bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlates of Physical Activity of Children and Adolescents with Autism Spectrum Disorder in Low- and Middle-Income Countries: A Systematic Review of Cross-Sectional Studies
Authors: Zhong Tianwei , Liu Hui , Li Yan , Qi Jing
Published: December 2022

Children and adolescents with autism spectrum disorder (ASD) are at a high risk for a lack of physical activity (PA). The aim of this study is to review the evidence on the correlates of PA in children and adolescents with ASD in low- and middle-income countries. We searched Psychology and Behavioral Sciences Collection (PBSC), Scopus, PsycINFO, Web of Science (WOS), MEDLINE, Education Resources Information Center (ERIC), Education Source (ES), and Academic Search Premier (ASP) databases for relevant studies until April 2022, inclusive, to examine the factors associated with the studies of PA in children and adolescents with ASD aged 5 to 17 years in low- and middle-income countries. A total of 15 articles are included in the present review. Three researchers assessed the methodological quality and extracted relevant data of the included reviews. The correlates were synthesized and further assessed semi-quantitatively. Results of this review show that gender (boys) and more PA opportunities were positively associated with the PA of children and adolescents with ASD, while age and body mass index (BMI) were negatively related to their PA levels in low- and middle-income countries. The day of week was found to be inconsistently associated with PA in children and adolescents with ASD. The findings suggest that research on the correlates of PA in adolescents with ASD in low- and middle-income countries is limited. However, there are clear correlates for which future interventions could be based (age, gender, BMI, and PA opportunity) to promote PA participation in children and adolescents with ASD in low- and middle-income countries.
Exploring the Mechanism of the Impact of Green Finance and Digital Economy on China’s Green Total Factor Productivity
Authors: Guo Jianfeng , Zhang Kai , Liu Kecheng
Published: December 2022

In the context of the “double cycle,” promoting the development of a green economy is an important goal for China’s high-quality economic development in the digital age. This paper uses data from 30 provinces (municipalities and autonomous regions) in China during the 2006–2019 period using the Compiled Green Finance Index (GF) and Digital Economy Index (DE). The interrelationship between green finance, digital economy and green total factor productivity (GTFP) is empirically tested by conducting multiple regressions on panel data from 2006–2019 to perform an empirical analysis. Based on this, further analysis was performed with the threshold model. This study found that green finance and digital economy can contribute well to green total factor productivity, but the combination of the two does not have a good effect on green total factor productivity. Further study found that the green finance and digital economy’s contribution to green total factor productivity is mainly derived from technological progress. The regression results based on the panel threshold model show that the more underdeveloped the digital economy is in certain regions, the stronger the role of green finance in promoting efficiency improvement. Therefore, policymakers should formulate differentiated green financial policies according to the level of development of the digital economy and give play to the role of green finance and the digital economy in promoting green total factor productivity.
Caregiver Burden, Psychological Distress and Quality of Life among Informal Caregivers of Patients with Head and Neck Cancer: A Longitudinal Study
Authors: Van Hof Kira S. , Hoesseini Arta , Dorr Maarten C. , Verdonck-de Leeuw Irma M. , Jansen Femke , Leemans C. René , Takes Robert P. , Terhaard Chris H. J. , Baatenburg de Jong Robert Jan , Sewnaik Aniel , Offerman Marinella P. J.
Published: December 2022

(1) Background: The aim of this study was to investigate caregiver burden among informal caregivers of head and neck cancer patients, in relation to distress and quality of life (QoL), and the relationship between informal caregivers and patients. (2) Methods: Data of 234 dyads from the multicenter prospective cohort study Netherlands Quality of life and Biomedical Cohort studies in cancer was used. Caregiver burden, psychological distress, global QoL, physical and social functioning were measured from baseline until 24 months after treatment. (4) Conclusions: This prospective cohort study shows the high burden of caring for HNC patients, the impact of this burden and the interaction between caregiver and patient. We suggest that healthcare professionals include caregivers in counseling and support.
Asbestos Exposure and Severity of COVID-19
Authors: Granados Galo , Sáez-López María , Aljama Cristina , Sampol Júlia , Cruz María-Jesús , Ferrer Jaume ,   Se-COVID-19 Team
Published: December 2022

Background: The aim of this study was to analyse the relationship between occupational exposure to asbestos and the severity of SARS-CoV-2 infection. Methods: We evaluated patients who survived admission in our centre for COVID-19 pneumonia. Demographic, analytical, and clinical variables were collected during admission. After discharge, a previously validated occupational exposure to asbestos questionnaire was administered. Spirometry, CO diffusion test, the 6-min walk test, and high-resolution chest CT were performed. Patients who required respiratory support (oxygen, CPAP, or NIV) were considered severe. Results: In total, 293 patients (mean age 54 + 13 years) were included. Occupational exposure to asbestos was detected in 67 (24%). Patients with occupational exposure to asbestos had a higher frequency of COVID-19 pneumonia requiring respiratory support (n = 52, 77.6%) than their unexposed peers (n = 139, 61.5%) (p = 0.015). Asbestos exposure was associated with COVID-19 severity in the univariate but not in the multivariate analysis. No differences were found regarding follow-up variables including spirometry and the DLCO diffusion, the 6-min walk test, and CT alterations. Conclusions: In hospitalised patients with COVID-19 pneumonia, those with occupational exposure to asbestos more frequently needed respiratory support. However, an independent association between asbestos exposure and COVID-19 severity could not be confirmed.
Smart Helmet-Based Proximity Warning System to Improve Occupational Safety on the Road Using Image Sensor and Artificial Intelligence
Authors: Kim Yeanjae , Choi Yosoon
Published: December 2022

Recently, collisions between equipment and workers occur frequently on the road in construction and surface mining sites. To prevent such accidents, we developed a smart helmet-based proximity warning system (PWS) that facilitates visual and tactile proximity warnings. In this system, a smart helmet comprising an Arduino Uno board and a camera module with built-in Wi-Fi was used to transmit images captured by the camera to a smartphone via Wi-Fi. When the image was analyzed through object detection and a heavy-duty truck or other vehicle was detected in an image, the smartphone transmitted a signal to the Arduino via Bluetooth and, when a signal was received, an LED strip with a three-color LED visually alerted the worker and the equipment operator. The performance of the system tested the recognition distance of the helmet according to the pixel size of the detected image in an outdoor environment. The proposed personal PWS can directly produce visual proximity warnings to both workers and operators enabling them to quickly identify and evacuate from dangerous situations.
The Effect of 13 Weeks Long-Distance Bicycle Riding on Inflammatory Response Indicators Related to Joint Cartilage and Muscle Damage
Authors: Kim Hyung-Jun , Lee Hyo-Cheol
Published: December 2022

This study was to investigate the effects of 13 weeks of long-distance cycling on biomarkers of joint cartilage, muscle damage and inflammation. All subjects in this study were seven participants of the “One Korea New-Eurasia Peace Cycle Expedition”, in which they rode cycles from Berlin, Germany to Seoul, Korea for thirteen weeks. The total course of the expedition was divided into three sub-courses: course 1 (from Berlin to Moscow), course 2 (from Moscow to Ulaanbaatar) and course 3 (from Ulaanbaatar to Seoul). All the selected participants rode 87.4 km/day (course 1), 70.4 km/day (course 2) and 57.6 km/day (course 3) on average, respectively. We collected their blood samples before the expedition in Seoul (S1), after course 1 in Moscow (M), after course 2 in Ulaanbaatar (U) and after the expedition in Seoul (S2), to analyze biomarkers of joint cartilage damage (Cartilage Oligomeric Matrix Protein; COMP), muscle damage (Creatine Phosphokinase; CPK, Lactate Dehydrogenase; LDH, Myoglobin), inflammation (Interleukin-6; IL-6, Interleukin-1β; IL-1β, Tumor Necrosis Factor-α; TNF-α, C-Reactive Protein; CRP) and stress hormone (Cortisol). According to this result, COMP (S1; 188.37 ± 46.68 ng/mL) showed a significant increase after the expedition course 1 (M; 246.69 ± 51.69 ng/mL, p = 0.012) and course 2 (U; 237.09 ± 62.57 ng/mL, p = 0.047), and recovered to the stable state after expedition course 3 (S2; 218.46 ± 34.78. p = 0.047). Biomarkers of muscle damage (CPK, LDH and Myoglobin) and inflammation (IL-6, IL-1β, TNF-α and CRP) were not significantly changed in all courses, but CRP (S1; 1.07 ± 0.76 ng/mL) showed a tendency to decrease after the expedition course 1 (M; 0.3 ± 0.1 mg/mL, p = 0.044). Lastly, the Cortisol level significantly increased in all courses (per p < 0.05), but the Cortisol level after expedition course 3 (S2; 21.00 ± 3.65 mg/mL) was lower than that of after the expedition course 1 (M; 24.23 ± 2.47 mg/mL, p = 0.028). In summary, it seems that repetitive and continuous 50–90 km/day of cycling can increase joint cartilage damage risk and stress hormone temporarily. However, this result suggests that the appropriate intensity of cycling for thirteen weeks does not increase physical damage, and rather enhances the human body to adapt to exercise training.
Use of the Internet for Health Purposes—A National Web-Based Cross-Sectional Survey among Adults in Poland
Authors: Płaciszewski Krzysztof , Wierzba Waldemar , Ostrowski Janusz , Pinkas Jarosław , Jankowski Mateusz
Published: December 2022

The Internet is one of the most popular information sources. This study aimed to assess the public attitudes towards the use of the Internet for health purposes as well as to identify factors associated with the use of the Internet for health purposes among adults in Poland. A web-based cross-sectional survey was carried out between 9 and 12 September 2022 on a nationwide random-quota sample of 1092 adults in Poland. The study questionnaire included 10 questions on Internet use for health purposes. The most common reason for the use of the Internet for health purposes was searching for information on drugs and their effects (69.9%). Almost two-thirds of participants used the Internet for searching for health information (64.9%), for doctors/medical services (63.4%), or for medical facilities (65.3%). Over half of the participants used the Internet for checking online reviews of doctors (55.2%) and 43.5% of the participants ordered drugs or dietary supplements online. Out of 9 different socioeconomic factors analyzed in this study, having higher education, being female, as well as living in cities from 100,000 to 499,999 residents were the most important factors (p < 0.05) associated with the use of the Internet for health purposes. This study confirmed a high level of adoption of medical Internet in Poland.
Study of Township Construction Land Carrying Capacity and Spatial Pattern Matching in Loess Plateau Hilly and Gully Region: A Case of Xifeng in China
Authors: Zhao Yirui , Li Tongsheng , Li Julin , Song Mengwei
Published: December 2022

With the acceleration of urbanization, the construction land scale of urban and rural areas is constantly expanding, which leads to contradiction and conflict between territorial development and ecological protection becoming more and more serious. Therefore, as an important unit of county (district), and even urban and rural, development, the study on land resource carrying capacity and the rationality of the development can provide some basis for developing the optimal strategies of differential territorial space. Taking Xifeng, Gansu Province, China as the research area, this study constructs the evaluation index system of township construction land carrying capacity from the three dimensions of ecological protection, natural environment, and social economy. It evaluates the suitability of township construction land by the means of a comprehensive scoring method and discusses the carrying capacity and spatial pattern matching of township construction land based on the suitability evaluation results. The results showed that: (1) the spatial difference of suitability of construction land is obvious, which is higher in the city center than in the surrounding areas; (2) the comprehensive carrying capacity of township construction land is 52.62%, and different townships range from 3.78% to 13.15%. It is different between towns; (3) on the whole, the condition of township construction land is well-developed, and the main distribution forms are flaky, banded, and dotted. (4) There is a positive correlation between spatial matching and carrying capacity. The carrying capacity should be considered in regional development to avoid overdevelopment. It can provide a basis for optimizing the territorial spatial layout, strengthening the coordinated development among townships, and improving the comprehensive township carrying capacity in the Loess Plateau hilly and gully region.
Associations of the Short Physical Performance Battery (SPPB) with Adverse Health Outcomes in Older Adults: A 14-Year Follow-Up from the English Longitudinal Study of Ageing (ELSA)
Authors: Western Max J. , Malkowski Olivia S.
Published: December 2022

The Short Physical Performance Battery (SPPB) is an objective tool for evaluating three domains (balance, repeated chair stands, and gait speed) of lower extremity physical function in older age. It is unclear how the associations between SPPB scores and health outcomes persist over time. The aim of this 14-year cohort study was to investigate associations between SPPB scores and health outcomes among participants aged 60+ years in the English Longitudinal Study of Ageing (ELSA). The exposures were SPPB scores (total and domain-specific) at baseline (Wave 2). The outcomes were mobility impairments, difficulties in performing basic activities of daily living (ADL) or instrumental activities of daily living (IADL), and falls, measured at seven subsequent timepoints (Waves 3 to 9). The analyses involved linear and logistic multilevel regressions. After adjusting for potential confounders, a one-point increase in the total SPPB score was associated with a 0.13 (95% CI: −0.16, −0.10) decrease in mobility impairment, a 0.06 (−0.08, −0.05) decrease in ADL disabilities, a 0.06 (−0.07, −0.04) decrease in IADL disabilities, and 8% (0.90, 0.95) lower odds of falling (averaged across all follow-ups). Associations between the SPPB domains and health outcomes were more varied. The SPPB may be a useful measure for identifying older adults at a high risk of adverse outcomes.
Burnout Syndrome and COVID-19 Lockdown: Research on Residential Care Workers Who Assume Parental Roles with Youths
Authors: Ferro Laura , Cariello Marina , Colombesi Alessandra , Segantini Alberto , Centonze Eleonora , Baccini Giorgia , Cristofanelli Stefania
Published: December 2022

Healthcare professionals are at higher risk of developing and experiencing burnout. Parents may also suffer from prolonged stressful conditions that lead to physical and emotional exhaustion. Residential youth care workers assume a caregiving role that can lead to persistent stressful conditions that affect their relationship with the youth. In addition, the COVID-19 lockdown has had a negative impact on both the organization and the work, as well as on the lifestyle of workers and minors. In fact, during the pandemic, contact with families was not possible due to restrictions and this increased the need for caregivers to assume a parental role. This research aims to examine the risk of burnout in a sample of 75 healthcare professionals working with youths and the association with psychological traits. Then, we aim to evaluate these aspects during the COVID-19 lockdown The measurements, conducted in both February 2019 and April 2021, included six questionnaires: MBI to assess burnout, TAS_20 to explore alexithymic traits, COPE_NVI to assess coping strategies, FDS_R to quantify frustration intolerance at work, IRI for empathy, and FFMQ to investigate awareness and emotional regulation. Our sample shows a medium-high risk of developing burnout, which worsened during the pandemic. A worsening of emotional skills, paralleled by a greater empathic investment required by the emergency situation, and an assumed parental role is observable. Coping strategies correlate with burnout risk, as avoidance strategies were strongly associated with emotional exhaustion. These findings suggest an urgent need to develop targeted and timely interventions for healthcare professionals in order to prevent long-term consequences.
Resistance Training Improves Sleep and Anti-Inflammatory Parameters in Sarcopenic Older Adults: A Randomized Controlled Trial
Authors: de Sá Souza Helton , de Melo Camila Maria , Piovezan Ronaldo Delmonte , Miranda Rafael Eduardo Eustórgio Pinheiro Chagas , Carneiro-Junior Miguel Araujo , Silva Bruno Moreira , Thomatieli-Santos Ronaldo Vagner , Tufik Sergio , Poyares Dalva , D’Almeida Vânia
Published: December 2022

Sleep and exercise have an important role in the development of several inflammation-related diseases, including sarcopenia. Objective: To investigate the effects of 12 weeks of resistance exercise training on sleep and inflammatory status in sarcopenic patients. Methods: A randomized controlled trial comparing resistance exercise training (RET) with a control (CTL) was conducted. Outcomes were obtained by physical tests, polysomnography, questionnaires, isokinetic/isometric dynamometry tests, and biochemical analysis. Results: Time to sleep onset (sleep latency) was reduced in the RET group compared to the CTL group (16.09 ± 15.21 vs. 29.98 ± 16.09 min; p = 0.04) after the intervention. The percentage of slow-wave sleep (N3 sleep) was increased in the RET group (0.70%, CI: 7.27–16.16 vs. −4.90%, CI: 7.06–16.70; p = 0.04) in an intention to treat analysis. Apnea/hour was reduced in the RET group (16.82 ± 14.11 vs. 7.37 ± 7.55; p = 0.001) and subjective sleep quality was improved compared to the CTL (−1.50; CI: 2.76–6.14 vs. 0.00; CI: 1.67–3.84 p = 0.02) in an intention-to-treat analysis. Levels of interleukin-10 (IL-10) (2.13 ± 0.80 vs. 2.51 ± 0.99; p < 0.03) and interleukin-1 receptor antagonist (IL-1ra) (0.99 ± 0.10 vs. 0.99 ± 0.10 ng/mL; p < 0.04; delta variation) were increased in the RET group. Conclusions: RET improves sleep parameters linked to muscle performance, possibly due to an increase in anti-inflammatory markers in older sarcopenic patients.
Correlation between Adrenoceptor Expression and Clinical Parameters in Degenerated Lumbar Intervertebral Discs
Authors: Brenneis Marco , Jenei-Lanzl Zsuzsa , Kupka Johannes , Braun Sebastian , Junker Marius , Zaucke Frank , Rickert Marcus , Meurer Andrea
Published: December 2022

Despite advanced knowledge of the cellular and biomechanical processes of intervertebral disc degeneration (IVDD), the trigger and underlying mechanisms remain unclear. Since the sympathetic nervous system (SNS) has been shown to exhibit catabolic effects in osteoarthritis pathogenesis, it is attractive to speculate that it also influences IVDD. Therefore, we explored the adrenoceptor (AR) expression profile in human IVDs and correlated it with clinical parameters of patients. IVD samples were collected from n = 43 patients undergoing lumbar spinal fusion surgery. AR gene expression was analyzed by semi-quantitative polymerase chain reaction. Clinical parameters as well as radiological Pfirrmann and Modic classification were collected and correlated with AR expression levels. In total human IVD homogenates α1A-, α1B-, α2A-, α2B-, α2C-, β1- and β2-AR genes were expressed. Expression of α1A- (r = 0.439), α2A- (r = 0.346) and β2-AR (r = 0.409) showed a positive and significant correlation with Pfirrmann grade. α1A-AR expression was significantly decreased in IVD tissue of patients with adjacent segment disease (p = 0.041). The results of this study indicate that a relationship between IVDD and AR expression exists. Thus, the SNS and its neurotransmitters might play a role in IVDD pathogenesis. The knowledge of differential AR expression in different etiologies could contribute to the development of new therapeutic approaches for IVDD.
Efficient Construction of Symmetrical Diaryl Sulfides via a Supported Pd Nanocatalyst-Catalyzed C-S Coupling Reaction
Authors: Jin Hao , Liu Penghao , Teng Qiaoqiao , Wang Yuxiang , Meng Qi , Qian Chao
Published: December 2022

Aryl sulfides play an important role in pharmaceuticals, biologically active molecules and polymeric materials. Herein, a general and efficient protocol for Pd@COF-TB (a kind of Pd nanocatalyst supported by a covalent organic framework)/DIPEA-catalyzed one-pot synthesis of symmetrical diaryl sulfides through a C-S coupling reaction from aryl iodides and Na2S2O3 is developed. More importantly, the addition of N,N-diisopropylethylamine (DIPEA) can not only enhance the catalytic activity of a Pd@COF-TB nanocatalyst, but also effectively inhibit the formation of biphenyl byproducts, which are a product of Ullmann reaction. Besides, it has been confirmed that the aryl Bunte salts generated in situ from Na2S2O3 and aryl iodides are the sulfur sources involved in this C-S coupling reaction. With the strategy proposed in this work, a variety of symmetrical diaryl sulfides could be obtained in moderate to excellent yields with a high tolerance of various functional groups. Moreover, a possible mechanism of this Pd nanoparticle-catalyzed C-S coupling reaction is proposed based on the results of controlling experiments.
TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by NTRK Fusions
Authors: Cappellesso Rocco , Nicolè Lorenzo , Del Fiore Paolo , Barzon Luisa , Sinigaglia Alessandro , Riccetti Silvia , Franco Renato , Zito Marino Federica , Munari Giada , Zamuner Carolina , Cavallin Francesco , Sbaraglia Marta , Galuppini Francesca , Bassetto Franco , Alaibac Mauro , Chiarion-Sileni Vanna , Piccin Luisa , Benna Clara , Fassan Matteo , Mocellin Simone , Dei Tos Angelo Paolo
Published: December 2022

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (NTRK) genes are now actionable with targeted inhibitors. NTRK-fused genes have been identified in neuroendocrine tumors of other sites; thus, a series of 76 MCCs were firstly analyzed with pan-TRK immunohistochemistry and the positive ones with real-time RT-PCR, RNA-based NGS, and FISH to detect the eventual underlying gene fusion. Despite 34 MCCs showing pan-TRK expression, NTRK fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions.
A Thiosemicarbazone Derivative as a Booster in Photodynamic Therapy—A Way to Improve the Therapeutic Effect
Authors: Gawecki Robert , Polanski Jaroslaw , Mrozek-Wilczkiewicz Anna
Published: December 2022

Photodynamic therapy is one of the most patient friendly and promising anticancer therapies. The active ingredient is irradiated protoporphyrin IX, which is produced in the body that transfers energy to the oxygen-triggering phototoxic reaction. This effect could be enhanced by using iron chelators, which inhibit the final step of heme biosynthesis, thereby increasing the protoporphyrin IX concentration. In the presented work, we studied thiosemicarbazone derivative, which is a universal enhancer of the phototoxic effect. We examined several genes that are involved in the transport of the heme substrates and heme itself. The results indicate that despite an elevated level of ABCG2, which is responsible for the PpIX efflux, its concentration in a cell is sufficient to trigger a photodynamic reaction. This effect was not observed for 5-ALA alone. The analyzed cell lines differed in the scale of the effect and a correlation with the PpIX accumulation was observed. Additionally, an increased activation of the iron transporter MFNR1 was also detected, which indicated that the regulation of iron transport is essential in PDT.
Decreasing Species Richness with Increase in Elevation and Positive Rapoport Effects of Crambidae (Lepidoptera) on Mount Taibai
Authors: Chen Anping , Li Zhijie , Zheng Yufeng , Zhan Jinyu , Yang Bolan , Yang Zhaofu
Published: December 2022

Rapoport’s rule proposes that a species’ range size increases with the increase in a gradient (such as latitude, altitude or water depth). However, altitudinal distributions and Rapoport’s rule have rarely been tested for Asian Lepidoptera. Pyraustinae and Spilomelinae (Lepidoptera: Crambidae) are extremely diverse in temperate Asia, including on Mount Taibai, which is considered a hotspot area for studying the vertical distribution patterns of insect species. Based on the investigation of altitudinal distribution data with identification by using both DNA barcoding and the morphological classification of Pyraustinae and Spilomelinae, this paper determines the altitudinal gradient pattern for these two subfamilies on the north slope of Mount Taibai, and provides a test of the universality of Rapoport’s rule in Lepidoptera by using four methods, including Stevens’ method, Pagel’s method, Rohde’s method, and the cross-species method. Our results show that the alpha diversity of Pyraustinae and Spilomelinae both decrease with rising altitude. By contrast, the species’ ranges increase with rising altitude. Three of the four methods used to test Rapoport’s rule yielded positive results, while Rohde’s results show a unimodal distribution model and do not support Rapoport’s rule. Our findings fill the research gap on the elevational diversity of Lepidoptera in temperate Asia.
Inpatient Geriatric Rehabilitation: Definitions and Appropriate Admission Criteria, as Established by Maltese National Experts
Authors: Muscat Francesca , Camilleri Liberato , Attard Conrad , Lungaro Mifsud Stephen
Published: December 2022

(1) Background: The importance of having an appropriate admissions system for geriatric rehabilitation is on the increase. However, the process of admitting patients to inpatient rehabilitation is a complex process. This is yet to be standardised across the European Union, as the approach to geriatric rehabilitation tends to vary from one Member State to another. (2) Objective: To discuss evidence-based practice with clinical experts, in order to define geriatric rehabilitation and admission criteria based on the Maltese population. (3) Method: The study entailed conducting four panel sessions using a purposive sample of thirteen local clinicians with extensive knowledge in clinical rehabilitation and healthcare management. A total of 48 items, based on the literature and clinical experience, were presented to the panel. Data analysis was done quantitatively and qualitatively, using IBM SPSS Statistics Version 24 and thematic analysis. (4) Results: The panel formulated a definition of rehabilitation, which shared common elements with the definition provided by the World Health Organization (WHO) and other sources/literature. The panel agreed on a list of eight criteria for appropriate inpatient geriatric rehabilitation admission in Malta. Consensus was also reached on: the need for a consultant-led multidisciplinary approach to assessment; the adoption of a standardised assessment processes for an equitable chance for all older adults assessed; the benefit of digital health in assessments; and the consideration that most patients would have some form of rehabilitation potential, depending on availability of resources. (5) Conclusion: Inpatient geriatric rehabilitation hospitals should have a unified strategy for rehabilitation services. The conclusions reached by the panel, could be useful in supporting the clinical evidence and establishing future rehabilitation guidelines and standards for inpatient rehabilitation.
Machine Learning Model Development and Validation for Predicting Outcome in Stage 4 Solid Cancer Patients with Septic Shock Visiting the Emergency Department: A Multi-Center, Prospective Cohort Study
Authors: Ko Byuk Sung , Jeon Sanghoon , Son Donghee , Choi Sung-Hyuk , Shin Tae Gun , Jo You Hwan , Ryoo Seung Mok , Kim Youn-Jung , Park Yoo Seok , Kwon Woon Yong , Suh Gil Joon , Lim Tae Ho , Kim Won Young
Published: December 2022

A reliable prognostic score for minimizing futile treatments in advanced cancer patients with septic shock is rare. A machine learning (ML) model to classify the risk of advanced cancer patients with septic shock is proposed and compared with the existing scoring systems. A multi-center, retrospective, observational study of the septic shock registry in patients with stage 4 cancer was divided into a training set and a test set in a 7:3 ratio. The primary outcome was 28-day mortality. The best ML model was determined using a stratified 10-fold cross-validation in the training set. A total of 897 patients were included, and the 28-day mortality was 26.4%. The best ML model in the training set was balanced random forest (BRF), with an area under the curve (AUC) of 0.821 to predict 28-day mortality. The AUC of the BRF to predict the 28-day mortality in the test set was 0.859. The AUC of the BRF was significantly higher than those of the Sequential Organ Failure Assessment score and the Acute Physiology and Chronic Health Evaluation II score (both p < 0.001). The ML model outperformed the existing scores for predicting 28-day mortality in stage 4 cancer patients with septic shock. However, further studies are needed to improve the prediction algorithm and to validate it in various countries. This model might support clinicians in real-time to adopt appropriate levels of care.
Starting Home Telemonitoring and Oxygen Therapy Directly after Emergency Department Assessment Appears to Be Safe in COVID-19 Patients
Authors: van den Berg Rosaline , Meccanici Celisa , de Graaf Netty , van Thiel Eric , Schol-Gelok Suzanne
Published: December 2022

Background: Since data on the safety and effectiveness of home telemonitoring and oxygen therapy started directly after Emergency Department (ED) assessment in COVID-19 patients are sparse but could have many advantages, we evaluated these parameters in this study. Methods: All COVID-19 patients ≥18 years eligible for receiving home telemonitoring (November 2020-February 2022, Albert Schweitzer hospital, the Netherlands) were included: patients started directly after ED assessment (ED group) or after hospital admission (admission group). Safety (number of ED reassessments and hospital readmissions) and effectiveness (number of phone calls, duration of oxygen usage and home telemonitoring) were described in both groups. Results: 278 patients were included (n = 65 ED group, n = 213 admission group). ED group: 23.8% (n = 15) was reassessed, 15.9% (n = 10) was admitted and 7.7% (n = 5) ICU admitted. Admission group: 15.8% (n = 37) was reassessed, 6.5% (n = 14) was readmitted and 2.4% (n = 5) ICU (re)admitted. Ten patients died, of whom 7 due to COVID-19 (1 in ED group; 6 in the admission group). ED group: median duration of oxygen therapy was 9 (IQR 7–13) days; the total duration of home telemonitoring was 14 (IQR 9–18) days. Admission group: duration of oxygen therapy was 10 (IQR 6–16) days; total duration of home telemonitoring was 14 (IQR 10–20) days. Conclusion: it appears to be safe to start home telemonitoring and oxygen therapy directly after ED assessment.
Healing Patterns of Non-Collagenated Bovine and Collagenated Porcine Xenografts Used for Sinus Floor Elevation: A Histological Study in Rabbits
Authors: Miyauchi Yuhei , Izutani Takayuki , Teranishi Yuki , Iida Takahisa , Nakajima Yasushi , Xavier Samuel Porfirio , Baba Shunsuke
Published: December 2022

Objective: To compare healing of collagenated and non-collagenated xenografts used for maxillary sinus floor elevation. Materials and Methods: Two different xenografts were used: deproteinized bovine bone (DBBM group) and collagenated corticocancellous porcine bone (collagenated group). Healing was studied after 2, 4, and 8 weeks. The loss of dimensions of the elevated area and the percentages of new bone, xenograft remnants, osteoclastic zones, vessels, inflammatory infiltrates, and soft tissues were analyzed. Three regions were evaluated: close to the bone walls (bone wall region), subjacent the sinus mucosa (submucosa region), and the center of the elevated area (middle region). The primary variables were the percentage of new bone and xenograft remnants. Results: Between 2 and 8 weeks, the elevated areas showed a reduction of 16.3% and 52.2% in the DBBM and collagenated groups, respectively (p < 0.01 between the two areas after 8 weeks). After 8 weeks, the highest content of new bone was observed in the bone wall region, which was higher in the collagenated group than in the DBBM group (41.6% and 28.6%, respectively; p < 0.01). A similar quantity of new bone was found between the two groups in other regions. A higher percentage of vessels in all regions evaluated (p < 0.01) and soft tissue in the sub-mucosa region (p < 0.05) was found in the collagenated group than in the DBBM group. Conclusions: The present study showed that both xenografts allowed new bone formation. In comparison with the non-collagenated xenograft, the collagenated xenograft underwent higher resorption, resulting in greater shrinkage of the elevated space after sinus lifting and a higher content of new bone in the regions close to the bone walls. Clinical relevance: In this study, the region adjacent to the bone wall showed the highest new bone content. This region resembles the base of the sinus, closest to the sinus floor and walls, and is the most important region from a clinical point of view because it is where the implant will be installed. Residues of the biomaterial remained after 8 weeks of healing. Other reports have shown that these biomaterial residues may interfere with the integration of implants.
Numerical Investigation of Vortex Shedding from a 5:1 Rectangular Cylinder at Different Angles of Attack
Authors: Wu Jian , Liu Yakun , Zhang Di , Cao Ze , Guo Zijun
Published: December 2022

Although flow around a 5:1 rectangular cylinder at small angles of attack (AoA) has been extensively studied, when the AoA becomes larger, the research is rare. Therefore, this study performs Unsteady Reynolds-Averaged Navier-Stokes simulations (URANS) using the k-ω SST turbulence model for unsteady flow around a two-dimensional 5:1 rectangular cylinder at different AoAs up to 45°. A strong dependence of the flow characteristics on AoA is observed through the analysis of the time-averaged lift coefficient, drag coefficient, and Strouhal number. The peak of lift and drag coefficient is observed to be correlated, respectively, to the leading- and trailing-edge vortex based on the analysis of the flow. The x′-directional length of the main recirculation bubble on the top side and the distance from the bubble center to the leading edge of the cylinder both reach the maximum when α = 15°. In addition, the standard deviation σx′ of the time-averaged velocity U¯x′ along the cylinder shows a trend of increasing at first and then decreasing, and that σy′ also shows the same trend at α = 20°~45°; it fluctuates within a range of 0.05~0.2 at α = 0°~20°. Finally, two principal modes of vortex shedding are observed with α = 15° being their turning point, (i) “1 + 1” mode: in one vortex shedding period, two major vortices shed off from the top and bottom sides of the cylinder at α ≤ 15°; (ii) “2 + 2” mode, four vortices shed off from the top and bottom sides of the cylinder at α > 15° in one vortex shedding period.
Dynamic Modeling of Underwater Snake Robot by Hybrid Rigid-Soft Actuation
Authors: Zhang Junhao , Chen Yinglong , Liu Yi , Gong Yongjun
Published: December 2022

For decades, underwater vehicles have been performing underwater operations, which are critical to the development and upgrading of underwater robots. With the advancement of technology, various types of robots have been developed. The underwater robotic snake is a bioinspired addition to the family of underwater robotic vehicles. In this paper, we propose an innovative underwater snake robot actuated by rigid propulsions and soft joints, which can improve the swimming efficiency and flexibility of the robot and reduce the probability of collision leading to damage. Existing math models of robotic snakes typically incorporate only planar motion, rarely considering spatial motion. So, we formulate a complete three-dimensional dynamic model for the robotic snake, which is extended by deriving expressions for the geometric Jacobians. This modeling approach is well suited since it provides compact matrix expressions and easy implementation. We use the constant curvature method to describe the configuration of the soft joint, use the Lagrangian method to obtain its dynamic characteristics, and focus on deriving the visco-hyperelastic mechanical energy of the soft material. Next, the local dynamics of soft members are extended as a nonholonomic constraint form for modeling the snake robot. Finally, the multi-modal swimming behavior of the robot has been verified by simulations, including forward and backward rectilinear motion, yaw turning, pitch motion, and spiral rising motion. The overall results demonstrate the effectiveness and the versatility of the developed dynamic model in the prediction of the robot trajectory, position, orientation, and velocity.
Lateral Export and Sources of Subsurface Dissolved Carbon and Alkalinity in Mangroves: Revising the Blue Carbon Budget
Authors: Alongi Daniel M.
Published: December 2022

Mangroves are carbon-rich ecosystems that store large quantities of carbon, mostly in soils. Early carbon (C) budgets indicated that >50% of mangrove C fixation was unaccounted for. This ‘missing C’ has now been discovered to be a large release (423 Tg C a−1) of porewater dissolved DIC (dissolved inorganic carbon), dissolved organic carbon (DOC), and total alkalinity (17 TMOL a−1) via lateral export derived from bacterial decomposition of soil organic matter. This large export originates from DIC produced over at least a 1.0–1.5 m soil profile (280–420 Tg C a−1) via decomposition of autochthonous and allochthonous inputs and/or likely mineralization in deep (≥1 m) ancient soils. DOC and DIC export from mangroves equate to 41% and ≈100% of export from the world’s tropical rivers, respectively. A newly revised blue carbon budget for the world’s mangroves indicates a mean ecosystem gross primary production (GPPE) to ecosystem respiration (RE) ratio of 1.35 and a net ecosystem production (NEP) of 794 g C m−2 a−1 (= global NEP of 117 Tg C a−1), reflecting net autotrophy. CORG burial is 5% and 9% of GPPE and NEPE, respectively. Mean RE/GPPE is 0.74 and carbon use efficiency averages 0.57, higher than for tropical humid forests (0.35).
A Body Shape Index (ABSI) as a Variant of Conicity Index Not Affected by the Obesity Paradox: A Cross-Sectional Study Using Arterial Stiffness Parameter
Authors: Nagayama Daiji , Fujishiro Kentaro , Watanabe Yasuhiro , Yamaguchi Takashi , Suzuki Kenji , Saiki Atsuhito , Shirai Kohji
Published: December 2022

A body shape index (ABSI) is an abdominal obesity index developed based on epidemiological statistics and designed to correlate minimally with body mass index (BMI). We examined the approximation between ABSI and other abdominal obesity indices based on biophysical concepts. The cross-sectional data from 62,514 Japanese urban residents were analyzed. Body adiposity indices comprising BMI, waist circumference (WC), ABSI, conicity index (CI), waist-to-height ratio (WHtR), and WC/BMI ratio were examined. ABSI and CI more strongly correlated with age and arterial stiffness assessed by cardio-ankle vascular index (CAVI) compared to the other indices. The discriminative power for high CAVI (≥9.0) was the strongest for ABSI followed by CI and other indices, in that order. The range and distribution of WC corresponding to the cutoff of ABSI (0.0801), or CI (1.23) seemed reasonable. The correlation between ABSI and CI was the strongest compared to any other combination of indices. CI correlated moderately with BMI, whereas ABSI correlated minimally with BMI. ABSI correlates strongly and approximates closely with CI. Hence, ABSI may be considered to reflect the degree of body shape change from cylindricity to conicity and is currently the only abdominal obesity index not affected by the obesity paradox.
Strategic Business Mode Choices for E-Commerce Platforms under Brand Competition
Authors: Yu Jing , Zhao Jingjing , Zhou Chi , Ren Yufei
Published: December 2022

Relying on the rapid development of information and internet technologies, e-commerce has boomed over the past decade. As a link between manufacturers and consumers, the e-commerce platform has a crucial position in the online retailing market. The e-commerce platform not only provides an online marketplace through which the manufacturers directly sell products to consumers but also purchases and resells manufacturers’ products to consumers. Therefore, when the e-commerce platform provides services to manufacturers, it is faced with the selection of two sales methods: reselling or marketplace. Using a game theoretic model, we focus on the strategic interactions between an e-commerce platform and two brand manufacturers in four different business modes. The results show that the e-commerce platform profits more when both brand manufacturers directly sell products through the online marketplace. From the two brand manufacturers’ points of view, using the e-commerce platform as a reseller is always more profitable than directly selling, no matter which business mode they are in. The above findings have important implications for the selling decisions of the e-commerce platform and brand manufacturers. Furthermore, an interesting and counterintuitive result is that the new brand manufacturer benefits more than the existing brand manufacturer when consumers’ acceptance of the new brand products is becoming lower. When production costs are low, only the two brand manufacturers can achieve a mutually beneficial situation by selling products to the e-commerce platform. Moreover, the competition among brand manufacturers is beneficial to the e-commerce platform. Our research provides a theoretical basis for brand manufacturers and the e-commerce platform to make more rational decisions, and it updates the existing knowledge about brand competition and e-commerce platform’s business mode choices.
Ecosystem Service Values as Related to Land Use and Land Cover Changes in Ethiopia: A Review
Authors: Biedemariam Muluberhan , Birhane Emiru , Demissie Biadgilgn , Tadesse Tewodros , Gebresamuel Girmay , Habtu Solomon
Published: December 2022

Humans worldwide depend on ecosystems and the services they provide. Land use and land cover change increasingly, influencing ecosystem values to the extent that the rate and direction of change occurred. The objective of this study was to review the link between changes in Land Use and Land Cover (LULC) and Ecosystem Service Value (ESV), with emphasis on mountainous landscapes in Ethiopia. The reviewers used the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline in the reviewing process. Area-specific and country-level studies showed that the ESV changed as the result of the LULC changes in the country. The change in land use in Ethiopia resulted not only in the loss of ESVs but also in the gain of ESVs depending on the type of man’s activity. Negative change in LULC—especially the deterioration of land cover types such as forest land, shrub land and grass land—resulted in the loss of ESVs, whereas positive LULC change increased the value of ESVs. In Ethiopia, there is a loss of about USD 85 billion per year from the loss of ecosystem services. To save, improve and promote ESVs, land restoration and rehabilitation activities are important. The review provides insights into the need for and focus of future studies on LULC changes and the valuing of ESVs to understand the impact of changes in LULC on ESVs, considering existing and forecasted population increase in rapidly urbanizing areas.
Land Productivity and Agri-Environmental Indicators: A Case Study of Western Balkans
Authors: Đokić Danilo , Matkovski Bojan , Jeremić Marija , Đurić Ivan
Published: December 2022

Due to the environmental radicalization of European politics, which is reflected in the European Green Deal, Farm to Fork strategy, and new CAP 2023–2027, this paper aims to determine the impact of agri-environmental indicators on soil productivity based on the land productivity function model. The paper focuses on the Western Balkans countries, which are in the process of European integration and which, in the coming period, need to harmonize their agricultural policy with the CAP. First, the aggregate Cobb–Douglas production function has been used to create a land productivity function. Then, the sources of land productivity growth have been calculated, which can be particularly interesting in the context of agri-environmental indicators, such as fertilizer use and livestock density. The research results showed that land productivity is the most elastic concerning changes in the number of livestock units per hectare. Consequently, reducing livestock units had a markedly negative effect on productivity. In addition, the research results showed that using mineral fertilizers is a crucial source of growth in land productivity in these countries. These results imply that the creators of the agricultural policy must carefully assess the pace at which they will harmonize ecological and economic goals, especially if they take into account the current Ukraine crisis that can disrupt the food market.