bluuebunny/crossref_metadata_2025 huggingface dataset:
Network Pharmacology Combined with Animal Models to Investigate the Mechanism of ChangPu YuJin Tang in the Treatment of Tourette Syndrome
Authors: Lu Man-Qi , Shi Zheng-Gang , Shang Jing , Gao Lei , Gao Wei-Jiao , Gao Lu
Published: May 2024

Background:

ChangPu YuJin Tang (CPYJT) is a Chinese herbal formula that has
been shown to be an effective therapeutic strategy for pediatric patients with Tourette Syndrome
(TS). Using an integrated strategy of network pharmacology and animal model, the aim
of this study was to investigate the mechanism of CPYJT in the treatment of TS.

Methods:

Compound libraries of CPYJT were established using databases, such as the Traditional
Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP).
The TCMSP database and Swiss Target Prediction database were used to predict the targets.
The above results were constructed into a CPYJT-Drug-Component-Target network. Moreover,
TS targets were predicted using GeneCards and other databases. The targets corresponding
to the potential ingredients in CPYJT and the targets corresponding to TS were taken as the intersections
to construct the CPYJT-TS network. The target network was analysed by PPI using
the string database. GO and KEGG enrichment analyses were performed on the target network.
The whole process was performed using Cytoscape 3.7.2 to make visual network diagrams of
the results. CPYJT was characterised by Ultra-Performance Liquid Chromatography-Tandem
Mass Spectrometry (UHPLC-MS). Transmission Electron Microscopy (TEM) was used to observe
the structural changes of CPYJT on the neuronal cells of the IDPN model rats. RT-PCR
and Western Blot were used to analyse the changes in the mRNA and protein expression levels
of BDNF, TrkB, PI3K, and AKT in the cortex, striatum, and thalamus brain regions after
CPYJT administration in IDPN model rats.

Results:

Network pharmacology and UHPLC-MS studies revealed that CPYJT acted on the TS
through multiple neurotransmitters and the BDNF/TrkB and PI3K/AKT signalling pathways.
CPYJT ameliorated neurocellular structural damage in the cortex, striatum, and thalamus of TS
model rats. Additionally, CPYJT up-regulated the levels of BDNF, TrkB, PI3k, and AKT in
the cortex, striatum, and thalamus of TS model rats.

Conclusion:

It was found that CPYJT protected neuronal cells from structural damage in multiple
brain regions and affected the expression levels of BDNF, TrkB, PI3K, and Akt in the
cortex, striatum, and thalamus during TS treatment.
ANRIL: A Long Noncoding RNA in Age-related Diseases
Authors: Wang Rui , Yuan Qi , Wen Yuan , Zhang Yifan , Hu Yaqi , Wang Shuwen , Yuan Chengfu
Published: May 2024

:

The intensification of the aging population is often accompanied by an increase in agerelated diseases, which impair the quality of life of the elderly. The characteristic feature of aging is
progressive physiological decline, which is the largest cause of human pathology and death worldwide. However, natural aging interacts in exceptionally complex ways within and between organs,
but its underlying mechanisms are still poorly understood. Long non-coding RNA (lncRNA) is a
type of noncoding RNA that exceeds 200 nucleotides in length and does not possess protein-coding
ability. It plays a crucial role in the occurrence and development of diseases. ANRIL, also known as
CDKN2B-AS1, is an antisense ncRNA located at the INK4 site. It can play a crucial role in agerelated disease progression by regulating single nucleotide polymorphism, histone modifications, or
post-transcriptional modifications (such as RNA stability and microRNA), such as cardiovascular
disease, diabetes, tumor, arthritis, and osteoporosis. Therefore, a deeper understanding of the molecular mechanisms of lncRNA ANRIL in age-related diseases will help provide new diagnostic and
therapeutic targets for clinical practice.
Prenatal Exposure to the 1944-45 Dutch Famine and Risk for Dementia up
to Age 75: An Analysis of Primary Care Data
Authors: Wiegersma Aline Marileen , Boots Amber , van Bussel Emma F. , Lissenberg-Witte Birgit I. , Nielen Mark M.J. , Roseboom Tessa J. , de Rooij Susanne R.
Published: May 2024

Background:

A poor prenatal environment adversely affects brain development.
Studies investigating long-term consequences of prenatal exposure to the 1944-45 Dutch famine
have shown that those exposed to famine in early gestation had poorer selective attention, smaller
brain volumes, poorer brain perfusion, older appearing brains, and increased reporting of cognitive
problems, all indicative of increased dementia risk.

Objective:

In the current population-based study, we investigated whether dementia incidence up
to age 75 was higher among individuals who had been prenatally exposed to famine.

Methods:

We included men (n=6,714) and women (n=7,051) from the Nivel Primary Care
Database who had been born in seven cities affected by the Dutch famine. We used Cox regression
to compare dementia incidence among individuals exposed to famine during late (1,231), mid
(1,083), or early gestation (601) with those unexposed (born before or conceived after the famine).

Results:

We did not observe differences in dementia incidence for those exposed to famine in mid
or early gestation compared to those unexposed. Men and women exposed to famine in late gestation
had significantly lower dementia rates compared to unexposed individuals (HR 0.52 [95%CI
0.30-0.89]). Sex-specific analyses showed a lower dementia rate in women exposed to famine in
late gestation (HR 0.39 [95%CI 0.17-0.86]) but not in men (HR 0.68 [95%CI 0.33-1.41]).

Results:

We did not observe differences in dementia incidence for those exposed to famine in mid
or early gestation compared to those unexposed. Men and women exposed to famine in late gestation
had significantly lower dementia rates compared to unexposed individuals (HR 0.52 (95%CI
0.30-0.89)). Sex-specific analyses showed a lower dementia rate in women exposed to famine in
late gestation (HR 0.39 (95%CI 0.17-0.86)) but not in men (HR 0.68 (95%CI 0.33-1.41)).

Conclusion:

Although prenatal exposure to the Dutch famine has previously been associated with
measures of accelerated brain aging, the present population-based study did not show increased dementia
incidence up to age 75 in those exposed to famine during gestation.
Therapeutic Interventions for Diabetes Mellitus-associated Complications
Authors: Pradhan Dharmendra , Sahu Prafulla Kumar , Purohit Sukumar , Ranajit Santosh Kumar , Acharya Biswajeet , Sangam Shreya , Shrivastava Amit Kumar
Published: May 2024

Background:

Diabetes Mellitus (DM) is an alarming health concern, affecting approximately
537 million people worldwide. As a leading cause of morbidity and mortality, DM demands
a comprehensive understanding of its diverse pathophysiological mechanisms and disease
progression.

Methods:

This traditional review has consolidated literature on the pathogenesis of hyperglycemia,
its progression into complications, and advances in optimal treatment strategies. The literature
in the last two decades has been reviewed using several keywords, including “diabetes,”
“diabetes-associated complications”, “novel therapeutic interventions for diabetes-associated
diseases”, “phyto-extracts as antidiabetic drugs”, etc. in prominent databases, such as PubMed,
Scopus, Google Scholar, Web of Science, and ClinicalTrials.gov.

Results:

We have discussed macrovascular and microvascular complications, such as atherosclerosis,
cardiovascular disease, Peripheral Arterial Disease (PAD), stroke, diabetic nephropathy,
retinopathy, and neuropathy, as well as various pharmacological and non-pharmacological interventions
that are currently available for the management of DM. We have also focused on the
potential of natural products in targeting molecular mechanisms involved in carbohydrate metabolism,
insulin production, repair of pancreatic cells, and reduction of oxidative stress, thereby
contributing to their antidiabetic activity. Additionally, novel therapeutic approaches, like genetic,
stem cell, and immunomodulatory therapies, have been explored. We have also discussed
the benefits and limitations of each intervention, emerging research and technologies, and precision
medicine interventions.

Conclusion:

This review has emphasized the need for an improved understanding of these advancements,
which is essential to enhance clinicians' ability to identify the most effective
therapeutic interventions.
Optimization Design of the Luffing Mechanism of Truck Crane Based on NSGA-II
Authors: Xin Yunsheng , Lv Shuyi , Dong Ruiyi
Published: May 2024

Background:

The luffing mechanism of the truck crane is one of the key components of
the crane, which is used to control the extension and contraction of the telescopic boom to achieve
the luffing function of the crane. With the development of the engineering environment, the lifting
height of the truck crane is getting higher and higher, the lifting mass is getting bigger and bigger,
and the force situation of the crane luffing mechanism is becoming more and more complicated, in
order to improve the stability of the lifting process, it is necessary to carry out the optimization
work of the luffing mechanism.

Objective:

The purpose of this study is to optimize the luffing mechanism of the truck crane, improve
the lifting performance, and improve the stability of the lifting process.

Methods:

Inspired by the patent, this paper takes the position of the three hinge points of the luffing
mechanism of the truck crane as a research object, carrying on the force analysis, through the
mathematical model. The multi-objective optimization model is established with the maximum
force, maximum total length change rate and maximum stroke of the variable amplitude hydraulic
cylinder as the optimization objectives. The multi-objective genetic algorithm was selected to
compute the optimization model. Finally, the satisfaction function based on the robust design
method and analytic hierarchy process is established, the optimization results are sorted and
screened, and the optimal solution of the three optimization objectives is obtained.

Results:

The mathematical model of the structural force was established through mathematical derivation,
and the optimization model was solved using MATLAB combined with multi-objective
genetic algorithm, and the optimization results show that the force, total length change rate and
range of amplitude of the luffing mechanism have been improved.

Conclusion:

The mathematical model, the multi-objective optimization method and the satisfaction
function method are effective for the optimization of the luffing mechanism. It can be extended and
applied to other construction machinery with boom luffing mechanisms and provide a reference for
patent application.
Current State of Metals and Metal Matrix Composite Forming Modeling
in Semisolid State
Authors: Javdani Akbar , Golbaghi Kian , Najafabadi Mehdi Ahmadi , Pouyafar Vahid
Published: May 2024

Semisolid processing is a production method for metallic alloys and metal matrix composites
by subjecting them to temperatures between the solidus and liquidus. The material then behaves
thixotropically as it flows when sheared but thickens again when allowed to stand. Die design
and process prerequisites such as ram speed, time, and needed lubricants were all part of the trialand-
error process. In general, rules controlling the designation of the casting and forging molds
cannot be directly applied to metallic alloys and metal matrix composites (MMCs) in a semisolid
state since the flow behavior of the materials in a semisolid state is different from that of a completely
liquid or thoroughly solid form; therefore, a better and more comprehensive understanding
of the semisolid flow behavior within the mold, the dominant frictional conditions, and optimized
attributes of the process can be valuable steps in industrialization. The efforts put into industrializing
and introducing patents on semisolid processes throughout recent years reveal the need to analyze
the possibility of forming intricate industrial parts. This short review article reviews trends of
numerical works on the semisolid forming of metals and metal matrix composites.
Drug Target to Alleviate Mitochondrial Dysfunctions in Alzheimer’s
Disease: Recent Advances and Therapeutic Implications
Authors: Rahman Md. Ataur , Rahman MD. Hasanur , Rhim Hyewhon , Kim Bonglee
Published: May 2024

:

Alzheimer's disease (AD) is a severe progressive neurodegenerative condition associated
with neuronal damage and reduced cognitive function that primarily affects the aged worldwide.
While there is increasing evidence suggesting that mitochondrial dysfunction is one of the most significant
factors contributing to AD, its accurate pathobiology remains unclear. Mitochondrial bioenergetics
and homeostasis are impaired and defected during AD pathogenesis. However, the potential of mutations
in nuclear or mitochondrial DNA encoding mitochondrial constituents to cause mitochondrial
dysfunction has been considered since it is one of the intracellular processes commonly compromised
in early AD stages. Additionally, electron transport chain dysfunction and mitochondrial pathological
protein interactions are related to mitochondrial dysfunction in AD. Many mitochondrial parameters
decline during aging, causing an imbalance in reactive oxygen species (ROS) production, leading to
oxidative stress in age-related AD. Moreover, neuroinflammation is another potential causative factor
in AD-associated mitochondrial dysfunction. While several treatments targeting mitochondrial dysfunction
have undergone preclinical studies, few have been successful in clinical trials. Therefore, this
review discusses the molecular mechanisms and different therapeutic approaches for correcting mitochondrial
dysfunction in AD, which have the potential to advance the future development of novel
drug-based AD interventions.
Categorización del riesgo de extinción y primer registro para Colombia de Cycnoches suarezii (Orchidaceae, Catasetinae)
Authors: Lizcano Alejandro , Sánchez-Cortez Danny , Trujillo Trujillo Edwin , Perdomo Oscar
Published: May 2024

Antecedentes y Objetivos: La subtribu Catasetinae (Orchidaceae) está compuesta por 354 especies pertenecientes a ocho géneros, Catasetum, Clowesia, Cyanaeorchis, Cycnoches, Dressleria, Galeandra, Grobya y Mormodes, distribuidos en el Neotrópico. El género Cycnoches abarca 34 especies, 11 de las cuales están registradas para Colombia. En el presente artículo reportamos a C. suarezii por primera vez para este país, establecemos su categoría de riesgo de extinción siguiendo los lineamientos de la UICN, y planteamos estrategias para su protección y conservación.
Métodos: Las poblaciones que reportamos se encontraron durante expediciones botánicas en el piedemonte Andino-Amazónico, en los municipios El Doncello y Florencia, ambos en el departamento Caquetá. La categorización del riesgo de extinción se basó en el criterio B de la UICN, que considera datos de distribución, número de registros y estado de conservación del hábitat. Finalmente, realizamos una revisión de experiencias de conservación desarrolladas con otras orquídeas para proponer estrategias para la protección de C. suarezii y su hábitat.
Resultados clave: Presentamos el primer registro de C. suarezii para Colombia mediante dos poblaciones halladas en los municipios Florencia y El Doncello, departamento Caquetá. Con este registro, la riqueza del género en Colombia se incrementa a 12 especies. Proponemos la categoría En Peligro (EN) a nivel global debido al bajo número de poblaciones, el deterioro de su hábitat por causa de la deforestación, la cual supera 20% de la Extensión de Presencia (EOO) en las últimas dos décadas.
Conclusiones: Cycnoches suarezii se suma a la orquideoflora de Colombia y el piedemonte Andino-Amazónico del departamento de Caquetá. Proponemos estrategias in situ, ex situ y circa situm para su conservación y la de su hábitat.
Evaluating the Effects of a Self-Help Mobile Phone App on Worry and Rumination Experienced by Young Adults: Randomized Controlled Trial
Authors: Edge Daniel , Watkins Edward , Newbold Alexandra , Ehring Thomas , Frost Mads , Rosenkranz Tabea
Published: May 2024

Background

Delivery of preventative interventions via mobile phone apps offers an effective and accessible way to address the global priority of improving the mental health of adolescents and young adults. A proven risk factor for anxiety and depression is elevated worry and rumination, also known as repetitive negative thinking (RNT).

Objective

This was a prevention mechanism trial that aimed to investigate whether an RNT-targeting self-help mobile phone app (MyMoodCoach) reduces worry and rumination in young adults residing in the United Kingdom. A secondary objective was to test whether the app reduces symptoms of anxiety and depression and improves well-being.

Methods

A web-based, single-blind, 2-arm parallel-group randomized controlled trial was conducted with 236 people aged between 16 and 24 years, who self-reported high levels of worry or rumination. Eligible participants were randomized to an active intervention group (usual practice, plus up to 6 weeks of using the RNT-targeting mobile app, n=119) or a waitlist control group (usual practice with no access to the app until after 6 weeks, n=117). The primary outcome was changes in worry and rumination 6 weeks after randomization. Secondary outcomes included changes in well-being and symptoms of anxiety and depression after 6 weeks and changes in all measures after 12 weeks.

Results

Participants randomly allocated to use the RNT-targeting self-help app showed significantly lower levels of rumination (mean difference –2.92, 95% CI –5.57 to –0.28; P=.03; ηp2=0.02) and worry (mean difference –3.97, 95% CI –6.21 to –1.73; P<.001; ηp2=0.06) at 6-week follow-up, relative to the waitlist control. Similar differences were observed for well-being (P<.001), anxiety (P=.03), and depression (P=.04). The waitlist control group also showed improvement when given access to the app after 6 weeks. Improvements observed in the intervention group after 6 weeks of using the app were maintained at the 12-week follow-up point.

Conclusions

The MyMoodCoach app had a significant positive effect on worry and rumination, well-being, anxiety, and depression in young adults, relative to waitlist controls, providing proof-of-principle that an unguided self-help app can effectively reduce RNT. This app, therefore, has potential for the prevention of anxiety and depression although longer-term effects on incidence need to be directly evaluated.

Trial Registration

ClinicalTrials.gov NCT04950257; https://www.clinicaltrials.gov/ct2/show/NCT04950257

International Registered Report Identifier (IRRID)

RR2-10.1186/s12888-021-03536-0
The tools of cognitive creativity assessment
Authors: Khramtsov D.M. , Muratova T.M. , Vikarenko M.S. , Vorokhta Yu.M.
Published: May 2024

Background. The purpose of the study was to assess the occurrence of disorders in the field of cognitive creativity in patients with minimal manifestations of leukoencephalopathy. Materials and methods. The study was carried out in the Expert Health Center in 2021–2022. We have examined 43 patients aged 45–60 years who had hyperintense foci in the white matter of the brain on magnetic resonance imaging, meeting Fazekas 1 criteria, and preserved cognitive abilities according to the MMSE and MoCA (≥ 25 and ≥ 26 points, respectively). As a control, 20 people of the same age with Fazekas 0 were examined, including 9 people employed in the creative professions. Additionally, all participants were examined using the Divergent Association Task (DAT). Statistical processing of the obtained results was performed by methods of dispersion and correlation analysis using Statistica 14.1 software (TIBCO, USA). Results. The average age of patients in the main group was 53.1 ± 0.3 years, while in the controls, it was 52.6 ± 0.5 years. In patients with signs of minimal microangiopathy of cerebral vessels, the MMSE score was on average 26.4 ± 0.2 points, and MoCA — 27.0 ± 0.3 points, while in the control group, 27.8 ± 0.2 and 28.1 ± 0.3 points, respectively (p < 0.05). In the main group, the DAT was on average 59.0 ± 1.3 %, while in the controls, it was 81.9 ± 1.1 % (Z = 3.8; p = 0.0001). The highest indicators of DAT were found in workers of creative specialties — 85.0 ± 0.9 % (Z = 2.7; p = 0.008). Conclusions. There was demonstrated that 95.0 % of patients with minimal manifestations of leukoencephalopathy caused by microangiopathy had a decrease in creative abilities (DAT 59.0 ± 1.3 vs. 81.9 ± 1.1 %; Z = 3.8; p = 0.0001). The coefficient of internal agreement of the DAT test αk was 0.7 with a reproducibility of 85.7 %, which allows recommending the method for use in clinical practice. The method of assessing associative tasks on divergent thinking has a higher sensitivity (97.7 %) than traditional methods of evaluating cognitive abilities at subclinical stages of chronic cerebral blood flow disorders.
Studi Komparasi Teknik Klasifikasi berbasis Objek terhadap Citra Resolusi Spasial Menengah dan Tinggi untuk Pemetaan Tutupan Lahan di Sebagian Kabupaten Kulonprogo
Authors: Putri Erisa Ayu Waspadi , Danoedoro Projo , Farda Nur Mohammad
Published: May 2024

Abstrak Tingginya kebutuhan informasi tutupan lahan dalam berbagai sektor perencanaan dapat disediakan secara time-and-cost effective melalui analisa citra penginderaan jauh, diantaranya menggunakan OBIA (object based image analysis). Teknik tersebut banyak diterapkan pada berbagai macam citra, baik resolusi spasial tinggi maupun menengah. Namun studi komparasi pada citra resolusi spasial yang berbeda masih belum banyak dilakukan secara comparable, dimana umumnya terdapat banyak perbedaan variable komparasinya. Penelitian ini bertujuan untuk membandingkan secara langsung penerapan OBIA terhadap resolusi spasial citra yang berbeda dengan membatasi variable berpengaruh terhadap akurasi, diantaranya: klasifikasi jenis tutupan lahan, saluran masukan citra, dan kriteria serta teknik klasifikasi OBIA. Berdasarkan studi komparasi, diketahui bahwa penggunaan Pleaides memberikan akurasi yang lebih tinggi dibanding Landsat-8 OLI namun memerlukan strategi klasifikasi yang lebih rumit. Sedangkan ditinjau dari overall accuracy dan indeks kappa, disimpulkan bahwa OBIA mampu memberikan akurasi hasil yang termasuk dalam acceptable thresholds untuk derivasi tutupan lahan menggunakan citra resolusi spasial tinggi ataupun menengah.Abstract The high demand for land cover information for vast planning sectors could be provided in time-and-cost-effective techniques using remote sensing image analysis, including employing OBIA (object based image analysis). The technique is widely applied to various kinds of imageries, for high and medium spatial resolution as well. However, comparative studies on the usage of different spatial resolution imageries have not been carried out in a comparable condition, where several variables could be in different terms. The study aims is to straightly compare OBIA’s application in diverse spatial resolution of imagery by limiting the affecting variables to its accuracy, including classification of land cover schemes, imagery channels input, and OBIA’s criteria and techniques. The comparative study reveals the usage of Pleaides provides higher accuracy than Landsat-8 OLI but requires a more complicated classification strategy. Meanwhile, the overall accuracy and kappa index of both maps exposes that OBIA could provide scientifically acceptable accurate land cover maps derived from both high and medium spatial resolution imagery.
Memory Writing and Identity Construction in Abdulrazak Gurnah’s Admiring Silence
Authors: Qingyue Zheng
Published: May 2024

Abdulrazak Gurnah is an Afro-British diaspora writer who won the Nobel Prize for Literature in 2021. His works, which center on issues like identity, racial tensions, and historical writing, mostly depict the living conditions of colonial peoples, refugees, and immigrants. Admiring Silence is a novel written by Gurnah in 1996. It tells the story of a Zanzibar refugee who, after 20 years of diaspora in Britain, is able to return home, but then has to choose to return to Britain immediately. This article takes spatial migration and diaspora under post-colonialism as the background for studying refugees and applies cultural memory theory and identity theory to analyze the memory and identity construction issues in Admiring Silence. Finally, it attempts to explain the reasons for the memory and identity dilemma of diaspora groups from the perspectives of colonialism and racism in the suzerain country, as well as the failed acculturation of diaspora refugees themselves.
Predictors of Student Success in College-Level General Chemistry
Authors:   Binghamton University, Engler Elijah J. , Kelleher Clarice AK ,   Binghamton University
Published: May 2024

Success in college-level general chemistry is important because it is a required course for many different STEM majors and student success in early STEM classes correlates with retention of students in STEM. Identifying factors associated with success and failure can give educators a better understanding of the warning signs to look out for in struggling students. This paper compares factors and behaviors with final grades in general chemistry courses at Binghamton University, including adjectives selected from a word bank (“valued,” “supported,” etc.), resources used, and opinion on group work as it relates to learning. Correlations were found between student adjective selection and final grade, resource use and final grade, and perspective on group work and final grade.
“The Scepter Shall Not Depart from Judah”: Jews and Imperial Power in Benjamin of Tudela’s Book of Travels
Authors:   Binghamton University, Elul Azriel
Published: May 2024

This paper, written as a final project for Professor Shay Rabineau's class “Walking the Land,” examines the relationship of medieval Jews to the imperial powers to which they were subject, as expressed in Benjamin of Tudela's Book of Travels. It focuses on the two imperial cores of Rome and Baghdad, and contextualizes the representation of these two cities within the world of imperial power in which the text was produced. As a work of medieval travel literature, I analyze the Book of Travels not as a factual account of history, but rather as a discursive and imaginative text which seeks to categorize and make comprehensible the world inhabited by medieval Jewry. I argue that the representations of imperial power and Jewish status in Rome and Baghdad on their face reflect a desire on the part of medieval Jews for respect, honor, and dignity from the non-Jewish rulers to whom they were subject. However—as can be gleaned from Benjamin of Tudela’s reproachful account of messianic claimant David Alroy—the glowing accounts of these twin imperial cores is also a way of encouraging Jews not to disrupt the delicate balance of power in their world. Ultimately, the Book of Travels portrays a complex matrix of Jewish attitudes towards imperial power, including aspiration, fear, and strategically-suppressed antagonism.
Addressing the need for both affordable and sustainable housing: a policy analysis on avoiding environmental gentrification
Authors:   Binghamton University, Zipman Erin
Published: May 2024

This article focuses on the threat of environmental gentrification in Binghamton and the surrounding municipalities. Given certain risks, including an increasing temporary student renter population, increasing rent prices, high population of renters overall and the need for updates to the housing stock, this area of Broome County is at high risk for environmental gentrification if clean energy upgrades to the housing stock are aggressively pursued. Since clean energy upgrades such as weatherization and clean technology installation will create safer housing and reduce residential greenhouse gas emissions, it is desirable to pursue them. Thus, this article will analyze four policy alternatives on their ability to facilitate the implementation of clean energy upgrades while also mitigating green gentrification. It will find that synthesizing the work of local land trusts and housing organizations with efforts to implement clean energy upgrades will best accomplish this.
Societalización y polarización política: el colapso de la línea 12 del metro de la Ciudad de México
Authors: Arteaga Botello Nelson
Published: May 2024

El artículo analiza cómo el colapso de la línea 12 del metro de la Ciudad de México (L-12) disparó un proceso de societalización en el que se acusó a las élites políticas de ser responsables del accidente, exigiendo que asumieran su responsabilidad. La societalización sucede cuando una disfunción inherente de las instituciones deja de estar bajo el control discursivo y simbólico de las élites políticas y es colonizada por la esfera civil. El proceso de societalización de la tragedia de la L-12, se reconstruyó analizando las columnas políticas de cinco periódicos nacionales; se reconoce estas pueden estar sesgadas en las interpretaciones que ofrecen, ya que parten de marcos de interpretación y referentes morales distintos. Este sesgo es importante porque permite observar cómo las interpretaciones activan el proceso de societalización. La societalización del accidente en la L-12 no generó sanciones a los responsables porque la polarización social en el país impidió crear un estándar común de evaluación civil. Consecuentemente, es necesario explorar el peso de las organizaciones civiles en el proceso de societalización, así como de las élites políticas para frenar dicho proceso.
politólogas, las revistas académicas y sus ‘gatekeepers’
Authors: Welp Yanina , Goldfrank Benjamin
Published: May 2024

Los estudios recientes dedicados a la ciencia política latinoamericana han tenido por principal objeto de investigación la institucionalización de la disciplina. Se ha avanzado mucho en el conocimiento de este tema, pero sin apenas incluir la perspectiva de género. Para incluirla, este artículo (1) estima la presencia de profesoras de ciencia política en 107 departamentos de 16 países de la región y (2) en los equipos y (3) consejos editoriales de 85 revistas de ciencia política o latinoamericanistas para luego (4) evaluar una encuesta de editores en 48 de estas revistas. Encontramos que hay una brecha de género significativa tanto en los departamentos como en las revistas (especialmente en los consejos editoriales), que no correlaciona con la institucionalización de la ciencia política. Además, la presencia levemente mayor en los equipos editoriales representa un arma de doble filo. La llegada de mujeres a estos equipos es una oportunidad para su reconocimiento profesional y para influenciar la disciplina, pero requiere trabajar más sin recompensa significativa, mientras que en el puesto más simbólico y menos demandante– el consejo editorial –hay menos mujeres.
Género, instituciones y poder: nuevas tendencias teóricas para el estudio del poder generizado en América Latina
Authors: Gilas Karolina
Published: May 2024

Este artículo examina las nuevas tendencias teóricas en el estudio del género, las instituciones y el poder en América Latina, destacando la importancia de integrar la teoría política feminista y el neoinstitucionalismo feminista en el análisis de las dinámicas políticas de la región. A través de una revisión de la literatura y estudios de caso, el trabajo evidencia cómo estas perspectivas desafían los paradigmas tradicionales y ofrecen una comprensión más profunda de la interacción entre las normas de género, las instituciones políticas y las relaciones de poder. Los hallazgos subrayan la naturaleza generizada de las instituciones políticas y las barreras que enfrentan las mujeres para la participación y representación política. El artículo destaca las contribuciones teóricas y metodológicas de estos enfoques, así como sus implicaciones para la formulación de políticas públicas. Si bien la integración de la perspectiva de género en la ciencia política latinoamericana enfrenta desafíos, también presenta oportunidades significativas para promover la igualdad de género y una gobernanza más inclusiva en la región.
Analysis of healthcare waste generated by drugstores in Belo Horizonte, Brazil
Authors: Rodrigues de Sousa Ana Teresa , Maia Camila Costa , De Castro e Silva Maria Esther , Affonso Kryscia Palhares Napoli , Pataca Luiz Carlos Moutinho , Gonçalves Max Filipe Silva , Vidal Gisele Vimeiro , Mol Marcos Paulo Gomes
Published: May 2024

Healthcare wastes (HCW) are generated in establishments involved in human and animal healthcare activities, including pharmacies and drugstores. These activities also generate HCW, although they have been little studied in the scientific context. The present study aims to quantify and characterize the HCW generated by drugstores in Belo Horizonte, Brazil. Information contained in the Healthcare Waste Management Plans (HCWMP) was used and statistical analyzes were conducted in order to obtain the average generation by waste groups and by regions of the city. From the available data, an average global daily generation of 1218 kg/day (8140 L/day) of HCW was obtained in Belo Horizonte city, with an estimated generation per establishment of 8.98±1.50 kg/day (60±10 L/day), ranging from 0,03 kg/day (0.21 L/day) to 39,64 kg/day (265 L/day). The study revealed that the majority of the waste is non-hazardous, accounting for 97% of the total generated (1185 kg/day; 7900 L/day), while hazardous waste constituted only 3%. Most of the hazardous waste was chemical in nature.
Combating Evolving Threats: A Signature-Anomaly Based Hybrid Intrusion Detection System for Smart Homes with False Positive Mitigation
Authors: Mehedy Hasan MD
Published: May 2024

Abstract: As people are looking for a more comfortable life, IoT applications are coming to play. Smart home system is one of the most popular IoT applications in the last decade. A smart home network is crucial to function smart home system properly. Cyber attacks on a smart home network can damage a lot. Network intrusion detection and prevention system (NIDPS) is a good solution to protect against Cyber threat in smart home network. This research will implement hybrid NIDPS in smart home network by combining signature based and anomaly-detection based NIDPS. This hybrid NIDPS will prevent known known attack from public internet, local internet and zero-day attack. Also, this system will be able to reduce false positive result and improve signature based NIDPS rules accurately by manual inspection.
Monitoring of Water Quality using Machine Learning - A Review
Authors: Y Shashank , Amith Syed , S Sahana , Sastry Dr. Anitha S
Published: May 2024

Abstract: The incorporation of machine learning (ML) can improve the monitoring of water quality. It improves the sustainability and security of water resources by enabling forecasting and early detection of possible water contamination. A real-time system that collects information on numerous water parameters, including pH level, dissolved oxygen, turbidity, temperature, and conductivity, is made possible by the combination of IoT technology with ML algorithms. The system models complex links between water quality parameters and looks for variations from typical patterns using a mix of supervised and unsupervised learning and anomaly detection methods. Advantage of this method include cost-effectiveness, scalability, remote accessible, and real-time monitoring
Pengaruh Paparan Iklan dan Kelompok Referensi Terhadap Minat Beli
Authors: Pamungkas Adie , Maria Hana Diana , Sudianto S. , Kusumah Firdan Gusmara , Maulida Elvira Natasya
Published: May 2024

Advertising is still a powerful promotional medium today, where most aspects of the economy have shifted to online. In this digital era, conventional advertising, which is television advertising, is still an option and is still effective in business to use in promoting their products or brand campaigns. Apart from that, suggestions or recommendations from people around you can have an influence on someone when they make a decision to buy or consume a product. These two factors are combined and researched to find out their influence on purchasing interest from potential consumers. The population of this research is residents of the city of Tasikmalaya and the sampling method is judgment to select respondents to be studied. The results of this study indicate that advertising exposure and reference groups simultaneously and partially influences purchase intention.
APRENDIZAGEM SIGNIFICATIVA E EDUCAÇÃO AMBIENTAL: DISCUTINDO E (RE)SIGNIFICANDO O GERENCIAMENTO DE RESÍDUOS SÓLIDOS URBANOS
Authors: Santos Francisco Rauzito Neris dos , Barros José Deomar de Souza
Published: May 2024

A capacidade de transformação dos ambientes naturais realizada pelos seres humanos foi acentuada, principalmente, a partir do século XVIII marcado pela ascensão da Revolução Industrial, evidenciando os caminhos de degradação que a humanidade estava percorrendo. Por isso, a educação possui um papel crucial em contribuir para a formação de cidadãos críticos-reflexivos que possam atuar na transformação social. Assim, a presente pesquisa objetivou aplicar estratégias potencialmente significativas para a promoção da Educação Ambiental envolvendo o ensino de Ciências.  Para tanto, foram realizadas intervenções pedagógicas respaldadas nos preceitos de Aprendizagem Significativa de David Paul Ausubel em uma escola municipal de Cajazeiras – PB. Os sujeitos consistiram nos alunos do 8º ano do Ensino Fundamental II. Para a análise dos resultados, foi utilizada a técnica de Análise Categorial proposta por Bardin (2016). Os resultados obtidos indicam a incipiência acerca do conhecimento das temáticas ambientais dos estudantes, contudo, as atividades de Educação Ambiental forneceram resultados exitosos e apontam a potencialidade da utilização dos preceitos da Teoria de Aprendizagem Significativa em sala de aula.
Impacto do uso de prebióticos e probióticos como medida terapêutica para a recuperação da microbiota em crianças com transtorno do espectro autista - revisão integrativa
Authors: Ribeiro Edlainny Araujo , Quincór Renata Rodrigues da Silva , Maciel Fernando Antonio Figueiredo
Published: May 2024

O presente artigo apresenta como objetivo analisar o papel clínico do uso de prebióticos e probióticos no manejo de distúrbios gastrointestinais em pacientes com transtorno do espectro autista, bem como descrever as evidências acerca dos benefícios associados. Esta pesquisa consiste em uma revisão integrativa da literatura realizada por meio das bases de dados National Library of Medicine National Institutes of Health (PUBMED e Biblioteca Virtual em Saúde (BVS), publicadas no período de 2012 a 2022. Foram identificados 954 artigos inicialmente e 12 foram incluídos para a revisão. Os probióticos mais frequentes foram Lactobacillus e o Bifidobacteria longum, responsáveis por gerar melhora global dos sintomas gastrointestinais de constipação, dor abdominal e diarreia, e melhora do comportamento social do TEA. Esses probióticos agem a partir da produção de neurotransmissores incluindo dopamina, norepinefrina, serotonina, ácido 4-aminobutírico (GABA), acetilcolina e histamina, que podem modular os níveis de serotonina e dopamina no cérebro, regulando os sintomas de irritabilidade, estereotipia e hiperatividade associada ao TEA. Portanto, faz-se necessária a realização de ensaios clínicos de longa duração a fim de avaliar o impacto do uso de probióticos e prebióticos para as sintomatologias geradas pelo TEA, podendo contribuir para melhora da qualidade de vida desses pacientes.
Stereoselective Synthesis of 2-Deoxy-α-N-Glycosides from Glycals with 1,4,2-Dioxazol-5-ones
Authors: Shen Zhenpeng , Yin Guoyin , Li Yangyang
Published: May 2024

The synthesis of N-glycosides has received significant attention due to
their crucial role in carbohydrate chemistry. Despite considerable
advancements were developed in the construction of N-glycosides, methods
for the stereoselective construction of 2-deoxy-α-N-glycosides are still
limited. Herein, we disclosed a nickel-catalyzed hydroamination of
glycals under mild conditions. This transformation could allow for the
stereoselective synthesis of an array of 2-deoxy-α-N-glycosides with
excellent α-stereoselectivity. Nickel-catalyzed glycosylation reactions,
particularly those involving anomeric C(sp3)-metal bond formation, have
proven to be an effec-tive and stereoselective strategy for producing
various N-glycosides. Additionally, with highlight the application of
this reaction, γ-sugar amino acid derivatives were synthesized by one
step.
Clinical and Laboratory Differences between Steroid-associated and Non-steroid-associated Rosacea: A Retrospective Study
Authors: Kim Tae Min , Cho Soyun
Published: May 2024

Abstract is missing (Short communication)
Risk Factors and Prevention Measures for Specific Shoulder Pain in Laparoscopic Surgery
Authors: Smail Ammari
Published: May 2024

Introduction: Shoulder pain is a specific discomfort associated with laparoscopic procedures. Its pathophysiology remains poorly understood and hypothetical. Several factors have been suggested as potential triggers for this pain. The aim of our study is to assess post-laparoscopic surgery shoulder pain and investigate the risk factors for its occurrence and methods of prevention. Materials and Methods: This is a descriptive and prospective study involving 337 patients who underwent laparoscopic surgery for acute non-traumatic abdominal emergencies between February 2018 and October 2021. Results: Among the 337 operated patients, 190 were females (56.4%), with a mean age of 38 years ± 15 years. Shoulder pain was present in 73 patients (21.6%). Its intensity was low in the majority of cases. The average duration of pain was 1.99 ± 1.09 days. The operative time threshold at which pain began to appear was 34.5 minutes. Pain was less intense in patients who underwent drainage at the end of the procedure (p-value = 0.026 on postoperative day 1). Moreover, there was no correlation between the duration of postoperative shoulder pain and drainage (P= 0.482). Conclusion: The insufflation of CO2 to create pneumoperitoneum and the tensioning of the nerves in the abdominal wall were the factors responsible for shoulder pain in our study. Drainage at the end of the procedure reduced the intensity of the pain but did not prevent its occurrence.
Research on Computer Network Data Security Storage Technology in the Era of Big Data
Authors: Zhang L. , Gu X. , Zhao Q.
Published: May 2024

In the burgeoning epoch of big data, the imperative for secure computer network data storage is confronted with formidable challenges, including the perils of data breaches and a paucity of robust security measures. An enhanced storage paradigm, predicated upon a refined Hash algorithm—termed H-AONT—is herein delineated. This methodology augments data storage security through the formulation of an apposite system model, the amalgamation of the merits inherent in conventional encryption algorithms, and the deployment of the H-AONT dual encryption algorithm in data processing. Empirical evidence substantiates that, vis-à-vis alternative approaches, the proposed method significantly bolsters data storage security, furnishes an elevated stratum of protection for computer network data repositories, ensures data storage reliability, and proffers a pertinent benchmark for the safeguarding of computer network data within the vast landscape of big data.
Pengaruh Uji Kelistrikan Sel Volta Buah Belimbing (Averrhoa carambola) Dengan Luasan Elektroda 6 Cm2 Sebagai Solusi Energi Alternatif Ramah Lingkungan
Authors: Saputro Agung , Fadli Ulfa Mahfudli , Sholichah Nikmatin
Published: May 2024

Pada beberapa jenis buah-buahan seperti buah belimbing memiliki kandungan zat kimia aktif yang dapat diubah menjadi energi listrik. Proses yang dapat dilakukan yakni melalui reaksi reduksi dan oksidasi yang terjadi pada kedua elektroda. Tujuan dari dua konduktor, ketika Cu dan Zn dihubungkan melalui larutan elektrolit dapat membentuk rangkaian menjadi sel volta. Tegangan muncul sebagai akibat reaksi kimia di kedua elektroda. Sedangkan elektroda positif (Cu) mengalami reaksi reduksi, selanjutnya elektroda negatif (Zn) akan mengalami reaksi oksidasi, sehingga elektron mengalir dari seng ke tembaga. Penelitian ini difokuskan pada pengujian buah belimbing (Averrhoa carambola) sebagai larutan elektrolit. Jenis rangkaian seri pararel digunakan sebagai variasi dalam penelitian ini. Sel volta digunakan sebanyak 10 sel untuk menghasilkan tegangan dan arus maksimal. Sel volta buah belimbing dibuat dengan cara merangkai kerangka sel volta dengan kabel dan LED serta diuji dengan voltmeter dan amperemeter. Telah didapatkan pada sel volta belimbing matang dirangkai secara seri menghasilkan tegangan sebesar 4,2 V dan arus 0,2 mA sedangkan jika dirangkai secara pararel menghasilkan tegangan 0,6 V dan arus 1,05 mA. Pada uji ketahanan dengan rangkaian seri, sel volta buah belimbing mampu menyalakan lampu LED hingga 9 hari. Sel volta ini dapat menghasilkan listrik dengan elektroda Cu dan Zn yang tergantung pada kondisi elektrolit
Hubungan Pengetahuan Pencemaran Lingkungan Dengan Perilaku Pro-environmental Berdasarkan Jenjang Kelas
Authors: Afifah Sekar Rana , Hariz Anif Rizqianti , Rofi'ah Ndzani Latifatur
Published: May 2024

AbstrakSumber daya alam dibutuhkan manusia untuk memenuhi kebutuhan hidupnya, sehingga menjadi faktor terjadinya pencemaran lingkungan. Penerapan perilaku pro-environmental merupakan salah satu usaha untuk mengurangi pencemaran lingkungan. Sekolah berkewajiban untuk menumbuhkan kepedulian lingkungan siswa. Jenjang pendidikan yang tinggi akan menambah pengetahuan siswa dan berdampak pada perilaku. Penelitian ini bertujuan untuk menganalisis hubungan antara pengetahuan pencemaran lingkungan dengan perilaku pro-environmental berdasarkan jenjang kelas, menganalisis pengetahuan pencemaran lingkungan berdasarkan jenjang kelas, serta menganalisis perilaku pro-environmental berdasarkan jenjang kelas. Metode yang digunakan yaitu kuantitatif dengan jenis penelitian korelasional. Populasi penelitian menggunakan siswa kelas X dan kelas XI MIPA. Penentuan jumlah sampel dihitung menggunakan rumus slovin dan banyak sampel tiap kelas ditentukan menggunakan proportionate stratified random sampling. Hasil penelitian menunjukkan bahwa tidak ada hubungan antara pengetahuan pencemaran lingkungan dengan perilaku pro-environmental berdasarkan jenjang kelas, hal ini dibuktikan dengan nilai signifikansi sebesar 0,991 pada kelas X dan 0,777 pada kelas XI MIPA, tidak ada beda pengetahuan pencemaran lingkungan berdasarkan jenjang kelas, hal ini dibuktikan dengan nilai signifikansi sebesar 0,051, dan terdapat beda perilaku pro-environmental berdasarkan jenjang kelas, hal ini dibuktikan dengan nilai signifikansi sebesar 0,01.
Analisis Validitas Dan Daya Tarik E-Modul Biologi Untuk Melatihkan Kemampuan Berpikir Kritis
Authors: Imam Moh. , Zaini Muhammad , Suyidno Suyidno
Published: May 2024

Kemampuan berpikir kritis merupakan salah satu aspek dari keterampilan abad ke-21 yang perlu dilatih dengan pembiasaan dalam kegiatan pembelajaran menggunakan bahan ajar. E-Modul merupakan salah satu bahan ajar yang dapat melatihkan kemampuan berpikir kritis peserta didik sehingga perlu dilakukan pengembangan e-modul. Penelitian pengembangan bertujuan untuk memperbaiki dan meningkatkan kualitas e-modul sehingga layak digunakan. Tujuan dari penelitian pengembangan ini untuk mendeskripsikan validitas dan daya tarik e-modul biologi. Jenis penelitian merupakan penelitian pengembangan Educational Design Research dengan desain evaluasi formatif model Tessmer sampai tahap uji one to one. Validitas e-modul dilakukan oleh tiga pakar yang ditinjau dari aspek kelayakan isi, penyajian, bahasa, dan kegrafikan. Sedangkan daya tarik e-modul dilakukan oleh tiga peserta didik yang memiliki tingkat kemampuan rendah, sedang, dan tinggi dengan menggunakan angket daya tarik yang terdiri atas sepuluh aspek penilaian. Hasil validitas menunjukkan kategori sangat valid pada keempat aspek dengan nilai keseluruhan rata-rata 95,4 dan hasil daya tarik menunjukkan sangat baik dengan nilai 90,00. Berdasarkan hasil tersebut, e-modul biologi dapat dinyatakan sangat valid dan memiliki nilai daya tarik.