bluuebunny/crossref_metadata_2025 huggingface dataset:
Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase
Authors: Leahy Darren , Grant Cameron , Jackson Alex , Duff Alex , Tardiota Nicholas , Van Haeften Jessica , Chen Xingchen , Peake Jonathan M. , Kruppa Michael D. , Smith Eliot T. , Johnson David A. , Lott William B. , Harris Jonathan M.
Published: September 2021

Human neutrophil elastase (HNE) is a uniquely destructive serine protease with the ability to unleash a wave of proteolytic activity by destroying the inhibitors of other proteases. Although this phenomenon forms an important part of the innate immune response to invading pathogens, it is responsible for the collateral host tissue damage observed in chronic conditions such as chronic obstructive pulmonary disease (COPD), and in more acute disorders such as the lung injuries associated with COVID-19 infection. Previously, a combinatorially selected activity-based probe revealed an unexpected substrate preference for oxidised methionine, which suggests a link to oxidative pathogen clearance by neutrophils. Here we use oxidised model substrates and inhibitors to confirm this observation and to show that neutrophil elastase is specifically selective for the di-oxygenated methionine sulfone rather than the mono-oxygenated methionine sulfoxide. We also posit a critical role for ordered solvent in the mechanism of HNE discrimination between the two oxidised forms methionine residue. Preference for the sulfone form of oxidised methionine is especially significant. While both host and pathogens have the ability to reduce methionine sulfoxide back to methionine, a biological pathway to reduce methionine sulfone is not known. Taken together, these data suggest that the oxidative activity of neutrophils may create rapidly cleaved elastase “super substrates” that directly damage tissue, while initiating a cycle of neutrophil oxidation that increases elastase tissue damage and further neutrophil recruitment.
Structural Insight into La0.5Ca0.5Mn0.5Co0.5O3 Decomposition in the Methane Combustion Process
Authors: Nikolaeva Olga , Kapishnikov Aleksandr , Gerasimov Evgeny
Published: September 2021

Perovskite-like solid solution La0.5Ca0.5Mn0.5Co0.5O3 was tested during the total methane combustion reaction. During the reaction, there is a noticeable decrease in methane conversion, the rate of catalyst deactivation increasing with an increase in temperature. The in situ XRD and HRTEM methods show that the observed deactivation occurs as a result of the segregation of calcite and cobalt oxide particles on the perovskite surface. According to the TGA, the observed drop in catalytic activity is also associated with a large loss of oxygen from the perovskite structure.
Improving the Berry Quality and Antioxidant Potential of Flame Seedless Grapes by Foliar Application of Chitosan–Phenylalanine Nanocomposites (CS–Phe NCs)
Authors: Gohari Gholamreza , Zareei Elnaz , Kulak Muhittin , Labib Parisa , Mahmoudi Roghayeh , Panahirad Sima , Jafari Hessam , Mahdavinia Gholamreza , Juárez-Maldonado Antonio , Lorenzo José M.
Published: September 2021

The production and sustainability of grape berries with high quality and health-promoting properties is a major goal. In this regard, nano-engineered materials are being used for improving the quality and marketability of berries. In this study, we investigated the potential role of chitosan–phenylalanine nanocomposites (CS–Phe NCs) in improving the quality of Flame Seedless (Vitis vinifera L.) grape berries, such as titratable acidity (TA), pH, total soluble solids (TSS), ascorbic acid, total phenolics, total flavonoids, anthocyanin, 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical scavenging activity, and phenylalanine ammonia-lyase (PAL) activity. In this context, grape berries collected in two growing seasons (2018–2019) were screened. Regarding the experimental design, the treatments included chitosan at a 0.5% concentration (CS 0.5%), phenylalanine at 5 mM and 10 mM concentrations (Phe 5 mM and Phe 10 mM), and chitosan–phenylalanine nanocomposites (CS–Phe NCs) at 5 mM and 10 mM concentrations. The lowest TA was recorded in grape berries treated with CS–Phe NCs with a 10 mM concentration. However, treatments enhanced with TSS, which reached the highest value with 10 mM of CS–Phe NCs, were reflected as the highest ratio of TSS/TA with 10 mM of CS–Phe NC treatment. Nanocomposites (NCs) also increased pH values in both study years compared to the control. Similarly, the ascorbic acid and total phenolic content increased in response to NP treatment, reaching the highest value with 5 mM and 10 mM of CS–Phe NCs in 2018 and 2019, respectively. The highest flavonoid content was observed with 5 mM of CS–Phe NCs in both study years. In addition, the anthocyanin content increased with 5 and 10 mM of CS–Phe NCs. PAL activity was found to be the highest with 5 mM of CS–Phe NCs in both study years. In addition, in accordance with the increase in PAL activity, increased total phenolics and anthocyanin, and higher DPPH radical scavenging activity of the grapes were recorded with the treatments compared to the control. As deduced from the findings, the coating substantially influenced the metabolic pathway, and the subsequent alterations induced by the treatments were notably appreciated due to there being no adverse impacts perceived.
N-Doped Biochar as a New Metal-Free Activator of Peroxymonosulfate for Singlet Oxygen-Dominated Catalytic Degradation of Acid Orange 7
Authors: Han Ruirui , Fang Yingsen , Sun Ping , Xie Kai , Zhai Zhicai , Liu Hongxia , Liu Hui
Published: September 2021

In this paper, using rice straw as a raw material and urea as a nitrogen precursor, a composite catalyst (a nitrogen-doped rice straw biochar at the pyrolysis temperature of 800 °C, recorded as NRSBC800) was synthesized by one-step pyrolysis. NRSBC800 was then characterized using XPS, BET, TEM and other technologies, and its catalytic performance as an activator for permonosulfate (PMS) to degrade acid orange 7 (AO7) was studied. The results show that the introduction of N-doping significantly improved the catalytic performance of NRSBC800. The NRSBC800/PMS oxidation system could fully degrade AO7 within 30 min, with the reaction rate constant (2.1 × 10 −1 min−1) being 38 times that of RSBC800 (5.5 × 10−3 min−1). Moreover, NRSBC800 not only had better catalytic performance than traditional metal oxides (Co3O4 and Fe3O4) and carbon nanomaterial (CNT) but also received less impact from environmental water factors (such as anions and humic acids) during the catalytic degradation process. In addition, a quenching test and electron paramagnetic resonance (EPR) research both indicated that AO7 degradation relied mainly on non-free radical oxidation (primarily singlet oxygen (1O2)). A recycling experiment further demonstrated NRSBC800’s high stability after recycling three times.
Impact of Lifestyle Behaviors on Postprandial Hyperglycemia during Continuous Glucose Monitoring in Adult Males with Overweight/Obesity but without Diabetes
Authors: Kishimoto Ichiro , Ohashi Akio
Published: September 2021

Data regarding hyperglycemia-related factors were scarce in people without diabetes. Fifty males (age 50–65 years) with overweight/obesity but without diagnosis of diabetes were recruited. After excluding participants with the 2 h plasma glucose value during a 75 g oral glucose tolerance test ≥200 mg/dL, continuous glucose monitoring (CGM) was performed for 6 days. Subjects with ≥1800 CGM readings were included (n = 36). The CGM indices of hyperglycemia were significantly associated with disposition index and snacking frequency. In receiver-operating characteristic analysis for predicting the maximal CGM glucose ≥200 mg/dL, the area under curves of disposition index, snacking frequency, and minimal daily step counts during the study were 0.69, 0.63, and 0.68, whereas the cutoff values were 1.57, once daily, and 2499 steps, respectively. After adjustments, the lower disposition index (≤1.57), higher snacking frequency (≥1 per day), and lower minimal step (≤2499 steps per day) categories conferred 14.5, 14.5, and 6.6-fold increased probabilities for having the maximum level ≥ 200 mg/dL, respectively. In addition, the snacking habits were significantly associated with insulin resistance and compensatory hyperinsulinemia. In conclusion, in middle aged males with overweight/obesity but without diabetes, snacking and physical inactivity serve as the major drivers of postprandial hyperglycemia independently of β-cell function.
Willow Aboveground and Belowground Traits Can Predict Phytoremediation Services
Authors: Gervais-Bergeron Béatrice , Chagnon Pierre-Luc , Labrecque Michel
Published: September 2021

The increasing number of contaminated sites worldwide calls for sustainable remediation, such as phytoremediation, in which plants are used to decontaminate soils. We hypothesized that better anchoring phytoremediation in plant ecophysiology has the potential to drastically improve its predictability. In this study, we explored how the community composition, diversity and coppicing of willow plantations, influenced phytoremediation services in a four-year field trial. We also evaluated how community-level plant functional traits might be used as predictors of phytoremediation services, which would be a promising avenue for plant selection in phytoremediation. We found no consistent impact of neither willow diversity nor coppicing on phytoremediation services directly. These services were rather explained by willow traits related to resource economics and management strategy along the plant “fast–slow” continuum. We also found greater belowground investments to promote plant bioconcentration and soil decontamination. These traits–services correlations were consistent for several trace elements investigated, suggesting high generalizability among contaminants. Overall, our study provides evidence, even using a short taxonomic (and thus functional) plant gradient, that traits can be used as predictors for phytoremediation efficiency for a broad variety of contaminants. This suggests that a trait-based approach has great potential to develop predictive plant selection strategies in phytoremediation trials, through a better rooting of applied sciences in fundamental plant ecophysiology.
Inverse Molecular Design Techniques for Green Chemical Design in Integrated Biorefineries
Authors: Lee Jamie W. Y. , Ng Lik Yin , Andiappan Viknesh , Chemmangattuvalappil Nishanth G. , Ng Denny K. S.
Published: September 2021

Over the past decades, awareness of the increase in environmental impact due to industrial development and technological advancement has gradually increased. Green manufacturing is one of the key approaches that begin to address environmental issues. With the current global attention, methodologies to incorporate green manufacturing into the design of green products through the green process route are much needed. However, it is challenging for industries to achieve this, as there is no definite definition of green. This work presents a systematic approach that provides a clear and consistent green manufacturing definition with a measurement method in terms of both product and process. With the consistent green definitions, the developed approach designs a product that satisfies green property and other product performance properties. In addition, the developed approach synthesises the production process that fulfils green manufacturing definitions and financial considerations for the designed product. A case study on the design and production of green biofuel is solved to illustrate the efficacy of the approach. Green product design is obtained by identifying molecular building blocks that fulfil the targeted properties using an inverse molecular design technique. The goal is to design a chemical product that is environmentally friendly while fulfilling customer requirements. Moreover, a superstructural mathematical optimisation approach is used to determine optimal conversion pathways that have minimal environmental impact on the production of the identified green product. The utilisation of multi-objective optimisation allows the design of product and process to strike a good balance between operational and environmental performances.
Arab Christian Confederations and Muhammad’s Believers: On the Origins of Jihad
Authors: Demichelis Marco
Published: September 2021

The meaning and elaboration of Jihad (just-sacred war) hold an important place in Islamic history and thought. On the far side of its spiritual meanings, the term has been historically and previously associated with the Arab Believers’ conquest of the 7th–8th centuries CE. However, the main idea of this contribution is to develop the “sacralization of war” as a relevant facet that was previously elaborated by the Arab Christian (pro-Byzantine) clans of the north of the Arabian Peninsula and the Levant and secondarily by the Arab confederation of Muhammad’s believers. From the beginning of Muhammad’s hijra (622), the interconnection between the Medinan clans that supported the Prophet with those settled in the northwest of the Hijaz is particularly interesting in relation to a couple of aspects: their trade collaboration and the impact of the belligerent attitude of the pro-Byzantine Arab Christian forces in the framing of the early concept of a Jihad. This analysis aimed to clarify the possibility that the early “sacralization of war” in proto-Islamic narrative had a Christian Arab origin related to a previous refinement in the Christian milieu.
Multiphoton Laser Fabrication of Hybrid Photo-Activable Biomaterials
Authors: Bouzin Margaux , Zeynali Amirbahador , Marini Mario , Sironi Laura , Scodellaro Riccardo , D’Alfonso Laura , Collini Maddalena , Chirico Giuseppe
Published: September 2021

The possibility to shape stimulus-responsive optical polymers, especially hydrogels, by means of laser 3D printing and ablation is fostering a new concept of “smart” micro-devices that can be used for imaging, thermal stimulation, energy transducing and sensing. The composition of these polymeric blends is an essential parameter to tune their properties as actuators and/or sensing platforms and to determine the elasto-mechanical characteristics of the printed hydrogel. In light of the increasing demand for micro-devices for nanomedicine and personalized medicine, interest is growing in the combination of composite and hybrid photo-responsive materials and digital micro-/nano-manufacturing. Existing works have exploited multiphoton laser photo-polymerization to obtain fine 3D microstructures in hydrogels in an additive manufacturing approach or exploited laser ablation of preformed hydrogels to carve 3D cavities. Less often, the two approaches have been combined and active nanomaterials have been embedded in the microstructures. The aim of this review is to give a short overview of the most recent and prominent results in the field of multiphoton laser direct writing of biocompatible hydrogels that embed active nanomaterials not interfering with the writing process and endowing the biocompatible microstructures with physically or chemically activable features such as photothermal activity, chemical swelling and chemical sensing.
Enhanced Changeover Detection in Industry 4.0 Environments with Machine Learning
Authors: Miller Eddi , Borysenko Vladyslav , Heusinger Moritz , Niedner Niklas , Engelmann Bastian , Schmitt Jan
Published: September 2021

Changeover times are an important element when evaluating the Overall Equipment Effectiveness (OEE) of a production machine. The article presents a machine learning (ML) approach that is based on an external sensor setup to automatically detect changeovers in a shopfloor environment. The door statuses, coolant flow, power consumption, and operator indoor GPS data of a milling machine were used in the ML approach. As ML methods, Decision Trees, Support Vector Machines, (Balanced) Random Forest algorithms, and Neural Networks were chosen, and their performance was compared. The best results were achieved with the Random Forest ML model (97% F1 score, 99.72% AUC score). It was also carried out that model performance is optimal when only a binary classification of a changeover phase and a production phase is considered and less subphases of the changeover process are applied.
Evolutionary Multi-Objective One-Shot Filter Pruning for Designing Lightweight Convolutional Neural Network
Authors: Wu Tao , Shi Jiao , Zhou Deyun , Zheng Xiaolong , Li Na
Published: September 2021

Deep neural networks have achieved significant development and wide applications for their amazing performance. However, their complex structure, high computation and storage resource limit their applications in mobile or embedding devices such as sensor platforms. Neural network pruning is an efficient way to design a lightweight model from a well-trained complex deep neural network. In this paper, we propose an evolutionary multi-objective one-shot filter pruning method for designing a lightweight convolutional neural network. Firstly, unlike some famous iterative pruning methods, a one-shot pruning framework only needs to perform filter pruning and model fine-tuning once. Moreover, we built a constraint multi-objective filter pruning problem in which two objectives represent the filter pruning ratio and the accuracy of the pruned convolutional neural network, respectively. A non-dominated sorting-based evolutionary multi-objective algorithm was used to solve the filter pruning problem, and it provides a set of Pareto solutions which consists of a series of different trade-off pruned models. Finally, some models are uniformly selected from the set of Pareto solutions to be fine-tuned as the output of our method. The effectiveness of our method was demonstrated in experimental studies on four designed models, LeNet and AlexNet. Our method can prune over 85%, 82%, 75%, 65%, 91% and 68% filters with little accuracy loss on four designed models, LeNet and AlexNet, respectively.
Results of the project «Optimization of the process of obtaining the service OCT “ (project implementation period 20.06.2019–08.10.2019)
Authors: Rakitina Irina Aleksandrovna , Iskhakova Alfiya Gumyarovna , Zamytsky Evgeny Andreevich , Makolina Marina Vladimirovna , Goleeva Farida Sagitovna , Balandina Elena Vladimirovna , Zakharova Tatyana Anatolyevna
Published: September 2021

Optical Coherence Tomography (OCT) is a modern, highly accurate, non-invasive study of various eye structures. OCT is a non-contact method that allows a specialist to visualize eye tissue with a very high resolution (1–15 microns), the accuracy of which is comparable to microscopic examination. The theoretical foundations of the OCT method were developed in 1995 by the American ophthalmologist K. Pulafito, and already in 1996–1997 Carl Zeiss Meditec introduced the first device for optical coherence tomography into clinical practice. Today, OCT devices are used to diagnose various diseases of the fundus and anterior segment of the eye. Due to the maximum accuracy, the method of light scanning greatly simplifies the diagnosis of pathologies of the organs of vision, regardless of the cause of their occurrence and the stage of the course. In terms of information content, the technique is not inferior to histology, but the advantage of OCT is the absence of the risk of injury to the eye tissues [1, 2].
Features of professional activities of the medical statistic of dental polyclinic
Authors: Zotova Irina Anatolyevna , Mambetova Svetlana Fedorovna
Published: September 2021

Health statistics help the heads of medical organizations to manage promptly, and doctors to judge the quality and effectiveness of treatment and prevention work. Qualified analysis of statistical data, assessment of events and relevant conclusions allow making the right management decision, contribute to better organization of work, more accurate planning and forecasting. Statistics helps to monitor the activities of the institution, to manage it promptly, to judge the quality and effectiveness of treatment and prevention work, including dental work.
Specific features of the head nurse’s work X-ray department of multidiscipline hospital
Authors: Popova Elena Valentinovna , Shestukhina Marina Nikolaevna
Published: September 2021

Modern departments of radiological diagnostics of large multidisciplinary hospitals are complex organizational structures, including subdivisions of X-ray diagnostics of various directions, ultrasound diagnostics, computed and magnetic resonance imaging. Today, X-ray diagnostics is undergoing a new development. Using the centuries-old experience of traditional X-ray techniques and armed with new digital technologies, radiation diagnostics is still the leader in diagnostic medicine.
Features of use in practical health care of the device «Multi-layer mat with an adhesive surface according to TA 32.50.50-009-21109965-2019, WITH ACCESSORIES»
Authors: Kozlov Viktor Yurievich , Karaseva Larisa Arkadyevna
Published: September 2021

A safe hospital environment should fully provide the patient and healthcare professional with the comfort and safety conditions that effectively address vital health needs. To this end, medical devices are manufactured for the healthcare industry to ensure the safety of the hospital environment for patients and medical workers [2, 3].
B₁₂-deficiency anemia in the work of the nurse
Authors: Skvortsov Vsevolod Vladimirovich , Ponomareva Anastasia Romanovna
Published: September 2021

B₁₂-deficiency anemia (megaloblastic anemia, pernicious anemia, Addison-Birmer disease), characterized by progressive hyperchromic, macrocytic anemia, hypersegmentation of neutrophil nuclei, megaloblastic erythropoiesis and morphological abnormalities of other hematopoietic growths in the bone marrow; Unlike other anemias, B₁₂-deficiency anemia is often associated with the development of pathological psycho-neurological symptoms (funicular myelosis).This article deals with problems of etiology, pathogeny, clinical symptomatology, approaches to detection and treatment of B₁₂-deficiency anemia.
Forms of drug allergy and various variants of its manifestation
Authors: Armakov Sergey Petrovich
Published: September 2021

Lately, the problem of drug allergy is becoming more and more urgent, which is a consequence of the wide availability of drugs and the widespread use of counterfeit drugs. According to some authors, the incidence of drug allergy reaches 60%. This pathological reaction is the result of the patient's individual intolerance to one or another medication, and is not inherently its side effect. In some cases, the ingestion of a minimum dose of a drug into the body is sufficient for a severe reaction to develop. Theoretically, any drug can cause an allergy, but there is a group of certain medications, to the ingestion of which an allergic reaction develops most often - these include antibiotics of the penicillin series, sulfonamides, analgesics, some antihypertensive drugs, B vitamins. An allergic reaction can develop with lightning speed, or it can manifest itself within a day. The most common forms of drug allergy include urticaria, Quincke's edema, and itchy rash (toxidermia). The most formidable manifestations of drug allergy are anaphylactic shock and Lyell's syndrome, which manifests itself in the form of total damage to the skin and mucous membranes.
Non-COVID community-acquired pneumonia in the practice of a family doctor
Authors: Skvortsov Vsevolod Vladimirovich , Skvortsova Ekaterina Mikhailovna , Eremenko \Andrey Andreevich , Yasko Nataliya Vladimirovna
Published: September 2021

This article provides basic information about the etiology, classification and diagnosis of community-acquired pneumonia. The main approaches to the treatment of this disease are outlined. The modern approaches to the treatment of this disease at the outpatient stage are considered.
Differential diagnosis of chronic diarrhea in patients with HIV infection
Authors: Petrischeva Olga Alekseevna
Published: September 2021

Today, when the whole world is overwhelmed by the coronavirus pandemic, few people remember that it was AIDS that was called the plague of the twentieth century. The manifestations of the acquired immunodeficiency syndrome are the terminal stage of infection of the body with the human immunodeficiency virus, which belongs to retroviruses and leads to the development of secondary immunodeficiency. The first case of HIV infection in adults was described in 1981 in America. A young homosexual came to one of the hospitals in the city of San Francisco with a persistent fungal infection. Some time after the treatment, the young man developed pneumonia, from the complications of which he soon died. The human immunodeficiency virus got its name only in 1982, and the disease caused by it began to be called the acquired immunodeficiency syndrome. At present, there are more than 40 million infected people in the world, 2/3 of whom live in Africa; in total, since the beginning of the epidemic, almost 100 million people have been infected with HIV, and the number of victims has doubled the number of people who died in the First World War. Despite the fact that this infection is not airborne or transmitted by contact, the growth rate of this disease continues to shock. Thus, about 5 thousand people get infected with HIV every day in the world; annually about 1 million die from complications of this disease. It should be noted that only 71% of those infected are aware of their status, all the rest continue to serve as a potential source of the spread of this terrible infection.
August 9 — the day of the Great Martyr Panteleimon, the holy healer
Authors: Rybachok Oksana Aleksandrovna
Published: September 2021

On August 9, Orthodox Christian churches celebrate the day of remembrance of one of the most revered saints - the Great Martyr Panteleimon. Panteleimon the healer - under this name we know the saint who provides all kinds of support to doctors and contributes to the recovery of the sick. His veneration in the Russian Orthodox Church dates back to the twelfth century, when Prince Izyaslav placed the image of Panteleimon on his battle helmet. Born into the family of a noble pagan, the young man lost his mother early and was raised by his father, who decided to teach his son the art of healing. Having met the Christian Ermolai, who was in exile and guarded the secret of his religion, the young doctor was baptized. This happened after seeing the body of a dead boy bitten by a snake on the street of the city, whom Panteleimon was able to bring back to life by the power of prayer.
Tejsav oligomerrel lágyított, politejsav-alapú biopolimer habok előállítása
Authors: Litauszki Katalin , Kmetty Ákos
Published: September 2021

Munkánk során a politejsav biopolimer alapvetően rideg viselkedését módosítottuk oligomer tejsav alkalmazásával. Sikeresen állítottunk elő folyadékadagoló használatával 5, 10, 20 %-ban oligomer tejsavval lágyított politejsav-keverékeket ikercsigás extrudálás segítségével. A gyártott keverékeket exoterm kémiai habképzővel habosítottuk. Az ilyen módon képzett habok sűrűségét mértük, illetve a töretfelületeket elektronmikroszkóppal vizsgáltuk, hogy a cellaszerkezet homogenitását, valamint a cellapopuláció-sűrűséget értékelhessük. Mindezek alapján úgy véljük, hogy az oligomer tejsavval való lágyítás hatékonysága tagadhatatlan, viszont a 190 °C-os gyártási hőmérséklet nem ideális a habképzés szempontjából. A jövőben a gyártási hőmérséklet csökkentése és optimalizálása esetén a kedvezőbb sűrűségű biopolimer habok gyártása ígéretes továbblépést jelenthet.
REGULARITIES AND PRINCIPLES OF A TEACHER’S PROFESSIONAL AND CULTURAL DEVELOPMENT
Authors: Kucheriavyi A.
Published: September 2021

The review article reveals the external and internal determinants, features, patterns of development of pedagogical professionalism, taking into account the provisions of system-structural, holistic, synergetic, axiological, acmeological, culturological, and personal-activity methodological approaches. The axio-acmeological cultural sphere of the teacher's personality is characterized as a strategic determinant of his professional and cultural development. The essence of internal determinants of professional and cultural growth of a teacher is analyzed: professional self - creativity, pedagogical creativity, and types of his activity in the context of professional and cultural targets.The system of regularities of development of pedagogical professionalism is defined: it is naturally subordinated to the strategic purposes of national cultural formation, nation-building and sustainable development of society; professional and pedagogical culture determines the development of pedagogical professionalism, acts as its strategic goal and the leading factor in updating the "I" -concept of professional and cultural development; The effectiveness of a teacher's career progress naturally depends on his awareness of the needs for a new strategy for teaching and educating students; the appearance in the psyche of the teacher of a new growth – the axiosphere of the culture of pedagogical professionalism, which is the result of the axiosphere of professionalism of personality and professionalism of activity; professional creativity and pedagogical creativity stimulate the development of pedagogical professionalism; the orientation of culturally relevant activities of the teacher naturally has the highest potential for their mastery of the values of the cultural sphere of the teacher's personality.Considerable attention is paid to the characterization of the author's principles of the ascent of the teacher's personality from pedagogical professionalism to professional-pedagogical culture.
TWO IMAGES OF MAKARENKO'S MAIN OPPONENT: VARIABILITY OF VALENTINA DUCHEN'S LIFE PATH
Authors: Tkachenko A. , Zhdanova-Nedilko O.
Published: September 2021

The article is devoted to the coverage of the eventful life path of A. Makarenko’s main ideological opponent – an active revolutionary, a well-known figure in national education, author of numerous pedagogical publications Valentina Diushen.The nature of V. Diushen's social origin and education, details of her revolutionary and educational-managerial activity, publishing activity are revealed, little-known biographical information about her family members is presented: the first husband – Borys Diushen, the second husband – Volodymyr Aussem, son – Ihor Diushen. The chronology of all known controversial moments of professional dialogue of V. Diushen and A. Makarenko is presented in detail. For the first time in the Makarenko literature, documentary evidence of A. Makarenko's reports on V. Duchen's affiliation with the Trotskyi opposition is presented.The set of found materials presents Valentina Diushen as a large-scale personality of a highly professional, active, able-bodied, and principled figure in the history of national education. However, it is the ambiguity, the contradiction of this figure that determines its opposed assessments by contemporaries.The conflict between Makarenko and Diushen must be viewed in two planes, the objective and the subjective. On the one hand, the tension of their professional relations as representatives of innovative pedagogy is evidence of the struggle that always accompanies the assertion of any new doctrine. On the other hand, both of these figures were extremely bright, original figures and, at the same time, extremely ambitious personalities. At the same time, the ambition and irresistibility of V. Diushen towards the self-confident but non-partisan head of the provincial institution were dictated by its administrative status, membership in the political elite, and metropolitan education and social background.So far, it is difficult to explain whether Diushen's opposition in any way influenced her pedagogical views, but it should be noted that A. Makarenko in his criticism of her makes a special emphasis on this circumstance.
OUTSTANDING MASTERS OF UKRAINIAN FOLK ART: BIOGRAPHICAL NARRATIVES
Authors: Mokhirieva Yu.
Published: September 2021

The article considers the problems of creating a semantic component of the pedagogical narrative (based on biographical studies of prominent personalities of Ukrainian national art) as an effective method of professional-pedagogical education of teachers of fine arts. Among the most representative phenomena of Ukrainian culture are the works by Hanna Sobachko-Shostak, Kateryna Bilokur, Oleksandr and Nadiia Babenko, the Piliuhin family. As a result of the research, the individual features of our selected outstanding masters of Ukrainian folk art were clarified, the influence of the social environment and the family on the formation and creative development of outstanding Ukrainian folk artists was determined.The Department of Fine Arts of Poltava V. G. Korolenko National Pedagogical University has developed biographical narratives about outstanding masters of Ukrainian traditional folk art, which are used in teaching the following subjects: "History of Ukrainian Fine Arts", "History of Decorative and Applied Arts", "Basics of Decorative Composition". The study proved the effectiveness and feasibility of introducing biographical narratives in the training of future teachers of fine arts.
ART-THERAPEUTIC METHODS OF A MUSIC TEACHER’S WORK
Authors: Burnazova V. , Kostievych O.
Published: September 2021

The article examines the problem of improving the psychophysical health of primary school students. The development of their musicality through a combination of visual, auditory, tactile, and motor sensations in the process of making music is described. Improvement of speech, coordination of movements, and fine motor skills of hands, emotional and sensory sphere is analyzed. It is the integration of children with mental and physical disabilities into the general educational space that is one of the areas of humanization of the entire education system and meets the priorities of public policy.The role and features of the use of art-therapeutic methods in the work of a teacher of music/art to create a comfortable environment for the formation of a comprehensively developed personality of the applicant of primary education are analyzed. Primary school is of special importance. As a child's psychological stability, personality traits, and character are formed during this period of their development. The experience of a specialist-practitioner of general secondary educational institution №52 in Mariupol was used, who for many years successfully implements art-pedagogical methods and techniques in music/art lessons and extracurricular activities in primary school, which contribute to the development of the emotional sphere of students with special educational needs. Psychophysical conditions, the formation of stable interest, and love for music are presented. Removal of neuropsychiatric overload, restoration of positive emotional and energetic tone is revealed. The creation of such conditions will ensure high-quality mastering of art by junior schoolchildren with special educational needs, as well as contribute to their spiritual, moral, and psychophysical development, which is relevant in the modern world.
DEVELOPMENT OF COMPLETE CONTROLLED BREATHING IN THE PROFESSIONAL FORMATION OF THE FUTURE SINGER
Authors: Derda I.
Published: September 2021

The article summarizes the long artistic and pedagogical author’s experience. The features of the development of complete controlled breathing in the process of professional development of the singer are characterized. It is proved that complete singing controlled breathing develops only through appropriate training through the use of special exercises for the respiratory system. Original preparatory and rhythmic exercises for the development of breathing during singing have been developed and described in detail. It is convincingly proven that complete controlled breathing combines the advantages of different types of breathing - diaphragmatic, costal, and clavicular. With fully controlled breathing, not only the respiratory system as a whole is mobilized, but also the functioning of the digestive, cardiovascular and nervous systems of the singer's body is improved, which has a positive effect on the qualitative characteristics of the singing voice. The main conditions of breathing exercises are as follows: clean air; light clothing that provides freedom of the chest and neck; performing exercises before eating; inhale air through the nose; do not overload the lungs with excess air; breathe evenly and elastically; to stand simply, naturally, having taken back shoulders a little, but not to lift them; perform exercises with maximum endurance, attention and calm; avoid excessive muscle tension. In order to master the technique of fully controlled breathing, it is necessary to conduct more classes and train at home on the basis of an individual training schedule.
MODERN TEACHERS OF PRESCHOOL AND EARLY SCHOOL EDUCATION IN POLAND ABOUT THE METHODS OF READING (PEDAGOGICAL THEORY AND PRACTICE)
Authors: Janicka-Panek T.
Published: September 2021

The experimental article presents the results of a study of methods of teaching reading to primary school children in Poland. The author describes the methodology and results of an experimental study involving certified teachers with relevant professional experience working in rural and urban schools. Respondents had to 1) choose from a list of methods that they know; 2) refer teaching methods to the names of their creators and its corresponding description; 3) determine the reasons for choosing one or another method of teaching reading; 4) name the frequency of use of reading exercises and their types; 5) provide information about the sources from which the interviewed teachers receive knowledge of the methods of teaching reading.The author emphasizes that primary school teachers in vocational education study and have at their disposal many methods of teaching reading to primary school children (color and sound method, composition method, good start method, an alternative method, natural reading method, early reading method, reading instruction and writing using the phonetic letter-color method, etc.). However, most often only one of them is used - analytical-synthetic, and the others are used sporadically. It has been experimentally proven that teachers do not see a connection between the low reading competence of many younger students and the limited methodological tools they use. Research results indicate routine and stereotypical exercises to improve reading, which may also be the cause of low effectiveness of reading instruction. It is necessary to raise the issue of the determinants of the analyzed pedagogical situation and look for effective methods of teacher training.
PREPARING EDUCATORS FOR THE USE OF INNOVATIVE TECHNOLOGIES FOR THE DEVELOPMENT OF CREATIVE STORYTELLING OF PRESCHOOLERS
Authors: Kotelianets Ju.
Published: September 2021

Speech competence is one of the leading basic characteristics of personality formed in ontogenesis. Mastering coherent speech is a component of pre-school children’s speech competence, which provides successful preparation for school. Therefore, the task of coherent speech development occupies a central place in the overall system of work on speech development in a pre-school educational institution. Modernization of pre-school education in Ukraine requires the implementation of innovations in the practice of working with pre-school children. Future pre-school teachers of the XXI century should be able to use innovative pedagogical technologies that will help them find their place in the chosen profession. In the process of studying in a higher educational institution, future pre-school teachers should master innovative technologies for the development of creative storytelling of preschoolers. The speech of older preschoolers is more coherent in situations based on visibility. It is facilitated by a modified method of perception of the image depicted in the picture by different senses, as well as modeling technology. In the process of studying in a higher educational institution, students should master the sequence of work on the formation of skills to compose a creative story: It is advisable to teach future pre-school teachers to use during classes V. Propp’s cards and give them instructions and recommendations how to build a methodological correct sequence of work with them. Thanks to the usage of the proposed method, the child’s creative potential is developed and realized, acquiring real forms of expressiveness.
THE INNER GAME CONCEPT AS A METHOD OF MUSIC COACHING
Authors: Petreniuk D.
Published: September 2021

Maximizing musician’s potential and creating effective performing skills in the process of their musical education and during the further professional development, as well as overcoming their own fears, doubts and limiting beliefs, particularly during performing in public, are still actual tasks both for musicians and their teachers.One effective approach to developing musician's creative potential is coaching. Coaching is based on a dialogue between the coach and the student (coachee); the coach proposes a series of questions aimed on assisting the student in finding their own solution of the problem. It has been known for a long time that the inner state of a person significantly impacts effectiveness of their actions. The Inner Game concept proposed by Timothy Gallwey is a coaching methodology designed to overcome inner obstacles in reaching person’s goals. Those obstacles are of mental nature and include loss of concentration, nervousness and self-doubt. What distinguishes the Inner Game from other coaching methods is that it utilizes statements and tasks that often do not require the student’s verbal answer (moreover, such verbal answer often cannot be given at all), but rather stimulate them to pay attention to their senses and to experiment (for example, in finding optimal position during playing an instrument or choosing proper dynamics for a certain music piece).The first principle of the Inner Game points out the fact that the quality of person’s performance depends not only on their potential (talent, skills, knowledge, etc.), but also on the level of self-interference (mental digression, untimely self-criticism, lack of confidence, fear, etc.).Traditional approach to improving performance suggests working on increasing the potential; the idea of the Inner Game is to decrease self-interference in order to bring the quality of the performance as close to the potential as possible.To describe the inner dialogue taking place inside person’s mind, notions of Self 1 and Self 2 are used. Self 1 is the source of self-interference, it contains person’s ideas about how the thins should be, their judgements and associations.  Self 2 is our inner potential, it includes our natural talents, abilities and skills. The methods of the Inner Game are used to decrease self-interference (impact of the Self 1) and help the performer to enter the ideal state during performance, the state of relaxed concentration.
SOCIAL ASPECT OF MUSEUM-EDUCATIONAL INTERACTION
Authors: Filipchuk N. , Udych Z.
Published: September 2021

The review article describes the social aspect of museum-educational interaction. It turns out that a museum is a unique place where an essential social model of ‘lifelong learning’ can be successfully implemented. It has been found that since the modern understanding of education as a process throughout life is associated with a person’s continuous personal development; the introduction of this concept in the museum space of culture is an obvious and natural phenomenon. In the museum, through studying and learning experience, the adaptation of the individual to the social and natural environment occurs using knowledge of past and present human existence. It has been found that museum pedagogy, as well as the learning process itself, should be considered in the context of its purpose, to apply its inherent methods, tools, technologies to all age groups, differing in education, social status, motivational interests, and more. It is substantiated that the use of the potential of museum institutions is expedient in the conditions of inclusion.

The authors prove that it is necessary to start implementing inclusion in the museum with special training of employees, which provides for the formation of values, sustainable and positive motivation to interact with people with disabilities, inclusive competence to interact with people with different communicative, intellectual, physical, sensory opportunities and persons accompanying them (assistants, parents, sign language

interpreters, etc.). Such training can be provided by inclusive education support centers, inclusive resource centers, advanced training centers, specialists working in inclusive education, etc. Excursion as a form of guided museum visit in an inclusive museum corresponds to the principle of accessibility, which involves not only providing verbal information but also involving all other senses of the visitor: tactile in combination with auditory, providing the ability to feel the vibration of the object, texture, material, etc.
ANTONIO SALIERI PEDAGOGICAL SCHOOL
Authors: Tsebriy I.
Published: September 2021

The article deals with the pedagogical school of Antonio Salieri, which was formed in the last quarter of the eighteenth – first quarter of the nineteenth centuries. This school was an artistic phenomenon, given that A. Salieri taught not only one instrument, but a whole set of musical disciplines (composition, counterpoint, conducting, solo and choral singing, harpsichord, stringed instruments, etc.). A. Salieri's

School is also unique because of the highest professional level preparation of a whole plaid of talented and even brilliant musicians - Ludwig Beethoven, Franz Schubert, Johann Nepomuk Gummel Franz Xaver Süsmayr, Anselm Hüttenbrüsner, Ignaz Carlethal Moscheles. Cavalieri, Anna Milder-Hauntmann, Anna Kraus-Vranitsky, etc. Based on sources and scientific works, the author of the article argues that the contribution of A. Salieri to the music pedagogy of the eighteenth and nineteenth centuries is invaluable. Antonio Salieri's pedagogical legacy is a unique phenomenon – he taught composition, instrumentation, instrument, vocals, counterpoint, homophony, polyphony, and most importantly - musical thinking. Many ingenious composers have left a unique legacy, but not many of them can boast of such a large number of students who have shown themselves in all spheres of musical life in the European world. We will not be mistaken when we say that Antonio Salіeri was unique in this. It is unlikely that the pedagogical legacy of another great musician will include pedagogue and methodologist Johann Nepomuk Hummel, the genius composer of all ages L. Beethoven, one of the first romantics – F. Schubert, vocalists - "opera stars'' Catherine Valba-Kanz, Fortunate Franquette, Amalia Josef-Mozatta. And this list can go on and on because the total number is over sixty.