bluuebunny/crossref_metadata_2025 huggingface dataset:
Cutaneous Leishmaniasis Outbreak Investigation in Hajjah Governorate, Yemen, in 2018: Case-Control Study (Preprint)
Authors: Nassar Abdulkareem Ali , Abdelrazzaq Mahmood Hasan , Almahaqri Ali Hamoud , Al-Amad Mohammed Abdullah , Al Serouri Abulwahed Abduljabbar , Khader Yousef Saleh
Published: January 2021

BACKGROUND

Cutaneous leishmaniasis (CL) is endemic in Yemen. About 4440 cases were reported in 2019. On July 23, 2018, a Hajjah governorate surveillance officer notified the Ministry of Public Health and Population about an increase in the number of CL cases in Bani-Oshb, Kuhlan district, Hajjah governorate. On July 24, 2018, Yemen Field Epidemiology Training Program sent a team to perform an investigation.

OBJECTIVE

We aimed to describe a CL outbreak in Hajjah governorate and determine its risk factors.

METHODS

A descriptive study and case-control study (1:1 ratio) were conducted. Cases included people who met the suspected or confirmed case definition of the World Health Organization and lived in Bani-Oshb subdistrict during the period from August 2017 to July 2018. Controls included people living for at least 1 year in Bani-Oshb without new or old skin lesions. Crude odds ratios (cORs) and adjusted odds ratios (aORs) with 95% CI were used to test the significance of associations.

RESULTS

We identified 30 CL cases. Among the 30 patients, 7 (23%) were younger than 5 years, 17 (57%) were 5 to 14 years, 17 (57%) were females, and 23 (77%) had one lesion. The attack rate was 7 per 1000 population in the age group <15 years and 1 per 1000 population in the age group ≥15 years. On bivariate analysis, the following factors were significantly associated with CL: female gender (cOR 5.2, 95% CI 1.7-16.5), malnutrition (cOR 5.2, 95% CI 1.7-16.5), not using a bed net (cOR 14.5, 95% CI 1.7-122.4), poor house lighting (cOR 6.4, 95% CI 2.1-19.7), poor house hygiene (cOR 11.2, 95% CI 3.1-40.7), poor sanitation (cOR 14.5, 95% CI 1.7-122.4), living in houses without window nets (cOR 5.2, 95% CI 1.3-21.2), plantation around the house (cOR 6.5, 95% CI 2.1-20.5), animal barn inside or close to the house (cOR 9.3, 95% CI 1.9-46.7), raising animals (cOR 8.1, 95% CI 1.6-40.7), and having animal dung in or near the house (cOR 6.8, 95% CI 1.7-27.7). The following risk factors remained significant on multivariate stepwise analysis: female gender (aOR 22.7, 95% CI 1.6-320.5), malnutrition (aOR 17.2, 95% CI 1.3-225.8), poor house hygiene (aOR 45.6, 95% CI 2.5-846.4), plantation around the house (aOR 43.8, 95% CI 1.9-1009.9), and raising animals (aOR 287.1, 95% CI 5.4-15205.6).

CONCLUSIONS

CL was endemic in Hajjah governorate, and an increase in cases was confirmed. Many individual, housing, and animal related factors were shown to contribute to CL endemicity. Implementation of control measures directed toward altering the factors favoring contact among vectors, reservoirs, and susceptible humans is strongly recommended to control future outbreaks.
Patient experience and satisfaction with telemedicine during COVID-19: a multi-institution experience (Preprint)
Authors: Rodrigues Adrian , Yu Jonathan S. , Bhambhvani Hriday , Uppstrom Tyler , Ricci William , Dines Joshua S , Hayden-Gephart Melanie
Published: January 2021

BACKGROUND

The coronavirus disease 2019 (COVID-19) heralded an unprecedented increase in telemedicine utilization.

OBJECTIVE

Assess patient satisfaction with telemedicine during COVID-19

METHODS

Telemedicine visit data were gathered from two separate institutions (Stanford Health Care (Stanford) and the Hospital for Special Surgery (HSS)). Patient satisfaction data from HSS were captured from a Press-Ganey questionnaire between April 19, 2020 and December 12, 2020, while the Stanford data was taken from a novel survey instrument that was distributed to all patients between June 22, 2020 and November 1, 2020. There were 60,550 telemedicine visits across 93 services at Stanford, each linked with a post-visit survey. At HSS, there were 66,349 total telemedicine visits with 7,348 randomly linked with a post-visit survey. The percentage of respondents who reported the highest possible likelihood to recommend score (“LTR top box percentage”) and mean overall visit scores were recorded.

RESULTS

Over 19 weeks, the LTR top box percentage at Stanford increased from 69.6% to 74.0% (p=.0002), and HSS showed no significant change across 35 weeks (p=.7100). LTR trend stability at Stanford was observed across 11 medical, four surgical, and five oncological services (p >.05). In the multivariable model, the use of a cell phone (aOR: 1.18; 95% CI: 1.12–1.23) and tablet (aOR: 1.15; 95% CI: 1.07–1.23) were associated with higher overall scores, while visits with interrupted connections (aOR: 0.49; 95% CI: 0.42–0.57) or help required to connect (aOR: 0.49; 95% CI: 0.42–0.56) predicted lower patient satisfaction.

CONCLUSIONS

We present the largest published description of patient satisfaction with telemedicine. We found high satisfaction with telemedicine encounters across multiple measures, and we identified a number of important telemedicine-specific factors that predict increased overall visit score. These include the use of cell phones or tablets, phone reminders, and connecting before the visit was scheduled to begin. Visits with poor connectivity, extended wait times, or difficulty being seen, examined, or understood by the provider were linked with reduced odds of high scores. Our results suggest that attention to connectivity and audio/visual definition will help optimize patient satisfaction with telemedicine encounters in the future.

CLINICALTRIAL

n/a
SANATIVE EFFECT OF MULTIHERBAL FORMULATION – AKSS16-LIV01 ON CCL4-INDUCED HEPATIC DYSFUNCTION IN MICE
Authors: DARBAR SOUMENDRA , SAHA SRIMOYEE , PRAMANIK KAUSIKISANKAR , CHATTOPADHYAY ATISKUMAR
Published: January 2021

Objectives: Hepatic dysfunction is a critical public health problem affecting the global population, characterized by excessive deposition of extracellular matrix components due to increased matrix production and decreased matrix degradation. The present work was aimed to evaluate hepatoprotective effect of AKSS16-LIV01 a newly developed multiherbal formulation against carbon tetrachloride (CCl4)-induced liver dysfunction in Swiss albino mice to establish it as a bench to bedside formulation catering to the various facets of hepatic malfunction.

Methods: Thirty-six Swiss adult albino Wister mice divided into six groups. Group-I control untreated animals, Group-II received AKSS16-LIV01 (400 mg/kg), Group-III received CCl4 (1 ml/kg-bw), Group-IV received AKSS16-LIV01 (200 mg/kg) after 2 weeks CCl4 induction, Group-V received AKSS16-LIV01 (400 mg/kg) after 2 weeks CCl4 induction, and Group-VI received standard drug silymarin (100 mg/kg). At the end of the experimental period, all the animals were fasted overnight and blood was collected through retro-orbital plexus for preparation of serum and was analyzed for biochemical parameters, lipid profile, and total plasma protein. Liver tissue was collected for histological study.

Results: The combined plant extract including six Indian medicinal herbs and three medicinal spices (AKSS16-LIV01) showed significant hepatoprotective effect by controlling the various essential biochemical parameters in serum. Moreover, treatment with AKSS16-LIV01 raised the level of serum total protein, normalizes the serum biochemical and lipid profiles parameters. Pre-treatment with AKSS16-LIV01 in mice also restored the alteration of various liver parameters such as aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, blood urea nitrogen, total bilirubin, and direct bilirubin on CCl4-induced liver damage. Gross liver morphology and normal histological examination of the liver also supported hepatic protection by AKSS16-LIV01.

Conclusion: Taken together, these results suggest that AKSS16-LIV01 may induce remarkable protective effects against hepatic injury induced by CCl4 treatment.
DRUG POLYMORPHISM IDENTIFICATION USING FOURIER TRANSFORM-RAMAN SPECTROSCOPY: A COMPARATIVE STUDY OF LAMIVUDINE AND FINASTERIDE DRUGS
Authors: RAO M CHANDRA SEKHARA , REDDY R CHENNA KRISHNA , SEKHAR KB CHANDRA , YV RAMI REDDY
Published: January 2021

Objectives: Maintaining the quality of the pharmaceutical drug product during its shelf life is highly desirable. The crystalline form of the drug having the great thermodynamic stability is essential for the manufacturers in pharmaceutical industry in view of their profit and also for the safety of the customer. Many pharmaceutical drugs have the tendency to exhibit polymorphism which is unwanted for pharmaceutical companies, where they have experienced market shortages due to these unpredicted polymorphic and/or pseudomorphic changes. The property of a drug exhibiting more than one crystal form is considerably regarded as polymorphism and each of the crystalline form has its own physicochemical properties, namely, solubility, heat capacity, melting point, and sublimation point. To relieve this ultimate effect on the drug quality and stability, a prior detection of polymorphism in the final dosage form is highly recommended. Hence, many analytical techniques have been proposed for the detection of polymorphism in pharmaceutical drug products.

Methods: Fourier transform (FT)-Raman spectrometer is used for the investigation of drug polymorphism and the instrument is advanced with charge coupled device detectors, ease of sample preparation and handling, mitigation of sub-sampling problems using different geometric laser irradiance patterns and having different optical components of Raman spectrometers.

Results: In this work, we carefully studied the Raman spectral patterns for Lamivudine as well as Finasteride drug substances for the detection of polymorphism. Further, we have highlighted the advantages of FT-Raman spectroscopy over other polymorphism detection techniques. For example, Raman spectra showed invariably sharp, well resolved bands compare to IR spectra due to the minor contribution of overtone vibrations in Raman spectra, resulting in much less broadening and a better resolution of bands. Besides, Raman spectroscopy does not suffer from the sampling problems that are common in X-ray powder diffraction, where preferred orientation and specimen displacements are serious restrictions for the application of quantitative method.

Conclusion: Here, in this paper, we are presented and compared the experimental results regarding the detection of polymorphism in Lamivudine and Finasteride drugs using FT-Raman spectroscopy, to illustrate the advantages of the technique in the detection of polymorphism over other techniques.
CASE STUDY: ORGANOPHOSPHATE POISONING – ATROPINE-INDUCED PSYCHOSIS IN INTENSIVE CARE UNIT PATIENT
Authors: PORANKI VATHSALYA
Published: January 2021

Organophosphate compounds are used as commercial insecticides and applied as aerosols or dust. Consuming these compounds intentionally or unintentionally lead to dangerous conditions even to fatality. The most common obstacle in treating organophosphorus poisoning is the availability of sufficient medical care, equipment to provide proper emergency care observed in rural areas where there is a lot of gap between intensive care and acute care. Atropine use is as an antidote in organophosphorus poisoning. The dose of atropine mainly depends on the organophosphorus toxic doses. Atropine is a competitive antagonist of acetylcholine at the muscarinic postsynaptic membrane. Atropine blocks all the muscarinic effects in the body. This study presents a case of organophosphorus poisoning treated with atropine leading to atropine psychosis. Patient’s conditions, outcomes, and improvements are studied.
Review POTENT PHARMACEUTICAL PRODUCTS FROM AQUATIC PLANTS – REVIEW
Authors: K SAXENA MANJULA , SINGH NEERJA , KUMAR SUDHIR , MP DOBHAL , DATTA SOUMANA
Published: January 2021

Several biologically active secondary metabolites from aquatic plants have been extracted and identified using modern instrumental BioTechniques and used in various ways as flavors, food, additives, coloring agents, nutraceuticals, cosmetics, and also as unique source of pharma industries for the discovery or development of new drugs. From algae to aquatic macrophytes belonging to various categories, aquatic plants produce a variety of compounds such as polyketides, peptides, alkaloids, flavonoids, phenolic compounds, terpenes, steroids, quinones, tannins, coumarins, and essential oils commercially involving in antibiotic, antiviral, antioxidant, antifouling, anti-inflammatory, anticancer, cytotoxic, and antimitotic activities; thus making them a rich source of medicinal compounds. Moreover, they are comprehensively used in human therapy, veterinary, agriculture, scientific research, and in countless areas. Importantly these chemicals are exercised for developing new antimicrobial and cancer drugs. Furthermore, antioxidant molecules in aquatic plants and seaweeds have recently been acknowledged. This review contains a consolidated contemporary document consisting of entire knowledge available on pharmaceutical products of aquatic plants and highlights major differences among secondary metabolites found in aquatic (algae) and terrestrial plants.
A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION OF TYPE- II ANTIDIABETIC DRUGS IN PHARMACEUTICALS AND BIOLOGICAL MATRICES
Authors: RAMAKRISHNA BADIKELA , MONDAL SUMANTA
Published: January 2021

Its a meglitinide analog is an oral symptom designed to common hour aldohexose excursions. Through not an antidiabetic, it acts in AN analogous manner by binding to antidiabetic receptor likewise on alternative one distinct receptor-» closure of adenosine triphosphate dependent K+ channel-» of depolarization-» internal secretion unharnesses. Repaglinide induces fast onset short-lasting internal secretion discharged. It is administered antero every main meal to stabilize postprandial hyperglycemia; the dose ought to be emitted if a food material is incomprehensible. Because of less permanent action, it perhaps had a lower risk of the seriousness of hypoglycemia. Repaglinide is indicated solely in type-II DM as another to sulfonylureas, or to supplement metformin/long internal secretion. It ought to be avoided in disease. This review delivers a detail description totally different of various analytical ways were printed for the estimation of repaglinide and its combination medicine in prescription drugs and biological matrices. This assessment encompasses different analytical ways such as chemical analysis ways, aggressive liquid activity (HPLC), superior thin-layer activity (HPTLC), liquid chromatography-mass spectroscopic analysis (LC-MS), and ultra-performance liquid activity (UPLC), GC-MS, [LC-ESI-MS-MS], capillary activity (CE), titrimetric and chemical science technique, and designation study for the estimation of repaglinide and together with a mixture.
EXPLORING THE INTEGRATIONS OF MALL INTO ENGLISH TEACHING AND LEARNING FOR INDONESIAN EFL STUDENTS IN SECONDARY SCHOOLS
Authors: Biantoro Bramy
Published: January 2021

The use of mobile technology for education is on the rise across the world, especially in Indonesia. However, there are concerns in making such an educational revolution as mobile technology may introduce negative side effects to the Indonesian students. Also, only a few studies have discussed the use of mobile technology in Indonesian secondary schools. Those circumstances potentially make many stakeholders doubt the proper implementation of mobile technology-based learning and the possible challenges, especially in English as a foreign language (EFL) classroom. Thus, this paper is aimed to provide theoretical insights into the implementation of mobile-assisted language learning (MALL) for secondary school students in EFL classrooms. A secondary source analysis through systematic review was employed to generate the findings, focusing on MALL and EFL primary research and government documents related to education in secondary schools. Based on the findings, this paper offers an improved teaching and learning approach based on collaborative learning and task-based language teaching (TBLT) to facilitate better implementation and integration of MALL in EFL classrooms. In addition, the findings also show possible challenges during the implementation of MALL in Indonesia for future considerations, such as the technology readiness of EFL stakeholders and teachers’ pedagogical issues related to mobile learning. Lastly, this paper is expected to raise awareness of MALL opportunities and open more paths for more primary research regarding the implementations of MALL in Indonesian EFL classrooms.
A TRANSITIVITY ANALYSIS OF GRETA THUNBERG’S 2019 CLIMATE ACTION SUMMIT SPEECH
Authors: Karisa Ardelia , Lauwren Stefanny
Published: January 2021

Climate change has been one of the most significant concerns for the United Nations. As a result, the United Nations held a summit in 2019, inviting several notable speakers in the field. One of them is a young teenager from Swedish, Greta Thunberg. Greta Thunberg is a prominent climate activist who delivered a speech at the United Nations Climate Action Summit 2019, which is about how people and the government need to limit global warming. Her address became viral and garnered attention from many media, and roused a massive youth-led climate rally. Thus, this study analyzed her speech as the object of the study and employed a descriptive qualitative method. The study scrutinized 54 clauses through transitivity analysis from Hallidayan Systemic Functional Grammar (SFG) to understand the processes in the address and its function. This current study has revealed that the speaker’s dominantly used material process (37%) to describe the damage to the environment done by people. The use of relational process (31.5%) describes climate change's effects on the world and her life. The mental process used in 16.7% of the data provokes guilt and responsibility, as she pointed the audience as the actors that cause climate change. The behavioural process (7.4%) shows that Thunberg will not stay quiet on climate crisis when her generation is the one who will suffer from it. Existential process (3.7%) is used to describe the existing problems, while verbal process (3.7%) is used in quoting the high-profile politician to prove that none of their promises have been fulfilled.
Restorasi Ideologi Pancasila Dalam Pemiki Ahmad Syafi'i Ma'arif
Authors: Yusuf Nurbani
Published: January 2021

Penelitian ini membahas mengenai restorasi pemikiran Ahmad Syafii Maarif selaku anggota dewan Pengarah Badan Pembinaan Ideologi Pancasila terhadap Pancasila sebagai ideologi. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif. Sedangkan metode penelitian adalah deskriptif. Adapun hasil dalam penelitian ini adalah Restorasi Ideologi Pancasila dalam pemikiran Anggota Dewan Pengarah Badan Pembinaan Ideologi Pancasila yakni Ahmad Syaf’I Ma’arif merupakan usaha berpikir kritis dalam mengejawantahkan dan mengembangkan ideologi Pancasila agar mampu bertahan dengan kondisi perubahan zaman. Pengejawantahan yang di lakukan oleh Ahmad Syaf’I Ma’arif merupakan suatu bentuk pemikiran yang sistematis, metodis dan valid dalam mengembangkan ideologi Pancasila agar dapat tetap relevan dengan kondisi dan tantangan zaman. Dengan tujuan agar ideologi Pancasila dapat terus membumi atau dapat di tarik kebumi sehingga Pancasila sebagai ideologi negara dapat benar-benar menjadi pedoman dalam kehidupan bermasyarakat, berbangsa, dan bernegara. Sehingga tujuan akhir yakni keadilan sosial bagi seluruh rakyat Indonesia dapat segera atau mengalami percepatan dalam laju gerak langkah negara ini.
Peran Organisasi Gerakan Mahasiswa Nasional Indonesia Dalam Mentransformasikan Nilai-Nilai Pancasila Di Universitas Muhammadiyah Malang
Authors: Wibowo Arif Prasetyo , Djuyandi Yusa , Agustino Leo
Published: January 2021

Tujuan dalam penelitian ini adalah untuk mengetahui dan menganalisis peran Organisasi Gerakan Mahasiswa Nasional Indonesia di Universitas Muhammadiyah Malang dalam mentransformasikan nilai-nilai Pancasila kepada para kadernya. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Dengan temuan penelitian peran organisasi Dewan Pimpinan Komisariat Gerakan Mahasiswa Nasional Indonesia Universitas Muhammadiyah Malang dalam mentrasformasikan nilai-nilai Pancasila dilakukan dengan bentuk Program Kerja disetiap periode kepengurusan organisasi yang dapat dilihat melalui lima indikator dalam teori peran, yakni aksi, patokan, penilaian, paparan, dan sanksi.
Islamic Economics Ethics Perspective on Economic Development in the Time of Coronavirus Disease (Covid-19)
Authors: Hakim Rahmad , Muslikhati Muslikhati , Aprilianto Fitrian
Published: January 2021

This study aims to provide an in-depth analysis of Islamic economics ethics on economic development in the time of coronavirus disease (Covid-19). This research was qualitative, using documentation techniques in data collection. The data analyzed using descriptive-qualitative technique. The conclusion of this study found that Islamic economic ethics in the economic development emphasizes on the role of the invidual (society) and institutions (government) in an active effort to manage the spread of coronavirus disease (Covid-19) by avoid an excessive buying, consume the halal and thayyib food, increase the alms giving activites and also the enforcement of fiscal and monetary policy.
Implementation of Integrative Arabic Grammar (Nahwu & Sharaf) Curriculum in Islamic Boarding School
Authors: Ardiansyah Ade Arip , Muhammad Azhar
Published: January 2021

Learning Nahwu & Sharaf is considered a frightening subject by students in Islamic boarding schools and informal Islamic boarding schools. One of the reasons is that the institution's existing curriculum has not been planned and presented correctly. One of the institutions with an integrative curriculum to teach Nahwu & Sharaf subjects considered acceptable is the Darul Uluum Islamic Boarding School.This study aimed to describe Nahwu & Sharaf curriculum development concepts and models at Daarul Uluum Islamic boarding school at Majalengka supporting and inhibiting implementing the curriculum. The method used in this study was qualitative research. Data collection used interviews, the teacher's approach to teaching Nahwu & Sharaf, and the Islamic boarding school syllabus.The results showed that Nahwu & Sharaf curriculum development model was a central de-central, which combined two administrative approaches and the grassroots approach. The supporting factors were: 1) Motivation of leaders of Islamic boarding school; 2) Commitments of leaders of Islamic boarding schoolto develop curriculum, 3) Professional competence of Nahwu & Sharaf teachers, and 4) Input of students who have an initial understanding of the material to be obtainable. The inhibiting factors were: 1) the lack of individual funding allocations; 2) the teacher has not been able to properly teach students the material in Nahwu & Sharaf syllabus; 3) the unequal ability of teachers to teach in class Nahwu & Sharaf subjects; and 4) students feel bored while studying in class.
Model Pembelajaran Numbered Heads Together (NHT): Pengaruh Terhadap Hasil Belajar Tematik Siswa SD
Authors: Rohmanurmeta Fauzatul Ma'rufah
Published: January 2021

Penciptaan interaksi agar siswa aktif dapat dilakukan melalui model pembelajaran. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Numbered Heads Together (NHT) terhadap hasil belajar tematik siswa kelas IV SDN Nglayang 1 tahun 2018/2019. Jenis penelitian ini adalah kuantitatif dengan eksperimen sebagai metode penelitian. Populasi dalam penelitian ini adalah seluruh siswa SD Negeri 1 Nglayang dan SD Negeri 2 Nglayang kelas IV yang masing-masing berjumlah 22 dan 23 siswa. Dengan sampel menggunakan teknik sampling jenuh, sehingga sampel berjumlah 45 siswa. Data hasil belajar tematik diperoleh dari teknik tes berupa pilihan ganda. Analisis data diuji menggunakan uji-t. Analisis selisih rata-rata diperoleh tobs = 6,77 α = 0,05 dan DK = {t | t <-2.07 atau t> 2.07}. Karena DK DK, H0 ditolak. Berdasarkan data tersebut dapat disimpulkan bahwa terdapat pengaruh model pembelajaran Numbered Heads Together (NHT) terhadap hasil belajar tematik
The relationship between self-regulated learning and learning motivation with metacognitive skills in biology subject
Authors: Mustopa Nanda Mulyadi , Mustofa Romy Faisal , Diella Dea
Published: January 2021

The latest learning in the 21st century requires learners to master various competencies to support their learning process and achieve the expected learning goals. This study aims to determine the relationship between self-regulated learning and learning motivation with metacognitive skills. The research was conducted in May 2020 at SMAN 1 of Tasikmalaya. The research used a quantitative approach to explore the correlation among variables observed involving a population of 177 students of class XI MIPA 1- XI MIPA 5 in academic year 2019/2020. The samples were 43 students selected using simple random sampling technique. Metacognitive Awareness Inventory (MAI) questionnaire adapted from Schraw & Dennison and Motivated Strategies for Learning Questionnaire (MSLQ) adapted from Pintrich & De Groot were used to collect the data. MAI is used to measure metacognitive skills, while MSLQ is used to measure self-regulated learning and learning motivation. MLSQ is a validated isntrumen, while MAI is tested for validity first and the results are valid. The analysis technique used was multiple linear regression tests. The results show that the correlation coefficient (R) was 0.747 and the coefficient of determination (R2) was 0.558. The contribution of self-regulated learning and learning motivation to metacognitive skills amounted to 55.8%.
Student’s environmental literacy based on Adiwiyata and non-Adiwiyata at senior high school in Sleman, Yogyakarta
Authors: Astuti Dwi , Aminatun Tien
Published: January 2021

Environmental problems in Indonesia increase the government's efforts in shaping students' environmental care character through the Adiwiyata program. This study was conducted to determine differences in environmental literacy between Adiwiyata and non-Adiwiyata schools in Senior High School (SHS) in Sleman Regency, Yogyakarta. This survey research using a conventional sampling technique. The sample involved in this study was 1,568 students from nine schools in Sleman Regency. The data collection instrument refers to the instrument developed by the North American Association for Environmental Literacy (NAAEE) and is supported by interviews and observations. Measurement of environmental literacy in this study was carried out in two domains: competence and disposition. Comparative data analysis used the Mann Whitney test assisted by SPSS 25 for windows. The results showed that students' environmental literacy in the Sleman Regency was included in the good category in the competency and disposition domain. Environmental literacy abilities in Adiwiyata and non-Adiwiyata schools differ, both in the competency domain which includes competence (sig <0.05) and environmental literacy (sig 0.002), and in the disposition domain with sig <0.05. These results concluded that there were differences in students' environmental literacy skills between Adiwiyata and non-Adiwiyata schools. This research recommends that schools initiate programs to strengthen environmental literacy through strengthening the character of caring for the environment.
Sampul Depan 36 1 2018
Authors: Puspitasari Santi
Published: January 2021

Sampul Depan 36 1 2018
Sampul Belakang 36 1 2018
Authors: Puspitasari Santi
Published: January 2021

Sampul Belakang 36 1 2018
Sampul Belakang 36 2 2018
Authors: Puspitasari Santi
Published: January 2021

Sampul Belakang 36 2 2018
BH678: Big History in the Italian Middle Schools: A Manifesto against the Fragmentation of Knowledge
Authors:   Scuola Secondaria di Primo Grado“Segantini”, Nova Milanese, Italy, Vismara Paolo
Published: January 2021

With the Big History Italia BH678 Project I have introduced the Big History approach in the Italian middle schools, proposing an interpretation of the history of the universe as a way of creating a complex fusion among the sciences and a symbolic path for personal and spiritual growth. Starting from a deep love for complexity, I have written a novel, Storia interiore dell’Universo (now in print for the Italian market), that brings Big History into a poetic and psychedelic landscape. If you want to know the universe, probably, sometimes your body, your brain, your matter are enough; but if you desire to learn from the universe and you work in education, you should consider the whole Homo sapiens, as I believe our species learns only through feeling. Each Big History threshold is an opportunity to feel the echo of some keywords that contribute to developing our Inner Big History, taking off from apparently outer island-moments scattered across spacetime.
GESTIÓN PÚBLICO PRIVADA; DESARROLLO E INSERCIÓN INTERNACIONAL. EL DEL POLO INFORMÁTICO DE TANDIL
Authors: Barrios Micaela , De Angelis Ignacio
Published: January 2021

El artículo analiza la dinámica de articulación público privada en torno al surgimiento y consolidación del Polo Informático en la ciudad argentina de Tandil. La hipótesis que guía el trabajo sostiene que el desarrollo local del sector de Software y Servicios Informáticos superó su ponderación inicial como modelo de negocio y prosperó hacia un proyecto de desarrollo estratégico para la ciudad y su inserción internacional. Los hallazgos muestran que la interacción lograda entre la universidad; el municipio y las empresas; permitió el impulso competitivo del sector; promoviendo al mismo tiempo a Tandil como una marca de exportación de software y servicios tecnológicos de calidad.
¿DÓNDE ESTÁN Y QUÉ HACEN LAS MUJERES DENTRO DE LA ADMINISTRACIÓN PÚBLICA? EL CASO DEL SECTOR PÚBLICO ARGENTINO
Authors: Chudnovsky Mariana
Published: January 2021

Argentina es uno de los países con mayor igualdad de género; sobre todo; debido al aumento en la paridad de género en el Poder Legislativo. Sin embargo; esto no se traduce al Poder Ejecutivo: el país no solo muestra una baja posición; sino también una disminución de mujeres en posiciones ministeriales. Este artículo describe la situación de las mujeres en todos los niveles de la rama ejecutiva con el objetivo de identificar dónde están las mujeres; qué están haciendo y cuánto ganan por su trabajo. Los hallazgos más significativos son que los hombres ocupan la mayoría de las posiciones del gabinete político y de las posiciones gerenciales. En el nivel burocrático; se observa que las mujeres tienen más grados universitarios que los hombres; se concentran en los niveles más bajos de la jerarquía (el escalafón vigente) y ganan menos que los hombres en la misma posición
La Universidad Estatal a Distancia y la educación superior de las mujeres en Costa Rica
Authors: Zúñiga Muñoz Xinia
Published: January 2021

El artículo destaca la composición mayoritaria de mujeres en la matrícula de la UNED y los desafíos que ello plantea en términos de la oferta y los servicios institucionales. Inicia además un acercamiento a las características psicosociales relacionadas con experiencias de abuso, de las estudiantes de un curso perteneciente a dos de las carreras de mayor matrícula en la UNED, e intenta los primeros vínculos entre tales características y la experiencia de ser estudiante a distancia.
Educación a distancia: algunos desafíos teóricoprácticos
Authors: Bolaños Calvo Bolívar
Published: January 2021

Este artículo trata de brindar al lector una contextualización o marco de referencia en el cual se está desarrollando la modalidad de educación a distancia. Por otro lado, pretende dar a conocer las ventajas o alcances y desventajas o aspectos que deben rechazarse de la modalidad educativa. Intenta rescatar la función o el papel preponderante de ésta como una opción válida para que muchas poblaciones tengan la oportunidad de ingresar en el concierto del proceso educativo para aumentar su calidad de vida y actuar en la sociedad más responsablemente. También plantea la trascendencia e importancia, así como la repercusión que ha tenido y tendrá el ingreso de la tecnología o las innovaciones tecnológicas, en el proceso de enseñanza-aprendizaje en dicha modalidad, la cual será un instrumento de la mediación pedagógica y no un fin como a veces se pretende. Por último, intenta rescatar enfoques modernos entre los que se encuentra una visión constructivista del aprendizaje como herramienta válida en el desarrollo de  las habilidades y destrezas de los estudiantes.
Richter’s Transformation as leptomeningeal infiltration in a Chronic Lymphocytic Leukemia patient receiving Venetoclax. Could blood-brain barrier be a disease “sanctuary” during Venetoclax treatment?
Authors: Dimou Maria , Bitsani Aikaterini , Roumelioti Maria , Dimitrakopoulou Aglaia , Iliakis Theodoros , Pardalis Vasileios , Grafakos Ioannis , Kalyva Sotiria , Markopoulos Athanasios , Kyrtsonis Marie-Christine , Panayiotidis Panayiotis
Published: January 2021

We present a unique Richter’s transformation case in CNS with identical
to CLL clonal origin in a patient treated with Venetoclax. With our case
we make implications on whether Venetoclax penetrates the blood-brain
barrier and we address the debating issue of the appropriate Venetoclax
dose in case of drug-drug interactions.
Oral manifestations and dental care management of a young patient with lymphangioma of the tongue: A case report.
Authors: Chouchene Farah , Masmoudi Fatma , Baaziz Ahlem , Maatouk Fethi , Ghedira Hichem
Published: January 2021

Lymphangiomas of the tongue are very rare tumors usually diagnosed in
infancy and early childhood. Children with Lymphangiomas of the tongue
may require multidisciplinary care and a close collaboration between
physician and dentist to be able to eradicate any sources of dental
infections before undertaking medical treatment.
Is prediction of local recurrence possible in Paget's disease of the breast?
Authors: TURANLI SEVIM
Published: January 2021

Purpose Mammary Paget disease of the breast is rare form of breast
cancer. Recent trends in the management have changed from mastectomy to
breast conserving surgery, its safety is still controversial. The study
aimed to predict the patients prone to local recurrence, and to find out
the answer to the question of who should be a candidate for breast
conserving surgery. Methods Between January 2007 and December 2017, 69
patients who underwent surgery and pathology report diagnosed as Paget’s
disease, were analyzed retrospectively. As factors that may affect local
recurrence; age, presence of nipple symptoms, mass detection in
radiological imaging, type of the surgery, stage, pathological findings
of the tumor (histological type, multicentricity, ER, PR, HER2, Ki 67
proliferative index, molecular subtype) were evaluated. Results Among 69
patients, 26 patients had ductal carcinoma in situ and others had
invasive ductal carcinoma. Number of the patients underwent breast
conserving surgery and mastectomy was 15 and 54 respectively. Patients
were followed-up for a median time of 45 months. Recurrence was
developed in 12 patients, half of them with local recurrence. Type of
the surgery was the unique factor influencing local recurrence
(p=0.001). Subgroup analysis was performed among patients undergoing
breast conserving surgery, only Ki 67 proliferative index above 30
(p=0.002) was found to affect local recurrence. Conclusion Although the
number of patients is small, it should be kept in mind that local
recurrence may be high when BCS is performed in patients with the
tumor’s Ki 67 proliferative index is above 30.
Nonadaptive radiation of the gut microbiome in an adaptive radiation of Cyprinodon pupfishes with minor shifts for scale-eating
Authors: Heras Joseph , Martin Christopher
Published: January 2021

Adaptive radiations offer an excellent opportunity to understand the
eco-evolutionary dynamics of gut microbiota and host niche
specialization. In a laboratory common garden, we compared the gut
microbiota of two novel trophic specialists, a scale-eater and a
molluscivore, to a set of four outgroup generalist populations from
which this adaptive radiation originated. We predicted an adaptive and
highly divergent microbiome composition in the specialists matching
their rapid rates of craniofacial diversification in the past 10 kya. We
measured gut lengths and sequenced 16S rRNA amplicons of gut microbiomes
from lab-reared fish fed the same high protein diet for one month. In
contrast to our predictions, gut microbiota largely reflected 5 Mya
phylogenetic divergence times among generalist populations in support of
phylosymbiosis. However, we did find significant enrichment of
Burkholderiaceae bacteria in both lab-reared scale-eater populations.
These bacteria sometimes digest collagen, the major component of fish
scales, supporting an adaptive shift. We also found some enrichment of
Rhodobacteraceae and Planctomycetacia in lab-reared molluscivore
populations, but these bacteria target cellulose. Minor shifts in gut
microbiota appear adaptive for scale-eating in this radiation, whereas
overall microbiome composition was phylogenetically conserved. This
contrasts with predictions of adaptive radiation theory and observations
of rapid diversification in all other trophic traits in these hosts,
including craniofacial morphology, foraging behavior, aggression, and
gene expression, suggesting that microbiome divergence proceeds as a
nonadaptive radiation.
Cuarentena por COVID-19 y la necesidad de mejorar el soporte psicológico en Latinoamérica
Authors: Figueroa-Quiñones Joel
Published: January 2021

Carta al editor
A Case Study in Managing the Analytics “Iceberg”: Data Cleaning and Management using Alteryx
Authors: O'Brien Ann , Stone Dan N.
Published: January 2021

This case introduces accounting students to data management using a “no code” approach. Many tools can be used for extract, transform, load (ETL) processes. Herein, we introduce ETL using Alteryx Designer, a market-leading tool for managing and manipulating data. In the case, students learn basic data cleaning and joining skills, explore key data management concepts including workflows and metadata, and learn how to create and document workflows in Alteryx. Undergraduate or graduate accounting students who have basic database knowledge (e.g., in an introduction to accounting systems class) and data processing skills will benefit from the case. Evidence from use suggests that the case is relevant, challenging, and useful for the goal of teaching introductory and intermediate-level ETL skills, using Alteryx. The case is easy to implement and an important resource for teaching data management and Alteryx Designer.
Surgical-orthodontic treatment for severe malocclusion in a patient with osteopetrosis and bilateral cleft lip and palate:
Authors: Kim Jin-Kyu , Kim Jun-Young , Jung Hwi-Dong , Jung Young-Soo
Published: January 2021

Orthognathic surgery in patients with craniofacial osteopetrosis, a condition associated with osteoclast dysfunction, is usually avoided because of the risk of osteomyelitis. A 19-year-old woman presented with the chief complaint of severe malocclusion and anterior crossbite. After radiographic evaluation, craniofacial osteopetrosis was diagnosed. Surgical-orthodontic treatment was performed after meticulous history taking and verification of normal bone turnover using bone-metabolism markers for endocrine evaluation. Favorable esthetic and functional outcomes were achieved.
Pengembangan Virtual Reality untuk Digitalisasi Pura Penataran Agung di Pura Besakih
Authors: Raditya I Wayan Andika , Darmawiguna Gede Mahendra , Sindu I Gede Partha
Published: January 2021

Pengembangan Virtual Reality untuk Digitalisasi Pura Penataran Agung bagian Mandala 1, 5, 6 dan 7 merupakan salah satu pemanfaatan teknologi yang digunakan sebagai media konservasi untuk melestarikan Pura Penataran Agung bagian Mandala 1, 5, 6 dan 7 sebagai bagian dari Pura Agung Besakih dan juga sebagai warisan budaya. Media berupa aplikasi Virtual Reality ini mengajak pengguna untuk dapat melihat keadaan Pura Penataran Agung Besakih bagian Mandala 1, 5, 6 dan 7 dengan detail selain itu pengguna juga dapat melakukan perpindahan ke arah mana yang ingin dilihat sehingga dirasakan sebuah pengalaman seolah-olah berada di Pura Penataran Agung Besakih bagian Mandala 1, 5, 6 dan 7. Pengembangan Virtual Reality untuk Digitalisasi Pura Penataran Agung Besakih bagian Mandala 1, 5, 6 dan 7 menggunakan metode waterfall. Pengujian penelitian ini menggunakan 6 tahapan proses pengujian : (1) Uji whitebox dengan penerapan di setiap prosesnya sudah sesuai, (2) uji blackbox dengan 5 responden didapat hasil tidak terdapat kesalahan, (3) uji usability dengan 5 responden di dapat rata-rata persentase 80% termasuk baik, (4) uji performance efficiency dengan 5 responden didapatkan rata-rata persentase 86% termasuk sangat baik, (5) uji data integrity dengan 2 responden ahli di dapat rata-rata persentase 89% termasuk sangat baik(6) uji User Experience Questionnaire (UEQ) di dapat persentase rata-rata dari 20 responden dengan hasil positif.
Implementasi Forward Chaining untuk Mendiagnosis Penyakit Tanaman Kopi
Authors: Novianti Kadek Dwi Pradnyani , Gunawan I Made Deddy Karunia , Sukerti Ni Kadek
Published: January 2021

Pengembangan usaha tani kopi khususnya di daerah Kintamani yaitu di Subak Desa Belantih mejadi perhatian besar karena melihat komoditi kopi menjadi komoditi utama yang dihasilkan dari daerah ini. Namun teknik budidaya tanaman kopi Arabika di daerah Kintamani masih kurang memadai sehingga menimbulkan berbagai gangguan pertumbuhan tanaman.Salah satunya adalah penyakit tanaman. Petani tanaman kopi Arabika di daerah Kintamani memliki sedikit informasi yang berkaitan dengan penyakit tanaman kopi sehingga penanganannya menjadi tidak sesuai. Untuk mengatasi hal ini kemudian dibangunlah system pakar yang mengimplementasikan metode forward chaining untuk mendiagnosis penyakit tanaman padi. Sistem dibuat berbasis web dengan basis data MySQL dan PhpMyAdmin. Setelah system berhasil diimplementasi maka dilakukan pengujian menggunakan blackbox testing. Hasil pengujian menunjukan bahwa semua fungsi-fungsi yang ada dapat berjalan sesuai dengan yang diharapkan.
Perencanaan Masterplan Teknologi Informasi pada Pemerintahan Desa Berbasis E-Government
Authors: Putra I Gede Juliana Eka , Putra Made Adi Paramartha , Juliana I Ketut Agus
Published: January 2021

E-Government merupakan salah satu langkah pemerintah untuk dapat memberikan pelayanan kepada masyarakat dengan memanfaatkan teknologi khususnya Website. Salah satunya adalah penerapan e-Government pada pemerintahan yang paling kecil yaitu Desa. Desa sebagai ujung tombak pemerintahan di Indonesia sudah seharusnya menggunakan e-Government sebagai pelayanan kepada masyarakat sehingga dapat mudah diakses dan cepat. Namun dari hasil penelitian terakhir yang dilakukan penerapan e-Government masih belum maksimal pada tingkat pemerinahan Desa. Penelitian ini mengambil studi kasus di Desa Batungsel Tabanan yang merupakan salah satu desa yang belum menerapkan e-Government untuk sistem pemerintahannya. Banyak faktor yang menyebabkan mulai dari anggaran hingga Sumber Daya Manusia yang belum memadai. Penelitian ini menggunakan metode deskriptif kuantitatif yaitu dengan menggunakan metode-metode yang sistematis untuk mendapatkan untuk dilakukan analisis kemudian dijadikan patokan pengembangan e-Government. Dari Analisis yang dilakukan Desa Batungsel masih belum memadai dari segi infratruktur, Sumber Daya Manusia dan juga anggaran. Pada masterplan e-Government yang akan direncanakan diberikan skala prioritas pembangunan sehingga sesuai dengan kebutuhan desa dan bermanfaat baik bagi pemerintah ataupun masyarakat Desa Batungsel.
Development of labor potential in the context of digitalization of the Russian economy
Authors: Nikitskaya Elena F. , Sorokina N. Yu. , Valishvili Mary A.
Published: January 2021

The article is devoted to the study of theoretical and practical aspects of the transformation of labor potential and staffing in the process of formation of the digital economy. The authors identified the professional and user areas of application of digital technologies, substantiated their relationship with organizational and managerial innovations. The prerequisites for the widespread dissemination of information and communication technologies and the development of innovative networks are substantiated.
Applications of Mathematics Charged Islamic Values by Using Macromedia Flash and Camtasia
Authors: Durri Agus Ahmad , Raharjo Hendri , Muchyidin Arif
Published: January 2021

Some factors of low interresting of Mathematic learning material for student on Junior High School grade (SMP/MTs) are design of learning material that is less animation and  the difficuties of use the learning material. Therefore, the use of learning material should be inovated for increasing the learners’ interrest, to make them easy understanding the subject that has been learnt, and still capable to increase reigion value in their ownselves. One form of this effort is to create learning material in the form of flash mathematics with consits Islamic value. Flash application is an application that can be developed in accordance animatif developer creativity. The purpose of the research is the developing of learning material in the electric learning form that consists Islamic value in Transformation subject. The method of research is research and development, and the design of the research is using the steps of ADDIE model, there are analysis, design, development, implemetation, and evaluation. Data collection techniques included interviews and observations with research instruments are questionnaires, observation sheets and tests. Further analysis of the data conducted by researchers consists  of qualitative and quantitative analysis to determine the feasibility and effectiveness of the teaching materials developed. The results of the expert evaluation consisting of a material expert and a media expert, shows that the average velue obtained from every aspects: content quality and purpose,instructional quality of learning material, aspects of the charge Islamic value, and the technique quality was 4.37 that very good category. The results of the assessment by the teachers of Junior High School grade (MTs) Nurul Huda Munjul which consist of two Mathematics teacher and a teacher of Information and Communication Technology (ICT), shows that the average velue of each aspect was 4.46 with very good category. Than the student quationnaire responses result data obtained by the average velue of each aspects: the quality of learning and instructional, technical aspects of the display, and payload  integrition aspects of Islamic value in learning material, namely 3.98, with good categories. The data test scores of student learning outcomes gained an average of 82.34  > KKM (75) with the classical completeness of 89.19% > 85%. The conclusion showed that the quality of Mathematic learning materials charged Islamic velues are developed with macromedia flash and catamsia aplications is feasible and effective to be used in the learning process.
Pembuatan Perangkat Lunak Sistem Informasi Penjualan Tunai Berbasis WEB Di PT. Propan Raya Cirebon
Authors: Sokibi Petrus
Published: January 2021

he rapidly Technology Progress, especially in Computer, is very useful to the human in doing their job. Nowadays, the global era, every business needs a tool, Computer,  to support their activities, especially to process data and information. In this research, the writer presents the topic titled: ”The Building of Software for Information System in Cash Selling by using WEB at PT. Propan Raya Cirebon” as the development of the existing system from manual to the computerized system. This system is built by using PHP language program and MySql as the database storage. In this application, the user can process the selling transaction, input goods, and consumer data. When the transaction is being processed, the system will process the updating of stock in the database automatically, meanwhile, the user can determine the stocking in the store directly. Based on the research done on the trial, the Information system of cash selling has been successfully processed.