bluuebunny/crossref_metadata_2025 huggingface dataset:
The Use of Low-Cost Unmanned Aerial Vehicles in the Process of Building Models for Cultural Tourism, 3D Web and Augmented/Mixed Reality Applications
Authors: Templin Tomasz , Popielarczyk Dariusz
Published: September 2020

Unmanned Aerial Systems (UAS) are widely used in low-cost photogrammetry. Even small Unmanned Aerial Vehicles (UAV) can deliver valuable data for the inventory of inaccessible and dangerous areas or objects. The acquisition of data for 3D object modeling is a complicated, time-consuming, and cost-intensive process. It requires the use of expensive equipment and often manual work as well as professional software. These are major barriers limiting the development of modern tourist platforms that promote local attractions. Information technologies offer new opportunities for the development of the services market, including the development of smart tourism services, as an integral part of the smart city concept. 3D models are an important element of this process as they form the basis for the use of new visualization technologies, such as Virtual, Mixed, and Augmented Reality (VR/MR/AR). 3D modeling provides a new opportunity to use AR/MR technology to present information about objects, virtual tours of the historic buildings, and their promotion. It also creates an opportunity to preserve the architectural heritage and preventive maintenance of buildings. Despite the increasing use of new measuring platforms and computer modeling techniques, the implementation of 3D building models in smart tourism services is still limited, focusing more on the results of scientific projects rather than on the implementation of the new ones. The paper presents an universal methodology for the inventory of historical buildings using low-cost UAVs. It describes the most important aspects related to the process of planning UAV measurement missions and photogrammetric data acquisition. The construction of 3D models and the possibilities of their further use to build smart tourism services based on Web/AR/MR/VR technology was also presented.
Soil Organic Carbon Stabilization: Influence of Tillage on Mineralogical and Chemical Parameters
Authors: De Mastro Francesco , Traversa Andreina , Cocozza Claudio , Pallara Mauro , Brunetti Gennaro
Published: September 2020

The interaction of organic carbon (OC) with clay minerals and amorphous iron and aluminum oxides, especially in the finest soil fractions (<20 μm), represents a good method for its stabilization, and different tillage practices can improve or reduce the persistence of OC in soils. This study investigates the effects of conventional (CT) and no (NT) tillage and soil depth (0–30, 30–60, and 60–90 cm) on the soil organic carbon (SOC) in four soil size fractions and its interactions with clay minerals and amorphous oxides. To identify the mineralogical composition of the four soil size fractions isolated from each soil, the X-ray powder diffraction (XRPD) technique was used with near infrared (NIR) spectroscopy, while the X-ray fluorescence (XRF) technique was used to determine the chemical composition of soil fractions. The higher OC content found in the finest soil fraction is related to its higher content of clay minerals and amorphous oxides. The SOC content is similar among CT and NT treatments as well as the mineralogical composition and the amount of amorphous oxides, suggesting that more than ten years of different tillage did not influence those parameters.
Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak
Authors: Low Zheng Yao , Farouk Isra Ahmad , Lal Sunil Kumar
Published: September 2020

Traditionally, drug discovery utilises a de novo design approach, which requires high cost and many years of drug development before it reaches the market. Novel drug development does not always account for orphan diseases, which have low demand and hence low-profit margins for drug developers. Recently, drug repositioning has gained recognition as an alternative approach that explores new avenues for pre-existing commercially approved or rejected drugs to treat diseases aside from the intended ones. Drug repositioning results in lower overall developmental expenses and risk assessments, as the efficacy and safety of the original drug have already been well accessed and approved by regulatory authorities. The greatest advantage of drug repositioning is that it breathes new life into the novel, rare, orphan, and resistant diseases, such as Cushing’s syndrome, HIV infection, and pandemic outbreaks such as COVID-19. Repositioning existing drugs such as Hydroxychloroquine, Remdesivir, Ivermectin and Baricitinib shows good potential for COVID-19 treatment. This can crucially aid in resolving outbreaks in urgent times of need. This review discusses the past success in drug repositioning, the current technological advancement in the field, drug repositioning for personalised medicine and the ongoing research on newly emerging drugs under consideration for the COVID-19 treatment.
Tick-Borne Flaviviruses Depress AKT Activity during Acute Infection by Modulating AKT1/2
Authors: Kirsch Joshua M. , Mlera Luwanika , Offerdahl Danielle K. , VanSickle Marthe , Bloom Marshall E.
Published: September 2020

Tick-borne flaviviruses (TBFVs) are reemerging public health threats. To develop therapeutics against these pathogens, increased understanding of their interactions with the mammalian host is required. The PI3K-AKT pathway has been implicated in TBFV persistence, but its role during acute virus infection remains poorly understood. Previously, we showed that Langat virus (LGTV)-infected HEK 293T cells undergo a lytic crisis with a few surviving cells that become persistently infected. We also observed that AKT2 mRNA is upregulated in cells persistently infected with TBFV. Here, we investigated the virus-induced effects on AKT expression over the course of acute LGTV infection and found that total phosphorylated AKT (pAKT), AKT1, and AKT2 decrease over time, but AKT3 increases dramatically. Furthermore, cells lacking AKT1 or AKT2 were more resistant to LGTV-induced cell death than wild-type cells because they expressed higher levels of pAKT and antiapoptotic proteins, such as XIAP and survivin. The differential modulation of AKT by LGTV may be a mechanism by which viral persistence is initiated, and our results demonstrate a complicated manipulation of host pathways by TBFVs.
Evaluation of Potential ARG Packaging by Two Environmental T7-Like Phage during Phage-Host Interaction
Authors: Liu Junlin , Liu Peng , Feng Fenglin , Zhang Junxuan , Li Fulin , Wang Mianzhi , Sun Yongxue
Published: September 2020

The increase in antimicrobial resistance is a threat to both human and animal health. The transfer of antibiotic resistance genes (ARG) via plasmids has been studied in detail whereas the contribution of bacteriophage-mediated ARG transmission is relatively little explored. We isolated and characterized two T7-like lytic bacteriophages that infected multidrug-resistant Escherichia coli hosts. The morphology and genomic analysis indicated that both phage HZP2 and HZ2R8 were evolutionarily related and their genomes did not encode ARGs. However, ARG-like raw reads were detected in offspring sequencing data with a different abundance level implying that potential ARG packaging had occurred. PCR results demonstrated that six fragments of genes (qnrS, cmlA, tetM, blaTEM, sul3, mcr-1) were potentially packaged by phage HZP2 and four (qnrS, cmlA, blaTEM, mcr-1) by phage HZ2R8. Further quantitative results showed that ARG abundance hierarchies were similar. The gene blaTEM was the most abundant (up to 1.38 × 107 copies/mL) whereas cmlA and qnrS were the least. Moreover, the clinically important mcr-1 gene was the second most abundant ARG indicating a possibility for spread through generalized transduction. Together, our results indicated that these structurally similar phage possessed similar characteristics and potential packaging during phage-host interaction displayed an ARG preference rather than occurring randomly.
Epidemiology and Management of BVDV in Rangeland Beef Breeding Herds in Northern Australia
Authors: McGowan Michael , McCosker Kieren , Fordyce Geoff , Kirkland Peter
Published: September 2020

Approximately 60% of Australia’s beef cattle are located in the vast rangelands of northern Australia. Despite the often low stocking densities and extensive management practices of the observed herd, animal prevalence of BVDV infection and typical rates of transmission are similar to those observed in intensively managed herds in southern Australia and elsewhere in the world. A recent large three- to four-year study of factors affecting the reproductive performance of breeding herds in this region found that where there was evidence of widespread and/or recent BVDV infection, the percentage of lactating cows that became pregnant within four months of calving was reduced by 23%, and calf wastage was increased by 9%. BVDV is now considered the second most important endemic disease affecting beef cattle in northern Australia, costing the industry an estimated AUD 50.9 million annually. Although an effective killed vaccine was released in Australia in 2003, the adoption of routine whole herd vaccination by commercial beef farmers has been slow. However, routine testing to identify persistently infected replacement breeding bulls and heifers has been more widely adopted.
Mis-Genotyping of Some Hepatitis D Virus Genotype 2 and 5 Sequences Using HDVdb
Authors: Charre Caroline , le Gal Frédéric , Dény Paul , Scholtès Caroline
Published: September 2020

Evidence that Hepatitis D virus (HDV) genotype is involved in HDV infection pathogenesis is increasing. Indeed, HDV genotypes have been shown to be linked to different outcomes in terms of liver fibrosis and treatment response. Herein, we show that the promising HDVdb genotyping tool available online can lead to wrong genotyping results. The current HDVdb algorithm should be carefully considered as a “beta-version” and warrants algorithm core corrections, as soon as possible, for an optimal and beneficial use.
Physicians’ perspectives on estimating and communicating prognosis in palliative care: a cross-sectional survey
Authors: Engel Marijanne , van der Ark Andrée , van Zuylen Lia , van der Heide Agnes
Published: September 2020

Background

Advance care planning (ACP) can help to enhance the care of patients with limited life expectancy. Despite physicians’ key role in ACP, the ways in which physicians estimate and communicate prognosis can be improved.

Aim

To determine how physicians in different care settings self-assess their performance in estimating and communicating prognosis to patients in palliative care, and how they perceive their communication with other physicians about patients’ poor prognosis.

Design & setting

A survey study was performed among a random sample of GPs, hospital physicians (HPs), and nursing home physicians (NHPs) in the southwest of the Netherlands (n = 2212).

Method

A questionnaire was developed that had three versions for GPs, HPs, and NHPs. Each specialism filled in an appropriate version.

Results

A total of 547 physicians participated: 259 GPs, 205 HPs, and 83 NHPs. In the study, 61.1% of physicians indicated being able to adequately estimate whether a patient will die within 1 year, which was associated with use of the Surprise Question (odds ratio [OR] = 1.65, P = 0.042). In the case of a prognosis of <1 year, 75.0% of physicians indicated that they communicate with patients about preferences regarding treatment and care, which was associated with physicians being trained in palliative care (OR = 2.02, P=0.007). In cases where patients with poor prognosis are discharged after hospital admission, 83.4% of HPs indicated that they inform GPs about these patients’ preferences compared with 29.0% of GPs, and 21.7% of NHPs, who indicated that they are usually adequately informed about the preferences.

Conclusion

The majority of physicians indicated that they believe they can adequately estimate patients’ limited life expectancy and that they discuss patients’ preferences for care. However, more physicians should be trained in communicating about patients’ poor prognosis and care preferences.
Ensuring Public Order during the Court Hearings in the Context of Reforming the Judicial System of Ukraine
Authors: Dzhafarova Maryna Vyacheslavivna , Ivanova Hanna Sergiivna , Zahorodniuk Svitlana , Zaiets Uliana Olehivna
Published: September 2020

The relevance of the issue raised in the article is due to the fact that one of the key aspects of reforming the judicial system in Ukraine, which must meet European standards, is to ensure public order during the court hearing. In this regard, the subject matter of the article is the world-tested methods and ways of ensuring public order during the court hearing. While writing the article the authors have used the following methods: formal and legal, analytical, system analysis, system and structural. The problems that currently exist and are in the way of effective development of the national judicial system of Ukraine have been analyzed. While analyzing the most problematic and relevant issues of ensuring public order in courts the authors have emphasized on the intensification of tendencies to strengthen the security of the subjects participating in the court hearing. At the same time, it has been stated that there is the spread of the policy of many states for increasing the level of democratization of the judicial process, in particular by granting wider rights and freedoms to all its participants. Based on the successful experience of foreign countries, the authors have suggested the ways to improve the judicial process in Ukraine in the whole and not just to ensure public order during the court hearing. Special attention has been paid to the Judicial Protection Service. It has been determined that the improvement of the national legislation of Ukraine on ensuring public order during the court hearing should take into account both national traditions of judicial proceedings and European standards. At the same time, the implementation of international standards in these areas should be systematic and comprehensive. In this regard, it is necessary to form a single concept in this area. The conclusions have offered three main interrelated stages of improvement of the legislation of Ukraine in terms of ensuring public order during the court hearing.
Investigation of Place Attachment and Sense of Belonging from the Perspective of the Residents - Samanbahçe Social Residences as Case Study
Authors: Aygenç Beren , Özburak Çimen , Uzunoğlu Semra Sema
Published: September 2020

For each individual, the residence he lives in is his domain and expresses the limits of privacy. In other words, the house is the private space where people express themselves and even feel themselves part of it. In this context, the relationship between the human and the residential environment is gaining importance. In the study carried out, the concepts of spatial identity, satisfaction, belonging, and human-space, human-environment relationships were examined. Samanbahçe Houses, the first social housing example built in the Ottoman period in Nicosia, North Cyprus, was selected as the study area. In the study, a questionnaire survey was conducted, including questions about human-space, human-environment relationships, spatial features, and questions about the sense of belonging-place attachment. The numerical data obtained in the survey study were analyzed together with user opinions. In the research and observations made within the scope of this study, which will contribute to future studies on Samanbahçe Houses, many spatial deficiencies and renovation needs were identified in the houses built based on user needs and expectations time they were constructed. On the other hand, the results of the interviews and surveys conducted with the users revealed that the degree of belonging and satisfaction of the people living in this area regarding their home and environment is quite high. Samanbahçe Houses continue to live as a sustainable example of social, cultural, environmental, and indoor features.
The Impact of Micro-finance on Self-employment and Poverty Reduction: A case of Sindh Rural Support Organization and Tameer Micro Finance Bank, Sindh
Authors: Ahmed Israr , Khoso Imamuddin
Published: September 2020

Micro finance is well-organized and successful instrument to decrease poverty. Although microfinance Sector in Pakistan has recognize important development and attain little cost formations. The major reason of study is to forecast that how Micro finance decreases poverty or not and method of self-employment in rural and urban of Sindh successful or not. A most important mean of this research article was to calculate that what type of Impact of microfinance on reduction of poverty and Self-employment with Supply lending and Demand following hypotheses theory. Researcher used Stratified random sampling technique 500 clients of each organization (TMB and SRSO) was selected for testing PLS with Smartpls 3. After assessment of responses with the help PLS of measurement and structural model result shows positive impact of independent variable (IV) on Dependent variables (DVs).
Organizational and Legal Principles of Ensuring Academic Autonomy of Higher Educational Institutions
Authors: Yevdokimenko Svitlana Viktorivna , Inshyn Mykola Ivanovich , Salmanova Olena , Polstyanoy Andriy
Published: September 2020

The objective of the article is to determine the content and specific features of organizational and legal principles for ensuring the academic autonomy of higher educational institutions. In order to achieve this objective, the authors used the following methods of scientific cognition: dialectical, formal and legal, bibliographic.
Problematic issues that are directly related to the implementation of legal norms for ensuring academic autonomy of higher educational institutions have been studied. The authors have formed own definitions of such concepts as “academic autonomy of educational institutions”, “organizational provision of academic autonomy” and “legal provision of academic autonomy”. Historical stages of formation and development of academic autonomy have been considered. Foreign and international norms regarding the observance of academic freedom and honesty in the most developed democratic countries of the world have been characterized. Suggestions for improving academic mobility, academic autonomy and academic freedom both in Ukraine and in the world have been provided.
Impact of the worldwide trends on the development of the digital economy
Authors: Voronkova Valentyna H. , Nikitenko Vitalina A. , Teslenko Tatyana V. , Bilohur Vlada E.
Published: September 2020

The aim of the article is to develop a new model of the digital economy as a new scientific direction of the philosophy of economics. Analysis methodology is the use of methods such as cross-cultural, systemic, synergetic, informational, axiological, cybernetic to develop a new model of the digital economy as a new scientific direction, in the context of which a new information space is being formed. The problems of solving the digital economy are taking place against the backdrop of new trends - globalization 4.0, Industry 4.0, Enlightenment 2.0, Agile management, in the context of which there is a transition from simple interconnection to hyperconnection and the spread of Moore's law, according to which there is a doubling of information. The results of the study. 1) The development of the digital economy as a new scientific field, which is based on a combination of concepts of informatization, digitalization, robotics, developing under the influence of global trends is studied. 2) It has been established that the digital economy contributes to technological progress and, under the pressure of global trends, develops a variety of economic models of scientific, technical and digital progress, which are based on the solution of problems of man, science, society. 3) The problematic issues of the digital economy and the conditions for its solution are identified. Conclusions. The prospects that the digital economy opens up thanks to modern technologies representing a technological breakthrough are analyzed. The digital technology network is designed so that it moves with the least loss and the smallest pieces of calculus are at the heart of this new constant flow system. All this indicates that in the context of globalization and the BIG DATA era, humanity is entering a new stage of calculus, when information doubles in accordance with Moore's law.
Pre-Hispanic Ophthalmology
Authors: Dalma-Weiszhausz José
Published: September 2020

The pre-Hispanic cultures of Mesoamerica had a complex set of beliefs, philosophy and comprehensive medical knowledge. Their concept of the nature of disease included their place in nature, the universe, and their relationship with their gods and astrology. Unfortunately, most of that information was lost but what remains highlights a native herbal pharmacopeia and surgical abilities on par with their European counterparts from that time. Some of these remedies are still widely used as folk medicine in the region. prehispánico, precolombino, Mesoamérica, oftalmología, historia, remedios herbolarios, cirugía, códice, de la Cruz-Badiano; Florentino; de Sahagún Bernardino.
Encefalopatía hepática: historia natural de la enfermedad, nueva clasificación e impacto en la calidad de vida
Authors: Abdo Francis Juan Miguel , Ariño Suárez Mauricio de , Castro Narro Graciela Elia , Malé Velázquez René , Ramos Gómez Mayra Virginia , Rizo Robles María Teresa , Velarde Ruiz Velasco José Antonio
Published: September 2020

Hepatic Encephalopathy (HE) is a term including a wide range of neuropsychiatric changes, secondary to chronic hepatic damage. In Mexico, there is scarce epidemiological data about cirrhosis; thus, its prevalence is unknown. In 2000, cirrhosis was the fifth cause of death and in 2011 INEGI reported that digestive diseases were the fifth most common cause of mortality: in 2013, cirrhosis was the fourth cause of death. It has been estimated that by 2020 there will be 1,496,000 patients with cirrhosis, and by 2050 the figure will rise to 1,866,000. Therefore, an analysis was carried out in order to propose the new classification as a tool to calculate the epidemiology of hepatic encephalopathy and cirrhosis in Mexico, as well as to evaluate its impact on quality of life. Based on the historical descriptions of the HE, the natural history of the disease was reviewed focusing on the classifications. The results showed that the minimal hepatic encephalopathy requires, like any other subclinical hepatic encephalopathy, a meticulous clinical testing. Regarding the quality of life, several researchers have associated improvement with the treatment for hepatic encephalopathy. The authors conclude that hepatic encephalopathy must be classified according to the underlying etiology, clinical severity, course of time, and triggering factors analyzed in the latest international guidelines.
Drug Approval Process for Pediatric Patients
Authors: Castelán Martínez Osvaldo D. , Barrios López Victoria E.
Published: September 2020

Before placing a drug on the market for human use, it must be comprehensively studied in preclinical and clinical studies to ensure it is safe, high-quality and effective to be used in the target population. Nevertheless, there are not enough studies carried out for the pediatric population. Many of the medications currently used to treat the pediatric population have not been authorized for such use. Problems resulting from inadequate adaptation of adult medications for children include inadequate dosing which leads to increased risk of adverse reactions including death, ineffective treatment, non-availability to the pediatric population of therapeutic advances, non-suitable formulations, lack of formulations and inadequate administration routes, as well as use of magistral or officinal formulations to treat the pediatric population which may be of poor quality. The development of pediatric medicines will lead to safe and accurate administration, reducing the risk of medication errors, improving adherence to medication and improving therapeutic outcomes in children. For these reasons, it is necessary that the regulatory authorities in each country encourage the research and development of pediatric medicines. The objective of this article was reviewing the pharmacological and regulatory aspects involved in the development of pediatric medications, as well as describing the current status of pediatric drug development in Mexico.
Chemotherapeutic Complications in Adult Colombian Patients with Acute Lymphoblastic Leukemia in Hospital San Rafael: A Descriptive Study
Authors: Castro Vásquez Carlos Alberto , Quiñones Ossa Gabriel Alexander , Pineda Castañeda María Alejandra , Maldonado Gantiva Diana Carolina , Casas González Julián Stiven , Cubillos Rojas Julián David , Álvarez Rodríguez José Camilo , Torres González Cesar Humberto , Díaz Muñoz Gustavo Alfonso
Published: September 2020

Background. Acute Lymphoblastic Leukemia (ALL) is a hematolymphoid neoplasm with multiple complications and variable prognosis, which depends on several factors, one of them related to chemotherapeutic treatment. Objective. To describe the complications developed in patients diagnosed with ALL and who received chemotherapy treatment in Hospital San Rafael. Materials and methods. A retrospective analysis of clinical, paraclinical and demographic variables taken from clinical records of adult patients diagnosed with ALL admitted to hospital between 2016 and 2017. Results. A hundred and sixteen patients had hematological malignancies, 24 had ALL. Most of them had B-cell precursor ALL (79.2 %), 86.4 % were in the chemotherapy induction phase, 87.5 % developed febrile neutropenia, 37.5 % had tumor lysis syndrome, 58.3 % developed infectious complications, and 45.8 % died. Discussion. This is the first study known to date describing the complications in patients with ALL at Hospital San Rafael in Colombia. One of the major findings was the high frequency of febrile neutropenia episodes and infectious complications mainly associated with unfavorable outcomes, such as multiple organ failure and death. Therefore, clinicians should always have these complications in mind when a patient with hematological malignancies is receiving or is about to start a chemotherapeutic regimen. Conclusions. Bloodborne and respiratory tract infections were the most common sources of infection by Staphylococcus epidermidis and Klebsiella pneumoniae as causative agents. Likewise, the most frequent complication was febrile neutropenia. The first cause of death were infections complicated by sepsis; however, only one-third of the patients had a microbial isolation.
Distrés en adultos con enfermedad oncológica terminal y con enfermedades sistémicas avanzadas no terminales: un estudio prospectivo observacional
Authors: Sánchez-Román Sofía , Beltrán-Zavala Cristina , Barrientos-Casarrubias Vania , Alfaro-Espejel Itzel , Quiróz-Friedman Paulina , Mejía-Castrejón Jessica , Pacheco-Arroyo Diana , Montelongo-Niño Diana , Lara-Solares Argelia , Chiquete Erwin
Published: September 2020

Introduction. Distress impacts the quality of life and death of patients with advanced oncologic disease. Objective. To compare the frequency of perceived distress of adults with advanced and systemic oncologic disease, as well as to identify the main affective correlates by means of simple relative frequencies in percentages. Material and Methods. In this descriptive study we evaluated adults with stage IV oncologic disease, who knew their terminal status, who were managed in a palliative care (PC) clinic; and patients with non-terminal advanced disease not attending a PC clinic. The Palliative Performance Scale: PPS, Edmonton Symptom Assessment Scale and The Distress Thermometer) were applied to evaluate the frequency and severity of distress. Results. Both groups had a mean of 25.4 ± 35.5 months with the disease. PPS score was lower in patients receiving PC (49.3 ± 19.0) comparing with the non-terminal ones (61.2 ± 17.1) (p < 0.05). The prevalence of distress was 71.4 % (75 % in PC patients, and 70 % in the second group). The main problems perceived by both groups were physical (pain, 41 %) and emotional (sadness, 22 %). Patients not receiving PC perceived more practical problems (economical), as compared with the terminal patients (17.2 % vs. 8.8 %, respectively; p < 0.05). Compared with men, women reported less tranquility, more sorrow and fear (p < 0.05). Conclusions. The prevalence of distress in our patients with advanced disease is among the highest reported in literature. The distinguishing characteristics of patients with terminal disease are different from those with a less advanced process.
Methods of An Open - Label Proof - of - Concept Trial of Intravenous Valproic Acid for Severe COVID-19
Authors: Chiquete Erwin , Toapanta-Yanchapaxi Liz , Cantú-Brito Carlos
Published: September 2020

Introduction. Coronavirus disease 2019 (COVID-19) is the systemic entity caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may cause death through severe atypical pneumonia and acute lung injury. Valproic acid (VPA) has shown anti-inflammatory activity and intrinsic antiviral effect. These properties warrant the study of VPA as a possible active treatment in people with severe COVID-19. Material and Methods. Consecutive adult patients needing invasive mechanical ventilation (IMV) will be given intravenous (IV) VPA at a starting dose of 20 mg/kg/day and up to 60/kg/day (in 60 min IV infusions in 250 mL normal saline) as needed to reach plasma VPA concentrations of 50-100 μg/mL (measured every 72 h). These patients will be followed-up for 10 days for the primary outcome and for a further period of 30 days after treatment completion for the secondary outcome of recurrence. The primary study outcome is the reduction in the case fatality rate (CFR) of at least 50 % after 10 days of treatment (as compared with natural history). Secondary outcomes are the reduction of length of stay (LOS) of at least 50 %, as well as COVID-19 recurrence at 30-day follow-up. The most important safety outcomes are acute liver failure, acute pancreatitis, and thrombocytopenia. Conclusions. Although long-term adverse effects and even pro-inflammatory consequences have been reported with the chronic use of VPA, the study of VPA is justified from a scientific standpoint given the urgent need for a drug against COVID-19 to shorten the high mortality and LOS.
DÜNYA SAĞLIK ÖRGÜTÜ’NÜN COVID-19 PANDEMİSİNDE KÜRESEL SÜRVEYANS ÇALIŞMALARI
Authors: Gölbaşı Selva Dilan , Metintas Selma
Published: September 2020

Derlemenin amacı, 2019 Aralık ayında gündeme gelerek tanımlanan COVID-19 (Koronavirüs Hastalığı-2019) ve etkeni olan SARS-CoV-2 bağlamında 2020 yılının ilk aylarında Dünya Sağlık Örgütü önderliğinde yaşanan gelişmeleri ve çalışmaları, yayımlanan raporlar ile ortaya koymaktır. SARS-CoV (Ağır Akut Solunum Yetersizliği Sendromu ile ilişkili koronavirüs) ve MERS-CoV (Orta Doğu Solunum Sendromu ile ilişkili koronavirüs) ile aynı ailede yer alıp bu virüslerle olan benzerlikleri ve farklılıkları ile kendini gösteren SARS-CoV-2, önce bir pandemiye, ardından bir infodemiye yol açarak insanlık tarihindeki yerini almıştır. Pandeminin ilk aylarında ulaşılan hastalık ve etken ile ilgili bilgilerle beraber DSÖ önderliğindeki salgın yönetiminde küresel sürveyans özetlenerek halk sağlığı prensipleri vurgulanmıştır.
EATING HABITS CHANGES DURING COVID-19 PANDEMIC LOCKDOWN
Authors: Mehmet Nimetcan , Özlem Arzu
Published: September 2020

The COVID-19 pandemic outbreak affects all populations. Eating habits and lifestyle changes during COVID-19 lockdown. Aim of this paper is to explore eating habits changes during the COVID-19 pandemic lockdown. A systematic review was conducted by using the PubMed database and Google scholar to find articles published from between March and July 2020. only English and Turkish published articles were included. Total nine article were analyzed. The effect of COVID-19 lockdown on dietary habits differed from community to community. The quarantine has positive and negative effects on eating habits such as returning to home meals and reducing fast food consumption while eating frequency was increased due to quarantine and stress.
Antiparasitic activity of Ophiocomina nigra in Entamoeba invadens
Authors: Sánchez-Ramos Sanjuana , Valdes-Santiago Laura , Castruita-Domínguez José Pedro , Villagómez-Castro Julio César
Published: September 2020

Objetive: Analyze the antiparasitic activity of marine invertebrate Ophiocomina nigra in Entamoeba invadens. Methodology. In O. nigra, an analysis of the quantitative proximal chemical composition (moisture, ash, protein, lipids and nitrogen-free extract) was performed. In addition, the determination of the total protein pattern (SDS-PAGE 10%). On the other hand, the antiparasitic activity of E. invadens trophozoites was determined, which were grown in TYI medium at 28 ° C and exposed to the aqueous extract of O. nigra for 24 hours. Subsequently, metabolic activity (XTT assay) was determined and morphology was analyzed. Cytotoxicity tests were performed on human liver cells (Hep G2) exposed for 24 hours to O. nigra (XTT test) and the biomass was determined (violet crystal staining). Contribution. The antiparasitic activity of O. nigra in E. invadens and the cytotoxic effect in human liver cells was determined. There are few scientific studies of this marine invertebrate on its use in traditional medicine, so it is important to analyze its effects and therapeutic value.
Determination of the microbiological load in organic, industrial and transfer type eggs in the central-west region of the State of Veracruz
Authors: Jimenez-Hernandez Magdalena , Nava-Valente Noemi , Del Angel-Coronel Oscar Andrés , Frias-Frias Rocío
Published: September 2020

El objetivo del presente trabajo fue determinar la carga microbiológica en huevo de traspatio, tipo orgánico e industrial de la región centro-occidente del estado de Veracruz. Se evaluó la presencia de microorganismos patógenos en los tres sistemas de producción y se determinó la calidad microbiológica de cada uno de estos sistemas. Lo cual es de suma importancia considerando que en huevo con alta carga microbiológica, pueden estar presentes microorganismos como Salmonella spp S. enteritidis, etc., los cuales son considerados agentes causales de infecciones entéricas en la población. Aunado a lo anterior, los sistemas de explotación antes mencionados, representan una fuente de ingreso económico relevante para las familias que habitan esta región. Para el análisis microbiológico, se tomaron diferentes muestras de cascaron y de la parte interna (clara y yema). Se evaluó la presencia de Salmonella spp aplicando el procedimiento establecido en la Norma Oficial Mexicana NOM-114-SSA1-1994. Además se realizaron pruebas físicas para evaluar si los defectos físicos en huevo pueden correlacionarse con la presencia de Salmonella spp u otras bacterias. Contribución: Actualmente es poca la información que existe sobre la calidad microbiológica, en huevo proveniente de los diferentes sistemas de explotación que se consumen en la región centro-occidente del estado de Veracruz, particularmente para el sistema orgánico y de traspatio.
Phylogenetic analysis of Na+/H+ (NuoL/MrpA) antiporters
Authors: Sánchez-Calderón Lenin , Chávez-Avilés Mauricio Nahuam , Díaz-Pérez Alma Laura , Gómez-Luna Blanca Estela , Ramírez-Granados Juan Carlos , Veloz-García Rafael Alejandro , Díaz-Pérez Césa
Published: September 2020

Objectives: Sodium/proton (Na+/H+) antiporters NuoL/MrpA-like proteins are important in monovalent cations homeostasis, ATP synthesis, are involved in growth using low concentrations of acetate, and in management of protons during methane production. To learn more about the evolutive origin and biological relevance of this protein, in this work a phylogenetic analysis of the NuoL/MrpA superfamily of proteins was done. Methodology: Phylogeny reconstruction was done with 596 NuoL/MrpA proteins and 39 MrpD-NuoM/N proteins. The algorithms used were minimum evolution and maximum likelihood, using MEGA program. Additionally, a conserved domain analysis was done. Contribution: NuoL/MrpA superfamily and their homologous proteins, MrpD-NuoM/N, form two paralogous groups. The NuoL/MrpA superfamily consists of two families. Family NuoL consist of arqueal, bacterial and eukaryotic proteins of around 600 aa in size. Family MrpA are formed by proteins from bacteria and archaea, with a 600 to 850 aa in size. Using the phylogenetic analysis and conserved domain analysis, a superfamily NuoL/MrpA evolution model was proposed.
Calidad de vida laboral percibido según el nivel de estudios del personal administrativo y académico de las preparatorias del municipio de Etchojoa, Sonora
Authors: Quiroz-Campa Cecilia Yaneth , Miranda-Camacho Daniela , Galvan-Corral Alberto , Acosta-Mellado Erika Ivett
Published: September 2020

The objective of the study was to determine the level of quality of work life perceived by the administrative and academic staff according to their level of studies of the high schools of the municipality of Etchojoa, Sonora. Methodology: the research was quantitative, since it was carried out through the application of an instrument with numerical measurement scale to measure the variables of quality of work life and the level of studies between three high schools in a municipality, where It has a scale from 1 to 10; The subject of study in this way is part of a type of non-probabilistic sampling with 73 participants, where 39.7% of the staff have a bachelor's degree, continuing with a 32.9% with postgraduate, 17.8% with high school and only 9.6% have their level of studies until secondary. Contribution: the CVL, according to the level of studies offered by the campus is 7.5714; and the CVL that each person generates individually, is 8.5714. Likewise, a comparative analysis was carried out using the t-test for equality of means, with a 95% reliability, which showed that there are significant differences between the level of quality of life of the staff and the level of studies.
Alexa Skills como herramientas de apoyo en una clase de Inglés para el desarrollo de las habilidades de Speaking y Listening
Authors: Cordova-Osorio Luis Alberto , Ortega-Gines Héctor Bernardo , Galicia-Garcia Christian , Escobedo-Garcia Juan Diego
Published: September 2020

The project has as main objective to use Alexa skills in order to generate more personalize experiences (intents) within a classroom in the English Language teaching creating voice commands. The programmed skills are meant to develop two out of four main abilities a student must acquire when learning English as a second language, Speaking and Listening. The first step in the development methodology was to select the topics the students find more difficult to learn, after that with the help of English teachers different conversation models were generated. In the third step the skills were programmed based on the conversations previously generated. Finally the skills were tested in a classroom by intermediate level students. This project has proved to make English class more interactive, it has also allowed students to develop speaking and listening skills in a more natural way.
La importancia de la gestión directiva en la escuela
Authors: Chávez-Morales Ignacio , Chávez-López Pedro Jacob , Lino-Gamiño Juan Alfredo , Magdaleno-Castro Benigno
Published: September 2020

The work presented here addresses the importance of leadership and management by the principal in the school in relation to the education that the new century needs; it is essentially focused on rescuing the significance of the leadership role in the leadership and management of the school. For the research have been set general and specific objectives that seek basically to know and rescue the importance of the role played by the director of the institution, on the one hand, and on the other, to know the different theories about leadership and management that informing directors know for the study. For these purposes, an exploratory type study was carried out with a two-variable hypothesis; the importance of management and leadership, for verification, a survey (as validation) was applied to 8 directors of the Municipality of Tecomán, Colima. The final part of the document details the results, findings and conclusions, among which the fact that the degree of updating of the director is decisive to define his leadership style, highlighting the importance of his proper management of resources of all kinds within the school and for each of the activities.
Sincronización de datos en el contexto de procesos terapéuticos de rehabilitación física
Authors: Ramírez-Hernández Marco Antonio , Santos-Quiroz Randolfo Alberto
Published: September 2020

In the development of an information platform focused on the daily operations of a physical rehabilitation clinic, two main software components are currently being worked on for their interaction with users. A web application focused on the operations of labor personnel (specialists and training professionals) and a native mobile application focused on the actions of patients, each of them has the need to interact with the same information repository, analyzing the side of the Patient problems arise from permanent connectivity to the main data through the Internet or some other data transmission protocol, the requirement arises to be able to interact with the generated personal information, which could be achieved by synchronizing data between client-server.
Estructura de la planeación normativa como un proceso para la consolidación del Comité de Seguridad Informática en Chihuahua, Chih
Authors: Córdova-Villegas Perla Cristina , Medina-Nuñez América Libertad , Moreno-Ojeda Esperanza Raquel , Barroso-Barajas Alfonso José
Published: September 2020

Nowadays there is a need to fortify the Information Security of organizations, which increase the interest of the private sector to work collaboratively with researchers and educators to structure an organism that allows to asses those who require advice in this area. This is how the Information Security Committee emerges and that is how results the need to create the sense of how it will act. Objectives: Make a diagnostic of the perception of the Information Security Committee about the elements that form the normative planning of organizations. Create the mission, vision and define of the Information Security Committee. Methodology: The project is based on a qualitative research, in which five members of the Information Security Committee a fill an semi structured interview to link the processed knowledge with the context where the professional activity is developed. Contribution: Making the normative planning for the Information Security Committee, creation of the mission, vision and the definition of the values that will provide a guide for the establishment of the objectives and strategies.
Implementación de TIC’S para la gestión de Visitas de divulgación de la científica
Authors: Magdaleno-Zavala Juan Antonio , Duran-Belman Israel
Published: September 2020

The Irapuato Higher Technological Institute has the "Itinerant Laboratory" program, a project that carries out various scientific dissemination activities that are offered to educational institutions in the state of Guanajuato; However, poor communication between Responsible led to various problems that prevented the provision of the services of this itinerant laboratory; In 2017, a total of 32 applications were made by primary and secondary schools, of which only 12 were met, due to the lack of organization and the time it took to complete the process. In order to mitigate these delays and increase the number of visits, it was decided to use IT by designing a web system through which educational institutions can request visits. The methodology followed for software development is based on the cascade life cycle; It culminated with a web system that manages the requests for visits as well as the existing recreational activities in addition to providing reports of attention and number of people benefited, resulting in an increase in requests received by 30% and attention to them with a 40% increase compared to the previous year.
Redes Sociales como estrategia de comercialización en las empresas de manufactura automotriz
Authors: Rico-Chagollán Mariana , Chacón-Olivares María Del Carmen , Rodríguez-Campos Juan Carlos , Hernández-Negrete Marcos Jesús Alejandro
Published: September 2020

The present work addresses current issues, such as the use of Information Technology and its incorporation into the business plan of organizations in the automotive sector. Therefore, a quantitative analysis and data collection was carried out, which made it possible to establish the use of social networks as a marketing tool, to help improve the traditional means dissemination of effective communication strategies in the markets, as well as impacting on the development of successful digital campaigns that allow the positioning of their brands and services. Therefore, it was detected that 68% of the total sample shows that they are willing to use social networks for the dissemination and promotion of digital campaigns, and it was 95% the possitive answers in the surveys yielded positive data, regarding the use of social networks of each organization, being the most common Facebook, Instagram and YouTube. Therefore, it was determined that the use of social networks for their coverage is considered effective as a tool in the use of marketing design processes.
Diagnóstico sobre desarrollo de competencias informacionales y digitales en posgrados del Centro Universitario del Norte
Authors: García-Cruz Luis Gerardo , Cornejo-Álvarez Juan Fidel , Villalón-De la Isla Estela Maricela , Ceballos-Macías Jorge Daniel
Published: September 2020

The purpose of this study is to present a diagnosis of the level of development of the informational and digital competencies that the postgraduate students of the University Center of the North (CUNorte) possess. These two variables of Information Literacy are evaluated through a questionnaire organized in five dimensions: capacity, access, evaluation and use of information; and basic notions in the use of Information and Communication Technologies (ICT). The results show evidence of some of the competencies acquired by students and graduates of postgraduate courses, however there are opportunities to strengthen their disciplinary development and facilitate their research processes. The answers provided by the students and their consecutive analysis highlight the need to complement the diagnosis using other techniques to assess the knowledge and skills that make up the informational and digital competencies whose development is evaluated. Regarding the contribution of the study, considering the factor analysis of the component matrix rotated in the instrument, it is summarized that it is feasible to develop a diploma that provides the necessary tools to enrich the aforementioned competencies.