bluuebunny/crossref_metadata_2025 huggingface dataset:
The Disclosure of Sustainability Report in Energy and Financial Sector Companies of Indonesia and Malaysia Sharia Securities List
Authors: Aneta Rakhmawati  , Oktria Fani Rahmasari
Published: February 2025

This study aims to determine the level of sustainability report disclosure in energy and financial sector companies of Indonesia and Malaysia sharia securities list in 2021. Sustainability report is an important measurement tool for the government and stakeholders to see the extent of a company's sustainability performance. This study focuses on analyzing the level of sustainability report disclosure on economic, environmental, and social topics based on the GRI Standards by using qualitative-descriptive research type. The number of samples in this study is 21 companies which was taken based on purposive sampling. The results of this study indicate that the average of sustainability report disclosure for 2021 in the energy sector is higher than the disclosure score made by financial sector. The average disclosure of the energy sector is 41,45%, while the financial sector is 27,53%. Indonesia obtained the highest score for energy sector while Malaysia obtained the highest score for financial sector. The highest disclosure rate for financial sector is owned by Bursa Malaysia Bhd with a score 35,96%. Meanwhile, the highest disclosure rate for the energy sector is occupied by PT Perusahaan Gas Negara Tbk with a total score 77,53%.
Pengukuran Tingkat Kesehatan OPZ terhadap Aspek Keuangan dan Manajemen (Studi Kasus pada Lazismu Al Jihad Banjarmasin)
Authors: Mairijani  , Putri Eka Yunisa
Published: February 2025

The purpose of this research is to assess the health of Lazismu Al Jihad in terms of financial and management aspects using the OPZ Health Index (IKOPZ) as the measurement tool. This descriptive research employs a quantitative approach, utilizing primary data from interviews and secondary data from Lazismu Al Jihad's 2022 financial reports. The analysis technique applied is the OPZ Health Index (IKOPZ), calculated through a multi-stage weighted index method. The research findings indicate that Lazismu Al Jihad achieved a rank of 2 in both financial and management aspects. This signifies that Lazismu Al Jihad demonstrates strong financial performance with high effectiveness and efficiency in managing ZIS funds, enabling growth. Additionally, Lazismu Al Jihad shows good governance quality, adequate risk management, and adherence to prevailing sharia principles. Overall, the study concludes that Lazismu Al Jihad's health level is categorized as good with a rank of 2, indicating effective organizational management.
ҚҰРАМЫ БАЙЫТЫЛҒАН НАННЫҢ ЖАҢА ТҮРІН ӨНДІРУ ТЕХНОЛОГИЯСЫН ЖАСАУ
Authors: Кобжасарова З.И. , Касымова М.К. , Орымбетова Г.Э.
Published: February 2025

Мақалада қарақұмық ұнымен байытылған нан өнімдерінің зерттеу нәтижелері келтірілген. Авторлармен қарақұмық ұнымен байытылғаннан өнімінің жаңа технологиясы ұсынылған. Көрсетілгендей, бұл жаңа нан өнімінде кең минералды құрам бар. Мақала тағамдық құндылығы жоғарынан өнімдерін әзірлеу бойынша зерттеулерге арналған. Зерттеудің мақсаты отандық байытқыштарды қолдана отырып, ассортиментті кеңейту үшін шағынкәсіпорындарға ұсынылуы мүмкін, қарақұмық ұнын қосып, жеделдетілген технология бойынша нан өнімдерін әзірлеу болды. Дайын бұйымдардыңорганолептикалық және физика-химиялық қасиеттерін анықтау бойынша зерттеулер жүргізілді, бұйымдардың тағамдық құндылығы мен химиялық құрамы анықталды. Ең жақсы тұтынушылық қасиеттерді сақтау және адамның күнделікті қоректік заттарға деген қажеттілігін қанағаттандыру үшін қарақұмық ұнының ең жақсы мөлшері белгіленді. Осылайша, нан өнімдерініңрецептурасына профилактикалық тамақ өнімдерін жасау мақсатында табиғи қоспаларды енгізу нан пісіру өнеркәсібін дамытудың өзекті бағыты болыптабылады. Зерттеу әдістемесін қолдана отырып, нан сынамаларының физика-химиялық көрсеткіштері анықталды. Зерттеу әдістерінің қорытындысыбойынша таңдау үлгісі, яғни жалпы бидай ұнының көлемінен 15 % қарақұмық ұны қосылған нан өнімі қарастырылды. Сондай-ақ өсімдік қоспаларыменбайытылған нан өнімінің құрамында минералды заттардың мөлшері артты.
Intelligent Detection of Potholes Using SSD Algorithm and Auto-Alert Notification System for User
Authors: Kumar Harish
Published: February 2025

Potholes are cracks on the road’s surface that leave a hole behind it. Reporting potholes to accountable bodies at an early stage can save many lives. Therefore, timely inspection and maintenance of potholes are required for smooth transportation. Traditional pothole detection methods are labor-intensive and time-consuming. This research focuses on such gaps and presents an intelligent detecting system that uses a smartphone camera, sensors, and gyroscope for real-time detection of potholes. The proposed model covers two essential functions: i). automated identification of potholes, and ii). notifying users to escape probable accidents. The “Single Shot Multi-Box Detector (SSD)” technique trains the pothole image datasets. For developing the dataset, pothole images are taken and labeled with TensorFlow object detection API. The method achieved 90% accuracy in detecting potholes in used image datasets. Study outcomes can help stakeholders get road profiling information and alerts about potholes for smooth road transportation.
Persepsi Masyarakat terhadap Pelayanan Pembayaran Pajak Kendaraan Bermotor secara Online
Authors: Widodo Wahyu , Mirnawati Mirnawati
Published: February 2025

This study aims to determine the community's perception of online motor vehicle tax payment services, regarding simplicity, clarity, certainty of completion time, employee responsibility, completeness of facilities and infrastructure, employee behavior, and comfort. This research uses qualitative descriptive methods, while data collection is carried out by observation, interview, and documentation techniques. The data analysis technique used is an interactive analysis including data collection, data reduction, data presentation, and then concluding. The validity of the data used is the source triangulation technique and the method triangulation. The results of this study show that the perception of the Metro City community towards online motor vehicle tax payment services is quite good. However, there is still a need for additional information boards. A longer queue and completion time in paying their motor vehicle tax makes them use third-party services.
ВПЛИВ ПРОФЕСІЙНОЇ ЕТИКИ БУХГАЛТЕРА, ФІНАНСИСТА І ПОДАТКІВЦЯ НА ФОРМУВАННЯ ДОВІРИ ДО ФІНАНСОВОЇ ЗВІТНОСТІ
Authors: КОРКУШКО Олег Никодимович , КУШНІР Людмила Анатоліївна , ШЕВЧУК Наталія Станіславівна
Published: February 2025

У статті досліджується роль професійної етики фахівців у сфері бухгалтерського обліку, фінансів та оподаткування у формуванні довіри до фінансової звітності. Акцент зроблено на аналізі ключових етичних принципів, таких як чесність, об’єктивність, конфіденційність, професійна компетентність і належна обачність, які є основою прозорості та достовірності фінансової інформації. Увага приділяється важливості дотримання професійних стандартів у сучасних умовах глобалізації, коли економічні процеси ускладнюються, а обсяг фінансових операцій зростає. Розглянуто виклики, з якими стикаються фахівці через тиск з боку керівництва, високий рівень конкуренції та спокусу швидкого збагачення. Порушення етичних норм у цих умовах стає причиною корупції, фінансових махінацій і спотворення звітності, що підриває довіру до професії та економічної системи в цілому. У статті наведено приклади впливу етичних порушень на репутацію компаній та їхній фінансовий стан, зокрема розглянуто випадок компанії Enron. Особливу увагу приділено Міжнародному Кодексу етики професійних бухгалтерів, розробленому Міжнародною федерацією бухгалтерів (IFAC), який встановлює глобальні етичні стандарти для фахівців у сфері бухгалтерії та фінансів. Цей документ розглядається як ефективний інструмент, що забезпечує єдність етичних вимог на міжнародному рівні, сприяє запобіганню фінансовим махінаціям і зміцнює довіру до фінансової звітності. У статті підкреслено важливість навчання та сертифікації як інструментів формування етичної культури. Розглянуто роль освітніх програм і сертифікаційних курсів, які спрямовані на вивчення етичних стандартів та аналіз практичних кейсів, що допомагають фахівцям приймати обґрунтовані рішення у складних ситуаціях. Особливий акцент зроблено на необхідності постійного вдосконалення професійних знань для підтримки високих стандартів етичної поведінки.
Individual variation in animal communication: from species averages to unique voices
Authors: Lombrey Angele , Fröhlich Marlen
Published: February 2025

The comparative study of the communicative behaviour of non-human animals, especially primates, has yielded crucial insights into the evolution of human language. This research, mostly focused on the species and population level, has helped to understand the various socio-ecological factors that shape communication systems. However, despite the inherent flexibility of human communication, the impact of individual variation on non-human communication systems has often been overlooked, as have its potential insights into the roots of human language. While the eco-evolutionary relevance of genetic and phenotypic differences between individuals is well established, animal communication studies traditionally focus on group means and treat outliers as noise. In this review, we address this gap by providing a comprehensive overview of the sources of individual variation in animal communicative behaviour (e.g. physiological, sociodemographic or personality traits) in numerous parameters such as signal forms, repertoires, and strategies of use. In particular, recent evidence from comparative work underscores the potential evolutionary implications of individual plasticity in communicative behaviour. Thus, we argue for an explicit focus on within-individual variation and propose a way to advance the study of animal communication through multi-level approaches that consider intrinsic, environmental as well as between- and within-individual variation together. Such approaches not only refine our perception of complexity in animal communication systems and implications for social evolution, but also help to trace the evolutionary trajectory of human language through comparative studies.
The Benefits of Extensive Reading for Moroccan EFL University Students: Insights from a Case Study
Authors: Larhmaid Maryem
Published: February 2025

This study examines the impact of an extensive reading program (Cycle Licence d’Education) on the vocabulary knowledge, reading comprehension, and critical thinking skills of 88 Moroccan English as a Foreign Language (EFL) students. Over 14 weeks, with 120-minute sessions weekly, participants engaged with texts from various fields such as history, philosophy, sociology, psychology, education, politics, religion, and science. Using a quantitative research design, pre- and post-assessments were conducted to measure the outcomes of the Extensive Reading Module. Results showed a significant improvement in vocabulary, with two-thirds of the participants (66%) reporting considerable progress in both vocabulary acquisition and its practical application. The program also affected positively reading comprehension, as 93% of students felt confident in their ability to read and understand complex texts. Furthermore, 84% of students acknowledged that the program significantly enhanced their critical thinking abilities after engaging with literary and academic materials. These findings provide valuable insights for EFL/ESL educators and curriculum designers, showing how extensive programs can help build language skills and promote critical engagement with academic and literary texts.
Surrealismo, paisaje y decepción en la obra de Jorge Cuesta: puntos de encuentro con lo “Real maravilloso americano” de Alejo Carpentier
Authors: Ceballos Ramírez Diego C.
Published: February 2025

Jorge Cuesta y Alejo Carpentier se conocieron en París en 1928 cuando el surrealismo se erigía como la más dominante vanguardia del momento. De la relación de Cuesta con el surrealismo surgieron textos con los que el autor pone en tela de juicio la estética surrealista. En ese sentido, este trabajo explora la relación entre estos dos autores a partir de su viaje a París y la distancia que posteriormente Carpentier contrajo con el surrealismo. Asimismo, estudiamos afinidades intelectuales entre los dos autores por medio de conceptos como la decepción del paisaje y la vuelta a las raíces.
BCL2 inhibition in adult acute lymphoblastic leukemia: ready for primetime?
Authors: Jain Nitin , Jabbour Elias , Konopleva Marina
Published: February 2025

Not available.
La improvisación que genera comunidad. El movimiento social que ha revitalizado la bertsolaritza
Authors: Zubiri-Esnaola Harkaitz
Published: February 2025

El canto improvisado fue común en numerosos lugares del mundo. Sin embargo, aunque hoy en día se sigue practicando, es difícil encontrar un canto improvisado que tenga mucho público. La bertsolaritza, el arte de cantar versos improvisados, en euskera, con rima y métrica, es un caso muy particular. Tras años de declive, el número de personas improvisadoras, de eventos y el volumen de público han crecido muy significativamente estas cinco últimas décadas. Este artículo expone algunas de las claves que han hecho esto posible. Durante el siglo XX hubo varios intentos de revitalizar la bertsolaritza, pero fue el movimiento que comenzó con más fuerza en la década de 1980 el que respondió de manera más efectiva, constituyéndose como movimiento social y creando espacios para la participación, transmisión y documentación; ha articulado a personas creadoras y aficionadas, voluntariado y profesionales de las asociaciones; ha promovido grandes movilizaciones en torno a la bertsolaritza; y ha utilizado los medios de comunicación para promocionarse y llevarla a los hogares. La clave de su supervivencia y expansión no fue simplemente organizar espectáculos, sino más bien organizar un movimiento social en torno a un proyecto sociocultural. El artículo finaliza reflexionando sobre algunos de los retos a los que se enfrenta la bertsolaritza a medio plazo.
E-Learning dalam Kajian Pendidikan Agama Islam di Perguruan Tinggi pada Abad ke-21
Authors: Ulya Vita Fitriatul , Abidin Zainal
Published: February 2025

The 21st century learning paradigm has undergone a significant shift, demanding active participation from both educators and students in technology-based learning processes. This holds for the study of Islamic Religious Education (IRE), a mandatory component of the higher education curriculum. This literature research aims to highlight the urgency of leveraging e-learning in higher education for the study of IRE as a response to the challenges of the 21st century. The methodology employed in this study is literature research, examining 31 articles published in the last 5 years related to e-learning, IRE studies, and the learning paradigms of the 21st century. The research findings indicate the importance of e-learning in the study of IRE, providing students with learning experiences through digitalization and technology. Several learning management systems (LMS) are reviewed in this paper, such as Zoom Cloud Meeting, Google Classroom, Moodle, and Schoology. Through the features offered by these platforms, educators can innovate in managing digital-based learning, facilitating students' access to IRE learning materials, encouraging discipline in assignment submission, and enabling independent learning without constraints of space and time.
Prinsip Pendidikan Moderasi Beragama di Pesantren An-Nawawi Purworejo
Authors: Madum Mohamad , Daimah Daimah
Published: February 2025

This research aims to reveal the learning material and implementation of the internalization of religious moderation at the An-Nawawi Purworejo Islamic boarding school (pesantren) through the five basic principles of religious moderation. The research method used is qualitative research. In collecting data, the researcher used observation, interviews, and documentation. The data that has been obtained is analyzed using the processes of data condensation, data presentation, and data verification. The result is that religious moderation has been achieved through the five basic principles of religious moderation, which are carried out by providing learning material including an understanding of religious values, tolerance, inter-religious dialogue, developing critical thinking skills, and emphasizing universal values. The learning method involves values education, Islamic teacher exemplariness, discussions in religious harmony forums, and technology and social media utilization.
The Compensation and Work Motivation of Madrasah Tsanawiyah Teachers: A Correlational Analysis
Authors: Cholizah Syfa Nurul , Juhji Juhji , Mansur Mansur
Published: February 2025

This study examines how Madrasah Tsanawiyah teachers' motivation for their work and pay interact. A survey method was employed in this study. Thirty teachers from Madrasah Tsanawiyah Cibeber Lebak Regency participated in this study. A Likert scale questionnaire with five verified response alternatives was used as the study tool. The teacher used a printed copy of the instrument to collect the instruments. According to the study, teacher work motivation is 74.80% in the very good category, and compensation is in the very good category with an achievement level of 74.78%. The correlation coefficient r is 0.70, indicating a significant and sufficient connection. Of the elements influencing teacher job motivation, 49% are related to compensation, and the remaining 51% are determined by additional factors not included in this research and which need more investigation. The study's findings indicate that remuneration and work motivation are significantly correlated. The study's conclusions suggest boosting teachers' enthusiasm at work by giving them more money through various supportive initiatives.
Pengembangan Program Edupreneurship dalam Menumbuhkan Jiwa Kewirausahaan di Sekolah Menengah Kejuruan
Authors: Wijayanti Reny Widya , Tyas Zuhriana Widya Rahayu Ning , Hikmawati Hanifah
Published: February 2025

The unemployment rate is still relatively high, and interest in entrepreneurship is still relatively low. It encourages schools to develop edupreneurship programs so that students have an entrepreneurial spirit and additional skills to prepare for life in the future. This research aims to determine various edupreneurship programs at Public Vocational High School (SMK Negeri) 1 Ngawi, the school principal's efforts in developing edupreneurship programs, and the factors inhibiting and supporting their development. This research uses a qualitative method that utilizes primary (interviews) and secondary data (documentation of activities and observations). The research results show three significant findings: First, SMK Negeri 1 Ngawi has five entrepreneurship programs: entrepreneurship lessons, P5, service unit, teaching factory, and industrial visits. Second, the school principal strives to develop edupreneurship programs per existing regulations, encourages teachers and students to participate in entrepreneurial activities, and evaluates ongoing activities. Third, inhibiting factors include policy regulations, lack of financial support, lack of consumers, and technological challenges. Meanwhile, the supporting factors are the students' willingness to become entrepreneurs, the existence of UPJ and teaching factories, and the strategic position of the school.
Pendekatan Social Emotional dalam Pembelajaran Pendidikan Agama Islam untuk Meminimalisir Bullying di Sekolah
Authors: Rahmat Rahmat , Nurhidayati Titin
Published: February 2025

Acts of bullying in every level of education (at the elementary, middle school and high school) are currently a national news issue. Victims of bullying can experience severe trauma and the perpetrators of bullying can end up dropping out of school. Finding this latest phenomenon, this research aims to examine the Social Emotional Approach in Islamic Religious Education Learning to minimize bullying at school. With a qualitative approach and in-depth literature review, this research shows that the Social Emotional Approach in Learning Islamic Religious Education can minimize bullying in schools. As for the findings from the results of this research, the Social Emotional Approach in Islamic Religious Education Learning must be implemented by utilizing several learning dimensions, namely, 1) The Social Emotional Approach utilizes Islamic Religious Education material based on five Social Emotional competencies, 2) The Social Emotional Approach is supported by the Group learning method Investigation, and 3) Social Emotional Approach is also strengthened by learning techniques a) Lecture, b) Discussion, and c) Question and answer.
Navigating Islamic Education for National Character Development: Addressing Stagnation in Indonesia's Post-Conservative Turn Era
Authors: Hosaini Hosaini , Ni’am Syamsun , Khamami Akhmad Rizqon
Published: February 2025

This research investigates the role of the Islamic education system in shaping the nation's character and addresses the challenges threatening the progress of Islamic education in Indonesia. Employing a descriptive qualitative approach with a desk research method, the study analyzes the phenomenon through extensive literature, including academic articles, books, and reports. The findings reveal that Islamic education in Indonesia confronts the repercussions of a post-conservative era characterized by the ascendancy of conservative religious interpretations altering the political landscape and education system dynamics. Key challenges include resource constraints, inadequate government attention, and the proliferation of conservative ideologies that marginalize local religious authorities. The repercussions include diminished educational quality, widespread teacher moonlighting, and obstacles to integrating Islamic values into the national education framework. Incidents of sexual violence within Islamic educational settings have further damaged institutional reputations. Nonetheless, Islamic education holds significant promise as a solution for character development in Indonesia through a holistic approach that engages schools, families, and communities. Adequate governmental and societal backing is imperative, involving sufficient resource allocation and policies conducive to innovation in Islamic education. By fostering synergy among schools, families, and communities and embracing a flexible, forward-thinking approach, this initiative aims to cultivate a generation strong in faith, morals, and proficient across various scientific and technological domains, poised to confront global challenges and position Indonesia as a cultured, highly competitive nation on the worldwide stage.
A Descriptive Analysis of Team-Teaching Method Application for Young Learners in Integrated Islamic Elementary School
Authors: Hafni Astrida , Ningrum Diah Widya
Published: February 2025

This descriptive analysis explores the application of the team-teaching method for young learners, focusing on a case study at an elementary school in North Sumatra, Indonesia. The study investigates the planning, implementation, evaluation, and obstacles of team teaching in fourth-grade classrooms. Qualitative data was gathered through observations, interviews, and documentation. Findings reveal collaborative lesson planning between core and assistant teachers, with a clear division of roles. Implementation involves whole team participation, with one teacher delivering material while the other assists and supervises students. Evaluation encompasses teacher feedback and student assessment, utilizing summative and formative methods. Obstacles include uneven attention distribution and student dependency on assistant teachers, with proposed solutions such as class restructuring and fostering student independence. Recommendations include continuous teacher development, principal oversight, and student engagement in the learning process. Overall, the study underscores the importance of collaborative teaching methods for enhancing student learning outcomes and addressing challenges in the educational environment.
Mitochondrial Dysfunction in Osteosarcoma Patients
Authors:   Hirao Cardiovascular Clinic, Chiba, Japan, Daigo Hirao , Maqbool Adil ,   Health and Disease Research Center (HDRCRP), Bogra, Bangladesh, Sugasawa Takehito ,   Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, Shaharul Islam AKM ,   TMSS Medical College and Hospital in Bogra, Bangladesh, Arifur Rahman ,   Health and Disease Research Center (HDRCRP), Bogra, Bangladesh, Farzana Sohael ,   Health and Disease Research Center (HDRCRP), Bogra, Bangladesh, Mowa Chishimba Nathan ,   Health and Disease Research Center (HDRCRP), Bogra, Bangladesh, Shimojo Nobutake ,   Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, Jesmin Subrina ,   Hirao Cardiovascular Clinic, Chiba, Japan,   Faculty of Medicine, University of Tsukuba, Tsukuba, Japan,   Health and Disease Research Center (HDRCRP), Bogra, Bangladesh Correspondence
Published: February 2025

This review aims to explore the relationship between mitochondrial dysfunction and osteosarcoma
progression. Osteosarcoma, a highly malignant primary bone tumor, has long been linked to various
metabolic alterations, including mitochondrial anomalies. Mitochondria, known for their roles
in energy production, reactive oxygen species regulation, and apoptosis, are implicated in cancer
pathogenesis. This paper consolidates evidence from multiple studies, highlighting how mitochondrial
dysfunction contributes to osteosarcoma development, tumor growth, and metastasis. Findings suggest
that abnormal mitochondrial functions—ranging from disrupted energy metabolism to metabolic
reprogramming—significantly impact tumor progression. Despite these insights, challenges persist in
establishing a direct causal relationship. The review identifies potential therapeutic strategies targeting
mitochondrial pathways and emphasizes the need for further studies to clarify mechanisms linking
mitochondrial dysfunction and osteosarcoma
Síndrome da Imunodeficiência Combinada Grave, uma condição grave e potencialmente fatal - Um relato de caso
Authors: Bravo Marcela Carvalho Camargo Caciatori , Cordera Ana Carolina
Published: February 2025

Introdução: A imunodeficiência grave combinada (SCID) é uma patologia caracterizada por comprometimento importante da resposta imune envolvendo linfócito T e ou B e ou células NK o que implica em aumento da suscetibilidade a infecções e altas taxas de mortalidade. Crianças com SCID são saudáveis ao nascer, as complicações infecciosas surgem no primeiro ano de vida sendo potencialmente fatais até os dois anos. O diagnóstico precoce é fundamental para o sucesso do tratamento pois crianças sem infecção tem maior condições clínicas e sobrevida após a realização do transplante de células-tronco hematopoiéticas (TCTH). Objetivos: Relatar o caso clínico de paciente com diagnóstico tardio de síndrome de imunodeficiência combinada grave assim como suas complicações e desafios para instituição do tratamento adequado. Métodos: Os dados serão obtidos através do prontuário médico eletrônico e de papel. O estudo será iniciado após o preenchimento do TCLE pela responsável legal da paciente, seguida da aprovação pelo Comitê de Ética em Pesquisa. Trata-se de um estudo do tipo observacional e descritivo, sem grupo controle, em formato de relato de caso clínico. Desfecho primário/Conclusão: Sua relevância científica está em demonstrar o quanto o atraso no diagnóstico e a falta de implementação de triagens neonatais de rotina para essas patologias congênitas graves implicam em alta mortalidade e danos irreversíveis.
Terapia com laser de baixa potência estimula a reparação tecidual da articulação temporomandibular de ratos obesos e submetidos a movimentação ortodôntica
Authors: Amorim João Paulo de Arruda , Spenassatto Janaina Ahmann , Zibetti Isabela , Silva Andyara Sepulveda Lobato da
Published: February 2025

O objetivo do presente estudo foi avaliar os efeitos da terapia com laser de baixa potência sobre as alterações histológicas na articulação temporomandibular causadas pela movimentação dentaria induzida em ratos obesos. Foram utilizados quarenta filhotes machos de ratos Wistar, trinta filhotes receberam durante os cinco primeiros dias de vida injeções subcutâneas na região cervical de 4g/Kg/dia de glutamato monossódico (animais obesos - MSG) e dez receberam injeções de solução salina hiperosmótica, 1,25g/Kg/dia (animais controles - CTL). Foram formados quatro grupos experimentais (n=10/grupo): Grupo 1: Controle (CTL), ratos que não foram submetidos a nenhum procedimento experimental; Grupo 2: ratos obesos sem movimentação dentária induzida (MSG); Grupo 3: ratos obesos que foram submetidos a movimentação dentária induzida (MDI) (MSG + MDI); Grupo 4: ratos obesos que foram submetidos a MDI e submetidos a TLBP (MSG + MDI+ TLBP). Aos 90 dias foi instalado o dispositivo de movimentação dentária induzida (MDI) nos grupos 3 e 4. Aos 91 dias foi iniciado o tratamento com o laser de baixa potência. Aos 97 dias de experimento, os animais foram pesados, medidos e sacrificados. As articulações temporomandibulares (ATM) do lado direito foram retiradas, fixadas e processadas para histologia. Os animais do grupo obeso e tratados com terapia de laser de baixa potência (MSG+MDI+TLBP) apresentaram redução da espessura do disco articular e da hiperplasia e vascularização da membrana sinovial da ATM. Concluímos que terapia com laser de baixa potência é eficaz no tratamento das alterações histológicas da ATM causadas pela movimentação ortodôntica em ratos com obesidade hipotalâmica.
A eficácia da prática do método Pilates em gestantes
Authors: Santos Jessica Souza , Reis Luana Araújo dos
Published: February 2025

Introdução: A prática de exercícios físicos durante a gestação é recomendada por organizações de saúde como a OMS, sendo o Pilates uma modalidade com crescente destaque. Objetivo: Este artigo revisa a literatura sobre a eficácia do método Pilates em gestantes, focando em seus benefícios musculoesqueléticos, controle respiratório e aspectos emocionais. Materiais e Métodos: A metodologia consistiu em uma revisão não sistemática de artigos publicados entre 2010 e 2021, selecionados em bases como Google Acadêmico e SciELO, utilizando descritores relacionados a fisioterapia, Pilates e gestação. Resultados: Os resultados indicam que o Pilates contribui para o fortalecimento dos músculos do core, aliviando dores lombares e melhorando a flexibilidade e o equilíbrio. Além disso, o controle respiratório durante os exercícios auxilia no relaxamento e preparação para o parto, enquanto os benefícios psicológicos incluem a redução da ansiedade e do estresse. A prática também melhora a qualidade do sono, essencial para o bem-estar geral das gestantes. Conclusão: Conclui-se que o Pilates, quando realizado com acompanhamento profissional, é uma ferramenta segura e eficaz para promover uma gestação mais saudável e confortável. Seus efeitos positivos na musculatura, controle da dor e saúde mental tornam-no uma prática recomendada no pré-natal, com benefícios que se estendem ao período pós-parto. Mais estudos são sugeridos para consolidar as evidências encontradas e explorar efeitos a longo prazo.
Association between systemic immune-inflammation index and trimethylamine N-oxide levels in peripheral blood and osteoporosis in overweight and obese patients
Authors: Li Lingling , An Jinyang , Bai Jia , Zhang Yangyang , Li Xinsai , Lv Haihong
Published: February 2025

Background

The intricate relationship between systemic immune-inflammation index (SII) and trimethylamine N-oxide (TMAO) in the peripheral blood and osteoporosis (OP) remains unclear. This study aims to investigate variations in the levels of SII and TMAO in the peripheral blood of overweight and obese patients, and examine the associations between these markers, bone mineral density (BMD), and the occurrence of osteoporotic fractures.

Methods

The study enrolled 765 patients aged ≥ 50 years with BMI ≥ 24 kg/m², dividing them into two groups based on visceral fat area (VFA): <100 cm² and ≥100 cm². A corrected regression model analyzed the association of SII, TMAO, BMD, and osteoporotic fractures incidence in patients with central obesity. Receiver operator characteristic (ROC) curves assessed the predictive ability of SII and TMAO for OP screening.

Results

Baseline data showed that patients with VFA ≥ 100 cm² had lower whole body (WB) and lumbar spine (LS) BMD, but higher SII and TMAO levels compared to those with VFA < 100 cm² (p < 0.05). Particularly in the group with VFA ≥ 100 cm2, there was an upward trend in SII and TMAO as bone mass decreased. Regression analysis found SII and TMAO negatively correlated with WB, LS, and femoral neck (FN) BMD, and positively correlated with osteoporotic fractures incidence (p < 0.05). Both were independent risk factors for OP, with combined SII and TMAO detection showing high diagnostic efficacy (sensitivity 94.7%, specificity 96.5%).

Conclusion

In overweight and obese patients, particularly those with a VFA ≥ 100 cm², peripheral blood SII and TMAO levels may serve as valuable biomarkers for the early diagnosis of OP, offering potential clinical utility in identifying high-risk individuals.
Marine actinomycetes: a hidden treasure trove for antibacterial discovery
Authors: Pan Chengqian , Hassan Syed Shams ul , Ishaq Muhammad , Yan Shikai , Jin Huizi
Published: February 2025

Oceans boast a substantial microbial diversity, which is widely prevalent in seawater, marine sediments, and marine organisms. In contrast to terrestrial resources explored in traditional natural product research, the habitats of marine microorganisms are distinctly unique. Actinomycetes serve as a vital source of secondary metabolites, including antibiotics and other potent natural products like streptomycin and tetracycline. They have played a pivotal role in clinical treatments for significant diseases such as pathogenic bacterial infections. Nevertheless, the extensive use of antibiotics has led to a sharp increase in the variety and number of drug-resistant bacteria, notably multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria, in clinical settings, posing a grave threat to human survival. Consequently, there is an immediate need to discover structurally novel antibacterial natural products and develop new antibiotics. This mini review summarizes a total of 45 novel antibacterial natural products derived from marine actinomycetes, published in 2024. These products, including polyketides, alkaloids, macrolactams, and peptides, are highlighted in terms of their structures and biological activities. The objective of this article is to provide valuable insights for the research and development of novel antibiotics.
The trends and future projections of intraocular foreign bodies among children and adolescents: a global analysis
Authors: Lu Zupeng , Xing Xindan , Li Wen , Qiao Tong
Published: February 2025

Objective

The aim was to evaluate the disease burden of intraocular foreign bodies (IOFBs) among children and adolescents globally based on the Global Burden of Disease, Injury, and Risk Factor Study 2021 (GBD 2021).

Methods

Data were extracted from the GBD 2021. The incidence and DALYs number and rate with 95% uncertainty interval (UI) and estimated annual percent change (EAPC) of IOFBs were estimated by age, sex and socio-demographic index (SDI) region. A Bayesian age-period-cohort (BAPC) analysis model was used to predict trends in the next ten years.

Results

Globally, it is estimated that the incidence number of IOFBs among children and adolescents increased from 5842769.65 in 1990 to 6154651.76 in 2021, while the age-specific incidence rate decreased from 258.69 in 1990 to 233.50 in 2021, with a EAPC being −0.54. The 15–19 years group had the highest incidence and DALYs number, while 0–4 years group had the lowest. The projective model indicates that the burden for IOFBs will rise sharply in the next ten years.

Conclusion

The global incidence and disease burden of blindness and vision loss in children and adolescents due to IOFB have shown a slight decline from 1990 to 2021. However, there may be a significant upward trend in the future, which requires the vigilant attention of policymakers.
Evaluation of three fish-derived probiotic bacteria replacing antibiotics on growth, immunity, gut morphology and disease resistance in juvenile olive flounder Paralichthys olivaceus fed reduced fish meal diets
Authors: Choi Wonsuk , Moniruzzaman Mohammad , Lee Seunghan , Bae Jinho , Bai Sungchul C. , Min Taesun , Lee Seunghyung
Published: February 2025

A basal diet without feed additives was used as a control (CON) and three diets were formulated by supplementing with Bacillus subtilis WB60 at 1 × 108 CFU/g (Pro-A), B. subtilis SJ10 at 1 × 108 CFU/g (Pro-B), Enterococcus faecium SH30 at 1 × 107 CFU/g (Pro-C), and two other diets supplementing with antibiotics such as amoxicillin (AMO) at 4 g/kg and oxytetracycline (OTC) at 4 g/kg of the basal diet. A total of 450 fish averaging 12.1 ± 0.09 g (mean ± SD) were fed one of the six experimental diet groups in triplicates for 8 weeks. In disease resistance test, 45 fish from each group were intraperitoneally injected with the pathogenic bacteria, Edwardsiella tarda, and mortality was recorded for 15 days. At the end of 8-week feeding trial, weight gain, specific growth rate and feed efficiency of fish fed the Pro-A diet were significantly greater than those of fish fed the CON, OTC and AMO diets (p < 0.05). Furthermore, feeding efficiency and protein efficiency ratio of fish fed the Pro-A diet were significantly greater than those of fish fed the CON, OTC and AMO diets. Serum aspartate aminotransferase levels were significantly greater in fish fed the Pro-B diet than in those fed the Pro-A diet. The lysozyme activity of fish fed the Pro-A, Pro-B and Pro-C diets was significantly greater than that of the CON, OTC and AMO diets. The myeloperoxidase activity of fish fed the Pro-A diet was significantly greater than that of the fish fed the CON and AMO diets. The flounder growth hormone levels of fish fed the Pro-A, Pro-B, Pro-C and AMO diets were significantly greater than that of the fish fed the CON diet. The interleukin 1β gene expression levels in fish fed the Pro-B and Pro-C diets were significantly greater than those in fish fed the CON, OTC and AMO diets. The interleukin 10 gene expression levels in fish fed the Pro-A, Pro-B, Pro-C and OTC diets were significantly greater than those of fish fed the CON and AMO diets. Intestinal histology revealed that the average villi length of fish fed the Pro-A, Pro-B, and Pro-C diets were significantly greater than that of fish fed the CON, OTC and AMO diets. The cumulative survival rates of fish fed the Pro-A, Pro-B and Pro-C diets were significantly greater than those of fish fed the CON diet after the 15th day of the challenge test. Overall, the results demonstrated that the supplementation of fish-derived bacteria, B. subtilis (1 × 108 CFU/g diet) or E. faecium (1 × 107 CFU/g diet) in the diet could be the ideal probiotics to replace antibiotics in olive flounder fed FM reduced diet.
TUBGCP2 variants cause lissencephaly spectrum disorders: a case report and literature review
Authors: Yu Tao , Yu Miao , Liu Xueyan , Wang Hua
Published: February 2025

Background

TUBGCP2 variants are associated with the LIS spectrum disorders, but its pathogenesis remains unclear. To retrospectively analyze the clinical features and genetic information of patients having lissencephaly spectrum disorders associated with TUBGCP2 variants.

Methods

Clinical and genetic data of a patient diagnosed with TUBGCP2-related lissencephaly spectrum disorder at the Department of Pediatric Neurology, Shengjing Hospital, in March 2022 were collected. Furthermore, we reviewed previously reported literature on patients with the same gene variation.

Results

A 6-year-old female patient presented with microcephaly (head circumference: 46 cm, Z score: <−3), narrow forehead, thick eyebrows, bulbous nose, smooth philtrum, widened and separated teeth, speech and motor developmental delay, intellectual disability, and seizures. Brain magnetic resonance imaging showed pachygyria in the temporal, parietal, and occipital lobes. Gene testing identified hemizygous variation in TUBGCP2 (missense variants: c.178 C>T, c.538T>C, and maternal exon variant: 2–14 deletion). A literature search revealed seven patients with lissencephaly spectrum disorders associated with TUBGCP2 variants, including eight gene variation types. Moreover, the TUBGCP2 variants were found to cause lissencephaly spectrum diseases, with the main clinical manifestations being microcephaly, lissencephaly (including agyria, pachygyria, or subcortical band heterotopia), dysmorphic facial features (e.g., narrow forehead, thick eyebrows, bulbous nose, prominent ears, and widened and separated teeth), and developmental delay, with or without seizures.

Conclusion

Our study expands the genotype of this brain malformation disorder associated with TUBGCP2 variants by presenting the first case of TUBGCP2 variants causing lissencephaly spectrum disorders in China.
Supporting youths in global crises: an analysis of risk and resources factors for multiple health complaints in children and adolescents during the COVID-19 pandemic
Authors: Habermann Karoline , Napp Ann-Kathrin , Reiß Franziska , Kaman Anne , Erhart Michael , Ravens-Sieberer Ulrike
Published: February 2025

Introduction

The number of global crises increased in recent years, significantly affecting the health and well-being of children and adolescents worldwide. Awareness of these global crises and their impact on health and well-being has risen since the COVID-19 pandemic. Research indicates that some children and adolescents are more vulnerable to the challenges resulting from these crises than others. This study examines the risk and resources factors for multiple health complaints (MHC) in children and adolescents in Germany during the COVID-19 pandemic.

Methods

We analyzed data from the German population-based longitudinal COPSY (COvid-19 and PSYchological Health) study. A total of 1,673 children and adolescents aged 11 years and older and their parents participated in at least one of the five survey waves between 2020 and 2022. We assessed MHC using the international Health Behavior in School-aged Children Symptom Checklist (HBSC-SCL), which includes four somatic complaints (e.g., headache, abdominal pain) and four psychological complaints (e.g., feeling low, sleeping difficulties). We conducted a mixed model panel regression analysis to examine longitudinal changes in MHC and identified sociodemographic, psychosocial, and pandemic-related risk factors and resources.

Results

Our results revealed increased MHC throughout the COVID-19 pandemic. Girls, single-parent children and adolescents, as well as children and adolescents of mentally ill or highly burdened parents, were at particular risk. A higher subjective perceived burden of the pandemic and COVID-19-related worries were significantly associated with a higher level of MHC. Personal resources, a positive family climate, and more perceived social support were significantly associated with a lower level of MHC.

Discussion

This paper highlights the vulnerability of children and adolescents in a global crisis, such as the COVID-19 pandemic. The results provide a scientific foundation for targeted health promotion and intervention strategies to protect and maintain the health and well-being of young people in future crises.
The mediating role of life satisfaction in the relationship between physical exercise and depressive symptoms among middle-aged and elderly individuals
Authors: Yang Ting , Li Xinxin , Wang Xinyu , Zhou Jingjie , Chen Wei
Published: February 2025

Objective

To investigate the mediating effect of life satisfaction between physical exercise behavior and depressive symptoms among middle-aged and elderly individuals, providing a reference for improving depressive conditions in this demographic group.

Methods

Data from 11,101 middle-aged and elderly individuals from the 2020 China Family Panel Studies (CFPS) were collected. STATA 17.0 was used for data cleaning, organization, and statistical analysis which includes univariate analysis, stepwise regression analysis, and mediation effect testing.

Results

Among 11,101 individuals aged 45 years and above, 2,272 participated in physical exercise, accounting for 20.47%; 2,052 exhibited depressive symptoms, representing 18.48%. Physical exercise was positively correlated with life satisfaction and negatively correlated with depression. Depression scores also showed a negative correlation with life satisfaction. According to the results of the mediation effect study, life satisfaction accounted for 16.60% of the overall effect and had a mediating effect value of −0.099 on depression symptoms.

Conclusion

Physical exercise and life satisfaction are factors influencing depressive symptoms, and life satisfaction acts as a partial mediator between physical exercise participation and depression among middle-aged and elderly adults.
Influence of meteorological and environmental factors on pediatric urinary tract infections: insights from a 6-year retrospective study in Central China
Authors: Li Changzhen , Tang Feng , Xi Lei , Wang Xiaomei
Published: February 2025

Objectives

To investigate the association between meteorological factors and common uropathogens in children with urinary tract infections (UTIs) and assesses the potential influence of weather conditions on pediatric UTIs.

Study design

Analyze the demographic and uropathogen characteristics from children with culture-proven UTIs and its correlation with meteorological factors.

Methods

2,411 data from infants and children with UTIs in a children’s hospital from 2016 to 2021 were retrospectively analyzed. A correlation analysis was conducted to investigate the relationship between the monthly detection number of uropathogens and meteorological factors.

Results

Multiple linear stepwise regression analyses showed a positive correlation between monthly average temperature, precipitation volume, sunshine hours, monthly total number of uropathogens, and the number of E. coli and E. faecalis. E. faecium was predominant in <12-month-old children, while E. coli was dominant in the 3–18-year age category. E. faecium showed a higher prevalence in girls, while E. faecalis was more prevalent in boys. E. coli exhibited resistance rates of >40% to second-or third-generation cephalosporins in multiple age groups. E. faecium showed high resistance rates to tetracyclines, fluoroquinolones, erythromycin, ampicillin, and penicillin, while K. pneumoniae displayed higher sensitivity to cephalosporin–sulbactam and amikacin, but higher resistance rates to cefazolin and ceftazidime.

Conclusion

This study reveals the association between meteorological factors and uropathogens in children with UTIs, as well as the distribution, age-related characteristics, gender differences and antibiotic resistance profiles of pathogenic bacteria. These findings inform the development of targeted strategies for UTI prevention and treatment based on uropathogenic characteristics and meteorological conditions.