bluuebunny/crossref_metadata_2025 huggingface dataset:
Ogt Demonstrated Conspicuous Clinical Significance in Cancers, from Pan-Cancer to Small-Cell Lung Cancer
Authors: Tang Deng , Li Guo-Sheng , Xu Ruo-Xiang , Zhu Si-Yi , Luo Jing , Zheng Jin-Hua , Liu Jun , Lu Hua-Song , Jin Mei-Hua , Bao Chong-Xi , Tian Jia , Deng Wu-Sheng , Zeng Neng-Yong , Zhou Hua-Fu , Kong Jin-Liang , Chen Gang
Published: March 2022

The clinical progression of small-cell lung cancer (SCLC) remains pessimistic. The aim of the present study was to promote the understanding of the clinical significance and mechanism of O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) in SCLC. Wilcoxon tests, standardized mean difference (SMD), and Kruskal–Wallis tests were utilized to compare OGT level differences among the experimental and control groups. The univariate Cox regression analysis, Kaplan–Meier curves, and receiver operating characteristic curves were applied to determine OGT’s clinical relevance in cancers. The Spearman correlation analysis and enrichment analysis were utilized to explore the underlying mechanisms of OGT in cancers. For the first time in the field, we provide an overview of OGT in 32 cancers using a large number of samples (n = 21,196), determining distinct OGT expression in 25 cancers and its prognosis effects in 12 cancers. Furthermore, using 950 samples from multiple sources, upregulated OGT was found in both mRNA and protein levels in SCLC (SMD = 0.93, 95% CI [0.24, 1.63]). Higher OGT levels represented a more unfavorable disease-free interval for SCLC patients (

p
<
0.001

). The research also identified OGT expression as a potential marker for SCLC prediction (sensitivity = 0.79, specificity = 0.86, and AUC = 0.88). The high expression of OGT in SCLC may result from the positive regulation of two transcription factors—DEK and XRN2. We primarily investigated the underlying mechanisms of OGT in SCLC. Herein, based on the analyses from pan-cancer to SCLC, OGT demonstrated conspicuous clinical significance. OGT may be an underlying biomarker for the treatment and identification of some cancers, including SCLC.
Regulation of ACSL4-Catalyzed Lipid Peroxidation Process Resists Cisplatin Ototoxicity
Authors: He Feinan , Huang Xiaotong , Wei Guokun , Lin Xiaorong , Zhang Weijian , Zhuang Wei , He Wuhui , Zhan Ting , Hu Hai , Yang Haidi
Published: March 2022

Cisplatin-induced ototoxicity is one of the common side effects during its treatment and there are no effective measures to prevent it. Our study aimed to investigate the effect of ACSL4-catalyzed lipid peroxidation on cisplatin-induced hearing loss and its possible protective mechanisms. We used a variety of cisplatin ototoxicity models, including HEI-OC1 cell line, cochlear explants, and ET4 GFP+ zebrafish. After measuring the experimental concentrations of cisplatin by CCK8 assay and immunofluorescence, respectively, we examined the levels of lipid peroxidation by MDA content, 4-HNE content, and C11-BODIPY (581/591) probe. Then, we used two ferroptosis inhibitors, FER-1, and Vit-E to protect hair cells. We found that cisplatin significantly increased the levels of lipid peroxidation and that this process can be resisted by the ferroptosis inhibitors. Afterwards, we performed metabolomic assays on the cisplatin-treated hair cells. The metabolite levels were significantly altered in the experimental group compared to the control group, and the highest degree of change was observed in the glutathione metabolic pathway and the arachidonic acid metabolic pathway. Therefore, we screened the key enzymes on the arachidonic acid metabolic pathway in the hair cells after cisplatin treatment and found that ACSL4 had the greatest regulatory value. Further, we reduced the level of lipid peroxide in hair cells by specifically inhibiting the expression of ACSL4, which protected hair cells from cisplatin damage at source. In conclusion, the lipid peroxidation process regulated by ACSL4 may be an important factor contributing to the sensitivity of hair cells to cisplatin. Inhibition of ACSL4 expression may be an effective preventive measure against cisplatin ototoxicity.
Microgrid Load Forecasting Based on Improved Long Short-Term Memory Network
Authors: Huang Qiyue , Zheng Yuqing , Xu Yuxuan
Published: March 2022

With the fast growing of new energy technologies, the proportion of distributed renewable energy sources dominated by wind and light energy in the microgrid continues to increase. However, the uncertainty and randomness of energy itself bring challenges to the stable operation of the power system. Microgrid load forecasting with high accuracy is the key means to handle the above problems. It can provide help for power grid dispatching and decision-making, optimize resource allocation, reduce operation cost, and ensure system safety. In this paper, a load-forecasting algorithm for microgrid based on improved long short-term memory neural network (LSTM) is proposed. Firstly, the criticality analysis of load influencing factors is carried out, and the clustering classification and weight calculation are completed. Then, the input data is preprocessed to ensure the quality of database. Secondly, the LSTM gets improved from three aspects: multilayer convolution channel, lookahead optimizer, and AM weight. And a complete forecasting model is designed to accomplish the load forecasting. Finally, based on the data of a local microgrid in Zhejiang Province, China, simulation experiments are conducted. The results are quantitatively compared with other forecasting algorithms to verify the accuracy and superiority of the proposed algorithm.
Pretreatment Low Serum Sodium as a Prognostic Factor for Patients with Esophageal Cancer Treated with Radiotherapy or Chemoradiotherapy
Authors: Lu Jianchao , Wang Yi , Lan Mei , Lv Jiahua , Li Tao , Wu Lei , Wang Qifeng , Lang Jinyi
Published: March 2022

Low serum sodium levels have been associated with poor prognoses for several cancers. However, the prognostic value of low serum sodium levels in esophageal carcinoma (EC) has not been well elucidated. We examined the prognostic value of low baseline serum sodium levels before radiotherapy or chemoradiotherapy for EC patients. A retrospective analysis of data from EC patients who received radiotherapy or chemoradiotherapy at a single cancer center was performed. Patients were divided into low serum sodium level (≤140.0 mmol/L) or high serum sodium level (>140.0 mmol/L) groups according to the median pretreatment serum sodium level. The Kaplan–Meier model and Cox proportional hazards model were used for survival analyses. The 5-year progression-free survival (PFS) and overall survival (OS) rates in the whole group were 16.9% and 21.8%, respectively. The PFS and OS rates of patients in the low serum sodium levels group were significantly lower than those in the high serum sodium levels group (

p
<
0.001

). A similar association between PFS/OS and sodium levels was observed in the treatment subgroups. The univariate analysis showed that low serum sodium levels, Karnofsky performance status (KPS), clinical N stage, tumor site, clinical stage, and treatment mode were the influencing factors of OS. Multivariate analyses indicated that low baseline serum sodium levels were an independent prognostic marker of poor PFS (HR, 1.744; 95% CI, 1.248-2.437;

p
=
0.001

) and OS (hazard ratio (HR), 2.125; 95% confidence interval (CI), 1.555-2.904;

p
<
0.001

). Pretreatment levels of low serum sodium could be a new and helpful serum biomarker of the prognosis of EC patients receiving radiotherapy or chemoradiotherapy.
Application of Intelligent Intravenous Drug Dispensing Robot in Clinical Nursing
Authors: Zhang Lifen , Liu Wei , Zhang Yanhong
Published: March 2022

In order to explore the application of intelligent intravenous drug dispensing robot in clinical nursing, the efficiency, residual amount, needle pushing, and pulling times, the incidence of accidental hand stab injury and the accuracy of drug dispensing were compared and observed between intelligent intravenous drug dispensing robot and manual dispensing. The study found that the sterile powder residual amount of injection is pointed out in the standard, the drug label is not equipped with ≤50 mg, and the residual limit is ≤ 15%; the lamination is 50–150 mg, the residual amount is limited to ≤10%; the marking is 150–500 mg, the residual amount is ≤ 7%; the marking is 500 mg, the residual amount is limited to ≤5%; 6 months of artificial deployment accidental stab ergonomics occur; without this phenomenon when using the drug‐like robot, 6 months internal use of the pharmaceutical robot, 4 times of error occurrence, and errors occurred 60 times. During the clinical intravenous infusion dispensing process, the use of intelligent vein is used to configure the robot, improve the efficiency of the drug, reduce the incidence of drug residual, reduce the incidence of dispensing, increase the accuracy and safety of venous liquidation, and decrease to some extent professional injury caused by drug formulation for liquid nurses.
Study on the Solution of Sand Slabbing in the Tailing Sand Bin of Huanggang Iron Ore Mine
Authors: Zhu Xin , Zheng Bokun , Peng Liang , Wu Fengfeng , Yin Xuyan , Liu Yang , Yang Xin
Published: March 2022

In order to improve the tailings utilization rate and realize full tailings’ filling in Huanggang iron mine in Inner Mongolia, a flocculation settlement system was added, which resulted in silting and consolidation of tailings in sand silts. Based on this, the reason for the deposition and caking of tailings was obtained through analysis, and a set of coarse and fine tailings bin filling system was proposed. The tailings of the plant were pumped to the filling station by slurry pump. Firstly, the tailings with large particle size difference were divided into coarse tailings and fine tailings by hydrocyclone so that the fine tailings entered the No. 1 sand bin and the coarse tailings entered the No. 2 sand bin. Then, flocculant was added by automatic flocculant dosing device to flocculate and settle the coarse and fine tailings, and then, it was mixed, stirred, and filled into the well. The results showed the following. (1) The particle size difference of tailings in Huanggang Iron mine increased and resulted in unstable flocs. The coarse tailings settled to the bottom of the silo before the fine tailings, and the compression time was too long, leading to the phenomenon of silting and consolidation. (2) Flocculation and settlement of coarse and fine tailings in different sand silos can avoid deposition and compaction of tailings in sand silos. (3) According to the different requirements of the concentration and ratio of the filling slurry, the proportion of coarse sand and fine sand in the filling slurry can be controlled by controlling the flow size of the coarse sand and fine sand chamber, to achieve the design of reasonable particle size composition and concentration requirements. The research results are expected to provide technical support and theoretical guidance for the construction of full tailings cemented filling system in Huanggang iron mine.
Evaluation of Women’s Entrepreneurship Education Based on BP Neural Network
Authors: Zhao Xi , Lin Chunyi , Wang Shuangguo , Zhao Henan
Published: March 2022

Entrepreneurship education is the key to cultivating the entrepreneurial spirit of national talents. The goal of entrepreneurship education is to cultivate a large number of pioneering talents, and women’s entrepreneurship education is particularly important. The government, enterprises, schools, and all sectors of society start from multiple channels to let students strengthen their entrepreneurial awareness and improve their entrepreneurial ability. This paper uses the most advanced BP neural network algorithm to study and evaluate women’s entrepreneurship education. This paper briefly introduces the concept and model of the artificial neural network and establishes a BP neural network model while improving the classical BP neural network. Then, we list the application process of the BP neural network model in evaluating women’s entrepreneurship education. We select college students for empirical analysis, determine the number of neurons, and select 9 items as the evaluation index of women’s entrepreneurship education. Using valid assumptions, we further determine the model learning rate and momentum factor. Finally, the results show that the actual evaluation results based on the BP neural network are basically the same as the expected results, and the maximum relative error between the actual value and the expected value is approximately 1.64 %, and the comprehensive evaluation value is 92 points. The proposed algorithm can effectively avoid the problems of instability and slow convergence of the traditional model and can comprehensively improve the accuracy of the evaluation results of women’s entrepreneurship education.
Current Status of Fear of Disease Progression in Patients with Advanced Cancer and Usefulness of Dignity Therapy Intervention
Authors: Zhang Yongli , Zhou Fangru , Yang Hong , Gong Xue , Gao Jingfang
Published: March 2022

With changes in lifestyle and an increase in bad health habits, cancer has become a noncommunicable and frequently occurring disease that poses a serious threat to human life. Cancer is associated with high rates of morbidity and mortality worldwide. As a major negative life event, advanced malignancies lead to strong mood swings in most patients. Furthermore, various internal and external factors can have a huge impact on patients’ physical and mental health and put them in a stressful situation, causing a series of psychological stress responses. To explore the degree of fear of disease progression in patients with advanced cancer and the usefulness of dignity therapy. Overall, 120 patients with advanced malignant tumors admitted to Shijiazhuang No. 1 hospital between January 2019 and January 2020 were enrolled. The selected patients were divided into the test and control groups (60 people per group) using a random number table. All patients received basic treatment. Patients in the trial group also received dignity therapy. The intervention period was 4 weeks. Simplified scales were used for assessing disease progression (FoP-Q-SF) and quality of life (QLQ-C30) before and after the intervention, and the scores were compared between the groups. After the intervention, the degree of fear in the experimental group was lower than that of the control group. Cognitive function, emotional function, and the scores of the overall health status of the experimental group were higher than those of the control group. Additionally, the scores of fatigue, insomnia, loss of appetite, and diarrhea in the experimental group were lower than those of the control group (

P

 < 0.05). The social support level scale scores, depression scores, hospital anxiety and depression scale scores, and patient dignity inventory scores of the experimental group were lower than those of the control group (

P

 < 0.05). Patients with advanced malignant tumors have fear, anxiety, and depression related to disease progression. Dignity therapy is useful for improving the patients’ quality of life, increasing dignity, and enhancing social support.
Solutions of Some Kandasamy–Smarandache Problems about Neutrosophic Complex Numbers and Group of Units’ Problem
Authors: Abobala Mohammad , Hatip Ahmed , Olgun Necati
Published: March 2022

Neutrosophic complex numbers are a novel interesting generalization of classical complex numbers. This study aims to study the neutrosophic complex infinite rings, where we classify those rings as direct products by using classical complex field C. Also, this work introduces full solutions for 18 Kandasamy–Smarandache open problems concerning these structures, as well as the group of unit’s famous problem, where the group of units (invertible elements) of a neutrosophic complex ring will be classified as a direct product of two classical groups of units.
Genomic Designs of rAAVs Contribute to Pathological Changes in the Livers and Spleens of Mice
Authors: Mulcrone Patrick L. , Zhang Junping , Pride P. Melanie , Lam Anh K. , Frabutt Dylan A. , Ball-Kell Susan M. , Xiao Weidong
Published: March 2022

Recombinant AAV (rAAV) gene therapy is being investigated as an effective therapy for several diseases including hemophilia B. Reports of liver tumor development in certain mouse models due to AAV treatment and genomic integration of the rAAV vector has raised concerns about the long-term safety and efficacy of this gene therapy. To investigate whether rAAV treatment causes cancer, we utilized two mouse models, inbred C57BL/6 and hemophilia B Balb/C mice (HemB), to test if injecting a high dose of various rAAV8 vectors containing or lacking hFIX transgene, a Poly-A sequence, or the CB or TTR promoter triggered liver fibrosis and/or cancer development over the course of the 6.5-month study. We observed no liver tumors in either mouse cohort regardless of rAAV treatment through ultrasound imaging, gross anatomical assessment at sacrifice, and histology. We did, however, detect differences in collagen deposition in C57BL/6 livers and HemB spleens of rAAV-injected mice. Pathology reports of the HemB mice revealed many pathological phenomena, including fibrosis and inflammation in the livers and spleens across different AAV-injected HemB mice. Mice from both cohorts injected with the TTR-hFIX vector demonstrated minimal adverse events. While not tumorigenic, high dose of rAAVs, especially those with incomplete genomes, can influence liver and spleen health negatively that could be problematic for cementing AAVs as a broad therapeutic option in the clinic.
Nanoconjugation between Fungal Nanochitosan and Biosynthesized Selenium Nanoparticles with Hibiscus sabdariffa Extract for Effectual Control of Multidrug‐Resistant Bacteria
Authors: Al-Saggaf Mohammed S.
Published: March 2022

Multidrug‐resistant (MDR) pathogenic bacteria are hazardous and ongoing threats worldwide, which urges searching for novel bioeffectual alternatives for combating MDR attacks. Herein, it was targeted to extract chitosan (Cht) from fungal culture (Mucor circinelloides) and transform it to nanochitosan (NCht), to biosynthesize selenium nanoparticles (SeNPs) directly using Hibiscus sabdariffa extract (HbE), and to conjugate these bioactive agents and assess their biocidal actions against MDR bacterial pathogens (Klebsiella pneumoniae, Salmonella typhimurium, and Staphylococcus aureus). The fungal Cht had 86.71% deacetylation and transformed effectually to NCht with a 67.6 nm average particle diameter. The SeNPs were innovatively and simply biosynthesized by direct interaction with HbE, which were validated visually, calorimetrically, and biochemically; the HbE/SeNPs had a 12.1 nm mean size. The conjugation between NCht and HbE/SeNPs was proven via structural and biochemical analysis. The entire fabricated NPs/nanocomposites exhibited elevated bactericidal actions toward all MDR pathogens; NCht/HbE/SeNPs were the most powerful with the widest growth inhibition zones and minimal bactericidal concentrations. The most sensitive bacteria were K. pneumoniae, whereas S. aureus displayed the utmost resistance. The ultrastructure of treated K. pneumoniae with NCht/HbE/SeNPs evidenced the attachment of nanocomposite particles to bacterial membranes and the full bacterial lysis/death within 8 h of exposure. The compositing of NCht with HbE‐biosynthesized SeNPs provided powerful ideal bactericidal conjugates against MDR pathogens with warranted biosafety, eco‐friendliness, and effectuality.
Feature Extraction of Weak-Bearing Faults Based on Laplace Wavelet and Orthogonal Matching Pursuit
Authors: Hou Lei , Zhao Junxiao , Dun Shiwei , Cai Yufeng , Yang Yang , Xu Junzhi , Sun Chuanzong
Published: March 2022

The transient impact component of early bearing faults is not obvious, and the traditional basis function expansion method is poor in feature extraction under strong noise conditions. In this paper, a transient feature extraction technique is proposed based on Laplace wavelet and orthogonal matching pursuit algorithm and combined with sparse representation theory. First, the overcomplete and redundant Laplace wavelet dictionary is adopted to represent vibration signals in a sparse way. Then the Hilbert resonance demodulation method is employed to obtain the envelope spectrum of sparse representation signal. Finally, the coefficient calculation problem of sparse representation is solved by orthogonal matching pursuit (OMP) algorithm. Simulation examples and experimental example are used to examine the performance of the proposed method. The results show that the weak-bearing faults feature extraction can be effectively realized since the transient shock component can be identified. Furthermore, the effectiveness of the proposed method is verified by the cyclic multishock simulated signals as well as the practical rolling-bearing vibration signals. Moreover, the comparison studies are also carried out to show that the proposed method outperforms the traditional basis function expansion methods in weak fault feature extraction of bearing.
Analysis of Related Risk Factors of Microvascular Invasion in Hepatocellular Carcinoma
Authors: Shi Longqing , Qu Zhen , Yang Yue , Zhang Yue , Sun Donglin
Published: March 2022

Objective. To forecast the onset of microvascular invasion (MVI) in patients with hepatoma by evaluating the preoperative aspartate aminotransferase-to-platelet ratio index (APRI), alpha-fetoprotein (AFP), neutrophil-to-lymphocyte ratio (NLR), and other clinicopathological data. Methods. In this study, we retrospectively analysed the clinical data of 62 patients who received radical surgery for hepa toma from 2019 to 2021. Patients were separated into the MVI-negative group and the MVI-positive group according to the postoperative pathological diagnosis. The relationships between MVI and NLR, APRI, AFP, tumor size, and other clinical data were assessed using the univariate analysis, receiver operating characteristic (ROC) curve, least absolute shrinkage and selection operator (LASSO) analysis, and logistic analysis. Results. The ROC curve determined that the cutoff values of NLR, platelet-to-lymphocyte ratio (PLR), and APRI were 1.520, 98, and 0.275, respectively. The univariate analysis showed that the MVI-positive result was associated with five factors: tumor size (

χ

2

=
10.620

,

p
=
0.001

), AFP (

χ

2

=
10.524

,

p
=
0.001

), Edmondson grade (

χ

2

=
20.736

,

p
<
0.001

), NLR (

χ

2

=
8.744

,

p
=
0.003

), and APRI (

χ

2

=
4.849

,

p
=
0.028

). The LASSO analysis indicated that the risk factors were the number of tumors, PLR, APRI, NLR, AFP, Edmondson grade, and tumor size. The multivariate logistic regression analysis showed that

NLR
≥
1.520

(OR 11.119,

p
=
0.006

),

APRI
≥
0.275

(OR 12.515,

p
=
0.009

),

AFP
≥
200

 μg/mL (OR 7.823,

p
=
0.016

), and tumor

size
>
3

 cm (OR 7.689,

p
=
0.022

) were independent risk factors for MVI in patients with hepatoma. Conclusion. Preoperative NLR, APRI, AFP, and tumor size are reliable indicators for predicting the appearance of MVI in patients with hepatoma and are of great value in making detailed and reliable treatment protocols for these patients before surgery.
Relationship between Surface Subsidence Range and Geological Mining Conditions Using Numerical Simulation and Machine Learning
Authors: Zhang Yanjun , He Fushuai , Kong Jiayuan , Zhu Yuanhao , Wang Lingfei
Published: March 2022

With the increase of mined-out areas and geological disasters, it is necessary to study the influence range of mining. Moreover, with the growth in the amount of data, machine learning methods are commonly used to predict the surface subsidence. The 10 mm subsidence boundary is an important indicator to determine the influence range, and FLAC3D is suitable for solving the nonlinear large deformation problems. Therefore, it can be used to explore the relationship between the influence range of the surface movement (L) and geological mining conditions. Taking working faces A and B of two mines, through the establishment of a numerical model, the relationship between L and bedrock thickness, loose layer thickness, working face mining length, and overlying rock lithology is explored by using the control variable method. Moreover, the variation law is analyzed theoretically and mechanically. The results show that L is positively correlated with the thickness, while negatively correlated with the mining length. Similarly, L shows a slight increase after the key layer becomes weak. This study provides a scientific basis for reasonable coal mining and protection of surface buildings in the mining area. Integrating machine learning into the numerical model further increases the model throughput. The findings show that machine learning models had high accuracy in predicting surface subsidence, with the random forest trees and regression models having lower time and high accuracy, respectively.
Multiattribute Group Decision‐Making Method in terms of Linguistic Neutrosophic Z‐Number Weighted Aggregation Operators
Authors: Ye Jun , Yong Rui , Du Shigui
Published: March 2022

To make a fuzzy value more reliable, Zadeh presented the notion of Z‐number, which reflects a fuzzy value related to its reliability measure. Since linguistic expression conforms to human thinking habits, linguistic neutrosophic decision‐making is one of the key research topics in linguistic indeterminate and inconsistent setting. In order to ensure the reliability of multiattribute group decision‐making (MAGDM) problems in the linguistic environment of truth, falsehood, and indeterminacy, we require a new linguistic neutrosophic framework that combines the decision‐maker’s linguistic neutrosophic judgment with its reliability measure. Inspired by the linguistic Z‐numbers of the truth, falsehood, and indeterminacy, this article first proposes a linguistic neutrosophic Z‐number (LNZN) to make the truth, falsehood, and indeterminacy linguistic values more reliable. Then, we define the operational relations, score and accuracy functions, and sorting laws of LNZNs. Next, we establish the LNZN weighted arithmetic mean (LNZNWAM) and LNZN weighted geometric mean (LNZNWGM) operators and indicate their properties. Furthermore, an MAGDM approach is developed based on the two aggregation operators and the score and accuracy functions of LNZNs in the LNZN setting. Lastly, an MAGDM example of industrial robot selection and comparison with existing related methods are provided to verify the applicability and efficiency of the developed MAGDM method in the setting of LNZNs. In general, the developed MAGDM approach not only makes the MAGDM information more reliable but also solves MAGDM problems under the environment of LNZNs.
Topical Corticosteroid-Induced Adrenal Insufficiency: A Case Report
Authors: AlQadri Nada Ghazi , Aljomah Nouf , Alotaibi Hend M.
Published: March 2022

Topical Corticosteroids (TCS) are the most commonly prescribed medications in Dermatology practice. They are considered safe and effective if used at the appropriate location and for the appropriate duration. Local side effects due to TCS are not uncommon. However, systemic side effects are rare. Herein, we present a patient who developed adrenal insufficiency secondary to the use of TCS.
Coexistence of Light- and Heavy-Chain Deposition Disease and Immunotactoid Glomerulopathy in a Patient with Multiple Myeloma: A Case Report
Authors: Liang Yaoxian , Dong Bao , Jiang Lei , Li Xin , Shao Chunying , Yan Yu , Zuo Li
Published: March 2022

Multiple myeloma is a malignant neoplasm leading to a variety of renal diseases. Although most patients have only one pattern of renal pathology, two or more patterns can exist in some patients. Here, we report a 61-year-old man with multiple myeloma developed proteinuria, hematuria, hypertension, and renal insufficiency. A combined presentation of light- and heavy-chain deposition disease and immunotactoid glomerulopathy was proved by kidney biopsy. Treatment of multiple myeloma resulted in a complete resolution of the renal manifestations. This case illustrates the complexity of paraprotein associated renal lesions and emphasizes that further studies examining the physiologic properties and pathologic effects of monoclonal immunoglobulin are needed.
Recurrent Appendicitis: Torsion Detorsion of the Appendix
Authors: Kyriakos Saad Melissa , Aoun Rami , Ghandour Fatme , Saikaly Elias
Published: March 2022

By definition, recurrent appendicitis is recurring right lower quadrant pain, similar to previous attacks of pain subsiding after appendectomy. The pathophysiology of recurrent appendicitis is unclear; however, it is thought to be due to the partial or transient obstruction of the appendix. We believe that primary torsion and spontaneous detorsion of the vermiform appendix is one of the etiologies for recurrent appendicitis, which to our knowledge has not been previously described in the medical literature. Herein, we present a case of a 30-year-old male patient with recurrent appendicitis due to primary torsion and spontaneous detorsion of the vermiform appendix treated by laparoscopic appendectomy.
Complex Germline K757N Mutation in Non-Small-Cell Lung Cancer: A Case Report
Authors: Wong Boaz , Moore Sara , Wheatley-Price Paul
Published: March 2022

Epidermal growth factor receptor (EGFR) mutations are usually oncogenic drivers of lung tumor development and progression. While common sensitizing mutations respond well to targeted therapy, the relevance of germline EGFR mutations is less clear. We describe a 65-year-old, previously healthy, male diagnosed with non-small-cell lung cancer. Familial history for lung cancer is negative. Targeted next-generation sequencing on the tumor biopsy sample revealed an atypical EGFR K757N mutation at 50% allele frequency and genetic review of a previously acquired gastric sample confirms the mutation as a germline change. He received standard first-line chemoimmunotherapy with carboplatin, pemetrexed, and pembrolizumab, and after 8 months therapy continues, with stable disease, to receive maintenance pemetrexed and pembrolizumab. To our knowledge, this is the first report of an atypical, germline K757N EGFR mutation. While the clinical relevance of this mutation is unclear, standard reporting of the allelic frequency of novel, atypical mutations can detect potential germline changes.
Study of Nonperfusion Area Changes after Ranibizumab Intravitreal Injection for Diabetic Macular Edema by Means of Widefield OCT Angiography
Authors: Toto Lisa , D’Aloisio Rossella , Libertini Daniele , D’Onofrio Giada , De Nicola Chiara , Mastropasqua Rodolfo , Chiarelli Antonio Maria
Published: March 2022

Introduction: The aim of this study was to evaluate changes in retinal capillary nonperfusion areas (RCNPA) and the retinal capillary vessel density (RCVD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) using widefield optical coherence tomography angiography (WFOCTA) in patients with diabetic retinopathy (DR) and diabetic macular edema (DME) treated with intravitreal ranibizumab injection (IRI). Materials and Methods: Twenty-four eyes of 24 patients with DR and DME candidates to a loading dose of IRI were enrolled. All patients underwent WFOCTA with the PLEX Elite 9000 device with 15 × 9 mm scans centered on the foveal center at baseline (T0) and 1 month after each intravitreal injection at 30 days (T1), 60 days (T2), and 90 days (T3). In all patients, the variation of RCNPA and the RCVD of the SCP and DCP were calculated using automatic software written in MATLAB (MathWorks, Natick, MA, USA). Results: The SCP showed a significant longitudinal variation of RCNPA (p = 0.04). Post hoc analysis revealed a statistically significant reduction of RCNPA at T1 (p = 0.04) and a nonsignificant reduction at T2 (p = 0.18) and T3 (p = 0.96). The DCP showed longitudinal changes in the RCNPA that tended to statistical significance (p = 0.09). Post hoc analysis revealed a trend toward a statistically significant reduction of RCNPA at T3 (p = 0.09) not statistically significant at T1 (p = 0.17) and T2 (p = 0.75). The RCVD of SCP and DCP showed no significant changes at any of the time points. Conclusions: WFOCTA showed a decrease in RCNPA after IRI, probably related to the reperfusion of retinal capillaries.
Intralesional Avirulent Bacillus Calmette-Guérin Injection as a Promising Method for the Treatment of Tuberculosis Verrucosa Cutis
Authors: Gündüz Özgür , Koçak Gülşah , Kaçmaz Birgül , Devrim Tuba , Şimşek Hülya
Published: March 2022

Cutaneous involvement is a relatively uncommon manifestation of tuberculosis (TB), particularly outside the endemic regions. Cutaneous TB manifests itself in various clinical forms, depending on the host’s immune status and mode of transmission. Nonetheless, the same treatment regimen is recommended for every subtype. Tuberculosis verrucosa cutis (TBVC) is a specific subgroup in which the affected persons are usually healthy adults who are vaccinated or exposed to mycobacteria during their occupational activities. These patients have the ability to launch a strong cellular immune reaction against mycobacteria. In this article, we present an elderly patient with a 4-year history of TBVC who was treated with intralesional injection of avirulent Bacillus Calmette-Guérin (BCG) and report our clinical observation on the inflammatory and healing process of the patient’s lesion following the intralesional BCG injection.
MiR-199a-3p Overexpression Suppressed Cell Proliferation and Sensitized Chronic Myeloid Leukaemia Cells to Imatinib by Inhibiting mTOR Signalling
Authors: Liu Xin , Cui Miao-Miao , Zhu Hai-Zhen , Fu Pei-Yi , Wang Guo-Chuan , Huang Ling
Published: March 2022

Introduction: Chronic myeloid leukaemia (CML) is a myeloproliferative neoplasm characterized by constitutive activity of the tyrosine kinase BCR-ABL1. Drug resistance remains one of the major challenges in CML therapy. MicroRNA (miR)-199a-3p plays an important role in many tumours but has rarely been investigated in CML. We aimed to analyse the role and mechanism of miR-199a-3p in regulating imatinib resistance in CML. Methods: The expression of miR-199a-3p and mammalian target of rapamycin (mTOR) in the serum of CML patients and CML cells was examined by quantitative real-time polymerase chain reaction. The levels of apoptosis-related proteins were determined using western blot. The relative cell survival rate and cell proliferation were determined using a CCK-8 assay and a bromodeoxyuridine (BrdU) assay, respectively. Cell cycle and apoptosis were analysed using flow cytometry. Moreover, a dual-luciferase reporter assay was performed to verify the correlation between miR-199a-3p and mTOR. Results: MiR-199a-3p was downregulated in the serum of CML patients and in CML cells, while mTOR was upregulated. Both miR-199a-3p overexpression and mTOR silencing inhibited CML cell proliferation, promoted CML cell apoptosis, and sensitized these cells to imatinib. mTOR silencing reversed the promoting effect of miR-199a-3p inhibition on the proliferation of CML cells and the inhibitory effects on cell apoptosis and sensitivity to imatinib. MiR-199a-3p directly targeted mTOR. Conclusion: MiR-199a-3p suppressed cell propagation, facilitated apoptosis of CML cells, and sensitized CML cells to imatinib by downregulating mTOR signalling.
Teaching Cariology in Asia and Arabia
Authors: Splieth Christian H. , Abudrya Mohamed Hassan , Anandakrishna Latha , Cheng Lei , Al-Khalifa Khalifa S. , Kim Baek-Il , Kuzmina Irina , Tarabaih Ahmad , Salami Anas , Elhamouly Yasmine , Schmoeckel Julian
Published: March 2022

The European Organisation for Caries Research education platform 2020 had the aim to assess the undergraduate curriculum in cariology in Asian and Arabian countries in order to support structured teaching of cariology in these countries with about almost half of the global population. Representatives of 4 Asian and 4 Arabian countries completed a comprehensive questionnaire on structure of dental education in their country in general and the extent, the content, the responsibilities, structure and standardization regarding cariology in particular. In spite of a wide range from very few universities (Lebanon 3) to larger numbers of dental schools (India 313, China 121, Russia 52) there were similar statements on the list of content for cariology teaching. Often the catalogue was close to the Undergraduate Core Curriculum in Cariology (UCCC) covering most of the 5 domains from basic science to dental public health, but a national curriculum for cariology or dentistry was mostly missing. With various departments being involved, a need of coordination is obvious. Most representatives thought it possible and feasible to teach a standardized curriculum in cariology on the basis of the UCCC. In conclusion, many Arabian and Asian countries have implemented modern, evidence-based curricula in their universities, but an obligatory national curriculum in cariology would be advisable to standardize the quality in teaching.
Conversational Implicature Between Students in Deutsch Für Tourismus With Rollenspiel Technique
Authors: Harahap Herlina Jasa Putri , Reza Muhammad
Published: March 2022

This research examined the violation of the principle of cooperative conversation with data sources from conversations among students in the course Deutsch für Tourismus with a learning model using the Rollenspiel teaching method. Besides aiming to describe and categorize forms of violation of the principle of cooperative conversation, this study also aimed to describe the types of conversational implicatures that arise from violations of the principle of cooperative conversation. The method used is a qualitative method with descriptive elaboration using the theory of the principle of cooperative conversation by Grice and the theory of conversational implicatures by Yule. Based on the analysis found 25 utterances containing violations of the principle of cooperative conversation. Violations of the principle of cooperative conversation include violations of the maxim of quantity with 8 data, violations of the maxim of quality with 6 data, violations of the maxim of relevance with 8 data, and violations of the maxim of manner with 3 data. The conversations among students, it contains often more information than is needed and does not provide relevant contributions. Three types of conversational implicatures arise from the violation of the principle of cooperative conversation, namely: 5 types of general conversational implicatures, 2 types of scaled conversational implicatures and the dominant ones are the specific conversational implicatures with a total of 21 because the conversations among students occur often requires special knowledge in understanding the context.
The Fenomenal World in magical Realism according to Wendy B. Faris in Novel “Das Parfum” by Patrick Süskind
Authors: Sugiarti Yati , Malia Lia , Sahayu Wening , Setiawan Akbar Kuntardi
Published: March 2022

The aim of this study is to discuss the phenomenal world in magical realism according to Wendy B. Faris in the novel “Das Parfum” by Patrick Süskind. The phenomenal world is the presence of phenomenal world whose objects, places, figures, time and events in narrative texts have the characteristics of magical realism. It is explicitly and convincingly described in the story, but it does exist in reality. The phenomenal places in both the investigative novel and in reality describe phenomenal objects and phenomenal events. The phenomenal characters and time cannot be found in this novel.
Using Google Docs in German as Foreign Language Writing Course during the Covid-19 Pandemic
Authors: Hendra Dani
Published: March 2022

Writing and speaking are related. Of the four language skills, there are two productive skills, namely writing and speaking. Learning to write takes a lot of time and can therefore lead to ineffective teaching in the classroom. Self-study outside of class would be a possible solution so that students could always practice their language skills and apply what they have learned. In this pandemic, where learning is only possible online, an application is needed to replace the activities done in the face-to-face phase. These activities can be done anywhere as long as there is an internet connection. The internet is no stranger to the students themselves. They grew up with it at the time, so it should be easy to deal with. Technology is currently developing at a rapid pace. Technological developments create new applications that are useful in the classroom. The search engine, google, provides many applications through which interaction among students or between students and lecturers could take place. One of the applications present in google is google docs. The students do the writing tasks on google docs. Not only can the tasks be found on google docs, but the comments and suggestions for improvement can also be read here. This encourages students to actively participate. This letter shows how the students interact, what mistakes the students make when writing and how they correct it themselves.
Light Verb Constructions in German and Their Equivalents in Thai: A Contrastive Analysis through the Example of the Constitutional Texts
Authors: Jutunka Natchapol , Attaviriyanupap Korakoch
Published: March 2022

The present article is a contrastive analysis that deals with light verb constructions in German and their equivalents in Thai. The purpose of the study is to answer the following questions: 1) Which light verb constructions occur in the constitutional texts? How can they be categorized?; 2) Which forms occur in Thai as equivalents of German light verb constructions? How can they be categorized?; 3) What is the difference between the use of the light verb constructions in the original German text and in the German translation text?; 4) What is the difference between the use of the Thai equivalents of German light verb constructions in the original Thai text and in the Thai translation text? For the analysis, a bidirectional parallel corpus consisting of constitutional German and Thai texts and their translation into the other language was used. The results of this contrastive study can explain both differences and similarities between the two languages and the original and translated texts, such as morphological forms, active and passive meaning, and degree of structural strength, including the most frequently occurring light verb constructions and light verbs in the constitutional texts. In addition, it was found that Thai equivalents have a greater variety and the proportion of passive meaning in German is a little larger than in their Thai equivalents
Neuro-symbolic Natural Logic with Introspective Revision for Natural
Language Inference
Authors: Feng Yufei , Yang Xiaoyu , Zhu Xiaodan , Greenspan Michael
Published: March 2022

We introduce a neuro-symbolic natural logic framework based on reinforcement learning with introspective revision. The model samples and rewards specific reasoning paths through policy gradient, in which the introspective revision algorithm modifies intermediate symbolic reasoning steps to discover reward-earning operations as well as leverages external knowledge to alleviate spurious reasoning and training inefficiency. The framework is supported by properly designed local relation models to avoid input entangling, which helps ensure the interpretability of the proof paths. The proposed model has built-in interpretability and shows superior capability in monotonicity inference, systematic generalization, and interpretability, compared with previous models on the existing datasets.
The Language Question in Şalom (1947–1983): Linguistic Ideologies among the Sephardim of Turkey
Authors: Martínez Corral Adrián
Published: March 2022

Since the beginning of the Judezmo press in the second half of the nineteenth century, “the language question” has been a recurrent topic of debate. Throughout the pages of the many newspapers in Judeo-Spanish, several linguistic ideologies were exposed, often causing heated controversies. The aim of this article is to analyze the views, assumptions and conceptions regarding the many languages employed by the Sephardim of Turkey during the second half of the twentieth century. Şalom, a Judezmo newspaper published in Istanbul from 1947 onwards, will be the source informing this analysis. Finally, it will be observed whether such linguistic ideologies had an impact on the domains of use of the languages employed by Turkish Jewry and helped to conform the current linguistic landscape of the community.
“Then the Conscience of Humanity Arose”: Kishon and the Nations of the World
Authors: Nevo Gideon
Published: March 2022

For many years, humorist Ephraim Kishon diligently brandished his satirical whip at Israel’s socio-economic socialist structure, while vividly portraying the vicissitudes of the Israeli ‘homo economicus’ in the labyrinth of modern life. This line of writing brought him his fame, both in Israel and abroad. At the later stages of his career though, a significant portion of his work was dedicated to the relationship between Israel and its neighbors and between Israel and the world. In this area Kishon has articulated and cemented a stern nationalistic worldview. A systematic analysis of this worldview is a matter for several articles. In this article I will focus on Kishon’s treatment of national entities that are not part of Israel’s immediate circle of confrontation (i.e., its neighboring Arab states) but are rather scattered far and wide all over the world.
Dynamics of Remembrance across Time and Media: On Ruth Glasberg Gold’s Multiple Accounts of Her Holocaust Experiences in Transnistria
Authors: Mihăilescu Dana
Published: March 2022

This article considers the dynamics of the memories of World War II for survivors who give multiple accounts of their experiences over time. I compare five testimonies with different medial content given in 1944, 1983, and 1996 by Ruth Glasberg Gold. In November 1941, at the age of eleven, she was deported with her parents and brother from Czernowitz to the Bershad ghetto, Transnistria, where she lost her family and was orphaned. My major interest is to examine how Glasberg Gold’s memories over time intersect with changes of medium, location, language, and temporal context, and might have brought different or similar emphases in her written, audio, and video testimonies of the Holocaust. I believe her case to be important for scholarly analysis as it allows one to explore how the developing personality of a Holocaust survivor and changing media environments intersect and relate to how memories of the Holocaust become shaped, rehashed, and modified over time.
Review of the millipede genus Propyrgodesmus Silvestri, 1920, with the description of a new species from a sacred grove in Kerala, India (Diplopoda: Polydesmida: Pyrgodesmidae)
Authors: ASWATHY MATHILAKATH DASAN , SUDHIKUMAR AMBALAPARAMBIL VASU
Published: March 2022

The endemic Indian genus Propyrgodesmus is reviewed, rediagnosed and shown to presently comprise three species, all illustrated, keyed and mapped, including P. bulbogonopus sp. nov., from a sacred grove supporting a semi-evergreen vegetation in Kerala, southern India. The new species differs from their congeners, P. lobulatus Silvestri, 1920 (the type species) and P. frater Carl, 1932, mainly by tergal ornamentations and, when known, some significant details of gonopodal structure.