bluuebunny/crossref_metadata_2025 huggingface dataset:
Gestion durable des mangroves du complexe lagunaire de Grand-Lahou (Côte d’Ivoire) dans un contexte de pressions anthropiques
Authors: Egnankou Mathieu Wadja , Gnagbo Anthelme , Pagny Junior Placide Franck , Tiebre Marie-Solange
Published: June 2023

En Côte d’Ivoire, les mangroves sont réduites à une zone très restreinte le long du littoral et menacées par des activités anthropiques exponentielles sur la frange côtière. Cette étude s’est déroulée dans les localités de Grand-Lahou, Nzida, Braffédon, Ebonou, Adiadon et Groguida. L’objectif a été faire l’état des lieux puis proposer des mesures de gestion durable des mangroves de la zone d’étude. Pour cela, des groupes de gestionnaires et des personnes riveraines des mangroves ont été interrogés en utilisant une méthode d’enquête semi-structurée afin de connaitre les pressions anthropiques et cartographier les zones propices à la restauration. Les usages faits des mangroves ont été énumérés, des fréquences de citation et la valeur d’usage ont été calculés et des traitements cartographiques ont été effectués. Les résultats révèlent que la recherche du bois de Rhizophora racemosa et la pêche demeurent les activités les plus exercées dans les mangroves. Corrélativement à ces pressions, les pêcheurs ont mentionné une baisse des produits de pêche. Pour réhabiliter l’écosystème mangrove puis rétablir le stock halieutique, des sites ont été identifiés pour des opérations de reboisement et de renforcement de la mangrove. Ce sont des sites près des îles de Braffédon, Ahonzon ; entre Cap Lahou et le village de Noumouzou et dans les villages de Lègrèko et Groguida. La présente étude permettra d’avoir une base de données solides afin à la préservation durable des écosystèmes de mangroves.

In Côte d'Ivoire, mangroves are reduced to a very small area along the coast and threatened by exponential anthropic activities on the coastal fringe. This study took place in Grand-Lahou, Nzida, Braffedon, Ebonou, Adiadon and Groguida localities. The objective was to contribute to a sustainable management of mangroves in these areas. To do this, managers groups and people living along the mangroves were interviewed using a semi-structured survey method in order to know the anthropic pressures and to map the areas suitable for restoration. Mangrove uses were listed, citation frequencies and use values were calculated, and mapping treatments were performed. The results reveal that the search for Rhizophora racemosa wood and fishing remain the most important activities in the mangroves. Correlatively to these pressures, fishermen mentioned a decrease in fishing products. To rehabilitate the mangrove ecosystem and then restore the fishery stock, sites have been identified for reforestation and mangrove reinforcement operations. These are sites near Braffédon and Ahonzon tislands; between Cap Lahou and Noumouzou village; in Lègrèko and Groguida villages. This study will provide a solid data base for the sustainable preservation of mangrove ecosystems.
Effet de l’incorporation de la graine de pois d’angole (Cajanus cajan) dans l’alimentation sur les performances zootechniques du tilapia du Nil (Oreochromis niloticus) élevé en happa
Authors: Adjanke Amakoé , Palanga Koffi Kibalou , Taale Essodolom , Tchabi Atti , Tona Kokou
Published: June 2023

Dans le but d’évaluer l'effet de l’incorporation de graines de pois d’angole dans le régime du tilapia (Oreochromis niloticus), un essai d’alimentation de deux mois (Mai à juillet 2022) a été réalisé à l’unité d’expérimentations aquacoles de l’Institut Supérieur des Métiers de l’Aquaculture (ISMA) de l’Université de Kara au Togo. Ainsi, 360 alevins de poids moyen 2,84 ± 0,11g ont été répartis aléatoirement à la densité de 30 individus par happa installé dans des bacs, en triplicat. Ils ont été soumis à quatre aliments isoprotéiques granulés dosant 30% de protéines brutes ; AT (aliment commercial, Témoin) et trois aliments locaux (A0, A1, A2) contenant respectivement 0 ; 10 et 20% de graines de pois d’angole. A l’issue de l’essai, des résultats intéressants ont été obtenus. Les aliments testés n’ont pas causé de fortes mortalités pour l’espèce élevée puisque le taux de survie a varié de 91,11 à 98,89%. Les meilleurs résultats de croissance avec les régimes locaux ont été enregistrés chez les poissons nourris avec le régime A1 contenant 10% de la farine de pois d’angole (taux de conversion alimentaire, TCA = 1,99 ± 0,03 ; taux de croissance spécifique, TCS = 3,66 ± 0,05%/j et coefficient d’efficacité protéique, CEP = 1,97 ± 0,03). Au vu de ces considérations, ce régime se révèle prometteur pour des études ultérieures avec des traitements technologiques des ingrédients végétaux en vue de réduire l’effet des éventuels facteurs antinutritionnels sur la croissance des poissons.

A study on the growth performance of Oreochromis niloticus was carried out at the aquaculture experimentation unit of High Agricultural Trade Institute at the University of Kara in Togo with diets incorporating pigeon pea seed meal (Cajanus cajan L. Millsp.). Therefore, 360 mono-sex fry male of Nile tilapia (average weight: 2.84 ± 0.11 g) were distributed in 12 hapas placed in concrete tank (2.5 m3) at a density of 30 fishes per hapa. They were fed four isoprotein diets (30% PB) in triplicate including a commercial feed (AT) and three local feeds (A0, A1 and A2) containing respectively 0; 10 and 20% pigeon pea seed meal, for two months, from May to July 2022. At the end of this trial, encouraging results were obtained. Survival rate varied from 91% to 99%. The best growth performances with local feed were observed in the fish fed with A1 (Feed Conversion Ratio FCR = 1.99 ± 0.33; Protein Efficiency Ratio PER = 1.97 ± 0.03 and Standard Growth Rate SGR = 3.66 ± 0.05%/d). This diet shows promise for further studies with technological treatments of plant ingredients to improve diet quality on fish growth.
Cultural practices and use of pesticides on tomato (Solanum lycopersicum L.) market gardeners in Loumbila and Ouahigouya (Burkina Faso)
Authors: Oboulbiga Edwige Bahanla , Semde Zénabou , Kante-Traore Hyacinthe , Sempore Judith Nomwendé , Tiendrebeogo Stéphanie C. W. , Traore Korotimi , Tiendrebeogo Salamata , Sawadogo-Lingani Hagrétou , Dicko Mamoudou Hama , Parkouda Charles
Published: June 2023

The misuse of pesticides and their overdose on vegetables has an impact on people's health. The purpose of this study was to evaluate the cultivation and phytosanitary practices of tomato growers at the Loumbila and Ouahigouya vegetable growing sites. A survey on cultural and phytosanitary practices was carried out among 25 tomato producers at these two market gardening sites. Results show that 16% of producers use dams and 80% traditional wells as a source of water supply. The inputs used are mainly organic (cow's mouth, household waste) and chemical (NPK, urea) fertilizer. The frequency of use of chemical fertilizer is once a week at the Loumbila site and only once a month in the Ouahigouya site. All the producers surveyed used pesticides and 67% do not respect the deadlines for indicated on the packaging labels. A total of 16 pesticides (insecticides, fungicides) are used during tomato production. Cypermethrin and Lambda-cyhalothrin from the pyrethroid family and acetamiprid from the Neonicotinoid family were the most used by producers. Most of these pesticides are not intended for vegetable crops but rather for cotton crops. The pesticides used may remain in the tomato in significant amounts and pose a threat to consumers.
Développement et validation d’une méthode simple et rapide pour le dosage plasmatique de l’éfavirenz par chromatographie liquide haute performance
Authors: Thiombiano Cherileila , Yabre Moussa , Kam Sami Eric , Da Ollo , Koevi Nadège , Dorcas Paré , Dramane Kania , Traore Isidore Tiandiogo , Sandwidi Cynthia , Ouedraogo Abdoul-Salam , Fofana Souleymane , Sakira Abdoul Karim , Hien Herve , Some Touridomon Issa
Published: June 2023

L’éfavirenz est un inhibiteur sélectif non nucléosidique de la transcriptase inverse du virus de l’immunodéficience humaine de type 1 (VIH-1) se caractérisant par un index thérapeutique étroit et une forte variabilité inter-individuelle dans ses paramètres pharmacocinétiques. L’objectif de ce travail était de développer et valider une méthode rapide et simple de dosage plasmatique de l’éfavirenz par chromatographie liquide haute performance. Le développement a été effectué en utilisant une colonne C8 (100 x 4,6 mm, 5 μm) et une phase mobile constituée d’un mélange acétonitrile-eau, (55-45 v/v). Le débit et la longueur d’onde de détection étaient respectivement de 1 mL/min et 246 nm. Le temps de rétention de l’éfavirenz était de 6,2 minutes. Aucun étalon interne n’a été utilisé dans cette méthode. L’étude de validation a montré que la méthode mise au point était spécifique, linéaire, exacte et précise dans l’intervalle de concentration de 0,5 à 10 mg/L. La méthode ainsi développée et validée pourrait être utilisée pour déterminer la concentration plasmatique de l’éfavirenz dans le cadre d’un suivi thérapeutique pharmacologique des patients sous antirétroviraux.

Efavirenz is an anti-viral agent non-nucleoside reverse transcriptase inhibitor category used for the treatment of infections of human immune deficiency virus type-1 (HIV-1). It is characterized by a narrow therapeutic window and a high variability in its pharmacokinetic parameters. The objective of this work consisted of developing and validating a rapid and simple method for determination of efavirenz in human plasma using high performance liquid chromatography. The method was developed using a C8 column (100 x 4.6 mm, 5 μm) and a mobile phase consisting of acetonitrile and water 55/45, v/v. A flow rate of 1 mL/min and a wavelength of 246 nm was used. The retention time of efavirenz was 6.2 min. No internal standard was employed. The validation study showed that the developed method was selective, linear, accurate et precise over the concentration range of 0.5-10 mg/L. The developed and validated method could be used for the therapeutic and pharmacokinetic monitoring of efavirenz.
Multi-Stage optimization under uncertainty in reverse logistics operations: An industrial scenario
Authors: Das Prasun , Ghosh Sayantan
Published: June 2023

The major concern of reverse logistics operations involves reducing logistics costs, improving after sales service, waste disposal and providing good  quality service in today's green environment. Process optimization involving uncertainty under reverse logistics set-up is a major challenge. There is a  need to consider the dynamics of the real situation because of the variation of product/process characteristics to make the system more robust. A  comparative analysis and the need for multi-stage optimization are illustrated here based on a single stage optimization model after performing its  sensitivity analysis. Accordingly, a multi-stage optimization problem is formulated here to solve the cost optimization problem of charge mix under a  reverse logistics set-up of a foundry business and to deal with the uncertainties involved in a practical business scenario. The proposed framework can be  effectively implemented in a similar reverse logistics environment considering uncertainties of the process parameters/product characteristics.
Design of hybrid power system for COMSATS University Islamabad using homer pro software
Authors: Rashid Amir , Ehsan Muhammad , Rashid Javid
Published: June 2023

More than a billion people do not have access o electricity, so it is important to find ways to generate power close to where they live. Hybrid energy systems can be made and used to generate electricity for homes and businesses that are not connected to national or regional power grids. Hybrid  energy systems yield greater environmental and economic returns than stand-alone geothermal, solar, wind, or bigenerational systems. The goal of this  paper is to simulate a hybrid power system for COMSATS University in Islamabad that is both technically and economically feasible and plays a big part to  support clean energy production and safeguard the environment from toxic emissions. This paper provides a case study of COMSATS University Islamabad. The results showed that a hybrid system with a grid and a wind turbine that produced 1 MWh/yr was the best option. This study also provides  a cost summary of PV panels, batteries, diesel generators, capital value, replacement, operation and maintenance (OM), fuel cost, and salvage value in  dollars. In this study, a hybrid power system is designed that can provide us with a detailed analysis of power generation and consumption for the case  study.
Characterisation of cementitious composite materials based on calcined clay activated by silicate from rice husk ash and Ingessil silicate - activator: sodium hydroxide (NaOH)
Authors: Nkotto Ludovic Ivan Ntom , Kamgang Gaëlle Dounbissi , Nkengue Lionel Pierre , Kanda Judicaël Sandjong , Metekong Jordan Valdès Sontia
Published: June 2023

The ever-increasing cost of cement and its production of harmful carbone dioxide (CO2) has led development actors to continuously search for less  environmentally polluting and low-cost binders. Hence the interest in the valorisation of agricultural resources through the production of different  binders such as silicate for the elaboration of geopolymers at low manufacturing temperatures (<100 °C). In this study, Ingessil industrial silicate and rice  husk ash silicate were used as pozzolan raw materials to prepare geopolymers with sodium hydroxide as activator at a concentration of 12 M. Two types  of samples were developed: geopolymer mortars based on Ingessil silicate and geopolymer concretes based on Ingessil industrial silicate and rice husk  ash silicate. Sand and gravel were used as fine and coarse aggregates for the production of geopolymer concretes. They were represented 80% of the  mass of the geopolymer concretes according to the standards of elaboration.The porosity values obtained were of the order of 30%, i.e. water absorption  values of about 18%, apparent specific weight of about 5% and bulk density of 1.7%. The mechanical values of BGAC-RHA samples are higher  than those of BGAC-I. The physico-chemical properties of geopolymer mortars and concretes were similar.
Comparative bioactive compounds and antifungal potential evaluation of Mentha longifolia (L.) Hudson (Lamiaceae) extracts against plant pathogenic fungi
Authors: Ali Javid , Abbas Javed
Published: June 2023

The present study was design to evaluate the Mentha longifolia stem, flower and leaves infusion, decoction and hydroalcoholic extracts to determine the bioactive molecules and antifungal activities by zone of inhibition technique, Minimum inhibitory concentration (MIC) and minimum fungicidal  concentration (MFC) were assay by broth dilution technique and spore germination assay using Light Compound Microscope against plant pathogenic  fungi (Fusarium oxysporum, Aspergillus parasiticus, Rhizoctonia solani and Alternaria alternata). The Mentha longifolia phytochemicals were found in the  range flavonoids 3.8 - 2.4%, saponins were 5.6-3.4%, alkaloids 0.7-0.1% and total phenolic were 40-15 mg Gallic acid/g. The maximum zone of  inhibition 23±1 mm and 22±1 mm were found by hydroalcoholic leaves extract against Fusarium oxysporum and Aspergillus parasiticus respectively. The  MIC range of hydroalcoholic were 12.5-100 mg/mL, infusion were 25-100 mg/mL and decoction were 25-200 mg/mL. While MFC range of hydroalcoholic  were 25-200 mg/mL, infusion were 50- 200 mg/mL and decoction were 50-200 mg/mL. Spore germination assay reaveled that increse in the extract  concenetration decrese the spore germination. The results revealed that Mentha longifolia chemical composition might be build up as latent bio- fungicides against plant pathogenic fungi.
Universal programmable digital timer switch
Authors: Usman Ayinde M. , Rauf Alada S , Surajudeen-Bakinde Nazmat T , Oloyede Abdulkarim A , Otuoze Abdulrahaman O , Zakariyya Olayinka S.
Published: June 2023

Many electromechanical devices operation is dependent on timing concept. Different constituent parts are programmed to function on timestamp. In many home and industrial applications, timer switches form one of the major components. It is usually used for the operation of such devices. In this work, a simple but robust general-purpose universal programmable digital timer (UPDT) is proposed. The UPDT switch is a software-based timer with an interface that can be connected to a variety of devices to act as a switch for their operations. It is designed to perform a cyclic operation up to 100 times with a maximum switching time of 100 hours. The module presented in this work is capable of being used for the operation of a variety of devices such as utility load shedding device, water pump control, automatic poultry feed dispenser, automatic lawn watering system, among others.
Rameal Chipped Wood as a tool for soil temperature regulation
Authors: Kerrouche Ibrahim , , Ouahrani Ghania
Published: June 2023

The objective of our work is to study the influence of Rameal Chipped Wood (FCW) and cattle manure in the presence and absence of earthworms Octodrilus complanatus on the regulation of soil temperature of a sandy loam soil. The study station is located in a semi-arid zone (Constantine, Algeria). The results obtained show that the contribution of FCW cattle manure in the presence and absence of earthworms Octodrilus complanatus has a beneficial effect on soil temperature.
Effect of denaturing agents on a lectin isolated from marine sponge Axinella donnaniand its potential cytotoxic activity
Authors: Sadanandan Ratheesh , Rauf Arun. A.
Published: June 2023

Marine sponges are oldest metazoans which were found to have structural and biologically diverse lectins. A lectin isolated from marine sponge Axinella donnani (ADL) were evaluated for its stability against denaturing agents such as Urea, Thiourea and Guanidine hydrochloride. Urea and Thiourea decreases the stability of ADL in higher concentration (5 mM) while Guanidine hydrochloride does not show any activity. Finally, cyt otoxicity of ADL at different concentrations (0.25 500 mg/mL) was tested against MCF 7, A431 and HeLa cell lines by MTT assay. ADL exhibited potential cytotoxicity against these cell lines after 24 hours in a dose dependent manner. Thus, ADL could be a pot ent cytotoxic agent in clinical applications.
A multicriteria decision based assessment of agricultural solid wastes as potential feedstock for electricity generation in Nigeria
Authors: Salami H. A. , Lawal S. O. , Bademosi T. , Olowosokedile O. , Olalekan H. I.
Published: June 2023

An effective method of managing solid wastes from agricultural processing is through thermochemical conversion to energy-dense and carbon-neutral energy products; which relieves the issue of depleting global resources, solves the problem of over-reliance on fossil fuel, reduces the impact on the environment, and brings economic benefits. In this study, the suitability of agricultural solid wastes as potential feedstock for electricity generation in Nigeria via a combined pyrolysis–steam power plant technology was assessed. Technique for order of preference by similarity to ideal solution was used to identify the most appropriate raw material for electricity generation among the considered alternatives–rice husk, corncob, and palm kernel shell. These wastes showed high electricity generation potential (232–2077GWh per annum), high profitability index, and high carbon reduction benefit (about1428kg CO2 eq. /m3of bio-oil).
Geophysical assessment of groundwater contaminations from leachate intrusion in Amoyo dumpsite
Authors: Olatunji S. , Fauzan A.O.
Published: June 2023

The work aims to map the extent of leachate intrusion in near-surface rocks around a reclaimed dumpsite (40 years old) in Amoyo town. Sixteen very low- frequency electromagnetic (VLF - EM) profiles were distributed in the four cardinal directions around the site. Twenty-nine (29) points were sounded,  using Schlumberger approach, at all identified VLF anomalous points. The analyzed VLF-EM data revealed the presence of conductive pollutants (leachate  plumes) at the subsurface. The geo-electric sections generated from the processed VES data supported the VLF-EM results. It is concluded that (i)  leachate is still present in the rock formation of the reclaimed dumpsite several years after the abandonment and excavation of the waste materials (ii)  the shallow aquifer is at risk of contamination (iii) the low resistivity of the basement rocks signified presence of leachates.
Monitoring the maturity of Ahmeur Bouamer Autochtonous variety and determining of the optimum harvest date
Authors: Ghouila Z. , Baaliouamer A.
Published: June 2023

Morphological ampelography characteristics, technological, phenolic and tannic maturities were studied over four seasons (from 2009 to 2012) of  Ahmeur Bouamer autochtonous Algerian variety. During the four harvests, Ahmeur Bouamer's cluster has showed a high quality of morphological  parameters (weight, size, number of seeds/ berries per cluster).The weight was proportional to the size of the cluster which was moderately compact,  thus avoiding the deformation and the bursting of the berries. As For the maturity index (MI), Ahmeur Bouamer grape recorded values ranging from  31.07 to 54.95 for the four seasons; values which would make it possible to consider that the harvest would be of excellent quality (when 30 <MI <50). As  well as for total anthocyanin potential (TAP) exceeding 1000 mg / L and total polyphenol index (TPI) with values greater than 50, these values confirm that  the cluster presents high level of maturity. The monitoring of the MI every week in the phase of ripening (september-october) for 2010 and 2011  have showed that the maximum ripeness index was reached on September 27th with highest level of maturity for both harvests, date that can be  considered by the winemaker as optimal date of harvest.
Integration of remote sensing and geophysical methods for structural and lithological mapping in a part of Precambrian Basement Rocks, northern Nigeria
Authors: Olatunji S.
Published: June 2023

Landsat 8 OLI data, Aeromagnetic data, and Radial Vertical Electrical Sounding (RVES) survey data were integrated to map lithology, delineate structures  and their trends, and delineate possible mineralized zones in the area. Landsat 8 OLI data yielded a color composite image, and surface lineaments map  of the area. The aeromagnetic maps were utilized to map lithology, and subsurface structures. A radial survey confirmed the fractures derived from the  structural maps. Results classified the area into three geological units viz: migmatite, banded gneiss, and quartzite. The banded gneiss is the most  deformed and contains series of structures that are significant for mineral and groundwater explorations. Clay alteration is the most dominant in the  area, followed by iron oxide alterations. Lineament alignments are N-S, NNW-SSE, NNE-SSW, NE-SW, and E-W directions.
Fetal distress and the levels of malondialdehyde (MDA): A meta-analysis
Authors: Liu Yongli , Chi Xiuping , Qiang Zhe
Published: June 2023

Purpose: To estimate the effect of malondialdehyde (MDA) level on fetal distress.

Methods: Meta-analyses of randomized controlled interventions were performed by searching 8 electronic databases (CNKI, VIP, CBM, WANFANG,  Embase, PubMed, Cochrane, and Web of Science) from 1980 – to date for randomized controlled trials to determine any intrapartum fetal distress. A  metaanalysis within a frequentist framework was performed and the quality and inconsistency of the trials were assessed. Dual selection and data  abstraction were conducted. The methodological quality of the meta-analyses was assessed using AMSTAR, and the quality of evidence was assessed  using GRADE. Random-effect models were used to pool results from individual studies included in each meta-analysis.

Results: A total of 1720 patients received MDA tests, and the results showed that MDA value of experimental group was 1.66 higher than that of control  group. Heterogeneity between the two groups was high, suggesting that the choice of blood source significantly affected the result of meta-analysis (p <  0.05). The group of blood samples collected from mothers was highly heterogeneous, and combined with the results of 16 groups, the effective amount  reached (2.08) was significant (z = 4.29, p < 0.05). This means that MDA increase in maternal blood during maternal-fetal distress. Secondly, cord blood samples were highly heterogeneous in the collection group, and the random effect was insignificant (z = 0.94, p > 0.05).

Conclusion: Malondialdehyde level in maternal and cord blood reflects the relationship between fetal distress and adverse outcomes. Further research is  needed to confirm the extent to which they are related.
Elemene inhibits the growth and promotes apoptosis of bladder cancer cells through PTEN-Akt signaling pathway
Authors: Pei Yuhan , He Yuying , Geng Shen , Tang Cai , Dai Jiaxin , Ji Zhenshuai , Xie Cheng , Zhi Yunlai , Cai Chengkuan , Sun Fanghu
Published: June 2023

Purpose: To investigate the influence of elemene on growth and apoptotic changes in bladder cancer cells, and the involvement of the phosphatase and  tensin homologous protein (PTEN)-serine/threonine kinase (Akt) signal pathway in the process.

Methods: Human bladder cell line SV-HUC-1 and human bladder cancer cell line T24 were randomly assigned to blank control group and elemene  groups. Protein expression levels of apoptosis-related factors (Bcl-2, Bax, and caspase-3] and PTEN, Akt, and p-Akt in both cells were determined using western blot assay.

Results: In T24 cells, the protein level of Bcl-2 was significantly higher in elemene group than in blank control, while the protein expression levels of Bax  and caspase-3 in elemene group were significantly lower than the corresponding levels in blank control group (p < 0.05). The protein expression of PTEN level in T24 cells was significantly higher in elemene group than in blank control group, while protein expression level of p-Akt was significantly lower in  elemene group than in blank control (p < 0.05). The Akt protein expression was comparable in elemene and blank control groups.

Conclusion: Elemene inhibits the growth and enhances apoptosis of bladder cancer cells through a mechanism involving up-regulation of the expression  of PTEN and suppression of the expression of pAkt.
Knockdown of VAMP8 attenuates atherosclerosis and enhances the effect of simvastatin in APOE-deficient mice
Authors: Zhan Lei , Zhao Hua
Published: June 2023

Purpose: To investigate the regulatory effects of vesicle-associated membrane protein 8 (VAMP8) in atherosclerosis (AS).

Methods: VAMP8 expression was assessed using quantitative real time-polymerase chain reaction (qRT-PCR) and western blot, while H&E staining was  used to examine the morphology of arterial glandular tissues in AS mice. Lipid accumulation in mice was determined with the aid of Oil Red O staining,  whereas the apoptosis of aortic cells was evaluated by TUNEL assay.

Results: VAMP8 was highly expressed in the advanced-stage AS samples, and was  also elevated in AS mice (p < 0.01). VAMP8 protein level rose in AS mice (p < 0.01). Moreover, the aorta showed atherosclerotic lesions with intima  thickening and atherosclerotic plaques in AS group (p < 0.01). However, these changes were alleviated in VAMP8-silenced group (p < 0.01). VAMP8  silencing decreased lipid accumulation and alleviated inflammation and oxidative stress in AS mice (p < 0.01). It was observed that depletion of VAMP8  reduced aortic cell apoptosis in AS mice (p < 0.05). Furthermore, VAMP8 knockdown enhanced the effect of simvastatin on atherosclerosis (p < 0.01).  

Conclusion: Knockdown of VAMP8 alleviates AS in ApoE-deficient mice. This finding suggests that this might be a potential strategy for the prevention  and treatment of AS.
HUBUNGAN TEKANAN DARAH DANN KREATININ SERUM PADA ANGGOTA GYMNASTIK DI PUSAT KEBUGARAN KOTA KENDARI
Authors: Balaka Kemal Idris , Annisaa Nur
Published: June 2023

ABSTRACT

Creatinine is the end product of muscle creatine metabolism, synthesized in the liver, and is found in skeletal muscle, blood, and excreted in the urine. Blood pressure is a condition that describes a person's health condition. High blood pressure can be the cause of various health problems, such as heart failure, stroke, and kidney disorders. Several factors that affect creatinine levels in the blood include lifestyle such as excessive physical activity, age, habits of consuming energy drinks and lack of drinking water are trigger factors, so it is suspected that there is a correlation between blood pressure and serum creatinine. Type of research used is observational analytic, namely research that looks for variable relationships to determine whether there is a relationship between variables to be studied and then to obtain results, statistical analysis is carried out. The correlation test used is non-parametric correlation with Chi-Squareto see the correlation between blood pressure and serum creatinine, and the samples used were gymnastics members as many 30 people taken by random sampling method. The test results found that there was a relationship between blood pressure and serum creatinine, with a low significance level of 0.036 (contingency coefficient value).

Keywords: Blood pressure, creatinine, correlation, gymnastic member.

ABSTRAK

Kreatinin merupakan produk akhir dari metabolisme kreatin otot disintesis dalam hati, dan ditemukan dalam otot rangka, darah, dan dieksresikan dalam urin. Tekanan darah adalah suatu keadaan yang menggambarkan kondisi kesehatan seseorang. Tekanan darah yang tinggi dapat menjadi penyebab munculnya berbagai masalah kesehatan, seperti gagal jantung, stroke, dan gangguan pada ginjal. Beberapa faktor yang mempengaruhi kadar kreatinin dalam darah diantaranya ialah gaya hidup seperti aktivitas fisik berlebihan, usia, kebiasan mengonsumsi minuman berenergi dan kurangnya minum air putih menjadi faktor pemicu, sehingga di duga ada korelasi antara tekanan darah dan kreatinin serum. Jenis penelitian yang digunakan adalah observasional analitik yaitu penelitian yang mencari hubungan variabel untuk menentukan ada tidaknya hubungan antar variabel yang akan diteliti kemudian untuk memperoleh hasil dilakukan analisis statistik. Uji korelasi yang digunakan ialah korelasi non parametrik dengan Chi-Square untuk melihat korelasi antara tekanan darah dengan kreatinin serum. Sampel yang digunakan ialah anggota gymnastik sebanyak 30 orang yang diambil dengan metode random sampling. Hasil uji  di dapatkan bahwa terdapat hubungan antara tekanan darah dan kreatinin serum, dengan tingkat signifikansi yang rendah yaitu sebesar 0.036 (nilai contingency coefficient).

Kata kunci: Tekanan darah, kreatinin, Anggota Gymnastik.
UJI DAYA HAMBAT EKSTRAK ETANOL BINTANG LAUT BERTANDUK (Protoreaster nodosus) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus
Authors: Fauziah Yulianti , Wulaisfan Randa
Published: June 2023

ABSTRAK 

Bintang laut bertanduk merupakan salah satu biota laut yang digunakan sebagai obat tradisional. Salah satunya adalah pengobatan infeksi. Infeksi merupakan salah satu penyebab penyakit yang sering terjadi di daerah yang beriklim tropis khususnya Indonesia. Salah satu infeksi yang sering terjadi adalah infeksi pada kulit yang disebabkan oleh bakteri Staphylococcus aureus. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol bintang laut bertanduk dapat menghambat pertumbuhan bakteri Staphylococcus aureus.

Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian eksperimental yang terdiri atas lima perlakuan dan tiga kali pengulangan dengan menggunakan metode pengujian paper disk. Sampel uji yang diteliti adalah bintang laut bertanduk (Protoreaster nodosus) yang dilarutkan dalam DMSO 10% hingga didapatkan varian konsentrasi 5%, 10%, dan15% kemudian dilakukan uji daya hambat terhadap bakteri Staphylococcus aureus.

Hasil penelitian menunjukkan bahwa ekstrak bintang laut bertanduk menghambat pertumbuhan bakteri Staphylococcus aureus masing-masing konsentrasi 5%, 10% dan 15% yakni 5,99mm, 6,69mm dan7,64mm. Berdasarkan hasil tersebut dapat disimpulkan bahwa ekstrak etanol bintang laut bertanduk (Protoreaster nodosus) dapat menghambat pertumbuhan bakteri Staphylococcus aureus secara signifikan.

Kata kunci :Zonahambat,  Bintang Laut Bertanduk, Staphylococcus aureus.

ABSTRACT

Horned starfish are one of the marine biota used as traditional medicine. One of them is the treatment of infections. Infection is one of the causes of diseases that often occur in the tropics, especially Indonesia. One infection that often occurs is an infection of the skin caused by Staphylococcus aureus. This study aims to determine whether the horned starfish ethanol extract can inhibit the growth of Staphylococcus aureus bacteria. This type of research used in this study is an experimental study consisting of five treatments and three repetitions using a diskette testing method. The test sample studied was a horned starfish (Protoreasternodosus) dissolved in DMSO 10% to 5%, 10%, and 15% of the variant of concentration was obtained then the inhibitory test was performed on Staphylococcus aureus bacteria. The results showed that the horned starfish extract inhibited the growth of Staphylococcus aureus, each concentrations of 5%, 10% and 15% respectively 5.99 mm, 6.69 mm and 7.64 mm. Based on these results it can be concluded that the ethanol extract of the horned starfish (Protoreasternodosus) can significantly inhibit the growth of Staphylococcus aureus bacteria.

Keywords: Inhibited zone, Horn Star, Staphylococcus aureus.
EFEKTIVITAS SERBUK DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb) TERHADAP KEMATIAN LARVA Aedes aegypti
Authors: Apriyanto Apriyanto
Published: June 2023

ABSTRAKDemam berdarah dengue (DBD) adalah penyakit infeksi yang di sebabkan oleh satu dari 4 virus dengue berbeda dan ditularkan melalui nyamuk terutama Aedes aegypti dan Aedes albopictus. Penggunaan serbuk daun pandanwangi (Pandanus amaryllifolius Roxb) mengandung insektisida botanik (alami) karena mengandung alkaloida,saponin, flavonoid, dan minyak atsiri. Kandungan kandungan daun serbuk daun pandan wangi dapat menghambatbahkan membunuh larva nyamuk. Jenis penelitian yang digunakan adalah eksperimen dengan menggunakananalisis regresi linear. Populasi dalam penelitian ini adalah daun pandan wangi (Pandanus amryllifolius Roxb),sampel dalam penelitian ini adalah serbuk daun pandan wangi (Pandanus amryllifolius Roxb). Hasil penelitian inidiperoleh rata-rata persentase kematian larva Aedes aegypti dengan menggunakan bahan uji yaitu serbuk daunpandan wangi (Pandanus amaryllifolius Roxb) dengan konsentrasi 100 mg/mL yaitu 9,2%, 200 mg/mL yaitu10,7%, 300 mg/mL yaitu 12%, dan 400 mg/mL yaitu 18,7%. Kata Kunci : Larvasida, Pandanus amaryllifolius Roxb, Aedes aegypti ABSTRACTDengue hemorrhagic fever (DHF) is an infectious disease caused by one of four different dengue viruses and is transmitted through mosquitoes, especially Aedes aegypti and Aedes albopictus. The use of fragrant pandan leafpowder (Pandanus amaryllifolius Roxb) contains botanical insecticides (natural) because they contain alkaloids,saponins, flavonoids, and essential oils. The content of leaves of fragrant pandan leaf powder can inhibit even killmosquito larvae. The type of research used experiments using linear regression analysis. The population in thisstudy was fragrant pandan leaves (Pandanus amryllifolius Roxb), the sample in this study was powdered fragrantpandan leaves (Pandanus amryllifolius Roxb). The results of this study obtained an average percentage ofmortality of Aedes aegypti larvae by using the test material namely fragrant pandan leaf powder (Pandanusamaryllifolius Roxb) with a concentration of 100 mg/mL which is 9,2%, a concentration of 200 mg/mL which is 10,7%, a concentration of 300 mg/mL that is 12%, 400 mg/mL which is 18,7%. Keywords : Larvacides, Pandanus amaryllifolius Roxb, Aedes aegypti
UJI EFEKTIVITAS EKSTRAK DAUN TEMBELEKAN (Lantana camara Linn) DALAM BENTUK GRANUL PADA BUNGA PINK TERHADAP KEMATIAN LARVA Aedes SP
Authors: Apriyanto Apriyanto , Balaka Kemal Idris , Zulkarnain Riska Amelia
Published: June 2023

Dengue Hemorrhagic Fever (DHF) is a public health problem that appears mostly in the tropics and subtropics in the world. DHF including acute diseases caused by viral infections under the mosquitoes of Aedes aegypti and Aedes Albopictus. In Tembelekan leaves (Lantana camara Linn) contain active compounds namely flavonoids, alkaloids, saponins and tannins which can inhibit the development of mosquitoes and larvae. The purpose of this study was to determine the results of the effectiveness of the extract of the Tembelekan leaf (Lantana camara Linn) in the form of granules as larvicide against the death of larvae of Aedes sp. This research was conducted experimentally with variations in the concentration of 7%, 8%, 9%. 220 Aedes sp larvae were used, divided into 3 concentrations of granules simplicia of the Tembelekan leaves, 7%, 8%, and 9% with 3 repetitions. Abate 1% is used as a positive control. Each concentration contains 20 larvae in 100 mL of water. Observations were made by counting the number of dead larvae. The results of the study showed that the total mortality of larvae using granules simplicia Tembelekan leaves (Lantana camara Linn) at a concentration of 7% by (26%), concentration of 8% as big (53%) at a concentration of 9% by (81%)

Keywords: larvae of Aedes sp, Leaves tembelekan, Larvasida
Cache-Timing Attack Against HQC
Authors: Huang Senyang , Sim Rui Qi , Chuengsatiansup Chitchanok , Guo Qian , Johansson Thomas
Published: June 2023

In this paper, we present the first chosen-ciphertext (CC) cache-timing attacks on the reference implementation of HQC. We build a cache-timing based distinguisher for implementing a plaintext-checking (PC) oracle. The PC oracle uses side-channel information to check if a given ciphertext decrypts to a given message. This is done by identifying a vulnerability during the generating process of two vectors in the reference implementation of HQC. We also propose a new method of using PC oracles for chosen-ciphertext side-channel attacks against HQC, which may have independent interest.We show a general proof-of-concept attack, where we use the Flush+Reload technique and also derive, in more detail, a practical attack on an HQC execution on Intel SGX, where the Prime+Probe technique is used. We show the exact path to do key recovery by explaining the detailed steps, using the PC oracle. In both scenarios, the new attack requires 53, 857 traces on average with much fewer PC oracle calls than the timing attack of Guo et al. CHES 2022 on an HQC implementation.
Enabling FrodoKEM on Embedded Devices
Authors: Bos Joppe W. , Bronchain Olivier , Custers Frank , Renes Joost , Verbakel Denise , Van Vredendaal Christine
Published: June 2023

FrodoKEM is a lattice-based Key Encapsulation Mechanism (KEM) based on unstructured lattices. From a security point of view this makes it a conservative option to achieve post-quantum security, hence why it is favored by several European authorities (e.g., German BSI and French ANSSI). Relying on unstructured instead of structured lattices (e.g., CRYSTALS-Kyber) comes at the cost of additional memory usage, which is particularly critical for embedded security applications such as smart cards. For example, prior FrodoKEM-640 implementations (using AES) on Cortex-M4 require more than 80 kB of stack making it impossible to run on some embedded systems. In this work, we explore several stack reduction strategies and the resulting time versus memory trade-offs. Concretely, we reduce the stack consumption of FrodoKEM by a factor 2–3x compared to the smallest known implementations with almost no impact on performance. We also present various time-memory trade-offs going as low as 8 kB for all AES parameter sets, and below 4 kB for FrodoKEM-640. By introducing a minor tweak to the FrodoKEM specifications, we additionally reduce the stack consumption down to 8 kB for all the SHAKE versions. As a result, this work enables FrodoKEM on more resource constrained embedded systems.
Developing Task Persistence Skills in College Students with Hard of Hearing Using Strategic Content Learning
Authors: Onyishi Charity Neejide
Published: June 2023

Poor task persistence is a major inhibitor of effective learning among students with hearing impairment. This study investigated the effect of strategic content learning (SCL) on poor task persistence of students with hearing loss in Nigeria. The study adopted a pretest-posttest control group design.  A total of 117 participants from four special schools for hearing impaired in South-East Nigeria completed a task persistence scale at pre-treatment, post-treatment, and follow-up. Intervention was carried out for nine weeks using strategic content learning program manual. Data collected were analyzed using repeated-measures analysis of variance, chi-square, and t-test. Results revealed that task persistence of hearing impaired college students of SCL group were significantly improved compared to those in waitlist control group at the end of the intervention. Follow-up tests conducted after three months and six months revealed that the significant improvement in task persistence of participants in the experimental group was sustained. Result of the current study show that SCL is an effective strategy straining approach that can improve students’ task persistence in different areas of learning. Further studies could be conducted in Nigeria and other countries to investigate the efficacy of SCL in improving self-efficacy and volition among diverse populations of students.
Rachel Vennya's Directive Speech Actions in Promoting Goods and Their Utilization in Advertising Text Learning
Authors: Derita Delvia , Agustina
Published: June 2023

This research aims to explain Rachel Vennya`s (RV) directive speech acts in promoting goods and services and their use in learning advertising texts and slogans. This type of research is qualitative research with a descriptive method. The data for this research is the speech of celebrities from the RV program when promoting goods and services. Data source is RV's personal Instagram account taken from posts starting November 2020 to November 2022. Data collection uses media review techniques by downloading recordings of these promotional posts. Data validation was carried out through triangulation techniques, while data processing was carried out using three stages, namely the analysis, discussion and conclusion stages. Three findings were obtained from this research. First, there are four types of directive speech acts of RV in promoting goods and services, namely the speech acts of suggesting, commanding, advising, and pleading. Third, directive speech acts and speech strategies can be used as learning media for making advertising texts and slogans in schools. Finally, the research it can be used as a teaching medium in making advertising text and slogans to assist students in producing advertising text and slogans at school.
Education Should Embrace All Potential: Students’ Reflective Essays on the Meaning of Merdeka Belajar
Authors: Simamora Roy Martin , Pasaribu Daniel
Published: June 2023

This research delves into the perspectives of students regarding the concept of merdeka belajar, as evidenced in their essays for the philosophy of education course. The selected reflection essays are analyzed to explore how students connect their learning experiences to the idea of merdeka belajar. The study aims to uncover how students interpret and apply merdeka belajar to their own learning, through the analysis of forty-five essays submitted for the philosophy of education course, with a focus on thirteen selected students. The research was carried out over the course of May 2022. The analysis reveals seven main themes in the essays, which include the students' understanding of merdeka belajar, their experiences with family and teacher involvement, their views on children's learning abilities, the role of schools in students' lives, experiential learning, diversity and equality in education, and reflections from prospective teachers. The study highlights the importance of promoting merdeka belajar in education and identifies the challenges students face in becoming self-directed learners, along with potential solutions to address these challenges.
Research Trend of Inquiry Learning in Elementary School in the Last 10 Years: To Determine the Opportunities in the Future
Authors: Setiani Rahyu
Published: June 2023

Inquiry Learning in Elementary School research has evolved in the last ten years, making it an interesting topic to research to understand the trends and developments of Inquiry Learning in Elementary School so that it becomes a research opportunity. This study aims to analyze research trends, researchers' contributions, and the most researched research topics on the topic of Inquiry in Elementary School in education over the past ten years and identify potential research topics related to Inquiry in Elementary School in Education in the future. This study uses the bibliometric analysis method using Google Scholar database and Software VOSviewer, where 138,000 articles were obtained. The results of the bibliometric analysis show that Inquiry Learning in Elementary School research has experienced a consistent decline in the last ten years. This becomes the next challenge, and opportunity for future research. Further research related to Inquiry Learning in Elementary School can be used and applied with a STEM-based approach namely Science, technology, engineering, and mathematics. This is because the stem-based Inquiry model can improve students' critical thinking and problem-solving skills. This study has limitations, namely only using one database, Google Scholar, to obtain research data. Therefore, it is recommended that Inquiry Learning in Elementary School research be carried out using other databases besides Google Scholar to obtain more extensive data.
Educația competențelor sociale ale studenților – obiectiv al universității contemporane
Authors: MUSIENCO Natalia
Published: June 2023

The importance of developing social skills in educational institutions engaged in innovative activities lies in the fact that a person is the main intellectual resource that provides value to the products created, thus becoming the basis of development and innovation. This article presents the results of a descriptive study, obtained by applying the quasi-experimental methodology, as a form of intervention on ULIM students, in orderto develop social skills within professional trainings. The obtained results show the development path of social skills in 25 students from year 1 to the end of year 3 of study. The results from the test-retest showed an increase in the averages for the competence of self-expression in communication, a harmonization of the assessment of one’s own social skills, harmonized the students’ capacity for objective assessment, overestimations being removed, but also through the development of social skills, the level of adaptability and subjective assessment of the quality of life increased.
Destructive manifestations in the emotional and behavioral sphere of seafarers
Authors: SHEVCHENKO Rosina Petrovna , PAKHMURNY Victor Anatolyevich , CHUMAIEVA Yuliia , GROSHEV Dmitry Ivanovich
Published: June 2023

The article analyzes the destructive manifestations in the emotional and behavioral spheres of seafarers in a sample of 40 seafarers. In the research we studied the behavioral patterns of sailors according to their professional status: senior officers, officers, deck crew, engine crew, and support staff. We also examined the correlation between the characteristics of destructive manifestations and the professional status of seafarers. Statistical analysis revealed unfavorable assertiveness scores in all five study groups. This suggests that the sailors in the studied sample, as representatives of an extreme profession, have a constant willingness to enter into conflictual interaction. For people in the seafaring profession, who operate in extreme conditions, it is necessary to develop and implement developmental and psychotherapeutic psychological intervention programs.