bluuebunny/crossref_metadata_2025 huggingface dataset:
The real subsumption of nature and cryopolitics: Temporal fixes in dairy farming in Southern Italy
Authors: Cseke László
Published: May 2024

Water buffaloes have a seasonal cycle of reproduction. Normally they tend to reproduce more when the daylight hours decrease. This seasonal reproduction also means that most of the buffalo calves would be born in autumn and winter in Italy where buffaloes are dairy animals, and milk production would be the highest in these seasons. However, consumer demand for the PDO (Protected designation of origin) mozzarella cheese is the highest in spring and summer. In order to deal with the imbalances between the seasonality of milk production and mozzarella consumption, and the strict regulations of the PDO cheese production, farmers and veterinarians resort to a temporal fix, and they regularly deseasonalise buffalo reproduction. However, there is an obvious discrepancy between the use of this and other fixes (cryotechnologies) generally associated with industrial agriculture, and the idea of traditional and sustainable food production. By engaging with relevant economic geography and political ecology literature, this paper investigates the temporal fixes in dairy farming and agri-food production through an in-depth empirical analysis of deseasonalisation, as a particular form of the real subsumption of nature, and cryopolitics in buffalo mozzarella cheese production in Southern Italy. The work presented in this article is based on multi-sited qualitative field research of buffalo farming and mozzarella cheese production in Campania region. This paper also has wider implications on how socio-ecological fixes shape ‘just-in-time’ animal agriculture and agri-food production.
Dreamtelling: The value of dreaming and sharing dreams in relations: Part I: From collective preoccupations to shared dreaming
Authors: Friedman Robi
Published: May 2024

This article looks at the group approach to shared dreams following previous publications, including Dreams In Group Psychotherapy: Theory and Technique (Neri et al. 2002) and further papers1, and a natural extension to a 2022 publication (Friedman, 2022). One innovative perspective is the notion that it is often a ‘collective preoccupation’ which starts a group’s shared elaboration process (dreaming), which to begin with is transmitted through interpersonal and transpersonal communication to a delegated dreamer. Another new perspective is to view dreaming (mental digestion) as the main process of a revised four step ‘dream cycle’. The dream cycle goes from collective preoccupation, through personal dreaming, then through an inner narrative, followed by a potentially shared relational elaboration. This helps to understand that ‘dreamtelling’ is only the fourth step in the shared process of mental ‘digestion’ of peoples’ excessive threats/excitements.

In Part I I describe the central approach to a shared dream in group analysis as ‘personal responses first’, meaning the predilection of a free-floating discussion of a dream, involving the whole group’s conscious and unconscious mirroring and resonance, while postponing traditional interpretation. Dreams should be understood as both the result and the motor of group processes. Through the joint elaboration of collective preoccupations, dreams that are shared can contribute to the reciprocal healing of relation disorders and dysfunctional relational patterns.

I will describe the four-step ‘dream cycle’, which changes the location of mental digestion. By putting transpersonal and interpersonal communication into action, the individual’s and the group’s mind develops (Köhncke and Mies, (2012)). In the final phase, preoccupying situations and conflictual emotions in dreams are elaborated by free discussion, ‘personal responses first’ which is ‘open communication’ in relational configurations in the ‘society of individuals’ (Elias,1939). This process, which I call ‘dreamtelling’, describes discourse (Schlapobersky, 1993) with potential partners who will ‘(re)dream the dream’, and offer further digestion of the collective preoccupation. A series of clinical vignettes discuss notions such as ‘the location of elaboration’ moves in the relations, e.g. ‘dreaming for others’ and ‘delegation’ as well as the notion of an ‘inner group’ and the unconscious communication between dreamers and listeners.

In Part II, I provide deeper exploration of a clinical example in group-analytic group therapy, describing group work with a dream. The uniqueness of the group-analytic approach to the dream’s contents and its communicative aspect will be stressed. Requests for containment preoccupy relations and participants and should be differentiated during the discourse of ‘dreamtelling’.
In Defense of Liberal Democracy: Exploring Motivations for Protesting against Democratic Backsliding
Authors: Blackington Courtney
Published: May 2024

When incumbent east central European ethnopopulist politicians attack liberal democratic institutions, how does the experience of living through Communism motivate people to protest in defense of liberal democracy? I argue that a critical subset of people in the generation who lived through Communism is extremely active in protests in defense of liberal democratic institutions. A memory of living with authoritarianism and struggling to establish democracy seems to motivate the older generation to actively safeguard these institutions by generating fear of a return to the past. I expect the older generation to be particularly active at protests in defense of democracy when incumbent ethnopopulists engage in democratic backsliding. I explicitly test these hypotheses by analyzing 82 interviews I conducted with people who protested in defense of liberal democratic institutions in nine different Polish towns and cities in 2019, 2021, and 2022. I couple these interviews with data from an original online protester survey and from the European Social Survey.
Differences in imaging biomarkers between patients with intermediate and advanced non-neovascular age-related macular degeneration (AMD) in the University of Colorado AMD registry
Authors: Lisker-Cervantes Andres , Gill Zafar , Gnanaraj Ramya , Rajeswaren Vivian , Mehta Nihaal , Gange Bill , Patnaik Jennifer L , Lynch Anne M , Palestine Alan G , Mathias Marc , Manoharan Niranjan , Mandava Naresh , de Carlo Forest Talisa E
Published: May 2024

Purpose

To quantify and compare the different prevalence rates of specific retinal imaging biomarkers in patients with intermediate AMD (iAMD) and advanced non-neovascular AMD (nnAMD).

Methods

Cross-sectional study of patients with iAMD and advanced nnAMD. Imaging studies were reviewed for qualitative imaging biomarkers. Choroidal thickness measurements were obtained subfoveally and in 1000 um and 2000 um intervals away from the fovea. The Chi-squared test and Fisher's exact test were used to compare rates of imaging biomarkers among the two cohorts. P-value of <0.05 was considered significant.

Results

376 eyes of 197 patients with iAMD and 187 eyes of 97 patients with advanced nnAMD were recruited. There were significantly lower rates of the following imaging biomarkers in the iAMD compared with the advanced nnAMD cohorts: soft drusen (66.0% vs. 84.2%, p = 0.001), calcified drusen (4.3% vs. 40.0%, p < 0.0001), RPD (26.2% vs. 53.3%, p < 0.0001), ORT (0.5% vs. 46.9%, p < 0.0001), RP (1.1% vs. 46.3%, p < 0.0001), pigment migration (53.2% vs. 100%, p < 0.0001), and iRORA (17.9% vs. 80.2%, p < 0.0001). In the iAMD cohort, choroidal thickness was significantly greater at 188 µm (SD: 60) and 194 µm (SD: 69), compared to the advanced nnAMD with measurements of 153 µm (SD: 68), and 161 µm (SD: 76). This difference was statistically significant ( p < 0.0001 and p = 0.0002).

Conclusions

Our results highlight significant differences in imaging biomarkers between both cohorts. Key biomarkers, such as iRORA, RPD, pigment migration, and thinner choroidal thickness, were associated with advanced nnAMD. Identifying these biomarkers early may help target patients who could benefit from new treatments, potentially delaying vision loss.
Exploring the impact of United Nations peacekeeping operations on the external affairs of host states
Authors: Caplan Richard , Gledhill John , Meiske Maline
Published: May 2024

Studies of United Nations (UN) peacekeeping operations (PKOs) typically give scant attention to an important aspect of host states’ development: their external affairs. This article identifies ways in which UN PKOs can shape the external affairs of host states, focusing on UN peacekeeping in the post-Cold War period. We present the findings of a quantitative content analysis of key UN peacekeeping documents to establish which aspects of host state external affairs have been of concern to the UN. We then provide a conceptual framework that maps three areas of external affairs in which PKOs are particularly influential: relationship-building; institution- and diplomatic capacity-building; and the shaping of policy in domains of external affairs. We identify three pathways through which PKOs shape the external affairs of host states: mandated roles, improvised actions, and unintended consequences. Drawing on documentary analysis and original interview data, we illustrate our conceptual framework through an exploration of the impact of peacekeeping on the external affairs of two countries that have hosted large-scale UN-led peacekeeping missions in recent decades: Timor-Leste (East Timor) and Liberia.
On the Embodied Experience of Anti-abortion Laws and Regulations: The Gendered Burden of ‘Abortion Work’
Authors: O’Shaughnessy Aideen Catherine
Published: May 2024

This article explores how abortion laws and regulations are experienced by women and others who may become pregnant at the level of the affected body. It theorises that laws, policies, and regulations which criminalise or obstruct access to abortion shape the embodied subjectivities of gestating individuals in contextually specific ways. This research analyses the experiences of abortion activists in Ireland living under the 8th amendment – the constitutional abortion ban (1983–2018). It proposes the concept of ‘abortion work’ to exemplify the additional forms of reproductive labour imposed on women and people who have historically been forced to anticipate, plan for, and access clandestine abortions inside and outside of Irish borders. It explores how the experience of doing ‘abortion work’ changes the relationship of these individuals to their bodies, which they come to experience ‘out of space-and-time’ and as sites of both intense vulnerability and insurgent agency at the same time.
Acceptance of disability in stroke: A qualitative metasynthesis
Authors: Lim Mervyn JR , Tan Jaclyn , Neo Arturo YY , Ng Brandon CJ , Asano Miho
Published: May 2024

Disability acceptance has been conceptualized as an internalization of oneself as a person experiencing disability and associated with better coping and motivation for rehabilitation. This is particularly pertinent to individuals experiencing stroke because many are initially not fully aware of their stroke-related impairments, which affects the acceptance process. This qualitative metasynthesis aimed to synthesize qualitative findings regarding disability acceptance in stroke and identify barriers and facilitators associated with it. Eighteen studies published from 2003 to 2022, conducted in Asia, Europe, and Australasia, were included in our review. A thematic synthesis was carried out through line-by-line coding and identification of descriptive and analytical themes. Three analytical themes emerged from the analysis: “understanding impairments,” “flexibility and active engagement,” and “disability acceptance as a non-linear process.” Healthcare professionals may facilitate this process by guiding individuals experiencing stroke to recognize that they can manage their limitations and still lead meaningful lives.
Assessment of swallowability and acceptability of scored darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) fixed-dose combination (FDC) tablets in HIV-1–infected children aged ≥6 to <12 years, using matching placebo tablets: A randomized study
Authors: Van Hemelryck Sandy , Van Landuyt Erika , Hufkens Veerle , Vanveggel Simon
Published: May 2024

Background

Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) fixed-dose combination (FDC) was developed as a once-daily, complete antiretroviral (ARV) regimen therapy to address the need for simplified protease inhibitor-based ARV regimens. This study assessed the swallowability and acceptability for long-term use of scored placebo tablets matching the D/C/F/TAF FDC tablets in children living with HIV-1.

Methods

This study (NCT04006704) was a Phase 1, open-label, randomized, single-dose, 2-period, 2-sequence crossover study in children living with HIV-1, aged ≥6 to <12 years and weighing ≥25 to <40 kg, on a stable ARV regimen for ≥3 months. Participants were asked to swallow whole (size, 21 × 11 × 7 mm) and split matching placebo D/C/F/TAF tablets. Swallowability of the matching placebo D/C/F/TAF tablets (primary endpoint) was assessed by observers. Acceptability of taking matching placebo D/C/F/TAF tablets and current ARVs was evaluated by participants using a 3-point questionnaire. Participants rated the acceptability for long-term daily use of the placebo D/C/F/TAF tablets, and observers assessed how easily caregivers could split a scored tablet by hand, using 3-point questionnaires.

Results

Among the 24 participants who enrolled and completed the study, 95.8% (23/24) were able to swallow the whole and split matching placebo D/C/F/TAF tablets after 1 or 2 attempts. Most participants (>70%) rated the acceptability of tablets for long-term daily use as acceptable or good to take. Breaking the tablets was considered easy or OK by 79.2% (19/24) of caregivers.

Conclusion

Scored D/C/F/TAF FDC tablets are swallowable – with whole favoured over split – and considered at least acceptable for long-term daily intake in children living with HIV-1 aged ≥6 to <12 years.

Trial registration

ClinicalTrials.gov Identifier: NCT04006704.
Online self-disclosure: An interdisciplinary literature review of 10 years of research
Authors: Ashuri Tamar , Halperin Ruth
Published: May 2024

The term “self-disclosure” refers to actions by which individuals reveal information about themselves. The interest in such conduct has resurged with the development of networked participatory technologies, which enable creation, dissemination, analysis, and use of large amounts of personal information, thereby increasingly augmenting the effect of online self-disclosure on disclosers and disclosees. This article reviews 309 empirical studies about online self-disclosure published between 2010 and 2020 and aggregates insights thereof into an overarching model describing the ways in which this socio-technical undertaking unfolds. The review shows that online self-disclosure research overwhelmingly focuses on the individual and de-emphasizes structural elements that influence these practices and their outcomes. Based on these findings, we propose a structurational framework centered on the dialectic relationship between individuals and structures involved in self-disclosure and affected by such behaviors. This approach provides a useful tool to address the recent transformations of self-disclosure and its implications in the wake of computer-mediated technological developments.
A rolling bearing fault diagnosis method based on interactive generative feature space oversampling-based autoencoder under imbalanced data
Authors: Huang Fengfei , Zhang Kai , Li Zhixuan , Zheng Qing , Ding Guofu , Zhao Minghang , Zhang Yuehong
Published: May 2024

With the rapid development of railroads and the yearly increase in the scale of operation, the safe operation and maintenance of rail trains have become particularly important. Among them, deep learning-based bearing fault diagnosis methods have attracted more and more attention in rail train operation and maintenance. However, rail trains usually operate normally. Collecting complete fault data for deep learning model training is often difficult. Such scenarios with a large difference between the number of normal data and fault data usually affect the performance of fault diagnosis models. Here, an interactive generative feature space oversampling-based autoencoder (IGFSO-AE) is proposed to realize fault sample generation under imbalanced data. First, the original vibration signal is converted into a semantically stable amplitude–frequency signal by fast Fourier transform and input into the autoencoder; second, the order of the hidden layer space features of the autoencoder is randomly exchanged, and the interactive sample generation learning strategy trains the autoencoder; then, interpolation oversampling is used to interpolate samples in the hidden layer space where the Euclidean distance between samples is large, and is input into the decoder, the generated samples are mixed with the original samples to form a new training set, which is used to train the intelligent fault diagnosis model and output the diagnosis results. Finally, the performance of the proposed method is evaluated using the publicly available bearing dataset and the bogie-bearing fault simulation bench in our lab. The experimental results show that IGFSO-AE can generate diverse samples with incremental information and exhibits robustness and superiority in different imbalanced proportions of data.
Introduction to the Special Issue: Pandemic TV, Then and Now
Authors: Hargraves Hunter
Published: May 2024

This essay serves as the introduction to TVNM’s special issue on “Pandemic TV,” an analysis of the ways in which the COVID-19 pandemic affected principally anglophone television and television-watching in 2020 to 2021 (including television’s response to corresponding events such as the summer 2020 Black Lives Matter uprisings and the fall 2020 U.S. presidential election). The introduction situates various periodizations of the pandemic, framing the dissonant temporalities of the pandemic against television’s traditional approaches to informing, representing, and containing ongoing crises. The essay also introduces the ten articles contained within the special issue, which covers representations of the pandemic, the logics of television present within the videoconferencing applications that came to define communication during the pandemic, and the changing labor of television studies scholars and teachers.
Promotion of Labor Insertion Through the Build Your Professional Career (CCP) Model: A Critical Qualitative Perspective for the Improvement of Professional and Life Projects
Authors: Suárez-Ortega Magdalena , Zapata-Sepúlveda Pamela , García-Ripa María Inés , Romero-García Carolina
Published: May 2024

Advances in the development of the Reinvent Yourself project are presented, the purpose of which is to validate the CCP (Build your Professional Career) model for job improvement in the Autonomous Community of Andalusia in southern Spain. The CCP model is an integrative and inclusive proposal within the framework of professional career development. Through training in transversal competencies and career management, the CCP model aims to favor the processes of labor reintegration by responding to the needs that people present from a conscious and critical perspective. In this process, a qualitative perspective is prioritized because of what the model contributes to a person’s reflexivity, awareness, and self-determination. This article reflects on the potential of the model and of the critical qualitative methodology in processes of constructing identity and a professional career. The potential of the model and of the critical qualitative methodology to facilitate the processes of building a professional career is evidenced. This methodology and the tools used allow a greater social and personal impact in terms of equality and social justice.
Identification of Breast Cancer Subtypes Based on Endoplasmic Reticulum Stress-Related Genes and Analysis of Prognosis and Immune Microenvironment in Breast Cancer Patients
Authors: Yi Chen , Yang Jun , Zhang Ting , Qin Liu , Chen Dongjuan
Published: May 2024

Introduction: Endoplasmic reticulum stress (ERS) was a response to the accumulation of unfolded proteins and plays a crucial role in the development of tumors, including processes such as tumor cell invasion, metastasis, and immune evasion. However, the specific regulatory mechanisms of ERS in breast cancer (BC) remain unclear. Methods: In this study, we analyzed RNA sequencing data from The Cancer Genome Atlas (TCGA) for breast cancer and identified 8 core genes associated with ERS: ELOVL2, IFNG, MAP2K6, MZB1, PCSK6, PCSK9, IGF2BP1, and POP1. We evaluated their individual expression, independent diagnostic, and prognostic values in breast cancer patients. A multifactorial Cox analysis established a risk prognostic model, validated with an external dataset. Additionally, we conducted a comprehensive assessment of immune infiltration and drug sensitivity for these genes. Results: The results indicate that these eight core genes play a crucial role in regulating the immune microenvironment of breast cancer (BRCA) patients. Meanwhile, an independent diagnostic model based on the expression of these eight genes shows limited independent diagnostic value, and its independent prognostic value is unsatisfactory, with the time ROC AUC values generally below 0.5. According to the results of logistic regression neural networks and risk prognosis models, when these eight genes interact synergistically, they can serve as excellent biomarkers for the diagnosis and prognosis of breast cancer patients. Furthermore, the research findings have been confirmed through qPCR experiments and validation. Conclusion: In conclusion, we explored the mechanisms of ERS in BRCA patients and identified 8 outstanding biomolecular diagnostic markers and prognostic indicators. The research results were double-validated using the GEO database and qPCR.
Utility of Toe-Brachial Index
Authors: Del Valle William
Published: May 2024

Introduction:

The toe-brachial index is typically an adjunctive examination to the ankle-brachial index, which has long been the primary physiologic modality for diagnosing peripheral arterial disease. The goal of this project was to determine toe-brachial index reliability, particularly with patients with diabetes.

Methods:

We compared duplex ultrasound to the ankle-brachial index and toe-brachial index on 100 patients (200 legs) with suspected symptomatic peripheral arterial disease. Duplex ultrasound stenosis in the femoral/popliteal/infrapopliteal arteries was at least a doubling of velocity between adjacent segments. A blunted systolic Doppler waveform was consistent with proximal occlusive disease. Normal physiologic ranges were arbitrarily set as ankle-brachial index 1.2 to 0.9 and toe-brachial index 0.9 to 0.5. We calculated overall sensitivity/specificity values by averaging.

Results:

Both physiologic modalities had overall low sensitivity (ankle-brachial index 62%, toe-brachial index 56%). In diabetics, ankle-brachial index sensitivity was 61% and toe-brachial index sensitivity was 57%. Sensitivity improved in the presence of inflow disease (ankle-brachial index 78%, toe-brachial index 63%). Both modalities had good overall specificity (ankle-brachial index 96%, toe-brachial index 86%). In patients with diabetes, the ankle-brachial index specificity was 94% and toe-brachial index specificity was 79%. Both physiologic modalities had identical accuracy (0.43) in comparison to duplex ultrasound.

Conclusion:

Routine toe-brachial index in conjunction with the ankle-brachial index may not be clinically productive.
Single-Port Robotic Trans-Subxiphoid Surgery for Anterior Mediastinal Disease: A Pilot Trial
Authors: Cheng Chuan , Tagkalos Evangelos , Ng Chong Beng , Hsu Ya-Chun , Huang Yu Ya , Wu Ching Feng , Chao Yin-Kai
Published: May 2024

Objective:

In recent years, there has been an increasing focus on minimally invasive mediastinal surgery using a trans-subxiphoid single-port thoracoscopic approach. Despite its potential advantages, the widespread adoption of this method has been hindered by the intricate surgical maneuvers required within the confined retrosternal space. Robotic surgery offers the potential to overcome the limitations inherent in the thoracoscopic technique.

Methods:

This was a clinical trial (NCT05455840) to evaluate the feasibility and safety of utilizing the da Vinci® SP system (Intuitive Surgical, Sunnyvale, CA, USA) for trans-subxiphoid single-port surgery in patients with anterior mediastinal disease. The primary endpoints encompassed conversion rates and the secondary endpoints included the occurrence of perioperative complications.

Results:

Between August 2022 and April 2023, a total of 15 patients (7 men and 8 women; median age = 56 years, interquartile range [IQR]: 49 to 65 years) underwent trans-subxiphoid robotic surgery using da Vinci SP platform for maximal thymectomy ( n = 2) or removal of anterior mediastinal masses ( n = 13). All surgical procedures were carried out with success, with no need for conversion to open surgery or the creation of additional ports. The median docking time was 2 min (IQR: 1 to 4 min), while the console time had a median of 152 min (IQR: 95 to 191 min). There were no postoperative complications and patients experienced a median postoperative hospital stay of 2 days with no unplanned 30-day readmission.

Conclusions:

This study shows that trans-subxiphoid single-port robotic surgery employing the da Vinci SP system in patients with anterior mediastinal disease is clinically viable with acceptable safety and short-term outcomes.
Infliximab monitoring in Crohn’s disease: a neural network approach for evaluating disease activity and immunogenicity
Authors: Gomes Luis Eduardo Miani , Genaro Livia Moreira , Castro Marina Moreira de , Ricci Renato Lazarin , Pascoal Livia Bitencourt , Silva Filipe Botto Crispim , Bonfitto Pedro Henrique Leite , Camargo Michel Gardere , Corona Ligiana Pires , Ayrizono Maria de Lourdes Setsuko , Azevedo Anibal Tavares de , Leal Raquel Franco
Published: May 2024

Background:

The treatment for Crohn’s disease (CD) has increasingly required the use of biological agents. Safe and affordable tests have led to the active implementation of therapeutic drug monitoring (TDM) in clinical practice, which, although not yet widely available across all health services, has been proven effective.

Objective:

To analyze serum infliximab (IFX) and antidrug antibody (ADA) levels in CD patients, compare two tests, as well as construct a prediction of neural network using a combination of clinical, epidemiological, and laboratory variables.

Design:

Cross-sectional observational study.

Method:

A cross-sectional observational study was conducted on 75 CD patients in the maintenance phase of IFX treatment. The participants were allocated into two groups: CD in activity (CDA) and in remission (CDR). Disease activity was defined by endoscopic or radiological criteria. Serum IFX levels were measured by enzyme-linked immunosorbent assay (ELISA) and rapid lateral flow assay; ADA levels were measured by ELISA. A nonparametric test was used for statistical analysis; p value of ⩽0.05 was considered significant. Differences between ELISA and rapid lateral flow results within the measurement range were assessed by the Wilcoxon test, Passing–Bablok regression, and Bland–Altman method. Prediction models were created using four neural network sets. Neural networks and performance receiver operating characteristic curves were created using the Keras package in Python software.

Results:

Most participants exhibited supratherapeutic IFX levels (>7 mg/mL). Both tests showed no difference in IFX levels between the CDA and CDR groups ( p > 0.05). The use of immunosuppressive therapy did not affect IFX levels ( p > 0.05). Only 14.66% of patients had ADA levels >5 AU/mL, and all ADA-positive participants exhibited subtherapeutic IFX levels in both tests. The median results of both tests showed significant differences and moderate agreement ( r = −0.6758, p < 0.001). Of the four neural networks developed, two showed excellent performance, with area under the curve (AUCs) of 82–92% and 100%.

Conclusion:

Most participants exhibited supratherapeutic IFX levels, with no significant serum level difference between the groups. There was moderate agreement between tests. Two neural network sets showed disease activity and the presence of ADA, noninvasively determined in patients using IFX by presenting an AUC of >80%.
Efficiency of bladder-sparing strategies for bladder cancer: an umbrella review
Authors: Li Deng-xiong , Yu Qing-xin , Wu Rui-cheng , Wang Jie , Feng De-chao , Deng Shi
Published: May 2024

Bladder preservation (BP) has emerged as a clinical alternative to radical cystectomy (RC) for alleviating the substantial physical and psychological burden imposed on localized bladder cancer patients. Nevertheless, disparities persist in the comparative evaluations of BP and RC. We aimed to address the disparities between BP and RC. An umbrella review and meta-analysis were conducted to explore these disparities. We extracted data from meta-analyses and randomized controlled trials (RCTs) selected after searching PubMed, Embase, Web of Science, and the Cochrane Database of Systematic Reviews. Review Manager 5.4.0 and R x64 4.1.3 were used to evaluate the collected data. Our study included 11 meta-analyses and 3 RCTs. In terms of progression-free survival, all the meta-analyses reported that patients with localized bladder cancer who underwent BP exhibited outcomes comparable to those who underwent RC. Meta-analyses regarding the outcomes of cancer-specific survival (CSS) and overall survival (OS) are controversial. To solve these issues, we conducted a pooled analysis of CSS data, which supported the similarity of CSS between BP and RC with no significant heterogeneity [odds ratio (OR): 1.2; 95% confidence interval (CI): 0.71–2.02; I2 = 26%]. Similarly, the pooled OS results extracted from three RCTs indicated the comparability of OS between BP and RC with no significant heterogeneity (OR: 1.12; 95% CI: 0.41–3.07; I2 = 33%). A combination of umbrella review and meta-analysis results suggested that BP had survival rates comparable to those of RC. We suggest that BP may be a more eligible therapy than RC for patients with localized muscle-invasive bladder cancer. This conclusion warrants further validation through randomized controlled trials.
Addressing Barriers to Timely Orthopaedic Follow-up for Foot and Ankle Fractures After Emergency Department Visits
Authors: Rana Parimal , Brennan Jane , Johnson Andrea , Donegan Caroline , Gelfand Jake , Spirt Adrienne , Keblish David , Turcotte Justin , Friedmann Elizabeth
Published: May 2024

Introduction. Foot and ankle fractures present common challenges in emergency departments, warranting careful follow-up protocols for optimal patient outcomes. This study investigates the predictors of orthopaedic follow-up for these injuries after an emergency department (ED) visit. Methods. A retrospective observational study of 1450 patients seen in the ED with foot or ankle fractures from July 2015 to February 2023 was conducted. All included patients were discharged with instructions to follow-up with an orthopaedic provider. Demographic data, fracture details, and follow-up patterns were extracted from medical records. Social vulnerability was assessed using the Centers for Disease Control (CDC) Social Vulnerability Index. Univariate and multivariate analyses were performed to identify predictors of follow-up. A subgroup analysis comparing patients who followed up >7 days from ED presentation (ie, delayed follow-up) to those who followed up within 7 days of presentation was then performed. Statistical significance was assessed at P < .05. Results. Overall, 974/1450 (67.2%) patients followed up with orthopaedics at an average time of 4.16 days. After risk adjustment, Medicaid coverage (odds ratio [OR] = 0.56, P = .018), increased overall social vulnerability (OR = 0.83, P = .032), and increased vulnerability across the dimensions of socioeconomic status (P = .002), household characteristics (P = .034), racial and ethnic minority status (P = .007), and household type and transportation (P = .032) were all associated with lower odds of follow-up. Phalangeal fractures were also associated with decreased odds of follow-up (OR = 0.039, P < .001), whereas ankle fractures were more likely to follow-up (OR = 1.52, P = .002). In the subgroup analysis, patients of older age (P = .008), non-white race (P = .024), motor vehicle accident (MVA) (P = .027) or non-private insurance (P = .027), those experiencing phalangeal fractures (P = .015), and those seen by an orthopaedic provider in the ED (P = .006) were more likely to present with delayed follow-up. Conclusion. Patients with increased social vulnerability and Medicaid insurance are less likely to seek follow-up care after presentation to the ED with foot and ankle fractures.
Hyaluronic Acid and Large Extracellular Vesicles (EVs) in Synovial Fluid and Plasma of Patients With End-Stage Arthritis: Positive Association of EVs to Joint Pain
Authors: Mustonen Anne-Mari , Capra Janne , Oikari Sanna , Säisänen Laura , Karttunen Lauri , Julkunen Petro , Lehenkari Petri , Joukainen Antti , Jaroma Antti , Paakkonen Tommi , Kääriäinen Tommi , Kröger Heikki , Nieminen Petteri
Published: May 2024

Objective

Hyaluronic acid (HA) in synovial fluid (SF) contributes to boundary lubrication with altered levels in osteoarthritis (OA) and rheumatoid arthritis (RA). SF extracellular vesicles (EVs) may participate in arthritis by affecting inflammation and cartilage degradation. It remains unknown whether HA and EVs display joint-specific alterations in arthritic SFs.

Design

We investigated the numbers and characteristics of HA-particles and large EVs in SF from knees and shoulders of 8 OA and 8 RA patients and 8 trauma controls, and in plasma from 10 healthy controls and 11 knee OA patients. The plasma and SF HA concentrations were determined with a sandwich-type enzyme-linked sorbent assay, and EVs and HA-particles were characterized from plasma and unprocessed and centrifuged SFs with confocal microscopy. The data were compared according to diagnosis, location, and preanalytical processing.

Results

The main findings were: (1) OA and RA SFs can be distinguished from trauma joints based on the distinctive profiles of HA-particles and large EVs, (2) there are differences in the SF HA and EV characteristics between shoulder and knee joints that could reflect their dissimilar mobility, weight-bearing, and shock absorption properties, (3) EV counts in SF and plasma can positively associate with pain parameters independent of age and body adiposity, and (4) low-speed centrifugation causes alterations in the features of HA-particles and EVs, complicating their examination in the original state.

Conclusions

Arthritis and anatomical location can affect the characteristics of HA-particles and large EVs that may have potential as biomarkers and effectors in joint degradation and pain.
Loneliness and Other Factors Associated with Physical Activity in Older Adults with Diabetes: A Cross-Sectional Study
Authors: Cho Emma
Published: May 2024

The purpose of this study was to examine the association of physical activity with socioeconomic conditions, demographic factors, depression, and loneliness among older adults with diabetes in the United States. Using data from Wave 3 of the National Social Life, Health, and Aging Project (NSHAP), we found that male respondents, those with incomes greater than $100,000, and those with less depression were more likely to be physically active among older adults with diabetes. Education level and loneliness were not significant factors influencing physical activity among older adults with diabetes. This suggests that changing gender-based social norms and increasing awareness of the need for physical activity should be considered when designing physical activity interventions for older adults with diabetes and highlights the need for programs to reduce disparities in physical activity opportunities among low-income populations. It also suggests the need to further integrate programs to promote mental health, such as depression, into physical activity interventions.
Migration and Multiple Forms of Asian Indian American Christian Belonging
Authors: George Geomon , Stephen Kamalesh
Published: May 2024

Migration is changing and revitalizing the religious and cultural landscape of the United States. This article explores the theme of migration and belonging within the Asian Indian Christian community. Building upon this theme, the article draws attention to the myth of Asian Indians being a “model community” and experiences of foreignness of belonging. This article also argues that despite the perception of economic mobility, Asian Indians face discrimination and a sense of foreignness of belonging. It is suggested that autobiographical theology becomes a powerful tool to understand family, church, and community.
Psychometric Analyses of a Food Literacy Behaviors Questionnaire for Adults With Type 2 Diabetes Mellitus
Authors: Ludwig Sarah O. , Cater Melissa W. , Tuuri Georgianna
Published: May 2024

Purpose:

The purpose of the study was to develop and validate a food literacy instrument specific to individuals with type 2 diabetes mellitus (T2DM).

Methods:

Twelve T2DM-specific, food literacy-related statements underwent content validity and face validity testing, and exploratory factor analysis (EFA) was conducted (phase 1). The 6 statements remaining after EFA testing were added to an existing food literacy questionnaire called the Eating and Food Literacy Behaviors Questionnaire (EFLBQ). Confirmatory factor analysis (CFA) examined the EFLBQ plus the T2DM-specific statements, and the instrument was called the Eating and Food Literacy Questionnaire for Diabetics (EFLBQ-D; phase 2). Both EFA and CFA were administered by third-party provider Centiment via Qualtrics to adults with T2DM residing in the 13 United States Department of Agriculture Southern region states. Reliability was assessed via point estimate reliability testing.

Results:

The EFA items clustered into 2 factors each with 3 statements: (1) carbohydrate counting and nutrition label reading and (2) healthy food preparation methods. The CFA indicated that the EFLBQ-D had good fit and that the factors had good reliability. The EFLBQ’s integrity was maintained with its items loading on the respective constructs.

Conclusions:

The EFLBQ-D appears to be a valid, reliable instrument for use by researchers and professionals to better understand food behaviors and food literacy skills of those with T2DM. This is an important tool to help individualize medical nutrition therapy, improving patient care in this population.
The Progression of Technology Integration in the Music Classroom to Support Student Engagement: Part I-Using Google Keep
Authors: Brown Amy
Published: May 2024

Pre-pandemic, technology integration into music lessons was helpful but not a necessity for effectively teaching elementary music. Those who believed technology integration was important for student engagement, as well as those comfortable with their technological skills, were experimenting with tools on an interactive board or through a website within a whole group. This article presents solutions to the challenges of integrating technology in the general music classroom setting. Specifically, this article explains a music activity using Google Keep, a note and list application not typically used to teach music, and the steps for integrating technology and providing feedback using student discourse.
Bullous Lung Disease due to Pulmonary Tuberculosis: A Rare Case Complicated With Tension Pneumothorax and Bronchopleural Fistula
Authors: Morán-Mariños Cristian , Vidal-Ruiz María , Llanos-Tejada Felix , Chavez-Huamani Antonella , Salas-Lopez Juan , Villanueva-Villegas Renzo , Casanova-Mendoza Renato
Published: May 2024

Bullous lung disease caused by tuberculosis is rare, and complications have a poor prognosis with uncertain pathophysiologic mechanisms. We describe a 29-year-old male patient who was admitted to the emergency department due to bilateral tension pneumothorax, which was complicated by bronchopleural fistula. This was managed with the placement of chest tubes, continuity of anti-TB drug treatment, and Heimlich valve placement.
Serial Cervical Length Measurement for Determining the Risk of Preterm Labor: A Prospective Study
Authors: Hurzad Maryam , Manteghi Golshan , Tofighi Shabnam , Molaei Behnaz
Published: May 2024

Objective:

This study aimed to evaluate whether serial evaluations of cervical length (CL) have the potential to determine preterm labor in women with threatening preterm labor (TPL).

Materials and Methods:

This prospective study included pregnant women at 24 to 37 weeks of gestation referred to our institute because of TPL. Cervical length was measured at three successive time points using transvaginal sonography (upon admission, one-, and two-weeks post-admission). Data were analyzed using both parametric and non-parametric statistics.

Results:

The mean age of the 126 patients included was 25.60 ± 6.48 years, with age ranging from 14 to 42 years. The mean pregnancy age, at the time of the sonogram, was 33.54 ± 2.78 weeks. The initial CL had an area under the receiver operating characteristic curve (AUROC) of 0.854. The CLs measured one and two weeks later had AUROCs of 0.868 and 0.870, respectively. Based on these data, the cut-off points of 28.5 and 27.5 mm were identified for the initial and subsequent two-week CL measurements, respectively, capable of predicting preterm delivery. If the CL measured at initial admission was >28.5 mm, the likelihood of timely delivery was 92.22%. However, if the CL measured at initial admission was <28.5 mm, the chance of premature preterm delivery increased by 2.3 times. Patients with a CL <27.5 mm in the second week were 18.75% more likely to have a preterm delivery. If the CL was >27.5 mm, the probability of timely delivery was 89.7%.

Conclusion:

In this cohort of women, serially measured CLs taken during transvaginal sonography demonstrated promise as a method for indicating the possible risk of preterm delivery. Thus, measured CL may be a useful diagnostic component for prenatal care, as well as for classifying the risk of preterm delivery. Nevertheless, further studies are required to confirm the effectiveness and safety of these sonographic measures in larger and more diverse patient cohorts.
Inducible CXCL12/CXCR4–dependent extramedullary hematopoietic niches in the adrenal gland
Authors: Schyrr Frédérica , Alonso-Calleja Alejandro , Vijaykumar Anjali , Sordet-Dessimoz Jessica , Gebhard Sandra , Sarkis Rita , Bataclan Charles , Ferreira Lopes Silvia , Oggier Aurélien , de Leval Laurence , Nombela-Arrieta César , Naveiras Olaia
Published: May 2024

Adult hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow (BM) hematopoietic niche, which regulates HSPC quiescence, self-renewal, and commitment in a demand-adapted manner. Although the complex BM niche is responsible for adult hematopoiesis, evidence exists for simpler, albeit functional and more accessible, extramedullary hematopoietic niches. Inspired by the anecdotal description of retroperitoneal hematopoietic masses occurring at higher frequency upon hormonal dysregulation within the adrenal gland, we hypothesized that the adult adrenal gland could be induced into a hematopoietic-supportive environment in a systematic manner, thus revealing mechanisms underlying de novo niche formation in the adult. Here, we show that upon splenectomy and hormonal stimulation, the adult adrenal gland of mice can be induced to recruit and host functional HSPCs, capable of serial transplantation, and that this phenomenon is associated with de novo formation of platelet-derived growth factor receptor α/leptin receptor (PDGFRα+/LEPR+/–)–expressing stromal nodules. We further show in CXCL12–green fluorescent protein reporter mice that adrenal glands contain a stromal population reminiscent of the CXCL12-abundant reticular cells, which compose the BM HSPC niche. Mechanistically, HSPC homing to hormonally induced adrenal glands was found dependent on the CXCR4–CXCL12 axis. Mirroring our findings in mice, we found reticular CXCL12+ cells coexpressing master niche regulator FOXC1 in primary samples from human adrenal myelolipomas, a benign tumor composed of adipose and hematopoietic tissue. Our findings reignite long-standing questions regarding hormonal regulation of hematopoiesis and provide a novel model to facilitate the study of adult-specific inducible hematopoietic niches, which may pave the way to therapeutic applications.
Shed teeth from Portezuelo formation at Sierra del Portezuelo reveal a higher diversity of predator theropods during Turonian-Coniacian times in northern Patagonia
Authors: Meso Jorge Gustavo , Gianechini Federico , Gomez Kevin Leonel , Muci Luciana , Baiano Mattia Antonio , Pol Diego , Kaluza Jonatan , Garrido Alberto , Pittman Michael
Published: May 2024

The study of thirty-two shed crowns from the Portezuelo Formation (middle Turonian-late Coniacian) at the Sierra del Portezuelo locality, reveals six distinct tooth morphotypes identified through cladistic, discriminant, and cluster analyses. Two morphotypes were identified as belonging to Megaraptoridae, three to Abelisauridae, one to Abelisauroidea, and one to Alvarezsauridae. Additionally, two of the morphotypes exhibit a combination of dental features typically found in megaraptorid and abelisauridtheropods. These results suggest a greater diversity of theropods in the original ecosystem than previously thought, including the presence of a second morphotype of megaraptorid and alvarezsaurid previously undocumented in this formation. Furthermore, the existence of Morphotype 6 indicates the potential coexistence of medium-sized abelisauroids alongside larger abelisaurids in the same ecosystem. These findings underscore the importance of future expeditions to the Sierra del Portezuelo locality to further our understanding of these previously unknown theropod species.
Intraspecific and interspecific variations in the synonymous codon usage in mitochondrial genomes of 8 pleurotus strains
Authors: Gao Wei , Chen Xiaodie , He Jing , Sha Ajia , Luo Yingyong , Xiao Wenqi , Xiong Zhuang , Li Qiang
Published: May 2024

In this study, we investigated the codon bias of twelve mitochondrial core protein coding genes (PCGs) in eight Pleurotus strains, two of which are from the same species. The results revealed that the codons of all Pleurotus strains had a preference for ending in A/T. Furthermore, the correlation between codon base compositions and codon adaptation index (CAI), codon bias index (CBI) and frequency of optimal codons (FOP) indices was also detected, implying the influence of base composition on codon bias. The two P. ostreatus species were found to have differences in various base bias indicators. The average effective number of codons (ENC) of mitochondrial core PCGs of Pleurotus was found to be less than 35, indicating strong codon preference of mitochondrial core PCGs of Pleurotus. The neutrality plot analysis and PR2-Bias plot analysis further suggested that natural selection plays an important role in Pleurotus codon bias. Additionally, six to ten optimal codons (ΔRSCU > 0.08 and RSCU > 1) were identified in eight Pleurotus strains, with UGU and ACU being the most widely used optimal codons in Pleurotus. Finally, based on the combined mitochondrial sequence and RSCU value, the genetic relationship between different Pleurotus strains was deduced, showing large variations between them. This research has improved our understanding of synonymous codon usage characteristics and evolution of this important fungal group.