bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplement Figures from Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase
Authors: He Xiaozhen , Yan Bin , Liu Shuang , Jia Jiantao , Lai Weiwei , Xin Xing , Tang Can-e , Luo Dixian , Tan Tan , Jiang Yiqun , Shi Ying , Liu Yating , Xiao Desheng , Chen Ling , Liu Shao , Mao Chao , Yin Gang , Cheng Yan , Fan Jia , Cao Ya , Muegge Kathrin , Tao Yongguang
Published: December 2023

Supplementary Figures Figure S1 Western blot analysis detected LSH expression a panel of NPC cells. Figure S2 Overexpression of LSH promotes cell growth, migration and invasion in vitro. Figure S3 Overexpression of LSH promotes cancer progression in vivo. Figure S4. Overexpression of LSH promotes cancer progression in vivo. Figure S5 Knockdown of LSH inhibits cancer progression in vitro and in vivo. Figure S6 FH decreased FH expression. Figure S7 LSH regulated TCA intermediates. Figure S8. EBV status was not linked with TCA intermediates. Figure S9. TCA intermediates citrate and α-KG decreased other intermediates. Figure S10. TCA intermediates succinate, fumarate and malate affected the protein levels of FH, EMT and IKKα. Figure S11. Western blot analysis detected FH expression a panel of NPC cells. Figure S12. The concentrations of α-KG and citrate were analyzed in HNE3 cells in the depletion of FH. Figure S13 Western blot analysis detected EMT markers as indicated.
Data from PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis
Authors: Samanta Debangshu , Park Youngrok , Andrabi Shaida A. , Shelton Laura M. , Gilkes Daniele M. , Semenza Gregg L.
Published: December 2023

Abstract
Intratumoral hypoxia stimulates enrichment of breast cancer stem cells (BCSC), which are critical for metastasis and patient mortality. Here we report a metabolic adaptation that is required for hypoxia-induced BCSC enrichment and metastasis. Hypoxia-inducible factors coordinately regulate expression of genes encoding phosphoglycerate dehydrogenase (PHGDH) and five downstream enzymes in the serine synthesis pathway and mitochondrial one-carbon (folate) cycle. RNAi-mediated silencing of PHGDH expression in both estrogen receptor–positive and negative breast cancer cells led to decreased NADPH levels, disturbed mitochondrial redox homeostasis, and increased apoptosis, which abrogated BCSC enrichment under hypoxic conditions. PHGDH-deficient cells exhibited increased oxidant levels and apoptosis, as well as loss of BCSC enrichment, in response to treatment with carboplatin or doxorubicin. PHGDH-deficient cells were relatively weakly tumorigenic and tumors that did form were deficient in BCSCs, abolishing metastatic capacity. Our findings highlight a role for PHGDH in the formation of secondary (recurrent or metastatic) tumors, with potential implications for therapeutic targeting of advanced cancers. Cancer Res; 76(15); 4430–42. ©2016 AACR.
Exploring the Relationship between Adherence to Therapy, Treatment Acceptability, and Clinical Outcomes in Adults with Attention-Deficit/Hyperactivity Disorder: Results from the COMPAS Multicenter Randomized Controlled Trial
Authors: López-Pinar Carlos , Rosen Helena , Selaskowski Benjamin , Staerk Christian , Jans Thomas , Retz Wolfgang , Retz-Junginger Petra , Roesler Michael , Sobanski Esther , Huss Michael , Matthies Swantje , Tebartz van Elst Ludger , Berger Mathias , Jacob Christian , Kis Bernhard , Colla Michael , Alm Barbara , Abdel-Hamid Mona , Martínez-Sanchís Sonia , Carbonell-Vayá Enrique , Lux Silke , Philipsen Alexandra
Published: December 2023

Introduction: Cognitive behavioral therapy and dialectical behavior therapy (DBT) can be effective in treating adults with ADHD, and patients generally consider these interventions useful. While adherence, as measured by attendance at sessions, is mostly sufficient, adherence to therapy skills has not been assessed. Furthermore, the relationship between patient evaluation of therapy effectiveness, treatment adherence, and clinical outcomes is understudied. Objective: This study aimed to examine treatment acceptability and adherence in relation to treatment outcomes in a large randomized controlled trial comparing a DBT-based intervention with a nonspecific active comparison, combined with methylphenidate or placebo. Method: A total of 433 adult patients with ADHD were randomized. Participants reported how effective they found the therapy, and adherence was measured by attendance at therapy sessions and by self-reports. Descriptive, between-groups, and linear mixed model analyses were conducted. Results: Participants rated psychotherapy as moderately effective, attended 78.40–94.37% of sessions, and used skills regularly. The best-accepted skills were sports and mindfulness. Groups receiving placebo and/or nonspecific clinical management rated their health condition and the medication effectiveness significantly worse than the psychotherapy and methylphenidate groups. Improvements in clinical outcomes were significantly associated with treatment acceptability. Subjective (self-reported) adherence to psychotherapy was significantly associated with improvements in ADHD symptoms, clinical global efficacy and response to treatment. Discussion: These results further support the acceptability of DBT for adult ADHD and suggest the need to address adherence to treatment to maximize clinical improvements. Results may be limited by the retrospective assessment of treatment acceptability and adherence using an ad hoc instrument.
The Impact of Medium Cut-Off Dialyzers on Malnutrition-Inflammation Scores in Maintenance Hemodialysis Patients
Authors: Sahutoglu Tuncay , Erinc Osman , Avsar Fevzi Necati
Published: December 2023

Introduction: Medium cut-off (MCO) membranes may be able to remove middle-large uremic toxins that are retained in the body, which has been linked to various risk factors including malnutrition-inflammation score (MIS). The effect of MCO dialyzers on MIS has been studied. Methods: This single-center exploratory prospective observational study enrolled maintenance hemodialysis patients who underwent dialysis using either MCO (Theranova 400) or high-flux (FX80) membranes as part of their regular care. Measurements of MIS, body weight, height, body mass index, and various biochemical markers were taken at the beginning and conclusion of the study. Results: This study included 50 patients who were treated with either the Theranova 400 (n = 25) or the FX80 (n = 25) for a period of 6 months. The two groups were similar in terms of demographics, duration of hemodialysis treatment, and baseline biochemical test results. Theranova 400 had no significant impact on the median MIS (6 [6–10] vs. 7 [5-10], p 0.575) and serum albumin levels (4.07 [3.92–4.22] vs. 4.04 [3.85–4.30], p 0.689), while the FX80 resulted in a significant increase in MIS (6 [5–8] vs. 8 [6–10], p 0.033) and a significant decrease in serum albumin levels (4.23 [4.03–4.36] vs. 3.98 [3.77–4.12], p 0.027) at the end of the study. Discussion/Conclusion: After 6 months of treatment, the MCO dialyzer did not demonstrate a statistically significant difference in the MIS when compared to the high-flux dialyzer. However, MIS worsening was significantly less in the MCO group, indicating the potential benefits of MCO membranes in maintaining nutritional status. Further research is required to validate these results.
Associations between Total Immunoglobulin E Levels and Urinary Albumin Excretion: A Cross-Sectional Study
Authors: Yang Fan , Zhu Baoping , Liu Ye , Bai Haitao
Published: December 2023

Introduction: The association between total immunoglobulin E (IgE) levels and urinary albumin excretion has not been fully established. Current study aimed to evaluate the association between total IgE levels and urinary albumin-to-creatinine ratio (UACR) among adult Americans. Methods: Current cross-sectional study utilized data from the 2005 to 2006 National Health and Nutrition Examination Survey, including individuals aged 20 years and above. To assess the relationships between total IgE levels and UACR, both multivariable linear regression models and smooth curve fitting were employed. Results: The study included a total of 3,400 participants (weighted mean age: 46.6 ± 0.8 years), with 1,625 females (weighted percentage: 47.8%). After adjusting for potential confounders, we observed a positive association between higher total IgE levels on a log2 scale and increased UACR (β = 3.34; 95% CI: 1.40–5.28, p = 0.002). Furthermore, the association displayed a non-linear dose-response pattern. The interaction test revealed a significant distinction in the correlation between total IgE and UACR when stratified by hyperlipidemia (p for interaction <0.001). The results remained robust in sensitivity analyses. Conclusion: Our study revealed a significant and independent association between elevated total IgE levels and an increased UACR, which also exhibited a distinct non-linear pattern, highlighting the intricate nature of the connection between IgE levels and UACR.
Representaciones sociales infantiles de la pandemia: dos años después de su inicio
Authors: Sabat Agurto Catalina , Novoa Rivera Consuelo , Quijada Yanet , Galdames Riquelme Alejandra , Díaz-Meléndez Paula , Spaudo Valenzuela Paulina , Zamorano Latorre Rodrigo
Published: December 2023

(analytical)Children's beliefs and attitudes towards the Covid-19 pandemic have been studied mainly in the most critical socio-sanitary period and from an adult-centric perspective. To address this problem, aphenomenological study was carried out that used content and thematic analysis of drawings of 16participants from 7 to 8 years of age, to describe children's social representations of the pandemic.The results highlighted emotions of fear, sadness and boredom, associated with the feeling of loneliness. The house was also identified as a safe space in the face of environmental threats, lack of interactionwith others, a feeling of being trapped, and lack of behavioral control. Two years after the start of the pandemic, these findings suggest the need to implement action plans for child welfare based on children's rights.
Brasil, China e Índia nas cadeias globais de valor da indústria farmacêutica
Authors: Ouriques Helton Ricardo , Rodrigues Daniela Santos Nunes de
Published: December 2023

O presente artigo tem como objetivo principal analisar a evolução da participação de China, Índia e Brasil nas cadeias globais de fármacos e como o desenvolvimento de suas respectivas indústrias farmacêuticas impactou seu posicionamento durante a pandemia de Covid-19. O objeto desta pesquisa serão as políticas de Estado executadas de modo a desenvolver o setor de fármacos nos países analisados, bem como os impactos para a sua inserção internacional entre 1980 e 2022. O artigo adota o instrumental de análise das cadeias globais de valor, que explicita a divisão dos processos produtivos através de diferentes Estados e a concentração da produção de ativos intangíveis de alto valor agregado (como tecnologia e propriedade intelectual) em nódulos (países) importantes de determinada cadeia. Neste sentido, propomos como perguntas de pesquisa: como ocorre a inserção de China, Índia e Brasil nas cadeias globais de valor neste setor? Quais os nódulos que conseguiram ocupar? A resposta destas perguntas possibilita-nos avaliar se a inserção internacional desses países se deu de forma subordinada ou com maior grau de autonomia e governança nas cadeias de fármacos. Por fim, será realizada uma análise de como o desenvolvimento da indústria farmacêutica dos países selecionados impactou seu posicionamento em relação à indústria farmacêutica global.
Desvendando Esse Cabelo, de Djaimilia Pereira de Almeida: uma proposta de ensino de literatura
Authors: Vieira Celiane da Silva , Gonçalves de Souza Santos Natália
Published: December 2023

A partir do estudo da obra Esse Cabelo (2015) de Djaimilia Pereira de Almeida e da teoria literária e social pertinente a esse texto literário, este trabalho pretende oferecer aos educadores um referencial de sequência didática para o ensino do romance, estruturado com base na proposta de Dolz, Noverraz e Schneuwly (2004), e em uma perspectiva de ensino de literatura que combina o paradigma analítico-textual com o paradigma social-identitário, sistematizados por Cosson (2020).
Condições de nascimento de filhos de mulheres vivendo com HIV
Authors: Soares Milena da Silva , Barros Ezequiel Almeida , Ferreira e Silva Janainna , Santos Romila Martins de Moura Stabnow , Costa Ana Cristina Pereira de Jesus , Pascoal Livia Maia , Santos Neto Marcelino , Santos Floriacy Stabnow
Published: December 2023

Objetivou-se identificar as condições de nascimento de filhos de mulheres vivendo com HIV no período compreendido entre 2009 e 2019, no Hospital Regional Materno Infantil de Imperatriz (MA). Estudo transversal, quantitativo, documental, com análise descritiva dos dados e realizado em maternidade de referência entre os meses de agosto de 2020 e julho de 2021. Incluíram-se informações dos prontuários das gestantes soropositivas para HIV e de seusfilhos recém-nascidos. Os resultados levantaram 314 prontuários, destes, 195 eram elegíveis. Sobre as condições de nascimento dos recém-nascidos, em 56,41% o teste rápido foi negativo; 72,82% usaram profilaxia pós-nascimento; 75,38% não receberam leite materno; 68,2% receberam vacinas logo ao nascer; 40,51% não faziam uso de nenhuma medicação; 20,51% das mães tinham entre 36 a 40 anos; 59,48% não residiam no município pesquisado;23,6% eram donas de casa; 65,64 eram multigestas; 46,15% receberam o diagnóstico de HIV na gestação;67,17% não tinham coinfecções; 82,05% realizaram o pré-natal; 60,51% fizeram uso da profilaxia intraparto; e 77,43% fizeram cesariana. O acompanhamento no pré-natal e parto da maioria dessas mulheres vivendo com HIV refletiu positivamente nas condições de nascimento de seus filhos, sendo uma importante estratégia, visando a não transmissão vertical e prevenção da doença nas crianças.
Capacidade funcional e qualidade de vida de adultos e idosos com feridas crônicas
Authors: Mota Letícia Eugênio , Nunes Maria Gabriella Campos , Barbosa Thallita Claucia Moraes , Goulart Jessica , Oliveira-Cortez Andreza , Lanza Fernanda Moura , Moraes Juliano Teixeira , Cortez Daniel Nogueira
Published: December 2023

Introdução: As feridas crônicas afetam a população em geral e comprometem negativamente a qualidade de vida e geram impactos biopsicossociais. Objetivo: Analisar a associação entre a capacidade funcional e a qualidade de vida de adultos e idosos com feridas crônicas. Métodos: Estudo transversal com 135 acometidas por feridas crônicas cadastradas nos serviços de atenção primária à saúde de um município de Minas Gerais, Brasil. Para a coleta dedados realizada no período de 2017 a 2018, utilizaram-se os instrumentos i) Cardiff Wound Impact Schedule que foi traduzido, adaptado culturalmente e validado para a língua portuguesa do Brasil; ii) Índice de Katz e iii) questionáriosociodemográfico com informações sobre o perfil de saúde/doença e características das feridas. Resultados: Houve predomínio de participantes do sexo feminino (59,3%), com idade acima de 60 anos (70,4%) e até 4 anos de estudo (72,6%). No questionário Cardiff Wound Impact Schedule, o domínio com menor pontuação foi o debem-estar (média 45,6 ± 18,2). Na avaliação da funcionalidade realizada por meio do Índice de Katz, destaca-se que 30 (22,2%) pessoas foram consideradas dependentes para tomar banho e 33 (24,4%) necessitavam de ajuda para se locomover. Houve associação estatisticamente significativa entre as seguintes variáveis independentes do Índice de Katz e do Cardiff Wound Impact Schedule para “vida social” e “banho”, “vida social” e “vestir-se”, “vidasocial” e “higiene pessoal”, “vida social” e “locomoção”, “vida social” e “alimentação”, “sintomas físicos e vida diária” e “vestir-se”, “bem-estar” e “continência”. Conclusão: A incapacidade funcional está associada à diminuição da qualidade de vida de adultos e idosos com feridas crônicas.
Estado nutricional de gestantes adolescentes assistidas pela Atenção Básica: um estudo de série temporal com dados do estado de Minas Gerais
Authors: Moreira Julia Chagas , Lacerda Letícia Francisco Ferreira , Della Torre Ana Clara da Cruz , Brito Tábatta Renata Pereira de , Teixeira Lílian Gonçalves , Lima Daniela Braga
Published: December 2023

Estudo ecológico, de série temporal, que teve como objetivo analisar a tendência do estado nutricional de gestantes adolescentes assistidas pela atenção primária à saúde em Minas Gerais. Os dados foram provenientes do Sistema de Vigilância Alimentar e Nutricional, referente ao estado nutricional de 140.969 gestantes adolescentes entre os anos de 2010 a 2019; apresentados em variação percentual anual por meio da regressão linear simples. O baixo peso mostrou tendência decrescente nas macrorregiões Sul e Triângulo do Norte com variaçãoanual de -0,88% (IC95% -1,67; -0,09) e -0,79% (IC95% -1,06; -0,51) e o excesso de peso registrou tendênciacrescente nas macrorregiões Nordeste, Noroeste, Norte, Triângulo do Sul e Vale do Aço com a variação anual de 0,28% (IC95% 0,04;0,52), 0,37% (IC95% 0,23;0,51), 0,64% (IC95% 0,32;0,95), 0,44% (IC95% 0,18;0,70) e 0,57% (IC95% 0,26;0,88), respectivamente. Conclui-se que, no período avaliado, houve a tendência de aumento do excesso de peso entre as gestantes adolescentes no estado de Minas Gerais, acompanhando o processo detransição nutricional no país.
Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome
Authors: Flemming Kelly D. , Kim Helen , Hage Stephanie , Mandrekar Jay , Kinkade Serena , Girard Romuald , Torbey Michel , Huang Judy , Huston John , Shu Yunhong , Lanzino Giuseppe , Selwyn Reed , Hart Blaine , Mabray Marc , Feghali James , Sair Haris I. , Narvid Jared , Lupo Janine M. , Lee Justine , Stadnik Agnieszka , Alcazar-Felix Roberto J. , Shenkar Robert , Lane Karen , McBee Nichole , Treine Kevin , Ostapkovich Noeleen , Wang Ying , Thompson Richard , Koenig James I. , Carroll Timothy , Hanley Daniel , Awad Issam
Published: December 2023

BACKGROUND:

Cerebral cavernous malformation with symptomatic hemorrhage (SH) are targets for novel therapies. A multisite trial-readiness project (
https://www.clinicaltrials.gov
; Unique identifier: NCT03652181) aimed to identify clinical, imaging, and functional changes in these patients.

METHODS:

We enrolled adult cerebral cavernous malformation patients from 5 high-volume centers with SH within the prior year and no planned surgery. In addition to clinical and imaging review, we assessed baseline, 1- and 2-year National Institutes of Health Stroke Scale, modified Rankin Scale, European Quality of Life 5D-3 L, and patient-reported outcome-measurement information system, Version 2.0. SH and asymptomatic change rates were adjudicated. Changes in functional scores were assessed as a marker for hemorrhage.

RESULTS:

One hundred twenty-three, 102, and 69 patients completed baseline, 1- and 2-year clinical assessments, respectively. There were 21 SH during 178.3 patient years of follow-up (11.8% per patient year). At baseline, 62.6% and 95.1% of patients had a modified Rankin Scale score of 1 and National Institutes of Health Stroke Scale score of 0 to 4, respectively, which improved to 75.4% (
P
=0.03) and 100% (
P
=0.06) at 2 years. At baseline, 74.8% had at least one abnormal patient-reported outcome-measurement information system, Version 2.0 domain compared with 61.2% at 2 years (
P
=0.004). The most common abnormal European Quality of Life 5D-3 L domains were pain (48.7%), anxiety (41.5%), and participation in usual activities (41.4%). Patients with prospective SH were more likely than those without SH to display functional decline in sleep, fatigue, and social function patient-reported outcome-measurement information system, Version 2.0 domains at 2 years. Other score changes did not differ significantly between groups at 2 years. The sensitivity of scores as an SH marker remained poor at the time interval assessed.

CONCLUSIONS:

We report SH rate, functional, and patient-reported outcomes in trial-eligible cerebral cavernous malformation with SH patients. Functional outcomes and patient-reported outcomes generally improved over 2 years. No score change was highly sensitive or specific for SH and could not be used as a primary end point in a trial.
Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling
Authors: Hage Stephanie , Kinkade Serena , Girard Romuald , Flemming Kelly D. , Kim Helen , Torbey Michel T. , Huang Judy , Huston John , Shu Yunhong , Selwyn Reed G. , Hart Blaine L. , Mabray Marc C. , Feghali James , Sair Haris I. , Narvid Jared , Lupo Janine M. , Lee Justine , Stadnik Agnieszka , Alcazar-Felix Roberto J. , Shenkar Robert , Hobson Nicholas , DeBiasse Dorothy , Lane Karen , McBee Nichole A. , Treine Kevin , Ostapkovich Noeleen , Wang Ying , Thompson Richard E. , Koenig James I. , Carroll Timothy , Hanley Daniel F. , Awad Issam A.
Published: December 2023

BACKGROUND:

Quantitative susceptibility mapping (QSM) and dynamic contrast-enhanced quantitative perfusion (DCEQP) magnetic resonance imaging sequences assessing iron deposition and vascular permeability were previously correlated with new hemorrhage in cerebral cavernous malformations. We assessed their prospective changes in a multisite trial-readiness project.

METHODS:

Patients with cavernous malformation and symptomatic hemorrhage (SH) in the prior year, without prior or planned lesion resection or irradiation were enrolled. Mean QSM and DCEQP of the SH lesion were acquired at baseline and at 1- and 2-year follow-ups. Sensitivity and specificity of biomarker changes were analyzed in relation to predefined criteria for recurrent SH or asymptomatic change. Sample size calculations for hypothesized therapeutic effects were conducted.

RESULTS:

We logged 143 QSM and 130 DCEQP paired annual assessments. Annual QSM change was greater in cases with SH than in cases without SH (
P
=0.019). Annual QSM increase by ≥6% occurred in 7 of 7 cases (100%) with recurrent SH and in 7 of 10 cases (70%) with asymptomatic change during the same epoch and 3.82× more frequently than clinical events. DCEQP change had lower sensitivity for SH and asymptomatic change than QSM change and greater variance. A trial with the smallest sample size would detect a 30% difference in QSM annual change during 2 years of follow-up in 34 or 42 subjects (1 and 2 tailed, respectively); power, 0.8, α=0.05.

CONCLUSIONS:

Assessment of QSM change is feasible and sensitive to recurrent bleeding in cavernous malformations. Evaluation of an intervention on QSM percent change may be used as a time-averaged difference between 2 arms using a repeated measures analysis. DCEQP change is associated with lesser sensitivity and higher variability than QSM. These results are the basis of an application for certification by the US Food and Drug Administration of QSM as a biomarker of drug effect on bleeding in cavernous malformations.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03652181.
Increasing Activity After Stroke: A Randomized Controlled Trial of High-Intensity Walking and Step Activity Intervention
Authors: Thompson Elizabeth D. , Pohlig Ryan T. , McCartney Kiersten M. , Hornby T. George , Kasner Scott E. , Raser-Schramm Jonathan , Miller Allison E. , Henderson Christopher E. , Wright Henry , Wright Tamara , Reisman Darcy S.
Published: December 2023

BACKGROUND:

Physical inactivity in people with chronic stroke profoundly affects daily function and increases recurrent stroke risk and mortality, making physical activity improvements an important target of intervention. We compared the effects of a high-intensity walking intervention (FAST), a step activity monitoring behavioral intervention (SAM), or a combined intervention (FAST+SAM) on physical activity (ie, steps/day). We hypothesized the combined intervention would yield the greatest increase in steps/day.

METHODS:

This assessor-blinded multisite randomized controlled trial was conducted at 4 university/hospital-based laboratories. Participants were 21 to 85 years old, walking without physical assistance following a single, unilateral noncerebellar stroke of ≥6 months duration, and randomly assigned to FAST, SAM, or FAST+SAM for 12 weeks (2–3 sessions/week). FAST training consisted of walking-related activities at 70% to 80% heart rate reserve, while SAM received daily feedback and goal setting of walking activity (steps/day). Assessors and study statistician were masked to group assignment.

The a priori–determined primary outcome and end point was a comparison of the change in steps/day between the 3 intervention groups from pre- to post-intervention. Adverse events were tracked after randomization. All randomized participants were included in the intent-to-treat analysis.

RESULTS:

Participants were enrolled from July 18, 2016, to November 16, 2021. Of 2385 participants initially screened, 250 participants were randomized (mean [SE] age, 63 [0.80] years; 116 females/134 males), with 89 assigned to FAST, 81 to SAM, and 80 to FAST+SAM. Steps/day significantly increased in both the SAM (mean [SE], 1542 [267; 95% CI, 1014–2069]
P
<0.001) and FAST+SAM group (1307 [280; 95% CI, 752–1861]
P
<0.001) but not in the FAST group (406 [238; 95% CI, −63 to 876]
P
=0.09). There were no deaths or serious study-related adverse events.

CONCLUSIONS:

Only individuals with chronic stroke who completed a step activity monitoring behavioral intervention with skilled coaching and goal progression demonstrated improvements in physical activity (steps/day).

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02835313.
Sexting, Self-esteem, and Social Media: A Comparison among Frequent, Occasional, and Non-sexting Italian Adolescent Girls
Authors: Verrastro Valeria , Saladino Valeria , Eleuteri Stefano , Barberis Nadia , Cuzzocrea Francesca
Published: December 2023

Background. The phenomenon of sexting consists of sending and sharing sexual images, videos, or messages using smartphones and social networks. Sexting is spreading dangerously among adolescents who share private and explicit sexual content, ignoring the negative and risky consequences associated with this behavior. According to recent literature, sexting behavior is strongly related to the participants’ level of self-esteem and social media’s influence on them. Objective. Our study was a descriptive community-based study focused on the central-south Italian context, which aimed to investigate sexually risky behavior and the main motivations for sexting, and to compare differences in self-esteem and social media’s influence among three groups of Italian girls: non-sexters, occasional sexters, and frequent sexters. Design. Our research involved 569 Italian girls (14–19 years old) who completed the following questionnaires: the Questionnaire on Health and Sexual Behavior; the Sexting Behavior Scale; the Multidimensional Self-Concept Scale; and the Sociocultural Attitudes Toward Appearance Questionnaire-3. Results. Our results showed that most participants sexted with their partner, and had a responsible attitude toward sexuality and kept sexual risk low. Moreover, frequent sexters had higher scores on social media’s influence relative to the internalization of the body image and model for beauty and athleticism, as well as lower levels of global, academic, and competence self-esteem. Conclusion. Our results could promote interventions in the school context in order to: a) improve awareness among youth about social media use, sexting, and safe sexuality; b) reduce the risk associated with sexting and the influence of social networks; and c) stimulate reflections by teachers and parents on adolescents’ sense of identity and self-esteem.
The Relationship of Mobile-Based Social Network Addiction and Family Communication Patterns, with Behavioral Problems in Secondary School Students: The Mediating Role of Emotional Self-Regulation
Authors: Fasihi Mohadeseh , Rostami Mohammad
Published: December 2023

Background. New technologies offer endless possibilities for students and schools, but as the use of smartphones increases, psychological and behavioral problems may also increase. Objective. To investigate the relationship of mobile-based social network addiction and family communication patterns on the one hand, and behavioral problems in students on the other, with a focus on the mediating role of emotional self-regulation. Design. This study used a quantitative approach and a cross-sectional design. The participants were 384 students (female/male: 226/168; mean age: 16 ± 1.98) in secondary high schools in Tehran in the academic year 2022–2023. The students were selected using convenience sampling. The data were collected online using the Revised Family Communication Pattern Scale (1994), Mobile-Based Social Network Addiction Questionnaire (2016), Child Behavior Checklist - Adolescent Version (2001), and the Affective Style Questionnaire (2010). The data were analyzed using structural equation modeling with SPSS-25 and AMOS-24 statistical software. Results. The study showed that emotional self-regulation plays a mediating role in the relationship between mobile-based social network addiction and internalized and externalized behavioral problems (P ≤ .05). The indirect effect of conversation orientation on internalized and externalized behavioral problems mediated by emotional self-regulation was not significant, but the indirect effect of conformity orientation on internalized and externalized behavioral problems with the mediation of emotional self-regulation was significant (P ≤ .05). Conclusion. Based on the findings, it is suggested that school officials and parents should develop emotional self-regulation and communication skills in students and parenting skills in their parents to prevent and reduce potential harm such as internet addiction and behavioral problems in students.
Personal Exposure to Social Media and Variations by Gender among Cuban Youth
Authors: Torralbas Oslé Jorge Enrique , Corcho Rosales Emely
Published: December 2023

Background. Personal exposure is a crucial aspect of digital socialization. It pertains to the amount of time spent on social networks, the number of active accounts, interactions on different platforms, the content published on social networks, the purpose for which the content is shared, the degree of personal exposure, and the changes in social life caused by the exposure. Gender plays an important role in predicting online behavior, but previous studies have yielded contradictory results. Objective. To characterize personal exposure to social media in young Cubans (networks used, hours of exposure, published content, how much of one's private life is exposed, alterations due to its use). To define the differences in personal exposure based on the gender variable. Design. A survey specifically created for this research was used. The sample was composed of 3345 young Cuban residents between 18 and 35 years old. Results. The young people spent a considerable amount of time per day on WhatsApp, Instagram*, and Facebook/Messenger*. Users shared content related to humor, music/art, and their personal lives. These interactions served as a source of entertainment, a means of communication and socialization, and a platform for expressing opinions on various topics. Personal content was shared frequently. The young people reported experiencing disturbances such as family demands, decreased attention span, difficulty sleeping, and decreased social interactions. There were gender differences in the level of personal exposure, with females reporting higher levels of exposure. Conclusion.There are high levels of personal exposure among Cuban youth. Different qualities are manifested according to gender. Females reflect the highest levels of personal exposure.
Threatening Quality of Will
Authors: Shoemaker David
Published: December 2023

Quality of Will (qw) theories of responsibility claim the target of someone’s blameworthiness for an action is their poor quality of will. There have been many “threats” to such a theory over the years, coming out of a literature interested in the metaphysical conditions of free will, threats having to do with moral luck, manipulation, and negligence. In this paper, I am more interested in surveying and thwarting two “new school” threats to qw theories, including taking responsibility for inadvertence, and holding reasonable but ostensibly wrongful beliefs. Both of these aim to ground blameworthiness independently of quality of will. I show that none of these new school threats to qw theories succeed.
Sampled Together: Assessing the Value of Simultaneous Collocated Measurements for Optimal Satellite Configurations
Authors: Powell C. E. , Ruf Christopher S. , Gleason Scott , Rafkin Scot C. R.
Published: December 2023

This work applies a quantitative metric in order to capture the relative representativeness of nonsimultaneous or noncollocated observations and quantify how these observations decorrelate in both space and time. This methodology allows for the effective determination of thresholding decisions for representative matchup conditions and is especially useful for informing future network designs and architectures. Future weather and climate satellite missions must consider a range of architectural trades to meet observing requirements. Frequently, fundamental decisions such as the number of observatories, the instruments manifested, and orbit parameters are determined based upon assumptions about the characteristic temporal and spatial scales of variability of the target observation. With the introduced methodology, representativity errors due to separations in space and time can be quantified without prior knowledge of instrument performance, and errors driven by constellation design can be estimated without model ingest or analysis.
Investigation of Hydrostatic Imbalance with Field Observations
Authors: Sun Jielun , Wulfmeyer Volker , Späth Florian , Vömel Holger , Brown William , Oncley Steven
Published: December 2023

The hydrostatic equilibrium addresses the approximate balance between the positive force of the vertical pressure gradient and the negative gravity force and has been widely assumed for atmospheric applications. The hydrostatic imbalance of the mean atmospheric state for the acceleration of vertical motions in the vertical momentum balance is investigated using tower, the global positioning system radiosonde, and Doppler lidar and radar observations throughout the diurnally varying atmospheric boundary layer (ABL) under clear-sky conditions. Because of the negligibly small mean vertical velocity, the acceleration of vertical motions is dominated by vertical variations of vertical turbulent velocity variances. The imbalance is found to be mainly due to the vertical turbulent transport of changing air density as a result of thermal expansion/contraction in response to air temperature changes following surface temperature changes. In contrast, any pressure change associated with air temperature changes is small, and the positive vertical pressure-gradient force is strongly influenced by its background value. The vertical variation of the turbulent velocity variance from its vertical increase in the lower convective boundary layer (CBL) to its vertical decrease in the upper CBL is observed to be associated with the sign change of the imbalance from positive to negative due to the vertical decrease of the positive vertical pressure-gradient force and the relative increase of the negative gravity force as a result of the decreasing upward transport of the low-density air. The imbalance is reduced significantly at night but does not steadily approach zero. Understanding the development of hydrostatic imbalance has important implications for understanding large-scale atmosphere, especially for cloud development.

Significance Statement

It is well known that the hydrostatic imbalance between the positive pressure-gradient force due to the vertical decrease of atmospheric pressure and the negative gravity forces in the vertical momentum balance equation has important impacts on the vertical acceleration of atmospheric vertical motions. Vertical motions for mass, momentum, and energy transfers contribute significantly to changing atmospheric dynamics and thermodynamics. This study investigates the often-assumed hydrostatic equilibrium and investigate how the hydrostatic imbalance is developed using field observations in the atmospheric boundary layer under clear-sky conditions. The results reveal that hydrostatic imbalance can develop from the large-eddy turbulent transfer of changing air density in response to the surface diabatic heating/cooling. The overwhelming turbulence in response to large-scale thermal forcing and mechanical work of the vast Earth surface contributes to the hydrostatic imbalance on large spatial and temporal scales in numerical weather forecast and climate models.
‘My Father's God’: John Fante, confession and Italianness
Authors: Crisante Francesca
Published: December 2023

This article examines John Fante's short story ‘My Father's God’ in order to show the importance of the Catholic religion for the integration of a typical family of Italian immigrants in the United States. Told by a first-person adult narrator who is recalling his father's resistance against the most rigid and orthodox forms of the Catholic church, ‘My Father's God’ is the representation of a model of masculine rebelliousness which, on the one hand, preserves all the characteristics of Italianness and, on the other, attempts to distance itself from it precisely in order to facilitate integration into the American social fabric. The narrative voice shows how the father (Nick) refuses to place religion (including confession) at the centre of his life. On closer inspection, this rebellious character is in perfect syntony with a gallery of male figures conceived by the author. From the point of view of its narrative structure, ‘My Father's God’ may be read on a metanarrative level as the story of another story (the confession written by Nick) which as it unfolds throws a significant light on John Fante's artistic awareness.
Satisfaction of the Police Personnel from their Working Conditions: A Case Study of Haryana
Authors: Dahiya Sewa Singh , Singh Samunder , Deswal Sunil
Published: December 2023

Working conditions in an organisation have a direct bearing on its performance. Better working conditions are a source of constant motivation for its employees, which further help in extracting their best towards realisation of organisational goals in terms of customer satisfaction. Police organisation is no exception and to generate people-friendly policing, amelioration in their working conditions is a necessity. The present study is an endeavour to make a detailed examination of the working conditions of the Haryana police personnel and their resultant satisfaction from them. To this end, a sample of 710 police personnel was drawn from various police establishments across the state for this study.
Transport users, and historie(s) of transport: “A view from below”
Authors: Mukhopadhyay Aparajita
Published: December 2023

This article proposes a methodological departure. It makes a case for foregrounding interactions between users and transport systems as a methodological departure to move beyond institutional perspectives in history of transport. This wider point is examined in this article through the illustrative example of how at an everyday level users negotiate/contest exclusionary practices and transport disadvantage. The article acknowledges the challenges of this methodological shift, especially the difficulties of recovering “everyday” experiences of transport users. It also recognises that users’ mediation and responses sit at the interstices of operational policies of transport infrastructure, individual/collective agency, and the workings of capital. Notwithstanding these caveats, the article suggests that innovative and explicit foregrounding of transport users has the potential to disaggregate the institutional perspective in writing histories of transport.
A Systemic Analysis of the Impact of the Pandemic on the Indian Tourism Economy
Authors: Munjal Poonam
Published: December 2023

The COVID-19 pandemic had a severe impact on the tourism industry across the world. Be it aviation or hospitality, transportation, tour operators or eateries, every activity related to tourism was adversely affected by the pandemic in an unprecedented manner. India saw the first severe impact during the first quarter of 2020–2021 when the tourism industry was severely affected, in terms of loss in tourism demand due to a significant fall in tourist arrivals. The industry saw gradual signs of recovery post-October 2020 but was hit again by the second wave during April–June 2021 and then by the third wave during November 2021–January 2022. Given the contribution that tourism makes to the entire economy in terms of income and employment generation, it is important to do a systemic estimation of the losses caused by the pandemic so that resilient policies are put in place to address the challenges at all levels and put the tourism sector back on the path it was traversing before the pandemic. This article presents the estimates of economic losses resulting from the changes experienced during the most critical period of the pandemic, that is, the first quarter of 2020–2021, which witnessed a complete lockdown, and the subsequent two quarters, wherein the sector started showing gradual recovery following various relaxations in economic activities and travel movements. The estimates are based on the methodology that draws from the framework laid out in the Tourism Satellite Account of India, which, in turn, is based on the methodological framework recommended by the United Nations World Tourism Organization.

JEL Codes: L830, Z320, F620
Formés œcuméniquement par la liturgie
Authors: Cochand Nicolas , Gazzola Isaia , Getcha Job
Published: December 2023

L'article (conférence donnée au congrès de la Societas Liturgica à Maynooth, août 2023) porte sur une expérience d'enseignement œcuménique de la liturgie dans le cadre de l'Institut supérieur d'études oecuméniques à Paris. Il est signé des trois enseignants (orthodoxe, catholique et protestant) en charge des cours. Il commence par un historique de cette expérience de près de vingt ans. Il donne ensuite des éléments de méthodologie, pour souligner enfin les apports qu'on peut en retirer. Il conclut qu'une approche oecuménique de la liturgie permet de porter un regard critique sur sa propre tradition, de mieux la comprendre en la situant dans une tradition plus large, mais en percevant aussi les spécificités et richesses des autres traditions.
God Perfectionism as a Mediator of Intrinsic Religiosity and Life Satisfaction: A Christian Sample of Young Adults
Authors: Duffield Cory , Mateer Elizabeth M. , Foster Madison , Jin Joel , Fung Winnie , Fung Joey
Published: December 2023

Intrinsic religiosity is a focus on religion for its own sake without consideration of its perceived external benefits. God perfectionism is an external source of perfectionism that is perceived to come from a higher power. This study investigates God perfectionism as a causal pathway between intrinsic religiosity and life satisfaction. Christian college students ( n = 125; male = 44%, female = 56%; Mage = 19.9 years, SD = 1.46, range = 15–56) were surveyed on perfectionism from God (standards and discrepancy), intrinsic religiosity, and satisfaction with life. Analyses indicated that intrinsic religiosity was associated with higher levels of life satisfaction ( b = .33, p = .0183). Our mediation analyses found significant indirect effects from intrinsic religiosity to life satisfaction through our mediator of perceived discrepancy from God ( b = .13, CI = .02 to .32), but the indirect effects via perceived standards from God were not significant. Results illustrate how intrinsic religiosity can affect life satisfaction based on one’s personal perception of God’s standards and discrepancies. Implications of these findings could lead to further research on what aspects of religiosity contribute to standards or discrepancy from God.
Is Psychopathy a Dynamic Risk Factor? An Empirical Investigation of Changes in Psychopathic Personality Traits Over the Course of Correctional Treatment
Authors: Moosburner Maeve , Etzler Sonja , Brunner Franziska , Briken Peer , Rettenberger Martin
Published: December 2023

This study examined whether there would be significant group-level and reliable individual changes in psychopathy measured via the Psychopathy Checklist–Revised (PCL–R) and the Interpersonal Measure of Psychopathy (IM–P) scores in a sample of 187 adult individuals with violent and sexual offense histories incarcerated and treated in a German social therapy facility (STF). Measurements were taken at entry into the STF and at (most) an 18-month follow-up. The results of dependent t-tests were significant, showing significant reductions in PCL–R and IM–P scores. Stronger significant reductions were observed for PCL–R Factor 1 scores and its corresponding facets compared with Factor 2 scores. Reliable individual changes measured via the Reliable Change Index (RCI) showed improvements in PCL–R and IM–P scores for some participants.
Influence of pistachio shell filler addition and interply hybridization on mechanical and thermal performances of polyester composites
Authors: Mohapatra Deepak Kumar , Deo Chitta Ranjan , Mishra Punyapriya , Dash Padmanav
Published: December 2023

Owing to the crucial qualities such as strength, stiffness and durability, as well as low-cost manufacturing benefits, the fibre-reinforced composite materials are becoming more popular in structural applications. The current work basically focused on the influence of Pistachio shell particles (PSP) on mechanical performances of kenaf(K)/glass(G)/polyester hybrid laminates. Usual hand layup technique is used to fabricate different stacking order laminates such as KKKK, KGGK, GKKG, KGKG, and GGGG with PSP filler concentration of 1 wt%, 3 wt% and 5 wt%. The experimental findings reflect a noticeable improvement in mechanical properties with gradual inclusion of PSP filler. The KGKG laminate with 5 wt% of PSP shows an optimum tensile strength of 127.35 MPa and highest micro-hardness value of 21.35 HV, whereas KGKG laminate with 3 wt% of PSP exhibits a maximum flexural of 112.42 MPa and impact strength of 75.59 KJ/m2. The numerical analysis is also been carried out to validate the experimental results using ANSYS 19.0 software. On comparing the data of numerical analysis with experimental values, the deviation of result is found to be within the limit of 5% to 10%. Furthermore, the result of Thermo Gravimetric Analysis (TGA) has shown a highest amount of residue of 31.22% at 700°C in case of GKKG laminate with 5% of PSP filler. Again, at 5 wt% of PSP filler, the GKKG laminate has shown a lower water intake capability of 3.5% in comparison to KGKG and KGGK laminates at saturation time of 14 days. The fractography study has been conducted to examine the different mode of failure of laminates during testing by the help of Scanning Electron Microscope (SEM).