bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of a Two-Tier Family-Oriented Intervention in Enhancing the Family Functioning and Care Capacity of the Family Caregivers of Stroke Survivors: Protocol for a Randomized Controlled Trial
Authors: Lou Vivian Weiqun , Tang Jennifer Yee Man , Lau Gary Kui Kai , Lum Terry Yat Sang , Fong Kenneth , Ko Rachel Wai Tung , Cheng Clio Yuen Man , Fu Joyce Yinqi , Chow Eddie Siu Lun , Chu Angus Chun Kwok , Hui Elsie , Ng Winnie Wing Ling , Chan Felix Hon Wai , Luk C C , Kwok T K
Published: April 2021

Background

Stroke has profound impacts on families. Often, family members, including stroke survivors and the person who takes up the role of the primary caregiver, would encounter demands on finances, rehabilitation arrangement, and even conflicts. Hence, a family-oriented intervention is expected to enable families to rebuild internal and external resources to achieve optimal rehabilitation and community reintegration.

Objective

This study aims to describe a design of a two-tier family-oriented care management intervention for enhancing the family functioning and care capacity of the caregivers of stroke survivors.

Methods

The two-tier care management intervention was guided by a standardized protocol conducted by trained professional care managers (first tier) with the support of trained volunteers (second tier), which lasted for 8-12 weeks. Participants were recruited through collaborating hospitals according to inclusion and exclusion criteria. In order to examine the effectiveness and cost-effectiveness of the two-tier care management intervention, a two-arm randomization multicenter study was designed, including an active comparison group, which was guided by a standardized protocol conducted by trained volunteers. Dyadic participants, including both stroke survivors and their primary caregivers for both groups, were invited to participate in a questionnaire survey using standardized and purposefully developed measures 3 times: before the intervention, immediately after the intervention, and 2 months after the intervention. The primary outcome was family functioning measured by the Family Role Performance Scale and Family Assessment Device-General Functioning Scale. The secondary outcomes included caregiving burden, depressive symptoms, care management strategies, and the incremental cost-effectiveness ratio.

Results

Recruitment began in January 2017 and was completed at the end of April 2019. Data collection was completed at the end of March 2020. As of March 2020, enrollment has been completed (n=264 stroke caregivers). A total of 200 participants completed the baseline questionnaires. We aim to publish the results by mid-2021.

Conclusions

This study successfully developed a two-tier care management protocol that aims to enhance the family functioning of the caregivers of stroke survivors. Guided by a standardized protocol, this family-oriented two-tier intervention protocol was found to be feasible among Chinese families.

Trial Registration

ClinicalTrials.gov NCT03034330; https://ichgcp.net/clinical-trials-registry/NCT03034330

International Registered Report Identifier (IRRID)

RR1-10.2196/16703
On the hereditary character of certain spectral properties and some applications
Authors: Carpintero Carlos Rafael , Rosas Rodriguez Ennis Rafael , García Mojica Orlando J. , José Eduardo Sanabria José Eduardo , Malaver Andrés
Published: April 2021

In this paper we study the behavior of certain spectral properties of an operator T on a proper closed and T-invariant subspace W ⊆ X such that Tn (X) ⊆ W, for some n ≥ 1, where T ∈ L(X) and X is an infinite-dimensional complex Banach space. We prove that for these subspaces a large number of spectral properties are transmitted from T to its restriction on W and vice-versa. As consequence of our results, we give conditions for which semiFredholm spectral properties, as well as Weyl type theorems, are equivalent for two given operators. Additionally, we give conditions under which an operator acting on a subspace can be extended on the entire space preserving the Weyl type theorems. In particular, we give some applications of these results for integral operators acting on certain functions spaces.
Discursos y prácticas en experiencias de cuidado comunitario. Una perspectiva moral entre cuidados gaseosos, líquidos y sólidos
Authors: García García Sergio , Sanz Abad Jesús , Ugena-Sancho Sofía
Published: April 2021

El presente texto presenta los resultados de una investigación antropológica centrada en el funcionamiento de distintos proyectos de cuidado comunitario (dos de vivienda cooperativa, uno de ellos senior, y otro de crianza colectiva). A través de una aproximación etnográfica, se comparan los discuros y las prácticas presentes en las distintas experiencias. Los resultados muestran la trascendencia de la individualidad como elemento común en el sentido que otorgan los participantes a los proyectos, y el empleo de significados situados entre el parentesco y la amistad a falta de referentes culturales de cuidado comunitario. En segundo lugar, la investigación revela el uso del concepto de cuidado para nombrar situaciones de muy diversa intensidad y compromiso, lo cual conduce a elaborar la categorización etic de cuidados gaseosos, líquidos y sólidos. Por último, partiendo de esa misma categorización, la investigación encuentra una modulación de las obligaciones morales de los participantes en función de la intensidad de los cuidados, mostrando así los límites de las experiencias a la hora de afrontar los cuidados materiales más sólidos.
Desigualdad persistente, pero no un techo de cristal. Sobre género y autoridad en el trabajo
Authors: Caínzos Miguel
Published: April 2021

El objetivo del artículo es estudiar las desigualdades de género en autoridad en el trabajo en España, tomando como punto de partida las aportaciones de Erik Wright. Se describe la magnitud, forma y variación temporal de esta desigualdad y se pone a prueba la hipótesis del "techo de cristal", es decir, la hipótesis de que la desventaja relativa de las mujeres es mayor en los niveles más altos de la jerarquía de autoridad que en los inferiores. Los datos proceden de la "Encuesta de Estructura, Conciencia y Biografía de Clase" (1991), la "Encuesta Sociodemográfica" del INE (1991), la "Encuesta de Calidad de Vida en el Trabajo" (1999-2004) y varias submuestras anuales de la "Encuesta de Población Activa" (2006-2013). Se concluye que, en España, hombres y mujeres tienen probabilidades desiguales de ocupar posiciones de autoridad, pero la evidencia disponible no respalda la hipótesis del "techo de cristal".
¿El triunfo final del marxismo analítico? Erik Olin Wright y la ciencia social
Authors: Noguera José Antonio
Published: April 2021

La muerte de Erik Olin Wright ha sido recibida casi unánimemente como una gran pérdida para la ciencia social y su obra ha suscitado sonoros elogios entre los sociólogos. Resulta sorprendente comparar dicha reacción con la recepción hostil que tuvo el marxismo analítico en la sociología y especialmente entre los sociólogos marxistas durante el siglo XX. En este artículo se examinará la concepción de la ciencia social que Erik Olin Wright defendió y aplicó analizando los principios metodológicos y epistemológicos que según él identificaban al marxismo analítico, corriente teórica con la que mantuvo un compromiso explícito a lo largo de toda su trayectoria. Ello llevará a diseccionar críticamente qué había de “marxista” en el marxismo analítico, así como la noción de “ciencia social emancipatoria” de Wright, mostrando que acaba sucumbiendo al dilema epistémico-normativo que ha atenazado a todas las corrientes de “sociología crítica”.
Reflexiones sobre la accesibilidad de la población extranjera a los programas nacionales de rentas mínimas: una lectura comparada
Authors: Peris-Cancio Lluis Francesc
Published: April 2021

El artículo propone un análisis sobre la accesibilidad de los extranjeros a los programas de renta mínima con la voluntad de estimular el debate sobre el impacto que la reciente introducción del Ingreso Mínimo Vital (IMV) puede tener en los ciudadanos de otras nacionalidades en España. Se realiza una comparación entre Alemania, Francia, Italia y España, con la finalidad de conocer las diferencias y similitudes en las condiciones de vida, el  riesgo de pobreza, la exclusión social y el acceso efectivo a los regímenes de renta mínima entre las poblaciones nacionales y extranjeras. En la parte conclusiva se ilustran algunos factores clave para ampliar la inclusividad de los programas observando el caso español.
Valuasi ekonomi sumber daya alam kawasan hutan lindung Siregol di Desa Sirau, Kecamatan Karangmoncol, Purbalingga
Authors: Pramestyan Ageng
Published: April 2021

This research is about the valuation of natural resources, especially the direct use value of the Glagah Arjuna (Themmeda fillosa) plant. The objective of this research is to determine the value of the natural resources of the Siregol Protected Forest area in Sirau Village, Karangmoncol District, Purbalingga Regency. The method used in this research is the Production Function Approach method and the data collection techniques use interview techniques (primary data) and literature study (secondary data). The population taken in this study were farmers of Glagah Arjuna Sirau Village, Karangmoncol District, Purbalingga Regency, by taking a sampling of 4 respondents from the total Glagah Arjuna farmers in Sirau Village, the data obtained were analyzed using descriptive qualitative. The results of the research conducted, obtained the total economic value of the ecosystem of the Siregol Protected Forest area specifically for the cultivation of Glagah Arjuna plants of Rp. 3,036,262,500.00. The potential value of natural resources obtained can be increased considering that not all of the Siregol Protected Forest area has been utilized.
Regulasi Sanitasi Makanan di Kantin Madrasah Ibtidaiyah Kota Bandar Lampung Tahun 2020
Authors: Ixroni Derius , Dwi Nuryani Dina , Angelina Febriani Christin
Published: April 2021

Sebanyak 2.897 orang mengalami Kejadian Luar Biasa (KLB) keracunan dan 1.661 orang diantaranya sakit. Penyebab KLB ditinjau dari jenis pangan siap saji pada tahun 2018 sebanyak 33,93%. Data keracunan pangan dilihat dari kabupaten/kota yaitu 150 kasus keracunan di kota Bandar Lampung. Tujuan penelitian ini untuk mengetahui Regulasi Sanitasi Makanan Di Kantin Madrasah Ibtidaiyah Kota Bandar Lampung Tahun 2020. Penelitian ini menggunakan metode diskriptif kualitatif untuk mengetahui penerapan regulasi sanitasi makanan di kantin Madrasah Ibtidaiyah kota Bandar Lampung, dilakukan di 5 Madrasah Ibtidaiyah yang ada di kota Bandar Lampung yaitu MIN 3, MIN 6, MIN 9, MI Hidayatul dan MI Ismaria. Jenis data yang digunakan ialah data primer dengan observasi dan wawancara mendalam, serta data sekunder yaitu telaah dokumen Madrasah yang berkaitan dengan regulasi sanitasi makanan. Disimpulkan bahwa Madrasah Ibtidaiyah Kota Bandar Lampung sudah menerapkan regulasi sanitasi makanan di kantin dan sebagian madrasah membuat peraturan secara tertulis serta mengimplementasikan regulasi sanitasi makanan dengan mensosialisasikan kepedagang kantin. Penanggungjawab kantin juga melakukan pemantauan untuk bahan makanan, penyimpanan bahan makanan, penyimpanan makanan yang telah dimasak serta cara penyajian makanan tersebut.

Kata Kunci : Sanitasi makanan, Implementasi Regulasi Sanitasi Makanan, Kantin
Indeks Kepuasan Masyarakat Pada Pelayanan Puskesmas Kota Jambi
Authors: Ena Sari Rumita , Astuti Siregar Sri , Guspianto Guspianto
Published: April 2021

Pelayanan publik harus memuaskan penggunanya yaitu masyarakat. Salah satu bentuk pelayanan publik dalam bidang kesehatan adalah pelayanan puskesmas. Berdasarkan hasil wawancara dengan 30 orang pasien di 5 puskesmas Kota Jambi, pasien mengeluhkan lambatnya pelayanan, petugas yang tidak ramah, waktu tunggu yang lama, kursi ruang tunggu yang sedikit, dan masih banyak masalah lain yang menyebabkan pasien kurang nyaman dan tidak puas dengan pelayanan puskesmasPenelitian ini merupakan penelitian survey dengan sampel sebanyak 2000 responden di 20 puskesmas Kota Jambi. Sampel dihitung dengan rumus survey kepuasan masyarakat sesuai dengan Permenpan RB No 44 Tahun 2017. Teknik pengambilan sampel dilakukan dengan accidental. Berdasarkan hasil penelitian, didapatkan dua puskesmas dengan indeks kepuasan masyarakat “BAIK” yaitu puskesmas simpang empat sipin dan puskesmas pakuan baru. Sebanyak 18 puskesmas dengan indeks kepuasan masyarakat “KURANG BAIK”.  Saran dalam penelitian ini agar puskesmas Kota Jambi harus lebih meningkatkan nilai pada setiap unsur secara maksimal sesuai dengan Permenpan No 14 Tahun 2017.

                Kata Kunci: Indeks, Kepuasan, Masyarakat, Puskesmas
Tinjauan Yuridis Terhadap Tugas dan Kewenangan Jaksa sebagai Penyidik dalam Perkara Tindak Pidana Korupsi
Authors: Kurnia Vani , Lasmadi Sahuri , Siregar Elizabeth
Published: April 2021

ABSTRAK
Artikel ini bertujuan untuk mengetahui dan menganalisis bagaimana tugas dan kewenangan jaksa sebagai penyidik dalam tindak pidana korupsi dan menganalisis bagaimana tugas dan kewenangan jaksa sebagai penyidik dalam Tindak Pidana Korupsi di masa yang akan datang. Metode Penelitian yang digunakan adalah yuridis normatif. Hasil dari penelitian ini adalah 1)Bahwa dari segi yuridis, jaksa memiliki wewenang dalam melakukan penyidikan tindak pidana korupsi, namun kewenangan masing-masing sub sistem dalam sistem peradilan pidana tindak pidana korupsi harus diperjelas karena sangat menentukan sekali agar kepastian hukum dan kesebandingan hukum dapat tercapai. 2)Bahwa kewenangan penyidikan tindak pidana korupsi yang dimiliki oleh jaksa saat ini berbenturan dengan sistem peradilan pidana yang berlaku di Indonesia. Jika kewenangan penyidikan oleh kejaksaan masih dipertahankan maka terkesan tidak adanya koordinasi antar lembaga penegak hukum karena hampir dalam setiap tahapan penegakan hukum tindak pidana korupsi yaitu tahap penyelidikan, penyidikan, penuntutan dan pelaksanaan putusan pengadilan atau eksekusi, dimiliki oleh lembaga kejaksaan.
ABSTRACT
This article aims to find out and analyze how the duties and powers of prosecutors as investigators in criminal acts of corruption and analyze the duties and powers of prosecutors as investigators in corruption in the future. The research method used is normative juridical. The results are 1) Whereas from a juridical perspective, the prosecutor has the authority to carry out investigations into criminal acts of corruption, however, the authority of each sub-system in the criminal justice system for corruption must be clarified because it is very decisive so that legal certainty and legal equivalence can be achieved. 2) Whereas the prosecutor's current authority to investigate criminal acts of corruption clashes with the criminal justice system in force in Indonesia. If the investigative authority is maintained by the prosecutor's office, it seems that there is no coordination between law enforcement agencies because almost every stage of law enforcement on corruption, namely the investigation, investigation, prosecution and implementation of court decisions or executions, is owned by the prosecutor's office.
Perspektif masyarakat di Kota Padang terhadap rencana kebijakan redenominasi mata uang rupiah
Authors: Zulhaisa Marshely , Karimi Syafruddin , Ridwan Endrizal
Published: April 2021

This study aims to examine the perceptions of the people in the city of Padang on the plan to redenominate the rupiah currency and see how the redenomination's impact the economy. The data used are primary by distributing questionnaires to the community according to sub-districts in Padang City, where the data are grouped based on the highest level of education attained. The data analysis method in this research is qualitative by using descriptive analysis of the frequency and descriptive analysis of cross-tabulations (crosstabulation). From the results of this study, it was found that some people did not agree with the redenomination policy because they did not understand this policy. From the results of the crosstabulation descriptive analysis, it can be seen that there is a relationship between the level of education and the perception of the impact of redenomination on the exchange rate and consumption patterns. Meanwhile, there is no relationship between education level and knowledge of redenomination, opinion on redenomination policy, and perceptions about the impact of redenomination on inflation and savings.

Keywords: Community perspective, Redenomination, Sanering, Inflation, Exchange rate
Analisis faktor-faktor yang mempengaruhi pendapatan rumah tangga miskin di Kabupaten Tanjung Jabung Barat (studi kasus di Desa Semau Kecamatan Bram Itam)
Authors: Rafii Ahmad , Yulmardi Yulmardi , Bhakti Adi
Published: April 2021

The research aims to 1). Knowing the socioeconomic characteristics of poor households 2). Knowing the effect of working hours, education, age, and land area on the income of poor households in Semau Village, Bram Itam District, Tanjung Jabung Barat Regency. The research used descriptive analysis method and quantitative analysis with multiple linear regression analysis. Based on the results of the analysis of the characteristics of poor households in Semau villages, dominated by the age of 15-64 years (61.01%), the work of farmers (53.22%), the average income is IDR 650,000 (41-9%), work 180-230 hours (61.29%), education level did not complete elementary school (43.5%), age> 50 years (53.2%), land area (64.5%). Simultaneously the outpouring of working hours, education, age, and land area have a significant effect, partially education and land area have a positive and significant effect, the number of working hours and age do not have a significant effect on the income of poor households in Semau Village, Bram Itam District, Tanjung Jabung Barat Regency.
Keywords: Socio-economic characteristics, Income, Work hours expenditure, education, Age, Land area
Analisis permintaan kredit pada Bank BPR Tanggo Rajo Kuala Tungkal
Authors: Rimawita Rimawita , Hodijah Siti , Mustika Candra
Published: April 2021

This study aims to: 1) To analyze the development of interest rates on credit, inflation, economic growth, and demand for credit in banks at BPR Tanggo Rajo. and 2) To analyze the effect of the interest rate on credit, inflation, and economic growth on the demand for bank credit in banks at BPR Tanggo Rajo. Based on the simultaneous test results, the variables of credit interest rates, inflation, and economic growth together have a significant effect on credit demand at BPR Tanggo Rajo. Whereas in the partial only variable interest rates and economic growth have a significant and negative effect on credit demand at BPR Tanggo Rajo, while the inflation variable does not have a significant and negative effect on credit demand for BPR Tanggo Rajo.
Keywords: Credit demand, Credit interest rates, Inflation, Economic growth
Analisis faktor-faktor yang mempengaruhi pendapatan pedagang kaki lima di Kota Jambi (studi kasus warung manisan Kecamatan Telanaipura)
Authors: Aulia Inderianti Ravisca , Hardiani Hardiani , Rosmeli Rosmeli
Published: April 2021

This study aims to: 1) To determine and analyze the socio-economic characteristics of street vendors at candied stalls in Telanaipura District, Jambi City. 2) knowing and analyzing the factors that influence the income of street vendors at candied stalls in Telanaipura District, Jambi City. The research analysis tool uses multiple linear regression analysis tools. Based on the results of multiple linear regression, it can be concluded that simultaneously the independent variable fixed capital, operating capital, working hours, length of business, and location have a significant effect on the dependent variable income of the candied warung merchants and partially only the operating capital and working hours variables have a significant effect on traders' income. candied stalls, while the variables of fixed capital, length of business, and location did not have a significant effect on the income of the candied stall traders. Furthermore, the R-square value is 0.923. This means that 92.3 percent of the variation in the income of the candied shop traders is explained by the variables in this study, while the remaining 7.7 percent is explained by other variables outside the research.

Keywords: Income, Fixed capital, Operating capital, Working hours, Length of business, location
Analisis pengaruh infrastruktur tingkat upah dan pertumbuhan ekonomi terhadap penanaman modal asing di Provinsi Jambi
Authors: Syaparuddin Syaparuddin , Artis Dearmi , Zamzami Mujli
Published: April 2021

The objectives of this study are: (1) To analyze how the development of infrastructure, wage rates, economic growth, and foreign investment in Jambi Province in 2000-2017. (2) Analyzing how the influence of infrastructure, wage rates, and economic growth on foreign investment in Jambi Province in 2000-2017. The method used in this research is quantitative descriptive analysis and multiple linear regression with the ordinary least square (OLS) method. F Test results show that simultaneously the infrastructure variables, wage rates, and economic growth have a significant effect on foreign investment in Jambi Province. The t-test shows partially infrastructure and wage levels have a positive and significant effect on foreign investment in Jambi Province. Meanwhile, economic growth has no significant effect on foreign investment in Jambi Province.

Keywords: Infrastructure, Wage rate, Economic growth, Foreign investment
Penerapan akuntansi SAK EMKM dalam penyusunan laporan keuangan studi kasus pada usaha sayangan di Desa Kebakalan
Authors: Fitriyyah Rif’atul , As’adi As’adi , Sularsih Hermi
Published: April 2021

The purpose of this research is to know whether the financial statements of the business of love are in accordance with the SAK EMKM and to find out the obstacles in making reports. Data collection methods that will be carried out by researchers are: (1) Interview (2) Observation (3). Documentation. The results of interviews, observations and documentation carried out on the love business show that the business owner keeps records and makes bookkeeping reports. However, the owner admits that keeping records and compiling simple accounting reports is in accordance with the needs of the business owner. Recording and preparation of bookkeeping reports are still not in accordance with the science of accounting, because the recording does not show the stages like those in the accounting cycle and recording can only be understood by the business owner himself. The records carried out by Usaha Sayangan also do not show accurate results, because they do not carry out routine records and finances are still mixed with personal finances.

Keywords: Accounting implementation SAK EMKM, Financial statement preparation
Analisis modal kerja untuk meningkatkan profitabilitas
Authors: Ambarwati Yuniar , Sularsih Hermi , Maralelo Siregar Datuk
Published: April 2021

The research objective was to determine the working capital management of UD. Nila Kencana and to see the management of working capital in increasing the profitability of UD. Nila Kencana. In this study, the type of research chosen is descriptive research with a quantitative approach or field research, which is a research method that is inductive, objective, and scientific in which the data obtained is in the form of numbers or statements that are scored, and analyzed by analysis. statistics. The results showed that the level of networking capital increased in 2017-2018. Management of current and current assets in an effective way using the right policies will provide results in the form of profits that are planned for working capital management in 2016-2017 which is effective with working capital management balanced with an increase in company profits. Meanwhile, in 2017-2018 the effectiveness of increasing working capital was not matched by an increase in company profits. Meanwhile, in 2017-2018 the effectiveness of increasing working capital was not matched by an increase in company profits. This is due to an increase in the cost of goods manufactured which indicates an increase in the level of purchases in 2018 and has an impact on the cost of goods sold.

Keywords: Working capital, Profitability, Financial ratio
Rituximab-Induced Acute Lympholysis and Pancytopenia After COVID-19 Vaccination
Authors: Lin Yuankai , Leung Victoria
Published: April 2021

Current guidelines do not adequately acknowledge the potential acute
consequences in patients receiving both rituximab and COVID-19
vaccination. We report a case of rituximab-induced lympholysis and
pancytopenia in a patient who received Moderna COVID-19 vaccine ten days
before rituximab infusion. These observations highlight the urgent need
to update current guideline.
Optimizing rates and access to Caesarean sections in India: A cost-effectiveness analysis
Authors: Roa Lina , Caddell Luke , Pyda Jordan , Choksi Namit , Devi Shylaja , Boatin Adeline , Shrime Mark
Published: April 2021

Objective: Assessment of the cost-effectiveness of strategies to scale
up cesarean sections (CS) Design: Cost-effectiveness analysis to
evaluate three different strategies to scale up CS Setting: Rural and
urban areas of India with varying rates of CS and access to
comprehensive emergency obstetric care (CEmOC) Population: Women of
reproductive age in India Methods: Three strategies with different
access to CEmOC and CS rates were evaluated: (A) India’s national
average (50.2% access, 17.2% CS rate), (B) rural areas (47.2% access,
12.8% CS rate) and (C) urban areas (55.7% access, 28.2% CS rate). We
performed a first-order Monte Carlo simulation using a 1-year cycle time
and 35-year time horizon. All inputs were derived from literature. A
societal perspective was utilized with a willingness-to-pay threshold of
$1,940. Main outcome measures: Costs and quality-adjusted life years
were used to calculate the incremental cost-effectiveness ratio (ICER).
Maternal and neonatal outcomes were calculated. Results: Strategy C with
the highest access to CEmOC despite the highest CS rate was
cost-effective, with an ICER of 354.90. Two-way sensitivity analysis
demonstrated this was driven by increased access to CEmOC. The highest
CS rate strategy had the highest number of previa, accreta and ICU
admissions. The strategy with the lowest access to CEmOC had the highest
number of fistulae, uterine rupture, and stillbirths. Conclusions:
Morbidity and mortality result from lack of access to CEmOC and overuse
of CS. While interventions are needed to address both, increasing access
to surgical obstetric care drives cost-effectiveness and is paramount to
optimize outcomes.
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis
Authors: Picard Alexandre , Metref Salima , Tarussio David , Dolci Wanda , Berney Xavier , Croizier Sophie , Labouebe Gwenaël , Thorens Bernard
Published: April 2021

The counterregulatory response to hypoglycemia is an essential survival function. It is controlled by an integrated network of glucose-responsive neurons, which trigger endogenous glucose production to restore normoglycemia. The complexity of this glucoregulatory network is, however, only partly characterized. In a genetic screen of a panel of recombinant inbred mice we previously identified Fgf15, expressed in neurons of the dorsomedial hypothalamus (DMH), as a negative regulator of glucagon secretion. Here, we report on the generation of Fgf15CretdTomato mice and their use to further characterize these neurons. We show that they were glutamatergic and comprised glucose-inhibited and glucose-excited neurons. When activated by chemogenetics, Fgf15 neurons prevented the increase in vagal nerve firing and the secretion of glucagon normally triggered by insulin-induced hypoglycemia. On the other hand, they increased the activity of the sympathetic nerve in the basal state and prevented its silencing by glucose overload. Higher sympathetic tone increased hepatic Creb1 phosphorylation, Pck1 mRNA expression, and hepatic glucose production leading to glucose intolerance. Thus, Fgf15 neurons of the DMH participate in the counterregulatory response to hypoglycemia by a direct adrenergic stimulation of hepatic glucose production while suppressing vagally induced glucagon secretion. This study provides new insights into the complex neuronal network that prevents the development of hypoglycemia.
Genetic Risk Factors for CVD in Type 1 Diabetes: The DCCT/EDIC Study
Authors: Bebu Ionut , Keshavarzi Sareh , Gao Xiaoyu , Braffett Barbara H. , Canty Angelo J. , Herman William H. , Orchard Trevor J. , Dagogo-Jack Samuel , Nathan David M. , Lachin John M. , Paterson Andrew D.
Published: April 2021

OBJECTIVE

The role of genetic factors in the risk of cardiovascular disease (CVD) for patients with type 1 diabetes (T1D) remains unknown. We therefore examined whether previously identified genetic factors for coronary artery disease (CAD) are associated with the risk of CVD above and beyond established demographic and clinical factors in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study.

RESEARCH DESIGN AND METHODS

Polygenic risk scores (PRS) and individual genetic variants identified in previous studies were obtained from genome-wide genotyping performed in 1,371 DCCT/EDIC participants. Two composite CVD outcomes were considered: major adverse cardiovascular events (MACE) (CVD death or nonfatal myocardial infarction [MI] or stroke) and any CVD (MACE plus confirmed angina, silent MI, revascularization, or congestive heart failure). Cox proportional hazards models assessed the association between the genetic factors and the risk of CVD with adjustment for other factors (including age, lipids, blood pressure, and glycemia).

RESULTS

CAD PRS was strongly associated with the subsequent risk of any CVD (42% and 38% higher risk per 1-SD increase in unadjusted and fully adjusted models, respectively; P < 0.0001) and with the risk of MACE (50% and 40% higher risk per 1-SD increase in unadjusted and fully adjusted models, respectively; P < 0.0001). Several individual single nucleotide polymorphisms were also nominally associated with the risk of any CVD and MACE.

CONCLUSIONS

Genetic factors are associated with the risk of subsequent CVD in individuals with T1D above and beyond the effect of established risk factors such as age, lipids, blood pressure, and glycemia.
Sensory, Nutritional and Microbiological Characteristics of Fermented Finger Millet Beverage (Kunun-Tamba) Treated with Various Preservatives during Refrigerated Storage
Authors: OO Agarry
Published: April 2021

Six types of ‘kunun-tamba’ produced in this study using finger millet ( Eleucine coracana L) were treated with (sodium benzoate, lime and lemon juice extracts singly or in combination) or without preservatives and evaluated for its microbiological (lactic acid bacteria-LAB), chemical and sensory quality characteristics throughout four weeks of refrigerated (4 o C) storage. The molecular characteristics of the seven (7) LABs isolated showed that Lactobacillus plantarum, Lactococcus lactis, Leuconostoc masenteroides, L paeudo-mesenteroides and two (2) unidentified LABs were the predominant. The ‘kunun-tamba’ treated with 5ml lime+lemon showed a low LAB count (Log 10 0.86-1.25cfu/ml), pH (3.90-4.08) and sensory attributes (taste: 6.7-6.9, appearance: 6.6-6.9, aroma: 6.1-6.8) evaluated throughout the study period (4 weeks) which differed (p<0.05) from those of the other products produced in this study. The results of this study shows that the use of the combinations of lime and lemon (5ml) natural preservatives gave a better shelf stable product than an artificial preservative (sodium benzoate) and therefore could be a suitable alternative meeting consumers aspiration for replacement of artificial preservatives with natural ones.
ALGUNOS COCCINELLIDOS (COLEÓPTERA: COCCINELLIDAE) PREDADORES DE IMPORTANCIA ECONÓMICA EN EL DEPARTAMENTO DEL CUSCO, PERÚ
Authors: Bustamante-Navarrete Abdhiel Arnaldo
Published: April 2021

El examen de cerca de 2500 especímenes de la familia Coccinellidae, presentes en la Colección Entomológica de la Universidad Nacional San Antonio Abad del Cusco, Perú, permitió determinar la presencia de 16 especies de conocidos hábitos predadores de importancia económica, provenientes de 74 localidades en 40 distritos de las 13 provincias del departamento del Cusco. Las 16 especies se hallan distribuidas en 10 géneros y 7 tribus, todas ellas dentro de la sub familia Coccinellinae Mulsant: Eriopis peruviana Hofmann, 1970, Eriopis andina Hofmann, 1970, Eriopis minima Hofmann, 1970, Paraneda pallidula guticollis (Mulsant, 1850), Cycloneda vandenbergae González, Bustamante & Oróz, 2008, Cycloneda sanguinea (Linnaeus, 1763), Cycloneda dieguezi González, 2018, Cycloneda arcula (Erichson, 1847), Hippodamia convergens (Guerin-Meneville, 1842), Hippodamia variegata (Goeze, 1777), Azya scutata Mulsant, 1850, Scymnus (Pullus) rubicundus Erichson, 1847, Hyperaspis festiva (Mulsant, 1850), Rodolia cardinalis (Mulsant, 1850), Parastethorus histrio (Chazeau & Fursch, 1974), Curinus coeruleus Mulsant, 1850. Se indica una diagnosis para cada especie, su distribución en el departamento e imágenes de su habitus y aparato genital.

 
NECESIDAD ANALÍTICA ANTE LA PROBABLE OCURRENCIA POR ANTIBIÓTICOS EN LA LAGUNA DE LA HUACACHINA - ICA, PERÚ
Authors: Argota-Pérez George , Pari-Olarte Josefa B. , Belli-Carhuayo Félix R.
Published: April 2021

La presencia de los antibióticos constituye una preocupación ambiental. El propósito de la nota al editor fue indicar la necesidad analítica ante la probable ocurrencia por antibióticos en la laguna de la Huacachina-Ica, Perú. Desde el punto de vista físico sobre la columna de agua se aprecia una inadecuada calidad y se desconoce, si el contenido químico de su fango, aún conserva sus características medicinales. Ante la posible ocurrencia de antibióticos en las aguas como del sedimento se comunica la trascendencia hacia una nueva configuración analítica de su condición ambiental.
FERTILIZACIÓN COMO ESTRATEGIA DE MITIGACIÓN Y ADAPTACIÓN DEL CULTIVO DE MAIZ PARA FUTUROS CAMBIOS CLIMÁTICOS
Authors: Jaime-Huaman Emerson
Published: April 2021

Se realizó una ecuación de modelación para cambios climáticos del año 2080 y 2099 bajo el cuarto escenario climático planteado por la IPCC (Grupo Intergubernamental de Expertos sobre el Cambio Climático) donde se asume un nivel muy alto de emisiones de gases de efecto invernadero (RCP “trayectoria de concentración representativa” 8,5); para predecir el rendimiento de la producción de maíz con baja o nula fertilización y alta fertilización como técnica de adaptación y mitigación de los efectos adversos del cambio climático. El porcentaje de reducción del rendimiento de maíz para el año 2080 con baja o ninguna aplicación de fertilizante es de 30 a 55%, y con alta aplicación de fertilizantes es de 10 a 20%. El cambio climático causaría impactos negativos en la producción agrícola futura y la seguridad alimentaria. La fertilización es uno de las estrategias de mitigación y adaptación del cultivo de maíz frente cambio climático.
ALGORITMO DE RECONSTRUCCIÓN DE EVENTOS PARA LA RECONSTRUCCIÓN 3D DE CORONAVIRUS (COVID-19), SEGÚN EL ESTUDIO DE SU REACCIÓN A TRAVÉS DEL TRATAMIENTO DE ANÁLISIS ANTIVIRAL
Authors: Calderón Ch J. Alan , Tafur Sotelo Julio , Barriga Gamarra Benjamín , Guevara Guevara Julio , Lozano Jauregui John , Lengua Arteaga Juan , Solano Gonzalo
Published: April 2021

Esta investigación explica las aplicaciones de reconstrucción tridimensional (3D) para las imágenes de las familias COVID-19, según la búsqueda de la correlación entre el modelo matemático "evento por evento" con efecto antiviral sobre el virus, además, el modelo matemático obtenido de la reconstrucción 3D está correlacionado con "Un modelado matemático general para las respuestas inmunitarias". Por lo tanto, el algoritmo diseñado, proporciona apoyo a los médicos a través de un análisis gráfico y predicciones con respecto a "¿Qué sucede con el virus antes de aplicar una acción como los medicamentos contra la malaria?". Muchos países están tratando de encontrar la vacuna contra COVID 19; sin embargo, muchos países sólo tienen estrategias estadísticas dadas por las restricciones de desplazamiento de la población, lo cual no es suficiente para evitar la rápida  transmisión del virus. Por lo tanto, en esta investigación se propone un análisis matemático para tratar el virus mediante un modelo predictivo basado en la reconstrucción de imágenes 3D del COVID 19, correlacionada con aplicaciones de análisis antiviral. Como consecuencia del modelo diseñado, el médico puede predecir las respuestas de las células dañadas por el virus después de aplicar antivirales o plasma sobre ellas. El algoritmo proporcionado se elabora para ser un soporte para el tratamiento del COVID 19.
GINGIVOESTOMATITIS ESTREPTOCÓCICA EN TIEMPO DE COVID-19
Authors: Llerena-Noda Viviana Yanin , Toledo-Pimentel Bárbara Francisca , Fimia-Duarte Rigoberto , Aguilera-Calzadilla Yaumara , Carmona-Escanaverino Milagros
Published: April 2021

El considerar otros patógenos en síndromes febriles durante la pandemia de la COVID-19, es una necesidad en la atención primaria de salud y revierte mayor relevancia en el examen de la cavidad bucal. Con el objetivo de describir un caso de una paciente joven con sospecha de COVID-19, a la cual se le diagnostica una gingivoestomatitis estreptocócica se realiza este artículo. Se hace referencia a los síntomas y signos que comparten ambas entidades y a los reportes de estudios de investigación   que atribuyen al virus SARS-CoV-2 nuevas manifestaciones clínicas en la cavidad bucal.
The Validity and Reliability Study of Computerized 4-Disc Version of The Tower of London Test: Planning Skills
Authors: GÜVEN DEMİR Elif , ÖKSÜZ Yücel
Published: April 2021

Planning ability is one of the core abilities and playing an essential role in problem-solving and decision-making process. Mainly, it is critical in childhood managing school-related demands and carrying out daily activities in older ages. This study aims to develop a computerized version of the 4-disc Tower of London (TOL) test. Method: The research was conducted by three studies, including children, adults, and combined samples. The research consisted of children and adults who were 5-53 years. Nonparametric tests were used, thereby that the research data had a non-normally distributed pattern. Research results show significant relationships between age and planning ability, the number of problems solved on the first trial, and the number of problems solved within three trials. Results show that increasing planning ability and the number of problems solved on the first trial was associated with increasing age. The increasing number of problems solved within three trials was associated with decreasing age. There was no significant relationship between age and planning time. Research results show that gender has an effect on planning time in the adult group. Reliability and validity results showed that the computerized version of 4-disc TOL was a reliable and valid measure as the original version. This study was conducted by healthy participants, so there is a need for psychometric study for clinical use in Turkish literature.
Clinical analysis of video recordings of the basic motor patterns (CLAVIR) for the assessment of movement disorders in children and adolescents with acute lymphoblastic leukemia
Authors: Mitrakov N. N. , Shcherbukha A. V. , Shafran P. A. , Voronin K. A. , Laysheva O. A.
Published: April 2021

Movement disorders arising in pediatric patients with acute lymphoblastic leukemia (ALL) during treatment require a more differentiated approach to diagnosis and the choice of rehabilitation methods. The aim of this study was to investigate the conceptional structure of supine-to-stand (STS) transition patterns and to develop a method for the diagnosis of movement disorders and the assessment of the effectiveness of medical rehabilitation in children and adolescents with ALL. We carried out a prospective comparative non-randomized study. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. The study included 184 children who were assigned to three groups. Group 1 (study group) included patients with ALL treated at the Center (n = 48, the median age was 14.0 years). Group 2 (control group) included patients with various serious diseases (acute myeloid leukemia, primary immunodeficiency, CNS malignancies, bone tumors, etc.) who also underwent treatment at the Center (n = 69, the median age was 14.5 years). Group 3 (control group) included healthy children and adolescents (n = 67, the median age was 14.2 years). We analyzed the characteristics of video recordings of the supine-to-stand process in apparently healthy children (Group 3) and in the patients treated at the Center (Groups 1 and 2) and then performed comparative analysis. We managed to detect, document, and divide into phases the video-based criteria of invariant characteristics of the acyclic locomotor pattern of the STS movement (from a supine to standing position with both feet on the floor). We identified the STS movement phases and clinically significant variants of STS transition patterns which were easily detectable on the video recordings. The objectivity of the analysis of the video-based criteria of invariant characteristics of the STS movement was achieved by the registration of timing characteristics of the locomotion pattern phases on video recordings. By calculating the coefficients of variation for observations from different angles and inter-researcher variability, we detected the most representative phases of the STS movement pattern on video recordings. A quantitative analysis of the STS test performance revealed significant differences between healthy controls and children with oncological diseases. The clinical analysis of video recordings of the basic motor patterns (CLAVIR) contributes a substantial amount of objective data to the clinical assessment of the diagnostic supine-to-stand test results in children and adolescents treated for ALL.
Thiopurine-induced myelotoxicity in patients with acute leukemia and benefits of preemptive pharmacogenetic testing prior to 6-mercaptopurine prescription
Authors: Ignatova A. K. , Kalinina I. I. , Evseev D. A. , Antonova K. S. , Novichkova G. A. , Maschan A. A.
Published: April 2021

Mercaptopurine (МР) is a key element of the maintenance therapy of acute leukemias. Different amounts of active and toxic metabolites can be synthesized in patients who are receiving the same doses of the drug due to pharmacokinetic differences. This contributes to the unequal drug tolerability and the need of dose adjustment. For a long time, the only tool for adjusting 6-MP dose was the level of leukocytes and granulocytes in the peripheral blood. With the understanding of genetic factors affecting the metabolism of 6-MP and development of next-generation sequencing technology, clinical guidelines for thiopurine dosing based on a pharmacogenetic approach have been emerged. In this article, we report two patients belonging to a small ethnic group in Russia with abnormal 6-MP toleration and substantiate the advantages of a personalized, pharmacogeneticallybased approach to 6-MP administration. The patient's parents agreed to use the information, including the child's photo, in scientific research and publications.
SINERGI HALODOC DALAM MUTU PELAYANAN RUMAH SAKIT DI MASA PANDEMI COVID 19
Authors: Putra Putu Aditya , Suryanata I Gusti Ngurah Putra
Published: April 2021

One of the developments in information system technology in the health sector via the internet is E-health. The Medical Teleconsultation solution offered is very helpful for the Indonesian health system in screening patients with a risk of Covid 19. Halodoc is the number 1 health application in Indonesia. The purpose of this study was to determine the Halodoc synergy in the quality of hospital services on patient satisfaction, trust, and loyalty. This research was conducted in a type c hospital in collaboration with Halodoc in Denpasar, namely Surya Husada Hospital and Bali Royal Hospital. Taken a sample of 50 respondents at each hospital. Data collection techniques using a questionnaire. This study uses data analysis methods using Smart PLS software. The results of this study were Halodoc Medical teleconsultation proved to have a positive and significant effect on patient satisfaction, patient confidence and patient loyalty. The quality of hospital services is proven to have a positive and significant effect on patient satisfaction and patient confidence. Halodoc Medical Teleconsultation proved to have a positive and significant effect on the quality of hospital services. Related to the research results, it was found that some people still trust their health fully by consulting directly with medical personnel at the hospital. This research will become an illustration to see the development of medical teleconsultation in Indonesia. As well as indirectly seeing to what extent the role of Halodoc Medical Telecosultation is able to provide optimal health services in the midst of the Covid 19 pandemic.
DETERMINAN PENGANGGURAN ANTAR KABUPATEN/KOTA DI JAWA BARAT
Authors: Kharisma Bayu , Wardhana Adhitya , Lathifah Syafira Nur
Published: April 2021

Penelitian ini bertujuan untuk menganalisa determinan pengangguran antar Kabupaten/Kota di Jawa Barat selama periode tahun 2011-2017. Metode penelitian yang digunakan adalah regresi panel data melalui model fixed effect. Hasil penelitian ini menunjukkan bahwa rata lama sekolah dan output ekonomi berhubungan negatif, sedangkan kemiskinan dan populasi memiliki hubungan yang positif terhadap pengangguran. Aspek pendidikan memiliki pengaruh dalam menurunkan pengangguran. Oleh sebab itu, perlunya peningkatan target wajib belajar sembilan tahun sebagai upaya peningkatan kualitas SDM, terutama bagi daerah yang belum mencapai target. Selanjutnya, kebijakan percepatan ekonomi dengan meningkatkan output perekonomiannya dan menjaga tingkat populasi agar terjadi keseimbangan di lapangan kerja dan angka pengangguran agar tidak terus meningkat
28. The Nose Knows: A Sensual Analysis of Paradise Lost and His Dark Materials
Authors: Zimmerman Sam
Published: April 2021

Both John Milton’s Paradise Lost and Philip Pullman’s retelling of the story, His Dark Materials, use scent imagery in descriptions of morally significant characters. But what is the significance of the consistent scent imagery? Hans J. Rindisbacher’s theory in The Smell of Books: A Cultural-Historical Study of Olfactory Perception in Literature (1992) states that scent imagery, in literature pertaining to Christian symbolism, indicates a dichotomy of morality. This theory is modified to illustrate that scent is used to signify a character’s condition of knowledge. The presence of good scent in Paradise Lost indicates that a character possesses pure knowledge of good and evil, the presence of bad scent indicates a character’s corrupt condition of knowledge of good and evil. Alternatively, the presence of good scent in His Dark Materials signifies that a character possesses pure self-knowledge, whereas the presence of bad scent indicates the corruption of a character’s self-knowledge. Furthermore, the attribution of neutral scent or lack of scent imagery to morally significant characters, such as Satan and Mrs. Coulter, signifies the morally ambiguous actions which make these characters difficult to define as virtuous or evil. The analysis of the scent imagery in Paradise Lost and His Dark Materials demonstrates the significance of scent theory in the research and analysis of literature, as a possible method of evaluating a character’s moral status.