bluuebunny/crossref_metadata_2025 huggingface dataset:
Validation of a photogrammetric approach for the objective study of early bowed instruments
Authors: Beghin Philémon , Ceulemans Anne-Emmanuelle , Fisette Paul , Glineur François
Published: August 2023

Some early violins have been reduced during their history to fit imposed morphological standards, while more recent ones have been built directly to these standards. We propose an objective photogrammetric approach to differentiate between a reduced and an unreduced instrument, whereby a three-dimensional mesh is studied geometrically by examining 2D slices. Our contribution is twofold. First, we validate the quality of the photogrammetric mesh through a comparison with reference images obtained by medical imaging, and conclude that a sub-millimetre accuracy is achieved. Then, we show how quantitative and qualitative features such as contour lines, channel of minima and a measure of asymmetry between the upper and lower surfaces of a violin can be automatically extracted from the validated photogrammetric meshes, allowing to successfully highlight differences between instruments.

Graphical Abstract
Liquid chromatography-tandem mass spectrometry for pharmacokinetics evaluation of AZD5305, a selective PARP1 inhibitor, in mice
Authors: Lee Gi Ju , Kim Jin Woo , Choi Hae-In , Choi Jin Young , Cho Kwan Hyung , Koo Tae-Sung
Published: August 2023

Poly (ADP-ribose) polymerase (PARP) inhibitors that are effective against ovarian and breast cancers with breast cancer susceptibility gene (BRCA) mutations have undesirable side effects, such as hematological toxicity. AZD5305, a selective PARP1 inhibitor currently in Phase 1/2 clinical trials, may avoid the side effects caused by PARP2. However, the in vivo pharmacokinetic characteristics of AZD5305 and its bioanalytical methods are unknown. Therefore, a method based on liquid chromatography with tandem mass spectroscopy (LC–MS/MS) was developed and validated to quantify AZD5305 in plasma of mice. Optimal chromatographic separation in terms of peak intensity and symmetry was acquired using a 4-µm Polar-RP 80 Å (2.0 × 150 mm) column with ammonium acetate (5 mM) in distilled water–acetonitrile (50:50, v/v). The retention times of AZD5305 and internal standard (IS; olaparib) were 1.82 min and 1.99 min, respectively. Detection was carried out via triple quadrupole mass spectrometry in positive ion mode employing multiple reaction monitoring transitions at m/z 407.0 → 376.0 for AZD5305 and m/z 435.0 → 281.2 for the IS. The LC–MS/MS method was linear in the range 1–1000 ng/mL with a correlation coefficient ≥ 0.990 and showed acceptable values of major parameters including accuracy, precision, and recovery. Additionally, AZD5305 showed high stability under various conditions. The in vivo and in vitro pharmacokinetics of AZD5305 were successfully characterized by employing the validated LC–MS/MS method. A high level of drug exposure and linear pharmacokinetics were observed after intravenous (IV) bolus and oral administration (PO) of AZD5305 at 0.1–1 mg/kg and 0.1–3 mg/kg, respectively. The bioavailability was close to 100%, and the metabolic stability of AZD5305 in hepatic microsomes of mice and humans was very high. These results may contribute to the improvement of PARP inhibitors that are used to treat malignancies originating from BRCA mutations.
On the genesis of multi-peak vertical structure of quasi-two-day waves in the mesosphere–lower thermosphere
Authors: Prijith S. S. , Kishore Kumar K.
Published: August 2023

The study presents multi-peak vertical structure of westward propagating quasi-two-day wave with wave-number 3 (W3) and its formation mechanisms in the mesosphere–lower thermosphere, using two decades of multi-satellite measurements, for the first time. W3 in austral summer shows a multi peak vertical structure, with two prominent peaks having amplitudes of 11.24 ± 2.2 K and 8.66 ± 1.1 K at 108 km (M1) and 84 km (M2), respectively. Genesis of this multi-peak structure, which is not explored in details hitherto, is investigated. While weak eastward/westward winds favour vertical growth of W3 in the regions of M1 and M2, strong eastward winds weaken W3 in the region between M1 and M2. These changes in zonal winds are modulated by the altitude variations in meridional temperature gradient and gravity wave filtering. Thus, vertically alternating changes in wind and meridional temperature gradient are the potential drivers for the multi-peak vertical structure of W3, which will be of importance for atmosphere–ionosphere coupling processes.

Graphical Abstract
Smoking and secondary ACL rupture are detrimental to knee health post ACL injury—a Bayesian analysis
Authors: Nicholls Micah , Ingvarsson Thorvaldur , Filbay Stephanie , Lohmander Stefan , Briem Kristin
Published: August 2023

Purpose

To identify potential prognostic factors for patient‐reported outcomes in an Icelandic cohort of ACL injured subjects.

Methods

All knee MRI reports written in Iceland between the years 2001 to 2011 were read to identify individuals with a possible ACL injury. These individuals were contacted and asked to complete an online questionnaire regarding their injury and current knee related health. The questionnaire collected information on years since surgery, injury circumstance, brace use, physiotherapy, ACL surgery, second ACL injury and current smoking status. In addition, the baseline status of their meniscii were assessed from the original MRI report and medical records were used to identify any subsequent, non‐ACL surgery. The patient‐reported Knee Osteoarthritis and Injury Outcome Score (KOOS) was used assess current knee related health. A Bayesian proportional odds model was used to assess the effect of all potential prognostic factors above as well as age and sex on KOOS outcomes.

Results

A total of 408 subjects completed the questionnaire indicating that they did rupture their ACL. The following variables were associated with worse outcomes across all KOOS subscales: having a subsequent arthroscopy, reinjury to your ACL, and smoking. Having physiotherapy for 9 months was associated with worse KOOS pain scores than having 6 months of physiotherapy. Conversely KOOS pain score tended to be higher if you injured your knee during sports.

Conclusion

Reinjuring your ACL, smoking and having subsequent (non‐ACLR) surgery predict your knee related health following an ACL injury. Strategies should be implemented to reduce the risk of secondary ACL injury, and patients should be strongly advised not to smoke.
Perioperative lung function following flow controlled ventilation for robot-assisted prostatectomies in steep trendelenburg position: an observational study
Authors: Syrafe Mustafa , Köhne Wiebke , Börgers Andre , Löwen Heinrich , Krege Susanne , Groeben Harald
Published: August 2023

Background

Steep Trendelenburg position combined with capnoperitoneum can lead to pulmonary complications and prolonged affection of postoperative lung function. Changes in pulmonary function occur independent of different modes of ventilation and levels of positive end-expiratory pressure (PEEP). The effect of flow-controlled ventilation (FCV) has not been evaluated yet. We perioperatively measured spirometric lung function parameters in patients undergoing robot-assisted prostatectomy under FCV. Our primary hypothesis was that there is no significant difference in the ratio of the maximal mid expiratory and inspiratory flow (MEF50/MIF50) after surgery.

Methods

In 20 patients, spirometric measurements were obtained preoperatively, 40, 120, and 240 min and 1 and 5 days postoperatively. We measured MEF50/MIF50, vital capacity (VC), forced expiratory volume in 1 s (FEV1), and intraoperative ventilation parameters.

Results

MEF50/MIF50 ratio increased from 0.92 (CI 0.73–1.11) to 1.38 (CI 1.01–1.75,p < 0.0001) and returned to baseline within 24 h, while VC and FEV1 decreased postoperatively with a second nadir at 24 h and only normalized by the fifth day (p < 0.0001). Compared to patients with PCV, postoperative lung function changes similarly.

Conclusion

Flow-controlled ventilation led to changes in lung function similar to those observed with pressure-controlled ventilation. While the ratio of MEF50/MIF50 normalized within 24 h, VC and FEV1 recovered within 5 days after surgery.
Successful endovascular embolization of the common hepatic artery for pseudoaneurysm associated with pancreatic fistula after liver transplantation: a case report
Authors: Sasaki Kazuki , Asaoka Tadafumi , Kobayashi Shogo , Iwagami Yoshifumi , Yamada Daisaku , Tomimaru Yoshito , Noda Takehiro , Wada Hiroshi , Gotoh Kunihito , Takahashi Hidenori , Maeda Noboru , Kimura Yasushi , Ono Yusuke , Doki Yuichiro , Eguchi Hidetoshi
Published: August 2023

Background

After orthotopic liver transplantation (OLT), complications such as hepatic artery stenosis, thrombosis, and bleeding are possible. Hepatic artery pseudoaneurysms (HAP) are prone to rupture, rupture hemorrhage, and increased mortality risk. Endovascular treatment of HAP may result in recurrence, even after successful embolization with thrombin. Formation of a HAP in the common hepatic artery (CHA) is challenging because the CHA is the only artery in the liver graft after OLT. Therefore, CHA embolization in HAP is not an initial option. We report a case of HAP at the CHA after OLT that was treated with endovascular therapy, resulting in the occlusion of the CHA with coil embolization, achieving a radical cure.

Case presentation

A 59-year-old man with decompensated hepatitis C virus cirrhosis underwent deceased donor whole-liver transplantation after graft failure of a living donor liver transplantation. After the second transplantation, the patient developed infectious narrow-necked HAP at the CHA associated with postoperative pancreatic fistula. Repeated transcatheter arterial embolization with thrombin and n-butyl-2-cyanoacrylate was unsuccessful, as confirmed by postprocedure angiography, which revealed recanalization and regrowth of the HAP. Eight months after the first transcatheter arterial embolization, the patient presented with a chief complaint of abdominal pain due to an enlarged HAP. Angiography of the superior mesenteric artery (SMA) revealed a collateral bypass around the bile duct from the SMA to the liver graft. Coil embolization of the HAP in the CHA completely occluded the HAP without complications. More than 2 years after coil embolization, the liver graft function test results remained within normal limits without HAP recurrence.

Conclusions

HAP at the CHA after liver transplantation can be fatal if ruptured. Because the liver is a highly angiogenic organ, even if initial treatment is not successful, radical treatment to occlude the CHA with HAP is possible if sufficient collateral vessels are developed.
Tubular intestinal duplication extending from the stomach to the ileum associated with multiple intestinal atresia and situs inversus: a case report
Authors: Higashidate Naruki , Sakamoto Saki , Saikusa Nobuyuki , Koga Yoshinori , Masui Daisuke , Nakahara Hirotomo , Nakamura Misa , Saikusa Mamoru , Kinoshita Masahiro , Kaji Tatsuru
Published: August 2023

Background

Duplication of the alimentary tract can occur in any of its parts. For duodenal duplication, complete resection is particularly difficult when the ampulla of Vater is on the duplicated lumen and a deliberate management is necessary.

Case presentation

A 0-day female baby was referred to our department due to abdominal distention. The X-ray examination showed dextrocardia and opacity of the liver on the left side and abdominal ultrasonogram revealed remarkable intestinal dilatation. Therefore, urgent laparotomy was performed on the day of birth. Complete situs inversus of the abdominal organs was revealed, and the origin of the jejunum was on the left side and was accompanied by tubular intestinal duplication. The origin of the duplicated intestine was at the pancreatic head’s dorsal area. There were two points of type Шa atresia on the ileum. Therefore, we spared the duplicated intestine with a length of 3 cm to secure the passage of the biliary and pancreatic juices by a functional-side-to-side anastomosis with a 45-mm Endo-GIA™ camel load (Medtronic, Minneapolis, MN, USA). The ileum was transected at the distal side of the atresia point, and end-to-end jejunoileostomy was performed. Postoperative gastrointestinal series revealed remnants of the duplicated alimentary tract on the dorsal area of the stomach.

Conclusions

Identifying the position of the ampulla of Vater is crucial in the surgery of alimentary tract duplication with duodenal involvement. However, in the present case, it was difficult to identify whether the ampulla of Vater was on the true or duplicated lumen, and we had to spare the duplicated duodenum. Stapler anastomosis could be performed safely even in neonatal cases.
Hypnosis to reduce fear of falling in hospitalized older adults: a feasibility randomized controlled trial
Authors: Cuvelier Clémence , Hars Mélany , Zamorani-Bianchi Maria Pia , Herrmann François R. , Wieczorkiewicz Catherine Ducharne , Zekry Dina , Gold Gabriel , Trombetti Andrea
Published: August 2023

Abstract

Background

Fear of falling is associated with numerous negative health outcomes in older adults and can limit the rehabilitation process. Hypnosis is now recognized as an effective treatment for a variety of conditions, especially anxiety and pain, which can be integrated safely with conventional medicine. The objective of this study was to assess the feasibility and acceptability of a hypnosis intervention in hospitalized older adults to reduce fear of falling.

Methods

In this feasibility randomized controlled trial, 32 older patients, hospitalized in geriatric rehabilitation wards, were randomly allocated (1:1 ratio) to either an intervention group (hypnosis, 2 sessions, one per week, plus usual rehabilitation program) or a control group (usual rehabilitation program only). Clinical assessors and statistician were blinded to group allocation. Primary outcomes were recruitment rate, retention rate, and adherence to the intervention. Exploratory outcomes, analyzed according to the intention-to-treat principle, included impact of hypnosis on fear of falling (assessed by a new scale perform-FES), functional status, in-hospital falls, and length of hospital stay.

Results

Recruitment rate was 1.3 patients per week. The recruitment of the population sample was achieved in 5.5 months. The retention rate did not differ significantly between groups and a good adherence to the hypnosis intervention was achieved (77% of patients received the full intervention). No adverse event related to the hypnosis intervention was observed. Regarding exploratory clinical outcomes, no differences were found between groups on any outcome.

Conclusion

Hypnosis is feasible and well accepted in a geriatric hospitalized population undergoing rehabilitation. Further pilot work should be conducted, with an increased number of hypnosis sessions, before conducting a full-scale trial to conclude whether, or not, hypnosis is effective to reduce fear of falling.

Trial registration

NCT04726774.
Development and validation of a simulation-based assessment tool in colonoscopy
Authors: Jaensch Claudia , Jensen Rune D. , Paltved Charlotte , Madsen Anders H.
Published: August 2023

Background

Colonoscopy is difficult to learn. Virtual reality simulation training is helpful, but how and when novices should progress to patient-based training has yet to be established. To date, there is no assessment tool for credentialing novice endoscopists prior to clinical practice. The aim of this study was to develop such an assessment tool based on metrics provided by the simulator. The metrics used for the assessment tool should be able to discriminate between novices, intermediates, and experts and include essential checklist items for patient safety.

Methods

The validation process was conducted based on the Standards for Educational and Psychological Testing. An expert panel decided upon three essential checklist items for patient safety based on Lawshe’s method: perforation, hazardous tension to the bowel wall, and cecal intubation. A power calculation was performed. In this study, the Simbionix GI Mentor II simulator was used. Metrics with discriminatory ability were identified with variance analysis and combined to form an aggregate score. Based on this score and the essential items, pass/fail standards were set and reliability was tested.

Results

Twenty-four participants (eight novices, eight intermediates, and eight expert endoscopists) performed two simulated colonoscopies. Four metrics with discriminatory ability were identified. The aggregate score ranged from 4.2 to 51.2 points. Novices had a mean score of 10.00 (SD 5.13), intermediates 24.63 (SD 7.91), and experts 30.72 (SD 11.98). The difference in score between novices and the other two groups was statistically significant (p<0.01). Although expert endoscopists had a higher score, the difference was not statistically significant (p=0.40). Reliability was good (Cronbach’s alpha=0.86). A pass/fail score was defined at 17.1 points with correct completion of three essential checklist items, resulting in three experts and three intermediates failing and one novice passing the assessment.

Conclusion

We established a valid and reliable assessment tool with a pass/fail standard on the simulator. We suggest using the assessment after simulation-based training before commencing work-based learning.
Effectiveness of music-based interventions for cognitive rehabilitation in Parkinson’s disease: a systematic review of randomized controlled clinical trials
Authors: Citon Leonardo Francisco , Hamdan Amer Cavalheiro
Published: August 2023

Background

Music-based interventions are promising for cognitive rehabilitation in Parkinson’s disease; however, systematic reviews covering the topic are scarce.

Objective

To analyze the effectiveness of music-based interventions for cognitive rehabilitation in PD.

Method

Systematic review study based on PRISMA criteria. The descriptors Parkinson’s disease, Parkinson’s disease, idiopathic Parkinson’s disease, music-based interventions, music therapy, music training, auditory stimulation, music, rhythm, rhythmic, cognition, and cognitive were used. Five databases were searched PubMed/MEDLINE, PsycInfo, Scopus, Web of Science, and Cochrane in May 2022. Only randomized controlled trials with no limit on publication date or language were included. Risk of bias was assessed following Cochrane Collaboration criteria for development of systematic intervention reviews.

Results

Nine hundred nineteen articles were found by the descriptors; 266 were excluded for being repeated; 650 for not meeting the inclusion criteria. The remaining three articles were included and analyzed. The interventions consisted of practices with emphasis on rhythm and were conducted in groups. Risks of important biases were observed, such as lack of blinding in the allocation of participants and in the assessment of outcomes, as well as incomplete data for some outcomes.

Conclusion

Overall, the results showed no evidence of efficacy of music-based interventions for cognitive outcomes in PD.
Toxic effect of cyanobacterial (blue–green algae) extracts as natural pesticides for the control of Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)
Authors: Sharanappa C. H. , Bheemanna M. , Prabhuraj A. , Harischandra R. Naik , Nagaraj M. Naik , Saroja N. Rao , Kariyanna B.
Published: August 2023

Background

TheSpodoptera frugiperda(J. E. Smith) (Lepidoptera: Noctuidae) is a cosmopolitan polyphagous pest that feeds on nearly 80 species of plants The pest can cause upto 100% damage to crops if neglected. It is also resistant to the most of the chemical molecules available in the market, so it is necessary to identify alternate technology to combat this pest.

Results

The crude cyanobacterial extracts of hexane, petroleum ether, ethanol and methanol extracts ofSpirulinasp. andNostoc muscorumwere evaluated against second instar larvae ofS. frugiperdathrough diet overlay method of bioassay. The results revealed thatN. muscorumhexane extract andN. muscorumpetroleum ether extract recorded the lowest LC50value of 49.09 and 61.37 ppm, respectively. This was followed bySpirulinahexane extract,Spirulinapetroleum ether extract,N. muscorumethanol extract,N. muscorummethanol extract,Spirulinaethanol and methanol extract which were recorded 173.16, 227.22, 530, 730, 970 and 1000 ppm, respectively. Further, their potential effects on different biological parameters ofS. frugiperda,viz. larval duration, pupal duration, percent pupation, pupal weight, pupal malformation, adult malformation, percent adult emergence, fecundity, and male and female adult longevity, were studied. The significant effects on different biological parameters were recorded byN. muscorumhexane and petroleum ether extract, followed bySpirulinahexane and petroleum ether extract. Similarly, an experiment was repeated for the confirmation of the first set of results, which followed by a similar trend. The first-ever novel study onS. frugiperdaconcluded that crude extracts ofSpirulinasp. andN. muscorumextracts showed significant effects in causing larval mortality and affecting different biological parameters.

Conclusions

The experimental results can be recommended as a potential source of natural pesticides for the control ofS. frugiperda.
Static and natural frequency investigation of FGP beams considering thermal effects and design parameters
Authors: Azizzadeh Arsalan , Behjat Bashir
Published: August 2023

This study presents a static analysis and natural frequency analysis of functionally graded laminated piezoelectric beams based on the Euler–Bernoulli theory using the finite element method. A simple power law is used to vary all material properties across the thickness, except for Poisson’s ratio. The effect of laminate configuration and volume fraction index on the deflection and natural frequency of beams made of functionally graded piezoelectric materials (FGPM) is investigated, and the relationship between deflection and different volume fraction indices under thermal, electrical, and mechanical loads is explored. The study shows that there is a certain volume fraction index that maximizes or minimizes deflection. Additionally, the variation of natural frequency in relation to the power law index is examined. The findings of this research are useful for the development of sensors and actuators in different environments, and the appropriate operation point of the structure can be selected based on the behavior of the sensor or actuator of the beam.
The barriers and facilitators to young people’s engagement with bidirectional digital sexual health interventions: a mixed methods systematic review
Authors: Bennett Clare , Musa Massirfufulay Kpehe , Carrier Judith , Edwards Deborah , Gillen Elizabeth , Sydor Anna , Dunn Catherine , Jones-Mahoney Kaye , Nute Alex , Kelly Daniel
Published: August 2023

Background

Sexual health is fundamental to the overall health and wellbeing of individuals and to the social and economic development of communities and countries. However, internationally young people endure a disproportionate burden of sexually transmitted infections and unintended pregnancies which can be associated with poor psycho-social outcomes. Digital sexual health interventions have been developed to increase young people’s access to sexual health services, but are currently underutilised.

Aim

This systematic review sought to identify the barriers and facilitators to young people’s engagement with bidirectional digital sexual health interventions, which are standalone two-way tailored interventions between a young person and healthcare professional.

Methods

The review was conducted in accordance with the JBI methodology for mixed methods systematic reviews, following a convergent integrated approach to synthesis and integration of qualitative and quantitative evidence. Searches of ten electronic databases were conducted, spanning database inception to January 2022. No restrictions were imposed on language, geographical location or community setting. All included studies were critically appraised with JBI Critical Appraisal tools. Data extraction was performed using standardised tools, followed by data transformation. Data synthesis followed the convergent integrated approach. Each stage was conducted by two independent reviewers.

Results

Eight thousand four hundred thirty-nine titles and abstracts and, subsequently, 255 full-texts underwent review. Nine studies were selected for inclusion with no studies added following forward and backward citation tracking. The included studies comprised three qualitative and six quantitative designs. Three meta synthesised findings were identified: (1) The design of a digital intervention for adolescent sexual health needs to reflect the end users’ specific needs (2) Young people need to feel comfortable when using a digital sexual health intervention (3) Potential barriers to engagement need to be addressed. The review identified that although barriers and facilitators to promoting young people’s engagement with bidirectional digital sexual health interventions are nuanced, young people’s privacy and security need to be prioritised for them to engage with digital interventions, regardless of the platform of choice.

Conclusions

Co-production of digital sexual health services, in partnership with young people, has shaped many of the insights reported in this systematic review. Further international research which places an emphasis on young people’s perspectives is vital to unleash the full potential of digital technology in this domain.
New wiggles from old cables: Data processing and imaging considerations
Authors: Bachrach Ran , Ramani Krishna , Kanrar Arindam , Gupta Shruti , Sayed Ali , Twynam Francesca , Busanello Gabriele , Raknes Espen B. , Ivanov Yuriy , Sagary Corinne
Published: August 2023

Distributed acoustic sensing (DAS) using fiber-optic cables as sensors has become a standard measurement technique in many industrialized settings. Geophysical applications have been mainly commercialized in the borehole environment. When deployed on the seabed (SB), horizontal analysis of DAS data poses new challenges due to the particularity of the receiver response and characteristics of DAS data. Recent acquisition of a 2D towed-streamer (TS) survey following the path of a communication cable (installed in 1998), which is interrogated continuously throughout the TS acquisition, enables us to jointly analyze SB-DAS and conventional TS data recorded using modern hydrophone streamer from acquisition, through different processing stages up to a migrated image. The SB-DAS recording from the old communication cable enables us to generate excellent P-wave and converted wave (PS) images of the subsurface. However, care is needed when recovering the high spatial frequencies damped by the nature of DAS measurements (which also may depend on the hardware used) and demonstrating the recovery of the signal within the data processing (DP) sequence. Our focus is on the challenges associated with the DP of entrenched marine cables. Given a simple TS processing sequence as a reference, we examine an equivalent recommended practice for signal analysis, DP, and imaging of SB-DAS data.
Pembrolizumab in Patients With Tumors With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry Study
Authors: Duvivier Herbert L. , Rothe Michael , Mangat Pam K. , Garrett-Mayer Elizabeth , Ahn Eugene R. , Al Baghdadi Tareq , Alva Ajjai S. , Dublis Stephanie A. , Cannon Timothy L. , Calfa Carmen J. , Li Rui , Behl Deepti , Chiu Vi K. , Gold Philip J. , Marr Alissa S. , Mileham Kathryn F. , Powell Steven Francis , Rodon Jordi , Thota Ramya , Grantham Gina N. , Gregory Abigail , Hinshaw Dominique C. , Halabi Susan , Schilsky Richard L.
Published: August 2023

#TAPUR results of pembrolizumab in various tumors with HTMB extend KEYNOTE-158 data that led to FDA approval in tumors with HTMB
Primary Adrenal Insufficiency Masked by an Eating Disorder Diagnosis in an Adolescent Male
Authors: Nichols Presley , Rahming Virginia , Weiner Alyson , Sopher Aviva B
Published: August 2023

We describe a 14-year-old male who was followed for several years for the diagnoses of avoidant restrictive food intake disorder and generalized anxiety disorder before being diagnosed with primary adrenal insufficiency (PAI) or Addison disease. The patient presented multiple times to different facilities with worsening symptoms of anorexia, nausea, vomiting, and anxiety in the months leading up to diagnosis of PAI. Dehydration and hypotension, occurring relatively late in the course of his illness, were attributed to poor intake and vomiting. Hyponatremia was attributed to his psychotropic medication, olanzapine, and to dehydration. During his third hospitalization, he was diagnosed with PAI; treatment with stress-dose glucocorticoid therapy resulted in rapid clinical improvement. This case serves as a reminder that adrenal insufficiency must be considered in the differential diagnosis of eating disorders because signs and symptoms of adrenal insufficiency can overlap and progress insidiously. Additionally, we recognize that the diagnostic process is intertwined with a patient's medical history and use this opportunity to discuss cognitive, specifically anchoring, bias in academic medicine.
Low back pain functional disability and associated factors: A cross-sectional study in Peruvian amateur athletes
Authors: Rosales-Rimache Jaime , Chavez-León Yaritza
Published: August 2023

Background: Low Back Pain Functional Disability is one of the most critical physical limitations found in athletes, even leading to their temporary or permanent retirement. In this sense, this research aimed to evaluate the frequency of lumbar functional disability and its associated factors.

Methods: We designed transversal research and evaluated athletes from the Peruvian Sports Institute (IPD) of Ica in athletics, basketball, and table tennis. We administered a file to obtain demographic and epidemiological data. We identified low back pain with the DN4 instrument (Douleur Neuropathique 4 Questions) and lumbar functional disability with the athlete's disability index.

Results: We evaluated 130 amateur athletes (table tennis=30, basketball=50, and athletics=50), with an average age of 23.9±8.2 years, and constituted 63.9% of men. 30% (CI95: 22.3-38.7%) of the population presented lumbar functional disability (moderate 56.4%, severe 30.8%, and very high 12.8%). Factors associated with lumbar functional disability were age (PR: 1.05, CI95: 1.01-1.09), female sex (PR: 2.21, CI95:  1.08-4.50) and neuropathic pain (PR: 0.35, CI95: 0.16-0.80).

Conclusions: The frequency of lumbar functional disability is high among athletes who practice table tennis, basketball, and athletics. It is crucial to strengthen fitness programs accompanied by a periodic medical evaluation that allows the timely identification of injuries and potential functional disability due to low back pain.
Progress for carbon dioxide geological storage in West Macedonia: A field and laboratory-based survey
Authors: Tyrologou Pavlos , Vamvaka Agnes , Koukouzas Nikolaos , Pedro Jorge , Fleury Marc , Carneiro Julio , Ribeiro Carlos , Ghikas Dina , Mpatsi Anna , Barradas João Pedro , Faria Paula , De Mesquita Lobo Veloso Fernanda
Published: August 2023

Background: It is widely acknowledged that carbon dioxide (CO2), a greenhouse gas, is largely responsible for climatic changes that can lead to warming or cooling in various places. This disturbs natural processes, creating instability and fragility of natural and social ecosystems. To combat climate change, without compromising technology advancements and maintaining production costs at acceptable levels, carbon capture and storage (CCS) technologies can be deployed to advance a non-disruptive energy transition. Capturing CO2 from industrial processes such as thermoelectric power stations, refineries, and cement factories and storing it in geological mediums is becoming a mature technology. Part of the Mesohellenic Basin, situated in Greek territory, is proposed as a potential area for CO2 storage in saline aquifers. This follows work previously done in the StrategyCCUS project, funded by the EU. The work is progressing under the Pilot Strategy, funded by the EU.

Methods: The current investigation includes geomechanical and petrophysical methods to characterise sedimentary formations for their potential to hold CO2 underground.

Results: Samples were found to have both low porosity and permeability while the corresponding uniaxial strength for the Tsotyli formation was 22 MPa, for Eptechori 35 MPa and Pentalofo 74 MPa.

Conclusions: The samples investigated indicate the potential to act as cap-rocks due to low porosity and permeability, but fluid pressure within the rock should remain within specified limits; otherwise, the rock may easily fracture and result in CO2 leakage or/and deform to allow the flow of CO 2. Further investigation is needed to identify reservoir rocks as well more sampling to allow for statistically significant results.
Hybrid Administrative Interfaces: Authority Delegation and Reversion in Strategic Alliances
Authors: Hanisch Marvin , Reuer Jeffrey J. , Haeussler Carolin , Devarakonda Shivaram V.
Published: August 2023

Steering committees are pivotal for governing complex collaborations by consensus to facilitate coordination and knowledge sharing. Although consensus-based governance promotes mutuality, it can also cause deadlocks, stalling expeditious decision making. We examine the conditions under which alliance partners delegate decision-making authority to steering committees as well as the conditions under which authority over discordant matters can be relocated to one of the alliance partners. We argue that joint coordination concerns increase the likelihood of authority delegation, whereas the higher costs and stakes associated with decision stalemates provide grounds for authority reversion. Empirical analyses of strategic alliances in the biopharmaceutical industry support our arguments. Our paper demonstrates the versatility of contractually defined administrative interfaces in alliance governance, allowing partners to coordinate bilaterally and adapt hierarchically as and when required.
AS VERTENTES DO MODO FANTÁSTICO NA ESCRITA DE LIA NEIVA
Authors: De Oliveira Martins Jucélia , Meireles da Silva Alexander
Published: August 2023

O presente estudo propõe-se investigar a presença e a forma como os gêneros que integram o fantástico (modo) se fazem presentes na produção da escritora carioca Lia Neiva. Analisando os contos “O Parafuso de ouro” (1987), “O androide perfeito” (2012) e “O casamento de Romualdo” (2018), que integram importantes coletâneas da referida autora, pretende-se apresentar uma amostra da riqueza presente nas obras literárias de Lia Neiva, enquanto objetos de múltiplas possibilidades de pesquisa dentro do fantástico nacional.
UMA ANÁLISE DO PPC DO MAGISTÉRIO INDÍGENA PARA OS AWAETE-PARAKANÃ
Authors: Junior Ribamar Ribeiro
Published: August 2023

Este trabalho tem como fundamento a análise do Projeto Político Pedagógico do Curso de Magistério Indígena que está sendo ofertado pelo Instituto Federal do Pará, Campus Rural de Marabá (IFPA/CRMB) aos Awaeté-Parakanã, na Terra Indígena Parakanã, que habitam numa área de 351.697,41 há, localizada nos municípios de Novo Repartimento e Itupiranga, PA. A pesquisa aborda aspectos que visam compreender algumas falas dos Awaeté desde o início do curso, insatisfeitos com metodologias e pela forma como se organizou a turma. O presente trabalho sistematiza as discussões feitas em vários momentos de reuniões de avaliação do curso e de inserção no componente curricular Educação Escolar Indígena e Pesquisa, uma das primeiras disciplinas a serem ministradas e que trouxe a visibilidade dessas questões. Para tanto, utilizo metodologia a pesquisa etnográfica e documental, com um olhar contextualizado dos espaços de avaliação e planejamento do curso. Ao apresentar análise do PPC, faço uma articulação com os elementos propostos, as contradições e apontamentos que estão centralizados nos documentos.
EDUCAR EM TEMPOS DE FAKE NEWS
Authors: Carvalho Felipe , Almeida Wallace Carriço de , Santos Edméa Oliveira dos , Menezes Marcos Vinícius Dias de , Pimentel Mariano , Maddalena Tania Lucía
Published: August 2023

V. 7, n. 2
EXPERIÊNCIAS PLURAIS COM O USO DAS TECNOLOGIAS DIGITAIS EM REDE
Authors: Carvalho Felipe , Almeida Wallace Carriço de , Menezes Marcos Vinícius Dias de , Santos Edméa , Pimentel Mariano , Maddalena Tania Lucía
Published: August 2023

v. 7, n. 3 (2023) - Currículo, Cibercultura e Povos Indígenas
Mechanism of wound repair in diabetic rats using nanosilver-free alginate dressing
Authors: Tang Ying , Jia Zeguo , Li Xueting , Zhao Xiaotong , Zhang Shiqi , Luo Li , Xia Li , Fang Zhaohui , Zhang Yuanzhi , Chen Mingwei
Published: August 2023

Objective:

Nanosilver-alginate dressing can effectively promote the healing of diabetic wounds in rats. However, due to the potential toxicity of nanosilver, its widespread application in hard-to-heal wound healing is limited. In the present study, the role and potential mechanism of nanosilver-free alginate gel (NSFAG) in the healing process of diabetic wounds were explored.

Method:

A diabetic rat skin wound model was established, and wounds were treated with saline (NC group), nanosilver gel (NSG group) or nanosilver-free alginate gel (NSFAG group) for seven consecutive days.

Results:

NSFAG significantly promoted wound healing and increased the content of protein and hydroxyproline in granulation tissues, and was superior to NSG (p<0.05). Immunohistochemical analyses revealed that the skin wound tissue structure of the NSFAG group was intact, and the number of skin appendages in the dermis layer was significantly higher compared with the NC group and the NSG group (p<0.05). Western blot analysis found that the protein expression of the epidermal stem cell marker molecules CK19 and CK14 as well the proliferation marker of keratinocytes Ki67 in the NSFAG group was significantly higher compared with the NC group or NSG group (p<0.05). Additionally, the proliferation marker of keratinocytes Ki67 in the NSFAG group was significantly higher compared with the NC or NSG group (p<0.05). Immunofluorescence staining analyses indicated that the CK19- and CK14-positive cells were mainly distributed around the epidermis and the newly formed appendages in the NSFAG group, and this result was not observed in the NC or NSG groups.

Conclusion:

The present findings demonstrate that NSFAG can effectively accelerate wound healing in diabetic rats by promoting epidermal stem cell proliferation and differentiation into skin cells, as well as formation of granulation tissue, suggesting that it can be a potential dressing for diabetic wounds.
The cost of sustainable production for basmati rice grown by the Fairtrade certified producers
Authors: Chakraborty Manab
Published: August 2023

The objective of the study is to understand the cost components of Basmati rice production, and whether the minimum price offered by Fairtrade International (FI) or the Government of India (GOI) adequately compensates the farmers.

The study adopted a survey method for the assessment of realities on the ground. Data was collected from 327 FI certified Basmati farmers in four major Indian states – Jammu, Haryana, Uttarakhand and Uttar Pradesh.

The main finding is that the Fairtrade Minimum Price (FMP), along with its premium, is 41 per cent to 78 per cent lower than the farmers’ costs for seed, labour, storage and transportation. The Minimum Support Price (MSP) provided by the GOI is 6 per cent higher than the FMP for the conventional Pusa variety, but 25 per cent lower than the FMP for organic Basmati. Neither the FMP or the MSP covers producers’ reported costs.

No study exists in India examining the cost of production of Basmati farmers under Fair Trade contracts. The study is an important contribution to the ongoing debate on the benefits of Fair Trade farming from the perspective of farmers.
The Entwinement of Spectacle and Specimen: Mount Vesuvius in the Late Eighteenth Century
Authors: Beachdel Thomas
Published: August 2023

abstract: Late eighteenth-century representational strategies of Vesuvius that combine spectacular images of eruption with scientifically informed ones of natural process show a clear, yet inadequately examined connection between the aesthetic category of the sublime and natural history. Visual material, such as that found in the 1768 supplement to the Encyclopédie (1751–72) and in William Hamilton's 1779 supplement to Campi Phlegraei (1776), suggests porous boundaries between aesthetics and natural history. The entwinement of spectacle and specimen was a crucial means of comprehending and describing volcanic phenomena. Examining the relationship between the sublime and natural history furthers a more nuanced comprehension of the sublime beyond the nascent genre of landscape painting or the discrete aesthetic category. It also creates a richer understanding of natural history as it transformed into more specialized, professional—or more "scientific"—disciplines, such as geology and volcanology.
Cover Essay: Stamping Soviet Cosmonauts, Craft, and Cosmos
Authors: Hill Rachel
Published: August 2023

abstract: The cover image for this edition of Technology and Culture is a franked Soviet stamp. Despite its seemingly unassuming form, this stamp celebrates a pivotal moment in spaceflight history: the first woman to complete a successful orbital flight in space, Valentina Tereshkova. The image draws together cosmonaut, early spacecraft operations, and emerging understandings of the Earth's upper atmosphere, to succinctly illustrate Tereshkova's achievement. Examining the stamp reveals how spaceflight technology, public spectacle, and Soviet secrecy result in very specific aesthetic forms that fuse technical accuracy with flights of fancy. Tracing the trajectories of these (un)intended aesthetic forms, thinking through how they develop and transform over time, demonstrates how some histories of technology are best unearthed via visual means. In doing so, this essay prompts historians of technology to take note of visual analysis as an important but underutilized tool for their craft.
The Camera and the Railway: Framing the Portuguese Empire and Technological Landscapes in Angola and Mozambique, 1880s–1910s
Authors: Pereira Hugo Silveira
Published: August 2023

abstract: Starting in the 1880s, Portugal invested in constructing railways in its African colonies, Angola and Mozambique. The aim was both to solidify Portuguese presence in territories disputed by other imperial nations and to facilitate exploration of the resources that imperial policymakers assumed existed in the colonial hinterland. To promote the perception that Portugal was an imperial nation, hundreds of photographs recorded the construction, inauguration, and operation of these new railways. Using a semiotics approach, this article analyzes photographs from various sources in Portugal to show how they helped create a novel technological landscape, underscoring the domestication of the territory and the civilization of its inhabitants by European rule, thus promoting it as a land of opportunity for European settlers. This focus adds to the debate claiming that photography was a crucial tool of empire serving European colonialism and imperialism in Africa.
The Living Machine: A Computational Approach to the Nineteenth-Century Language of Technology
Authors: Wilson Daniel C.S. , Ardanuy Mariona Coll , Beelen Kaspar , McGillivray Barbara , Ahnert Ruth
Published: August 2023

abstract: This article examines a long-standing question in the history of technology concerning the trope of the living machine. The authors do this by using a cutting-edge computational method, which they apply to large collections of digitized texts. In particular, they demonstrate the affordances of a neural language model for historical research. In a deliberate maneuver, the authors use a type of model, often portrayed as sentient today, to detect figures of speech in nineteenth-century texts that portrayed machines as self-acting, automatic, or alive. Their masked language model detects unusual or surprising turns of phrase, which could not be discovered using simple keyword search. The authors collect and close read such sentences to explore how figurative language produced a context that conceived humans and machines as interchangeable in complicated ways. They conclude that, used judiciously, language models have the potential to open up new avenues of historical research.
Temperature and strain simultaneous sensing measurement based on an all-fiber Mach-Zehnder interferometer and fiber Bragg grating
Authors: Zhu Junjie , He Wei , Li Shaode , Li Zhihan , Zhu Lianqing
Published: August 2023

We designed and fabricated what we believe to be a novel dual-parameter fiber optic sensor for simultaneous measurement of temperature and strain, which was composed of a femtosecond laser inscribed fiber Bragg grating (FBG), three segments of a single-mode fiber (SMF), and two segments of a multimode fiber (MMF), forming a SMF-MMF-FBG-MMF-SMF structure. The FBG and Mach–Zehnder interferometer (MZI) were present in this structure so that the changes of the temperature and strain parameters can be sensed by the shifts of the reflection center wavelength of the FBG and the interference valley wavelength of the MZI. We simulated the light field distribution of the sensor structure, compared the shapes of the interference spectra formed by the MZI structure with different sensing arm lengths of 25, 35, and 45 mm, and analyzed the spectra in the spatial frequency domain. The simulation results showed that the interference spectrum of the MZI structure with a 25 mm length sensing arm was clearer and more suitable for the experiment. The experimental results showed that the temperature sensitivity of the FBG and MZI was 14.81 and 43.54 pm/°C in the range of 80°C to 240°C, and the strain sensitivity was 1.49 and −2.58 pm/µε in the range of 0 to 1200 µε, with a high linearity and excellent repeatability. The sensor is economical, sensitive, and convenient to fabricate, and exhibits promising applications in the fields of biochemical medical detection and industrial production monitoring.
Self-heating allows athermal laser diode wavelength control using a thermally insulating sub-mount over a 70 °C range
Authors: McKenna Robert , Corbett Simon , Mickus Dovydas , Murphy Caolan , McDermott Michael , Naimi Sepideh T. , Donegan John F.
Published: August 2023

The wavelength of a single frequency quantum dot distributed feedback (DFB) laser operating in the O-band is athermalised over a 74 °C ambient temperature range. Two techniques are presented, one utilising the laser self-heating for tuning control, the other using a resistive heater. Both techniques show greatly improved power efficiency over conventional wavelength control schemes, and both demonstrate wavelength stability of better than 0.1 nm (17.5 GHz) without mode hops over the entire temperature range. The use of a high operating temperature quantum dot laser together with an innovative submount design to increase the thermal impedance of the device enables the improved use of the laser self-heating for wavelength tuning. The submount design entails the laser being suspended over an air gap with the use of glass supports, preventing heat from escaping from the diode.