bluuebunny/crossref_metadata_2025 huggingface dataset:
Collagen Scaffold and Lipoaspirate Fluid-derived Stem Cells for the Treatment of Cartilage Defects in a Rabbit Model
Authors: Benea Horea Rares Ciprian , Earar Kamel , Lattanzi Wanda , Quercia Vittorio , Berce Cristian , Soritau Olga , Saccomanno Maristella , Milano Giuseppe , Tomoaia Gheorghe , Cerchizan Diana , Mohan Aurel
Published: February 2020

The purpose of the present study was to assess and compare the chondroregenerative properties of PLA (processed lipoaspirate) and LAF (lipoaspirate fluid) cells, in a preclinical rabbit model of knee cartilage defect. The defects were repaired by a collagen I/III scaffold and added LAF-cells, PLA-cells or no cells, upon the study group. The results showed that collagen scaffolds seeded with LAF-derived stem cells appear to have slightly better activity and outcomes when compared to PLA-cells, in terms of cartilage regeneration.
NT-proBNP and Cardiovascular Dysfunction in Chronic Liver Disease
Authors: Dima Cozma Lucia Corina , Ghiciuc Cristina Mihaela , Mitu Florin , Dascalu Cristina Gena
Published: February 2020

Plasma NT-proBNP levels are elevated in heart disease, especially in the presence of ascites-edema syndrome and left ventricular overload. Previous studies have reported cardiovascular dysfunction correlated with the severity of liver damage. This prospective study enrolled 65 subjects with the diagnosis of liver cirrhosis, 82 with chronic hepatitis and 65 healthy subjects in the control group. In chronic hepatitis, NT-proBNP has been shown to be an early marker of diastolic dysfunction and left ventricular remodeling, while in liver cirrhosis it also correlated with portopulmonary hypertension.
The Influence of the Temperature Regime on the Mechanical Properties of the Thick Steel Sheets from Carbon and Low alloy Steels, Laminated to Thicknesses More than 40 mm
Authors: Bordei Marian , Sandu Andrei Victor , Papadatu Carmen Penelopi , Sandu Ioan Gabriel
Published: February 2020

Apparently, defects caused by failures in mechanical characteristics do not have a significant weight, but at a closer analysis it is noted that there are many lamination programs in which the thermal heat treatment is needed. These defects are generally not a reason for rejecting the plates, but annealing leads to increased specific consumption.
Chemical Ablation of the Submucosal Tissue in Volumetric Reduction of Inferior Turbinate
Authors: Rusescu Andreea , Pietrosanu Catalina , Ionita Irina , Stefanescu Cristian Dragos , Pantea Stoian Anca Mihaela , Camen Adrian , Zainea Viorel , Hainarosie Razvan
Published: February 2020

Throughout the years, minimally invasive methods have gained ground when considering the surgical field. Most of all, these techniques are used in tissue ablation as they associate less operative and postoperative bleeding, high rate of recovery, as well as minimal scaring. One of these minimally invasive methods refers to the use of chemical ablation or coblation when regarding tissues ablation, thus using a chemical reaction based technique despite the regular use of mechanical or thermal interactions in order to achieve tissue ablation. Widely used in the area of ENT surgery, coblation could easily be defined as an extremely effective technique in dealing with the submucosal tissue in volumetric reduction of inferior turbinate. Different length and angulation probes ensure the applicability of this technique to better correlate with any anatomical variants and local features of the targeted structures to be ablated. Although the duration of surgery by using this method is slightly higher than with the use of other inferior tubinate volumetric reduction techniques such as radiofrequency or use of the shaver, the low degree of postoperative discomfort and the good local hemostasis provided by this technique are markers that support its elective use if it is available for the surgeon.
The Use of ELISA and PCR in Identifying Correlations between Viral Infection and Benign Prostatic Hypertrophy
Authors: Spinu Dan , Bratu Ovidiu , Marcu Dragos , Mischianu Dan , Huica Radu , Surcel Mihaela , Munteanu Adriana , Socea Bogdan , Bodean Oana , Ursaciuc Cornel
Published: February 2020

Benign prostatic hyperplasia (BPH) is induced by a persistent local inflammatory process that leads to cell proliferation. Viral infections associated with immune deficiencies can trigger the chronic inflammation of the prostate. Therefore, we have investigated several viral expressions in BPH patients and tried to establish a link with the diagnosed hyperplasia. 50 patients with BPH without urinary tract infection were tested for the presence of the following viruses: human papilloma virus (HPV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV). These viruses are the most common cause of asymptomatic viral infections. HPV-specific DNA detection by polymerase chain reaction (PCR) was used for freshly surgical removed tissue sample. Both anti-CMV (IgG, IgM) and anti-EBV (IgG, IgM) antibodies were detected in the patients� serum with standard enzyme-Linked Immunosorbent Assay technique (ELISA). Specific HPV-DNA in prostate tissue was found only in 4% of patients, while 98% and 100% patients were positive for serum anti-CMV IgG or anti-EBV, proving intense earlier contact with the virus. IgM anti-CMV evaluation was found in around 10% of the cases which were also negative for EBV, sustaining that this was a non-acute infection. The findings showed that BPH may be associated with a chronic inflammation due to the post-viral infection with CMV or EBV, or secondary to the presence of these viruses in the prostate, while the involvement of HPV infection in BPH development is comparably lower. Our data suggests that viral investigation in BPH should be considered in the screening protocol of BPH as an indicator of possible inflammatory-mediated tumorigenesis of urinary tract.
Assessment of Giardia lamblia Infection Prevalence Using Lugol�s Iodine Staining Technique
Authors: Olariu Tudor Rares , Mazilu Octavian , Mihaescu Rodica , Ududec Titus , Timar Romulus , Bolintineanu Sorin , Petrescu Cristina , Gurban Camelia Vidita
Published: February 2020

Parasitic diseases have a worldwide distribution and represent an important public health problem. The aim of the present study was to evaluate the prevalence of intestinal parasitic infections in a Child Day Care Center from Western Romania using direct wet mount and concentration procedures of stool samples. One hundred sixty-four children aged 2-8 years were investigated. Stool examinations were performed using the iodine staining for the identification of protozoan cysts and the Willis-Hung concentration method for the identification of helminth eggs. Routine laboratory investigations were also conducted to evaluate the eosinophil count in the infected children. Intestinal parasitic infections were diagnosed in 47 cases (28.6%). Giardia lamblia (25%), Entamoeba coli (5.5%), Blastocystis hominis (1.2%), Ascaris lumbricoides (0.6%) and Trichuris trichiura (0.6%) were the only parasites identified. Among the children with parasitic infections we have determined association of two parasites in 7 (14.9%). We have found that in children with giardiasis the eosinophil values were increased (5.54�4.21%) compared to controls (3.69�1.48%) (p[0.01). Our findings suggest that giardiasis may be significantly prevalent in children attending day care centers in Western Romania. Efficient educational programs should be timely implemented in child care centers with the aim of providing appropriate infection control measures.
Salivary a-amylase Activity-a Novel Non-Invasive Biomarker in Clinical Pathology
Authors: Cozma Sebastian , Martu Cristian , Ghiciuc Cristina Mihaela , Patacchioli Francesca Romana , Cozma Lucia Corina Dima
Published: February 2020

Salivary biomarkers have developed into biological clinical research because they are accessible and easily obtained. Salivary a-amylase was proposed as an associat marker of salivary cortisol in assessing stress and at the same time as a possible non-invasive indicator of autonomic nervous system activation. Studies conducted so far have tested a-amylase activity in psychiatric disorders, diabetic neuropathy, lung disease, and autonomic nervous system activation in hypertension or heart failure.
The Influence of Synthesis Conditions on Hydroxyapatite Adsorption Characteristics in the Process of Zn(II) and Pb(II) Removal from Single and Binary Solutions
Authors: Patescu Rodica Elena , Simonescu Claudia Maria , Nechifor Gheorghe , Tardei Christu , Ionascu Ionela Camelia
Published: February 2020

Two types of nanohydroxyapatite samples have been obtained by wet chemical precipitation synthesis, involving calcium nitrate tetrahydrate and diammonium hydrogen phosphate as precursors in different conditions. Powders obtained were characterized by X-ray diffraction (XRD) and FTIR spectroscopy. The equilibrium isotherm models related with lead and zinc ions removal from synthetic aqueous solutions have been also investigated. According to this research study, it has been found that the nanohydroxyapatite samples show good heavy metals adsorption capacity, and selectivity for lead ions. It was also observed a slow decreasing of sorption capacity of heavy metal ions from binary solutions compared to that registered from single heavy metal ion solutions.
Understanding the Chromatographic Properties and Cytotoxicity of Hidrazinoselenazole Compounds by Computational Study
Authors: Cozma Alina C. , Grozav Adriana , Tarca Ioan C. , Zaharia Valentin , Bolboaca Sorana D. , Jantschi Lorentz
Published: February 2020

Selenium compounds have been proven to possess anti-inflammatory, anti-cancer, anti-bacterial and anti-viral activities. A series of fifteen synthesized hidrazinoselenazole was investigated to assess the chromatographic properties as function of structural features and the cytotoxicity as function of chromatographic properties and/or structural descriptors. The investigated chromatographic properties were retention factor, specific surface area of the solvent and chromatographic hydrophobicity index. The 3D model of the compounds was optimized using Hartree-Fock DFT/B3LYP method, 6-31+G* basis set both in vacuum and water with Spartan software (v.8). Furthermore, several quantitative structure-activity relationship (QSAR) descriptors were calculated with Spartan and Dragon (v. 5.5) software. Full search approach was used to construct simple and multiple linear regression models. No reliable model was identified for specific surface area of the solvent. The models with higher performances in estimation and prediction for retention factor and chromatographic hydrophobicity index proved the ones with Dragon descriptors and molecules optimized in water (retention factor: rloo2 (loo = leave-one-out analysis) = 0.9244; rtr2 (tr = training set) = 0.9652; rts2 (ts = test set) = 0.9606; chromatographic hydrophobicity index: rloo2 = 0.9489; rtr2 = 0.9592; rts2 = 0.9669). The cytotoxicity proved related neither to chromatographic properties nor with compounds� structural characteristics.
Application of Innovative Hydroxyapatite Materials in 3D Printing for Biocompatible Voice Implants
Authors: Musialik Wojciech , Nabialek Marcin , Letkiewicz Slawomir , Sandu Andrei Victor , Bloch Katarzyna
Published: February 2020

The paper presents the possibility of using an innovative hydroxyapatite filament Ca10(PO4)6(OH)2 for printing in 3D printers of bone implants and the possibility of using it during implantation with voice prostheses. The introduction of an additional colloidal silver composite in voice implants will contribute to the reduction of bacterial infections, fungal infections and granulomatous hyperplasia. The creation of a stable external ring of the vocal fistula will remove complications associated with it with enlargement of the fistula and leakiness of voice implants. The ability to print with a hydroxyapatite filament will allow digital pre-surgery modeling of bone implants suited to the needs of surgical procedures.
The Influence of Partial Substitution of Raw Materials with Heavy Ash on the Main Properties of Portland Cements
Authors: Oproiu Carmen , Voicu Georgeta , Nicoara Adrian Ionut , Badanoiu Alina Ioana
Published: February 2020

The use of wastes in cement industry have impact both from economic and environmental point of views. Wastes can be used in clinker manufacture (to substitute raw materials or as alternative fuel) as well as supplementary cementitious materials in cement. This paper presents results regarding the use of heavy ash (bottom ash) as component of raw mix used for the clinker manufacture. Two types of cements were obtained by the milling of clinker produced with/without heavy ash (HA) as component of raw mix and gypsum (2%). The compressive strengths of these cements was assessed on plastic mortars (water:binder = 1:2 ratio and binder:aggregate = 1:3 ratio), cast in prismatic moulds (14x14x160 mm3), hardened different periods of time comprised between 1 to 28 days. The hydration and hardening processes which occur in the cementitious systems with/without waste content were assessed on pastes with water to binder ratio of 0.5, hardened for 1 up to 90 days. X-ray diffraction (XRD) and complex thermal analysis (DTA-TG) were used for pastes� characterization. The composition of clinker was assessed by XRD and microstructure by scanning electron microscopy (SEM). The results obtained in the framework of this research do not show any important difference between the clinkers� characteristics produced with alternative raw material (heavy ash) as compared with the ones produced with natural raw materials. Also, the properties of cements produced of these clinkers are similar.
The Role of Hyperbaric Oxygen Therapy in the Management of Patients With Sudden Hearing Loss
Authors: Stefanescu Dragos Cristian , Hainarosie Razvan , Zainea Viorel , Corneci Dan , Jecan Radu Cristian
Published: February 2020

The therapeutic approach in sensorineural hearing loss (ISSNHL) is far from a consensual protocol among ENT (ear, nose and throat) doctors. The present paper describes our experience with Hyperbaric Oxygen Therapy (HBOT) as salvage treatment for selected patients with the sudden sensorineural hearing loss. The HBOT method has shown an efficacy of 50% in our study, as salvage treatment in ISSNHL after initially corticoids therapy. Thus, we can assert without doubt that HBOT represents a viable option for those patients who want to continue the effort to regain hearing. Under the auspices of the national ENT society, through a collective effort, can be achieved a therapeutic consensus in the sensorineural hearing loss. In this consensual document, HBOT can be found both as initial and salvage therapy, alone or in the multimodal therapeutical variant. Further, the National Health Insurance House should introduce the reimbursement of HBOT sessions in the methodological norms, in order to offer this new therapeutic solution to all patients.
Spectroscopic Study of the Interaction of Anticancer Drug Mitoxantrone with Sodium Cholate Aggregates
Authors: Enache Mirela , Toader Ana Maria
Published: February 2020

The focus of the present work is to investigate the interaction of anticancer drug mitoxantrone with sodium cholate (NaC) bile salt in phosphate buffer (pH 7.4) and carbonate buffer (pH 10) by UV-Visible absorption spectroscopy. The results indicate that mitoxantrone may bind to NaC monomers and micelles through electrostatic and hydrophobic interactions and the interaction with NaC induces the dissociation of dimers and higher aggregates of mitoxantrone. The stoichiometric ratio, binding constant, micelle/water partition coefficient and the corresponding thermodynamic parameters for binding and partitioning processes were estimated from the monomer absorbance changes occurred as a result of the interaction between mitoxantrone and NaC micelles. The binding process of mitoxantrone to NaC micelles is spontaneous and entropy controlled over the range of studied temperatures, at both pH values. The partition process of mitoxantrone between micellar and bulk aqueous phases is spontaneous and entropy controlled at pH 7.4 but enthalpy controlled at pH 10.
Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients
Authors: Bojinca Violeta , Popescu Claudiu , Balanescu Andra Rodica , Balanescu Serban Mihai , Bojinca Mihai
Published: February 2020

The objectives of the study were to evaluate bone metabolism in primary prostate cancer (PCa) patients prior to any treatment and to compare estrogens and anti-androgens in terms of bone metabolism. The study prospectively included consecutive patients with primary PCa who were proposed for radical prostatectomy and androgen deprivation therapy (ADT; either estrogens-group E, or anti-androgens -group A) and age-matched controls. Bone markers (osteoprotegerin -OPG; osteocalcin; deoxypyridinoline) were measured before treatment and after 6 months. Bone mineral density (BMD) was measured by dual X-ray absorptiometry before treatment and after 12 months (osteoporosis was defined as a spine or hip T score � -2.5). Continuous variables are reported as mean � standard deviation. The study included 30 controls (aged 70 � 6 years), 15 patients treated with estrogens (aged 71 � 6 years) and 15 patients with anti-androgens (aged 72 � 5 years). At baseline, 0% of controls, 33.3% of group E (p = 0.002 versus controls) and 53.3% of group A (p = 0.0001 versus controls) had osteoporosis. In group E, compared to baseline, OPG (4.67 � 1.38 versus 5.27 � 1.89; p = 0.043) and DPD (6.85 � 3.24 versus 8.63 � 2.42; p = 0.008) increased, while spine (0.99 � 0.32 versus 0.94 � 0.31; p = 0.019) BMD decreased. In group A, compared to baseline, OPG (6.37 � 3.04 versus 5.02 � 1.12; p = 0.041), spine (1.03 � 0.15 versus 0.89 � 0.15; p = 0.0003) and hip (0.82 � 0.18 versus 0.75 � 0.17; p = 0.003) BMD decreased. Osteoporosis is prevalent among hormone-na�ve PCa patients. Estrogens are associated with an increase of serum OPG, while anti-androgens with a decrease of serum OPG. Irrespective of ADT type, BMD still decreases in primary PCa patients.
The Role of Melatonin in the Management of Patients with Tinnitus
Authors: Stefanescu Dragos Cristian , Hainarosie Razvan , Zainea Viorel , Jecan Radu Cristian
Published: February 2020

The therapeutic approach in tinnitus is still an open subject. Perhaps, the correct approach would be the management of a patient with a chronic suffering that occurred at the active ageand who, in the absence of an adequate intervention, may be incapacitated. Sound therapy, counseling and cognitive behavioral psychotherapy are the widely accepted by specialized physicians in tinnitus. Patients are still looking for medical treatment and the physician is required to integrate new drugs into his or her therapeutic arsenal. Melatonin is a relatively recently introduced substance in Romania and its primary therapeutic use is in sleep disorders. The present paper describes our experience with melatonin as treatment for selected patients with tinnitus. The melatonin treatment has shown an efficacy of 80% in our study, as secondary treatment in tinnitus after initially counseling. The obtained results can also be a prerequisite for the integrative approach of the patients with tinnitus in the context of the pathological conditions and not as an isolated clinical picture. Considering the etiopathogenetic mechanisms of tinnitus and the other therapeutic effects of melatonin (central nervous system modulator and antioxidant), more extensive and multicenter studies are needed.
Tumor Immune Response in the Presence of a Cytotoxic Peptide
Authors: Stefanache Teodor , Jitaru Daniela , Dragos Mihaiela Loredana , Badescu Magda , Diaconescu Bogdan Mihail , Ciocoiu Manuela , Mocanu Madalina , Badescu Codruta
Published: February 2020

We evaluated, by the flow cytometry technique, the viability of two tumor cell lines: colorectal carcinoma (HT-29) and human A549 arcinoma incubated with the cytotoxic peptide LL-37. The results obtained for the two cell lines HT-29 and A549 are significantly different under the action of cathelicidin LL-37. At high concentrations of 20mM, cellular apoptosis was over 30% higher for colorectal adenocarcinoma line compared to that by peptide exposure. Apoptosis was also significant in low-concentration (4uM) catechidine-labeled lung cancer cells for 48 h. Also, optimization of primers was sought to evaluate gene expression for, Bcl2, IL6, IL8. Determination of gene expression for these molecular targets under the action of the cytotoxic peptide was performed in order to evaluate the immune response of tumor cells. For this purpose, the genetic material (RNA) was extracted from cell cultures and reversed in cDNA, which was subsequently amplified by the qRT-PCR technique. Evaluation of tumor cell metabolism was done by determining the gene expression for Bcl2, IL6, IL8 by the action of the cytotoxic peptides used. The cytotoxic effect of cathelicidin LL-37 for the two cell lines HT29 and A549 is supported by the decrease in IL-6 and IL-8 gene expression. The increase in Bcl2 expression for cells exposed to the action of the peptide is explained by the increase in anti-apoptotic protein synthesis that explains the fight of tumor cells for survival and proliferation.
The Structural and Compositional Evaluation of Some Calcium Phosphate Glasses with Bioactive Potential
Authors: Avram Daniela , Ungureanu Dan , Angelescu Nicolae , Ionita Ionica , Gheboianu Anca , Bancuta Iulian , Popescu Elena Corina
Published: February 2020

This paper shows the experimental results of two compositional phosphocalcic glasses: 50% SiO2 - 45% CaO - 5% P2O5 and 47% SiO2 - 45% CaO - 5% P2O5 - 3% Ag2O obtained through sol-gel method. In order to study their bioactivity, the two compositions were structural analyzed by X-ray diffraction method. In this case the apatite formation was highlighted after 14 days of soaked in simulated body fluid, but also other compounds (CaCO3, AgCl and Ag) resulting from the same process were highlighted. The first glass composition is more bioactive than composition doped with silver. The pores of the hydrated silica network are partially clogged by the AgCl formed, which can reduce the rate of hydroxyapatite formation but this process does not cancel the bioactivity of the doped glass. The functional groups present in the structure of those two glasses before and after soaking (PO43-, CO32- and HO-) were highlighted by the Fourier Transform Infrared Spectroscopy (FTIR). The elemental chemical composition was confirmed by elemental analysis WD-XRF. The particle size and the two samples stability was analyzed by Dynamic Light Scattering (DLS), Thermogravimetric Analysis (TG) and Differential Scanning Calorimetry (DSC). The granulometric analysis shows that the glass particles have average diameters of 647.9 nm for the first composition, respectively 380.4 nm for glass doped with silver. TG analysis show a total loss of weight of 8.3% for the first glass, respectively 3.72% for doped glass, which demonstrates that the two compositions are thermally stable.
Liquid Fertilizers with Organic Substances - Agrochemical Effects Obtained by Application
Authors: Sirbu Carmen , Cioroianu Traian , Marin Nicoleta , Rujoi Bogdan
Published: February 2020

The fertilization methods and technologies rapid development using extra-radicular fertilizers and liquid fertilizers with or without organic substances is due to both their controlled application possibilities depending on the vegetation phases, crop, agrochemical background, and nutrition deficiencies and efficiency increase of the indices regarding the fertilization costs -economical results The best agricultural practices application, compatible with the new climatic conditions, can actively contribute to environment preservation and protection at the same time with crops constancy and production capability securement. Fertilizers application with solid or liquid humic substances ensures all the needed compounds and minerals for creating and maintaining a fertile soil. At the same time their efficiency depends on multiple factors that include temperature, humidity, previous agricultural practices, soil physical and chemical characteristics, pesticides or other polluting products residues, microbial population present in the soil and the activity it develops. The humic compounds mediate pesticides and toxins degradation and contaminated soils biological reparation rests on humus help in microbial degradation. The paper presents the results obtained by radicular application of two experimental NPK type fertilizers with humic substances at the sunflower crop in vegetation pots. The fertilizers have been physically and chemically characterized and agrochemically tested as compared to an unfertilized control and two fertilized controls with a complex 15.15.15 NPK fertilizer in 120 and 180 kg/ha doses. The experimental fertilizers were applied in portions upon crops sowing and during vegetation in three 200, 300, respectively 400 liters fertilizer/ha and ensured significant gains as compared to the controls.The extracted humic substances and the fertilizers were physically and chemically characterized as well as through differential thermal gravimetric analysis and FT-IR spectrometry. The vegetal material and the sunflower seeds were analyzed regarding the nitrogen phosphorus, potassium, calcium, magnesium, zinc, copper, iron, and manganese contents.
Toxicity and removal of Direct Red 28 diazo dye in living polymeric systems
Authors: Lobiuc Andrei , Olaru Stefan , Hancu Elena Iren , Costica Naela , Fortuna Maria Emiliana , Zamfirache Maria Magdalena , Constantinescu Gabriel
Published: February 2020

Aquatic environments are often contaminated with various compounds, with potential toxicity towards aquatic organisms, which may enter the food chain. Azo dyes are used in various industries and contamination of waters has been reported. The present paper assesses the toxicity of the synthetic, water soluble Congo Red dye towards Lemna minor from a physiological and cytogenetical point of view. The dye was tested in 5-5000 ppm concentrations. Total frond surface, root growth and fresh mass reductions were registered from 5 ppm dye concentration, with a concentration-dependent response and calculated EC50 of 1530 ppm. Plant growth was completely inhibited above 2500 ppm. Dye accumulation was observed in tissues, along with necrosis formation. Chlorophyll a contents decreased, while carotenoid contents increased above 2500 ppm. Significant inhibition of PSII efficiency was recorded above 1000 ppm. Mitotic indices were decreased at 5 and 1000 ppm dye and were 0 at 5000 ppm. The number of chromosomal aberrations significantly increased at 5 and 1000 ppm dye. The growth medium was decontaminated up to 56% at 250 ppm dye concentration by Lemna plants. Congo Red azo dye presented toxicity towards Lemna minor, from a physiological and cyotgenetical point of view, especially at higher concentrations. In the same time, a phytoremediation potential of duckweed with respect to the tested dye was demonstrated.
Chemical Features of Bisphosphonates and Histopathological Outcomes in Rat Jaw Treated with Zoledronic Acid Combined with Dexamethasone
Authors: Albu Stan Ioana Aurita , Petrovan Cecilia , Cerghizan Diana , Albu Daniel Emil , Craciun Adriana Elena , Copotoiu Constantin
Published: February 2020

Bisphosphonate related osteonecrosis of the jaws (BRONJ) is a pathological entity described for the first time in 2003; three criteria are mandatory: no radiotion therapy,exposed bone in oral cavities for at least eight weeks with no signs of healing, bisphosphonate therapy in present or in the past,in patients with bisphosphonate therapy in present or in the past. Bisphosphonates (BPs) are stable analogues of natural inorganic pyrophosphate, which inhibit bone resorption. In literature, most patients diagnosed with BRONJ were suffering from multiple myeloma and they had a treatment with nitrogen containing BPs and steroids such as dexamethasone intravenously. With this study we have aimed to achieve a rat model of BRONJ and to evaluate histopathological findings how concurrent use of BPs and steroids can affect emergence of BRONJ in this study.
Getting Oil Pipes High Strength Quenched and Tempered Condition
Authors: Rusanescu Carmen Otilia , Voicu Gheorghe , Rusanescu Marin , Biris Sorin Stefan
Published: February 2020

The use of the steel with low carbon and fine grain Cr-Mo type is asked by the necessity to fit high strength and plasticity characteristics. The paper emphasizes the quenched and tempered high strength pipes from groups II, III and IV � API 5 CT obtaining. The laboratory experiments followed the establishment of optimum values of the heat treatment parameters. Saying all these to ensure the obtaining of the mechanical characteristics specific to eachs grade that was to be obtained. Were used microalloyied steels with vanadium and columbium, that refined the structure of improved the materials toughness. The paper is determined hardenability and finishing elements influence the use of grain (V, Nb) on hardenability.
Nonacog Alpha - an Efficient Therapeutic Option in Hemostase Management for Hemophilia Type B in Patients with Elective Arthropalsties
Authors: Badulescu Oana Viola , Tudor Razvan , Friedl Wilhelm , Ciocoiu Manuela , Sirbu Paul Dan
Published: February 2020

Hemophilia is a hereditary coagulopathy that is largely in the attention of developing countries, not because of its low incidence, but because of the high costs involved in the treatment of the disease and its disabling consequences of the disease, if treated inappropriately. The concentrates of coagulation factors currently available for the substitution treatment of hemophilic patients have undergone additional viral purification and inactivation techniques, in order to achieve a higher infectious safety, an aspect that also implies an increase in treatment costs for these patients. Currently, the major morbidity of patients with hemophilia is represented by the disabling articular pathology, secondary to repetitive bleeding episodes developed in the articular space. Although it has been proved that the prophylactic administration of coagulation factors helps to prevent joint disease in the case of patients that were not subject to prophylaxis, the repeated bleeding in the joints induces synovitis, which is irreversible and may progress despite subsequent prophylaxis. Under these conditions, total joint arthroplasty remains the only solution to reduce both, pain and subsequent bleeding episodes of hemophilic arthropathy. Effective hemostasis is a basic condition for successful interventions in hemophilic patients. In this regard, this paper aims to highlight the effectiveness of Nonacog Alpha, a product that contains recombinant factor IX, in the management of hemostasis, in the case of a patient with type B hemophilia, with indication of total endoprosthesis of the left hip.
Prediction of Water Vapor Concentration of Moist Air inside Batch Solar Dryers
Authors: Ghiaus Adrian Gabriel , Caouris Yannis , Fatu Viorel
Published: February 2020

Design optimization and evaluation of existing solar dryers can be done through numerical simulation of the complex and coupled transfer processes taking place inside drying units. Analysis of moisture concentration and relative humidity evolution of the drying air along with pressure, velocity and temperature profiles was done both inside the solar collector and drying chamber. Prediction of operation parameters for different design configurations allowed the identification of unwanted recirculation regions, saturation moist air zones and optimum operation time for an efficient drying process.
Ureteral JJ Stent � Which One is Better?
Authors: Spinu Arsenie Dan , Marcu Radu Dragos , Socea Bogdan , Diaconu Camelia Cristina , Scarneciu Ioan , Scarneciu Camelia , Bodean Oana Maria , Dragomirescu Razvan Ion Florin , Stanescu Ana Maria Alexandra , Mischianu Dan Liviu Dorel , Bratu Ovidiu Gabriel
Published: February 2020

Ureteral stents represent a minimally invasive alternative to preserve urinary drainage whenever the ureter is damaged or is under a significant risk to be occluded due to extrinsic or intrinsic etiology, even due to iatrogenic cause. Ureteral obstruction caused by extrinsic compression is often associated with intra-abdominal neoplasms. The first-line therapy to relieve such obstructions is usually internal drainage with ureteral stents. Ureteral stents made of different materials have been designed to achieve the best drainage possible. In this study, we tried to compare different JJ stent materials � which are better and their pros and cons. The ideal stent that would combine perfect long-term efficacy with no stent-related morbidity is still lacking and stent usage is associated with several adverse effects that limit its value as a tool for long-term urinary drainage. Several new ideas on stent design, composition material and stent coating are currently under evaluation, and are trying to eliminate the drawbacks of ureteral stent usage. Almost every clinician is familiar with the drawbacks that are associated with stents, including infection, encrustation, pain and discomfort.
Validation and Optimization of a Method for Sb Determination from Bottled Natural Mineral Waters by ICP-OES
Authors: Capra Luiza , Manolache Mihaela , Ion Ion , Stoica Rusandica , Ion Alina Catrinel
Published: February 2020

In the present work, it was developed a simple, cheap and quick method for Sb determination from mineral water, using ICP-OES, using two different calibration proceedings: calibration curve method (CCM) and standard additions method (SAM). On the studied concentration range, the parameters such as the calibration curve slope, linearity expressed through correlation coefficient r = 0.9992, limits of detection LoD = 0.67 �g L-1 and quantification LoQ = 2.01 �g L-1, the standard deviation of repeatability of 0.25 �g L-1, the accuracy of 0.16 �g L-1 satisfy the performance criteria. The value of extended uncertainty with a confidence level of 95 % (k = 2), is 1.0 �g L-1 obtained for Sb content of 4.10 �g L-1. The mineral waters were analyzed also by the addition standard method. One of the advantages of this method is to eliminate interference from the matrix. By the method of standard additions, the detection limit decreased from LoD=0.67 �g L-1 to 0.16 �gL-1.
Study on Alumina Supported Heterogeneous Catalysts for Biodiesel Production
Authors: Raducanu Cristian Eugen , Gavrila Adina Ionuta , Dobre Tanase , Chipurici Petre
Published: February 2020

In this work four heterogeneous catalysts were studied first by preparing a gama-alumina catalytic support then by impregnating with acidic and base compounds to gain certain properties needed to catalyze vegetable oils conversion to biodiesel. The resulted new catalytic properties allowed us to simultaneously conduct esterification and transesterification reaction in a single step when waste cooking oils with a high free fatty acid content were converted to biodiesel. The prepared catalysts were thermally and chemically stable and exhibited good catalytic activity when tested in (trans)esterification reactions to yield biodiesel. The effects of catalyst loading, methanol/oil molar ratio and reaction time on biodiesel yield along with catalyst reusability were investigated. The highest biodiesel yield reached was 88.10% at 65oC reaction temperature, 15:1 methanol/oil molar ratio, 5% catalyst loading and 4 h reaction time.
Melatonin Supplementation Under Hypobaric Hypoxia and Hypothermia Conditions
Authors: David Sergiu , Nagy Andras , Moldovan Remus , Orasan Remus , Bidian Cristina
Published: February 2020

The presence of oxidative and nitrosative stress under hypobaric hypoxia and hypothermia conditions led us to experimentally study the effect of the administration of melatonin as a non-nutritional antioxidant in rats. Morphological changes in the lungs and heart were monitored under hypobaric hypoxia and hypothermia conditions, with and without melatonin supplementation. Melatonin partially corrected the changes induced by hypothermia in the lungs and by hypoxia in the myocardium.
The Role of Arthroscopy in the Treatment of Gouty Arthritis of the Knee Case presentation
Authors: Moga Marius , Pogarasteanu Mark Edward , Ferechide Dumitru , Edu Antoine , Ifrim Chen Feng
Published: February 2020

Gout is a metabolic disease involving the impregnation of joints and other tissues with urate crystals. The onset is often brutal, and it manifests itself with pain and inflammation in the affected joint. The treatment usually involves rest, ice, NSAIDs and anti-gout medication. The long-term treatment involves medication and dietary changes. In the joint, urate crystals are deposited in the synovial, in the cartilage and in the menisci. In the arthroscopic practice, the gouty knee is a rare occurrence. We present a relevant case, that of a 57 years old patient without a prior gout diagnosis where we found urate crystal deposits covering the synovium, cartilage and meniscus, and we discuss the current and recent year Pub Med indexed literature in order to evaluate the possibilities for arthroscopic treatment of this pathology. We looked at the number of patients involved, their characteristics, and the surgical techniques used. We also looked at the temporal relation of the arthroscopic intervention to the recent gout attacks, and at the described lesions that were found. Also, we evaluated the papers for joint liquid analysis, gout drug treatment, and description of clinical aspects involved and associated lesions. Finally, we looked at the follow-up, at the functional scores used to monitor the patient�s evolution, at the associated medication and at the long-term outcomes, if described. We have found opinions to vary. In the end, we draw conclusions pertaining to the practical short-term and long-term use of knee arthroscopy in the treatment of gout.
The Chemical Effect in Medicine Interaction Determining the Form and Speed of Psychical Involution in the Prosthetic Restauration in the Edentulous
Authors: Caraiane Aureliana , Leata Razvan , Toba Veronica , Vesa Doina , Macovei Luana Andreea , Dan Cristian Ionel , Pavel Liliana
Published: February 2020

The progress made in dentistry during the latest decades is due, conceptually, to the new, systemic vision of man, which has also taken place in this field of medicine. In this context, the link between organic and psychic is indestructible. Thus illness is understood as a drama in which the somatic process has a psychic value, and the mental one has a body value. It is known that the morphological and functional integrity of the dental system, health and vigorousness, gives the individual a state of well-being that affects his somatic and psychic health, as any disturbance at this level entails repercussions in psychological and social behavior. Such a disruption is the total edification that seriously alters not only the dental system but the whole organism, putting various biological and psychosocial problems to the practitioner. The total expression represents not only a physical disability but also a psychological one. A special importance in studying psychological changes at total edentulous presents the psychological aspects of senile involution. This is not only a theoretical but also a practical importance due to the increase in the number of elderly people. Through the researches of the present paper we intend to present the reality of the psychological manifestations in the total edentation, which is objectified on different methods of psychodiagnosis in the first part, in order for the second part to be addressed to problems of prosthetic psychotherapy.The study comprises a group of 43 patients, of whom 24 were men and 19 women with total uni or bimaxilar edentation. Total edentation can be and is responsible for somatopsychic alterations, along with other pathogens, general, local, social, which sometimes can take a dramatic form, converting, where the area is also favorable, a pure somatic disease, for those who are not in psychopathy or even psychosis, although these latter cases are extremely rare and especially in youngsters, which would disrupt not only the person�s behavior as an individual, but also their status, function and social integrity. The treatment of dental and psychological complex is mandatory for any patient, but especially for the elderly, where recovery is more difficult, with disease-specific disorders adding to those of senescence.
The Benefits of Using the Iodine Solution in the Treatment of Acne at Pregnant Women
Authors: Taranu Tatiana , Constantin Maria Magdalena , Toader Mihaela Paula , Esanu Irina , Mocanu Madalina
Published: February 2020

Acne treatment during pregnancy is challenging and should be adapted to the clinical form, the lesions severity and their impact on the patient�s quality of life. The therapeutic decision in such cases need to be based on the risk / benefit ratio and to take into account the FDA categories of drugs used during pregnancy and breastfeeding. Iodine solution is a valuable formula useful for the treatment of different dermatological diseases due to its immunomodulatory features. Even actually, it is less frequent used in dermatologic prescriptions, the purpose of this article is to highlight the benefits of topical treatment with iodine solution at pregnant women with severe acne.We present the management issues raised by a severe, conglobated acne in a 29-year-old woman in 22 weeks of pregnancy with a history of vulgar acne predominantly inflammatory since 16 years of age. Systemic treatment consisted in oral clindamycin for 7 days associated with oral dexamethasone (8 mg/day). Topical treatment was represented by metronidazole B and iodine solutions and was continued after the withdraw of antibiotic and corticosteroid therapy At 30 weeks of pregnancy the acne was significantly improved and fetal biological status was normal.
Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods
Authors: Duda Seiman Daniel , Batalu Alexandra , Duda Seiman Corina , Ciopec Mihaela , Udrea Ana Maria , Motoc Marilena , Negrea Adina , Avram Speranta
Published: February 2020

Urtica dioica is a perennial plant of the family of Urticaceae, originating in Eurasia. Nettle lives in temperate regions, prefers shady places, moist soil and rich in nutrients. Worldwide nettle is considered weed. Nettle was used in the past for its medicinal properties on the body and to cure diseases such as arthritis, rheumatism, urinary tract infections, kidney stones, gingivitis, hair loss, or ulcer. It is a plant rich in nutrients, with a high content of minerals and vitamins, especially vitamin A and C. The nettle has uses in both pharmaceutical and cosmetic and nutrition processes. Nettle extract contains ursolic acid and quercetin, giving the plant antioxidant and anti-aging effects. Studies on the nettle have demonstrated a multitude of pharmacological uses including: pharmacological, antiviral, antibacterial, hepato-protective, hypotensive, diuretic and anti-inflammatory effects. The methods of extraction of the compounds used in the plant were maceration and distillation using ethanol-water-soluble solvent, used because of its extraction capacity. At the same time, the metals in the nettle were determined taking 2 samples of the root, the stalk and the nettle leaves, but also the soil from which the plant grew and were analyzed by Spectroscopy Elemental Isotope Analysis using an X-ray Fluorescence (XRF) analyzer. By cheminformatics and bioinformatics tools we elucidate for first time: (i) the drug like features and bioavailability of ursolic acid and quercetin (ii) by predictive ADMET a set of pharmacokinetic features like: absorption, distribution, metabolized, blood brain barrier and nervous system barrier crossed and toxicology features (AMES, carcinogens, hepatotoxicity, Maximum tolerated dose (human)). Our results showed that quercetin is a good candidate as antioxidant and anti-aging effects.
Dose Effect of Local Betamethasone Injection in Low Back Pain
Authors: Ahmed Abu Awwad , Prejbeanu Radu , Vermesan Dinu , Deleanu Bogdan , Ionitescu Marius , Florescu Sorin , Vlad Cristina Daliborca , Dumitrascu Victor
Published: February 2020

The purpose of the study is to show the effects and evolution of patients with back pain treated with a different dose of betamethasone, analyzing both their evolution in terms of pain perception and lifestyle. In this study, 43 patients diagnosed with back pain in the lumbar region were included over a 12-month period. Patients were divided into two categories, depending on the dose of betamethasone administered. At 1 month control after the last injection, the first group of patients, a total of 22, given the local injection of betamethasone, trigger point injection, administering the usual dose: 1 ampoule of betamethasone 1 mL + 1 ampoule 1% xyline, at the clinical examination, they claimed that pain was reduced by about 70%, sustaining the improvement of the quality of life. The same group of patients, called for the final evaluation, at 3 month, claimed the pain was reduced by about 95%, as compared to the initial pain before starting the treatment. In the second category, where 21 patients were treated by local injections, trigger point injection, administering the modified dose of betamethasone: � ampoule of betanethasone 0.5 mL + 1 ampule 1% xyline, at 1 month control after the last injection, at the clinical examination they claimed thtat the pain was reduced with just 40%, sustaining an average quality of life. Even if a low dose of betamethasone shows significantly less systemic effects, a higher dose is required in the treatment of low back pain to have the desired effect and to significantly improve the quality of life of the patient.
Memória e linguagem do cordel: o folheto popular como recurso pedagógico
Authors: Pereira Geronildo Ramos , Amorim Ivonete Barreto de
Published: February 2020

RESUMO

O artigo tem como objetivo discutir a respeito da Literatura de Cordel, apresentando suas caraterísticas, refletindo sobre seu uso como recurso pedagógico, que pode ser explorado pelos docentes na escola básica, uma vez que traz uma linguagem bastante acessível e coloquial, próxima à realidade dos estudantes, de maneira interdisciplinar, podendo também ser debatida por qualquer área, a partir das diversas temáticas presentes nessa literatura. O uso da Literatura de Cordel, em sala de aula, é muito importante, enquanto um gênero textual, no que se refere a diversos elementos, dentre eles, a linguagem, o discurso, os valores sociais, e, principalmente, no incentivo à leitura e à escrita. Traz, ainda, possibilidades de trabalho com essa arte a serem realizadas pelo docente em sua prática pedagógica, com as estrofes e as xilogravuras, sendo este interdisciplinar, podendo ser explorado com sua variedade de temas e situações de humor, comédias, fatos reais, relatos históricos, de ficção, abordando diferentes visões de mundo de acordo com o contexto e conteúdo Assim, essa discussão deixa evidente que o Cordel pode ser utilizado como recurso pedagógico para deixar as aulas mais dinâmicas, contribuindo para formação de leitores e escritores, um movimento de ensino e aprendizagem significativo, humano e contextualizado.

Palavras-chave: Literatura de Cordel. Linguagem. Prática Docente.