bluuebunny/crossref_metadata_2025 huggingface dataset:
Semen quality among men attending urology services in the Dschang Health District, west Cameroon: A retrospective study on 379 cases
Authors: Césaire Momo Tetsatsi Aimé , Alumeti Munyali Désiré , Romeo Bonsou Fozin Georges , Ngadjui Esther , Wankeu-Nya Modeste , Watcho Pierre
Published: March 2020

Background: Infertility is a common condition affecting at least 15% of couples worldwide, and male factors are involved in about half of this prevalence rate. In Cameroon, about 20%-40% of couples are the victims. However, the sperm characteristics of infertile men are yet to be described in the health districts in Cameroon for better management of male infertility.
Objective: The present study was designed to assess the sperm profile and related sociodemographic factors of men attending the urology services at the Dschang Health District. Materials and Methods: It consisted of a 10 yr retrospective study carried out in the Dschang Health District. The results of patients’ semen analysis (SA) were computed using Epi Info software and expressed as qualitative and quantitative spermogram state as described by the clinician and sociodemographic features of those patients.
Results: Out of the 379 patients studied, 83.91% had abnormal spermogram. Patients older than 50 yr were the most affected when grouped into age categories. With regard to patient’s profession, 52.51% had specified their profession and from that group, although farmers (9.31%) represented the lowest size category, they were the most affected with 94.74% having abnormal spermogram.
Conclusion: This study indicates that the sperm damage is the major cause of male infertility in the Dschang Health District. It also shows that farmers are the most affected category and it could be linked to the long-term exposure to pesticides. These results call for the assessment of the reproductive toxicity of locally used pesticides.
Key words: Sperm damage, Male infertility, Semen analysis, Dschang Health District.
Increased rate of elective cesarean delivery following assisted reproductive technology: A letter to the editor
Authors: Ranjbar Fahimeh , Gharacheh Maryam
Published: March 2020

This is a Letter to Editor and does not have an abstract.
The effect of vitamin D status on ovarian reserve markers in infertile women: A prospective cross-sectional study
Authors: Alavi Nazanin , Ebrahimi Mahbod , Akbari-Asbagh Firoozeh
Published: March 2020

Background: Vitamin D deficiency and infertility are two important health problems in Iran. Some studies suggest that vitamin D may influence Anti-Müllerian hormone (AMH) and antral follicle count (AFC) as an ovarian reserve.
Objective: The present study aimed to investigate the impact of vitamin D on AMH serum concentrations/AFC.
Materials and Methods: three hundred and five infertile women referred to the IVF Unit of Yas hospital, between July and December 2017, were enrolled in this cross-sectional study. The demographic characteristics of the participants, as well as the serum levels of vitamin D, AMH, and ultrasonic examination of AFC were recorded.
Results: Finally, 287 infertile women were included in the analysis with a mean age of 29.95 ± 4.73 yr (18-45 yr) and a mean Body mass indexof 25.11 ± 4.41 kg/m2. The median AMH and vitamin D levels were 3.20 and 22.82 ng/ml, respectively. Considering the cut-off level of 20 ng/ml, 58.7% were vitamin D deficient. Regression analysis showed no association between AMH and vitamin D levels (p = 0.161), even after adjusting for baseline variables (p = 0.182). A total of 120 patients had an AFC < 6 and 164 ≥ 6, which was not statistically different between the groups with normal level or deficient vitamin D (p = 0.133).
Conclusion: The present cross-sectional study showed no significant association between serum levels of vitamin D and AMH or AFC in infertile women, even after adjusting for baseline variables.
Key words: Anti-Müllerian hormone, Infertility, Vitamin D deficiency, Ovarian follicle.
Corrigendum to “Interstitial ectopic pregnancy diagnosis by three-dimensional ultrasound and its laparoscopic management: A case report” [Int J Reprod BioMed 2019; 17: 945-950]
Authors: Ahmadi Firoozeh , Pahlavan Fattaneh , Ramezanali Fariba , Akhbari Farnaz
Published: March 2020

The publisher has been informed of an error that occurred on page 945 in which the Institute name must be changed to Royan instead of Rayan. On behalf of the author, the publisher wishes to apologize for this error. The online version of the article has been updated on 29 February 2020.
29-kDa: A Potential Candidate for Anti-Tick Vaccine Antigen Source as Immunogenic and Stage Reactive Targeting Hard-Bodied Hyalomma Ticks Ixodidae
Authors: Kamran Kashif , Villagra Cristian A , Iqbal Asim , Kakar Asmatullah , Schapheer Constaza , Taj Muhammad Kamran , Ali Abid , Siddiqui Saima
Published: March 2020

The objective of present study is to develop a vaccine against Hyalomma hard-bodied tick and to analyze relevant experimental data on immunized indigenous horse breed Morna. Montanide (ISA-50) adjuvant-based vaccine induced significantly (pandlt;0.02) higher antibody titre through intradermal route with 99.98% vaccine efficacy. Humoral response was determined though indirect ELISA; where peak level of serum antibody was recorded after six weeks interval of post-immunization. Most of hematology and biochemical parameters remained consistent to normal reference values. Our report also indicates a significant percentage decline in the numbers of engorged ticks, eggs mass, eggs number and increased tick rejection. The animal travel history can promote tick burden and is a potential risk factor. Based on biological and hematological parameters, it is possible to conclude that 29-kDa antigen can be used as an effective antigen vaccine candidate to control tick infestation detected through humoral response.
Potential Effect of β-casomorphin-7 on Lymphocyte and TLR\NF-κB Signaling Pathway in Intestinal Mucosa of Aged Mice
Authors: Yin Hong , Su Xiaqing , Liu Jijie , Li Lihua , Li Lihua , Tian Ying , Peng Jing
Published: March 2020

The effect of â-Casomorphin-7 on intestinal mucosal immunity was investigated in aged mice. Mice were treated without or with different doses of â-Casomorphin-7 for 30 days. All mice were sacrificed and intestinal mucosa samples collection at the end of the experiment. Histopathological studies showed the tissue protective role of â-Casomorphin-7 in aged mice. The number of duodenal and jejunal epithelial lymphocytes decreased significantly Pandlt;0.05 The doses of duodenal and jejunal epithelial lymphocytes in mice were significantly Pandlt;0.05 increased in each dose group. The relative expression of TLR4,TRAF6 and NF-êB in the intestinal mucosa of the elderly model group was lower than that of the young control group. The low and middle dose groups significantly Pandlt;0.05 up-regulated the relative expression of TLR4, TRAF6 and NF-êB.The results suggest that â-Casomorphin-7 can improved intestinal mucosal immune decline likely through balancing TLR4\NF-êB signaling pathway.
Pathological Conditions Associated with Physaloptera Stomach Worm Infestation in Bengal Monitor Lizard Varanus bengalensis
Authors: Manjunatha V , Rout M , Muniyellappa H K , Roopa S , Shivashankar B P , Byregowda S M
Published: March 2020

The present study reports pathological conditions associated with Physaloptera sp. stomach worm infestation in Bengal monitor lizard (Varanus bengalensis). Four adult Bengal monitor lizards were rescued from the poachers and kept at Wild Animal Rescue and Rehabilitation Centre, Bannerghatta Biological Park, Bengaluru. Faecal samples from all were collected and examined. Physaloptera sp. ova were found in all faecal samples examined by sedimentation technique. One Bengal monitor lizard died during the period and systematically examined at necropsy for gross pathological lesions. Adult Physaloptera sp. nematodes were found to be firmly attached to the gastric mucosa causing erosive inflammatory foci. Histopathological examination of stomach revealed the presence of many immature and mature worms encapsulated within fibrous connective tissue. The intestinal villi were stunted and many cross sections of the worms could be demonstrated in the lumen. The worms also migrated to liver parenchyma and got encapsulated with fibrous connective tissue with infiltration of eosinophils in the sinusoids and the vascular tissue spaces. This seems to be the first report of Physaloptera sp. nematodiasis in Bengal monitor lizard kept under captivity for a period of 1.5 months.
Influence of Lactation Order and Lactation Stage on Physico-Chemical Properties of Pantja Goat Milk
Authors: Chauhan Surya Pratap Singh , Kumar Sanjay , Singh D V , Sharma R K , Palod Jyoti , Prabhakaran P
Published: March 2020

Goat is a versatile animal having short generation interval with lower investment cost and higher prolificacy. The present study was carried out at Goat farm, LPM, GBPUAT, Pantnagar. During the entire study the fresh milk samples of Pantja goats were taken according to lactation order and stage viz., 1st (Upto 30 days), 2nd (31 to 60 days) and 3rd (above 61 days) stage of lactation were analyzed for physico-chemical properties. The values of milk composition were significantly affected by lactation order and stage of lactation and their interaction. The color of Pantja goat milk was perfectly white in all the lactation order and lactation stages. The specific gravity and boiling point of milk increased significantly from 1st to 3rd lactation order and with advancement of lactation stage. The milk composition; fat, protein, total solids, solids not fat, total ash and chemical properties viz.titratable acidity of milk was increased significantly in advanced lactation order and stage of lactation except, pH, water and carbohydrate which showed a declining trend
Influence of Customized Supplement on Voluntary Feed Intake and Nutrient Metabolism in Crossbred Calves
Authors: Chaudhary Sandeep K , Dutta Narayan , Jadhav S E , Pattanaik A K
Published: March 2020

The present study was carried out to ascertain the effect of dietary inclusion of a customised supplement to farmers’ based diet on voluntary feed intake and nutrient metabolism in crossbred calves. In order to carry out the experiment, fifteen crossbred calves (18 months old; 166.53±4.93 kg mean BW) were randomly allocated to 3 groups (5 calves in each group) as CON, Treat and SBR, in a CRD for 30 days. The calves in CON (control) group were fed on cereal straw based diet with concentrate mixture as per the farmers’ practices, whereas, the calves in Treat were fed according to CON with additional customized supplement @ 0.25% of BW. The calves in SBR group were fed standard diet as per Kearl (1982). The intake (gd-1) of DM and OM was significantly Pandlt;0.01 higher in SBR than Treat and CON groups, while DM and OM intake as % of BW in Treat group has an intermediate position between SBR and CON groups. The concentrate intake (gd-1) was significantly Pandlt;0.001 higher in SBR followed by Treat and CON group, respectively. However, intake of wheat straw and green maize was found to be identical Pandlt;0.05 among all the groups. The digestibility coefficient of DM, OM, CP, NDF and ADF was significantly Pandlt;0.05)higher in Treat and SBR groups than CON. The N-retention as per cent of intake and absorbed-N was significantly Pandlt;0.001 higher in Treat and SBR groups than CON. The Ca and P retention gd-1 was significantly Pandlt;0.001 higher in SBR group followed by Treat and CON groups. The intake gd-1 and density % of DCP and TDN were significantly Pandlt;0.001 higher in SBR group followed by Treat and CON groups. Thus, it can be concluded that supplementation of the customised supplement (@ 0.25% of BW) to CON diet significantly improved the voluntary feed intake and nutrient metabolism in crossbred calves.
CLINICAL AND EPIDEMIOLOGICAL FEATURES OF INFECTIONS ECOLOGICALLY RELATED TO TICKS IN THE CHELYABINSK REGION
Authors: Konkova-Reidman Alena Borisovna , Barsukova D. N. , Bondarenko E. I. , Shvalov A. N. , Lucinina S. V.
Published: March 2020

An analysis of the incidence in the dynamics of years (1998-2018) showed that the leading place among infections transmitted by ixodid ticks in the Chelyabinsk region is occupied by tick-borne tick-borne borreliosis (IKB), tick-borne encephalitis (TBE) is less common. Long-term monitoring of the natural foci of TBE and IKB showed their high epizootological potential. In 2018, febrile forms prevailed in the structure of clinical forms of TBE - 61.9%, meningeal and focal forms were found in 28.5% and 9.4%, respectively. Focal forms were represented by meningoencephalitic and polioencephalomyelitis forms with the same frequency of 4.7%. In the structure of the nosological diagnosis of ICD in the South Urals, erythema forms of the disease prevail (69.5%). The detection frequency of Borrelia DNA of the pathogenic complex B.burgdorferi s.l. in the blood serum and leukocyte fraction of patients was 13%. In 4 patients, for the first time in the Chelyabinsk region, DNA of a new Borrelia miyamotoi Borrelia genotype was detected in whole blood samples and in the samples of the leukocyte fraction using PCR-RV. Phylogenetic analysis of B. miyamotoi was carried out on all sequences of glpQ and 23SrRNA gene fragments, deposited at NCBI and homologous sequences of Chelyabinsk-2018 isolates. The disease proceeded in non-erythema form, intoxication syndrome, myalgia, chills were observed in the clinical picture.
DRUGS CONTAINING GLYCYRRHIZIC ACID IN COMPLEX THERAPY FOR PULMONARY TUBERCULOSIS
Authors: Riasenskii Dmitrii Sergeevich , Grishkina N. A , Aseev A. V
Published: March 2020

The effectiveness of etiotropic chemotherapy is largely determined by the tolerability o the TB drugs (TBD) and the severity of unwanted side effects. It is known about the immunopathological effect of TBD, which can also be attributed to the undesirable effects of anti-tuberculosis chemotherapy. Changes in the structure and composition of mononuclear membranes reflect their functional activity. Secondary disorganization of the lipid bilayer due to the action of TBD is an important element in the development of immunosuppressive conditions in pulmonary tuberculosis and requires specific correction. The paper has the results of a survey of 308 patients with tuberculosis included. The comparison group consisted of 36 healthy volunteers. The membrane destruction coefficient and cholesterol-phospholipid ratio were used in order to assess the state of peripheral blood mononuclear cells and the degree of structural disorganization of their membranes. The prescription of preparations containing glycyrrhizic acid is pathogenetically substantiated and allows improving the state of the membranes of mononuclear cells, thereby reducing the undesirable membrane-toxic effect of first-line anti-tuberculosis drugs, There was an increase in etiotropic therapy intensity on the basis of abacilation at the end of the intensive phase of the main course of chemotherapy from 61% to 72.4% when using Licorice Root, and to 81.3% when using Fosfogliv® in patients with focal and infiltrative pulmonary tuberculosis.
ETIOLOGY OF SKIN LEISHMANIOSIS IN OF ENDEMIC REGIONS OF UZBEKISTAN ON THE EXAMPLE OF DZHIZAK REGION
Authors: Suvonkulov U. T , Achilova Olesya Djurabaevna , Muratov T. I , Tai Soon Yong , Myunhee Yi , Ju Yeong Kim , Turicin V. S
Published: March 2020

Taking into account the high prevalence of cutaneous leishmaniasis in Uzbekistan, as well as the tendency of increase in the incidence of this disease over the past 5 years, important and necessary is to determine the species composition of leishmania, as well as their vectors and natural reservoirs. According to the results of molecular-biological diagnostics, carried out in present study, in samples taken from ulcers of patients from Jizzakh region, which previously considered endemic for anthraponotic cutaneous leishmaniasis, was detected L.mayor, the causative agent of zoonotic cutaneous leishmaniasis.
Jigsaw learning versus traditional lectures: Impact on student grades and learning experience
Authors: Costouros Teresa
Published: March 2020

Despite significant research supporting active learning, many professors continue to use traditional lectures as their primary teaching method, particularly in introductory level courses. This article explores whether jigsaw cooperative learning had a positive impact on student grades and enhanced their learning experience, as compared to the traditional lecture method. The question was answered by collecting data from an insurance and risk management introductory course in the business school. To answer the question on learning experience, students completed a validated survey on each pedagogy, consisting of 15 statements that they rated on a Likert scale of 1 to 5, strongly disagreeing or agreeing with the statements. The course content was taught using lectures for four learning modules and the jigsaw learning method for four learning modules. After each module, a quiz was written by each student, and these grades were compared to establish the impact of each teaching method on student grades. Data was analyzed using descriptive statistics and two-way ANOVA testing to determine significant differences. Data was collected from two student groups. One group was a traditional university group of diverse students and the other group consisted of international students from India. I compared the results of the two student groups to identify any differences. This research adds to the studies on active learning in insurance education, specifically jigsaw cooperative learning. It also contributes to literature on effective teaching strategies for international student groups.
Do we know what they are thinking? Theory of Mind and affect in the classroom
Authors: Knupsky Aimee , Caballero M. Soledad
Published: March 2020

Research on Theory of Mind explores how we develop the capacity to understand that others have thoughts and feelings that differ from our own and how we are compelled to “read” them. However, a preponderance of evidence from the cognitive humanities and cognitive neurosciences tells us that our readings are often misguided or just plain wrong. None of this work has considered how teachers and learners might engage in open conversations about theory to mind to identify misperceptions and enhance their understanding of one another’s thoughts and reactions in the classroom. In this essay, we explore how using what we call “Theory of Minding” as a rhetorical device may invite moments of vulnerability and of clarification when we engage in learning with our students, thus enhancing classroom dynamics. We describe how the idea of Theory of Minding developed, present an initial evaluation of it by students, and situate this technique in the rich literature about affect and pedagogy. We propose that using Theory of Minding in the classroom can be used to encourage more authentic and interactive engagement.
The Teaching–Learning of Caring Nursing Using a Hands, Head, Heart Debriefing Tool Following High-Fidelity Simulation
Authors: Onley Michelle , Zavertnik Jean Ellen
Published: March 2020

High-fidelity simulation presents challenges when attempting to incorporate caring and other components of the affective learning domain. A quasi-experimental research study was conducted to determine if the use of a “Hands, Head, Heart” debriefing structure would increase students' understanding of caring behaviors and their importance following a high-fidelity simulation experience. Although there was no statistical difference between groups, the intervention group reported feeling better equipped to recognize caring behaviors when the Hands, Head, Heart debriefing structure was utilized. Almost all students found debriefing to be a valuable part of the simulation experience.
Health Concerns of Perimenopausal Women
Authors: Hou Pen-Hsin , Tsao Lee-Ing
Published: March 2020

BackgroundPracticing perimenopausal health promotion is an important key stage for the healthy life of the coming elderly. However, there are few studies conducted on these women's subjective health concerns. Getting insight into their health concerns can help women implement their own health promotion lives.AimsThe goal is to generate data from the in-depth interview for perimenopausal women based on their perceptions, beliefs, values, and feelings regarding perimenopausal women’s subjective health concerns.Methods:The qualitative research by using content analysis was applied. In-depth interviews were conducted with 19 perimenopausal women with a mean age of 51.31 years. The constant comparative method was used to analyze the interview data.ResultsTwo themes and their subthemes were identified: (a) “Evaluating Health” - “Suspecting a menopausal disease or illness”, “Easily feel tired, lack energy, and feel not as strong as before”, “Worried about my abnormal physiological data” and (b) “Remaining Young” – “Worried that I lost my female characteristics and reproductive function”, “Weight loss is the focus of life, but it is not easy to achieve.”Conclusion“Evaluating Health” and “Remaining Young” are two health concerns for perimenopausal women. It is crucial for health providers to advocate these two concerns as slogans for perimenopausal health promotion women.
Relativistic Effects Appearing at Non-Relativistic Speeds
Authors: Kawashima Kenji
Published: March 2020

We study the center of energy (CE) before and after the separation of superposed wave from a moving medium (MM). It is assumed that two out-of-phase mechanical transverse waves propagating from the opposite directions on a medium moving at non-relativistic speeds are superposed and the superposed portion (SP) is separated from the MM at that moment. We consider the CE of the SP before and after the separation from the MM. The location of CE (LCE) of the SP seems to be at the center of it at the moment of superposition. The SP rotates due to the separation from the MM since the velocity of each portion symmetric with respect to the center of the SP is equal in magnitude and opposite in direction. The magnitudes of velocities of the symmetric portions become different as soon as the SP begins to rotate with the separation from the MM. Then the energies of their symmetric portions are not the same, so the LCE of the SP is not at the center of it. As a result, the LCE of it looks different before and after the separation from the MM. We must find a solution to keep the LCE of the SP constant. We propose that two out-of-phase mechanical transverse waves (MTWs) propagating from the opposite directions on a MM originally have hidden difference in relativistic energy and it suddenly appears within the range observable in Newtonian mechanics when the SP starts rotating. This means that the point of view of hidden difference in relativistic energy is necessary to keep the LCE constant.
Role of Bio-Fertilizers in Sustainable Agriculture
Authors: Akram Muhammad Salman , Cheema Muhammad Abubakar , Waqas Muhammad , Bilal Muhammad , Saeed Muhammad
Published: March 2020

For years chemical fertilizers are used to fulfill the soil requirement of nutrients and yield, but large amount of these chemical fertilizers are dangerous for environment, beneficial microbes, animals, and humans as well. Therefore, environmental friendly and cost effective biofertilizers are used. Biofertilizer are the substances which contain microorganisms those microorganisms may be fungi, bacteria, and protozoa which have ability to increase fertility of soil by Nitrogen fixation, Phosphorous solubilization, and Iron sequestration. These processes convert insoluble form of nutrients into soluble form and make it available to the roots of plant which easily take them up and utilize them. There are variety of the crops whose productivity can be increased by applying biofertilizer such as rice, oat, and other grain crops. In this review we go through the way of application of biofertilizers, and how the help the plants and in which they help.
PERCEPATAN JURNAL KEWIRAUSAHAAN DAN BISNIS MENUJU AKREDITASI NASIONAL
Authors: Susantiningrum Susantiningrum , Triharyanto Eddy , Yudhistira Bara , Hantari Dimar
Published: March 2020

Jurnal Kewirausahaan dan Bisnis (JKB) has p-ISSN and e-ISSN. In 2017 JKB socialization activities were carried out to publish the journal to all regions in Indonesia and to attract more varied writers, especially those from outside Universitas Sebelas Maret (UNS). Furthermore, JKB development activities are needed towards reputable journals by adopting the Direktorat Jenderal Pendidikan Tinggi Regulation No. 1 of 2014 concerning Accreditation Guidelines for Scientific Issues. This study aims to improve the quality and capacity of management study centers, especially in managing Jurnal Kewirausahaan dan Bisnis towards reputable journals, such as by preparing national journal accreditation requirements. Activities that have been carried out included: initial coordination of activities, submitting to the national index institute, workshop on simulation of journal appraisal towards national accreditation, and workshop on the national accreditation program for JKB.
Keywords: journal, institution, entrepreneurship, accreditation
 

 
Application of Mesh Adaptive Derivative-Free Optimization Technique for Gas-Lift Optimization in an Integrated Reservoirs, Wells, and Facilities Modeling Environment
Authors: Khoshkbarchi Mohammad , Rahmanian Mohammad , Cordazzo Jonas , Nghiem Long
Published: March 2020

Gas-lift is an important artificial lift strategy for increasing the production of hydrocarbons from heavy oil and offshore reservoirs with declining pressure. The optimum design and operation of gas-lift has a considerable impact on the optimum production and economics of the entire field and can only be achieved by considering all related variables in connected reservoirs, gas-lifted wells and facilities. Therefore, it is essential to formulate the gas-lift model as an optimization problem within an integrated modeling environment, where all the time dependent physical and operational constraints of reservoirs, wells and facilities can be collectively taken into account during the time evolutionary modeling of the asset. However, this could pose a computationally challenging problem for most derivative based optimizers, as some of the governing equations and models representing the gas-lifted asset could be very nonlinear, physically or mathematically discontinuo us, and the system may not have a solution under some of the conditions proposed by the optimizer due to physical operational restrictions or infeasibility. To overcome these problems we applied a mesh adaptive direct search (MADS) derivative free optimization technique to optimize the gas-lift problems in an integrated reservoir, wells and production facilities environment. The results proved the suitability of the MADS strategy for optimizing these systems particularly for systems with narrow or discontinuous boundaries of physical operation.
Efficient Coupled Multiphase-Flow and Geomechanics Modeling of Well Performance and Stress Evolution in Shale-Gas Reservoirs Considering Dynamic Fracture Properties
Authors: Liu Lijun , Liu Yongzan , Yao Jun , Huang Zhaoqin
Published: March 2020

Significant conductivity losses of both propped hydraulic fractures and unpropped natural fractures are widely observed by laboratory experiments and field studies in shale-gas reservoirs. Previous studies have not well-considered the effects of dynamic fracture properties, which limit the accurate prediction of well performance and stress evolution. In this study, an efficient coupled flow and geomechanics model is proposed to characterize the dynamic fracture properties and examine their effects on well performance and stress evolution in complex fractured shale-gas reservoirs. In our proposed model, a unified compositional model with nonlinear transport mechanisms is used to accurately describe multiphase flow in shale formations. The embedded discrete fracture model (EDFM) is used to explicitly model the complex fracture networks. Different fracture constitutive models are implemented to describe the dynamic properties of hydraulic fractures and natural fractures, respectively. The finite-volume method (FVM) and finite-element method (FEM) are used for the space discretization of flow and geomechanics equations, respectively, and the coupled problem is solved by the fixed-stress split iterative method. The coupled model is validated against classical analytical solutions. After that, the proposed model is used to investigate the effects of hydraulic-fracture and natural-fracture properties on production behavior as well as pressure and stress evolution of shale-gas reservoirs. With the dynamic fracture properties incorporated, our model can predict the well production more accurately, and provide more realistic stress evolution that is essential for the design and optimization of refracturing and infill-well drilling.
Functional Outcomes and Complications of Intramedullary Fixation Devices for Midshaft Clavicle Fractures: A Systematic Review and Meta-Analysis.
Authors: Hoogervorst Paul , Dam Tess van , Verdonschot Nico , Hannink Gerjon
Published: March 2020

Background An alternative to the current gold standard in operative treatment of displaced midshaft clavicle fractures (DMCF) using plate osteosynthesis, is internal fixation by means of intramedullary fixation devices. These devices differ considerably in their specifications and characteristics. The aim of this systematic review is to generate an overview of functional outcomes and complications in the management of DMCF per available intramedullary device.Methods A systematic review was conducted to identify all papers reporting functional outcomes, union rates and/or complications using an intramedullary fixation device for the management of midshaft clavicle fractures. Multiple databases and trial registries were searched from inception until February 2020. Meta-analysis was conducted based on functional outcomes and type of complication per type of intramedullary fixation device. Pooled estimates of functional outcomes scores and incidence of complications were calculated using a random effects model. Risk of bias and quality was assessed using the Cochrane risk of bias and ROBINS-I tools. The confidence in estimates were rated and described according to the recommendations of the GRADE working group.Results Sixty-seven studies were included in this systematic review. The majority of studies report on the use of Titanium Elastic Nails (TEN). At 12 months follow up the Titanium Elastic Nail and Sonoma CRx report an average Constant-Murley score of 94.4 (95%CI 93-95) and 94.0 (95%CI 92-95) respectively (GRADE High). The most common reported complications after intramedullary fixation are implant-related and implant-specific. For the TEN, hardware irritation and protrusion, telescoping or migration, with a reported pooled incidence 20% (95%CI 14-26) and 12% (95%CI 8-18), are most common (GRADE Moderate). For the Rockwood/Hagie Pin, hardware irritation is identified as the most common complication with 22% (95%CI 13-35) (GRADE Low). The most common complication for the Sonoma CRx was cosmetic dissatisfaction in 6% (95%CI 2-17) of cases (GRADE Very low). Conclusion Although most studies were of low quality, good functional results and union rates irrespective of the type of device are found. However, there are clear device-related and device-specific complications for each. The results of this systematic review and meta-analysis can help guide surgeons in choosing the appropriate operative strategy, implant and informing their patient.
Spatial distribution and determinant factors of Female Genital Mutilation among reproductive age women in Ethiopia, 2016; Based on Ethiopian National Demographic and Health Survey
Authors: Muluneh Atalay Goshu , Kassa Getahun Molla , Merid Mehari WoldeMariam
Published: March 2020

Background : Though condemned and considered as a crime by the countries government, Female Genital Mutilation (FGM) remains a common public health problem in Africa and Ethiopia as well. Thus, this study was aimed to assess the spatial distribution and associated factors of female genital mutilation in Ethiopia based on the Ethiopian demographic and Health survey 2016 data. Method: This is a secondary data analysis of Ethiopian Demographic and Health Survey (EDHS) 2016 data based on 7,163 women who were included for FGM interview. The data was weighted using sampling weight as recommended by the program. The MS excel and ArcGIS 10.3 softwares were used for data cleaning and spatial analysis respectively. Global and local level clustering was assessed. For the none spatial data and the determinant factors, data cleaning and analysis was done using STATA 14. Multi-level mixed effect logistic regression model was fitted. Variables with P-value <0.25 in the bi-variable analysis were fitted in the multi-variable analysis. Finally, variables with p-value <0.05 with 95% CI of adjusted odds ratio were reported as a statistically significant determinants of FGM. Result : Female genital mutilation was spatially clustered (Global Moran’s I: 0.46, p<0.001). Significant hot spot clusters were found in Amhara, Oromia, Southern Nations Nationalities and Peoples (SNNP) regions. Mothers age >30 (AOR=2.41, 95% CI: 1.78,3.26) years, never in union (AOR=0.31, 95%CI: 0.22, 0.44), currently not working (AOR=0.71, 95%CI: 0.55, 0.92), women who considered FGM to be continued (AOR=2.86, 95%CI: 1.75, 4.68), not heard of FGM (AOR=0.22, 95%CI: 0.08,0.62), had no formal education (AOR=1.67, 95% CI: 1.03, 2.71), muslim (AOR=3.90, 95%CI:2.5, 6.09) and protestant (AOR=1.76, 95%CI: 1.25, 2.97), and those who thought of FGM as required by religion (AOR=1.99, 95%CI: 1.31,2.99) were found to be significant determinants of female genital mutilation. Conclusion: Female genital mutilation was spatially clustered with hotspot areas located. in Amhara, Oromia, and SNNP regions . Age of the mother, religion, occupation, educational level, marital status, information about Female genital mutilation, and intention about FGM to be stopped or continued were significant determinants of female genital mutilation
Measuring the effectiveness of digital nursing technologies: Development of a comprehensive digital nursing technology outcome framework based on a scoping review
Authors: Krick Tobias , Huter Kai , Seibert Kathrin , Domhoff Dominik , Wolf-Ostermann Karin
Published: March 2020

Background: Digital nursing technologies (DNT) comprise an expanding, highly diverse field of research, explored using a wide variety of methods and tools. Study results are therefore difficult to compare, which raises the question how effectiveness of DNT can be adequately measured. Methods currently used might not be sufficient for certain specific nursing contexts. A comprehensive outcome framework that shows the multitude of possible outcome areas could be useful to generate more comparable results. The aim of the present study is to develop an outcome framework for DNT and to indicate which outcome areas have been most frequently evaluated in previous studies and how this has been done. Methods: We combined an inductive and deductive approach to develop the framework. The numerical analysis is based on a scoping review focussing on the effectiveness of DNT for persons in need of care, formal or informal caregivers or care institutions. Nine databases were included in the screening: Medline, Scopus, CINAHL, Cochrane Library, ACM Digital Library, IEEE Xplore, the Collection of Computer Science Bibliographies, GeroLit and CareLit. Additional literature searches and expert interviews were included. Results: The developed framework comprises four outcome target groups and 47 outcome areas. There are considerable differences in the researched outcome areas for the individual outcome target groups. Persons in need of care were by far the most frequently surveyed, particularly with respect to their psychological health. There are much fewer studies on formal and informal caregivers, and it is particularly noticeable that the quality of life of both groups has rarely been investigated. Care process quality was most frequently researched for organisations. Conclusion: We were able to provide a comprehensive DNT outcome framework, thereby identifying the outcome tools used and the less researched outcome areas. We recommend a detailed investigation of all areas and tools in future research projects with a view to initiating a discussion on the differing importance of existing outcome areas and on a standardisation of outcome tools. We also recommend the development of outcome areas for the macro level of effectiveness assessment. Keywords: Technology, Care, Nursing, Framework, Effectiveness, Effect, Digital, Outcome, Evidence
Relationship between Night shift work, Eating Habits and BMI among Nurses in Lebanon
Authors: Samhat Zeinab , Attieh Randa , Sacre Yonna
Published: March 2020

Background The objective of this cross-sectional study was to evaluate the relationships between night shift work, eating habits and body mass index (BMI) among Lebanese nurses. Methods A total of 307 nurses were randomly selected from five hospitals located in Beirut. Data about demographic and professional characteristics, anthropometric measures, dietary habits and intakes were collected through a validated questionnaire. To study the relationship between night shift work, eating habits and BMI, chi-square test, t-test and logistic regressions were used. Results The majority of nurses (78. 2%) had irregular meals timing with a significant decrease in the number of complete meals consumed during the day and an increase in the number of snacks consumed during night (p<0. 05). The most consumed snacks during night shifts were sweets and potato chips. The findings highlighted that BMI and waist circumference significantly increased with the number of years of work (r=0.175; p<0.05) and the cumulative number of night shifts hours over the entire work history (r=0.135/p< 0. 05). Conclusion : Night shift work is positively associated with abnormal eating patterns and BMI among Lebanese nurses. However the increase in BMI is not related to eating habits.
The Impact Of Frailty On Admission To Home Care Services And Nursing Homes: Eight-Year Follow-Up Of A Community-Dwelling, Older Adult, Spanish Cohort
Authors: Cegri Francisco , Orfila Francesc , Abellana Rosa M , Pastor-Valero María
Published: March 2020

Background

The aim of this study is to identify the factors that anticipate the future inclusion of community-dwelling individuals aged ≥ 70 years in home care programmes (HC) and nursing homes (NH), and to develop the corresponding prediction models.

Methods

Study design: prospective, multicenter, cohort study in 23 primary healthcare centers located in Catalonia, Spain, with an eight-year follow-up (2005-2013).

Participants: the cohort was made up of 616 individuals.

Data collection: baseline interview included a multidimensional assessment carried out by primary health care professionals. Outcome variables were collected during follow-up by consulting electronic healthcare records, telephone contacts, and the Central Registry of Catalonia for mortality.

Statistical analysis: a prognostic index for a HC and NH at eight years was estimated for each patient. Death prior to these events was considered a competing risk event, and Fine–Gray regression models were used. The internal validity of the predictive models was tested for 150 bootstrap re-samples.

Results

At baseline, mean age was 76.4 years, 55.5% were women, and 22% lived alone. During follow-up, 19.2% entered a HC program, 8.2% a NH, and 15.4% died without presenting an event. Of those who entered a NH, 31.5% had previously been in a HC program.

Multivariate competitive risk models for a HC and NH showed that the risk of a HC entry was associated with older age, dependence on the Instrumental Activities of the Daily Living, and slow gait measured by Timed-up-and-go test. An increased risk of being admitted to a NH was associated with older age, dependence on the Instrumental Activities of the Daily Living, augmented number of prescriptions, and the presence of social risk.

Conclusions

Prognostic models based on comprehensive geriatric assessments can predict the need for the commencement of HC and NH admission in community-dwelling older adults. Our findings underline the necessity to measure functional capacity, mobility, number of prescriptions, and social aspects of older adults in primary healthcare centers. In such a setting they can be offered longitudinal holistic assessments so as to benefit from preventive actions in order to remain independent in the community for as long as possible.
Higher fatty liver index is associated with increased risk of new onset heart failure in healthy adults: A nationwide population-based study in Korea
Authors: Roh Jae-Hyung , Park Jae-Hyeong , Lee Hanbyul , Yoon Yong-Hoon , Kim Minsu , Kim Yong-Giun , Park Gyung-Min , Lee Jae-Hwan , Seong In-Whan
Published: March 2020

Background Heart failure (HF) is relatively common cardiovascular disease with high mortality and morbidity. Although it is associated with many cardiovascular risk factors, the association between nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, and HF has not been evaluated in a large-scale cohort study. Thus, we evaluated the ability of the fatty liver Index (FLI), a surrogate marker of NAFLD, to predict the development of HF in healthy individuals.
Methods We evaluated 308,578 healthy persons without comorbidities who underwent the National Health check-ups in the republic of Korea from 2009 to 2014. The association between the FLI and HF was analyzed using multivariate Cox proportional-hazards models.
Results During a median of 5.4 years’ follow-up, 2,532 subjects (0.8%) were newly diagnosed with HF. Subjects were categorized into quartile groups according to FLI (Q1, 0-4.9; Q2, 5.0-12.5; Q3, 12.6-31.0; and Q4, >31.0). The cumulative incidence of HF was significantly higher in subjects with the highest FLI than in those with the lowest FLI (Q1, 307 [0.4%] and Q4, 890 [1.2%]; P<0.001). Adjusted hazard ratios (HRs) indicated that the highest FLI was independently associated with an increased risk for HF (HR between Q4 and Q1, 2.709; 95% confidence interval=2.380-3.085; P<0.001). FLI was significantly associated with increased risk of new-onset HF regardless of their baseline characteristics.
Conclusions Higher FLI was independently associated with increased risk of HF in healthy Korean population.
­Transcriptome profiling of non-climacteric ‘Yellow’ melon during ripening: insights on sugar metabolism
Authors: Schemberger Michelle Orane , Stroka Marília Aparecida , Reis Letícia , Los Kamila Karoline de Souza , de Araujo Gillize Aparecida Telles , Sfeir Michelle Zibetti Tadra , Galvão Carolina Weigert , Etto Rafael Mazer , Baptistão Amanda Regina Godoy , Ayub Ricardo Antonio
Published: March 2020

Background: The non-climacteric ‘Yellow’ melon ( Cucumis melo , inodorus group) is an economically important crop and its quality is mainly determined by the sugar content. Thus, knowledge of sugar metabolism and its related pathways can contribute to the development of new field management and post-harvest practices, making it possible to deliver better quality fruits to consumers. Results: The RNA-seq associated with RT-qPCR analyses of four maturation stages were performed to identify important enzymes and pathways that are involved in the ripening profile of non-climacteric ‘Yellow’ melon fruit focusing on sugar metabolism. We identified 895 genes 10 days after pollination (DAP)-biased and 909 genes 40 DAP-biased. The KEGG pathway enrichment analysis of these differentially expressed (DE) genes revealed that ‘hormone signal transduction’, ‘carbon metabolism’, ‘sucrose metabolism’, ‘protein processing in endoplasmic reticulum’ and ‘spliceosome’ were the most differentially regulated processes occurring during melon development. In the sucrose metabolism, five DE genes are up-regulated and twelve are down-regulated during fruit ripening. Conclusions: The results demonstrated important enzymes in the sugar pathway that are responsible for the sucrose content and maturation profile in non-climacteric ‘Yellow’ melon. New DE genes were first detected for melon in this study such as invertase inhibitor LIKE 3 ( CmINH3 ), trehalose phosphate phosphatase ( CmTPP1 ) and trehalose phosphate synthases ( CmTPS5 , CmTPS7 , CmTPS9 ). Furthermore, the results of the protein-protein network interaction demonstrated general characteristics of the transcriptome of young and full-ripe melon and provide new perspectives for the understanding of ripening.
Empirical development of a typology on residential long-term care units in Germany - results of an exploratory multivariate data analysis
Authors: Bergmann Johannes Michael , Ströbel Armin Michael , Holle Bernhard , Palm Rebecca
Published: March 2020

Background Organizational health care research focuses on describing structures and processes in organizations and investigating their impact on the quality of health care. In the setting of residential long-term care, this effort includes the examination and description of structural differences among the organizations (e.g., nursing homes). The objective of the analysis is to develop an empirical typology of living units in nursing homes that differ in their structural characteristics. Methods Data from the DemenzMonitor Study were used. The DemenzMonitor is an observational study carried out in a convenience sample of 103 living units in 51 nursing homes spread over 11 German federal states. Characteristics of living units were measured by 19 variables related to staffing, work organization, building characteristics and meal preparation. Multiple correspondence analysis (MCA) and agglomerative hierarchical cluster analysis (AHC) are suitable to create a typology of living units. Both methods are multivariate and explorative. We present a comparison with a previous typology (created by a nonexplorative and nonmultivariate process) of the living units derived from the same data set. Results The MCA revealed differences among the living units, which are defined in particular by the size of the living unit (number of beds), the additional qualifications of the head nurse, the living concept and the presence of additional financing through a separate benefit agreement. We identified three types of living units; these clusters occur significantly with a certain combination of characteristics. In terms of content, the three clusters can be defined as: "house community", "dementia special care units” and "usual care". Conclusion A typology is useful to gain a deeper understanding of the differences in the care structures of residential long-term care organizations. In addition, the study provides a practical recommendation on how to apply the results, enabling housing units to be assigned to a certain type. The typology can be used as a reference for definitions.