bluuebunny/crossref_metadata_2025 huggingface dataset:
Expanding the Knowledge Related to Flavors and Fragrances by Means of Three-Dimensional Preparative Gas Chromatography and Molecular Spectroscopy
Authors: De Grazia Gemma , Cucinotta Lorenzo , Rotondo Archimede , Donato Paola , Mondello Luigi , Sciarrone Danilo
Published: August 2022

As universally known, gas chromatography (GC) coupled with mass spectrometry (MS) allows us to acquire spectra that can be searched in specific databases to attain qualitative information on a peak of interest. When not present in databases, structure elucidation is required before including a new component in a library: from that moment, scientists all around the world will be able to identify the new molecule with analytical confidence after GC-MS analysis. Conversely, if data are not shared in commercial databases, even if a molecule is studied and elucidated, it appears to be unknown or only identifiable on the basis of third-party data taken from the literature, which is a serious limitation. The present paper deals with a case that confirms this assumption. A component of Myrtus communis L. volatile fraction was tentatively identified based on literature data. Despite this, reliable identification could not be achieved due to the lack of a corresponding spectrum in commercial MS databases. Afterwards, the target component was isolated in a reasonable quantity and with a high degree of purity for downstream characterization by spectroscopic techniques. For this purpose, preparative (prep) GC may appear insufficient for the isolation of volatile components from highly complex samples. In this study, a prep-MDGC system was implemented for the isolation of the compound of interest from myrtle oil, consisting of three wide-bore columns of different selectivity coupled by means of Deans switch transfer devices. Based on the NMR and GC-FTIR data acquired, the unknown compound was identified as 2,2,5,5,7,7-hexamethyl-3,7-dihydro-1-benzofuran-4,6(2H,5H)-dione. Noticeably, this is a known molecule, yet its mass spectrum had never been registered into MS databases and thus was not available to the scientific community. Finally, the spectrum was included for the first time in a commercial library, namely the FFNSC 5.0 MS database. The aim of the present study was to highlight the opportunity to make analytical data quickly available in a reliable way by registering them in searchable MS databases to improve the identification means for researchers all over the world.
Text Line Extraction in Historical Documents Using Mask R-CNN
Authors: Droby Ahmad , Kurar Barakat Berat , Alaasam Reem , Madi Boraq , Rabaev Irina , El-Sana Jihad
Published: August 2022

Text line extraction is an essential preprocessing step in many handwritten document image analysis tasks. It includes detecting text lines in a document image and segmenting the regions of each detected line. Deep learning-based methods are frequently used for text line detection. However, only a limited number of methods tackle the problems of detection and segmentation together. This paper proposes a holistic method that applies Mask R-CNN for text line extraction. A Mask R-CNN model is trained to extract text lines fractions from document patches, which are further merged to form the text lines of an entire page. The presented method was evaluated on the two well-known datasets of historical documents, DIVA-HisDB and ICDAR 2015-HTR, and achieved state-of-the-art results. In addition, we introduce a new challenging dataset of Arabic historical manuscripts, VML-AHTE, where numerous diacritics are present. We show that the presented Mask R-CNN-based method can successfully segment text lines, even in such a challenging scenario.
A Comparative Study of Quantum Dot Solar Cell with Two Different ETLs of WS2 and IGZO Using SCAPS-1D Simulator
Authors: Naureen  , Sadanand  , Lohia Pooja , Dwivedi Dilip , Ameen Sadia
Published: August 2022

Quantum dot solar cells have received significant attention in comparison to standard solar cells because of their hybrid nature, low production costs, and higher power conversion efficiency. Although quantum dot solar cells (QDSCs) have several benefits over ordinary solar cells, their performance lags due to carrier combination within the quasi-neutral region (QNR). The electron transport layer (ETL) and hole transport layer (HTL) are the two layers that have the most effect on QDSC performance. This numerical analysis is carried out by using the Solar Cell Capacitance Simulator-1 dimensional software (SCAPS-1D). In this paper, the optimization of two different device structure investigations is performed. In this proposed device structure, WS2 and IGZO are used as two ETL, CdS is used as a buffer layer, Sb2Se3 is used as an absorber layer, and PbS as HTL. Initially, the optimization of the device has been performed, followed by depth analysis of the doping densities. Resistance analysis is also performed to illustrate the effect of resistance on the device. Further, the impact of temperature on the device parameters is also represented, followed by a contour plot between thickness and bandgap for both devices. The impact of the series and shunt resistance on the performance of the solar cell is investigated. The effect of temperature is studied further, and it is observed that the solar device is temperature-sensitive. Finally, the optimized performance with IGZO ETL with PCE of 20.94% is achieved.
Tourists Becoming Involved: The Influence of Pro-Environmental Voluntourism on Destination Image Formation
Authors: Lis Weronika , Dymitrow Mirek , Grzelak-Kostulska Elżbieta
Published: August 2022

The purpose of this research was to explore the realization of the pro-environmental initiative in the Faroe Islands in which tourists were involved as volunteers. The research was aimed at understanding how this influences tourists’ perceptions of a destination. We were interested in filling the research gap regarding the importance of tourists’ direct involvement in pro-environmental initiatives in terms of how this experience stimulates their perceptions of a destination image. The quantitative research method was adopted, whereby surveys were conducted among volunteering tourists and regular tourists visiting the Faroe Islands archipelago. The latter group was divided into two subsamples of arriving and departing tourists to understand how their perception changed after the visit. This study challenges the assumptions of the destination image theory, according to which only “accidental” information can affect the organic image of a destination within the mind of a tourist. The study reveals that tourists who tangibly experience a green marketing initiative have a positive opinion about the destination in terms of environmental protection. The organic image itself can be changed through purposeful action on the part of destination managers. We show the importance of the direct involvement of tourists in a volunteering project that is considered valuable in promoting the destination’s environmental image.
A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data
Authors: Tarazona Jose V. , Cattaneo Irene , Niemann Lars , Pedraza-Diaz Susana , González-Caballero Maria Carmen , de Alba-Gonzalez Mercedes , Cañas Ana , Dominguez-Morueco Noelia , Esteban-López Marta , Castaño Argelia , Borges Teresa , Katsonouri Andromachi , Makris Konstantinos C. , Ottenbros Ilse , Mol Hans , De Decker Annelies , Morrens Bert , Berman Tamar , Barnett-Itzhaki Zohar , Probst-Hensch Nicole , Fuhrimann Samuel , Tratnik Janja Snoj , Horvat Milena , Rambaud Loic , Riou Margaux , Schoeters Greet , Govarts Eva , Kolossa-Gehring Marike , Weber Till , Apel Petra , Namorado Sonia , Santonen Tiina
Published: August 2022

Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk assessment. Tier I was a conservative screening for overall pyrethroid exposure, based on phenoxybenzoic acid metabolites. Subsequently, probabilistic approaches and more specific metabolites were used for refining the risk estimates. Exposure was based on 95th percentiles from HBM4EU aligned studies (2014–2021) covering children in Belgium, Cyprus, France, Israel, Slovenia, and The Netherlands and adults in France, Germany, Israel, and Switzerland. In all children populations, the 95th percentiles for 3-phenoxybenzoic acid (3-PBA) exceeded the screening value. The probabilistic refinement quantified the risk level of the most exposed population (Belgium) at 2% or between 1–0.1% depending on the assumptions. In the substance specific assessments, the 95th percentiles of urinary concentrations in the aligned studies were well below the respective human biomonitoring guidance values (HBM-GVs). Both information sets were combined for refining the combined risk. Overall, the HBM data suggest a low health concern, at population level, related to pyrethroid exposure for the populations covered by the studies, even though a potential risk for highly exposed children cannot be completely excluded. The proposed tiered approach, including a screening step and several refinement options, seems to be a promising tool of scientific and regulatory value in future.
Optimised Non-Coding Regions of mRNA SARS-CoV-2 Vaccine CV2CoV Improves Homologous and Heterologous Neutralising Antibody Responses
Authors: Roth Nicole , Schön Jacob , Hoffmann Donata , Thran Moritz , Thess Andreas , Mueller Stefan O. , Petsch Benjamin , Rauch Susanne
Published: August 2022

More than two years after the emergence of SARS-CoV-2, 33 COVID-19 vaccines, based on different platforms, have been approved in 197 countries. Novel variants that are less efficiently neutralised by antibodies raised against ancestral SARS-CoV-2 are circulating, highlighting the need to adapt vaccination strategies. Here, we compare the immunogenicity of a first-generation mRNA vaccine candidate, CVnCoV, with a second-generation mRNA vaccine candidate, CV2CoV, in rats. Higher levels of spike (S) protein expression were observed in cell culture with the CV2CoV mRNA than with the CVnCoV mRNA. Vaccination with CV2CoV also induced higher titres of virus neutralising antibodies with accelerated kinetics in rats compared with CVnCoV. Significant cross-neutralisation of the SARS-CoV-2 variants, Alpha (B.1.1.7), Beta (B.1.351), and the ‘mink’ variant (B1.1.298) that were circulating at the time in early 2021 were also demonstrated. In addition, CV2CoV induced higher levels of antibodies at lower doses than CVnCoV, suggesting that dose-sparing could be possible with the next-generation SARS-CoV-2 vaccine, which could improve worldwide vaccine supply.
Fast Tracking—Vaccine Safety, Efficacy, and Lessons Learned: A Narrative Review
Authors: Wong Jason C. , Lao Crystal T. , Yousif Melanie M. , Luga Jacqueline M.
Published: August 2022

(1) Background: The COVID-19 pandemic has led to the fast-tracked development of vaccines under emergency use authorization. In light of the growing concerns about fast-tracked vaccines, this article reviews the safety, efficacy, and lessons learned of previously fast-tracked vaccines. (2) Methods: An article search regarding the safety and efficacy of fast-tracked vaccines was done in PubMed, Embase, Web of Science, and ScienceDirect. Of the 104 results, 24 articles were included. Five articles about BiovaxID, THERATOPE®, Sipuleucel-T, and AIDSVAX were also reviewed. (3) Results: The overall efficacy was shown to be 77–100%, with seroprotection against the viruses ranging from 87 to 100%. The antibody responses for optimal protection against the viruses fall within 85–97%. Generally, the fast-tracked vaccines were well-tolerated and had few significant adverse events, except for the H1N1 pandemic vaccine and its association with narcolepsy. To have accurate, precise, and timely fast-tracked vaccines, communication, sharing resources/data, and improving the current structures/outbreak operations are crucial. (4) Conclusions: This review found the FDA’s fast-tracking process for vaccines to have rigorous standards similar to the normal process. The previous fast-tracked vaccines were safe and efficacious. The lessons drawn from previous studies highlighted the significance of planning and utilizing global resources during significant outbreaks.
Attitudes towards COVID-19 Booster Vaccines, Vaccine Preferences, Child Immunization, and Recent Issues in Vaccination among University Students in Jordan
Authors: Ryalat Soukaina , Alduraidi Hamza , Al-Ryalat Saif Aldeen , Alzu’bi Marah , Alzyoud Muntaser , Odeh Nada , Alrawabdeh Jawad
Published: August 2022

Although COVID-19 vaccines have been available in Jordan for more than a year, Jordan suffers from a low vaccination rate. The aim of this study was to explore attitudes towards recent issues in vaccination among university students in Jordan. We adopted a cross sectional study design using an online questionnaire distributed in a Jordanian university with a medical school chosen at random. The survey asked about COVID-19 vaccine preferences, factors affecting COVID-19 vaccine preferences, child vaccination, and booster vaccines. A total of 417 students completed the survey. Most respondents (54.7%) preferred the Pfizer vaccine, and 6.2% refused to take any vaccine. Pfizer’s efficacy against new strains is a main factor in preferring Pfizer over other vaccines (p < 0.01). Most respondents (71%) believed that vaccination is crucial to prevent COVID-19 surges from new COVID-19 strains, while 44.6% of respondents believed that children should be included in vaccination campaigns, and 70% believed that booster vaccines required more studies to prove their efficacy. Students had mixed attitudes towards many recent issues concerning COVID-19 vaccination. Studying these factors and attitudes in more depth and in different populations can pave the way towards improving vaccination rates worldwide.
Ultrasonographic Findings of Exocrine Pancreatic Insufficiency in Dogs
Authors: Pelligra Tina , Puccinelli Caterina , Marchetti Veronica , Citi Simonetta
Published: August 2022

Exocrine pancreatic insufficiency (EPI) is a syndrome characterized by insufficient synthesis of pancreatic enzymes leading to clinical symptoms of malabsorption and maldigestion. There are no studies about ultrasonographic appearance of the pancreas with EPI in dogs. The purpose of this retrospective study was to describe ultrasound features of the pancreas during EPI in this species. Dogs with history and clinical signs of maldigestion, serum canine trypsin-like immunoreactivity (cTLI) values <5 µg/L, and abdominal ultrasound exam were included in the study. Size, shape, margin, echogenicity, echostructure, and pancreatic duct appearance of the right pancreatic lobe were valued. Additional sonographic intestinal findings were recorded. Thirty-four dogs were included. The mean pancreatic thickness in our population was significantly lower than the mean reference values of healthy dogs. In 68% of dogs, the pancreas had a normal ultrasound appearance. Ultrasonographic intestinal abnormal findings were identified in 85% of dogs and were suggestive of inflammatory bowel disease. Despite the fact that EPI is a functional diagnosis, ultrasound evaluation should be considered among the useful tests. The finding of a normal but thinned pancreas associated with sonographic intestinal signs of inflammatory bowel disease in dogs with typical history and supportive clinical signs could suggest a diagnosis of EPI.
Design and Performance Analysis of Super Highspeed Flywheel Rotor for Electric Vehicle
Authors: Wang Pengwei , Gu Tianqi , Sun Binbin , Liu Ruiyuan , Zhang Tiezhu , Yang Jinshan
Published: August 2022

The optimal design of a super highspeed flywheel rotor could improve flywheel battery energy density. The improvement of flywheel battery energy density could enhance the performance of the flywheel lithium battery composite energy storage system. However, there are still many problems in the structure, material and flywheel winding of super highspeed flywheels. Therefore, in this paper, electric flywheel energy and power density parameters are designed based on CPE (Continuous Power Energy) function and vehicle dynamics. Then, according to the design index requirements, the structure, size and material of the electric flywheel rotor are designed. Furthermore, the numerical analysis model of stress and displacement of multi-ring interference fit flywheel rotor under plane stress state is established. On this basis, the influence laws of flywheel rotor wheel flange numbers and interlaminar interference on stress distribution of flywheel rotor are analyzed, and the assembly form of wheel flange is determined. Finally, the stress check of the flywheel rotor is completed. The results show that the super highspeed flywheel rotor designed in this paper meets vehicle dynamics requirements in terms of energy storage and power. In terms of strength, it meets the design requirements of static assembly stress and dynamic stress at maximum speed.
State-of-Health Estimate for the Lithium-Ion Battery Based on Constant Voltage Current Entropy and Charging Duration
Authors: Luo Laijin , Zhang Chaolong , Tian Youhui , Liu Huihan
Published: August 2022

An accurate state-of-health (SOH) estimation is vital to guarantee the safety and reliability of a lithium-ion battery management system. In application, the electrical vehicles generally start charging when the battery is at a non-zero state of charge (SOC), which will influence the charging current, voltage and duration, greatly hindering many traditional health features to estimate the SOH. However, the constant voltage charging phase is not limited by the previous non-zero SOC starting charge. In order to overcome the difficulty, a method of estimating the battery SOH based on the information entropy of battery currents of the constant voltage charging phase and charging duration is proposed. Firstly, the time series of charging current data from the constant voltage phase are measured, and then the information entropy of battery currents and charging time are calculated as new indicators. The penalty coefficient and width factor of a support vector machine (SVM) improved by the sparrow search algorithm is utilized to establish the underlying mapping relationships between the current entropy, charging duration and battery SOH. Additionally, the results indicate the adaptability and effectiveness of the proposed approach for a battery pack and cell SOH estimation.
On the Theory of Marriage Invalidity or Once Again on the Correlation between the Notions of “Void”, “Voidable” and “Inexistent” Marriage
Authors: Mateeva Ekaterina
Published: August 2022

The present article is devoted to one of the most debated issues in the theory of family law, namely the one concerning the legal notions of “void” and “inexistent” marriage and the correlation between them. From the perspective of legal history, the author traces the origin and the subsequent development of the different views upon these notions, expressed in the legal theory, initiating from the Roman private law until present day. This enables the conclusion that the issues on the precise legal qualification of a marriage as “inexistent”, “void” and “voidable” one and on the exact litigious manner by which both the respective legal vice of the marriage and the legal consequences of such a marriage are resolved, is subjected to a great extent to the dominant legal views – religious (canonical) or secular, on the institute of marriage and marriage formation throughout the development of society.
Damage Caused by Another in the Course of his Employment under the English and Bulgarian Tort Law
Authors: Tsoneva Silvia
Published: August 2022

This paper deals with the vicarious liability of one party held liable for the damage caused by another in the course of his employment under the English and Bulgarian tort law. The legal framework and caselaw on vicarious liability in the two legal systems are explored and analyzed in comparison.
A Unique Comparative Legal Study from Late Antiquity (Collatio legum Mosaicarum et Romanarum)
Authors: Novkirishka-Stoyanova Malina
Published: August 2022

The article presents some of the main problems related to the study of a unique comparative legal work from Late Antiquity – Comparison of the law of Moses and Roman law (Collatio legum Mosaicarum et Romanarum). The manuscripts in which it is contained, its structure and content are examined. The author's generalizations of existing theories about his origin, authorship and purposes of compilation have a particular importance. The author maintains that if the work was originally composed in the late 3rd and early 4th centuries and had a rather pragmatic focus on the application of official Roman law among the Jewish communities, which had significant privileges and jurisdiction, then more later, interpolations were introduced for apologetic purposes, which does not exclude its application in epicopalis audientia. The general conclusion point to the creation a Collatio by one or more erudite and good lawyers and religious scholars who have made a brilliant comparison of the law of Moses and Roman law to achieve not only the specific goals of its time, but also to present a universal importance of law and religion in the protection of man and his values.
On Treaties’ Designation
Authors: Vidin Blagoy
Published: August 2022

Under consideration in the paper is the issue regarding treaties’ designation. It is well accepted that the concrete treaty designation is not crucial for the treaty. The analysis of the state practice of Bulgaria reveals, that there is distinction between the various types of treaties and that the designation is part of that distinction.
Nazi Decontextualization of the Bible
Authors: Hensley Jason
Published: August 2022

When spreading antisemitic ideology, Hitler and his followers sometimes turned to the Bible to verify and support their hatred of the Jews. Passages such as “you are of your father the devil,” were used to encourage Bible-believing Christians that Jesus himself was antisemitic and that those who held antipathy towards the Jews were following Jesus’s legacy. However, many of these passages that the Nazis used to support their antisemitism were taken out of context and the original intent of the author was ignored. Anti-Jewish Christian expositors also ignored the contexts of Biblical passages––expositors both during the time of the Nazis and earlier. This article will consider this decontextualization of the Bible by the Nazis and anti-Jewish theologians. It suggests that if the original meaning of the text has been obscured by decontextualization, the solution is not to reject the text as anti-Jewish, but rather to reevaluate the anti-Jewish interpretation and recontextualize the passage.
Atribuciones causales de éxito y fracaso en la elaboración de tesis de psicología
Authors: Gutiérrez Villa Gloria Margarita , La Rosa Cormack María Isabel
Published: August 2022

La presente investigación se realizó bajo el paradigma cualitativo y tuvo como objetivo conocer las causas atribuidas al éxito y fracaso en la elaboración de tesis de los estudiantes de las menciones de psicología clínica, educacional y social de una universidad privada de Lima. La principal fuente de información fue una entrevista semi-estructurada y, posteriormente, se realizó un proceso de validación con los participantes para verificar los resultados hallados. El asesor de tesis constituye la razón principal que atribuyen los participantes en este estudio al explicar sus resultados, seguido por su rol como tesistas, es decir las características que un tesista debería poseer, como el gusto, disfrute e interés por distintas partes de una investigación y su nivel de valoración sobre la elaboración de la tesis. Otras atribuciones encontradas fueron a la habilidad, al manejo de recursos, a las características personales, a la facilidad o dificultad para realizar una tesis, entre otras.
Male Characters in the works of Female Poets during Sangam Period
Authors: S Rathika
Published: August 2022

Men's characteristics have been mentioned in the perspective of women poets during the sangam period. When a men falls in love, to whom does he express it first, what are the efforts taken by the leader to win the love, the efforts of the men to see the heroine during the love period, what is the mood of men suffering from the excess of love, and the infamy that the men gets due to going along with heroine, for all these the love life of men gives answers. It is also said how the lust of a men is in a chastity life. And it can be known that a men's natural love is revealed when he is a father who shows true affection to his children and seeks the permission of his beloved in the act of doing. The habits and duties of men in daily life are also mentioned. It is also explained about the weakness of men and what are the activities that make men happy and sad. Who gets angry with men, the moments when men's anger is revealed, the way men reveal humor, and the moments when men are afraid have been explored and highlighted. Feminist poets have recorded in their songs about men's travel vehicle, entertainment, heroism, the way of exspressing the pain of separation, news about the heroine's father – brother and male workers. The news is known from male birds and animals, and also tells about the actions of a men who lived happily in his youth and also what he did after his ascetic life. This article is based to say all the above mentioned from the songs of sangam period womens.
The Effect of Educational Dietary Approaches to Stop Hypertension on Blood Pressure Changes in the Elderly in the Work Area of the Kutalimbaru Health Center Deli Serdang Regency in 2022
Authors: Simorangkir Lindawati , Ginting Agustaria , Veira Uli
Published: August 2022

Abstract

Hypertension is a non-communicable disease if not controlled can lead to complications of stroke and even death. The purpose of this study was to determine the effect of dietary approaches to stop hypertension on changes in blood pressure in the elderly in the work area of ​​the Kutalimbaru Health Center, Deli Serdang Regency in 2022. The research method used correlation with a one group pretest - posttest design. of 31 respondents, with purposive sampling technique. The data was taken directly using the observation sheet. The results of the study found that the mean pretest was 155.15 mm Hg where the standard deviation was 9.616, while the posttest mean was 147.74 mm Hg with a standard deviation of 8.835. The results of the research before and after the DASH intervention was given the Wilcoxon rank test statistical test results obtained a p value of <0.05 where the effect of DASH education on changes in blood pressure in the elderly in the working area of ​​the Kutalimbaru Public Health Center, Deli Serdang Regency in 2022. It is hoped that the results of this study can used as material when conducting education about the DASH diet for people with hypertension when conducting research, especially the elderly at the Kutalimbaru Public Health Center, Deli Serdang Regency because many respondents did not know about the DASH diet pattern
Pankreas Nöroendokrin Tümörlerinin Cerrahi Tedavisinde 11 Yıllık Tek Merkez Deneyimi
Authors: GÜNDOĞDU Ramazan , ERKAN Serkan , YABANOĞLU Hakan , ERTÖRER M. Eda , COŞKUNOĞLU Esra Zeynep , ÖZARSLAN Fatma
Published: August 2022

Giriş: Pankreatik nöroendokrin tümörler (pNET) nadir görülen hastalıklardır ve cerrahi ön planlı tedavi yüz güldürücüdür. Bu çalışmada hastanemizde son 11 yılda pankreatik nöroendokrin tümör nedeniyle cerrahi tedavi uygulanmış hastaları geriye dönük inceleyerek; bulgularımızı literatüre sunmayı amaçladık.
Materyal Metod: Ocak 2011 ile Mart 2022 tarihleri arasında pNET nedeniyle başvuran hastaların dosyaları geriye dönük incelendi. Çoklu veri eksiği olan, operasyon yapılmamış ve 18 yaşından küçük olan hastalar çalışma dışı bırakıldı. Hastalar yaş, cinsiyet, operasyon türü, tümör boyutu, tipi ve histolojik özellikleri, hastanede kalış, nüks hastalık ve sağ kalım açısından değerlendirildi.
Bulgular: Çalışmaya alınan 33 hastanın 13’ü kadın 20’si erkektı ve yaş ortanca değeri 56 (18-86) idi. Fonksiyonel tümörü olan 8 hasta vardı ve biri somatostatinoma olup diğerleri insülinomaydı. Hastaların 7’sine enükleasyon; 26’sına pankreatektomi yapıldı. Ana lezyonu adenokanser ve seröz kistadenom olup rezeksiyon uygulanan ve spesmen patolojisinde insidental pNET saptanan üç hasta vardı. Tümörü grade 1, 2 ve 3 olan sırasıyla 23, 7 ve 3 hastamız vardı. Tümör çapı ortanca değeri 24 (3-80) mm idi. Hastanede yatış süresi ortanca değeri 7 (2-50) gündü. Takip süresi ortanca değeri 24 (1-71) ay; hastalıksız sağ kalım 14 (1-71) aydı.
Tartışma ve Sonuç: pNET’ler nadir görülen ve insidental olarak da saptanabilen, titizlikle yönetilmesi gereken hastalıklardır. pNET’in cerrahi ve konservatif tedavisinde fikir birliği sağlanabilmesi için daha geniş serileri içeren çalışmalar yapılması gerekmektedir.
Mandibular Gömülü Üçüncü Molar Diş Pozisyonlarının Retrospektif Olarak Değerlendirilmesi
Authors: BİNGÜL Muhammet Bahattin , TANKUŞ Mahmut
Published: August 2022

Amaç: Bu çalışmada Şanlıurfa bölgesinde yaşayan bireylerin mandibular gömülü üçüncü molar diş pozisyonlarının değerlendirilmesi amaçlanmıştır.
Materyal-metot: Bu retrospektif çalışmada; 2017 ve 2020 yılları arasında Harran Üniversitesi Diş Hekimliği Fakültesi’ne, çeşitli sebeplerle başvuran 1096 hastanın (469 kadın, 627 erkek) panoramik radyografileri incelenmiştir. Dişlerin gömülülük durumu Winter ve Pell- Gregory sınıflandırmasına göre değerlendirilmiştir. Hastanın yaş ve cinsiyeti ile birlikte; dişlerin gömülü kalma oranları, lokalizasyonları, gömülülük seviyelerinin cinsiyete ve yaşa göre dağılımları kaydedilmiştir.
Bulgular: Bu çalışmada 1096 hastanın 2192 tane mandibular üçüncü molar dişi incelenmiştir. Cinsiyete göre dağılım incelendiğinde %42,79’u erkek ve %57,21’i ise kadındır. Cinsiyet ile mandibular üçüncü molar konumu arasında istatistiksel olarak anlamlı ilişki bulunmaktadır (p<0,05). Mandibular üçüncü molar dişlerin %60,81’i vertikal, %21,3’ü mezioangular, %9,03’ü horizontal, %0,09’u distoanguler, %0,14’ü bukkolingual pozisyonundadır. Mandibular üçüncü molar sürme seviyesi bakımından incelendiğinde ise %61,82 oranında A, %9,76 oranında B, %20,48 oranında C seviyesindedir. Cinsiyet ile mandibular üçüncü molar sürme seviyesi arasında istatistiksel olarak anlamlı ilişki bulunamamıştır (p>0,05).
Sonuç: Mandibular üçüncü molar dişler gömülü oldukları zaman çeşitli komplikasyonlara yol açabilmektedir. Bu yüzden bu dişlerin konumunun değerlendirilmesi önemli bir konudur.
Estudio de defensinas de flores de cardos con potencial aplicación biotecnológica
Authors:   , Fernández Agustina
Published: August 2022

Frente al ataque de un patógeno, las plantas pueden producir una gran diversidad de factores de defensa tales como metabolitos secundarios y una amplia gama de proteínas y péptidos antimicrobianos (AMPs), entre los que se encuentran las defensinas. Estas son pequeñas proteínas catiónicas ricas en cisteína cuya principal actividad reportada es la antifúngica, pero se han descripto también muchas otras acciones para estas proteínas. En vista su alto grado de conservación estructural, las diferencias en las especificidades y las múltiples actividades de estas proteínas pueden ser atribuidas a la variación en la secuencia aminoacídica y a la distribución de cargas de los loops expuestos al solvente que modulan su función biológica. En estos loops se localizan dos motivos importantes su actividad, el g-core, un motivo de relevancia para los AMPs en general, y el α-core que no ha sido estudiado en profundidad. Este trabajo de tesis describe la obtención y el estudio de nuevas proteínas de defensa de una especie vegetal silvestre de la flora argentina, que pueden resultar moléculas atractivas para su potencial aplicación agronómica o médica. Las especies silvestres constituyen una valiosa fuente de AMPs por su notable adaptación al medio ambiente, lo que resulta en una mayor resistencia a enfermedades en comparación con los cultivos agrícolas. A partir de ARNm de flores de Silybum marianum se clonaron dos defensinas (DefSm1D y DefSm2D), se realizó el análisis de las secuencias, la predicción de la estructura terciaria a través del modelado molecular por homología y su análisis funcional. Con el fin de profundizar el conocimiento de las relaciones estructura-función e identificar regiones relacionadas con la actividad antifúngica, a partir del estudio estructural de las defensinas se realizó el diseño racional péptidos derivados de las regiones g- y α-core. Se realizó la síntesis química de péptidos en fase sólida utilizando la estrategia Fmoc y se purificaron y analizaron por HPLC-RP, ESI-MS y CD. Se evaluó y caracterizó la acción de los péptidos sobre dos hongos fitopatógenos del género Fusarium. Los péptidos derivados de DefSm2D resultaron ser activos en concentraciones micromolares frente a Fusarium graminearum, un fitopatógeno que afecta al cultivo de trigo produciendo no sólo mermas significativas en el rendimiento sino también micotoxinas que permanecen en los granos. Se evaluó y caracterizó la actividad de los péptidos sobre conidios a través de distintas técnicas. Los péptidos derivados del α-core produjeron agregación de los conidios del hongo y un efecto diferencial sobre la morfología de la pared celular. Se estudió también la actividad de péptidos modificados, derivados de la región α-core. Nuestra investigación sugiere que las regiones α- y g-core estarían implicadas en la actividad antifúngica de la defensina de origen actuando mediante mecanismos diferenciales.
Várices del miembro inferior: tratamiento quirúrgico
Authors:   , Alfaro Romero Ismael
Published: August 2022

Temas tratados: Anatomía del sistema venoso del miembro inferior Fisiología Pruebas funcionales Tratamiento quirúrgico
Rabia: accidentes producidos por el tratamiento antirrábico
Authors:   , Rebollo Virginio Julio César
Published: August 2022

Accidentes locales Accidentes neuroparalíticos Casuística - Instituto Pasteur de La Plata
La osteomielitis del adolescente
Authors:   , Porjolovsky Isidoro
Published: August 2022

Índice - Introducción. Definición e historia. - Histología, propiedades y funcionamiento del tejido óseo - Etiopatogenia - Anatomía patológica - Sintomatología clínica/ Laboratorio - Diagnóstico. Formas clínicas - Diagnóstico radiológico - Diagnóstico diferencial - Pronóstico - Tratamiento - Bibliografía consultada - Historias clínicas
PROJECT AS A COMPLEX MULTIFUNCTIONAL SYSTEM IN THE ECONOMY
Authors: Belikova A.V. , Aleksandrova O.B.
Published: August 2022

The article considers a project as a basis of conscious activity in various spheres of the economy. Any project is implemented in order to meet specific human needs and is aimed at obtaining a certain result, which determines the significance and effectiveness of the project. The methodological basis of the study consists of general scientific methods, which allowed analyzing the available information and revealing the most significant aspects of the object under study. The role of a project considered in the work confirms its importance for the national economy. The authors analyze the conceptual framework, and give their interpretation of a project adapted to modern conditions. The established external and internal factors make it possible to take into account the influence of near and distant environment of a project in order to reduce their critical impact on the project result. The proposed scheme of movement through the stages of project implementation allows you to manage such project parameters as the duration of implementation, quality and to determine the choice of management method. Due to the large-scale application of a project in various fields of activity, modern economics needs a new look at a project as a system of interrelated elements, which determines the relevance of the chosen topic and requires careful and detailed study.
TOOLS TO BALANCE SUB-FEDERAL BUDGETS
Authors: Bushinskaya T.V.
Published: August 2022

The article considers the issues of balancing the sub-federal budget as an integral part of the budget system of the federal state. The Budget Code of the Russian Federation establishes the principle of balance, which enshrines the obligation to adopt a deficit-free budget and, if necessary, to determine the volume and sources of financing its deficit. However, a serious methodological and organisational problem is balancing the budget at the stage of implementation. The high degree of centralisation of fiscal powers in the federal centre, limited influence on the composition of sub-federal budgets and, consequently, on the balance of revenue and expenditure parts, predetermines the objective need to develop a concept of balancing the sub-federal budget. The purpose of this study is to identify and justify the tools of tax revenue management as a main source of budget revenues and an element of the multilevel concept of balancing the sub-federal budget. The methodological basis of this study is the systematic approach, methods of grouping, analysis and comparison. The works of Russian scientists on fiscal policy, balancing budgets, official data of Rosstat and the Federal Treasury were used as the information-empirical base. The result is the development of individual tools, ensuring a balanced budget and lying in the sphere of taxation management at the sub-federal level. The peculiarity of the proposed instruments is that they are within the competence of the authorities of the subjects of the Russian Federation, and their implementation does not require additional funding and does not entail additional administrative burden.
ROLE OF ACCOUNTS RECEIVABLE IN ACCOUNTING (FINANCIAL) STATEMENTS
Authors: Slesarenko G.V. , Bobyleva T.D.
Published: August 2022

Receivables in the financial statements are an important element that reflects the amount of an organization's funds diverted from turnover, those that are expected to be received in the near future. At the same time, receivables differ in terms of maturity, quality and it is necessary to analyze them in order to understand what share of the total amount of debt will actually return to the turnover of the organization. For analysis, you need to set up the accounting and analytical collateral system so that the entire accounts receivable management system is tailored to the needs of the users of this information. Understanding how much funds we actually have to pay off accounts payable, we can ensure the timely repayment of the organization's debts and improve solvency indicators. The organization's revenue reflects the amount of funds invested in production and commercial operations taking into account the profit received, therefore, its financial stability depends on the speed of the refund. Thus, accounts receivable management is a process aimed at improving its quality, return rate and more efficient use of funds. Performance indicators of accounts receivable reflect the speed of their circulation; their calculation and correct interpretation are an important element of analysis. The article provides an example of how the change in receivables affects the key performance indicators of the organization. Using this method, you can in practice calculate the performance indicators of the use of receivables for making decisions regarding their optimization.
STRATEGIC ASPECTS OF THE DEVELOPMENT OF REGIONAL PRODUCTION SYSTEMS
Authors: Sutygina A.I.
Published: August 2022

In the conditions of increasing political and economic sanctions against Russia, the significance of the economy development of the country grows. Provision of the competitive all-sufficiency of the production systems is of great importance. This will contribute to the creation of conditions for overcoming the crisis and raising the country’s export potential in future. It should combine balanced development of the economic agents included in them and also territories of factories location. This will allow connecting the territorial and sectorial aspects of strategic development. Influence of social, political and regulating norms predetermines the conditions and results of production systems functioning. In their turn, economic entities are able to carry out implementation of social tasks only with the condition of the efficiency of entrepreneurial activity and financial stability. Nowadays, the necessity of import substitution in all sectors of the economy is topical for the country. Due to the introduction of logistic restrictions and ban on the cooperation with the domestic companies, Russia doesn’t have possibility to take part in the world production chain of added values creation to the full measure. Therefore, aspiration to isolate Russia from the advanced technologies should be used for the development of productions based on our own elaborations.
MODERN TRENDS IN DIGITAL TRANSFORMATION OF INDUSTRIAL ENTERPRISES
Authors: Khomenko E.B. , Vatutina L.A. , Zlobina E.Yu.
Published: August 2022

The article is devoted to the analysis of modern trends in the digital transformation of Russian industry at the present stage of implementation of the results of the fourth industrial revolution. The analysis of the key tools for digital transformation of the activities of industrial enterprises was carried out, the role of import substitution in achieving the results of digitalization in the industry was emphasized; based on the results of the assessment of the digital maturity of Russian organizations, conclusions were drawn about the features of transformation processes in certain industries and sectors of the economy. The authors substantiate that one of the key trends in the digital transformation of industrial enterprises - digitalization leaders is the implementation of business models that contribute to the formation of digital value chains, product customization and production serving. The stages of implementing the digital transformation strategy of an industrial enterprise are disclosed, including: defining the goals of a digital initiative, technological audit, organizational changes and digitalization of business processes, creating a digital ecosystem. It is concluded that the leadership as a result of digital transformation was captured by those industrial enterprises that united a wide range of leading market players around themselves, achieving a collective economic effect. The resource constraints that hinder the pace of digital transformation in the sectors of the economy of most regions of Russia are revealed, the importance of implementing the "Strategy for the Digital Transformation of Manufacturing Industries ..." and the prospects for using the achievements of economic clustering as the basis for the formation of digital ecosystems are emphasized.
FORMATION OF THE INSTITUTION OF THE APPLICATION OF COMPULSORY MEDICAL MEASURES IN THE RUSSIAN STATE
Authors: Golikova O.A.
Published: August 2022

The issue of legal regulation of the use of compulsory treatment measures is of interest, since it contains a number of gaps regarding the development of the institution of formation itself. The article notes the importance of studying the normative material of the XVII century, since it allows you to get a more comprehensive idea of the legal status of persons who have violated the law and are subject to compulsory treatment. The methodological basis consisted of: the method of formal legal analysis of legal acts before the XVIII century; the historical and legal method made it possible to trace the formation of the institution of the use of compulsory medical measures. The aim of the work is to analyze the legal material and the positions of researchers regarding the use of compulsory medical measures before the XVIII century. Particular importance is given to the XVII century. Since that time, the state begins to pay attention to the problem of legal regulation of the situation of persons with mental disabilities and who have violated the law. In 1669 New proof articles are accepted, which for the first time speak about the insane who committed murder, endowing them with legal personality. The author comes to the conclusion that since the XVII century in Russia, the institution of the use of compulsory medical measures begins to form, as evidenced by the available legal acts. The article shows that the place of isolation and forced treatment was, as a rule, the church. Compulsory treatment was provided for males.
PROCEDURAL PROBLEMS ARISING DURING THE INSPECTION OF THE SCENE AT THE STAGE OF INITIATING A CRIMINAL CASE
Authors: Yulberdin A.A.
Published: August 2022

The purpose of this article is to study the procedural problems that arise during the inspection of the scene at the stage of initiating a criminal case. The article proposes to consider the procedural problems of this investigative action based on the grounds and conditions for its conduct. Special attention is paid to persons authorized to conduct an inspection of the scene of the incident, as well as situations that arise during its production, but are not regulated by the criminal procedural legislation. Various legal scholars have their own idea of the nature of the problems under study and how to solve them. In this regard, this scientific work provides a commentary on the most interesting scientific views, as well as the author's own proposals. In addition, the current law enforcement practice of resolving procedural problems in the production of an inspection of the scene during the pre-investigation check is considered. The subject of the work is the criminal procedural legislation of the Russian Federation. The research methodology was based on the deductive method, abstraction and comparison. The results of the study can be useful in law enforcement practice, in particular, in the production of investigative actions and supervision over their implementation. In addition, the results of the study can be useful in studying the science of criminal procedure and forensic science. The novelty of the scientific work lies in the fact that a comprehensive study of all the procedural features of the inspection of the scene of the incident at the stage of initiating a criminal case was carried out, as well as the ways to solve them in the light of law enforcement practice were suggested.
Effect of the different substrates on root pruning of Acacia auriculiformis A. Cunn. ex Benth. and Acacia mangium Willd. seedling in the nursery.
Authors: F Mankessi , Nzonza JS Moulambi , R Matondo , J-B Bassiloua , Ekomono C.G. Makouanzi , Panzou G. J. Loubota
Published: August 2022

The effects of different substrates and genotypes on root pruning were estimated in order to recommend a technical plan for the production of Acacia spp. in the nursery. Two randomized tests-- were conducted on Acacia auriculiformis A. Cunn. ex Benth and Acacia mangium Willd., in six types of substrates made of humus soil, crushed coal and fine sawdust in different proportions. After sprouting, young seedlings aged three weeks were transplanted into in SAPPI trays, alveolar cells filled with substrates and observed closely until planting season. A low dose of NPK fertilizer (20 20 20) in granule formulation (30g diluted in 10l of water) was provided weekly to the plants. Seedlings heights and diameters were measured during months 1, 2 and 3 in the acclimation area. When the planting age was reached, roots dry matter mass (RDM) was estimated for both species with the aim to appreciate seedling roots pruning. Results indicate that, at the planting age, seedlings from substrates 6 (75% soil + 25% charcoal) and 4 (50% soil + 50% charcoal) had the best growth performances, followed by plants from substrates 1 (75% sawdust + 25% charcoal) and 5 (50% soil + 25% charcoal + 25% sawdust). Substrate 5, because it does not generate compaction, was selected for plants production. A variance analysis revealed a genotype effect on root pruning (0.31g vs 0.24g respectively for Acacia auriculiformis A. Cunn. ex Benth. and Acacia mangium Willd). At the plantation age, this study results showed strong correlations between diameter and height (r = 0.65, P <0.001), diameter and (RDM) (r = 0.44; P <0.001) on the one hand, and between hei