bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Understanding of the Pathogenesis of Dengue Virus Infection
Authors: Bhatt Puneet , Sabeena Sasidharan Pillai , Varma Muralidhar , Arunkumar Govindakarnavar
Published: November 2020

The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein and anti-DENV NS1 antibodies were believed to be responsible for pathogenesis of severe dengue. The cytokine response of cross-reactive CD4+ T cells might be altered by the sequential infection with different DENV serotypes, leading to further elevation of pro-inflammatory cytokines contributing a detrimental immune response. Fcγ receptor-mediated antibody-dependent enhancement (ADE) results in release of cytokines from immune cells leading to vascular endothelial cell dysfunction and increased vascular permeability. Genomic variation of dengue virus and subgenomic flavivirus RNA (sfRNA) suppressing host immune response are viral determinants of disease severity. Dengue infection can lead to the generation of autoantibodies against DENV NS1antigen, DENV prM, and E proteins, which can cross-react with several self-antigens such as plasminogen, integrin, and platelet cells. Apart from viral factors, several host genetic factors and gene polymorphisms also have a role to play in pathogenesis of DENV infection. This review article highlights the various factors responsible for the pathogenesis of dengue and also highlights the recent advances in the field related to biomarkers which can be used in future for predicting severe disease outcome.
On the role of large cross-sectional deformations in the nonlinear analysis of composite thin-walled structures
Authors: Carrera E. , Pagani A. , Augello R.
Published: November 2020

The geometrical nonlinear effects caused by large displacements and rotations over the cross section of composite thin-walled structures are investigated in this work. The geometrical nonlinear equations are solved within the finite element method framework, adopting the Newton–Raphson scheme and an arc-length method. Inherently, to investigate cross-sectional nonlinear kinematics, low- to higher-order theories are employed by using the Carrera unified formulation, which provides a tool to generate refined theories of structures in a systematic manner. In particular, beams and shell-like laminated composite structures are analyzed using a layerwise approach, according to which each layer has its own independent kinematics. Different stacking sequences are analyzed, to highlight the influence of the cross-ply angle on the static responses. The results show that the geometrical nonlinear effects play a crucial role, mainly when higher-order theories are utilized.
Nutritional jejunostomy in esophagectomy for cancer, a national register-based cohort study of associations with postoperative outcomes and survival
Authors: Holmén Anders , Hayami Masaru , Szabo Eva , Rouvelas Ioannis , Agustsson Thorhallur , Klevebro Fredrik
Published: November 2020

Purpose

Insertion of a nutritional jejunostomy in conjunction with esophagectomy is performed with the intention to decrease the risk for postoperative malnutrition and improve recovery without adding significant catheter-related complications. However, previous research has shown no clear benefit and there is currently no consensus of practice.

Methods

All patients treated with esophagectomy due to cancer during the period 2006–2017 reported in the Swedish National Register for Esophageal and Gastric Cancer were included in this register-based cohort study from a national database. Patients were stratified into two groups: esophagectomy alone and esophagectomy with jejunostomy.

Results

A total of 847 patients (45.27%) had no jejunostomy inserted while 1024 patients (54.73%) were treated with jejunostomy. The groups were comparable, but some differences were seen in histological tumor type and tumor stage between the groups. No significant differences in length of hospital stay, postoperative surgical complications, Clavien-Dindo score, or 90-day mortality rate were seen. There was no evidence of increased risk for significant jejunostomy-related complications. Patients in the jejunostomy group with anastomotic leaks had a statistically significant lower risk for severe morbidity defined as Clavien-Dindo score ≥ IIIb (adjusted odds ratio 0.19, 95% CI: 0.04–0.94, P = 0.041) compared to patients with anastomotic leaks and no jejunostomy.

Conclusion

A nutritional jejunostomy is a safe method for early postoperative enteral nutrition which might decrease the risk for severe outcomes in patients with anastomotic leaks. Nutritional jejunostomy should be considered for patients undergoing curative intended surgery for esophageal and gastro-esophageal junction cancer.
Vom Elfenbeinturm auf die Straße und zurück – Kompass für ein solidarisches Quartier
Authors: Hellriegel Maximilian , Schmitt Pacífico Sara
Published: November 2020

Vor dem Hintergrund der zunehmenden Veränderung des städtischen Lebensumfeldes durch Gentrifizierung, investorenfreundliche Stadtpolitik, Privatisierung öffentlicher Räume, Einsparung öffentlicher Investitionen und den Abbau demokratischer Beteiligungsinstrumente haben wir uns gefragt: Wie könnte eine solidarische Stadt der Zukunft aussehen? Welche Gegenentwürfe zu aktuell herrschenden Paradigmen in der Stadtentwicklung zeigen uns Wege aus der Alternativlosigkeit hin zu einer solidarischen Praxis auf Quartiersebene? Im Rahmen einer angewandten kritischen Geografie möchten wir zeigen, dass es eine Vielzahl an Projekten und Initiativen gibt, die die Kreativlosigkeit, zu der uns der Neoliberalismus erzogen hat, durchbrechen und an konkreten Ideen und deren praktischer Umsetzung arbeiten. Als theoretische Annäherung dafür setzen wir uns mit Utopien und deren Potenzialen für eine politische Praxis auseinander. Da wir selbst im Kontext stadtpolitischer Gruppen engagiert sind, nutzen wir die aktivistische Stadtforschung als methodischen Rahmen unserer Forschung. Daraus entstanden ist ein Faltblatt, der „Kompass für ein solidarisches Quartier“, welcher als aktivistisches Werkzeug und Ideengeber für die konkrete Umsetzung transformativer Stadtpolitik dienen soll.
Sexual preference for prepubescent children is associated with enhanced processing of child faces in juveniles
Authors: Speer Lara , Schuler Miriam , Keil Julian , Moran James K. , Pantazidis Pierre , Amelung Till , Florack Jakob , Beier Klaus M. , Senkowski Daniel
Published: November 2020

Child sexual abuse offences (CSOs) represent a severe ethical and socioeconomic burden for society. Juveniles with a sexual preference for prepubescent children (PP) commit a large percentage of CSOs, but have been widely neglected in neuroscience research. Aberrant neural responses to face stimuli have been observed in men with pedophilic interest. Thus far, it is unknown whether such aberrations exist already in PP. A passive face-viewing paradigm, including the presentation of child and adult faces, was deployed and high-density electroencephalography data were recorded. The study group comprised 25 PP and the control group involved 22 juveniles with age-adequate sexual preference. Attractiveness ratings and evoked brain responses were obtained for the face stimuli. An aberrant pattern of attractiveness ratings for child vs. adult faces was found in the PP group. Moreover, elevated occipital P1 amplitudes were observed for adult vs. child faces in both groups. At longer latency (340–426 ms), a stronger negative deflection to child vs. adult faces, which was source localized in higher visual, parietal and frontal regions, was specifically observed in the PP group. Our study provides evidence for enhanced neural processing of child face stimuli in PP, which might reflect elevated attention capture of face stimuli depicting members from the sexually preferred age group. This study expands our understanding of the neural foundations underlying sexual interest in prepubescent children and provides a promising path for the uncovering of objective biomarkers of sexual responsiveness to childlike body schemes in juveniles.
Exploring the effect of an augmented reality literacy programme for reading and spelling difficulties for children diagnosed with ADHD
Authors: Tosto Crispino , Hasegawa Tomonori , Mangina Eleni , Chifari Antonella , Treacy Rita , Merlo Gianluca , Chiazzese Giuseppe
Published: November 2020

Children diagnosed with attention deficit hyperactivity disorder (ADHD) experience a variety of difficulties related to three primary symptoms: hyperactivity, inattention and impulsivity. The most common type of ADHD has a combination of all three symptom areas. These core symptoms may negatively impact the academic and social performance of children throughout their school life. The AHA (ADHD-Augmented) project focused specifically on the impact of digital technologies’ intervention on literacy skills of children that participated in the pilot study and were diagnosed with ADHD prior to the intervention. Existing research has shown that augmented reality (AR) can improve academic outcomes by stimulating pupils’ attention. AHA project aimed at implementing an evidence-based intervention to improve ADHD children’s reading and spelling abilities through the enhancement of an existing literacy programme with AR functionality. The present paper reports preliminary findings of the pilot study aimed at evaluating the effectiveness of the AHA system in promoting the acquisition of literacy skills in a sample of children diagnosed with ADHD compared to the literacy programme as usual. Background information on the main characteristics and difficulties related to the teaching and learning process associated with children diagnosed with ADHD are first introduced; the design and methodology of the AHA project intervention are also described. The preliminary findings have shown that AHA project succeeded in delivering an AR solution within an existing online literacy programme, which integrates a set of specific technologies and supports interactive educational content, services, assessment, and feedback.
Non-equilibrium approach for binding free energies in cyclodextrins in SAMPL7: force fields and software
Authors: Khalak Yuriy , Tresadern Gary , de Groot Bert L. , Gapsys Vytautas
Published: November 2020

In the current work we report on our participation in the SAMPL7 challenge calculating absolute free energies of the host–guest systems, where 2 guest molecules were probed against 9 hosts-cyclodextrin and its derivatives. Our submission was based on the non-equilibrium free energy calculation protocol utilizing an averaged consensus result from two force fields (GAFF and CGenFF). The submitted prediction achieved accuracy of$${1.38}\,\hbox {kcal}/\hbox {mol}$$1.38kcal/molin terms of the unsigned error averaged over the whole dataset. Subsequently, we further report on the underlying reasons for discrepancies between our calculations and another submission to the SAMPL7 challenge which employed a similar methodology, but disparate ligand and water force fields. As a result we have uncovered a number of issues in the dihedral parameter definition of the GAFF 2 force field. In addition, we identified particular cases in the molecular topologies where different software packages had a different interpretation of the same force field. This latter observation might be of particular relevance for systematic comparisons of molecular simulation software packages. The aforementioned factors have an influence on the final free energy estimates and need to be considered when performing alchemical calculations.
Laparoscopic Heller Myotomy and Dor Fundoplication for the Treatment of Esophageal Achalasia After Sleeve Gastrectomy—a Video Vignette
Authors: Aiolfi Alberto , Foschi Diego , Zappa Marco Antonio , Dell’Era Alessandra , Bareggi Emilia , Rausa Emanuele , Micheletto Giancarlo , Bona Davide
Published: November 2020

Purpose

Esophageal dysmotility and disorders of the lower esophageal sphincter are well documented in morbidly obese patients. Esophageal achalasia has been reported in up to 1% of obese patients but the development of such esophageal motility disorder after laparoscopic sleeve gastrectomy (LSG) is extremely rare. The purpose of this video was to demonstrate the management of a type II esophageal achalasia diagnosed in a 46-year-old female patient 4-year after LSG.

Materials and Methods

An intraoperative video has been anonymized and edited to demonstrate the feasibility of laparoscopic Heller myotomy and anterior Dor fundoplication on the mentioned patient.

Results

The operation started with the section of the perigastric adhesions. Proceeding in a clockwise direction, the esophagogastric junction, the anterior esophageal wall, and the His angle were freed. A residual slightly dilated fundus was found and isolated. After mobilization of the distal esophagus and identification of the anterior vagus nerve, a “hockey stick” myotomy was carried out for 6 cm on the esophagus and for 2 cm on the gastric side. An anterior Dor fundoplication was fashioned using the residual gastric fundus.

Conclusion

Esophageal achalasia in patients that previously underwent LSG is exceptional but should always be suspected in case of pathognomonic symptoms onset. In tertiary referral centers, laparoscopic Heller myotomy and, if technically feasible, an anterior Dor fundoplication seem safe and effective to relieve gastroesophageal outflow obstruction and prevent gastroesophageal reflux.
Trends in HbA1c and other biochemical outcomes of individuals with newly diagnosed type 1 diabetes
Authors: O’Carroll-Lolait A. , Urwin A. , Doughty I. , Schofield J. , Thabit H , Leelarathna L.
Published: November 2020

Background

There is limited data on glycaemic control and cardiovascular risk factor management in newly diagnosed individuals with type 1 diabetes in the first 2 years.

Methods

Retrospective, single centre study from the North West of England, newly diagnosed with type 1 diabetes between 2014 and 2018 (n= 58). HbA1c, blood pressure, lipids and body mass index (BMI) data were collected from electronic patient records from the time of diagnosis until the end of 2 years, stratified by age 16–24 years or ≥ 25 years at presentation.

Results

For those aged 16–24 years (n= 31), median (IQR), HbA1c improved at 6 months from 83 (63–93) to 51.5 (46–75) mmol/mol (p= 0.001) and remained stable 6–24 months. For those ≥ 25 years (n= 27), HbA1c declined from 91 (70–107) to 65 (50–89) mmol/mol, (p< 0.01) at 6 months and declined further to 52 mmol/mol (44–70) at 24 months. At 24 months, 27.8% of all individuals had an HbA1c ≥ 69 mmol/mol. Approximately, a third met LDL (< 2 mmol/L) and total cholesterol (< 4 mmol/L) targets. A total of 58.6% of individuals were overweight/obese (BMI > 25 kg/m2) at 24 months compared to 45.8% at baseline. There were no significant blood pressure changes during the follow-up.

Conclusions

In both age groups, significant improvement of HbA1c occurred within the first 6 months of diagnosis with no statistical difference between the two groups at any of the time points up to 24 months. Despite significant improvements in HbA1c, majority had levels > 53 mmol/mol at 24 months. Alongside the high incidence of obesity and dyslipidaemia, our data support the need for further intensification of therapy from diagnosis of type 1 diabetes.
Words of encouragement: how praise delivered by a social robot changes children’s mindset for learning
Authors: Davison Daniel P. , Wijnen Frances M. , Charisi Vicky , van der Meij Jan , Reidsma Dennis , Evers Vanessa
Published: November 2020

This paper describes a longitudinal study in which children could interact unsupervised and at their own initiative with a fully autonomous computer aided learning (CAL) system situated in their classroom. The focus of this study was to investigate how the mindset of children is affected when delivering effort-related praise through a social robot. We deployed two versions: a CAL system that delivered praise through headphones only, and an otherwise identical CAL system that was extended with a social robot to deliver the praise. A total of 44 children interacted repeatedly with the CAL system in two consecutive learning tasks over the course of approximately four months. Overall, the results show that the participating children experienced a significant change in mindset. The effort-related praise that was delivered by a social robot seemed to have had a positive effect on children’s mindset, compared to the regular CAL system where we did not see a significant effect.
Highly Accurate, But Still Discriminatory
Authors: Köchling Alina , Riazy Shirin , Wehner Marius Claus , Simbeck Katharina
Published: November 2020

The study aims to identify whether algorithmic decision making leads to unfair (i.e., unequal) treatment of certain protected groups in the recruitment context. Firms increasingly implement algorithmic decision making to save costs and increase efficiency. Moreover, algorithmic decision making is considered to be fairer than human decisions due to social prejudices. Recent publications, however, imply that the fairness of algorithmic decision making is not necessarily given. Therefore, to investigate this further, highly accurate algorithms were used to analyze a pre-existing data set of 10,000 video clips of individuals in self-presentation settings. The analysis shows that the under-representation concerning gender and ethnicity in the training data set leads to an unpredictable overestimation and/or underestimation of the likelihood of inviting representatives of these groups to a job interview. Furthermore, algorithms replicate the existing inequalities in the data set. Firms have to be careful when implementing algorithmic video analysis during recruitment as biases occur if the underlying training data set is unbalanced.
Predicting the relationships between gut microbiota and mental disorders with knowledge graphs
Authors: Liu Ting , Pan Xueli , Wang Xu , Feenstra K. Anton , Heringa Jaap , Huang Zhisheng
Published: November 2020

Gut microbiota produce and modulate the production of neurotransmitters which have been implicated in mental disorders. Neurotransmitters may act as ‘matchmaker’ between gut microbiota imbalance and mental disorders. Most of the relevant research effort goes into the relationship between gut microbiota and neurotransmitters and the other between neurotransmitters and mental disorders, while few studies collect and analyze the dispersed research results in systematic ways. We therefore gather the dispersed results that in the existing studies into a structured knowledge base for identifying and predicting the potential relationships between gut microbiota and mental disorders. In this study, we propose to construct a gut microbiota knowledge graph for mental disorder, which named as MiKG4MD. It is extendable by linking to future ontologies by just adding new relationships between existing information and new entities. This extendibility is emphasized for the integration with existing popular ontologies/terminologies, e.g. UMLS, MeSH, and KEGG. We demonstrate the performance of MiKG4MD with three SPARQL query test cases. Results show that the MiKG4MD knowledge graph is an effective method to predict the relationships between gut microbiota and mental disorders.
Delay recovery model for high-speed trains with compressed train dwell time and running time
Authors: Hou Yafei , Wen Chao , Huang Ping , Fu Liping , Jiang Chaozhe
Published: November 2020

Modeling the application of train operation adjustment actions to recover from delays is of great importance to supporting the decision-making of dispatchers. In this study, the effects of two train operation adjustment actions on train delay recovery were explored using train operation records from scheduled and actual train timetables. First, the modeling data were sorted to extract the possible influencing factors under two typical train operation adjustment actions, namely the compression of the train dwell time at stations and the compression of the train running time in sections. Stepwise regression methods were then employed to determine the importance of the influencing factors corresponding to the train delay recovery time, namely the delay time, the scheduled supplement time, the running interval, the occurrence time, and the place where the delay occurred, under the two train operation adjustment actions. Finally, the gradient-boosted regression tree (GBRT) algorithm was applied to construct a delay recovery model to predict the delay recovery effects of the train operation adjustment actions. A comparison of the prediction results of the GBRT model with those of a random forest model confirmed the better performance of the GBRT prediction model.
Characteristics and geological significance of germanium in Taiyuan coal formation of Huainan Coalfield, Anhui, China
Authors: Wu Dun , Zhang Wenyong , Liu Guijian , Zhan Run , Hu Guangqing
Published: November 2020

HN-1# is the first fully working coring well of the Taiyuan Formation (Ty) in the Huinan Coalfield and exploration studies are currently underway on the associated resources of the coal-bearing strata. The HN-1# well is located in the Fufeng thrust nappe structural belt in the south of the Huainan Coalfield. Three coal samples from the Ty were collected from HN-1# and inductively-coupled plasma mass spectrometry and inductively-coupled plasma atomic emission spectrometry were used to determine the Ge content of each sample. Based on proximate and ultimate analyses, microscopy data, and analyses of the ash products, some important findings were made. The Ty coal samples had a relatively high total sulfur (St,d) content (4.24%), thus the coal was considered to be a lower ranked coal (high volatility bituminous coal), which also had a low coal ash composition index (k, 1.87). Collodetrinite was the main submaceral of the Ty coal. Small amounts of pyrite particles were found in the coal seams of the Ty, while the contents of pyrite and algae in the top and bottom sections of the coal seam were relatively high, which meant that the swampy peat conditions which existed during the formation of the coal seams were affected by seawater; also the degree of mineralization of the coal seam was relatively high, which is consistent with reducing conditions in a coastal environment setting. Atomic force microscopy (AFM) experiments showed that the modes of occurrence of Ge in the Ty coal were mainly those for organic-bound and adsorbed Ge species. The organic carbon isotope values for the Ty coal ranged from − 24.1‰ to − 23.8‰, with an average value of − 24.0‰, which is equivalent to the value for terrestrial plants (average value − 24.0‰). The Ge content of the Ty coal was 13.57 mg/kg. The Ge content was negatively correlated with volatile matter and the ash yield.
The development of genome editing tools as powerful techniques with versatile applications in biotechnology and medicine: CRISPR/Cas9, ZnF and TALE nucleases, RNA interference, and Cre/loxP
Authors: Schulze Sabrina , Lammers Michael
Published: November 2020

The huge progress in whole genome sequencing (genomic revolution) methods including next generation sequencing (NGS) techniques allows one to obtain data on genome sequences of all organisms, ranging from bacteria to plants to mammals, within hours to days (era of whole genome/exome sequencing) (Goodwin et al. in Nat Rev Genet 17:333–351, 2016; Levy and Myers in Annu Rev Genomics Hum Genet 17:95–115, 2016; Giani et al. in Comput Struct Biotechnol J 18:9–19, 2020). Today, within the era of functional genomics the highest goal is to transfer this huge amount of sequencing data into information of functional and clinical relevance (genome annotation project). The World Health Organization (WHO) estimates that more than 10,000 diseases in humans are monogenic, i.e., that these diseases are caused by mutations within single genes (Jackson et al. in Essays Biochem 62:643–723, 2018). NGS technologies are continuously improving while our knowledge on genetic mutations driving the development of diseases is also still emerging (Giani et al. in Comput Struct Biotechnol J 18:9–19, 2020). It would be desirable to have tools that allow one to correct these genetic mutations, so-called genome editing tools. Apart from applications in biotechnology, medicine, and agriculture, it is still not concisely understood in basic science how genotype influences phenotype. Firstly, the Cre/loxPsystem and RNA-based technologies for gene knockout or knockdown are explained. Secondly, zinc-finger (ZnF) nucleases and transcription activator-like effector nucleases (TALENs) are discussed as targeted genome editing systems. Thirdly, CRISPR/Cas is presented including outline of the discovery and mechanisms of this adaptive immune system in bacteria and archaea, structure and function of CRISPR/Cas9 and its application as a tool for genomic editing. Current developments and applications of CRISPR/Cas9 are discussed. Moreover, limitations and drawbacks of the CRISPR/Cas system are presented and questions on ethical concerns connected to application of genome editing tools are discussed.
The Anti-enlightenment Tradition as a Source of Cynicism in the European Union
Authors: Ziegler Tamas Dezso
Published: November 2020

This article analyses the effect of the anti-Enlightenment tradition on the functioning of the European Union. This tradition covers a lack of belief in liberal values, human rights, egalitarianism, the rule of law, individualism, tolerance, and the respectful cooperation among people. Its ideological background is not new: its existence is also the reason why scholars started to talk about post-fascism in the twenty-first century. In a number of European Union member states, where autocratic tendencies have recently been witnessed (like in Hungary or Poland), it started to dominate decision-making, while its presence is also visible elsewhere, like in the UK, Germany, and Italy. This article selects four prime examples (the rule of law backlash, refugee law, Brexit, and changes to the single market) to show how arguments containing elements of the anti-Enlightenment tradition are used in a cynical way to support partisan and oppressive politics while maintaining a seemingly inclusive façade of democratic decision-making. In the European Union, this can result in dubious, un-explained measures and great policy changes both at EU and member state level.
On the locality of the natural gradient for learning in deep Bayesian networks
Authors: Ay Nihat
Published: November 2020

We study the natural gradient method for learning in deep Bayesian networks, including neural networks. There are two natural geometries associated with such learning systems consisting of visible and hidden units. One geometry is related to the full system, the other one to the visible sub-system. These two geometries imply different natural gradients. In a first step, we demonstrate a great simplification of the natural gradient with respect to the first geometry, due to locality properties of the Fisher information matrix. This simplification does not directly translate to a corresponding simplification with respect to the second geometry. We develop the theory for studying the relation between the two versions of the natural gradient and outline a method for the simplification of the natural gradient with respect to the second geometry based on the first one. This method suggests to incorporate a recognition model as an auxiliary model for the efficient application of the natural gradient method in deep networks.
Antimicrobial activities of herbal plants from Uzbekistan against human pathogenic microbes
Authors: Egamberdieva Dilfuza , Jabborova Dilfuza , Babich Svetlana , Xalmirzaeva Sokhiba , Salakhiddinov Kamaliddin , Madazimov Madamin
Published: November 2020

In traditional medicine of Uzbekistan, around 20% of herbal plants are used to treat various ailments, including diseases caused by pathogenic bacteria and fungi. Though conventional medicinal plants are common in Uzbekistan, many plant species potentially useful for new pharmaceuticals are less studied. They contain various biological compounds with antibacterial and antifungal activities, that could be developed into drugs. The search for novel antimicrobial compounds, especially against multidrug-resistant pathogens from aromatic and herbal plants is an essential scientific research line. However, the antimicrobial properties of several medicinally important plants from various countries are still unknown. This review aims to provide an up-to-date report on the antimicrobial activity of medicinal plants endemic to Uzbekistan widely used in traditional medicine.
Utility of Kinetic and Kinematic Jumping and Landing Variables as Predictors of Injury Risk: A Systematic Review
Authors: Pedley Jason S. , Lloyd Rhodri S. , Read Paul J. , Moore Isabel S. , De Ste Croix Mark , Myer Gregory D. , Oliver Jon L.
Published: November 2020

Purpose

Jump-landing assessments provide a means to quantify an individual’s ability to attenuate ground reaction forces, generate lower limb explosive power and maintain joint alignment. In order to identify risk factors that can be targeted through appropriate training interventions, it is necessary to establish which (scalar) objective kinetic, kinematic, and performance measures are most associated with lower-extremity injury.

Methods

Online searches of MEDLINE, SCOPUS, EBSCOHost, SPORTDiscus and PubMed databases were completed for all articles published before March 2020 in accordance with PRISMA guidelines.

Results

40 articles investigating nine jump-landing assessments were included in this review. The 79% of studies using drop jump (n = 14) observed an association with future injury, while only 8% of countermovement jump studies (n = 13) observed an association with injury risk. The 57% of studies using unilateral assessments found associations with risk of injury (n = 14). Studies using performance measures (jump height/distance) as outcome measure were only associated with injury risk in 30% of cases. However, those using kinetic and/or kinematic analyses (knee abduction moment, knee valgus angle, knee separation distance, peak ground reaction force) found associations with injury in 89% of studies.

Conclusion

The landing element of jump-landing assessments appears to be superior for identifying individuals at greater risk of injury; likely due to a closer representation of the injury mechanism. Consequently, jump-landing assessments that involve attenuation of impact forces such as the drop jump appear most suited for this purpose but should involve assessment of frontal plane knee motion and ground reaction forces.
Runge–Kutta approximation for $$C_0$$-semigroups in the graph norm with applications to time domain boundary integral equations
Authors: Rieder Alexander , Sayas Francisco-Javier , Melenk Jens Markus
Published: November 2020

We consider the approximation of an abstract evolution problem with inhomogeneous side constraint using A-stable Runge–Kutta methods. We derive a priori estimates in norms other than the underlying Banach space. Most notably, we derive estimates in the graph norm of the generator. These results are used to study convolution quadrature based discretizations of a wave scattering and a heat conduction problem.
African American Language
Authors: Kohn Mary , Wolfram Walt , Farrington Charlie , Renn Jennifer , Van Hofwegen Janneke
Published: November 2020

From birth to early adulthood, all aspects of a child's life undergo enormous development and change, and language is no exception. This book documents the results of a pioneering longitudinal linguistic survey, which followed a cohort of sixty-seven African American children over the first twenty years of life, to examine language development through childhood. It offers the first opportunity to hear what it sounds like to grow up linguistically for a cohort of African American speakers, and provides fascinating insights into key linguistics issues, such as how physical growth influences pronunciation, how social factors influence language change, and the extent to which individuals modify their language use over time. By providing a lens into some of the most foundational questions about coming of age in African American Language, this study has implications for a wide range of disciplines, from speech pathology and education, to research on language acquisition and sociolinguistics.
Paul Bowles
Authors: Tharaud Barry Charles
Published: November 2020

Shows that the writings of Paul Bowles, who is often seen as a literary renegade, owe much to the antinomian American tradition of Emerson and his literary descendants.
At War with The Red Badge of Courage
Authors: Hayes Kevin J.
Published: November 2020

The story of the critical reception of Crane's great Civil War novel from its publication to the present, with particular attention to the effects of later wars on that reception.
Life and Work of Rosalba Carriera (1673–1757)
Authors: Oberer Angela
Published: November 2020

The Life and Work of Rosalba Carriera (1673–1757): The Queen of Pastel is the first extensive biographical narrative in English of Rosalba Carriera. It is also the first scholarly investigation of the external and internal factors that helped to create this female painter's unique career in eighteenth-century Europe. It documents the difficulties, complications, and consequences that arose then -- and can also arise today -- when a woman decides to become an independent artist. This book contributes a new, in-depth analysis of the interplay between society's expectations, generally accepted codices for gendered behaviour, and one single female painter's astute strategies for achieving success, as well as autonomy in her professional life as a famed artist. Some of the questions that the author raises are: How did Carriera manage to build up her career? How did she run her business and organize her own workshop? What kind of artist was Carriera? Finally, what do her self-portraits reveal in terms of self-enactment and possibly autobiographical turning points?
Sacred Sisters
Authors: Callan Maeve
Published: November 2020

Sacred Sisters focuses on five saints: the four female Irish saints who have extant medieval biographies (Darerca, Brigid, Íte, and Samthann), and Patrick, whose writings - fifth-century Ireland’s sole surviving texts - attest to the centrality of women in Irish Christianity’s development. Women served as leaders and teachers, perhaps even as bishops and priests, and men and women worked together in a variety of arrangements as well as independently. Previous studies of gender in medieval Ireland have emphasized sexism and sex-segregated celibacy, dismissing abundant evidence of alternative approaches throughout the sources, including in the Lives of Ireland’s female saints. Sacred Sisters places these generally marginalized texts at its center, exploring their portraits of empowered, authoritative, compassionate women who exemplified an accepting and affirming ethics of gender and sexuality that would be unusual in many mainstream Christian movements in the present day, let alone in the Middle Ages.
Roman Object Revolution
Authors: Pitts Martin
Published: November 2020

Archaeologists working in northwest Europe have long remarked on the sheer quantity and standardisation of objects unearthed from the Roman period, especially compared with earlier eras. What was the historical significance of this boom in standardised objects? With a wide and ever-changing spectrum of innovative objects and styles to choose from, to what extent did the choices made by people in the past really matter? To answer these questions, this book sheds new light on the make-up of late Iron Age and early Roman ‘objectscapes’, through an examination of the circulation and selections of thousands of standardised pots, brooches, and other objects, with emphasis on funerary repertoires, c. 100 bc–ad 100. Breaking with the national frameworks that inform artefact research in much ‘provincial’ Roman archaeology, the book tests the idea that marked increases in the movement of people and objects fostered pan-regional culture(s) and transformed societies. Using a rich database of cemeteries and settlements spanning a swathe of northwest Europe, including southern Britannia, Gallia Belgica, and Germania Inferior, the study extensively applies multivariate statistics (such as Correspondence Analysis) to examine the roles of objects in an ever-changing and richly complex cultural milieu.
UNIVERSALLY MARKETABLE INSURANCE UNDER MULTIVARIATE MIXTURES
Authors: Lo Ambrose , Tang Qihe , Tang Zhaofeng
Published: November 2020

The study of desirable structural properties that define a marketable insurance contract has been a recurring theme in insurance economic theory and practice. In this article, we develop probabilistic and structural characterizations for insurance indemnities that are universally marketable in the sense that they appeal to all policyholders whose risk preferences respect the convex order. We begin with the univariate case where a given policyholder faces a single risk, then extend our results to the case where multiple risks possessing a certain dependence structure coexist. The non-decreasing and 1-Lipschitz condition, in various forms, is shown to be intimately related to the notion of universal marketability. As the highlight of this article, we propose a multivariate mixture model which not only accommodates a host of dependence structures commonly encountered in practice but is also flexible enough to house a rich class of marketable indemnity schedules.
Entamoeba histolytica protein CaBP3 uses a calcium dependent nuclear localisation pathway in mammalian cells
Authors: Wei Kejun , Ghildyal Reena
Published: November 2020

Entamoeba histolytica is a major cause of dysentery that leads to a high level of morbidity and mortality, especially in developing countries. Calmodulin-like calcium binding protein EhCaBP3 of E. histolytica is directly involved in disease mechanisms with roles in cytoskeleton dynamics and scission during erythrophagocytosis in a calcium dependent fashion. Interestingly, EhCaBP3 is also present in the nucleus of E. histolytica. We have used a transfected cell system to show that EhCaBP3 is capable of calcium dependent nucleocytoplasmic trafficking. Our data confirms and extends recent findings suggesting presence of a calcium dependent nuclear transport pathway in E. histolytica.
Psychiatric and psychosocial morbidity 1 year after epilepsy surgery
Authors: Patel S. , Clancy M. , Barry H. , Quigley N. , Clarke M. , Cannon M. , Delanty N. , Murphy K. C. , Cotter D.
Published: November 2020

Objectives:

There is a high rate of psychiatric comorbidity in patients with epilepsy. However, the impact of surgical treatment of refractory epilepsy on psychopathology remains under investigation. We aimed to examine the impact of epilepsy surgery on psychopathology and quality of life at 1-year post-surgery in a population of patients with epilepsy refractory to medication.

Methods:

This study initially assessed 48 patients with refractory epilepsy using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), the Hospital Anxiety and Depression Scale (HADS) and the Quality of Life in Epilepsy Inventory 89 (QOLIE-89) on admission to an Epilepsy Monitoring Unit (EMU) as part of their pre-surgical assessment. These patients were again assessed using the SCID-I, QOLIE-89 and HADS at 1-year follow-up post-surgery.

Results:

There was a significant reduction in psychopathology, particularly psychosis, following surgery at 1-year follow-up (p < 0.021). There were no new cases of de novo psychosis and surgery was also associated with a significant improvement in the quality of life scores (p < 0.001).

Conclusions:

This study demonstrates the impact of epilepsy surgery on psychopathology and quality of life in a patient population with refractory surgery. The presence of a psychiatric illness should not be a barrier to access surgical treatment.
An fMRI investigation of the relations between Extraversion, internalizing psychopathology, and neural activation following reward receipt in the Human Connectome Project sample
Authors: Hyatt Courtland S. , Hallowell Emily S. , Owens Max M. , Weiss Brandon M. , Sweet Lawrence H. , Miller Joshua D.
Published: November 2020

Quantitative models of psychopathology (i.e., HiTOP) propose that personality and psychopathology are intertwined, such that the various processes that characterize personality traits may be useful in describing and predicting manifestations of psychopathology. In the current study, we used data from the Human Connectome Project (N = 1050) to investigate neural activation following receipt of a reward during an fMRI task as one shared mechanism that may be related to the personality trait Extraversion (specifically its sub-component Agentic Extraversion) and internalizing psychopathology. We also conducted exploratory analyses on the links between neural activation following reward receipt and the other Five-Factor Model personality traits, as well as separate analyses by gender. No significant relations (p < .005) were observed between any personality trait or index of psychopathology and neural activation following reward receipt, and most effect sizes were null to very small in nature (i.e., r < |.05|). We conclude by discussing the appropriate interpretation of these null findings, and provide suggestions for future research that spans psychological and neurobiological levels of analysis.
The Extraordinary Relationship between Peacekeeping and Peace
Authors: Walter Barbara F. , Howard Lise Morje , Fortna V. Page
Published: November 2020

Numerous empirical studies have examined the role of third-party peacekeeping in reducing violence around the world. Their results reveal an extraordinary relationship between peacekeepers and peace, notwithstanding a number of well-known problems. This review article has three goals. The first is to summarize the results of past empirical research to move the debate beyond the question ofwhetherpeacekeeping works to the more pressing questions of how, when and why it works. The second is to reveal the limitations of the current quantitative research in order to identify areas in which scholars can make big, new contributions to the field. The final goal is to propose a new research agenda that is heavily evaluative – one that informs policy makers about the specific practices, mission compositions, and mandates that work, and identifies the local, regional, and international conditions that amplify or diminish peacekeeping's effectiveness. This type of research could help reduce the costs of peacekeeping operations, eliminate some of the negative consequences of interventions and save even more lives.
Context, Intersubjectivism, and Value: Humean Constructivism Revisited
Authors: Maclure Jocelyn
Published: November 2020

I defend a version of what Sharon Street called “Humean constructivism.” I'll first sketch out why I think that contextual constructivism provides us with a more plausible understanding of the ontological status of values than both Kantian constructivism and moral realism. In addition to its recognition of the role of evolutionary pressures in the emergence of human morality, contextual constructivism must now clarify the role of historical intersubjectivity in the subsequent development of morality. I will then claim that adding a coherentist module to Humean constructivism provides a satisfactory answer to those who fear that contextual metaethical theories can only be non-cognitivist. Finally, I will sketch out why I think that the notion of a mind-independent “space of moral reasons” is largely compatible with Humean constructivism.
Pragmatic inferences are QUD-sensitive: an experimental study
Authors: RONAI ESZTER , XIANG MING
Published: November 2020

Implicatures serve as an important testing ground for examining the process of integrating semantic and pragmatic information. Starting with Bott & Noveck (2004), several studies have found that implicature computation is costly. More recently, attention has shifted toward identifying contextual cues that modulate this processing cost. Specifically, it has been hypothesized that calculation rate and processing cost are a function of whether the Question Under Discussion (QUD) supports generating the implicature (Degen 2013; Degen & Tanenhaus 2015). In this paper, we present a novel elicitation task establishing what the relevant QUDs are for a given context (Experiment 1). In Experiment 2, a sentence-picture verification study, we extend earlier findings about the effect of QUDs on scalar inference to a different kind of pragmatic inference:it-cleft exhaustivity. For both inferences, we find that under QUDs that bias toward calculation, there is no increase in reaction times, but under QUDs that bias against calculating the inference we observe longer reaction times. These results are most compatible with a constraint-based account of implicature, where QUD is one of many cues. Additionally, we explore whether our findings can be informative in narrowing down precisely what aspect of the inferential process incurs a cost.
Rocky shores as tractable test systems for experimental ecology
Authors: Hawkins Stephen J. , Pack Kathryn E. , Hyder Kieran , Benedetti-Cecchi Lisandro , Jenkins Stuart R.
Published: November 2020

Rocky shore ecology has been studied for a long time, starting with qualitative descriptions and becoming more quantitative and experimental over time. Some of the earliest manipulative experimental ecological studies were undertaken on rocky shores. Many, over time, have made considerable contributions to ecological theory, especially highlighting the importance of biological interactions at the community level. The suitability of rocky shores as convenient test systems for ecological experimentation is outlined. Here we consider contributions from rocky shores to the emerging concepts of supply-side ecology, the roles of competition, predation and grazing, disturbance and succession and positive interactions in structuring communities along environmental gradients. We then address alternative stable states, relationships between biodiversity and ecosystem functioning, and bottom-up and top-down control of ecosystems. We briefly consider the feedback and synergies between ecological concepts and experimental work on rocky shores, whilst still emphasizing the traditional values of marine natural history upheld in JMBA since its first publication. The importance of rigorous experimental designs championed by Underwood and co-workers is emphasized. Recent progress taking advantage of new technologies and emerging approaches is considered. We illustrate how experimental studies have shown the importance of biological interactions in modulating species and assemblage-level responses to climate change and informed conservation and management of coastal ecosystems.