bluuebunny/crossref_metadata_2025 huggingface dataset:
From multi-omics integration towards novel genomic interaction networks to identify key cancer cell line characteristics
Authors: Kuijpers T. J. M. , Kleinjans J. C. S. , Jennen D. G. J.
Published: May 2021

Cancer is a complex disease where cancer cells express epigenetic and transcriptomic mechanisms to promote tumor initiation, progression, and survival. To extract relevant features from the 2019 Cancer Cell Line Encyclopedia (CCLE), a multi-layer nonnegative matrix factorization approach is used. We used relevant feature genes and DNA promoter regions to construct genomic interaction network to study gene–gene and gene—DNA promoter methylation relationships. Here, we identified a set of gene transcripts and methylated DNA promoter regions for different clusters, including one homogeneous lymphoid neoplasms cluster. In this cluster, we found different methylated transcription factors that affect transcriptional activation of EGFR and downstream interactions. Furthermore, the hippo-signaling pathway might not function properly because of DNA hypermethylation and low gene expression of both LATS2 and YAP1. Finally, we could identify a potential dysregulation of the CD28-CD86-CTLA4 axis. Characterizing the interaction of the epigenome and the transcriptome is vital for our understanding of cancer cell line behavior, not only for deepening insights into cancer-related processes but also for future disease treatment and drug development. Here we have identified potential candidates that characterize cancer cell lines, which give insight into the development and progression of cancers.
Impacts may provide heat for aqueous alteration and organic solid formation on asteroid parent bodies
Authors: Yasui Minami , Tazawa Taku , Hashimoto Ryohei , Arakawa Masahiko , Ogawa Kazunori
Published: May 2021

Chemical reactions on asteroid parent bodies, such as aqueous alteration and the formation of organic solids, require a heat source. Radioactive decay in the interiors of these bodies is generally considered the most important heat source, but impact-generated heating is also likely to play a role. Here we present high-velocity impact cratering experiments using thermocouples embedded in the target material to directly measure the spatial and temporal evolution of temperature throughout each impact experiment. We find that the maximum temperature below the crater floor scales with the distance from the impact point, while the duration of temperature rise is scaled by the thermal diffusion time. We use numerical modelling to suggest that, at distances within 2 astronomical units, impacts producing craters of >20 km radius can facilitate aqueous alteration in the material below the crater, while those which produce craters of 1 km radius can support organic solid formation.
Small rings in the bigger picture: ring expansion of three- and four-membered rings to access larger all-carbon cyclic systems
Authors: Biletskyi Bohdan , Colonna Pierre , Masson Kévin , Parrain Jean-Luc , Commeiras Laurent , Chouraqui Gaëlle
Published: May 2021

Ring-expansion of strained small-size rings to forge larger all-carbon ones, allows a rapid build-up of molecular complexity.
Nitrogen and copper-doped carbon quantum dots with intrinsic peroxidase-like activity for double-signal detection of phenol
Authors: Du Jinyan , Qi Shuangqing , Fan Tingting , Yang Ying , Wang Chaofeng , Shu Qin , Zhuo Shujuan , Zhu Changqing
Published: May 2021

Using the oxidative coupling reaction of phenol with 4-AAP in the presence of H2O2 catalyzed by N, Cu-CQDs with an intrinsic peroxidase-like activity, a new sensing system with double signals was constructed for the detection of phenol.
Magnetic covalent organic framework nanocomposites as a new adsorbent for the determination of polycyclic aromatic hydrocarbons in water and food samples
Authors: Wu Hao , Li Derong , Zhao Bingxin , Guan Shuping , Jing Xu , Ding Yufang , Fan Gaili
Published: May 2021

The schematic fabrication process of Fe3O4@COF(Tp-NDA) and the application to MSPE.
A hybridization-based dual-colorimetric kit for circulating cancer miRNA detection
Authors: Zhou Ping , Gong Shaohua , Liu Bo , Shi Mingwan , Lu Fei , Li Na , Tang Bo
Published: May 2021

A dual-colorimetric miRNA detection kit that can simultaneously detect two miRNAs with high sensitivity and selectivity is developed, which is able to achieve the rapid detection of lung cancer using clinical serum samples.
The molecular behavior of pyridinium/imidazolium based ionic liquids and toluene binary systems
Authors: Chen Hong , Wang Zonghua , Xu Xianzhen , Gong Shida , Zhou Yu
Published: May 2021

EMIMTFSI/BpyTFSI and benzene rings formed C–H⋯π bonds, which played a crucial role in capturing aromatic compounds.
Nanostructured metal phosphides: from controllable synthesis to sustainable catalysis
Authors: Li Shao-Hai , Qi Ming-Yu , Tang Zi-Rong , Xu Yi-Jun
Published: May 2021

Metal phosphides (MPs) with unique and desirable physicochemical properties provide promising potential in implementable sustainable catalytic fields including electrocatalysis, photocatalysis, mild thermocatalysis, and interdisciplinary hybrid systems.
Telling the important stories of “no adverse effect” nanomaterials data
Authors: Lynch Iseult , Klaper Rebecca
Published: May 2021

Exploring the no-adverse effect responses to nanomaterials with a well-designed no adverse effects study will provide insights into the “why?” of the no adverse effect.
High yield electrooxidation of 5-hydroxymethyl furfural catalysed by unsaturated metal sites in CoFe Prussian Blue Analogue films
Authors: Hadinata Lie William , Deng Chen , Yang Yuwei , Tsounis Constantine , Wu Kuang-Hsu , Chandra Hioe Maria Veronica , Bedford Nicholas M. , Wang Da-Wei
Published: May 2021

Unsaturated Co metal sites in CoFe Prussian blue analogues are introduced by pulse electrodeposition on Ni foam. The PBA electrode achieved 94% yield of 2,5-furandicarboxylic acid from 5-hydroxymethylfurfural at 1.43 V vs. RHE.
Self-defect-healing of silicalite-1 membrane in alkaline aqueous solution with surfactant
Authors: Sakai Motomu , Hori Hayata , Matsukata Masahiko
Published: May 2021

Alkaline treatment with surfactant was applied to silicalite-1 membrane for defect healing.
Electrodeposition of hybrid nanosheet-structured NiCo2O4 on carbon fiber paper as a non-noble electrocatalyst for efficient electrooxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid
Authors: Zhong Yan , Ren Ru-Quan , Qin Lei , Wang Jian-Bo , Peng Yi-Yi , Li Qiang , Fan Yong-Ming
Published: May 2021

Hybrid nanosheet-structured NiCo2O4 on CFP as a self-supporting electrode for electrochemical oxidation of HMF to FDCA.
Wide-area multilayered self-assembly of fluorapatite nanorods vertically oriented on a substrate as a non-classical crystal growth
Authors: Hagiwara Yuki , Oaki Yuya , Imai Hiroaki
Published: May 2021

Micrometer-thick flat films were successfully deposited through homogeneous stacking of vertical fluorapatite nanorods on a substrate with a diameter of over 20 mm.
4.9% Au stabilizes Ag in an atomically homogenous bimetallic alloy for anisotropic nanocrystals with enhanced stability under light irradiation
Authors: Xu Zhenying , Xie Hao , Ye Weixiang , Yang Yi , Ni Weihai
Published: May 2021

Atomically homogenous AuAg alloy nanocrystals with Au fraction as low as 4.9% (at%) possesses a comparable stability to Au, while the superior plasmonic properties of Ag are largely reserved.
Organic synthesis via Kolbe and related non-Kolbe electrolysis: an enabling electro-strategy
Authors: Sbei Najoua , Aslam Samina , Ahmed Nisar
Published: May 2021

Herein, the electrolysis process, where the anodic oxidation of carboxylic acids leads to decarboxylation, has been discussed to synthesize organic molecules.
Recent advances in activity-based probes (ABPs) and affinity-based probes (AfBPs) for profiling of enzymes
Authors: Fang Haixiao , Peng Bo , Ong Sing Yee , Wu Qiong , Li Lin , Yao Shao Q.
Published: May 2021

This review highlights the recent advances in the use of activity-based probes (ABPs) and affinity-based probes (AfBPs), and summarizes their design strategies (based on inhibitors and substrates) and detection approaches.
Sensory Responsiveness Is Linked With Communication in Infant Siblings of Children With and Without Autism
Authors: Feldman Jacob I. , Raj Sweeya , Bowman Sarah M. , Santapuram Pooja , Golden Alexandra J. , Daly Claire , Dunham Kacie , Suzman Evan , Augustine Ashley E. , Garla Varsha , Muhumuza Aine , Cascio Carissa J. , Williams Kathryn L. , Kirby Anne V. , Keceli-Kaysili Bahar , Woynaroski Tiffany G.
Published: May 2021

Purpose

Differences in communication development impact long-term outcomes of children with autism. Previous research has identified factors associated with communication in children with autism, but much of the variance in communication skill remains unexplained. It has been proposed that early differences in sensory responsiveness (i.e., hyporesponsiveness, hyperresponsiveness, and sensory seeking) may produce “cascading effects” on communication. Evidence for this theory is limited, however, as relations between sensory responsiveness and communication in the earliest stages of development have not been well established. The purpose of this study was to evaluate (a) whether infants with a heightened likelihood of autism diagnosis (i.e., infants with an older sibling with autism) differ from infants at general population–level likelihood of autism (i.e., infants with an older, nonautistic sibling) on patterns of sensory responsiveness, (b) whether early sensory responsiveness is correlated with concurrent communication, and (c) whether the aforementioned between-groups differences and associations are moderated by age.

Method

Participants were 40 infants (20 infants with an older sibling with autism, 20 infants with an older, nonautistic sibling) aged 12–18 months. A series of observational and parent report measures of sensory responsiveness and communication skill were administered.

Results

Group differences in sensory responsiveness across the 12- to 18-month period were limited (i.e., only observed for one measure of hyporesponsiveness), though selected differences in sensory responsiveness (i.e., parent-reported hyperresponsiveness and sensory seeking) emerged between groups over this developmental window. Parent-reported hyporesponsiveness was unconditionally, negatively associated with communication skills. Associations between expressive communication and (a) parent-reported sensory seeking and (b) an observational measure of hyperresponsiveness were moderated by age.

Conclusions

This study provides new insights into the nature of sensory responsiveness and theorized links with communication skill in infants at elevated and general population–level likelihood of autism diagnosis. Further work is needed to better characterize the effects of interest in a larger sample spanning a wider age range.

Supplemental Material

https://doi.org/10.23641/asha.14515542
Les nouvelles maladies héréditaires du métabolisme du programme français de dépistage néonatal
Authors: Touati Guy , Gorce Magali , Oliver-Petit Isabelle , Broué Pierre , Ausseil Jérôme
Published: May 2021

Les maladies héréditaires du métabolisme (MHM) sont un groupe de maladies rares et cliniquement hétérogènes. Le retard diagnostique est fréquent, conduisant souvent au décès du patient ou à de graves séquelles. Certaines MHM entraînent l’accumulation de métabolites intermédiaires circulant dans le sang, qui sont détectables par une méthode commune utilisant la spectrométrie de masse en tandem. Cette méthode permet la reconnaissance simultanée de plusieurs de ces maladies affectant différentes voies métaboliques. En France, le programme de dépistage néonatal (DNN) des MHM, longtemps limité à la phénylcétonurie, a récemment été étendu au déficit en déshydrogénase des acyl-CoA à chaîne moyenne (MCADD). Le rationnel, la méthode et l’organisation de ce nouveau DNN sont décrits dans cet article. Sept nouvelles MHM (leucinose, homocystinurie, tyrosinémie de type I, acidurie glutarique de type I, acidurie isovalérique, déficit en déshydrogénase des hydroxy-acyl-CoA à chaîne longue, déficit du transporteur de la carnitine) devraient être dépistées, grâce à une prochaine extension du programme de DNN. Des efforts sont nécessaires pour mieux comprendre et prévoir la signification de chaque test anormal à la naissance, diminuer les taux de faux positifs, et développer les stratégies de prise en charge adéquates.
Dépistage néonatal en Europe
Authors: Loeber J. Gerard , Platis Dimitris , Zetterström Rolf H. , Schielen Peter J.C.I.
Published: May 2021

Le dépistage néonatal a débuté en Europe dans les années 1960 avec celui de la phénylcétonurie. Le nombre de maladies dépistées a, par la suite, augmenté progressivement, de manière plus marquée à la fin des années 1990 avec l’arrivée de la spectrométrie de masse en tandem (MS/MS) qui a permis le dépistage de 40 à 50 maladies sur une seule goutte de sang séché. Les ajouts les plus récents à cette liste de maladies (mucoviscidose, déficits immunitaires combinés sévères et atrophie musculaire spinale) ont été rendus possibles grâce à la génétique moléculaire. À partir des informations provenant de 51 pays d’Europe, nous décrivons dans cette revue l’évolution du dépistage entre 2010 et 2020, ainsi que les progrès réalisés pendant cette période, tout en soulignant les aspects qui méritent d’être améliorés. Des progrès pourront en effet être accomplis grâce aux échanges d’informations et, pour certains pays, en tirant profit de l’expérience acquise dans des pays voisins. La plupart des programmes de dépistage mis en place dans l’Europe « géographique » au cours de cette période ont gagné en maturité en termes méthodologiques (modernisation des techniques) et en termes quantitatifs (augmentation du nombre des maladies dépistées). Ces développements nous montrent que la collaboration entre les différentes organisations s’accélère en Europe. Ce n’est qu’en travaillant ensemble que nous pourrons identifier en temps opportun les nouveau-nés atteints d’une des nombreuses maladies rares détectables et prendre les mesures qui s’imposent.
Le dépistage de la phénylcétonurie en France
Authors: Wiedemann Arnaud , Jeannesson Élise , Oussalah Abderrahim , Guéant Jean-Louis , Guéant-Rodriguez Rosa-Maria , Feillet François
Published: May 2021

La phénylcétonurie (PCU) est la plus fréquente des erreurs innées du métabolisme et entraîne un retard mental irréversible en l’absence de traitement. Son dépistage néonatal a été rendu possible grâce à la technique de recueil de sang sur papier buvard mise au point par Robert Guthrie. Le dépistage néonatal de la PCU a débuté en France au début des années 1970. Il a été initialement réalisé par une technique bactériologique, puis fluorimétrique et, enfin, depuis 2020 par spectrométrie de masse en tandem. Plus de 35 millions de nouveau-nés ont été dépistés à ce jour, ce qui a permis de diagnostiquer plus de 3 500 enfants porteurs de PCU ou hyperphénylalaninémie modérée. La prise en charge de ces enfants a évolué avec le temps, en particulier grâce aux techniques de biochimie et de génétique moléculaire qui permettent un diagnostic précis et grâce à l’arrivée d’un traitement médicamenteux par saproptérine. Grâce à ce dépistage, qui permet une prise en charge précoce, le pronostic de la PCU a été transformé et, même s’il peut survenir des problèmes neurologiques ou comportementaux, ces patients ont une vie normale aujourd’hui.
Le dépistage néonatal de la surdité
Authors: Denoyelle Françoise , Rouillon Isabelle , Alvin Fiona , Parodi Marine , Couloigner Vincent , Loundon Natalie , Garabédian Noël
Published: May 2021

Le dépistage néonatal de la surdité doit être systématiquement proposé aux familles en maternité depuis l’arrêté du 23 avril 2012. La justification de ce dépistage repose sur une prévalence élevée de la surdité (autour de 1/1 000), l’existence de tests de dépistage fiables que sont les oto-émissions acoustiques et les potentiels évoqués auditifs automatisés, l’existence d’un retard important au diagnostic en l’absence de dépistage, et le bénéfice prouvé d’une prise en charge précoce. Le dépistage néonatal de la surdité permet également un bilan étiologique précoce. L’organisation actuelle de ce dépistage repose sur les Agences régionales de santé, qui s’appuient, selon les régions, sur les réseaux de périnatalité ou les centres régionaux de dépistage néonatal. La formation du personnel de maternité concerne le circuit du dépistage néonatal, l’utilisation des appareils et l’information aux familles. Le discours doit être standardisé : il s’agit de réaliser des tests d’audition, qui peuvent ne pas être concluants et sont alors répétés le lendemain ; si besoin, on revérifiera l’audition après la sortie de la maternité. En aucun cas, un diagnostic de surdité ne doit être évoqué en maternité. En cas de test anormal, une étape de re-test est prévue dans le premier mois après la naissance, avant d’adresser l’enfant dans un centre de diagnostic et de prise en charge de la surdité, où l’annonce diagnostique et la prise en charge sont multidisciplinaires. L’organisation régionale du dépistage néonatal de la surdité a conduit à une hétérogénéité des organisations et à l’absence de données nationales annuelles. Une enquête de 2015 (Santé publique France) a montré que plus de 94 % des nouveaux nés sont dépistés, avec un taux de surdité de 0,9 pour 1 000.
Global economic transformation in modern conditions: problems and challenges
Authors: Murtazova Kheda , Ibragimova Kisa
Published: May 2021

The development of the global economy has led to the fact that humanity has repeatedly faced complex problems that have a significant impact on the mechanism of the world economy. These problems fully manifested themselves in the 60-70s of the XX century and were called global. The development of the modern global economy makes adjustments to the priority of global problems. At the same time, the set of global problems is constantly changing. Old global problems acquire new content and understanding, along with the emergence of completely new global problems. The limited financial capacity of mankind to solve global problems requires political solutions and the establishment of effective international cooperation.
Analysis of the Russian finance connectivity
Authors: Smirnov Valery , Osipov Denis , Gurdzhiyan Vladimir , Soshko Irina , Alexandrov Mikhail , Ivanov Vladimir
Published: May 2021

As a result of evaluation of growth rates of major commodity prices and Russian share quotes there is discovered dominating dynamics of shares of Rosneft and Urals oil futures. Assessment of dynamics of RTSI, IMOEX, S&P500, WTI futures, USD/RUB showed IMOEX breakdown from RTSI. RTSI remained with the WTI futures, while IMOEX joined S&P500 trend. As a result of neural network analysis of importance of global indices growth rates there is determined a condition of achievement of their maximum value – minimum growth rate of RTSI and maximum rate of FTSE100 growth. Cluster analysis of the global indices in terms of their growth rates revealed connectivity between RTSI, DJIA and US Dollar Index. Russian economy structure can’t ensure direct connectivity of RTSI and DJIA. RTSI is indirectly connected to DJIA via S&P500. The leading role in this connection belongs to US Dollar Index that largely determines the dynamics of USD/RUB and IMOEX. Cluster analysis in terms of major currencies exchange rates growth defined a USD and CNY currency basket that is acceptable for the Russian economy. Analysis of the Russian finance connectivity has sufficiently identified a basis and conditions of its existence in the context of the strengthening negative factors which bind and overburden the Russian economy with oil dependence.
Digital transformation of the customer interaction system in the business model of the organization based on the omnichannel approach
Authors: Nigay Evgeniya , Lebedinskaya Yuliya , Koshevaya Elena
Published: May 2021

Maintaining a competitive position in the market in the context of digitalization becomes difficult or impossible without creating new sources of competitive advantage. The digitalization of the economy and business requires a corresponding change in the business model of the organization. One of the most urgent areas of enhancement in the structure of the business model is the system of interaction with the client. Its timely transformation provides an integrated system approach to service and customer interaction based on an omnichannel approach using a balanced and multifunctional system of digital and traditional communication channels. The article proposes the author’s approach to transforming the system of interaction with a client (through the “omnichannel prism”) in the context of the digitalization of the economy and business, defines the requirements for a business model and developed a system of indicators for assessing its efficiency.
System analysis and the problem field of digitalization in the system of the agro-industrial complex
Authors: Rasputina Alla
Published: May 2021

In the context of a global market, the agro-industrial complex (AIC) system is undergoing continuous modernization in order to respond effectively to market challenges. The project of digitalization of agriculture has a clear character of modernization. It can be assumed that this project of the Ministry of agriculture is based on an optimistic scenario (unconditional implementation of the presented quantitative indicators within the specified time frame).

The purpose of the study is to evaluate the efficiency of applying expert assessment methods to the problem of digitalization in the agro-industrial complex system. Using the methods of system analysis and, first of all, various methods of expert assessment, cognitive analysis and modeling, as well as scenario development, the weak points of the optimistic scenario of the departmental project were identified and the algorithms of the realistic scenario were determined. A review of scientific publications that reflect the problems of digitalization of agriculture, based mainly on the positions of system analysis. It is based on scientific publications in journals included in the Russian science citation index system, as well as in journals included in international scientometric databases, such as Scopus and Web of Science. The author presents the structure of problems in tabular and graphical form using methods of cognitive analysis and hierarchy analysis. The result was shown two schemes that reflect the structure of socioeconomic, technological and reengineering blocks in the agricultural sector, de-fining the basic contours of the problem field of digitization, as well as the graph structure of the problem field of digitalization of agriculture, showing the interconnection and interaction of individual structural components.
Calculation of the resource use limiting factors in the management digital transformation context
Authors: Milekhina Olga , Aslanova Irina
Published: May 2021

On the basis of the equation of entropy-information balance, which can describe the macromodel of control of equipment operation, consumption of materials, energy carriers, the limiting values of the coefficients of their use and losses are obtained. It turned out that the ratio of the latter satisfies with high accuracy the proportions of the golden section. This quantitative regularity, which is of a systemic nature, should be taken into account as a standard in the feasibility study of projects of information systems for production management, which has a probabilistic nature.
Approaches from a regional perspective of the insurance evolution in Romania - digitization of viable solution for the development of this sector during the pandemic
Authors: Ciurea Maria
Published: May 2021

Romania’s regional policy encourages the harmonious development of the territory, allowing all regions to fully capitalize on their advantages and opportunities in their economic and social development, whose main objective is to reduce disparities between regions and ensure a balanced level of development. Through this study, a synthesized analysis is performed on the evolution of the Romanian insurance market in terms of gross written premiums from general and life insurance by development regions and where the important contribution of this sector to the growth of GDP The main finding highlights the fact that the development region Bucharest - Ilfov, holds over 44% of the regional insurance market and has a substantial contribution to economic growth. At the same time, aspects of digitalization perceived as a viable solution for the dynamics of this sector during the current pandemic are also targeted.
Integration of the controlling mechanism into the Deming-Shewhart PDСA cycle in the context of digitalization
Authors: Kalemulloev Munir , Platov Alexey , Silaeva Anna
Published: May 2021

Digitalization provides an increase in the efficiency of production management, and also opens up wide opportunities for the formation of models of management decisions using predictive technologies. Digital technologies systematize and combine information flows of different origins. Thus, a predictive model of strategic and tactical production management is created. A condition for the successful digital transformation of economic sectors is the development of a set of measures for the technical re-equipment of enterprises. This article proposes an integrated controlling model based on the concept of continuous improvement of PDCA processes. The PDCA cycle model is adapted to the process of technical re-equipment of the enterprise and is integrated with the controlling mechanism based on the process approach. Such integration will ensure an increase in the controllability of the technical re-equipment process, improve the coordination of personnel actions, and create effective feedback mechanisms. The proposed model will increase the validity and efficiency of management decisions.
Real law of virtual worlds: russian approach to regulating contractual relations between a player and an operator of multiplayer online game
Authors: Turitsyn Dmitry
Published: May 2021

The widespread dissemination of Massively Multiplayer Online (MMO) games causes new problems not only in the technical field, but also in the field of law. A number of countries have successfully implemented provisions in their legislation governing the legal relationship between players and distributors of online games. However, most states have left this question unresolved. Based on the real cases, this article examines the judicial practice of resolving disputes between players and operators of MMO games in the Russian Federation. The author shows a real picture of the current state of contract law governing relations in the field of the gaming industry and the position of courts in this matter. It substantiated the conclusion on the duality of approaches to solving the question of the nature of contractual relations depending on the subject going to court in Russia. It shows the imperfection of Russian civil law in this area.
Civil proceedings with foreign participants in china - from the perspective of digital technology
Authors: Rusakova Ekaterina , Wei Wang
Published: May 2021

This article takes the legal rules of digital civil proceedings with foreign participants in China as the research object, and studies the structure and content of the civil digital litigation rule system from the present situation of the foreign-related civil digital litigation rules. The purpose of this article is to study how China constructs the foreign-related civil litigation legal system under the Internet thinking, and how to establish a digital judicial system centred on the litigants. This article discusses from two aspects: the use of digital technology to promote the settlement of foreign-related civil litigation cases, and the characteristics of new foreign-related civil litigation cases produced by digital technology.
Electronic document management and electronic cases in Russian arbitration courts: advantages and development prospects
Authors: Korobeinikova Tatiana
Published: May 2021

An analysis of the activities of arbitration courts demonstrates the effectiveness of the implementation of electronic justice in Russia, which ensures the promptness of procedural actions by the parties to the dispute. Statistics show a constant increase in the number of lawsuits filed with the courts. The current procedural legislation provides for the possibility of filing a lawsuit in court in an electronic form. Meanwhile the bulk of appeals is carried out in the usual manner in a paper form, which entails certain problems, for example, an increase in the workload on the staff of the court apparatus, the need to form court cases in a paper form, and difficulties in storage.The author proposes to establish in the law a rule providing for filing a claim in an electronic form - as the main method, and going to court by filing in a standard paper form as an exception. The implementation of this proposal will make it possible to switch to the formation of completely electronic court cases, which fully meets modern requirements. At the same time the author points to the possibility of endowing multifunctional centers for the provision of state and municipal services with the right to file lawsuits and other documents to the courts in an electronic form. This will shorten the time for consideration of cases, as well as reduce the costs of both the courts and the participants in the trial.
IT outsourcing development trends
Authors: Fedorova Svetlana
Published: May 2021

IT outsourcing is one of the new types of outsourcing. One of the current trends is the use of IT instead of other types of outsourcing. IT outsourcing implies the maintenance of the entire information infrastructure of a company (or individual components) by a third-party company, which specializes in these processes. This is a refusal to hire information technology specialists. There is no universal classification of IT outsourcing services. Several types of IT outsourcing can be distinguished: external and internal; resource and functional; outsourcing of IT infrastructure, IT processes or full outsourcing; disposable and long-term; main and additional. The IT outsourcing has a number of advantages: financial savings, the ability to engage in specialized activities, professional services, promptness of implementation of new technologies. IT outsourcing has some disadvantages: data security, trade secrets, and poor-quality services. Before using IT outsourcing services, a company should analyze business processes, determine the economic efficiency, and conclude a contract.
Assessment of the early level of distance education effectiveness
Authors: Melnikova Kseniya , Tyukina Lyudmila , Babayan Vladimir
Published: May 2021

Nowadays digital education is the one of the main parts of our life. The pandemic situation influenced greatly on digitalization of Russian higher education. Some of higher educational institutions weren’t ready for digital educational activity. This paper concerns the problem of the start of the implementation of digital education at Higher Educational Institutions. The aim of the study is to assess the efficiency of digital education at YSTU in period of the beginning of distance learning. The survey of students revealed in May, 2020, along with the defining of different types of training and the attempts to describe the factors effect on the results of the study. As a methodology we used quantitative research methods, namely, anonymous questionnaires of 204 students of the 1st and 2nd years of YSTU. The survey was conducted one month after the start of distance learning. The results can be used for statistical analysis carried out within the framework of the education reform.
University studies after the pandemic. Challenges and solutions
Authors: Akhmetova Svetlana , Nevskaya Larisa , Esaulova Irena
Published: May 2021

The transition of higher education institutions to a distance format during the pandemic has become the most discussed topic in the teaching community. As a result of the pandemic, all Russian universities found themselves in a situation where the educational process and its management were switched to a remote format all at once. This transition has accelerated the development of the digital infrastructure of universities and the inclusion of all faculty and students in the online educational environment. The Coronavirus pandemic has highlighted that, following a gradual return to a traditional form of learning, the learning strategy and resources used must change. The new environment will require new skills from teachers and students and thus changes in learning technology. New learning areas include digital tools skills, team (group) working skills in a digital environment, and skills for sharing synchronous and asynchronous formats. The article presents an analysis of the implementation of new approaches to learning during the pandemic and the prerequisites for their use after returning to the traditional form of the learning process. An analysis of attitudes of teachers and students of Perm National Research Polytechnic University towards using new tools and technologies for sustainable development of the educational process is presented. Based on the analysis, barriers to implementing the new approach are identified, and recommendations for overcoming them are offered.
Distance learning of primary school students in the assessment of parents
Authors: Proshkova Zoya
Published: May 2021

This article presents the results of a survey of parents about distance learning of their children, primary school children, during quarantine. In a sociological study, interviews were conducted with families of third grade students from St. Petersburg schools. The answers to the questions were processed using the Russian computer program “Discant”. As a result of the analysis, six leading thematic leitmotifs for a story about a new educational experience were identified. It was found that the main disadvantages of distance learning are considered by the parents to be the load on the schoolchild’s family, the large expenditure of time, and the discrepancy between teaching methods and the child’s age. According to parents, the advantages of distance education are safety, comfortable schedule, digital educational technologies. Conclusions of the project are the preference of a mixed format for teaching primary school children during quarantine. An empirical research perspective analyzes parental investment in children’s education.
Digital quality: from necessity to opportunity
Authors: Shcherbakova Ludmila , Zobova Ludmila , Evdokimova Elena
Published: May 2021

The article substantiates the systemic quality of digital society as an internal need for digital equality. The basis of the proof is the analysis of new properties of modern information: accessibility (spatial distribution and affordability) and dynamism (increase of its quantity and quality). It is shown that systematic quality is implemented through the production-technical and institutional-economic relations of the digital society thanks to the technologies of the second wave of the digital revolution: open information systems, a comprehensive Internet and big data, cloud technologies and social networks. The article presents the mechanisms changing under the influence of the system quality of the digital society: ensuring management at all levels, forming an optimal sectoral structure, identifying new sources of economic growth, changing the role of an individual in solving the problem of social development. The article summarizes that models, tasks and forms of realization of modern digital policy depend on the degree of implementation of the system quality, i.e. equality.
Agroindustrial complex system: methods of obtaining, analysis and processing of expert information
Authors: Rasputina Alla
Published: May 2021

Methods for obtaining, analyzing and processing expert information in the system of the agro-industrial complex are of great and ever increasing importance. Moreover, the subsystem of expert information is constantly evolving as a result of the qualitative growth of information and communication technologies and the improvement of the methodological and methodological apparatus of organizing and conducting examinations. Nevertheless, the potential and aggregate possible subsystems of expert information are not used effectively enough due to various reasons, both objective and subjective. The main purpose of the expert information subsystem is to organize and conduct examinations that ensure a high professional level of decision-making in the system of the agro-industrial complex at different levels of management. The research methodology is based on the selective application of system analysis methods aimed at studying complex objects and processes of the agro-industrial complex system, with the predominant use of expert assessment methods. In the process of the first stage of the study of the expert and information subsystem of the agro-industrial complex, based on the method of passive examination in the context of the agricultural digitalization project, a digraph of the structure of the problem field of digitalization was developed, which clearly reflects the interconnections and interactions of individual structural elements of the agro-industrial complex. A scheme for a multistage examination of the problem of digitalization of the regional system of the agro-industrial complex has been developed, an algorithm has been developed for the subsystem of expert information of the agro-industrial complex in the form of a tree-like digraph, reflecting the functional structure of the subsystem. This will allow in the future, with the active use of the developed algorithm for the optimal functioning of the subsystem of expert information of the agro-industrial complex, to ensure high efficiency of the decisions made and the transition to cognitive models of system control.
Influencing Factors of Cardiac Adaptation in Adolescent Athletes
Authors: Szabo Dora , Nagy Dora , Melczer Csaba , Acs Pongrac , Ratgeber Laszlo , Szokodi Istvan , Toth Miklos , Cziraki Attila , Eklics Kata , Sarszegi Zsolt
Published: May 2021

Endurance training-induced changes in left ventricular diastolic function and right ventricular parameters have been investigated extensively in adolescent athletes. Our aim was to examine the parameters for adolescent athletes (n=121, 15.1±1.6 years) compared to adult athletes and age-matched non-athletes. We explored the effects of influencing factors on the echocardiographic parameters. Significantly higher E/A (p<0.05) and e’ values (p<0.001) were detected in adolescent athletes compared to age-matched non-athletes’ and also adult athletes’ parameters. Significantly lower structural and functional right ventricular parameters (p<0.05) were detected in adult athletes. In adolescent athletes significantly higher right ventricular diameters, tricuspid S wave, right ventricular end-diastolic and end-systolic area values (p<0.05) were found compared to the matching parameters of non-athletes. We found significantly higher corrected tricuspid annular plane systolic excursion values (p<0.001) in athletes compared to the non-athletes. Based on multivariate analysis lean body mass, body surface area, age and cumulative training time were proved as strong predictive factors of both left ventricular diastolic and right ventricular parameters. Supernormal left ventricular diastolic function and significantly higher right ventricular parameters are indicative of cardiac adaptation. Well-defined cut-off values should be applied to discriminate pathological conditions in the relation of the influencing factors.
Der myofasziale Triggerpunkt – eine kritische Bestandsaufnahme
Authors: Mense Siegfried
Published: May 2021

Im ersten Teil der kritischen Bestandsaufnahme zum Thema „Myofaszialer Triggerpunkt“ (MTrP) wird der Begriff MTrP definiert, Konzepte und Prinzipien, mögliche Ursachen sowie sensible und motorische Symptome der MTrPs dargelegt und kritisch diskutiert.
Tinnitus: eine Herausforderung in der Physiotherapie
Authors: Hanskamp Miranda
Published: May 2021

Ein Tinnitus, egal ob pfeifend oder klopfend, kann die Betroffenen sehr beeinträchtigen. Physiotherapie bietet eine Möglichkeit, beeinflussende Faktoren zu finden, zu behandeln und so den Tinnitus zu verändern. Wichtig ist dafür – neben der Untersuchung von Halswirbelsäule, Kiefergelenk und Hirnnerven – herauszufinden, was der Patient selbst über den Tinnitus denkt.
Lagerung des Fußes bei Extensionstischlagerung
Authors: Motzny Alexander
Published: May 2021

Wer noch „erfolgreich“ nicht defekte Lederschuhe verwendet und keine Hygieneprobleme hat, kann diese sicher noch lange verwenden. Wer „erfolgreich“ über intakte VACOped-Schuhe verfügt und diese anwendet, kann sich freuen. Wem jedoch beides nicht zur Verfügung steht oder nicht gelingt oder wer eine Neuanschaffung plant, der sollte einmal den RotexShoe testen. Aus meiner Sicht ist das die Zukunft der Fußlagerung bei Extensionstischlagerung.
Zusammenhang zwischen eingeschränkter Hüftextension und Sitzen/Aktivitätslevel
Authors: Klien Sebastian
Published: May 2021

Boukabache A, Brookes N, Preece SJ. Prolonged Sitting and Physical Inactivity are Associated with Limited Hip Extension: a Cross-sectional Study. Musculoskelet Sci Pract 2020; 51: 102282. doi:10.1016/j.msksp.2020.102282
Tests für den M. subscapularis
Authors: Klien Sebastian
Published: May 2021

Dakkak A, Krill MK, Krill ML et al. Evidence-Based Physical Examination for the Diagnosis of Subscapularis Tears: A Systematic Review. Sports Health 2021; 13: 78–84. doi:10.1177/1941738120936232
Statt Zwang zur Impfung Vertrauen schaffen – Impfungen im Spannungsfeld zwischen Autonomie und Bevormundung
Authors: Kemper Claudia
Published: May 2021

Eine Impfung zur Pflicht zu machen, beschneidet die Autonomie der Menschen immens. Deutlich effektiver ist es, Anreize zu schaffen, meint Dr. Claudia Kemper. Die Physiotherapeutin ist überzeugt: Für die jetzige Impfkampagne im Kampf gegen COVID-19 bedarf es auf jeden Fall größerer und kreativerer Anstrengungen.
„Wir können uns nicht um Gesundheit kümmern und gleichzeitig ihre Grundlage zerstören“ – Physiotherapeut/innen für planetare Gesundheit im Gespräch
Authors: Czernik Claudia
Published: May 2021

Unter dem Bündnis Health for Future hat sich 2020 eine Unterarbeitsgruppe aus Physiotherapeut/innen gegründet. Sie loten gemeinsam aus, welchen Beitrag die Physiotherapie für den Umweltschutz leisten kann und wie die Wechselwirkungen zwischen Umweltbedingungen und Gesundheit die Therapie beeinflussen. Stellvertretend für die Gruppe hat physiopraxis mit drei Mitgliedern – Astrid Polzer, Thies Bundtzen und Michael Streicher – über Ziele und Projekte der Gruppe gesprochen.
Mit der Krankheit wachsen – Therapie bei zystischer Fibrose
Authors: Wettstein Markus
Published: May 2021

Die Diagnose zystische Fibrose begleitet Menschen ein Leben lang. In jedem Alter und jeder Lebensphase hat Physiotherapie einen hohen Stellenwert. Doch oft ist es nicht einfach, am Ball zu bleiben. Der fiktive Fall zeigt, wie wichtig es ist, Kinder und Erwachsene immer wieder zu motivieren, für sich selbst Verantwortung zu übernehmen.
Der Multiple Sclerosis Health Resource Utilization
Survey
Authors: Ness Nils-Henning , Schriefer Dirk , Haase Rocco , Ziemssen Tjalf
Published: May 2021

Hintergrund In gesundheitsökonomischen Studien sind valide und
verlässliche Kostendaten essentiell, um belastbare Schlussfolgerungen zu
ziehen und eine höchstmögliche Versorgungsqualität der
Patienten sicherzustellen. Im Falle der Multiplen Sklerose (MS) basieren solche
Studien häufig auf Primärdaten, deren zugrundeliegende
Erhebungsinstrumente nicht publiziert sind. Zudem erschweren heterogene Methoden
die Vergleichbarkeit und Interpretation solcher Studienergebnisse. Zur
Vereinheitlichung gesundheitsökonomischer Studien in der MS wurde der
Multiple Sclerosis Health Resource Utilization Survey (MS-HRS) entwickelt,
validiert und frei zugänglich publiziert.

Fragestellung Fokus dieser Übersichtsarbeit bildet der MS-HRS. Wir
berichten methodische Grundlagen zur Krankheitskostenerfassung sowie MS-HRS
basierte Ergebnisse zu den Kosten der Krankheitsdynamik bei Personen mit MS.

Material/Methodik Dieser Artikel beruht auf einer selektiven
Literaturrecherche zum MS-HRS und zu den gesundheitsökonomischen
Aspekten der Krankheitskostenerfassung.

Ergebnisse Der MS-HRS erfasst patientenberichtet die gesellschaftliche
Inanspruchnahme von direkten medizinischen, direkten nicht-medizinischen sowie
indirekten Ressourcen. Indirekte Kosten werden weiterhin zwischen Absentismus,
sowohl kurzzeitig (Krankheitstage) als auch langfristig
(Erwerbs-/Berufsunfähigkeit), und Präsentismus
unterschieden. Der Ressourcenverbrauch wird mit den gesellschaftlichen
Opportunitätskosten approximiert. Erste MS-HRS basierte Analysen zeigen,
dass neben dem stationären Behinderungsgrad und dem klinischen Verlauf
auch die Krankheitsdynamik in Form von Schüben und Progression enorme
sozioökonomische Auswirkungen hat.

Diskussion Valide Krankheitskostendaten bringen Transparenz in die
ökonomischen Auswirkungen von Erkrankungen. In Ergänzung zu
klinischen Daten kann die Kosteneffektivität festgestellt werden und
somit Anhaltspunkte für eine effizientere Patientenversorgung aufgedeckt
werden. Im Falle der MS steht zur Kostenerfassung ein frei zugängliches
Instrument (MS-HRS) zur Verfügung.
Wer macht den besseren Job? – Algorithmen vs. Experten in der Neuroreha
Authors: Mehrholz Jan , Elsner Bernhard
Published: May 2021

Es gibt immer mehr Algorithmen, die etwa Vorhersagen über die Erholung nach einem Schlaganfall treffen. Nun fragt sich, ob diese präziser sind als die Einschätzungen von Expertinnen und Experten und ob sie einen Vorteil bei der Diagnostik, Prognose und Therapie bringen. Die Professoren Bernhard Elsner und Jan Mehrholz analysieren den Status quo und geben einen Ausblick, wie Algorithmen die Neuroreha zukünftig beeinflussen könnten.
Nucleophilic H-Phosphites, H-Phosphinates, and H-Phosphine Oxides in Organic Reactions
Authors: Wang Zhan-Yong , Wang Kai-Kai , Guo Qi , Xu Shaohong
Published: May 2021

P(O)–H compounds like H-phosphites, H-phosphinates, and H-phosphine oxides are widely used as nucleophiles. Herein, their reactions with unsaturated compounds, C–H activation, the Hirao reaction, P–C, P–S, P–O, P–N, and P–F couplings are thoroughly discussed and summarized. This review will focus on their reactions with alkenes, alkynes, enamides, propynoic acids, epoxide, arynes, arenes, quinones, isothiocyanates, diazo compounds, aldehydes, ketones, imines, pyridines, acid derivatives, carbocations, aryl halides, dibromoalkenes, disulfides, thiosulfates, sulfonyl chlorides, iodonium salts, amines, alcohols, and thiols.

1 Introduction

2 Addition to Alkenes/Alkynes

3 Addition to Other Unsaturated Compounds

4 Coupling with Carbocations

5 Phosphorylation of Aryl C–H Bonds

6 Hirao Reaction

7 P–S, P–O, P–N, or P–F Coupling

8 Conclusions
Alkyl Carbagermatrane Enabled Synthesis of Seven-Membered Carbocycle-Fused Aromatics through Catellani Strategy
Authors: Xie Xiu-Ying , Jiang Wei-Tao , Xiao Bin
Published: May 2021

Synthesis of seven-membered carbocycle-fused aromatics was realized by Catellani reaction using terminally brominated alkyl carbagermatranes through intermolecular cyclization manner. Various functional groups were well tolerated, and this transformation was also expanded to the synthesis of carbocycles of other size. The utility of this method was demonstrated by modification of natural product derivatives and synthesis of bioactive molecules.