bluuebunny/crossref_metadata_2025 huggingface dataset:
Circular Economy in Small and Medium Sized Enterprises—Current Trends, Practical Challenges and Future Research Agenda
Authors: Chakraborty Ayon , De Debashree , Dey Prasanta Kumar
Published: January 2025

Circular Economy (CE) has evolved as a philosophy to transform industrial supply chains to become greener to combat climate change issues. Countries target of achieving Net Zero will never be fulfilled unless along with larger organisations, small and medium-sized enterprises (SMEs) are decarbonized as more than 90% of World’s businesses are SMEs. Although recently there are many studies on SMEs sustainability practices and performance covering drivers, bottlenecks, and opportunities, the holistic approach for embedding circular economy and sustainability covering design, planning, implementation, and operations are missing. This research bridges this knowledge gaps by revealing trends and theories of circular economy adoption in SMEs. Additionally, the research derives the drivers/enablers, issues, and challenges, and determine strategies, resources, and competences for the CE adoption in SMEs. The study concludes with a consolidated framework comprising of factors and methods for CE implementation in SMEs. The entire research has been undertaken using secondary data analysis method through content analysis of 163 published articles in highly ranked peer reviewed journals.
In-silico Evaluation of Aging-Related Interventions Using Omics Data and Predictive Modeling
Authors: Fuellen Georg , Palmer Daniel , Fruijtier Claudia , Avelar Roberto A
Published: January 2025

A major challenge in aging research is identifying interventions that can improve lifespan and health and minimize toxicity. Clinical studies cannot consider decades-long follow-up periods, and therefore, in-silico evaluations using omics-based surrogate biomarkers are emerging as key tools. However, many current approaches train predictive models on observational data, rather than on intervention data, which can lead to biased conclusions. Yet, the first classifiers for lifespan extension by compounds are now available, learned on intervention data. Here, we review evaluation methodologies and we prioritize training on intervention data whenever available, highlight the importance of safety and toxicity assessments, discuss the role of standardized benchmarks, and present a range of feature processing and predictive modeling approaches. We consider linear and non-linear methods, and automated machine learning workflows. We conclude by emphasizing the need for explainable and reproducible strategies, the integration of safety metrics, and the careful validation of predictors based on interventional benchmarks.
Phage-Based Biocontrol of Antibiotic-Resistant Enterobacter cloacae Complex in Fresh Produce
Authors: Pintor-Cora Alberto , Carpintero Andrea , Alegría Ángel , Giannis Apostolos , Lopez-Díaz Teresa M. , Santos Jesús A. , Rodríguez-Calleja Jose M.
Published: January 2025

The presence of opportunistic pathogens, such as the Enterobacter cloacae complex (ECC), in fresh vegetables poses a significant health risk, particularly amid the ongoing antibiotic resistance crisis. Traditional chemical decontamination methods are often ineffective and associated with issues such as cross-resistance between antibiotics and biocides, highlighting the need for alternative approaches. This study describes the isolation of a novel phage, FENT2, with anti-ECC activity, obtained from wastewater. Belonging to the Seunavirus genus, FENT2 did not carry genes associated with lysogenic cycle, antimicrobial resistance, or virulence factors. The phage demonstrated lytic activity against the host strain E. kobei AG07E strain, which harbors the mcr-9 gene. FENT2 exhibited a broad host range, infecting 82.6 % of ECC strains tested. In vitro assays using BioTrac (SY-LAB) technology confirmed the phage's efficacy, maintaining lytic activity under food-related stress conditions (pH levels from 5 to 7 and % NaCl up to 2). Furthermore, FENT2 demonstrated bactericidal potential on lettuce leaves, achieving an approximate 1 log reduction in bacterial counts of the host strain after immersion treatment. This study highlights FENT2 as a promising biocontrol agent in the food industry, providing an effective and sustainable alternative to traditional chemical decontamination methods.
Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance
Authors: Su Yanyu , Li Yi , Yi Qiaolian , Xu Yingchun , Sun Tianshu , Li Yingxing
Published: January 2025

Antifungal resistance poses a critical global health threat, particularly in immuno-compromised patients. Beyond the traditional resistance mechanisms rooted in heritable and stable mutations, a distinct phenomenon known as heteroresistance has been concerned, wherein a minority of resistant fungal cells coexist within a predominantly susceptible population. It may be induced by pharmacological factors or non-pharmacological agents. The reversible nature of it presents significant clinical challenges, as it can lead to undetected resistance during standard susceptibility testing. As heteroresistance allows fungal pathogens to survive antifungal treatment, this adaptive strategy often leads to treatment failure and infection recurrence. Though extensively studied in bacteria, limited research has explored its occurrence in fungi. This review synthesizes the current findings on antifungal heteroresistance mechanisms, highlighting the clinical implications of fungal heteroresistance and the pressing need for deeper mechanism insights. We aim to combine the latest research advances in the field of antifungal heteroresistance, summarizing in detail the characteristics, inducing factors, molecular mechanisms, and clinical significance of it, and describing the similarities and differences between heteroresistance, tolerance and persistence. Further research is essential to elucidate this phenomenon and develop more effective antifungal therapies to combat fungal infections.
COVID-19 Control in Philippine Highly Urbanized Cities: Utilizing Public Health Open-Source Government Data for Epidemic Preparedness and Response
Authors: Otero Maria Catherine B. , Bernolo Lorraine Joy L. , Miguel Refeim M. , Regencia Zypher Jude G. , Murao Lyre Anni E. , Baja Emmanuel S.
Published: January 2025

Highly Urbanized Cities (HUCs) in the Philippines were at the forefront of public health surveillance and response during the COVID-19 pandemic response. With the rapid spread of COVID-19 to Philippine cities, local government units continuously assessed, adapted, and implemented public health interventions (PHIs), and depended on available open-source government data (OSGD). This study consolidated PHIs in selected HUCs in the Philippines using high quality OSGD to create a timeline of interventions and document good practices in local COVID-19 control. OSGD resources were collected from February 2020 to January 2023, and data quality of OSGD was evaluated using the JAMA benchmarks. A total of 180 metadata sources were included in the analysis. All OSGD sources achieved at least two core standards with a mean (±SD) JAMA score of 3.03 (±0.90) indicating these are high-quality resources. COVID-19 control strategies were analyzed vis-à-vis the rise of COVID-19 cases and types of PHIs, including control of imported cases, case management, contact management, behavioral modification, and pharmaceutical intervention. Travel bans and hard lockdowns in Luzon early in the pandemic delayed the introduction of COVID-19 to other parts of the country. Good practices of LGUs for local COVID-19 control, such as quarantine passes, curfews and liquor bans, using QR-based contact tracing, massive community testing in high-risk communities, and free public swabbing centers, were implemented to slow down the local spread of COVID-19. The COVID-19 pandemic has shown the importance of OSGD for community and public health, especially for quick action and control, and post-pandemic assessments. Lessons learned must be integrated in epidemic preparedness and response programs against future emerging or re-emerging infections.
Gender Equality within the Sports Legal Framework: A Comprehensive Analysis and Future Perspectives
Authors: Alessi Longa Francesco
Published: January 2025

Gender equality within the realm of sport has become an increasingly prominent issue in discussions surrounding social and economic disparities. Despite notable advancements in international, European, and national legislation, gender-based discrimination persists across various domains, including representation, opportunities, and financial resources. This article delves into the legal infrastructure that underpins gender equality within the sports legal system, analyzing relevant international frameworks, as well as initiatives from European and national bodies. The article further explores the ongoing challenges faced by female athletes, such as wage gaps, media visibility, and career progression. A key focus is placed on efforts to foster inclusivity and equality, particularly through awareness-raising campaigns and policies aimed at supporting women in sport. The article concludes by offering a critical reflection on the gradual pace of change and underscores the necessity for collective action in dismantling the cultural barriers that continue to hinder the full participation and representation of women in sport.
Revisiting the Identity Principle of Quantum Mechanics
Authors: Li Suyu , Liang Canneng , Jin Mingxing
Published: January 2025

Identity principle is a fundamental postulate of quantum mechanics. In this paper, from a philosophical point of view, we revisit the identity principle of quantum mechanics. We attribute the identity to the existence of a precision limit for observation: the microscopic objects become indistinguishable when the difference between them is lower than the precision limit. This precision limit is determined not by the measuring apparatus, but by the action quantum h behand the objective physical law. We deduce logically how to relate the identity principle with the probabilistic interpretation, uncertainty principle, quantization in quantum mechanics, attempting to sorting out some logic for quantum theory. The indistinguishability of identical particles makes it impossible to accurately obtain all the details about the microscopic objects at the same time, and consequently the microscopic objects can only be described statistically, leading to the probabilistic determinism and indeterminacy of initial state in quantum mechanics. By reviewing Bohmian mechanics, one of the nonlocal hidden variable theories, we discuss the possibility of restoring determinism and causality in quantum mechanics by restoring the determinacy of initial state. However, any hidden variable theory constructed by using only the terminologies of classical physics cannot reproduce the quantum mechanical predictions. It is the identity principle that makes it impossible to restore causality and determinism, and is the root that makes quantum mechanics different from classical physics. Finally, the boundary between the so-called classical and quantum worlds is discussed. We hope these philosophical arguments can provide a kind of epistemic understanding for quantum mechanics.
Unraveling the Mechanistic Basis for Control of Seed Longevity
Authors: Li Zhonghai
Published: January 2025

Seed longevity, which holds paramount importance for agriculture and biodiversity conservation, continues to represent a formidable frontier in plant biology research. While advances have been made in identifying regulatory elements, the precise mechanisms behind seed lifespan determination remain intricate and context-specific. This comprehensive review compiles extensive findings on seed longevity across plant species, focusing on the genetic and environmental underpinnings. Inter-species differences in seed lifespan are tied to genetic traits, with numerous SEED LONGEVITY-ASSOCIATED GENEs (SLAGs) uncovered. These SLAGs encompass transcription factors and enzymes involved in stress responses, repair pathways, and hormone signaling. Environmental factors, particularly seed developmental conditions, significantly modulate seed longevity. Moreover, this review deliberates on the prospects of genetically engineering seed varieties with augmented longevity by precise manipulation of crucial genetic components, exemplifying the promising trajectory of seed science and its practical applications within agriculture and biodiversity preservation contexts. Collectively, our manuscript offers insights for improving seed performance and resilience in agriculture's evolving landscape.
E2CD86 Subunit Vaccine-induced Protection Against CSFV Requires IFN-γ-driven Cellular Immune Response
Authors: Wang Li-Yun , Chen Yu-Chieh , Chen Chi-Chih , Huang Yu-Chi , Chaung Hso-Chi , Chen Ya-Mei
Published: January 2025

Background: The study of specific T-cell responses to vaccines against CSFV is important for understanding long-term immunity and infection management. The administration of a subunit vaccine against swine pathogens has been demonstrated to be safe and effective in infected pigs. However, subunit vaccines usually need an effective immunomodulatory adjuvant to stimulate active immune responses. Objectives: CD86 plays a crucial role in the immune response by enhancing the ability of APCs to stimulate the maturation and activation of T lymphocytes. Therefore, CD86 may act as a potential molecular adjuvant due to its ability to increase cytokine expression, which is protective against T-cell activation in pathogens. Methods: In this study, the CD86 coding sequence was linked with the CSFV E2 antigen sequence and then expressed in CHO cells for production of the fusion protein as an E2-CD86 vaccine. Commercial pigs aged 5–6 weeks were randomized into four groups: those inoculated with E2, E2-CD86, commercial Bayovac® CSF-E2 vaccines and the saline group. All animals were boosted 2 weeks after primary vaccination. Results: After vaccination, we evaluated the humoral response and compared it with that of T cells with the aim of correlating both types of responses and increasing CSFV-specific E2 antibody detection. The results revealed that the percentages of CD3+CD4+/CD8+, CD4+IL2+, IFNγ+ and CD4+CD8+ (DP) T cells among the PBMC 14 days after primary vaccination were significantly greater in the E2-CD86 group than in the other groups. The ELISpot results revealed a significant increase in the number of E2-specific IFNγ+ cells on D21 after vaccination. Conclusions: These results suggest that CD86 may enhance cellular immunity by increasing the levels of IL-2 and IFNγ-positive cells. Therefore, CD86 can act as a potential immuno-modulatory adjuvant in the development of subunit vaccines because of its protective efficacy.
Cinema, esporte e racismo: uma proposição pedagógica
Authors: Santos Maria Rute da Conceição dos , Santos Wolney Nascimento , Teles Perolina Souza , Zoboli Fabio
Published: January 2025

Este ensaio objetiva apresentar uma proposição didático-pedagógica para tematizar o racismo a partir do cinema tendo como pano de fundo o esporte. Tal aproximação é feita com a intenção de deslocar o esporte do estatuto dos gestos técnicos e regras para o campo da sétima arte para reflexionar o racismo. Para tal foram elencados dois filmes, “Raça (2016)” e “Ali (2001)”, que tematizam a discriminação racial sofrida por dois atletas negros. São obras que retratam as vidas de duas grandes lendas do esporte americano, o corredor Jesse Owens (1913-1980) e o pugilista Muhammad Ali (1942-2016). Acredita-se que a utilização de filmes com proposição didática descolonizadora, pautada pela Lei 10.639/2003, pode contribuir com a ressignificação da existência negra e por consequência, com o aniquilamento do racismo.
Giant ovarian cystadenoma and secondary infertility
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, A.I.Ishchenko A.I.Ishchenko , Davydov A.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ishchenko A.A. ,   Treatment and Rehabilitation Center, Moscow, Russian Federation, Khokhlova I.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Dzhibladze T.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Gadaeva I.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ageev M.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Komarova A.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Rossolovskaya K.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Chushkov Yu.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Budnikova K.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Samgurova D.E. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: January 2025

This article presents a clinical case of giant serous papillary cystadenoma in a 35-year-old patient with secondary infertility. The patient underwent successful surgical treatment, and reproductive potential was restored.
Key words: giant serous cystadenoma, secondary infertility, reproductive age, surgical treatment
Selection of in vitro fertilization program in patients with functional ovarian cysts
Authors:   Siberian State Medical University, Tomsk, Russian Federation, Timofeeva O.S. , Petrov I.A. ,   Siberian State Medical University, Tomsk, Russian Federation, Tikhonovskaya O.A. ,   Siberian State Medical University, Tomsk, Russian Federation, Logvinov S.V. ,   Siberian State Medical University, Tomsk, Russian Federation, Gaifulina J.F. ,   Siberian State Medical University, Tomsk, Russian Federation, Samoilova Iu.G. ,   Siberian State Medical University, Tomsk, Russian Federation, Kudlay D.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   Lomonosov Moscow State University, Moscow, Russian Federation, Petrova M.S. ,   Siberian State Medical University, Tomsk, Russian Federation, Okkel Yu.V. ,   Siberian State Medical University, Tomsk, Russian Federation, Dmitrieva M.L. ,   Siberian State Medical University, Tomsk, Russian Federation
Published: January 2025

Objective. To compare the clinical efficacy of in vitro fertilization (IVF) programs in patients with functional ovarian cysts (FOC) depending on the treatment strategy (transvaginal aspiration of cysts or use of gonadotropin-releasing hormone (GnRH) antagonists).
Patients and methods. This prospective randomized study included 99 reproductive-aged women. The study group (n = 66) comprised patients with anovulatory infertility and FOC. Two subgroups were also identified: group IA (n = 28) – patients who underwent pre-treatment with a GnRH antagonist; group IB (n = 38) – patients who underwent transvaginal cyst aspiration. After treatment, controlled ovarian hyperstimulation was administered according to a fixed GnRH antagonist protocol. In the comparison group, a standard IVF program was performed.
Results. If the cyst diameter is >4 cm, transvaginal aspiration is preferred; for smaller diameters, the use of GnRH antagonists is preferred. This mechanism is probably mediated by increased fluid pressure on the wall of the cyst >4 cm, which leads to thinning, up to complete exfoliation of the granulosa layer and hence loss of sensitivity to the effect of GnRH antagonist.
Conclusion. The main clinical criterion for choosing the optimal treatment strategy for FOC in assisted reproductive technology programs is the diameter of the ovarian cyst.
Transition from combined oral contraceptives to menopausal hormone therapy in women
Authors:   City Clinical Perinatal Center, Omsk, Russian Federation, Kravchenko E.N. ,   Omsk State Medical University, Omsk, Russian Federation
Published: January 2025

Transition from combined oral contraceptives (COCs) to menopausal hormone therapy (MHT) in women is a topical issue due to the increasing number of women of peri- and postmenopausal ages, which are associated with the development of pathological conditions, vasomotor symptoms, psycho-emotional and urogenital disorders. It is relevant to preserve the health and improve the quality of life of women, which is of medical and social importance. This article presents clinical cases demonstrating the efficacy of transition from COCs to MHT agents when menopausal symptoms appear with COC withdrawal and during the hormone-free period of COC use.
Key words: perimenopause, menopausal syndrome, menopausal hormone therapy, combined oral contraceptives
Prevention strategies for antibiotic resistance in obstetric and gynecologic practice
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Shikh E.V. , Khaytovich E.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: January 2025

This article considers the issues of antibiotic resistance prevention using dequalinium chloride (DQC) as an example. Antimicrobial resistance is a serious threat to global health due to natural adaptation mechanisms of microorganisms; it is complicated by irrational use of antimicrobial agents. DQC, which is a quaternary ammonium compound, has a broad spectrum of antimicrobial activity and is effective against gram-positive and gram-negative bacteria, fungi and protozoa. The absence of registered cases of resistance to DQC makes it a promising tool for the treatment of infections, including those resistant to conventional antibiotic therapy. The article presents the results of clinical trials confirming the high efficacy and safety of DQC in the treatment of vaginal infections and recurrence prevention. Special attention is paid to the need for further research to support these findings and to develop comprehensive strategies for the use of antiseptics in clinical practice.
Key words: dequalinium chloride, antibiotic resistance, bacterial vaginosis, antiseptics, pharmacotherapy
NON-PYROLYTIC FIELD METHOD FOR THE PRODUCTION OF RESINOUS WOOD TAR FROM MANGIFERA INDICA (MANGO TREE)
Authors:   Associate Professor, Department of Industrial Technology, School of Technology, Njala University, Sierra Leone., Syed Fofanah Mohamed
Published: January 2025

Resinous wood tar is a dark, viscous liquid of hydrocarbons and free carbon which is a by-product of the high temperature carbonization or pyrolysis of resin producing woods like pine and mango woods in anoxic conditions. Pyrolysis produces flue gases that contain pollutants, such as carbon monoxide, nitrogen oxides, and sulfur dioxide, which can pollute the air and water. This study provides an alternative technology for the production of wood tar using non-pyrolytic method which is comparatively a less complex process, save cost due to low energy consumption and mitigate environmental pollution. The two main objectives considered in the study were to determine the wood tar production efficiency of mango tree resin and some physical properties of the wood tar produced. The experimental method basically involves the immersion of the mango wood bark chips in water for 72 hrs so that the resin in the chips will adequately dissolve in water. The solution is boiled at 100oC to allow water to evaporate under controlled environment leaving a dark brown tarry concentrate. The 5000ml of resin solution obtained from the 5kg bark chips immersed in water yielded 300ml of liquid wood tar and 168g of concentrated wood tar. The wood tar produced has a pH of 4.37 (acidic) and density of 1.06g/cm3.
TRAUMA AND HISTORY IN SUSAN ABULHAWAS THE BLUE BETWEEN SKY AND WATER
Authors:   Research Scholar, Department of English, DrRafiqZakaria College for Women, Aurangabad., Batul Fatema Mubarak Pathan , Mahlaqa Khan ,   Research Guide, Department of English, DrRafiqZakaria College for Women, Aurangabad.
Published: January 2025

The present research paper deals with trauma and history in Susan Abulhawas novel The Blue Between Sky and Water. In the wake of current political conditions, literature has a responsibility to record history when history itself falls short. The middle-east has probably seen more political upheavals than any other region in the world. The Palestinian dilemma has become a matter of international concern. In the midst of it, writers like Susan Abulhawa have done a remarkable job of chronicling the trauma and suffering of the Palestinians. The fictional elements of her book embrace actual historical tragedies and portrays its consequences on the marginalized voices of the region. The psychological depth of her characters is explored through omniscient point of view in her novel The Blue Between Sky and Water.
ETUDE DE PERFORMANCE DUN NOUVEL ALGORITHME DE LOFDM ADAPTATIF POUR LA MONTEE EN DEBIT DANS LES RESEAUX DACCES OPTIQUES
Authors:   Departement de Genie Informatique et Telecomunications (GIT), Ecole Polytechnique dAbomey-Calavi (EPAC), Universite dAbomey-Calavi (UAC), Abomey-Calavi, Benin., O. Sanya M.F. , Magnidet F. ,   Departement de Genie Informatique et Telecomunications (GIT), Ecole Polytechnique dAbomey-Calavi (EPAC), Universite dAbomey-Calavi (UAC), Abomey-Calavi, Benin., B. Alonoumi Z.C. ,   Departement de Genie Informatique et Telecomunications (GIT), Ecole Polytechnique dAbomey-Calavi (EPAC), Universite dAbomey-Calavi (UAC), Abomey-Calavi, Benin., Aupetit-Berthelemot C. ,   XLIM Dpt.C2S2 UMR-CNRS 7252, Universite de Limoges, 16 Rue Atlantis, 87068 Limoges France.
Published: January 2025

Orthogonal Frequency Division Multiplexing (OFDM) has demonstrated its effectiveness as a modulation technique in optical communication systems, where data is transmitted and received through optical channels. This paper proposes and implements a novel adaptive OFDM method, called Minimization E-Tighted (MET), aimed at enhancing the data rate in low-cost optical access network links. The implementation was carried out for a Time Division Multiplexing Passive Optical Network (TDM-PON) link, co-simulated using VPIphotonicsâ„¢ and MATLAB. Simulation results showed that for the simulated target BER values (10â»Â³ and 10â»â´), the data rates achieved with the MET method are nearly identical to those obtained using the Levin-Campello method, which is commonly employed for rate enhancement. With the simulated parameters at a target BER of 2.23Ã—10â»â´, it is demonstrated that 12 Gb/s data rate are achievable on a TDM-PON link with the MET method, supporting 64 users over a 60 km fiber span. Moreover, the MET method proved its capability to optimize the data rate for any given target BER value. Finally, the study revealed that employing high-resolution DAC/ADC converters can further increase the links data rate when the MET algorithm is used.
Reflexiones de desarrollo familiar frente a las nuevas formas de convivencia
Authors: Ospina García Alexander , Trejos Ladino María Luisa
Published: January 2025

El presente escrito permite reflexionar frente a las nuevas formas de convivencia de las familias en el mundo a través de una metodología cualitativa con enfoque reflexivo propuesto en la asignatura de Modernidad, Modernización y Familia del Departamento de Estudios de Familia de la Universidad de Caldas en Manizales, Colombia, por medio de la revisión de textos, discusión argumentativa y encuentro a voces es que se presentan los resultados que muestran desde una lectura del Desarrollo Familiar Colombiano la transición de la familia nuclear, tradicional, laica y católica hacia nuevas formas de convivencia en familia que representan el cambio familiar en su organización económica, prácticas de cuidado, crianza y socialización y en suma, las relaciones familiares permeadas por momentos que dan cuenta de su diversidad y pluralidad. A modo de conclusión, se genera una discusión de las tipologías familiares desde sus dinámicas internas para pensar en las necesidades actuales de las familias y el llamado a las nuevas formas de convivencia en el mundo.
Dinámica interna y externa familiar de jóvenes de la subregión del Urabá Antioqueño - Colombia
Authors: Luis Diaz Peñata Jaime , Herrera Rivera Ovidio
Published: January 2025

El artículo analiza factores de la dinámica interna y externa familiar con afectación en el comportamiento de jóvenes colombianos, oriundos de la Subregión del Urabá Antioqueño. El rastreo de información contó con fuentes teóricas de apoyo extraída de bases especializadas en el tema. Como hallazgo principal se identificó que factores propios de la dinámica interna familiar, cuando se les da un manejo inadecuado por parte de los padres, entre ellas prácticas autoritarias y violentas, normas y lintes poco claros, al igual que un marcado ausentismo parental, generan detrimento en el comportamiento juvenil, aspecto que puede inducir a prácticas delincuenciales y violentas. Por su parte las dinámicas externas, sociales, políticas y económicas, generan impacto en la población juvenil, con beneficios, cuando ayudar a dinamizar sus proyectos de vida, o en detrimento, al resultar lesivas para el desarrollo de estos intereses. El estudio aporta elementos conducentes a la mejora de acciones en las políticas públicas juveniles, que tributen por el bienestar de jóvenes y sus familias en esta subregión del país y de otros departamentos colombianos con problemáticas afines.
«Miseria del psicoanálisis». Respuesta a la investigación psicoanalítica contemporánea
Authors: Gallardo Núñez Tonatiuh
Published: January 2025

En el presente artículo analizo dos publicaciones psicoanalíticas recientes y extraigo algunas conclusiones sobre los vicios que no solo denotan el campo del psicoanálisis; sino que permiten entrever cómo dogmas heredados y descuidos injustificados terminan por desterrar la producción psicoanalítica del campo del conocimiento científico (cuestión fundamental para Freud). Para el caso, menciono dos sencillas prácticas académicas que permitirían retomar el camino y que, por evidentes y tal vez engorrosas, se han terminado por desestimar. El rigor y orden en el razonamiento, aunque tedioso y ajustado, permite ceñir los esfuerzos epistémicos en pos del avance del conocimiento. Si bien la investigación psicoanalítica se diferencia de las demás disciplinas científicas en cuanto a su método y su objeto; la forma persiste. Los torrentes de asociaciones no por intentar estar encadenadas poéticamente se alejan del delirio; al contrario, hacen del extravío su meta. Termino mencionando otras dos publicaciones psicoanalíticas recientes; estas sí, ejemplares de cómo realizar correctamente una investigación científica en el terreno psicoanalítico.
Theory of mind: network of complex processes woven into the intersubjective experience
Authors: Bedoya-Gallego Diana Marcela , González-Gaviria Maira Alejandra , Palacio-Sañudo Jorge Enrique
Published: January 2025

This paper aims to contribute to the reflection that expands and makes explicit the aspects of early motherchild bonding that favor the development of Theory of Mind (ToM). For this purpose, first, we start from the conceptualization of ToM and its understanding from the Theory of Theories and Simulation Theory, as they have been identified as the most important theoretical models that explain one of the most relevant differential capacities of the human species. Subsequently, it is proposed that this capacity emerges in the bonding context, since due to its complexity it constitutes an evolutionary advantage that favors the establishment of the social bond; for this purpose, the developments of the Attachment Theory are used. The content analysis carried out allows us to recognize that treating the child as a mental agent (intentional and with individuality) and tending to use terms of mental state in discourse, play a fundamental role in the development of children’s capacity to understand other minds, so that rather than entering into the debate of internalist or externalist perspectives on the development of ToM, the value of intersubjective experience is highlighted.
Experience of the covid-19 phenomenon in the context of marital and parent-child relationships
Authors: Cabrera García Victoria Eugenia , Erasmus Guedez Darlaine Betzabeth , Jiménez Muñoz Junny Stefany , Docal Millán María del Carmen
Published: January 2025

The COVID-19 pandemic has brought major changes on family relationship worldwide and the mandatory isolations made the development of home schooling and work a must. Objective: To explain marital conflict based on anxiety, parental stress, rough handling of children and the accompaniment of parents in their children’s school activities during confinement by COVID-19. Method: Descriptive, explanatory, mixed study, through questionnaire and interview. The Study was carried out in a sample of 899 Colombian and Aruban people. Results: the variable that weighted the most in women in Colombia was parental stress. In men it was anxiety which makes a greater contribution to marital conflict, followed by parental stress. In Aruba, the only variable that contributed significantly was parental stress. In both countries, a positive correlation with anxiety, parental stress and rough treatment. However, a negative correlation was found with the accompaniment of the children’s school activities. Conclusions: The pandemic increased marital conflicts, due to anxiety, parental stress, which sometimes generated rough handling of children and the spouse.
Sentipensar y cosmopercibir con las comunidades afrodescendientes: el desafío de la universidad en Colombia
Authors: Parra Valencia Lliana
Published: January 2025

El artículo de reflexión problematiza el racismo y la desigualdad que vivencian las personas negras en la educación superior en Colombia y rastrea las acciones afirmativas de carácter racial. Evoca saberes otros africanos, afrodiaspóricos e indígenas y sus aportes al conocimiento, en una historicidad que la racionalidad moderna/colonial excluyó. Así como también las prácticas/sabidurías ancestrales que circulan de forma continua en los territorios y, desde otras pedagogías, mantienen vivos los saberes afrodiaspóricos. Este concluye con reflexiones para repensar la universidad e invita al sentipensar para unir cabeza y corazón, y, a las cosmopercepciones, desde los análisis epistemológicos y ontológicos de diversos modos de conocer, ser y existir desde los territorios ancestrales.
Estructura de trabajos de investigación para grado en programas de maestría en profundización de las ciencias administrativas
Authors: Barrera Lievano Jhony Alexander , Beltrán Virgüez Jesús , Parada Fonseca Sandra Patricia
Published: January 2025

Según el Ministerio de Educación Nacional (MEN), en Colombia las maestrías en profundización tienen como propósito ampliar y desarrollar conocimientos, habilidades y actitudes en favor de la generación de soluciones a problemas disciplinares, profesionales o interdisciplinares o habilitar al estudiante como investigador. Para optar por la titulación, el maestrante debe realizar un trabajo de investigación. Dado lo anterior, surge la siguiente pregunta: ¿cuál es la estructura adecuada para un trabajo de grado de maestría en profundización en el campo de las ciencias administrativas? El objetivo principal es realizar una propuesta de estructura mínima adecuada para el desarrollo de trabajos de grado de maestrías en profundización del campo de las ciencias administrativas, que atienda los lineamientos dados por el MEN. Para ello, se desarrolla una investigación cualitativa con diseño de fenomenología empírica, se aplica la estrategia de triangulación de investigadores, con base en una muestra no estadística compuesta por profesionales expertos en la materia y se proponen estructuras de trabajos de grado acordes a las posibles salidas que indica el MEN, según lo evidenciado en la literatura y los datos primarios recolectados.
Confecção de um modelo 3D para ser usado como instrumento para a educação do tratamento de emergência de dente traumatizado
Authors: Mylena Sumocoski de França  , Liliane Roskamp  , Peterson Ricardo Dobruski-Júnior  , Andrei Correa Guandalini  , Maria Carolina Botelho Pires de Campos  , Flares Baratto-Filho  , Camila Paiva Perin  , Thaís Kauana Magalhães Sobral  , Thaís Vilalba  , Felipe Varaschin Theodorovicz  , Juliana Marodin Fauri Rotta  , Natanael Henrique Mattos
Published: January 2025

O manejo de primeiros socorros de um dente traumatizado possui influência direta no seu prognóstico. Em alguns casos, quando ele não é realizado já no local do acidente, aumentam muito as chances de o indivíduo perder o dente em um curto prazo de tempo, em virtude da reabsorção radicular. Daí a necessidade de treinar o maior número de pessoas para realizar o manejo emergencial. Material e métodos: Foi desenvolvido um modelo em 3D da arcada superior com um incisivo central removível para a padronização de futuras imagens fotográficas e computadorizadas, no caso de confecção de vídeos educativos. Resultados: O modelo ficou resistente e fácil de ser manejado. Conclusão: O modelo ficou padronizado e apto para ser utilizado em futuras campanhas educacionais de traumatismo dentário.
Crosstalk: Biochemical Signatures and Clinical Implications in Rare Hereditary Hemolytic Anemias (Hereditary Spherocytosis)
Authors: Al Toub Faris Abdoullah , Hamzah Obaied Asseri Amer , Rafi Baig Mirza , R. Almalki Naif Abdullaha , Anwar Firoz
Published: January 2025

Background:

Clinical Hereditary Hemolytic Anemia (HAA) particularly Hereditary Spherocytosis
(HS) encompasses diverse genetic disorders causing premature red blood cell destruction and intrinsic RBC defects. There’s a pressing need for standardized diagnostic protocols tailored to the Asian population, particularly in Saudi Arabia, underscoring the significance of thorough blood biochemistry analysis.

Materials and Methods:

A case-control prospective study was conducted at King Abdulaziz University, samples were obtained from King Fahad, hospital Jeddah, Saudi Arabia, serving a significant population, and
blood samples from 27 patients meeting ethical criteria for HHA and HS. Inclusion criteria included diagnosed
patients of any age and sex, while exclusion criteria encompass chronic infections, metabolic diseases, pregnancy, and lactation. Blood profiling was conducted following strict protocols, aiming to glean insights into patients’ management and therapeutic strategies. Despite an intended larger sample size, limitations in availability led to the inclusion of 27 patient analyses.

Results:

Among 27 participants, males comprised 59.3%, females 40.7%. Anemia types indicated 22.2% Type
1 (HHA) and 77.8% Type 3 (HS). Age groups (<30, 31-59, ≥60 years) highlighted HS prevalence, notably in
older individuals. Blood pressure analysis revealed age-related increases, especially in those over 60 with systolic BP (147.33 ± 9.86 mm/Hg) (p≤0.02) and diastolic BP (85.67 ± 9.01 mm/Hg) (p≤0.03) emphasizing agespecific monitoring. Temperature variations were noted across ages, significant in patients over 60 (35.93 ±
1.100C) (p≤0.09), indicating potential clinical relevance. Iron levels showed no age-related differences, while
Blood Urea Nitrogen (BUN) levels rose with age, particularly in those over 60 (35.83 ± 16.67 mm/dL)
(p≤0.04), suggesting age-related influence. Alkaline Phosphatase levels increased with age, especially in patients aged 31 to 59 (205.80±123.17IU/L)(p≤0.001), warranting further investigation. Similarly, Aspartate
Transferase levels rose with age, especially in patients aged 31 to 59 (134.69 ± 284.58 U/L) (p≤0.01),), underlining age-specific considerations. Notable differences in BUN (15.03 mm/dL and 29.06 mm/dL)and Aspartate Transferase (33.01 U/L and 115.66 U/L) levels were observed among different anemia types with no major significant alteration in LDH.

Conclusion:

The results suggest unique biochemical signatures with potential renal and hepatic implications,
underscoring the importance of biochemical assessment in managing hereditary hemolytic anemias, particularly HS.
The Efficacy of Oral Atorvastatin for Skin Toxicity in Breast Cancer Patients Undergoing Radiotherapy: A Randomized, Double-blind, Placebo-controlled Trial
Authors: Danesh Mahmonir , Ghasemi Arash , Hamzehgardeshi Zeinab , Charati Jamshid Yazdani , Hosseinimehr Seyed Jalal
Published: January 2025

Introduction:

Most Breast Cancer (BC) patients undergoing Radiotherapy (RT) are potentially susceptible
to skin toxicity and prone to clinical symptom complaints. This study aimed to investigate the effect
of oral Atorvastatin (ATV) administration on skin toxicity in BC patients undergoing RT.

Methods:

One hundred BC patients were randomly assigned to oral ATV (40 mg) or placebo tablets two days
before beginning the RT until the eighth week of the RT regimen was completed. Radiation-induced dermatitis
was classified according to the Radiation Therapy Oncology Group (RTOG) criteria for eight weeks of
treatment. In addition, during the eight weeks of RT, the clinical symptoms, such as pain, itching, burning, and
sensitivity, were scored by patients in both groups according to the Visual Analogue Scale (VAS).

Results:

Ninety-four BC patients were analyzed in this study. At the end of the seventh week of RT, the between-
group analysis showed a statistically significant reduction of 20.7% in the ATV group (1.693 ± 0.846)
compared to the placebo group (1.900 ± 0.986, P=0.036). However, the comparison of the dermatitis grade in
the ATV and placebo groups showed a reduction of 54.5% in the ATV group; this difference was not statistically
significant (p = 0.072). The results of VAS regarding the clinical symptoms of patients showed pain, itching,
burning, and sensitivity to touch to be clinically decreased in the ATV group compared to the placebo
group in the 8 weeks, but these differences were not statistically significant.

Conclusion:

According to the results of this clinical study, the oral administration of ATV at a dose of 40 mg
during RT regimens can effectively reduce skin RT-induced toxicity and improve the self-report clinical symptoms
among BC patients.
3',4'-Dihydroxy Flavonol (DiOHF) Exerting a Positive Effect on Neurogenesis and Retinal Damage in Experimental Brain Ischemia-Reperfusion of Rats
Authors: Cetin Osman , Aladag Tugce , Acar Gozde , Onal Ummugulsum , Baltaci Saltuk Bugra , Mogulkoc Rasim , Baltaci Abdulkerim Kasim
Published: January 2025

Introduction:

Brain ischemia-reperfusion can cause serious and irreversible health problems. Recent
studies have suggested that certain flavonoids may help stabilize the correctly folded structure of the visual
photoreceptor protein rhodopsin and offset the deleterious effect of retinitis pigmentosa mutations.

Objective:

The current study aimed to determine the effect of 3',4'-Dihydroxyflavonol (DiOHF) supplementation
for 1 week on lipid peroxidation in the retina tissue following focal brain ischemia-reperfusion in rats.

Methods:

This study was carried out on male Wistar-albino rats. A total of 28 rats were used in the research,
and four groups were formed: Control group: no anesthesia or surgical procedure was applied to the animals in
this group, Sham group: after general anesthesia was established in the animals in this group, the carotid artery
areas were opened and closed, and the 1 ml vehicle was applied for 1 week, Ischemia-Reperfusion (I/R) group:
after the carotid arteries were isolated in rats under general anesthesia, ischemia was performed by ligating
them for 30 minutes, and then reperfusion was applied for 1 week, and Ischemia-Reperfusion + DiOHF group:
under general anesthesia, ischemia was developed in the carotid arteries of the rats by ligation for 30 minutes,
and then DiOHF was applied along with reperfusion for 1 week. At the end of the study, retinal tissue taken
from animals sacrificed under general anesthesia was analyzed for MDA and GSH. Retinal tissue was also examined
for histology and neurogenesis.

Results:

The highest MDA value was determined in the ischemia group, and the lowest value in the control
and sham groups. In group 4, this parameter was found to be significantly lower than in the I/R group. Retinal
GSH was very low in the I/R group. However, 1-week DiOHF treatment increased the GSH values. Deteriorations
also occurred in the histological structure of the retinal tissue, and neurogenesis was inhibited. However,
treatment improved retinal damage and neurogenesis.

Conclusion:

The results of the current study showed that focal brain ischemia in rats caused significant retinal
lipid peroxidation. However, 1-week DiOHF treatment suppressed the increased lipid peroxidation by increasing
GSH levels. Moreover, treatment improved retinal damage and neurogenesis.
Harmony in Motion: The Role of Exercise in Orchestrating Neuroprotection for Individuals with Alzheimer's Disease and Diabetes Examined from a Psychological Perspective
Authors: Zhang Dongzi , Khan Munir Ullah , Safir Ullah
Published: January 2025

According to epidemiological studies, diabetes is more common in patients with AD,
which suggests that diabetes is a significant risk factor for AD. Accelerating brain cell degeneration,
worsening cognitive decline, and increasing susceptibility to AD can be attributed to pathogenic
mechanisms linked to diabetes, such as impaired insulin signaling in the brain, neuroinflammation,
oxidative stress, mitochondrial dysfunction, and vascular impairment. These factors
can also lead to the accumulation of β-amyloid and tau protein phosphorylation. New research
suggests that certain drugs used to manage diabetes have different levels of effectiveness in
treating or preventing Alzheimer's disease. Exercise has numerous advantages, including the
reduction of neuroinflammation, alleviation of oxidative stress and mitochondrial dysfunction,
improvement of endothelial and cerebrovascular function, stimulation of neurogenesis, and prevention
of pathological changes associated with diabetes-related Alzheimer's disease through
various internal mechanisms. This study examined the development of Alzheimer's disease
(AD) in relation to diabetes, evaluated the ability of specific antidiabetic drugs to prevent and
treat AD, and investigated the impacts and underlying processes of exercise interventions in
improving AD treatment for individuals with diabetes.
Methyl-CpG-Binding Domain Protein 2 is Involved in Th17 Cell
Differentiation by Negatively Regulating Leptin Expression
Authors: Xia Yang , Zhang Xiufeng , Wu Dingjiang
Published: January 2025

Background:

Among Th lineages from naïve CD4+T cells, Th17 cells
producing IL-17 are strongly related to the pathogenesis of neutrophilic asthma. Leptin
is involved in inflammation and immunity. Little is known about MBD2's epigenetic
regulation in CD4+T cell differentiation

Objective:

Our study is intended to delve into the mode by which MBD2 interacts with
Leptin to govern Th17 cell differentiation.

Methods:

CD4+T cells were harvested from the spleen tissue of C57BL/6 mice. Th17
cell differentiation was determined by flow cytometry, and ELISA measured IL-17.
Western blot and RT-qPCR were employed to detect the expression of MBD2, Leptin
and RORγt. CO-IP was utilized to assess the relationship between MBD2 and Leptin

Results:

Under the overexpression or silencing of the MBD2 and Leptin genes, the
differentiation of Th17 cells, IL-17 secretion, and RORγt expression all manifested
positive changes. Leptin expression showed a positive variance upon overexpression
or silencing of the MBD2 gene; however, there was no significant disparity in the
expression of MBD2 under the overexpression or silencing of the Leptin gene. MBD2
can interact directly with Leptin.

Conclusion:

MBD2 is capable of inducing the differentiation of naïve CD4+T cells into
Th17 cells by augmenting the expression of Leptin.