bluuebunny/crossref_metadata_2025 huggingface dataset:
Kebijakan Restrukturisasi Kredit Oleh Bank Terhadap Debitur UMKM Terdampak Langsung Maupun Tidak Langsung Pandemi Covid-19
Authors: Budihardja Georgius Ivan
Published: August 2022

AbstractThe Covid-19 pandemic is an outbreak of an infectious disease that has a major impact not only on health, but alsa on the social and economic sectors. Micro, small, and medium enterprises (MSMEs) are the types of businesses most affected by the COVID-19 pandemic, where the incoming income is not proportional to the espenses that must be paid, which consists of operational cost for employees, electricity, machinery and most business owners MSMEs lend money to banks for the purpose of capital and purchasing tools to support their business survival. Many MSME business owners experience this payment difficulty, especially payment of credit bills, even though it can be seen in fact that MSMEs are the largest economic supporting sector in Indonesia from the monetary crisis that hit Indonesia in 1998 until now, where the existence of MSMEs during the crisis continued to provide the impact of positive growth on Indonesia in any way, so the government should have provided a stimulus to save MSME debtors who were affected by the Covid-19 pandemic.Keywords: MSMEs Debitors; Covid-19 Pandemic; Force Majeure; Credit Restructuring; Banking.
AbstrakPandemi Covid-19 merupakan suatu wabah penyakit menular yang memberikan dampak besar tidak hanya pada kesehatan, tetapi berimbas pada sektor sosial dan perekonomian. Usaha mikro, kecil, dan menengah (UMKM) merupakan jenis usaha yang paling terdampak dengan adanya pandemi covid-19 ini, dimana pendapatan yang masuk tidak sebanding dengan pengeluaran yang harus diayarkan, yang terdiri dari biaya operasional pegawai, listrik, mesin dan kebanyakan pemilik usaha UMKM melakukan peminjaman uang kepada bank dengan tujuan untuk modal dan pembelian alat untuk menunjang kelangsungan hidup usahanya. Banyak pemilik usaha UMKM mengalami kesulitan pembayaran hal tersebut, khususnya pembayaran tagihan kredit, padahal dapat diketahui secara fakta bahwasannya UMKM merupakan sektor penunjang perekonomian terbesar di Indonesia dari krisis moneter yang menimpa Indonesia pada tahun 1998 sampai sekarang, dimana keberadaan UMKM pada saat krisis tersebut terus memberikan dampak pertumbuhan positif kepada Indonesia dalam segi apapun, sehingga sudah seharusnya pemerintah memberikan stimulus untuk menyelamatkan debitur UMKM yang terdampak pandemi covid-19.Kata Kunci: Debitur UMKM; Pandemi Covid-19; Keadaan Memaksa; Restrukturisasi Kredit; Perbankan.
Penguatan Keterwakilan Perempuan Dalam Badan Permusyawaratan Desa
Authors: Kukuh Nur Priambudi
Published: August 2022

AbstractOne of the important institutions in the village is the BPD which is a representative institution at the village level. The element of representation in BPD is women's representation and regional representation. The active involvement of women in organizations in the village such as LKD, PKK, cooperatives, etc. shows that women play a central role in village development. Therefore, women have an urgency to get proportional representation in the Village Representative Body. The Academic Text of the Village Bill states that women's representation in the BPD must contain a 30% quota of representation. However, at the time of promulgation there was no regulation regarding the quota for women's representation in Law Number 6 Year 2014 regarding Villages, but the regulation of women's representation was actually regulated in Domestic Regulation Number 110 Year 2016 regarding the Village Consultative Body but no 30% quota for women was mentioned, but rather the representation of women in BPD is represented by one woman representative. Keywords: Village; Women's Representation; Village Consultative Body.
AbstrakSalah satu lembaga penting di desa adalah BPD yang merupakan lembaga perwakilan di tingkat desa. Unsur keterwakilan dalam BPD adalah keterwakilan perempuan dan keterwakilan wilayah. Keterlibatan aktif perempuan pada organisasi-organisasi di Desa seperti LKD, PKK, koperasi, dan sebagainya menunjukkan bahwa perempuan memegang peran sentral dalam pembangunan di Desa. Oleh karena itu, perempuan memiliki urgensi untuk mendapatkan perwakilan secara proporsional dalam Badan Perwakilan Desa. Naskah Akademik RUU Desa menyebutkan bahwa keterwakilan perempuan dalam BPD harus memuat 30% kuota keterwakilan. Namun pada saat diundangkan tidak terdapat pengaturan mengenai kuota keterwakilan perempuan dalam Undang-Undang Nomor 6 Tahun 2014 tentang Desa, namun pengaturan keterwakilan perempuan justru diatur dalam Peraturan Dalam Negeri Nomor 110 Tahun 2016 tentang Badan Permusyawaratan Desa akan tetapi tidak disebutkan 30% kuota perempuan, melainkan keterwakilan perempuan dalam BPD diwakili oleh satu orang wakil perempuan.Kata Kunci: Desa; Keterwakilan Perempuan; Badan Permusyawaratan Desa.
Penerapan One Clause One Concept Pada Surat Perjanjian Pemborongan (Kontrak) Rumah Tinggal Nomor. 67/SPK/XII/2019 PT. Timur Jaya Pratama
Authors: Nalini Widyantoro
Published: August 2022

AbstractContract is important, because of its content that contains the rights and obligations of each party to achieve an agreed goal at the beginning. The arrangement of contracts in the business dunai is to exchange the interest of the parties so that a fair relationship is established and profitable among others. In praktenya not a little contract content that contains too broad meaning, unclear, overlap tumpag, blurred and so forth. As stated in article 1342 BW which indicates that the contract made should provide certainty. With the contract made by the parties, it can easily control and monitor whether the parties have performed their achievements as promised in the contract. To avoid unwanted things, the contract must contain all the needs of the parties set forth in the clauses of the contract and constantly renew the contents of the contract in order to create a conducive and mutually beneficial business climate. Keywords: Contract; Contract Clause; Conducive Business.
AbstrakKontrak merupakan hal yang penting oleh karena isinya yang mengandung hak dan kewajiban masing-masing pihak untuk mencapai sebuah tujuan yang telah disepakati diawal. Pengaturan kontrak dalam dunai bisnis adalah menjadmian pertukaran kepantingan para pihak sehingga terjalin hubungan yang adil dansaling menguntungkan diantaranya. Dalam praktenya tidak sedikit isi kontrak yang mengandung makna terlalu luas, tidak jelas, tumpag tindih, kabur dan lain sebagainya. Sebagaimana telah disebutkan dalam pasal 1342 BW yang mengisyaratkan bahwa kontrak yang dibuat hendaknya memberi kepastian. Dengan adanya kontrak yang dibuat oleh para pihak maka dapat dengan mudah mengontrol dan memantau apakah para pihak telah melakukan prestasinya sebagaimana telah diperjanjikan dalam kontrak. Untuk menghindari hal yang tidak diinginkan maka kontrak harus memuat seluruh kebutuhan para pihak yang dituangkan dalam klausula kontrak dan senantiasa memperbaharui isi kontrak agar terciptanya iklim bisnis yang kondusif dan saling menguntungkan.Kata Kunci: Kontrak; Klausula Kontrak; Bisnis yang Kondusif.
Sanksi Administrasi Bagi Pelaku Usaha yang Melakukan Kesempatan Perubahan Perilaku Dalam Hukum Acara Persaingan Usaha
Authors: Nirwana Rahma Safura
Published: August 2022

AbstractIssued and ratified Regulation of the Business Competition Supervisory Commission Number 1 of 2019 concerning Procedures for Handling Monopolistic Practices and Unfair Business Competition, which regulates and re-enacts Behavior Change Opportunities for Business Actors suspected of violating Law Number 5 of 1999 concerning Prohibition Monopolistic Practices and Unfair Business Competition. The rearrangement of Behavior Change is considered as a positive thing, but the Commission Regulation has escaped because it does not regulate administrative sanctions for Business Actors who has Changed the Behavior. So whether Business Actors that conduct Changes in Behavior are reduced or permanent or even not subject to administrative sanctions at all, this is not regulated in Commission Regulations. The administrative sanctions are not regulated for Business Actors who conduct Changes in Behavior, this affects the recognition of the Alleged Violation Report for conducting Changes in Business Actors. To answer these problems, the writer uses the statute approach, conceptual approach, and the Case Approach. Keywords: Administrative Sanctions; Business Actors; Behavior Change.
AbstrakDiterbitkan dan disahkannya Peraturan Komisi Pengawas Persaingan Usaha Nomor 1 Tahun 2019 tentang Tata Cara Penanganan Perkara Praktik Monopoli dan Persaingan Usaha Tidak Sehat, yang mengatur dan memberlakukan kembali Kesempatan Perubahan Perilaku bagi Pelaku Usaha yang diduga melakukan pelanggaran terhadap Undang-Undang Nomor 5 Tahun 1999 tentang Larangan Praktek Monopoli dan Persaingan Usaha Tidak Sehat. Diaturnya kembali Perubahan Perilaku dianggap sebagai suatu hal yang positif, namun Peraturan Komisi tersebut telah luput karena tidak mengatur mengenai sanksi administratif bagi Pelaku Usaha yang telah melakukan Perubahan Perilaku. Sehingga apakah Pelaku Usaha yang melakukan Perubahan Perilaku dikurangi atau tetap atau bahkan tidak dikenakan sanksi administrasi sama sekali, hal tersebut tidak diatur di dalam Peraturan Komisi. Tidak diaturnya sanksi administrasi bagi Pelaku Usaha yang melakukan Perubahan Perilaku, hal tersebut mempengaruhi pengakuan Laporan Dugaan Pelanggaran untuk melakukan Perubahan Perilaku Pelaku Usaha. Untuk menjawab permasalahan tersebut, penulis menggunakan Pendekatan Undang-Undang (statute approach), Pendekatan Konseptual (conceptual approach), dan Pendekatan Kasus (Case Aprroach).Kata Kunci: Sanksi Administrasi; Pelaku Usaha; Perubahan Perilaku.
Tindak Penghasutan Dalam Pasal 160 KUHP Pasca Putusan Mahkamah Konstitusi Nomor 7/PUU-VII/2009
Authors: Toufan Hazmi Haidi
Published: August 2022

AbstractIncitement is an act that has been regulated in the Criminal Code which is itself an adaptation of Wetboek Van Strafrecht Nederland so that there are still colonial articles, one of which is Article 160 which regulates sedition. The Constitutional Court has conducted an examination of Article 160 of the Indonesian Criminal Code in its decision to formulate the original formal offense into a material formulation. This research aims to explain the Qualifications of incitement criminal offenses based on statutory regulations and the basic considerations of the Constitutional Court which formulates the incitement criminal offenses as material offenses. The results of this study indicate that inciting is different from persuasion, where persuading there are endeavors that must be fulfilled such as by giving gifts, promises, abusing power, abusing position, using the threat of convenience and deception, whereas instigation has a clear and devoid of endeavors namely to committing criminal acts, committing violence against public authorities or not complying with both the provisions of the law and the position orders given based on the law. Keywords: Incitement; Material Offense.
AbstrakPenghasutan merupakan suatu perbuatan yang telah diatur dalam KUHP yang mana KUHP sendiri merupakan saduran dari Wetboek Van Strafrecht Nederland sehingga masih terdapat pasal bersifat kolonial dimana salah satunya adalah Pasal 160 yang mengatur penghasutan. Mahkamah Konstitusi telah melakukan pengujian terhadap Pasal 160 KUHP dalam putusannya perumusan yang semula delik formil menjadi perumusan materiil. Penelitian ini bertujuan untuk menjelaskan Kualifikasi tindak pidana penghasutan berdasarkan peraturan perundang-undangan dan Dasar pertimbangan Mahkamah Konstitusi yang merumuskan tindak pidana penghasutan sebagai delik materiil. Hasil dari penelitian ini menunjukan bahwa menghasut berbeda dengan membujuk, dimana membujuk ada ikhthiar yang harus dipenuhi seperti dengan memberikan pemberian, janji-janji, menyalahgunakan kekuasaan, menyalahgunakan kedudukan, menggunakan kerasan ancaman dan muslihat, sedangkan menghasut memiliki tujuan yang jelas dan tanpa ikhtiar yaitu untuk melakukan perbuatan pidana, melakukan kekerasan terhadap penguasa umum atau tidak menuruti baik ketentuan undang-undang maupun perintah jabatan yang diberikan berdasar undang-undang.Kata Kunci: Penghasutan; Delik Materiil.
Aturan Kampanye Bagi Aparatur Sipil Negara Sebagai Wujud Asas Netralitas
Authors: Ulfa Septian Dika
Published: August 2022

AbstractState Civil Apparatus is a profession for Civil Servants and Government Employees with Work Agreements that work in government institutes. State Civil Apparatus is the servant of the state and a public servant who is required to uphold the ideology of Pancasila, the faithful and defend the Constitution of the Republic of Indonesia in 1945 and the legitimate government, as well as to serve the country and people of Indonesia. The smoothness in the implementation of the task of the government and national development is very dependent on the State Civil Apparatus. So, no wonder if the State Civil Apparatus are required to maintain professionalism and its neutrality, especially when General Elections and Local Elections are taking place. Because not infrequently the State Civil Apparatus who commits a breach of neutrality by participating in campaign activities ahead of the General Election and Local Elections. This Legal research is using 3 (three) approach, namely, the Statute Approach, the Historical Approach, and the Conceptual Approach which in this case is made to answer ratio legis of the prohibition of the participation of the State Civil Apparatus in campaign activities. Keywords: State Civil Apparatus; Prefessional; Neutrality; Campaign; General Elections; Local Elections.
AbstrakAparatur Sipil Negara (ASN) adalah profesi bagi Pegawai Negeri Sipil dan Pegawai Pemerintah dengan Perjanjian Kerja yang bekerja pada instansi pemerintah. ASN merupakan abdi negara dan abdi masyarakat yang dituntut untuk memegang teguh ideologi Pancasila, setia dan mempertahankan UUD NRI Tahun 1945 dan pemerintahan yang sah, serta mengabdi kepada negara dan rakyat Indonesia. Kelancaran dalam penyelenggaraan tugas pemerintah dan pembangunan nasional sangat bergantung pada ASN. Sehingga tidak heran apabila ASN dituntut untuk menjaga profesionalitas dan netralitasnya, terutama saat Pemilihan Umum dan Pemilihan Kepala Daerah sedang berlangsung. Karena tak jarang ASN yang melakukan pelanggaran netralitas dengan ikut serta dalam kegiatan kampanye menjelang Pemilihan Umum dan Pemilihan Kepala Daerah. Penelitian hukum ini menggunakan 3 (tiga) pendekatan yaitu, Pendekatan Peraturan Perundang-undangan, Pendekatan Historis, dan Pendekatan Konseptual yang dalam hal ini dilakukan untuk menjawab ratio legis pelarangan kampanye bagi ASN.Kata Kunci: Aparatur Sipil Negara; Profesionalitas; Netralitas; Kampanye; Pemilihan Umum; Pemilihan Kepala Daerah.
Rendimento do filé de tucunaré (Cichla cf. monoculus) Osteichthyes, Cichlidae em diferentes cortes da cabeça
Authors: Cosme Shirley  Silva , Sanches Alex Guimarães , Silva Maryelle Barros da , Moreira Elaine Gleice Silva , Cordeiro Carlos Alberto Martins
Published: August 2022

O tucunaré (Cichla cf. monoculus), é um peixe muito apreciado para o consumo, porém são poucos os estudos relacionados ao seu processamento e rendimento. Deste modo, objetivou-se neste trabalho avaliar o efeito do corte da cabeça sobre os parâmetros morfométricos relacionados ao rendimento do filé. Para isso, 60 exemplares de tucunaré foram dividos e submetidos ao corte oblíquo e reto da cabeça. As carcaterísticas morfométricas e a composição centesimal foram investigados. O corte oblíquo da cabeça resultou em maior peso e rendimento do tronco limpo e do filé com e sem pele em relação ao corte reto. Quanto aos resíduos, o rendimento da cabeça foi mais associado ao corte reto, enquanto o peso e o rendimento da pele com o corte oblíquo. Com relação as análises morfométricas, a altura do peixe influencia positivamente no rendimento do filé, enquanto a composição centesimal é afetada pela condição de cultivo. Nas condições deste estudo e visando o melhor aproveitamento e rendimento do filé do tucunaré, recomenda-se o corte oblíquo da cabeça.
ÍNDICE DE CLOROFILA E PRODUTIVIDADE DE CULTIVARES DE TOMATE CEREJA (Lycopersicon esculentum var. cerasiforme), PRODUZIDOS EM ALTAS TEMPERATURAS, SOB AMBIENTE PROTEGIDO
Authors: Santos Soares Denilze , Souza Carvalho Felipe , Vitória dos Santos Thaís , Santos Santos Taylane , Amaro de Carvalho Tayna , Da Silva Borges Luciana
Published: August 2022

Dentre as hortaliças produzidas no Brasil, a tomaticultura é um dos cultivos considerado de maior importância. A escassez de cultivares com genótipos adaptados as condições de elevada temperatura e alta precipitação, tem sido o motivo de baixos valores de produtividade da Região Norte. Objetivou-se com este trabalho avaliar o índice de clorofila e produtividade de cultivares de tomate cereja e suas respostas as condições de altas temperaturas, sob ambiente protegido. O experimento foi implantado e executado na Universidade Federal Rural da Amazônia – Campus Paragominas. Utilizou se o delineamento experimental em blocos casualisados com três cultivares de tomate, yashi, yubi e carolina, com seis repetições, no qual 6 plantas foram avaliadas. Os dados obtidos foram submetidos á análise de variância, e as médias comparadas pelo teste de Tukey a 5% de probabilidade. Foram avaliadas as características área foliar, largura foliar, comprimento foliar, fator de proporção, IAF, altura de planta, °brix, diâmetro, número e peso dos frutos, produtividade, e índices de clorofila a, b e total. As cultivares Carolina, Yubi e Yashi não apresentaram diferenças no índice de clorofila. Com relação a produtividade as cultivares Yashi e Yubi apresentaram os melhores resultados, cultivadas em ambiente protegido com telado e em altas temperaturas.
PERFIL EPIDEMIOLÓGICO DA GRAVIDEZ NA ADOLESCÊNCIA NAS MICRORREGIÕES DO ESTADO DO TOCANTINS DURANTE OS ANOS DE 2008 - 2018
Authors: Silingowschi de Oliveira Esther , Jardim Gomes Camila , Pereira Parreira Artur , De Jesus Pinheiro Maria Lara , Ramos Oliveira Kaio , Cândida de Queiroz Santos Anjos Fabiana , Ferreira Barbosa Priscila
Published: August 2022

O Tocantins apresenta população total de aproximadamente 1.383.445 habitantes sendo cerca de 10% são adolescentes do sexo feminino, nesse sentido, uma atenção deve ser voltada a essa classe já que nos últimos anos tem se observado os crescimentos na quantidade de meninas que se tornam mães durante essa fase. O objetivo do trabalho foi expor os números e sugerir quais fatores podem estar relacionados com a gravidez na adolescência. Os dados foram retirados do SINASC, no período de 2008 a 2018. Foi encontrado que dos 272983 nascidos vivos, 64.623 eram filhos   de   mães   adolescentes. Foi exposto que uma defasagem na formação educacional pode estar relacionada com esse índice elevado, evidenciou-se também um maior número de partos vaginais bem como reduzidas consultas pré-natais nas microrregiões com serviço público de saúde deficitário, com destaque para o Jalapão. É recomendado um investimento na atenção básica, principalmente nas microrregiões mais afetadas e na oferta não apenas de recursos, mas de atenção especial e estruturada, proporcionando melhor acesso à informação e instrução das adolescentes.
RESÍDUO DE FLUOROQUINOLONA EM CARNE DE FRANGO E EFEITO DA MISTURA DE FEZES NA RESISTÊNCIA DE Salmonella Heidelberg À ENROFLOXACINA
Authors: Zonatto Fernanda , Oliveira Debora Francielly , Costa dos Santos Eder , Hashimoto Elisabete Hiromi
Published: August 2022

O objetivo deste trabalho foi validar uma metodologia para detecção de enrofloxacina em tecidos de frango e pesquisar a influência da mistura de fezes de frango na resistência de Salmonella spp. à enrofloxacina. Enrofloxacina (10 mg.kg-1) foi administrado oralmente e os tecidos (músculo, fígado e rim) coletados até o 10º dia da última dose e analisados por LCMS. Um total de 124 amostras de fezes foram coletadas da cama de aviários foram submetidas ao isolamento de Salmonella spp. e paralelamente, a mistura fecal foi adicionada de solução contendo enrofloxacina (10 μg.mL-1) e Salmonella spp. isolada e identificada. O limite de quantificação e detecção de LCMS foram 20 e 10 μg.kg-1, respectivamente e o tempo de depleção nos tecidos foi de 3 dias. Quando exposta à enrofloxacina na presença de mistura fecal, Salmonella Heidelberg mostrou menor susceptibilidade (39,8%) à enrofloxacina do que quanto exposta isoladamente (100%). Considerando todos os parâmetros de validação analisados, LCMS foi sensível e aplicável à análise de rotina de resíduos de fluoroquinolonas. Diferenças de susceptibilidade à enrofloxacina na presença de material fecal indicam a necessidade de considerar as condições ambientais na resistência de patógenos, principalmente à classes de antimicrobianos de uso na medicina veterinária e humana.
VALIDAÇÃO DE LIMPEZA NA INDÚSTRIA FARMACÊUTICA: REVISÃO
Authors: De Almeida Ribeiro Oliveira Gerlon
Published: August 2022

Na história da indústria farmacêutica inúmeros desvios que afetaram a qualidade dos medicamentos deram-se devido às contaminações cruzadas. A fim de evitar as contaminações, as Boas Práticas de Fabricação, descritas na RDC 301/2019, exigem documentação de todos os processos de produção de medicamentos, com a definição prévia dos procedimentos. A validação de limpeza pode ser definida como uma evidência documentada que garante a eficácia do procedimento de limpeza realizado nos equipamentos, demonstrando que o produto fabricado após o processo de limpeza não está contaminado por resíduos. O objetivo deste trabalho foi descrever, por meio de uma revisão bibliográfica, a importância da validação de limpeza de equipamentos e a forma como isso é feito em equipamentos da indústria farmacêutica. Para tanto, foi realizada pesquisa bibliográfica nas bases de dados Periódicos Capes, Scielo e Google Acadêmico, usando os seguintes termos de busca: “validação de limpeza”, “processo de limpeza”, “qualidade na indústria farmacêutica”, “validação”, “qualidade de medicamentos” e “contaminação cruzada”, e suas correspondentes em inglês. As análises realizadas após um procedimento de limpeza bem executado, devem apresentar resultados dentro dos limites aceitáveis, para se garantir que a limpeza é suficiente e que, portanto, o medicamento seja produzido com segurança e qualidade.
COMPARAÇÃO FARMACOECONÔMICA ENTRE MEDICAMENTOS E FITOTERÁPICOS UTILIZADOS NO TRATAMENTO DA DEPRESSÃO
Authors: Da Silva Marinho Larissa Caroline , Lameira da Silva Rhaissa Calazans , Nobre Lima do Nascimento Guilherme
Published: August 2022

A depressão é um transtorno mental caracterizado por tristeza, perda de interesse e baixa autoestima, entre outros. Dentre os tratamentos de escolha, têm-se as psicoterapias, os antidepressivos (medicamentos sintéticos) e as plantas medicinais - fitoterapia. Estima-se que a depressão e a ansiedade sejam responsáveis por uma perda anual de produtividade de mais de um trilhão de dólares. Ao  se tratar de estudos de custo-efetividade para determinar qual seria a melhor medicação de referência de tratamento para a depressão, observa-se estudos escassos ou inexistentes na maioria dos países. Deste modo, o presente estudo busca comparar os medicamentos antidepressivos com os fitoterápicos usados no tratamento da depressão com relação ao custo-benefício dos mesmos, expondo também a acareação dos efeitos colaterais de cada um, nos municípios de Palmas, Araguaína e Gurupi do Estado do Tocantins. A análise de  custo-benefício foi avaliada considerando o custo médio da medicação por dia de tratamento e menor quantidade de efeitos colaterais, e foi realizada a comparação de preços entre a aquisição de medicamentos em drogarias ou em farmácias e comparação de preços entre as cidades do estudo.
REPRESENTAÇÕES SOCIAIS SOBRE A FORMAÇÃO EM EDUCAÇÃO AMBIENTAL NO CURSO DE LICENCIATURA EM CIÊNCIAS BIOLÓGICAS
Authors: Angelo José Adriano Cavalcante
Published: August 2022

A Educação Ambiental desponta no cenário mundial como uma ação educativa em resposta à crise ambiental instalada, causada pela ação humana. A proposta deste trabalho foi analisar as representações sociais de discentes do curso de Licenciatura em Ciências Biológicas acerca de sua formação em Educação Ambiental. Para tal, foi utilizada a Teoria das Representações Sociais (MOSCOVICI, 1978, 2011; JODELET, 1989, 1995, 2001), um conhecimento socialmente formado, baseado na construção de uma realidade pertinente a um grupo específico. Como metodologia de pesquisa, os dados foram coletados com a técnica de grupo focal e analisados com a Análise de Conteúdo proposta por Bardin (2016). Como produtos, emergiram três categorias principais, que tratam dos (a) atributos da Educação Ambiental, da (b) qualidade da formação e, da (c) estrutura da formação. Diante disso, os resultados apontam para a ressignificação da formação docente em Educação de forma a contemplar as novas demandas para uma sociedade mais sustentável.
Islam in Human Resources Management and Organizational Behavior Discourses
Authors: Linando Jaya Addin
Published: August 2022

The importance of religion in management studies is rising and is better appreciated nowadays. As one of the major acknowledged and one of the most misunderstood religions globally, Islam and all things related to Muslims in the workplace should also gain more attention from the management scholars to promote better understanding and mutual respect. This paper tries to answer the broad question of ‘what are the main themes of Islam in Human Resources Management (HRM) and Organizational Behavior (OB) discourses?’. The paper identifies three focal themes within the topic: current workplace circumstances for Muslims; Islamic religiosity from HRM and OB perspectives; and Islamic viewpoint of work. Through the narrative review approach, this paper establishes three contributions. The first contribution is to discuss the essential issues of Islam and Muslims in HRM and OB discourses. Second, this paper bridges the contemporary HRM-OB discourses and Islamic teachings. Third, this paper suggests possible discussion points for further advancement of Muslims in the workplace topic.
Ethical decision intention of first-line managers: Case study in Malaysia hotel industry
Authors: Chelliah Thamil-Durai , Chan Ling-Meng
Published: August 2022

In this study, the researchers try to identify the factors that encourage/prohibit them to reason and behave ethically in order to derive a prescriptive guidance that can enhance the process, while practicing managers to develop policies and programs that strengthened employees’ ethical resolve on the job. In this study, Bratman’ Belief-Desire-Intention (BDI) model used to explain the research framework, the ethical decision intention component (ethical awareness, ethical judgment and ethical intention) are examined how their relationship towards each other. The researchers has employed survey-based approach to meet the study’s objectives and self-administrated questionnaires were used to gather data from 120 first line managers who work in 4-star and 5-star hotels in Malaysia respectively. These significance findings make a unique contribution towards the development of moral theories, as the researchers will not perceive them as individual but a comprehensive process to aware, evaluate and intend to act morally right. Through the findings of this study, it urges organizations to emphasize the importance of the ethical dilemma in their professional education at both the initial stage and through ongoing professional development.
Pelatihan Desain dan Pemodelan Bangunan Menggunakan Program SAP 2000 di Jurusan Desain Pemodelan Informasi Bangunan (DPIB) SMK PGRI 1 Gresik
Authors: Irsyadi Rezky Setya , Hidayat Hidayat
Published: August 2022

Dalam upaya menjaga mutu pendidikan terhadap pengaruh perkembangan teknologi informasi yang terdapat pada kurikulum SMK jurusan Desain Pemodelan Informasi Bangunan (DPIB) mata pelajaran struktur bangunan, maka perlu dikenalkan kepada peserta didik bahwasanya terdapat program komputer yang dapat menunjang mata pelajaran tersebut. Program komputer tersebut adalah SAP 2000 yang dapat digunakan untuk menganalisis gaya – gaya yang bekerja pada struktur balok, kolom, pelat, dan penampang konstruksi rumah 2 lantai. Sebagai bentuk upaya yang dapat dilakukan untuk menjaga mutu pendidikan terhadap pengaruh perkembangan teknologi informasi yang terdapat pada kurikulum SMK jurusan Desain Pemodelan Informasi Bangunan (DPIB)  mata pelajaran struktur bangunan, maka perlu dilakukan sebuah usulan untuk mengadakan kegiatan ” Pelatihan Desain dan Pemodelan Bangunan Rumah 2 Lantai Mengguanakan Program SAP 2000 Di Jurusan Desain dan Pemodelan Infomasi Bangunan (DPIB) SMK PGRI 1 Gresik”. Di akhir kegiatan, peserta diminta untuk menilai atau mengisi pertanyaan yang berkaitan dengan 8 komponen penilaian yang sudah disebutkan pada bab pembahasan. Secara keseluruhan hasil yang didapat adalah para peserta memilih atau menilai pada angka 3, 4, dan 5. Yang artinya bahwa kegiatan ini masih bisa diterima layak berdasarkan 8 komponen penilaian tersebut dan tujuan pembelajaran pada pelatihan ini di nilai tercapai
Model Inkubator Bisnis Teknologi pada Program Pengembangan Kewirausahaan Mahasiswa UNIKOM Berbasis Metode Sector Specific Incubator
Authors: Kurniawan Bobi , Herdiana Budi , Alviana Sopian
Published: August 2022

Ketertarikan berwirausaha dikalangan mahasiswa saat ini cukup besar sehingga memberikan dampak perubahan positif terhadap perekonomian lokal maupun nasional. Menghadapi perubahan ini diperlukan sebuah dasar gagasan bisnis yang harus dibangun sehingga akan melahirkan wirausaha-wirausaha muda yang Tangguh dan berdaya saing kuat. Masalah menjaga konsistensi dan strategi bisnis inilah yang menjadi penghambat utama sehingga berpengaruh pada berkembangnya usaha bisnis yang telah dirintis. Karena itu usulan model inkubasi bisnis teknologi dengan pendekatan pelatihan dan pendampingan bagi calon wirausaha muda dilakukan untuk menyelesaikan masalah ini. Sedangkan sector specific incubator digunakan sebagai metode teknik pelatihan dan pendampingan dengan memaksimalkan potensi sumber daya seperti mahasiswa, fasilitas fisik dan platform teknologi. Adapun tujuan yang akan dicapai adalah ingin memberikan penguatan gagasan dan semangat berwirausaha bagi mahasiswa guna menghadapi era bisnis digital. Jumlah peserta yang mengikuti seleksi inkubasi sebanyak 77 orang terdiri dari mahasiswa dan alumni. Seleksi akhir didapatkan 6 mahasiswa sebagai calon wirausaha muda yang nantinya mampu mengimplementasikan gagasan bisnisnya berdasarkan proses inkubasi ini. Mereka diharapakan berhasil menerapkan gagasan strategi bisnisnya berdasarkan indikator banyaknya produk-produk yang terjual pasca inkubasi. Sedangkan secara kuantitas keberhasilannya tersebut bisa dilihat dari jumlah omzet produk yang terjual dengan rata-rata diatas 50 % dengan capaian nilai akhir usaha bisnis lebih dari 70 %.
Pengenalan E-Commerce Pada Pokdarwis Desa Cikakak Dalam Hal Upaya Pengembangan UMKM
Authors: Fathoni M Yoka , Darmansah Darmansah , Wijayanto Sena , Aldo Dasril
Published: August 2022

Pada era saat pandemic E-Commerce merupakan alternative pilihan masyarakat untuk berbelanja secara online. Dampak positif dengan adanya internet sebagai media penjualan sistem pemasaran menjadi lebih luas, simple dan terperinci, dengan ini masyarakat dapat mengenal E-Commerce sebagai media penjualan online. Tujuan dari pengelanan E-Commerce adalah untuk menambah wawasan masyarakat desa Cikakak dari fungsi media promosi dan penjualan elektronik untuk mengetahui kendala yang dihadapi dalam memperkenalkan media website e-commerce. Jenis pengabdian masyarakat ini dilakukan secara langsung ke Desa Cikakak. Pengabdian ini mengambil studi kasus pada Pokdarwis desa Cikakak dengan sumber data yang diperoleh yaitu melalui sumber data primer dan sumber data sekunder. Hasil pengabdian berupa pembuatan toko online di E-Commerce dengan menggunakan media promosi market place seperti Tokopedia, Bukalapak dan Google My Business sehingga dapat membantu serta mempermudah mengurangi biaya yang dikeluarkan, dapat menyampaikan informasi secara detail dan cepat mengenai produk kepada pelanggan. Berdasarkan hasil pengabdian masyarakat ini diharapkan dapat membantu Desa Cikakak untuk mendapatkan hasil yang lebih maksimal serta dapat bersaing dengan toko offline maupun online yang sejenis.
Towards Sustainable Aluminium Processing: Autonomous Quality Control Using Business Analytics
Authors: Matlala Kgothatso , Mishra Amit Kumar , Puthal Deepak
Published: August 2022

This paper presents work done as part of a transformation effort towards a greener and more sustainable Aluminium manufacturing plant. The effort includes reducing the carbon footprint by minimising waste and increasing operational efficiency. The contribution of this work includes the reduction of waste through the implementation of autonomous, real-time quality measurement and classification at an Aluminium casthouse. Data is collected from the MV20/20 which uses ultrasound pulses to detect molten Aluminium inclusions, which degrade the quality of the metal and cause subsequent metal waste. The sensor measures cleanliness, inclusion counts and distributions from 20 - 160 microns. The contribution of this work is in the development of business analytics to implement condition-based monitoring through anomaly detection, and to classify inclusion types for samples that failed. For anomaly detection, multivariate K-Means and DBSCAN algorithms are compared as they have been proven to work in a wide range of datasets. For classification, a two-stage classifier is implemented. The first stage classifies the success or failure of the sample, while the second stage classifies the inclusion responsible for the failed sample. The algorithms considered include logistic regression, support vector machine, multi-layer perceptron and radial basis function network. The multi-layer perceptron offers the best performance using k-fold cross-validation, and is further tuned using grid search to explore the possibility of an even better performance. The results reveal that the model has achieved a global maximum in performance. Recommendations include the integration of additional sensor systems and the improvements in quality assurance practices.
Loss Of Protein Stability And Function Caused By POR-Rs17853284 Linked To Lower Testosterone Levels
Authors: Rojas Velazquez Maria Natalia , Noebauer Mathias , Pandey Amit V
Published: August 2022

Cytochrome P450 oxidoreductase (POR) is the redox partner of steroid and drug-metabolizing cytochromes P450 located in the endoplasmic reticulum. Mutations in POR cause a broad range of metabolic disorders. The POR variant rs17853284 (P228L) identified by genome sequencing has been linked to lower testosterone levels and reduced P450 activities. We expressed POR wild type and the P228L variant in bacteria, purified the proteins, and performed protein stability and catalytic functional studies. Variant P228L affected the stability of the protein as evidenced by lower unfolding temperatures and higher sensitivity to urea denaturation. A significant reduction of small molecule metabolism was observed with POR P228L while activities of CYP3A4 were reduced by 25%, and activities of CYP3A5, and CYP2C9 were reduced by more than 40% compared to WT POR. The 17,20 lyase activity of CYP17A1 responsible for production of main androgen precursor dehydroepiandrosterone, was reduced to 27% of WT in presence of P228L variant of POR. Based on in silico and in vitro studies we predict that the change of proline to leucine may change the rigidity of the protein, causing conformational changes in POR, leading to altered electron transfer to redox partners. A single amino acid change can affect protein stability and cause a severe reduction in POR activity. Molecular characterization of individual POR mutations is crucial for a better understanding of the impact on different redox partners of POR.
Synthetic Aperture Radar Doppler Tomography Reveals Details of Undiscovered High-Resolution Internal Structure of the Great Pyramid of Giza
Authors: Biondi Filippo , Malanga Corrado
Published: August 2022

A problem with synthetic aperture radar (SAR) is that, due to the poor penetrating action of electromagnetic waves inside solid bodies, the capability to observe inside distributed targets is precluded. Under these conditions, imaging action is provided only on the surface of distributed targets. The present work describes an imaging method based on the analysis of micro-movements on the Khnum-Khufu Pyramid, which are usually generated by background seismic waves. The results obtained prove to be very promising, as high-resolution full 3D tomographic imaging of the pyramid's interior and subsurface was achieved. Khnum-Khufu becomes transparent like a crystal when observed in the micro-movement domain. Based on this novelty, we have completely reconstructed internal objects, observing and measuring structures that have never been discovered before. The experimental results are estimated by processing series of SAR images from the second-generation Italian COSMO-SkyMed satellite system, demonstrating the effectiveness of the proposed method.
Modeling DTA by Combining Multiple-Instance Learning with a Private-Public Mechanism
Authors: Wang Chunyu , Chen Yuanlong , Zhao Lingling , Wang Junjie , Wen Naifeng
Published: August 2022

The prediction of drug-target interactions plays a fundamental role in facilitating drug discovery, where the goal is to find prospective drug candidates. With the increase in the number of drug-protein interactions, machine learning techniques, especially deep learning methods, have become applicable for drug-target interaction discovery because they significantly reduce the required experimental workload. In this paper, we present a spontaneous formulation of the drug-target interaction prediction problem as an instance of multi-instance learning. We address the problem in three stages, first organizing given drug and target sequences into instances via a private-public mechanism, then identifying the predicted scores of all instances in the same bag, and finally combining all the predicted scores as the output prediction. A comprehensive evaluation demonstrates that the proposed method outperforms other state-of-the-art methods on three benchmark datasets.
COVID-19 Knowledge, Attitudes and Practices and Vaccine Acceptability in Rural Western Kenya and an Urban Informal Settlement in Nairobi, Kenya, May 2021: A Cross-sectional Survey
Authors: Wanyonyi Carolyne Nasimiyu , Audi Allan , Oduor Clifford , Ombok Cynthia , Oketch Dismas , Aol George , Ouma Alice , Osoro Eric M. , Ngere Isaac , Njoroge Ruth , Munyua Peninah M. , Lo Terrence , Herman-Roloff Amy , Bigogo Godfrey , Munywoki Patrick K.
Published: August 2022

An important step towards COVID-19 pandemic control is adequate knowledge and adherence to mitigation measures, including vaccination. We assessed the level of COVID-19 knowledge, attitudes, and practices among residents from an urban informal settlement in the City of Nairobi (Kibera), and a rural community in western Kenya (Asembo). A cross-sectional survey was implemented from April to May 2021 among randomly selected adult residents from a population-based infectious diseases surveillance (PBIDS) cohort in Nairobi and Siaya Counties. Factors associated with the level of COVID-19 KAP, were assessed using multivariable regression methods. COVID-19 vaccine acceptance was 83.6% for the participants from Asembo and 59.8% in Kibera. The reasons cited for vaccine hesitancy in Kibera were safety concerns (34.0%), insufficient information available to decide (18.0%), and a lack of belief in the vaccine (21.0%), while the reasons in Asembo were safety concerns (55.0%), insufficient information to decide (26.0%) and lack of belief in the vaccine (11%). Our study findings suggest the need for continued public education to enhance COVID-19 knowledge, attitudes, and practices to ensure adherence to mitigation measures. Urban informal settlements require targeted messaging to improve vaccine awareness, acceptability, and uptake.
Newcastle Disease Genotype VII Outbreaks in Poultry across Egypt are associated with Enzootic Prevalence of the Virus in Wild Birds
Authors: Eid Amal A.M. , Hussein Ashraf , Hassanin Ola , Elbakrey Reham M. , Daines Rebecca , Sadeyen Jean-Remy , Abdien Hanan M.F , Chrzastek Klaudia , Iqbal Munir
Published: August 2022

Newcastle disease virus (NDV) genotype VII is a highly pathogenic Orthoavulavirus that has caused multiple outbreaks among poultry in Egypt since 2011. This study aimed to investigate the genetic diversity of NDV prevailing in domestic and wild birds in Egyptian governorates. A total of 37 oropharyngeal swabs from wild birds and 101 swabs from domestic bird flocks including chickens, ducks, turkeys, and swans were collected from different geographic regions within 13 governorates during 2019-2020. Virus isolation and propagation via embryonated eggs revealed 91 swab samples produced allantoic fluid containing hemagglutination activity, suggestive of virus presence. The use of RT-PCR targeted to F gene successfully detected NDV in 85 samples. The geographical prevalence of NDV spread to 12 governorates in domestic birds, migratory and non-migratory wild birds. Following whole genome sequencing, we assembled six NDV genome sequences (70 - 99% of genome coverage), including five full F gene sequences. All NDV strains carried high virulence, based on the presence of polybasic amino acids (RRQRF) at the F gene cleavage site. Phylogenetic analysis revealed that the NDV strains belonged to class II within genotype VII.1.1. The presence of genetically similar virulent NDV in wild birds further highlights their role in the dissemination of NDV in poultry populations across Egypt. Continued genomic surveillance in both wild birds and poultry would be necessary for monitoring NDV incursions and genetic diversification.
Altered microRNA Transcriptome in Cultured Human Airway Cells upon Infection with SARS-CoV-2
Authors: Diallo Idrissa , Jacob Rajesh Abraham , Vion Elodie , Kozak Robert A. , Mossman Karen , Provost Patrick
Published: August 2022

Numerous proteomic and transcriptomic studies have been carried out to better understand the current multi-variant SARS-CoV-2 virus mechanisms of action and effects. However, they are mostly centered on mRNAs and proteins. The effect of the virus on human post-transcriptional regulatory agents such as microRNAs (miRNAs) involved in the regulation of 60% of human gene activity remains poorly explored. Similar to what we have previously done with other viruses such as Ebola and HIV, in this study we investigated the miRNA profile of lung epithelial cells following infection with SARS-CoV-2. At the 24 and 72 hours post-infection, SARS-CoV-2 did not drastically alter the miRNome. About 90% of the miRNAs remained non-differentially expressed. The results revealed that miR-1246, miR-1290 and miR-4728-5p were the most upregulated over time. miR-196b-5p and miR-196a-5p were the most downregulated at 24 h while at 72 h, miR-3924, miR-30e-5p and miR-145-3p showed the highest level of downregulation. In the top significantly enriched KEGG pathways of genes targeted by differentially expressed miRNAs we found, among others, MAPK, RAS, P13K-Akt and renin secretion signaling pathways. By RT-qPCR, we also showed that SARS-CoV-2 may regulate several predicted host mRNA targets involved in the entry of the virus into host cells (ACE2, TMPRSS2, ADAM17 and FURIN), in renin–angiotensin system (RAS) (Renin, Angiotensinogen, ACE), innate immune response (IL-6, IFN1β, CXCL10, SOCS4) and fundamental cellular processes (AKT, NOTCH, WNT). Finally, we demonstrated by dual luciferase assay a direct interaction between miR-1246 and ACE-2 mRNA. This study highlights the modulatory role of miRNAs in the pathogenesis of SARS-CoV-2.
An Integrative Analysis Identified Schizophrenia-Associated Brain Cell Types and Gene Expression Changes
Authors: Cai Wenxiang , Song Weichen , Liu Zhe , Maharjan Dhruba Tara , Liang Jisheng , Lin Guan Ning
Published: August 2022

Schizophrenia (SCZ) is a severe mental disorder that may result in hallucinations, delusions, and extremely disordered thinking. How each cell type in the brain contributes to SCZ occurrence is still unclear. Here, we leveraged the human dorsolateral prefrontal cortex bulk RNA-seq data, then used the RNA-seq deconvolution algorithm CIBERSORTx to generate SCZ brain single-cell RNA-seq data for a comprehensive analysis to understand SCZ-associated brain cell types and gene expression changes. Firstly, we observed that the proportions of brain cell types in SCZ differed from normal samples. Among these cell types, astrocyte, pericyte, and PAX6 cells were found to have a higher proportion in SCZ patients (astrocyte: SCZ = 0.163, Control = 0.145, P.adj = 4.9×10-4; pericyte: SCZ = 0.057, Control = 0.066, P.adj = 1.1×10-4; PAX6 : SCZ = 0.014, Control = 0.011, P.adj = 0.014), while the L5/6_IT_CAR3 cells and LAMP5 cells are the exact opposite (L5/6_IT_Car3 : SCZ = 0.102, Control = 0.108, P.adj = 0.016; LAMP5 : SCZ = 0.057, Control = 0.066, P.adj = 2.2×10-6). Next, we investigated gene expression in cell types and functional pathways in SCZ. We observed chemical synaptic transmission dysregulation in two types of GABAergic neurons (PVALB and LAMP5), and immune reaction involvement in GABAergic neurons (SST) and non-neuronal cell types (endothelial and oligodendrocyte). Furthermore, we observed that some differential expression genes from bulk RNA-seq displayed cell-type-specific abnormal in the expression of molecules in SCZ. Finally, the cell types with the SCZ-related transcriptomic changes could be considered to belong to the same module since we observed two major similar coordinated transcriptomic changes across these cell types. Together, our results offer novel insights into cellular heterogeneity and the molecular mechanisms underlying SCZ.
A Novel Mitophagy Enhancer Protects Cardiomyocytes against Hypoxia/Reoxygenation
Authors: Yan Xin , Gao Xiang , Hou Shanshan , Jockusch Steffen , Gibson K Michael , Bi Lanrong
Published: August 2022

Ischemia/reperfusion (I/R) injury results in cell death by inducing apoptosis. During I/R, early generation of mitochondrial reactive oxygen species (mtROS) can induce neighboring mitochondria to release additional ROS, a toxic cycle resulting in significant mitochondrial and cellular injury. Oxidative damage in the mitochondria contributes to various pathologies, including I/R injury. Accordingly, preventing mitochondrial oxidative damage should be therapeutically relevant for many disorders, including cardiovascular diseases. We recently discovered an Indole-Peptide-Tempo Conjugate (IPTC) that served as a novel bifunctional agent with both antioxidant and autophagy-modulating capacity. Here, we demonstrate that IPTC can protect H9C2 cardiomyocytes from hypoxia/reoxygenation (H/R) injury that results from mtROS overproduction due to impaired mitophagy and resultant mitochondrial dysfunction. We hypothesize that the mechanism of action of IPTC involves the capacity to decrease mtROS combined with induction of mitophagy.