bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics of Nitrogen Distribution and Influencing Factors in A Reservoir of Henan Province
Authors: Lu Yucan
Published: June 2024

In order to reveal the spatial and temporal distribution characteristics of nitrogen and its influencing factors in a reservoir in Henan Province, a study on the changing characteristics of nitrogen in the water body was carried out in the fall of 2019 and the summer and fall of 2020 to identify the main sources of pollution in the water body in the reservoir area. The results showed that the total nitrogen concentration in the water body ranged from 1.65 to 3.53 mg/L, which exceeded the eutrophication threshold of the water body. Among them, the nitrogen component was dominated by nitrate nitrogen, which accounted for 62.63% of the total nitrogen, mainly from runoff pollution and endogenous release. On a seasonal scale, nitrogen concentrations exhibited higher concentrations in the fall than in the summer. At the spatial scale, total nitrogen, nitrate nitrogen and organic nitrogen concentrations showed similar trends, with a gradual decrease from the upstream to the front of the dam, and an increase after the dam, which was related to the dilution of the water body and the effect of the reservoir's water storage on sand retention. Principal component analysis showed that the key factors affecting water quality in the reservoir were pH, water temperature and ammonia. Pearson correlation analysis showed that the spatial and temporal characteristics of reservoir nitrogen were related to environmental factors, material transport transformations and anthropogenic influences.
Effect of Excitation Vibration at Different Frequencies on Pick Cutting
Authors: Luo Chenxu , Zeng Jiawei , Gao Junhao , Qiao Junbei , Leng Junfa
Published: June 2024

The pick vibration model was established and analyzed, and discussed the influence of vibration at different frequencies on the cutting load. Then a discrete element model of the interface coal seam is established in EDEM to analyze the change of cut load at different vibration frequencies. The conclusion shows that it is more suitable to apply high frequency vibration when the coal seam content is high, and it is more suitable to apply low frequency vibration when the rock layer content is more.
Cave Dwelling: the History and Cultural Inheritance in Contemporary Shanxi
Authors: Ding Pengpeng , Pimpiset Pitipong , Yamcharoen Nattapong
Published: June 2024

Shanxi cave dwellings are a unique habitat and cultural treasure of the Chinese nation, embodying the wisdom and life imprints of the people of the Loess Plateau. With ancient origins rooted in cave dwelling civilizations, Shanxi cave dwellings have evolved over millennia, gradually forming distinctive architectural styles and ways of life. These dwellings are not only the homes of Shanxi farmers but also the cradle of rich and diverse folk cultures deeply intertwined with the literary and artistic heritage of Shanxi. At the same time, their layout and structure reflect the social stratification and family concepts of the local society. With the onset of modernization, the impact of urbanization and new residential trends has posed unprecedented challenges to cave dwelling culture. To safeguard this precious intangible cultural heritage, both central and local governments have introduced a series of protection policies and implemented practical actions. More importantly, it is necessary to vigorously promote innovation and inheritance on the basis of protection, integrating cave dwelling elements into modern design, promoting cultural tourism experiences, and developing cultural and creative industries. This will revitalize this ancient and unique human habitat civilization in contemporary society, continuing the cultural confidence and national spirit of the Shanxi people.
Clinical and Epidemiological Profile of Otorhinolaryngology Diseases at a Tertiary Hospital in Morang District: A Descriptive Cross-Sectional Study
Authors: Bhushan Pandit Shiva , Shah Rajeev Kumar , Gyawali Prakriti
Published: June 2024

Introduction: Otorhinolaryngology, dealing with disorders of the ears, nose, throat, and related structures, poses significant health challenges. However, there is a dearth of extensive clinical and epidemiological data on these ailments in the specific geographic area under study. Understanding the characteristics of otorhinolaryngology diseases is crucial for effective healthcare planning and resource allocation.
Objective: This study aimed to determine the clinical and epidemiological profile of otorhinolaryngology diseases at a tertiary hospital in Morang District, Nepal.
Methodology: An observational descriptive cross-sectional study was conducted at the Otorhinolaryngology department of a tertiary hospital in eastern Nepal from January 15 to February 15, 2024. Data from 600 patients presenting at the department over one month were meticulously analyzed.
Results: The median age of patients was 28 years, with the most prevalent age group being 21- 30 years (23%). A majority (56%) were male, and belonged to the Brahmin/Chhetri caste (44.3%). Most patients (85%) initially visited the hospital through OPD, with ear-related issues (35.2%) being the most common complaint. Epistaxis (10.3%) was the most frequent diagnosis, followed by allergic rhinitis (9%) and ear wax issues (8.2%). The prevalence of carcinoma was 12(2%). The majority (77.3%) underwent medical treatment. Outpatient admissions were observed in 68(13.3%) of cases, with emergency admissions accounting for 42(62.6%).
Conclusion: Epistaxis, allergic rhinitis, and ear wax problems were commonly encountered. Most patients underwent medical treatment, with only a minority requiring hospital admission, primarily through outpatient services.
Increasing the prevention of process failure and the overall resilience of businesses through the process risk assessment
Authors: Kardos Peter , Chmielova Dalajkova Iveta , Ahmad Najid
Published: June 2024

Research background: Properly set processes represent the basic framework of enterprise management. By assessing process risks, enterprises can timely identify problems in the implementation of processes, which can cause failure or interruption of activity, a decrease in performance, an increase in process costs, etc. Purpose of the article: The aim of the article is to identify, analyse and quantify the approach of enterprises to process risk assessment with the intention of improving processes, increasing the prevention of process failures and the overall resilience of the organization. Methods: A questionnaire was created to find out the attitudes of enterprises in the assessment of process risks. Data collection was carried out by an external agency using the Computer Assisted Web Interview method. The sample consisted of 353 enterprises from the business environment of the Slovak Republic. The questionnaire was evaluated using the simple sorting method. The research hypotheses were evaluated by applying Chi-square test. Findings & Value added: Enterprises most often assess risks in quality control, production processes, service provision processes. The frequency of assessment of process risks is for a third of the enterprises with every change, planning, disagreement or fluctuation of the economic indicator. More than 40% of Slovak enterprises do not have any management system implemented. The business sector is an important factor in the use of methods for the identification, analysis and evaluation of process risks. To identify process risks, in service sector, the owner/manager's own experience is used to a greater extent than in enterprises in industry. Enterprises in service sector use risk detection for risk analysis, industrial enterprises use process FMEA. Enterprises in service sector use scenarios analysis and enterprises in industry use the effectiveness of measures to evaluate process risks. Every tenth enterprise stated that the human factor is the cause of the occurrence of problems in up to 70% of all processes in the enterprise. Enterprises in service sector for process measurement use productivity of the enterprise to a greater extent than enterprises in industry, which use multiple economic indicators.
Faktor-Faktor yang Mempengaruhi Manajemen Pengolahan Makanan di Kantin SMP Kecamatan Galesong Selatan
Authors: Fitri A. Ulfiana , Ramadhani Nurul , Rhesa Muhammad , Hamid Muflih Wahid
Published: June 2024

Anak usia sekolah bebas memilih apa yang ingin ia makan tanpa memperhatikan kebersihan pengolahan makanannya. Apabila manajemen pengolahan makanan mulai dari memilih bahan, mengolah, menyimpan, mengangkut dan menyajikan tidak dilakukan dengan baik maka makanan yang dikonsumsi dapat menimbulkan dampak buruk. Penelitian ini bertujuan untuk mengetahui pengaruh karakteristik responden, pengetahuan dan sikap terhadap manajemen pengolahan makanan di kantin SMP Kecamatan Galesong Selatan. Penelitian ini adalah penelitian kuantitatif dengan desain cross sectional. Populasi dalam penelitian ini adalah seluruh pengolah makanan di SMPN 1 Galesong Selatan, SMPN 2 Galesong Selatan, SMPN 3 Galesong Selatan dan MTsS. Muhammadiyah Bontorita. Sampel pada penelitian ini berjumlah 31 orang atau semua populasi adalah sampel (total sampling). Hasil penelitian diperoleh dengan memberikan kuesioner kepada pengolah makanan di kantin. Melalui uji regresi linear sederhana didapat hasil analisis bivariat menunjukkan tidak terdapat pengaruh antara jenis kelamin (p=0,551), lama bekerja (p=0,551), pelatihan (p=0,535) dan pengetahuan (p=0,103) pengolah terhadap manajemen pengolahan makanan. Sedangkan terdapat pengaruh antara usia (p=0,49), Pendidikan (p=0,005) dan sikap (p=0,013) pengolah makanan terhadap manajemen pengolahan makanan. Hal ini dapat disimpulkan bahwa usia, pendidikan dan sikap merupakan faktor yang berpengaruh terhadap manajemen pengolahan makanan di Kantin SMP Kecamatan Galesong Selatan
Studi Kasus Pekerja CV. Batu Alam Terhadap Perspektif Mcclelland Teori Motivasi
Authors: Dhiyaul Haqqi Al-Mumtaza  , Mochammad Fiki
Published: June 2024

Employment opportunities are of course of many types, in this subject matter will take the phenomenon of Sumberwringin Village, in which there are mining activities, this mining activity is certainly a positive impact on the local community, because many think that the emergence or existence of a mine in their area will tend to help their income, this factor is what causes the community to agree to the existence of the mine. The mine, which began its activities in 2015, began to show its prestige by being recognized by other regions, in accordance with the study used, namely the existence of this new work activity can foster and increase a sense of solidarity with others and a sense of caring, not only this factor, there is a common motivation between people, namely many people whose economies are below, which makes people have the same opinion and agree to the existence of mining activities..
Peran Literasi Digital dalam Penguatan Profil Pelajar Pancasila Dimensi Mandiri, Bernalar Kritis, dan Kreatif
Authors: I Wayan Dede Putra Wiguna  , Ni Wayan Sudarti, S.Pd., M.Hum.
Published: June 2024

Digital literacy is becoming increasingly important in today's education, especially in developing student profiles that are independent, critical reasoning, and creative in the context of Pancasila. This study aims to describe the role of digital literacy in strengthening the profile of Pancasila students in these three dimensions. This research uses literature method to collect information from various related sources. The results showed that digital literacy has a significant role in strengthening and developing the profile of students who are independent, critical reasoning, and creative in the context of Pancasila. Digital literacy enables learners to access, evaluate, create, use information wisely, and communicate effectively through a variety of digital media. Thus, the integration of digital literacy in education can help strengthen the profile of Pancasila students in the independent, critical, and creative dimensions.
Smrt Borisa in Gleba kot poosebitev krščanskega političnega ideala in pojav vladarskih mučencev
Authors:   Catholic Institute, Faculty of Law and Economics, Malmenvall Simon ,   University of Ljubljana, Faculty of Theology
Published: June 2024

The princely brothers Boris and Gleb were the first canonized saints of Kievan Rus’. They respected the will of their elder brother, Sviatopolk, and voluntarily accepted their deaths in order to prevent further bloodshed and draw attention to the transience of earthly goods—in this case, political power. The martyrs of Rus’ were similar to the cases of princes Ludmila and Wenceslas of Bohemia, prince Jovan Vladimir of Dioclea, and Magnus Erlendsson, jarl (earl) of the Orkney Isles. All of the saints mentioned did not resort to revenge or fratricide as a means of struggle for power, but rather voluntarily accepted their deaths for the benefit of peace in their homelands. Ruler martyrs were regarded by their contemporaries as promoters of the new ideal of the Christian monarchs and as symbols of the rejection of the recent pagan past. This phenomenon, characteristic for the newly-Christianized lands on the eastern and northern periphery of Europe between the tenth and twelfth centuries, is also connected with the self-esteem of the ecclesiastical and secular elites—they saw their homelands, despite their relatively late adoption of Christianity, as culturally on equal footing with the other polities, which was to a large extent possible due to the emergence of the first local saints.
Prvi lastniki patidenčne hiše A na Gosposki ulici 10 in družina Peer v Ljubljani
Authors: Petelin David
Published: June 2024

Lazarini’s palace on Gosposka Street 10 in the middle of New Square (Novi trg) in Ljubljana hides within its walls a millennial history that can be traced from the culture of urn cemeteries, Roman and Medieval times, to the baroque adaptations and modern city structures. The archival sources are available to us for the surrounding area as early as the thirteenth century, when the religious community of the place was established, more eloquent are the sources from the sixteenth century onwards, when we can trace continuity of ownership until the present day. The first known owner of the house on today’s Gosposka street 10 was Christopher Peer. The Peer family was a well-known family in Carniola that originated from Gottschee (Kočevska). Many individuals of the surname Peer were also citizens of Ljubljana, one of them was even the mayor of Ljubljana in the mid-eighteenth century.
Piccolominijevo Pismo Mehmedu in krščanska lectio civilnega humanizma
Authors: Šček Jernej
Published: June 2024

In 1461 the Italian humanist Enea Silvio Piccolomini, pope Pius II, writes a famous letter to the Ottoman Sultan Mehmed the Conqueror, which is still quite unknown in the Slovenian academia. It reveals a complex and ambivalent, in fact an unquiet, mind, typical for the thought climate of the Late Middle Ages. It provides us a myriad of interesting historical, philosophical, sociological, philological and theological questions. This paper aims to contextualize this precious document in the field of historical humanism, problematize the late crusade ideology and search for relations with other irenic solutions. The Letter to Mehmed is a window on the world of the civil humanism meeting the active conception (vita activa) of the Christian humanism, which is the ultimate lesson of the early and middle Renaissance.
Hermeneutics of Gender: A Comparative Study of Hermeneutical Models Amina Wadud and Farid Esack
Authors: Ramadhan An Najmi Fikri
Published: June 2024

The aim of this research is to compare the hermeneutical models of Amina Wadud and Farid Esack. Hermeneutics is known as a new interpretive model used by Muslim feminist scholars, to reinterpret verses of the Koran that are interpreted textually and with gender bias. This research is qualitative research with the type of library research. Then the data collected in document form was analyzed using descriptive-comparative figures against Amina Wadud's hermeneutical model. The results of the research show that there are similarities and differences between the two hermeneutics. One of the most obvious similarities is that they both belong to philosophical hermeneutics and the objectiveist cum subjectivist school. Even though there are also differences between the two, the hermeneutic offer made by Amina Wadud and Farid Esack is an attempt jihad gender in seeking justice and freeing women from the patriarchal cultural system caused by religious interpretations that are biased against women.
Baitul Mal Aceh and Productive Zakat Education for Mustahiq
Authors: Sukmawati Muhammad Ichsan
Published: June 2024

There are eight groups of zakat recipients mentioned in the Koran. Without Baitul Mal Aceh's maximum role, especially in distributing productive Zakat, what the mustahiq receive may not be used productively. Zakat education is one of the things that can be done so that zakat recipients can really understand and make good use of the assistance. Therefore, Baitul Mal Aceh in particular has a very strategic role so that the zakat funds distributed to mustahiq, especially productive zakat, can really be utilized optimally and it is even hoped that the recipients will become muzakki in the future. Zakat education for mustahiq needs to continue to receive attention, including in terms of evaluating the provision of zakat. Religious education has an important role in providing understanding and awareness so that Muslims, especially mustahiq, become people who do not waste the wealth they have. The forms of education that can be given to them include: teaching knowledge about zakat, awakening their hearts with the light of faith, providing an understanding of zakat, and instilling in their hearts that using wealth well is part of worship.
Islam, Radicalism and Terrorism in the Perspective of the Qur'an: A Thematic Interpretive Study
Authors: Deva Noqita  , E. Siti Qoriatus Solihat  , Azzah At-Tauhid Faadiyatul
Published: June 2024

This study examines the relationship between Islam, radicalism, and terrorism from the perspective of the Qur'an using a thematic interpretation approach. The main focus is to understand how the Qur'an views and responds to issues related to radicalism and terrorism. This analysis includes an examination of relevant Qur'anic verses, particularly Surah Al-Hujurat verse 9 and Al-Maidah verse 33, which emphasize that radical and terrorist actions are not justified in Islam. The study also traces the historical and ideological roots of radicalism and terrorism in Islam, including the influence of Khawarij jurisprudence post the Battle of Siffin. In conclusion, the Qur'an strongly condemns acts of violence and extremism and underscores the importance of a correct and moderate understanding of religion to prevent the misuse of religious teachings.
INTELIGENCIA ARTIFICIAL Y PLUSVALÍA EN RED: UNA MIRADA SOBRE LA EXTRACCIÓN DEL BENEFICIO Y LAS NUEVAS REALIDADES TECNOLÓGICAS
Authors: Martínez Cabezudo Fernando
Published: June 2024

Con el desarrollo de IoT (internet de las cosas), el procesamiento de datos amplia tanto su complejidad como sus posibilidades de uso, entre los que destaca el desarrollo de la IA. Al mismo tiempo, se identifican una serie de efectos colaterales de esta tecnología que impactan en nuestra democracia. Los datos, y la forma en qué son procesados, conllevan riesgos para la ciudadanía, cuya amenaza principal es que sus nuestras vidas diarias sean vigiladas o intervenidas. No obstante, junto con estos conflictos, el IoT genera grandes beneficios para las sociedades en diversos campos como puede ser el sector industrial o el médico, sin olvidar las posibilidades ligadas a la mejora de la prevención de riesgos potenciales para las personas e infraestructuras. En cualquier caso, no se puede caer en su mitificación ni en el pesimismo. El papel de la regulación es esencial en esta profunda transformación tecnológica en la que nos encontramos. El IoT supone un verdadero desafío para la ciudadanía europea. La UE ha realizado un notable esfuerzo legislativo, que nos ha situado como el área del mundo con una legislación más avanzada en la protección de derechos en el ecosistema cibernético. Pero no es suficiente. Este libro ofrece no solo una evaluación de la situación actual, sino también realiza propuestas para construir una ciudadanía europea en la que la tecnología sea una aliada, no una amenaza.
Innovación docente y aprendizaje a través de la gamificación y la simulación: el modelo de la Unión Europea
Authors: Tomás López Ana
Published: June 2024

La innovación docente es esencial en una nueva forma de entender la Universidad. Desde la entrada en vigor de los planes Bolonia, se ha entendido que, junto con la enseñanza más tradicional, es necesario aportar nuevos métodos que dinamicen las aulas, y que conviertan a los estudiantes en actores activos del proceso de enseñanza. Desde el mercado laboral se exige que los profesionales del futuro, además de ser expertos en sus respectivas áreas de conocimiento, tengan ciertas habilidades de forma transversal, como el pensamiento crítico, la capacidad de trabajo en equipo o la adaptación a distintos entornos. Para lograr todo esto, los profesores universitarios están poniendo en marcha distintos tipos de innovaciones docentes, algunas de las cuales se comparten en los capítulos que conforman esta obra, que pretende convertirse en una ayuda para todos aquellos docentes de las diferentes disciplinas que se imparten en las facultades de Ciencias Sociales y Jurídicas.
Tinjauan Terhadap Surat Al-Maidah ayat 67 dan Surat An-Nahl ayat 125 tentang Metode Pendidikan Dalam Al-Qur'an
Authors: Fitri Mega , Junaidi Riskan , Saputra Hasep , Rahman Abdul
Published: June 2024

Penelitian ini membahas mengenai dinamika dan metode pendidikan daa alquran dan sunnah, tujuan dari penelitian ini adalah untuk mengetahui metode pendidikan dalam quran bila di tinjau dalam surah al-maidah 67 dan an-nahl 125, sumber primer dan sumber sekunder, Sumber data primer dalam penelitian ini menggunakan buku tafisr serta pendidikan dan data sekunder yang di gunakan jurnal dan buku buku yang relavan, hasil penelitian ini menunjukan Surat Al-Maidah ayat 67 dan Surat An-Nahl ayat 125 menunjukkan bahwa Al-Qur'an dan Sunnah memberikan pedoman yang jelas mengenai metode pendidikan dalam Islam. Metode pendidikan yang dianjurkan mencakup penggunaan pendekatan yang bijaksana (hikmah), nasihat yang baik (mauizhah al-hasanah), dan dialog (diskusi serta pertanyaan) yang relevan dengan situasi dan kondisi. Pendekatan ini mencerminkan fleksibilitas dan adaptabilitas dalam proses pembelajaran, memastikan pesan agama disampaikan dengan efektif dan diterima oleh umat. Selain itu, metode-metode ini juga menekankan pembentukan karakter dan moral yang baik, menjadikannya integral dalam pengajaran dan pembelajaran Islam yang efektif..
Peran Hamba Tuhan dalam Mengantisipasi Perceraian di Dalam Gereja
Authors: Siregar Saroha Ida Ike
Published: June 2024

Keluarga adalah sebuah bentuk komunitas yang penting dalam suatu pondasi yang dapat diterapkan bagi nilai-nilai agama dan budaya yang membantu seseorang menemukan identitasnya sendiri karena keluarga didirikan atas dasar cinta dan keterbukaan  terhadap anugerah Tuhan dalam kehidupan. Umumnya masyarakat berpandangan bahwa pernikahan dilaksanakan sebagai syarat hukum, adat, Negara dan agama. Bagi orang Kristen pemahaman yang benar tentang pernikahan harus didasarkan pada Alkitab. Dengan menggunakan pendekatan deskriptif kualitatif, tulisan ini memaparkan mengenai Peran Hamba Tuhan dalam mengantisipasi perceraian dalam gereja. Hamba Tuhan harus mengetahui keberadaan keluarga-keluarga yang bercerai ditengah jemaat dan masyarakatHasil temuan adalah Kewajiban seorang Hamba Tuhan adalah menunjukkan pengertian pergumulan yang dihadapi jemaat di dalam gereja. Dalam pernikahan peran Hamba Tuhan sangatlah penting bagi jemaatnya agar tidak terjadi perceraian. Karena sebelum memasuki pernikahan, hamba Tuhan lebih dahulu harus memberikan pengarahan kepada kedua mempelai supaya mempersiapkan diri untuk masuk dalam pernikahan. Apabila kedua mempelai itu sudah memperdalam pengetahuan tentang iman satu sama lain maka tiap-tiap orang tinggal dalam imannya sendiri.
Pengajaran Mempelai Sebagai Solusi Disharmonisasi Rumah Tangga Kristen di Kelurahan Hinekombe Jayapura- Papua
Authors: Markus S. Gainau  , Talo Amsi
Published: June 2024

Disharmonisasi dalam rumah tangga bukan lagi menjadi fenomena baru yang dihadapi keluarga akhir-akhir ini. Berbagai usaha sudah dilakukan oleh pemerintah sampai pada penerbitan UU untuk menekan disharmonisasi. Penelitian ini berusaha untuk mengelaborasikan mengenai faktor kontekstual penyebab terjadinya disharmonisasi dalam rumah tangga pada masyarakat Hinekombe Sentani-Jayapura. Metode yang digunakan dalam mengungkap fakta adalah metode deskriptif kualitatif. Teknik yang digunakan untuk mengumpulkan data adalah teknik FGD yaitu berupa diskusi terarah terhadap 28 informan kemudian dilanjutkan dengan teknik IDI yaitu interview mendalam terhadap 11 Informan lokal. Hasil dari penelitian ini menunjukkan bahwa terjadinya disharmonisasi  secara kontekstual dalam rumah tangga dipicuh karena faktor ikatan pernikahan. Ikatan Pernikahan yang dilakukan masyarakat sebelumnya adalah ikatan pernikahan adat yang tidak melalui pernikahan Gereja atau diluar dari pernikahan kudus. Secara implisit bahwa pernikahan adat adalah pernikahan menurut kedagingan yang berbentuk dosa Zinah. Usaha penanaman mentalitas pengajaran mempelai memberikan sikap yang positif berupa pemahaman, pengakuan dosa, dan pertobatan.
Sumbangsih Keteledanan Paulus Terhadap Guru Pendidikan Agama Kristen
Authors: Yanuar Ada Zega  , Nome Nehemia
Published: June 2024

Keteladanan Pendidik Kristen merupakan suatu modelling bagi peserta didik dalam mengembangkan kognitif, afektif, dan psikomotorik. Kelalaian pendidik Kristen saat ini kurangnya kesesuaian antara kata dan fakta. Pentingnya keselarasan antara kata dengan perbuatan sangat berpengaruh besar bagi seorang pendidik kepada peserta didik. Penelitian ini menggunakan pendekatan penelitian kualitatif dengan pendekatan studi kepustakaan atau literatur melalui penelusuran teori-teori dan hasil penelitian yang berkaitan dengan kehidupan Rasul Paulus sebagai pendidik jemaat. Tujuan dari penelitian ini adalah mengeksplorasikan keteladanan Rasul Paulus dan kedekatan dirinya kepada Tuhan yang lebih dulu melakukan hal-hal penting dalam pengajaran, semestinya pendidik mampu dalam beberapa aspek: wawasan yang luas sebagai dasar utama dalam pengajarannya, kecakapan sebagai suatu implementasi praktis yang mudah dipahami, kevisioneran yang bersifat preventif dan antisipatif dalam mengahadapi masa dinamika yang datang dalam pertumbuhan iman jemaat dan peserta didik.
Paul, Christian Education, Exemplary
Valuing co-operation: motivation and reward for producers of education platform content
Authors:   , Connolly Darren
Published: June 2024

The seed of this research comes from a desire to understand alternative routes to building sustainable online businesses, where workers are at the heart of planning, control and decision making. To challenge the dominance of global players on the internet, businesses underpinned by neoliberal thought. The purpose of this thesis is to assist in filling the void in the current literature with regard to the motivation and reward for individual producers of education videos for online platforms, to explore the value of co-operation amongst producers, and the potential role of co-operative principles. An inductive, qualitative, interpretive approach was used to gather empirical data on individual producers. Online semi-structured interviews were carried out with twenty producers within three comparative case studies: internal (employed), external (self-employed) and co-producers (employed or self-employed). Critical Systems Theory provided the authenticity to question producers’ perceptions of existing systems and the paradigm out of which platforms and producers operate. A methodological contribution comes from utilising Meadows’ taxonomy of systemic intervention points as a theoretical framework to identify potential system levers in reward systems. This research provides insights into what workers value in a platform relationship and the implications of this for reward systems. The research identified distinct motivators and reward management practices specific to producer groups, as well as underlying features that were common across all producer groups. If new systems are to challenge the existing stranglehold of venture capitalist backed platforms they will benefit from open platform membership, worker participation in both systems development and reward ownership, and worker autonomy and independence. This research provides a scope for change, so that individual content producers can see for themselves the possibilities to self-organise into new forms. A limitation of this research is that data collected was based on the perspectives of individual producers, future research could include other actors to provide a rich picture of platform systems. It also does not fully address the capital problem of how to finance internet based businesses, but with worker-centric platform businesses there is a foundation for research into the integration of existing multistakeholder models
On the history of the creation of the Old Moscow Commission: what the archival documents told about
Authors: Zasedateleva Nina Nikolaevna
Published: June 2024

The subject of this article is the Commission for the Study of Old Moscow, which was formed at the Imperial Moscow Archaeological Society and continued to operate after the liquidation of the IMAO. The author pays special attention to the Rules of the Commission, a program document of this community, which have been preserved both in handwritten and printed form, and in several copies. In addition, the author examines other archival documents – minutes of the Commission's meetings, which allow to highlight the issue of the activities and work of the Commission. The study of these documents also helps to understand how the Commission for the Study of Old Moscow was organized, who held the main positions and what responsibilities were imposed on them, who were the most active members of the Commission, etc. The main method of research is the method of historical analysis, which allows one to analyze the minutes of meetings and Rules of the Commission for the Study of Old Moscow and on their basis to understand how this community functioned. The main conclusions of the conducted research are, firstly, the conclusion that by 1917 the Commission for the Study of Old Moscow had become a serious scientific society, which included not only those interested in the history of Moscow, amateur Muscovites, but also professional historians, archivists, architects, etc.; secondly, the conclusion about the Commission's huge contribution to the study and preservation of ancient monuments in Moscow. In addition, the author concludes that the Commission for the Study of Old Moscow was institutionally and in many types of activities the successor of the Imperial Moscow Archaeological Society. Preserving the traditions of the IMAO and remaining faithful to its basic principles, the Commission was able to continue its activities after the liquidation of the IMAO. The novelty of the research lies in the introduction into scientific circulation of previously unpublished archival sources, a comprehensive analysis of which allows us to reconstruct the daily life of the Commission.
Arabidopsis transcriptome responses to low water potential using high throughput plate assays
Authors: Gonzalez Stephen , Swift Joseph , Yaaran Adi , Xu Jiaying , Miller Charlotte , Illouz-Eliaz Natanella , Nery Joseph R. , Busch Wolfgang , Zait Yotam , Ecker Joseph R.
Published: June 2024

Soil-free assays that induce water stress are routinely used to investigate drought responses in the plant
Arabidopsis thaliana
. Due to their ease of use, the research community often relies on polyethylene glycol (PEG), mannitol and salt (NaCl) treatments to reduce the water potential of agar media, and thus induce drought conditions in the laboratory. However, while these types of stress can create phenotypes that resemble those of water deficit experienced by soil-grown plants, it remains unclear how these treatments compare at the transcriptional level. Here, we demonstrate that these different methods of lowering water potential elicit both shared and distinct transcriptional responses in
Arabidopsis
shoot and root tissue. When we compared these transcriptional responses to those found in
Arabidopsis
roots subject to vermiculite drying, we discovered many genes induced by vermiculite drying were repressed by low water potential treatments on agar plates (and vice versa). Additionally, we also tested another method for lowering water potential of agar media. By increasing the nutrient content and tensile strength of agar, we show the ‘hard agar’ (HA) treatment can be leveraged as a high-throughput assay to investigate natural variation in
Arabidopsis
growth responses to low water potential.
Risk factors affecting polygenic score performance across diverse cohorts
Authors: Hui Daniel , Dudek Scott , Kiryluk Krzysztof , Walunas Theresa L. , Kullo Iftikhar J. , Wei Wei-Qi , Tiwari Hemant K. , Peterson Josh F. , Chung Wendy K. , Davis Brittney , Khan Atlas , Kottyan Leah , Limdi Nita A. , Feng Qiping , Puckelwartz Megan J. , Weng Chunhua , Smith Johanna L. , Karlson Elizabeth W. , Center Regeneron Genetics , Jarvik Gail P. , Ritchie Marylyn D.
Published: June 2024

Apart from ancestry, personal or environmental covariates may contribute to differences in polygenic score (PGS) performance. We analyzed effects of covariate stratification and interaction on body mass index (BMI) PGS (PGS
BMI
) across four cohorts of European (N=491,111) and African (N=21,612) ancestry. Stratifying on binary covariates and quintiles for continuous covariates, 18/62 covariates had significant and replicable R
2
differences among strata. Covariates with the largest differences included age, sex, blood lipids, physical activity, and alcohol consumption, with R
2
being nearly double between best and worst performing quintiles for certain covariates. 28 covariates had significant PGS
BMI
-covariate interaction effects, modifying PGS
BMI
effects by nearly 20% per standard deviation change. We observed overlap between covariates that had significant R
2
differences among strata and interaction effects – across all covariates, their main effects on BMI were correlated with their maximum R
2
differences and interaction effects (0.56 and 0.58, respectively), suggesting high-PGS
BMI
individuals have highest R
2
and increase in PGS effect. Using quantile regression, we show the effect of PGS
BMI
increases as BMI itself increases, and that these differences in effects are directly related to differences in R
2
when stratifying by different covariates. Given significant and replicable evidence for context-specific PGS
BMI
performance and effects, we investigated ways to increase model performance taking into account non-linear effects. Machine learning models (neural networks) increased relative model R
2
(mean 23%) across datasets. Finally, creating PGS
BMI
directly from GxAge GWAS effects increased relative R
2
by 7.8%. These results demonstrate that certain covariates, especially those most associated with BMI, significantly affect both PGS
BMI
performance and effects across diverse cohorts and ancestries, and we provide avenues to improve model performance that consider these effects.
Episodic boundaries affect neural features of representational drift in humans
Authors: Kulkarni Nimay , Lega Bradley C.
Published: June 2024

A core feature of episodic memory is representational drift, the gradual change in aggregate oscillatory features that supports temporal association of memory items. However, models of drift overlook the role of episodic boundaries, which indicate a shift from prior to current context states. Our study focuses on the impact of task boundaries on representational drift in the parietal and temporal lobes in 99 subjects during a free recall task. Using intracranial EEG recordings, we show boundary representations reset gamma band drift in the medial parietal lobe, selectively enhancing the recall of early list (primacy) items. Conversely, the lateral temporal cortex shows increased drift for recalled items but lacked sensitivity to task boundaries. Our results suggest regional sensitivity to varied contextual features: the lateral temporal cortex uses drift to differentiate items, while the medial parietal lobe uses drift-resets to associate items with the current context. We propose drift represents relational information tailored to a region’s sensitivity to unique contextual elements. Our findings offer a mechanism to integrate models of temporal association by drift with event segmentation by episodic boundaries.
Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases
Authors: Koh Duk-Su , Stratiievska Anastasiia , Jana Subhashis , Otto Shauna C. , Swanson Teresa M. , Nhim Anthony , Carlson Sara , Raza Marium , Naves Lígia Araujo , Senning Eric N. , Mehl Ryan , Gordon Sharona E.
Published: June 2024

Ligands such as insulin, epidermal growth factor, platelet derived growth factor, and nerve growth factor (NGF) initiate signals at the cell membrane by binding to receptor tyrosine kinases (RTKs). Along with G-protein coupled receptors, RTKs are the main platforms for transducing extracellular signals into intracellular signals. Studying RTK signaling has been a challenge, however, due to the multiple signaling pathways to which RTKs typically are coupled, including MAP/ERK, PLCγ, and Class 1A phosphoinositide 3-kinases (PI3K). The multi-pronged RTK signaling has been a barrier to isolating the effects of any one downstream pathway. Here, we used optogenetic activation of PI3K to decouple its activation from other RTK signaling pathways. In this context, we used genetic code expansion to introduce a click chemistry noncanonical amino acid into the extracellular side of membrane proteins. Applying a cell-impermeant click chemistry fluorophore allowed us to visualize delivery of membrane proteins to the plasma membrane in real time. Using these approaches, we demonstrate that activation of PI3K, without activating other pathways downstream of RTK signaling, is sufficient to traffic the TRPV1 ion channels and insulin receptors to the plasma membrane.
Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome
Authors: Lopes Filipa M. , Grenier Celine , Jarvis Benjamin W. , Mahdy Sara Al , Lène-McKay Adrian , Gurney Alison M. , Newman William G. , Waddington Simon N. , Woolf Adrian S. , Roberts Neil A.
Published: June 2024

Rare early onset lower urinary tract disorders include defects of functional maturation of the bladder. Current treatments do not target the primary pathobiology of these diseases. Some have a monogenic basis, such as urofacial, or Ochoa, syndrome (UFS). Here, the bladder does not empty fully because of incomplete relaxation of its outflow tract, and subsequent urosepsis can cause kidney failure. UFS is associated with biallelic variants of
HPSE2
, encoding heparanase-2. This protein is detected in pelvic ganglia, autonomic relay stations that innervate the bladder and control voiding. Bladder outflow tracts of
Hpse2
mutant mice display impaired neurogenic relaxation. We hypothesized that
HPSE2
gene transfer soon after birth would ameliorate this defect and explored an adeno-associated viral (
AAV
) vector-based approach.
AAV9/HPSE2,
carrying human
HPSE2
driven by
CAG
, was administered intravenously into neonatal mice. In the third postnatal week, transgene transduction and expression were sought, and
ex vivo
myography was undertaken to measure bladder function. In mice administered
AAV9/HPSE2
, the viral genome was detected in pelvic ganglia. Human
HPSE2
was expressed and heparanase-2 became detectable in pelvic ganglia of treated mutant mice. On autopsy, wild-type mice had empty bladders whereas bladders were uniformly distended in mutant mice, a defect ameliorated by
AAV9/HPSE2
treatment. Therapeutically,
AAV9/HPSE2
significantly ameliorated impaired neurogenic relaxation of
Hpse2
mutant bladder outflow tracts. Impaired neurogenic contractility of mutant detrusor smooth muscle was also significantly improved. These results constitute first steps towards curing UFS, a clinically devastating genetic disease featuring a bladder autonomic neuropathy.
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
Authors: Li Bing , Suresh Prasanna , Brelstaff Jack , Kedia Shekhar , Bryant Clare E , Klenerman David
Published: June 2024

The Myddosome is a key innate immune signalling platform. It forms at the cell surface and contains MyD88 and IRAK proteins which ultimately coordinate the production of pro-inflammatory cytokines. Toll-like receptor 4 (TLR4) signals via the Myddosome when triggered by lipopolysaccharide (LPS) or amyloid-beta (Aβ) aggregates but the magnitude and time duration of the response are very different for reasons that are unclear. Here, we followed the formation of Myddosomes in live macrophages using local delivery of TLR4 agonist to the cell surface and visualisation with 3D rapid light sheet imaging. This was complemented by super-resolution imaging of Myddosomes in fixed macrophages to determine the size of the signalling complex at different times after triggering. Myddosomes formed more rapidly after LPS than in response to sonicated Aβ 1–42 fibrils (80 vs 372 s). The mean lifetimes of the Myddosomes were also shorter when triggered by LPS compared to sonicated Aβ fibrils (170 and 220 s), respectively. In both cases, a range of Myddosome of different sizes (50–500 nm) were formed. In particular, small round Myddosomes around 100 nm in size formed at early time points, then reduced in proportion over time. Collectively, our data suggest that compared to LPS the multivalency of Aβ fibrils leads to the formation of larger Myddosomes which form more slowly and, due to their size, take longer to disassemble. This explains why sonicated Aβ fibrils results in less efficient triggering of TLR4 signalling and may be a general property of protein aggregates.
Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity
Authors: Yu Hong , Nishio Hiroshi , Barbi Joseph , Mitchell-Flack Marisa , Vignali Paolo D. A. , Zheng Ying , Lebid Andriana , Chang Kwang-Yu , Fu Juan , Higgins Makenzie , Huang Ching-Tai , Zhang Xuehong , Li Zhiguang , Blosser Lee , Tam Ada , Drake Charles G. , Pardoll Drew M.
Published: June 2024

The adaptive T cell response is accompanied by continuous rewiring of the T cell’s electric and metabolic state. Ion channels and nutrient transporters integrate bioelectric and biochemical signals from the environment, setting cellular electric and metabolic states. Divergent electric and metabolic states contribute to T cell immunity or tolerance. Here, we report that neuritin (Nrn1) contributes to tolerance development by modulating regulatory and effector T cell function. Nrn1 expression in regulatory T cells promotes its expansion and suppression function, while expression in the T effector cell dampens its inflammatory response. Nrn1 deficiency causes dysregulation of ion channel and nutrient transporter expression in Treg and effector T cells, resulting in divergent metabolic outcomes and impacting autoimmune disease progression and recovery. These findings identify a novel immune function of the neurotrophic factor Nrn1 in regulating the T cell metabolic state in a cell context-dependent manner and modulating the outcome of an immune response.
Artificial Intelligence and Digital Pathology: A Narrative Review on Advancements and Opportunities for Improved Diagnosis and Treatment
Authors: Dhamapurkar Madhura Umesh , Barbade Ratanprabha Dhanraj , Meghana SM , Kulkarni Sandip , Godge Pournima
Published: June 2024

Recent advancements in Digital Pathology (DP) have empowered pathologists to provide more accurate diagnosis through digital means. Whole-slide Imaging (WSI) technology has enabled the digital scanning, representation, and preservation of numerous tissue slides, while Artificial Intelligence (AI), image analysis, and Machine Learning (ML) have enhanced disease diagnosis accuracy. There is a growing acceptance of the transition from traditional glass slide histopathological diagnosis to AI-assisted diagnosis using digital slides, driven by the substantial data accumulation that demands computer-aided analysis. Maximising the potential of AI breakthroughs in DP is critical, offering significant research opportunities across related fields. DP offers significant potential for telepathology, second opinions, and educational purposes. Additionally, it presents substantial research opportunities in image computing due to its vast reservoir of data. Pathologists have discerned characteristics beyond the naked eye’s perception by analysing “sub-visual” images using DP. The flexibility of workflow provided by DP will be the main reason for its widespread adaptation and acceptance. DP also has the potential to be an essential tool to maintain operations of the pathology department in case of public health emergencies, which will streamline, fast-track, and improve patient care. Given the expanding accessibility and prevalence of the internet, it is crucial to develop innovations like DP. This technology catalyses enhancing patient care, opening avenues for further advancements in healthcare delivery. The purpose of present review was to bring to light the great potential that DP encompasses to improve diagnosis and treatment planning, which will ultimately lead to better patient care. However, integrating DP systems necessitates collaboration from various stakeholders beyond the Pathology Department. Despite evident advantages, several challenges must be addressed for the successful implementation and mass acceptance. Therefore, this narrative review aimed to illuminate the substantial potential inherent in DP for enhancing both diagnosis and treatment planning processes, consequently fostering improvements in patient care and also understanding DP, highlighting its challenges and opportunities. It also delves into the role of AI, image analysis, and ML in aiding disease diagnosis and reporting. With social distancing measures in place during the Coronavirus Disease -2019 (COVID-19) pandemic, pathologists were able to remotely access and analyse DP images, further cementing the importance of DP in current scenarios.
Effect of Snapping Roller Parameters on Maize Harvesting
Authors: J Pargi Sanjay , Gupta Pankaj , Balas P. R. , Bambhaniya V. U. , Dabhi K. L. , Salunkhe R. C.
Published: June 2024

The effectiveness of maize harvesting is significantly impacted by the parameters of snapping rollers, which have a crucial function in separating maize ears from the stalks. The present study examines the influence of several snapping roller parameters, such as rotational speed, roller spacing, and surface properties, on the efficiency of maize harvesting. The paper provides a detailed examination of the advancements in snapping roller technology, focusing on improvements that seek to optimize performance and minimize harm to crops. The research highlights significant obstacles, including the need for wear resistance, careful material selection, and the capacity to adapt to various maize kinds. The suggested solutions to these difficulties include the use of improved materials, optimal roller designs, and adaptive control systems. Addressing these difficulties may lead to a substantial improvement in the efficiency and sustainability of maize harvesting operations, as shown by the data. This study offers vital insights for the development of more efficient and durable maize harvesting machinery, eventually leading to enhanced agricultural output and food security.