bluuebunny/crossref_metadata_2025 huggingface dataset:
Probabilistic end-to-end irradiance forecasting through pre-trained deep learning models using all-sky-images
Authors: Chaaraoui Samer , Houben Sebastian , Meilinger Stefanie
Published: January 2024

Abstract. This work proposes a novel approach for probabilistic end-to-end all-sky imager-based nowcasting with horizons of up to 30 min using an ImageNet pre-trained deep neural network. The method involves a two-stage approach. First, a backbone model is trained to estimate the irradiance from all-sky imager (ASI) images. The model is then extended and retrained on image and parameter sequences for forecasting. An open access data set is used for training and evaluation. We investigated the impact of simultaneously considering global horizontal (GHI), direct normal (DNI), and diffuse horizontal irradiance (DHI) on training time and forecast performance as well as the effect of adding parameters describing the irradiance variability proposed in the literature. The backbone model estimates current GHI with an RMSE and MAE of 58.06 and 29.33 W m−2, respectively. When extended for forecasting, the model achieves an overall positive skill score reaching 18.6 % compared to a smart persistence forecast. Minor modifications to the deterministic backbone and forecasting models enables the architecture to output an asymmetrical probability distribution and reduces training time while leading to similar errors for the backbone models. Investigating the impact of variability parameters shows that they reduce training time but have no significant impact on the GHI forecasting performance for both deterministic and probabilistic forecasting while simultaneously forecasting GHI, DNI, and DHI reduces the forecast performance.
Reviews and syntheses: expanding the global coverage of gross primary production and net community production measurements using Biogeochemical-Argo floats
Authors: Izett Robert W. , Fennel Katja , Stoer Adam C. , Nicholson David P.
Published: January 2024

Abstract. This paper provides an overview and demonstration of emerging float-based methods for quantifying gross primary production (GPP) and net community production (NCP) using Biogeochemical-Argo (BGC-Argo) float data. Recent publications have described GPP methods that are based on the detection of diurnal oscillations in upper-ocean oxygen or particulate organic carbon concentrations using single profilers or a composite of BGC-Argo floats. NCP methods rely on budget calculations to partition observed tracer variations into physical or biological processes occurring over timescales greater than 1 d. Presently, multi-year NCP time series are feasible at near-weekly resolution, using consecutive or simultaneous float deployments at local scales. Results, however, are sensitive to the choice of tracer used in the budget calculations and uncertainties in the budget parameterizations employed across different NCP approaches. Decadal, basin-wide GPP calculations are currently achievable using data compiled from the entire BGC-Argo array, but finer spatial and temporal resolution requires more float deployments to construct diurnal tracer curves. A projected, global BGC-Argo array of 1000 floats should be sufficient to attain annual GPP estimates at 10∘ latitudinal resolution if floats profile at off-integer intervals (e.g., 5.2 or 10.2 d). Addressing the current limitations of float-based methods should enable enhanced spatial and temporal coverage of marine GPP and NCP measurements, facilitating global-scale determinations of the carbon export potential, training of satellite primary production algorithms, and evaluations of biogeochemical numerical models. This paper aims to facilitate broader uptake of float GPP and NCP methods, as singular or combined tools, by the oceanographic community and to promote their continued development.
Could old tide gauges help estimate past atmospheric variability?
Authors: Platzer Paul , Tandeo Pierre , Ailliot Pierre , Chapron Bertrand
Published: January 2024

Abstract. The storm surge is the non-tidal component of coastal sea-level. It responds to the atmosphere both through the direct effect of atmospheric pressure on the sea-surface, and through Ekman transport induced by wind-stress. Tide gauges have been used to measure the sea-level in coastal cities for centuries, with many records dating back to the 19th-century or even further, at times when direct pressure observations were scarce. Therefore, these old tide gauge records may be used as indirect observations of sub-seasonal atmospheric variability, complementary to other sensors such as barometers. To investigate this claim, the present work relies on tide gauge records of Brest and Saint-Nazaire, two portal cities in western France, and on the members of NOAA's 20th-century reanalysis (20CRv3) which only assimilates surface pressure observations and uses numerical weather prediction model. Using simple statistical relationships between storm surges and pressure maps, we show that the tide gauge records reveal part of the 19th-century atmospheric variability that was uncaught by the pressure-observations-based reanalysis. In particular, weighing the 80 reanalysis members based on tide gauge observations indicates that a large number of members are very unlikely, which induces corrections of several tens of Hectopascals in the Bay of Biscay. These findings support the use of early tide gauge records in sensor-scarce areas, both to validate old atmospheric reanalyses and to better probe old atmospheric sub-seasonal variability.
Inovasi Pelatihan Guru Berbasis Data: Optimalisasi Program melalui Keterlibatan Forum Guru dan Yayasan
Authors: Al Amin Fuat , Pratama Panji
Published: January 2024

Penelitian ini bertujuan untuk mengkaji asumsi bahwa program pelatihan guru tidak perlu berdasarkan pada pengambilan keputusan yang berdasarkan data. Penelitian ini mendiskusikan bahwa pendekatan tersebut mengabaikan faktor-faktor kontekstual dan peran penting guru dalam pengembangan profesional mereka. Metode penelitian yang digunakan adalah kualitatif, dengan melakukan studi kasus ganda pada tiga sekolah dasar Islam yang menerapkan program pelatihan guru berbasis data. Berdasarkan penelitian ditemukan bahwa guru-guru agama menghadapi berbagai tantangan dalam beradaptasi dengan era digital, dalam hal ini forum guru memiliki peran yang signifikan dalam menentukan konten serta format program pelatihan dan manajemen yayasan memiliki pengaruh penting terhadap kualitas serta keberlanjutan program pelatihan. Berdasarkan temuan, dapat disimpulkan bahwa program pelatihan guru harus lebih responsif terhadap kebutuhan dan preferensi para guru.
O papel fundamental dos tecnólogos e técnicos em Radiologia nas investigações Forenses
Authors: Vergara Clayton Sidney de Almeida
Published: January 2024

A Radiologia Forense é uma área da medicina legal que utiliza técnicas de imagem para investigar crimes, ajuda a identificar lesões, analisar restos mortais e até reconstruir acontecimentos, é uma combinação crucial entre a medicina e a investigação criminal. A questão motivadora do estudo foi: “Qual a justificativa da carência dos técnicos e tecnólogos em radiologia atuando nos setores de imagens forense?” a partir dela, surge o objetivo do presente artigo que é tentar estudar o motivo da carência de técnicos e tecnólogos em radiologia nos setores de imagens forenses. Para atingir o objetivo deste trabalho, foi realizado um estudo exploratório, qualitativo de revisão narrativa da literatura. Os profissionais de técnicas radiológicas em investigação forense são responsáveis pela utilização de equipamentos de raios X convencionais, tomografia computadorizada e ressonância magnética, para auxiliar na análise de evidências e na identificação de lesões. Eles desempenham um papel fundamental na obtenção de informações valiosas para a resolução de crimes. É uma área muito interessante que exige competências técnicas e conhecimentos especializados onde infelizmente há uma carência destes profissionais em instituições forenses.
دور استراتيجية المحيط الأزرق في تعزيز كفاءة برنامج ريادة الأعمال بالغرفة التجارية الصناعية بجدة ودورها في عملية التبادل المعرفي (نموذج مقترح)
Authors:   باحث دكتوراه في إدارة المعرفة، قسم علم المعلومات، كلية الآداب والعلوم الإنسانية، جامعة الملك عبد العزيز، المملكة العربية السعودية, آل عطيف محمد
Published: January 2024

هدفت الدراسة إلى تحليل دور اتحاد الغرف في تعزيز ريادة الأعمال في المملكة العربية السعودية، من خلال فهم الاستراتيجيات والمبادرات التي تم اعتمادها من قبل الاتحاد لتعزيز بيئة ريادة الأعمال، وتحديد التحديات التي يمكن أن تواجه غرفة جدة في تنفيذ استراتيجية المحيط الأزرق في مجال ريادة الأعمال، وذلك باستكشاف الفرص الغير مستغلة التي يمكن تحقيقها من خلال تنفيذ استراتيجية المحيط الأزرق، وذلك تبعاً لأهميته الكبيرة بتوفير فهم أعمق حول كيفية تطبيق نظريات إدارية محددة، مثل استراتيجية المحيط الأزرق، في سياق الريادة والأعمال، مما يساهم في تطوير النظريات الإدارية، واستكشاف إمكانيات توظيف استراتيجية المحيط الأزرق في تعزيز فعالية برامج ريادة الأعمال يمكن أن يقدم رؤى جديدة تثري الأدب البحثي في مجال الريادة والجهات الداعمة. حيث توصلت الدراسة إلى عدة نتائج عن طريق استخدام المنهج الوصفي، والتحليلي، وأبرزها أن استراتيجية المحيط الأزرق تلعب دوراً رئيسياً في تحسين كفاءة المبادرات الريادية من خلال دعم عملية تبادل المعرفة وتعزيز التواصل وتطوير المهارات اللازمة، وأن استراتيجية المحيط الأزرق تعتبر عاملاً مهماً في تحسين كفاءة خطط ريادة الأعمال من خلال تحفيز التفكير الإبداعي واستكشاف فرص جديدة في السوق، وأهم ما أوصت الدراسة به أنه يجب توسيع فهم فريق ريادة الأعمال حول مفهوم المحيط الأزرق وكيف يمكن تطبيقه في سياق البرنامج، ووجوب التشجيع على التعاون بين القطاعات الحكومية والخاصة والهيئات الريادية من خلال إقامة فعاليات وورش عمل مشتركة، كما أوصت بالبحث بتعزيز استخدام التكنولوجيا في تبادل المعرفة وتعزيز التواصل بين أفراد فريق ريادة الأعمال، من خلال تقديم تدريبات حول استخدام تقنيات متقدمة لتحسين فعالية تبادل المعرفة.
أثر التدريس بأسلوب التكامل المعرفي لمقرر القرآن الكريم في تنمية الوعي القيمي لدى الطلاب من وجهة نظر المعلمين
Authors:   باحث دكتوراه، قسم القيادة والسياسات التربوية، جامعة الملك خالد، المملكة العربية السعودية, جعفري عبدالله , الحارثي عبدالرحمن ,   أستاذ أصول التربية المشارك، كلية التربية، جامعة الملك خالد، المملكة العربية السعودية
Published: January 2024

هدفت هذه الدراسة إلى تقصي أثر التدريس بأسلوب التكامل المعرفي لمقرر القرآن الكريم في تنمية الوعي القيمي لدى الطلبة من الناحية الدينية والاجتماعية والتعليمية، من وجهة نظر المعلمين، تكمن أهمية الدراسة في توضيح أثر التكامل المعرفي على الوعي القيمي لدى الطلبة، وفي مساعدة المعلمين على تنمية الوعي بالقيم المستنبطة من القرآن الكريم لدى طلابهم، وتكون مجتمع الدراسة من جميع معلمي ومعلمات القرآن الكريم بمحافظة صبيا للعام 1445/2023، واقتصرت العينة على مجموعة من معلمي ومعلمات مكتب تعليم الداير بمحافظة صبيا وعددهم (30)، ووظف فيها المنهج الوصفي، واستخدم الباحث الاستبانة كأداة للدراسة، وأظهرت الدراسة: وجود تأثير للتدريس بأسلوب التكامل المعرفي لمقرر القرآن الكريم في تنمية الوعي بالقيم التعليمية لدى الطلبة من وجهة نظر المعلمين، ومن خلال الإجابة على التساؤلات الفرعية نحصل على الإجابة على السؤال الثاني وهو عدم وجود تأثير للتدريس بأسلوب التكامل المعرفي لمقرر القرآن الكريم في تنمية الوعي القيمي لدى الطلبة تعزى للمرحلة التعليمية، وفي ضوء ذلك أوصت الدراسة بضرورة تبني أسلوب التكامل المعرفي في تدريس مقرر القرآن الكريم لتنمية الوعي القيمي لدى طلبة التعليم العام كما أشارت إلى فاعلية استخدام أسلوب التكامل المعرفي لمقرر القرآن الكريم في تنمية الوعي القيمي لدى الطلبة، وضرورة الاهتمام بعقد دورات للمعلمين أثناء الخدمة لتدريبهم على استخدام أسلوب التكامل المعرفي، وإعداد دليل تطبيقي للمعلمين حول كيفية إعداد الدروس وتنفيذها باستخدام أسلوب التكامل المعرفي، ومن أبرز المقترحات التي خرجت بها: إجراء دراسات مشابهة للدراسة في مناطق تعليمية أخرى ومقارنة نتائجها بنتائج الدراسة الحالية، وإجراء دراسات تتناول أثر استخدام التكامل المعرفي في المقررات الدراسية المختلفة لتنمية الوعي القيمي.
A Scoping Review on Energy Drink Consumption Among Adolescents and Young Adults
Authors: Andrade Filipe , Thalheimer Gabriel , Vásquez Hidalgo Santiago , De Almeida Rosa Maria
Published: January 2024

This scoping review aimed to identify empirical studies that have explored the use of energy drink consumption among adolescents and young adults. Method: A scoping review search was conducted in the following five databases: PubMed, Embase, Lilacs, Scopus, and Psycnet. Some inclusion criteria, such as being published in the last 10 years, and exclusion criteria, such as article type, animal-model usage, and age, were used to select the studies, and 11 were analyzed independently. Results: The results showed that adolescents use energy drinks for many factors, such as connection with peers and family, propaganda, and taste. Some studies have been developed in Australia and the United States of America, and some have explored other variables associated with energy drinks and alcohol use. Conclusion: It is essential to understand how energy drink consumption and behaviors are related to health or risky behavior and its associations with other drugs. More research is needed to explore the long-term health impacts of energy drink consumption during the critical developmental periods of childhood and adolescence, as well as its association with alcohol and other substances. The findings underline the importance of stringent regulations, public health policies, and educational initiatives to mitigate the risks associated with energy drink consumption among adolescents. Future research is essential to understand the long-term implications and develop effective preventive strategies to safeguard adolescent health and well-being.
Physical exercise and chicken egg white supplementation increase muscle mass of stable COPD patients
Authors: Amin Mona N. , Tarigan Amira P. , Pradana Andika , Ashar Taufik , Osareniro Osakue E.
Published: January 2024

Patients with chronic obstructive pulmonary disease (COPD) commonly exhibit muscle atrophy and dysfunction due to a reduction in muscle mass; and protein supplements such as chicken egg whites have been reported to improve muscle mass. The aim of this study was to evaluate the impact of physical exercise and egg white supplementation on the muscle mass of COPD patients. An experimental study was conducted among stable COPD patients at Universitas Sumatra Utara Hospital Medan, Indonesia, between August and October 2022. The patients were divided into two groups, control and interventional groups, with each patient subjected to a pre- and post-muscle mass assessment. All the patients performed respiratory endurance and upper extremity muscle strength training three times/week for a total of 12 weeks. In addition, the patients in the intervention group were also given egg white supplementation (10 eggs/day) during the period of intervention in addition to the physical training. The Wilcoxon and Mann-Whitney tests were performed to identify the significance of the difference between pre- and post-intervention and between the control and intervention groups, respectively. A total of 38 COPD patients were included in the study, 19 from each group. Our data suggested no significant difference in muscle mass of the patients in the control group before and after 12 weeks of physical exercise (pre-intervention 27.37±4.54% and post-intervention 27.68±4.5% with p=0.174). However, there was a significant muscle mass increment of patients in the intervention group upon 12 weeks of physical training and egg white supplementation (pre-intervention 27.18±4.15%, post-intervention 29.95±3.76%, p<0.001). A significant difference in muscle mass was observed between patients in the control and the intervention groups (p=0.046) after the intervention. The study highlights that physical exercise in combination with egg white supplementation may serve as potential and effective non-pharmacological treatment for muscle mass restoration in COPD patients as compared to physical exercise alone.
GEOELECTRIC SIGNATURES FROM A LEACHATE PLUME MAPPED FROM A BASEMENT COMPLEX TERRAIN IN AKURE, NIGERIA
Authors: Ojo B. C. , Osotuyi A. G. , Olaiya B. T. , Salako A. O. , John S. J. , Omoniyi A. R.
Published: January 2024

In this study, we investigated the implications of a leachate plume within an aquifer system, unravelling the intricate dynamics that govern contaminant transport and dispersion. An integrated approach of geophysical investigations is used to establish the impact of an open-waste disposal site around Aromed, in a part of Akure, in the Precambrian Basement Complex of Southwestern Nigeria. Investigations using eight (8) Vertical Electrical Sounding (VES) and Double-Dipole Resistivity Tomography (ERT) along two (2) traverses were conducted. The geoelectric interpretation and the inverted two-dimensional electrical resistivity tomography (ERT) images provided insights into the underlying geological composition, identifying three distinct units: the topsoil, the weathered column, and the fractured Basement/fresh Basement bedrock. The geoelectric tomography structures in the 2-D interpretation reveal that the dumpsite area exhibits low apparent resistivity estimated to be between 12 to 71 ohm-m in both the topsoil and the weathered column aquiferous zone. These values closely agree with results from the geoelectric sections, which range between 11 - 68 ohm-m, respectively. The relatively low apparent resistivity results are suggestive to be due to the presence of leachate’s chemical composition from the open waste disposal sites, which are suspected to be generated from the dissolution of ions of iron and other conductive minerals producing the leachate plume. The probable leachate depth of migration as revealed by the 2-D tomography structures varies from about <1 – > 14 m beneath the dumpsites. The leachate migration, which is structurally controlled, has a southward flow, majorly in the orientation with the observed structures. The subsurface depression-relief is also attributed to influence the direction of leachate flow. In conclusion, it is suggested that groundwater in the aquiferous zones in the vicinity of the dumpsites have entered a significant pollution level; hence water in the aquifer is not safe for consumption.
The Influence of Capital Structure on Corporate Effective Tax Rates of Listed Firms in Tanzania
Authors: R.P. Mwandu , H. Msofe , T. Mwiru , P. Marwa
Published: January 2024

This study examines the relationship between capital structure and corporate effective tax rates using data from 25 randomly selected listed firms on the Dar es Salaam Stock Exchange over a ten-year span (2013–2022). We employed a random fixed effect panel regression model while controlling for firm-specific variables such as size, profitability, age, and growth. The study reveals a significant and negative relationship between capital structure and effective tax rates, implying that firms utilising higher debt financing tend to experience lower effective tax rates. Additionally, firm size and profitability exhibit a significant relationship with capital structure. These findings hold significant implications for Tanzanian businesses, suggesting that they may enhance tax efficiency through strategic capital structure decisions. For policymakers, the results provide empirical insights on potential tax policy reforms, potentially fostering a more favourable business environment in Tanzania. This research contributes empirical evidence on the financial and tax dynamics of listed firms in Tanzania.
Artificial Intelligence in Pharmacy
Authors: Kulkarni R. R. , Pawar P. S.
Published: January 2024

Artificial intelligence research tried and removed many of the different approaches since its founding, including simulating the brain, modeling human problem solving, learning, formal logic, large databases of knowledge and imitating animal behavior. Artificial intelligence in pharmaceutical industry shows no sign of slowing down. According to recent research, about 50% of global healthcare companies plan to implement artificial intelligence strategies broadly adopt the technology by 2025.
МЕКТЕП ОКУУЧУЛАРЫНДА МУЗЫКАЛЫК КАБЫЛ АЛУУНУ ӨНҮКТҮРҮҮ
Authors: Мурзакматов Аманбек , Абдираим уулу Куштарбек
Published: January 2024

Бул макалада музыка сабагынын жүрүшүндө мектеп окуучуларынын ар кыл класстарынын музыкалык кабыл алуусун калыптандыруу; окуучулардын музыкалык кабылдоосун өнүктүрүү ыкмалары көрсөтүлөт.
Exosomes Derived from Metastatic Colon Cancer Cells Induced Oncogenic Transformation and Migratory Potential of Immortalized Human Cells
Authors: Kesavan Yasodha , Sahabudeen Sheik Mohideen , Ramalingam Satish
Published: January 2024

Tiny vesicles, synthesized from cell membranes through endocytosis, form multivesicular bodies (MVBs). These MVBs can either undergo lysosomal degradation or be released to the extracellular environment. The vesicle that ranges in size from 30-300 nm that were positive for markers such as CD63 or CD9 are known as exosomes.  Exosomes are shown to contain various biological macromolecules such as DNA, RNA, miRNA, proteins, and lipids. Releasing exosomes from cells to the extracellular environment is an important strategy to transfer information between the cells. Exosomes from primary colon cancer cells have been shown to induce the oncogenic transformation of normal cells. In this study, we have demonstrated that treating normal cells (HEK) with exosomes derived from the metastatic colon cancer cell line (SW620) increases cell proliferation, allowing the normal cells to grow anchored independently, suggesting the oncogenic transformation of normal cells. In addition, there was an increase in migration and invasion properties of HEK cells exposed to exosomes from SW620 cells. Our results suggest that following the treatment with metastatic colon cancer cell-derived exosomes, the HEK cells underwent an oncogenic transformation and Epithelial-Mesenchymal Transition (EMT) that will allow the cancerous cells to metastasize.
The The Classification and Segmentation of Pneumonia using Deep Learning Algorithms: A Comparative Study
Authors: Mishra Vishnu Kumar , Mishra Megha , Sheetlani Jitendra , Kumar Anoop , Pachouri Priya , Nagapraveena Thirunagari , Puttamallaiah Amulya , Sravya Mandala Naga , Parijatha Kimidi
Published: January 2024

The paper uses convolutional neural networks (CNNs) to analyze radiography pictures and discriminate between areas afflicted by pneumonia and normal lung tissue.  A sizable dataset of annotated chest X-rays is used to train the deep learning model, which enables it to pick up on complex patterns and characteristics linked to pneumonia. Pneumonia is a significant respiratory disease that affects a large number of individuals worldwide. Timely and accurate diagnosis of pneumonia plays a crucial role in effective treatment and management of the disease. We evaluate the performance of several up-to-date convolution neural network (CNN) architectures, namely ResNet-50, VGG-16, and DenseNet-121, then compare their results with traditional machine learning classifiers.  Recent advancements in deep learning methods have shown accurate results in the investigation and diagnosis of medical image data, including the detection of pneumonia. This paper examines different deep-learning methods for categorizing pneumonia from lung X-ray imagery. Our results show that deep learning techniques performed better than conventional machine learning techniques in classifying pneumonia, with an estimated accuracy of 95% across all of the examined CNN models. These results demonstrate the potential of deep learning algorithms to significantly improve the accuracy and effectiveness of pneumonia diagnosis, supporting physicians in making knowledgeable decisions about patient care.
Analyzing the Performance of TAS/MRC with Decode-and-Forward Relaying for Multihop Transmission over Fisher-Snedecor F Fading Channels
Authors: Saikia Hubha , Mudoi Rajkishur
Published: January 2024

This study comprehensively assesses a decode-and-forward relaying system that employs Transmit Antenna Selection/Maximal Ratio Combining (TAS/MRC) for multi-hop communication across Fisher-Snedecor F fading channels. The study primarily focuses on the average symbol error rate (ASER) and outage probability (OP) while using cross QAM (XQAM) and rectangular quadrature amplitude modulation (RQAM). The proposed MIMO system effectively decreases the hardware complexity and cost of large antennas by implementing Transmit Antenna Selection (TAS) at the source and relay nodes and Maximum Ratio Combining (MRC) diversity at the destination and relays. Analytical formulations for OP (outage probability) and ASER (average symbol error rate) are derived using PDF (Probability Density Function)-based methods. Monte-Carlo simulations further validate these formulas. The investigation indicates that system performance is improved under conditions of lighter shadowing compared to moderate and extreme shadowing settings. Additionally, increasing the hop count amplifies the observed performance. Moreover, when the fading parameter increases, both the OP and ASER decrease. This study comprehensively examines the impact of many parameters, including m, p, L, R, and o, on the behaviour of the system under Fisher-Snedecor F fading. Based on the findings, the combination of shadowing and multipath fading significantly affects the system's performance, with both m and p significantly influencing this. When examining the Signal-to-Noise Ratio (SNR), a comparison between RQAM and XQAM demonstrates that XQAM is superior. The research uncovers crucial information for planning and executing the TAS/MRC-based MIMO multi-hop communication system. This technology possesses the capability to enhance the effectiveness of similar communication systems, as seen by the encouraging advancements in performance, especially in scenarios including signal attenuation.
Formulation and Drug Release Study of Rivaroxaban Oral Disintegrating Tablets Using Various Super-Disintegrants
Authors: Siddheshwar Suhas Shivaji , Ghorpade Asmita Bhausaheb , Mankar Someshwar Dattatraya , Dighe Santosh Bhausaheb
Published: January 2024

This study aims to improve Rivaroxaban's solubility, dissolution, and bioavailability. Orally disintegrating tablets (ODTs) made with super-disintegrants like crospovidone, sodium starch glycolate, and cross-carmellose sodium will do this. Tablet preparation used direct compression and formulation optimization with design expert software. After a thorough factorial design and evaluation of pre- and post-compression parameters, the F3 batch, which contained Rivaroxaban (7.97%), Crospovidone (3.59%), Croscarmellose sodium (5.18%), Sodium Starch Glycolate (5.18%), Lactose Anhydrous (31.08%), Mannitol (15.94%), MCC (27.89%), SSF (1.59%), and Talc (1.59%), was the best. The enhanced tablet formulation (F3) showed positive qualities, including 3.3 kg/cm² hardness, 23 seconds disintegration time, and 99% drug release after 30 minutes. The innovative Rivaroxaban orally disintegrating tablet (ODT) method disintegrated and dissolved faster than market forms. Rivaroxaban's physical and chemical properties were assessed before formulation. The medication was colorless, scentless, crystalline, and melted at 227°C-229°C, as described in published research. The pharmaceutical was found to be a BCS Class II drug with low water solubility and high solubility in acetate buffer pH 4.5 and 0.1 N Hydrochloric acid. Fourier-transform infrared spectroscopy (FTIR) confirmed no drug-polymer-excipient interactions. Every batch of tablets exhibited uniform thickness (3.5 mm to 3.8 mm) and diameter (10.31 mm to 10.36 mm), indicating good compression without adhering to shaping tools. All samples had a 3-5 kg cm-² hardness, indicating strong mechanical properties. The Roche friability method showed that all batches had good abrasion resistance, ranging from 0.1% to 0.5%. Variations in croscarmellose sodium and crospovidone on tablet disintegration time and hardness were examined using design expert software. The ANOVA showed important factors affecting these attributes. Data-driven polynomial equations predict tablet disintegration time and hardness. These models reveal formulation parameters that affect tablet performance. Thus, the improved F3 batch of rivaroxaban orally disintegrating tablets (ODTs) improves solubility, dissolving, and bioavailability. This may improve treatment outcomes.
Integrating Symbolic Simulation of C/C++ into a Comprehensive EDA Verification Environment
Authors: Melham Tom , Tiemeyer Andreas , Kröning Daniel , O'Leary John
Published: January 2024

Formal verification of chip designs - once thought to be an impractical dream - has matured through many years of technological innovation, investment, and experience into a mainstream verification tool used across the semiconductor design industry. Mature and highly capable tools, with rich debugging environments, are available from the EDA vendors - and the technology continues to advance. This talk will tell the story of how a software verification tool for C programs - the CMBC bounded model checker developed by Daniel Kroening - was leveraged to integrate C/C++ symbolic simulation into a commercial formal verification environment. The aim of this project was to move beyond an academic prototype and enable equivalence checking of digital circuit models against real-world C/C++ reference model code – with full access to the proof engines, verification control, and debugging tools of a leading commercial verification environment.
From Top-down Microarchitecture Analysis to Structured Performance Optimizations
Authors: Yasin Ahmad
Published: January 2024

This session re-caps on the Top-down µarch Analysis (TMA) method - that is widely adopted in performance profiling tools, Microarchitecture challenges faced in out-of-order cores, and the abstraction that helped the method to be universally supported across CPU vendors (Intel as well as AMD ARM).

Then, we show how the primary TMA metrics of Frontend Bound, Bad Speculation, Core Bound, Memory Bound and Retiring can be used to classify and direct exploitation of popular software optimizations.

The session closes with a use-case that got deployed in code generation of modern compilers. The use-case demonstrates how to mitigate Instruction Fetch Bandwidth issue through tuning of loop unrolling to speedup tight loops in recent wide-issue out-of-order cores.
Pengaruh Profitabilitas, Solvabilitas, Likuiditas Dan Ukuran Perusahaan Terhadap Financial Distress Pada Emiten Sebelum Dan Selama Terdampak Covid-19 Di Indonesia
Authors: Zuhri Arifin , Inayati Titik , Suryanto Adi
Published: January 2024

COVID-19 adalah issue kesehatan global yang terjadi dihampir semua Negara di dunia, termasuk di Indonesia. Kasus pertama COVID-19 di Indonesia terjadi pada awal Maret 2020 di Jakarta dan sejak saat itu Negara memberlakukan berbagai kebijakan untuk menyelamatkan warganya, diantaranya pembatasan pergerakan baik orang maupun barang. Berbagai pembatasan yang berlangsung menyebabkan penurunan kegiatan masyarakat dan juga kegiatan produksi dan distribusi bagi pelaku usaha, yang berpotensi menyebabkan kerugian dan tekanan keuangan (financial distress). Dari laporan penelitian dan catatan yang terkumpul baik dari buku, pemberitaan media maupun pre survey, ditemukan cukup banyak perusahaan yang terdampak pandemi COVID-19 berupa pembukuan minus pada perusahaannya pada tahun buku 2020. Beberapa rasio keuangan yang dapat digunakan untuk memprediksi terjadinya financial distress adalah provitabillitas, solvabilitas, liquiditas dan ukuran perusahaan. Jenis penelitian adalah penelitian kuantitatif dan bertujuan untuk menguji dan menganalisis pengaruh provitabilitas, solvabilitas, liquiditas dan ukuran perusahaan terhadap financial distress, dengan hipotesis awal diduga provitabilitas (X1), solvabilitas(X2), liquiditas (X3), dan ukuran perusahaan (X4) berpengaruh terhadap financial distress pada emiten sebelum dan selama terdampak COVID-19 di Indonesia (Y), dan mengaitkannya dengan agency theory . Metode sampling yang digunakan adalah purposive sampling dan didapat 185 Emiten yang diteliti. Metode penelitian yang digunakan yaitu multiple linear regression, sedangkan teknik analisa data dilakukan menggunakan analisis statistik deskriptif dan analisis statistik inferensial. Data penelitian yang diperoleh pada penelitian ini dianalisis lebih lanjut dengan menggunakan aplikasi IBM SPSS dan ditemukan formula regresi terbentuk yaitu : Y (FD) = 6,340 - 0,274 X1 (ROE) + 0,222 X2 (DER) - 0,506 X3 (CR) – 0,363 X4 (UP). Dengan kesimpulan profitabilitas, solvabilitas, likuiditas dan ukuran perusahaan berpengaruh berpengaruh signifikan terhadap financial distress pada emiten sebelum dan selama terdampak COVID-19 di Indonesia.
Estado nutricional y hábitos alimentarios post confinamiento por COVID-19 en adultos mayores de la parroquia Imantag, Cotacachi, 2022
Authors: Escobar Jurado María Bethzabe , Gómez Gordillo Alejandra Maribel
Published: January 2024

Durante el confinamiento por COVID-19 se observaron cambios significativos en los hábitos alimentarios, caracterizados por un patrón alimentario no saludable, mayor ingesta de productos ultra procesados y de baja calidad nutricional, desencadenando a un mayor riesgo de desnutrición. El objetivo del presente estudio fue relacionar el estado nutricional post confinamiento por COVID-19 y hábitos alimentarios en adultos mayores de la parroquia Imantag. La presente es de carácter descriptivo, comparativo porque las mediciones de hábitos alimentarios se realizaron antes y después del confinamiento. Se evaluó el estado nutricional a través del IMC de 57 Adultos Mayores, tomando sus medidas antropométricas, además se aplicó la encuesta de la calidad de la alimentación (ECAAM). Se identificó que el 70,2% de la muestra pertenecen al sexo femenino. Las medias y desviaciones estándar de las variables edad, peso, talla e IMC fueron 76,3 ± 6,46 años; 49,5 ± 8,12 kg; 1,45 ± 0,07 m; 23,7 ± 4,09 kg/m2, respectivamente; resultando que el 66,7% de la población ostenta un estado nutricional normal. La calidad de la alimentación estuvo predominantemente marcada por hábitos alimentarios no saludables, antes y después del confinamiento; 80.7% de la población obtuvo mala calidad de la alimentación antes, y 71,9% después del confinamiento; asimilando una leve mejoría. Se determinó mediante la prueba estadística t de Student para muestras pareadas un p valor de 0.017<0.05, indicando que hay cambios significativos en la calidad de la alimentación después del confinamiento. No existe relación estadísticamente significativa entre el estado nutricional y sus hábitos alimentarios.
Conocimientos, prácticas en alimentación saludable en hogares de niños de 1 a 5 años del CDI "Santa Anita", Otavalo 2022.
Authors: Reinoso Villalba Diego Andrés , Silva Encalada Carlos Mauricio
Published: January 2024

El cuidado alimentario debe ser permanente en la niñez, ya que a medida que van creciendo, adquieren bases para tener hábitos y estilos de vida saludables. El objetivo fue evaluar los conocimientos y prácticas en alimentación saludable en hogares de niños de 1 a 5 años del Centro de Desarrollo Infantil “Santa Anita”. Estudio descriptivo, con enfoque cuantitativo y de corte transversal; se utilizó un muestreo no probabilístico por conveniencia; el instrumento para la recolección de información fue tipo CAP (conocimientos, actitudes y prácticas) adaptado. Se realizó un pretest antes de la capacitación y un post-test. La muestra fueron 30 personas con edades de 21 a 41 años. Se aplicó estadística descriptiva a los datos y los principales resultados fueron: adultos jóvenes, el 60% instrucción secundaria, el 63% menos de una remuneración básica unificada, y la mayoría con 2 a 3 hijos. Los conocimientos en los participantes tuvieron una puntuación inicial de 8 (bueno) y después de la capacitación alcanzaron 11 puntos (bueno); en donde aplicando el estadístico T-students para muestras pareadas para la comparación de medias de valores numéricos de conocimientos siguieron una distribución normal, valor P inferior a 0,05 significativo. En cuanto a las prácticas hacían hincapié en lo referente a higiene, seguido a esto el consumo de alimentos poco saludables, finalmente se preocupan por el consumo de harinas, azúcar y sal. Se concluye que el desconocimiento en alimentación saludable de los hogares es mínimo, y con la educación nutricional se fortalecieron varios aspectos que se desconocía.
Etiología y resistencia antimicrobiana en pacientes hospitalizados con infección del tracto urinario complicada. Hospital San Vicente de Paúl 2019
Authors: Herrera Almeida Roberto David , Pozo Benavides Jacqueline Andrea , Rodríguez Cervantes Edison Geovanny
Published: January 2024

La infección del tracto urinario complicada (ITUc) es una causa común de hospitalización a nivel global. Existen protocolos de manejo de la ITUc adaptados a la epidemiología específica de cada entorno hospitalario, como lo respalda el enfoque local de este estudio.  Objetivo: Describir los agentes etiológicos, el perfil de sensibilidad y resistencia antimicrobiana de la infección del tracto urinario complicada de pacientes ingresados en el servicio de medicina interna. Metodología: Estudio, de tipo observacional y descriptivo de corte transversal, se llevó a cabo en pacientes mayores de 18 años hospitalizados en el Servicio de Medicina Interna, con un total de 138 participantes. Se excluyeron gestantes y se incluyeron pacientes con historias clínicas y registros de urocultivos documentados en la institución de salud. Resultados: Durante el período de estudio, se identifican 112 casos de ITUc con urocultivos positivos. Los microorganismos más prevalentes fueron Escherichia coli (84,8%), seguido por Klebsiella pneumoniae (8%), Proteus mirabilis (4,5%) y Pseudomonas aeruginosa (2,7%). Estos cuatro microorganismos mostraron una alta sensibilidad a amikacina, meropenem, fosfomicina y nitrofurantoína. Sin embargo, exhibieron resistencia significativa a Sulfatrimetroprim (48,4%), Ampicilina (47,4%) y Ciprofloxacina (46,3%). Además, se observará una alta resistencia a las cefalosporinas de primera y segunda generación, así como a la ampicilina. Conclusiones: Este estudio destaca que en pacientes mayores de 18 años hospitalizados con ITUc, Escherichia coli es el microorganismo más comúnmente aislado. Además, se evidencia una preocupante resistencia a las quinolonas. Estos resultados subrayan la importancia de una estrategia de manejo eficaz de la ITUc en entornos hospitalarios, teniendo en cuenta la resistencia antimicrobiana.
Direitos e vínculos trabalhistas por incentivos: Estudos sobre a conformidade entre saúde ambiental e a dinâmica organizacional no meio ambiente de trabalho
Authors: Montenegro dos Reis Rhuan Filipe , Dr. Carlos Passos
Published: January 2024

Analisamos as principais disposições que dizem respeito às relações entre saúde, labor e meio ambiente, sob uma abordagem interdisciplinar de revisão bibliográfica narrativa, em tanto visa-se à compreensão das relações entre a regulação trabalhista e a cultura organizacional. Assim, discute-se desde a sistematização da segurança do trabalho e a diagnose dos riscos até a ergonomia e aborda-se, em seção própria, a ecologia do trabalho que propicia interfaces tanto principiológicas quanto preceituais entre direito ambiental e do trabalho, na legislação contemporânea. A hipótese a ser explorada é a de que o meio ambiente de trabalho que transcenda às políticas de comando e controle e necessita, assim, de uma sistematização de seus incentivos. Alista-se, nessa ocasião, achados que compõem o plano zetético e dogmático desse instituto jurídico.
Analyzing Stability and Data Dependence Notions by a Novel Jungck-Type Iteration Method
Authors: ATALAN Yunus , ERBAŞ Esra
Published: January 2024

Finding the ideal circumstances for a mapping to have a fixed point is the fundamental goal of fixed point theory. These criteria can also be used for the structure under investigation. One of this theory’s most well-known theorems, Banach’s fixed point theorem, has been expanded adopting various methods, making it possible to conduct numerous research studies. Thanks to the Jungck-Contraction Theorem, which has been proven through commutative mappings, many fixed point theorems have been obtained using classical fixed point iteration methods and newly defined methods. This study aims to investigate the convergence, stability, convergence rate, and data dependency of the new four-step fixed-point iteration method. Nontrivial examples are also included to support some of the results herein.
Sistem Informasi Wisata Religi di Kota Banjarmasin Berbasis Flutter dan Firebase
Authors: Romadoni Jiki , Hakim Beny Rahman , Rasyid Muhammad
Published: January 2024

Pariwisata religi di Kota Banjarmasin memiliki potensi besar sebagai daya tarik wisatawan. Namun, masih terdapat kendala dalam mencari informasi mengenai wisata religi di Kota Banjarmasin, seperti kurangnya pemusatan informasi, informasi yang terfragmentasi, dan kurangnya informasi yang lengkap dan terperinci. Keterbatasan informasi ini dapat mengurangi minat penziarah untuk mengunjungi lokasi-lokasi makam wali yang kurang terkenal. Penelitian ini bertujuan untuk mengimplementasikan sistem inoformasi wisata religi berbasis Android di Kota Banjarmasin menggunakan framework Flutter dan firebase. Sistem ini dirancang untuk merangkum semua informasi yang tersedia dari internet dan pengelola tempat wisata religi di Banjarmasin. Sistem ini akan memberikan informasi lengkap tentang fasilitas, rute, sejarah, dan daya tarik dari setiap makam wali serta kegiatan keagamaan terkait. Sistem ini dibangun menggunakan bahasa Dart dan framework Flutter. Metode yang digunakan dalam penelitian ini adalah menggunakan waterfall. Metode waterfall terdiri dari lima tahapan yaitu analisis, desain, kode, pengujian dan pemeliharaan. Pengujian sistem dilakukan menggunakan blackbox testing.
Pengembangan Sistem Informasi Antrian Pasien Menggunakan Technology Acceptance Model
Authors: Widyassari Adhika Pramita , Sirojunnafis Ahmad
Published: January 2024

Praktik Dokter Edi merupakan salah satu klinik kesehatan yang memberikan layanan manajemen pengelolaan informasi yang masih menggunakan sistem manual, termasuk dalam hal pendaftaran antriannya. Tentu satu proses ini merepotkan, membutuhkan waktu yang lama dan membuat ketidaknyamanan untuk pengguna baik pasien maupun petugas. Sehingga penelitian ini bertujuan untuk mengimplementasikan Technology Acceptance Model (TAM) dalam Sistem Informasi Antrian Pasien. TAM digunakan untuk menilai bahwa Sistem informasi antrian pasien yang dibangun apakah benar-benar sesuai dengan tujuan yang diharapkan atau tidak dengan memperhatikan persepsi dan sikap yaitu aspek kegunaan, aspek kemudahan, dan aspek sikap terhadap penggunaan sistem. Dari responden 20 orang, dengan menggunakan pengujian TAM didapatkan hasil rata-rata responden yang Sangat Setuju pada aspek kemudahan pengguna sebesar 61,67%, aspek kegunaan sebesar 63,75%, dan aspek sikap pengguna sebesar 60%.
TIKTOK ACCOUNT BRANDING TECHNIQUE FOR MONETIZATION
Authors: Diana Novita  , Pratiwi Pratiwi , Moch Maulana Anton
Published: January 2024

Right now, surfing social media has gotten to be an auxiliary require in way of life. Right now, numerous individuals like Tiktok social media since this social media could be a. media that presents audio and visual substance. Right now, TikTok isn't as it were utilized to appear engaging substance, but there's moreover a parcel of instructive substance and indeed promoting promotions for items. So that each substance we transfer on TikTok can get great engagement to monetize our TikTok account, we got to brand it or construct our claim individual branding. There are certain ways to construct individual branding . For illustration, building account character, making unique substance and numerous others. Making unique substance implies making substance absolutely from your claim work, not plagiarizing or replicating other people's work. Indeed in the event that we copy at that point apply the ATM show, watch impersonation and adjustment. This ATM show can moreover be categorized as unique substance. The point of the inquire about is to decide the utilize of Tik Tok as individual branding. The inquire about employments subjective strategies with a graphic approach. The inquire about employments subjective strategies with a graphic approach. The comes about of the investigate are to discover out the comes about of actualizing individual branding built by substance makers on TikTok
Impact of the Publicization of Corporate Culture on the Internet on the Financial and Economic Indicators of Courier Companies in Bulgaria
Authors: Minkov Ilian , Ivanov Yordan
Published: January 2024

In the current conditions of a dynamic and highly competitive market environment, the official corporate culture of companies published online plays an essential role in building up their image. However, the question of importance for the managers of business organizations is whether and to what extent the scope of publicization of corporate culture elements affects their market performance and financial and economic results. The purpose of this study is to establish the relationship between the degree of development of the publicized corporate culture of courier companies in Bulgaria and the level of their profitability as a key financial and economic indicator. The results show that, depending on the nature of the proclaimed elements, the publicized corporate culture exerts between a weak and a significant influence on the sales revenue of the studied companies.
Diseño de un prototipo de chasis de ancho variable para una cultivadora agrícola
Authors: Martínez-Martínez Carlos Roberto , Cortés-Leiva Rommel Raeder , Juárez-Osorio Alexander Adolfo
Published: January 2024

Se presenta el diseño de un chasis para una cultivadora agrícola, con un enfoque en el ajuste rápido del ancho entre surcos, dada la diversidad de anchos de siembra que se encuentran en los campos de El Salvador, y las diversas necesidades que enfrentan los agricultores según el tipo de cultivo, el sistema de riego y la maquinaria disponible. Se propone un nuevo diseño de chasis que permite un ajuste rápido y preciso del ancho entre surcos, al mismo tiempo que soporte las condiciones adversas del terreno y facilita el trabajo del operador.

Se utilizó una metodología híbrida que combina el análisis de resultados de operación de una máquina de prueba, previamente desarrollada, y el diseño teórico de nuevas características para el ajuste variable, utilizando ecuaciones de ingeniería mecánica para realizar cálculos de eficiencia del implemento, la distribución de esfuerzos en el chasis, las fuerzas cortantes en los pernos y los requisitos de potencia.

Los resultados confirman la viabilidad operativa del diseño propuesto, como un primer acercamiento sobre la temática de evaluación del diseño; materiales y resistencias de cultivadoras agrícolas, a su vez que orientan el futuro desarrollo de prototipos para pruebas en terreno. Esta investigación sienta las bases para el desarrollo de implementos agrícolas innovadores y adaptables con el potencial de mejorar las prácticas agrícolas a nivel nacional, lo que representa una contribución significativa al sector agrícola.