bluuebunny/crossref_metadata_2025 huggingface dataset:
Progress of Edge-Emitting Diode Lasers Based on Coupled-Waveguide Concept
Authors: Han Lili , Wang Zhaowei , Gordeev Nikita Yu. , Maximov Mikhail V. , Tang Xiansheng , Beckman Artem A. , Kornyshov Grigoriy O. , Payusov Alexey S. , Shernyakov Yuri M. , Zhukov Alexey E. , Li Kuilong , Zhai Ruizhan , Jia Zhongqing , Yang He , Zhang Wei
Published: June 2023

Semiconductor lasers have developed rapidly with the steady growth of the global laser market. The use of semiconductor laser diodes is currently considered to be the most advanced option for achieving the optimal combination of efficiency, energy consumption, and cost parameters of high-power solid-state and fiber lasers. In this work, an approach for optical mode engineering in planar waveguides is investigated. The approach referred to as Coupled Large Optical Cavity (CLOC) is based on the resonant optical coupling between waveguides and allows the selection of high-order modes. The state-of-art of the CLOC operation is reviewed and discussed. We apply the CLOC concept in our waveguide design strategy. The results in both numerical simulation and experiment show that the CLOC approach can be considered a simple and cost-efficient solution for improving diode laser performance.
Optical Design of a Miniaturized 10× Periscope Zoom Lens for Smartphones
Authors: Sun Wen-Shing , Liu Yi-Hong , Tien Chuen-Lin
Published: June 2023

The size of the optical zoom system is important in smartphone camera design, especially as it governs the thickness of the smartphone. We present the optical design of a miniaturized 10× periscope zoom lens for smartphones. To achieve the desired level of miniaturization, the conventional zoom lens can be replaced with a periscope zoom lens. In addition to this change in the optical design, the quality of the optical glass, which also affects the performance of the lens, must be considered. With advancements in the optical glass manufacturing process, aspheric lenses are becoming more widely used. In this study, aspheric lenses are incorporated into a design for a 10× optical zoom lens with a lens thickness of less than 6.5 mm and an eight-megapixel image sensor. Furthermore, tolerance analysis is carried out to prove its manufacturability.
Prevalence and Characteristics of Novel Pathogenic Leptospira Species in Bats in Yunnan Province, China
Authors: Yang Tian , Yang Weihong , Kuang Guopeng , Pan Hong , Han Xi , Yang Lifen , Wang Juan , Feng Yun
Published: June 2023

Leptospirosis has been identified as a zoonotic disease caused by pathogenic spirochetes of the bacterial genus Leptospira. Rodents are considered the primary hosts of these bacteria, whereas many recent studies suggest that bats may serve as potential natural reservoirs. However, studies on pathogenic spirochetes hosted by bat populations still need to be completed in China. In this study, a total of 276 bats belonging to five genera collected in Yunnan Province (Southwest China) from 2017 to 2021 were included in the screening. Pathogenic spirochetes were detected by PCR amplification and sequencing targeting four genes (rrs, secY, flaB, and LipL32), resulting in 17 positive samples. Phylogenetic analysis based on multi-loci concatenated sequences, inferred by MLST approach, identified the strains as two novel Leptospira species within the pathogenic group. Of note, only Rousettus leschenaultii was found to harbor these spirochetes, suggesting it may be one of the potential natural reservoirs in circulating leptospires in this region. Nevertheless, the pathogenesis and transmission dynamics still need to be fully understood, requiring in-depth studies on other animals and the surrounding population.
The Effect of Oil-Rich Food Waste Substrates, Used as an Alternative Carbon Source, on the Cultivation of Microalgae—A Pilot Study
Authors: Sniegoňová Pavlína , Szotkowski Martin , Holub Jiří , Sikorová Pavlína , Márová Ivana
Published: June 2023

Microalgae are mostly phototrophic microorganisms present worldwide, showcasing great adaptability to their environment. They are known for producing essential metabolites such as carotenoids, chlorophylls, sterols, lipids, and many more. This study discusses the possibility of the mixotrophic abilities of microalgae in the presence of food waste oils. The utilization of food waste materials is becoming more popular as a research subject as its production grows every year, increasing the environmental burden. In this work, waste frying oil and coffee oil were tested for the first time as a nutrition source for microalgae cultivation. Waste frying oil is produced in large amounts all over the world and its simple purification is one of its greatest advantages as it only needs to be filtered from leftover food pieces. Coffee oil is extracted from waste spent coffee grounds as a by-product. The waste frying oil and coffee oil were added to the basic algal media as an alternative source of carbon. As a pilot study for further experimentation, the effect of oil in the medium, algal adaptability, and capability to survive were tested within these experiments. The growth and production characteristics of four algae and cyanobacteria strains were tested, of which the strain Desmodesmus armatus achieved exceptional results of chlorophyll (8.171 ± 0.475 mg/g) and ubiquinone (5.708 ± 0.138 mg/g) production. The strain Chlamydomonas reindhartii showed exceptional lipid accumulation in the range of 30–46% in most of the samples.
Comparative Genomic Analysis of ST131 Subclade C2 of ESBL-Producing E. coli Isolates from Patients with Recurrent and Sporadic Urinary Tract Infections
Authors: Jaén-Luchoro Daniel , Kahnamouei Arezou , Yazdanshenas Shora , Lindblom Anna , Samuelsson Emma , Åhrén Christina , Karami Nahid
Published: June 2023

The global emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli), mainly causing urinary tract infections (UTI), is a major threat to human health. ESBL-E. coli sequence type (ST) 131 is the dominating clone worldwide, especially its subclade C2. Patients developing recurrent UTI (RUTI) due to ST131 subclade C2 appear to have an increased risk of recurrent infections. We have thus compared the whole genome of ST131 subclade C2 isolates from 14 patients with RUTI to those from 14 patients with sporadic UTI (SUTI). We aimed to elucidate if isolates causing RUTI can be associated with specific genomic features. Paired isolates from patients with RUTI were identical, presenting 2-18 single nucleotide polymorphism (SNP) differences for all six patients investigated. Comparative genomic analyses, including virulence factors, antibiotic resistance, pangenome and SNP analyses did not find any pattern associated with isolates causing RUTI. Despite extensive whole genome analyses, an increased risk of recurrences seen in patients with UTI due to ST131 subclade C2 isolates could not be explained by bacterial genetic differences in the two groups of isolates. Hence, additional factors that could aid in identifying bacterial properties contributing to the increased risk of RUTI due to ESBL-E. coli ST131 subclade C2 remains to be explored.
Mid-Term Results of Single-Stage Surgery for Patients with Chronic Osteomyelitis Using Antibiotic-Loaded Resorbable PerOssal® Beads
Authors: Sambri Andrea , Cevolani Luca , Passarino Valentina , Bortoli Marta , Parisi Stefania Claudia , Fiore Michele , Campanacci Laura , Staals Eric , Donati Davide Maria , De Paolis Massimiliano
Published: June 2023

This retrospective study reports on the treatment of chronic osteomyelitis with local debridement combined with PerOssal®. The diagnosis of chronic osteomyelitis was confirmed in all cases and classified according to the Cierny–Mader (C-M) classification. The primary outcome was the eradication of infection at a minimum of one year after surgery. A total of 93 patients (median age: 40 years) were included. The most represented sites were the femur (24, 25.8%) and tibia (52, 55.9%). Twenty-six patients (28.0%) had significant local or systemic comorbidities (C-M Class B hosts). According to anatomic type, 31 cases were type I, 13 type II, 21 type III and 28 type IV. Vancomycin was added to PerOssal® in most cases (80, 86.0%). In 24 (25.8%) cases, Vancomycin and Rifampicin were combined. In 32 (34.4%) cases, intraoperative cultures were negative. Staphylococcus aureus was isolated in 39 (63.9%) patients, and Gram-negative bacteria were isolated in 12 cases. The median follow-up was 21 months (range 12–84). A total of 21 (22.6%) patients developed an infection recurrence (IR) after a median follow-up of 11 months (range: 1–47). PerOssal® holds several practical advantages compared to other bone void fillers. Thus, due to its good biocompatibility and sufficient antibiotic release, it represents a viable adjuvant treatment in chronic osteomyelitis.
Two Novel Neutral Cyclometalated Iridium(III) Complexes Based on 10,11,12,13-Tetrahydrodibenzo[a,c]phenazine for Efficient Red Electroluminescence
Authors: Yang Yuzhen , Zhao Han , Zhou Weiqiao , Zeng Qin , Zhang Zihao , Jiang Junjie , Gong Yongyang , Miao Yanqin , Guo Song , Liu Yuanli
Published: June 2023

Two novel neutral phosphorescent iridium(III) complexes (Ir1 and Ir2) were rationally designed and synthesized with high yields using 10,11,12,13-tetrahydrodibenzo[a,c]phenazine as the main ligand. The two complexes showed bright-red phosphorescence (625 nm for Ir1, and 620 nm for Ir2, in CH2Cl2), high-luminescence quantum efficiency (0.32 for Ir1, and 0.35 for Ir2), obvious solvatochromism and good thermostability. Then, they were used to fabricate high-efficiency red OLEDs via vacuum evaporation; the maximum current efficiency, power efficiency, and external quantum efficiency of the red devices based on Ir1 and Ir2 are 13.47/15.22 cd/A, 10.35/12.26 lm/W, and 10.08/7.48%, respectively.
Understanding Gel-Powers: Exploring Rheological Marvels of Acrylamide/Sodium Alginate Double-Network Hydrogels
Authors: Wang Shi-Chang , Du Shu-Tong , Hashmi Saud , Cui Shu-Ming , Li Ling , Handschuh-Wang Stephan , Zhou Xuechang , Stadler Florian J.
Published: June 2023

This study investigates the rheological properties of dual-network hydrogels based on acrylamide and sodium alginate under large deformations. The concentration of calcium ions affects the nonlinear behavior, and all gel samples exhibit strain hardening, shear thickening, and shear densification. The paper focuses on systematic variation of the alginate concentration—which serves as second network building blocks—and the Ca2+-concentration—which shows how strongly they are connected. The precursor solutions show a typical viscoelastic solution behavior depending on alginate content and pH. The gels are highly elastic solids with only relatively small viscoelastic components, i.e., their creep and creep recovery behavior are indicative of the solid state after only a very short time while the linear viscoelastic phase angles are very small. The onset of the nonlinear regime decreases significantly when closing the second network (alginate) upon adding Ca2+, while at the same time the nonlinearity parameters (Q0, I3/I1, S, T, e3/e1, and v3/v1) increase significantly. Further, the tensile properties are significantly improved by closing the alginate network by Ca2+ at intermediate concentrations.
Sesquiterpenoids from Meliaceae Family and Their Biological Activities
Authors: Riyadi Sandra Amalia , Naini Al Arofatus , Supratman Unang
Published: June 2023

Sesquiterpenoids, an important class of natural products possessing three isoprene-derived units, are widely distributed across plants and have a variety of biological activities. All sesquiterpenoids are derived from farnesyl pyrophosphate (FPP), a biosynthesis precursor that can form various carbon skeletons. In order to provide a reference for further research and development of these compounds, this review focused on the increasing number of isolated and volatile sesquiterpenoids found to be produced by plants of the Meliaceae family between 1968 and 2023. The related articles were collected from SciFinder, Google Scholar, and PubMed. According to a literature review, several studies were started for more than 55 years on the plant’s stem barks, twigs, leaves, flowers, seeds, and pericarps, where approximately 413 sesquiterpenoid compounds from several groups such as eudesmane, aromadendrane, cadinane, guaiane, bisabolane, furanoeremophilane, humulene, germacrane, and oppositane-type were isolated and identified with some minor products. Additionally, the hypothetical route of sesquiterpenoids biosynthesis from this family was identified, and eudesmane-type was reported to be 27% of the total compounds. The antimicrobial, antidiabetic, antioxidant, antiplasmodial, antiviral, and cytotoxic activities of the isolated compounds and major volatile sesquiterpenoids constituent on essential oil were also evaluated. The result showed the fundamental of using the sesquiterpenoid compounds from the Meliaceae family in traditional medicine and the discovery of new drugs.
Structured LDH/Bentonite Composites for Chromium Removal and Recovery from Aqueous Solutions
Authors: De Geest Mitra , Michielsen Bart , Ciocarlan Radu-G. , Cool Pegie , Seftel Elena M.
Published: June 2023

This study focuses on chromium removal through adsorption and ion exchange using structured calcined layered double hydroxide (LDH) (MgAl)–bentonite composites. Firstly, the powders were structured into granulates to study the effect on Cr sorption kinetics to circumvent the limitations of working with powders in real-life applications. Secondly, the regeneration of the structured composites was optimized to enable multi-cycling operation, which is the key for their applicability beyond laboratory scale. Firstly, the LDH/bentonite ratio was optimized to obtain the best performance for the removal of Cr3+ and Cr6+ species. In powder form, the calcined adsorbent containing 80 wt% LDH and 20 wt% bentonite performed best with an adsorption capacity of 48 and 40 mg/g for Cr3+ and Cr6+, respectively. The desorption was optimized by studying the effect of the NaCl concentration and pH, with a 2 M NaCl solution without pH modification being optimal. The kinetic data of the adsorption and desorption steps were modelled, revealing a pseudo-second order model for both. This was also demonstrated using XRD and Raman measurements after the Cr3+ and Cr6+ adsorption tests, indicating successful uptake and revealing the adsorption mechanism. Finally, five consecutive adsorption–desorption cycles were performed, each showing nearly 100% adsorption and desorption.
Differences in Volatile Organic Compounds in Rhizoma gastrodiae (Tian Ma) of Different Origins Determined by HS-GC-IMS
Authors: Duan Hao , Zhou Yaxi , Wang Diandian , Yan Wenjie
Published: June 2023

Headspace gas chromatography–ion mobility spectrometry (HS-GC-IMS) and principal component analysis (PCA) were used to compare the differences in volatile organic compounds (VOCs) of Rhizoma gastrodiae (Tian Ma) from six different origins in Yunnan, Sichuan, Shaanxi, Anhui, Hubei, and Guizhou. A total of 161 signal peaks were identified, and 84 compounds were characterized, including 23 aldehydes, 19 alcohols, 12 ketones, 8 heterocyclic compounds, 7 esters, 4 phenols, 4 acids, 4 ethers, 2 amines, and 1 alkane. The results of cluster analysis and fingerprint similarity analysis based on principal component analysis and Euclidean distance indicated that there were significant differences between the volatile components of Rhizoma gastrodiae from different origins. This study demonstrated that HS-GC-IMS is simple, rapid, accurate, and has a small sample size and can achieve rapid analysis of the differences in volatile compounds between samples of different origins of Rhizoma gastrodiae.
In Silico Identification of Natural Product-Based Inhibitors Targeting IL-1β/IL-1R Protein–Protein Interface
Authors: Liu Ting-ting , Chen Yan-kun , Adil Muhammad , Almehmadi Mazen , Alshabrmi Fahad M. , Allahyani Mamdouh , Alsaiari Ahad Amer , Liu Pei , Khan Muhammad Raheel , Peng Qinghua
Published: June 2023

IL-1β mediates inflammation and regulates immune responses, cell proliferation, and differentiation. Dysregulation of IL-1β is linked to inflammatory and autoimmune diseases. Elevated IL-1β levels are found in patients with severe COVID-19, indicating its excessive production may worsen the disease. Also, dry eye disease patients show high IL-1β levels in tears and conjunctival epithelium. Therefore, IL-1β signaling is a potential therapeutic targeting for COVID-19 and aforementioned diseases. No small-molecule IL-1β inhibitor is clinically approved despite efforts. Developing such inhibitors is highly desirable. Herein, a docking-based strategy was used to screen the TCM (Traditional Chinese Medicine) database to identify possible IL-1β inhibitors with desirable pharmacological characteristics by targeting the IL-1β/IL-1R interface. Primarily, the docking-based screening was performed by selecting the crucial residues of IL-1β interface to retrieve the potential compounds. Afterwards, the compounds were shortlisted on the basis of binding scores and significant interactions with the crucial residues of IL-1β. Further, to gain insights into the dynamic behavior of the protein–ligand interactions, MD simulations were performed. The analysis suggests that four selected compounds were stabilized in an IL-1β pocket, possibly blocking the formation of an IL-1β/IL-1R complex. This indicates their potential to interfere with the immune response, making them potential therapeutic agents to investigate further.
Molecular Taphonomy of Heme: Chemical Degradation of Hemin under Presumed Fossilization Conditions
Authors: Tahoun Mariam , Engeser Marianne , Svolacchia Luca , Sander Paul Martin , Müller Christa E.
Published: June 2023

The metalloporphyrin heme acts as the oxygen-complexing prosthetic group of hemoglobin in blood. Heme has been noted to survive for many millions of years in fossils. Here, we investigate its stability and degradation under various conditions expected to occur during fossilization. Oxidative, reductive, aerobic, and anaerobic conditions were studied at neutral and alkaline pH values. Elevated temperatures were applied to accelerate degradation. High-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) identified four main degradation products. The vinyl residues are oxidized to formyl and further to carboxylate groups. In the presence of air or H2O2, cleavage of the tetrapyrrole ring occurs, and hematinic acid is formed. The highest stability of heme was observed under anaerobic reductive conditions (half-life 9.5 days), while the lowest stability was found in the presence of H2O2 (half-life 1 min). We confirmed that the iron cation plays a crucial role in degradation, since protoporphyrin IX, lacking iron, remained significantly more stable. Under anaerobic, reductive conditions, the above-mentioned degradation products were not observed, suggesting a different degradation pathway. To our knowledge, this is the first molecular taphonomy study on heme, which will be useful for understanding its fate during fossilization.
Polarization Splitting at Visible Wavelengths with the Rutile TiO2 Ridge Waveguide
Authors: Zheng Xinzhi , Ma Yujie , Zhao Chenxi , Xiang Bingxi , Yu Mingyang , Dai Yanmeng , Xu Fang , Lv Jinman , Lu Fei , Zhou Cangtao , Ruan Shuangchen
Published: June 2023

On-chip polarization control is in high demand for novel integrated photonic applications such as polarization division multiplexing and quantum communications. However, due to the sensitive scaling of the device dimension with wavelength and the visible-light absorption properties, traditional passive silicon photonic devices with asymmetric waveguide structures cannot achieve polarization control at visible wavelengths. In this paper, a new polarization-splitting mechanism based on energy distributions of the fundamental polarized modes in the r-TiO2 ridge waveguide is investigated. The bending loss for different bending radii and the optical coupling properties of the fundamental modes in different r-TiO2 ridge waveguide configurations are analyzed. In particular, a polarization splitter with a high extinction ratio operating at visible wavelengths based on directional couplers (DCs) in the r-TiO2 ridge waveguide is proposed. Polarization-selective filters based on micro-ring resonators (MRRs) with resonances of only TE or TM polarizations are designed and operated. Our results show that polarization-splitters for visible wavelengths with a high extinction ratio in DC or MRR configurations can be achieved with a simple r-TiO2 ridge waveguide structure.
Superior High Transistor’s Effective Mobility of 325 cm2/V-s by 5 nm Quasi-Two-Dimensional SnON nFET
Authors: Pooja Pheiroijam , Chien Chun Che , Chin Albert
Published: June 2023

This work reports the first nanocrystalline SnON (7.6% nitrogen content) nanosheet n-type Field-Effect Transistor (nFET) with the transistor’s effective mobility (µeff) as high as 357 and 325 cm2/V-s at electron density (Qe) of 5 × 1012 cm−2 and an ultra-thin body thickness (Tbody) of 7 nm and 5 nm, respectively. At the same Tbody and Qe, these µeff values are significantly higher than those of single-crystalline Si, InGaAs, thin-body Si-on-Insulator (SOI), two-dimensional (2D) MoS2 and WS2. The new discovery of a slower µeff decay rate at high Qe than that of the SiO2/bulk-Si universal curve was found, owing to a one order of magnitude lower effective field (Eeff) by more than 10 times higher dielectric constant (κ) in the channel material, which keeps the electron wave-function away from the gate-oxide/semiconductor interface and lowers the gate-oxide surface scattering. In addition, the high µeff is also due to the overlapped large radius s-orbitals, low 0.29 mo effective mass (me*) and low polar optical phonon scattering. SnON nFETs with record-breaking µeff and quasi-2D thickness enable a potential monolithic three-dimensional (3D) integrated circuit (IC) and embedded memory for 3D biological brain-mimicking structures.
Comparison of the Potential Relative Bioaccessibility of Zinc Supplements—In Vitro Studies
Authors: Ośko Justyna , Pierlejewska Wiktoria , Grembecka Małgorzata
Published: June 2023

The aim of this study was to determine the potential relative bioaccessibility of zinc (Zn) from selected dietary supplements during in vitro digestion. The bioaccessibility of Zn was evaluated in dietary supplements differing in the pharmaceutical form, content, dose, and chemical form of the element. The content of Zn was determined by flame atomic absorption spectrometry. The applied method was validated, and results were characterised by good linearity (R2 = 0.998), recovery (109%), and accuracy (0.02%). As a result of the tests conducted, it was found that the bioaccessibility of Zn from dietary supplements varied and ranged from 1.1% to 9.4%. The highest bioaccessibility was found for zinc diglycinate and the lowest for zinc sulphate. In 9 out of 10 tested dietary supplements, the determined Zn content was higher than the one declared by the producer (up to 161%). The estimated tolerable upper intake level (UL) was exceeded by five of the analysed dietary supplements (123–146%). The analysed dietary supplements were assessed in terms of compliance with the information contained on the product packaging, based on current Polish and European legal regulations. The qualitative assessment was performed according to the United States Pharmacopoeia (USP) guidelines.
Dietary Patterns Associated with Abnormal Glucose Tolerance following Gestational Diabetes Mellitus: The MyNutritype Study
Authors: Hasbullah Farah Yasmin , Mohd Yusof Barakatun-Nisak , Shyam Sangeetha , Abdul Ghani Rohana , Mohamed Khir Hannah Izzati
Published: June 2023

Abnormal glucose tolerance (AGT), which includes type 2 diabetes and pre-diabetes, is highly prevalent in women post gestational diabetes mellitus (post-GDM). Dietary patterns have been associated with the risk of developing AGT in women post-GDM, but evidence in Asian populations is sparse. This study aimed to determine the association between a posteriori dietary patterns and AGT in women post-GDM. This cross-sectional study recruited 157 women post-GDM (mean age 34.8 years) from Seri Kembangan Health Clinic and Universiti Putra Malaysia. AGT was diagnosed according to the Malaysian Clinical Practice Guidelines using a 75 g 2 h oral glucose tolerance test or HbA1c. Food intake was assessed using the 2014 Malaysian Adult Nutrition Survey food frequency questionnaire. Five dietary patterns were derived using principal component analysis: ‘Unhealthy’, ‘Fish-eggs-fruits-vegetables’, ‘Cereals-confectionaries’, ‘Legumes-dairy’, and ‘Meat-sugar-sweetened-beverages’. After adjusting for sociodemographic characteristics and total energy intake, the ‘Cereals-confectionaries’ dietary pattern was significantly associated with AGT (adjusted odds ratio 1.536, p = 0.049). Targeted lifestyle modification, including dietary intervention, for women post-GDM is warranted to reduce their risk of AGT and its complications.
Disrupting the Dok3–Card9 Interaction with Synthetic Peptides Enhances Antifungal Effector Functions of Human Neutrophils
Authors: Loh Jia Tong , Teo Joey Kay Hui , Kannan Srinivasaraghavan , Verma Chandra S. , Lim Hong-Hwa , Lam Kong-Peng
Published: June 2023

Invasive fungal disease is an emerging and serious public health threat globally. The expanding population of susceptible individuals, together with the rapid emergence of multidrug-resistant fungi pathogens, call for the development of novel therapeutic strategies beyond the limited repertoire of licensed antifungal drugs. Card9 is a critical signaling molecule involved in antifungal defense; we have previously identified Dok3 to be a key negative regulator of Card9 activity in neutrophils. In this study, we identified two synthetic peptides derived from the coiled-coil domain of Card9, which can specifically block Dok3–Card9 binding. We showed that these peptides are cell-permeable, non-toxic, and can enhance antifungal cytokine production and the phagocytosis of human neutrophils upon fungal infection. Collectively, these data provide a proof of concept that disrupting the Dok3–Card9 interaction can boost the antifungal effector functions of neutrophils; they further suggest the potential utility of these peptide inhibitors as an immune-based therapeutic to fight fungal infection.
Application of Silver Nanoparticles in Parasite Treatment
Authors: Zhang Ping , Gong Jiahao , Jiang Yan , Long Yunfeng , Lei Weiqiang , Gao Xiuge , Guo Dawei
Published: June 2023

Silver nanoparticles (AgNPs) are ultra-small silver particles with a size from 1 to 100 nanometers. Unlike bulk silver, they have unique physical and chemical properties. Numerous studies have shown that AgNPs have beneficial biological effects on various diseases, including antibacterial, anti-inflammatory, antioxidant, antiparasitic, and antiviruses. One of the most well-known applications is in the field of antibacterial applications, where AgNPs have strong abilities to kill multi-drug resistant bacteria, making them a potential candidate as an antibacterial drug. Recently, AgNPs synthesized from plant extracts have exhibited outstanding antiparasitic effects, with a shorter duration of use and enhanced ability to inhibit parasite multiplication compared to traditional antiparasitic drugs. This review summarizes the types, characteristics, and the mechanism of action of AgNPs in anti-parasitism, mainly focusing on their effects in leishmaniasis, flukes, cryptosporidiosis, toxoplasmosis, Haemonchus, Blastocystis hominis, and Strongylides. The aim is to provide a reference for the application of AgNPs in the prevention and control of parasitic diseases.
A Concise Review of the Progress in Photonic Sensing Devices
Authors: Shahbaz Muhammad , Butt Muhammad A. , Piramidowicz Ryszard
Published: June 2023

Photonic sensing devices have become increasingly important in various fields such as agriculture, medicine, biochemical sensing, and manufacturing. They are highly sensitive and can classify minor changes in the physical and chemical properties of the ambient medium with high precision. This makes them practical in applications where accurate measurements are critical, such as medical diagnostics and environmental monitoring. In this review paper, recent advances in different types of photonic sensors are discussed, which include photonic crystal-based sensors, surface plasmon resonance-based sensors, optical fiber-based sensors, optical waveguide-based sensors, and wearable sensors. These highly fascinating sensing devices play a crucial role in countless applications and have several advantages over traditional sensors. As technology continues to advance, we can expect photonic sensors to become even more precise, versatile, and reliable.
Terahertz Bessel Beams Formed by Binary and Holographic Axicons
Authors: Knyazev Boris , Osintseva Natalya , Komlenok Maxim , Pavelyev Vladimir , Gerasimov Vasily , Kameshkov Oleg , Choporova Yulia , Tukmakov Konstantin
Published: June 2023

The characteristics of high-power vortex Bessel beams in the terahertz range (λ=141 μm) obtained with the use of diffractive axicons (DAs) illuminated by a Gaussian beam of the Novosibirsk free-electron laser were studied. Two of the three possible types of DA recently described in our previous paper, namely, binary spiral silicon axicons (BAs), forming beams with a topological charge l equal to 0–4 and 9, and a diamond “holographic” axicon (HA), forming a beam with l=9, were used in the experiments. These axicons formed beams whose cross sections in the region of inner Bessel rings were close to those of ideal Bessel beams, but their intensities varied in azimuth with a frequency of l and 2l for the BAs and HA, respectively. However, in the case of the BAs, the beams had a pronounced helical structure at the periphery, whereas for the HA, the beam was axisymmetric. By focusing these beams with a lens, we studied the structure of the so-called “perfect” beams (PBs). While an ideal Bessel beam exhibits a PB as a thin ring, in the case of the BAs, we observed a broadened ring structure consisting of 2l short spirals, and for the HA, we observed a narrow ring with 2l maxima in azimuth. A comparison of the numerical calculations and experiments showed that the observed azimuthal intensity variations can be attributed to inaccuracies in the preparation of the axicon relief and/or discrepancies between the calculated and actual wavelengths, within a few percent. The results of this work enable the establishment of quality requirements for axicon manufacture and the appropriate selection of the axicon type in accordance with the requirements for the beam.
The Spatiotemporal Dynamics of Electron Plasma in Femtosecond Laser Double Pulses Induced Damage in Fused Silica
Authors: Shen Tianlun , Si Jinhai , Tian Dongpo , Chen Tao , Li Peng , Hou Xun
Published: June 2023

In this study, we employed the fs time-resolved shadowgraphy method to investigate the impact of the first pump pulse (DP1) on the transient temporal and spatial evolution of electron plasma induced by femtosecond (fs) laser double pulses (DPs) in fused silica. It was observed that the DP1-induced phase transition acted as a waveguide, confining the propagation of the second pump pulse (DP2) light inside the material and resulting in a decrease in the diameter of the DP2-induced electron plasma region. Moreover, the DP2-induced maximum peak electron density was higher than that induced by a single pulse (SP) at the same pulse energy, which may be explained by the DP1-induced highly absorbing semi-metallic state of warm dense glass in fused silica. Importantly, as the energy of DP1 increased, the mean diameter of the DP2-induced electron plasma region further decreased, and the maximum peak electron density increased. Compared with SPs, DPs more easily produced damage in fused silica. In addition, the mean diameter of the DP2-induced electron plasma region and the maximum peak electron density remained almost unchanged when the pulses’ time separation (ts) was changed from 1 to 50 ps, mainly due to the long relaxation time of the phase transition caused by DP1.
Segmented Four-Element Photodiodes in a Three-Dimensional Laser Beam Angle Measurement
Authors: Konov Stanislav , Frolov Aleksander , Shapovalov Petr , Peretyagin Pavel , Grigoriev Sergey
Published: June 2023

Based on the registration of two laser beam projections, a method for measuring the angular deviation of a laser beam from its initial position in three-dimensional space is proposed and experimentally demonstrated. The laser ray is directed into the beam-splitting cube, which distributes the ray into two mutually orthogonal parts, on the path of which, two four-segment photodiodes are located at different distances from the beam-splitting cube. The value of the angular deviation from a certain initial position of the laser beam in three-dimensional space is obtained after the mathematical processing of the measured position of the laser beam projections’ centers in the photodiodes coordinates systems. The innovation of this method is that the resulting angular deviation of the laser beam is in three-dimensional space due to the registration of a pair of projections. The experimental results also demonstrate that the proposed method has a high speed-measuring potential and can be used for solving a wide range of problems.
Abelmoschus eculentus Seed Extract Exhibits In Vitro and In Vivo Anti-Alzheimer’s Potential Supported by Metabolomic and Computational Investigation
Authors: Bakhsh Hussain T. , Mokhtar Fatma A. , Elmaidomy Abeer H. , Aly Hanan F. , Younis Eman A. , Alzubaidi Mubarak A. , Altemani Faisal H. , Algehainy Naseh A. , Majrashi Mohammed Ali A. , Alsenani Faisal , Bringmann Gerhard , Abdelmohsen Usama Ramadan , Abdelhafez Omnia Hesham
Published: June 2023

Abelmoschus esculentus Linn. (okra, F. Malvaceae) is a fruit widely consumed all over the world. In our study, the anti-Alzheimer’s potential of A. esculentus was evaluated. An in vitro DPPH free radical assay on A. esculentus seed’s total extract and AChE inhibition potential screening indicated a significant anti-Alzheimer’s activity of the extract, which was confirmed through an in vivo study in an aluminum-intoxicated rat model. Additionally, in vivo results demonstrated significant improvement in Alzheimer’s rats, which was confirmed by improving T-maze, beam balance tests, lower serum levels of AChE, norepinephrine, glycated end products, IL-6, and MDA. The levels of dopamine, BDNF, GSH, and TAC returned to normal values during the study. Moreover, histological investigations of brain tissue revealed that the destruction in collagen fiber nearly returns back to the normal pattern. Metabolomic analysis of the ethanolic extract of A. esculentus seeds via LC–HR-ESI-MS dereplicated ten compounds. A network pharmacology study displayed the relation between identified compounds and 136 genes, among which 84 genes related to Alzheimer’s disorders, and focused on AChE, APP, BACE1, MAPT and TNF genes with interactions to all Alzheimer’s disorders. Consequently, the results revealed in our study grant potential dietary elements for the management of Alzheimer’s disorders.
Receptor for Activated C Kinase1B (RACK1B) Delays Salinity-Induced Senescence in Rice Leaves by Regulating Chlorophyll Degradation
Authors: Rahman Md Ahasanur , Ullah Hemayet
Published: June 2023

The widely conserved Receptor for Activated C Kinase1 (RACK1) protein is a WD-40 type scaffold protein that regulates diverse environmental stress signal transduction pathways. Arabidopsis RACK1A has been reported to interact with various proteins in salt stress and Light-Harvesting Complex (LHC) pathways. However, the mechanism of how RACK1 contributes to the photosystem and chlorophyll metabolism in stress conditions remains elusive. In this study, using T-DNA-mediated activation tagging transgenic rice (Oryza sativa L.) lines, we show that leaves from rice RACK1B gene (OsRACK1B) gain-of-function (RACK1B-OX) plants exhibit the stay-green phenotype under salinity stress. In contrast, leaves from down-regulated OsRACK1B (RACK1B-UX) plants display an accelerated yellowing. qRT-PCR analysis revealed that several genes which encode chlorophyll catabolic enzymes (CCEs) are differentially expressed in both RACK1B-OX and RACK1B-UX rice plants. In addition to CCEs, stay-green (SGR) is a key component that forms the SGR-CCE complex in senescing chloroplasts, and which causes LHCII complex instability. Transcript and protein profiling revealed a significant upregulation of OsSGR in RACK1B-UX plants compared to that in RACK1B-OX rice plants during salt treatment. The results imply that senescence-associated transcription factors (TFs) are altered following altered OsRACK1B expression, indicating a transcriptional reprogramming by OsRACK1B and a novel regulatory mechanism involving the OsRACK1B-OsSGR-TFs complex. Our findings suggest that the ectopic expression of OsRACK1B negatively regulates chlorophyll degradation, leads to a steady level of LHC-II isoform Lhcb1, an essential prerequisite for the state transition of photosynthesis for adaptation, and delays salinity-induced senescence. Taken together, these results provide important insights into the molecular mechanisms of salinity-induced senescence, which can be useful in circumventing the effect of salt on photosynthesis and in reducing the yield penalty of important cereal crops, such as rice, in global climate change conditions.
Teratogen Potential Evaluation of the Aqueous and Hydroalcoholic Leaf Extracts of Crataegus oxyacantha in Pregnancy Rats
Authors: Aguilera-Rodríguez Fany Renata , Zamora-Perez Ana Lourdes , Gutiérrez-Hernández Rosalinda , Quirarte-Báez Sol María , Reyes Estrada Claudia Araceli , Ortiz-García Yveth Marlene , Lazalde-Ramos Blanca Patricia
Published: June 2023

Crataegus oxyacantha is used in the treatment of cardiovascular diseases. The aim of this study was to evaluate the transplacental genotoxicity effect of aqueous (AE) and hydroalcoholic extract (HE) of leaves C. oxyacantha in a rat model and the quantification of malondialdehyde (MDA) in the liver. Three different doses of the AE and HE of the C. oxyacantha leaf were administered orally (500, 1000 and 2000 mg/kg) to Wistar rats during 5 days through the pregnancy term (16–21 days), and sampling in rats occurred every 24 h during the last 6 days of gestation, while only one sample was taken in neonates at birth. A sample of the mother’s and the neonate’s liver was taken for the determination of MDA. The results show that, at the hepatic level, the evaluated doses of extracts C. oxyacantha in pregnant rats and their pups did not show cytotoxicity. However, the AE and HE generated cytotoxic and genotoxic damage in the short term. On the other hand, only the AE showed a teratogenic effect. Based on these results, the AE and HE of the C. oxyacantha leaf should not be administered during pregnancy.
Effect of Calcium Foliar Spray Technique on Mechanical Properties of Strawberries
Authors: Cieniawska Beata , Komarnicki Piotr , Samelski Maciej , Barć Marek
Published: June 2023

The calcium fertilization of strawberry plants (Fragaria × ananassa Duchesne) was evaluated using two types of nozzles, with two liquid pressure levels and two driving speeds. The calcium content of the leaves and fruit were analyzed via flame photometry. Higher leaf calcium content was found in plots sprayed with standard nozzles, while higher fruit calcium content was observed for those sprayed with air induction nozzles. The fruit quality was assessed by determining the basic physical and mechanical properties, using uniaxial compression tests integrated with surface pressure measurements. Different spraying techniques influenced the mechanical resistance of the fruit. A spraying speed of 5 km/h and an operating pressure of 0.4 MPa significantly increased the firmness of the fruit by ~66%, the critical load level by 36%, and the maximum surface pressure by up to 38%, but did not increase the geometrical parameters of the strawberries. Regular foliar feeding during harvest could improve the mechanical strength of strawberries. An appropriate spraying technique with a calcium agent could effectively improve the mechanical properties of the delicate fruit, which is particularly important for limiting losses during harvesting, transportation, and storage.
Cytotoxic Properties of Polyurethane Foams for Biomedical Applications as a Function of Isocyanate Index
Authors: Grzęda Dominik , Węgrzyk Grzegorz , Nowak Adriana , Idaszek Joanna , Szczepkowski Leonard , Ryszkowska Joanna
Published: June 2023

Polyurethane foams are widely used in biomedical applications due to their desirable mechanical properties and biocompatibility. However, the cytotoxicity of its raw materials can limit their use in certain applications. In this study, a group of open-cell polyurethane foams were investigated for their cytotoxic properties as a function of the isocyanate index, a critical parameter in the synthesis of polyurethanes. The foams were synthesized using a variety of isocyanate indices and characterized for their chemical structure and cytotoxicity. This study indicates that the isocyanate index highly influences the chemical structure of polyurethane foams, also causing changes in cytotoxicity. These findings have important implications for designing and using polyurethane foams as composite matrices in biomedical applications, as careful consideration of the isocyanate index is necessary to ensure biocompatibility.
Comparison of Alginate Mixtures as Wall Materials of Schizochytrium Oil Microcapsules Formed by Coaxial Electrospray
Authors: Arevalo-Gallegos Alejandra , Cuellar-Bermudez Sara P. , Melchor-Martinez Elda M. , Iqbal Hafiz M. N. , Parra-Saldivar Roberto
Published: June 2023

This work evaluated maltodextrin/alginate and β-glucan/alginate mixtures in the food industry as wall materials for the microencapsulation of Schizochytrium sp. oil, an important source of the omega-3 fatty acid DHA (docosahexaenoic acid). Results showed that both mixtures display a shear-thinning behavior, although the viscosity is higher in β-glucan/alginate mixtures than in maltodextrin/alginate. Scanning electron microscopy was used to assess the morphology of the microcapsules, which appeared more homogeneous for maltodextrin/alginate. In addition, oil-encapsulation efficiency was higher in maltodextrin/alginate mixtures (90%) than in β-glucan/alginate mixtures (80%). Finally, evaluating the microcapsules’ stability by FTIR when exposed to high temperature (80 °C) showed that maltodextrin/alginate microcapsules were not degraded contrary to the β-glucan/alginate microcapsules. Thus, although high oil-encapsulation efficiency was obtained with both mixtures, the microcapsules’ morphology and prolonged stability suggest that maltodextrin/alginate is a suitable wall material for microencapsulation of Schizochytrium sp. oil.
A Feasibility Study on the Use of Injection Molding Systems for Mass Production of 100W Class Wind Turbine Blades
Authors: Kim Joongseon , Tuladhar Upendra , Je Deokkeun , Mieremet Marinus , Baek Joonho , Ji Hoseong , Ahn Seokyoung
Published: June 2023

A feasibility study on the mass production of a small wind turbine blade using an injection molding process was conducted. The blade was divided into three sections suitable for injection molding, and the mold was designed and analyzed using Moldflow CAE S/W. The optimal feedstock material was selected through comparison and analysis of three candidate materials. A mold was manufactured to test the injection molding process and evaluate related parameters. The resulting blade was assembled with other components, and a generator was installed to assess its durability, safety, and performance under various conditions. The results indicated the feasibility of producing a blade for a small wind turbine through injection molding, which predicted higher productivity and lower costs compared to traditional manufacturing methods that rely heavily on manual labor.
Novel Copper Oxide Phyto-Nanocatalyst Utilized for the Synthesis of Sustainable Biodiesel from Citrullus colocynthis Seed Oil
Authors: Aziz Aqsa , Ahmad Mushtaq , Zafar Muhammad , Gaafar Abdel-Rhman Z. , Hodhod Mohamed S. , Sultana Shazia , Athar Mohammad , Ozdemir Fethi Ahmet , Makhkamov Trobjon , Yuldashev Akramjon , Mamarakhimov Oybek , Nizomova Maxsuda , Majeed Salman , Chaudhay Bisha
Published: June 2023

The green chemistry method for nanocatalyst synthesis along with environmentally feasible non-edible sources are promising alternatives to fossil fuels. The current study focuses on the synthesis of copper oxide phyto-nanocatalyst and the identification of a new renewable feedstock, Citrullus colocynthis, to reduce environmental pollution. The highest biodiesel yield (95%) was obtained under optimum conditions of a 1:8 oil-to-methanol ratio and reaction temperature of 85 °C for 120 min with a 0.365 wt% catalyst concentration. The phyto-nanocatalyst was synthesized using seed oil cake after extracting oil with the salt of copper (copper oxide). The catalyst was then subjected to various analyses, namely, EDX, FT-IR, SEM, and XRD. The catalyst was proved to be efficient and effective after being reused five times and still there was a very small difference in biodiesel yield. All the analyses also show sustainable and stable results. Thus, copper oxide phyto-nanocatalyst with non-edible Citrullus colocynthis proved to be highly effective, sustainable, and a better alternative source to the future biodiesel industry.
Observer-Based Control of Inductive Wireless Power Transfer System Using Genetic Algorithm
Authors: Abdelrahim Mahmoud , Almakhles Dhafer
Published: June 2023

In this paper, we studied the feedback stabilization of an inductive power transfer system based on available output measurement. The proposed controller relies on a full-order state observer in order to estimate the unmeasured state. The control design problem is challenging due to the large dimension of the closed-loop system, which requires too many tuning parameters to be determined when conventional control methods are employed. To solve this issue, we propose an LQR methodology based on a genetic algorithm such that the weighing coefficients of the cost function matrices can be automatically computed in an optimized manner. The proposed approach combines the method of eigenstructure assignment and the LQR technique in order to design both the controller and the observer gain matrices. The design methodology provides a systematic way to compute the parameters of the LQR technique for a wireless power transfer system in an optimized manner, which can be a useful design tool for many other applications. The effectiveness of the approach was verified by numerical simulation on the dynamic model of the wireless power transfer system. The results show that the proposed design outperforms conventional design methods in terms of a better performance and reduced design iterations effort.