bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Ultrasonographic Approach To Evaluate Fluid Responsiveness in Critically Ill Patients
Authors: Innocenti Francesca , Savinelli Caterina , Coppa Alessandro , Tassinari Irene , Pini Riccardo
Published: June 2022

Purpose
In patients with acute circulatory failure, we tested the feasibility and accuracy of an approach based on echocardiography and lung ultrasound to evaluate fluid responsiveness (FR).
Methods
We enrolled 113 consecutive patients admitted to the Emergency Department High-Dependency Unit of Careggi University-Hospital from January 2015 to June 2020. We assessed the inferior vena cava collapsibility index (IVCCI) and the variation of aortic flow (VTIAo) during the passive leg raising test (PLR). We performed a lung ultrasound to verify the presence of interstitial syndrome. FR was defined as an increase in the VTIAo > 10% during PLR or IVCCI ≥ 40%. FR patients were treated with fluid and those non-FR with diuretics or vasopressors. The therapeutic strategy was reassessed after 12 hours and the goal was to maintain the strategy based on the initial evaluation.
Results
among 51 FR patients, at lung ultrasound, 15 patients showed basal interstitial syndrome and 4 all-lung involvement. One fluid bolus was given to 51 patients. Among 57 non-FR patients, 26 patients showed interstitial syndrome at lung ultrasound (basal fields in 14, all lungs in 12). We administered diuretics to 21 patients and vasopressors to 4 subjects. We had to change the initial treatment plan in 5 (9%) non-FR patients and in 6 FR patients (12%, p = NS). In the first 12 hours after the evaluation, non-FR patients significantly less fluids compared to those FR (1119 ± 410 vs 2010 ± 1254 ml, p < 0.001).
Conclusions
the approach involving echocardiography and lung ultrasound allowed an accurate evaluation of the FR among critically ill patients.
Quantum Advantage on Machine Learning Models
Authors: Tomono Takao , Natsubori Satoko
Published: June 2022

Quantum machine learning is one of most exciting prospective applications of quantum technologies. Quantum kernel SVM is one of most popular methods for classifiers. However, there are few reports that show the quantum advantage in learning model construction compared with classical learning models. In this work, we investigated the process of learning model construction of quantum machine learning by using an evaluation index and ROC space graph. The behaviour between quantum and classical machine learning is different, and the quantum learning model is the method to decrease the false positive rate from high false and true positive rates that is based on quantum superposition. In summary, we have demonstrated the effect of quantum superposition on quantum machine learning for the first time from actual experimental results. This truth supports that quantum machine learning can build an outline of learning models faster than classical methods even if the number of original data is smaller.
Distribution of Diatoms in the Surface Sediments of the Seas of Eastern Siberia and the Arctic Ocean
Authors: Obrezkova M. S. , Tsoy I. B. , Kolyada A. E. , Shi X.
Published: June 2022

The present study quantitatively and qualitatively analyzed the diatoms in samples of the surface sediments collected from the seas of Eastern Siberia and the Arctic Ocean (AO) in 2016 and 2018. Compared with the end of the last century, there were significant changes in species composition and quantitative ratio of the diatom assemblages in the sediments from the Arctic Ocean and the Laptev and East Siberian Seas (ESS). In contrast, the diatom assemblages in the sediments from the Chukchi Sea had not significantly changed in terms of species composition or quantitative ratio over the same three decades. The observed transformations in the diatom assemblages of the surface sediments were associated with substantial alterations in water temperature, current flow, salinity, admixture, ice melting, and prolonged ice-free periods associated with global warming in the Northern Hemisphere in recent decades. The foregoing processes have clearly had strong impacts on the environment and the biota of the Arctic region.
Mapping of glacial lakes and glacial lake outburst flood in Kinnaur district, Himachal Pradesh using remote sensing and GIS
Authors: Rongali Gopinadh , Tiwari K. C. , Vishwas Poonam
Published: June 2022

Glacial lake outburst floods (GLOFs) are a severe and escalating threat to livelihoods and infrastructure in high-mountain areas around the world. To implement a first-order assessment of GLOF risk across the Kinnaur district of Himachal Pradesh (HP), we combine modelling approaches that capture both current and future potential for GLOF triggering, quantification of affected downstream areas, and assessment of the underlying societal vulnerability to such climate-related disasters. As a result, the assessment takes into account both current glacial lakes and future lakes predicted to occur as glaciers retreat. Current hazard, vulnerability, and exposure indices are combined to indicate various risk 'hotspots,' demonstrating that high GLOF risk might occur well downstream from the glaciated headwaters where threats arise in some cases. Landsat images for the years 1989, 1998, 2008 and 2018 were used to map glacier lakes. Cartosat DEM (30 m) was used for computing topographic information including maximum, minimum, mean elevation, slope, and aspect. ArcGIS 10.8 was used to generate other characteristics such as area, slope, aspect, and drainage network. The maximum likelihood classification (MLC) algorithm was used to create the land use and land cover (LULC) maps using the supervised classification technique. To augment the findings, the study also uses the indices i.e. NDSI, NDWI, NDPI. based on the data a total of 39 glacial lakes were identified of which 10 lakes were found dangerous lakes having area > 0.1 Km2 Trans-national GLOFs originating in China's upper Satluj River Basin, in particular, pose a threat to eastern HP's downstream territories. In the future deglaciated scenario, most administrative units are expected to have a large increase in GLOF danger levels as lakes grow closer to steep headwalls, where impacts from falling ice and rock could trigger outburst occurrences. Strengthening resilience and capacities to lower the current GLOF risk will be a critical first step toward adjusting to future problems in such situations.
Comparison of knee function after reconstruction with Posterolateral Corner injury and with or without Posteromedial Corner injury: a prospective cohort study
Authors: Zhu Yanlin , Fu Weili
Published: June 2022

Background
In the multiple ligament injury of the knee joint, apart from the anterior cruciate ligament and the posterior cruciate ligament, the Posterolateral Corner and the Posteromedial Corner are two structures that are easily overlooked. If not properly identified and repaired in one stage, the knee joint may be unstable. even failure of cruciate ligament reconstruction. The purpose of this article was to evaluate the effect of knee joint recovery after PLC with or without PMC injury.
Methods
From 2016 to 2020, we screened a total of 2564 patients, of which 292 patients met the inclusion and exclusion criteria. In the end, a total of 44 people completed the study. Follow-up was performed at 1, 3, 6, 9, and 12 months after surgery. We used pain visual analog scale (VAS)for pain, IKDC score, Lysholm score, Tegner score. Opti-knee (a portable motion analysis system) was used to evaluate the stability of knee joint at one year.
Results
The knee joint function of PLC group and PLC combined PMC group was better than that before operation at 3 or 6 months after operation. Except for IKDC at 9-month follow-up and Tegner score at 9-month and 12-month follow-up, there was no significant difference between the other groups.
Conclusions
PLC and PLC combined with PMC injury showed similar prognostic effects, although the PLC group was numerically superior to the other group. We recommend primary repair and reconstruction in patients with confirmed PLC and PMC injuries to achieve the best postoperative recovery.
Impact of Land use and Land cover change on stream flow of Beshilo watershed, Ethiopia
Authors: Eshete Asalf Shumete , Affessa Girum Metaferia
Published: June 2022

Land degradation is a series problem in Ethiopia highlands, particular in abbay basin reflected in the form of soil erosion and soil fertility decline from time to time. Beshilo catchment is one of the Abbay basin tributary, which covers 5,700 km2; this shows that the problem of the catchment is significant effect in Abbay basin development. In this study the impact of Land use/ Land cover change on annual outflow contribution of Beshilo Catchment is evaluated, distributed physically based hydrological model known as soil and water assessment tool (SWAT) model was used this study. Changes were analyzed and characterized impacts on surface runoff were evaluated. The model was calibrated and validated over the gauged upper reaches of catchments of Gummara River. The model was calibrated for the period from 1999–2008 and validated for the period from 2009–2014. The performance of the model was evaluated on the basis of performance rating criteria, coefficient of determination, Nash & Sutcliff efficiency. The overall performance of the models gives good result. For this study the land use land cover change scenario, were developed using its change. From the land cover change analysis results it was found that there has been a substantial decline of forest lands, shrub lands, grass lands and expansion of agricultural land. The SWAT modeling shows the result indicated that the mean annual stream flow were increase by 7.4% with 2004 LULC from 1996 LULC and increased by 6.8% with 2013 LULC from 1996 LULC.
Intermediaries in phosphotransfer: structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs
Authors: Brüderlin Mitchell , Böhm Raphael , Hiller Sebastian , Schirmer Tilman , Dubey Badri
Published: June 2022

In two-component systems, the information gathered by the histidine kinase (HK) is relayed to the cognate response regulator (RR). Thereby, the phosphoryl group of the auto-phosphorylated HK is transferred to the receiver domain of the RR to allosterically activate its effector domain. In contrast, multi-step phosphorelays comprise at least one additional Rec domain (Recinter) that is part of the HK and acts as an intermediary for phosphoryl-shuttling. While RR Rec domains have been studied extensively, little is known about Recinter domains and their potentially discriminating features. As a bona-fide Recinter domain, here we have studied the C-terminal Rec domain of the hybrid HK CckA (CckARec) from Caulobacter crescentus by X-ray crystallography and NMR spectroscopy. CckARec exhibits the canonical Rec-fold, though with a degenerated α4 helix, in which all active site residues are pre-arranged for phosphoryl-binding. BeF3- binding does not alter secondary structure nor the oligomeric state, indicating the absence of allosteric changes, the hall mark of RRs. Based on structural modeling and sequence co-variation analysis, we present a detailed picture for the intra-molecular association of the CckA DHp/Rec domains and discuss the role of a FATGUY motif, a distinguishing feature of CckARec orthologs.
Characterization of thiamine pyrophospho kinase of vitamin B1 biosynthetic pathway as a drug target in Lesishmania donovani
Authors: Kumar Ravi Ranjan , Jain Ravi , Sharma Veena , Singh Shailja
Published: June 2022

Vitamin B1 is an essential cofactor required by carbohydrate-metabolizing enzymes such as Transketolases. Humans obtain these vitamins from their diet, although certain bacteria, yeast, plants, and lower eukaryotes synthesize them de novo. Because of the specificity of this system, the enzymes involved are amenable to therapeutic manipulation. In the final step of Thiamin Pyrophosphate (TPP) biosynthetic pathway, Thiamine Pyrophospho Kinase (TPK) converts Thiamin into its active form, TPP, opening an avenue to investigate the functional importance of this enzyme and the pathway's dispensability in Leishmania donovani, a protozoan parasite that causes visceral leishmaniasis. ldtpk gene encodes a 545 amino acid protein with a molecular mass of 58.4 kDa. LdTPK over-expression, antibody generation, cellular localization, enzyme kinetics, and inhibition assays with Oxythiamin and Pyrithiamin may provide a sound platform for the discovery of potential inhibitors for this enzyme. As a result, an in-depth analysis of the enzymes involved in TPP biosynthesis in L. donovani has the potential to generate novel therapeutic strategies for Leishmaniasis.
Analysis of strategy and efficacy clinical treatments of Kümmell disease
Authors: Xu Sheng , Ding Wei-guo , Sheng Hong-feng , Liu Jian , Song Hong-pu , Zhu Jia-fu , Xin Long , Xu Xin-wei
Published: June 2022

Objective: To investigate the most appropriate and effective clinical treatment strategies according to the characteristics of the different types of Kümmell disease. Methods: A retrospective analysis was performed of 48 patients with Kümmell disease treated in our hospital, for which complete follow-up data were available. The cases were evaluated according to Li classification, combined with clinical symptoms and imaging findings. The cases were classified into the following types. Type I: vertebral body height < 20% and no intervertebral disc degeneration from adjacent segments; Type II: vertebral body height loss > 20% and accompanied by degeneration or mild instability of intervertebral discs at adjacent segments; Type III: posterior vertebral cortical rupture and dural sac compression, and some accompanied by spinal cord nerve injury. Type III includes type IIIA (recoverable stable type), type IIIB (recoverable unstable type), type IIIC (spinal stenosis type) and type IIID (kyphosis type). There were 14 cases of type I (29.2%), 12 cases of type II (25%), 6 cases of type IIIA (12.5%), 7 cases of type IIIB (14.6%), 6 cases of type IIIC (12.5%), and 3 cases of type IIID (6.2%) in this study. Methods of surgery: The patients of Type I, II, and IIIA were treated with percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP), type IIIB were treated with posterior fixation and fusion, type IIIC were treated with posterior decompression and fixation fusion, and type IIID were treated with posterior osteotomy, orthopedic fixation, and fusion. The VAS and ODI scores were followed up to examine whether the height of the injured vertebra had diminished or secondary kyphosis had occurred, and to detect any improvements in neural function. Results: All patients were followed up for 10–44 months (mean, 20.5 ± 4.5 months). The VAS and ODI scores of all patients were improved compared with those pre-surgery (P < 0.05). Eight cases (16.7%, 8/48) showed loss of vertebral height or secondary kyphosis. At the last follow-up, the AISA Grades of six patients with neural impairment were improved from preoperative Grade C to Grade D (one case), Grade D to Grade E (two cases) and Grade E (three cases). Conclusion: According to the characteristics of different types of Kümmell disease, appropriate clinical treatment strategies can achieve satisfactory curative effects and reduce the occurrence of complications.
Giardiasis and cryptosporidiosis in children and dogs, and the first report of assemblage E in northeastern Brazil
Authors: Harvey Tatiani Vitor , Carvalho Jamille Pinto dos Santos , de Aquino Monally Conceição Costa , Oliveira Bruno César Miranda , de Barros Luiz Daniel , Fehlberg Hllytchaikra Ferraz , Rocha Christiane Maria Barcellos Magalhães da , Albuquerque George Rego
Published: June 2022

Diagnosis is crucial for the control and prevention of diarrheal diseases such as giardiasis and cryptosporidiosis. The aim of this study was to determine the prevalence and genetically characterize isolates of Giardia duodenalis and Cryptosporidium spp. of 143 children and 193 dogs from 40 rural communities in northeastern Brazil. G. duodenalis cysts were concentrated by centrifugal-flotation/sedimentation. Molecular characterization of the isolates was carried out using the loci small subunit ribosomal RNA, beta-giardin, triosephosphate isomerase, and glutamate dehydrogenase for Giardia and with the locus 60-kDa glycoprotein for Cryptosporidium. By parasitological techniques, Giardia was detected in 72/192 (37.5%; 95% CI: 30.6%-44.7%) children and 24/139 (17.3%; 95% CI: 11.4%-24.6%) dogs. By molecular analysis, infection was detected in 60/141 children (42.5%; 95% CI: 34.3%-51.2%) and 26/92 dogs (28.3%; 95% CI: 19.4%-38.6%). The total prevalence of giardiasis, considering the result of parasitological and molecular techniques, was 54.4% (105/193; 95% CI: 47.1%-61.6%) in children and 32.9% (47/143; 95% CI: 25.2%-41.2%) in dogs. Zoonotic assemblages A and B of G. duodenalis were detected in children, and assemblage E of G. duodenalis was detected in one child and two dogs. Cryptosporidium was detected in 36/191 children (25.5%; 95% CI: 13.6%-25.1%) and 4/92 dogs (4.4% 95% CI: 1.2%-10.7%). Cryptosporidium parvum was detected in one children. The parallel use of parasitological and molecular techniques proves to be a more effective strategy for detecting giardiasis in endemic areas. This study is the first report of assemblage E in dogs from northeastern Brazil.
Tendency-and-Attention-Informed Deep Learning for ENSO Forecasts
Authors: Qiao Shen , Zhang Cuicui , Zhang Xuefeng , Zhang Kai , Shi Hao , Li Sheng , Wei Hao
Published: June 2022

Deep learning has been acknowledged as an increasingly important technology for ENSO forecasts. The most cutting-edge deep learning algorithm is developed based on Convolutional Neural Network (CNN), which can achieve a multi-year (about 17-month-lead) forecast and has conquered the ‘spring forecast barrier’ problem. However, this group of methods are still challenged by several critical issues. First, they usually utilize the global sea surface temperature (SST) fields as inputs without considering the specific contributions of variant oceanic regions in ENSO forecasts. Consequently, they cannot effectively investigate the role of the ‘teleconnection’ mechanism among different oceans (Indian, Pacific, and Atlantic Oceans) and different ocean parts (the tropic and non-tropic regions) especially in the forecast of extreme ENSO events. Second, existing methods mainly utilize the discrete monthly SST fields for Deep Learning for ENSO Forecasts ENSO forecasts without investigating the rate-of-changes between adjacent months, which also provides important information to the prediction of variation tendency. To solve these problems, this paper develops a Tendency-and-Attention-Informed Deep Residual Network (TA-DRN) for multi-year ENSO forecasts. The contributions of different oceanic regions can be learned by a spatial attention module while the variation tendency of adjacent previous and current months can be interpreted by the first-and-second order of differences of SST fields. Through informed by these two modules, the performance of TA-DRN can be improved significantly, especially in predicting extreme El Niño and La Niña events.
Heart Rate related to Accuracy of left ventricular strain parameters derived from the single-shot compressed sensing cine CMR images of patients with cardiovascular disease
Authors: Chen Yang , Xu Panpan , Wang Jun , Qian Wen , Liu Wangyan , Zhu Yinsu , Zhou Xiaoyue , Xu Yi , Zhu Xiaomei
Published: June 2022

Objective
To investigate the absolute and relative differences in the left ventricular (LV) global peak strain (GPS) values derived from single-shot compressed sensing (ss-CS) cine cardiac magnetic resonance (CMR) imaging and segmented cine CMR imaging (regarded as gold standard) of patients with cardiovascular disease, and investigate the potential patient-related factors that influence the misestimation of the GPS values from the ss-CS sequence.
Materials and Methods
Sixty-two cardiovascular disease patients with ss-CS cine and standard segmented cine CMR images were enrolled retrospectively. They were classified into different groups based on LV wall thickness and ejection fraction (EF). Absolute and relative differences in the LV GPS were calculated from both cine images. Stepwise multivariable linear regression analysis was performed to determine the patient-related factors that influenced the underestimation of the GPS values from ss-CS cine CMR images.
Results
LV GPS values from the ss-CS cine images were significantly underestimated. Absolute differences in the GPS values derived from both cine images varied significantly between the groups with different wall thickness and EFs (all P < 0.050). However, relative differences in the GPS values were not associated with the LV wall thickness or EF. The stepwise multivariable regression analysis showed that EF and heart rate were both associated with the absolute differences in the GPS values between the two cines (adjusted β-coefficient: 0.244 to 0.485, P < 0.05). Moreover, heart rate was independently associated with the relative differences in the global circumferential strain (GCS) and global longitudinal strain (GLS) values (GCS: β = 0.320, P = 0.011; GLS: β = 0.388, P = 0.002).
Conclusion
EF and heart rate were independently associated with the absolute differences in the LV GPS values. Heart rate was independently associated with the relative differences in the GPS values. Further improvements and standardization are necessary to increase the accuracy of the high-speed CMR imaging techniques in evaluating LV strain parameters.
Protective Effects of Quercetin/Mosses Extract (Homalothecium sericeum Hedw.) Combination on STZ-Induced Diabetic Rats
Authors: YAYINTAS Ozlem TONGUC , OZTURK Samil , Ceyda Latife , DEMİR Nesrin
Published: June 2022

Diabetes mellitus (DM) is the most common chronic endocrine disorder. Although new drugs and administration techniques for diabetes were developed, the nature of complications that occur chronically and reduce patients’ quality of life have not been entirely determined. In our study, 35 male rats were used. A single dose of 40 mg/kg streptozotocin was injected intraperitoneal into 28 rats, and a total of five groups were formed. Diabetes model was performed by applying 40mg/kg STZ. A diabetes model was not established in the subjects in the control and citrate buffer groups with STZ solvent. For treatment purposes, quercetin and moss extract were given by gavage method for three weeks. The liver and pancreas tissues were examined by histochemical and immunohistochemical methods. Immunohistochemically, Ki-67 (proliferation marker), antinuclear factor kappa (NF-κB), and interleukin 6 (IL-6) staining revealed significant differences in inflammation and regeneration in liver and pancreas tissues. In addition, the TUNEL staining method was used to determine apoptosis. Positivity was significant between the treatment and diabetes groups. In addition, it was determined that the agents used as treatment changed serum superoxide dismutase (SOD), malondialdehyde (MDA), C-peptide, insulin, and glucose levels biochemically with antioxidant and anti-apoptotic effects.
The effect of contact conditions on the performance of flexural seismic metasurfaces
Authors: Kaplunov Julius , Prikazchikova Ludmila , Wootton Peter , Nikonov Anatolij , Alzaidi Ahmed SM
Published: June 2022

Plane-strain motion of a flexural seismic metasurface in the form of a regular array of thin Kirchhoff plates attached to the surface of an elastic half-space is analysed. Two types of contact conditions, including simply supported plates and plates moving along horizontal rails are studies. Dispersion of time harmonic waves is investigated both asymptotically and numerically. A major effect of the contact conditions on metasurface behaviour is discovered. In particular, it is shown that frequency band gaps are not the feature of the array composed of simply supported plates. It is also demonstrated that the scaling laws, expressed through geometric and material problem parameters, drastically differ from each other for two considered setups.
Association between serum uric acid and relative handgrip strength compared using metabolic syndrome components
Authors: Yi Dongwon , Lee Min Jin , Khang Ah Reum , Kang Yang Ho
Published: June 2022

Background: This study investigated the association between serum uric acid (UA) and relative handgrip strength (HGS) using metabolic syndrome components.Methods: We analyzed the data of 5,579 Korean adults aged ≥20 years (2,486 men and 3,093 women) who participated in the Korea National Health and Nutrition Examination Survey VII (2018).Results: Among women, relative HGS was significantly lower in participants with hyperuricemia (1.61 ± 0.03) than in those without (1.92 ± 0.01) and was significantly decreased in the highest quartile (4Q:1.74 ± 0.02) of serum UA compared with that in the lowest quartile (1Q:1.96 ± 0.02). Among men, relative HGS was lower in participants with hyperuricemia (3.09 ± 0.03 vs. 3.15 ± 0.02) and decreased in the highest quartiles (4Q:3.08 ± 0.03) of serum UA compared with that in the lowest quartile (1Q:3.14 ± 0.03); however, these results were not statistically significant. In age- and multivariate-adjusted analyses in men, relative HGS was significantly lower in 4Q compared with that in 1Q in model 1 (adjusted for age), but there were no significant differences in model 2 (adjusted for age, body mass index, and waist circumference) and model 3 (adjusted for age, body mass index, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, triglycerides and high-density lipoprotein cholesterol). Meanwhile in women, relative HGS was significantly decreased in 4Q compared with that in 1Q in all models.Conclusions: An inverse correlation was observed between serum UA levels and relative HGS. These results were particularly significant in women, and their significance was maintained even after adjusting for age and metabolic syndrome components.
Cardiac rehabilitation in coronary artery bypass grafting patients: Effect of 8-week of moderate-intensity continuous training versus high-intensity interval training
Authors: Shafie Neda , Kordi Negin , Gadruni Keivan , SalehFard Ziba , NazarAli Parvaneh
Published: June 2022

Purpose
The aim of the present study was to investigate the effects of traditional moderate-intensity rehabilitation training and interval training on some angiogenesis factors in coronary artery bypass graft (CABG) patients.
Methods
Thirty CABG patients (mean age ± SD, 55 ± 3 years) were randomly assigned to one of three groups: high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) or the control group. After the initial assessments, eligible patients in the experimental groups (HIIT and MICT) performed exercise training for 8 weeks, while the control group did not. Angiogenesis and angiostatic indices, including pro-adrenomedullin (pro-ADM), basic fibroblast growth factor (bFGF), and endostatin, were then measured.
Results
The results showed no significant difference between pro-ADM in the HIIT and MICT groups (P = 0.99), but a significant difference was found between MICT and the control group and between HIIT and the control group (P = 0.001). There is also no significant difference between the bFGF levels in the HIIT and MICT training groups (P = 1.00), but the changes in this factor between the training groups and the control group were significant (P = 0.001). There was a significant difference between the levels of endostatin in all three groups.
Conclusion
Two methods of cardiac rehabilitation (HIIT and MICT) may be useful for the recovery of patients with coronary artery bypass grafting. This improvement manifested itself in changes in angiogenesis and angiostatic indices in this study. However, more extensive studies are needed to investigate the effects of these two types of rehabilitation programs on other indicators of angiogenesis and angiostatic.
False positive analysis of machine-learning based sepsis prediction
Authors: Basu Debraj , Maharjan Jenish , Allen Angier , Thapa Rahul , Attwood Misty M , Hurtado Myrna , Iqbal Zohora , Hoffman Jana
Published: June 2022

Background
Despite the emergence of several promising machine learning models for prediction of patients at risk of sepsis, investigation of factors that contribute to false positive rates has not been performed. Here, we conducted a false positive analysis to determine the sources of false alerts and examine a mitigation methodology for reduction of false positive rates in sepsis prediction.
Methods
Analysis of false positive predictions from our sepsis prediction model was conducted and patient populations were stratified by underlying conditions that contribute to false positives. Sensitivity and specificity results for each subpopulation were calculated while adjusting the initial adjustment threshold. An optimal threshold was applied to an entire test set to observe the effect on performance.
Results
Certain underlying conditions mimic sepsis and contribute to false positive rates. The optimal threshold adjustment for the whole population resulted in greater reductions of false positives than true positives.
Conclusions
An optimal threshold adjustment to a whole population based on specific patient populations stratified by underlying conditions reduces the number of false positive cases while increasing the specificity and positive predictive value and still maintaining high sensitivity.
Evaluation of incidence and risk factors of acute kidney injury development in hospitalized COVID 19 patients; A case-control study
Authors: AL-Dammad Zakaria , AL-Halawat Anas , Alchallah Mhd Obai , AL-Dammad Farida , Assaf Nihad saeed
Published: June 2022

BackgroundAcute kidney injury (AKI) is common among patients hospitalized with COVID-19 and associated with worse prognosis. The aim of this study was to investigate the epidemiology, risk factors and outcomes of AKI in hospitalized patients in Damascus hospital.Design A case control study conducted in Damascus hospital.Methods The study reviewed 299 medical records of hospitalized covid 19 patients between 2021 to 2021 after, a self-administered forms used to fill demographical, comorbid conditions, vital signs, laboratory studies, the goal is to gauge the risk factors for having acute kidney injury in covid-19 and the effect on prognosis and mortality. The study was performed in accordance with the principles of the Declaration of Syrian private university Research Ethics Committee.ResultThrough this study prevalence rate of AKI were 145 (48.5%) in hospitalized patients, the median age was (67+-12.3) years in AKI patients. hypertension, diabetes, and chronic kidney disease, have increased the risk of having a new onset AKI, this study shows that AKI frequently complicates the course of COVID-19 hospitalizations and is associated with increased severity of illness, and poor prognosis.ConclusionAKI frequently complicates the course of COVID-19 hospitalizations and is associated with increased severity of illness, and poor prognosis. We demonstrate an independent association between some factors and the development of AKI and mortality, early detection of comorbidities and renal complications is essential to improve the outcomes of COVID-19 patients.
Truncated Human IRF-1 (1-233) protein shows neutral transcriptional effect on expression of Bax, survivin, Bcl2 and cyclin D1 genes in HEK293T cell line
Authors: Prakash Krishna , Haque Prof. Rizwanul , Mishra Santosh Kumar
Published: June 2022

We generated the truncated IRF-1(1-233 amino acids), lacks total C-terminal domains, like the Transactivation domain, instability domain, Multifunctional domains. We used semi-nested PCR technique followed by gene cloning in E.coli and observed profound expression of mutant GST-IRF-1 protein (~ 52 kDa) in 12.5% SDS PAGE. We ectopically expressed truncated mutant version of IRF-1 and wild version of IRF-1 in Human Embryonic Kidney cell line HEK293 and HEK293T. We observed truncated version of IRF-1 was unable to show any effect on the expression of chromosomal genes, like Bcl2, surviving and cyclin D1. In addition to that truncated mutant IRF-1 did not influence the growth and proliferation of HEK293 and HEK293T cells that were also confirmed by MTT assay. Although both wild and truncated version of IRF-1 showed similar DNA binding activity by EMSA technique yet, both shows differential transcription activation activity. Hence, these findings demonstrate that the region 234–325 amino acids in human IRF-1 is important for the expression of Bax, Survivin, Bcl2, and Cyclin D genes in the present experimental model system.
WITHDRAWN: Effects of structure, purity, and alignment factors on the heat conduction properties of nanostructured materials comprising single-walled carbon nanotubes
Authors: Chen Junjie
Published: June 2022

The increasing popularity of single-walled carbon nanotubes has created a demand for greater scientific understanding of the characteristics of thermal transport in nanostructured materials. However, the effects of structure, purity, and alignment factors on the specific heat capacity and thermal conductivity of single-walled carbon nanotubes are still poorly understood. The effects of structure, purity, and alignment factors on the heat conduction properties of single-walled carbon nanotubes were investigated by using the nonequilibrium molecular dynamics method. The specific heat capacity and thermal conductivity of carbon nanotube-based materials were determined to understand the characteristics of thermal transport in the nanostructured materials. The effect of single-walled carbon nanotube loading on the heat conduction properties of carbon nanotube-based polymer composites was investigated. The results indicated that single-walled carbon nanotubes are very efficient at conducting heat. The structure, purity, and alignment factors play a fundamentally important role in determining the heat conduction properties of single-walled carbon nanotubes. The difference in specific heat capacity between graphene and single-walled carbon nanotubes is larger at lower temperatures but becomes very small at higher temperatures. The purity strongly affects the heat conduction properties of single-walled carbon nanotubes, whereas the effect of alignment on the thermal conductivity is considerable. The lattice thermal conductivity of carbon nanotube-based materials first increases and then decreases with temperature. Single-walled carbon nanotube reinforced epoxy composites are able to achieve significant improvements in thermal properties at much lower loadings. A significant improvement in heat conduction properties can be achieved when single-walled carbon nanotubes serve as thermal reinforcements for epoxy composite systems with further promise of multifunctionality.
The complete mitochondrial genome of critically endangered Hangul (Cervus hanglu hanglu) and its comparison with the other red deer
Authors: Yadav Prabhaker , Kumar Ajit , Yadav Neha , Gupta Sandeep Kumar
Published: June 2022

Background: Hangul (Cervus hanglu hanglu) or Kashmiri stag belongs to the family Cervidae and is the only surviving red deer in the Indian subcontinent. Its complete mitogenome sequence is lacking in the open database for further phylogenetic inferences.Methods and results: We sequenced and characterized the first complete mitogenome of Hangul, which was 16,354 bp in length. It was compared with other red deer subspecies. We observed eight pairs of overlapping genes and 15 intergenic spacers in between the mitochondrial regions. Relative synonymous codon usage (RSCU) for the 13 PCGs of Hangul consisted of 3597 codons (excluding stop codons). We observed a highest frequency for leucine (11.75%) and the lowest for tryptophan amino acid (1.12%) in 13 PCGs of Hangul. All the tRNA genes showed a typical secondary cloverleaf arrangement, excluding tRNA-Ser in which dihydrouridine arm did not form a stable structure. Conclusions: The Bayesian inference phylogenetic tree indicated that Hangul clustered within the Tarim deer group (C. h. yarkandensis) and closed to C. e. hippelaphus, which formed the western clade. Besides, the subspecies of C. nippon and C. canadensis clustered together and formed an eastern clade. The finding was supported by the mean pairwise genetic distance based on both complete mitogenome and 13 PCGs. The comparative study of the Hangul mitogenome with other red deer provides crucial information for understanding the evolutionary relationships. It offers a valuable resource for conserving this critically endangered cervid with a limited distribution range.
Persönlichkeitsrechtliche Aspekte des Erstellens audiovisueller Aufnahmen von Polizeieinsätzen durch Privatpersonen im öffentlichen Raum
Authors: Stückelberger Benjamin
Published: June 2022

Die audiovisuelle Aufzeichnung von Polizeieinsätzen durch Privatpersonen – etwa mittels Smartphones – wirft zahlreiche rechtliche Fragen auf. Der vorliegende Beitrag diskutiert die Zulässigkeit des Erstellens solcher Aufnahmen im öffentlichen Raum unter persönlichkeitsrechtlichen Gesichtspunkten und thematisiert dazu die Interessen der aufnahmeerstellenden Person, der Polizist:innen und allfällig involvierter Drittpersonen unter grundrechtlichen, zivilrechtlichen und strafrechtlichen Blickwinkeln.

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L’enregistrement audiovisuel d’interventions policières par des particuliers — par exemple au moyen de smartphones — soulève de nombreuses questions juridiques. Le présent article discute de l’admissibilité de tels enregistrements dans l’espace public du point de vue du droit de la personnalité. Pour ce faire, les intérêts de la personne qui enregistre, des agent·e·s de police et des tiers éventuellement impliqués sont examinés sous l’angle des droits fondamentaux, du droit civil et du droit pénal.
Rényi entropies and negative central charges in non-Hermitian quantum systems
Authors: Tu Yi-Ting , Tzeng Yu-Chin , Chang Po-Yao
Published: June 2022

Quantum entanglement is one essential element to characterize many-body quantum systems. However, the entanglement measures are mostly discussed in Hermitian systems.
Here, we propose a natural extension of entanglement and Rényi entropies to non-Hermitian quantum systems.
There have been other proposals for the computation of these quantities, which are distinct from what is proposed in the current paper.
We demonstrate the proposed entanglement quantities which are referred to as
generic entanglement and Rényi entropies. These quantities capture the desired entanglement properties in
non-Hermitian critical systems, where the low-energy properties are governed by the non-unitary conformal field theories (CFTs).
We find excellent agreement between the numerical extrapolation of the negative central charges from the generic entanglement/Rényi entropy
and the non-unitary CFT prediction.
Furthermore, we apply the generic entanglement/Rényi entropy to symmetry-protected topological phases with
non-Hermitian perturbations.
We find the generic n-th Rényi entropy
captures the expected entanglement property,
whereas the traditional Rényi entropy can exhibit unnatural singularities due to its improper definition.
SETTING THE STAGE FOR THE SUN: Interrogations of performance of flicker
Authors: Blum Sonja
Published: June 2022

Flicker is a coordinated beat which can be superimposed on the brain’s alpha rhythm, through a flickering light source, and is associated with hallucinatory or visionary states of mind. In this experimental piece, I weave ideas and performance into a poetic image and text piece proposing some hypotheses and questions surrounding the relationship of moving bodies, the sun, and eureka moments of visions and dreams of new worlds.
Experimental Music and the Political: Performativity in the art of John Cage
Authors: Lomnitz Ricardo
Published: June 2022

This text aims to explore some of the philosophical inquiries that arise from experimental music, focusing on the following question: How is music, without words, capable of producing and enacting political thought? Focusing on John Cage's art an exploration of the performativity of music is proposed, understanding performativity both as the effects that music has on its audience, and its “theatrical” quality. Cage’s work is especially well suited for this objective, inasmuch as it is based upon both an explicit desire to modify the perception of its audience, and an interest in developing an art form that is closer to “theatre” (in a broad sense). As Alejandro L. Madrid has suggested, using performativity as a lens of analysis to study music shifts the question “What is music?” to “What does music do?” and “What does it allow people to do?” Through a revision and discussion of Cage’s art pieces, the author of this text argues that Cage’s work supposes a destabilization of traditional notions and roles, allowing people to listen to their surroundings with greater attention and pleasure (thus questioning Eurocentric and anthropocentric conceptual and sensorial frameworks inherited from the past), and to perform atypical social relations of an anarchist nature.
On the Caesura in Dance: Reading Black Waters as history at a standstill
Authors: Kittlaus Santhia Velasco
Published: June 2022

The art of dance, as a practice expressed in the body language of the dancer, addresses our bodily existence by resembling it. It has the narrative power to make us, as audiences who inhabit bodies ourselves, rediscover the body as a condition of being human that we all share. This illumination can lead us to look at each other’s bodies with more care. With this premise in mind, I call for a moment in the perception of dance that creates an awareness of the social references enacted in the performance. In my consideration, I focus on dance as evocative of imaginative thought, its stillness as dialectical, in which dance takes on an interrupting quality, and ask: How does the perception of a dancing body influence us as spectators in our thinking about the bodies of others? I read Phoenix Dance Theatre’s performance Black Waters (2020) as a representation of colonial history that sheds light on the visibility of Black identities and how they are read through the White gaze. This article particularises dance as a possibility of encounter that enhances decolonial thinking.
Performance Philosophy 7(2) (2022): Imagining the open
Authors: Cull Ó Maoilearca Laura , Daddario Will , Damian Martin Diana , Schmidt Theron
Published: June 2022

This is the editorial for Performance Philosophy 7(2) (2022)
Correlation analysis of mechanical properties of dilated packer cylinder
Authors: Wang Lin , Zhang Tao , Zhou Xiaojun
Published: June 2022

The expanding packer is a commonly used packer, which is widely used in the process of oil and gas production. Taking the most commonly used K344 hydraulic expansion packer as the research object, using SolidWorks and ANSYS Workbench software to establish a two-dimensional finite element model of the K344 packer rubber cylinder, carry out stress analysis on the packer rubber cylinder, and obtain the packer rubber cylinder Von Mises stress and contact stress nephograms. The research results show that when the packer is in the working state of internal pressure of 20.0 MPa, the stress level of the upper and lower rubber cylinder seats is the highest, and the maximum Mises stress is 54.86 MPa; the stress level at both ends of the rubber cylinder is the highest, up to 43.465 MPa, and the strain energy density on both sides is the largest; when the packer is in the working state, the shoulder deformation is the largest, with the increase of the pressure, the deformation trend slows down, and the strain energy density has a linear relationship with the working pressure. The obtained results can provide a theoretical basis for the structural design of the expandable packer.
The influence of regenerant with different dosages on the performance of aged SBS modified asphalt
Authors: Wang Quanlei , Xu Zhoucong , Wu Jie , Chen Fei , Wang Huoming
Published: June 2022

In asphalt pavement thermal regeneration, incorporation of regenerant can restore the properties of aged SBS modified asphalt, but the effect of regenerant on the recovery of aged asphalt and the dosage of regenerant are not clear. In this study, experiments are carried to determine the effect of regenerant on the performance of aged SBS modified asphalt and the appropriate dose. Accelerated aging test is conducted by rolling thin film oven test (RTFOT) at different times. Then, different doses of regenerant (2 %, 4 %, 6 %, 8 %, 10 %, 12 %) are added to the specimens before and after aging, and test its technical indexes such as penetration, softening point and ductility to analyze the effect of regenerant on the properties of aged asphalt. The results show that: with the increase of the amount of regenerating agent, the aging asphalt performance indexes are restored, the softening point of regenerated asphalt is reduced, and the ductility and needle penetration are increased. Based on the analysis of the relationship between the aging time of SBS modified asphalt and the amount of regenerant, interpolation fitting is carried out to obtain the formula for the best amount of regenerant, so as to determine the best regenerant dosage for aged asphalt mixes in actual engineering applications.
Instability threshold analysis and optimization of a rotor system considering the Alford force
Authors: Fu Yao , Wang Fei
Published: June 2022

Under certain circumstances, the Alford force might induce instability of the rotor system. The mechanism and influence factors of the Alford force induced instability were analyzed with the Jeffcott rotor. Then a method for calculating the instability threshold was proposed. Finally, the optimization model of a high-speed micro-turbojet engine was established to optimize the instability threshold. The results show that the anisotropy of support stiffness and the damping ratio can both improve the threshold of instability. The instability threshold can be greatly improved by optimizing bearing stiffness and diameter of the rotor system.
Design of Ka band substrate integrated waveguide slot traveling wave array antenna
Authors: Shi Long , Wang Weizhi , Zhao Yichang , Yang Jingang
Published: June 2022

Aiming at the requirements of Missile Radio Fuze Antenna with low sidelobe, narrow beam and specific directional pattern, a design method of Ka band substrate integrated waveguide (SIW) slot traveling wave array antenna is proposed. Based on the slot theory of SIW, the slot parameters and the excitation amplitude of Taylor linear array elements are calculated by MATLAB, and then the slot parameters and the excitation amplitude of array elements are optimized by Ansoft HFSS electromagnetic simulation software to realize the design of Ka band SIW slot traveling wave array antenna. The simulation results show that the Ka band SIW slot quasi traveling wave array antenna has a working frequency of 34.5 GHz, a gain of 14.2 dB, an E-plane beam width of 8° and a beam inclination of 20°, which can meet the requirements of missile radio fuze.
3D CFD simulation and analysis of transient flow in a water pipeline
Authors: Cao Yun , Zhou Ling , Ou Chuanqi , Fang Haoyu , Liu Deyou
Published: June 2022

A three-dimensional (3D) computational fluid dynamics (CFD) approach is developed to elaborate the water-hammer pipe flow and 3D detailed dynamic characteristics of a closing ball valve. The proposed CFD approach considers the water compressibility and the viscous sublayer, which are sometimes neglected in previous studies. Comparisons of the CFD results, the measured pressures and the one-dimensional results, demonstrate that the current 3D CFD approach better reproduces the experimental pressure oscillations while helping to visualize the associated physical processes and to further explore the 3D transient characteristics. The mean velocity distributions in the radial direction significantly change as the pipe transient progresses, which is closely associated with transient shear stress. Mean velocity variations at the valve during the closing process undergo three distinct stages: slight change, then drastic reduction, and finally slowing down. Head loss coefficient and discharge coefficient of the valve change as the valve closing time shortens.