bluuebunny/crossref_metadata_2025 huggingface dataset:
Efektivitas Pembelajaran Pendidikan Agama Islam Dalam Jaringan Masa Pandemi Covid-19 di SMKN 1 Al-Mubarkeya
Authors: Sarah Rahma , Misnawati Misnawati , Mawaddah Sri
Published: July 2023

This study uses a descriptive quantitative approach, with data collection methods using questionnaires and documentation. The selection of samples using the Probability Sampling technique with the simple random sampling method from class X, XI and XII. The research was carried out by distributing questionnaires made with Google Forms and then sharing them online via Whatsap. Data analysis used quantitative descriptive analysis. The results of the student's research stated that online learning was still not effective based on data acquisition from 25 statements given by researchers to 97 respondents. It can be seen from the average results on the indicators of learning effectiveness. First, active learning obtains an average value of 2.62 belonging to the less effective category. Second, various learning methods obtain an average value of 3.09 belonging to the less effective category. Third, learning motivation obtains an average value of 2,826 belonging to the less effective category. Fourth, the democratic atmosphere obtained an average value of 2.6 belonging to the less effective category. Fifth, lessons at school need to be linked to real life, obtaining an average score of 2.94 belonging to the less effective category. Sixth, conducive learning interactions obtain an average value of 2.34 belonging to the ineffective category. And seventh, the diagnosis of learning difficulties obtained an average value of 2,746 belonging to the less effective category. Thus, the total average of all indicators obtained a value of 2.7374 belongs to the less effective category. So that learning Islamic Religious Education online during the Covid-19 pandemic at SMKN 1 Al-Mubarkeya Ingin Jaya Aceh Besar was declared less effective.
Kajian Etimologi dan Terminologi Metodologi Pembelajaran Pendidikan Agama Islam
Authors: Darmiah Darmiah
Published: July 2023

Islamic religious education as a system is an activity that includes objectives, curriculum, teachers, methods, approaches, infrastructure, environment, management and others that are interrelated and form a unified system. The student education methodology must be adapted to the needs and characteristics of students, so that teachers can easily convey it to students, and students can also easily accept and understand lessons from teachers, because teachers can adjust to students' souls. . students with such learning. Methodology comes from the Greek language and consists of two words, namely "Metodos" which means way or way and "Logos" which means science. In short, methodology is the science (discussion) of methods or methods. Although that method itself is the most convenient and fastest way to do things. There are also those who believe that the method is the path taken to achieve a goal. The definition of method in Zakia Drajat's terminology is a systematic way of working to facilitate the implementation of an action to achieve a goal. From Arifin's point of view, the method is the path one takes to achieve a goal. The definition of method in technical language is different. According to Hasan, Langgilang defines the method as a way or path that must be taken to achieve educational goals.
Pembelajaran Pedagogik Spiritual melalui Kearifan Lokal
Authors: Masbur Masbur
Published: July 2023

Learning is a concept of two dimensions of activity, namely learning that needs to be planned and updated, and directed to mastering a number of competences as an image of learning outcomes. This article aims to reveal the influence of local wisdom and spiritual learning. With local wisdom-based education, we can optimize the creation of education that can make sense of Indonesian human life. It means education will then be able to become a spirit that can color Indonesian human dynamics forward. The research method used in this study is the method of content analysis/meta analysis. Content Analysis is a study that combines the results of many original, systematic, planned studies, retrospective observations, with formal statistical analysis. The results of this study found that spiritual learning is one of the factors that influence the behavior of educated participants alongside other factors such as the intellectual, emotional, environmental, cultural and personal abilities of students. Humans have a spirituality to achieve a healthier self-development because we have that potential. This spiritual pedagogic, invites teachers to practice this value in learning activities that are mixed with local awareness of educated participants. Local origins that have spiritual values are explored and practiced in the learning process.
Strategi Peningkatan Profesionalisme Guru dalam Pembelajaran
Authors: Nidawati Nidawati
Published: July 2023

Teacher professional development and development must be in line with similar activities for education staff in general. In the learning process, teachers play a very strategic role within the framework of carrying out their functions and realizing national education goals, where students are future human beings who are expected to be able to master science and technology, be skilled, have national character and character, and become religious people. The role of the teacher can hardly be replaced by another, especially in a multicultural and multidimensional society, where the role of technology to replace teacher tasks is still minimal. Even if sufficient learning technology is available, the real role of the teacher will not be replaced. The history of education in Indonesia has recorded that the teaching profession is a profession whose importance is recognized and its strategic role is recognized for the future development of the nation.
Neurocisticercosis y epilepsia en un hospital universitario de Popayán, Colombia: una serie de casos
Authors: Hurtado Campo Karolina Stefany , Giraldo Jiménez Brenda Yuliana , Galindez Muñoz Mario Ernesto , Daza Pérez Jorge Alfredo , Vásquez-A Luis Reinel
Published: July 2023

INTRODUCCIÓN:
La neurocisticercosis es una infección del sistema nervioso central causada por el estadio larvario del cestodo Taenia solium, y se estima que puede ocasionar hasta 30% de los casos de epilepsia en los países donde esta parasitosis es endémica. El objetivo de este estudio fue determinar la frecuencia de pacientes que presentaron epilepsia como secuela de neurocisticercosis en un hospital universitario en Popayán.

MATERIALES Y MÉTODOS:
Se realizó un estudio retrospectivo con todos los pacientes con diagnóstico de neurocisticercosis que ingresaron al Hospital Universitario San José entre enero 2014 y diciembre 2018 que cumplieron los criterios de inclusión.

RESULTADOS:
Se encontraron 50 pacientes, de estos, 40 (80%) reingresaron, encontrándose que 37 (74%) presentaron epilepsia como secuela. Las edades más afectadas fueron la de 41 a 60 años; 48 (96%) provenían del departamento del Cauca en especial de Mercaderes, y 33 (66%) de área rural. El síndrome convulsivo fue la manifestación clínica de ingreso más frecuente. La TAC fue la técnica de imagen de elección.

CONCLUSIÓN:
El departamento del Cauca se considera como una de las áreas endémicas para neurocisticercosis en Colombia, y la epilepsia secundaria es un secuela común.
Infarto cerebral en mujer joven con la enfermedad por el coronavirus del 2019 y sin factores de riesgo cardiovasculares: reporte de caso
Authors: Rentería-Roa Jairo Andrés , Suarez-Acosta Carolina del Rosario , Peláez-Arroyave Luis Guillermo , Palacio-Sánchez Andrés Felipe
Published: July 2023

INTRODUCCIÓN:
La COVID-19 se acompaña de eventos tromboembólicos venosos y arteriales en pacientes con historia de hipertensión y aterosclerosis. Se reporta el caso de una paciente joven y sin factores de riesgo cardiovascular que adquirió la infección por el SARS-COV2 y luego presentó un accidente cerebrovascular isquémico.

CASO:
Paciente de 44 años hospitalizada por la covid-19 en tratamiento protocolario con anticoagulación, esteroide y oxígeno suplementario. Al día 7 del inicio de los síntomas respiratorios presentó infarto cerebral por trombosis de arteria carótida derecha, arteria cerebral media derecha e izquierda y edema cerebral hemisférico derecho, tras lo cual fue diagnosticada con muerte encefálica. El estudio vascular no documentó una etiología diferente a la covid-19.

DISCUSIÓN:
Se plantea que la infección condiciona un estado inflamatorio sistémico, endotelialitis, ulceración de placas ateroscleróticas preexistentes e hipercoagulabilidad. Lo anterior facilita la aparición de trombosis vascular. Es frecuente encontrar elevación de reactantes de fase aguda y de los productos del metabolismo de la fibrina. El accidente cerebrovascular (ACV) isquémico se ha descrito en el 1 al 5 % de los pacientes con la covid-19. En pacientes con factores de riesgo cardiovascular, durante las primeras 2 semanas desde el inicio de los síntomas respiratorios, el compromiso isquémico suele afectar a múltiples territorios vasculares.

CONCLUSIÓN:
La covid-19 por sí sola es un factor de riesgo para trombosis arterial secundaria a la inflamación sistémica y estados de hipercoagulabilidad, por lo que debe ser tenida en cuenta en el estudio de ACV isquémico en pacientes jóvenes.
Modelo de gestión del residuo de cascarilla mediante cogeneración en pymes arroceras, un estudio de caso
Authors: Nuncira Negrete Carlos A.
Published: July 2023

En Colombia la molienda de arroz se desarrolla en muchos casos sin tener en cuenta consideraciones de sostenibilidad, debido principalmente a la inadecuada gestión de sus residuos lo que genera impactos ambientales negativos que deben ser considerados. El objetivo de este estudio es el diseño de un modelo de gestión sostenible del residuo de la cascarilla en pymes arroceras a través de un estudio de caso. Se propone el aprovechamiento energético mediante cogeneración partiendo de la caracterización del proceso. Se seleccionó la tecnología de generación mediante turbina de vapor con base en criterios técnicos, ambientales y financieros. Una vez se realizó el diseño preliminar, los análisis financieros mostraron que la mejor opción resulta cuando se incorporan los incentivos tributarios estatales. La cogeneración se constituye como una opción válida para el aprovechamiento de los residuos agroindustriales de los molinos arroceros, aun en empresas con pequeña escala ya que suple una necesidad interna energética y de calor, mejora la competitividad y el desempeño ambiental de los molinos arroceros.
Teoría de sistemas: De Ludwig von Bertalanffy a Niklas Luhmann
Authors: Vázquez Pérez Eduardo Daniel
Published: July 2023

En la actualidad, el impacto que ha tenido la teoría de los sistemas -por supuesto, en algunos países del mundo- radica en el hecho de que nos permite comprender el funcionamiento del mundo, desde el sistema más pequeño hasta el más complejo, e incluso de lo complejo sumergido e interactuando en redes de más redes de complejidad, toda vez que el paradigma sistemático indica que todo es mayor a la suma de sus partes, pero este todo dinámico e interconectado comunicacionalmente, debe ser diferenciado del entorno, con el objetivo de identificar las propiedades que lo hacen característico y, a su vez, trasladarlo a cualquier isomorfismo, es decir, a cualquier nivel de realidad en el que vivimos.
Los lazos sociales en la contemporaneidad. Desde el individualismo hacia la ética del cuidado
Authors: Carmona Gallego Diego Ezequiel
Published: July 2023

La contemporaneidad es una época caracterizada por lo que diversos autores han denominado crisis civilizatoria, de paradigma o policrisis. Este artículo busca comprender el mencionado diagnóstico, a partir del análisis de emergentes tales como las formas contemporáneas del individualismo y las nuevas modalidades del lazo social centradas en la búsqueda de comunidad. En primer lugar, se realiza una revisión bibliográfica de contribuciones provenientes de las ciencias sociales, distinguiendo entre un individualismo relacionado con la singularidad, y un individualismo que aspira a la autosuficiencia. En segundo lugar, se desarrolla un análisis de la metamorfosis de los lazos sociales. En tercera instancia, se presenta la propuesta de una ética - política del cuidado que permita repensar los lazos sociales y horadar el individualismo autosuficiente, a partir del reconocimiento de la vulnerabilidad y la interdependencia como marcas de la condición humana. Se concluye que los modos de relación basados en el cuidado, y la posibilidad de construir comunidades a partir de prácticas de cuidado de sí, de los otros y de los ecosistemas, constituyen tal vez la más importante clave para el abordaje del individualismo narcisista.
Análisis del discurso multimodal de la representación del género femenino en los spots publicitarios emitidos por el Canal Caracol
Authors: Gómez Serna Yurian Lisbeth , Tous Polo Daniela , Valoyes Villa Sandra Patricia , Cano Ramírez Carlos Mario
Published: July 2023

Las representaciones que se hacen del género femenino en la publicidad son manifestaciones de las creaciones de la cultura, donde el lenguaje evidencia los conceptos existentes en una sociedad alrededor de la mujer. Este estudio se propuso indagar acerca de la configuración de la representación del género femenino en spots emitidos en el canal Caracol alrededor del Día Internacional de la Eliminación de la Violencia hacia las Mujeres, del 21 al 28 de noviembre del 2022 Para abordar este fenómeno se tuvo en cuenta el estereotipo como una idea simplificada de un determinado grupo social; el prototipo, como un molde de referencia biológica al género; y el rol, entendido como las acciones que desempeña una persona en los que se le encasilla y tiene implicaciones desde la construcción social del género. La metodología del análisis del discurso se abordó a partir del discurso multimodal, para abarcar el fenómeno desde los aspectos discursivos de lo visual, lo auditivo y lo verbal. Los planteamientos teóricos de los Estudios Culturales y Stuart Hall (2013) fueron la base para analizar los datos obtenidos. Del estudio resultaron cinco estereotipos emergentes, entre los que se destacó el estereotipo de mujer clásico-moderna, y dos cualidades recurrentes en las mujeres de los comerciales: protección y cuidado hacia el otro.
Pseudo-Measurement based State Estimation for Railway Power Supply Systems with Renewable Energy Resources
Authors: Pan Zheng , Che Liang , Tu Chunming
Published: July 2023

State estimation is critical for railway power supply systems (RPSSs).
Pseudo-measurement is commonly used in state estimation. However, the
fluctuations of renewable generations and railway traction loads in RPSS
may introduce data noise, which will jeopardize the accuracy of the
generated pseudo-measurements and thus impact the state estimation.
Additionally, when learning the historical measurement data sequences,
the traditional pseudo-measurement model is likely to have overfitting,
which will further impact the accuracy of pseudo-measurements, thereby
affecting the accuracy of state estimation. To address these issues,
this paper proposes a high-accuracy pseudo-measurement-based state
estimation approach for RPSSs. Firstly, a denoising autoencoder
(DAE)-based method is used to mitigate the impact of data noise on the
accuracy of pseudo measurements, and a gated recurrent unit (GRU)-based
method is used to adaptively learn the historical measurement data
sequence, thereby improving the accuracy of pseudo measurements. Next,
the pseudo-measurement weights are obtained by generating
pseudo-measurement variances using the Gaussian mixture model. Finally,
the pseudo measurements and real-time measurements are integrated by
weighted least squares to realize the state estimation of RPSS. The
effectiveness and accuracy of the proposed method are verified by
simulation on a modified IEEE 33-node system which includes a railway
traction substation and renewable generations.
GENETIC COMPONENT OF RETINOBLASTOMA IN BUKAVU, DEMOCRATIC REPUBLIC OF CONGO
Authors: Budwaga Manwa Baudouin , Kabesha Dany Biraheka , Bisimwa Patrick N. , Baenyi Patrick , Nabuloho Eric Heri , Balezi Jean de Dieu Murhula , K.Tsongo Zacharie , Wembonyama Pr Stanis O. , Chirimwami Raphaël Bulakali
Published: July 2023

Retinoblastoma (RB) is a genetically predetermined intraocular malignant
tumor, common in childhood, initiated by a mutation in the retnoblastoma
gene (RB1), located on the long arm of chromosome13 (13q14). The lack of
information on the genetics of RB in Bukavu motivated this study, with
the aim of presenting the spectrum of mutations. Materials and methods
This is an analytical cross-sectional study of 10 individuals, including
5 RB carrier children and 5 parents. Their deoxyrubonucleic acid (DNA)
was extracted and 11 exons within the RB1 gene were amplified by
Polymerase chain reaction, sequenced and analyzed by various
bioinformatics tools. Result All the children had unilateral RB,
diagnosed mostly at an age ≥2 years, male gender predominated, history
of RB was absent in all subjects. A total of 11 of the 27 most
frequently mutated exons that make up RB1 had been analyzed. The types
of deleterious mutations found in exons 8 and 20 alone, in the 5
children and one parent, were of the following types: missense (26.6%
vs. 16.7%), deletion (11.1% vs. 50%) and insertion (66.7% vs.
33.3%), generally associated with a frameshift and a splice site
change. Disruption of protein synthesis was observed in all the children
and in only one parent. Conclusion The deleterious genetic
mutations identified by the study were known. The study suggested
additional studies, integrating environmental factors that are currently
believed to be involved in the occurrence of RB.
Super-scavengers: Vertebrates outperform invertebrates and microbes at removing carrion from a tropical forest
Authors: Iyer Bhavya , Dutta Sutirtha , Qureshi Qamar , Jhala Yadvendradev
Published: July 2023

Scavenging by vertebrates is an important ecosystem service as they are
known to remove carrion more efficiently than other taxa. How long would
carrion persist bereft of vertebrate scavengers? Our study addresses
this question in a forested landscape, by comparing carrion utilization
by vertebrate scavengers, invertebrates, and microbes (decomposers). To
understand carrion removal, we used experimental placement of chicken
carcasses in a dry deciduous forest near Panna Tiger Reserve, Madhya
Pradesh, India. Carcasses were placed under different treatment
conditions (vertebrate scavenging, invertebrate scavenging, microbial
decomposition and control to account for moisture loss), by
experimentally excluding other scavengers. The daily rate of carcass
utilization and proportion of carrion biomass remaining differed between
treatments. Vertebrates consumed carcasses at the highest rates,
removing 83% of carcass biomass in one day (CI 95%), followed by
invertebrates (7.3%) and microbes (3.9%). Additionally, desiccation
accounted for another 3.6% weight loss per day. The study showed
drastic differences in carrion removal rates between taxa, indicating
the irreplaceable role of vertebrates in the scavenging community of
tropical forests, without whom carcasses would persist over prolonged
periods. Our results support earlier studies that found overwhelming
influence of vertebrate scavengers on carrion removal compared to other
scavenging guilds.
High resolution gamma-ray spectrometry logging applied in the interpretation of sedimentary processes and environments of the Itararé Group (Permo-Carboniferous), Paraná Basin, Santa Catarina state
Authors: Miranda André Dorival , Nascimento Marivaldo dos Santos , Castro Neivaldo Araújo de , Baesso João Pedro , Balistieri Patrícia da Rocha M. N.
Published: July 2023

Outcrop gamma-ray spectrometric logging in the upper strata of the Campo Mourão Formation and lower strata of the Taciba Formation were used to investigate: (i) the influence of lithological variation on gamma-ray patterns; (ii) its potential to discriminate and identify lithotypes; and (iii) sedimentary processes and related environments of these Permo-Carboniferous strata. The gamma-ray logs were subdivided into three gamma-ray units, according to the total count, concentrations and contents of K, eU and eTh. These gamma-ray units were associated to three depositional units: Glaciolacustrine system with thin-bedded turbidites in the Campo Mourão Formation; and two submarine fans systems (channels, overbanks and lobes) with thick-bedded turbidites systems in the Taciba Formation. Gamma-ray spectrometry allowed distinguishing 'common' shales from black shales, which are often similar in the faciological description in fieldwork. Likewise, carbonate levels were identified as a function of the decrease in gamma-ray concentrations in black shales of the Campo Mourão Formation. The relationship between the radiometric data and the grain size indicated that, in the field, the lithological heterogeneity has a great influence on the ability of the gamma-ray spectrometer to distinguish lithotypes. The eTh/K and eTh/eU ratios were used to infer sedimentary processes and related environments. Through the eTh/eU ratio, a reducing environment, responsible for the precipitation of authigenic uranium in low sedimentation rate deposicional system, was evidenced, discriminating depositional units from different environments.
The sebotrophic effect of pregnancy
Authors: Burton JL , Shuster S , Cartlidge M.
Published: July 2023

The sebum excretion rate (SER) in forehead skin was measured in late pregnancy and 8-20 weeks after delivery in 43 women. There was considerable individual variation but the mean SER during pregnancy was significantly higher than in a control group of non-pregnant women and it showed a large and significant decrease to the control level after delivery. This suggests that a powerful sebotrophic hormone is secreted during pregnancy. The mean SER during pregnancy in women with twins or triplets was no greater than the SER in women with a single foetus. This suggests that the sebotrophic factor of pregnancy is unlikely to be of placental origin, and is in keeping with the idea that the sebotrophic factor may come from the pituitary.
Embryology of the epidermis: ultrastructural aspects. 1. Formation and early development in the mouse with mammalian comparisons
Authors: Weiss LW , Zelickson AS.
Published: July 2023

A detailed light and electron microscopic study of the cellular morphology of developing epidermis in the 7 to 12 day mouse embryo reveals that a single layer of ectoderm is not present until day 8. The 8-day embryonic epithelium is characterized by the presence of microvilli, apical attachment specializations, developing desmosomes and a thin, immature basal lamina. The 9-day embryonic epithelium is flatter and has both an increased number of microvilli on the surface and an increased number of microtubules in association with developing desmosomes. On day 10, numerous developing desmosomes are associated with fine filaments in the regions of the attachment plaques. Occasional peridermal cells are present on day 11. Numerous granules are associated with the inferior cell membranes of the superficial or uppermost cell processes. In the 12-day embryo, the periderm forms a complete layer. A skein of fine filaments is present just inside the basal cell membrane of the germinative cells and microtubules are more abundant in the basal cell cytoplasm.
Suction blister transplantation for leg ulcers
Authors: Hentzer B , Kobayasi T.
Published: July 2023

Application of suction blister transplants to leg ulcers is an alternative symptomatic treatment to split-skin grafting, i.e. "pinch-grafting". Blisters are produced by the suction device Dermovac at a suction pressure of 250-300 mmHg for 1-2 hours. The blister-roofs are cut off at the periphery and placed on the granulation tissue of the ulcer. The healing time for leg ulcers was 10-14 days. Excellent epithelialization was seen in 10 out of 12 ulcers. The advantages of the method are, that it is easy to perform, no scarring is produced, and the procedure is painless.
Anti-basement membrane antibodies in sera from patients without bullous pemphigoid
Authors: Ullman S , Halberg P , Nielsen R.
Published: July 2023

Sera from 208 individuals were examined for antibasement membrane (anti-BM) antibodies by means of an indirect immunofluorescence technique. In sera from patients with bullous pemphigoid 19 of 25 had anti-BM antibodies in titres varying from 80 to 32 000. In 2 of 42 sera from patients with psoriasis, anti-BM antibodies were demonstrated (titres 40-640). Of 58 sera from patients with leg ulcers, antibodies were found in 4 (titres 40-320). Antibodies were found in 2 of 43 patients with cardio-vascular disease (titre 80) and in 1 of 40 control persons (titre 40). Serum from one of the patients with leg ulcers caused a punctate staining pattern unlike the tubular pattern seen in all other positive sera.
Poikiloderma congenitale-an early case of rothmund-thomson's syndrome
Authors: Kristensen JK.
Published: July 2023

A case of congenital poikiloderma is presented. Two types of congenital poikiloderma can be differentiated on the basis of onset of symptoms and configuration of skin lesions, i.e. Rothmund-Thomson's type and Wodniansky's type. The case presented here is of the Rothmund-Thomson's type, but showed only minor abnormalities apart from skin changes and hair loss. A slightly elevated concentration of lysine and cystine was found in the urine of our patient.
Deposits of immunoglobulins and complement in the dermoepidermal junction of patients with anaphylactoid purpura
Authors: Ullman S , Halberg P , Nielsen B , Jorgensen F , Balslov JT.
Published: July 2023

Skin biopsies from 3 patients with anaphylactoid purpura examined by an immunofluorescence technique revealed deposits of immunoglobulins, complement C3, and fibrinogen in the dermo-epidermal junction and in vessel walls of clinically involved as well as uninvolved skin. The deposits in the dermo-epidermal junction are similar to those seen in the skin of patients with systemic lupus erythematosus.
Cyclic adenosine monophosphate, adenyl cyclase and cyclic nucleotide phosphodiesterase in psoriatic epidermis, with a comment on urinary cAMP
Authors: Härkönen M , Hopsu-Havu VK , Raij K.
Published: July 2023

Abstract is not availeble.
Pseudoxanthoma elasticum. An ultrastructural study of oral lesions
Authors: Danielsen L , Kobayasi T.
Published: July 2023

Abstract is not availeble.
Alcohol intake and psoriasis
Authors: Delaney TJ , Leppard B.
Published: July 2023

Abstract is not availeble.
In vitro organ culture of adult human and mouse skin
Authors: Siddiqui AH , Janssen De Limpens , Cormane RH.
Published: July 2023

Abstract is not availeble.
The leukocyte migration test in atopic dermatitis
Authors: Uehara M , Ofuji S.
Published: July 2023

Abstract is not availeble.
Tuberculin sensitivity in BCG-vaccinated children with common warts
Authors: Brodersen I , Genner J , Brodthagen H.
Published: July 2023

Abstract is not availeble.
Interference with healing of rat skin incisions treated with chlorhexidine
Authors: Mobacken H , Wengström C.
Published: July 2023

Abstract is not availeble.
A clinical study on 29 cases of debatable STS and TPI seroreactions in Greenland
Authors: Knudsen EA.
Published: July 2023

Abstract is not availeble.
The effect of cationic triphenylmethane dye (crystal violet) on rabbit granulation tissue. Oxygen consumption and RNA and protein synthesis in tissue slices
Authors: Mobacken H , Ahonen J , Zederfeldt B.
Published: July 2023

Abstract is not availeble.
Aspects of the Odland bodies in the synthesis of keratohyalin
Authors: Lagerholm B , Frithz A.
Published: July 2023

Abstract is not availeble.
Immunological tolerance and dermal eosinophilia induced in dinitrochlorobenzene-sensitized guinea pigs
Authors: Skog E , Wahlberg JE.
Published: July 2023

Abstract is not availeble.
HL-A-antigens and psoriatic arthritis
Authors: Zachariae H , Hjortshøoj A , Kissmeyer-Nielsen F , Svejgaard A , Svejgaard E , Zachariae E.
Published: July 2023

Abstract is not availeble.
Studies on tryptophan catabolism in acrodermatitis enteropathica
Authors: Stachow A , Papuzinski M , Zalewski T , Skiendzielewska A.
Published: July 2023

Abstract is not availeble.
Hyperkeratosis lenticularis perstans (Flegel)
Authors: Neumann E , Nilsson R , Paul U.
Published: July 2023

Abstract is not availeble.
Letter: Etiology of erythropoietic protoporphyria, and protection of photosensitive subjects
Authors: Fusaro RM , Johnson JA.
Published: July 2023

Abstract is not availeble.
Aryl-sulfatase activity of membrane-coating granules with particular reference to their origin
Authors: Takaki Y.
Published: July 2023

Abstract is not availeble.
Immunofluorescent studies of the skin in mixed cryoglobulinaemia and Schönlein-Henoch purpura
Authors: Giannetti A , Serri F , Bernasconi C.
Published: July 2023

Immunofluorescence investigations in patients with mixed cryoglobulinaemia, Sch√∂nlein-Henoch purpura and purpuric allergic reaction with disseminated intravascular coagulation have been performed. In the lesional skin from 8 patients with mixed cryoglobulinaemia, granular vascular deposits of immunoglobulins of the same classes as those of the circulating cryoglobulins were detectable in all cases; complement and fibrinogen were concomitantly present. In the unaffected skin, IgM and complement were detected in the walls of the capillaries. In the early purpuric lesions from 6 patients with Sch√∂nlein-Henoch syndrome and from a patient with diseeminated vascular coagulation from acute allergic reaction to phenylbutazone, deposits of fibrinogen occurred mainly in the vessel walls.
The spontaneous regression of keratoacanthoma in man
Authors: Ramselaar CG , Van der Meer JB.
Published: July 2023

This study was undertaken to search for immune mediated mechanisms which could possibly be involved in the spontaneous regression of keratoacanthomas. In eleven patients with solitary keratoacanthoma, immunofluorescence studies did not reveal significant staining patterns, while skin tests, using autologous extracts of keratoacanthomas, were not compatible with true delayed cutaneous hypersensitivity reactions.
Intestinal absorption of L-tryptophan in scleroderma
Authors: Stachow A , Jablońska S , Skiendzielewska A.
Published: July 2023

The purpose of this investigation was to study the intestinal absorption of L-tryptophan and to assess the absorptive function of the intestine in scleroderma. The oral L-tryptophan loading test was performed in 31 cases of systemic scleroderma (progressive systemic sclerosis, PSS) and 3 cases of localized scleroderma. Serum levels of tryptophan and urinary excretion of indole-acetic acid (IAA) and indican (IS) were determined in order to assess intestinal absorption of tryptophan. In 10 cases the D-xylose test and in 4 cases Schilling's test was also performed. Furthermore, in vitro binding of L-tryptophan by plasma proteins in PSS and in other skin diseases as controls was studied. The normal increase in serum tryptophan after loading was noted in 17 cases (in 14 cases of PSS with a mild, slow progression in 3 cases of PSS with a severe, rapidly progressing course). In 10 of these cases, urinary excretion of IAA was higher than normal and in normal and in 3 cases excretion of urinary IS was also above normal. On the other hand, in 14 cases of severe, rapidly progressing PSS and in 2 of 3 cases of widespread linear scleroderma, serum levels of tryptophan were markedly depressed after loading, while urinary excretion of IAA and IS was normal. In all 4 cases studied, Schilling's test was normal, and only in 2 of 10 cases of PSS was the D-xylose test abnormal. It is concluded that in the majority of cases of PSS, intestinal absorpiton of tryptophan is normal as also is the absorptive function of the intestine. The slight rise in serum tryptophan after loading in some cases of PSS may be a result of increased binding of tryptophan by albumin.
Letter: An immunohistochemical study of the skin of healthy individuals
Authors: De la Faille-Kuyper EH , De la Faille H , Van der Meer JB.
Published: July 2023

de la Faille-Kuyper EH, de la Faille H, van der Meer JB.
Immunoglobulin-bearing cells in leprosy
Authors: Faber WR , Leiker DL , Cormane RH.
Published: July 2023

Peripheral blood lymphocytes of 28 untreated and 17 treated patients with different types of leprosy were investigated for the occurrence of immunoglobulin (Ig) bearing cells by means of a smear method. Seven healthy Africans served as controls. In a later stage a complementary study was performed on 6 tuberculoid and 6 lepromatous leprosy patients by means of a suspension method. The immunofluorescence technique was used for the detection of Ig-bearing cells, In tuberculoid leprosy an increase of Ig-bearing cells seems to occur during treatment, predominantly expressed by an increase in IgD-bearing cells. In lepromatous leprosy no increased percentages of Ig-bearing cells were observed.
Benign and malignant proliferative response. Dermal infiltration, origin and importance
Authors: Steigleder GK.
Published: July 2023

Lymphoreticular infiltration (LRI) is the most common type of dermal infiltration. The LRI is made up of two main components: (i) a dermal skeleton, and (ii) the infiltration in a strict sense. (i) The dermal skeleton consists of the blood vessel involved, most probably a post-capillary venule, and activated fibroblasts (Fig. 3). The activated fibroblasts contain "paraplasmatic granules" in their processes (Fig. 4). Since the fibroblasts are in mutual contact by their ramifications (Fig. 3), they are reticulum cells by definition (Bessis). In our opinion they are the only local reticulum cells in the dermis. They are not stem cells, nor do they belong to the reticulo-endothelial system and they do not give rise to histiocytes. (ii) In the skeleton of LRI, other cells infiltrate, predominantly monocytes and lymphocytes. The LRI may specialize and contain various amounts of neutrophilic, basophilic, or eosinophilic leukocytes and plasma cells. If enough B-lymphocytes and plasmacells are involved, abnormal globulins may be produced (e.g. syphilis II). The lymphomas are considered to be malignant proliferative disorders of LRI-type. LRI is found in allergic spreading reactions mediated by stimulated lymphocytes. A similar spreading of lymphocytes is to be expected if the allergen sensitizes a lymphocyte with neoplastic information (e.g. tumor virus) (Fig. 6). The degree of dedifferentiation and the response of the organism to the dedifferentiated lymphocytes is the reason for the variety of lymphomas.
Phototoxic reaction to chlorpromazine as studied with the quantitative mouse tail technique
Authors: Ljunggren B , Möller H.
Published: July 2023

A quantitative in vivo technique for the study of the phototoxic reaction to systemic chlorpromazine has been developed, based on the increasing tissue fluid content of the albino mouse tail. A maximum increase in tissue fluid of about 25% was registered 24 hours after starting the long-wave ultraviolet light exposure. The minimum phototoxic dose of chlorpromazine was 2.5 mg/kg.
Keratinized cells as a possible yellow-stain receptor for gold-orange
Authors: Höglund A.
Published: July 2023

Using a previously described staining procedure, it was found that gold-orange stains some epithelial cells yellow, both in skin sections and in cytologic smears from skin and various other epithelia. A correlation seems to exist between the degree of keratinization and the yellow colour obtained with this staining method.
Keratodermia blennorrhagica in a woman with relapsing polychondritis
Authors: Hammar H.
Published: July 2023

Abstract is not available.
Cytolytic degeneration of keratinocytes adjacent to Langerhans cells in pityriasis rosea (Gibert)
Authors: Takaki Y , Miyazaki H.
Published: July 2023

Unique cytolytic degeneration of keratinocytes adjacent to Langerhans cells was observed in five cases of pityriasis rosea (Gilbert). In the cytolytic area, the normal keratinocyte structures were absent except for free ribosomes. In addition, a similar cytolytic part of a keratinocyte was enveloped by the elongated dendrites of the Langerhans cell and was detected within its cytoplasm. The significance of these findings is discussed with respect to anticytoplasmic antibodies in the sera of patients with pityriasis rosea.
On cell-mediated immunity in acne conglobata
Authors: Rajka G.
Published: July 2023

In 25 of 35 cases of acne conglobata, a reduction in or lack of delayed reactivity was found by intracutaneous tests with a battery of antigens. On the basis of these findings as well as of normal T-cell function in lymphocyte culture and of negative Kveim-tests (in three cases), the possible immunological mechanisms are discussed.
Crohn's disease--non-caseating granulomas on the legs
Authors: Witkowski JA , Parish LC , Lewis JE.
Published: July 2023

A 27-year-old black man with Crohn's disease and nodules on the legs is described. Such nodules constitute one of three types of cutaneous manifestations which have a histological picture of a non-caseating granuloma. The two other varieties of skin lesions described are: that resulting from a direct spread from the gastrointestinal tract, and that resulting from spread over contiguous skin.
Studies on cold insoluble globulin in dermatological patients. II. Its immunochemical quantitation in citrated plasma in a group of unselected dermatological inpatients
Authors: Fyrand O.
Published: July 2023

Cold insoluble globulin (CIG) is the main non-clottable protein of heparin precipitable fraction from dermatological patients. CIG is a glycoprotein with a molecular weight of about 440 000. It is found on cell membranes on fibroblasts and is a normal protein of human plasma and serum. Levels of CIG in citrated plasma are sex- and age-dependent, but the origin and its physiological significance is unknown. In plasma of 294 dermatological patients, levels of CIG were elevated in eczema contactum allergicum (males and females 30-49 years), psoriatic arthritis (females 50 years and above) and were depressed in dermatitis herpetiformis (males 30-49 years).
Systemic sarcoidosis with necrobiosis lipoidica-like scalp lesions
Authors: Andersen KE.
Published: July 2023

A 78-year-old woman is described, having systemic sarcoidosis for 15 years, involving the lungs, lymph nodes and the skin. Over the last 6 years she developed a progressive cicatricial alopecia with histologic changes of the
Deposition of fibrinogen (FR-antigen) in skin diseases. III. Synovial joint membranes in psoriatic arthritis
Authors: Fyrand O , Mellbye OJ.
Published: July 2023

Synovial joint membranes obtained by synovectomy in open bloodless fields were examined for FR-antigen (fibrinogen/fibrin-related antigen) in 15 patients with psoriatic arthritis (ps.a.) and in a control group of 5 patients with meniscal tears. All frozen and paraffin sections from ps.a. demonstrated FR-antigen at the synovial lining. In the tissue it was located at the surface and in cytoplasm of the superficial synovial cells. In the control group, FR-antigen was present in all frozen samples as a thin layer at the synovial lining surface, but absent in the paraffin sections. The presence of FR-antigen may contribute to the further development of the Inflammatory changes of the arthritis.
Iron absorption in patients with dermatitis herpertiformis
Authors: Kastrup W , Magnusson B , Mobacken H , Swolin B , Sölvell L.
Published: July 2023

Iron absorption has been studied in patients with dermatitis herpetiformis (DH). Four patients out of 20 had iron deficiency, defined as absence of or only
Photodynamic inactivation of verrucae vulgares. II
Authors: Veien NK , Genner J , Brodthagen H , Wettermark G.
Published: July 2023

Photodynamic inactivation therapy, consisting of a double-blind, paired comparison treatment schedule, was used in treating 56 patients for recalcitrant, symmetrical verrucae vulgares. 0.1% proflavine in 100% dimethylsulphoxide (DMSO) and 0.1% neutral red in 100% DMSO were used as active dyes, and 1% picric acid in 100% DMSO and 1% color ruber in 100% DMSO and 1% color ruber in 100% DMSO served as corresponding placebos. A Westinghouse sunlamp and black light were used to irradiate the warts dyed with proflavine and its placebo, and the warts dyed with neutral red and its placebo were irradiated with an ordinary light bulb (Osram 588597). 50 patients completed the treatment. 10 of the 27 patients treated with proflavine and 10 of the 23 patients treated with neutral red were cured by the end of an 8 week period, with the warts disappearing simultaneously from the actively as well as the placebo-treated side. Complement fixing antibodies against wart virus were detected in one of the cured patients and 2 who were treatment failures.
Levamisole in a double-blind study: no effect on warts
Authors: Schou M , Helin P.
Published: July 2023

Levamisole is reported to restore delayed hypersensitivity, when this is depressed. On the assumption that multiple warts, resistant to local treatment, are indicative of some immune deficiency, we chose levamisole for the treatment of warts. The dose, 150 mg daily in 3 days every second week, was given to 49 patients who had common warts and to 50 patients who had condyloma (venereal warts). After 6 weeks of double-blind study, most of the patients underwent open levamisole treatment. However, the levamisole group failed to show enhanced wart regression compared with the control group. No inter-group difference could be detected as regards change in delayed hypersensitivity after levamisole treatment, when measured by the mantoux response.
Prostaglandin E2 in blister fluid of bullous diseases and experimental suction blisters
Authors: Strandberg K , Hägermark O.
Published: July 2023

Prostaglandin(PG)-like activity in the fluid of spontaneous and suction blisters was measured by bioassay on isolated guinea-pig colon after acidic lipid extraction. The fluid from spontaneous blisters in 15 patients with various bullous dermatoses, such as pemphigoid, porphyria cutanea tarda, erythema multiforme, contact dermatitis, X-ray dermatitis, all contained measurable amounts of activity, varying from 0.4 to 54 ng/ml, expressed as PGE2-activity. From 4 patients with pemphigoid, samples of fluid were collected, adequate to permit of analysis regarding the identity of the spasmogenic material. In silicic acid column chromatography, thin-layer chromatography, and in reversed phase partition chromatography, the major part of the biological activity co-chromatographed with 3H-PGE2. In one patient part of the activity coincided with PGF2alpha. The PG-like activity of experimental suction blisters was found to be significantly higher in patients with dermatitis herpetiformis than in control and psoriasis patients. The appearance of PGs in blister fluid is compatible with a role as chemical mediator involved in blister formation.
PBS-soluble substances with blood group activity from human epidermis and dermis
Authors: Diaz LA , Calvanico NJ , Tomasi  Jr TB , Jordon RE.
Published: July 2023

Phosphate-buffered saline (PBS) soluble extracts of human epidermis and dermis from secretor donors contain products with blood group antigenic activity. The predominant blood group in a sample was the same as the red cell phenotype of the donor. H substance activity was present in all PBS-soluble products (from A, B and O donors). By gel filtration chromatography on a Bio-Gel A-1.5 m column; the epidermal and dermal PBS-soluble blood group substances fractionate in the void volume.
Acid alpha-naphthyl acetate esterase staining of T lymphocytes in human skin
Authors: Hovmark A.
Published: July 2023

T lymphocytes were stained in order to disclose alpha-naphthyl acetate esterase activity (ANAE staining) by adopting the method described by Mueller et al. In ANAE-staining of frozen sections from human lymph nodes, more than 90% of the lymphocytes in paracortical areas (T cell areas) were ANAE-positive, but in cortical follicles (B cell areas) less than 5% of the cells were positive. Lymphocytic infiltrations in various dermatoses (lichen ruber planus, psoriasis, SLE, atropic dermatitis, erythema multiforme, poikiloderma atrophicans vasculare, and S√©zary syndrome) were investigated. A high percentage of ANAE-positive lymphoid cells (greater than 80%) was found in most cases. One patient with chron. lymphatic leukaemia, however, had a smaller proportion of ANAE-positive lymphocytic cells in an erythema multiforme skin infiltrate. ANAE staining seems to be an easy method for the identification of T lymphocytes in skin sections. The results of this investigation support the hypothesis that T lymphocytes have an affinity to skin.
Pachyonychia congenita Jadassohn-Lewandowsky: a disorder of keratinization
Authors: Thormann J , Kobayasi T.
Published: July 2023

A 15-month-old boy with pachyonychia congenita is described. The patient also had follicular keratosis, leukokeratosis of the tongue, and blisters on the soles. Histopathological examination of the follicular keratosis showed hyperkeratosis and acanthosis. Horny plugs were located in sweat pores. By electron microscopy abnormal keratinization was demonstrated.
Isolation and characterization of soluble epidermal antigens reactive with pemphigus antibodies
Authors: Miyagawa S , Hojo T , Ishii H , Yoshioka J , Sakamoto K.
Published: July 2023

The antigenic substance reactive with pemphigus antibodies was isolated from the soluble component of guinea pig epidermis by affinity chromatography. The substance was a protein of molecular weight 18 000 and consisted of RNA and hexose.
Demonstration of glycocalyx in the sweat gland
Authors: Gibiński K , Jonek JJ , Grzybek H , Panz B
Published: July 2023

Skin specimens were taken without any anaesthesia from four volunteers before and after a 1 hour's exposure to heat. No glycocalyx could be demonstrated in the resting gland, but it usually appeared, however, after one hour of thermal sweating--although not in all the sections. The possible implication of this phenomenon is briefly discussed and new problems outlined.
Dose-dependent effect of topical corticosteroids on blood flow in human cutaneous tissue
Authors: Kristensen JK , Wadskov S , Henriksen O
Published: July 2023

In seven healthy subjects the dorsum of the hand was treated with beta-methasone valerate cream in increasing concentrations, from 0.1 to 1.0%, and with hydrocortisone butyrate 0.1% with or without plastic occlusion. Under conditions of controlled room temperature, blood flow in treated, placebo-treated, and untreated cutaneous tissue was measured using the local 133Xenon wash-out technique. Placebo creams did not affect cutaneous blood flow, but beta-methasone valerate 0.1% reduced blood flow and 1.0% increased it. An increase in blood flow was also observed after use of hydrocortisone butyrate under plastic occlusion. The results indicate a dual effect of potent corticosteroids on cutaneous blood flow.
The effect of transfer factor on cystic acne
Authors: Gröhn P , Kuokkanen K , Krohn K
Published: July 2023

A chromatographically purified component of human dialysable transfer factor, previously described as causing a non-specific stimulation of cell-mediated immunity, was used as a therapeutic agent in three cases of stage IV cystic acne. The treatment caused a marked strengthening of skin test responses and had a promising effect on skin eruption in each case.
Deposits of complement and immunoglobulins in dermal and synovial vessels in psoriasis
Authors: Ullman S , Halberg P , Hentzer B , Sylvest J
Published: July 2023

Deposits of complement C3 and/or immunoglobulin were found in the vessel walls and/or at the dermal-epidermal junction in skin lesions of all of 11 patients with psoriatic arthritis and guttate psoriasis. Similar deposits were seen in 6 out of 15 patients with psoriasis vulgaris. Synovial tissue available from 2 patients revealed deposits in the vessel walls.