bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH RASIO BAHAN BAKU TEPUNG KOMPOSIT (UBI KAYU, JAGUNG DAN KEDELAI HITAM) PADA KUALITAS PEMBUATAN BERAS ANALOG
Authors: Pudjihastuti Isti , Supriyo Edy , Devara Hafiz Rama
Published: June 2021

The increase population affects an increase in total of consumption of Indonesian people towards rice, which encourages Indonesia to import rice. One of the alternatives that can be done is by using potential non-rice raw materials such as tubers. In this study, the raw materials for composite flour from cassava (Manihot esculenta), corn (Zea mays) and black soybeans (Glycine Sojo) were used, which are the basic ingredient for analog rice. The purpose of this study was to examine the effect of raw material composition on nutritional value (carbohydrate, protein, fat, water and ash content) analog rice compared to ordinary rice, examine the physico-chemistry (kamba density, water absorption and cooking time) of analog rice compare to paddy rice and also to define raw material composition and best temperature, organoleptic test covering color, aroma, texture and taste. The process of making analog rice consists of several stages of research, such as the stage of making composite flour, cooking the composite flour dough, making analog rice, drying analog rice and analyzing the results. The variables used were the ratio of flour composition and the effect of extrusion temperature. Based on proximate analysis on various compositions, obtained sample 5 (60% cassava flour, 15% corn flour and 25% black soybean flour) as analog rice with the best formulation. Based on the proximate analysis of the effect of temperature, the temperature was 75 °C as the optimum temperature for the extraction process. The results of the physical analysis of the best analog rice in this study showed that analog rice from a composite of cassava flour, corn flour and black soybean flour had a kamba density of 0.46 g / mL, a water absorption capacity of 60.52% and a cooking time of 46 minutes. In this sample, analog rice has a texture, aroma and appearance similar to rice in general, although analog rice from composite flour tends to have a savory taste arising from black soybeans.
SURVEI METODE PENGUKURAN APLIKASI CHATBOT BERBASIS MEDIA SOSIAL
Authors: Sekarwati Ratna Ayu , Sururi Ahmad , Rakhmat Rakhmat , Arifin Miftahul , Wibowo Arief
Published: June 2021

The design of Chatbot aims to facilitate social activities in all areas to be considered. Chatbot is one type of machine that can communicate with humans using natural language. Communication happening via chat is a written conversation. Chatbot is a form of application implementation from Natural Language Processing (NLP) that belongs to one branch of artificial intelligence or Artificial Intelligent (AI). Social Media now provides a service that allows developers to process and integrate chatbot applications. This paper aims to review the papers that build chatbot applications in various social media using various testing methods. The contribution of this paper is to determine which method is able to measure the level of chatbot accuracy well. This review paper will choose the equation of the most widely used test methods and social media from various papers so that further research is expected to implement the right testing methods and use better social media in terms of user experience, features, and services. The review paper shows that the Black-box and System Usability Scale testing methods are most used in the review paper. This testing method is a type of method that performs testing of the flow and how the chatbot works to achieve functional validation throughly.
The genetic diversity of heat shock protein 70 gene at promoter and 5' untranslated region in beef cattle
Authors: Suhendro I. , Jakaria J. , Noor R.R.
Published: June 2021

This study was aimed to identify genetic diversity in the promoter area and 5' UTR (untranslated region) HSP70 (heat shock protein 70) gene in several beef cattle in Indonesia. A total of 86 blood samples of Bali, Madura, PO (Peranakan Ongole), Limousine, and BB (Belgian Blue) cattle were used in this study. The extracted DNA of all blood samples was then analyzed using the direct sequencing method. The genotyping results showed the presence of five SNP (Single Nucleotide Polymorphism) in the promoter region, namely g.-393T>C, g.-343C>A, g.-202T>C and g.-69T>G and three SNPs at 5' UTR, i.e., g.19A>G, g.45C>T, and g.100_101ins30. The frequency of SNP alleles found in PO, Limousine, and BB cattle was in equilibrium, whereas in Bali and Madura cattle populations, the allele frequency was disequilibrium. In general, the level of diversity of observed alleles ranged from low to high (0.26-1.00), where SNP g.19A>G had the widest variety. It was successfully revealed in this analysis that the SNP g.-69T>G binds to both the NF-Y and CAAT box transcription factor. In addition, the 30 bp (base pair) insertions (g.100_101ins30) that were identified in Bali and Madura cattle have never been reported in previous research studies.
The interaction of intestinal bacteria and feed: a case study of intensive-duck husbandry in Central Java
Authors: Susanti R. , Dafip M. , Christijanti W. , Yuniastuti A.
Published: June 2021

This study was aimed to compare sugars and amino acid content in duck’s feed and the intestinal bacteria's effects to improve ducks' quality. This research was an observational exploration involving five duck husbandries from Semarang, Temanggung, Magelang, Pati, and Salatiga District, Central Java. A total of 5 g of intestinal contents were collected from each of the five ducks randomly selected from each husbandry. The feed and intestinal contents were then analyzed using high-performance liquid chromatography (HPLC). The highest amino acid types were glutamate, aspartate, lysine, valine, and isoleucine, while the lowest was asparagine found in all sample farms. Intestinal contents freshly extracted then placed in dark bottles sterile for microbiome analysis with primers 6S rRNA V3-V4 genome identification. The concentration of glucose, fructose, and galactose in the intestine has increased significantly caused by digested polysaccharides. The composition of bacteria plays a vital role in digesting polysaccharides, makes them quickly absorbed by duck’s intestine cells. The abundance of bacteria in all sample locations was dominated by the phylum Firmicutes, especially Lactobacilalles, Bacilalles, and Clostridialles. Over feeding may not effective in sugar and essential amino acid absorption, however, it may play an essential role in the diversity of gut bacteria to produce necessary component for duck’s physiology.
PERFORMANS DEĞERLENDİRMEDE KELİMELERİN GÜCÜ: ANLATI YORUMLARI HAKKINDA TEORİK BİR ARAŞTIRMA
Authors: BALTACI Adem
Published: June 2021

Performans değerlendirme yöntemlerinin çoğu, sayısal değerlendirmelerin yanı sıra çalışanla ilgili daha kapsamlı bilgiler sunan “anlatı yorumlarını” da içermektedir. Ancak akademik literatürün büyük bir çoğunluğu sadece sayısal değerlendirmelere odaklanmış, anlatı yorumlarına gereken önem verilmemiştir. Bu kalitatif yöntem, iş performansı ile ilgili sunduğu zengin içerik, nedensellik açıklamaları ve serbest biçimi nedeni ile sayısal değerlendirmelere göre daha avantajlı görülmektedir. Aynı zamanda performans değerlendirmenin değerlendirici ve değerlendirilen arasındaki karşılıklı etkileşime dayanan bir süreç olduğu düşünüldüğünde yorumlar, sayıların dolaysız ve yüzeysel mesajına göre daha kullanışlı görülmektedir. Başka bir ifade ile çalışanın performansının tam resmine ancak anlatı yorumlarındaki ifadelerin açıklayıcı gücü ile ulaşılması mümkündür. Söz konusu önemine rağmen ülkemiz akademik literatüründe, performans yönetimi alanında anlatı yorumlarının neredeyse hiç araştırılmamış olması dikkat çekicidir. Bu noktadan hareketle bu çalışmada anlatı yorumları ile ilgili bir farkındalık oluşturulması amaçlanmış ve konu teorik olarak ele alınmıştır. Yapılan çalışma ile anlatı yorumlarının ne olduğu, önemi, yaygınlaşma nedenleri, sahip olduğu karakteristik özellikler, sayısal değerlendirmelere göre avantajları ortaya konulmuştur. Çalışmanın sonucunda performans değerlendirmenin daha tutarlı ve güvenilir sonuçlar üretebilmesi için anlatı yorumlarının sayısal değerlendirmelerle birlikte kullanılması gerektiği tespit edilmiştir.
The thermostable 4,6-α-glucanotransferase of Bacillus coagulans DSM 1 synthesizes isomaltooligosaccharides
Authors: Xiang Gang , Buwalda Piet L. , van der Maarel Marc J.E.C , Leemhuis Hans
Published: June 2021

The 4,6-α-glucanotransferases of the glycoside hydrolase family 70 can convert starch into isomaltooligosaccharides (IMOs). However, no thermostable 4,6-α-glucanotransferases have been reported to date, limiting their applicability in the starch conversion industry. Here we report the identification and characterization of a thermostable 4,6-α-glucanotransferase from Bacillus coagulans DSM 1. The gene was cloned and the recombinant protein, called BcGtfC, was produced in Escherichia coli. BcGtfC is stable up to 66 °C in the presence of substrate. It converts debranched starch into an IMO product with a high percentage of α-1,6-glycosidic linkages and a relatively high molecular weight compared to commercially available IMOs. Importantly, the product is only partly and very slowly digested by rat intestine powder, suggesting that the IMO will provide a low glycaemic response in vivo when applied as food ingredient. Thus, BcGtfC is a thermostable 4,6-α-glucanotransferase suitable for the industrial production of slowly digestible IMOs from starch.
Quality, Location and Collusion under Spatial Price Discrimination
Authors: Heywood John S. , Wang Zheng
Published: June 2021

We present the first demonstration of the influence of a quality rivalry on location choices under spatial price discrimination. The rivalry is shown to generate the socially efficient quality but to push locations inefficiently close together, a result not found under Hotelling pricing. We apply this new equilibrium to the anti-trust policy issue of collusion showing that introducing the quality rivalry reduces the likelihood of collusion.
Alberto Blest Gana and the Sensory Appeal of Wealth
Authors: Vilches Patricia
Published: June 2021

This essay explores sensory stimuli inLa aritmética en el amor[Arithmetic in Love/Economics of Love] (1860) as they relate to the consumer preferences (for clothing, furniture, jewellery) and purchasing practices of nineteenth-century Santiago, Chile. The novel presents detailed descriptions, for example, of fine fabrics, emphasising the sounds that the wearers of such fabric reproduce as they move about. Wealthy or not, people feel the pressure to present themselves in their best garments, but the “best noise” is made by the rich, who transmit the affect of opulence to the less fortunate. Overall, to radiate a sensory appeal, characters frequent the city of Santiago and patronise the finest clothing stores. From our very first encounter with the protagonist Fortunato Esperanzano, he is dressed accordingly, engaging with Santiago and showing in his persona that he shops only for nice clothes and the best cigars. From a Lefebvrian perspective, Fortunato represents how Chile’s modernisation transforms the capital’s “marketplace” as a social space where a new luxury economy flourishes and a traditional, rigid social order is maintained.
Multi-objective optimal planning of fast charging stations by considering various load models in distribution system
Authors: Battapothula Gurappa , Yammani Chandrasekhar , Maheswarapu Sydulu
Published: June 2021

Electric vehicles (EVs) load and its charging methodologies play a significant role in distribution system planning. The inaccurate modelling of EV load may overload the distribution system components, increase in Network Power Loss (NPL) and Maximum Voltage Deviation (MVD). The Constant Power (CP) load model is more popularly used to model both the conventional and EV loads in the distribution system. But the CP load modelling cannot provide accurate information of EV charging process. In this paper, the EV load is modelled as constant Impedance-constant Current-constant Power (ZIP), Exponential, Constant Current and Constant Power load models and the conventional loads are modelled as Residential–Industrial–Commercial (RIC) and Constant Power load models. With these EV and conventional load models, the optimal site and size of Fast Charging Stations (FCSs) in the distribution system have been determined. Further, to analyse the impact of load of FCSs in the distribution system, the distribution indices are calculated. The multi-objective hybrid SFL-TLBO algorithm has been used to determine the optimal location and size FCSs with the minimization of NPL, MVD and EV User Cost (EVUC) in the distribution system. To consider the uncertainty of the initial SOC of EVs, the Monte-Carlo simulation technique has been used. These studies have been carried out on 38-bus distribution system and substantiate results are presented.
Establishing osteopathic assessments to fulfill osteopathic recognition standards: a model for dermatology and other subspecialties
Authors: Mahlberg Scott J. , Liou Yujie Linda , Lloyd Jenifer
Published: June 2021

The 5 year transition period for American Osteopathic Association (AOA) training programs to apply for and receive Accreditation Council for Graduate Medical Education (ACGME) accreditation (i.e., the single graduate medical education system) was completed June 30, 2020. Of the previously AOA accredited programs that applied for or received osteopathic recognition (OR), only 24.5% are nonprimary care specialty programs according to the ACGME. The reluctance of specialty programs to apply for OR may be because osteopathic principles and practices (OPP) are not assessed. In order for programs to receive OR, they must have a standard method of assessment to assess osteopathic knowledge, including OPP and osteopathic manipulative treatment. In this Commentary, based on our assessment of the results of a literature review, we propose a model to provide a focused osteopathic assessment for the purposes of maintaining OR within residency training based on the ACGME six core competencies. Examples of multiple choice and essay questions are provided, as is a rubric for grading. The model is applied to the field of dermatology in this article and could serve as a blueprint to other subspecialties. With this framework, collaboration among programs will streamline the process to obtain OR in the ACGME single accreditation system.
Road surface influence on electric vehicle noise emission at urban speed
Authors: Cesbron Julien , Bianchetti Simon , Pallas Marie-Agnès , Le Bellec Adrien , Gary Vincent , Klein Philippe
Published: June 2021

Considering the relative quietness of electric motors, tyre/road interaction has become the prominent source of noise emission from Electric Vehicles (EVs). This study deals with the potential influence of the road surface on EV noise emission, especially in urban area. A pass-by noise measurement campaign has been carried out on a reference test track, involving six different road surfaces and five electric passenger car models in different vehicle segments. The immunity of sound recordings to background noise was considered with care. The overall and spectral pass-by noise levels have been analysed as a function of the vehicle speed for each couple of road surface and EV model. It was found that the type of EV has few influence on the noise classification of the road surfaces at 50 km/h. However, the noise level difference between the quietest and the loudest road surface depends on the EV model, with an average close to 6 dBA, showing the potential effect of the road surface on noise reduction in the context of growing EV fleet in urban area. The perspective based on an average passenger EV in a future French or European electric fleet is addressed.
Synthesis and comparative study on the antibacterial activity organotin(IV) 3-hydroxybenzoate compounds
Authors: Hadi Sutopo , Lestari Sri , Suhartati Tati , Qudus Hardoko Insan , Rilyanti Mita , Herasari Dian , Yandri Yandri
Published: June 2021

The synthesis and comparative study on the antibacterial activity of three organotin(IV) compounds, namely dibutyltin(IV) bis-(3-hydroxybenzoate), [Bu2Sn(3-HBz)2] (7), diphenyltin(IV) bis-(3-hydroxybenzoate), [Ph2Sn(3-HBz)2] (8), and triphenyltin(IV) 3-hydroxybenzoate, [Ph3Sn(3-HBz)] (9) which were prepared by the reaction of dibutyltin(IV) oxide, [Bu2SnO] (4), diphenyltin(IV) dihydroxide, [Ph2Sn(OH)2] (5), and triphenyltin(IV) hydroxide, [Ph3SnOH] (6) with 3-hydroxybenzoic acid (3-HBz) has successfully been performed. The characterization of these compounds were done using 1H and 13C NMR, IR, UV spectroscopies and their compositions were determined based on microanalytical data. Antibacterial activity of these compounds was demonstrated at concentrations of 1.89 × 10−4, 1.81 × 10−4, and 1.72 × 10−4 M, respectively by dilution method against Pseudomonas aeruginosa. Similarly, the compounds were active at concentration of 1.87 × 10−4, 1.79 × 10−4, and 1.71 × 10−4 M, respectively, against Bacillus subtilis. These activities are comparable to that of streptomycin at a concentration of 1.70 × 10−4 M as a positive control, but the halozone of compounds 7, 8, and 9 were slightly lower than that of streptomycin’s halozone. The results obtained suggest that the compounds synthesized have potential as antibacterial agents.
PVA coating of ferrite nanoparticles triggers pH-responsive release of 5-fluorouracil in cancer cells
Authors: Mngadi Sanele , Singh Moganavelli , Mokhosi Seipati
Published: June 2021

The use of magnetic nanoparticles (MNPs) has transformed both diagnostics and therapeutic approaches in cancer treatment. Along with developing novel anti-cancer drugs with high therapeutic potential, researchers are exploring innovative strategies for more targeted delivery in order to alleviate the associated potent side effects. In this study, we describe the synthesis of Mg0.5Co0.5Fe2O4 ferrite nanoparticles, their functionalisation with polyvinyl alcohol (PVA), and encapsulation of the anti-cancer drug 5-fluorouracil (5-FU). Functionalised nanoparticles viz. PVA-Mg0.5Co0.5Fe2O4 -5-FU displayed desirable physiochemical properties with regards to the spherical shape, hydrodynamic sizes of <120 nm and relative colloidal stability of up to <−33 mV. The drug encapsulating efficiency was found to be 68%. In vitro cytotoxicity profiles were determined using the MTT and SRB assays, with >65% cell death recorded in MCF-7 and HeLa cancer cell lines. Overall, the nanocomposites exhibited excellent physiochemical elements, high specificity towards cancerous cells and displayed pH-sensitive drug release in a simulated acidic tumour micro-environment. The encapsulation of 5-FU improved bioavailability of the drug in cancer cell lines for a prolonged duration, with the promise to enhance its therapeutic effect, biocompatibility and safety. These MNPs present as promising in vitro delivery systems that can be further developed for therapeutic applications.
Homocysteine is potential serological marker for predicting the risk of deep venous thrombosis of the lower extremities in patients received operation of lower limb fracture
Authors: Chen Xiao , Zhang Weiran , Huang Jingmin
Published: June 2021

Objective

The aim of the study is to investigate the correlations among serum homocysteine (Hcy), D-dimer, and the risk of developing deep venous thrombosis (DVT) of the lower extremities in patients who underwent operation for lower limb fracture.

Methods

Seventy-five cases who underwent operation for lower limb fracture were included and further divided into DVT group (n = 26) and control group (n = 49) based on post-DVT diagnostic criteria. The serum Hcy and D-dimer were examined 48 h after operation. The serum Hcy and D-dimer levels were compared between the two groups. The correlation between serum Hcy and D-dimer was investigated by the Pearson correlation test. The receiver-operating characteristic (ROC) curve was applied to evaluate the diagnostic performance of serum Hcy and D-dimer as serological markers for DVT.

Results

The serum Hcy concentrations were 11.96 ± 3.98 μmol/L and 7.92 ± 3.27 μmol/L for DVT and control groups, respectively, with statistical difference (t = 4.72, P < 0.01). The serum D-dimer in the DVT group was significantly higher than that of the control group (8.99 ± 4.50 vs 1.70 ± 2.11) μg/mL with statistical difference (t = 9.56, P < 0.01). Line regression analysis indicated that serum Hcy was positively correlated with serum D-dimer concentration and can be demonstrated by the equation of Y = 0.6651*X + 1.036 for the DVT group. Using serum Hcy as the biomarker for predicting DVT, the prediction sensitivity and specificity were 76.92 and 71.44%, respectively, with the AUC of 0.7804 under the cut-point of 9.54 μmol/L. For serum D-dimer, the prediction sensitivity and specificity were 96.15 and 73.47%, respectively, with the area under the ROC (AUC) of 0.9455 under the cut-point of 1.66 μg/mL.

Conclusion

Serum Hcy was significantly elevated in DTV patients, and hence, it can be applied as a serological marker for DVT prediction in patients who underwent operation for lower limb fracture. However, the DVT prediction performance of serum Hcy was inferior to D-dimer especially for diagnostic sensitivity.
The efficacy of botulinum toxin A treatment for tension-type or cervicogenic headache: a systematic review and meta-analysis of randomized, placebo-controlled trials
Authors: Roland Sissel Breivold , Pripp Are Hugo , Msomphora Mbachi Ruth , Kvarstein Gunnvald
Published: June 2021

Objectives

The pathogeneses of chronic tension-type headache (CTTH) and cervicogenic headache (CEH) are not well established. Peripheral activation or sensitization of myofascial nociceptors is suggested as a potential mechanism and injections of botulinum toxin (BONTA) have thus been used in the treatment for both headache conditions. BONTA inhibits the release of acetylcholine at the neuromuscular junction and inhibits contraction of skeletal muscles. If the pain is precipitated by increased tone in cervical muscles, local injections of BONTA could represent a prophylactic measure. However, the treatment is still controversial, and a thorough assessment of the current evidence is required. This review aims to assess the evidence of BONTA injection as a prophylactic treatment for CTTH and CEH by reviewing and examining the quality of placebo-controlled, randomized trials.

Methods

Data sources: we searched in the following databases: PubMed (including Medline), Embase, Cochrane Central register of Controlled Trials, Cinahl, Amed, SCOPUS and Google Scholar including other repository sources. Both MeSH and free keywords were used in conducting the systematic search in the databases. The search covered publications from the root of the databases to November 2020.

Study eligibility criteria

The review included RCTs, comparing single treatment of BONTA with placebo on patients with CTTH or CEH above 18 years of age, by measuring pain severity/relief or headache frequency.

Data extraction

The following data were extracted: year of publication, country, setting, trial design, number of participants, injection procedure, BONTA dosages, and clinical outcome measures.

Study appraisal

To assess validity and quality, and risk of bias, the Oxford Pain Validity Scale, Modified Jadad Scale, last version of Cochrane Collaboration’s tool for assessing risk of bias (RoB 2), and the CONSORT 2010 Checklist were used. The trials were assessed, and quality scored independently by two of the reviewers. A quantitative synthesis and meta-analyses of headache frequency and intensity were performed.

Results

We extracted 16 trials, 12 on prophylactic BONTA treatment for CTTH and four on CEH. Of these 12 trials (8 on CTTH and 4 on CEH) were included in the quantitative synthesis. A majority of the trials found no significant difference on the primary outcome measure when BONTA treatment was compared with placebo. Three “positive” trials, reporting significant difference in favor of BONTA treatment, but two of these were hampered by low validity and quality scores and high risk of bias.

Conclusions

There is no clear clinical evidence supporting prophylactic treatment with BONTA for CTTH or CEH.
Pulmonary Function as a Predictor of Frailty Syndrome in Community-Dwelling Older Adults
Authors: dos Santos Nara L. O. , Pegorari Maycon S. , Silva Caroline de F. R. , Jamami Maurício , Matos Areolino P. , Pinto Ana Carolina P. N. , Ohara Daniela G.
Published: June 2021

Background and Purpose:

Diminished pulmonary function is associated with negative health outcomes and pulmonary impairment, and can be associated with frailty. The objectives of this study were to compare pulmonary function between frail, prefrail, and nonfrail older adults; to verify the association between pulmonary function and frailty syndrome; and to establish cut-off points for pulmonary function variables for predicting frailty.

Methods:

A cross-sectional study was conducted with 379 community-dwelling older adults of both sexes. Spirometry was used to measure pulmonary function criteria (forced vital capacity, FVC; forced expiratory volume in 1 second, FEV1; and FEV1/FVC ratio). The presence of frailty was evaluated with Fried's frailty phenotype. Statistical analysis included a multinomial logistic regression model. Pulmonary function cut-off points for discriminating frailty syndrome were established through analysis of the receiver operating characteristic curves.

Results and Discussion:

The study participants were a median of 69.0 (64.0-74.0) years old, and 12.4% presented frailty while 58% presented prefrailty. Frail and prefrail older adults presented significantly lower median FVC and FEV1 values—FVC = 1.89 L (1.45-2.31) and FEV1 = 1.60 L (1.24-1.91); FVC = 2.07 L (1.62-2.67) and FEV1 = 1.66 L (1.32-2.09), respectively—than nonfrail participants—FVC = 2.53 L (1.96-3.16) and FEV1 = 2.01 L (1.54-2.43). The adjusted analysis indicated that FEV1 (odds ratio [OR] = 0.63; 95% confidence interval [CI], 0.39-0.99) and the FVC (OR = 0.68; 95% CI, 0.48-0.96) were inversely associated with prefrailty and that FVC (OR = 0.52; 95% CI, 0.29-0.94) was associated with frailty. Cut-off points for prefrailty (FVC ≤2.3 L and FEV1≤1.86 L) and frailty (FVC ≤2.07 L and FEV1≤1.76 L) were established.

Conclusions:

Pulmonary function was lower in frail and prefrail older adults than in their nonfrail peers. Frailty and prefrailty were inversely associated with pulmonary function. Cut-off points for FEV1 and FVC for discriminating frailty were established and may allow pulmonary function to serve as an indicator of frailty in older adults.
Crucial role of BAALC-expressing leukemic precursors in origin and development of posttransplant relapses in patients with acute myeloid leukemias
Authors: N Mamaev Nikolay , Shakirova Alyena I , Barkhatov Ildar M , Gudozhnikova Yana V , Gindina Tatiana L , Kanunnikov Mikhail M , M Kravtsova Valentina , Z Rakhmanova Zhamal , V Paina Olesya , S Zubarovskaya Lyudmila
Published: June 2021

The presented data are showing the crucial role and great prognostic significance of BAALC-expressing leukemic precursors in origin and development of posttransplant relapses (PTR) in acute myeloid leukemia patients with different cytological variants. For evidence simultaneous serial measurements of BAALC and WT1 transcript copy numbers by means of quantitative real time polymerase chain reaction were used at diagnosis, before conditioning regimen as well as at PTR in 50 patients treated with allogeneic hematopoietic stem cell transplantation (alloHSCT). Thirty-eight of them were adults and twelve pediatric patients aged 1-60 years (median – 25.8 years). It was shown, that BAALC gene overexpression to be presented in all studied cytological and being combined with increased level of WT1 expression at PTR in most of them. This combination was prognostically poor since it is largely associated with increased cumulative incidence of PTR (p<0.0001), and shortened event free (p<0.0001) and overall survival (p=0.002).
Maternal and perinatal outcome in women with hypertensive disorders in pregnancy
Authors: A Lakshmi , DS Akshatha , P Pooja , FG Prashanth , MV Veena , S Sreelatha
Published: June 2021

Aims and objectives To determine the effect of hypertension in pregnancy To determine the maternal and fetal outcome in patients with hypertensive disorders of pregnancy. Materials and methods This is a retrospective study conducted in ESIC MC and PGIMSR, Bangalore from January 2020 to December 2020. All pregnant women who presented with Hypertensive disorder in pregnancy were included in the study. Results A total of 1503 patients who delivered during the study period were included in the study of which 172 patients had hypertensive disorder (11.44 %). Gestational hypertension occurred in 113 cases, preeclampsia in 45 cases, chronic hypertension in 8 cases, chronic hypertension with superimposed preeclampsia in 2 cases and eclampsia in 4 cases. Of these 85(49.41%) cases were primigravida and 87(50.58%) were multigravida. 38 deliveries occurred preterm and 134 were term. 4 patients had intrauterine fetal demise. Gestational diabetes occurred in 30(17.44%) cases, hypothyroidism in 45 cases(26.16%), IUGR in 11 cases(6.39%), oligohydramnios in 10 cases(5.81%). Discussion Hypertensive disorders in pregnancy is a spectrum of disease. It is one of the non communicable diseases occurring in pregnancy. It is the third most common cause of maternal mortality. By timely detection and proper management, it is possible to decrease the complications and adverse outcomes associated with this condition. Conclusion Hypertensive disorders in pregnancy is an important cause for maternal and fetal mortality and morbidity. Hence it is important to identify the risk factors and prevent it for better outcome.
The current state and specifics of taxonomic structure of trematodes of freshwater molluscs in the Ukrainian Polissia
Authors:   Polissia National University (Zhytomyr, Ukraine), Zhytova Olena , Korol Eleonora ,   National Museum of Natural History, NAS of Ukraine (Kyiv, Ukraine)
Published: June 2021

The paper presents results on the analysis of the taxonomic structure of the trematode fauna of the Ukrainian Polissia. It was found that the trematode fauna of freshwater molluscs in the Ukrainian Polissia is represented by 62 species. We supplemented the species composition of larvae of trematodes in the region with 23 species, 13 of which were first recorded in Ukraine. The results showed that the number of trematode species the definitive hosts of which are fishes have decreased. According to the obtained data, the most abundant trematode species of freshwater molluscs in the Ukrainian Polissia are those of the families Echinostomatidae, Plagiorchiidae, Diplostomidae, and Notocotylidae. The combined analysis of literature and original data revealed that in the basis of the regional trematode fauna of molluscs are species of the families Echinostomatidae (13 species) and Plagiorchiidae (10 species), which make up almost one-third of the total number of trematode larvae detected. A quite large portion of larvae belong to species of the families Notocotylidae (8 species), Strigeidae (7 species), Diplostomidae (5 species), and Haematolechidae (5 species). Most families (Diplodiscidae, Opisthorchiidae, Leucochloridiomorphidae, Prostogonimidae, Cathaemasiidae, Cyclocoelidae, Prohemistomatidae, and others) are represented only by 1–2 species. In freshwater molluscs of the studied region, we have found only 38 % of trematode species recorded in definitive hosts. Species found in vertebrate animals of the region potentially can also occur in intermediate hosts, but most of these species parasitize in birds that could be infected in other areas. When comparing the taxonomic structure of the trematode fauna of the Polissia with other well-studied regions of Ukraine (Northern Pryazovia and Crimea), some specifics were noted between them. In particular, it was found that the most abundant trematode species in the region as well as in the whole of Ukraine are those of the families Echinostomatidae, Plagiorchiidae, Diplostomidae, Notocotylidae, and Strigeidae. The obtained data allow considering that the trematode fauna of freshwater gastropods of the Ukrainian Polissia is an integral part of the Central European fauna of trematodes.
On species, its reality and types of species
Authors:   National Museum of Natural History, NAS Ukraine (Kyiv, Ukraine), Zagorodniuk Igor
Published: June 2021

An analysis of the concept of "species" in view of the reality of its existence in the theoretical constructions of eidologists and in the practice of research and description of biotic diversity (BD) is presented. The work includes five main sections. The first considers the concept of species as a designation of individuality (speciesness) in the structure of BD. The etymology and connotations of the terms that were used previously or are used now to denote the category of eidos in Ukrainian, English, and related to Ukrainian Slavic languages are considered (genus, specie[s], kind). The significant influence of the connotative load on dominant species concepts and, in particular, the stable and long-lasting predominance of typology is noted in works of scientists of the 20th century, after the introduction of the term “species”. In the second part, the issue of reality of species and the phenomenon of diversity of its realities, in particular different realities in different contexts, are analysed. It is postulated that the reality of the concept of species is actually determined by the concept of separateness (individuality), three distinct forms of which are proposed: morphological (mostly in museum collections), phyletic (in phylogenetic studies), and biotic (within communities). The third section "On kinds of species and the diversity of species concepts" is devoted to the analysis of systems that describe the diversity of species as concepts, including species categories, kinds (classes) of species, and types of species. The fourth section "Emergent properties of species" discusses emergence and key features of species common for most concepts, as well as biosemiotics as one of the systems for maintaining the integrity of species. Finally, the last (fifth) section deals with the one-dimensional model of "species", the actual concept of "species within a community", when a species is defined not through the closest sister forms (with which it essentially does not intersect anywhere), but through other species with which it is part of the same guilds and communities. It is shown that this aspect of consideration of a species is the closest to its initial interpretation as an object of actual BD within local or regional biotic communities, in which the species is determined through other species with which it coexists and interacts. This significantly distinguishes the species as an element of BD among other interpretations, especially of the phyletic type, in which the species is determined not through ecosystem interactions with sympatric species, but through sister taxa.
Symbol species, days and years of animals in natural history events and museum activities
Authors:   National Museum of Natural History, NAS Ukraine (Kyiv, Ukraine), Zagorodniuk Igor , Ocheretna Kateryna ,   Institute of Zoology NAS of Ukraine (Kyiv, Ukraine),   Kyivo-Pecherskiy Lycee No. 171 “Leader” (Kyiv, Ukraine), Kharchuk Sergiy ,   Ukrainian Theriological Society, NAS Ukraine (Kyiv, Ukraine), Korobchenko Maryna ,   National Museum of Natural History, NAS Ukraine (Kyiv, Ukraine)
Published: June 2021

The paper presents an analytical review of focal animal species as those that are important in sharing natural history knowledge and in the development of environmental initiatives. A detailed analysis of the history and experience of using such animals in the practice of education and museology in the world and in Ukraine is presented. Among the most famous areas of the topic are as follows: 1) attention to wild animals versus attention to domestic ones, 2) formation of a pool of zoo-mascots for different activities and increase the ranking of such species or groups of species, 3) development of zoosymbolism in all forms of activities related to nature (scientific societies, publications, schools-seminars, natural history museums), 4) formation and development of the idea of years of animals (mammal of the year, bird of the year, insect of the year), and 5) formation, share, and development of ideas of special days (bat night, lark day, etc.). The analysis of world and Ukrainian experience showed that the most effective forms of dissemination of knowledge are as follows: 1) production of various small printed products (stickers, calendars, envelopes, stamps, prints), 2) production of more complex forged or minted products (badges, coins, medals), 3) use of paraphernalia on various consumer goods (caps, T-shirts, mugs, balloons, fountain pens, notebooks), 4) holding special promotions, quizzes, contests or quests on thematic days (European Bat Night, International Bird Day, Whale Protection Day), and 5) production and participation in the production of special media products or initiation of social networks (social advertising, documentaries, round tables on the radio and flash mobs on social networks). All these forms of activity can be developed within the "background" work of natural history museums, among them the simplest and least expensive are the days and years of certain animal species that can be performed within the existing exhibitions, complementing such events with interactive forms of work with visitors (competitions, excursions, lectures, presentations of thematic paraphernalia). All this is aimed at sharing knowledge and increasing social attention to the issues of biological diversity, sustainable nature and sustainable community development.
Trends in diagnostic approach of scabies as a neglected tropical disease
Authors: Trasia Reqgi First
Published: June 2021

Scabies is a parasitic disease of the skin that is difficult to enforce if the clinical symptoms are not typical. The diagnosis relies on clinical symptoms to be less efficient and only has a sensitivity of less than 50% because it is difficult to distinguish active infestations, residual skin reactions, or reinfestations. Misdiagnosis results in wrong treatment and causes the patient to not recover and continues to be a source of infection for the environment. The exact diagnosis of scabies is determined by finding mites or eggs on laboratory tests, but mites are difficult to find because only a few mites infest sufferers. For this reason, various studies in the world have tried to develop diagnostic methods in the enforcement of scabies. This article will describe the trend of establishing a diagnosis of scabies, as well as the advantages and disadvantages in its application.
Investigating the relationship between accountability and job satisfaction: A case study in hospitals affiliated to Yazd University of Medical Sciences 2017
Authors: Roohollah Askari , Maryam Hatami Hanza
Published: June 2021

Introduction: high accountability of employees, the organization can be helped to achieve the goals. In general, this research is to investigate the relationship between accountability and job satisfaction in nurses in an educational hospital affiliated to Yazd University of Medical SciencesMethod: This study was a descriptive study of correlation type that has been conducted a cross-sectional study in 2017. We involved 190 nurses from selected educational hospitals affiliated to the Yazd University of Medical Sciences in the city of Yazd that have been chosen by stratified random sampling method. The data collection tool was Costa and M Care Accountability Questionnaire concerning 12 items, and Kendall and Smith Job Satisfaction Questionnaire were 37 items. Likert's 5 scales were used to determine the score of accountability and job satisfaction. The data was analyzed by descriptive-analytical statistical tests and Pearson correlation coefficient, a significance level of 0.05, and in the SPSS software version 20.Results: there was no significant relationship between accountability and job satisfaction except one of job satisfaction (nature of work) (p=0.009). Also, a significant association was observed between three demographic variables of the age group (31-35) years (p=0.047) and work experience between (11-15) years (p=0.03) and the gender of women (p = 0.005) and two variables of accountability and satisfaction.Conclusion: According to the results, it is better to pay more attention to work nature to implement responsibilities more efficiently and increase job satisfaction.
Coronavirus disease 2019 (COVID-19): A case report in a patient with diabetic ketoacidosis and hypertension
Authors: Edy Parwanto Mauritus Lambertus , Digambiro Reza Aditya , Nusantara Dwi Utomo , Rarasati Twindy
Published: June 2021

Background: Until May 2020, Indonesia is still on COVID-19 emergency status. South Jakarta is part of the Special Capital Region of Jakarta that has applied large-scale social restrictions. The Indonesian government has extended Jakarta's large-scale social restrictions to Friday, May 22nd, 2020 to curb the spread of the corona-virus that causes COVID-19.Case report: Patients with diabetic ketoacidosis and hypertension were infected with SARS-CoV-2. He had traveled from Saudi Arabia a week before and already has a fever. Arriving in Indonesia, the patient showed symptoms of worsening disease, experienced coughing, shortness of breath, and sore throat. The patient does not inject insulin due to loss of appetite. On March 30th, 2020, a laboratory examination showed high blood sugar levels (369 mg/dL) followed by positive ketones bodies. On April 2nd, 2020, the patient was designated as a confirmed case of COVID-19 after a positive polymerase chain reaction test. The rapid diagnostic test also showed a positive IgM.Â  Management of patient includes giving O2 through the non-rebreathing oxygen mask, infusion of sodium chloride, 20 IU ApidraÂ®, 12 IU LantusÂ® injection, Oseltamivir orally, Levofloxacin, Paracetamol, Vitamin C, Candesartan, Concor. This therapy was continued until April 5th, 2020. On April 5th, the patient complained about a cold sensation all over his body. The patient died on the afternoon of April 6th, (8 days of hospitalization) due to sudden cardiac arrest and acute respiratory distress syndrome. Cardiopulmonary resuscitation was done with standardized protocol with no avail.Conclusion: Diabetic ketoacidosis and hypertension worsen the condition of COVID-19 patients. There are many unknown disease progression outcomes in these patients.
Role of PRP (platelet-rich plasma) in alopecia areata: A literature review
Authors: Ciptasari Ni Wayan Eka
Published: June 2021

Alopecia areata (AA) is an autoimmune disease that causes hair loss, and its specific cause is notÂ  fully determined. This disease affects the patients physically, psychologically, and cosmetically. Treatment of AA is not curative, but controls or limits the disease course. Most treatment modalities are an immunosuppressive or immunomodulatory agent, which are associated with increased side effects. PRP has been used in aesthetics and dermatology, especially for wound repair. Improvement characterized by hair growth has been reported in several studies. Hair growth improvement with PRP is an effective procedure for AA without any allergic reaction. Epidermal proliferation, induction of angiogenesis, and stimulation of the growth of follicular bulge cells were also reported. Despite showing the efficacy of PRP in AA, it is necessary to carry out randomized clinical trials and long-term evaluations to support the efficacy of therapy.
The effect of duration of wound skin tissue on MDA, TNF-Î±, IL-6, Caspase 3, VEGF levels, and granulation tissue thickness in the white rat (Rattus novergicus)
Authors: Sungkar Amru , Widyatmoko Danar , Yarso Kristanto Yuli , Wasita Brian
Published: June 2021

Introduction: Wound is the result of physical trauma that severs skin continuities. The damage typically causes an inflammatory reaction marked by increase ROS and tissue inflammation. However, this process is still needed to be further investigated. Therefore, this study aimed to evaluate plasma MDA, IL-6, TNF-Î±, Caspase-3 and VEGF levels, and the granulation tissue thickness at different time points during the wound healing process. Methods: An experimental post-test only control group study was conducted using white male rats (Rattus Norvegicus) and the rats were wounded and assessed on day 5 (K1), day 10 (K2), and day 15 (K3). The level of plasma MDA, IL-6, TNF-Î±, Caspase-3 and VEGF level was assessed as well as the granulation tissue thickness.Results: The OneWay ANOVA test results showed significant differences in plasma MDA, IL-6, TNF-Î±, Caspase-3 and VEGF levels (P <0.05). The Tukey HSD test results showed significant differences between (P <0.05) K1 with K2, K1 and K3 and K2 with K3 on MDA plasma, IL-6, TNF-Î±, Caspase-3 and VEGF. However, the granulation tissue thickness was only slightly different between groups and was not significant.Conclusion: The inflammation and angiogenesis were steadily increased overtime during the wound healing process while oxidative stress and cell death were decreasing. However, none of those factors were related to granulation thickness.
Relationship between body mass index, handgrip, and cognitive status on frailty status in elderly women
Authors: Ngestiningsih Dwi , Sukmaningtyas Hermina , Susanto Timothy G , Probosari Enny
Published: June 2021

Background: Decreased health due to the aging process is characterized by a decrease in the function and work of the body's organs which triggers the risk of disability and frailty, especially in postmenopausal women prone to sarcopenia which can worsen the condition of the elderly. The aim of the study is to determine the relationship between body mass index, handgrip, and cognitive status on frailty status in elderly women at some elderly integrated health services (posyandu lansia), Semarang City, Indonesia.Methods: This study used a cross sectional design with a consecutive sampling method of 70 subjects. Subjects measured vital signs, weight and height. Subjects were then assessed for handgrip strength, cognitive status and frailty status. Univariate and bivariate data analysis used SPSS 25.0 with the Spearman correlation test.Results: A total of 70 elderly women followed this study with an average age of 65.96 years. As many as 67.1% of elderly women have hypertension. There are 70% of all elderly women with pre-frail status and 4.3% with frail status. There is no significant relationship between body mass index and frailty status (p=0.328). There is no significant relationship between handgrip and frailty status (p=0.476). There is no significant relationship between cognitive status and frailty status (p=0.664).Conclusion: The elderly women at the some elderly integrated health services, Semarang City mostly have pre-frail status. There is no significant relationship between body mass index, handgrip, and cognitive status on frailty status in elderly women.