bluuebunny/crossref_metadata_2025 huggingface dataset:
Dukungan Petugas Terhadap Perilaku Konseling Dan Tes HIV (Human Immunodeficiency Virus) Ibu Hamil Di Kelurahan Kepanjenlor Kecamatan Kepanjenkidul Kota Blitar
Authors: Dwi Ertiana
Published: October 2020

regnant women who received HIV Counseling and Testing (KTHIV) services in the work area of ​​UPTD Puskesmas Kepanjenkidul District in Blitar City in 2018 amounted to 65.12% and the least achievement was Kepanjenlor sub-district which was 37.23%. This study aims to determine the relationship of officer support for HIV pregnant women counseling and testing behavior in Kepanjenlor Village, Kepanjenkidul District, Blitar City. This is a correlation study with a case control survey, using a retrospective approach. The population of pregnant women is 75 with 43 samples taken using simple random sampling technique. Research dated June 17-29, 2019, instruments used questionnaires and medical records, using the Spearman rank statistical test. The results of the study obtained officers support for HIV counseling and testing of pregnant women as many as 31 respondents (72.1%) in the good category, counseling behavior and 29 pregnant women HIV tests (67.4%) were in the good category, and based on statistical tests it was found that p value = 0.002 α <0, 05 and coefficient correlation 0.453 showed there was a relationship between the officers' support for counseling behavior and HIV testing of pregnant women in the Kelurahan Kepanjenlor Kepanjenkidul District, Blitar City. Staff support is needed both emotional support, assessment / appreciation support, information support and instrumental support so that pregnant women have the awareness and willingness to do HIV counseling and testing to find out their HIV status.
FAKTOR - FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN DEMAM BERDARAH DENGUE PADA BALITA
Authors: Selni Priska Selni Mayela
Published: October 2020

ABSTRAK

Latar Belakang: Pada tahun 2018 periode Januari sampai dengan Juni yang resikonya tinggi untuk tertular DBD di provinsi Bali merupakan kota Denpasar yaitu kecamatan Denpasar Barat dengan IR = 14,51 per 100.000 Penduduk (dengan total kasus 34 orang). Dugaan penyebaran virus DBD secara cepat dari daerah ke daerah lainya karena berdekatan, sehingga memungkinkan kedekatan daerah dapat mempengaruhi penyebaran kasus DBD.

Tujuan: Untuk mengetahui faktor–faktor yang berhubungan dengan kejadian demam berdarah dengue pada balita di wilayah kerja Puskesmas I Denpasar Barat tahun 2019.

Metodologi: Desain penelitian yang digunakan adalah metode analitik dengan pendekatan Cross Sectional. Jumlah sampel dalam penelitian ini sebanyak 50 responden. Instrument penelitian menggunakan kuesioner. Analisis data yang digunakan adalah analisis univariat dan bivariat dengan uji Chi-Squere.

Hasil Penelitian: Dari 50 responden terdapat riwayat kejadian DBD pada balita 64%, pengetahuan 40%, tindakan PSN 40%, faktor lingkungan 32% di wilayah kerja Puskesmas I Denpasar Barat tahun 2019. Hasil uji chi square terdapat hubungan yang signifikan antara pengetahuan (p value 0,000, OR=11,270), pemberantasan sarang nyamuk (p value 0,000, OR=4,419) dan faktor lingkungan (p value 0,007, OR=3,943).

Simpulan dan Saran: Variabel yang berhubungan dengan kejadian demam berdarah pada balita adalah pengetahuan. Disarankan untuk tenaga kesehatan setempat dapat lebih sering melakukan penyuluhan dengan melibatkan tokoh masyarakat untuk membantu meningkatkan pengetahuan masyarakat tentang DBD.
Hubungan Pengetahuan dengan Tingkat Kecemasan Wanita Premenopause dalam Menghadapi Masa Menopause
Authors: Puspitasari Betristasia
Published: October 2020

Menopause dikenal sebagai waktu penghentian menstruasi secara permanen yang terjadi menyusul hilangnya aktivitas ovarium. Perubahan-perubahan yang terjadi secara fisik, psikis maupun seksual akan menyebabkan wanita yang sedang menghadapi menopause cemas dan khawatir. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan dengan tingkat kecemasan wanita premenopause dalam menghadapi masa menopause. Desain penelitian ini menggunakan desain korelasional dengan pendekatan Croos Sectional. Populasi dalam penelitian ini adalah wanita premenopause, pengambilan sampel menggunakan teknik total sampling didapatkan sampel sebanyak 36 responden. Variabel dalam penelitian ini variable independen adalah Pengetahuan Wanita Premenopause Tentang Menopause dan variabel dependen adalah Tingkat Kecemasan Wanita Premenopause dalam Menghadapi Masa Menopause. Instrument pada penelitian ini berupa kuesioner pengetahuan dan kuesioner skala HARS. Data yang diperoleh diolah dengan editing, coding, scoring, tabulating dan dianalisis menggunakan uji statistik Spermank Rank. Dari hasil uji statistik Spearman Rank didapatkan ρ-value sebesar 0,000 < α (0,05) dan r = 0,553 maka dapat disimpulkan H1 diterima, artinya ada hubungan pengetahuan dengan tingkat kecemasan wanita premenopause dalam menghadapi masa menopause di RT 15-17 Ds. Joho, Kec. Wates, Kab. Kediri. Berdasarkan hasil penelitian, hendaknya informasi tentang menopause lebih ditingkatkan dengan penyuluhan sehingga ibu premenopause dapat menghadapi masa menopause tanpa kecemasan yang berlebih. Pengetahuan yang baik tentang menopause akan menjadi dasar ibu untuk menghadapi masa menopause dengan tenang.
Perbedaan Pengetahuan Ibu Hamil Tentang Kebutuhan Gizi Ibu Hamil Sebelum dan Sesudah Penyuluhan di desa Joho Kecamatan Wates Kabupaten Kediri
Authors: Darmayanti Rofik -
Published: October 2020

ABSTRAC

 

When pregnant mothers should eat foods that contain nutritional value of high quality does not mean expensive food. Nutrition at the time of pregnancy should be increased up to 300 calories per day (Walyani,2015:88). Compared to the mother is not pregnant, the need for the mother will increase protein 68%, folic acid 100%, calcium 50%, and iron 200-300% (Sukarni,2013:115. The purpose of this research is to know the knowledge difference of pregnant women about the nutritional needs of pregnant women before and after the counseling in the village Joho Wates District Kediri Regency. This research uses experimental methods. The population of all expectant mothers in the village of Joho Wates District Kediri 18 people. Sampling techniques use a total sampling. The variables of this research use in this study, free variables are counseling about nutritional needs in pregnant women. In this study, a bound variable is the knowledge of pregnant women about nutritional needs in pregnant women. Therefore, more active health officers are expected to provide counseling. Based on the results of the analysis Ha received which means there is a difference in the knowledge of pregnant women about nutritional needs in pregnant women before and after counseling. The results of the statistical test conducted by SPSS with the formula Wilcoxon Match Pairtest on 18 respondents calculated using the computer showed a Z value of-3,740 with a signification value (σ) of 0.000 (σ ≤ 0.05).
ROLE OF TUMOR MARKERS IN THE DIAGNOSIS OF MALIGNANT PLEURAL EFFUSIONS
Authors: Kandi Subhakar , P Ajay Kumar , Kandi Shravika Reddy
Published: October 2020

As an aid in the differential diagnosis of oxidative pleural effusions tumor markers were investigated. We measured carcinoembrionic antigen (CEA) and a glycoprotein CA 15-3 in the pleural fluid of 33 patients with carcinomatous pleural effusions and of ten patients with tuberculous pleurisy and other causes because we have frequently found those diseases to be associated with exudative pleuritis. CEA and CA 15-3 were significantly higher in carcinomatous pleural fluids than in tuberculous fluids (p value of 0.0287), therefore combined assay of CEA and CA 15-3 may be useful in distinguishing pleural effusions due to malignancies from those of tuberculous origin.
A Gestão Rural e o desafio contemporâneo informacional da Produção Leiteira
Authors: Flamino Leandro Gabriel , Borges Luanderson Centenaro
Published: October 2020

O estudo avalia a gerência rural e o uso de ferramentas administrativas e zootécnicas na produção leiteira. Revela-se a importância de observar a unidade de produção rural leiteira como empresa. O objetivo foi de entender a gestão do empreendimento rural de produção leiteira. Conscientiza-se o uso informacional na gestão rural que é imprescindível para melhoria da saúde gerencial. O método usado foi de revisão bibliográfica. Os resultados apontam que a fusão de conhecimentos da administração rural com os zootécnicos, produzem informações que são elementares para tomada de decisão que é de suma importância para a sustentação da atividade leiteira. Conclui-se que para produzir com eficiência, deve-se conhecer todo o processo produtivo além de controla-lo para poder gerir resultados de produção com qualidade e menos custos.
Estudo Sócio-produtivo e Zootécnico da bovinocultura de corte:Estudo de caso do município de São Vicente de Minas, Brasil
Authors: Barquete Pedro Henrique Andrade , Valentim Jean Kaique , Silva Noronha Cassia Maria
Published: October 2020

A extensão rural busca assessorar o produtor em todos os quesitos da produção, interagindo todos os seus âmbitos, como a nutrição, sanidade, manejo e a sustentabilidade. Frente a isso, o objetivo do presente estudo foi fazer um estudo de caso sobre os produtores de bovinos de corte no município de São Vicente de Minas - MG. Para isso, foi aplicado um questionário abordando características dos produtores e propriedades, manejo, nutrição, sanidade e produtividade do rebanho, além da infraestrutura da propriedade em 20 produtores locais. Observou-se que em São Vicente de Minas, os produtores de carne, se diferenciam da maioria dos pequenos e médios produtores dos Estados de Minas pelo grau de instrução, faixa etária dos produtores e da tradição familiar na atividade.
EPIDEMIOLOGY OF INTRA-ABDOMINAL INFECTIONS IN UKRAINE: RESULTS OF A MULTICENTER STUDY (2014-2015)
Authors: Salmanov Aidyn G. , Kolesnik Anna V. , Andriuschenko Dmytro V.
Published: October 2020

Introduction: Intra-abdominal infections are a common cause of morbidity and mortality worldwide. Early clinical diagnosis and appropriate antimicrobial therapy are the
cornerstones in the management of all infections.
The aim: Aim of our work was to obtain the first national estimates of the current prevalence of intra-abdominal infections and resistance of their causative agents to antibiotics
in Ukrainian hospitals.
Materials and methods: In total of 1986 patients with microbiologically proven IAI were included in the study. The identification and antimicrobial susceptibility to antibiotics
of cultures were determined, using automated microbiology analyzer and Kirby - Bauer antibiotic testing.
Results: Among 1986 patients, 1404 (70.7%) community-acquired and 582 (29.3%) nosocomial infections were observed. Death during hospitalization was reported in 4.1%
community-acquired cases and 7.7% nosocomial cases. The distribution of the microorganisms differed according to the nosocomial or community origin of the infection but
not according to their location. In nosocomial patients were observed with increased proportions of Enterococcus faecalis and Pseudomonas aeruginosa. The carbapenems and
amikacin were the most consistently active against Enterobacteriaceae. Against P. aeruginosa, amikacin, imipenem, ceftazidime and ciprofloxacin were the most active agents
in community-acquired infections, while imipenem, cefepime and amikacin were the most active agents in nosocomial cases.
Conclusions: The significant risk factors defined should be addressed preoperatively to decrease the risk for nosocomial infections. Antibiotics application tactics should be
determined in accordance with the local data of resistance to them in each surgical hospital.
PECULIARITIES OF DIAGNOSTICS OF DEPRESSIONS AND CLINICAL MANIFESTATIONS IN PATIENTS WITH OBESITY AND CONCOMITANT TYPE 2 DIABETES MELLITUS
Authors: Griadil Taras I. , Chopey Ivan V. , Chubirko Ksenia I.
Published: October 2020

Introduction: According to the World Health Organization, depression is a common mental disorder characterized by despair, loss of interest or joy, feelings of guilt and low
self-esteem, sleep disturbance or appetite, lethargy, and poor concentration. There is a series of studies that show the presence of depressive disorders in patients with obesity
concomitant type 2 diabetes mellitus, but in our study, we wanted to demonstrate the degree of severity of these changes.
The aim: Diagnose depression in patients with obesity and concomitant type 2 diabetes mellitus.
Materials and methods: Examine patients with obesity and concomitant type 2 diabetes mellitus and select them for research. For the diagnosis of depression were used:
Patient Health Questionnaire – 2 and 9, Hospital Anxiety and Depression Scale and Hamilton Depression Scale. Along with hypoglycemic therapy, all patients with diagnosed
depression were given individual psychotherapy: cognitive behavioral therapy - 12 sessions per week, interpersonal therapy - 12 sessions per week and bibliotherapy.
Results: Using the questionnaires scales, we found depressive disorders in patients with obesity and concomitant type 2 diabetes mellitus. Along with the diagnosis of depression,
we managed to correct it using individual psychotherapy.
Conclusions: Patients with obesity and concomitant type 2 diabetes mellitus are in a cohort with an increased risk of depression and should be diagnosed early. Given these
patients polypharmacotherapy, treatment for depression should begin with non-drug therapy.
THE ROLE OF ENDOTHELIAL DYSFUNCTION IN THE PROGRESSION MECHANISMS OF NON-ALCOHOLIC STEATOHEPATITIS IN PATIENTS WITH OBESITY AND CHRONIC KIDNEY DISEASE
Authors: Khukhlina Oksana S. , Antoniv Alona A. , Mandryk Olha Ye. , Smandych Vitaliy S. , Matushchak Marta R.
Published: October 2020

Introduction: The study increase in the incidence of non-alcoholic steatohepatitis (NASH) on the background of obesity and chronic kidney disease (CKD) in people of
working age in Ukraine and in the world necessitates the research into mechanisms of mutual burden and the search for new factors in the pathogenesis of this comorbidity
progression .
The aim: To establish the role of endothelial dysfunction in the mechanisms of mutual burden and progression of non-alcoholic steatohepatitis and chronic kidney disease
in patients with obesity.
Materials and methods: 135 patients were examined: of which 52 patients with non-alcoholic steatohepatitis with obesity I degree (1 group), 53 patients with nonalcoholic
steatohepatitis with comorbid obesity of the I degree and chronic kidney disease of the І-ІІ stage (group 2). The control group consisted of 30 practically healthy
persons of the corresponding age and sex. The average age of patients was (45.8 ± 3.81) years.
Results: The results of the study showed that in patients with NASH, a significant increase in the content of NO in the blood was detected in comparison with the index in
PHP (p <0,05) in group 1 - in 2,1 times, in the 2nd group - in 2,6 times (p <0,05). The role of nitrosative stress in the pathogenesis of NASH was proved, the confirmation of
which is the increase in the concentration of nitrosothiols, peroxynitrite and other metabolites NO in the blood. Increased peroxynitrite formation due to the generation of
NO by leukocytes is an important aspect of the damaging effect and inflammation process in NASH. Pathological hyperproduction of NO by endothelial cells and leukocytes
from inflammatory infiltrates in the liver contributes to the development of nitrosative stress in NASH. The established hypernitrate in blood may also be considered
compensatory in response to hyperproduction of ET-1 in all observational groups.
Conclusions: Confirmation of the presence of endothelial dysfunction (ED) in patients with NASH with CKD resulted in a probable growth of the number of desquamated
endothelial cells (DEC) in the 2nd group of patients in 1.9 times (p2 <0.05). Generation by neutrophils during the exacerbation of NASH of a significant number of active
forms of oxygen and nitrogen and hyperproduction of endothelial cells and endometrial lymphocytes with progressive damage to the endothelium (growth of DEC) leads
to significant ED, accompanied by mosaic angiospasm of the arteries due to hyperproduction of ET-1 and parectic vasodilatation of the veins of the portal vein system
because of the hyperproduction of NO.
THE RELATIONSHIP BETWEEN HOMOCYSTEINE LEVEL AND VITAMINS B12, B9 AND B6 STATUS IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors: Shevchuk Sergii V. , Postovitenko Kateryna P. , Iliuk Iryna A. , Bezsmertna Halyna V. , Bezsmertnyi Yurii O. , Kurylenko Iryna V. , Biloshytska Alina V. , Baranova Iryna V.
Published: October 2020

1,,
1
2
ABSTRACT
Introduction: According to present knowledge, hyperhomocysteinemia is one of the risk factors of cardio-vascular pathology. Patients with chronic kidney disease
are known to develop hyperhomocysteinemia more often than those in general population. Іmportant cause of hyperhomocysteinemia is the deficiency of vitamins
В6, В9 and В12 that are involved in homocysteine metabolism. Vitamins deficiency, we believe, can be one of the causes of hyperhomocysteinemia in the patients with
chronic renal failure.
The aim: To analyze the plasma homocysteine level in patients with chronic kidney disease and its assosiation with the levels of vitamins B6, B9, B12 in Ukraine.
Materials and methods: The study involved 148 persons with different stagesis of chronic kidney disease who underwent immunoenzyme determination of total plasma
homocysteine, B9, cobalamin and vitamin В6 status.
Results: It was found that in ukrainian patient population with chronic kidney disease 58.7% of patients have hyperhomocysteinemia. Homocysteine level was shown to increase with the increase of chronic kidney disease stage. Supply of vitamins В6, В9 та В12 in the patients with chronic kidney disease was lower than in apparently healthy persons, but there was significant decrease of folic acid level proportionally to the increase of chronic kidney disease stage. There was close relationship between homocysteine level and folic acid status in the patients with chronic kidney disease, but it appeared to be independent on cobalamin and pyridoxin status.
Conclusions: The obtained data are promising for finding effective means of correction of hyperhomocysteinemia in patients with chronic kidney disease by normalizing the
vitamin status of such patients.
FEATURES OF CLINICAL MANIFESTATIONS, FREE RADICAL, COAGULATION AND AGGREGATION PROPERTIES OF BLOOD IN PATIENTS WITH CRANIOCEREBRAL TRAUMA
Authors: Pinchuk Viktoriia A. , Sylenko Galyna Ya. , Sylenko Yurii I. , Kryvchun Angelina M. , Pilugina Tetiana V.
Published: October 2020

Introduction: In recent years in Ukraine, as in the entire world, there has been an increase in cases of domestic injuries with a raise in the number of patients with craniocerebral trauma and its consequences.
The aim of our research was to study clinical symptoms, the state of free radical oxidation, aggregate and hemocoagulative properties of blood in patients with mild craniocerebral trauma.
Materials and methods: We conducted comprehensive clinical and laboratory examination of 34 patients with mild craniocerebral trauma and 20 apparently healthy patients (the control group). The diagnosis was made under ICD-10. The verification of the diagnosis was based on data from clinical examination, neurological status of neuroimaging (computer tomography and magnetic resonance imaging). The study group included 24 men and 10 women aged from 19 to 40. In addition, 20 apparently healthy individuals of the same age were examined, who comprised the control group (14 men and 6 women). In the blood parameters of all patients, we examined free radical oxidation, hemostasis and aggregation properties of platelets.
Results: The conducted study revealed clinical disturbances, changes in the parameters of free radical lipid oxidation, coagulation and microcirculatory hemostasis. Conclusions:
All patients with mild craniocerebral trauma, develop disturbances in the form of symptoms of microorganic lesion of the central nervous system: convergence weakness in 100% of patients, Mann’s symptom (76.4%), disruption of the function of the cranial nerves (58.8%), signs of pyramidal insufficiency (68.4%), vestibular disorders (94.1%), autonomic vascular dysfunction (100%). Mild craniocerebral trauma is accompanied by the activation of free radical lipid oxidation processes, decreased activity of antioxidant enzymes, hypercoagulation, and increased aggregation properties of platelets.
CORRECTION OF NEUROLOGICAL DEFICIENCY IN PATIENTS WITH ACUTE ISCHEMIC STROKE BY APPLICATION OF DIFFERENT QUALITATIVE COMPOSITION OF INFUSION SOLUTIONS
Authors: Semenenko Andrii I. , Kondratsky Bogdan O. , Hrebtiy Galyna I. , Malyk Svitlana L. , Hinhuliak Mykola G. , Bodnar Roksolana Ya. , Hinhuliak Alexandr M. , Zheliba Lesia M.
Published: October 2020

Introduction: Infusion therapy is an important component in the treatment of patients with acute ischemic stroke (AIS).
The aim: Compare the dynamics of changes neurological deficiency in the application of solutions: 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% in patients with AIS.
Materials and methods: The study included 100 patients with AIS. As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES
130, colloid-hyperosmolar HAES-LX-5%. The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%. The evaluation
of treatment efficacy (magnitude of neurological deficiency) was performed daily for 7 days using the Glasgow Coma Scale (GCS), Full Outline of UnResponsiveness (FOUR) Score, National
Institutes of Health Stroke Scale (NIHSS) and BIS-index.
Results: The conducted research showed that the application of 0.9% NaCl and mannitol did not have a significant effect on the dynamics of neurological deficits according to the GCS, FOUR
and NIHSS scales for 7 days of observation (p>0.05). The use of HES 130 contributed to a statistically significant improvement in the parameters of the GCS (p<0,05), which is confirmed by
significant changes in the BIS-index (p<0,05) during a seven-day infusion therapy. The most significant positive changes were observed in the group with HAES-LX-5%, which was marked
by an improvement in the neurological state during 7 days treatment acoording to the GCS, FOUR and BIS index (p<0.05).
Conclusions: The intergroup analysis of the neurological deficiency confirmed the worst result of treatment in the group with mannitol (p<0,05) and the best result with
HAES-LX-5% (p<0,05).
THEORETICAL SUBSTANTIATION OF THE WAYS OF INCREASING THE EFFICIENCY OF SPECIALIZED MEDICAL AID IN PATIENTS WITH LUNG CANCER
Authors: Ognev Viktor A. , Korop Oleg A. , Zinchuk Andriy M.
Published: October 2020

Introduction: Organizational changes in the context of the transformation of the health system in Ukraine are based on deep and consistent structural and functional
transformations and directed to the providing of specialized care of appropriate quality and efficiency, which are the main target function and a prominent criterion for the
functioning of the national health system.
The aim: Theoretical substantiation of the ways of increasing the efficiency of specialized medical aid in patients with lung cancer.
Materials and methods: Accounting medical records were the main source for the investigation, along with that the results of sociological researches in oncological patients with
lung cancer and the results of expert estimation of the ways of increasing the efficiency of specialized aid for such kind of patients. Some methods were also used, such as system
approach and analysis, sociological method, methods of conceptual modeling and expert values.
Results: An increase of integral efficiency of a specialized medical aid for cancer patients in Ukraine could be reached by expected medical one (introduction of preventive,
diagnostic and therapeutic technologies); social one (healthy way of life; satisfaction by the quality and availability as primary as specialized medical aid) and economic efficiency
(reduction of economic losses because of disability; shortening of inpatient medical aid financing because of less number of patients with neglected stages of the disease). All
of that is grounded on the development and introduction of organizational medical technologies, directed on the early detection of lung cancer and provides justification and
development of an optimized model for the early detection of this disease.
Conclusions: The disadvantages and lack of efficiency of the existing system of specialized cancer care in Ukraine have identified the necessity of a systematic and integrated
solution of the problem of early detection of lung cancer based on the optimization of its model, based on the principles of systemicity and complexity, the use of modern science
and practice achievements in the management and organization of specialized medical care, application between sector interaction and improvement of its information and
communication and organizational-economic components.
CHANGES IN ELECTROMYOGRAPHY TEST RESULTS OF PATIENTS WITH PATHOLOGICAL ABRASION OF TEETH. THE ROLE OF ANTERIOR TEETH IN THE PROCESS OF REHABILITATION
Authors: Tkachenko Iryna M. , Vodoriz Yaroslav Y. , Marchenko Iryna Y. , Shundryk Maryna A. , Korol Dmytro M. , Gurzhiy Olena V.
Published: October 2020

Introduction: Abrasion of teeth significantly affects electromyography results. Analyzing electromyograms of patients who needs complex rehabilitation, it is necessary to
note absence of dissociation of the structure, appearance of spontaneous activity in one of the muscles, presence of the prevailing chewing side, appearance of low-amplitude
oscillations in biocurrents.
The aim: The purpose of this study was to determine the role of anterior teeth in the rehabilitation of patients with increased abrasion.
Material and methods: The experimental group involved patients (men and women) aged 20 to 59 years with increased abrasion of teeth I-III degrees. Patients were
provided with all the necessary complexes of rehabilitation measures: direct restorations with composite materials using the adhesive system of the Vth generation (in case of
light abrasion), indirect ceramic restorations (severe abrasion). All work was conducted in accordance with the Declaration of Helsinki (1964) and was approved by the Ethical
Committee of the academy.
Results: Activity of the right masseter muscle was slightly higher than that of the left one (313.42 ± 97.96 ms. against 226.69 ± 35.39 ms. respectively). At the same time the
resting time of the left and right masseter muscles slightly differs (300.57 ± 30.93 ms. and 307.96 ± 49.47 ms. respectively).
Conclusions: Rehabilitation of patients with increased abrasion using combined methods (direct composite restorations with the adhesive system of Vth generation and indirect
ceramic restorations), give the possibility to restore the masticatory function (evidenced by an increase in the activity of right and leftmasseter muscle on 2%, a decrease in the
rest phase on 20% almost and an increase in amplitude on 2.9%).
THE ASSOCIATION OF LYS198ASN -POLYMORPHISM OF ENDOTHELIN-1 GENE (EDN1) WITH DEVELOPMENT OF ARTERIAL HYPERTENSION IN UKRAINIAN POPULATION
Authors: Smiianova Ylia O. , Pristupa Ludmyla N. , Harbuzova Viktoriia Yu. , Harbuzova Yelizaveta A.
Published: October 2020

Introduction: Arterial hypertension is a multifactorial disease developing under the influence of environmental factors and is genetically determined. One of the genetic markers that is of primary importance in the disease development is endothelin-1 gene (EDN1). Today the association between the polymorphic variants of this gene, particularly Lys198Asn-polymorphism, and the development of arterial hypertension in different populations of the world has been proved.
The aim: To study the association between the Lys198Asn-polymorphism of the endothelin-1 gene and the development of arterial hypertension in Ukrainian population.
Materials and methods: The genotypes were determined by the polymerase chain reaction method, followed by the analysis of the restriction fragment length (PCR-RFLP) in venous blood of 160 patients with arterial hypertension and 110 people in the control group. The statistical analysis was performed using SPSS-17.0.
Results: As a result of genotyping, it was found that in the group of patients with arterial hypertension the ratio of homozygote of the major allele (Lys/Lys), heterozygote (Lys/Asn) and homozygote of the minor allele (Asn/Asn) was 74 (46.3%), 73 ( 45.6%), 13 (8.1%), while in control - 66 (60.0%), 41 (37.3%), 3 (2.7%) respectively. The distribution of genotypes in the experimental groups was statistically significant (χ2 = 6.66; P = 0.036). By the method of binary logistic regression within the dominant and additive model of inheritance, a reliableassociation between the genotype of the Lys198Asn-polymorphism of the ET-1 gene and the development of arterial hypertension was established.
It was shown that carriers of minor allele (Lys/Asn+Asn/Asn) have a risk of arterial hypertension 1.7 (95 % CI = 1.066 – 2.851), and homozygotes Asn/Asn 3.9 (95 % CI = 1.016 – 9.566)times higher than people with Lys/Lys genotype.
In addition, smoking patients with Lys/Asn and Asn/Asn- genotypes have a risk of arterial hypertension 2.6 (95% of SI = 1.224-5.488), and homozygotes of the minor allele (Asn/Asn) 7.3(95% of SI = 1.295-41.639) times higher than the Lys/Lys homozygotes.
Conclusions: Lys198Asn-polymorphism of the endothelin-1 gene is associated with the development of arterial hypertension in Ukrainian population. Carriers of minor allele (Lys/Asn+Asn/Asn) have a risk of arterial hypertension 1.7, and homozygotes Asn/Asn 3.9 times higher than people with Lys/Lys genotype.
ANALYSIS OF THE PHYSICAL DEVELOPMENT OF YOUTH AND THE STATE OF ITS HEALTH
Authors: Kharchenko Oleksandr V. , Kharchenko Nataliya V. , Shaparenko Inna Y. , Sakharova Lyudmyla M. , Yushchenko Yulia P.
Published: October 2020

Introduction: The sharp deterioration in the physical development of the younger generation is worrying. The morbidity of youth has increased by 29.9% compared with the
last century. More than 33% of boys and girls, among first-year students with chronic diseases.
The aim: Assessing the state of the students’ body by examining the results of a survey among the second- and third-year students of the university using a specially designed
questionnaire.
Materials and methods: The material on the assessment of the state of health and the characteristics of the organism has been processed by studying the results of a survey
of young men and women aged 20-23, obtained on the basis of using the developed questionnaire.
Results: Physical development has been studied in accordance with the state of health of the students, as well as a thorough study of a number of criteria: diseases of the
musculoskeletal system were 37.1%, 49.7% and 43.45 among boys aged 20, 22 and 23 and respectively 33.3 %, 38.6% and 47.7% among girls in their 20s, 22s and 23s. The
morbidity of eye was 18.0%, 3.8% and 9.9% among boys aged 20, 22 and 23 years and 17.7%, 17.1% and 7.7% among girls aged 20, 22 and 23 years.
Conclusions: In the structure of morbidities are diseases of the musculoskeletal system, diseases of the nervous system and the organ of vision. Correlation of the characteristics
of the level of students’ health and their physical development have indicators on the level of educational adaptation and the number of diseases.
SOCIAL- PSYCHOLOGICAL FEATURES OF VALUE ORIENTATIONS OF PATIENTS WITH ALCOHOL DEPENDENCE
Authors: Mykhaylyshyn Ulyana В.
Published: October 2020

Introduction: The article considers social-psychological features of value orientations of patients with alcohol dependence. The state of the problem under consideration in
the psychological literature has been studied.
The analysis of empirical research of value orientations of patients with alcohol dependence has been conducted.
The aim: The aim of the paper is to identify social-psychological features of value orientations of patients with al cohol dependence.
Materials and methods: The research has been conducted at full-time treatment department of Transcarpathian Oblast Narcological Dispensary (Uzhhorod, Ukraine).
The experiment involved 42 respondents (29 men and 13 women) of different age, the department patients, suffering on alcoholism. The techniques have been performed
individually with each patient.
The following methods have been used:
1. Method of «Valuable Orientation» by M. Rokich.
2. Questionnaire on Terminal Values (QTV) by I.G.Senin.
3. Purpose-life orientation test (method of PLO) by D.A. Leontiev.
Results: It has been found out that the group hierarchy of values in cases with chronic alcoholism is characterised by an explicit orientation to specific vital values. There is a
characteristic reverse development of the value sphere of an individual in cases with chronic alcoholism, which is displayed in the formation of orientations on the lower levels
of the value system.
The results of empirical research have shown that among the patients with alcohol dependence the preference is given to terminal values, values – goals.
Conclusions: It has been generalised that value orientations are the component of the structure of an individual, which reflects the life experience gained by an individual in
the individual development, and represents the core of consciousness, taking into account how personality makes decisions on important vital issues.
CHANGES IN THE SECRETARY ABILITY OF MONONUCLEAR CELLS IN PATIENTS WITH ATHEROSCLEROSIS AND ACCOMPANYING PATHOLOGY, DEPENDING ON THE C-PEPTIDE BLOOD PLASMA
Authors: Karlova Olena O. , Kuzminska Olena V. , Baryshnik Alina I.
Published: October 2020

Introduction: Atherosclerosis is a trigger in the development of cardiovascular disease. Complications of atherosclerosis give reason to search for new criteria, diagnostic
concepts, treatment methods and active preventive measures.
The aim of our work is to study of the structural changes in the intima-media complex of the common carotid artery, pro-inflammatory cytokines (TNF-α, IL-6) secreted by
mononuclear cells; the level of the intercellular adhesion molecule (according to sICAM-1), the level of the C-peptide of the blood, as well as the study of the relationship between
these factors affecting the development of atherosclerosis.
Materials and methods: In the group of 110 patients are studied the levels of secretion of TNF-α, IL-6, the soluble intercellular adhesion molecule-1, the level
of blood C-peptide, performed of duplex scanning of the brachiocephalic vessels, studied of biopsy of the skin.
Results and conclusions: In the group of patients with atherosclerosis and the accompanying metabolic syndrome, endothelial activation is noted under the influence of risk
factors (hyperinsulinemia, arterial hypertension, hypercholesterolemia), accompanied with the activation of mononuclear cells (with marked hyperproduction of proinflammatory
cytokines (IL-6) and thickening of the intima-media complex of the common carotid artery with an increase in body weight. Patients with metabolic syndrome develop
microangiopathy (edema of endothelial cells, thickening and reduplication of the basement membranes, focal reaction of the pericytes).
SPECIFIC ASPECTS OF CLINICAL COURSE IN CASE OF COMBINATION OF CHRONIC PANCREATITIS AND CONCOMITANT VIRAL HEPATITIS C
Authors: Babinets Liliya S. , Shaihen Olena R. , Homyn Halyna Ol. , Halabitska Iryna M.
Published: October 2020

Introduction: In this publication we analyzed the specific aspects of clinical course in case of combination of chronic pancreatitis and concomitant viral hepatitis C.
The aim: Discover the clinical course of chronic pancreatitis with concomitant viral hepatitis C .
Materials and methods: 57 patients with chronic pancreatitis and concomitant viral hepatitis c were examined. Diagnosis of chronic pancreatitis and viral hepatitis c was
verified based on disease history, clinical symptoms and the results of clinical-instrumental tests. Clinical and biochemical investigations in people with chronic pancreatitis
were done in exacerbation and unstable remission phases and for people with viral hepatitis C - in stable remission phase.
Results: In patients, who have chronic pancreatitis with concomitant hepatitis C, pain, dyspeptic syndromes and defecation disturbances take the major place in clinical course
of the disease. These symptoms were more severe than in the control group (possible difference in numbers in the group of patents with isolate viral hepatitis C (p<0,05).
Conclusions: According to the studies data-the negative influence of concomitant viral hepatitis C in clinical course of chronic pancreatitis was identified.
CLINICAL AND AUDIOLOGICAL VALUES IN THE EARLY DIAGNOSIS OF HEARING IMPAIRMENTS AND RISK GROUPS AMONG SHIP REPAIR WORKERS
Authors: Kononov Оlexander Ye. , Matiukha Larysa F. , Batsiura Ganna V. , Protsiuk Olha V. , Klymenko Liliana V. , Veselova Tatyana V.
Published: October 2020

Introduction: The hazardous effect of industrial noise exposure on ship repair workers has been highlighted in a number of studies. However, no data are currently available
for studying the effect of noise exposure on the auditory system and general health of ship repair workers.
The aim: The study is focused on the early diagnosis of hearing impairments and identifying risk groups among the workers.
Materials and methods: It was examined two groups of workers of approximately the same age and length of employment. The Group 1 included workers from the Azov
Shiprepair Yard (Mariupol city, Ukraine) who were exposed to workplace noise impact of less than 80 dBA threshold level, the workplace noise level in the Group 2 was
above 80 dBA. Audiometric testing was conducted in a sound-treated room using the MA 31 clinical audiometer (Germany).
Results: Our findings indicate that all the noise-exposed groups of ship repair workers should be conducted audiometric testing. The hearing levels at the audiometric test
frequencies of 4, 6 and 8 kHz, as well as differential thresholds at the audiometric test frequencies of 4 kHz by the Luscher-Zwislocki method should be taken into account. Such
complaints as increased annoyance, sleep disorder, tinnitus aurium, hypertension should be considered as most hazardous.
Conclusions: We recommend that the ship repair workers undergo routine medical check-ups and systematic prophylactic observation. All these preventive measures will
contribute to the early detection of hearing impairments, thereby timely preventing the development and progression of occupational sensorineural hearing loss.
PREVALENCE OF ACIDIC AND NON-ACIDIC REFLUXES IN PATIENTS WITH FUNCTIONAL DYSPEPSIA AND ITS RISK FACTORS INVESTIGATED BY MEANS OF MULTICHANNEL INTRALUMINAL PH-MONITORING
Authors: Melashchenko Sergii , Chernobrovyi Viacheslav , Ksenchyn Oleg
Published: October 2020

Introduction: Previous studies performed by conventional pH-monitors showed that a significant proportion of patients with functional dyspepsia have abnormal acidic gastroesophageal reflux. The investigation, using advantages of multichannel intraluminal pH-monitoring, were not conducted. The aim to reveal the prevalence of all types of refluxes in patients with functional dyspepsia and to estimate risk provoking factors for abnormal reflux. Methods and materials: Patients were divided into 6 groups. The 1st, 2nd and 3rd groups covered 127 adult patients with epigastric pain syndrome, postprandial distress syndrome and mixed variant respectively. The 4th included 69 NERD patients suffered from frequent (more than one episode per week) heartburn. The 5th group also consisted of 22 NERD patients without heartburn or with rare heartburn-regurgitation. The reference group included 30 subjects without dyspeptic complaint and established diagnoses of gastro-esophageal diseases. For all persons the 200-min MII-pH-monitoring was performed with standardized stimulating breakfast (507kcal, 100 mg caffeine, 300ml) recording basal and postprandial phases. Results: It was found that the difference in comparison to the reference group in the number of refluxes is determined by the number of acid refluxes and not by weakly-acidic and weakly-alkaline refluxes. Patients with functional dyspepsia from all subgroups had an excessive amount of acidic refluxes in comparison with the reference group - 3.7±0.7, 4.7±0.8 and 2.8±0.7 vs 1.8±0.3 episodes (p<0.05). Using the previously obtained threshold values for abnormal acidic reflux (> 6 episodes per 200 min.) and total refluxes (>17 episodes per 200 min.) it was revealed that 22.8% patients with FD had abnormal GER. In addition, 16.5% had an isolated excess of non-acidic reflux. All three dyspeptic groups didn’t have a significant difference in the distribution of patients among subtypes of abnormal presence or absence of acidic/non-acidic refluxes. Conclusion: In functional dyspepsia abnormal acidic reflux are common and affect 22.8% of patients. It is independently associated with hiatal hernia (OR=4.17), previously healed a peptic ulcer (OR=3.90), occasional heartburn (OR=1.25), body mass index (OR=1.11), younger age (OR=0.97).
DYNAMICS OF HEART RATE VARIABILITY UNDER THE INFLUENCE OF COURSE YOGA BREATHING EXERCISES ON HEALTHY YOUNG PEOPLE
Authors: Sheiko Nataliia I. , Feketa Volodymyr P.
Published: October 2020

Introduction: Heart rate variability is a highly informative non-invasive method of research not only for the functional state of the cardiovascular system and also for the integrative regulatory activity of the autonomic nervous system. The positive effect of diaphragmatic breathing is positive in the mode of biological feedback using portable devices, but there is little evidence of the use of yoga breathing gymnastics in order to influence the heart rate variability. The aim: To compare the possibilities of using courses of breathing gymnastics of yogis and diaphragmatic breathing sessions in the mode of biological feedback using a portable device. Materials and methods: The study involved 70 practically healthy foreigners, who were divided into 2 groups of 35 people. Participants of the 1st group daily engage in respiratory exercises pranayama for 15 minutes in 1 month. Participants in the 2nd group used the MyCalmBeat portable device. Heart rate variability was registered by using the computer diagnostic complex “CardioLab” (“KhAI-Medika”, Ukraine). Results: In both groups there was similar dynamics of heart rate variability indices, but its severity was different. The common integral effect was a significant growth of heart rate variability both according to statistical and spectral indicators – total power increased, as well as high-frequency component. The power of the very-low frequency waves has probably decreased only in the group with the device. In the percentage structure of the cardiac rhythm spectrum, the specific weight of very-low frequency component and the percentage of high-frequency component increased. Conclusions: Respiratory gymnastics yoga for 15 minutes daily contributes to the growth of heart rate variability through the suppression of the central link (very-low frequency component) of regulation of cardiac rhythm and increased activity of parasympathetic influences (high-frequency component), as well as the redistribution of regulatory activity of the central nervous system between the central and peripheral links of regulation of the cardiac rhythm in favor of the latter.
DYSLIPIDEMIA AS RISK FACTOR OF ATHEROSCLEROSIS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Ternushchak Tetyana M. , Tovt-Korshynska Marianna I.
Published: October 2020

Introduction: Atherosclerosis is one of the most common co-morbidities observed in chronic obstructive pulmonary disease. A better understanding of mechanisms of
atherosclerosis in patients with chronic obstructive pulmonary disease is needed to improve clinical outcomes.
The aim: to evaluate the plasma levels of lipid parameters, atherogenic indices, systemic inflammatory markers and to assess their relationship with the severity of chronic
obstructive pulmonary disease.
Materials and methods: A total of 72 subjects diagnosed with chronic obstructive pulmonary disease and 41 healthy controls, the same gender and age categories, with ≥
10 pack years smoking history, were followed-up of about 5.8 years. Blood tests with determination of lipid profiles, atherogenic indices and systemic inflammatory markers
were conducted in remaining patients who fulfilled inclusion criteria of the study.
Results: Triglyceride, atherogenic index of plasma, cardiogenic risk ratio and atherogenic coefficient values were significantly higher, but high-density lipoprotein cholesterol
– significantly lower in patients with chronic obstructive pulmonary disease than in controls. Lipid profiles were similar in lower-risk (stage A and B) and higher-risk (stage C
and D) patients with chronic obstructive pulmonary disease. The analysis showed that atherogenic indices and serum high sensitive C-reactive protein were inversely correlated
with forced expiratory volume in 1 sec, especially in higher-risk patients with chronic obstructive pulmonary disease (r = - 0.61 p < 0.05; r = - 0.57 p < 0.05; r = - 0.54 p <
0.05 and r = - 0.49 p < 0.05 respectively).
Conclusions: Atherogenic indices and serum high sensitive C-reactive protein can be considered as useful biochemical markers to predict an early stage of atherosclerosis
especially in higher-risk patients with chronic obstructive pulmonary disease.
ALLERGIC RHINITIS AND ASTHMA CO-MORBIDITY
Authors: Sukhan Victoria S.
Published: October 2020

Introduction: The combination of asthma and allergic rhinitis can affect the mutual encumbrance to which other pathogenetic mechanisms join, which worsen the course
of both diseases.
The aim of work is to analyze the features of the genotype and phenotype in patients with a co-morbidity of asthma and allergic rhinitis.
Materials and methods: In order to detect the features of asthma and allergic rhinitis, 115 patients were examined. Patients were divided into two groups: the first included
58 patients with allergic asthma and allergic rhinitis co-morbidity, the second – 57 patients with non-allergic asthma morbidity.
Results: For the group of patients with allergic asthma with concomitant allergic rhinitis, the first manifestation of allergy in childhood is characteristic (allergic rhinitis, hay
fever, atopic dermatitis). For this group of patients characterized by a heavy family allergic history. Symptoms of allergic rhinitis aggravate the course of asthma. Characteristic
correlation of symptoms of allergic rhinitis with distal obstruction and pronounced lability of bronchi. In these patients, the total increase in IgE and blood eosinophilia, in 1,5
times increased blood histamine and the level of exhaled NO2 have been increased. Also, asthma control with concomitant allergic rhinitis was significantly worse than in an
isolated asthma group (p <0.05).
Conclusion: The obtained data allow to distinguishing the phenotype of patients with asthma and allergic rhinitis co-morbidity.