bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Harga, Review Produk, Affiliate Marketing Terhadap Keputusan Pembelian pada Sosial Commerce
Authors: Fadila Maylia Elsa , Sihabudin Sihabudin , Fauji Robby
Published: June 2024

Tujuan penelitian ini untuk mencari tahu bagaimana harga, review produk, dan affliliate marketing mempengaruhi keputusan pembelian konsumen. Penelitian ini menggunakan teknik kuantitatif sebagai metodologi penelitiannya, dan sumber data primernya adalah kuesioner yang diberikan kepada responden. Populasi penelitian terdiri dari seluruh individu yang menggunakan platform social commerce. Temuan dari penelitian ini diharapkan dapat memberikan pemahaman mengenai dampak harga, review produk, dan affiliate marketing terhadap keputusan pembelian. Hasil penelitian ini diharapkan memiliki implikasi praktis yang akan membantu para praktisi pemasaran dalam mengembangkan strategi yang efektif untuk mengatasi tantangan dalam pemasaran digital, dengan tujuan akhir meningkatkan pembelian produk.
Deteksi Email Spam dengan Continuous Bag-Of-Words dan Random Forest
Authors: Rustam Michiavelly , Brotokuncoro Agung , Roestam Rusdianto
Published: June 2024

Spam email poses a significant cyber threat, as scammers employ various tactics to deceive individuals into divulging sensitive information or downloading harmful content. For instance, in June 2023, Indonesia encountered approximately 6.51 thousand spam attacks, underscoring the widespread nature of this issue. These attacks frequently involve deceptive strategies, such as impersonation or false promises of rewards, to ensnare unsuspecting victims. Succumbing to spam can result in financial losses and other grave repercussions. To address this concern, this research addresses this pressing problem by focusing on email content classification to detect phishing attempts. The proposed solution leverages runtime platforms such as Google Colab and uses Continuous Bag of Words (CBOW) analysis and Random Forest methods. CBOW is selected for its effectiveness in capturing semantic relationships between words, allowing the model to extract meaningful features from the email content. Random Forest, on the other hand, is chosen for its ability to handle imbalanced datasets commonly encountered in email classification tasks, ensuring fair representation of both spam and ham emails during model training. By combining these two techniques, we aim to develop a robust classification model capable of accurately distinguishing between phishing (spam) and legitimate (ham) emails, thus enhancing email security measures. Through our approach, we aim to classify the SpamAssassin dataset into ham or spam categories, with an anticipated precision rate of 0.98, demonstrating the model's effectiveness in accurately identifying phishing emails.
Manajemen Pengelolaan Kelas pada TK Az-Zahra Baru Ranji Merbau Mataram Lampung Selatan
Authors: Marsi Marsiyah , Sugiyanto Sugiyanto , Dewantari Tri
Published: June 2024

Pengelolaan kelas merupakan suatu usaha yang dilakukan oleh guru untuk menciptakan suasana kelas yang optimal dan mengembalikannya bila terjadi hal-hal yang dapat mengganggu kenyaman kelas. Manajemen kelas merupakan faktor yang sangat penting untuk mempertahankan kondisi kelas agar selalu efektif. Rumusan masalah penelitian yang penulis ajukan adalah “Bagaimana Manajemen Pengelolaan Kelas di TK Az-Zahra Baru Ranji Merbau Mataram Lampung Selatan”. Tujuan yang ingin dicapai pada penelitian ini adalah untuk menggambarkan serta mengetahui bagaimana manajemen pengelolaan kelas di TK Az-Zahra Baru Ranji Merbau Mataram Lampung Selatan. Adapun metode penelitian yang digunakan adalah kualitatif deskriptif yang melibatkan guru dan kepala sekolah. Teknik pengumpulan data meliputi observasi,wawancara,dan dokumentasi. Hasil penelitian menunjukkan bahwa Manajemen Pengelolaan Kelas di TK Az-Zahra Baru Ranji Merbau Mataram Lampung Selatan dimulai dari: 1) penataan sarana dan prasarana telah disesuaikan dengan kegiatan yang akan dilakukan, 2) pengelompokan meja dan kursi sudah disesuaikan dengan kegiatan anak sehingga anak leluasa dalam bergerak, 3) Peletakan alat bermain dan bermain sudah di atur sedemikian rupa sesuai dengan fungsinya, 4) alat kegiatan pengaman diatur dalam ruangan, 5) kelas dirancang dengan warna-warna yang disukai anak, 6) pengaturan ventilasi dan cahaya sudah diatur dengan baik.
Generalized Yang Poisson Models on Canonical Phase Space
Authors:   University of Split, Croatia, Martinić Bilać Tea , Meljanac Stjepan ,   Ruder Bošković Institute, Croatia, Mignemi Salvatore ,   Università di Cagliari, Italy
Published: June 2024

We discuss the generalized Yang Poisson models. We construct generalizations of the Yang Poisson algebra related to $\mathfrak{o}(1,5)$ algebra discussed by Meljanac and Mignemi (2023). The exact realizations of this generalized algebra on canonical phase space are presented and the corresponding differential equations are solved in simple cases. Furthermore, we discuss the Poisson algebras related to $\mathfrak{o}(3,3)$ and $\mathfrak{o}(2,4)$ algebras.
Good vision – good driver
Authors: Pitakova Ivelina J. , Kozhuharov Todor , Mitsova Dimana
Published: June 2024

Vision is a complex act that allows the visual analyzer to perceive and analyse objects in the environment. The teams of two eye clinics conducted a “good vision-good driver” awareness campaign in combination with a survey. In most countries in the world, drivers over the age of 65 are required to renew their licences every 2 or 3 years. The European Commission wants car drivers over 70 to prove their ability every 5 years. The aim was to analyze the relationship between patients’ visual performance concerning their self-reported driving and their subjective general health. The survey was conducted through a direct survey at St. Nikolay Chudotvorets Eye Clinic Eye Clinics from 1.06.2021 to 31.06.2022. For the period, 103 patients were surveyed, 84 male and 19 – female. The group of 50–70-year-olds was the most numerous. Uncorrected vision equal to or less than 0.3 was present in 45.6% of all 206 eyes. Almost all respondents drove a car, only 3 were not drivers, and most (50.9%) had no difficulty driving. More than 42% of the respondents found driving difficult only at night, and 6.8% had difficulty always. There is an overlap in the results of the questions of whether the patient had had a traffic accident – positive in 13.7% and whether they had ever had a stroke. The ability to drive is a multifactorial process in which vision plays an undeniable role. Visual acuity reflects the need for correction in the driving licence. The present research proves the need because it shows patients with poor vision driving and not at a young age who overestimate their general and visual objective condition.
Un deuil en présence ou représenter la mort à l’œuvre
Authors: Ambresin Gilles , Despland Jean-Nicolas
Published: June 2024

Crise et métamorphose institutionnelles ouvrent inévitablement la question du deuil d’un objet en cours d’être perdu. Cet article explore cette question du deuil « en présence » en s’appuyant sur le travail du peintre F. Hodler. Hodler suit minutieusement la piste de la transformation lente, progressive et profonde de l’agonie de son amante, Valentine Godé-Darel. Il propose par son geste pictural une véritable métamorphose de sa relation avec elle, mais aussi celle d’un changement de nature et de structure du lien qui les relie. Dans le processus de deuil en présence se conjuguent retrait par touches de la libido, métamorphose de la représentation du lien en incarnation picturale, conjointement à la métamorphose du lien à l’objet en « un lien plus intime du moi avec le monde environnant » (Freud).
La crise suicidaire à l’adolescence
Authors: Joubert Catherine
Published: June 2024

La crise suicidaire est une des pathologies emblématiques de l’adolescence. Sa fréquence, en constante augmentation, pose différentes questions : quel est le rôle des facteurs extérieurs comme la société, la famille, ou l’école ? Mais surtout quels sens donner à ce « scandale doublé d’une énigme », qui vise à rompre les liens de façon dramatique avec l’entourage, en miroir d’une difficulté à remodeler le lien avec les objets internes du sujet ? La réponse soignante se doit d’assumer l’urgence mais aussi d’être prudente et plurielle. La question de la séparation à l’adolescence croisera celle de l’attaque du corps propre et du meurtre en soi des objets intériorisés. Le soin se situe à l’endroit précis d’une tentative de métamorphose de soi et de son environnement au-delà du geste suicidaire.
Comment les institutions meurent-elles ?
Authors: Kapsambelis Vassilis
Published: June 2024

La génération des travailleurs en santé mentale actuellement en exercice travaille dans des institutions qui ont été créées par la génération précédente, celle de l’immédiat après-guerre, qui a porté la contestation et la réforme de l’asile psychiatrique, unique institution de soins dans cette discipline pendant un siècle et demi. Ces bouleversements ont abouti à la mort de l’asile, bien qu’à travers des chemins multiples et en partie contradictoires. L’effort de transformation de l’asile a toutefois légué aux institutions qui lui ont succédé un sens du travail en équipe et une vaste utilisation des médiations thérapeutiques. Les institutions issues de la réforme connaissent à leur tour différentes formes de mort. Nous en isolons trois : le meurtre, la momification et l’euthanasie, tout en rappelant que toute institution, en tant qu’organisme vivant, est appelée à mourir un jour.
Autour de l'œuvre de Jean-Paul Valabrega
Authors: Moreau Ricaud Michelle
Published: June 2024

Lors de cette journée d’hommage à Jean-Paul Valabrega, nous brossons rapidement son portrait en tant qu’homme et résistant. Sa trajectoire analytique, qui va de la SPP au Quatrième Groupe, en fait une figure importante de l’histoire mouvementée de la psychanalyse en France. Nous avons choisi de mettre l’accent sur sa critique de la formation analytique rigide, dogmatique, transmise par l’API, dans la première société analytique française, à l’origine de scissions et de fragmentation de la psychanalyse en France. Si l’exigence de l’analyse de l’analyste a été acceptée par tous, revisitant et réévaluant la notion de la « didactique », nécessairement bricolée au début du xx e siècle, nous comprenons mieux la contribution de J.-P. Valabrega à la formation analytique par sa théorie du contrôle analytique, l’« analyse quatrième », renouant avec l’esprit de libération à la source de l’invention freudienne.
Autour de l'œuvre de Jean-Paul Valabrega
Authors: Bazalgette Gérard
Published: June 2024

Théorie de la connaissance psychanalytique et théorie psychanalytique de la connaissance. C’est à cet entrecroisement que s’intéresse particulièrement Jean-Paul Valabrega en ouvrant dès lors un champ de recherche à la fois psychanalytique, épistémologique et anthropologique. Cet article se nourrit de cette recherche et tente de la prolonger. Comment le sujet, enfermé dans des significations et des discriminations aporiques, invente-t-il le sens qui l’en libère tant sur un plan individuel que collectif ? Et quel rôle tiennent le phantasme et le mythe dans cette création humaine qui est, de tout temps, celle du symbole ?
Autour de l'œuvre de Jean-Paul Valabrega
Authors: Lévy Ghyslain
Published: June 2024

Le savoir relève toujours d’un désir ombiliqué à de l’irréductible, ouvert sur de l’inconnu, le chercheur étant d’abord un rêveur, son désir de savoir étant toujours désir de se retourner sur cet ombilic. La question marrane relève d’une résistance de type cryptique visant à soutenir le sujet dans un désir de savoir qui ne soit pas détourné sous l’effet d’emprise de la volonté du maître. Interroger par ailleurs le concept d’interprétation latente en passe par la nécessité de s’arrêter sur la fonction mutative de l’interprétation comme procédure énonciative faisant œuvre de détachement des fixations moïques et de travail de deuil à partir desquels peut émerger la subjectivité. En ce qui concerne le mythe, celui-ci n’est-il pas à penser en écho à l’angoisse que portent les questions du sujet humain quant à son origine et son ultime ? Le mythe n’est-il pas la projection à l’extérieur d’une auto-perception interne de la psyché quant à son propre fonctionnement ? Et qu’en est-il de la fonction du rite comme le performatif énigmatique du mythe ?
Psychoalcoologie fondamentale et théorique
Authors: Menecier Pascal
Published: June 2024

La co-occurrence apparaît en médecine comme une association, au risque de passer sous silence les liens, fondements et origines de ce qui n’est que rarement le seul fruit du hasard. Même si le modèle addictif, globalisant, permet d’envisager des transferts de dépendance et des choix successifs de produits, la psychologie permet de penser ces associations que la coïncidence ne peut seulement expliquer. Autour de l’alcool, diverses autres consommations de psychotropes apparaissent, souvent avec troubles de l’usage, utiles à rechercher et à considérer au même titre que le mésusage d’alcool, dans l’intérêt des soignés.
Psychoalcoologie fondamentale et théorique
Authors: Menecier Pascal
Published: June 2024

Concept développé en fin du xx e siècle autour des toxicomanes à l’héroïne, la notion de réduction des risques et des dommages s’est répandue en addictologie comme une alternative humaniste à certaines approches morales centrées sur le seul sevrage. Autour des troubles de l’usage d’alcool, ce paradigme permet une approche graduée prenant d’abord en compte les préférences du patient, dans une apparente modernité humaniste, qui n’était pas forcément absente des stratégies antérieures.
Psychoalcoologie fondamentale et théorique
Authors: Menecier Pascal
Published: June 2024

Avec cinq millions de malades du boire et vingt-cinq millions du voir-boire 1 , un soignant sur deux peut être concerné en France par la question du mésusage d’alcool dans sa vie extraprofessionnelle. D’abord à titre personnel, quand le mésusage d’alcool a (au minimum) la même prévalence parmi les soignants qu’en population générale et peut interférer avec ses aptitudes dans les soins. Ensuite par ses entourages familiers, où l’expérience d’avoir côtoyé une proche mésusant d’alcool est associée à des attitudes soignantes plus favorables. Enfin en milieu professionnel, lorsque le mésusage d’alcool peut concerner des collègues, influer sur son propre travail et altérer le service rendu aux soignés.
From Digital Satire to Feminist Counterpublic Discourse: A Study of Participatory Mashups in China During the COVID-19 Pandemic
Authors: Xiao Fan , Huang Yue
Published: June 2024

The COVID-19 pandemic has challenged the effectiveness of China’s state apparatus and accumulated social discontent in the first half of 2020. Aided by a creative adaptation of a popular music video, a group of Chinese feminists initiated a short-term movement on the Chinese Internet in protest of the propaganda campaign of the Communist Youth League of China. The debut of two anime characters (Jiangshanjiao and Hongqiman) amid the pandemic stirred up strong grievances which led to an online feminist movement. Utilizing mashup videos, the movement, though ephemera, delivered a powerful counter-public discourse of women’s sufferings, which resonated widely in the digital sphere. Adopting a cultural perspective of Internet memes, this study closely examined the metamorphosis of a music video from an apolitical fanatic tool to sarcastic “guichu” mashups and eventually a powerful feminist counter-public discourse. Findings from this study suggest the strong potential of participatory mashups in the articulation of counter-public narratives from grassroots Internet users.
Approches sémiotiques et langagières en physique et en mathématiques
Authors: Bécu-Robinault Karine , Radford Luis
Published: June 2024

In physics and mathematics, there is a growing interest in studying the meanings that teachers and students construct through the mobilization of several semiotic systems, including embodied action, such as gestures, body postures, rhythm and speech. In this article, we propose a comparison of two approaches, developed in parallel in each of these disciplines. In physics, it is the function of models in the scientific community of physicists that guides the consideration of semiotic systems to account for the reciprocal meaning of material situations and taught concepts. In mathematics, it is the very nature of activity - considered at the same time as ideal, material and sensible - which leads to a consideration of the semiotic systems which underlie it, a consideration which allows us to shed new light on the processes of teaching and learning
Deux approches contrastées de l’évaluation internationale PISA
Authors: Job Pierre , Le Hebel Florence , Schneider Maggy
Published: June 2024

This article addresses the theme of assessment through the prism of two different approaches to the international PISA assessment. The first approach focuses on the understanding and solving of PISA science items by students of different academic performance and socio-economic and cultural levels in the context of France. In the second approach, PISA is used to expose how mathematics didactics, essentially equipped by the theory of didactic situations and the anthropological theory of didactics, allows to question the notion of evaluation considered as a process and is situated in the context of French-speaking Belgium. The discussion is structured around three points: the epistemological depth of the assessment process, assessment as a tool for analysis and understanding in order to better deal with the heterogeneity of learners, and the place of teachers within the assessment process.
Die Bedeutung der Sprache
Authors: Wanninger Thedor
Published: June 2024

Ausgehend vom Paradigmenwechsels des linguistic turns stellt der Aufsatz die methodischen Rahmenbedingungen der Begriffsgeschichte dar. Dabei wird aufgezeigt, dass das umstrittene Element des Begriffs entbehrlich ist. Die an der Begriffsgeschichte geäußerten Kritiken werden untersucht. Zuletzt wird argumentiert, dass an Stelle des limitierenden methodischen Rahmens der Begriffsgeschichte die Kenntnis über die verschiedenen Funktionen der Sprache in der Arbeit des Rechtshistorikers treten sollte.
Prémisses ordonnatrices (L’ordre juridique médiéval)
Authors: Grossi Paolo
Published: June 2024

Le chapitre 2 de L’ordine giuridico medievale, intitulé « Prémisses ordonnatrices », présente les questions méthodologiques fondamentales qui sont au cœur de l’ouvrage. Après avoir discuté l’historicité du droit, l’auteur introduit les notions d’« ordonnancement juridique » et d’« expérience juridique », qui sont à la base de sa compréhension du droit médiéval. Le Moyen Âge est décrit comme une expérience unitaire, caractérisée par la présence d’une multiplicité d’ordonnancements juridiques.
Modernité politique et ordre juridique
Authors: Grossi Paolo
Published: June 2024

Paolo Grossi entend apporter le regard de l’historien du droit à la définition de la modernité politique. Il décrypte le lent basculement qui s’opère dans la conception du droit du xive à l’aube du xixe siècle, en s’appuyant en particulier sur le cas du royaume de France. Il cherche à démontrer que la modernité politique se caractérise par un processus d’individualisation qui inverse les rapports entre droit et politique : alors qu’au Moyen Âge « d’abord il y a le droit ; le pouvoir politique ne vient qu’ensuite », désormais « la certitude élémentaire est qu’avant le droit, il y a l’État ».
Mercedes Cabello de Carbonera en la prensa de París y Nueva York: modernidad transatlántica y proyecto americanista
Authors: Moreno Mónica Cárdenas , Briggs Ronald
Published: June 2024

La escritora peruana Mercedes Cabello de Carbonera (1842- 1909) participó a lo largo de su carrera literaria, entre 1874 y 1896, en revistas y prensa extranjera. En este artículo se analizan dos etapas importantes de dicha participación: su colaboración en prensa parisina y su etapa neoyorquina. Estos dos centros ejemplares, de una cultura y modernidad hegemónicas occidentales, utilizan la prensa ilustrada en español como medio de difusión y conquista de un público latinoamericano. A través de esta prensa, Mercedes Cabello se convierte en una interlocutora válida que dialoga con autores, tanto de la tradición anglosajona como francesa, y por lo tanto capaz no solo de refutar el predominio español sobre los escritores hispanoamericanos, sino de defender un americanismo intelectual y, dentro de él, una participación femenina en los debates culturales y de política internacional de finales del siglo XIX. La presencia de Mercedes Cabello en el escenario internacional le permite también visibilizar la necesidad de nuevas alianzas político-económicas entre Perú y las principales economías de Occidente.
Bordando con tinta negra: prensa y autoría femenina en la revista La Mujer Mexicana (1904-1908)
Authors:  Chávez Ximena Yáñez ,  Díaz Ana Laura Zavala
Published: June 2024

En el presente artículo nos interesa estudiar algunas de las estrategias discursivas de construcción autorial de las escritoras que participaron en la revista La Mujer Mexicana (1904-1908), vocera de la Sociedad Protectora de la Mujer. Si al hablar de autoría se piensa en formatos que ponen en escena a sujetos individuales, las publicaciones en las que se reúnen las firmas de más de un nombre —periódicos, revistas o antologías— son, igualmente, fabricantes de capital simbólico autorial, colectivo y colaborativo. Compartimos con Beatriz Sarlo la idea de que los impresos de circulación periódica son un punto de partida para indagar sobre las transformaciones institucionales y sociales que afectan al discurso literario; por ello, consideramos que la revisión de esta revista permite aproximarse a las nociones de “escritora” y “escritura femenina” que circularon a contracorriente de la cultura dominante mexicana de principios del siglo xx.
Feministas por la paz. La prédica contra la guerra y militarismo en los albores del feminismo rioplatense
Authors: Manzoni Gisela
Published: June 2024

Este artículo se propone visibilizar las posiciones que la revista Nosotras difundió sobre la guerra, el militarismo y la paz durante su existencia (1902-1904). En efecto, aquellos tiempos fueron testigos de un contexto mundial que ya anunciaba las grandes guerras del siglo XX. Para ello seleccionamos diferentes intervenciones referidas a estos temas, prestando especial atención a las de su directora, María Abella. Ella se ocupó especialmente de la guerra civil en Uruguay. Al mismo tiempo, el artículo aspira a contribuir a la caracterización de esta publicación que, a pesar de su importancia, ha sido poco estudiada de forma sistemática o como objeto cultural.
La Asociación Sud-Americana de Paz Universal y Ángela Oliveira Cézar: pacifismo, activismo trasnacional y «diplomacia femenina»
Authors: Bruno Paula
Published: June 2024

El artículo analiza la Asociación Sud-Americana de Paz Universal (Buenos Aires, 1907) como espacio de acción femenina que abrazó los ideales del pacifismo internacionalista. La asociación fue proyectada y creada por la argentina Ángela Oliveira Cézar (1860-1940), quien devino una figura de referencia del pacifismo internacional del pasaje del siglo XIX al XX. A partir del itinerario de su fundadora y de las dinámicas de la asociación y recurriendo a fuentes de distinto tipo –documentación de la agrupación (estatutos, correspondencia, libros editados para determinadas coyunturas), prensa periódica nacional e internacional, documentación oficial, correspondencia personal–, se estudian las posibilidades y los límites de mujeres latinoamericanas en el emprendimiento de acciones motivadas por la confraternidad americana y el pacifismo internacional y se muestra la articulación entre las repercusiones locales, regionales y transnacionales de sus iniciativas. Asimismo, se hace foco en las acciones que promovió la asociación en contextos de conflictividad y confraternidad entre países del continente americano –como el emplazamiento del Cristo de los Andes en el límite entre Chile y Argentina, corolario simbólico de la firma de los Pactos de Mayo de 1902–. El ensayo se inscribe en la «nueva historia diplomática», un área en desarrollo que ha dado lugar al estudio de las mujeres en escenarios transnacionales.
Tuberculous pericardial effusion causing tamponade in a healthy young male:  A diagnostic and therapeutic challenge of a rare manifestation of a fairly frequent disease in Sri Lanka: A Case Report  
Authors: Nasim Fathima Nujha , Herath Lasitha , Bowattage Sunil Bandara , Kularatne Wickramasooriyage Kiertie
Published: June 2024

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Efficacy of Pazopanib on Primary Patient-derived Undifferentiated Malignant Round Cell Sarcoma Line
Authors: Vasudevan Smreti , Mehta Anurag , Rohela Himanshu
Published: June 2024

Introduction:

Undifferentiated round cell tumours (URCTs) are rare and less researched Ewing-like mesenchymal tumours that primarily affect bones and soft tissues. Therapeutic options for advanced URCT are limited. Pazopanib, a multi-tyrosine kinase and angiogenesis inhibitor, is currently used for managing advanced soft-tissue sarcoma. However, its efficacy in the treatment of URCT remains uncertain and has not been established. In this study, we have cultured and characterised a patient-derived URCT cell line to understand the in vitro growth properties and anti-cancer agent sensitivity.

Materials and Methods:

Primary cell culture was performed by mechanical and enzymatic dissociation of URCT tissue specimens to derive a cell line. Morphology, growth properties and immunological features characterised the cells. Further, the in vitro sensitivity for clinically used anti-cancer drugs was evaluated.

Results:

The URCT cell line was established from a high-grade round-cell tumour patient. The cells had mesenchymal morphology and showed cyclin B3 (CCNB3) positivity, which was confirmed in the tissue from the patient. The cells exhibited an anchorage-independent growth property and aggregated to form spheroids in a non-adherent in vitro system. Anti-cancer agents vincristine, doxorubicin, etoposide and pazopanib inhibited URCT cell proliferation. Pazopanib exhibited cytotoxic action in URCT cells, leading to cell death.

Conclusions:

This is an early report of cultured URCT cells expressing CCNB3, studied in
vitro. The patient-derived model suggests the efficacy of pazopanib in URCT cells. The characterised line will be helpful to advance sarcoma studies.
Fibrin Network Pattern Changes of Platelet-rich Fibrin in Chronic Periodontitis Patients with and without Diabetes Mellitus
Authors: Priya Swathi , Elangovan Gayathri Priyadharshini , Vivekanandan Gopinath , Saranya Settu , Surya Duraisamy , Elumalai Ahila
Published: June 2024

Introduction:

Platelet-rich fibrin (PRF) has been widely applied for periodontal regeneration due to its simplicity, autologous nature and economics. This study aims to evaluate the variations in the fibrin network patterns of the PRF clot, which was isolated from chronic periodontitis patients with and without diabetes mellitus (DM).

Materials and Methods:

This study included 90 participants undergoing periodontal treatment therapy. The patients were divided into three groups: Group A (n = 30), chronic periodontitis patients without Type 2 DM; Group B (n = 30), chronic periodontitis patients with Type 2 DM (haemoglobin A1c [HbA1c], 6.5%–6.9%) and Group C (n = 30), chronic periodontitis patients with Type 2 DM (HbA1c ≥ 7%). The clinical parameters and blood samples were collected, and PRF preparation was done. Histological slide analysis was done in the stained section of the PRF clot and examined for the presence of dense and loose fibrin network patterns with the entrapments of platelets.

Results:

There was a significant difference in the dense and loose fibrin framework between chronic periodontitis patients without type 2 DM, chronic periodontitis patients with type 2 DM of 6.5–6.9 HbA1c and chronic periodontitis patients with type 2 DM of >7 HbA1c.

Conclusion:

Within the limitations of this study, future studies are needed to find the clinical outcomes of various PRF preparations in diabetic patients and other systemic factors that influence the fibrin network pattern, so that better regenerative outcomes can be achieved in patients with systemic diseases.
Comparison of Practice and Knowledge on Endodontic Retreatment amongst the General Practitioners and Endodontists: A Survey
Authors: Prabha Chandra , Shetty Chitharanjan , Kaur Gurmeen , Saji Shalin Ann , Bajpe Sunheri , Shroff Rashi
Published: June 2024

Introduction:

Endodontic retreatment differs from initial root canal treatment. Various factors govern the success of root canal treatment, and failure to achieve any of these may lead to the failure of the therapy. Retreatment decisions differ amongst general practitioners and specialists and are dependent on several factors including educational background, work experience, knowledge and economic resources. A survey was conducted to compare the practice and knowledge regarding endodontic retreatment cases amongst general practitioners and endodontists.

Materials and Methods:

A questionnaire was constructed with questions based on common practice and knowledge of endodontic retreatment and was distributed to general practitioners and endodontists through electronic means and personal mail. Data were analysed using the Chi-square test. P < 0.05 was considered statistically significant.

Results:

The results showed that there was no statistical difference in the responses by general dentists and specialists (endodontists).

Conclusions:

Within the limitations of this survey, it can be concluded that both the general practitioners and specialists (endodontists) have adequate knowledge and follow similar protocols when treating retreatment cases with minor differences in their approach.
Scriptaid is a prospective agent for improving human asthenozoospermic sample quality and fertilization rate in vitro
Authors: Yang Yi-Ting , Yan Bin , Guo Li-Na , Liu Miao , Li Yu-Hua , Shao Zhi-Yu , Diao Hua , Liu Su-Ying , Yu He-Guo
Published: June 2024

Male infertility is a global issue caused by poor sperm quality, particularly motility. Enhancement of the sperm quality may improve the fertilization rate in assisted reproductive technology (ART) treatment. Scriptaid, with a novel human sperm motility-stimulating activity, has been investigated as a prospective agent for improving sperm quality and fertilization rate in ART. We evaluated the effects of Scriptaid on asthenozoospermic (AZS) semen, including its impact on motility stimulation and protective effects on cryopreservation and duration of motility, by computer-aided sperm analysis (CASA). Sperm quality improvement by Scriptaid was characterized by increased hyaluronan-binding activity, tyrosine phosphorylation, adenosine triphosphate (ATP) concentration, mitochondrial membrane potential, and an ameliorated AZS fertilization rate in clinical intracytoplasmic sperm injection (ICSI) experiments. Furthermore, our identification of active Scriptaid analogs and different metabolites induced by Scriptaid in spermatozoa lays a solid foundation for the future biomechanical exploration of sperm function. In summary, Scriptaid is a potential candidate for the treatment of male infertility in vitro as it improves sperm quality, prolongs sperm viability, and increases the fertilization rate.
A novel missense mutation of CCDC34 causes male infertility with oligoasthenoteratozoospermia in a consanguineous Pakistani family
Authors: Ahmad Nisar , Yang Meng-Lei , Zeb Aurang , Zhou Jian-Teng , Zubair Muhammad , Abbas Tanveer , Jiang Xiao-Hua , Zhang Yuan-Wei , Zhang Huan , Shah Wasim , Shi Qing-Hua
Published: June 2024

Male infertility is a worldwide health issue, affecting 8%–12% of the global population. Oligoasthenoteratozoospermia (OAT) represents a severe type of male infertility, characterized by reduced sperm count and motility and an increased frequency of sperm with aberrant morphology. Using whole-exome sequencing, this study identified a novel missense mutation (c.848C>A, p.A283E) in the coiled-coil domain-containing 34 gene (CCDC34) in a consanguineous Pakistani family. This rare mutation was predicted to be deleterious and to affect the protein stability. Hematoxylin and eosin staining of spermatozoa from the patient with OAT revealed multiple morphological abnormalities of the flagella and transmission electron microscopy indicated axonemal ultrastructural defects with a lack of outer dynein arms. These findings indicated that CCDC34 plays a role in maintaining the axonemal ultrastructure and the assembly or stability of the outer dynein arms, thus expanding the phenotypic spectrum of CCDC34 missense mutations.
Nitrate-Induced Headache Response in Patients with Coronary Artery Disease and Coronary Artery Ectasia: A Retrospective Case-Control Study
Authors: Aksu Ekrem , Cuglan Bilal , Ozturk Selcuk , Eren Ali , Yalta Kenan , Turhan Hasan , Atmaca Hasan , Yetkin Ertan
Published: June 2024

Background:

Coronary artery ectasia (CAE), while being considered a variant of atherosclerosis, harbors distinct features that significantly differ from atherosclerosis in terms of pathophysiological mechanisms. On the other hand, headache appears to be the most common side effect of nitrates that have been used traditionally for decades. In this context, we aimed to compare the frequency and temporal characteristics of nitrate-induced headache (NIH) between subjects with sole coronary artery disease (CAD) and subjects with CAD and coexisting CAE.

Materials and Methods:

Two hundred and forty-four patients who had undergone coronary angiogram (CAG) and received a single dose of sublingual isosorbide dinitrate during the procedure comprised in this retrospective study population. CAG is performed in the indications due to guidelines. All patients who had undergone CAG were held under close supervision, at least, for 6 h following CAG (and administration of sublingual nitrate); duration and emergence time of NIH were recorded for all patients. Of these 244 patients, 225 patients having sole CAD were assigned to Group I, whereas 19 patients having both CAD and CAE were assigned to Group II.

Results:

NIH was observed in 19 out of 225 patients (8%) with sole CAD and in 9 out of 19 patients (56%) with CAD and CAE (P = 0.003). The mean interval between the administration of sublingual isosorbide dinitrate and NIH onset was significantly lower in Group II in comparison to Group I (44 ± 14 min vs. 87 ± 63 min, respectively, P = 0.018). However, the duration of NIH was comparable between the two groups (Group I: 203 ± 53 min vs. Group II: 173 ± 61 min, P = 0.24); logistic regression analysis revealed an independent association between NIH and CAE (odds ratio: 11.5, 95% confidential interval: 3.9–33.8, P < 0.001).

Conclusion:

We have demonstrated that sublingual nitrates might induce NIH more frequently in subjects with CAE and CAD in comparison to those with sole CAD. Furthermore, NIH has been demonstrated to be independently associated with CAE.
Prevalence of Metabolic Syndrome in Vitiligo Patients and its Relation to Vitiligo Severity – A Cross-Sectional Study
Authors: Bathina Navya , Ganni Sadhika , Kolalapudi Seetharam A. , Konala Subhashini , Dharavath Kalyan , Reddy Mandem T. K.
Published: June 2024

Background:

In vitiligo, there is a significant decrease in melanocytes and melanin. The decrease in melanin causes oxidative stress, with a chance of causing metabolic syndrome. Hence, there is a need to look for metabolic syndrome in vitiligo.

Aim and Objectives:

To estimate the prevalence of metabolic syndrome in vitiligo patients and to evaluate the relationship between the severity and progression of vitiligo and metabolic syndrome.

Materials and Methods:

A hospital-based cross-sectional study was conducted on 178 vitiligo cases and 178 controls who were age- and sex-matched. The type of vitiligo, stability by vitiligo disease activity score (VIDA), and severity by vitiligo area severity index (VASI) were noted. The waist circumference, blood pressure, fasting lipid profile, and fasting blood sugar were measured for cases and controls. Metabolic syndrome was diagnosed based on Harmonization Asian criteria.

Results:

The mean age in cases was 34.38 years, and in controls, it was 35.67 years. The majority were females in both cases (52.2%) and controls (55.6%). Most have a VIDA score of 2+ (41.6%). The mean VASI score was 2.54. The percentage of metabolic syndrome was higher in cases (36%) compared to controls (24.2%) (P = 0.015). The mean age was lower in vitiligo cases with metabolic syndrome (38.83 years) compared to controls with metabolic syndrome (43.14 years). Metabolic syndrome was more frequent in the vitiligo vulgaris type (48.9%) than in acral and segmental vitiligo. Metabolic syndrome was more common in patients with high VIDA (45%) and VASI (52.3%) scores compared to patients with low VIDA (25%) and VASI (27.3%) scores.

Limitation:

It is a hospital-based study, so controls were not from the general population.

Conclusion:

The prevalence of metabolic syndrome was higher in vitiligo patients compared to controls, and it was higher in patients with active and severe disease. Screening and close monitoring of vitiligo patients help in the early diagnosis of metabolic syndrome and reduce the risk of cardiovascular disease.
Phenotypes and endotypes in asthma-practical approach
Authors: Kathuria P.C. , Rai Manisha
Published: June 2024

Asthma is a complex heterogeneous inflammatory airway disorder. Inflammation is usually accompanied by an increase in airway smooth muscle mass, thickening of subepithelial lamina reticularis, matrix deposition in the airway walls, an increase in microvessels and neural networks, and mucus metaplasia. Clinical trials are going-on to evaluate the efficacy of biologicals or as an adjunct to allergen immunotherapy in high-T2 inflammation of allergic asthma. Management involves the titration of inhaled triple-drug therapy in a stepwise approach and to address the comorbidities. The targeted use of biological agents in severe diseases needs risk stratification of patients. We need further research on biomarkers and drivers of immune pathways in this era of changing global environment. This review will delve into personalized medicine strategies to treat asthma after phenotypic and endotypic characteristics.
Hypertension in Patients on Hemodialysis: Looking Beyond Stable Sessions
Authors: Jamboti Jagadish , Anupama Y J
Published: June 2024

ABSTRACT

Control of hypertension in patients on chronic haemodialysis is a clinical challenge and poses an important risk factor for adverse cardiovascular outcomes. The unique challenges faced by the clinician are highlighed by the given clinical case scenario. The multiple causes and the approach to its management are discussed in this article.
Utility of Fine-Needle Aspiration Cytology in Diagnosis of Lymphadenopathy
Authors: Chikkannaiah Panduranga , Guruprasad Channaigaramaiah , Venkataramanappa Srinivasamurthy
Published: June 2024

Introduction:

Abnormal shape, size, and consistency of the lymph node constitute lymphadenopathy. The etiology of lymphadenopathy varies from reactive to malignancy. It is the significant manifestation of local and systemic ailments specially an occult malignancy. Fine-needle aspiration cytology (FNAC) is a simple, reliable initial diagnostic modality.

Materials and Methods:

This is a retrospective study from January 2005 to December 2017. The lesions were classified into reactive lymphadenopathy, granulomatous lymphadenitis, necrotizing lymphadenitis, suppurative lymphadenitis, lymphoma, and metastatic lesions. Primary organ was identified in available cases of metastatic lesions. Cytological and histopathological correlation was done in available cases.

Results:

A total of 3676 cases were retrieved constituting 16% of total FNAC performed during the study, females outnumbered the male. Most of the cases were observed in the age of 21–30 years. Cervical lymph nodes were the common site of involvement (88.8%). Among the benign lesions, granulomatous (40%) was most common followed by reactive (39%). Metastatic lymphadenopathy (13%) was the most common malignant lesion. Squamous cell carcinoma was the most common metastatic tumor followed by adenocarcinoma. The lung was the most common primary organ. FNAC is having high sensitivity and specificity for malignant lesions than the benign.

Conclusion:

FNAC is a rapid, initial diagnostic tool for lymphadenopathy. It is an effective tool to differentiate inflammatory, benign, and malignant lesions.
The Screening and Identification of Atypical Red Cell Antibodies by Simultaneous LISS/Coombs and NaCl/Enzyme Gel Methods Prior to Blood Transfusion
Authors: Agrawal Purvee , Bhake Arvind
Published: June 2024

Background:

In this retrospective study, we measured the frequency of unexpected antibodies in the blood by Nacl/enzyme gel method or LISS/Coombs method and compared the result and frequency of identification in patients with a history of gestation or blood transfusion.

Aims and Objectives:

To detect unexpected/atypical red cell antibodies by simultaneous LISS/Coombs and NacL/enzyme gel methods prior to blood transfusion.

Materials and Methods:

Atypical antibody screening has done in all patients with the history of recurrent blood transfusion or history of gestation by commercially available red cell panel (ID–Dia panel, Diamed–ID Micro Typing System).

Results:

A total of 30 patients were screened for the presence of atypical antibody. Out of 30 patients, 1 (3.33%) patient showed the presence of alloantibody in the serum. The alloantibody identified was of anti-Lewis system.

Conclusion:

Screening for the presence of alloantibodies in patients is important to provide compatible blood and avoid adverse transfusion reactions.
A Study of Neurocognitive Dysfunction in HIV-Positive Patients in a Tertiary Care Center in South India
Authors: Shivaswamy Rajendra Prasad , Ashok Aparajitha , Jayaram Subhash Chandra Ballekere , Thandure Varsha , Dowerah Jenee
Published: June 2024

Context:

HIV-associated neurocognitive disorder (HAND) is an ongoing problem among HIV-positive patients, irrespective of whether the patients are on antiretroviral treatment (ART) or not. ART has helped in halting the progression of the disease, but still, research needs to be done in reversing the disorder. Patients on ART are still known to have a mild neurocognitive disorder. The prevalence of HAND is estimated in approximately 40%–50% of all cases.

Aims:

(1) To determine the presence of neurocognitive dysfunction in HIV-positive patients. (2) To determine sociodemographic factors that influence this condition. (3) To determine the relationship between CD4 count and neurocognitive dysfunction.

Settings and Design:

The sampling technique was purposive sampling. A cross-sectional study was undertaken in a sample size of 162 among patients attending the outpatient department of medicine department using the International HIV Dementia Scale (IHDS).

Subjects and Methods:

IHDS has the maximum possible score of 12 points. A patient with a score of ≤10 should be evaluated further for possible dementia.

Statistical Analysis:

Data entry was done in an Excel sheet. Data analysis was done using SPSS.

Results:

It was found that of the 162 patients who participated in the study, 71% were found to be at risk for the neurocognitive disorder. The factors which had a significant association were age, education, spouse alive or not, and HIV status of the spouse.

Conclusion:

It was found that out that neurocognitive disorder is common in the ART era and also it can be detected by simple bedside tests.
Treatment-Seeking Behaviors of Families for under Five Children in Field Practice Area of Jawaharlal Nehru Medical College, Wardha
Authors: Ingole Abhishek , Yadav Sheela , Gotarkar Shashank , Choudhari Sonali
Published: June 2024

Context:

Globally, India had the largest population of under-five (127 million), and the greatest number of under five deaths (2.1 million) in 2006. Nearly about 2 million of cases of diarrhea occur annually in India. An average Indian child below 5 years of age can have 2–3 episodes of diarrhea. It contributes to nearly 2.1 million of the global burden of 9.7 million under five deaths, which is the highest for any nation in the world. The Millennium Development Goal 4 aimed at reducing under-five mortality by two-third till year 2015 which remained unachieved and sustainable development goal 3 aims to ensure healthy lives and promote well-being for all at all ages including under-five children by the year 2030. The health and treatment-seeking behavior of parents and caregivers has direct reflection over child survival statistics of India. The present study has been conducted to study the determinants of treatment-seeking behavior of families for illness of under-five children in the field practice area of Jawaharlal Nehru Medical College (JNMC), Sawangi, Wardha, Maharashtra, India.

Aims:

A study on the treatment-seeking behaviors of families for illnesses of under-five children in field practice area of JNMC, Wardha, Maharashtra, India.

Objectives:

The objective of this study is to know the treatment-seeking behaviors of families for under-five children in rural areas.

Materials and Methods:

This study was carried out in the field practice area of community medicine JNMC, Sawangi Wardha, Maharashtra, India. The present study was carried out in the adopted villages from the field practice area of Wardha district by the JNMC. The present study was a community-based, cross-sectional study, and the study period was 6 months (i.e., from July 2019 to December 2019). The study participants comprised of the caregivers of children under-5 years of age and including mothers and other family members who were primarily responsible for attending the child's health. All children in the age group of 0 to 5 years from the study area were identified for the same (from Anganwadi's in the villages). The study participants, i.e., parents who were ready to participate in the study by signing the written consent were included in the study.

Statistical Analysis Used:

A predesigned and prestructured questionnaire was prepared and implemented for data collection.

Results:

The results showed that most of the under-five children were in the age group of 2–3 years. Most of the under-five children were having itching on skin followed by fever and diarrhea. Most of the parents took their under-five children to ANM's or the government hospital situated at their place.

Conclusions:

The present study concludes that treatment-seeking practices among parents for under-five children in the adopted villages of medical college are satisfactory in terms of qualified treatment provider and compliance to the treatment.
Study of Intrauterine Insemination with Hydrotubation in Women with Infertility
Authors: Srivastava Deepti , Shekhawat Harsha , Shelke Uttara
Published: June 2024

Background:

Hydrotubation is the instillation of a solution of medicine through the cervix into the uterus and fallopian tubes under pressure into the peritoneal cavity. It has little value to test whether or not the tubes are blocked in the investigation of infertility and therapeutically to flush or clean the fallopian tubes.

Materials and Methods:

Sixty women with unexplained infertility were scheduled randomly for hydrotubation either with saline or low-dose lidocaine in saline. Hydrotubation was carried out 1 day before intrauterine insemination (IUI) in clomiphene citrate stimulated cycle. Outcome measures were rates of pregnancy, first trimester abortion, ectopic pregnancy, multiple pregnancy, and procedure-related pain.

Results:

There were higher clinical pregnancy rates in lidocaine group which had when compared with saline group but statistically no significant difference found.

Conclusion:

Hydrotubation with low-dose lidocaine in saline 1 day before IUI allowed a significant higher pregnancy rate when compared to saline alone in couples with unexplained infertility.