bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring non-commutativity as a perturbation in the Schwarzschild black hole: quasinormal modes, scattering, and shadows
Authors: Heidari N. , Hassanabadi H. , Filho A. A. Araújo , Kr̆íz̆ J.
Published: June 2024

In this work, by a novel approach to studying the scattering of a Schwarzschild black hole, the non-commutativity is introduced as perturbation. We begin by reformulating the Klein–Gordon equation for the scalar field in a new form that takes into account the deformed non-commutative spacetime. Using this formulation, an effective potential for the scattering process is derived. To calculate the quasinormal modes, we employ the WKB method and also utilize fitting techniques to investigate the impact of non-commutativity on the scalar quasinormal modes. We thoroughly analyze the results obtained from these different methods. Moreover, the greybody factor and absorption cross section are investigated. Additionally, we explore the behavior of null geodesics in the presence of non-commutativity. Specifically, we examine the photonic, and shadow radius as well as the light trajectories for different non-commutative parameters. Therefore, by addressing these various aspects, we aim to provide a comprehensive understanding of the influence of non-commutativity on the scattering of a Schwarzschild-like black hole and its implications for the behavior of scalar fields and light trajectories.
Conjugate extrusion with dextral oblique-slip faulting in SE Tibet: new insights into Oligo-Miocene deformation
Authors: Li Hailong , Zhang Yueqiao , Zhang Guihong , Yin Qihang , Tian Yuntao , Wang Qiangmao , Ren Tianxiang
Published: June 2024

SE Tibet experienced significant deformation during the Late Cenozoic, characterized by clockwise rotation of blocks separated by left-lateral strike-slip faults. Through field surveys, structural analyses and microstructural observations, we identified an early phase of ductile shear zones along three major faults: the Anninghe, Jinhe–Jinghe and Jinpingshan faults. New geochronological and thermochronological data collected from these fault zones and from carbonatites associated with a tear fault between two right-lateral oblique faults provide evidence that this slip occurred before
c.
30 Ma. These findings lead to a new conceptual model suggesting that these north–south-trending right-lateral oblique-slip faults, together with the NW-trending left-lateral strike-slip faults in SE Tibet, form a network of large conjugate fractures. The conjugate fracture system, as a result of north- to NE-trending contraction, had a crucial role in controlling the overall tectonic framework of SE Tibet during the Oligocene. By integrating previous research and combining this with our latest findings, we propose a two-phases evolution model of Cenozoic tectonics in the region of SE Tibet, in which a drastic change in kinematics took place from an early phase (before ∼30 Ma) oblique dextral shearing to a late phase sinistral strike-slip faulting since the Miocene.
Code to Qed, the Project Manager's Guide to Proof Engineering
Authors: Dejon Nicolas , Gaber Chrystel , Grimaud Gilles , Jomaa Narjes
Published: June 2024

Despite growing efforts and encouraging successes in recent decades, fully formally verified projects are still rare in the industrial landscape. The industry often lacks the tools and methodologies to efficiently scale the proof development process. In this work, we give a comprehensible overview of the proof development process for proof developers and project managers. The goal is to support proof developers by rationalizing the proof development process, which currently relies heavily on their intuition and expertise, and by facilitating communication with the management line. To this end, we concentrate on the aspect of proof manufacturing and highlight the most significant sources of proof effort. We propose means to mitigate the latter through proof practices (proof structuring, proof strategies, and proof planning), proof metrics, and tools. Our approach is project-agnostic, independent of specific proof expertise, and computed estimations do not assume prior similar developments. We evaluate our guidelines using a separation kernel undergoing formal verification, driving the proof process in an optimised way. Feedback from a project manager unfamiliar with proof development confirms the benefits of detailed planning of the proof development steps, clear progress communication to the hierarchy line, and alignment with established practices in the software industry.
Advancing Hyperdimensional Computing Based on Trainable Encoding and Adaptive Training for Efficient and Accurate Learning
Authors: Kim Jiseung , Lee Hyunsei , Imani Mohsen , Kim Yeseong
Published: June 2024

Hyperdimensional computing (HDC) is a computing paradigm inspired by the mechanisms of human memory, characterizing data through high-dimensional vector representations, known as hypervectors. Recent advancements in HDC have explored its potential as a learning model, leveraging its straightforward arithmetic and high efficiency. The traditional HDC frameworks are hampered by two primary static elements: randomly generated encoders and fixed learning rates. These static components significantly limit model adaptability and accuracy. The static, randomly generated encoders, while ensuring high-dimensional representation, fail to adapt to evolving data relationships, thereby constraining the model’s ability to accurately capture and learn from complex patterns. Similarly, the fixed nature of the learning rate does not account for the varying needs of the training process over time, hindering efficient convergence and optimal performance. This article introducesTrainableHD, a novel HDC framework that enables dynamic training of the randomly generated encoder depending on the feedback of the learning data, thereby addressing the static nature of conventional HDC encoders.TrainableHDalso enhances the training performance by incorporating adaptive optimizer algorithms in learning the hypervectors. We further refineTrainableHDwith effective quantization to enhance efficiency, allowing the execution of the inference phase in low-precision accelerators. Our evaluations demonstrate thatTrainableHDsignificantly improves HDC accuracy by up to 27.99% (averaging 7.02%) without additional computational costs during inference, achieving a performance level comparable to state-of-the-art deep learning models. Furthermore,TrainableHDis optimized for execution speed and energy efficiency. Compared to deep learning on a low-power GPU platform like NVIDIA Jetson Xavier,TrainableHDis 56.4 times faster and 73 times more energy efficient. This efficiency is further augmented through the use of Encoder Interval Training (EIT) and adaptive optimizer algorithms, enhancing the training process without compromising the model’s accuracy.
ENHANCE: Multilevel Heterogeneous Performance-Aware Re-Partitioning Algorithm For Microscopic Vehicle Traffic Simulation
Authors: Siguenza-Torres Anibal , Wieder Alexander , Meng Zhuoxiao , Narvaez Rivas Santiago , Gao Mingyue , Grossi Margherita , Du Xiaorui , Bortoli Stefano , Cai Wentong , Knoll Alois
Published: June 2024

Driven by our work on a large-scale distributed microscopic road traffic simulator, we present ENHANCE, a novel re-partitioning approach that allows incorporating fine-grained simulator-specific cost models into the partitioning process to account for the actual performance characteristics of the simulator.

The use of explicit cost models enables partitioning for heterogeneous resources, which are a common occurrence in cloud deployments. Importantly, ENHANCE can be used in conjunction with other partitioning approaches by further
enhancing
partitions according to provided cost models. We demonstrate the benefits of our approach in an experimental evaluation showing performance improvements of up to 29% against METIS under heterogeneous conditions. Taking a different perspective, the partitioning produced by ENHANCE can provide similar performance as METIS, but using up to 20% fewer resources.
In Situ and 2D and 3D in Silico Redox Cycling Studies for Design Optimization of Coplanar Arrays of Microband Electrodes in a 70 μm × 100 μm Electroactive Footprint
Authors: Abrego Tello Miguel A. , Lotfi Marchoubeh Mahsa , Fritsch Ingrid
Published: June 2024

Optimization of redox-cycling currents was performed by adjusting the height (sidewalls, h), width (w), and length (l) of band electrodes and their spacing (w
gap) in coplanar arrays restricted to a small-electroactive window of 70 × 100 μm. These arrays can function in μL-volumes for chemical analysis (e.g., in-vivo dopamine detection using probes). Experiments were conducted with an array of five electrodes (N

E
= 5), w = 4.3 μm, w
gap = 3.7 μm, h = 0.150 μm, and l = 99.2 μm. Reasons for disparities between currents from experiments and approximate equations were determined by high-density mesh simulations and were found to arise from sluggish heterogeneous electron transfer kinetics and diffusion at electrode ends, edges, and heights. Ferricyanide, with its moderately slow kinetics, exhibits redox-cycling currents that fall below predictions by the equations as w
gap decreases and diffusional flux outpaces reaction rates. Simulations aid investigations of various array designs, achievable through conventional photolithography, by decreasing w and w
gap and increasing N

E
to fit within the electroactive window. A coplanar array, N

E
= 58, w = w
gap = 0.6 μm, h = 0.150 μm and l = 100 μm, yielded ferricyanide sensitivities of 0.266, 0.259 nA·μM−1, enhancements of 8 × and 9 × over w = w
gap = 4 μm, and projected dopamine lower limits of quantitation of 139 nM, 171 nM at generator and collector electrodes, respectively.
Fast on-Site and Highly Sensitive Determination of Allura Red Using a Portable Electrochemical Platform Based on Poly(pyrrole) and Bimetallic Nanocomposites Anchored on Reduced Graphene Oxide
Authors: Georgescu-State Ramona , van Staden Jacobus (Koos) Frederick , Stefan-van Staden Raluca-Ioana , State Razvan Nicolae , Papa Florica
Published: June 2024

Allura red (AR) is classified as an azo dye and is often used as a beverage and food additive. Nevertheless, the need for dose management of Allura red becomes especially important owing to the potential damage caused by the azo structure to the human body and the environment. In order to combat these problems, a novel portable electrochemical platform using a screen-printed carbon electrode (SPCE) that has been modified with poly(pyrrole) and Co-Ni bimetallic nanocomposites anchored on reduced graphene oxide (Co-Ni@rGO) was developed. The purpose of this platform is to enable rapid on-site and very sensitive determination of Allura red from carbonated energy beverages and water samples. Under ideal experimental conditions, the proposed platform’s response exhibits a notable linear relationship with the concentration of Allura red within the range of 0.0001–10 μM, having a very low limit of detection (LOD) of 0.03 nM and a high sensitivity of 24.62 μA μM−1 cm−2. Furthermore, the PPy/Co-Ni@rGO/SPCE platform exhibited favorable characteristics in terms of reproducibility, repeatability, stability, and selectivity for the quantification of Allura red. Consequently, the developed platform was capable of practically and effectively determining the Allura red dye content from various real samples, showing satisfactory recovery rates.
One-Pot Electrodeposition of a PANI:PSS/MWCNT Nanocomposite on Carbon Paper for Scalable Determination of Ascorbic Acid
Authors: Robertson Stuart J. , Cheng Jinping , Shao Minhua
Published: June 2024

In recent years, there has been growing demand for the monitoring of ascorbic acid levels, especially in underdeveloped populations where ascorbic acid deficiency affects up to 74% of individuals. To facilitate widespread ascorbic acid screening, we have developed a highly scalable conductive polymer nanocomposite with excellent ascorbic acid sensing performance. The material is based on polyaniline, which is deposited in a single step in the presence of polystyrene sulfonate and multi-walled carbon nanotubes onto carbon paper. The modified electrodes take advantage of the electrocatalytic properties of polyaniline toward ascorbic acid, which are boosted by the proton donating polystyrene sulfonate polymer and the high surface area of the multi-walled carbon nanotubes. The morphology and composition of the composite are characterized using field-emission scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy and the electrochemical characteristics are examined using cyclic voltammetry and electrochemical impedance spectroscopy. The modified electrode shows good ascorbic acid sensing characteristics, with a linear range of 1–400 μM, a sensitivity of 546 μA mM−1 cm−2, and a limit of detection of 0.11 μM. High performance and low cost results in a promising platform to support the widespread, cheap monitoring of ascorbic acid deficiency.
Novel Hybrid Copper-Based Electrode for Non-Enzymatic Electrochemical Lactic Acid Sensing in Milk Samples
Authors: Ngamaroonchote Aroonsri , Karn-orachai Kullavadee
Published: June 2024

A novel developed non-enzymatic electrochemical sensor was designed for the detection of lactic acid (LA) in perishable products, with a focus on monitoring milk spoilage. The sensor utilizes a hybrid copper-based electrode consisting of cuprous oxide (Cu2O), copper oxide (CuO), and copper hydroxide (Cu(OH)2), which collectively contribute to enhanced performance through their synergistic effects. Cyclic voltammetric studies revealed distinct oxidation peaks associated with LA detection, highlighting the superior catalytic effect of the Cu2O/CuO/Cu(OH)2 electrode compared to CuO alone. Further optimization of the metal loading on the electrode surface led to improve LA sensing properties. The sensor exhibited a wide linear response range (0.25–7 mM), high sensitivity (817.66 μA·mM−1·cm−2), and a low limit of detection (0.25 mM). Selectivity tests indicated negligible interference from common dairy product constituents, while stability tests showed consistent performance over a 3 week storage period (100% stability). The practical usability of the sensor was demonstrated through the quantitative analysis of LA in pasteurized milk, with recovery values ranging from 99.7% to 106.9%, confirming the feasibility of the sensor for real sample analysis. The developed multiphase copper-based electrode presents a promising platform for the sensitive and reliable detection of LA within the dairy industry.
Supplementary Figure S9 from A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer
Authors: Brown Brooke A. , Myers Paul J. , Adair Sara J. , Pitarresi Jason R. , Sah-Teli Shiv K. , Campbell Logan A. , Hart William S. , Barbeau Michelle C. , Leong Kelsey , Seyler Nicholas , Kane William , Lee Kyoung Eun , Stelow Edward , Jones Marieke , Simon M. Celeste , Koivunen Peppi , Bauer Todd W. , Stanger Ben Z. , Lazzara Matthew J.
Published: June 2024

Supplementary Figure S9
Supplementary Figure S3 from A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer
Authors: Brown Brooke A. , Myers Paul J. , Adair Sara J. , Pitarresi Jason R. , Sah-Teli Shiv K. , Campbell Logan A. , Hart William S. , Barbeau Michelle C. , Leong Kelsey , Seyler Nicholas , Kane William , Lee Kyoung Eun , Stelow Edward , Jones Marieke , Simon M. Celeste , Koivunen Peppi , Bauer Todd W. , Stanger Ben Z. , Lazzara Matthew J.
Published: June 2024

Supplementary Figure S3
Supplementary Figure S12 from A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer
Authors: Brown Brooke A. , Myers Paul J. , Adair Sara J. , Pitarresi Jason R. , Sah-Teli Shiv K. , Campbell Logan A. , Hart William S. , Barbeau Michelle C. , Leong Kelsey , Seyler Nicholas , Kane William , Lee Kyoung Eun , Stelow Edward , Jones Marieke , Simon M. Celeste , Koivunen Peppi , Bauer Todd W. , Stanger Ben Z. , Lazzara Matthew J.
Published: June 2024

Supplementary Figure S12
Supplementary Fig. S7 from Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers
Authors: Liao Haotian , Chen Xing , Wang Haichuan , Lin Youpei , Chen Lu , Yuan Kefei , Liao Mingheng , Jiang Hanyu , Peng Jiajie , Wu Zhenru , Huang Jiwei , Li Jiaxin , Zeng Yong
Published: June 2024

Supplementary Fig. S7
Supplementary Fig. S17 from Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers
Authors: Liao Haotian , Chen Xing , Wang Haichuan , Lin Youpei , Chen Lu , Yuan Kefei , Liao Mingheng , Jiang Hanyu , Peng Jiajie , Wu Zhenru , Huang Jiwei , Li Jiaxin , Zeng Yong
Published: June 2024

Supplementary Fig. S17
Supplementary Fig. S13 from Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers
Authors: Liao Haotian , Chen Xing , Wang Haichuan , Lin Youpei , Chen Lu , Yuan Kefei , Liao Mingheng , Jiang Hanyu , Peng Jiajie , Wu Zhenru , Huang Jiwei , Li Jiaxin , Zeng Yong
Published: June 2024

Supplementary Fig. S13
Supplementary Figure S9 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Authors: Boufaied Nadia , Chetta Paolo , Hallal Tarek , Cacciatore Stefano , Lalli Daniela , Luthold Carole , Homsy Kevin , Imada Eddie L. , Syamala Sudeepa , Photopoulos Cornelia , Di Matteo Anna , de Polo Anna , Storaci Alessandra Maria , Huang Ying , Giunchi Francesca , Sheridan Patricia A. , Michelotti Gregory , Nguyen Quang-De , Zhao Xin , Liu Yang , Davicioni Elai , Spratt Daniel E. , Sabbioneda Simone , Maga Giovanni , Mucci Lorelei A. , Ghigna Claudia , Marchionni Luigi , Butler Lisa M. , Ellis Leigh , Bordeleau François , Loda Massimo , Vaira Valentina , Labbé David P. , Zadra Giorgia
Published: June 2024

Supplementary Figure S9 shows GSEA_Hallmark results in human PCa
Supplementary Table S3. Primers and siRNAs from SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma
Authors: Wan Shan , He Quan-Yao , Yang Yun , Liu Feng , Zhang Xue , Guo Xin , Niu Hui , Wang Yi , Liu Yi-Xuan , Ye Wen-Long , Li Xiu-Ming , ZhuanSun Xue-Mei , Sun Pu , He Xiao-Shun , Hu Guang , Breuhahn Kai , Zhao Hua , Wu Guo-Qiang , Wu Hua
Published: June 2024

Supplementary Table S3. Primers and siRNAs
Supplementary Table S2. Antibodies（RRID） from SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma
Authors: Wan Shan , He Quan-Yao , Yang Yun , Liu Feng , Zhang Xue , Guo Xin , Niu Hui , Wang Yi , Liu Yi-Xuan , Ye Wen-Long , Li Xiu-Ming , ZhuanSun Xue-Mei , Sun Pu , He Xiao-Shun , Hu Guang , Breuhahn Kai , Zhao Hua , Wu Guo-Qiang , Wu Hua
Published: June 2024

Supplementary Table S2. Antibodies（RRID）
Supplementary Figure S6 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Authors: Boufaied Nadia , Chetta Paolo , Hallal Tarek , Cacciatore Stefano , Lalli Daniela , Luthold Carole , Homsy Kevin , Imada Eddie L. , Syamala Sudeepa , Photopoulos Cornelia , Di Matteo Anna , de Polo Anna , Storaci Alessandra Maria , Huang Ying , Giunchi Francesca , Sheridan Patricia A. , Michelotti Gregory , Nguyen Quang-De , Zhao Xin , Liu Yang , Davicioni Elai , Spratt Daniel E. , Sabbioneda Simone , Maga Giovanni , Mucci Lorelei A. , Ghigna Claudia , Marchionni Luigi , Butler Lisa M. , Ellis Leigh , Bordeleau François , Loda Massimo , Vaira Valentina , Labbé David P. , Zadra Giorgia
Published: June 2024

Supplementary Figure S6 includes scRNA-seq data showing that Luminal (high Ly6d) cells in MYC-transformed DLP display glycolytic features.
Supplementary Figure 4 from SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma
Authors: Wan Shan , He Quan-Yao , Yang Yun , Liu Feng , Zhang Xue , Guo Xin , Niu Hui , Wang Yi , Liu Yi-Xuan , Ye Wen-Long , Li Xiu-Ming , ZhuanSun Xue-Mei , Sun Pu , He Xiao-Shun , Hu Guang , Breuhahn Kai , Zhao Hua , Wu Guo-Qiang , Wu Hua
Published: June 2024

SPARC mediates AKT signaling activation via cholesterol.
Supplementary Figure 3 from SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma
Authors: Wan Shan , He Quan-Yao , Yang Yun , Liu Feng , Zhang Xue , Guo Xin , Niu Hui , Wang Yi , Liu Yi-Xuan , Ye Wen-Long , Li Xiu-Ming , ZhuanSun Xue-Mei , Sun Pu , He Xiao-Shun , Hu Guang , Breuhahn Kai , Zhao Hua , Wu Guo-Qiang , Wu Hua
Published: June 2024

Binding domains of ApoE and TRIM21 proteins.
Supplementary Figure S3 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Authors: Boufaied Nadia , Chetta Paolo , Hallal Tarek , Cacciatore Stefano , Lalli Daniela , Luthold Carole , Homsy Kevin , Imada Eddie L. , Syamala Sudeepa , Photopoulos Cornelia , Di Matteo Anna , de Polo Anna , Storaci Alessandra Maria , Huang Ying , Giunchi Francesca , Sheridan Patricia A. , Michelotti Gregory , Nguyen Quang-De , Zhao Xin , Liu Yang , Davicioni Elai , Spratt Daniel E. , Sabbioneda Simone , Maga Giovanni , Mucci Lorelei A. , Ghigna Claudia , Marchionni Luigi , Butler Lisa M. , Ellis Leigh , Bordeleau François , Loda Massimo , Vaira Valentina , Labbé David P. , Zadra Giorgia
Published: June 2024

Supplementary Figure S3 shows a graphical representation of key metabolic pathways altered by MYC alone or by obesogenic HFD in WT and MYC-transformed DLP.
Supplementary Figure S10 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Authors: Boufaied Nadia , Chetta Paolo , Hallal Tarek , Cacciatore Stefano , Lalli Daniela , Luthold Carole , Homsy Kevin , Imada Eddie L. , Syamala Sudeepa , Photopoulos Cornelia , Di Matteo Anna , de Polo Anna , Storaci Alessandra Maria , Huang Ying , Giunchi Francesca , Sheridan Patricia A. , Michelotti Gregory , Nguyen Quang-De , Zhao Xin , Liu Yang , Davicioni Elai , Spratt Daniel E. , Sabbioneda Simone , Maga Giovanni , Mucci Lorelei A. , Ghigna Claudia , Marchionni Luigi , Butler Lisa M. , Ellis Leigh , Bordeleau François , Loda Massimo , Vaira Valentina , Labbé David P. , Zadra Giorgia
Published: June 2024

Supplementary Figure S10 shows the output of human-based deconvolution model QuanTIseq.
Supplementary Figure S1 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Authors: Boufaied Nadia , Chetta Paolo , Hallal Tarek , Cacciatore Stefano , Lalli Daniela , Luthold Carole , Homsy Kevin , Imada Eddie L. , Syamala Sudeepa , Photopoulos Cornelia , Di Matteo Anna , de Polo Anna , Storaci Alessandra Maria , Huang Ying , Giunchi Francesca , Sheridan Patricia A. , Michelotti Gregory , Nguyen Quang-De , Zhao Xin , Liu Yang , Davicioni Elai , Spratt Daniel E. , Sabbioneda Simone , Maga Giovanni , Mucci Lorelei A. , Ghigna Claudia , Marchionni Luigi , Butler Lisa M. , Ellis Leigh , Bordeleau François , Loda Massimo , Vaira Valentina , Labbé David P. , Zadra Giorgia
Published: June 2024

Supplementary Figure S1 shows the systemic effects of HFD.
Supplementary Table S6 from The Deep Learning Framework iCanTCR Enables Early Cancer Detection Using the T-cell Receptor Repertoire in Peripheral Blood
Authors: Cai Yideng , Luo Meng , Yang Wenyi , Xu Chang , Wang Pingping , Xue Guangfu , Jin Xiyun , Cheng Rui , Que Jinhao , Zhou Wenyang , Pang Boran , Xu Shouping , Li Yu , Jiang Qinghua , Xu Zhaochun
Published: June 2024

Results of iCanTCR performance to detect three early-stage cancer types using PBMC TCR repertoire
Supplementary Tables from A Subpopulation of Luminal Progenitors Secretes Pleiotrophin to Promote Angiogenesis and Metastasis in Inflammatory Breast Cancer
Authors: Zhang Mengmeng , Zhou Kaiwen , Wang Zilin , Liu Ting , Stevens Laura E. , Lynce Filipa , Chen Wendy Y. , Peng Sui , Xie Yubin , Zhai Duanyang , Chen Qianjun , Shi Yawei , Shi Huijuan , Yuan Zhongyu , Li Xiaoping , Xu Juan , Cai Zhenhai , Guo Jianping , Shao Nan , Lin Ying
Published: June 2024

All supplementary tables in one excel file
Supplementary materials and methods from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy
Authors: Weng Jialei , Wang Zheng , Hu Zhiqiu , Xu Wenxin , Sun Jia-Lei , Wang Fu , Zhou Qiang , Liu Shaoqing , Xu Min , Xu Minghao , Gao Dongmei , Shen Ying-Hao , Yi Yong , Shi Yi , Dong Qiongzhu , Zhou Chenhao , Ren Ning
Published: June 2024

Supplementary materials and methods
Figure 1 from Oncogenic Cell Tagging and Single-Cell Transcriptomics Reveal Cell Type–Specific and Time-Resolved Responses to Vhl Inactivation in the Kidney
Authors: Kurlekar Samvid , Lima Joanna D.C.C. , Li Ran , Lombardi Olivia , Masson Norma , Barros Ayslan B. , Pontecorvi Virginia , Mole David R. , Pugh Christopher W. , Adam Julie , Ratcliffe Peter J.
Published: June 2024

A novel reporter model for Vhl inactivation in the mouse kidney. A, Design and recombination of the cell marking conditional Vhlpjr allele. Double and single arrows indicate reversible and irreversible processes, respectively. Vhlpjr.fl, Vhlpjr.inrec, and Vhlpjr.KO refer to “floxed,” “incompletely recombined,” and “knockout” forms of the Vhlpjr allele. P, Vhl promoter; U, untranslated region; E, Vhl exon; I, Vhl intron; pA, polyadenylation site; P2A, porcine teschovirus 2A peptide; SA, splice acceptor. Dashed lines, spliced and translated regions; lightning symbols, excitation and emission wavelengths for tdTomato fluorescence. Red stop sign indicates no interaction between VHL exon 1 fragment and HIFA-1/2 or Elongin B/C. B, Representative tdTomato IHC counterstained with hematoxylin in kidney sections and tdTomato fluorescence-based flow cytometry on renal cells from Vhlwt/pjr.fl; Pax8-CreERT2 mice untreated (top) or given 5 × 2 mg tamoxifen (TMX; bottom) and harvested at the early time point. Scale bar, 250 μm. Magnification, ×20. FACS gates are shown. C, Gel electrophoresis of genomic PCR for Vhlwt, Vhlpjr.fl, and Vhlpjr.KO alleles performed on FAC-sorted tdTomato-positive (left) or tdTomato-negative (right) cells from kidneys of Vhlwt/pjr.fl; Pax8-CreERT2 mice given tamoxifen and harvested at the early time point. D, Representative immunoblots (IB) for HIF1A, HIF2A, or tdTomato protein in tdTomato-negative (−) or tdTomato-positive (+) cells sorted by flow cytometry from dissociated kidneys of Vhljae.KO/pjr.fl or Vhlwt/pjr.fl Pax8-CreERT2 mice given 5 × 2 mg tamoxifen and harvested at the early time point (n = 3 per genotype).
Supplementary Figure S8 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy
Authors: Weng Jialei , Wang Zheng , Hu Zhiqiu , Xu Wenxin , Sun Jia-Lei , Wang Fu , Zhou Qiang , Liu Shaoqing , Xu Min , Xu Minghao , Gao Dongmei , Shen Ying-Hao , Yi Yong , Shi Yi , Dong Qiongzhu , Zhou Chenhao , Ren Ning
Published: June 2024

(A) Representative IHC staining images showing the expressions of SLAMF7 and CCL2 in HCC samples. Scale bar: 200 μm (left) and 20 μm (right). (B) The prognostic prediction performances of SLAMF7 in combination with CCL2 for OS and DFS in our Fudan LCI HCC cohort.
Supplementary Figure S7 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy
Authors: Weng Jialei , Wang Zheng , Hu Zhiqiu , Xu Wenxin , Sun Jia-Lei , Wang Fu , Zhou Qiang , Liu Shaoqing , Xu Min , Xu Minghao , Gao Dongmei , Shen Ying-Hao , Yi Yong , Shi Yi , Dong Qiongzhu , Zhou Chenhao , Ren Ning
Published: June 2024

(A-B) qPCR and ELISA analyses of CCL2 transcriptional and secretory levels in the indicated HCC cells. (C-D) Flow cytometry analysis of CD80 and CD206 expressions in THP-1-differentiated macrophages cocultured with the indicated HCC cells in the presence of recombinant CCL2 protein or CCL2 neutralizing antibody. (E-F) Chemotaxis assays showing the effect of CCL2 signaling on SLAMF7-regulated migration of macrophages using the indicated treatments. (G) Left: Gross appearance of the liver bearing orthotopic HCC tumors in the indicated treatment groups. Right: The tumor weight and tumor volume of each group (5 mice per group). (H) Flow cytometry assays of tumor infiltration proportions of CD11b+ F4/80+ MHC-II+ macrophages and CD11b+ F4/80+ CD206+ macrophages in the indicated treatment groups. *P<0.05, **P<0.01, and ***P<0.001, One-way ANOVA with a post hoc LSD test (or Student’s t test in part A-B). Experiments were repeated three time and results were present as the mean ± SD.
Supplementary Figure S5 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy
Authors: Weng Jialei , Wang Zheng , Hu Zhiqiu , Xu Wenxin , Sun Jia-Lei , Wang Fu , Zhou Qiang , Liu Shaoqing , Xu Min , Xu Minghao , Gao Dongmei , Shen Ying-Hao , Yi Yong , Shi Yi , Dong Qiongzhu , Zhou Chenhao , Ren Ning
Published: June 2024

(A) Top: Schematic showing the administration schedule of clophosome in the indicated orthotopic HCC mouse models. Bottom: Gross appearance of the liver bearing Hepa1-6 tumors in the indicated treatment groups. (B) The tumor weight and tumor volume of each group at the study endpoint (5 mice per group). NS, not significant, **P<0.01, and ***P<0.001, one-way ANOVA with a post hoc LSD test.
Supplementary Figure S10 from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy
Authors: Weng Jialei , Wang Zheng , Hu Zhiqiu , Xu Wenxin , Sun Jia-Lei , Wang Fu , Zhou Qiang , Liu Shaoqing , Xu Min , Xu Minghao , Gao Dongmei , Shen Ying-Hao , Yi Yong , Shi Yi , Dong Qiongzhu , Zhou Chenhao , Ren Ning
Published: June 2024

(A) Immunoblot assay of SHB protein level in the indicated HCC cells. (B-C) Immunoblot assays of phosphorylated and non-phosphorylated SHIP1, and K63-linked ubiquitinated TRAF6 level in the indicated HCC cells with and without SHB silence.
Table S9 from Cigarette Smoking and E-cigarette Use Induce Shared DNA Methylation Changes Linked to Carcinogenesis
Authors: Herzog Chiara , Jones Allison , Evans Iona , Raut Janhavi R. , Zikan Michal , Cibula David , Wong Andrew , Brenner Hermann , Richmond Rebecca C. , Widschwendter Martin
Published: June 2024

Supplementary Table 9
Table S5 from Cigarette Smoking and E-cigarette Use Induce Shared DNA Methylation Changes Linked to Carcinogenesis
Authors: Herzog Chiara , Jones Allison , Evans Iona , Raut Janhavi R. , Zikan Michal , Cibula David , Wong Andrew , Brenner Hermann , Richmond Rebecca C. , Widschwendter Martin
Published: June 2024

Supplementary Table 5
Table S10 from Cigarette Smoking and E-cigarette Use Induce Shared DNA Methylation Changes Linked to Carcinogenesis
Authors: Herzog Chiara , Jones Allison , Evans Iona , Raut Janhavi R. , Zikan Michal , Cibula David , Wong Andrew , Brenner Hermann , Richmond Rebecca C. , Widschwendter Martin
Published: June 2024

Supplementary Table 10
Figure 6 from Cigarette Smoking and E-cigarette Use Induce Shared DNA Methylation Changes Linked to Carcinogenesis
Authors: Herzog Chiara , Jones Allison , Evans Iona , Raut Janhavi R. , Zikan Michal , Cibula David , Wong Andrew , Brenner Hermann , Richmond Rebecca C. , Widschwendter Martin
Published: June 2024

Prediction of lung cancer using immune hypoM in blood and proximal epithelial hyperM in buccal samples compared with previously described predictors. A, Comparison of the AUCs of AHRR (cg05575921), F2RL3 (cg03636183), and mean methylation at immune hypoM to identify any lung cancer cases within 17 years in 259 current smokers in the ESTHER study. B, Comparison of the AUCs of AHRR (cg05575921), F2RL3 (cg03636183), and mean methylation at immune hypoM (corrected for immune cell proportion) to identify any lung or airway cancer cases within 22 years in 31 blood samples (n = 6 cancer cases) of the validation set (same individuals as in C). C, Comparison of the AUCs of AHRR (cg05575921), F2RL3 (cg03636183), and mean methylation at proximal epithelial hyperM (corrected for immune cell proportion) to identify any lung or airway cancer cases within 22 years in 31 buccal samples (n = 6 cancer cases) of the validation set (same individuals as in B).
Data from The Deep Learning Framework iCanTCR Enables Early Cancer Detection Using the T-cell Receptor Repertoire in Peripheral Blood
Authors: Cai Yideng , Luo Meng , Yang Wenyi , Xu Chang , Wang Pingping , Xue Guangfu , Jin Xiyun , Cheng Rui , Que Jinhao , Zhou Wenyang , Pang Boran , Xu Shouping , Li Yu , Jiang Qinghua , Xu Zhaochun
Published: June 2024

Abstract
T cells recognize tumor antigens and initiate an anticancer immune response in the very early stages of tumor development, and the antigen specificity of T cells is determined by the T-cell receptor (TCR). Therefore, monitoring changes in the TCR repertoire in peripheral blood may offer a strategy to detect various cancers at a relatively early stage. Here, we developed the deep learning framework iCanTCR to identify patients with cancer based on the TCR repertoire. The iCanTCR framework uses TCRβ sequences from an individual as an input and outputs the predicted cancer probability. The model was trained on over 2,000 publicly available TCR repertoires from 11 types of cancer and healthy controls. Analysis of several additional publicly available datasets validated the ability of iCanTCR to distinguish patients with cancer from noncancer individuals and demonstrated the capability of iCanTCR for the accurate classification of multiple cancers. Importantly, iCanTCR precisely identified individuals with early-stage cancer with an AUC of 86%. Altogether, this work provides a liquid biopsy approach to capture immune signals from peripheral blood for noninvasive cancer diagnosis.
Significance:
Development of a deep learning–based method for multicancer detection using the TCR repertoire in the peripheral blood establishes the potential of evaluating circulating immune signals for noninvasive early cancer detection.
Data from Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy
Authors: Weng Jialei , Wang Zheng , Hu Zhiqiu , Xu Wenxin , Sun Jia-Lei , Wang Fu , Zhou Qiang , Liu Shaoqing , Xu Min , Xu Minghao , Gao Dongmei , Shen Ying-Hao , Yi Yong , Shi Yi , Dong Qiongzhu , Zhou Chenhao , Ren Ning
Published: June 2024

Abstract
Immune checkpoint inhibitors have limited efficacy in hepatocellular carcinoma (HCC). Macrophages are the most abundant immune cells in HCC, suggesting that a better understanding of the intrinsic processes by which tumor cells regulate macrophages could help identify strategies to improve response to immunotherapy. As signaling lymphocytic activation molecule (SLAM) family members regulate various immune functions, we investigated the role of specific SLAM receptors in the immunobiology of HCC. Comparison of the transcriptomic landscapes of immunotherapy-responsive and nonresponsive patients with advanced HCC identified SLAMF7 upregulation in immunotherapy-responsive HCC, and patients with HCC who responded to immunotherapy also displayed higher serum levels of SLAMF7. Loss of Slamf7 in liver-specific knockout mice led to increased hepatocarcinogenesis and metastasis, elevated immunosuppressive macrophage infiltration, and upregulated PD-1 expression in CD8+ T cells. HCC cell-intrinsic SLAMF7 suppressed MAPK/ATF2-mediated CCL2 expression to regulate macrophage migration and polarization in vitro. Mechanistically, SLAMF7 associated with SH2 domain-containing adaptor protein B (SHB) through its cytoplasmic 304 tyrosine site to facilitate the recruitment of SHIP1 to SLAMF7 and inhibit the ubiquitination of TRAF6, thereby attenuating MAPK pathway activation and CCL2 transcription. Pharmacological antagonism of the CCL2/CCR2 axis potentiated the therapeutic effect of anti–PD-1 antibody in orthotopic HCC mouse models with low SLAMF7 expression. In conclusion, this study highlights SLAMF7 as a regulator of macrophage function and a potential predictive biomarker of immunotherapy response in HCC. Strategies targeting CCL2 signaling to induce macrophage repolarization in HCC with low SLAMF7 might enhance the efficacy of immunotherapy.
Significance:
CCL2 upregulation caused by SLAMF7 deficiency in hepatocellular carcinoma cells induces immunosuppressive macrophage polarization and confers resistance to immune checkpoint blockade, providing potential biomarkers and targets to improve immunotherapy response in patients.
Diet and Tumor Genetics Conspire to Promote Prostate Cancer Metabolism and Shape the Tumor Microenvironment
Authors: Frigo Daniel E.
Published: June 2024

Obesity has been linked to prostate cancer in a stage-dependent manner, having no association with cancer initiation but correlating with disease progression in men with prostate cancer. Given the rising obesity rate and its association to aggressive prostate cancer, there is a growing need to understand the mechanisms underlying this relationship to identify patients at increased risk of lethal disease and inform therapeutic approaches. In this issue of Cancer Research, Boufaied and colleagues describe how diets high in saturated fatty acids promote MYC-driven prostate cancer. Leveraging MYC-expressing genetically engineered and allograft mouse models fed either a control low-fat or high-fat diet (HFD) enriched in saturated fatty acids, the authors found using digital pathology that HFD-fed mice exhibited increased tumor invasion. Metabolomics, transcriptomics, immunoblotting, and positron emission tomography of tumors from these mice demonstrated that a HFD promoted a metabolic shift in the tumors towards glycolysis. These preclinical data were supported by findings from two large clinical cohorts revealing that men diagnosed with prostate cancer and who consumed high levels of saturated fatty acids possessed tumors bearing glycolytic signatures. Deconvolution analyses and immunohistochemistry validation showed that these tumors also displayed increased angiogenesis and infiltration of immunosuppressive macrophages and regulatory T cells, the latter of which was also correlated with high saturated fat intake–associated glycolytic signatures in patient tumors. Together, these findings suggest that diets rich in saturated fatty acids, rather than obesity alone, accelerate MYC-driven prostate cancers through shifting tumor metabolism and shaping the tumor microenvironment.

See related article by Boufaied et al., p. 1834
Supplementary Materials and Methods from Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus
Authors: Chang Chun-Ping , Yeh Teng-Kuang , Chen Chiung-Tong , Wang Wan-Ping , Chen Yen-Ting , Tsai Chia-Hua , Chen Yan-Fu , Ke Yi-Yu , Wang Jing-Ya , Chen Ching-Ping , Hsieh Tsung-Chih , Wu Mine-Hsine , Huang Chen-Lung , Chen Ya-Ping , Zhuang Hong , Chi Ya-Hui
Published: June 2024

Supplementary Methods
Supplementary Figure 5 from Patient-Derived Tumor Xenograft Study with CDK4/6 Inhibitor Plus AKT Inhibitor for the Management of Metastatic Castration-Resistant Prostate Cancer
Authors: Kase Adam M. , Gleba Justyna , Miller James L. , Miller Erin , Petit Joachim , Barrett Michael T. , Zhou Yumei , Parent Ephraim E. , Cai Hancheng , Knight Joshua A. , Orme Jacob , Reynolds Jordan , Durham William F. , Metz Thomas M. , Meurice Nathalie , Edenfield Brandy , Alasonyalilar Demirer Aylin , Bilgili Ahmet , Hickman Peyton G. , Pawlush Matthew L. , Marlow Laura , Wickland Daniel P. , Tan Winston , Copland John A.
Published: June 2024

Supplementary Figure 5
Supplementary Figure S8 from Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus
Authors: Chang Chun-Ping , Yeh Teng-Kuang , Chen Chiung-Tong , Wang Wan-Ping , Chen Yen-Ting , Tsai Chia-Hua , Chen Yan-Fu , Ke Yi-Yu , Wang Jing-Ya , Chen Ching-Ping , Hsieh Tsung-Chih , Wu Mine-Hsine , Huang Chen-Lung , Chen Ya-Ping , Zhuang Hong , Chi Ya-Hui
Published: June 2024

Supplementary Figure S8. Tissue distribution of DBPR728 and its active moiety 6K465. LC-MS/MS quantification for the concentrations of DBPR728 and 6K465 in tissues (plasma, heart, aorta, liver, lung and kidney) of ICR mice (n = 7) after 24 hr of taking one 300 mpk dose of DBPR728. Errors are mean ± SD.
Supplementary Figure 2 from Patient-Derived Tumor Xenograft Study with CDK4/6 Inhibitor Plus AKT Inhibitor for the Management of Metastatic Castration-Resistant Prostate Cancer
Authors: Kase Adam M. , Gleba Justyna , Miller James L. , Miller Erin , Petit Joachim , Barrett Michael T. , Zhou Yumei , Parent Ephraim E. , Cai Hancheng , Knight Joshua A. , Orme Jacob , Reynolds Jordan , Durham William F. , Metz Thomas M. , Meurice Nathalie , Edenfield Brandy , Alasonyalilar Demirer Aylin , Bilgili Ahmet , Hickman Peyton G. , Pawlush Matthew L. , Marlow Laura , Wickland Daniel P. , Tan Winston , Copland John A.
Published: June 2024

Supplementary Figure 2
Supplementary Figure S4 from Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus
Authors: Chang Chun-Ping , Yeh Teng-Kuang , Chen Chiung-Tong , Wang Wan-Ping , Chen Yen-Ting , Tsai Chia-Hua , Chen Yan-Fu , Ke Yi-Yu , Wang Jing-Ya , Chen Ching-Ping , Hsieh Tsung-Chih , Wu Mine-Hsine , Huang Chen-Lung , Chen Ya-Ping , Zhuang Hong , Chi Ya-Hui
Published: June 2024

Supplementary Figure S4. DBPR728 induces consecutive cell apoptosis. (A) Quantification of the pH3Ser10 and NEUROD1 levels in the xenografts measured by Western analysis (Fig. 4B). Errors are mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (t-test, two-tailed). (B) Immunohistochemical analysis for the expression of cleaved Caspase-3 to mark apoptotic cells in NCI-H446 tumor xenografts harvested from mice described in Fig. 4A.
Table S4 from A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors
Authors: Gilmer Tona M. , Lai Chun-Hsiang , Guo Kexiao , Deland Katherine , Ashcraft Kathleen A. , Stewart Amy E. , Wang Yaode , Fu Jianmin , Wood Kris C. , Kirsch David G. , Kastan Michael B.
Published: June 2024

MDA-MB-231 clonogenic survival treated with XRD-0394
Table S3 from A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors
Authors: Gilmer Tona M. , Lai Chun-Hsiang , Guo Kexiao , Deland Katherine , Ashcraft Kathleen A. , Stewart Amy E. , Wang Yaode , Fu Jianmin , Wood Kris C. , Kirsch David G. , Kastan Michael B.
Published: June 2024

FaDu clonogenic survival treated with XRD-0394
Figure S1 from A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors
Authors: Gilmer Tona M. , Lai Chun-Hsiang , Guo Kexiao , Deland Katherine , Ashcraft Kathleen A. , Stewart Amy E. , Wang Yaode , Fu Jianmin , Wood Kris C. , Kirsch David G. , Kastan Michael B.
Published: June 2024

Western blots
CRISPR screen from A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors
Authors: Gilmer Tona M. , Lai Chun-Hsiang , Guo Kexiao , Deland Katherine , Ashcraft Kathleen A. , Stewart Amy E. , Wang Yaode , Fu Jianmin , Wood Kris C. , Kirsch David G. , Kastan Michael B.
Published: June 2024

MAGeCK-Analysis
Supplemental Table S6 from Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer
Authors: Wallace-Povirk Adrianne , O'Connor Carrie , Dekhne Aamod S. , Bao Xun , Nayeen Md. Junayed , Schneider Mathew , Katinas Jade M. , Wong-Roushar Jennifer , Kim Seongho , Polin Lisa , Li Jing , Back Jessica B. , Dann Charles E. , Gangjee Aleem , Hou Zhanjun , Matherly Larry H.
Published: June 2024

This table shows Kis for inhibition of one-carbon enzymes for 5-substituted pyrrolo[3,2-
d]pyrimidine antifolates.
Supplemental Table S5 from Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer
Authors: Wallace-Povirk Adrianne , O'Connor Carrie , Dekhne Aamod S. , Bao Xun , Nayeen Md. Junayed , Schneider Mathew , Katinas Jade M. , Wong-Roushar Jennifer , Kim Seongho , Polin Lisa , Li Jing , Back Jessica B. , Dann Charles E. , Gangjee Aleem , Hou Zhanjun , Matherly Larry H.
Published: June 2024

This table shows purity of Subcellular Fractions.
Supplemental Table S3 from Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer
Authors: Wallace-Povirk Adrianne , O'Connor Carrie , Dekhne Aamod S. , Bao Xun , Nayeen Md. Junayed , Schneider Mathew , Katinas Jade M. , Wong-Roushar Jennifer , Kim Seongho , Polin Lisa , Li Jing , Back Jessica B. , Dann Charles E. , Gangjee Aleem , Hou Zhanjun , Matherly Larry H.
Published: June 2024

This table shows information of epithelial ovarian cancer tissue microarray (TMA) for immunohistochemistry.
Figure S6 from Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer
Authors: Chowdhury Priyanka , Velalopoulou Anastasia , Verginadis Ioannis I. , Morcos George , Loo Phoebe E. , Kim Michele M. , Motlagh Seyyedeh Azar Oliaei , Shoniyozov Khayrullo , Diffenderfer Eric S. , Ocampo Emilio A. , Putt Mary , Assenmacher Charles-Antoine , Radaelli Enrico , Lu Jiawei , Qin Ling , Liu Hengxi , Leli Nektaria Maria , Girdhani Swati , Denef Nicolas , Vander Stappen Francois , Cengel Keith A. , Busch Theresa M. , Metz James M. , Dong Lei , Lin Alexander , Koumenis Constantinos
Published: June 2024

F-PRT reduces radiation-induced damage to the oral cavity compared to S-PRT.
Supplementary Table 6 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer
Authors: Neeb Antje , Figueiredo Ines , Bogdan Denisa , Cato Laura , Stober Jutta , Jiménez-Vacas Juan M. , Gourain Victor , Lee Irene I. , Seeger Rebecca , Muhle-Goll Claudia , Gurel Bora , Welti Jonathan , Nava Rodrigues Daniel , Rekowski Jan , Qiu Xintao , Jiang Yija , Di Micco Patrizio , Mateos Borja , Bielskutė Stasė , Riisnaes Ruth , Ferreira Ana , Miranda Susana , Crespo Mateus , Buroni Lorenzo , Ning Jian , Carreira Suzanne , Bräse Stefan , Jung Nicole , Gräßle Simone , Swain Amanda , Salvatella Xavier , Plymate Stephen R. , Al-Lazikani Bissan , Long Henry W. , Yuan Wei , Brown Myles , Cato Andrew C.B. , de Bono Johann S. , Sharp Adam
Published: June 2024

ON-TARGETplus siRNA pools for gene expression knockdown.
Supplementary Table 4 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer
Authors: Neeb Antje , Figueiredo Ines , Bogdan Denisa , Cato Laura , Stober Jutta , Jiménez-Vacas Juan M. , Gourain Victor , Lee Irene I. , Seeger Rebecca , Muhle-Goll Claudia , Gurel Bora , Welti Jonathan , Nava Rodrigues Daniel , Rekowski Jan , Qiu Xintao , Jiang Yija , Di Micco Patrizio , Mateos Borja , Bielskutė Stasė , Riisnaes Ruth , Ferreira Ana , Miranda Susana , Crespo Mateus , Buroni Lorenzo , Ning Jian , Carreira Suzanne , Bräse Stefan , Jung Nicole , Gräßle Simone , Swain Amanda , Salvatella Xavier , Plymate Stephen R. , Al-Lazikani Bissan , Long Henry W. , Yuan Wei , Brown Myles , Cato Andrew C.B. , de Bono Johann S. , Sharp Adam
Published: June 2024

Protocols and antibodies for immunohistochemical analyses.