bluuebunny/crossref_metadata_2025 huggingface dataset:
Methodology of Management of Innovative Development of Complex Socio-Economic Systems in the Information Society
Authors: He Yong , Tsibizova Tatiana Yu. , Neusypin Konstantin A. , Selezneva Maria S.
Published: December 2020

The article presents methodological recommendations for managing the innovative development of complex socio-economic systems in the context of movement towards the information society, the formation and development of problem-oriented information and communication social spaces, the formation of specialized virtual innovation clusters, the organization of effective interaction between government bodies and local self-government, economic entities, their associations, other organizations and citizens having common interests and a common goal. The proposed methodological recommendations and model of innovative development can, with account of specific features, be effectively applied in various sectors of the national economy. Using the research results in practice will contribute to solving the problem of innovative modernization of the country, adapting authorities, organizations and citizens to the conditions of the global information society, increasing the functioning and competitiveness of complex socio-economic systems, improving quality and increasing the volume of socially significant products. An intelligent control system is proposed and a technology for managing the innovative development of complex socio-economic systems is developed.
Comparative Analysis of Disaster Management Between Indonesia and Japan from Regulatory and Institutional Aspects
Authors: Yustisia Lestari Titie , Rachman Rahmia , Septhiany Prihatiningsih Syamsuddin Adiesty
Published: December 2020

The Indonesian government still faces several obstacles in handling disasters. One classic obstacle is the implementation of disaster management regulation that is not yet optimal. Japan’s regulation on disaster management has been in existence since 1941, indicating that the readiness of the Government of Japan in tackling disasters has begun long before the Indonesian Government enacts Act No. 24 of 2007. This study uses a comparative analysis research method by comparing the regulation related to disaster prevention in Japan and Indonesia. In addition, the author also tries to make comparisons between disaster management agencies that exist in Japan and Indonesia. The results show that the readiness of the Government of Indonesia related to the regulation and institutional of disaster management has undergone significant improvement since the handling of the earthquake and tsunami that hit Aceh and Nias in 2004 ago. There are many disaster management differences between Indonesia and Japan. One of the significant ones is the alertness of the Japanese government in conducting preventive prevention through the socialization of disaster reduction that involves all elements of society.
Comparison of the input photovoltaic water pump with and without floating cooling system
Authors: Arifin Yusnaini , Sarjan Muhammad , Indrajaya Aristo
Published: December 2020

Solar water pumps are one of the solar technologies that is becoming popular to fulfil the water requirement, particularly in the areas with limited or no access to electricity. However, the voltage of photovoltaic (PV), one of solar technology, drops as the temperature rises. Therefore, efforts are required to lower the temperature in the photovoltaic. This study aimed to observe the effect of cooling PV on direct-coupled water pump, motor and pump connected directly to PV. In this study, the cooling method used is floating method. Two module of PV were used. A photovoltaic module is firmly installed on an artificial pool as a cooling PV and the other without cooling. The results showed that a cooling photovoltaic (PV) produced higher power output transferred to motor and pump and had higher efficiency. In general, the power generated during the period measurement by PV with cooling is greater than that of PV without a cooling method. At 17:00 pm, when the intensity reaches 236 W/m2, the direct-coupled water pump with cooling PV system is able to operate with 9. 9484 W of power input. Meanwhile, under the same intensity, the water pump without cooling PV come into a halt, with 8. 6597 W of the input power.
Elastic Foundation Beam Analysis on Rigid Pavement and Piles
Authors: Arifin Syamsul , Dolu Anwar , Rivani Agus
Published: December 2020

In this study, the rigid pavement structure and pile foundation were modeled as the foundation of the Winkler elastic beam. for pavement with distribution loads and traffic loads, and variations in support. While for pile foundations with lateral loads. Solution of analytical differential equations with computer applications (CAS) Maple. The aim of this research are : (a). To know whether completion of algebraic computer application can be obtained by analytically method or numerically method, (b). To check whether analytical model is possible to be applied to various loads at any point in the beam or not, (c). Where of the strength or the displacement boundary to be located in the beam during load application, (d). To verify an approach possibility implementation of a simple computer algebra system, (e). To know whether achieved solutions which possible to solve ordinary differential equation (ODE) can be implemented in any mathematical system.
Concept based on Local Wisdom of Kaili Ethnic “Tampa Nu Bau” for Disaster Mitigation of Sea Storm
Authors: Bakri Muhammad , Luthfiah  , Ahmad Kasim Anita
Published: December 2020

Sea Storm or tidal waves are one of the natural disasters that impose risks to human life. One of those potentially threatened by sea storms is fishermen who are fishing. Mitigation of sea storms is not only carried out on land but also at sea. Local wisdom has been used as an effort to mitigate disaster. This study aims to find the concept of space-based on a community’s local wisdom in disaster mitigation. Kaili tribe is one of the ethnic groups living in Sulawesi, especially in Central Sulawesi province. The proposed concept of space is “Tampa Nu Bau” concept, which in the Kaili language means a space located at sea and serves as a transit space for fishermen when fishing. The method used in this research is phenomenology. This method is done by observing the behavior of fishermen, behavior mapping, ethnic wisdom behavior and superimposition which are often shown by fishermen when using the “Tampa Nu Bau” room. The results obtained in this study are the concept of space-based on local wisdom that can reduce the risk of storm disasters in the Sea.
Soyons plus ambitieux pour traiter le suicide
Authors: Courtet Philippe , Nobile Bénédicte , Olié Émilie
Published: December 2020

Il est difficile de discuter de la mort sans parler de la mort volontaire. Le suicide est en effet un enjeu de santé publique majeur. Il est donc primordial de pouvoir identifier les sujets à risque et de les prendre en charge. Cependant, cet exercice reste complexe. Une première avancée est de considérer les conduites suicidaires (CS) comme une entité diagnostique à part entière avec sa propre physiopathologie. De nouvelles pistes de compréhension sont aussi nécessaires ; le rôle de la douleur tant physique que sociale dans le suicide est une voie prometteuse. Les traitements pharmacologiques actuels visent principalement à traiter les pathologies associées à ces conduites, mais certaines molécules ayant une action anti-suicidaire rapide et spécifique, comme la kétamine, se montrent encourageantes.
Un cadeau empoisonné
Authors: Jordan Bertrand
Published: December 2020

GWAS analysis of severe Covid patients implicates a major locus on chromosome 3. The corresponding 50 kb segment appears to originate from Neanderthal/Sapiens crossings, raising interesting evolutionary questions.
Visualizing sporadic E using aeronautical navigation signals at VHF frequencies
Authors: Hosokawa Keisuke , Kimura Kotaku , Sakai Jun , Saito Susumu , Tomizawa Ichiro , Nishioka Michi , Tsugawa Takuya , Ishii Mamoru
Published: December 2020

To understand the dynamical properties of sporadic E layer (Es), we have developed a method to visualize the two-dimensional spatial structure of Es by monitoring the occurrence of anomalous propagation of VHF waves used for aeronautical navigation systems in combination with the electron density disturbance index ROTI, that is the Rate of total electron content (TEC) Index obtained from ground-based GPS receivers. We introduce a case of strong Es layer which occurred for ~4 h during daytime of July 4, 2019. In this interval, we succeeded in imaging the structure of Es elongating more in the east–west direction and moving northward gradually. This result indicates that the combination of network observations of aeronautical navigation signals and ROTI is capable of imaging the 2D structure of Es in a wide area including the sea surface, which enables us to discuss the dynamical characteristics and generation mechanism of Es.
Recent Advancement of Synthesis of Isatins as a Versatile Pharmacophore: A review
Authors: Kumar Gajendra , Singh Netra Pal , Kumar Kaushal
Published: December 2020

Isatin (1 H-indole-2, 3-Dione) and its derivatives are versatile compounds which acts as a precursor for a large number of pharmacologically active compounds. Therefore isatins have a significant importance in the synthesis of different heterocyclic compounds. Isatins show variety of biological activities. In this review we focus on synthetic methods of isatins and their biological activities such as antimicrobial, anticonvulsant, anti-inflammatory and analgesic activity, antitubercular activity.
Iron deficiency, depression, and fatigue in inflammatory bowel diseases
Authors: König Peter , Jimenez Kristine , Saletu-Zyhlarz Gerda , Mittlböck Martina , Gasche Christoph
Published: December 2020

Background Iron deficiency and anemia are common findings in IBD. Treatment of anemia improves quality of life. Neurological symptoms like depression or anxiety are also common in IBD; however, their relationship with ID has not been studied in detail.

Methods Prospective, single center, non-interventional trial in an IBD cohort (n = 98), which is generally at risk for ID. Quality of sleep (using the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Insomnia Severity Index) and the presence of fatigue (Piper fatigue scale), depression (Self-rating Depression Scale [SDS]) or anxiety (Self-rating Anxiety Scale [SAS]) were related to ID (ferritin, transferrin saturation), anemia (hemoglobin), and inflammatory disease activity (CRP).

Results ID was present in 35 %, anemia in 16 %, and inflammation in 30 %. The overall quality of sleep in this cohort was similar to that reported for the general population. ID, anemia, or inflammation had no influence on the PSQI (median 4.0 [CI 3.0–5.0]), the ESS 5.5 (5.0–7.0), and the ISI 4.00 (2.5–5.5). Fatigue (PFS; present in 30 %), anxiety (SAS; present in 24 %), and depression (SDS; present in 33 %) were more common than in the general population. Iron deficient and anemic patients were more likely to be depressed (p = 0.02 and p < 0.01) and showed a trend towards presence of fatigue (p = 0.06 and 0.07). Systemic inflammation as measured by CRP had no effect on any of these conditions.

Conclusion In this IBD cohort, ID and anemia affect depression and possibly fatigue independent of the presence of inflammation.
A Review of the Phytochemistry, Traditional Uses and Biological Activities of the Essential Oils of Genus Teucrium
Authors: Candela Rossella Gagliano , Rosselli Sergio , Bruno Maurizio , Fontana Gianfranco
Published: December 2020

The genus Teucrium is a large and polymorphic genus of the Lamiaceae family distributed in mild climate zones, particularly in the Mediterranean basin and Central Asia. Studies of nonvolatile constituents of Teucrium species showed that they are a rich source of neo-clerodane diterpenoids, considered as chemotaxonomic markers of the genus. In addition to the nonvolatile metabolites, there has been a large interest in the essential oils of this genus. In this review, a complete survey of the chemical composition and biological properties of the essential oils isolated from Teucrium taxa is provided. In traditional medicine, since ancient times, species of this genus have been widely implemented for their biological properties, including antimicrobial, anti-inflammatory, antispasmodic, insecticidal, anti-malaria, etc. Therefore, a complete review of all of the traditional uses of Teucrium taxa are also reported.
Treatment Goals for Patients with Schizophrenia — A Narrative Review of Physician and Patient Perspectives
Authors: Gründer Gerhard , Bauknecht Philipp , Klingberg Stefan , Leopold Karolina , Paulzen Michael , Schell Stefanie , Stengler Katarina , Leucht Stefan
Published: December 2020

Introduction There are many possible treatment goals for patients with schizophrenia. Two major perspectives on treatment goals are the patient’s and the physician’s perspective. Patient-centered treatment mandates that an individual patient’s treatment goals are taken into account when treatment is planned. In this narrative review, we address the commonalities and differences of the patient’s and physician’s perspectives.

Methods We searched for literature on treatment goals for patients with schizophrenia from the last 10 years.

Results Fifty-two relevant records were identified, 4 of which directly compare patient’s and physician’s perspectives. Two further articles used the same set of goals to ask patients or physicians for their assessment.

Discussion Agreement between patients and physicians regarding valuation of treatment goals was high. However, physicians tended to put more emphasis on the classical “textbook” goals of symptom resolution and functioning, while patients stressed well-being and quality of life more. Results on treatment goals from patients are difficult to generalize, since recruiting representative patient samples is challenging and patient subgroups may have differing priorities.
Molecular Networking Discloses the Chemical Diversity of Flavonoids and Selaginellins in Selaginella convoluta
Authors: Reginaldo Fernanda Priscila Santos , Bueno Paula Carolina Pires , de Isabelly CristinaMatos Costa , de AlanAraújo Roque , Fett-Neto Arthur Germano , Cavalheiro Alberto José , Giordani Raquel Brandt
Published: December 2020

Selaginella convoluta is a desiccation tolerant plant native to the Brazilian semiarid region (Caatinga), endowed with an effective drought resistance mechanism. As part of our research efforts to understand the chemical diversity of S. convoluta, dehydrated (harvested in their natural habitat in the dry season) and hydrated (plant acclimated in a laboratory after rehydration) specimens were analyzed by HR-LC-ESI-MS/MS followed by a structural annotation on the Global Natural Products Social Molecular Networking Web platform. The molecular networking approach allowed for putative annotation of 39 metabolites, mainly selaginellins and flavonoids. Based on MS/MS data, three unprecedented selaginellins were annotated: 29-hydroxy selaginellin O, 29-hydroxy selaginellin A, and 4-{[2-(4-hydrophenyl)-6-[2-(4-hydroxyphenyl)ethynyl]phenyl](4-oxocyclohexa-2,5-dien-1-ylidene)methyl}benzaldehyde. Th results pointed out that valuable scientific knowledge can be obtained
from studies conducted with plants in their natural habitat by allowing a more realistic profile of chemical diversity. The present study adds new information on specialized metabolites of S. convoluta, mainly flavonoids and selaginellins, and highlights the species as an untapped source of chemobiodiversity from Caatinga.
Role of Bisphosphonates in The Prevention of Postoperative Hungry
Bone Syndrome in Primary Hyperparathyroidism: A Meta-Analysis and Need for
Randomized Controlled Trials
Authors: Pal Rimesh , Gautam Akanksha , Bhadada Sanjay Kumar
Published: December 2020

Dear Editor,

Hungry bone syndrome (HBS) is a clinico-biochemical entity characterized by the
development of profound and prolonged hypocalcemia associated with hypophosphatemia,
hypomagnesemia, and rising alkaline phosphatase which follows curative
parathyroidectomy for severe primary and secondary hyperparathyroidism. The
prevalence of HBS after parathyroidectomy in primary hyperparathyroidism (PHPT) is
variable with several case series from Asia reporting remarkably higher prevalence
rates of 24–87% 1.
Factors associated with complete clip closure after endoscopic mucosal resection of large colorectal polyps
Authors: Pohl Heiko , Pellisé Maria , Ortiz Oswaldo , Rex Douglas K. , Grimm Ian S. , Moyer Matthew T. , Hasan Muhammad K. , Pleskow Douglas , Elmunzer B. Joseph , Khashab Mouen A. , Sanaei Omid , Al-Kawas Firas H. , Gordon Stuart R. , Mathew Abraham , Levenick John M. , Aslanian Harry R. , Antaki Fadi , von Renteln Daniel , Crockett Seth D. , Rastogi Amit , Gill Jeffrey A. , Law Ryan , Wallace Michael B. , Elias Pooja A. , MacKenzie Todd A.
Published: December 2020

Background and study aim Delayed bleeding is a common adverse event following endoscopic mucosal resection (EMR) of large colorectal polyps. Prophylactic clip closure of the mucosal defect after EMR of nonpedunculated polyps larger than 20 mm reduces the incidence of severe delayed bleeding, especially in proximal polyps. This study aimed to evaluate factors associated with complete prophylactic clip closure of the mucosal defect after EMR of large polyps.

Methods This is a post hoc analysis of the CLIP study (NCT01936948). All patients randomized to the clip group were included. Main outcome was complete clip closure of the mucosal resection defect. The defect was considered completely closed when no remaining mucosal defect was visible and clips were less than 1 cm apart. Factors associated with complete closure were evaluated in multivariable analysis.

Results In total, 458 patients (age 65, 58 % men) with 494 large polyps were included. Complete clip closure of the resection defect was achieved for 338 polyps (68.4 %); closure was not complete for 156 (31.6 %). Factors associated with complete closure in adjusted analysis were smaller polyp size (odds ratio 1.06 for every millimeter decrease [95 % confidence interval 1.02–1.08]), good access (OR 3.58 [1.94–9.59]), complete submucosal lifting (OR 2.28 [1.36–3.90]), en bloc resection (OR 5.75 [1.48–22.39]), and serrated histology (OR 2.74 [1.35–5.56]).

Conclusions Complete clip closure was not achieved for almost one in three resected large nonpedunculated polyps. While stable access and en bloc resection facilitate clip closure, most factors associated with clip closure are not modifiable. This highlights the need for alternative closure options and measures to prevent bleeding.
Ear Parade: A Call for Preventive Actions to Strengthen the Healthcare System against Hearing Loss
Authors: Lopes Paula Tardim , Bento Ricardo Ferreira
Published: December 2020

Introduction Approximately 10 million people in Brazil have some hearing impairment. Because of the natural progression of hearing impairment to presbycusis, coupled with the increasing number of young people exposed to the risk factors for early hearing loss, the social impact of hearing impairment is high.

Objective A team of otolaryngologists and speech therapists conducted an unprecedented worldwide campaign in the primary health sector, aiming to reduce the global burden of hearing impairment with preventive measures.

Methods A cultural information campaign called “Ear Parade” was developed. It lasted 3 months, during which São Paulo received information on the prevention of deafness and the importance of hearing rehabilitation to reduce prejudice against the use of hearing aids.

Results The information was relayed through an art exhibition of public paintings, including 62 sculptures of ears, 2.40 meters high, which colored the city, elucidating the beauty of hearing. The media coverage impacted 170 million people, and at the end of the campaign, a nongovernmental organization was established to raise resources for hearing rehabilitation. In addition, an auction of the ear sculptures raised money toward hearing aid batteries and stem-cell research for hearing.

Conclusion The present paper presents the effects of this campaign. Information dissemination is a powerful preventive measure for the primary healthcare system to reduce future treatment expenditures.
Early Serum Biomarkers for Intensive Care Unit Treatment within the First 24 Hours in Patients with Intracerebral Hemorrhage
Authors: Bender Michael , Naumann Tim , Uhl Eberhard , Stein Marco
Published: December 2020

Background The prognostic significance of serum biomarkers in patients with intracerebral hemorrhage (ICH) is not well investigated concerning inhospital mortality (IHM) and cardiopulmonary events within the first 24 hours of intensive care unit (ICU) treatment. The influence of troponin I (TNI) value and cortisol value (CV) on cardiopulmonary events within the first 24 hours of ICU treatment was reported in subarachnoid hemorrhage patients, but not in ICH patients up to now. The aim of this study was to investigate the role of early serum biomarkers on IHM and TNI value and CV on cardiopulmonary events within the first 24 hours of ICU treatment.

Patients and Methods A total of 329 patients with spontaneous ICH were retrospectively analyzed. Blood samples were taken on admission to measure serum biomarkers. The TNI value and CV were defined as biomarkers for cardiopulmonary stress. Demographic data, cardiopulmonary parameters, including norepinephrine application rate (NAR) in microgram per kilogram per minute and inspiratory oxygen fraction (FiO2) within the first 24 hours, and treatment regime were analyzed concerning their impact on ICU treatment and in hospital outcome. Binary logistic analysis was used to identify independent prognostic factors for IHM.

Results Patients with initially nonelevated CVs required higher NAR (p = 0.01) and FiO2 (p = 0.046) within the first 24 hours of ICU treatment. Lower cholinesterase level (p = 0.004), higher NAR (p = 0.002), advanced age (p < 0.0001), larger ICH volume (p < 0.0001), presence of intraventricular hemorrhage (p = 0.007) and hydrocephalus (p = 0.009), raised level of C-reactive protein (p = 0.024), serum lactate (p = 0.003), and blood glucose (p = 0.05) on admission were significantly associated with IHM. In a multivariate model, age (odds ratio [OR]: 1.055; 95% confidence interval [CI]: 1.026–1.085; p < 0.0001), ICH volume (OR: 1.016; CI: 1.008–1.025; p < 0.0001), and Glasgow Coma Scale (GCS) score (OR: 0.680; CI: 0.605–0.764; p < 0.0001) on admission as well as requiring NAR (OR: 1.171; CI: 1.026–1.337; p = 0.02) and FiO2 (OR: 0.951; CI: 0.921–0.983, p = 0.003) within the first 24 hours were independent predictors of IHM.

Conclusion Higher levels of C-reactive protein, serum lactate, blood glucose, and lower cholinesterase level on admission were significantly associated with IHM. Patients with initially nonelevated CVs required higher NAR and FiO2 within the first 24 hours of ICU treatment. Furthermore, requiring an NAR > 0.5 µg/kg/min or an FiO2 > 0.21 were identified as additional independent predictors for IHM. These results could be helpful to improve ICU treatment in ICH patients.
Frequency-Following Response (FFR) in Military Pilots
Authors: Martins-Moreira Graziela Maria , Durante Alessandra Spada
Published: December 2020

Introduction Good hearing in pilots, including central auditory skills, is critical for flight safety and the prevention of aircraft accidents. Pure tone audiometry alone may not be enough to assess hearing in the members of this population who, in addition to high noise levels, routinely face speech recognition tasks in non-ideal conditions.

Objective To characterize the frequency-following response (FFR) of a group of military pilots compared with a control group.

Methods Twenty military pilots in the Study Group and 20 non-pilot military personnel, not exposed to noise in their work, in the Control Group, all with normal hearing, aged between 30 and 40 years old, completed a questionnaire to assess their hearing habits, and their FFRs were measured with a /da/ syllable (duration 40 milliseconds, speed 10.9/s), at 80 dB NA in the right ear. All procedures were approved by the ethical committee of the institution. Statistical analysis was performed using the t-Student or Mann-Whitney tests for quantitative variables, and the Fisher or chi-squared tests for qualitative variables, and a value of p < 0.05 was considered to be statistically significant.

Results There was no significant difference between the groups regarding auditory habits. In the FFR, wave amplitudes A (p = 0.01) and C (p = 0.04) were significantly lower in the Study Group.

Conclusion Working as a military pilot can be a crucial factor in determining an individual's typical FFR pattern, demonstrated in the present study by statistically significant reductions in the amplitudes of the A and C waves.
Changes in the Sensory Weighting Strategies in Balance Control Throughout Maturation in Children
Authors: Sinno Solara , Dumas Georges , Mallinson Art , Najem Fadi , Abouchacra Kim Smith , Nashner Lewis , Perrin Philippe
Published: December 2020

Abstract Background The central nervous system integrates information from different sensory inputs (vestibular, visual, and somatosensory) to maintain balance. However, strategies for weighing sensory information change as maturation occurs. Purpose The
purpose of this study was to: (1) evaluate postural control development in a large sample of healthy children aged 5 to 17 years old, (2) analyze changes in sensory weighting strategies as maturation occurs, and (3) determine the extent to which anthropometric characteristics (height, weight,
body mass index [BMI]) influence postural control. Sample Size This study recruited 120 healthy children, equally distributed in gender and number, into four age groups (5‐8 years, 9‐11 years, 12‐14 years, and 15‐17 years) and compared them to a
control group of 20 healthy adults (aged 20‐25 years). Research Design The sensory organization test (SOT) was used to assess overall balance and the use of specific sensory inputs to maintain postural control. All children underwent the six SOT conditions: (1) eyes
open, surround and platform stable, (2) eyes closed, surround and platform stable, (3) eyes open, sway-referenced surround, platform stable, (4) eyes open, sway-referenced platform, (5) eyes closed, sway-referenced platform, and (6) eyes open, sway-referenced surround and platform. Data
Analysis Condition-specific equilibrium scores (ES), composite equilibrium scores (CES), and sensory analysis ratios were analyzed to determine whether the performance was related to age, gender, or specific anthropometric characteristics (height, weight, and BMI). Results Data
showed a significant age-associated improvement in ES for all 6 conditions (p < 0.05) and in CES (p = 0.001). For both genders, (1) somatosensory function was adult-like by age 5 to 8 years, (2) visual function peaked around age 12 years, and (3)
vestibular function reached maturity by age 15 to 17 years (p < 0.05). A moderate positive correlation (r(140) = 0.684, p = 0.01; two-tailed) between height and CES was found and a weak positive correlation (r(140) = 0.198,
p = 0.01) between height and somatosensory ratio was noted. Lower vestibular ratio scores were observed in children who had a higher BMI (p = 0.001). Conclusion The efficient use of individual sensory system input to maintain balance
does not occur at the same age. Age and gender affect the changes in sensory weighting strategies, while height and BMI influence postural control in children. These factors need to be accounted for in child assessment.
Trigeminal Neuralgia Secondary to Intracranial Neoplastic Lesions: a Case Series and Comprehensive Review
Authors: Berra Luigi Valentino , Armocida Daniele , Mastino Lara , Rita Andrea Di , Norcia Valerio Di , Santoro Antonio , Piccirilli Manolo
Published: December 2020

It is known that intracranial tumors may trigger trigeminal neuralgia (TN) in some patients although the exact prevalence and occurrence is not completely defined yet. In the present study, we present a case series of patients with brain tumor and a clinical diagnosis of TN as the first and main manifestation of the disease. A retrospective analysis was performed involving patients diagnosed with brain tumor whose exclusive clinical feature our department focused on was TN. In addition, a review of all published cases was performed. From January 2017 to November 2018, 718 patients with brain tumor were admitted to our department, 17 of which suffered of TN, of which 8 patients presented with at least another neurologic symptom and 9 patients presented with TN alone, with typical symptoms of stubbing electric pain in 6 cases. In our series, we found that 2.3% of patients admitted for brain tumors had TN. In 0.8% of cases, TN was the main clinical symptom. The prevalence of tumor lesion in patients with facial neuropathic pain is not defined, but it is a well-known recognized initial symptom; however, early cerebral magnetic resonance imaging (MRI) is not yet strongly recommended in patients with newly diagnosed trigeminal neuralgia. The purpose of this article is, especially in unusual cases, to show that the application of such MR techniques and preoperative evaluation may contribute to diagnosis, indication, and surgery planning.
Psychosocial Well-Being of Adults Who Are Deaf or Hard of Hearing
Authors: Muñoz Karen , Baughman Kelsey , Meibos Alex , Ong Clarissa W. , Twohig Michael P.
Published: December 2020

Abstract Background Psychosocial well-being can interfere with engagement in activities of daily life. Consideration of psychosocial domains within hearing health care can expand audiologists' ability to understand treatment barriers and provide an opportunity
to jointly address challenges. Purpose This study explored psychosocial well-being and predictors among adults who are deaf or hard of hearing (DHH). Research Design Cross-sectional survey. Study Sample Two-hundred and sixty-nine surveys were
included in the analysis. Data Collection and Analysis Data were collected online. Backward elimination regression analyses were used to identify significant predictors of psychosocial well-being. Results Findings indicated most (∼70‐80%) of the respondents'
scores were below clinical cut-off for psychological distress, self-efficacy, quality of life, overall well-being, functioning, and relationship satisfaction, with the remainder falling between mild to severe clinical cut-offs. Psychological distress was predicted by more psychological inflexibility,
presence of additional disabilities, and younger age. Increased functional impairment was predicted by psychological inflexibility. Conclusion The majority of adults who are DHH in this study had positive indicators for psychosocial well-being. Screening patients for psychological
flexibility could be included in standard hearing health care practices to help clinicians identify individuals who may benefit from additional or different support.
Preliminary Examination of the Incidence of and Factors Related to Hearing Tinnitus in Dreams
Authors: Aazh Hashir , Stevens Jennifer , Moore Brian C.J.
Published: December 2020

Abstract Background and Purpose The aim of this study was to assess the incidence of the perception of tinnitus in dreams among patients seeking help for tinnitus and/or hyperacusis and to assess whether this is related to the severity of tinnitus and/or hyperacusis.
Research Design This was a retrospective study. Study Sample The data for 148 consecutive adult patients who attended a tinnitus/hyperacusis clinic in the United Kingdom were included. The average age of the patients was 56 years (standard deviation [SD] = 15
years). Data Collection Data were collected retrospectively from their records held at the audiology department. Audiological measures were pure-tone audiometry and uncomfortable loudness levels. Questionnaires administered were: Tinnitus Handicap Inventory (THI), Hyperacusis
Questionnaire, Insomnia Severity Index, Visual Analogue Scale (VAS) of tinnitus loudness, annoyance, and effect on life, Generalized Anxiety Disorder, and Patient Health Questionnaire. Patients were also asked “If you dream have you ever perceived tinnitus in your dreams?”
Results Five percent of patients (7/148) reported hearing tinnitus in their dreams. There was a nonsignificant trend for patients who reported hearing tinnitus in their dreams to be younger (mean age = 46 years, SD = 15 years) than those who did not
(mean age = 57 years, SD = 15 years). The mean scores for the THI and VAS for effect of tinnitus on life were significantly higher (worse) for patients who reported hearing tinnitus in their dreams than for those who did not. Conclusion A small proportion
of patients reported hearing tinnitus in their dreams and this was associated with higher tinnitus handicap as measured via the THI and more effect of tinnitus on life as measured via the VAS. These preliminary results may indicate that those who are greatly affected by their tinnitus are
more likely to hear it in their dreams or to be woken by it. Future studies should use methods that can be used to reliably assess if and when tinnitus is perceived during the sleep cycle, using more physiological measures and testing a wider population.
Validity of hearTest Smartphone-Based Audiometry for Hearing Screening in Workers Exposed to Noise
Authors: Rodrigues Luma Cordeiro , Ferrite Silvia , Corona Ana Paula
Published: December 2020

Abstract Purpose This article investigates the validity of a smartphone-based audiometry for hearing screening to identify hearing loss in workers exposed to noise. Research Design This is a validation study comparing hearing screening with the
hearTest to conventional audiometry. The study population included all workers who attended the Brazilian Social Service of Industry to undergo periodic examinations. Sensitivity, specificity, the Youden index, and positive (PPV) and negative predictive values (NPV) for hearing screening obtained
by the hearTest were estimated according to three definitions of hearing loss: any threshold greater than 25 dB hearing level (HL), the mean auditory thresholds for 0.5, 1, 2, and 4 kHz greater than 25 dB HL, and the mean thresholds for 3, 4, and 6 kHz greater than 25 dB
HL. Note that 95% confidence intervals were calculated for all measurements. Results A total of 232 workers participated in the study. Hearing screening with the hearTest presented good sensitivity (93.8%), specificity (83.9%), and Youden index (77.7%) values, a NPV (97.2%),
and a low PPV (69.0%) for the identification of hearing loss defined as any auditory threshold greater than 25 dB HL. For the other definitions of hearing loss, we observed high specificity, PPV and NPV, as well as low sensitivity and Youden index. Conclusion The hearTest
is an accurate hearing screening tool to identify hearing loss in workers exposed to noise, including those with noise-induced hearing loss, although it does not replace conventional audiometry.
Recent Advances in the Diagnosis and Treatment of Neonatal Seizures
Authors: Samanta Debopam
Published: December 2020

Seizures are the most common neurological emergency in the neonates, and this age group has the highest incidence of seizures compared with any other period of life. The author provides a narrative review of recent advances in the genetics of neonatal epilepsies, new neonatal seizure classification system, diagnostics, and treatment of neonatal seizures based on a comprehensive literature review (MEDLINE using PubMED and OvidSP vendors with appropriate keywords to incorporate recent evidence), personal practice, and experience. Knowledge regarding various systemic and postzygotic genetic mutations responsible for neonatal epilepsy has been exploded in recent times, as well as better delineation of clinical phenotypes associated with rare neonatal epilepsies. An International League Against Epilepsy task force on neonatal seizure has proposed a new neonatal seizure classification system and also evaluated the specificity of semiological features related to particular etiology. Although continuous video electroencephalogram (EEG) is the gold standard for monitoring neonatal seizures, amplitude-integrated EEGs have gained significant popularity in resource-limited settings. There is tremendous progress in the automated seizure detection algorithm, including the availability of a fully convolutional neural network using artificial machine learning (deep learning). There is a substantial need for ongoing research and clinical trials to understand optimal medication selection (first line, second line, and third line) for neonatal seizures, treatment duration of antiepileptic drugs after cessation of seizures, and strategies to improve neuromorbidities such as cerebral palsy, epilepsy, and developmental impairments. Although in recent times, levetiracetam use has been significantly increased for neonatal seizures, a multicenter, randomized, blinded, controlled phase IIb trial confirmed the superiority of phenobarbital over levetiracetam in the acute suppression of neonatal seizures. While there is no single best choice available for the management of neonatal seizures, institutional guidelines should be formed based on a consensus of local experts to mitigate wide variability in the treatment and to facilitate early diagnosis and treatment.
Interview mit Markus Wild: „Wenn wir wirklich müssen, dann kommen wir in Deutschland sehr schnell vorwärts“
Authors: Freye Carolin
Published: December 2020

Klinik Einkauf hat mit Markus Wild, CEO und Geschäftsführer der Prospitalia GmbH, über die Widrigkeiten des Jahres 2020 gesprochen und welche langfristigen Auswirkungen die Corona-Pandemie auf den Klinikeinkauf haben wird – sowohl im positiven als auch negativen Sinne.
Nonlinear dust ion acoustic shock wave structures in solar F corona region
Authors: Boro Birbaishri , Dev Apul N. , Saikia Bipul K. , Adhikary Nirab C.
Published: December 2020

Shock wave formation in dusty plasma consisting of mobile positive and negative ions, nonthermal electrons, and negatively charged static dust particles is theoretically studied in the presence of a magnetic field. Using the reductive perturbation technique, the basic set of fluid equations is reduced to the three-dimensional Zakarov–Kuznetsov Burgers nonlinear wave equation. The dissipation generated by ion kinematic viscosity in the system is taken into consideration. Distinct features of the dispersive (oscillatory) shock-like structures are discussed for different plasma parameters such as ion kinematic viscosities, ion density ratio, dust density ratio, nonthermal electrons, and magnetic field effect. It is observed that at large value of ion viscosities, nonthermal electrons, and ion density ratio, the formation of compressive shock strength increases. However, at certain critical values of nonthermal electrons, ion density ratio, the transition in the polarity of shock wave occurs within this range of plasma parameters. The considered parameters are reliable in the Solar F Corona (Dust corona) region. The findings of this work may be helpful in understanding shock formation in the Solar F Corona (Dust corona) region and astrophysical related plasma environments.
Spin wave propagation in a ferrimagnetic thin film with perpendicular magnetic anisotropy
Authors: Sheng Lutong , Liu Yawen , Chen Jilei , Wang Hanchen , Zhang Jianyu , Chen Mingfeng , Ma Ji , Liu Chuanpu , Tu Sa , Nan Ce-Wen , Yu Haiming
Published: December 2020

Iron garnets as an important type of low-damping magnetic insulator can provide an ideal platform for the field of magnonics. In this work, we study the propagation of spin waves in a 60 nm-thick TmIG film with perpendicular magnetic anisotropy using all-electrical spin wave spectroscopy. The magnetostatic forward volume mode spin waves show a fully reciprocal propagation. By sweeping out-of-plane magnetic fields in the low-field regime, spin textures are created and observed; meanwhile, the spin wave mode vanishes, which indicates that propagating spin waves are filtered by the spin textures. By applying a large in-plane field, spin wave propagation in a Damon–Eshbach configuration is studied. Our findings provide a potential method to explore reconfigurable magnonic devices.
Entropy production in model colloidal suspensions under shear via the fluctuation theorem
Authors: Desgranges Caroline , Delhommelle Jerome
Published: December 2020

Dissipative systems often exhibit novel and unexpected properties. This is, for instance, the case of simple liquids, which, when subjected to shear and after reaching a steady state, can exhibit a negative entropy production over finite length scales and timescales. This result, among others, is captured by nonequilibrium relations known as fluctuation theorems. Using nonequilibrium molecular dynamics simulations, we examine how, by fine-tuning the properties of the components of a complex fluid, we can steer the nonequilibrium response of the fluid. More specifically, we show how we control the nonequilibrium probability distribution for the shear stress and, in turn, how often states with a negative entropy production can occur. To achieve this, we start by characterizing how the size for the liquid matrix impacts the probability of observing negative entropy states, as well as the timescale over which these can be observed. We then measure how the addition of larger particles to this liquid matrix, i.e., simulating a model colloidal suspension, results in an increase in the occurrence of such states. This suggests how modifications in the composition of the mixture and in the properties of its components lead to an increase in the probability of observing states of negative entropy production and, thus, for the system to run in reverse.
Vibronic resonance is inadequately described by one-particle basis sets
Authors: Sahu Amitav , Kurian Jo Sony , Tiwari Vivek
Published: December 2020

Vibrational-electronic (vibronic) resonance and its possible role in energy and charge transfer have been experimentally and theoretically investigated in several photosynthetic proteins. Using a dimer modeled on a typical photosynthetic protein, we contrast the description of such excitons provided by an exact basis set description, as opposed to a basis set with reduced vibrational dimensionality. Using a reduced analytical description of the full Hamiltonian, we show that in the presence of vibrational excitation both on electronically excited as well as unexcited sites, constructive interference between such basis states causes vibronic coupling between excitons to become progressively stronger with increasing quanta of vibrational excitation. This effect leads to three distinguishing features of excitons coupled through a vibronic resonance, which are not captured in basis sets that restrict ground state vibrations: (1) the vibronic resonance criterion itself, (2) vibronically assisted perfect delocalization between sites even though purely electronic mixing between the sites is imperfect due to energetic disorder, and (3) the nuclear distortion accompanying vibronic excitons becoming increasingly larger for resonant vibronic coupling involving higher vibrational quanta. In terms of spectroscopically observable limitations of reduced basis set descriptions of vibronic resonance, several differences are seen in absorption and emission spectra but may be obscured on account of overwhelming line broadening. However, we show that several features such as vibronic exciton delocalization and vibrational distortions associated with electronic excitations, which ultimately dictate the excited state wavepacket motions and relaxation processes, are fundamentally not described by basis sets that restrict ground state vibrations.
An automated setup to measure the linear and nonlinear magnetic ac-susceptibility down to 4 K with higher accuracy
Authors: Dutta Biswajit , Kumar Kranti , Ghodke N. , Banerjee A.
Published: December 2020

An automated stepper motor controlled ac-susceptibility setup has been developed to measure the phase resolved linear and nonlinear magnetic ac-susceptibilities of a material in the temperature range of 4 K–300 K with a frequency range of 0.1 Hz–1.5 kHz. A maximum dc-field of ±150 Oe can be superimposed with a maximum ac-field of 100 Oe in the same coil by using a homemade ac–dc superimposing circuit. The induced voltage in the detection coil is measured by a lock-in amplifier, and temperature is controlled by a temperature controller. The very common offset voltage drifting problem is resolved by implementing a two-point measurement technique at every temperature, field, and frequency using a stepper motor. Operation of the stepper motor is controlled by a homemade computer programmable driver circuit. Sensitivity of the setup is obtained around ∼10−7 emu, and relative accuracy of the measurement is much better than 0.1%. Higher harmonics can be measured with a maximum noise level of ±15 nV throughout the temperature, field, and frequency range.
Brillouin’s theorem in the Hartree–Fock method: Eliminating the limitation of the theorem for excitations in the open shell
Authors: Plakhutin Boris N.
Published: December 2020

It is well known that Brillouin’s theorem (BT) holds in the restricted open-shell Hartree–Fock (ROHF) method for three kinds of single excitations, c → o, c → v, and o → v, where c, o, and v are the orbitals of the closed, open, and virtual shells, respectively. For these excitations, the conditions imposed by BT on the orbitals of a system under study are physically equivalent to the conditions imposed by the variational principle, and this provides a fundamental meaning of BT. Together with this, BT is not satisfied for some excitations of the kind o → o, in which both orbitals participating in excitation belong to the open shell. This limitation of BT is known, for example, for the helium atom, where BT is satisfied for excitation from the ground state S01 (1s2) to the state S11 of the configuration 1s12s1 and is not satisfied for excitations S11 → S01 and S11 → S21 (2s2). In this work, we prove that Brillouin’s conditions for two latter excitations cannot be related to the fundamental conditions imposed by the variational principle due to specific symmetry restrictions. Based on this finding, we give a rigorous proof of fulfillment of BT for the alternative o → o excitation, which takes in the helium atom the form S11 → S31, where both the initial and excited states are treated as arising from the same open-shell configuration 1s12s1, and the state S31 is described by the symmetry-adapted ROHF wave function Ψ(S31) = [Ψ(S21) − Ψ(S01)]/2. The new formulation of BT obeys all the necessary variational and symmetrical conditions, and its validity is illustrated by the results of computations of atom He and molecule LiH in their singlet states arising from different closed-shell and open-shell configurations performed using both ROHF and limited configuration interaction methods.
Corrigendum to: Continuous-Flow Photochemical Transformations of 1,4-Naphthoquinones and Phthalimides in a Concentrating Solar Trough Reactor
Authors: Yaseen Madyan A. , Mumtaz Saira , Hunter Richard L. , Wall Daniel , Robertson Mark J. , Oelgemöller Michael
Published: December 2020

A series of photochemical transformations has been successfully conducted under continuous-flow conditions in a concentrating solar trough reactor. Photoacylations and [2+2]-photocycloadditions involving 1,4-naphthoquinones gave the corresponding photoproducts in moderate to high yields with residence times of 70min. Likewise, acetone-sensitized photodecarboxylations involving phthalimides furnished the corresponding benzylated hydroxy phthalimidines in good to excellent yields and purity with residence times of 40min. Compared with corresponding exposures to direct sunlight conducted in a solar float, flow operation generally gave superior conversions and subsequent yields.