bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics of forest honey from several areas in Riau Province, Indonesia
Authors: Desfita Sri , Sari Wulan , Yusmarini Yusmarini , Pato Usman , Budryn Grażyna
Published: December 2022

Honey quality is influenced by several factors, including transportation conditions and length of storage. This study aimed to investigate the composition, characteristics, and quality of honey from several regions in Riau and Riau honey sent to Java Island. Honey samples were obtained from five districts in Riau Province, namely, Inderagiri Hulu, Kuantan Singingi, Pelalawan, Bengkalis, and Kampar Regencies. The honey parameters observed were based on the Indonesia National Standard (SNI) of honey. Data were analyzed descriptively by comparing the characteristics of honey samples from Riau Province. Results showed a significant difference between honey sent and those not sent between islands. Significant differences were mainly observed in hydroxymethylfurfural (HMF) levels. Almost all honey samples sent to Java Island had HMF levels above 50 mg/kg. Meanwhile, all Riau honey samples from the five regions had HMF levels below 50 mg/kg. The diastase enzyme activity was slightly higher in the honey samples from the five regions. Land transportation to the island decreased the quality of honey as indicated by the high levels of HMF and decreased diastase enzyme activity. Therefore, mileage and storage conditions must be considered in the delivery of Riau honey to other regions.
Simulación de esfuerzos en diseño digital de ortesis lumbar
Authors: Pérez Guadián Juan Ismael , Meraz Tena Erika Guadalupe , Estrada Meneses Edson Francisco
Published: December 2022

Al analizar los distintos métodos para tratar una lesión lumbar, el tratamiento por medio de antiinflamatorios y opioides, así como el uso de exoesqueletos en el más avanzado de los casos, se observa que no existen muchos dispositivos que se puedan utilizar para la prevención de estas y que las ortesis actuales están enfocadas a tratar el dolor o bien a ofrecer algún tipo de rehabilitación. La presente investigación tiene como finalidad ofrecer un análisis de los esfuerzos lumbares que ayude en el diseño de ortesis de soporte lumbar como una alternativa para prevenir lesiones en trabajadores del área de la enfermería, en la que existe un alto índice de lesiones de tronco y raquis por la naturaleza del trabajo en el que se tiene que mover pacientes inmóviles varias veces al día. Por medio de la simulación de un modelo antropométrico y la programación de musculatura independiente en el software OpenSim, se obtuvieron datos de esfuerzos máximos que pudieran ser utilizados para el diseño de ortesis de soporte lumbar, con beneficios como la rapidez para obtenerlos, no tener que utilizar equipo de análisis físico costoso ni tener que intervenir sujetos de prueba.
Implementación de la metodología Lean Sigma en un proceso de ensamble de engranes y cadenas: Caso de estudio
Authors: Celis Gracia Omar , Toscano Moctezuma Juan Alfonso
Published: December 2022

La metodología orientada a solución de problemas propuesta en este artículo de investigación tiene como objetivo actuar a la velocidad de Lean brindando resultados en al menos cuatro semanas. Las cinco fases de esta metodología son: identificar y medir el problema; encontrar las posibles causas que están generándolo; desarrollar una solución empleando herramientas de Lean o de Seis Sigma; una vez implementada la solución, verificarla con una corrida de comprobación y, finalmente, desarrollar un plan de control para asegurar que el estado alcanzado se mantenga en el mediano y largo plazos. Para comprobar la efectividad de la metodología Lean Sigma, se presenta un caso de aplicación en un proceso que no cumple con los requerimientos de entrega a tiempo. Por medio de herramientas Lean, como rebalanceo de la línea, takt time y just in time, se logró incrementar el porcentaje de entregas a tiempo de un 66 % a un 100 % y, a su vez, la productividad aumentó de 1.8 a 2.5 piezas/min*hombre y el lead time disminuyó de 26.07 a 17 segundos, equivalente a una mejora del 35 %. El problema fue resuelto en 24 días y la capacidad del proceso fue de un 2.6 a 3.4 sigma.
Satisfacción laboral de personas con discapacidad motriz por la tendencia postural
Authors: Velázquez Macías Adolfo , Maldonado Azpeitia Luis Fernando , García Pitol Jorge Arturo , Rodríguez Reséndiz Juvenal
Published: December 2022

El presente documento representa un extracto de una investigación acerca de la perspectiva de la satisfacción laboral de las personas con discapacidad motriz que laboran en una jornada continua en México, con relación a su tendencia postural. Para ello, se llevó a cabo un estudio descriptivo de corte transversal en el que se administró el instrumento denominado Cuestionario de Satisfacción por Factores Ergonómicos para Trabajo en Postura Sedente que, por la pandemia COVID-19, se aplicó a un grupo de 15 personas que comparten características laborales similares a trabajadores con discapacidad motriz, con el objetivo de obtener información acerca de la disciplina postural y condiciones de salud laboral. Los resultados de este instrumento mostraron la satisfacción moderada de los participantes, pues consideran que la carga postural y de trabajo generan fatiga. Asimismo, expresaron su disposición por integrar estrategias de rehabilitación postural que puedan servir para la construcción de un dispositivo que obtenga y comunique la medición del tronco del usuario cuando pierda su simetría y ortogonalidad en una interfaz gráfica. El estudio concluye con la configuración de un panorama de la realidad laboral de las personas con discapacidad motriz que permite comprender el comportamiento postural y la temporalidad que estos perpetúan en la rectitud de su postura.
Ignaz Goldziher’in Hadis Edebiyatı ve Kavramlarına Yaklaşımları
Authors: KILIÇ Bilge
Published: December 2022

Hz. Peygamber’in risaleti boyunca temsil ettiği ve örneklediği İslâm dininin iki tezahür biçimi vardır. Bunlardan biri onun mübarek sözleri ‘Hadis’ iken, diğeri de fiili uygulamaları olan ‘Sünnet’tir. ‘Sünnet’ doğal olarak ümmetin onları aynen taklit edip devam ettirmesiyle varlığını sürdürmüş, ‘Hadis’ ise kısmen yazı ile büyük ölçüde de hafızanın yardımıyla ezberlenerek korunmuş ve sonraki nesillere aktarılmıştır. Yazılı olarak muhafaza edilen hadisler zamanla tedvin ve tasnif edilmiş, bunun sonucunda Musannef, Muvatta, Câmi‘, Sünen ve Müsned gibi isimlerle anılan Hadis edebiyatı ortaya çıkmıştır. Hadis edebiyatının oluşumu ve gelişimi batılı araştırmacıların çalışmalarına konu edilmiştir. Oryantalistler, kendi perpektifleriyle Hadis edebiyatına ve kavramlarına ilişkin doğrudan veya dolaylı olarak bir takım değerlendirmelerde bulunmuşlardır. Özellikle Ignaz Goldziher (1850-1921), Hadis edebiyatının evrelerini bir çok açıdan ele almış, hadis kaynaklarını ve kavramlarını geniş bir şekilde mütaala etmiştir.
Bu makalede, Goldziher’in “Muhammedanische Studien” isimli eseri özelinde hadislerin yazıyla kaydı, tedvini ve tasnif süreci ile ilgili yaklaşımı ele alınacaktır.
Implementasi Green Economy pada Sistem Instalasi Pengolahan Air Limbah Tahu dan Sensor Terintegrasi di Kediri
Authors: Srikalimah  , Shobirin Rizky Arief , Shalahuddin Yanu , Mubarok Muhammad Syahrul , Pinandhita Aqli Supremadi Naufal
Published: December 2022

Every industry has special attention to environmental preservation; however, it has become an unresolved problem in the industrial center of tofu village. Based on the analysis, there were problems related to liquid waste produced by tofu craftsmen that doesn’t meet the Quality Standards for liquid waste of the Food Products Industry, limited costs, land, and space thus that it didn’t meet the adequacy of space for Wastewater Treatment Plants (WWTP). The PKM (Community Service Program) activity aimed to implement Green Economy Concept on Integrated WWTP Systems and Sensors for the Kediri Tofu Industry as an effort to solve the waste problem in the tofu industry. This activity began with field observations, compatibility and requirements analysis, construction design and designing WWTP systems and sensors, small-scale trials, analysis, and evaluation. The WWTP system used involves components of pre-treatment, neutralization, coagulation and flotation, sedimentation, and filtration. The designed sensors included Arduino Nano-based pH meter and TDS meter sensors that were connected to computers and smartphones by Arduino IDE and Blynk software. It was hoped that this activity might spur business actors to actively participate in solving waste problems and reducing environmental impact pollution with all the space and cost limitations.
OPBL Learning Model on Problem Solving Ability in Basic Programming Subjects in Vocational High Schools
Authors: Andhita Krisna , Untari Rahmania Sri
Published: December 2022

Basic Programming subjects are compulsory subjects at SMK 1 Walisongo, especially for the Multimedia major. The purpose of this study is to improve students' problem solving abilities. The research model used is experimental quantitative. The results showed that there was an effect between the pre-test using the problem based learning model with average 76,95 and the post-test using the open problem based learning with average 87,80 that occurred in class X MM as many as 20 students. Teachers pose problems and students solve problems based on their understanding of analysis, with students being given the freedom to present their own arguments through questions about basic programming topics. With the increasing value of learning, open problem-based learning model learning is the right learning model for teachers.
Characterization of Lord Cutler Beckett's Antagonist Character, Played by the Main Character, Tom Hollander in Pirates of the Caribbean: The Curse of the Blackpearl
Authors: Bestari Errina Candra , Novita Dian
Published: December 2022

The object of the study is Pirates of the Carribean‘s Movie series 1. The data of the study are in the form of explicit sentences and written dialogues . the data of this study are collected by doing the following steps: watching movie carefully for many times, identifying the data related to antagonist character, inventorizing the data, classifying the data, simplifying the data . selecting the data , and at last reporting the data into appendixes . there are several techniques to analyze the data . they are exposing , explaining , interpreting , and the last one is summarizing. the interpretation and the explanation are done from the point of view of sociological approach . The result of this study shows that there are many antagonist conflicts among the characters. the diiferent characters arise cause of individual and selfish societal aspects . Besides, the antagonist character is also found many sectors and has bad effects toward the third social class such as intimidation, physical attack , avoidance between first class toward to third class , and the last extermination. The third class is someone at low caste of social class that always received many kind of humiliation and never get a respect by the highest class of social. Therefore, they give some reactions towards first class who practice antagonist character to the third class such as submission, avoidance, and integration. Finally this study is expected to give more knowledge and understanding about Antagonist character in the real life between the first class among our society.
Problem Based Learning (PBL) Model on Students' Environmental Literacy Ability in Elementary School Natural Science Lessons
Authors: Ilma Mukhibatul , Wulandari Fitria Eka
Published: December 2022

This study aims to analyze the influence of problem based learning (PBL) models on students' environmental literacy skills in elementary science lessons.This study uses a pre-experimental quantitative research with a one-group pretest posttest design. The population in this study were all students of class V SDN Watukosek totaling 21 students. Samples were taken using saturated sampling with a sample of 21 students in class V SDN Watukosek. Data collection techniques used in the form of tests. Where this test is carried out before learning (pretest) and after learning (posttest). Where this test is carried out before learning (pretest) and after learning (posttest). The instrument used in this research is a matter of environmental literacy indicators. The analysis used is calculated using the N-Gain formula with the average pretest and posttest values of 56.38 and 81.26 while the N-Gain score is 0.56 in the medium category. Based on the results of this study, it can be concluded that the PBL model has an effect on students' environmental literacy skills in elementary science lessons.
Development of Ecologization of Tourism: Experience of Foreign Countries
Authors: Umirov Jasur Temirkulovich
Published: December 2022

The article considers the experience of countries that have significant natural potential and pursue an active policy for planning, regulating, supporting, promoting and monitoring ecotourism. The methods of formal-logical, comparative and institutional analysis were used during the research. It is shown that the experience accumulated by different countries in the development of ecotourism testifies both to the specifics of each of the countries and to general approaches harmonized with international recommendations and tasks to create conditions for sustainable development of tourism. Systematic approaches and innovative solutions that exist in different countries can be recommended in the “right decision” format, as they demonstrate how ecotourism can contribute to the achievement of sustainable development goals
The Effect of Accounting Understanding and Sak Etap Implementation on the Quality of MSME Financial Reports in Sidoarjo Regency
Authors: Khasanah Uswatun , Nurasik Nurasik
Published: December 2022

The purpose of this study was to determine the effect of accounting understanding on the quality of financial statements and the effect of the implementation of SAK ETAP on the quality of financial statements. The approach used in this research is a quantitative approach. This research was carried out in all MSMEs that were sampled and who had domiciles in the Sidoarjo Regency area. Researchers will directly go to MSMEs that meet the criteria as samples in this study to distribute questionnaires and after a specified period of time, researchers will return and take questionnaires. The analysis technique uses multiple linear regression analysis and hypothesis testing. In collecting data using a questionnaire. Based on the results of the study, it was proven that accounting understanding had a positive effect on the quality of financial statements, tested using the t-test, the results of the tcount value of the accounting understanding variable (X1) were 4.854 with a significance value of 0.000 so (0.000 <0.05). Then the implementation of SAK ETAP has a positive effect on the quality of financial reports, it is known that the t-count value of the SAK ETAP implementation variable (X2) is 15.678 with a significance value of 0.000 so (0.000 <0.05).
The Effect of Life Style, Self Control and Financial Literacy on Financial Management with Consumptive Behavior as A Moderating Variable
Authors: Lisdiana Dela , Setiyono Wisnu Panggah
Published: December 2022

This study aims to examine the effect of Life Style, Self Control and Financial Literacy on financial management with consumptive behavior as a moderating variable, a study of students at Muhammadiyah University of Sidoarjo. This research design is quantitative associative. The sample in this study used random sampling with a of 96 students from the University of Muhamadiyah Sidoarjo. The data used in this study is primary data taken by distributing questionnaires. The data analysis used in this study is SmartPLS with the aim of testing Life Style (X1), Self Control (X2), Financial Literacy (X3) on Financial Management (Y) with Consumptive Behavior (Z) as a moderating variable.The results of this study that Life Style, Self Control and Financial Literacy had a significant effect on financial management. While the Consumptive Behavior variable is able to moderate Self Control on Financial Management, the Consumptive Behavior variable is not able to moderate Life Style and Financial Literacy on Financial Management.
The Effect of Financial Literacy, Lifestyle and Personal Income on Consumptive Behavior in Millennial Generation in the Pandemic Era
Authors: Kiswoyo Ayu Rahmawati , Kumalasari Herlinda Maya
Published: December 2022

This study aims to describe and find out about the influence of Financial Literacy, Life Style and Personal Income on Consumptive Behavior in Millennial Generation In The Pandemic Era. This research method is a type of quantitative research with hypothesis testing. The sample used was 210 students from the 2018 batch at Muhammadiyah University of Sidoarjo. The data collection technique was carried out using a questionnaire distributed online using a google form. The data analysis technique in this study used multiple linear regression through the SPSS Statistics version 24 program. The results of this study indicate that, Financial Literacy has an effect on Consumptive Behavior, Life Style has an effect on Consumptive Behavior, Personal Income has an effect on Consumptive Behavior and Financial Literacy, Life Style and Personal Income have a simultaneous effect on Consumptive Behavior.
The Effect of Business Risk and Dividend Policy on Financial Performance with Capital Structure as an Intervening Variable
Authors: Wiguna Rr Hentia Endang Rahayu , Sriyono Sriyono
Published: December 2022

This study aims to determine the effect of business risk and dividend policy on financial performance with capital structure as an intervening variable. This study uses quantitative methods with secondary data as a data source. In this study the population data used are all pharmaceutical companies listed on the Indonesia Stock Exchange. The observation period was from the 2014-2020 period. In this study, non-probability sampling technique used in this study is purposive sampling. There are 8 pharmaceutical companies used as samples in this study. The data analysis technique used in this research is Structural Equation Modeling Partial Least Square (SEM-PLS). The results of this study indicate that business risk has an effect on financial performance. Dividend Policy Affects Financial Performance. Business risk Affects Capital Structure. Dividend Policy Affects Capital Structure. Capital Structure Affects Financial Performance. Capital Structure Mediates the Impact of Business Risk on Financial Performance. Capital Structure Mediates the Effect of Dividend Policy on Financial Performance
José Marchena en defensa de la libre sexualidad humana: el «Fragmento de Petronio» (1800)
Authors: Muñoz de Morales Galiana Javier
Published: December 2022

La literatura española del XVIII tomó como referente fundamental la de la antigüedad grecorromana, lo que también pudo repercutir en el género de la novela, en el que José Marchena llevó a cabo una falsificación de Petronio con el título de Fragmentum petronii (1800). Pero la moral epicúrea contenida en el Satiricón, surgida en un contexto pagano, nada tenía que ver con los preceptos católicos de la España de entonces. El presente artículo pretende analizar cómo la literatura latina sirve de base para que Marchena lleve a cabo, en su obra, una apología implícita de la libertad sexual humana. Para poder precisar esto último, se ha contextualizado al autor en el movimiento filosófico conocido como Ilustración radical, caracterizado por el ateísmo y la actitud transgresora, rasgos estos dos últimos que se han considerado, tras nuestro análisis, como imprescindibles para la composición de un texto tan inclinado al progreso.
Procesos robóticos para automatizar el procedimiento de asignación de órdenes y pedidos en áreas logísticas
Authors:   , Alarcon Ayquipa Ester
Published: December 2022

Los RPA o también conocidos como procesos robóticos son parte de la rama de inteligencia artificial (IA), se utilizan para la automatización de tareas o acciones realizadas por usuarios las cuales se copian por medio de algoritmos, y se ejecutan sin intervención del usuario. Para esta investigación el objetivo principal fue aplicar los procesos robóticos (RPA) para automatizar el procedimiento de asignación de órdenes y pedidos en el área logística de Dinet S.A Lima. Esta se basó en un diseño pre-experimental con un enfoque cuantitativo y por ser de tipo Aplicado se valió de reportes semanales de la asignación de órdenes y pedidos los cuales tomó como población la productividad diaria desde el 01 de diciembre 2020 al 31 noviembre 2021 y como muestra para un análisis inicial de pre-test se abarco desde el 15 de agosto del 2021 al 16 de setiembre del 2021 y para el pos-test desde el 15 de octubre del 2021 al 16 de noviembre del 2021. Un rango total de 60 días. Donde se aplicó la validez y confiabilidad. Asimismo se recurrió a métodos estadísticos para comprobar la hipótesis con Wilcoxon y la T, donde los resultados mostraron un nivel de significancia igual a 0,000 siendo menor al 0.05 para la variable dependiente y en sus dimensiones donde se demostró que la aplicación de procesos robóticos (RPA) mejora el procedimiento de asignación de órdenes y pedidos en el área logística de Dinet S.A Lima.
Percepción estética del arco de la sonrisa entre alumnos de Odontología, artistas y laicos, Lima 2020
Authors:   , Segura Cobeña Melissa Iveth
Published: December 2022

Objetivo: En la presente investigación se propuso comparar la percepción estética del arco de la sonrisa entre alumnos de odontología, artistas y laicos, Lima 2020. Material y métodos: Se mostraron tres tipos de arco de sonrisa: convexo, cóncavo y recto, los cuales fueron analizados por los encuestados. El instrumento de evaluación fue la Escala Visual Análoga, del 0 al 50 poco atractivo y del 51 al 100 muy atractivo. La muestra total fue 210 estudiantes (70 por grupo). Para el análisis estadístico se utilizó la prueba de ANOVA, la prueba post-hoc de Tukey y la prueba T de Sstudent. Resultados: No se encontró diferencias de percepción estética entre los tres grupos, pero todos los grupos señalaron al arco convexo como muy atractivo y al arco cóncavo como poco atractivo. Sin embargo sí se observaron diferencias significativas en el grado de aceptabilidad del arco de la sonrisa en cada grupo. No se encontró relación entre el sexo y la percepción estética del arco de la sonrisa, con excepción de estudiantes mujeres odontólogas quienes percibieron como poco atractivo al arco recto, que los estudiantes hombres odontólogos. Conclusión: La percepción estética no difiere entre alumnos de odontología, artistas y laicos, sin embargo los estudiantes de odontología suelen ser más críticos al analizar los tipos de arco de la sonrisa.
Novel solutions of the generalized mixed nonlinear Schrodinger equation with non-zero boundary condition
Authors: Qiu Deqin , Zhang Yongshuai
Published: December 2022

We present a determinant representation of generalized Darboux transformation for a generalized mixed nonlinear Schrodinger equation, and obtain several novel solutions with non-zero boundary condition. A complete classification of first–order solution with non-zero boundary condition is considered, and several second–order solutions, including some interesting structures, are discussed. Furthermore, by selecting special parameters in the equation, several novel kinds of solutions for the equation are displayed. Finally, we discuss the effects of parameter β , representing quintic nonlinearity term, on the breather solutions.
Risk of drug use during pregnancy: master protocol for living systematic reviews and meta-analyses performed in the metaPreg project
Authors: Picot Cyndie , Ajiji Priscilla , Jurek Lucie , Nourredine Mikail , Massardier Jérôme , Peron Audrey , Cucherat Michel , Cottin Judith
Published: December 2022

Background Knowledge about the risks of drugs during pregnancy are continuously evolving due to the frequent publication of a large number of epidemiological studies. Systematic reviews and meta-analyses therefore need to be regularly updated to reflect these advances. To improve dissemination of this updated information we developed an initiative of real time full-scale living meta-analyses relying on an open online dissemination platform ( www.metapreg.org ).
Method All living meta-analysis performed in this project will be conducted in accordance with this master protocol after adaptation of the search strategy. A systematic literature search of Pubmed and Embase will be performed. All analytical studies (e.g., cohort, case control, randomized studies) reporting original empirical findings on the association between in-utero exposure to drugs and adverse pregnancy outcomes will be included. Study screening and data extraction will be performed in a semi-automation way supervised by a biocurator. Risk of bias will be assessed using the ROBINS-I tools. All clinically relevant pregnancy adverse outcomes (malformations, stillbirths, neuro-developmental disorders, pre-eclampsia, etc.) available in the included studies will be pooled through random-effects meta-analysis. Heterogeneity will be evaluated by I2 statistics.
Discussion Our living systematic reviews and subsequent updates will inform the medical, regulatory and health policy communities as the news results evolve to guide decisions on the proper use of drugs during the pregnancy.
Systematic review registration Open science framework (OSF) Registries ( https://osf.io/u4gva )
Enhancing ferromagnetic coupling in CrXY (X = O, S, Se; Y = Cl, Br, I) monolayers by turning the covalent character of Cr-X bonds
Authors: Zhu Haoran , Shao Bin , Zuo Xu
Published: December 2022

On the basis of first-principles calculations, we investigate the electronic and magnetic properties of 1T phase chromium sulfide halide CrXY (X = O, S, Se; Y = Cl, Br, I) monolayers in CrCl2 structure with the P3m1 space group. Except for the CrOI monolayer, all CrXY monolayers are stable and ferromagnetic semiconductors. Our results show that the ferromagnetic coupling is dominated by the kinetic exchange between the empty eg-orbital of Cr atoms and the p-orbital of anions under the three-fold rotational symmetry. In this context, the coupling strength allows for being greatly enhanced by turning the nature of Cr-X bonds, i.e., increasing the covalent contribution of the bonds by minimizing the energy difference of the coupled orbitals. As we illustrate for the example of CrOY, the Curie temperature (TC) is nearly tripled by substituting O by S/Se ion, eventually reaching the highest TC in CrSeI monolayer (334 K). The high stabilities and Curie temperature manifest these monolayer ferromagnetic materials feasible for synthesis and applicable to 2D spintronic devices.
Invitro detection of biofilm produced by microorganism isolated from patients of periodontitis.
Authors: Mistry Yogita , Modi Palak , Vinchurkar Urjita , Piludariya Anvi , Parmar Gunvant , mullan Summaiya
Published: December 2022

Periodontal infections, including gingivitis and periodontitis, form a major group among the most encountered chronic diseases with infective etiologies. Microorganisms present in gingival sulcus around teeth form microbial biofilm, which is most important cause of periodontal diseases. Biofilm, a three-dimensional (3D) microbial structure with cells enclosed within a self-produced extracellular matrix that may be attached to a substratum comprises the structure of a biofilm. This study aims to detect biofilm in microorganisms isolated from periodontal pockets and establishment of relation between biofilm with tobacco chewing and comorbidies. Total 100 Patients’ samples were collected using Bent swab from periodontal lesions. Samples were processed aerobically and identification of the isolates are done along with simultaneous demonstration of in vitro biofilm formation. Biofilm production was detected by using pre sterilized 96 well polystyrene micro titre plates. 71 samples were shown growth of microorganisms like Streptococcus viridians (36), Klebsiella pneumoniae (21), E. coli (6), Klebsiella oxytoca (4), Acinetobacter baumannii (1), Pseudomonas aeruginosa (1), Staphylococcus aureus (1), Coagulase negative staphylococcus (1). 19 isolates of Streptococcus viridians have formed biofilm out of 36 isolates. 16 isolates of Klebsiella pneumoniae have formed biofilm out of 21 isolates. 3 isolates of Klebsiella oxytoca have formed biofilm out of total 4 isolates. 2 isolates of E. coli have formed biofilm out of 6 isolates. One isolate, each of Acinetobacter baumannii, CONS and Pseudomonas aeroginosa have formed biofilm. Out of 43 positive oral biofilms, 21% were tobacco chewers and out of negative oral biofilm, 15% were tobacco chewers. Among positive oral biofilms, 19% had comorbidities and among negative oral biofilm, 15% had comorbidity. The oral colonization by biofilm producing strains can also increase the risk of their dissemination to various human tissues and organs. Apart from that, biofilms cause resistance to many antimicrobial agents.
Abnormal spectral and scale-free properties of resting-state EEG in girls with Rett Syndrome
Authors: Sysoeva Olga , Maximenko Vladimir , Kuc Alexander , Voinova Victoria , Martynova Olga , Hramov Alexander
Published: December 2022

Spontaneous EEG contains important information about neuronal network properties that is valuable for understanding different neurological and psychiatric conditions. Rett syndrome (RTT) is a rare neurodevelopmental disorder, caused by mutation in the MECP2 gene. RTT is characterized by severe motor impairments that prevent adequate assessment of cognitive functions. Here we probe EEG parameters obtained in no visual input condition from a 28-channels system in 23 patients with Rett Syndrome and 38 their typically developing peers aged 3–17 years old. Confirming previous results, RTT showed a fronto-central theta power (4-6.25 Hz) increase that correlates with a progression of the disease. Alpha power (6.75–11.75 Hz) across multiple regions was, on the contrary, decreased in RTT, also corresponding to general background slowing reported previously. Among novel results we found an increase in gamma power (31-39.5 Hz) across frontal, central and temporal electrodes, suggesting elevated excitation/inhibition ratio. Long-range temporal correlation measured by detrended fluctuation analysis within 6–13 Hz was also increased, pointing to a more predictable oscillation pattern in RTT. Overall measured EEG parameters allow to differentiate groups with high accuracy, ROC AUC value of 0.92 ± 0.08, indicating clinical relevance.
Fuzzy weighted multi-kernel subspace co-clustering based on structural-α entropy
Authors: Zhang Kexin
Published: December 2022

Co-clustering, which combines the rows and columns of data matrix, has achieved widespread success in many application fields. For further improving performance of clustering algorithm, we introduce the structural-α entropy of weighting vector of the co-clustering model, constructing a structural-α entropy weighting subspace clustering model, theoretically derived structural-α entropy weighting subspace two-way subspace clustering algorithm STWCC. This algorithm not only can discover clusters in different subspaces but also discover the relationship between samples and features of different subspaces in the data space, better revealing the relations between samples and features of data by maximizing the weighting entropy. On this basis, the fuzzy weighted kernel space joint clustering model of structural-α entropy is obtained by introducing fuzzy entropy of membership. By introducing the kernel method, the weighted kernel space joint clustering model of structural-α entropy is obtained. By introducing the autoencoder, the weighted subspace co-clustering model of structural-α entropy of auto-encoder is obtained, and the corresponding algorithm is derived. The proposed algorithm is experimented with synthetic datasets, and real datasets including UCI standard datasets, and is compared with some typical clustering algorithms. The results show that the proposed algorithm has a certain improvement in performance.
Therapeutic effect of clonazepam in BMS patients according to underlying medical condition; Do xerostomia, psychiatric problem and taste change affect treatment response?
Authors: Shin Hyun-Il , Bang Joo-In , Kim Geun-Jeon , Kim Mi-Ra , Sun Dong-Il , Kim Sang-Yeon
Published: December 2022

Background
Burning mouth syndrome (BMS) is frequently accompanied by dysgeusia and xerostomia. Clonazepam has been widely prescribed and is effective, but it is unclear whether clonazepam also affects the symptoms that accompany BMS, or whether such symptoms affect treatment outcomes. Here, we investigated the therapeutic outcomes in BMS patients with various comorbidities.
Materials and Methods
We retrospectively reviewed 41 patients diagnosed with BMS between June 2010 and June 2021 at a single institution. Patients were instructed to take clonazepam for 6 weeks. Before the first dose, burning pain intensity was measured using a visual analog scale (VAS); the unstimulated salivary flow rate (USFR), psychiatric characteristics, site(s) of pain, and any taste disturbance were evaluated. Burning pain intensity was measured again after 6 weeks.
Results
Thirty-one of the 41 patents (75.7%) exhibited a depressed mood, whereas more than 67.8% of the patients exhibited anxiety. Subjective xerostomia was reported by 10 patients (24.3%). The mean salivary flow rate was 0.69 mL/min and hyposalivation (an unstimulated salivary flow rate ≤ 0.5 mL/min) was apparent in 10 patients (24.3%). Dysgeusia was present in 20 patients (48.7%); a bitter taste (n = 15, 75%) was reported by the largest proportion of patients. Patients who reported a bitter taste responded best in terms of burning pain reduction after 6 weeks (n = 4, 26.6%). Overall, 32 patients (78%) reported decreased oral burning pain after clonazepam (mean VAS score changed from 6.56 to 5.34) use. Patients who reported taste disturbances exhibited a significantly greater decrease in burning pain, compared with other patients (mean VAS score changed from 6.41 to 4.58) (p = 0.02)
Conclusion
Clonazepam significantly improved burning pain in BMS patients who had taste disturbances.
OsSAPK3 improves drought resistance and grain yield in rice
Authors: Lou Dengji , Lu Suping , Chen Zhen , Lin Yi , Yu Diqiu , Yang Xiaoyan
Published: December 2022

Background: The sucrose non-fermenting 1-related kinases 2 (SnRK2s) are crucial for abiotic stress responses in rice. Therefore, it is necessary to clarify the special function of SnRK2s. As one of SnRK2II members in rice, the function of Osmotic stress/ABA–activated protein kinase 3 (OsSAPK3) is unclear.
Results: OsSAPK3 was induced by drought, NaCl, PEG and ABA. OsSAPK3 knockout seedings (sapk3-1and sapk3-2) decreased the hypersensitivity to exogenous ABA. In addition, sapk3-1and sapk3-2 showed decreased stress tolerance, including lower survival rates, higher water loss rate under drought stress, increased stomatal conductance and remarkably decreased expression of SLAC1 and SLAC7.Physiological and metabolic analyses showed that OsSAPK3 might play an important role in abiotic stress signaling pathway by influencing accumulation of compatible osmolytes, reactive oxygen species (ROS) detoxification and expression of dehydration-responsive genes. Agronomic traits analyses demonstrated that OsSAPK3 could improve rice yield by participating in the regulation of tiller numbers and grain size. The experimental of tiller bud development suggested that OsSAPK3 might regulate rice tiller numbers by affecting the growth of axillary buds via promoting expression of nitrate transporter genes.
Conclusion: OsSAPK3 may play an important role in both ABA-dependent and ABA-independent abiotic stresss signaling pathways. In addition, OsSAPK3could improve rice yield by participating in the regulation of tiller numbers and grain size. These findings provide new insight for functional analysis of SnRK2s and engineering of drought resistant rice.
Mitogenome of the Brazilian critically endangered pitviper Bothrops insularis – structural genomic characterization and evolutionary aspects
Authors: Salles-Oliveira I , Patané JSL , Nishiyama MY , Silva MJJ
Published: December 2022

Background: Analyses of mitogenome structure and its evolution have provided new insights of species evolution and helped to improve in situ and ex situ conservation strategies. Although the characterization of snakes mitogenomes have been improved, the access of neotropical species molecules is still scarce, such as the case of Bothrops insularis. B. insularis is a Brazilian critically endangered snake which genomic characterization could improve information related to its evolutionary history and conservation strategies delimitation. Here we characterize for the first time the mitogenome of B. insularis, compare it with other mitogenomes available for the genus Bothrops, and used those genomes to recover the putative phylogenetic context in which the species evolved. \
Results: B. insularis mitogenome is a circular molecule with 17,523 bp length, encompassing 13 protein-coding genes, 22 tRNA, two rRNA, two control regions, one region of the light strand origin replication, a duplicate tRNA-Phe, and a non-coding region. Within the genus Bothrops mitogenomes diverge due to the presence of tRNA duplications and non-coding regions. Despite the divergences found in the mitogenome nucleotide composition and structure, evidence of positive selection was not observed in B. insularis. Comparisons among 129 snake species allowed us to identify 18 mitotypes, which originated from rearrangement processes within three tRNA clusters: the WAN-Ol-CY; the CR regions and adjacent tRNA; and the S2D cluster. These processes might have occurred in the family (Mitogenome 3B and variants), subfamily (Mitogenome 3D and variants), and species-specific levels.
Conclusion: Our results provide the first description of B. insularis mitogenome, which reinforce its evolutionary significant unit status, in agreement with previous ecological, genetic, and evolutionary data. Moreover, we report a higher diversity of gene order and structure within snake mitogenomes which brings another question to be investigated: mitotypes could be correlated to habits or habitats?
Robust Weld Seam Tracking Method Based on Detection and Tracking of Laser Stripe
Authors: Wang Nianfeng , Yang Jialin , Zhong Kaifan , Zhang Xianmin , Gong Tao
Published: December 2022

In the automatic welding system based on structured light vision, the precision of detection of
the welding feature point in the weld image plays a critical role. Due to various interferences
captured in a complex welding environment, it is essential to extract the feature point accurately.
A practical and robust welding seam tracking algorithm by considering the welding
feature point detection problem as the detection and tracking of laser stripes is proposed in this
paper. In the initial image, the laser stripe candidates are detected by searching the peak of the
gray distribution and the actual laser stripe is extracted by the similarity between real image
and simulated image. The laser stripe is tracked based on the improved mean shift tracking
method with the patch-based representation in the sequent images. The real-time performance
and accuracy of the proposed algorithm are demonstrated by comparison with other methods
through experiments.
Shotgun Proteomics-based distinctive fingerprint of sperm-surface revealed over- representation of proteins driving spermatogenesis, motility, and fertility
Authors: Batra Vipul , Dagar Komal , Diwakar Maharana Pratap , Kumaresan Arumugam , Kumar Rakesh , Datta Tirtha Kumar
Published: December 2022

Background Numerous distinct secretagogues such as (glyco) proteins including the GPI-anchored proteins are added to the sperm surface during their transit through the male reproductive tract (MRT). This remodelling of the sperm surface is critical for sperm maturation, survival and function in the female reproductive tract (FRT). This study aimed to characterize the proteins present on the buffalo sperm surface. Results A buffalo sperm surface-specific proteomic fingerprint was generated using shotgun proteomics (LC-MS/MS). The protein informatics platform, Proteome Discoverer (v2.2) identified 1342, 678, and 982 distinct proteins and isoforms (P < 0.05, FDR < 0.01) in the salt-extracted, PI-PLC treated and capacitated samples, respectively. Overall, 1695 unique proteins (minimum 2 peptides) with ≥ 1 high-quality PSM/s and their isoforms (proteoforms) were identified. Descriptive statistical analysis indicated that these buffalo-specific proteoforms exhibit remarkable heterogeneity in their molecular weight, pI, distribution of expression from the genome and their functional roles in the MRT and the FRT. Subsequent analysis and a thorough literature search revealed that the fertility-related, reproduction-specific proteoforms constituted more than 50% (873) of the identified sperm-surface proteome (1695). Discussion These identified proteoforms are unique to buffalo since a buffalo-specific database, NCBI reference proteome (translated from the latest chromosome level genome assembly, (UOA_WB_1) was used as the search space. These proteoforms were mapped to 252 buffalo-specific proteins implicated in the regulation of various aspects of male reproductive physiology across multiple species. Besides, more than 200 orphan, buffalo-specific proteins and their isoforms (undefined locus, uncharacterized, P < 0.05, FDR < 0.01) were also identified using our computational strategy. This allowed us to consider these novel proteins for considered for mapping their ontology terms. This led to the elucidation of the biological functions of these hitherto unreported, buffalo-specific proteins by extrapolation of function from their sequence orthologs in more several ruminant and non-ruminant (e.g. Primates and Rodents) mammalian. These uncharacterized proteins constitute an extensive, yet unexplored, reproduction-specific sperm-surface proteome repertoire. Conclusions The proteomic signature driving the buffalo sperm production, maturation, survival and function discovered in this study is unparalleled vis-à-vis the depth identification of fertility-related and reproduction-specific cell-surface proteins. These results would facilitate advances in understanding the functional roles of proteins implicated in mammalian sperm function.
Update to the study protocol “Face Your Fears: Virtual reality-based cognitive behavioral therapy (VR-CBT) versus standard CBT for paranoid ideations in patients with schizophrenia spectrum disorders: A randomized clinical trial”
Authors: Jeppesen Ulrik Nykjaer , Due Anne Sofie , Mariegaard Lise , Pinkham Amy , Vos Maarten , Veling Wim , Nordentoft Merete , Glenthøj Louise Birkedal
Published: December 2022

We unfortunately need to make an update to our published study protocol that describes a significant change in the design of the study. The Committee on Health Research Ethics of the Capital Region Denmark recently rejected the approval of changing the primary outcome in the trial, on the invariable grounds that the trial has already commenced. It is therefore necessary to retain the Green Paranoid Thought Scale (GPTS) part B, ideas of persecution, as our primary outcome and GPTS part A, ideas of social reference, as a secondary outcome, which is described opposite in our published study protocol. The exchange of outcomes has not affected participation in our trial or the informed consent. Intervention in both groups and assessments are unchanged. The two outcomes together constitute the Green Paranoid Thought Scale (GPTS) and the unifying concept we attempt to treat, namely paranoid ideations. As this is a blinded, methodologically rigorous trial, we did not have - and still do not have - access to preliminary data, and therefore, we have no knowledge of the distribution of our two intervention groups nor the potential effect of the intervention. The power calculation remains unchanged irrespective of the selection of primary outcome. We have been fully transparent with the changes in primary and secondary outcomes on Clinicaltrials.gov throughout the trial. Due to the considerations mentioned above, we assumed that there would not be any ethical implications of the change of primary outcome. We sincerely apologize for the irregularity caused because of this assumption. Trial Registration ClinicalTrials.gov Identifier: NCT04902066. Initial release April 9th, 2021. https://www.clinicaltrials.gov/ct2/show/NCT04902066
Effects of once-weekly semaglutide in obese/overweight patients: A systematic review and meta-analysis
Authors: Wang Mengjun , Wang Ning , Zhang Haixiong , Liu Junliang , Chen Xi , Feng Yingqian , Nan Jing , Sun Bo
Published: December 2022

Background:
Pharmacological options for management of overweight or obesity in adults are limited, several large scale trials about semaglutide published recently require updated evidence synthesis.
Objective：
To investigate the safety and efficacy of once-weekly glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide in patients with overweight or obesity.
Methods:
Database including PubMed, Embase, Cochrane Library, and Scopus were searched up until Jan 27, 2022. Randomised controlled trials with ≥12 weeks of treatment evaluating once-weekly semaglutide or placebo in obese/overweight adults. Primary outcome was change from baseline in weight. Secondary endpoints included proportion of patients achieving body weight targets and change from baseline in weight, body mass index (BMI), waist circumferences (WC), glucose, blood lipids and blood pressure levels, gastrointestinal adverse effects. Subgroup analysis was performed according to different dosages of semaglutide. Odds ratio (OR) and weighted mean difference (WMD) with 95% confidence intervals (CI) were used to evaluate the overall outcomes. Intertrial heterogeneity across studies was examined by I2 and Q statistics.
Results:
Finally, 9 studies comprising a total of 5324 patients were included in the meta-analysis. Compared with placebo, semaglutide was more effective in reducing body weight (WMD: 5.52 kg, 95% CI:-7.35kg, -5.78kg, P <0.00001) and percentage of body weight by 10.88% (95% CI:-12.98%, -8.79%). The proportion of patients achieving body weight targets was significantly higher in semaglutide-treated patients compared to placebo. Semaglutide also reduced BMI and WC, and benefited glycaemic, blood pressure and triglyceride regulation. And, semaglutide has a beneficial effect on health-related quality of life. However, the incidence of gastrointestinal side effects was significantly higher in patients treated with semaglutide.
Conclusions:
Once weekly semaglutide could be an optimal therapeutic choice for obesity or overweight patients.