bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of Limiting Nutrients for Reclamation of Non-responsive Soils in Northern Ghana
Authors: Asei Rechiatu , Abaidoo Robert Clement , Opoku Andrews , Adjei-Nsiah Samuel , Antwi-Agyei Philip
Published: July 2021

A better understanding of soil fertility factors that constraint positive crop response to fertilizer inputs will facilitate the improvement of soil nutrient management. In this study, a nutrient omission trial was carried out in a greenhouse condition to identify soil chemical properties limiting in non-responsive soils and to ascertain their effect on soybean (Glycine max) production. The treatments evaluated were control (distilled water), complete nutrient solution (all nutrients), and complete solution with the omission of each of N, P, K, Ca, Mg, and S and micronutrients (Fe, Zn, Cu, Mn, B, and Mo) arranged in a completely randomized design with three replications. After the greenhouse study, the identified limiting nutrients were tested with or without FertiSoil (commercial compost) in a 3 year field experiment. Results of the soil analyses showed low fertility status of the non-responsive soils. The sufficiency quotient index revealed non-responsive soils in all the sites to be predominantly limiting in P and K. The occurrence of other limiting nutrients was also identified: Pishegu (Zn, B), Serekpere (Mg, S), Daffiama Saapare (Ca, Mg, S), and Naaga (Mg, S, Zn, B). The nutrient inputs positively influenced soybean yield response in all the locations. The application of PKZnB with FertiSoil and FertiSoil alone significantly increased soybean grain yields by 585 and 477 kg ha−1, respectively, at Pishegu. Soybean grain yields also increased by 585, 573, and 364 kg ha−1under the FertiSoil, PKMgS + FertiSoil, and PKMgS applications at Serekpere, respectively. At Daffiama Saapare, the highest (103%) percent increase in soybean grain yield was recorded from the combined application of PKMgSCa and FertiSoil. However, the application of FertiSoil and PKMgSCa singly equally increased soybean grain yield by 77%. Percent soybean grain yield increases of 86, 84, and 74% were observed when PKMgSZnB + FertiSoil, PKMgSZnB, and FertiSoil were applied, respectively, at Naaga. In absolute terms, 83% of the fields had a positive response to mineral fertilizer and 93% to FertiSoil and mineral fertilizer + FertiSoil applications. Organic amendment and/or site-specific fertilizer applications are the best options for alleviating poor or no crop responses to inputs and improve productivity on non-responsive soils.
Static and Dynamic Recidivism Risk Factors of People Who Have Committed Child Sex Offenses in Sport
Authors: Vertommen Tine , Verhelle Helena , Martijn Frederica M. , De Boeck Minne
Published: July 2021

Current knowledge of people who commit child sex offenses (PCSO) in sport contexts is based on descriptive information from cross-sectional self-report studies of survivors and media coverage of court cases. In-depth scientific analyses of characteristics, interpersonal dynamics, and applied theories of sexual offending in sport are largely absent. This paper starts with a description of available Belgian data on PCSO in sport, coming from self-reports in community samples, reported cases in the media, and interviews with survivors. The main goal of this study is the analysis of treatment file information from 16 convicted PCSO in sport using two actuarial recidivism assessment instruments (STATIC-99R and STABLE-2007). Overall, the majority of the included PCSO's risk assessments indicated relatively low risk of sexual recidivism. Notable was the preponderance of high risk scores on items related to exclusively unrelated victims, male victims, sexual deviance, and the absence of an intimate relationship. Other static and dynamic factors related to the risk of sexual recidivism, e.g., (prior) non-sexual violent offenses, unknown victims, hostility toward women, lack of concern for others, and poor cooperation with supervisors were rated relatively low in this sample of PCSO in sport. The findings point toward the complex and nuanced patterns that underlie child sexual abuse in sport. The current findings bring us one step closer to filling in the puzzle of child sexual abuse in sport and will help inform evidence- and experience-based prevention and intervention efforts.
Buffer-Capacity-Based Livelihood Resilience to Stressors—An Early Warning Tool and Its Application in Makueni County, Kenya
Authors: Matter Selina , Boillat Sébastien , Ifejika Speranza Chinwe
Published: July 2021

Persistent vulnerability of smallholder farmers to natural hazards and livelihood insecurity call for the identification of measures that enhance the resilience of their agriculture-dependent livelihoods. Without understanding how to secure smallholder livelihoods against adverse social-ecological dynamics, especially related to climate variability and market failures, hunger, poverty, and livelihood collapse are likely to become more entrenched. This study aims for this better understanding by applying the Livelihood Resilience Indicator Framework to investigate the livelihood resilience of smallholder farmers in Makueni County, Kenya, to disease and pest infestations, low yields, and hunger. We analyzed the buffer capacity dimension of resilience among smallholder farmers, using survey data collected in 2016 on 134 households. We conducted principal component analysis to calculate a buffer capacity index at household level, which we then assessed in relation to crop and livestock pests and diseases, yields, and food shortage. We found that there was a significant positive correlation between buffer capacity and maize yields, which could be attributed to diversity in agricultural practices and income. The incidence of pests and diseases correlated significantly and negatively with buffer capacity and specifically with land size, economic status, and social capital. While no significant relationship could be established between buffer capacity and the occurrence of food insecurity, this variable correlated with access to land and livestock, diversity in agricultural practices, and access to infrastructure. The expected positive relation between food security and access to infrastructure and services turned out to be negative, raising questions about the relations between the livelihood resilience construct and rural infrastructure and services. More differentiation is thus needed on the multi-faceted interactions between access to infrastructure and services, including their actual use and benefits to livelihood resilience. In general, most findings supported the Livelihood Resilience Indicator Framework in that households with higher buffer capacity were better equipped to cope with shocks and stressors, hence demonstrating the potential of the framework as an early warning tool.
Comparison Between Ultrasonographic and Standing Magnetic Resonance Imaging Findings in the Podotrochlear Apparatus of Horses With Foot Pain
Authors: Evrard Laurence , Joostens Zoë , Vandersmissen Maxime , Audigié Fabrice , Busoni Valeria
Published: July 2021

This prospective study aimed to blindly compare the ultrasonographic and standing magnetic resonance imaging (sMRI) findings in deep digital flexor tendon (DDFT), navicular bone, and navicular bursa in horses with foot pain, positive digital analgesia, and without definitive radiographic diagnosis. Ultrasonography detected more DDFT abnormalities (32/34 feet vs. 27/34 with sMRI) but identified less palmar navicular abnormalities (23/34 feet vs. 30/34 with sMRI). In suprasesamoidean DDFT lesions, which were mainly dorsally located, changes in echogenicity did not correspond to a particular pattern of sMRI signal change. Transcuneal ultrasonography did not allow assessment of morphology and extent of distal DDFT lesions, and sporadically discriminated the affected lobe compared to sMRI. Defects of the palmar compact bone were identified with both modalities except a parasagittal defect, which was only seen at sMRI.
The New Porcine Epidemic Diarrhea Virus Outbreak May Mean That Existing Commercial Vaccines Are Not Enough to Fully Protect Against the Epidemic Strains
Authors: Gao Qi , Zheng Zezhong , Wang Heng , Yi Songqiang , Zhang Guihong , Gong Lang
Published: July 2021

Background: On October 30, 2020, piglets and sows in the farrowing house of a pig farm in Jiangxi showed clinical symptoms such as anorexia, watery diarrhea, and vomiting. Epidemiological test, clinical necropsy, and RT-PCR test were carried out on the pig farm for diagnosis. After comprehensive considerations, the disease was judged as porcine epidemic diarrhea virus infection.

Results: Thereafter, a series of comprehensive prevention and control measures such as emergency vaccination with autogenous vaccines were adopted. Half a month after inoculation with autogenous vaccines for the farm, the mortality rate of newborn piglets in the farrowing house began to decline, and production gradually returned to being stable. The second-generation sequencing analysis and phylogenetic analysis showed that the porcine epidemic diarrhea virus (PEDV) sequence obtained from the stool and small intestine samples of the diseased pigs on the farm was 97.8% homologous to the vaccine strain. At the same time, antibody testing found that the vaccinated pigs on the pig farm had satisfactory immune response.

Conclusion: This case indicated that the PEDV outbreak on the pig farm might aggravate owing to the strain being mutated and could escape the immune protection of the existing vaccine. This case has accumulated technical data for the clinical prevention and control of porcine epidemic diarrhea.
Blood Arsenic Levels as a Marker of Breast Cancer Risk among BRCA1 Carriers
Authors: Marciniak Wojciech , Matoušek Tomáš , Domchek Susan , Paradiso Angelo , Patruno Margherita , Irmejs Arvids , Roderte Irita , Derkacz Róża , Baszuk Piotr , Kuświk Magdalena , Cybulski Cezary , Huzarski Tomasz , Gronwald Jacek , Dębniak Tadeusz , Falco Michał , Lener Marcin R. , Jakubowska Anna , Pullella Katherine , Kotsopoulos Joanne , Narod Steven , Lubiński Jan
Published: July 2021

An important group of breast cancers is those associated with inherited susceptibility. In women, several predisposing mutations in genes involved in DNA repair have been discovered. Women with a germline pathogenic variant in BRCA1 have a lifetime cancer risk of 70%. As part of a larger prospective study on heavy metals, our aim was to investigate if blood arsenic levels are associated with breast cancer risk among women with inherited BRCA1 mutations. A total of 1084 participants with pathogenic variants in BRCA1 were enrolled in this study. Subjects were followed from 2011 to 2020 (mean follow-up time: 3.75 years). During that time, 90 cancers were diagnosed, including 67 breast and 10 ovarian cancers. The group was stratified into two categories (lower and higher blood As levels), divided at the median (<0.85 µg/L and ≥0.85 µg/L) As level among all unaffected participants. Cox proportional hazards models were used to model the association between As levels and cancer incidence. A high blood As level (≥0.85 µg/L) was associated with a significantly increased risk of developing breast cancer (HR = 2.05; 95%CI: 1.18–3.56; p = 0.01) and of any cancer (HR = 1.73; 95%CI: 1.09–2.74; p = 0.02). These findings suggest a possible role of environmental arsenic in the development of cancers among women with germline pathogenic variants in BRCA1.
OB-Folds and Genome Maintenance: Targeting Protein–DNA Interactions for Cancer Therapy
Authors: Par Sui , Vaides Sofia , VanderVere-Carozza Pamela S. , Pawelczak Katherine S. , Stewart Jason , Turchi John J.
Published: July 2021

Genome stability and maintenance pathways along with their requisite proteins are critical for the accurate duplication of genetic material, mutation avoidance, and suppression of human diseases including cancer. Many of these proteins participate in these pathways by binding directly to DNA, and a subset employ oligonucleotide/oligosaccharide binding folds (OB-fold) to facilitate the protein–DNA interactions. OB-fold motifs allow for sequence independent binding to single-stranded DNA (ssDNA) and can serve to position specific proteins at specific DNA structures and then, via protein–protein interaction motifs, assemble the machinery to catalyze the replication, repair, or recombination of DNA. This review provides an overview of the OB-fold structural organization of some of the most relevant OB-fold containing proteins for oncology and drug discovery. We discuss their individual roles in DNA metabolism, progress toward drugging these motifs and their utility as potential cancer therapeutics. While protein–DNA interactions were initially thought to be undruggable, recent reports of success with molecules targeting OB-fold containing proteins suggest otherwise. The potential for the development of agents targeting OB-folds is in its infancy, but if successful, would expand the opportunities to impinge on genome stability and maintenance pathways for more effective cancer treatment.
Circulating MicroRNAs in Gastrointestinal Cancer
Authors: Ohtsuka Masahisa , Iwamoto Kazuya , Naito Atsushi , Imasato Mitsunobu , Hyuga Satoshi , Nakahara Yujiro , Mikamori Manabu , Furukawa Kenta , Moon Jeongho , Asaoka Tadafumi , Kishi Kentaro , Shamma Awad , Akamatsu Hiroki , Mizushima Tsunekazu , Yamamoto Hirofumi
Published: July 2021

Gastrointestinal cancer (GIC) is a common disease and is considered to be the leading cause of cancer-related death worldwide; thus, new diagnostic and therapeutic strategies for GIC are urgently required. Noncoding RNAs (ncRNAs) are functional RNAs that are transcribed from the genome but do not encode proteins. MicroRNAs (miRNAs) are short ncRNAs that are reported to function as both oncogenes and tumor suppressors. Moreover, several miRNA-based drugs are currently proceeding to clinical trials for various diseases, including cancer. In recent years, the stability of circulating miRNAs in blood has been demonstrated. This is of interest because these miRNAs could be potential noninvasive biomarkers of cancer. In this review, we focus on circulating miRNAs associated with GIC and discuss their potential as novel biomarkers.
Changes in Stem Cell Regulation and Epithelial Organisation during Carcinogenesis and Disease Progression in Gynaecological Malignancies
Authors: Cunnea Paula , Fotopoulou Christina , Ploski Jennifer , Trillsch Fabian , Mahner Sven , Kessler Mirjana
Published: July 2021

Gynaecological malignancies represent a heterogeneous group of neoplasms with vastly different aetiology, risk factors, molecular drivers, and disease outcomes. From HPV-driven cervical cancer where early screening and molecular diagnostics efficiently reduced the number of advanced-stage diagnosis, prevalent and relatively well-treated endometrial cancers, to highly aggressive and mostly lethal high-grade serous ovarian cancer, malignancies of the female genital tract have unique presentations and distinct cell biology features. Recent discoveries of stem cell regulatory mechanisms, development of organoid cultures, and NGS analysis have provided valuable insights into the basic biology of these cancers that could help advance new-targeted therapeutic approaches. This review revisits new findings on stemness and differentiation, considering main challenges and open questions. We focus on the role of stem cell niche and tumour microenvironment in early and metastatic stages of the disease progression and highlight the potential of patient-derived organoid models to study key events in tumour evolution, the appearance of resistance mechanisms, and as screening tools to enable personalisation of drug treatments.
Enhanced Paclitaxel Efficacy to Suppress Triple-Negative Breast Cancer Progression Using Metronomic Chemotherapy with a Controlled Release System of Electrospun Poly-d-l-Lactide-Co-Glycolide (PLGA) Nanofibers
Authors: Hsu Ming-Yi , Hsieh Cheng-Hsien , Huang Yu-Ting , Chu Sung-Yu , Chen Chien-Ming , Lee Wei-Jiunn , Liu Shih-Jung
Published: July 2021

Triple-negative breast cancer (TNBC) is highly aggressive and responds poorly to conventional chemotherapy. The challenge of TNBC therapy is to maximize the efficacies of conventional chemotherapeutic agents and reduce their toxicities. Metronomic chemotherapy using continuous low-dose chemotherapy has been proposed as a new treatment option, but this approach is limited by the selection of drugs. To improve antitumor therapeutic effects, we developed electrospun paclitaxel-loaded poly-d-l-lactide-co-glycolide (PLGA) nanofibers as a topical implantable delivery device for controlled drug release and site-specific treatment. The subcutaneously implanted paclitaxel-loaded nanofibrous membrane in mice was compatible with the concept of metronomic chemotherapy; it significantly enhanced antitumor activity, inhibited local tumor growth, constrained distant metastasis, and prolonged survival compared with intraperitoneal paclitaxel injection. Furthermore, under paclitaxel-loaded nanofiber treatment, systemic toxicity was low with a persistent increase in lean body weight in mice; in contrast, body weight decreased in other groups. The paclitaxel-loaded nanofibrous membranes provided sustained drug release and site-specific treatment by directly targeting and changing the tumor microenvironment, resulting in low systemic toxicity and a significant improvement in the therapeutic effect and safety compared with conventional chemotherapy. Thus, metronomic chemotherapy with paclitaxel-loaded nanofibrous membranes offers a promising strategy for the treatment of TNBC.
Immune Checkpoint Blockade for Metastatic Uveal Melanoma: Patterns of Response and Survival According to the Presence of Hepatic and Extrahepatic Metastasis
Authors: Koch Elias , Petzold Anne , Wessely Anja , Dippel Edgar , Gesierich Anja , Gutzmer Ralf , Hassel Jessica , Haferkamp Sebastian , Hohberger Bettina , Kähler Katharina , Knorr Harald , Kreuzberg Nicole , Leiter Ulrike , Loquai Carmen , Meier Friedegund , Meissner Markus , Mohr Peter , Pföhler Claudia , Rahimi Farnaz , Schadendorf Dirk , Schell Beatrice , Schlaak Max , Terheyden Patrick , Thoms Kai-Martin , Schuler-Thurner Beatrice , Ugurel Selma , Ulrich Jens , Utikal Jochen , Weichenthal Michael , Ziller Fabian , Berking Carola , Heppt Markus ,   on behalf of the German Dermatologic Cooperative Oncology Group (DeCOG, Committee Ocular Melanoma)
Published: July 2021

Background: Since there is no standardized and effective treatment for advanced uveal melanoma (UM), the prognosis is dismal once metastases develop. Due to the availability of immune checkpoint blockade (ICB) in the real-world setting, the prognosis of metastatic UM has improved. However, it is unclear how the presence of hepatic and extrahepatic metastasis impacts the response and survival after ICB. Methods: A total of 178 patients with metastatic UM treated with ICB were included in this analysis. Patients were recruited from German skin cancer centers and the German national skin cancer registry (ADOReg). To investigate the impact of hepatic metastasis, two cohorts were compared: patients with liver metastasis only (cohort A, n = 55) versus those with both liver and extra-hepatic metastasis (cohort B, n = 123). Data were analyzed in both cohorts for response to treatment, progression-free survival (PFS), and overall survival (OS). The survival and progression probabilities were calculated with the Kaplan–Meier method. Log-rank tests, χ2 tests, and t-tests were performed to detect significant differences between both cohorts. Results: The median OS of the overall population was 16 months (95% CI 13.4–23.7) and the median PFS, 2.8 months (95% CI 2.5–3.0). The median OS was longer in cohort B than in cohort A (18.2 vs. 6.1 months; p = 0.071). The best objective response rate to dual ICB was 13.8% and to anti-PD-1 monotherapy 8.9% in the entire population. Patients with liver metastases only had a lower response to dual ICB, yet without significance (cohort A 8.7% vs. cohort B 16.7%; p = 0.45). Adverse events (AE) occurred in 41.6%. Severe AE were observed in 26.3% and evenly distributed between both cohorts. Conclusion: The survival of this large cohort of patients with advanced UM was more favorable than reported in previous benchmark studies. Patients with both hepatic and extrahepatic metastasis showed more favorable survival and higher response to dual ICB than those with hepatic metastasis only.
Neuroblastoma Molecular Risk-Stratification of DNA Copy Number and ALK Genotyping via Cell-Free Circulating Tumor DNA Profiling
Authors: Kahana-Edwin Smadar , Cain Lucy E. , McCowage Geoffrey , Darmanian Artur , Wright Dale , Mullins Anna , Saletta Federica , Karpelowsky Jonathan
Published: July 2021

Background: MYCN amplification (MNA), segmental chromosomal aberrations (SCA) and ALK activating mutations are biomarkers for risk-group stratification and for targeted therapeutics for neuroblastoma, both of which are currently assessed on tissue biopsy. Increase in demand for tumor genetic testing for neuroblastoma diagnosis is posing a challenge to current practice, as the small size of the core needle biopsies obtained are required for multiple molecular tests. We evaluated the utility of detecting these biomarkers in the circulation. Methods: Various pre-analytical conditions tested to optimize circulating-tumor DNA (ctDNA) copy number changes evaluations. Plasma samples from 10 patients diagnosed with neuroblastoma assessed for SCA and MNA using single nucleotide polymorphism (SNP) array approach currently used for neuroblastoma diagnosis, with MNA status assessed independently using digital-droplet PCR (ddPCR). Three patients (one in common with the previous 10) tested for ALK activating mutations p.F1174L and p.F1245I using ddPCR. Results: Copy number detection is highly affected by physical perturbations of the blood sample (mimicking suboptimal sample shipment), which could be overcome using specialized preservative collection tubes. Pre-analytical DNA repair procedures on ctDNA before SNP chromosome microarray processing improved the lower limit of detection for SCA and MNA, defined as 20% and 10%, respectively. We detected SCA in 10/10 (100%) patients using SNP array, 7 of which also presented MNA. Circulating-free DNA (cfDNA) and matched tumor DNA profiles were generally identical. MNA was detected using ddPCR in 7/7 (100%) of MNA and 0/12 (0%) non-MNA cases. MNA and ALK mutation dynamic change was assessed in longitudinal samples from 4 and 3 patients (one patient with both), respectively, accurately reflected response to treatment in 6/6 (100%) and disease recurrence in 5/6 (83%) of cases. Samples taken prior to targeted treatment with the ALK inhibitor Lorlatinib and 6–8 weeks on treatment showed reduction/increase in ALK variants according to response to treatment. Conclusions: These results demonstrate the feasibility of ctDNA profiling for molecular risk-stratification, and treatment monitoring in a clinically relevant time frame and the potential to reduce fresh tissue requirements currently embedded in the management of neuroblastoma.
The Monitoring of Black-Odor River by Electronic Nose with Chemometrics for pH, COD, TN, and TP
Authors: Qiu Shanshan , Hou Pingzhi , Huang Jingang , Han Wei , Kang Zhiwei
Published: July 2021

Black-odor rivers are polluted urban rivers that often are black in color and emit a foul odor. They are a severe problem in aquatic systems because they can negatively impact the living conditions of residents and the functioning of ecosystems and local economies. Therefore, it is crucial to identify ways to mitigate the water quality parameters that characterize black-odor rivers. In this study, we tested the efficacy of an electronic nose (E-nose), which was inexpensive, fast, and easy to operate, for qualitative recognition analysis and quantitative parameter prediction of samples collected from the Yueliang River in Huzhou City. The E-nose sensors were cross-sensitive to the volatile compounds in black-odor water. The device recognized the samples from different river sites with 100% accuracy based on linear discriminant analysis. For water quality parameter predictions, partial least squares regression models based on E-nose signals were established, and the coefficients between the actual water quality parameters (pH, chemical oxygen demand, total nitrogen content, and total phosphorous content) and the predicted values were very high (R2 > 0.90) both in the training and testing sets. These results indicate that E-nose technology can be a fast, easy-to-build, and cost-effective detection system for black-odor river monitoring.
Two Antibiotics, Ampicillin and Tetracycline, Exert Different Effects in HT-29 Colorectal Adenocarcinoma Cells in Terms of Cell Viability and Migration Capacity
Authors: Hut Emil-Florin , Radulescu Matilda , Pilut Nicolae , Macasoi Ioana , Berceanu Delia , Coricovac Dorina , Pinzaru Iulia , Cretu Octavian , Dehelean Cristina
Published: July 2021

Antibiotics are considered the cornerstone of modern medicine; however, currently, antibiotic resistance has become a global health issue. Antibiotics also find new uses in the treatment of other pathologies as well as cancer. The present study aimed to verify the impact of tetracycline and ampicillin in a colorectal adenocarcinoma cell line, HT-29. The effects of the two antibiotics on cell viability and nucleus were evaluated by the means of MTT assay and the Hoechst staining method, respectively. The irritant potential at vascular level of the chorioallantoic membrane was tested by the HET-CAM assay. Treatment of HT-29 cells with the two antibiotics determined different effects: (i) tetracycline induced a dose- and time-dependent cytotoxic effect characterized by decreased cell viability, changes in cells morphology, apoptotic features (nuclear fragmentation), and inhibition of cellular migration, whereas (ii) ampicillin exerted a biphasic response—cytotoxic at low doses and proliferative at high concentrations. In terms of effect on blood vessels, both antibiotics exerted a mild irritant effect. These results are promising and could be considered as starting point for further in vitro studies to define the molecular mechanisms involved in the cytotoxic/proliferative effects.
A Wolf in Sheep’s Clothing: Collision of Melanoma and Keratoacanthoma
Authors: Walther Matthias , Falkvoll Sandra , Leibl Sebastian
Published: July 2021

Collision tumors consisting of melanoma and squamous cell carcinoma are very rare. We present the case of a deceptive hyperkeratotic nodule on the forearm of a 72-year-old woman, which clinically appeared to be a squamous cell carcinoma, keratoacanthoma type. Histological examination surprisingly revealed a coexisting epithelioid melanoma. Thus, this case report shows the importance of an early histopathological and immunohistochemical workup to prevent unnecessary diagnostic and therapeutic delay with negative effects on prognosis.
Improved Effort and Cost Estimation Model Using Artificial Neural Networks and Taguchi Method with Different Activation Functions
Authors: Rankovic Nevena , Rankovic Dragica , Ivanovic Mirjana , Lazic Ljubomir
Published: July 2021

Software estimation involves meeting a huge number of different requirements, such as resource allocation, cost estimation, effort estimation, time estimation, and the changing demands of software product customers. Numerous estimation models try to solve these problems. In our experiment, a clustering method of input values to mitigate the heterogeneous nature of selected projects was used. Additionally, homogeneity of the data was achieved with the fuzzification method, and we proposed two different activation functions inside a hidden layer, during the construction of artificial neural networks (ANNs). In this research, we present an experiment that uses two different architectures of ANNs, based on Taguchi’s orthogonal vector plans, to satisfy the set conditions, with additional methods and criteria for validation of the proposed model, in this approach. The aim of this paper is the comparative analysis of the obtained results of mean magnitude relative error (MMRE) values. At the same time, our goal is also to find a relatively simple architecture that minimizes the error value while covering a wide range of different software projects. For this purpose, six different datasets are divided into four chosen clusters. The obtained results show that the estimation of diverse projects by dividing them into clusters can contribute to an efficient, reliable, and accurate software product assessment. The contribution of this paper is in the discovered solution that enables the execution of a small number of iterations, which reduces the execution time and achieves the minimum error.
Impact of Imbalance Pricing on Variable Renewable Energies with Different Prediction Accuracies: A Korean Case
Authors: Moon Heeseung , Lee Dongsu , Han Jeongmin , Yoon Yongtae , Kim Seungwan
Published: July 2021

Although the Korean government plans to increase its share of variable renewable energies (VREs), the Korean power market is not sufficiently mature to accommodate a large increase in VRE generation. Thus, the Korean system operator plans to introduce a two-settlement, and an imbalance settlement is also under consideration, among several options. Therefore, this study analyzes how many incentives are given for prediction accuracy under several imbalance settlement schemes adopted from European and US power markets. Results show that the imbalance settlement consisting of threshold and penalty terms is useful for rule-makers, who can control revenue differences between the groups with different prediction accuracies by adjusting the two terms. The suggestion given in the paper will be useful for not only the Korean power market but also for the countries that plan to establish the imbalance settlement rules while increasing renewable energy.
Optimum Railway Transition Curves—Method of the Assessment and Results
Authors: Zboinski Krzysztof , Woznica Piotr
Published: July 2021

This article discusses the optimization of railway transition curves, through the application of polynomials of 9th and 11th degrees. In this work, the authors use a 2-axle rail vehicle model combined with mathematically understood optimization methods. This model is used to simulate rail vehicle movement negotiating both a transition curve and circular arc. Passenger comfort is applied as the criterion to assess which transition is actually is the best one. The 4-axle vehicle was also used to verify the results obtained using the 2-axle vehicle. Our results show that the traditionally used in a railway engineering transition—3rd degree parabola—which is not always the optimum curve. This fact is especially valid for the longest curves, with lengths greater than 150 m. For such cases, the transition curves similar to standard curves of 9th and 11th degrees is the optimum ones. This result is confirmed by the use of the 4-axle vehicle.
Land-Use Change and Bioenergy Production: Soil Consumption and Characterization of Anaerobic Digestion Plants
Authors: Ferrari Giovanni , Ioverno Federico , Sozzi Marco , Marinello Francesco , Pezzuolo Andrea
Published: July 2021

The exploitation of bioenergy plays a key role in the process of decarbonising the economic system. Huge efforts have been made to develop bioenergy and other renewable energy systems, but it is necessary to investigate the costs and problems associated with these technologies. Soil consumption and, in particular, soil sealing are some of these aspects that should be carefully evaluated. Agricultural biogas plants (ABPs) often remove areas dedicated to agricultural activities and require broad paved areas for the associated facilities. This study aimed to (i) assess the surfaces destined to become facilities and buildings in ABPs, (ii) correlate these surfaces with each other and to the installed powers of the plants, and (iii) estimate the consumption of soil in bioenergy applications in Italy. Two hundred ABPs were sampled from an overall population of 1939, and the extents of the facilities were measured by aerial and satellite observations. An ABP with an installed power of 1000 kW covers an average surface area of up to 23,576 m2. Most of this surface, 97.9%, is obtained from previously cultivated areas. The ABP analysis proved that 24.7 m2 of surface area produces 1 kW of power by bioenergy. The obtained model estimated a total consumption of soil by ABPs in Italy of 31,761,235 m2. This research can support stakeholders in cost-benefit analyses to design energy systems based on renewable energy sources.
On the Optimisation of Urban form Design, Energy Consumption and Outdoor Thermal Comfort Using a Parametric Workflow in a Hot Arid Zone
Authors: Ibrahim Yasser , Kershaw Tristan , Shepherd Paul , Coley David
Published: July 2021

The recent reports from the Intergovernmental Panel on Climate Change (IPCC) urge for the reconceptualization of our design of the urban built environments. However, current efforts to integrate urban environmental assessment into practice in Egypt are proving insufficient. This paper utilises the Ladybug tools simulation plugins to investigate the impact of changing the morphological characteristics of three-block typologies (scattered, linear and courtyard) and their associated parameters to understand their multidimensional relationship with environmental conditions, outdoor thermal comfort and energy use intensity. This study based in Cairo, Egypt, considers 3430 hypothetical geometrical configurations comprising of a variety of design parameters and indicators. The results show a strong correlation between the design parameters and the combined performance of thermal comfort and energy consumption (R2 = 0.84), with urban density having the strongest impact on both thermal comfort and energy use (R2 = 0.7 and 0.95, respectively). The design parameters exhibited a consistent impact on the different typologies, albeit with varying magnitude. Compact and medium-density urban forms are shown to elicit the best overall performance, especially for ordinal orientations (e.g., ~45°) across all typologies. Compact high-density scattered forms are favoured when considering thermal comfort, while courtyards outperform other typologies when considering energy efficiency and overall performance.
Seismic Performance of Piping Systems of Isolated Nuclear Power Plants Determined by Numerical Considerations
Authors: Chang Sungjin , Jeon Bubgyu , Kwag Shinyoung , Hahm Daegi , Eem Seunghyun
Published: July 2021

The interest in the seismic performance of nuclear power plants has increased worldwide since the Fukushima Daiichi Nuclear Power Plant incident. In Korea, interest in the seismic safety of nuclear power plants has increased since the earthquake events in Gyeongju (2016) and Pohang (2017). In Korea, studies have been conducted to apply seismic isolation systems to ensure seismic safety while minimizing the design changes to nuclear power plants. Nuclear power plants with seismic isolation systems may have a higher seismic risk due to the failure of the piping system in the structure after a relatively large displacement. Therefore, it is essential to secure the seismic safety of pipes for the safe operation of nuclear power plants. The seismic safety of pipes is determined by seismic fragility analysis. Seismic fragility analysis requires many seismic response analyses because it is a statistical approach to various random variables. Typical numerical conditions affecting the seismic response analysis of pipes are the convergence conditions and mesh size in numerical analysis. This study examined the change in the seismic safety of piping according to the numerical conditions. The difference in the seismic response analysis results of the piping according to the mesh size was analyzed comparatively. In addition, the change in the seismic fragility curve of the piping according to the convergence conditions was investigated.
Hydrogen Dispersion and Ventilation Effects in Enclosures under Different Release Conditions
Authors: Brzezińska Dorota
Published: July 2021

Hydrogen is an explosive gas, which could create extremely hazardous conditions when released into an enclosure. Full-scale experiments of hydrogen release and dispersion in the confined space were conducted. The experiments were performed for hydrogen release outflow of 63 × 10−3 m3/s through a single nozzle and multi-point release way optionally. It was found that the hydrogen dispersion in an enclosure strongly depends on the gas release way. Significantly higher hydrogen stratification is observed in a single nozzle release than in the case of the multi-point release when the gas concentration becomes more uniform in the entire enclosure volume. The experimental results were confirmed on the basis of Froud number analysis. The CFD simulations realized with the FDS code by NIST allowed visualization of the experimental hydrogen dispersion phenomenon and confirmed that the varied distribution of hydrogen did not affect the effectiveness of the accidental mechanical ventilation system applied in the tested room.
The Role of Agriculture and Rural Areas in the Development of Autonomous Energy Regions in Poland
Authors: Ślusarz Grzegorz , Gołębiewska Barbara , Cierpiał-Wolan Marek , Twaróg Dariusz , Gołębiewski Jarosław , Wójcik Sebastian
Published: July 2021

In many countries, energy security is treated as a priority for the coming decades, and at the same time energy production from the vast majority conventional energy sources does not meet environmental protection criteria. Hence, the need to use renewable energy sources (RES), which can largely satisfy energy needs. The aim of the study was to identify possibilities of creating autonomous energy regions (ARE) in Poland, based on renewable energy sources. Attention was paid to the role and significance of the potential of rural areas in this respect, taking into account the possibilities of increasing energy production from these sources in individual regions of Poland. The research was conducted on a regional level (division into voivodships) and on a local level (division into powiats, which form voivodships). When assessing the potential for constructing ARE based on RES, the following energy sources were taken into account: water, wind, sun, biogas and biomass. It was found that the highest RES potential versus energy consumption can be obtained in powiats where the share of arable land and forests exceeds 80%. The research showed that in most regions of Poland (powiats, voivodships), there is a large potential for obtaining additional energy from RES, which would cover over 73% of the country’s demand for electricity. This could be the basis for building energy independence on a local scale. The results of the study indicated that as many as seven regions would become self-sufficient in terms of electricity demand.
Ethanol/Gasoline Blends as Alternative Fuel in Last Generation Spark-Ignition Engines: A Review on CO and HC Engine Out Emissions
Authors: Iodice Paolo , Cardone Massimo
Published: July 2021

Among the alternative fuels existing for spark-ignition engines, ethanol is considered worldwide as an important renewable fuel when mixed with pure gasoline because of its favorable physicochemical properties. An in-depth and updated investigation on the issue of CO and HC engine out emissions related to use of ethanol/gasoline fuels in spark-ignition engines is therefore necessary. Starting from our experimental studies on engine out emissions of a last generation spark-ignition engine fueled with ethanol/gasoline fuels, the aim of this new investigation is to offer a complete literature review on the present state of ethanol combustion in last generation spark-ignition engines under real working conditions to clarify the possible change in CO and HC emissions. In the first section of this paper, a comparison between physicochemical properties of ethanol and gasoline is examined to assess the practicability of using ethanol as an alternative fuel for spark-ignition engines and to investigate the effect on engine out emissions and combustion efficiency. In the next section, this article focuses on the impact of ethanol/gasoline fuels on CO and HC formation. Many studies related to combustion characteristics and exhaust emissions in spark-ignition engines fueled with ethanol/gasoline fuels are thus discussed in detail. Most of these experimental investigations conclude that the addition of ethanol with gasoline fuel mixtures can really decrease the CO and HC exhaust emissions of last generation spark-ignition engines in several operating conditions.
Multi-Wire Interconnection of Busbarless Solar Cells with Embedded Electrode Sheet
Authors: Park Jeong Eun , Choi Won Seok , Lim Dong Gun
Published: July 2021

The module technology proposed in this paper is used to fabricate a wire embedded ethyl vinyl acetate (EVA) sheet module by applying a cell/module integrated process in which the cell and wire are bonded during the lamination process. A wire-embedded EVA sheet module was fabricated using a busbarless cell and SnBiAg wire. As a result of the module characteristics corresponding to the lamination process temperature, the highest efficiency of 19.55% was observed at 170 °C. The lowest contact resistivity between the wire and the finger electrode was shown under a temperature condition of 170 °C, which was confirmed to increase the efficiency owing to an improvement of the fill factor with an excellent electrical contact.
Reactivity Effect Evaluation of Fast Reactor Based on Angular-Dependent Few-Group Cross Sections Generation
Authors: Du Xianan , Wu Xuewen , Zheng Youqi , Wang Yongping
Published: July 2021

Among all the possible occurring reactivity effects of a fast reactor, the situations whereby the control rod was inserted, or the coolant was voided could lead to strong anisotropy of neutron flux distribution, therefore the angular dependence on neutron flux should be considered during the few-group cross-sections generation. Therefore, the purpose of this paper is to compare the influence whether the angular dependence on neutron flux is considered in the calculation of few-group cross sections for the reactivity effect calculation. In the study, the 1-D SN finite difference neutron transport equation solver was implemented in the TULIP of SARAX code system so that the high-order neutron flux could be obtained. Meanwhile, the improved Tone’s method was also applied. The numerical results were obtained based on three experimental FR cores, the JOYO MK-I core, ZPPR-9 core, and ZPPR-10B core. Both control rod worth and sodium void reactivity were calculated and compared with the measurement data. By summarizing and comparing the results of 46 cases, significant differences were found between different consideration of the neutronic analysis. The consideration of angular dependence on neutron flux distribution in the few-group cross-sections generation was beneficial to the neutronic design analysis of FR, especially for the reactivity effect calculation.
The Relationship between Peer Attachment and Aggressive Behavior among Chinese Adolescents: The Mediating Effect of Regulatory Emotional Self-Efficacy
Authors: Liu Haitao , Dou Kai , Yu Chengfu , Nie Yangang , Zheng Xue
Published: July 2021

This study aimed to test the association between peer attachment and aggressive behavior, as well as the mediating effect of regulatory emotional self-efficacy on this relationship. A total of 1171 (582 male, 589 female) Chinese adolescents completed self-reported questionnaires that assessed peer attachment, regulatory emotional self-efficacy, and aggressive behavior. Path analysis showed that the negative association between peer attachment and adolescent aggressive behavior was mediated by self-efficacy in managing negative emotions. However, the mediating effect of self-efficacy in expressing positive emotions was nonsignificant. Moreover, there was no significant difference in the indirect paths mentioned above between male and female respondents. These findings highlight self-efficacy in managing negative emotions as a potential mechanism linking peer attachment to adolescent aggressive behavior.
The Role of Frailty in Predicting 3 and 6 Months Functional Decline in Hospitalized Older Adults: Findings from a Secondary Analysis
Authors: Tavares João , Sa-Couto Pedro , Reis João Duarte , Boltz Marie , Capezuti Elizabeth
Published: July 2021

Frailty represents one of the most relevant geriatric syndromes in the 21st century and is a predictor of adverse outcomes in hospitalized older adult, such as, functional decline (FD). This study aimed to examine if frailty, evaluated with the Frailty Index (FI), can predict FD during and after hospitalization (3 and 6 months). Secondary data analysis of a prospective cohort study of 101 hospitalized older adults was performed. The primary outcome was FD at discharge, 3 and 6 months. The FI was created from an original database using 40 health deficits. Functional decline models for each time-point were examined using a binary logistic regression. The prevalence of frailty was 57.4% with an average score of 0.25 (±0.11). Frail patients had significant and higher values for functional decline and social support for all time periods and more hospital readmission in the 3 month period. Multivariable regression analysis showed that FI was a predictor of functional decline at discharge (OR = 1.07, 95% CI = 1.02–1.14) and 3-month (OR = 1.05, 95% CI = 1.01–1.09) but not 6-month (OR = 1.03, 95% CI = 0.99–1.09) follow-up. Findings suggest that frailty at admission of hospitalized older adults can predict functional decline at discharge and 3 months post-discharge.
Measuring Responses of Dicyandiamide-, 3,4-Dimethylpyrazole Phosphate-, and Allylthiourea-Induced Nitrification Inhibition to Soil Abiotic and Biotic Factors
Authors: Lin Yu-Pin , Ansari Andrianto , Cheng Lien-Chieh , Lin Chiao-Ming , Wunderlich Rainer-Ferdinand , Cao Thanh-Ngoc-Dan , Mukhtar Hussnain
Published: July 2021

Nitrification inhibitors (NIs) such as dicyandiamide (DCD), 3,4-dimethylpyrazole phosphate (DMPP), and allylthiourea (AT) are commonly used to suppress ammonia oxidization at different time scales varying from a few hours to several months. Although the responses of NIs to edaphic and temperature conditions have been studied, the influence of the aforementioned factors on their inhibitory effect remains unknown. In this study, laboratory-scale experiments were conducted to assess the short-term (24 h) influence of eight abiotic and biotic factors on the inhibitory effects of DCD, DMPP, and AT across six cropped and non-cropped soils at two temperature conditions with three covariates of soil texture. Simultaneously, the dominant contributions of ammonia-oxidizing archaea (AOA) and bacteria (AOB) to potential ammonia oxidization (PAO) were distinguished using the specific inhibitor 2 phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO). Our results revealed that AT demonstrated a considerably greater inhibitory effect (up to 94.9% for an application rate of 75 mg of NI/kg of dry soil) than DCD and DMPP. The inhibitory effect of AT was considerably affected by the relative proportions of silt, sand, and clay in the soil and total PAO. In contrast to previous studies, the inhibitory effects of all three NIs remained largely unaffected by the landcover type and temperature conditions for the incubation period of 24 h. Furthermore, the efficacy of all three tested NIs was not affected by the differential contributions of AOA and AOB to PAO. Collectively, our results suggested a limited influence of temperature on the inhibitory effects of all three NIs but a moderate dependence of AT on the soil texture and PAO. Our findings can enhance the estimation of the inhibitory effect in soil, and pure cultures targeting the AOA and AOB supported ammonia oxidization and, hence, nitrogen dynamics under NI applications.