bluuebunny/crossref_metadata_2025 huggingface dataset:
Upaya Meningkatkan Belajar IPA Tentang Gaya Magnet Melalui Penerapan Kegiatan Praktik KIT-IPA Pada Siswa Kelas V SDN Sumberbendo 02 Tahun Pelajaran 2019/2020
Authors: Suhartini Suhartini
Published: February 2023

Pembelajaran IPA di SDN Sumberbendo 02 belum optimal dilakukan. Hasil beajar siswa masih rendah dan belum mampu menggunakan media KIT IPA. Tujuan dari penelitian ini adalah meningkatkan hasil belajar siswa kelas V SDN Sumberbendo 02 dengan menggunakan KIT-IPA. Penelitian ini dilaksanakan di SDN Sumberbendo 02 Kecamatan Saradan, Kabupaten Madiun. Sumber data adalah siswa kelas V SDN Sumberbendo 02 sejumlah 17 orang siswa. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK). Hasil penelitian ini adalah adanya peningkatan hasil belajar berupa kemampuan praktikum dan hasil kognitif siswa kelas V SDN Sumberbendo 02 dengan menggunakan KIT-IPA. Hasil akhir menunjukkan sebanyak 100% siswa tuntas pada siklus ke II. Media KIT IPA juga dapat memberikan pengalaman yang nyata yang dapat menumbuhkan kegiatan berusaha sendiri dikalangan siswa. Manfaat dari media pembelajaran KIT IPA mampu mendukung kegiatan belajar mengajar,   menjadikan   media   pembelajaran   sangat   penting   untuk menunjang keberhasilan penyampaian pesan pembelajaran
Drivers and barriers to digitalisation: a cross-analysis of the views of designers and builders in the construction industry
Authors: Perera Srinath , Jin Xiaohua , Samaratunga Marini , Gunasekara Kasun
Published: February 2023

The construction industry around the world has identified the significance of digitalisation, and a wide range of research has explored the drivers and barriers of digitalisation within the construction industry. However, none has compared the views of designers and builders separately. Hence, this research critically reviewed drivers and barriers that affect the digitalisation of construction for designers and builders with an in-depth cross analysis. A detailed survey was conducted to capture drivers and barriers to digitalisation impacting the building sector in NSW, Australia. The survey captured the views of 542 respondents (347 designers and 195 builders), enabling the interpretation of results at a 95% level of confidence. Descriptive statistics were interpreted and cross analysis between designers and builders, and within different organisation sizes were conducted using the Mann-Whitney U test and Kruskal-Wallis H test. The survey findings were further verified through a series of primary stakeholder interviews (designers, builders, and software service providers). The findings of the survey, the cross-analysis, and the interviews were triangulated and collectively discussed to derive an in-depth understanding of drivers and barriers. ‘Greater level of accuracy and trustworthiness’ was rated the most important driver by both designers and builders, despite having significantly different response profiles. On the other hand, ‘high cost of software’ was rated the greatest barrier to digitalisation by both parties, whereas their response profiles were similar according to the cross analysis. In contrast to the designers, all builders had rated the top barriers in a similar way, irrespective of the size of the organisations. The results provide a greater understanding on the diverse views of designers and builders on drivers and barriers to the digitalisation of construction in NSW. This will direct government programmes and policy decisions to avoid considering both designers and builders as a monolithic block, when aiming at improving the state of digitalisation and performance of the construction industry.
Architektura informacji w witrynach internetowych Prawa i Sprawiedliwości oraz Platformy Obywatelskiej
Authors: Sajna-Kosobucka Paulina
Published: February 2023

Cel/Teza: Głównym celem badań jest ocena jakości architektury informacji w witrynach internetowych dwóch partii dominujących obecnie na polskiej scenie politycznej: Prawa i Sprawiedliwości (PiS) oraz Platformy Obywatelskiej (PO). Koncepcja/Metody badań: W badaniach wykorzystano triangulację kilku metod badawczych: ocenę jakościowo-heurystyczną architektury informacji na stronach WWW partii PiS i PO, ocenę ekspercką, analizę porównawczą witryn oraz obserwacje własne. Wyniki i wnioski: Choć obie witryny charakteryzują się standardową jakością, zostały zaprojektowane z uwzględnieniem zasad funkcjonalności. W obrębie badanych stron WWW widoczny jest brak niektórych istotnych składowych architektury informacji. Na podstawie przeprowadzonych analiz stwierdzono, że witryna partii PO jest jakościowo nieco lepsza od witryny partii PiS. Zastosowania praktyczne: Wyniki przeprowadzonych badań mogą być podstawą dla doskonalenia witryn poddanych analizie. Mogą mieć one również wpływ nie tylko na ocenę zaawansowania technologicznego partii PIS i PO, ale i także na ich wizerunek oraz odbiór społeczny, a w związku z tym też skuteczność w dotarciu do wyborców danej partii. Oryginalność/Wartość poznawcza: Przygotowane opracowanie ukazuje nową interpretację metody badawczej, którą jest ocena jakościowo-heurystyczna oparta na 74 kryteriach skupionych na potrzebach i kompetencjach użytkownika danego serwisu. Owo podejście wspomoże badania stron WWW w celu poprawy jakości doświadczeń użytkowników i bezproblemowej realizacji procesów informacyjnych.
FINANCIAL INDICATORS OF CORPORACIÓN TAPATÍA DE TELEVISIÓN FOR 2020-2021
Authors: Villalobos López  , José Antonio
Published: February 2023

The article is presented within the deductive method, under a gloss order and with a quantitative approach, with the objective of performing a financial analysis of channel 6 (later channel 5 and 35) of Guadalajara. Channel 6 was born in 1960 and in 1982 its concession was transferred to Corporación Tapatía de Televisión (CORTAP), a Grupo Medcom company. Until September 2020, it maintains a transmission contract with Televisa, which is declared economically predominant agent by the Instituto Federal de Telecomunicaciones (Federal Telecommunications Institute). Performing some tests of financial ratios for CORTAP, it is inferred that it is going through a critical moment since the end of 2020 and during the whole year of 2021, detecting a serious problem in its internal finances, since it presents a problem of acute indebtedness, caused by stock certificates that it issued in the Mexican Stock Exchange. We analyzed the financial information using the most recent methodologies of financial strategy, such as the Dupont system, the Ansoff matrix and the balanced scorecard, not finding how to solve the indebtedness problem. Recently (a few months ago) it became public knowledge that the concession was transferred to Telsusa Televisión México.
KEYWORDS: commercial television; economics of communication; financial resources; financial statements; television advertising.
COMPETITION AND COOPERATION IN THE MARKET GOODS WITH SATURATED DEMAND
Authors:   State University of Management, Moscow, Russia, Kuternin Mikhail I.
Published: February 2023

The article considers options for achieving market equilibrium in the oligopolistic market of goods with saturated demand. Cooperation and competition of oligopolistic producers are the most important factors influencing the characteristics of the market in question. The article developed a game theoretic model of such a market, and with its help various options for interaction between manufacturers were investigated. It has been established that the main parameters affecting the position of the manufacturer on the market are its production capabilities and the level of technologies used. It has been shown that non-cooperative equilibrium in such a market is possible only if strict antitrust measures are observed. Characteristics of such equilibrium were found. Various options for cooperative behavior of manufacturers have been investigated. With the help of the model proposed in the work, it is shown that on the studied market from a game theoretical point of view it is possible to appear equilibrium states of different nature: equilibrium by Stackelberg and Nash, as well as strong equilibrium. The article identifies the states under which these conditions arise in the market, and identifies the characteristics of these equilibrium states. The possibility of achieving market equilibrium based on threats has been studied separately. It has been established that the ratio of production capabilities of oligopolists who are market participants plays a decisive role in achieving a stable market state.
ECONOMIC SECURITY OF SMALL AND MEDIUM‑SIZED BUSINESSES
Authors:   Vyatka State University, Kirov, Russia, Elsukov Bogdan S.
Published: February 2023

This article provides a brief overview of small and medium-sized businesses. In addition, the scientific work of scientists studying economic security was analyzed. It also outlines ways to ensure the economic security of small and medium-sized businesses. The state of economic security and the logic of ensuring the economic security of entrepreneurship. In addition, proposals were made to ensure the economic security of small and medium-sized businesses.
ANALYSIS OF CHINA’S HEALTHCARE FINANCING SYSTEM
Authors:   Bauman Moscow State Technical University, Moscow, Russia, Sokolov Evgeny V , Kostyrin Evgeny V ,   Bauman Moscow State Technical University, Moscow, Russia, He Pingping ,   Bauman Moscow State Technical University, Moscow, Russia
Published: February 2023

The article analyzes the development of the health insurance system of the Chinese population since 1950. The paper shows that China has been using medical savings accounts (MSA) as a key element of the urban healthcare financing system since 1994. In addition to the specifics of the introduction of MSA in China, it reveals the benefits of MSA for working citizens, business and the health of Chinese citizens.
ALTERNATIVE FINANCING AND MODERNIZATION OF FINANCIAL SERVICES TO PROMOTE EXPORT DIVERSIFICATION IN AFRICA
Authors:   Institute of Africa of the Russian Academy of Sciences, Moscow, Russia, Saenko Aleksey N.
Published: February 2023

The article explores the relationship between financial services, private sector development and export diversification, with a special focus on financial factors that affect export diversification at the firm level. In many African countries, the existing financial structure may not provide more flexibility and resources to support the factors determining exports, which leads to a decrease in export potential and diversification of export baskets. The financial system in Africa mainly revolves around the banking sector, which accounts for more than 90 percent of financial sector assets. The author argues that the current financing structure of the banking sector may not be suitable for the growth of small firms and export indicators, which requires special financing mechanisms, such as venture capital, as well as financial technologies that can improve traditional credit channels and offer other promising channels to eliminate the financing deficit of micro, small and medium-sized enterprises.
FORMATION OF A SOLVEN CUSTOMER SEGMENT IN MORTGAGE LENDING USING MACHINE LEARNING AND ARTIFICIAL INTELLIGENCE
Authors:   Bryansk State University named after academician I. G. Petrovsky, Bryansk, Russia, Zverev Аleksey V. , Mishina Marina Yu. ,   Bryansk State University named after academician I. G. Petrovsky, Bryansk, Russia, Korchebny Vladimir V. ,   Bryansk State University named after academician I. G. Petrovsky, Bryansk, Russia
Published: February 2023

The article discusses the system of mortgage lending in Russia, its economic and social significance, elements of infrastructure and the mechanism of functioning. It analyzes the possibility of various types of operational, credit, market risks in the formation of a high-quality loan portfolio and ways to minimize them. Methods are being developed to ensure a solvent segment of customers in mortgage lending, based on the use of artificial intelligence and machine learning.
PREREQUISITES FOR CHANGING THE INFORMATION AND ANALYTICAL SUPPORT FOR THE ORGANIZATION AND HOLDING OF THE ALL-RUSSIAN YOUTH SCIENTIFIC AND ENGINEERING EXHIBITION “POLYTECHNIC”
Authors:   Bauman Moscow State Technical University, Moscow, Russia, Shevchun V. N. , Strokov V. V. ,   Bauman Moscow State Technical University, Moscow, Russia
Published: February 2023

The article discusses the issues of preparation, organization and holding of the student scientific and engineering exhibition “Polytechnic”; combining theoretical research and practical experience.
ON THE WAY TO THE FUTURE Socio-economic development in the context of history in the book: Filosofova T. G., Syrtsov D. N., Syrtsova O. N. (2022) Filosofovs: travels from Kostroma to Pskov via Moscow and St. Petersburg or the thousandyear history of a hereditary noble family in persons
Authors:   Diplomatic Academy of the Ministry of Foreign Affairs of the Russian Federation, Moscow, Russia, Kutovoy Vladimir M.
Published: February 2023

The article gives a positive assessment of the book under review, notes the importance of interdisciplinary studies of socio-economic processes conducted by its authors in a historical context, taking into account the contributions of representatives of the Russian hereditary noble family of the Filosofovs. The materials presented in the book draw attention to the objects of cultural heritage, to the problem of their preservation and prospects for the promotion of regional museums in the market of tourist services. The special advantage of the book is that it raises the issue of the formation of people's spiritual and moral guidelines and humanistic values, which is relevant for our time.
Екологічна освіта дітей та учнівської молоді у практиці сьогодення
Authors: Драгомерецька Ольга
Published: February 2023

У статті розкрито основні теоре- тичні засади й прикладні підходи до організації та здійснення освітньо-виховної, розвивальної й соціалі- зуючої роботи педагогічних колективів закладів за- гальної середньої і позашкільної освіти з екологічної освіти дітей та учнівської молоді, що спрямовується на забезпечення потреб особистості у творчій само- реалізації, поглибленні й розширенні базового рівня екологічної освіти. Схарактеризовано діяльність пе- дагогічного колективу Вінницької обласної станції юних натуралістів щодо координації еколого-натура- лістичної, природоохоронної, експериментально-до- слідницької роботи з дітьми та учнівською молоддю в закладах освіти області. Розкрито напрями вдо- сконалення екологічної освіти учнів різного віку в за- кладах освіти завдяки організації і діяльності майже пів сотні учнівських лісництв, екологічних агітбригад та екотеатрів, трудових аграрних об’єднань стар- шокласників, учнівських виробничих бригад і трудових загонів, проведення різноманітних екологічних експе- дицій та роботи на екологічних стежинах тощо.
Gambaran Kepatuhan Hand Hygiene Perawat di Instalasi Dialisis RSUD Dr. Soetomo Surabaya Tahun 2022
Authors: Fithriasari Mariatul , Isfandiari Muhammad Atoillah , Lestari Tri Budi
Published: February 2023

Healthcare-Associated Infection is one of the health problems in the world. In Indonesia, the incidence of Healthcare-Associated infections is relatively high. Patients with chronic kidney disease undergoing hemodialysis are at increased risk for Infection. The main chain of infection transmission is from the hands of health workers. Hand hygiene is essential in preventing Infection. However, the hand hygiene compliance of health workers is still low. This study aimed to describe the nurse's hand hygiene compliance, identify the factors that influence it and determine solutions to improve it. This study was descriptive-observational. The population of this study was all dialysis nurses in the Dialysis Unit of Dr. Soetomo General Hospital Surabaya. The sample size based on WHO requirements was 200 opportunities for hand hygiene. Identify the root cause using a fishbone diagram—determine alternative solutions to problems using Capability, Accessibility, Readiness, and Leverage methods. Based on the observations, nurses' compliance with hand hygiene was 28.5%. The lowest nurse compliance rate is at the indication before and after touching the patient. The factors that most influence the hand hygiene of dialysis nurses are the lack of knowledge and awareness of the importance of hand hygiene and the performance of the IPCLN team, which is not optimal. Hand hygiene socialization more creatively and sustainably, as well as improving the performance of the Infection Prevention and Control Team at the Dialysis unit, is expected to be able to increase hand hygiene compliance optimally.

 Keywords: Hand hygiene, Compliance, Nurses, Infection
Medical Conditions Associated with Mining and Fishing Activities in Migori County: A Comparative Study
Authors: Odhiambo Enock Otieno , Mitaki Elizabeth , Gachohi John
Published: February 2023

The purpose of this research study was to do a comparative study on medical conditions that are associated with fishing and mining occupations in Migori County, Kenya. The study was shaped by three main objectives; to determine medical conditions associated with miners in Migori County, to identify medical conditions experienced by fishermen in Migori County and to establish the differences in medical conditions among miners and fishermen in Migori County. The study employed both quantitative and qualitative designs. It was carried out in the Nyatike Sub-County of Migori County. The target population of the study included miners from 25 sampled mining sites and fishermen from Mugabo BMU (Beach Management Unit) in the Nyatike sub-county. A sample of 400 participants participated in this study where Mugabo BMU was allocated 200 participants and other selected 25 mining sites allocated 8 each. The study used random sampling to generate its sample size. The data collection exercise used a visualisation semi-structured interview where a checklist was used together with probing, observation, and a questionnaire. The data was later ranked and scored through simple ranking, pairwise ranking, proportional pilling and matrix scoring. The data was presented by mapping, paragraphing and use of tables and other quantitative methods. The study established that infectious diseases are still the main cause of ill health among people practising mining and fishing occupations, besides rampant injuries. Clinical syndromes like stomach aches, coughs, and allied diseases, physical injuries were very common in the two occupations. The study, therefore, recommends the provision and use of Personal Protective Equipment (PPE) to reduce the number of injuries as well as support various amenity services, security, and proper regulations
Experiences of an Insider in Qualitative Research: My Doctoral Research Journey in a Public University, Kenya
Authors: Muasya Juliet Njeri
Published: February 2023

Qualitative researchers position themselves more as ‘insiders’ than ‘outsiders’ due to the nature of the research paradigm. In this paper, I will present and discuss my role and experiences as an insider researcher during my doctorate research journey. I begin by exploring the debate surrounding the role of an insider in qualitative research, in addition to highlighting key arguments within the literature, while reflecting on my personal experiences as a PhD candidate. In particular personal experiences that made the researcher play the role of an ‘insider’ more as compared to an ‘outsider’ researcher will be discussed. The first part of this paper will cover the conceptualisation of the terms ‘insider’ and ‘outsider’. This will be followed by a discussion and presentation of key discourses based on the role of an ‘insider’ in qualitative research. Being an insider researcher, I was able to access research institutions to collect data without having to organise ‘settling in’, which made it possible to collect data every day of the week at any time of the day, thus providing continuity in the data collection process. More so, I was able to control the research process by using stories, voice, and transcripts. Since it was a sensitive study, as an insider researcher, I did consider ethical concerns and the importance of counselling the participants. Challenges based on the risk of insider struggling between their role as a group member and a researcher are presented. In addition, the delicate balancing that the researcher engaged in while deciding how much of the insider information is to be shared with the participants is discussed
IDENTIFIKASI RISIKO KESELAMATAN DAN KESEHATAN KERJA PADA PENGOPERASIAN INCINERATOR
Authors: Tarigan Sylva Flora Ninta , Abudi Ramly , Malahika Jelita Agustina
Published: February 2023

Keselamatan dan kesehatan kerja (K3) adalah usaha untuk sedapat mungkin menjamin keselamatan dan kesehatan pada pekerja sehingga pekerja dapat merasa aman dan nyaman bekerja ditempatnya. Tujuan penelitian untuk mengidentifikasi risiko keselamatan dan kesehatan kerja pada pengoperasian incinerator di Rumah Sakit Umum Daerah (RSUD) Prof. Dr. H. Aloei Saboe Kota Gorontalo. Desain penelitian ini merupakan desain deskriptif dengan pendekatan mixed method. Informan penelitian terdiri dari 1 informan kunci, 1 informan utama dan 1 informan pendukung. Pengumpulan data melalui observasi, wawancara terstruktur dan dokumentasi. Hasil penelitian bahwa pada setiap pekerjaan di area pengoperasian incinerator berpotensi bahaya mekanis, listrik, biologi, kimia, dan ergonomi. Hasil penilaian risiko didapatkan 1 risiko tinggi sehingga memerlukan tindakan lanjutan dan 60 risiko rendah sehingga risiko dapat diterima. Faktor penyebab risiko tertinggi didapatkan 31 akar penyebab permasalahan seperti pekerja tidak mengikuti SOP dan pekerja kurang pengetahuan. Rekomendasi pengendalian terhadap faktor penyebab risiko tertinggi dan didapatkan 10 rekomendasi pengendalian administratif. Simpulan bahwa terdapat 1 risiko tertinggi yaitu cedera ringan/berat akibat tidak menggunakan APD lengkap.
KELAYAKAN KOTA JAYAPURA SEBAGAI KOTA LAYAK AKTIVITAS FISIK
Authors: Kurdi Kurdi , Ibrahim Ibrahim , Kardi Ipa Sari , Nopiyanto Yahya Eko
Published: February 2023

Upaya mewujudkan visi misi Desain Besar Olahraga Nasional (DBON) yang berisikan arah kebijakan dan pembinaan olahraga salah satunya yaitu olahraga rekreasi yang ditujukan kepada masyarakat umum untuk menjaga kebugaran. Berdasarkan hal tersebut diharapkan Kota Jayapura dapat melaksanakan program DBON secara terintegrasi dan kolaboratif. Penelitian ini bertujuan untuk melakukan survei kelayakan Kota Jayapura sebagai Kota yang layak untuk aktivitas fisik. Berdasarkan hal tersebut untuk mengetahui apakah memenuhi syarat kelayakan, maka perlu dilakukan survei kelayakan berdasarkan parameter yang meliputi keamanan, kenyamanan, dan kelayakan dapat dinikmati oleh masyarakat. Penelitian ini merupakan penelitian survei dengan menggunakan pendekatan kualitatif. Instrumen penelitian ini meliputi: lembar observasi, dan lembar dokumentasi. Sumber data penelitian adalah dokumentasi peneliti saat melakukan survei di lokasi bekas pelaksanaan Pekan Olahraga Nasional (PON) XX Papua dan area terbuka publik di dalam Kota Jayapura. Teknik analisis data kualitatif ini menggunakan model analisis tiga tahap, yaitu: reduksi data, penyajian data, dan penarikan kesimpulan/verifikasi. Hasil penelitian ditemukan bahwa venue PON XX Papua di Kota Jayapura memenuhi syarat keamanan, kenyamanan, dan kelayakan beraktivitas fisik. Berdasarkan hasil penelitian yang diperoleh dapat disimpulkan bahwa Kota Jayapura memenuhi syarat sebagai kota yang layak untuk beraktivitas fisik dengan venue berupa sarana prasarana peninggalan PON Papua XX.
LATIHAN PLIOMETRIK DAN KECEPATAN TERHADAP KEMAMPUAN TENDANGAN SABIT
Authors: Kamarudin Kamarudin , Zulrafli Zulrafli , Irma Ade
Published: February 2023

Tendangan sabit merupakan salah satu jenis tendangan dalam Pencak silat yang sering dilatihkan oleh seorang pelatih. Tujuan penelitian ini untuk mengetahui pengaruh metode latihan Pliometrik dan latihan kecepatan terhadap kemampuan Tendangan sabit pada atlet Pencak silat Unit Kegiatan Mahasiswa Universitas Islam Riau. Metode dalam penelitian ini menggunakan metode eksperimen semu (quasi eksperimen). Populasi berjumlah 26 atlet, penarikan sampel dalam penelitian ini secara total sampling semua populasi dijadikan sampel sebanyak 26 orang atlet putra. Pengukuran kemampuan Tendangan sabit menggunakan tes kemampuan Tendangan sabit Pencak silat. Data yang sudah diperoleh dianalisis dengan menggunakan uji-t. Berdasarkan hasil analisis data yang didapatkan menunjukkan bahwa metode latihan Pliometrik memberikan pengaruh yang signifikan terhadap kemampuan tendangan sabit pada atlet Pencak silat, latihan kecepatan memberi pengaruh yang signifikan terhadap kemampuan Tendangan sabit pada atlet Pencak silat, apabila dibedakan antara metode latihan Pliometrik dengan latihan kecepatan yang dilakukan secara bersama-sama, maka terdapat pengaruh yang signifikan terhadap kemampuan Tendangan sabit atlet Pencak silat Unit Kegiatan Mahasiswa Universitas Islam Riau. Untuk meningkatkan kemampuan Tendangan sabit, metode latihan pliometrik lebih baik dibadingkan metode latihan kecepatan.
Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment
Authors: Ouyang Yi , Chen Yan , Xu Ting , Sun Yihao , Zhao Sheng , Chen Chunmei , Tan Yixin , He Liang , Liu Hui
Published: February 2023

Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA) nanocomposites for killing tumor cells.
Methods: MPDA nanoparticles were synthesized and functionalized with camptothecin (CPT) payload and manganese dioxide (MnO2) coating to construct MPDA-CPT-MnO2 nanocomposites.
Results: When uptaken by tumor cells, the nanocomposites can degrade to produce O2, release CPT, and generate manganese (Mn2+) under the stimulation of hydrogen peroxide (H2O2) and acid. The released CPT and Mn2+ can act as chemotherapeutic drug and Fenton-like agent, respectively. Abundant reactive oxygen species (ROS) are generated in 4T1 tumor cells through an Mn2+-mediated Fenton-like reaction. After that, the generated Mn4+ can react with glutathione (GSH) through redox reaction to produce Mn2+ and deplete GSH, disrupting the reducing capacity and benefiting the production of ROS in tumor cells. Under laser irradiation, the nanocomposites can generate hyperthermia to promote the production of ROS.
Conclusions: The developed MPDA-CPT-MnO2 nanocomposites can kill tumor cells through collaborative chemo/photothermal/chemodynamic therapy (CDT).
Role of tumor necrosis factor receptor-associated factor 5 in B- and T-lymphocytes
Authors: Hikosaka Kuniishi Mari , Ishii Naoto , So Takanori
Published: February 2023

Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of intracellular signaling adaptors that associate with the cytoplasmic tails of a diverse range of lymphocyte receptors, including members of the TNFR superfamily, the Toll-like receptor (TLR)/interleukin-1 (IL-1) receptor superfamily, and the IL-6 receptor family that are major targets for therapeutic intervention for inflammatory diseases. TRAF5 is one of the seven family members of the TRAF family and is highly expressed by B- and T-lymphocytes. As compared to other family members, the biological and pathophysiological functions of TRAF5 have remained ambiguous since its discovery. TRAF5 promotes lymphocyte signaling for the TNFR family molecules such as glucocorticoid-induced TNFR family-related protein (GITR), CD27, and CD40. In contrast, TRAF5 limits the activity of the common signaling receptor subunit glycoprotein 130 kDa (gp130) in CD4+ T cells that requires signaling by IL-6 and IL-27. TRAF5 also restrains TLR signaling in B cells. Thus, TRAF5 regulates lymphocyte signaling in both positive and negative ways. This review will summarize the findings of recent studies of TRAF5 in terms of how TRAF5 regulates signaling in lymphocytes and other cell types and how TRAF5 expression contributes to inflammatory and autoimmune diseases in mice and humans.
Oxidative stress, inflammation, dysfunctional redox homeostasis and autophagy cause age-associated diseases
Authors: Sobhon Prasert , Savedvanich Gavin , Weerakiet Sawaek
Published: February 2023

Aging and age-associated diseases (AADs) are growing risk factors in societies worldwide. During aging, there is an accumulation of excessive oxygen free radicals [reactive oxygen species (ROS)] and nitrogen free radicals [reactive nitrogen species (RNS)] due to dysfunctional mitochondria, dysregulated catalytic activities of cytochrome P450 (CYP), nicotinamide adenine dinucleotide (NAD) phosphate [NADP(H)] oxidase (NOX), cyclooxygenases, and nitric oxide synthases (NOS) over the threshold of physiological levels, creating oxidative stress (OS). Excessive ROS and RNS oxidize, break, denature, and sometimes cause aggregations of key cellular components including DNA, proteins, and lipids. Normally, these denatured molecules and their aggregates are eliminated by autophagy (AP) and ubiquitin-proteosome system (UPS). However, these two proteostatic mechanisms are impaired as age progresses. As a result, these abnormal molecules turn into damage-associated molecular patterns (DAMPs), recognized as non-self by immune cells, leading to systemic chronic inflammation (SCI), which together with OS are the major causes of aging and AADs. Therefore, instead of trying to prevent and cure AADs individually, the logical approach should be the restoration of redox homeostasis by the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway which can prevent the damaging effect of OS and the upregulation of AP and UPS to eliminate DAMPs, and together they attenuate SCI to lessen the effect of inflammation. The central regulators, adenosine monophosphate-activated protein kinase (AMPK), sirtuin 1 (SIRT1), and Sestrins, synergistically control the restoration of the redox homeostasis by activating Nrf2, the upregulation of AP-UPS, and the inhibition of SCI. The activation of these central regulators can be achieved by exercise, caloric restriction (CR), and intakes of certain CR mimetic natural compounds. Consequently, the activations of these regulators may lead to the prevention and/or attenuation of the AADs.
Enhancement of reactive oxygen species production in triple negative breast cancer cells treated with electric pulses and resveratrol
Authors: Giri Pragatheiswar , Camarillo Ignacio G. , Sundararajan Raji
Published: February 2023

Aim: Triple negative breast cancer (TNBC) is difficult to treat since it lacks all the three most commonly targeted hormone receptors. Patients afflicted with TNBC are treated with platinum core chemotherapeutics, such as cisplatin. Despite the initial effective anticancer effects of cisplatin, TNBC attenuates its effect and develops resistance eventually, which results in tumor reoccurrence. Hence, there is a critical demand for effective, alternative, and natural ways to treat TNBC. Towards this, a promising technique for inhibiting TNBC cell proliferation involves promoting the production of reactive oxygen species (ROS), which triggers pro-apoptotic caspases 9 and 3. Resveratrol (RESV), an active bio compound found in naturally available fruits, such as grapes, is utilized in this research for that. In addition, electrochemotherapy (ECT), which involves the application of electrical pulses (EP), was utilized to enhance the uptake of RESV.
Methods: MDA-MB-231, human TNBC cells were treated with/out RESV, and eight 600–1,000 V/cm, 100 μs pulses at 1 Hz. The cells were characterized by using various assays, including viability assay, and ROS assay.
Results: A TNBC cell viability of as low as 20% was obtained at 24 h (it was 13% at 60 h), demonstrating the potential of this novel treatment. ROS production was the highest in the combination of EP at 1,000 V/cm along with RESV at 100 μmol/L.
Conclusions: Results indicate that RESV has the potential as an anti-TNBC agent and that EP + RESV can significantly enhance the cell death to reduce MDA-MB-231 cell viability by increasing ROS production and triggering apoptosis.
A Systematic Literature Review: Entrepreneurship Learning in Higher Education
Authors: Kesuma Tubagus Ali Rachman Puja , Rosidin Undang , Yulianti Dwi , Pargito Pargito , Ridwan Ridwan , Ciciria Deri , Wardani Wardani , Purwasih Atik , Mustofa Imam , Zainaro M. Arifki , Isnainy Usastiawaty C. A. S , Tusianah Rias , Irawan Edy , Mulyanah Ade , Zalmansyah Achril , Sujarwo Sujarwo
Published: February 2023

This research aims to look at entrepreneurship learning in higher education. The author concludes that: 1) The parties involved and contributing to the success of entrepreneurship learning are students, educators, entrepreneur practitioners, and the community. 2) The involvement of the four parties is conceptualized in a combination of learning which includes field survey activities, literature studies, the involvement of practitioners, portfolio preparation, and field practice. The study contributed to the development of entrepreneurship education in higher education, to produce a proud outcome.
Sobre la interpretación conforme al Derecho de la UE con efectos "in malam partem"
Authors: Bernardi Alessandro
Published: February 2023

En los últimos años, el debate sobre los límites de la adaptación hermenéutica de las leyes penales nacionales para cumplir con el derecho de la UE se ha vuelto cada vez más acalorado. En este trabajo, trataré de trazar la historia de la interpretación conforme in malam partem, tal como ha evolucionado en la jurisprudencia italiana, en las posiciones del Tribunal de Justicia y en las disputas doctrinales. Trataré asimismo de argumentar sobre los posibles —y, como veremos, discutibles— espacios reservados para los efectos desfavorables derivados de este tipo de interpretación.
Digital Literature Literacy (DLL) and Literature Digital Reading (LDR) in European Schools
Authors: Canals-Botines Mireia , Raluy Alonso Angel
Published: February 2023

DILECTINGS (Digital Literature Educational Competences for Teachers: Intercultural Inclusive Good Practices) is a European Key Action 2 Project that explores digital literature teaching. Digital literature—literature intended as authentic materials with cultural value—is an engaging and interactive narrative form delivered via digital media, that encompasses the language of books, films, web pages, radio, among others. This paper aims to present a preliminary questionnaire to explore the needs of primary and secondary teachers in terms of digital literature literacy and literature digital reading. This article will show the questionnaire design process to carry out a proper needs analysis.
Redes sociales en la mejora del aprendizaje de las áreas STEM en educación secundaria
Authors: Álvarez-Herrero Juan-Francisco
Published: February 2023

The present demands the transformation of education with the introduction of new strategies and resources that guarantee a quality education. The use of social networks can report improvements in student learning. This research tries to find out the perceptions of STEM teachers regarding the use of social networks to improve learning. Carrying out effective training in the use of these networks in STEM education allows both the improvement of teachers' perceptions of these networks, and an increase in their use in their daily practices.
Facebook como herramienta educativa en grupos horizontales de universitarios: emociones y comunicación
Authors: Suárez Ramírez José Carlos
Published: February 2023

The objective of this research is to correlate communications and the emotional dimension, and to know the expressive variety used by university students in their horizontal groups on Facebook.A descriptive and longitudinal methodology is applied, collecting qualitative and quantitative information through observation.The study population is composed of 3,592 students during the scholar year 2015/16 and 2,756 in 2022.The results obtained indicate that the emotional dimension is present in student groups, and its usefulness for educational purposes, in Facebook, hence the desirability of using this social network in university education.
Internal Revenue Allotment: The Case of Barangay Calamba, Cebu City
Authors: U. Gulane Ian Rovii , C. Viray Marecon
Published: February 2023

This study focused on exploring the knowledge level of awareness and implementation of the Internal Revenue Allotment in Barangay Calamba, Cebu City. It sought to determine the answer 1. What is the demographic profile of the respondents, 2. What is the level of awareness of the respondents towards internal revenue allotment? 3. What are the strategies used by the Barangay Captain in collecting internal revenue allotment and its level of implementation? 4. What is the perception of the respondents on the contribution of the collected Real Property Tax to the operation of Barangay Calamba? The research design used was descriptive, that is by employing percentage distribution and frequency counts in presenting and analyzing the data obtained from a sample of fifty-eight (58) respondents. A validated researcher-made questionnaire was used to collect the primary data. The findings on this study revealed there was a barangay development plan; however, budget allocation is the problem observed, and these plans were not fully implemented.
ANALYSIS OF HAZARDOUS AND HARMFUL PRODUCTION FACTORS AT THE TREATMENT FACILITIES OF OOO LUKOIL-NIZHEGORODNEFTEORGSINTEZ
Authors: Логинов Сергей Николаевич , Пачурин Герман Васильевич
Published: February 2023

В работе проведен анализ условий труда, машин и механизмов, с точки зрения возможности появления опасных факторов, выделения вредных производственных веществ. Показано, что условия труда в ОС ООО «Лукойл-Нижегороднефтеоргсинтез» соответствуют нормативным и отрицательного воздействия на здоровье и работоспособность рабочего не оказывают.

The work analyzes working conditions, machines and mechanisms, from the point of view of the possibility of the appearance of hazardous factors, the release of harmful production substances. It is shown, that the working conditions in the OS of OOO Lukoil-Nizhegorodnefteorgsintez correspond to the normative ones and do not have a negative impact on the health and working capacity of the worker.
ЭКОНОМИЧЕСКАЯ БЕЗОПАСНОСТЬ ГОСУДАРСТВА В УСЛОВИЯХ ЦИФРОВОЙ ТРАНСФОРМАЦИИ ЭКОНОМИКИ
Authors: Ермолаев Константин Николаевич , Ребров Сергей Денисович
Published: February 2023

В статье затрагиваются проблемы безопасности государства в сфере экономики в период цифровой трансформации. Раскрывается сущность понятий цифровизации и экономическая безопасность. Анализируется вопрос возникновения возможных рисков и проблем в переходный период.

The article touches upon the problems of state security in the economic sphere during the period of digital transformation. The essence of the concepts of digitalization and economic security is revealed. The issue of possible risks and problems in the transition period is analyzed.
REUSE OF WASTE MATERIALS AS A RESULT OF THE DISMANTLING OF BUILDINGS AND STRUCTURES
Authors: Зайдулин Вячеслав Олегович , Пачурин Герман Васильевич
Published: February 2023

Для реализации использования отработанных материалов в результате демонтажа зданий и сооружений создано предприятие по благоустройству. За десять лет планируется очистить 24 миллиона квадратных метров территории, демонтировать 500 зданий и убрать два миллиона тонн отходов и 615 тысяч тонн металлолома. На месте демонтированных зданий планируется постройка новых жилых домов и объектов инфраструктуры.

To implement the use of waste materials as a result of the dismantling of buildings and structures, a landscaping enterprise was created. In ten years, it is planned to clear 24 million square meters of territory, dismantle 500 buildings and remove two million tons of waste and 615 thousand tons of scrap metal. In place of the dismantled buildings, it is planned to build new residential buildings and infrastructure facilities.
THE IMPACT OF DESIGN DECISIONS ON TERRITORIAL PLANNING OF TERRITORIAL DEVELOPMENT ON SOCIO-ECONOMIC EFFECTS
Authors: Волков Андрей Владимирович
Published: February 2023

Рассмотрена важность долгосрочного планирования территории с оценкой экономических и социальных рисков и эффектов необходимо для развития субъектов Российской Федерации на всех уровнях вплоть до муниципалитетов.

The importance of long-term planning of the territory with an assessment of economic and social risks and effects necessary for the development of the subjects of the Russian Federation at all levels up to municipalities is considered.
GLOBALIZATION OF THE MONETARY AND FINANCIAL SPHERE, ITS CONSEQUENCES
Authors: Алейникова Алина Борисовна , Прокопенко Анастасия Александровна , Перепелкин Вячеслав Александрович
Published: February 2023

Развитие финансовой глобализации имеет свои отличительные черты. В результате экономических перемен, капитал обретает способность мобильности, то есть, перемещения в рамках всего мира с целью поиска более выгодных возможностей и экономических предложений. При этом, главная проблема заключается в том, что последствия процесса финансовой глобализации для мировой экономики в XX и XXI века и отдельных национальных финансовых рынков могут иметь как позитивное, так и негативное значение.

The development of financial globalization has its own distinctive features. As a result of economic changes, capital acquires the ability to move, that is, move around the world in order to find more profitable opportunities and economic offers. At the same time, the main problem is that the consequences of the process of financial globalization for the world economy in the XX and XXI centuries and individual national financial markets can have both positive and negative significance.
DECENTRALIZED AUTONOMOUS ORGANIZATIONS IN A PERIOD OF GEOPOLITICAL INSTABILITY
Authors: Семенов Алексей Александрович , Тесленко Ирина Борисовна
Published: February 2023

В статье описаны децентрализованные автономные организации, как субъект экономических отношений, рассмотрены варианты их использования в период санкционного давления, раскрыты недостатки этой технологии на текущем этапе.

The article describes decentralized autonomous organizations as a subject of economic relations, considers options for their use during the period of sanctions pressure, reveals the shortcomings of this technology at the current stage.
NOMINATION METHODS OF IT PROFESSIONALS
Authors: Черепанова Елена Михайловна , Матвеева Екатерина Валерьевна
Published: February 2023

В статье рассматриваются наиболее продуктивные способы номинации профессионализмов сферы ИТ, обозначающих составные части компьютера.

The article is devoted to the study of the most productive methods of nomination for IT professionalisms, denoting computer components.
SOME PARTICULAR CONSEQUENCES OF THE THEORY OF GRAVITY WITH SCALE-TURN-REFLECTION TRANSFORMATIONS
Authors: Тележко Георгий Михайлович
Published: February 2023

Предложено описание гравитации с потенциалом поля в виде тензора H , где HH = H δ , δ - единичный тензор. Теория удовлетворяет принципу относительности ускоренного движения и в слабом поле соответствует теории Ньютона. Отношение квадрата скорости света к гравитационной постоянной в начале любой системы отсчёта имеет смысл интеграла по объёму Вселенной от отношения плотности массы к расстоянию до начала отсчёта.

A description of gravity with a field potential in the form of a tensor H is proposed, where HH = H δ , δ is a unit tensor. The theory satisfies the principle of relativity of accelerated motions and in a weak field corresponds to Newton's theory. The ratio of the square of the speed of light to the gravitational constant at the beginning of any reference frame has the sense of the volume integral over the Universe of the ratio of mass density to distance to the beginning of the reference frame.
ESTIMATION OF THE AVERAGE DENSITY OF THE LOCAL CLUSTER OF MATTER IN THE THEORY OF GRAVITY WITH SCALE-ROTATION-REFLECTION TRANSFORMATIONS
Authors: Тележко Георгий Михайлович
Published: February 2023

В теории гравитации с потенциалом H , где HH = H δ , δ -единичный тензор, гравитационное взаимодействие приводит к кластеризации материи и антиматерии во Вселенной. Отношение квадрата скорости света к гравитационной постоянной, равное интегралу от отношения плотности массы к расстоянию до начала отсчёта, позволяет оценить среднюю плотность материи в местном кластере для различных предположений о его размерах.

In the theory of gravity with a potential H , where HH = H δ , δ is a unit tensor, the gravitational interaction leads to clustering of matter and antimatter in the Universe. The ratio of the square of the speed of light to the gravitational constant, being equal to the integral of the ratio of mass density to distance before reference, allows us to estimate the average density of matter in the local cluster for various assumptions about its size.
ASSESSMENT OF THE EFFECTIVENESS OF PUBLIC ADMINISTRATION IN THE FIELD OF GENERAL EDUCATION AT THE MUNICIPAL LEVEL
Authors: Ткачёва Александра Васильевна , Тасуева Иман Лемаевна
Published: February 2023

Работа посвящена одной из актуальных тем на сегодняшний день - оценке эффективности государственного управления в системе образования на муниципальном уровне. В этом исследовании были рассмотрены разные аспекты данных оценок в том числе построение формул касающихся направлений муниципальной политики в образовании.

The scientific work is devoted to one of the most relevant topics today - it is the assessment of the effectiveness of public administration in the education system at the municipal level. In our study, we tried to consider the ways of various aspects of these assessments, including through the construction of formulas concerning the directions of municipal policy in education.
DEVELOPMENT OF PROFESSIONAL COMPETENCIES OF EMPLOYEES OF SOCIAL SERVICE ORGANIZATIONS
Authors: Артемова Юлия Сергеевна
Published: February 2023

В статье представлены аргументы, обосновывающие необходимость формирования профессиональных компетенций работников организаций социального обслуживания населения. Представлена авторская трактовка понятия «профессиональная компетенция». Раскрыто содержание ключевых профессиональных компетенций работников организаций социального обслуживания граждан.

In the article presents arguments justifying the need for the formation of professional competencies of employees of social service organizations. In the article presented the author's interpretation of the concept of «professional competence». Disclosed the content of the key professional competencies of employees of social service organizations of citizens.
ASSESSMENT OF MODERN THREATS TO RUSSIA'S ECONOMIC SECURITY
Authors: Солдаткина Ольга Александровна , Лапутин Даниил Сергеевич
Published: February 2023

В данной статье дается краткий обзор современных угроз экономической безопасности Российской Федерации в условиях беспрецедентного санкционного давления и ухудшения международных отношений.

This article provides a brief overview of the current threats to the economic security of the Russian Federation in the context of unprecedented sanctions pressure and deterioration of international relations.
THE DENSIFICATION OF "ENERGY-TIME" AS A COSMOPLANETARY PHENOMENON OF KOZYREV SPACE. NOOSPHERE EXPERIMENT IN THE ALTAI MOUNTAINS ON MAY 13, 2019
Authors: Трофимов Александр Васильевич , Иванчук Сергей Викторович , Шимчишина Оксана Викторовна , Кочуров Владимир Сергеевич
Published: February 2023

Синхронная оценка динамики в ходе обряда ритуального пространства, образованного горными породами и их образцами из различных сакральных мест Алтая и пространственно моделированных ячеек, образованных «Зеркалами Козырева».

Synchronous assessment of the dynamics during the ritual of the ritual space formed by rocks and their samples from various sacred places of Altai and spatially modeled cells formed by "Kozyrev Mirrors".