bluuebunny/crossref_metadata_2025 huggingface dataset:
HEKİMBAŞI ABDÜLAZİZ EFENDİ'NİN BAYÂTÎ NAKIŞ YÜRÜK SEMÂİ'SİNİN İNCELEMESİ
Authors: ŞENDURAN Fatma Münevver
Published: December 2021

Osmanlı döneminde hekimbaşılık görevinde bulunmuş olan bestekâr Hekimbaşı Azîz Efendi; gerek yaşamış olduğu dönem gerekse bulunduğu mevkî bakımından Türk Mûsıkîsi tarihinde önemli bir yere sahiptir. Hekimbaşı Azîz Efendi’nin günümüze ulaşan altı bestesi incelendiğinde Türk Mûsikîsi alanında üstün meziyetlere sahip olduğu açıkça görülmektedir. Bu araştırmada bestekârın şaheserlerinden biri olan Bayâtî Nakış Yürük Semâisi incelemeye tâbi tutulmuştur. Söz konusu eser hem nakış formunda olması hem de güftesi bakımından murabba niteliği taşıması sebebi ile orijinal bir nakış yürük semâi örneğidir. Bu çalışma dâhilinde eser, bu iki farklı biçim yönüyle de ele alınmıştır. Bilinen yürük semâi formundaki eserlere nispeten, bu eserin incelenmesi formun farklı bir yapısını ortaya koyması açısından önem arz etmektedir. Eser; form analizi ile birlikte, güfte, arûz, prozodi, makâm geçkileri ve usûl işleyişi yönleri ile de incelemeye tâbi tutulmuştur. Nitel bir inceleme olan bu araştırmada betimsel araştırma yöntemi kullanılmış ve eser analizi Serda Türkel Oter tarafından geliştirilen, güftenin temel alındığı yeni bir biçim analiz yöntemi ile incelenmiştir. Hâneler şeklinde bölümlere ayrılan eserin mısra sayıları ve terennümlerin kullanımları göz önünde bulundurularak biçim şeması hazırlanmıştır. İncelenen eserin en eski nüshaları karşılaştırılarak güfte ve ezgisel farklılıklarına dikkat çekilmiş ve yine en eski nüshaya bağlı kalınarak gerekli tahlillerin ardından yeniden notaya alınmış ve biçimsel analizlerine yer verilmiştir.
Perigonium color and the antioxidant capacity of cañihua (Chenopodium pallidicaule Aellen)
Authors: Callohuanca-Pariapaza Manuel Alfredo , Mamani-Mamani Evaristo , Mamani-Paredes Javier , Canaza-Cayo Ali William
Published: December 2021

Currently, it is necessary to know the content of bioactive compounds, one of them is the antioxidant capacity of food, which has nutritional importance and functional properties, since these components are natural and play an important role in the prevention and treatment of several diseases, including cancer. Therefore, the objective of the investigation was to determine the nutritional quality and the relationship between the color intensity of the perigonium and the antioxidant capacity of the Chenopodium pallidicaule (Ch. pallidicaule). As material of study, we used four accessions of Ch. pallidicaule with perigonia of defined colors such as light yellow, orange, purple and black. We developed the physical-chemical analyzes and the grain functional components in the Agroindustrial Engineering Laboratories of the National University of Altiplano Puno, and in the Laboratory of Chromatography and Spectrometry of the San Antonio de Abad National University of Cusco. The results were submitted to Pearson's correlation analysis, and they show that the flavonoid indices with the perigonium color intensity values express significant positive correlation. In addition, the antioxidant capacity equivalent to Trolox was significantly different between the perigonium color intensities, where the accession with black perigonium turns out to be the one that reached the highest value (5g eq. Trolox/100g sample). We conclude that the color of the perigonium exhibited antioxidant capacity, which kept a direct correlation with the flavonoid content.
Gobernanza de ciudades intermedias: aprendiendo de acciones post-desastre en la zona Metropolitana de Acapulco, México
Authors: Becerril Hector , Rodríguez-Cortés Luisa Fernanda , Yañez-Soria Karol
Published: December 2021

This article analyses the governance patterns of post-disaster public action carried out after Hurricanes Ingrid and Manuel hit Coyuca de Benítez in 2013, a municipality that is part of the Metropolitan Area of Acapulco, Mexico, seeking to contribute towards broadening knowledge about the modes of governance of intermediate cities, and in particular, those related to disaster risk reduction. Conceptually, the concept of adaptive governance is presented to contrast and reflect on prevailing governance patterns in Coyuca. Methodologically speaking, this work is based on the sociology of public action, to analyse the reconstruction processes of infrastructure, public services, and housing, through interviews, focus groups, and diverse written sources. This paper argues that, despite the decentralization and democratization efforts of recent decades, governance patterns are highly centralized and not very adaptive, limiting the development of participatory and articulated interventions that meet people's daily needs and improve their quality of life. In this context, public action, rather than reducing disaster risks, has increased and/or generated new risks in already precarious and vulnerable urban territories. Along the same vein, this paper questions the relevance of regulatory and conceptual frameworks, such as adaptive governance, to guide significant changes, given the distance between ideal and existing governance patterns in the territories.
Gentrificación en el centro Metropolitano de Monterrey, 2010-2020
Authors: Campos-Sánchez Luis Fernando , Trevino Jesus A.
Published: December 2021

The purpose of the study is to identify areas that are possibly gentrified or in the process of being gentrified, through a localized typology of two components: youthification and an increase in the quality of life. This typology can be applied in similar investigations. Thisd paper addresses the case study of the Metropolitan Center of the City of Monterrey (CMM), Nuevo León, Mexico. The current urban regeneration plans and the increase of housing density in the CMM have caused a vertical real estate “boom” of apartment buildings and have strengthened the emergence of gentrification in the area, understood here as the decrease in social backwardness (increase in the quality of life) over time, with an increase in young adults (25 to 34 years-old), compared to older adults (60+ years-old). This article suggests a procedure to measure gentrification by overlapping the Index of Social Backwardness (ISB) at the Basic Geostatistical Area (AGEB) level, with a youthification index at the electoral section level between the 2010-2020 period. Both the decline of social backwardness (2010-2020) and youthification (2010-2020), are analytically articulated for successive census years, to generate a localized typology of the gentrification process.
Vivienda para estudiantes indígenas: permanencia, representatividad y proceso de proyecto participativo
Authors: Socas-Wiese Ricardo , Machado Eneldo Fernanda , Hammerschmitt da Veiga Alice
Published: December 2021

This article presents the project process adopted for the design of indigenous student housing at the Federal University of Santa Catarina, Brazil, and discusses its impact both on the formative process of architecture and urbanism students, regarding the experiences of indigenous students at the University. Aside from the relevance of that architecture as support for the permanence of students in public higher education, its importance as a symbol of shelter and respect for indigenous peoples at the university stands out. For this purpose, a participatory project was built that began with dialogues stages with indigenous students at the university and interactions with one of the ethnicities involved in its traditional territory (its village), for the definition of project guidelines and the needs’ program. Subsequently, for the proposal’s presentation and discussion, experiences were gathered in the proposed area for the project’s implementation and the physical models and drawings were presented, which were used to facilitate dialogue and participation of Indigenous students in the project process. The article presents the path followed, the spatial results of this process, the perceptions of the future users of the space, and reflections on the importance of outreach actions in the training of professionals in the area of architecture and urbanism, valuing the social role of the profession, and building a more sensitive projective repertoire, prepared to consider the human diversity that contemporaneity constitutes.
Condições de higiene bucal de idosos residentes em instituições geriátricas de pequeno porte em Porto Alegre
Authors: Mello Ana Lúcia Schaefer Ferreira de , Padilha Dalva Maria Pereira
Published: December 2021

Following the population-aging phenomenon, the number and the demands for nursing homes is increasing. Generally, oral health condition of institutionalized elderly people is poor and the maintenance of good patterns of oral hygiene is a problem. The aim of this study is to describe the oral hygiene conditions of elderly people who live in small (< 20) nursing homes of Porto Alegre-RS and to establish the relationship with independents variables: sex, age, time of institutionalization and level of dependence of the residents and number of care givers and price charged by the institutions. Oral hygiene conditions were verified through dental and denture plaque index. The mean obtained to teeth plaque scores was 2.24 (Sillnes and Löe index) and on dentures was 7.14 (Ambjornsen index). The poor oral hygiene condition is prevalent on the examined population when analyzed the independent variables sex, age, time of institutionalization, price, and number of caregivers because it was not demonstrated statistical significance related to the presence or the quantity of plaque on teeth and dentures (p>0,05). The level of dependence was the variable that presented statistical signficant (p=0,024). Independent elders showed lower means of dental plaque when compared to the moderate dependent or dependent elders. It is concluded that oral hygiene condition of this institutionalized elderly people is poor and need multidisciplinary and interinstitutional actions to revert this frame of continued neglect.
Threshold analysis of particulate matter emissions from biological soil crusts and their proportion in total wind erosion
Authors: Wang Yusong , Wang Dandan , Yu Xinxiao , Jia Guodong , Chang Xiaomin , Sun Lele , Zheng Pengfei , Qiu Yunxiao
Published: December 2021

The problem of farmland degradation and air pollution caused by wind
erosion and particulate matter emissions is serious. Relying on
biological soil crust coverage can effectively inhibit the production of
wind erosion materials. However, recent studies have discussed the wind
erosion and particulate matter emission processes separately and few
studies analyzed both, clarifying the changes in the proportion of
particulate matter emissions in the total wind erosion. Aiming at the
typical farming-pastoral transition zone in the monsoon climate zone,
this study used wind tunnels to analyze the wind erosion and particulate
matter emissions of algae crusts and moss crusts for different wind
speeds and coverage conditions. Results show that the effects of wind
speed and coverage on the total wind erosion of biological soil crusts
are similar. However, the emission of particulate matter is particularly
sensitive to coverage of biological soil crusts. The proportion of
particulate matter emissions in wind erosion decreases with increasing
wind speed. According to the trend of the proportion with wind speed,
the particle emission capacity of moss crust is directly proportional to
the particle size and inversely proportional to the coverage. In
contrast, the particle emission capacity of algae crust particles is
proportional to the particle size, but the relationship with coverage is
not regular. The results of this study can improve the knowledge of the
relationship between wind erosion and particulate matter emissions and
give relevant information for the management of wind erosion and
particulate matter emissions.
Čovjek, okoliš, prirodne pojave i kuga u Slavoniji i Srijemu tijekom XVIII. stoljeća
Authors: Maksić Veljko
Published: December 2021

Slavonija i Srijem, kao pogranična područja
Dunavske Monarhije, kroz čitavo XVIII. stoljeće su bili izloženi osmanskoj
ugrozi, ali i prodoru kuge preko sanitarnog kordona. Iako se kuga više puta
javljala u neposrednoj blizini Slavonije i Srijema, nije uvijek prešla državnu
granicu. No, uz sve mjere, zaraza je nekoliko puta pronašla put do
slavonsko-srijemskog prostora tijekom XVIII. stoljeća. Nameće se pitanje kakvi
to uvjeti moraju vladati da bi se kuga pojavila i održala na određenom
prostoru. Cilj rada je predstaviti uvjete na slavonsko-srijemskom prostoru u
kojima se kuga javljala tijekom epidemija tzv. erdeljske i iriške kuge. Kako je
za razvoj epidemije neke bolesti važna kolektivna otpornost, najprije je
napravljen kratki osvrt na imunitet Slavonaca i Srijemaca. Na to se nadovezuje osvrt
na smrtnost u odnosu na spol. Imunitet predstavlja proizvod brojnih čimbenika,
među kojima su ishrana i gladovanje. Upravo su ta dva čimbenika posebno
predstavljena u radu. Za razvoj bakterija i njihovih prijenosnika moraju se
osigurati određeni uvjeti u okolišu, koji su predstavljeni u cjelinama o vremenskim
uvjetima i čovjekovu okolišu. Nadalje, važnu ulogu u širenju epidemije imaju
prijenosnici, pa je posebna pažnja posvećena životinjama koje su dovedene u
korelaciju s kugom. S obzirom na to da su brojni suvremenici dovodili pojavu
kuge u korelaciju s potresom. dat je poseban osvrt na ove dvije pojave u
Slavoniji i Srijemu tijekom XVIII. stoljeća.
Mijat Stojanović – od „magareće klupe“ do istaknutog pedagoga i pučkog pisca 19. stoljeća
Authors: Švoger Vlasta
Published: December 2021

U radu će se analizirati javno djelovanje Mijata Stojanovića (1818.-1881.) na političkom,
pedagoškom i publicističkom polju. Bio je jedan od najistaknutijih hrvatskih
pučkih pisaca, učitelja i pedagoga u 19. stoljeću. Znanja stečena cjeloživotnim
samoobrazovanjem prezentirao je u učionici, na stručnim skupovima učitelja, u
knjigama namijenjenima puku, školskim udžbenicima i u brojnim člancima u
političkim listovima i stručnim časopisima. U njima je pisao o ulozi škola u
društvu, raznim pedagoškim pitanjima, praktičnim savjetima o gospodarstvu i
političkim temama. Preveo je i nekoliko pedagoških priručnika istaknutih
stranih pedagoga. Svojim javnim djelovanjem pridonio je transferu ideja i
znanja iz drugih europskih zemalja i njihovoj recepciji u Hrvatskoj na
političkom i pedagoškom polju.
Teniases caused by Taenia asiatica, Taenia saginata, Taenia solium
Authors: Chuelov S. B. , Rossina A. L.
Published: December 2021

The urgency of the problem of human teniases is due to the widespread prevalence of these parasitoses, which often infect humans.

The aim and result of the work is to summarize the available information about the etiology, epidemiology, pathogenesis, clinical picture, diagnosis, etiotropic therapy and prevention of human teniases.

Conclusion. Teniases are widespread, including on the territory of Russia. The clinic mainly includes symptoms of lesions of the gastrointestinal tract, allergic reactions. Diagnostics is carried out on the basis of the detection of eggs, proglottids, coproangigens of parasites in the feces, serological and molecular genetic tests. Praziquantel is an effective etiotropic therapy. Prevention takes into account the peculiarities of the epidemiology of teniases.
Catching lightning in a bottle: Surveying plagiarism futures
Authors: Dixon Zachary , George Kelly , Carr Tyler
Published: December 2021

The digitization of higher education is evolving academic misconduct, posing both new challenges to and opportunities for academic integrity and its research. The digital evidence inherent to online-based academic misconduct produces new avenues of replicable, aggregate, and data-driven (RAD) research not previously available. In a digital mutation of the misuse of unoriginal material, students are increasingly leveraging online learning platforms like CourseHero.com to exchange completed coursework. This study leverages a novel dataset recorded by the upload of academic materials on CourseHero.com to measure how at-risk sample courses are to potential academic misconduct. This study’s survey of exchanged coursework reveals that students are sharing a significant amount of academic material online that poses a direct danger to their courses’ academic integrity. This study’s approach to observing what academic material students are sharing online demonstrates a novel means of leveraging digitized academic misconduct to develop valuable insights for planning the mitigation of academic dishonesty and maintaining course academic integrity.
Hybrid Flexible Instruction: Exploring Faculty Preparedness
Authors: Romero-Hall Enilda , Ripine Caldeira
Published: December 2021

The aim of this investigation was to survey faculty members on their perceived level of preparedness to design and implement hybrid flexible (HyFlex) instruction. Participants included 121 full- and part-time faculty. Using an electronic survey, faculty members: a) rated their preparedness to engage on different HyFlex instruction competencies, b) shared which pedagogical strategies they felt prepared to use in this instructional modality, and c) listed the resources and support that they felt were needed to successfully implement their course. The results indicated that faculty members felt prepared to successfully engage in competencies related to HyFlex instruction that were significantly similar to competencies required for in-person instruction. However, they admitted to feeling less prepared to manage the intricacies that are unique to the HyFlex modality. Also, instructors believe a variety of pedagogical strategies can be integrated into HyFlex instruction; however, for those unfamiliar with this instructional modality, significant support and resources are needed before designing and implementing a course.
Does Mode of Access Make a Difference? Mobile Learning and online student engagement
Authors: Nichter Sarah
Published: December 2021

Even though student use of mobile devices for educational purposes has increased in recent years, the research on the possible impact on student success or engagement has been minimal. This study investigated the impact of mobile device use on student engagement and student success in online courses. The theory of Self-Regulated Learning (SRL) was a foundation for understanding and measuring engagement behaviors of online students. The Online Self-Regulated Learning Questionnaire (OSLQ) was the basis of the survey instrument. Participants were categorized into three groups of mobile device use (low, moderate, high). These three groups were used for comparison in each of the research questions. The research questions ask what impacts mobile learning has on student engagement, as measured with SRL; what impact mobile learning has on the SRL constructs of environment structuring, task management, and time management; and what associations mobile learning might have with student success and persistence. The ANOVA showed that mobile learning had a moderate impact on engagement for students in the high group. Students in each group engaged in environment structuring behaviors more than task strategies or time management behaviors. Students in the moderate and high groups engaged in task strategies more than the low group. Students in the high group engaged in time management behaviors more than the other groups.  The Crosstab analysis did not show an association between levels of mobile learning and course grade or persistence. These findings have positive implications for online pedagogy and course design.              Keywords: Mobile Learning; online learning; student engagement; Self-Regulated Learning; student success
Understanding the Roles of Personalization and Social Learning in a Language MOOC Through Learning Analytics
Authors: Jitpaisarnwattana Napat , Reinders Hayo , Darasawang Pornapit
Published: December 2021

In the last decade, there has been a great deal of interest in language MOOCs (LMOOCs) and their potential to offer learning opportunities for large audiences, including those in disadvantaged communities. However, experiences and research have shown MOOCs to suffer from several challenges. Chief among these have been low participation and completion rates, which are often attributed to limitations in how opportunities for personalisation and social interaction are implemented. For the current study, a dedicated LMOOC was designed and implemented, called the “Social and Personal Online Language Course (SPOLC).” This language learning environment incorporates a recommendation system and emphasizes personalisation and social interaction. The study identified the types of learning behaviour that were related to course completion and observed how 270 learners in the LMOOC used the various course features. The data were collected using learning analytical methods and analysed using binary logistic regression and feature extraction prediction model. The results demonstrated that working in groups and creating a learning plan were important factors associated with course completion, while interacting with other learners online was not. We conclude with several suggestions and implications for future LMOOC design, implementation, and research.
A Case Study of Learners’ Engagement in Mobile Learning Applications
Authors: Liu Chenxi , Correia Ana-Paula
Published: December 2021

Although mobile learning applications play a crucial role in today’s education and can support learning, the low retention rate is a prevalent challenge in mobile learning. Existing studies have found that interpersonal interaction, high expectations, and supportive environment (from an educational perspective) as well as compatibility, interactivity, and usability (from a marketing perspective) can impact learners’ engagement in learning activities and customers’ engagement in mobile applications. However, comprehensive studies investigating learners’ engagement in mobile learning applications from educational and marketing perspectives are rare. To fill the research gap, we analyzed learners’ reviews on five top-ranked lifelong learning applications (Udemy, LinkedIn Learning, Coursera, edX, and Skillshare). Inductive coding was used to identify critical factors impacting learners’ engagement in mobile learning applications, such as usability, availability of learning experiences, features to facilitate learning, interpersonal interaction, and incentives for completion. We further explored specific engagement strategies displayed in the analyzed applications through an analytical evaluation. Besides, this study expands Hew’s model of learners’ engagement and suggests new conceptual relationships between critical factors impacting learners’ engagement, self-determination theory, and learners’ engagement.
In Memorium: Dr. Karen Swan
Authors: Shea Peter
Published: December 2021

The community that makes up the Online Learning journal lost a colleague, leader, and dear friend recently.  Dr. Karen Swan, a founding member of the Online Learning Consortium and the James J. Stukel Distinguished Professor of Educational Leadership at the University of Illinois Springfield passed away on September 5, 2021.  Karen was a central figure on the editorial board of this journal and we will miss her wisdom, kindness, and spirit.
CHARACTERISTIC OF FREE-RADICAL DAMAGE AND ANTIOXIDANT PROTECTION STATE IN PATIENTS WITH CHRONIC KIDNEY DISEASE AGAINST A BACKGROUND OF MALABSORPTION SYNDROME
Authors: Shkarutyak А.Е.
Published: December 2021

Oxidation processes play an important role in damage of the renal structures, especiallyagainst a background of other serious pathologies, in particular, malabsorptionsyndrome.The study of the mechanisms of mutual aggravation and progression of kidneydamage against a background of malabsorption is a very urgent problem of the presenttime.Purpose - to investigate the state of free radical oxidation of lipids, proteins andantioxidant defense in patients with chronic kidney disease of different ages withoxaluria against a background of malabsorption syndrome.Material and methods. 98 patients with chronic kidney disease of the I-II stages(pyelonephritis) with the presence of oxaluria against a background of malabsorptionsyndrome of different age were examined.The age of the patients under examination was32 - 64. All patients underwent a study of the system of free radical oxidation of lipidsand proteins.Results. chronic kidney disease with the presence of oxaluria is accompanied by asignificant increase in the blood content of free radical oxidation products, namelyaldehyde and ketone dinitrophenylhydrazones, especially of a neutral nature,malondialdehyde, as well as a significant decrease in the indicators of the antioxidantdefense system, which manifested itself to a greater extent in patients with older age.groups.Conclusion. An essential factor in the development and progression of chronic kidneydisease with the presence of oxaluria against a background of malabsorption syndromeis an increase in the intensity of free radical oxidation of lipids and proteins (mainly dueto aldehyde and ketondinitrophenylhydrazones of a neutral nature).
LEFT VENTRICLE REMODELING IN PATIENTS WITH POSTINFARCTION CARDIOSCLEROSIS AND OBESITY, TAKING INTO ACCOUNT FABP 4 AND CTRP 3 LEVELS
Authors: Koteliukh M.Yu.
Published: December 2021

The objective – to study the structural-functional condition of the left ventriclemyocardium (LV) in patients with postinfarction cardiosclerosis and surplus body weighttaking into account the levels of adipokines FABP4 and CTR3.Material and methods. The study involved 189 patients. The first group consisted of60 patients with postinfarction cardiosclerosis, the second group included 68 patientswith postinfarction cardiosclerosis and excess body weight (EBW), the third groupcomprised 61 patients with postinfarction cardiosclerosis and obesity. The content ofFABP 4 and CTRP 3 was determined by enzyme-linked immunosorbent assay. Statisticalprocessing of the survey results was performed using the licensed software package“IBM SPPS Statistics 27.0”. According to the sample size and distribution of indicators,the parametric Student’s test was used. Evaluation of the significance of the differencebetween the means of multiple comparisons for quantitative traits with normaldistribution using Bonferroni correction was performed by one-way analysis of variance(ANOVA).The mean and the error of the mean were determinedThe correlations of theindicators were determined using the Pearson correlation coefficient (r). At a value ofp˂0.05, the difference was considered significant.Results. Patients with post-infarction cardiosclerosis and obesity in comparison withpatients without excess body weight were found to have an increase in end-systolicvolume (ESV), end-diastolic volume, end-diastolic size (EDS), end-systolic size (ESS),stroke volume, thickness of interventricular septum, thickness of the posterior wallof the left ventricle, size of the left atrium, mass of the left ventricular myocardium,LVMMI. A direct relationship between FABP 4 and ESS, ESV, LVMMI1in patients withpostinfarction cardiosclerosis and obesity was determined. There was a significantinverse correlation between CTRP 3 and EDS, ESS, ESV, LVMMI1 in patients withpostinfarction cardiosclerosisand obesity.Conclusions. The study showed that in patients with postinfarction cardiosclerosi 34sand obesity there was an increase in echocardiographic parameters. The influence ofFABP 4 and CTRP 3 content on the structural and functional state of the left ventricularmyocardium was determined.
CHALLENGES AND OPPORTUNITIES OF MEDICAL EDUCATION UNDER CONDITIONS OF CORONAVIRUS DISEASE (COVID-19) PANDEMIA
Authors: Poiasnyk I.M. , Gryb V.A.
Published: December 2021

The article analyzes how higher medical education is currently undergoing a gradual butsignificant change to the transformation into online learning adapt accordingly in orderto fulfill the core competencies of medical training and to provide quality education tomedical students during the COVID-19 pandemia.Objective – to study the challenges and opportunities faced by medical schoolsin introduction of the remote learning for basic science teaching in response to theCOVID-19 crisis.Conclusions. Despite the pace of this transition, both formal and informal studentfeedback indicated that students have an extremely high level of satisfaction andengagement with online learning activities. The use of emergent technology (e.g.,artificial intelligence for adaptive learning, virtual simulation, and telehealth) foreducation is most likely to be indispensable components of transformative change andpost-COVID medical education. These measures could then be followed by hands-onexperience that is provided in a safe environment. As physicians begin to use telehealth(phone calls, video visits, and communication over online medical record applications)to communicate with their patients, students should be included (and instructed) in thislearning environment. It is likely that telehealth will persist long after the pandemicrecedes perhaps even as a preferred method of physician-patient interaction in somesituations. Therefore, it is essential that students graduate from medical school welltrained in telehealth including technological aspects as well as learning the mostprofessional models of the physician-patient distance interaction.
Optimization of damaging perinatal factors diagnosing in intrauterine growth restriction
Authors: M. V. Маkаrenko  , О. A. Кuzmina
Published: December 2021

74 pregnant women with the symmetric form of intrauterine growth restriction (IUGR) at the term of pregnancy of 27-40 weeks were involved in the study. The conducted analysis showed that the principal cause of symmetric form of IUGR is the complicated course of pregnancy: gestosis (55 %) and protracted threat of pregnancy interruption (35 %). The obtained results allowed to distinguish the criteria of fetal chronic hypoxia and attribute them to the damaging perinatal factors in IUGR.
A case of late diagnosing dermal focal hypoplasia in a child
Authors: N. I. Pidvysotska  , I. V. Lastivka  , L. V. Boiko  , I. M. Valуhurskyі
Published: December 2021

Dermal focal hypoplasia is a rare X-linked dominant mesoectodermal disorder. The described case of Goltz’s syndrome shows clinical manifestations, a need for a multidisciplinary assessment, diagnostic and continuous monitoring of this pathology.
Specific characteristics of teaching pharmacology to foreign students under conditions of credit-module education system
Authors: I. B. Samura
Published: December 2021

The design of physician programs creates special challenges for providing pharmacology education. The article presents examples pertaining to improving teaching methods in pharmacology to foreign students at Medical Department. The paper has revealed peculiarities of theoretical knowledge and practical skills acquisition in the process of teaching pharmacology, and the stimulation technics for cognitive interest of students have been discussed. In particular, it has been analyzed the contributing factors that prove the need for the introduction and regular application of interactive teaching methods, testing students, the discussion of complex and unresolved scientific problems of dynamic and constantly developing science of pharmacology, and its interaction with other modern biomedical sciences.
The state of carbohydrate and lipid metabolism and glomerular filtration rate in patients with degree II hypertensive disease associated with type II diabetes
Authors: S. V. Biletskyi  , O. Z. Novytska  , O. A. Petrynych  , T. V. Kazantseva
Published: December 2021

The article deals with the state of carbohydrate and lipid metabolism, its interrelation with glomerular filtration rate (GFR) in patients with degree II hypertensive disease (degree II HD) associated with type II diabetes mellitus (insulin-independent DM). The patients being examined revealed hyperinsulinemia, insulin-resistance and dyslipidemia, which with concomitant type II DM are more pronounced. There is a tendency to hyperfiltration in patients with II degree HD and significant decrease of GFR with concomitant development of II degree HD and type II DM. disorders of lipid and carbohydrate metabolism in patients with II degree HD and concomitant type II DM are found to be as risk factors in the development of kidney afflictions.
Influence of vitamins C and E on lipid peroxidation processes and the activity of NO-synthase system in pancreas of rats with the epinephrine-induced stress
Authors: T. I. Bondarchuk
Published: December 2021

Influence of vitamins (Vit) C and E on the lipid peroxidation processes and activity of NO-synthase system in the pancreas of rats with the epinephrine-induced stress was studied. It was ascertained that Vit C decreased TBA-active products content as well as superdismutase activity more than Vit E under the same conditions. However the decrease of general NOS, eNOS activities and the content of NO2 - was more considerable in group with Vit E as compared to the action of Vit C. Both vitamins decreased the activity of iNOS equally. Combined action of Vit C and E under condition of epinephrine-induced stress reduced activity of general NOS and iNOS and the content of NO2 - more substantially from those treated with Vit independently, however there was no summation of their effects on studied processes.
Comparision influence of conditioned medium of human mesenchimal cells and interferon-α on development of tumor cell population
Authors: T. S. Herheliuk  , O. M. Perepelytsina  , M. V. Sydorenko
Published: December 2021

This work is a study of mediators and mechanisms of the effect of human mesenchymal stem cells from bone marrow (hMSC BM) on the tumor cell population line MCF-7 (breast adenocarcinoma). It is known that MSCs produce a wide range of cytokines and chemokines, and provide humoral cells interaction. BM MSCs produce tumor necrosis factor (TNF-α), interleukin (IL-1β, IL-2, IL-4, IL-6, IL-8), interferon-alpha (IFN-α). In this study we compared the proliferation, adhesion, survival and antigenic profile of breast adenocarcinoma cells that were cultured with conditioned medium (с-medium) of the MSC and IFN-α. Consequently, it was found that с-medium from MSC inhibited proliferation activity of MCF-7, increased cells adhesion, suppressed the ability to migrate, and reduced the expression of estrogen receptor and epidermal growth factor receptor. Conversely expression of cytokeratins increased, which is a positive sign for the tumor cells of epithelial origin. IFN-α showed a more pronounced effect on the tumor population. These findings suggest that cryopreserved MSC BM has antitumor activity. Also, our data suggest that IFN-alpha is one of the mediators of antitumor effect of MSCs.
Features of exercise induced bronchial asthma course in schoolchildren with polymorphisms in glutation-s-transferase genes
Authors: Koloskova O. K. , Hryhola O. G. , Bilous T. M. , Ortemenka Ye. P.
Published: December 2021

With respect to the principles of bioethics, on the base of allergy department of Chernivtsi Regional Children's Hospital it has been conducted a comprehensive clinical and paraclinical examination of 51 children with symptoms of exercise induced asthma phenotype depending upon the presence or the absence of genes polymorphism of the enzymes of glutation-S-transferase – GSTT1M1. The study showed that the course of the disease was more severe in the patients with deletions of the mentioned genes, though with more rapid effect of standard reliever treatments as compared to the patients with genotype GSTT1+M1+. The patients with exercise-induced asthma in the presence of deletion genes polymorphisms of GSTT1M1 (GSTT1delM1del, GSTT1+M1del or GSTT1delM1+) require a special attention to their environmental enhancement and normalization of their life-style.
Dynamic parameters of homeostasis under the influence of antiaggregant treatment in patients with atrial fibrillation and metabolic syndrome
Authors: M. A. Orynchak  , M. M. Vasylechko
Published: December 2021

The condition of coagulation and platelet hemostasis in 125 patients with atrial fibrillation (AF) and with metabolic syndrome (MS) has been analysed. Сoagulation and platelet hemostasis in 125 patients with AF and MS under treatment with acetylsalicylic acid (ASA) (group 1), omega-3 polyunsaturated fatty acids (omega-3 PUFAs) (group 2) and ASA with L-arginine (3 group) during 2 months were measured. It was established that omega-3 PUFAs are more effective compared with ASA/aspirin with L-arginine and it promotes normalization of fibrinogen, soluble fibrin-monomer complexes (SFMK), D-dimer and improves the platelet aggregative activity (PAA).
Some aspects of pathogenesis of erosive-ulcerous gastric lesions in liver cirrhosis patients
Authors: Palibroda N. M. , Fediv O. I.
Published: December 2021

Von Willebrand factor, tumor necrosis factor-α levels and portal bloodstream were examined in 47 patients with liver cirrhosis and 8 apparently healthy persons. The increase of von Willebrand factor and tumor necrosis factor-α levels were found to lead to the development of erosive-ulcerative lesions of gastric mucosa. The abnormalities of portal resistance, von Willebrand factor and TNF-α are interrelated data which play a certain role in occurrence of erosive-ulcerative lesions of gastric mucosa in patients with liver cirrhosis.
Comparative analysis of monocyesis and multiple gestation course after in vitro fertilization and embriotransfer
Authors: L. I. Sehedii  , О. I. Prokopiv
Published: December 2021

The data of comparative clinical and statistical analysis of gestation process and pregnancy outcome after IVF & ET in the observation period from 2008 through 2012 have been presented. For a set of initial parameters (age structure; cases, duration and infertility factors, the choice of controlled ovarian stimulation protocol) the studied groups did not differ. It has been concluded, that multiple gestation has a aggravating impact on pregnancies achieved in the result of IVF & ET, which was manifested in statistically more frequent, in comparison to monocyesis, cases of late miscarriage threat, intrauterine growth retardation of fetus (fetuses), preterm labour, adverse perinatal outcomes instances, which has been supported by the corresponding findings of the research in both monocyesis and multiple pregnancy groups. A substantial role in aggravating impact on pregnancy also refers to anemia, which statistically more frequently develops in women with a multiple gestation in comparison to those with monocyesis.
Enterobiasis caused changes in the mucous and skin of female genital tract
Authors: V. O. Skliarova  , K. I. Bodnia
Published: December 2021

The paper presents the changes in the skin of the external genitalia and perianal area, as well as in the mucous caused by enterobiasis. Enterobius vermicularis infestation has been identified in 60 % of patients with changes in the skin and mucous membranes. The influence of mature pinworms and their eggs on the vulva, causes a local reaction, which is accompanied by itching, discomfort, swelling, change in consistency and color of vaginal discharge. Only in 30 % of infected patients the complaint "night itch" was noted. Colposcopy changes of the vaginal mucosa and cervix have been detected in all women with enterobiasis.
Evaluation of control over the bronchial asthma in period of clinical well-being in teenagers depending on the severity of the bronchial inflammation
Authors: O. O. Shakhova  , I. B. Sichkar
Published: December 2021

At the basis of a complex examination of 63 adolescents it was revealed, that the signs of local inflammation in the bronchi and the increase of their nonspecific hyperresponsiveness remained in some of patients with asthma during the clinical well-being period with the absence of clinical symptoms. It was shown that the lower than 40.0 mmol/l content of nitrogen monoxide metabolites in the condensate of exhaled air increases the likelihood of retention of control: relative risk = 4,3 (while assessing the level of control by the ACT questionnaire) and 5,5 – in the evaluation of control level by the GINA questionnaire. Due to this the basic therapy is effective in almost every child, because the minimal number of patients needed to be treated to obtain a positive result is 1,3, according to ACT and GINA tests.
Statistical indicators of epidemiology of colorectal cancer among the population of Chernivtsi region, Ukraine and world
Authors: V. V. Shulhina  , O. I. Ivashchuk  , S. Y. Kravchuk  , I. Y. Hushul
Published: December 2021

Statistics indicators of prevalence, incidence and mortality caused by colorectal cancer in the population of the world, Ukraine and residents of Chernivtsi region with conducted taking into consideration patients’ gender and stage of disease.
Development peculiarities of uteroplacental blood flow in pregnant women with habitual noncarrying of pregnancy
Authors: L. V. Herman
Published: December 2021

The article presents the results of the study of are uteroplacental blood flow in pregnant women with noncarrying of pregnancy. The unfavorable factors of pregnancy progress have been studied.
Hormonal changes in women of late reproductive, perimenopausal and postmenopausal age with urogenital disorders
Authors: A. P. Hryhorenko  , O. G. Shymanska-Horbatiuk  , V. M. Kucheruk  , O. A. Poliovyi
Published: December 2021

Investigation of hormonal homeostasis in 51 women with urogenital disorders (urogenital prolapse, vaginal atrophy, urinary incontinence) and 10 healthy women (control group) was carried out. There was studied the concentration of pituitary-ovarian hormones, thyroid and adrenal glands hormones. The hormonal research showed a significant reduction of gonadotropins, prolactin, total testosterone, DHEA-S, cortisol in women of late reproductive age with urogenital disorders. In perimenopausal and postmenopausal women with urogenital disorders gonadotropins and TSH rates increased. Levels of prolactine, estradiol, progesterone, testosterone total, DHEA-S and cortisol reduced. In perimenopausal women with urogenital disorders level of total thyroxine (Т4) was significantly elevated.
The effect of rheosorbilact on the regulation mechanisms of sodium balance of sepsis patients
Authors: V. M. Konovchuk  , A. V. Andrushchak  , S. O. Akentiev
Published: December 2021

The article examines the effect of rheosorbilact on the regulation mechanisms of sodium balance of sepsis patients. It has been concluded that because of the filtration mechanisms damage the reduction of sodium filtration fraction is the result of the sodium balance impairment which is the component of ion-osmo and volume-regulative kidney function of severe sepsis patients.
Hemostatic system in chronic obstructive pulmonary disease with concomitant obesity
Authors: A. Y. Stupnytska
Published: December 2021

The examination of patients with chronic obstructive pulmonary disease with concomitant obesity established the presence of hypercoagulable changes, the severity of which depended on its degree. All this, along with the positive results of paracoagulation samples, increasing of soluble fibrin monomer complexes and early degradation products of fibrinogen in the blood, suggest the presence of chronic disseminated intravascular coagulation with prolonged retention of hypercoagulable in such pathology.
Analysis of modification of 6-year survival rate of the disabled due to acute myocardial infarction and stroke by clinical factors on the basis of Cox proportional hazards models
Authors: V. P. Klymeniuk  , O. M. Ocheredko
Published: December 2021

We have described the peculiarities of 6-year survival rate of the disabled due to acute myocardial infarction and stroke by the joint cohort of Zhytomyr oblast over 2007-2012. The cohort comprised 533 disabled people: 303 disability cases due to acute myocardial infarction (AMI) and 230 due to stroke. Survival rate data were compared to the results of foreign cohort studies. During the period of 6 years the survival rate was 79,5 % in AMI patients and 93,0 % in patients with stroke. The peculiarities of survival rate according to factors of medical care have been studied. Among others, timeliness of hospitalization significantly (р=0,036) modified lethality by 44 % in case of AMI and by 51 % in case of stroke. Comorbidity, measured by comorbidity Charlson’s index, significantly increased lethality by 69 % in patients with stroke only. From the list of prevalent drugs the significant impact on survival was rendered by β-blockers (р<0,0001) and reperfusion administered during the first 24 hours (р=0,012). Administration of aspirin, clopidogrel, nonfractioned heparin, statins, APF inhibitors failed to modify survival rate significantly.
Determination of traumatic process in open fracture of the long tubular bone diaphysis (cause-system analysis)
Authors: V. T. Voronov  , V. S. Dzhurabaiev  , A. I. Drevytskyi  , A. V. Sumlennyi
Published: December 2021

Deterministic relationships between the open fracture of the long tubular bone diaphysis and the consequences of the traumatic process were modeled. A cause-system approach to the investigation of deterministic complications of mechanical bodily injury was proposed. Causal estimations of determinants in open primary and open delayed fractures of the long tubular bone diaphysis are differentiated.
Comparative forensic analysis of gunshot injuries caused by 8x57mm cartridges equipped with GECO, RWS AND Sellier&Bellot expanding bullets
Authors: Bartoshyk Nataliia
Published: December 2021

The paper discusses the results of the experimental study of the gunshot injuries caused by 8x57mm cartridges equipped with expanding bullets from different manufacturers to biological and non-biological objects at various distances. Forensic description of the common and distinctive morphological features is presented.
Immunohistochemical researches for oncologic patients in forensic-medical and pathomorphological practice
Authors: Tumanskyi Valerii , Tumanska Liubov , Shavrin Volodymyr , Kurtiev Anatolii
Published: December 2021

The analysis of immunohistochemical researches, applied in pathomorphological differential diagnostics of malignant tumours in bioptats of the patients and in medico-legal practice for authentication of metastatic malignant tumours for suddenly dyings oncologic patients at which a malignant tumour was not diagnosed in the time of life is expounded in the article.
Legal and legislative study of biological objects be withdrawn from human corpse for scientific research in forensic medicine
Authors: Mishalov Volodymyr , Khokholieva Tamara , Yurchenko Volodymyr , Voichenko Valerii
Published: December 2021

Based on the analysis of changes in the new edition of the Criminal Procedural Code of Ukraine (2012) in combination with other applicable regulations, applicable to the forensics and legal status of the person who died, reasonable legal and legislative capabilities withdrawal (registration) parts of the body, organs and tissues, blood or other biological materials for scientific research in forensic medicine.