bluuebunny/crossref_metadata_2025 huggingface dataset:
Carbapenem resistance determinants in Klebsiella pneumoniae strains isolated from blood cultures-comparative analysis of molecular and phenotypic methods
Authors: Tompa Manuela , Iancu Mihaela , Pandrea Stanca L. , Grigorescu Mircea D. , Ciontea Monica I. , Tompa Ronald , Pandrea Stanca M. , Junie Lia M.
Published: July 2022

Introduction: This study provides data on carbapenemases identified in carbapenem-resistant Klebsiella pneumoniae (CR-KP) isolated from blood-cultures by the multiplex molecular method.

Material and method: Between October 2016 and September 2017, 47 non-duplicate Klebsiella pneumoniae (KP) were isolated from blood cultures, from hospitalized patients in the Regional Institute of Gastroenterology and Hepathology, Cluj-Napoca, Romania. Identification and antimicrobial susceptibility tests (AST) were performed by Vitek 2 Compact. The combination disks test (CDT) was used for phenotypic analysis and the LightCycler® Multiplex DNA assay was used to detect and identify the carbapenemases by the LightCycler®z 480 Instrument. The following targets were chosen: blaKPC, blaNDM, blaGES, blaIMP and blaOXA-48 genes and the Cobas® 4800 software variant 2.2.0 was used for the results interpretation.

Results: Taking into consideration the meropenem minimum inhibitory concentration (MIC), 29 KP were susceptible and 18 were not-susceptible (MIC≥0.5 µg ml-1). In the CR-KP group, the CDT identified OXA-48 (10/18) and KPC (7/18) producers. One isolate showed a noninterpretable profile. The multiplex molecular analyses confirmed the carbapenemases production as: 9 CR-KP were KPC and OXA-48 co-producers, 8 were OXA-48 and one was KPC producing strains. In CR-KP group, we found a significant correlation between the CDT and RT-PCR tests results, concerning KPC (p = 0.671). Eight phenotypic results were confirmed by molecular Light-Cycler® Multiplex DNA assay. For CR-KP co-producers (KPC and OXA-48), the CDT could indicate only one carbapenem-hydrolyzing enzyme.

Conclusion: This study highlights the CR-KP co-producers (OXA-48 and KPC). OXA-48-like is more frequently encountered in our area than other carbapenemases.
SPP1 is a biomarker of cervical cancer prognosis and involved in immune infiltration
Authors: Guo Qian , He Wei , Nie Dan , Li Wuzhi , Zhan Ping
Published: July 2022

Background: Cervical cancer is the fourth commonly occurred cancer in women around the world. However, it still lacks effective approaches to improve current prognosis of cervical cancer and prevent metastasis.

Objective: We aim to discover a promising biomarker for cervical cancer prognosis by utilizing bioinformatics analysis.

Methods: Gene expression was analyzed by the datasets from The Cancer Genome Atlas Program-Cervical squamous cell carcinoma and endocervical adenocarcinoma (TCGA-CESC) dataset and three independent patient cohort datasets. Biological process and pathway enrichment were performed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis. Immune infiltration was analyzed through TISIDB tool.

Results: SPP1 gene was highly expressed in cervical cancer tissues. In addition, SPP1 was positively correlated to advanced CESC stages and nodal metastasis status. SPP1 co-expressed genes are mainly enriched in immunological processes. Furthermore, SPP1 expression is involved in immune infiltration level, in which several tumour infiltrating lymphocytes are correlated with SPP1. SPP1 overexpression promotes a wide spectrum of chemokines and immunoinhibiors which contribute to CESC progression.

Conclusions: SPP1 is a promising biomarker and a prognostic factor of CESC. Tumour infiltrating lymphocytes are also possibly regulated by SPP1. Our study suggests that investigation on SPP1 is a new direction for CESC therapy.
The Effects of Meteorological and Hydrological Conditions on Nutrient Losses from Agricultural Areas in Latvia
Authors: Siksnane Ieva , Lagzdins Ainis
Published: July 2022

Water quality in any stream is affected by complex interactions between natural and anthropogenic factors in a given catchment area. Agriculture has been identified as a major contributor of nitrogen and phosphorus inputs to surface waters in the Baltic Sea region. Although decisions regarding agricultural management practices, e.g. crop rotation, tillage, fertilization, have a direct impact on likelihood and magnitude of nitrogen and phosphorus losses from agricultural areas to surface waters, natural factors such as meteorological and hydrological conditions have a triggering role in processes determining transformations, storage, uptake and losses of nutrients. In order to investigate the effects of meteorological (precipitation and air temperature) and hydrological (runoff) conditions on water quality (losses of total nitrogen (TN) and total phosphorus (TP)) the results of the Agricultural Runoff Monitoring Programme collected at three monitoring sites (Berze, Mellupite, and Vienziemite) during the time period of 1995–2020 were summarized and analysed. The pronounced differences in mean annual air temperature and annual precipitation were observed when the meteorological information representing the periods of twenty years was compared indicating for evidences of climate change. In addition, the relationships between seasonal precipitation and runoff was detected. As affected by the hydrological behaviour the losses of TN and TP in agricultural catchments had large variations depending on the intensity of agricultural production and site location. The changes in seasonal and annual patterns of precipitation, air temperature and runoff may increase the risks of nutrient losses from agricultural catchments in the future.
Integrated Analysis of Municipal Master Plans and Multi-Year Plans in Light of Solid Waste Management: A Study Applied to the Southwestern Paraná State
Authors: Da Silva Christian Luiz , Ludwig Caroline
Published: July 2022

Purpose: The objective was to evaluate public policies related to municipal solid waste management in the southwest region of Paraná from an integrated analysis of municipal master plans and multi-annual plans.
Method/design/approach: The research is methodologically supported by the bibliographic and documentary analysis of secondary data, mainly from the Master Plans and Municipal Pluriannual Plans of the analysed municipalities and was developed in three phases: the first exploratory phase; the second descriptive, and finally, the third analytical phase.
Results and conclusion: The results showed that references were found in the master plans that can contribute to the implementation of integrated solid waste management together with urban planning, mainly from an environmental perspective. In all PPAs there were budget programs aimed at solid waste management, which is within the environmental dimension.
Research implications: The research demonstrate the need to align budget and planning instruments to ensure that public policies are effective and are in line with the assumptions of national policies.
Originality/value: A method of integrated analysis of budgetary instruments and municipal planning applied to waste management is presented, but which can be replicated in other areas. In addition, it contributes to the discussion of socio-environmental management practices in the municipalities and their alignment with the dimensions of sustainable development.
Reduced expression of neurogenesis genes as biomarkers of Parkinson's disease associated with mutations in the GBA gene: validation of the data analysis of transcriptome study
Authors: Bezrukova A. I. , Basharova K. S. , Miliukhina I. V. , Timofeeva A. A. , Senkevich K. A. , Pchelina S. N. , Usenko T. S.
Published: July 2022

The objective of the study was to validate our previous results obtained during the transcriptome analysis of the primary culture of peripheral blood macrophages in patients with Parkinson's disease associated with mutations in the GBA gene (GBA-PD) in that reduced expression of the neurogenesis genes EGR1 (early growth response protein 1), NR4A2 (nuclear receptor 4A2), JUNB (transcription factor jun-B) in patients with GBA-PD.

Methods and materials. The study included 14 patients with GBA-PD, 15 GBA-carriers, 30 patients with Parkinson's disease (PD) and 44 persons of the control group. The assessment of relative mRNA level of neurogenesis genes EGR1, NR4A2, JUNB in peripheral blood mononuclear cells were carried out by real-time quantitative polymerase chain reaction (PCR) using TaqMan fluorescent probes or EvaGreen fluorescent DNA dye.

Results. Relative mRNA level of the JUNB gene in peripheral blood mononuclears was decreased in the group of patients with GBA-PD compared to controls (p=0.034). We found out that the relative mRNA level of the NR4A2 gene in peripheral blood mononuclears was increased in the group of patients with GBA-carriers compared to GBA-PD, patients with PD and controls (p=0.0029, p=0.00045, p=0.0024 respectively). There were no statistically significant differences in the mRNA level of the EGR1 gene between all the study groups (p>0.05).

Conclusion. GBA-PD is characterized by reduced expression of the JUNB gene compared to control and of the NR4A2 gene compared to GBA-carriers.
FABP4 gene expression in subcutaneous and visceral adipose tissue in patients with obesity and type 2 diabetes mellitus
Authors: Dracheva K. V. , Pobozheva I. A. , Anisimova K. A. , Hamid Z. M. , Sapojnikova A. P. , Balandov S. G. , Vasilevsky D. I. , Pchelina S. N. , Miroshnikova V. V.
Published: July 2022

Introduction. Obesity is associated with a high risk of developing concomitant diseases such as: metabolic syndrome, type 2 diabetes mellitus (DM2), cardiovascular pathology. FABP4 (fatty acid binding protein) is the specific lipid chaperone and an important protein for the function of adipose tissue and is one of the adipocytokines secreted by adipose tissue.

The objective of the study was to investigate the FABP4 gene expression in subcutaneous and visceral adipose tissue (SAT and VAT) in patients with obesity and DM2.

Methods and materials. SAT and VAT samples were obtained during bariatric surgery (N=43, BMI>35): obese with DM2 (N=21), obese without DM2 (N=22). Samples for the control group without obesity (N=15, BMI<30) were obtained during planned operations on the abdominal cavity. FABP4 mRNA level was estimated by real-time PCR.

Results. It has been demonstrated that the mRNA level of the FABP4 gene in SAT and VAT is reduced in obesity, regardless of the manifestation of DM2 (p<0.01). A negative correlation was observed between the mRNA level of the FABP4 gene in adipose tissue and the BMI index (for SAT: r=—0.327, p = 0.016; for VAT: r=—0.304, p = 0.024).

Conclusion. The expression level of FABP4 gene in AT can act as a marker of AT dysfunction in obesity.
Morphological features of complicated gastroduodenal ulcers
Authors: Osmanov Z. H. , Rybakova M. G. , Tikhonova Yu. A. , Semenov D. Ju. , Korolkov A. Yu. , Mylnikova A. A.
Published: July 2022

The objective of the study was to evaluate structural changes in the margin of gastroduodenal ulcers complicated by perforation, bleeding or penetration in terms of the features of ulcer healing.

Methods and materials. Histological and IHC studies were performed on 25 patients of the main group with perforated gastroduodenal ulcers and 23 patients of the control group with chronic recurrent ulcers complicated by bleeding and penetration. Histological sections were stained with hematoxylin and eosin, and Van Gieson's picrofuchsin. Immunohistochemical reactions were performed with antibodies to Ki-67, CD68, CD138, and CD34.

Results. On macroscopic evaluation, a clear even margin of the perforation was noted. Histological examination with the background of acute dyscirculatory changes clearly shows a zone of necrosis and a weakly expressed layer of granulation tissue, which in majority of the cases was practically absent. The margin of a perforated ulcer consists of a minimally presented, clearly delimited zone of tissue detritus and a practically unchanged muscle layer. Plasma cells dominated in the cell infiltrate, and the index of proliferative activity in the epithelium of the ulcer margins was about 45 %, distributed fairly evenly.

Conclusions. Perforated ulcers can be considered as a special group of ulcers with the most pronounced changes of infiltration by plasmatic cells and eosinophils, edema and acute dyscirculatory changes, uniform and fairly high proliferative activity of the epithelium. Changes in the margins of the perforated ulcer allow for complete regeneration without excessive scarring with precise suturing of the perforation.
Reasons for not prescribing anticoagulants in hospitalized patients with atrial fibrillation and high risk of stroke: what should be the optimal management tactics for these patients?
Authors: Baranova E. I. , Bliznyuk O. I. , Pavlova V. A. , Skuridin D. S. , Kolesnik O. S. , Katsap A. A.
Published: July 2022

The objective of our study was to determine the reasons for not prescribing anticoagulant therapy (ACT) in the therapeutic department of university clinic for patients with atrial fibrillation (AF) and a high risk of stroke and to discuss the optimal management of these patients.

Methods and materials. A retrospective analysis of 1307 case histories of AF patients admitted to a university therapeutic clinic from 2014 to 2018 presented. The reasons for not prescribing ACT to patients with AF and high risk of stroke and optimal ACT discussed.

Results. ACT was not prescribed to 109 (9.7 %) hospitalized patients out of 1128 patients with AF without prosthetic valves and mitral stenosis who had a high risk of stroke ((4.5±1.1) points on the CHA2DS2VASc scale). The risk of bleeding – (1.6±0.1) (HAS-BLED). The age of patients was (73.8±10.4) years. From 2014 to 2018, the frequency of unjustified non-prescribing ACT decreased by 3.7 times – from 47/205 (22.9 %) in 2014 to 11/178 (6.2 %) in 2018 (p=0.001). In general, over 5 years of observations, subjective reasons for not prescribing ACT were: lack of stroke risk assessment (78.0 %), senile age of patients and the presence of dementia (42.2 %), the first paroxysm of AF (22.9 %) during myocardial infarction and heart surgery, planned surgical treatment, effective radiofrequency ablation and patient refusal. Objective (usually transient) reasons for not prescribing ACT were: severe and moderate anemia (24.8 %), recent bleeding (11.9 %), gastrointestinal diseases predisposing to bleedings (9.2 %), oncology (12.8 %), end-stage chronic kidney disease (2.8 %), thrombocytopenia (2.8 %). Often various reasons for not prescribing ACT were combined.

Conclusion. In patients with AF and a high risk of stroke, the incidence of not prescribing ACT decreased by 3.7 times from 2014 to 2018. In 2014, the most common reasons for not prescribing ACT were the lack of stroke risk assessment and the senile age of patients, and in 2017–2018 senile age, the first paroxysm of AF, effective radiofrequency ablation, anemia, recent bleeding, and gastrointestinal diseases predisposing to bleedings.
Use of intangible assets: Theoretical and applied aspects
Authors: STRIZHAKOVA Ekaterina N. , STRIZHAKOV Dmitrii V.
Published: July 2022

Subject. The article addresses the use of intangible assets in the economic activities of enterprises, possibility and feasibility of leasing model use in this process.
Objectives. The focus is on the analysis of intangible asset efficiency, analysis of the concept of ‘intangible assets’, taking into account existing standards, regulations, laws, and other regulatory documents in Russia and other countries of the world.
Methods. The analysis of the main elements that make up intangible assets, methods of their evaluation, leasing as a form of financial services, as well as the feasibility of using it for intangible assets is performed, using methods of abstraction, classification, synthesis, induction, deduction and formalization.
Results. We critically reviewed the existing viewpoints on the analyzed problem, demonstrated possible difficulties and potential solutions to emerging problems. The paper establishes that competitiveness of enterprises depends on the degree of using new, innovative management methods and resource utilization. One of the main directions is to increase the efficiency of the use of intangible resources.
Conclusions. Innovative development is closely related to the use of intangible assets, so all possible ways should be applied to intensify this direction. Such a type of financial services as leasing allows enterprises to have significant competitive advantage. However, in the Russian Federation, it can be used only for tangible resources, while foreign companies are successfully implementing it for intangible resources.
China's accounting regulatory regime and its structure
Authors: HONGYING LYU
Published: July 2022

Subject. This article deals with the issues related to the accounting regulatory system of China, considering its main components and structural features.
Objectives. The article aims to present the characteristics of the accounting regulatory system of China and analyze its composition horizontally and vertically.
Methods. For the study, I used analysis, synthesis, and other general scientific methods.
Conclusions. The article notes that the accounting regulatory system of China can be divided vertically into four levels according to powers and legal force, and horizontally, four aspects of it can be distinguished in accordance with the content of the accounting rules.
Risk forecasting for the Russian economic sectors in the context of sanctions ramp-up
Authors: ABRAMCHIKOVA Natal'ya V.
Published: July 2022

Subject. This article discusses the problems of the Russian economy stabilization and the international sanctions' peculiarities.
Objectives. The article aims to define the forecast net foreign assets measure value impact on the level of financial risk for the Russian economy.
Methods. For the study, I used a statistical analysis including the time series extrapolation method.
Results. The article reveals that industries with a low percentage of import substitution are at the greatest risk if the sanctions ramp up. The article also confirms a steady downward trend in the net foreign assets value, which causes instability of the national currency exchange rate.
Conclusions. Almost all sectors of the Russian economy are at risk of destabilization. The functioning of the economy in difficult conditions depends on the cohesion of the Government and business.
Anti-erosion conservation and its economic efficiency
Authors: KHISMATULLIN Marsel' M. , KHISMATULLIN Mars M. , VALIEV Airat R. , LUKMANOV Anas A. , ULLAH Raheem
Published: July 2022

Subject. This article analyzes the efficiency of agricultural production in the context of globalization of agricultural raw materials and food markets.
Objectives. The article aims to analyze the impact of land erosion on the efficiency of agricultural production.
Methods. For the study, we used the case-study, abstract-logical, computational-constructive, and statistical analysis methods.
Results. The article presents the results of the analysis of land degradation in the Republic of Tatarstan, identifies priority areas for controlling erosion processes in agriculture, and experimentally substantiates measures to control land erosion.
Conclusions. The implementation of the proposed measures can contribute to the development of the agro-industrial complex and other sectors of the economy.
The organizational and economic particularities and evaluation of green innovation
Authors: LAGUTENKOV Aleksei A. , DUBOLAZOVA Yuliya A.
Published: July 2022

Subject. This article discusses the issues of improving the efficiency of production and economic activities and environmental protection.
Objectives. The article aims to find tools for the transformation of the modern socio-economic system in the context of the transition to the principles and standards of the green economy.
Methods. For the study, we used a statistical analysis, generalization, modeling, and classification.
Results. Based on the analysis, the article evaluates modern methodological approaches to determining the essence of green innovation technologies.
Conclusions. There is a need to formulate a clear regulatory definition of the term Green Innovation at the federal and regional levels.
An Eye on the Brain: Insights from the Eye Determinants of Cognition Study
Authors:   Johns Hopkins University, AG Abraham
Published: July 2022

Blindness and visual impairment are leading causes of disability and reduced quality of life in older adults, affecting more than 11% of people aged 50 years and older in the general population [1]. The global burden will only grow as populations around the world age [1,2].
Blockchain: Funcionamiento y pertinencia en sectores públicos y privados
Authors: Reyes Sánchez Carlos
Published: July 2022

La primera y más emblemática aplicación de la tecnología blockchain es la criptomoneda denominada bitcoin, que tiene un valor de mercado superior a un billón de dólares y es aceptada como moneda de cambio en múltiples comercios. Sin embargo, actualmente existen muchas y muy diversas aplicaciones de blockchain ajenas al mercado financiero. El objetivo del artículo es presentar una descripción de los principales componentes de blockchain, a fin de que los lectores tengan elementos técnicos que les permitan introducirse en el campo de las tecnologías distribuidas y sus posibles aplicaciones, destacando la existencia de un sinfín de industrias y sectores, en donde empresas y gobiernos están utilizando esta tecnología para mejorar sus procesos y resultados.
Chatbots como Apoyo a Tutorías Académicas en la Licenciatura en Sistemas Computacionales Administrativos de la Universidad Veracruzana Región Xalapa
Authors: Ortiz Hernández Gustavo , Galindo Monfil Alma Rosa , Martínez Herrera Brenda Marina , Gálvez Vázquez Miguel Ángel
Published: July 2022

Las tutorías en la Universidad Veracruzana son un instrumento fundamental para el apoyo y acompañamiento de los estudiantes en su vida académica. La contingencia por el virus SARS-CoV-2 impactó todos los ámbitos, incluyendo el educativo y puso en boga el uso de las Tecnologías de la Información y Comunicación. Particularmente, la Inteligencia Artificial, cuya aplicación se ha notado de manera significativa en el uso de chatbots, puede ser una herramienta conveniente para apoyar en la actividad de tutorías, mientras se mejoran indicadores como disponibilidad, nivel de conocimiento, tiempo y calidad de respuesta. Éste trabajo expone el desarrollo, implementación y evaluación de un chatbot como apoyo a las tutorías académicas de la Licenciatura en Sistemas Computacionales Administrativos de la Facultad de Contaduría y Administración de la Universidad Veracruzana.
Aplicación de Modelos de Economía Circular en México y Colombia: Estudio de caso
Authors: Gutiérrez León Rosa Isela
Published: July 2022

El objetivo del presente artículo es analizar los factores y actores que intervienen en la transición de un modelo de economía lineal a uno circular aplicado en los negocios, así como los impactos que genera en una nación. La investigación tuvo un enfoque cualitativo, la muestra seleccionada consta de dos empresas: Disparate de Colombia y Ecopipo de México. Los resultados arrojan que la iniciativa de emprender bajo este esquema fue la preocupación medioambiental, además de la necesidad de generar ingresos, igualmente se constata que los cambios por parte del consumidor como de las políticas públicas surgen a partir de la crisis medioambiental y sanitaria.
Experiencias emprendedoras internacionales Colombia - México
Authors: Guzmán Coutiño Héctor , Martínez Herrera Brenda Marina , Olier Restrepo Juan Carlos , Ortiz Cano Gloria Cristina , Pulistar Beatriz Jackeline , Velásquez Agudelo Natalia
Published: July 2022

El presente artículo es producto del desarrollo de Primera Feria Internacional de emprendimiento “Un encuentro de ideas para el desarrollo sostenible”, promovido a través de convenios interinstitucionales entre las instituciones IU Digital de Antioquia, Incubadora de Empresas Génesis por Colombia, la Cámara de Comercio de Medellín para Antioquia y Universidad Veracruzana México, con el objetivo de Impulsar el desarrollo del emprendimiento, como el pilar fundamental de la cultura empresarial establecida por las cuatro instituciones.Teniendo en cuenta que el emprendimiento es un tema del ámbito global en el cual las instituciones se han comprometido para promover y desarrollar una cultura emprendedora, a través de la feria se hicieron visibles la experiencia de docentes y las iniciativas de los estudiantes posibilitando espacios de encuentros académicos y fortaleciendo el proceso emprendedor.
Por lo anterior, se expone la importancia del emprendimiento como generador de desarrollo económico, para el mejoramiento de calidad de vida de la población, acordes con los Objetivos de desarrollo sostenible.
Epstein-Barr virus associated with dermatopolymyositis: a case report
Authors: Fernandes Ana Clara , Brilhante Neto Francisco , Aragão Laura , Queiroz Cítara , Vieira Maria , Moura Anaís
Published: July 2022

INTRODUCTION: The Epstein-Barr virus (EBV) is a DNA virus of the Herpesviridae family, which exists in the latent form in 95% of the world population. This virus infects the B lymphocytes, which promotes a persistent infection with periodic reactivations. EBV is probably a strong environmental factor in etiology of autoimmune diseases, once its viral proteins are involved in altering the host’s immune system, causing loss of self-tolerance and development of neoplasms. OBJECTIVE: To report a case of a patient with EBV associated with the development of dermatopolymyositis. CASE REPORT: Girl, 5 years, presenting erythematous-scaly lesions in extending region in upper and lower limbs. During follow-up, the patient’s mother returns referring worsening of the child, complaining of periodic fever, infection of upper airways and worsening of the lesions associated with difficulty of ambulation as well as difficulty of sitting in the past three weeks. Physical examination showed pharyngotonsillitis, cervical, axillary and inguinal adenomegalies and hepatomegaly. The limbs skin presented scaly and pruritic erythematous macules as well as on the metacarpophalangeal and interphalangeal joints, weakness of the pelvic muscles and arthralgia in the knees and ankles. After undergoing muscle biopsy, it presented a pattern for dermatopolymyositis, and imunosupression was initiated with methotrexate. Therefore, the patient improved clinically and laboratory regarding mononucleosis and the symptoms of dermatopolymyositis. The patient continues in specialized treatment and motor physiotherapy. CONCLUSION: Attention should be payed to the influence of viral component, such as the Epstein-Barr virus, on the pathogenesis of dermatopolymyositis in individuals genetically predisposed to autoimmune diseases.
Langerhans cell histiocytosis with isolated cutaneous involvement
Authors: Campos Luana , Amorim Vanessa , Malzoni Maria , Haddad Gabriela
Published: July 2022

A 14-year-old white female patient with allergic rhinitis, reported a 4-week history of pruritic, lichenoid and erythematous papules and plaques involving first cervical region and after throughout the body. The histopathology was indicative of Langerhans cell histiocytosis. Laboratory and imaging tests showed no impairment of other organs. Lesions regressed after oral prednisone for 2 months. Currently, the patient remains asymptomatic without medication. We highlight the rarity of this disease and the importance of its early recognition. It is extremely important to maintain periodic follow-up to evaluate possible recurrences.
Checklist for pediatric patient dehospitalization with complex chronic condition interned in the Unified Health System
Authors: Petta Renata , Silva Daniela , Gonzaga Ana , Rusu Joyce , Ferreira Karollini
Published: July 2022

Nowadays, pediatric intensive care units are overwhelmed and full with clinically stable patients; however, chronically dependent on medical technologies. These are known as carriers of complex chronic condition. As a way of humanizing care, minimizing complications and reducing hospital expenditure, dehospitalization has been occurring earlier and more frequently. Meantime, there is no standardization in the process, which can cause failures that can be minimized through concrete and well-established actions. Therefore, this study objective was to develop a checklist for the dehospitalization of pediatric patients admitted to the Unified Health System with complex chronic condition, to help healthcare professionals to consider the possibility of safe discharge. A literature review was conducted from February to August of 2019 for the construction of the checklists theoretical background. Articles available in the health database (PEDro, PubMed, and LILACS) were included, using the following descriptors: patient discharge, chronic disease and pediatrics, dated from the year 2005 and with full text available. Simple literature reviews and articles referring to the adult population were excluded. It was developed a checklist describing the performance of each professional in the dehospitalization process. It was possible to verify the importance of health professionals in working integrated and through the delimited flows instruct family members/caregivers in order to enable the pediatric patient a safer hospital discharge and prevent early readmissions.
Case report: primary ciliary dyskinesia associated with Kartagener syndrome
Authors: Faria Mariana , Matos Giulia , Costa Tiago , Sobral Larissa , Chagas Isabella
Published: July 2022

INTRODUCTION: Primary ciliary dyskinesia is a ciliary mobility disorder, which is characterized by reduced or uncoordinated mobility of the cilia present in the respiratory epithelium. Consequently, mucociliary transport is impaired in the patient’s respiratory tract, making him susceptible to infections and stasis of recurrent secretions, and later to a hyperplasia of secretory cells. CASE REPORT: This article describes the case of a patient with primary ciliary dyskinesia associated with Kartagener syndrome. All the significant points that led to its early diagnosis (less than 3 years of age) will be highlighted, including clinical status, imaging tests, and genetic study. DISCUSSION: It is an autosomal recessive disease, and in half of the cases it is associated with Kartagener syndrome, which manifests classic signs of chronic sinusitis, situs inversus and bronchiectasis. Furthermore, it is also common to find persistent cough, dyspnea, otitis media, mouth breathing, nasal polyp, and even cardiac malformations in patients with the disease. The differential diagnosis for ciliary dyskinesia is important in order to investigate possible additional damage to the patient due to his clinical condition. Therefore, clinical investigation in conjunction with radiographs, CT scans and cytological exams are the main method for analyzing structural variations. Overall, this dysfunction is usually identified in late stages, so its study is necessary enough to help the early diagnosis of the pathology, contributing to the preservation of the pulmonary function of these patients.
Spontaneous deviation from primary care to medium and high complexity care in pediatrics
Authors: Souza Anna Carolina , Santos Letícia , Zintl Karen , Zollner Ana Cristina , Constantino Clóvis
Published: July 2022

INTRODUCTION: Primary health care is a set of interventions that promotes initial contact with the health system, whereas those of medium and high complexity include hospitals, outpatient clinics, urgent and emergency services, exams and procedures. Lately, there has been a phenomenon of voluntary diversion from primary care to medium and high complexity care in pediatrics. OBJECTIVE: To present some reasons why the aforementioned phenomenon occurs, its consequences, and to cite intervention proposals taken to reverse this. METHODS: A literary review was carried out on the topic of articles found in databases, such as LILACS, BIREME and PubMed. DISCUSSION: This spontaneous deviation has, among its various causes, notions such as easier access, convenience and faster resolution in emergency services or even the lack of perception of what is an urgency. In addition, it is believed that parents prefer emergency care because they find a greater variety of specialties and, consequently, greater resolution, in one place. CONCLUSION: The substitution for medium and high complexity care has had repercussions not only for the child’s health, but also for the health system itself. Therefore, urgent and emergency services are not used as they should and do not have the capacity to meet the needs of their patients, given that the complaints prioritized in these services are acute, and many diagnoses that could be made through a longitudinal monitoring is not done due to the need for immediate resolution.
Avoidant restrictive food intake disorder: what is the eating disorder?
Authors: Almeida Mariana , Moreira Luiza , Leahy Rachel
Published: July 2022

INTRODUCTION: Avoidant restrictive food intake disorder (ARFID) is a relatively new diagnostic category introduced in the medical literature in 2013 in the DSM-V. It includes individuals who exhibit abnormal eating behavior that may or may not lead to weight loss, but which undoubtedly leads to compromised quality of life. Causes for this behavior include patients who do not eat out of fear, neurosensory issues, and/or lack of appetite. OBJECTIVES: Make a review of which is ARFID. METHODS: Integrative review of the literature on the subject in PubMed and from there, searching for additional material from the references. 30 sources were evaluated among books and published articles. CONCLUSION: The main differential diagnosis to be made is with early onset anorexia nervosa. The treatment is not well established, but there are behavioral and drug interventions that have been studied.
Para Politikası Uygulamalarının Gelişmekte Olan Ülkelerin Ülke Kredi Riski Üzerindeki Yayılma Etkisi
Authors: DURAL Fatma , SEÇME Zekeriya Oğuz
Published: July 2022

Finansal serbestleşme ve uluslararası finansal entegrasyonla birlikte ülkelerin finansal piyasaları arasındaki etkileşim artmıştır. Bu etkileşim neticesinde, dünyada para politikası kararları da gelişmiş ülke merkez bankalarının kararları doğrultusunda şekillenmekte ve diğer ülkeler tarafından FED (Federal Rezerv- Merkez Bankaları Sistemi) ve ECB(European Central Bank -Avrupa Merkez Bankası) kararları yakından takip edilmektedir. Bu çalışmada FED ve ECB para politikası kararlarının gelişmekte olan ülke kredi temerrüt swapları üzerindeki etkisi araştırılmaktadır. Bu amaçla politika faiz oranları ile birlikte küresel risk ve likidite göstergeleri, VIX ( (Volatility Index- Volatilite Endeksi) ve TED Spread (Treasury-EuroDollar Spread) analize dahil edilmiştir. Çalışma 2005-2020 arası dönemde aylık verilerle GARCH (Generalized AutoRegressive Conditional Heteroscedasticity-Genelleştirilmiş Otoregresif Koşullu Değişen Varyans) modeli kullanılarak yapılmıştır. Çalışma sonuçlarına göre gelişmekte olan ülke kategorisindeki Türkiye ve Polonya benzer sonuçlar vermektedir. FED ve ECB faiz oranları ile “TED spread”deki bir şok etkisinin Türkiye ve Polonya kredi temerrüt swapları (CDS) primlerini etkilediği gözlemlenmiştir. Bununla birlikte Rusya ve Güney Kore örneklerinde ise FED, ECB, TED spread veya VIX endekslerinde meydana gelen herhangi bir değişikliğin bu ülkelerin CDS (Credit Default Swap- Kredi Temerrüt Riski) primlerini etkilemediği sonucuna ulaşılmıştır.
Borsa İstanbul (BIST) Metal Eşya, Makine ve Gereç Yapım Alt Sektöründe Firma Performansına Yatırım Faaliyetlerinden Kaynaklanan Nakit Akışlarının Etkisinin Panel Veri Analizi ile Araştırılması
Authors: TOPAL Bora , ELMAS Bekir
Published: July 2022

Bu çalışmanın amacı Borsa İstanbul (BIST) Metal Eşya, Makine ve Gereç Yapım alt sektöründe faaliyet gösteren firmaların performanslarına, yatırım faaliyetlerinden kaynaklanan nakit akışlarının bir etkisinin olup olmadığını tespit etmektir. Bu amaçla; 2008-2018 dönemindeki yıllık veriler kullanılarak yapılan araştırmada, firma performansının temsili için üç model oluşturulmuş ve oluşturulan modeller panel veri analizi yöntemi kullanılarak analiz edilmiştir. Analiz sonuçlarında göre ilgili dönemde yatırım faaliyetlerinden kaynaklanan nakit akışlarının, firma performansına etkisi “Varlıkların Kârlılığı” modelinde pozitif, “Varlıklardaki Büyüme” modelinde negatif ve “Hasılattaki Büyüme” modelinde ise anlamsız olarak tespit edilmiş olsa da analiz sonuçları genel olarak değerlendirildiğinde anlamlı bir etkinin bulunmadığı sonucuna ulaşılmıştır. Bu sonuçlar da ilgili dönemde firmaların, yatırım faaliyetlerinden kaynaklanan nakit akışlarının, firma performansları üzerinde direkt bir ilişkisinin bulunmadığını ortaya koymuştur.
Kurumsal Sürdürülebilirlik Performansının Entropi Ve TOPSİS Yöntemleriyle Ölçülmesi: BIST Şirketleri Üzerine Bir Uygulama
Authors: ÖZEVİN Onur
Published: July 2022

Şirketlerin sürdürülebilirliğe katkıları paydaşlar tarafından önemsenen ve dolayısıyla şirketin finansal performansını doğrudan etkileyen bir konudur. Bu çalışmanın amacı şirketlerin çevresel, sosyal ve ekonomik olmak üzere üç boyuttan oluşan kurumsal sürdürülebilirlik performanslarının ölçülmesidir. Diger bir ifadeyle, hangi kriterlerin sürdürülebilirlik performasında ne derece etkili olduğunu ve bu kriterlere göre hangi şirketlerin kurumsal sürdürülebilirlik performansı açısından daha başarılı olduğunu belirlemektir. Bu amacla firmaların sürdürülebilirlik performansını ölçmek için dört çevresel, dört sosyal ve dört finansal performans kriteri belirlenmiş ve bu kriterler bütünleşik Entropi – TOPSİS yöntemiyle analiz edilmiştir. Entropi yöntemiyle kriterlerin sürdürülebilirlik performansındaki önem ağırlıkları hesaplanmış, ikinci aşamada TOPSİS yöntemiyle bu kriterlere göre firmaların kurumsal sürdürülebilirlik performans başarı sıralamaları oluşturulmuştur. Çalışma veri kısıtlılığı nedeniyle BIST sürdürülebilirlik endeksinde yer alan 12 şirketin 2017, 2018 ve 2019yılı verileriyle sınırlıdır. Analiz sonuçlarına göre sürdürülebilirlik performansında ortalama olarak, çevresel kriterler %26, sosyal kriterler yüzde %32, finansal kriterler ise %42 etkilidir. Analiz sonuçları sosyal ve çevresel kriterlerin, kurumsal sürdürülebilirlik performansında toplamda %58 önem ağırlığına sahip olduğu göstermektedir. Bu durum şirketlerin başarı ve performansında finansal performans yanında sosyal ve çevresel performansın da ihmal edilemeyecek derecede önemli olduğunu göstermektedir.
Load Reduction During Resonance Crossing of a Variable-Speed Rotor
Authors: Chandrasekaran Ruthvik , Hodges Dewey H.
Published: July 2022

The efficiency of the rotorcraft could be improved significantly by varying the speed of the rotor based on the flight condition. Due to this reason, variable-speed rotor (VSR) technology is becoming popular, especially among urban air mobility vehicles. However, one of the biggest challenges of a VSR is the vibration of the rotor blade when it passes through a resonance point. A detailed study on the characterization of these resonances was performed by the authors (“Performance Advantages and Resonance Analysis of a Variable Speed Rotor Using Geometrically Exact Beam Formulations,” Journal of American Helicopter Society, Vol. 67, May 2022, Paper 042006). In this study, methods of reducing loads during resonance crossings are explored. The rotor model is built in Dymore, which is a multibody dynamics simulation tool. The geometrically exact beam theory is used to model the rotor blades as one-dimensional beams. Peters et al.’s (“Finite State Induced Flow Models Part I: Two-Dimensional Thin Airfoil,” Journal of Aircraft, Vol. 32, No. 2, March–April 1995, pp. 313–322) unsteady aerodynamics model with finite-state inflow and dynamic stall is used to obtain the aerodynamic loads acting on the rotor. Load reduction studies were carried out by varying the transition time, structural damping, and lag stiffness of the blade. The longer the rotor took to traverse a resonance region, the greater were the resonance loads. However, there were torque limitations on how quickly a rotor could pass through resonance. Increasing the structural damping was a very effective way of reducing the resonance loads. Increasing the lag stiffness of the rotor blade deteriorated the torque response due to 4/rev crossings. Combination studies were performed by combining the ideal transition times with 7% lag damping.
Use of the innovative model «flipped classroom» at foreign language classes at a non-linguistic university
Authors:   State Fire Academy of EMERCOM of Russia, MUZYCHENKO Anna S. , SKURKO Elizaveta M. ,   State Fire Academy of EMERCOM of Russia
Published: July 2022

The possibilities of using the innovative technology "flipped classroom" in teaching a foreign language at a technical university are considered in the given article. The authors describe the advantages of this method such as: increasing the time dedicated to the development of students' communicative competencies, incorporating them into an active cognitive activity, developing the students’ independence. They also analyze the shortcomings and difficulties, which primarily relate to a significant increase in the time spent by the teacher on preparing materials when implementing this technology, as well as on learning new tools.
Analysing new social phenomenon – algocracy
Authors:   State Fire Academy of EMERCOM of Russia, FURS Svetlana P.
Published: July 2022

The article discusses the key aspects of algocracy spread in society and also reveals the essential features of this phenomenon. The possibilities for algorithmic mechanisms within the framework of the bureaucratic model according to M. Weber are shown.
The role of artillery in the course of counterattack of the Soviet troops near Moscow on the example of the 1941 Kalinin offensive operation
Authors:   State Fire Academy of EMERCOM of Russia, ASHCHEULOV Oleg E.
Published: July 2022

Based on archival materials from the Central Archive of the Ministry of Defense (CAMD) of the Russian Federation and memoirs, the article considers the composition, role and combat use of artillery of the Kalinin Front during the Kalinin offensive operation of 1941. Data are given on the quantitative and qualitative composition of the Kalinin Front artillery, the features of its combat use are analyzed, and the contribution of artillery to the victory of the Soviet troops in the battle of Moscow is revealed.
Josef schumpeter’s concept as an example of interdisciplinary approach development within social knowledge framework
Authors:   State Fire Academy of EMERCOM of Russia, FURS Svetlana P. , FEDOSEEV Aleksey A. ,   State Fire Academy of EMERCOM of Russia
Published: July 2022

The article considers Austrian economist and social thinker J. Schumpeter’s main ideas, as well as his survey methodology features. Emphasis is placed on the interdisciplinary nature of the economic analysis algorithm developed by him; the scientist’s intention to create an integrated social knowledge is shown.
The activity of A. I. Chernyshev in 1825–1852: from the Investigative Committee to the Ministry of War
Authors:   State Fire Academy of EMERCOM of Russia, KOTLYAREVICH Aleksander N.
Published: July 2022

The article analyzes the civil service of Alexander Ivanovich Chernyshev as head of the investigation team in the case of the Decembrists and the Minister of War of Russia. Particular attention is paid to his personal and professional qualities which made it possible to equally successfully solve tasks so different in time, scale and level, to overcome existing and potential contradictions.
The safety and efficacy of closed reduction and percutaneous pinning with an intraoperative arthrogram for Grade 2 and Grade 3 pediatric lateral condyle fractures
Authors: Al-Naseem Abdulrahman , Al-Shehawy Haytham M. , Khaja Aliaa F. , Awad Mohammad , Hammady Wael K. , Alkandari Asmaa , Nasri Tareq , Al-Saifi Saleh
Published: July 2022

Objectives:

It is controversial whether pediatric lateral humeral condyle fractures (LHCFs) with >2 mm displacement can be managed using closed reduction and percutaneous pinning (CRPP) as opposed to open reduction. This study assesses the clinical, radiographic outcomes, and complication rates of patients undergoing arthrogram-assisted CRPP for fractures with >2 mm of displacement rather than open reduction and internal fixation.

Methods:

This study was conducted retrospectively, looking at all children presenting acutely with LHCFs that were displaced >2 mm between January 2017 and December 2019 whom one surgeon treated within 48 hours of the initial injury. Sixteen patients met the inclusion criteria. Pre-operative and post-operative anteroposterior as well as lateral radiographs were used to measure displacement and classify fractures. A subgroup analysis was done to compare the results in Grade 2 and 3 fractures as per Weiss classification.

Results:

Signs of union were observed in all patients at 2 weeks and all fractures were healing well at 6-week follow-up, regardless of fracture grade or displacement. Post-operative complications including pin site infections, valgus deformity, non-union, or malunion were not seen. A higher proportion of Grade 3 patients developed heterotrophic ossification and limitation of range of movement.

Conclusion:

Arthrogram imaging is a valuable tool to help visualize the articular cartilage surface and determine the suitability of CRPP for LHCF with >2 mm displacement. It is a safe option with good outcomes and provided that there is no significant articular cartilage incongruity seen under fluoroscopy.
Concept maps as dynamic tools to increase students' understanding of knowledge and creative thinking
Authors: Kusumadewi Rida Fironika , Kusmaryono Imam
Published: July 2022

Concept maps are closely related to students' understanding of knowledge and creative thinking skills. This study aims to determine the effectiveness of concept maps as in increasing understanding of knowledge and creative thinking skills when students are involved in learning activities. The type of research method chosen is descriptive analysis. Research data were collected through (1) questionnaires, (2) concept map assessment rubrics, and (3) interviews. The results of the questionnaire were evaluated using the percentage technique. Students' answers to open-ended questions about the advantages and disadvantages of applying concept maps are summarized and analyzed descriptively. The results showed that most respondents stated that learning with concept maps was fully effective. Analysis of answers to questionnaires and open-ended questions cloncludes that concept maps are effective as a tool to improve students' understanding of knowledge and creative thinking skills that have implications for meaningful learning, student positive attitudes, and student academic achievement.
Development of learning trajectory of perimeter and area of squares and rectangles through various tasks
Authors: Kurniawati Labibah , Amir Mohammad Faizal
Published: July 2022

Learning trajectory on the topic of plane figures (i.e., perimeter and area of squares and rectangles) is necessary for elementary students to facilitate meaningful learning and predict their learning progress. This study aims to develop a learning trajectory through various tasks for the perimeter and area of squares and rectangles that can help students develop understanding and construct mathematical concepts. Study participants were fourth grade elementary students. The method used was design research, which has three stages: preparing for the experiment, teaching, and retrospective analysis. This study used data collection instruments in worksheets, observation sheets, interview guidelines, and field notes. Research results obtained included a learning trajectory that contains adequate learning activities to facilitate learning for elementary students on the perimeter and area of squares and rectangles. Adequate learning trajectory is obtained in hypothetical learning trajectory (HLT) 2, which was previously revised from HLT 1. Learning trajectory developed through a variety of tasks can significantly construct and facilitate elementary students’ knowledge to learn the concepts of perimeter and area of squares and rectangles.