bluuebunny/crossref_metadata_2025 huggingface dataset:
A case laboratory study on effect of quarry dust based geopolymer on physical and mechanical properties of laterit soil
Authors: Bui Duc Van , Dao Lam Phuc , Nguyen Manh Van , Nong Anh Quoc , O. Kennedy ,   Civil Engineering Faculty, Hanoi University of Mining and Geology, Vietnam  Civil Engineering Faculty, University of Transport Technology, Vietnam  Bac Kan City Department of Transportation and Communication, Vietnam Department of Civil Engineering, Michael Okpara University of Agriculture, Umudike, P. M. B. , Umuahia 00, Abia State, Nigeria
Published: March 2021

This paper presents a case study on the laboratory examination of quarry dust based geopolymer on some physical and mechanical properties of stabilized laterit soil. The laboratory test results indicate that both CBR and shrinkage limit of studied soil increased substantailly with increased rate of quarry dust based geopolymer (QD-based geopolymer). Specifically, the laterit soils were treated with QD-based geopolymer in the proportions of 10%, 20%, 20%, 30%, 40%, 50%, 60%, respectively, by weight of dry soil; the CBR values were increased from 7.4% to 35.71% at proportion of 40% QD-based geopolymer. The obtained CBR value of 35.71% meets the requirement to be used as filled meterials for pavement purpose according to the TCVN 8857:2012. In constrast with the increase in CBR and shrinkage values, the swelling potential of treated soils was found to be decreased with raising QD-geopolymer proportion, for example, the swelling potential decreased from 14.5÷6.9% as adding 10, and 60% of QD- based geopolymer, respectively .
Research on the possibility of applying concrete using recycled aggregates from waste concrete to build rural roads
Authors: Dang Huy Quang , Hoang Phuc Dinh , Bui Thang Anh , Ngo Trang Huong Thi , Chu Anh Tuan ,   Falculty of Civil Engineering, Hanoi University of Mining and Geology, Hanoi, Vietnam  Academy of Finance, Vietnam
Published: March 2021

Many researchers over the world have pointed out the great economic and environmental benefits of using recycled aggregate from waste concrete to make concrete. In Vietnam, although the demand for concrete is increasing in both civil and infrastructure construction such as rural concrete roads, however, the use of waste concrete aggregate to make concrete still has not been adequately studied. With the experimental test, the authors have studied the change in the strength of concrete using large recycled aggregates, thereby clarifying the possibility of using this type of concrete in rural concrete road construction. The results show that, if the amount of recycled aggregate to replace natural aggregate is below 30%, the concrete strength achieved is slightly reduced compared to the control concrete. As the amount of recycled aggregate increases, the strength of the concrete decreases significantly but still can meet the strength requirement of concrete in rural roads.
Study on the consolidation properties of soft soil distributed in the North Center coastal area of Vietnam
Authors: Bui Son Truong , Nguyen Nu Thi , Pham Tho Duc , Nguyen Duong Thanh ,   Faculty of Geoscience and Geoengineering, Hanoi University of Mining and Geology, Viet Nam

 Faculty of Civil Engineering, Hanoi University of Mining and Geology, Viet Nam
Published: March 2021

Consolidation parameters of soft soil play an important role in calculating settlement and soft soil improvement by vertical drainage method (distance, quantity, treatment time). In this study, using oedometer tests, consolidation parameters of some soft soils in the North Central coastal region, Vietnam are clarified. The research results show that the compression index Cc has a strong relationship with the natural water content, liquid limit, dry unit weight, and void ratio of the soil. The consolidation coefficient significantly depends on the applied pressure level, at the over-consolidation stage (normal stress is less than pre-consolidation pressure), the consolidation coefficient is high. By contrast, at the normal consolidation stage (normal stress is greater than pre-consolidation pressure), the coefficient of consolidation is small. The pre-consolidation pressure of soil changes with the distribution depth.
A COVID-19 E SEUS IMPACTOS NO SISTEMA PRISIONAL EM SERGIPE
Authors: Santos Paulo Roberto Felix dos , Lima Izy Rebeka Gomes , Santos Maria Suelen
Published: March 2021

Diante da situação de crise sanitária, ocasionada pela pandemia da Covid-19, nos marcos da crise do capital, torna-se necessário explicitar como esse cenário impacta a dinâmica prisional, com ênfase na realidade sergipana. O presente artigo tem como objetivo principal proporcionar um processo reflexivo-crítico acerca da configuração do sistema prisional em Sergipe em tempos de pandemia, com uma revisão bibliográfica e pesquisa documental, a partir do materialismo histórico dialético, como método de análise. Identificamos como as condições precarizadas do sistema prisional propiciam a expansão da pandemia, expondo seus(uas) internos(as) às mais variadas violações de direitos e situações de matabilidade. Tais impactos revelam-se mais contundentes perante à juventude negra e pobre, que compõe a maior parte da população prisional, processo que escancara as particularidades da dimensão do racismo estrutural, e do projeto de controle sócio-racial. Ademais, demonstramos algumas das medidas utilizadas para mitigar os efeitos da pandemia nesse espaço que, apesar de importantes, revelam-se limitadas, diante de todo o cenário caótico do cárcere sergipano. Como poderemos perceber, tais elementos explicitam os fundamentos das medidas de aprisionamento e das formas de controle capitalista mobilizadas em face do excedente de força de trabalho, e que no contexto de pandemia tem essa condição agravada nas prisões.
SERVIÇO SOCIAL E COVID-19
Authors: Fontes da Silva Welison Matheus
Published: March 2021

Este artigo objetiva refletir criticamente sobre a pandemia de COVID-19 no Brasil e o Serviço Social, sobretudo a partir da centralidade da atuação no âmbito da saúde, retomando, inclusive, o urgente e necessário debate da reforma sanitária. A introdução analisa a chegada do novo coronavírus ao Brasil e como a profissão encontra espaço para sua ação. Em seguida, apresentamos os significados da pandemia, expondo o abandono de uma parte significativa da população, para logo depois, discutirmos as relações entre pandemia, “questão social” e o projeto ético político do Serviço Social. Os resultados nos mostram que há um inúmeras contribuições de autores do Serviço Social e também de outras áreas das Ciências Humanas que nos ajudam construir a percepção de que, apesar da epidemia do COVID-19 ser um fenômeno global, em função da brutal desigualdade brasileira, esta expõe desafios ainda maiores, por sua configuração a partir de contextos e espaços sociais diversos. Por isso, por fim, indicamos possíveis caminhos para o enfrentamento da crise a partir de uma agenda política.
OS INVISÍVEIS SOCIAIS
Authors: Maciel Pires Isabela , Lane Lopes Silvares Caroline
Published: March 2021

O presente artigo traz uma reflexão sobre a atuação do assistente social e do psicólogo, na política de Assistência Social, mais especificamente no Centro de Referência Especializado de Assistência Social (CREAS) do município de Niterói. Tem como objetivo mostrar os limites e possibilidades de atendimento neste espaço sócio ocupacional, tal como o enfrentamento pela garantia de direitos e acesso aos benefícios sócio assistenciais dos usuários, frente à pandemia do Novo Coronavírusontribuindo para reflexão sobre a atuação do assistente social e do psicólogo neste período de isolamento social. O estudo tem por metodologia a pesquisa bibliográfica e relatos decorrentes do fazer profissional nesse espaço sócio ocupacional.
Queering Methodologies: Challenging Scientific Constraint in the Appreciation of Queer and Trans Subjects
Authors: Ferguson Joshua
Published: March 2021

Qualitative studies require a queer perspective to challenge stagnant forms of scientific discourse. This paper argues for a deconstruction of hegemonic qualitative practices in order to appreciate and listen to queer and trans subjects when employing qualitative research and methodologies. I focus on qualitative methods from an audiovisual perspective to suggest that there is scientific constraint in the way researchers still approach qualitative methodologies. I propose some foundations for thinking about queer qualitative methods that employs queer theory in relation to a self - reflexive creative perspective towards ethics, research and representation. Moreover, I critically analyze the HBO trans documentary, Middle Sexes: Redefining He and She (Antony Thomas 2005), in order to move beyond complacent documentaries that employ interviews as a way of categorizing and containing gender diversity. I work towards future methodological promises for the exploration of queer and trans subjects. Further, this paper challenges the problems of imposing binary - based categories that not only obscure thorough understandings of gender but also perpetuate social injustice.
Picturing Leisure: Using Photovoice to Understand the Experience of Leisure and Dementia
Authors: Genoe Rebecca , Dupuis Sherry
Published: March 2021

Interviews and participant observation are commonly used to explore the experience of dementia, yet may not adequately capture perspectives of persons with dementia as communication changes. We used photovoice (i.e., using cameras in qualitative research) along with interviews and participant observation to explore meanings of leisure for persons with dementia. We discuss our photovoice process and the challenges we encountered, including ethical concerns, difficulty using the equipment, forgetting the context of photos, and questioning self. Despite challenges, photovoice aided in cuing memory, planning for the interview, sharing stories, and capturing meaning. We recommend further exploration of photovoice with this population.
Interviewing Key Informants: Strategic Planning for a Global Public Health Management Program
Authors: Kun Karen , Kassim Anisa , Howze Elizabeth , MacDonald Goldie
Published: March 2021

The Centers for Disease Control and Prevention’s Sustainable Management Development Program (SMDP) partners with low - and middle - resource countries to develop management capacity so that effective global public health programs can be implemented and better health outcomes can be achieved. The program’s impact however, was variable. Hence, there was a need to both engage in a strategic planning process and collect useful data to inform the process. We therefore designed a qualitative evaluation and findings that emerged concerning o ur program’s contribution to individual career advancement and professional growth; the need for institutional support and a champion to move public health management capacity development efforts forward in low - and middle - resource countries; and interest in diverse professional learning opportunities contributed to program improvement and suggested new strategic directions for CDC’s global public health management service delivery. Our inquiry provides a concrete example of how qualitative methods, specifically key informant interviews, can provide useful data for strategic planning within public health settings. It may be useful to readers who are interested in conducting strategic planning within public health and other related areas including health care, mental and behavioral health, and the social sciences.
Guidance on Performing Focused Ethnographies with an Emphasis on Healthcare Research
Authors: Higginbottom Gina , Pillay Jennifer , Boadu Nana
Published: March 2021

Focused ethnographies can have meaningful and useful application in primary care, community, or hospital healthcare practice, and are often used to determine ways to improve care and care processes. They can be pragmatic and efficient ways to capture data on a specific topic of importance to individual clinicians or clinical specialties. While many examples of focused ethnographies are available in the literature, there is a limited availability of guidance documents for conducting this research. This paper defines focused ethnographies, locates them within the ethnographic genre, justifies their use in healthcare research, and outlines the methodological processes including those related to sampling, data collection and maintaining rigour. It also identifies and provides a summary of some recent focused ethnographies conducted in healthcare research. While the emphasis is placed on healthcare research, focused ethnographies can be applicable to any discipline whenever there is a desire to explore specific cultural perspectives held by sub - groups of people within a context - specific and problem - focused framework.
Teacher - Student Relationships in Court - Mandated Adult Education: A Phenomenological Study
Authors: Mottern Ron
Published: March 2021

While there is a considerable body of literature on adult correctional education, this literature almost exclusively deals with teachers and students working within incarceration settings, where students are in jail or prison. There is a lack of research on the experiences of teachers working with students who are a part of the correctional system but are placed within the community , i.e., community corrections. In this study the author examines the experiences of teachers working with court - mandated, community corrections students in GED/ABE programs. Seven adult education teachers share their experiences in this phenomenological study. The findings of the study indicate a special relationship, a chiasm, between teachers and students. Implications of this chiasm, an experience described by Merleau - Ponty, are explored.
INVESTIGATING THE IMPACT OF CONFLICT MANAGEMENT ON EMPLOYEE’S PERFORMANCE: A STUDY BASED ON TOOL BOX OF CONFLICT ANALYZING MODEL BY FURLONG
Authors:   Institute of Business and Technology, Karachi, Tariq Muhammad
Published: March 2021

This study investigated the impact of Conflict Management on Employee’s Performance and implementing the Furlong ‘tool box of conflict analyzing model to find out how conflict will be resolved easily , effectively and improve the overall Employee’s performance. This study developed the survey research design. 200 respondents were selected of different organizations for the study. Questionnaire was used to collect primary data. Hypothesis was tested through regression analysis. The findings of the research revealed that effective management tools develop the employee’s performance in the organization. Furlong tool box of conflict analyzing model provide favorable outcomes in the perspectives of Trust, Behavior, Avoidance and Emotions. The result and outcomes of my research provide a structure and importance of application of Conflict management in cooperation to find out how will minimize the clash between the employees and subordinates for the betterment of the employee’s performance. The other organizations can also get benefits of this research.
WHY LOCAL RESIDENTS HARVEST NATURAL FOREST? DETERMINANTS FACTORS IN THE MOUNTAINS OF KHYBER PAKHTUNKHWA
Authors:   University of Swat, Rabbi Fazli
Published: March 2021

Purpose- - This paper empirically examines households’ forest biomass extraction behavior in three forests areas of Khyber PakhtunKhwa, Pakistan. It further identifies the determinant factors of three types of resources that have implications for forest cover. These include the extraction of fuel wood, cutting of timber and free grazing of goats in the forests. Methodology- - We use primary date collected from 180 households in three forest areas (Miandam, Lalkoo, and Bamburet in the province of Khyber Pakhtunkhwa. The data was gathered in three Miandam, Lalkoo, and Bamburet using two stage sampling technique. Findings- - The results showed that as insecurity of forest ownerships, family size and age of the households increases, households are more likely to opt for fuel wood harvesting from the forests. On the contrary, as education of the household head, no of crops grown in a season distance to market, use of substitute fuel, and plantation on private land outside forest and livestock assets increases, households are less likely to harvest fuel wood from the natural forests. We also find that there cross regional variation in tendency to harvest fuel wood from the forests. The results also reveal that, households tendency to graze in the forest decreases as households’ off-farm income share increases in total households annual income. Practical Implication- - The government forest policy and conservation efforts need to prioritize the provision of alternative fuel sources, community plantation. Policy strategies are needed to regulate free grazing of goats socially in the state owned natural forests in the province. The areas in the periphery of the natural forests should be supplied with sources of energy from substitute sources such as hydroelectric powers, launch community plantation programs vis-à-vis legislate to resolve the issue of dispute of forest ownership to realize the goal of sustainable utilization of forest and socioeconomic development of the mountains regions.
Implementing Open Data Strategies for Climate Action: Suggestions And Lessons Learned for Government and Civil Society Stakeholders
Authors: Grinspan Delfina , Worker Jesse
Published: March 2021

Shared data and information are fundamental to mainstreaming climate action and promoting a coordinated and coherent response to climate change across government and society. Open data—the publication of datasets that can be freely used and redistributed by anyone, anywhere—offers opportunities to ensure climate policymaking is informed by all relevant data while building trust with civil society and enabling data users to create valuable tools and visualizations that can broaden impact and engage new audiences. This working paper aims to promote greater accessibility of climate-related data by building government officials’ and other stakeholders’ understanding of the benefits of open data practices for climate action, potential challenges, and ways to address these challenges while taking steps to ensure that data publication is impactful, responsible, and sustainable. It draws on a literature review, expert consultations, and observations from pilot projects implemented in Chile and Uruguay to provide insights for contexts with a range of data capacities, from those with mature data collection and publication protocols to those investing in new data generation processes.
The Conservation of African Elephants under the CITES International Ivory Trade Ban
Authors: Chakanyuka Tatenda Leopold
Published: March 2021

1989 CITES decision to put a total ban on international trade in ivory and the decisions to allow the 1999 and 2008 one-off-sales have generated polarized debates on whether or not these decisions are the reasons behind increasing levels of poaching in Africa. An undisputed fact is that; international illegal ivory trade has promoted rampant elephant poaching in Africa. What has and is contested is whether the ban or the one-off sales have a role to play in the current elephant poaching and increase in the illegal ivory trade. The Southern African range countries blame the international ivory trade ban for the current ivory poaching levels, while Countries such as Kenya, Benin and Uganda have blamed the sales for reigniting international appetite for ivory. The available evidence suggests that the international ivory trade ban with an unbanned domestic market has promoted poaching and negatively impacted on range countries’ ability to effectively and sustainably protect elephants. Besides the reduction or elimination of revenue, the ban undermined the economic incentives associated with elephant conservation, thereby making elephant conservation unattractive, unachievable and subsequently opening up to poaching and illegal trade.
RESISTANCE TO CHANGE MAHASISWA PSIKOLOGI UNIVERSITAS ESA UNGGUL YANG MENGIKUTI PERKULIAHAN ONLINE
Authors: Sulis Mariyanti
Published: March 2021

AbstrakDengan teknologi internet yang semakin canggih, beberapa institusi pendidikan termasuk Universitas Esa Unggul mulai menyesuaikan diri dengan mengembangkan pola pembelajaran online/daring yang dinilai lebih efektif dan efisien, tidak hanya bagi dosen tetapi juga bagi para mahasiswa. Perubahan pola pembelajaran dari yang konvensional dengan menggunakan tatap muka penuh berganti dengan pola pembelajaran yang menggunakan pembelajaran jarak jauh atau yang dikenal dengan pembelajaran online tampaknya menuai beragam respon maupun sikap dari para mahasiswa psikologi yang mengikuti materi kuliah online maksimal 3 materi kuliah online di setiap semester. Setiap perubahan akan diikuti oleh ketidaknyamanan sehingga ada yang bersikap tidak mendukung dan menolak perubahan atau dikenal dengan istilah resistance to change, namun ada pula mahasiswa yang merasa beruntung dengan diterapkannya perkuliahan online. Tujuan penelitian ini yaitu mengetahui profil resistance to change mahasiswa psikologi yang mengikuti perkuliahan online. Penelitian ini merupakan penelitian kuantitatif deskriptif dengan sampel 87 mahasiswa psikologi UEU yang pernah mengikuti perkuliahan tatap muka dan online minimum satu semester. Skala Resistance To Change (RTC) disusun berdasarkan acuan dari Oreg (2008) dengan 42 item valid dan nilai reliabilitas 0,97. Hasil penelitian menunjukkan lebih banyak mahasiswa psikologi yang rendah RTC nya (61%) atau lebih banyak yang menerima perubahan pola pembelajaran konvensional menjadi online. Mahasiswa yang rendah RTC nya adalah yang berstatus bekerja, belum menikah, berjenis kelamin laki-laki. Kata kunci: Resistance To Change, Pola Belajar Online, Mahasiswa Psikologi
Analisis Faktor Penentu Keinginan Pegawai untuk Berhenti Bekerja dan Iplikasinya pada Perbankan Syariah di Indonesia
Authors: Gumay Boby Rachman , Firdaus Achmad , Yasid Mukhamad
Published: March 2021

Penelitian ini bertujuan untuk menganalisa pengaruh lingkungan kerja, kompensasi dan religiusitas terhadap keinginan pegawai untuk berhenti bekerja pada perbankan syariah di Indonesia. Kuesioner diisi oleh 209 orang pegawai bank syariah di Indonesia dan data yang diperoleh diolah dengan metode Structural Equation Modeling (SEM) menggunakan software SmartPLS versi 3.2. Lingkungan kerja dan kompensasi berpengaruh negatif terhadap keinginan pegawai untuk berhenti bekerja. Religiusitas adalah satu-satunya variabel yang berpengaruh positif terhadap keinginan pegawai untuk berhenti bekerja dari perbankan syariah. Penelitian ini merupakan salah satu penelitian perintis di bidang personalia (HRD) yang membahas mengenai keinginan pegawai untuk berhenti bekerja dengan menggabungkan tiga variabel independen yakni lingkungan kerja, kompensasi dan religiusitas dengan sampel serta mencakup ± 50% entitas bank syariah yang ada di Indonesia. Penelitian ini diharapkan dapat memberikan manfaat bagi manajemen di perbankan syariah agar dapat mengambil langkah stratejik yang tepat di bidang kepegawaian terutama yang berkaitan dengan keinginan pegawai untuk berhenti bekerja sehingga dapat mengatasi tingkat keluarnya pegawai yang tinggi demi meningkatkan kinerja perbankan syariah di Indonesia secara umum di masa mendatang
The Impact of Organic Liquid Nitrogen Fertilizer Application on Growth and Productivity of Barley (Hordeum vulgare L.) Varieties
Authors: MUTLU Arzu , TAŞ Timuçin
Published: March 2021

Barley is a cereal used extensively in animal nutrition in the world. Nowadays, Organic practices have an important place in healthy nutrition of people and animals and protection of agricultural lands. This study was conducted to determine the effect of organic applications such as organic liquid nitrogen and barn manure on yield and quality values of barley during 2018-2019 and 2019-2020 growing seasons according to the randomized complete block design with split plot arrangements. This two-year study inferred the impact of organic liquid nitrogen fertilizer application at different growth stages on growth and productivity of barley. Organic liquid nitrogen fertilizer was applied at different phenological periods (control, tillering, beginning of booting, end of booting and heading) of spring barley varieties, Akhisar and Samyeli. Parameters such as Plant height (cm), number of heading (number m-2), hectoliter weight (kg hl-1), 1000 grain weight (g), grain yield (kg ha-1), chlorophyll content (SPAD values) and protein ratio (%) were determined in the study. All parameters investigated were significantly different (P≤0.01) between the years. Compared to the first year, higher temperature and drier weather conditions during the second year increased protein ratio in seed, while decreased starch ratio; thus, yield and yield components were lower. Yield and yield parameters of barley varieties had a negative correlation between protein ratios, while had a positive correlation with chlorophyll content. The results concluded organic liquid nitrogen application at the end of booting phenological period of Akhisar variety resulted in higher yield and improved the related traits. It has been concluded that the organic liquid fertilizer to be applied in this phenological period will increase both yield and quality in barley plants. Another result of this study was that as a result of organic applications, the yield and quality levels obtained from barley was close to conventional agriculture.
Systematic Mapping of Methodologies Used for the Validation of Models and Scales Derived From e-SQ
Authors:   Ph.D Student, Universidad Popular Autónoma Del Estado de Puebla (National Autonomous Popular University of Puebla) México., Olea-Flores Diana Faviola
Published: March 2021

Electronic Service Quality (e-SQ) is a topic that has been reviewed by several authors and, given the situation we live in, has become more relevant in the world; therefore, it is of vital importance to generate an effective measurement of the service being provided, which will allow companies to know the needs and expectations of their customers and how they evaluate the service received. This article considers an exploratory-descriptive research, which through a systematic literature mapping (MSL) reviews the methods and techniques that have been applied for the validity of the scales derived from e-SQ, thus generating a focused view of the methods applied in scientific research in the last five years. With the results obtained, a theoretical model for validating a scale is generated and proposed, which could be useful for researchers seeking to confirm and validate their scales or who are in the process of developing a research project.
Dynamics of Bangladeshi Politics: Business Interest, Conflict and Challenges in Governance
Authors:   Assistant Professor, Department of Government and Politics, Jahangirnagar University, Hasan Kamrul
Published: March 2021

Bangladesh is performing better in the growth of GDP and experiencing remarkable progress in development indicators such as poverty alleviation, maternal mortality, infant mortality and enrollment in primary education. However, despite the restoration parliamentary democracy in 1990s, political governance is decaying in the country. The present study, taking dynamics of Bangladeshi politics into consideration, seeks to explore the interplay between business and politics and its impact on governance with supplementary evidence from public transportation sector as case example. Among others, the principal question of the paper is how business interest creates crisis in governance? It reveals that business elites are involved in all decision-making process in the government institutions and they make pro-business policy undermining people’s interest that leads to a confrontation between government institution and business elites which ultimately generates crisis in governance in almost all other section of the nation like transportation sector.
SARS-CoV-2 Protease-Dependent Human Cell Infection Induces Immunological Response Imbalance and Neutrophils “Proteolytic Storm”. Proteolysis Inhibitors can Prevent and Treat Covid-19
Authors:   Regenhealthsolutions Research Unit, Bologna, Italy, Fornasari Pier Maria
Published: March 2021

Based on Chinese CDCP report on COVID-19, 14% of patients presented severe disease and 5% critical conditions. The average case-fatality rate was 2.3%, but mortality was as high as 49% in patients with critical illness. Serious life threatening thromboembolic complications have been found in 71•4% of non survivors and micro/macro angiopathic coagulopathy has been found, at autopsy also, with highly increased neutrophil number, fibrinogen, concentrations of D-dimer and FDPs and NETs, ATIII decrease and normal number of platelets. A cytokine storm and interaction between inflammation and coagulation has been advocated as explanation of hypercoagulability. It has been shown that SARS-CoV-2 infection of alveolar cells is driven by the S-protein by engaging ACE2 and TMPRSS2 cell receptors. whose activation depends on the activity of various host proteases. Full inhibition of SARS-CoV-2 entry was observed when serine proteases inhibitor camostat mesylate was coupled with Cathepsin B/L inhibitor E-64d. In addition multiple proteases are involved in host immune response against viral invasion and immunopathology related to imbalanced immune activation. In this paper it’s hypothesised that the severity of Covid-19 is induced by recruitment of innate responder neutrophils, which release proteases and NETs inducing endothelial damage and imbalance of the four major proteolytic cascades (coagulation, complement, fibrinolysis and kallikrein) with prevalence of activators over inhibitors and consequent thrombotic complications. Platelets adhesion to damaged endothelium and vWFVIII multimers presence, due to loss of ADAMTS13, contributes to hypercoagulability state. Human plasma or serine protease inhibitors like aprotinin can help to control neutrophil induced “proteolytic storm”. The goal of this paper is to support the view that, in SARS-CoV-2 infection, proteases have a key role and exceeding imbalanced neutrophil innate “unfriendly fire” response can be identified as the trigger of a “proteolytic storm”, responsible for subsequent well known hypercoagulation and “cytokine storm” and human plasma, in adequate volumes, together with serine proteases inhibitors can be an effective therapeutic strategy.
A oposição à revolução constitucional portuguesa em 1820 - Um “folheto” censurado de F. J. da Madre de Deus
Authors: Moreira Vital , Domingues José
Published: March 2021

Neste artigo analisamos um “panfleto” inédito da autoria de Justino José da Madre de Deus sobre a Revolução Liberal portuguesa, que se achou num arquivo brasileiro e que publicamos em anexo. O texto foi redigido em finais de setembro de 1820, tinha decorrido pouco mais de um mês desde o início da Revolução no Porto (24 de agosto). Embora defenda consistentemente a monarquia constitucional e esteja longe do fundamentalismo contra o constitucionalismo liberal que a partir de 1823 haveria de caracterizar a literatura política de Madre de Deus, neste escrito são, no entanto, já patentes as profundas divergências com o projeto constitucional revolucionário, o que lhe valeu a recusa de publicação por parte da Comissão de Censura liberal lisboeta.
La formación de los empleados públicos desde el punto de vista jurídico y organizacional. Dos perspectivas necesariamente entrelazadas
Authors: MOHAMED VÁZQUEZ Rashid
Published: March 2021

LABURPENA: Administrazio Publikoen zerbitzura lan egiten duten enplegatuen prestakuntza ikuspuntu juridikotik aztertu daiteke —langilearen eskubidea eta betebeharra den aldetik—, bai eta erakunde-ikuspegitik ere —erakundeko helburuen arabera prestakuntza ezartzeko modurik onena zehazteko ikuspegian oinarrituta—. Ikuspegi juridikoan, zehazki, prestakuntza jasotzeko betebeharra urratzeak dakartzan ondorioak aztertuko ditugu. Halaber, berariaz ikertuko dugu prestakuntzaren eta berdintasunerako eskubidearen arteko harremana, bai eta administrazioak interes orokorra lortzeko duen betebeharrarekiko lotura ere. Azken alderdi horrek, hain zuzen ere, erakunde-ikuspegiarekin egingo du bat. Horren barruan aztertuko ditugu, besteak beste, planifikazio estrategikoa aldez aurretik egiteko beharrizana, eta prestakuntza, ezagutza teknikoak eskuratzera ez ezik, beste era bateko eskumenak garatzera bideratzeko beharrizana; hori guztia, interes orokorra lortzen dela bermatzeko. RESUMEN: La formación de los empleados al servicio de las Administraciones Públicas puede analizarse desde un punto de vista jurídico —como derecho y deber del empleado— y desde una perspectiva organizacional —óptica basada en determinar el mejor modo de configurar la formación con arreglo a los objetivos de la organización—. Respecto a la perspectiva jurídica, estudiaremos las consecuencias del incumplimiento del deber de formarse, analizando igualmente la relación existente entre la formación y el derecho a la igualdad, así como su conexión con el deber administrativo de perseguir el interés general. Esto último enlazará con el punto de vista organizacional donde recogeremos, entre otros extremos, la necesidad de realizar una planificación estratégica de forma anticipada y de orientar la formación no solo a la adquisición de conocimientos de tipo técnico sino también al desarrollo de competencias de otra índole; todo ello como garantía para el logro del propio interés general. ABSTRACT: The training of Public Administration employees can be analyzed from a legal point of view —as a right and duty for the employee— or from an organizational perspective —from an optic based in determining the best way to configure the training in accordance with the objectives of the organization—. With regard to the legal perspective, we will study the consequences of infringement of the duty of training, also examining the relationship between training and right to equality, together with its connection to the administrative duty to pursue the general interest. This latter will link with the organizational point of view where we will reveal, amongst other things, the need for establishing an anticipated strategic planning and for targeting the training not only to to acquire technical knowledge but also to develop competences of a different type; all as a guarantee for achieving the general interest.
LOS INSTRUMENTOS DE CONTROL DEMOCRÁTICO Y DE RENDICIÓN DE CUENTAS EN EL GOBIERNO DE LA UNIÓN ECONÓMICA Y MONETARIA
Authors: HUICI SANCHO LAURA
Published: March 2021

La deficiencia en los mecanismos de control democrático y rendición
de cuentas en el funcionamiento de la Unión Europea ha sido ampliamente
debatida por la doctrina. Aunque, con carácter general, existen posturas divergentes
al respecto, cuando el debate se circunscribe al ámbito de la UEM, el consenso
es mayor. Y ello porque, en particular, como reacción a la crisis de la deuda soberana,
en esta materia, se han priorizado vías de acción ad hoc, eminentemente de
naturaleza intergubernamental y ajenas al método comunitario. La complejidad
abunda en la falta de transparencia en el funcionamiento de las instituciones, estructuras
y representantes de los Estados en este ámbito. Con todo, la difícil vuelta
a la «normalidad» en la zona euro parece convertirse, con el paso del tiempo, en
aliada al objetivo de establecer una verdadera política económica europea. Si ello
sirve para simplificar el funcionamiento y aclarar el papel de las distintas instituciones
responsables, se mejorará la calidad del control democrático y la rendición
de cuentas

Doktrinak sarri eta sakon aztertu du kontrol demokratikoa eramateko
eta kontu emateko mekanismoen eskasia Europar Batasunaren jardunean.
Orokorrean, kontu horren inguruan kontrako jarrerak dauden arren, eztabaida Europako
Ekonomia eta Diru Batasunaren alorrera murrizten denean, adostasuna
handiagoa da. Zehazki, zor subiranoaren krisiak ekarritako erreakzioa dela-eta,
kontu hauetan ad hoc ekintzei (gobernuen artekoei nagusiki) lehentasuna eman
zaielako, metodo komunitariotik erabat apartekoak izan arren. Erakunde, egitura
eta estatuen ordezkarien funtzionamenduan oraindik ere gardentasun gutxiago
egotea eragiten du konplexutasunak. Nolanahi ere, euro eremuan atzera ere «normaltasuna
» bueltatzea zaila bada ere, badirudi, denbora pasa ahala, normaltasun
hori lagungarri izango dela benetako politika ekonomiko europarra taxutzeko. Funtzionamendua
sinplifikatzeko eta ardura daukaten erakundeen papera argitzeko
balio badu, kontrol demokratikoaren eta kontu ematearen kalitatea hobetzeko ere
balioko du.

The deficiency of the mechanisms of democratic control and
accountability in the functioning of the EU has been widely discussed by the
doctrine. Although, in general, there are conflicting opinions, consensus is greater
when the debate is limited to the field of the EMU. That is particularly because as
a reaction to the sovereign debt, ad hoc actions have been prioritised in this area,
eminently those of intergovernmental nature and outside the Community method.
The complexity abounds with the lack of transparency of the functioning of the
institutions, structures and representatives in this field. However, the difficult
return to «normality» within the euro zone seems to become over time in an ally to the objective of establishing a true European economic policy. If that works so
as to simplify the functioning and to clarify the role of the responsible different
institutions, the quality of the democratic control and accountability will be
improved.
Levenskwaliteit een jaar na radiofrequente ablatie van de vena saphena magna
Authors: Craeghs L. , Bechter-Hugl B. , Thomas S. , Fourneau I.
Published: March 2021

Symptomatische varices hebben een negatieve invloed op de levenskwaliteit van patiënten. Radiofrequente ablatie (RFA) is een endoveneuze behandelingsmethode waarbij varices worden dichtgeschroeid. Het doel van deze studie is om de tevredenheid en de patiënt-gerapporteerde levenskwaliteit te onderzoeken meer dan een jaar na RFA van de vena saphena magna (VSM). Een vragenlijst werd gestuurd naar 200 patiënten die een tot twee jaar geleden behandeld werden met RFA van de VSM in UZ Leuven. De gegevens werden verwerkt in SPSS Statistics 24. 98 van de 200 patiënten (49%) namen deel aan de studie. Van de patiënten was 80,4% (78/97) tevreden en zou 95,8% (92/96) opnieuw voor RFA kiezen. Het zelfbeeld was bij 58,2% (57/98) beter en de algemene gezondheid was bij 29,6% (29/98) beter dan voor de ingreep. Meer dan een jaar na de ingreep had 57,4% (54/94) geen recidieven of nieuwe varices. Ontevredenheid was frequenter bij patiënten met een flebologische voorgeschiedenis, bij patiënten met recidieven of veneuze symptomen en bij patiënten met een postoperatief hematoom. RFA van de VSM leidt tot tevredenheid bij patiënten die deelnamen aan deze studie en heeft een positieve invloed op het zelfbeeld en op de ziektegerelateerde symptomen meer dan een jaar na de ingreep.
Obsessieve-compulsieve stoornis: praktische handvatten voor de huisarts
Authors: TANDT H. , AUDENAERT K. , LEMMENS G.
Published: March 2021

Obsessive-compulsive disorder: practical tools for the GP

Obsessive-compulsive disorder (OCD) is a relatively prevalent complex psychiatric disorder associated with significant impairment and distress. OCD remains often undetected because of the reluctance of patients to discuss their symptoms and the lack of recognizing OCD symptoms by the physicians.

The general practitioner (GP) should be able to recognize OCD symptoms since a chronic course is associated with poor prognosis. The GP has a key role to play in the recognition, diagnosis, treatment and referral of patients with OCD. An early detection in all patients at higher risk of OCD provides timely access to evidence-based therapies. Psychoeducation about the disorder is an important step for improving recovery. Treatment of choice is cognitive behavioral therapy with exposure and response prevention combined with or without a selective serotonin reuptake inhibitor (SSRI). The required medication doses are often higher and duration to response longer than those for depression. In- and exclusion criteria for deep brain stimulation (DBS) are carefully defined in Belgium by the committee peer review OCD for therapy refractory OCD. The GP has also a critical role in the follow-up of patients with OCD over time by monitoring the relapse risk, therapy compliance and side effects of the medication.
Gezondheidsgegevens als nieuw zakenmodel
Authors: PELEMAN R. , VAN BIESEN W. , DECRUYENAERE J. , STERCKX S.
Published: March 2021

Bedrijven kunnen medische gegevens halen uit verschillende bronnen: Facebook-berichten, aankopen met kredietkaart, inhoud van e-mails of recent bekeken video’s op YouTube. In principe houden deze gegevens geen verband met de gezondheidstoestand van de gebruiker. Kunstmatige intelligentie-instrumenten en “big data”-algoritmen kunnen betekenisloze informatie evenwel omzetten in gevoelige medische gegevens. Deze “emergent medical data” of “onverwachte medische gegevens” bieden mogelijke voordelen, zoals de opvolging van de verspreiding van een besmettelijke ziekte, de identificatie van mensen met een risico op suïcide of moord en drugmisbruik. De belangrijkste aantrekkingskracht voor organisaties van de toenemende beschikbaarheid van medische gegevens is de mogelijkheid tot gedragsgerichte “targeting” (ook “nudging” genoemd) en de optimalisatie van de klantprofilering en de marketing. Vaak gebeurt dit zonder expliciete instemming van de eigenaar van de gegevens. Algoritmen ontwikkeld op basis van niet-gevalideerde medische gegevens kunnen leiden tot minder nauwkeurige diagnostische en/of voorspellende instrumenten. Gebruikers moeten beseffen dat medisch relevante gegevens kunnen worden afgeleid van hun internetactiviteit. Bijzonder privacygevoelige persoonlijke gegevens komen in een grote gecentraliseerde databank terecht. Op het moment dat de “onverwachte medische gegevens” worden gegenereerd, moet de gegevensverwerker de gebruiker waarschuwen. Een opt-outverzoek moet mogelijk zijn. De op deze manier verzamelde informatie is niet beschermd door de “Algemene Verordening Gegevensbescherming” (AVG), ook gekend als de “General Data Protection Regulation” (GDPR). Deze wet trad in werking in mei 2018. De implementatie ervan verloopt moeizaam, waardoor de privacy en het zelfbeschikkingsrecht van de gebruiker onder druk komen te staan.
Lupus mastitis
Authors: WILLERS N. , BERTELOOT P. , WITTEVRONGHEL I. , JACOMEN G. , SCHELFHOUT V. , VANWAMBEKE K.
Published: March 2021

Lupus mastitis

Systemic lupus erythematosus (SLE) infrequently presents itself as lupus panniculitis. In lupus panniculitis the subcutaneous fat tissue is involved in the inflammatory process. Lupus mastitis is again a rare variant of lupus panniculitis, probably caused by an immune-mediated inflammatory process.

In literature on the topic we can find 30 cases of lupus mastitis in men and women. Lupus mastitis may present like a breast lesion suspected to be malignant, clinically and radiologically.

In the differential diagnosis we consider inflammatory breast cancer, subcutaneous panniculitis-like T-cell lymphoma (SPTL) and diabetes mastopathy. With a medical history of SLE and signs of inflammation of the skin above the lesion however, a diagnosis of lupus mastopathy is more presumable.

Medical treatment seems more indicated in lupus mastitis, because delayed healing after surgical procedures is often reported. Even though methylprednisolone and chloroquine give clinical improvement, they need to be repeated often because of a high risk of relapse.
De behandeling van perifere spondyloartritis in 2020
Authors: CARRON P. , DE CRAEMER A. , VAN DEN BOSCH F.
Published: March 2021

De behandeling van perifere spondyloartritis (pSpA) is zeer uitdagend omwille van een vaak heterogene presentatie van alle mogelijke symptomen in combinatie met een beperkt aantal terugbetaalde medicamenteuze therapieën.

Het klinisch denken is op heden georiënteerd op een globale diagnose van spondyloartritis (SpA) waarbij axiale dan wel perifere symptomatologie op de voorgrond staat. Het belangrijkste voordeel van die aanpak, die geïnspireerd werd op de meest recente ASAS (Assessment of SpondyloArthritis International Society) classificatiecriteria, is het herkennen en behandelen van alle SpA-subtypes in een vroegtijdig stadium.

Het belang daarvan kan niet onderschat worden. Enerzijds resulteert het vroegtijdig opstarten van een adequate behandeling in een betere therapierespons op korte termijn, waarbij zelfs medicatievrije remissie tot de mogelijkheden behoort. Anderzijds worden betere langetermijnuitkomsten bereikt bij het vroegtijdig instellen van therapie: structurele gewrichtsschade en bijhorende functionele beperkingen worden grotendeels vermeden.

Dit artikel bespreekt de huidige behandelingsopties en -strategieën in perifere spondyloartritis.
Neuropsychologische problemen na focale laesies in het cerebellum: de kleine hersenen worden groot
Authors: BEECKMANS K. , MICHIELS K.
Published: March 2021

Neuropsychological problems after focal lesions in the cerebellum: the little brain grows big

Initially researchers believed that the cerebellum was only involved in motor and speech functions. During the last few years however, increasing knowledge was gained regarding the neuropsychological functions of the cerebellum. These functions are not exclusively considered as being regulated by cortical brain structures, but rather as functions regulated by a closed cerebro-cerebellar circuit.

Studies focused on evaluating neuropsychological functioning in patients with focal lesions in the cerebellum have discovered that cognitive problems with regard to working memory, anterograde memory, visuospatial functions, language and executive functions are frequently documented.

Besides cognitive deficits, these patients can also show emotional and/or behavioral changes. Several authors assume that the research findings concerning memory, visuospatial functions and more particularly language can be explained by the concept of crossed cerebellar-cerebral diaschisis.
Vallecula-cyste: een zeldzame oorzaak van progressief toenemende inspiratoire stridor bij een neonaat
Authors: MONBAILLIU E. , SCHELSTRAETE P. , BONTE K. , VERCRUYSSE T.
Published: March 2021

Vallecular cyst: a rare cause of progressive inspiratory stridor in a neonate

The medical history of an infant with progressive inspiratory stridor caused by a vallecular cyst is presented. The cyst was diagnosed via a laryngoscopy and treated by means of an excision. The postoperative course was complicated by severe stridor induced by post-intubation edema. This report elaborates on the clinical presentation and work-up.

The differential diagnosis of neonatal stridor is exhaustive. A congenital vallecular mass rarely causes it. These masses can manifest in various ways. Symptoms usually develop during the first week(s) of life. Key symptoms are upper airway obstruction and feeding difficulties. Life threatening situations are also possible. Given that the exact etiology of vallecular cysts remains unclear, different hypotheses were proposed. The differential diagnosis should include a dermoid cyst, a thyroglossal duct cyst, a teratoma, an hemangioma or lingual thyroid. The diagnosis usually requires a flexible and/or direct laryngoscopy. Radiographic imaging may also contribute to the work-up, adding information about the anatomical dimensions (for example with regard to the surrounding structures), the exact location, the magnitude, the content, etc. The definitive diagnosis is made through pathological evaluation. Different treatment options are proposed, preferably endoscopic excision or marsupialization.