bluuebunny/crossref_metadata_2025 huggingface dataset:
The ecological and evolutionary significance of the crocodile-plover symbiosis – A review
Authors: Padmakumar Vidya , Shanthakumar Murugan
Published: May 2023

The present study investigates the epibiotic relationship between the Nile crocodlei (Crocodylus niloticus) and the Egyptian plover (Pluvianus aegyptius), also known as the crocodile bird. Epibiosis is a form of symbiosis where one organism resides on the surface of another. To understand this relationship, the present study examines the ecological and evolutionary context of it, as well as the behavioral and physiological mechanisms that facilitate it. Furthermore, the present study evaluates the implications and challenges for conservation of this relationship. To achieve these objectives, a literature review on this topic summarizes the main findings, which indicate that the crocodile offers a safe habitat for the plover to roost and nest, while the plover cleans the crocodile’s teeth and removes parasites. However, the present study also identifies the limitations and gaps in the current knowledge and proposes directions for future research. This study argues that this relationship between living organisms is a remarkable case of cooperation and confidence in nature, and that it deserves more interest from researchers and decision-makers.
La fe cristiana como horizonte de sentido ante la crisis migratoria
Authors: Guerrero Guerrero Vinicio Renato
Published: May 2023

A critical reflection is made on the current migratory crisis and examines the causes and consequences that have shocked the world today, sharpening its wounds.  The analysis focuses on the importance of Christian faith which, in front of the humanitarian crisis, the proliferation of xenophobic discourse, and the tendency to increasingly exclude migrants and refugees has taken an option for these vulnerable people. Inspired by the word of God and the Gospel of Christ, it not only defends migrants' dignity, but also works tirelessly  for its promotion and full humanization, recognizing in them the image of Christ and a sign of God's visit to the world at present. In fact, this study aims to show how faith is able to generate a horizon of sense, salvation, and hope in the middle of the current crisis and favor a liberating rereading, a reinterpretation of the sense of life for a group of migrants at Hogar de Cristo Foundation in Guayaquil.
Design of an Integrated Automation & Control System Using Petri Nets: Case Study
Authors: Núñez-Alvarez José Ricardo , Benítez-Pina Israel , Acosta-Montoya Guillermo , Pino-Escalona Alfredo , Villafuela-Loperena Luisa
Published: May 2023

El Sistema de Control y Automatización Integrado (IACS) basado en el control de eventos discretos mediante redes de Petri (PN) que abarca el diseño, análisis y validación de modelos de sistemas de bombeo industrial no se utilizan comúnmente. Nuestro caso de estudio es el diseño e implementación de un sistema de supervisión utilizando el software GHENeSys PN y EROS en la Estación de Bombeo "San Juan" en Santiago de Cuba, Cuba. Estas herramientas permiten describir los modelos de los estados del proceso automático local y el funcionamiento del Supervisor, para tener en cuenta, las funciones de Mantenimiento Preventivo y Tratamiento de Alarmas. El IACS parte de la simulación MatLab de los lazos de control principales y utiliza la red jerárquica extendida GHENeSys para modelar un sistema de automatización integrado estructurado modularmente que responde a las demandas funcionales sincronizadas. Esta metodología tiene las ventajas de una modularidad jerárquica completa desde el control local hasta la gestión de producción, varias herramientas modulares de verificación y validación y compatibilidad total con IEC61131. Esto reduce los errores de diseño y el tiempo de implementación con una mayor eficiencia de integración.
Performance simulation of water turbines by using 6-DoF UDF and sliding mesh methods
Authors: Chica Arrieta Edwin Lenin , Betancour Johan , Velásquez Laura , Rubio Clemente Ainhoa
Published: May 2023

In this work, a comparison between the six degrees of freedom (6-DoF) method and the sliding mesh approach in computational fluid dynamics simulations of an Archimedes screw turbine for hydrokinetic applications was performed using ANSYs Fluent software. The numerical curves obtained by representing the power coefficient () values versus the tip speed ratio ( or ) were compared based on the experimental data available in the literature. Therefore, by considering the  values as the comparison benchmark parameter between the numerical and experimental data, the error obtained when using the 6-DoF method and the sliding mesh approach was 13% and 40%, respectively. Both methods allowed the simulation of the rotor rotation, although the 6-DoF method was more accurate in the prediction of the turbine performance, higher computational resources were consumed in comparison with the sliding mesh method, which allows to obtain a computational solution in affordable times.
Heavy Metals Assessment in Sediments Beds of Habbaniyah Lake, Iraq
Authors: Ramal Majeed Mattar , Ghalib Huda Sulaiman
Published: May 2023

Heavy Metals (HMs) concentrations in a sediment sample from Habbaniyah Lake (HL), Iraq (Cr, Cd, Ni, Fe, Co, Zn, Pb, and Cu). 33 locations have been selected in the field of study from October 2020 to April 2021 to evaluate the contamination of HMs in sediments by using pollution load index (PLI), contamination factor (CF), Contamination degree (CD), and geo-accumulation index (I-geo). Atomic Absorption Spectrometer AAS was used to determine heavy metal concentrations (USA Phoenix-986). The following are the average concentrations: 2152.97 mg/kg for Fe, 47.35 mg/kg for Pb, 25.18 mg/kg for Cr, 18.00 mg/kg for Ni, 10.60 mg/kg for Co, 9.57 mg/kg for Zn, 4.53 mg/kg for Cu and 3.53 mg/kg for Cd during the research time. The average concentration of Pb, Ni, Fe, and Cd surpassed the USEPA recommendation. Cd is responsible for extremely high contamination; Pb is responsible for moderate pollution and severe contamination at some places based on the contamination factor (CF). According to contamination degree (CD), The Lake is classified as significant pollution degree and very pollution degree in some sites. Results indicated that HL is not contaminated with HMs according to geo-accumulation index and PLI for all sample locations during the study period. The lake is unpolluted by Fe, Cr, Co, Ni, Zn, and Cu according to contamination factor (CF), geo-accumulation index (I-geo), pollution load index (PLI), and Contamination degree (CD).
Movilidad social intergeneracional en México. El caso de las egresadas de educación preescolar durante la pandemia Covid 19
Authors: Mejía-Pérez Gustavo , González-Baños Jacobo , Alvarado-Pérez Francisco
Published: May 2023

El artículo analiza la movilidad social intergeneracional de mujeres fuera de la edad normativa (18 a 22 años) que estudiaron y trabajaron durante la licenciatura y que se dedican a la docencia, a partir de un seguimiento de egresadas de la licenciatura en Educación Preescolar (LEP) de la unidad 097 de la Universidad Pedagógica Nacional (UPN) en la Ciudad de México. Para la realización del estudio se aplicó un cuestionario en línea al que respondieron 128 egresadas. Los resultados muestran que los potenciales beneficios que la educación superior representa en términos de movilidad social se ven limitados por las condiciones de desventaja en las que viven y trabajan las egresadas de LEP, las cuales se acentúan por factores institucionales (como el bajo porcentaje de titulación de esta unidad) y contingencias (como la pandemia).
Factores que dificultan el proceso de adaptación de los estudiantes a la modalidad virtual. Estudio en tres instituciones de educación superior en Colombia
Authors: Arguelles Denise , Chica Francisco , Guzmán Maria-del-Socorro
Published: May 2023

La investigación pretende establecer los factores que, en los ámbitos de la autonomía, las actividades académicas, las emociones, la comunicación y la interacción, afectan la capacidad de adaptación de los estudiantes virtuales de educación superior en Colombia. El estudio, de enfoque cualitativo y tipo descriptivo, se realizó con 1 179 estudiantes de la Universidad Ean, el Politécnico Gran Colombiano y la Fundación Universitaria del Área Andina, de programas de pregrado en modalidad virtual, matriculados en primer semestre; cuarto y quinto; y séptimo, octavo y noveno semestres, considerando la diversidad en la duración de los mismos. La consulta se realizó en un mismo momento, por lo que los estudiantes en cada ciclo de formación son diferentes. Los resultados de la investigación demuestran que, para los cinco ámbitos enunciados anteriormente, el comportamiento de los datos es muy similar en los tres ciclos de consulta, lo que significa que la percepción de los estudiantes coincide en el nivel de impacto que se otorga a cada uno de los factores sobre los cuales se consultó.
Estrategias de aprendizaje autorregulado en estudiantes universitarios durante la contingencia COVID-19
Authors: Demuner-Flores María-del-Rosario , Ibarra-Cisneros Manuel-Alejandro , Nava-Rogel Rosa-María
Published: May 2023

El trabajo autorregulado cobró especial importancia ante la emergencia para encontrar soluciones a las problemáticas implicadas en el distanciamiento social y el cambio en las condiciones de la enseñanza. El objetivo de esta investigación fue analizar el uso de estrategias de aprendizaje y su relación con el rendimiento del aprendizaje en el contexto de educación en línea, derivado de la contingencia COVID-19. Se desarrolló un estudio descriptivo, transversal y de enfoque cuantitativo con una muestra de 611 estudiantes de una universidad mexicana. Los resultados revelaron que, aunque no disfrutaron la educación en línea orillada por la pandemia, su rendimiento del aprendizaje fue satisfactorio. El modelo de regresión jerárquica mostró alta influencia predictiva del uso de las estrategias de aprendizaje y baja influencia del contexto en el rendimiento del aprendizaje. Se desprende la necesidad de incrementar el desarrollo del aprendizaje autorregulado; para ello, los profesores deben fortalecer competencias pedagógicas y digitales.
Character Building in ECCD
Authors: Pimpalkar Dr. Nandkishor Tulshiram
Published: May 2023

Abstract: Education plays a very important role in each person’s life. Family & teachers are places of learning that's choked with true love and feeling. Good characters embodied within the family are terribly basic human characteristics. Children’s capability to operate as accountable voters should be nurtured timely. Family is that the smallest unit that has a very important role within the development of children's character, that lies in character education model given by the oldsters to their youngsters. Teachers develop the character of child through organizing completely different activities. Character education within a family has not been conceptualized in a very method that results in a spread of instructional practices in in keeping with the understanding of every parent.
Automatic Street Light On and Off Using LDR
Authors: Patil Anusuya , G Madhuri , K Pavithra
Published: May 2023

Abstract: Automatic Street Light Control System is a simple yet powerful concept, which uses transistor as a switch. By using this system manual works are 100% removed. It automatically switches ON lights when the sunlight goes below the visible region of our eyes. This is done by a sensor called Light Dependant Resistor (LDR) which senses the light actually like our eyes. It automatically switches OFF lights whenever the sunlight comes, visible to our eyes. By using this system energy consumption is also reduced because nowadays the manually operated street lights are not switched off even the sunlight comes and also switched on earlier before sunset. In this project, no need of manual operation like ON time and OFF time setting. This project clearly demonstrates the working of transistor in saturation region and cut-off region. The working of relay is also known.
Deep fake Detection Through Deep Learning
Authors: Doke Yash
Published: May 2023

Abstract: Deep fake is a rapidly growing concern in society, and it has become a significant challenge to detect such manipulated media. Deep fake detection involves identifying whether a media file is authentic or generated using deep learning algorithms. In this project, we propose a deep learning-based approach for detecting deep fakes in videos. We use the Deep fake Detection Challenge dataset, which consists of real and Deep fake videos, to train and evaluate our deep learning model. We employ a Convolutional Neural Network (CNN) architecture for our implementation, which has shown great potential in previous studies. We pre-process the dataset using several techniques such as resizing, normalization, and data augmentation to enhance the quality of the input data. Our proposed model achieves high detection accuracy of 97.5% on the Deep fake Detection Challenge dataset, demonstrating the effectiveness of the proposed approach for deep fake detection. Our approach has the potential to be used in real-world scenarios to detect deep fakes, helping to mitigate the risks posed by deep fakes to individuals and society. The proposed methodology can also be extended to detect in other types of media, such as images and audio, providing a comprehensive solution for deep fake detection.
The Effect of Entrepreneurial Leadership on Innovative Work Behavior and Job-related Psychological Well-being: Mediating Effect of Affective Commitment
Authors:   Korean Academy of Leadership, Wang Fei , Kim Jong Kwan
Published: May 2023

The recent dynamic business environment at home and abroad and rapid technological development increase the importance of employee innovative work behavior and job-related psychological well-being in securing competitive advantage and achieving organizational sustainability. Entrepreneurial leadership suggests that leaders possess the ability to motivate and direct subordinates to achieve organizational goals, including the recognition and exploitation of entrepreneurial opportunities.
This study is a study on the effect of entrepreneurial leadership on the innovative work behavior of employees, job-related psychological well-being, and the mediating effect of affective commitment. For the empirical analysis, 421 online questionnaires located in Beijing, China were used, and the hypothesis was verified using the structural equation model through Mplus 8.3. According to the analysis results, entrepreneurial leadership not only affects innovative work behavior and job-related psychological well-being, but also the mediating effect of affective commitment in the relationship between entrepreneurial leadership and innovative work behavior and job-related psychological well-being was verified.
The results of this study contribute to the study of entrepreneurial leadership. This study proposes some recommendations to increase employees' innovative work behavior and job-related psychological well-being. This suggests that organizational managers recognize the positive effects of entrepreneurial leadership and actively use entrepreneurial leadership.
The Study of the Relationship among Inclusive Leadership, Perceived Error Management Climate and Innovative Behavior
Authors:   Korean Academy of Leadership, Jin Jungge , Lim Sanghyuk , Kang Bogyung , Guo Yinping
Published: May 2023

Global competition, digital transformation brought about by the 4th industrial revolution, and the global pandemic brought about by the novel coronavirus have made companies adapt to changes and are constantly being asked to innovate. For the innovation of enterprises, the most direct and efficient way is to motivate employees to innovate behavior and innovation ability. Therefore, how to stimulate employees' innovation behavior has always been the focus of many scholars and many research results have been achieved. The purpose of this study is to better understand and analyze the innovative behavior of employees, and to study the structural relationship between inclusive leadership, error management climate, and innovative behavior.
Survey questionnaires were distributed to employees working at ten China companies, and responses from 343 employees were collected and used for data analysis. The main findings of this research are as follows: First, inclusive leadership had a significant positive(+) relationship with innovative behavior. Second, inclusive leadership had a significant positive (+) relationship with error management climate. Third,error management climate had a significant positive (+) relationship with innovative behavior. Fourth, error management climate played a mediating role in the relationship between inclusive leadership and innovative behavior.
Based on the results of this study, it provides suggestions on what kind of efforts companies should make in the future to lead effective innovative behaviors to organizational members, and these research results can be used as useful data.
“Servir a Deus e ao santo tribunal”: poderes e cooperação entre inquisição e igreja na América Portuguesa Colonial (casos de Pernambuco, Grão-Pará e Maranhão)
Authors: Pinheiro Adson Rodrigo Silva , Lacerda Lima João Antônio Fonseca
Published: May 2023

O artigo objetiva promover reflexões sobre as habilitações e os papéis desenvolvidos pelos comissários na atuação como agentes inquisitoriais. Além disso, busca-se entender como se deu a realização das trocas administrativas a partir dos bispados de Pernambuco, especialmente do Ceará, do Grão-Pará e do Maranhão, na América Portuguesa com a Inquisição em Lisboa, já que não houve esse tribunal fixo no Brasil. Esse processo de trocas feito pelas instituições, a episcopal e a inquisitorial, eram feitas mediante a cooperação entre os agentes de ambas, com o propósito comum de defender a ortodoxia católica no Ultramar. Dessa forma, o trabalho permite compreender o diálogo constante estabelecido entre elas para que conseguissem cumprir o papel doutrinário do catolicismo.
The Relationship Between Responses and Motivation Learning on Online Learning of 11th-Grade Students of Vocational High School Wiraswasta Cimahi in Islamic Religious Education Subject
Authors: Firdaus Nurul , Herdi Asep , Rahman Asep Andi , Husaeni Dwi Fitria Al
Published: May 2023

At this time, student motivation in learning Islamic Religious Education is still relatively low, especially during the COVID-19 pandemic. Various media were developed to support online learning. However, there are still many students who are indifferent during the learning process. This study aims to determine: (i) the reality of student responses to online learning during the covid-19 pandemic in class XI vocational high school Wiraswasta Cimahi, (ii) the reality of student learning motivation in Islamic religious education subjects in class XI vocational high schoolWiraswasta Cimahi, and (iii)the relationship between student responses to online learning during the COVID-19 pandemic and student motivation in Islamic religious education subjects in class XI vocational high schoolWiraswasta Cimahi. This study uses a quantitative approach with a descriptive method. In this study the sample was taken from 35 students of class XI vocational high schoolWiraswasta Cimahi. Data analysis of the two variables was carried out using statistical methods which were divided into two approaches, namely partial analysis and correlation analysis. Based on the results of the study, it was concluded: (i) the reality of student responses to online learning during the covid-19 pandemic was categorized as positive, at intervals of 3.40 - 4.19 (ii) the reality of their learning motivation in Islamic Religious Education subjects was categorized as good, at intervals 3.40 – 4.19, and (iii) the relationship between students' responses to online learning during the covid-19 pandemic with their learning motivation in Islamic Religious Education subjects is (a) a correlation coefficient of 0.58 including in the medium or medium category . (b) The hypothesis is accepted because t arithmetic is 4.09 greater than t table with (1.69), and (c) The degree of relationship between variable X and variable Y is 34%. Therefore, there is a relationship or influence between student responses to online learning during the COVID-19 pandemic and their learning motivation in Islamic Religious Education subjects
Pedagogia do quartel
Authors: Romualdo da Silva Joselita
Published: May 2023

Neste artigo buscou-se refletir teoricamente sobre os motivos pelos quais o estado do Paraná militarizou aproximadamente 10% da sua rede de ensino e qual é o projeto formativo para estudantesparanaenses nesse modelo educativo. Recorreu-se à análise de leis, projetos de lei, resoluções, atas das sessões da Câmara de Deputados e sites de órgãos públicos ou entidades civis organizadas, manuais de colégios cívico-militares e regimentos escolares, baseou-se, também, em estudos teóricos de Stephen Ball, Meg Maguire e Annette Braun (2016), Michael Apple (2003), Marina Lacerda (2019), Michel Foucault (2014), além de autores/as que pesquisam especificamente a militarização escolar no Brasil. Foi possível concluir que as escolas cívico-militares do Paraná integram uma política pública educacional neoconservadora, que surgiu como reação a movimentos sociais, objetivando a formação de corpos dóceis pela padronização e massificação do pensamento. Essa política é perigosa, pois castra o pensamento, fere direitos e subjuga crianças, adolescentes e jovens, contribuindo para que se tornem passivos/as e submissos/as.
Acute respiratory distress after metofluthrin insecticide ingestion in a 19-month-old girl
Authors: Choi Da Yeon , Kim Kyung Won , Yoon Seo Hee
Published: May 2023

Metofluthrin is a volatile pyrethroid insecticide. Despite being widely used as a safe household insecticide, it could cause severe systemic symptoms. A 19-month-old girl was taken to the emergency department after ingesting 1 mL of a mosquito repellent containing metofluthrin. After the arrival, the girl developed respiratory distress, which worsened progressively despite the administration of oxygen with nebulized salbutamol and budesonide. Additionally, she underwent application of high-flow nasal cannula, and administration of activated charcoal and systemic steroids. Her dyspnea gradually improved, and she was thus discharged on day 4 with oral prednisolone. All medications were discontinued 10 days after the discharge without any complication. Respiratory distress can develop after the ingestion of even a small amount of metofluthrin. Symptomatic and adjunctive steroid therapies can be effective therapeutic options.
EFEITOS DE SENTIDO EM TEXTOS SOBRE MATERNIDADE E FECHAMENTO DAS ESCOLAS DURANTE A PANDEMIA DA COVID-19
Authors: Pereira Aline Maria dos Santos , Batista Adriana Santos
Published: May 2023

Este artigo tem por objetivo analisar os efeitos de sentido produzidos sobre a maternidade, no contexto de fechamento das escolas devido à pandemia da Covid-19, em textos jornalísticos de grande circulação. A pesquisa tem por base os pressupostos teóricos da Análise do Discurso, especificamente, mobilizamos as noções de discurso, sentido, silenciamento, interdiscurso e memória discursiva. O corpus é constituído de trechos de cinco textos publicados nos seguintes jornais e portais de notícias: BBC News em São Paulo, Brasil de Fato, Carta Capital, El País e UOL em 2020. Os resultados apontam para (i) uma regularidade discursiva acerca de papeis historicamente discursivizados para o homem e para a mulher; (ii) uma instauração de paráfrases que sedimentam a naturalização da desigualdade de gênero e da sobrecarga materna e (iii) efeitos de sentido de uma relação intrínseca entre o funcionamento das escolas e a economia.
IKU E SEUS EGUNS NO MODERNISMO NEGRO AFROATLÂNTICO
Authors: Carrascosa Denise França
Published: May 2023

Este texto ensaia uma dança iansânica na espiral de um tempo que experimento chamar "portal de memória", metodologia origráfica que revela as forças AfroAncestrais do Orixá Iku e seus Eguns na Literatura Negra Brasileira e Afrodiaspórica. Com um cuidado inicial e iniciático, coreografo voltas em torno do Egun de Lima Barreto em seu centenário de morte.
"VOA VOA MARIA" E AS PERFORMANCES DO TEMPO ESPIRALAR
Authors: Vieira Thaís Aparecida Pellegrini
Published: May 2023

Neste breve percurso investigativo, a proposta que aqui desenho se curva às experiências rítmicas e estéticas das músicas e performances do samba de roda Voa Voa Maria, de Matarandiba. Por esse prisma, em primeira instância, tomarei algumas chaves analíticas, sendo que, dentre elas, destaco a concepção de tempo espiralar desenvolvida pela professora Leda Maria Martins (2021), numa perspectiva cósmico-filosófica da ancestralidade africana. Através do samba e seu território, a comunidade indica que suas enunciações poéticas conseguem fissurar a linearidade temporal hierarquizante do Chronos ocidentalizado, já que as vivências estéticas, através dessas vozes, corpos e tambores, estão em funcionamento de um tempo não linear, mas sim curvilíneo. Destarte, a tríade: corpo-tempo-movimento atua como prenuncio da potência literária presente no samba da localidade. No primeiro momento do texto, aporto em Itaparica, nas beiradas da maré matarandibense, e faço uma mostra desse cenário que inscreve o protagonismo e pertencimento local. Nessa perspectiva, as riquezas naturais gravitam como elementos vivos dessa poética contracosteira da ilha de Itaparica. Minha âncora será fincada em pensadoras e pensadores que permitam a percepção dos saberes imbricados na indagação proposta. Trago Krenak (2020), dialogando sobre a importância da Terra como ser ativo, bem como seus entrelaces com as humanidades, a fim de pensar a paisagem e o processo de ressignificação que é feito pela comunidade, capaz de subverter a ideia de subalternidade que permeia os cenários da contracosta. Martins (2020, 2021), Oyěwùmí, (2021), Sodré (1998, 2020), Zumthor (2000) os quais ajudarão a modular a relação corpo-tempo-movimento em face às possíveis simultaneidades que reativam e reinstauram esses corpos subalternizados como “tapeçaria de sentidos discursivos” (MARTINS, 2021, p.21).  Freitas (2016) nos permitirá fazer um exercício crítico literário operando o conceito de literatura-terreiro que, segundo o autor, “é aquela que, dentro da cosmogonia africana e/ou afro-brasileira explora a multimodalidade” (FREITAS, 2016, p.59). Com ele, será possível aferir acepções críticas nodais apontando o vigor do samba Voa Voa Maria como literatura.
Governmental Regulations on Volatile Organic Compounds in Paint
Authors: Hajra Rahim
Published: May 2023

Previous researchers have found that the use of VOCs (Volatile Organic Compounds), carcinogens, and PFAS (per- and polyfluoroalkyl substances) in paints have led to a wide range of health issues. This led to the primary goal within my research in which I examined the extent to which the quality level of paint is affected by chemical levels and pricing through the use of interviews with manufacturers from different paint companies, as well as the extent to which regulations from the EPA (Environmental Protection Agency) and OSHA (Occupational Safety and Health Administration) have limited the amounts of chemicals in paints. From this, I found that most companies are only restricted in levels of VOC and carcinogenic use, rather than PFAS since they are a necessary component of most paints, including within the linseed oil of oil paints, the pigments of watercolors and the pigments and solution of acrylic paints. Additionally, I found that these chemicals can affect one if they touch the surface of the skin or are inhaled, meaning that even dry paintings or painted walls could be toxic. The outcome emphasizes the necessity of wearing a mask while using these products, using warning signs on consumer products, as well as educating artists and those who are exposed to paints consistently to stay cautious.
Halal Food in Muslim Minority Tourism Destinations: Perspective of Toraja, Indonesia
Authors: Takdir Takdir , Hamida Ambas
Published: May 2023

Despite growing scholarly interest in halal tourism, there is still a gap on the study on the availability of halal food in areas where Muslims are not the dominant demographic. This has become an unresolved problem in the Indonesian tourism sector. Therefore, this current research examined the availability of halal food and the potential for developing halal cuisine in Tana Toraja,Indonesia. Data were collected through observation, interviews, and documentation from four informants consisting of the Tourism officers, the Indonesian Ulema Council, food sellers, and visitors. The data were analyzed through a process of data reduction, data presentation, and conclusion drawing. The findings revealed that Toraja, as a Muslim minority region, has limited access to halal food. Furthermore, the research identified a significant opportunity and potential for halal cuisine development through collaboration among stakeholders. Consequently, it is imperative that the government and tourism managers prioritize the availability of halal food in Tana Toraja.
Colchicine Binding Site Ligands: A Mechanistic Insight into their Influence and Dual Role
Authors: Dastidar Shubhra Ghosh , Basu Debadrita
Published: May 2023

The mechanism of disfavouring the growth of microtubule (MT) by a class
of compounds occupying a binding pocket of the constituent protein dimer
of α,β-tubulin, is not just about its tightness of association with
tubulin; instead it is more about the capacity of the ligand to induce
subtle yet global conformational changes and making the dimer
incompatible to the MT superstructure. Colchicine binding site is known
for harbouring various kinds of such small molecules. Although they
compete for the same binding pocket at the junction of the dimer; yet,
their phenotypic outcome differs: some of them are more potent than
others in arresting the cell cycle to antagonize mitosis, whereas some
others appear better as vascular disrupting agents (VDAs), with higher
impact on the cytoskeleton of the cells formed by the same dimer. How
the small molecules differing in shape, size and chemical structure
occupying the same binding pocket of the drug target can all act as
destabilizing ligands, yet distinctly diverge in their functions?
All-atom molecular dynamics simulation (~5.6 µs) has
identified that each ligand has its customized way of influencing the
complex network of intra- and inter-molecular interactions. The
preference for the two distinct conformational states is linked to the
preference for twisting or bending modes of internal motions of the
complex. The milder influence of a ligand makes it a VDA (TUB092) and
the stronger impact makes the classical ligand Colchicine (COL) an
anti-mitotic agent (AMA); whereas the other two ligands BAL27862 (2RR)
and Nocodazole (NZO) falls in the intermediate zone. Apart from
differentiating the molecular mechanisms of VDA and AMA this work
proceeds further to dig into the overall allosteric mechanisms involved
with ligand binding at the Colchicine Binding Site (CBS). The detailed
investigation on which, led to the detection of important hubs for
allostery and the revelation of key contacts, leading to a positive
allosteric effect on the tubulin dimer upon each ligand binding.
Monkeypox: A review of outbreaks and on current scenario
Authors: Kalita Jitu , Ahmed Iftikhar
Published: May 2023

Monkeypox (Mpox) is a re-emerging zoonotic disease caused by Monkeypox
virus. Several countries in the world have been reported Mpox outbreak
recently besides West and Central Africa where it is an endemic disease
which is a warning signal and it becomes a global public health concern.
The infection can be transmitted from one infected person or animal to
another. Fever, rash and lymphadenitis are the most common symptoms.
Smallpox vaccines can be used for prevention of Mpox along with general
measures. This review article covers the epidemiology, current outbreak
and preventive measures of Mpox.
Herbal remedies for hyperlipidemia modulate proteins associated with cancer and hyperlipidemia
Authors: Cheng Xiao , Sun Geng , Meng Li , Liu Yueli , Wen Jiangnan , Zhao Xiaoli , Cai Wenhui , Xin Huawei , liu yu , Hao Chunxiang
Published: May 2023

Many herbs and herbal formulae have been proven to offer safe and
effective treatment for hyperlipidemia. However, the molecular
mechanisms of their treatment have not been fully elucidated. Here, a
total of 103 herbal formulae, including 146 individual herbs used to
treat hyperlipidemia, were screened. Next, 40 common targets of core
herbs and hyperlipidemia were extracted, representing potential targets
of the herbal medicines for the treatment of hyperlipidemia. Further
analysis revealed that the seven proteins most relevant to
hyperlipidemia treatment were IL6, AKT1, IL1B, PTGS2, VEGFA, PPARG, and
NOS3. Surprisingly, KEGG pathway enrichment analysis suggested that the
herbs may treat hyperlipidemia by influencing the lipid and
atherosclerosis pathway and the pathway in cancer. Molecular docking
revealed significant affinity between bioactive compounds such as
physciondiglucoside and baicalin with proteins involved in cancer
pathways. Three active compounds, including
3-beta-hydroxymethyllenetanshiquinone, dan-shexinkum d, and
physciondiglucoside have good binding ability with AKT1, PTGS2, and
PPARG. The anti-hyperlipidemia activity of herbal medicines may be
mediated via regulating proteins with roles in cancer. This study
provides further evidence supporting the potential pharmacotherapeutic
candidates for the combined treatment of hyperlipidemia and cancer in
the future.
Computational Modelling of Prandtl-Nanofluid flow using Exponentially Vertical Surface in terms of Chemical Reaction
Authors: Biswas Rajib , falodun B.O. , Islam Nazmul , Ahmmed Sarder , Mishra Dr. Satyaranjan , Afikuzzaman Mohammad
Published: May 2023

Current study examined the magnetohydrodynamic (MHD) Prandtl nanofluid
of a thermal double-diffusive flow through an exponentially vertical
surface in association with heat generation, and thermophoresis effect.
The novelty of this study is due to the analysis of Prandtl nanofluid
model with Soret mechanism and chemically responding fluids. The fluid
flow phenomenon is characterized by nonlinear coupled differential
equations involving two or more independent variables. A suitable
numerical technique is used to handle the set of governing equations
along with a stability and convergence analysis. According to recent
study, the fluid velocity increases since all the parameters are set to
higher levels. For the various parametric values, isotherms and
streamlines have been explored. This suggested model is beneficial since
it can significantly advance the domains of thermal and industrial
engineering. For instance, thermal radiation is crucial in designing
sophisticated energy-transformed systems that operate at high
temperatures. On the other hand, the phenomenon of Soret is useful in
separating isotopes in chemical engineering. These studies have several
applications in the manufacturing and biomedical fields, petrochemical
industries, automobiles, medical sciences, and various production
processes in industries.
Genetic adaptations in the population history of Arabidopsis thaliana
Authors: Kishino Hirohisa , Nakamichi Reiichiro , Kitada Shuichi
Published: May 2023

The Arabidopsis thaliana population has been exposed to unexperienced
biotic and abiotic stresses as a result of range expansion or
environmental change. To obtain a global picture of the genetic
adaptations in the population history of A. thaliana, we constructed a
database of the phenotypic-adaptations (p-adaptations) and gene
expression-adaptations (e-adaptations). We analysed the dynamics of the
allele frequencies at the 23,880 QTLs of 174 traits and 8,618 eQTLs of
1,829 genes with respect to the total SNPs in the genomes, and
identified 650 p-adaptations and 3,925 e-adaptations (FDR=0.05). The
population underwent large scale p-adaptations and e-adaptations along
four lineages, the eastward migration to Central Asia and South Siberia,
Russia, the northward migration to Sweden, the migration to Azerbaijan,
and the migration of the German population to the United States.
Extremely cold winters and short summers prolonged seed dormancy, and
expanded the root system architecture. Low temperatures prolonged the
growing season and low light intensity required the increased
chloroplast activity. The subtropical and humid environment enhanced
phytohormone signaling pathways in response to the biotic and abiotic
stresses. Exposure to heavy metals selected for alleles underlying low
heavy metal uptake from soil, lower growth rate, lower resistance to
bacteria, and higher expression of photosynthetic genes were selected.
The database of p-adaptations and e-adaptations, which complements
studies focusing on specific aspects of adaptation, may be useful for
future studies to understand the biological adaptations of A. thaliana
throughout its population history.
Molecular PET/CT mapping of rhACE2 distribution and quantification in organs to aid in SARS-CoV-2 targeted therapy
Authors: Zhu Hua , Wang Zilei , Zhao Chuanke , Li Chuangui , Liu Song , Ding Jin , He Chengxue , Liu Jiayue , Dong Bin , Yang Zhi , Liu Qi , Liu Youping
Published: May 2023

Objectives The aim of this study was to assess the potential of
noninvasive and repeated monitoring of rhACE2 distribution and content
in organs using the ACE2-specific nuclide probe
Ga-HZ20. Methods We optimized the labeling
conditions of the probe and evaluated its safety. A mouse organ in
situ rhACE2 high-aggregation model was constructed for the first time,
and in vivo real-time PET imaging of rhACE2 was performed using
the ACE2-specific PET agent Ga-HZ20. The
distribution and uptake of the probe were analyzed, and the model was
validated. Results This radiotracer exhibited reliable
radiochemical properties in vitro and maintained a high affinity
for rhACE2 in vivo. In terms of probe uptake,
Ga-HZ20 showed a good target-to-nontarget ratio, and
the correlation between the uptake value of the probe and the dose of
rhACE2 was >90% in both models; the probe was rapidly
cleared from the circulatory system and excreted by the kidneys and
urinary system. No organs were damaged after the injection of high doses
of probe. Conclusions This technology for noninvasively and
repeatedly monitoring the content and distribution of rhACE2 in
vivo aids in clarifying the resident capacity of rhACE2 in organs and
in analyzing the preventive effect of rhACE2 against SARS-CoV-2 and the
effectiveness of therapies for COVID-19.
Variation in Severity of Symptoms Associated with Two Snow Mountain Virus Inocula
Authors: Liu Pengbo , Qu Hongyan , Rouphael Nadine , Mulligan Mark , Wang Yuke , Moe Christine
Published: May 2023

Background: Norovirus (NoV) is a leading cause of epidemic non-bacterial
acute gastroenteritis in young children and adults globally. Snow
Mountain Virus (SMV), the prototype of genogroup II and genotype II NoV,
has been used in three human challenge studies to examine the
infectivity, pathogenicity, and immune response to NoV. Methods: This is
a secondary data analysis. Clinical and laboratory data from two
previously completed SMV human challenge trials using two different
inocula (Inoculum 1 and Inoculum 2) were analyzed to compare
infectivity, illness (including modified Vesikari severity scores of
gastroenteritis in those subjects with clinical symptoms), viral
shedding, and serum IgG conversion. SMV Inoculum 2 is a
second-generation inoculum prepared from a stool sample collected from a
study subject who was infected with SMV Inoculum 1. Results: Of 15
subjects orally challenged with SMV Inoculum 1 between 2000 and 2002,
nine were infected, and seven presented with acute gastroenteritis. Of
33 subjects orally challenged with SMV Inoculum 2 between 2016 and 2018,
25 were infected, and nine presented with acute gastroenteritis. There
were no statistically significant differences in overall infection and
illness rates between subjects challenged with Inoculum 1 vs. Inoculum
2. However, subjects infected with Inoculum 1 experienced more severe
clinical symptoms of acute gastroenteritis and had higher severity
scores (6.00 vs. 2.94, P = 0.003) compared with those infected with
Inoculum 2. We also observed that infection with Inoculum 2 resulted in
longer viral shedding compared with Inoculum 1. This analysis also
indicated that secretor-positive subjects had more severe
gastroenteritis than secretor-negative subjects. Among ill subjects, no
association was observed between challenge dose and severity of acute
gastroenteritis. Conclusions: Understanding the differences between
these two SMV inocula is critical for NoV vaccine evaluation because
illness and viral shedding are two important outcomes in NoV challenge
studies to determine vaccine efficacy. Using a less pathogenic inoculum
for a vaccine trial will require more participants to meet the target
reduction in illness when evaluating the efficacy of candidate vaccines.
Application of global analysis to linseed oil autoxidation
Authors: Kalbach Andrew , Parent Alexander
Published: May 2023

While the autoxidation of linseed oil has been extensively studied, the
role of metal driers in catalyzing this process remains poorly
understood. Previous studies have demonstrated that Fourier Transform
Infrared spectroscopy (FT-IR) can be used to monitor the progress of
autoxidation during linseed oil drying. Typically, studies have focused
on a single absorption at 3010 cm-1 to determine the rate of
autoxidation. In this study, FT-IR spectra of linseed oil during
autoxidation were measured between 3800 and 700 cm-1 and fit to kinetic
models using global analysis, which provides more robust fitting than
prior methods. This study revealed that the drier catalyzed autoxidation
process can be best modeled as an A → B → C type reaction, with B
corresponding to a cis-trans conjugated intermediate previously
identified in model complex studies. These kinetic models further
revealed that for three Co driers the rate constants for the A → B and B
→ C reactions are identical within experimental error, suggesting both
reactions share a rate limiting step.
Existence and stability of solutions for a coupled Hadamard type sequence fractional differential system on glucose graphs
Authors: Su Youhui , Nan Junping , Hu Weimin
Published: May 2023

Chemical graph theory is an interdisciplinary mathematics and chemistry
discipline that obtains mathematical information about the structure of
target compounds and is an important research branch in theoretical
pharmacology and nanomedicine. This paper study a coupled Hadamard type
sequential fractional differential system on glucose graphs and
establishes the Ulam’s stability and existence of the system solutions.
Furthermore, we examine examples against different background graphs and
provide approximate graphs of the solutions. The novelty of this paper
is that the origin of each edge is not fixed in modeling the glucose
graphs, and one of the two vertices of the corresponding edge can be
arbitrarily chosen as the origin to build the system and give the
approximate graphs of the solutions using iterative methods and
numerical simulation.
Blessing and curse of BioClim variables: A comparison of different calculation schemes and datasets for species distribution modeling within the extended Mediterranean area
Authors: Merkenschlager Christian , Bangelesa Freddy , Paeth Heiko , Hertig Elke
Published: May 2023

Bioclimatic variables (BCVs) are the most widely used predictors within
the field of ecological niche modeling. However, recent studies indicate
that BCVs alone are not sufficient to describe these limits and more
(bio)climatological variables should be considered. Unfortunately, the
most popular database WorldClim offers only a limited selection of
predictors; thus, other gridded station-based observations or reanalysis
(GSOR) datasets should be taken into account. In the present study, we
investigate how well the BCVs are represented by different GSOR datasets
for the extended Mediterranean area within the period 1970-2020, how
deviations among the datasets differ regionally and how different
calculation schemes affect the representation of BCVs. We consider
different calculation schemes for quarters/months, the annual mean
temperature and the maximum temperature of the warmest month and show
the effects on the respective BCV. Differences resulting from different
calculation schemes are presented for ERA5-Land. Selected BCVs are
analyzed to show differences between WorldClim, ERA5-Land, E-OBS and
CRU. Our results show that (a) deviations between the two calculation
schemes for annual mean temperature (maximum temperature of the warmest
month) diminish (increase) when the temporal resolution is decreased;
(b) with respect to the definition of the respective month/quarter,
temporal shifts can have substantially different effects on the BCVs,
depending on region; (c) overall, all datasets represent the different
BCVs similarly, but with partly large differences in some subregions;
(d) the largest differences occur when specific month/quarters are
defined by the seasonal cycle of precipitation. In summary, (a) since
the definition of BCVs matches different calculation schemes, a
transparent communication of the BCVs calculation schemes is inevitable;
(b) the calculation, integration or elimination of BCVs has to be
examined carefully for each dataset, region, period or species; (c) the
GSOR-Data provide, except some subregions, a consistent representation
of BCVs within the extended Mediterranean region.
Analysis and Application of Damping Characteristics of PSS and Traditional Supplementary Damping Controller based on Path-Damping Torque Coefficient Method in Wind-Thermal Bundled Power Transmission System with Series Compensation
Authors: Ma Yanfeng , Wang Yijing , Gao Li , Zhao Shuqiang
Published: May 2023

Wind-thermal bundled power transmission system with series compensation
(WTBPTSSC) is widely used in the power system. Power system stabilizer
(PSS) and traditional supplementary damping controller (TSDC) are often
installed to mitigate low-frequency oscillation (LFO) and subsynchronous
oscillation (SSO) in the power system. In this paper, the damping
characteristics and interaction of the controllers are analyzed to guide
the coordinated control of different controllers. In light of this
issue, a small-signal state-space model of WTBPTSSC was built first.
Then, the path-damping torque coefficient method combined with the
small-signal state-space model is proposed. The damping characteristics
of PSS and TSDC were analyzed, at the same time, PSS and TSDC providing
damping in different frequency bands were pointed out. Finally, through
theoretical analysis and simulation verification, the conclusion is that
there are few interactions between PSS and TSDC, but due to their
damping characteristics, PSS should be configured in priority when the
controller parameters are configured, which can make both low-frequency
oscillations and subsynchronous oscillations well suppressed.