bluuebunny/crossref_metadata_2025 huggingface dataset:
Endmember Extraction and Abundance Estimation Algorithm Based on Double-Compressed Sampling
Authors: Wang Li , Bi Yang , Wang Wei , Li Junfang
Published: May 2023

Based on double-compressed sampling, a hyperspectral spectral unmixing algorithm is proposed, which could directly complete the endmember extraction and abundance estimation. On the basis of the linear mixed model, we designed spatial and spectral sampling matrices, obtained spatial and spectral measurement data, and constructed a joint unmixing model containing endmember and abundance information. By using operator separation and Lagrangian multiplier algorithm, the endmember matrix, abundance matrix and remixing image can be quickly obtained by matrix operation. The parameters of the unmixing algorithm, including regularization parameter, convergence threshold and spatial sampling rate, are determined using synthetic simulated hyperspectral data. The proposed algorithm is applied to six groups of real hyperspectral data, and the experimental results fully verify the effectiveness and reliability of the algorithm. Compared with the algorithm that directly unmixes the original data, it is found that the proposed algorithm can effectively extract the endmembers and estimate the abundance even when there are few measurement data. Compared with the algorithm of sampling reconstruction first and then unmixing, the proposed algorithm can improve the efficiency of unmixing. Therefore, the main innovation of the proposed algorithm is that it can complete the unmixing directly from the measured data, maintain the accuracy and improve the efficiency of the unmixing.
Evaluation of COVID-19 m-Health Apps: An Analysis of the Methods of App Usability Testing During a Global Pandemic
Authors: Saeidnia Hamid Reza , Kozak Marcin , Ausloos Marcel , Lund Brady D. , Ghorbi Ali , Mohammadzadeh Zahra
Published: May 2023

Purpose: As the COVID-19 outbreak expanded over the world, governments looked for smartphone-based technological solutions to reduce the disease's dangers and prevent it. Most leading governments initially sought to use new smartphone-based applications (apps). In this study, we review articles that have evaluated these official government apps. The objective of this review is to answer the following question: “In evaluating or analyzing governmental apps for COVID-19, which methods have researchers used?”.
Methods: This study reviews existing scholarly literature, to identify and analyze the investigations into the usability evaluation of official (governmental) mobile apps developed in the COVID-19 era. Study parameters specified that articles must be originally published in peer-reviewed journals or short articles, written in English, and must be published between 2019 and 2022 and indexed in PubMed, OVID, EMBASE, Web of Science, and Scopus. Additionally, the articles had to analyze and evaluate at least one mobile app that was launched and/or supported by a government. Reports, letters to the editor, review articles, and meta-analyses were excluded; also excluded were articles processing non-governmental apps.
Results: 11 studies were identified that met the inclusion criteria. These studies evaluate a total of 40 governmental, “official”, mobile apps, developed in 41 countries from the five continents. This study finds that the heuristic method, thematic analysis, and comparative analysis are the most popular research methods used for evaluating or analyzing governmental apps for COVID-19.
Conclusion: This review of articles developed by various governments to combat COVID-19 leads the authors to conclude that most researchers sought to emphasize the strengths of these apps as opposed to limitations. Based on this review, we find that existing literature can sufficiently cover the effectiveness of these mobile applications.
Closing the Loop: Autonomous High-Throughput Strain Characterisation from Frozen Cell Bank to Product Assay
Authors: Helleckes Laura Marie , Puchta Debora , Czech Hannah , Morschett Holger , Geinitz Bertram , Wiechert Wolfgang , Oldiges Marco
Published: May 2023

Background: Modern genome editing enables rapid construction of genetic variants, which are further developed in Design-Build-Test-Learn cycles. To operate such cycles in high throughput, fully automated screening, including cultivation and analytics, is crucial. Here, we present the required steps to meet these demands, resulting in an automated microbioreactor platform that is able to close the experiment-model loop for phenotyping.
Results: First, an automated deep freezer was integrated into the robotic platform to provide working cell banks at all times. A mobile cart allows flexible docking of the freezer to multiple platforms. Next, precultures were integrated within the microtiter plate for cultivation, resulting in highly reproducible maincultures as demonstrated for Corynebacterium glutamicum. To avoid manual exchange of microtiter plates after cultivation, two clean-in-place strategies were established and validated, resulting in restored sterile conditions within two hours. Combined with the previous steps, these changes enable a flexible start of experiments and greatly increase the walk-away time.
Conclusions: Overall, this works demonstrates the capability of our microbioreactor platform to perform autonomous, consecutive cultivation and phenotyping experiments. As demonstrated in a case study of cutinase-secreting strains of C. glutamicum, the new procedure allows for flexible experimentation without human interaction while maintaining high reproducibility in early stage screening processes.
Application of Mediation in Resolving Elderly Family Issues in Malaysia: Lessons from Canada and Australia
Authors:   Faculty of Law, Multimedia University, Melaka, Malaysia, Jamaluddin Siti Zaharah , Abu Taher Mohammad ,   Department of Law, American International University-Bangladesh, Dhaka, Bangladesh, Wong Hua Siong ,   Faculty of Law, Multimedia University, Melaka, Malaysia
Published: May 2023

Malaysia is expected to be an ageing country by 2030 when 15% of her populace will be in the category of the elderly. The elderly will face various issues and challenges, such as finance along with abuse and neglect. Generally, like in other disputes, the legal mechanism is the resort for resolution. However, litigation is less preferred in this type of cases as it does not address the emotional distress suffered by the parties involved. As such, litigation is not a suitable method as it may break the relationship between the parties. Conversely, mediation, a non-adjudicative dispute resolution mechanism, is considered a potential method of dispute settlement since it is effective in addressing the issues in a family conflict involving the elderly. Due to its effectiveness, the application of mediation as a means of resolving disputes has gained global attention. Considering its effectiveness, some countries, such as Australia and Canada, apply mediation in resolving family issues involving the elderly. The use of mediation in family disputes is not new in Malaysia, however, it is yet to be applied in elderly family disputes. The objective of this article is to explore the scope of the application of mediation in elderly family issues. As such, this study adopts the qualitative approach of research where primary and secondary sources of data were gleaned from various statutes as well as existing literature, respectively. In order to underline the potential of mediation in dispute resolution, the experiences of Australia and Canada have been shared in this article. The finding indicates that due to its intrinsic excellence and usefulness, mediation can excel in resolving the disputes related to the elderly. Therefore, the paper recommends embracing mediation as a feasible dispute settlement mechanism involving the elderly in a family setting in Malaysia.
Sialorrhea in the assessment and correction of water balance in a 2 month old baby in the ICU: a case report
Authors: Lazarev Vladimir V. , Megeryan M. M. , Smirnov D. A. , Bykov M. V. , Frolov N. S.
Published: May 2023

INTRODUCTION: In some cases, saliva production (sialorrhea — hypersalivation) can be so significant that it needs to be monitored and accounted for in the assessment and maintenance of the patient's water balance. OBJECTIVE: Description of a clinical case of sialorrhea, which had a clinically significant manifestation in the assessment and maintenance of water balance in a 2-month-old child in the intensive care unit (ICU). MATERIALS AND METHODS: Baby, 2 month old, was treated in the ICU with a diagnosis: perinatal organic hypoxic-ischemic lesion of the central nervous system of a newborn, congenital pathology of the brain, respiratory failure III stage, convulsions of the newborn, neonatal coma. In the complex of specific therapy, he received enteral feeding, correction of water and nutritional status. RESULTS: On the first day of detection of sialorrhea, the level of salivation of 2.81 ml/kg/hour (the norm is 1.3 ml/kg/hour) exceeded the physiological values by more than 2 times. The excess of normal values of salivation persisted for the next two days, as well as on the 9th day of its control, which required taking into account the amount of fluid lost with saliva in the calculation of its daily requirement. No specific measures were required in the treatment of the patient to eliminate sialorrhea; within 14 days from the moment the fact of sialorrhea was established, the level of salivation returned to normal values. CONCLUSIONS: In assessing the cumulative factors that cause fluid loss in ICU patients, especially infants, it is also necessary to take into account the presence and intensity of salivation, which can manifest as sialorrhea, when calculating the volume and administration of infusion drugs.
Reflex regulation and the functional assessment possibility of the cardiorespiratory system in pregnancy: a systematic review
Authors: Shadrin R. V. , Trembach N. V. , Grigoryev S. V. , Zabolotskikh Igor B.
Published: May 2023

INTRODUCTION: Anesthesia planning for cesarean section requires knowledge of physiological and functional features a pregnant patient has in her gestational age. Proper planning reduced the perioperative critical incidents risk. OBJECTIVE: Search for data on the methods and results of assessing the cardiorespiratory status of pregnant women using methods that involve such key mechanisms of arterial baroreflex (ABR) and peripheral chemoreflex (PCR) mechanisms. MATERIAL AND METHODS: We performed a systematic review of the literature in accordance with the PRISMA guidelines. The bibliographic search was performed in December 2022 in the Medline (Pubmed), RSCI (eLibrary.ru) and Cochrane Library databases. The search keywords were: “pregnancy breath holding test”, “pregnancy chemoreflex”, “pregnancy baroreflex”, “Valsalva test pregnancy”. RESULTS: 110 documents were found, after deleting 68 papers for various reasons 42 full-text sources were analyzed, including a detailed comparative analysis of 8 sources that met totally the inclusion criteria. The design, objectives, methods, data availability, and outcomes of the studies were heterogeneous, so a meta-analysis was not performed. Were extracted and summarized data on functional changes in the work of cardiorespiratory system during pregnancy and changes in the sensitivity of the baroreflex and chemoreflex. CONCLUSIONS: The sensitivity of PCR in pregnant women can be assessed by inhalation of hyperoxic, hypercapnic and isooxic-hypercapnic gas mixtures (rebreathing test). The sensitivity of ABR in pregnant can be assessed by phenylephrine test, Valsalva test, orthostatic test, and spectral analysis of the sequences of blood pressure values and the R-R interval. The sensitivity of PCR in full-term pregnancy increases. The sensitivity of ABR in pregnant progressively decreases from the beginning of pregnancy to the end of the second trimester and increases in the postpartum period to initial level; in the third trimester of pregnancy, changes in ABR sensitivity are individual and do not have a single trend.
Bleeding disorders associated with severity of respiratory failure in COVID-19 patients: a prospective observational study
Authors: Neymark Mikhail I. , Momot A. P. , Nikolaeva M. G. , Маmаеv А. N. , Proskurin S. N. , Logvinov P. V. , Karkavina A. N. , Epp D. P. , Romanov V. V.
Published: May 2023

INTRODUCTION: Despite the progress in understanding the pathophysiology of coagulopathy in COVID-19, data about the association and phasing of pathological changes in various parts of the hemostatic system with the development of acute respiratory distress syndrome (ARDS) are insufficient. OBJECTIVE: To determine association between the severity of respiratory failure and pathological changes in the hemostatic system in COVID-19 patients. MATERIALS AND METHODS: A prospective observational study included 204 patients with a confirmed diagnosis of severe and extremely severe COVID-19. Two groups were identified according to disease outcome: fatal (n = 106) and survived (n = 98) groups. To assess dynamics of the clinical picture of the disease and to study the hemostatic profile, time points were determined: I point — the first day — admission to intensive care unit; II point — 3–5 days, III point — 7–10 days after ICU admission. The respiratory index was calculated to assess the severity of respiratory distress syndrome. Statistical data processing was carried out using the statistical software package MedCalc Version 20.110 (MedCalc Software Ltd, Belgium). RESULTS: A 2.15-fold decrease in the respiratory index was determined for fatal outcome in patients with severe and extremely severe COVID-19. The most important hemostatic parameters affecting the severity of respiratory failure are increased Willebrand factor concentration at I point of the study (21 % contribution and inverse correlation), increased plasminogen activator inhibitor type 1 (PAI-1) level on 3–5 days (35 % contribution and direct correlation), and activation of the coagulative component of hemostasis on 7–10 days (78 % contribution and direct correlation). CONCLUSIONS: The severity of respiratory failure in patients with a confirmed diagnosis of severe and extremely severe COVID-19 is gradually associated with endotheliopathy (1 day), inhibition of parietal fibrinolysis (3–5 days) and activation of the coagulative component of hemostasis by 7–10 days of ICU stay.
STUDY OF EXTENDED SPECTRUM BETA LACTAMASES & BIOFILM IN PSEUDOMONAS SPECIES ISOLATED FROM DIFFERENT CLINICAL SAMPLES
Authors:   Postgraduate Student, Department of Microbiology, Peoples College of Medical Sciences and Research Center, Bhopal, MP., Sirvaiya Poornima , Prabhu K. Tukaram ,   Assistant Professor, Professor & HOD, Department of Microbiology, Peoples College of Medical Sciences and Research Center, Bhopal, MP., Jain Khyati ,   Professor, Department of Microbiology, Peoples College of Medical Sciences and Research Center, Bhopal, MP., Sadawarte Kalpana ,   Professor & HOD, Department of Microbiology, Peoples College of Medical Sciences and Research Center, Bhopal, MP.
Published: May 2023

Background:-Pseudomonas species are Gram negative bacteria which are resistant to commonly used antibiotics. Due to the formation of biofilm antimicrobial therapy is reduced & leads to chronic bacterial infections. Therefore, we need to isolate species of Pseudomonas from different clinical samples, detect ESBL & biofilm production in them. Objective:-1. To determine percentage of Pseudomonas species isolated from different clinical samples. 2. To determine the antibiogram of Pseudomonas species isolated from the samples. 3. To detect ESBL & biofilm production in Pseudomonas species. 4. To correlate biofilm & ESBL production. Method:-The susceptibility of different clinical samples of Pseudomonas spp.was determined by using antibiotics on Muller Hinton Agar by the Kirby -Bauer disk diffusion method using Clinical & Laboratory Standards Institute (CLSI) standards. Confirmatory test for ESBL production was done as per Clinical and Laboratory Standards Institute (CLSI) 2021guidelines. For the detection of biofilm Tissue Culture Plate (TCP) method was used. TCP is considered as the gold-standard method for biofilm detection. Result:-Out of total 171 Pseudomonas aeruginosa samples 30 were ESBL producers (17.5%) & 141 were Non ESBL Producers (82.5%), 12.8% were ESBL Producers & Strong Biofilm producers, 82.45% were Strong biofilm producers & Non ESBL producers. Conclusion:-Phenotypic detection of ESBL & antibiotic resistance in P.aeruginosa should be done & both the results should be taken in consideration for better representation of resistant strains, this will help clinicians to give appropriate antibiotics so that they can treat the infections timely.
PSYCHOLOGICAL ACCEPTANCE AND WORKPLACE WELL-BEING AS A PREDICTOR OF WORK-LIFE INTEGRATION
Authors:   Student MAOP 2018 batch, Amity Institute of Psychology & Allied Sciences., Dara Prakhar , Sharma Ritu ,   Assistant Professor, Department of Psychology, Central University of Haryana, Haryana, India.
Published: May 2023

Work-life integration has emerged as an important concept of understanding in the field of organizational behavior theoretically as well as practically in the organizations. The present study was designed to comprehend the importance of work-life integration and analyze psychological acceptance and workplace wellbeing. Purposive sampling of 202 from IT sector was conducted from Delhi NCR region. It was hypothesized that work-life integration can be significantly predicted by psychological acceptance and workplace wellbeing. The results evidently indicate that psychological acceptance and workplace wellbeing shares significant covariance with work family conflict and family work conflict. A significant association was found between psychological acceptance and workplace well being. It can be concluded that organizations can take steps for better integration of human recourse policies also there can be skill-development programs in organizations for employees to deal with their work-family conflicts, by making them aware of the integration method.
The effect of recruitment and selection on salesperson performance of a vehicle manufacturing company in Nigeria
Authors: Attamah Ikechukwu , O. Okolo Victor , Okoro Deborah , Ikpo Kobi , Nnadi Nmere
Published: May 2023

Organizations should equip human resources and sales managers with the vital information and knowledge needed to recruit and select salespersons with the required qualities to help them achieve improved sales performance. This paper aims to determine a salesperson’s educational qualification, selling experience, and persuasive ability and their effect on the salesperson’s performance at Innoson Motors Manufacturing Company Ltd. The study surveyed 131 company staff to collect the data; only 120 questionnaires were correctly filled and returned. First, the study checked the instrument’s reliability (Cronbach’s alpha = 0.982). Data were then analyzed using a simple linear regression analysis. The findings revealed that salesperson educational qualification has a significant positive effect on salesperson performance (r = 0.944; t = 54.251; F = 2943.209; p < 0.05). Next, salesperson selling experience was found to have a significant positive effect on salesperson performance (r = 0.964; t = 68.905; F = 4747.922; p < 0.05). Finally, salesperson persuasive ability was found to have a significant positive effect on salesperson performance (r = 0.960; t = 64.812; F = 4200.634; p < 0.05). Hence, company managers can use the findings of this paper to understand that employing highly educated, experienced, and persuasive salespersons will lead to improved salesperson performance.
AcknowledgmentWe wish to appreciate the good work done by some of the researchers who contributed immensely to the development of the study’s framework and methodology. Among them: Professor Gerald Nebo, Associate Professor Chinedum Obikeze, Dr. John Anetoh and Dr. Wali Kemkamma. We also commend the effort of Mrs. Okolo Jennifer for typing and editing the work. In a similar tone, we wish to thank our respondents for equipping us with the required information that made this study a success.
Stabilization of β-Galactosidase Encapsulated in Pectin-Alginate Hydrogel and Hydrolysis of Whey Lactose and Whole Milk
Authors: Paiva Maykon , Paula-Elias Fabrício , Pereira Luciana , Carreiro Solange , Vieira-Almeida Erika , Silva Ezequiel , Dias Giancarlo , Xavier Michelle , Morales Sergio , Perna Rafael , Almeida Alex
Published: May 2023

The operational conditions of β-galactosidase encapsulated in pectin-alginate hydrogel were investigated as well as its catalytic activity in the hydrolysis of lactose from whey and whole milk. β-Galactosidase encapsulated in pectin-alginate hydrogel showed the best results to yields and diffusional effect and pH range. Thermostability showed considerable income gain for half-life (1.7-fold), activation energy of denaturation (31.6-fold), activation of denaturation (217.3-fold at 40 ºC; 266.8-fold at 50 ºC; 345.6-fold at 60 ºC), and entropy of activation of denaturation (−42.0 J mol-1 K-1). Reusability of encapsulated β-galactosidase was observed in 8-cycles for the milk whey lactose hydrolysis (51.9%) and 7-cycles for whole milk (55.6%), and the lactose hydrolysis was observed in 13% in milk whey and 10.3% in whole milk after 10 cycles. These results revealed an industrial application potential of β-galactosidase encapsulated in pectin-alginate hydrogel for lactose hydrolysis of milk whey and whole milk processes.
Hubungan layanan perpustakaan sekolah dengan minat baca peserta didik di SMAN 4 Kota Tangerang Selatan
Authors: Rahman Aditiya , Lolytasari Lolytasari , Munawwaroh Zahrotul
Published: April 2023

Introduction. Providing school library services to increase students' interest in reading is still an important study for school libraries. Increasing reading interest in the SMAN 4 Tangerang Selatan Library is carried out by providing collaborative services to improve scientific communication. This research needs to be carried out so that the services provided by the library can accommodate all students in reading interest services and become basic research for school libraries in the South Tangerang area.Methodology. This study uses a quantitative approach, with a correlation coefficient test to answer the hypothesis. The population is 346 students, so a sample of 186 respondents is obtained using a simple random sampling technique. Questionnaires were distributed to 186 students with Likert scale scores with four alternative answers and documentation studies to complete data collection.Results and Discussion. This study found a relationship between library services and students' reading interest, as evidenced by the contribution of 24.6% between library services and students' reading interest. In comparison, the remaining 75.4% was explained by other variables not examined. The tendency of library services to increase reading interest is still in the moderate category.Conclusion. This study describes the school's efforts to increase student's interest in reading with the strength of the services provided by the library. Reading skills need to be trained so that the more the library can provide the facilities needed for reading, the more trained students will be.
Content preservation analysis of Semarang City tourism website
Authors: Pramudibyanto Hascaryo
Published: April 2023

Background. Semarang City tourism site is a means to market the tourism business industry has not been managed properly. The niche on the tourism website has not shown a complete description of the actual conditions of a digital collection preservation effort. This study aims to analyze content preservation on tourism websites in Semarang City. The purpose of this research is to describe the excellence of Semarang City tourism website when filled with complete and attractive content.Methodology. This study on preservation analysis of tourism websites uses descriptive qualitative methods by conducting media content analysis on the tourism website http://pariwisata.semarangkota.go.id/ as tourism information navigation. The core of the problem studied is the lack of relevance of Semarang City's development plan as a smart city with the readiness of tourism information. Results and discussion. The results of the content analysis of the preservation of the site found that the content of the site has not fully conveyed actual and interesting ideas, ideas, or information.Conclusions. Preservation efforts have been done well, but the quality of this niche on the site needs to be improved. This site is still undergoing an application maintenance process so there is a delay in updating the site content. Suggestions for site improvement include providing opportunities for the community to send coverage products about tourism activities through an editing process to harmonize the content with other aspects of beauty. Visitors expect an honest statement from the site manager to apologize that this site is undergoing application maintenance or preservation so that visitors can figure out the actual situations
Hybrid membrane process for water treatment: a short review
Authors: Saha Pratik , Jampa Surendra Sasikumar , Sinha Manish Kumar , Khuntia Snigdha
Published: May 2023

Water shortage is one of the most difficult issues confronting people all over the world. Rapid urbanization and water scarcity necessitate immediate action to improve sustainable water management without jeopardizing global socioeconomic growth. Thus, conventional water treatments are implemented for the purpose of eradicating various pollutants in wastewater. Traditional water treatment methods, whether in water treatment facilities or reverse osmosis (RO) plants, have run across a number of roadblocks that have significantly hampered their performance and efficiency. Integrating the membrane process with other remediation technologies in a hybrid process is a novel technique to improve contaminant extraction efficiency for our target streams. This process is termed the hybrid membrane process (HMP). On this aspect, this paper would highlight the benefits of using the HMP compared to conventional methodologies and their applications conducted in various sectors around the world. Some case studies are also reviewed illustrating its cost analysis in comparison to conventional methodologies accentuating the merits of using HMPs.
Assessment of the Coefficient of Tension in the Labor Market. Regional Aspect
Authors: Koshevoy O. S.
Published: May 2023

.Assessing the situation in the labor market of the region, and ultimately forecasting the level of employment and unemployment, is a complex multidimensional  mathematical  problem  that  does not have a reliable and proven solution to date. Research in the direction of creating evaluation methods and forecasting the situation on the labor market is an actual task. The subject of the work is an assessment of the situation on the labor market of the Volga Federal District, through the analysis and modeling of the coefficient of tension in the labor market. The purpose of the study was to develop a methodology that allows making a preliminary forecast of the situation on the labor market of the subject of the Volga Federal District. The information base of the study was the results of a sample survey of the labor force conducted by state statistics bodies in accordance with the classifier of objects of administrative-territorial division (OKATO – Russian Classification on Objects of  Administrative  Division).  To  date, the length of the time series is four time periods (2018–2021) of the year. As methods of analysis and modeling, methods of descriptive statistics were used, as well as mathematical modeling of the relationship between the coefficient of tension in the labor market and the rating index of the socio-economic situation of the Volga Federal District. It is shown that the statistical grouping of the coefficient of tension in the  labor  market  as  a  whole  for  all  subjects  of the Russian Federation is extremely heterogeneous, which makes it difficult to model processes in the labor market. At the same time, the statistical grouping of the coefficient of tension in the labor market of the regions of the Volga Federal District is quite homogeneous, which makes it possible to carry out simulations using such an integral index as the rating of the socio-economic situation of the subject of the Volga Federal District. In the process of modeling in the environment of the SPSS computer program, a nonlinear regression model of the relationship between the coefficient of tension in the labor market (dependent variable) and the place in the rating of the socio-economic situation of the subject of the Volga Federal District (explanatory variable) was formed. The model allows you to make a preliminary forecast of the situation on the labor market of the subject of the Volga Federal District.
Socio-Economic Factors of Population Reproduction in Russia and in the Context of Federal Districts
Authors: Gulyaeva T. I. , Takmakova E. V. , Savkin V. I.
Published: May 2023

The purpose of the study. Establishing the specifics of reproduction of the Russian population in the modern conditions of economic development in general and in the context of federal districts.

Materials and methods. In the process of writing the article, the authors used regulatory legal acts of the Government of the Russian Federation, materials of the Federal State Statistics Service, the works of individual scientists and public organizations on the problems of population reproduction. In the course of the work, such statistical research methods as tabular and graphical methods, analysis of indexes of dynamics series were used.

Results. The population of the Russian Federation and the components of its change for 1990-2021, the dynamics of fertility and mortality rates for 1950-2021 were studied, the reasons for the decline in the total fertility rate and the net coefficient of population reproduction, including in the context of federal districts, were considered.

Conclusion. Currently, the population of the Russian Federation has not reached the level of 1990. Fluctuations in the total population growth are mainly caused by fluctuations in migration growth. In conditions of low fertility and high mortality, the migration component is the determining factor of population growth. Since 1992, the natural decline of the population has been established (with the exception of 2013-2015). The amount of migration growth exceeded the natural decline in 2009-2017, which ensured the overall population growth.

The intersection of the curves of the dynamics of the fertility rate and the mortality rate in the Russian Federation was established in 1992 and 2016. From 2012 to 2016 the coefficient of natural growth is approaching zero, and then a downward trend is formed, that is, a decrease in the population.

The main reason for the decline in the birth rate in Russia is the demographic, socio-economic state of society, in which a steady decline in the total fertility rate, demographic aging of the population, and changes in the family structure have been established. Over the past 30 years, there has been a narrowed reproduction of the population in the country, which can be considered as a potential depopulation.

A high variation of the total fertility rate in the context of federal districts of Russia has been established. In the Central Federal District and the North-Western Federal Districts for the period 1990-2021, the total fertility rate did not exceed the average Russian level of this index. Over the past three years (2019-2021), the total fertility rate has been decreasing in the Northwestern, Southern, Volga, and Siberian Federal Districts.

In order to eliminate negative trends in the birth rate in the regions, it is necessary to create jobs, form normal housing conditions, ensure sustainable growth in real income of the population, organize a modern level of healthcare, education, develop a network of preschool institutions, and support families.
Icacinaceae Plant Family: A Recapitulation of the Ethnobotanical, Phytochemical,
Pharmacological, and Biotechnological Aspects
Authors: Hazarika Sangeeta , Borah Pobitra , Deb Pran Kishore , Venugopala Katharigatta N. , Hemalatha Siva
Published: May 2023

Icacinaceae, an Angiospermic family comprising 35 genera and 212 accepted species, including
trees, shrubs, and lianas with pantropical distribution, is one of the most outshining yet least explored plant
families, which despite its vital role as a source of pharmaceuticals and nutraceuticals has received a meagre
amount of attraction from the scientific community. Interestingly, Icacinaceae is considered a potential alternative
resource for camptothecin and its derivatives, which are used in treating ovarian and metastatic colorectal
cancer. However, the concept of this family has been revised many times, but further recognition is still needed.
The prime objective of this review is to compile the available information on this family in order to popularize
it in the scientific community and the general population and promote extensive exploration of these taxa. The
phytochemical preparations or isolated compounds from the Icacinaceae family have been centrally amalgamated
to draw diverse future prospects from this inclusive plant species. The ethnopharmacological activities
and the associated endophytes and cell culture techniques are also depicted. Nevertheless, the methodical evaluation
of the Icacinaceae family is the only means to preserve and corroborate the folkloristic remedial effects
and provide scientific recognition of its potencies before they are lost under the blanket of modernization.
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease
Association Prediction by Integrating Similarities among MiRNAs
and Diseases
Authors: Zeng Xueying , Yang Jialiang , Wang Kun , Xu Junlin , Tian Geng , Li Yang
Published: May 2023

Introduction:

The importance of microRNAs (miRNAs) has been emphasized by an increasing
number of studies, and it is well-known that miRNA dysregulation is associated with a variety
of complex diseases. Revealing the associations between miRNAs and diseases are essential to disease
prevention, diagnosis, and treatment.

Methods:

However, traditional experimental methods in validating the roles of miRNAs in diseases
could be very expensive, labor-intensive and time-consuming. Thus, there is a growing interest in predicting
miRNA-disease associations by computational methods. Though many computational methods
are in this category, their prediction accuracy needs further improvement for downstream experimental
validation. In this study, we proposed a novel model to predict miRNA-disease associations by
low-rank matrix completion (MDAlmc) integrating miRNA functional similarity, disease semantic
similarity, and known miRNA-disease associations. In the 5-fold cross-validation, MDAlmc achieved
an average AUROC of 0.8709 and AUPRC of 0.4172, better than those of previous models.

Results:

Among the case studies of three important human diseases, the top 50 predicted miRNAs of
96% (breast tumors), 98% (lung tumors), and 90% (ovarian tumors) have been confirmed by previous
literatures. And the unconfirmed miRNAs were also validated to be potential disease-associated miRNAs.

Conclusion:

MDAlmc is a valuable computational resource for miRNA–disease association prediction.
Natural Flavonoids as Potential Therapeutics in the Management of
Diabetic Wound: A Review
Authors: Chanu Nongmaithem Randhoni , Gogoi Pal , Barbhuiya Pervej Alom , Dutta Partha Pratim , Pathak Manash Pratim , Sen Saikat
Published: May 2023

Flavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyper-glycaemic environment alters the normal wound-healing process and increases the risk of microbial infection, leading to hospitalization, morbidity, and amputation. Flavonoids are an important class of phytochemicals with excellent antioxidant, anti-inflammatory, antimicrobial, antidiabetic, anti-tumor, and wound healing property. Quercetin, hesperidin, curcumin, kaempferol, apigenin, luteo-lin, morin, etc. have shown their wound healing potential. Flavonoids effectively exhibit antimicro-bial activity, scavenge reactive oxygen species, augment endogenous antioxidants, reduce the ex-pression and synthesis of inflammatory cytokines (i.e. IL-1β, IL-6, TNF-α, NF-κB), inhibit inflam-matory enzymes, enhance anti-inflammatory cytokine (IL-10), enhance insulin section, reduce insu-lin resistance, and control blood glucose level. Several flavonoids like hesperidin, curcumin, quer-cetin, rutin, naringin, and luteolin have shown their potential in managing diabetic wounds. Natural products that maintain glucose haemostatic, exert anti-inflammatory activity, suppress/inhibit mi-crobial growth, modulate cytokines, inhibit matrix metalloproteinase (MMP), stimulate angiogene-sis and extracellular matrix, and modulate growth factor can be considered as a potential therapeutic lead to treat diabetic wound. Flavonoids were found to play a positive role in management of dia-betic wounds by regulating MMP-2, MMP-8, MMP-9, MMP-13, Ras/Raf/ MEK/ERK, PI3K/Akt, and nitric oxide pathways. Therefore, it can be assumed that flavonoids could be potential therapeu-tics to prevent devastating effects of diabetic wounds. This paper focused on the potential role of flavonoids in managing diabetic wounds and discussed their possible mechanism of action.
Computational Insight into the Mechanism of Action of DNA Gyrase
Inhibitors; Revealing a New Mechanism
Authors: Muhammed Muhammed Tilahun , Aki-Yalcin Esin
Published: May 2023

Background:

Discovery of novel antimicrobial agents is in need to deal with antibiotic resistance.
Elucidating the mechanism of action for established drugs contributes to this endeavor. DNA
gyrase is a therapeutic target used in the design and development of new antibacterial agents. Selective
antibacterial gyrase inhibitors are available; however, resistance development against them is a big challenge.
Hence, novel gyrase inhibitors with novel mechanisms are required.

Objective:

The aim of this study is to elucidate mode of action for existing DNA gyrase inhibitors and to
pave the way towards discovery of novel inhibitors.

Methods:

In this study, the mechanism of action for selected DNA gyrase inhibitors available was carried
out through molecular docking and molecular dynamics (MD) simulation. In addition, pharmacophore
analysis, density functional theory (DFT) calculations, and computational pharmacokinetics analysis of the
gyrase inhibitors were performed.

Results:

This study demonstrated that all the DNA gyrase inhibitors investigated, except compound 14, exhibit
their activity by inhibiting gyrase B at a binding pocket. The interaction of the inhibitors at Lys103 was
found to be essential for the binding. The molecular docking and MD simulation results revealed that compound
14 could act by inhibiting gyrase A. A pharmacophore model that consisted of the features that would
help the inhibition effect was generated. The DFT analysis demonstrated 14 had relatively high chemical
stability. Computational pharmacokinetics analysis revealed that most of the explored inhibitors were estimated
to have good drug-like properties. Furthermore, most of the inhibitors were found to be non-mutagenic.

Conclusion:

In this study, mode of action elucidation through molecular docking and MD simulation,
pharmacophore model generation, pharmacokinetic property prediction, and DFT study for selected DNA
gyrase inhibitors were carried out. The outcomes of this study are anticipated to contribute to the design of
novel gyrase inhibitors.
Screening and Identification of Key Genes for Cervical Cancer, Ovarian
Cancer and Endometrial Cancer by Combinational Bioinformatic Analysis
Authors: Pang Feng , Shi Dong , Yuan Lin
Published: May 2023

Introduction:

Cervical cancer, ovarian cancer and endometrial cancer are the top three cancers
in women. With the rapid development of gene chip and high-throughput sequencing technology, it
has been widely used to study genomic functional omics data and identify markers for disease diagnosis
and treatment. At the same time, more and more public databases containing genetic data have appeared.
The result of the bioinformatic analysis can provide a diagnosis of new perspectives on cell
origin and differences.

Methods:

In this paper, three datasets about cervical cancer, ovarian cancer and endometrial cancer from
GEO were used to dig out common DEGs (differentially expressed genes) among cervical cancer/ovarian
cancer/endometrial cancer. DEGs contain 400 up-regulation genes and 157 down-regulation genes.

Results::

The results of GO (gene ontology) functional enrichment analysis show that the BP (biological
process) changes of DEGs are mainly in cell division, mitotic nuclear division, sister chromatid cohesion,
and DNA replication. The CC (cell component) function enrichments of DEGs were mainly in the
nucleoplasm, nucleus, condensed chromosome kinetochore, chromosome, centromeric region. The MF
(molecular function) function enrichments of DEGs were mainly in protein binding. The results of the
KEGG pathway analysis showed that the upregulation DEGs were mainly enriched in retinoblastoma
gene in the cell cycle, cellular senescence, oocyte meiosis, and pathways in cancer, while the downregulation
DEGs enriched in thiamine metabolism, protein processing in endoplasmic reticulum. Similarly,
the function of the most significant module was enriched in cell division, condensed chromosome kinetochore,
and microtubule motor activity.

Conclusion:

In the result, 4 of the top 10 hub genes (CCNA2, CCNB1, CDC6 and CDK1) will provide
help for future biomedical experimental research.
A Double-Emulsion Method for the Fabrication of PLA Single-Hole Hollow
Particles
Authors: Li Yanan , Zhang Liyun , Tian Rui , Pranantyo Dicky , Chen Linfeng , Xia Fan
Published: May 2023

Background:

Polymeric hollow particles with a single-hole structure have attracted
broad interest due to their combined advantages of a hollow cavity and an opening hole in the
shell.

Aim:

In the past decades, much progress has been made in the fabrication of such particles with
various strategies. However, there is a lack of research on the easy fabrication of biodegradable
polylactide (PLA) single hole particles (PLA SHHPs).

Methods:

In this work, we reported a simple double emulsion method for the fabrication of PLA
SHHPs. The W/O/W double emulsion was formed by homogenizing PLA chloroform and brilliant
blue G (BBG) solution. Scanning electron microscopy and confocal laser scanning microscopy
were used for the characterization. It was found that the concentrations of PLA chloroform and
BBG solution both had a significant influence on the emulsion structure.

Result:

PLA SHHPs with a percentage >85% were obtained from the emulsion composed of
PLA chloroform (10.0 w%) and BBG solution (4 mM). The particle formation mechanism was
also proposed based on the result of the low interfacial tension between PLA chloroform/BBG
solution.

Conclusion:

The results may inspire new development of PLA particles with unique structures,
which are promising to be used in drug delivery, catalysis, microreaction and micromotors.
Lanting House Preservation Based on River Culture In Sasirangan Village, Banjarmasin
Authors: Pertiwi Aula Sekar Arum , Nugroho Agung Murti
Published: April 2023

The shift in time has brought about changes that clearly leave the cultural identity of the archipelago. Sasirangan Village is one of the villages located in the middle of Banjarmasin City. This village still has a strong atmosphere, especially in the diversity of architecture in the area. River culture is still visible in this village, both for daily needs and also land for housing, namely Rumah Lanting. There are 3 Lanting houses in Sasirangan Village. The lack of a number of Lanting Houses left at this time raises a concern that there is a threat of extinction from cultural heritage. In this case, it is necessary to have a study of the architectural concept of the Lanting House to determine the right steps in preserving the Lanting House. The results of this study found that the right effort to preserve the Lanting House in Sasirangan Village was a revitalization effort that did not require material replacement and developed it as a Sasirangan gallery or souvenir shop that supports local wisdom and the identity of Sasirangan Village.
PERBANDINGAN BERBAGAI METODE PENGUJIAN AKTIVITAS ANTIOKSIDAN (DPPH, ABTS DAN FRAP) PADA TEH HITAM (Camellia sinensis)
Authors: Theafelicia Zerlinda , Narsito Wulan Siti
Published: May 2023

Senyawa antioksidan berperan dalam menghambat atau menunda reaksi oksidasi molekul dengan cara memperlambat proses inisiasi atau propagasi reaksi oksidasi berantai. Hasil pengujian aktivitas antioksidan dapat bervariasi karena perbedaan struktur kimiawi antioksidan, sumber radikal bebas, dan sifat fisikokimia dari sampel yang diuji. Senyawa yang mengandung radikal bebas memiliki satu atau lebih elektron yang tidak berpasangan dan bersifat reaktif sehingga dapat merusak sel dan jaringan bila terakumulasi dalam tubuh manusia. Terdapat antioksidan alami dan sintetis yang berfungsi untuk menghambat reaksi oksidasi dan mencegah terbentuknya radikal bebas. Namun, perlu diperhatikan bahwa antioksidan sintetis dapat memodifikasi senyawa menjadi karsinogenik. Oleh karena itu, eksplorasi antioksidan alami dan pengujian aktivitas antioksidannya penting dilakukan. Salah satunya adalah pengujian aktivitas antioksidan teh hitam (Camellia sinensis). Teh merupakan salah satu minuman yang paling populer di dunia dan merupakan tanaman yang banyak ditemukan di daerah pegunungan Asia. Teh diketahui memiliki manfaat kesehatan karena mengandung polifenol yang merupakan antioksidan alami. Antioksidan polifenol berperan dalam melawan radikal bebas yang berbahaya bagi tubuh. Penentuan aktivitas antioksidan dilakukan dengan uji penangkapan radikal DPPH (2.2-difenill-1-pikrilhidrazil), ABTS (3-ethyl-benzothiazoline-6-sulfonic acid) dan FRAP (Ferric Reducing Antioxidant Power). Ketiga metode uji antioksidan berbeda dalam mekanisme reaksinya. Hasil pengujian antioksidan pada teh hitam dengan metode DPPH sebesar 208.83 mgTE/g, ABTS sebesar 217.83 mgTE/g dan FRAP sebesar 42.15 mgTE/g, dimana TE adalah Trolox Ekuivalen.
El papel de los militares en la política exterior colombiana: estudio de caso
Authors: Monroy-Hernandez Maria Catalina , Fonseca-Medina María Paula
Published: May 2023

Este artículo investiga el proceso de toma de decisiones durante la crisis de la corbeta ARC Caldas en el golfo de Venezuela en 1987, con el fin de analizar el papel de los militares en la política exterior colombiana. Para ello, se desarrolla un análisis cualitativo sustentado en la revisión de fuentes primarias, artículos académicos, archivos históricos, análisis de prensa y entrevistas. Con base en los conceptos de diplomacia de defensa y polythink, se evidencian las divergencias en la mesa entre políticos/diplomáticos y militares, y sus efectos en el proceso de toma de decisión. Se evidencia la falta de consenso en la mesa, la inclinación diplomática del presidente Barco, pero también la importancia de los militares para una decisión que considere todos los posibles cursos de acción y sus consecuencias.
The Spanish Army in Security Force Assistance
Authors: López-Rodríguez Guillermo
Published: May 2023

This article analyses the lessons learned by the Spanish Army in the Security Force Assistance (SFA) Operation in Iraq between 2015 and 2020. The research uses primary data from 22 personal interviews conducted with Spanish officers and NCOs, as well as secondary data sourced from a database containing the Spanish Army’s online mission register. The results identify the scenarios and activities performed in SFA operations, as well as the main lessons learned by the Spanish Army in Iraq. The two main lessons are the prevention of internal attacks and the relevance of awareness of cultural dimensions to improve training processes. Conclusions can be extrapolated to other European armies, providing policy recommendations for training local forces in SFA operations.