bluuebunny/crossref_metadata_2025 huggingface dataset:
Complementary Feature Pyramid Network for Object Detection
Authors: Xie Jin , Pang Yanwei , Pan Jing , Nie Jing , Cao Jiale , Han Jungong
Published: February 2023

The way of constructing a robust feature pyramid is crucial for object detection. However, existing feature pyramid methods, which aggregate multi-level features by using element-wise sum or concatenation, are inefficient to construct a robust feature pyramid. The reason is that these methods cannot be effective in discriminating the relevant semantics of objects. In this article, we propose a Complementary Feature Pyramid Network (CFPN) to aggregate multi-level features selectively and efficiently by exploring complementary information between multi-level features. Specifically, a Spatial Complementary Module (SCM) and a Channel Complementary Module (CCM) are designed and embedded in CFPN to enhance useful information and suppress irrelevant information during feature fusions along spatial and channel dimensions, respectively. CFPN is a generic feature extractor, as evidenced by its seamless integration into single-stage, two-stage, and end-to-end object detectors. Experiments conducted on the COCO and Pascal VOC datasets demonstrate that integrating our CFPN into RetinaNet, Faster RCNN, Cascade RCNN, and Sparse RCNN obtains consistent performance improvements with negligible overheads. Code and models are available at:
https://github.com/VIPLab-CQU/CFPN
.
Applying Technology in a Hybrid-Fashion to Create Dementia-Inclusive Community Spaces
Authors: Czech Elaine
Published: February 2023

While there is currently no cure for dementia, socially prescribing activities can enhance wellbeing for people living with dementia (PLWD). However, accessibility to such activities can be hindered by location, being unaware of activities, scheduling issues, or lack of interest in the specific activity. The COVID-19 pandemic further complicated accessibility and changed how coordinators of such programs thought about technology. This PhD research explores how technology can improve accessibility to community spaces and programs for PLWD and their informal carers. The first study involved understanding how technology used for social programs changed during the pandemic and developing guidelines for how program coordinators and technologists can adapt and develop technology for disseminating social programs. The current study aims to discover what elements may be necessary for spaces and programs to feel accessible for PLWD and how these elements can be translated or manifested through technology.
A Review of Indigenous Perspectives in Animal Biosciences
Authors: John Kelsey Dayle , John Gilbert H.
Published: February 2023

This article addresses the underrepresentation of Indigenous perspectives in animal sciences by challenging the exclusive use of Western scientific paradigms in research and education. Because of the systematic exclusion of Indigenous peoples, Indigenous perspectives have rarely been represented through empirical study, leading us to believe this is a key reason for the underrepresentation of Native people in these fields. We conducted a literature review, searching for Indigenous contributions in animal sciences and finding a handful of articles in three areas: human–animal bonds, genetic testing and breeding programs, and Traditional Ecological Knowledge. Given the interconnected paradigm of Indigenous worldviews, we suggest that the ongoing siloes of scientific disciplines and the hierarchy of methodology contribute to the dearth of Indigenous perspectives. We suggest increased support for proper tribal consultation, contextualization of the history of research in Native communities, and the creation of scholarly spaces to support these conversations.
Developmental Consequences of Intimate Partner Violence on Children
Authors: Bogat G. Anne , Levendosky Alytia A. , Cochran Kara
Published: February 2023

Numerous studies associate childhood exposure to intimate partner violence (IPV) with adverse adjustment in the domains of mental health, social, and academic functioning. This review synthesizes this literature and highlights the critical role of child self-regulation in mediating children's adjustment outcomes. We discuss major methodological problems of the field, including failure to consider the effects of prenatal IPV exposure and the limitations of variable-oriented and cross-sectional approaches. Finally, we present a comprehensive theoretical model of the effects of IPV on children's development. This model includes three mechanistic pathways—one that is unique to IPV (maternal representations) and two that are consistent with the effects of other stressors (maternal mental health and physiological functioning). In our model, the effects of these three pathways on child adjustment outcomes are mediated through parenting and child self-regulation. Future research directions and clinical implications are discussed in the context of the model.
Dietary fiber intake and fecal short-chain fatty acid concentrations are associated with lower plasma lipopolysaccharide-binding protein and inflammation
Authors: Bailey Melisa A. , Thompson Sharon V. , Mysonhimer Annemarie R. , Bennett Jessica N. , Vanhie James J. , De Lisio Michael , Burd Nicholas A. , Khan Naiman A. , Holscher Hannah D.
Published: February 2023

Dietary fiber intake may reduce the inflammation associated with obesity and metabolic disease. Our cross-sectional analysis revealed that dietary fiber intake and fecal short-chain fatty acids are inversely associated with lipopolysaccharide-binding protein, a marker of systemic inflammation. In addition, plasma interleukin-6 and C-reactive protein were positively related to markers of adiposity.
FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells
Authors: Danopoulos Soula , Belgacemi Randa , Hein Renee F. C. , Miller Alyssa J. , Deutsch Gail H. , Glass Ian , Spence Jason R. , Al Alam Denise
Published: February 2023

Fibroblast growth factor (FGF) signaling is known to play an important role in lung organogenesis. However, we recently demonstrated that FGF10 fails to induce branching in human fetal lungs as is observed in mouse. Our previous human fetal lung RNA sequencing data exhibited increased FGF18 during the pseudoglandular stage of development, suggestive of its importance in human lung branching morphogenesis. Whereas it has been previously reported that FGF18 is critical during alveologenesis, few studies have described its implication in lung branching, specifically in human. Therefore, we aimed to determine the role of FGF18 in human lung branching morphogenesis. Human fetal lung explants within the pseudoglandular stage of development were treated with recombinant human FGF18 in air-liquid interface culture. Explants were analyzed grossly to assess differences in branching pattern, as well as at the cellular and molecular levels. FGF18 treatment promoted branching in explant cultures and demonstrated increased epithelial proliferation as well as maintenance of the double positive SOX2/SOX9 distal bud progenitor cells, confirming its role in human lung branching morphogenesis. In addition, FGF18 treated explants displayed increased expression of SOX9, FN1, and COL2A1 within the mesenchyme, all factors that are important to chondrocyte differentiation. In humans, cartilaginous airways extend deep into the lung up to the 12th generation of branching whereas in mouse these are restricted to the trachea and main bronchi. Therefore, our data suggest that FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells.
Biomarkers for rapid H-reflex operant conditioning among females
Authors: Johnson Kristin A. , Petrie Michael A. , Shields Richard K.
Published: February 2023

Young females who acutely increase their H-reflexes with operant conditioning had lower levels of estradiol. However, the best predictors of those who could up-train the H-reflex were baseline H-reflex excitability (H-max/M-max) and extracellular to intracellular water ratio (ECW/ICW). Future studies are warranted to understand the complex relationship between operant conditioning, human performance, and injury among active young females.
Traffic Safety Oriented Multi-Intersection Flow Prediction Based on Transformer and CNN
Authors: Fu Tingting , Yu Qianwen , Lao Haksrun , Liu Peng , Wan Shaohua
Published: February 2023

Intelligent traffic signal control is one of the important means to ensure traffic safety. Effective signal control can make traffic flow fast and smooth, which first needs current and future traffic information. As the control of one intersection may affect adjacent intersections, this paper proposes to predict future traffic flow with consideration of multi-intersections. It can dynamically improve traffic conditions and reduce traffic congestion. Based on various nonlinear spatial relationships at correlated multi-intersections and the potential time-dependent relationship in traffic volume, a traffic flow prediction method named CNNformer which combines transformer with CNN, is proposed. The convolution neural network (CNN) and transformer are used to extract the spatial and temporal features of correlated multiple intersections. The learnable time code is embedded into transformer’s location code, and the location information and time information are injected into the model to help it learn the time characteristics of traffic volume. This study also considers the impact of cyclical traffic flow pattern and proposes CNNformer+. In the method, all of the data from the previous time window, as well as the data from the prior week and month, are correspondingly entered into the network. Finally, the output is generated through average pooling, realizing the learning of cyclical traffic flow characteristics. In the experiment, CNNformer+ and the state-of-the-art traffic flow prediction methods are compared using simulated data. The results show that the proposed model outperforms the existing models in prediction accuracy and efficiency.
Study on the Mechanism of Qing‐Fei‐Shen‐Shi Decoction on Asthma Based on Integrated 16S rRNA Sequencing and Untargeted Metabolomics
Authors: Hu Haibo , Zhao Guojing , Wang Kun , Han Ping , Ye Haiyan , Wang Fengchan , Liu Na , Zhou Peixia , Lu Xuechao , Zhou Zhaoshan , Cui Huantian
Published: February 2023

Qing‐Fei‐Shen‐Shi decoction (QFSS) consists of Prunus armeniaca L., Gypsum Fibrosum, Smilax glabra Roxb., Coix lacryma-jobi L., Benincasa hispida (Thunb.) Cogn., Plantago asiatica L., Pyrrosia lingua (Thunb.) Farw., Houttuynia cordata Thunb., Fritillaria thunbergii Miq., Cicadae Periostracum, and Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle. QFSS shows significant clinical efficacy in the treatment of asthma. However, the specific mechanism of QFSS on asthma remains unclear. Recently, multiomics techniques are widely used in elucidating the mechanisms of Chinese herbal formulas. The use of multiomics techniques can better illuminate the multicomponents and multitargets of Chinese herbal formulas. In this study, ovalbumin (OVA) was first employed to induce an asthmatic mouse model, followed by a gavage of QFSS. First, we evaluated the therapeutic effects of QFSS on the asthmatic model mice. Second, we investigated the mechanism of QFSS in treating asthma by using an integrated 16S rRNA sequencing technology and untargeted metabolomics. Our results showed that QFSS treatment ameliorated asthma in mice. In addition, QFSS treatment affected the relative abundances of gut microbiota including Lactobacillus, Dubosiella, Lachnospiraceae_NK4A136_group, and Helicobacter. Untargeted metabolomics results showed that QFSS treatment regulated the metabolites such as 2‐(acetylamino)‐3‐[4‐(acetylamino) phenyl] acrylic acid, D‐raffinose, LysoPC (15 : 1), methyl 10‐undecenoate, PE (18 : 1/20 : 4), and D‐glucose6‐phosphate. These metabolites are associated with arginine and proline metabolism, arginine biosynthesis, pyrimidine metabolism, and glycerophospholipid metabolism. Correlation analysis indicated that arginine and proline metabolism and pyrimidine metabolism metabolic pathways were identified as the common metabolic pathways of 16s rRNA sequencing and untargeted metabolomics. In conclusion, our results showed that QFSS could ameliorate asthma in mice. The possible mechanism of QFSS on asthma may be associated with regulating the gut microbiota and arginine and proline metabolism and pyrimidine metabolism. Our study may be useful for researchers to study the integrative mechanisms of Chinese herbal formulas based on modulating gut microbiota and metabolism.
Simulation Study of Aviation Emergency Rescue Process Based on Application Scenario Features
Authors: Zhang Yichi
Published: February 2023

In the process of emergency relief material dispatching, most of the traditional algorithms for dispatching are for single rescue point and single material dispatching, which cannot solve the problem of multirescue emergency relief dispatching. The various supply and demand points for emergency relief materials and the multiple emergency relief material dispatching are utilized to create the multiobjective planning model, which is then used as the optimization objective to create the best material dispatching plan. Genetic algorithm (GA) is used to solve the optimal material dispatching scheme and symbolic coding; special pulse crossover operator and variational operator are used to ensure the quality of the solution. The experiment proves that the simulation method of the aviation emergency rescue process considering the application scenario characteristics is efficient in the emergency rescue process and can meet the application requirements of material dispatching in the process of civil emergency disaster relief.
Naringin Protects against Tau Hyperphosphorylation in Aβ25–35-Injured PC12 Cells through Modulation of ER, PI3K/AKT, and GSK-3β Signaling Pathways
Authors: Qiu Qi , Lei Xia , Wang Yueying , Xiong Hui , Xu Yanming , Sun Huifeng , Xu Hongdan , Zhang Ning
Published: February 2023

Alzheimer’s disease (AD) is the most common form of dementia and a significant social and economic burden. Estrogens can exert neuroprotective effects and may contribute to the prevention, attenuation, or even delay in the onset of AD; however, long-term estrogen therapy is associated with harmful side effects. Thus, estrogen alternatives are of interest for countering AD. Naringin, a phytoestrogen, is a key active ingredient in the traditional Chinese medicine Drynaria. Naringin is known to protect against nerve injury induced by amyloid beta-protein (Aβ) 25–35, but the underlying mechanisms of this protection are unclear. To investigate the mechanisms of naringin neuroprotection, we observed the protective effect on Aβ25–35-injured C57BL/6J mice’s learning and memory ability and hippocampal neurons. Then, an Aβ25–35 injury model was established with adrenal phaeochromocytoma (PC12) cells. We examined the effect of naringin treatment on Aβ25–35-injured PC12 cells and its relationship with estrogen receptor (ER), phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), and glycogen synthase kinase (GSK)-3β signaling pathways. Estradiol (E2) was used as a positive control for neuroprotection. Naringin treatment resulted in improved learning and memory ability, the morphology of hippocampal neurons, increased cell viability, and reduced apoptosis. We next examined the expression of ERβ, p-AKT (Ser473, Thr308), AKT, p-GSK-3β (Ser9), GSK-3β, p-Tau (Thr231, Ser396), and Tau in PC12 cells treated with Aβ25–35 and either naringin or E2, with and without inhibitors of the ER, PI3K/AKT, and GSK-3β pathways. Our results demonstrated that naringin inhibits Aβ25–35-induced Tau hyperphosphorylation by modulating the ER, PI3K/AKT, and GSK-3β signaling pathways. Furthermore, the neuroprotective effects of naringin were comparable to those of E2 in all treatment groups. Thus, our results have furthered our understanding of naringin’s neuroprotective mechanisms and indicate that naringin may comprise a viable alternative to estrogen therapy.
Combination Therapy with Indigo and Indirubin for Ulcerative Colitis via Reinforcing Intestinal Barrier Function
Authors: Xie Jin , Tian Shimin , Liu Jun , Huang Shengjie , Yang Ming , Yang Xiangbo , Xu Runchun , Lin Junzhi , Han Li , Zhang Dingkun
Published: February 2023

Indigo and indirubin, the active molecules of traditional Chinese medicine indigo naturalis, exert therapeutic activity for ulcerative colitis (UC). Indigo and indirubin are isomers and have distinctive profiles in anti-inflammation, immune regulation, intestinal microbiota regulation, oxidative stress regulation, and intestinal mucosal repair for UC treatment. Thus, exploring its combined administration’s integrated advantages for UC is critical. This study is aimed at clarifying the effect and mechanisms of the combined administration of indigo and indirubin on colitis mouse models. The results showed that all the treatment groups could improve the disease symptoms, and the combined administration showed the best effect. Additionally, compared with indigo and indirubin alone, the combination group could significantly reinforce intestinal barrier function by increasing the expression of E-cadherin, occludin, ZO-1, and MUC2 and improving intestinal permeability. The treatment groups significantly improved the expression of cytokines, including TNF-α, IFN-γ, IL-12, IL-23, and IL-17A, and indirubin presented the most potent anti-inflammatory effect. Furthermore, all the treatment groups reduced the infiltration of the immune cells in intestinal lamina propria and the production of ROS/RNS. Notably, indigo exhibited a more substantial capacity to regulate natural killer (NK) cells, ILC3, neutrophils, and dendritic cells, followed by the combination group and indirubin alone. Finally, all the treatment groups modulated intestinal microbiota composition, increased the proportion of beneficial microbiota, and decreased the proportion of microbiota. Our results indicated that indigo and indirubin synergistically reinforced the intestinal barrier function, which may be associated with integrating the indirubin anti-inflammatory and intestinal microbiota regulating strength and indigo immune and ROS/RNS regulation advantage.
Optimization of Fleet’s Level Repair Plan for Diverse Missions
Authors: Jiang Tiejun , Yu Chun
Published: February 2023

Various missions significantly impact the fleet’s level repair plan. The mission requirement model is established based on the “regular and dual control” repair mode. Considering the fleet’s overall operation, capability decay characteristics, and planner’s expectations and preferences, the fleet’s capability evaluation model is constructed. Furthermore, aiming at the maximum capability value and the minimum number of the mission ships and comprehensively considering constraints such as sailing rate, mission period, repair period, repair cost, capability restoration, and mission capability, the optimization model of the fleet’s level repair plan for diverse missions is established. The particle swarm optimization algorithm based on the hierarchical sequence method is used to solve the model, and the fleet’s level repair plan and mission configuration plan are obtained, which solves the coordination problem of the two types of plans. The results show that, compared with the traditional planning method, this method can fully consider the actual requirements of diverse missions and has better coordination of the relationship between the ship’s use and repair. This method can provide strong technical support for the scientific preparation of level repair plans and the effective completion of combat readiness training missions.
Performance Analysis of IEEE 802.11p Protocol in IoV under Error-Prone Channel Conditions
Authors: Li Suoping , Li Hongli , Gaber Jaafar , Yang Sa , Yang Qian
Published: February 2023

The complexity of the channel condition in the Internet of vehicles (IoV) may increase the bit error rate (BER) of the intelligent vehicle terminals, resulting in data transmission failures or errors. Therefore, it is necessary to improve the performance of communication protocols under error-prone channel conditions. This article investigates the influence of the access categories’ (ACs) performance with channel errors by using four

A
C
s

to cause service differentiation based on the enhanced distributed channel access (EDCA) mechanism of the IEEE 802.11p. To address the error-prone characteristics of the channel and unsaturated traffic conditions, a three-dimensional Markov model is developed first, followed by an analysis of the characteristics and mutual transition probabilities of the seven classes of states in the model, and then, the steady-state equations of the system are developed to derive the steady-state distribution to study system performance. The model considers the backoff phase, the freezing of the backoff counter, the retransmission limit, the probability of collisions occurring, the size of the maximum and minimum contention window, and the number of interframe intervals. These parameters are chosen to meet the requirements for the protocol to operate, while also preventing overestimation of throughput and avoiding having packets being served all the time. We derive expressions for the throughput and delay of

A
C
s

under the conditions of error channels and unsaturated traffic. The impact of channel errors on the throughput and delay of

A
C
s

is evaluated by numerical simulation. Numerical results show that too many stations in the system will increase the average access delay and decrease throughput. The increase in BER will seriously decrease the performance of high-priority

A

C

s

. The throughput of the

A
C
s

is also modeled to vary with frame length and BER, and the variation curves of the optimal frame lengths for

A
C
3

and

A
C
2

were obtained.
Regulation of Chondrocyte Differentiation by miR-455-3p Secreted by Bone Marrow Stem Cells through Phosphatase and Tensin Homolog Deleted on Chromosome Ten/Phosphoinositide 3-Kinase-Protein Kinase B
Authors: He Axiang , Liu Yaru , Sang Shang , Zhang Renbo , Jiang Zheng , Mao Yanjie , Liu Wanjun
Published: February 2023

The effects of the regulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN) by microribonucleic acid- (miR-) 455-3p on bone marrow stem cells’ (BMSCs’) chondrogenic development were examined based on the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signal pathway. The alterations in miR-455-3p and PTEN were identified using osteoarthritis (OA) and healthy chondrocytes. Rats raised on the SD diet had their BMSCs isolated for chondrocyte-induced differentiation (blank group), transfected miR-455-3p mimic (mimic group), and inhibitor (inhibitor group). Besides, cell proliferation, alizarin red mineralization staining, and the activity of alkaline phosphatase (ALP) were detected. Real-time fluorescent quantitation polymerase chain reaction (PCR) and Western blot were utilized to detect Runx2, OPN, OSX, COL2A1 mRNA, and the difference between PI3K and AKT. Dual-luciferase reporter (DLR) genes were selected to analyze the target relationship of miR-455-3p to PTEN. It was demonstrated that miR-455-3p in OA was downregulated, while PTEN was upregulated (

P
<
0.05

) in comparison to healthy chondrocytes (

P
<
0.05

). Versus those in the blank group, alizarin red mineralization staining and the activity of ALP increased; RUNX, OPN, OSX, COL2A1 mRNA, p-PI3K, and p-AKT were elevated in the mimic group (

P
<
0.05

). Versus those in the blank and mimic groups, alizarin red mineralization staining and the activity of ALP reduced; RUNX, OPN, OSX, COL2A1 mRNA, p-PI3K, and p-AKT were downregulated in the inhibitor group (

P
<
0.05

). miR-455-3p could target PTEN to inhibit its expression, thus activating the PI3K/AKT signal pathway and promoting BMSCs chondrocyte-induced differentiation. The research results provided reference for the occurrence of OA and the study on therapeutic target.
Identification of Clinical Prognostic Regulators and Analysis of Ferroptosis-Related Signatures in the Tumor Immune Microenvironment in Lung Squamous Cell Carcinoma
Authors: Wang Wentao , Cui Guanghui , Zhao Song
Published: February 2023

Objective. Lung squamous cell carcinoma (LUSC) is a common respiratory malignancy and presents an increasing prevalence. Ferroptosis is a newly identified controlled cell death that has captured clinical attention worldwide. However, the ferroptosis-related lncRNA expression in LUSC and its relevance to prognosis remain elusive. Methods. The research measured predictive ferroptosis-related lncRNAs in LUSC samples from the TCGA datasets. Data on the stemness indices (mRNAsi) and corresponding clinical characteristics were obtained from TCGA. A prognosis model was established using the LASSO regression. Changes within the neoplasm microenvironment (TME) and medicine association were examined to grasp higher immune cell infiltration in numerous risk teams. In line with coexpression studies, the expression of lncRNAs is closely associated with that of ferroptosis. They were overexpressed in unsound people in the absence of alternative clinical symptoms. Results. The low-risk and speculative teams were considered to have substantial differences in CCR and inflammation-promoting genes. C10orf55, AC016924.1, AL161431.1, LUCAT1, AC104248.1, and MIR3945HG were highly expressed in the high-risk group, suggesting their involvement in the oncology process of LUSC. Moreover, AP006545.2 and AL122125.1 were considerably higher in the low-risk group, implying the potential of these genes as LUSC tumor suppressor genes. The biomarkers listed above may serve as therapeutic targets for LUSC. lncRNAs were also linked to patient outcomes in the LUSC trial. Conclusion. lncRNAs of ferroptosis were overexpressed in the high-risk cohort without other clinical signs, implying their potential to predict BLCA prognosis. GSEA highlighted immunological and tumor-related pathways in the high-risk group. LUSC occurrence and progression are linked to lncRNAs of ferroptosis. Corresponding prognostic models help forecast the prognosis of LUSC patients. lncRNAs of ferroptosis and associated immune cell infiltration in the tumor microenvironment (TME) may serve as potential therapeutic targets in LUSC, which requires further trials. In addition, the lncRNAs of ferroptosis signature offer a viable alternative to predict LUSC, and these ferroptosis-lncRNAs show a prospective research area for LUSC-targeted treatment in the future.
Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death
Authors: Avelar Rita A. , Armstrong Amy J. , Carvette Gracie , Gupta Riya , Puleo Noah , Colina Jose A. , Joseph Peronne , Sobeck Alexander M. , O'Connor Caitlin M. , Raines Brynne , Gandhi Agharnan , Dziubinski Michele L. , Ma Daniel S. , Resnick Kimberly , Singh Sareena , Zanotti Kristine , Nagel Christa , Waggoner Steven , Thomas Daffyd G. , Skala Stephanie L. , Zhang Junran , Narla Goutham , DiFeo Analisa
Published: February 2023

High-grade serous carcinoma (HGSC) is the most common and lethal ovarian cancer subtype. PARP inhibitors (PARPi) have become the mainstay of HGSC-targeted therapy, given that these tumors are driven by a high degree of genomic instability (GI) and homologous recombination (HR) defects. Nonetheless, approximately 30% of patients initially respond to treatment, ultimately relapsing with resistant disease. Thus, despite recent advances in drug development and an increased understanding of genetic alterations driving HGSC progression, mortality has not declined, highlighting the need for novel therapies. Using a small-molecule activator of protein phosphatase 2A (PP2A; SMAP-061), we investigated the mechanism by which PP2A stabilization induces apoptosis in patient-derived HGSC cells and xenograft (PDX) models alone or in combination with PARPi. We uncovered that PP2A genes essential for cellular transformation (B56α, B56γ, and PR72) and basal phosphatase activity (PP2A-A and -C) are heterozygously lost in the majority of HGSC. Moreover, loss of these PP2A genes correlates with worse overall patient survival. We show that SMAP-061–induced stabilization of PP2A inhibits the HR output by targeting RAD51, leading to chronic accumulation of DNA damage and ultimately apoptosis. Furthermore, combination of SMAP-061 and PARPi leads to enhanced apoptosis in both HR-proficient and HR-deficient HGSC cells and PDX models. Our studies identify PP2A as a novel regulator of HR and indicate PP2A modulators as a therapeutic therapy for HGSC. In summary, our findings further emphasize the potential of PP2A modulators to overcome PARPi insensitivity, given that targeting RAD51 presents benefits in overcoming PARPi resistance driven by BRCA1/2 mutation reversions.
AST-120 to Target Protein-Bound Uremic Toxins Improves Cardiac Output and Kidney Oxygenation in Experimental Chronic Kidney Disease
Authors: Sivertsson Ebba , Ceder Sara , Nangaku Masaomi , Hansell Peter , Nordquist Lina , Palm Fredrik
Published: February 2023

Introduction: Chronic kidney disease (CKD) is a global health problem with increasing incidence which is closely associated with cardiac dysfunction. In CKD, uremic toxins accumulate as kidney function declines. Additionally, high salt intake is a growing health issue worldwide which can exacerbate kidney disease. In this study, we investigated the effect of reducing plasma levels of protein-bound uremic toxins in a rat model of CKD, challenged with high salt intake and compared the effects to those of conventional treatment using an angiotensin-converting enzyme inhibitor (ACEI). Methods: In rats, the right kidney and 2/3 of the left kidney were surgically removed (5/6 nephrectomy). Animals were fed a normal-salt diet and randomized to either no treatment (control) or chronic treatment with either the oral absorbent AST-120 to reduce plasma levels of protein-bound uremic toxins or the ACEI enalapril to inhibit angiotensin II signaling for 5 weeks. Following treatment, kidney function was measured before and after a week of high salt intake. Cardiac output and markers of oxidative stress were measured at the end of the study period. Results: Treatment with AST-120 resulted in decreased levels of the uremic toxin indoxyl sulfate, improved cardiac output (mL/min: AST-120 44.9 ± 5.4 compared to control 26.6 ± 2.0; p < 0.05), and decreased urinary oxidative stress. ACEI reduced oxidative stress in kidney tissue and improved the glomerular filtration rate in response to high salt intake (mL/min: ACEI 1.5 ± 0.1; compared to control 1.1 ± 0.1; p < 0.05). Both interventions improved intrarenal oxygen availability (mm Hg: AST-120 42.8 ± 0.8; ACEI 43.2 ± 1.9; compared to control 33.4 ± 1.3; p < 0.05). Conclusion: AST-120 administered to reduce plasma levels of uremic toxins, such as indoxyl sulfate, has potential beneficial effects on both cardiac and kidney function. Targeting uremic toxins and angiotensin II signaling simultaneously could be an efficient strategy to target both cardiac and kidney dysfunction in CKD, to further slow progression of disease in patients with CKD.
Artificial Intelligence in Bone Marrow Histological Diagnostics: Potential Applications and Challenges
Authors: van Eekelen Leander , Litjens Geert , Hebeda Konnie M.
Published: February 2023

The expanding digitalization of routine diagnostic histological slides holds a potential to apply artificial intelligence (AI) to pathology, including bone marrow (BM) histology. In this perspective, we describe potential tasks in diagnostics that can be supported, investigations that can be guided, and questions that can be answered by the future application of AI on whole-slide images of BM biopsies. These range from characterization of cell lineages and quantification of cells and stromal structures to disease prediction. First glimpses show an exciting potential to detect subtle phenotypic changes with AI that are due to specific genotypes. The discussion is illustrated by examples of current AI research using BM biopsy slides. In addition, we briefly discuss current challenges for implementation of AI-supported diagnostics.
Um panorama bibliométrico do storytelling no turismo: por uma atualização conceitual ao uso das narrativas
Authors: Casado Cristiano Silva , Ruiz Thays Cristina Domareski
Published: February 2023

Inovações tecnológicas permitiram maior fluidez e alcance das mensagens, com participação do público-alvo na geração de conteúdo, e mudaram as narrativas. O transmedia storytelling se insere neste contexto de transformação. O desenvolvimento das histórias se dá pela participação de diversos sujeitos que atuam voluntariamente na construção colaborativa. Ao combinar a narrativa com o turismo, antecipam-se formas de comunicação, trazendo novas oportunidades com o aprimoramento das estratégias de comunicação e marketing. Por ser um estudo exploratório, este artigo realizou revisão bibliométrica da literatura para traçar um panorama a respeito do uso do storytelling nas pesquisas acadêmicas em turismo. Foram empregadas as palavras-chave “storytelling” e “tourism” em duas bases de dados (Web of Science e SciELO). Compilou-se uma amostra de 129 artigos. Os resultados apontaram que o estudo da temática é recente; a amostra final apresentou estudos publicados nos últimos 19 anos e os principais temas abordados envolvem linguagem, tecnologia da informação e da comunicação, experiência/emoção, identidade/memória e estratégia/marketing. Verificou-se que o turismo aborda a narrativa predominantemente como um conceito da narratividade na comunicação humana ou características de disseminação em plataformas digitais. Apenas cerca de 3% (quatro artigos) abordam o transmedia storytelling. Portanto, a abordagem do storytelling está empregada de forma parcial, fora do contexto da convergência midiática, abrindo caminho para a interdisciplinaridade do turismo e da comunicação. Os resultados contribuem para o aprofundamento desta perspectiva teórica, com um tema atual e que está em evidência, pois promoveu-se um delineamento do campo científico.
La intervención multimedia del espacio público: una dinámica de flujos audiovisuales
Authors: Urrutia Hernando
Published: February 2023

Este artículo propone discutir la importancia social de la intervención multimedia en el espacio urbano de la ciudad como un proceso de sensibilización, desde la intervención y conexión con los nuevos lenguajes tecnológicos de las artes audiovisuales digitales, a través de la relación directa de la mediación de flujos de la video proyección en el espacio público, con el dinamismo digital de las nuevas narrativas de artefactos audiovisuales computacionales, como una forma de apropiación del espacio público, abriendo nuevas posibilidades en el tejido cultural de la ciudad en conexión con el ciudadano.
Métodos para criação de narrativas imersivas: uma revisão de revisões da literatura
Authors: Bonfim Cristiane Jorge de Lima , Morgado Leonel , Pedrosa Daniela Cristina Carneiro
Published: February 2023

O conceito de narrativa imersiva enfoca narrativas enquanto forma de promover o estado psicológico de imersão do público-alvo. Este artigo apresenta o resultado de uma revisão de revisões de literatura que objetivou identificar os principais métodos para concepção e criação de narrativas imersivas, considerando aspectos estruturais e elementos específicos, como personagens e cenários. Os resultados revelaram cinco clusters com características diferenciadas, considerando as dimensões da imersão narrativa temporal, espacial e emocional.
Believability in virtual reality: a proposal to study brand communication in metaverses
Authors: Borba Eduardo Zilles
Published: February 2023

The article presents a theoretical and empirical exercise to the possibilities of brand communication in virtual reality (VR), proposing an analysis/creation tool for emerging metaverse platforms, applied to the field of brand communication (immersive and 360-degree images, multisensoriality, first person perspective). Methodologically, this study uses an empirical approach, qualitatively evaluating an advertising piece in VR and highlighting the dimensions of believability that, in some way, affect brand communication. Results show three relevant dimensions: realism, interactivity, and engagement with the plot.
Imersão histórica: realidade virtual sobre o terremoto de 1755 no quake e no lisboa story centre
Authors: Tarapanoff Fabíola Paes de Almeida
Published: February 2023

"Não é uma questão de se, é uma questão de quando.” A frase de Ricardo Clemente, fundador do Quake, mostra a importância de estar preparado para tragédias. Inaugurado em 2022, a atração permite uma experiência imersiva até o Terremoto de 1755. Assim como o Lisboa Story Centre, que conta a história da cidade de forma interativa. O objetivo é entender como espaços culturais utilizam a imersão, a interatividade e o storytelling. A metodologia inclui levantamento bibliográfico e visitas guiadas.
Total refusal: por uma desobediência digital criativa
Authors: Murari Lucas
Published: February 2023

Este artigo tem como intuito estudar a obra do Total Refusal, coletivo fundado na Áustria em 2018. O grupo tem como base ações de guerrilha midiáticas que exploram estratégias de intervenção artística em jogos de computador contemporâneos e outros dispositivos de realidade virtual, a partir da apropriação e ressignificação de materiais audiovisuais. O objetivo é investigar os aparatos estético-políticos presentes no filme How to Disappear – Deserting Battlefield (2020). A técnica conhecida como machinima é fundamental para o entender os procedimentos adotados pelo coletivo e será apresentada nesta discussão.
Portrait Map Art Generation By Asymmetric Image-to-Image Translation
Authors: Zhang Yuxin , Tang Fan , Dong Weiming , Le Thi-Ngoc-Hanh , Xu Changsheng , Lee Tong-Yee
Published: February 2023

The authors propose a deep neural network–based algorithm to automatically generate portrait map art (PMA), a modern art form created by British portrait artist Ed Fairburn. The authors formulate the generation of PMA as an adaptive dual-to-single image translation problem. The authors’ proposed model analyzes the appearance of one portrait and one map image using two encoder networks and utilizes their hidden encodings as representations of the portrait and map image to generate new PMA using a decoder network. An adaptive style harmonization module is proposed to fuse the two hidden encodings. Optimized by cycle-consistency constraint, the model can produce new PMA images without baselines.
Leucoagaricus purpurascens, a new species from eastern China based on morphological characteristics and molecular evidence
Authors: GUO TING , MA YUN-RUI , YANG RUI-HENG , GE ZAI-WEI , BAO DA-PENG
Published: February 2023

A new species, Leucoagaricus purpurascens, collected from a subtropical region in China, is described based on morphological and molecular data. Leucoagaricus purpurascens is characterized by its small basidiomata with purple discolouration when dried, the pileus with distinct umbo, the amygdaliform, ellipsoidal to oblong basidiospores, and the absence of cheilocystidia. A detailed morphological description, line drawings, colour photographs, and a phylogenetic tree showing the phylogenetic placement of the new species are provided.
Stigmatodon enigmaticus (Bromeliaceae, Tillandsioideae), a new lithophytic species from the Campos Rupestres within the Brazilian Atlantic Forest
Authors: COUTO DAYVID R. , GONELLA PAULO M. , COSTA ANDREA F.
Published: February 2023

Stigmatodon enigmaticus is described and illustrated as a new lithophytic taxon from the quartzitic Campos Rupestres within the biodiversity hotspot of the Atlantic Forest, in Minas Gerais state, Southeastern Brazil. This puzzling new species presents floral features that are unique in the genus as they are associated with ornithophily, as in most Vriesea, contrasting with the chiropterous features of all previously known Stigmatodon species. It is assigned to the “S. limae group”, being most similar to S. vexatus, with which it is compared. Stigmatodon enigmaticus is a microendemic species and is here assessed as Critically Endangered due to its restricted habitat, reduced population size, and threats from invasive species. This finding adds to several others that reinforce the relevance of the currently unprotected Serra do Padre Ângelo as a priority for conservation.
Review of Admirandus Belogurov & Belogurova, 1979 (Nematoda, Oncholaimidae) with the description of a new species and the first record of the genus from Brazil
Authors: CAVALCANTI MARIANA DA FONSECA , GUILHERME BETÂNIA C. , ROSA-FILHO JOSÉ SOUTO
Published: February 2023

The present study provides a description of a new Admirandus species from northeastern Brazil, together with an updated species identification key. Admirandus capibaribei sp. n. can be distinguished from all the other Admirandus species by its physical dimensions (body length, a, stoma and spicule ratios), sexual dimorphism of the tail, the absence of pre-cloacal supplements, and the presence of a row of denticles at the base of the right ventrosublateral tooth. While Admirandus has been reported from temperate, subtropical and tropical environments around the world, this is the first record of the genus from Brazil. Further research on Admirandus and other Adoncholaiminae species, which include the integration of morphological and molecular approaches, will be important to provide a better understanding of the taxonomy of this group, as well as on its demanian system.
Design of Sixteen-Input Priority Encoder with DNA Nano Switches
Authors: Huang Chun , Zhang Xinya , Li Panlong , Sun Junwei , Zhang Xuncai , Wang Yanfeng
Published: February 2023

With the application of DNA computing in more and more fields, the tasks are becoming more and more complex, and the scale of DNA circuits is gradually increasing. However, the current investigation of largescale circuits of DNA molecules is still a challenge. So it is crucial to optimize
the performance of large-scale DNA circuits. In this paper, a large-scale digital logic circuit 16-Input-5-Output Priority Encoder is realized by using the DNA nano switches for the first time. The simulation of the 16-Input-5-Output Priority Encoder circuit shows that this method solves the
problems of NOT gate instability and optimizes the DNA circuit in terms of reaction time, circuit complexity, and experimental difficulty. This paper proves the feasibility and superiority of using DNA nano switches to realize large-scale circuits, provides a new idea for realizing large-scale
DNA circuits, and brings new development for the application of DNA circuits in biosensor, DNA complex computing and other fields.
Design and Simulation of Low Power Differential Transimpedance Amplifier Using Degenerations Capacitors
Authors: Singh Priya , Niranjan Vandana , Kumar Ashwni
Published: February 2023

In today’s internet-connected culture, high-speed data transmission techniques are in high demand. Optical communication is most used techniques for data transmission with speed. High-speed amplifiers are needed, nevertheless, to obtain high gains and transform current signals
into voltage gains. This is accomplished via transimpedance amplifiers, a crucial component of optical receivers. In this work, a high-speed transimpedance amplifier with negative degeneration capacitors and complete differential operation is built. The proposed design has a transimpedance
gain of approximately 52.4 dB at 19.8 GHz and an average input-referred noise current of roughly 23.3 pA/√Hz. The suggested circuit also has an high gain, and low input-referred noise, excellent bandwidth all of which contribute to its low power consumption of roughly 215 uW. This makes
it appropriate for Internet of Things (IoT) devices, smart devices, mobile phones, laptops, and other computer peripherals.
Moist Thermodynamics of Convectively Coupled Waves over the Western Hemisphere
Authors: Mayta Víctor C. , Adames Ángel F.
Published: February 2023

Convectively coupled waves (CCWs) over the Western Hemisphere are classified based on their governing thermodynamics. It is found that only the tropical depressions (TDs; TD waves) satisfy the criteria necessary to be considered a moisture mode, as in the Rossby-like wave found in an earlier study. In this wave, water vapor fluctuations play a much greater role in the thermodynamics than temperature fluctuations. Only in the eastward-propagating inertio-gravity (EIG) wave does temperature govern the thermodynamics. Temperature and moisture play comparable roles in all the other waves, including the Madden–Julian oscillation over the Western Hemisphere (MJO-W). The moist static energy (MSE) budget of CCWs is investigated by analyzing ERA5 data and data from the 2014/15 observations and modeling of the Green Ocean Amazon (GoAmazon 2014/15) field campaign. Results reveal that vertical advection of MSE acts as a primary driver of the propagation of column MSE in westward inertio-gravity (WIG) wave, Kelvin wave, and MJO-W, while horizontal advection plays a central role in the mixed Rossby gravity (MRG) and TD wave. Results also suggest that cloud radiative heating and the horizontal MSE advection govern the maintenance of most of the CCWs. Major disagreements are found between ERA5 and GoAmazon. In GoAmazon, convection is more tightly coupled to variations in column MSE, and vertical MSE advection plays a more prominent role in the MSE tendency. These results along with substantial budget residuals found in ERA5 data suggest that CCWs over the tropical Western Hemisphere are not represented adequately in the reanalysis.

Significance Statement

In comparison to other regions of the globe, the weather systems that affect precipitation in the tropical Western Hemisphere have received little attention. In this study, we investigate the structure, propagation, and thermodynamics of convectively coupled waves that impact precipitation in this region. We found that slowly evolving tropical systems are “moisture modes,” i.e., moving regions of high humidity and precipitation that are maintained by interactions between clouds and radiation. The faster waves are systems that exhibit relatively larger fluctuations in temperature. Vertical motions are more important for the movement of rainfall in these waves. Last, we found that reanalysis and observations disagree over the importance of different processes in the waves that occurred over the Amazon region, hinting at potential deficiencies on how the reanalysis represents clouds in this region.
Treatment of Primary Hyperparathyroidism in the Setting of Tatton-Brown-Rahman Syndrome
Authors: Kalil Grant H. , Christopher Wade O. , Brister Kelly A. , Orr Wayne S.
Published: February 2023

Tatton-Brown-Rahman syndrome (TBRS) is a rare overgrowth syndrome first described in 2014.1 This report describes a 17-year-old male with TBRS who presented with primary hyperparathyroidism (PH) and was found to have sestamibi positive imaging. The patient underwent a bilateral neck exploration where an ectopic parathyroid gland was localized and removed. The patient had no surgical complications, and his follow up visit showed normalization of parathyroid hormone and calcium levels. This report represents the importance of obtaining multiple imaging modalities during preoperative preparation for a parathyroidectomy in patients with TBRS. It also demonstrates the need for further publications of anatomic anomalies associated with PH in patients with TBRS in the future.