bluuebunny/crossref_metadata_2025 huggingface dataset:
Noninvasive Assessment of Gastric Emptying by Near-Infrared Fluorescence Reflectance Imaging in Mice: Pharmacological Validation with Tegaserod, Cisapride, and Clonidine
Authors: Gremlich Hans-Ulrich , Martínez Vicente , Kneuer Rainer , Kinzy Willy , Weber Eckhard , Pfannkuche Hans-Juergen , Rudin Markus
Published: March 2018

Noninvasive near-infrared fluorescence reflectance imaging (FRI) is an in vivo technique to assess physiological and molecular processes in the intact organism. Here we describe a method to assess gastric emptying in mice. TentaGel™ beads with covalently bound cyanine dye (Cy5.5) conjugates as fluorescent probe were administered by oral gavage. The amount of intragastric beads/label was derived from the fluorescence signal intensity measured in a region of interest corresponding to the mouse stomach. The FRI signal intensity decreased as a function of time reflecting gastric emptying. In control mice, the gastric half-emptying time was in agreement with literature data. Pharmacological modulation of gastric motility allowed the evaluation of the sensitivity of the FRI-based method. Gastric emptying was either stimulated or inhibited by treatment with the 5-HT4 receptor agonists tegaserod (Zelnorm®) and cisapride or the α2-receptor agonist clonidine, respectively. Tegaserod and cisapride dose-dependently accelerated gastric emptying. In contrast, clonidine dose-dependently delayed gastric emptying. In conclusion, FRI using fluorescently labeled beads allows the reliable determination of gastric emptying as well as the assessment of pharmacological interventions. The technique thus offers the potential to characterize molecular targets and pathways involved in physiological regulation and pharmacological modulation of gastric emptying.
Imaging Gene Expression in Regional Brain Ischemia in Vivo with a Targeted [111In]-Antisense Radiopharmaceutical
Authors: Suzuki Toyofumi , Zhang Yun , Zhang Yu-feng , Schlachetzki Felix , Pardridge William M.
Published: March 2018

The gene encoding glial fibrillary acidic protein (GFAP) is down-regulated 24 hr after reversible brain ischemia, such as with a middle cerebral artery occlusion (MCAO). The in vivo imaging of decreased GFAP gene expression in cerebral ischemia was examined in the present studies using a targeted peptide nucleic acid (PNA), which was labeled with 111In, and which hybridized to nucleotides 20–37 of the rat GFAP mRNA. The PNA was monobiotinylated, and was attached to a monoclonal antibody (MAb) to the transferrin receptor (TfR) via a biotin–streptavidin linkage. The TfR MAb enables trans-membrane transport of the PNA antisense radiopharmaceutical from blood to the cytosol of brain cells. The decreased GFAP gene expression at 24 hr after a 1-hr reversible MCAO was confirmed by immunocytochemistry. The [111In]-labeled PNA–MAb conjugate was administered intravenously to anesthetized rats at 24 hr after the 1-hr reversible MCAO, and the brain uptake of the targeted antisense imaging agent was decreased relative to brain regions outside of the infarct zone. These studies provide evidence that decreased expression of a target gene in brain can be imaged in vivo with a sequence-specific PNA, provided the antisense radiopharmaceutical is delivered across cell membranes with a receptor-specific targeting agent.
Methotrexate-Induced Accumulation of Fluorescent Annexin V in Collagen-Induced Arthritis
Authors: Wunder Andreas , Schellenberger Eyk , Mahmood Umar , Bogdanov Alexei , Müller-Ladner Ulf , Weissleder Ralph , Josephson Lee
Published: March 2018

We examined the accumulation of Cy5.5-labeled annexin V in the paws of mice with and without collagen-induced arthritis, with and without methotrexate (MTX) treatment, by near-infrared fluorescence imaging. Fluorescence reflectance imaging (FRI) of paws was performed 48 hr after MTX injection and at 10 min and 3 hr after the injection of Cy5.5-annexin V (1 nmol dye per mouse). With arthritic paws, MTX treatment caused a 7-fold increase in fluorescence intensity compared with the paws of untreated mice and a 4-fold increase compared to nonarthritic paws of MTX-treated mice ( p < .001 each). Tissue samples of paws were examined histologically for Cy5.5 fluorescence and by TUNEL staining for apoptosis. Cy5.5-annexin V was seen in the hyperplastic synovia of MTX-treated mice, and TUNEL staining for apoptosis showed apoptotic cells in the hyperplastic synovia. Monitoring the uptake of Cy5.5-annexin V in arthritic paws by FRI provided a method of assessing a response to MTX, a response that was readily quantitated with simple instrumentation and that occurred before conventional measurements of treatment response.
Imaging Multidrug Resistance P-glycoprotein Transport Function Using MicroPET with Technetium-94m-Sestamibi
Authors: Bigott Heather M. , Prior Julie L. , Piwnica-Worms David R. , Welch Michael J.
Published: March 2018

The best characterized mechanism of multidrug resistance (MDR) in cancer involves the MDR1 efflux transporter P-glycoprotein (Pgp). The positron-emitting radiotracer hexakis (2-methoxyisobutylisonitrile)-94mTc (94mTc-MIBI) was synthesized and validated in cell transport studies as a substrate for MDR1 Pgp. In vivo small-scale PET imaging and biodistribution studies of mdr1a/1b (−/−) gene deleted and wild-type mice demonstrated the use of 94mTc-MIBI to detect Pgp function. The reversal effect of a Pgp modulator was shown in tissue distribution studies of KB 3–1 (Pgp-) and KB 8–5 (Pgp+) tumor-bearing nude mice. The current 94mTc-MIBI experiments parallel previous studies employing 99mTc-MIBI, showing essentially identical performance of the two technetium radiotracers and providing biological validation of 94mTc-MIBI for PET imaging of multidrug resistance.
Visualizing Drug Efficacy In Vivo
Authors: Zhang Weisheng , Chen Min , West David B. , Purchio Anthony F.
Published: March 2018

Many enzymes are therapeutic targets for drug discovery, whereas other enzymes are important for understanding drug metabolism and pharmacokinetics during compound testing in animals. Testing of drug efficacy and metabolism in an animal model requires the measurement of disease endpoints as well as assays of enzyme activity in specific tissues at selected time points during treatment. This requires the removal of tissue and biochemical assays. Techniques to noninvasively assess drug effects on enzyme activity using imaging technology would facilitate understanding of drug efficacy, pharmacokinetics, and drug metabolism. Using a commercially available cytochrome P−450 3A substrate whose oxidized product is a luciferase substrate, we show for the first time that cytochrome P−450 enzyme activity can be measured in vivo in real time by bioluminescent imaging. This imaging approach could be applicable to study drug effects on therapeutic target enzymes, as well as drug metabolism enzymes.
The Chronology of al-Qāḍī l-Nuʿmān’s Works
Authors: Poonawala Ismail K.
Published: March 2018

A chronology of an author’s works is necessary for understanding his or her intellectual evolution. Al-Qāḍī l-Nuʿmān wrote numerous books on diverse disciplines, such as jurisprudence, history, traditions of the Messenger of God and the Ismāʿīlī imams, biographies of the Fāṭimid caliph-imams, refutations of the Sunnī schools of law, and allegorical interpretation of the Qurʾān and the šarīʿa. The chronology of al-Qāḍī l-Nuʿmān’s corpus, which consists of more than fifty titles, is based primarily on pieces of evidence in his extant works. The sequence of al-Qāḍī l-Nuʿmān’s legal works suggests that The Pillars of Islam (Daʿāʾim al-islām), compiled under the directions of al-Muʿizz around 349/960, was his crowning achievement after serving the first four Fāṭimid caliph-imams since 313/925. In fact, al-Qāḍī l-Nuʿmān began and completed his first work Kitāb al-Īḍāḥ, a massive collection of legal traditions transmitted on the authority of the family of the Prophet, while he was still serving al-Mahdī (r. 297/909-322/934). The chronology further reveals that after composing The Pillars of Islam, al-Qāḍī l-Nuʿmān devoted his energies to the explication of the major Ismāʿīlī theological doctrine, namely the theory of taʾwīl (hermeneutics). In his Asās al-taʾwīl, he justifies the twin concepts of taʾwīl and bāṭin (the inner, hidden, esoteric meaning behind the literal wording of sacred texts)—from a jurist’s viewpoint—and argues that these concepts are firmly grounded in the foundational texts of Islam, viz., the Qurʾān and the Hadiths of the Prophet.
Between History and Exegesis: the Origins and Transformation of the Story of Muḥammad and Zaynab bt Ǧaḥš
Authors: Görke Andreas
Published: March 2018

This article examines the origins of the story of the Prophet Muḥammad’s controversial marriage with Zaynab bt Ǧaḥš as well as its transformation and reinterpretation through the centuries. The fact that the story features in different genres of Islamic literature as well as in non-Muslim sources allows for a reconstruction of how and where the story emerged, how it spread and to what extent it was transformed over time. In the course of this reconstruction, the article critically assesses different approaches to the historicity of reports on the life of Muḥammad. With its analysis of later Muslim sources, it also illustrates different strategies of reinterpreting and recasting traditions and shows how societal change and different ideologies influenced the interpretation of the story.
Two new species of the Rhopalopsole magnicerca group (Plecoptera: Leuctridae) from China
Authors: MO RAORAO , WANG GUOQUAN , YANG DING , LI WEIHAI
Published: March 2018

Two leuctrid species of the Rhopalopsole magnicerca group are described as new, R. brevicula sp. nov. and R. jizushana sp. nov. from the Guangxi Autonomous Region of southern China, bordering Vietnam and Yunnan Province of southwestern China, respectively. The new species are compared with related taxa.
A remarkable new species of Zoraptera, Zorotypus asymmetristernum sp. n., from Kenya (Insecta, Zoraptera, Zorotypidae)
Authors: MASHIMO YUTA , MATSUMURA YOKO , BEUTEL ROLF G. , NJOROGE LABAN , MACHIDA RYUICHIRO
Published: March 2018

A new species of order Zoraptera, Zorotypus asymmetristernum Mashimo, n. sp., is described from Kakamega, Kenya, with its major diagnostic features and characteristics of the egg described and illustrated. The new species represents the sixth zorapteran species from the Afrotropic ecozone. A brief discussion on vestigial eye spots of apteron individuals and a key to the species of the Afrotropic ecozone are provided.
Report on the Fourth International Conference on School and Popular Meteorological and Oceanographic Education
Authors: Moran Joseph M. , Smith David R. , Snow John T.
Published: March 2018

The Fourth International Conference on School and Popular Meteorological and Oceanographic Education was held 22–26 July 1996 in Edinburgh, Scotland. Conference attendees included 125 educators, meteorologists, oceanographers, and government officials representing 19 nations. The themes of the conference were the roles of meteorology and oceanography in science education and the benefits derived from improved environmental awareness and scientific literacy, particularly weather awareness, meteorological literacy, and understanding of the ocean. Formal presentations, workshops, poster sessions, and demonstrations provided information on programs for teacher enhancement, computer-aided instruction, and classroom access to real-time weather information through the World Wide Web.
A study of neighbour selection strategies for POI recommendation in LBSNs
Authors: Rios Carlos , Schiaffino Silvia , Godoy Daniela
Published: March 2018

Location-based recommender systems (LBRSs) are gaining importance with the proliferation of location-based services provided by mobile devices as well as user-generated content in social networks. Collaborative approaches for recommendation rely on the opinions of like-minded people, so-called neighbours, for prediction. Thus, an adequate selection of such neighbours becomes essential for achieving good prediction results. The aim of this work is to explore different strategies to select neighbours in the context of a collaborative filtering–based recommender system for POI (places of interest) recommendations. Whereas standard methods are based on user similarity to delimit a neighbourhood, in this work several strategies are proposed based on direct social relationships and geographical information extracted from location-based social networks (LBSNs). The impact of the different strategies proposed has been evaluated and compared against the traditional collaborative filtering approach using a dataset from a popular network as Foursquare. In general terms, the proposed strategies for selecting neighbours based on the different elements available in a LBSN achieve better results than the traditional collaborative filtering approach. Our findings can be helpful both to researchers in the recommender systems area and to recommender system developers in the context of LBSNs, since they can take into account our results to design and provide more effective services considering the huge amount of knowledge produced in LBSNs.
Guidelines of the International Headache Society for controlled trials of preventive treatment of chronic migraine in adults
Authors: Tassorelli Cristina , Diener Hans-Christoph , Dodick David W , Silberstein Stephen D , Lipton Richard B , Ashina Messoud , Becker Werner J , Ferrari Michel D , Goadsby Peter J , Pozo-Rosich Patricia , Wang Shuu-Jiun ,   for the International Headache Society Clinical Trials Standing Committee
Published: March 2018

Background

Quality clinical trials form an essential part of the evidence base for the treatment of headache disorders. In 1991, the International Headache Society Clinical Trials Standing Committee developed and published the first edition of the Guidelines for Controlled Trials of Drugs in Migraine. In 2008, the Committee published the first specific guidelines on chronic migraine. Subsequent advances in drug, device, and biologicals development, as well as novel trial designs, have created a need for a revision of the chronic migraine guidelines.

Objective

The present update is intended to optimize the design of controlled trials of preventive treatment of chronic migraine in adults, and its recommendations do not apply to trials in children or adolescents.
What constitutes meaningful engagement for patients and families as partners on research teams?
Authors: Black Agnes , Strain Kimberly , Wallsworth Christine , Charlton Sara-Grey , Chang Wilma , McNamee Kate , Hamilton Clayon
Published: March 2018

Objective

There is growing emphasis on health care organizations to ensure that lay people are meaningfully engaged as partners on research teams. Our aim was to explore the perspectives of patients, family members and informal caregivers who have been involved on health care research teams in Canada and elicit their recommendations for meaningful engagement.

Methods

We conducted a qualitative study guided by thematic analysis of transcripts of focus groups and interviews of 19 experienced patient research partners in Canada.

Results

We identified four main themes: research environment, expectations, support and value, which highlight participants’ combined perspectives on important factors to ensure their engagement in research is meaningful.

Conclusions

Our findings add to the evolving evidence base on the perspectives of lay people involved in health care research and their recommendations for research leaders on meaningful engagement. Our study suggests that research leaders should provide a welcoming research environment, outline appropriate expectations for patient research partners on research teams, support patient research partners’ engagement in projects and recognize the value patient research partners bring to health research.
A review and update of the Health of the Nation Outcome Scales (HoNOS)
Authors: James Mick , Painter Jon , Buckingham Bill , Stewart Malcolm W.
Published: March 2018

Aims and method

The Health of the Nation Outcome Scales (HoNOS) and its older adults’ version (HoNOS 65+) have been used widely for 20 years, but their glossaries have not been revised to reflect clinicians' experiences or changes in service delivery. The Royal College of Psychiatrists convened an international advisory board, with UK, Australian and New Zealand expertise, to identify desirable amendments. The aim was to improve rater experience by removing ambiguity and inconsistency in the glossary rather than more radical revision.

Results

Changes proposed to the HoNOS are reported. HoNOS 65+ changes will be reported separately. Based on the views and experience of the countries involved, a series of amendments were identified.

Clinical implications

While effective clinician training remains critically important, these revisions aim to improve intra- and interrater reliability and improve validity. Next steps will depend on feedback from HoNOS users. Reliability and validity testing will depend on funding.

Declaration of interest

None.
Organization of Dynamic Social Interaction in the Process of Innovative Activity
Authors: Масленникова Надежда , Maslennikova Nadezhda , Масленников И. , Maslennikov I.
Published: March 2018

The purpose of the article is to compare the classical principles of personnel management of a multifunctional team to maintain harmonious social and labor relations in the innovation process. Studies of various models show the necessity to consider the team of innovators as the most effective form of innovation activity, and the principles of Follett M. are most suitable for organizing dynamic social interaction in a team aimed at increasing the effectiveness of an innovative project. Implementation of collective responsibility for an innovative project that is carried out by a multifunctional team strengthens group interaction and promotes interpenetration and creation of new ideas. Leadership should be based not on power, but on the interaction of the leader and partners. In order to organize and develop social partnership, it is necessary to involve workers in management and replace enforcement with integration, which allows not only to strengthen joint actions, but also to resolve group conflicts.
Sociological Support of Personnel Policy of Social Service Organizations
Authors: Филатова Е. , Filatova E.
Published: March 2018

The purpose of the article is to discover the latest trends, principles and methods of personnel policy realization of the social service organizations. In the article on the example of the social service organizations the author argues in favor of improvement of the personnel policy of the organization on the basis of the study of the principles and methods of its realization. Monitoring revealed the dynamics changes of directions, principles and methods of personnel policy. The positive and negative aspects of personnel policy are identified. The priority directions of personnel policy are defined, the methods and principles of the personnel policy are specified. The most actual directions of personnel policy are the professional recruitment; evaluation and certification; creating a favourable atmosphere. The administrative methods are the most effective. The priority principle of the personnel policy is the principle of improvement of professional

skill.
Competence Approach as the Basis for the Formation of an Order for Additional Training Programs for Employees
Authors: Якимова Л. , Yakimova L. , Яркова С. , Yarkova S.
Published: March 2018

The article considers the mechanism of using the corporate model of competencies in Russian Railways as one of the tools for implementing the mission and the company’s strategy. The succession of this competence model to the company’s brand values is given. The analysis of the system and the training process of the structural divisions of the holding company — Road management service and The Center for Evaluation, Monitoring of Staff and Youth Policy of Krasnoyarsk Railways as one of the spheres of application of the model in question, which revealed a gap in the functions of the management cycle “control-planning” and proposed measures to reduce the cost of additional training for key employees of the company on the example of the Krasnoyarsk railway.
Multidimensional Decision Making in Operations: An Experimental Investigation of Joint Pricing and Quantity Decisions
Authors: Ramachandran Karthik , Tereyağoğlu Necati , Xia Yusen
Published: March 2018

Firms in several industries, such as medicine, apparel, and publishing, must jointly determine the price and production quantity of their products well in advance of the selling season. Normative prescriptions to solve this problem have generally ignored behavioral aspects of decision making while behavioral research has paid limited attention to interdependent, multidimensional decisions. We experimentally examine subjects’ performance when they jointly determine price and quantities. We find that subjects systematically deviate from the theoretically optimal price and quantity levels. Contrary to expectation, decomposing the price and quantity decisions does not improve subjects’ decisions. In a series of follow-up experiments, we isolate the effects of (a) interdependence between decisions and (b) demand uncertainty. We show that decisions improve by making subjects more aware of interdependence and by reducing the uncertainty. However, reducing complexity through partial automation of the interdependent dimensions does not improve the decisions made by subjects. We also find that subjects anchor on cost for price decisions and on mean demand potential for quantity decisions, thereby explaining the consistent underpricing and overordering behavior across experiments.

This paper was accepted by Vishal Gaur, operations management.
Padrões de Variabilidade em Vazões Afluentes a Usinas Hidrelétricas e Associações com Massas de Ar
Authors: De Oliveira Erick Meira , Cyrino Oliveira Fernando Luiz
Published: March 2018

Os padrões fluviais brasileiros são sensíveis a diversos fatores geográficos e atmosféricos locais e de grande escala, sofrendo variações consideráveis ao longo da extensão territorial do País. Apesar da vasta gama de informações hoje disponíveis sobre esses fatores, sabe-se que a vazão de rios brasileiros possui relações significativas com padrões climáticos bem característicos, podendo se substituir, por vezes, uma quantidade expressiva de elementos por amostras que concentrem a maior parte das informações estatísticas da base de dados. Nesse contexto, este trabalho buscou identificar, por meio da aplicação de diferentes técnicas de análise estatística multivariada, características comuns a diferentes rios brasileiros, utilizando como informação principal suas vazões. Os resultados sugerem que os comportamentos de grande parte dos rios brasileiros usados para aproveitamento hidrelétrico podem ser caracterizados por um conjunto pequeno de padrões bem definidos, que traduzem os diferentes regimes de massas de ar aos quais o território brasileiro está submetido.
Hands up if your CV ticks boxes…
Authors: Fowler John
Published: March 2018

It's worth investing time and effort when job hunting – and nowhere is this more important than when writing an application form and constructing a curriculum vitae. John Fowler reveals why
Under the umbrella of dementia
Authors: Wake Charlotte
Published: March 2018

Charlotte Wake considers the various symptoms in the context of a dental setting and suggests a little ‘blue sky thinking’ to help your patients
Sharing is caring
Authors: Verow Susie
Published: March 2018

Susie Verow is passionate about good patient communication. She even blogged recently about her experiences searching for the right mouthguard for her ruby-playing son. Here she reveals why it's ‘good to talk’
The C-Word
Authors: Earl Joe
Published: March 2018

With No Smoking Day taking place this month, Dental Sky's Joe Earl considers oral cancer and the need to screen
Step Ahead in Aesthetics: what is on the agenda for 2018?
Authors: Senior Amy
Published: March 2018

Spring is now approaching and for the Private Independent Aesthetic Practices Association, this means the annual Step Ahead in Aesthetics conference is firmly on the horizon. This one-day event will take place in Bury, with an agenda focused on quality, not quantity. Amy Senior shares details of the three major sessions of the day and tells practitioners how to secure a place
Sole proprietors' perceptions of benefits of and barriers to using digital marketing
Authors: Hurst James
Published: March 2018

A survey was completed by a sample of 33 sole proprietors in Merseyside, 18 of whom worked in the aesthetics sector. It was found that respondents lacked the necessary knowledge and time to undertake digital marketing, and the cost implications affected their success. Perceived benefits included increased reach, exposure and communication, which allowed sole proprietors to remain competitive
The complain game: how to prevent problems and reach resolutions
Authors: Hool Claire
Published: March 2018

No matter the depth of your experience, the reputation of your establishment or the competency of your staff, sometimes things do not go according to plan and you end up with a complaint on your hands. Claire Hool discusses some common issues she has experienced while working in the aesthetics sector and shares her top tips on resolving issues that can arise between you and your customers
Why is the microsclerotherapy consultation so important?
Authors: Judge Claire
Published: March 2018

Many clinicians recognise the value of the consultation process in the overall service they deliver to their patients. Conducting a comprehensive consultation can help to set realistic expectations, and achieve better treatment outcomes and greater patient satisfaction. Claire Judge explains why the consultation is such a crucial part of the process for microsclerotherapy patients
Radiofrequency treatment for vulvovaginal laxity and sexual dysfunction
Authors: Adib Tania
Published: March 2018

Vulvovaginal laxity due to childbirth, ageing and the menopause is a condition which is rarely discussed by women but which can lead to discomfort, bladder symptoms and sexual dysfunction. Adequate pelvic floor function is essential for good sexual health. Sexual health is intricately related to good general health, as well as self-esteem and self-confidence. Treatments for vulvovaginal laxity range from pelvic floor exercises to surgical intervention with its associated risks. Transcutaneous temperature-controlled radiofrequency treatment bridges that gap and offers women more choices to restore their vaginal function. This article reviews the available evidence and application and efficacy of radiofrequency treatments for vulvovaginal laxity.
How does Instagram impact on people's perceptions of their appearance?
Authors: Woodley Abigail
Published: March 2018

Although research has demonstrated links between appearance perceptions and exposure to ‘traditional’ media and social networking sites, there have been fewer explorations into the potential impact of Instagram. With social media usage and the popularity of Instagram at an all-time high, Abigail Woodley investigates its influence on the self-perceptions of photo-sharers
COMPORTAMENTO DE HÍBRIDOS DE MILHO COM DIFERENTES FONTES NITROGENADAS PARA O VALE DE SÃO PATRÍCIO
Authors: Silva Welcio Rodrigues , Buso Wilian Henrique Diniz , Firmiano Raquel Silva , Silva João Marcos Guedes
Published: March 2018

O crescimento dos sistemas de produção com utilização de tecnologias nos cerrados tem demandado largamente o uso de híbridos de milho de melhor adaptação, tornando-se necessário avaliar o desempenho para fazer as recomendações aos produtores das diversas regiões. Com isso objetivou-se com essa pesquisa avaliar o desempenho de híbridos de milho sob duas fontes de nitrogênio (N) em condições de cerrado na região de Ceres, Vale de São Patrício, Goiás. O Delineamento experimental utilizado foi de blocos completos ao acaso em esquema fatorial 10x2 (dez híbridos de milho e duas fontes nitrogenadas) com quatro repetições. O plantio foi realizado em 29 de novembro de 2013, o sistema de cultivo adotado foi o plantio convencional. A colheita foi realizada em 15 de maio de 2014. Comparando os híbridos nas diferentes fontes, resultados mostram que o híbrido BG7049H foi superior utilizando ureia. Já o híbrido BG7032H foi superior com Novatec, ambos para variável diâmetro do colmo. Para as variáveis altura de planta e de espiga, comprimento de espiga, número de grão por fileira e número de fileiras de grãos, não foram identificadas diferenças significativas para as fontes de N estudadas. Para massa de 1000 grãos os híbridos que apresentou valores superiores foram P3646H, P4285H, LG6304 e BG7032H. Em relação à produtividade os híbridos P3646H, 30A91PW, 30A16PW e 30A37PW foram os mais produtivos para as condições desse experimento.
CONSÓRCIO DE MILHO COM FEIJÃO DE PORCO VISANDO A IMPLANTAÇÃO DO SISTEMA PLANTIO DIRETO
Authors: Souza Luis Felipe Brito de , Pinto Antônio Alves , Camara Felipe Thomaz da , Mota Antonio Marcos Duarte , Da Silva Cícero Secifram
Published: March 2018

O milho é um dos cereais mais importantes cultivados no mundo, com o sistema plantio direto sendo a forma de plantio que mais cresce, usando-se semeadoras especiais com a finalidade de manter ou aumentar o conteúdo de matéria orgânica, além disso, são capazes de melhorar as qualidade físicas, químicas e biológicas do solo. Objetivou-se nesse trabalho avaliar o desenvolvimento e a produtividade do milho consorciado com feijão de porco para a implantação do sistema plantio direto na região do Cariri cearense, em Assaré-CE. O experimento foi desenvolvido em delineamento em blocos casualizados em esquema fatorial 3 x 2, com quatro repetições, totalizando 24 observações. O primeiro fator foram três níveis de adubação de fundação (0, 100 e 150%, sendo estas porcentagens em relação à dose recomendada), e o segundo fator foi referente à calagem (com e sem calcário). Os resultados permitiram concluir que a adição de adubo mineral a partir da dose ideal elevou os índices de desenvolvimento e produtividade da cultura do milho, com a calagem não apresentando resposta significativa em função do alto valor de saturação por bases inicial do solo.
HISTÓRIAS DE LITERATURA: conflitos e caminhos
Authors: Olinto Heidrun Krieger
Published: March 2018

O objetivo desse artigo é indagar mais uma vez: quais poderiam ser hoje as motivações para escrever histórias (de literatura) e que tipo de argumentos poderiam ser convenientes para justificar determinadas escolhas que privilegiam e definem modos específicos de sua compreensão, de sua função e dos modos de sua representação.
IDENTIDADES EM CURSO: José de Alencar e a hipótese Brasil
Authors: Helena Lúcia
Published: March 2018

Apresenta-se uma leitura da atuação literária de José de Alencar na esteira da formação das identidades brasileiras.
DO ESCRITOR EM EXÍLIO CÍVICO à saudável experiência de escrever em liberdade
Authors: Silva Teresa Cristina Cerdeira da
Published: March 2018

Trata-se de uma leitura crítica da literatura portuguesa.
AINDA, NARRATIVAS DE JORGE AMADO
Authors: Rios Márcia
Published: March 2018

Este artigo discute aspectos da recepção contemporânea da narrativa de Jorge Amado.
O PRESÉPIO SERTANEJO de Crispina dos Santos
Authors: Dórea Juraci
Published: March 2018

O artigo trata da obra da ceramista feirense Crispina dos Santos, em particular, dos presépios.
A BRASILIANA de Policarpo Quaresma: modelo, moldura, mediação
Authors: Pereira Elvya Ribeiro
Published: March 2018

O artigo discute o modelo de identidade brasileira representado no personagem Major Quaresma, na obra de Lima Barreto, "Triste fim de Policarpo Quaresma'.
LUDUS E LITTERA: artimanhas da memória
Authors: Abelha Alves Maria Tereza
Published: March 2018

O artigo realiza uma leitura de Canto de Alvorada de Aleilton Fonseca, analisando o protocolo narrativo da obra.
LER E RELER CECÍLIA MEIRELES: A escuridão e as águas de cristal
Authors: Helena Lúcia
Published: March 2018

O artigo trata da obra de Cecilia Meireles, primeira dama do modernismo, que não obedece à temporalidade de uma concepção radical e vanguardista. Em plena vigência do clamor pelo novo, seus versos recuperam formas e temas da antiguidade, da lírica medieval, do classicismo, do barroco, do romantismo e do simbolismo.
ARCANOS & EXÍLIO na poesia de Mª L. Alvim e Roberval Pereyr
Authors: Simpson Pablo
Published: March 2018

Este artigo discute a presença de formas do exílio na tríade de poemas Progenitura”, publicada em Romanceiro de Dona Beija (1965- 1975), de Maria Lúcia Alvim e, em seguida, através de três poemas de Roberval Pereyr.
ADÉLIA PRADO: A poesia em diálogo
Authors: Patrício Rosana Ribeiro
Published: March 2018

O artigo trata da  intertextualidade na poesia de Adélia Prado, enfatizando o trabalho da citação como diálogo.
REFLEXOS DE RIMBAUD em autores do século XX
Authors: Vuillemin Alain
Published: March 2018

O simbolismo foi censurado por ter sido, na França, nas imediações de 1900, uma “escola de poetas estrangeiros”. Foi, ao contrário, o que deu riqueza, vitalidade e diversidade a este movimento no século XX. Sabe-se o papel que poetas como Jean Moréas, Maurice Maeterlinck, Stuart Merrill, Francis-Viété Griffin representaram na França com relação à gênese e difusão das idéias e concepções estéticas simbolistas, mas se conhece menos o que se passou com outros autores de expressão francesa oriundos de outros horizontes, Alphonsus de Guimarães no Brasil, Albert Lozeau no Quebeque, Alexandru Macédonski na Romênia, Lubomir Guentchev na Bulgária. São esses reflexos das “Iluminações” de Arthur Rimbaud que se tentará abordar nas obras desses últimos.
CASAS DA MEMÓRIA: Figurações da cidade em Murilo Mendes
Authors: Fiorese Furtado Fernando Fábio
Published: March 2018

Em A idade do serrote (1968), volume inaugural da prosa memorialística de Murilo Mendes, o poeta visionário opera a “tradução lendária” da infância a partir da simbólica do espaço edênico e seus desdobramentos. Mas é a imagem/metáfora “casa” que se expande até dominar toda a cidade, locus ora erotizado pela presença materno-feminina (casas fêmeas), ora ordenado pelas medidas do Pai (casas masculinas).
América Latina
Authors: De Oliveira Reis Santana Evila
Published: March 2018

A resenha trata do livro de Eduardo F. Coutinho, Sentido e função da literatura na América Latina. Rio de Janeiro: Faculdade de Letras/UFRJ, 2000.
Reflexões sobre o surgimento, a morte e o retorno das noções de autor e sujeito
Authors: Beccaccia Versiani Daniela
Published: March 2018

Este ensaio discute as reflexões de dois pensadores contemporâneos sobre os conceitos de autor e sujeito. Inicialmente apresenta a constelação de três fatores que, segundo Hans Ulrich Gumbrecht, teriam possibilitado, na era moderna, o surgimento das noções de autor e sujeito: a institucionalização da técnica de impressão de textos e sua conseqüente circulação independente da presença física de seu autor; o processo de colonização da América e o surgimento do sistema burocrático. Em seguida, resume a discussão levantada por Seán Burke sobre as conseqüências éticas e políticas das afirmativas pós-estruturalistas do fim das categorias de autor e de sujeito, que marcaram boa parte das discussões filosóficas e teórico-literárias da segunda metade do século XX. Por fim, sugere a retomada das noções de sujeito e autor vinculadas agora à necessidade de construir a visibilidade social, cultural e política de novas e alternativas subjetividades bem como uma episteme aberta e plural.
As trapaças de um sofista ou da aprendizagem da insubmissão em Lavoura arcaica, de Raduan Nassar
Authors: Wrege Rassier Luciana
Published: March 2018

O escritor e jornalista paulista Raduan Nassar publica Lavoura arcaica em 1975, durante a ditadura militar. Esse romance, frequentemente descrito como uma versão da parábola bíblica do filho pródigo, põe em cena o universo de uma família organizada em torno da ordem paterna, de valores austeros baseados no trabalho e na disciplina. Longe dos estereótipos de uma suposta “literatura engajada”, Lavoura arcaica trata do questionamento tanto das relações de força quanto de uma ordem imposta, que pode ser desmascarada graças ao estudo das técnicas retóricas utilizadas pelas personagens. Com efeito, se o leitor implicar-se em identificar as estratégias de manipulação através da arte oratória, ele conseguirá evitar as eventuais armadilhas que elas podem criar, seja nesse romance ou em outros textos e discursos. Tal incitação à reflexão própria e à insubmissão a uma ordem arbitrária permanece atual, trinta anos após a primeira edição de Lavoura arcaica.
As “crônicas históricas” de Franklin Távora e sua “literatura do Norte”
Authors: Bastos Alcmeno
Published: March 2018

Franklin Távora (1842-1888) deixou, como realização de sua proposta de uma “Literatura do Norte”, três romances: O Cabeleira (1876), O matuto (1878) e Lourenço (1881); e uma novela: Um LEGUA E MEIA copia.indd 184 17/11/2014 22:48:49 Légua & meia: Re v i s ta d e Li t erat ura e Di v ersida de Cu lt ura l, a. 13, n o 6, 2014 185 casamento no arrabalde (1869). Nessas quatro obras se misturam duas coordenadas preponderantes na ficção de Távora: a indiscutível tendência regionalista, que justifica o designativo geográfico “do Norte”, dado que, no seu entender, haveria uma literatura, a “do Norte”, autenticamente brasileira, por oposição à literatura “do Sul”, e a reconstituição ficcional do passado histórico da região, como o indica o subtítulo “Crônicas pernambucanas”.
Apresentação - Dossiê 50 anos de " Deus e o Diabo na terra do Sol" e homenagem a Jerusa Pires
Authors: Novaes Claudio
Published: March 2018

Apresentação
(DE)CANTANDO CORISCO em Deus e o Diabo na Terra do Sol
Authors: Freire Júnior Orlando
Published: March 2018

Glauber Rocha, em texto dirigido a Sérgio Ricardo, declarou ter conhecido as histórias do cangaço pela voz dos poetas de cordel. Partindo dessa informação, este texto analisará a influência da literatura de cordel na construção do personagem Corisco em Deus e o Diabo na Terra do Sol.
O SERTÃO DILACERADO: outras histórias de Deus e o Diabo na Terra do Sol
Authors: Gomes Pereira Pedro Paulo
Published: March 2018

A busca deste texto será a de compreender como uma das mais importantes narrativas do cinema nacional – Deus e o Diabo na Terra do Sol, de Glauber Rocha (1963) – construiu o sertão, quais as imagens e as figuras utilizadas, e como esse sertão delineia e projeta o Brasil.
CAPELAS SERTANEJAS: via sacra lírica e dramática nas estradas do calvário
Authors: Novaes Claudio
Published: March 2018

Este ensaio traz algumas fotografias do nosso acervo pessoal que guarda registros da memória sertaneja. As fotos trazem algumas imagens de Capelas erguidas nas margens das rodovias e estradas, compondo um cenário lírico e dramático, como que expressa uma liturgia misteriosa e resistente da morte e vida na memória do sertão. São raras as rodovias que cortam o Nordeste brasileiro que não exibem capelas em suas margens, quase sempre erguidas em homenagens póstumas aos mortos por atropelos e outros incidentes perpetuados na memória pelas  casinhas cravadas de cruzes.
MEMÓRIA ANCESTRAL e o Brasil contemporâneo – Tradição junguiana e o inconsciente brasileiro
Authors: Vrbata Ales
Published: March 2018

Este artigo tem como seu ponto de partida algumas teses fundamentais da psicologia arquetípica, teses desonvolvidas por C. G. Jung e na virada dos anos 1960 e 1970 extensivamete desenvolvidas pelo James Hillman: 1) a imagem como manifestação primária e viva da psique e não como conceito teórico, 2) a necessidade do mito cultural vivo de cada comunidade humana, 3) aconsciência como titular das polaridades (oposições). Estas três teses podem servir como ponto de partida para a interpretação do encontro histórico da cultura europeia/portuguesa do século XVI e da cultura das tribos indígenas brasileiras e por isso também para a interpretação da cultura contemporâneabrasileira. São justamente essas teses que formam a base do pensamento do analista Roberto Gambini. Este estudo pretende apresentar o pensamento de Gambini sobre a identidade e a alma brasileira e referir-se as outras perspectivas junguianas abertas por conceito recente do “complexocultural” e como é aplicado nas condições brasileiras.
A MEMÓRIA VIVA gerada por Jerusa
Authors: Bezerra Filho Feliciano José
Published: March 2018

O presente artigo é um depoimento que aponta para o percurso intelectual e acadêmico da professora e pesquisadora Jerusa Pires Ferreira, destacando sua contribuição docente e teórica em torno de questões da semiótica da cultura, e dos caminhos e avanços da pesquisa em oralidade no Brasil e no mundo. Para tanto, o artigo apresenta e explora a obra Armadilhas da Memória e outros ensaios, livro publicado pela autora em 2004.
Narratologia transmedia e transmedia storytelling
Authors: Ryan Marie-Laure
Published: March 2018

O termo transmedia storytelling tornou-se viral na área dos media studies. Mas, em que medida é que este termo define um fenómeno verdadeiramente novo e diferente dos conceitos já conhecidos de adaptação e transficcionalidade? O que significa realmente contar uma história através de diferentes media e em que condições isto é uma mais-valia? Neste artigo, serão avaliados vários tipos de projetos que se podem considerar de transmedia storytelling, embora não se enquadrem necessariamente no paradigma transmedia da ‘Costa Oeste’ dos Estados Unidos (i.e. Hollywood), bem como analisados três tipos de discurso associados a este fenómeno – o discurso da indústria, o discurso dos fãs e o discurso académico –, esperando poder diferenciar este último dos outros dois e, assim, definir alguns dos seus objetivos.
Epidemiology and Management of Seasonal Influenza Outbreaks in Long-Term Care Facilities in the Health Service Executive East Area of Ireland During the 2013-2014 Influenza Season
Authors: OâConnor L. , Murphy H. , Montague E. , Boland M.
Published: March 2018

We describe seasonal influenza-like illness (ILI) outbreaks in long-term care facilities in the Health Service Executive (HSE) East area of Ireland in the 2013/2014 influenza season, risk factors associated with outbreak duration and attack rates, and management challenges. Separate questionnaires were distributed to 28 facilities who reported an outbreak and to public health specialists leading outbreak management, with a 79% response rate. Mean outbreak duration (21 vs 17 days; p=0.046) was longer in facilities with staff vaccination rates of <40%. Facilities with a high attack rate (â¥50%) were less likely to have an outbreak plan (p=0.03). Smaller facilities (under 50 residents) had a higher attack rate (50% vs 23%, p=0.003) even when controlled for staff vaccination rate (p=0.01). Prior to the outbreak, resident vaccination rates were high (82%, above the World Health Organization target of 75%) but staff vaccination rates were low (39%). Reported challenges to ILI outbreak management in long term care facilities included visitor restrictions, staff education issues, outbreak notification delays and lack of outbreak lead in facilities. Targeted public health-assisted planning, training and response, comprising of staff vaccination, education, written policies, with early notification and prompt response would facilitate a more co-ordinated approach to the management of outbreaks, and reduction in infection rates and consequent morbidity.
COMPARISON OF ACTUAL GROUND SETTLEMENTS IN TUNNELLING EXCAVATION TO MODEL PREDICTIONS
Authors: Saplachidi Alexandra , Vougioukas Emmanouil
Published: March 2018

It has been discovered that the underground structures are vulnerable to seismic phenomena mainly due to permanent ground deformations caused by earthquakes rather than the dynamic seismic movement itself. Several models (empirical formulae) have been developed to estimate such deformations. In this paper, measured settlements from the tunnelling excavation for the extension of Line 3 of the Athens Metro (from Egaleo station to Chaidari) are used for the verification and calibration of such formulae. Firstly, some general information is presented concerning the progress of Line 3 so far. Typical buildings, infrastructure and utility grids that can affect the design and construction of the tunnel are examined. Typical geological, hydrogeological and geotechnical conditions along the axis of the excavation, as specified by laboratory tests, are presented as well. According to these conditions, ground settlements are predicted along the tunnel. Secondly, a comparison is made of the actual values of the ground settlements, which come from geotechnical and structured observations, and the estimates provided by the empirical formulae. Some improvements are proposed for this formulae through the RS2 software program (Phase 2 v.9.0) by Rocsience. The improved model is then used to estimate strains that could be induced by future earthquakes.
Evaluation on performance of some Sorghum bicolor cultivars as forage resources in the dry land with dry climate
Authors: Sajimin Sajimin , Purwantari Nurhayati D. , . Sarjiman , . Sihono
Published: March 2018

The aim of this study was to evaluate the performance of several Sorghum bicolor cultivars as forage on a dry land with pH of 5.4, N of 0.08%;  C/N of 9%, P of 0.06% and K of 0.01%. Nine cultivars of S. bicolor (Super 1, Super 2, Numbu, Kawali, G2, G5, PAC 537, PAC 593 and PAC 501) were evaluated. Plot size was 16 m2 with space planting of 15 x 75 cm. The experimental design used was randomized block design with three replications.  Parameters observed were plant height, time of flowering, forage production and quality. The result showed that the primary plant growth was not different in all cultivars. In the 65 days old primary plant,  the Super 2, PAC 537 and Kawali had no flower yet. Biomass production varied in primary plant between cultivars of 11.35 - 26.17 kg/16 m2. The highest biomass production was obtained in PAC 537 of 26.17 kg/16 m2 (16.34 t/ha) which were significantly higher than G2 of 11.35 kg/16 m2 (7.09 ton/ha) and was not significantly different with other cultivars. In the 45 days ratoon I, Super 2, G5 and Super 1 showed faster growth. Biomass production increased in the ratoon I around 19.88 kg/16 m2 (12.42 ton/ha). PAC 537 produced the highest biomass of 30.14 kg/16 m2 (18.84 ton/ha) and was not significantly different with other cultivars, except with the G2. Biomass production of ratoon II decreased around 1.83 kg/16 m2 (1.14 t/ha)–4.77 kg/16 m2 (2.98 t/ha) and increased in the ratoon III of 15.72 kg/16 m2 (9.82 t/ha)–26.05 kg/16 m2 (16.28 t/ha). The quality of forage ratoon I was better compared to the primary plant with the lowest one was in ratoon II. It could be concluded that Super 1, Super 2 and PAC 537 cultivars might be recommended as potential forage.