bluuebunny/crossref_metadata_2025 huggingface dataset:
Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer
Authors: Gu Jianyou , Huang Wenjie , Wang Xianxing , Zhang Junfeng , Tao Tian , Zheng Yao , Liu Songsong , Yang Jiali , Chen Zhe-Sheng , Cai Chao-Yun , Li Jinsui , Wang Huaizhi , Fan Yingfang
Published: May 2022

Background

Although gemcitabine has been considered as the first-line drug for advanced pancreatic cancer (PC), development of resistance to gemcitabine severely limits the effectiveness of this chemotherapy, and the underlying mechanism of gemcitabine resistance remains unclear. Various factors, such as ATP binding cassette (ABC) transporters, microRNAs and their downstream signaling pathways are included in chemoresistance to gemcitabine. This study investigated the potential mechanisms of microRNAs and ABC transporters related signaling pathways for PC resistance to gemcitabine both in vivo and in vitro.

Methods

Immunohistochemistry and Western blotting were applied to detect the expression of ABC transporters. Molecular docking analysis was performed to explore whether gemcitabine interacted with ABC transporters. Gain-of-function and loss-of-function analyses were performed to investigate the functions of hsa-miR-3178 in vitro and in vivo. Bioinformatics analysis, Western blotting and dual-luciferase reporter assay were used to confirm the downstream regulatory mechanisms of hsa-miR-3178.

Results

We found that P-gp, BCRP and MRP1 were highly expressed in gemcitabine-resistant PC tissues and cells. Molecular docking analysis revealed that gemcitabine can bind to the ABC transporters. Hsa-miR-3178 was upregulated in gemcitabine resistance PANC-1 cells as compared to its parental PANC-1 cells. Moreover, we found that hsa-miR-3178 promoted gemcitabine resistance in PC cells. These results were also verified by animal experiments. RhoB was down-regulated in gemcitabine-resistant PC cells and it was a downstream target of hsa-miR-3178. Kaplan–Meier survival curve showed that lower RhoB expression was significantly associated with poor overall survival in PC patients. Rescue assays demonstrated that RhoB could reverse hsa-miR-3178-mediated gemcitabine resistance. Interestingly, hsa-miR-3178 promoted gemcitabine resistance in PC by activating the PI3K/Akt pathway-mediated upregulation of ABC transporters.

Conclusions

Our results indicate that hsa-miR-3178 promotes gemcitabine resistance via RhoB/PI3K/Akt signaling pathway-mediated upregulation of ABC transporters. These findings suggest that hsa-miR-3178 could be a novel therapeutic target for overcoming gemcitabine resistance in PC.
FMRP ligand circZNF609 destabilizes RAC1 mRNA to reduce metastasis in acral melanoma and cutaneous melanoma
Authors: Shang Qingfeng , Du Haizhen , Wu Xiaowen , Guo Qian , Zhang Fenghao , Gong Ziqi , Jiao Tao , Guo Jun , Kong Yan
Published: May 2022

Background

Melanoma is a type of malignant tumor with high aggressiveness and poor prognosis. At present, metastasis of melanoma is still an important cause of death in melanoma patients. However, the potential functions and molecular mechanisms of most circular RNAs (circRNAs) in melanoma metastasis remain unknown.

Methods

circRNAs dysregulated in melanoma cell subgroups with different metastatic abilities according to a screening model based on repeated Transwell assays were identified with a circRNA array. The expression and prognostic significance of circZNF609 in skin cutaneous melanoma and acral melanoma cells and tissues were determined by qRT–PCR, nucleoplasmic separation assays and fluorescence in situ hybridization. In vitro wound healing, Transwell and 3D invasion assays were used to analyse melanoma cell metastasis ability. Tail vein injection and intrasplenic injection were used to study in vivo lung metastasis and liver metastasis, respectively. The mechanism of circZNF609 was further evaluated via RNA immunoprecipitation, RNA pull-down, silver staining, and immunofluorescence colocalization assays.

Results

circZNF609 was stably expressed at low levels in melanoma tissues and cells and was negatively correlated with Breslow depth, clinical stage and prognosis of melanoma patients. circZNF609 inhibited metastasis of acral and cutaneous melanoma in vivo and in vitro. Mechanistically, circZNF609 promoted the binding of FMRP protein and RAC1 mRNA, thereby enhancing the inhibitory effect of FMRP protein on the stability of RAC1 mRNA and ultimately inhibiting melanoma metastasis.

Conclusions

Our findings revealed that circZNF609 plays a vital role in the metastasis of acral and cutaneous melanoma through the circRNF609-FMRP-RAC1 axis and indicated that circZNF609 regulates the stability of RAC1 mRNA by combining with FMRP, which might provide insight into melanoma pathogenesis and a new potential target for treatment of melanoma.
Factors associated with age of diagnosis of autism spectrum disorder among children in Saudi Arabia: new insights from a cross-sectional study
Authors: Alnemary Fahad M. , Alnemary Faisal M. , Simon-Cereijido Gabriela , Aldhalaan Hesham M. , Hernandez Anthony , Alyahya Ahmed , Alenezi Shuliweeh
Published: May 2022

Objectives

Research examining the age of diagnosis of autism spectrum disorder (ASD) and its influencing factors mostly originate from developed Western countries, providing little to no systematic information about the understanding and management of ASD in the rest of the world. The present exploratory study examined the influence of child and family characteristics on the age of ASD diagnosis in Saudi Arabia.

Results

The median age at diagnosis was 3.0 years and was associated with some child and family characteristics. A 1 year increase in child’s age was associated with a 0.1 year increase in age of diagnosis (95% CI 0.05, 0.12). Children who did not respond to their name were diagnosed 0.3 years earlier than other children (95% CI − 0.60, − 0.05), and engaging in challenging behavior was associated with a 0.5 year increase in age of diagnosis (95% CI 0.20, 0.81). A lack of comorbidity was associated with a 0.6 year increase in the age of diagnosis compared to the diagnosis age of children with comorbidity (95% CI 0.13, 1.01). Finally, those residing outside of Saudi Arabia were diagnosed with ASD 0.9 years earlier than those residing in Saudi Arabia (95% CI − 0.171, − 0.11).
Face image synthesis from facial parts
Authors: Sun Qiushi , Guo Jingtao , Liu Yi
Published: May 2022

Recently, inspired by the growing power of deep convolutional neural networks (CNNs) and generative adversarial networks (GANs), facial image editing has received increasing attention and has produced a series of wide-ranging applications. In this paper, we propose a new and effective approach to a challenging task: synthesizing face images based on key facial parts. The proposed approach is a novel deep generative network that can automatically align facial parts with the precise positions in a face image and then output an entire facial image conditioned on the well-aligned parts. Specifically, three loss functions are introduced in this approach, which are the key to making the synthesized realistic facial image: a reconstruction loss to generate image content in an unknown region, a perceptual loss to enhance the network's ability to model high-level semantic structures and an adversarial loss to ensure that the synthesized images are visually realistic. In this approach, the three components cooperate well to form an effective framework for parts-based high-quality facial image synthesis. Finally, extensive experiments demonstrate the superior performance of this method to existing solutions.
Effect of High-intensity Training and Probiotics on Gut Microbiota Diversity in Competitive Swimmers: Randomized Controlled Trial
Authors: Bielik Viktor , Hric Ivan , Ugrayová Simona , Kubáňová Libuša , Putala Matúš , Grznár Ľuboš , Penesová Adela , Havranová Andrea , Šardzíková Sára , Grendar Marián , Baranovičová Eva , Šoltys Katarína , Kolisek Martin
Published: May 2022

Background

Physical exercise has favorable effects on the structure of gut microbiota and metabolite production in sedentary subjects. However, little is known whether adjustments in an athletic program impact overall changes of gut microbiome in high-level athletes. We therefore characterized fecal microbiota and serum metabolites in response to a 7-week, high-intensity training program and consumption of probiotic Bryndza cheese.

Methods

Fecal and blood samples and training logs were collected from young competitive male (n = 17) and female (n = 7) swimmers. Fecal microbiota were categorized using specific primers targeting the V1–V3 region of 16S rDNA, and serum metabolites were characterized by NMR-spectroscopic analysis and by multivariate statistical analysis, Spearman rank correlations, and Random Forest models.

Results

We found higher α-diversity, represented by the Shannon index value (HITB-pre 5.9 [± 0.4]; HITB-post 6.4 [± 0.4], p = 0.007), (HIT-pre 5.5 [± 0.6]; HIT-post 5.9 [± 0.6], p = 0.015), after the end of the training program in both groups independently of Bryndza cheese consumption. However, Lactococcus spp. increased in both groups, with a higher effect in the Bryndza cheese consumers (HITB-pre 0.0021 [± 0.0055]; HITB-post 0.0268 [± 0.0542], p = 0.008), (HIT-pre 0.0014 [± 0.0036]; HIT-post 0.0068 [± 0.0095], p = 0.046). Concomitant with the increase of high-intensity exercise and the resulting increase of anaerobic metabolism proportion, pyruvate (p[HITB] = 0.003; p[HIT] = 0.000) and lactate (p[HITB] = 0.000; p[HIT] = 0.030) increased, whereas acetate (p[HITB] = 0.000; p[HIT] = 0.002) and butyrate (p[HITB] = 0.091; p[HIT] = 0.019) significantly decreased.

Conclusions

Together, these data demonstrate a significant effect of high-intensity training (HIT) on both gut microbiota composition and serum energy metabolites. Thus, the combination of intensive athletic training with the use of natural probiotics is beneficial because of the increase in the relative abundance of lactic acid bacteria.
Systems Analysis and Improvement Approach to optimize the pediatric and adolescent HIV Cascade (SAIA-PEDS): a pilot study
Authors: Wagner Anjuli D. , Augusto Orvalho , Njuguna Irene N. , Gaitho Douglas , Mburu Nancy , Oluoch Geoffrey , Carimo Naziat , Mwaura Peter , Cherutich Peter , Oyiengo Laura , Gimbel Sarah , John-Stewart Grace C. , Nduati Ruth , Sherr Kenneth
Published: May 2022

Introduction

Children and adolescents lag behind adults in achieving UNAIDS 95-95-95 targets for HIV testing, treatment, and viral suppression. The Systems Analysis and Improvement Approach (SAIA) is a multi-component implementation strategy previously shown to improve the HIV care cascade for pregnant women and infants. SAIA merits adaptation and testing to reduce gaps in the pediatric and adolescent HIV cascade.

Methods

We adapted the SAIA strategy components to be applicable to the pediatric and adolescent HIV care cascade (SAIA-PEDS) in Nairobi and western Kenya. We tested whether this SAIA-PEDS strategy improved HIV testing, linkage to care, antiretroviral treatment (ART), viral load (VL) testing, and viral load suppression for children and adolescents ages 0–24 years at 5 facilities. We conducted a pre-post analysis with 6 months pre- and 6 months post-implementation strategy (coupled with an interrupted time series sensitivity analysis) using abstracted routine program data to determine changes attributable to SAIA-PEDS.

Results

Baseline levels of HIV testing and care cascade indicators were heterogeneous between facilities. Per facility, the monthly average number of children/adolescents attending outpatient and inpatient services eligible for HIV testing was 842; on average, 253 received HIV testing services, 6 tested positive, 6 were linked to care, and 5 initiated ART. Among those on treatment at the facility, an average of 15 had a VL sample taken and 13 had suppressed VL results returned.

Following the SAIA-PEDS training and mentorship, there was no substantial or significant change in the ratio of HIV testing (RR: 0.803 [95% CI: 0.420, 1.532]) and linkage to care (RR: 0.831 [95% CI: 0.546, 1.266]). The ratio of ART initiation increased substantially and trended towards significance (RR: 1.412 [95% CI: 0.999, 1.996]). There were significant and substantial improvements in the ratio of VL tests ordered (RR: 1.939 [95% CI: 1.230, 3.055]) but no substantial or significant change in the ratio of VL results suppressed (RR: 0.851 [95% CI: 0.554, 1.306]).

Conclusions

The piloted SAIA-PEDS implementation strategy was associated with increases in health system performance for indicators later in the HIV care cascade, but not for HIV testing and treatment indicators. This strategy merits further rigorous testing for effectiveness and sustainment.
Barbed suture pharyngoplasty in velopharyngeal complete concentric collapse: a multicentric study
Authors: Castillo-Farias Felipe , Carrasco-Llatas Marina , Bosco Gabriela , Rinaldi Vittorio , Baptista-Jardín Peter Michael , Cammaroto Giovanni , Alkan Uri , Muñoz-Fernandez Noelia , Rosel Pablo , Bachelet Cristian , Casale Manuele , Moffa Antonio , Plaza-Mayor Guillermo , Perez-Martin Nuria , Vicini Claudio
Published: May 2022

Background

Studies have shown that complete concentric circular collapse (CCC) at the velum is a frequent finding in drug-induced sleep endoscopy, implying a worse prognosis for surgical outcomes in the treatment of obstructive sleep apnea syndrome (OSAS). Our group evaluated the results of pharyngoplasties with barbed sutures for this indication. We selected 48 patients with OSAS and CCC who underwent pharyngoplasty with barbed sutures in 8 tertiary centers. The outcome results were measured by polygraphy or polysomnography and Epworth Symptoms Scale (ESS) at least 6 months after surgery.

Results

Apnea Hypopnea Index (AHI) improved from 34.9/h [21.2] to 12.7/h [10.6]. The success rate according to Sher’s criteria was 86.7%, the cure rate was 23.9%, and an AHI < 10 occurred in 42.2% of the cases. The oxygen desaturation index improved from 32.5/h [29.9] to 12.5/h SD [11.6], and the ESS improved from 10.2 [5.2] to 6 [3.5].

Conclusions

Pharyngoplasty with barbed sutures seems to be a good alternative for patients with OSAS and CCC findings in drug-induced sleep endoscopy.
Thrombocytopenic patients with hematological malignancy who underwent fiberoptic bronchoscopy are they really under a significant hemorrhagic risk?
Authors: Yıldırım Fatih , Özkalemkaş Fahir , Ursavaş Ahmet
Published: May 2022

Background

Fiberoptic bronchoscopy (FOB) is a very important procedure in hematology clinics. Clinicians often worry about thrombocytopenia before performing FOB because hemorrhagic complications may occur during and after FOB. We have planned a retrospective study about hemorrhagic complications in thrombocytopenic patients who underwent FOB and treated for hematological malignancy. In this study, we have analyzed hemorrhagic complications, which are related to thrombocytopenia, in 114 adult patients who have hematologic malignancy and underwent FOB between January 1, 2005 and October 20, 2015. The platelet counts of all the patients were below 100 × 109/L.

Results

The complications related to FOB were observed in 4 (3.5%) out of 114 patient. Three out of 4 the complications were related to hemorrhage. One out of these 3 patients who occured hemorrhage was in “no bleeding group” according to BTS classification. The other 1 out of these 3 patients was in “mild bleeding” group. No bleeding was observed during FOB in the third patient. Hemoptysis was observed after FOB in the third patient, it was not required replacement and hemoptysis regressed spontaneously.

In this study, we categorized all the patients into three groups. The first group was comprised of 32 patients whose platelet counts were between 0 and 30 × 109/L. The second group was comprised of 47 patients whose platelets counts were between 30 and 50 × 109/L and lastly, the third group was comprised of 35 patients whose platelets counts were between 50 and 100 × 109/L. When we compared the groups to each other, there was no significant difference between these three groups in regards to occurrence of hemorrhagic complications. We observed that there was no significant relationship between thrombocytopenia level and risk of hemorrhagic complications in thrombocytopenic patients who underwent FOB.

Conclusions

In conclusion, this study demonstrated that FOB is safe procedures in thrombocytopenic patients if it is performed in multidisciplinary centers by experienced pulmonologists.
Slow and Steady Wins the Race: 25 Years Developing the GLP-1 Receptor as an Effective Target for Weight Loss
Authors: Kumar Nitya , D’Alessio David A
Published: May 2022

Recent evidence from clinical trials supports the efficacy and tolerability of glucagon-like peptide 1 (GLP-1) receptor agonists as useful agents for weight loss. Although originally developed as glucose lowering agents for people with type 2 diabetes, progress in research over the last 3 decades has demonstrated that GLP-1 receptor agonists act in the central nervous system to reduce food intake. This minireview summarizes key aspects of GLP-1 biology and the clinical studies supporting the utility of the GLP-1 receptor signaling system as a therapeutic target for weight loss.
“Law Enough to Set You Free”: Contract, Community, and Consent in the Comedies of George Farquhar
Authors: Feldman Alex
Published: May 2022

From his first play, Love and a Bottle (1698), to the masterpiece that crowned his career, The Beaux’ Stratagem (1707), George Farquhar's oeuvre is traversed by legal motifs and legal scenarios, from satirical attacks upon the judiciary, to serious engagements with the law of contract, in contexts as varied as military impressment and spousal neglect. The period that followed the accession of William and Mary, in 1688, and the Bill of Rights to which they assented in 1689, is commonly regarded as being governed by contractual relationships between rational individuals, entering into reciprocal obligations, pursuing their interests, while recognizing their natural rights. But Farquhar's comedies exhibit a conspicuous distrust of the legal profession, and of contract as a means of ensuring ethical solutions either to domestic or political conflicts. Farquhar's engagements with the law, in general, and the law of contracts, in particular, reorient drama away from the rights of the liberal subject, autonomously imagined, toward renewed conceptions of the social good, and the ethics of the community, replacing regulatory frameworks with emancipatory dispensations, in the benevolent comic spirit that characterizes his works.
Lovelace's “Gloomy Scheme of Death”: Suffering, Dueling, and Suicide in Richardson's Clarissa
Authors: Sulich Rachel
Published: May 2022

This article uses Samuel Richardson's Clarissa (1747–48) as a case study in order to expose the relationship between dueling and suicide in eighteenth-century literature and culture. By examining the novel alongside contemporary documents concerning dueling, I make the case that Lovelace's fatal duel with Morden is a covert form of self-destruction, one that allows him to disguise and ultimately escape his sufferings while maintaining his masculine honor and reputation. While many critics have focused on Clarissa's suicide in Richardson's novel, few have considered the nature of Lovelace's own self-willed death at length. The following consideration of Lovelace's “gloomy scheme of death” reveals the violence necessary for performances of masculinity in the early to mid-eighteenth century and suggests that the duel is at the heart at such efforts at self-display.
Unsettled Borders
Authors: Schaeffer Felicity Amaya
Published: May 2022

In Unsettled Borders Felicity Amaya Schaeffer examines the ongoing settler colonial war over the US-Mexico border from the perspective of Apache, Tohono O’odham, and Maya who fight to protect their sacred land. Schaeffer traces the scientific and technological development of militarized border surveillance across time and space from Spanish colonial lookout points in Arizona and Mexico to the Indian wars, when the US cavalry hired Native scouts to track Apache fleeing into Mexico, to the occupation of the Tohono O’odham reservation and the recent launch of robotic bee swarms. Labeled “Optics Valley,” Arizona builds on a global history of violent dispossession and containment of Native peoples and migrants by branding itself as a profitable hub for surveillance. Schaeffer reverses the logic of borders by turning to Indigenous sacredsciences: ancestral land-based practices that are critical to reversing the ecological and social violence of surveillance, extraction, and occupation.
THE ORIGIN OF THE STATE IN THE SOCIO-PHILOSOPHICAL PARADIGM K. LEONTIEV
Authors: MARKOV R.S. , BURTSEVA E.A. , SHURUPOVA E.I.
Published: May 2022

The article deals with the philosophical understanding of the social phenomenon of the origin of the state, presented in the works of the pre-revolutionary Russian thinker and conservative publicist K Leontiev. Arguments both confirming and refuting the truth of the proposed concept are studied. It is proved that the Leontiev paradigm is an original interpretation of the organic theory of the origin of the state, which is supported by examples from the natural world and world history.
DEVELOPMENT OF AN OPTIMIZATION MODEL OF A SYSTEM FOR PROVIDING DISTRIBUTED TRANSPORT SERVICES
Authors: LVOVICH Ya.Ye. , PREOBRAZHENSKIY A.P. , PREOBRAZHENSKIY Yu.P.
Published: May 2022

The paper deals with the problem associated with the optimization of resources in transport systems. An illustration of the block diagram of the system for providing transport services is given.
ABOUT THE ROLE OF THE FORWARDING COMPANY IN INCREASING THE ECONOMIC EFFICIENCY OF FOREIGN TRADE TRANSACTIONS OF CUSTOMERS (SELLERS AND BUYERS OF GOODS)
Authors: MELNIKOV A.R. , MELNIKOVA I.P , SHISHKAREVA N.V.
Published: May 2022

As part of the study and analysis of domestic and foreign practice of foreign trade in goods and freight forwarding, a characteristic of a conditional forwarding company is given that is able to provide a cargo owner customer with a reduction in costs in the transport component in the price of the customer’s goods. The object of the study is: the market of trade, transport operations and freight forwarding services. The objectives of the research, based on the methods of analysis and synthesis, are: research and analysis of the current state of the issue of interaction between the customer and the forwarder in the freight forwarding market.
ON THE PROBLEM OF SELF-ASSESSMENT OF MANAGERIAL COMPETENCIES OF MODERN TECHNICAL MANAGERS
Authors: UDAL'TSOVA M.O.
Published: May 2022

This article reveals the features of self-assessment of managerial competencies of technical managers by comparing data with the assessments of experts and potential managers: the importance of self-assessment as a structural part of professional self-awareness is revealed, expert assessment of managerial competencies of managers is studied, differences in self-assessment of current and potential managers are noted, conclusions describing the dependencies of self-assessment of managers and experts are presented.
PRACTICE-ORIENTED NATURE OF TEACHING A FOREIGN LANGUAGE AT THE UNIVERSITY THROUGH THE «FLIPPED CLASS» METHOD
Authors: GORSHKOVA K.V. , LUBOZHEVA L.N.
Published: May 2022

This study presents the study of the practise-oriented nature of teaching of a foreign language at a university. The work reveals the concept of “practice-oriented learning” and the principles of this approach. The study demonstrates the “Flipped class” method as the method that has the main characteristics of a student-centered approach to learning. Besides the results of the application of this method by foreign researchers are illustrated in this work. The main purpose of the article is to attract the interest of Russian researchers to the application of the “Flipped class” method in universities.
ON TEACHING THE BASICS OF ACADEMIC COMMUNICATION IN A NEW FORMAT
Authors: BARYSHNIKOV M.P. , BARYSHNIKOVA A.M.
Published: May 2022

The article is devoted to the problem of teaching academic communication to future engineers. The authors consider the possibilities of teaching the “Basics of Academic Communication” to future engineers in new formats in order to form competencies listed in the syllabus. It is essential to use not only traditional teaching methods, but also innovative, interactive teaching methods, to use tasks in new formats aimed at developing students’ skills to shape their own knowledge, working in groups. The authors describe the system of work that develops the ability to communicate effectively and present the results of research and project activities at various public events, not only in Russian, but also in a foreign language.
TERMINAL VALUES OF FEMALE AND MALE STUDENTS OF AGRARIAN VOCATIONAL TRAINING
Authors: KHARLOVA E.V. , GORDIENKO O.N. , BARINOVA N.G.
Published: May 2022

The purpose of the research presented in this article was to study the terminal values of female and male students of agricultural vocational training. The novelty of the study is to identify the expression of each of the eight terminal values (determined by the methodology of I. G. Senin), their representation in various five spheres of life of students of different faculties of the Agrarian University. The results of the study show that there are differences in the severity of terminal values and the value of life spheres among female and male students.
„A ci, którzy chcą się bogacić”. Analiza lingwistyczno-teologiczna 1 Tm 6,9.
Authors: Tomczyk Dominik Tomasz
Published: May 2022

Autor artykułu przedstawia analizę lingwistyczno-teologiczną tekstu 1 Tm 6,9, który jest parenetycznym pouczeniem o możliwych niebezpieczeństwach czekających tych, którzy chcą się bogacić. Poprzestawanie na tym, co się już posiada w perspektywie życia wiecznego jest ważniejsze od pomnażania swoich majętności.W 1 Tm 6,9 wyodrębnić możemy dwa główne etapy niebezpieczeństw: „wpadanie” i „zatapianie”. W etapie „wpadania” można wyodrębnić trzy podetapy (próba, sidła,  pragnienia), zaś w etapie „zatapiania” dwa podetapy (zguba, zatracenie). Niepohamowane pragnienie bogacenia się może w konsekwencji doprowadzić nawet do wiecznego potępienia.
Frühmittelalterliche päpstliche Grabinschriften in der Basilika von St. Peter in Rom
Authors: Baltolu Ramona
Published: May 2022

Ottavio Bucarelli präsentiert eine sehr akribische Zusammenstellung von Grabinschriften der Päpste vom 5. bis 12. Jahrhundert, die in Alt-St. Peter in Rom bestattet wurden. Er trägt dabei auch Texte von heute verlorenen Objekten zusammen, rekonstruiert die ursprüngliche Begräbnissituation und bietet sowohl in der Einleitung als auch im Katalog eine ausführliche Textanalyse. Die Quellentexte lassen sich über ausführliche Register erschließen.
Rare Case of Renal Limited Dual Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Double Trouble!
Authors: Elias John Elenjickal , Roy Sanjeet , Sundar Raj Mani Selvin , Joseph Eapen Jeethu , Mishra Utkarash , Varughese Santosh
Published: May 2022

Dual anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) characterized by the presence of both anti-proteinase-3 (PR3-ANCA) and anti-myeloperoxidase (MPO-ANCA) antibodies is a rare clinical entity. Only few cases have been reported previously, most of which were associated with infections, drugs, autoimmune diseases and malignancies. Herein, we describe a young woman who presented with rapidly progressive glomerulonephritis with hypocomplementemia and markedly elevated anti-PR3 and anti-MPO titres. Meticulous work-up ruled out all possible secondary causes. Renal biopsy showed the presence of focal fibrocellular crescents with focal mesangial hypercellularity. Immunofluorescence and electron microscopy showed pauci-immune deposits. The patient was treated with an induction regimen comprising oral prednisolone and cyclophosphamide. She attained both clinical and serological remission at 3 months and is currently on an azathioprine-based maintenance regimen. We have extensively reviewed all previous cases of dual AAV and have formulated an approach to diagnose and treat this rare entity.
FASES DA INTERAÇÃO NA LEITURA COMPARTILHADA ENTRE PROFESSORESE ALUNOS COM BASE NA ANÁLISE DAS FUNÇÕES DA FALA
Authors: Marques João Baptista Favero , Fuzer Cristiane , Gerhardt Carla Carine
Published: May 2022

O objetivo da pesquisa é identificar fases da interação entre professores e alunos do ensino fundamental durante execução de atividades de leitura detalhada e analisar seu papel na negociação de significados no discurso pedagógico. As atividades baseiam-se na Pedagogia de Gêneros da Escola de Sydney, cuja metodologia de ensino está desenhada como Ciclo de Ensino e Aprendizagem (CEA) (ROSE; MARTIN, 2012) e cujos pressupostos teóricos partem da Linguística Sistêmico-Funcional (LSF). O corpus é constituído por sequências de falas de dois mediadores e de uma turma de alunos do 6º e 7º ano, durante uma ação de extensão do projeto Ateliê de Textos (FUZER, 2016) numa escola pública, em Santa Maria, RS, em 2019. As falas foram gravadas em vídeo, transcritas e analisadas conforme os procedimentos da pesquisa de Gerhardt (2018). Foram analisadas as ocorrências de funções da fala a partir de realizações léxico-gramaticais e respectivas reações (HALLIDAY; MATTHIESSEN, 2014) e identificadas fases da interação na leitura compartilhada (ROSE; MARTIN, 2012). Os resultados evidenciaram a Pergunta como a função da fala mais utilizada pelos participantes da interação, seguida de Comando, usado, principalmente, pelos docentes por meio de metáfora gramatical. As fases preparação e elaboração, utilizadas pelos professores, propiciou que os alunos respondessem adequadamente ao que foi solicitado, embora o uso da fase elaboração não tenha ocorrido pelos discentes. Verifica-se, assim, a importância do planejamento prévio pelos professores do modo de conduzir as Perguntas nas aulas, a fim de que os alunos utilizem a elaboração durante a leitura compartilhada.
ESSA CONSTRUÇÃO SOFREU MÓ MUDANÇA DE LÁ PRA CÁ: POSSÍVEL TRAJETÓRIA EVOLUTIVA DA CONSTRUÇÃO [MÓX]
Authors: Freitas Jr Roberto , Silva Érica Cristina , Barbosa Kleveland Cristian
Published: May 2022

O artigo em tela apresenta o recorte de uma pesquisa de mestrado em desenvolvimento e discute a possível construcionalização da Construção de Informalidade e Intensificação [MóX], vulgo construção [MóX], no Português do Brasil. À luz da Linguística Funcional Centrada no Uso (GOLDBERG, 2006; CROFT, 2001; HILPERT, 2014; PEREK, 2015; BYBEE, 2008 e 2010; TRAUGOTT e TROUSDALE, 2013), tendo como aporte teórico a Gramática de Construções Baseada no Uso, o presente trabalho tem como objetivo mapear, analisar e descrever sincronicamente os contextos de uso de expressões como [Mó saudade], [Mó legal], [Mó relembrando], [Mó mal] no PB na tentativa de compreender como se deu esse possível processo de construcionalização. Sob a perspectiva construcional, algumas propriedades do pareamento forma e função serão observadas, visto serem esses os critérios que determinam e definem o novo nó na rede construcional.  Para robustecer a ideia de que a construção [MóX] possa ser um exemplo de mudança, tal qual defendido pelo modelo de construcionalização, processos cognitivos de domínio geral como chunking e memória enriquecida serão abordados. Para situar o estudo e comprovar a criação desse novo nó, foi necessário remontar ao latim, ao galego-português e ao português do século XX e XXI, sendo também realizado um mapeamento de dados extraídos do Twitter. Os dados foram usados para analisar historicamente a evolução e transformação da construção.
Gramática de Construções Cognitiva e ensino de língua estrangeira: uma proposta para o ensino da alternância dativa do inglês
Authors: Santos Maria Clara Pimenta Camelo dos , Pinheiro Diogo
Published: May 2022

Este artigo contribui com a aplicação dos estudos teóricos da Gramática de Construções Cognitiva (GCC) – uma das variantes funcionalistas da Gramática de Construções – ao ensino de língua estrangeira. Para isso, o artigo relata um experimento no qual foi avaliada a viabilidade de se combinar, no ensino da alternância dativa do inglês, os mecanismos analíticos da GCC às premissas teóricas que caracterizam abordagens comunicativas de ensino de língua estrangeira. Especificamente, o experimento buscou comparar a eficácia de dois tipos de abordagens didáticas da alternância dativa: de um lado, uma abordagem tradicional (isto é, monológica e expositiva) associada a um tratamento construcionista do tópico gramatical; de outra, uma abordagem comunicativa (isto é, fortemente dialógica e centrada no aprendiz), igualmente associada a um tratamento baseado na GCC. Os resultados (i) sugerem que a adoção de uma perspectiva cognitivista e construcionista é perfeitamente compatível com o recurso a uma abordagem comunicativa de ensino de língua e (ii) fornecem indícios de que essa combinação pode ser particularmente relevante quando se trata de produzir melhorias no desempenho dos estudantes em tarefas comunicativas mais naturalísticas.
Vania Dutra e Sarah Cabral entrevistam Carlos Alberto Marques Oliveira
Authors: Gouveia Carlos A. M. , Dutra Vania L. R. , Cabral Sarah Regina Scotta
Published: May 2022

Entrevista
O CAMPO INTERDISCIPLINAR ENTRE AS ÁREAS DE EDUCAÇÃO E COMUNICAÇÃO: O POTENCIAL DO RÁDIO NO ÂMBITO EDUCACIONAL
Authors: Crepaldi André
Published: May 2022

O presente artigo tem por objetivo descrever a contribuição e uso do rádio como meio de produção de conteúdo educativo por alunos no programa JC Papo Reto, veiculado aos sábados no período matutino, pela emissora comunitária Norte FM, de Cascavel-PR. Nos últimos anos observou-se um aumento de estudos e práticas a partir do uso de tecnologias de informação e comunicação – TIC em sala de aula, pela identificação, por parte do professor, sobre as potencialidades que podem oferecer. Para tanto, o rádio tem sido com frequência apropriado como ferramenta de estímulo ao conhecimento, uma vez que pode potencializar o ensino e aprendizagem. A pesquisa é um estudo de caso com levantamento bibliográfico e entrevista semiestruturada, realizada entre os dias 09 de dezembro de 2019 a 06 de janeiro de 2020. O estudo demonstrou que o programa JC Papo Reto tem sido um espaço democrático na mídia, contemplando a produção e estímulo ao conhecimento, trabalho coletivo, construção de projetos, pensamento crítico, desenvolvimento da escrita e expressão. Além disso, destaca-se a construção da autonomia e formação de comunicadores comunitários.
SABERES DO RITUAL DA MOÇA NA CONSTRUÇÃO DO SUJEITO TEMBÉ, NO TERRITÓRIO DO GUAMÁ
Authors: Furtado Mairon De Sousa , Pilletti Edileuza Amoras
Published: May 2022

O ritual de passagem, enquanto movimento milenar da cultura indígena, é compreendido como campo privilegiado de construção, circulação e apropriação de saberes que se fazem presentes nos processos de organização, preparação e desenvolvimento do Ritual. Com isso, o objetivo da pesquisa é compreender o saber-fazer Ritual de Passagem da Menina Moça na construção do sujeito Tembé do Alto Rio Guamá, Nordeste paraense. O estudo ocorreu na aldeia Sede, da Terra Indígena do Alto Rio Guamá, Nordeste paraense, onde foi utilizado observação participante, entrevista semi-estruturada, conversas informais e caderno de campo na coleta de dados vinculado aos saberes-fazeres da festa da menina moça Tembé, com abordagem qualitativa e análise de conteúdo. As observações permitiram perceber um complexo de saberes-fazeres que perpassam pela prática ritual, se fazendo presente uma diversidade de elementos do território, fato que nos mostra a relevância da biodiversidade para a realização e perpetuação do Ritual, onde não é possível pensar o ritual da moça desvinculado do espaço vivido, o qual é determinante para a construção do ser e da cultura Tembé. Portanto, a cerimônia Tembé se mostrou um rico espaço de múltiplos aprendizados, a emersão e apropriação de saberes-fazeres no contexto da organização, no caçar, na extração vegetal, no fazer adornos, na pintura, no preparo dos alimentos, no cantar, no dançar, enfim, os quais contribuíram para a construção dos sujeitos e fortalecimento da cultura Tembé.
Spring cardiology round-up
Authors: Greener Mark
Published: May 2022

Mark Greener looks at the latest research into cardiovascular conditions
Transforming respiratory care – innovation or necessity?
Authors: Loveridge Christine
Published: May 2022

Christine Loveridge explains how respiratory care can be improved in the wake of the COVID pandemic
Development of a low-cost iot platform for data collection
Authors: Silva Daniela Andreska da , Mariano Arthur Breno Rocha , Sousa Alan Bernard Oliveira de
Published: May 2022

Precision agriculture in the Internet of Things (IoT) integrates different technologies able to raise crop productivity, optimize resource efficiency, and accelerate decision making. However, the adoption of this technology is usually costly, affecting the acquisition by the farmers. Thus, the objective of this work was to develop and evaluate low-cost hardware to obtain data in a hydroponic system via IoT. The experiment was conducted at the Pici Campus of the Federal University of Ceará and split into three distinct stages. Firstly, the DS18B20 temperature sensors were calibrated in water, using the KR380 infrared thermometer as a comparison method. For the second step, when the hydroponic system was installed, the water temperature was monitored in the channel and not in the solution reservoir. In this same phase, the quality of data sending and receiving was investigated. In the third step, the sensory data were analyzed with those obtained by the local Meteorological Station. The calibration results revealed that the DS18B20 sensor has reasonable accuracy and excellent agreement and reliability between data. As for receiving and storing, only 6% of the total data was lost.
A sociologist in the field of social work: Pierre Bourdieu’s theory and its relevance for social work practice
Authors: Wolniak Michal , Houston Stan
Published: May 2022

The literature considering Bourdieu’s social theory and its relevance for social work is multifaceted and growing. An evaluation of this body of work is now pressing. This critical literature review explores 34 published works on this subject. Six themes emerged from a thematic analysis of the corpus: (1) the intersection between class and poverty; (2) power and symbolic domination; (3) neoliberalism and the state; (4) reflexivity; (5) relations between social workers and other professionals; and (6) the critique of Bourdieu’s thinking and its relevance for social work. The findings show that Bourdieu’s social theory can augment critical and radical social work, especially when the concepts of habitus, capital, field and reflexivity are embraced. Significantly, though, it was discovered that the ‘symbolic’ part of Bourdieu’s theory had been incompletely covered and required much more attention, as it is integral to the understanding of oppression in society.
Predicting the dynamical behaviors for chaotic semiconductor lasers by reservoir computing
Authors: Li Xiao-Zhou , Sheng Bin , Zhang Man
Published: May 2022

We demonstrate the successful prediction of the continuous intensity time series and reproduction of the underlying dynamical behaviors for a chaotic semiconductor laser by reservoir computing. The laser subject to continuous-wave optical injection is considered using the rate-equation model. A reservoir network is constructed and trained using over 2 × 104 data points sampled every 1.19 ps from the simulated chaotic intensity time series. Upon careful optimization of the reservoir parameters, the future evolution of the continuous intensity time series can be accurately predicted for a time duration of longer than 0.6 ns, which is six times the reciprocal of the relaxation resonance frequency of the laser. Moreover, we demonstrate for the first time, to the best of our knowledge, that the predicted intensity time series allows for accurate reproduction of the chaotic dynamical behaviors, including the microwave power spectrum, probability density function, and the chaotic attractor. In general, the demonstrated approach offers a relatively high flexibility in the choice of reservoir parameters according to the simulation results, and it provides new insights into the learning and prediction of semiconductor laser dynamics based on measured intensity time series.
Distributed fiber optic sensing with enhanced sensitivity based on microwave-photonic Vernier effect
Authors: Zhu Chen , Roman Muhammad , Zhuang Yiyang , Huang Jie
Published: May 2022

The Vernier effect has been widely used in the field of measurement and instrumentation for sensitivity enhancement. Single-point optical fiber sensors based on the Vernier effect have been extensively reported in recent years. In this Letter, for the first time, a distributed optical fiber sensor based on microwave photonics with improved sensitivity enabled by the Vernier effect is demonstrated. Distributed sensing is realized by interrogating a Fabry–Perot interferometer (FPI) array formed by cascaded reflectors along an optical fiber using an optical carrier-based microwave interferometry (OCMI) system. A reference FPI is also included in the system. The interferogram of each of the sensing FPIs can be unambiguously reconstructed and superimposed with the reconstructed interferogram of the reference FPI to generate the Vernier effect. By tracking the spectral shift of the envelope signals in the superimposed spectra, the measurement sensitivities of the sensing FPIs can be significantly improved. A simple direct modulation-based OCMI system is used in the proof-of-concept demonstration, showing sensitivity-enhanced distributed sensing capability. Moreover, the sensitivity amplification factor can be adjusted by varying the optical length difference of the sensing and reference FPIs, similar to that of Vernier effect-based single-point optical fiber sensors.
Triangular gold nanoplates integrated microgel-based sensor for urinary tract infection and glucosuria detection
Authors: Chowdhury Eshanee , Zubair Ahmed
Published: May 2022

A glucose-responsive photonic crystal integrated optical sensor that can detect glucosuria and urinary tract infection was designed by comprehensive numerical analysis. We showed a comparative study of nanoparticle shapes and materials and discussed the performance parameters of the sensor, such as the signal-to-noise ratio, the sensitivity, and the detection limit for various pH levels. Normally distributed nanoparticles were embedded within a functionalized microgel matrix in this proposed structure, and the theoretical study was conducted using the finite element method. Gold was selected as a photonic crystal material due to its nontoxicity and better sensing performance, and triangular-shaped nanoplates were chosen due to their better surface plasmon resonance performance. The sensor showed improved sensitivity of <85.65 nm/mM for pH 7.4, and <110.60 nm/mM for pH 8.0. It depicted a lower detection limit of >0.34 mM for pH 7.4 and >0.30 mM for pH 8.0 than those of previously reported glucose sensor studies. Moreover, the proposed glucose sensor exhibited a practicable signal-to-noise ratio and sensor resolution range. This label-free sensor manifested additional features such as reusability of the sensor, high sensing reversibility, and being readily usable at point-of-care medical facilities.
Improving access to care and community health in Haiti with optimized community health worker placement
Authors: Champagne Clara , Rajkumar Andrew Sunil , Auxila Paul , Perrone Giulia , Plötz Marvin , Young Alyssa , Bazaz Jazayeri Samuel , Napier Harriet G. , Le Menach Arnaud , Battle Katherine , Amratia Punam , Cameron Ewan , Alfred Jean-Patrick , Deslouches Yves-Gaston , Pothin Emilie
Published: May 2022

The national deployment of polyvalent community health workers (CHWs) is a constitutive part of the strategy initiated by the Ministry of Health to accelerate efforts towards universal health coverage in Haiti. Its implementation requires the planning of future recruitment and deployment activities for which mathematical modelling tools can provide useful support by exploring optimised placement scenarios based on access to care and population distribution. We combined existing gridded estimates of population and travel times with optimisation methods to derive theoretical CHW geographical placement scenarios including constraints on walking time and the number of people served per CHW. Four national-scale scenarios that align with total numbers of existing CHWs and that ensure that the walking time for each CHW does not exceed a predefined threshold are compared. The first scenario accounts for population distribution in rural and urban areas only, while the other three also incorporate in different ways the proximity of existing health centres. Comparing these scenarios to the current distribution, insufficient number of CHWs is systematically identified in several departments and gaps in access to health care are identified within all departments. These results highlight current suboptimal distribution of CHWs and emphasize the need to consider an optimal (re-)allocation.
A day in the life: Using contextual interviews to understand the health of home-based Mapuche weavers
Authors: Gracia Gabriela , Guzman Alison , Forst Linda
Published: May 2022

The craft sector employs 305 million people worldwide, primarily women, rural and home-based workers. Home-based weavers, an understudied workforce, are subject to a range of hazards and adverse health effects related to their weaving work and domestic responsibilities (e.g., housework, farm work, childcare, eldercare). The Mapuche represent Chile’s largest Indigenous group with about 20 percent residing in the Araucanía region, where agriculture and tourism, including craftwork, are important sources of income. Using a purposive sampling approach, we conducted Spanish-language contextual interviews (N = 10) with Mapuche weavers across four communities, allowing us to observe participants in their home settings, watching them weave and discussing tasks, decision-making, and behaviors during the work process. Participants ranged in age from 29–55 years. A combination of semi-structured, audio-recorded interviews, videos, photographs and written observations yielded a time-wheel of a typical day for each weaver; the types of weaving and non-weaving work (including hours per day); workspace visuals; self-reported health problems, causes and treatments; exposure hazards; and potential ergonomic interventions. In addition to weaving, housework (n = 10), farm work (n = 7), wool production (n = 7), natural and chemical dyeing (n = 7) and child-rearing (n = 4) were identified as work activities. The most commonly cited weaving-related health problems were eyestrain (n = 7) and pain in the back (n = 6), shoulder (n = 5), arm (n = 4), hand (n = 4), neck (n = 3), wrist (n = 3) and fingers (n = 3). When asked to identify potential improvements to their weaving workspace, participants identified the need to having a dedicated workspace for weaving (n = 7), improving their existing workspace with better seating (n = 4), lighting (n = 3), insulation (n = 2) and increasing the size of their workspace (n = 2). This methodology, blending traditional occupational health tools with qualitative methods, was instrumental in understanding the range of hazards associated with home-based work and identifying potential ergonomic interventions for this global workforce.