bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Potential Link between Acute Central Serous Chorioretinopathy and Trimethylamine N-Oxide, Phoenixin, Spexin, and Alarin Molecules
Authors: Kaya Mehmet Kaan , Arslan Sermal
Published: September 2023

Purpose: Acute central serous chorioretinopathy (ACSCR) is a condition characterized by decreased visual acuity, macular thickening, and edema under the retinal layer. Although the underlying mechanisms of the disease are not fully understood, oxidative stress is considered to be a critical risk factor. The aim of this study was to shed light on the pathophysiology of ACSCR by investigating the levels of circulating trimethylamine N-oxide (TMAO), phoenixin (PNX), alarin (ALA), and spexin (SPX) molecules in ACSCR patients. Methods: The study included 30 ACSCR patients and 30 healthy individuals as controls. ACSCR was diagnosed using optical coherence tomography (OCT) imaging. Five mL blood samples were collected from all participants following overnight fasting. The levels of TMAO, PNX, ALA, and SPX in the blood samples were measured using the ELISA method. Results: Visual acuity was found to be significantly reduced in ACSCR patients compared to the control group (<0.05), while macular thickness was increased (<0.05). Furthermore, TMAO, PNX, and ALA levels were significantly higher in ACSCR patients (<0.05), while SPX levels were significantly lower compared to the control group (<0.05). In ACSCR patients, there was a positive correlation between macular thickness and TMAO, PNX, and ALA; there was, however, a negative correlation with SPX. Additionally, visual acuity was negatively correlated with TMAO, PNX, and ALA, while SPX levels decreased as visual acuity decreased. Conclusions: These results demonstrate a correlation between the TMAO, PNX, ALA, and SPX levels of ACSCR patients and their visual acuity and macular thickness. Given the role of these molecules in ACSCR’s pathophysiology, they hold promise as potential diagnostic, therapeutic, and follow-up markers in the future.
Numerical Reconstruction of Cyclist Impact Accidents: Can Helmets Protect the Head-Neck of Cyclists?
Authors: Wang Fang , Peng Ke , Zou Tiefang , Li Qiqi , Li Fan , Wang Xinghua , Wang Jiapeng , Zhou Zhou
Published: September 2023

Cyclists are vulnerable road users and often suffer head-neck injuries in car–cyclist accidents. Wearing a helmet is currently the most prevalent protection method against such injuries. Today, there is an ongoing debate about the ability of helmets to protect the cyclists’ head-neck from injury. In the current study, we numerically reconstructed five real-world car–cyclist impact accidents, incorporating previously developed finite element models of four cyclist helmets to evaluate their protective performances. We made comparative head-neck injury predictions for unhelmeted and helmeted cyclists. The results show that helmets could clearly lower the risk of severe (AIS 4+) brain injury and skull fracture, as assessed by the predicted head injury criterion (HIC), while a relatively limited decrease in AIS 4+ brain injury risk can be achieved in terms of the analysis of CSDM0.25. Assessment using the maximum principal strain (MPS0.98) and head impact power (HIP) criteria suggests that helmets could lower the risk of diffuse axonal injury and subdural hematoma of the cyclist. The helmet efficacy in neck protection depends on the impact scenario. Therefore, wearing a helmet does not seem to cause a significant neck injury risk level increase to the cyclist. Our work presents important insights into the helmet’s efficacy in protecting the head-neck of cyclists and motivates further optimization of protective equipment.
Factors in Infancy That May Predict Autism Spectrum Disorder
Authors: Gurevitz Mina , Leisman Gerry
Published: September 2023

The global increase in the prevalence of ASD (Autism Spectrum Disorder) is of great medical importance, but the reasons for this increase are still unknown. This study sought to identify possible early contributing factors in children who were later diagnosed with ASD. In this retrospective cohort study, postnatal records of 1105 children diagnosed with ASD were analyzed to determine if any signs of ASD could be found in a large database of births and well-baby care programs. We compared the recordings of typically developing children and analyzed the differences statistically. Rapid increases in weight, height, and head circumference during early infancy predict the development of ASD. In addition, low birth weight, older maternal age, and increased weight and height percentiles at six months of age together predict the development of ASD. At two years of age, these four parameters, in addition to impaired motor development, can also predict the development of ASD. These results suggest that the recent increase in ASD prevalence is associated with the “obesity epidemic” and with recommendations of supine sleeping to prevent Sudden Infant Death Syndrome, associated with atypical neural network development in the brain.
Developing a Short-Form Buss–Warren Aggression Questionnaire Based on Machine Learning
Authors: Jiang Xiuyu , Yang Yitian , Li Junyi
Published: September 2023

For adolescents, high levels of aggression are often associated with suicide, physical injury, worsened academic performance, and crime. Therefore, there is a need for the early identification of and intervention for highly aggressive adolescents. The Buss–Warren Aggression Questionnaire (BWAQ) is one of the most widely used offensive measurement tools. It consists of 34 items, and the longer the scale, the more likely participants are to make an insufficient effort response (IER), which reduces the credibility of the results and increases the cost of implementation. This study aimed to develop a shorter BWAQ using machine learning (ML) techniques to reduce the frequency of IER and simultaneously decrease implementation costs. First, an initial version of the short-form questionnaire was created using stepwise regression and an ANOVA F-test. Then, a machine learning algorithm was used to create the optimal short-form questionnaire (BWAQ-ML). Finally, the reliability and validity of the optimal short-form questionnaire were tested using independent samples. The BWAQ-ML contains only four items, thirty items less than the BWAQ, and its AUC, accuracy, recall, precision, and F1 score are 0.85, 0.85, 0.89, 0.83, and 0.86, respectively. BWAQ-ML has a Cronbach’s alpha of 0.84, a correlation with RPQ of 0.514, and a correlation with PTM of −0.042, suggesting good measurement performance. The BWAQ-ML can effectively measure individual aggression, and its smaller number of items improves the measurement efficiency for large samples and reduces the frequency of IER occurrence. It can be used as a convenient tool for early adolescent aggression identification and intervention.
Evaluating the Relative Perceptual Salience of Linguistic and Emotional Prosody in Quiet and Noisy Contexts
Authors: Zhang Minyue , Zhang Hui , Tang Enze , Ding Hongwei , Zhang Yang
Published: September 2023

How people recognize linguistic and emotional prosody in different listening conditions is essential for understanding the complex interplay between social context, cognition, and communication. The perception of both lexical tones and emotional prosody depends on prosodic features including pitch, intensity, duration, and voice quality. However, it is unclear which aspect of prosody is perceptually more salient and resistant to noise. This study aimed to investigate the relative perceptual salience of emotional prosody and lexical tone recognition in quiet and in the presence of multi-talker babble noise. Forty young adults randomly sampled from a pool of native Mandarin Chinese with normal hearing listened to monosyllables either with or without background babble noise and completed two identification tasks, one for emotion recognition and the other for lexical tone recognition. Accuracy and speed were recorded and analyzed using generalized linear mixed-effects models. Compared with emotional prosody, lexical tones were more perceptually salient in multi-talker babble noise. Native Mandarin Chinese participants identified lexical tones more accurately and quickly than vocal emotions at the same signal-to-noise ratio. Acoustic and cognitive dissimilarities between linguistic prosody and emotional prosody may have led to the phenomenon, which calls for further explorations into the underlying psychobiological and neurophysiological mechanisms.
Bamboo as Sustainable Building Materials: A Systematic Review of Properties, Treatment Methods, and Standards
Authors: Adier Maria Fe V. , Sevilla Maria Emilia P. , Valerio Daniel Nichol R. , Ongpeng Jason Maximino C.
Published: September 2023

Bamboo is the building material of the past and future. It offers numerous properties that make it versatile for various applications, including construction. Its impressive strength-to-weight ratio enables it to bear substantial loads and stresses, while its good elasticity allows efficient energy absorption. However, its mechanical properties can vary based on factors such as species, age, locations, methods, and treatment. Treating bamboo is essential to enhance its properties and durability. The literature provides various natural and chemical treatments that enhance some of the properties but also reported drawbacks regarding higher temperature, content, and duration. This paper reviewed 57 articles from the Scopus database, specifically focusing on article–document-type publications from the years 2003 to 2023. Additional references were also incorporated to address concerns in properties, treatment, and standards to provide systematic understanding. With extensive assessment of the articles, the following gaps and concerns were observed, and recommendations for further study and assessment were made: the bamboo’s properties, the development of centralized guidelines and procedures for the preparation and processing; the exploration of alternative materials to reinforce bamboo without compromising its ductility; and the development of joint connections, and testing of mechanical properties considering seismic, wind and vibration. For treatment methods, the standardization of procedures using natural, chemical, or a combination. Lastly, for bamboo codes and standards, the assessment of existing codes and standards for testing the mechanical properties of bamboo, highlighting the potential limitations and areas, uniformity, and differences with all existing similar standards. By filling these gaps, it can support the reliability and robustness of bamboo as a sustainable material, fostering its promotion and adoption in the construction industry.
Analysis of Cooling Load Characteristics in Chinese Residential Districts for HVAC System Design
Authors: An Jingjing , Zhou Xin , Yan Da
Published: September 2023

Energy consumption in residential buildings accounts for a large portion of global energy use. Understanding residential building load characteristics is important in both the design and technical suitability analysis of residential air conditioning systems in terms of energy efficiency and carbon reduction. However, most current research mainly focuses on the load characteristics of individual buildings and not on the variation in load characteristics of building aggregation. In addition, the load characteristics of building aggregations vary with the building scale; however, most studies have compared those of buildings under a certain scale, and the change with the increase in building scale is still unclear. The main purpose of this study is to explore load characteristic differences among residential buildings of different scales and the impacts of those differences on HVAC system design. Based on the monitoring data collected in a residential district in Zhengzhou, China, we analyzed the load characteristics among different households and combinations of different numbers of households from the variation in peak load, total consumption and load distribution, as well as the daily load volatility. We indicate that the load characteristics of heating, ventilation and air conditioning systems of different scales should be considered in the design and operation stage.
Prediction of Progressive Frost Damage Development of Concrete Using Machine-Learning Algorithms
Authors: Atasham ul haq Muhammad , Xu Wencheng , Abid Muhammad , Gong Fuyuan
Published: September 2023

Understanding the deterioration mechanism of concrete structures in cold climates that are susceptible to frost damage from repeated freezing and thawing cycles is imperative for ensuring their durability and serviceability. This study analyzed the impact of freeze–thaw (FT) exposure on concrete structural behavior by developing three machine-learning approaches—artificial neural networks (ANN), random forests (RF), and support vector machines (SVM)—to quantify the progressive loss in compressive strength after repeated FT cycles. The results demonstrate that all of the proposed models can predict the deteriorated compressive strength of concrete and align closely with the experimental results. The ANN model demonstrated the highest prediction accuracy with an R2 of 0.924, exhibiting a higher prediction accuracy than RF and SVM models. Sensitivity analysis using Shapley additive explanations (SHAP) revealed that concrete with an initially high strength, along with a lower water–cement ratio and air entrainment, exhibited the least reduction in compressive strength after freezing–thawing cycles, underlining the positive impact of these factors on the FT durability of concrete. The proposed modeling approach accurately predicts the residual compressive strength after FT exposure, enabling the selection of optimal concrete materials and structural designs for cold climates.
Driving Factors of Concession Period in Healthcare Public Private Partnerships
Authors: Castelblanco Gabriel , Safari Pourya , De Marco Alberto
Published: September 2023

Public Private Partnerships (PPPs) play a vital role in infrastructure development and public service delivery, with government entities collaborating with private sector organizations to achieve shared goals in the long term. An essential aspect of PPP contracts is the concession period, during which Special Purpose Vehicles (SPVs) are responsible for financing, building, operating, and maintaining public assets. The concession period has significant implications, associated with project risk, revenue, operations expenses, profitability, and bankability. While numerous studies focus on determining “optimal” concession periods, fewer explore the factors driving concession periods in national PPP programs, especially for social infrastructure projects relying primarily on availability payments. To fill this gap, this research aims to identify and analyze the effect of various potential factors on the length of the concession period, using linear regression analysis on a data set of healthcare PPP projects in Italy. This research theoretically contributes to understanding the driving factors of concession periods in PPP projects and provides insights for a balanced approach to PPP project planning and regulation and related strategies. On the practical side, decision makers can negotiate optimized concession periods, ensuring successful and sustainable public infrastructure projects.
Global Research Trends in Engineered Soil Development through Stabilisation: Scientific Production and Thematic Breakthrough Analysis
Authors: Ravindran Gobinath , Bahrami Alireza , Mahesh Vutukuru , Katman Herda Yati Binti , Srihitha Katakam , Sushmashree Alamadri , Nikhil Kumar Alugoju
Published: September 2023

Soil, a naturally occurring resource, is increasingly used as a construction material. Stabilisation strengthens soil, which is weak as an engineering material. Stabilising soil changes its physical qualities, enhancing its strength. Soil stabilisation increases the shear strength and load-bearing capacity. Soil stabilisation refers to any endeavour to change natural soil for engineering purposes using physical, chemical, mechanical, or biological methods, or a mix of these. Strengthening road pavements includes improving the load-bearing capacity, tensile strength, and performance of unstable subsoils, sands, and waste materials. Due to market demands and scientific advances, the number of soil-stabilising additives has increased. These innovative stabilisers include reinforcing fibres, calcium chloride, sodium chloride, and cross-linking water-based styrene acrylic polymers, which are geopolymers that boost the load-bearing capacity and tensile strength of soil. Many materials are being explored for soil stabilisation. In this article, the authors investigated the direction of soil stabilisation research. Scientometric analysis identifies stabilisation challenges and research trends in the field. This study analysed research patterns by countries, authors, institutions, keywords, and journals from 1959 to 2023; in 2021, 150 articles were published, which was the highest number in a year. Citations peaked at 3084 in 2022. With 253 publications and 3084 citations, India was the most productive country. Iran and France published the fewest, 34 and 33, respectively. The Islamic Azad University and the National Institute of Technology had the fewest published articles with 17 articles. This work can help track soil stabilisation research and will serve as an information document for future research.
Oncolytic Viral Therapy for Glioma by Recombinant Sindbis Virus
Authors: Sun Kangyixin , Shi Xiangwei , Li Li , Nie Xiupeng , Xu Lin , Jia Fan , Xu Fuqiang
Published: September 2023

Background: The characteristics of glioblastoma, such as drug resistance during treatment, short patient survival, and high recurrence rates, have made patients with glioblastoma more likely to benefit from oncolytic therapy. Methods: In this study, we investigated the safety of the sindbis virus by injecting virus intravenously and intracranially in mice and evaluated the therapeutic effect of the virus carrying different combinations of IL-12, IL-7, and GM-CSF on glioma in a glioma-bearing mouse model. Results: SINV was autologously eliminated from the serum and organs as well as from neural networks after entering mice. Furthermore, SINV was restricted to the injection site in the tree shrew brain and did not spread throughout the whole brain. In addition, we found that SINV-induced apoptosis in conjunction with the stimulation of the immune system by tumor-killing cytokines substantially suppressed tumor development. It is worth mentioning that SINV carrying IL-7 and IL-12 had the most notable glioma-killing effect. Furthermore, in an intracranial glioma model, SINV containing IL-7 and IL-12 effectively prolonged the survival time of mice and inhibited glioma progression. Conclusions: These results suggest that SINV has a significant safety profile as an oncolytic virus and that combining SINV with cytokines is an efficient treatment option for malignant gliomas.
The Evolution of Neo-Adjuvant Therapy in the Treatment of Oesophageal and Gastro-Oesophageal Junction Adenocarcinomas
Authors: Dermanis Alexander A. , Kamarajah Sivesh K. , Tan Benjamin
Published: September 2023

Historically, oesophageal and gastro-oesophageal junction adenocarcinomas were associated with a poor prognosis. The advent of neoadjuvant therapy has transformed the management of oesophageal and gastro-oesophageal junction adenocarcinomas further and offers the possibility to reverse disease progression, eliminate micrometastasis, and offer potentially better outcomes for these patients. This review provides an overview of landmark clinical trials in this area, with different treatment regimens considered over the years as well as potential therapeutic agents on the horizon that may transform the management of oesophageal and gastro-oesophageal junction adenocarcinomas further.
Differential Immune Infiltration Profiles in Colitis-Associated Colorectal Cancer versus Sporadic Colorectal Cancer
Authors: Schardey Josefine , Lu Can , Neumann Jens , Wirth Ulrich , Li Qiang , Jiang Tianxiao , Zimmermann Petra , Andrassy Joachim , Bazhin Alexandr V. , Werner Jens , Kühn Florian
Published: September 2023

Background: Chronic inflammation is a significant factor in colorectal cancer (CRC) development, especially in colitis-associated CRC (CAC). T-cell exhaustion is known to influence inflammatory bowel disease (IBD) progression and antitumor immunity in IBD patients. This study aimed to identify unique immune infiltration characteristics in CAC patients. Methods: We studied 20 CAC and 20 sporadic CRC (sCRC) patients, who were matched by tumor stage, grade, and location. Immunohistochemical staining targeted various T-cell markers (CD3, CD4, CD8, and FOXP3), T-cell exhaustion markers (TOX and TIGIT), a B-cell marker (CD20), and a neutrophil marker (CD66b) in tumor and tumor-free mucosa from both groups. The quantification of the tumor immune stroma algorithm assessed immune-infiltrating cells. Results: CAC patients had significantly lower TOX+ cell infiltration than sCRC in tumors (p = 0.02) and paracancerous tissues (p < 0.01). Right-sided CAC showed increased infiltration of TOX+ cells (p = 0.01), FOXP3+ regulatory T-cells (p < 0.01), and CD20+ B-cells (p < 0.01) compared to left-sided CAC. In sCRC, higher tumor stages (III and IV) had significantly lower TIGIT+ infiltrate than stages I and II. In CAC, high CD3+ (p < 0.01) and CD20+ (p < 0.01) infiltrates correlated with improved overall survival. In sCRC, better survival was associated with decreased TIGIT+ cells (p < 0.038) and reduced CD8+ infiltrates (p = 0.02). Conclusion: In CAC, high CD3+ and CD20+ infiltrates relate to improved survival, while this association is absent in sCRC. The study revealed marked differences in TIGIT and TOX expression, emphasizing distinctions between CAC and sCRC. T-cell exhaustion appears to have a different role in CAC development.
A Family with a Single LMNA Mutation Illustrates Diversity in Cardiac Phenotypes Associated with Laminopathic Progeroid Syndromes
Authors: Giguet-Valard Anna-Gaëlle , Monfort Astrid , Lucron Hugues , Mosbah Helena , Boccara Franck , Vatier Camille , Vigouroux Corinne , Richard Pascale , Wahbi Karim , Bellance Remi , Sarrazin Elisabeth , Inamo Jocelyn
Published: September 2023

The likely pathogenic variant c.407A>T p.Asp136Val of the LMNA gene has been recently described in a young woman presenting with atypical progeroid syndrome, associated with severe aortic valve stenosis. We further describe the cardiovascular involvement associated with the syndrome in her family. We identified seven members with a general presentation suggestive of progeroid syndrome. All of them presented heart conduction abnormalities: degenerative cardiac diseases such as coronary artery disease (two subjects) and aortic stenosis (three subjects) occurred in the 3rd–5th decade, and a young patient developed a severe dilated cardiomyopathy, leading to death at 15 years of age. The likely pathogenic variant was found in all the patients who consented to carry out the genetic test. This diverse family cardiologic phenotype emphasizes the complex molecular background at play in lamin-involved cardiac diseases, and the need for early and thorough cardiac evaluations in patients with laminopathic progeroid syndromes.
Effects of Weight Loss and Aerobic Exercise Training on Adi-Pose Tissue Zinc α2-Glycoprotein and Associated Genes in Obesity
Authors: Ge Shealinna X. , Li Guoyan , Ryan Alice S.
Published: September 2023

Zinc α2-glycoprotein (ZAG) has been implicated in fatty acid metabolism and utilization and is lower in obese and higher in cachexic adults compared to those of normal weight. Previous studies suggest that ZAG binds to the beta3-adrenergic receptor (β3AR) to influence fatty acid metabolism in adipose tissue by regulating hormone sensitive lipase (HSL). The purpose of this study is to investigate the effects of a six-month weight loss (WL) or aerobic exercise (AEX) intervention on adipose tissue and skeletal muscle ZAG mRNA levels and protein expression, as well as the expression of β3AR, and HSL. Abdominal adipose tissue (AB) and gluteal adipose tissue (Glut) and vastus lateralis muscle biopsies were performed before and after WL (n = 13) or AEX (n = 13). ZAG, HSL, and β3AR expressions were determined by RT-PCR, and ZAG and HSL plasma levels by ELISA. Body weight decreased by 9.69% (p < 0.001) in WL and did not change with AEX. Maximal oxygen consumption (VO2max) increased by 7.1% (p < 0.005) after WL and by 16.69% (p < 0.001) after AEX. WL significantly decreased body weight with a reduction of percentage of fat, fat mass, fat-free mass (FFM). AEX decreased percent fat and increased VO2max, but did not change fat mass and FFM. Abdominal ZAG and HSL mRNA levels did not change significantly after WL or AEX. There were no changes in plasma ZAG, HSL and adipose tissue β3AR mRNA levels after WL and AEX. ZAG, HSL and β3AR mRNA expressions in adipose tissue are positively associated each other. Adipose tissue abdominal and gluteal HSL are negatively associated with HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), and both ZAG and HSL adipose tissue are negatively associated with fasting glucose and the glucose area under the curve. Further work is needed to elucidate the role of ZAG and HSL in the propensity for weight gain and the ability of exercise to mitigate these responses.
Normalization of the ATP1A1 Signalosome Rescinds Epigenetic Modifications and Induces Cell Autophagy in Hepatocellular Carcinoma
Authors: Rajan Pradeep Kumar , Udoh Utibe-Abasi S. , Nakafuku Yuto , Pierre Sandrine V. , Sanabria Juan
Published: September 2023

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. In metabolic dysfunction-associated steatohepatitis (MASH)-related HCC, cellular redox imbalance from metabolic disturbances leads to dysregulation of the α1-subunit of the Na/K-ATPase (ATP1A1) signalosome. We have recently reported that the normalization of this pathway exhibited tumor suppressor activity in MASH-HCC. We hypothesized that dysregulated signaling from the ATP1A1, mediated by cellular metabolic stress, promotes aberrant epigenetic modifications including abnormal post-translational histone modifications and dysfunctional autophagic activity, leading to HCC development and progression. Increased H3K9 acetylation (H3K9ac) and H3K9 tri-methylation (H3K9me3) were observed in human HCC cell lines, HCC-xenograft and MASH-HCC mouse models, and epigenetic changes were associated with decreased cell autophagy in HCC cell lines. Inhibition of the pro-autophagic transcription factor FoxO1 was associated with elevated protein carbonylation and decreased levels of reduced glutathione (GSH). In contrast, normalization of the ATP1A1 signaling significantly decreased H3K9ac and H3K9me3, in vitro and in vivo, with concomitant nuclear localization of FoxO1, heightening cell autophagy and cancer-cell apoptotic activities in treated HCC cell lines. Our results showed the critical role of the ATP1A1 signalosome in HCC development and progression through epigenetic modifications and impaired cell autophagy activity, highlighting the importance of the ATP1A1 pathway as a potential therapeutic target for HCC.
Flow and Influencing Factors of Coated Slag in Continuous Casting Mold
Authors: Du Fengming , Wang Shanjiao , Zheng Gengtao
Published: September 2023

In the continuous casting, the protective slag is coated on the surface of the molten steel, which is an important factor affecting the quality of the billet. The liquid slag layer on the surface of molten steel should be kept at an appropriate thickness to ensure a sufficient supply of liquid slag and to prevent slag from becoming entangled in the billet shell. Moreover, the consumption of protective slag should be appropriate to ensure stable liquid slag film thickness and uniform heat transfer between the casting billet and the mold. In this work, a two-dimensional numerical calculation model using volume of fluid method was established for the flow of protective slag, the Navier–Stokes equation was solved for the model, the consumption of protective slag during a vibration cycle was calculated, and the effects of factors such as casting speed, amplitude, and vibration frequency on the consumption of protective slag were explored. The results showed that when the casting speed increased from 1.2 m/min to 1.6 m/min, the consumption of protective slag per unit area decreased by about 4.76%, but the consumption of protective slag per unit length of the casting billet increased by about 26.98% within a vibration cycle. The consumption of protective slag per unit area and per unit billet length within a vibration cycle increased slightly with the increase of amplitude. The variation pattern of the consumption of protective slag with vibration frequency was not obvious. This model can provide theoretical basis and technical guidance for the design of protective slag, thereby improving the quality of steel billets in steel plants.
Analysis of the High Temperature Plastic Deformation Characteristics of 18CrNi4A Steel and Establishment of a Modified Johnson–Cook Constitutive Model
Authors: Wang Zhen , Jiang Chuang , Wei Bingyang , Wang Yongqiang
Published: September 2023

To investigate the plastic deformation behavior of 18CrNi4A steel at high temperatures, an isothermal hot compression test was conducted on a Thermecmastor-Z series test machine at deformation temperatures from 1273 K to 1423 K and strain rates ranging from 0.01 s−1 to 10 s−1. The effects of these two factors on the flow stress were analyzed. Based on the true stress–strain experimental curves, the original Johnson–Cook constitutive model was applied to determine the flow stress data under different deformation conditions. The prediction results of the model were compared with the experimental data. The main reason for the large deviation observed between them was that the coupling relationship between the deformation temperature and the strain rate was not considered, so the original Johnson–Cook model was modified. The correlation coefficient and average absolute relative error of the original Johnson–Cook model were 0.962 and 16.36%. The prediction accuracy of the modified Johnson–Cook model was improved to 0.991 and 5.58%, respectively. The results show that the modified Johnson–Cook model exhibits higher prediction precision, which is beneficial for the broader application of 18CrNi4A steel in the industry.
Relationships between Strength, Ductility and Fracture Toughness in a 0.33C Steel after Quenching and Partitioning (Q&P) Treatment
Authors: Tkachev Evgeniy , Borisov Sergey , Borisova Yuliya , Kniaziuk Tatiana , Kaibyshev Rustam
Published: September 2023

The effect of quenching and partitioning (Q&P) processing on strength, ductility and fracture toughness is considered in a 0.33% C-1.8% Si-1.44 Mn-0.58% Cr steel. The steel was fully austenitized at 900 °C and quenched to 210 °C for 30 s. Partitioning at 350 °C for 600 s produces a martensitic matrix with transition carbides, bainitic ferrite and film-like retained austenite (RA) that is stable against transformation to strain-induced martensite under tension. This processing provided the highest strength and fracture toughness but the lowest ductility and product of strength and elongation (PSE), σB·δ (MPa·%). Partitioning at 500 °C produced RA with a relatively low carbon content and low volume fraction of carbides. The steel after this Q&P processing exhibits the highest ductility and PSE but low YS and Charpy V-notch (CVN) impact toughness. High ductility and PSE correlate with the ability of RA to transform into strain-induced martensite, while high strength and impact toughness are associated with the high-volume fraction of transition carbides in the carbon-depleted martensitic matrix and a lack of transformation of RA to strain-induced martensite. The highest CVN impact energy was attained in the steel exhibiting transgranular quasi-cleavage fracture with the lowest effective grain size for brittle fracture. No correlation between strength, ductility and fracture toughness is observed in Q&P steels if these materials have distinct structural constituents.
Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the Disease
Authors: Pérez-Hernández Jesús , León-Díaz Rosalba , Zentella Alejandro , Lamoyi Edmundo , Esquivel-Velázquez Marcela , Barranca-Enríquez Antonia , Romo-González Tania
Published: September 2023

Breast cancer (BC) is the most frequent malignant neoplasia and leading cause of cancer mortality for women. A timely diagnosis of BC is crucial to ensure the best chances of survival. Among the various screening tools for BC, antibodies directed towards self-antigens or tumor-associated antigens (autoantibodies) have emerged as an alternative to image-based screening modalities. However, little attention has been paid to the global diversity of autoantibodies. This work aimed to analyze the diversity of autoantibodies reactive to antigens expressed by the BC cell line T47D in the sera of Mexican women with BC, benign breast pathology (BBP), or without breast pathology (WBP). We found that the diversity of antibodies in the sera was higher in the BC and BBP groups than in the WBP group. Likewise, the diversity changed with the progression of BC. Our results show and measure the complexity of the antibody response in breast health and disease.
Identification of Early Biochemical Recurrence Predictors in High-Risk Prostate Cancer Patients Treated with Carbon-Ion Radiotherapy and Androgen Deprivation Therapy
Authors: Utsumi Takanobu , Suzuki Hiroyoshi , Ishikawa Hitoshi , Wakatsuki Masaru , Okonogi Noriyuki , Harada Masaoki , Ichikawa Tomohiko , Akakura Koichiro , Murakami Yoshitaka , Tsuji Hiroshi , Yamada Shigeru
Published: September 2023

The aim of this retrospective study was to identify clinical predictors of early biochemical recurrence (BCR) in patients with high-risk prostate cancer (PCa) treated with carbon-ion radiotherapy (CIRT) and androgen deprivation therapy (ADT). A total of 670 high-risk PCa patients treated with CIRT and ADT were included in the study. Early BCR was defined as recurrence occurring during adjuvant ADT after CIRT or within 2 years after completion of ADT. Univariate and multivariate analyses were performed to identify clinical predictors of early BCR. Patients were also classified according to the Systemic Therapy in Advancing or Metastatic Prostate cancer (STAMPEDE) PCa classification. Early BCR was observed in 5.4% of the patients. Multivariate analysis identified clinical T3b stage and ≥75% positive biopsy cores as clinical predictors of early BCR after CIRT and ADT. The STAMPEDE PCa classification was also significantly associated with early BCR based on univariate analysis. These predictors can help clinicians identify patients who are at risk of early BCR. In the future, combination therapy of ADT with abiraterone may be an option for high-risk PCa patients who are at risk of early BCR, based on the results of the STAMPEDE study.
Phylogeography of Ara militaris (Military Macaw): Implications for Conservation
Authors: Rivera-Ortíz Francisco A. , Sanabria-Urbán Salomón , Prieto-Torres David A. , Navarro-Sigüenza Adolfo G. , Arizmendi María del C. , Oyama Ken
Published: September 2023

The Military Macaw (Ara militaris) is an endangered bird species with disjunct geographic distribution across the Neotropics, consisting of three recognized subspecies: One in Mexico (A. m. mexicanus) and two in South America (A. m. militaris and A. m. bolivianus). However, due to the limited phenotypic differentiation between these allopatric taxa, their taxonomic status has been the subject of debate. In this study, we explored mitochondrial DNA (mtDNA) variability to determine the phylogeographical pattern through phylogenetic and ecological modelling analyses. We also aimed to describe the evolutionary relationships of twelve A. militaris populations. We identified 41 haplotypes in the 300 bp region of the Cytochrome b (Cyt-b) gene of the mtDNA and low nucleotide diversity. The observed phylogeographic structure suggests the existence of two clades: One composed of A. m. militaris and A. m. bolivianus and another consisting solely of A. m. mexicanus. The A. m. mexicanus clade further divides into two recognized subclades: Sierra Madre Oriental and northeastern portion of the Sierra Madre Occidental. Ecological analyses revealed that the niche similarity between these lineages was lower than expected by chance. Additionally, results from low cross-prediction tests indicated that the two lineages have inhabited different environmental spaces since the Late Pleistocene. This divergence may be associated with a steep ecological gradient and contemporary geographical barrier. Based on our results, we suggest that at least the A. m. mexicanus has a divergent evolutionary history; therefore, it should be considered as a different evolutionarily significant and management unit. We recommend that future conservation strategies in Mexico incorporate effective protection measures, including habitat preservation and the reduction of illegal trade, to ensure the preservation of viable populations.
Genetic Structure of Juvenile Stages of Phocanema bulbosum (Nematoda, Chromadorea: Anisakidae) Parasitizing Commercial Fish, Atlantic Cod Gadus morhua, and American Plaice Hippoglossoides platessoides in the Barents Sea
Authors: Gordeev Ilya I. , Bakay Yuri I. , Kalashnikova Marina Yu. , Logvinenko Andrey D. , Emelianova Olga R. , Sokolov Sergey G.
Published: September 2023

Atlantic cod Gadus morhua and American plaice Hippoglossoides platessoides are two of the most commercially valuable species in the Barents Sea (FAO Area 27). They are considered as an important but neglected source of zoonotic risk associated with nematodes from the genus Phocanema. The abundance of Phocanema spp. in a fish host individual in the Barents Sea may be quite high, which is convenient for studying the genetic structure of its populations. A total of 69 third-stage juveniles of Phocanema spp. were isolated from the liver, the mesentery, and the musculature of G. morhua and H. platessoides and genotyped by the mtDNA Cox2 gene. Almost all these juveniles (68) were molecularly identified as P. bulbosum. The mtDNA Cox2 gene was also used to reveal the haplotype diversity and the genetic structure of P. bulbosum. A comparison of the specimens examined in this study with each other and with the haplotypes previously identified by us in the White Sea showed that there were no significant differences between the groups from different hosts and from different catch areas.
Membranous Expression of Heart Development Protein with EGF-like Domain 1 Is Associated with a Good Prognosis in Patients with Bladder Cancer
Authors: Mori Kohei , Matsumoto Kazumasa , Ikeda Masaomi , Koguchi Dai , Shimizu Yuriko , Tsumura Hideyasu , Ishii Daisuke , Tsuji Shoutaro , Sato Yuichi , Iwamura Masatsugu
Published: September 2023

Objective: To investigate the correlation between total protein expression of heart development protein with EGF-like domain 1 (HEG1) and clinicopathological characteristics in patients with bladder cancer (BC) after radical cystectomy (RC). Patients and Methods: We retrospectively analyzed data from 110 patients who underwent RC at Kitasato University Hospital. And we prepared an anti-HEG1 monoclonal antibody W10B9, which can detect total HEG1 protein. HEG1 protein expression in tumor cells was evaluated separately for membrane and cytoplasmic staining using immunohistochemistry. Results: Membranous HEG1 expression was associated with absent lymphovascular invasion (p < 0.01) and low pT stage (p < 0.01). Kaplan–Meier analysis revealed that the membranous HEG1-positive group had significantly long recurrence-free survival (RFS) (p < 0.01) and cancer-specific survival (p = 0.01). Expression of membranous HEG1 was identified as an independent prognostic factor for RFS (p = 0.04). There were no significant differences between cytoplasmic HEG1 expression and clinicopathologic factors including prognosis. Conclusion: The expression of membranous HEG1 could serve as a favorable prognostic indicator in patients with BC treated with RC.
Information Leakage Rate of Optical Code Division Multiple Access Network Using Wiretap Code
Authors: Xu Rongwo , Sun Leiming , Ji Jianhua , Wang Ke , Song Yufeng
Published: September 2023

Secrecy capacity is usually employed as the performance metric of the physical layer security in fiber-optic wiretap channels. However, secrecy capacity can only qualitatively evaluate the physical layer security, and it cannot quantitatively evaluate the physical layer security of an imperfect security system. Furthermore, secrecy capacity cannot quantitatively evaluate the amount of information leakage to the eavesdropper. Based on the channel model of an optical CDMA network using wiretap code, the information leakage rate is analyzed to evaluate the physical layer security. The numerical results show that the information leakage rate can quantitatively evaluate the physical layer security of an optical CDMA wiretap channel, and it is related to transmission distance, eavesdropping position, confidential information rate and optical code.
A Hybrid Solar-RF Energy Harvesting System Based on an EM4325-Embedded RFID Tag
Authors: Veloo Samrrithaa G. , Tiang Jun Jiat , Muhammad Surajo , Wong Sew Kin
Published: September 2023

This paper presents the deployment of a hybrid energy harvesting system that combines a wireless energy harvesting (EH) system and a 6 V, 170 mA monocrystalline solar energy derived from the Sun’s rays. The hybrid energy harvesting (HEH) system comprises the rectifier, the solar cell panel, the charging circuit, and the EM4325 embedded RFID tag. This study aims to design an efficient EH system capable of increasing the read range of an active RFID tag. The proposed approach integrates a meandered line radio frequency identification (RFID) tag with an EM4325 IC chip as the receiver antenna. A halfwave doubler RF rectifier circuit is connected to the antenna using a 50 Ω SMA connector to convert the captured RF waves into usable electrical power. A solar energy charging module equipped with a Maximum Power Point Tracking (MPPT) system, a rechargeable lithium-ion battery, and a DC-DC converter is configured to manage and store the harvested energy efficiently. The UHF tag antenna operates at 919 MHz, achieving a peak gain of 3.54 dB. The proposed rectenna achieves a maximum measured harvested power conversion efficiency (PCE) of 55.14% for an input power (Pin) of 15 dBm at a distance of 5.10 cm, while the solar cell panel realizes 3.92 W of power. Experimental results demonstrate the hybrid harvester system’s effectiveness, achieving a PCE of 86.49% at an output voltage (VDC) of 5.35 V. The main advantage of this approach is the creation of a compact hybrid RF and solar EH system by combining the solar cell panel with the antenna, thus enabling multi-functionality.
Research on the Application of Heterogeneous Cellular Automata in the Safety Control and Detection System of Construction Project Implementation Phase
Authors: Chen Zeyou , Zhang Zheyuan , Xiang Yong , Wei Yao
Published: September 2023

In construction engineering safety management, the problem of construction workers’ unsafe behavior (CWUB) has always been a focus for researchers as well as practice managers. Currently, most studies focus on the influencing factors and mechanisms of (CWUB), with less attention given to the dissemination process and control effects of CWUB. Therefore, this paper aims to investigate a safety control detection system for the transmission process. The heterogeneous cellular automaton (CA) has advantages in constructing such a system as it can reflect the interactive processes of construction workers from micro to macro, local to global, and consider the heterogeneity of individuals and space, satisfying unequal interaction probabilities between individuals and spatial variations in characteristics. The SEIR model accurately categorizes construction workers and visually represents the changing quantities of different state groups at each stage. It effectively describes the process of CWUB transmission among construction workers. Based on the aforementioned foundation, a safety control and monitoring system was proposed for the implementation stages of the project. Finally, the control detection system is simulated to assess its effectiveness. Simulation results closely align with reality, showing a continuous decrease in susceptible individuals, a peak followed by a rapid decline in latent and infected individuals, and a steady increase in immune individuals. To control CWUB transmission, it is crucial to enhance immunity against unsafe behaviors, reduce the rate of immunity conversion, and shorten the disease cycle caused by such behaviors. This research has practical implications for construction projects.
Collaborative Filtering-Based Recommendation Systems for Touristic Businesses, Attractions, and Destinations
Authors: Aldayel Mashael , Al-Nafjan Abeer , Al-Nuwaiser Waleed M. , Alrehaili Ghadeer , Alyahya Ghadi
Published: September 2023

The success of touristic businesses, attractions, and destinations heavily relies on travel agents’ recommendations, which significantly impact client satisfaction. However, the underlying recommendation process employed by travel agents remains poorly understood. This study presents a conceptual model of the recommendation process and empirically investigates the influence of tourism categories on agents’ destination recommendations. By employing collaborative filtering-based recommendation systems and comparing various algorithms, including matrix factorization and deep learning models, such as the bilateral variational autoencoder (BiVAE) and light graph convolutional neural network, this research provides insights into the performance of different techniques in the context of tourism. The models were evaluated using a tourism dataset and assessed through a range of metrics. The results indicate that the BiVAE algorithm outperformed others in terms of ranking and prediction metrics, underscoring the significance of considering multiple measurements and exploring diverse techniques. The findings have practical implications for tourism marketers seeking to influence travel agents and offer valuable insights for researchers investigating this domain. Additionally, the proposed model holds potential for applications in travel recommendation systems, including attraction recommendations.
Resource Allocation of Multiple Base Stations for Throughput Enhancement in UAV Relay Networks
Authors: Han Sang
Published: September 2023

An unmanned aerial vehicle (UAV), with the advantages of mobility and easy deployment, serves as a relay node in wireless networks, which are known as UAV relay networks (URNs), to support user equipment that is out of service range (Uo) or does not have a direct communication link from/to the base station (BS) due to severe blockage. Furthermore, URNs have become crucial for delivering temporary communication services in emergency states or in disaster areas where the infrastructure is destroyed. The literature has explored single transmissions from one BS to a UAV to establish a wireless backhaul link in the URN; however, there exists a possibility of Uo outages due to severe interference from an adjacent BS, causing an overall throughput degradation of user equipment (UE) in the URN. In this paper, to improve the signal-to-interference-plus-noise ratio (SINR) of a wireless backhaul link, avoid an outage of Uo, and guarantee a reliable relay transmission, simultaneous transmissions from multiple BSs (e.g., macrocell BSs (mBSs) and small cell BSs (sBSs)) is considered. An outage probability is analyzed, and an optimal transmit time allocation algorithm is proposed to maximize the throughput of the UE and guarantee a reliable relay transmission. Simulation results demonstrate that simultaneous transmissions from multiple BSs in the URN leads to higher throughput and reliable transmission without an Uo outage compared to a single transmission in the URN from a single BS (e.g., mBS or sBS), and the optimization of transmit time allocation is essential in the URN.