bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptación y Aplicación de la Escala de Intencionalidad de Seguir Practicando Baloncesto de Iniciación
Authors: Arias-Estero José L. , Morales-Belando María T.
Published: August 2023

Son varios los trabajos que realzan la importancia de que las escalas psicológicas sean validadas en contextos en los que posteriormente van a ser utilizadas. Esta es una medida que enriquece la validez y fiabilidad del instrumento. La tendencia es utilizar escalas específicas para cada deporte. Los objetivos de este estudio fueron: (a) conocer las características psicométricas de la adaptación de la escala de intencionalidad de ser físicamente activo para jugadores de baloncesto federado de 9-12 años y (b) comprobar esta medida en esa misma etapa. Participaron 619 jugadores. Se adaptó la escala y se obtuvo la validación de contenido y comprensión. Posteriormente se analizó la validez de constructo (análisis factorial exploratorio ―todos los ítems se agruparon en un factor― y confirmatorio ―χ2/df = 3.94; SRMR = 0.015; GFI = 0.93; CFI = 0.95; TLI = 0.93; RMSEA = 0.04) y criterio (r = 0.74; p < 0.000), la consistencia interna (α de Cronbach = 0.88). La intencionalidad de seguir practicando baloncesto fue alta (M = 4.64; SD = 0.43). La escala resulta un instrumento específico, contextualizado, válido y fiable, lo que fue reforzado por altos valores mostrados por los participantes.
Relação entre as Cargas de Treinamento, Recuperação e Burnout em Atletas de Voleibol
Authors: Vieira de Morais Adelita , Caetano de Andrade Nogueira Francine , Diniz da Silva Cristiano , Gattás Bara Filho Maurício
Published: August 2023

O objetivo deste estudo foi verificar as relações do burnout com as cargas de treino e recuperação durante a temporada. Participaram do estudo 14 jogadores de voleibol masculino. Foram aplicados o QBA e o RESTQ-Sport em 4 momentos da temporada. A carga interna foi coletada diariamente pela PSE da sessão. Os resultados indicaram baixos índices do burnout total (Fr = 2,95, p=0,398) e suas dimensões nos momentos da temporada. No tocante as cargas, observou-se um aumento da pré-temporada para os demais momentos (Fr= 13,80, p=0,003), e em seguida, não houve diferenças significativas de um momento para o outro (p>0,05). Sobre a relação do burnout com a carga de treino, observou-se uma correlação positiva entre burnout total (rho= 0,76, p< 0,01) e a dimensão exaustão física e emocional (rho= 0,73, p< 0,01) na segunda fase da temporada. Sobre o estresse e recuperação, os atletas apresentaram um comportamento estável durante os quatro momentos de coleta. E sobre a relação do estresse e recuperação com burnout, foram encontradas correlações em todos os momentos com diversas variáveis. Conclui-se que houve uma distribuição adequada das cargas de treino, proporcionando uma baixa percepção de burnout nos atletas.
Pendekatan Saintifik Untuk Meningkatkan Kreativitas Anak Usia Dini
Authors: Mutamimah Mutamimah , Siswanto Joko , Purnamasari Iin
Published: August 2023

Early Childhood Education is the most basic level of education which is expected to be a strong foundation for maximizing children's abilities so that they are able to live independently and benefit the environment. The coaching program must be designed, planned, and implemented carefully according to the characteristics of the child. Learning in early childhood is held interactively, fun and motivates children to participate actively. The 2013 curriculum includes the development of aspects of the curriculum structure, the learning process with a scientific approach, and an authentic assessment. Scientific approach (scientific) is learning based on facts/phenomena that can be explained by logical thinking, inspiring students to think critically, analytically and accurately in identifying, understanding and solving problems. For this reason, researchers are interested in examining the effectiveness of the scientific approach with the help of the natural environment to increase the creativity of children aged in TK Pembina Limpung. The data were obtained from 30 children which were divided into the control group and the experimental group. Then it was analyzed using SPSS Version 19. The results showed that in the experimental class the scientific approach assisted by the natural environment was quite effective in increasing the creativity of children in the Pembina Kindergarten, Limpung sub-district.
UPAYA PENINGKATAN KETERAMPILAN MOTORIK HALUS ANAK MELALUI KEGIATAN MENGGUNTING DAN MENEMPEL BAGI ANAK KELOMPOK B TK PELITA HATI KUARO TAHUN PELAJARAN 2020/2021
Authors: Ernawati Ernawati
Published: August 2023

Berdasarkan pengamatan yang dilakukan di TK Pelita Hati ditemukannya belum mampu untuk mengkoordinasikan Keterampilan motorik halusnya baik itu  memegang alat tulis,mencocok menggunting dan menempel dengan baik. Terkadang anak merasa cepat jenuh dikarnakan mereka tidak mampu mengerjakan tugas yang diberikan Penelitian Tindakan Kelas dilakukan dengan tujuan tercapainya perkembangan aspek motorik halus anak melalui kegiatan mencocok,membuat kandang sapi dan domba serta membuat miniatur peternakan.
Yang menjadi subjek dalam penelitian adalah anak pada kelompok B dengan jumlah 5 orang anak. Yang berlangsung selama 3 siklus.
Perolehan hasil dari Siklus I,Siklus II dan Siklus III dalam meningkatkan kemampuan motorik halus anak melalui kegiatan menggunting dan menempel , dapat dkatakan  bahwa kemampuan dari 5 anak, yang  berkembang sesuai harapan  tidak ada, pada Siklus I sebanyak 1 anak atau sebesar 20% sedangkan pada siklus II adalah sebanyak 2 anak atau sebesar 40% dan pada siklus III menjadi 3 anak atau sebsar 60% dan 1 anak berkembang sangat baik atau sebesar 20% sehingga anak yang mampu menggunting dan menempel ( berkembang sesuai harapan ) mengalami peningkatan sebanyak 3 anak atau sebesar 60%. Dan untuk Kemampuan Berkembang sangat baik yang pada siklus I tidak ada pada siklus II menjadi 1 anak atau naik 20%
Training of Trainer Critical Thinking di Pusat Pendidikan Banyu Biru
Authors: Yanuartha Rizki Amalia , Hergianasari Putri
Published: August 2023

Berpikir kritis diperlukan dalam berbagai situasi sehingga dapat dengan secara rasional memutuskan serta membuat solusi atas permasalahan yang sedang dihadapi. Pada pengabdian masyarakat ini, penulis melakukan pelatihan berpikir kritis pada fasilitator Binmas Polri di Banyu Biru. Peserta merupakan fasilitator yang memberikan sosialisasi kepada calon Bhayangkara Pembina Keamanan dan Ketertiban Masyarakat (Bhabinkamtibmas). Tujuan pengabdian masyarakat dengan peserta di Pusdik Banyu Biru karena polisi dituntut untuk mampu menjaga kemanusiaan, meningkatkan kualitas hidup, dan menjaga peradaban. menggunakan metode Training of Trainer dengan Focus Group Discussion dengan peserta sejumlah 25 orang. Diharapkan dengan pengabdian masyarakat ini peserta mempunyai kemampuan berpikir kritis yang memungkinkan untuk mengevaluasi situasi dengan cepat, efisien, dan aman. karena berpikir kritis merupakan bagian integral dari pengambilan keputusan penegakan hukum.
Estimating the impact of single pill combination therapy for hypertension: projections of patient outcomes in Italy
Authors: Borghi Claudio , Granados Denis
Published: August 2023

Introduction

Hypertension affects almost a third of the Italian population and is a major risk factor for cardiovascular disease. Management of hypertension is often hindered by poor adherence to complex treatment regimens. This analysis aimed to estimate the 10-year clinical outcomes associated with single pill combination (SPC) therapies compared with other treatment pathways for the management of hypertension in Italy.

Methods

A microsimulation modeling approach was used to project health outcomes over a 10-year period for people with hypertension. Input data for four treatment pathways [current treatment practices (CTP), single drug with dosage titration then sequential addition of other agents (start low and go slow, SLGS), free choice combination with multiple pills (FCC) and SPC] were sourced from the Global Burden of Disease 2017 data set. The model simulated clinical outcomes for 1 000 000 individuals in each treatment pathway, including mortality, chronic kidney disease (CKD), stroke, ischemic heart disease (IHD) and disability-adjusted life years (DALYs).

Results

Through improved adherence, SPC was projected to improve clinical outcomes versus CTP, SLGS, and FCC. SPC was associated with reductions in mortality, incidence of clinical events, and DALYs versus CTP of 5.4%, 11.5%, and 5.7%, respectively. SLGS and FCC were associated with improvements in clinical outcomes versus CTP, but smaller improvements than those associated with SPC.

Conclusions

Over 10 years, combination therapies (including SPC and FCC) were projected to reduce the burden of hypertension compared with conventional management approaches in Italy. Due to higher adherence, SPC was associated with the greatest overall benefits versus other regimens.
The multidisciplinary Heart Team approach for patients with cardiovascular disease: a step towards personalized medicine
Authors: Mazza Andrea , Iafrancesco Mauro , Bruno Piergiorgio , Chiariello Giovanni Alfonso , Trani Carlo , Burzotta Francesco , Cammertoni Federico , Pasquini Annalisa , Diana Giovanni , Rosenhek Raphael , Liuzzo Giovanna , Rabini Alessia , Flex Andrea , Raweh Abdallah , Crea Filippo , Massetti Massimo
Published: August 2023

Aims

Despite general agreement on the benefits of the Heart Team approach for patients with cardiac diseases, few data are available on its real impact on the decision-making process. The aim of the study is to define the evolution over time of the level of agreement with the systematic discussion of patients in the Heart Team and to evaluate the adherence to the Heart Team recommendations and the impact of the Heart Team on the clinical outcome of the patients.

Methods

In 2015--2016, an experienced cardiac surgeon and a cardiologist independently reviewed clinical data of a series of 100 patients (Group 1, G1) and subsequently for each patient recommended treatment (surgical, percutaneous, hybrid or medical therapy) or further diagnostic investigations. The next day, each case was discussed by the Hospital Heart Team. The Heart Team recommendation, the subsequent treatment received by the patient and the in-hospital outcome were recorded. The same study procedure was repeated in 2017 in a second (G2) and in 2018 in a third (G3) group, both of them including 100 patients.

Results

Complete agreement in treatment selection by the cardiac surgeon, cardiologist and the Heart Team was observed in 43% of cases in G1 and in 70% and 68% in G2 and G3, respectively (G1 vs. G2: P < 0.001, G1 vs. G3: P = 0.01, G2 vs. G3: P = 0.30). Agreement was less frequent in patients with a higher risk profile and in patients with aortic valve stenosis. The Heart Team decision was implemented in 95% of cases with a 30-day mortality of 0.67%.

Conclusion

Agreement in treatment selection among the cardiac surgeon, cardiologist and Heart Team appears to be low in the initial experience. Subsequently, it seems to steadily increase over time up to a limit, when it reaches a plateau of stable results. Heart Team clinical cases discussion, based on both guidelines and multidisciplinary experience, represents a key step in defining the best patient treatment pathway, potentially improving the decision-making process and clinical results.
Echocardiographic screening in pediatric asymptomatic or paucisymptomatic coronavirus disease 2019 outpatients: is it a useful test or an excess of zeal?
Authors: Gasparini Paolo Alberto , Lodi Elisa , Rodighiero Eleonora , Rosero Morales Jonathan , Fantini Giuseppe , Modena Maria Grazia
Published: August 2023

Introduction

Data regarding echocardiographic findings during follow-up of asymptomatic or pauci-symptomatic coronavirus disease 2019 (COVID-19) are scarce in pediatric patients. The aim of the present study is to assess post-COVID-19 sequelae through echocardiography in children who have experienced mild SARS-CoV-2.

Methods

This single-center, retrospective, observational study enrolled a cohort of 133 pediatric outpatients, born between 2005 and 2022, with a history of asymptomatic or paucisymptomatic SARS-CoV-2 infection, who underwent transthoracic echocardiographic (TTE) evaluation at an outpatient pediatric clinic in Northern Italy.

Results

The percentage of the pediatric activity of the clinic which was focused on post-COVID evaluation was not negligible, representing almost 10% of the ∼1500 pediatric patients examined from 1 January 2021 to 31 August 2022. According to ACEP classification, children enrolled in this study had previously experienced in 72.9% (97) asymptomatic COVID-19 and nearly 27% (36) a mild illness. Clinical and instrumental examinations did not show any relevant abnormality in the functional [left ventricular ejection fraction (LVEF), tricuspid annular plane systolic excursion (TAPSE), pulmonary artery systolic pressure (PASP)] or structural [interventricular septum diameter (IVSd), left ventricular internal diameter (LViD, end-diastolic volume (EDV), left atrium volume (LAV)] parameters examined related to SARS-CoV-2 infection in the total of 133 children.

Conclusion

According to our results, children who experienced an asymptomatic or mild SARS-CoV-2 infection should not be systematically investigated with second-level techniques, such as TTE, in the absence of clinical suspicion or other risk conditions such as congenital heart diseases, comorbidities or risk factors.
Adapting to change during the pandemic: The impact of COVID-19 on people living with HIV, and their coping strategies
Authors: Cane Tam Chipawe
Published: August 2023

Background: COVID-19 lockdowns led to people living with HIV experiencing lack of social connectedness, social isolation, difficulties with using technology and accessing health care and support services easily. The presented study sought to understand the challenges caused by COVID-19 and coping strategies. Methods: The study was conducted using focus groups with nineteen participants. Participants lost social connectedness, struggled to learn technology, and felt isolated in the absence of face to face peer support activities provided by HIV community support services. Participants employed a range of positive coping strategies including appreciation of the outdoors and volunteering. Conclusion: People living with value social contact and face-face support offered through HIV voluntary sector organisations. The absence of this led to compromised social and emotional wellbeing. This focus group-based research with provision of communal lunch however, played a part in addressing isolation, appreciation of social contact and limiting the psychological impact caused by COVID-19 lockdowns.
PANDEMIA DO COVID-19 E A SAÚDE MENTAL DOS ENFERMEIROS DA ATENÇÃO PRIMÁRIA À SAÚDE
Authors: Sanitá Gabriela Lima , Ribeiro Camila Cristiane Formaggi Sales , Moraes Aluana , Girardello Debora Tatiane Feiber , Rodrigues Daisy Cristina
Published: August 2023

A Atenção Primária à Saúde (APS) é a base de conjuntos de sistemas de saúde com incremento de resolutividades para atendimento de demandas individuais, familiares e coletivas. Com a propagação da pandemia, os serviços de saúde foram sobrecarregados com casos suspeitos e confirmados de Covid-19 e, dando o impacto da negação coletiva, sobrecarregados com necessidades relacionadas à saúde mental, incluindo a saúde, causadas pela pandemia. Objetivo: Analisar os impactos da pandemia do covid-19 na saúde mental dos enfermeiros da atenção primária. Metodologia: Pesquisa descritiva e exploratória, com abordagem qualitativa, realizada nas Unidade Básica de Saúde e Unidades de Saúde da Família de um município do Oeste do Paraná, com enfermeiros que trabalharam na linha de frente para o atendimento aos pacientes com Covid-19. A coleta de dados foi realizada por meio de entrevistas estruturadas por um roteiro de perguntas, de forma individual. Os dados de caracterização dos enfermeiros foram analisados descritivamente. Os áudios gravados foram transcritos na íntegra e as entrevistas analisadas utilizando a técnica de análise de conteúdo. O projeto de pesquisa foi aprovado pelo Comitê de Ética em Pesquisa, conforme o parecer nº 5.503.523/2022. Resultados: A análise de conteúdo, realizada a partir dos relatos obtidos, resultou em duas categorias temáticas. A primeira categoria “Covid-19 e os reflexos na saúde mental das enfermeiras”, analisou a saúde mental dos profissionais que estão sentindo sobrecarregados no trabalho e com esgotamento mental. A segunda categoria “Covid-19 e as mudanças na rotina de trabalho e vida pessoal” apresentou impacto na utilização dos equipamentos de proteção individual, dificuldade em perder colegas de trabalhos ou familiares por conta do Covid-19, impactando ainda mais no desgaste emocional e no sofrimento psíquico. Considerações finais:  A realização do presente estudo demostrou que a pandemia causou impacto psicológico, podendo desenvolver estresse futuramente, por estar causando a sobrecarga no trabalho, tendo dificuldade em voltar a rotina.
ASPECTS OF THE EPIDEMIOLOGICAL DYNAMICS OF ACQUIRED SYPHILIS AND GESTATIONAL SYPHILIS BETWEEN 2010 AND 2021 IN A STATE OF THE NORTHEAST REGION OF BRAZIL
Authors: Mendonça Alania Frank , Jansen Ana Carla Silva , Barbosa Eldevan da Silva , De Sousa Larissa Rodrigues , Mendonça Rakel Gomes , De Araújo Giovanna Rotondo , Silva Sâmia Amélia Mendes , Bezerra Juliana Maria Trindade , Pinho Jaqueline Diniz
Published: August 2023

To characterize the epidemiological dynamics of acquired syphilis and gestational syphilis in the state of Maranhão, between 2010 and 2021. Methods: Confirmed cases of acquired syphilis between 2010 and 2021 and of gestational syphilis between 2010 and 2020, in the state of Maranhão, available by the Sistema de Informação de Agravos de Notificação (SINAN) were analyzed. Results: The year 2018 had the highest number of reports of acquired syphilis (1.787 cases; p < 0.0001). The municipality of Duque Bacelar (East Mesoregion) had the highest incidence rate (285.5 per 100,000 inhabitants), for acquired syphilis, in the triennium 2016 to 2018. Regarding gestational syphilis, the year 2018 also stood out (1,892 cases; p < 0.0001) as the one with the highest number of records. The municipality of Buriticupu (West Mesoregion) had the highest detection rate of gestational syphilis (42.4 per 1,000 live births) in the biennium 2019 and 2020. Conclusions: The data presented showed municipalities with higher rates of acquired syphilis and gestational syphilis, concentrating located respectively in the East and West Mesoregions of the state of Maranhão. The findings obtained in the present study gather useful information for monitoring areas with a high incidence of the disease, thus contributing to the discussion and implementation of effective strategies to reduce cases.
CARACTERÍSTICAS ASSOCIADAS AO CONHECIMENTO SOBRE AS VIAS DE PARTO EM GESTANTES
Authors: Canato Gláucia Maria , Ferracioli Patrícia Louise Rodrigues Varela , Pesce Giovanna Brichi , Christinelli Heloá Costa Borim , De Melo Willian Augusto , Ferracioli Gabriela Varela , Dias Jaqueline , Pereira Ana Carolina Simões
Published: August 2023

Objetivo: identificar as características associadas ao conhecimento sobre as vias de parto em gestantes. Método: estudo epidemiológico, exploratório, de corte transversal. A amostra foi compreendida por gestantes adultas residentes em Paranavaí, Paraná. A amostra foi constituída por 384 gestantes e a coleta de dados foi realizada no período de 22 de dezembro de 2020 a 19 de abril de 2021 por meio de um questionário que abordou sobre características sociodemográficas, pré concepcionais e da gestação atual bem como sobre o conhecimento da gestante sobre as vias de parto. Os dados coletados foram organizados e tabulados em uma planilha Excel® e posteriormente, analisados, utilizando-se os softwares Epi Info® onde foram analisados por meio de estatística descritiva e inferencial. Resultados: as características sociodemográficas apresentaram impacto no conhecimento apenas sobre o parto normal, sendo que ter menos de 8 anos de estudo e estar desempregada foram significativas para a falta de conhecimento sobre esta via de parto. Os dados relacionados à gestação atual não apresentaram impacto significativo no conhecimento da gestante sobre as vias de parto. Em relação às características da gestação anterior, as mulheres que não tiveram parto cesáreo anterior e as que tiveram parto normal anteriormente não sabiam sobre parto cesáreo, e as que fizeram parto cesáreo anteriormente desconheciam sobre o parto normal. Conclusões: de modo geral, as características sociodemográficas e as experiências gestacionais impactam no conhecimento sobre as vias de parto.
PACIENTES NEUROPSIQUIÁTRICOS E OS BENEFÍCIOS DO TRATAMENTO COM FITOCANABINÓIDES
Authors: De Oliveira Maria Carolina Rodrigues , Zauza Gabriela Fernandes , De Oliveira Júnior Wilson Paes , Torres-da-Silva Kelly Regina , Machado Aline Rafaela da Silva Rodrigues , Machado Alex Martins , Da Silva André Valério
Published: August 2023

presente revisão visa sumarizar os estudos que abordam o uso de fitocanabinóides em pacientes com doenças neuropsiquiátricas, abordando os benefícios e possíveis efeitos adversos que podem ser observados. Foi realizada uma revisão integrativa de literatura com descritores MeSH: Cannabis, Medical Marijuana, Neurology, Neuropsychiatry e as bases de dados: PubMed, MEDLINE, CINAHL, SCOPUS, Web of Science e SciELO. Selecionou-se artigos entre 2015 a 2021 utilizando como critérios de inclusão, artigos que abordassem sobre o uso de fitocanabinoides em pacientes com doenças neurológicas e/ou psiquiátricas, disponíveis integralmente nos bancos de dados sem restrição de idioma. Após análise, foram encontrados 15 artigos, que evidenciaram benefícios como: propriedades ansiolíticas, antiepilépticas, antiparkinsonianas, antipsicóticas, de estabilização de humor, além de ser benéfico na regulação do sono, na Síndrome de Tourette, na demência, dores crônicas, amenização de sintomas eméticos dos tratamentos oncológicos e da espasticidade na esclerose múltipla, no TEPT e no autismo. Além disso, os fitocanabinoides parecem ter propriedades anti-inflamatórias e de neuroproteção. Entretanto, efeitos colaterais também foram observados, sendo os principais: piora no desempenho em testes cognitivos, sintomas gastrointestinais, sonolência, agitação, piora de alguns transtornos psiquiátricos, diminuição da concentração, aumento da ansiedade social, bem como boca e olhos secos. Conclui-se portanto que os fitocanabinóides podem apresentar ação terapêutica benéfica no tratamento de condições neuropsiquiátricas, tratamento de doenças neurodegenerativas, propriedades anti-inflamatórias e neuroprotetoras e tratamento de dores crônicas, entretanto devem ser considerados e monitorados os efeitos adversos em cada paciente.
Esteroides anabolizantes androgênicos e seus efeitos colaterais
Authors: Pereira Jessica Ewllynn Teixeira , Pereira Edson Júnio , Gomes Gabriela Moraes , Santos Iasmim  Prates e , Rezende Lucas Andrade de , Cavalcante Marcos Francisco , Silva Constanza Thaise Xavier
Published: August 2023

Objetivo: Descrever os efeitos colaterais no uso de esteroides anabolizantes androgênicos em adultos. Métodos: Revisão integrativa de literatura, nas bases de dados realizada na National Library of Medicine (PubMed), Biblioteca Virtual em Saúde (BVS) e Scientific Eletronic Library Online (Scielo). A busca foi realizada em outubro de 2022. Os descritores em Ciências da Saúde (DeCS) foram: esteroides anabolizantes androgênicos, anabolizantes, riscos, malefícios, efeito adverso, adultos e seus correspondentes em inglês, com as combinações dos operadores booleanos AND e OR. Os critérios de inclusão foram: publicações em português e inglês, estudos originais, de livre acesso, disponibilizados na íntegra e publicados entre 2017 e 2022. Resultados: Após a aplicação dos critérios de inclusão e exclusão, foram selecionados 18 estudos. Os principais achados foram: comprometimento do sistema nervoso central, alterações cognitivas e comportamentais, redução na densidade de neurônios da base e no hipocampo, hipertensão, insuficiência cardíaca e renal, hepatotoxicidade e alterações endócrinas- efeitos masculinizastes em mulheres. Considerações finais: Mediante as categorias elencadas no estudo foi possível evidenciar várias alterações que podem comprometer a fisiologia corporal em adultos. Realçamos a importância de conscientização dos profissionais de saúde e população em geral (principalmente praticantes de musculação), para os riscos à saúde e sua toxicidade.
Hubungan Pengetahuan, Sikap dan Perilaku Orang Tua terhadap Pemberian Vaksin Merdeka Anak
Authors: Naim Rosani , Saputri Ekawati
Published: August 2023

Saat ini, target pemerintah memberikan vaksinasi COVID-19 pada anak usia 6-11 tahun yang dimulai sejak 14 Desember 2021 dengan jumlah sasaran vaksinasi mencapai 26,5 juta anak. Pemberian vaksinasi COVID-19 pada anak sebanyak 2 kali dengan interval minimal 28 hari menggunakan vaksin Covid -19 Bio Farma dan/atau Coronavac. Pemberian vaksin pada anak telah diberikan sebelumnya yaitu pada anak usia 12-17 tahun. Tujuan: Untuk menganalisis hubungan pengetahuan, sikap dan perilaku orang tua terhadap pemberian vaksin merdeka anak. Metode: Penelitian deskripsi analitik dengan pendekatan cross sectional study. Teknik pengambilan sampel mennggunakan teknik purposive sampling dengan jumlah sampel sebanyak 171 orang. Hasil: Tidak ada hubungan pengetahuan orang tua (p value = 0,282) dan sikap orang tua (p value = 0,459) terhadap pemberian vaksin merdeka anak. Ada hubungan perilaku orang tua (p value = 0,000) terhadap pemberian vaksin merdeka anak. Simpulan: Pengetahuan dan sikap orang tua tidak memberikan pengaruh terhadap minat memvaksinasi anak sebab orang tua meyakini bahwa vaksin COVID-19 sangat penting untuk mencegah anak terkena risiko yang berat akibat COVID-19. Informasi tentang vaksin COVID-19 juga sangat penting bagi orang tua untuk mengurangi kekhawatiran terhadap efek samping dan keamanan vaksin. Diharapkan, pemerintah dalam hal ini sekolah, dokter dan perawat agar selalu mensosialisasikan vaksin COVID-19 pada anak.
Systematic Comparison of Experimental Crystallographic Geometries and Gas-Phase Computed Conformers for Torsion Preferences
Authors: Folmsbee Dakota , Koes David , Hutchison Geoffrey
Published: August 2023

We have performed exhaustive torsion sampling on more than 3 million compounds using the GFN2 method and performed a comparison of experimental crystallographic and gas-phase conformers. Many conformer sampling methods derive torsional angle distributions from experimental crystallographic data, limiting the torsion preferences to molecules that must be stable, synthetically accessible, and able to be crystallized. In this work, we evaluate the differences in torsional preferences of experimental crystallographic geometries and gas-phase computed conformers from a broad selection of compounds to determine whether torsional angle distributions obtained from semi-empirical methods are suitable for conformer sampling. We find that differences in torsion preferences can be mostly attributed to a lack of available experimental crystallographic data, with some deviations derived from gas-phase geometry differences. GFN2 demonstrates the ability to provide accurate and reliable torsional preferences that can provide a basis for new methods free from limitations of experimental data collection. We provide Gaussian-based fits and sampling distributions suitable for torsion sampling, and propose an alternative to ETKDG using quantum-torsion derived distance geometry methods (QTDG).
Understanding the effects of transition metal intercalation on electronic and electrochemical properties of Ti3C2Tx MXene
Authors: Wee Shianlin , Lian Xiliang , Vorobyeva Evgeniya , Tayal Akhil , Roddatis Vladimir , Mattina Fabio La , Vazquez Dario Gomez , Shpigel Netanel , Salanne Mathieu , Lukatskaya Maria R.
Published: August 2023

MXenes are 2D transition metal carbides, nitrides, and/or carbonitrides, capable of intercalation by various cations through chemical or electrochemical means. Previous research has primarily focused on intercalating alkaline and alkaline earth cations, such as Li+, K+, Na+, Mg2+ or alkylammonium cations, into Ti3C2Tx MXenes. However, the impact of intercalated transition metal (TM) ions on the electronic and electrochemical properties of MXenes remains largely unexplored. In this study, we investigated the effects of pre-intercalated Cu ions on Ti3C2Tx MXenes and vice versa to gain a comprehensive understanding of how the electronic and electrochemical properties of both intercalated TM ion and MXene host are altered. Using in-situ X-ray absorption spectroscopy (XAS), we reveal changes in the oxidation states of intercalated Cu ions and Ti atoms during charging and their corresponding role in charge storage mechanisms. Our findings show that electronic coupling between Ti3C2Tx and Cu ions results in modified electrochemical and electronic properties compared to pristine Ti3C2Tx. These insights lay the foundation for the rational design and utilization of TM ion intercalants to tailor the properties of MXenes for various electrochemical systems and beyond.
Accurate quantum chemical reaction energies for lithium-mediated electrolyte decomposition and evaluation of density functional approximations
Authors: Debnath Sibali , Neufeld Verena A. , Jacobson Leif D. , Rudshteyn Benjamin , Weber John L. , Berkelbach Timothy C. , Friesner Richard A.
Published: August 2023

An important concern related to the performance of Li ion batteries is the formation of the solid electrolyte interphase on the surface of the anode. This film is formed from the decomposition of electrolytes and can have important effects on stability and performance. Here, we evaluate the decomposition pathway of ethylene carbonate and related organic electrolyte molecules using a series of density functional approximations and correlated wavefunction (WF) methods, including coupled-cluster theory with single, double, and perturbative triple excitations [CCSD(T)] and auxiliary field quantum Monte Carlo (AFQMC). We find that the transition state barrier associated with ring opening varies widely across different functionals, ranging from 3.00 to 17.15 kcal/mol, which can be compared to the value of 12.84 kcal/mol predicted by CCSD(T).This large variation underscores the importance of benchmarking against accurate WF methods. A performance comparison of all the density functionals used in this study reveals that dispersion-corrected M06-2X (a meta-hybrid GGA), CAMB3LYP (a range-separated hybrid) and B2GP-PLYP (a double-hybrid) perform the best, with average errors of about 1.60 kcal/mol compared to CCSD(T). We also compared the performance of WF methods that are more scalable than CCSD(T), finding that DLPNO-CCSD(T) and phaseless AFQMC with a DFT trial wavefunction exhibit average errors of 1.38 kcal/mol and 1.74 kcal/mol respectively.
A larger basis set describes atomization energy core-valence correction better than a higher-order coupled-cluster method
Authors: Chamkin Aleksandr , Chamkina Elena
Published: August 2023

The accuracy of coupled-cluster methods for the computation of core-valence correction to atomization energy was assessed. Truncation levels up to CCSDTQP were considered together with (aug-)cc-pwCVnZ (n = D, T, Q, 5) basis sets and three different extrapolation techniques (canonical and flexible Helgaker formula and Riemann zeta function extrapolation). With the exception of CCSD, a more accurate correction can be obtained from a larger basis set with a lower-level coupled-cluster method, and not vice versa. For the CCSD(T) level, it also implies faster computations with modern codes. We also discussed the importance of moving to higher-order or all-electron methods for geometry optimizations. The present study provides the general knowledge needed for the most accurate state-of-the-art computations.
Test Deposit; Please Ignore [v3 prod]
Authors:   , Atkins Ori
Published: August 2023

Testing new prod
Religion, Politics, and Society: The Role of Political Islam in the Sudanese Revolution of December 2018 and Its Aftermath
Authors: Nur Bakheit Mohammed
Published: August 2023

December 2018 marked a new direction in Sudan’s political landscape as thousands of people revolted against President Omar al-Bashir and the Islamist regime that had ruled the country since 1989. Under authoritarian rule, Sudan suffered from genocide, war crimes, human rights violations and economic stagnation. As a result, Sudanese opposition groups organised demonstrations in 2018 to protest repression and demand change. This revolution galvanised unprecedented support from a wide variety of socio-cultural groups across the country. Protestors together with the army succeeded in ousting President al-Bashir from power in April 2019, setting in motion a process for political change in Sudan. This article analyses the practices performed by protestors in 2018 and 2019 and examines the social-cultural, political and religious dimensions of the Sudanese revolution. It also explores how the revolution’s protagonists contested the role of political Islam and how its antagonists reaffirmed their Islamo-political ideology in counter-revolutionary activities. The discussion also includes a violent atmosphere of the current war, which erupted in April 2023.
Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness
Authors: Alan Meltem , Yüksel Tuğba Nurcan , Topcu Birol
Published: August 2023

The aim of this study is to determine the effect of using atypical antipsychotic drug usage at therapeutic doses on daytime sleepiness. One hundred twenty volunteers who met the inclusion-exclusion criteria were divided into two equal groups. Group 1: patient group (60 patients volunteers used atypical antipsychotic in therapeutic doses and hospitalized in the psychiatry clinic of Tekirdağ Namık Kemal University Hospital and Group 2: control group (60 control volunteers). Socio-demographic and Clinical Information Form consist of 14 questions was administration all volunteers. Also, Epworth Sleepiness Scale which is a survey that determines the degree of sleepiness in eight different situations during the day was administered to all volunteers. Atypical antipsychotic drug usage at therapeutic doses significantly increased patients’ daytime sleepiness compared to the control group. Among the atypical antipsychotic drugs usage in therapeutic dose, the drug that caused the most daytime sleepiness was clozapine. Also, using of atypical antipsychotic drugs in therapeutic doses markedly decreased patients’ life quality compared to the control group. Atypical antipsychotic drug usage at therapeutic doses could cause daytime sleepiness and reduce patients’ quality of life.
The role of PCD in sexual dimorphism of dioecious Spinacia oleracea L.
Authors: Aytürk Özlem , Mutlu Özal , Karadeniz Pekgöz Asuman
Published: August 2023

The formation of non-hermaphroditic, i.e. male or female, flowers is a rare event in the plant kingdom. S. oleracea provides an ideal unisexual floral developmental system for studying the structural development of floral organs. These species forms non-hermaphroditic flowers; the pistil is fertile in the female flower, but the development of the stamens stops at an early phase and this organ atrophies and becomes functionless, while the male flowers form four fertile stamens, however there is not any trace of the pistil, it aborts at a much early stage. We searched for the presence of programmed cell death (PCD) in the abortive tissues during the ontogenetic development of these flowers. These results show curicial information on how the fertile sex organ in spinach differentiates and develops while arresting the development of the other aborted sex organ ; the presence of PCD occur in unisexual flower development in rhe very early stage and continue short time. We also found that stamen development in the female flower and pistil development in the male flower were subject to changes that did not result in large-scale structural changes. The PCD data obtained are the first study of spinach in the literature. This type of studies are shedding additional light on the sexual specialization hypothesis. Moreover, the ability to manipulate or control the flowering of the dioecious plant by simple means holds great potential, both from an economic aspect and to increase food production for an ever-growing human population
Bridging Molecular Docking to Molecular Dynamics to Enlighten Recognition Processes of Tailored D-A/D-A-D Types' AIEgens with HSA/BSA
Authors: Nalçakan Harun , Kurtay Gülbin
Published: August 2023

Fluorescence imaging-assisted photodynamic therapy (PDT) allows accurate tumor visualization and potentially prevents long-term side effects of cancer. Therefore, the development of photosensitizers emitting light, particularly in the near-infrared region (NIR), is essential for enhancing the efficacy of cancer therapy. On this premise, the formation of a stabilized complex between an organic dye and a target macromolecule improves fluorescence efficiency. In this scope, we performed a detailed molecular dock-ing study of Donor (D)-Acceptor (A) or D-A-D type luminogens with two blood proteins; namely bovine serum albumin (BSA) and human serum albumin (HSA), which appeared as robust carriers of several pharmaceuticals against preliminary cancer diseases. Our results revealed that the binding scores of the Dn-An or Dn-An-Dn:BSA complexes ranged from -8.5 to -11.7 kcal/mol while Dn-An or Dn-An-Dn:HSA complexes showed scores varying from -8.4 to -10.5 kcal/mol. Subsequently, molecular dynamics simu-lations were also performed for the best-docked ligands: macromolecule complexes; namely D1A1D1:BSA and D1A1:HSA, to enlighten various structural parameters. Based on the predicted root-mean-square deviation (RMSD) values (on average), the D1A1D1:BSA complex was found to be 0.319 nm, while the D1A1:HSA complex was determined as 0.284 nm. In addition, the root-mean-square fluctuations (RMSF) analyses (on average) revealed that D1A1D1:BSA (0.152 nm) was slightly more flexible than D1A1:HSA (0.160 nm).
Aktif Tektonik Rejim İçerisinde, Çanakkale Boğazı: Tenkit ve Derleme
Authors: Komut Tolga , Önder Şebnem , Özcan Ebru
Published: August 2023

Aktif tektonik rejimin faylarının çalışılması Çanakkale Boğazı bölgesi gibi mühendislik yapı faaliyetlerinin hızlandırıldığı yerlerde yapılması elzem olan sismik tehlike tetkikinde, en temel bilgiyi sağlar. Boğaz çevre-sinde, sağ yanal hareketler hâkim olup çoğu Avrasya levha sınırında gerisi de Anadolu’nun içerisindedir. Bunların arasındaki çalışma bölgesindeyse, depremsellik ve jeodetik hareketler göze çarpmaz. Kıyılarında-ki denizel taraça yükselimlerinin de tektonik değil jeodinamik hareketlerle ilgili olduğu anlaşılmaktadır. Bu çalışmada deniz sismiği araştırmalarına dayandırılan, birbirleriyle çelişkili, farklı disiplinlerdeki görüşlerle tutarsız fay modellerinin incelemesi ve bunların tenkit ve değerlendirilmesi yapılmış olup bu gibi karma-şıklaşmış durumların giderilmesi için gerektiğinde eleştirilerle geliştirilmesine uygun örnek bir usul tatbik edilmiştir. Bazı fay önerileri için destekleyici sismik kesit sunulmamış olup bazıları için ise literatürdeki diğer çalışmalarda dahî kesit bulunmaz. Deformasyonların yüzeye ulaştığı vurgusu ile önerilenler nadirdir. Bunların bir kısmını kesen kesitlerde izlenen yüzeye yakın çökellerde, deformasyon görülememektedir. Diğerleri ise erozyonal bölgeler içerdiği için belirsizdir. Her diri fay gençtir fakat her genç fay diri değildir. Nitekim, Marmara Fayı çok gençtir (200 ka civarında). Boğazın keskin morfolojisi, sıkça rastlandığı gibi paleo-tektonik rejimlere ait fayların zayıflık zonlarının drenaj sistemini kanalize etmesi ile ilgili olabilir. Geçmişteki yaygın bir sıkışma rejimi, geniş bir fay ağının gelişmesine sebep olmuştur. Fakat eldeki verilere göre, boğazdan kaynaklanan tehlikeli deprem beklentisi hasıl olmamalıdır.
Optimization of Mucilage Removal from Cress Seeds (L. sativum)
Authors: Türker İzzet , İşleroğlu Hilal
Published: August 2023

In this study, optimum removal conditions of the cress seed mucilage by a chemical method were deter-mined. Moreover, proximate analysis (moisture, fat, protein, ash and total carbohydrate) of the cress seed was carried out. The independent process variables were sodium bicarbonate concentration (0-0.5 M), solvent-to-seeds ratio (25-75 ml/g) and soaking time (3-9 hours). A central composite design having 24 points for given independent variables was used and the optimization of the process conditions was done by desirability function approach. The results showed that proximate analysis results of the cress seed were in accordance with the previous reports in literature, and fat and protein percentage was found to be higher than 20%. The mucilage removal study results showed that higher concentrations of sodium bicar-bonate enhanced the mucilage removal. Also, higher soaking times increased the solubility of the seed coat polysaccharides of the cress seeds, resulting in better mucilage removal. The optimum chemical mucilage removal conditions were determined as 0.43 M sodium bicarbonate, solvent-to-seeds ratio of 75 ml/g and 8.96 hours of soaking time. At these conditions, total carbohydrate (determined using Anthrone method) in the final extract was predicted as 2.47 g/ml. Verification tests were carried out at the optimum conditions and there was no statistical difference between experimental (2.64±0.43 mg/ml) and predicted values.
Improving End-Point Position Control in Hydraulic Testing Machines with a Fuzzy Logic Based Approach
Authors: Anlak Serkan , Düven Ekrem
Published: August 2023

During the repetitive operation of hydraulic testing machines, some undesirable vibration movements and non-compliance with the set value may occur at the piston end-point, which is the output of the system. PID (Proportional-Integral-Derivative) control is widely used in such systems in practical applications. However, the use of a standard (fixed coefficient) PID control alone cannot completely eliminate problems such as endpoint vibration and/or non-compliance of the endpoint position with the set value, caused by dynamic parameter changes in the hydraulic system. In the current state of the applications, when such a situation is encountered, the controller coefficients need to be readjusted by a human operator. In this study, to avoid this need and automatically adjust PID controller coefficients, a fuzzy logic-based computation approach has been developed and applied to the existing control system. A hydraulic system was designed and realized to test the developed method. The end-point position control of the system was established and improved utilizing the developed approach. With this development, an improvement of more than 10% was achieved in the adjustment of the hydraulic testing machine end-point oscillation amplitude to the set value. The use of this method also eliminates the need for human operators to readjust the controller parameters in case of long-term operation of hydraulic test systems.
Colchicine is an effective therapeutic agent in erosive hand osteoarthritis
Authors: Ertürk Adem , Sarı Alper
Published: August 2023

Background/Aim: The efficacy of colchicine has been assessed in hand osteoarthritis; however, no studies have investigated its use in the more severe subtype of hand osteoarthritis, known as erosive hand osteoarthritis (EHOA). This retrospective cohort study investigated whether colchicine therapy could provide symptomatic relief and improve inflammation markers in patients with EHOA.
Methods: The study included a total of 43 EHOA patients using colchicine (2×0.5 mg) + paracetamol (3×500 mg) daily (colchicine group) and 43 EHOA patients using only paracetamol (3×500 mg) (standard therapy group). Both groups were evaluated for various parameters.
Results: The groups were similar in terms of age, sex distribution, and other sociodemographic variables. The decreases in erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels from baseline were significantly greater in the colchicine group (P<0.001). Additionally, the visual analog scale (VAS) and Australian Canadian Osteoarthritis Hand Index (AUSCAN) scores, which include pain, stiffness, function, and total score, were significantly better in the colchicine group at 3 months compared to the standard therapy group (P<0.001). Furthermore, although both groups showed significant improvements in these parameters, the amount of improvement was significantly greater in the colchicine group (P<0.001).
Conclusion: The combined use of colchicine and paracetamol improved CRP and ESR levels, VAS score, and all AUSCAN scores in patients with EHOA. Moreover, these benefits were significantly greater than standard therapy with paracetamol alone. Colchicine appears to be an effective therapeutic agent in the treatment of EHOA.
Climate Forecasting Models for Precise Management Using Extreme Value Theory
Authors: Guayjarernpanishk Pannarat , Chiangpradit Monchaya , Kong-ied Butsakorn , Chutiman Nipaporn
Published: August 2023

The objective of this research was to develop a mathematical and statistical model for long-term prediction. The Extreme Value Theory (EVT) was applied to analyze the appropriate distribution model by using the peak-over-threshold approach with Generalized Pareto Distribution (GPD) to predict daily extreme precipitation and extreme temperatures in eight provinces located in the upper northeastern region of Thailand. Generally, each province has only 1–2 meteorological stations, so spatial analysis cannot be performed comprehensively. Therefore, the reanalysis data were obtained from the NOAA Physical Sciences Laboratory. The precipitation data were used for spatial analysis at the level of 25 square kilometers, which comprises 71 grid points, whereas the temperature data were used for spatial analysis at the level of 50 square kilometers, which includes 19 grid points. According to the analysis results, GPD was appropriate for the goodness of fit test with Kolmogorov-Smirnov Statistics (KS Test) according to the estimation for the return level in the annual return periods of 2 years, 5 years, 10 years, 25 years, 50 years, and 100 years, indicating the areas with daily extreme precipitation and extreme temperatures. The analysis results would be useful for supplementing decision-making in planning to cope with risk areas as well as in effective planning for resources and prevention. Doi: 10.28991/CEJ-2023-09-07-014 Full Text: PDF
Experimental and Analytical Study on Postfire Reinforced Concrete Beams Retrofitted with CFRP in Flexure and Shear
Authors: Nguyen Vu Nguyen , Cao Vui Van
Published: August 2023

In this study, experiments were performed on carbon fiber reinforced polymer (CFRP) retrofitted postfire reinforced concrete (RC) beams, followed by theoretical analyzes. Experiments were conducted on eleven RC beams, which were exposed to different fire durations and retrofitted with CFRP in flexure and shear. The experimental results indicated that fire shifted the flexure failure to the flexure-shear failure of postfire RC beams. CFRP retrofitted postfire RC beams experienced progressive peeling-off failure. FRP retrofitting significantly increased the yield deflection by 58.2−97.3% but decreased the ultimate deflection by 43.0−55.5% compared with that of the control beam. Consequently, the ductility was reduced by 69.7−74.7%, categorized as low ductility. CFRP retrofitting successfully increased the strengths of 30-min postfire beams by up to 23.1% higher than those of the control beam. Fire significantly decreased the stiffness of postfire beams by 46.4−49.2% compared with that of the control beam, whereas CFRP retrofitting did not fully recover the stiffness of postfire beams. Finally, a simple model of the moment capacity of postfire beams without/with CFRP retrofits was developed based on the practicability of limited data feasibly obtained from real fires. The proposed model, with its simplicity, practicability, and reasonable accuracy, can be a useful tool for structural engineers in the FRP retrofitting of postfire RC structures. Doi: 10.28991/CEJ-2023-09-07-05 Full Text: PDF