bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards a smart glasses society? Ethical perspectives on extended realities and augmenting technologies
Authors: Tretter Max , Hahn Michael , Dabrock Peter
Published: May 2024

The release of Apple Vision Pro in early February and the subsequent media coverage have pushed Mixed Reality (MR) and augmenting technologies into public consciousness, raising the question of whether we are moving towards a “smart glasses society” where wearing MR-devices in public becomes commonplace, and regularly engaging with extended realities will be part of our everyday experience. This paper delves into the ethical implications of this potential development, scrutinizing the effects smart glasses may have on our humanity, our relation to the world, and our shared-life world. It calls for a nuanced approach that earnestly engages with these concerns while maintaining a composed outlook, recognizing that many of these issues discussed in the context of immersive technologies, although they seem new, have been with us for quite some time.
Exploring unmet needs and preferences of young adult stroke patients for post-stroke care through PROMs and gender differences
Authors: Ibrahim Sarah , Francis Troy , Sheehan Kathleen A. , Kokorelias Kristina , Stanimirovic Aleksandra , Hashmi Syeda , Kalocsai Csilla , Ng Sharon , Berkhout Suze G. , Cameron Jill I. , Rac Valeria , Pikula Aleksandra
Published: May 2024

Background

Stroke incidence among young adults of working age (under 65 years of age) has significantly increased in the past decade, with major individual, social, and economic implications. There is a paucity of research exploring the needs of this patient population. This study assessed: (1) young adult stroke patients' physical, psychological, and occupational functioning and health-related quality of life (HRQoL); and (2) post-stroke care preferences using patient-reported outcome measures (PROMs), with attention to gender differences.

Methods

A cross-sectional pilot study was conducted. Sociodemographic and clinical characteristics were collected through chart review and data on occupational function, physical, psychological, and social wellbeing >90 days post-stroke through a self-reported survey. Descriptive statistics, gender-based, and regression analyses were conducted.

Results

The sample included 85 participants. Participants reported impairments in both, occupational functioning, with 58.7% not returned to work (RTW), and HRQoL, specifically with social activities (37%), anxiety (34%), and cognitive function (34%). Women had significantly (p < 0.05) worse physical symptoms (sleep disturbance and fatigue), emotional health (depression, stigma, emotional dyscontrol) scores, and sense of self-identify post-stroke. Over 70% of participants preferred in-person post-stroke care led by health care providers and felt they would have benefited from receiving information on physical health (71.4%), emotional and psychological health (56.0%), RTW (38.1%), and self-identity (26.2%) post-stroke. Women preferred cognitive behavioral therapy (p = 0.018) and mindfulness-based stress reduction therapy (p = 0.016), while men preferred pharmacotherapy (p = 0.02) for psychological symptoms.

Conclusion

This is the first study to report impaired HRQoL, psychological and occupational functioning using PROMs, with significant gender differences and preferences for post-stroke care delivery among young adult stroke patients at >90 days after stroke. The findings highlight the importance of needs, gender, and age-specific post-stroke education and interventions.
Ultrasound biomicroscopy analysis of ciliary muscle dynamics and its relation to intra-ocular pressure after phacoemulsification in dogs
Authors: Kim Donghee , Park Sang-Eun , Hwang Jiyi , Kang Nanyoung , Jung Ji Seung , Park Kyung-Mee
Published: May 2024

Introduction

This study investigates the relationship between ciliary muscle dynamics, thickness, and the regulation of intraocular pressure (IOP), focusing on the progression of cataracts and changes post-phacoemulsification. It explores how these factors impact canine ocular health, particularly in the context of cataract development and subsequent surgical intervention.

Materials and methods

Data was collected using Ultrasound Biomicroscopy (UBM) from dogs at the Veterinary Medical Teaching Hospital of Chungbuk National University, Korea. The study involved 57 eyes from 35 dogs, categorized into five groups: 13 normal eyes, 14 with incipient cataracts, 12 with immature cataracts, 6 with mature cataracts, and 12 post-phacoemulsification. UBM measurements assessed various ciliary muscle parameters including ciliary body axial length (CBAXL), ciliary process-sclera angle (CPSA), longitudinal fibers of ciliary muscle thickness (Lf-CMT), and longitudinal and radial fibers of ciliary muscle thickness (LRf-CMT).

Results

Findings indicated a decrease in CBAXL and an increase in Lf-CMT as cataracts progressed in severity. Post-phacoemulsification, there was a notable increase in CBAXL and a decrease in CPSA, Lf-CMT, and LRf-CMT, compared to both cataractous and normal eyes. Regression analysis revealed a significant positive association between CBAXL and IOP, alongside a negative association between Lf-CMT and IOP. These findings suggest that variations in ciliary muscle dynamics and thickness, as influenced by cataract progression and phacoemulsification, have distinct impacts on intraocular pressure.

Discussion

The study proposes that phacoemulsification leads to ciliary muscle contraction, causing an inward and anterior movement of the ciliary muscle. This movement results in the narrowing of the ciliary cleft and constriction of the unconventional outflow pathway, potentially causing an increased risk of glaucoma post-surgery. Our research contributes to understanding the anatomical and physiological changes in the canine eye following cataract surgery and underscores the importance of monitoring IOP and ciliary muscle dynamics in these patients.
Outcome in paraplegic dogs with or without pain perception due to thoracolumbar fibrocartilaginous embolic myelopathy or acute non-compressive nucleus pulposus extrusion
Authors: Togawa Go , Lewis Melissa J. , Devathasan Dillon
Published: May 2024

Background

Fibrocartilaginous embolic myelopathy (FCEM) and acute non-compressive nucleus pulposus extrusion (ANNPE) are common causes of acute spinal cord injury in dogs. Outcome among paraplegic deep pain positive (DPP) and deep pain negative (DPN) dogs with either condition and factors influencing recovery have not been clearly established.

Methods

Dogs with thoracolumbar FCEM or ANNPE resulting in paraplegia presenting to university hospitals between 2012 and 2022 were retrospectively included. Diagnosis of FCEM or ANNPE was based on clinical and magnetic resonance imaging findings. Outcome was defined as successful (recovery of independent ambulation) or unsuccessful (non-ambulatory ≥3 months following diagnosis or at the time of death/euthanasia). Logistic regression analysis was performed to investigate associations between clinical or imaging variables and outcome.

Results

Thirty-one dogs were included. In total, 14 dogs were initially paraplegic DPP (8 FCEM, 6 ANNPE) and 17 dogs were paraplegic DPN (11 FCEM, 6 ANNPE). Outcome was available for 26 dogs (14 DPP, 12 DPN) with a median follow-up time of 182 days (range 0–2,311) including 2 dogs euthanized at the time of diagnosis; 1 of 12 DPN dogs (8.3%) regained independent ambulation, whereas 9 of 14 DPP dogs (64.3%) regained independent ambulation. DPN dogs had a significantly higher risk of not regaining independent ambulation compared with DPP dogs (OR: 47.40, 95% CI: 2.09–1073.99). No other variables were associated with outcome.

Conclusion

While recovery of ambulation was possible, these results confirm that the absence of pain perception is a useful negative prognostic indicator in dogs with severe thoracolumbar FCEM or ANNPE.
Morphological and morphometric measurement of the temporomandibular joint of small and medium-weight dogs with different skull shapes
Authors: Quadflieg Ina , Volk Holger A. , Sake Björn , Metje Benjamin
Published: May 2024

Background

The recognition and diagnosis of canine temporomandibular joint (TMJ) disease can be a challenge, often leaving them undiagnosed. Although computed tomography (CT) has proved to be highly efficacious in detecting joint disease in the TMJ, morphometric and morphological studies of the normal TMJ have been scarce. Especially, skull type specific anatomical differences of the TMJ in dogs of different weights and skull morphologies have received limited attention.

Objective

This study aimed to compare the TMJ morphologies of dogs across different weight classes and skull types.

Study design

Retrospective study.

Methods

CT scans were used to measure the depth and width of the Fossa mandibularis and two angles between the Fossa mandibularis and the Caput mandibulae in a total of 92 dogs and 182 mandibular joints, respectively.

Results

The TMJ varied in terms of weight groups and skull indices. Shallow mandibular pits, underdeveloped retroarticular processes, and reduced joint congruency were observed particularly in light-weight and brachycephalic dogs. Conversely, dolichocephalic animals displayed deep joint pits, pronounced joint congruency, and a well-developed Processus retroarticularis.

Main limitations

Observer learning curve; not every skull shape was represented in each weight group.
Molecular Composition of Humic Acids of Different Aged Fallow Lands and Soils of Different Types of Use in Northwest of Russia
Authors: Polyakov Vyacheslav , Nizamutdinov Timur , Abakumov Evgeny
Published: May 2024

Post-agrogenic transformation of fallow soils leads to changes in soil carbon content, the molecular composition of humic substances, and rates of organic matter stabilization, which can affect climate change on the planet. In this regard, we analyzed the molecular composition of humic acids isolated from natural and fallow soils in the southern Taiga zone of northwest Russia. Different-aged soils on fallow lands represent a model of soil transformation in time, and data on the transformation of soil humic acid molecular composition make a significant contribution to the understanding of soil organic matter stabilization aspect issues. In this case, the molecular structure of humic acids isolated from natural and fallow soils in northwest Russia was analyzed. To study the molecular composition of HAs, the elemental composition was analyzed, and 13C (CP/MAS) NMR spectroscopy of HAs isolated from different aged abandoned soils and soils of different types of use was carried out. The obtained data showed that with the increasing age of soils in the fallow state, there is an increase in the carbon content of humic acids as well as a decrease in nitrogen content. As a result of the increasing age of soils in the fallow state, there are dynamics in the content of aromatic structural fragments in humic acids: 34% for 40 years old, 28% for 80 years old, and 31% for 120 years old. This is due to changes in the precursors of humification and the further transformation of plant residues in the soil. Re-involved fallow land soils lead to an increase in the content of aromatic structural fragments in the composition of HA in relation to HA extracted from mature soils. The lowest content of aromatic structural fragments was observed in the humic acids of 130-year-old agricultural soil, which is associated with the long-term application of organic fertilizers.
Large-Scale Fire Tests of Battery Electric Vehicle (BEV): Slovak Case Study
Authors: Svetlík Jozef , Tancos Zoltan , Tancos Petr , Markova Iveta , Slastan Kristian
Published: May 2024

Due to the increasing number of battery electric vehicles (BEV) on the roads and the number of BEV accidents with the occurrence of a fire, full-scale fire tests of BEVs were carried out. For initiation, the BEVs were mechanically damaged, forming a gap with a size of 15 cm × 15 cm. The external heat source was a 300 kW propane burner with a maximum power of 54.0 kW and a length of 54 cm. The flame of the propane–butane fuel mixed in air at a temperature of 1970 °C was inserted directly into the battery pack. The increase in the temperature was monitored as a function of time through thermocouples at selected locations of the BEV until the point of initiation. Thermocouples were placed 10, 30, and 50 cm from the place of BEV surface. Accordingly, to obtain the temperature–time curves from the experiment measurement, critical temperatures were subsequently evaluated. The fire tests on BEVs can be described according to the individual phases of the fire. The external heat source started the initiation process at the 25 min time mark. Consequently, the phase of a developed fire with a dynamic course started. A sharp rise in temperature occurred. Within two minutes, the temperature rose to 1056.9 °C. After the initiation source was removed, there was decline in temperature and re-ignition to the stage of a fully developed fire. Thermocouples recorded temperatures in the range of 900 °C. The resulting dynamic process of a BEV fire with a sharp increase in temperature is a problem for the implementation of firefighting works and the liquidation of traffic accidents. Furthermore, foam extinguishing was part of the experiments. In both cases after the foam application, the temperature on the thermocouple T1 (distance was 10 cm from the surface of the BEV) dropped from 486.1 °C to 76 °C after 10 s of application.
Data Acquisition, Processing, and Aggregation in a Low-Cost IoT System for Indoor Environmental Quality Monitoring
Authors: Barbaro Alberto , Chiavassa Pietro , Fissore Virginia Isabella , Servetti Antonio , Raviola Erica , Ramírez-Espinosa Gustavo , Giusto Edoardo , Montrucchio Bartolomeo , Astolfi Arianna , Fiori Franco
Published: May 2024

The rapid spread of Internet of Things technologies has enabled a continuous monitoring of indoor environmental quality in office environments by integrating monitoring devices equipped with low-cost sensors and cloud platforms for data storage and visualization. Critical aspects in the development of such monitoring systems are effective data acquisition, processing, and visualization strategies, which significantly influence the performance of the system both at monitoring device and at cloud platform level. This paper proposes novel strategies to address the challenges in the design of a complete monitoring system for indoor environmental quality. By adopting the proposed solution, one can reduce the data rate transfer between the monitoring devices and the server without loss of information, as well as achieve efficient data storage and aggregation on the server side to minimize retrieval times. Finally, enhanced flexibility in the dashboard for data visualization is obtained, thus enabling graph modifications without extensive coding efforts. The functionality of the developed system was assessed, with the collected data in good agreement with those from other instruments used as references.
Schedulability Analysis in Fixed-Priority Real-Time Multicore Systems with Contention
Authors: Ortiz Luis , Guasque Ana , Balbastre Patricia , Simó José , Crespo Alfons
Published: May 2024

In the scheduling of hard real-time systems on multicore platforms, significant unpredictability arises from interference caused by shared hardware resources. The objective of this paper is to offer a schedulability analysis for such systems by assuming a general model that introduces interference as a time parameter for each task. The analysis assumes constrained deadlines and is provided for fixed priorities. It is based on worst-case response time analysis, which exists in the literature for monocore systems. We demonstrate that the worst-case response time is an upper bound, and we evaluate our proposal with synthetic loads and execution on a real platform.
Towards Complex Tissues Replication: Multilayer Scaffold Integrating Biomimetic Nanohydroxyapatite/Chitosan Composites
Authors: Palazzo Barbara , Scialla Stefania , Barca Amilcare , Sercia Laura , Izzo Daniela , Gervaso Francesca , Scalera Francesca
Published: May 2024

This study explores an approach to design and prepare a multilayer scaffold mimicking interstratified natural tissue. This multilayer construct, composed of chitosan matrices with graded nanohydroxyapatite concentrations, was achieved through an in situ biomineralization process applied to individual layers. Three distinct precursor concentrations were considered, resulting in 10, 20, and 30 wt% nanohydroxyapatite content in each layer. The resulting chitosan/nanohydroxyapatite (Cs/n-HAp) scaffolds, created via freeze-drying, exhibited nanohydroxyapatite nucleation, homogeneous distribution, improved mechanical properties, and good cytocompatibility. The cytocompatibility analysis revealed that the Cs/n-HAp layers presented cell proliferation similar to the control in pure Cs for the samples with 10% n-HAp, indicating good cytocompatibility at this concentration, while no induction of apoptotic death pathways was demonstrated up to a 20 wt% n-Hap concentration. Successful multilayer assembly of Cs and Cs/n-HAp layers highlighted that the proposed approach represents a promising strategy for mimicking multifaceted tissues, such as osteochondral ones.
Comparative Analysis of Plaque Removal and Wear between Electric–Mechanical and Bioelectric Toothbrushes
Authors: Lee Jihyun , Park Hyun M. , Kim Young Wook
Published: May 2024

Effective oral care is important for maintaining a high quality of life. Therefore, plaque control can prevent the development and recurrence of periodontitis. Brushing with a toothbrush and toothpaste is a common way to remove plaque; however, excessive brushing or brushing with abrasive toothpaste can cause wear and tear on the dental crown. Hence, we aimed to quantitatively compare the plaque-removal efficiency and tooth wear of toothbrushes using the bioelectric effect (BE) with those of electric–mechanical toothbrushes. To generate the BE signal, an electronic circuit was developed and embedded in a toothbrush. Further, typodonts were coated with cultured artificial plaques and placed in a brushing simulator. A toothpaste slurry was applied, and the typodonts were eluted with tap water after brushing. The plaques of the typodonts were captured, and the images were quantified. For the tooth wear experiment, polymethyl methacrylate disk resin blocks were brushed twice a day, and the thickness of the samples was measured. Subsequently, statistical differences between the experimental toothbrushes and typical toothbrushes were analyzed. The BE toothbrush had a higher plaque-removal efficiency and could minimize tooth wear. This study suggests that the application of BE may be a new solution for oral care.
The Expression of Adipogenic Marker Is Significantly Increased in Estrogen-Treated Lipedema Adipocytes Differentiated from Adipose Stem Cells In Vitro
Authors: Al-Ghadban Sara , Isern Spencer U. , Herbst Karen L. , Bunnell Bruce A.
Published: May 2024

Lipedema is a chronic, idiopathic, and painful disease characterized by an excess of adipose tissue in the extremities. The goal of this study is to characterize the gene expression of estrogen receptors (ERα and ERβ), G protein-coupled estrogen receptor (GPER), and ER-metabolizing enzymes: hydroxysteroid 17-beta dehydrogenase (HSD17B1, 7, B12), cytochrome P450 (CYP19A1), hormone-sensitive lipase (LIPE), enzyme steroid sulfatase (STS), and estrogen sulfotransferase (SULT1E1), which are markers in Body Mass Index (BMI) and age-matched non-lipedema (healthy) and lipedema ASCs and spheroids. Flow cytometry and cellular proliferation assays, RT-PCR, and Western Blot techniques were used to determine the expression of ERs and estrogen-metabolizing enzymes. In 2D monolayer culture, estrogen increased the proliferation and the expression of the mesenchymal marker, CD73, in hormone-depleted (HD) healthy ASCs compared to lipedema ASCs. The expression of ERβ was significantly increased in HD lipedema ASCs and spheroids compared to corresponding healthy cells. In contrast, ERα and GPER gene expression was significantly decreased in estrogen-treated lipedema spheroids. CYP19A1 and LIPE gene expressions were significantly increased in estrogen-treated healthy ASCs and spheroids, respectively, while estrogen upregulated the expression of PPAR-ϒ2 and ERα in estrogen-treated lipedema-differentiated adipocytes and spheroids. These results indicate that estrogen may play a role in adipose tissue dysregulation in lipedema.
Serum Adiponectin Predicts COVID-19 Severity
Authors: Pavel Vlad , Räth Ulrich , Schmid Stephan , Krautbauer Sabrina , Keller Dennis , Amend Pablo , Müller Martina , Mester Patricia , Buechler Christa
Published: May 2024

Adiponectin is primarily known for its protective role in metabolic diseases, and it also possesses immunoregulatory properties. Elevated levels of adiponectin have been observed in various inflammatory diseases. However, studies investigating adiponectin levels in the serum of COVID-19 patients have yielded conflicting results. This study aimed to assess serum adiponectin levels in 26 healthy controls, as well as in 64 patients with moderate and 60 patients with severe COVID-19, to determine a potential association between serum adiponectin and the severity of COVID-19. Serum adiponectin levels in severe COVID-19 patients were significantly lower than in those with moderate disease and healthy controls, who exhibited similar serum adiponectin levels. Among patients with moderate disease, positive correlations were observed between serum adiponectin and C-reactive protein levels. Of note, serum adiponectin levels of severe COVID-19 cases were comparable between patients with and without dialysis or vasopressor therapy. Superinfection with bacteria did not exert a notable influence on serum adiponectin levels in patients with severe disease. Patients who were diagnosed with severe COVID-19 and vancomycin-resistant enterococci bacteremia showed a significant reduction in their serum adiponectin levels. An analysis conducted on the entire cohort, including both moderate and severe COVID-19 patients, showed that individuals who did not survive had lower serum adiponectin levels when compared to those who survived. In summary, this study highlights a decrease in serum adiponectin levels in severe COVID-19 cases, indicating the potential utility of adiponectin as an additional biomarker for monitoring disease severity in COVID-19 or critical illnesses in general.
Computational Insights into the Interplay of Mechanical Forces in Angiogenesis
Authors: Guerra Ana , Belinha Jorge , Salgado Christiane , Monteiro Fernando Jorge , Natal Jorge Renato
Published: May 2024

This study employs a meshless computational model to investigate the impacts of compression and traction on angiogenesis, exploring their effects on vascular endothelial growth factor (VEGF) diffusion and subsequent capillary network formation. Three distinct initial domain geometries were defined to simulate variations in endothelial cell sprouting and VEGF release. Compression and traction were applied, and the ensuing effects on VEGF diffusion coefficients were analysed. Compression promoted angiogenesis, increasing capillary network density. The reduction in the VEGF diffusion coefficient under compression altered VEGF concentration, impacting endothelial cell migration patterns. The findings were consistent across diverse simulation scenarios, demonstrating the robust influence of compression on angiogenesis. This computational study enhances our understanding of the intricate interplay between mechanical forces and angiogenesis. Compression emerges as an effective mediator of angiogenesis, influencing VEGF diffusion and vascular pattern. These insights may contribute to innovative therapeutic strategies for angiogenesis-related disorders, fostering tissue regeneration and addressing diseases where angiogenesis is crucial.
Burning Mouth Syndrome Treated with Low-Level Laser and Clonazepam: A Randomized, Single-Blind Clinical Trial
Authors: Garcia Martinez Ana , Lopez-Jornet Pia , Pardo Marin Luis , Pons-Fuster Eduardo , Tvarijonaviciute Asta
Published: May 2024

Objective: Burning mouth syndrome (BMS) is a chronic pain disorder characterized by intraoral burning or dysaesthetic sensation, with the absence of any identifiable lesions. Numerous treatments for BMS have been investigated, though without conclusive results. An analysis was conducted of the efficacy of treatment with a low-level diode laser and clonazepam in patients with BMS, and a study was carried out on the levels of different salivary biomarkers before and after treatment. Material and methods: A randomized, single-blind clinical trial was carried out involving 89 patients divided into the following groups: group 1 (laser, The Helbo® Theralite Laser 3D Pocket Probe + clonazepam) (n = 20), group 2 (sham laser placebo) (n = 19), group 3 (laser) (n = 21) and group 4 (clonazepam) (n = 18). Symptom intensity was scored based on a visual analogue scale (VAS). Sialometry was performed before and after treatment, and the Xerostomia Inventory, Oral Health Impact Profile-14 (OHIP-14) and Mini-Nutritional Assessment (MNA) questionnaires were administered. The following markers were measured in saliva samples: interleukins (IL2, IL4, IL5, IL6, IL7, IL8, IL1β, IL10, IL12, IL13, IL17, IL21 and IL23), proteins (MIP-3α, MIP-1α and MIP-1β), GM-CSF, interferon gamma (IFNγ), interferon-inducible T-cell alpha chemoattractant (ITAC), fractalkine and tumor necrosis factor α (TNFα). Results: A significant decrease in the VAS scores was observed after treatment in group 1 (laser + clonazepam) (p = 0.029) and group 3 (laser) (p = 0.005). In turn, group 3 (laser) showed a decrease in the salivary concentration of fractalkine (p = 0.025); interleukins IL12 (p = 0.048), IL17 (p = 0.020), IL21 (p = 0.008), IL7 (p = 0.001) and IL8 (p = 0.007); proteins MIP1α (p = 0.048) and MIP1β (p = 0.047); and TNFα (p = 0.047) versus baseline. Following treatment, group 1 (laser + clonazepam) showed significant differences in IL21 (p = 0.045) and IL7 (p = 0.009) versus baseline, while group 4 (clonazepam) showed significant differences in IL13 (p = 0.036), IL2 (p = 0.020) and IL4 (p = 0.001). No significant differences were recorded in group 2 (sham laser placebo). Conclusions: The low-level diode laser is a good treatment option in BMS, resulting in a decrease in patient symptoms and in salivary biomarkers. However, standardization of the intervention protocols and laser intensity parameters is needed in order to draw more firm conclusions.
Transient Left Ventricular Dysfunction from Cardiomyopathies to Myocardial Viability: When and Why Cardiac Function Recovers
Authors: Trimarchi Giancarlo , Teresi Lucio , Licordari Roberto , Pingitore Alessandro , Pizzino Fausto , Grimaldi Patrizia , Calabrò Danila , Liotta Paolo , Micari Antonio , de Gregorio Cesare , Di Bella Gianluca
Published: May 2024

Transient left ventricular dysfunction (TLVD), a temporary condition marked by reversible impairment of ventricular function, remains an underdiagnosed yet significant contributor to morbidity and mortality in clinical practice. Unlike the well-explored atherosclerotic disease of the epicardial coronary arteries, the diverse etiologies of TLVD require greater attention for proper diagnosis and management. The spectrum of disorders associated with TLVD includes stress-induced cardiomyopathy, central nervous system injuries, histaminergic syndromes, various inflammatory diseases, pregnancy-related conditions, and genetically determined syndromes. Furthermore, myocardial infarction with non-obstructive coronary arteries (MINOCA) origins such as coronary artery spasm, coronary thromboembolism, and spontaneous coronary artery dissection (SCAD) may also manifest as TLVD, eventually showing recovery. This review highlights the range of ischemic and non-ischemic clinical situations that lead to TLVD, gathering conditions like Tako-Tsubo Syndrome (TTS), Kounis syndrome (KS), Myocarditis, Peripartum Cardiomyopathy (PPCM), and Tachycardia-induced cardiomyopathy (TIC). Differentiation amongst these causes is crucial, as they involve distinct clinical, instrumental, and genetic predictors that bode different outcomes and recovery potential for left ventricular function. The purpose of this review is to improve everyday clinical approaches to treating these diseases by providing an extensive survey of conditions linked with TLVD and the elements impacting prognosis and outcomes.
Clap-and-Fling Mechanism of Climbing-Flight Coccinella Septempunctata
Authors: Yang Lili , Deng Huichao , Hu Kai , Ding Xilun
Published: May 2024

Previous studies on the clap–fling mechanism have predominantly focused on the initial downward and forward phases of flight in miniature insects, either during hovering or forward flight. However, this study presents the first comprehensive kinematic data of Coccinella septempunctata during climbing flight. It reveals, for the first time, that a clap-and-fling mechanism occurs during the initial upward and backward phase of the hind wings’ motion. This discovery addresses the previously limited understanding of the clap-and-fling mechanism by demonstrating that, during the clap motion, the leading edges of beetle’s wings come into proximity to form a figure-eight shape before rotating around their trailing edge to open into a “V” shape. By employing numerical solutions to solve Navier–Stokes (N-S) equations, we simulated both single hind wings’ and double hind wings’ aerodynamic conditions. Our findings demonstrate that this fling mechanism not only significantly enhances the lift coefficient by approximately 9.65% but also reduces the drag coefficient by about 1.7%, indicating an extension of the applicability range of this clap-and-fling mechanism beyond minute insect flight. Consequently, these insights into insect flight mechanics deepen our understanding of their biological characteristics and inspire advancements in robotics and biomimetics.
How Financial Beliefs and Behaviors Influence the Financial Health of Individuals Struggling with Opioid Use Disorder
Authors: Langabeer James R. , Vega Francine R. , Cardenas-Turanzas Marylou , Cohen A. Sarah , Lalani Karima , Champagne-Langabeer Tiffany
Published: May 2024

The surge in opioid use disorder (OUD) over the past decade escalated opioid overdoses to a leading cause of death in the United States. With adverse effects on cognition, risk-taking, and decision-making, OUD may negatively influence financial well-being. This study examined the financial health of individuals diagnosed with OUD by reviewing financial beliefs and financial behaviors. We evaluated quality of life, perceptions of financial condition during active use and recovery, and total debt. We distributed a 20-item survey to 150 individuals in an outpatient treatment program for OUD in a large metropolitan area, yielding a 56% response rate. The results revealed low overall financial health, with a median debt of USD 12,961 and a quality-of-life score of 72.80, 9.4% lower than the U.S. average (82.10). Most participants (65.75%) reported improved financial health during recovery, while a higher majority (79.45%) worsened during active use. Unemployment affected 42% of respondents, and 9.52% were employed only part-time. Regression analysis highlighted a strong association between lack of full-time employment and a lack of financial advising with total debt. High financial anxiety and active use were associated with lower quality of life. Individuals with OUD may benefit from financial interventions, resources, and counseling to improve their financial health.
Exploring the Impact of Campus Landscape Visual Elements Combination on Short-Term Stress Relief among College Students: A Case from China
Authors: He Hui , Zhang Tong , Zhang Qinghao , Rong Sheng , Jia Yihe , Dong Fengqian
Published: May 2024

Although the effect of campus landscape space on stress relief among college students has been confirmed, few existing studies have considered the impact on stress recovery from the perspective of factor combination, and the key visual elements and the most effective combination of visual elements to relieve stress are still unclear. This study attempts to conduct a natural experiment within Chinese campuses, measuring physiological indicators of stress such as heart rate (HR), frequency domain index of heart rate variability (LF/HF), skin conductance level (SCL), skin temperature (SKT), and respiratory rate (RESP) using physiological instruments. It explored the effects of visual elements and their combinations in campus landscape spaces on short-term stress relief among college students through semantic segmentation, multifactorial analysis of variance, and post hoc multiple comparison methods. Research results demonstrate that the presence of water elements in the field of vision can effectively improve the stress relief effects of landscape spaces. Reasonable combinations of natural landscape elements and artificial landscape elements in the design can also effectively promote stress relief among students. Building facade area and sky area, water area and sky area, and plant species and pavement area are three combinations of factors with the strongest interactive effects. “Natural water scenery” and “exquisite artificial” are two campus landscape design patterns most conducive to short-term stress relief.
Development of a Systematic Approach for the Assessment of Adhesive Tape Suitability to Ensure Airtightness
Authors: Jucienė Milda , Dobilaitė Vaida , Kumžienė Jurga , Banionis Karolis , Paukštys Valdas , Stonkuvienė Aurelija
Published: May 2024

Ensuring the tightness of buildings using self-adhesive tapes is one of the cost-effective, efficient, and reliable solutions. There is a lack of research, standards, and methodologies for construction adhesive tape, especially for assessing the functional properties of the tape after ageing. The aim of this work is to evaluate the tightness of different building surfaces and adhesive tape systems by conducting artificial ageing. It was found that adhesive tapes with an acrylic adhesive base ensured a fully sealed system. In all cases, tapes applied to surfaces such as plywood, gypsum plasterboard, cement-bonded particle board, plastered cement-bonded particle board, and plastic board provided sufficient sealing. The air permeability of the tapes on the OSB was two to seven times higher than that of the defined sealed system with other surfaces. In most cases, air permeability increased on OSB, gypsum plasterboard, and plastered cement-bonded particle board after ageing. The least problematic surface is the plastic board. In all tested cases, adequate sealing was observed after ageing, with only three of all tested tapes not providing sufficient bonding strength.
Evolutionary Algorithms for Strength Prediction of Geopolymer Concrete
Authors: Huang Bingzhang , Bahrami Alireza , Javed Muhammad Faisal , Azim Iftikhar , Iqbal Muhammad Ayyan
Published: May 2024

Geopolymer concrete (GPC) serves as a sustainable substitute for conventional concrete by employing alternative cementitious materials such as fly ash (FA) instead of ordinary Portland cement (OPC), contributing to environmental and durability benefits. To increase the rate of utilization of FA in the construction industry, distinctive characteristics of two machine learning (ML) methods, namely, gene expression programming (GEP) and multi-expression programming (MEP), were utilized in this study to propose precise prediction models for the compressive strength and split tensile strength of GPC comprising FA as a binder. A comprehensive database was collated, which comprised 301 compressive strength and 96 split tensile strength results. Seven distinct input variables were employed for the modeling purpose, i.e., FA, sodium hydroxide, sodium silicate, water, superplasticizer, and fine and coarse aggregates contents. The performance of the developed models was assessed via numerous statistical metrics and absolute error plots. In addition, a parametric analysis of the finalized models was performed to validate the prediction ability and accuracy of the finalized models. The GEP-based prediction models exhibited better performance, accuracy, and generalization capability compared with the MEP-based models in this study. The GEP-based models demonstrated higher correlation coefficients (R) for predicting the compressive and split tensile strengths, with the values of 0.89 and 0.87, respectively, compared with the MEP-based models, which yielded the R values of 0.76 and 0.73, respectively. The mean absolute errors for the GEP- and MEP-based models for predicting the compressive strength were 5.09 MPa and 6.78 MPa, respectively, while those for the split tensile strengths were 0.42 MPa and 0.51 MPa, respectively. The finalized models offered simple mathematical formulations using the GEP and Python code-based formulations from MEP for predicting the compressive and tensile strengths of GPC. The developed models indicated practical application potential in optimizing geopolymer mix designs. This research work contributes to the ongoing efforts in advancing ML applications in the construction industry, highlighting the importance of sustainable materials for the future.
A Calculation Method for Reliability Index of a Deep–Bedded Karst Tunnel Construction with Cavity Located Ahead of Tunnel Working Face
Authors: Wu Bo , Sun Wentao , Meng Guowang
Published: May 2024

For the purpose of reliability quantitative assessment of the surrounding rock of the deeply embedded karst tunnel and the geological body around the cavern in the case of the cavern in the forepart of the tunnel face, on the basis of the upper bound limit analysis method, the energy dissipation theory, as well as the reliability theory, the dimensionless performance function of each damage area of the deeply buried karst tunnels could be established in the case of the cavern in the front of the tunnel face. Subsequently, the probability of failure and the reliability index of each damage region of the deep–bedded karst tunnel in the case of the cavern in the front of this tunnel face should be calculated through the Monte Carlo simulation sampling approach. The investigation has demonstrated that the larger the cohesion of the geotechnical body and the larger the internal friction angle within the geotechnical body, the larger the reliability indexes of the geotechnical bodies around the tunnel. The larger the diameter of the cavern and the larger the tunnel burial depth, the greater the probability of failure in the left part of the geotechnical body around this cavern, and the smaller the reliability indexes of these damage areas.
Digitization of AEC Industries Based on BIM and 4.0 Technologies
Authors: Zawada Karol , Rybak-Niedziółka Kinga , Donderewicz Mikołaj , Starzyk Agnieszka
Published: May 2024

BIM and 4.0 technologies are currently the leading branches of digitization in construction. The aim of this article is to confront theses on building information modeling (BIM) and coexisting technologies, and to present an analysis along with conclusions regarding the digitization process of AEC industries using BIM methodology and advanced digital technologies within the scope of 4.0 technologies. Key aspects of BIM and 4.0 technology integration were discussed, including artificial intelligence (AI) or big data and data science analytics. The impact of these fields on design processes, as well as on data management, monitoring of design and construction progress, and overall efficiency of AEC industries, was analyzed. The article pays particular attention to the synergy between BIM and 4.0 technology, identifying benefits, challenges, and development perspectives. Conclusions indicate the growing importance of interdisciplinarity for improving AEC industry processes and the need to adapt to the changing digital landscape in the field of design and construction. A survey was conducted, where respondents’ answers were presented in the form of charts. Questions focused on the issue of the use of BIM methodology along with coexisting technologies in the design process by the Polish engineering staff. The research results indicate that the use of the latest technological solutions in Poland is still rare, and the digital potential of these solutions is not fully utilized. The article can make a significant contribution to the discussion on technological evolution in AEC industries, identifying development directions in the context of digitization and the use of the latest achievements of 4.0 technology. Previous research has not included such a wide spectrum of BIM use in Poland. An analysis was conducted comparing Poland in a global context with other countries in BIM adoption.
Systemic DNA Damage and Repair Activity Vary by Race in Breast Cancer Survivors
Authors: Divekar Shraddha , Kritzer Ryan , Shu Haokai , Thakkar Keval , Hicks Jennifer , Mills Mary G. , Makambi Kepher , Dash Chiranjeev , Roy Rabindra
Published: May 2024

Non-Hispanic Black breast cancer survivors have poorer outcomes and higher mortality rates than White survivors, but systemic biological mechanisms underlying these disparities are unclear. We used circulating leukocytes as a surrogate for measuring systemic mechanisms, which might be different from processes in the target tissue (e.g., breast). We investigated race-based differences in DNA damage and repair, using a novel CometChip assay, in circulating leukocytes from breast cancer survivors who had completed primary cancer therapy and were cancer free. We observed novel race-based differences in systemic DNA damage and repair activity in cancer survivors, but not in cells from healthy volunteers. Basal DNA damage in leukocytes was higher in White survivors, but Black survivors showed a much higher induction after bleomycin treatment. Double-strand break repair activity was also significantly different between the races, with cells from White survivors showing more sustained repair activity compared to Black leukocytes. These results suggest that cancer and cancer therapy might have long-lasting effects on systemic DNA damage and repair mechanisms that differ in White survivors and Black survivors. Findings from our preliminary study in non-cancer cells (circulating leukocytes) suggest systemic effects beyond the target site, with implications for accelerated aging-related cancer survivorship disparities.
Impact of Nutritional Status on Neutrophil-to-Lymphocyte Ratio as a Predictor of Efficacy and Adverse Events of Immune Check-Point Inhibitors
Authors: Sue Masahiko , Takeuchi Yasuto , Hirata Shoichiro , Takaki Akinobu , Otsuka Motoyuki
Published: May 2024

The neutrophil -to-lymphocyte ratio (NLR) is useful for predicting the effectiveness of treatment with immune checkpoint inhibitors (ICIs) and immune-related adverse events (irAEs). Because a growing body of evidence has recently shown that the number of lymphocytes that comprise NLR fluctuates according to nutritional status, this study examined whether the usefulness of NLR varies in ICI treatment due to changes in nutritional status. A retrospective analysis was performed on 1234 patients who received ICI treatment for malignant tumors at our hospital. Progression-free survival (PFS) was significantly prolonged in patients with NLR < 4. Multivariate analysis revealed that the factors associated with the occurrence of irAE were NLR < 4 and the use of ipilimumab. However, when limited to cases with serum albumin levels <3.8 g/dL, lymphocyte counts significantly decreased, and the associations between NLR and PFS and between NLR and irAE occurrence disappeared. In contrast, when limited to the cases with serum albumin levels ≥3.8 g/dL, the associations remained, with significantly prolonged PFS and significantly increased irAE occurrence at NLR < 4. NLR may be a good predictive tool for PFS and irAE occurrence during ICI treatment when a good nutritional status is maintained.
A Highly Sensitive Molecular Technique for RNA Virus Detection
Authors: Rozmyslowicz Tomasz , Arévalo-Romero Haruki , Conover Dareus O. , Fuentes-Pananá Ezequiel M. , León-Juárez Moisés , Gaulton Glen N.
Published: May 2024

Zika (ZIKV) and Chikungunya (CHIKV) viruses are mosquito-transmitted infections, or vector-borne pathogens, that emerged a few years ago. Reliable diagnostic tools for ZIKV and CHIKV—inexpensive, multiplexed, rapid, highly sensitive, and specific point-of-care (POC) systems—are vital for appropriate risk management and therapy. We recently studied a detection system with great success in Mexico (Villahermosa, state of Tabasco), working with human sera from patients infected with those viruses. The research conducted in Mexico validated the efficacy of a novel two-step rapid isothermal amplification technique (RAMP). This approach, which encompasses recombinase polymerase amplification (RPA) followed by loop-mediated isothermal amplification (LAMP), had been previously established in the lab using lab-derived Zika (ZIKV) and Chikungunya (CHIKV) viruses. Crucially, our findings confirmed that this technique is also effective when applied to human sera samples collected from locally infected individuals in Mexico.
Exogenous Metabolic Modulators Improve Response to Carboplatin in Triple-Negative Breast Cancer
Authors: Ho Alyssa N. , Kiesel Violet A. , Gates Claire E. , Brosnan Bennett H. , Connelly Scott P. , Glenny Elaine M. , Cozzo Alyssa J. , Hursting Stephen D. , Coleman Michael Francis
Published: May 2024

Triple-negative breast cancer (TNBC) lacks targeted therapies, leaving cytotoxic chemotherapy as the current standard treatment. However, chemotherapy resistance remains a major clinical challenge. Increased insulin-like growth factor 1 signaling can potently blunt chemotherapy response, and lysosomal processes including the nutrient scavenging pathway autophagy can enable cancer cells to evade chemotherapy-mediated cell death. Thus, we tested whether inhibition of insulin receptor/insulin-like growth factor 1 receptor with the drug BMS-754807 and/or lysosomal disruption with hydroxychloroquine (HCQ) could sensitize TNBC cells to the chemotherapy drug carboplatin. Using in vitro studies in multiple TNBC cell lines, in concert with in vivo studies employing a murine syngeneic orthotopic transplant model of TNBC, we show that BMS-754807 and HCQ each sensitized TNBC cells and tumors to carboplatin and reveal that exogenous metabolic modulators may work synergistically with carboplatin as indicated by Bliss analysis. Additionally, we demonstrate the lack of overt in vivo toxicity with our combination regimens and, therefore, propose that metabolic targeting of TNBC may be a safe and effective strategy to increase sensitivity to chemotherapy. Thus, we conclude that the use of exogenous metabolic modulators, such as BMS-754807 or HCQ, in combination with chemotherapy warrants additional study as a strategy to improve therapeutic responses in women with TNBC.