bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of hypoxia and reoxygenation on mitochondrial functions and transcriptional profiles of isolated brain and muscle porcine cells
Authors: Adzigbli Linda , Sokolov Eugene P. , Wimmers Klaus , Sokolova Inna M. , Ponsuksili Siriluck
Published: November 2022

Oxygen fluctuations might occur in mammalian tissues under physiological (e.g. at high altitudes) or pathological (e.g. ischemia–reperfusion) conditions. Mitochondria are the key target and potential amplifiers of hypoxia-reoxygenation (H-R) stress. Understanding the mitochondrial responses to H-R stress is important for identifying adaptive mechanisms and potential therapeutic solutions for pathologies associated with oxygen fluctuations. We explored metabolic response to H-R stress in two tissue types (muscle and brain) with different degrees of hypoxia tolerance in a domestic pigSus scrofafocusing on the cellular responses independent of the systemic regulatory mechanisms. Isolated cells from the skeletal muscle (masseter) and brain (thalamus) were exposed to acute short-term (15 min) hypoxia followed by reoxygenation. The mitochondrial oxygen consumption, reactive oxygen species (ROS) production rates and transcriptional profiles of hypoxia-responsive mRNA and miRNA were determined. Mitochondria of the porcine brain cells showed a decrease in the resting respiration and ATP synthesis capacity whereas the mitochondria from the muscle cells showed robust respiration and less susceptibility to H-R stress. ROS production was not affected by the short-term H-R stress in the brain or muscle cells. Transcriptionally, prolyl hydroxylase domain protein EGLN3 was upregulated during hypoxia and suppressed during reoxygenation in porcine muscle cells. The decline in EGLN3 mRNA during reoxygenation was accompanied by an upregulation of hypoxia-inducible factor subunit α (HIF1A)transcripts in the muscle cells. However, in the brain cells, HIF1A mRNA levels were suppressed during reoxygenation. Other functionally important transcripts and miRNAs involved in antioxidant response, apoptosis, inflammation, and substrate oxidation were also differentially expressed between the muscle and brain cells. Suppression of miRNA levels during acute intermittent hypoxia was stronger in the brain cells affecting ~ 55% of all studied miRNA transcripts than in the muscle cells (~ 25% of miRNA) signifying transcriptional derepression of the respective mRNA targets. Our study provides insights into the potential molecular and physiological mechanisms contributing to different hypoxia sensitivity of the studied tissues and can serve as a starting point to better understand the biological processes associated with hypoxia stress, e.g. during ischemia and reperfusion.
Identifying behavioral structure from deep variational embeddings of animal motion
Authors: Luxem Kevin , Mocellin Petra , Fuhrmann Falko , Kürsch Johannes , Miller Stephanie R. , Palop Jorge J. , Remy Stefan , Bauer Pavol
Published: November 2022

Quantification and detection of the hierarchical organization of behavior is a major challenge in neuroscience. Recent advances in markerless pose estimation enable the visualization of high-dimensional spatiotemporal behavioral dynamics of animal motion. However, robust and reliable technical approaches are needed to uncover underlying structure in these data and to segment behavior into discrete hierarchically organized motifs. Here, we present an unsupervised probabilistic deep learning framework that identifies behavioral structure from deep variational embeddings of animal motion (VAME). By using a mouse model of beta amyloidosis as a use case, we show that VAME not only identifies discrete behavioral motifs, but also captures a hierarchical representation of the motif’s usage. The approach allows for the grouping of motifs into communities and the detection of differences in community-specific motif usage of individual mouse cohorts that were undetectable by human visual observation. Thus, we present a robust approach for the segmentation of animal motion that is applicable to a wide range of experimental setups, models and conditions without requiring supervised or a-priori human interference.
Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel
Authors: Slobodyanyuk Mykhaylo , Banda-Vázquez Jesús A. , Thompson Mackenzie J. , Dean Rebecca A. , Baenziger John E. , Chica Roberto A. , daCosta Corrie J. B.
Published: November 2022

ELIC is a prokaryotic homopentameric ligand-gated ion channel that is homologous to vertebrate nicotinic acetylcholine receptors. Acetylcholine binds to ELIC but fails to activate it, despite bringing about conformational changes indicative of activation. Instead, acetylcholine competitively inhibits agonist-activated ELIC currents. What makes acetylcholine an agonist in an acetylcholine receptor context, and an antagonist in an ELIC context, is not known. Here we use available structures and statistical coupling analysis to identify residues in the ELIC agonist-binding site that contribute to agonism. Substitution of these ELIC residues for their acetylcholine receptor counterparts does not convert acetylcholine into an ELIC agonist, but in some cases reduces the sensitivity of ELIC to acetylcholine antagonism. Acetylcholine antagonism can be abolished by combining two substitutions that together appear to knock out acetylcholine binding. Thus, making the ELIC agonist-binding site more acetylcholine receptor-like, paradoxically reduces the apparent affinity for acetylcholine, demonstrating that residues important for agonist binding in one context can be deleterious in another. These findings reinforce the notion that although agonism originates from local interactions within the agonist-binding site, it is a global property with cryptic contributions from distant residues. Finally, our results highlight an underappreciated mechanism of antagonism, where agonists with appreciable affinity, but negligible efficacy, present as competitive antagonists.
Role of Van Hove singularities and effective mass anisotropy in polarization-resolved high harmonic spectroscopy of silicon
Authors: Suthar Pawan , Trojánek František , Malý Petr , Derrien Thibault J.-Y. , Kozák Martin
Published: November 2022

Nonlinear optical response of materials exposed to strong nonresonant light fields leads to production of high energy photons whose spectra contain fingerprints of the coherent electron dynamics in the material. In this paper we investigate how the high harmonic spectra generated in crystalline silicon are linked to specific properties of its band structure. By comparing the polarization anisotropy of high harmonic spectra for two distinct frequencies of the driving pulses we show that the anisotropy has two sources. When driven by mid-infrared light, the signal at specific photon energies is enhanced by the presence of Van Hove singularities in the joint density of states of silicon. With near-infrared driving pulses, in contrast, the high harmonic yield is mainly influenced by the anisotropy of the reduced mass of electron-hole pair, which is related to the nonresonant excitation probability. The experimental results are compared with numerical calculations using time-dependent density functional theory.
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity
Authors: Bondareva Olga , Rodríguez-Aguilera Jesús Rafael , Oliveira Fabiana , Liao Longsheng , Rose Alina , Gupta Anubhuti , Singh Kunal , Geier Florian , Schuster Jenny , Boeckel Jes-Niels , Buescher Joerg M. , Kohli Shrey , Klöting Nora , Isermann Berend , Blüher Matthias , Sheikh Bilal N.
Published: November 2022

Obesity promotes diverse pathologies, including atherosclerosis and dementia, which frequently involve vascular defects and endothelial cell (EC) dysfunction. Each organ has distinct EC subtypes, but whether ECs are differentially affected by obesity is unknown. Here we use single-cell RNA sequencing to analyze transcriptomes of ~375,000 ECs from seven organs in male mice at progressive stages of obesity to identify organ-specific vulnerabilities. We find that obesity deregulates gene expression networks, including lipid handling, metabolic pathways and AP1 transcription factor and inflammatory signaling, in an organ- and EC-subtype-specific manner. The transcriptomic aberrations worsen with sustained obesity and are only partially mitigated by dietary intervention and weight loss. For example, dietary intervention substantially attenuates dysregulation of liver, but not kidney, EC transcriptomes. Through integration with human genome-wide association study data, we further identify a subset of vascular disease risk genes that are induced by obesity. Our work catalogs the impact of obesity on the endothelium, constitutes a useful resource and reveals leads for investigation as potential therapeutic targets.
Thermal degradation of lead halide perovskite surfaces
Authors: Kammlander Birgit , Svanström Sebastian , Kühn Danilo , Johansson Fredrik O. L. , Sinha Swarnshikha , Rensmo Håkan , Fernández Alberto García , Cappel Ute B.
Published: November 2022

The thermal degradation temperature of perovskite single crystal surfaces (MAPbI3, MAPbBr3, FAPbBr3) depends more on the halide than on the organic cation. However, different solid degradation products form depending on the cation.
One-step synthesis of epitaxial 3D/2D metal halide perovskite heterostructures
Authors: Zhu Zhaohua , Zeng Shaoyu , Chen Qian , Yang Lei , Wei Cong , Chen Bo , Yu Haidong , Li Hai , Zhang Jian , Huang Xiao
Published: November 2022

A one-step solution method was proposed to synthesize 3D/2D perovskite heterostructures, which exhibited a well-defined epitaxial structure, enabling superior photodetection performance due to effective charge transfer.
Reactivity of bi- and monometallic trifluoroacetates towards amorphous SiO2
Authors: Munasinghe Hashini N. , Imer Marcos R. , Szlag Regina G. , Suescun Leopoldo , Rabuffetti Federico A.
Published: November 2022

The reactivity of alkali–manganese(ii) and alkali trifluoroacetates towards amorphous SiO2 was studied in the solid-state with an eye towards the synthesis of alkali fluorosilicates.
Retraction: Sequestration and speciation of Eu(iii) on gamma alumina: role of temperature and contact order
Authors: Cai Yawen , Ren Xuemei , Lang Yue , Liu Zhiyong , Zong Pengfei , Wang Xiangke , Yang Shitong
Published: November 2022

Retraction of ‘Sequestration and speciation of Eu(iii) on gamma alumina: role of temperature and contact order’ by Yawen Cai et al., Environ. Sci.: Processes Impacts, 2015, 17, 1904–1914, https://doi.org/10.1039/C5EM00412H.
Enhanced sulfur resistance by constructing MnOx–Co3O4 interface on Ni foam in the removal of benzene
Authors: Han Dawei , Xiao Menglan , Wei Yuechang , Yang Xueqin , Guo Yucong , Ma Lingjuan , Yu Xiaolin , Ge Maofa
Published: November 2022

The catalytic degradation of volatile organic compounds (VOCs) in the presence of SO2 remains an urgent issue for industrial applications.
Comprehensive study about the heterogeneous conversion of NH3on nanoscale TiO2particles: insight into the mechanism and atmospheric implications
Authors: Ma Qingxin , Zhao Yaqi , Zhang Peng , Liu Chang , Lin Tao , Wang Ling , Chu Biwu , He Hong
Published: November 2022

The heterogeneous reactions of NH3on TiO2were comprehensively investigated usingin situdiffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and a flow tube reactor.
Recent advances in the application of Langlois’ reagent in olefin difunctionalization
Authors: Shen Jiabin , Li Lin , Xu Jun , Shen Chao , Zhang Pengfei
Published: November 2022

This review describes several key activation methods for Langlois' reagent in the difunctionalization of alkenes and could stimulate the interest of readers in promoting the wider development and application of Langlois' reagent.
Total synthesis of Myxoprincomide, a secondary metabolite from Myxococcus xanthus
Authors: Kohr Michael , Walt Christine , Dastbaz Jan , Müller Rolf , Kazmaier Uli
Published: November 2022

Myxoprincomide, a secondary metabolite of the myxobacterium Myxococcus xanthus DK 1622, is synthesised for the first time. The unusual α-ketoamide is formed at the end of the synthesis.
A novel efficient broadband near-infrared phosphor LiGaGe2O6:Cr3+ with EQE enhancement and spectral tuning by Sc3+–Ga3+ substitution for NIR pc-LED application
Authors: Fan Jiaqi , Zhou Weiying , Zhang Jilin , Chen Peichan , Pang Qi , Zhou Liya , Zhou Chunyan , Zhang Xinguo
Published: November 2022

High-efficint LiGaGe2O6:Cr3+ NIR phosphor is explored, and the quantum efficiency could be boosted by Sc-Ga substitution.
Asymmetric total synthesis of (+)-tubingensin A
Authors: Zhai Hongbin , Liu Dong , Wang Taimin
Published: November 2022

A nine-step asymmetric total synthesis of (+)-tubingensin A has been realized.
Copper-catalysed α-functionalization of ketones with nucleophiles: universal and efficient access to nafimidone derivatives
Authors: Shen Jiabin , Wang Zhihao , Zhang Yuru , Xu Jun , Shen Chao , Zhang Pengfei
Published: November 2022

Herein, we report our discovery of a convenient and efficient approach to construct various C–X bonds using a copper catalytic system.
Polymer-tethered glyconanoparticle colourimetric biosensors for lectin binding: structural and experimental parameters to ensure a robust output
Authors: Micallef Julian , Baker Alexander N. , Richards Sarah-Jane , Soutar Douglas E. , Georgiou Panagiotis G. , Walker Marc , Gibson Matthew I.
Published: November 2022

Polymer tethered glycosylated gold nanoparticles are optimised to provide a starting point to evaluate glycan–lectin interactions.
Kinetic Monte Carlo residence time distributions and kinetics in view of extrusion-based polymer modification and recycling
Authors: De Smit K. , Edeleva M. , Trigilio A. D. , Marien Y. W. , Van Steenberge P. H. M. , D'hooge D. R.
Published: November 2022

Coupled matrix-based kinetic Monte Carlo (CMMC) simulations are applied to obtain the residence time distribution (RTD) and molecular information (e.g.chain length distribution) per RTD slice for extrusion-based polymer modification and recycling.
Fast divalent conduction in MB12H12·12H2O (M = Zn, Mg) complex hydrides: effects of rapid crystal water exchange and application for solid-state electrolytes
Authors: Kisu Kazuaki , Dorai Arunkumar , Kim Sangryun , Hamada Riku , Kumatani Akichika , Horiguchi Yoshiko , Sato Ryuhei , Sau Kartik , Takagi Shigeyuki , Orimo Shin-ichi
Published: November 2022

Water molecules are exchanged in the crystal structure, which imparts a high divalent conductivity to hydrated complex hydrides. MB12H12·12H2O (M = Zn or Mg) exhibits exceptional conductivities higher than those of less-hydrated complex hydrides.
A flexible and stable zinc-ion hybrid capacitor with polysaccharide-reinforced cross-linked hydrogel electrolyte and binder-free carbon cathode
Authors: Gao Juntao , Guo Fengjiao , Ji Chenchen , He Xiaojun , Mi Hongyu , Qiu Jieshan
Published: November 2022

A flexible and stable zinc-ion hybrid capacitor has been fabricated with a polysaccharide-reinforced hydrogel electrolyte and binder-free carbon fabric cathode, and displays an impressive cycling performance with a capacity retention of 93.5% over 10 000 cycles as well as high energy/power density of 113.2 W h kg−1/15752.4 W kg−1.
Au-catalyzed ultrathin copper nanowires
Authors: Xu Juan , Zhu Xingzhong , Xia Sihao , Liu Yang , Kan Caixia , Shi Daning
Published: November 2022

Ultrathin Cu nanowires with diameters as thin as 7 nm are synthesized through introducing Au nanoparticles as catalytic sites and diameter controllers.
Covalent organic framework-loaded silver nanoparticles as robust mimetic oxidase for highly sensitive and selective colorimetric detection of mercury in blood
Authors: Liu Qingqing , Xu Chenchen , Chu Su , Li Shuai , Wang Fengxiang , Si Yanmei , Mao Guojiang , Wu Choufei , Wang Hua
Published: November 2022

Silver-deposited COFs were used as the oxidase mimics for the catalysis-based colorimetric detection of Hg2+ ions.
Prominent processing techniques to manipulate semiconducting polymer microstructures
Authors: Botiz Ioan
Published: November 2022

A summary of the most recent and prominent processing techniques used to manipulate semiconducting polymer microstructures.
Solution-processed and thickness-insensitive hole transport layer for high efficiency organic solar cells
Authors: Yi Xueting , Liu He , Li Youzhan , Liu Zekun , Wu Jiang , Tang Hao , Fu Yingying , Xie Zhiyuan
Published: November 2022

Volatile hydrazine hydrate (HH) and non-volatile glucose (GLC) were used as n-type dopants to prepare thickness-insensitive MoOx HTLs in high performance OSCs.
SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine
Authors: Li Kunlun , Meza Guzman Lizeth G. , Whitehead Lachlan , Leong Evelyn , Kueh Andrew , Alexander Warren S. , Kershaw Nadia J. , Babon Jeffrey J. , Doggett Karen , Nicholson Sandra E.
Published: November 2022

Suppressor of cytokine signaling (SOCS) 2 is the critical negative regulator of growth hormone (GH) and prolactin signaling. Mice lacking SOCS2 display gigantism with increased body weight and length, and an enhanced response to GH treatment. Here, we characterized mice carrying a germ-line R96C mutation within the SOCS2-SH2 domain, which disrupts the ability of SOCS2 to interact with tyrosine-phosphorylated targets. Socs2R96C/R96C mice displayed a similar increase in growth as previously observed in SOCS2 null (Socs2−/−) mice, with a proportional increase in body and organ weight, and bone length. Embryonic fibroblasts isolated from Socs2R96C/R96C and Socs2−/− mice also showed a comparable increase in phosphorylation of STAT5 following GH stimulation, indicating the critical role of phosphotyrosine binding in SOCS2 function.
The ecological impact of plastic pollution in a changing climate
Authors: Chowdhury Gawsia Wahidunnessa , Koldewey Heather J. , Niloy Md. Nazmul Hasan , Sarker Subrata
Published: November 2022

Assessing three interlinked issues, plastic pollution, climate change and biodiversity loss separately can overlook potential interactions that may lead to positive or negative impacts on global ecosystem processes. Recent studies suggest that threatened species and ecosystems are vulnerable to both plastic pollution and climate change stressors. Here we consider the connectivity and state of knowledge between these three environmental issues with a focus on the Global South. Nine out of top ten Long-Term Climate Risk Index (CRI) (2000–2019) ranked countries are located within the Global South, yet research is focused in the Global North. A literature search for the top ten Long-Term Climate Risk Index (CRI) (2000–2019) ranked countries matched a total of 2416 (3.3% of global publications) search results on climate change, with 56 (4% of the global publications) on plastic pollution, and seven (7.7% of the global publications) on both climate change and plastic pollution. There is a strong correlation between the Global South and high biodiversity hotspots, high food insecurity and low environmental performance. Using Bangladesh as a case study, we show the erosion rates and sea level rise scenarios that will increase ocean-bound plastic pollution and impact high biodiversity areas. Poverty alleviation and promoting renewable energy and green practices can significantly reduce the stress on the environment. We recommend that these connected planetary threats can be best addressed through a holistic and collaborative approach to research, a focus on the Global South, and an ambitious policy agenda.
i(cm)z, a semi-analytic model for the thermodynamic properties in galaxy clusters: Calibrations with mass and redshift, and implication for the hydrostatic bias
Authors: Ettori S. , Lovisari L. , Eckert D.
Published: November 2022

Context. In the self-similar scenario for galaxy cluster formation and evolution, the thermodynamic properties of the X-ray emitting plasma can be predicted in their dependencies on the halo mass and redshift only. However, several departures from this simple self-similar scenario have been observed.

Aims. We show how our semi-analytic model i(cm)z, which modifies the self-similar predictions through two temperature-dependent quantities, the gas mass fraction fg = f0Tf1Ezfz and the temperature variation fT = t0Tt1Eztz, can be calibrated to incorporate the mass and redshift dependencies.

Methods. We used a published set of 17 scaling relations to constrain the parameters of the model. We were subsequently able to make predictions as to the slope of any observed scaling relation within a few percent of the central value and about one σ of the nominal error. Contextually, the evolution of these scaling laws was also determined, with predictions within 1.5σ and within 10 percent of the observational constraints. Relying on this calibration, we have also evaluated the consistency of the predictions on the radial profiles with some observational datasets. For a sample of high-quality data (X-COP), we were able to constrain a further parameter of the model, the hydrostatic bias b.

Results. By calibrating the model versus a large set of X-ray scaling laws, we have determined that (i) the slopes of the temperature dependence are f1 = 0.403 (±0.009) and t1 = 0.144 (±0.017); and that (ii) the dependence upon Ez are constrained to be fz = −0.004 (±0.023) and tz = 0.349 (±0.059). These values, which are inserted in the scaling laws that propagate the mass and redshift dependence to the integrated quantities, permit one to estimate directly how the normalizations of a given quantity QΔ changes as a function of the mass (or temperature) and redshift halo in the form QΔ ∼ MaMEzaz ∼ TaT EzaTz, which is in very good agreement with the current observational constraints. When applied to the best spatially resolved data, we obtained estimates of the hydrostatic bias b that are lower than, but still comparable with, the results obtained by other, more standard, means. We conclude that the calibrated semi-analytic model i(cm)z is able to make valuable predictions on the slope and redshift evolution of the X-ray scaling laws, and on the expected radial behavior of the thermodynamic quantities, including any possible hydrostatic bias.
Preliminary modelling of power losses in roller chain drive: application to single speed cycling
Authors: Lanaspeze Gabriel , Guilbert Bérengère , Manin Lionel , Ville Fabrice
Published: November 2022

A quasi-static chain drive model is proposed. This model, consistent with single speed cycling application, applies to simple two sprocket drives. The kinematics of the transmission is determined, including the capture and release positions of the rollers and the influence of the polygonal effect. The tensions into the links and the contact forces (between rollers and sprocket) are then calculated based on the results of the kinematic analysis. Both chain strands are assumed to be straight and their tension are considered as imposed. An estimate of the roller displacement is proposed using existing studies on the relationship between loading conditions and roller positions along the sprocket tooth profile. The presented model, is then used to assess the contribution of both meshing and roller motion on the global efficiency of the drive. Calculations show that the magnitude of both loss sources is similar for a wide range of gear ratios and loading conditions. According to the presented results, the relative motion between the rollers and the sprocket tooth profile should be considered in future studies dedicated to chain drive efficiency.
Enhancement Student Achievement on Basic Chemistry Course Through Assessment as Learning Implementation
Authors: Muchlis  , Agustini Rudiana , Dwiningsih Kusumawati , Asih Findiyani Ernawati
Published: November 2022

This paper described student achievement on Basic Chemistry Course through assessment as learning implementation. The research method used one shot case study. Matter of Basic Chemistry Course consist of Stoichiometry, The Periodic Table and Chemical Bonding. The first implementation in the research was assessment as learning implementation on Stoichiometry Matter, then on the Periodic Table Matter and the last on Chemical Bonding Matter. The end of each implementation, students were given assessment. Based on result of assessment, student reflected his/her achievement to enhance their learning. The material learning consist of Lesson Plan, Worksheet and Guiding Book. Instrument of research was Sheet of Student Achievement Test. Based on result of research showed 89.7% of students tended to enhance and 10.3% students tended to go down in student achievement.
Family Education and Weaving Tradition
Authors: Terry Hetreda , Pelealu Aldegonda E. , Umbase Ruth S. , Pane Lindon R.
Published: November 2022

This study aims to describe the role of family education in preserve the weaving tradition by local community at Romean Village, Tanimbar Island. The method employed in running the research was qualitative descriptive method, while collection data using observation, interview and documentation.Furthermore, due to analyse we did it through interactive session and repeatedly until it’s done and the data become saturated. The result shows that the family education (parents) have an important role in educate and bequeath the tradition of weaving for their next generation. Family become the first environment for children to be taught about nice and kind second nature as a part of generation. Along with that, the family education in order to maintain and nurture weaving tradition admittedly being a frontline to be teach to youngsters. Parents have an obligation to introduce their own tradition whatever it is and also what they can do as a part of community members, henceforth the children would have a sense of belonging of a tradition from their ancestors since their early ages. The young generation will take responsibility and sustain the weaving tradition as forefather legacy.
Measuring the Urgency of Pancasila Student (Pelajar Pancasila) Profiles; Prospective Primary Education Teacher’s Perspectives
Authors: Sinaga Serlina Boru , Marpaung Roberto W.
Published: November 2022

Pancasila student profiles launched by the government through the Ministry of Education, Culture, Research, and Technology were aimed at formulating the main goal of national education in disruptive era. The objective of this research was to describe the perspective of primary teacher education students on Pancasila Student Profiles. The research design used was descriptive research design with qualitative method. The study was conducted in a state university in Papua as the barometer of education quality in rural and border area. There were 50 students investigated and most of them are in the first year college. Questionnaire, interview, observation and documentation were used as the techniques of data collection. The data were analyzed by employing data analysis techniques such as; data reduction, data display, and drawing conclusion. The results showed that Pancasila Student profiles are important for prospective teachers of primary education. However, most students have no knowledge and understanding about the profiles. All education policy makers and practitioners must work together by hand-in-hand to socialize the profiles either at schools or at universities.
The Educational Curriculum Reform in Indonesia: Supporting “Independent Learning Independent Campus (MBKM)”
Authors: Utami Yuni Putri , Suswanto Budyi
Published: November 2022

Curriculum reforms in Indonesia are now allowing students to become independent learners in the sense that they are central to the teaching and learning process. This change is a new requirement for teachers and school lecturers to support students with educational strategies that allow them to actively participate in the learning process. This is in line with the new curriculum idea for self-study and independent campuses launched by the Ministry of Education, Culture, Sports, Science and Technology to better prepare students to face the challenges of the world of education. Due to this change, Indonesian English teachers are strongly encouraged to overcome the challenges faced by their students and find the best teaching methods to achieve the best learning outcomes. However, teachers and students have different views on the implementation of English language teaching, so the results do not always meet expectations. Thus, this literature review discusses several issues related to English, including English for teaching, English strategies for teachers, independent self-study on campus, and issues of teaching English. Moreover, the main purpose of this article is to acknowledge to the reader that mainly teachers and students need English, because English is important for the development ofeducation in Indonesia.
The Obstacles of Elementary School Teachers for Applying Effective and Fun Learning in The New Normal in Selayar Islands Regency
Authors: Suhaeb Firdaus W. , Ahmadin  , Novita Sari Dian , Kaseng Ernawati S.
Published: November 2022

The purpose of this study is to describe and analyze the obstacles for elementary school teachers in implementing effective and fun learning during the new normal in the Selayar Islands Regency. The type of research in this article is descriptive using a qualitative approach. Data was collected through observation, participatory interviews, and documentation. Research informants were chosen deliberately, namely classroom teachers who applied effective and fun learning strategies. Validation of the data is done through the triangulation of sources to assess the credibility of the data. The results showed that the obstacles encountered by elementary school teachers in implementing effective and fun learning during the new normal were related to difficulties in managing the classroom where teachers were less able to guide, direct and guide all activities carried out by students with different characteristics. This is because during the new normal, there is a reduction in learning hours in class or school, namely face-to-face learning only lasts for 2 to 3 hours per day.
Use of the C4.5 Algorithm to Analyze Student Interest in Continuing to College
Authors: Lintang M. , Pandiangan N. , Hyronimus D.
Published: November 2022

Abstract. Higher education is one of the goals of several options when a student completes education in high school. However, not all students wish to continue their education in college. There are many reasons behind why students do not continue their education in college. Several factors that influence in this research include self-motivation, scholarships provided, parental support, ease of getting a job and academic competition. This study took a sample of 25 student data that will be used to find the most influential factors in continuing education in higher education. This study uses a data mining classification approach using the c4.5 method in making a decision tree. The results that can be concluded, a student has a high desire to continue his education in college because it will make it easier for them to get a job and the factor in getting an education scholarship.
Analysis of Student Satisfaction on Service Performance of Education Personnel at the Faculty of Social Sciences, Manado State University
Authors: Biringan Julien , Keintjem Maxi Ventje
Published: November 2022

The purpose of this study was to determine the level of student satisfaction who received the services of education personnel at FIS Unima in the fields of student affairs, academics, general affairs, and finance/employment. For processing and analyzing data in this study, two approaches were used, namely,the quantitative approach, which a descriptive approach to describe the data is obtained by researchers in the field. The point is that before the data is interpreted qualitatively, it is presented in the form of percentage tables, then the existing data will be analyzed qualitatively with descriptive statistical analysis, total sampling of all employees in FIS, and student samples taken randomly stratified. The results of the study indicate that students show very high satisfaction with the services provided, where employees work to show real performance in providing services, discipline in entering the office and doing work, perseverance in work, commitment to decisions, and fairness in providing services to students by not discriminating attitudes and behaviors.
Implementing Project-Based Learning in a Hybrid Setting: The Effectuality of the EFL Students’ Reading Comprehension
Authors: Assiddiq Muhammad Azwar , Sasmayunita
Published: November 2022

Moving face-to-face reading class to a hybrid learning during the COVID-19 pandemic constructs challenges for EFL teachers. The EFL teachers must apply appropriate learning models in a hybrid setting. This current study aimed to examine the effectuality of project-based learning in a hybrid setting on the EFL teacher candidates’ reading comprehension. A quasi-experimental study was conducted for seven weeks to deal with the purpose. The participants were 50 students selected from an English Language Education Study Program at a public university in eastern Indonesia where the researchers had been working as a lecturer. Twenty-five participants joined the experimental class, and the rest entered the control class. The students in the experimental group were taught reading comprehension using project-based learning in the form of hybrid learning. In contrast, the conventional method in a hybrid setting was applied to teach the students reading comprehension in the control group. The reading comprehension test was distributed to both groups as pre-test and post-test. Based on the result of inferential analysis through SPSS, it was found that the implementation of project-based learning in a hybrid setting benefited the EFL teacher candidates in terms of improving their achievement in reading comprehension
Challenges in the Implementation of the “Jalur Khusus” Concept in the Draft Indonesian Criminal Procedure Code
Authors: Mahardhika Vita , Astuti Pudji , Rusdiana Emmilia , Hikmah Nurul , Ahmad Gelar Ali
Published: November 2022

Efforts to reform the criminal procedural law continue to be carried out, by introducing many new concepts such as preliminary examination, expansion of the opportunity principle to the concept of a “jalur khusus” which is similar but not the same as the plea-bargaining concept applied in common law countries, especially the United States. The concept of this “jalur khusus” is understood to encourage the creation of an effective and efficient criminal justice system so that the principles of simple, fast, and low-cost justice can be realized. Of course, this new concept still needs to be studied its advantages and disadvantages. By using normative juridical research methods, this study aims to examine the challenges in applying the concept of “jalur khusus”s as stipulated in the RKUHAP. From this research, it can be seen that in addition to the ambiguity of the proceedings and the provisions on the maximum limit of punishment, what needs to be criticized is the parameters of the judge's belief in determining the truth of the defendant's confession and also the unregulated role of the victim in the “jalur khusus” mechanism.
Empowering of Small Businesses in Community Development in Merauke, South Papua Crocodile’s Leather Craftsman
Authors: Syukron Nurkholis , Tambaip Beatus , Fuad Adam Aenal , Haris Umiyati
Published: November 2022

This study discusses the empowerment of crocodile skin handicrafts by the Department of Cooperatives, Industry and Trade of Merauke Regency. This study aims to determine the efforts to empower the Merauke Regency Industry and Trade Cooperatives Service towards crocodile skin craft business in Merauke Regency. This study uses a descriptive method with a qualitative approach. Determination of informants using purposive sampling technique. Data was collected through observation, direct interviews and documentation. The results showed that the efforts to empower the crocodile skin craft business by the Department of Cooperatives, Industry and Trade of Merauke Regency were not optimal. This refers to the empowerment that has been carried out by the Department of Cooperatives, Industry and Trade of Merauke Regency which is generally still oriented to the routine work of the government. Such conditions ultimately hampered the process of empowering crocodile skin crafts on Bumi animha Merauke. The researcher recommends the Department of Cooperatives, Industry and Trade of Merauke Regency to carry out intensive socialization of the use of galze and coloring techniques as well as the use of information, communication and technology to distribute crocodile skins, synergize with craftsmen to strengthen business independence and for crocodile skin crafts it is better to start actualizing themselves in improve the ability to find and take advantage of opportunities so that the sale of crocodile skin products is more easily accessible to the market.
The Role of Social Media In The Election of Regional Heads in South of Solok
Authors: Gugule Hamdi , Mesra Romi , Fathimah Siti
Published: November 2022

The political arena in South of Solok has recently spread to social media. There are many posts that show the goodness and performance of regional head candidates. When viewed from the posts, especially in the South of Solok facebook group, there are very many people who write statuses about this candidate for regional head and in the comments column there are also a lot of comments or there are also a lot of debates, both with rhetoric for the progress of South Solok and some are clear. -Obviously support one of the candidates. This study aims to the role of social media in the election of regional heads in south of Solok. This study used qualitative research methods. The results of the study reveal: media for recruiting candidates, showing the existence of success teams, promotional media, communication media with voters, and means to gain support and be elected in the pilkada.
Legal Analysis of Sibling Forbidden Relationships (Incest)
Authors: Kasmawati Andi , Bakhtiar
Published: November 2022

This research is qualitative, and the type of data source is secondary data, so the data collection technique used in this research is documentation. The analysis was carried out using content analysis data analysis. From this research, it was found that the law that regulates marriage Undang-Undang Nomor 1 Tahun 1974 tentang perkawinan sebagaiman telah diganti dengan Undang-Undang Nomor 16 Tahun 2019. In addition, marriage is also described in Kompilasi Hukum Islam Law article 39-point (1) letter a. In addition, civil law also regulates the prohibition of marriage which is explained in Article 30 of KUH. Thus, both in religious law and state law, inbreeding does not provide space at all. According to Islamic law, incest is strictly prohibited or forbidden in the religion as stated in the QS. An-Nisa: 22, 23 who should not and may not marry. By customary law, it is strictly forbidden to have incest or incest because it violates the norms and values that apply in society.
Purchase Intention of Second-Hand: A Case Study of Generation Z
Authors: Kawulur AF , Sumakul Grace , Pandowo Aditya
Published: November 2022

a lower price than new products. The increase in second-hand purchases cannot be separated from Generation Z consumers, who also turn out to be consumers who buy second-hand products where they started buying second-hand three years ago. Generation Z, generally Women, like purchasing secondhand goods, especially clothes, with online purchases. In terms of Generation Z's purchase intentions, orientation toward low prices, the desire to appear unique, nostalgia, and trust are the determining factors for Generation Z to make second-hand purchases. Meanwhile, the bargaining factor usually done in buying and selling is not a factor for Generation Z to buy used goods.
Ramang The Legends of Makassar Football Union (An Overview of Sports History)
Authors: Bustan  , Jumadi  , Najamuddin  , Subair Ahmad
Published: November 2022

This study aims to determine the Makassar Football Association, which is headquartered in Makassar, South Sulawesi province. The Makassar Football Association was founded on November 2, 1915 which at that time was still a football association called Makassar Voetbal Bond. Based on the historical background of his achievements, Makassar Voetbal Bond features male players in the elite ranks of Dutch East Indies football such as Sagi and Sangkala as reliable players who at that time were highly respected by Dutch players. The Makassar Football Association is known as the birthplace of young and talented football players. Talented young players include Ramang, Suardi Arlan, Nursalam and Maulwi Saelan. The player emerged and triumphed in the 1950-1970 era. Ramang is a football legend who came from PSM which at that time was still called Makassar Voetbal Bond. Ramang began strengthening the Makassar Football Association in 1947. This study uses a qualitative approach with historical methods through heuristics, criticism, interpretation, and historiography.
Traditional Fishermen in The Context of Modernization: A Case Study in Holimombo Jaya Village, Buton Regency, Southeast Sulawesi Province
Authors: Malihu La , Ahmadin  , Subaer Ahmad
Published: November 2022

This study analyzes the existence of traditional fishermen in the context of modernization in Holimombo Jaya Village, Pasarwajo District, Buton Regency, Southeast Sulawesi Province. The aims of this study is to answer a key question, whether modernization has caused a cultural lag in traditional fishermen; or have they succeeded in innovating and adapting to the values of modernity so that they still exist and achieve sustainable progress? Using the historical method through four stages of work, namely: heuristics, criticism, interpretation, and historiography. The results show that modernization has brought significant changes in the socio-economic life of the fishing community of Holimombo Jaya. There is no patron-client relationship as is often found in fishing communities in Indonesia. All fishermen have their own fishing gear, operated by themselves without involving a third party. In this way, income becomes evenly distributed so that fishermen are able to get out from absolute poverty trap. They reject the use of fishing gear that has the potential to damage environmental sustainability and the balance of the fishery ecosystem. They also prioritize the interests of consumers by using only ice in fish preservation. They refuse the use of preservatives that endanger health such as formalin and borax.
The Church and Politics of Early 20th Centuries in Minahasa
Authors: Burdam Yohanes , Dasfordate Aksilas , Edi Winoto Darmawan , Lely Merly Sendy
Published: November 2022

This study aims to explain the presence of the Indische Kerk (church) of the Dutch colonial government in Minahasa, identify the problems faced by the Indische Kerk and efforts to address them in Minahasa, and analyze politics and political education in Minahasa, as well as the impact of colonial politics on the process of church ministry in Minahasa. This study employs both the structural method of Lloyd (1978) and the explanation of the fact theory of Tilly (1978). Research and discussion revealed that the presence of the Indische Kerk in Minahasa is connected to the rule of the Dutch colonial administration following the bankruptcy of the VOC trade partnership on December 31, 1799. Consequently, NZG cannot refinance its work in Minahasa. The Dutch colonial administration utilized the church door, the Indische Kerk, to exert control over the Minahasa people. However, some Minahasa-educated individuals who comprehended the politics of the Dutch colonial administration and who collaborated with the Indische Kerk to control the Minahasa people opposed the colonial church's engagement in establishing an autonomous church in Minahasa.
Broadening History; The Use of Psychohistory in Attempt to Provide Historical Explanation
Authors: Listyaputri Dinar Rizky , Nasution  , Sumarno  , Wisnu
Published: November 2022

For decades, historians have been divided and stood on different polarities of history. Half of them described history as it consists of facts and a series of scientifically proven events and some were insisting that history has a special relationship with human life that could be explained from various perspectives. Ranke emphasized the importance of preventing historians from including their prevailing theories and relying on primary sources. Meanwhile, Robinson and Annales historians were against the dominance. They proposed the use of social science and other points of view to define histories differently from what Ranke did (which mostly is dominated by political factors). This paper aims to explain historiography’s development and to introduce the psychological factor as one of the aspects of historical explanation. The research is a kind of qualitative research that uses the literature study. The research found that historiography has been developed from a single-factor style to multi-view historiography. Psychohistory is one of the rising fields to be studied.
Contemporary Agreement Law Discussing Electronic Agreements in Electronic Media Transactions on The Aspect of Their Legitimacy
Authors: Hanafie Nurharsya Khaer , Herman  , Gani Andika W. , Firmansyah  , Amirullah
Published: November 2022

This study analyzes the validity of the electronic agreement. The purpose of this study specifically will dissect and analyze aspects of the agreement in the Civil Code and explore the legality of electronic agreements in the practice of electronic media transactions. The research method used is normative juridical research, because in parsing and discussing the use of applicable regulatory instruments along with library materials as primary sources in research, the research approach is by taking a statutory approach, by looking at the phenomenon of technological developments, it is also necessary to look at the regulatory instruments by analyzing regulations related to contract law according to positive law as the foundation in conducting electronic agreement practices. Based on the results of the study, it can be concluded that the electronic agreement already has adequate legal instruments. 19 of 2016 concerning information and electronic transactions. Therefore, the legal structure used to make electronic agreements can be applied in Indonesia, although in the author's opinion, there are still some regulatory improvements in the midst of the development of virtual transactions in order to provide legal certainty to the public.
Decision-Making of Women Leaders in Government Organizations
Authors: Mokat Jetty , Sendouw Recky H. E. , Mantiri Jeane , Rantung Margareth I. R.
Published: November 2022

This study aims to determine how the decision-making style of women leaders in government organizations in Manado City. Using a descriptive qualitative approach with the type of case study. Data collection is done through observation, interviews, and documents with triangulation. Data analysis uses an interactive model from Miles and Huberman. The results of the study show that in making decisions, female leaders use normative rules as a reference for action. In general, female leaders, at certain times try to give directions/instructions, involve subordinates, and there a delegation of tasks. Women leaders also have a firm attitude, tend to be strict, very disciplined, and dare to act in very urgent situations to enforce rules for the effectiveness of carrying out their duties. But at a certain time, they can act very meticulously, informatively and communicatively, also responsive and flexible, gentle, friendly, and considerate to subordinates but still authoritative, so that the instinct of a mother radiates in female leaders.