bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of Intranasal Dexmedetomidine as a Preoperative Anxiolytic in Children: A Systematic Review
Authors: Wood, MSNA, CRNA Eric R.
Published: August 2024

Preoperative anxiety is a common problem in pediatric patients that can have many negative effects; oral premedications (eg, midazolam) are often used to reduce anxiety and improve compliance. Dexmedetomidine (DEX) is an alpha-2 receptor agonist that can be given intranasally to children as a premedication and may be useful as an anxiolytic. In this systematic review of the PubMed, CINAHL, Ovid, and Cochrane Library databases, the efficacy of intranasal dexmedetomidine (IN DEX) was compared with that of oral midazolam for relieving preoperative anxiety among pediatric surgical patients. Three trials were assessed: 2 of these trials concluded that IN DEX was a superior anxiolytic for use in children; the third showed that there was no significant difference. More rigorous research that includes a larger sample size and an objective measurement tool is needed before drawing conclusions.
How is Intraoperative Music Therapy Beneficial to Adult Patients Undergoing General Anesthesia? A Systematic Review
Authors: Flanagan, MSN, CRNA, DNPc Donté A. , Kerin, MS, CRNA Athena
Published: August 2024

Today’s expanding role of technology and the internet-of-things has become an integral aspect of the treatment modalities of health care providers throughout health care systems. With the advent of new devices and online music services, every genre of music is merely a finger touch away for each and every patient. Music therapy has been accepted as a beneficial tool used for the treatment of anxiety and pain relief for the conscious patient. Research has also been conducted to examine the analgesic benefits of music therapy on the patient undergoing general anesthesia. This systematic review focused on answering the aforementioned question regarding the added effects of music therapy. After thorough examination of the literature, it was concluded that the incorporation of volume-protective headphones and patient-chosen music therapy can be an effective and inexpensive intervention during general anesthesia with statistically significant results for decreased pain, decreased opioid needs, and increased patient satisfaction.
 
INTRODUCTION
The use of music for the treatment of disease processes and ailments can be traced back for millennia. Light et al1 found evidence of the use of music for medical treatment as far back as 2500 BC. For centuries, the benefits were observational at best, but music remained as an acceptable adjunct therapy for patients in the health care arena. In English hospitals in the 19th century, musicians were hired to play for sick patients.1 Physicians and scientists began to study the effects on physiology and the benefits of music at the turn of the 20th century. It was then that physicians across the world began to record the changes caused by music on vital signs. Farr1 pioneered the idea of music in operation suites as early as 1929. In the late 1940s, Pickrell and his research team spent 6 years studying the effects of music therapy on preoperative, intraoperative, and postoperative surgical patients.2 Their research findings suggest that patients experience decreased fear and apprehension when music is an added element of the surgical experience. Pickrell et al2 also noted the use of headphones to be beneficial, not only for delivering the intervention but also as a tool for blocking out nonreassuring noise and conversation inside the surgical arena. Theses surgeries were exclusively performed on sedated patients receiving local, spinal, or regional anesthesia. Systematic reviews to date have included regional anesthesia (ie, epidural, spinal, and local anesthesia), monitored anesthesia care, and general anesthesia3; however, the present systematic review focused only on those interventions done under general anesthesia.
Congenital Long QT Syndrome:
Authors: Harris David E
Published: August 2024

Context: Congenital long QT syndrome (cLQTS) is the most common genetic cardiac ion channelopathy in the US. Patients with cLQTS are at risk for ventricular tachycardia (VT) in the “torsades de pointes” (TdP) pattern from physical and emotional stress, including during the perioperative period.
Purpose: This narrative review outlines the history and pathophysiology of the most common types of cLQTS, describes treatments for cLQTS, discusses the experience of anesthesia providers with cLQTS, and reports recommendations for safe administration of anesthesia to these patients.
Methods: Searches of MEDLINE (PubMed) and Google Scholar were conducted using the terms “congenital long QT syndrome”, “LQTS”, and “cardiac ion channelopathy” combined with “surgery” and “anesthesia”.
Findings: The most common types of cLQTS (LQT1-3) are caused by loss of function mutations to potassium channels responsible for ventricular repolarization or gain of function mutations to a sodium channel responsible for depolarization. cLQTS is diagnosed using the Schwartz Criteria which considers ECG findings, clinical history, and family history. It is treated with beta blocking medication, implantable cardioverter defibrillator (ICD) insertion, or left cardiac sympathetic denervation (LCSD).  Patients with cLQTS may require anesthesia for disease-related procedures (e.g. ICD insertion or LCSD), or for treatment of issues related to cLQTS (e.g. cochlear implants for congenital sensorineural deafness). To provide a safe anesthetic, providers need to avoid medications that prolong the QTc, minimize sympathetic stimulation, assure proper function of but prevent electrical interference with ICDs, correct electrolyte imbalances, and be prepared to treat TdP. 
Importance: Pre-anesthetic precautions include considering a cardiologist consultation, checking the function of the ICD, determining a baseline QTc, correcting electrolyte imbalances, premedicating to prevent anxiety, and continuing beta blocking medications on the day of surgery. Intraoperative, the anesthesia provider should apply external defibrillator pads and all monitors prior to induction, turn off ICD or adjust its settings to avoid electromagnetic interference, monitor the QT interval, have magnesium salts ready if TdP develops, consider TIVA and use sevoflurane if an inhalation agent is needed, use propofol and/or fentanyl (or an analogue) to blunt the sympathetic response of airway manipulation, and avoid ketamine, suxamethonium, and pancuronium. During emergence, the provider should consider alternatives to anticholinesterase/ anticholinergic drug combinations, avoid droperidol or ondansetron, but consider dexamethasone as prophylaxis against PONV.
Limitations: Because there are no definitive guidelines for the anesthetic management of patients with cLQTS, the anesthesia provider must rely on case studies and review articles to choose a safe anesthetic for this challenging patient population.
Chronique piscicole : troisième colloque sur l’hydrobiologie et les pêches en eau douce en Afrique
Authors: Lemasson J.
Published: August 2024

Pas de résumé
The Role of Students in Islamic Politics: Challenges and Opportunities in the Era of Modernisation
Authors: Aditya Aditya Purnadani , Fahrudin Fahrudin , Jaenuri Jaenuri
Published: August 2024

Students have a role as agents of change as activists for the country, students who are faced with various challenges in this modernisation era have many challenges and also increasingly complex demands.  The development of technology has a big impact at this time. Students continue to strive to overcome problems in the development of this nation. In our country, students play many roles in the political world including (1) Awareness of politics and education, (2) Advocacy of social justice, and (3) Moral guardians in the political world. However, students are still faced with various challenges in this global era related to their status as Muslim intellectuals. The challenge is the lack of understanding from the Muslim community about the principles of Islam.
KAROTİD ARTER STENTLEME YAPILAN HASTALARDA KLOPİDOGREL DİRENCİ VE ETKİLEYEN FAKTÖRLERİN DEĞERLENDİRİLMESİ
Authors: İyigündoğdu İlkin , Şahin Bengisu , Derle Eda , Can Ufuk
Published: August 2024

Amaç:
Karotid arter stentleme yapılan hastalarda peri ve postprosedüral süreçte trombotik komplikasyon riskini azaltmak amacıyla antiaggregan ilaçlar kullanılmaktadır. Hasta tedavi uyumuna rağmen amaçlanan tedavi etkisine ulaşılamayabilir ve bu durum sıklıkla antiagregan direnci ile ilişkilendirilir. Bu çalışmada, karotid arter stentleme yapılan hastalarda klopidogrel direnç sıklığı ve dirençle ilişkili olabilecek risk faktörlerinin belirlenmesi amaçlanmıştır.
Gereç ve Yöntem:
Çalışmada Başkent Üniversitesi Hastanesi’nde 2011-2023 yılları arasında nöroloji klinik yada polikliniklerinde karotid arter stentleme ile takip edilen hastaların verileri retrospektif olarak değerlendirildi. Düzensiz ilaç kullanımı olanlar çalışma dışı bırakıldı. Hastaların demografik özellikleri, aterosklerotik risk faktörleri, semptomları kaydedildi. Takip süreleri, periprosedüral süreçte görülen komplikasyonlar, takip restenoz, işlem sonrası serebrovasküler hastalık ve mortalite oranları saptandı. Stentleme yapılan taraf, darlık derecesi, kontralateral darlık varlığı kaydedildi. Kullanılan antiagregan ilaçlar, kullanım doz ve süreleri, klopidogrel direnç test sonuçları ve test zamanları kaydedildi. Direnç sıklığı ile demografik özellikler, komorbid durumlar, kullanılan ilaçlar ve kan tetkik sonuçları arasında ilişki olup olmadığı araştırıldı. Veriler SPSS paket programı ile analiz edildi. p< 0.05 istatiksel anlamlılık düzeyi olarak kabul edildi.
Bulgular:
Toplam 138 hastanın yaş ortalamaları 68.91±8,66 yıldı ve %71.7’si erkek cinsiyetindeydi. Hastaların %52.2’ sinde sağ karotid arter darlığı bulunmaktaydı. Darlık dereceleri değerlendirildiğinde, 65 hastada (%47.1) ≥ %90 darlık saptandı. 103 hastada (%74.6) semptomatik karotid arter darlığı nedeniyle işlem planlanmıştı. 87 hastada (%63.3) ADP testi yapılmıştı. Klopidogrel kullanan hastaların %17.2’sinde ilaç direnci gözlendi. Klopidogrel direnci kadın hastalarda erkeklere oranla istatiksel olarak anlamlı oranda yüksek saptandı (p
Preparedness of lecturers in integrating gender responsiveness in the curriculum in community colleges in the Eastern Cape
Authors: Tawana X , Higgs P
Published: August 2024

This article sets out to explore the problem of the preparedness of lecturers in integrating a gender responsive curriculum in Community Colleges the Eastern Cape. It is essential to understand why lecturers do not incorporate a gender responsive curriculum to help Community Colleges in the Eastern Cape develop fresh approaches that will directly address the specific requirements of both males and females. This article adopts a phenomenological research design to determine lecturer’s perceptions and perspectives on how well as they considered themselves ready in ensuring a gender responsive curriculum in the Community Colleges in the Eastern Cape. The methodology considered to be most suitable for grounding this study was a critical research methodology because approaches like positivism and interpretivism do not challenge inferences to increase the value of evidence collected on the ground. The required research data were gathered using semi-structured interview on eight (8) lecturers who volunteered to participate in this study. The research findings revealed that lecturers are not prepared to ensure a gender responsive curriculum in Community Colleges in the Eastern Cape. Their viewpoints therefore suggested that preparedness for the integration of a gender responsive curriculum is essential in Community Colleges.
Relasi Hukum dan Kekuasaan Analisis Pemikiran Nonet Selznick
Authors: Dermawan Doni , Yaswirman Yaswirman , Eva Yusnita
Published: August 2024

Hubungan hukum dan kekuasaan merupakan setali mata uang dalam konstelasi bernegara. Untuk mengetahui bagaimana tipe hubungan hukum dan kekuasaan tersebut, Nonet dan Selznick telah mengemukakan teori tipologi karakter hubungan hukum dan kekuasaan. Dari teori yang dikemukakan oleh Nonet dan Selznick ini dapat diketahui bagaimana sebenarnya relasi hukum dan negara tersebut. Tulisan ini mencoba menjawab persoalan bagaimanakah tipologi relasi hukum dan kekuasaan yang sesuai untuk diterapkan disebuah negara. Tujuan dari dibuatnya kajian ini adalah untuk mengetahui bagaimana tipologi relasi hukum dan kekuasaan yang sesuai untuk diterapkan berdasarkan kepada pemikiran Nonet dan Selznick. Untuk menjawab persoalan yang diajukan, penulis menggunakan metode penelitian diskriptif dengan jenis penelitian kepustakaan. Berdasarkan pemahaman terhadap pemikiran Nonet dan Selznick, tipologi  hukum dalam repressive law, autonomous law dan responsive law sangat berkaitan dengan tipe masyarakatnya. Oleh karena itu sulit untuk mengatakan bahwa penguasa dapat menggunakan repressive law, autonomous law dan responsive law dalam satu waktu yang sama.
FACTORS AFFECTING ECONOMIC GROWTH IN EAST JAVA PROVINCE IN 2011 – 2020
Authors: Hubaidillah Ahmad , Soelityo Aris , Kusuma Hendra
Published: August 2024

This study aims to examine the analysis of the effect of general allocation funds, regional taxes, and population on economic growth in East Java Province from 2011 to 2020. Tax reforms mandated by Law number 28 of 2009 have encouraged local governments to increase equity among regions to reduce regional inequality. The variables used include general allocation funds, local taxes, and total population. Using multiple regression analysis with panel data regression for five samples of districts/cities in East Java Province, the results show that General Allocation Fund (DAU) has a positive and significant infliuence on the economic growth rate. Meanwhile Regional tax and Population has a negative and significant infliuence on the economic growth rate. As much as 92% of the economic growth variable can be explained by the general allocation fund (DAU), the regional tax, and the population.
DYNAMIC BEHAVIOR OF RUPIAH EXCHANGE RATE PERIOD 1999Q1-2020Q2 (STICKY PRICE MODEL KEYNESIAN APPROACH)
Authors: Wijaya Erric
Published: August 2024

This study investigates the dynamic behavior of the Indonesian Rupiah (IDR) exchange rate against the US Dollar (USD) from the first quarter of 1999 to the second quarter of 2020. The primary objective is to assess the factors influencing exchange rate fluctuations using time-series data analyzed through multiple linear regression. The study focuses on key macroeconomic variables, including the M2 money supply ratio, inflation ratio, GDP ratio, and interest rate ratio, to determine their impact on the IDR/USD exchange rate. The findings reveal that the M2 ratio, inflation ratio, and GDP ratio significantly and positively influence the IDR/USD exchange rate, indicating that increases in these variables lead to a depreciation of the Rupiah. However, the interest rate ratio does not exhibit a significant effect on the exchange rate. The model demonstrates a high degree of fit with an adjusted R2 value of 94.42%, and the overall model is statistically significant, as indicated by the F-statistic probability of 0.000. These results provide valuable insights into the determinants of exchange rate movements in Indonesia during the specified period.
MOUNTAIN LANDSCAPE WITH REGIONAL ARCHITECTURE IN THE CREATIVE ACTIVITY OF WAŁBRZYCH ARTISTS UNTIL 1945
Authors:   Wydział Architektury PWr, Poland, Suchodolski Jacek
Published: August 2024

The article analyzes the regional architecture in the creative activity of Wałbrzych artists until 1945.The study identifies an association of painters and people whose creative activity was connected with the mountain surroundings and landscape. The goal is to present and discuss the relatively little-known artistic activity, which were connected with the historic activity, which were connected with the historic wooden architecture found in this mountain landscape, constituted its significant part. Also, the currently non-existing specific landscape of the highly industrialized region in combination with wooden buildings against a background of mountain ranges, became an inspiration to address this issue.
IMPLEMENTATION OF DESIGN STRATEGIES SUPPORTING THE AVAILABILITY OF TYPHLOGRAPHIC STUDIES. CASE STUDY – SERIES OF TYFLOPLANS IN PUBLIC UTILITIES FACILITIES IN BIAŁYSTOK
Authors:   Bialystok University of Technology, Poland Faculty of Architecture, Duniewicz Agnieszka
Published: August 2024

The article presents a report on research encompassing four series of tactile maps (typhlographs), showcased in prominent institutions in Białystok. The research aimed to identify and evaluate design strategies pertaining to accessibility for individuals with visual impairments. The on-site acquired research material underwent analysis, leading to the development of collection characteristics. Subsequently, elements of design strategies were scrutinized and validated for typhlological correctness. The research outcome comprises a summary of appropriate design principles (enhancing typhological accessibility) and inadequate solutions (diminishing the efficacy of such assistance), delineated across four selected domains.
Intrusion Detection Using Machine Learning and Deep Learning Models on Cyber Security Attacks
Authors: Khan Irfanullah , Junaid Khan  , Bangash Shah Hussain , Waqas Ahmad  , Khan Asad Iftikhar , Hameed Khalid
Published: August 2024

To detect and stop harmful activity in computer networks, network intrusion detection is an essential part of cybersecurity defensive systems. It is becoming more difficult for traditional rule-based techniques to identify new attack vectors in the face of the increasing complexity and diversity of cyber threats. Machine learning (ML) and deep learning (DL) models can analyze vast amounts of network traffic data and automatically identify patterns and anomalies, there has been a surge in interest in using these models for network intrusion detection. This paper examines the approaches, algorithms, and real-world applications of machine learning and deep learning techniques for network intrusion detection in order to present a thorough review of the state-of-the-art in countering cyber threats. We assess ML and DL-based intrusion detection systems' effectiveness, strengths, and weaknesses in a range of attack scenarios and network environments by synthesizing current literature and empirical research. Additionally, we talk about new developments, obstacles, and paths forward in the areas of transfer learning, adversarial robustness, and ensemble learning. The understanding gained from this investigation clarifies the potential of ML and DL models in strengthening defenses against changing cyber threats, reducing risks, and protecting vital assets. In deep learning autoencode accuracy 68\% less than other models. The performance of the CNN and LSTM algorithm is impressive and outperformed with 100\% accuracy on cyber security attacks datasets. Machine learning algorithm accuracy rate of SVM and KNN 100\% while logistic regression accuracy is 99\% GNB accuracy 80\% with training data of the models. The overall models perforamance deep learning increadible accuracy with 100\% on the training and testing data.
Fingerprint liveness detection using dynamic local ternary pattern (DLTP)
Authors: Bhatti Kamran Ali , Parveen Dr.Sajida , Bhatti Nadeem Naeem , Larik Kamran Ali , Soomro Qurat-ul-ain
Published: August 2024

Nowadays, biometric confirmation systems are utilized for security applications such as verification and identification. There are various biometric modalities such as fingerprints, face recognition, and iris scans. Biometric systems are superior to PIN and password-based systems because the latter can be easily stolen or forgotten, whereas biometric traits are unique and difficult to replicate or forget. Among biometric modalities, fingerprint recognition is widely employed for security purposes due to the distinctiveness of each individual's fingerprint. However, fingerprint biometric systems encounter challenges, such as the reproduction of fake fingerprints using materials like silicon, which can potentially bypass security measures. This issue is considered a significant problem in fingerprint systems.This paper proposes a new software-based method called Dynamic Local Ternary Pattern (DLTP) for fingerprint liveness detection, employing a machine learning classifier, specifically Support Vector Machine (SVM), to distinguish between live and fake fingerprints. Various experiments were conducted using DLTP and state-of-the-art texture descriptors. The results obtained from DLTP demonstrated optimal accuracy, clearly surpassing those achieved by the Local Binary Pattern (LBP) and Local Ternary Pattern (LTP) texture descriptors reported in previous studies.
AI-Powered Lung Cancer Detection From CT Imaging
Authors: Awan Tehreem , Muhammad Ali  , Mushahid Hussain  , Muhammad Rashid  , Ali Sungraiz , Noon Serosh Karim
Published: August 2024

Lung cancer is one of the deadliest forms of cancer, witnessing thousands of new diagnoses annually. Early detection remains paramount; without it, survival rates plummet drastically. This underscores the critical role of employing artificial intelligence (AI) for early diagnosis, a pivotal step in combating this devastating illness. This study introduces a sophisticated computer-aided system, aiming to revolutionize lung cancer detection through state-of-the-art convolutional neural network (CNN) technology. By harnessing the capabilities of AI and CNN's, enabling precise categorization of patients into those exhibiting normal lung tissue, benign lung nodules, or malignant lung cancer.The primary objective is to streamline early diagnosis efforts, thereby facilitating prompt intervention and treatment initiation to enhance patient outcomes and bolster survival rates. Leveraging cutting-edge technology, this innovative approach aims to transform the landscape of lung cancer diagnosis, offering hope for more effective strategies in combating this deadly disease. Furthermore, by harnessing the capabilities of AI and CNN technology, this study aims to bridge existing gaps in lung cancer diagnosis, offering new insights and opportunities for advancements in medical research and clinical practice. Ultimately, the successful implementation of this innovative approach has the potential to significantly impact the field of lung cancer diagnosis and treatment, offering hope for improved patient outcomes and increased survival rates. Through continued research and development, further advancements in AI-based diagnostic tools can be achieved, paving the way for a brighter future in the fight against lung cancer.
ANALYSIS OF THE BEHAVIOR OF TRADITIONAL MARKET TRADERS IN THE PERSPECTIVE OF ISLAMIC BUSINESS ETHICS
Authors: Kurniawan Heri , Qarni Waizul , Nasution Muhammad Lathief Ilhamy
Published: August 2024

This research is very important because it will help because evaluating the actions of conventional market traders in Natal from the point of view of Islamic business ethics shows honesty, integrity and kindness in your work. In addition, this activity can help consumers and traders do business better. The purpose of this study is to gain a better understanding of the needs of traders from the point of view of business practices. Islam targeting traditional markets in the Natal region.The research area was traditional markets in Natal. Data were collected through descriptions, interviews, observations and documents. Verification of data validity using more power, references, and visual indicators. The research shows that traders in traditional markets in Natal conduct buying and selling trade despite not knowing the principles of Islamic trade. They use rules such as not forgetting the truth and balance, not hiding mistakes, giving customers the freedom to choose, we must follow Islamic business principles, such as keeping promises, being responsible for product quality, and providing friendly services.
Where is the Real Sheep? Exploring the Baahd and Good Sheep Voices in Five Australian Picture Books.
Authors: Johnstone Amie
Published: August 2024

Farmed animals, such as sheep, featured in children’s picturebooks usually lack their own voices. Since the emergence of the animal turn, there has been an increase in the examination of children’s animal stories from literary animal studies perspectives, which destabilises the human-animal binary by challenging the human domination of other species regarding human-animal relations depicted in literature. In relation to sheep, children’s stories often rely on tropes—such as counting/listing devices, sheep providing wool, or needing to belong to a flock—along with desentientization to limit or omit sheep voices from the narratives, thus distancing young readers from empathising with sheep and reinforcing the human domination of sheep. In this paper, I draw on and expand upon Janae Dimick’s And This Little Piggy Had None: Challenging the Dominant Discourse on Farmed Animals in Children’s Picturebooks to analyse sheep in Australian picturebooks and engage with the ongoing debate regarding representing animal voices in literature. This article analyses the depiction of sheep in five Australian picturebooks and argues that sheep voices are represented mostly in conversation with humans, either on-page human characters or the implied reader, and thus deny sheep individual voices.
Rethinking Authenticity, Legitimacy, and Agency in the Context of the Six Seasons of the Asiniskaw Īthiniwak Project
Authors: Braith Melanie , Braniff Grace , Laverdure Amanda , Roloff Benjamin
Published: August 2024

This discussion, stemming from our keynote address at 2022 ACLAR Biennial Conference, brings together researchers and emerging scholars from the Six Seasons of the Asiniskaw Īthiniwak project, a community-driven research project that shares knowledge about Rocky Cree culture in northern Manitoba, Canada, through historical picture books, picture book apps, and teachers’ guides. Using this project as a case study, we reflect on the three themes of the 14th Biennial ACLAR Conference: legitimacy, authenticity, and agency. In particular, we trouble the concept of authenticity and question its usefulness for the kind of cross-cultural research that we are undertaking in the project. We document our processes for working with oral stories and translating these into written texts. We outline the community and scholarly research that grounds the textual, pictorial, and auditory representations of the picture books and apps we produce, and propose that the aspiration to historical, cultural, geographical, and linguistic accuracy at the centre of our project is a more enabling objective than a search for authenticity is. We also discuss how the curriculum materials we develop seek to connect young readers with Rocky Cree culture and use the concepts of agency and entanglement to think through these connections. The final part of this discussion considers a gathering on Rocky Cree culture that academic researchers and Rocky Cree community researchers and knowledge keepers organized collaboratively. Not only was our project initiated by Rocky Cree community members, but, as this gathering demonstrates, it also assumes an ongoing relationship with these communities.
Membekali Warga Negara di Era Post-Truth: Peran Krusial Pendidikan Kewarganegaraan di Australia
Authors: Erlande Rike , Komalasari Kokom , Taufika Ryan , Hardian Mirza , Fauzan Ahmad , Maharani Apriya
Published: August 2024

Era post-truth menimbulkan ancaman serius terhadap demokrasi dan diskursus publik. Artikel ini menganalisis peran krusial pendidikan kewarganegaraan dalam membekali warga negara dengan keterampilan dan perspektif untuk menghadapi tantangan era post-truth di Australia. Melalui pendekatan analitis dan deskriptif, serta tinjauan literatur, artikel ini menyelidiki tujuan, kurikulum, dan strategi pengajaran pendidikan kewarganegaraan, serta mengidentifikasi tantangan dan peluang dalam implementasinya. Hasil penelitian menunjukkan bahwa pendidikan kewarganegaraan di Australia bertujuan untuk mengembangkan warga negara yang aktif, terlibat, dan bertanggung jawab, dengan penekanan pada keterampilan berpikir kritis, literasi media, dan ketahanan terhadap informasi yang menyesatkan. Meskipun terdapat tantangan, kolaborasi antara pemangku kepentingan, pemanfaatan teknologi, dan pengembangan profesional bagi guru diidentifikasi sebagai strategi kunci untuk memperkuat pendidikan kewarganegaraan. Temuan dan rekomendasi yang disajikan dapat berkontribusi pada pengembangan kebijakan dan praktik pendidikan kewarganegaraan yang lebih efektif dalam menghadapi realitas era post-truth.
HUBUNGAN SELF COMPASSION DENGAN STRES PENGASUHAN PADA IBU BEKERJA YANG MEMILIKI ANAK USIA DINI
Authors: Hidayati Pratiwi Nurul , Fitroh Siti Fadjryana
Published: August 2024

Self-compassion merupakan sikap belas kasih terhadap diri sendiri, terutama ketika mengalami kegagalan dalam pengasuhan, dengan adannya Self compassion dalam diri orang tua terutama ibu bekerja dapat membantu mengatasi stres pengasuhan yang dialaminya. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana hubungan dari self-compassion dan stres pengasuhan dalam pengasuhan anak usia dini di wilayah kota Surabaya Selatan. Metode yang digunakan dalam penelitian ini adalah kuantitatif korelasional dengan pendekatan Korelasi Pearson Product Moment. Teknik sampling yang digunakan adalah Purposive Sampling, dengan jumlah responden 109 ibu bekerja di Wilayah Surabaya Selatan. Penilaian instrumen penelitian menggunakan angket penelitian dari skala likert skor 1-4. Berdasarkan perhitungan dalam uji hipotesis, dapat diketahui bahwa Ha diterima dan H0 ditolak karena diketahui nilai signifikansi sebesar 0,03. Sehingga dari perhitungan tersebut dapat disimpulkan bahwa terdapat hubungan yang negatif antara Self-compassion dengan Stres pengasuhan pada ibu bekerja yang memiliki anak usia dini di Wilayah Surabaya Selatan, yang berarti bahwa semakin tinggi self compassion yang dimiliki oleh ibu bekerja maka semakin rendah stres pengasuhan yang dialaminya. Namun derajat hubungan atau koefisien korelasinya masuk ke dalam kategori rendah yaitu sebesar -0,203. Sedangkan kontribusi atau sumbangan variabel Self compassion terhadap stres pengasuhan sebesar 4,1% dan stres pengasuhan ibu bekerja dipengaruhi oleh faktor lainnya sebesar 92,2%. Berdasarkan hasil penelitian yang dilakukan diharapkan peneliti selanjutnya dapat memperluas kajian terkait dengan faktor-faktor lain yang dapat berhubungan dan mempengaruhi stres pengasuhan selain self compassion dan dari segi subjek penelitian maupun lokasi penelitian yang semakin diperluas.
Kata Kunci: self-compassion, stres Pengasuhan, anak usia dini
WITHDRAWN: Effect of matric suction on stress-induced anisotropy behavior of unsaturated clay
Authors: Su Yanlin , Cai Guoqing , Li Jialiang , Shan Yepeng , Yang Rui
Published: August 2024

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Inhibiting neddylation induces glucose uptake and metabolism via HIF-1α/GLUT1 pathway in gastric cancer cells
Authors: Feng Siqi , Guo Yueyang , Hu Zhuang , Bai Linyue , Tang Yanjun , Hu Jingyi , Zhang Qianqian
Published: August 2024

Gastric cancer cell progression is intricately linked to their metabolic status. Neddylation inhibition, such as MLN4924, demonstrates anti-tumor effects by impacting crucial cellular processes. However, the effects of Neddylation modification on gastric cancer cell metabolism and underlying mechanisms remain poorly understood. Our study firstly confirmed the anti-tumor effect of neddylation inhibition by MLN4924. Based on metabolite analysis, MLN4924 promoted glucose metabolism and nucleotide synthesis. Mechanistically, MLN4924 increased the accumulation of HIF-1α by inhibiting cullin 2 neddylation, which led to the upregulation of glucose transporter 1 (GLUT1) expression and activity. Importantly, the combination Interestingly, attenuation of MLN4924-induced apoptosis occurred upon either knocking down or inhibiting GLUT1, emphasizing its role in mitigating MLN4924's apoptotic activity. We observed metabolic alterations, notably an upregulation of GLUT1, a key protein associated with metabolic regulation. This led to increased glucose uptake and metabolism within gastric cancer cells, ultimately diminishing MLN4924’s anti-tumor effectiveness. Furthermore, our findings revealed that HIF-1α mediated the upregulation of GLUT1 induced by MLN4924. In mouse models bearing MGC-803 cell xenografts, co-administration of a GLUT1-specific inhibitor remarkably enhanced the therapeutic efficacy of MLN4924. Combining MLN4924 with a GLUT1 inhibitor presents a potential novel therapeutic strategy for gastric cancer treatment.
Frustrated charge density wave and quasi-long-range bond-orientational order in the magnetic kagome FeGe
Authors: Blanco-Canosa Santiago , Subires David , Kar Arunava , Korshunov Artem , Fuller Chloe , Yi Jiang , Hu Haoyu , Calugaru Dumitru , McMonagle Charles , Yi Changjiang , Roychowdhury Subhajit , Shekhar Chandra , Strempfer Joerg , Jana Anupan , Vobornik Ivana , Dai Ji , Tallarida Massimo , Chernyshov Dmitry , Bosak Alexey , Felser Claudia , Bernevig B. Andrei
Published: August 2024

The intrinsic frustrated nature of a kagome lattice is amenable to the realization of exotic phases of matter, such as quantum spin liquids or spin ices, and more recently the multiple-q charge density waves (CDW) in the kagome metals. Despite intense efforts to understand the mechanism driving the electronic modulations, its origin is still unknown and hindered by competing interactions and intertwined orders. Here, we identify a dimerization-driven 2D hexagonal charge-diffuse precursor in the antiferromagnetic kagome metal FeGe and demonstrate that the fraction of dimerized/undimerized states is the relevant order parameter of the multiple-q CDW of a continuous phase transition. The pretransitional charge fluctuations with propagation vector q=qM at TCDWB-phases reported in liquid crystals and transient states of CDWs and highlight the key role of the topological defect-mediated melting of the CDW in FeGe.
Assessment of Lightning Mortality in the United States from 1979 – 2022
Authors: Marion Jason W , Lanning Eli , Brown D. Gary
Published: August 2024

Climate change has been linked to an increased prevalence of lightning activity associated with hazardous storm formation. An increased frequency in lightning activity in the United States (US) would presumably increase the risk and incidence for lightning-related injuries and fatalities. Using cause of death data available from the US Centers for Disease Control and Prevention (CDC) via their WONDER online databases and the National Weather Service, the results showed a steady decline in the lightning-related mortality incidence and incidence rates in the US from 1979–2022. In the early 1980s, U.S. death rates were near four per 10 million, and are now near one per 10 million. Death rates in the American South are higher, but have also experienced improvement, having fallen from near six per 10 million in the early 1980s to two per 10 million in recent years. A limitation of this study is a lack of data on lightning-related injuries. Overall, the steady decline in lightning-related deaths in the US likely is related to a multitude of factors including early storm reporting, improved risk communication, improved public education regarding the hazard, increased urbanization and mechanization of outdoor work, improvements in emergency medical care, among other weather-related risk reduction strategies. These results highlight the success of risk reduction strategies for reducing lightning-associated mortality in the US while the threat of hazardous lightning has likely continued to increase.
Characteristics of Macrobenthic Communities and their Response to Environmental Changes in East Taihu Lake, China
Authors: Yang Changming , Ding Shuhan , Niu Yangdan , Zhang Xiang , Li Jianhua
Published: August 2024

As an important component of aquatic ecosystems, benthic animals are sensitive bioindicators for evaluating water pollution. In this study, we investigated the diversity of macrobenthic communities and analyzed the pivotal environmental factors affecting alterations in the macrobenthic communities of East Taihu Lake. This analysis was augmented by controlled laboratory simulation experiments designed to elucidate and validate the responses of critical indicator species within various functional zones to environmental shifts. This study shows:(1) Bellamya purificata, Limnodrilus and Tubifex were the dominant species on a year-round scale. Water depth was the most important environmental factor affecting the macrobenthic communities;(2) Simulation experiments revealed that the growth condition of Bellamya was significantly worse in the simulated entrance area than in the simulated original enclosure aquaculture and wetland areas. The growth of Radix auricularia was significantly better in the presence of aquatic plants than in the absence of plants, and was more significantly influenced by environmental factors closely related to aquatic plants. The densities of Annelida were significantly higher in the treatment group without plants than that with plants, generally showing the trend of the simulated original enclosure aquaculture area > the simulated entrance area > the simulated wetland area. The trend of diversity was mainly influenced by environmental factors such as turbidity and eutrophication index of the water, which was consistent with the results of the field survey.
Predicting the state of charge of lithium ion battery in E Vehicles using Box-Jenkins combined Artificial Neural Network Model
Authors: Louis Glarida Amala , Sampathkumar Siddharth
Published: August 2024

This manuscript used artificial neural networks to predict the state of charge of lithium-ion batteries in electric vehicles. For this, a hybrid model that combined Box–Jenkins and artificial neural network techniques was used. The original Auto-Regressive Moving Average (ARMA) model was developed in three stages: finding the best fit using Auto-Correlation Function (ACRF) and Partial Auto-Correlation Function (PACRF) in the first stage, parameter estimation in stage two & verification in stage three using the Ljung-box technique. For the purpose of estimating the dynamic system response, the second model was developed using a Multi-Layer Perceptron (MLP) network with feedforward backpropagation. Prediction accuracy was significantly increased by the combination model, which integrated non-linear Artificial Neural Network model with linear Auto-Regressive Moving Average model. Notably, the state of charge of lithium-ion batteries in electric vehicles could be accurately predicted using a four-parameter model that included Charge Rate, Voltage, Depth of Discharge, and Energy Density.
Associations between novel anthropometric indices and cognitive function among U.S. older adults
Authors: Tan Zhichun , Deng Hongmei , Nie Yaxin , Yan Ning , Ai Lixin
Published: August 2024

Background
Previous obesity indices have struggled to accurately account for the relationship between obesity and cognitive function, and the purpose of this study was to investigate the relationship between two novel anthropometric indices: A body size index (ABSI) and body roundness index (BRI), and cognitive function in an older population in the United States.
Methods
This study utilized data from the National Health and Nutrition Examination Survey (NHANES) 2011–2012 and 2013–2014. To evaluate cognitive function, three cognitive assessments were employed: the Consortium for the Establishment of an Alzheimer's Disease Registry (CERAD) test, the Animal Fluency Test (AFT), and the Digit Symbol Substitution Test (DSST). Logistic regression analyses were further applied to investigate the association between ABSI/BRI and cognitive test scores, as well as with the odds of cognitive impairment (CI) prevalence, respectively. A smoothed fitting curve was also used to describe the nonlinear negative association between the above two novel anthropometric indices and cognitive function. Interaction tests and subgroup analyses were also performed.
Results
The study included 2639 older participants aged 60 years and older. After adjusting for confounding variables, our analyses revealed a statistically significant negative association between ABSI and BRI and cognitive function. Compared with individuals in the lowest quartile of the ABSI, individuals in the highest quartile had decreased CERAD scores (β = -0.69, 95% CI: -1.36, -0.03, p-value = 0.0401) and decreased DSST scores (β = -2.15, 95% CI: -3.58, -0.72, p-value = 0.0033). Individuals in the second quartile had decreased CERAD scores compared to individuals in the lowest quartile of BRI (β = -0.68, 95% CI: -1.35, -0.01, p-value = 0.0479). In addition, higher ABSI was significantly associated with a higher prevalence of CI, with an increased odds of CI prevalence in individuals in the highest quartile compared to individuals in the lowest quartile of ABSI (CERAD OR = 1.50, 95% CI: 1.01, 2.24, p-value < 0.0458; DSST OR = 1.68, 95% CI: 1.20, 2.33, p-value = 0.0093).
Conclusions
ABSI and BRI were strongly associated with cognitive decline among US. older adults. In addition, higher ABSI levels may be positively associated with the odds of CI prevalence.
Relationship between Prices of Fixed-dose and Free-equivalent Combination: A Survey of Medicines in China's National Reimbursement Drug List
Authors: FENG YIMAN , Li Wei , Wang Jiayun , Ding Jinxi , Jin Chunlin
Published: August 2024

Objectives This study investigates the relationship between the prices of fixed-dose combinations (FDCs) and free-equivalent combinations (FECs) within China's National Reimbursement Drug List (NRDL). The focus is on comparing their price ratios.Methods We identified FDCs and FECs listed in the NRDL, along with recent bidding data. Publicly listed prices and characteristics of these medications were collected from Chinese government websites and commercial databases. Price ratios were calculated after adjusting for the active pharmaceutical ingredient's strength and dosage form, following the "Chinese Pharmaceutical Differential Pricing Rules."Results The analysis showed that the price ratios of FDCs to FECs in the NRDL averaged 1.11 ± 0.77 (Mean ± Standard Deviation). The price ratios varied significantly across different therapeutic areas, with the highest ratios observed in cardiovascular system drugs, followed by systemic anti-infective agents, digestive tract and metabolism drugs, and respiratory system drugs. FDCs in the negotiation catalog had lower and more stable price ratios compared to those in the regular catalog. The significant price reduction of FECs or FDCs due to the volume-based procurement (VBP) program also affected their price ratios.Conclusions The relationship between the prices of FDCs and FECs within China's NRDL is not clearly defined. These price ratios vary substantially across different therapeutic areas and drug categories and are influenced by the VBP program. These findings provide valuable insights for decision-makers on pricing strategies for newly reimbursed FDCs.
IMEGAR: An Enhanced Hybrid Genetic Algorithm for Dynamic Influence Maximization in Social Networks
Authors: Iranmanesh Amir , Rahgozar Masoud
Published: August 2024

During the last decade, social networks have received particular attention as a new platform for advertising and the diffusion of information, especially in viral marketing. In addition, we recently witnessed that the structure of social networks is continuously changing and expanding in terms of size and complexity. Generally, social networks consist of nodes and communication edges between them. Precisely, these edges determine the communication between people in the network. This communication can be supportive, educational, friendly, political, etc., depending on the type of social network. When we consider the fact that humans with all their unique qualities, mentally and physically, are the nodes of these social networks, we face challenges and complications that cannot be solved and paid attention in any of the previous methods for the IM problem in the past. In this paper, we employed an optimized heuristic to disseminate practical information in the least amount of time, followed by leveraging social reinforcement and memory. Furthermore, by utilizing an advanced and efficient genetic algorithm with novel and enhanced operators, we can effectively address the Influence Maximization problem and identify the most influential set of seeds within the dynamic social network, as demonstrated in the experiments section.
Structural, thermal and electrical properties of Na1+xAlxTi2-xP3O12 (x = 0.3) solid electrolytes
Authors: Adetona Ademola J. , Wang Ge , Nejo Ayorinde O. , Shaw Cheryl , Siame Beatia In
Published: August 2024

Investigation of the commercially available Na1.3Al0.3Ti1.7(PO4)3 (NATP) solid electrolyte for Na-ion solid-state batteries (SIBs) application requires a comprehensive understanding of its microstructural, thermal behaviour and electrical properties. In this study, we investigated the solid electrolyte properties of NATP through different spectroscopic techniques, including XRD, SEM, DSC/TGA, Dilatometer, and Impedance Spectroscopy. The impact of sintering temperature on the densification, microstructural and electrical properties was investigated. Both Archimedes and geometric density measurement methods were utilised to determine the relative density (ρr) of the sintered ceramics. Additionally, we investigated the optimum temperature at which the AlPO4 secondary phase is suppressed/minimised for this solid electrolyte. Refinement of the phases present in the NATP was studied using Topas 5 software to provide insight into the crystalline structure of the ceramic. The ionic conductivity studies of the NATP solid electrolyte were found to be in the range of 10− 7 – 10− 8 S/cm at 25°C, and the activation energies were in the range of 0.46 ± 0.35 eV. This study provides a thorough understanding of NATP properties, indicating its potential as a solid electrolyte.
Player Walkovers in Professional Men’s Tennis Tournaments from 1973 to 2019
Authors: Casals Martí , Curbelo Victoria Peña , Pablo Bernat , Ampuero Rodrigo , Cortés Jordi , Baiget Ernest
Published: August 2024

Purpose
In tennis, there exist different types of situations in which players are unable to finish a match or a tournament. Walkovers (W/O) refer to when a player wins a match due to the absence of his/her opponent. This investigation aimed to describe W/O in Association of Tennis Professional (ATP) tournaments between 1973 and 2019, analysing epidemiological patterns and associated factors.
Methods
A retrospective cohort study was conducted, analysing 168137 matches. Factors that might influence W/O were studied by epidemiological measures, including both absolute and relative measures of risk incidence proportion (IP) per 1000 played matches and cumulative incidence ratio (CIR) are provided as association measures.
Results
The IP was 4.2 (95%CI: 3.9–4.5). Master tournaments showed the higher IP (5.5; 95%CI: 4.6–6.6). Carpet courts were the ones with a higher IP (6.3; 95%CI: 5.2–7.6). The matches with 3 sets had a 2.5% greater risk comparing with those with 5. The primary causes of W/O were attributed to injuries (28.7%), illnesses (7.8%), and personal reasons (2.5%), although the majority of reasons remained unknown (61.0%).
Conclusion
This study provides a comprehensive understanding of W/O in professional tennis, highlighting epidemiological patterns. These findings have practical implications for athletes, coaches, and organizers, guiding preventive strategies and future research.