bluuebunny/crossref_metadata_2025 huggingface dataset:
The Interplay between KSHV Infection and DNA-Sensing Pathways
Authors: Han Chunyan , Gui Chenwu , Dong Shuhong , Lan Ke
Published: May 2024

During viral infection, the innate immune system utilizes a variety of specific intracellular sensors to detect virus-derived nucleic acids and activate a series of cellular signaling cascades that produce type I IFNs and proinflammatory cytokines and chemokines. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic double-stranded DNA virus that has been associated with a variety of human malignancies, including Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Infection with KSHV activates various DNA sensors, including cGAS, STING, IFI16, and DExD/H-box helicases. Activation of these DNA sensors induces the innate immune response to antagonize the virus. To counteract this, KSHV has developed countless strategies to evade or inhibit DNA sensing and facilitate its own infection. This review summarizes the major DNA-triggered sensing signaling pathways and details the current knowledge of DNA-sensing mechanisms involved in KSHV infection, as well as how KSHV evades antiviral signaling pathways to successfully establish latent infection and undergo lytic reactivation.
Antibody Response against SARS-CoV-2 after mRNA Vaccine in a Cohort of Hospital Healthy Workers Followed for 17 Months
Authors: Tripodi Domenico , Dominici Roberto , Sacco Davide , Pozzobon Claudia , Spiti Simona , Falbo Rosanna , Brambilla Paolo , Mascagni Paolo , Leoni Valerio
Published: May 2024

The assessment of antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of critical importance to verify the protective efficacy of available vaccines. Hospital healthcare workers play an essential role in the care and treatment of patients and were particularly at risk of contracting the SARS-CoV-2 infection during the pandemic. The vaccination protocol introduced in our hospital protected the workers and contributed to the containment of the infection’ s spread and transmission, although a reduction in vaccine efficacy against symptomatic and breakthrough infections in vaccinated individuals was observed over time. Here, we present the results of a longitudinal and prospective analysis of the anti-SARS-CoV-2 antibodies at multiple time points over a 17-month period to determine how circulating antibody levels change over time following natural infection and vaccination for SARS-CoV-2 before (T0–T4) and after the spread of the omicron variant (T5–T6), analyzing the antibody response of 232 healthy workers at the Pio XI hospital in Desio. A General Estimating Equation model indicated a significant association of the antibody response with time intervals and hospital area, independent of age and sex. Specifically, a similar pattern of antibody response was observed between the surgery and administrative departments, and a different pattern with higher peaks of average antibody response was observed in the emergency and medical departments. Furthermore, using a logistic model, we found no differences in contracting SARS-CoV-2 after the third dose based on the hospital department. Finally, analysis of antibody distribution following the spread of the omicron variant, subdividing the cohort of positive individuals into centiles, highlighted a cut-off of 550 BAU/mL and showed that subjects with antibodies below this are more susceptible to infection than those with a concentration above the established cut-off value.
Factors Associated with Vaccination Coverage among 0–59-Month-Old Children: A Multilevel Analysis of the 2020 Somaliland Demographic and Health Survey
Authors: Osman Mohamed Abdalle , Waits Alexander , Chien Li-Yin
Published: May 2024

Globally, there has been little growth in vaccination coverage, with countries in the Horn of Africa having the lowest vaccination rates. This study investigated factors associated with vaccination status among children under five years old in Somaliland. The 2020 Somaliland Demographic and Health Survey surveyed women aged 15–49 years from randomly selected households. This multilevel analysis included 2673 primary caregivers of children under five. Only 34% of children were ever vaccinated. Childhood vaccination coverage was positively associated with high-budget regions, high healthcare facility density, and children older than 23 months. Vaccination coverage was greater for urban and rural residents than for nomadic people. Children whose mothers could read part of one sentence or one complete sentence were more likely to be vaccinated than illiterate mothers. Children whose mothers received antenatal care (ANC) once, two to three times, or four times or more were more likely to be vaccinated than those whose mothers received no ANC. Childhood vaccination coverage in Somaliland is low. Promoting maternal ANC visits and increasing women’s literacy may enhance vaccination coverage. Funds should be allocated to areas with low resources, particularly for nomadic people, to boost vaccination uptake.
MivacunaLA (MyshotLA): A Community-Partnered Mobile Phone Intervention to Improve COVID-19 Vaccination Behaviors among Low-Income, Spanish-Speaking, and Immigrant Latino Parents or Caregivers
Authors: Castellon-Lopez Yelba M. , Klomhaus Alexandra M. , Garcia Cruz , Marquez Denise , Avila Hilda , Gravette Hannah , Lopez-Chang Ray , Ortega Brenda , Norris Keith C. , Brown Arleen F. , Blanco Luisa
Published: May 2024

We developed and tested MivacunaLA/MyshotLA, a community-informed mobile phone intervention, to increase COVID-19 vaccination among Latino parents/caretakers of minors in under-resourced areas of Los Angeles by addressing misinformation and building trust. We recruited Latino parents/caregivers with at least one unvaccinated child in East and South Los Angeles in the summer of 2021 and evaluated MivacunaLA as a randomized controlled trial with a wait-list control group. A difference-in-difference analysis showed Latino parents/caregivers that participated in MivacunaLA (n = 246), in comparison to the control group, were 15 percentage points more likely (p = 0.04) to report vaccination of minors aged 12–17 years, and 12 percentage points more likely (p = 0.03) to report a positive intention to vaccinate minors aged 2–11 years (when COVID-19 vaccines became available). Mobile phone-delivered digital interventions using videos and culturally tailored educational material to promote COVID-19 vaccine confidence can be an effective way to combat misinformation and deliver timely information to marginalized communities. Community-based participatory research approaches are crucial to advance health equity among minority communities, especially immigrant Spanish-speaking underserved communities.
Haematochemical Profile of Healthy Dogs Seropositive for Single or Multiple Vector-Borne Pathogens
Authors: Cocco Raffaella , Sechi Sara , Rizzo Maria , Bonomo Andrea , Arfuso Francesca , Giudice Elisabetta
Published: May 2024

Background: the present study aimed to investigate the immunological response to common vector-borne pathogens and to evaluate their impact on haematochemical parameters in owned dogs. Methods: Blood samples were collected from 400 clinically healthy dogs living in an endemic area (Sardinia Island, Italy). All dogs were serologically tested for VBDs and divided into groups based on their negative (Neg) or positive response towards Ehrlichia (Ehrl), Rickettsia (Rick), Leishmania (Leish), Borrelia (Borr), Anaplasma (Anapl), and Bartonella (Barto). A Kruskall–Wallis’s test, followed by Dunn’s post hoc comparison test, was applied to determine the statistical effect of negativity and single or multiple positivity on the studied parameters. Results: the group of dogs simultaneously presenting antibodies towards Leishmania, Ehrlichia, and Rickettsia showed higher values of total proteins, globulins, creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, and amylase than dogs that tested negative or dogs with antibodies toward a single pathogen investigated herein. Conclusions: Our results seem to suggest that exposure to more vector-borne pathogens could lead to greater liver function impairment and a greater inflammatory state. Further investigations are needed in order to better clarify how co-infections affect haematochemical patterns in dogs living in endemic areas of VBDs.
Methodology to Increase the Efficiency of the Mineral Water Extraction Process
Authors: Ilyushin Yury Valeryevich , Nosova Victoria Andreevna
Published: May 2024

The most important source of human life support is water. During the development of mineral water fields, unsustainable patterns of production and consumption have been observed, which could lead to environmental damage and the deterioration of mineral water quality and sources. In this work, a procedure for determining the modified link’s parameters, replacing the static and dynamic indicators of the hydrodynamic process, is proposed. Recording the parameters at the different filtration coefficients along the spatial coordinates allows the environmental safety of aquifers to be increased and the pressure of the reservoir to be stabilized. The presented approach allows the accuracy of the process used to control the reservoir’s pressure to be increased.
Effect of Humic Amendment on Selected Hydrophysical Properties of Sandy and Clayey Soils
Authors: Kandra Branislav , Tall Andrej , Vitková Justína , Procházka Michal , Šurda Peter
Published: May 2024

In recent years, products containing humic acids have been increasingly used in agriculture to improve soil parameters. Quantifying their impact on soil quality is, therefore, of key importance. This study seeks to evaluate the impact of the commercial humic acid product (HA) on the hydrophysical parameters of sandy and clayey soils sampled from different sites in Slovakia. Specifically, the study hypothesizes that humic amendment will enhance particle density (ρs), dry bulk density (ρd), porosity (Φ), saturated hydraulic conductivity (Ks), soil water repellency (SWR), and water retention capacity in sandy and clayey soils. The results of the laboratory measurements were analyzed using NCSS statistical software at a statistical significance of p < 0.05. In sandy soil, there was a statistically significant decrease in ρd and Ks and an increase in Φ and a contact angle (CA) after the application of 1 g/100 cm3 HA. At a dose of 6 g/100 cm3 HA, the values of ρs, ρd, and Ks decreased, and the Φ and CA values increased. In clayey soil, the Ks value significantly decreased by −35.5% only after the application of 6 g/100 cm3 HA. The addition of HA increased the full water capacity (FWC) and available water capacity (AWC) of clayey and sandy soils. The positive influence of HA on the studied soil parameters was experimentally confirmed, which can be beneficial, especially for their use in agricultural production.
Development and Applicability Evaluation of Damage Scale Analysis Techniques for Agricultural Drought
Authors: Song Youngseok , Joo Jingul , Kim Hayong , Park Moojong
Published: May 2024

In recent years, the intensity and frequency of droughts have been increasing with the advent of the climate crisis. Agricultural droughts have a significant economic and social impact. Agricultural drought is not only a natural disaster but also leads to food security threats and reduced economic activities, such as decreased productivity. Therefore, it is very important to specify the scale of agricultural drought and quantitatively estimate the economic damage. In this study, we developed an analytical methodology to quantitatively assess the economic damage of agricultural drought and estimated the damage of agricultural drought in 2018 and 2019 for the Republic of Korea. The 2018 agricultural drought was estimated to have caused USD 4.438 million in damage cost and USD 5.180 million in recovery cost. The 2019 drought was less damaging than the previous year, with an estimated damage cost of USD 286,000 and recovery costs of USD 218,000. The results suggest that the economic impact of agricultural drought varies by region depending on the frequency and intensity of the drought and confirm the importance of regional strategies for effective drought management and response. The impacts of agricultural drought go beyond short-term agricultural losses and lead to long-term economic burdens. Therefore, the results of this study are expected to be used as a basis for understanding the impacts of agricultural drought on national economies and for developing policies and strategies to minimize impacts.
Dry and Wet Spells in Poland in the Period 1966–2023
Authors: Wibig Joanna
Published: May 2024

The aim of this study is to present the spatial and temporal variability of the frequency of dry and wet days and dry and wet spells against the background of changes in precipitation and atmospheric circulation. The study is based on daily precipitation totals from 46 meteorological stations in Poland from 1966 to 2023. Additionally, seven circulation indices were used, namely GBI, NAO, AO, EA, EA/WR, SCAND, and AMO. Dry days are defined as days without precipitation. Wet days are days with at least 1 mm of precipitation. It was shown that dry spells are much more common than wet spells, are longer, and cover larger areas. Long-term changes in the annual characteristics of dry and wet days and spells are not statistically significant. Only the length of the most extended dry spell in the year increases. However, there are significant changes in their annual cycles. Spring is drier; in summer, precipitation decreases in the south and increases in the north; November and December, symbols of gloomy rainy weather, are increasingly drier; and rainy weather has shifted to January and February. The impact of circulation varies according to the season, with the NAO, AO, SCAND, and GBI indices having the greatest influence.
Mechanisms for managing investment activities in the agro-industrial complex
Authors:   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — Moscow State Agricultural Academy named after K. A. Timiryazev», Moscow, Russia, Khoruzhiy L. I. , Postnikov L. V. ,   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — Moscow State Agricultural Academy named after K. A. Timiryazev», Moscow, Russia, Lebedev K. A. ,   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — Moscow State Agricultural Academy named after K. A. Timiryazev», Moscow, Russia, Romanova A. A. ,   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — Moscow State Agricultural Academy named after K. A. Timiryazev», Moscow, Russia, Dzhikiya M. K. ,   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — Moscow State Agricultural Academy named after K. A. Timiryazev», Moscow, Russia
Published: May 2024

The relevance of the study of investment management mechanisms in the agro-industrial complex is explained by the fact that only those subjects of the agro-industrial complex that carry out active investment activities have prospects for successful functioning. However, the pace of their development is largely determined not only by the volume of investments, but also by the efficiency of their use. At the same time, the concept of «investment» reflects a complex and significant economic category. On the one hand, investments make it possible to carry out the process of agricultural production itself, and on the other, the results of the production process affect savings, that is, the possibilities of further investment. At the same time, the conducted study of the indicators of measurement and evaluation of investment projects allowed us to more fully reveal their content, objective relationships between them. At the same time, the prerequisite for calculating performance indicators was the justification of approaches that take into account objective economic laws
A Robust Examination of Cheating on Unproctored Online Exams
Authors: Fendler Richard , Beard David , Godbey Jonathan
Published: May 2024

The rapid growth of online education, especially since the pandemic, is presenting educators with numerous challenges. Chief among these is concern about academic dishonesty, especially on unproctored online exams. Students cheating on exams is not a new phenomenon. The topic has been discussed and debated within institutions of higher learning, and significant levels of cheating have been reported in the academic literature for over sixty years. Much of this literature, however, has focused on student behavior in a classroom utilizing proctored, in-class exams. Grades on exams usually determine most of a student’s final grade in a course, and GPAs are used by employers and graduate schools to indicate a student’s subject matter mastery. As more conventional colleges and universities expand their online course offerings it is natural to wonder if academic dishonesty is more prevalent in online classes than in face-to-face classes. In particular, are students more likely to cheat when no one is watching (i.e., on unproctored assessment assignments) than they do when someone is watching (i.e., on proctored assessment assignments)? The purpose of this study is to investigate whether students cheat more on unproctored online exams than they do on proctored in-classroom exams, and if so, is there any pattern to their cheating behavior. Our findings are derived from careful empirical analysis of 741 undergraduate students who completed three unproctored online exams, several collaboration-encouraged assignments, and a proctored in-class comprehensive final exam in the same course with the same instructor. Additionally, we collected demographic and human capital data for every student. Using bivariate and regression analysis, we find significant evidence of more cheating on unproctored online exams than on proctored in-class exams even though students were given stern honor code violation warnings. Moreover, we discover that student cheating increased with each unproctored online exam, implying that students learn how to cheat as they become more familiar with taking online assessment assignments. Finally, we find that students with certain demographic and human capital characteristics tend to cheat more than others. This research strongly supports the use of proctoring for all evaluation assignments in online classes to ensure that grades in these classes properly reflect student aptitude as opposed to merely reflecting their ability to cheat.
Nitrofurazone biodegradation kinetics by batch fermentation of Aspergillus tamarii
Authors: Mohamad Nur Aisyah , Zamri Muhammad Zafri , Saat Muhammad Naziz , Ariffin Zaidah Zainal
Published: May 2024

Nitrofurazone (NFZ) compound contains a 5-nitrofuran ring structure that has been widely used as feed additives in animal husbandry. Due to the benzene ring structure, the residues are highly toxic to humans and animals. A kinetics study of NFZ biodegradation in batch fermentation with Aspergillus tamarii KX610719.1 was conducted. The main objectives were to determine the kinetic parameters of fungal growth, glucose consumption, protein production, and biodegradation of NFZ using fungal biomass. Kinetic parameters were determined using Polymath 6.0 software, and regression analysis was done using linear and non-linear methods. After 168 hours of batch fermentation, the maximum specific growth rate (µmax), and maximum cell concentration (Xmax) for cultivation without NFZ were 0.062 h-1, and 0.529 g L-1, respectively. The maximum specific growth rate (µmax), and maximum cell concentration (Xmax) for cultivation with NFZ were 0.092 h-1, and 0.327 g L-1, respectively. For glucose consumption, kinetic parameters of Yield of biomass over the substrate (YXS) and cell maintenance (mS) were estimated at 0.139 g g-1 and 0.239 h-1, respectively. Based on the Luedeking Piret model, the estimated growth-associated (α) and non-growth-associated (β) constants were 1.142×10-2 g g-1 and 5.680×10-5 h-1, respectively. The rate constant (k1) of NFZ biodegradation was estimated at 2.696×10-2 h-1 following the first-order model where the rate constant of NFZ removal is dependent on the NFZ concentration. The application of A. tamarii batch fermentation in the removal of NFZ compound was sufficient with a total percentage removal of 85.9 % or 0.430 g L-1 recorded.
ON THE IDENTIFICATION OF THE TIC INTERLAY IN THE DIFFUSION ZONE OF THE SMIC OF THE TI-FE SYSTEM
Authors:   Volgograd State Technical University, SHMORGUN V.G. , SLAUTIN O.V. ,   Volgograd State Technical University, KULEVICH V.P. ,   Volgograd State Technical University, KHARLAMOV V.O. ,   Volgograd State Technical University, BOGDANOV A.I. ,   Volgograd State Technical University
Published: May 2024

The paper presents the data of electron-optical studies on the identification of the TiC interlayer in the composition of the diffusion zone, which is formed at the interlayer boundary in the SMIC of the Ti - Fe system after diffusion annealing.
INVESTIGATION WELDED COPPER-STEEL BIMETAL AFTER BENDING
Authors:   Volgograd State Technical University, ARISOVA V.N. , GUREVICH L.M. ,   Volgograd State Technical University, GOLIKOVA A.P. ,   Volgograd State Technical University, SEMENOVA V.S. ,   Volgograd State Technical University
Published: May 2024

It is shown that for explosion-welded bimetal M3 copper with 30CrMnSiA steel, technological stages accompanied by significant bending deformations after annealing at a temperature of 880 °C and a holding time of 1 hour are shown. It has been established that a three-point bending with a 20 mm knife to a degree of deformation in copper of 23-26 %, and in steel of 10-11 % does not lead to the appearance of cracks in the components of the composite.
La calidad de la educación en el ámbito rural: Una revisión sistemática 2017 – 2023
Authors: Mendoza-Ponce Franclin Wildor
Published: May 2024

En este artículo se planteó como propósito una exploración de la literatura sobre la educación rural en el Perú y en otras naciones para analizar y discutir de manera reflexiva sobre la calidad de la educación en el ámbito de la ruralidad. Para tal efecto, se utilizó el método del análisis documental, cuyo procedimiento investigativo permitió acceder a bases de datos de prestigio como Scielo y Redalyc, mediante la sistematización de 12 artículos. Los resultados demuestran que aún existen brechas insalvables entre la educación urbana y la educación rural, dadas las desacertadas políticas educativas tanto en el Perú como en otros países, de lo cual se concluye que existe la imperiosa necesidad de proponer alternativas que respondan a las necesidades de los pobladores en la zona rural, así como a la revaloración de la cultura y las costumbres de los pueblos por parte de las organizaciones promotoras nacionales e internacionales
A importância do ambiente urbano para o bem-estar: Análise em Lisboa – Portugal - utilizando redes sociais
Authors: Betco Iuria , Rocha Jorge
Published: May 2024

Os problemas de saúde mental têm vindo a aumentar em todo o mundo, o que poderá estar associado ao crescimento da população urbana e ao estilo de vida a ela associado. O reconhecimento de que os diversos aspetos do ambiente ur-bano podem afetar a saúde mental dos indivíduos tem vindo a aumentar, uma vez que, estes são responsáveis por facilitar ou inibir comportamentos e estilos de vida que impactam o sentimento. Neste contexto é importante compreender o potencial impacte do ambiente urbano da cidade de Lisboa. Para tal recorreu-se à análise de sentimentos, utilizado um léxico do NRC Sentiment and Emotion, a partir de dados da rede social Twitter, possibilitando a identificação dos locais em que tanto o sentimento positivo como negativo prevalecem. De seguida fez-se uso de um modelo de machine learning (ML) associado a um modelo-agnóstico de modo a aumentar a compreensão dos fatores do ambiente urbano que podem explicar o sentimento. Foram testados 4 modelos de ML, Random Forest (RF), Ex-treme Gradient Boosting (XGBoost), Neural Network (NN), o K-Nearest Neighbour (KNN) e um modelo linear para comparação (Generalized Linear Model - GLM). Os modelos agnósticos aplicados, o Local Interpretable Model-Agnostic Explanations (LIME) e o SHapley Additive exPlanation (SHAP), desempenharam um papel funda-mental neste estudo. Respondendo à questão de partida, as variáveis explicativas que mais se relacionam com o sentimento são a distância a equipamentos fitness, a distância aos espaços verdes, a popularidade dos locais (estimada através da rede social Flickr) e a distância à rede ciclável.
Combining Dialog Acts and Skill Modeling: What Chat Interactions Enhance Learning Rates During AI-Supported Peer Tutoring?
Authors: Borchers Conrad , Yang Kexin , Lin Jionghao , Rummel Nikol , Koedinger Kenneth R. , Aleven Vincent
Published: May 2024

Peer tutoring can improve learning by prompting learners to reflect. To assess whether peer interactions are conducive to learning and provide peer tutoring support accordingly, what tutorial dialog types relate to student learning most? Advancements in collaborative learning analytics allow for merging machine learning-based dialog act classification with cognitive modeling of fine-grained learning processes during problem-solving to illuminate this question. We estimate how much peer-tutored students improve in a collaborative tutoring system for linear equation-solving in K-12 mathematics in relationship to the peer dialog types they engage in. This work establishes a reliable BERT classifier with an accuracy of close to 80\% to classify chat messages during peer tutoring into minimal, facilitative, and constructive, serving as instructional factors. Based on data from 394 students, peer tutor dialog was rare. Only 8\% of tutee problem-solving steps were followed by peer tutor chat messages. Still, facilitative tutor dialog was associated with an increased tutee learning rate. Meanwhile, tutor dialog classified as constructive was associated with lower learning rates. Content analysis suggested that such dialog often reinforced incorrect solutions, gave away answers, or was unrelated to the taught content. Hence, considering problem-solving solution contexts could improve the assessment of peer tutoring dialog. Peer tutors engaging in little dialog could be attributed to the high cognitive demand of learning to tutor while still learning the content they tutor on. Providing peer tutors with instructional support to engage in constructive dialog may improve the tutee's learning.
USING SOLAR ENERGY AS NON-CONVENTIONAL ALTERNATIVE ENERGY IN SMALL AND MEDIUM-SIZED FARMS
Authors: CRISTEA Mario , VLĂDUȚ Nicolae-Valentin , UNGUREANU Nicoleta
Published: May 2024

Solar energy represents a future solution for clean, sustainable energy, because the sun generates much more energy every day than it is necessary for daily consumption, unlike fossil fuels. The only limitation related to this renewable resource is the ability to transform this energy into electricity. The paper presents a functional model of equipment that allows the capture of solar energy using special panels, which can rotate according to the sun, so that the incidence of rays with the radiating surface of the panels is maximum, and the yields obtained at different angles of inclination (in the vertical plane: 30 and 45, and in the horizontal plane: 0 to be maximum.
DESIGN AND MECHANISM STUDY OF SEED FILLING ROOM WITH STAGGERED ORIENTED PLATES AND VIBRATION
Authors: MO Zhiye , LU Fangyuan , ZHANG Mengqi , TAO Chong , WANG Bolong , ZHANG Guohai , MA Xu
Published: May 2024

Aiming at the existing rice mechanized seeding technology it is difficult to meet the hybrid rice low seeding volume precision seeding requirements. In this paper, based on the friction characteristics of rice seed and the theory of silo arching, the structure and parameters of seed filling room with staggered oriented plates and vibration in the quantitative seed supply device were designed. EDEM software was used to simulate the working process of the quantitative seed supply device, and it was determined that staggered oriented plates structure in the seed filling room combined with vibration could effectively prevent seed arching, thus improving the uniformity of seed supply. Finally, the results of the simulation analysis were verified by rice quantitative seed supply test. The results showed that the vibration could increase the seed supply frequency by 3.64% for large sowing weight of conventional rice and 5.52% for small sowing weight of hybrid rice. In addition, the analysis of the coefficient of variation of the seed supply frequency by quantitative seed supply devices showed that the vibration effect could increase the stability of seed supply device by 2.47 % for the conventional rice seed and 1.33 % for the hybrid rice seed, which increased the seed supply stability.
FAKTOR-FAKTOR YANG BERHUBUNGAN TERJADINYA LASERASI PERINIUM PADA SAAT PERSALINAN
Authors: Florentina Kusyanti Floren , Putri Kornelia , Anisah Anisah
Published: May 2024

Latar Belakang: Periode Kehamilan dan persalinan adalah sangat berhubungan dengan kehidupan seorang Wanita.Persalinan adalah proses yang sangat memerlukan pendampingan,pengawasan sehingga proses persalinan ini bisa berjalan normal.Persalinan adalah suatu proses pengeluaran hasil konsepsi dari suatu pasangan suami istri,Dimana proses ini harus diperlukan pengawasan dan pendampingan,untuk menjaga agar saat persalinan perinium tetap utuh maka ada beberapa usaha dari pasien dan bidan,selain itu laserasi perinium juga banyak factor yang mempengaruhinya. Tujuan untuk mengetahui factor yang bisa berhubungan terjadi laserasi perinium pada saat persalinan.Metode: Penelitian ini dilaksanakan di PMB Kuswatiningsih ,Desain yang dipakai pasa penelilian ini adalah kuantitatif dengan pendekatan cros sectional .Tehnik pengumpulan data dengan Total sampling, Sampling jumlah sampel 125 responden .Data diambil pada pasien yang melahirkan di PMB Kuswatiningsih mulai bulan Januari 2023 sampai bulan Juli 2023.Hasil: Jumlah 125 responden,responden adalah semua ibu yang melahirkan mulai bulan januari sampai bulan juli 2023,karakteristik responden umur 26-35 sebesar 55,2%,Pendidikan menegah 61,6%,Pekerjaan IRT 51,2%,paritas anak 1 yaitu 43,2%,tinggi badan 151-155 sebesar 42,4%.Faktor lain laserasi  derajat 2 dan  diheating sebesar 82,4%,BBL lebih 3000 gram sebesar 52,8%.hubungan antara paritas dengan laserasi derajat 2 sebesar 92,5%,BBL > 3000 gram dengan laserasi derajat 2 sebesar 83,3%,Tinggi badan dengan laserasi pada TB 151-155 terjadi laserasi derajat 2 sebesar 84,9%Kesimpulan: ada hubungan antara paritas dengan laserasi,ada hubungan antara BBL dengan laserasi.
PENGARUH PENERAPAN TERAPI MEDITASI MUSIK RELIGIUS TERHADAP PENURUNAN TEKANAN DARAH PADA PENDERITA HIPERTENSI LANJUT USIA DI POSYANDU LANSIA DESA TAMBAKSELO
Authors: Riniasih Wahyu , Utami Putri Madina
Published: May 2024

Latar Belakang: penyakit tidak menular (PTM) yang semakin meningkat salah satunya yaitu hipertensi. Menurut dinkes kab. Grobogan Presentase di daerah pedesaan (38,11%) > perkotaan (37,01%) Data yang diambil pada 1 febuari 2023 Prevalensi hipertensi lansia di posyandu lansia desa Tambakselo sebesar 27% penderita hipertensi. Meditasi musik religius menghantarkan partikel yang disebut nitrik oksida di pembuluh darah yang berfungsi mengendurkan otot polos pembuluh darah dan berperan dalam mengatur aliran darah melalui jaringan dan menjaga tekanan peredaran darah di dalam batas normal.Metodologi: Penelitian ini merupakan penelitian kuantitatif menggunakan quisy Eksperiment dan desain  pretest and posttest with control grup design, Teknik sempling yang digunakan adalah random Sampling dengan 38 responden.Hasil: Berdasarkan SPSS menggunakan Uji Paired Sample T Test.didapatkan nilai p value 0.000 dikarenakan <0.05 maka dapat disimpulkan Ha diterima Ho ditolak. Sehingga dapat disimpulkan ada Pengaruh penerapan terapi meditasi musik religius terhadap penurunan tekanan darah pada penderita hipertensi lanjut usia diposyandu lansia desa Tambakselo.Kesimpulan: Berdasarkan dari penelitian ada Pengaruh penerapan terapi meditasi musik religius terhadap penurunan tekanan darah pada penderita hipertensi lanjut usia diposyandu lansia desa Tambakselo.Kata Kunci: Meditasi musik religius, tekanan darah, HipertensiKepustakaan: 41 (2016-2022)
STOCHASTIC MODEL FOR PREDICTING THE EVOLUTION OF ELECTRIC VEHICLES IN EGYPT AND THEIR IMPACT ON ENERGY AND THE ENVIRONMENT UP TO 2040
Authors: Khass Tarek , Ragab Reda , El Salmawy Hafez A. , Ismail Mohamed A.
Published: May 2024

The transportation sector in Egypt consumes 22% of the total hydrocarbon consumed in the country. As the power generation sector is shifting toward renewable energy, electrification of the transport sector will represent an effective tool to reduce greenhouse gasses. This study aims to assess the environmental and economic consequences of the evolution of the share of electric vehicles (EVs) in private car and taxi fleets in Egypt up to 2040. A detailed stochastic model was developed to calculate the total cost of ownership for both electric and conventional gasoline vehicles using a bottom-up stochastic approach. The model predicts the evolution of EVs in the Egyptian market up to 2040 and assesses the environmental and economic consequences of the conversion to EVs. In addition, the model considers the statistical distribution of new cars among various car classes, developing a database for the equivalent sizes of EVs and their prices. Base and proactive scenarios predicted the required energy policies to facilitate the transition to electric mobility in both scenarios. Based on the model, the share of electric private cars and taxis will reach 26.7% and 48.1% of the total quantity of vehicles by 2040. Gasoline saving up to 2.85 Mt will be a 10.81 Mt reduction in CO2 emissions up to 2040. The EV electricity demand for the proactive scenario will be 12.9 TWh by 2040. This demand represents a share of 2.2%–3.65% of the electricity generated by 2040, depending on the base and proactive scenarios, respectively. However, it may be a challenge at the electricity distribution level. This request enhances the distribution infrastructure and incorporates smart charging and optimization techniques.
Mitos y verdades de la radioterapia. Breve revisión y guía práctica dirigida a médicos egresados, estudiantes de pregrado de la Facultad de Medicina y estudiantes de tecnicatura de radioterapia: preguntas y respuestas
Authors: Ferrer Criado Joaquin Carlos , Moran Ramos Victoria , Rosich Agustin , Ochandorena Karina , Lorenzo Federico
Published: May 2024

Introducción: los pacientes concurren habitualmente a la consulta preguntando por los posibles efectos tóxicos del tratamiento oncológico radiante sobre los tejidos normales. Esta breve revisión bibliográfica en formato de preguntas y respuestas, presenta mediante la evidencia científica y la medicina basada en la evidencia, algunas de las preguntas con las que se encuentra el médico que trata o interactúa con un paciente con cáncer. El objetivo de esta revisión es apoyar en la respuesta que dará el médico general, oncólogo médico, físico médico y tecnólogos en radioterapia a esas interrogantes.
Metodología: se realizó una búsqueda bibliográfica no sistemática en Google Scholar, MedLine/PubMed y Scielo limitando a trabajos publicados en los últimos 10 años.
Resultados: tras consultas con profesionales directamente relacionados con la radioterapia, se identificaron las dudas recurrentes planteadas por los pacientes.
Discusión: con la información recopilada se dan respuesta a las interrogantes más frecuentes establecidas previamente.
Recibido para evaluación: noviembre 2023.
Aceptado para publicación: enero 2024.
Correspondencia: Diego Lamas 1357, apto. 104. Montevideo, Uruguay. Tel. +598 099682258.
E-mail de contacto: jferrercriado@gmail.com
Este artículo fue aprobado por el Comité Editorial.
LAVAGEM DE DINHEIRO E O DIREITO PENAL BRASILEIRO
Authors: Rocha Rafael , Valle Luciano do
Published: May 2024

Este estudo tem por objetivo analisar a criminalização da lavagem de dinheiro no Brasil, abordando seu histórico, os dispositivos legais vigentes e os desafios enfrentados pelo sistema jurídico e financeiro, a pesquisa investiga a eficácia das políticas de combate, os desafios atuais, as implicações das evoluções legislativas e os julgados do Supremo Tribunal Federal. Utilizando uma metodologia qualitativa, pautada na análise bibliográfica e documental, a pesquisa examinou leis, regulamentações e decisões judiciais relevantes. Os resultados destacam a complexidade da questão, ressaltando a necessidade de uma abordagem multifacetada e colaborativa para enfrentar o problema da lavagem de dinheiro no Brasil, assim sendo, é essencial continuar aprimorando as leis, políticas e práticas de combate à lavagem de dinheiro, visando proteger o sistema financeiro, a integridade do país e a segurança pública.
ANALISIS EFEKTIVITAS BIAYA (Cost Effectiveness Analysis) PENGGUNAAN ANTIPSIKOTIK MONOTERAPI ATIPIKAL DENGAN KOMBINASI ATIPIKAL DAN TIPIKAL PADA PASIEN RAWAT INAP SKIZOFRENIA DI RUMAH SAKIT JIWA GRHASIA YOGYAKARTA
Authors:   Universitas Alma Ata, Afitriyani Novi , Dwinta Eliza ,   Program Studi Sarjana Farmasi, Fakultas Ilmu-Ilmu Kesehatan Universitas Alma Ata, Putri Imram Radne Rimba ,   Program Studi Administrasi Rumah Sakit, Fakultas Ilmu-Ilmu Kesehatan Universitas Alma Ata, Astuti Witri Susila ,   Instalasi Farmasi, Rumah Sakit Daerah Panembahan Senopati Bantul, Daerah Istimewa Yogyakarta
Published: May 2024

Schizophrenia is a serious mental disorder characterized by impaired thinking, hallucinations and social behavior. Yogyakarta Special Region (DIY) ranks 2nd with a prevalence of schizophrenia reaching 10.4 per 1,000 population. The high number of people suffering from mental disorders can lead to increasingly expensive costs. To reduce the problem of health financing, a cost-effectiveness analysis is needed by calculating the cost of antipsychotic drugs and calculating the Average Cost Effectiveness Ratio value. The aim of this study was to determine the cost-effectiveness of using atypical antipsychotic monotherapy with atypical and typical combinations in schizophrenia patients at RSJ Grhasia Yogyakarta. The research method was carried out descriptively and retrospectively using medical record data for the period January-December 2022, with a proportional sampling technique. Results: research shows that atypical monotherapy antipsychotics are more cost-effective with an Average Cost Effectiveness Ratio value of IDR 204.4/week of therapeutic treatment compared to atypical-typical combination antipsychotics with a greater value of IDR 343.2/week of therapeutic treatment. Conclusion: The antipsychotics used by inpatient schizophrenia patients at RSJ Grhasia Yogyakarta had the highest effectiveness, namely in the atypical monotherapy therapy group, amounting to (93.02%).
Contexto brasileiro da Doença de Chagas: Perspectivas atuais sobre epidemiologia, vetores e diagnóstico
Authors: Matos Daniele da Costa , Ost André Felipe Nunes , Neto João Plácido Dodô , Sousa Leticia Bastos de , Silva Vicctórya Emmanuely Gomes Santos , Oliveira Genecy Andrade de , Taino Rafaela Monique Giacon , Ferraz Luis Felipe Galetti , Peixoto Régis de Oliveira , Canuto Thaisa Andressa Floriano , Dutra Aline Soares de Santana , Vasconcelos Thays Roberta da Silva , Gonçalves Roberta , Souza Isadora Luiza Babinschi Dias de , Pereira-Silva Jordam William , Amaral Luana Afonso do
Published: May 2024

Este estudo discorre sobre os dados epidemiológicos mais recentes da doença de Chagas no Brasil, conforme apresentados no Boletim Epidemiológico do Ministério da Saúde de abril de 2022. Os resultados revelam uma ampla gama de informações, desde a prevalência da doença em diferentes regiões do país até os índices de vulnerabilidade. Notavelmente, há variações significativas nos indicadores entre estados e macrorregiões de saúde. Além disso, os dados destacam desafios no controle da doença, como a necessidade de intensificar as ações preventivas e de vigilância em áreas mais vulneráveis. Compreender esses padrões epidemiológicos é crucial para orientar políticas públicas direcionadas e estratégias de intervenção, visando reduzir a transmissão da doença e mitigar seus impactos na saúde pública. Essa análise aprofundada dos dados epidemiológicos fornece uma base sólida para o desenvolvimento de medidas eficazes de prevenção, diagnóstico e tratamento da doença de Chagas, contribuindo assim para o avanço no controle dessa enfermidade no Brasil.
Avaliação in vitro da microinfiltração marginal de dois materiais restauradores em cavidades classe III
Authors: Mioranza Vivan Débora , Piardi Rafaela , Cortina Bellan Mariá , Bruzza Adriano , Bonezi Boff Luiza , Conde Alexandre , Galafassi Daniel , Pereira Butze Juliane , Paulus Marília
Published: May 2024

Os materiais restauradores têm se destacado na clínica odontológica, bem como os cimentos de ionômero de vidro, onde suas propriedades permitem que este material seja utilizado como restaurador, forrador e agente cimentante, pois é um material que apresenta propriedades como adesão à estrutura dentária. O presente estudo in vitro avaliou a microinfiltração marginal em cavidades classe III em coroas de dentes bovinos, restaurados com dois tipos de materiais restauradores: Cention N e Vitro Fil LC, através da avaliação da penetração de um corante fucsina violeta. Os resultados foram analisados através do teste de qui-quadrado, com nível de significância de 5% (P>0,708) concluindo que não há significância clínica entre os materiais restauradores.
MECANIZAÇÃO DA INSTRUMENTAÇÃO ENDODÔNTICA: REVISÃO DE LITERATURA
Authors: Francisco Nathizael Ribeiro Gonçalves  , Monalisa Simplício Bezerra  , Matheus Lopes Carvalho  , Edla Helena Salles de Brito  , Ravel Bezerra Brasileiro  , Mariana Canuto Melo de Sousa Lopes  , Matheus de Sousa Aguiar  , Isabela Brito Freitas  , Ranyele Elis Alexandre Rodrigues  , Marcela Maria Costa Borges  , Amanda Brito Santos  , Ana Letícia Linhares De Sousa Paula  , Diego Gibson Praxedes Martins
Published: May 2024

A Endodontia é uma especialidade crucial na odontologia, centrada na prevenção e tratamento das condições que afetam a polpa e os tecidos ao redor do dente. Nos últimos tempos, avanços significativos têm sido alcançados, especialmente com a introdução de instrumentação mecanizada, como as limas de Níquel-Titânio (NiTi), marcando uma nova era na Endodontia. Este estudo tem como objetivo realizar uma revisão abrangente sobre a evolução, benefícios e limitações da Endodontia mecanizada na prática odontológica contemporânea. Foram examinados 31 estudos que exploraram o uso de instrumentação mecanizada em procedimentos endodônticos, comparando diferentes abordagens de instrumentação manual, rotatória e reciprocante dos canais radiculares. Os resultados destacam as vantagens substanciais da Endodontia mecanizada, incluindo redução do tempo de trabalho, eficácia na remoção de detritos e microrganismos, e precisão aprimorada. No entanto, desafios como custos elevados e necessidade de treinamento especializado persistem. A Endodontia mecanizada representa uma promissora fronteira na busca por tratamentos mais eficientes, beneficiando tanto pacientes quanto profissionais da odontologia.
Population migration as a subject scientific search in regional science (on the example of research in the republic of Sakha (Yakutia))
Authors: Barashkova А. S. , Neustroeva А. B.
Published: May 2024

The purpose of the work is to reveal the migration topics of research in Yakutia, where the migration factor has played and plays an important role in the formation of the population. The analysis is carried out on a large array of literary sources, covers the pre-Soviet, Soviet and post- Soviet periods. It is shown that in the first two periods, the historical, geographical, and partly economic aspects of the migration process were more studied. The range of post-Soviet studies has expanded with demographic and sociological studies.
Ontological foundations of spirituality and civic service in modern domestic culture
Authors: Miller V. I. , Duminskaya М. V.
Published: May 2024

The modern socio-cultural situation indicates the unfolding of another round of the stage of spirituality as the inability of a person to demonstrate an active civic position, namely to benefit society; in the loss of the value of spiritual quest for meaning and life issues, and as a result - it is the leveling of the value of human personality. The process of forming the spiritual potential of the individual for a long time was not realized as a personal or social need.
The image of Russia in the works of A.I. Solzhenitsyn (based on the material of journalism and the epic “Red Wheel”)
Authors: Makarchuk I. Yu.
Published: May 2024

A.I. Solzhenitsyn's portrayal of Russia in his journalistic works and the epic "The Red Wheel" is distinguished not only by patriotism, loyalty to national cultural traditions, but also by the desire for an objective and reliable positioning of his Fatherland. For the writer, Russia is a huge, unyielding and great country with its own distinctive path of development, centuries‒old reliance on Christian values.
Social and cultural factors of students' health in the conditions of the northern region
Authors: Bagnetova E. A. , Vitvitsky P. A.
Published: May 2024

The educational process of students of the Khanty-Mansiysk Autonomous Okrug- Yugra takes place in difficult climatic, geographical and environmental conditions, when the very fact of living in the northern region indicates the presence of increased health risks. This problem actualizes the task of forming a healthy lifestyle and fostering a culture of health, since these two factors are the leading ones in maintaining health. The purpose of the study was to assess the behavioral risk factors and health culture of students, taking into account the regional characteristics of residence.
On the significance of D.S. Likhachev's legacy in the implementation of civic and moral education in an educational institution (from work experience)
Authors: Dombrovskaya I. V.
Published: May 2024

The article adresses the issues of the development of civic and moral education of students in educational institution on the example of using publicistic and scientific works of D.S. Likhachev; analysis of the components of civic and moral education of schoolchildren; approaches to the implementation of the main tasks of education in school are considered; the experience of practical implementation of educational tasks in educational institution is presented.
Professional training through participation in competitive activities
Authors: Savelieva N. N.
Published: May 2024

The article examines the competitive activity of students as a way of forming and developing professional and supra-professional competencies. The authors hypothesize that the active participation of students in engineering championships and technological entrepreneurship competitions contributes to the quality training of professionals. A pedagogical experiment was organized: the control group studied according to the traditional curriculum, students in the experimental group, in addition to the main training, participated in technological entrepreneurship competitions and engineering championships. Students in the experimental group, after participating in various competitions, increased the level of developed professional and supra-professional competencies and the quality of professionalism upon leaving the university.
Case studies as a means of developing students’ financial literacy
Authors: Belokurova E. V. , Gorlova S. N. , Kovalenko A. A.
Published: May 2024

The transformation of school mathematics education is invariably determined by the changes occurring in modern society. From the standpoint of understanding school education in the context of the continuous accumulation and integration of life skills and abilities, this paper substantiates the possibility and feasibility of using case technology in teaching mathematics.