bluuebunny/crossref_metadata_2025 huggingface dataset:
Age-related features of the main risk factors and clinical and laboratory parameters in men aged 30–50 years with atherothrombotic stroke
Authors: Pizov N. A.
Published: November 2024

Introduction. Ischemic stroke in patients under 50 years of age is not uncommon. The prevalence of stroke in young people increases due to the increase in risk factors. Early detection of risk factors and optimization of primary and secondary preventive therapy are mandatory to reduce the burden of stroke in young people and preserve potential years of life.

Objective. To identify and evaluate the main risk factors and clinical and laboratory parameters in men aged 31–40 and 41–50 years with atherothrombotic stroke.

Material and methods. Before the development of the COVID-19 pandemic, 60 patients were examined (mean age 43.3±3.8 years). All patients underwent neuroimaging of the brain, ultrasound examination of the main vessels of the head, echocardiography, ECG, and laboratory analysis of blood serum.

Results. Among all patients, there were 10 patients aged 31–40 years (mean age 37.4±2.6 years) and 50 patients aged 41–50 years (mean age 44.5±2.8 years). All patients had atherosclerotic lesions of the main arteries of the head, with stenosis of more than 70 % only in patients aged 41–50 years. Among patients aged 31–40 years and 41–50 years, the most common risk factors were arterial hypertension (90 and 72 %), smoking (70 and 72 %), dyslipidemia (66.7 and 60 %), and regular alcohol consumption (30 and 36 %). The study showed statistically significant correlations of the main vascular risk factors with serum lipid metabolism indices, hemostasis and endothelial dysfunction markers.

Conclusions. The study showed the frequency of occurrence of the main risk factors in patients with atherothrombotic stroke aged 31–40 and 41–50 years, as well as the role of lipid metabolism disorders, hemostasis disorders and endothelial dysfunction in their development.
The effectiveness of antidepressant therapy against anhedonia in patients with alcohol dependence
Authors: Khizhnyak D. G. , Barylnik Yu. B. , Makaryan E. S. , Gildebrant A. V. , Aredakov K. G.
Published: November 2024

The article presents the results of a scientific study aimed at determining the effectiveness of the drug Vortioxetine (Brintellix) in the treatment of affective spectrum disorders in patients with alcohol dependence in a drug treatment hospital, since the drug is promising for widespread use in the drug therapy of a number of mental disorders and in the future could be included in the standard of medical care in the field of psychiatry-addictology. It is known that anhedonia is one of the mental disorders in withdrawal syndrome, which provokes relapses of an addictive disorder and negatively affects the duration and quality of remissions of patients with an addiction profile. At the same time, the study of antidepressant therapy in the treatment of alcohol dependence remains relevant, since poor tolerance, side effects, and deterioration of the patient's general condition may affect adherence to drug therapy. In the present study, anhedonia was assessed on the Snaith-Hamilton SHAPS scale, anxiety-depressive manifestations using the HADS hospital anxiety and depression scale and quality of life according to the SF-36 questionnaire during 24 weeks of follow-up.

The result of drug therapy with Vortioxetine was the relief of affective disorders in alcohol dependence, which contributed to the improvement of overall subjective well-being, the degree of satisfaction with the quality of life and a decrease in anxiety-depressive tendencies and anhedonia. In addition, minimal and minor adverse reactions when taking Vortioxetine affected the increased adherence of the examined patients to medical prescriptions and recommendations.

Conclusions. The use of Vortioxetine in the treatment of affective disorders among patients suffering from alcohol dependence provides new opportunities to help people suffering from alcohol addiction. Vortioxetine can be recommended both at the stage of inpatient care and outpatient treatment, since when it was taken, stable positive dynamics of antidepressant, anti-anxiety and antiangedonic effects were recorded.
Pain syndrome, “dropped head” and myasthenia gravis: a case report and literature review
Authors: Merkulov Yu. A. , Plieva E. L. , Merkulova D. M.
Published: November 2024

The objective of the study is to present a description of the first domestic clinical observation of the painful dropped head syndrome in a patient with myasthenia gravis (MG).

Materials and Methods. Clinical, laboratory and instrumental data were analyzed over the course of MG symptoms with late onset in combination with thymoma, manifesting with pain and weakness in the neck extensors.

Results. The characteristic and unique features of diagnostics and treatment of MG developed in a 59-year-old patient associated with antecollis and significant pain syndrome, initially considered as manifestations of osteochondrosis, are observed in comparison with the literature data. The information on the occurrence, demographic origin, association with the type of receptor targets, thymus pathology and reversibility of these disorders in MG is systematized, and the importance of addressing the concepts of pain in MG is emphasized. The positive effect of ipidacrine in the symptomatic treatment of MG in a patient with marked cholinergic manifestations induced by conventional anticholinergic agents (AA) therapy is confirmed.

Conclusions. MG can cause axial muscle impairment leading to the phenomenon of “dropped head” and the development of pain syndrome atypical for the classical course of the disease. Pathogenetic treatment of seropositive MG in most cases leads to the elimination of its clinical manifestations, including pain. In some cases, the use of the reversible AA ipidacrine is an additional advantage in the therapy of such conditions, taking into account its concomitant proven efficacy as an adjuvant analgesic.
IDENTIFIKASI KESEGARAN DAGING AYAM MENGGUNAKAN METODE CONVOLUTIONAL NEURAL NETWORK
Authors: Zuhdi Muflih Roid , Setiawan Riezky Fauji , Saputro Bintang Ilhan Harjo
Published: November 2024

Penelitian ini bertujuan untuk mengidentifikasi kesegaran daging ayam berdasarkan citra menggunakan Convolutional Neural Network (CNN). Dalam industri pangan, penentuan kesegaran daging ayam secara cepat dan akurat sangat penting untuk memastikan kualitas produk dan keamanan konsumen. Metode CNN digunakan karena kemampuannya yang tinggi dalam ekstraksi fitur dan klasifikasi citra. Dataset citra daging ayam dikumpulkan dan diproses untuk melatih model CNN. Kami mengevaluasi performa model klasifikasi biner menggunakan kurva Receiver Operating Characteristic (ROC) dan nilai Area Under the Curve (AUC). Hasil menunjukkan nilai AUC sebesar 0,47, mengindikasikan performa klasifikasi yang kurang baik. Namun, evaluasi menggunakan F1-Score menunjukkan hasil yang sangat positif, dengan nilai F1-Score pelatihan sebesar 0,87 dan validasi sebesar 0,99. Ini mengindikasikan kemampuan prediksi yang kuat dan generalisasi yang baik dari model terhadap data yang tidak terlihat selama pelatihan. Hasil ini menunjukkan potensi penggunaan CNN dalam mengidentifikasi kesegaran daging ayam, meskipun diperlukan perbaikan lebih lanjut untuk meningkatkan performa klasifikasi biner yang diindikasikan oleh nilai AUC.
SISTEM PENDUKUNG KEPUTUSAN KENAIKAN GAJI KARYAWAN MENGGUNAKAN METODE TOPSIS BERBASIS WEB
Authors: Syaputra Wendy , Harman Rika
Published: November 2024

Penelitian ini, yang berjudul "Sistem Pendukung Keputusan Kenaikan Gaji Karyawan Menggunakan Metode TOPSIS Berbasis Web," mengatasi masalah ketidaktransparanan dan subjektivitas dalam menentukan kenaikan gaji karyawan di Bintang Moro. Penyesuaian gaji yang adil dan objektif sangat penting untuk mempertahankan dan memotivasi karyawan, serta memastikan keberlanjutan dan pertumbuhan perusahaan. Sistem pendukung keputusan (DSS) yang dirancang dalam penelitian ini menggunakan metode TOPSIS, yang diimplementasikan sebagai aplikasi berbasis web. Metode TOPSIS dipilih karena kemampuannya untuk merangking alternatif berdasarkan kedekatannya dengan solusi ideal, memastikan pengambilan keputusan yang objektif. Penelitian ini melibatkan pengumpulan data tentang kinerja karyawan dan kenaikan gaji selama tiga bulan terakhir di Bintang Moro. Data tersebut diproses menggunakan metode TOPSIS dan diintegrasikan ke dalam sistem berbasis web yang dikembangkan dengan PHP dan MySQL. Temuan menunjukkan bahwa DSS berbasis TOPSIS memberikan rekomendasi kenaikan gaji yang lebih objektif dan transparan. Sistem berbasis web juga memudahkan manajemen dalam memantau dan mengevaluasi kinerja karyawan dengan lebih efisien. Implementasi sistem ini mengarah pada keputusan gaji yang lebih adil, menciptakan lingkungan kerja yang positif. Penelitian ini memberikan kontribusi pada bidang tersebut dengan menawarkan solusi praktis untuk dukungan keputusan dalam manajemen gaji karyawan. Ini dapat menjadi referensi untuk mengembangkan sistem serupa di konteks organisasi lain.
EVALUASI DAN PERANCANGAN USER EXPERIENCE PADA APLIKASI COVE MENGGUNAKAN UX HONEYCOMB
Authors: Sejati Wiyar Wilujengning , Sibagariang Efifania , Setiawan Hermawan
Published: November 2024

Penelitian ini mengevaluasi aplikasi penyewaan hunian Cove menggunakan model UX Honeycomb untuk meningkatkan pengalaman pengguna. Cove menyediakan aplikasi layanan penyewaan hunian berupa indekos. Meskipun aplikasi Cove tersedia di berbagai platform, rating pengguna menunjukkan beberapa kekurangan. Melalui studi literatur dan penilaian UX dengan 15 responden, penelitian ini mengidentifikasi masalah dalam tujuh aspek penting UX: useful, usable, findable, credible, accessible, desirable, dan valuable. Setelah perbaikan desain yang meliputi fitur pemesanan langsung, sistem akun pengguna, rekomendasi properti, fitur chatbot, sistem rating properti, dan transparansi harga, hasil evaluasi menunjukkan peningkatan signifikan dalam kepuasan pengguna, dengan rata-rata nilai UX meningkat dari 3.63 menjadi 4.56. Temuan ini menegaskan bahwa perbaikan desain berdasarkan model UX Honeycomb dapat meningkatkan kepuasan dan pengalaman pengguna secara keseluruhan.
RANCANG BANGUN UI/UX APLIKASI E-COMMERCE BERBASIS FRAMEWORK CODEIGNITER MENGGUNAKAN MODEL LEAN USER EXPERIENCE
Authors: Tukino Tukino
Published: November 2024

In today's era, some people require more specialized marketplaces for selling items such as driving equipment or automotive-related products. Individuals need consignment services to sell their driving gear like helmets, driving jackets, and other related items. Many people face difficulties in finding suitable and secure storage spaces for their belongings. This study explores the rapid expansion of internet usage, which has spurred the emergence of new business models, notably online marketplaces for buying and selling goods. The research focuses on developing a simple yet effective online store platform, particularly tailored for sellers at the Indonesian Helmet Shop. Employing the prototype method, this research constructs the application through various modeling techniques including use case diagrams, class diagrams, activity diagrams, and sequence diagrams. The primary objective is to create a lightweight, web-based marketplace application that enhances the transaction process between consignment providers and consumers. Preliminary findings suggest that the application facilitates efficient user interactions and transactions. However, further development is required in the areas of user interface (UI) and user experience (UX) to ensure greater consumer satisfaction and engagement. This study underscores the potential of tailored digital solutions in optimizing e-commerce platforms, particularly in specialized market sectors.
FILSAFAT HUKUM DALAM PENYUSUNAN PERATURAN DAERAH
Authors: Rozi Mumuh M
Published: November 2024

Penerapan prinsip desentralisasi sebagai dasar berpijak penyelenggaraan pemerintahan daerah membangun konstelasi baru sistem otonomi daerah yang luas, nyata, dan bertanggung jawab yang memberikan hak dan wewenang kepada daerah otonom untuk mengatur dan mengurus sendiri urusan pemerintahan dan kepentingan masyarakat setempat sesuai dengan peraturan perundang-undangan. Penataan potensi-potensi daerah oleh Pemerintah Daerah yang diberikan hak untuk membentuk produk Peraturan Daerah (PERDA). Pembentukan peraturan bertujuan untuk mengakomodir kepentingan dan kebutuhan daerah dengan memperhatikan kepentingan masyarakat dengan pertimbangan keadilan (gerechtigkeit) disamping sebagai kepastian hukum (rechtssicherheit) dan kemanfaatan (zweckmassigkeit). Filsafat Hukum yang hakekat muatan materi Peraturan Daerah yang mengakomodir kepentingan masyarakat di daerah guna mencapai suatu kebahagiaan yang terbesar kepada masyarakat melalui aspek filosofis dalam pembentukan Peraturan Daerah (PERDA).
HUKUM DAN PERDAGANGAN INTERNASIONAL DALAM PERSPEKTIF TEORI
Authors: Ukas Ukas , Daria Daria , Husna Lenny
Published: November 2024

Perdagangan internasional merupakan salah satu bagian dari kegiatan ekonomi atau kegiatan bisnis yang akhir-akhir ini mengalami perkembangan yang sangat pesat, perhatian dunia usaha terhadap kegiatan bisnis internasional juga semakin meningkat, hal ini terlihat dari sistem berkembangan arus peredaran barang, jasa, modal, dan investasi lainnya, antarnegara.Untuk meningkatkan kegiatan perdagangan internsional, pemerintah pusat (raja) mempunyai kekuasaan yang bersifat absolut yang menghendaki agar negara kebangsaan atau nasional state menjadi kuat, baik dalam bidang politik, ekonomi, maupun militer.Dengan semakin kuatnya upaya pembebasan dari kaedah hukum feodal yang dianut di Eropa, maka dengan sendirinya akan menentang segala campur tangan pemerintah yang terlalu kuat di bidang ekonomi. Timbulnya kebebasan dalam melaksanakan perdagangan antarnegara, atau disebut dengan perdagangan internasioal termotivasi oleh paham atau teori yang dikemukakan oleh Adam Smith dalam bukunya “The Wealth of Nations” yang menyatakan bahwa kesejahteraan masyarakat suatu negara justeru akan semakain miningkat, jika perdagangan internasional dilakukan dalam pasar bebas dan atau pasar globalisasi (internensional).
Pengaruh Modal Sosial Petani Padi Sawah pada Integrated Participatory Development and Management of Irrigation Program (IPDMIP) terhadap Ketahanan Pangan di Kecamatan Lengayang Kabupaten Pesisir Selatan
Authors: Martadona Ilham , Angelia Leovita  , Yopa Dwi Mutia
Published: November 2024

Sektor pertanian memiliki peranan strategis dalam pembangunan perekonomian Indonesia.Mengingat pentingnya peran sektor pertanian sebagai penyedia pangan nasional, maka kontribusinya perlu ditingkatkan. Salah satu program pemerintah dalam hal meningkatkan ketahanan pangan adalah program Integrated Participatory Development and Management of Irrigation Program (IPDMIP). Salah satu modal yang digunakan dalam pelaksanaan program IPDMIP di Kecamatan Lengayang adalah modal sosial. Penelitian ini bertujuan untuk: (1) menganalisis faktor-faktor pembentuk modal sosial petani padi sawah program IPDMIP, dan (2) menganalisis pengaruh modal sosial terhadap ketahanan pangan. Contoh ditarik secara acak dari setiap kelompok tani secara proporsional, dengan jumlah total contoh sebanyak lima puluh. Data diolah secara kuantitatif menggunakan Structural Equation Modelling. Faktor-faktor pembentuk modal sosial petani padi sawah program IPDMIP adalah: kepercayaan (kejujuran dan sikap egaliter); norma (nilai-nilai bersama, dan aturan-aturan) dan jaringan (partisipasi, solidaritas dan kerja sama). Sedangkan pengaruh modal sosial terhadap ketahanan pangan adalah kepercayaan dan norma.
PERANCANGAN SISTEM INFORMASI AKUNTANSI BERBASIS FRAMEWORK CODEIGNITER PADA MASJID AN NUR KABUPATEN SANGGAU
Authors: Rahman Sastrawan  , Chornolius Hendreo  , Arief Rio Maulana
Published: November 2024

The mosque is a non-profit organization, whose income is based on voluntary donations from the community. The An Nur Mosque's financial management still uses conventional or manual methods. To improve accountable and transparent financial reporting, an accounting information system design was created that uses a website with the codeigniter framework method at the An Nur Mosque in Sanggau Regency, West Kalimantan. This research aims to develop an accounting information system that uses the codeigniter framework, with a focus on making it easier to prepare financial reports for the An Nur Mosque. The research method applied is descriptive qualitative with a waterfall method approach which includes various steps such as needs analysis, design, implementation and testing. The results of this research show that the design of an accounting information system can help non-profit organizations, especially the An Nur Mosque, in preparing more accurate and transparent financial reports.
PENGARUH GOOD CORPORATE GOVERNANCE, KONSERVATISME AKUNTANSI DAN UKURAN PERUSAHAAN TERHADAP MANAJEMEN LABA (Studi Empiris Pada Perusahaan Sektor Properti Yang Terdaftar Di Bursa Efek Indonesia Tahun 2018-2022)
Authors: Salma Maisaroh  , Kurnia Rina Ariani
Published: November 2024

This study aims to analyze the effect of Good Corporate Governance, accounting conservatism, and company size on earnings management (empirical study of property sector companies listed on the Indonesia Stock Exchange 2018-2022). This research method is quantitative. The object of this research is the annual report and audit report of Real Estate and property companies listed on the Indonesia Stock Exchange (IDX) for 2018-2022. The sampling method of this research is purposive sampling, with techniques based on judgment sampling considerations. The data used in this study are secondary. The data collection method is the documentation method. The analytical tool used in this research is multiple regression analysis with the help of the IBM Statistical Package for Sciences (SPSS) program version 26. The result of this study is that Good Corporate Governance has no significant effect on earnings management. Accounting conservatism hurts earnings management. Company size does not affect earnings management.
Genotypic Investigation of Antibiotic Resistance: Presence of BlaOXA-48 Gene in Clinical Isolates of Pseudomonas aeruginosa
Authors: Pourmohammadi Naser , Shapouri Reza , Nahaei Mohammadreza , Mohammadi Roknabadi Mojtaba
Published: November 2024

Background: Identifying antimicrobial resistance patterns and antibiotic resistance genes in clinical isolates of Pseudomonas aeruginosa is an important strategy for effectively combating infections. This study aimed to identify the antimicrobial resistance patterns and the presence of blaOXA-48 beta-lactamase gene in P. aeruginosa isolated from clinical samples. Methods: We collected 100 isolates of P. aeruginosa from different clinical samples, including urine, tracheal tube, blood, and burn wounds. The antimicrobial resistance patterns of the isolates were investigated using the disk diffusion method. Extended-spectrum beta-lactamase (ESBL) strains were analyzed phenotypically by the combined disk method. Furthermore, the presence of the blaOXA-48 gene in the isolates was assessed genotypically via molecular techniques. Results: The highest resistance of the isolates was detected for ceftazidime (89%) and ciprofloxacin (83%), whereas the highest sensitivity was detected for colistin (18%). The phenotypic method identified 68 (68%) ESBL-producing isolates among 100 isolates. In addition, blaOXA-48 gene was detected genotypically in 33 (48.5%) isolates among 68 ESBL-producer isolates. Moreover, a significant association was found between the presence of the blaOXA-48 gene and P. aeruginosa isolates’ resistance to cefepime, imipenem, and gentamicin (P<0.05). Conclusion: The study highlighted the significant prevalence of antimicrobial resistance in P. aeruginosa, particularly against ceftazidime and ciprofloxacin, although colistin remains largely effective. The association between the blaOXA-48 gene and resistance to key antibiotics such as cefepime, imipenem, and gentamicin underscores the need for continuous monitoring and strategic antimicrobial stewardship to mitigate the spread of resistant strains.
Molecular Surveillance of Artemisinin Combination Therapy Resistance Markers in Kelch13 Gene of Plasmodium falciparum Isolates Collected From Yobe State Nigeria
Authors: Zubair Abdulhamid Abubakar , Ajibade Gabriel Adegboyega , Haroun Ali Ahmed , Dikwa Karderam Bukar , Barde Sagir Adamu , Kopdorah Simdung Wuriba , Bulama Amina Yusuf , Abubakar Umar Faruk , Auwalu Muttaka , Bashir Muhammad Ribado
Published: November 2024

Background: Despite the discovery of artemisinin and artemisinin combination therapies (ACTs), resistance emerged due to single-nucleotide polymorphisms (SNPs) at the Kelch13 propeller domain of Plasmodium falciparum; the predominant parasite causing malaria. This research aimed at surveying the gene responsible for reduced parasite clearance of the first-line antimalarial ACT in Yobe State, Nigeria. Methods: This study analyzed the blood samples of 300 patients (18-50 years) from 3 different hospitals in Yobe State for malaria using a rapid diagnostic test (malarial strip test). The Giemsa microscopy protocol was performed on the samples that tested positive in order to increase specificity for high parasitemia. Positive samples from microscopy were confirmed by COXIII gene polymerase chain reaction amplification. The fragments of the P. falciparum kelch13 gene encompassing the propeller domains were amplified and sequenced to detect polymorphism. Results: The result of multiple sequence alignment of 16 successfully sequenced samples performed alongside the reference 3D7 strain revealed nine novel mutations that have not been reported elsewhere. Two were synonymous (S485S and A675A), and seven were non-synonymous (E461V, S485R, D648H, E668Q, S679L, H697Y, and W706M). The genetic diversity parameters obtained in this study indicated non-severe mutations with haplotype diversity [Hd=0.662, D (Tadjima)=-2.16692 and D* (Fu and Li) -3.08435]. Seven different haplotypes were discovered, and the result of the haplotype network demonstrated Hap_1 to be the predominant haplotype in the population. Conclusion: The absence of the WHO-validated markers may suggest that ACTs are still effective in Yobe.
Thymol Enhances Antibiotic Sensitivity and Inhibits Biofilm Formation in Urinary Tract Infection Isolates of Escherichia coli From Gilan Province, Iran
Authors: Dizani Fatemeh , Asadpour Leila
Published: November 2024

Background: The present study aimed to investigate the effect of thymol on growth inhibition, biofilm inhibition, and antibiotic sensitivity of Escherichia coli isolated from urinary tract infection in Gilan province, Iran. Methods: The disc diffusion and broth microdilution methods were used to investigate the antimicrobial effect of thymol on 30 urinary tract infection isolates of E. coli. Additionally, the time-kill assay was used to investigate the effectiveness of thymol at different time intervals over a period of 24 hours. The anti-biofilm effect of thymol was investigated using the microplate method. Moreover, the effect of thymol on fimH gene expression was investigated. To investigate the effect of thymol on the sensitivity of E. coli isolates to cefotaxime and ciprofloxacin, the checkerboard assay was used. Results: ThymolFF exhibits inhibitory effects on the growth of E. coli isolates and the diameter of the zone of growth inhibition caused by 5 mg of thymol in the studied isolates varied between 15 and 30 mm and minimum inhibitory concentration (MIC) of thymol against MDR E. coli isolates ranged from 1 to 4 mg/mL. Depending on the concentration and the exposure time, bacterial killing was promoted by thymol treatment. The use of thymol decreased the biofilm formation of the isolates by more than 50% compared to the control and also bacterial treatment with thymol led to down-regulation of the fimH gene. Furthermore, enhancing the antibacterial effect of cefotaxime and ciprofloxacin by thymol was demonstrated. Conclusion: The present study found that thymol, a terpenoid of plant origin, exhibited strong killing efficiency, inhibiting the biofilm formation, and enhanced antibiotic sensitivity of E. coli isolated from urinary tract infection.
Antibacterial Properties of Mint Nanoemulsion Against Uropathogenic Escherichia coli Carrying Beta-Lactamase Resistance Genes
Authors: Saker Alali Hala Maitham , Kariminik Ashraf , Ghane Maryam
Published: November 2024

Background: Uropathogenic Escherichia coli (UPEC) is a significant contributor to urinary tract infections (UTIs). The inappropriate prescription and utilization of antibiotics in treating UTIs have resulted in a rise in antibiotic resistance. The aim of this study was to investigate the antibacterial properties of mint nanoemulsion against beta-lactam-resistant strains of UPEC. Methods: Three hundred fifty urine samples were collected in sterile containers and cultured on eosin-methylene blue agar and blood agar media under sterile conditions. Microbial sensitivity testing was conducted using the standard disk diffusion method. Molecular analysis was performed to identify the blaTEM, blaSHV, and blaCTX genes in the samples. The mint nanoemulsion was produced using the low-energy method of spontaneous emulsion formation and characterized using scanning electron microscopy (SEM), dynamic light scattering (DLS), and Fourier-transform infrared spectroscopy (FTIR). The antibacterial activity of the mint nanoemulsion against multidrug-resistant (MDR) isolates underwent assessment. Results: One hundred UPEC strains were isolated and identified, showing differing levels of resistance and sensitivity to various antibiotics. Nitrofurantoin exhibited the highest resistance (22%), while amikacin had the lowest resistance (4%). The prevalence of the blaTEM, blaSHV, and blaCTX genes among the UPEC isolates was 93.33%, 100%, and 73.33%, respectively. The mint nanoemulsion demonstrated effective antibacterial activity against resistant isolates, with a minimum inhibitory concentration of 0.2 mg/µL and a minimum bactericidal concentration of 0.3 mg/µL. Conclusion: The resistance of UPEC against conventional antibiotics commonly used to treat UTIs was consistently high and demonstrated an increasing trend over time. This escalating situation could potentially become more severe in the future if the rational consumption of antibiotics is not carefully managed. Nanoemulsions synthesized using mint revealed promising stability and robust antimicrobial properties against UPEC isolates. Consequently, it is evident that these synthesized nanoemulsions represent a viable candidate as effective antimicrobial agents in combating antibiotic resistance in UTI treatment.
Anthrax Epidemıc Management in an Eastern Turkey Region
Authors: Akbulut Ayhan , Tanır Büşra , Tartar Ayşe Sağmak , Balin Şafak Özer , Şahin Mitat
Published: November 2024

Background: Anthrax is a zoonotic disease caused by Bacillus anthracis. It has been known for centuries and remains hyperendemic in certain parts of the world, with occasional epidemic outbreaks. This study aimed to investigate an anthrax outbreak affecting a family and their close contacts in the Akçakiraz town of Elazığ province in eastern Turkey. Methods: Twenty-two individuals who had contact with a sick animal in Akçakiraz were included in the study. Weekly anamnesis, physical examinations, and follow-ups were conducted over three weeks. Swab samples were collected from the wound sites of hospitalized patients for culture and Gram-staining. Blood and wound samples were sent for polymerase chain reaction (PCR) analysis to detect B. anthracis. A sample was taken from the liver tissue of the infected animal. Statistical analysis was performed using SPSS 25. Results: Of the 22 individuals, 9 (40.9%) were hospitalized and treated, while 13 (59.1%) were monitored on an outpatient basis. B. anthracis spores were identified in Gram-stained samples from the liver of diseased animal. PCR positivity for B. anthracis was detected in the wound samples of two patients (22.2%), although the PCR results from the blood samples of these patients were negative. No bacterial growth was observed in wound cultures, and gram-staining did not reveal any notable features. All patients were successfully treated. Contacts, family members, and residents were informed and educated about the disease, and necessary public health measures were implemented through coordination with the Provincial Hygiene Board. Conclusion: Increasing awareness of zoonotic diseases, especially anthrax, is essential. It is crucial to implement societal prevention measures, including controlling animal production, educating at-risk populations in endemic areas, vaccinating animals, preventing contact with sick or deceased animals, and preventing environmental contamination by decontaminating affected areas.
Relationship between Theory, Practice and Construction of Teaching Identity in Teacher Training for Basic Education: The Contribution of the Internship
Authors: Mariano Carvalheira Profa. Dra. Eliana
Published: November 2024

Este estudo objetiva investigar a contribuição do estágio na formação de professores para a educação básica sob a ótica de estagiárias do curso de pedagogia com destaque para a relação entre teoria e prática, e formação da identidade docente. O estudo utiliza uma abordagem qualitativa de caráter exploratório. A coleta de dados foi realizada por meio de um questionário. A análise desses dados indica que, embora o estágio tenha permitido às estudantes vivenciar na prática a teoria apresentada no curso, essa experiência não foi integradora, pois permaneceu a cisão entre a teoria e a prática. Além disso, o estágio não contribuiu para a formação de uma identidade docente reflexiva e crítica.
Characterization of Canine Patients with Heart Disease based on Age at the Pet`a Vet Veterinary Clinic in Guatemala City, Guatemala
Authors: De Leon Estephan Mendez , Leon Carlos de , Ayala Renzo Ricardo
Published: November 2024

In this study, the clinical records of canine patients seen at the Pet`a Vet veterinary clinic in Guatemala between 2018 and 2020 were analyzed with the aim of investigating heart disease in dogs in the region. From a total of 1215 records reviewed, 825 cases of heart disease were identified, with chronic mitral valve disease being the most frequent. A higher incidence was observed in males and in Schnauzer breed dogs. In addition, the majority of diagnosed patients were found to be 9 years of age or older. These results provide valuable information on the epidemiology of canine heart disease in Guatemala, which may be useful to improve its diagnosis and clinical management.
Concomitant Extraction of Wisdom Teeth with Bilateral Sagittal Split Osteotomy (BSSO): A Case Series
Authors: Ahmad, DDS Nadeen Haj , Quereshy, MD, DDS, FACS Faisal , Baur, DDS Dale
Published: November 2024

Aim: Aim:To investigate the incidence of postoperative complications (including pain, nerve damage, swelling and infection) associated with the concomit an textraction of wisdom teeth at the time of bilateral sagittal split osteotomy procedures.
Materials and Methods: A retrospective evaluation of eight patients who underwent concomitant removal of their lower wisdom teeth (either fully erupted, partially or fully bone impacted) at the time of their surgical procedure (Bilateral sagittal split osteotomy with/without LeFort 1 procedure/genioplasty). All patients presented to the Oral and Maxillofacial Surgery Department at Case Western Reserve University. Postoperative complications (including pain, nerve dysfunction, swelling and infection) were examined at regular follow-up appointments after their surgical procedure.
Results: A total of eight patients were examined for post operative complications. All patients confirmed the presence of mild pain/discomfort/swelling in the short-term postoperatively.
THE IMPLEMENTATION OF SONG ENGLISH TO IMPROVE STUDENTTS SPEAKING SKILL
Authors: Putri Firmansyah Zulaikha Salsabila , Nurul Awaliyah Neng Asti , Melinda Mira
Published: November 2024

This research aims to evaluate the implementation of using English songs as a learning tool in improving students' speaking skills. Speaking skills are an important aspect of foreign language learning, and innovative approaches such as the use of songs can be an interesting and effective way to achieve this goal.This research methodology involved students from various educational levels involved in learning sessions that include English songs. Data was colleted through a questionnaire which included students' level of confidence in speaking English, and their ability to understand pronunciation and accent. The research results show that the use of English songs has a positive effect on students' speaking skills. Most respondents reported that they felt more confident in speaking English after engaging in song learning. They also noted improved understanding of pronunciation and accent. However, this research also identified several challenges faced by students, such as difficulties in understanding songs lyrics and applying the vocabulary they learned from songs into everyday conversations.The result of this study provide additional support of the use English song as an effective learning tool in improving students' speaking skills. Therefore, this research implies the need to develop more efficient learning strategies and more appropriate teaching materials involving songs in the context of English learning in various educational institutions.Keyword: speaking skill, english song, song lyrics, song learning, vocabulary
INVESTIGATION OF THE EFEECT OF TBLT-BASED DIGITAL STORYBOOK ON STUDENTS’ WRITING COMPETENCY IN SMA N 1 BUSUNGBIU
Authors: Adi Darma I Nyoman Satya Surya
Published: November 2024

This study aims to investigate the significant effect of TBLT-based digital storybook among eleventh-grade students’ writing competency in SMA N 1 Busungbiu, Buleleng in academic year 2023/2024. This study was uses quasi-experimental research with Post-test only control group design. 63 eleventh-grade students are participated as sample in this study in which assigned into two group; experimental group which consisted of 34 students and control group which consisted of 29 students. Three instruments were used for data collection, namely lesson plan, writing test and assessment rubric. The two classes were given different treatment; TBLT-based digital storybook was treated in Experimental group and Teacher’ usual method was treated in Control group, by the end of the treatment writing test was given to students. The data was analyzed by using Independent sample T-test. The finding showed that there was a significant effect of TBLT-based digital storybook on students’ writing competency in SMA N 1 Busungbiu. Students that learn using TBLT-based digital storybook showed better result compared to students that learn using teacher’ usual method. It was proven by the Sig. (2-tailed) value of independent T-test was 0.001. Thus, the significance value of the tests was less than 0.05. Additionally, the effect size value measured using Cohen’s d was 0.917. This large effect means that the integration of TBLT method with technology in form of TBLT-based digital storybook can provide a good influence to students' Writing competency if compared to the teacher’s usual method.
MYSTICISM CONCEPT IN THE UNHOLY FILM
Authors: Lihawa Ayu Lestari , Wibowo Ary Iswanto
Published: November 2024

Mysticism is still an unknown field in terms of scientific research so to find out and explore the mysticism in the belief of religions expands to terms of evidence-based research. The concept of mysticism was analyzed in qualitative descriptive research with the emphasis on collective data extracted through numerous findings and evidence shown in the film to the connection between the statement of the concept as whole terms. Mysticism concept can be found in various religious beliefs of small communities with a sense of communicating through God, it gives a sense of enlightenment and connection towards the creator. Mysticism is a part of the different fields that have interested numerous experts in finding such claims that are based on history itself. In scientific fields, mysticism presents a form of union between the creator that experiences extrovertive (oneness) and introvertive (emptiness). The purpose of this research is to find basic understanding of the mysticism concept in broad view. When various activities in black magic and witchcraft may result in miracle phenomena research should be focused on the different cultures and religions far and wide, small or big communities. The main focus of the religion is Christianity and church authorities and the view to be explored in terms of their faith. The findings based on the main characterization are; Loyalty, Curiosity, Responsibility, and Religious Belief. Mysticism emphasizes all sorts of experiences beyond psychological and neurophysics as a whole. The main idea of this research is (1) to find the evidence based on the findings, (2) to determine the related characterization of Alice Pagett, (3) to find the relevance of the concept. The method used aside from qualitative is using theory of numerous experts related to the field of study from e-journals, e-books, and previous research results of interview depth-in and related characterization of the character. There are five pieces of evidence of concept in the film, three evidence of miracle phenomena, and four characterizations of Alice Pagett.
UTILIZING LINGUISTICS LANDSCAPE IN PROJECT-BASED LEARNING IN TEACHING WRITING IN JUNIOR HIGH SCHOOL
Authors: Devi Madhu Sri , Padmadewi Ni Nyoman , Artini Luh Putu
Published: November 2024

This study investigates the effectiveness of the Linguistic Landscape (LL) Technique through Project-Based Learning (PjBL) on seventh-grade students' writing skills at SMP PGRI 2 Denpasar. Industry 4.0's influence on education underscores the need for innovative strategies aligning with the 6C framework. Communication, a vital skill, is often challenging for students, prompting a focus on writing skills as a remedy. Project-Based Learning, particularly when incorporating Linguistic Landscape, emerges as a promising approach. This study employs a mixed-methods approach that utilizes a pre-experimental design involving tests, questionnaires, and interviews for data collection. As a result, the study demonstrates the positive impact of integrating Project-Based Learning (PjBL) and Linguistic Landscape (LL) on enhancing the writing skills of seventh-grade students at SMP PGRI 2 Denpasar. The findings emphasize the importance of innovative pedagogical approaches in preparing students for the demands of the evolving educational landscape
1874: Nasce la stereochimica
Authors: Noto Renato
Published: November 2024

Centocinquanta anni fa, due giovani chimici, van’t Hoff e Le Bel, con le loro pubblicazioni spiegavano quali caratteristiche strutturali dovevano soddisfare le molecole perché si manifestasse il fenomeno dell’attività ottica. In tal modo diedero il là a quella branca della chimica che conosciamo col nome di stereochimica. Le ipotesi avanzate dai due ricercatori erano differenti ma, come presentato in questa esposizione, l’una non escludeva l’altra anzi si può affermare che i due punti di vista si completavano a vicenda.
BIOSIMILAR MEDICINAL PRODUCTS – LEGISLATIVE DECISIONS AND MARKET ENTRY
Authors: Petrova Guenka , Boyadzhieva Vladimira , Stoilov Nikolay , Tachkov Konstantin
Published: November 2024

Biosimilar drugs, structurally identical and manufactured similarly to original biologic drugs, offer potential cost reductions in therapeutic practice, albeit with variations in adoption across European countries. This review synthesizes findings from literature examining legislative decisions and their effects on biosimilar market entry in Europe. Drawing from scientific articles and official documents, the review reveals that biologics constitute 36% of European drug expenditure, with the market valued at €78.6 billion in 2021 and growing annually at 10.5% over the past five years. Approximately 15% of new active substances centrally approved by the EMA in 2020 were biologics.
 The European biosimilars market is projected to reach €8.8 billion in 2021. Various measures are being implemented to boost biosimilar uptake, including pricing strategies, reimbursement policies, and substitution practices. Access, measured in terms of availability and time to entry, is still difficult in a number of countries, but legislative measures are helping biosimilars enter European markets more quickly.
An Extension of Generalized 𝑼|𝒉−Birecurrent Finsler Space
Authors: Al-Qashbari Adel M. , Abdallah Alaa A. , Nasr Kamal S.
Published: November 2024

This paper has focuses on a specific class of Finsler spaces known as generalized birecurrent Finsler space. By introducing a new geometric structure, we investigate the properties of these spaces and establish several theorems. Our results generalize previous work on birecurrent Finsler spaces and provide a deeper understanding of their geometry. In this paper, we introduced an extension of the generalized 𝑈−birecurrent Finsler spaces. i.e., we define a Finsler space 𝐹𝑛 which the curvature tensor 𝑈𝑗𝑘ℎ𝑖 satisfies the extension for generalized birecurrence property in sense of Cartan. Further, we get the relations among different curvature tensors in the main space.
Food Myths and Nutritional Fulfillment: The Social Construction of Women in Overcoming Stunting
Authors: Safitra Linda , Ibrahim Jabal Tarik , Ledyawati Ledyawati , Kristiono D.S Rachmad
Published: November 2024

Tackling stunting is a major challenge in many communities, including in Durian Depun Village. This research titled "Food Myths and Nutrition fulfillment: The Socio-Cultural Construction of Women in Overcoming Stunting" aims to examine how social construction and local myths influence women's decisions in providing nutritious food, as well as its impact on stunting prevention efforts. The research used a qualitative research method with a case study approach. The results showed that long-term malnutrition is one of the main causes of stunting in this area. Efforts to fulfill the nutrition of stunted children are carried out through counseling and providing nutritious food assistance such as eggs, SGM milk, and nuggets, which are managed by the kelurahan stunting task force with funds of around 25 million per year. However, there is a unique phenomenon in the field where some families are reluctant to accept assistance and mentoring, arguing that they can afford nutritious food and rejecting the notion that their children are stunted. Some mothers believe that stunting is hereditary and not the result of malnutrition. The study also found that while basic knowledge of good nutrition was present among women, daily practices were often inconsistent with this knowledge. The main factors affecting nutritional fulfillment were adjustments to family income, local knowledge about the virtues of rice, and myths about certain foods such as eggs and sea fish. The availability of nutritious food in local markets is also limited, which impacts on daily food choices. These limitations lead to the consumption of unbalanced foods, such as instant noodles and snacks favored by children, and neglect the need for protein and other essential nutrients. The accumulation of the above factors eventually constructs a minimalist diet in the family.
The role of Generative AI (ChatGPT) in optimizing the recruitment process in the organizations (the mediating role of level of position and organization size).
Authors: Abdelhay Dr Sameh
Published: November 2024

The primary objective was to understand the impact of Generative AI Tools on the recruitment process, on their effectiveness in addressing bias, enhancing efficiency, and ensuring accurate candidate evaluation and looking at the moderating role of familiarity and the mediating role of the size of the organization and level of employee. A cross-sectional survey approach, with 469 professionals participating in the survey and a questionnaire administered online, was used. Structural Equation Modeling (SEM) in Amos-SPSS was used in the analysis of the relationships between Generative AI Tools, User Familiarity with AI, and key outcomes in the recruitment process. The study reveals a significant reduction in bias during candidate screening, attributed to the algorithmic objectivity, data-driven decision-making, and consistency inherent in Generative AI Tools. Efficiency gains and heightened accuracy in shortlisting candidates were also observed. However, User Familiarity with AI emerged as a moderating factor in influencing the relationship between Generative AI Tools and efficiency improvement. As a recommendation, organizations are encouraged to invest in continuous training programs to harness the full potential of Generative AI Tools in optimizing efficiency and ensuring a fair and accurate recruitment process.
Hubungan antara Pengetahuan dengan Sikap Tentang Kanker Serviks pada Siswi SMA Lokon St. Nikolaus Tomohon
Authors: Ginting Joseph S. , Tendean Hermie M. M. , Wagey Freddy W.
Published: November 2024

Abstract: Lack of patient awareness can be caused by lack of education and campaign roles in providing education about cervical cancer to pre-teens and parents. Therefore, knowledge of cervical cancer plays an important role in the prevention of cervical cancer. This study aimed to determine the relationship between knowledge about cervical cancer and attitude towards cervical cancer prevention among female students at Lokon St. Nikolaus High School Tomohon. This was a comparative and analytical study with a cross-sectional design using a questionnaire. Samples were all female students at SMA Lokon St. Nikolaus Tomohon (high school) fulfilling the inclusion and exclusion criteria researchers. The results showed a total of 184 respondents were obtained with the majority of them were in class X (40.22%) and used information sources from the internet (50.00%). The majority of respondents had good knowledge (92.93%)) and supportive attitude (92.39%). In addition, eight students (4.35%) had received the HPV vaccine. The chi-square test showed a significant relationship between knowledge and attitudes about cervical cancer (p<0.05). In conclusion, there is a significant relationship between knowledge about cervical cancer and attitude towards cervical cancer prevention among female students at SMA Lokon St. Nikolaus Tomohon.
Keywords: cervical cancer; HPV vaccine; knowledge; attitude
  
Abstrak: Kurangnya kesadaran pasien terhadap kanker serviks dapat disebabkan oleh kurangnya peran pendidikan dan kampanye dalam memberikan edukasi mengenai kanker serviks pada pra-remaja hingga orang tua. Oleh karena itu, pengetahuan terhadap penyakit kanker serviks mempunyai peranan penting dalam pencegahan terhadap penyakit kanker serviks. Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan tentang kanker serviks dengan sikap terhadap pencegahan kanker serviks pada siswi di SMA Lokon St. Nikolaus Tomohon. Jenis penelitian ialah analitik komparatif dengan desain potong lintang menggunakan kuesioner. Sampel penelitian yaitu seluruh siswi SMA Lokon yang memenuhi kriteria inklusi dan eksklusi. Hasil penelitian mendapatkan total 184 responden dengan mayoritas responden berada dikelas X (40,22%) dan menggunakan sumber informasi dari internet (50,00%). Mayoritas responden memiliki pengetahuan yang baik (92,93%) dan sikap mendukung (92,39%). Terdapat delapan siswi (4,35%) yang telah menerima vaksin HPV. Hasil uji chi-square menunjukkan adanya hubungan bermakna antara pengetahuan dengan sikap tentang kanker serviks (p<0,05). Simpulan penelitian ini ialah terdapat hubungan bermakna antara pengetahuan tentang kanker serviks dengan sikap terhadap pencegahan kanker serviks pada siswi di SMA Lokon St. Nikolaus Tomohon.
Kata kunci: kanker serviks; vaksin HPV; pengetahuan; sikap