bluuebunny/crossref_metadata_2025 huggingface dataset:
The Film in Hand Modes of Coordination and Assisted Virtuosity in the Bombay Film Studios
Authors: Grimaud Emmanuel
Published: January 2022

Less has been said about the hand movements of the film makers, their cultural dimension and the place of this "corporate language" in the film making process, probably because this object is difficult to capture even with a diary. Gestures go too fast to be sketched on the spot and often faster than the perception of the ethnographer. Some of these gestures are made to stabilize the frame or simulate the camera movement but lots of them are difficult to classify and don't fall into this category, like the ones which are produced to accompany the actors' action or to invite him to perform a certain action and which have more to do with a mode of demonstration involving the entire body. This article, mostly based on videos of Bombay film makers at work, tries to identify the specificity of these gestures in terms of communication or interaction and their potential of coordination in the film set dynamics.
”We can’t just do it any which way” – Objectivity Work among Swedish Prosecutors
Authors: Jacobsson Katarina
Published: January 2022

Objectivity is a principle widely acknowledged and honoured in contemporary society. Rather than treating objectivity as an a priori defined category to be tested empirically, I refer to the construction of objectivity as it is accomplished in practice as “objectivity work” and consider how Swedish prosecutors in interviews make and communicatively realize (i.e. “make real”) its claims. In analyzing two facets of objectivity work – maintaining objectivity and responses to objectivity violations – seven mechanisms are identified: appeals to (1) regulation, (2) duty, and (3) professionalism; responses to violations by (4) incantations of objectivity, (5) corrections, (6) proclamation by contrast, and (7) appeals to human fallibility. Directions for future research emphasize cross-cultural and crossoccupational comparisons, not only within the judiciary as objectivity is of a general concern in any area where disinterested truths are claimed. The concept of objectivity work allows one to study how various actors bring principle into everyday life.
American Social “Reminders” of Citizenship after September 11, 2001: Nativisms and the Retractability of American Identity
Authors: Fong Jack
Published: January 2022

My discussion considers how crisis dramatically changes social relationships and interaction patterns within a multicultural context. Specifically, I note the inherent social asymmetry of multicultural configurations, thus rendering it vulnerable for the dominant ethnic/racial group, the ethnocracy, to exact symbolically and materialistically punitive measures against minorities during periods of national crisis. I situate my discussion of dramatically changed social interactions in the post- September 11, 2001 period, when the attacks on the World Trade Center towers triggered nativism against Arab Americans, or any group phenotypically similar to the construction of “Arab.” I note how this nativism is not new but is a historical and consistent articulation of the ethnocratic stratum that retracts the American identity and notions of citizenship away from minorities during times of national crisis. The discussion concludes with how American multiculturalism is still full of unresolved ethnic and racial symbolisms that hark back to nineteenth century attempts by the White power structure to idealize, culturally and phenotypically, the constitution of an “ideal” American.
Multiple-role perspective on assessing teaching ability: reframing TVET teachers’ competency in the information age
Authors: Diao Jun-feng , Yang Juan
Published: January 2022

In the information age, technology has changed people's lives as well as working and learning styles. The teaching competency of vocational teachers’ is facing new challenges. Based on the modernization of vocational education, "Internet + Vocational Education", and "reform of teachers, teaching materials and teaching methods", the study intends to enrich the research on vocational teachers’ teaching competency theoretically by establishing the framework, criteria and assessing instrument. In practice, the study aims to provide benchmarks and tools for the diagnosis and assessment of vocational teachers’ teaching competency. Furthermore, the study wishes to provide guidelines for vocational teachers' professional development and improve the quality of the ICT teaching practice.
Integration of character education based on local culture through online learning in Madras Ahaliyah
Authors: Muhammad AR , Suhaimi Suhaimi , Zulfikar Teuku , Sulaiman Sulaiman , Masrizal Masrizal
Published: January 2022

The focus of this article's discussion is related to the integration of character education based on local culture at Madrasah Aliyah (Senior High School) in Aceh. The participants were determined purposively, and they were six Madrasah principals, and 50 teachers served at Madrasah Aliyah (Islamic secondary school ) throughout Aceh. The data were analyzed following the procedures of qualitative research. The results of the study suggest that the integration of character education based on local Acehnese culture was carried out through integration in learning, the preparation of a Characteristic Learning Implementation Plan (RPP) module, the role of the teacher as a role model, and the development of pesantren (boarding school) culture. The integration of character education based on local wisdom at Madrasah Aliyah in Aceh has implications for student character development, such as religion, integrity, critical thinking, independence, participating in social activities, and responsibility. Furthermore, the implementation of character education in the conditions of the Covid-19 pandemic was carried out through a distance-learning system (online). However, the use of this system still faces technical problems, but as a whole, it can be implemented effectively.

Keywords: Character building, Integration, Online Learning, Covid-19
ISLAMIC EDUCATION DEVELOPMENT BASED ON UNITY OF SCIENCES PARADIGM
Authors: Junaedi Mahfud , Wijaya Mirza Mahbub
Published: January 2022

The focus of this research lies in the philosophical analysis of Islamic education based on the Unity of Sciences paradigm. So far, no researcher has studied this issue specifically and comprehensively. This study uses a philosophical and phenomenological approach of library research. The finding shows that the development of managed Islamic education has both human and divine potential. Unity of Sciences has become the basis for creating a balanced Islamic education paradigm with humanization and spiritualization strategies. Therefore, development of Islamic education based on Unity of Sciences can produce modern scientists who are religious and not anti-local culture. Thus, this paradigm encourages scientists to dialogue and reciprocally lead someone closer and closer to God, the Most True (al-Ḥaqq). This paradigm is implemented into the curriculum at State Islamic University (UIN) Walisongo Semarang.
Pengujian Unit Plugin Pemberian Anotasi Efek Secara Semantik pada Proses Bisnis BPMN
Authors: Nuril Hadi Hilman
Published: January 2022

Business process model was created to make it easier for business process stakeholders to communicate and discuss the structure of the process more effectively and efficiently. Business process models can also be business artifacts and media that can be analyzed further to improve and maintain organizational competitiveness. To analyze business processes in a structured manner, the effect/results of the execution of business processes will be one of the important information. The effect/result of the execution of certain activities or a business process as a whole are useful for managing business processes, including for improvements related to future business processes. This effect annotation approach needs to be supported by business process modeling tools to assist business analysts in managing business processes properly. In previous research, the author has developed a plugin that supports business analysts to describe the effects semantically attached to activities in the Business Process Model and Notation (BPMN) business process model. In this paper, the author describes the unit testing process and its results on the plugin of semantic effect annotation that have been developed. Unit testing was carried out using the basic path testing technique and has obtained three test paths. The results of unit test for plugin are also described in this paper.
Analisis Keamanan Sistem Informasi Akademik (SIAKAD) Universitas XYZ Menggunakan Metode Vulnerability Assessment
Authors: Alwi Erick Irawadi , Ilmawan Lutfi Budi
Published: January 2022

The use of academic information systems (siakad) has become mandatory for universities in providing user convenience in online academic administrative activities. However, sometimes college siakad has security holes that irresponsible people can take advantage of by hacking. This study aims to identify security vulnerabilities at XYZ Siakad University.

The method used in this study is a vulnerability assessment method. A university syakad will conduct an initial vulnerability assessment by doing footprinting to get information related to XYZ syakad after that a vulnerability scan is carried out using vulnerability assessment tools to identify vulnerabilities and the level of risk found.

Based on the vulnerability of the XYZ university's vulnerabilities, it is quite good, with a high risk level of 1, a medium risk level of 6 and a low risk level of 14. Researchers provide recommendations for improvements related to the findings of security holes in XYZ university Siakad from XSS (Cross Site Scripting) attacks, Clickjacking, Brute Force, Cross-site Request Forgery (CSRF) and Sniffing.
PROXIMATE COMPOSITION OF Reinwardtiodendron humile (Hassk.) Mabb. FRUIT FROM BOGOR BOTANIC GARDENS COLLECTION
Authors: Solihah Saniyatun Mar'atus , Astuti Inggit Puji
Published: January 2022

Abstract

 

Reinwardtiodendron humile (Hassk.) Mabb. is one of the members of the Meliaceae tribe with the potential to be developed and consumed as fresh fruit or processed fruit. This research aims to determine the proximate composition or nutritional values contained in R. humile. Proximate analysis of R. humile included analytical determinations of water, ash, crude fat, protein, crude fibre, and carbohydrates. All tests for each of the parameters or components were carried out two times. Then, the contents determined through proximate tests were calculated using certain formulas. The results of this study indicate that the proximate composition of R. humile consisted of water, ash, fat, protein, crude fibre, and carbohydrates (74.2% - 75.28%; 1.35% - 1.54%; 0.53% - 0.72%; 2.48% - 2.73%; 0.86% - 3, 47%; and 16.7% - 20.14%). These results meant the fruit contents met the quality standards of fruit, except for the protein content. The results of the analysis of the proximate composition also show that the nutritional values of R. humile fruit did not significantly differ from the nutritional values of other fruits of the Meliaceae tribe commonly consumed by humans, such as duku, langsat, and kokosan.

 

Keywords: fruit, nutritional value, proximate analysis, Reinwardtiodendron humile
AKTIVITAS ANTI BAKTERI NANO PARTIKEL PERAK (NPP) HASIL BIOSINTESIS MENGGUNAKAN EKSTRAK KELADI SARAWAK Alocasia macrorrhizosTERHADAP Staphylococcus aureus DAN Escherichia coli
Authors: Masykuroh Athiah , Puspasari Heny
Published: January 2022

Biosintesis Nano partikel perak (NPP) pada penelitian ini dilakukan dengan bantuan ekstrak air tanaman keladi sarawak Alocasia macrorrhizos sebagai bioreduktor dengan variasi konsentrasi larutan AgNO3 sebesar 0,05 M ; 0,10 M dan 0,15 M. Studi keberhasilan pembentukan NPP didasarkan pada pengamatan perubahan warna dan terbentuknya Surface Plasmon Resonance (SPR) dengan bantuan instrumen Spektofotometer UV-Visibel dan Scanning Electron Microscope (SEM). Uji Aktivitas antibakteri dilakukan dengan metode difusi kertas cakram. Hasil analisis menunjukkan bahwa NPP terbentuk maksimum pada panjang gelombang maksimum 450,00 nm yaitu pada variasi konsentrasi larutan AgNO3 0,15 M. Uji morfologi menggunakan SEM menunjukkan partikelnya berbentuk batang (nanorods) dengan ukuran diameter rata-rata masing-masing variasi 826,44 nm (0,05 M), 283,44 nm (0,10 M) dan 266,33 nm (0,15 M). NPP hasil biosintesis menunjukkan aktivitas antibakteri terhadap kedua jenis bakteri Staphylococcus aureus dan Escherichia coli pada pengenceran konsentrasi masing-masing variasi NPP sebesar 50%.
Kata kunci :nanopartikel perak, keladi sarawak, staphylococcus aureus, escherichia coli
KEANEKARAGAMAN TUMBUHAN SUKU PIPERACEAE DI KAWASAN AIR TERJUN LOMBONGO PROVINSI GORONTALO
Authors: Baderan Dewi , Baderan Dewi Wahyuni K , Kumaji Syam S
Published: January 2022

Tumbuhan suku Piperaceae merupakan kelompok tumbuhan berbunga yang mempunyai ciri khas aromatik dan hidup di daerah hutan hujan tropika. Berdasarkan survei awal di kawasan air terjun Lombongo Provinsi Gorontalo, wilayah Taman Nasional Bogani Nani Wartabone, didapati berbagai spesies dari suku Piperaceae. Namun belum teridentifikasi jenis Piper apa saja serta bagaimana nilai indeks keanekaragaman di kawasan air terjun tersebut. Tujuan penelitian ini adalah untuk mengetahui bagaimana keanekaragaman jenis tumbuhan suku Piperaceae yang ada di kawasan air terjun Lombongo Provinsi Gorontalo. Teknik pengumpulan data menggunakan metode eksploratif atau jelajah dengan menggunakan teknik sampling Probability Sample. Hasil penelitian menemukan 9 jenis tumbuhan suku Piperaceae dengan dua cara hidup yang berbeda yakni, terstrial dan epifit. Nilai indeks keanekaragaman tumbuhan suku Piperaceae yang terdapat di kawasan air terjun Lombongo adalah 2.17 dengan kriteria sedang yang menunjukan keadaan ekosistem yang cukup stabil.
Peran Metode Bercerita terhadap Perkembangan Bahasa Anak Usia Dini
Authors: Hartati Sri , Damayanti Eka , Rusdi T M , Patiung Dahlia
Published: January 2022

Perkembangan bahasa merupakan salah satu aspek yang sangat penting distimulasi pada anak usia dini. Penelitian ini bertujuan untuk memaparkan peran metode bercerita terhadap perkembangan bahasa anak usia dini. Penelitian ini menggunakan metode studi pustaka. Sumber data yang digunakan berupa 11 jurnal yang sesuai dengan kriteria fokus penelitian. Teknik analisis data menggunakan analisis deskriptif model Miles Huberman. Hasil penelitian menggambarkan metode bercerita dapat meningkatkan perkembangan bahasa anak usia dini khususnya kemampuan bicara. Peningkatan tersebut diperoleh karena penyajian metode bercerita menggunakan media buku yang berwarna-warni sehingga menyenangkan dan mengasyikan serta melatih kemampuan bicara dengan keberanian tampil bercerita di depan kelas. Metode bercerita juga menarik karena menggunakan media boneka tangan, media power point dan media audiovisual. Metode bercerita juga dapat meningkatkan kemampuan menyimak dan kemampuan kosakata anak dengan menggunakan tema yang beragam, kalimat yang sederhana dan mudah dipahami oleh anak. Implikasi dalam penelitian ini adalah metode bercerita berperan terhadap perkembangan bahasa anak usia dini. Oleh karena itu, diharapkan bagi pendidik menggunakan berbagai metode yang kreatif dan inovatif dalam membantu proses pembelajaran agar tujuan pembelajaran dapat tercapai dengan baik, selain itu tercipta suasana gembira dan tidak cepat membosankan bagi anak saat belajar.
Pengaruh Regulasi Emosi terhadap Interaksi Sosial Selama Pembelajaran Home Visit Akibat Pandemi COVID-19 di TK B
Authors: Amelia Rizky Eka , Rahmawati Anayanti , Fitrianingtyas Anjar
Published: January 2022

Tujuan penelitian untuk mengetahui pengaruh regulasi emosi terhadap interaksi sosial selama pembelajaran home visit akibat pandemi COVID-19 di TK B. Metode pengumpulan data penelitian melalui kuesioner, berdasarkan penilaian guru terhadap 76 anak. Subjek penelitian menggunakan total sampling, melibatkan anak usia 5-6 tahun di TK Aisyiyah 20 Pajang. Pengambilan data penelitian menggunakan instrumen translasi ERC (Emotion Regulation Checklist) dan IRSC (Interaction Rating Scale for Children), yang telah di uji coba terlebih dahulu untuk mengetahui hasil valid dan reliabel. Teknik analisis data menggunakan uji regresi linear sederhana melalui SPSS 25,00 for windows. Hasil penelitian bahwa data koefisien dinyatakan signifikan, dengan nilai signifikansi (Sig.) sebesar 0,040 lebih kecil dari probabilitas 0,05. Hasil perhitungan nilai signifikansi Asiymp.Sig (2-tailed) sebesar 0,065 lebih besar dari 0,05. Nilai pengaruh regulasi emosi terhadap interaksi sosial sebesar 5,6%.
Kepercayaan Diri Anak Usia 4-5 tahun yang Mengikuti Ekstrakurikuler Tari Melalui Tari Karapan Sapi
Authors: Irani Indira , Adhani Dwi Nurhayati , Yuniar Dias Putri
Published: January 2022

Tujuan penelitian ini adalah untuk mendeskripsikan kepercayaan diri anak dan faktor-faktor yang mempengaruhi kepercayaan diri anak yang berusia 4-5 tahun melalui kegiatan tari karapan sapi. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan deskriptif. Subjek penelitian yaitu 3 anak kelompok A berusia 4-5 tahun yang mengikuti ekstrakurikuler tari di TK Negeri Pembina Bangkalan. Teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Analisis data menggunakan teknik analisis data model Miles dan Huberman ada tiga tahap yaitu reduksi data, penyajian data dan penarikan kesimpulan atau verifikasi. Hasil penelitian kepercayaan diri anak usia 4-5 tahun melalui kegiatan tari karapan sapi yaitu keyakinan diri pada ketiga subjek sudah memiliki keyakinan dalam melakukan gerakan tari yang diberikan tetapi masih melihat anak lain di sampingnya dan masih dengan bantuan arahan pelatih tari, untuk keberanian pada ketiga subjek sudah berani mencoba gerakan-gerakan tari yang diberikan dan berani tampil didepan kamera tanpa bantuan arahan pelatih tari dan sikap positif pada ketiga subjek sudah pantang menyerah saat berlatih tari dengan mencoba dan mencoba lagi gerakan tari yang diberikan dengan sikap yang bersemangat tanpa bantuan arahan pelatih tari. Faktor-faktor yang mempengaruhi kepercayaan diri anak yaitu konsep diri dan harga diri karena ketiga subjek sudah menyadari kelebihannya bahwa bisa menari dan menyadari kekurangannya dengan menerima kritik dan mau memperbaiki gerakan tarinya, dan juga pengalaman ketiga subjek sudah pernah menampilkan tari saat pentas seni sekolah, dan terakhir pendidikan ketiga subjek masih kurang pengetahuan dalam makna tari yang diberikan.
PIDANA PERINGATAN DALAM KERANGKA PERLINDUNGAN ANAK
Authors: Diarsa Trian , Sarwirini Sarwirini
Published: January 2022

Undang-undang Republik Indonesia Nomor 11 Tahun 2012 tentang Sistem Peradilan Pidana Anakmemuat sanksi baru yang tidak ditemukan dalam undang-undang sebelumnya salah satunya yakni pidana peringatan. Namun demikian setelah 7 tahun berlakunya undang-undang tersebut belum ada peraturan pelaksana yang mengaturdengan jelas mengenai pelaksanaan  pidana peringatan yang dapat dijatuhkan kepada anak. Hal ini mengakibatkan tujuan dicantumkan pidana peringatan dalam Undang-undang Sistem Peradilan Pidana Anak tidak dapat diketahui secara pasti. Padahal secara umum tujuan diundangkannya Undang-undang Sistem Peradilan Pidana Anak adalah mengatur secara komprehensif perlindungan kepada anak yang berhadapan dengan hukum. Dengan menggunakan metode hukum normatif, penelitian ini akan mencari hakikat dari pidana peringatan dihubungkan dengan perlindungan anak.
A Cut-Cell Polyhedral Finite Element Model for Coupled Fluid Flow and Mechanics in Fractured Reservoirs
Authors: Shovkun I , Tchelepi H. A.
Published: January 2022

Mechanical deformation induced by injection and withdrawal of fluids from the subsurface can significantly alter the flow paths in naturally fractured reservoirs. Modeling coupled fluid flow and mechanical deformation in fractured reservoirs relies on either sophisticated gridding techniques or enhancing the variables (degrees of freedom) that represent the physics to describe the behavior of fractured formation accurately. The objective of this study is to develop a spatial discretization scheme that cuts the “matrix” grid with fracture planes and utilizes traditional formulations for fluid flow and geomechanics.

The flow model uses the standard low-order finite volume method with the compartmental embedded discrete fracture model (cEDFM). Due to the presence of nonstandard polyhedra in the grid after cutting/splitting, we use numerical harmonic shape functions within a polyhedral finite element (PFE) formulation for mechanical deformation. To enforce fracture-contact constraints, we use a penalty approach.

We provide a series of comparisons between the approach that uses conforming unstructured grids and an unstructured discrete fracture model (uDFM) with the new cut-cell PFE formulation. The manuscript validates and compares both methods for linear elastic, single-fracture slip, and Mandel’s problems with tetrahedral, Cartesian, and perpendicular-bisectional (PBI) grids. Finally, the paper presents a fully coupled 3D simulation with multiple inclined intersecting faults activated in shear by fluid injection, which caused an increase in effective reservoir permeability.

Our approach allows for great reduction in the complexity of the (gridded) model construction while retaining the solution accuracy together with great savings in the computational cost compared with uDFM. The flexibility of our model with respect to the types of grid polyhedra allows us to eliminate mesh artifacts in the solution of the transport equations typically observed when using tetrahedral grids and two-point flux approximation.
Modeling wind drift and evaporation losses during sprinkler irrigation in arid areas (case of Touggourt - Algeria)
Authors: Gheriani Sofiane , MEZA Noureddine , BOUTOUTAOU Djamel
Published: January 2022

In recent years, agriculture development in South-eastern Algeria progressed rapidly which increased the demand for agricultural products. Given that this region is characterized by hard agro-climatic conditions, irrigation seems to be a necessary factor for ensuring optimal development and high agricultural production. Like many irrigation technics widely used, sprinkler irrigation performance was considerably affected by these conditions, mainly evaporation, which causes water losses. This study aims to propose an adequate mathematical model predicting wind drift and evaporation losses under different weather conditions resume by the complex indicator of climatic intensity (ɸ). Results showed that complex indicators of climatic intensity, were significant factors affecting the wind drift and evaporation losses, puissance relationship between wind drift and evaporation losses, and complex indicators of climatic intensity, obtained model are adopted can be useful tools in the determination of the overall losses in terms of environmental conditions (air temperature, relative humidity, and wind speed). Totally 25 measure samples were used for training the model, and 15 measure samples for testing and validation of the model. The developed model for the WDEL modeling shows high good performance with a coefficient of determination (R2) = 0.808, mean squared error (RMSE) = 3.39%, and Mean Absolute Error MAE = 8.41%.
Exploring Polycrystalline Materials: High-throughput Phase Elucidation Using Serial Rotation Electron Diffraction
Authors: Luo Yi , Wang Bin , Smeets Stef , Sun Junliang , Yang Weimin , Zou Xiaodong
Published: January 2022

Rapidly and reliably elucidating the phases in polycrystalline materials is essential for developing new materials. Yet, crystals of many materials of chemical, pharmaceutical, or industrial interest are too small for routine X-ray diffraction analysis. This can be workflow bottlenecks in material development, especially in high-throughput synthesis screenings. With the increased prevalence of electron diffraction, we explore a series of zeolite syntheses, resulting in polycrystalline products, via high-throughput phase identification using serial rotation electron diffraction (SerialRED). Five zeolite phases were identified in one product, the most complex mixture ever discovered in zeolite chemistry. Some of the phases are of ultra-low contents, similar unit cells, and/or identical morphologies. Via automatically examining hundreds of crystals, SerialRED enables the reliable and high-throughput phase analysis of products that X-ray diffraction cannot handle. It allows the exploration of more complex synthesis systems and provides new opportunities for rapidly developing novel materials, greatly benefiting synthesis chemistry and material science.
Investigation of The Driving Factors of Ecological Footprint in Malaysia
Authors: Kalmaz Demet Beton , Awosusi Abraham Ayobamiji
Published: January 2022

Malaysia’s growing trends in energy production related emissions throw doubt on the country's possibility of meeting the Paris Climate Change Agreement and SDG obligations. Taking into account Malaysia’s current growth pattern and climatic circumstances, this study evaluates the association between ecological footprint and its potential determinants: economic growth, oil consumption, renewable energy and domestic capital investment for the period between 1965 and 2017. The stationary nature of the parameters is investigated using the conventional unit root approach (ADF and PP unit root) and structural break unit root (ZA unit root). The bounds approach in combination with the critical approximation p-values of Kripfganz and Schneider (2018) established a cointegration association between the observed parameters. The ARDL approach uncovered that economic growth and oil consumption contribute to ecological footprint. Furthermore, renewable energy consumption and gross capital formation reduce the ecological footprint. The FMOLS and DOLS estimators were applied as the sensitivity analysis of the ARDL estimators. Furthermore, the spectral BC causality approach was also utilized to investigate the causal association between ecological footprint and its determinants.
Satellite-Based Precipitation Estimates Validation Using Surface Stations in the Central Region of the State of São Paulo, From 1981 to 2019
Authors: Santos Bruno César dos , Sanches Rafael Grecco , Bolleli Talyson de Melo , de Souza Paulo Henrique , Bourscheidt Vandoir
Published: January 2022

With the advance of remote sensing technologies, meteorological satellites have become an alternative in the process of monitoring and measuring meteorological variables, both spatially and temporally. The present study brings some additional elements to the validation of satellite-based precipitation estimates by evaluating the CHIRPS (Climate Hazards Group Infra-Red Precipitation with Station) monthly product for the central region of the state of São Paulo, Brazil, in the period 1981-2019. Initially, the general relationship between satellite estimates and surface rainfall data is assessed using the linear adjustment and error analysis in both temporal and spatial perspectives, followed by a trend analysis using Laplace test. The monthly map analysis showed a better performance of CHIRPS during the dry period (April to August) than for the wet period (October to March). Finally, monthly trends showed, in general, the same pattern of variability in rainfall over 38 years and a prevalence toward the reduction of rainfall. In summary, CHIRPS product seems a reasonable alternative for regions that lack historical rainfall information.
Real-World Prescribing Pattern of Asthma Management in China: A Retrospective, Descriptive Analysis
Authors: Sun Jian , Wang Xin , Ma Xiaobin , Feng Yuyu , Wang Yajun , Wang Junren , Jiang Shujuan , Xing Chunyan
Published: January 2022

Background

Asthma is a chronic inflammatory disorder of the airway that requires long-term medication management.
Objective

To describe the real-world prescribing patterns for asthma management in the Chinese population.
Methods

A retrospective analysis of 8,732 patients from January 2011 to September 2019 in 10 hospitals was conducted. Prescribing patterns of short-acting beta-agonists (SABA), long-acting beta-agonists (LABA), inhaled corticosteroids (ICS), intravenous corticosteroids, antihistamines, leukotriene receptor antagonists (LTRA), theophylline, antibiotics, and Chinese patent medicines were included in the analysis. Chi-square and logistic regression were calculated. P value of <0.05 was considered as statistical significance.
Results

ICS/LABA were prescribed for 2,940 (33.67%) patients with stable asthma and 141 (31.4%) patients with asthma exacerbations. LTRA was prescribed in 2,006 (22.97%) patients with stable asthma, and 86 (19.15%) patients with asthma exacerbations. Systemic antibiotics (46.1Z%), systemic corticosteroids (57.91%), and theophylline (51.45%) were frequently prescribed during exacerbations. A total of 5,766 patients (64.95%) were managed with traditional Chinese medication (TCM); 3237 patients (36.47%) received western medicine. Patients using ICS/LABA (P=0.019) and SABA (P=0.008) had a significantly lower rate of asthma exacerbations.
Conclusions

This study provides valuable insight into clinical practices of asthma management in China. Poor adherence to clinical reports was identified. Efforts are required to improve the quality of asthma care.
Reverse-Zoonotic Transmission of SARS-CoV-2 Lineage Alpha (B.1.1.7) to Great Apes and Exotic Felids in a Zoo in the Czech Republic
Authors: Nagy Alexander , Stara Martina , Vodička Roman , Černíková Lenka , Jiřincová Helena , Křivda Vlastimil , Sedlák Kamil
Published: January 2022

We report an outbreak of SARS-CoV-2 lineage alpha in gorillas and felid species in a zoo in Prague, Czech Republic. The course of illness and clinical signs are described, and the particular SARS-CoV-2 variants are characterized by next generation sequencing and phylogenetic analysis. The putative transmission routes are also inferred.
Ultrasound-Guided Lumbar Plexus Block Reduces Emergence Agitation in Children Undergoing Hip Surgery: A Prospective Randomized Controlled Trial
Authors: Zhang Hui , Zhang Junfeng , Wang Xiaofeng , Xu Tao , Yan Hai , Yang Yonggang , Chen Yongzhu , Jiang Wei , Fan Qing , Wang Aizhong
Published: January 2022

Background
Emergence agitation (EA) is a common and challenging postoperative problem in children emerging from general anesthesia. It is associated with self-injury, increases stress on healthcare team members and postoperative maladaptive behavioral changes. However, no completely effective prevention has been found for EA. Pain is considered to be an important contributor to EA. Ultrasound-guided lumbar plexus block is a safe and effective anesthetic technique that can provide satisfactory pain relief in pediatric hip surgery. We aim to investigate the effect of ultrasound-guided lumbar plexus block on emergence agitation in children undergoing hip surgery.
Methods
This prospective, randomized, controlled study was conducted in children aged 1-6 yr undergoing elective hip surgery. Subjects were randomly assigned to receive either ultrasound-guided lumbar plexus block combined with general anesthesia (Group Block, n=60) or routine general anesthesia (Group Control, n=60). The primary outcome was the incidence of EA at 30 min after emergence from general anesthesia, assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale. The secondary outcomes included the incidence of severe EA, postoperative pain evaluated by the Children’s Hospital of eastern Ontario Pain Scale (CHEOPS) and the incidence of postoperative adverse complications. PAED, CHEOPS were measured at 0, 5, 10, 20, and 30 min after emergence from anesthesia.
Results
The incidence of EA was significantly lower in Group Block than in Group Control [13.3% vs. 43.3%, odds ratio (OR) 0.201, 95% confidence interval (CI) 0.082to 0.496, p<0.001]. Group Block had a lower incidence of severe EA than Group Control [3.3% vs. 18.3%, odds ratio (OR) 0.154, 95% confidence interval (CI) 0.032 to 0.727, p=0.019]. CHEOPS was lower in Group Block than in Group Control [mean (95%CI), 4.5(4.4-4.6) vs.4.9 (4.8-5.0), p<0.001].
Conclusion
Ultrasound-guided lumbar plexus block could decrease the incidence and severity of emergence agitation in children undergoing hip surgery effectively.
Trial registration:
Chinese Clinical Trial Registry: ChiCTR-INR-17011525 (30/05/2017)
Comprehensive Characterization And Clinical Relevance of CLEC4G Expression Across Human Cancers
Authors: Li Yong , Huang Huiqin , Ye Xiangli , Li Xiaoping , Huang Zhenghui , Gong Longlong , Wu Feng
Published: January 2022

Liver and lymph node sinusoidal endothelial cell C-type lectin (CLEC4G) interacts with the surface glycoproteins of enveloped viruses and mediates immune evasion for viruses. Recent studies have indicated that the expression of CLEC4G affects the development and microenvironment of tumors. In the present study, we revealed comprehensive characterization of CLEC4G expression across human cancers. We first explored the effect of CLEC4G expression on overall survival (OS) across human cancers. High expression of CLEC4G was beneficial in lung adenocarcinoma (LUAD) and detrimental in kidney renal clear cell carcinoma (KIRC) and uveal melanoma (UVM) in terms of OS. Enrichment analysis of the 14 cancer-related signatures suggested that CLEC4G regulated tumor metastasis and immune response. Enrichment analysis of the immunophenotypes and cancer-immunity cycles indicated that CLEC4G was involved in regulation of macrophages and Treg cells, which affected tumor immune response. We also observed correlations between CLEC4G expression and checkpoint molecular expression in different cancer types. Taken together, the present study revealed the comprehensive characterization of CLEC4G expression across human cancers, predicting the roles of CLEC4G in the development and immune microenvironment of tumors.
Does the Conjunctivochalasis Accompanied by Pseudoexfoliation Syndrome Affect the Ocular Surface and Anterior Segment Structures?
Authors: Özen Bediz , Öztürk Hakan
Published: January 2022

Purpose: Probability of coexistence of conjunctivochalasis and pseudoexfoliation syndrome (PES) in same individual may increase with aging. We investigated effects of conjunctivochalasis accompanied by PES on ocular surface (OS) and anterior segment (AS) structures.Methods: Cases with only conjunctivochalasis were determined as group-1 (n=62), cases with conjunctivochalasis accompanied by PES as group-2 (n=45), and healthy cases as group-3 (n=56). OS and AS parameters of groups were compared.Results: Compared to group-1, group-2 had higher grade-3 conjunctivochalasis (17.7% vs 46.7%, p=0.039), greater mean grade of conjunctivochalasis (MGC) (1.72±0.24 vs 2.29±0.32, p=0.036), higher total conjunctivochalasis score (TCS) (4.27±1.13 vs 6.12±1.35, p=0.025), shorter tear-film break-up time (TBUT) (9.17±2.53 vs 5.41±1.32, p=0.010), greater OS disease index (OSDI)-score (16.28±3.15 vs 27.36±4.12, p=0.037). Compared to group-3, both group-1 and group-2 had shorter TBUT (group 3-1: p=0.004; group 3-2: p<0.001) and greater OSDI score (group 3-1: p=0.042; group 3-2: p=0.019). Schirmer tests, central corneal thicknesses, keratometries, axial lengths, anterior chamber depths and lens thicknesses of groups were similar (p>0.05). In group-1 and group-2, as age increased, both MGC (r=0.349, p=0.043; r=0.403, p=0.022, respectively) and TCS (r=0.322, p=0.046; r=0.372, p=0.031) increased. In group-2, as both MGC and TCS increased, TBUT (r=-0.370, p=0.034; r=-0.401, p=0.025) decreased and OSDI score (r=0.338, p=0.045; r=0.362, p=0.040) increased.Conclusions: To our knowledge, this was the first study comprehensively investigating effects of conjunctivochalasis accompanied by PES on OS and AS structures together. We found that conjunctivochalasis might cause OS disease, while presence of PES in conjunctivochalasis cases might worsen OS disease and conjunctivochalasis findings.
Association Between Depression and Breast Cancer: TNF/TNFRSF1β and LEP/LEPR Axis
Authors: Lin Jiaying , Cui Guangman , Jiang Wenwei , Lin Zhousheng , Lan Xinyue , Zhou Dan , Yao Guangyu
Published: January 2022

Depression contributes to enhanced initiation, development and metastasis of breast cancer. Despite epidemiological studies and experimental data suggest that depression and breast cancer may share a common biological mechanism, the results from these studies remain inconsistent. Here, we fully focus on the underlying biological mechanism behind the adverse effects of depression against breast cancer patients, and highlight the practical therapeutic intervention and improving quality of life. Publicly available datasets deposited in the Gene Expression Omnibus (GEO) were downloaded. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of the differentially expressed genes (DEGs), which were extracted by using R tools, were performed. The protein-protein interaction network of the target DEGs was constructed using Cytoscape software and the hub genes were identified. In our study, we found that genes encoding proinflammatory cytokine, such as IL-1β and TNF, had significantly increased expression in depression. Following chronically stimulated by TNFα and IL-1β (usually for 14-18 days), inflammatory cancer-associated fibroblasts (CAFs) had elevated expression of inflammatory genes. Furthermore, the TNF/TNFRSF1β and LEP/LEPR regulatory axes were proven to be hub pathways of the crosstalk between depression and breast cancer. Our findings demonstrate that inflammatory factors are messengers linking depression and breast cancer, and provided further guidance in clinical medication.
Understanding the Dynamics of Staff Reallocation to Clinical Practice During the First Wave of COVID-19 – a Qualitative Study
Authors: Johansen Rie Laurine Rosenthal , Sørensen Anita , Jespersen Mads Seit , Mikkelsen Kamilla Hesthaven , Emme Christina
Published: January 2022

BackgroundDuring the COVID-19 pandemic, one responsive strategy to ensure hospital staff capacity was reallocation of staff between departments. Unpredicted factors may influence how the strategy is executed. Knowledge of potential moderating factors is essential to improve future staff contingency plans. To understand barriers and promoters of staff realloctation, this study explored the dynamics of reallocating staff from departments with low activity to clinical practice during the first wave of the COVID-19 pandemic at a 530-bed university hospital in the Capital Region of Denmark. MethodsWe used a mixed-methods explanatory design with sequential data collection and analysis. This paper primarily describes the qualitative part of the study, which consisted of six interviews with staff reallocated to clinical practice as part of the staff contingency plan, and seven interviews with leaders of departments that contributed with staff for reallocation. Data was analyzed using inductive content analysis.ResultsThe results showed that the execution of a staff contingency plan during a pandemic is influenced by a complex set of structural, perceptional, social, individual, and psychological moderating factors. Although staff felt obligated and motivated to cover shifts, their actual behavior and experience was influenced by factors such as uncertainty about tasks, family obligations, other work-related tasks, the contingency plan set-up, how the contingency plan, roles, and sense of urgency were interpreted by staff and leaders, and how the leaders prioritized tasks and staff time. Introduction to the unit and tasks, the feeling of being needed, voluntary participation, transparency, collegial sparring, and familiarity with the workplace were factors that promoted a positive experience.ConclusionsThis study identified a variety of complex moderating factors, which should be considered when hospital contingency plans are developed. The study highlights the importance of understanding how reallocated staff and leaders experience and make interpretations and adjustments to a given plan, as this may have great significance for how the contingency plan is put into practice. Future staff contingency plans should take these factors into consideration to make better use of human resources in times of a crisis and to improve staff’s experience with reallocation.
YES kinase controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis
Authors: Jin Yi , Ding Yindi , Richards Mark , Kaakinen Mika , Szymborska Anna , Rosa Andre , Baumann Elisabeth , Giese Wolfgang , Pena Andreia , Nwadozi Emmanuel , Jamalpour Maria , Holstein Katrin , Sáinz-Jaspeado Miguel , Vestweber Dietmar , Welsh Michael , Bernabeu Miguel , Franco Claudio , Eklund Lauri , Gerhardt Holger , Claesson-Welsh Lena
Published: January 2022

Vascular Endothelial (VE)-cadherin in endothelial adherens junctions is an essential component of the vascular barrier, critical for tissue homeostasis and implicated in progression of diseases such as cancer and eye diseases. Inhibitors of SRC cytoplasmic tyrosine kinase have been applied to suppress tyrosine phosphorylation of VE-cadherin and thereby to prevent excessive leakage, edema and high interstitial pressure. We show that the SRC-related YES tyrosine kinase rather than SRC, is localized at endothelial cell (EC) junctions. EC-specific YES deletion suppresses VE-cadherin phosphorylation, and arrests VE-cadherin at EC junctions. This is accompanied by loss of EC collective migration, and exaggerated agonist-induced macromolecular leakage, while extravasation of monocytes is suppressed. Overexpression of Yes causes ectopic VE-cadherin phosphorylation while vascular leakage is unaffected. In contrast, in EC-specific Src-deficient mice, VE-cadherin internalization is maintained and leakage is suppressed. In conclusion, YES-mediated VE-cadherin phosphorylation regulates its constitutive turnover, required for endothelial junction plasticity and vascular integrity.
Functional Outcome in Late Adolescence/ Early Adulthood of Patients With Autism Spectrum Disorder and Its Relationships With Parental Burnout and Depression: Multi-center, Cross-sectional Study
Authors: KUTUK Meryem Ozlem , TUFAN Ali Evren , KILICASLAN Fethiye , VURAL Pinar , GOKCEN Cem , GUNEY Sevay Alsen , KUTUK Bahtım , OZYURT Gonca , INAL Neslihan , MUTLUER Tuba , ACIKALIN Eren Yavuz , OZER Fadime Hande , PAMUK Esma Nur , YESILMESE Seyma Celikcan , KARADAG Mehmet , TOPAL Zehra , BILGINER Cilem , SAHIN Nilfer , BILAC Oznur , KANDEMİR Hasan , ERCAN Eyup Sabri , SOYLEMEZ Tugba Eseroglu , ACIKEL Sadettin Burak , AKSU Gulen Guler , DAG Pelin , TOROS Fevziye , MUTLU Caner , KARDAS Omer , KARDAS Burcu , KIZILDAG Suleyman , DEMIRCI Esra , OZMEN Sevgi , SEVICIN Leyla , KARAGOZ Yuksel Sumeyra , ISIK Umit , AKTEPE Evrim , ALTUN Hatice , YEKTAS Cigdem , TUYSUZ Berna Polat , BUBER Ahmet , CANSIZ Mehmet Akif , OGUTLU Hakan , ERAY Safak , TANER Hande Ayraler , ALTINTAS Ebru , KUTUK Ozgur
Published: January 2022

The aim of this study is to determine functioning of adults with Autism Spectrum Disorders (ASDs) diagnosed in childhood and also depression and burnout levels among their parents. 261 adults with ASDs and their parents were recruited for the study. Both parents completed the Beck Depression and Maslach Burnout Inventories and reported the functioning of their adult offspring with ASDs. Only 5.4 % of our sample reported “good” or “very good” outcome. The most common psychiatric comorbidities were intellectual disabilities and attention-deficit/ hyperactivity disorder. Maternal burnout and depression scores were significantly elevated compared to those of fathers. There is an undeniable urgent need for more research to identify the needs of adults and families suffering from ASD.
Knowledge is Power? Pap Testing Habits of Female OB/GYNs Compared To Other Female Physicians
Authors: Hershkovitz Gal , Ochshorn Yifat , Michaan Nadav , Fiszer Elisheva , Grisaru Dan , Raz Yael
Published: January 2022

Background. To investigate whether knowledge regarding cervical cancer risk factors and Pap testing influence OB/GYN physicians’ compliance to cervical cancer screening and prevention.Methods. Female physicians working in the Tel Aviv Sourasky Medical Center were asked to complete an anonymous questionnaire assessing their knowledge of cervical cancer related factors, Pap testing and compliance with screening guidelines. Reported data was compared between resident and senior OB/GYN physicians and physicians from non-OB/GYN specialties.Results. 42 female OB/GYNs ( residents – 18, seniors- 24) and 80 female physicians of other specialties (“non-OB/GYNs”, residents -48, seniors -32) volunteered to participate in our study, with similar proportions of resident and senior participents between the two groups (p=0.0865). Generally, OB/GYNs were more knowledgable about cervical cancer prevention and risk factors compared to non-OB/GYNs. OB/GYN residents knew less about world health organization (WHO) recommendations for age at last Pap compared to senior OB/GYNs (answered correctly – 50% vs. 83%, respectively, p=0.04). They also knew less about the upper age for vaccine administration (answered correctly – 11% vs 50%, respectively, p=0.01). Even so, the majority of physician recommended Human Papillomavirus vaccination, in all groups compared. A similar proportion of OB/GYNs and non-OB/GYNs had performed a Pap smear in the last 3 years (OB/GYN – 75% non-OB/GYN – 83%, p=0.3). Of note, a higher percentage of residents, both OB/GYNs and non- OBGYNs were vaccinated against Human Papillomavirus compared to their senior counterparts (OB/GYNs -38.89% vs. 4.17%, p=0.013, non-OB/GYNs 50% vs. 12.5%, p=0.0007). Only half of OB/GYNs (residents – 50%, seniors –66.67%, p>0.99) initiated their Pap testing, similar to non-OB/GYNs. Human Papillomavirus vaccination was more prevalent among residents than among seniors, regardless of their specialty (OB/GYNs – 38.89% vs. 4.17%, p=0.013, non OB/GYN – 50% vs. 12.5%, p=0.0007) with a trend toward higher porportions of vaccinated physicians in non-OBGYNs.Conclusion. Female OB/GYNs’ knowledge of the importance of Pap test and their accessibility to Pap smear services, do not improve their compliance for Pap smear performance or Human Papillomavirus vaccination. Residents tend to have better general personal health habits out of their field of specialty.
Gold Nanoclusters Eliminate Obesity Induced by Antipsychotics
Authors: He Meng , Yao Jing , Zhang Zijun , Zhang Ying , Chen Rui , Gu Zhenhua , Huang XuFeng , Deng Chao , Zhou Ruqin , Fan Jun , Zhang Baohua , Xie Yanqian , Gao Guanbin , Sun Taolei
Published: January 2022

Obesity induced by antipsychotics have plagued more than 20 million people worldwide. However, no drug is available to eliminate the obesity induced by antipsychotics. Here we examined the effect and potential mechanisms of a gold nanoclusters (AuNCs) modified by N-isobutyryl-L-cysteine on the obesity induced by olanzapine, the most prescribed but obesogenic antipsychotics, in a rat model. Our results showed that AuNCs completely prevented and reversed the obesity induced by olanzapine and improved glucose metabolism profile in rats. Further mechanism investigations revealed that AuNCs exert its anti-obesity function through inhibition of olanzapine-induced dysfunction of histamine H1 receptor and proopiomelanocortin signaling therefore reducing hyperphagia, and reversing olanzapine-induced inhibition of uncoupling-protein-1 signaling which increases thermogenesis. Together with AuNCs’ good biocompatibility, these findings not only provide AuNCs as a promising nanodrug candidate for treating obesity induced by antipsychotics, but also open an avenue for the potential application of AuNCs-based nanodrugs in treating general obesity