bluuebunny/crossref_metadata_2025 huggingface dataset:
Memoria y fotografía doméstica, narrativa de la vida familiar en la era digital
Authors: Fuentes Franco Leticia
Published: October 2022

Este documento pretende estudiar el álbum de familia como memoria y los cambios que ha experimentado por la evolución de los medios en los que se depositan los registros hoy en día. Para tal fin, se plantea un breve recorrido sobre los conceptos y los procesos de la memoria desde la psicología, la filosofía y una aproximación a la memoria colectiva desde la sociología. Una vez planteado lo anterior, se hace una reflexión sobre el álbum familiar, y su trascendencia como documento de memoria social, para finalmente esbozar algunos puntos de vista sobre los cambios en el uso y consumo de las fotografías domésticas a partir de su almacenamiento en la “nube” [1] y su consumo a través de las redes sociales.

[1] La nube es el nombre que comúnmente se le da al servicio de almacenamiento de datos en servidores localizados en la red. Esta modalidad permite subir, abrir, modificar o usar programas y archivos a través de una conexión sin la necesidad de que se encuentren en el almacenamiento de un dispositivo en específico.
The Relationship between Liquidity Risk Management and Commercial Bank Performance: Evidence from the Western Balkans
Authors: Kalimashi Albina , Ahmeti Skender , Aliu Muhamet
Published: October 2022

The current study examines the relationship between liquidity risk management and the performance of commercial banks in the Western Balkans between 2015 to 2020. This relationship is examined by using secondary data from the financial statements. Financial performance is measured by return on assets, equity and net interest margin. Liquidity risk is represented by the quick ratio, current ratio, loan-to-deposits ratio, loan-to-assets ratio, cash and investment-to-deposit ratio, capital adequacy and interest coverage ratio. The Ordinary Least Squares model was used to process the data. The study's findings show that return on assets has a negative relationship with the current ratio but a positive relationship with loans-to-total deposits, cash plus investments-to-total deposits and capital adequacy ratio. Return on equity has a negative relationship with the quick ratio and interest coverage ratio but a positive relationship with the current ratio, loans-to-total assets and cash plus investments-to-deposits ratio. Net interest margin is negatively related to loans-to-total deposits, capital adequacy interest coverage ratio and positively related to loans-to-total assets. These findings have implications for Western Balkan banks’ variables use to manage liquidity risk. The findings of the study are significant as they can be use to enhance liquidity risk management by influencing performance indicators for Western Balkans bank.
A KÖNYVTÁRAK ÚJ INNOVÁCIÓS ELEKTRA könyvtárak új innovációs elektronikus szolgáltatási rendszere
Authors: Ferenc Zalán Iszály
Published: October 2022

Kutatási témám „Elektronikus könyvtári szolgáltatások a 21. században”, melynek keretében kiemelt célom volt annak elősegítése, hogy a könyvtáraknak ne „csak” a kultúra, a tudomány megőrzésében, közvetítésében legyen aktív, meghatározó szerepe, hanem fokozzák részvételüket a kutatásban, az innovációban, az egyetemi Startup ötletek felkarolásában, megvalósításában, ezáltal a rendszer képes legyen a könyvtárak fenntarthatóságát segíteni, esetleg biztosítani. A tapasztalatok alapján, azok felhasználásával kidolgoztam egy „Új Webkettes innovációs könyvtári rendszert”, az UnInLib-et (University Innovation Library System). E tanulmányban ismertetem a következőket: Kutatási előzmények, a kutatás fontossága, jelentősége, szükségessége, Az UNINLIB rendszer főbb elemei, alprojektjei: A WIKT rendszer, a Startup kurzus, a Könyvtári Coworking, a Startup Kiállítás, a Startup Konferencia, a Startup Tábor, a GenILib (General Innovation Library) alprojekt. Továbbá a rendszer felhasználhatósága, megvalósítási lépések, az Innov Kutatóintézet, a Találmány (szabadalom). Az összegzésben kiemelem az Uninlib rendszer előnyeit, lehetőségeit, megvalósítási színtereit, szerepét a hazai és a nemzetközi könyvtári innovációban.
L’italianité liquide chez Antonio D’Alfonso et Filippo Salvatore
Authors: Felice Maura
Published: October 2022

Cet article se propose d’analyser les lieux de la migration dans les recueils de poèmes d’Antonio D’Alfonso (L’autre rivage, 1987) et de Filippo Salvatore (Terre e Infiniti, 2012). Les espaces habités par les poètes italo-canadiens deviennent liquides, leur discours identitaire n’y prend pas corporalité ou nationalité, au contraire, il se dissout. Au quotidien, l’énergie mobile des lieux « migrants » est la métaphore d’une condition identitaire qui veut traverser les frontières en longueur et en profondeur, pour tout ce qui touche à la sphère du souvenir, du voyage, du retour, du départ, du vagabondage – que ce soit à Guglionesi ou à Montréal, à travers le fleuve Biferno ou le Saint-Laurent, l’Adriatique ou l’Atlantique. Le fait de se baigner dans le panta rhei (toutes les choses coulent, tout passe) réveille la sensibilité des poètes : c’est ce bain qui régénère le moi, c’est ce qui lui donne l’énergie de se reconstruire autrement, différemment, d’acquérir une dimension universelle. Les gouttes d’eau, de sang et d’encre alimentent la construction d’une identité fluide et d’un nouveau sens de la citoyenneté.
Adaptacja miasta Warszawa do koncepcji smart city w oparciu o model odporności (resiliency model)
Authors: Baran Małgorzata , Kłos Monika , Marchlewska-Patyk Karolina
Published: October 2022

Koncepcja smart city, stanowiąca następstwo doktryny zrównoważonego rozwoju i zmian technologicznych, w ciągu ostatniego dziesięciolecia zyskała popularność na arenie międzynarodowej. Przeprowadzona dyskusja literatury światowej wskazuje na konieczność intensywnych działań, zarówno w obszarach nauki, jak i praktyki gospodarczej, na rzecz wdrażania, monitorowania i rozwoju koncepcji smart city.

Celem artykułu jest wyjaśnienie specyfiki koncepcji smart city na podstawie systematycznego przeglądu literatury oraz identyfikacja procesu adaptacji Warszawy do koncepcji smart city.

W publikacji wykorzystano metodykę przeprowadzania systematycznego przeglądu literatury w zakresie rozwoju koncepcji smart city oraz funkcjonujących modeli inteligentnych miast. Analiza z wykorzystaniem elementów studium przypadku została przeprowadzona na podstawie dostępnych raportów, rankingów i oficjalnych dokumentów miasta Warszawy. W efekcie zaprezentowana została charakterystyka miasta wskazująca na stopień rozwoju miasta Warszawy jako miasta inteligentnego. Analiza wyjaśnia mechanizmy realizacji przedsięwzięć typu smart w Warszawie, dając jednocześnie podstawy do wskazania modelu odporności miasta jako modelu adaptacji adekwatnego dla tego miasta.

Podjęte przez autorki rozważania ukierunkowane na rozwój koncepcji smart city, zwieńczone propozycją modelu inteligentnego miasta, ujawniają perspektywę badawczą skoncentrowaną na polskich miastach.
Zastosowanie kart kontrolnych do monitorowania zmian na rynku kompetencji pracowniczych
Authors: Szafrański Maciej , Stachurski Tomasz
Published: October 2022

Celem artykułu jest opracowanie i zweryfikowanie innowacyjnej metody monitorowania rynku kompetencji stanowiącej składową zarządzania kompetencjami. Sprawne, bieżące uzupełnianie wiedzy o kompetencjach, które powinny być wymagane w organizacjach, jest ważne ze względu na dużą zmienność wymagań kompetencyjnych. W badaniach wykorzystano metodę kart kontrolnych, które zazwyczaj są stosowane w monitorowaniu procesów produkcyjnych w celu zapewnienia jakości. Zastosowana implementacja stanowi innowację w badaniu nad kompetencjami. Wyniki badania odniesiono do wymagań dotyczących wybranych kompetencji miękkich na rynku kompetencji. Wybór tylko jednego regionalnego rynku kompetencji, zawężonego do wybranych wymagań kompetencyjnych stanowi ograniczenie badań. Wprowadzone zawężenie jest jednak zdaniem autorów uprawnione na etapie opracowania i wstępnej weryfikacji metody, która powinna być doskonalona w dalszych badaniach. Przedstawione w opracowaniu rozwiązanie ma praktyczne zastosowanie dla kadry zarządzającej organizacji w poszczególnych jej obszarach funkcjonalnych. Może na przykład stanowić przydatne narzędzie HRM.
Donuts for weight loss? A norovirus outbreak associated with a bakery in the Australian Capital Territory
Authors: Allen Keeley , Greenville Felicity , Marmor Alexandra , Waters Natasha , Wansink Victoria , Hudson Lyndell , Pingault Nevada
Published: October 2022

Background An outbreak of gastroenteritis was investigated following complaints of illness after eating donuts from a food premises in the Australian Capital Territory (ACT). Methods Food poisoning complainants and contacts were surveyed using a standard gastroenteritis questionnaire including menu items from the food premises. Descriptive analyses were performed on data collected for all responses. A case-control study was conducted for a group of 140 people at a catered function. Food safety inspections were conducted with food and environmental samples tested at the ACT Government Analytical Laboratory. Stool specimens were collected from cases who were ill at the time of interview. Neither active case finding, nor viral testing of food or environmental samples, could be conducted. Results Three hundred and one people were surveyed, and 215 individuals (71.4%) reported vomiting and/or diarrhoea following consumption of a donut purchased from the business over a five-day period. All ill respondents reported eating a donut. The medians of incubation period and illness duration were 34 hours (interquartile range, IQR: 29–42 hours) and 48 hours (IQR: 29–72 hours) respectively. Diarrhoea, vomiting and abdominal pain were the most commonly reported symptoms. Eight out of 11 specimens collected from ill individuals were positive for norovirus. For the case-control study, data from 59 attendees were collected, with an attack rate of 46% (27/59). Eating any kind of filled donut was associated with a person becoming ill (odds ratio: 10.4; 95% confidence interval: 1.18–478.13). No single flavour was identified as the likely source of infection. Elevated levels of coliforms were present in two samples of donut filling obtained during the food safety inspection. Conclusion Donuts are a novel vehicle for norovirus infection. This implicated pathogen, plus evidence collected at the food premises suggestive of faecal contamination, indicates the source of this outbreak was likely an ill food handler. The findings of this outbreak highlight the importance of excluding food handlers from work while ill. While this was one of the largest foodborne outbreaks investigated in the ACT, the true extent of illness remains unknown. Active case finding should be pursued to determine the magnitude of outbreaks.
COVID-19 Pandemic: A Remedial Measure Through Convalescent Serum
Authors: Abbas Shahzada Nadeem , Rauf Umber , Saleem Afshan , Saleem Natasha , Basheer Tayyba , Yaseen Sidra , Irfan Nida , Naushad Asif
Published: October 2022

An acute respiratory syndrome Corona Virus 2 has affected humanity throughout the world. Scientifically, Corona Virus 2 is known as SARS-COV-2 which is abbreviated as COVID-2019. China was the first victim of this outbreaks in December 2019 [1] which was later recognized as pandemic on March 11, 2020 by World Health Organization (WHO) [2,3]. At the time of this writing, about 8.75 million individuals of 188 countries [4] have been effected by COVID resulting in 463000 deaths primarily, corona virus communicates from one body to another body through close contacts via droplets produced by sneezing, coughing or taking by infected badly within a buffer zone of 3 to 6 feet [5,6,7]. These droplets fall onto a surface and can survive up to 72 hours [8]. Various studies have proved that droplets may travel up to 37 feet by an uncovered cough [9,10,11]. Corona virus is not an airborne, however it may transport through respiratory droplets during talking and breathing [12].
Spatial Patterns of LRTI among Children in Lahore
Authors: Manaf Shaista , Butt Dr. Ibtisam
Published: October 2022

Lower Respiratory Tract Infection (LRTI) is the leading global cause of morbidity and mortality in children of 1 month in developing countries. The aim of this research was to examine the spatial patterns of children under LRTI in Lahore, Pakistan. The records of all patients of LRTIs among children <5 years, admitted in the four different public sector hospitals of Lahore from 2017-2021 were analyzed. The collected data was processed and analyzed in SPSS 22.0 for the chi-square test (P<0.0.5), Multiple linear regression and ANOVA were calculated to assess the association of these variables. Town-wise distribution of diseases was mapped in ArcGIS 10.5. There were 2,609 pediatrics patients admitted and major cases in the year 2021. All the patients were distributed in four age groups, <2m, 2-12m, 13-24m, 25-60m. The most common diagnosis was Bronchopneumonia with (77.50%), Bronchiolitis (11.84%), Pneumonia (6.86%), and Bronchitis (3.79%). A significant increasing trend was found in Bronchopneumonia. In town-wise analysis, out of 2,609 patients, 977 patients were observed in Allama Iqbal Town. The peak season of the disease was seen in winter Dec-Feb. LRTI is a leading cause of childhood hospitalization in Lahore, Pakistan. These results may guide health authorities to determine where and when to effectively allocate resources for the prevention and control of LRTI.
Health Implications of Arsenic and Qualitative Deterioration of drinking Water from Underground Water Supply Lines of Lahore, Pakistan
Authors: Mehmood Hammad , Aslam Rana Waqar , Kakar Allauddin , Abbas Waqas , Javid Kanwal , Khalid Muhammad Burhan , Tahir Muhammad Hussain
Published: October 2022

The study is a comparative analysis of water quality among two variant areas of Lahore. There are several problems regarding drinking water facilities. Drinkable water can be contaminated due to various reasons. Thus, the study highlights infrastructural causes (material of pipes and outdated pipes) of water contamination. Wall City and Gulberg are the study areas of this research. Gulberg area is far much better in various terms as compared to the wall city. Under this study, four parameters were selected for water quality pH, Total dissolved solids, E.coli and Arsenic. There were 13 water samples collected from each study area by random sampling. Samples were tested on the latest footing in this field. All results validate the problematic statement and highlight severe health effects. The results of these four parameters were far above the water quality standards declared by World Health Organization. Causes of these severe results include the outdated water pipes that are being laid down for the past several decades, for example Wall City area, etc. Results also depict low values in the Gulberg area which is recently developed as compared to the wall city. The comparative study also attests problem statement of the study.
Assessment and Validation of Land Surface Temperature (LST) Dynamics using Geo-spatial Techniques in Dera Ghazi Khan City, Pakistan
Authors: Khurshid Mareena , Shirazi Safdar Ali
Published: October 2022

The integrated practice of remote-sensing and GIS techniques provides an active tool for assessment of spatial and temporal variability of land features. Based on literature, it can be suggested that various studies over the recent years have been carried out to explore the potential of geospatial techniques and were found highly efficient to understand the interdependency of landscape changes, land surface temperature changes (LST) and creation of Urban Heat Island (UHI) in major cities around globe. The current research was conducted in Dera Ghazi Khan, Punjab- Pakistan which is located at latitude 30.04587 N and longitude 70.64029 E. The Landsat 8 TIRS and OLI images were obtained free of cost from USGS e-data portal. These images have already been rectified to WGS-1984-UTM-Zone_43N. The meteorological data file (MTL) for Dera Ghazi Khan- contains the study was acquired from Pakistan Meteorological Department. As per results vegetation cover has been decreased up to 15 % from 2001 to 2021, which was directly affecting the land surface temperature. It has been observed that LST derived from the satellite was closely matched with ground climatic data; there was a mere temperature difference of 2°C to 3°C. It is concluded that LST was negatively correlated with vegetation cover of the area under study. It is suggested to implement road map as provided in Dera Ghazi Khan Master Plan-2021 in order to have a control on unplanned landscape changes, urban evolution and rapid population growth.
Blind Image Deblurring Using Laplacian of Gaussian (LoG) Based Image Prior
Authors: Zaka Sofia Sofia , Majeed Muhammad Nadeem , Dawood Hassan
Published: October 2022

Blind image deconvolution, a technique for obtaining restored image as well as the blur kernel from an inexact image. This research uses spatial characteristics to tackle the problem of blind image deconvolution. To work, the proposed method does not necessitate prior information about the blur kernel. Many applications, such as remote sensing, astronomy, and medical X-ray imaging, necessitate blind image deconvolution algorithms. This study used the maximum a posteriori (MAP) paradigm to create a new blind deblurring approach for removing blur from images. In beginning, we employed a Laplacian of Gaussian (LoG)-based image before regularising the gradients of an image. In the second phase, we used an operator known as the Iterative Shrinkage Thresholding Algorithm (ISTA) to cope with the non-convex challenge that develops during the entire deblurring procedure. Finally, we compared our method to several well-known methods in terms of quantitative and qualitative qualities, and we were able to determine which strategy was the most effective. Our findings show that the strategy we propose outperforms the others by a large margin.
Diversity and Conservation of Avian Fauna in Daphar Forest Sanctuary, Mandi Bahauddin, Pakistan
Authors: Yasmeen Roheela , Ali Ehtisham , Amjad Muhammad , Bokhari Syeda Shazia
Published: October 2022

Biodiversity is representative of a healthy ecosystem. Anthropogenic activities, including habitat degradation, hunting, and fragmentation, are major circumstances which results in species extinction. The present study was conducted to explore avian fauna and role of Daphar Forest Sanctuary, Mandi Bahauddin, Pakistan, in its conseration. Study was carried out for 12 months, and 12 visits were made during 1st January 2020 – 31st December 2020. The visits were paused during periods of rain or high wind. Sampling was done by direct count method. A total of 2999 avian population were observed during the study. An overall population was composed of 12 orders, 20 families, 28 genera, and 32 species. Relative Abundance was calculated highest for family Sturnidae, 12.94% (N = 388) of birds, and order Passerine 54.95% (N = 1648). Simpson Diversity index (SDI) value was 0.95, Shannon Weiner Diversity Index value was 3.224 that, showed high diversity of avian fauna. However, evenness was 0.78, which showed an even distribution was found among birds population. It was noticed that Sanctuary faces drastic pollution which results in complications for the native wildlife. It was concluded scientific activities and researches were legalized in the respective wildlife sanctuary so that more information is gathered about the wildlife thriving in these areas.
Emotional Intelligence, Motivation and Dysfunctional Attitude among Patients with Substance Use: Cognitive Behavior Therapy
Authors: Naz Irum , Naz Anam
Published: October 2022

he study explores the significant predictive relationship between emotional intelligence, motivation, and dysfunctional attitude among substance use patients with the role of cognitive behavior therapy. The sample was comprised of 150 addictive patients. Among 150 patients, 40 were selected for intervention. The sample was divided into two groups of 20 each in the experimental and controlled groups. Participants were selected using a purposive sampling technique from Poly Clinic Jhelum, Punjab, Pakistan. To estimate the constructs following scales were used Trait Emotional Intelligence Questionnaire-Short Form Scale, Situational Motivation Scale, Dysfunctional Attitude Scale Short Form and Drug Abuse Screening Test all in Urdu. Patients with a high level of dysfunctional attitude were selected for intervention. For each participant, 12 sessions were planned. The statistical calculations were done using Statistical Package for Social Sciences(V-26). Regression analysis confirmed that emotional intelligence and motivation is a significant predictors of dysfunctional attitudes in substance used patients [R²=.066; F (2, 147) = 5.198, p<.01] with 6.6% explained variation in the dysfunctional attitude due to emotional intelligence and motivation. The effectiveness of cognitive behavior therapy was also evident with the experimental groups mean score of emotional intelligence (M=78.6, M = 169.00), motivation (M=58.1, M = 92.10) and dysfunctional attitude (M=61.1, M = 26.00) pre and posttest scores. It indicates that Cognitive Behavior Therapy was effective in the treatment of drug addicts to deal with lower levels of motivation and emotional intelligence as well as higher dysfunctional attitudes.
For emotional intelligence, results showed that there is change in mean score of experimental groups (M=78.6, M = 169.00) For motivation, results showed that there is change in mean score of experimental groups (M=58.1, M = 92.10). For dysfunctional attitude, results showed that there is change in mean score of experimental groups (M=61.1, M = 26.00) which indicate that Cognitive Behavior Therapy was effective in treatment of drug addicts to deal with lower levels of motivation and emotional intelligence as well as higher dysfunctional attitude.
Critical Review of Blockchain Consensus Algorithms: challenges and opportunities
Authors: Tahir Muhammad , Sardaraz Muhammad , Aziz Usman
Published: October 2022

Blockchain is a distributed ledger in which transactions are grouped in blocks linked by hash pointers. Blockchain-based solutions provide trust and privacy because of the resistance to the inconsistency of data and advanced cryptographic features. In various fields, blockchain technology has been implemented to ensure transparency, verifiability, interoperability, governance, and management of information systems. Processing large volumes of data being generated through emerging technologies is a big issue. Many researchers have used Blockchain in various fields integrated with IoT, i.e., industry 4.0, biomedical, health, genomics, etc. Blockchain has the attributes of decentralization, solidness, security, and immutability with a possibility to secure the system design for transmission and storage of data. The purpose of the consensus protocols is to keep up the security and effectiveness of the blockchain network. Utilizing the correct protocol enhances the performance of the blockchain applications. This article presents essential principles and attributes of consensus algorithms to show the applications, challenges, and opportunities of blockchain technology. Moreover, future research directions are also presented to choose an appropriate consensus algorithm to enhance the performance of Blockchain based applications
Development and Psychometric Properties of Harassment Tendency Scale
Authors: Mobeen Fouzia , Bano Dr. Zaqia
Published: October 2022

The aim of this research was to construct a native scale for harassment tendency and psychometric properties for the assessment of the Harassment tendency scale according to the cultural perspective of the Urdu language used. This indigenous scale can be used by psychologists, psychiatrists and even researchers for the general population to measure the tendency of harassment among males and females as well. Utilizing existent content and information from the literature research, the initial item pool of 150 items were created. Following the pilot research, 12 of the 138 expert-evaluated items were kept, including the eight aspects of harassment. Additionally, data from the sample of (N=340) people who completed this scale's final administration were gathered. Participants from educational institutions and local communities from different areas of Pakistan by using a self-reported questionnaire through convenient sampling. Rotated component matrix analysis shows, factors loading ranges from 0.402 to 0.641 of 97 items. The sample adequacy showed KMO=0.866 on 27 items (N=340) and factor loading loaded 8 factors. CFI value 0.909 with the significant model fit p<0.05 with appropriate model fit indices. HTS also conformed to good test-retest reliability (r=0.954, p=.000) at a 0.01 alpha level which is indicated the scale is a reliable measure for harassment tendency. A scale to measure Harassment tendency in the Urdu language is competently established with 27 questions and eight factors. Statistical Package for the Social Science volume 24 used for EFA (Exploratory Factor Analysis). AMOS (Analysis of a Moment structure) version 24 was used for CFA (Confirmatory Factor Analysis).
THE EFFECT OF WORKPLACE OSTRACISM ON ORGANIZATIONAL SILENCE AND WORKPLACE LONELINESS A STUDY ON HEALTHCARE WORKERS
Authors: ÖZİŞLİ Ömer
Published: October 2022

In the environment of changes in working life and competition, organizations employ their employees by interacting with different individuals. These employees contribute to their organizations by working with many colleagues and managers. This study aims to examine the mediating effect of workplace ostracism on workplace loneliness and organizational silence. Individuals working in health services in public institutions in the Marmara Region constitute the study group. The study data were collected using an online survey method. This study concluded that workplace ostracism has a positive effect on workplace loneliness. Workplace ostracism and workplace loneliness affect organizational silence positively. In addition, workplace loneliness has a mediating role in the effect of workplace ostracism on organizational silence.
Pergolide, Terguride and N,N'-spacer-linked Oligomers of Both Interact with 5-HT2A Receptors of Rat Tail Artery.
Authors: Křen V , Eich E , Pertz HH
Published: October 2022

Pergolide, terguride and N,N'-spacer-linked oligomers of both have been tested for their ability to interact with 5 hydroxytryptamine(HT)2A receptors of rat tail artery. Pergolide was a potent partial agonist (pEC50 7.5, Emax 55 %) and antagonized 5-HT-induced contractions (pKp 7.2). Pergolide dimer 3 with a p-xylene spacer between the indole nitrogens (N-1) displayed somewhat lower agonist potency than pergolide (pEC50 7.0, Emax 55 %, pKp 6.6). The contractile responses to pergolide and dimer 3 were antagonized by the 5-HT2A receptor antagonist ketanserin (pA2 9.4, 9.1). In contrast to pergolide dimer 3, pergolide dimers 5 and 9 with an alkyl and an aralkyl spacer between the piperidine nitrogens (N-6) lacked agonism and displayed low affinity at 5-HT2A receptors (pA2 < 5.5). Terguride behaved as an insurmountable antagonist of 5-HT (pA2 8.4). Oligomers of terguride showed 5 to 50-fold lower affinity. It is concluded that pergolide and terguride show a high affinity for 5-HT2A receptors, but dimerization (oligomerization) of both drugs fails to increase affinity.
Effect of Stobadine on Opsonized Zymosan Stimulated Generation of Reactive Oxygen Species in Human Blood Cells.
Authors: Pečivová J , Mačičková T , Číž M , Nosáľ R , Lojek A
Published: October 2022

To predict more precisely the effect of stobadine, a pyridoindole antioxidant agent, in the whole organism, we studied its effect on opsonized zymosan-stimulated free radical generation in whole blood, on superoxide generation in the mixture of PMNL : platelets (1:50), as well as on superoxide generation and myeloperoxidase release in isolated PMNL. Without stimulation, stobadine had no effect on reactive oxygen species (ROS) generation and myeloperoxidase release. Stobadine in a concentration of 10 or 100 micromol/l significantly decreased luminol-enhanced chemiluminescence in opsonized zymosan-stimulated whole blood. In concentrations of 10 and 100 micromol/l, it reduced myeloperoxidase release from isolated neutrophils. Stobadine significantly decreased superoxide generation in isolated neutrophils in 100 micromol/l concentration. Its effect was much less pronounced in the mixture of neutrophils and platelets in the ratio close to physiological conditions (1:50). Our results suggest that stobadine might exert a beneficial effect in diseases or states where superfluous ROS generation could be deleterious.
Management of Atrial Fibrillation in Europe: Current Care Pathways and the Clinical Impact of Antiarrhythmic Drugs and Catheter Ablation
Authors: Velleca Maria , Costa Graca , Goldstein Laura , Bishara Moe , Ming Boo Lee , Sha Qun
Published: October 2022

Atrial fibrillation (AF), the most common form of arrhythmia, increases the risk of heart failure, stroke, and death. Management of AF focusses on effectively and safely controlling irregular heart rhythm, improving symptoms, and reducing complications. Early treatment of AF is important as it may improve patient life expectancy and quality of life (QoL). Current European guidelines recommend an integrated approach to AF management that involves shared decision making between patients and multidisciplinary teams of healthcare professionals to improve access to care and patient compliance. Treatment options include the use of anticoagulants, cardioversion, rate control therapies, and rhythm control therapies. Over the long term, rhythm control strategies that include antiarrhythmic drugs (AAD) and catheter ablation are the most common methods for controlling AF. The objective of this review is to highlight current European AF care pathway management recommendations and to examine the clinical, economic, and patient impact of different treatment options, including AAD and catheter ablation. While AAD have been shown to improve QoL and are affordable in the short term, treatment is moderately effective, associated with significant side effects, and can be costly long term. Catheter ablation is a highly effective therapy choice that improves patient wellbeing and is associated with a low rate of ablation-related complications. Compared to drug therapy, catheter ablation provides a significant reduction in AF burden, reduces rates of recurrence, provides a greater improvement in QoL, and facilitates long-term cost savings.
İsviçre ve Türk Hukuku'ndaki Taşınmaz Rehni Türleri ile Karşılaştırmalı Olarak Avrupa İpoteği (Eurohypotec) Kavramına Genel Bir Bakış
Authors: ATAR Eray Aksın , ESEN Emre
Published: October 2022

Türk Hukuku’nda taşınmaz rehni türleri arasında en yoğun uygulaması olan ipotek hakkı, bağlı bir teminat türü olarak hem borçlu kişi tarafından hem de üçüncü kişi tarafından tesis edilebilen ancak malik lehine kurulması mümkün olmayan tapu siciline tescil ile varlık kazanan bir real teminattır. İpotek hakkı güvence görevini yerine getirirken tedavül imkanı sağlamamaktadır. Uygulaması her ne kadar az olsa da Türk Hukuku’nda yer alan diğer taşınmaz rehni türleri ise ipotekli borç senedi ve irat senedidir. İsviçre Hukuku’nda taşınmaz rehni türleri arasında ipotekli borç senedi ve ipotek bulunmaktadır. İrat senedine ilişkin hükümler ise revizyon sonrasında yürürlükten kaldırılmıştır. İsviçre Hukuku’nda uygulamada sıklıkla tercih edilen ipotekli borç senedi, senede dayalı veya tescile dayalı şekilde çıkarılabilmektedir. İpotekli borç senedi, güvence görevinin yanı sıra tedavül imkanını da sahiptir. Avrupa ipoteği ise Avrupa ülkelerinde ortak bir taşınmaz rehin hukuku yaratılabilmesi için ortaya çıkmış hukuki bir kurumdur. Avrupa ipoteği, özellikle İsviçre Hukuku’nda yer alan ipotekli borç senedine benzer özellikler göstermektedir.
Sivil Toplum-Devlet İkiliğine Yönelik Eleştirel Duruş ve Bunun Kuramsal Öncülleri
Authors: BAYRAK Emek
Published: October 2022

Sivil toplum, teorik tartışmaların önemli kavramlarından biridir. Sivil toplum ve devlet ikiliği, moderniteyle birlikte karşımıza çıkan bir ikiliktir. Tarihsel süreçte bu ikiliğe, farklı anlamlar yüklenmiştir. Bu ayrımın en belirgin ifadesi, klasik ekonomi politikçilerde görülür. Sivil toplum alanı, ekonomik bir kategori olarak, devletten bağımsız ve egoist bireylerin kendi çıkarlarını maksimize ettiği bir alan olarak görülür. Bu ikiliğe yönelik eleştirel anlatılar, Hegel’de ve Marx’ta görülür. Hegel’in anlatısı eleştirel olmakla birlikte; kısmi bir proje olarak kalır. Hegel, bir yozlaşma alanı olarak gördüğü sivil toplum alanına müdahale edilmesi gerektiğini savunur. Bu alana müdahale edecek aktör, etik yaşam projesinin en yüksek uğrağı olan devlettir. Marx’ın projesiyse; bu ikiliğin köktenci bir şekilde aşılmasını amaçlar. Marx’ta belirleyici olan devlet değil, sivil toplumdur. Devlet, sivil toplumdaki sınıf çatışmalarının bir ürünüdür. Marx bu ikiliği, diyalektik bir ilişki olarak kavrar. Bunlardan birinin ortadan kalkmasıyla, diğer öğe de ortadan kalkacaktır. Bunu gerçekleştirecek aktörse, proletaryadır. Bu ikiliğin aşılmasının anlamı; sınıfsal yapının ortadan kalkması, yabancılaşmanın aşılması ve özgürleşmedir. Ve bütüncül bir kurtuluş projesi olarak bu demokrasiye karşılık gelir. Çalışmada, Hegel’in ve Marx’ın bu ikiliğe yönelik eleştirel görüşlerine ve bu görüşlerin içeriğine yer verilecektir.
A New Diagnostic Approach to Assessing Tissue Changes in Type 2 Diabetes Mellitus in Mice Using “LASMA ST” Device
Authors: Stepanova O. I. , Klesov R. A. , Semenov Kh. Kh. , Pomytkin I. A. , Karkischenko V. N.
Published: October 2022

For the first time, LASMA ST, a device for laser diagnostic, was adapted for preclinical studies on laboratory db/db mouse genetic models of type 2 diabetes. The proposed method for studying of tissue changes during diabetes mellitus consists in a simultaneous control of microcirculation compartments: blood and lymph flow and oxidative coenzymes. The presented approach is characterized by a high informational value, safety and objectivity, as well as by the possibility of dynamic monitoring and obtaining online data on tissue metabolism (reduced nicotinamide adenine dinucleotide - NADH and oxidized flavin adenine dinucleotide - FAD).
Antioxidant Effects of Modified-Release Peptide Extracts in Correcting Light Desynchronosis
Authors: Sharabanov A. V. , Batotsyrenova E. G. , Kashuro V. A. , Gasanov M. T. , Komov Yu. V.
Published: October 2022

This research was aimed at creating novel domestic medical preparations with a modified release of active peptide substances obtained from renewable sources of biological materials. These preparations can be used for the purposes of pharmacological correction of desynchronosis by the action of biologically active substances on the processes of lipid peroxidation and antioxidant protection of cells in order to increase the body's resistance to the negative effects of various stress factors. The conducted studies have confirmed the efficacy of modified-release peptide extracts when correcting the body's oxidative status in various types of desynchronosis.
Influence of Combustor Exit Conditions on Cooling Performance of NGV Endwall with Double Row Cooling Holes
Authors:   1Institute of Turbomachinery, School of Energy & Power Engineering, Xi’an Jiaotong University 2Aeronautics Engineering College, Air Force Engineering University, Wang Zhiduo , Wang Zhihao ,   1Shaanxi Engineering Laboratory of Turbomachinery and Power Equipment, Institute of Turbomachinery, School of Energy & Power Engineering, Xi’an Jiaotong University, Feng* Zhenping ,   1Shaanxi Engineering Laboratory of Turbomachinery and Power Equipment, Institute of Turbomachinery, School of Energy & Power Engineering, Xi’an Jiaotong University
Published: October 2022

Modern gas turbine combustor outflow causes non-uniformities to the high pressure turbine, including hot streak and swirl, which will directly influence the flow structure and cooling performance of the nozzle guide vane (NGV) endwall. In this paper, the cooling performance of double row cooling holes at the leading edge area of the endwall is numerically investigated with consideration of a combustor simulator exit conditions. The effect of coolant mass flow ratio (0, 0.5%, 1.0%, 1.5%, 2.0%, 3.0% and 5.0%) of the double row holes on the heat transfer and cooling effectiveness is studied. Furthermore, circumferential positions of the swirl center to the NGV leading edge are compared, including passage-oriented and leading-edge-oriented clockings. It is found that the difference of heat transfer and cooling characteristics under different clocking positions is less obvious on the hub. As for shroud, the clocking effects mainly change the lateral redistributions of the cooling performance. The endwall cooling performance is mainly affected by changes of coolant MFR. The cooling effectiveness improves a lot when the coolant momentum increases to be able to drive the coolant pass through the separation line of the pressure side horseshoe vortex.
Boundary layer separation control of low-pressure turbine blades based on oscillating jet
Authors:   Shanghai Jiao Tong University, Zhou Luanliang , Jing Zifeng ,   Shanghai Jiao Tong University, Wen Xin ,   Shanghai Jiao Tong University, Liu Yingzheng ,   Shanghai Jiao Tong University
Published: October 2022

The Reynolds number (Re) of the low-pressure turbine blades is low in the cruising state, and the laminar boundary layer of the suction surface is prone to separate from the action of the reverse pressure gradient. The separated laminar boundary layer may undergo transition and reattachment, and form laminar separation bubbles. Both situations will cause a lot of energy loss. Therefore, it is necessary to control the boundary layer of the low-pressure turbine with low Re Number. As a relatively new type of active flow control technology, the sweeping jet oscillator does not require moving parts and can generate high-frequency unsteady excitation at the outlet. With the capability of generating jets with a wide range of speeds and high frequencies and adapting to harsh environments with strong electromagnetic interference and radiation, it is an effective means of boundary layer control. From the results of experiments, we found that when Re is 10000, turbulence is 1.8% and the momentum coefficient controlled by the oscillating jet is 0.95%, the boundary layer can be reattached.
Aerodynamic design and performance analysis of the ultra-high expansion ratio turbine for trans-media engines
Authors:   College of Power and Energy Engineering, Harbin Engineering University, Wu Siyu , Gao* Jie ,   College of Power and Energy Engineering, Harbin Engineering University, Zhou Cheng ,   College of Power and Energy Engineering, Harbin Engineering University, Fu Weliang ,   College of Power and Energy Engineering, Harbin Engineering University
Published: October 2022

In order to produce more specific workintrans-media engines, which features low-mass flow feeding systems, the flow loss of ultra-high expansion turbine with single stage need to be studied further. In this paper, the numerical method was used to carry out calculations for turbines in both air and underwater working conditions, and the flow fields inside the flow passage of ultra-high expansion ratio turbines are studied in detail. The results show that the power, efficiency and flow requirements of the engine in the air condition and underwater conditions can be met by changing the number of nozzles and the throat area while keeping the blades unchanged. In underwater working conditions, shock waves are formed obviously between one nozzle outlet and suction surfaces of three rotor blades, while in the air conditions, shock waves are only formed between one nozzle outlet and suction surface of two rotor blades . Therefore, overall, the efficiency in the underwater condition is significantly less than that in the air condition. In the both conditions, the gas in the blade passage corresponding to the circumferential gap between the two nozzles generates vortices due to mutual mixing, resulting in vortex losses.
URANS Simulations of Deposition in a Rotor Passage of the First-Stage Turbine for an Aero-Engine
Authors:   Shaanxi Engineering Laboratory of Turbomachinery and Power Equipment, Institute of Turbomachinery, Xi’an Jiaotong University, Hao Zihan , Yang Xing ,   Shaanxi Engineering Laboratory of Turbomachinery and Power Equipment, Institute of Turbomachinery, Xi’an Jiaotong University, Wang Xiangyu ,   Shaanxi Engineering Laboratory of Turbomachinery and Power Equipment, Institute of Turbomachinery, Xi’an Jiaotong University, Feng* Zhenping ,   Shaanxi Engineering Laboratory of Turbomachinery and Power Equipment, Institute of Turbomachinery, Xi’an Jiaotong University
Published: October 2022

Atmospheric particulate pollutants in high-temperature and high-speed gas are prone to deposit in aero-engine turbines. The deposition changes the blade profile, resulting in a degradation of aerodynamic performance, increases surface roughness and blocks film cooling holes and internal cooling channels, thus reducing the cooling performance of the blade. Therefore, the blades are easily ablated, especially for the rotating parts as they have high rotating speed. In present study, unsteady numerical simulations were performed to investigate the effects of particle deposition by studying the movement patterns and deposits distributions of particles in the rotor passages. The effects of rotating speed, tip clearance, and cavity depth on the movement and deposition of contaminant particles were illustrated. Results show that the deposition on the blade surfaces varies with the rotating speeds and the rotor tip clearances. The deposits are mainly concentrated on the pressure side of the blade where multiple rebounds of the particles are observed under a cruise operating condition. More particles flow into the tip clearance carried by the stronger leakage flow resulted from a larger tip clearance, and the squealer tip increases the capture efficiency of the particles on the blade tip.
A TEMPERATURE-GRADIENT CORRECTION METHOD FOR FILM COOLING EFFECTIVENESS MEASUREMENT USING ENDOSCOPE-BASED PSP TECHNIQUE
Authors:   Shanghai Jiao Tong University, Wang Kechen , Peng Di ,   Shanghai Jiao Tong University, Liu Yingzheng ,   Shanghai Jiao Tong University, Zhou Wenwu ,   Shanghai Jiao Tong University
Published: October 2022

The temperature gradient along the turbine vane can lead to significant uncertainty when the Pressure Sensitive Paint (PSP) technique is applied to film cooling measurements in compressible flow conditions. The current study presents a calibration surface based on temperature ratio to correct the temperature-induced errors using single-luminophore PSP. An endoscope-based PSP system and thermocouples were adopted to investigate the cooling performance and temperature over a turbine vane pressure side (PS) surface in a transonic wind tunnel. Carbon dioxide (DR =1.53) as coolant was discharged into the flow passage through seven rows of holes (i.e., three rows of circular holes and five rows of 7-7-7 shaped holes) with the mass flow ratio (MFR) of 0.6%, 0.9%, 1.06% and 1.21%. The errors of PSP results were greatly reduced at different temperature ratios with the assistance of temperature corrections. This method makes it more suitable for film cooling diagnosis using PSP in compressible flow conditions.
RESEARCH ON APPLYING FREE-FORM DEFORMATION IN AIRFOIL PARAMETERIZATION AND AERODYNAMIC OPTIMIZATION
Authors:   Harbin Institute of Technology, Hu Handuo , Song Yanping ,   Harbin Institute of Technology, Yu Jianyang ,   Harbin Institute of Technology, Liu Yao ,   Harbin Institute of Technology, Chen Fu ,   Harbin Institute of Technology
Published: October 2022

The key to an efficient parameterization method in airfoil design optimization is to control aerodynamic shape accurately with as few parameters as possible. Due to the disadvantages of traditional parameterization methods, such as plentiful variables and inflexible deformation, the Free-form Deformation (FFD) technique is getting attention. This work explores the capabilities of FFD applying in airfoil parameterization and design optimization by comparing with classical methods including B–splines and Class–Shape Transformation (CST). Firstly, a transonic airfoil RAE2822 is parameterized by three methods and their fitting errors are examined. Furthermore, numerical simulations are performed and the results are validated by comparison with experimental data. Finally, the surrogate-based optimization using Kriging model and genetic algorithm is carried out separately with each parameterization method. The results show that FFD can achieve flexible and accurate deformation with the least parameters. Moreover, the reduction of design variables accelerates convergence of optimization, thereby improving design efficiency. Among the optimized airfoils, FFD method achieves the greatest improvement on lift coefficient. Therefore, the capability of FFD method applying in aerodynamic design optimization is demonstrated.
NUMERICAL INVESTIGATION OF DIFFERENT TURBULENCE MODELS APPLIED IN COMBINED IMPINGEMENT AND FILM COOLING
Authors:   Tsinghua University, Yao Min , Wei Jieli ,   Tsinghua University, Ren Zhuyin ,   Tsinghua University, Gan Xiaohua ,   Tsinghua University
Published: October 2022

Numerical investigations of combined impingement and film cooling based on different turbulence models have been carried out and compared in the present study. The specific test case combines the complex flow physics of the jet impinging, turning and subsequent mixing with hot mainstream, which consists of jet shear layer separation, wall boundary layer transition, coolant jet detachment and reattachment. The turbulence models employed are the k  − standard, RNG, and realizable models, the k − standard, SST, and Transition SST models, and the t l k − k − model. Numerical tests have been performed at three representative blowing ratios from low to high for each turbulence model. The computed cooling effectiveness from  equation models tend to be underpredicted at low blowing ratio while numerical profiles of cooling effectiveness achieve considerable agreement with the measured experiment data at moderate and high blowing ratios. In addition, the computed results from  equation models reasonably match the measured data at low blowing ratio but cooling effectiveness are markedly underpredicted at moderate and high blowing ratios. In contrast, those results from the t l k − k − model agree fairly well with those of the experiment at various blowing ratios. Owing to the nature description of the pre-transitional streamwise fluctuations in the laminar kinetic energy, the solutions from t l k − k − model clearly reveal the complex flow physics in the combined impinging and film cooling in the confined region, where the jet shear layer separation, boundary layer transition, coolant detachment and reattachment co-exist. However, the large number of specified parameters in the t l k − k − model still needs to be further optimized to reach the enhanced agreement with experimental data and obtain extensive applications for combined cooling schemes.