bluuebunny/crossref_metadata_2025 huggingface dataset:
Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
Authors: Castedo Maria , Lafarge Antoine , Kroemer Guido
Published: January 2023

The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhibition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.
METASTATIC NEUROENDOCRINE TUMOR OF THE OVARY - AN UNUSUAL SITE
Authors: Parikh Ratna , Parikh Anuj , Arneja Sarabjeetkaur , Desai Praful
Published: January 2023

A 22 year old female with stage III small cell neuroendocrine carcinoma of the lung presented two years later with a large abdomino-pelvic mass. Core biopsy showed a metastatic high-grade neuroendocrine carcinoma. She responded poorly to chemotherapy. An exploratory laparotomy revealed bilateral large ovarian masses. Total hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathology showed a metastatic high grade neuroendocrine carcinoma of both ovaries, consistent with metastasis from small cell neuroendocrine carcinoma of the lung. Post adjuvant chemotherapy she remained controlled over four years. We present a rare case of small cell neuroendocrine tumor of the lung with metastasis to the ovary.
Zinc fertilizer : Potent public health intervention under COVID-19
Authors: Dogra Prerna , Kumawat Chiranjeev , Omprakash  , Parashar Aabha , Parashar Kamini
Published: January 2023

Corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) represents the biggest current health challenge for the society. At the moment, the therapeutic strategies to deal with this disease are only supportive. It is well evident that zinc (Zn) possesses a variety of direct and indirect antiviral properties, which are realized through different studies during the course of time. Administration of Zn supplement has a potential to enhance antiviral immunity, both innate and humoral, and to restore depleted immune cell function or to improve normal immune cell function, particular in immune-compromised or elderly patients.In recent years, the increasing zinc (Zn) deficiency problem has garnered attention and appears to be the most serious micronutrient deficiency along with vitamin A deficiency. The concentration of Zn in cereal crops is inherently very low and growing cereals on potentially Zn-deficient soils further decreases grain Zn concentrations. It is, therefore, not surprising that high Zn deficiency in humans occurs predominantly on areas where soils are deficient in plant-available Zn. Biofortification (enrichment) of crops with Zn and breeding new cereal genotypes for high grain Zn concentration is the most realistic and cost-effective strategy to address this problem. However, this strategy is a long-term one, and the size of plant-available Zn pools in soils may greatly affect the capacity of Zn-efficient (biofortified) cultivars to take up Zn and accumulate it in grains. Therefore, application of Zn-containing fertilizers represents a quick and effective approach to biofortify cereal grains with Zn. It is obvious that enrichment of widely applied fertilizers with Zn and/or foliar application of Zn fertilizers appear to be a high priority with the strongest potential to alleviate Zn deficiency-related problems in India. A Government action and policy plan for enrichment of selected major fertilizers with Zn is required urgently.
Assessment of influencing determinants on maternal health and wellness: A descriptive research study
Authors: Dave Rashmi , Vyas Jiju N. , Tiwari Neha
Published: January 2023

Maternal nutrition and health during pregnancy has been associated with healthy outcomes for both mother and child. This study investigated the factors influencing the nutritional and health practices of pregnant women attending regular diagnosis and treatment at Government Hospitals in Ahmedabad. A Study employed a descriptive, non-experimental research design. Personal Interview technique was used for data collection at Government Hospitals. Sample of 150 Pregnant women was selected from the hospitals. Non Probability Convenience Sampling Method was used. SPSS version 20.0 was used to analyze the collected data. Multiple regression technique was applied to understand holistic effect of all the determinants of maternal nutrition and health.
Educational aspiration of high school children from single parent families
Authors: Matti Sushmita B. , Itagi Sunanda , Matti Shreela B.
Published: January 2023

The recent increase in single parent families affecting the educational aspiration among children. The present paper examines the educational aspiration of high school children from single parent families of Dharwad taluk which was conducted during 2019-2020. A total of 240 children were selected from urban (n=120) and rural (n=120) areas of Dharwad taluk through purposive sampling technique. A self structured questionnaire was used to collect the demographic characteristics of children. Mazumdar Educational Aspiration Inventory (2004) was used to assess the educational aspiration among children. Socio-economic status scale by Aggarwal et al. (2005) was used to measure the socioeconomic status of children. The study outcomes highlighted that, educational aspiration was significantly associated with locality of children. Urban children had high educational ambitions than rural children. Gender was associated significantly with educational ambitions in both areas. Age was not associated significantly with children in both the areas. Girls had high aspirations than boys in both urban and rural areas. Ordinal position was not associated significantly with educational aspiration of children in both areas. Study further showed that children residing status was associated significantly with educational ambitions of children in both regions indicating that children residing with their mothers had high educational aspirations than their counterparts. Socio-economic status showed significant difference with educational ambitions of children in both the regions which points out that children with poor socio-economic status had low educational aspiration than children with upper socio-economic status. The study showed that nearly 24 percent of children need intervention programme to improve their educational attainment and ambitions.
Studies on interrelationship and path co-efficient analysis on the basis of fruit yield in eggplant (Solanum melongena L.)
Authors: Ram Kailash , Singh P.
Published: January 2023

The genotypic and phenotypic correlation and path co-efficient in nineteen genetically diverse genotypes of eggplant were studied at Vegetable Research Station (C S Azad University and Technology, Kanpur) during Kharif season. Studies on relationship at genotypic level revealed positive and strong correlation of yield per plant, number of branches per plant, width of fruit, plant spread and fruit weight in parents, F1s and F2s, whereas significant and positive association of yield per plant with number of fruits per plant were observed in parents, F1s and F2s at phenotypic level. Path coefficient analysis indicate that number of fruits per plant had highest direct/desirable effect on yield per plant followed by fruit weight in both F1 and F2 at genotypic and phenotypic level and days to flowering in F1 and F2 only at genotypic level. The highest positive direct effect on yield per plant was observed by most of the yield contributing characters, i. e., days to marketable maturity and number of branches per plant via number of fruits per plant, length of fruit and width of fruit, and plant spread via number of fruits per plant in F1 and F2 generations at both genotypic and phenotypic levels.
Influence of integrated nutrient application based on STCR approach on nutrient uptake of rice under ricemaize cropping sequence
Authors: Pandey Amit Kumar , Singh Ashutosh , Singh Umesh
Published: January 2023

Soil testing helps the farmers to use fertilizers according to need of crops. Fertilizer use for targeted yield is an approach which take into account the crop need and nutrient present in the soil. A study on soil test crop response based integrated plant nutrient ion system (STCR) were conducted adopting targeted yield method in non-calcareous sandy loam soil of Ustifluvents at Mandan Bharti Agriculture College, Agwanpur, Saharsa during the two consecutive of 2018 and 2019. The experiment was laid out in RBD with nine treatments replicated thrice. The STCR approach with or without FYM at low, medium and high target yield markedly increase the yield and uptake of NPK of rice. Thus, the targeted yield model used to develop fertilizer precipitation equations provides a strong basis of soil fertility maintenance consistent with high productivity and efficient nutrient management for sustainable and enduring agriculture. This also improved the relationship between farmers and scientists and built confidence between them.
Studies on correlation and path co-efficient analysis of single cross hybrids in sweet corn
Authors: Praveena M. Vani , Talekar S. C. , Kachapur R. M.
Published: January 2023

A total of 42 experimental hybrids generated by diallel mating design using 7 inbred lines of sweet corn were evaluated with parents and checks during Kharif 2019 at University of Agricultural Sciences, Dharwad. Green ear yield revealed a significant correlation in the positive direction with plant height, ear height, ear length, ear girth, number of kernel rows, and number of kernels per row at both genotypic and phenotypic levels, while a negative correlation was observed with days to 50% silking and Turcicum Leaf Blight. The highest value of correlation co-efficient for green ear yield was observed with green ear yield without husk, followed by the number of kernels per row and ear girth. However, there is no significant correlation between green ear yield and Total Soluble Solids. The genotypic correlation was found to be higher than the phenotypic correlation indicating high heritability of traits. Ear girth, ear height and the number of kernels per row displayed the highest positive direct effects on yield at the genotypic level and also manifested significantly positive indirect effects via plant height, ear height, green ear weight without husk, green fodder weight and the number of kernels per row. These three traits were likewise shown to have the most positive correlation with green ear yield. As a result, these attributes can be considered while selecting sweet corn genotypes for higher green ear yield.
EN PRENSA. Prácticas culturales e importancia del componente florístico-pecuario en agroecosistemas de Atzalan, Xochiapulco, Puebla. EN PRENSA
Authors: UGALDE LEZAMA SAUL , Romero-Díaz Claudio , Valdes-Velarde Eduardo , Tarango-Arambula Luis Antonio
Published: January 2023

El componente florístico-pecuario que integra a los agroecosistemas en Unidades de Producción Familiar (UPF) fomenta la riqueza sociocultural. Se identificó el valor de importancia cultural florístico-pecuario mediante la caracterización, para proponer buenas prácticas de manejo productivo. Para ello de octubre de 2021 a enero de 2022 se aplicaron entrevistas semiestructuradas y recorridos de campo. Se caracterizaron las UPF, prácticas-culturales, rendimiento, precios de venta, tipo de uso, arreglo-distribución espacial y variables físico-ambientales. Asimismo, se detectaron ingresos económicos externos que contribuyen a la economía familiar. Se aplicó índice de importancia cultural (IC), análisis de componentes principales (ACP), Kruskal-Wallis, prueba Tukey y diagrama de Hart. Se registraron dos tipos de agroecosistema, con una pendiente que varió entre 5 y 35 % y temperatura ambiental mínima-máxima de 21.2 °C y 26.3 °C, respectivamente. Las UPF se integraron en mayor porcentaje por adultos mayores con primaria inconclusa. El cultivo de milpa (maíz-frijol-calabaza) tuvo un rendimiento promedio de 244.5 kg de maíz y 33.5 kg de frijol. Se registraron 97 especies florísticas útiles y 14 usos de las mismas. El arreglo florístico espacial fue aleatorio, uniforme y semi-uniforme. El IC florístico-pecuario registró valores altos para: Persea americana (4.5), Phaseolus vulgaris (3.0), Prunus pérsica (3.7) y Zea mays (4.3); pollos (2.3), guajolotes (0.9), patos (0.9) y cerdos (0.9), respectivamente. El ACP florístico-pecuario mostró mayor correlación como: soporte vivo, obtención de frutos y leña; obtención de carne, huevos, como obsequio, cría y abono. A pesar de los problemas económico-migratorios del área evaluada aún preserva el uso cultural florístico-pecuario.
Features of self-esteem in anxious children of senior preschool age
Authors: Nikolaeva Irina , Vershinina Valeria , Silakova Marina
Published: January 2023

The work is aimed at studying the manifestation of self-esteem in anxious children of older preschool age. The materials of an empirical study obtained on a sample of children of senior preschool age from kindergartens in Ulyanovsk are presented. The study involved children aged 6,5 to 7 years. The study included psychological diagnostics using the following methods: “The Train Engine Method” (Velieva S.V.), the method for identifying children's fears by A.I. Zakharov and M.A. Panfilova “Fears in houses”, Test “Fairy tale” (L. Duss), Method “Ladder” V.G. Schur. The results obtained make it possible to say that among the sample of children of older preschool age, signs of anxiety in one form or another were detected in 40 % of the subjects. Anxiety manifests itself both in a general negative emotional state and in the presence of certain fears. The most prominent are the fear of loneliness and the fear of punishment from parents. In anxious children, inflated self-esteem is less common than in children who are not prone to anxiety. In children with a normal level of anxiety, their own assessment of themselves is higher than the assessments of others (mother and teacher). In anxious children, the situation is reversed, they tend to evaluate themselves lower than the surrounding adults. One of the hypotheses of such results of the study is that the increased level of anxiety and fears in children of older preschool age may be the result of a strict and critical attitude towards them from their parents. In general, the study is intended to prove the fact that the structure of self-esteem in anxious children is characterized by inadequate perceptions of themselves and their achievements (the cognitive component of self-esteem) and low self-satisfaction.
Development and application of nanocatalysts for processing synthesis gas into methanol
Authors: Chekushina Tatiana , Lianzi Zhang , Vorobyev Kirill
Published: January 2023

This article presents a study on the development and improvement of nanoscale heterogeneous nanocatalysts based on copper and zinc oxide for the subsequent processing of synthesis gas into methanol. An analytical review of modern types of nanocatalysts is presented, general information about the types of nanocatalysts for methanol production is provided, a patent search is performed, methodological approaches to the development of new and improvement of existing nanocatalysts are substantiated. The results of laboratory studies related to the creation of structures of new types of nanocatalysts are presented, their optimal composition is justified and computer modeling using the "Material Studio" program is carried out. Modifications of nanocatalyst matrices, promoters, and Cu/Zn ratios in catalysts have been investigated. The mechanism of chemical reactions occurring on the surface of metal nanoparticles during the production of methanol from synthesis gas is described, the process of adsorption of CO on the surface of copper nanoparticles is modeled, the process of separation and production of methanol is shown, the activation energy of the chemical reactions occurring is calculated. Models have been developed for: nanoparticles based on Cu and ZnO; adsorption of CO on the surface of nanoparticles; addition of hydrogen to the surface of nanoparticles; production of methanol on the surface of nanoparticles with the calculation of the activation energy of chemical reactions on the surface of nanoparticles. A technological scheme for the production of methanol using a nanostructured bimetallic catalyst has been developed. It is shown that the obtained nanocatalysts based on Cu and ZnO have optimal catalytic properties for laboratory experiments.
The concept of the possibility of resettlement of compatriots in Russia
Authors: Bakanova Marina
Published: January 2023

For a long time in Russia there is a problem of not so much a decrease in the total population, but a deterioration in its quality. In particular, this is due to the problem of brain drain (brain drain), which began massively in the 90s. At the beginning of the 21st century, attempts began to address this issue, including — since 2007, a program of return resettlement of compatriots was launched. Currently, it places a certain emphasis on the resettlement of precisely “talented compatriots”, however, there are no real results. The main problems of resettlement are: finding a job, housing, studying children and partly — difficulties in obtaining citizenship. In this paper, an attempt was made to find out the occurrence of difficulties in finding a workplace, since in fact “talented people are needed by everyone” and conclusions were drawn about the real complexity of integrating into the Russian reality of a talented person from abroad.
Methodology for the formation of a motivational-stimulating factor in teaching a professionally oriented foreign language
Authors: Liakhova Elena , Frolova Olga , Lopatinskaya Victoria
Published: January 2023

The article is devoted to the problem of developing positive motivation in the process of teaching a professionally oriented foreign language as a necessary condition for the formation of a foreign language professional communicative competence. The analysis of a number of psychological and pedagogical works on the issues of influence of personal motivation on the success of foreign language mastering is presented. The authors analyze aspects and different types of motivation in teaching a foreign language, with special attention paid to the relationship between cognitive and professional motivation in teaching a professionally-oriented foreign language; they give a comparative assessment of traditional foreign language teaching and modern innovative methods and approaches in terms of maintaining a high level of motivation of students. The advisability of implementing context-based approach elements such as role-playing and business games, as well as active listening, one of the main methods of coaching, in order to increase motivation when teaching a professionally-oriented foreign language is justified. The article describes experimental work on increasing the motivation level when teaching a professionally-oriented foreign language to future specialists in the field of tourism and hospitality using a system of emotional and intellectual stimulation and the active listening method within the context-based approach, it provides examples of tasks and exercises to form active listening skills in professionally-oriented role-plays and business games. The authors present a quantitative and qualitative analysis of empirical data of the experimental work aimed at improving the motivation level with the help of the above methods; they describe the results of the experimental work, which reflect the effectiveness of the training course with the elements of active listening, expressed in the positive dynamics of growth in integrative professional motivation level as a result of teaching professionally-oriented foreign language.
Aspects of the formation of multicultural competence in quality management
Authors: Orlova Yuliya , Repina Irina
Published: January 2023

Russia is a large multinational country where people with diverse cultures live and work. The article highlights the problem: against the background of the interaction of the diversity of cultures due to the insufficient level of moral consciousness and multicultural competence, unfortunately, misunderstandings arise, which leads to the separation of people for any reason: skin color, eye shape, clothing, language, a different view of the world, etc. All this is no exception in the professional sphere: conflicts between specialists, consumers, infringement of rights, unfair reduction of professional skills and abilities of worthy specialists, unequal competition, and incorrect division due to nationality. Therefore, today multicultural competence stands out as one of the components of the result of education through the formation of proper competencies in the system of vocational education in Russia. The article reveals the importance of the formation of multicultural competencies among accreditation experts. The authors reviewed the document "Standard of professional activity of accreditation experts CM No. 04.1-9.0004", identified skills that relate to the formation of multicultural competence, also analyzed the training program, which was presented on the official website of Rosaccreditation for accreditation experts for the 1st and 2nd quarter of 2022. The authors identified the problem that there are no specific specifics in the material considered and little information about multicultural skills, after which recommendations were given. The paper also reveals the importance of the activities of experts, that is, accreditation in the formation of intercultural communications between Russia and other countries: confirmation for certification bodies of interethnic competencies, ensuring the trust of other countries. The article will be of interest to specialists both in the field of conformity assessment and in the field of education.
The specifics of social resocialization of convicts sentenced to deprivation of liberty
Authors: Zyazin Sergey
Published: January 2023

The article reveals the problem of the specifics of the social resocialization of those sentenced to deprivation of liberty. The factors determining it are determined, where labor is named as the main one. This kind of approach makes it possible to evaluate other elements of the social resocialization of convicts sentenced to deprivation of liberty. In the literature, they are usually defined as equivalent. However, the analysis of their content, carried out in the article, made it possible to establish the main role of labor, above all other signs (factors).
The essence of the resocializing role of the theoretical and methodological approach, to the definition of its mechanism in achieving the goals of criminal punishment, is revealed. This allows us to establish the sequence of the resocializing impact on those sentenced to deprivation of liberty throughout all stages of the penal process (the penitentiary and post-penitentiary periods of social resocialization of convicts).
It is concluded that social resocialization determines its structure based on the attitude of the convict to work, where the latter acts as the leading element of penitentiary influence on the personality of the convict. It is summarized that the process is carried out in two stages, the first penitentiary proceeds directly in the conditions of a correctional institution, the second post-penitentiary in the conditions of a free society, where there is a kind of consolidation of those values and norms that were restored to the convict as a socialized member of a free (open) society. The social resocialization of those sentenced to deprivation of liberty is formulated by the author as a specific process that allows creating conditions under which it is possible to overcome the social alienation of the person serving (has served) a criminal sentence in a free (open) society
A PRÁTICA DA DOCÊNCIA COM O USO DE METODOLOGIAS ATIVAS DE ENSINO NA ENFERMAGEM
Authors: Mistura Claudelí , Martins Silvana Neumann , Leivas Danielle Valim Pereira
Published: January 2023

O estudo teve como objetivo analisar as evidências científicas sobre o uso de metodologias ativas de ensino na prática da docência nos cursos de Graduação em Enfermagem. Trata-se de uma Revisão Integrativa da Literatura (RIL) desenvolvida por meio de dois portais eletrônicos nacionais e três bases de dados internacionais. A realização da RIL ocorreu nos meses de fevereiro a maio de 2022. Com a aplicação dos critérios de seleção, incluíram-se 24 artigos científicos. Com a síntese do conhecimento desta RIL evidenciou-se que o uso de metodologias ativas de ensino na prática da docência, nos cursos de Graduação em Enfermagem, direciona-se para dois temas: as potencialidades e contribuições das metodologias ativas de ensino e as fragilidades e os desafios para o uso das metodologias ativas de ensino. Dentre as potencialidades e contribuições destacam-se: aproximação da teoria com a prática, desenvolvimento de competências e habilidades e autoconhecimento, relação interpessoal e relação alunos-professor. Já nas fragilidades e desafios evidenciou-se a capacitação docente; a reestruturação curricular por meio de um currículo integrado; a inclusão dos alunos nas mudanças curriculares e na aplicação das metodologias ativas durante a sua formação acadêmica. Conclui-se sobre a relevância e precisão de implementação e implantação das metodologias ativas de ensino nos cursos de Graduação em Enfermagem por meio de um currículo integrado por módulos ou unidades curriculares, tornando-se essencial a capacitação de enfermeiros/docentes.
Examples of integrating hydraulic equipment into temporary works
Authors: Ascaso Til Mercedes , Wong Wilson
Published: January 2023

This paper focuses on the integration of hydraulic equipment into temporary works and how they can work together to provide safe and effective solutions across different fields of civil engineering. The focus is on the challenges faced by temporary works designers and how to solve them by integrating hydraulics into innovative modular construction methods for structures such as high-rise buildings, airport infrastructure and sports stadia, with notable examples provided from around the world. The paper also covers high-capacity tower systems for refinery construction and various bridge construction projects, from concrete viaducts to suspension bridges.
Parigi Carbonate Reservoir for Underground Gas Storage in West Java, Indonesia
Authors: Sirodj Edison Gunawan , Sunardi Edy , Adhiperdana Billy G , Haryanto Iyan
Published: January 2023

DOI:10.17014/ijog.9.2.219-228This paper focuses on the characteristics and distribution of shallow reservoir carbonate in an underground gas storage. This study was done on Parigi carbonate as a significant reservoir carbonate in West Java Basin. The carbonate is abundant, and it occurs at shallow depths 800 to 1000 m below sea level. This formation broadly spreads out in onshore and offshore West Java areas as platform and build-up carbonates. The development of buildup carbonates is mostly in a low relief offshore. They well-developed onshore where the build-up exhibits coral reef frameworks, high relief, reaching over 450 m in thickness. The carbonate outcrop in Palimanan, western Cirebon which has been studied is grouped into four types of lithofacies. The preservation condition of this carbonate reservoir is important, for the storage capacity can inject a big gas volume. The porosity and permeability parameters are the most influential factor in reservoir evaluation. The parameters for gas storage in this field are within the range of the existing field parameters in Europe and America.
Termination and early conclusion in sexual crimes against the constitutional principle of equality in Peru
Authors: Gutiérrez Cruz Milagritos Elizabeth
Published: January 2023

The present article "Termination and early conclusion in sexual crimes against the constitutional principle of equality in Peru", has the purpose of determining if the non-applicability of these legal figures in sexual crimes in Peru complies with the constitutional parameters of equality, because by prohibiting the application of these mechanisms they transgress the constitutional principle of equality. Regarding the methodology, it has a qualitative approach; Non-experimental design, the instrument applied is the registration form, whose scenario was 7 sentences of the CSJS of termination and conclusion in the matter of acts against indecentness, and it was concluded that the non-applicability of these procedural institutions in sexual crimes does not comply with the constitutional parameters of the principle of equality, since the results indicate that according to file no. 02 in exp. N°00409-2020-9-2501-JR-PE-05 although the benefit is applied, however, the reduction of the penalty becomes effective.
Association of triglyceride/high-density lipoprotein cholesterol ratio with subclinical inflammation and 10-year cardiovascular disease risk as determined by Framingham risk scores in Korean male smokers
Authors: Seo Myung Jae , Kim Jong-Koo , Kim Ji-Hye , Chung Tae-Ha
Published: January 2023

Various risk factors and the multifactorial pathophysiology of cardiovascular disease (CVD) have been studied. We focused on the interaction between insulin resistance and inflammatory processes. Thus, we analyzed the association of triglyceride/high-density lipoprotein cholesterol (TG/HDL) ratio with subclinical inflammation and CVD risk in male smokers. We retrospectively reviewed medical records from the Health Promotion Center of Severance Hospital in Korea between 2015 and 2017. Subjects were currently smoking men aged 30 to 59, with leukocyte counts within the normal range, for a total of 1,566. We grouped participants into four groups using the median TG/HDL ratio and the median leukocyte count. The odds ratio (OR) of high Framingham 10-year CVD risk (≥10%) was calculated using multiple logistic regression. The median Framingham 10-year CVD risk increased significantly from Group 1 (low leukocyte count, low TG/HDL ratio) to Group 4 (high leukocyte count, high TG/HDL ratio). The OR for Group 4 was 2.46 compared with Group 1 after adjusting for various CVD risk factors. In subgroup analysis, the OR of the highest leukocyte group was 1.57 compared to the lowest leukocyte group after adjusting for other variables. In conclusion, TG/HDL ratio and subclinical inflammation were positively related to CVD risk in Korean male smokers.
Low-and High-Voltage Electrical Burns in Children: Ten Years of Experience
Authors: DEMİR YİĞİT Yasemin , ÖZTAŞ Tülin
Published: January 2023

Objective: Burn injuries are an important public health problem for all ages. Due to electrical burns high mortality and morbidity rates, they should be evaluated differently from burns from other sources. This study aims to determine factors associated with high-and low-voltage electrical burns in children.
Materials and Methods: The records of 72 patients who were treated for electrical burns were analysed. Electrical burns were divided into two groups: low and high voltage. Demographic data, treatment, outcomes were compared between the two groups.
Results: In this study, low-voltage electrical burns were detected in 83.3% of the patients, and high-voltage electrical burns were detected in 17.7% of the patients. High-voltage burns were more common in rural residents (p<0.05). Low-voltage electrical burns mostly occurred as a result of home accidents (90%), while high-voltage injuries were mostly caused by work accidents (100%), (p<0.05). The most common cause of low-voltage injuries was contact
with an electrical outlet (91.6%), for high-voltage injuries it was contact with a transformer (83.3%) (p<0.05). For high-voltage injuries, the severity of the burns was higher, the duration of the hospital stay was longer (p<0.05).
Conclusion: Children generally have low-voltage injuries. High-voltage injuries are associated with more surgical treatment and morbidity, longer hospital stays. Electrical burns can be reduced by training on protective measures and proper arrangement of infrastructure in rural areas
Bölgemizde Uygulanan Biontech ve Sinovac Aşılarına Karşı Gelişen Antikor Yanıtının Değerlendirilmesi
Authors: ÇEYLAN Kaan , KARSLIGİL Tekin , AŞKIN Feyza Nur , KAYA ÖZEN Gülsüm
Published: January 2023

Amaç: SARS-CoV-2’nin yol açtığı COVİD-19 pandemisi başladığı günden bugüne etkisini arttırarak, dünya genelinde milyonlarca insanı enfekte etmiş ve ciddi oranda ölümlere yol açmıştır. Halen etkili ve kesin bir tedavi ya da profilaksi yönteminin bulunamamış olması aşı çalışmalarının önemini daha çok arttırmıştır. Ülkemizde 14 Ocak 2021 tarihi itibariyle başta sağlık çalışanları olmak üzere tüm vatandaşlara CoronaVac (Sinovac) ve Pfizer-Biontech aşıları uygulanmaya başlanmıştır.
Bu çalışmada ülkemizde aktif olarak uygulanan bu iki aşının etkinlikleri değerlendirilmiştir.
Yöntem: Çalışmaya daha önce klinik, radyolojik ya da PCR yöntemlerle COVİD-19 tanısı konulmamış olan 84 gönüllü dahil edilmiştir. Gönüllülerden aşı uygulamasından önce ve ilk doz aşı uygulamasının üzerinden 1 aylık bir süre geçtikten sonra serum örnekleri alınmıştır. Alınan serum örneklerinden, Enzim Linked Immun Sorbent Assay (ELISA) yöntemiyle SARS-CoV-2 IgG düzeyleri ölçülerek, iki farklı aşının etkinlikleri açısından incelenmiştir.
Bulgular: Çalışmaya 39’u kadın, 45’i erkek olmak üzere, 84 gönüllü dahil olmuş; 50 gönüllü CoronaVac (Sinovac), 34 gönüllü ise Pfizer-Biontech aşısını tercih etmişlerdir. CoronaVac (Sinovac) aşısı uygulanan 13, Pfizer-Biontech aşısı uygulanan 4 gönüllünün aşı öncesi SARS-CoV-2 IgG antikor titreleri pozitif olarak saptanmıştır. Aşı öncesi SARS-CoV-2 IgG antikor titreleri negatif olan gönüllülerden; tek doz CoronaVac (Sinovac) aşısı uygulananlarda %67,6 (25/37), tek doz Pfizer-Biontech aşısı uygulananlarda %100 (30/30) oranında seropozitiflik tespit edilmiştir.
Sonuç: Çalışmaya katılan gönüllülerin 17'sinde (%20,2) aşı öncesi seropozitiflik saptandı. Çalışma öncesi seronegatif olan gönüllülerden; CoronaVac-Sinovac ile aşılananların %67.6'sı; Pfizer-Biontech ile aşılananların %100'ünde aşı sonrası seropozitiflik gelişmiştir. Çalışmada Pfizer-Biontech aşısının tek doz aşılamadan sonra bağışıklık sistemini daha iyi uyardığı görülüyor.
Antibiotic resistance of uropathogens in patients with nephrolithiasis and concomitant coronary heart disease
Authors: Royuk R. V. , Yarovoy S. K. , Shikina I. B.
Published: January 2023

Objective: to identify the main causative agents of chronic calculous pyelonephritis and determine their antibiotic resistance in patients with nephrolithiasis combined with coronary heart disease (CHD).

Material and methods. A retrospective case-control study included 181 patients aged 57 to 82 years old who were treated at the urological center of branch no. 1 of Burdenko Main Military Clinical Hospital in 2014–2019. All patients long-term suffered from urolithiasis complicated by chronic calculus pyelonephritis in combination with CHD. Clinically significant results of bacteriological urine examinations (CFU≥103) were analyzed. The midstream urine specimen cultivation was performed sectorally on Endo agar. The minimum suppressive concentration of the test antibacterial preparations for each of the detected microorganisms was determined by dilution on a dense Müller–Hinton agar culture medium (BBL, USA). The results were processed using the Shapiro–Wilk, Kolmogorov–Smirnov, and χ2 Pirson criteria. The values of p≤0,05 were considered as statistically significant.

Results. Specimen culturing revealed Escherichia coli – 24.8%, Klebsiella pneumoniae – 18.3%, Pseudomanas aeruginosa – 11%. Staphylococcus spp., and Enterococcus spp. were most important among gram-positive pathogens (total 26.6% of cases). The sensitivity of the detected infectious agents to basic antibacterial drugs turned out to be sharply reduced. It is noteworthy that 65% of P. aeruginosa strains were sensitive to meropenem.

Conclusion. In patients with recurrent urolithiasis combined with CHD, the proportion of gram-positive coccas was increased on the background of calculous pyelonephritis with a simultaneous decrease in the proportion of poly-resistant gram-negative infectious agents (nosocomial strains of E. coli and K. pneumoniae).
Concentration of vitamin D metabolite – 25(OH)D3 as a predictor of breast cancer progression
Authors: Frolova D. Е. , Lapochkina N. P. , Gromova О. А. , Torshin I. Yu.
Published: January 2023

Background. Prediction of breast cancer (BC) progression is important for the timely correction of patient therapy.

Objective: to assess a relationship between BC progression and degree of vitamin D deficiency.

Material and methods. A retrospective controlled study was performed. The results of examining 67 women aged 29–48 years with histologically verified BC and vitamin D deficiency are presented. All patients were divided into two groups: the main group – 34 women administered with vitamin D, comparison group – 33 patients not taking vitamin D.

Results. It was shown that 25(OH)D3 level less than 18.9 ng/ml was significantly associated with prominent disease progression, regardless of the tumor molecular subtype. Additional criteria were developed allowing to predict BC progression.

Conclusion. In order to detect secondary changes (distant metastases in ВС patients) and improve patient monitoring, it is recommended to use additional diagnostic methods and determine the intermediate metabolite of vitamin D – 25(OH)D3 in peripheral blood.
Background Causes for Criminal Liability for Bioprinting
Authors: Galyukova M. I.
Published: January 2023

Bioprinting is one of the newest scientific developments in the NBICS convergence (convergence of nano-, bio-, information and cognitive technologies), which is a global phenomenon on a global scale. Research in the field of 3D tissue and organ printing is of a complex interdisciplinary nature, and is projected onto the biomedical landscape of organ transplantation issues. The paper deals with the legal issues of bioprinting as a technology in the field of biomedicine amid innovative activities in the healthcare system. The stages of bioprinting (preprocessing, processing, postprocessing) successively pass into each other, forming a trace complex of unresolved legal issues. There is a new phenomenon of objective reality, expressed in actions aimed at creating a new biogenetic product, while no norm of the current positive legislation can describe the process of creating and applying a reprint organ (biomaterial). The need to develop and systematize Russian legislation on the use of the results of innovative technologies in healthcare is justified taking into account the high criminal risk of harm to the human embryo. The paper identifies two groups of criminogenic threats depending on the use of biosafety and bioinsecure technologies in the field of bioprinting. The current criminal legislation makes it possible to classify criminal acts in the field of 3D technologies using the general bodies of crimes in the Special part of the Criminal Code of the Russian Federation. However, the mechanisms of criminal legal protection need to be improved by developing special norms that block harm to biogenetic human rights. Since the common element in all crimes related to bioprinting technologies is the object of the crime, it is necessary to determine that the moment when criminal legal protection of human life begins is from the moment of fertilization of an egg by artificial or natural means. It is important to use the general term «human embryo», which includes all stages of embryonic and fetal development.
Comparative characteristics of the chemical structure of ormokers and traditional composites
Authors: Bordina Galina E. , Lopina Nadezhda P. , Andreev Alexey A.
Published: January 2023

This article presents a review of the advantages of using ormokers rather than composite filling material from a chemical point of view. Ormokers are a modified type of hybrid organo-inorganic dental material. They were developed to reduce the shrinkage of filling material from polymerization, improve edge adaptation and abrasion resistance, and increase biocompatibility (compared to composites). The new matrix is based on inorganic polymers, which are polycondensed siloxanes (triblock copolymers). The formation of an inorganic chain of molecules occurs by hydrolysis and polycondensation of Si(OR) groups. Unstable organosilanols are formed from chlorine-containing silanes, as at least two hydroxyl groups are associated with one carbon atom. Such compounds do not exist, as they are rapidly isomerized to form carbonyl compounds (aldehydes and ketones). The resulting organosilanols are then oligomerized to form polysiloxanes with polymerized groups. The basis for the production of ormokers is the sol-gel process. The classical approach involves the formation of an inorganic grid by hydrolysis and condensation of a monomeric organic alkoxy compound followed by crosslinking of the introduced reactive groups (e.g., ultraviolet polymerization). The traditional synthesis of ormokers begins with the finding that alkoxysilanes are functionalized by metal alkoxides to form Si-O-Si nanostructures. One of the metals that functionalizes alkoxysilanes is titanium. In addition to titanium alkoxide, zirconium- or aluminum-alkoxides can be used. These oligomers replace traditional methacrylic monomers in composites. Composite filling materials available today based on the ormoker technology are not pure ormoker systems. Traditional methacrylate monomers-diluents are used to regulate the viscosity of the condensate, which does not improve biocompatibility. The presence of an amide group in the structure of the ormoker increases their biocompatibility with protein compounds in dental tissues.
Experimental and clinical study of the concentrations of chemical elements in oral fluid from prostheses and implants
Authors: Ragulin Arseniy V. , Olesov Egor E. , Zhukova Yulia S. , Olesova Valentina N.
Published: January 2023

BACKGROUND: Electrochemical reactions can occur in the mouth of patients with prostheses made of metal alloys. The phenomena of galvanism reflect the hidden process of corrosion of structural alloys in oral fluid, which makes it necessary to analyze the chemical contents of prostheses under clinical conditions in patients with implants and experimental conditions.
AIM: Comparative analysis of the trace element content in the oral fluid from prostheses in implants in the clinic and an experiment.
MATERIALS AND METHODS: National Research Technological University MISIS analyzed artificial saliva after prostheses were in contact with grade 4 and grade 5 implants for 3 months. Titanium, cobalt, chromium, aluminum, vanadium, molybdenum, tungsten, manganese, nickel, and iron were determined by spectrometry. The same chemical elements were analyzed using an identical spectrometric method in 32 patients with fixed dentures on implants.
RESULTS: Under the experimental conditions, nine trace elements were found in the container around one grade 4 implant with a crown, including titanium (0.4 g/l), cobalt (3.8 g/l), chromium (0.5 g/l), aluminum (2.6 g/l), vanadium (0.6 g/l), molybdenum (1.5 g/l), tungsten (3.0 g/l), manganese (0.9 g/l), nickel (0.5 g/l), and iron (0.6 g/l). The grade 5 implant was characterized by a greater degree of diffusion of aluminum, nickel, and manganese into artificial saliva. Mass spectrometry of the oral fluid in patients with dental implants revealed more trace elements than experimental data. The difference in the concentration of microelements from the prostheses under clinical conditions and in the experiment ranged from 0 to 128 times the minimum.
CONCLUSION: Fixing experimental prostheses on implants for 3 months in artificial saliva was accompanied by the diffusion of microelements from the prostheses and implants into the environment, particularly cobalt, aluminum, and vanadium. Prostheses on implants with a lower titanium content are characterized by a greater degree of diffusion of aluminum, cobalt, nickel, and manganese. More significant diffusion of microelements occurred from the prostheses into the saliva under clinical conditions, according to the spectrometric data.
Magical thinking in normal and pathological conditions: literature review
Authors: Chertischev Michail S.
Published: January 2023

The scientific literature analysis on a magical thinking problem was conducted. A review of studies in a historical perspective on this problem was given (English anthropological and French sociological schools, psychoanalysis views), various descriptions of magical thinking structure and possible causes of its development were discussed. A brief review of experimental studies of magical thinking of people without mental pathology is described as well as a specificity of magical thinking in childrens mind. The study of magical thinking in various mental pathologies is considered as one of the forms of psychosis-like experiences, as well as the phenomenon of thought action fusion.
Penyelesaian Sengketa Waris yang Berkeadilan pada Masyarakat Adat Suku Kajang Kabupaten Bulukumba
Authors: Akib Muhammad Kibar , Koeswahyono Imam , Sulistyarini Rachmi
Published: January 2023

This study aimed to analyze the obstacles to the settlement of inheritance disputes in the Kajang indigenous people and the efforts to settle inheritance disputes in a just manner in the Kajang indigenous peoples. The type of research used in this study was empirical juridical with an anthropological approach—sources of data obtained from primary and secondary legal materials. Data collection techniques were carried out through interviews. The data obtained were analyzed using descriptive methods. The results of this study indicated that the obstacles to the settlement of inheritance disputes in the Kajang indigenous people were the parties making false confessions, insisting on defending their rights and social status, tending to be emotional, and lacking firmness from the mediator. Efforts to settle inheritance disputes that were fair to the indigenous people of the Kajang tribe are carried out based on local wisdom based on pasang ri kajang through three stages, namely deliberation at the hamlet head level, mediation by the village head, and the customary justice institution.
Pendidikan Politik Sebagai Usaha Partai Politik Menyemai Nilai-Nilai Pancasila dalam Kehidupan Keorganisasiannya
Authors: Wibowo Arif Prasetyo , Yusuf Nurbani
Published: January 2023

This study aimed to describe the meaning of political education for political parties, the relationship between the party platform and Pancasila values, approaches, media, and methods used by political parties in political education, as well as obstacles and efforts of political parties in the implementation of political education. This study used a qualitative approach with a comparative study method. Data was collected using interviews, observation, and documentation studies. Political education carried out by political parties to their cadres was interpreted as an educational effort to improve the quality of human resources. The platform of political parties was a reflection of the values of Pancasila. The approaches, methods, and media parties used in political education were diverse. Obstacles and efforts of political parties in implementing political education, including funding and attendance of members, were resolved by making donations and completing the results of the minutes of each meeting.