bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Coping Strategies and Medication Adherence: A Systematic Review
Authors: Chatoo Avinash , Lee SuHak
Published: October 2022

Background: Medication adherence is difficult for most patients who take at least one medication. Poor drug adherence is a developing problem since it contributes to negative outcomes, prescription waste, increased healthcare expenses, and disease progression. Coping strategies are an important tool for managing a patient's condition because a patient's coping method influences how he or she perceives the situation and deals with the stress that comes with it, which can eventually affect adherence. Coping strategies are classified into five categories: problem-focused, emotion-focused, seeking understanding, support seeking, and problem avoidance.
Objective: The goal of this study is to examine and illustrate the association of coping strategies on medication adherence.
Method: A systematic review of PubMed/MEDLINE database was conducted in order to screen and select articles. A total of 15 studies were included where they were classified by endpoints. Endpoints that were considered are medication adherence, problem-solving/active coping strategy, emotion-focused coping strategy, seeking understanding coping strategy, support seeking coping strategy and problem avoidance coping strategy. The association of each coping strategy on medication adherence was then evaluated from each article assigned to every category of coping strategies to determine if it had a favorable, negative, or no impact on medication adherence.
Results: Most studies which measured problem-solving/active coping strategy (78%) had a positive association on medication adherence, followed by studies which measured emotion-focused coping strategy (69%). Majority of the studies that evaluated for problem avoidance coping strategy (50%) showed a negative association on medication adherence and a small proportion of studies (30%) showed a positive association. Four(4) of the 5 coping strategies (problem-solving/active, emotion-focused, seeking understanding and support seeking) were found to have a greater number of studies showing positive association to medication adherence as opposed to problem avoidance.
Conclusion: The findings may suggest that problem-solving and emotion-focused coping strategies can be useful to help people with chronic conditions improve their medication adherence. More study is needed to establish a link between coping strategies and medication adherence in patients, which will allow pharmacists and other healthcare professionals to deliver better interventions to patients and assess for medication nonadherence due to poor coping skills.
Penerapan Teknik Partisi Langkah Kuda Papan Catur pada Pelabelan Super (a,d)-P_2 (▷) ̇ H-Antimagic Total Covering Sebarang Dua Graf dan Aplikasinya
Authors: Rahmatillah A H , Agustin I H , Dafik Dafik
Published: October 2022

Let  be a finite collection of simple, nontrivial and undirected graphs. A graph  is as antimagic total covering if there is bijectif  function  for every subgraph in which isomorfic to  and the total  weight,  form arithmetic sequence , in which a,b are integers and n is a number of graph cover of which the result of total comb product operation. A antimagic total covering  is as "super" if smallest label is used for vertex labelling. The way for labelling a graph this time, using a knight move partition techniques application. The graph use total comb product operation . Take a copy of  and a number  of , then put the  copy of -sequence in graph vertex  to -sequence vertex of  and put the  copy of -sequence in graft edge  to -sequence edge of  is definition of total comb product. In this article, will be investigated about Knight Move Partition Techniques Application in Labelling Super Antimagic Total Covering for Any Two Graphs and Its Application (in Constructing Ciphertext).
Investigación antropológica y compromiso político : reflexiones teórico-metodológicas sobre el trabajo de campo con organizaciones de la ciudad de Rosario (Argentina)
Authors: Cinto Agustina , Lilli Licia María
Published: October 2022

En este artículo analizamos una serie de aspectos teórico-metodológicos vinculados a la relación entre producción de conocimiento social y compromiso político, que se desprenden de la investigación antropológica junto a organizaciones. Para establecer algunas de las potencialidades y desafíos que este particular trabajo de campo implica, tomamos como punto de partida nuestros estudios doctorales en curso, financiados por el Consejo Nacional de Investigaciones Científicas y Técnicas (Conicet), que indagan en dos campos temáticos diferentes en la ciudad de Rosario (Santa Fe, Argentina).
Formas comunes y artesanales de la etnografía colaborativa
Authors: Katzer Leticia , Álvarez Veinguer Aurora
Published: October 2022

En estas páginas, ponemos en conversación dos investigaciones etnográficas colaborativas que si bien discurren en dos contextos muy diferentes confluyen en los modos, estilos y preguntas que las han guiado a nivel de texto, proceso y experiencia. Por una parte, una experiencia de una investigación junto a Stop Desahucios Granada 15M (SDG15M) (Andalucía, España) que comenzó en 2015 junto al movimiento de lucha por el derecho a la vivienda y por otro una investigación etnográfica junto a comunidades originarias y rurales del departamento de Lavalle (Mendoza, Argentina) que comenzó en el año 2004. El objetivo es detenernos en lo que consideramos, desde nuestras experiencias aterrizadas, dos hitos-dimensiones cruciales y mutuamente configuradas de las etnográficas colaborativas: la dimensión comunitaria y la dimensión artesanal. Atendiendo a esta doble dimensión, cuestionamos el estatus de «método» asignado a la etnografía ampliando así su horizonte en tanto potencial político y creativo.
Teoría crítica desde la periferia : entrevista a Eduardo Grüner
Authors: Moreno María Rita , Aguirre Aguirre Carlos
Published: October 2022

La siguiente entrevista a Eduardo Grüner se produjo en septiembre de 2019. La misma tuvo lugar en las instalaciones del Centro Científico Tecnológico Mendoza Conicet, Argentina, en ocasión del Curso de Alta Formación El arte como pensamiento crítico, dictado por el mismo Grüner y organizado por el Instituto de Ciencias Humanas, Sociales y Ambientales (Incihusa). En la entrevista se transitan diversos aspectos del pensamiento de Grüner y se procura exponer la singularidad de sus aportes a una teoría crítica gestada desde la periferia.
AKUNTANSI SEDERHANA BAGI PERUSAHAAN KECIL OLAHAN LELE ALUMNI SEKOLAH KEWIRAUSAHAAN BINA AMANAH CORDOVA
Authors: Murwaningsari Etty , Darmawati Deni , Sofie Sofie , Rachmawati Sistya
Published: October 2022

Abstrak

      Tujuan Pelaksanaan kegiatan PKM membantu pemilik usaha kecil olahan lele untuk memberikan pengetahuan dan pemahaman konsep akuntansi sederhana. Pokok bahasan dalam kegiatan PKM meliputi : 1. Pemahan siklus akuntansi 2. Pendampingan praktik klasifikasi transaksi, membuat catatan kas, membuat jurnal transaksi,3. Kegiatan PKM ini diprogramkan sebagai kegiatan yang berkelanjutan, sehingga pada akhir pendampingan diharapkan peserta akan mampu memahami tentang konsep serta mampu melakukan praktik akuntansi sederhana dalam pencatatan keuangan usahanya. Metode yang digunakan dalam pelaksanan PKM adalah penyuluhan, pelatihan dan diusulkan untuk pendampingan melalui presentasi materi oleh tim pengabdian masyarakat. Dilakukan diskusi dengan peserta dengan dipandu oleh moderator secara hybrid tatap muka langsung dan melaluli zoom. Umpan balik dilakukan dengan kuesioner.. Hasil evaluasi pelaksanaan PKM baik pada saat tatap muka dan melalui kuesioner menunjukan bahwa peserta PKM menyatakan puas dengan kegiatan, dan tujuan PKM tercapai dimana peserta merasa Akuntansi sederhana. Dan peserta PKM mampu menerapkan praktik mengklasifikasi transaksi, membuat jurnal, serta membuat catatan kas.

Kata kunci: Akuntansi Sederhana, Siklus Akuntansi, Jurnal Pencatatan, Catatan Kas
Colección Creativa: Divagaciones de la imaginación
Authors: McCorkle Lisa
Published: October 2022

This collection features three short creative writings. The first entry, “Sapos planos” (“Flat Toads”) explores the anxious memories of an adolescent that are inexorably linked to a song. On a dark night, in a subdivision that was never built, an older brother and his friend plan to teach a younger sibling how to drive by way of a gruesome game. The song “So What” by Ministry becomes the soundtrack to the youth’s foray into delinquency. The second work, “El huésped” (“The Houseguest”), is a creative continuation of the short story “El banquete” (“The Banquet”) written by Peruvian author Julio Ramón Ribeyro and published in 1958. The original story is centered on a man named Fernando who spends his fortune throwing a sumptuous party during which he asks the president of Peru to grant him several “small” favors such as naming him the ambassador to Rome. Surprisingly the president is prepared to fulfill all of Fernando’s wishes. However, during the party, some of the guests conspire to overthrow the president. The next morning, when Fernando reads the headlines about the coup d’état, he faints. This creative piece ponders what may have happened in the moments and days that followed. The final work is entitled “Mal lugar para los descalzos” (“A Bad Place for Bare Feet”) and follows a young girl’s experience at a boarding school during an unforgettable moment.
Aviso: Posibilidades de doble vida más adelante (Warning: Possibility of Double Lives Ahead) Ensayo de investigación*
Authors: McCorkle Lisa
Published: October 2022

Fictitious matriarch Morticia Addams once said, “Normal is an illusion. Normal for the spider is chaos for the fly.” In today’s society, overly simplified generalizations about a specific type of person are called “stereotypes.” They are assumptions people make about what is normal for all individuals in a perceived group. But this image is an illusion, a false caricature that must be questioned. The novel La detective miope (The Myopic Detective), written by Rosa Ribas and published in 2010, is an example of contemporary Spanish literature that challenges these preconceived notions. Ribas meticulously crafts characters that appear to fit into conventional expectations of “normal.” Yet each one hides an unforeseen side that provokes a reevaluation of concepts such as gender, occupation, and personal motives. From the secrets between a father and his daughter to the corruption of the police force and other prestigious professions- a lawyer, a bank manager, a wholesaler of fabrics, Ribas traces a parallel between these members of society and a producer of porn films, his star actress Honey Horney, and a drag queen. She challenges the reader’s assumptions about what is normal in order to make a revealing critique about the society in which these generalizations persist.
Feeding of mass fish species by natural and farmed juveniles of pacific salmons on example of the Obutonai River (Sakhalin Island)
Authors: Zelennikov O. V. , Baginsky D. V. , Sedunov P. A.
Published: October 2022

Feeding of mass fish species caught in the Obutonai River (Sakhalin, Nevelsk district) was examined in May-July 2021, in the time of downstream migration of natural pink salmon Oncorhynchus gorbuscha juveniles and release of chum salmon O. keta juveniles from a fish hatchery. Three fish species capable to predate on salmon juveniles were presented in the catches in significant number, as whitespotted char Salvelinus leucomaenis, pacific redfin Tribolodon brandtii, and juveniles and dwarf males of masu salmon O. masou. These species occurred in different lower reaches of the river. Whitespotted char fed by both pink and chum juveniles, but was relatively few in number (single mass catch). Two-year-olds and dwarf males of masu salmon fed less intensively and pacific redfin fed exceptionally rarely on the migrating pink salmon juveniles of natural origin, but both these species consumed actively the chum juveniles released from a hatchery. The masu salmon juveniles had the maximum abundance in early June, then their number decreased. The pacific redfin abundance had complicated dynamics because of migrations both from the upper part of the river and from the sea; pacific redfin spawned in late June when ate exclusively eggs of the same species.
Coho salmon Oncorhynchus kisutch (Walbaum) on the continental coast of the Okhotsk Sea
Authors: Marchenko S. L.
Published: October 2022

Coho salmon is a common object of ichthyofauna in the water bodies of the continental coast of the Okhotsk Sea, with the main stocks concentrated in the central part of the region. The species exhibits mostly the anadromous life strategy in the ontogenesis, though the resident groups are known in three lakes located in the basins of Inya, Ul’beya and Okhota Rivers. Temporal structure of anadromous coho salmon is demonstrated for the first time within the region: the stock is presented by two forms, as early and late ones. Spawning runs of these forms could be indicated by changes of qualitative parameters of fish. Coho salmon of the early and late forms reproduce on spawning grounds with different hydrological and thermal regimes. Juvenile coho salmon spend from 1 to 3 years in the fresh water before the seaward migration. Duration of marine period of their life is usually 1 year, but rarely they return for spawning either in the year of seaward migration or after two winters in the sea. Variability of abundance and qualitative parameters of coho salmon is conditioned mainly by environments of reproduction and feeding, with some impact of epigenetic difference in size and age between the life strategies in ontogenesis.
Acoustic researches of arctic cod Boreogadus saida (Gadidae) in the southwestern Chukchi Sea in 2003–2020
Authors: Kuznetsov M. Yu. , Polyanichko V. I. , Syrovatkin E. V.
Published: October 2022

Spatial distribution patterns and abundance of arctic cod Boreogadus saida are considered for the southwestern Chukchi Sea on the data of acoustic surveys and trawl samples obtained by TINRO research vessels in 2003–2020. The highest abundance and biomass of this species indicated by the echosounder–measured backscattering coefficient sA (m2 per sq.n.mile) were observed in August 2003, decreased significantly in 2007–2008 and later, with the minimum in 2010, increased in 2014 due to the high portion of juveniles, but continued to decrease in recent years and reached the lowest value in 2020. This negative tendency for arctic cod contradicts to the walleye pollock abundance increasing in the southwestern Chukchi Sea on the background of warming in the Arctic. The arctic cod were distributed mainly in the northeastern and southwestern parts of the surveyed area, usually as vast fields of small schools or sparse layers. To the east from 174°W, the aggregations were formed by large-sized fish distributed mostly at the bottom. In the western area, the aggregations were formed within thermocline at the depth of 10–20 m or had two–layer structure with the juveniles dominated in the upper layer and larger fish at the bottom. Typical echograms showed dense schools of arctic cod with the height up to 30 m and horizontal size of 120–400 m, presumably formed by migrating fish. Diurnal vertical migrations were not expressed for this species, though the aggregations of lower density were observed at night, in general, with some local aggregations of permanently dense schools, both in the daytime and at night.
Macrobenthos in the estuary of a typical «salmon» river of Sakhalin Island (on example of the Manuy River)
Authors: Labay V. S. , Korneev E. S. , Abramova E. V. , Ushakov A. A. , Akhmadeeva E. S.
Published: October 2022

Species composition, structure, density and biomass of macrobenthos in the estuary of the Manuy River are described, its main communities are defined and their trophic characteristics, production, and distribution along the river channel are determined on the materials collected in July 2021. Three main biotopic zones of the estuary are identified by their hydrological features and parameters of macrobenthos: the river mouth, the lower estuary, and the upper estuary. Bilateral structure of salinity with 0.8–5.0 psu in the upper layer and > 27 psu near the bottom was observed in the lower estuary, whereas the upper estuarine zone was filled mostly by oligohaline water (0.8–1.6 psu), with only a thin refugial layer of the seawater (23.1 psu) at the depth of 0.9 m. In total, 24 species of benthic invertebrates and cyclostomes were presented in the macrobenthos. The species richness varied insignificantly across the estuary, from 4 species/section in its upper part to 9 species/section in the lower part, with lowered richness at the border between the lower and the upper estuarine zones, that corresponded to the theory of critical salinity. The density of macrobenthos distribution decreased from the river mouth to the boundary between the lower and upper zones (from 808.0 ± 162.0 ind./m2 to 16.0±2.8 ind./m2), then increased sharply in the upper estuary (up to 1384 ± 160 ind./m2). The total biomass had two peaks: in the lower estuary (4.381 ± 0.589 g/m2) and in the upper estuary (up to 28.950 g/m2), with the minimum of 0.076 ± 0.015 g/m2 between. The boundary between the meso-, polyhaline lower estuary and the oligohaline upper estuary had the width of several hundred meters. Four benthic communities were identified by various methods of cluster and ordination analysis, regardless of the method: two communities in the upper estuary (communities of Eogammarus kygi and Neomysis awatschensis), one community in the lower estuary (community of Hediste japonica) and the community of Haustorioides at the river mouth. Gathering detritivores formed the basis of biomass and macrobenthic production at the river mouth; collecting detritophages — sestonophages were the most significant in the lower estuary; while three key trophic groups were presented in the upper estuary: 1) collecting detritivores — macrogrinders — scavengers, 2) collecting detritivores, and 3) ground feeders — collecting detritivores. Daily production of macrobenthos was low at the river mouth and in the lower part of the lower estuary but increased in its upper part and in the upper estuary.
Experiment on growing of japanese scallop Mizuhopecten yessoensis in cages in the Aniva Bay
Authors: Chernyshova Yu. S. , Prokhorova N. Yu. , Galanin D. A.
Published: October 2022

Results of experimental growing of japanese scallop Mizuhopecten yessoensis in the first three years of life in cages mounted in the Aniva Bay (southern Okhotsk Sea) are presented. Mean size and weight of the mollusks are determined and their growth rate and survival are compared with these indices for juvenile scallops from natural settlements in the Aniva Bay and other habitats located in the Far East region. Feasibility of the cage method for commercial cultivation of the scallop in conditions of the Aniva Bay is concluded.
Technological and chemical characteristics of spurdog Squalus boretzi
Authors: Shulgina L. V. , Yakush E. V. , Pavel’ К. G. , Solodova E. A. , Maltsev I. V.
Published: October 2022

Safety indices, size-weight structure, and chemical composition of the muscle tissue and liver are determined for a small-sized shark species as spurdog Squalus boretzi caught with longline in the area of Imperial Ridge seamounts (North-West Pacific). The highest catch was recorded on Koko Rise at the depth of 700 m. The sharks had the body length from 55 to 94 cm and the weight of 830–4540 g. Content of proteins and lipids in the muscle tissue (24.8 % and 0.8 %, respectively) of spurdog corresponds to low-calorie high-protein fish. The proteins contain all the essential amino acids in the ratio close to an «ideal protein». The lipids are presented by mainly phospholipids (57 % of total amount). The portion of polyunsaturated fatty acids in the lipids is 46.6 %, including 36.9 % of omega-3 fatty acids. The sum of biologically significant fatty acids (eicosapentaenoic and docosahexaenoic) reaches 34.7 %. The shark liver contains about 83 % of lipids, mostly monounsaturated fatty acids (53 % of total lipid amount) and 20.6 % of PUFA. The amount of biologically significant fatty acids (EPA + DHA) in the liver is about 10.5 %. In terms of hygienic and microbiological parameters, the muscle tissue of Squalus boretzi meets the requirements of Euro-Asian Union (№ 040/2016) and Customs Union (№ 021/2011). However, a heightened content of mercury is found in the liver of spurdog that makes difficult to use this source of valuable lipids.
Results of implementation of the concept for development of fisheries in the Russian Federation until 2020
Authors: Makoedov A. N.
Published: October 2022

Results of implementation of the Concept for development of fisheries in the Russian Federation until 2020 are considered. Of the 16 tasks, 3 (19 %) were fully implemented, 7 (44 %) were partially implemented, and 6 (37 %) were not implemented.
The Mechanistic Basis for the Oxoammonium Salt Mediated Tertiary Alcohol Oxidative Transformation Decoded by Computations: Oxoammonium Cation Acts as a Masked Carbocation, and the Previously Believed Addition Mechanism is Ruled Out
Authors: Ma Yumiao
Published: October 2022

Oxoammonium salts have been shown to be superior reagents to mediate various reactions of tertiary alcohols, including eliminative functionalization of tertiary benzylic alcohols, oxidative rearrangement of tertiary allylic alcohols, and oxidative Nazarov cyclization. These reactions have been believed to be triggered by the addition of alcohols to the N–O double bonds of the oxoammonium cation for a long time. In this work, however, combined density functional theory (DFT) and ab-initio molecular dynamics (AIMD) results show that the formation of this adduct is thermodynamically highly disfavored. Instead, through a thorough enumeration of possible mechanisms, it has been shown that the reaction occurs through a surprising ring-opening of oxoammonium cation. Oxoammonium cation acts as a masked tertiary carbocation, which triggers all the following reactions.
Polyethylene glycol-b-polylactic acid polymersome elongation through osmotic pressure mediated membrane tension and fusion
Authors: Tabah Owen , Pierce Christopher , Larsen Jessica
Published: October 2022

Polyethylene glycol-b-polylactic acid (PEGPLA) polymersomes elongate under osmotic pressure. Hypertonic NaCl solutions statistically increased the zeta potential from negative to neutral. Change in charge and PLA hydrophilicity allow for binding of polymersomes depots to increase membrane surface area. PEGPLA polymersomes exhibit biomimicry in their homeostatic responses to increased osmotic pressure.
Investigation of Structure, Ionic Conductivity and Electrochemical Stability of Halogen-substitution in solid-state ion conductor Li3YBrxCl6-x
Authors: van der Maas Eveline , Zhao Wenxuan , Zheng Zhu , Famprikis Theodosios , Thijs Michel , Parnell Steven , Ganapathy Swapna , Wagemaker Marnix
Published: October 2022

The materials Li3YX6 (X = Cl, Br) are Li-ion conductors to be used as solid electrolytes in all solid-state batteries. Solid electrolytes ideally have high ionic conductivity and (electro)chemical compatibility with the electrodes. It was proven that introducing Br to Li3YCl6 increases ionic conductivity, but, according to thermodynamic calculations, should also reduce oxidative stability. In this paper, the trade-off between ionic conductivity and electrochemical stability in Li3YBrxCl6-x (x = 0 – 6) is investigated. The results show that, while Br-rich materials are more conductive (5.36 10-3 S/cm at 30°C for x = 4.5), the oxidative stability is lower (3V compared to 3.5V). Small Br content (x = 1.5) doesn’t affect oxidative stability but substantially increases ionic conductivity compared to pristine Li3YCl6 (2.1 compared to 0.049 10-3 S/cm at 30°C). This work highlights that optimization of substitutions in the anion-framework provide prolific and rational avenues for tailoring the properties of solid electrolytes.
Photocatalytic Deoxygenative Alkylation of C(sp3)−H Bonds Using Sulfonylhydrazones
Authors: Pulcinella Antonio , Bonciolini Stefano , Lukas Florian , Sorato Andrea , Noel Timothy
Published: October 2022

The ability to construct C(sp3)–C(sp3) bonds from easily accessible reagents is a crucial, yet challenging endeavor for synthetic organic chemists. Herein, we report the realization of such a cross-coupling reaction, which combines N-sulfonyl hydrazones and C(sp3)–H donors through a diarylketone-enabled photocatalytic Hydrogen Atom Transfer and a subsequent fragmentation of the obtained alkylated hydrazide. This mild and metal-free protocol was employed to prepare a wide array of alkyl-alkyl cross-coupled products and is tolerant of a variety of functional groups. The application of this chemistry further provides a preparatively useful route to various medicinally-relevant compounds, such as homobenzylic ethers, aryl ethyl amines, β-amino acids and other moieties which are commonly encountered in approved pharmaceuticals, agrochemicals and natural products.
Flexible Screen-printed MWCNT-based Electrodes
Authors: Şen Mustafa
Published: October 2022

In this study, a stable, flexible, cheap and disposable multiwalled carbon nano tubes (MWCNT)-based screen-printed carbon electrode was developed for fast and sensitive sensor applications. A novel ink was prepared by mixing MWCNT, varnish and liquid paraffin in certain ratios. The ink was then was transferred to an acetate paper using a stencil pattern which had a working, an auxiliary and a reference electrode in its design. Commercial silver paste was used to pattern the reference electrode using the same stencil. First, the ink composition was optimizes and then the electrodes were characterized based on physical stress and electrochemical behavior at different scan rates. According to the results, the flexible electrode exhibited an excellent electrochemical behavior and expected to contribute to wearable biosensor applications due to its stability, sensitivity and flexible structure.
Electrokinetic Enrichment and Label-Free Electrochemical Detection of Nucleic Acids by Conduction of Ions Along the Surface of Bioconjugated Beads for Point-of-Care Testing
Authors: Berzina Beatrise , Peramune Umesha , Claus Echo , Kim Sungu , Saurabh Kumar , Strait Madison , Ganapathysubramanian Baskar , Anand Robbyn
Published: October 2022

In this paper, we report a method to integrate electrokinetic pre-enrichment of nucleic acids within a bed of probe-modified microbeads with their label-free electrochemical detection. In this detection scheme, hybridization of locally enriched target nucleic acids to the beads modulates the conduction of ions along the bead surfaces. This is a fundamental advancement in that this mechanism is similar to that observed in nanopore sensors, yet occurs in a bed of microbeads with microscale interstices. In application, this approach has several distinct advantages. First, electrokinetic enrichment requires only a simple DC power supply, and in combination with non-optical detection, makes this method amenable to point-of-care application. Second, the sensor is easy to fabricate, comprised of a packed bed of commercially-available microbeads, which can be readily modified with a wide range of probe types, thereby making this a versatile platform. Finally, the sensor is highly sensitive (picomolar) despite the modest 100-fold pre-enrichment we employ here by faradaic ion concentration polarization (fICP). Further gains are anticipated under conditions for fICP focusing that are known to yield higher enrichment factors (up to 100,000-fold enrichment). Here, we demonstrate detection of 3.7 pM single-stranded DNA complementary to the bead-bound oligoprobe, following a 30-min single step of enrichment and hybridization. Our results indicate that a shift in the slope of a current-voltage curve (CVC) occurs upon hybridization, and that this shift is proportional to the logarithm of the concentration of target DNA. Finally, we investigate the proposed mechanism of sensing by developing a numerical simulation that shows an increase in ion flux through the bed of insulating beads given changes in surface charge and zeta potential consistent with our experimental conditions.
Antiaromatic Covalent Organic Frameworks Based on Dibenzopentalenes
Authors: Sprachmann Josefine , Wachsmuth Tommy , Bhosale Manik , Burmeister David , Smales Glen Jacob , Kochovski Zdravko , Grabicki Niklas , Esser Birgit , Dumele Oliver
Published: October 2022

Despite their inherent instability, 4n pi-systems have recently received significant attention due to their unique optical and electronic properties. In dibenzopentalene, benzanellation stabilizes the highly antiaromatic pentalene core, without compromising its amphoteric redox behavior or small HOMO–LUMO energy gap. However, incorporating such molecules in organic devices as discrete small molecules or ill-defined amorphous polymers can limit the performance (e.g. due to solubility in the electrolyte solution or low internal surface area). Covalent organic frameworks, on the contrary, are highly ordered, porous, and crystalline materials that can provide a platform to align molecules with specific properties in a well-defined, ordered environment. We synthesized the first antiaromatic framework materials and obtained a series of three highly crystalline and porous covalent organic frameworks based on dibenzopentalene. Potential applications of such antiaromatic bulk materials were explored: COF films show a conductivity of 4 × 10^(−8) S cm^(−1) upon doping and exhibit photoconductivity upon irradiation with visible light. Investigations as battery electrode materials demonstrate their ambipolar nature and the ability to store both anions and Li ions with enhanced charge storage capabilities compared to an aromatic COF or the conductive carbon material. This work showcases antiaromaticity as a new design principle for functional framework materials.
A substructure-aware loss for feature attribution in drug discovery
Authors: Amara Kenza , Rodriguez-Perez Raquel , Jiménez Luna José
Published: October 2022

Explainable machine learning is increasingly used in drug discovery to help rationalize compound property predictions. Feature attribution techniques are popular choices within this toolbox that aim to identify which substructures of a molecule are responsible for a predicted property change. However, established molecular feature attribution methods have so far displayed low performance for popular deep learning algorithms such as graph neural networks (GNNs), particularly when compared with simpler modeling alternatives such as random forests coupled with atom masking. To mitigate this problem, in this work we present a modification to the regression objective of GNNs to specifically account for common core structures between pairs of molecules. The proposed approach shows higher accuracy on a recently-proposed explainability benchmark. We expect this methodology to be useful in drug discovery pipelines, and specifically in lead optimization efforts where specific chemical series of related compounds are investigated.
The conformational behavior and structure of monosubstituted 1,3,5-trisilacyclohexanes. Part III: 1-Methyl-1,3,5-trisilacyclohexane
Authors: Kuzmina Liubov , Arnason Ingvar , Jonsdottir Nanna , Shlykov Sergey
Published: October 2022

1-Methyl-1,3,5-trisilacyclohexane was synthesized and its structure and conformational properties have been determined by gas electron diffraction (GED) and quantum chemical (QC) calculations. The molecule may exist in two forms differing from each other by the substituents' position. QC results shows that the equatorial conformer is predicted to be slightly more stable than the axial conformer, note that one method (M06-2X) with basis set 6-311G** shows an equal amount of Ax and Eq conformers: ratio (Ax/Eq) = (30-50) : (70-50)% (depending on method and basis set). From the GED data, the molar fractions of the conformers were found to be Ax:Eq=54(10):46(10) at 280(5) K. A temperature-dependent Raman experiment resulted in an Ax:Eq ratio of 58(4):42(4). Conformational properties are compared in series of analogous 1-X-1- (hetero)cyclohexanes.
"Contacted" vs "separated" aluminyls: Dynamic alkali metal effects in H2 activation
Authors: Videa Hellen , Martinez-Martinez Antonio J.
Published: October 2022

This work discloses an unprecedented dynamic ion-pairing behaviour of "naked" aluminyl anions related to their stability and reactivity in solution. Rapid exchange between charge-separated and contacted species of the aluminyl anion [(BDI’)AlI]– (BDI’ = H2C=C(NAr)-C(H)=C(Me)-NAr; Ar = 2,6-iPr2C6H3) occurs in solution with [(L)M]+ counterions (M = Cs, K). While the two-dimensional polyether 18-crown-6 (L) favours the formation of persistent contacted species, the three-dimensional 2.2.2-cryptand ligand allows facile exchange. These aluminyl processes are experimentally probed by NMR spectroscopy, including DOSY NMR, and X-ray crystallography, which provide intimate details of the ion-pairing reversibility and ionic separations. The lability in these aluminyls is important for their stability and reactivity with the non-polar H2.
Cobalt(II) Alginate as a Precursor for Green Synthesis of Cobalt Oxide Nanoparticles
Authors: Orhan Burcu , Adetoro Titilayomi Roseline , Kaygusuz Hakan
Published: October 2022

There is an increasing scientific interest in environmentally friendly methods in nanoparticle synthesis. In this study, cobalt oxide nanoparticles were prepared by thermal decomposition of cobalt crosslinked alginate gel, where alginate acts as a precursor. The resulting material was characterised using X-ray diffraction (XRD). The size of nanocrystals was 32 nm as calculated by the Scherrer equation and the size of nanocrystals varied between 1 and 60 nm according to grain size distribution (GSD). Transmission electron microscopy (TEM) was used to observe nanocrystals. Thermogravimetric analysis (TGA) was studied to elucidate the formation of cobalt oxides from cobalt crosslinked alginate beads. An easy and cost-effective method was reported for the synthesis of Co3O4 nanoparticles.
Innovative Model of Vocational Cooperation of Stakeholders in the Nuclear Industry on the Basis of Volgodonsk Engineering Technical Institute the Branch of National Research Nuclear University «MEPhI»
Authors: Rudenko V. A. , Tomilin S. A. , Zheleznyakova A. V. , Lobkovskaya N. I.
Published: October 2022

The paper provides an overview of career guidance cooperation possibilities between the stakeholders of the educational process and nuclear industry specialists in order to deepen the integration of the school, the technical university and production. A model of collaboration of the main stakeholders to build an effective system of social partnership in the field of vocational education and improve the quality of graduate training for the nuclear industry is proposed.
Case for investment in tobacco cessation: a population-based analysis in low- and middle-income countries
Authors: Sandoval Guillermo A. , Totanes Robert , David Annette M. , Fu Dongbo , Bettcher Douglas , Prasad Vinayak , Arnold Virginia
Published: October 2022

This study aimed to estimate the return on investments of three population-level tobacco cessation strategies and three pharmacological interventions. The analysis included 124 low- and middle-income countries, and assumed a 10-year investment period (2021–2030). The results indicate that all six cessation programmes could help about 152 million tobacco users quit and save 2.7 million lives during 2021–2030. If quitters were followed until 65 years of age, 16 million lives could be saved from quitting. The combined investment cost was estimated at 1.68 United States dollars (US$) per capita a year, or US$ 115 billion over the period 2021–2030, with Caribbean countries showing the lowest investment cost at US$ 0.50 per capita a year. Return on investments was estimated at 0.79 (at the end of 2030) and 7.50 if benefits were assessed by the time quitters reach the age of 65 years. Disaggregated results by country income level and region also showed a return on investments less than 1.0 in the short term and greater than 1.0 in the medium-to-long term. In all countries, population-level interventions were less expensive and yielded a return on investments greater than 1.0 in the short and long term, with investment cost estimated at US$ 0.21 per capita a year, or US$ 14.3 billion over 2021–2030. Pharmacological interventions were more expensive and became cost beneficial over a longer time. These results are likely conservative and provide support for a phased approach implementing population-level strategies first, where most countries would reach break-even before 2030.
Pengembangan Media Pembelajaran Akuntansi Berbasis Android “LAKEUN” Pada Materi Laporan Keuangan Perusahaan Dagang Kelas XI Akuntansi SMKN 6 Surabaya
Authors: Zaman Achmad Qomaruz , Listiadi Agung
Published: October 2022

The development of science and technology has an impact on teaching and learning activities. Educators are required to make teaching and learning activities more varied so that students can play an active role during teaching and learning activities. Learning media can be an alternative for educators to create student participation during teaching and learning activities. Based on observations made by researchers, it was found that the media that had been used by accounting teachers at SMKN 6 Surabaya, especially in the accounting department, still depended on power points and lacked use of developed technology. This study has a goal to create an android-based accounting learning media for students of class XI Accounting at SMKN 6 Surabaya and see how feasible Android-based accounting learning media is as a creative medium in the accounting practicum learning process for service, trade, and manufacturing companies. In developing learning media using the 4D model by Thiagarajan which consists of the definition stage (Define), the design stage (Design), the development stage (Develop), and the dissemination stage (Disseminate). Data collection techniques were in the form of validation questionnaires and student response questionnaires related to the developed media. The results of the evaluation carried out by material experts and media experts, Lakeun's learning media can be said to be feasible, as well as student responses regarding the learning media made also obtain very understood criteria.
Pengaruh Motivasi, Mata Kuliah Perpajakan dan Literasi Perpajakan Terhadap Minat Mahasiswa Fakultas Ekonomika dan Bisnis Universitas Negeri Surabaya dalam Berkarir di Bidang Perpajakan
Authors: Yakin Achmad Ainul , Widayati Irin
Published: October 2022

This research was conducted to determine the effect of motivation, taxation courses and tax literacy on the interests of FEB UNESA students in careers in taxation. This research uses purposive sampling method. The research sample consisted of 100 students from the Accounting, Accounting Education, Economics Education, Office Administration and Management study programs at the State University of Surabaya who had taken the taxation course program.. The research utilizes the main data obtained through the distribution of questionnaires in a google form format with a Likert scale. Data analysis through multiple linear regression. The outputs obtained, namely Motivation (X1), Taxation Courses (X2) and Tax Literacy (X3) have a large significant effect on the interest of FEB UNESA students in determining a career in taxation.
Professional competition as a significant resource for improving pedagogical skills
Authors: Kamerilova G. S. , Prokhorova I. V.
Published: October 2022

Introduction. The subject of the study in this article is a theoretical understanding of the role of professional competitions to ensure the safety of children on the roads in the development of pedagogical skills of educational workers. It is argued that the competitive participation of creative teachers demonstrating the best integration practices serves as confirmation of the continuity of pedagogical education, its qualitative progress. A model of improving pedagogical skills in the field of child traffic safety based on the ideas of axiology, integration, communicativity in competitive professional activities is justified. Its leading functions and stages are defined. Scientific reasoning is based on the results of the examination of inter-subject road safety projects presented as part of the All-Russian Pedagogical Festival (Moscow, 2021), conducted by employees of the Department of Human Physiology and Life Safety of Mininsky University.

Materials and Methods. The materials were the results of an expert assessment of competitive projects (273) of interdepartmental and integrative training of children in safe behavior on the roads, carried out by teachers of 43 constituent entities of the Russian Federation. Analysis and evaluation of author's projects was carried out on the basis of a system of diagnostic methods, revealed in domestic and foreign works, and formatted within the framework of the Pedagogical Festival. The objective and objectives identified the need for analysis methods, including comparative; generalizations and systematization, forecasting and modeling.

Results of the study. Formation of a modern scientific idea of professional competitions as effective means of continuing education and substantiation of the model of improving pedagogical skills in the field of child traffic safety based on the implementation of integration projects in competitive professional activities

Discussion and Conclusions. The merits of professional competitions in the understanding by teachers of their own experience and reflection in the direction of further self-realization in the context of new educational strategies have been revealed; it was concluded that it is necessary to model the professional improvement of teachers in the training of children in road safety in the logic of integrative design activities and diverse communicativity.
Socio-psychological portrait of a modern schoolchild
Authors: Lebedeva O. V. , Povshednaya F. V.
Published: October 2022

Introduction. The relevance of studying the socio-psychological characteristics of modern children and adolescents is associated with the processes of globalization, informatization, digitalization of modern society in relation to the education system in general and the personality of a modern schoolboy in particular. In this article, an attempt is made to present a socio-psychological portrait of a modern schoolboy, to determine the role of a teacher in the digital educational environment, as well as the possibilities of his professional and personal growth in the conditions of digitalization by analyzing and systematizing the results of theoretical and experimental research on the problem.

Materials and Methods. This article uses an analytical approach to the consideration of modern domestic and foreign studies, which allows to identify the positive and negative sides of the digitalization of the modern education system. We focused on scientific articles, monographs, teaching aids, dissertation studies containing the results of theoretical and experimental studies of various aspects of this problem.

Results. As the analysis of the literature has shown, the studies of foreign authors widely cover this problem from the perspective of the "theory of generations", while domestic research is largely based on the methodology of domestic psychology. In the Russian psychological literature, a number of studies are devoted to the study of the socio-psychological characteristics of modern adolescents, in particular, the system of value orientations, attitudes to educational activities, socialization, including using social networks, adaptability to the conditions of the educational environment, but such studies are insufficient due to the complexity of the studied issues and the constantly changing conditions of the social life of a modern student.

Discussion and Conclusions. The discussion of issues related to the socio-psychological characteristics of a modern schoolboy in the conditions of digitalization of the system of national education invariably rests on the need to find forms, methods, means of organizing effective school education and assumes that teachers of the general education system have a minimum of psychological knowledge about age and individual psychological patterns of the development of the psyche of a younger schoolboy and a teenager, the formation of his personality.
Psychological mechanisms for the development of intelligence of the future officer
Authors: Naumov P. Yu.
Published: October 2022

Introduction. Solving the problems of identifying and explaining the functioning of intelligence in the structure of personality involves at least two aspects: the first is aimed at its development and functioning, the second is aimed at establishing the mechanisms for the development of intelligence, manifested in the personality-subject mental reality. The author, consistently solving the problems of analyzing the mental mechanisms of the development of intelligence, identifies those, and also comes to the conclusion about which of them performs the syncretic function and the function of integration.

Materials and Methods. To solve the problems defined in the article as the main methodology, the authors use systematic, activity-oriented, complex and axiological approaches focused on the analysis of intelligence and the features of its functioning. As the main research methods, theoretical (hypothetical-deductive method, conceptualization), general logical (analysis and synthesis, deduction and induction, comparison and analogy) and empirical (expert survey, observation, analysis of independent characteristics and results of activity) methods of scientific research are used.

Results. Applying the methodology of systematic research for a consistent theoretical analysis of the real mental properties of a person and their manifestation in activity, the author comes to the conclusion that the main psychological mechanisms for the development of the intelligence of a future officer are adaptation, cultivation, internalization, exteriorization, intellectualization, existentialization. They are closely related to the social mechanisms of the formation of subjectivity, which include socialization, education, aestheticization, creativity and inclusion in joint activities. It has been established that a syncretic function in the development of the intelligence of a future officer in the structure of the psyche is performed by the mechanism of cultivation, ensuring the unity of the functioning of these processes in the mental reality of the subject.

Discussion and Conclusions. The establishment of the mechanisms for the development of the intelligence of a future officer, their essence and structure, as well as the features of their functioning and interaction with other mental processes, allows us to comprehensively understand the process of development of the personality and subjectivity of a cadet in a military educational organization of higher education. The results of the study can be used in scientific research and in educational activities.