bluuebunny/crossref_metadata_2025 huggingface dataset:
Can a novel opioid-free protocol following total knee arthroplasty prevent chronic opioid addiction? A follow-up study of 386 patients.
Authors: Wickline Andrew , Corrado Kayleigh
Published: September 2023

Background:

Studies have shown that there is an approximately 8.2% risk of chronic addiction after total knee arthroplasty (TKA) using conventional methods to recover from surgery in patients who are opioid-naive (1). A previous study by the authors found that a novel multimodal protocol significantly reduced the use of postoperative TKA opioids in the first 90 days post-op (2). The present study sought to ascertain whether the protocol had persistent effects which led to a lower risk of chronic addiction than that which is currently published.

Methods:

All 386 patients from the previous study who underwent TKA were identified through a HIPPA-compliant portal and searched on the New York State Internet System for Tracking Over-Prescribing (NYS I-STOP) database. Patients who had received one or more opioid prescriptions in the 12 months preceding the I-STOP search were noted and then individually contacted to ascertain the reason for the prescription.

Results:

Overall, 88 patients received an opioid prescription within 12 months of searching I-STOP, 73 of which were opioid-naive. Of the opioid-naive patients, 10 were defined as chronic opioid users post-TKA, but only one patient named the TKA as the reason for using opioids. This study found that there was a 0.28% (1/356) chance for opioid-naive patients to become chronically addicted to opioids as a direct result of the TKA. The overall risk of becoming a chronic opioid user for any reason (including TKA) was 2.81% (10/356). The overall risk of an opioid-naive patient receiving at least one or more opioid prescriptions outside of the 90 day window after TKA for any reason was 20.5% (73/356).

Conclusions:

Following the previously published novel multimodal protocol led to a significant reduction in post-operative risk for converting to chronic opioid use in patients who were opioid-naive prior to surgery as directly related to the TKA. This study suggests that querying large databases for opioid use after TKA may not capture the actual reason for post-surgical opioid prescriptions and further study is warranted to determine the actual frequency with which TKA is responsible for chronic opioid use.
Apontamentos práticos para a implementação da Lei Geral de Proteção de Dados nas instituições
Authors: Angelo Edna da Silva
Published: September 2023

A Lei Geral de Proteção de Dados Pessoais, instituída pelo poder legislativo do Brasil, objetiva tutelar os direitos de proteção e privacidade de pessoas naturais. Entrar em conformidade tornou-se mais uma das tarefas a serem cumpridas por organizações brasileiras, sejam elas do setor público ou privado. O livro intitulado “LGPD: manual de conformidade” tem o objetivo de apresentar um passo a passo sobre a garantia da proteção de dados pessoais, com base na literatura nacional e internacional e considerando casos reais. Apresenta cinco passos essenciais que possibilitam a adequação das instituições às disposições legais: análise de gaps/lacunas; plano de ação de adequação; governança de dados; mapeamento de processos de tratamento de dados pessoais; e medidas técnicas e administrativas. É um livro objetivo e preciso na mensagem transmitida, com destaque a sua didática e o seu foco direcionado à prática profissional para a adequação das instituições.
Pengaruh Kecerdasan dan Literasi Keuangan Terhadap Ketahanan Keuangan UMKM di Sentra Wisata Kuliner Jambangan Surabaya
Authors: Alinda Dwi Jofanka  , Shofiatus Sa’diyah  , Farah Estianingtyas  , Maria Yovita R.Pandin
Published: September 2023

The purpose of this study was to determine the effect of intelligence and financial literacy on the financial resilience of Micro, Small and Medium Enterprises in the Jambangan Culinary Tourism Center, Surabaya. This research was conducted on the type of business, namely in the culinary or trading business sector with a sample size of 30 micro, small and medium enterprises. In this study using a quantitative approach method. This study uses multiple linear regression techniques for hypothesis analysis. The results of the study show that intelligence and financial literacy have a high impact of 57,1% on the financial resilience of Micro, Small and Medium Enterprises in the Jambangan Culinary Tourism Center, Surabaya.
Metode Perekrutan Karyawan UKM Melalui Wawancara dengan Pendekatan Visi, Misi, Dan Nilai Perusahaan
Authors: Utama Adiguna Sasama Wahyu , Widigdyo Anang , Widayani Anna
Published: September 2023

SMEs or Micro, Small and Medium Enterprises play a very important role for the Indonesian economy. In the Indonesian economy, SMEs are the business group with the largest percentage. However, of the much assistance and attention provided by the government to SMEs, very little has been discussed regarding the Human Resources (HR) involved as employees in SMEs. so that SMEs can have a competitive advantage over their larger competitors, SMEs need to be involved in effective and efficient HR management practices, one of which is in terms of recruiting employees. One method of recruiting employees that is simple and can be applied easily is an interview. However, in conducting interviews, SME actors cannot ask questions without a clear framework because it will waste time and energy. Interview questions can be developed based on the three categories that most influence employee engagement, namely organizational factors, job factors, and individual factors.
Pengaruh Kepemimpinan Transformational Terhadap Organizational Citizenship Behavior Karyawan Pada Perusahaan Tekstil di Jakarta Timur
Authors: Aziza Pretty Failasufa
Published: September 2023

Penelitian ini menggunakan pendekatan kuantitatif. Data dikumpulkan melalui kuesioner dan wawancara mendalam. Responden dalam penelitian ini adalah karyawan swasta pada perusahaan tekstil di Jakarta. Penelitian ini menggunakan Transformational Leadership Behaviour Inventory (TLI) untuk mengukur kepemimpinan transformational dan OCB scale dengan 5 dimensi utama dari Podsakoff untuk mengukur OCB. Jumlah responden dalam penelitian ini adalah 221 dari beberapa jumlah karyawan pada perusahaan tekstil di Jakarta. Hasil dari penelitian ini menunjukkan bahwa kepemimpinan transformational berpengaruh signifikan terhadap organizational citizenship behavior. Namun kepemimpinan transformational secara parsial tidak berpengaruh signifikan terhadap organizational citizenship behavior. Hal ini disebabkan oleh: (1) terdapat faktor lain yang lebih mempengaruhi organizational citizenship behavior salah satunya adalah kepemimpinan transaksional karena kepemimpinan transaksional mempertimbangkan perilaku extra role maupun in role  para bawahannya, hal tersebut menyebabkan bawahan akan menunjukkan kinerja OCB-nya, (2) perlu mempertimbangkan supaya kecerdasan emosional menjadi variabel mediasi antara kepemimpinan transformational dengan organizational citizenship behavior sehingga pengaruh kepemimpinan transformational terhadap OCB dapat dirasakan secara tidak langsung melalui kecerdasan emosional.
Innovative Teaching Methods and Materials Design in College English Education
Authors: Miao Lizhu
Published: September 2023

In the context of increasing globalization and digitalization, innovations in English teaching methods and materials design play a crucial role in meeting students' needs, improving learning outcomes, and adapting to social and technological developments. This article provides a comprehensive overview of these innovative approaches and designs in university English education, revealing the characteristics and limitations of existing teaching methods and materials, and analyzing them in light of students' and teachers' attitudes and feedback. The article further explores diversified teaching strategies and technology-driven teaching methods, describing their effectiveness and feedback.
A Study on the Design and Implementation Plan of Computer Network Architecture in Education and Teaching
Authors: Shu Lei , Bi Cheng
Published: September 2023

With the rapid development of information technology, computer network has penetrated all aspects of education and teaching and become an indispensable infrastructure in modern teaching. On the one hand, the reasonable design and effective implementation of network architecture provide teachers with rich and diverse teaching means and platforms, greatly widening the teaching space and improving teaching efficiency; on the other hand, it also provides students with a more open and independent learning environment, making the time and space for learning greatly extended. However, it is an extremely challenging problem to design and implement a scientific and reasonable, safe, and reliable education and teaching computer network architecture to meet the growing diversified educational needs. Based on this, the article discusses in depth the design and implementation plan of computer network architecture in education and teaching, to provide some useful references and ideas for the construction of education informatization.
A Study on the Strategies for Improving the Teaching Design Ability of Young College English Teachers under the Background of Curriculum Ideological and Political Education
Authors: Ye Yao
Published: September 2023

This paper takes a teaching plan winning the grand prize in a competition in 2022 as a case, focuses on the important elements of designing a teaching plan, explores strategies for improving the teaching design ability under the background of Curriculum Ideological and Political Education, and aims to provide a reference path for young college English teachers to improve their teaching design ability.
Exploring the Innovative Mode of Engineering Cost Education in the Context of Double High
Authors: Liu Yamei
Published: September 2023

In the current double-high context, the traditional education model cannot meet the needs of the industry and students, so there is a need to explore innovative models. This includes promoting internships, practical training, hands-on teaching, and innovating curriculum and teaching methods. Through these innovative initiatives, engineering cost education can enhance students' practical skills, teamwork, and problem-solving abilities to meet the needs of industry development. At the same time, the introduction of information technology, diversified teaching methods, and personalized teaching can improve teaching effectiveness and students' learning experience. Such innovative exploration can help cultivate high-quality engineering cost talents and promote a close match between education and industry needs.
Le rôle des tribunaux ontariens dans la reconnaissance des traits socioreligieux amish
Authors: Legault-Laberge Raphaël Mathieu
Published: September 2023

Les amish sont présents dans le sud ontarien depuis 1822. Ce groupe religieux minoritaire manifeste certains traits socioreligieux uniques qui font partie de leur normativité (Ordnung), tels que l’utilisation des chevaux pour leurs déplacements et leurs travaux agricoles et la communalisation intergénérationnelle des espaces de vie familiaux. Ces mêmes caractéristiques ont surgi comme éléments centraux de certaines décisions des tribunaux ontariens. Ces tribunaux ont-ils contribué à la reconnaissance des spécificités socioreligieuses et normatives des amish ? Si oui, à quel niveau et dans quelle mesure ? L’hypothèse avancée dans le cadre de cette étude postule que les tribunaux ont influencé positivement la reconnaissance des traits socioreligieux amish, et ce, à l’échelle locale. Les deux cas considérés afin d’étayer cette hypothèse (Mornington (Township) v. Kuepfer et Stoll v. Kawartha Lakes (City) Committee of Adjustment) concernent le droit municipal. Dans le premier cas, les amish ont obtenu le droit de garder des chevaux dans une municipalité où un règlement l’interdisait formellement. Dans le second cas, les amish ont obtenu le droit de construire une seconde résidence sur un terrain agricole où cela n’était pas permis. Dans les deux cas considérés, les tribunaux ontariens ont reconnu la liberté de religion des amish, jouant un rôle dans la reconnaissance de leurs traits socioreligieux.
Rencontrer la mer : l’expérience vécue d’une expédition en voilier sur le Saint-Laurent en contexte d’intervention sociale
Authors: Gendreau Robert Henri-Bastien , Genest-Dufault Sacha
Published: September 2023

Bien qu’un nombre grandissant d’études soulignent les bienfaits de l’interaction avec la nature (Institut de cardiologie de Montréal, 2021), rares sont celles qui se penchent spécifiquement sur le rôle des environnements marins dans le cadre des pratiques centrées sur la nature et l’aventure. Or, ces espaces qu’il convient d’appeler les « environnements bleus » possèdent des caractéristiques qui leur sont propres et sont reconnus notamment pour leurs effets bénéfiques sur la santé physiologique et psychologique (White et al., 2020). Il existe à travers le monde différents programmes qui, par l’entremise d’un séjour en mer à bord d’un voilier, ont pour but de soutenir des personnes et des groupes vivant diverses difficultés (Schijf et al., 2017). Les pratiques d’intervention misant sur la navigation à voile offrent ainsi une singulière occasion d’immersion dans un environnement marin. Cet article présente des résultats de recherche et une réflexion quant à ce phénomène à ce jour peu étudié sous l’angle du travail social. L’article s’appuie sur les résultats préliminaires d’un mémoire de maitrise en travail social en cours de réalisation à l’Université du Québec à Rimouski qui vise, par une approche phénoménologique, à mieux comprendre l’expérience vécue par les personnes intervenantes et participantes lors d’une expédition en voilier sur le Saint-Laurent en contexte d’intervention sociale.
Direitos humanos e bioética
Authors: Gabriel Fábio Antônio , Tedesco Anderson Luiz
Published: September 2023

Este artigo discute articulações entre direitos humanos e bioética, parte do pressuposto de que todos são iguais perante a lei, e de que não existem diferenças legais entre os cidadãos; mas para além disso, os direitos humanos se constituem em fundamentos éticos, que resultam em proteção da vida, da liberdade, da igualdade, da dignidade e do bem-estar social das pessoas. Desse contexto surge a problemática: Como constituir uma consciência bioética e as suas interfaces entre educação e bioética ambiental, em caminhos de responsabilidade ética nas relações humanas e planetárias? Trata-se de uma pesquisa bibliográfica, com abordagem qualitativa, em que se buscou subsídios teóricos e epistemológicos nas obras de David Wallace – Wells; Hans Jonas e Van Rensselaer Potter, entre outros. As constatações sinalizaram que os direitos humanos defendem princípios gerais, instituídos na Declaração Universal dos Direitos Humanos e em Constituições (democráticas), questões centrais acerca da dignidade humana; a bioética preceitua a relevância de atitudes práticas (éticas), inclusive no próprio exercício profissional e interdisciplinar, que assegurem o respeito às condições do viver humano e planetário. Por outro lado, a educação ambiental (re)introduz a capacidade de reflexão sobre o princípio da responsabilidade das ações do ser humano. Conclui-se que a bioética é uma ponte entre o humano e as condições da existência no/do planeta e, acima de tudo, constituí uma educação da sabedoria (responsabilidade) para a sobrevivência da mãe-terra (Gaia).
A “casa” em tempos de pandemia
Authors: PIETERZACK CRISTIANE , ROSANELI CAROLINE
Published: September 2023

Nesta época a qual podemos, sem exagero, definir como “época pandêmica” somos levados a refletir, entre outros temas, sobre o sentido do “habitar”. O “habitar”, atualmente, se transformou em uma questão que nos interpela a pensar um “reinício” a partir da descoberta de sentidos prioritários para a existência humana. O objetivo deste artigo é trazer à tona o sentido prioritário do “habitar”, uma vez que tal sentido se apresenta revelador, não somente da tragédia que atravessamos recentemente e da qual ainda não temos certeza alguma de que nos livramos, mas também, e sobretudo, da complexidade das interrelações que nos constituem seres éticos. A metáfora da “casa” servirá como chave de leitura, seja do pensamento aristotélico quanto do pensamento levinasiano, no que diz respeito ao habitar a partir de uma filosofia prática e de uma ética-metafísica.
escuta como método e os pobres/oprimidos como sujeitos
Authors: Andrade Martins Alexandre
Published: September 2023

Considerando desafios em saúde global, este texto busca compreender o impacto do global no local a partir de uma proposta de bioética global não universal, mas plural. As ações em saúde global são dominadas por uma perspectiva ocidentalizada de assistência à saúde em realidades locais que parte de um modelo de cima para baixo. Este artigo analisa essa perspectiva por meio de aspectos essenciais das iniciativas em saúde global – métodos, atores principais, financiamento e mentalidade – que levam a perceber a sua limitação aos fundamentar modos de operar em saúde global e, ao mesmo tempo, contraditoriamente contribuem para os mesmos problemas que afirma enfrentar ao responder necessidades imediatas em saúde de populações empobrecidas. Seguindo a identificação dessa limitação, o artigo argumenta por uma perspectiva que parta do local, das experiências sentidas na realidade concreta das pessoas, para, então, avançar para o global, que será um global plural e inclusivo em vista de construir colaboração. Assim, não há um global epistemológico e normativo da prática como é a perspectiva ocidental dominante, mas um global plural que é universal no proceder – do local para o global – mas plural no compreender e no enfrentar os desafios em saúde global, sem uma epistemologia dominante. Dessa forma, um ethos de colaboração é desenvolvido a partir da escuta e do aprendizado mútuo que ocorrem onde o desafio é experienciado. Por fim, o autor apresenta a escuta como primeiro movimento em saúde global fundamentado em uma bioética global plural e inclusiva, em um constante desenvolvimento epistemológico com impacto ético.
Mokslinis tomistinės metafizikos pobūdis
Authors: Plėšnys Albinas
Published: September 2023

Nuo Aristotelio laikų metafizika buvo laikoma mokslu, tačiau Šviečiamajame amžiuje moksline metafizikos verte buvo suabejota. Šiuolaikinėje mokslo filosofijoje metafizika arba laikoma beprasme, arba nepriklausančia mokslui. Griežčiausius mokslo apibrėžimus pateikė R. Carnapas ir K. R. Popperis. Pasak R. Carnapo, moksliniai teiginiai turi būti prasmingi, juos turi būti galima patikrinti, o moksliniai terminai privalo turėti reikšmes. Svarbiu mokslinės teorijos bruožu laikysime prasmės ir reikšmingumo reikalavi mą. K. R. Popperis mano, jog teorija yra mokslinė tik tada, kai ji turi tokią loginę struktūrą, kad, teorijos teiginiams nepasitvirtinus, jos turėtume atsisakyti. Tomistinė metafizika atitinka prasmės ir reikšmingumo reikalavimus. Šv. Tomas Akvinietis žodžio reikšmę apibūdina trimis būdais. Pirma, žodžio reikšmė yra tai, ką protas siekia išreikšti žodžiais, o apibrėžiamų dalykų reikšmė yra nusakoma apibrėžimu. Antra, kartais žodžio reikšmė yra nurodymas į objektą. Trečia, žodžio reikšmė yra žodžio vartojimas kalboje. Pasak Tomo Akviniečio, pastarasis reikšmės nustatymo būdas yra svarbiausias metafizikoje, nes daugelis jos sąvokų neturi giminės, todėl negali būti apibrėžtos. Straipsnyje siekiama parodyti, kad tomistinė metafizika atitinka visus mokslinei teorijai keliamus reikalavimus, nes joje yra išsami prasmės teorija ir jos teiginiams taikomi tiesos kriterijai.
Atrium on the university campus
Authors: Baklyskaia Larisa Evgen'evna , Chukmareva Elizaveta Andreevna , Fisheva Natal'ya Olegovna
Published: September 2023

The article discusses atrium spaces in the university environment. The subject of the study is the architectural and design organization of informal learning spaces (open atriums). The relevance of the research is determined by the importance of the practical implementation of the ideas and principles of using atrium spaces in the design of the learning environment, including when developing a detailed plan for the creation of an intercollegiate campus on the basis of the Pacific National University (PNU) in the city of Khabarovsk. Campus concepts involve a large number of open educational spaces and transformable classrooms. Particular attention is paid to the study of students' preferences in determining the key characteristics of spaces for informal learning that determine their use. The novelty of the research may be the identification of design features of informal learning spaces (open atriums) and consideration of techniques for shaping environmental objects of this type from general design principles to the development of subject content. The case study was conducted at the Department of Architectural Environment Design of Pacific National University. Mixed research methods were used, including observation, visual analysis, questionnaires and interviews, as well as testing of theoretical conclusions in diploma and course projects of students of PNU. The main results of the work are the basis for further research and can be used to develop future strategies for designing informal learning spaces.
Beta-induced Alfvén eigenmodes with frequency chirping driven by energetic ions in the HL-2A Tokamak
Authors: Hou Yu-Mei , Chen Wei , Zou Yun-Peng , Yu Li-Ming , Shi Zhong-Bing , Duan Xu-Ru ,   Southwestern Institute of Physics, Chengdu 610041, China
Published: September 2023

The beta-induced Alfvén eigenmodes (BAEs) with frequency chirping, observed in the HL-2A Tokamak, are analysed by a MHD-kinetic hybrid code MEGA. Realistic parameters are applied to the code, such as equilibrium, electron density and temperature, ion temperature, which is different from the kinetic Berk-Breizman theory. The BAEs are observed by Mirnov probes and soft X-ray arrays. Toroidal and porloidal mode number are confirmed to be n/m = 2/3 by using the phase shift method with toroidal filtered Mirnov signal arrays. And the soft X-ray arrays’ signal shows that BAEs are located at the core of the plasma and they have a relatively broad mode structure. The BAEs with up- and down-chirping are reproduced with MEGA code. The simulation results of mode structure accord well with experimental observations. Compared with up-chirping BAEs, the down-chirping BAEs are excited with higher plasma parameters and beta value, thus the energetic ion distribution in pitch angle has a broader width, and the beta value of energetic ions in the core of plasma and diffusion value are higher in the down-chirping simulation. The simulation results show that the phase space distribution of energetic ions affects the wave chirping direction. The energetic ions parallel to the magnetic field drive the up-chirping behavior. When the down-chirping behavior dominates, the density of energetic ions perpendicular to the magnetic field increases significantly. It shows that the down-chirping BAEs require higher beta and energetic ion density, which is consistent with the previous simulation result.
Introduction
Authors: Panieri Giuliana , Stiller-Reeve Mathew , Bertolotto Bianc Giuliano
Published: September 2023

An introduction to the 5 interdisciplinary lesson plans about the ocean and connecting with it via the senses that make up this booklet. The booklet was developed as part of the Advancing Knowledge about Methane in the Arctic (AKMA) Project, which is also briefly presented here.
生活从难闻
Authors: Stiller-Reeve Mathew , Rosnes Erling , Eiliertsen Mari , Ramalho Sofia , Poddevin Victor , Panieri Giuliana , Bertolotto Bianc Giuliano
Published: September 2023

重点：

要了解硫化氢表明在深海底部有生命。

学习目标：

通过这个活动，我们创造了一种类似于有机物腐烂产生的硫化氢的讨厌的气味。我们以这种

气味为基 础，讨论/讲授来自深海海底的有趣的生命、动物和食物网。

键词：

深海，硫化氢，化能合成，线虫动物门，管虫，食物网。
冷泉之行
Authors: Mohadjer Solmaz , Aune Vibeke , Oddone Davide , Panieri Giuliana , Bertolotto Bianc Giuliano
Published: September 2023

重点：

冷泉在哪里, 在冷泉会发生什么，以及科学家如何研究它们。

学习目标：本课结束后，学生应该能够：

通过观察和描述科学地图，将不同的数据集联系起来

 

区分二氧化碳和甲烷气体

澄清对温室气体的错误认识

解释什么是冷泉，为什么大多数气体/甲烷水合物发生在大陆边缘

描述科学家用来定位和研究甲烷/天然气水合物的一些方法

前提

在本课之前，学生应该熟悉了解地图、分子结构和结合，以及温室效应和气体。

键词：

北冰洋, 甲烷, 二氧化碳, 气体水合物, 冷泉, 温室气体
Detection of True Hybrids in Pearl Millet Cross Combinations by Employing SSR Molecular Markers
Authors: Patel Vinod , Tripathi M. K. , Shrivastava Rakesh K. , Tiwari Sushma , Chauhan Shailja , Tripathi Niraj , Pandya R. K. , Parihar Prerana , Khandelwal Vikas , Satyavathi C. Tara
Published: September 2023

Pearl millet (Pennisetum glaucum L. R. Br.), a crucial staple food and significant cereal crop, is gaining prominence due to its versatile applications as feed, food, and fodder. Heterosis of this crop has been extensively harnessed to increase productivity. Hybrid variants exhibit superior grain and stover yields compared to open-pollinated varieties.Top of Form The primary aim of this investigation was to evaluate and confirm authentic hybrids within three resultant F1 progenies. The assessment of parents and F1 hybrids was carried out during the Kharif 2021for the purpose of accurate discrimination and rapid verification of true hybrids by employing 20 SSR molecular markers. The experimental materials consisted of three distinct cytoplasmic male sterile (CMS) lines including ICMA 843-22, ICMA 04999, and ICMA 02333, used as female parents along with three fertility restorers, viz., ICMR 01004, ICMR 20233, and ICMR 20342, were utilized as male parents. The analysis of SSR profiles was based on distinctive banding patterns, resulting in unique profiles for the hybrids. The amplified fragment sizes ranged between 90 to 300 base pairs (bp), effectively enabling the differentiation of authentic hybrids. Within the specific crosses, the percentage of polymorphism was determined 75% for the cross ICMA 843-22 × ICMR 01004, 80% for the cross combination  ICMA 04999 × ICMR 20233, and 75% for the cross ICMA 02333 × ICMR 20342. The true hybrids were calculated using hybrid purity percentage formula using heterozygous banding patten among total plants evaluated. Among a total of 100 F1 plants, 85, 86, and 88 plants were accurately identified as true hybrids in the respective crosses i.e., ICMA 843-22 × ICMR 01004, ICMA 04999 × ICMR 20233, and ICMA 02333 × ICMR 20342. The identified markers hold significant potential for applications such as hybridity test, genetic purity assessments, diverse germplasm identification, and DNA fingerprinting endeavors in future.
Standardization of Softwood Grafting in Avocado (Persea americana Mill.) var. TKD1
Authors: Subash B. , Muthuramalingam S. , Balakumbahan R. , Venkatesan K. , Anitha T.
Published: September 2023

In recent years, Hass avocados (Persea americana Mill.) have become more widely cultivated in Colombia. One of the difficulties facing the nation is boosting orchard output by ensuring graft plants have the best agronomic, genetic, and phytosanitary criteria. In this study, the growth and development of avocado rootstocks derived from seeds of various weight ranges will be monitored for 90 days. Four weights of avocado seeds (S1, S2, S3, S4) (30–40 g, 40–50 g, 50–60 g, and 60-70 g) and four scion maturity of (D1, D2, D3, D4) (60 days old, 70 days old, 80 days old, 90 days old were used as treatments in a factorial completely randomized experimental design. The outcome showed that the best germination rate of 75% for S4 and the highest survival percentage (94.98%) for S4D4. After 90th DAG the maximum number of new shoots per plant (5.75), number of leaves/plants (18.15), leaf area (20.83 cm2), and carbohydrate content (6.57%) were reported. Based on the results of the experiment, it was determined that the optimum method for propagating avocados was softwood grafting using 60–70 g seed size (rootstock) and 90-day-old scion. These plants had better vigor and faster germination rates, all of which could reduce the length of time spent in the nursery while still ensuring the quality of the material, which is influenced by improved seedling growth.
Study the Biology of Common Castor Butterfly, Ariadne merione merione (Cramer) (Nymphalidae: Lepidoptera)
Authors: Dwarka  , Panday Anand Kumar , Vishwakarma Deepali , Thakur Kiran
Published: September 2023

A laboratory experiment was conducted at the PC Unit Sesame & Niger, Department of Entomology, JNKVV, Jabalpur on biology of spiny castor caterpillar, Ariadne merione merione (Cramer) on castor. Considerable variation in larval period on castor plants was observed, with the shortest of 27.41(max.) and 25.80 (min.) days being when reared on castor leaves. Generally, females length longer than males on all the castor plants. The average developmental period of 1st, 2nd, 3rd, 4th and 5th larvae were 70.92±4.89, 109.22±1.81, 134.37±1.87, 147.87±4.12 and 176.82±5.67 hours, respectively. The pupa length and width ranged from 18.79±0.74 mm and 5.62±0.11 mm, respectively. The periods of pre-oviposition, oviposition and post-oviposition in hours sequencely, 59.62±6.17, 121.42±2.42 and 61.69±3.20, respectively.
Investigation of Recycled Plastic Waste into Bricks for the Construction of Housing Projects in Ghana
Authors: Thomas Akyen , Baah Christopher Kwesi , Odonkoh Jonathan , Offei Samuel Wilberforce
Published: September 2023

Alternative materials are now being used for the construction of various projects in Ghana due to the expansion of infrastructure in the country. The quantity of materials needed to build infrastructure presents a significant opportunity to reuse some of the waste products. It has become possible to investigate the recycling of plastic waste into the construction of bricks due to the substantial discrepancy between the supply and demand of traditional building materials. In this study, an effort was made to recycle a sizable amount of HDPE waste gathered from markets, shopping centers, landfills, and supermarkets for utilization of bricks for housing projects. To determine the efficacy and durability of the bricks made from recycled plastic waste for various uses in civil engineering projects, several experimental tests including the compressive strength test, split tensile test, and water absorption tests were conducted. The mix ratios for the plastic bricks for compressive and tensile strength are 1:3, 1:4, and 1:5.5, respectively, while their water absorption mix ratios are 1:2, 1:3, and 1:4. The experimental findings demonstrated that the bricks produced had good compressive strength, tensile strength and low water absorption rates. Additionally, it was observed that the manufactured bricks are lightweight, have a smooth surface and fine edges, and can be an excellent substitute for clay and conventional concrete blocks, which have been used for decades to build housing projects in the country.
Variance of US Hospital Characteristics by Safety-Net Definition
Authors: McNeill Elizabeth , Cronin Cory , Puro Neeraj , Franz Berkeley , Silver Diana , Chang Ji
Published: September 2023

This cross-sectional study examines whether characteristics of hospitals differ across 5 frequently used safety-net hospital definitions using 2020 data.
Antidepressant Use and Mortality Among Patients With Hepatocellular Carcinoma
Authors: Huang Kuan-Lun , Chen Yi-Lung , Stewart Robert , Chen Vincent Chin-Hung
Published: September 2023

Importance

Liver cancer, primarily hepatocellular carcinoma (HCC), is the third leading cause of cancer deaths worldwide. Although some studies have proposed that antidepressants may have apoptotic effects on cancer, no study has examined the association between antidepressant use and HCC prognosis.

Objective

To investigate the association between antidepressant use and mortality risk in patients with HCC.

Design, Setting, and Participants

This population-based cohort study analyzed Taiwan’s National Health Insurance Research Database, which covers 99% of Taiwan’s population and includes comprehensive medical information. Patients with a new diagnosis of HCC between 1999 and 2017 were identified. Analysis took place in June 2023.

Main Outcomes and Measures

All patients with HCC were followed up until 2018 to measure overall and cancer-specific mortality. To examine whether the timing of antidepressant use influenced the association with mortality, antidepressant use was examined before and after HCC diagnosis. Cox proportional hazards regression was performed to estimate hazard ratios (HRs) and the 95% CIs for the association between antidepressant use and overall mortality and cancer-specific mortality.

Results

The study cohort comprised 308 938 participants, primarily consisting of older individuals (131 991 [42.7%] were aged ≥65 years) with a higher proportion of male individuals (202 589 [65.6%]). Antidepressant use before the diagnosis of HCC was not associated with lower risks of overall mortality (adjusted HR, 1.10; 95% CI, 1.08-1.12) and cancer-specific mortality (adjusted HR, 1.06; 95% CI, 0.96-1.17). However, antidepressant use after a diagnosis of HCC was associated with a lower risk of overall mortality (adjusted HR, 0.69; 95% CI, 0.68-0.70) and cancer-specific mortality (adjusted HR, 0.63; 95% CI, 0.59-0.68). The observed associations were consistent across subgroups with different antidepressant classes and comorbidities, including hepatitis B virus or hepatitis C virus infection, liver cirrhosis, and alcohol use disorders.

Conclusions and Relevance

Based on this nationwide cohort study, postdiagnosis antidepressant use may be associated with lower mortality in patients with HCC. Further randomized clinical trial evaluation should be considered.
Stress as a Risk Factor for Mental Disorders in a Gendered Environment
Authors: Mazure Carolyn M. , Husky Mathilde M. , Pietrzak Robert H.
Published: September 2023

This Viewpoint discusses the value of assessing specific stressors that may vary by gender when assessing mental health to better inform our knowledge of stress effects and aid in developing better targeted, gender-informed prevention and treatment efforts in psychiatry.
Using Telehealth to Improve Access to Trauma Care Among Injured Rural Patients in the US
Authors: Hashmi Zain G. , Wallace Eric L. , Kerby Jeffrey D.
Published: September 2023

This Viewpoint discusses the use of telehealth as an alternative approach to expand access to critical resources for injured US patients arriving at rural hospitals.
Environmental Impact Assessment of Reusable and Disposable Surgical Head Covers
Authors: Cohen Eva S. , Djufri Sarah , Bons Selma , Knoppert Mike. R. , Hehenkamp Wouter J. K. , Kouwenberg Lisanne H. J. A. , Sperna Weiland Nicolaas H.
Published: September 2023

This life cycle assessment compares the environmental footprint of reusable surgical head covers with single-use disposable surgical head covers.
Hyperthermic Intraperitoneal Chemotherapy After Interval Cytoreductive Surgery for Patients With Advanced-Stage Ovarian Cancer Who Had Received Neoadjuvant Chemotherapy
Authors: Lee Jung-Yun , Lee Yong Jae , Son Joo-Hyuk , Kim Sunghoon , Choi Min Chul , Suh Dong Hoon , Song Jae-Yun , Hong Dae Gy , Kim Mi Kyung , Kim Jae-Hoon , Chang Suk-Joon
Published: September 2023

Importance

Hyperthermic intraperitoneal chemotherapy (HIPEC) followed by interval cytoreductive surgery (ICS) has shown survival benefits for patients with advanced-stage ovarian cancer. However, there is still a lack of consensus regarding the integration of HIPEC into clinical practice.

Objective

To evaluate the safety and effectiveness of ICS with HIPEC compared with ICS alone in clinical practice for patients with advanced-stage ovarian cancer.

Design, Setting, and Participants

This prospective, multicenter, comparative effectiveness cohort study enrolled 205 patients with stage III or IV ovarian cancer who had received at least 3 cycles of neoadjuvant chemotherapy followed by ICS with HIPEC or ICS without HIPEC at 7 Korean Gynecologic Oncology Group institutions between September 1, 2017, and April 22, 2022. Nine patients were excluded because they did not meet the inclusion criteria.

Exposures

Neoadjuvant chemotherapy followed by ICS with HIPEC or ICS without HIPEC.

Main Outcomes and Measures

The primary end point was progression-free survival (PFS). Overall survival (OS) and the safety profile were the key secondary end points.

Results

This study included 196 patients (median age, 58.0 years [range, 38-82 years]), of whom 109 underwent ICS with HIPEC and 87 underwent ICS without HIPEC. The median duration of follow-up was 28.2 months (range, 3.5-58.6 months). Disease recurrence occurred in 128 patients (65.3%), and 30 patients (15.3%) died. Interval cytoreductive surgery with HIPEC was associated with a significant improvement in median PFS compared with ICS without HIPEC (22.9 months [95% CI, 3.5-58.6 months] vs 14.2 months [95% CI, 4.0-56.2 months]; P = .005) and median OS (not reached [95% CI, 3.5 months to not reached] vs 53.0 [95% CI, 4.6-56.2 months]; P = .002). The frequency of grade 3 or 4 postoperative complications was similar in both groups (ICS with HIPEC, 3 of 109 [2.8%] vs ICS without HIPEC, 3 of 87 [3.4%]; P > .99). Among patients with recurrence, the frequency of peritoneal recurrence was lower in the ICS with HIPEC group than in the ICS without HIPEC group (21 of 64 [32.8%] vs 41 of 64 [64.1%]; P = .001).

Conclusions and Relevance

This study suggests that ICS in conjunction with HIPEC was associated with longer PFS and OS than ICS without HIPEC for patients with advanced-stage ovarian cancer and was not associated with higher rates of postoperative complications. The lower rate of peritoneal recurrence after HIPEC may be associated with improved OS.
STAP‐2 negatively regulates BCR‐mediated B cell activation by recruiting tyrosine‐protein kinase CSK to LYN
Authors: Kashiwakura Jun‐ichi , Kawahara Shoya , Inagaki Iori , Inui Kyosuke , Saitoh Kodai , Kagohashi Kota , Sasaki Yuto , Kobayashi Fuki , Kitai Yuichi , Muromoto Ryuta , Oritani Kenji , Matsuda Tadashi
Published: September 2023

Although signal‐transducing adaptor protein‐2 (STAP‐2) acts in certain immune responses, its role in B cell receptor (BCR)‐mediated signals remains unknown. In this study, we have revealed that BCR‐mediated signals, cytokine production and antibody production were increased in STAP‐2 knockout (KO) mice compared with wild‐type (WT) mice. Phosphorylation of tyrosine‐protein kinase LYN Y508 was reduced in STAP‐2 KO B cells after BCR stimulation. Mechanistic analysis revealed that STAP‐2 directly binds to LYN, dependently of STAP‐2 Y250 phosphorylation by LYN. Furthermore, phosphorylation of STAP‐2 enhanced interactions between LYN and tyrosine‐protein kinase CSK, resulting in enhanced CSK‐mediated LYN Y508 phosphorylation. These results suggest that STAP‐2 is crucial for controlling BCR‐mediated signals and antibody production by enhanced CSK‐mediated feedback regulation of LYN.
The developmental characteristics of proactive and reactive aggression in late childhood: The effect of parental control
Authors: Guo Zhaoming , Hu Qian , Chen Jing , Hong Defan , Huang Yingying , Lv Jing , Xu Yuan , Zhang Ruiping , Jiang Suo
Published: September 2023

Previous research has confirmed that parental control is related to children's aggressive behavior. However, few studies have focused on proactive and reactive aggression to distinguish the different effects of parental psychological and behavioral control. Moreover, additional longitudinal evidence is needed to understand these links. In the current paper, a three‐wave longitudinal study was conducted to examine the developmental characteristics of proactive and reactive aggression and the role of parental control in China. A total of 484 4th‐ and 7th‐grade students participated at wave 1 (51.65% in 4th‐grade, Mage = 11.66 ± 1.52 years), 465 students (52.04% in 4th‐grade) at wave 2, and 447 children (51.90% in 4th‐grade) at wave 3. The results showed that: (1) Proactive aggression in late childhood remained stable overall, while reactive aggression displayed a clear upward trend. (2) In proactive aggression, boys and girls had a consistent developmental trend. The initial level of boys was higher than that of girls. In reactive aggression, the growth rate was inversely associated with their initial level and the initial level of boys in 7th‐grade was significantly higher than that of girls. (3) Both parental psychological and behavioral control positively predicted students’ reactive aggression in 4th‐ and 7th‐grade, whereas only parental behavioral control positively predicted proactive aggression in 7th‐grade students, with no gender differences.
Evaluation of computed tomography metal artifact and CyberKnife fiducial recognition for novel size fiducial markers
Authors: Nemoto Hikaru , Saito Masahide , Suzuki Toshihiro , Suzuki Hidekazu , Sano Naoki , Mochizuki Zennosuke , Mochizuki Koji , Ueda Koji , Komiyama Takafumi , Marino Kan , Aoki Shinichi , Oguri Mitsuhiko , Takahashi Hiroshi , Onishi Hiroshi
Published: September 2023

Purpose

This study aimed to compare fiducial markers used in CyberKnife treatment in terms of metal artifact intensity observed in CT images and fiducial recognition in the CyberKnife system affected by patient body thickness and type of marker.

Methods

Five markers, ACCULOC 0.9 mm × 3 mm, Ball type Gold Anchor (GA) 0.28 mm × 10 mm, 0.28 mm × 20 mm, and novel size GA 0.4 mm × 10 mm, 0.4 mm × 20 mm were evaluated. To evaluate metal artifacts of CT images, two types of CT images of water‐equivalent gels with each marker were acquired using Aquilion LB CT scanner, one applied SEMAR (SEMAR‐on) and the other did not apply this technique (SEMAR‐off). The evaluation metric of artifact intensity (MSD) which represents a variation of CT values were compared for each marker. Next, 5, 15, and 20 cm thickness of Tough Water (TW) was placed on the gel under the condition of overlapping the vertebral phantom in the Target Locating System, and the live image of each marker was acquired to compare fiducial recognition.

Results

The mean MSD of SEMAR‐off was 78.80, 74.50, 97.25, 83.29, and 149.64 HU for ACCULOC, GA0.28 mm × 10 mm, 20 mm, and 0.40 mm × 10 mm, 20 mm, respectively. In the same manner, that of SEMAR‐on was 23.52, 20.26, 26.76, 24.89, and 33.96 HU, respectively. Fiducial recognition decreased in the order of 5, 15, and 20 cm thickness, and GA 0.4 × 20 mm showed the best recognition at thickness of 20 cm TW.

Conclusions

We demonstrated the potential to reduce metal artifacts in the CT image to the same level for all the markers we evaluated by applying SEMAR. Additionally, the fiducial recognition of each marker may vary depending on the thickness of the patient's body. Particularly, we showed that GA 0.40 × 20 mm may have more optimal recognition for CyberKnife treatment in cases of high bodily thickness in comparison to the other markers.
Shallow kinetics induced by a metronome (SKIM): A novel contactless respiratory motion management
Authors: Sohn James , Polizzi Mitchell , McDonagh Philip Reed , Guy Christopher , Datsang Rabten , Weiss Elisabeth , Kim Siyong
Published: September 2023

Objectives

As an alternative to conventional compression amidst the COVID‐19 pandemic, we developed a contactless motion management strategy. By increasing the patient's breathing rate to induce shallow breathing with the aid of a metronome, our hypothesis is that the motion magnitude of the target may be minimized without physical contact or compression.

Methods

Fourteen lung stereotactic body radiation therapy (SBRT) patients treated under fast shallow‐breathing (FSB) were selected for inclusion in this retrospective study. Our proposed method is called shallow kinetics induced by a metronome (SKIM). We induce FSB by setting the beats‐per‐minute (BPM) high (typically in the range of 50–60). This corresponded to a patient breathing rate of 25–30 (breathing) cycles per minute. The magnitude of target motion in 3D under SKIM was evaluated using 4DCT datasets. Comparison with free breathing (FB) 4DCT was also made for a subset for which FB data available.

Results

The overall effectiveness of SKIM was evaluated with 18 targets (14 patients). Direct comparison with FB was performed with 12 targets (10 patients). The vector norm mean ± SD value of motion magnitude under SKIM for 18 targets was 8.2 ± 4.1 mm. The mean ± SD metronome BPM was 54.9 ± 4.0 in this group. The vector norm means ± SD values of target motion for FB and SKIM in the 12 target sub‐group were 14.6 ± 8.5 mm and 9.3 ± 3.7 mm, respectively. The mean ± SD metronome BPM for this sub‐group was 56.3 ± 2.5.

Conclusion

Compared with FB, SKIM can significantly reduce respiratory motion magnitude of thoracic targets. The difference in maximum motion reduction in the overall vector norm, S‐I, and A‐P directions was significant (p = 0.033, 0.042, 0.011). Our proposed method can be an excellent practical alternative to conventional compression due to its flexibility and ease of implementation.
Laminin–Dynamic Bonds Enable Multifunctionality in a Biological 2D Network
Authors: Bhuvanesh Thanga , Nie Yan , Machatschek Rainhard , Ma Nan , Lendlein Andreas
Published: September 2023

A layer of laminins, assembled on a thin sheet of collagen type IV (Col‐IV) forms the backbone of the basal lamina, which controls biological processes such as embryogenesis, tissue homeostasis, and development. Here, the dynamic functions of laminin‐111 (Lam‐111) in ultrathin films at the air–water interface are investigated. It is shown that the 2D confinement induces polymerization and that expansion via adlayer formation occurs only with extended growth time. The highly robust self‐assembly enables the functionalization of surfaces with cross‐linked 2D Lam‐111 networks of defined thickness using little more than a beaker. The 2D laminin material also displays two dynamic functions required for the maintenance of tissues – the capability for self‐renewal and self‐healing. By assembling Lam‐111 2D networks at the surface of Col‐IV sheets, freestanding bilayers closely mimicking the basal lamina can be produced in vitro. There is a marked difference in miPSC spreading and adhesion force between Lam‐111 sheets assembled in the presence or absence of Col‐IV. These fundamental studies highlight the importance of dynamic functions, encoded into the molecular structure of the building blocks, for the assembly, maintenance, and functioning of the complex material systems found in natural tissues and can provide cues for the molecular design of resilient technical systems.
Hyperelastic, Robust, Fire‐Safe Multifunctional MXene Aerogels with Unprecedented Electromagnetic Interference Shielding Efficiency
Authors: Wang Hengrui , Jiang Yue , Ma Zhewen , Shi Yongqian , Zhu Yanjun , Huang Ruizhe , Feng Yuezhan , Wang Zubin , Hong Min , Gao Jiefeng , Tang Long‐Cheng , Song Pingan
Published: September 2023

MXene aerogels have shown great potential for many important functional applications, in particular electromagnetic interference (EMI) shielding. However, it has been a grand challenge to create mechanically hyperelastic, air‐stable, and durable MXene aerogels for enabling effective EMI protection at low concentrations due to the difficulties in achieving tailorable porous structures, excellent mechanical elasticity, and desired antioxidation capabilities of MXene in air. Here, a facile strategy for fabricating MXene composite aerogels by co‐assembling MXene and cellulose nanofibers during freeze‐drying followed by surface encapsulation with fire‐retardant thermoplastic polyurethane (TPU) is reported. Because of the maximum utilization of pore structures of MXene, and conductive loss enhanced by multiple internal reflections, as‐prepared aerogel with 3.14 wt% of MXene exhibits an exceptionally high EMI shielding effectiveness of 93.5 dB, and an ultra‐high MXene utilization efficiency of 2977.71 dB g g−1, tripling the values in previous works. Owing to the presence of multiple hydrogen bonding and the TPU elastomer, the aerogel exhibits a hyperelastic feature with additional strength, excellent stability, superior durability, and high fire safety. This study provides a facile strategy for creating multifunctional aerogels with great potential for applications in EMI protection, wearable devices, thermal management, pressure sensing, and intelligent fire monitoring.