bluuebunny/crossref_metadata_2025 huggingface dataset:
Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade
Authors: Li Chen , Meng Fantao , Lei Yun , Liu Jing , Liu Jing , Zhang Jingyan , Liu Fang , Liu Cuilan , Guo Ming , Lu Xin-Yun
Published: October 2020

Leptin is an adipocyte-derived hormone with pleiotropic functions affecting appetite and mood. While leptin’s role in the regulation of appetite has been extensively studied in hypothalamic neurons, its function in the hippocampus, where it regulates mood-related behaviors, is poorly understood. Here, we show that the leptin receptor (LepRb) colocalizes with brain-derived neurotrophic factor (BDNF), a key player in the pathophysiology of major depression and the action of antidepressants, in the dentate gyrus of the hippocampus. Leptin treatment increases, whereas deficiency of leptin or leptin receptors decreases, total Bdnf mRNA levels, with distinct expression profiles of specific exons, in the hippocampus. Epigenetic analyses reveal that histone modifications, but not DNA methylation, underlie exon-specific transcription of the Bdnf gene induced by leptin. This is mediated by stimulation of AKT signaling, which in turn activates histone acetyltransferase p300 (p300 HAT), leading to changes in histone H3 acetylation and methylation at specific Bdnf promoters. Furthermore, deletion of Bdnf in the dentate gyrus, or specifically in LepRb-expressing neurons, abolishes the antidepressant-like effects of leptin. These findings indicate that leptin, acting via an AKT-p300 HAT epigenetic cascade, induces exon-specific Bdnf expression, which in turn is indispensable for leptin-induced antidepressant-like effects.
Activation of mTORC1 by LSECtin in macrophages directs intestinal repair in inflammatory bowel disease
Authors: Li Qian , cheng Hanxing , Liu Yuanping , Wang Xiaowen , He Fuchu , Tang Li
Published: October 2020

Damage to intestinal epithelial cells and the induction of cellular apoptosis are characteristics of inflammatory bowel disease. The C-type lectin receptor family member LSECtin promotes apoptotic cell clearance by macrophages and induces the production of anti-inflammatory/tissue growth factors, which direct intestinal repair in experimental colitis. However, the mechanisms by which the phagocytosis of apoptotic cells triggers the pro-repair function of macrophages remain largely undefined. Here, using immunoprecipitation in combination with mass spectrometry to identify LSECtin-interacting proteins, we found that LSECtin interacted with mTOR, exhibiting a role in activating mTORC1. Mechanistically, apoptotic cells enhance the interaction between LSECtin and mTOR, and increase the activation of mTORC1 induced by LSECtin in macrophages. Elevated mTORC1 signaling triggers macrophages to produce anti-inflammatory/tissue growth factors that contribute to the proliferation of epithelial cells and promote the reestablishment of tissue homeostasis. Collectively, our findings suggest that LSECtin-dependent apoptotic cell clearance by macrophages activates mTORC1, and thus contributes to intestinal regeneration and the remission of colitis.
Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition
Authors: Quaresma Margarida C. , Pankonien Ines , Clarke Luka A. , Sousa Luís S. , Silva Iris A. L. , Railean Violeta , Doušová Tereza , Fuxe Jonas , Amaral Margarida D.
Published: October 2020

Cystic fibrosis (CF) is a monogenetic disease resulting from mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene encoding an anion channel. Recent evidence indicates that CFTR plays a role in other cellular processes, namely in development, cellular differentiation and wound healing. Accordingly, CFTR has been proposed to function as a tumour suppressor in a wide range of cancers. Along these lines, CF was recently suggested to be associated with epithelial–mesenchymal transition (EMT), a latent developmental process, which can be re-activated in fibrosis and cancer. However, it is unknown whether EMT is indeed active in CF and if EMT is triggered by dysfunctional CFTR itself or a consequence of secondary complications of CF. In this study, we investigated the occurrence of EMT in airways native tissue, primary cells and cell lines expressing mutant CFTR through the expression of epithelial and mesenchymal markers as well as EMT-associated transcription factors. Transepithelial electrical resistance, proliferation and regeneration rates, and cell resistance to TGF-β1induced EMT were also measured. CF tissues/cells expressing mutant CFTR displayed several signs of active EMT, namely: destructured epithelial proteins, defective cell junctions, increased levels of mesenchymal markers and EMT-associated transcription factors, hyper-proliferation and impaired wound healing. Importantly, we found evidence that the mutant CFTR triggered EMT was mediated by EMT-associated transcription factor TWIST1. Further, our data show that CF cells are over-sensitive to EMT but the CF EMT phenotype can be reversed by CFTR modulator drugs. Altogether, these results identify for the first time that EMT is intrinsically triggered by the absence of functional CFTR through a TWIST1 dependent mechanism and indicate that CFTR plays a direct role in EMT protection. This mechanistic link is a plausible explanation for the high incidence of fibrosis and cancer in CF, as well as for the role of CFTR as tumour suppressor protein.
A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
Authors: Benz Maximilian , Asperger Arndt , Hamester Meike , Welle Alexander , Heissler Stefan , Levkin Pavel A.
Published: October 2020

Acceleration and unification of drug discovery is important to reduce the effort and cost of new drug development. Diverse chemical and biological conditions, specialized infrastructure and incompatibility between existing analytical methods with high-throughput, nanoliter scale chemistry make the whole drug discovery process lengthy and expensive. Here, we demonstrate a chemBIOS platform combining on-chip chemical synthesis, characterization and biological screening. We developed a dendrimer-based surface patterning that enables the generation of high-density nanodroplet arrays for both organic and aqueous liquids. Each droplet (among > 50,000 droplets per plate) functions as an individual, spatially separated nanovessel, that can be used for solution-based synthesis or analytical assays. An additional indium-tin oxide coating enables ultra-fast on-chip detection down to the attomole per droplet by matrix-assisted laser desorption/ionization mass spectrometry. The excellent optical properties of the chemBIOS platform allow for on-chip characterization and in-situ reaction monitoring in the ultraviolet, visible (on-chip UV-Vis spectroscopy and optical microscopy) and infrared (on-chip IR spectroscopy) regions. The platform is compatible with various cell-biological screenings, which opens new avenues in the fields of high-throughput synthesis and drug discovery.
ROS networks: designs, aging, Parkinson’s disease and precision therapies
Authors: N. Kolodkin Alexey , Sharma Raju Prasad , Colangelo Anna Maria , Ignatenko Andrew , Martorana Francesca , Jennen Danyel , Briedé Jacco J. , Brady Nathan , Barberis Matteo , Mondeel Thierry D. G. A. , Papa Michele , Kumar Vikas , Peters Bernhard , Skupin Alexander , Alberghina Lilia , Balling Rudi , Westerhoff Hans V.
Published: October 2020

How the network around ROS protects against oxidative stress and Parkinson’s disease (PD), and how processes at the minutes timescale cause disease and aging after decades, remains enigmatic. Challenging whether the ROS network is as complex as it seems, we built a fairly comprehensive version thereof which we disentangled into a hierarchy of only five simpler subnetworks each delivering one type of robustness. The comprehensive dynamic model described in vitro data sets from two independent laboratories. Notwithstanding its five-fold robustness, it exhibited a relatively sudden breakdown, after some 80 years of virtually steady performance: it predicted aging. PD-related conditions such as lack of DJ-1 protein or increased α-synuclein accelerated the collapse, while antioxidants or caffeine retarded it. Introducing a new concept (aging-time-control coefficient), we found that as many as 25 out of 57 molecular processes controlled aging. We identified new targets for “life-extending interventions”: mitochondrial synthesis, KEAP1 degradation, and p62 metabolism.
Microvascular impairment as a biomarker of diabetic retinopathy progression in the long-term follow up in type 1 diabetes
Authors: Scarinci Fabio , Picconi Fabiana , Virgili Gianni , Varano Monica , Giorno Paola , Frontoni Simona , Parravano Mariacristina
Published: October 2020

This study aimed to explore differences in vascular and structural parameters using optical coherence tomography angiography in patients with type 1 diabetes (DM1) with mild signs of diabetic retinopathy (DR) over a two-year follow-up period. Parafoveal vessel density (PVD) and foveal avascular zone (FAZ) area were analyzed. The thickness of three predefined retinal slabs was measured, including the inner limiting membrane (ILM)–inner plexiform layer (IPL), IPL–inner nuclear layer (INL), and the IPL–outer nuclear layer (ONL). Twenty-two patients with DM1 and 21 controls were included. There was no significant difference in the FAZ area, perimeter and acircularity index between cohorts over time. Baseline superficial capillary plexus PVD was approximately 10% lower in patients with diabetes than in controls (p = 0.001), and was 12% lower at 2 years (p = 0.002). There was no difference in the annual linear trend between the groups (− 0.5% in diabetics vs. controls, p = 0.736). Baseline deep capillary plexus (DCP) PVD was slightly lower in diabetics than in controls (− 4.4%, p = 0.047) and the difference increased at 2 years (− 12.6%, p < 0.001). The annual linear trend was − 2.7% in diabetic patients compared to controls (p = 0.009). In addition, the PVD of the DCP and the intermediate capillary plexus (ICP) were evaluated separately. Regarding the DCP PVD, no statistically significant difference at any time points in diabetic patients compared to controls and no statistically significant difference in the linear trend was found (p > 0.1). Conversely, no difference was recorded for parafoveal ICP density at individual time points (p > 0.1), but a statistically significant difference in the linear trend over time in diabetic patients compared to controls was recoded (− 3.2% per year, p = 0.001). Despite the apparent intergroup differences at baseline in structural OCT parameters, the differences including ILM–IPL (p = 0.273), IPL–INL (p = 0.708), and IPL–ONL (p = 0.054) were modest and not statistically significant with time. Therefore, the microvascular change of the deeper vessels might be a robust biomarker to evaluate the clinical progression of DR in DM1.
Predictive assembling model reveals the self-adaptive elastic properties of lamellipodial actin networks for cell migration
Authors: Chen Xindong , Zhu Hanxing , Feng XiQiao , Li Xiaona , Lu Yongtao , Wang Zuobin , Rezgui Yacine
Published: October 2020

Branched actin network supports cell migration through extracellular microenvironments. However, it is unknown how intracellular proteins adapt the elastic properties of the network to the highly varying extracellular resistance. Here we develop a three-dimensional assembling model to simulate the realistic self-assembling process of the network by encompassing intracellular proteins and their dynamic interactions. Combining this multiscale model with finite element method, we reveal that the network can not only sense the variation of extracellular resistance but also self-adapt its elastic properties through remodeling with intracellular proteins. Such resistance-adaptive elastic behaviours are versatile and essential in supporting cell migration through varying extracellular microenvironments. The bending deformation mechanism and anisotropic Poisson’s ratios determine why lamellipodia persistently evolve into sheet-like structures. Our predictions are confirmed by published experiments. The revealed self-adaptive elastic properties of the networks are also applicable to the endocytosis, phagocytosis, vesicle trafficking, intracellular pathogen transport and dendritic spine formation.
Summary and Outlook
Authors: Ying Yi-Lun , Lu Si-Min , Wang Jiajun , Long Yi-Tao
Published: October 2020

Measurement science has been stepping into single entity sensing. Nanopore electrochemistry as a powerful technique is attracting increasing attention for identifying and characterizing single cells, single particles, and even single molecules. Over the past decades, the biological nanopore-based single biomolecule interface has been extensively applied in probing nucleic acids and biomolecular interactions. Thanks to the advanced material science, the development of solid-state nanopores has been greatly promoted, showing new capabilities and features in single molecule analysis and single particle detection. Recently, nanopipettes have exhibited a great advantage in confining strong interactions between pore and analyte, electron-transfer processes and light inside, giving rise to the possibility of adopting nanopore sensing in a wide range of applications, including single-cell manipulating and analysis. Along with the development of nanopore electrochemistry, new data algorithms and high bandwidth instrumentation have also enabled researchers to look deeply into the intrinsic properties of single entities and therefore to associate them with chemical or biological processes. In future, nanopore electrochemistry will open up a new avenue for the better understanding of the chemical and biological world at the single entity level.
Retracted Article: Chemical synthesis and antigenic activity of a phosphatidylinositol mannoside epitope from Mycobacterium tuberculosis
Authors: Zhao Shi-Yuan , Li Na , Luo Wan-Yue , Zhang Nan-Nan , Zhou Rong-Ye , Li Chen-Yu , Wang Jin
Published: October 2020

Non-natural PIM epitope Ac2PIM2 was presented by CD1b to active T cell to release IFN-γ.
Crystal engineering construction of caffeic acid derivatives with potential applications in pharmaceuticals and degradable polymeric materials
Authors: Wang Zhihan , Flores Quinton , Guo Hongye , Trevizo Raquel , Zhang Xiaochan , Wang Shihan
Published: October 2020

Caffeic acid derivatives with absolute stereostructure were constructed using crystal engineering strategies and topochemical cycloaddition reaction.
Quantum algorithm for simulating molecular vibrational excitations
Authors: Jahangiri Soran , Arrazola Juan Miguel , Quesada Nicolás , Delgado Alain
Published: October 2020

We introduce a quantum algorithm for simulating molecular vibrational excitations during vibronic transitions. The algorithm is used to simulate vibrational excitations of pyrrole and butane during photochemical and mechanochemical excitations.
Analysis and visualization of energy densities. II. Insights from linear-response time-dependent density functional theory calculations
Authors: Pei Zheng , Yang Junjie , Deng Jingheng , Mao Yuezhi , Wu Qin , Yang Zhibo , Wang Bin , Aikens Christine M. , Liang Wanzhen , Shao Yihan
Published: October 2020

Inspired by the analysis of Kohn–Sham energy densities by Nakai and coworkers, we extended the energy density analysis to linear-response time-dependent density functional theory (LR-TDDFT) calculations.
Single atom-doped arsenene as electrocatalyst for reducing nitrogen to ammonia: a DFT study
Authors: Xu Ziwei , Song Ruofei , Wang Mingyuan , Zhang Xiangzhao , Liu Guiwu , Qiao Guanjun
Published: October 2020

A single metal atom-doped 2D material, arsenene, presents potential properties of catalyzing gaseous N2 to ammonia (NH3) under ambient conditions.
Influence of soluble oligomeric aluminum on precipitation in the Al–KOH–H2O system
Authors: Dembowski Mateusz , Graham Trent R. , Reynolds Jacob G. , Clark Sue B. , Rosso Kevin M. , Pearce Carolyn I.
Published: October 2020

Combination of solution state Raman and 27Al NMR spectroscopic measurements paired with elemental analysis reveal a strong correlation between the quantity of soluble Al in caustic solutions and the extent of oligomerization.
Adsorption, diffusion and aggregation of Ir atoms on graphdiyne: a first-principles investigation
Authors: Liu Xin , Xu Meng , Han Yu , Meng Changgong
Published: October 2020

Shifting the atomic diffusion thermodynamics, e.g. with involvement reactants, etc., would initiate the thermodynamically favorable aggregation of Ir atoms into clusters on graphdiyne.
Electrocatalyst design for aprotic Li–CO2 batteries
Authors: Zhang Zhen , Bai Wen-Long , Wang Kai-Xue , Chen Jie-Sheng
Published: October 2020

Electrocatalyst design is reviewed in terms of intrinsic and extrinsic factors. Additionally, potential AI-/descriptor-based search for materials is discussed.
Differences in oral processing behavior of consumers varying in age, gender and ethnicity lead to changes in bolus properties but only to small differences in dynamic texture perception of sausages
Authors: Aguayo-Mendoza Monica G. , Martinez-Almaguer Eduardo F. , Piqueras-Fiszman Betina , Stieger Markus
Published: October 2020

Consumer characteristics such as age, gender and ethnicity influence oral processing behavior through consumption time.
Supercritical methanol depolymerization and hydrodeoxygenation of pyrolytic lignin over reduced copper porous metal oxides
Authors: Li Jian , Galebach Peter H. , Johnson Jillian K. , Fredriksen Tom , Wittrig Ashley , Bai Xiaowei , Yang Haiping , Huber George W.
Published: October 2020

Supercritical methanol depolymerization and hydrodeoxygenation (SCM-DHDO) is a process to produce fuel from biomass with supercritical methanol and CuMgAlOx catalyst.
A mathematical model for deep ion implantation depth profiling by synchrotron radiation grazing-incidence X-ray fluorescence spectrometry
Authors: Czyzycki Mateusz , Kokkoris Mike , Karydas Andreas-Germanos
Published: October 2020

Grazing-incidence X-ray fluorescence is applied to obtain shallow depth distributions using the X-ray standing wave (XSW). A new XSW-free mathematical model is proposed that allows the quantitative derivation of much deeper depth distributions.
Multiplex surface-enhanced Raman scattering detection of deoxynivalenol and ochratoxin A with a linear polymer affinity agent
Authors: Rodriguez Rebeca S. , Szlag Victoria M. , Reineke Theresa M. , Haynes Christy L.
Published: October 2020

A linear, methacrylamide polymer affinity agent was explored to capture two mycotoxins, deoxynivalenol (DON) and ochratoxin A (OTA), for multiplex surface-enhanced Raman scattering (SERS) detection.
Detection and beyond: challenges and advances in aptamer-based biosensors
Authors: Yoo Hyebin , Jo Hyesung , Oh Seung Soo
Published: October 2020

This review provides insight into how current problems of biosensors can be solved by the use of nucleic acid aptamers.
Self-assembled Janus plasmene nanosheets as flexible 2D photocatalysts
Authors: Fu Runfang , Shi Qianqian , Yong Zijun , Griffith James C. , Yap Lim Wei , Cheng Wenlong
Published: October 2020

A 2D flexible photocatalyst has been designed based on Janus plasmene nanosheets for continuous solar-to-chemical conversion.
Proteomic analysis of cisplatin- and oxaliplatin-induced phosphorylation in proteins bound to Pt–DNA adducts
Authors: Yuan Xin , Zhang Wanjun , He Yafeng , Yuan Jian , Song Dongfan , Chen Hao , Qin Weijie , Qian Xiaohong , Yu Hanyang , Guo Zijian
Published: October 2020

Cisplatin and oxaliplatin are widely used anti-tumour chemotherapeutic agents with different spectra of activity. The therapeutic efficacy of such platinum-based drug is believed to, at least in part, result from formation of Pt–DNA adducts, followed by DNA damage response and ultimately apoptosis. However, it remains unclear whether these DNA lesions caused by cisplatin and oxaliplatin elicit distinct reactions in cellular signaling pathways. Here, a label-free comparative proteomic study was performed to profile the protein phosphorylation patterns using Pt–DNA probes with different ligand identities and geometries. Phosphorylated proteins recognizing different cisplatin- and oxaliplatin–DNA lesions were enriched and analyzed on LC-MS/MS. Proteomic analysis revealed that cisplatin mainly affected proteins involved in mRNA processing, while chromatin organization and rRNA processing are two major biological processes influenced by oxaliplatin. Changes to site-specific phosphorylation levels of two proteins YBX1 and UBF1 were also validated by Western blotting. In particular, platinum drug treatment in colon and liver cancer cell lines down-regulated S484 phosphorylation of UBF1, which is an essential transcription factor responsible for ribosomal DNA transcription activation, implying that inhibition of ribosome biogenesis might be involved in the cytotoxic mechanism of platinum drugs. Collectively, these results directly reflected distinct protein phosphorylation patterns triggered by cisplatin and oxaliplatin, and could also provide valuable resources for future mechanistic studies of platinum-based anti-tumour agents.
Multi-step proportional miniaturization to sub-micron dimensions using pre-stressed polymer films
Authors: Sayed Shady , Selvaganapathy P. Ravi
Published: October 2020

Multi-step miniaturization to sub-micron dimensions using shrinkable polymer films.
Simultaneous electrosynthesis of Cu–BTC and Zn–BTC metal–organic frameworks on brass
Authors: Jabarian Sedigheh , Ghaffarinejad Ali
Published: October 2020

Cu–BTC/Zn–BTC was electrosynthesized simultaneously and in situ on brass at room temperature and in a short time.
Hardware implementation of photoelectrically modulated dendritic arithmetic and spike-timing-dependent plasticity enabled by an ion-coupling gate-tunable vertical 0D-perovskite/2D-MoS2hybrid-dimensional van der Waals heterostructure
Authors: Cheng Yongchao , Shan Kexiang , Xu Yan , Yang Junliang , He Jun , Jiang Jie
Published: October 2020

A gate-tunable hybrid-dimensional heterojunction is reported for emulating Boolean logics and dendritic integrations by combining electric and photonic stimuli.
Size-dependent fracture behavior of GaN pillars under room temperature compression
Authors: Fan Sufeng , Li Xiaocui , Fan Rong , Lu Yang
Published: October 2020

Single crystalline GaN pillars are characterized byin situcompression tests inside electron microscopes, showing distinct size-dependent fracture behavior at room temperature for potential microelectronics, power device and MEMS applications.
A comparison between superhydrophobic surfaces (SHS) and slippery liquid-infused porous surfaces (SLIPS) in application
Authors: Wang Chenghong , Guo Zhiguang
Published: October 2020

Inspired by natural phenomena, a comparison of the various applications and performances of superhydrophobic surfaces (SHS) and slippery liquid infused porous surfaces (SLIPS) has been introduced for the design and manufacture of SLIPS systems.
Molecular hot spots in surface-enhanced Raman scattering
Authors: Li Ming , Cushing Scott K. , Zhou Guangwen , Wu Nianqiang
Published: October 2020

This work reports that aromatic molecules adsorbed on the Au surface can create “molecular hot spots” for electromagnetic enhancement of surface-enhanced Raman scattering.
Global accurate diabatic potential surfaces for the reaction H + Li2
Authors: Yin Ruilin , Gao Nan , Cao Jing , Li Yanchun , Wang Dequan , Huang Xuri
Published: October 2020

The adiabatic potential energies for the lowest three states of a Li2H system are calculated with a high levelab initiomethod (MCSCF/MRCI) with a large basis set.
Strong correlation between flux pinning and epitaxial strain in the GdBa2Cu3O7−x/La0.7Sr0.3MnO3 nanocrystalline heterostructure
Authors: Oh J. Y. , Song C. Y. , Ko Y. J. , Lee J. M. , Kang W. N. , Yang D. S. , Kang B.
Published: October 2020

The effect of magnetic flux pinning is investigated in GdBa2Cu3O7 (GdBCO) thin films with two different types of ferromagnetic La0.7Sr0.3MnO3 (LSMO) buffers (nanoparticles and a layer) deposited on an STO substrate.
Polymerization mechanism of 4-APN and a new catalyst for phthalonitrile resin polymerization
Authors: Sheng Liping , Xiang Kerui , Qiu Rong , Wang Yuxuan , Su Shengpei , Yin Dulin , Chen Yongming
Published: October 2020

The IR waterfall plots when the temperature of connection tube of the TG-IR-GC-MS is 300 °C (a) or 50 °C (b). This clearly shows that ammonia gas is produced during the 4-APN cross-linking reaction.
Direct observation of the evolving metal–support interaction of individual cobalt nanoparticles at the titania and silica interface
Authors: Qiu Chengwu , Odarchenko Yaroslav , Meng Qingwei , Cong Peixi , Schoen Martin A. W. , Kleibert Armin , Forrest Thomas , Beale Andrew M.
Published: October 2020

Understanding the metal–support interaction (MSI) is crucial to comprehend how the catalyst support affects performance and whether this interaction can be exploited in order to design new catalysts with enhanced properties.
Photoinduced swing of a diarylethene thin broad sword shaped crystal: a study on the detailed mechanism
Authors: Fujimoto Ayako , Fujinaga Noriko , Nishimura Ryo , Hatano Eri , Kono Luna , Nagai Akira , Sekine Akiko , Hattori Yohei , Kojima Yuko , Yasuda Nobuhiro , Morimoto Masakazu , Yokojima Satoshi , Nakamura Shinichiro , Feringa Ben L. , Uchida Kingo
Published: October 2020

We report a swinging motion of photochromic thin broad sword shaped crystals upon continuous irradiation with UV light.
Effect of lithium incorporation on tweaking the electrocatalytic behavior of tantalum-based oxides
Authors: Shirazi-Amin Alireza , Toloueinia Panteha , Wu Yang , Meguerdichian Andrew G. , Kerns Peter , Suib Steven L.
Published: October 2020

Phase evolution of lithium incorporated tantalum oxides, triggered by Li addition, leads to the change in electrical properties of oxides.
Synthetic polymers based on lignin-derived aromatic monomers for high-performance energy-storage materials
Authors: Yang Weisheng , Wang Xiu , Jiao Liang , Bian Huiyang , Qiao Yongzheng , Dai Hongqi
Published: October 2020

Lignin, a renewable and low-cost biopolymer, has been widely reported as an energy-storage material.
An ionic liquid-infused slippery surface for temperature stability, shear resistance and corrosion resistance
Authors: Chen Yi , Guo Zhiguang
Published: October 2020

The stability of slippery liquid-infused porous surfaces (SLIPSs) is of great significance in long-term applications.
Bismuth-based photocatalysts for solar energy conversion
Authors: Wang Songcan , Wang Lianzhou , Huang Wei
Published: October 2020

Bismuth-based nanomaterials comprise a rich family of narrow bandgap photocatalysts, providing excellent opportunities for converting sunlight into chemical energy. This article is believed to promote the development of efficient photocatalysts.
Synthesis, luminescence enhancement, and self-assembly behaviours of platinum(ii)-containing ABC triblock metallopolymers
Authors: Meng Weisheng , Qiu Xiandeng , Wang Ran , He Qun , Bu Weifeng
Published: October 2020

ABC triblock metallopolymers sequentially consisting of octadecyl and PEG chains and 2,6-bis(benzimidazol-2′-yl)pyridine platinum(ii) complexes can self-assemble into micellelike aggregates in solution, showing remarkable luminescence enhancement.
Elaborately manufacturing an electrochemical aptasensor based on gold nanoparticle/COF composites for amplified detection performance
Authors: Zhu Qian-Qian , Zhang Wen-Wen , Zhang Han-Wen , Yuan Rongrong , He Hongming
Published: October 2020

An electrochemical aptasensor based on Au@COF is designed and fabricated with excellent electrochemical detection performance.
Research on the performance of recycled concrete powder self-leveling mortar based on orthogonal experiment
Authors: Lin Yuezhong , Zhang Xingxing , Wang Yachao
Published: October 2020

Waste concrete in the construction waste is reprocessed into concrete sand and powder [1]. Recycled concrete sand with a particle size between 0.15 and 0.25mm partially replaces natural sand, and the recycled concrete powder with a particle size less than 0.075mm partially replaces cement. The five-factor four-level orthogonal experiment was used to study the replacement amount of recycled concrete powder, the replacement amount of recycled concrete sand, the amount of dispersible latex powder, the amount of polycarboxylate water-reducing agent, the ratio of bone cement, and the five factors on the fluidity of self-leveling mortar. The influence of the three performance indicators of bond tensile strength and dimensional change rate; through the range analysis of the above indicators. The analysis results show that the content of recycled concrete powder instead of cement has the greatest impact on the tensile bond strength and dimensional change rate of recycled concrete powder self-leveling mortar, and the content of Polycarboxylate Superplasticizer has the greatest influence on the fluidity.
Time-history Analysis of a New Assembly Frame with Steel-concrete Composite Lattice Column
Authors: Zhao Yafei , Peng Xiaotong , Man Jie , Lin Chen , Zhang Xu
Published: October 2020

A new assembly steel-concrete composite lattice column frame (SLCF) was proposed as a solution for prefabricated steel structure residential. In order to study the seismic performance of SLCF, a non-linear finite element model under bidirectional ground motion was established by using Sap2000. Based on that, the model of SCLF, reinforced concrete structure and steel frame structure was compared. The results indicate that SCLF has the better strength, lateral stiffness and energy dissipation capacity.
Research of friction characteristics on the hydraulic transportation in inclined slurry-pipe
Authors: Tieli Wang
Published: October 2020

By analyzing the momentum transfer and velocity both of solid particles and water over the acceleration time of solid particles, as well as interaction mechanism between water and solid particals, a new model is proposed to predict friction loss for setting slurry flow in inclined pipe. The hydraulic gradient formula for inclined pipes summarized by the author is confirmed by a large amount of experimental data. The results show that the deviation between the theoretical value of the model proposed by the author and the measured value is not more than 13.33%, which is the smallest among all reports.
Mechanical response of fiber-reinforced sand under cyclic loading
Authors: Li Gang , Zhang Jinli , Liu Jia
Published: October 2020

Based on the consolidated undrained test under cyclic loading, the mechanical response of fiber-reinforced sand under cyclic loading was studied by varying fiber content (0.2% and 0.4%), fiber length (7 mm and 13 mm), and cyclic stress ratio (0.22, 0.24 and 0.26), and the effects of fiber content and fiber length on the excess pore water pressure, dynamic strength and dynamic shear modulus were discussed. The results showed that with the increasing of fiber content, the dynamic strength and liquefaction resistance increased, whereas the accumulation rate of excess pore water pressure decreased. The reduction rate of dynamic shear modulus decreased with the increasing of fiber length, and the dynamic strength decreased with the increasing of cyclic stress ratio, which indicated that the dynamic characteristics of fiber-reinforced sand were better than that of unreinforced sand.
Numerical analysis of the forming process of the bearing capacity of the auxiliary pile foundation in Permafrost area
Authors: Jianzhong Sun , Chunxiang Guo , Xu Wang , Weijia Zhang
Published: October 2020

Bore Cast-in-place Piles broke the original water and heat balance state of the stratum in the bridge construction of Qinghai Tibet railway. The settlement of a bridge pile foundation was relatively large after more than ten years of operation. It was found that there is confined water in the foundation soil after investigation. Engineers planned to add auxiliary piles at the original pile side to reduce the settlement of the pile foundation.This paper studied the temperature change, bearing capacity formation rule and long-term bearing capacity change trend of the new pile-soil system after adding auxiliary piles on the original foundation, which provides certain theoretical basis and reference basis for engineering practice. A three-dimensional model of a bridge pile foundation was established by numerical method. Considering the influence of atmospheric temperature, hydrogeological conditions, concrete temperature into the mold, and the temperature of underground confined water, based on the heat transfer theory, the boundary conditions and initial conditions are given. The influence of the change of ground temperature field and the change of pile-soil interface temperature on the bearing capacity of the foundation was studied after the auxiliary pile was poured. The analysis shows that the measure to increase the bearing capacity by adding auxiliary piles is a double-edged sword. On the one hand, the auxiliary piles themselves constitute the bearing capacity together with the original pile foundation after thawing, on the other hand, the auxiliary piles are constructed by the method of pouring concrete in the field. The hydration heat of concrete makes the temperature of the original foundation soil rise, and reduces its bearing capacity. The whole bearing capacity will not be increased at the initial stage, but also will be temporarily reduced, and the whole bearing capacity will be formed after the frozen soil is frozen back in the later stage.
Structural Health Monitoring Applications in Tall Buildings
Authors: Zhao Yifan
Published: October 2020

Since there is not much research on structural health monitoring (SHM) applications in tall buildings nowadays, this paper gives a proposal of how it can be applied on skyscrapers. Covering the whole process of SHM, this paper focuses more on the diagnostic algorithms, including Structural dynamic index method, Modal parameter identification method Neural network algorithm and Genetic algorithm and how these algorithms can be used in SHM. After introducing the basic process of SHM, an example is given to show how these principles can be applied in this over 400m building. And after all these introductions, a conclusion can be drawn that the structural health monitoring system can be applied properly in tall buildings following the way proposed in this paper.
Comparison of three statistical methods for earthquake-induced landslides susceptibility in Lushan region China
Authors: Liu Rui , Li Luyao , Lai Zili , Yang Xin
Published: October 2020

This paper adopts three models including the logistic regression (LR), support vector machine (SVM), and random forest (RF) to study the susceptibility distribution rule of susceptibility distribution of earthquakes induced landslides. The Area Under the Receiver Operating Characteristic (ROC) curve (AUC) and Ratio were used for evaluating the model’s accuracy and mapping availability susceptibility assessment. The result shows that RF has the best performance in the susceptibility assessment of earthquake-induced landslides in the Lushan region of China.
Semi-analytical solution for consolidation of vertical drain to unsaturated soils considering well resistance and smear effect under time-varying loadings
Authors: Qin Aifang , Jiang Lianghua , Li Linzhong , Li Xinhao
Published: October 2020

In this paper, based on equal-strain assumption a semi-analytical solution, considering well re-sistance, smear effect and time-varying loading, is deduced for radial consolidation aided by vertical drain (VD) to unsaturated soils. Firstly, by employing the general integration, Laplace transform, decoupling methods and numerical inverse Laplace transform, the semi-analytical solution in the time domain is ob-tained. Then, its validity is verified by the special cases of the proposed solution under instantaneous loading. Finally, the case analysis show that the dissipation of excess pore pressures is accelerated with the decrease of smear coefficients (αa or αw) or well resistance factors (Ga or Gw). In addition, when the well resistance factor is less than 1, the barrier of VD material to flow can be ignored. Furthermore, a smaller value of the loading frequency of cyclic loading, the bigger the amplitude, and the less fluctuation period in the dissipa-tion rates. Moreover, the current solution can analyse the consolidation characteristics of unsaturated soils with VDs under arbitrary time-varying loadings, including cyclic loadings.
Study on theater evacuation based on buildingEXODUS
Authors: Meiting Zeng , Daoliang Zhao , Haiming Yang , Li Yang
Published: October 2020

In assembly occupancies with serried seats distribution, such as cinemas and theaters, the evacuation bottleneck is not only limited to the exit but also in the narrow corridors formed by a large number of seats. These narrow corridors are also an important factor that why people cannot evacuate quickly. This paper observes the evacuation situation of a college theater at the end of movies, and uses BuildingEXODUS to study the influence of seat jumping and corridors’ width altering on evacuation. Studies shows that when the number reaches 20%-60% of the capacity, seat jumping situation during evacuation can improve evacuation efficiency. While the number exceeds 60% or less than 20% of the capacity, the total evacuation time will not change significantly. If the total width of the hallway remains unchanged and the width of each hallway is changed, the exit may reach the state of congestion in advance, which aggravates the congestion at the exit and also has a certain impact on the seat jumping to escape.
Application of BIM Technology in Prefabricated Housing Design
Authors: Yanchao Zhao
Published: October 2020

BIM technology applied to the architectural design industry builds a more efficient and scientific building structure model. BIM also improves the design quality of construction projects and ensures the safety and efficiency of building construction. According to the actual situation of a prefabricated residential project, this paper analyzes the BIM design and combination of architecture, structure and equipment on the basis of module system, and puts forward collaborative design and house type split mode. The target is to provide reliable reference for BIM design of similar projects.
Research on Correction Methods of Errors in Multi-beam Sounding Resulted from Water Flow
Authors: Wang Xin
Published: October 2020

The multi-beam sounding system combines multi-beam bathymetry and integrated navigation technology, which can obtain underwater topography data quickly and accurately, it has become the most important way of marine investigation. Therefore, it is urgent for improving the accuracy of sounding system in the detection industry. During the study of multi-beam error processing, the installation error coefficient of transducer installation will be corrected, but all the time, the transducer mounting bracket is regarded would be corrected. However, the transducer mounting bracket has been regarded as a rigid body in the correction for a long time. In this paper, the transducer bracket is regarded as a non-rigid body, and the reversible elastic deformation of transducer bracket occurs due to the impact of water flow. With the change of ship speed and water flow velocity, the degree of elastic deformation is also time-varying. The elastic deformation of bracket leads to the deflection of transducer shafting, which can not be corrected when correcting the installation deviation, so that leading to the influence of this error in final sounding results. This paper aims at the fact of deformation of multi-beam bracket caused by the water flow velocity, ship speed etc., leading to the deflection of transducer relative to the deviation of inertial navigation system shafting and resulting in attitude deviation which affect accuracy of result is researched.
Research on overall risk assessment of Shanchongqing tunnel
Authors: Liu Mingqi , Wang Qiongfen
Published: October 2020

This paper conducts an overall risk assessment of the Shanchongqing Tunnel. The construction of the tunnel project mainly has a huge amount of investment, the construction technology is extremely complicated, and the construction process is extremely time-consuming. Tunnel engineering is greatly affected by geological conditions, and there are a series of unpredictable risk factors during the construction process, whether it is the uncertainty of the surrounding environment, the complexity of the construction process, or the complexity of the geological conditions themselves, all of which are more significant. Once a risk occurs, it will inevitably lead to unpredictable casualties and economic losses. Therefore, risk management is of great significance in the process of project construction.
Finite element analysis of soft foundation treatment by thermal drainage consolidation of group well
Authors: Le Kang , tingjun Zhang , Junhui Tong , Di Chen , Baoyuan Qian
Published: October 2020

Thermal drainage consolidation method is a new technology of soft foundation treatment, which involves the coupling of thermo-hydro-mechanical field, and the action mechanism is complex. In this paper, taking the model test of thermal drainage consolidation as the prototype, the finite element model of thermal drainage consolidation is established by using Abaqus software, then, the numerical results are obtained and are compared with the results of model test, and the reliability of the numerical model is verified. The results show that when the applied load is constant, the higher the temperature is, the faster the consolidation speed of soil is, but with the increase of temperature, the consolidation effect of the same temperature difference will gradually weaken. In addition, the thermal drainage consolidation method can achieve the best treatment effect when the temperature of the soil reaches 60 ℃.
Comparative analysis of stability of large diameter steel cylinder based on FEM and limit equilibrium
Authors: Yu Chang-yi , Lu Ming-yue
Published: October 2020

The stability mechanism of large-diameter steel cylinder under fill load has not yet formed a complete theory. In order to calculate the stability of the steel cylinder island arm structure in a certain project, the limit equilibrium and finite element method are used in this paper. The limit equilibrium method is based on the limit equilibrium of the soil inside and outside the steel cylinder, taking into account the earth pressure and friction force on the cylinder, and using moment equilibrium to calculate its stability coefficient. Secondly, the finite element strength reduction method is adopted to analyze the stability of the steel cylinder island arm structure by using strength parameters to correlate with the temperature field and changing the boundary conditions of the temperature field. The results and analysis methods of this paper provide references for the construction and design of the same type of projects.
The impact of VAM on goodwill impairment —Based on civil engineering construction industry
Authors: Yi Ping
Published: October 2020

Based on the background of the Ministry of Finance’s concern about the issue of goodwill impairment and the frequent outbreak of goodwill impairment risk, this paper analyzes the difference in the proportion of goodwill impairment during the valuation adjustment mechanism ( VAM ) period and after the VAM period, with a view to providing theoretical and data reference suggestions for the standard-setters and regulators on preventing goodwill impairment risk and improving the relevant regime of VAM, and also providing theoretical support and risk warning for stakeholders in M&A. Combining the normative research method and the empirical research method, this paper takes the merger and acquisition event completed by the A-share listed companies of civil engineering construction industry in 2014-2016 as the initial sample, and studies the difference in the proportion of goodwill impairment during the VAM period and after the VAM period. The conclusion of this paper is: In the merger and acquisition transaction with VAM, the proportion of goodwill impairment of listed companies after the VAM period are greater than that of the VAM period.
Exploration of Dancun-Longyang town fault at the site about project of LNG peak shaving station and gas supply pipeline in Luyang Lake
Authors: Ren Fengwen , Li Baolai , Chen Dangming , Li Chunfeng , Tian Weixin
Published: October 2020

In this paper, the method of combining high-density electrical exploration and borehole joint profile is used to explore the Dancun-Longyang town fault at the LNG peak shaving station and gas supply pipeline engineering site of Luyang lake. The distribution and activity of the fault are determined, providing a basis for seismic fortification and seismic geological disaster evaluation in the line
Evaluation of ecological efficiency of resource exhausted cities — a case study of Jilin old industrial base
Authors: Nini Yin
Published: October 2020

Based on DEA theory and window analysis method, this paper empirically measures the ecological efficiency of six resource exhausted cities in Jilin old industrial base from 2012 to 2017, and investigates their regional differences and dynamic evolution characteristics. The results show that: in the sample period, the overall ecological efficiency of Jilin old industrial base is low, but fluctuates slightly; the difference between different urban areas is obvious, while the industrial structure and low level of science and technology inhibit the improvement of ecological efficiency.
LUCC impact on water quality change in Xingyun Lake basin
Authors: Zhang Xiaolun , Shao Yanyan
Published: October 2020

Basin ecological environment and water quality are seriously threatened by development around the lake. The thesis intends to assess basin Land Use and land Cover Changes (here after abbreviated as LUCC) impact on water quality change in Xingyun Lake basin. To achieve this purpose, land use information was interpreted from six periods high-resolution images in the past 30 years, which were classified into seven land use types. The water quality data was obtained by investigation and collection. SPSS software was used to celebrate the correlation coefficient between water quality and LUCC. The results revealed that, in the study area construction land, transportation land and farm land were underwent an increase with the region development; grassland and bare land were gradually reduced, forest land had become fragmented. In addition, the water pollution index gradually increased since 2000, the water deteriorated significantly. Furthermore, there was a strong positive correlation between water pollution indicator and farmland, construction land and transportation land, which indicated that the deterioration of water quality may be the result of the combined effects of agriculture non-point source pollution, domestic and industrial pollution; there was a significant negative correlation between water pollution indicator and grassland and bare land, which indicated that permeable underlying mat had significant interception and absorption effects on pollutants.
Application Problems and Solutions of Intelligent Airport Service Robots
Authors: Yanyan Dai , Meng Chen
Published: October 2020

With the development of new technologies such as artificial intelligence, big data, and cloud computing, the “intelligent airport” is considered to be an effective means to solve or alleviate the current industry problems such as large-scale airport business, the large number of operating entities, and the complicated operation conditions. This paper is about the collaboration between universities and enterprises based on the concept of service design. Relying on big data and cloud computing technology, this paper addresses the problems of airport service robots in inquiries, blind spots of security inspection, and full monomer smart navigation diffluence, combined with the basic technology of service robot artificial intelligence and the third-party interface to design solutions to effectively solve the problems of process.