bluuebunny/crossref_metadata_2025 huggingface dataset:
Insomnia, OSA, and Mood Disorders: The Gut Connection
Authors: Pacheco André P. , Cedernaes Jonathan , Benedict Christian
Published: October 2024

Purpose of Review

With the growing body of research examining the link between sleep disorders, including insomnia and obstructive sleep apnea (OSA), and the gut microbiome, this review seeks to offer a thorough overview of the most significant findings in this emerging field.

Recent Findings

Current evidence suggests a complex association between imbalances in the gut microbiome, insomnia, and OSA, with potential reciprocal interactions that may influence each other. Notably, specific gut microbiome species, whether over- or under-abundant, have been associated with variation in both sleep and mood in patients diagnosed with, e.g., major depressive disorder or bipolar disorder.

Further studies are needed to explore the potential of targeting the gut microbiome as a therapeutic approach for insomnia and its possible effects on mood. The variability in current scientific literature highlights the importance of establishing standardized research methodologies.
Novel 3-D Macrophage Spheroid Model Reveals Reciprocal Regulation of Immunomechanical Stress and Mechano-Immunological Response
Authors: Burchett Alice , Siri Saeed , Li Jun , Lu Xin , Datta Meenal
Published: October 2024

Purpose

In many diseases, an overabundance of macrophages contributes to adverse outcomes. While numerous studies have compared macrophage phenotype after mechanical stimulation or with varying local stiffness, it is unclear if and how macrophages directly contribute to mechanical forces in their microenvironment.

Methods

Raw 264.7 murine macrophages were embedded in a confining agarose gel, and proliferated to form spheroids over days/weeks. Gels were synthesized at various concentrations to tune stiffness and were shown to support cell viability and spheroid growth. These cell-agarose constructs were treated with media supplements to promote macrophage polarization. Spheroid geometries were used to computationally model the strain generated in the agarose by macrophage spheroid growth. Agarose-embedded macrophages were analyzed for viability, spheroid size, stress generation, and gene expression.

Results

Macrophages form spheroids and generate growth-induced mechanical forces (i.e., solid stress) within confining agarose gels, which can be maintained for at least 16 days in culture. Increasing agarose concentration increases gel stiffness, restricts spheroid expansion, limits gel deformation, and causes a decrease in Ki67 expression. Lipopolysaccharide (LPS) stimulation increases spheroid growth, though this effect is reversed with the addition of IFNγ. The mechanosensitive ion channels Piezo1 and TRPV4 have reduced expression with increased stiffness, externally applied compression, LPS stimulation, and M1-like polarization.

Conclusions

Macrophages alone both respond to and generate solid stress. Understanding how macrophage generation of growth-induced solid stress responds to different environmental conditions will help to inform treatment strategies for the plethora of diseases that involve macrophage accumulation and inflammation.
Upper Devonian to Mississippian global environmental change and impact on conodonts
Authors: Hartenfels Sven
Published: October 2024

The Upper Devonian to Mississippian was a very dynamic time in Earth’s history and encompassed substantial changes in widely separated palaeoenvironments. Major evolutionary trends did not occur through a long-lasting interval of ecological stability, instead they took place as recurring global events and/or crises of different magnitude, duration, and intensity. Framed by two of the most devastating time intervals – the Kellwasser and the Hangenberg crises – the Famennian has yielded other 2nd to 5th order events/crises. Many of these smaller scaled events show similarities with specific episodes of the longer-lasting crises and can especially be recognised in weakly tectonised pelagic facies that was present globally in a pan-tropical belt from North America to North Africa, Europe, Asia, and Australia. The search for causes of the Upper Devonian to Mississippian event/crisis sequence has made progress in the last few years. Nevertheless, we are still far from understanding all factors and reasons, which have triggered these environmental changes. The impact of Upper Devonian to Mississippian events/crises on faunal groups, such as ammonoids, has attracted many researches in past decades. Although, living in identical outer shelf settings, the different effects on conodonts have not yet received the attention they deserved in the context of our aim to understand the global environmental hazards of the past. One of the key questions is to understand, which and how environmental change influenced and/or stimulated the evolution of conodonts.
Secular Mindfulness as Skilful Means (Upaya-kaushalya)
Authors: Karunavira Dh.
Published: October 2024

This paper explores a pivotal question raised by a group of Indian Mindfulness-based Stress Reduction (MBSR) trainee teachers from poor, ex-Dalit communities who converted to Buddhism in the mid-1950s. The question—“How is this MBSR meditation different from the meditation we do as Buddhists?”—highlights the perceived differences between traditional Buddhist meditation aimed at enlightenment and secular mindfulness practices designed to alleviate psychological and emotional distress. Adopting a somewhat heuristic approach, using the Buddhist Wheel of Life, the discussion elucidates how MBSR can be viewed as a contemporary skilful means (upaya-kaushalya) designed to alleviate various forms of suffering without religious affiliation. This perspective aligns MBSR with Buddhist compassion principles, addressing tensions about whether contemporary Mindfulness-based Interventions (MBIs) dilute the Buddha’s teachings (Dharma). By positioning MBIs within the broader context of skill-in-means, this paper underscores their role in extending compassion to those who might not seek traditional religious teachings, thus bridging the gap between secular and spiritual practices. This discussion aims to deepen the understanding of MBSR as a legitimate and compassionate extension of Buddhist principles, adapted for contemporary needs.
Isolation and characterization of mung bean (Vigna radiata L.) rhizobia in Myanmar
Authors: Htwe Aung Zaw , Yamakawa Takeo , Ishibashi Matsujiro , Tsurumaru Hirohito
Published: October 2024

We collected soil samples from six major mung bean cropping regions in Myanmar: Sagaing, Mandalay, Nay Pyi Taw, and Magway in the tropical savanna climate zone and Bago and Yangon in the tropical monsoon climate zone. All fields grew mung bean for at least 5 years and had no history of rhizobial inoculation. Mung bean ‘Yezin-11’, a popular cultivar in Myanmar, was inoculated with soil suspensions. From the nodules formed on the roots, we isolated 55 rhizobial strains. Identification of the isolates revealed the dominant species of indigenous rhizobia in each region. We identified 53 Bradyrhizobium strains and 2 Ensifer strains. Bradyrhizobium yuanmingense was dominant in the tropical savanna zone and Bradyrhizobium sp. (B. liaoningense or B. diversitatis) and B. centrosematis were dominant in the tropical monsoon zone. Principal component analysis indicates that the dominance of B. yuanmingense in the tropical savanna zone might be due to high concentration of NO3-N and P2O5 in the soil. It also indicates that the dominance of B. centrosematis in the tropical monsoon zone might be caused by drastically low pH and high concentration of NH4 in the soil. Bradyrhizobium centrosematis YGN-M9, B. yuanmingense SGG-M3, and Bradyrhizobium sp. BGO-M5 significantly increased nodulation (nodule number and nodule dry weight), acetylene reduction activity, and shoot dry weight, respectively, relative to Ensifer terangae MDY-M6. Co-inoculation with these three strains increased nodulation significantly compared with single inoculation of BGO-M5. The characterization of mung bean rhizobia and selection of microbial inoculant candidates will be useful for the development of microbial inoculants in Myanmar.
Origin and Characteristics of Ore-Forming Fluids of the Abu Gaharish Orogenic Gold Deposits, Central Eastern Desert, Egypt: Evidence from Alteration Geochemistry, Mineral Chemistry and Fluid Inclusions
Authors: Mahmoud Abdelhalim S. , El-Dokouny Hanaa A. , Ghoneim Mohamed M. , Dolomanova-Topol Arizh A. , Dyakonov Viktor V. , Vikent’ev Ilya V. , El-Lithy Mai A. , Dawoud Maher
Published: October 2024

The Abu Gaharish mineralization comprises Au-rich NNE-trending quartz veins, and their surrounding shear zone is found hosted within a Neoproterozoic Sn-W-bearing monzogranite pluton and intersects the metavolcano-sedimentary assemblage at its eastern contact. The ore mineralogy consists of pyrite, galena, chalcopyrite, sphalerite, and gold, with secondary vanadinite occurring after galena and hematite after pyrite. Paragenesis reveals two generations of pyrite and galena, where gold formed mainly during the early sulfidation stage and mobilized upon later deformation events and incipient recrystallization. Mass balance calculations on the alteration zones reveal that the inputs upon alteration included Al2O3, Fe2O3, K2O, MgO, P2O5 W, Rb, Cu, Zn, Pb, V, Cr, Mo, Co, Sn, As, and U, whereas the outputs comprised SiO2, Na2O, CaO, MnO, Sr, Ba, Zr, Y, Th, Nb, and Ni, respectively, in decreasing order. The low contents of granitophile elements (such as Mo, Sn, and W) in the quartz veins at Abu Gaharish suggest that the gold-sulfide-quartz veins have no linkage with granitoid intrusion. However, the enrichment of these elements in the proximal alteration zone is attributed to their leaching by hydrothermal fluids from anomalous zones. The fluid inclusion data observed in quartz showcases the existence of CO2-bearing low-salinity fluids mixed with Mg, Na, and K chlorides under mesothermal conditions during the ore deposition process. This aligns with the formation of orogenic gold deposits as a consequence of the metamorphic devolatilization of the adjacent metavolcano-sedimentary succession. The characteristics of mineralizations at Abu Gaharish display resemblances to orogenic gold deposits and refute the intrusion-related model.
The Indigenous Tutorial Assistance Scheme from a tutor’s point of view: groundwork for a critical pedagogy
Authors: Enciso Stephen W.
Published: October 2024

The Indigenous Tutorial Assistance Scheme (ITAS) provides one-on-one tutoring for Indigenous students at Australian universities. Qualitative and quantitative research has consistently identified ITAS as a vital means of supporting Indigenous participation in tertiary education, while also lamenting a lack of clear guidelines for conducting the tutoring relationship. Clear guidelines are important for students to know what to expect from tutors and for tutors to understand their purpose. There has been little, if any, research conducted from the perspective of a tutor reflecting on the pedagogies employed as part of their involvement in ITAS. This article fills that gap by laying the groundwork for a critical pedagogy of ITAS tutoring. Drawing on the anti-hierarchical concepts of Jacques Rancière and an autoethnographic methodology, I suggest that tutors should adopt an abolitionist approach that empowers students and discourages dependency. I show how this method can be put into practice through a strategy I call Returning the Question. The aim of this article is to stimulate reflection among ITAS tutors on their pedagogical practice with the hope of improving the quality and efficacy of ITAS as a support service for Indigenous students at university.
The information matrix of the bivariate extended skew-normal distribution
Authors: Franco Stefano , Azzalini Adelchi
Published: October 2024

For the extended skew-normal distribution, which represents an extension of the normal (or Gaussian) distribution, we focus on the properties of the log-likelihood function and derived quantities in the bivariate case. Specifically, we derive explicit expressions for the score function and the information matrix, in the observed and the expected form; these do not appear to have been examined before in the literature. Ensuing numerical work illustrates some relevant aspects of the expected information matrix.
Neutrality of the Olympic Movement against recent developments in sport and geopolitics – need of reconceptualisation
Authors: Schubert Mathias
Published: October 2024

The Olympic Movement’s response to the Russian invasion of Ukraine underlines an existing dilemma on political neutrality and how the governance of sport has struggled to come to terms with the principle of political neutrality. The status of Russian and Belarussian athletes and teams in international sports is an ongoing disputative matter for the governance of sport. This paper aims to contribute to conceptional clarity concerning the principle of political neutrality and to spell out a specific application of political neutrality to the Olympic Movement in recognition of its commitment to human rights and promotion of peace. Accordingly, it observes neutrality in the practice of the Olympic Movement and challenges the applicability of the principle of neutrality in the social realm around politics and capitalism. The findings highlight the discrepancy between the Olympic Movement’s policies on political neutrality and its governance that eventually erode the autonomy of sport. The paper concludes by arguing for the need of reconceptualisation of the neutrality principle in (Olympic) sport. To address future global challenges that violate fundamental principles of international law, the paper proposes the incorporation of transparent procedures and limitations.
Academic Assessments and iPads: Performance of Students from a Low Performing Urban Elementary School
Authors: L. Reynolds Jennifer , B. Aspiranti Kathleen , E. C. Henze Erin , M. Kall Lauren
Published: October 2024

Technology in education is used to support and supplement core instruction, to help students stay engaged, and assist teachers with academic assessments. While there is support in the use of technology in instruction and intervention, researchers still urge caution when using it in assessment. Current evidence suggests that students perform differently when assessed using traditional methods compared to technology-based methods. Further, these differences may be exacerbated for students from low-income economically marginalized at-risk communities. There is a need to thoroughly explore student performance when responding to assessment materials through different modalities. The current investigation used a within subjects group design to replicate Reynolds et al. (2023) using an urban low performing population. Results demonstrate that, on average, students answered more digits correct per minute on probes administered via paper-pencil, however preferred to answer problems on the iPad using a keyboard. These results differ from the original study that used a higher performing suburban population. Future research, limitations, and implications for educators are discussed.
An Unprecedented Efficiency with Approaching 21% Enabled by Additive-Assisted Layer-by-Layer Processing in Organic Solar Cells
Authors: Xu Shuai , Zhang Youdi , Sun Yanna , Cheng Pei , Yao Zhaoyang , Li Ning , Ye Long , Zuo Lijian , Gao Ke
Published: October 2024

Recently published in Joule, Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8% power conversion efficiency in organic solar cells (OSCs) with an interpenetrating fibril network active layer morphology, featuring a bulk p-i-n structure and proper vertical segregation achieved through additive-assisted layer-by-layer deposition. This optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion, reduces recombination losses, and enhances light capture capability. This approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.
Developmental characteristics of vertical natural fracture in low-permeability oil sandstones and its influence on hydraulic fracture propagation
Authors: Yin Shuai , Radwan Ahmed E. , Xiao Feng , Xie Guochen , Lai Pengfei
Published: October 2024

Vertical natural fractures (NFs) are prevalent in low-permeability sandstone reservoirs. Presently, the impact of NFs on the extension of hydraulic fractures (HFs) remains partially unveiled, which restricts the scientific development of strategies for low-permeability, fractured oil sandstones. In this study, taking the oil sandstone of the He-3 Member, Hetaoyuan Formation, southeastern Biyang Depression as an example, we conducted a comprehensive investigation into the factors influencing vertical fracture development and the interaction between natural and hydraulic fractures. The cohesive unit simulations indicate that geostress is the principal factor influencing HF expansion, more so than NFs, with this influence intensifying as natural fracture density increases. As natural fracture density grows, the potential for two sets of conjugate natural fractures to form short HFs arises, which are limited in expansion scope, suggesting a need to reduce well spacing accordingly. Conversely, areas with a single set of NFs are more prone to developing longer HFs, warranting an increase in well spacing to avoid water channeling. High natural fracture densities may constrain the effectiveness of HFs. In fractured reservoirs with a 10 MPa horizontal stress difference, the length of HFs is 1.52 times that of HFs with 0 MPa and 5 MPa differences. However, the hydraulic fracture effectiveness index (FE) of the latter is 1.74 times higher than the former. For fractured reservoirs, the expansion capacity of HF length within a 5 MPa horizontal stress difference remains relatively stable; beyond this threshold, the expansion capacity increases with the growing horizontal stress difference, and the fracturing effect eventually deteriorates. Furthermore, as the strength of NFs escalates, the length and modified area of HFs initially decrease significantly before stabilizing. The complexity and FE value of HFs formed under strong natural fracture conditions are heightened, indicating a more effective fracturing outcome.
Discovering potential founders within academic institutions
Authors: Arzani Arman , Handte Marcus , Marrón Pedro José
Published: October 2024

Technology transfer is central to the development of an iconic entrepreneurial university. To foster knowledge transfer, many universities undergo a scouting process by their innovation coaches. The goal is to find staff members and students, who have the knowledge, expertise, and the potential to found startups by transforming their research results into a product. Since there is no systematic approach to measure the innovation potential of university members based on their academic activities, the scouting process is typically subjective and relies heavily on the experience of the innovation coaches. In this paper, we study the discovery of potential founders to support the scouting process using a data-driven approach. We create a novel data set by integrating the founder profiles with the academic activities from 8 universities across 5 countries. We explain the process of data integration as well as feature engineering. By applying machine learning methods, we investigate the classification accuracy of founders based on their academic background. Our analysis shows that using a random forest (RF), it is possible to differentiate founders and non-founders with an average accuracy of 79%. This accuracy remains mostly stable when applying an RF trained on one university to another, suggesting the existence of a generic founder profile. The detailed analysis indicates a high significance of the career path as well as patent- and grant-related features among others. Furthermore, we show that using a RF, it is possible to exploit these features to predict the future founding probability up to 3 years in advance with an accuracy of 80%. Finally, by analyzing the academic disciplines of founders we show that the patent documents have more influence on the startup’s core orientation than the publications.
Consumption patterns of indebted households: unravelling the relevance of fiscal policy
Authors: Afonso António , de Sá Fortes Leitão Rodrigues Eduardo
Published: October 2024

We have investigated the influence of fiscal instruments, notably taxes and government spending, on household consumption in two different samples and two measures of household debt to provide a comprehensive analysis of the topic. We used dynamic panel models and the Generalised Method of Moments (GMM) approach for 24 and 32 advanced and emerging countries from 1995 to 2020. Our findings show that fiscal impulses increase private consumption. However, when households are highly indebted, the effects are different, and the increase in public spending or the reduced taxes discourages household consumption compared to the baseline (lower debt) group. These results suggest a precautionary effect.
Crash dilemmas and the ethical design of self-driving vehicles: implications from metaethics and pragmatic road marks
Authors: Schäffner Vanessa
Published: October 2024

How should self-driving vehicles react when an accident can no longer be averted in dangerous situations? The complex issue of designing crash algorithms has been discussed intensively in recent research literature. This paper refines the discourse around a new perspective which reassesses the underlying dilemma structures in the light of a metaethical analysis. It aims at enhancing the critical understanding of both the conceptual nature and specific practical implications that relate to the problem of crash algorithms. The ultimate aim of the paper is to open up a way to building a bridge between the inherent structural issues of dilemma cases on the one hand and the characteristics of the practical decision context related to driving automation scenarios on the other. Based on a reconstruction of the metaethical structure of crash dilemmas, a pragmatic orientation towards the ethical design of crash algorithms is sketched and critically examined along two central particularities of the practical problem. Firstly, pertinent research on the social nature of crash dilemmas is found to be merely heuristic. Secondly, existing work from ethics of risk hardly offers explicit ethical solutions to relevant and urgent challenges. Further investigation regarding both aspects is ultimately formulated as a research desideratum.
SyROCCo: enhancing systematic reviews using machine learning
Authors: Fang Zheng , Arana-Catania Miguel , van Lier Felix-Anselm , Outes Velarde Juliana , Bregazzi Harry , Airoldi Mara , Carter Eleanor , Procter Rob
Published: October 2024

The sheer number of research outputs published every year makes systematic reviewing increasingly time- and resource-intensive. This paper explores the use of machine learning techniques to help navigate the systematic review process. Machine learning has previously been used to reliably “screen” articles for review – that is, identify relevant articles based on reviewers’ inclusion criteria. The application of machine learning techniques to subsequent stages of a review, however, such as data extraction and evidence mapping, is in its infancy. We, therefore, set out to develop a series of tools that would assist in the profiling and analysis of 1952 publications on the theme of “outcomes-based contracting.” Tools were developed for the following tasks: assigning publications into “policy area” categories; identifying and extracting key information for evidence mapping, such as organizations, laws, and geographical information; connecting the evidence base to an existing dataset on the same topic; and identifying subgroups of articles that may share thematic content. An interactive tool using these techniques and a public dataset with their outputs have been released. Our results demonstrate the utility of machine learning techniques to enhance evidence accessibility and analysis within the systematic review processes. These efforts show promise in potentially yielding substantial efficiencies for future systematic reviewing and for broadening their analytical scope. Beyond this, our work suggests that there may be implications for the ease with which policymakers and practitioners can access evidence. While machine learning techniques seem poised to play a significant role in bridging the gap between research and policy by offering innovative ways of gathering, accessing, and analyzing data from systematic reviews, we also highlight their current limitations and the need to exercise caution in their application, particularly given the potential for errors and biases.
Thrombocytopenia in dengue infection: mechanisms and a potential application
Authors: Khazali Ahmad Suhail , Hadrawi Waqiyuddin Hilmi , Ibrahim Fatimah , Othman Shatrah , Nor Rashid Nurshamimi
Published: October 2024

Thrombocytopenia is a common symptom and one of the warning signs of dengue virus (DENV) infection. Platelet depletion is critical as it may lead to other severe dengue symptoms. Understanding the molecular events of this condition during dengue infection is challenging because of the multifaceted factors involved in DENV infection and the dynamics of the disease progression. Platelet levels depend on the balance between platelet production and platelet consumption or clearance. Megakaryopoiesis and thrombopoiesis, two interdependent processes in platelet production, are hampered during dengue infection. Conversely, platelet elimination via platelet activation, apoptosis and clearance processes are elevated. Together, these anomalies contribute to thrombocytopenia in dengue patients. Targeting the molecular events of dengue-mediated thrombocytopenia shows great potential but still requires further investigation. Nonetheless, the application of new knowledge in this field, such as immature platelet fraction analysis, may facilitate physicians in monitoring the progression of the disease.
A singularly altered streamline topology allows faster transport from deformed drops
Authors: Singeetham Pavan Kumar , Thampi Sumesh P. , Subramanian Ganesh
Published: October 2024

We analyse the effect of drop-deformation-induced change in streamline topology on the scalar transport rate (the Nusselt number

$Nu$

) in an ambient planar linear flow. The drop-phase resistance is assumed dominant, and the drop deformation is characterised by the capillary number (

$Ca$

). For a spherical drop (

$Ca = 0$

) in an ambient planar extension, closed streamlines lead to

$Nu$

increasing with the Péclet number (

$Pe$

), from

$Nu_0$

, corresponding to purely diffusive transport, to

$4.1Nu_0$

, corresponding to a large-

$Pe$

diffusion-limited plateau. For non-zero

$Ca$

, we show that the flow field consists of spiralling streamlines densely wound around nested tori foliating the deformed drop interior. Now

$Nu$

increases beyond the aforementioned primary plateau, saturating in a secondary one that approaches

$22.3Nu_0$

for

$Ca \rightarrow 0$

,

$Pe\,Ca \rightarrow \infty$

. The enhancement appears independent of the drop-to-medium viscosity ratio. We further show that this singular dependence, of the transport rate on drop deformation, is generic across planar linear flows; chaotically wandering streamlines in some of these cases may even lead to a tertiary enhancement regime.
The dynamics of shock wave propagation far downstream of an abrupt area expansion
Authors: Gichon Yoav , Jose Jibu Tom , Chandravamsi Hemanth , Evron Yigal , Ram Omri
Published: October 2024

Predicting the transient flow fields that develop when a shock wave passes through an area expansion is a fundamental problem in compressible fluid mechanics and significant in many engineering applications. Experiments, large eddy simulations and geometrical shock dynamics are used to study the mechanism by which a normal shock wave that expands across an area expansion evolves into a uniform normal shock far downstream of it. This study analyses shock waves with moderate Mach numbers of 1.1–1.8 that expand at area ratios of up to 5. As the shock wave propagates into the expanded region, it experiences rapid deceleration, forming a non-uniform shock front. Impinging on the walls of the larger cross-section region, the shock wave reflects and generates a complex and highly transient shock pattern near the expansion region. We have found that as the shock front propagates further downstream, a laterally moving shock wave that intersects the shock front at a triple point reverberates laterally between the walls. This process effectively evens out the flow behind the incident shock front, thus reducing the variation of properties behind it. The extended duration of this process leads to significant pressure fluctuation behind the shock front. The results show that the evolution of the shock front can be scaled using the expanded region height and the velocity of the shock wave far downstream of the expansion. The results enabled the formulation of a simple empirical relation, allowing us to predict the shock velocity far downstream of gradual and abrupt area expansions.
A maternal low-protein diet results in sex-specific differences in synaptophysin expression and milk fatty acid profiles in neonatal rats
Authors: Bello-Medina Paola C. , Díaz-Muñoz Mauricio , Martín del Campo Sandra Teresita , Pacheco-Moisés Fermín Paul , Flores Miguel Claudia , Cobián Cervantes Raquel , García Solano Perla Belén , Navarro-Meza Mónica
Published: October 2024

The developmental origins of health and disease hypothesis have highlighted the link between early life environment and long-term health outcomes in offspring. For example, maternal protein restriction during pregnancy and lactation can result in adverse metabolic and cognitive outcomes in offspring postnatal. Hence, in the present study, we assess whether an isocaloric low-protein diet (ILPD) affects the fatty acid profile in breast milk, the hippocampal synaptophysin (Syn) ratio, and the oxidative stress markers in the neonatal stage of male and female offspring. The aim of this work was to assess the effect of an ILPD on the fatty acid profile in breast milk, quantified the hippocampal synaptophysin (Syn) ratio and oxidative stress markers in neonatal stage of male and female offspring. Female Wistar rats were fed with either a control diet or an ILPD during gestation to day 10 of lactation. Oxidative stress markers were assessed in serum and liver. All quantifications were done at postnatal day 10. The results showed: ILPD led to decreases of 38.5% and 17.4% in breast milk volume and polyunsaturated fatty acids content. Significant decreases of hippocampal Syn ratio in male offspring (decreases of 98% in hippocampal CA1 pyramidal and CA1 oriens, 83%, stratum pyramidal in CA3, 80%, stratum lucidum in CA3, and 81% stratum oriens in CA3). Male offspring showed an increase in pro-oxidant status in serum and liver. Thus, the data suggest that male offspring are more vulnerable than females to an ILPD during gestation and lactation.
Human Trafficking Dynamics and Prevention Efforts as an Outcome of Russia’s War on Ukraine
Authors: Dean Laura A.
Published: October 2024

Debates on the connection between human trafficking and war have been discussed in wars and conflicts across the globe. Russia’s war on Ukraine has brought this relationship to the forefront again, questioning whether trafficking flows have increased, examining the types of trafficking in war, and determining the conditions (if any) that make it flourish. This article examines human trafficking in Ukraine before the war and during limited and total war to determine how governments with robust anti-trafficking institutions negotiate anti-trafficking responses over different stages of war. The main research question of this study aims to determine how different stages of the war in Ukraine have changed human trafficking dynamics and responses over time. Using data from interviews and participant observations from Ukraine, I analyze the different types of human trafficking characteristics and flows, conditions that create vulnerabilities, and prevention tools that have been used in different periods. I theorize that war fundamentally alters human trafficking prevention but a foundation of prevention tools before war means that governments are better able to respond to human trafficking dynamics and flows when war occurs. Ukraine offers a unique and important perspective from which to examine human trafficking dynamics and the consequences of war due to a stable government, external aggressor, and clear path for those fleeing the violence to the European Union. The results show that Ukraine’s strong prevention efforts before the war helped shape responses after the war and full-scale invasion began. The data revealed that human trafficking is a longer-term form of gender-based violence in war because the exploitation is prolonged and there is a delay in identifying victims.
Multidimensional conflicts over disarmament and international security: analyzing speeches in the First Committee of the UN General Assembly
Authors: Finke Daniel , Risse Tobias
Published: October 2024

In this article, we explore the rhetorical space structuring the debates in the United Nations General Assembly's (UNGA) Committee on Disarmament and International Security. To this end, we unfold states' speeches by combining three established methods. First, we estimate terms' relevance for latent topics structuring the debates with structural topic modeling. Second, we estimate topic-specific positions based on the Wordfish algorithm. Third, we map these positions onto a lower-dimensional rhetorical space using principal component analysis. We identify two latent conflicts. First, a debate over conventional weapons with states emphasizing security interests on the one end and humanitarian interests on the other. Second, a conflict over weapons of mass destruction that divides defenders and challengers of the status quo.
FINITE GROUPS WHOSE CHARACTER CODEGREES ARE CONSECUTIVE INTEGERS
Authors: LEWIS MARK L. , YAN QUANFU
Published: October 2024

LetGbe a finite group. We investigate the structure of finite groups whose irreducible character codegrees are consecutive integers.
ON THE EVANS CHAIN COMPLEX
Authors: LIPPERT S. JOSEPH
Published: October 2024

We elaborate on the construction of the Evans chain complex for higher-rank graph

$C^*$

-algebras. Specifically, we introduce a block matrix presentation of the differential maps. These block matrices are then used to identify a wide family of higher-rank graph

$C^*$

-algebras with trivial K-theory. Additionally, in the specialised case where the higher-rank graph consists of one vertex, we are able to use the Künneth theorem to explicitly compute the homology groups of the Evans chain complex.
A brief history of antenatal colostrum expression, and where to from here
Authors: O’Sullivan Therese A. , Ihlein Connie N.
Published: October 2024

The practice of antenatal colostrum expression (ACE), or the extraction of colostrum from the breasts during pregnancy, has an interesting history and continues to evolve. This narrative review aims to describe how perception and practices of ACE have changed over time, summarise the evidence on ACE in maternal and infant care, and highlight areas for future research. The literature demonstrates that ACE is safe for low-risk women when done from around 36 weeks’ gestation. Women should be reassured that the skill of hand expressing is a valuable tool post-birth, regardless of whether they are able to collect colostrum antenatally or not. The collection and storage of colostrum in pregnancy can help avoid formula use in hospital, which may have follow on effects immune function and other areas. Ideally, colostrum collected during pregnancy would be kept safely frozen during the hospital stay and only defrosted and used during the stay if medically indicated, with parents supported through that process. Although ACE does not appear to improve long-term breastfeeding rates at present, it can increase confidence around breastfeeding. Further research in more diverse population groups, long-term breastfeeding and long-term health outcomes of using frozen antenatally expressed colostrum for babies (as compared to formula or fresh colostrum) would be valuable to gain a better understanding of the importance of ACE in maternity care.
Longitudinal association between depressive symptoms and cognitive function: the neurological mechanism of psychological and physical disturbances on memory
Authors: Dai Xiangwei , Liu Sihan , Li Xin , Chen Kewei , Gao Shudan , Wang Jun , Aarsland Dag , Han Zhuo Rachel , Zhang Zhanjun
Published: October 2024

Background

The neural correlates underlying late-life depressive symptoms and cognitive deterioration are largely unclear, and little is known about the role of chronic physical conditions in such association. This research explores both concurrent and longitudinal associations between late-life depressive symptoms and cognitive functions, with examining the neural substrate and chronic vascular diseases (CVDs) in these associations.

Methods

A total of 4109 participants (mean age = 65.4, 63.0% females) were evaluated for cognitive functions through various neuropsychological assessments. Depressive symptoms were assessed by the Geriatric Depression Scale and CVDs were self-reported. T1-weighted magnetic resonance imaging (MRI), diffusion tensor imaging, and functional MRI (fMRI) data were acquired in a subsample (n = 791).

Results

Cognitively, higher depressive symptoms were correlated with poor performance across all cognitive domains, with the strongest association with episodic memory (r = ‒0.138, p < 0.001). Regarding brain structure, depressive symptoms were negatively correlated with thalamic volume and white matter integrity. Further, white matter integrity was found to mediate the longitudinal association between depressive symptoms and episodic memory (indirect effect = −0.017, 95% CI −0.045 to −0.002) and this mediation was only significant for those with severe CVDs (β = −0.177, p = 0.008).

Conclusions

This study is one of the first to provide neural evidence elucidating the longitudinal associations between late-life depressive symptoms and cognitive dysfunction. Additionally, the severity of CVDs strengthened these associations, which enlightens the potential of managing CVDs as an intervention target for preventing depressive symptoms-related cognitive decline.
Why hospitals hire tobacco lobbyists: conflicts of interest among lobbyists’ clients
Authors: Strickland James M. , Chakravadhanula Naimisha
Published: October 2024

Lobbyists sometimes represent clients with seemingly adversarial policy interests. We seek to explain the occurrence of such ostensible conflicts of interest. In hiring lobbyists, interests encounter a tradeoff between access and agency. Although some lobbyists promise access to lawmakers, they may not lobby as contracted. Interests hire seemingly conflicted lobbyists more often when access is costlier and reputational risks are smaller. We examine the hiring of tobacco lobbyists by health interests, given the possibilities for shirking and reputational damage. We find that institutions such as hospitals hire tobacco lobbyists regularly and more often than membership-based health groups. Intergroup competition for access and lobby laws, especially anti-conflict laws, affect the use of tobacco lobbyists independent of rates of multi-client lobbying. Conflicts are more common today than ever but interests can protect themselves somewhat from opportunistic agents. Our findings also suggest that reforms can improve the representation of client interests.
Kinematic calibration of a 5-DOF double-driven parallel mechanism with sub-closed loop on limbs
Authors: Wang Xuhao , Sun Shuo , Wu Mengli , Cao Yiran , Guo Zhiyong , Liu Zefu
Published: October 2024

This paper proposes a kinematic calibration method of a novel 5-degree-of-freedom double-driven parallel mechanism with the sub-closed loop on limbs. At first, considering the introduction of a sub-closed loop significantly increased the complexity and difficulty of kinematic error modeling, an equivalent transformation method is proposed for the limb with a sub-closed loop. Then kinematic error model of the parallel mechanism is established based on the closed-loop vector method and parasitic motion analysis, which is verified by virtual prototype technology. Because the full kinematic error model is generally redundant, error parameter identifiability analysis is carried out by QR decomposition of the identification Jacobian matrix, and the redundant parameters are removed. Additionally, the Sequence Forward Floating Search algorithm is utilized to optimize measurement configurations to reduce the influence of measurement noise. Finally, with a laser tracker as the measuring device, numerical simulations and experiments are implemented to verify the proposed kinematic calibration method. The experiment results show that average position and orientation errors are reduced from 2.778 mm and 1.115° to 0.263 mm and 0.176°, respectively, within the prescribed workspace.
Small forest patches in West Africa: mapping how they are changing to better inform their conservation
Authors: Wingate Vladimir R , Curatola Fernández Giulia F , Ifejika Speranza Chinwe
Published: October 2024

In West Africa, vast areas are being deforested; the remnant forest patches provide a wealth of ecosystem services and biodiversity conservation potential, yet they are threatened by human activity. Forest patches <100 ha have not been widely catalogued before; we mapped forest loss of small forest patches outside of protected areas in the Guinean savannah and humid Guineo-Congolian bioclimatic regions of Togo, Benin, Nigeria and Cameroon between 2000 and 2022. Focusing on the dynamics of small patches, without considering the splitting process of larger patches, we quantified changes in their number and area and the rate and trend of forest loss. Small forest patches are widespread, yet their area and number have decreased, while the forest loss rate is increasing. Primary forest patches lost almost half of their area annually – twice as much as secondary forests, and this loss was especially pronounced across small patches (0.5 – 10 ha), suggesting deforestation preferentially occurs in the smallest patches of primary forest. If forest loss continues at the current rate, 14% of the total forest area mapped in this study will have disappeared by 2032, jeopardizing their potential to provide ecosystem services and emphasizing the need for measures to counter their deforestation.
What we talk about when we talk about ‘human shields’: Reading international law through images
Authors: Sayed Abdelghany
Published: October 2024

This article advocates a turn to the visual in legal scholarship. The phenomenon used to elucidate this methodological proposition is the figure of the ‘human shields’ under international humanitarian law, viewed from within the lived history of the peoples of the Global South. Today, the ‘human shields’ notion profoundly shapes how international law operates in scenes of intense organized violence. Once deployed, the human shields claim triggers a radical shift in the applicable international legal framework. After this point, harm to the civilian population and space can be legally authorized and justified. This article challenges the ways in which the ‘human shields’ notion continues to be debated in mainstream legal scholarship and discourse in terms of doctrinal interpretation, examination of evidence, or analyses of ‘asymmetricity’ and ‘urbanization’ as ‘challenges’ in ‘contemporary’ war. Before any such inquiries, I argue, it is crucial to pay attention to the visual and the lived history of the peoples of the Global South. Images that exist in the cultural realm – of and about war and crime, the human shielding spectacle and its actors, and Global South societies – structure and delimit the legal conversation and predetermine its possible outcomes. I propose, in sum, an attention to the visual as a site of the legal inquiry that can inform our understanding and critique of the law and politics of human shields. Images enable, rationalize and provoke the emotions necessary for an ‘exceptional’ operation of international law that authorizes massive violence against Global South spaces and peoples.
Bioethics at the bedside: considering the adolescent voice in withdrawal of life-sustaining therapy
Authors: Lynch Aine , Helmers Andrew , Jeewa Aamir , Haller Christoph , Kirsch Roxanne
Published: October 2024

Durable mechanical circulatory devices are commonly used to support children and adolescents in end-stage heart failure. However, these patients remain at high risk of acute medical complications, which may lead to significant impairment in functional capacity, altered quality of life, or death. We explore the incorporation of adolescent directives into medical decision-making in this scenario through a clinical case vignette.
Physical activity in the Fontan population: provider recommendations and patient actions
Authors: Pierick Alyson R. , Marshall Darren , Yu Sunkyung , Lowery Ray , Glenn Thomas , Hansen Jesse E. , Pickles Diane , Norris Mark D. , Russell Mark W. , Schumacher Kurt R.
Published: October 2024

Background:

Emerging evidence suggests that routine physical activity may improve exercise capacity, long-term outcomes, and quality of life in individuals with Fontan circulation. Despite this, it is unclear how active these individuals are and what guidance they receive from medical providers regarding physical activity. The aim of this study was to survey Fontan patients on personal physical activity behaviours and their cardiologist-directed physical activity recommendations to set a baseline for future targeted efforts to improve this.

Methods:

An electronic survey assessing physical activity habits and cardiologist-directed guidance was developed in concert with content experts and patients/parents and shared via a social media campaign with Fontan patients and their families.

Results:

A total of 168 individuals completed the survey. The median age of respondents was 10 years, 51% identifying as male. Overall, 21% of respondents spend > 5 hours per week engaged in low-exertion activity and only 7% spend > 5 hours per week engaged in high-exertion activity. In all domains questioned, pre-adolescents reported higher participation rates than adolescents. Nearly half (43%) of respondents reported that they do not discuss activity recommendations with their cardiologist.

Conclusions:

Despite increasing evidence over the last two decades demonstrating the benefit of exercise for individuals living with Fontan circulation, only a minority of patients report engaging in significant amounts of physical activity or discussing activity goals with their cardiologist. Specific, individualized, and actionable education needs to be provided to patients, families, and providers to promote and support regular physical activity in this patient population.