bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative study of liquid crystal variable retarder with rubbed polyimide and SiO2 thin films by glancing angle deposition
Authors: Ou Shaozhong , Wang Jianguo , Zhao Yuan’an , Liu Xiaofeng , Mo Zhichang , Wang Kun , Tao Chunxian
Published: March 2023

A comparative study on the optical, morphological and laser-induced damage characteristics of rubbed polyimide, SiO2 thin films by glancing angle deposition, and the corresponding liquid crystal (LC) retarders, is presented in this paper. SiO2 inorganic thin films were prepared with a deposition angle of 45[Formula: see text], and traditional polyimide (PI) films were prepared by spin coating and rubbing. The experimental results indicate that the SiO2 thin films have a good transmittance and resistance to laser damage. The transmittance of the SiO2 thin films was above 92% in the wavelength range 400–1200 nm, and that of the corresponding LC retarder was approximately 90% in the wavelength range 800–1200 nm. The laser-induced damage threshold of the SiO2 thin films reached 32.6 J/cm2, and that of the corresponding LC retarder was 1.84 J/cm2. These results are better than those of the PI alignment films. SiO2 thin films have potential for use in the LC optical devices for laser applications.
Stochastic Analysis of Impact Viscoelastic Energy Harvester with Unilateral Barrier Under Additive White Noise Excitation
Authors: Yang Yong-Ge , Zhou Hui-Juan , Huang Mei-Ling , Sun Ya-Hui
Published: March 2023

Vibration impact is often used in the piezoelectric energy harvesting (PEH) system to increase the effective bandwidth of the harvester. Viscoelastic materials have been used successfully to mitigate vibration problems in various types of mechanical systems such as buildings, cars, aircraft and industrial equipment. However, less research has been done on the energy harvesting system with impact and viscoelastic force driven by random excitation. Stochastic response of an impact PEH system with viscoelastic force under Gaussian white noise excitation is investigated in this paper. Firstly, by transforming the variables, viscoelastic force can be substituted with the stiffness and damping terms to get an approximately equivalent system without viscoelastic term. Secondly, the approximate analytical solutions are acquired by the stochastic averaging method and nonsmooth coordinate transformation. The validity of this theoretical approach is confirmed by comparing the analytical solutions with the numerical solutions derived from the Monte Carlo method. Then, the effect of noise intensity and nonlinear damping coefficient on the stochastic response of the system is discussed. It is concluded that the restitution coefficient, viscoelastic component, relaxation time and linear damping coefficient can induce the occurrence of stochastic P-bifurcation. Finally, the roles of system parameters on the mean square voltage and average output power of the energy harvester are investigated respectively.
A Conservative Chaotic Oscillator: Dynamical Analysis and Circuit Implementation
Authors: Parthasarathy Sriram , Natiq Hayder , Rajagopal Karthikeyan , Zavareh Mahdi Nourian , Nazarimehr Fahimeh
Published: March 2023

This paper introduces a new 3D conservative chaotic system. The oscillator preserves the energy over time, according to the Kaplan–Yorke dimension computation. It has a line of unstable equilibrium points that are investigated with the help of eigenvalues and also numerical analysis. The bifurcation diagrams and the corresponding Lyapunov exponents show various behaviors, for example, chaos, limit cycle, and torus with different parameters. Other dynamical properties, such as Poincaré section and basin of attraction, are investigated. Additionally, an oscillator’s electrical circuit is designed and implemented to demonstrate its potentiality.
Hosoya polynomials and corresponding indices of aramids
Authors: Rashid Sidra , Sheikh Umber , Sattar Ayesha , Pincak Richard
Published: March 2023

Aramids are man-made high performance fibers admitting useful industrial applications. Aramids can be classified into para-aramids and meta-aramids. Kevlar is a para-aramid and Nomex is a meta-aramid. This work is devoted to compute the empirical formula for the Hosoya polynomial of these aramids. The closed form of a number of distance-related topological indices (TIs) is the famous distance-based Hosoya polynomial. These are Weiner, hyper-Weiner and Tratch–Stankevitch–Zafirov indices. Results exhibit that para-aramid and meta-aramid possess different Hosoya polynomials and corresponding distance-based TIs. Further, distance-related TIs derived from Hosoya polynomial for the para-aramid admit larger values as compared to those of the meta-aramid.
Demi-complementation on distributive lattices
Authors: Sambasiva Rao M.
Published: March 2023

The notion of demi-complementation is introduced on distributive lattices. Certain important properties of demi-complemented distributive lattices are investigated. Some equivalent conditions are given for every demi-complemented lattice to become a pseudo-complemented lattice. The notion of demi-implication algebras is introduced and their properties are investigated. Some applications of demi-complementation to implication like algebras are studied.
Mechanical Mathematicians
Authors: Bentkamp Alexander , Blanchette Jasmin , Nummelin Visa , Tourret Sophie , Vukmirović Petar , Waldmann Uwe
Published: March 2023

A new generation of automatic theorem provers eliminate bugs in software and mathematics.
POLY(Amidoamine) Dendrimer-Induced 3D Crosslinked Network Binder For LiFePO4 Cathode: Endowing Battery With Superior Cycling Stability
Authors: Hu Yuqin , Wang Cheng , Zhu Guobin , Xu Jing , Wang Luoxin , Wang Hua , Cheng Chunzu
Published: March 2023

The electronic and ionic conductivity inside electrode play a decision role in cell performance of lithium-ion batteries (LIBs). However, traditional polymer binder connecting the conductive network for active material often tends to lose its original structure and function after the immersion of electrolyte. This will make the conductive network collapse, thus affecting charge/discharge capacity and cycle stability of LIBs. Therefore, in this paper, Poly(amidoamine) (PAMAM) induced three-dimensional (3D) crosslinked polymer was designed and applied as binder for LIBs cathode. Compared with conventional linear Polyvinylidene fluoride (PVDF) binder, the 3D binder exhibits better bonding ability and electrolyte affinity, which respectively bring superior electronic and ionic conductivity for LiFePO4 cathode. So that the slighter polarization and better C-rate capability (140 mAh g−1 in 2C discharge) are achieved. In addition, the crosslinked network constructed in binder provides smooth and stable surficial morphology for electrode through stronger own strength and adhesion with substrate (average 7.69 N), which finally leads to improved cycling performance (98% retention after 250 cycles). Clearly, this 3D crosslinked polymer will bring new breakthrough for binder during the development of higher power LIBs.
Reversing the Chemical and Structural Changes of Prussian White After Exposure to Humidity to Enable Aqueous Electrode Processing for Sodium-ion Batteries
Authors: Hartmann Louis , Deshmukh Jay , Zhang Libin , Buechele Sebastian , Metzger Michael
Published: March 2023

Prussian White is a promising active material for the positive electrode of sodium-ion batteries as it is comprised of Na, Mn, Fe, C, and N and thus offers high sustainability and low cost. However, exposure of Prussian White to moisture results in chemical changes due to the formation of surface contaminants, as well as structural changes due to the absorption of water into the bulk crystal structure. Here we report an analysis of the formation rate of surface contaminants and bulk water absorption by weight tracking, infrared spectroscopy, and X-ray diffraction over extended periods of storage in high relative humidity air for fully sodiated Na1.8Mn0.8Fe0.2[Fe(CN)6]0.9 and partially sodiated Na1.3Mn0.8Fe0.2[Fe(CN)6]0.9. Fully sodiated Prussian White gains almost 20% in mass due to the formation of interstitial water during 20 h of storage in 100% relative humidity at 25 °C. Surface hydroxides and carbonates are found after storage and a structural change from the rhombohedral to a monoclinic crystal structure is observed. It is found that vacuum drying of Prussian White powder or electrodes at 150 °C can remove the majority of interstitial water and restore the rhombohedral crystal structure, but not remove surface contaminants. Prussian White immersed in water during aqueous electrode processing also shows interstitial water and a monoclinic crystal structure, but no surface contaminants. This suggests that aqueous electrode processing of Prussian White is feasible when effective drying strategies are employed. Indeed, Prussian White electrodes made from H2O-based slurries with CMC/NaPAA binder vacuum-dried at 150 °C show higher specific capacity and similar capacity retention in full cells as Prussian White electrode made from NMP-based slurries with PVDF binder.
Lithium-ion Differential Thermal Analysis Studies of the Effects of Long-Term Li-ion Cell Storage on Electrolyte Composition and Implications for Cell State of Health
Authors: Bauer Michael K. G. , Harlow Jessie , Hynes Toren , Dahn J. R.
Published: March 2023

Li-ion cells being developed for long lifetime applications are often subjected to storage tests at various states-of-charge and various temperatures. Storage is interrupted from time to time for reference performance tests so that cell capacity and impedance can be checked. These reference performance tests give no information about any compositional changes that may have occurred in the electrolyte. Lithium-ion differential thermal analysis applied to cells after years of storage can be used to determine if the electrolyte has changed significantly due to unwanted reactions with the electrode materials or if little to no change has occurred. Here, Li-ion differential thermal analysis is used to study electrolyte changes in a more-or-less “yes/no” manner for single crystal NMC532/graphite cells stored between 3.67 and 4.3 V at 20, 40 and 55 °C for up to five years. Such measurements can be used to give confidence about lifetime predictions. Several such cells are detailed here, with correlation between degree of cell degradation and degree of change in electrolyte composition. Relationships are shown between degradation and evolution of state of electrolyte in elevated temperature and voltage storage experiments.
Simulated patient videos to supplement integrated teaching in competency-based undergraduate medical curriculum
Authors: Nayak Kirtana Raghurama , Nayak Veena , Punja Dhiren , Badyal Dinesh K. , Modi Jyoti Nath
Published: March 2023

In this study, we have introduced linker cases to teach clinical correlation of basic sciences for integrated modules in the competency-based undergraduate medical curriculum. The novelty of our study is the inclusion of simulated patient video that was internally prepared and validated to supplement linker clinical paper cases in integrated modules.
Inhibitory effect of sulfur dioxide inhalation on Hering–Breuer inflation reflex in mice: role of voltage-gated potassium channels
Authors: Chan Nai-Ju , Hsu Chun-Chun , Lin You Shuei , Lin Ruei-Lung , Lee Lu-Yuan
Published: March 2023

This study demonstrated that inhaled sulfur dioxide completely and reversibly abolished the activity of vagal bronchopulmonary slowly adapting receptors, significantly inhibited the apneic response to lung inflation, and induced slow deep breathing in anesthetized mice. More importantly, our results further suggested that this inhibitory effect was mediated through an action of sulfur dioxide and its derivatives on the voltage-gated potassium channels expressed in the slowly adapting receptor sensory neurons innervating the lung.
An Improved Feedforward-Robust Algorithm for Active Vibration Control of Helicopter Maneuver Flight
Authors: Qin Yifan , Lu Yang , Yue Huiyu
Published: March 2023

To solve the problem of secondary path mutation and external disturbance abrupt changes during helicopter maneuver flight, the previous research proposed a hybrid active vibration control law. To improve the engineering applicability, the original algorithm is ameliorated to the least mean square-input-output-based robust (LMS-IOBR) algorithm. The system model within the target frequency band can be identified through the input-output data to avoid constructing complex state observers. In addition, the output form of the feedback controller is constructed by an autoregressive moving average model with extra input, which is beneficial to improve operational efficiency. Numerical simulations demonstrate that compared with the original algorithm, controller real-time computation can be reduced by 52% with control effects guaranteed at the same time. Furthermore, to verify the effectiveness and adaptability of LMS-IOBR, multi-input multioutput vibration control experiments are carried out on a specially developed simple platform for simulating helicopter maneuver states. Comparative tests in various typical states are performed between the LMS-IOBR and the multichannel least mean square algorithm. Under the complex circumstances of simulating continuous subduction uplift, the peak response of closed-loop system attenuates by 80% and 70%, and the vibration of two points is reduced to 15% and 20%, respectively, within 3 s. The experimental results demonstrate that the proposed LMS-IOBR algorithm shows stronger transient adaptability and robustness against external disturbance excitation and secondary channel mutation in helicopter maneuver flight.
Outcomes of Endovascular Treatment for Posterior Circulation Stroke According to the Underlying Pathologic Mechanism: A Retrospective Single-Center Analysis
Authors: Shang Xianjin , Yang Ke , Guo Yapeng , Su Liwei , Yang Qian , Zhou Zhiming
Published: March 2023

Objectives. This study investigated the functional outcomes and safety of endovascular treatment in patients with posterior circulation stroke according to whether the underlying mechanism was arterial embolism or intrinsic atherosclerosis. Materials and Methods. A total of 108 consecutive patients with posterior circulation ischemic stroke who received endovascular treatment between January 2018 and December 2021, 58 with arterial embolism and 50 with intrinsic atherosclerosis, were identified. The overall and basilar artery occlusion subgroup analyses were retrospectively conducted between the two study groups using a logistic regression model. Results. The rate of successful reperfusion (modified Thrombolysis in Cerebral Infarction score 2b–3) was comparable in the embolism versus intrinsic group (96.6% versus 90.0%; adjusted odds ratio [aOR] 0.73, 95% confidence interval [CI] 0.01–42.74;

P
=
0.88

). There was no significant difference in the frequency of a moderate outcome between the two groups (modified Rankin Scale [mRS] score 0–3: 43.1% versus 58.0%; aOR 0.63, 95% CI 0.15–2.50;

P
=
0.51

), frequency of a favorable outcome (mRS 0–2: 39.7% versus 38.0%; aOR 1.59, 95% CI 0.37–6.70;

P
=
0.52

), the 90-day mortality rate (34.5% versus 26.0%; aOR 2.31, 95% CI 0.50–10.63;

P
=
0.28

), or frequency of symptomatic intracranial hemorrhage (6.9% versus 2.0%, respectively;

P
=
0.37

). The subgroup analysis in patients with basilar artery occlusion found no significant between-group difference in any of the abovementioned clinical outcomes (all

P
>
0.05

). Conclusion. This study indicated that the mechanism of posterior circulation stroke had no significant effect on the functional outcomes after endovascular treatment or on procedural safety.
The Stable Equilibrium Analysis of Nonlinear Renewable Resource Stock Evolution
Authors: Güven Gökhan , İnançli Selim
Published: March 2023

This paper provides the formal proofs of propositions concerning the stability analysis of steady-state equilibrium in autarky with open-access renewable resources. We assume three different resource environments in which excessive harvesting, pollution, and simultaneous coexistence of these interacting pressures on resource stocks are considered. The propositions mentioned on J.A. Brander and M.S. Taylor, Open access renewable resources: trade and trade policy in a two-country model, Journal of International Economics, 44 (2), 181–209, 1998; B.R. Copeland and M.S. Taylor, Trade, spatial separation, and the environment, Journal of International Economics, 47 (1), 137–168, 1999; and H. A. Rus, Renewable resources, pollution and trade, Review of International Economics, 24 (2), 364–391, 2016 have been shown only on the diagrams and also implicitly explained. This paper aims to contribute the renewable open-access resources literature by providing formal solutions of stable equilibrium analysis in a closed economy within the long run.
Vision‐Related Quality of Life in Primary Angle‐Closure Glaucoma Patients with or without Visual Field Dysfunction
Authors: Ma Pingping , Liu Yingru , Su Yufang , Yang Yajun
Published: March 2023

Purpose. To evaluate the association between visual‐related quality of life (VRQoL) and visual field (VF) loss in patients with primary angle‐closure glaucoma (PACG). Methods. In this case‐control study, a total of 79 patients with PACG (with or without VF detects) and 35 healthy controls were included. The patients underwent the 25‐item National Eye Institute Visual Functioning Questionnaire (NEI VFQ‐25), clinical examination, and VF testing. VF defects were identified by simplified Hodapp’s classification. NEI VFQ‐25 scores were compared between the three groups. Results. No significant differences were found in gender, VFQ rating for “composite score” and “color vision” between the three groups. PACG patients with VF loss were most likely to be older and had lower best corrected visual acuity (BCVA), spherical equivalent (SE), mean deviation (MD), and visual field index (VFI), but higher pattern standard deviation (PSD) (all P < 0.05). Furthermore, patients with VF loss had significantly lower NVE‐VFQ‐25 subscale scores for general health, general vision, ocular pain, near activities, distance activities, social functioning, mental health, role difficulties, dependency, driving, and peripheral vision than PACG patients without VF loss and healthy controls (all P < 0.05). VFI (β = 1.498, P = 0.003) and MD (β = −3.891, P = 0.016) were significantly correlated with Role Difficulties scores. Additionally, PSD was significantly correlated with Peripheral Vision scores (β = −1.346, P = 0.003). Conclusions. PACG patients with VF loss reported lower NEI VFQ‐25 composite and subscale scores. VF indices including VFI, MD, and PSD were strongly correlated with VRQoL as assessed by NEI VFQ‐25; thus, VRQoL may be significantly impacted by glaucomatous VF defects.
A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
Authors: Ding Nan , You A-Bin , Yang Hu , Hu Guo-Sheng , Lai Chun-Ping , Liu Wen , Ye Feng
Published: March 2023

Purpose:

The oncogenic role of circular RNAs (circRNA) has been well studied in cancers including colorectal cancer. However, tumor-suppressive circRNAs and the mechanism through which they exert their antitumor effects remain largely unknown. We aim to find out the critical tumor-suppressive circRNAs and their possibility to serve as gene therapy targets.

Experimental Design:

circRNA sequencing, gain-of-function and loss-of-function experiments, and transcriptomic analysis were performed to find tumor-suppressive and antitumor immunity effects of circRERE. Molecular biology experiments were conducted for mechanism exploration. Finally, we conducted adeno-associated virus (AAV) to deliver circRERE (circRERE-AAV) and evaluated circRERE-AAV alone and in combination with anti-PD-1 antibody in C57BL/6J mice bearing subcutaneous MC38 tumors.

Results:

circRERE is lowly expressed in colorectal cancer. Overexpression of circRERE inhibits the malignant behaviors of colorectal cancer in vitro and in vivo, while knockdown exhibits the opposite effects. The expression of circRERE is regulated by EP300, a histone acetyltransferase downregulated in colorectal cancer as well. Mechanistically, circRERE acts as a competitive endogenous RNA to sponge miR-6837-3p to upregulate MAVS expression, thereby activating type I IFN signaling and promoting antitumor immunity. Delivery of circRERE-AAV elicits significant antitumor effects, and combination treatment with circRERE-AAV and anti-PD-1 antibody exhibits synergistic effects on tumor growth in preclinical models of colorectal cancer.

Conclusions:

These results uncover modulatory axis constituting of EP300/circRERE/miR-6837-3p/MAVS and its essential roles in antitumor immunity, and demonstrate that circRERE-AAV might represent a new therapeutic avenue to prime immune responses and boost the effects of immunotherapy in clinic.
Outcome of Renal Function after Laparoscopic Pyeloplasty in Children with High-Grade Hydronephrosis
Authors: Zhang Lingling , Xu Hongye , Feng Yikun , Wang Xiaoqing , Du Guoqiang , Wu Rongde , Liu Wei
Published: March 2023

Introduction: This study aimed to analyze the changes in differential renal function (DRF) after laparoscopic pyeloplasty in children with high-grade hydronephrosis and factors influencing DRF improvement. Methods: We reviewed the clinical data of unilateral ureteropelvic junction obstruction (UPJO) patients with SFU grade IV who underwent laparoscopic pyeloplasty between February 2018 and October 2020. The patients were divided into two groups: DRF improvement ≥5% (group 1) and DRF improvement <5% (group 2). Preoperative, operative, and postoperative parameters were included in the statistical analysis in both groups. Results: A total of 29 patients with a median age of 6 months were included. The preoperative DRF in group 1 was significantly lower than that in group 2 (36.97 ± 8.47% vs. 45.19 ± 5.22%, p = 0.004). Logistic regression and receiver operating characteristic analysis showed the preoperative DRF was the predictor for renal function improvement after pyeloplasty (p = 0.021) and had a significant predictive value (p = 0.004). Conclusion: Nearly half of the patients with high-grade UPJO had improved renal function at 1 year follow-up after laparoscopic pyeloplasty. Preoperative DRF was a predictor of renal function improvement, and postoperative functional recovery was superior in children with lower preoperative DRF.
ВПЛИВ ТЕРАПЕВТИЧНИХ ВПРАВ НА ПЕРЕБІГ РЕВМАТОЇДНОГО АРТРИТУ
Authors: Марʼяш В. В.
Published: March 2023

У статті проаналізовано вплив терапевтичних вправ на перебіг ревматоїдного артриту. Мета роботи полягала в розробці програми фізичної терапії для пацієнтів з ревматоїдним артритом та оцінці її ефективності за допомогою клінічного індексу активності захворювання (Clinical Disease Acti­vity Index – CDAI). На основі теоретичного і практичного аналізу обґрунтовано застосування  CDAI під час проведення лікування хворих на ревматоїдний артрит. При поєднанні стандартної терапії ревматоїдного артриту з апаратною фізіотерапією та індивідуальними терапевтичними вправами після лікування спостерігають кращий ефект відповідно до даних  CDAI порівняно з групою, в якій проводили стандартне лікування згідно з уніфікованим клінічним протоколом. Терапевтичні вправи є ефективними методами у лікуванні пацієнтів з ревматоїдним артритом, не мають побічних ефектів на відміну від медикаментозного лікування та зменшують активність захворювання.
ЗАГАЛЬНІ АСПЕКТИ ВАЖЛИВОСТІ РОЛІ ЕМОЦІЙНОГО ІНТЕЛЕКТУ В СЕСТРИНСЬКІЙ СПРАВІ
Authors: Дрогомирецька Н. Р.
Published: March 2023

У статті проаналізовано загальну важливість емоційного інтелекту у формуванні й становленні працівника сестринського персоналу.
ЗМІНИ ВМІСТУ МОЛЕКУЛ СЕРЕДНЬОЇ МАСИ У ЩУРІВ-САМИЦЬ З ПАТОЛОГІЄЮ ЯЄЧНИКІВ ТА КОРЕКЦІЯ ЇХ ПРЕПАРАТАМИ ІНОЗИТОЛУ
Authors: Терлецька Н. Ю. , Денефіль О. В.
Published: March 2023

Вступ. Проблема безпліддя є актуальною і на сьогодні. Основними причинами його розвитку є вік; стреси, сидячий спосіб життя, вплив солей важких металів. Препарати інозитолу покращують репродуктивну функцію жінки.

Мета дослідження – оцінити розвиток ендогенної інтоксикації у щурів-самиць з патологією яєчників та провести корекцію препаратами інозитолу.

Методи дослідження. Досліди виконано на 144 білих щурах-самицях лінії Вістар, яких поділили на 4 серії: 1-ша – контроль (щури віком 3,5–4 місяці); 2-га – тварини віком 7,5–8 місяців; 3-тя – щури, яким інтрагастрально 15 днів вводили розчин ацетату свинцю в дозі 0,05 мг/кг; 4-та – тварини, в яких викликали гіподинамічний стрес. У кожній серії було по 3 групи: А – контроль, Б – інозитол, В – FT 500 plus. Інозитол та FT 500 plus вводили інтрагастрально 15 днів з розрахунку 400 мг/кг інозитолу. В сироватці крові визначали вміст молекул середньої маси (МСМ) при λ 280, 260, 254 і 238 нм.

Результати й обговорення. У контролі найбільший вміст МСМ238 спостерігали в 3А групі. У 2А та 4А групах значення були меншими від контролю на 35,7 і 67,9 %. Вміст МСМ254 зріс у 2А та 3А групах, порівняно з 1А, у 2,4 і 3,0 рази. Рівень МСМ260 перевищував показник 1А групи тільки у 2-й с???? ? ?? 44,4 %. ????? ???ерії – на 44,4 %. Вміст МСМ280 був найменшим у серії контролю. Інозитол у щурів 1-ї серії спричинив зниження рівня МСМ238 і МСМ280, зростання – МСМ254 та МСМ260. FT 500 plus призвів до зменшення вмісту МСМ238, але збільшення МСМ254 і МСМ280. У 2-й серії інозитол сприяв зниженню рівня МСМ254 та МСМ280. FT 500 plus викликав зменшення вмісту всіх МСМ. У 3-й серії інозитол та FT 500 plus сприяли зниженню рівня МСМ238 і МСМ280, зростанню вмісту МСМ260. У 4-й серії інозитол спричинив зменшення вмісту МСМ280, але збільшення рівня МСМ254. FT 500 plus призвів до підвищення вмісту МСМ238, МСМ254 і МСМ280.

Висновки. Препарати інозитолу в дозі 400 мг/кг недоцільно використовувати в експерименті для здорових молодих щурів-самиць. У тварин віком 7,5–8 місяців оптимальним для зменшення ендогенної інтоксикації є FT 500 plus. У щурів, які зазнали впливу нанодоз ацетату свинцю, ефективність від застосування інозитолу та FT 500 plus однакова. У щурів, які тривалий час перебувають у гіподинамії і стресі, використання препаратів інозитолу не є ефективним.
Temas de pesquisa, fontes e métodos da demografia histórica do Brasil
Authors: Henry Louis
Published: March 2023

(1º parágrafo do artigo)

Em Demografia, como nas demais ciéncias humanas, a experimentaçäo é impossivel, ou seja, o demógrafo náo pode variar, de acordo com seus interesses, as condições nas quais desenvolveu-se uma população. Ele somente pode dispor do que a observação lhe fornece, o que afinal é uma colheita pobre e pouco variada, porque as condições são frequentemente semelhantes ou próximas, e porisso mesmo, elas apenas cobrem uma reduzida parte das condições possíveis. Os inconvenientes desta situação são agravados pela tendência da maioria dos demógrafos em se limitar à atualidade, por vezes apenas à atualidade de seu próprio país.
Preferential Hematopoietic Differentiation in Induced Pluripotent Stem Cells Derived From Human Umbilical Cord Arterial Endothelial Cells
Authors: Pei Haiyun , Li Huilin , Xu Lei , Zhang Bowen , Zhang Heng , Jia Yali , Liang Liqing , Xie Xiaoyan , Fan Zeng , Yang Zhou , Wang Xiaoling , Song Feiling , He Lijuan , Yue Wen , Pei Xuetao
Published: March 2023

Background:

The major obstacle for applications of human induced pluripotent stem cells (hiPSCs) is efficient and controlled lineage-specific differentiation. Hence, a deeper understanding of the initial populations of hiPSCs is required to instruct proficient lineage commitment.

Methods:

hiPSCs were generated from somatic cells by transduction of 4 human transcription factors (OCT4, SOX2, KLF4, and C-MYC) using Sendai virus vectors. Genome-wide DNA methylation analysis and transcriptional analysis were performed to evaluate the pluripotent capacity and somatic memory state of hiPSCs. Flow cytometric analysis and colony assays were performed to assess the hematopoietic differentiation capacity of hiPSCs.

Results:

Here, we reveal human umbilical arterial endothelial cell–derived induced pluripotent stem cells (HuA-iPSCs) exhibit indistinguishable pluripotency in comparison with human embryonic stem cells and hiPSCs derived from other tissues of origin (umbilical vein endothelial cells, cord blood, foreskin fibroblasts, and fetal skin fibroblasts). However, HuA-iPSCs retain a transcriptional memory typical of the parental human umbilical cord arterial endothelial cells, together with a strikingly similar DNA methylation signature to umbilical cord blood–derived induced pluripotent stem cells that distinguishes them from other human pluripotent stem cells. Ultimately, HuA-iPSCs are most efficient in targeted differentiation toward hematopoietic lineage among all human pluripotent stem cells based on the functional and quantitative evaluation of both flow cytometric analysis and colony assays. Application of the Rho-kinase activator significantly reduces the effects of preferential hematopoietic differentiation in HuA-iPSCs, reflected in CD34
+
cell percentage of day 7, hematopoietic/endothelial-associated gene expression, and even colony-forming unit numbers.

Conclusions:

Collectively, our data suggest that somatic cell memory may predispose HuA-iPSCs to differentiate more amenably into hematopoietic fate, bringing us closer to generating hematopoietic cell types in vitro from nonhematopoietic tissue for therapeutic applications.
PERCEPTION OF FACIAL SYMMETRY IN UPRIGHT AND INVERTED FACES
Authors: Luniakova Elizaveta G. , Kurenkova Alexandra I.
Published: March 2023

Background. X e uniqueness of human face perception mechanisms and their variability has become a subject for extensive investigation and wide discussion in the recent decades. While now the concept that human face is perceived as a whole is taken as a fact, the same cannot be said about the structure and methods to measure holistic processing. In the present study the factor of symmetry is investigated as one of the possible aspects of conW gural processing of facial perception. Objective. X e aim of the study was to apply the inversion method to the investigation of how distortion of facial conW guration perception impacts the rating of its symmetry/asymmetry Sample. 54 participants (24 female and 30 male) aged 18 to 68 (mean age 26) took part in the study. Method. An intra-individual experimental design was used. Participants rated asymmetry of normally oriented and inverted face-stimuli on a W ve-point scale. To set the symmetry level, leY eye and/or mouth regions were rotated around their W ducial points, there were three rotation angles for each feature region. Zero asymmetry faces were created by blending halves of normal and mirror images of the sample face-stimulus. X e mean asymmetry subjective ratings were submitted to repeated measures analysis of variance and paired samples t-test. Results. X e study revealed signiW cant diZ erences in the asymmetry ratings of upright and inverted faces: normal upright faces with rotated features were rated as more asymmetric compared to inverted. X us, we may conclude that symmetry perception is aZ ected by inversion. It was also revealed, that the eZ ect of the eye region and the lips region rotation were not equivalent: the higher the level rotation of the eye area was the more signiW cant the diZ erence between the rates of upright and inverted faces was, while rotation of the lips area did not result in higher diZ erence between the rates. Conclusion.X e observed face-inversion eZ ect in the perception of symmetry in facial stimuli suggests that (a)symmetry is a component of holistic (conW gurative) processing of human face perception. At the same time, the contributions of individual features to the overall facial conW guration may diZ er.
SUBJECTIVE ASPECT OF RESTING STATE: AN OVERVIEW OF RESEARCH METHODS
Authors: Bychkova Alesia S. , Krotkova Olga A. , Enikolopova Elena V.
Published: March 2023

Background. In recent years, the resting state of the subject in the absence of obvious external sensory stimuli and cognitive tasks has become the subject matter of extensive study. Interest in studying the subjective aspect of calm wakefulness has increased since the emergence of neuroimaging studies indicating the existence of a cerebral network that increases its activity in resting state. X ere is a variety of methodological approaches to assess the content of the stream of thoughts in calm wakefulness. X e issue of elaborating a universal tool to register the subjective aspect of the restful state remains relevant. Objective.X e study aims to analyze the existing methodological approaches to the research of the subjective part of the resting state. Methods. Review and analysis of existing research into the content of the stream of thoughts in calm wakefulness. Results. Studies of the free stream of consciousness in a state of calm wakefulness, such as questionnaires, structured interview, reports on the current state at the time of a random signal have been analysed in the current work. Conclusion. X e conducted literature review demonstrated the methodological diversity of assessment approaches to the subjective aspect of the restful state, and also showed the need to take into account various factors aY ecting the reliability of the results obtained. X e necessity of applying additional methods to solve speciJ c research problems as well as the possibility of developing a high-quality universal diagnostic tool to analyze the content of the stream of consciousness in rest are being discussed.
QUANTITATIVE METHODS IN THE HISTORICAL AND PSYCHOLOGICAL STUDY INTO THE CATEGORICAL STRUCTURE OF VALUES AND IMAGES IN DIFFERENT CULTURES
Authors: Danilova Anna G.
Published: March 2023

Background. X e growing interest in the historical development of social systems requires an assessment of the possibilities for a quantitative comparison of psychological characteristics in a person and society of diY erent eras. Objective.X e study aims to reveal the structure of social values and features of contemporary images according to verbal and visual texts of the cultures in the past.Methods. Behavior characteristics describing G. Hofstede’s basic cultural dimensions (Hofstede, 1980) were used to encode texts. Psychosemantic assessment of the works of art perception was carried out with the use of a scale based on the multifaceted Five Factor Model of personality by P. Costa, R. McCrae (FFM; NEO-PI-R questionnaire adapted by V.E. Orel et al.) and the scale of individual image perception in media communication by L.V. Matveeva et al. Sample. A) Ancient Greek and Roman texts of 7th c. BC — 4th c. AD, Old Russian texts of 11th–17th centuries, Byzantine texts of 5th–15th centuries and texts of medieval European culture according to the 17th c.— a total of 205 separate texts. B) Visual stimulus material on cultures: Ancient Greece (7th–1th c. BC); Ancient Rome (7th c. BC — 4th c. AD); Byzantium (5th–15th cc.); Russia (11–19 cc.); Europe (9th, 11th–17th cc.) was assessed by respondents of diY erent ages from 14 to 70 (N = 68). Results. Reliability analysis and confirmatory factor analysis generally supported the structure of the W ve-factor model of personality and the basic dimensions of culture by G. Hofstede on the material of historical texts and works of art. X e least stable dimensions are Hofstede’s Masculinity and Openness to Experience factors of the personality model. An exploratory factorial analysis of data on historical texts yielded a factor structure reZ ecting speciW c aspects of Hofstede’s dimensions. In general, the correlations between personality traits and basic cultural dimensions described by G. Hofstede and R. McCraе (Хофстеде, МакКрэй, 2010) are reproduced. X e diY erences mainly relate to the FFM factor “Extraversion”. X e features of social situations described in historical narratives that are not W xed by the characteristics of behavior that describe the basic dimensions of culture according to Hofstede are discussed. Conclusion. X e subdimensions of modern models of personality and cultural values make it possible to obtain a fairly adequate quantitative assessment of the cultures of the past.
An updated checklist of Araceae, Leguminosae and Myrtaceae of the department of Boyacá, Colombia, including keys to genera and new occurrence records
Authors: LUCAS EVE J. , HAIGH ANNA L. , CASTELLANOS CESAR , AGUILAR-CANO JOSÉ , BIGGS NICOLA , CASTELLANOS CAROLINA C. , FABRIANI FEDERICO , FRISBY SUSAN , GARCÍA LINA , KLITGÅRD BENTE B. , MORALES-PUENTES MARIA EUGENIA , PARRA-O. CARLOS , PEREZ-ESCOBAR OSCAR , ZULUAGA ALEJANDRO , LEWIS GWILYM P.
Published: March 2023

Baseline checklists for the Leguminosae (Fabaceae), Araceae and Myrtaceae from the Colombian department of Boyacá are available from the Catalogue of Plants and Lichens of Colombia. These lists were supplemented by thorough herbarium and literature searches by a collaborative group of local and international experts, and further enhanced by local field collections. The result is authoritative taxonomic checklists for the three families including data regarding habit, plant uses and species conservation risk assessments for a subset of species. The checklists have notably increased the number of species reported from Boyacá and provide reliable, taxonomically up-to-date inventories for those families. Checklists are based on specimens vouchered in local herbaria and revised specimen metadata is lodged in the Colombian biological information platform CEIBA. The initiative demonstrates how relatively low levels of funding allow taxonomic experts working in networks to rapidly improve the taxonomic understanding of angiosperm species diversity in megadiverse countries like Colombia.
A nomenclatural and taxonomic review of the Campanulaceae described in Vellozo’s Flora Fluminensis
Authors: ROLLIM ISIS DE MELLO , PERES COELHO GUILHERME , TERESINHA SFOGGIA MIOTTO SILVIA , RICARDO VIEIRA IGANCI JOÃO , TROVÓ MARCELO
Published: March 2023

Species of the Campanulaceae described by Frei José Mariano da Conceição Vellozo in his Flora Fluminensis are revised. All of them were placed by Vellozo in the genus Lobelia; however, three names have been placed in the synonymy with other genera by previous revisions: L. fluminensis (= Siphocampylus fluminensis), L. ignea (= S. corymbifer), and L. purpurea (= Centropogon cornutus). The present work indicates L. alpina as a synonym of L. camporum. Among the species described by Vellozo, only L. fistulosa is currently accepted as a valid name, while L. ensiformis remains doubtful, not corresponding clearly to any known species. Five lectotypes are designated to clarify application of Vellozo’s names. Photos of the known species in situ are provided.
Metabolite Study of Cecal Ligation and Puncture-Induced Sepsis Rats Based on Macro Metabolomics
Authors: Feng Qing-Long , Zhang Yi , Xu Chao-Qun , Xu Sai-Chan , Xiang Lei , Zhang Yu-Mei , Pan Xi-Ming
Published: March 2023

Sepsis is a syndrome of a systemic inflammatory response. This study is to anlyze metabolites changes in sepsis. A rat model of sepsis was established by cecal ligation and puncture surgery. Then blood, ileal tissue and feces samples of rats were collected. The pathological changes
of rat ileum and the levels of IL-1β, IL-6, HMGB-1, MCP-1, SOD and MDA were detected by HE staining and ELISA assay. FD-40 was detected to assess the integrity of the intestinal barrier. Fecal metabolites changes were analyzed by metabolomics based on UPLC-MS/MS system. Intestinal
injuries were obvious in rat model of sepsis, the levels of IL-1β, IL-6, HMGB-1, MCP-1, MDA and FD-40 increased, while the content of SOD in the CLP group was decreased. For metabolomics analysis, the results showed profiles and changes in the sepsis rat fecal metabolite. Moreover,
15 different potential biomarker metabolites, mainly including Carbohydrates and Amino Acids. This study found that the key differential metabolites in the sepsis rats are carbohydrates and organic acids.
Nomenclature in Palliative Surgery
Authors: Kopecky Kimberly E. , Strong Erin A. , Pellizzeri Katherine F.
Published: March 2023

Surgical palliative care, palliative care interventions, and palliative surgery all reference a blend of these 2 sub-specialty fields. Despite prior published definitions, use of these phrases both clinically and in the literature is varied and can lead to confusion and misunderstanding. Herein, we proposed the adoption of standardized nomenclature to guide the consistent use of these phrases.
Tympanoplasty in the Setting of Complex Middle Ear Pathology: A Systematic Review
Authors: Gutierrez Jorge A. , Cabrera Claudia I. , Stout Amber , Mowry Sarah E.
Published: March 2023

Objective:

To assess the prognostic factors for anatomic and hearing success after tympanoplasty in the setting of complex middle ear pathology.

Methods:

A systematic review was performed in January 2022. English-language articles describing outcome data for tympanoplasty repair variables including underlying pathology, perforation location, smoking status, graft technique, reconstruction material, anatomic success, and hearing success were extracted. Articles were included when tympanosclerosis, retraction pockets, adhesions, cholesteatoma, chronic suppurative otitis media, anterior perforations, and smoking were included. Underlying pathology, perforation location, smoking status, graft technique, reconstruction material, anatomic success, and hearing success were extracted. Any factors analyzed as potential indicators of success were sought out.

Results:

Data sources included PubMed, OVID, Cochrane, Web of Science, Scopus, and manual search of bibliographies. Ninety-three articles met final criteria, which accounted for 6685 patients. Fifty articles presented data on both anatomic and hearing outcomes, 32 articles presented data on anatomic outcomes only, and 11 articles presented data on hearing outcomes only. This systematic review found that adhesions and tympanosclerosis were prognostic factors for poorer hearing. Additionally, smoking and tympanosclerosis may be predictive of anatomic failure; however, the significance of this finding was mixed in included studies. This analysis is significantly limited by both the heterogeneity within the patients and the lack of controls.

Conclusion:

Adhesions and tympanosclerosis were prognostic factors for poorer hearing. Clearly documented methods and outcomes for the included pathologies could lead to more definitive conclusions regarding prognostic factors for success.

Level of Evidence:

3B
Effectiveness of Screening for Household Gun Ownership in an Urban Primary Care Clinic
Authors: Winterer Courtney M. , Cowden John D. , Williams Kristi , Gupta Rupal C. , Northup Ryan , Julian Joseph , Phillips George C. , Colvin Jeffrey D.
Published: March 2023

Gun-related suicide and homicide are leading causes of death among children. Little is known about the effectiveness of screening for gun ownership in primary care. We examined positive gun ownership screens over a 2.5-year period in a pediatric primary care clinic. The main outcome was a positive screen for gun ownership. The main predictors included insurance type, neighborhood median income, number of clinic visits, and other social needs. Of 19 163 patients, 474 (2.5%) screened positive for gun ownership. Patients with private insurance and from higher income neighborhoods had 2 to 3 times higher odds of a positive screen. Patients with more visits and with food insecurity had approximately 2 to 4 times the odds of a positive screen for household gun ownership. In conclusion, the rate of positive gun ownership screens was very low and far below known gun ownership rates. Improved screening methods could better identify opportunities for gun safety advocacy.
Un’altra casa I. La proposta culturale per l’emigrazione italoamericana di Divagando (1943–63)
Authors: Marazzi Martino
Published: March 2023

In its twenty years of publication, the Italian-language, New York-based weekly magazine Divagando (1943–1963) showcased – in its very diversified columns, in its eye-catching covers and layout, in its advertising campaigns – the lure and snare of modern times and the characteristic energy of the post-WWII period. At the same time, the keen attention to a wide public of immigrant background translated into a distinct Italian accent, which proved particularly noteworthy in the offer of bicultural literary products – from Manzoni to Faulkner – and of fiction aimed at a readership of “new” Italian ethnic women.
Religious coping, care burden and psychological distress among informal caregivers of COVID-19 patients: Results of a cross-sectional survey in Pakistan
Authors: Rashid Muhammad Abo ul Hassan , Muneeb Syed Ali , Manzoor Malik Maliha , Fischer Florian
Published: March 2023

Background:

There is a complex relationship between health and religiosity. People may use religion to cope with difficulties and uncertainties in their life – such as induced by the COVID-19 pandemic.

Aims:

The purpose of this study is to investigate the relationship between religious coping, care burden and psychological distress among caregivers during COVID-19 in Pakistan.

Method:

We conducted a cross-sectional survey in Pakistan. We used the Religious Coping Scale (RCOPE), Care Burden Scale (CB), and Depression, Anxiety and Stress Scale (DASS-21) to measure psychological stress from 303 caregivers. Data were analyzed using a hierarchical linear regression model for each of the three outcome variables, which are depression, anxiety, and stress. This analysis allows to investigate whether adding variables significantly improves a model’s ability to predict the criterion variable.

Results:

The findings reveal that emotional care burden, physical care burden, negative religious coping, and social care burden explain a significant amount of the variance of three components of psychological distress among caregivers.

Conclusions:

Health experts, psychologists, and policymakers can make better strategies to combat pandemics like COVID-19 by incorporating religious coping methods.
Artificial intelligence's interpretation of the neuroanatomical aspect of Peter Paul Rubens's copy of “The Battle of Anghiari” by Leonardo da Vinci
Authors: Keshelava Grigol
Published: March 2023

We tested to see how Ruben’s copy of “The Battle of Anghiari” by Leonardo da Vinci would be interpreted by AI in a neuroanatomical aspect. We used WOMBO Dream, an artificial intelligence (AI)-based algorithm that creates images based on words and figures. The keyword we provided for the algorithm was “brain” and the reference image was Ruben’s drawing. AI interpreted the whole drawing as a representation of the brain. The image generated by the algorithm was similar to our interpretation of the same painting.