bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of shaping ability and cutting efficiency of a novel rotary file system (Trunatomy) versus Protaper Next and 2Shape in severely curved mandibular mesiobuccal canals (An in vitro study)
Authors: Ewis Rana Mohamed , Lutfy reem ahmed , Elkhodary sherif adel , Elkhodary sherif adel
Published: March 2023

Introduction:This study aimed to compare the shaping ability and cutting efficiency of Trunatomy, Protaper Next and 2Shape file systems in preparing severely curved canals.Methods:Forty-five mandibular mesiobuccal canals with 40-60 degrees of curvature were divided into three equal groups: Trunatomy, Protaper Next and 2Shape. Pre- and post-instrumentation images were taken using cone beam computed tomography to measure canal transportation, centering ability, dentin thickness and canal curvature radius and volume. Pre- and post-instrumentation weights were measured using ananalytical scale.Results:Trunatomy had significantly the lowest values of canal transportation, amount of removed dentin and percent change in canal curvature radius and volume. Protaper Next had significantly the highest buccolingual canal transportation. There was no significant difference among the three systems in canal centering. Trunatomy significantly recorded lesser percent change in root canal weightthan 2Shape.Conclusion:The three file systems were able to prepare severely curved root canals efficiently and safelyClinical relevance:Trunatomy system can prepare root canals with severe curvature and complex anatomy with minimal amount of removed dentin.
D2D Lifetime Analysis in context of Radio Frequency Energy harvesting
Authors: CHINBOU ABDELKARIM , BOUMAALIF Adil , ZYTOUNE Ouadoudi
Published: March 2023

Device-to-device (D2D) communication has been recognized as one of the promising paradigms for supporting the next generation of cellular networks, it brings several benefits in terms of reducing time delay for communication, and providing better spectrum efficiency. However, energy consumption in D2D communication is a big challenge due to the limited operational lifetime of the devices’s batteries. Many techniques have been proposed in literature to improve energy efficiency such as harvesting energy from ambient sources like wind, solar, and vibration. Recently a new technique named Wireless Power Transfer (WPT) has emerged as a solution to the limitations of the old energy harvesting strategies. It promised to ensure the availability of sufficient energy at the user terminals whenever required. This article used stochastic geometry to analyze the transmitter device’s lifetime in the context of D2D under laid communication mode and to stand out the outcome of the RF energy harvesting model on the device’s lifetime. First, the expression of expected transmit power was proved using its cumulative distribution function, then the lifetime of transmitting devices under Rayleigh fading has been derived. Furthermore, the effect of the RF energy harvesting model on extending the device’s lifetime has been highlighted. Finally, analytical and simulation studies are realized to prove the value of our analysis.
In vitro antimicrobial activity evaluation of selected medicinal plants against multidrug- resistant isolate of Clinical Bovine Mastitis
Authors: Balcha Fikre Birhanu , Sulayeman Mishamo , Neja Sultan Abda
Published: March 2023

Background
Mastitis is one of the challenges impairing the development of the dairy industry. Among mastitis-causing bacteria, S. aureus and E. coli represent the main causative agents that threaten the farmers not only due to the high incidence rate and zoonotic potential but also due to reports of multi-drug resistance. The study was conducted to assess the antimicrobial activity of selected medicinal plants against multidrug-resistant bacterial isolates from clinical bovine mastitis. Milk samples from mastitis cases were aseptically collected and S. aureus and E .coli isolates were identified, the antibiotic sensitivity test pattern of the isolate were confirmed. Four medicinal plants were collected; extracted and their in vitro effectiveness on multidrug-resistant S. aureus and E. coli isolates of bovine mastitis was validated compared to the conventionally used antimicrobial drugs.
Results
Crude extracts from the four plants were effective against both susceptible and resistant isolates. Extract of Crotona macrostachis at 100mg/mL MIC showed the highest mean zone of inhibition (20.2 ± 1.48) on E. coli while Prunes Africana at 50mg/mL MIC showed 12.9 ± 0.74. The highest mean zone of inhibition 13.8 ± 0.84 for Datura Stamonium at a MIC of 100mg/mL and lowest mean zone of inhibition 11.64 ± 0.86 for Crotona macrostachis at 100mg/mL MIC was observed on S. aureus. Moreover, compared to S. aureus, better efficacy was observed for all tested plant extracts against E. coli.
Conclusion
This study indicated that traditional medicinal plant preparations might be considered as an alternative option for the treatment of resistant isolates of clinical bovine mastitis.
Digital economy and high-quality development of manufacturing industry in China：Based on technology innovation effect and management efficiency
Authors: Yang Yi , Yu Qian
Published: March 2023

The digitalization process of China's manufacturing industry has entered a critical period, and the real economy is also in an important period of high-quality development. Promoting the organic integration of manufacturing industry and digital economy to achieve high-quality development is a key and difficult problem to be solved. This paper examines the impact of digital economy on the high-quality development of manufacturing industry, the action mechanism and possible regional heterogeneity of the influence based on a panel dataset of 31 Chinese provinces and cities. The results show that digital economy can significantly promote the high-quality development of manufacturing industry, technological innovation and management efficiency have played positive intermediary roles in the relationship, furthermore,the technological innovation has a greater intermediary effect. There is regional heterogeneity about this impact, for example, the promotion effect in the eastern, western and southern regions is more significant than that in the center and north. At the time when China’s economic growth is transforming the old and new kinetic energy, more attention should be paid to the construction of infrastructure related to the development of digital economy, to promote the development of digital economy according to local conditions, to cultivate innovation platforms, to strengthen the training of digital technology talents, to promote digital industrialization and industrial digitalization, and to achieve high‐quality development of the manufacturing industry.
VR-Herbarium Application: The Case of KATO Herbarium in Karadeniz Technical University
Authors: Akın Alper Tunga , Ünver Saliha , Alkiş Kamber Can
Published: March 2023

It requires a significant amount of time, money and effort to visit institutions containing different collections in different parts of the world, for many reasons such as transportation, visa, and research permit. In this study, it is aimed to develop a virtual herbarium with both mobile and browser support, which will enable to access the panoramic view of the herbarium and the visual and botanical characteristics of the herb samples in the herbarium. Karadeniz Technical University Faculty of Forestry (KATO) Herbarium, established in 1973 and registered in the International Herbarium Index, was chosen as the study area. The virtual herbarium (VR) KATO application was carried out in three stages: production of panorama images of the herbarium, creation-connection of the database and programming of the application. Within the scope of the study, a database containing the botanical features and images of 20 herb samples in the herbarium was also created using the MongoDB Atlas connection, and a dynamically-updatable herb library was presented to the online visitors. This study is a pioneer with the concept of virtual reality and a distinctive example of mixed reality technologies’ usage in the forestry discipline. Besides that, the study is a unique example for different fields related to forestry, which contains different libraries such as flora, fauna, endemic species, and national parks, and for other sectors.
The Structural and Electrical properties of Guar Gum based Green Electrolyte
Authors: SRINI BOLLABATHINI , Sreek T. , Rajesh S.
Published: March 2023

Guar gum is an environmental tree-based natural polymer with a large molecular weight. Guar gum polymer electrolytes are new materials that are being developed for the applications of electrochemical devices such as supercapacitors, high energy density batteries, fuel cells, electrochromic displays, etc. The solution casting method has been employed to prepare solid-state composite Green-polymer electrolytes using Guar gum, Zinc Sulphate heptahydrate salt (ZnSO4.7H2O). These synthesized polymer electrolytes have been studied by using X-Ray Diffraction(XRD), Fourier Transformation Infrared (FTIR), Differential scanning calorimetry (DSC), Scanning Electron Microscope(SEM), and Electrical impedance Spectroscopy(ESI) techniques. The addition of the zinc (ZnSO4.7H2O) salt, to withstand the ion movement in composite guar gum matrix electrolyte was the main investigation in the present work. The complexation of polymer and salt was confirmed by the FTIR. The phase transition and amorphous nature were confirmed by X-Ray Diffraction (XRD). The glass transition temperature was calculated for all samples by using a DSC study. The scanning electron microscopy(SEM) technique investigated that the surface exhibited anisometric morphology (spherical and elongated)for pure guar gum and while in the composite polymer, bounded the salt ion within the guar gum matrix. The ionic conductivity was calculated using bulk resistance at room and different temperatures. The maximum ionic conductivity is 2.5x10− 5 S/cm at 100oC for a pure guar gum sample, while with the addition of the salt guar gum, a non-linear variation of the conductivity was found. The long tail in dielectric constant(εʹ(ω)) and loss (εʺ(ω) analysis was refect the bulk capacitance nature of the sample. The non-Deby behavior and relaxation process was studied by dielectric modulus parameters.
Seizure-like Symptoms Induced by Hypomagnesemia in a Patient with Incomplete Small Bowel Obstruction: A Case Report and Literature Review
Authors: Zhu Mingjin , Chen Wenjun , Weng Jiyan
Published: March 2023

Background
Seizure-like symptoms are rare in older patients without brain damage. Small bowel obstruction is a common clinical disorder for older patients that can cause electrolyte disturbances and nutritional disorders. Hypomagnesemia is a frequently overlooked electrolyte disorder. Moreover, magnesium deficiency can lead to severe seizure-like symptoms.
Case presentations:
An 85-year-old man was admitted to the hospital with weakness and slow movement. Shortly after hospitalization, he experienced incomplete small bowel obstruction; thus, parenteral nutrition and intravenous esomeprazole were administered. When intestinal obstruction was relieved, the patient suddenly experienced seizure-like symptoms three times, and 24-h electroencephalogram did not capture any epileptiform pattern. After excluding other causes, we considered serum magnesium deficiency as a diagnosis. Low serum magnesium levels were related to a shortage of absorption due to small bowel obstruction, excess excretion of renal dysfunction, and the use of proton pump inhibitor. However, the exact mechanism underlying the hypomagnesemia-induced seizure-like activity remained unclear. After adjusting the nutritional support and magnesium supplementtion, the patient’s serum magnesium level returned to normal and he was free of seizure-like activity.
Conclusion
Hypomagnesemia is often asymptomatic, but it can lead to severe seizure-like symptoms. It is important to pay attention to the serum magnesium level and nutritional intake in patients with an incomplete small bowel obstruction.
Exploring the Dynamics of Providing Cognition Using a Computational Model of Cognitive Insomnia
Authors: Rateb Roqia , Thalji Nisrean , shorman Amal , shorman Areej
Published: March 2023

Insomnia is a common sleep-related neuropsychological disorder that can lead to a range of problems, including cognitive deficits, emotional distress, negative thoughts, and a sense of insufficient sleep. Insomnia can also worsen or lead to other medical conditions. Despite the existence of various insomnia-related cognitive models, clinical studies, and guidelines, there appears to be a lack of an evidence-based dynamic model for a personalized approach to treating insomnia .This study proposes a providing computational dynamic cognitive model (PCDCM) insight into providing cognitive mechanisms of insomnia and consequent cognitive deficits. Since the support providing is significantly dynamic and it includes substantial changes as demanding condition happen. From this perspective the underlying model covers integrating of both coping strategies, provision preferences and adaptation concepts. The model was found to produce realistic behavior that could clarify conditions for providing support to handle insomnia individuals, which was done by employing simulation experiments under various negative events, personality resources, altruistic attitude and personality attributes. Simulation results show that, a person with bonadaptation and either problem focused or emotion focused coping can provide different social support based on his personality resources, personality attributes, and knowledge level, whereas a person with maladaptation regardless the coping strategies cannot provide any type of social support. Moreover, person with close tie tends to provide instrumental, emotional, and companionship support than from weak tie. These results were similar to those with the model’s mathematical analysis. Finally, a mathematical analysis was used to examine the possible equilibria of the model.
Research on Urban Water Security Based on Water Poverty Theory - A Case Study of Lower Yellow River Cities
Authors: Tian Yueru , Hua Chunyu , Zhu Mengyuan , Fang Zhaotong , Yong Xian , Yang Jiaying , Fang Shumin , Ren Lijun
Published: March 2023

An vital guarantee for human existence is the availability of water resources. Rapid urbanization has increased the need for additional urban water resources, which has constrained sustainable urban and regional advancement. We evaluated the spatial and temporal changes in the water poverty index for the locality, looked at the relationships between the evaluation system's indicators, and investigated the main barriers to improving water security using all prefectural cities in Shandong Province as the study subjects.The findings reveal that (1) From 2000 to 2020, Shandong Province's water poverty index at all levels showed an upward trend, the province's overall water security status greatly improved, and the five subsystem values in the WPI system as a whole climbed dramatically. (2) The density of water supply pipes is strongly positively correlated with the proportion of landscaped areas. The rate of centralized sewage treatment is strongly inversely correlated with the water usage of GDP of 10,000 Yuan and industrial value added of 10,000 Yuan. (3) The low percentage of ecological water usage is the primary barrier preventing WPI improvement, according to calculations using the barrier level model. In addition, the high water consumption of GDP of 10,000 Yuan and industrial value added of 10,000 Yuan are factors affecting urban water security. The area should work to increase the rates at which its water resources are utilized, particularly the ratio at which industrial water is used repeatedly. It ought to give ecological water compensation greater consideration and utilize more ecological water overall.
Impact of KIF6 Trp719Arg gene variant on Coronary Artery Disease Development
Authors: eldesouky mohamed , Abd-Elazim Amina , Elhakim Heba , Fayed Hany
Published: March 2023

Coronary artery disease (CAD) is a multifactorial disease resulting from the interaction of genetic varia-tion and environmental traditional risk factors (TRFs), including diabetes mellitus, smoking, dyslipidemia, and hypertension. KIF6 Trp719Arg (rs20455; A>G) is an interesting gene variant reported as one of the most important risk factors for CAD in different populations. The study enrolled 150 participants belong-ing to the National Heart Institute (NHI) catheterization unit in Egypt, who were grouped into three main study groups regarding the presence of different TRFs. Biochemical investigations and clinical data were assessed and recorded. Analysis for KIF6 Trp719Arg polymorphism (rs20455; A>G) was performed for all participants using the TaqMan genotyping real-time PCR assay (rs20455). The study demonstrated that diabetes mellitus, hypertension, dyslipidemia, and smoking were highly statistically significant among CAD with TRF and non-CAD with TRF patients with p-values of 0.009*, 0.003*, 0.046*, and 0.001**, re-spectively. The family history of premature CAD represents a high percentage of CAD without TRF pa-tients compared to the other groups with a statistical difference of p-value= 0.004*. A high prevalence of AG+GG genotypes among the different groups was obtained, representing 66.0% of CAD with TRF, 76.0% of CAD without TRF, and 60% of non-CAD with TRF patients. The present study elucidated the impact of KIF6 Trp719Arg as a dependent risk factor for CAD, as it could have a significant role in CAD develop-ment when it interacts with one or more of the other traditional risk factors.
A high figure of merit of phonon-polariton waveguide modes with hBN/SiO 2 /graphene/hBN ribs waveguide in THz range
Authors: 刘 悦 , ZHAO YUE , JIN GAO , ZHANG QIANG , FU SHUFANG , WANG XIANGGUANG , WANG XUAN , WANG XUANZHANG , ZHOU SHENG
Published: March 2023

The utilization of THz waveguides has enabled a variety of applications in integrated optics and communications. To effectively control THz signals on photonic chips, it is essential to design a waveguide that offers both a high figure of merit (FOM) and low loss. In this paper, we propose a THz waveguide composed of a dielectric rib and a graphene layer sandwiched between two hexagonal boron nitride (hBN) ribs on a gold layer. Numerical simulations demonstrate the existence of two type guided modes of the proposed waveguide in the second reststrahlen band (1360.0cm− 1 < ω < 1609.8cm− 1) of hBN. These modes are formed by coupling the hyperbolic phonon polariton (HPhP) of two hBN rib in the middle dielectric rib and are then modulated by a graphene layer. Interestingly, we found that four waveguide transmission parameters, including an effective length, a figure of merit, a device length and a propagation loss of the guided modes, vary with operation frequency and gate voltage. By altering geometry parameters and dielectric permittivity, the modal properties were analyzed. Simulation results demonstrate that a high FOM of 4.0×107 is achieved by optimizing waveguide size parameters. The proposed waveguide offers a promising approach for designing a tunable THz waveguide on photonic chips, which can be extended to other hyperbolic materials and 2D materials such as MnO3, silicone and germanene.
Predicting human risk with multidrug resistant Enterobacter hormaechei MS2 with MCR 9 gene isolated from the feces of healthy broiler through whole genome sequence based analysis.
Authors: S Sreejith , Premnath Manjusha , PR Prathuish , Mathew Jyothis , Abraham Swapna Susan , Nath Chitra C , Paul Nimmy , EK Radhakrishnan
Published: March 2023

The zoonotic spread of antimicrobial resistance (AMR) and the associated infections are becoming a major threat to the human population worldwide. Strategies to identify the potential pathogen dissemination by seemingly healthy livestock are at a nascent stage and it is of significant importance to monitor environmental evolution of AMR. In this study, a multidrug resistant strain of Enterobacter hormaechei MS2 isolated from the feces of healthy broiler chicken has been characterized by whole genome sequencing based method. Here, the isolate was primarily subjected to antimicrobial susceptibility testing followed genome sequencing and analysis. From the antimicrobial susceptibility testing result, the strain was found to be resistant to multiple classes of drugs including the colistin which is an important candidate drug used to treat infectious diseases. The resistome prediction of genomic data further revealed the presence of 7 perfect and 26 strict hits including those for MCR-9 and FosA6. The pathogenicity prediction has also demonstrated the strain to have the potential to be a human pathogen with 0.72 probability. The phylogenetic analysis has also supported the zoonotic potential of the strain due to its clustering with isolates from both human and livestock-associated host groups. The results of the study suggest the need for a strong surveillance system to identify the opportunistic zoonotic pathogens to prevent a silent AMR menace mediated by them. Carriage of multi-drug resistant strains in the livestock gut microbiome is also a serious concern as it has high AMR transmissibility through contact and supply chain activities.
BRISE-Plandok: a German legal corpus of building regulations
Authors: Recski Gábor , Iklódi Eszter , Lellmann Björn , Kovács Ádám , Hanbury Allan
Published: March 2023

We present the BRISE-Plandok corpus, a collection of 250 text documents with over 7,000 sentences from the Zoning Map of the City of Vienna, annotated manually with formal representations of the rules they convey. The generic rule format used by the corpus enables automated compliance checking of building plans, a process developed as part of the BRISE project. The format also allows for conversion to multiple logic formalisms, including dyadic deontic logic, enabling automated reasoning. Annotation guidelines were developed in collaboration with experts of the city's building inspection office, describing nearly 100 domain-specific attributes with examples. Each document was annotated independently by two trained annotators and subsequently reviewed by the authors. A rule-based system for the automatic extraction of rules from text was developed and used in the annotation process to provide suggestions. The reviewed dataset was also used to train a set of baseline machine learning models for the task of attribute extraction, the main step in the rule extraction process. Both the rule-based system and the ML baselines are evaluated on the annotated dataset and released as open-source software. We also describe and release the framework used for generating and parsing the interactive xlsx spreadsheets used by annotators.
Operational Groups of the NKGB and a Reconstruction of the Soviet Security Apparatus in Axis Occupied Ukraine, 1943–44
Authors: Melnyk Oleksandr
Published: March 2023

This article elucidates the reconstruction of the Soviet security apparatus during World War II in what today is western Ukraine. In late 1943 to early 1944, six operational groups of the People’s Commissariat of State Security of the Ukrainian Soviet Socialist Republic headed to the Axis occupied territories with orders to re-establish contacts with Soviet secret agents and create a support infrastructure for the deployment of other operational groups, special purposes units, and individual agents, as well as to infiltrate organizations of Polish and Ukrainian nationalists. The essay examines Soviet special operations within the context of state efforts to project power into the Axis occupied territories. It sheds light on the objectives of Soviet security agencies and on the activities of individual units in the field.
A Short History of the Ukrainian Canadian Research and Documentation Centre on the Fortieth Anniversary of Its Founding
Authors: Stech Zorian
Published: March 2023

This essay examines the history of the Ukrainian Canadian Research and Documentation Centre (UCRDC) in Toronto, looking at how the tragedy of the Holodomor led Ukrainian-Canadians to come together in speaking out against the Soviet regime and equally, reaffirming Ukrainian nationality on the world stage. It also examines how the UCRDC evolved from mainly studying the Holodomor to exploring other topics of interest to Ukrainians worldwide. Through filmmaking, archival development, and publications, the UCRDC has worked in ensuring that the voices of Ukraine and Ukrainians be heard.
Populismus und Kompetenz
Authors: Gemkow Johannes
Published: March 2023

Dieser Beitrag stellt eine theoretische Konzeption praxeologischer Populismusforschung vor. Die praxeologische Populismusforschung ist in der Medienpädagogik bisher noch nicht diskutiert worden. Zwar haben praxeologische Ansätze in der Medienpädagogik bereits ihre eigene Praxis geschaffen. Die Zugänge reichen von Mikro-Themen wie Coding (Verständig 2020) oder Online-Rollenspiele (Raudonat und Marsden 2020) bis hin zu metatheoretischen Reflexionen (Bettinger 2018; Bettinger und Hugger 2020). Der Themenbereich Populismus ist bisher jedoch noch nicht in diesen Kontexten in Erscheinung getreten. Auf dem Weg zu einer Konzeption praxeologischer Populismusforschung wird in diesem Beitrag zuerst dessen Bedeutung für die aktuelle Populismusforschung aufgezeigt. Dazu werden zentrale Ergebnisse und Forschungsansätze der Populismusforschung skizziert und diskutiert. Zweitens wird die Rolle von Social Media als unterstützender Raum für populistische Kommunikationspraktiken erörtert. Drittens wird schliesslich ein Forschungsansatz für eine praxeologische Populismusforschung vorgestellt und dessen Bedeutung für die medienpädagogische Kompetenzforschung reflektiert. Der Beitrag versteht sich als rein theoretisch-zeitdiagnostisch. Das übergreifende Ziel ist es, eine Debatte aufzuschlagen, in der die medienpädagogische Forschung pragmatisch eine Antwort auf ihre gestiegene Bedeutung für den gesellschaftlichen Zusammenhalt liefert.
Rezeption muslimischer Repräsentationen und gesellschaftlicher Zusammenhalt
Authors: Niemand Stephan
Published: March 2023

Im Artikel werden Befunde einer qualitativen Rezeptionsstudie mit Angehörigen der muslimischen Diaspora zu Medienrepräsentationen des Islams präsentiert. Ausgangspunkt für die Durchführung der Studie waren zwei zentrale Aspekte. Erstens belegen zahlreiche Inhaltsanalysen, dass über Muslimas und Muslime sowie den Islam zumeist ereigniszentriert und in einem gewalt- und konfliktbehafteten Kontext berichtet wird. Es ist anzunehmen, dass eine derart negativ verengte Berichterstattung nicht folgenlos für den Zusammenhalt in der Gesellschaft bleibt. Allerdings ist zweitens wenig darüber bekannt, wie Muslimas und Muslime selbst die Islamberichterstattung wahrnehmen und ob sie muslimische Medienbilder als Gefährdung für den gesellschaftlichen Zusammenhalt deuten. Diese Leerstelle aufgreifend wurden 12 problemzentrierte Leitfadeninterviews mit Angehörigen der muslimischen Diaspora geführt. Die Befunde zeigen, dass aus Sicht der Interviewten die mediale Repräsentation weitestgehend nicht mit ihrem eigenen Selbstverständnis übereinstimmt und nur wenig Identifikationspotenzial bietet. Im Gegenteil, sie fühlen sich vielfach durch die Islamberichterstattung diskriminiert und ausgegrenzt. In diesem Zusammenhang werden Tendenzen einer Gefährdung des gesellschaftlichen Zusammenhalts sichtbar. Für die medienpädagogische Praxis bieten die empirischen Befunde zahlreiche Ansatzpunkte.
Mixed Methods im Kontext gestaltungsorientierter Bildungsforschung
Authors: Seyferth-Zapf Christian
Published: March 2023

Der vorliegende Beitrag befasst sich mit der Anwendung von Mixed Methods im Kontext gestaltungsorientierter Bildungsforschung. Hierfür werden zunächst grundlegende Charakteristika, Motive und Designformen von Mixed Methods erarbeitet, bevor anschließend verschiedene Möglichkeiten der Integration vorgestellt werden. Daraufhin folgt eine Untersuchung exemplarisch ausgewählte Ansätze gestaltungsorientierter Bildungsforschung hinsichtlich der systematischen Kombination qualitativer und quantitativer Methoden. Anhand eines Forschungsprojekts zur Förderung von Medienkritikfähigkeit bei Jugendlichen im Kontext zeitgenössischer Propaganda, das auf Basis der praxis- und theorienorientierten Entwicklung und Evaluation von Konzepten unterrichtlichen Handelns (vgl. Tulodziecki, Grafe, und Herzig 2013) entwickelt wurde, soll schlussendlich die konkrete Umsetzung von Mixed-Methods-Designs sowie die Verwendung von Integrationsstrategien demonstriert werden.
In den Kopf und unter die Haut
Authors: Beiler Markus , Biskop Robert Benjamin , Damerau Frederik , Krüger Uwe , Lücker Markus , Pfeiffer Juliane , Pollak Christopher
Published: March 2023

Die Skepsis gegenüber der Demokratie und ihren Institutionen sowie gegenüber den etablierten Medien ist im Freistaat Sachsen besonders gross. Um diesem Problem zu begegnen, ist das Zentrum Journalismus und Demokratie der Universität Leipzig (JoDem) gemeinsam mit dem Zentrum für Lehrer:innenbildung und Schulforschung seit 2020 verstärkt in der Lehramtsausbildung aktiv, um den angehenden Multiplikator:innen der sächsischen Schulen Journalismus- und Demokratiekompetenz zu vermitteln. In diesem Beitrag werden Einblicke in die Konzeption und den Erfolg der Lehrveranstaltungen gegeben. In den Seminaren wird auf eine konsequente Verschränkung von theoretischem Wissen mit praktischem Tun und Erleben gesetzt, etwa mit der Produktion von realen Zeitungsseiten, Radiobeiträgen und Social-Media-Inhalten oder mit dem Einbezug von Elementen des erfahrungsorientierten Demokratietrainings «Betzavta» aus Israel.
Digital Streetwork
Authors: Wiedel Fabian
Published: March 2023

Der kommunikationswissenschaftlich gerahmte Beitrag definiert zunächst zentrale Chancen und Risikofelder mediatisierter Gesellschaftskommunikation. Eine aktive Medienpädagogik wird vor diesem Hintergrund als wichtiger Faktor vor allem unter Heranwachsenden etabliert. Die praktische Medienkompetenzvermittlung muss sich momentan allerdings substanziellen Herausforderungen stellen: Gerade Lehrpersonen und Eltern verfügen in der Breite nicht über ausreichende Kenntnisse, Ressourcen und Handlungsmotivationen. Eine vergleichsweise grosse medienpädagogische Last liegt deshalb im rehabilitativen Bereich, wenn also bereits (nachhaltig) negative Nutzungserfahrungen konstruktiv verarbeitet werden müssen. Verantwortlich für diese Unwucht ist auch, dass Medienpädagog:innen derzeit nicht auf das eigentliche Digitalhandeln Heranwachsender zugreifen können. Diese schliessen ihre virtuellen Rückzugsorte auch bewusst gegenüber Erwachsenen ab. Vorgeschlagen wird deshalb, die Methoden analoger Strassensozialarbeit in den digitalen Raum zu übertragen und medienpädagogisch einzusetzen. Speziell für digitale Netzwerke und Communitys ausgebildete Streetworker:innen könnten nutzungsbegleitend und über einen längeren Zeitraum mit Kindern und Jugendlichen arbeiten. Die medienpädagogische Wirksamkeit könnte dadurch ansteigen, auch weil von innen heraus der tatsächliche Bedarf definiert und die optimale Unterstützung aktiviert werden kann. Digital Streetwork könnte insofern zu einem koordinierenden Schlüsselmoment im gesellschaftlichen Netzwerk medienpädagogischer Akteur:innen werden. Empirisch überprüft wurde der Ansatz hier am Anwendungsbeispiel Videospielsucht in einer Leitfaden-Befragung von 20 Expert:innen aus der praktischen Medienpädagogik und Sozialarbeit, aus Psychologie und Psychiatrie sowie aus dem Gaming.
Co-Creation von Apps für den Lokaljournalismus
Authors: Hoch Hendrik , Roeske Adrian
Published: March 2023

In Zeiten tiefgreifender Mediatisierung konkurrieren Medienproduzent:innen zunehmend um die Aufmerksamkeit von Nutzenden, was insbesondere für den Lokaljournalismus Herausforderungen mit sich bringt. Im Projekt «Tinder die Stadt» ist mit Co-Creation ein Ansatz gewählt worden, der sowohl als Methode als auch Haltung verstanden werden kann. Der vorliegende Beitrag diskutiert einerseits die Herausforderungen, mit denen (Lokal-)Journalismus konfrontiert ist, und führt Co-Creation als partizipative Methode ein. Diese ist herangezogen worden, um den digitalen Prototypen einer lokalen Nachrichtenapp zu entwickeln. Gleichzeitig werden Berührungspunkte zwischen partizipativer Forschung und (medien)pädagogischen Ansätzen aufgezeigt. Die Auseinandersetzung ist in die Kontexte Co-Creation und gesellschaftlicher Zusammenhalt eingebettet. Partizipation wird hierfür an unterschiedlichen Stellen als Baustein diskutiert, um gesellschaftliche Herausforderungen zu adressieren. Gleichzeitig unterliegt das Einbeziehen unterschiedlicher Teile der Gesellschaft verschiedenen Mechanismen und ist mit bestimmten Effekten konfrontiert, die es zu berücksichtigen gilt. Der Beitrag versucht somit aufzuzeigen, wie Lokaljournalismus dazu beitragen kann, Gesellschaft durch die Darstellung und Präsentation unterschiedlicher Inhalte auf lokaler Ebene zusammenzuhalten.
Topological quantum phase transition of nickelocene on Cu(100)
Authors: Blesio Germán G. , Žitko Rok , Manuel Luis O. , Aligia Armando A.
Published: March 2023

Local quantum phase transitions driven by Kondo correlations have
been theoretically proposed in several magnetic nanosystems; however,
clear experimental signatures are scant. Modeling a nickelocene molecule
on a Cu(100) substrate as a two-orbital Anderson impurity with
single-ion anisotropy coupled to two conduction bands, we find that
recent scanning tunneling spectra reveal the existence of a topological
quantum phase transition from the usual local Fermi liquid with high
zero-bias conductance to a non-Landau Fermi liquid, characterized by a
non-trivial quantized Luttinger integral, with a small conductance. The
effects of intermediate valence, finite temperature, and structural
relaxation of the molecule position allow us to explain the different
observed behaviors.
Marketing Kit bagi UMKM
Authors:   Politeknik Piksi Ganesha, Jl. Gatot Subroto No.301, Maleer, Kec. Batununggal, Kota Bandung, Jawa Barat 40274, Indonesia, Yusuf Ramayani , Veranita Mira ,   Universitas Pendidikan Indonesia, Jl. Dr. Setiabudi No.229, Isola, Kec. Sukasari, Kota Bandung, Jawa Barat 40154, Indonesia, Syahidin Yuda ,   Universitas Pasundan, Jl. Tamansari No.6-8, Tamansari, Kec. Bandung Wetan, Kota Bandung, Jawa Barat 40116, Indonesia, Hernawati Euis ,   Institut Teknologi Bandung, Jl. Ganesa No.10, Lb. Siliwangi, Kecamatan Coblong, Kota Bandung, Jawa Barat 40132, Indonesia
Published: March 2023

The impact of social media in assessing a product's brand strength can no longer be ignored. The purpose of this paper is to describe Sorai Steamboat n Grill's community service efforts. To make it easier for MSMEs to advertise their products, marketing kits in the shape of logos, business cards, posters, and other promotional media are created. A marketing kit is an effective instrument for initiating product promotion operations. The requirements research, planning, creation of marketing kits, and mentoring of MSMEs are all part of the community service stage.The marketing kit was created without a hitch owing to the proprietor of Sorai Steamboat n Grill's helpful cooperation. The number of Instagram followers grew, the brand was strengthened, and revenue increased as a result of this action.
Manfaat Aktivasi Digitalisasi pada Pendapatan UMKM
Authors:   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Christina Christina , Ravindra Putra Claudio ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Steven Leonardo ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Aruan Michelle ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Joab Jonathan ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Novianti Debby ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Desia Wirini ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Wangsa Rivaldo ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Rinaningsih Rinaningsih ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia
Published: March 2023

MSMEs have the potential to achieve economic growth, even distribution and labor income, create jobs, and overcome poverty in Indonesia. Therefore, it is necessary to empower and develop the potential of MSMEs whose perpetrators are recorded to reach 64.2 million and contribute more than half of the gross domestic product in 2021 through the PKM program. One of the biggest obstacles for MSME perpetrator is marketing their products by utilizing digital marketing which has a big impact as the times move towards modernity. So that education is needed on the use of appropriate media to market products from MSME perpetrator. From January to June 2022, in-depth interviews were conducted, it can be seen how much knowledge about digital marketing and based on the results of the interview, appropriate materials are made so that perpetrator can take advantage of technology and can independently develop their businesses. It turns out, perpetrator don't know much about digital marketing, so education is needed, from planning to execution. Through the provision of materials, partners can use social media as a platform to do digital marketing independently and their business can grow rapidly.
Vision-based texture and color analysis of waterbody images using computer vision and deep learning techniques
Authors: Erfani Seyed Mohammad Hassan , Goharian Erfan
Published: March 2023

Vision-based analysis of waterbodies can provide important information required for monitoring, analyzing, and managing water resource systems, such as visual flood detection, delineation, and mapping. Water, however, is an ornery object in image processing, as it can be found in different forms and colors in nature. This makes the detection, classification, and tracking of water in images and videos difficult for computer vision models. There are still visual differences resulting from water texture and its inherent optical properties associated with different waterbodies which can be recognized and extracted to support computer models to better analyze water images. This study aims to utilize a set of early, mid-level, and high-level vision techniques, including Gabor kernels, local binary patterns (LBPs), and deep learning (DL) models to extract and analyze water texture and color of different waterbodies in digital images. For this purpose, ATLANTIS TeXture (ATeX), an image dataset for waterbodies classification and texture analysis, was used. Models were trained for the task of classification on ATeX. Then, the performance of each model in extracting texture features was evaluated and compared. Results showed that the classification accuracy achieved by the Gabor magnitude tensor, LBP, and DL model (ShuffleNet V2 × 1.0) are 29, 35, and 92%, respectively, and thus the DL model outperforms traditional vision-based techniques. Moreover, the classification results on raw images represented by different color spaces (e.g., RGB, HSV, etc.) emphasized the importance of color information for digital image processing of water. Analyzing representative visual features and properties of different water types and waterbodies can facilitate designing a customized Convolutional Neural Networks (CNNs) for water scenes, as CNNs recognize objects through the analysis of both texture and shape clues and their relationship in the entire field of view.
Estimation of water's surface elevation in compound channels with converging and diverging floodplains using soft computing techniques
Authors: Bijanvand Sajad , Mohammadi Mirali , Parsaie Abbas
Published: March 2023

In this research, water's surface elevation in compound channels with converging and diverging floodplains using soft computing models including the Multi-Layer Perceptron Neural Network (MLPNN), Group Method of Data Handling (GMDH), Neuro-Fuzzy Group Method of Data Handling (NF-GMDH) and Support Vector Machine (SVM) was modeled and predicted. For this purpose, laboratory data published in this field were used. Parameters including convergence angle (with a positive sign) and divergence angle (with a negative sign), relative depth, and relative distance were used as input variables. The results showed that all the used models have appropriate performance. However, the best performance was related to the SVM model with statistical indicators R2 = 0.998 and RMSE = 0.008 in the testing stage. The use of the adaptive fuzzy approach in developing the GMDH model led to a remarkable increase in accuracy so that its statistical indicators in the testing stage reached R2 = 0.985 and RMSE = 0.203. It was found that the best performance of the activation and kernel functions in the development of the MLPNN model and the SVM is related to the sigmoid and radial tangent functions.
An n-valued neutrosophic set method for the assessment of an offshore oil spill risk
Authors: Han Minglei , Fan Changxing , Huang Shan , Hu Keli , Fan En
Published: March 2023

With the development of maritime transportation, oil spill accidents occur frequently. In this paper, a scientific and reasonable assessment of ship oil spills, offshore oil platform oil spills, and subsea pipeline oil spills is carried out, and a risk assessment method of an offshore oil spill based on an n-value neutrosophic set is proposed. First, the oil spill risk evaluation index systems of these three risk sources are constructed, respectively, and the entropy weight method is used to calculate the weight. Second, we establish a risk assessment model under the n-value neutrosophic environment. Furthermore, we use the n-value neutrosophic-weighted arithmetic average (NVNWAA) to calculate the risk levels of the following three risk sources: ship oil spills, offshore oil platform spills, and submarine pipeline spills. Finally, according to the results of the risk assessment, the countermeasures to strengthen the preventive measures of oil spill accidents are put forward.
The Effect of Retroconversion Metabolism of N-oxide Metabolites by Intestinal Microflora
on Piperaquine Elimination in Mice, as well as in Humans Predicted Using a
PBPK Model
Authors: Xing Jie , Zhou Hongchang , Zhang Liyuan , Ji Jianbo , Xie Yuewu
Published: March 2023

Background:

Piperaquine (PQ) and its pharmacologically active metabolite PQ N-oxide (PM1) can be
metabolically interconverted via hepatic cytochrome P450 and FMO enzymes.

Objectives:

The reductive metabolism of PM1 and its further N-oxidation metabolite (PM2) by intestinal microflora
was evaluated, and its role in PQ elimination was also investigated.

Methods:

The hepatic and microbial reduction metabolism of PM1 and PM2 was studied in vitro. The reaction phenotyping
experiments were performed using correlation analysis, selective chemical inhibition, and human recombinant
CYP/FMO enzymes. The role of microbial reduction metabolism in PQ elimination was evaluated in mice pretreated
with antibiotics. The effect of the reduction metabolism on PQ exposures in humans was predicted using a
physiologically-based pharmacokinetic (PBPK) model.

Results:

Both hepatic P450/FMOs enzymes and microbial nitroreductases (NTRs) contributed to the reduction metabolism
of two PQ N-oxide metabolites. In vitro physiologic and enzyme kinetic studies of both N-oxides showed a
comparable intrinsic clearance by the liver and intestinal microflora. Pretreatment with antibiotics did not lead to a
significant (P > 0.05) change in PQ pharmacokinetics in mice after an oral dose. The predicted pharmacokinetic
profiles of PQ in humans did not show an effect of metabolic recycling.

Conclusions:

Microbial NTRs and hepatic P450/FMO enzymes contributed to the reduction metabolism of PQ Noxide
metabolites. The reduction metabolism by intestinal microflora did not affect PQ clearance, and the medical
warning in patients with NTRs-related disease (e.g., hyperlipidemia) will not be clinically meaningful.
Design, Synthesis and Anticancer Evaluation of New 1-allyl-4-oxo-6-(3,4,5-
trimethoxyphenyl)-1,4-dihydropyrimidine-5-carbonitrile Bearing Pyrazole
Moieties
Authors: Osman Nermine A. , EL-Sayed Nermine S. , Abdel Fattah Hanan A. , Almalki Ahmad J. , Kammoun Ahmed K. , Ibrahim Tarek S. , Alharbi Abdulrahman S. , AL-Mahmoudy Amany M.
Published: March 2023

Aim:

pyrimidine and pyrazole have various biological and pharmaceutical applications
such as antibacterial, antifungal, antileishmanial, anti-inflammatory, antitumor, and anti-cancer.

Introduction:

In this search, the goal is to prepare pyrimidine-pyrazoles and study their anticancer
activity.

Methods:

1-allyl-4-oxo-6-(3,4,5-trimethoxyphenyl)-1,4-dihydropyrimidine-5-carbonitrile bearing pyrazoles (4,6-8) have been synthesized. Firstly, the reaction of 1-allyl-2-(methylthio)-4-oxo-6-(3,4,5-trimethoxyphenyl)-1,4-dihydropyrimidine-5-carbonitrile (1) with chalcones 2a-b produced the intermediates 3a-b. The latter was reacted with hydrazine hydrate to give the targets 4a-b. On the other hand, hydrazinolysis of compound 1 yielded the hydrazino derivative 5 which upon reac-tion with chalcones 2c-i or 1,3-bicarbonyl compounds afforded the compounds 6-8. Finally, the new compounds were characterized by spectral data (IR, 1H NMR, 13C NMR) and elemental analysis. Moreover, they were evaluated for Panc-1, MCF-7, HT-29, A-549, and HPDE cell lines as anti-cancer activity.

Results:

All the tested compounds 3,4,6-8 showed IC50 values > 50 μg/mL against the HPDE cell line. Compounds 6a and 6e exhibited potent anticancer activity where the IC50 values in the range of 1.7-1.9, 1.4-182, 1.75-1.8, and 1.5-1.9 μg/mL against Panc-1, MCF-7, HT-29, and A-549 cell lines.

Conclusion:

New pyrimidine-pyrazole derivatives were simply synthesized, in addition, some of them showed potential anticancer activity.
Current Strategies of New Drugs for Diabetes Management
Authors: Sarfraz Maliha , Hafizur Rahman M. , Ullah Hayat , Sajid Sanaullah , Akhtar Rana Waseem , Noreen Mamoona , Perveen Shazia , Khan Misbah Ullah
Published: March 2023

Several aspects need to be explored in drug therapy for diabetes patients.
Some specific glucose-reducing medicines are present, while other medicines are
associated with unintentional changes in hyperglycemia. Diabetes is a developing
epidemic that has caused significant socioeconomic problems in several countries
throughout the world. Despite scientific discoveries, greater healthcare services, and
higher literacy rates, the disease continues to plague many industries, particularly
developing countries. The current trends show an increase in premature mortality,
which threatens world prosperity. Experimental and technical improvements have been
made in sulphonylureas, alpha-glucosidase inhibitors, biguanides, and
thiazolidinediones, all of which are beneficial in lowering glucose levels. The latest
drug research techniques have led to the development of novel therapeutic groups such
as amylin analogs, incretin mimetics, GIP analogs, active peroxisome proliferator
receptors, and dipeptidyl peptidase-4 inhibitors as targets for future diabetes therapy
medications. Furthermore, drug development and detection for diabetes treatment have
been revolutionized by identifying and investigating bioactive compounds from herbs.
This chapter discusses vital fields of clinical diabetology regarding opportunities for
stem cells and nanotechnology as next-generation therapies, with an emphasis on
evolving developments and reviews why plant-derived products are reliably common
for treating and managing diabetes.