bluuebunny/crossref_metadata_2025 huggingface dataset:
Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation
Authors: Zhang Yingjie , Rai Madhulika , Wang Cheng , Gonzalez Cayetano , Wang Hongyan
Published: March 2016

Prefoldin is a molecular chaperone complex that regulates tubulin function in mitosis. Here, we show that Prefoldin depletion results in disruption of neuroblast polarity, leading to neuroblast overgrowth inDrosophilalarval brains. Interestingly, co-depletion of Prefoldin and Partner of Inscuteable (Pins) leads to the formation of gigantic brains with severe neuroblast overgrowth, despite that Pins depletion alone results in smaller brains with partially disrupted neuroblast polarity. We show that Prefoldin acts synergistically with Pins to regulate asymmetric division of both neuroblasts and Intermediate Neural Progenitors (INPs). Surprisingly, co-depletion of Prefoldin and Pins also induces dedifferentiation of INPs back into neuroblasts, while depletion either Prefoldin or Pins alone is insufficient to do so. Furthermore, knocking down eitherα-tubulinorβ-tubulininpins-mutant background results in INP dedifferentiation back into neuroblasts, leading to the formation of ectopic neuroblasts. Overexpression of α-tubulin suppresses neuroblast overgrowth observed inprefoldin pinsdouble mutant brains. Our data elucidate an unexpected function of Prefoldin and Pins in synergistically suppressing dedifferentiation of INPs back into neural stem cells.
Effects of hydrogen-rich water on depressive-like behavior in mice
Authors: Zhang Yi , Su Wen-Jun , Chen Ying , Wu Teng-Yun , Gong Hong , Shen Xiao-Liang , Wang Yun-Xia , Sun Xue-Jun , Jiang Chun-Lei
Published: March 2016

Emerging evidence suggests that neuroinflammation and oxidative stress may be major contributors to major depressive disorder (MDD). Patients or animal models of depression show significant increase of proinflammatory cytokine interleukin-1β (IL-1β) and oxidative stress biomarkers in the periphery or central nervous system (CNS). Recent studies show that hydrogen selectively reduces cytotoxic oxygen radicals and hydrogen-rich saline potentially suppresses the production of several proinflammatory mediators. Since current depression medications are accompanied by a wide spectrum of side effects, novel preventative or therapeutic measures with fewer side effects might have a promising future. We investigated the effects of drinking hydrogen-rich water on the depressive-like behavior in mice and its underlying mechanisms. Our study show that hydrogen-rich water treatment prevents chronic unpredictable mild stress (CUMS) induced depressive-like behavior. CUMS induced elevation in IL-1β protein levels in the hippocampus and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water. Over-expression of caspase-1 (the IL-1β converting enzyme) and excessive reactive oxygen species (ROS) production in the hippocampus and prefrontal cortex (PFC) was successfully suppressed by hydrogen-rich water treatment. Our data suggest that the beneficial effects of hydrogen-rich water on depressive-like behavior may be mediated by suppression of the inflammasome activation resulting in attenuated protein IL-1β and ROS production.
Visualizing spatial distribution of alectinib in murine brain using quantitative mass spectrometry imaging
Authors: Aikawa Hiroaki , Hayashi Mitsuhiro , Ryu Shoraku , Yamashita Makiko , Ohtsuka Naoto , Nishidate Masanobu , Fujiwara Yasuhiro , Hamada Akinobu
Published: March 2016

In the development of anticancer drugs, drug concentration measurements in the target tissue have been thought to be crucial for predicting drug efficacy and safety. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is commonly used for determination of average drug concentrations; however, complete loss of spatial information in the target tissue occurs. Mass spectrometry imaging (MSI) has been recently applied as an innovative tool for detection of molecular distribution of pharmacological agents in heterogeneous targets. This study examined the intra-brain transitivity of alectinib, a novel anaplastic lymphoma kinase inhibitor, using a combination of matrix-assisted laser desorption ionization–MSI and LC-MS/MS techniques. We first analyzed the pharmacokinetic profiles in FVB mice and then examined the effect of the multidrug resistance protein-1 (MDR1) using Mdr1a/b knockout mice including quantitative distribution of alectinib in the brain. While no differences were observed between the mice for the plasma alectinib concentrations, diffuse alectinib distributions were found in the brain of the Mdr1a/b knockout versus FVB mice. These results indicate the potential for using quantitative MSI for clarifying drug distribution in the brain on a microscopic level, in addition to suggesting a possible use in designing studies for anticancer drug development and translational research.
Ovarian cancer treatment with a tumor-targeting and gene expression-controllable lipoplex
Authors: He Zhi-Yao , Deng Feng , Wei Xia-Wei , Ma Cui-Cui , Luo Min , Zhang Ping , Sang Ya-Xiong , Liang Xiao , Liu Li , Qin Han-Xiao , Shen Ya-Li , Liu Ting , Liu Yan-Tong , Wang Wei , Wen Yan-Jun , Zhao Xia , Zhang Xiao-Ning , Qian Zhi-Yong , Wei Yu-Quan
Published: March 2016

Overexpression of folate receptor alpha (FRα) and high telomerase activity are considered to be the characteristics of ovarian cancers. In this study, we developed FRα-targeted lipoplexes loaded with an hTERT promoter-regulated plasmid that encodes a matrix protein (MP) of the vesicular stomatitis virus, F-LP/pMP(2.5), for application in ovarian cancer treatment. We first characterized the pharmaceutical properties of F-LP/pMP(2.5). The efficient expression of the MP-driven hTERT promoter in SKOV-3 cells was determined after an in-vitro transfection assay, which was significantly increased compared with a non-modified LP/pMP(2.5) group. F-LP/pMP(2.5) treatment significantly inhibited the growth of tumors and extended the survival of mice in a SKOV-3 tumor model compared with other groups. Such an anti-tumor effect was due to the increased expression of MP in tumor tissue, which led to the induction of tumor cell apoptosis, inhibition of tumor cell proliferation and suppression of tumor angiogenesis. Furthermore, a preliminary safety evaluation demonstrated a good safety profile of F-LP/pMP(2.5) as a gene therapy agent. Therefore, FRα-targeted lipoplexes with therapeutic gene expression regulated by an hTERT promoter might be a promising gene therapy agent and a potential translational candidate for the clinical treatment of ovarian cancer.
Variable climatic conditions dominate recent phytoplankton dynamics in Chesapeake Bay
Authors: Harding, Lawrence W. , Mallonee Michael E. , Perry Elgin S. , Miller W. David , Adolf Jason E. , Gallegos Charles L. , Paerl Hans W.
Published: March 2016

Variable climatic conditions strongly influence phytoplankton dynamics in estuaries globally. Our study area is Chesapeake Bay, a highly productive ecosystem providing natural resources, transportation, and recreation for nearly 16 million people inhabiting a 165,000-km2 watershed. Since World War II, nutrient over-enrichment has led to multiple ecosystem impairments caused by increased phytoplankton biomass as chlorophyll-a (chl-a). Doubled nitrogen (N) loadings from 1945–1980 led to increased chl-a, reduced water clarity, and low dissolved oxygen (DO), while decreased N loadings from 1981–2012 suggest modest improvement. The recent 30+ years are characterized by high inter-annual variability of chl-a, coinciding with irregular dry and wet periods, complicating the detection of long-term trends. Here, we synthesize time-series data for historical and recent N loadings (TN, NO2 + NO3), chl-a, floral composition, and net primary productivity (NPP) to distinguish secular changes caused by nutrient over-enrichment from spatio-temporal variability imposed by climatic conditions. Wet years showed higher chl-a, higher diatom abundance, and increased NPP, while dry years showed lower chl-a, lower diatom abundance, and decreased NPP. Our findings support a conceptual model wherein variable climatic conditions dominate recent phytoplankton dynamics against a backdrop of nutrient over-enrichment, emphasizing the need to separate these effects to gauge progress toward improving water quality in estuaries.
VIP: an integrated pipeline for metagenomics of virus identification and discovery
Authors: Li Yang , Wang Hao , Nie Kai , Zhang Chen , Zhang Yi , Wang Ji , Niu Peihua , Ma Xuejun
Published: March 2016

Identification and discovery of viruses using next-generation sequencing technology is a fast-developing area with potential wide application in clinical diagnostics, public health monitoring and novel virus discovery. However, tremendous sequence data from NGS study has posed great challenge both in accuracy and velocity for application of NGS study. Here we describe VIP (“Virus Identification Pipeline”), a one-touch computational pipeline for virus identification and discovery from metagenomic NGS data. VIP performs the following steps to achieve its goal: (i) map and filter out background-related reads, (ii) extensive classification of reads on the basis of nucleotide and remote amino acid homology, (iii) multiple k-mer based de novo assembly and phylogenetic analysis to provide evolutionary insight. We validated the feasibility and veracity of this pipeline with sequencing results of various types of clinical samples and public datasets. VIP has also contributed to timely virus diagnosis (~10 min) in acutely ill patients, demonstrating its potential in the performance of unbiased NGS-based clinical studies with demand of short turnaround time. VIP is released under GPLv3 and is available for free download at: https://github.com/keylabivdc/VIP.
Sub-10 nm feature chromium photomasks for contact lithography patterning of square metal ring arrays
Authors: Park Woongkyu , Rhie Jiyeah , Kim Na Yeon , Hong Seunghun , Kim Dai-Sik
Published: March 2016

Advances in photolithographic processes have allowed semiconductor industries to manufacture smaller and denser chips. As the feature size of integrated circuits becomes smaller, there has been a growing need for a photomask embedded with ever narrower patterns. However, it is challenging for electron beam lithography to obtain <10 nm linewidths with wafer scale uniformity and a necessary speed. Here, we introduce a photolithography-based, cost-effective mask fabrication method based on atomic layer deposition and overhang structures for sacrificial layers. Using this method, we obtained sub-10 nm square ring arrays of side length 50 μm, and periodicity 100 μm on chromium film, on 1 cm by 1 cm quartz substrate. These patterns were then used as a contact-lithography photomask using 365 nm I-line, to generate metal ring arrays on silicon substrate.
Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: evidence from 3,430 patients
Authors: Gu Xiaobin , Sun Shaoqian , Gao Xian-Shu , Xiong Wei , Qin Shangbin , Qi Xin , Ma Mingwei , Li Xiaoying , Zhou Dong , Wang Wen , Yu Hao
Published: March 2016

This study was designed to explore the association between elevated platelet to lymphocyte ratio (PLR) and prognosis of patients with non-small cell lung cancer (NSCLC) by meta-analysis. A total of 11 studies with 3,430 subjects were included and the combined hazard ratio (HR) and 95% confidence intervals (95% CI) were calculated. The data showed that elevated PLR predicted poor overall survival (OS) (HR = 1.42; 95% CI: 1.25–1.61, p < 0.001; I2 = 63.6, Ph = 0.002) and poor disease-free survival (DFS)/progression-free survival (PFS) (HR = 1.19; 95% CI: 1.02–1.4, p = 0.027; I2 = 46.8, Ph = 0.111). Subgroup analysis showed elevated PLR did not predict poor OS in patients included in large sample studies (HR = 1.44; 95% CI: 0.94–2.21, p = 0.098) whereas petients with Caucasian ethnicity (HR = 1.59; 95% CI: 1.27–1.98, p < 0.001) and PLR cut-off value >180 (HR = 1.61; 95% CI: 1.3–1.99, p < 0.001) had enhanced prognostic efficiency for OS. Subgroup analysis also demonstrated that high PLR did not predict poor DFS/PFS in Asian patients. In conclusion, our meta-analysis suggested that elevated PLR was associated with poor OS and DFS/PFS in NSCLC. In addition, high PLR especially predicted poor OS in Caucasians but had no association with poor DFS/PFS in Asians.
Effect of environment on iodine oxidation state and reactivity with aluminum
Authors: Smith Dylan K. , McCollum Jena , Pantoya Michelle L.
Published: March 2016

Iodine oxide is a highly reactive solid oxidizer and with its abundant generation of iodine gas during reaction, this oxidizer also shows great potential as a biocidal agent.
Macroscopic alignment of chromonic liquid crystals using patterned substrates
Authors: Kim Jeong Yeon , Nayani Karthik , Jeong Hyeon Su , Jeon Hwan-Jin , Yoo Hae-Wook , Lee Eun Hyung , Park Jung Ok , Srinivasarao Mohan , Jung Hee-Tae
Published: March 2016

Stable alignment of lyotropic chromonic liquid crystals (LCLCs) is demonstrated, along with an explanation of why such alignment has been difficult.
The structure–function relationship for alumina supported platinum during the formation of ammonia from nitrogen oxide and hydrogen in the presence of oxygen
Authors: Adams Emma Catherine , Merte Lindsay Richard , Hellman Anders , Skoglundh Magnus , Gustafson Johan , Bendixen Eva Charlotte , Gabrielsson Pär , Bertram Florian , Evertsson Jonas , Zhang Chu , Carlson Stefan , Carlsson Per-Anders
Published: March 2016

We study the structure–function relationship of Pt/Al2O3 during the formation of ammonia via in situ analysis techniques.
A versatile sol–gel coating for mixed oxides on nanoporous gold and their application in the water gas shift reaction
Authors: Shi Junjie , Mahr Christoph , Murshed M. Mangir , Zielasek Volkmar , Rosenauer Andreas , Gesing Thorsten M. , Bäumer Marcus , Wittstock Arne
Published: March 2016

Ceria–titania mixed oxides on a structured nanoporous gold support result in highly active and durable catalysts for the water-gas shift reaction.
High methane storage and working capacities in a NbO-type metal–organic framework
Authors: Song Chengling , Liu Huimin , Jiao Jingjing , Bai Dongjie , Zhou Wei , Yildirim Taner , He Yabing
Published: March 2016

By optimization of the pore structure, we achieved an NbO-type MOF exhibiting exceptionally high volumetric methane storage and working capacities of 241 and 190 cm3 (STP) cm−3 at 298 K and 65 bar if the packing loss is not considered.
Boron, nitrogen, and phosphorous ternary doped graphene aerogel with hierarchically porous structures as highly efficient electrocatalysts for oxygen reduction reaction
Authors: Lin Hualin , Chu Lei , Wang Xinjing , Yao Zhaoquan , Liu Fan , Ai Yani , Zhuang Xiaodong , Han Sheng
Published: March 2016

Highly efficient catalysts (mainly 4e−mechanism,Jk: −4.6 mA cm−2) for ORR based on B/N/P ternary-doped graphene aerogels were developed.
Template-directed approach to two-dimensional molybdenum phosphide–carbon nanocomposites with high catalytic activities in the hydrogen evolution reaction
Authors: Yao Zhaoquan , Su Yuezeng , Lu Chenbao , Yang Chongqing , Xu Zhixiao , Zhu Jinhui , Zhuang Xiaodong , Zhang Fan
Published: March 2016

MoP-embedded 2D N-doped porous carbon nanosheets, with excellent electrical conductivity and abundant active sites, achieved high catalytic activity in the HER.
Polyaniline-intercalated MIL-101: selective CO2sorption and supercapacitor properties
Authors: Aliev Sokhrab B. , Samsonenko Denis G. , Maksimovskiy Evgeny A. , Fedorovskaya Ekaterina O. , Sapchenko Sergey A. , Fedin Vladimir P.
Published: March 2016

A novel hybrid material polyaniline@MIL-101 was synthesized and characterized. The obtained compound shows excellent selectivity towards CO2over nitrogen.
Effect of surface chemistry and morphology of gold nanoparticle on the structure and activity of common blood proteins
Authors: Chaudhary Abhishek , Khan Syamantak , Gupta Abhishek , Nandi Chayan Kanti
Published: March 2016

In vitro cell cytotoxicity and conformational study of serum protein with anisotropic gold nanoparticles.
A magnetically recyclable iron oxide-supported copper oxide nanocatalyst (Fe3O4–CuO) for one-pot synthesis of S-aryl dithiocarbamates under solvent-free conditions
Authors: Aryanasab F.
Published: March 2016

A convenient preparation ofS-aryl dithiocarbamates from amine, carbon disulfide and aryl iodide was developed by using the Fe3O4–CuO nanocatalyst under solvent free conditions.
The elasticity of MOFs under mechanical pressure
Authors: Yang Ke , Zhou Guanglin , Xu Quan
Published: March 2016

Nowadays, there is fast growing interest for characterization of mechanical behaviors of MOFs under applied pressures to search for the stable one to resist different mechanical constraints in both processing and complex applications.
Effect of the morphology and phases of WO3 nanocrystals on their photocatalytic efficiency
Authors: Nagy Dávidné , Nagy Dávid , Szilágyi Imre Miklós , Fan Xianfeng
Published: March 2016

Understanding of the effect of the morphology and crystal phase on photocatalytic efficiency and their precise control are still a great challenge in photocatalysis.
Hierarchical mesoporous silicas templated by PE-b-PEO-b-PLA triblock copolymer for fluorescent drug delivery
Authors: Chu Wei-Cheng , Cheng Chien-Chen , Bastakoti Bishnu Prasad , Kuo Shiao-Wei
Published: March 2016

Hierarchical mesoporous silicas for fluorescent drug-delivery molecule templated by PE-b-PEO-b-PLA triblock copolymer.
Effects of sulfur compounds on the hydrogenation and isomerization of 1-hexene over a sulfided CoMo catalyst for hydrodesulfurization
Authors: Tu Chunyan , Li Mingfeng , Li Huifeng , Chu Yang , Liu Feng , Nie Hong , Li Dadong
Published: March 2016

Effects of H2S and organic sulfides on the hydrogenation and isomerization of 1-hexene over a CoMo catalyst were systematically investigated.
Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies
Authors: Dick Markus , Hartmann Rudolf , Weiergräber Oliver H. , Bisterfeld Carolin , Classen Thomas , Schwarten Melanie , Neudecker Philipp , Willbold Dieter , Pietruszka Jörg
Published: March 2016

Understanding the deactivation mechanism of 2-deoxy-d-ribose-5-phosphate aldolase by its natural substrate leads to a single mutant showing complete acetaldehyde resistance.
CO2conversion: the potential of porous-organic polymers (POPs) for catalytic CO2–epoxide insertion
Authors: Alkordi Mohamed H. , Weseliński Łukasz J. , D'Elia Valerio , Barman Samir , Cadiau Amandine , Hedhili Mohamed N. , Cairns Amy J. , AbdulHalim Rasha G. , Basset Jean-Marie , Eddaoudi Mohamed
Published: March 2016

New porous organic polymers have been synthesized and applied as catalysts for cycloaddition of CO2and epoxides under mild conditions with excellent recyclability.
Impact of electrolyte composition on the reactivity of a redox active polymer studied through surface interrogation and ion-sensitive scanning electrochemical microscopy
Authors: Burgess Mark , Hernández-Burgos Kenneth , Cheng Kevin J. , Moore Jeffrey S. , Rodríguez-López Joaquín
Published: March 2016

Elucidating optimal ionic interactions for improving the reactivity of redox polymers.
Photocatalytic oxidation of iron(ii) complexes by dioxygen using 9-mesityl-10-methylacridinium ions
Authors: Tsudaka Takeshi , Ohkubo Kei , Fukuzumi Shunichi
Published: March 2016

Photocatalytic oxidation of iron(ii) complexes by dioxygen occurred using the organic photocatalysts, 9-mesityl-10-methylacridinium ion and 2-phenyl-4-(1-naphthyl) quinolinium ion (QuPh+-NA), in the presence of triflic acid in acetonitrile under visible light irradiation.
Organocatalytic cascade Michael/Michael reaction for the asymmetric synthesis of spirooxindoles containing five contiguous stereocenters
Authors: Zhao Bo-Liang , Du Da-Ming
Published: March 2016

Squaramide-catalyzed cascade Michael/Michael reaction for the asymmetric synthesis of five-membered spirooxindoles containing five contiguous stereocenters is presented.
An unconventional mechanism of hollow nanorod formation: asymmetric Cu diffusion in Au–Cu alloy nanorods during galvanic replacement reaction
Authors: Thota Sravan , Chen Shutang , Zhao Jing
Published: March 2016

Au–Cu alloy nanorods are used as templates in a galvanic replacement reaction to form hollow nanorods through an unconventional mechanism involving the asymmetric diffusion of Cu.
Selective removal of cesium and strontium using porous frameworks from high level nuclear waste
Authors: Aguila Briana , Banerjee Debasis , Nie Zimin , Shin Yongsoon , Ma Shengqian , Thallapally Praveen K.
Published: March 2016

A water stable MOF, MIL-101-SO3H, shows excellent Cs+ and Sr2+ ion exchange properties in aqueous solutions in the presence and absence of competing ions.
One-pot synthesis of mesoporous silica hollow spheres with Mn–N–C integrated into the framework for ethylbenzene oxidation
Authors: Fu Lingling , Zhao Sufang , Chen Yuan , Liu Zhigang
Published: March 2016

Mesoporous silica spheres with Mn–N–C materials integrated into the framework are synthesized via the surfactant (CTAB) template-assisted one-pot approach.
Tuning the electronic and mechanical properties of penta-graphene via hydrogenation and fluorination
Authors: Li Xiaoyin , Zhang Shunhong , Wang Fancy Qian , Guo Yaguang , Liu Jie , Wang Qian
Published: March 2016

First principles calculations reveal that hydrogenation and fluorination can effectively tune the electronic and mechanical properties of penta-graphene, which has recently been proposed as a new allotrope of carbon with novel properties [Zhang et al. Proc. Natl. Acad. Sci. U. S. A., 2015, 112, 2372].
A water-soluble gadolinium metallofullerenol: facile preparation, magnetic properties and magnetic resonance imaging application
Authors: Li Jie , Wang Taishan , Feng Yongqiang , Zhang Ying , Zhen Mingming , Shu Chunying , Jiang Li , Wang Yuqing , Wang Chunru
Published: March 2016

A new water-soluble gadolinium metallofullerenol with an enhanced effective magnetic moment and improved T1-weighted relaxivity and magnetic resonance imaging performance in the liver.
Crystallization kinetics of the phase change material GeSb6Te measured with dynamic transmission electron microscopy
Authors: Winseck M. M. , Cheng H.-Y. , Campbell G. H. , Santala M. K.
Published: March 2016

Crystallization kinetics of a promising phase change material are revealed with advanced photo-emission transmission electron microscopy with nanosecond-scale time resolution.
Tuning the structure and solubility of nanojars by peripheral ligand substitution, leading to unprecedented liquid–liquid extraction of the carbonate ion from water into aliphatic solvents
Authors: Ahmed Basil M. , Calco Brice , Mezei Gellert
Published: March 2016

Carbonate, an anion with large hydration energy, is extracted from water by solvent extraction for the first time, using functionalized nanojars.
Na3Y3(BO3)4: a new noncentrosymmetric borate with an open-framework structure
Authors: Shan Faxian , Kang Lei , Zhang Guochun , Yao Jiyong , Lin Zheshuai , Xia Mingjun , Zhang Xinyuan , Fu Ying , Wu Yicheng
Published: March 2016

A new noncentrosymmetric borate Na3Y3(BO3)4 was synthesized. It features a zeolite-type framework, which is extremely rare in borates.
Electrochemical C–H functionalization and subsequent C–S and C–N bond formation: paired electrosynthesis of 3-amino-2-thiocyanato-α,β-unsaturated carbonyl derivatives mediated by bromide ions
Authors: Kang Li-Shuo , Luo Mi-Hai , Lam Chiu Marco , Hu Li-Ming , Little R. Daniel , Zeng Cheng-Chu
Published: March 2016

An efficient paired electrosynthesis involving C–H functionalization and subsequent C–S and C–N bond formation has been developed.
A highly addressable static droplet array enabling digital control of a single droplet at pico-volume resolution
Authors: Jeong Heon-Ho , Lee Byungjin , Jin Si Hyung , Jeong Seong-Geun , Lee Chang-Soo
Published: March 2016

We present a highly addressable static droplet array (SDA) enabling individual digital manipulation of single droplet using microvalve system.
Computational prediction of virus–human protein–protein interactions using embedding kernelized heterogeneous data
Authors: Nourani Esmaeil , Khunjush Farshad , Durmuş Saliha
Published: March 2016

Pathogenic microorganisms exploit host cellular mechanisms and evade host defense mechanisms through molecular pathogen–host interactions (PHIs).
Performance of optimized noncanonical amino acid mutagenesis systems in the absence of release factor 1
Authors: Zheng Yunan , Lajoie Marc J. , Italia James S. , Chin Melissa A. , Church George M. , Chatterjee Abhishek
Published: March 2016

Unconditional deletion of RF1 in a genomically recoded E. coli enables multisite noncanonical amino acid incorporation by UAG suppression.
Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag
Authors: Griffin Matthew E. , Jensen Elizabeth H. , Mason Daniel E. , Jenkins Courtney L. , Stone Shannon E. , Peters Eric C. , Hsieh-Wilson Linda C.
Published: March 2016

A novel approach utilizing a chemically cleavable Dde-based tag is employed herein to quantitatively label and releaseO-GlcNAcylated proteins for the mass spectrometric identification of previously unknown glycosylation sites.
Ultrafast nonlinear photoresponse of single-wall carbon nanotubes: a broadband degenerate investigation
Authors: Xu Shuo , Wang Fengqiu , Zhu Chunhui , Meng Yafei , Liu Yujie , Liu Wenqing , Tang Jingyi , Liu Kaihui , Hu Guohua , Howe Richard C. T. , Hasan Tawfique , Zhang Rong , Shi Yi , Xu Yongbing
Published: March 2016

The nonlinear optical response of a single-wall carbon nanotube composite is characterized across 600–2400 nm, revealing new spectral signatures of saturable absorption.
A tactile sensor using a conductive graphene-sponge composite
Authors: Chun Sungwoo , Hong Ahyoung , Choi Yeonhoi , Ha Chunho , Park Wanjun
Published: March 2016

A simple method for highly sensitive and flexible graphene-sponge composites and their application toward tactile sensing is reported.
The influence of intramolecular sulfur–lone pair interactions on small-molecule drug design and receptor binding
Authors: Hudson B. M. , Nguyen E. , Tantillo D. J.
Published: March 2016

Sulfur–lone pair interactions are important conformational control elements in sulfur-containing heterocycles that abound in pharmaceuticals, natural products, agrochemicals, polymers and other important classes of organic molecules.
Cyclohexyl-substituted poly(phosphonate)-copolymers with adjustable glass transition temperatures
Authors: Wolf Thomas , Naß Johannes , Wurm Frederik R.
Published: March 2016

2-Cyclohexyl-2-oxo-1,3,2-dioxaphospholane (cyHexPPn), a new monomer for the anionic ring-opening polymerization to poly(ethylene alkyl phosphonate)s is presented.
Nitrogen-doped carbon nanosheets for high-performance liquid as well as solid state supercapacitor cells
Authors: Sahu Vikrant , Grover Sonia , Singh Gurmeet , Sharma Raj Kishore
Published: March 2016

Nitrogen doped carbon nanosheets (NCNS), were synthesized by carbonizing polyaniline nano sheets. Findings suggest that NCNS prepared at 400 °C constitute a high performance supercapacitor with solid as well as liquid electrolytes.
Toxicity assessment of precise engineered gold nanoparticles with different shapes in zebrafish embryos
Authors: Wang Zhenjie , Xie Dan , Liu Hongzhuo , Bao Zhihong , Wang Yongjun
Published: March 2016

The developmental toxicity of gold nanoparticles with different shape in a zebrafish model was investigated and compared.
Palladium(ii) oxide impregnated on magnetite as a catalyst for the synthesis of 4-arylcoumarins via a Heck-arylation/cyclization process
Authors: Pérez Juana M. , Cano Rafael , McGlacken Gerard P. , Ramón Diego J.
Published: March 2016

Heck-arylation/cyclization was achieved using heterogeneous palladium(ii) oxide impregnated on magnetite catalyst (2.5 mol%) with a lower catalyst loading than that reported for similar processes.
Novel solid forms of oxaprozin: cocrystals and an extended release drug–drug salt of salbutamol
Authors: Aitipamula Srinivasulu , Wong Annie B. H. , Chow Pui Shan , Tan Reginald B. H.
Published: March 2016

Novel solid forms of an anti-inflammatory drug, oxaprozin, were identified. A drug–drug salt of oxaprozin with salbutamol was proved promising for development of extended release tablet formulations of salbutamol.
Hemin/G-quadruplex DNAzyme nanowires amplified luminol electrochemiluminescence system and its application in sensing silver ions
Authors: Liu Guangpeng , Yuan Yali , Wang Jianli
Published: March 2016

Herein, a DNA biosensor with a hemin/G-quadruplex DNAzyme amplified luminol electrochemiluminescence (ECL) system was constructed for sensing silver ions (Ag+).
Aryne-induced dearomatized phosphonylation of electron-deficient azaarenes
Authors: Liu Kai , Liu Li-Li , Gu Cheng-Zhi , Dai Bin , He Lin
Published: March 2016

Aryne-induced dearomatic phosphonylation of electron-deficient azaarenes.
Enhanced electrical properties of (Li,Ce) co-doped Sr(Na0.5Bi0.5)Bi4Ti5O18high temperature piezoceramics
Authors: Yao Zhongran , Chu Ruiqing , Xu Zhijun , Hao Jigong , Li Guorong
Published: March 2016

Lead-free piezoelectric ceramics with the formula of Sr1−x(Li,Ce)x/2(Na0.5Bi0.5)Bi4Ti5O18(LCSNBT-x,x= 0.0, 0.1, 0.2, 0.3, 0.4), were prepared by a conventional solid-state reaction method.
Voltammetric determination of 4-chlorophenol using multiwall carbon nanotube/gold nanoparticle nanocomposite modified glassy carbon electrodes
Authors: Wang Ling , Sun Qi , Liu Yang , Lu Zhisong
Published: March 2016

We synthesized gold nanoparticles/carboxyl functionalized multi-walled carbon nanotubes nanocomposites via an in situ reduction method and further explored their potentials in 4-chlorophenol detection.
Multi-modal imaging of HeLa cells using a luminescent ZnS:Mn/NaGdF4:Yb:Er nanocomposite with enhanced upconversion red emission
Authors: Thangaraju Dheivasigamani , Masuda Yuriko , Mohamed Mathar Sahip Ibrahim Khaleelullah , Inami Wataru , Kawata Yoshimasa , Hayakawa Yasuhiro
Published: March 2016

ZnS:Mn/NaGdF4:Yb:Er nanocomposite was synthesized using a single-step hot injection method and then applied in the downconversion and upconversion optical imaging of living HeLa cells.
Use of a novel layered titanoniobate as an anode material for long cycle life sodium ion batteries
Authors: Xie Keyu , Wei Wenfei , Yu Haoran , Deng Manjiao , Ke Shanming , Zeng Xierong , Li Zhihua , Shen Chao , Wang Jian-gan , Wei Bingqing
Published: March 2016

Layered HTi2NbO7 displays excellent cycling stability as the anode in sodium ion batteries.
A pseudo six-component process for the synthesis of tetrahydrodipyrazolo pyridines using an ionic liquid immobilized on a FeNi3nanocatalyst
Authors: Safaei-Ghomi Javad , Sadeghzadeh Reyhaneh , Shahbazi-Alavi Hossein
Published: March 2016

A flexible and highly efficient protocol for the synthesis of tetrahydrodipyrazolo pyridines using FeNi3-ILs MNPs has been developed.
Selective CO adsorbent CuCl/AC prepared using CuCl2 as a precursor by a facile method
Authors: Gao Fei , Wang Yaquan , Wang Xiao , Wang Shuhai
Published: March 2016

CuCl/AC adsorbent with high CO adsorption capacity and selectivity was prepared using CuCl2 as precursor by monolayer dispersion method.
Anhydrous proton conduction in liquid crystals containing benzimidazole moieties
Authors: Tan Shuai , Wei Bingzhuo , Liang Ting , Yang Xiaohui , Wu Yong
Published: March 2016

The mesomorphic benzimidazole compounds exhibit nematic and smectic A phases in which enhanced anhydrous proton conduction is observed.
Surface modification of banana stem fibers via radiation induced grafting of poly(methacrylic acid) as an effective cation exchanger for Hg(ii)
Authors: Salamun N. , Triwahyono S. , Jalil A. A. , Majid Z. A. , Ghazali Z. , Othman N. A. F. , Prasetyoko D.
Published: March 2016

A low cost adsorbent, banana stem fibers (BSFs), was used for modification by grafting with methacrylic acidviathree free radical generation methods.
Aptamer-functionalized P(NIPAM-AA) hydrogel fabricated one-dimensional photonic crystals (1DPCs) for colorimetric sensing
Authors: Xuan Hongyun , Ren Jiaoyu , Zhu Yanxi , Zhao Bo , Ge Liqin
Published: March 2016

A robust means for the visual detection of highly toxic mercury ions (Hg2+) is developed with aptamer-functionalized one-dimensional photonic crystals (1DPCs) produced by spin-coating technology.
From the traditional way of pyrolysis to tunable photoluminescent water soluble carbon nano-onions for cell imaging and selective sensing of glucose
Authors: Tripathi Kumud Malika , Bhati Anshu , Singh Anupriya , Gupta Nidhi Rani , Verma Sankalp , Sarkar Sabyasachi , Sonkar Sumit Kumar
Published: March 2016

Water soluble photoluminescent carbon nano-onions were synthesized from vegetable ghee using traditional pyrolytic approach for imaging cells and selective-immediate detection of glucose via fluorescent “turn-off”/“turn-on” technique.
Study of amorphous Cu–Te–Si thin films showing high thermal stability for application as a cation supply layer in conductive bridge random access memory devices
Authors: Devulder Wouter , Opsomer Karl , Minjauw Matthias M. , Meersschaut Johan , Jurczak Malgorzata , Goux Ludovic , Detavernier Christophe
Published: March 2016

Silicon alloying of Cu0.6Te0.4 results in an amorphous material up to temperatures exceeding 400 °C with a smooth surface morphology, making it compatible with typical device processing temperatures.
Eco-friendly synthesis of ZnO nanopencils in aqueous medium: a study of photocatalytic degradation of methylene blue under direct sunlight
Authors: Kaviya S. , Prasad Edamana
Published: March 2016

Pomegranate peel extract stabilized ZnO nanopencils were shown to exhibit a better photocatalytic degradation of methylene blue under sun light irradiation than commercial ZnO and TiO2 nanoparticles.
Synthesis and electrophosphorescence of novel heteroleptic iridium complexes based on thiazole-containing ligands
Authors: Liu Di , Yao Ruijuan , Fu Min , Li Deli , Zhang Shufen
Published: March 2016

Novel heteroleptic iridium complexes containing aromatic-ring-fused-thiazole in cyclometalating ligands are developed and exhibit a maximum external quantum efficiency of 22.2% in orange phosphorescent organic light-emitting diodes.
Polymerization of conjugated dienes with a homogeneous Ziegler–Natta catalytic system based on a carbon-bridged bis(phenolate) yttrium alkyl complex
Authors: Hong Kan , Liang Zhenhua , Ni Xufeng , Shen Zhiquan
Published: March 2016

1,3-Diene polymerization with some controllable characteristics was carried out and catalyzed by a triisobutylaluminum modified MAO activated complex [(EDBP)Y(CH2SiMe3)(THF)3].
Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones
Authors: Raghav Neera , Jangra Suman , Kumar Ajay , Bhattacharyya Shalmoli , Wadhwa Deepak , Sindhu Jayant
Published: March 2016

A novel series of 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-one derivatives synthesized and structure confirmed by X-ray crystallography have been evaluated as inhibitors to cathepsins B, H and L as well as cell proliferating agents.
One-pot synthesis of various 2-amino-4H-chromene derivatives using a highly active supported ionic liquid catalyst
Authors: Sharma Pankaj , Gupta Monika , Kant Rajni , Gupta Vivek K.
Published: March 2016

Supported ionic liquid phase catalyst was synthesized and applied for the synthesis of chromene derivatives under solvent-free conditions.
Correction: Hemocompatible glutaminase free l-asparaginase from marine Bacillus tequilensis PV9W with anticancer potential modulating p53 expression
Authors: Shakambari Ganeshan , Birendranarayan Anand Kumar , Angelaa Lincy Maria Joseph , Rai Sameer Kumar , Ahmad Quazi Taushif , Ashokkumar Balasubramaniem , Saravanan Matheshwaran , Mahesh Ayyavu , Varalakshmi Perumal
Published: March 2016

Correction for ‘Hemocompatible glutaminase free l-asparaginase from marine Bacillus tequilensis PV9W with anticancer potential modulating p53 expression’ by Ganeshan Shakambari et al., RSC Adv., 2016, 6, 25943–25951.
Crossword puzzles for chemistry education: learning goals beyond vocabulary
Authors: Yuriev Elizabeth , Capuano Ben , Short Jennifer L.
Published: March 2016

Chemistry is a technical scientific discipline strongly underpinned by its own complex and diverse language. To be successful in the problem-solving aspects of chemistry, students must master the language of chemistry, and in particular, the definition of terms and concepts. To assist students in this challenging task, a variety of instructional techniques need to be explored. In this study we have developed crossword puzzles to aid students in mastering chemical terminologyviameaningful learning as opposed to rote memorisation. We have evaluated this tool for its effectiveness in study and revision. Specifically, we asked: (i) are crosswords effective as in-class and out-of-class revision tools? (ii) Is crossword performance (as a measure of the command of scientific vocabulary) predictive of problem-solving ability? The results demonstrated that crossword puzzles improve the ability of students to solve problems and, when used systematically, contribute to increases in learning. The findings are discussed in the context of information processing and meaningful learning.
Flexible-wire shaped all-solid-state supercapacitors based on facile electropolymerization of polythiophene with ultra-high energy density
Authors: Ambade Rohan B. , Ambade Swapnil B. , Salunkhe Rahul R. , Malgras Victor , Jin Sung-Ho , Yamauchi Yusuke , Lee Soo-Hyoung
Published: March 2016

The flexible-wire shaped all-solid-state-supercapacitors developed by electropolymerization of polythiophene show high capacitive performance of 71.84 mF cm−2and ultra-high energy density of 23.11 μW h cm−2using a wide operational potential window of 1.8 V.
Ionic liquid capped carbon dots as a high-performance friction-reducing and antiwear additive for poly(ethylene glycol)
Authors: Wang Baogang , Tang Weiwei , Lu Hongsheng , Huang Zhiyu
Published: March 2016

This work presents ionic liquid capped carbon dots as a high-performance friction-reducing and antiwear additive for poly(ethylene glycol).
Saltwater as the energy source for low-cost, safe rechargeable batteries
Authors: Park Sangmin , SenthilKumar Baskar , Kim Kyoungho , Hwang Soo Min , Kim Youngsik
Published: March 2016

Cheap, familiar saltwater (NaCl solution) was utilized to build low-cost, safe rechargeable batteries for large-scale electrical energy storage applications.
Direct photocatalytic hydrogen evolution from water splitting using nanostructures of hydrate organic small molecule as photocatalysts
Authors: Li Huihui , Jie Liulun , Pan Jiannan , Kang Longtian , Yao Jiannian
Published: March 2016

Direct photocatalytic hydrogen evolution of an organic small-molecule nanostructure was achieved by constructing a heterostructure of hydrate rubrene/ZnP nanosheets.
Molybdate flux growth of idiomorphic Li(Ni1/3Co1/3Mn1/3)O2 single crystals and characterization of their capabilities as cathode materials for lithium-ion batteries
Authors: Kimijima T. , Zettsu N. , Yubuta K. , Hirata K. , Kami K. , Teshima K.
Published: March 2016

Highly dispersed primary Li(Ni1/3Co1/3Mn1/3)O2 crystals, which showed high discharge capacity at a high C-rate, were grown from a Li2MoO4 flux.
Partially PEGylated dendrimer-entrapped gold nanoparticles: a promising nanoplatform for highly efficient DNA and siRNA delivery
Authors: Hou Wenxiu , Wei Ping , Kong Lingdan , Guo Rui , Wang Shige , Shi Xiangyang
Published: March 2016

Partially PEGylated dendrimer-entrapped gold nanoparticles can be used as a promising nanoplatform for highly efficient pDNA and siRNA delivery.
Correction: Epitope imprinting enhanced IMAC (EI-IMAC) for highly selective purification of His-tagged protein
Authors: Li Senwu , Yang Kaiguang , Zhao Baofeng , Li Xiao , Liu Lukuan , Chen Yuanbo , Zhang Lihua , Zhang Yukui
Published: March 2016

Correction for ‘Epitope imprinting enhanced IMAC (EI-IMAC) for highly selective purification of His-tagged protein’ by Senwu Li et al., J. Mater. Chem. B, 2016, 4, 1960–1967.
Partial ligand exchange as a critical approach to the synthesis of transparent ytterbium fluoride–polymer nanocomposite monoliths for gamma ray scintillation
Authors: Jin Yunxia , Kishpaugh David , Liu Chao , Hajagos Tibor Jacob , Chen Qi , Li Lu , Chen Yi , Pei Qibing
Published: March 2016

A partial ligand exchange route to the preparation of transparent polymer nanocomposites with a high nanoparticle loading in bulk size for gamma-ray detection.
Ambipolar organic field-effect transistors based on diketopyrrolopyrrole derivatives containing different π-conjugating spacers
Authors: Lin Gaobo , Qin Yunke , Zhang Jiajia , Guan Ying-Shi , Xu Hai , Xu Wei , Zhu Daoben
Published: March 2016

We report the synthesis and characterization of two ambipolar diketopyrrolopyrrole derivatives containing different π-conjugating spacers.
Joint beamforming and power allocation for secure communication in cognitive radio networks
Authors: Chen Tao , Yuan HuaQiang , Zhao TieZhu , Zhang ZuSheng , Ao Xin
Published: March 2016

In this study, secure communication in cognitive radio networks is investigated. A cooperative jammer is utilised to transmit artificial noise for interfering with the eavesdropper. The authors’ objective is to maximise the available secrecy rate of the secondary user (SU) under the interference power constraint at the primary user and the global transmit power constraint at the transmitters. In that case, beamforming vectors of the SU transmitter and the cooperative jammer, and power allocation between them need to be optimised. However, the optimisation problem is non‐convex and hard to solve. In order to tackle it, two suboptimal algorithms are proposed: complete orthogonal projection and partial orthogonal projection. In these algorithms, the original optimisation problems are first decoupled into two sub‐problems, which deal with the transmit beamforming vectors and power allocation, respectively. Then, the optimal solution is obtained by iteration alternately. Finally, simulation results verify the effectiveness of the proposed algorithms.
Efficient binary search space‐structured VQ encoder applied to a line spectral frequency quantisation in G.729 standard
Authors: Lin Tzu‐Hung , Yeh Cheng‐Yu , Hwang Shaw‐Hwa , Chang Shun‐Chieh
Published: March 2016

This study presents a simple but high performance vector quantisation (VQ) codebook search algorithm for line spectral frequency quantisation in ITU‐T G.729 speech codec, designated as the binary search space‐structured VQ (BSS‐VQ) algorithm. This is done through a combined use of a fast locating technique and lookup tables, such that an input vector, ahead of VQ encoding, is assigned efficiently to a subspace where merely a small number of codeword searches are required to be performed. As a consequence, the computational load is reduced remarkably. A trade‐off can be made easy to meet a user's requirement when performing VQ encoding. It is experimentally validated that a search accuracy is well maintained at 99% approximately for a threshold of quantisation accuracy of 0.99. More importantly, with a full search algorithm as a benchmark for search load comparison, this proposal provides a 85% search load reduction, a figure far beyond 43% in multiple triangular inequality elimination approach, 47% in TIE with dynamic and intersection rules and 59% in quasi‐binary search VQ algorithm.
Rate assignment for multi‐level polarised non‐binary polar codes
Authors: Wu Daolong , Li Ying , Sun Yue
Published: March 2016

In this study, rate assignment for finite length non‐binary polar codes for arbitrary input discrete memoryless channels (AI‐DMC) which can be polarised into multiple levels is discussed. The closed form expression of the block error rate (BLER) of non‐binary polar codes when transmitted over an AI‐DMC is derived first. Then, an element‐wise exchange (EWEX) method is proposed to perform rate assignment to non‐binary polar codes aiming at minimising the BLER. It is also observed that the complexity of the EWEX method grows linearly with the size of the feasible set. The construction of finite length 4‐ary polar codes for a 4‐ary erasure channel which can be polarised into three levels is described in detail. Simulation results show that the codes constructed by the EWEX method have almost the same BLER performance as those constructed by the exhaustive searching method. Moreover, the estimated BLERs keep consistent with the simulation results.
Combined state and multi‐innovation parameter estimation for an input non‐linear state‐space system using the key term separation
Authors: Wang Xuehai , Ding Feng , Hayat Tasawar , Alsaedi Ahmed
Published: March 2016

In this study, the authors study the state and parameter estimation problem for an input non‐linear system consisting of a static non‐linear block and a linear time‐invariant state space subsystem. Using the filtering technique, a filtering based multi‐innovation generalised stochastic gradient (SG) algorithm is proposed for avoiding estimating the redundant parameters based on the key term separation technique. Compared with the multi‐innovation generalised SG algorithm, the proposed algorithm has higher parameter estimation accuracy. Two simulation examples are provided to show that the proposed algorithm works well.
Application of fractional order iterative learning controller for a type of batch bioreactor
Authors: Rezaei Estakhrouiyeh Mohsen , Vali Mohammadali , Gharaveisi Aliakbar
Published: March 2016

In this study, a fractional order iterative learning controller (FOILC) is designed for a non‐linear fractional order bioreactor system. Bioreactors are widely used in horticulture, medical plants, tissue engineering, waste water recycling, biomass production and many other applications. Since fed‐batch systems are repetitive processes and some specific types have fractional dynamics, FOILC algorithm is workable for them. This research shows, via simulations, the benefits of using FOILC along with a robust fractional order PID (FOPID) to attain both robustness and precision tracking for the bio‐reactor system. This leads to better product quality and more flexibility, since the system can learn the new dynamics after a few iterations, in case of plant changes, besides getting better disturbance rejection against repetitive and non‐repetitive disturbances.
Extension and denature temperature of dsDNA molecules at various magnetic forces by using magnetic tweezers
Authors: Chung Yung‐Chiang , Tsai Cheng‐Wei , Lin Shih‐Hao
Published: March 2016

Stretching experiments on lambda‐deoxyribonucleic acid (DNA) were carried out in microfluidic channel using a microscope, micro‐flow pump, and electromagnet. The micro‐flow channel was fabricated by using micro electromechanical technology, and the electromagnet was analyzed by software to simulate the magnetic field distribution. The magnetic field was 248.6 gauss at a current of 0.5 A, and the system could exert 20.4 pN of force on a magnetic bead with diameter of 2.8 μm. When the buffer temperature was 25 °C, the average length of lambda‐DNA molecules was 1.9 μm without magnetic field. In a magnetic field of 248.6 gauss, the extension was 7.2 μm, the total length was 9.1 μm, and the coefficient of elasticity was 2.83 × 10−6N/m. When the buffer temperature was 45 °C, the average length was 4.6 μm without magnetic field. At 45 °C in a magnetic field of 248.6 gauss, the extension was 11.9 μm, the total length was 16.5 μm, and the coefficient of elasticity was 1.71 × 10−6N/m. Besides, the denature temperature of dsDNA decreases with increasing magnetic force, and the temperature difference can be higher than 7 °C. This system can be used to measure the related properties of macromolecules.