bluuebunny/crossref_metadata_2025 huggingface dataset:
Data Supplement from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity
Authors: Cao Yuan , Slaney Clare Y. , Bidwell Bradley N. , Parker Belinda S. , Johnstone Cameron N. , Rautela Jai , Eckhardt Bedrich L. , Anderson Robin L.
Published: April 2023

Supplementary Table 1. Genes altered by BMP4 in whole tumor samples.
Supplementary Figure S3 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: April 2023

Restoration of LIMD2 in siRNA knockdown cells gained the function and phenotype of parental cells.
Data Supplement from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity
Authors: Cao Yuan , Slaney Clare Y. , Bidwell Bradley N. , Parker Belinda S. , Johnstone Cameron N. , Rautela Jai , Eckhardt Bedrich L. , Anderson Robin L.
Published: April 2023

Supplementary Figure 2. More aggressive breast cancers express lower levels of BMP4.
Supplementary Figures 1 - 7, Table 1 from A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells
Authors: Stehn Justine R. , Haass Nikolas K. , Bonello Teresa , Desouza Melissa , Kottyan Gregg , Treutlein Herbert , Zeng Jun , Nascimento Paula R.B.B. , Sequeira Vanessa B. , Butler Tanya L. , Allanson Munif , Fath Thomas , Hill Timothy A. , McCluskey Adam , Schevzov Galina , Palmer Stephen J. , Hardeman Edna C. , Winlaw David , Reeve Vivienne E. , Dixon Ian , Weninger Wolfgang , Cripe Timothy P. , Gunning Peter W.
Published: April 2023

PDF file - 1137K, Supplementary Figure 1: Tropomyosin siRNA knockdown is isoform specific and does not result in any compensation. Supplementary Figure 2: TR100 nullifies the impact of Tm5NM1 on actin filament depolymerization kinetics. Supplementary Figure 3: Anti-Tropomyosin compound impact on the actin cytoskeleton assessed by the microfilament disruption assay. Supplementary Figure 4: TR100 targets the actin cytoskeleton and preferentially disrupts LMW-cytoskeletal tropomyosin containing filaments. Supplementary Figure 5: TR100 shows no overt impact on synaptic integrity of hippocampal neurons. Supplementary Figure 6: TR100 induces apoptosis in tumor cells via a mitochondrial pathway. Supplementary Figure 7: TR100 does not impact liver function in vivo.Supplementary Table 1: Summary of impact of TR100 on tumor cell viability.
Supplementary Figure Legends from Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively
Authors: Weber Thomas G. , Osl Franz , Renner Anja , Pöschinger Thomas , Galbán Stefanie , Rehemtulla Alnawaz , Scheuer Werner
Published: April 2023

PDF file - 68KB
Supplementary Figure 2 from Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively
Authors: Weber Thomas G. , Osl Franz , Renner Anja , Pöschinger Thomas , Galbán Stefanie , Rehemtulla Alnawaz , Scheuer Werner
Published: April 2023

PDF file - 414KB, Supplementary Figure 2 - Fluorescence imaging after i.v. application of anti-DR5-Cy5 shows no specific antibody accumulation in the right brain hemisphere.
Supplementary Figure 1 from Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively
Authors: Weber Thomas G. , Osl Franz , Renner Anja , Pöschinger Thomas , Galbán Stefanie , Rehemtulla Alnawaz , Scheuer Werner
Published: April 2023

PDF file - 75KB, Supplementary Figure 1 - Highly sensitive apoptosis imaging allows tumor detection and randomization at early time points.
Supplemental Figure 1 from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival
Authors: Solari Valeria , Borriello Lucia , Turcatel Gianluca , Shimada Hiroyuki , Sposto Richard , Fernandez G. Esteban , Asgharzadeh Shahab , Yates Edwin A. , Turnbull Jeremy E. , DeClerck Yves A.
Published: April 2023

Analysis of enzyme expression in other non -neuroblastoma cell lines.
Supplementary Methods, Figures 1 - 7, and Tables 1 - 2 from Molecular Rules Governing De Novo Methylation in Cancer
Authors: Nejman Deborah , Straussman Ravid , Steinfeld Israel , Ruvolo Michael , Roberts Douglas , Yakhini Zohar , Cedar Howard
Published: April 2023

PDF file - 10686KB, Supplementary Figure S1. Single molecule methylation analysis. Supplementary Figure S2. Methylation of CRC islands in normal tissues. Supplementary Figure S3. Hypermethylation in cancer Supplementary Figure S4. Coefficient of methylation Supplementary Figure S5. Relationship between histone modifications and DNA methylation in cancer Supplementary Figure S6. Tissue specific DNA methylation in cancer. Supplementary Figure S7. Methylation and expression. Supplementary Table S1. DNA samples analyzed by mDIP arrays Supplementary Table S2. Tumor samples analyzed.
Supplementary Tables 1 - 6 from p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages
Authors: Lowe Julie M. , Menendez Daniel , Bushel Pierre R. , Shatz Maria , Kirk Erin L. , Troester Melissa A. , Garantziotis Stavros , Fessler Michael B. , Resnick Michael A.
Published: April 2023

PDF file - 63K, Table S1. Responsiveness of pro-inflammatory gene expression to p53 activation. Table S2. GO analysis of commonly regulated genes. Table S3. Conserved transcription factor binding sites in the promoters of commonly regulated genes. Table S4. Number of the commonly regulated genes with associated p53REs, kB sites, or both. Table S5. Highly induced common genes. Table S6. p53 response elements identified with p53 Scan.
Supplementary Methods, Figure Legend from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: April 2023

PDF file - 149K
Supplementary Methods from p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages
Authors: Lowe Julie M. , Menendez Daniel , Bushel Pierre R. , Shatz Maria , Kirk Erin L. , Troester Melissa A. , Garantziotis Stavros , Fessler Michael B. , Resnick Michael A.
Published: April 2023

PDF file - 30K
Supplementary Figure 3 from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: April 2023

PDF file - 154K, FIGURE S3 related to FIGURE 4. Characterization of GBM-derived EVs.
Supplementary Materials and Methods, Figures 1 - 4, Table 1 from Tumor-Infiltrating Myeloid Cells Activate Dll4/Notch/TGF-β Signaling to Drive Malignant Progression
Authors: Ohnuki Hidetaka , Jiang Kan , Wang Dunrui , Salvucci Ombretta , Kwak Hyeongil , Sánchez-Martín David , Maric Dragan , Tosato Giovanna
Published: April 2023

PDF file - 1522KB, Supplementary Figure S1: shows the kinetics of EL4, LLC1 and B16F10 tumor growth in WT and Gfi1-KO mice. Supplemental Figure S2: analysis of EL4 and LLC1 tumor vascularization (A); distribution and typical profiles of CD11b+Ly6C+Ly6G- and CD11b+Ly6C+Ly6G+ in spleen and bone marrow of naive and tumor-bearing mice (B-F). Supplementary Figure S3: typical sorting profiles of LLC1 tumorinfiltrating cell populations (A); expression profiles of Notch ligands and receptors in tumor cells and tumor-infiltrating populations (B); cartoon representation of interacting Notch ligands and receptors. Supplementary Figure S4: kinetic analysis of tumor growth with or without DAPT. Supplementary Table 1: Extensive gene expression profiling by qPCR.
Supplementary Table 1 from CD133+ Cancer Stem-like Cells in Small Cell Lung Cancer Are Highly Tumorigenic and Chemoresistant but Sensitive to a Novel Neuropeptide Antagonist
Authors: Sarvi Sana , Mackinnon Alison C. , Avlonitis Nicolaos , Bradley Mark , Rintoul Robert C. , Rassl Doris M. , Wang Wei , Forbes Stuart J. , Gregory Christopher D. , Sethi Tariq
Published: April 2023

PDF file - 82KB, IC50 values in uM of H345 and H69 cells treated with substance-P analogues.
Supplementary Figure 3 from Phosphorylation at Ser-181 of Oncogenic KRAS Is Required for Tumor Growth
Authors: Barceló Carles , Paco Noelia , Morell Mireia , Alvarez-Moya Blanca , Bota-Rabassedas Neus , Jaumot Montserrat , Vilardell Felip , Capella Gabriel , Agell Neus
Published: April 2023

PDF file - 646K, Fig. S3. Histological pattern of mice grafts derived from NIH3T3 expressing phosphomutants.
Supplementary Figures 1 - 7 from CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy
Authors: Ma Yuting , Mattarollo Stephen R. , Adjemian Sandy , Yang Heng , Aymeric Laetitia , Hannani Dalil , Portela Catani João Paulo , Duret Helene , Teng Michele W.L. , Kepp Oliver , Wang Yidan , Sistigu Antonella , Schultze Joachim L. , Stoll Gautier , Galluzzi Lorenzo , Zitvogel Laurence , Smyth Mark J. , Kroemer Guido
Published: April 2023

PDF file - 544K, Influence of anthracycline-based chemotherapy on myeloid cells in distinct lymphoid organs (S1); Impact of chemotherapy on the expression of M1 and M2 macrophage-related genes by Ly6Chigh cells (S2); Anthracycline-based chemotherapy activates antigen-specific T cells within neoplastic lesions (S3); Anthracycline-based chemotherapy fails to affect the proliferation of antigen-specific T cells within tumor draining lymph nodes (S4); Anthracycline-based chemotherapy induces fluctuations in the circulating levels of various myeloid cell populations (S5); Chemotherapy regulates the expression of chemokine-encoding genes by tumor-infiltrating leukocytes (S6); Expression of Ccr2 on malignant cells and tumor-infiltrating CD11b+ cells (S7).
Supplementary Methods, Figures 1 - 2, Tables 1 - 3 from CXM: A New Tool for Mapping Breast Cancer Risk in the Tumor Microenvironment
Authors: Flister Michael J. , Endres Bradley T. , Rudemiller Nathan , Sarkis Allison B. , Santarriaga Stephanie , Roy Ishan , Lemke Angela , Geurts Aron M. , Moreno Carol , Ran Sophia , Tsaih Shirng-Wern , De Pons Jeffery , Carlson Daniel F. , Tan Wenfang , Fahrenkrug Scott C. , Lazarova Zelmira , Lazar Jozef , North Paula E. , LaViolette Peter S. , Dwinell Michael B. , Shull James D. , Jacob Howard J.
Published: April 2023

Expanded Materials and Methods, Supplemental Figures, and Supplemental Tables Figure S1. Flow cytometric analysis of peripheral blood from SS, SS.BN3, SSIL2Rγ, and SS.BN3IL2Rγ rats. Figure S2.SH2B3 specifically marks CD31+ blood vessels, but not LYVE1+ lymphatic vessels. Table S1. Peripheral blood analysis of SS, SS.BN3, SSIL2Rγ and SS.BN3IL2Rγ rats. Table S2. Genes located in the overlapping portions of the rat chromosome 3 cancer QTLs. Table S3. Variants that cosegregate between tumor resistant (BN and Cop) and tumor susceptible (ACI, F344, and SS) rat strains.
Supplementary Figure Legends from Netrin-1 Promotes Medulloblastoma Cell Invasiveness and Angiogenesis, and Demonstrates Elevated Expression in Tumor Tissue and Urine of Patients with Pediatric Medulloblastoma
Authors: Akino Tomoshige , Han Xuezhe , Nakayama Hironao , McNeish Brendan , Zurakowski David , Mammoto Akiko , Klagsbrun Michael , Smith Edward
Published: April 2023

PDF file - 55KB
Supplementary Figure 5 from Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase
Authors: Xie Maohua , Yen Yun , Owonikoko Taofeek K. , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Doetsch Paul W. , Deng Xingming
Published: April 2023

PDF file - 66K, The BH4 domain is essential for Bcl2 to cause the asymmetrical DNA replication.
Supplementary Methods from Novel Bispecific Antibodies Increase γδ T-Cell Cytotoxicity against Pancreatic Cancer Cells
Authors: Oberg Hans-Heinrich , Peipp Matthias , Kellner Christian , Sebens Susanne , Krause Sarah , Petrick Domantas , Adam-Klages Sabine , Röcken Christoph , Becker Thomas , Vogel Ilka , Weisner Dietrich , Freitag-Wolf Sandra , Gramatzki Martin , Kabelitz Dieter , Wesch Daniela
Published: April 2023

PDF file - 34K
Data Supplement from Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC
Authors: Tchaicha Jeremy H. , Akbay Esra A. , Altabef Abigail , Mikse Oliver R. , Kikuchi Eiki , Rhee Kevin , Liao Rachel G. , Bronson Roderick T. , Sholl Lynette M. , Meyerson Matthew , Hammerman Peter S. , Wong Kwok-Kin
Published: April 2023

Supplemental Figure 1. Details about genetically engineered mouse model, with gross tumor lesions present in lung followed about negative FGFR2 IHC (control) and before/after BGJ-398 treatment.
Supplementary Figure S4 from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Authors: Rosanò Laura , Cianfrocca Roberta , Tocci Piera , Spinella Francesca , Di Castro Valeriana , Caprara Valentina , Semprucci Elisa , Ferrandina Gabriella , Natali Pier Giorgio , Bagnato Anna
Published: April 2023

Supplementary Figure S4. Macitentan and silencing of ÃŽÂ²-arr1 promotes antiproliferative effects and sensitizes chemoresistant cells to drug-induced apoptosis.
Supplementary Figure 2 from Critical Tumor Suppressor Function Mediated by Epithelial Mig-6 in Endometrial Cancer
Authors: Kim Tae Hoon , Lee Dong-Kee , Cho Sung-Nam , Orvis Grant D. , Behringer Richard R. , Lydon John P. , Ku Bon Jeong , McCampbell Adrienne S. , Broaddus Russell R. , Jeong Jae-Wook
Published: April 2023

PDF file - 308K, Steroid hormone-dependent formation of endometrial cancer induced the uteri of Wnt7acre+ Mig-6f/f mice.
Supplementary Figure 10 from Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer
Authors: Nagalingam Arumugam , Kuppusamy Panjamurthy , Singh Shivendra V. , Sharma Dipali , Saxena Neeraj K.
Published: April 2023

PDF file - 103KB, Supplementary Figure 10 Withaferin A induces recruitment of CHOP, pElk1 and release of HDAC1 from DR5 promoter.
Table S2. Gene Ontology Categories of Genes with Altered Expression in OV3/H1.3(H) Cells. from Histone H1.3 Suppresses H19 Noncoding RNA Expression and Cell Growth of Ovarian Cancer Cells
Authors: Medrzycki Magdalena , Zhang Yunzhe , Zhang Weijia , Cao Kaixiang , Pan Chenyi , Lailler Nathalie , McDonald John F. , Bouhassira Eric E. , Fan Yuhong
Published: April 2023

Table S2. Gene Ontology Categories of Genes with Altered Expression in OV3/H1.3(H) Cells. Gene Ontology Categories of Genes with Altered Expression in OV3/H1.3(H) Cells.
Supplementary Figures S1-S9 from Astrocyte Elevated Gene-1 Interacts with Akt Isoform 2 to Control Glioma Growth, Survival, and Pathogenesis
Authors: Hu Bin , Emdad Luni , Bacolod Manny D. , Kegelman Timothy P. , Shen Xue-Ning , Alzubi Mohammad A. , Das Swadesh K. , Sarkar Devanand , Fisher Paul B.
Published: April 2023

Supplementary Figures S1-S9. Co-Immunoprecipitation analysis of endogenous AEG-1 following Akt3 OE in glioma cell lysates. (S1); TCGA data analysis: Kaplan-Meir survival of GBM patients (n = 380) from TCGA datasets (S2); Analysis of glioma TMA Immunohistochemical staining scores (S3); OE of PH domains of Akt1 and Akt2 and Akt isoform specific knockdown with RNAi (S4); Cell proliferation assays. U87 cells transfected with AEG- 1, Akt1-PH and Akt2-PH in different combinations as indicated in the figure (S5). AEG-1 enhances the half-life of phospho-Akt S473 (S6); U87 parental cells and cells stably expressing AEG-1 transfected with/without Akt2-PH. Cells were treated with 20 μM CAPE (Caffeic Acid Phenethylester) and collected for immunoblotting (S7); Protein sequence alignment of human Akt isoforms (S8); Details of TCGA analysis (S table 1); Details of brain tumor TMA analysis (S table 2); AEG-1 does not regulate p-Akt1-S473 (S9).
Supplementary Table S1 from VEGF-Targeted Therapy Stably Modulates the Glycolytic Phenotype of Tumor Cells
Authors: Curtarello Matteo , Zulato Elisabetta , Nardo Giorgia , Valtorta Silvia , Guzzo Giulia , Rossi Elisabetta , Esposito Giovanni , Msaki Aichi , Pastò Anna , Rasola Andrea , Persano Luca , Ciccarese Francesco , Bertorelle Roberta , Todde Sergio , Plebani Mario , Schroer Henrike , Walenta Stefan , Mueller-Klieser Wolfgang , Amadori Alberto , Moresco Rosa Maria , Indraccolo Stefano
Published: April 2023

Supplementary Table S1. Primer Sequences.
Supplementary Video 1 from VEGF Regulates Region-Specific Localization of Perivascular Bone Marrow–Derived Cells in Glioblastoma
Authors: Burrell Kelly , Singh Sanjay , Jalali Shahrzad , Hill Richard P. , Zadeh Gelareh
Published: April 2023

MOV file - 7232KB, Time Lapse images capturing a 150msec time window demonstrates the ability of the imaging to track dynamically the movement of BMDCs and reconstituted blood through the vessels, (Green: BMDCs).
Supplementary Tables 1 - 4 from MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors
Authors: Luraghi Paolo , Reato Gigliola , Cipriano Elia , Sassi Francesco , Orzan Francesca , Bigatto Viola , De Bacco Francesca , Menietti Elena , Han May , Rideout William M. , Perera Timothy , Bertotti Andrea , Trusolino Livio , Comoglio Paolo M. , Boccaccio Carla
Published: April 2023

PDF file - 733K, Supplementary Table S1. Gene alterations in xenospheres. Supplementary Table S2. Cetuximab response in Raswt xenopatients and spheropatients. Supplementary Table S3. Tumor volumes and regression of M049-HGF spheropatients. Supplementary Table S4. List of primers used for gDNA sequencing and qPCR.
Supplementary Figure 3 from VEGF Regulates Region-Specific Localization of Perivascular Bone Marrow–Derived Cells in Glioblastoma
Authors: Burrell Kelly , Singh Sanjay , Jalali Shahrzad , Hill Richard P. , Zadeh Gelareh
Published: April 2023

PDF file - 796KB, IF images of ex vivo tissue demonstrates a regain of BMDCs in RTx treated tissue (Ai; GFP+ BMDC Green, CD31+ Red). The addition of AMG386 to inhibit ANg2 in un-irradiated tissue results in a slight loss in recruited BMDC to central vessels (Aii) whilst its addition following RTx significantly reduces BMDC recruitment (Aiii; GFP+ BMDC Green, Tumor Red, CD31+ Blue), similarly this pattern was seen following AMG386 administration following VEGFtrap (Aiv; Nuclei Cyan, Tumor Green, RFP+BMDC Red, CD31+ Blue). Quantification of the images demonstrates the significant increase in BMDC recruitment seen in central vessels following RTx (**p=0.001) or VEGFTrap (**p=0.0043) is significantly reduced when AMG386 was administered immediately after RTx (**p=0.0012) and VEGFTrap.
Supplementary Methods from MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors
Authors: Luraghi Paolo , Reato Gigliola , Cipriano Elia , Sassi Francesco , Orzan Francesca , Bigatto Viola , De Bacco Francesca , Menietti Elena , Han May , Rideout William M. , Perera Timothy , Bertotti Andrea , Trusolino Livio , Comoglio Paolo M. , Boccaccio Carla
Published: April 2023

PDF file - 121K
Supplementary Figure 2 from Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392
Authors: De Bellis Floriana , Carafa Vincenzo , Conte Mariarosaria , Rotili Dante , Petraglia Francesca , Matarese Filomena , Françoijs Kees-Jan , Ablain Julien , Valente Sergio , Castellano Rèmy , Goubard Armelle , Collette Yves , Mandoli Amit , Martens Joost H.A. , de Thé Hugues , Nebbioso Angela , Mai Antonello , Stunnenberg Hendrik G. , Altucci Lucia
Published: April 2023

PDF file - 147KB, Differences in gene expression between ATRA and MC2392.
Supplementary materials and methods from PDGFRα and β Play Critical Roles in Mediating Foxq1-Driven Breast Cancer Stemness and Chemoresistance
Authors: Meng Fanyan , Speyer Cecilia L. , Zhang Bin , Zhao Yongzhong , Chen Wei , Gorski David H. , Miller Fred R. , Wu Guojun
Published: April 2023

Supplementary materials and methods
Supplementary Figures 1-8 from PDGFRα and β Play Critical Roles in Mediating Foxq1-Driven Breast Cancer Stemness and Chemoresistance
Authors: Meng Fanyan , Speyer Cecilia L. , Zhang Bin , Zhao Yongzhong , Chen Wei , Gorski David H. , Miller Fred R. , Wu Guojun
Published: April 2023

Supplementary Figures 1-8. Supplementary Figure 1: EMT promoting transcription factors induce stemness characteristics in mammary epithelial cells. Supplementary Figure 2: The role of Foxq1 in drug resistance, mammosphere formation and tumor initiation. Supplementary Figure 3: Twist1 and Zeb2 regulate PDGFRs. Supplementary Figure 4: Correlation and survival analysis of Foxq1 and Twist1 with PDGFRα and PDGFRβ in tumor samples. Supplementary Figure 5: Effect of PDGFRα and PDGFRβ on cell migration, invasion and stem cell characteristics. Supplementary Figure 6: The effect of imatinib treatment on PDGFRs phosphorylation, mammosphere formation and EMT. Supplementary Figure 7: The Effect of PDGFRs and the treatment of imatinib on chemoresistance. Supplementary Figure 8: Immunohistochemistry (IHC) assays using tumor samples and our working model.
Supplementary Figure 4 from TGF-β Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment
Authors: Yeung Tsz-Lun , Leung Cecilia S. , Wong Kwong-Kwok , Samimi Goli , Thompson Melissa S. , Liu Jinsong , Zaid Tarrik M. , Ghosh Sue , Birrer Michael J. , Mok Samuel C.
Published: April 2023

PDF file, 2794K, The proposed model of TGF-B-modulated cross-talk between ovarian cancer cells and CAFs in the ovarian tumor microenvironment.
Supplemental data from Cytokine-like Molecule CCDC134 Contributes to CD8+ T-cell Effector Functions in Cancer Immunotherapy
Authors: Huang Jing , Xiao Lin , Gong Xiaoting , Shao Wenwei , Yin Yanhui , Liao Qinyuan , Meng Yang , Zhang Yingmei , Ma Dalong , Qiu Xiaoyan
Published: April 2023

Supplemental materials and methods and legends for all supplemental figures.
Supplemental Figure S5 from Cytokine-like Molecule CCDC134 Contributes to CD8+ T-cell Effector Functions in Cancer Immunotherapy
Authors: Huang Jing , Xiao Lin , Gong Xiaoting , Shao Wenwei , Yin Yanhui , Liao Qinyuan , Meng Yang , Zhang Yingmei , Ma Dalong , Qiu Xiaoyan
Published: April 2023

Involvement of CD4+ T cells in the induction of antitumor activity by CCDC134.
Supplemental Figure S4 from Cytokine-like Molecule CCDC134 Contributes to CD8+ T-cell Effector Functions in Cancer Immunotherapy
Authors: Huang Jing , Xiao Lin , Gong Xiaoting , Shao Wenwei , Yin Yanhui , Liao Qinyuan , Meng Yang , Zhang Yingmei , Ma Dalong , Qiu Xiaoyan
Published: April 2023

Potent antitumor activity of CCDC134 in vivo.
Supplemental Figure S3 from Cytokine-like Molecule CCDC134 Contributes to CD8+ T-cell Effector Functions in Cancer Immunotherapy
Authors: Huang Jing , Xiao Lin , Gong Xiaoting , Shao Wenwei , Yin Yanhui , Liao Qinyuan , Meng Yang , Zhang Yingmei , Ma Dalong , Qiu Xiaoyan
Published: April 2023

Identification of established CCDC134 transgenic mice.
Supplementary Video 2 from Axon Guidance Factor SLIT2 Inhibits Neural Invasion and Metastasis in Pancreatic Cancer
Authors: Göhrig Andreas , Detjen Katharina M. , Hilfenhaus Georg , Körner Jan L. , Welzel Martina , Arsenic Ruza , Schmuck Rosa , Bahra Marcus , Wu Jane Y. , Wiedenmann Bertram , Fischer Christian
Published: April 2023

AVI file - 2043KB, Recording of unidirectional migration of MiaPaCa cells along a contacted neurite from a DRG-tumor cell co-culture assay (Example 2).
Supplementary figure legends from USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen
Authors: Oosterkamp Hendrika M. , Hijmans E. Marielle , Brummelkamp Thijn R. , Canisius Sander , Wessels Lodewyk F.A. , Zwart Wilbert , Bernards René
Published: April 2023

Supplementary figure legends
Supplementary Table 2 from Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination
Authors: Hast Bridgid E. , Cloer Erica W. , Goldfarb Dennis , Li Heng , Siesser Priscila F. , Yan Feng , Walter Vonn , Zheng Ning , Hayes D. Neil , Major Michael B.
Published: April 2023

XLSX file - 891K, Filtered and unfiltered mass spectrometry data.
Supplementary Figure S6 from USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen
Authors: Oosterkamp Hendrika M. , Hijmans E. Marielle , Brummelkamp Thijn R. , Canisius Sander , Wessels Lodewyk F.A. , Zwart Wilbert , Bernards René
Published: April 2023

Figure S6. The USP9X knockdown tamoxifen classifier does not predict outcome after adjuvant chemotherapy in ERÃŽÂ± positive disease. The USP9X knockdown tamoxifen classifier was tested in a cohort of breast cancer patients (a subset from the 295 patients in the van de Vijver cohort (39)) with ERÃŽÂ± positive breast tumors treated with adjuvant chemotherapy only. Kaplan-Meier survival curves for distant metastasis free survival (DMFS) were generated, with p values indicated.
Supplementary Table 1 from Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination
Authors: Hast Bridgid E. , Cloer Erica W. , Goldfarb Dennis , Li Heng , Siesser Priscila F. , Yan Feng , Walter Vonn , Zheng Ning , Hayes D. Neil , Major Michael B.
Published: April 2023

XLSX file - 20K, Database of KEAP1 mutations in cancer.
Supplementary Figure S2 from USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen
Authors: Oosterkamp Hendrika M. , Hijmans E. Marielle , Brummelkamp Thijn R. , Canisius Sander , Wessels Lodewyk F.A. , Zwart Wilbert , Bernards René
Published: April 2023

Figure S2. QPCR validation of ChIP-seq data at 45 minutes ligand treatment. (A) Genome browser snapshots of ERÃŽÂ± chromatin binding events at the RARA and NRIP1 loci. Cells were ligand treated for 48 hours, prior to fixation. shGFP (blue) and shUSP9X (red) conditions were tested. Tag count and genomic coordinates are shown. (B) ERÃŽÂ± ChIP-QPCR validation of the genomic locations, indicated in A. Cells were ligand treated during 45 minutes prior to fixation. shGFP (white) and shUSP9X (black) conditions were tested. Enrichment over negative control region was assessed. Error bar shows SD values from triplicate measurements.
Supplementary Figure S1 from USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen
Authors: Oosterkamp Hendrika M. , Hijmans E. Marielle , Brummelkamp Thijn R. , Canisius Sander , Wessels Lodewyk F.A. , Zwart Wilbert , Bernards René
Published: April 2023

Figure S1. ERÃŽÂ± positive breast cancer cells are rescued from tamoxifen induced growth arrest by USP9X knockdown, but ERÃŽÂ± negative breast cancer cells are not. Knockdown of USP9X rescues tamoxifen-induced growth arrest in T47D cells. T47D cells were infected with the shRNA against USP9X recovered from the initial screen, pRS-USP9X II or pRS-GFP as control. Cells were cultured for 4-6 weeks in the presence of 1ÃŽÂ¼M 4OH-tamoxifen. When colonies appeared cells were fixed and subsequently stained. Plate confluency was determined by calculating the number of cell-covered pixels related to the total surface area.
Supplementary Figure 1 from Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination
Authors: Hast Bridgid E. , Cloer Erica W. , Goldfarb Dennis , Li Heng , Siesser Priscila F. , Yan Feng , Walter Vonn , Zheng Ning , Hayes D. Neil , Major Michael B.
Published: April 2023

PDF file - 603K, SQCC KEAP1 mutant characterization.
Supplementary Methods, Figures 1 - 9 from A Novel Radiotracer to Image Glycogen Metabolism in Tumors by Positron Emission Tomography
Authors: Witney Timothy H. , Carroll Laurence , Alam Israt S. , Chandrashekran Anil , Nguyen Quang-Dé , Sala Roberta , Harris Robert , DeBerardinis Ralph J. , Agarwal Roshan , Aboagye Eric O.
Published: April 2023

PDF file - 915K, Fig. S1 shows Glycogen Synthase 1 knockdown by shRNA; Fig. S2 Depicts correspondence between punctate 2-NBDG fluorescence and immunofluorescence staining with an anti-glycogen antibody; Fig. S3 illustrates changes in punctate 2-NBDG fluorescence during cell division; Fig. S4 shows the Effect of HEY Rab25 cell density on cellular senescence; Fig. S5 indicates heterogeneous 2-NBDG staining of HEY Rab25 tumor spheroids; Fig. S6 confirms 18F-NFTG radiotracer stability; Fig S7 is 18F-FDG and 18F-NFTG blood retention; Fig. S8 compares 18F-NFTG and 18F-FDG uptake in turpentine-induced inflammatory tissue; Fig. S9 compares glycogen content in the stationary phase of growth of 8 human tumour cell lines from ovarian, breast colorectal and lung adenocarcinoma.
Data Supplement from miR149 Functions as a Tumor Suppressor by Controlling Breast Epithelial Cell Migration and Invasion
Authors: Bischoff Annabell , Huck Bettina , Keller Bettina , Strotbek Michaela , Schmid Simone , Boerries Melanie , Busch Hauke , Müller Dafne , Olayioye Monilola A.
Published: April 2023

Supplemental Table 1 lists predicted miR-149 target genes according to their KEGG pathway annotation. Supplemental Figure 1 shows the effect of miR-149 expression on adhesion and spreading. characteristics of BT549, Hs578T, and MDA-MB-436 cell lines. Supplemental Figure 2 demonstrates the effect of mir-149 expression on cell spreading and migration, and Rac activity in PC3 prostate cancer cells. Supplemental Figure 3 shows that miR-149 expression does not alter total Rac protein levels. Supplemental Figure 4 shows the levels of miR-149 in MDA-MB-231 cells upon transient transfection.
Data Supplement from miR149 Functions as a Tumor Suppressor by Controlling Breast Epithelial Cell Migration and Invasion
Authors: Bischoff Annabell , Huck Bettina , Keller Bettina , Strotbek Michaela , Schmid Simone , Boerries Melanie , Busch Hauke , Müller Dafne , Olayioye Monilola A.
Published: April 2023

Supplemental information on antibodies and reagents, and supplemental figures legends.
Supplementary Figures 1 - 8 from HDAC2 Provides a Critical Support to Malignant Progression of Hepatocellular Carcinoma through Feedback Control of mTORC1 and AKT
Authors: Noh Ji Heon , Bae Hyun Jin , Eun Jung Woo , Shen Qingyu , Park Se Jin , Kim Hyung Seok , Nam Boas , Shin Woo Chan , Lee Eun Kyung , Lee Kyungbun , Jang Ja-Jun , Park Won Sang , Lee Jung Young , Nam Suk Woo
Published: April 2023

PDF file - 3559KB, Supplementary Figure S1. HDAC2 gene expression and GSEA results for genes up-regulated in the HDAC2-associated signature in HCC large cohort studies. Supplementary Figure S2. Representative immunohistochemical staining of phospho-mTOR, mTOR, and HDAC2 expression in non-cancerous hepatic cells and HCC cells. Supplementary Figure S3. The ectopic overexpression of HDAC2 induces AKT activation. Supplementary Figure S4. mRNA expression data of genes encoding kinase or phosphatase in the phosphoinositide signaling pathway. Supplementary Figure S5. A schematic illustration of the phosphoinositide signaling pathway regulated by HDAC2 in HCC cells. Supplementary Figure S6. HDAC2 induced the migration of liver cancer cells. Supplementary Figure S7. Synergistic anti-growth effect of Sorafenib and HDAC2 knock-down on HCC cells. Supplementary Figure S8. Growth factor-induced HDAC2 mediates a positive feedback loop to mTORC1 stabilization and AKT activation.
Supplementary Methods and Figure Legends from BRCA2 Phosphorylated by PLK1 Moves to the Midbody to Regulate Cytokinesis Mediated by Nonmuscle Myosin IIC
Authors: Takaoka Miho , Saito Hiroko , Takenaka Katsuya , Miki Yoshio , Nakanishi Akira
Published: April 2023

PDF file - 153K
Supplementary Table 1 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling
Authors: Pishas Kathleen I. , Neuhaus Susan J. , Clayer Mark T. , Schreiber Andreas W. , Lawrence David M. , Perugini Michelle , Whitfield Robert J. , Farshid Gelareh , Manavis Jim , Chryssidis Steve , Mayo Bronwen J. , Haycox Rebecca C. , Ho Kristen , Brown Michael P. , D'Andrea Richard J. , Evdokiou Andreas , Thomas David M. , Desai Jayesh , Callen David F. , Neilsen Paul M.
Published: April 2023

PDF file - 72K, Primers utilised in this study.
Supplementary Figure 6 from BRCA2 Phosphorylated by PLK1 Moves to the Midbody to Regulate Cytokinesis Mediated by Nonmuscle Myosin IIC
Authors: Takaoka Miho , Saito Hiroko , Takenaka Katsuya , Miki Yoshio , Nakanishi Akira
Published: April 2023

PDF file - 98K, NM-IIC-ATPase activity enhanced in the presence of BRCA2 is required for IIC-ring formation. (Related to Figure 5).
Supplementary Figure 5 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling
Authors: Pishas Kathleen I. , Neuhaus Susan J. , Clayer Mark T. , Schreiber Andreas W. , Lawrence David M. , Perugini Michelle , Whitfield Robert J. , Farshid Gelareh , Manavis Jim , Chryssidis Steve , Mayo Bronwen J. , Haycox Rebecca C. , Ho Kristen , Brown Michael P. , D'Andrea Richard J. , Evdokiou Andreas , Thomas David M. , Desai Jayesh , Callen David F. , Neilsen Paul M.
Published: April 2023

PDF file - 58K, GADD45A and sarcoma pathology.
Supplementary Figure 4 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling
Authors: Pishas Kathleen I. , Neuhaus Susan J. , Clayer Mark T. , Schreiber Andreas W. , Lawrence David M. , Perugini Michelle , Whitfield Robert J. , Farshid Gelareh , Manavis Jim , Chryssidis Steve , Mayo Bronwen J. , Haycox Rebecca C. , Ho Kristen , Brown Michael P. , D'Andrea Richard J. , Evdokiou Andreas , Thomas David M. , Desai Jayesh , Callen David F. , Neilsen Paul M.
Published: April 2023

PDF file - 43K, Induction of GADD45A and BBC3 is associated with Nutlin-3a induced apoptosis.
Supplementary Figure 3 from Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling
Authors: Pishas Kathleen I. , Neuhaus Susan J. , Clayer Mark T. , Schreiber Andreas W. , Lawrence David M. , Perugini Michelle , Whitfield Robert J. , Farshid Gelareh , Manavis Jim , Chryssidis Steve , Mayo Bronwen J. , Haycox Rebecca C. , Ho Kristen , Brown Michael P. , D'Andrea Richard J. , Evdokiou Andreas , Thomas David M. , Desai Jayesh , Callen David F. , Neilsen Paul M.
Published: April 2023

PDF file - 67K, TP53 pathway alterations do not mediate sarcoma cytostatic response to Nutlin-3a.
Supplementary Figure 2 from BRCA2 Phosphorylated by PLK1 Moves to the Midbody to Regulate Cytokinesis Mediated by Nonmuscle Myosin IIC
Authors: Takaoka Miho , Saito Hiroko , Takenaka Katsuya , Miki Yoshio , Nakanishi Akira
Published: April 2023

PDF file - 95K, The subcellular localization of the NM-IIC during cytokinesis, and its interaction with BRCA2 (Related to Figure 2).
Supplementary Figure 4 from High Numbers of Differentiated Effector CD4 T Cells Are Found in Patients with Cancer and Correlate with Clinical Response after Neoadjuvant Therapy of Breast Cancer
Authors: Péguillet Isabelle , Milder Maud , Louis Delphine , Vincent-Salomon Anne , Dorval Thierry , Piperno-Neumann Sophie , Scholl Suzy M. , Lantz Olivier
Published: April 2023

PDF file - 323KB, The chCD4 T cells found in breast cancer patients treated by neo-adjuvant chemotherapy are similar to those found in mUM patients.
Supplementary Table 4 from PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen–Specific CD8+ T Cells Induced by Melanoma Vaccines
Authors: Fourcade Julien , Sun Zhaojun , Pagliano Ornella , Chauvin Joe-Marc , Sander Cindy , Janjic Bratislav , Tarhini Ahmad A. , Tawbi Hussein A. , Kirkwood John M. , Moschos Stergios , Wang Hong , Guillaume Philippe , Luescher Immanuel F. , Krieg Arthur , Anderson Ana C. , Kuchroo Vijay K. , Zarour Hassane M.
Published: April 2023

PDF file - 64K, Toxicities and clinical responses.
Supplementary Figure 3 from High Numbers of Differentiated Effector CD4 T Cells Are Found in Patients with Cancer and Correlate with Clinical Response after Neoadjuvant Therapy of Breast Cancer
Authors: Péguillet Isabelle , Milder Maud , Louis Delphine , Vincent-Salomon Anne , Dorval Thierry , Piperno-Neumann Sophie , Scholl Suzy M. , Lantz Olivier
Published: April 2023

PDF file - 182KB, The effector CD8 T cells found increased in cancer patients comprise oligoclonal expansions and their level is correlated with the number of effector chCD4 T cells. Follow up and characterization of chCD4 and effector CD8 T cells in 2 patients with gastro esophageal cancers treated by chemo-radiotherapy followed by surgery.
Supplementary Table 3 from PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen–Specific CD8+ T Cells Induced by Melanoma Vaccines
Authors: Fourcade Julien , Sun Zhaojun , Pagliano Ornella , Chauvin Joe-Marc , Sander Cindy , Janjic Bratislav , Tarhini Ahmad A. , Tawbi Hussein A. , Kirkwood John M. , Moschos Stergios , Wang Hong , Guillaume Philippe , Luescher Immanuel F. , Krieg Arthur , Anderson Ana C. , Kuchroo Vijay K. , Zarour Hassane M.
Published: April 2023

PDF file - 78K, Ex vivo frequencies of cytolytic molecule-expressing and CD107a+ NY-ESO-1 157-165-specific CD8+ T cells before and after vaccination with either MHC class I peptide alone (arm 1), or both MHC class I and class II peptides (arm 2).
Supplementary Figure 1 from High Numbers of Differentiated Effector CD4 T Cells Are Found in Patients with Cancer and Correlate with Clinical Response after Neoadjuvant Therapy of Breast Cancer
Authors: Péguillet Isabelle , Milder Maud , Louis Delphine , Vincent-Salomon Anne , Dorval Thierry , Piperno-Neumann Sophie , Scholl Suzy M. , Lantz Olivier
Published: April 2023

PDF file - 107KB, chCD4 T cells are not Treg and chCD4 T cells comprise mostly effector cells in mUM patients.
Supplementary Table 1 from PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen–Specific CD8+ T Cells Induced by Melanoma Vaccines
Authors: Fourcade Julien , Sun Zhaojun , Pagliano Ornella , Chauvin Joe-Marc , Sander Cindy , Janjic Bratislav , Tarhini Ahmad A. , Tawbi Hussein A. , Kirkwood John M. , Moschos Stergios , Wang Hong , Guillaume Philippe , Luescher Immanuel F. , Krieg Arthur , Anderson Ana C. , Kuchroo Vijay K. , Zarour Hassane M.
Published: April 2023

PDF file - 63K, Patient demographics.
Supplementary Table 1 from Alterations of Choline Phospholipid Metabolism in Endometrial Cancer Are Caused by Choline Kinase Alpha Overexpression and a Hyperactivated Deacylation Pathway
Authors: Trousil Sebastian , Lee Patrizia , Pinato David J. , Ellis James K. , Dina Roberto , Aboagye Eric O. , Keun Hector C. , Sharma Rohini
Published: April 2023

Supplementary Table 1 contains a list of all metabolic alterations detected in endometrial cancer.
Supplementary Table 2 from Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells
Authors: Satelli Arun , Mitra Abhisek , Cutrera Jeffry J. , Devarie Marcos , Xia Xueqing , Ingram Davis R. , Dibra Denada , Somaiah Neeta , Torres Keila E. , Ravi Vinod , Ludwig Joseph A. , Kleinerman Eugenie S. , Li Shulin
Published: April 2023

PDF file - 2029KB, CTC enumeration in different Sarcoma cancer patient samples.
Supplementary Tables 1 - 2 from A Systems Biology Approach Identifies Effective Tumor–Stroma Common Targets for Oral Squamous Cell Carcinoma
Authors: Meng Wenxia , Wu Yun , He Xin , Liu Chuanxia , Gao Qinghong , Ge Lin , Wu Lanyan , Liu Ying , Guo Yiqing , Li Xiaoyu , Liu Yurong , Chen Sixiu , Kong Xiangli , Liang Zhi , Zhou Hongmei
Published: April 2023

PDF file - 102K, Immunostaining of SPP1 in the 127 OSCC tissues in TG2: correlation with clinicopathological parameters (S1); Functional annotation of SPP1Net (S2).
Supplementary Figure 3 from Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells
Authors: Satelli Arun , Mitra Abhisek , Cutrera Jeffry J. , Devarie Marcos , Xia Xueqing , Ingram Davis R. , Dibra Denada , Somaiah Neeta , Torres Keila E. , Ravi Vinod , Ludwig Joseph A. , Kleinerman Eugenie S. , Li Shulin
Published: April 2023

PDF file - 660KB, Detection of CD31, an endothelial cell marker on CTC.
Supplementary Figure Legend from IRP2 Regulates Breast Tumor Growth
Authors: Wang Wei , Deng Zhiyong , Hatcher Heather , Miller Lance D. , Di Xiumin , Tesfay Lia , Sui Guangchao , D'Agostino Ralph B. , Torti Frank M. , Torti Suzy V.
Published: April 2023

PDF file - 59K
Supplementary Figure 4 from YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway
Authors: Zhao Yulei , Khanal Prem , Savage Paul , She Yi-Min , Cyr Terry D. , Yang Xiaolong
Published: April 2023

PDF file - 547KB, Response of MCF10A cells expressing wild-type and mutant YAP to Cisplatin.
Supplementary Figure 2 from YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway
Authors: Zhao Yulei , Khanal Prem , Savage Paul , She Yi-Min , Cyr Terry D. , Yang Xiaolong
Published: April 2023

PDF file - 1914KB, Cdk1 is responsible for Taxol-induced TAZ phosphorylation and degradation.
Supplementary Figure 4 from NUP98 Fusion Oncoproteins Promote Aneuploidy by Attenuating the Mitotic Spindle Checkpoint
Authors: Salsi Valentina , Ferrari Silvia , Gorello Paolo , Fantini Sebastian , Chiavolelli Francesca , Mecucci Cristina , Zappavigna Vincenzo
Published: April 2023

PDF - 1659K, Supplementary Figure 4. siRNA knock-down experiments. A, Immunoblots showing the effects of siRNAs on CDC20 or CDH1 protein expression. Anti-betaactin was used as a loading control. Graphs representing immunoblot quantitations are shown on the right side. B, Cell cycle analysis using propidium iodide staining and flow citometry on control siRNA-treated HEK293 cells (left side), and on siRNA-treated HEK293 cells expressing the NUP98-HOXD13 oncogene (right side).
Supplementary Figure Legend from A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells
Authors: Barsoum Ivraym B. , Smallwood Chelsea A. , Siemens D. Robert , Graham Charles H.
Published: April 2023

PDF file - 73K
Supplementary Figure 1 from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: April 2023

PDF file - 375K, The relative ADAR1 expression level in nine ESCC cell lines, as detected by QPCR.
Supplementary Movie 6 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

MP4 file - 1833K, Supplementary movie S6: time-lapse video-microscopy with a 10x magnification objective, of Lu1205 cells plated on plastic 48 hr after si ICAT transfection.
Supplementary Movie 5 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

MP4 file - 2929K, Supplementary movie S5: time-lapse video-microscopy with a 10x magnification objective, of Mel501 cells plated on plastic 48 hr after si ICAT transfection.
Supplemental Figure S2 from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: April 2023

Correlation between the expression level of ADAR1 and the editing level of AZIN1 (left panel) or FLNB (right panel) among nine ESCC cell lines.
Supplemental Figure Legends from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: April 2023

Legend for Supplemental Figures S1-S4
Supplementary Figure Legends from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression
Authors: Wen Yu , Li Jiadong , Koo Jasmine , Shin Seung-Shick , Lin Yong , Jeong Byeong-Seon , Mehnert Janice M. , Chen Suzie , Cohen-Sola Karine A. , Goydos James S.
Published: April 2023

PDF file - 42KB
Supplementary Figure 2 from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression
Authors: Wen Yu , Li Jiadong , Koo Jasmine , Shin Seung-Shick , Lin Yong , Jeong Byeong-Seon , Mehnert Janice M. , Chen Suzie , Cohen-Sola Karine A. , Goydos James S.
Published: April 2023

PDF file - 612KB, Supplemental Figure 2: IL8 and VEGF levels in conditioned media were decreased by treatment with inhibitors of GRM1/AKT/mTOR/HIF1 signaling.
Supplementary Figure 5 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

PDF file - 147K, Exogenous ICAT expression does not affect the morphology of Mel501 and Skmel3 cells.
Supplementary Figure 2 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: April 2023

PDF file - 117K, Transient exogenous ICAT expression does not affect the proliferation rates and the viability of Lu1205, Mel501 and Skmel3 cells.
Supplementary Video 2 from miR-28-5p Promotes Chromosomal Instability in VHL-Associated Cancers by Inhibiting Mad2 Translation
Authors: Hell Michael P. , Thoma Claudio R. , Fankhauser Niklaus , Christinat Yann , Weber Thomas C. , Krek Wilhelm
Published: April 2023

MOV file - 714KB, Suppl. Movie 2: Analysis of nocodazole-induced mitotic arrest in HeLa cells expressing miR-28-5p. Time-lapse (5 min interval, total time: 14h) movies of nocodazole-arrested HeLa H2B-GFP cells transfected with miR-28-5p.
Supplementary Tables S1-S5 from Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma
Authors: Gopal Y.N. Vashisht , Rizos Helen , Chen Guo , Deng Wanleng , Frederick Dennie T. , Cooper Zachary A. , Scolyer Richard A. , Pupo Gulietta , Komurov Kakajan , Sehgal Vasudha , Zhang Jiexin , Patel Lalit , Pereira Cristiano G. , Broom Bradley M. , Mills Gordon B. , Ram Prahlad , Smith Paul D. , Wargo Jennifer A. , Long Georgina V. , Davies Michael A.
Published: April 2023

Supplementary Tables S1-S5. Table S1. Patients in the MIA/WH cohort treated with BRAF and/or MEK inhibitors. Table S2. Patients in the MGH patient cohort were treated with the BRAF inhibitor vemurafenib or a combination of BRAF and MEK inhibitors (dabrafenib+trametinib). Table S3. The following melanoma cell lines with known BRAF and NRAS mutation status were seeded in 96 well plates overnight and treated with increasing concentrations (dose range 9nM-6.5mM) of selumetinib (SEL), AZD8055 or their combination. Table S4. Mutations detected in the selumetinib-resistant A375 and WM35 cell line clones compared to their parental cell lines. Table S5. Hugo gene symbols, chromosomal location and gene names of the 202 genes represented in the T200 exon sequencing panel.