bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of Patients With Advanced Melanoma
Authors: Boland Genevieve
Published: June 2022

For treatment of melanoma, accumulated research has allowed the transition of the most effective treatments into earlier stages of disease management. To this end, immunotherapy has become approved for high-risk stage II and resected stage III melanoma, and is currently being evaluated in the neoadjuvant setting. BRAF/MEK-targeted therapy is also approved in the adjuvant setting and is being evaluated in neoadjuvant trials. In stage IV disease, the optimal sequencing of these 2 main approaches is with immunotherapy initiated first. Recently, the LAG-3 antibody relatlimab, in combination with nivolumab, has produced impressive responses with low toxicity and has become a new standard of care compared with anti–PD-1 monotherapy. As heterogeneity within disease stages has become better appreciated, staging and risk classification have been refined.
Updates in the Treatment of Patients With Colorectal Cancer
Authors: Krishnamurthi Smitha S.
Published: June 2022

A number of assays are now available to estimate the prognosis of early-stage colorectal cancer, including multigene assays, the Immunoscore, and circulating tumor DNA (ctDNA). Although the results of these assays may provide prognostic information regarding the risk for recurrence, their use as a predictive assay has not yet been validated. Therefore, although these assays may be useful for prognostication, further validation would be required to include in the NCCN Guidelines. For the treatment of metastatic colorectal cancer, major advances have included the use of checkpoint inhibition in metastatic disease. Studies are currently underway to further define their optimal use.
Management of Patients With Aggressive Nonmelanoma Skin Cancers
Authors: Thomas Valencia D. , Wong Michael K. , Bishop Andrew J.
Published: June 2022

Nonmelanoma skin cancers (NMSCs), which encompass a variety of cutaneous malignancies, are frequently managed with surgery, radiation therapy, cytotoxic chemotherapy, systemic immunotherapy, and active surveillance. In this tumor board–style forum, a panel of experts used several case studies as a basis to review these approaches and to describe existing clinical challenges. The current NCCN Guidelines for NMSC, which reflect the most up-to-date, evidence-based data relating to the evaluation and management of NMSCs, also provide key considerations and recommendations for the treatment of this patient population.
Pharmacogenetics in the Treatment and Supportive Care of Patients With Cancer
Authors: Craig David S.
Published: June 2022

For patients undergoing treatment for cancer-induced pain, the identification and evaluation of pharmacogenetic variability may improve outcomes. Metabolism of opioids and other analgesic agents is influenced by patient-specific variables and drug–drug interactions, which often pose clinical challenges. Consultation with a clinical pharmacist or pharmacogenetics specialist is recommended to aid in the interpretation and evaluation of pharmacogenetic test results. The current NCCN Guidelines for Adult Cancer Pain provide pharmacogenetic considerations and recommendations for the treatment and supportive care of this population.
Plenary Session—The Patient Journey: Equity of Cancer Care
Authors: Farrington Thomas A. , Margolies Liz , Chambers Shonta , Garcia-Jimenez Maria D. , Schatz Alyssa A. , Guerra Carmen E.
Published: June 2022

Although many people with cancer have benefited from the host of therapeutic and research advances across many different tumor types over the past decades. Not every patient with cancer is afforded the opportunity for such treatments, and there is an assortment of notable barriers to the delivery of equitable care for all. To address the complexity of this important issue in contemporary cancer care, a distinguished panel at the NCCN 2022 Annual Conference explored this topic from several different vantage points, including the patient perspective and the view from inside the LGBTQ+ community. In addition, several panel members explored the constructive steps and initiatives being taken in the clinical, research, and policy realms to improve access to care for all patients with cancer, as well as overall health equity.
Valoración aristotélico-argumentativa del caso Iguala, a propósito de la Comisión por la Verdad y la Justicia
Authors: Ramírez Daza y García Rómulo , Cruz Covarrubias Armando Enrique
Published: June 2022

En la presente investigación se analiza la fundamentación de la sentencia de amparo en revisión 203/2017 del Caso Iguala, en su resolución de conformar una comisión investigadora de la verdad y la justicia, para esclarecer y resolver el caso de los 43 desaparecidos. Desde la teoría aristotélica de la argumentación se busca estudiar la sentencia y decantar sus resultados lógico-argumentales a partir de dicho modelo hermenéutico. Finalmente, se evaluará su racionalidad de acuerdo con el paradigma tríadico: analítico-dialéctico-retórico que compone la lógica de Aristóteles, para ver si los argumentos presentados se justifican y convencen en sí mismos.
Del discurso de la domesticidad al feminismo de la corresponsabilidad: la contribución de Carmen de Burgos
Authors: Garibo Peyró Ana Paz
Published: June 2022

Algunas de las pioneras del feminismo permanecieron ancladas a lo que se ha venido llamando el discurso de la domesticidad, pues, no obstante sus reivindicaciones en favor de la igual educación de las mujeres, continuaron defendiendo la pertenencia de éstas al ámbito doméstico. Paulatinamente el movimiento feminista fue evolucionando y fraguó posteriormente en torno a la reivindicación del voto para la mujer y de derechos civiles y laborales hasta configurarse la primera ola feminista o feminismo de la igualdad. Es conocida la evolución que desde entonces han experimentado los diversos feminismos. Este proceso puede observarse en la obra de una de las primeras feministas españolas de inicios del siglo XX, Carmen de Burgos. Este trabajo se centra en el análisis del recorrido del pensamiento de esta autora en su tránsito por distintos discursos de género que evolucionó desde esa inicial postura centrada en la domesticidad hasta un pensamiento feminista que comparte ya rasgos con el llamado feminismo de la corresponsabilidad.
Dualidades y Contradicciones en los Planes de Estudio del Profesorado de Música. De la Reproducción Acrítica a la Justicia Social
Authors: Zamorano Valenzuela Felipe Javier , Aróstegui Plaza José Luis , González-Martín Cristina
Published: June 2022

En este artículo, se presenta una revisión de la literatura sobre los planes de estudios de formación del profesorado de Música de enseñanzas de régimen ordinario, a fin de hacer una reflexión crítica sobre qué se está haciendo y por qué en las aulas universitarias, qué teorías implícitas hay en los mismos y qué podría hacerse para mejorarlos. Tras el proceso de análisis, puede encontrarse una influencia de la lógica económica tanto en aspectos de fondo, que se manifiestan en disyuntivas entre cuestiones musicales y educativas, como de forma, debido fundamentalmente al Espacio Europeo de Educación Superior. Al final se concluye que, sin renunciar a los aspectos económicos, los planes de estudios deberían ir más encaminados hacia la integración del conocimiento pedagógico y musical, y el tratamiento de aspectos relativos a la justicia social si no queremos una reproducción acrítica de racionalidades a menudo obsoletas en la formación inicial del profesorado de Música.
NÚM. 49 (2022): REVISTA ELECTRÓNICA DE LEEME
Authors: Editorial Equipo
Published: June 2022

Número completo
Thinking as a function and its decomposition into a Taylor series
Authors: Strigin Mikhail
Published: June 2022

The paper hypothesizes the possibility of applying the mathematical construction of the Taylor series in the semantic space. Then symbolic forms, like some spiritual functions that display the immanent in semantic space and are explicated in the form of verbal constructions, can be tried to decompose into a Taylor series. The first terms of the Taylor series of thinking functions carry basic meanings that are conjectured by secondary forms, tertiary, etc., as in the case of the usual Taylor series, where the first term of the series is a constant, the second term is linear, determined by the first derivative of the function, the third is quadratic, otherwise acceleration. The paper shows that all of the above can be found in the paradigms of thinking called Foucault epistems. The world in ancient philosophy seemed unchangeable or cyclical, which refers us to the concept of a constant or the first term of the Taylor series of the function of thinking. With the advent of Christianity, the circle of time turned into a straight line, the concept of evolution appeared. This stage was completed by Galileo, who introduced the idea of speed into the paradigm of thinking, which completed the formation of the second, linear term of the Taylor series of the thinking function. The third term of the series appeared in Newton's theory and entered the next episteme with the idea of acceleration. Deductively, one can continue the decomposition of the thinking function into a Taylor series and imagine the appearance of a member of the series responsible for the third derivative.
Investigación anatómica del ápex cardíaco
Authors: Trainini Jorge , Beraudo Mario , Wernicke Mario , Carreras Costa Francesc , Trainini Alejandro , Mora Llabata Vicente , Lowenstein Haber Diego , Bastarrica María Elena , Lowenstein Jorge
Published: June 2022

Objective: Understanding cardiac anatomy is the key to solve unknown issues about its function. The continuous and helical myocardial structure plays a fundamental role in its torsion-detorsion motions. Does the apex, a constitutive part of the ventricle, have relevance in cardiac dynamics or is it simply a cul-de-sac? The aim of this study was to answer this question. Methods: Four young bovine and four human hearts (two embryos and two adults) were used for the anatomo-histological studies. Two procedures were carried out for this investigation: a) the continuous myocardium unfolding to observe the fiber arrangement at the tip of the left ventricle, called the apical zone; and b) horizontal and longitudinal sections to study the structure of the apex. The horizontal sections were performed between the middle 2/3 and the apex, and the longitudinal ones, sectioning left ventricular apex, with an apex-base orientation. Results: In all the human and bovine hearts studied we found that the apex corresponds only to the left ventricle, where the twist of the descending segment is located, in the ascending continuity of the myocardium. The apical cul-de-sac has practically no muscular plane at its end. It is internally lined by the endocardium and externally by the epicardium. The muscular plane has only 10% thickness of the adjacent myocardium, a structural concept confirmed by transillumination. Conclusions: The apex is a cul-de-sac practically devoid of muscle, in which the endocardium and epicardium are attached, but which performs the functions of supporting intraventricular pressures and being a constitutive part of the torsion and de torsion motions
Antiagregación en el síndrome coronario agudo sin elevación del segmento ST en adultos mayores - hipótesis popular age
Authors: Viruel Marcos , Muñoz Florencia , Garmendia Cristian , Parrilla Leandro , Ruano Carlos , Rivero Mirza , Zaidel Ezequiel , Lalor Nicolas , Pérez Gonzálo , Costabel Juan P.
Published: June 2022

Background: The POPular AGE study demonstrated that in patients over 70 years of age clopidogrel would be the P2Y12 receptor inhibitor (P2Y12i) of choice due to its association with lower bleeding incidence and no difference in ischemic events. Objective: We analyzed the safety and efficacy of different treatment regimens with P2Y12i, in patients ≥70 years with nonST-segment elevation acute coronary syndromes (NSTE-ACS) to test the “POPular AGE” hypothesis in the real world. Methods: This subanalysis of the prospective BUENOS AIRES I registry analyzed data corresponding to 1100 patients from 21 medical centers in Buenos Aires, Argentina, followed-up for 15 months. We considered the subgroup of patients ≥70 years, stratified according to the P2Y12i indicated at discharge. Results: This subgroup had a high burden of comorbidities, with 85.1% hypertension, 30.3% diabetes mellitus, and 43.2% chronic kidney disease. Patients treated with ticagrelor/prasugrel (n=54) presented with higher prevalence of active smoking, less atrial fibrillation and lower CRUSADE score, with no differences in the GRACE score, compared whit those treated with clopidogrel (n=286). At the 15-month follow-up, no significant differences were observed in the BARC ≥2 bleeding rate, with more events in the clopidogrel group (25.4% vs. 18.2%; p=0.327) and a benefit in the incidence of major adverse cardiovascular events (MACE) in the ticagrelor/prasugrel treatment group (18.6% vs 36.3%, p= 0.023). Conclusions: In adequately selected patients with NSTE-ACS ≥70 years, treatment with ticagrelor/prasugrel could be a safe and effective strategy
High Self-expandable Valve Implantation with the Cusp-Overlap Technique, a Strategy to Reduce the Need for Pacemaker in Transcatheter Aortic Valve Implantation. 30-day Outcome
Authors: Mendiz Oscar , Fava Carlos , Caponi Gaspar , Valdivieso Leon , Lev Gustavo , Gamboa Paul , Fraguas Hugo
Published: June 2022

Background: The aim of this study was to analyze whether higher transcatheter aortic valve implantation with self-expandable valves using the right and left cusp overlap strategy decreases the need for permanent pacemaker. Methods: A total of 164 consecutive patients undergoing TAVI with self-expandable valves were analyzed: 101 (61.6%) implanted with the conventional technique (CON) using the three-cusp coplanar view, and 63 (38.4%) using the right and left cusp overlap (COVL) technique. The primary endpoint (PEP) was the need for permanent pacemaker (PPM) at 30 days. Results: Mean age, prevalence of male gender, hypertension, prior coronary artery bypass graft surgery (CABG), and history of stroke, kidney function or hemodialysis was not different between groups. Patients in the COVL group had more diabetes, coronary percutaneous transluminal coronary angioplasty (PTCA) and prior infarct, and pre-TAVI PTCA was similar, with higher STS score (6.3±2.2 vs. 5.8±2.4; p=0.05). The presence of atrial fibrillation was greater in the COVL group, without differences in right or left bundle branch or atrioventricular block. There was no difference in aortic valve area, mean gradient and left ventricular ejection fraction. At 30 days, the need of PPM was significantly reduced with the COVL technique (6.3%% vs. 17.8%; p=0.03). No difference was observed in mortality, stroke, major bleeding, acute myocardial infarction or aortic regurgitation, and the presence of new-onset complete left bundle branch block was lower in the COVL group (4.8% vs. 12.9%; p=0.08). Conclusions: Use of the COVL technique, which allows higher self-expandable valve implantation during TAVI, was feasible and safe, decreasing the need for PPM without increasing complications
Atributos, puntuación y precios hedónicos en la Provincia de Buenos Aires y CABA
Authors: Cerimelo Manuela , Porto Natalia
Published: June 2022

Es un hecho conocido que las tarifas que cobran los alojamientos varían entre sí. Uno de los motivos es que los alojamientos difieren en atributos. Estos atributos incluyen no solo la calidad de la habitación, sino también el acceso a varias instalaciones compartidas, la calidad del servicio y la evaluación que hacen los consumidores. El enfoque de precios hedónicos permite estimar la disposición a pagar por las características del producto (alojamientos). Este enfoque establece que el precio de un producto puede considerarse como una función de los diversos atributos que tienen un precio implícito y pueden determinarse por separado. Teniendo en cuenta esta metodología y utilizando datos de dos sitios web turísticos, Booking y Airbnb, el objetivo de este trabajo es estudiar la influencia de una variedad de atributos sobre las tarifas cobradas por alojamientos en la Provincia de Buenos Aires (PBA) y la Ciudad de Buenos Aires. (CABA). Los resultados sugieren que la disposición a pagar en PBA por atributos más tradicionales (calefacción, aire acondicionado, etc.) es menor que la de específicos (deportes, spa, etc.). En CABA y PBA, se debe prestar atención a los atributos subjetivos ya que también tienen un impacto significativo en el precio.
Prevalence of HIV Infection among Blood Donors in a Tertiary Care Hospital of Haryana: A Retrospective Study
Authors: Singh Inderjeet , Chawla Bharti , Kumari Sneh , Jain RB , Chawla Sumit
Published: June 2022

Introduction: Blood is a scarce, but life saving resource. At the same time, unsafe transfusion practice also puts millions of people at risk of Transfusion Transmissible Infections (TTIs). Aim: To determine the prevalence and trend of blood borne infection namely Human Immunodeficiency Virus (HIV) among blood donors donating blood in a tertiary care hospital of Haryana, India. Materials and Methods: A retrospective study was conducted from September 2012 to August 2014 to calculate the prevalence and trend of HIV positivity among blood donors over a period of five years (2008-2012). Results were expressed in terms of frequency and percentage. Results: There were a total of 1,59,077 donations, including both voluntary and replacement donors. The overall prevalence of HIV infection among blood donors was found to be 0.26% over a period of five years (2008-2012). The HIV prevalence among blood donors showed an increased trend from 2008 (0.18%) to 2011 (0.34%), and then there was a dip in the year 2012 (0.23%). Conclusion: The number of female blood donors were less in comparison to male blood donor. The maximum number of donors were voluntary males followed by replacement males.
Large Mediastinal Mass Managed Conservatively in an Elderly Woman
Authors: . Dheeraj , Gupta Nitin , Kant Ravi , Pathania Monika
Published: June 2022

Mediastinal masses have been eluding clinicians for a long time, owing to their common symptoms that are attributable to common infective and non infective etiologies and their rare incidence. They are generally diagnosed in the anterior mediastinum and include a variety of different entities demonstrating a range of clinicopathologic features. Chest computed tomography is important for the diagnosis, to know the extent of disease and helps in the prognosis. The prognosis of mature teratoma is excellent, surgical removal is curative. This case report was of a 58-year-old female, an unusual age of presentation, diagnosed as benign mature teratoma and was managed conservatively with periodic assessment for symptomatology. A conservative rather than surgical approach was chosen keeping in mind the socio-economic profile of the patient, surgical complications, and benign nature of the disease. The uniqueness of our case is hidden behind the unusual presentation of the disease coupled with belonging to an eastern world where surgical modalities are not as accessible and affordable. Hence, a conservative approach might be an equally effective solution, especially considering the age of presentation.
Financial Distress and It’s Prediction: A Case Study of the Textile and Garment Industry
Authors: Muhani . , Molina . , Elwisam . , Meini Zumratul , Wiweka Kadek
Published: June 2022

Aims: The objective of this research is to glance at the projections of financial distress in the textile and garment sub-sectors listed on the IDX.

Methodology: The case study method is used in this study to employ the descriptive quantitative method approach. While the IDX is the source of the case study data, the purposive sampling method was used on the financial statements of textile and garment sub-sector companies in 2019 and the first quarter of 2020. While the cross-sectional method is used for case study analysis, or by comparing the Z-score (multiple discriminant analysis) that has been performed between one company and the standard zone that has been carried out simultaneously.

Results: This study discovered that the case study using multiple discriminant analysis models in the first quarter of 2020 shows a significant impact of Covid-19 on the financial condition of companies listed on the IDX in the textile and garment industry, with 88 percent of companies in a stress zone. This study also shows that both internal and external factors can lead to a company's demise. As a result, corporate financial management decision-making must consider the company's liquidity, debt proportion, and the efficient use of working capital.

Implication/Applications: The findings of this study can be useful not only for researchers, but also for practitioners who are interested in financial distress cases.

The Originality of the Study: One of the study's limitations is that the sample is still limited to the research scope, which only covers the two sectors. Furthermore, this study only employs a single model of financial distress. As a result, it is hoped that in the future, research will be conducted with various types of company sectors and using various financial distress models.
Economic Impact of Yam Value Chain in Nigeria
Authors: Yusuf Taibat Moji
Published: June 2022

This study analyzed the profitability and marketing margins obtained by actors at various nodes of the yam value chain; and examined the organizations of the value chain, linkages among the key actors as well as the challenges faced by actors in the value chain in Nigeria using Baruteen Local Government Area (LGA) of Kwara State as a case study. 120 respondents consisting of 40 producers, 20 processors, and 60 sellers were selected through a three-stage sampling technique and were interviewed accordingly using structured questionnaires. Data collected were analyzed with; descriptive statics, statistics budgetary, marketing channels and Chi-Square analyses. Findings revealed significant difference in the net income of the value actors, with the processors having the highest share 3,558,63statistics

0, followed by the marketing agents 1,426,497 and the least 26,773.34 by the producers. Marketing margins also differed markedly among the actors. Sellers had the highest marketing margin per kg of yam. The identified constraints affecting yam value chain were high cost of production, inadequate market information, storage facilities, transport facilities, record keeping, and unfavourable government policies. The study recommends the need to scale up level of awareness in the value chain among smallholder farmers
Macro Faunal Diversity in Date Palm Plantation Soils of Yola, Adamawa State, Nigeria
Authors: Gujja A. A. , Umar M. R. , Isa W. S. , Amshi A. M.
Published: June 2022

This research assessed the macro-faunal diversity in soil of date palm plantation of Modibbo Adama University, Yola, Adamawa State. Parameters evaluated included; assemblage and diversity of soil macro invertebrates based on growth performances of the date palm. The plantation was divided according to growth variabilities. Assessment of macro fauna species was carried out using plots of 20m × 20m which was randomly selected, using plots of 1m x 1m that where laid at each anger point,Top soil for biological assessment of soil samples, were collected using trowels at depths ranging from 0-30cm depth. The soil samples was immediately spread on board of about 60cm2 and sorted for the presence of macro fauna. Soil macro-invertebrates ‘identification and enumeration. Soil macro-invertebrate assemblage was analyzed for diversity indices of species using relevant formulae. Results showed a total of 648 macro fauna scattered within the study area. Seventeen (17) Families of macro fauna were also identified in the study. Lumbricus terrestris (earthworm), the Heterotermes species (termites) and those belonging to the Formicidae family (ants) were the groups having the highest number of individuals. Leading to the conclusion that soil Macro fauna were present in the study area. However, the numbers of macro fauna were very active in the date palm plantation soil. This is an indication that strong relationship exists between macro fauna-invertebrates the date palm trees.
Firstever Breeding Record of Painted Stork along with Greater Adjutant Stork in the Flood Plains of Kosi River in Bhagalpur, Bihar, India
Authors: Choudhary D. N. , Abdullah . , Mandal J. N.
Published: June 2022

Painted stork (Mycteria leucocephela) is a large resident wetland bird of stork family- Ciconidae and has been categorized as near threatened. A new nesting colony of wild Painted stork, breeding along with Lesser (Leptoptilos javanicus) and Greater Adjutant stork (Leptoptilos dubius) have been observed on the same nesting tree (Kadamb- Anthocephalus cadamba) at Bagritola village of Kadwa panchayat located on the flood plains of the Kosi river in district of Bhagalpur, Bihar, India. In October, 2015, a single nest and three Painted storks were observed (of which one bird was seen incubating) on a Kadamb tree in the village Bagritola. This breeding site was studied from October, 2015 to March, 2020 to observe the detailed nesting and breeding behaviors. From October, 2015 onwards a significant increase in the number of nests of Painted storks was recorded at the same breeding site and the storks adopted 2-5 separate but closely situated kadamb trees for nesting. In the month of September, 2017, two adjacent Kadamb trees were adopted by the Lesser and Greater Adjutant storks for nesting and they built two nests (one on each) Kadamb tree. In October, 2017, Painted storks also started to build their nest on the same trees which were already occupied by the Adjutant storks. From 2018 onwards, no nests of Lesser adjutant stork were observed and the Painted storks were found to breed along with Greater adjutant storks only, till the end of the study period i.e. March, 2020. Similar to the other two stork species, both the male and female Painted storks were sharing the process of nest building, incubation, nursing and guarding the chicks by rotation. Fragments of old branches of nearby trees as well as from abandoned nests were used for building the nests which were cushioned with the leaves. The Painted storks were successfully breeding along with the Greater adjutant storks on the same nesting trees peacefully without any obvious disturbances. The breeding season of Painted storks was observed to continue between October to March and their incubation period was estimated to range between 27-30 days. The breeding season of Lesser adjutant stork was observed to continue between mid-August to Feb whereas of Greater adjutant stork was observed between September to March with slight variation of 6-10 days in Bihar, India.
Exploiting Genetic Counseling as a Tool for the Analysis of Dissociative Behavior and Sub-normality from Conception to Birth among Maladjusted Blind, Deaf and Dumb Infants
Authors: Ekeng Effiom, Bassey , Arop Lucy Obil , Ngwu Maria Enemeba , Obi Florence Banku , Ubi Godwin Michael
Published: June 2022

This paper analyzes the dissociation behavior of children from pregnancy to birth and resultant sub-normality using genetic counseling in an attempt to mainstream children with birth disabilities and the challenges of the genetic counselor. Genetic counseling is a process of communication to provide information about a genetic condition, or inheritance, and support decision making and adjustment in families with the inheritance gene. It uses children that need special needs, the blind, deaf and dumb. Genetic counseling approach, re-affirmation, care and integration, and confidence-building institutionalized in school and family life remains some of the vital tools needed to support these children using genetic guidance and counseling as the best approach to adjusting the different maladaptive behavior of children. The genetic counseling approach includes information about the implications of testing positive for the genetic disorder, including the psychological impact and other consequences, whether to inform relatives of your intention to test, or not to test and the usual pattern of progression of the sub-normality identified tested for and its potential treatments. Thus, the paper seems to analyze sub-normality as classified within the adequacy of social adaptation. Analysis of dissociation behavior associated with sub mentality shows discouragement, contempt, and neglect from an early age, emotionally and maladjusted social growth. Therefore, the counselor must experience sub-normality by getting involved and clarifying their feeling toward the children with these disabilities.
Synthesis, Characterization and Antimicrobial Studies on Mn(II), Ni(II) and Co(II) Complexes of Amino Acid-Based Ligand
Authors: Danhalilu R. L. , Kankara I. A. , Uthman K. S.
Published: June 2022

Amino acid ligand derived from the condensation reaction of histidine and acetophenone and its Mn(II), Ni(II) and Co(II) complexes were characterized by solubility test, melting point / decomposition temperature, elemental analysis, UV-visible spectroscopy, molar conductance, FTIR spectroscopy and magnetic susceptibility. Elemental analysis indicated 1:2 metal:ligand ratio. Percentage yield of the ligand is 62.84% with a melting point of 188ºC. The percentage yields of the complexes were 89.98%, 57.64% and 81.82% for Mn(II), Ni(II) and Co(II) complexes respectively. The decomposition temperatures of the complexes were in the range of 208-222ºC, low molar conductance values of the complexes indicated their non-electrolytic nature. The values of the magnetic moments (5.9BM, 4.0BM and 4.3BM) showed that they are paramagnetic. The ligand and its complexes were tested against bacterial isolates; S. aureus & S. typhi and fungal isolates; C. albicans and A. flavus, using the disc diffusion method. The results indicated that the ligand and its metal(II) complexes exhibited activity at different concentrations against all the species tested.
Risk Assessment of the Fungicide Bontima with the Active Substances Cyprodinil and Isopyrazam
Authors: Sverdrup Line Emilie , Bjørge Christine , Eklo Ole Martin , Grung Merete , Källqvist Torsten , Klingen Ingeborg , Låg Marit , Rivedal Edgar , Ropstad Erik , Øvrebø Steinar
Published: June 2022

Bontima is a new fungicide containing the two active substances isopyrazam and cyprodinil. Bontima is a fungicide against the most important diseases in winter and spring barley. Isopyrazam is a new active ingredient with new mechanisms of action that may delay the development of fungicide resistance in treated crops. 

The risk assessment was finalized at a meeting May 29, 2012, by the Panel on plant protection products of the Norwegian Scientific Committee for Food Safety (VKM). 

The Norwegian Food Safety Authority would like, in this regard, an assessment of the following: 

The fate and behaviour in the environment and the ecotoxicological effects and risks with regard to the properties of Bontima and the active substances. The Panel is particularly asked to look at the following: o The persistence of isopyrazam and its metabolites. o The leaching potential of isopyrazam and its metabolites. 

VKM’s conclusion is as follows:  

Fate-related issues 

Isopyrazam is likely to be persistent in Norwegian soils with an associated risk of accumulation after repeated use. 

Isopyrazam exhibits low mobility in soil and is not expected to reach groundwater, however the two main metabolites are likely to exceed the EUs drinking water limit of 0.1 \(\mu\)g/L in groundwater.  

Since drainage and runoff, as well as drift, contributes to concentrations in surface water the risk assessment have to consider all these sources. In the EU DAR step 4 calculations, buffer zones of 20 m have been used to reduce runoff levels contributions by 80 %. VKM does not accept the use of these buffer zone modifications for Norwegian topographic conditions (with e.g. steeper agricultural areas). 

Risk to the environment 

There is minimal risk for toxic effects of isopyrazam to terrestrial organisms. 

For the aquatic compartment, there is a high risk for toxic effects of isopyrazam to aquatic organisms with the proposed application regime. This is based on calculations of runoff without buffer zone modifications, from which the resulting TER calculations show high risk of acute effects on fish and a medium risk of acute effects on invertebrates. A minimal risk for toxic effects was calculated for sediment dwelling organisms, aquatic plants, and algae.
Risk Assessment of the Pesticide Centium with the Active Substance Clomazone
Authors: Sverdrup Line Emilie , Bjørge Christine , Eklo Ole Martin , Grung Merete , Källqvist Torsten , Klingen Ingeborg , Låg Marit , Rivedal Edgar , Ropstad Erik , Øvrebø Steinar
Published: June 2022

Centium is a new product in Norway containing the active substance clomazone. The product is applied for use as a herbicide in potato, carrot, cabbage, brussel sprout, swedes, oil seed rape, pea and bean. The Norwegian Institute for Agricultural and Environmental Research recommend approval in potato, carrot, swedes and pea. They do not recommend approval in oil seed rape, cabbage and bean because of lacking documentation on efficacy. The Norwegian Scientific Committee for Food Safety (VKM) was asked by the Norwegian Food Safety Authority to perform a risk assessment on human health and environmental fate of the active substance and the product. The risk assessment of the product was finalized at a meeting May 18, 2011, by   VKM’s Scientific Panel on plant protection products (Panel 2). VKM Panel 2’s conclusion is as follows: 

 

The active ingredient clomazone is of moderate acute toxicity after oral and inhalation exposure and of low dermal toxicity. The product Centium is of low acute toxicity after oral exposure, by skin contact or by inhalation; however the product may contain a co-formulant, monomeric isocyanate, with sensitizing properties. Due to the lack of documentation on the monomer content, the Panel cannot evaluate the risk of sensitization. UK Poem model estimation of exposure show that exposure to operator is below AOEL and the health risk is therefore  minimal. 

The effects observed in the dog study were considered due to the exposure of clomazone and should therefore be used to determine the NOAEL value.  

The fertility index used in the two-generation study in rats is not considered relevant as a measure of critical effect. The Panel suggests to use 4000 ppm (354 mg/kg bw/day) which is the highest dose tested in the study. 

Dose dependent responses were not always evident in the rat teratology study, but significant effects were found at the two highest dose levels (300 and 600 mg/kg bw/day).  The observed effects were considered adverse. The proposed NOAEL of 100 mg/kg bw/day was therefore supported. 

The teratology study with rats is considered relevant for determination of acute reference   dose (ARfD) since skeletal malformations can be induced after short exposure  periods if the exposure is taking place during a sensitive period of foetal  development.  

The Panel also concludes that based on the results from modeling with MACRO (4.4.2) using the Nordic groundwater scenarios and the input parameters agreed upon in the EU there is a potential for contamination of groundwater exceeding the trigger value of 0.1µg/L for the active ingredient following prescribed usage.
Effect of FYM and Inorganic Fertilizers on Nutrient Content, Uptake and Quality Traits of Wheat (Triticum aestivum L.) under Indo-Gangetic Plain of Uttar Pradesh
Authors: Choudhary Lakshya , Singh K. N. , Gangwar Kritagya , Sachan Ravindra , Pandey Hanuman Prasad
Published: June 2022

A field trial was conducted on sandy loam soil having low status of organic carbon and accessible nitrogen, medium in accessible phosphorous and high in accessible potassium at pot house of department of Soil Science and Agricultural Chemistry of C.S.A.U.A&T, Kanpur (campus) under Indo-Gangetic Plain zone of Uttar Pradesh, amid Rabi season of 2018-19. The experiment comprised of 5 treatment combinations in randomized block design with four replications consisted of T1: [Control], T2: [100% RDF], T3: [75% RDF + FYM at 6 t ha-1], T4: [50% RDF + FYM at 12 t ha-1], T5: [25% RDF + FYM at 18 t ha-1]. Wheat variety PBW-343 was grown with the recommended agronomic practices. On the premise of the comes about exuded from the present investigation, it might be concluded that application of 25% RDF + FYM at18 t ha-1 significantly recorded maximum nutrient content viz. N, P and K content in grain is 1.97%, 0.25% and 0.36% respectively and N,P, and K content in straw is 0.32%, 0.064% and 1.76% respectively. Maximum nutrient uptake viz. N, P and K uptake in grain is 86.58 %, 10.77% and 5.85% respectively and N, P, and K uptake in straw is 22.98%, 4.16% and 1.76 % respectively. Among the quality traits maximum protein content (11.78 %) was also associated with application of 25% RDF + FYM at 18 t ha-1. The present investigation clearly points out the significance of balanced use of nutrients including FYM in wheat for improving the nutrient content and uptake indices and quality of wheat crop.
Determination of Optimal Doses of Plant Growth Regulators for In vitro Propagation of Four Potato Varieties (Solanum tuberosum) in Niger
Authors: Sani Daouda Ousmane , Razak Sani Daouda Abdoul , Nassourou Lawali Maman , Mouhamadou Mounkaila Boureima , Illiassa Soumaila Sounakoye , Moussa Barage
Published: June 2022

Aims: The main limitation of the production of potatoes (Solanum tuberosum L.) in Niger is the external dependence on the supply of quality seeds. In the context of a national potato seed system, one of the critical phases is the rapid in vitro multiplication of virus-free good quality potato plantlets. Fifteen hormonal combinations were formulated and tested to determine a suitable hormonal combination and optimum concentrations for the in vitro production of a high number of plantlets for four farmer-preferred varieties in Niger (ATLAS, PAMELA, STEMSTER and YONA).

Study Design:  A completely randomized design (CRD) was employed to reveal the performance of four potato varieties, as affected by fourteen combinations of NAA and BAP with four replications. Results of the study were subjected to the analysis of variance, and significant differences among treatments were determined using GENSTAT12.01. Segregation between means was made according to the Student Newman-Keuls test, at 5% threshold.

Place and Duration of Study: The experiment was carried out at the laboratory of Biotechnology and plant improvement of the institute of radio-isotopes in the University Abdou Moumouni of Niamey, in Niger (latitude 13°29' North and longitude 2°10' Est), for 28 days.

Methodology: Uninodal stem explants of in vitro plantlets were cultured on full-strength Murashige and Skoog media (MS) supplemented with fourteen different combinations of α-Naphthalene Acetic Acid NAA (0; 0.25; 0.50; 1.0; 2.0 mg/l) and Benzyl Amino Purine BAP (0; 0.25; 0.50 mg/l), for 28 days.

Results: Statistical analysis of the results showed that the variety and hormonal significantly influenced the height of the plant, the number of leaves and number of roots. Treatments with NAA alone without BAP stimulated rhizogenesis. From a NAA concentration of 0.25 to 0.5 mg/l there is a proliferation of the roots and from 1 mg/l there is an increase in roots length. PAMELA and ATLAS cultivars showed better root production.
The acyl‐CoA‐binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation
Authors: He Jiajia , Liu Ke , Zheng Shengnan , Wu Yifan , Zhao Chenhui , Yan Shuaijie , Liu Ling , Ruan Ke , Ma Xiaopeng , Fu Chuanhai
Published: June 2022

Mitochondria are involved in many cellular activities, including energy metabolism and biosynthesis of nucleotides, fatty acids and amino acids. Mitochondrial morphology is a key factor in dictating mitochondrial functions. Here, we report that the acyl‐CoA‐binding protein (ACBP) Acb1 in the fission yeast Schizosaccharomyces pombe is required for the maintenance of tubular mitochondrial morphology and proper mitochondrial respiration. The absence of Acb1 causes severe mitochondrial fragmentation in a dynamin‐related protein Dnm1‐dependent manner and impairs mitochondrial respiration. Moreover, Acb1 regulates the remodelling of lipid droplets in nutrient‐rich conditions. Importantly, Acb1 promotes cell survival when cells are cultured in nutrient‐rich medium. Hence, our findings establish roles of ACBP in regulating mitochondria, lipid droplets and cell viability.
When can model‐based estimates replace surveys of wildlife populations that span many discrete management units?
Authors: Priadka Pauline , Brown Glen S. , Fedy Bradley C. , Mallory Frank F.
Published: June 2022

Monitoring widely distributed species on a budget presents challenges for the spatio‐temporal allocation of survey effort. When there are multiple discrete units to monitor, survey alternatives such as model‐based estimates can be useful to fill information gaps but may not reliably reflect biological complexity and change. The spatio‐temporal allocation of survey effort that minimizes uncertainty for the greatest number of units within a budget can help to ensure monitoring is optimized.

We used aerial survey‐based population estimates of moose (Alces alces) across 30 Wildlife Management Units (WMUs) in Ontario, Canada to parameterize simulated populations and test the performance of different monitoring scenarios in capturing WMU‐specific annual variation and trends. Firstly, we tested scenarios that prioritized conducting a survey for a unit based on one of three management criteria: population state, population uncertainty or number of years between surveys. Also incorporated in the decision framework were WMU‐specific costs and annual budget constraints. Secondly, we tested how using model‐based estimates to fill information gaps improved population and trend estimates. Lastly, we assessed how the utility (based on minimizing population uncertainty) of using a model‐based estimate rather than conducting a survey was impacted by population density, severity of environmental stressors and years since the last survey.

Interval‐based monitoring that minimized the number of years between surveys captured accurate trends for the highest number of WMUs, but annual variation was poorly captured regardless of management criteria prioritized. Using model‐based estimates to fill information gaps improved trend estimation. Further, the utility of conducting a survey increased with time since the last survey and was greater for populations with low densities when the severity of environmental stressors was high, while being greater for populations with high densities when environmental severity was low.

Overall, the utility of aerial survey monitoring was strongly associated with WMU‐specific monitoring precision and the predictive power of model‐based estimates. If long‐term trends are evident, then there is greater value in using alternatives such as model‐based predictions to replace surveys, but model‐based estimates may be a poor substitute when there is strong annual variation and when using a simple model.
Meta‐Analyses on the Effects of Disease‐Modifying Antirheumatic Drugs on the Most Relevant Patient‐Reported Outcome Domains in Rheumatoid Arthritis
Authors: van den Dikkenberg Marijke , Luurssen‐Masurel Nathalie , Kuijper Tjallingius Martijn , Kok Marc‐Redwart , Hazes Johanna Maria Wilhelmina , de Jong Pascal Hendrik Pieter , Lopes‐Barreto Deirisa , Weel‐Koenders Angelique Elisabeth Adriana Maria
Published: June 2022

Objective

Whereas in the treatment of rheumatoid arthritis much evidence exists on the effects of current pharmacologic treatment on clinical outcomes, little is known about the effects on patient‐reported outcomes. This systematic review aims to evaluate the effects of disease‐modifying antirheumatic drugs (DMARDs) on the patient‐relevant domains of pain, fatigue, activity limitation, overall emotional and physical health impact, and work/school/housework ability and productivity.

Methods

A literature search was conducted to identify randomized controlled trials wherein registered DMARDs were compared with placebo or methotrexate and reported the effects on patient‐reported outcomes included in the International Consortium of Health Outcomes Measurement standard set for inflammatory arthritis. Random effects meta‐analyses using the standardized mean differences of change scores as the effect measure were performed for the domains of pain, fatigue, and activity limitation, comparing DMARDs with placebo and methotrexate. The other 2 domains were presented narratively.

Results

Across the 5 domains, 69 records belonging to 52 studies were identified. All meta‐analyses showed a decrease of burden when DMARDs were compared with placebo (standardized mean differences [95% confidence interval] in pain −0.80 [−0.99, −0.61], fatigue −0.48 [−0.64, −0.32], and activity limitation −0.56 [− 0.63, −0.49]) and when compared with methotrexate (−0.55 [−0.70, −0.41), −0.44 [−0.55, −0.33], and − 0.37 [−0.44, −0.30], respectively).

Conclusion

DMARDs decrease the burden in all the domains that are relevant to patients. Effect sizes may be influenced by DMARD type. Therefore, in the decision for rheumatoid arthritis treatment, patient‐reported outcomes should be taken into account.
Electrochemical Polishing: An Effective Strategy for Eliminating Li Dendrites
Authors: Shi Kaiyuan , Dutta Arghya , Hao Yu , Zhu Mengting , He Lingyan , Pan Yu , Xin Xing , Huang Liang‐Feng , Yao Xiayin , Wu Jinghua
Published: June 2022

Dendritic growth of lithium (Li) is well‐known to originate from deposition on rough and inhomogeneous Li‐metal surfaces, and has long been a central problem in charging lithium metal batteries. Herein, a universal strategy is proposed for dendrite suppression by both in situ and ex situ electrochemical polishing of Li metal from the corrosion science perspective. This polishing technique greatly smoothens the surface of the Li and dynamically regenerates a homogeneous solid electrolyte interphase film simultaneously during cell cycling, which suppresses the nucleation sites for dendritic Li and establishes an ideal matrix for even deposition of Li. As a result, the polished Li presents a stable voltage profile and high Li utilization in both the symmetric cells and the full cells coupled with LiNi0.8Co0.1Mn0.1O2 (NCM811) or LiFePO4. The long cycle life of polished Li electrodes clearly demonstrates a uniform dendrite‐free deposition of Li. This strategy shows a new direction to realize a uniform deposition of Li by providing a regenerative homogeneous Li‐surface during repeated cycling.
Shape‐ and Size‐Dependent Kinetic Ethylene Sieving from a Ternary Mixture by a Trap‐and‐Flow Channel Crystal
Authors: Dong Qiubing , Huang Yuhang , Hyeon‐Deuk Kim , Chang I‐Ya , Wan Jingmeng , Chen Changlin , Duan Jingui , Jin Wanqin , Kitagawa Susumu
Published: June 2022

Ethylene (C2H4) purification from multicomponent mixtures by physical adsorption presents a great challenge in the chemical industry. This work successfully uses the postsynthetic method of crystal transformation in boiling alkaline solution to synthesize a trap‐and‐flow channel crystal (namely NTU‐67), the flow channel of which provides an effective shape‐ and size‐dependent sieving path for linear molecules such as acetylene (C2H2) and carbon dioxide (CO2), while the adjacent channel possesses customized space for efficient molecular trapping. The three‐bladed array of the nanospace enables the crystal to afford a record productivity of C2H4 (121.5 mL g−1, >99.95%) from C2H2/CO2/C2H4 (1/9/90, v/v/v) mixtures in a single adsorption–desorption cycle under humid and dynamic conditions, even at a high temperature of 343 K and wide gas ratio. The molecular‐level insight and mechanism of the cooperative role of the trap‐and‐flow channel, found computationally and observed experimentally, demonstrates a new design philosophy toward extending the application boundaries of porous coordination polymers to further challenging tasks.