, provided by the pulse‐shape recording automated flow cytometer—CytoSense—to investigate trait variability of phytoplankton and plastidic ciliates in Arctic and Atlantic waters of the subpolar North Atlantic. We used the bio‐optical descriptors derived from the CytoSense (light scattering [forward and sideward] and fluorescence [red, yellow/green and orange from chlorophylla, degraded pigments, and phycobiliproteins, respectively]) and translated them into functional traits to demonstrate ecological trait variability along an environmental gradient. Cell size was the master trait varying in this study, with large photosynthetic microplankton (> 20 μm in cell diameter), including diatoms as single cells and chains, as well as plastidic ciliates found in Arctic waters, while small‐sized phytoplankton groups, such as the picoeukaryotes (< 4μm) and the cyanobacteriaSynechococcuswere dominant in Atlantic waters. Morphological traits, such as chain/colony formation and structural complexity (i.e., cellular processes, setae, and internal vacuoles), appear to favor buoyancy in highly illuminated and stratified Arctic waters. In Atlantic waters, small cell size and spherical cell shape, in addition to photo‐physiological traits, such as high internal pigmentation, offer chromatic adaptation for survival in the low nutrient and dynamic mixing waters of the Atlantic Ocean. The use of automated techniques that quantify ecological traits holds exciting new opportunities to unravel linkages between the structure and function of plankton communities and marine ecosystems.