bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementing a combined Delphi and Focus Group qualitative methodology in Nexus research designs—The case of the WEFE Nexus in Apokoronas, Crete
Authors: Canessa Carolin , Vavvos Andreas , Triliva Sofia , Kafkalas Iosif , Vrachioli Maria , Sauer Johannes
Published: July 2022

In recent years, researchers and policymakers have emphasised the importance of understanding the complex relationships between Water, Energy, Food and Ecosystems (WEFE). The primary reason for capturing these complexities is to understand how decisions made in the water, food and energy sectors can affect one another. Crucially, biodiversity and ecosystem services (E) play a mediating role in these relationships by making material and non-material contributions to all other sectors (W, E, F). The Nexus approach has been widely used for capturing these interdependencies and identifying opportunities for increasing efficiency, reducing trade-offs and building synergies for sustainable resource use across the WEFE nodes. One challenge in using this framework is the need to harmonise the technical and managerial dimensions of the WEFE interlinkages with the perceptions and priorities of local populations directly involved in the use and management of resources. This paper presents a methodological framework that seeks to integrate the perspectives of experts, practitioners and local stakeholders on the WEFE Nexus through the combined application of the Delphi and Focus Group methods. In this paper, the municipality of Apokoronas in Crete, Greece has served as the case in point. The combined framework allowed us to explore the Nexus understanding at the local level and was instrumental in the identification of initiatives for more integrated resource management. The triangulation of results captured the differences in priorities between practitioners and the local community at large, but also, more specifically, it pointed to discrepancies within groups and across WEFE sectors. The outcomes of this paper demonstrate that awareness and learning play a central role in Nexus actions to overcome conflicts and perceived inequalities, and to internalise solutions. The inclusion of the ecosystems node in the traditional WEF Nexus encouraged participants to contemplate the pivotal role of ecosystems in supporting the rest of the WEF sectors.
Efficient realization of quantum primitives for Shor’s algorithm using PennyLane library
Authors: Antipov A. V. , Kiktenko E. O. , Fedorov A. K.
Published: July 2022

Efficient realization of quantum algorithms is among main challenges on the way towards practical quantum computing. Various libraries and frameworks for quantum software engineering have been developed. Here we present a software package containing implementations of various quantum gates and well-known quantum algorithms using PennyLane library. Additoinally, we used a simplified technique for decomposition of algorithms into a set of gates which are native for trapped-ion quantum processor and realized this technique using PennyLane library. The decomposition is used to analyze resources required for an execution of Shor’s algorithm on the level of native operations of trapped-ion quantum computer. Our original contribution is the derivation of coefficients needed for implementation of the decomposition. Templates within the package include all required elements from the quantum part of Shor’s algorithm, specifically, efficient modular exponentiation and quantum Fourier transform that can be realized for an arbitrary number of qubits specified by a user. All the qubit operations are decomposed into elementary gates realized in PennyLane library. Templates from the developed package can be used as qubit-operations when defining a QNode.
The effect of Cyclophilin D depletion on liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy
Authors: Daradics Noemi , Horvath Gergo , Tretter Laszlo , Paal Agnes , Fulop Andras , Budai Andras , Szijarto Attila
Published: July 2022

Aim

Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) is a modification of two-stage hepatectomy profitable for patients with inoperable hepatic tumors by standard techniques. Unfortunately, initially poor postoperative outcome was associated with ALPPS, in which mitochondrial dysfunction played an essential role. Inhibition of cyclophilins has been already proposed to be efficient as a mitochondrial therapy in liver diseases. To investigate the effect of Cyclophilin D (CypD) depletion on mitochondrial function, biogenesis and liver regeneration following ALPPS a CypD knockout (KO) mice model was created.

Methods

Male wild type (WT) (n = 30) and CypD KO (n = 30) mice underwent ALPPS procedure. Animals were terminated pre-operatively and 24, 48, 72 or 168 h after the operation. Mitochondrial functional studies and proteomic analysis were performed. Regeneration rate and mitotic activity were assessed.

Results

The CypD KO group displayed improved mitochondrial function, as both ATP production (P < 0.001) and oxygen consumption (P < 0.05) were increased compared to the WT group. The level of mitochondrial biogenesis coordinator peroxisome proliferator-activated receptor γ co-activator 1-α (PGC1-α) was also elevated in the CypD KO group (P < 0.001), which resulted in the induction of the mitochondrial oxidative phosphorylation system. Liver growth increased in the CypD KO group compared to the WT group (P < 0.001).

Conclusions

Our study demonstrates the beneficial effect of CypD depletion on the mitochondrial vulnerability following ALPPS. Based on our results we propose that CypD inhibition should be further investigated as a possible mitochondrial therapy following ALPPS.
Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57
Authors: Majerciak Vladimir , Alvarado-Hernandez Beatriz , Lobanov Alexei , Cam Maggie , Zheng Zhi-Ming
Published: July 2022

RNA splicing plays an essential role in the expression of eukaryotic genes. We previously showed that KSHV ORF57 is a viral splicing factor promoting viral lytic gene expression. In this report, we compared the splicing profile of viral RNAs in BCBL-1 cells carrying a wild-type (WT) versus the cells containing an ORF57 knock-out (57KO) KSHV genome during viral lytic infection. Our analyses of viral RNA splice junctions from RNA-seq identified 269 RNA splicing events in the WT and 255 in the 57KO genome, including the splicing events spanning large parts of the viral genome and the production of vIRF4 circRNAs. No circRNA was detectable from the PAN region. We found that the 57KO alters the RNA splicing efficiency of targeted viral RNAs. Two most susceptible RNAs to ORF57 splicing regulation are the K15 RNA with eight exons and seven introns and the bicistronic RNA encoding both viral thymidylate synthase (ORF70) and membrane-associated E3-ubiquitin ligase (K3). ORF57 inhibits splicing of both K15 introns 1 and 2. ORF70/K3 RNA bears two introns, of which the first intron is within the ORF70 coding region as an alternative intron and the second intron in the intergenic region between the ORF70 and K3 as a constitutive intron. In the WT cells expressing ORF57, most ORF70/K3 transcripts retain the first intron to maintain an intact ORF70 coding region. In contrast, in the 57KO cells, the first intron is substantially spliced out. Using a minigene comprising of ORF70/K3 locus, we further confirmed ORF57 regulation of ORF70/K3 RNA splicing, independently of other viral factors. By monitoring protein expression, we showed that ORF57-mediated retention of the first intron leads to the expression of full-length ORF70 protein. The absence of ORF57 promotes the first intron splicing and expression of K3 protein. Altogether, we conclude that ORF57 regulates alternative splicing of ORF70/K3 bicistronic RNA to control K3-mediated immune evasion and ORF70 participation of viral DNA replication in viral lytic infection.
Geomorphological and stratigraphic analyses at the archaeological excavation in the Megapark, Nyíregyháza-Oros
Authors: Buró Botond , Jakab Attila , Lóki József
Published: July 2022

The aim of our morphological and stratigraphic investigations at the archaeological excavation in the area of the Megapark at Nyíregyháza–Oros is to make the reconstruction of the Aeolian development of the study area more accurate. The excavation is located between the rem-nants of two abandoned river beds in a wind-blown sand area near the crossing of main roads 4 and 41 East of Nyíregyháza–Oros. Eight bore-holes were drilled in the site of the excavation. The cores were sampled in order to perform the sedimentological analysis of the penetrated strata. Strata of the sand dune are divided by a fossil soil horizon in which a cemetery from the age of the Hungarian conquest was found. Underneath the cemetery findings from the imperial age and urn graves from the Bronze Age were excavated. This suggests that wind-blown sand covered the soil horizon in a thickness of 1-1.5 m by the age of the conquest. The 3-4 m thick wind-blown sand excavated from the findings indicates sand accumulation following the 10th century.
Versões impressas no papel e na memória: Abrigo de Menores, novembro de 1956
Authors: Nunes Eduardo Silveira Netto
Published: July 2022

A partir de uma denúncia do jornal “A Verdade”, de Florianópolis, em de novembro de 1956, sobre o Abrigo de Menores do Estado de Santa Catarina, encontrada no arquivo dos Irmãos Maristas, administradores do Abrigo na época, desenvolvemos uma narrativa que apresenta o transcurso do processo de pesquisa envolvendo o tema da denúncia, e como diferentes versões a respeito do episódio foram sendo constituídas em processo de disputa, às vezes silencioso, sobre qual teria maior legitimidade enquanto expressão de uma memória que falasse pelos Abrigados a respeito do ocorrido. Nessa disputa analisamos os Jornais da cidade, os Maristas, e como se desenvolveu um diálogo cruzado permitindo-se perceber como a imprensa e os sujeitos sociais “interagem” no processo social dinâmico. E, através de entrevistas com ex-Abrigados contemporâneos ao evento, e que participaram do mesmo, pois “fugiram” do Abrigo e foram até a redação do Jornal cobrar retratação, identificamos que, na trama histórica, a as crianças, se fazem sujeitos ativos dos processos sociais.
A Arqueologia do Saber de Michel Foucault
Authors: Ragusa Pedro
Published: July 2022

O objetivo deste artigo é mostrar como a pesquisa arqueológica de Michel Foucault foi desenvolvida a partir da composição de um eixo teórico-metodológico híbrido, o qual, serviu de aporte para a prática de suas histórias arqueológicas nos anos sessenta. O hibridismo teórico-metodológico da arqueologia do saber foi explorado nesse artigo a partir de um percurso teórico que coloca em discussão a complexa relação entre a epistemologia francesa e o estruturalismo, ambos articulados pelo filósofo através da problemática sobre a descrição dos saberes. Dessa maneira, o artigo procura localizar a singularidade do método de Michel Foucault intitulado arqueologia do saber e oferecer uma contribuição para um importante debate originário nos sessenta sobre a participação de Foucault no movimento estruturalista. De fato, o filósofo adota procedimentos estruturalistas ao delimitar a noção de episteme como estrutura para os saberes, mas realiza uma análise estrutural através de uma problemática da pesquisa posta pela epistemologia francesa e através da descontinuidade histórica.
Supporting the capacities and knowledge of small-holder farmers in Kenya for sustainable agricultural futures: A Citizen Science pilot project
Authors: Davies Matthew , Haklay Muki , Kiprutto Timothy , Laws Megan , Lewis Jerome , Lunn-Rockliffe Samuel , McGlade Jaqueline , Moreu Marcos , Yano Andrew , Kipkorir Wilson
Published: July 2022

Sub-Saharan Africa is often presented as the continent most vulnerable to climatic change with major repercussions for food systems. Coupled with high rates of population growth and existing nutritional deficiencies, the need to enhance food production across the continent is thus seen as a major global imperative. We argue here, however, that current models of agricultural development in Eastern Africa often marginalise critical small-holder knowledge from the process of future agricultural design due to a lack of a methodological tools for engagement. This paper addresses this by outlining a potential means to capture and share locally produced agronomic information on a large scale. We report on a ‘Citizen Science’ pilot study that worked with smallholder farmers in Elgeyo-Marakwet County, western Kenya, to co-design a mobile application using the well-developed
Sapelli platform that easily allows farmers to identify, record and geolocate cropping patterns and challenges at multiple stages in the agricultural calendar using their own understandings. The pilot project demonstrated the technical and epistemological benefits of co-design, the abilities of smallholder farmers to co-design and use smartphone applications, and the potential for such technology to produce and share valuable agricultural and ecological knowledge in real time. Proof-of-concept data illustrates opportunities to spatially and temporally track and respond to challenges related to climate, crop disease and pests. Such work expounds how smallholder farmers are a source of largely untapped ecological and agronomic expert knowledge that can, and should, be harnessed to address issues of future agricultural resilience and food system sustainability.
DIFFERENCES IN TEAR SECRETION BEFORE AND AFTER PHACOEMULSIFICATION SURGERY USING SCHIRMER I TESTS
Authors: Daryosta Raditya Pradana , Saubig Arnila Novitasari , Cahyono Maharani , Nugroho Trilaksana
Published: July 2022

Background: Cataract is a serious problem in the world because it is the biggest cause of blindness in the world. Cataract healing can only be done with operative measures, one of them is phacoemulsification. The phacoemulsification technique is the latest operative technique for cataract healing but both conventional techniques or phacoemulsification techniques can cause a decrease in tear secretion after cataract surgery. The reduction in tear secretion can be evaluated using the Schirmer I test. In this study an analysis of differences in tear secretion before and after phacoemulsification surgery.Aims: Knowing, comparing, and analyzing the differences in tear secretion before and after phacoemulsification surgery using the Schirmer I test.Methods: 22 cataract eyes consisting of 15 patients who will undergo phacoemulsification surgery were collected by consecutive sampling at the Sultan Agung Eye Center, Sultan Agung Hospital, Semarang from August to September 2019, examined using the Schirmer I test. After the data was collected, data analyzed with Wilcoxon rank test.Results: A total of 15 cataract patients consisting of 10 female patients and 5 male patients with a total of 22 eye samples. The average tear secretion before and after phacoemulsification surgery was 12.77 ± 2.74 mm and 11.00 ± 1.95 mm. Data were tested with the Wilcoxon rank test, p = 0,000 (p <0.05) which showed a difference in average tear secretion before and after phacoemulsification.Conclusion: There are differences in tear secretion before and after phacoemulsification surgery.
THE EFFECT OF PLYOMETRICS TRAINING ON LEG MUSCLE STRENGTH OF MEDICAL STUDENTS IN DIPONEGORO UNIVERSITY
Authors: Ismail Nur Azzahra Permata Putri , Basyar Edwin , Indraswari Darmawati Ayu , Marijo Marijo
Published: July 2022

Introduction : Strength is the ability to excert force, which can resist external resistance and its purpose as a basis for human movements. Strength also can be a standard for measuring someone’s performance. Plyometrics training known as an exercise that can increased muscle strength. Great muscle strength can lead to great muscle endurance so that the person will become healthier and will not get tired easily. However, there’s still no further study that measured leg muscle strenght on medical students after given plyometrics training treatment. Methods : Intervention of the study was plyometrics training for 6 weeks. This study was a quasi-experimental with pre-test (before training), middle-test (after four weeks training), and post-test (after six weeks training). The subjects were 28 (15 to 25-year old) male medical students of Diponegoro University divided into 2 groups with 14 samples for each group: control group and treatment group. Muscle strength were measured by leg dynamometer. The results were analyzed using SPSS. Results : The muscle strength which measured by leg dynamometer improved among subjects who did plyometrics training. The significant results (P = <0,05) found on middle-test and post-test proved that plyometrics training affects the enhancement of leg muscle strength. Conclusions : Plyometrics training for 6 weeks proved to increase leg muscle strength of medical students in Diponegoro University.Keywords: Plyometrics Training, Strength, Leg Dynamometer
Dynamic and Steady Model Development of Two-Chamber Batch Microbial Fuel Cell (MFC)
Authors: Harimawan Ardiyan
Published: July 2022

As an alternative source of renewable energy that has piqued researchers’ interest, Microbial Fuel Cell’s (MFC) limitation of low power density requires further development. Various factors affect the performance, but performing all will be costly and time-consuming. Through a combination of dynamic and steady-state mathematical model modified from past research, effect of microbe types towards dynamic biofilm formation and stead-state OCV can be observed, followed by steady-state simulation to determine maximum power density and its’ corresponding voltage. Similarity with previous research has been observed, with maximum OCV of 838.93 mV achieved by heterotrophic biomass in 75-100 hours with biofilm thickness of 2.087 x 10-4 m, while generating maximum power density of 2050.12 mW//m2 and voltage of 408.16 mV. Lowest OCV value of 838.76 mV was observed in C. sporogenes in 450-475 hours with a biofilm thickness of 2.079 x 10-4 m, while the lowest value of maximum power density was observed in anaerobic microbial communities at 8.48 mW/m2 with voltage of 90.43 mV. Furthermore, it has been observed that variations with higher  and lower  results in higher stead-state OCV in the shortest amount of time, while increasing power density and its’ corresponding voltage. @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536869121 1107305727 33554432 0 415 0;}@font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4; mso-font-charset:0; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:-469750017 -1073732485 9 0 511 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-fareast-font-family:Calibri; mso-hansi-font-family:Calibri; mso-ansi-language:IN; mso-fareast-language:IN;}div.WordSection1 {page:WordSection1;}
The Effect of Variation of Raw Material Ratio on Hydrogel Based on K-Carrageean - Acrylamide as a Carrier of Ammonium Nitrate Fertilizer
Authors: Laksono Hendrawan , Kurniati Mersi , Sari Yessie Widya , Winarti Christina
Published: July 2022

Hydrogels based on natural polymers such as carrageenan are currently being developed to improve efficiency in agriculture. By enriching hydrogels with fertilizers, they will be released slowly into the soil. Enrichment of fertilizers on carrageenan-based hydrogels was carried out and analyzed with the response of swelling ability, gel fraction value of grafting degree, to the hydrogel's ability to release the fertilizer trapped in it. Carrageenan is used because its use as a natural polymer has not been widely explored, especially in the non-food sector. The results showed that the average swelling value of carrageenan-based hydrogel to ammonium nitrate solution ranged from 750.00% - 1,633.33%. The gel fraction values obtained ranged from 74.06% to 87.51%, and the degree of grafting ranged from 85.33% to 93.59%. These values indicate a relatively high degree of tissue density and grafting of acrylamide monomer on carrageenan, which means that the carrageenan:AAm based hydrogel has strong mechanical properties. The ability to release ammonium nitrate samples from the hydrogel carrageenan-based has a value ranging from 8.86% to 44.92% in five days of observation. Interpretation of the test results, the best ratio of carrageenan:AAm is 1:1, due to its relatively low release value but still has good swelling and mechanical properties.Keywords: Hydrogel; Carrageenan; Acrilamyde; Fertilizer release
Characteristics of Edible Film Made from Pectin of Papaya Peel
Authors: Halim Yuniwaty , Darmawan Carinna Ruth
Published: July 2022

Papaya (Carica papaya L.) peel contains a considerable amount of pectin, high molecular weight polysaccharides that can be used in edible film making due to its ability to form gels. However, edible film from pectin usually has poor moisture barrier properties. Therefore, pectin is generally combined with glycerol as plasticizer and starch. This research aimed to utilize pectin from papaya peel with the addition of corn starch in edible film making to determine the characteristics of pectin from papaya peel and the effect of pectin and corn starch concentration on edible film characteristics. Pectin extracted from papaya peel was classified as low methoxyl pectin (LMP). The pectin was then utilized in edible films making together with corn starch addition. Two factors were used in this research, which included pectin amount (0.75 g, 1.0 g, 1.25 g) and corn starch concentration (40%, 50%, 60%, based on pectin). The selected edible films formulation was an edible film made from a pectin amount of 1 g with 50% corn starch (based on pectin weight). This formulation showed low water vapor transmission rate (WVTR) of 3.447±0.270 g.mm/m2/hour, a moderate tensile strength of 1.3121±0.0720 MPa, a moderate elongation percentage of 9.42±0.08%, and a thickness of 0.11±0.01 mm.Keywords: corn starch; edible films; papaya peel; pectin
Seagrass meadows in the Greek Seas: presence, abundance and spatial distribution
Authors: Panayotidis Panayiotis , Papathanasiou Vasillis , Gerakaris Vasileios , Fakiris Elias , Orfanidis Sotiris , Papatheodorou Georgios , Kosmidou Maria , Georgiou Nikos , Drakopoulou Vivi , Loukaidi Valia
Published: July 2022

Combined use of optical (satellite imagery) and acoustic (sidescan sonar) remote sensing techniques, as well as in situ methodologies (visual census; SCUBA diving, Towed Underwater Cameras, and Remotely Operated Vehicles) was employed to map the spatial distribution of seagrass habitats in the coastal waters of the Greek territory. Seagrass meadows were recorded over approximately 70% of the Greek coastline (Eastern Ionian, Aegean and Levantine Seas), and their surface area exceeded 2749.07 km2. Posidonia oceanica is clearly the dominant seagrass species in Greek Seas, covering the vast majority of seabed at depths between the shoreline and 25–30 m (or deeper in insular areas), followed by the species Cymodocea nodosa, Zostera noltei, and Halophila stipulacea, that are not widely distributed but are locally abundant in specific areas. Habitat suitability in terms of the of the seabed that is available for the growth of seagrass meadows (i.e., the spatial extent of coastal areas between the shoreline and the isobath of 20 m) and the seawater clarity conditions are highlighted as the critical factors for the formation of well-structured and extensive meadows. The results of this study are of great importance and usefulness for the effective management and conservation of valuable marine ecosystems and are given in the form of an openly accessible shapefile.
Redegewalt und doppelte Übersetzung
Authors: Weidner Daniel
Published: July 2022

Der Beitrag untersucht sprachliche und bildliche Darstellungen der Pfingstgeschichte als Urszene, das heißt als Inszenierung des Anfangs der christlichen Kirche und als Paradigma eines christlichen Verständnisses von Sprache. Er zeigt, wie diese Gründung mit dem Phänomen der Übersetzung, aber auch mit den Grenzen der Sprache (der »Zungenrede«) verbunden ist sowie wie diese Gründung in der Heilsgeschichte Israels situiert und durch den Jüngerkreis eine politische Ordnung instituiert wird. In diesem Rahmen erscheint auch der Geist als wesentlicher Bestandteil christlichen Sprechens sowie die erste spezifisch christliche Sprechhandlung: die Predigt des Petrus.
Entwichene Sprache
Authors: Haustein Jörg
Published: July 2022

Als pseudo-sprachliche Artikulation mag Zungenrede der Semantik entweichen, als zentrales theologisches Konstrukt der Pfingstbewegung ist sie jedoch mit Bedeutung überladen. Dieser Beitrag stellt die Diskussion um pfingstliche Glossolalie aus historischer, theologischer und sprachphilosophischer Perspektive vor und zeigt, wie das Ringen um eine »Nichtsprache« für das Verständnis von Theologie und Sprache fruchtbar sein kann.
Psychagogische Schockrhetorik für Zermürbte
Authors: Becker Matthias
Published: July 2022

Der Aufsatz widmet sich am Paradebeispiel der deliberativen Rhetorik des Hebräerbriefes der Frage, wie und zu welchem Zweck in neutestamentlichen Texten Bedrohungen sprachlich konstruiert und kommuniziert werden. Im modifizierenden Anschluss an theoretische Konzepte der Sozial- und Geisteswissenschaften werden sechs Sinndimensionen von Bedrohungskommunikation untersucht: die sachliche, soziale, zeitliche, emotionale, religiöse und die paränetische Sinndimension. Im Ergebnis zeigt sich, dass der als autoritätsbewusster Redner auftretende Verfasser mit seinen rhetorischen Drohgebärden die psychagogische Intention verfolgt, durch das mehrdimensionale Szenario eines drohenden Heilsverlusts den Glaubensabfall der Adressaten zu verhindern. Bedrohungskommunikation erscheint in diesem Licht folglich auch als eine Form sprachlicher Machtausübung.
D-dimer: old dogmas, new (COVID-19) tricks
Authors: Lippi Giuseppe , Mullier François , Favaloro Emmanuel J.
Published: July 2022

D-dimer is a fibrin degradation product encompassing multiple cross-linked D domains and/or E domains present in the original fibrinogen molecule, whose generation is only theoretically possible when hemostasis and fibrinolysis pathways are concomitantly activated. D-dimer measurement has now become a pillar in the diagnosis/exclusion and prognostication of venous thromboembolism (VTE) and disseminated intravascular coagulation (DIC), when incorporated into validated clinical algorithms and especially using age-adjusted diagnostic thresholds. Although emerging evidence is also supporting its use for predicting the duration of anticoagulant therapy in certain categories of patients, the spectrum of clinical applications is constantly expanding beyond traditional thrombotic pathologies to the diagnosis of acute aortic dissection, acute intestinal ischemia and cerebral venous thrombosis among others, embracing also clinical management of coronavirus disease 2019 (COVID-19). Recent findings attest that D-dimer elevations are commonplace in patients with severe acute respiratory syndrome (SARS-CoV-2) infection (especially in those with thrombosis), its value predicts the clinical severity (up to death) of COVID-19 and remains more frequently increased in COVID-19 patients with post-discharge clinical sequelae. Further, D-dimer-based anticoagulant escalation may be associated with a lower risk of death in patients with severe SARS-CoV-2 infection and, finally, D-dimer elevation post-COVID-19 vaccination mirrors an increased risk of developing vaccine-induced thrombocytopenia and thrombosis (VITT).
Black Feminist Organizing and Caribbean Cyberfeminisms in Puerto Rico
Authors: Stephens Miari Taina
Published: July 2022

This article centers Black feminist organizing in Puerto Rico, highlighting social media as a tool for racial and gender justice. Collaboration between Puerto Rican feminist organizations on social media platforms amplifies their on-the-ground work and demands. Mapping Caribbean Cyberfeminisms (2016) theorizes Caribbean cyberfeminisms as “knowledge-producing spaces of political thought and action” online by Caribbean feminists. I argue that through content creation and curation, reposting and sharing, commenting and captioning, broadcasting live, Black feminist collectives, organizations and projects in Puerto Rico use digital and virtual technologies to extend their Black feminist organizing and collaboration, building a Caribbean cyberfeminist network in the process.
Novel non-stop variant of the NR0B1 gene in two siblings with adrenal hypoplasia congenita
Authors: Ota Tomoko , Katsumata Noriyuki , Naiki Yasuhiro , Horikawa Reiko
Published: July 2022

Objectives

Mutations in the dosage-sensitive sex reversal-AHC critical region on the X chromosome, gene 1 (DAX-1, officially NR0B1), cause X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HHG). Salt-losing adrenal insufficiency usually occurs during the neonatal period or early childhood. We report a novel non-stop variant of NR0B1 in two siblings and their unusual clinical course.

Case presentation

The proband was a boy who presented with an unusual form of AHC with neonatal onset of growth failure and mild salt loss, but without cutaneous pigmentation or plasma ACTH elevation. His 4-year-old elder brother had been growing healthily, but carried an AHC diagnosis. A non-stop variant of NR0B1 (p.*471K) was demonstrated in the patients and their mother.

Conclusions

We identified a novel non-stop variant of NR0B1 in two siblings. Mild salt loss associated with hyperkalemia is a crucial diagnostic clue for AHC, even without apparent symptoms of glucocorticoid deficiency.
Negative photoresponse in Ti3C2T
x
MXene monolayers
Authors: Vorobeva Nataliia S. , Bagheri Saman , Torres Angel , Sinitskii Alexander
Published: July 2022

Two-dimensional transition metal carbides, nitrides, and carbonitrides, collectively known as MXenes, are finding numerous applications in many different areas, including optoelectronics and photonics, but there is limited information about their intrinsic photoresponse. In this study, we investigated the visible and near-infrared range photoresponse of Ti3C2T
x
, the most popular MXene material to date. The electrical measurements were performed on devices based on individual monolayer Ti3C2T
x
MXene flakes, which were characterized by a variety of microscopic and spectroscopic methods. For MXene devices with different electrode layouts, the current reproducibly decreased under illumination with either white light or lasers with different wavelengths in the visible and near-infrared region, thus demonstrating a negative photoresponse. The understanding of the intrinsic photoresponse of Ti3C2T
x
should facilitate the optoelectronic and photonic applications of MXenes.
Hierarchical visible-infrared-microwave scattering surfaces for multispectral camouflage
Authors: Huang Yun , Zhu Yining , Qin Bing , Zhou Yiwei , Qin Rui , Ghosh Pintu , Qiu Min , Li Qiang
Published: July 2022

Multispectral camouflage, especially for the infrared-microwave range, is an essential technology for the safety of facilities, vehicles, and humans. So far, it has been realized mainly by high infrared specular reflection and high microwave absorption. However, external infrared sources can expose the target through specular reflection; also, the heat production from microwave absorption can increase the infrared radiation. This work proposes a multispectral camouflage scheme based on hierarchical visible-infrared-microwave scattering surfaces to address these issues. The proposed device exhibits: (1) low infrared emissivity (ε
8–14 μm = 0.17) and low infrared specular reflectivity (R

s

8–14 μm = 0.13), maintaining low infrared radiation and capability to overcome the presence of an external infrared source simultaneously; (2) high scattering in microwave range, with −10 dB radar cross section reduction bandwidth of 8–13 GHz, simultaneously achieving microwave camouflage and reducing the heat production; (3) tunability of color for visible camouflage. This work proposes a method to control scattering over visible-infrared-microwave bands, thereby introducing a new design paradigm for modern camouflage technology.
Chemical thermodynamics of ternary M-An(VI)-CO3 system (M = Mg, Ca, Sr, and Ba)
Authors: Jo Yongheum , Lee Jun-Yeop , Yun Jong-Il
Published: July 2022

This review provides an overview of the chemical thermodynamics on ternary earth-alkaline metal-actinyl-tricarbonate systems (i.e., M-AnO2-CO3, M = Mg, Ca, Sr, and Ba) and discusses the aqueous complexation and dissolution/precipitation equilibrium for these ternary aqueous systems. The aqueous ternary U(VI) carbonate species are remarkably predominant in the U(VI) speciation under natural environmental conditions at ambient temperature and moderate ionic strength condition, while the omnipresence, according to recent studies, would be hindered by an increase in temperature and ionic strength. With respect to the ternary solid U(VI) carbonate phases, most of the previously reported data have been focused on physical properties and thus a notable lack of available data on chemical thermodynamic properties, i.e., solubility product constant, has been identified. Nevertheless, substantial influences of these ternary M-AnO2-CO3 systems on the aqueous speciation and the solubility limiting phase under the natural environmental condition are taken into account according to the thermodynamic calculation. The authors point out that the completeness of the chemical thermodynamic model for predicting the chemical behavior of actinides in nature can be further improved on the basis of a sufficient understanding of ternary M-AnO2-CO3 systems.
Continuous Tracking of Task Parameters Tunes Reaching Control Online
Authors: De Comite Antoine , Crevecoeur Frédéric , Lefèvre Philippe
Published: July 2022

A hallmark of human reaching movements is that they are appropriately tuned to the task goal and to the environmental context. This was demonstrated by the way humans flexibly respond to mechanical and visual perturbations that happen during movement. Furthermore, it was previously showed that the properties of goal-directed control can change within a movement, following abrupt changes in the goal structure. Such online adjustment was characterized by a modulation of feedback gains following switches in target shape. However, it remains unknown whether the underlying mechanism merely switches between prespecified policies, or whether it results from continuous and potentially dynamic adjustments. Here, we address this question by investigating participants’ feedback control strategies in presence of various changes in target width during reaching. More specifically, we studied whether the feedback responses to mechanical perturbations were sensitive to the rate of change in target width, which would be inconsistent with the hypothesis of a single, discrete switch. Based on movement kinematics and surface EMG data, we observed a modulation of feedback response clearly dependent on dynamical changes in target width. Together, our results demonstrate a continuous and online transformation of task-related parameters into suitable control policies.
Navigating the Statistical Minefield of Model Selection and Clustering in Neuroscience
Authors: Király Bálint , Hangya Balázs
Published: July 2022

Model selection is often implicit: when performing an ANOVA, one assumes that the normal distribution is a good model of the data; fitting a tuning curve implies that an additive and a multiplicative scaler describes the behavior of the neuron; even calculating an average implicitly assumes that the data were sampled from a distribution that has a finite first statistical moment: the mean. Model selection may be explicit, when the aim is to test whether one model provides a better description of the data than a competing one. As a special case, clustering algorithms identify groups with similar properties within the data. They are widely used from spike sorting to cell type identification to gene expression analysis. We discuss model selection and clustering techniques from a statistician’s point of view, revealing the assumptions behind, and the logic that governs the various approaches. We also showcase important neuroscience applications and provide suggestions how neuroscientists could put model selection algorithms to best use as well as what mistakes should be avoided.
Hydropolitics in the Black Sea: From Political Competition to Environmental Cooperation?
Authors: Altingoz Mehmet , Ali Saleem H. , Vladich Helena
Published: July 2022

Many major rivers discharge into the Black Sea and bring major nutrient pollution, leading to rapid plant growth and eutrophication impacts in the ecosystem. Yet, the Black Sea cannot replace the lost oxygen during this process due to its natural conditions, such as low salinity, low density, very limited connection to larger seas and oceans, and low vertical and horizontal circulation. This resulted in about 90% of the sea to have anaerobic conditions and caused serious consequences on almost every aspect of life for basin countries. After the dissolution of the Soviet Union in 1991, the riparian countries that recharge the sea began cooperating to address the pollution problem despite numerous international conflicts they had had with each other. Some progress has been made so far, but tense diplomatic relations persist. Little improvement of international relations has taken place in the region due to environmental cooperation. This study seeks, based on a range of interviews with stakeholders and archival research, to understand how this environmental cooperation initiated and survived despite the diplomatic impasse. Moreover, it seeks ways to improve the effectiveness of the cooperation and translate this cooperation to improvement of the international relations among the riparians. As part of the solution, this study suggests giving more authority to the local level institutions handling day-to-day management of the Black Sea. This research is of special interest for government workers employed at units that handle international water management, policymakers focusing on environmental policies, and members of academia conducting relevant research.
El cerebro humano y la enseñanza de la gramática
Authors: Madrigal López Damaris
Published: July 2022

Este artículo discute acerca de las estrategias de mediación que se han empleado para la didáctica de la gramática tanto en el nivel de la educación secundaria como en el de la superior. La Neurolingüística ha aprovechado el progreso de los avances médicos en Neurología para comprender mejor cómo funciona el cerebro humano en todos lo relativo a la capacidad comunicativa de los hablantes, no solo en cuanto a sus capacidades de producción y escucha, sino que principalmente a sus capacidades de construcción e interpretación de mensajes; ámbito que se relaciona más con la lógica y las partes del cerebro vinculadas con ella. De tal manera que al pretender mediar en el proceso de aprendizaje de la gramática, si se induce a los estudiantes a fragmentar en partes un texto o una oración, se le está solicitando que emplee su hemisferio izquierdo, pero, cuando se le solicita que identifique los componentes sintácticos a través de preguntas del tipo ¿quién?, ¿qué? y ¿a quién? para los componentes de la oración, se le induce a error, porque este tipo de preguntas lleva implícito el concepto de animidad, que el cerebro derecho reconoce bien, de manera que no logra dar respuestas no animadas a preguntas que demandan una respuesta animada. De ahí que haya una idea constante por responder con sujetos animados y complementos indirectos animados, mientras que se tiende a considerar los complementos directos como inanimados, lo que limita el análisis y la comprensión de textos.
Usabilidade do WhatsApp
Authors: Nunes Sergio da Costa , Aragon Rosane
Published: July 2022

Este trabalho apresenta um estudo qualitativo, desenvolvido em uma turma de alunos de curso superior, da área de informática, objetivando explorar as potencialidades do WhatsApp como interface pedagógica para os processos de ensino e aprendizagem da disciplina de Sistemas de Informações. Para tanto, avaliou-se a usabilidade do WhatsApp com a aplicação de questionário compatível com o SUS – System Usability Scale, postado no Google Forms. O questionário SUS foi aplicado após a turma utilizar o WhatsApp para responder, de forma colaborativa, questões relativas ao conteúdo de ERP – Enterprise Resource Planning da disciplina. Foram criados quatro grupos de cinco alunos e após a consecução do trabalho cada participante do grupo respondeu ao questionário SUS. O Score SUS de 80,9 possibilitou verificar que o WhatsApp atendeu, de forma significativa, as exigências de usabilidade para a realização do trabalho, apontando-o como uma ferramenta viável pedagogicamente, nesta pesquisa.
Palavras-chave: WhatsApp; SUS; ensino; aprendizagem; usabilidade.
Impact of the first COVID–19 lockdown on the lifestyle of elementary school children
Authors: Bartha K.O. , Csengeri L. , Lichthammer A. , Erdélyi A. , Kubányi J. , Szűcs Zs.
Published: July 2022

COVID-19 lockdown affects people's daily routine and has an impact on their lifestyle. Recent studies documented associations between body weight changes and children's lifestyle during social isolation. Childhood obesity is associated with a higher risk of COVID-19 severity and mortality. Our aim was to assess the effects of lockdown due to the COVID-19 pandemic on children's sleep, screen time, physical activity, and eating habits. 387 parents of five elementary school students between 16 and 26 June 2020 were interviewed through an online questionnaire. Physical activity level decreased (63.8%), sleep (60.9%) and screen (5.64 ± 3.05 h/day) times and food intake (39.8%) increased. 80.6% of parents reported changes in children's diet: increased consumption of fruits and vegetables (32.4%), breakfast (15.5%), water and sugar-free beverages (17.6%), snacks (40.4%), sugary drinks (9.9%) was observed. Body weight increased in 44.4% of children. The results of the survey conducted under GYERE®-Children's Health Program are in line with the international literature findings: body weight change during the quarantine is significantly associated with food intake, snacking, sugary drinks, and we also found association with fruit and vegetable consumption and lack of breakfast. Effective strategies and electronic health interventions are needed to prevent sedentary lifestyle and obesity during lockdown.
Nosology of behavioral addictions: Intersections with philosophy of psychiatry •
Authors: Stein Dan J. , Lochner Christine
Published: July 2022

Writing in this journal, Brand and colleagues have proposed criteria for other specified disorders due to addictive behaviors. Their proposal intersects with key debates in philosophy of psychiatry, including how best to define mental disorders, to validate them, and to optimize their meta-structure. Review of these debates in the context of behavioral addictions suggests several conclusions. First, these debates involve “essentially contested” constructs that require ongoing consideration and judgment. Second, the complexity of psychopathology suggests multiple legitimate approaches to delineating traits and explicating mechanisms. Third, in optimizing meta-structure, non-psychobiological considerations are crucial - the overlapping public mental health approach to addictive disorders is paramount.
Agency of the Self and the Uncertain Nature of the Beloved in Persian Love Mysticism: Earthly, Ethereal, Masculine, or Feminine?
Authors: Vali-Zadeh Mahdieh
Published: July 2022

It seems that the controversies over the nature of the beloved in classical Persian mystic poetry (also known as Sufi poetry) as an earthly or ethereal phenomenon would never end. Those in favor of the celestial reading of it consider their counterparts to be narrow-minded. The adherents of terrestrial love, though, see mystical readings dogmatic and outdated, prevailed by traditionalists. The topic gets even more complicated when one takes into account the attitudes in the medieval Muslim world toward pederasty, shāhid-bāzī, on the one hand, and the Divine Feminine /Masculine Beloved, on the other hand, and, thus, the gender of this beloved. The present article explores the beloved in Persian classical mystical poetry via five different but related approaches: historical, philosophical, translational and comparative, linguistic and poetic, and, ultimately, developmental. The study concludes that an essentialist reading of the beloved in Persian love mystic poetry would create numerous problems, and that the spirit of Persian classical poetry in this regard is the spirit of uncertainty with a certain purpose: it is the manifestation of the self-poet’s agency, choosing one’s object of desire without explicitly revealing it and, thus, living one’s own life of choice without fearing the threads of religious fundamentalism.
Tecnologia educacional para primigestas: estudo quase experimental
Authors: Cassiano Alexandra do Nascimento , Teixeira Elizabeth , de Menezes Rejane Maria Paiva
Published: July 2022

RESUMO Objetivo: Analisar a influência de uma tecnologia educacional sobre o conhecimento de primigestas acerca dos sinais de trabalho de parto e de risco obstétrico. Método: Estudo quase experimental do tipo antes e depois, não randomizado e não concorrente, realizado com 90 primigestas. Para análise dos dados foi aplicada estatística descritiva, McNemar e t Student. O projeto foi submetido e aprovado pelo Comitê de Ética em Pesquisa em 2020. Resultados: O perfil das gestantes correspondeu a mulheres com idade média de 23 anos, pardas, que vivenciam uma união estável e com média de 10 anos de escolaridade. Metade das gestantes estavam no terceiro trimestre gestacional e realizavam o pré-natal de risco habitual. Apenas 12,22% das participantes relataram ter acesso a informações sobre a temática. A análise dos dados evidenciou diferença significativa no número de acertos das questões, antes e depois da visualização do vídeo animado, principalmente nas perguntas relacionadas aos sinais de trabalho de parto, bolsa d’águas e mobilograma. Conclusão: A tecnologia educacional tem influência positiva sobre o conhecimento das primigestas acerca dos sinais de trabalho de parto e de risco obstétrico.