bluuebunny/crossref_metadata_2025 huggingface dataset:
NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes
Authors: Simenc Janez , Juric Damijana Mojca , Lipnik-Stangelj Metoda
Published: January 2019

Background

Astrocytes maintain central nerve system homeostasis and are relatively resistant to cell death. Dysfunction of cell death mechanisms may underlie glioblastoma genesis and resistance to cancer therapy; therefore more detailed understanding of astrocytic death modalities is needed in order to design effective therapy. The purpose of this study was to determine the effect of VAS2870, a pan-NADPH oxidase inhibitor, on staurosporine-induced cell death in astrocytes.

Materials and methods

Cultured rat astrocytes were treated with staurosporine as activator of cell death. Cell viability, production of reactive oxygen species (ROS), and mitochondrial potential were examined using flow cytometric analysis, while chemiluminescence analysis was performed to assess caspase 3/7 activity and cellular ATP.

Results

We show here for the first time, that VAS2870 is able to prevent staurosporine-induced cell death. Staurosporine exerts its toxic effect through increased generation of ROS, while VAS2870 reduces the level of ROS. Further, VAS2870 partially restores mitochondrial inner membrane potential and level of ATP in staurosporine treated cells.

Conclusions

Staurosporine induces cell death in cultured rat astrocytes through oxidative stress. Generation of ROS, mitochondrial membrane potential and energy level are sensitive to VAS2870, which suggests NADPH oxidases as an important effector of cell death. Consequently, NADPH oxidases activation pathway could be an important target to modulate astrocytic death.
Primary Total Knee Arthroplasty (TKA) with revision Total Stabilizer Prosthesis in a 66-year-old patient with secondary knee osteoarthritis and valgus deformity. Case Report
Authors: Gherman Mihai , Sere Anca-Mădălina , Angheluță Mihai-Daniel , Coste Remus
Published: January 2019

Knee osteoarthritis (gonarthrosis) is the most prevalent knee pathology encountered nowadays in the third age population, leading to severe disability and reduced life quality. Secondary gonarthrosis may be caused by a traumatic event, which subjects the knee joint to a transitory highly increased mechanical stress, initiating a rapidly progressive degrading process of the articular cartilage and subjacent bone tissue. TKA is intended to replace all the intra-articular components with artificial parts, in order to relieve pain, compensate for ligament instability, correct deformities, and restore proper joint functionality. Semi-constrained, non-hinged implants are usually used for revision TKA, in knees that already had a primary TKA but sustained complications. Nevertheless, here we reported the case of a 66-year-old female patient diagnosed with posttraumatic gonarthrosis who underwent TKA with a revision total stabilizer implant as primary treatment due to severe joint instability and high grade valgus deviation. The outcome of the surgical procedure was positive, with significant pain relief and increased knee stability. The valgus angle was reduced from 37° to 4° and the KSS score increased from 3 to 87 points. Therefore, revision semi-constrained prosthesis may be used as a primary implant with promising result in severe cases.
Analysis of the Determinant Factors of the Historical Development of Air Transport: An Empirical Application to Turkey
Authors: Kiraci Kasim
Published: January 2019

The aim of this study was to empirically examine the development of air transport in Turkey in the period between 1980 and 2015. The study intended, within its scope, to determine the developments experienced in air transport in Turkey and the probable causes of the structural changes. Moreover, it was aimed at highlighting the years in which the structural changes in air transport were realized. In line with this objective, the one-break Zivot Anderews (1992) unit root test, the two-break Clemente-Montañés-Reyes (1998) unit root test, and the one-break and two-break LM were applied to the domestic and international air transport data of the 1980-2015 period. The results of the study show that there were substantial economic and political developments both at home and abroad in the years that the significant structural breaks that affect air transport took place.
Taludes de barragem: análises determinísticas e probabilísticas – estudo de caso
Authors: Andrade Vanessa , Filho Rodrigo , K. Puppi Rogério , Johann Amanda , Rose Juliana , Santos Izzo Ronaldo
Published: January 2019

Atualmente, as análises determinísticas são utilizadas com grande frequência para a obtenção de um fator de segurança de taludes, apresentando todavia limitações na consideração das incertezas associadas à variabilidade dos parâmetros de resistência dos materiais. As análises probabilísticas permitem resolver este problema, porém, são pouco difundidas no meio técnico. Assim, apresenta-se neste trabalho comparações entre análises determinísticas, pelos métodos de Bishop simplificado e Spencer, e probabilísticas, pelo Método de Monte Carlo, através do estudo de caso de uma barragem utilizando o software Slope/W da GeoStudio. Também são feitas comparações com os critérios estabelecidos pela Eletrobrás e pelo USACE. Verificou-se que a barragem possui seus fatores de segurança dentro dos limites estabelecidos por ambos os critérios. Verificou-se ainda a facilidade de utilização do método probabilístico, desde que existam dados suficientes disponíveis para as análises.
VERIFIKACIJA REZULTATA EMS PRORAČUNA KROZ IZMENU MODELA
Authors: Zukorlić Nemanja , Đukić Savo
Published: January 2019

U radu je izvršena verifikacija rezultata nekoliko funkcija softvera za upravljanje prenosnim mreža­ma kroz izmenu modela. Ukratko su opisane najvažnije funkcije softvera za upravljanje prenosnim mrežama. Na­kon toga, kroz nekoliko primera izmena modela prenosne mreže, izvršena je analiza rezultata funkcija i dati su osnovni zaključci rada.
SOFTVERSKO REŠENJE ZA PRIKAZ GRAF MODELA
Authors: Marić Momir
Published: January 2019

Dokument uopšteno opisuje problem, strukturu, rešenje i dobijene rezultate softverskog rešenja. Softversko rešenje je u stanju da stvori, rasporedi i prezentuje jedan matematički graf uprošćenog realnog sistema.
VREDNOVANJE PREDLOGA REŠENJA ZA POBOLJŠANJE USLOVA ODVIJANJA SAOBRAĆAJA NA RASKRSNICAMA NA Bulevaru Evrope
Authors: Jovanović Katarina
Published: January 2019

Ovaj rad prikazuje način analiziranja saobraćaja na raskrsnicama i predlog mera za pobolj­šanje uslova odvijanja saobraćaja sa funkcionalnog i ekonomskog aspekta.
МЕРЕ ЗЕ ПОВЕЋАЊЕ КВАЛИТЕТА УСЛУГЕ ТРАНСПОРТА ПРЕДУЗЕЋА „ЕУРО ЛИДЕР“ ДОО- ЖБЕВАЦ
Authors: Младеновић Стефан , Гладовић Павле
Published: January 2019

Основни циљ израде овог рада јесте упознавање начина пословања транспорта, и да се кроз анализу возног парка уоче недостаци у пословању овог предузећа и предложе мере за превазилажење тих проблема. Потребно је анализи­рати организациону структуру, структуру возног парка, обрадити финансијске резултате, како би се уочили недостаци и самим тим предложиле мере које ће довести до успешног пословања предузећа.
Contact Stress Analysis of Spur Gear Under the Different Rotational Speed by Theoretical and Finite Element Method
Authors: Mohammed Jwan Kh. , Khdir Younis Kh. , Kasab Safeen Y.
Published: January 2019

In this study that spur gears are chosen, contact stress of spur gear is presented under the effect of rotational speed. Three-dimensional simulation of dynamic analysis of gears designed and modeled using ANSYS software. The dynamic analysis included in the determination of dynamic stresses analysis. Contact stress is theoretically calculated and analyzed and numerically estimated using both Hertzian mathematical model and finite element method respectively. Different values of rotational speed used to study its effect on contact stress. Both methods compared by evaluating the percentage error of contact stress, and the modeling of the spur gear and stress analysis of spur gear carried out using SOLID WORK and ANSYS V14, respectively. The most significant note in this study concludes that increasing speed causes vibration and pitting failure due to repetitions.
Real-time Liquid Level and color Detection system using Image Processing
Authors: Samann Fars E.
Published: January 2019

Detecting the level of the liquid is very essential for any chemical study in research labs. The objective of this paper is to design real-time liquid level detection system using image processing. Besides, this system is able to indicate the color of the liquid during chemical reaction. The proposed system was developed using vision assistant tools in LabVIEW and webcam. Regarding to webcam resolution, the average accuracy of the system is approximately 99%.
Modeling and Implementation of a PV-powered DC Water Pump System for Irrigation in Duhok City
Authors: Sado Kerry A. , Hassan Lokman H.
Published: January 2019

The agriculture sector nowadays relies mostly on conventional energy sources and traditional irrigation ways. Considering some factors such as high costs of fossil fuels and providing new power lines, especially to remote locations and where grid electricity is either inaccessible or expensive, a solar PV powered irrigation system can be a practical choice for irrigating crop fields. In this paper, a PV-powered dc water pump system design for irrigation is presented. A comprehensive comparison between Direct Current (DC) and an Alternative Current (AC) motors powered by PV is carried out in terms of power, current, water discharge and cost. Dominant factors of the system such as the effect of solar radiation on motor power, current, and water discharge are considered in this study. The optimum tilt angle for Duhok city is considered to perform this study. The specifications of PV, DC and AC motors are tested in Matlab Simulink to show the performance of the system components. The results show that DC motor is preferred over AC in term of system complexity, cost and power consumption. In contrast, water discharge of AC pump is slightly higher than the DC pump for the same time. However, overall results demonstrate the superiority of DC motor over AC.
Slant shear strength of hybrid concrete made with old and new parts using reactive and inert waste powders
Authors: Haido James H. , Dinkha Youkhanna Z. , Abu-Bakar Badorul H.
Published: January 2019

Manufactured reactive powders, as a silica fume, are usually used in production of high strength concrete with for retrofitting purposes of concrete structures. The efficiency of inert waste glass powder in hybrid concrete fabrication has not been widely investigated, thus further studies are essentially considered in this area. In the present study, hybrid concrete prisms with size of 10x10x30 cm have been made with old ordinary concrete (OC) and new high strength concrete (HSC). High strength of new concrete part of these prisms is achieved via using of waste glass powder, silica fume and mixture of them. The roughness of interfacial surface between old and new parts of hybrid concrete is improved in various manners with utilizing sand blast, holes and grooves. Performance of these elements has been measured in terms of slant shear strength and mode of failure. The results have been shown that there is a relatively similar strength with using retrofitted concrete made with the used powder which includes silica fume, glass powders, and their mixture, the mixture of both powders, namely, silica fume and waste glass powders is regarded a best choice in the present stud. It is demonstrated also that the grooved interface between old and new concretes induces proper strength equivalent to 89% of control concrete prisms strength.
The impact of residential septic tanks on soil water infiltration and groundwater contamination in Duhok city
Authors: Kochary Shawkat A. , Alnaqshabandi Lamyaa M. Hasan , Abdo Hassan R.
Published: January 2019

This study was conducted to assess the impact of septic water on soil water infiltration in Duhok city potentiallycontaminating regional groundwater through designing a large-scaled laboratory physical model of vertical flowdirection packed homogenously with silt-Clay soil. The designed model was supplied with newly collected septicwater. With steady-state flow condition, the model was run, water samples were collected and analyzed weekly.Various parameters and constituents that may influence soil structure and water infiltration were examined including : Electrical conductivity, sodium, calcium, magnesium, carbonate, bicarbonate, residual sodium carbonate (RSC), pHc and adjusted sodium absorption ratio (adj. SAR). For assessing groundwater quality, bacteriological analysis were conducted. Analytical results were used to estimate the examined parameters and predict their future trends. Results revealed that electrical conductivity (EC) was accumulating until it reaches the carrying capacity. Sever hazard of (RSC) was detected within 25 meter depth. Average pHc was 6.74 indicating the tendency of lime (CaCO3) to precipitate from applied septic water. adj. SAR for port A and port B were 11.1 and 8.65 respectively which, caused severe soil deterioration, but on the other hand helped in decreasing the rate of contaminants transport for treatment within the soil before reaching the groundwater. Results of bacteriological analysis indicated that groundwater shallower than 31 meter was contaminated by fecal and total coliform bacteria. This study helped local authorities in establishing precaution strategies of groundwater management to protect public health.
Sonolência excessiva diurna em alunos do último ano do curso de fisioterapia de uma faculdade privada
Authors: Moraes Jéssica Barroso de , Siebra Taiane dos Santos , Paz Karla Rayane Azevedo , Filho Carlos Antônio da luz , Luz Karla Rakel Gonçalves , Sousa Adriano Correia de , Lima Ana Beatriz Araújo , Lima Manuela Teixeira , Lima Gabriela Teixeira , Souza Rodrigo de Lima
Published: January 2019

Objetivo: Verificar através de escalas quantos alunos do último ano do curso de fisioterapia de uma faculdade privada apresentam a Sonolência Excessiva Diurna como também avaliar uma possível associação com a ansiedade. Além disso, comparar os dados obtidos entre alunos do último ano e períodos anteriores, e identificar suas principais queixas relacionadas ao sono. Metodologia: Trata-se de uma pesquisa de campo do tipo transversal e controlada, com abordagem quantitativa onde se utilizou as escalas de ansiedade de Beck e Epworth. Participaram do estudo 93 alunos, sendo 47 alunos do último ano e 46 de anos anteriores. Resultados: A Sonolência Excessiva Diurna acometeu 31 (66%) alunos concluintes, resultado este mais prevalente quando comparado aos alunos de períodos anteriores que obtiveram um N de 15 (32,6%) estudantes. Na escala de ansiedade de Beck, ambos os grupos não apresentaram resultados relevantes. No entanto, como queixa principal relacionada ao sono houve uma prevalência da insônia em alunos do último ano, enquanto que os alunos de períodos anteriores relataram demorar mais a dormir, devido a não possuírem horários regrados para concluir suas atividades. Conclusão: Portanto, a Sonolência Excessiva Diurna foi mais prevalente nos alunos do último ano, contudo, os alunos de períodos anteriores não estão adotando hábitos saudáveis de sono, o que pode gerar repercussões negativas ao chegarem ao final do curso.
Düzce’de Göçmenlerin Sorunlarına Çözüm Modelinin Kamu Politikası Açısından Analizi
Authors: DAĞLI Zülkif
Published: January 2019

Göç politikası, pek çok
alt politika alanını da etkileyen meta bir konudur. Türkiye de son yıllarda bu
alanda ciddi değişimler yaşamaktadır. Suriye’deki krizle daha da derinleşen
ulusal göç sorunu, yerelde de farklı sorun alanlarına yol açmaktadır. Özellikle
göçmenlerin başta uyum olmak üzere farklı başlıklar altında sorunlar
yaşadıkları ve bu sorunların yerleşiklere de yansıdığı izlenmektedir. Bu
kapsamda Düzce örneğinde yaşanan sorunlar ve çözüm önerileri araştırılmıştır.
Gerçekleştirilen saha araştırmasıyla yürütülen faaliyetlerin etkileri
değerlendirilmiştir.
Doping in Garnet-Type Electrolytes: Kinetic and Thermodynamic Effects from Molecular Dynamics Simulations
Authors: Mottet Matthieu , Marcolongo Aris , Tavernelli Ivano , Laino Teodoro
Published: January 2019

Molecular modeling using polarizable force fields of W-doped lithium containing garnets to understand the various aspect of the impact of doping on the lithium dynamics and conductivity.
Organizational basis of cardiorehabilitation
Authors: Misyura O. F , Shestakov V. N , Zobenko I. A , Karpukhin A. V , Aleksandrov P. V , Goryunova A. A
Published: January 2019

Evaluation of long-term experience cardiac rehabilitation in a rehabilitation center "Chyornaya rechka" allowed to formulate general technology rehabilitation of cardiac patients in different categories. The key points of technology at the 2nd stage of rehabilitation are the risk stratification, evaluation classes severity of patients in a rehabilitation center, multidisciplinary rehabilitation. In practice cardiorehabilitation used notion of rehabilitation potential and prognosis of rehabilitation. Suggested modular design personalized rehabilitation programs. The modular structure allows individual programs to achieve optimum results of rehabilitation, facilitating current and final control effectiveness.
Diagnosis and the debatable issues of the treatment of heart failure with preserved ejection fraction
Authors: Akhilgova Z. M , Kurkina M. V , Dzhioeva Z. R , Puhaeva A. A , Avtandilov A. G
Published: January 2019

Heart failure with preserved fraction (HFpEF) amount for a half of the general heart failure and increasing progressively. In this review we discuss the issues of pathogenesis of HFpEF, illuminated in the recent literature in the last years. Considering the heterogeneity of the pathophysiology of this syndrome and the results of large-scale studies conducted nowadays, it considers the debatable treatment issues of the applying different drugs in the prevention of HFpEF.
Clinical case of chronic rheumatic heart disease that was not diagnosed during patient’s lifetime
Authors: Tsibulskaya N. Yu , Harkov E. I
Published: January 2019

The article presents a clinical case of chronic rheumatic heart disease that was not diagnosed during patient’s lifetime because it had been looking like cardiac arrhythmias and heart failure with tricuspid valve disease. It also discusses pathogenetic substrates of chronic rheumatic heart disease and problems in disease diagnostics when it is accompanied by tricuspid valve lesion.
Possibilities of interdisciplinary approach to early detection of asymptomatic arterial hypertension
Authors: Leshchuk T. Yu , Gelberg I. S , Kopuckij A. V
Published: January 2019

The latent form - asymptomatic form of arterial hypertension occurs in the general population in 15% to 24% of individuals, is more often associated with men, increased body mass index, smoking, stress, increased systolic blood pressure (BP), hypertrophy and diastolic dysfunction of the left ventricle and is considered the most dangerous a form of the disease that can result in sudden cardiac arrest. Early detection of risk factors for hypertension is of great preventive and economic importance. Objective - to develop a method for early detection of a high risk of developing asymptomatic hypertension with preventive digital X-ray fluorography studies and an interdisciplinary approach. Based on the screening survey conducted in 1411 workers, a method for early detection of high risk factors for asymptomatic hypertension was developed based on statistical significant risk factors. Research was conducted among workers at the workplace of 6 urban enterprises, with the detection of an enlarged left ventricle (ELV) in screening of the subject contingent and measuring BP levels. With elevated BP, 604 (42.8%) workers were identified, and with ELV - 236 (16.7%) cases. The combination of elevated BP and ELV was significantly more frequent (160, 67.8%) than with normal BP (76, 32.2%). Based on the statistical analysis, a logistic regression model with a high residual deviance (about 84%) is constructed, which gives satisfactory forecasts. The diagnostic test of the model, with cutoff threshold equal to pо=0.397, corresponds to: sensitivity - 75.5%, specificity - 64.4%, accuracy - 69.2%. Thus, the use of the screening diagnostic method in the detection of ELV in combination with age in men of 28 years or in women from 39 years of age reveals a high risk of developing asymptomatic forms of hypertension. These patients are taken to the control and sent to the physician by the therapist to perform the pre-examination.
Chronic obstructive pulmonary disease as a predictor of unfavourable prognosis in patients after myocardial revascularization
Authors: Bazdyrev E. D , Polikutina O. M , Slepynina Yu. S , Garganeeva N. P , Barbarash O. L
Published: January 2019

Purpose. We aimed to analyze the results of the annual follow-up of the patients underwent coronary artery bypass grafting (CABG) depending on the presence of concomitant respiratory diseases. Materials and methods. In a year after CABG the prognosis of 646 patients, divided into three groups, was analyzed. A criterion for the formation of the groups was the presence of chronic pulmonary pathology and obstructive ventilatory type of disorders. The first group included 46 (7.1%) patients with coronary artery disease (CAD) and respiratory disease without the signs of obstructive disorder, the second group - 241 (37.3%) patients with CAD and chronic obstructive pulmonary disease (COPD) and the third - 359 (55.6%) patients with isolated CAD. Death, hospitalizations (both for cardiovascular events and respiratory diseases, non-fatal cardiovascular events, exacerbation and complications of COPD, as well as repeated revascularization procedures were evaluated as end points. Results. One year after CABG in patients with COPD the incidence of deaths, hospitalizations for acute cardiovascular events, as well as percutaneous coronary interventions was higher than in patients with isolated CAD. According to the analysis of variance, it was demonstrated that along with age, reduced myocardial systolic function and smoking, both COPD itself and the degree of bronchial obstruction are the potential risk factors for the development of fatal outcome. Conclusion. Comorbid COPD in patients with CAD is the predictor of unfavourable prognosis within a year after CABG.
A patient with arterial hypertension and a very high risk of complications: a role of a triple fixed drug combination
Authors: Larina V. N , Orlov D. A , Sidorova V. P
Published: January 2019

The article presents a clinical observation of a middle-aged patient with uncontrolled arterial hypertension and a very high cardiovascular risk. Correction of therapy in the form of adding a fixed combination of an angiotensine converting enzyme inhibitor, calcium antagonist and diuretic in maximum doses contributed to a decrease in the levels of office SBP and DBP by 24 and 16%, respectively, SBP and DBP according to daily monitoring of blood pressure - by 16%, SBP time index by 17.1%, DBP - by 37,4% and variability of SBP and DBP by 18 and 30%, respectively, as well as improved adherence to the treatment.
A relevance of a differentiated approach to glycemic goals achievement in old patients with type 2 diabetes mellitus and cardiovascular diseases
Authors: Safronova T. I
Published: January 2019

Today patient’ self-monitoring of blood glucose is considered one of the main components in the management of diabetes mellitus. The article deals with possibilities of modern means for glycemia self-monitoring.
Mitochondrial stress response triggered by defects in protein synthesis quality control
Authors: Richter Uwe , Ng Kah Ying , Suomi Fumi , Marttinen Paula , Turunen Taina , Jackson Christopher , Suomalainen Anu , Vihinen Helena , Jokitalo Eija , Nyman Tuula A , Isokallio Marita A , Stewart James B , Mancini Cecilia , Brusco Alfredo , Seneca Sara , Lombès Anne , Taylor Robert W , Battersby Brendan J
Published: January 2019

Mitochondria have a compartmentalized gene expression system dedicated to the synthesis of membrane proteins essential for oxidative phosphorylation. Responsive quality control mechanisms are needed to ensure that aberrant protein synthesis does not disrupt mitochondrial function. Pathogenic mutations that impede the function of the mitochondrial matrix quality control protease complex composed of AFG3L2 and paraplegin cause a multifaceted clinical syndrome. At the cell and molecular level, defects to this quality control complex are defined by impairment to mitochondrial form and function. Here, we establish the etiology of these phenotypes. We show how disruptions to the quality control of mitochondrial protein synthesis trigger a sequential stress response characterized first by OMA1 activation followed by loss of mitochondrial ribosomes and by remodelling of mitochondrial inner membrane ultrastructure. Inhibiting mitochondrial protein synthesis with chloramphenicol completely blocks this stress response. Together, our data establish a mechanism linking major cell biological phenotypes of AFG3L2 pathogenesis and show how modulation of mitochondrial protein synthesis can exert a beneficial effect on organelle homeostasis.
Спектры КР молекулярных кристаллов с сильными водородными связями N—H⋯N в интервале температур 5–300 K
Authors: Галкина Ю.А. , Вершинин М.А. , Колесов Б.А.
Published: January 2019

В работе проводилось измерение спектров КР кристаллов соединений с водородными связями N—H⋯N, допускающими протонную таутомерию. Спектры получены в интервале температур 5—300 K. Температурная зависимость положения максимума трансляционных колебаний N⋯N водородных связей позволяет определить температуру начала процесса туннелирования протонов на связях, а зависимость полуширины — начала процесса упорядочения протонов. Оба параметра протонного таутомеризма коррелируют с типом и силой водородной связи.
Исследование частотной дисперсии коэффициента удельной электропроводности водных растворов электролитов
Authors: Одинаев С. , Акдодов Д.М. , Идибегзода Х.И.
Published: January 2019

На основе аналитических выражений динамического коэффициента удельной электропроводности σ(ω) и динамического модуля электроупругости ε(ω), полученных методом кинетических уравнений при определенном выборе потенциальной энергии взаимодействия между структурными единицами раствора Φab(r) и равновесной радиальной функции распределения gab(r), проведен численный расчет коэффициентов трения βa и βb, определены времена релаксации τa, τb и τab, а также ε(ω) и σ(ω) для водных растворов LiCl, NaCl, KCl и CsCl в зависимости от концентрации с, плотности ρ и температуры T в широком интервале частот ω. Полученные теоретические данные приведены в виде таблиц и графиков, а также сравнены с экспериментальными результатами, которые находятся в удовлетворительном согласии.
Improving Webpage Access Predictions Based on Sequence Prediction and PageRank Algorithm
Authors: Thon Nguyen Da , T Tan Hanh , Hoang Pham Duy
Published: January 2019

Aim/Purpose: In this article, we provide a better solution to Webpage access prediction. In particularly, our core proposed approach is to increase accuracy and efficiency by reducing the sequence space with integration of PageRank into CPT+.

Background: The problem of predicting the next page on a web site has become significant because of the non-stop growth of Internet in terms of the volume of contents and the mass of users. The webpage prediction is complex because we should consider multiple kinds of information such as the webpage name, the contents of the webpage, the user profile, the time between webpage visits, differences among users, and the time spent on a page or on each part of the page. Therefore, webpage access prediction draws substantial effort of the web mining research community in order to obtain valuable information and improve user experience as well.

Methodology: CPT+ is a complex prediction algorithm that dramatically offers more accurate predictions than other state-of-the-art models. The integration of the importance of every particular page on a website (i.e., the PageRank) regarding to its associations with other pages into CPT+ model can improve the performance of the existing model.

Contribution: In this paper, we propose an approach to reduce prediction space while improving accuracy through combining CPT+ and PageRank algorithms. Experimental results on several real datasets indicate the space reduced by up to between 15% and 30%. As a result, the run-time is quicker. Furthermore, the prediction accuracy is improved. It is convenient that researchers go on using CPT+ to predict Webpage access.

Findings: Our experimental results indicate that PageRank algorithm is a good solution to improve CPT+ prediction. An amount of though approximately 15 % to 30% of redundant data is removed from datasets while improving the accuracy.

Recommendations for Practitioners: The result of the article could be used in developing relevant applications such as Webpage and product recommendation systems.

Recommendation for Researchers: The paper provides a prediction model that integrates CPT+ and PageRank algorithms to tackle the problem of complexity and accuracy. The model has been experimented against several real datasets in order to show its performance.

Impact on Society: Given an improving model to predict Webpage access using in several fields such as e-learning, product recommendation, link prediction, and user behavior prediction, the society can enjoy a better experience and more efficient environment while surfing the Web.

Future Research: We intend to further improve the accuracy of webpage access prediction by using the combination of CPT+ and other algorithms.
IJELL Volume 15, 2019 – Table of Contents
Authors: Sudweeks Fay
Published: January 2019

Table of Contents of the Interdisciplinary Journal of E-Skills and Lifelong Learning
A CONCEPTUAL ANALYSIS OF CORPORATE GOVERNANCE AND ITS ENFORCEMENT
Authors: KANDEMİR Hatice Kübra
Published: January 2019

Reducing agency costs is the principal problem of corporate governance. Although the scope and stringency of the laws and rules on eliminating agency costs are expanding, there is stillneed for the understanding of the supervision and enforcement of these rules. Enforcement can take the forms of public and/or private. With dispersed and concentrated ownership patterns, the relevance of public and private enforcement mechanism may differ; due to the appearance of agency problems unlikely. The purpose of this paper is to provide a conceptual analysis on corporate governance strategies involving the exercise of control rights, the appointment of independent directors, auditing, and disclosure. This paper will also include a guideline on the enforcement mechanism in Turkey and the ways in which they are used to control the agency problems; between owners and managers, controlling shareholders and non-controlling shareholders or creditors.
A debreceni Kossuth Lajos Tudományegyetem archontológiája 1950–1990 XII. rész
Authors: Mudrák József
Published: January 2019

The Archontology of Lajos Kossuth University of Arts and Sciences (1950–1990), Part XII : Teacher Training Gramm ar School and Teacher Training Primary School. The Archontology of Kossuth University for the School of Arts, the School of Sciences, and for the so-called „Central Units” between January 1, 1950, and December 31, 1990, was compiled on the basis of the personal cards and personal files of the Personnel Department of the Rector’s Office, and the scantily documented section for the 1950s was supplemented from the annually arranged documentary material of the Personnel Office. Even so, however, the existing material fails to be complete. It is impossible to compile the archontology with perfect accuracy. Part XII presents the complete list pertaining to the teacher training grammar school and teacher training elementary school.
EKSTRAK DAUN SEMBUNG (Blumea balsamifera) MEMPERBAIKI HISTOLOGI TESTIS TIKUS WISTAR YANG DIINDUKSI PAKAN TINGGI LEMAK
Authors: Widhiantara I Gede , Permatasari Anak Agung Ayu Putri , Siswanto Ferbian Milas , Dewi Ni Putu Eny Sulistya
Published: January 2019

Sembung (Blumea balsamifera) Leaf Extract Improves Testis Histology of High-Fat Diet-Induced RatsABSTRACTHigh fat and high cholesterol diet cause hyperlipidemia, leading to various health problems including reproductive health. The purpose of this study was to examine the effect of sembung (Blumea balsamifera) leaf extract on testicular histology profile of high-fat-diet-induced wistar. This research used 16 adult male rats (Rattus norvegicus), aged 3-4 month, weighing 150-200 g, and randomly divided into two groups. Eight rats were treated with distilled water and eight rats were treated with 2 mg/mL B. balsamifera extract. High-fat diet was a 30 days of porcine fat feed. The results showed that the diameter of seminiferous tubules, the number of spermatogenic cells of spermatogonium A, spermatocytes Pakiten and spermatid 16 were increased by giving sembung leaf extract for 50 days (p <0.05). These results suggested that the sembung leaf extract improves testis histology of high-fat diet-induced rats. Keywords: high-fat diet, rat, sembung leaf, seminiferous tubules, spermatogenic cellsABSTRAKMakanan tinggi lemak dan tinggi kolestrol menyebabkan hiperlipidemia yang menimbulkan masalah pada sistem reproduksi. Penelitian ini bertujuan untuk mengetahui manfaat pemberian ekstrak daun sembung (Blumea balsamifera) terhadap profil tubulus seminiferus dan sel-sel spermatogenik pada tikus wistar yang diinduksi pakan tinggi lemak. Sebanyak 16 ekor tikus wistar jantan dewasa (Rattus norvegicus) umur 3-4 bulan, berat 150-200 g, secara random dibagi dua kelompok, yaitu 8 ekor tikus kelompok kontrol (aquades steril) dan 8 ekor tikus kelompok perlakuan (ekstrak daun sembung dosis 2 mg/mL). Tikus diinduksi pakan tinggi lemak berupa lemak babi selama 30 hari. Pada prettest dilakukan pemeriksaan diameter tubulus seminiferus dan sel-sel spermatogenik. Hasil penelitian menunjukkan bahwa rata-rata diameter tubulus seminiferus tikus meningkat signifikan setelah pemberian ekstrak daun sembung. Peningkatan secara signifikan juga diikuti oleh spermatogonium A, spermatosit Pakiten dan spermatid 16 (p<0,05). Dapat disimpulkan bahwa ekstrak daun sembung memperbaiki histologi testis tikus wistar yang diinduksi pakan tinggi lemak.Kata Kunci: daun sembung, pakan tinggi lemak, sel spermatogenik, tikus, tubulus seminiferus
EVALUASI AKTIVITAS INHIBISI XANTIN OKSIDASE DAN KANDUNGAN SENYAWA POLIFENOL DARI EKSTRAK SAPPAN
Authors: Ningsih Sri , Churiyah .
Published: January 2019

Evaluation of xanthine oxidase inhibitory activity and polyphenolic content of sappan extractABSTRACTHyperuricemia is a disease that is characterized by a high uric acid level, in which the number of patients tends to increase every year. This research was intended to evaluate the xanthine oxidase (XO) inhibitory activity and determinate the total polyphenol content of heartwood sappan (Caesalpinia sappan L.) extract. The extract was prepared by macerating the dry powder wood using 70% ethanol at room temperature. The quality of ethanolic extract obtained was evaluated based on BPOM guideline. XO inhibitory power was determined by measuring uric acid produced in the xanthine/XO system in vitro. The polyphenol content of the extract was measured using Folin-Ciocalteu reagent spectrophotometrically. The results showed that the quality of sappan semisolid extract fulfilled the required standard. Sappan extract inhibited XO activity by 98% relative to the positive control, allopurinol, at the final extract concentration of 100 µg/mL. The total polyphenol content was 26% of the crude extract. It could be concluded that sappan ethanolic extract has the potential to be developed as an ingredient for hyperuricemia treatment.Keywords: hyperuricemia, sappan, total polyphenol, xanthine, xanthine oxidase ABSTRAKHiperurisemia adalah penyakit yang dicirikan dengan kadar asam urat tinggi dimana prevalensi penderita cenderung meningkat. Penelitian ini bertujuan untuk mempelajari aktivitas esktrak kayu sappan (Caesalpinia sappan L.) dalam menginhibisi enzim XO (xantin oksidase) secara in vitro dan penentuan kadar senyawa polifenol total yang terkandung di dalamnya. Ekstrak dibuat dengan cara maserasi serbuk kayu menggunakan pelarut etanol 70% pada suhu kamar. Kualitas ekstrak dievaluasi mengacu pada parameter karakterisasi ekstrak yang ditetapkan oleh BPOM. Aktivitas inhibisi XO ditetapkan dengan mengukur kadar asam urat yang terbentuk pada sistem xantin/XO in vitro. Kadar polifenol ekstrak diukur menggunakan pereaksi Folin-Ciocalteu secara spektrofotometri. Hasil analisis menyatakan bahwa kualitas ekstrak kental sappan memenuhi persyaratan yang ada. Pengujian inhibisi XO dengan pembanding positif allopurinol pada konsentrasi akhir ekstrak sebesar 100 µg/mL menunjukkan bahwa ekstrak mempunyai kekuatan menginhibisi XO sebesar 98% relatif terhadap pembanding positif allopurinol. Kadar senyawa polifenol total dalam ekstrak sappan sebesar 26% dari ekstrak kasar. Dari penelitian ini dapat disimpulkan bahwa ekstrak sappan mempunyai potensi untuk dikembangkan sebagai bahan untuk mengatasi hiperurisemia.Kata Kunci: hiperurisemia, polifenol total, sappan, xantin, xantin oksidase
VARIASI GENETIK KAMBING BENGGALA DI KABUPATEN MANGGARAI BARAT BERDASARKAN METODE RANDOM AMPLIFIED POLYMORPHIC DNA
Authors: Pakpahan Suhendra , Artama Wayan Tunas , Widayanti Rini , Budisatria I Gede Suparta
Published: January 2019

Genetic Variation of Benggala Goats in West Manggarai Regency Based on Random Amplified Polymorphic DNA Method ABSTRACTIndonesia has several types of local goats that have had an extended period of adaptation to the natural conditions in Indonesia. Goat is one of the most important germplasm in supporting the economy of rural communities. Benggala is a local breed of goat originating from Flores Island, East Nusa Tenggara province and has distinctive characteristics. The RAPD technique has several advantages and has been widely used in studies of the genetic diversity of goats. A total of 50 blood samples of Benggala goats were taken from four sub-districts in West Manggarai Regency. This study was conducted to estimate genetic variations of Benggala goats using OPA-6 and OPA-16 primers. The OPA-6 primer consisted of 0-11 bands, while the OPA-16 primer consisted of 0-7 bands. The total bands produced on the OPA-6 primer from all samples was 456, whilst OPA-16 primer was 314. The lowest genetic similarity between individuals of Benggala goats was 44% from the sample K46. Based on the sample population, the average genetic similarity level was 72%. These results show that the genetic diversity of Benggala goats is low.Keywords: Benggala  goat, genetic similarity,genetic variation, RAPD, West Manggarai ABSTRAKIndonesia memiliki beberapa jenis kambing lokal yang memiliki periode adaptasi yang panjang dengan kondisi alam di Indonesia. Kambing merupakan salah satu plasma nutfah yang sangat penting dalam mendukung perekonomian masyarakat pedesaan. Benggala adalah jenis kambing lokal yang berasal dari pulau Flores, propinsi Nusa Tenggara Timur dan kambing Benggala memiliki ciri khas. Teknik RAPD memiliki beberapa keunggulan dan telah banyak digunakan pada studi keragaman genetik kambing. Total 50 sampel darah kambing Benggala yang diambil dari empat kecamatan di Kabupaten Manggarai Barat. Penelitian ini dilakukan untuk menguji variasi genetik kambing Benggala dengan menggunakan primer OPA-6 dan OPA-16. Primer OPA-6 terdiri dari 0-11 band, sedangkan primer OPA-16 terdiri dari 0-7 band. Total jumlah pita yang dihasilkan pada primer OPA-6 dari semua sampel adalah 456, sementara primer OPA-16 adalah 314. Kemiripan genetik terendah antara individu-individu kambing Benggala adalah 44% dari sampel K46. Berdasarkan populasi sampel, tingkat kemiripan genetik rata-rata adalah 72%. Hasil ini menunjukkan bahwa keragaman genetik kambing Benggala tergolong rendah.Kata Kunci: kambing Benggala, kemiripan genetik, Manggarai Barat , RAPD, variasi genetik
PENGARUH WADAH KULTUR DAN KONSENTRASI SUMBER KARBON PADA PERBANYAKAN KENTANG ATLANTIK SECARA IN VITRO
Authors: Karyanti Karyanti , Kristianto Yosua Glen , Khairiyah Hayat , Novita Linda , Sukarnih Tati , Rudiyana Yayan , Sofia Dewi Yustika
Published: January 2019

The Effect of Culture Container and Carbon Source Concentration on In Vitro Shoot Propagation of Atlantic PotatoABSTRACTPotato is a food commodity that has the potential to support food diversification in Indonesia. There is an increasing demand for Atlantic potatoes as the raw material for processed potato products. The demand, which has not been met by the increased production, has been the cause of the ongoing potato import activities in Indonesia. The limitation of producing quality Atlantic potato seeds economically is one of the obstacles to increasing the production of Atlantic potatoes in Indonesia. The aim of this research was to study the effect of various table sugar concentrations as the carbon source and the type of the culture containers used for Atlantic potato shoot multiplication in vitro. The propagation was carried out in bioreactors and culture bottles with MS liquid medium + coconut water at a concentration of 150 mL/L medium, and 3 concentration levels of table sugar, namely 0; 7.5; and 15 g/L medium. The use of bioreactor significantly increased the height of the Atlantic potato plantlets. The use of bioreactor combined with table sugar addition decreased hyperhydricity level. The highest number of shoots, leaves, and roots were found at the table sugar concentration of 15 g/L medium in both containers.Keywords: bioreactor, micropropagation, shoot culture, Solanum tuberosum, sucrose ABSTRAKKentang merupakan komoditas pangan yang berpotensi mendukung program diversifikasi pangan di Indonesia. Peningkatan permintaan terhadap kentang Atlantik sebagai bahan baku kentang olahan yang tak diimbangi dengan peningkatan produksi kentang Atlantik menjadi penyebab masih berlangsungnya impor kentang Atlantik di Indonesia. Keterbatasan menghasilkan benih kentang Atlantik berkualitas yang ekonomis merupakan salah satu hambatan dalam meningkatkan produksi kentang Atlantik di Indonesia. Penelitian ini bertujuan mempelajari pengaruh variasi konsentrasi sukrosa teknis sebagai sumber karbon dan penggunaan jenis wadah terhadap perbanyakkan tunas kentang Atlantik secara in vitro. Perbanyakkan tunas kentang Atlantik menggunakan media MS cair + 150 mL/L air kelapa dalam wadah bioreaktor dan botol kultur dengan 3 taraf konsentrasi sukrosa, yaitu 0; 7,5; dan 15 g/L media. Penggunaan bioreaktor secara signifikan meningkatkan tinggi planlet kentang Atlantik yang dihasilkan. Penggunaan bioreaktor yang dikombinasikan dengan penambahan sukrosa teknis menurunkan tingkat hiperhidrisitas. Tunas, daun, dan akar terbanyak dihasilkan oleh perlakuan sukrosa teknis 15 g/L media dalam kedua jenis wadah.Kata Kunci: bioreaktor, kultur tunas, mikropropagasi, Solanum tuberosum, sukrosa
DAMPAK TEKNIK PENGIRISAN DAN PENCETAKAN TERHADAP DAYA APUNG PAKAN IKAN YANG DIFERMENTASI MENGGUNAKAN Rhizopus sp.
Authors: Suliswati Lulu , Sriherwanto Catur , Suja'i Imam
Published: January 2019

Impact of Slicing and Moulding Techniques on the Floatability of the Fish Feed Fermented by Rhizopus sp.ABSTRACTThe use of Rhizopus sp. mycelium as biocoating, biostabilizing, and biofloating agent in the production of floating fish feed through solid fermentation had already been studied as a much simpler alternative to mechanical extrusion. The fermented fish feed, however, had poor floatability in aerated water, probably due to structural damage during the size reduction process of the feed. Thus, this study used alternative size-reducing methods, namely slicing and moulding, to improve the floatability of the fermented feed. Other physical characteristics were also measured and compared to those of commercial sinking and floating fish feeds. Results showed that both the moulded and the sliced fermented-feeds had lower density as well as higher water stability, absorption capacity, floatability, and durability compared to those of the commercial sinking feed used as the fermentation substrate. The hydrophobicity of all the feeds tested were similar, however. The floatability of the fermented feeds obtained in this study was much higher than those of the previous studies. Keywords: floatability, floating feed, sinking feed, water absorption, water stabilityABSTRAKPenggunaan miselium Rhizopus sp. sebagai pelapis permukaan, penstabil, dan pengapung hayati dalam pembuatan pakan ikan apung melalui fermentasi padat telah diteliti sebagai alternatif yang jauh lebih sederhana dibandingkan dengan metode ekstrusi mesin. Namun, pakan ikan fermentasi ini memiliki daya apung yang buruk dalam air bergelembung udara, yang mungkin disebabkan kerusakan struktural selama proses pengecilan ukuran pakan. Karenanya, penelitian ini menggunakan metode lain untuk mengecilkan ukuran, yakni pencetakan dan pengirisan, dalam rangka meningkatkan daya apung pakan yang difermentasi. Karakteristik fisik lainnya juga diukur dan dibandingkan dengan pakan ikan tenggelam dan terapung komersial. Hasil menunjukkan bahwa proses fermentasi serta metode pengecilan dimensi yang digunakan menghasilkan pakan yang memiliki massa jenis lebih rendah, serta stabilitas air, daya serap air, daya apung, serta ketahanan benturan lebih tinggi dibandingkan dengan pakan tenggelam komersial yang digunakan sebagai substrat fermentasi. Namun, nilai hidrofobisitas semua pakan yang diuji adalah sama. Daya apung pakan fermentasi dalam penelitian ini jauh lebih tinggi daripada penelitian sebelumnya.Kata Kunci: daya apung, daya serap air, stabilitas dalam air, pakan apung, pakan tenggelam
Realistic Mathematics Education (RME) Provides Great Benefits for Students in Indonesia
Authors: Lesnussa Yopi Andry
Published: January 2019

Mathematics as a part of basic science is considered very difficult, especially for students from elementary school to high school. To facilitate the process of learning mathematics has been developed many new learning methods by experts in mathematics education, one of them is realistic mathematics education. Realistic mathematics education is one of therenewed learning methods on basic mathematical concepts that related to the context, illustrations, and based on everyday life situations. Besides realistic mathematics education motivated students to be more active and creative in solving mathematical problems according to real conditions, it also more emphasize cooperative and communicative learning so that students are more interested in learning mathematics. This encourages the government to include realistic mathematics education in the curriculum of basic education and also through the provision of training and education for teachers. It is expected that the education system that accommodates Realistic Mathematic Education can increase the interesting of students' learning