bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplicação do incentivo financeiro do PMAQ, no 3º ciclo, sob a ótica das equipes de saúde e sua influência na qualificação da atenção básica nos municípios da Paraíba
Authors: Lins Adriana da Silva Baltar Maia , Gomes Luciano Bezerra , Leite José Carlos de Lacerda , Sampaio Juliana , Lins Eduardo Antonio Maia
Published: September 2023

Considerando os avanços e desafios acerca do fortalecimento da Atenção Básica, o Programa de Melhoria do Acesso e da Qualidade da Assistência (PMAQ) foi criado, a fim de avaliar a qualidade dos serviços de saúde, a partir do desempenho dos profissionais da Atenção Básica (AB). Este trabalho teve por objetivo analisar o entendimento dos profissionais das equipes de saúde acerca da aplicação do incentivo financeiro do PMAQ e sua influência na qualificação da AB nos municípios da Paraíba. Utilizou-se um banco de dados construído a partir de questionário respondido por trabalhadores das equipes de saúde da AB do estado da Paraíba, no 3º ciclo do PMAQ. A amostra constou de 812 profissionais que foram entrevistados concomitantemente à avaliação externa no ano de 2018. Os resultados dos modelos de regressão logística indicaram que houve um consenso por parte das diferentes categorias profissionais de que a garantia de uma boa remuneração salarial resulta numa melhor prestação de serviços.
NAJCZĘŚCIEJ STOSOWANE TRUCIZNY I SUBSTANCJE TOKSYCZNE. ZNACZENIE TOKSYKOLOGICZNEJ EKSPERTYZY SĄDOWEJ DLA WYMIARU SPRAWIEDLIWOŚCI
Authors: Konieczny Marcin
Published: September 2023

Substancje toksyczne mają wiele zastosowań, jednak żadne z nich nie budzi tak wiele kontrowersji, jak wykorzystywanie ich w celu dokonania morderstwa. Bez wątpienia była to metoda chętnie używana w każdej epoce. Rozwój nauki umożliwił wykrywanie obecności trucizn w organizmie, choć, jak pokazuje praktyka, wyniki badań toksykologicznych nie zawsze są prawdziwe. Artykuł podejmuje problematykę substancji toksycznych stosowanych w celu umyślnego zatrucia i wskazuje na znaczenie ekspertyzy toksykologicznej dla wymiaru sprawiedliwości. Celem opracowania jest omówienie najczęściej stosowanych substancji toksycznych i znaczenia ekspertyz toksykologicznych dla wymiaru sprawiedliwości. W pierwszej części opracowania przybliżono historię substancji toksycznych stosowanych w celach dokonania zabójstwa. Zdefiniowano aparat pojęciowy niezbędny do zrozumienia treści artykułu, z uwzględnieniem takich pojęć, jak substancja toksyczna, trucizna, toksykologia i ekspertyza sądowa. Przedstawiono informacje o najczęściej stosowanych truciznach oraz ich właściwościach w kontekście rozwoju toksykologii. W części drugiej opisano podstawy opiniowania toksykologicznego i zastosowania toksykologicznej ekspertyzy sądowej, która ma na celu identyfikację związków przyczynowych pomiędzy obecnością czynnika toksycznego a reakcją organizmu. W ostatniej części opracowania podjęto zagadnienie znaczenia toksykologicznej ekspertyzy sądowej dla wymiaru sprawiedliwości. Zastosowano metodę analizy piśmiennictwa i danych zastanych.
APARTMENT AND RESIDENCE OF INTER-WAR UNEMPLOYED DIARISTS OF THE SOCIAL ECONOMY INSTITUTE – MEMORIES AND THEIR RECONSTRUCTIONS FROM THE YEARS 1945–1965
Authors: Cesarski Maciej
Published: September 2023

The aim of the article is to read, using a settlement infrastructure concept, the post-war issue of housing and inhabiting in Poland in the period 1945-1965 by t by found authors of unemployed diaries published by the Institute of Social Economy (IGS) in 1933. These issues result from the memoirs of the former unemployed collected by IGS, published in 1967. The article uses a method based on recalling housing and settlement fragments of observations, highlighting the main aspects of housing and inhabiting in each fragment. The method used to capture fates of units of a nature other than unemployment – fates waiting to be included in the structural housing and settlement picture of the first post-war decades in Poland. The final conclusions are an attempt at a synthesis of fates of this units. They also give the opportunity to make only some observations in terms of value and comparison with the results of research on the housing and inhabiting of unemployed IGS diarists in the interwar period and the market transformation in Poland after 1989.
Visibility and invisibility of violence in education
Authors: Rosół Piotr
Published: September 2023

The article describes the connections between theoretical assumptions concerning teaching freedom and the role of authority in education. It also presents Rene Girard’s idea of sacrificial crisis and uses it as an interpretative technique to understand conceptual, bureaucratic, and neoliberal forms of hiding violence. Finally, the author formulates remarks concerning the importance of making violence visible and distinguishing between its manifold forms and cases.
CYBER SECURITY AND OTHER DETERMINANTS OF THE INTERNETIZATION OF LOCAL AND MUNICIPAL MAGAZINES
Authors: Gołębiowska Anna , Prokopowicz Dariusz
Published: September 2023

The main purpose of this article was to point out the growing importance of the issue of cybersecurityin the use of new Internet media in the development of electronic local and local governmentmagazines. This article identifies the importance and impact of the development of new onlinemedia in the process of digitization of documents and the development of electronic, digital versionsof local and self-government magazines. In the context of the conducted research, the followingresearch thesis was formulated: The development of cybercrime related to the theft of sensitivedata on the Internet defines the need for continuous improvement of cybersecurity techniques andinstruments. Improving the cybersecurity in the use of new Internet media is an important factorin the development of electronic and online local and self-government magazines. New onlinemedia, including social media, have become one of the key factors in the current information andsocial globalization. The SARS-CoV-2 coronavirus pandemic significantly accelerated the processesof digitization of the economy and the Internetization of remote communication processes. Theconclusions from the conducted research confirm the main research thesis. The analysis proves thatthere is a fundamental relationship between the improvement of cybersecurity techniques and theprocess of digitization and Internetization of the media, including press media. The article indicatesthe growing importance of cybersecurity in the use of new Internet media in the development ofelectronic local and local government magazines. The considerations and results of the analysescontained in the article confirm the thesis that the development of cybercriminal theft of sensitivedata on the Internet forces the need for continuous improvement of cybersecurity techniques andinstruments. Improvement of the cybersecurity in the use of new Internet media also concerns thedevelopment of electronic and online local and self-government magazines. The text shows theimportance of the role of the Coronavirus pandemic, which occurred in March 2020, in acceleratingthe process of the Internetization of journals.
OPPORTUNITIES OF ADAPTING SPECTRAL IMAGERY IN RESCUE SERVICES OF THE NATIONAL FIRE AND RESCUE SYSTEM
Authors: Olejnik Marcin Kamil
Published: September 2023

The tasks carried out by the National Rescue and Firefighting System (KSRG) require highflexibility of the units of this system. In the event of a crisis over a large area, it may be necessaryto map the crisis area in order to provide assistance effectively, but a simple orthophoto map maynot be sufficient. Bearing in mind the possibility of various threats, the publication analyses thepossibility of using spectral imagery for analyses and mapping of areas affected by a crisis situationto improve the activities provided by the National Rescue and Firefighting System, especially in thecontext of activities provided outside Poland on the basis of international agreements, and so alsoin cases of natural disasters that do not threaten Poland.
Actividades de estimulación temprana para desarrollar la coordinación óculo – manual en niños de Inicial 2.
Authors: Guaranda-Soledispa Rosa Elvira , Guaranda-Soledispa Rosa Elvira , Castro-Bermúdez Idelisa Esther
Published: September 2023

La estimulación temprana de la coordinación óculo manual es un tema de creciente interés dado su impacto en el desarrollo sano y armónico en la infancia, garantía para un proceso de aprendizaje eficaz, que se traduce en mejores condiciones de desarrollo personal y adaptación social. Este estudio se propuso diseñar una propuesta de actividades de estimulación temprana para afianzar el desarrollo de la coordinación óculo manual de los niños de Inicial 2 de la Unidad Educativa Fiscal “Ocho de Enero” de Jipijapa, en Ecuador. Para ello se realizó una investigación mixta con diseño descriptivo, que incluyó 25 niños y dos docentes, se consultaron cinco profesores especializados en el tema. Como resultado, se obtuvo que los docentes, aunque presentaron un adecuado nivel de información sobre el tema, en la práctica se enfocan a la motricidad fina y la percepción visual, las que, aunque son premisas importantes para la coordinación óculo manual, no son las únicas. En estudiantes, se encontró que las destrezas relacionada con la función ejecutiva fueron las de menor desarrollo, mientras que las mejor adquiridas fueron las de motricidad fina. En base a este diagnóstico, se hace una propuesta de actividades, las cuales recibieron opiniones favorables sobre su calidad y pertinencia por parte de los especialistas consultados. Se concluye que la estimulación temprana de la coordinación óculo manual debe ser coherente con los fundamentos teóricos que la explican y que el sistema de actividades propuesto constituye una alternativa pertinente para su incorporación en el entorno escolar y familiar.
Actividades para elevar la motivación del Calentamiento General en la clase de Educación Física.
Authors: González Iturralde Mauricio
Published: September 2023

En la escuela primaria José de la Luz y Caballero del municipio “Jesús Menéndez” de la provincia las Tunas, Cuba, los estudiantes presentaron un bajo nivel de motivación al realizar los ejercicios del Calentamiento General al comienzo de sus clases de Educación Física, fundamentalmente por el poco uso de materiales y actividades motivadoras. El objetivo de este artículo fue diseñar actividades encaminadas a despertar el interés de los estudiantes utilizando variantes de su realización. Las actividades diseñadas se orientan a la inserción de medios en función de contribuir al desarrollo multilateral, la elevación de la motivación, así como, la  preparación integral de los mismos a través de la clase contemporánea. Estas actividades generarán una mejoría significativa de la motivación durante el desarrollo de las actividades, propiciando un desempeño armónico y placentero de los ejercicios.
Class Size and Academic Performance of Senior Secondary School Students in Mensuration in Ogbomoso Education Zone, Nigeria
Authors: ADIGUN Olatunde Thomas
Published: September 2023

This study investigated the influence of class size on the students’ performance in mensuration in Ogbomoso Education Zone, Oyo State, Nigeria. The design of the study was ex-post-facto design. The target population in the geographical scope of this study is thirty- one thousand seven hundred and six (31,706) SS II students out of which a sample of two hundred and seventy four (274) students were selected using purposive sampling technique that form sample size for the study. Two research questions were asked to guide the study while two hypotheses were formulated and tested at 0.05 level of significance. Only one research instrument; Mathematics Performance Test on Mensuration (MPTM) was developed, validated by two experts in Mathematics Education and used to collect data for the study. The instrument yielded reliability coefficient of 0.85 using test retest method to ensure internal consistency of the instrument. Data collected were analysed using mean, standard deviation and t-test. Findings from the study revealed that there was a significant difference in the mean performance scores of students taught in large class size and in small class size. There is no significant difference in the mean performance scores of SS II students taught Mensuration in the rural and urban areas based on class size. Based on the findings, it was recommended, among others, that school principals and other stakeholders who are in charge of admission of students need to take into cognizance the resources available in the schools and the number of students to be given admission
Effect of Motivation on the Performance of Private School Teachers within Jos Metropolis
Authors: Nuhu Gusam Zachariah , Agba Emmanuel Tyohemba , Aliu Omokide Sherifat
Published: September 2023

This paper examines the effect of motivation on the performance of private school teachers. This study was found to be of importance in this era of universal education, especially now that Nigeria needs motivated staff if performance is to be enhanced at this level. The sample of the study was constituted by fifty teachers of diversified societal status, through a 5 point- Likert scale modified survey where each teacher self-rated himself, while their performance was assessed by the school principal on a scale that varied from 0 as a minimum to a 50 as maximum. The researchers have used the frequency, percent, average and the correlation coefficient. Several factors were found to influence the level of teacher motivation. The factors included: level of training, job security, student performance, promotions among others. The researcher also found that in the highly performing schools, all the teachers including those hired by the Board of Management were trained while the schools with low performance had hired some teachers without training. Results have revealed that teachers of the sample lack of motivation and that it is correlated with their performance. The researcher hereby recommends the principals to directing their focus and effort on motivating their teachers to achieve a better performance
Capital Structure and Financial Performance of Listed Oil and Gas Firms in Nigeria
Authors: Olorunlero Solomon Segun
Published: September 2023

Extensive research has been conducted on the relationship between capital structure and financial performance of firms, with the literature documenting the impact of this relationship. In Nigeria, there has been a growing trend of firms consolidating their equity capital as opposed to debt, leading to a need for further investigation into this relationship. This study aims to address this gap by exploring the impact of equity and debt, two capital structure variables, on net profit margin, a measure of financial performance. The study focuses on ten Nigerian listed firms over a decade-long period (2010-2020) and uses published annual reports as the primary data source to ensure the findings are valid and reliable. The selected firms are representative of Nigerian listed firms on the Nigerian Stock Exchange (NSE). Regression analysis using ordinary least square methodology of secondary data indicates that capital structure has a significant positive relationship with the financial performance of Nigeria listed firms, suggesting that these firms have consistently used both debt and equity capital to improve their earnings. The study's results have several implications for managers and investors in Nigeria, including the importance of finding the optimal balance between debt and equity capital to enhance financial performance, the need for proper management of debt levels to avoid excessive leverage and financial distress, and providing insight into the factors that drive the performance of Nigerian listed firms, which can guide investment decisions and strategies. This study adds to the growing body of literature on capital structure and financial performance by analyzing the relationship between capital structure and net profit margin in Nigerian listed firms. The findings suggest that well-managed capital structure positively impacts financial performance and provides valuable insights for managers and investors in Nigeria.
The Feminist Perspective in Agnès Varda’s One Sings, the Other Doesn’t
Authors: Dai Yutong
Published: September 2023

Varda’s most overtly feminist film, One Sings, the Other Doesn’t follows the friendship of two very different women over the course of two decades. This paper is going to analyze the narrative structure of the film from the perspective of feminism, applying Beauvoir’s feminist theory and Shendan’s theory of “implicit process” to the characters of Pauline and Suzanne; Meanwhile, the paper is going to relate the film to the background of Varda’s creation with the analysis of Varda’s creation of women. As a feminist, Varda’s protests are never silent. The “hidden process” that exists underneath the surface, superficial and straightforward narrative content is more worthy of attention and analysis.
Ensayos de alto rendimiento utilizados en farmacognosia: Selección, optimización y validación de métodos de inhibición enzimática por espectrofotometría UV-visible
Authors: Granados-Guzmán Graciela , Waksman de Torres Noemí , Castro-Ríos Rocío , Salazar-Aranda Ricardo
Published: September 2023

In research laboratories of both organic synthesis and extraction of natural products, every day a lot of products that can potentially introduce some biological activity are obtained. Therefore it is necessary to have in vitro assays, which provide reliable information for further evaluation in in vivo systems. From this point of view, in recent years has intensified the use of high-throughput screening assays. Such trials should be optimized and validated for accurate and precise results, i.e. reliable. The present review addresses the steps needed to develop and validate bioanalytical methods, emphasizing UV-Visible spectrophotometry as detection system. Particularly focuses on the selection of the method, the optimization to determine the best experimental conditions, validation, implementation of optimized and validated method to real samples, and finally maintenance and possible transfer it to a new laboratory.
Intervención farmacéutica a pacientes menopáusicas con terapia hormonal de reemplazo en una farmacia comunitaria de Antofagasta
Authors: Alucema Alejandrina , González Silvia C. , Valenzuela Ingrid , Valdés Marisela
Published: September 2023

Context: Hormone replacement therapy (HRT) is the most widely used treatment for controlling the effects of menopause. This type of therapy causes some drug-related problems (DRP), which requires monitoring to control the negative effects and ensure patient adherence to therapy. Aims: Perform a pharmacotherapeutic monitoring and educate to menopausal patients in HRT of a community pharmacy from the city of Antofagasta. Methods: A 98-menopausal patients underwent a pharmaceutical intervention to identify the PRM and its resolution. It was applied to them a survey before and after educational activities about this disease and HRT to determine the knowledge on the subject. Results: During the pharmacotherapeutic monitoring was determined that 55% of patients using combined HRT. 62 DRPs were detected, of which 43 were resolved (69%); the most were Patient-Pharmacist (73%). The better resolution DRP were DRP 4(b) “frequency of inadequate administration” and DRP 2(a) “no medical indication”. At baseline, 90% had an inadequate level of knowledge about the disease and THR, 8% intermediate, and only 2% adequate. After the implementation of the education strategy, the level of knowledge increased, achieving at the end of the study only intermediate (10%) and adequate (90%) levels. Conclusions: The results confirm the importance of pharmaceutical intervention for the identification and resolution of DRP and the requirement to establish educational strategies to increase the knowledge about menopause and HRT in menopausal patients.
Antioxidant activity, total phenols and flavonoids of lichens from Venezuelan Andes
Authors: Plaza Claudia M. , Díaz de Torres Lorena E. , Lücking Robert K. , Vizcaya Marietta , Medina Gerardo E.
Published: September 2023

Context:The biological potential of lichens has been documented through their use in traditional medicine. Secondary lichen metabolites exert a wide variety of biological actions, including their use as antioxidants. Aims:To evaluate the antioxidant activity, total phenol content, and flavonoids of four lichen fungal taxa collected in Mérida (Venezuela), and statistically evaluate the correlation between the antioxidant activity and the amount of phenols and flavonoids in the samples. Methods: Extracts were prepared with water, ethanol and dichloromethane from Cladonia aff. rappii, Cora aff. glabrata, Peltigera laciniata and Thamnolia vermicularis. The antioxidant capacity assessment was determined using DPPH• radical method and reducing power, with ascorbic acid as control. Total phenols were determined by means of the Folin-Ciocalteu method with gallic acid. Total flavonoids were estimated according to the modified Dowd method, using quercetin as standard. Results:The ethanolic extracts of the tested lichens showed the highest scavenging activity and reducing power compared to water and dichloromethane extracts at 4 mg/mL. The highest antiradical power value was found in ethanolic extract of Peltigera laciniata (2.28 mL/mg)and the lowest in dichloromethane extract of Cora aff. glabrata (0.30 mL/mg). The correlation between antioxidant activity and total phenolic content was moderate. The flavonoids content of ethanolic extracts was highly significant but negative (p < 0.05). There was good correlation in dichloromethane extracts. The ethanolic extract of P. laciniata exhibited the highest antiradical activity despite showing the lowest flavonoid content. Conclusions: The ethanolic extracts of lichens tested showed to have the higher antioxidant activity and may be used as natural sources of new antioxidants.
Uso de protectores gástricos en la profilaxis de úlcera por estrés en el Servicio de Medicina del Hospital Regional de Antofagasta: Julio a diciembre de 2014
Authors: Tapia Aguirre Silvana
Published: September 2023

La tesis está vinculada con el área clínica del sistema gastrointestinal. La prescripción de protectores gástricos para las úlceras por estrés ha ido aumentando durante el tiempo siendo inapropiado en ocasiones su uso, por lo que se evaluó la utilización de protectores gástricos en la profilaxis de úlcera por estrés en pacientes internados en el servicio de medicina del Hospital Regional de Antofagasta, durante 6 meses, con el fin de analizar el uso de estos medicamentos en el centro asistencial. Este estudio fue prospectivo de tipo descriptivo-experimental, que consistió en hacer seguimiento en dos grupos de estudio, denominados control y caso, en el que se realizaron intervenciones en el segundo grupo. Como resultado se obtuvo que en el grupo control el uso correcto de protectores gástricos fue menor en comparación al grupo caso. El omeprazol fue el medicamento más utilizado. La tesis está constituida por 78 páginas y su estructura comprende una introducción, cuatro capítulos, referencias bibliográficas y otras informaciones (anexos).
Phytochemical analysis and antibacterial activity on seed and pod extracts of Crotalaria incana
Authors: Alemu Mathewos Anza , Mekonnen Habtamu Gelaw , Annisa Milkyas Endale
Published: September 2023

Context: Crotalaria incana L. (Fabaceae) is used for various traditional medicinal treatments such as astringent, jaundice and palpitation, inflammation, skin disease and purgative. Aims: To investigate the phytochemical constituents and evaluate the antibacterial activity of seed and pod extracts of C. incana. Methods: Phytochemical screening tests were conducted to identify the class of compounds present in the dichloromethane/methanol (1:1) extracts of seed and pod. Silica gel column chromatographic technique was applied to separate the constituents of the extracts. Various spectroscopic techniques (IR, NMR (1H, 13C and DEPT-135) were applied to determine the structures of isolated compounds. Antibacterial activities were evaluated via disc diffusion method. Results: Preliminary phytochemical screening of seed and pod extracts of C. incana L. revealed the presence alkaloids, flavonoids, triterpenes, tannins and steroids and absence of anthraquinones. Silica gel column chromatography separation of the extract yielded a known steroid β-sitosterol (1) and 1-nonadecanol (2). Evaluation of antibacterial activity of crude extract via disc diffusion method against Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia and Salmonella typhi showed moderate susceptibility of this selected Gram-positive and Gram-negative bacteria strains, comparable to the activity of the antibiotic (gentamicin). Conclusions: The compound (2) (1-nonadecanol) was isolated for the first time from the C. incana. These results proved that polar extracts of the seeds and pods of C. incana possess antibacterial activity.
PROJETO PREVENIR E A REALIZAÇÃO DE AÇÕES DE EDUCAÇÃO E PROMOÇÃO DE SAÚDE
Authors: Marine Wiggers Eliz , Roslindo Paranhos William
Published: September 2023

O Projeto Prevenir nasce vinculado ao Curso de Psicologia do Centro Universitário Avantis (Uniavan) com o intuito de atuar, dentre outros campos, como um interlocutor e parceiro do Centro de Testagem e Aconselhamento (CTA) de Balneário Camboriú/SC, no intuito de promover a qualificação e profissionalização de futuros profissionais da área. O objetivo principal deste artigo é relatar a trajetória do Projeto Prevenir. Das estratégias efetivadas pelo projeto, fundamentadas na educação sexual entre pares, merecem destaque o desenvolvimento de facilitadores entre acadêmicos objetivando desmistificar informações equivocadas e disseminadas socialmente sobre infecções sexualmente transmissíveis (IST) e o vírus da imunodeficiência humana (HIV), bem como a ampliação das ações de promoção de saúde além do contexto universitário e da lógica biologicista, considerando o viver e a integralidade humana em suas intersecções.
US WITHDRAWAL PROCESS FROM AFGHANISTAN AND ITS EFFECTS ON INTERNATIONAL RELATIONS
Authors: TAŞLICALI KOÇ Tuba , ŞEKER Burak Şakir
Published: September 2023

This article’s main concern is to come to an understanding of the reasons why the Afghan army could not be successful

against the Taliban during the withdrawal process and what the effects were of this failure on international relations.

The main argument in the study about the failure of the Afghan Army is that because the transition stages from

the lower identity to the upper have not been completed, and the identity structure was left as a tribal-based one

rather than integrated Afghan identity, the loyalty to the state could not be fulfilled and therefore the practices like

bribery or favouritism in assignments led to corruption in the system causing an imperfect structure with a failure

against the Taliban. As to the effects on international relations, the withdrawal of the USA from the region caused

the power vacuum in Afghanistan to deepen even more. Whilst analyzing the aspects of the reasons why the Afghan

army had failed against the Taliban, the on-site observation method is used lasting 6 months between June 2017 and

January 2018 and the on-site interviews were personally carried out during this aforementioned time period.
GELENEKSEL KAHRAMAN KALIBI BAĞLAMINDA İKİ KARDEŞ KAHRAMANLI TÜRK DESTANLARI ÜZERİNE DEĞERLENDİRME
Authors: AKSOY Hüseyin
Published: September 2023

Destan metinlerini çeşitli yönleriyle tahlil ederek onların yaratıldığı toplumun yaşam tarzları ve dünya görüşlerine

dair tespitlerde bulunulmak mümkündür. Nitekim buna bağlı olarak gerek Batı gerekse Türk destanlarını tahlil etmek

için geçmişten günümüze pek çok yöntem denenmiş ve ulaşılan sonuçlar üzerinden destanın ait olduğu halka

dair çıkarımlarda bulunulmuştur. Destan araştırmalarında dikkati kahramana vermek ve onun biyografisi üzerinden

çıkarımlarda bulunmak araştırmalarda en çok izlenen yol olagelmiştir. Bu sayede özellikle destan metinlerine odaklanan

ilk çalışmalarda çeşitli benzerliklerin varlığı tespit edilmiş ve böylece farklı araştırmacıların kahraman kalıpları

ortaya konmuştur. Bu kalıplardan faydalanarak Türk dünyası destanları da pek çok çalışmada incelenmiştir. Bu

çalışmalarda varılan ortak sonuç bazı kültürel farklılıkları olmakla birlikte dünya destanlarında ortak bir kahraman

kalıbının mevcudiyeti olmuştur. Bu kültürel farklılıkları belirlemek için Türk dünyası destanları özelinde çalışmalar

gerçekleştirilmiş ve Türk destanlarındaki kahramanlık kalıbı ortaya konulmuştur. Destan kahramanı hakkında yapılan

bu çalışmalarda genellikle tek başkahramanı olan destanlara odaklanılmış, birden fazla başkahramanı olan

destanlar (kardeş kahramanlı destanlar) hakkında çok fazla çalışma ortaya konmamıştır. Bu çalışmada birden fazla

kahramana sahip Türk dünyası destanlarından “Er Soltonoy, Erali Şirali ve Er Samır” destanları örneklem olarak

seçilmiş ve bu destanlar merkezî kahraman kalıbı bağlamında karşılaştırmalı olarak incelenmiştir.
ICH M10 guideline - a harmonized global approach to bioanalysis
Authors: Gniazdowska Elżbieta , Gilant Edyta , Buś-Kwaśnik Katarzyna
Published: September 2023

Bioanalytical methods are used in research on small-molecule and large-molecule drug products to determine analytes and their metabolites in biological matrices such as blood, plasma, serum, urine, feces, saliva, other biological fluids, or tissues. Validation of a bioanalytical method is the essential step before the implementation of the method into routine use in toxicokinetic or pharmacokinetic studies. Harmonization of recommendations for the validation of bioanalytical methods has been advocated for many years. In 2022, The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) finished the work on final version of the ICH M10 guideline, as a combination of four regional guidelines (American, European, Brazilian and Japanise). The document uniforms rules for the performance of the bioanalytical method validation and documentation of sample analysis from clinical and non-clinical studies in most countries around the world, which are submitted to registration authorities.
The Impact of Age Management on Human Resources Management in Czech Public Companies
Authors: Krestova Terezie , Demlova Tereza
Published: September 2023

Environmental changes can have significant effects on organizations, particularly demographic changes such as the ageing of the population, changes in age structure, and changes in employee behaviour. All of these factors must be taken into account in human resources management. This paper presents the results of a survey conducted in Czech companies, which aimed to identify whether organizations consider the diverse needs of different age groups, apply age management measures, and observe benefits. The study is based on quantitative data collected through the survey. Moreover, a convenient sampling technique was adopted to approach the respondent. A total of 622 respondents participated in the survey. The study found that the most significant benefits were the retention of key employees, reduced employee turnover, and increased employee motivation. The most commonly used measures include adapting work programs to suit different age groups, reassigning staff to more suitable positions, providing employee healthcare, promoting physical fitness and healthy eating, and supporting personal and career development through skills training at all stages of an employee's career. The results recommend that age factors differ in different sectors and organizations. Therefore, this study can be replicated in other contexts.
Comunicación corporativa digital para el fortalecimiento de la identidad organizacional en el ciberespacio
Authors: Parra Morales Aura Elisa
Published: September 2023

En una realidad laboral en la cual las relaciones se desarrollan en dos ámbitos paralelos, pero también complementarios: la realidad física y el ciberespacio, la comunicación corporativa precisa crear propuestas que fortalezcan la identidad de los públicos, a fin de profundizar su implicación en el desarrollo de la organización. Por tal motivo, el presente estudio tuvo como propósito interpretar, en las interacciones de los públicos, el tipo de mensaje organizacional que fortalece la identidad corporativa, propuesta que se sustentó en los postulados teóricos de Del Fresno (2011) en cuanto a la incidencia de la etnografía digital en el estudio de la identidad desde la comprensión de significados simbólicos. Se partió de la concepción de la cultura de Geertz (1973) como construcción simbólica y de la definición de comunicación corporativa de Costa (2006) quien la cataloga como un sistema integrado de intercambio de mensajes. En términos metodológicos se recurrió a la etnografía digital, a través un chat de WhatsApp, aplicado a una muestra de 13 trabajadores administrativos de la Universidad Centroccidental Lisandro Alvarado, complementado con una entrevista abierta a la alta gerencia, de cuyas propuestas se extrajeron categorías que permitieron dar respuesta a los objetivos de la investigación. En los resultados obtenidos se detectó la necesidad de una comunicación que reconozca el sentido de pertenencia, el compromiso y el cariño filial afianzado en los empleados; así mismo, se calificó a la comunicación digital como una herramienta para profundizar la visualización y percepción en los públicos internos y externos.
Voicing The Woes of The Tribals in The Works of Mahasweta Devi
Authors: Rashmi Singh and Dr.Nisha Gupta
Published: September 2023

- Mahasweta Devi is a great name in the field of Tribals literature. She is the only writer among Indian writers in English who could prove her sympathy and kindness towards the tribals. Through, Devi was born and brought up in a family that produced scholars and sympathetic people. During her childhood and schooling days, she made wonders by proving herself a great scholar. After her marriage, she blossomed into a professional writer by writing on the topic of sorrows and sufferings by traveling to the areas of tribals and living with them to wipe their tears who were downtrodden and marginalized. These tribals whose stories Devi has taken into living record made Devi a famous and reputed writer of her time and among her contemporaries. She has been fully dedicated to the tribals who were voiceless or could not speak in their favor of them before the rich and zamindars. These people were so poor, if they took money on loan, could never recover, as the interest rate was so high and under such conditions, they were to work at the big forms of the money lenders and their wives were to work at the homes of the rich and landlords.
The Influence of Leading Sector Grdp And Special Autonomy Funds on Poverty In Aceh Province
Authors: Aulianur Ahlul , Effendi Rustam , Abrar Muhammad
Published: September 2023

The purpose of this study is to analyze the effect of leading sector GRDP and special autonomy funds on poverty in Aceh Province. This study employs quantitative techniques by regressing quarterly time series data for the years 2010 to 2022. The agriculture, mining, trade, transportation, real estate, administration, health services sectors are the leading sectors obtained from the Location Quotient (LQ) calculation. The results showed that the agriculture, trade and transportation sectors have a negative effect on poverty. the real estate and administration sector has a positive effect on poverty. Meanwhile, the mining and health services sectors have no effect on poverty. Special autonomy funds have a negative effect on poverty in Aceh Province. The agriculture, trade, transportation sectors are considered as sectors that should be the focus of development and funding from the allocation of special autonomy funds by the Government of Aceh.
In-silico and structure-based assessment to evaluate pathogenicity of missense mutations associated with non-small cell lung cancer identified in the Eph-ephrin class of proteins
Authors: Chakraborty Shubhashish , Baruah Reshita , Mishra Neha , Varma Ashok K
Published: September 2023

Ephs belong to the largest family of receptor tyrosine kinase and are highly conserved both sequentially and structurally. The structural organization of Eph is similar to other receptor tyrosine kinases; constituting the extracellular ligand binding domain, a fibronectin domain followed by intracellular juxtamembrane kinase, and SAM domain. Eph binds to respective ephrin ligand, through the ligand binding domain and forms a tetrameric complex to activate the kinase domain. Eph-ephrin regulates many downstream pathways that lead to physiological events such as cell migration, proliferation, and growth. Therefore, considering the importance of Eph-ephrin class of protein in tumorigenesis, 7,620 clinically reported missense mutations belonging to the class of variables of unknown significance were retrieved from cBioPortal and evaluated for pathogenicity. Thirty-two mutations predicted to be pathogenic using SIFT, Polyphen-2, PROVEAN, SNPs&GO, PMut, iSTABLE, and PremPS in-silico tools were found located either in critical functional regions or encompassing interactions at the binding interface of Eph-ephrin. However, seven were reported in nonsmall cell lung cancer (NSCLC). Considering the relevance of receptor tyrosine kinases and Eph in NSCLC, these seven mutations were assessed for change in the folding pattern using molecular dynamic simulation. Structural alterations, stability, flexibility, compactness, and solvent-exposed area was observed in EphA3 Trp790Cys, EphA7 Leu749Phe, EphB1 Gly685Cys, EphB4 Val748Ala, and Ephrin A2 Trp112Cys. Hence, it can be concluded that the evaluated mutations have potential to alter the folding pattern and thus can be further validated by in-vitro, structural and in-vivo studies for clinical management.
Identifying pathogenic variants related to systemic lupus erythematosus by integrating genomic databases and a bioinformatic approach
Authors: Yudhani Ratih Dewi , Pakha Dyonisa Nasirochmi , Suyatmi Suyatmi , Irham Lalu Muhammad
Published: September 2023

Systemic lupus erythematosus (SLE) is an inflammatory-autoimmune disease with a complex multi-organ pathogenesis, and it is known to be associated with significant morbidity and mortality. Various genetic, immunological, endocrine, and environmental factors contribute to SLE. Genomic variants have been identified as potential contributors to SLE susceptibility across multiple continents. However, the specific pathogenic variants that drive SLE remain largely undefined. In this study, we sought to identify these pathogenic variants across various continents using genomic and bioinformatic-based methodologies. We found that the variants rs35677470, rs34536443, rs17849502, and rs13306575 are likely damaging in SLE. Furthermore, these four variants appear to affect the gene expression of NCF2, TYK2, and DNASE1L3 in whole blood tissue. Our findings suggest that these genomic variants warrant further research for validation in functional studies and clinical trials involving SLE patients. We conclude that the integration of genomic and bioinformatic-based databases could enhance our understanding of disease susceptibility, including that of SLE.
M Protein from Dengue virus oligomerizes to pentameric channel protein: in silico analysis study
Authors: Zeba Ayesha , Sekar Kanagaraj , Ganjiwale Anjali
Published: September 2023

The Dengue virus M protein is a 75 amino acid polypeptide with two helical transmembranes (TM). The TM domain oligomerizes to form an ion channel, facilitating viral release from the host cells. The M protein has a critical role in the virus entry and life cycle, making it a potent drug target. The oligomerization of the monomeric protein was studied using ab initio modeling and molecular dynamics (MD) simulation in an implicit membrane environment. The representative structures obtained showed pentamer as the most stable oligomeric state, resembling an ion channel. Glutamic acid, threonine, serine, tryptophan, alanine, isoleucine form the pore-lining residues of the pentameric channel, conferring an overall negative charge to the channel with approximate length of 51.9 Å. Residue interaction analysis (RIN) for M protein shows that Ala94, Leu95, Ser112, Glu124, and Phe155 are the central hub residues representing the physicochemical interactions between domains. The virtual screening with 165 different ion channel inhibitors from the ion channel library shows monovalent ion channel blockers, namely lumacaftor, glipizide, gliquidone, glisoxepide, and azelnidipine to be the inhibitors with high docking scores. Understanding the three-dimensional structure of M protein will help design therapeutics and vaccines for Dengue infection.
A System Architecture Based on The RNN Classifier for Heart Disease Detection
Authors: Göreke Volkan
Published: September 2023

Diagnosing heart disease is a challenging process for physicians. Insufficient number of experts, late diagnosis and misdiagnosis are the difficulties in this process. To overcome these difficulties, systems based on artificial intelligence are used today. Appropriate system selection and obtaining sufficient data sets are a challenge for researchers. In this study, a high-performance CAD architecture was proposed for the detection of heart disease. The proposed architecture has shown a higher performance than the studies carried out using the UCI dataset in the literature.
Impact of rail infrastructure charging systems implemented in europe on the competitiveness of high speed services
Authors:   , Sánchez Borràs Marta
Published: September 2023

European railways have been immersed since the nineties in a restructuring process aimed at improving the effectiveness, quality and economic efficiency of the provision of railway services, as well as stimulating the growth of railway markets. This reform has involved a separation between infrastructure management and operation and the introduction of rail infrastructure charges to regulate the use, by railway undertakings, of the infrastructure managed by infrastructure managers.
Rail infrastructure charges aim, in essence, at recovering costs. Nevertheless, they can have an influence on the usage of the infrastructure, especially in corridors where competition between modes exists. Therefore, special attention should be paid to their definition and amount to ensure that they do not counteract the important effort that the European Union is making to help finance and build a European high speed network aimed at strengthening railways and redressing modal share imbalances.
In Europe, legislation requires transparent and non discriminatory rail access charges, based on the principles of short run marginal social cost although mark ups are permitted where necessary to meet financial requirements. However, it does not specify how these principles should be implemented.
This dissertation has three main tasks. Firstly, it calculates the amount of rail infrastructure charge for European high speed lines/services based on the marginal cost. Secondly, it characterises the rail infrastructure charging systems applied to European high speed lines/services, in order to detect if mark ups above the marginal cost of wear and tear are being applied to those services and if so, how they are applied. Finally, it quantifies the impacts on traffic volumes and mode split resulting from bringing the current levels of rail infrastructure charges (applied in the European high speed network) to the level of marginal cost of maintenance and renewals and to the optimal Ramsey mark up.
According to the results obtained, current levels of rail infrastructure charges implemented in Europe have a negative impact on the competitiveness of the high speed passenger services that run on the European railway network, particularly in the cases where the rail market share is currently low (below 80-85%). Thus, mark ups would not have been imposed after careful consideration of their consequences on the market position of railway undertakings in the market segment in question.
Active traffic management in metropolitan freeways : modeling and assessing dynamic speed limit strategies
Authors:   , Torné Santos Josep María
Published: September 2023

Traffic congestion is a major source of inefficiencies in metropolitan freeways (e.g. productivity loss, energy waste, pollutant emissions, among other externalities). Active traffic management (ATM) strategies are used in order to face the problem and alleviate its effects by managing recurrent and non-recurrent congestion with a combination of real-time and predictive operational strategies.
Dynamic speed limit management (DSL) is an ATM tool believed to bring some benefits to freeway traffic, like the increase in capacity and/or the vehicle' speed homogenization. Currently it is being implemented in many metropolitan freeways worldwide. This thesis is devoted to assess such conceptual benefits with empirical data and robust traffic flow models.
Empirical data are obtained from the C-32 freeway in Barcelona, the first DSL implementation in Spain. The detailed analysis of these data allows characterizing the effects of DSL management on traffic behavior. It is found that, under the right conditions, DSL can increase capacity due to a reduction in the speed dispersion across lanes. This finding allows defining new ATM policies.
A coordinated strategy for traffic management considering both ramp metering and DSL is proposed in order to reduce the capacity drop phenomenon in the vicinity of a freeway on-ramp. The effectiveness of this control method is tested using simulation with an extension of the traditional cell transmission model, which incorporates the ability to reproduce DSL, together with the capacity drop. Results show amelioration in the performance indicators of the system, highlighting the equity-friendly component of this coordinated strategy.
Finally, results from a cost-benefit assessment of DSL considering the main externalities suggest that the social profitability of DSL management in metropolitan freeways is limited when applied alone. The potential synergies of applying a ¿pack¿ of different ATM strategies in a coordinated way, define challenging issues for further research.
Arquitectura i aprenentatge
Authors: Muntañola Thornberg José
Published: September 2023

Aquest llibre té com a tema les relacions entre aprenentatge i el mateix projecte d'arquitectura. Els arquitectes nordamericans d'origen europeu Lars Lerup i Marc Mack ens comuniquen amb gran precisió les seves actituds amb relació al valor cultural de l'arquitectura; i fa el mateix l'excel·lent arquitecte nordamericà Joseph Esherick, malauradament poc conegut en les nostres latituds.