bluuebunny/crossref_metadata_2025 huggingface dataset:
Hormone Receptor Status in Histologically Proven Carcinoma Breast
Authors: Sivakumar Anoop , Ganapath Aravind S.
Published: April 2024

Background:

Carcinoma breast is considered a heterogeneous disease with a varied spectrum of clinical, pathological and molecular features. The molecular classification of breast carcinoma is becoming the gold standard for its complete characterisation. Oestrogen receptor (ER) and progesterone receptor (PR) are routinely performed on all breast cancer specimens and are reliable, inexpensive and useful for therapeutic decision-making.

Aim:

The aim of the study was to find out the proportion of hormone receptor positivity in cases of breast cancer.

Materials and Methods:

This is a 1-year cross-sectional study conducted in general surgical wards of our institution. The sample size was 50. The selected patients were subjected to either of the following surgical treatments which are simple mastectomy, modified radical mastectomy or breast conservation surgery. After the surgery, the histopathological specimens were reviewed, and hormone receptor status was studied.

Results:

Ninety-six per cent of the study population had infiltrating ductal carcinoma and mucinous and metaplastic carcinoma constituted the remaining 4%. In this study, 35 (70%) had ER positivity and 28 (56%) had PR positivity on immunohistochemistry. Of all the factors studied, only age at first childbirth had a significant association with hormone positivity. 52.9% of women in the ER-positive group had first childbirth at or after 23 years. Only 14.3% of women with first childbirth at or after 23 years had ER negativity.

Conclusion:

The prevalence of hormone receptor positivity obtained in this study is more when compared to most of the studies from India and is comparable to the studies in Western literature.
Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment
Authors: Tan Ying-Ying , Liu Ying-Ying , Zhai Yi-Yan , Wang Yi-Xuan , Wu Zhi-Shan , Stalin Antony , Cheng Guo-Liang , Li Bing , Wu Chao , Huang Zhi-Hong , Lu Shan , Fan Xiao-Tian , Zhao Zheng , Wu Jia-Rui
Published: April 2024

Objective:

Huazhi Rougan granules (HRGs) are a promising drug to improve alcoholic liver disease (ALD), but its mechanism remains unclear.

Materials and Methods:

Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD.

Results:

A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver.

Conclusions:

This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.
A phase-field version of the Faber–Krahn theorem
Authors: Hüttl Paul , Knopf Patrik , Laux Tim
Published: April 2024

We investigate a phase-field version of the Faber–Krahn theorem based on a phase-field optimization problem introduced by Garcke et al. in their 2023 paper formulated for the principal eigenvalue of the Dirichlet–Laplacian. The shape that is to be optimized is represented by a phase-field function mapping into the interval

[0,1]

. We show that any minimizer of our problem is a radially symmetric-decreasing phase-field attaining values close to

0

and

1

except for a thin transition layer whose thickness is of order

\varepsilon>0

. Our proof relies on radially symmetric-decreasing rearrangements and corresponding functional inequalities. Moreover, we provide a

\Gamma

-convergence result which allows us to recover a variant of the Faber–Krahn theorem for sets of finite perimeter in the sharp interface limit.
Application of a Comprehensive Lagrangian–Eulerian Spark-Ignition
Model to Different Operating Conditions
Authors: Kazmouz Samuel J. , Scarcelli Riccardo , Bresler Matthew
Published: April 2024

Increasing engine efficiency is essential to reducing emissions, which is a
priority for automakers. Unconventional modes such as boosted and highly dilute
operation have the potential to increase engine efficiency but suffer from
stability concerns and cyclic variability. To aid engineers in designing
ignition systems that reduce cyclic variability in such engine operation modes,
reliable and accurate spark-ignition models are necessary. In this article, a
Lagrangian–Eulerian spark-ignition (LESI) model is used to simulate electrical
discharge, spark channel elongation, and ignition in inert or reacting crossflow
within a combustion vessel, at different pressures, flow speeds, and dilution
rates. First the model formulation is briefly revisited. Then, the experimental
and simulations setups are presented. The results showcase the model’s ability
to predict the secondary circuit voltage, current, and power signals, in
addition to the spark channel elongation, for the inert cases, or flame front
growth, for the reacting cases. The results also compare simulation spark
channel and flame growth plots to experimental Schlieren images at different
instants in time. This work serves to highlight LESI’s ability to predict the
characteristics of discharge and ignition across a variety of operating
conditions.
Suitability Study of Biofuel Blend for Light Commercial Vehicle
Application under Real-World Transient Operating Conditions
Authors: Saiteja Pajarla , Ashok B.
Published: April 2024

Driving schedule of every vehicle involves transient operation in the form of
changing engine speed and load conditions, which are relatively unchanged during
steady-state conditions. As well, the results from transient conditions are more
likely to reflect the reality. So, the current research article is focused on
analyzing the biofuel-like lemon peel oil (LPO) behavior under real-world
transient conditions with fuel injection parameter MAP developed from
steady-state experiments. At first, engine parameters and response MAPs are
developed by using a response surface methodology (RSM)-based multi-objective
optimization technique. Then, the vehicle model has been developed by
incorporating real-world transient operating conditions. Finally, the developed
injection parameters and response MAPs are embedded in the vehicle model to
analyze the biofuel behavior under transient operating conditions. The results
obtained for diesel-fueled light commercial vehicle (LCV) have shown better fuel
economy than LPO biofuel with their developed fuel injection parameter MAP. The
maximum BTE obtained was 29.7% for diesel and 29.5% for LPO at 2100 rpm and 20
Nm torque. The mean HC emissions were identified as 0.02046 g/km for diesel and
0.03488 g/km for LPO fuel over the modified Indian driving cycle (MIDC). Except
for NOx emission, LPO biofuel exhibited diesel-like performance and emission
characteristics under the MIDC.
Analytical Investigations on Silver, Copper and the Earliest Tin Bronzes from Ur
Authors: Salzmann Eveline , Klein Sabine , Hauptmann Andreas
Published: April 2024

The present study is focused on the investigation of metal objects: particularly copper, arsenical copper, copper-tin alloys and silver objects excavated at the cemetery of Earl Bronze Age Ur in Mesopotamia. A key to understand economic and cultural relationships between Mesopotamia and other Early Bronze Age cultures lies in the analytical investigation of this archaeological objects having the potential to answer specific archaeological questions. One is the question of the Bronze Age raw material supply of the region in question which may be traceable through the archaeological material. The present results already point to the geological setting, in which the source regions for copper and silver from Ur are located.
Carolingian and Ottonian Brass Production in Westphalia Evidence from the Crucibles and Slag of Dortmund and Soest
Authors: Merkel Stephen
Published: April 2024

The abundant new crucible and slag finds from the Thier-Brauerei excavation in the center of medieval Dortmund have provided a  stimulus to revive the discussion of Westphalian brass cementation technology in the Carolingian and Ottonian periods and to explore unanswered questions concerning the process and its potential outcome. A total of sixteen crucibles and slag samples from stratified  deposits in the Dortmund-Thier-Brauerei and Soest-Plettenberg excavations were prepared for optical and scanning electron microscopy to analyze metallic inclusions, slag phases and crucible ceramic. The copper and brass inclusions within the crucibles and  their adhering slag from Dortmund show a relationship between lead and zinc contents and indicate that lead-bearing calamine ore  was heated with charcoal and copper metal to produce leaded brass. Ternary Cu-Zn-Pb alloys are common for contemporary bar-shaped ingots, which supplied casting industries in early medieval Northern European towns like Hedeby and Kaupang. Concerning the zinc-rich black slag lining the interior of some crucible fragments, they regularly showed increases in lime and iron oxides in relation to  the crucible ceramic and thus reflect impurities coming from the zinc ore. The lead-silicate slags often found in association with  crucible finds in Dortmund have yet to have a clear interpretation; although the lead isotope analysis of crucibles and lead-silicate slag  shows they may have the same source of lead, the production of the lead-silicate slag is definitely unrelated to the metallurgical process occurring inside the cementation crucibles themselves.
Knowledge Regarding Therapeutic Hypothermia and Its Uses Among Staff Nurses of Selected Hospitals
Authors: Hiwale Samuel Nilesh , Soudagar Needa Abubakar , Kale Sneha , Kumbhar Rushikesh D. , Rananavare Jayshri , Talsandekar Amos P. , Rathod Suchitrarani
Published: April 2024

Therapeutic hypothermia, also known as targeted temperature management, has gained prominence in recent years for its diverse applications in healthcare, particularly in critical care and emergency medicine. To ensure its effective utilization, it is imperative to assess the knowledge of healthcare professionals, including staff nurses, who play a crucial role in its implementation. A descriptive research design was employed for this study. Non-probability purposive sampling was used to select a sample of staff nurses from selected hospitals. The findings of this study indicate that there is no significant association between the knowledge scores of staff nurses regarding therapeutic hypothermia and its applications and their socio-demographic variables. This suggests that the level of knowledge among staff nurses remains consistent across different demographic groups. Therapeutic hypothermia is a critical intervention in modern healthcare, and it is essential for healthcare professionals, including staff nurses, to possess adequate knowledge about its principles and applications. While this study did not identify significant variations in knowledge based on socio-demographic factors, it highlights the need for continuous education and training to ensure that staff nurses are well-equipped to deliver optimal care to patients who may benefit from therapeutic hypothermia. Further research is encouraged to explore the effectiveness of educational interventions in enhancing knowledge and practice in this area.
Estetik Bir Grafik Tasarım Ürünü Olarak Barkod Tasarımlarının İncelenmesi
Authors: Yücelen Bora Bekir , Mercin Levent
Published: April 2024

Hızlı tüketim alışkanlıkları, işlenebilir gıda çeşitlerinin artmasıyla birlikte, sektör genelinde firma sayısında belirgin bir artışa yol açmıştır. Bu artış, ambalajlı ürünlerin çeşitliliğinde belirgin bir yükselişe sebep olmuştur. Firmalar, ürünlerini diğerlerinden ayırt edilmesini sağlamak ve öne çıkartmak için ürünlerin nitelikleriyle ilgili özelliklerini zenginleştirmeye, reklam kampanyaları yapmaya veya ambalaj tasarımlarını daha dikkat çekici hale getirmeye ihtiyaç duymaktadır. Bu yüzden, firmalar ürünlerini benzerlerinden ayıran özelliklerini öne çıkartmak ve fark edilebilirliğini artırmak amacıyla, ambalaj tasarımlarında görsel ve tipografik kompozisyonlar kullanmayı tercih etmektedir. Bu görsellerden biri de barkodlardır. Bir grafik simge olarak barkodun ambalaj üzerindeki asıl amacı bilgi ve iletişim kurmak olsa da ambalaj yüzeyindeki diğer görselleri tamamlayan ve estetik değer katan birer görsel imgeye de dönüşebilmektedir. Bu çalışmada, barkodların ambalaj tasarımlarında işlevsel bir grafik simge olup olmadığı, aynı zamanda estetik bir imge olarak da yer alıp alamayacağı; ambalaj tasarım bütünlüğünü tamamlama ve ona değer katan bir unsur olup olmadığı araştırılmıştır. Araştırmada genel tarama modellerinden ilgili literatürün taranması ve eser analizi yöntemlerinden yararlanılmıştır. Elde edilen verilere göre barkodların estetik bir unsur olarak öne çıktığı tasarımlar incelendiğinde, tasarımların genel olarak ambalajın formuna, ambalaj üzerinde kullanılan şekil ve imgelerin konumuna, yüzeydeki renk ve çizgilerin değerine kurgulanmış ve çoğunlukla çizgi ve rakamlardan oluşan bir anlayış ile ortaya kondukları gözlemlenmiştir. Görsel unsurların iletişim alanında kullanımının kaçınılmaz olduğu çağımızda gerek ambalaj tasarımı gerek sanat nesnesi olarak barkod tasarımlarının, toplumun estetik algısını zenginleştirerek, asıl amaç ve işlevinin ötesinde sanat ve tasarım dünyasına farklı bir görsel miras olarak yansıdığı söylenebilmektedir.
Grafik Tasarımda 21. Yüzyıl Tasarım Trendleri ve Yönelimleri
Authors: Kaya Sefa Ersan
Published: April 2024

Grafik tasarım, teknolojik gelişmeler, kültürel değişimler ve iletişim yöntemlerinin evrimi bağlamında anlatım olanakları ve ifade biçimlerinde değişimler yaşamıştır. Mobil cihazlar, internet, sosyal medya gibi faktörler grafik tasarımın dilini ve kitlesini değiştirmiştir. Teknolojik evrim ve iletişim gereklilikleri, tasarımın temel ilkeleri üzerinde etkili olmuştur. Grafik tasarımın çok katmanlı yapısı, farklı ekran yüzeyleri ve farklı demografik yapı olanaklarıyla erişimi kolaylaştırmıştır. Erişimin kolaylaşması insan-bilgisayar kavramını ortaya çıkarmıştır. Bu tanımlama ile grafik tasarımın geleceği yeniden şekillenmiştir. Bu çalışma kapsamında grafik tasarımın 21. yüzyıl trend ve yönelimlerindeki konular; sadelik ve işlevsellik, mobil uyum/duyarlı tasarım, kinetik tipografi ve VR/AR uygulamalarının grafik tasarıma olan entegrasyonu olarak ele alınmıştır. Bu disiplinler arası alan entegrasyonunda tasarım yaklaşımlarına alternatif çözümleme ve yaratım desenleriyle bir bakış sunulmuştur. Çalışmanın amacı, grafik tasarımın farklı alanlara entegrasyonu ve mantıksal ilişkilerine dair biçimsel bir bakışı ortaya koymaktır. Etkili tasarım uygulamalarına duyulan ihtiyaç ve sektöre özgü grafik formların geliştirilmesi, grafik tasarımda gelecekteki araştırma ve yenilikler için önemli alanlar olarak vurgulanmaktadır.
Food supply in the context of destabilization of the global economy
Authors:   Kazakh Research Institute of Economy of Agro-Industrial Complex and Rural Development, Moldashev A. , Fedorova E.Ya. ,   Federal Research Center “Yakut Scientific Center of the Siberian Branch of the Russian Academy of Sciences”, Dzhambayeva G.A. ,   Kazakh Research Institute of Economy of Agro-Industrial Complex and Rural Development
Published: April 2024

The goal is to analyze the state of food supply for the country's population in the context of destabilization of the world economy, inflation of prices for goods, primarily food, which in recent years have had a steady growth pattern. Methods – comparative analysis, economicstatistical, cause-and-effect. Results - the main signs of instability in economic situation in the world, their characteristics, main causes and consequences are revealed. The average annual growth rate of agricultural production for 2000-2020, 2020-2022 is shown and their impact on per capita supply of basic products and consumption rates. Comparison of these indicators allows to identify actual level of food support in Kazakhstan for specific years. The authors note that in the last two decades, physiological dietary and calorie standards for certain food products have not yet been achieved. Food security is also determined by the share of imports in consumer demand. Conclusions - it is recommended in the near and medium term to take effective measures to increase main types of products to volumes that will allow to move to import substitution and per capita consumption to the standards of physiological needs. Measures of state support to create favorable economic and organizational conditions for doing business in agricultural sector of the republic are proposed. Resolving food issue is recognized as the highest priority of government policy. The results of the study have practical significance for the organization and management of food supply system. It is important to promote the use of innovative technologies for production, processing, storage and rational use of food; formation of effective system for distribution of raw materials and agricultural products from producers to the final consumer; development of transport and warehouse infrastructure for wholesale trade.
Econometric analysis of the development of labor potential of agro-industrial complex of Kazakhstan
Authors:   K. Kulzhanov Kazakh University of Technology and Business, Saginova S. , Stukach V. ,   P. A. Stolypin Omsk State Agrarian University, Sultanova G. ,   Eurasian Integration Institute
Published: April 2024

The goal is to reveal the basis for the formation of labor potential in agriculture, its condition and role in socio-economic development of rural areas. Consider theoretical foundations of economic and mathematical modeling of dynamics of the formation of human resources in agro-industrial complex of Kazakhstan. Methods - application of methodology for carrying out forecast calculations based on econometric model in the form of a system of joint equations, tracing the connection of labor market with changes in demographic structure of the country's rural population. The study used statistical data series provided by the Bureau of National Statistics of the Agency for Strategic Planning and Reforms of the Republic of Kazakhstan. An overview of government support measures aimed at increasing labor reserves in rural areas is presented. As a result of scientific research, calculation forecast models were obtained, on the basis of which the values of main statistical indicators characterizing the dynamics of labor activity in rural areas of the republic for the long-term period were determined. Results - ways to overcome negative trends that slow down labor activity and form effective labor potential in rural areas are proposed: ensuring real growth in rural employment in all areas of activity; creation of additional high-performance jobs; improvement of social infrastructure. Conclusions - based on forecast calculations of indicators reflecting the directions of development of human capital in agricultural sector, opportunities for increasing GDP of products (services) of agriculture, forestry and fisheries have been identified. Studying the problems of rural labor economics makes it possible to note imbalances in the supply and demand of qualified specialists. In this regard, there is a need for active labor policy, stimulation of job search, training in professional skills, acquisition of a new profession.
Formation of human capital in agricultural sector of the Republic of Kazakhstan in digital space
Authors:   D. Serikbayev East Kazakhstan Technical University, Suіeubayeva S. N. , Kozlova M. ,   D. Serikbayev East Kazakhstan Technical University, Ozpence O. ,   Pamukkale University
Published: April 2024

The goal is analytical review of the current situation on formation of human capital in agricultural sector of the Republic of Kazakhstan, identifying the main problems and opportunities, as well as providing specific recommendations for optimizing development of labor potential in the context of digital transformation. Methods – statistical analysis, calculation of indicators, generalization, monographic. Results – the role of personnel reserves in AIC as a determining factor in increasing agricultural production volumes is considered. The main factors influencing on labor resources in agricultural sector of the republic in the conditions of digitalization are systematized: lack of qualified workers, aging workforce, unfavorable demographic situation, underdeveloped social infrastructure of the village, migration of the working population. It is emphasized that training of young specialists, as well as improving the quality of educational and methodological systems are an integral part of solving these problems. An analysis of the level of digital literacy of villagers and degree of the use of information and communication technologies was carried out. The state and dynamics of employment of rural residents, its differences in rural and urban areas have been studied, the share of people employed in agriculture, the structure of the economically active population by level of education have been determined. Conclusions - based on the results of the study, the need to train personnel capable of effectively using modern digital technologies in agricultural sector is noted, and measures to attract young people with specialized skills are argued. It is necessary to expand the continuous chain of career guidance, staff development to update professional competencies, and implement industry strategic goals. Practical recommendations for the development of human capital in the conditions of informatization and digitalization are proposed.
Regulation of labor migration in rural areas
Authors:   Narxoz University, Konarbayeva M. M.
Published: April 2024

Goal – the article examines the process of outflow of highly qualified specialists from rural areas, its reasons, since this trend is relevant for the Republic of Kazakhstan and the world community. Methods – retrospective analysis, demographic and economic statistics, index, graphic, comparisons and generalizations. Results – the main directions of Kazakhstan’s migration policy are considered. The authors analyzed data on the number and share of the urban and rural population in the republic, based on statistics. The balance of interregional migration is presented, since demographic and economic results affect the economy regardless of its level of development. Conclusions – attention is focused on the process of urbanization in the context of globalization, which negatively affects the number of rural residents. Internal migration is interconnected with international migration, the possibility of moving to other states. Currently, migration processes in the country have undergone changes, due to the transformation of values and migration factors, which represent specific results of the current stage of socio-economic and political development of Kazakhstan, which is confirmed by analytical information from 2013 to 2023. Government measures, reflected in resettlement programs, are aimed at stimulating national economy, quantitative transformations of the ethnic composition in the receiving areas, as well as modifications in the structure of labor market. Current issues of labor migration: labor shortage, natural and migration population decline. Tracking these indicators is difficult due to the unorganized labor market, labor intensity of this work and the need for significant financial resources.
Capítulo III. El Decreto-Ley 3/2017, de 19 de diciembre sobre la renta mínima de inserción social en Andalucía
Authors: Moreno Linde Manuel
Published: April 2024

SUMARIO: 1. LA RENTA MÍNIMA DE INSERCIÓN EN ANDALUCÍA: CUESTIONES GENERALES 1.1. Las rentas mínimas de inserción social y el contexto socio-económico 1.2. Marco normativo y competencial de la Renta Mínima de Inserción Social en Andalucía 1.3. El Decreto-Ley 3/2017, de 19 de diciembre, por el que se regula la Renta Mínima de Inserción Social en Andalucía: análisis preliminar 2. ASPECTOS SUSTANTIVOS DE LA RENTA MÍNIMA DE INSERCIÓN SOCIAL EN ANDALUCÍA 2.1. Concepto y características de la Renta Mínima de Inserción Social 2.2. Ámbito subjetivo 2.3. Requisitos exigidos a las unidades familiares para acceder a la Renta Mínima de Inserción Social 2.4. Cuantía y duración de la prestación 3. EL PLAN DE INCLUSIÓN SOCIOLABORAL 3.1. Concepto y características 3.2. Elaboración, seguimiento y finalización del Plan 3.3. Contenido 4. PROCEDIMIENTO DE CONCESIÓN DE LA RENTA MÍNIMA DE INSERCIÓN SOCIAL EN ANDALUCÍA 4.1. Procedimiento general de concesión de la Renta Mínima de Inserción Social 4.2. Procedimiento de tramitación y acreditación de la situación de urgencia y emergencia social 5. EFECTOS, EJECUCIÓN Y EXTINCIÓN DE LA RENTA MÍNIMA DE INSERCIÓN SOCIAL EN ANDALUCÍA 5.1. Pago de la prestación 5.2. Suspensión temporal de la percepción de la Renta Mínima de Inserción Social 5.3. Modificación de la Renta Mínima de Inserción Social 5.4. Extinción de la Renta Mínima de Inserción Social 5.5. Reintegro de prestaciones indebidamente percibidas 5.6. Sistema de información para la gestión de la Renta Mínima de Inserción Social 6. ASPECTOS ORGANIZATIVOS, FINANCIEROS Y PRESUPUESTARIOS DE LA RENTA MÍNIMA DE INSERCIÓN SOCIAL EN ANDALUCÍA 6.1. Ámbito competencial 6.2. Estructuras de coordinación y seguimiento 6.3. Aspectos financieros y presupuestarios
Capítulo VII. La Ley 4/2017, de 25 de septiembre, de los derechos y la Atención a las personas con discapacidad en Andalucía
Authors: Quesada Lumbreras Javier Eduardo
Published: April 2024

SUMARIO: 1. INTRODUCCIÓN. 2. LA NORMATIVA INTERNACIONAL EN LA MATERIA. 3. LA REGULACIÓN ESPAÑOLA Y SU DESARROLLO AUTONÓMICO EN ANDALUCÍA. 3.1. ¿Hemos avanzado tanto como se deduce de los textos normativos? 3.2. Principales novedades de la Ley 4/2017, de 25 de septiembre, de los Derechos y la Atención a las Personas con Discapacidad en Andalucía. 4. RETOS PRINCIPALES EN EL ÁMBITO DE LA DISCAPACIDAD. 5. CONCLUSIONES. 6. BIBLIOGRAFÍA.
The Urgency of Comprehensive and Integrated Digital Asset Regulation
Authors: Alfiani Francisca Romana Nanik
Published: April 2024

Cryptocurrency has grown rapidly since it was first introduced to the public. Many countries, including Indonesia, have begun to adopt special regulations for cryptocurrencies in response to the exponential growth and penetration of cryptocurrencies in the traditional financial system. Regulations aim to protect investors, ensure economic stability, and prevent illegal activities such as terrorism, money laundering and tax evasion. In January 2023, Law Number 4 of 2023 concerning Development and Strengthening of the Financial Sector ("UU P2SK") was enacted as a form of financial sector reform. Starting January 2025, regulation and supervision of cryptocurrency transactions will be carried out by the Financial Services Authority (OJK) replacing the Commodity Futures Trading Supervisory Agency (Bappebti) which has established several regulations regarding Crypto assets. But until now There are no regulations regarding permits or prohibitions for influencers/celebrities in marketing crypto assets via social media or other media to the public even though these regulations are needed to mitigate the incidence of victims and losses, as in several cases that have occurred. In the future, a comprehensive and integrated regulation is needed with other laws and regulations such as the Terrorism Law, the Money Laundering Crime Law, the Consumer Protection Law, the ITE Law, the Criminal Code and other related laws and regulations, in order to keep up with the rapid development of cryptocurrency and the changing character of the digital world. global and borderless.
Comprehensive Review of Kaphaja Yonivyapath: Etiology, Diagnosis and Management Strategies
Authors: Ashok Lamani  , Ramadevi G
Published: April 2024

A family's health is guaranteed by a healthy woman. Ayurveda and contemporary medicine have both discussed the idea of a healthy yoni at various stages of a woman's life, from adolescence to menopause. These days, vaginal infections are a major concern for people of all ages and socioeconomic backgrounds. Because women have a special role of giving birth, gynecological illnesses have gained enormous relevance in the medical field. The majority of gynecological problems are included under the word "Yonivyapad," which is used in Ayurveda to refer to women's health care. Among 20 Yoni Vyapath’s Kaphaja yonivyapath is the one which is due to vitiation of Kapha, this vitiated Kapha reaches the Yoni Pradesha causes signs and symptoms like Kandu, Picchila Srava and Alpa Vedana as well as Sthanika and Sarvadaihika Kapha Prakopa Laxana. The treatment of Kaphaja Yonivyapath explained in classic as Kapha hara Dravyas and Shodhana Chikitsa mainly Vamana is indicated. This can be correlated with vulvovaginitis which is caused due to bacterial vaginosis, moniliasis and trichomans vaginalis. In this review an attempt has been made in this work to provide a conceptual analysis that covers nearly all of the Nidana, Samprapti and Chikitsa of Kaphaja Yoni Vyapad according to both Ayurveda and modern.
Varieties of Classical Drug Kadamba
Authors: Singh Sanjeev Kumar  , Mishra Hari Shanker  , Agarwal Ajay  , Shukla Anil Kumar
Published: April 2024

Kadamb an indigenous plant described in classical texts of Ayurved has a wide range of therapeutic potential. In Charak Samhita, it has been classified in the group of drugs indicated in the management of pain (Vednasthapan Mahakashya). Among various indications, it has been reported to be used in the treatment of vitiated semen, as an astringent in healing of fractured wounds, hemorrhagic conditions, dyslipidaemia, diseases of female genital tract, as complexion promoting and alexipharmic. In classical texts, at least four varieties of Kadamb have been described. There has always been some controversy regarding botanical identity of different varieties of Kadamb described in classical texts. Present paper is a serious attempt towards establishment of botanical identities of different types of Kadamb described in classical text of Ayurved on the basis of exploration of literature substantiated by observations of field survey.
Anticoagulant Activity of Ethanol Extract Arcangelisia Flava ( L. ) Merr
Authors:   Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Cenderawasih University, Jayapura, Indonesia, Lailatul Fitria , Asmuruf Frans ,   Department of Chemistry, Faculty of Mathematics and Natural Sciences, Cenderawasih University, Jayapura, Indonesia, Simaremare Eva Susanty ,   Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Cenderawasih University, Jayapura, Indonesia, Jannah Laila Roikhatul ,   Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institute Technology of Bandung, Indonesia, Yabansabra Yuliana Rut ,   Department of Chemistry, Faculty of Mathematics and Natural Sciences, Cenderawasih University, Jayapura, Indonesia
Published: April 2024

Many types of plants can be used as medicinal plants, one of which is the Arcangelisia flava plant (L.) Merr (A. flava). According to the people of Maribu-Sentani-Papua, A. flava is used as medicine for antimalarial, jaundice, and diabetes. This study aims to determine the anticoagulant activity of A. flava ethanol extract using the Lee-White method. This research uses human blood with blood groups A, B, O, and AB who do not have blood coagulation disorders. Tests were carried out each with 5 treatments with two replications. The first treatment was carried out on blood as a control, the second treatment was on blood treated with ethanol, the third treatment was on blood treated with EDTA, the fourth treatment on blood given EDTA and A. flava extract, and the fifth treatment on blood given A. flava test extract. The results of the study showed that A. flava extract using a concentration of 150 ppm did not have an anticoagulant effect on human blood groups A, B, O, and AB.
Enhancing Tourist Experience in Butuan City: Integrating Balangay Heritage as an Ancillary Service in Accommodation Facilities
Authors:   Father Saturnino Urios University, Butuan City, Philippines, A. Sitones Mark Lennon , P. Romano Nephi ,   Father Saturnino Urios University, Butuan City, Philippines, M. Joven Eda Lynne ,   Father Saturnino Urios University, Butuan City, Philippines, L. Avenido Meljean Rose ,   Father Saturnino Urios University, Butuan City, Philippines
Published: April 2024

In the competitive landscape of the global hospitality industry, differentiating accommodation services through innovative offerings is essential. This study explores the integration of Balangay heritage into the guest experience at accommodation facilities in Butuan City, aiming to enrich the tourist experience. Employing the H.du Cros model, the research evaluates the market attractiveness and robustness of Balangay heritage as a potential ancillary service. Surveys conducted with guests at various accommodations in Butuan City and interviews with hotel management and city tourism officials serve as the primary data sources. Results reveal that Balangay heritage exhibits moderate robustness and high market appeal, with 70.3% of respondents endorsing its integration as an ancillary service. Despite its promise, challenges related to the management and organization of the heritage attraction are identified. To address these issues, the study proposes a strategic framework for stakeholders, aiming to streamline the effective integration of Balangay heritage and thus enhance the tourist experience in Butuan City. This approach offers valuable insights into the synergy between heritage preservation and hospitality innovation, underscoring the potential for cultural heritage to enrich the tourism offering.
The Moderation Effect of Non-Performing Loans on Camel and Banking Performance in Indonesia
Authors:   Warmadewa University Master of Management Study Program, Dewi Ni Komang Desyana Supan , Ningsih Ni Luh Anik Puspa ,   Warmadewa University Master of Management Study Program, Siramiati Ni Wayan ,   Warmadewa University Master of Management Study Program
Published: April 2024

This research aims to determine the moderating effect of non-performing loans on cash and banking performance in Indonesia listed on the Indonesian stock exchange. Sample selection was carried out using a purposive sampling method, resulting in a sample of 195 with an observation period of 5 years from 2018 to 2022. This research uses quantitative data and the data used is secondary data obtained from the financial balance report of the Indonesia Stock Exchange. The techniques used in this research are multiple regression analysis and moderate regression analysis (MRA). The results of this research show that CAR and BOPO have a negative and statistically insignificant effect on profit growth. KAP, Liquidity, LDR have a positive and statistically insignificant effect on profit growth. ROA has a positive and statistically significant effect on profit growth. NPL does not moderates the relationship between liquidity and LDR on profit growth.
Economic Growth Vs. Poverty in Indonesia: What has Happened?
Authors:   IAIN Syekh Nurjati, Cirebon – West Java, Maryam Asmiyati Khusnul , Yusuf Ayus Ahmad ,   IAIN Syekh Nurjati, Cirebon – West Java, Sudrajat Anton ,   IAIN Syekh Nurjati, Cirebon – West Java
Published: April 2024

West Java is one of Indonesia’s three biggest contributors to GDP. The rate of economic growth in the province is also the highest on the island of Java, but it does not make West Java free from poverty. The fact, this smart province is the second poorest province nationally. The purpose of this study is to estimate the relationship and influence between economic growth, inequality, and poverty in West Java province using panel data. This study also analyses the characteristics of West Java’s economic growth using the Growth Incidence Curve (GIC). The panel data consists of combination of time series and cross section data from 2013-2022 period, based on information from 27 districts in West Java province. The estimation model employed in this study is panel regression model utilizing Random Effect Model (REM). The results of the study reveal a negative and significant effect of the economic growth on poverty. Furthermore, the inequality variable has a positive and significant impact on poverty. Based on GIC, West Java’s economic growth has not been pro-poor yet from the 2012-2022 period.
Moderating the Impact of E-Commerce Challenges on Adoption: Examining the Moderating Role of General Business Experience in Western, Sierra Leone SMES
Authors:   PhD Student: Enterprise Management, Capital University of Economics and Business, Beijing, China., Monson Fred Konneh Songa , Macauley Chrispus Charles ,   Msc Student Telecommunications Management and Administration, Njala University, Sierra Leone.
Published: April 2024

Purposes The study seeks to examine how SMEs in the Western Area are impacted by e-commerce adoption challenges. Moderating role of general business experience. Research methodology Descriptive and inferential statistics were used in the study's quantitative research methodology to reveal complex patterns and relationships. Respondents to a web-based survey using respondent-driven sampling included consultants, IT professionals, and business owners. Underlying patterns and model structure were identified using the Partial Least Square (SEM PLS) method of structural equation modeling in conjunction with path analysis and exploratory factor analysis. Conclusion The study reveals a strong positive relationship between e-commerce challenges and adoption rates, with higher challenge levels leading to higher adoption rates. Improved business experiences moderate the impact of e-commerce obstacles. The study emphasizes the importance of addressing e-commerce challenges and utilizing business experience to promote adoption among SMEs in Western Sierra Leone. Policy implication This paper highlights the need for improved infrastructure, technology accessibility, and digital literacy for SMEs in Western Sierra Leone, recommending specialized training, evidence-based policies, and a comprehensive strategy.
Perancanaan Strategis SI/TI Menggunakan Framework Ward and Peppard Pada Sekolah Kristen
Authors: Triady Sevilla , Andry Johanes Fernandes
Published: April 2024

Penerapan teknologi informasi serta sistem informasi saat ini menjadi faktor yang sangat diperlukan dalam organisasi, Perkembangan teknologi informasi sebagai bagian dari SI dan ilmu pengetahuan sudah mempengaruhi banyak bidang, salah satunya adalah bidang pendidikan yaitu sekolah. Sekolah Kristen adalah organisasi pendidikan yang proses belajar mengajarkan berdasarkan alkitabiah. Sekolah kristen telah menggunakan beberapa perkembangan TI pada proses bisnisnya. Namun penggunaan teknologi ini belum maksimal. Penelitian ini akan melakukan perancangan strategis sistem informasi menggunakan framework ward and peppard dengan analisis pendukung seperti value chain, SWOT, CSF, dan McFarland’s Strategic Grid. Framework ini dapat membantu organisasi menganalisis bisnis dan teknologi dari sisi internal dan eksternal organisasi. Penelitian ini dilakukan dengan tujuan meningkatkan penyelarasan strategi dan SI/TI untuk menghasilkan portofolio aplikasi. Hasil akhir dari penelitian adalah aplikasi usulan yang disesuaikan dengan proses bisnis dan kebutuhan bisnis dari sekolah Kristen yang diharapkan dapat menyelaraskan proses bisnisnya dan tercapainya tujuan bisnis.
Perancangan Sistem Informasi menggunakan TOGAF Dan Analisis Ward & Peppard pada SMA Santo Leo
Authors: Yefta Vlavio Nathanael , Bernanda Devi Yurisca
Published: April 2024

SMA Santo Leo merupakan sekolah swasta dengan jenjang SMA yang dinaungi oleh yayasan Santo Leo dan berlokasi di Jakarta Barat, DKI jakarta. Keseluruhan aktivitas bisnis yang berjalan saat ini belum memaksimalkan penggunaan teknologi secara penuh, sehingga sering kali terjadi permasalahan seperti kesulitan dalam mengumpulkan, mengurutkan, serta mengorganisir data-data. Tujuan penelitian ini adalah membantu SMA Santo Leo untuk mengembangkan arsitektur sistem informasi untuk menyelaraskan teknologi informasi dengan kebutuhan bisnis. Metode pengumpulan data yang digunakan yaitu observasi, studi literatur, dan wawancara. Pengembangan arsitektur sistem informasi dibantu menggunakan TOGAF dan analisis Ward & Peppard untuk mengidentifikasi kebutuhan dan menentukan strategi bisnis. Penelitian ini menghasilkan rancangan blueprint yang berupa rekomendasi usulan sistem informasi dan teknologi sehingga dapat membatu keseluruhan proses bisnis yang ada.
Implementasi Stack dan Array pada Pengurutan Lagu dengan Metode Selection Sort
Authors: Putri Ghina Mawarni , Pradja Kimberly Alfa Di , Azizi Muhammad Bilal Mardhiyyano , Nurwahid Prihatma , Perdana Abdi Surya , . Munawir
Published: April 2024

Lagu merupakan karya seni gabungan antara seni suara yang di dalamnya terdapat melodi dan warna suara penyanyi dengan seni bahasa. Banyaknya lagu sekarang ini maka diperlukan sebuah program yang bisa mengurutkan lagu agar memudahkan pengguna dalam pencarian lagu. Artikel ini bertujuan untuk menerapkan struktur data stack dan array pada pengurutan lagu dengan metode algoritma selection sort dengan harapan dapat mempermudah pengguna dalam menemukan lagu. Selain itu, artikel ini bertujuan untuk membandingkan apakah algoritma selection sort lebih cepat daripada insertion sort ataukah sebaliknya. Dalam pembuatan jurnal ini dilakukan metode penelitian studi literatur untuk memperdalam materi yang akan digunakan pada proyek. Adapun hasil program yang telah dibuat yaitu pengguna dapat memilih antara menambahkan lagu, mencari lagu, menampilkan lagu yang sudah ada dalam daftar, mengurutkan lagu, dan keluar dari program. Dengan ini pengguna dapat mengakses dan menambahkan lagu favorit mereka dimanapun dan kapanpun. Simpulan dari hasil yang didapatkan yaitu bahwa selection sort lebih cepat daripada insertion sort.
Sistem Informasi Layanan Tiketing yang Responsif dan Adaptif Berbasis Online
Authors: Maulana Muhammad Fahri , . Suprianto , Taurusta Cindy
Published: April 2024

Penggunaan teknologi informasi dalam industri event organizer menjadi krusial dalam meningkatkan efisiensi dan kualitas layanan tiketing. Penelitian ini membahas implementasi Sistem Informasi Layanan Tiketing yang responsif dan adaptif berbasis online pada Event Organizer FEST. Tujuan penelitian ini adalah untuk meningkatkan responsivitas sistem dalam menangani volume pengguna yang tinggi, serta memastikan adaptabilitasnya terhadap kebutuhan perubahan dalam industri event. Dengan implementasi Sistem Informasi Layanan Tiketing yang responsif dan adaptif, diharapkan dapat meningkatkan efisiensi proses penjualan tiket online, meningkatkan kepuasan pelanggan, dan membantu Event Organizer FEST dalam mengelola berbagai aspek kegiatan mereka dengan lebih efektif. Penelitian ini memberikan kontribusi positif terhadap pengembangan teknologi informasi di bidang layanan tiketing online dan dapat dijadikan referensi bagi industri event organizer lainnya.
Analisis Karakteristik Disturbansi Frekuensi 9 – 150 Khz Pada Sistem Photovoltaic Terhadap Tipe Beban Induktif
Authors: Muhammad Nagib , Utami Budi , Setiana Hatib
Published: April 2024

Pembangkit Listrik Tenaga Surya (PLTS) mengkonversi energi cahaya menjadi energi listrik dengan menggunakan photovoltaic. PLTS menggunakan inverter untuk merubah listrik DC ke AC untuk dapat dihubungkan ke beban AC. Seiring dengan meningkatnya penggunaan rooftop PLTS, maka penggunaan inverter juga meningkat. Faktanya, inverter dapat menghasilkan disturbansi pada frekuensi 9-150kHz. Berdasarkan hal tersebut, studi ini difokuskan dengan melakukan observasi terhadap karakteristik disturbansi PLTS terhadap variasi radiasi matahari dengan tipe beban induktif pada rentang frekuensi dari 9 – 150 kHz. Diharapkan hasil pengamatan yang didapatkan bisa menjadi acuan untuk penelitian dalam menganalisis, memprediksi dan mengetahui efeknya terhadap sistem tenaga listrik. Metode yang digunakan pada pengamatan ini adalah pertama dengan melakukan pengamatan pada keluaran sistem photovoltaic yang dihubungkan dengan tipe beban induktif lalu mengamatinya pada variasi kondisi radiasi matahari. Berdasarkan pengamatan yang didapatkan, secara umum terdapat tiga frekuensi disturbansi dominan yaitu range 19-29kHz, 69-79Khz, dan 140-149kHz.
Implementasi Computer Vision untuk Terjemahkan Abjad Bahasa Isyarat SIBI pada Aplikasi Android
Authors: Arrozaq Ahmad Ghoni , , Latipah
Published: April 2024

Penelitian ini dilatar belakangi kendala masyarakat saat komunikasi dengan tunawicara, dengan tujuan mengimplementasikan computer vision untuk menerjemahkan bahasa isyarat SIBI ke teks melalui aplikasi Android. Pengumpulan data melibatkan wawancara dan studi literatur, dan untuk pengembangan sistem menggunakan metode agile. Front-end dibuat dengan Kotlin dan Jetpack Compose, sementara back-end menggunakan model TensorFlow dalam format .tflite. Hasil pelatihan model sendiri mencapai 88% akurasi. Aplikasi ini diuji dengan membandingkan hasil terjemahan manual. Pengujian menunjukkan akurasi 81.48% dalam ruangan terang, 76.92% dalam ruangan redup, dan 80.77% di luar ruangan. Saran untuk penelitian selanjutnya untuk meningkatkan akurasi di tempat dengan kondisi redup dengan memproses gambar menjadi negatif atau menambahkan fitur untuk menyalakan flashlight.
Perancangan Sistem Pembelian dan Analisis Barang Dagang Pada Divisi Household PT Puncak Prima Lestari
Authors: Virshella Vina , Herdyana Sylvi , Tanuel Frans , Loisa Julia
Published: April 2024

Dikarenakan adanya kebutuhan dalam mengatasi permasalahan pada suatu perusahaan, maka perlu adanya penerapan teknologi yang menjadi solusi bagi perusahaan. PT Puncak Prima Lestari merupakan perusahaan ritel yang memiliki berbagai cabang di Pulau Bangka dan Belitung. Masalah pada perusahaan ini yaitu pembelian barang yang dilakukan masih secara manual. Tujuan dari penelitian ini adalah untuk menghasilkan rancangan sistem pembelian dan analisis barang dagang. Metode pengumpulan data dan analisis data yang digunakan yakni deskriptif kualitatif yang terdiri dari analisis data wawancara dan pengumpulan studi literatur, sedangkan metode pengembangan solusinya yakni metode prototyping, dimana aplikasi yang akan dirancang berbasis desktop, sehingga menggunakan diagram UML untuk perancangan sistemnya. Analisis situasi bisnis dilakukan menggunakan analisis value chain dan porter’s five forces. Hasil penelitian ini berupa rekomendasi terkait sistem pembelian dan analisis barang dagang untuk membantu pihak perusahaan dalam memberikan sistem pembelian yang lebih efisien dan dapat memprediksi tingkat penjualan untuk pertimbangan perencanaan perusahaan dalam riset pasar.