bluuebunny/crossref_metadata_2025 huggingface dataset:
An n-dimensional pseudo-differential operator involving linear canonical transform and some applications in quantum mechanics
Authors: Pradhan Tusharakanta , Kumar Manish
Published: March 2024

In this work, an n-dimensional pseudo-differential operator involving the
n-dimensional linear canonical transform associated with the symbol ?(x1,..., xn; y1,..., yn) ? C?(Rn ? Rn) is defined. We have introduced
various properties of the n-dimensional pseudo-differential operator on the
Schwartz space using linear canonical transform. It has been shown that the
product of two n-dimensional pseudodifferential operators is an
n-dimensional pseudo-differential operator. Further, we have investigated
formal adjoint operators with a symbol ? ? Sm using the n-dimensional linear
canonical transform, and the Lp(Rn) boundedness property of the
n-dimensional pseudo-differential operator is provided. Furthermore, some
applications of the n-dimensional linear canonical transform are given to
solve generalized partial differential equations and their particular cases
that reduce to well-known n-dimensional time-dependent
Schr?dinger-type-I/Schr?dinger-type-II/Schr?dinger equations in quantum
mechanics for one particle with a constant potential.
Well-posedness and energy decay for full von Kármán system of dynamic theromelasticity damped with distributed delay and past history terms
Authors: Douib Madani , Zitouni Salah , Djebabla Abdelhak
Published: March 2024

In this paper, we study the well-posedness and the asymptotic behavior of a
one-dimensional von K?rm?n beam is coupled to a thermal effect and
frictional damping with distributed delay and past history. We first give
the well-posedness of the system by using the semigroup theory. Then, we
establish a decay result by introducing a suitable Lyapunov functionals.
İmalat Sektöründe CMM Kullanımının ve Uygulamalarının Verimlilik ve Kaliteye Etkisi
Authors: İmamoğlu Mustafa , Poyrazoğlu Oğuz , Gürkan Duygu
Published: March 2024

İmalat sektöründe CMM (Koordinat Ölçme Makinesi), işletmelerde ürünlerin kalitesinin saptanmasında, boyutsal doğruluk ve geometrik tolerans sınırlarının belirlenmesinde yaygın olarak kullanılmaktadır. İşletmelerde CMM kullanımı, verimlilik ve kalite düzeyinin artışına önemli ölçüde katkı sağlamaktadır. Günümüzde gelişen teknoloji ile CMMlerin ölçüm hassasiyetleri artmış; daha kaliteli ölçümler yapılır hale gelmiştir. Koordinat Ölçüm Makineleri, üretimden çıkan parçalar üzerinde mikron mertebesinde ölçüm yapabilmektedir. Çeşitli imalat yöntemleri ile işlenen parçaların CMM ile ölçümünde, elektronik hassas prob denilen ölçüm uçları kullanılmaktadır. Prob ile, belirlenen noktalardan malzemeye temas edilerek ölçüm yapılmaktadır. Temas edilen noktaların ölçüm sinyalleri bilgisayara iletilmektedir. İstenilen diklik, paralellik, dairesellik gibi geometrik toleransların belirtilen ölçü ve standartlara uygunluğu raporlanabilmektedir. Böylece üretilen ölçüm sapmaları ve parçanın şekil ve geometrik bozuklukları tespit edilmekte, üretimde verimlilik ve kalite artışı sağlanmaktadır. Bu çalışmada, koordinat ölçüm makinelerinin kalite ve verimlilik açısından işletmelere katkıları ve belirlenen firmalar bünyesinde kullanımı anket uygulanarak incelenmiştir. İstatistiksel olarak anket sonuçları paylaşılmıştır. Sonuç itibariyle literatüre önemli bir çalışmanın eklenmesi sağlanmıştır.
Effect of energy density on quality and properties of 18Ni300 laser clad layers by laser cladding
Authors: Li Weimin , Yang Zeyu , Gao Qi , Liu Shufen
Published: March 2024

By preparing the 18Ni300 laser clad layers at different energy densities, the pores of the laser clad layers were measured and analyzed by using the image method, and the effect of energy density on the porosity was explored by combining the experimental data. The experimental results show that the cross-sectional pores of the laser clad layers are regular in shape and do not intersect with each other, and most of the pores are gathered at the top edge of the fused cladding layer. The influence of process parameters on the morphology of the laser clad layer is obvious. The study shows that the influence of process parameters on porosity is in the order of laser power, scanning speed, and powder feeding voltage; combined with the analysis of variance table and response surface diagram, the interaction between the parameters is obvious, and combined with the change, it can achieve the purpose of reducing porosity. Porosity first increases and then decreases with the increase in the energy density, and the distribution of the energy density and porosity is divided into regions, and larger porosity can be avoided by selecting the regions. The hardness of the laser clad layer can be increased by the choice of energy density. The laser clad layer with good test results was observed to contain Co, α-Fe, and Fe7Ni3 intermetallic compounds. The microstructure is transformed from fine grains at the top to columnar dendrites at the bottom.
TRAINING AND EDUCATION ON THE USE OF WOOD WASTE IN THE FURNITURE INDUSTRY GROUP IN KARANG ANYAR VILLAGE
Authors: Firdasari  , Andriani Meri , Nova Purnama Lisa  , Azwar Yusri  , M. Iqbal Haikal
Published: March 2024

Wood waste is often found in several home furniture business locations in Langsa City, including in the furniture industry in Karang Anyar Village. The problem so far is that wood waste is not processed and utilized due to a lack of knowledge in processing wood waste into a product that has economic value and wood waste will also have a negative impact on the environment. The aim of this Community Service activity is to educate and provide training to furniture business groups to utilize sawdust waste into economically valuable products such as chipboard and blockboard. The activity method begins by coordinating with partners from the Karang Anyar Village furniture industry group totaling 12 people and then preparing the materials and tools used. The stages of making chipboard and blockboard with dimensions of 40x40x10 from wood waste are then the stage of training and education for the community and monitoring the results of activities. From the results of the activity, training participants received good benefits in understanding waste and the impacts that will arise from waste with a percentage of 45% and 70% with very good grades. However, for waste processing, the training participants only got a very good understanding of 30%. The skill of making particle board from wood waste increased after training by a percentage of 55% and participants benefited from the training by 70% for an excellent score.
IMPLEMENTATION OF THE PNM PROGRAM TO BUILD A PROSPEROUS FAMILY ECONOMY (MEKAAR) IN AN EFFORT TO IMPROVE COMMUNITY ECONOMIC PROSPERITY THROUGH ACCESS TO CAPITAL FOR SMEs IN DURI KOSAMBI
Authors: Chaerunisa Movita , Wahyunengsih
Published: March 2024

One of the financing institutions in Indonesia in the form of BUMN is PT Permodalan Nasional Madani (Persero) or commonly abbreviated as PT PNM (Persero). PT PNM (Persero) was established by the Government on June 1, 1999 with the special task of empowering micro, small, medium enterprises and cooperatives (UMKMK). Increasingly growing and having carried out business transformation, in 2015 PT PNM (Persero) launched the product PNM Mekaar (Building a Prosperous Family Economy) which provides special services for underprivileged women who are ultra micro business actors, both those who want to start a business or develop a business. The method used in this study is a descriptive qualitative research method because most of the data used in this study came from interviews with research subjects in the form of sentences or narratives. The Mekaar Program or Fostering a Prosperous Family Economy is a program to help improve the welfare of Indonesian families, especially groups of underprivileged women. The approach is taken to customers or prospective customers by motivating them to want to do business by adhering to the principles of hard work, honesty, and discipline to achieve success and improve socio-economic status or welfare. The Mekaar program also emphasizes the importance of the group's role as a forum to promote harmony, kinship, and mutual cooperation. Mentoring and financing facilitation provided by Mekaar is also carried out using a group model. As a financing program, Mekaar targets women in the underprivileged category, who are required to form groups of 10-30 members. Loans are provided without collateral using the joint responsibility method, which means that if one member of the group is unable to pay the weekly installments, the payments are the responsibility of all group members.
Accidental substance-related acute toxicity deaths in older adults in 2016 and 2017: a national chart review study
Authors: VanSteelandt Amanda , Ha Jingru Helen , Burt Jacqueline , Randell Shane
Published: March 2024

Introduction

Limited research exists on substance-related acute toxicity deaths (ATDs) in older adults (≥60 years) in Canada. This study aims to examine and describe the sociodemographic characteristics, health histories and circumstances of death for accidental ATDs among older adults.

Methods

Following a retrospective descriptive analysis of all coroner and medical examiner files on accidental substance-related ATDs in older adults in Canada from 2016 to 2017, proportions and mortality rates for coroner and medical examiner data were compared with general population data on older adults from the 2016 Census. Chisquare tests were conducted for categorical variables where possible.

Results

From 2016 to 2017, there were 705 documented accidental ATDs in older adults. Multiple substances contributed to 61% of these deaths. Fentanyl, cocaine and ethanol (alcohol) were the most common substances contributing to death. Heart disease (33%), chronic pain (27%) and depression (26%) were commonly documented. Approximately 84% of older adults had contact with health care services in the year preceding their death. Only 14% were confirmed as having their deaths witnessed.

Conclusion

Findings provide insight into the demographic, contextual and medical history factors that may influence substance-related ATDs in older adults and suggest key areas for prevention.
Étude prospective des préoccupations financières, des changements de l’état de santé mentale et de l’effet modérateur du soutien social chez les adolescents canadiens pendant la pandémie de COVID-19
Authors: Goddard Jessica A. , Pagnotta Valerie F. , Duncan Markus J. , Sudiyono Matthew , Pickett William , Leatherdale Scott T. , Patte Karen A.
Published: March 2024

Introduction

La pandémie de COVID-19 a intensifié les effets des facteurs de risque associés à la santé mentale des adolescents, en particulier les préoccupations financières. Par ailleurs, on sait que le soutien social offre une protection contre les problèmes de santé mentale pendant les périodes de stress. C’est dans ce cadre que nous avons exploré l’effet des préoccupations financières sur les variations des symptômes d’anxiété et de dépression chez les adolescents canadiens avant et pendant la pandémie, pour déterminer si le soutien social apporté par la famille et les amis modérait ces variations.

Méthodologie

Nous avons analysé des données couplées sur deux ans provenant des vagues 2018-2019 (avant la pandémie) et 2020-2021 (pendant la pandémie) de l’étude COMPASS pour 12 995 élèves canadiens du secondaire. Nous avons réalisé une série de régressions linéaires multiniveaux pour explorer les principales hypothèses à l’étude.

Résultats

Les élèves ont obtenu un score moyen de 7,2 (écart-type : 5,8) pour l’anxiété (échelle GAD-7) et de 10,0 (6,5) pour la dépression (échelle CESD-10), et 16,1 % des élèves ont déclaré avoir eu des préoccupations financières pendant la pandémie. Les préoccupations financières ont constitué un facteur de prédiction important et statistiquement significatif de scores d’anxiété plus élevés (+1,7 entre ceux qui ont répondu « vrai/le plus souvent vrai » et ceux qui ont répondu « faux/le plus souvent faux ») pendant la pandémie, mais non en ce qui concerne les scores de dépression. Il existe un lien entre un faible soutien de la part de la famille et des amis et l’anxiété ainsi qu’entre un faible soutien de la part de la famille et la dépression. Aucune interaction importante n’a été observée entre le soutien social et les préoccupations financières.

Conclusion

Les préoccupations financières liées à la pandémie ont été fortement associées à l’anxiété dans notre large échantillon d’adolescents canadiens. Les initiatives cliniques et sanitaires doivent tenir compte des préoccupations financières des adolescents et de leurs liens avec l’anxiété en période de crise.
La COVID-19 chez les personnes noires au Canada : un examen de la porté
Authors: Olanlesi-Aliu Adedoyin , Kemei Janet , Alaazi Dominic , Tunde-Byass Modupe , Renzaho Andre , Sekyi-Out Ato , Mullings Delores V , Osei-Tutu Kannin , Salami Bukola
Published: March 2024

Introduction

La pandémie de COVID-19 a exacerbé les iniquités partout dans le monde. Selon les travaux de recherche menés au Canada, les populations noires ont été démesurément exposées à la COVID-19 et ont donc risqué davantage que les autres groupes ethnoraciaux d’être infectées et hospitalisées. L’examen de la portée dont fait état cet article visait à établir la nature et l’envergure des travaux de recherche récents sur la COVID‑19 chez les personnes noires au Canada.

Méthodologie

Suivant un cadre méthodologique d’examen de la portée en cinq étapes, nous avons effectué une exploration systématique de sept bases de données et en avons extrait les études portant sur les effets de la pandémie de COVID-19 sur les personnes noires au Canada publiées jusqu’en mai 2023. Des 457 articles relevés, 124 doublons et 279 publications additionnelles ont été exclus à la suite de l’analyse des titres et des résumés. Des 54 articles restants, 39 ont été exclus à la suite de l’analyse de leur contenu et 2 articles ont été ajoutés à partir des références fournies dans les articles inclus. Au total, 17 articles ont donc fait l’objet de notre examen de la portée.

Résultats

Les taux d’infection par le virus de la COVID-19 ont été plus élevés et les taux de dépistage et de vaccination plus faibles au sein de la population canadienne noire que dans les autres groupes de population, en raison d’expériences antérieures à la COVID-19 en matière de racisme institutionnel et structurel, d’iniquités en santé et d’une méfiance à l’égard des professionnels de la santé, qui ont accentué les problèmes d’accès aux soins. La désinformation à propos de la COVID-19 a aussi exacerbé les problèmes de santé mentale au sein de la population noire du Canada.

Conclusion

Selon nos constatations, il serait nécessaire de corriger les iniquités sociales que vit la population canadienne noire, en particulier celles liées aux inégalités d’accès à l’emploi et aux soins de santé. La collecte de données raciales en ce qui concerne la COVID-19 pourrait contribuer à la formulation de politiques de lutte contre la discrimination raciale en matière d’accès aux soins de santé, de logement de qualité et d’emploi ainsi qu’en matière de correction des iniquités et d’amélioration de la santé et du bienêtre des personnes noires au Canada.
Slow journalism para explicar la crisis climática: el caso de Historias del tiempo
Authors: Fonseca Xavier , Míguez-Macho Gonzalo , Cortés-Vázquez José Antonio , Insua-Costa Damián
Published: March 2024

El cambio climático representa una amenaza existencial para la humanidad. Los fenómenos meteorológicos extremos son más recurrentes y causan un impacto mayor sobre las sociedades humanas. Sin embargo, una gran parte de la población no acaba de asimilar la verdadera dimensión de esta crisis porque carece de conocimientos suficientes para entender la naturaleza del problema. Si la comprensión resulta tan limitada se debe a la propia complejidad de la cuestión ambiental, aunque también a la prensa, que ha abordado la cobertura sobre este asunto a lo largo de los años centrándose en aspectos políticos, pero muy poco en mejorar la cultura climática. En este artículo presentamos un caso de estudio sobre un formato de comunicación científica que se llama Historias del tiempo y discutiremos sobre cómo aplica un “slow journalism” para abordar este desafío. Se analizarán las características del modelo que publica La Voz de Galicia y se ofrecerá un análisis cualitativo y cuantitativo sobre su estrategia, midiendo la influencia en términos de difusión de conceptos físicos en el ámbito nacional e internacional. Los resultados de la investigación sugieren que el tipo de periodismo que aquí se propone resulta útil para desactivar las barreras cognitivas asociadas a la crisis climática y ayuda a tener un conocimiento científico más completo mientras se combaten otros retos actuales como la evasión de noticias y la desinformación.
The Natural Rate of Interest in the Euro Area: Evidence from Inflation-Indexed Bonds
Authors:   Federal Reserve Bank of San Francisco, Christensen Jens H.E. , Mouabbi Sarah ,   Banque de France
Published: March 2024

The so-called equilibrium or natural rate of interest, widely known as r*t, is a key variable used to judge the stance of monetary policy. We offer a novel euro-area estimate based on a dynamic term structure model estimated directly on the prices of bonds with cash flows indexed to the euro-area harmonized index of consumer prices with adjustments for bond-specific risk and real term premia. Despite a recent increase, our estimate indicates that the natural rate in the euro area has fallen about 2 percentage points on net since 2002 and remains negative at the end of our sample. We also devise a related measure of the stance of monetary policy, which suggests that monetary policy in the euro area was not accommodative at the height of the COVID-19 pandemic.
Lo scavo nell’angolo SudEst del tempio D (saggio 8)
Authors: Amara Giulio , Rignanese Giuseppe , Vannucci Giulia
Published: March 2024

Il contributo presenta i risultati del saggio di scavo (8) eseguito, durante la campagna di  indagini del 2022, presso l’angolo sud orientale del Tempio D di Agrigento, tra lo stereobate  e la gradinata antistante all’edificio sacro. Per la prima volta su base archeologica, lo scavo ha fatto luce sulla cronologia, sulle fasi edilizie e sulla tecnica costruttiva delle fondazioni.  L’analisi dei reperti ceramici rinvenuti nei livelli di riempimento delle fondazioni fornisce un termine cronologico per l’inizio dei lavori dell’edificio sacro. L’analisi delle statuette  fittili votive, portate alla luce nel medesimo contesto, consente di comprendere alcuni inediti  aspetti delle attività rituali, praticate nell’area nelle fasi antecedenti alla sua  monumentalizzazione, e di individuare le caratteristiche della divinità titolare del culto.
Lo scavo dell’ephebikon (2021-23): una sintesi, in prospettiva
Authors: Ampolo Carmine , Parra Maria Cecilia
Published: March 2024

Viene presentata una sintesi dei risultati delle più recenti indagini lungo il lato meridionale dell'agorà di Segesta, avviando così una lettura complessiva della stessa. Le indagini hanno colmato una lacuna nella conoscenza di questo settore, permettendo di rivedere ipotesi precedenti. Particolare attenzione è rivolta all'ephebikon, il monumento così definito in una dedica iscritta su una base di statua conservata in situ al suo interno. Questo termine ha aperto molte nuove prospettive di ricerca sul rapporto agorà/ginnasio e su molti altri aspetti storici e archeologici. L'edificio è ora leggibile nella sua intera articolazione architettonica, sia planimetrica che volumetrica; così come nel suo rapporto con la stoa meridionale della piazza. L'iscrizione sul basamento attesta l'importanza dell'autorappresentazione familiare e personale delle élites cittadine.
Beyond ethics: How perceived organizational support amplifies the impact of ethical HRM on employee commitment and performance
Authors: Radjab Enny , Tjambolang Tjare A. , Tang Muhammad , Meiniza Yayu , Amiruddin Amiruddin , Mandasari Nur Fitriayu , Sabbar Sabbar Dahham
Published: March 2024

This study explores the dynamic relationship between ethical human resources management (HRM) strategies, the level of commitment an employee feels towards their organization, and their job performance, paying particular attention to how employees’ perceptions of the support they receive from their organization can influence these interactions, especially during challenging times. Drawing on a sample of full-time non-executive Indonesian employees, the research employs descriptive statistics for initial data analysis, followed by structural equation modeling (SEM) to test the proposed hypotheses rigorously. The investigation reveals a positive relationship between ethical HRM and employee performance (EP) and organizational commitment (OC). Additionally, OC emerges as a pivotal mediator in the ethical HRM-EP link. Notably, employees’ organizational support perception (EOSP), often assumed to enhance positive organizational outcomes, displays a surprising negative moderating effect when combined with OC, suggesting a more intricate relationship than traditionally posited. These findings enhance our comprehension of how ethical HRM practices function in times of crisis, questioning conventional beliefs regarding the influence of organizational support. The study’s methodological approach, combining descriptive and advanced statistical analyses, provides a robust framework for understanding these complex relationships. This research holds significant implications for HRM practices, particularly in crisis response and management, indicating a need for nuanced support strategies that reflect the complexity of employee-organization dynamics.
Analysis of cold island effect in city parks from the perspectives of maximum and cumulative values – a case study of Xi'an City
Authors: Zhang Yao , Wang Qian , Kong Yaqian , Quan Jing , Zhang Yuxin , Zhang Yongjian
Published: March 2024

The continuous process of urbanization and climate change has led to severe urban heat island (UHI) effects. Constructing parks with cooling capabilities is considered an effective measure to alleviate UHI effects. However, most studies only quantify the cooling effect from a maximum value perspective, lacking a measure of temperature diffusion in space. This study combines the perspectives of maximum value and accumulation to define a cold island index, quantifying the cooling effect of 40 urban parks in the main urban area of Xi'an city. The results show that, on average, urban parks can reduce the surrounding environment by approximately 2.3℃, with a cooling range of about 127.1ha, which is three times the park area. Different factors drive the measurement of the cooling effect using different cold island indexes, but all indexes are highly correlated with green space area. There are significant differences in the cooling effect among different types of parks, and overall, ecological parks have the best cooling effect. The directional spread of internal cold islands in parks is most related to park shape, while external spread is related to surrounding green spaces. The research results have practical value in the construction of parks with cooling effects and the sustainable development of cities in urban planning processes..
The Influence of Perceived Value, And Trust on Wom and Its Impact on Repurchase Intention
Authors: Bernarto Innocentius , Purwanto Agus , Tulung Joy Elly , Pramono Rudy
Published: March 2024

Objective: to analyze the relationship between Perceived Value to WoM, trust to WoM and Repurchase Intention of Coffee Shop.
 
Theoretical  Framework: This study uses a consumer behavior framework, especially the theory of reason action and word of mouth.
 
Method: This research uses a quantitative approach with a survey design using a sample of 165 with convenience sampling technique. The data analysis technique used is Structural equation modeling (SEM); with the Smart PLS device to test the outer model and inner model.
 
Result: Based on the results of data analysis, it shows that perceived value, trust and word of mouth have a direct effect on repurchase intention. Apart from that, Perceive value and trust have an indirect effect on repurchase intention with word of mouth as a mediation.
 
Implications: The results of this study show that to increase repeat purchases by consumers, it is necessary to increase consumer trust and perceived value to increase word of mouth
 
Originality/Value: The results of the study contribute to coffee shop efforts to increase repurchase intentions in the future by increasing consumer value and trust
CO2-empowered Spin Transition in an Interdigitated Hofmann Co-ordination Polymer
Authors: PAUL ABHIK , Kosaka Wataru , Mondal Dibya Jyoti , Kumar Bhart , Miyasaka Hitoshi , Konar Sanjit
Published: March 2024

The increased level of the anthropogenic emission of CO2 urges the development of CO2-responsive materials that can sense and memorize the system’s information and use it as an electronic output. Herein, we report the first case of a CO2-gated reversible spin-state switching in an interdigitated Hofmann-type coordination polymer [FeIIPd(CN)4L2] (1, L = methyl isonicotinate), showing a wide range of temperature (Teq) shift from ~150 K at PCO2 = 0 kPa to ~250 K at PCO2 = 100 kPa. Interestingly, the emergence of a stepped behavior below PCO2 = 10 kPa and overlapping magnetic susceptibility values with no change in the transition temperature (TH) above PCO2 = 10 kPa elucidate the selective stabilization of the LS state under the influence of the CO2 atmosphere. Based on the magnetic response and the phase transition diagram obtained under the respective PCO2, a plausible scenario of the spin-state switching can be inter-preted as 1LS (1LS + 1’LS) (1HS + 1’LS) 1’HS 1HS, where the CO2-free and CO2-encapsulated states are represent-ed as 1, and 1’, respectively. The highly selective CO2 sorption and the magnetic sensitivity based on the varied exter-nal CO2 pressure corroborate a novel and intriguing case for the development of CO2-responsive magnets henceforth.
Concise Chemoenzymatic Synthesis of 4,5-Dihydroxyisoleucine Fragment of α-Amanitin
Authors: Chao Tsung-Han , Renata Hans
Published: March 2024

The ability of α-amanitin to potently inhibit RNA polymerase II (RNAP II) has elicited further research into its use as a novel payload for antibody-drug conjugates. Despite this promise, the de novo synthesis of α-amanitin is still a major chal-lenge, as it possesses an unusual bicyclic octapeptide structure that contains several oxidized amino acids, most notably 4,5-dihydroxy-L-isoleucine. Here, we report a concise chemoenzymatic synthesis of this key amino acid residue, which features two regio- and diastereoselective enzymatic C–H oxidations on L-isoleucine.
Hemithioindigo-based histone deacetylase inhibitors induce a light-dependent anticancer effect
Authors: Josa-Culleré Laia , Aira Rodríguez Carla , Llebaria Amadeu
Published: March 2024

Photoswitchable molecules exhibit light-dependent biological activity which allow us to control the therapeutic effect of drugs with high precision. Such molecules could solve some of the limitations of anticancer drugs by providing a localised effect in the tumour. Histone deacetylase inhibitors (HDACis) constitute a promising drug class for oncology whose application is often limited by a lack of selectivity. Herein, we developed photoswitchable HDACis based on a hemithioindigo scaffold. We established synthetic routes to access them and determined the optimal conditions for isomerisation and their thermal stability. We then optimised their enzyme activity through three rounds of re-design to identify examples that are up to 6-fold more active under illumination than in the dark. We also confirmed that our best derivative reduces the viability of HeLa cells only under illumination. All in all, we disclose a series of derivatives containing an hemithioindigo moiety, which display a light-dependent effect on both HDAC inhibition and cancer cell viability.
Genetic ablation ofImmtinduces a lethal disruption of the MICOS complex
Authors: Rockfield Stephanie M , Turnis Meghan E , Rodriguez-Enriquez Ricardo , Bathina Madhavi , Ng Seng Kah , Kurtz Nathan , Becerra Mora Nathalie , Pelletier Stephane , Robinson Camenzind G , Vogel Peter , Opferman Joseph T
Published: March 2024

The mitochondrial contact site and cristae organizing system (MICOS) is important for crista junction formation and for maintaining inner mitochondrial membrane architecture. A key component of the MICOS complex is MIC60, which has been well studied in yeast and cell culture models. However, only one recent study has demonstrated the embryonic lethality of losingImmt(the gene encoding MIC60) expression. Tamoxifen-inducible ROSA-CreERT2–mediated deletion ofImmtin adult mice disrupted the MICOS complex, increased mitochondria size, altered cristae morphology, and was lethal within 12 d. Pathologically, these mice displayed defective intestinal muscle function (paralytic ileus) culminating in dehydration. We also identified bone marrow (BM) hypocellularity inImmt-deleted mice, although BM transplants from wild-type mice did not improve survival. Altogether, this inducible mouse model demonstrates the importance of MIC60 in vivo, in both hematopoietic and non-hematopoietic tissues, and provides a valuable resource for future mechanistic investigations into the MICOS complex.
Strictly Wider Class of Soft Sets via Supra Soft δ-Closure Operator
Authors: Abd El-latif Alaa M. , Alqahtani Mesfer H. , Gharib F. A.
Published: March 2024

In this work, we use the supra soft δ-closure operator to present a new notion of generalized closed sets in supra soft topological spaces (or SSTSs), named supra soft δ-generalized closed sets. We show that, this notion is more general than many of previous notions, which presented before in famous papers. We illustrate many of its essential properties in detail. Specifically, we illustrate that the new collection neither forms soft topology nor supra soft topology. Moreover, we study the behavior of the soft image and soft pre-images of supra soft δ-generalized closed sets under new types of soft mappings, named supra soft irresolute and supra soft δ-irresolute closed. In addition, we define the concept of supra soft δ-generalized open sets, as a complement of supra soft δ-generalized closed sets. Finally, the relationships with other forms of generalized open sets in SSTSs are explored, supported by concrete examples and counterexamples. Therefore, I think the development of the notions presented in this paper are sufficiently general relevance to allow for future extensions.
Polimorfismos genéticos, câncer de bexiga e exposição a agrotóxicos: uma revisão integrativa
Authors: Santana Silmara Ferreira , Freitas Paulo Pedro de , Santos Israel Faustino dos , Moura Edilson Leite de , Silva Aline Cristine Pereira e , Farias Karol Fireman de
Published: March 2024

Objetivo: realizar uma revisão integrativa da literatura sobre polimorfismos associados com o câncer de bexiga em meio à intoxicação por agrotóxicos. Método: trata-se de uma revisão integrativa, na qual a busca foi realizada utilizando os descritores polymorphisms, agrochemical, herbicide, pesticide, "bladdercancer", "bladderneoplasm", case-control, "case-controlstudy" nas bases de dados: PubMed, Web of Science, Science Direct e Periódico da Capes. Resultados: o estudo localizou 56 documentos, destes, cinquenta e um foram excluídos por não atenderem aos critérios de elegibilidade, e cinco foram incluídos. A maioria destes estudos não mostrou claramente quais polimorfismos são associados com o câncer de bexiga em meio a exposição a agrotóxicos. Conclusão: Foi possível identificar os polimorfismos AS3MT rs11191438, AS3MT rs10748835 e AS3MT rs1046778 associados com o câncer de bexiga, mas os dados foram inconclusivos para a associação à intoxicação por agrotóxicos.
Cuidados da equipe de enfermagem no manuseio e descarte da quimioterapia antineoplásica: uma revisão integrativa
Authors: Da Conceição Maria Vitoria dos Santos , Barros Joyce dos Santos , De Azarias Larissa Caina Barbosa , De Albuquerque Mylena Bomfim , Ferreira Vitória Rejane de Lira , Oliveira Keila Cristina Pereira do Nascimento
Published: March 2024

Introdução: Devido a toxicidade da quimioterapia, os profissionais durante o manuseio e descarte, devem obrigatoriamente valer-se da utilização de Equipamentos de Proteção individual. Objetivo: Identificar as estratégias recomendadas na literatura direcionada a equipe de enfermagem sobre o descarte e manuseio das excretas de pacientes em tratamento quimioterápico antineoplásico. Metodologia: estudo tipo revisão integrativa, definição da pergunta norteadora, seguida a definição dos descritores utilizados. Após essas duas etapas foram aplicados os critérios de inclusão e exclusão. Resultados: Os estudos selecionados na amostra final, totalizando 8 artigos, revelam que a grande maioria dos profissionais tem conhecimento da importância do uso contínuo dos EPIs, mas que ainda assim necessitam de educação permanente para se fazer uso dos mesmos. Conclusão: Os resultados dos estudos pesquisados foram coerentes com o que se esperava, indicaram que a educação é crucial para aumentar a prática real em trabalhos. Palavras-chaves: Antineoplásicos, Eliminação de Excretas, Equipe de enfermagem.
O paradigma Construcionista e as Metodologias Ativas na Educação em Saúde
Authors: Ribeiro José Geraldo da Cruz Gomes , Batista Nildo Alves
Published: March 2024

O presente ensaio discute os fundamentos teóricos que embasam a andragogia e as metotologias ativas utilizadas no ensino na saúde, defendendo que seus princípios fundamentais se assentam no paradigma Construcionista de aprendizagem , em contraposição aos paradigmas Instrucionista e Tecnicista. Neste sentido, apresenta as idéias de Malcolm Knowles, Dewey, Jean Piaget, Vygotsky e Carl Rogers, ressaltando o alinhamento de suas idéias no que diz respeito à concepção de aprendizagem, aos papéis dos docentes e dos discentes no processo ensino-aprendizagem, à visão do erro e à questão da avaliação. Por fim, demonstra de que maneira cada uma destas abordagens contribui para a andragogia e para as diferentes metodologias ativas utilizadas no ensino na saúde, notadamente a Problematização, a Aprendizagem Baseada em Problemas e a Espiral Construtivista.
Estudo epidemiológico da coinfecção Tuberculose-HIV no estado de Alagoas
Authors: Santos Dayane Menezes , Rodrigues Déborah do Nascimento , Cahet Yasmyny Natasha da Silva , Lobo Ana Luiza Souza de Faria , França Amanda Costa , Santos Bruna Brandão
Published: March 2024

Objetivo: realizar a análise epidemiológica da coinfecção tuberculose-HIV, no Estado de Alagoas, de 2010 a 2019. Método: trata-se de um estudo descritivo, epidemiológico, realizado por meio de levantamento na base de dados do DATASUS. A população do estudo foi composta por todos os casos confirmados de tuberculose e coinfectados por HIV notificados no período de 2010 a 2019 e residentes em Alagoas. Resultados: observa-se o registro de 12.765 casos confirmados de tuberculose; destes, 1.296 obtiveram resultado positivo para HIV, o qual apresentou tendência de crescimento ao longo dos anos, com maior registro em 2019, com 180 casos. Observou-se também uma redução gradual, ao longo dos anos, dos índices de pacientes com TB não testados para HIV. O sexo mais acometido foi o masculino, representando 95% dos casos. Conclusão: nesta perspectiva, os resultados deste estudo possibilitaram identificar os principais aspectos epidemiológicos da coinfecção em Alagoas. Essas informações servem para subsidiar ações que podem contribuir para a elaboração de estratégias de prevenção, controle, diagnóstico e tratamento oportuno dos agravos, favorecendo a redução da morbidade.Palavras-chave: Epidemiologia; Coinfecção; Tuberculose latente.
Леся Українка й родина Косачів у «справі ратування дум»: епістолярний полілог учасників
Authors: Данилюк-Терещук Тетяна , Семенюк Лариса
Published: March 2024

This article attempts to reconstruct the polylogue of the active participants and outstanding assistants of the project aimed at preserving the kobzar and lirnytskyi repertoire from Dnieper Ukraine, initiated by Kvitka’s couple with an active participation of F. Kolessa and O. Slastion. The ethnographic tour of the Galician musicologist F. Kolessa lasted from July to August of 1908. But the epistolary exchange of opinions about phonographing, the subsequent complete publication of texts and melodies of dumas, as well as description-portraits of kobzars, that are significant for studies of the kobzars’ art history (Lesya Ukrainka’s studies about Hnat Honcharenko and Opanas Slastion’s about Stepan Pasiuha), spans the entire five-year period (1908 – 1913). More than ten people and various institutions were involved in the field of this epistolary. Olena Pchilka's publications and the materials that she, as an editor-publisher, published in the "Ridnyi Krai (Native Land)" journal contributed to the popularization of the project. Unfortunately, the complete polylogue cannot be renewed because a large part of the participants’ epistolary has been lost. The recordings of the kobzar and lirnytskyi repertoire made by Lesya Ukrainka and K. Kvitka and the materials of other members of the Kosach family convince us that they perceived and interpreted Ukrainian folklore as an important feature of Ukrainian civilization, something that formed and defined national identity over the centuries.
Лексичні одиниці мікросистеми «рослини» у фольклорних текстах із Західного Полісся
Authors: Омельковець Руслана , Свірса Діана
Published: March 2024

In linguistics, lexical semantics is one of the fundamental fields of study. The article highlights the issue of folkloristics in the context of lexical semantics, which is always relevant for studies. Studying the language of folklore is essential for understanding the traditional culture of the people and preserving the values of the nation embedded in rites, beliefs, and mythological images.

Linguistic studies of the motivational productivity of lexical groups or semantic fields are closely related to texts (folklore, folk poetry, spell texts). Lexical units of “plants” microsystem in folklore texts from western Polissia are of great linguistic importance in this context.

The internal form of many plants' names can be traced quite clearly, as we can see when elucidating the motivation of such phytonomens as maivka, molodylnyk, nekhvoroshch, vinychchia, serporiznyk, durmanyk, zaiacha kapusta (rabbit cabbage). Unfortunately, we cannot always establish the motivation for a particular name of a plant, some of them are influenced by folk etymology, as in the case of aiir (derived from the Turkish name ağir).

The study of motivational characteristics of botanical vocabulary is combined with the field of extra-linguistic semantics (mythological images, magical actions, ritual practices, symbolic images), which brings motivational models into the field of culture. Phytonyms often appear in folklore texts and manifest a special symbolic meaning in their structure, such as widow's grass, hare's ears, Tatar potion, sabers, and vydiuk.

In many cases, the folk-creative basis of the motivation of plant names is found outside the folklore text, since we can only guess about the existence of such a text (for instance, the origin of the names of such plants as bozhe derevo (the God's tree), artemizida, etc.).

Depending on the functional role, the same phytonym can have different meanings, e.g. krovavnyk is equally applicable to yarrow and St. John's wort. And medicinal marigolds, yellow pitcher plants, iron sedum, Asian honeysuckle, marsh marigolds, erect foxgloves, and celandine have the popular common name zhovtets (buttercup).

The cultural, historical, and ethnographic features of the Ukrainians, their traditions, and worldview have a significant influence on the semantic features of lexical folklorisms.
VІ Міжнародна наукова конференція “Лінгвостилістика ХХІ ст.: стан і перспективи” (28-30 вересня 2023 року, м. Луцьк)
Authors: Голоюх Лариса
Published: March 2024

The article provides the information about the 6th International Scientific Conference “Linguistic Stylistics of the 21st Century: Current State and Perspective”, organized by the Department of History and Culture of the Ukrainian Language of Lesya Ukrainka Volyn National University in collaboration with the Institute of the Ukrainian Language of the National Academy of Sciences of Ukraine and the Department of Ukrainian Studies of the University of Warsaw. The article represents an overview of the plenary session and the work of nine sections, outlines the topics and content of the delivered scientific reports, focusing attention on the current problems of linguistics highlighted at the conference. The article provides a summary overview of the plenary session and the work of nine sections, outlines the topics and content of the delivered scientific reports, and focuses attention on the current problems of linguistics highlighted at the conference.
Automatic Detection of Epileptic Seizures from EEG Signals Using Artificial Intelligence Methods
Authors: Öter Ali
Published: March 2024

Epilepsy is a neurological disorder in which involuntary contractions, sensory abnormalities, and changes occur as a result of abrupt and uncontrolled discharges in the neurons in the brain, which disrupt the systems regulated by the brain. In epilepsy, abnormal electrical impulses from cells in various brain areas are noticed. The accurate interpretation of these electrical impulses is critical in the illness diagnosis. This study aims to use different machine-learning algorithms to diagnose epileptic seizures. The frequency components of EEG data were extracted using parametric approaches. This feature extraction approach was fed into machine learning classification algorithms, including Artificial Neural Network (ANN), Gradient Boosting, and Random Forest. The ANN classifier was shown to have the most significant test performance in this investigation, with roughly 97% accuracy and a 91% F1 score in recognizing epileptic episodes. The Gradient Boosting classifier, on the other hand, performed similarly to the ANN, with 96% accuracy and a 93% F1 score.
the COMPARISON OF MELINJO CHIPS MARKETING CHANNELS IN THE SPECIAL REGIONS OF YOGYAKARTA (DIY) AND CENTRAL JAVA
Authors: Sunendar Sunendar , Kusnaman Djeimy , Sukmaya Syahrul Ganda
Published: March 2024

Emping melinjo is one of the processed products from agricultural products. This food is a kind of chips made from old melinjo fruit seeds. Emping melinjo in Bantul Regency is not only marketed in the Yogyakarta area but also outside the region. In Batang emping melinjo Regency, it is not only marketed locally, but also reaches Surabaya, Jakarta and even abroad. The marketing of emping melinjo is often constrained by unstable demand, which is a lot of demand at a certain time. This unstable consumer demand for melinjo chips can be circumvented by production arrangements. However, not all melinjo chips producers are able to make production arrangements. The research method used is descriptive method, by taking all craftsmen respondents who are in Batang Regency and Bantul Regency, while taking merchant respondents by snowball. The marketing of melinjo chips in two different regions, geographical conditions and regional characteristics make two real differences. The marketing channel for emping melinjo in Bantul Regency, DIY has four channels, while in Batang Regency, Central Java, it only has three channels. The channel with the highest number of craftsmen in Bantul as many as 30 craftsmen chose channel I, while in Batang Regency the craftsmen chose channel III to sell their business melinjo chips. The highest profit received by craftsmen/producers occurs in channel I in Batang Regency
ANALYSIS OF RICE CROP PRODUCTION CHANGES DUE TO LAND USE CHANGES IN BAGIK POLAK VILLAGE, LABUAPI SUBDISTRICT WEST LOMBOK REGENCY
Authors: Siddiqirly Muhammad , Ningsi Maulina , Mukmina Mukmina , Putri Mega Utami Regina , Selvia Siska Ita
Published: March 2024

Bagik Polak Village is located in Labuapi District, West Lombok Regency. Its area is 2.50 km2 with 7 sub-villages and a population of 4,232 people and a population density of 1,693 people/km2. Geographically, Bagik Polak is located at coordinates 8037'39" S 116007'57" E. Agricultural activities such as planting rice, corn, horticulture, and livestock, are mostly carried out by the community to meet the needs of life. However, in the last 10 years, there has been a change in the function of agricultural land to non-agricultural land. An increase in population causes this, the dynamics of development and industrial development, which require space, so it has implications for changes in land use. The purpose of this study is to analyze changes in rice crop production based on land use changes in Bagik Polak Village from 2012 to 2022. The method used in this study is the evaluative descriptive method. Data processing and analysis is carried out using ArcGis 10.8, while the stages include geometric correction, image interpretation, calculating the digitized area and field observation. The data used are Google Earth Pro satellite imagery data from 2012-2022 and rice crop production data from 2012-2022. The analysis results show that changes in the use of agricultural land into settlements and housing are the most significant changes. In 2012 the area of agricultural land was 189.51 Ha with rice production of 11.867813 quintals. However, in 2022, the area of agricultural land decreased to 168.32 Ha with rice production of 11.571725 quintals. The average rate of shrinkage of rice crop production is -0.854782108. The land conversion is the main factor causing the decline in rice crop production in Bagik Polak Village. A correlation was found between changes in agricultural land use and a decrease in rice production in Bagik Polak Village, where changes in land use were directly proportional to a decrease in rice production
THE SOIL CARBON STOCK IN THE TOURISM AREA OF GILI TRAWANGAN
Authors: Astuti Eni Widia , Bakti Lalu Arifin Aria , Kusnarta IGM , Selvia Siska Ita
Published: March 2024

This study aims to determine the distribution of carbon stocks in various land uses and total carbon stocks in the tourism area of ​​Gili Trawangan. This research was conducted in the Gili Trawangan area, Physics and Soil Conservation Laboratory, and Soil Chemistry and Biology Laboratory, Faculty of Agriculture, University of Mataram, in June-October 2022. The method used in this study was a descriptive method with a survey technique. The descriptive method can start with data collection, analysis and interpretation. Carbon in the soil in this study was obtained from the results of C-organic laboratory analysis (Walcky and Black) supported by measurements of soil unit weight (BV), soil porosity and soil texture. Meanwhile, aboveground carbon stocks were obtained through direct sampling in the field by measuring tree biomass. The results showed that the total carbon stocks in various land uses have different carbon stocks. The mixed garden had the highest carbon stock of 840.27 ton.ha-1, forest land of 83.76 ton.ha-1, and shrubs of 15.76 ton.ha-1, and the lowest carbon stock was a settlement of 3.01 ton. ha-1. Overall, carbon stocks in the tourist area of ​​Gili Trawangan are 942.8 ton.ha-1.