bluuebunny/crossref_metadata_2025 huggingface dataset:
Phenolic Constituents of Chinese Quince Twigs (Chaenomeles sinensis Koehne) and Their Anti-Neuroinflammatory, Neurotrophic, and Cytotoxic Activities
Authors: Kim Dong Hyun , Subedi Lalita , Kim Hye Ryeong , Choi Sang Un , Kim Sun Yeou , Kim Chung Sub
Published: April 2021

Chaenomeles sinensis has been used as a food and traditional medicines. However, most of research on discovering bioactive constituents from this plant have been focused on its yellow fruit, Chinese quince, due to its wide usage. Here, we isolated and characterized three new phenolic compounds (1, 9, and 11) and 21 known compounds (2−8, 10, and 12−24) from the twigs of C. sinensis. Their chemical structures were established by spectroscopic and spectrometric data analysis including 1D and 2D NMR, high-resolution mass spectrometry (HRMS), electronic circular dichroism (ECD), and LC-MS analysis. Some of the isolated compounds (1−24) showed anti-neuroinflammatory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, neurotrophic activity in C6 cells through the secretion of nerve growth factor (NGF) and/or cytotoxicity against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, MKN-1).
Columbianadin Dampens In Vitro Inflammatory Actions and Inhibits Liver Injury via Inhibition of NF-κB/MAPKs: Impacts on ∙OH Radicals and HO-1 Expression
Authors: Jayakumar Thanasekaran , Hou Shaw-Min , Chang Chao-Chien , Fong Tsorng-Harn , Hsia Chih-Wei , Chen Yen-Jen , Huang Wei-Chieh , Saravanabhavan Periyakali , Manubolu Manjunath , Sheu Joen-Rong , Hsia Chih-Hsuan
Published: April 2021

Columbianadin (CBN), a natural coumarin isolated from Angelica decursiva, is reported to have numerous biological activities, including anticancer and platelet aggregation inhibiting properties. Here, we investigated CBN’s anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cell activation and deciphered the signaling process, which could be targeted by CBN as part of the mechanisms. Using a mouse model of LPS-induced acute liver inflammation, the CBN effects were examined by distinct histologic methods using trichrome, reticulin, and Weigert’s resorcin fuchsin staining. The result showed that CBN decreased LPS-induced expressions of TNF-α, IL-1β, and iNOS and NO production in RAW 264.7 cells and mouse liver. CBN inhibited LPS-induced ERK and JNK phosphorylation, increased IκBα levels, and inhibited NF-κB p65 phosphorylation and its nuclear translocation. Application of inhibitors for ERK (PD98059) and JNK (SP600125) abolished the LPS-induced effect on NF-κB p65 phosphorylation, which indicated that ERK and JNK signaling pathways were involved in CBN-mediated inhibition of NF-κB activation. Treatment with CBN decreased hydroxyl radical (•OH) generation and increased HO-1 expression in RAW 264.7 cells. Furthermore, LPS-induced liver injury, as indicated by elevated serum levels of liver marker enzymes (aspartate aminotransferase (AST) and alanine aminotransferase (ALT)) and histopathological alterations, were reversed by CBN. This work demonstrates the utility of CBN against LPS-induced inflammation, liver injury, and oxidative stress by targeting JNK/ERK and NF-κB signaling pathways.
A Phased Array Antenna with New Elements Designed Using Source Transformations
Authors: Mitra Dipankar , Dev Sukrith , Lewis Jacob , Cleveland Jerika , Allen Monica S. , Allen Jeffery W. , Braaten Benjamin D.
Published: April 2021

Transformation electromagnetics/optics (TE/TO) has been shown to be a useful technique in designing electromagnetic devices with very unique properties. Here, the concepts of transformation optics for single elements is extended to an array of “pinwheel” shaped elements for the first time. Through full-wave finite element analysis (FEA), it is shown that a transformed “pinwheel” linear array can be designed to operate identically to a uniformly spaced linear dipole array. Thus, the “pinwheel” antenna array will maintain all the advantages of array processing of a simple dipole antenna array. The proposed method has applications in structurally integrated and conformal phased arrays for wireless communications, radars, and sensing where structural and mechanical constrains do not align with antenna performance.
A Metawindow with Optimised Acoustic and Ventilation Performance
Authors: Fusaro Gioia , Yu Xiang , Lu Zhenbo , Cui Fangsen , Kang Jian
Published: April 2021

Crucial factors in window performance, such as natural ventilation and noise control, are generally conceived separately, forcing users to choose one over the other. To solve this dualism, this study aimed to develop an acoustic metamaterial (AMM) ergonomic window design to allow noise control without dependence on the natural ventilation duration and vice versa. First, the finite element method (FEM) was used to investigate the noise control performance of the acoustic metawindow (AMW) unit, followed by anechoic chamber testing, which also served as the validation of the FEM models. Furthermore, FEM analysis was used to optimise the acoustic performance and assess the ventilation potential. The numerical and experimental results exhibited an overall mean sound reduction of 15 dB within a bandwidth of 380 to 5000 Hz. A good agreement between the measured and numerical results was obtained, with a mean variation of 30%. Therefore, the AMW unit optimised acoustic performance, resulting in a higher noise reduction, especially from 50 to 500 Hz. Finally, most of the AMW unit configurations are suitable for natural ventilation, and a dynamic tuned ventilation capacity can be achieved for particular ranges by adjusting the window’s ventilation opening. The proposed designs have potential applications in building acoustics and engineering where natural ventilation and noise mitigation are required to meet regulations simultaneously.
Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats
Authors: Snezhkova Elisaveta , Rodionova Natalia , Bilko Dennis , Silvestre-Albero Joaquin , Sydorenko Alexey , Yurchenko Olga , Pakharenko Marharyta , Alavijeh Mo , Bardakhivska Kvitoslava , Riabchenko Natalia , Nikolaev Vladimir
Published: April 2021

Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (SBET ~2700 m2/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment.
Generalized Optimality Criteria Method for Topology Optimization
Authors: Kim Nam H. , Dong Ting , Weinberg David , Dalidd Jonas
Published: April 2021

In this article, a generalized optimality criteria method is proposed for topology optimization with arbitrary objective function and multiple inequality constraints. This algorithm uses sensitivity information to update both the Lagrange multipliers and design variables. Different from the conventional optimality criteria method, the proposed method does not satisfy constraints at every iteration. Rather, it improves the Lagrange multipliers and design variables such that the optimality criteria are satisfied upon convergence. The main advantages of the proposed method are its capability of handling multiple constraints and computational efficiency. In numerical examples, the proposed method was found to be more than 100 times faster than the optimality criteria method and more than 1000 times faster than the method of moving asymptotes.
LDM-Ex-FDM: A Novel Multi-Service Transmission Scheme for the ATSC 3.0 System
Authors: Deng Xianzheng , Bian Xin , Li Mingqi
Published: April 2021

In order to improve system coverage performance, in this paper, a multi-service transmission scheme on the basis of the puncturing technique, namely layered division multiplexing extension frequency-division multiplexing (LDM-Ex-FDM), is proposed. The key idea of the proposed scheme is that the symbols punctured from the enhanced layer (EL) of fixed services will be independently transmitted on a certain number of subcarriers orthogonal to the LDM signal of the core layer (CL) and most of the EL. By doing so, the punctured symbols will be demodulated with a higher signal-to-noise ratio (SNR) on the receiver side and can be recovered well, thus improving the reception performance of the EL fixed services. Moreover, two puncturing strategies based on bit-interleaved coded modulation (BICM) symbols of the LDM-Ex-FDM scheme, namely equal interval symbol puncturing (EISP) and non-equal interval symbol puncturing (NEISP), are developed to improve the performance of the EL services. Simulation results are given to show that, when the puncturing rate in the LDM-Ex-FDM scheme is configured as 1/12, the performance of the fixed service can be improved by 1.8 dB, meanwhile the bit error rate (BER) performance of the mobile service is not affected. Thus, the overall system coverage performance can be improved. Furthermore, to reduce the computational complexity and the demodulation delay of fixed service carried in the EL, at the receiver, a direct interference cancellation (DIC) detector is proposed as well. Simulation results are given to show that, under high injection level and high modulation order, the proposed DIC scheme is able to achieve almost the same BER performance as that of the traditional successive interference cancellation (SIC) scheme while with lower computational complexity.
2-D Seismic Response Analysis of a Slope in the Tyrrhenian Area (Italy)
Authors: Cavallaro Antonio , Ferraro Antonio , Grasso Salvatore , Puccia Antonio
Published: April 2021

The Caronia area is located in the Tyrrhenian north-eastern sector of Sicily (Italy). Starting in 2010, attention focused on the study of landslides phenomena that occurred in this area, which caused significant economic damage to buildings and infrastructures and loss of productive activities. The site is characterized by geotechnical, geological and morphological heterogeneity, and for this reason the site is particularly prone to seismic topographic amplification effects. In this paper, the authors carried out numerical studies focused on the topographic seismic effect evaluation concerning the slope affected by the landslide phenomena. For this site, geotechnical characterization was available concerning both in-situ and laboratory tests; boreholes, piezometers, down-hole tests, multichannel analysis of surface waves tests, seismic tomographies and inclinometer measurements were carried out. Furthermore, 1-D and 2-D local seismic response analyses were carried out by using different synthetic seismograms related to the earthquake of Messina and Reggio Calabria on 28 December 1908. The results of the numerical analyses are presented in terms of response seismograms and response spectra at the surface.
Integrated Approach for Detecting Convection Effects in Geothermal Environments Based on TIR Camera Measurements
Authors: Del Pozo Susana , Sáez Blázquez Cristina , Martín Nieto Ignacio , Lagüela Susana
Published: April 2021

Thermal characterization of soils is essential for many applications, including design of geothermal systems. Traditional devices focus on the computation of thermal conductivity, omitting the analysis of the convection effect, which is important for horizontal geothermal systems. In this paper, a procedure based on the monitoring of the surface of the soil with a thermal infrared (TIR) camera is developed for the evaluation of the global thermal imbalance on the surface and in-depth. This procedure allows for the computation of thermal conductivity and global convection heat rate, consequently constituting a complete thermal characterization of the geothermal system. The validation of the results is performed through the evaluation of the radiometric calibration of the thermal infrared camera used for the monitoring and the comparison of the thermal conductivity values obtained in-depth, with traditional methods, and for the surface of the system.
Transient Analysis of Flow Unsteadiness and Noise Characteristics in a Centrifugal Compressor with a Novel Vaned Diffuser
Authors: Zamiri Ali , Park Kun Sung , Choi Minsuk , Chung Jin Taek
Published: April 2021

The demands to apply transonic centrifugal compressor have increased in the advanced gas turbine engines. Various techniques are used to increase the aerodynamic performance of the centrifugal compressor. The effects of the inclined leading edges in diffuser vanes of a transonic centrifugal compressor on the flow-field unsteadiness and noise generation are investigated by solving the compressible, three-dimensional, transient Navier–Stokes equations. Diffuser vanes with various inclination angles of the leading edge from shroud-to-hub and hub-to-shroud are numerically modeled. The results show that the hub-to-shroud inclined leading edge improves the compressor performance (2.6%), and the proper inclination angle is effective to increase the stall margin (3.88%). In addition, in this study, the transient pressure variations and radiated noise prediction at the design operating point of the compressor are emphasized. The influences of the inclined leading edges on the pressure waves were captured in time/space domain with different convective velocities. The pressure fluctuation spectra are calculated to investigate the tonal blade passing frequency (BPF) noise, and it is shown that the applied inclination angles in the diffuser blades are effective, not only to improve the aerodynamic performance and stall margin, but also to reduce the BPF noise (7.6 dB sound pressure level reduction). Moreover, it is found that the diffuser vanes with inclination angles could suppress the separation regions and eddy structures inside the passages of the diffuser, which results in reduction of the overall sound pressure level and the broadband noise radiated from the compressor.
Design and Validation of an Open Source 3D Printer Based on Digital Ultraviolet Light Processing (DLP), for the Improvement of Traditional Artistic Casting Techniques for Microsculptures
Authors: Saorin Jose Luis , Diaz-Alemán Manuel Drago , De la Torre-Cantero Jorge , Meier Cecile , Pérez Conesa Ithaisa
Published: April 2021

The adoption of open-source digital manufacturing technologies in small art workshops may improve their competitiveness. Pieces modeled by computer and made with FDM (Fused Deposition Modeling) 3D printers that use PLA (polylactic acid) can be implemented in the procedures of artistic casting. However, models printed by PLA are limited to approximate minimum sizes of 3 cm, and the optimal layer height resolution is 0.1 mm. These sizes and resolutions are not suitable for creating microsculptures used, in many cases, in jewelry. An alternative to solve this limitation, is to use a DMLS (Direct Metal Laser Sintering) 3D printer. However, due to its high cost, it is a technology that is difficult to introduce in small artistic foundries. This work detailed the design and validation of a DLP (Digital Light Processing) 3D printer, using backlit LCD (Liquid Crystal Display) screens with ultraviolet light. Its development is totally “open source” and is proposed as a kit made up of electronic components, based on Arduino and easy to access mechanical components in the market. Most parts can be manufactured in low cost FDM (Fused Deposition Modeling) 3D printers. The result is an affordable, high resolution (0.021 mm), and open-design printer that can be implemented in artistic contexts.
Risk Analysis of One-Way Road Tunnel Tube Used for Bi-Directional Traffic under Fire Scenarios
Authors: Caliendo Ciro , Russo Isidoro , Genovese Gianluca
Published: April 2021

We have set up a Computational Fluid Dynamics (CFD) modeling, and performed a user evacuation model, for evaluating the risk level in one-way road tunnel tube when used for bi-directional traffic in particular circumstances. The simulations were carried out by considering both peak-hour traffic volumes during the day and off-peak hours overnight. The investigated one-way tube is ventilated by natural ventilation only, and has a length of less than 1000 m. With reference to the worst environmental conditions, which are downstream of the fire due to the direction of natural ventilation, the consequences on escaping users, caused by different types of burning vehicles located in various longitudinal positions along the tube, are shown. The results prove the positive effects on environmental conditions (in terms of temperature, visibility distance, CO and CO2 concentration) along the user evacuation path when the tube is used for bi-directional traffic at night rather than daytime. Only for the case of 100 MW fire and in the proximity of the exit portal, the last escaping user might be affected by a visibility distance and CO concentration exceeding the threshold values. In this special case, countermeasures for reducing smoke concentration or emergency services at the portals should be provided. However, the quantitative risk analysis, based on a probabilistic approach, showed that the F-N curve of the tube when used for bi-directional traffic with reference to the night always lies below that of the daytime, and the reduction in the risk level is between 80 and 100% for the night traffic compared to daytime one. It is to be focused on the fact that our modeling may represent a reference in investigating the effects of hourly traffic volumes on the risk level in tunnels and may help decisionmakers in understanding when to temporarily close a tube for maintenance, repair, or rehabilitation activities and use the adjacent tube for bi-directional traffic.
Interactions between Cognition and Hearing Aid Compression Release Time: Effects of Linguistic Context of Speech Test Materials on Speech-in-Noise Performance
Authors: Xu Jingjing , Cox Robyn M.
Published: April 2021

Recent research has established a connection between hearing aid (HA) users’ cognition and speech recognition performance with short and long compression release times (RT). Contradictive findings prevent researchers from using cognition to predict RT prescription. We hypothesized that the linguistic context of speech recognition test materials was one of the factors that accounted for the inconsistency. The present study was designed to examine the relationship between HA users’ cognition and their aided speech recognition performance with short and long RTs using materials with various linguistic contexts. Thirty-four older HA users’ cognitive abilities were quantified using a reading span test. They were fitted with behind-the-ear style HAs with adjustable RT settings. Three speech recognition tests were used: the word-in-noise (WIN) test, the American four alternative auditory feature (AFAAF) test, and the Bamford-Kowal-Bench speech-in-noise (BKB-SIN) test. The results showed that HA users with high cognitive abilities performed better on the AFAAF and the BKB-SIN than those with low cognitive abilities when using short RT. None of the speech recognition tests produced significantly different performance between the two RTs for either cognitive group. These findings did not support our hypothesis. The results suggest that cognition might not be important in prescribing RT.
Multiple Optimal Solutions and the Best Lipschitz Constants Between an Aggregation Function and Associated Idempotized Aggregation Function
Authors: Tang Hui-Chin , Chen Wei-Ting
Published: April 2021

This paper presents and compares the optimal solutions and the theoretical and empirical best Lipschitz constants between an aggregation function and associated idempotized aggregation function. According to an exhaustive search we performed, the multiple optimal solutions and the empirical best Lipschitz constants are presented explicitly. The results indicate that differences of the multiple optimal solutions exist among the Minkowski norm, the number of steps, and the type of aggregation function. We demonstrate that these differences can affect the theoretical and empirical best Lipschitz constants of an aggregation function.
GBP5 Repression Suppresses the Metastatic Potential and PD-L1 Expression in Triple-Negative Breast Cancer
Authors: Cheng Shun-Wen , Chen Po-Chih , Lin Min-Hsuan , Ger Tzong-Rong , Chiu Hui-Wen , Lin Yuan-Feng
Published: April 2021

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype because of its high metastatic potential. Immune evasion due to aberrant expression of programmed cell death ligand 1 (PD-L1) has also been reported recently in metastatic TNBC. However, the mechanism underlying metastatic progression and PD-L1 upregulation in TNBC is still largely unknown. Here, we found that guanylate binding protein 5 (GBP5) is expressed in higher levels in TNBC tissues than in non-TNBC and normal mammary tissues and serves as a poorer prognostic marker in breast cancer patients. Transwell cultivation indicated that GBP5 expression is causally related to cellular migration ability in the detected TNBC cell lines. Moreover, the computational simulation of the gene set enrichment analysis (GSEA) program against the GBP5 signature generated from its coexpression with other somatic genes in TNBC revealed that GBP5 upregulation may be associated with the activation of interferon gamma (IFN-γ)-responsive and NF-κB-related signaling cascades. In addition, we found that the coexpression of GBP5 with PD-L1 was significantly positive correlation in TNBC tissues. Robustly, our data showed that GBP5 knockdown in TNBC cells harboring a higher GBP5 level dramatically suppresses the number of migrated cells, the activity of IFN-γ/STAT1 and TNF-α/NF-κB signaling axes, and the expression of PD-L1. Importantly, the signature combining a higher GBP5 and PD-L1 level predicted the shortest time interval of brain metastasis in breast cancer patients. These findings not only uncover the oncogenic function of GBP5 but also provide a new strategy to combat metastatic/immunosuppressive TNBC by targeting GBP5 activity.
Mothers’ Experiences about Decisions to Use Children’s Proton Beam Therapy
Authors: Ozawa Noriko , Fukuzawa Rieko , Furuya Kayuri
Published: April 2021

Recently, proton beam therapy has been recommended in radiation therapy for child-hood cancer. However, facilities for children are limited, and parents who choose this treatment for their children face a variety of challenges. This study reveals mothers’ experiences about the decision to use the aforementioned therapy. A semi-structured interview was conducted with 16 mothers of children who received proton beam therapy in Japan, and a grounded theory approach was adopted. The results revealed that mothers were very worried about late complications concerning their children due to radiation. While the mothers strongly expected proton beam therapy to reduce the risk of late complications, they felt uncertainty and anxiety throughout the entire decision-making process. Despite having to deal with their feelings, they had to transfer to another hospital and prepare support for their children to begin treatment, and this put a lot of strain on them. From decision-making to start of treatment, these emotional fluctuations and the need for psychological support became apparent.
Latent Class Model with Heterogeneous Decision Rule for Identification of Factors to the Choice of Drivers’ Seat Belt Use
Authors: Rezapour Mahdi , Ksaibati Khaled
Published: April 2021

The choice of not buckling a seat belt has resulted in a high number of deaths worldwide. Although extensive studies have been done to identify factors of seat belt use, most of those studies have ignored the presence of heterogeneity across vehicle occupants. Not accounting for heterogeneity might result in a bias in model outputs. One of the main approaches to capture random heterogeneity is the employment of the latent class (LC) model by means of a discrete distribution. In a standard LC model, the heterogeneity across observations is considered while assuming the homogeneous utility maximization for decision rules. However, that notion ignores the heterogeneity in the decision rule across individual drivers. In other words, while some drivers make a choice of buckling up with some characteristics, others might ignore those factors while making a choice. Those differences could be accommodated for by allowing class allocation to vary based on various socio-economic characteristics and by constraining some of those rules at zeroes across some of the classes. Thus, in this study, in addition to accounting for heterogeneity across individual drivers, we accounted for heterogeneity in the decision rule by varying the parameters for class allocation. Our results showed that the assignment of various observations to classes is a function of factors such as vehicle type, roadway classification, and vehicle license registration. Additionally, the results showed that a minor consideration of the heterogeneous decision rule resulted in a minor gain in model fits, as well as changes in significance and magnitude of the parameter estimates. All of this was despite the challenges of fully identifying exact attributes for class allocation due to the inclusion of high number of attributes. The findings of this study have important implications for the use of an LC model to account for not only the taste heterogeneity but also heterogeneity across the decision rule to enhance model fit and to expand our understanding about the unbiased point estimates of parameters.
Proposal for a Methodology for Sustainable Rehabilitation Strategies of the Existing Building Stock—The Ponte Gêa Neighborhood
Authors: Santos Michael M. , Lanzinha João C. G. , Ferreira Ana Vaz
Published: April 2021

Having in mind the objectives of the United Nations Development Agenda 2030, which refers to the sustainable principles of a circular economy, it is urgent to improve the performance of the built environment. The existing buildings must be preserved and improved in order to reduce their environmental impact, in line with the need to revert climate change and reduce the occurrence of natural disasters. This work had as its main goal to identify and define a methodology for promoting the rehabilitation of buildings in the Ponte Gêa neighborhood, in the city of Beira, Mozambique, with an emphasis on energy efficiency, water efficiency, and construction and demolition waste management. The proposed methodology aims to create a decision support method for creating strategic measures to be implemented by considering the three specific domains—energy, water, and waste. This model allows for analyzing the expected improvement according to the action to be performed, exploring both individual and community solutions. It encompasses systems of standard supply that can reveal greater efficiency and profitability. Thus, the in-depth knowledge of the characteristics of urban space and buildings allows for establishing guidelines for the renovation process of the neighborhood.
Occupational Radiation Dose to Eye Lenses in CT-Guided Interventions Using MDCT-Fluoroscopy
Authors: Inaba Yohei , Hitachi Shin , Watanuki Munenori , Chida Koichi
Published: April 2021

In computed tomography (CT)-guided interventions (CTIs), physicians are close to a source of scattered radiation. The physician and staff are at high risk of radiation-induced injury (cataracts). Thus, dose-reducing measures for physicians are important. However, few previous reports have examined radiation doses to physicians in CTIs. This study evaluated the radiation dose to the physician and medical staff using multi detector (MD)CT-fluoroscopy, and attempted to understand radiation-protection and -reduction methods. The procedures were performed using an interventional radiology (IVR)-CT system. We measured the occupational radiation dose (physician and nurse) using a personal dosimeter in real-time, gathered CT-related parameters (fluoroscopy time, mAs, CT dose index (CTDI), and dose length product (DLP)), and performed consecutive 232 procedures in CT-guided biopsy. Physician doses (eye lens, neck, and hand; μSv, average ± SD) in our CTIs were 39.1 ± 36.3, 23.1 ± 23.7, and 28.6 ± 31.0, respectively. Nurse doses (neck and chest) were lower (2.3 ± 5.0 and 2.4 ± 4.4, respectively) than the physician doses. There were significant correlations between the physician doses (eye and neck) and related factors, such as CT-fluoroscopy mAs (eye dose: r = 0.90 and neck dose: r = 0.83). We need to understand the importance of reducing/optimizing the dose to the physician and medical staff in CTIs. Our study suggests that physician and staff doses were not significant when the procedures were performed with the appropriate radiation protection and low-dose techniques.
Power and Thermal Efficiency Optimization of an Irreversible Steady-Flow Lenoir Cycle
Authors: Wang Ruibo , Ge Yanlin , Chen Lingen , Feng Huijun , Wu Zhixiang
Published: April 2021

Using finite time thermodynamic theory, an irreversible steady-flow Lenoir cycle model is established, and expressions of power output and thermal efficiency for the model are derived. Through numerical calculations, with the different fixed total heat conductances (UT) of two heat exchangers, the maximum powers (Pmax), the maximum thermal efficiencies (ηmax), and the corresponding optimal heat conductance distribution ratios (uLP(opt)) and (uLη(opt)) are obtained. The effects of the internal irreversibility are analyzed. The results show that, when the heat conductances of the hot- and cold-side heat exchangers are constants, the corresponding power output and thermal efficiency are constant values. When the heat source temperature ratio (τ) and the effectivenesses of the heat exchangers increase, the corresponding power output and thermal efficiency increase. When the heat conductance distributions are the optimal values, the characteristic relationships of P-uL and η-uL are parabolic-like ones. When UT is given, with the increase in τ, the Pmax, ηmax, uLP(opt), and uLη(opt) increase. When τ is given, with the increase in UT, Pmax and ηmax increase, while uLP(opt) and uLη(opt) decrease.
The VWRCA Index: Measuring a Country’s Comparative Advantage and Specialization in Services. The Case of Poland
Authors: Wosiek Roman , Visvizi Anna
Published: April 2021

In the extant body of literature on the servitization of the economy, on the one hand, and determinants of growth and development, on the other, the classic question of revealed comparative advantage (RCA) plays a prominent role. Regardless of the popularity, relevance, and validity of the use of the RCA as a part of multivariate queries on the above topics, this paper argues that the RCA alone offers a rather static insight into a country’s economic performance. Most importantly, the classic take on the RCA does not allow us to query a country’s comparative advantage and degree of specialization in the services sector. By inserting itself in the broader discussion on ways of bypassing the limitations inherent in the classic RCA index, this paper proposes a novel take on the RCA index, i.e., the Visvizi–Wosiek RCA (VWRCA) index, and, subsequently, applies it to the study of the evolution of the services sector in Poland over the period 2010–2019. The added value of the VWRCA index is threefold. (i) By recognizing the increasing role of services in the global economy, it serves as a useful tool in queries aimed at examining the structure of a given economy, the degree of specialization in the production of certain services, and the real revealed comparative advantage a country has in the production of a certain group/category of services. (ii) By focusing solely on services, the VWRCA index allows us to examine the volume and velocity of trade in services independently from the volume of trade in goods. (iii) Due to the resulting methodological accuracy, it enables the inclusion of a temporal dimension in the analysis, which in turn gives cues as to specific developments and the actual performance of a given economy regarding the evolution of the services sector.
An Interpretable Deep Learning Model for Automatic Sound Classification
Authors: Zinemanas Pablo , Rocamora Martín , Miron Marius , Font Frederic , Serra Xavier
Published: April 2021

Deep learning models have improved cutting-edge technologies in many research areas, but their black-box structure makes it difficult to understand their inner workings and the rationale behind their predictions. This may lead to unintended effects, such as being susceptible to adversarial attacks or the reinforcement of biases. There is still a lack of research in the audio domain, despite the increasing interest in developing deep learning models that provide explanations of their decisions. To reduce this gap, we propose a novel interpretable deep learning model for automatic sound classification, which explains its predictions based on the similarity of the input to a set of learned prototypes in a latent space. We leverage domain knowledge by designing a frequency-dependent similarity measure and by considering different time-frequency resolutions in the feature space. The proposed model achieves results that are comparable to that of the state-of-the-art methods in three different sound classification tasks involving speech, music, and environmental audio. In addition, we present two automatic methods to prune the proposed model that exploit its interpretability. Our system is open source and it is accompanied by a web application for the manual editing of the model, which allows for a human-in-the-loop debugging approach.
Review of Specific Performance Parameters of Vertical Wind Turbine Rotors Based on the SAVONIUS Type
Authors: Fanel Dorel Scheaua , Adrian Mihai Goanta , Nicusor Dragan
Published: April 2021

Increasing energy demand and environmental regulations around the world provide an adequate framework for developing methods of obtaining energy from renewable sources. Wind force is a resource with a high potential through which green energy can be obtained with no negative impact on the environment. Different turbine typologies have been developed, which can convert the wind force into mechanical and electrical energy through turbine rotational motion. Starting from the classic vertical-axis SAVONIUS rotor model, other models have been designed, which, according to the numerical studies and experimental test results, show higher performance parameters in operation. Such models present specific rotor blade geometries to achieve better operational results in terms of shaft torque and generated power. There are multiple research results from numerical analysis on virtual models or experimental tests that use rotor models in different constructive configurations aiming to improve operation performance. These research activities are related to the rotor blade number, the aspect and overlap ratio values, the blade profile geometry modification, the use of end plates connected to the rotor blades, curtain mounting solutions for directing the air flow on the active blade alone, and rotor constructive variants with deformable blades during operation. Some of the results obtained from the mentioned research activities are shown in this review for special rotor configurations whose performance results in terms of torque or power values are compared to the classical SAVONIUS model.
Socio-Ecological Perceptions of Wildfire Management and Effects in Greece
Authors: Palaiologou Palaiologos , Kalabokidis Kostas , Troumbis Andreas , Day Michelle A. , Nielsen-Pincus Max , Ager Alan A.
Published: April 2021

Adapting to the growing frequency of catastrophic wildfires in Greece and mitigating their effects is a complex socio-ecological problem. We used an online survey to query more than 100 engaged stakeholders who can potentially influence possible legislation and fire management organizational reform, emphasizing civil protection agencies and research entities. We focused the questionnaire on the importance of different wildfire effects to understand which were considered negative or unacceptable, indifferent, or positive. For fire prevention, we examined the range of acceptance and views on fuel management and fire use activities that are limited in extent or not allowed in Greece. We also examined the beliefs regarding ignition causes and responsibility, in addition to how different policies might reduce wildfire-related problems. The results revealed an emphasis on reforming wildfire management policies to deal with the way society and agencies function and interact, and mitigate the influence of climate change in wildfire frequency and behavior. In addition, respondents had a negative stance towards allowing wildfires to burn for resource objectives and a strong belief that arsonists are behind most ignitions. They also believe the lack of a national cadaster system is a major source of wildfire-related problems. The results indicate little support for fuel treatments, but increased acceptance for the legalization of fire use during firefighting (backfires). This study summarizes current wildfire perceptions in Greece and identifies opportunities and barriers to changes in wildfire governance to improve risk management programs and guide post-fire management and mitigation.
Dietary Fiber: Fractionation, Characterization and Potential Sources from Defatted Oilseeds
Authors: Nevara Gita Addelia , Muhammad Sharifah Kharidah Syed , Zawawi Norhasnida , Mustapha Nor Afizah , Karim Roselina
Published: April 2021

Dietary fiber (DF) has wide applications, especially in the food and pharmaceutical industries due to its health-promoting effects and potential techno-functional properties in developing functional food products. There is a growing interest in studies related to DF; nevertheless, there is less focus on the fractionation and characterization of DF. The characteristics of DF fractions explain their functionality in food products and provide clues to their physiological effects in food and pharmaceutical industrial applications. The review focuses on a brief introduction to DF and methods for its fractionation. It discusses the characterization of DF in terms of structural, physicochemical and rheological properties. The potential sources of DF from selected defatted oilseeds for future studies are highlighted.
Enzymatic Digestion of Calf Fleshing Meat By-Products: Antioxidant and Anti-Tyrosinase Activity of Protein Hydrolysates, and Identification of Fatty Acids
Authors: Tedeschi Tullia , Anzani Cecilia , Ferri Maura , Marzocchi Silvia , Caboni Maria Fiorenza , Monari Stefania , Tassoni Annalisa
Published: April 2021

The food waste reduction through an efficient recovery of its valuable building molecules has become an important topic with a positive effect on the economy and the environment. In this work, the revalorization of slaughterhouse calf fleshing meat through its enzymatic hydrolysis is proposed. The proteolytic activity of 11 enzymes was initially screened and the four most efficient enzymes (papain, trypsin, pancreatin, and bromelain) were selected. The molecular profiling of the different protein/peptide fractions by the Linear Trap Quadrupole-OrbiTrap technique showed compositional differences due to the specificity of the enzymes’ cleavage sites. In order to find a potential reuse of these hydrolysates, the analysis of antioxidant and, for the first time on fleshing meat hydrolysates, of anti-tyrosinase activities, was performed. Papain-digested samples were those showing the highest inhibition activity of tyrosinase enzyme (55.6%) as well as the highest antioxidant activity (3.52 g TEAC/L). In addition, the composition analysis of the lipid fraction was performed. The mono-unsaturated fatty acids resulted to be the most abundant lipid in all the samples with the exception of pancreatin-treated hydrolysates in which poly-unsaturated fatty acids were predominant. The present results seemed to support a possible valorization of isolated fractions from calf fleshing by-products, as food or feed ingredients, by the implementation of fraction isolation within the meat-processing pipeline.
Comparative Study on Kernel Quality and Chemical Composition of Ancient and Modern Wheat Species: Einkorn, Emmer, Spelt and Hard Red Spring Wheat
Authors: Kulathunga Jayani , Reuhs Bradley L. , Zwinger Steve , Simsek Senay
Published: April 2021

Hulled wheat species are often used as whole grains in processing, and have been attracting attention in the last 20 years in the food industry. Whole wheat flour of hulled wheat can be used in the food industry for value addition. This study was conducted to evaluate the kernel quality and chemical composition of the whole grain flour of hulled wheats as a preliminary approach to use these species for value addition. The experimental design was separate, randomized complete block designs for einkorn, emmer, and spelt, with four field replicates. According to the results, significant differences (p < 0.05) were observed in kernel quality traits, such as test weight, 1000 kernel weight, and kernel hardness, compared to hard red spring wheat. The results of the chemical composition revealed that hulled wheats were characterized by significantly lower (p < 0.05) protein and higher (p < 0.05) crude fat contents compared to whole wheat flour of hard red spring wheat. Among hulled wheats, total dietary fiber content was highest in emmer, followed by einkorn and spelt. In conclusion, the whole wheat flour of einkorn, emmer, and spelt used in this study differ from hard red spring wheat in their kernel quality and chemical composition.
Clinopyroxene Crystals in Basic Lavas of the Marsili Volcano Chronicle Early Magmatic Stages in a Back-Arc Transcrustal Mush System
Authors: Trua Teresa , Marani Michael P.
Published: April 2021

Constraining the pre-eruptive processes that modulate the chemical evolution of erupted magmas is a challenge. An opportunity to investigate this issue is offered by the interrogation of the crystals carried in lavas. Here, we employ clinopyroxene crystals from back-arc lavas in order to identify the processes driving basalt to andesite magma evolution within a transcrustal plumbing system. The assembled clinopyroxene archive reveals that mantle melts injected at the crust-mantle transition cool and crystalize, generating a clinopyroxene-dominated mush capped by a melt-rich domain. Magma extracted from this deep storage zone fed the eruption of basalt to basaltic andesite lavas. In addition, chemically evolved melts rapidly rising from this zone briefly stalled at shallow crustal levels, sourcing crystal-poor andesite lavas. Over time, hot ascending primitive magmas intercepted and mixed with shallower cooling magma bodies forming hybrid basic lavas. The blended clinopyroxene cargoes of these lavas provide evidence for the hybridization, which is undetectable from a whole-rock chemical perspective, as mixing involved chemically similar basic magmas. The heterogeneity we found within the clinopyroxene archive is unusual since it provides, for the first time, a complete set of mush-related scenarios by which mantle melts evolve from basalt to andesite compositions. Neither the whole-rock chemistry alone nor the record of the mineral phases crystallizing subsequent to clinopyroxene can provide insights on such early magmatic processes. The obtained clinopyroxene archive can be used as a template for interpretation of the record preserved in the clinopyroxene cargoes of basalt to andesite lavas elsewhere, giving insights into the magma dynamics of the feeding plumbing system that are lost when using whole-rock chemistry.
The Oral Health Inequities between Special Needs Children and Normal Children in Asia: A Systematic Review and Meta-Analysis
Authors: Ningrum Valendriyani , Bakar Abu , Shieh Tzong-Ming , Shih Yin-Hwa
Published: April 2021

This meta-analysis aimed to analyze the oral health inequalities among special needs children during 2004–2019 in Asia to reveal the importance and the needs of establishing integrated and equitable special needs dentistry care system in Indonesia. PubMed, Scopus, Cochrane Library, Web of Science, and Wiley Online Library were systematically searched for full-text observational studies published from 1 January 2004 to 15 January 2020, in English in Asia. Studies that included children under 18 years of age with special needs and compared them to healthy controls were selected. Study quality was assessed using the Joanna Briggs Institute 2017 Critical Appraisal Checklist. Risk of bias was assessed using the ROBINS-E tool. The decayed, missing, and filled permanent teeth (DMFT) index indicated that special needs children who suffer from intellectual disability or autism spectrum disorder had significantly more caries than normal children (p < 0.001). The special needs children who had more caries than normal children lived in countries that had a high average DMFT value among 12 years old children (p < 0.001), and these two variables showed a positive correlation in meta-regression analysis (p < 0.001). Having an integrated and equitable care system and elevating children’s oral health are important to maintain special needs children’s oral health.
Polyoxymethylene as Material for Removable Partial Dentures—A Literature Review and Illustrating Case Report
Authors: Schierz Oliver , Schmohl Leonie , Hahnel Sebastian , Rauch Angelika
Published: April 2021

Compared to thermoplastic manufacturing techniques, computer-aided design (CAD) and computer-aided manufacturing (CAM) technologies make it easier to process modern restorative and prosthetic materials with improved material properties. In dentistry, tooth-colored alternatives to metal-based frameworks for application in removable dental prostheses (RDP) emerged. With regard to this aspect, the current article provides an overview of the specific material properties of polyoxymethylene (POM). Furthermore, it reviews scientific literature indexed in PubMed and Web of Science that focuses on RDPs fabricated from POM within the last 10 years. Finally, a prosthetic rehabilitation of a patient with a RDP fabricated from POM is illustrated and observations during a follow-up over 10 months are described. Scientific data and clinical observations indicate that polyoxymethylene is a promising material that bridges gaps in dental therapeutic options. While survival time may be limited due to wear, POM might be a favorable option for application in semi-permanent restorations.