bluuebunny/crossref_metadata_2025 huggingface dataset:
Moving forward in Rheumatoid Arthritis-Associated Interstitial Lung Disease Screening
Authors: Narváez Javier
Published: September 2024

Patients with rheumatoid arthritis (RA) are at increased risk of developing interstitial lung disease compared to the general population, a complication that is associated with significant morbidity and high mortality. Given its frequency and severity, ILD should always be considered during both the initial assessment and follow-up of RA patients. However, there is currently no consensus on which RA patients should be screened for ILD. In recent years, several scientific societies have developed specific screening proposals. According to the recommendations of the Spanish, American, and Austrian rheumatology societies, it is not necessary to screen all individuals with RA, and it should be tailored to each patient based on clinical risk factors. In contrast, the Portuguese Societies of Rheumatology and Pulmonology advocate for systematic screening of all RA patients. Risk factors for the development of ILD in RA patients are well identified, and several screening tools for RA-ILD based on these risk factors have been developed. However, all of these tools still require further validation. To address this issue, the ANCHOR-RA study, a multinational cross-sectional initiative, has been launched to develop a multivariable model for predicting RA-ILD, which could provide valuable guidance for screening practices in clinical settings. In addition to certain biochemical and genetic predictive markers, lung ultrasound appears to be a useful screening tool. When combined with clinical evaluation and risk factor assessment, it can help identify which patients require a thoracic HRCT evaluation, which remains the gold standard for confirming an ILD diagnosis.
Association of Evening Shifts, Night Shifts, and Consistent Overtime Exceeding 10 Hours per Day with Sudden Cardiac Arrest: A Case–Control Study
Authors: Ha Seung Won , Ryoo Seung Mok , Kim Sang-Min , Kim June-Sung , Kwon Hyojeong , Park Hanna , Kim Dongju , Kim Won Young
Published: September 2024

Background: We investigated the relationship between employment status, work patterns, and sudden cardiac arrest (SCA). Methods: This was a case–control study from September 2017 through December 2022 involving 17 emergency departments and 9 public health centers. The cases included patients aged 20–79 years with SCA, excluding those with traumatic arrest, terminal illness, pregnancy, unreliable information, or a “Do Not Resuscitate” order. Controls were selected from various health screening centers in Korea. All participants completed structured questionnaires. Propensity score matching was used to ensure comparability by age, sex, and socioeconomic status. Results: Of the 1536 patients enrolled, 116 from the case group were excluded due to missing employment data, leaving 1420 cases and 2304 controls for analysis. Employment was reported by 47.5% of cases and 59.4% of controls. There was no significant difference in the proportion of sole proprietors (20.6% vs. 22.5%, p = 0.39). The case group had a higher proportion of employers (13.2% vs. 6.5%, p < 0.001) and fewer employees (63.3% vs. 69.1%, p = 0.02). Professional roles were more common among controls (23.6% vs. 31.6%, p < 0.001), while labor-intensive jobs were more frequent in cases (27.7% vs. 17.8%, p < 0.001). The case group had more evening and night shifts (odds ratio [OR]: 1.04, 95% confidence interval [CI]: 1.01–1.06; OR: 1.05, 95% CI: 1.01–1.09) and longer workdays (OR: 1.06, 95% CI: 1.03–1.08). Conclusions: SCA patients were more likely to work evening and night shifts and have longer workdays, often exceeding 10 h.
Outcomes and Patterns of Evolution of Patients with Hematological Malignancies during the COVID-19 Pandemic: A Nationwide Study (2020–2022)
Authors: Garcia-Carretero Rafael , Ordoñez-Garcia Maria , Gil-Prieto Ruth , Gil-de-Miguel Angel
Published: September 2024

Background: Early reports suggest that hematological malignancy (HM) is a relevant risk factor for morbidity and mortality in COVID-19. We investigated the characteristics, outcomes, and risk factors for mortality in patients hospitalized with HM and COVID-19. Methods: We conducted a retrospective, nationwide study using data from hospitalized patients that were provided by the Spanish Ministry of Health including all patients admitted to a Spanish hospital from 2020 to 2022 with a COVID-19 diagnosis. A descriptive analysis and correlational analyses were conducted. Logistic regression was used to assess mortality in these patients and to calculate odds ratios (ORs). Results: We collected data on 1.2 million patients with COVID-19, including 34,962 patients with HMs. The incidence of hospitalization for patients with HMs was 5.8%, and the overall mortality rate was higher than for patients without HMs (19.8% versus 12.7%, p = 0.001). Mortality rates were higher for patients with lymphomas, multiple myelomas, and leukemias than for those with myeloproliferative disorders. Having HMs was a risk factor for mortality, with OR = 1.7 (95% CI 1.66–1.75, p = 0.001). By subtype, non-Hodgkin lymphomas were the highest risk factor for mortality (OR = 1.7), followed by leukemias (OR = 1.6), Hodgkin lymphomas (OR = 1.58), and plasma cell dyscrasias (OR = 1.24). Conclusions: This study identifies the different clinical profiles of patients with HMs who are at a high risk for mortality when hospitalized with COVID-19. As members of a vulnerable population, these patients deserve special prophylactic and therapeutic measures to minimize the effects of SARS-CoV-2 infection.
Pulmonary Manifestations of IBD: Case Report and Review of the Literature
Authors: Herling Amit , Perluk Tal Moshe , Freund Ophir , Maharshak Nitsan , Cohen Nathaniel Aviv
Published: September 2024

This article explores the pulmonary complications associated with inflammatory bowel disease (IBD). It presents a detailed case study of a 22-year-old male with Crohn’s disease exhibiting pulmonary symptoms. The review delves into the spectrum of pulmonary involvement in IBD, covering clinical presentations, diagnostic challenges, underlying pathophysiology, and management strategies. It highlights the significance of these extraintestinal manifestations on patient outcomes and quality of life. The article underscores the need for heightened clinical awareness and a systematic approach to diagnosis and management, integrating the expertise of multiple specialists. The review identifies gaps in current research, suggesting avenues for future investigation to enhance the understanding and treatment of these complex manifestations.
Real-World Impact of GLP-1 Receptor Agonists on Endoscopic Patient Outcomes in an Ambulatory Setting: A Retrospective Study at a Large Tertiary Center
Authors: Robalino Gonzaga Ernesto , Farooq Aimen , Mohammed Abdul , Chandan Saurabh , Fawwaz Baha , Singh Gurdeep , Malik Amna , Zhang Yiyang , Kadkhodayan Kambiz
Published: September 2024

Background: Glucagon-like peptide receptor agonists (GLP-1 RAs) are associated with delayed gastric emptying and may increase the risk of aspiration due to retained gastric contents. There are no guidelines on peri-endoscopic use of GLP-1 RAs, and real-world outcomes in an ambulatory setting remain unknown. This study reports real-world data from an ambulatory center associated with a large tertiary hospital. Methods: A retrospective review of electronic medical records was conducted for patients who underwent esophagogastroduodenoscopy (EGD) at a hospital-based outpatient center from January to June 2023. Exclusions included non-elective procedures, current opioid use, altered foregut anatomy, and known gastroparesis. All patients were on GLP-1 RAs before endoscopy and followed standard fasting protocols. Adverse event rates were recorded, and patients were divided into cohorts based on GLP-1 RA use. Univariate and multivariate regression analyses identified risk factors for food retention and complications. Results: A total of 1438 patients underwent elective EGD during the study period. Among the 1046 patients included, 73 (7%) were on GLP-1 RAs. The procedure was aborted in four patients (0.4%) due to gastric food retention, with two (50%) on GLP-1 RAs. Independent risk factors for food retention included GLP-1 RA use (OR: 9.19; 95% CI: 2.73–30.8; p = 0.0003) and diabetes (OR 5.6; 95% CI: 1.72–18.2; p = 0.004). Tirzepatide showed the strongest association (p = 0.0056). Factors that did not impact food retention included A1c, BMI, and gender. Protective factors were age (OR 0.96; 95% CI: 0.93–0.99; p = 0.02) and same-day colonoscopy (OR 0.18; 95% CI: 0.06–0.58; p = 0.003). Conclusions: GLP-1 RA use in diabetics increases the risk of retained gastric contents during elective EGD, particularly with tirzepatide, without increasing aspiration risk. Patients undergoing simultaneous colonoscopy had a lower risk of retained gastric contents. Further studies are needed to evaluate the impact of GLP-1 RAs on gastric food retention and procedural risk.
A Scoping Review of Technology-Based Approaches for Upper Limb Motor Rehabilitation after Stroke: Are We Really Targeting Severe Impairment?
Authors: Colamarino Emma , Morone Giovanni , Toppi Jlenia , Riccio Angela , Cincotti Febo , Mattia Donatella , Pichiorri Floriana
Published: September 2024

Technology-based approaches for upper limb (UL) motor rehabilitation after stroke are mostly designed for severely affected patients to increase their recovery chances. However, the available randomized controlled trials (RCTs) focused on the efficacy of technology-based interventions often include patients with a wide range of motor impairment. This scoping review aims at overviewing the actual severity of stroke patients enrolled in RCTs that claim to specifically address UL severe motor impairment. The literature search was conducted on the Scopus and PubMed databases and included articles from 2008 to May 2024, specifically RCTs investigating the impact of technology-based interventions on UL motor functional recovery after stroke. Forty-eight studies were selected. They showed that, upon patients’ enrollment, the values of the UL Fugl-Meyer Assessment and Action Research Arm Test covered the whole range of both scales, thus revealing the non-selective inclusion of severely impaired patients. Heterogeneity in terms of numerosity, characteristics of enrolled patients, trial design, implementation, and reporting was present across the studies. No clear difference in the severity of the included patients according to the intervention type was found. Patient stratification upon enrollment is crucial to best direct resources to those patients who will benefit the most from a given technology-assisted approach (personalized rehabilitation).
Neurofilament Light Chain as Biomarker in Encephalitis
Authors: Wellmann Sven , Geis Tobias , Kuhle Jens , Lehnerer Verena
Published: September 2024

Inflammation of the brain is called encephalitis and may result in acute and chronic brain damage. Encephalitis can be caused by various pathogens, especially neurotropic viruses, or can occur in the context of autoimmune diseases. Encephalitis is often difficult to diagnose and to monitor precisely during the course of the disease. Thanks to highly specific detection technology, components of the neuron skeleton, such as neurofilaments, can now be reliably quantified in the peripheral blood besides cerebrospinal fluid (CSF). Among them, neurofilament light chain (NfL) has demonstrated wide utility due to high preanalytical stability, robust diagnostic technology, and excellent reproducibility. We provide an overview of how NfL has advanced diagnostics in encephalitis and outline future avenues in research needs and possible clinical applicability of NfL in adults and children.
Can AI Predict the Magnitude and Direction of Ortho-K Contact Lens Decentration to Limit Induced HOAs and Astigmatism?
Authors: Lin Wen-Pin , Wu Lo-Yu , Li Wen-Kai , Lin Wei-Ren , Wu Richard , White Lynn , Abass Rowan , Alanazi Rami , Towler Joseph , Davies Jay , Abass Ahmed
Published: September 2024

Background: The aim is to investigate induced higher-order aberrations (HOA)s and astigmatism as a result of non-toric ortho-k lens decentration and utilise artificial intelligence (AI) to predict its magnitude and direction. Methods: Medmont E300 Video topographer was used to scan 249 corneas before and after ortho-k wear. Custom-built MATLAB codes extracted topography data and determined lens decentration from the boundary and midpoint of the central flattened treatment zone (TZ). An evaluation was carried out by conducting Zernike polynomial fittings via a computer-coded digital signal processing procedure. Finally, an AI-based machine learning neural network algorithm was developed to predict the direction and magnitude of TZ decentration. Results: Analysis of the first 21 Zernike polynomial coefficients indicate that the four low-order and four higher-order aberration terms were changed significantly by ortho-k wear. While baseline astigmatism was not correlated with lens decentration (R = 0.09), post-ortho-k astigmatism was moderately correlated with decentration (R = 0.38) and the difference in astigmatism (R = 0.3). Decentration was classified into three groups: ≤0.50 mm, reduced astigmatism by −0.9 ± 1 D; 0.5~1 mm, increased astigmatism by 0.8 ± 0.1 D; >1 mm, increased astigmatism by 2.7 ± 1.6 D and over 50% of lenses were decentred >0.5 mm. For lenses decentred >1 mm, 29.8% of right and 42.7% of left lenses decentred temporal-inferiorly and 13.7% of right and 9.4% of left lenses decentred temporal-superiorly. AI-based prediction successfully identified the decentration direction with accuracies of 70.2% for right and 71.8% for left lenses and predicted the magnitude of decentration with root-mean-square (RMS) of 0.31 mm and 0.25 mm for right and left eyes, respectively. Conclusions: Ortho-k lens decentration is common when fitting non-toric ortho-k lenses, resulting in induced HOAs and astigmatism, with the magnitude being related to the amount of decentration. AI-based algorithms can effectively predict decentration, potentially allowing for better control over ortho-k fitting and, thus, preferred clinical outcomes.
Altered Movement Coordination during Functional Reach Tasks in Patients with Chronic Low Back Pain and Its Relationship to Numerical Pain Rating Scores
Authors: van der Veen Susanne M. , France Christopher R. , Thomas James S.
Published: September 2024

Identifying the effects of pain catastrophizing on movement patterns in people with chronic low back pain (CLBP) has important clinical implications for treatment approaches. Prior research has shown people with CLBP have decreased lumbar-hip ratios during trunk flexion movements, indicating a decrease in the contribution of lumbar flexion relative to hip flexion during trunk flexion. In this study, we aim to explore the relationship between pain catastrophizing and movement patterns during trunk flexion in a CLBP population. Participants with CLBP (N = 98, male = 59, age = 39.1 ± 13.0) completed a virtual reality standardized reaching task that necessitated a progressively larger amount of trunk flexion. Specifically, participants reached for four virtual targets to elicit 15°, 30°, 45°, and 60° trunk flexion in the mid-sagittal plane. Lumbar flexion was derived from the motion data. Self-report measures of numerical pain ratings, kinesiophobia, and pain catastrophizing were obtained. Pain catastrophizing leads to decreased lumbar flexion angles during forward reaching. This effect is greater in females than males.
Exposure of Carboniferous Granitoids on Triassic–Jurassic Seashores in the Western Caucasus: A Stratigraphical Review
Authors: Ruban Dmitry A.
Published: September 2024

Granitoids are known to crop out on ancient seashores, but the related geological evidence remains limited. The information from the Western Caucasus sheds light on the stratigraphical distribution of coarse siliciclastic beds associated with late Carboniferous granitoids of the Dakh, Rafabgo, and Sakhray crystalline massifs. For the purposes of this study, the available information was reviewed and verified against the modern stratigraphical scales. It is established that the considered coarse sisliciclastic beds occur at five stratigraphical levels of the Triassic–Jurassic succession. A rocky seashore with granitoid exposures existed for a short time around the Sakhray and probably Rufabgo massifs at the very beginning of the Triassic. The Dakh Massif possessed such a shore twice (at least), i.e., in the Norian–Rhaetian and the Early Toarcian. However, it cannot be excluded that rocky shores persisted there for >50 Ma. Generally, the Western Caucasus provides an example of granitoid exposures on Mesozoic seashores and adds knowledge of the global distribution of rocky shores in the Triassic and Jurassic periods.
A Molecular Dynamics Study of the Influence of Low-Dosage Methanol on Hydrate Formation in Seawater and Pure Water Metastable Solutions of Methane
Authors: Belosludov Rodion V. , Gets Kirill V. , Zhdanov Ravil K. , Bozhko Yulia Y. , Belosludov Vladimir R.
Published: September 2024

The behavior of low concentrations of methanol (0.5 and 1.0 wt% of water) as a promoter for hydrate formation in seawater or pure water metastable solutions of methane was investigated using the classical molecular dynamics method at moderate temperature and pressure. The influence of methanol on the dynamics of the re-arrangement of the hydrogen bond network in seawater and pure water solutions of methane was studied by calculating order parameters of the tetrahedral environment and intermolecular torsion angles for water molecules, as well as by calculating the number of hydrogen bonds, hydrate, and hydrate-like cavities. It was found that hydrate nucleation can be considered a collective process in which the rate of hydrate growth is faster in systems with low concentrations of methanol, and confident hydrate growth begins earlier in a metastable solution without sea salt with a small amount of methanol than in systems without methanol.
Exploration of the Pulsation Characteristics of a Bubble Adjacent to the Structure with Multiple Air Bubble Adhesions
Authors: Jiang Mingzuo , Liu Kun , Wang Jiaxia , Zhao Xiaojie , Wu Shizeng
Published: September 2024

The dynamics of bubbles have garnered extensive interest among researchers both domestically and internationally due to their applications in engineering and military fields. The exploration of the mechanisms behind bubble loading, cavitation damage, and impact destruction has always been a focal point of study. However, in practical applications, bubbles often do not occur in isolation, and the interactions between multiple bubbles are highly complex. Therefore, this study investigates the pulsation characteristics of bubbles near rigid boundaries with multiple air bubbles attached in different spatial arrangements, focusing on the coupled pulsation phenomenon between cavitation clusters and bubbles. The research indicates that this coupled pulsation phenomenon is primarily influenced by the dimensionless distance parameter γs from the bubble to the boundary, the spacing γL between the air bubbles, and the spatial arrangement. Compared to Layout II, the bubble exhibits off-axis migration and jet direction only under Layout I conditions; for spatial Layout I, when the air bubble spacing γL is fixed, the displacement of the air bubble directly above the bubble is proportional to the distance parameter γs. This research underscores the potential for mitigating cavitation-induced damage through the strategic adhesion of multiple air bubbles.
The Effect of Ionizing Irradiation on the Autotaxin-Lysophasphatidic Acid Axis and Interleukin-6/8 Secretion in Different Breast Cancer Cell Lines
Authors: Promny Theresa , Scherrer Isabell , Kadam Sheetal , Schmid Rafael , Jost Tina , Distel Luitpold V. , Arkudas Andreas , Horch Raymund E. , Kengelbach-Weigand Annika
Published: September 2024

Background: The Autotaxin (ATX)-lysophosphatidic acid (LPA) axis is involved in decreasing radiation sensitivity of breast tumor cells. This study aims to further elucidate the effect of irradiation on the ATX-LPA axis and cytokine secretion in different breast cancer cell lines to identify suitable breast cancer subtypes for targeted therapies. Methods: Different breast cancer cell lines (MCF-7 (luminal A), BT-474 (luminal B), SKBR-3 (HER2-positive), MDA-MB-231 and MDA-MB-468 (triple-negative)) and the breast epithelial cell line MCF-10A were irradiated. The influence of irradiation on LPA receptor (LPAR) expression, ATX expression, and Interleukin (IL)-6 and IL-8 secretion was analyzed. Further, the effect of IL-6 and IL-8 on ATX expression of adipose-derived stem cells (ADSC) was investigated. Results: Irradiation increased ATX and LPAR2 expression in MDA-MB-231 cells. Additionally, IL-6 secretion was enhanced in MDA-MB-231, and IL-8 secretion in MDA-MB-231 and MDA-MB-468. Stimulation of ADSC with IL-6 and IL-8 increased ATX expression in ADSC. Conclusions: Targeting ATX or its downstream signaling pathways might enhance the sensitivity of triple-negative breast cancer cells to radiation. Further exploration of the interplay between irradiation, the ATX-LPA axis, and inflammatory cytokines may elucidate novel pathways for overcoming radioresistance and improving individual treatment outcomes.
Development and Application of an Environmental Vulnerability Index (EVI) for Identifying Priority Restoration Areas in the São Francisco River Basin, Brazil
Authors: Coelho Clívia Dias , da Silva Demetrius David , Amorim Ricardo Santos Silva , Vasconcelos Bruno Nery Fernandes , Possato Ernani Lopes , Filho Elpídio Inácio Fernandes , Brandão Pedro Christo , Ferreira Neto José Ambrósio , Silva Lucas Vieira
Published: September 2024

The environmental vulnerability diagnosis of a river basin depends on a holistic analysis of its environmental aspects and degradation factors. Based on this diagnosis, the definition of priority areas where interventions for environmental recovery should be carried out is fundamental, since financial and natural resources are limited. In this study, we developed a methodology to assess these fragilities using an environmental vulnerability index (EVI) that combines physical and environmental indicators related to the natural sensitivity of ecosystems and their exposure to anthropogenic factors. The developed EVI was applied to the headwater region of the São Francisco River Basin (SFRB), Brazil. The proposed index was based on the AHP multicriteria analysis and was adapted to include four variables representative of the study area: Land Use Adequacy, Burned Area, Erosion Susceptibility, and quantitative water balance. The EVI analysis highlighted that the presence of easily erodible soils, associated with sloping areas and land use above their capacity, generate the most vulnerable areas in the headwaters of the SFRB. The highest EVI values are primarily linked to regions with shallow, easily erodible soils like Leptosols and Cambisols, found in steep areas predominantly used for pasture. In the SFBR, the greatest vulnerability was observed within a 5 km buffer around conservation units, covering approximately 32.4% of the total area. The results of this study indicate where resources should be applied for environmental preservation in the basin under study, directing the allocation of efforts to areas with lower resilience to maintain ecosystem services.
The Interplay between Dietary Habits and Glycemic Control in Type 1 Diabetes: A Comprehensive Prospective FGM Study
Authors: Gradinjan Centner Maja , Čačić Kenjerić Daniela , Schönberger Ema , Centner Hrvoje , Sladić Rimac Daria , Steiner Kristina , Marušić Romana , Bakula Miro , Fabris Vitković Daniela , Mihaljević Ivica , Ćurčić Ines Bilić , Canecki Varžić Silvija
Published: September 2024

Type 1 diabetes has become prevalent among the adult population, who have increasingly gained access to sensing technology. This study delved into the impact of diet, nutritional status, and the use of a continuous glucose monitoring system (CGM) on glycemic regulation among adults diagnosed with T1D. Employing a prospective design, data were gathered from 151 participants aged 18–60 across multiple cycles. Participants utilized the FreeStyle Libre (FSL) Flash Glucose Monitoring (FGM) System and provided dietary details via questionnaires and diaries. The findings unveiled correlations between dietary patterns and glycemic control, with higher protein intake associated with improved glycated hemoglobin A1C values (p = 0.019), yet elevated fat and protein consumption was linked to heightened rates of hyperglycemia. Conversely, no significant relationship was observed between dietary variables and hypoglycemia occurrence. Interestingly, subjects with more readings of glucose levels consumed fewer carbohydrates (p = 0.004) and more proteins (p = 0.000). Furthermore, physical activity and marital status correlated with glycemic stability, while higher education was associated with enhanced glycemic control (p = 0.021). This study confirmed the importance of structured education on glycemic regulation and the importance of dietary patterns in glucose management. Also, the educational role of the FGM system in changing dietary habits was confirmed, which is one of the key factors for improving glycemic regulation in continuous glucose monitoring system users.
N6-Methyladenosine Modification-Related Genes Express Differentially in Sterile Male Cattle-Yaks
Authors: Liu Yuxin , Chen Lili , Jiang Hui , Wang Hongzhuang , Zhang Yujiao , Yuan Zhengrong , Ma Yi
Published: September 2024

N6-methyladenosine (m6A), an RNA post-transcriptional modification, plays a crucial role in spermatogenesis. Cattle-yaks are interspecific hybrid offsprings of yak and cattle, and male cattle-yaks are sterile. This study aims to investigate the role of m6A modification in male cattle-yak infertility. Herein, testicular tissues were analyzed via histological observations, immunohistochemical assays, reverse-transcription quantitative polymerase chain reaction, Western blotting, and immunofluorescence assays. The results revealed that male cattle-yaks presented smaller testes (5.933 ± 0.4885 cm vs. 7.150 ± 0.3937 cm), with only single cell layers in seminiferous tubules, and weakened signals of m6A regulators such as METTL14 (methyltransferase-like 14), ALKBH5 (alpha-ketoglutarate-dependent hydroxylase homolog 5), FTO (fat mass and obesity-associated protein), and YTHDF2 (YTH N6-methyladenosine RNA binding protein F2), both at the RNA and protein levels, compared with those of yaks. Altogether, these findings suggest that m6A modification may play a crucial role in male cattle-yak sterility, providing a basis for future studies.
Deciphering the Gut–Liver Axis: A Comprehensive Scientific Review of Non-Alcoholic Fatty Liver Disease
Authors: Singh Samradhi , Kriti Mona , Catanzaro Roberto , Marotta Francesco , Malvi Mustafa , Jain Ajay , Verma Vinod , Nagpal Ravinder , Tiwari Rajnarayan , Kumar Manoj
Published: September 2024

Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant global health issue. The condition is closely linked to metabolic dysfunctions such as obesity and type 2 diabetes. The gut–liver axis, a bidirectional communication pathway between the liver and the gut, plays a crucial role in the pathogenesis of NAFLD. This review delves into the mechanisms underlying the gut–liver axis, exploring the influence of gut microbiota, intestinal permeability, and inflammatory pathways. This review also explores the potential therapeutic strategies centered on modulating gut microbiota such as fecal microbiota transplantation; phage therapy; and the use of specific probiotics, prebiotics, and postbiotics in managing NAFLD. By understanding these interactions, we can better comprehend the development and advancement of NAFLD and identify potential therapeutic targets.
Multiscale Analysis of Sandwich Beams with Polyurethane Foam Core: A Comparative Study of Finite Element Methods and Radial Point Interpolation Method
Authors: Belinha Jorge
Published: September 2024

This study presents a comprehensive multiscale analysis of sandwich beams with a polyurethane foam (PUF) core, delivering a numerical comparison between finite element methods (FEMs) and a meshless method: the radial point interpolation method (RPIM). This work aims to combine RPIM with homogenisation techniques for multiscale analysis, being divided in two phases. In the first phase, bulk PUF material was modified by incorporating circular holes to create PUFs with varying volume fractions. Then, using a homogenisation technique coupled with FEM and four versions of RPIM, the homogenised mechanical properties of distinct PUF with different volume fractions were determined. It was observed that RPIM formulations, with higher-order integration schemes, are capable of approximating the solution and field smoothness of high-order FEM formulations. However, seeking a comparable field smoothness represents prohibitive computational costs for RPIM formulations. In a second phase, the obtained homogenised mechanical properties were applied to large-scale sandwich beam problems with homogeneous and approximately functionally graded cores, showing RPIM’s capability to closely approximate FEM results. The analysis of stress distributions along the thickness of the beam highlighted RPIM’s tendency to yield lower stress values near domain edges, albeit with convergence towards agreement among different formulations. It was found that RPIM formulations with lower nodal connectivity are very efficient, balancing computational cost and accuracy. Overall, this study shows RPIM’s viability as an alternative to FEM for addressing practical elasticity applications.
Effect of Alloying on Microstructure and Mechanical Properties of AlCoCrFeNi2.1 Eutectic High-Entropy Alloy
Authors: Tian Xue-Yao , Zhang Hong-Liang , Nong Zhi-Sheng , Cui Xue , Gu Ze-Hao , Liu Teng , Li Hong-Mei , Arzikulov Eshkuvat
Published: September 2024

In order to explore the effect of alloying on the microstructures and mechanical properties of AlCoCrFeNi2.1 eutectic high-entropy alloys (EHEAs), 0.1, 0.2, and 0.3 at.% V, Mo, and B were added to the AlCoCrFeNi2.1 alloy in this work. The effects of the elements and contents on the phase composition, microstructures, mechanical properties, and fracture mechanism were investigated. The results showed that the crystal structures of the AlCoCrFeNi2.1 EHEAs remained unchanged, and the alloys were still composed of FCC and BCC structures, whose content varied with the addition of alloying elements. After alloying, the aggregation of Co, Cr, Al, and Ni elements remained unchanged, and the V and Mo were distributed in both dendritic and interdendritic phases. The tensile strengths of the alloys all exceeded 1000 MPa when the V and Mo elements were added, and the Mo0.2 alloy had the highest tensile strength, of 1346.3 MPa, and fracture elongation, of 24.6%. The alloys with the addition of V and Mo elements showed a mixed ductile and brittle fracture, while the B-containing alloy presented a cleavage fracture. The fracture mechanism of Mo0.2 alloy is mainly crack propagation in the BCC lamellae, and the FCC dendritic lamellae exhibit the characteristics of plastic deformation.
Dynamic Response of Fiber–Metal Laminates Sandwich Beams under Uniform Blast Loading
Authors: Yang Jianan , Guo Yafei , Wu Yafei , Zhang Jianxun
Published: September 2024

In this work, theoretical and numerical studies of the dynamic response of a fiber–metal laminate (FML) sandwich beam under uniform blast loading are conducted. On the basis of a modified rigid-plastic material model, the analytical solutions for the maximum deflection and the structural response time of FML sandwich beams with metal foam core are obtained. Finite element analysis is carried out by using ABAQUS software, and the numerical simulations corroborate the analytical predictions effectively. The study further examines the impact of the metal volume fraction, the metal strength factor between the metal layer and the composite material layer, the foam strength factor of the metal foam core to the composite material layer, and the foam density factor on the structural response. Findings reveal that these parameters influence the dynamic response of fiber–metal laminate (FML) sandwich beams to varying degrees. The developed analytical model demonstrates its capability to accurately forecast the dynamic behavior of fiber–metal laminate (FML) sandwich beams under uniform blast loading. The theoretical model in this article is a simplified model and cannot consider details such as damage, debonding, and the influence of layer angles in experiments. It is necessary to establish a refined theoretical model that can consider the microstructure and failure of composite materials in the future.
Physicochemical Characterization of Ca- and Cu-Decorated TiO2 Microparticles and Investigation of Their Antimicrobial Properties
Authors: Neacsu Andreea , Chihaia Viorel , Bucuresteanu Razvan , Ficai Anton , Trusca Roxana Doina , Surdu Vasile-Adrian , Nicolaev Adela , Cojocaru Bogdan , Ionita Monica , Calinescu Ioan , Parvulescu Viorica , Ditu Lia-Mara
Published: September 2024

Ca- and Cu-decorated TiO2 microparticles are titanium dioxide nanoparticles that have been decorated with calcium and copper ions. TiO2, CaO, and CuO are low-cost, non-toxic, and non-hazardous materials. The aim of the present study was the physicochemical characterization of Ca- and Cu-decorated TiO2 microparticles and the evaluation of their antimicrobial activity. Thus, Ca2+ and Cu2+ species were incorporated onto TiO2 surfaces by a two-step wet method. The obtained TiO2-CaO-CuO composites were characterized by several experimental techniques. The electronic structure and charge properties of the composites were investigated by density functional theory calculations. Furthermore, the composites were successfully tested for inhibitory effects on Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans standard strains. The zeta potential data indicate that the physiological condition of investigated microbial strains was strongly affected in presence of a dispersion of 10 μg/L of composites in a saline phosphate buffer also, the recorded SEM images show a damaged microbial cell surface in the presence of composites.
Sojourn Time Analysis of a Single-Server Queue with Single- and Batch-Service Customers
Authors: Koyama Yusei , Nakamura Ayane , Phung-Duc Tuan
Published: September 2024

There are various types of sharing economy services, such as ride-sharing and shared-taxi rides. Motivated by these services, we consider a single-server queue in which customers probabilistically select the type of service, that is, the single service or batch service, or other services (e.g., train). In the proposed model, which is denoted by the M+M(K)/M/1 queue, we assume that the arrival process of all the customers follows a Poisson distribution, the batch size is constant, and the common service time (for the single- and batch-service customers) follows an exponential distribution. In this model, the derivation of the sojourn time distribution is challenging because the sojourn time of a batch-service customer is not determined upon arrival but depends on single customers who arrive later. This results in a two-dimensional recursion, which is not generally solvable, but we made it possible by utilizing a special structure of our model. We present an analysis using a quasi-birth-and-death process, deriving the exact and approximated sojourn time distributions (for the single-service customers, batch-service customers, and all the customers). Through numerical experiments, we demonstrate that the approximated sojourn time distribution is sufficiently accurate compared to the exact sojourn time distributions. We also present a reasonable approximation for the distribution of the total number of customers in the system, which would be challenging with a direct-conventional method. Furthermore, we presented an accurate approximation method for a more general model where the service time of single-service customers and that of batch-service customers follow two distinct distributions, based on our original model.
Research on Service Quality for China’s Ceramic Product Design Industry
Authors: Zhu Junxi , Lin Chia-Liang
Published: September 2024

As a part of the service industry, product design practitioners should possess an understanding of the multifaceted factors and solutions that contribute to delivering exceptional service quality. However, related research on the service quality factors and solutions for China’s ceramic product design industry is still an important research gap. In view of this, an integrated approach based on multi-criteria decision making (MCDM), combining the fuzzy analytic hierarchy process (FAHP) and the measurement of alternatives and ranking according to compromise solution (MARCOS), was proposed in this research to analyse and evaluate the service quality factors and solutions for China’s ceramic product design industry. Initially, the FAHP method determined the significance of the service quality dimensions and indicators. Subsequently, the MARCOS method ranked the alternatives based on their performance against these criteria. This research focuses on the growing subject of service quality in China’s ceramic product design industry. The proposed model identifies essential service quality factors and solutions for China’s ceramic product design industry. The findings of this study may assist ceramic product design practitioners in China in making strategic decisions to provide excellent service quality.
Association between Premature Birth and Air Pollutants Using Fuzzy and Adaptive Neuro-Fuzzy Inference System (ANFIS) Techniques
Authors: Castellões Taynara de Oliveira , Rizol Paloma Maria Silva Rocha , Nascimento Luiz Fernando Costa
Published: September 2024

This article uses machine learning techniques as fuzzy and neuro-fuzzy ANFISs, to develop and compare prediction models capable of relating pregnant women’s exposure to air pollutants, such as Nitrogen Dioxide and Particulate Matter, the mother’s age, and the number of prenatal consultations to the incidence of premature birth. In the current literature, studies can be found that relate prematurity to the exposure of pregnant women to NO2, O3, and PM10; to Toluene and benzene, mainly in the window 5 to 10 days before birth; and to PM10 in the week before birth. Both models used logistic regression to quantify the effects of pollutants as a result of premature birth. Datasets from Brazil—Departamento de Informatica do Sistema Único de Saúde (DATASUS) and Companhia Ambiental do Estado de São Paulo (CETESB)—were used, covering the period from 2016 to 2018 and comprising women living in the city of São José dos Campos (SP), Brazil. In order to evaluate and compare the different techniques used, evaluation metrics were calculated, such as correlation (r), coefficient of determination (R2), Root Mean Square Error (RMSE), Mean Absolute Percentage Error (MAPE), Mean Square Error (MSE), and Mean Absolute Error (MAE). These metrics are widely used in the literature due to their ability to evaluate the robustness and efficiency of prediction models. For the RMSE, MAPE, MSE, and MAE metrics, lower values indicate that prediction errors are smaller, demonstrating better model accuracy and confidence. In the case of (r) and R2, a positive and strong result indicates alignment and better performance between the real and predicted data. The neuro-fuzzy ANFIS model showed superior performance, with a correlation (r) of 0.59, R2 = 0.35, RMSE = 2.83, MAPE = 5.35%, MSE = 8.00, and MAE = 1.70, while the fuzzy model returned results of r = 0.20, R2 = 0.04, RMSE = 3.29, MSE = 10.81, MAPE = 6.67%, and MAE = 2.01. Therefore, the results from the ANFIS neuro-fuzzy system indicate greater prediction capacity and precision in relation to the fuzzy system. This superiority can be explained by integration with neural networks, allowing data learning and, consequently, more efficient modeling. In addition, the findings obtained in this study have potential for the formulation of public health policies aimed at reducing the number of premature births and promoting improvements in maternal and neonatal health.
Health Impacts of Pre-eclampsia: A Comprehensive Analysis of Maternal and Neonatal Outcomes
Authors: Socol Flavius George , Bernad Elena , Craina Marius , Abu-Awwad Simona-Alina , Bernad Brenda-Cristiana , Socol Ioana Denisa , Abu-Awwad Ahmed , Farcas Simona Sorina , Pop Daniel Laurențiu , Gurgus Daniela , Andreescu Nicoleta Ioana
Published: September 2024

Background and Objectives: Hypertensive disorders, particularly pre-eclampsia, pose significant risks during pregnancy, affecting both maternal and neonatal health. The study aims to analyze short- and long-term health implications for mothers and their children, comparing those with pre-eclampsia to those without, to improve understanding of risk factors, diagnostic markers, and outcomes. Materials and Methods: This retrospective observational study involved 235 patients, 98 with pre-eclampsia and 137 without, monitored from 2015 to 2018 at the Obstetrics and Gynecology Department of the “Pius Brînzeu” Emergency County Clinical Hospital in Timișoara, Romania. Results: Women with pre-eclampsia were older, had higher BMIs, and more frequently had a family history of pre-eclampsia, hypertension, and diabetes. They also had lower educational and socioeconomic levels and fewer prenatal visits. Biochemical markers such as higher proteinuria, elevated sFlt-1, and lower PlGF were significant in diagnosing pre-eclampsia. Short-term maternal complications like eclampsia, HELLP syndrome, and acute kidney injury were more prevalent in the pre-eclampsia group. Neonatal outcomes included higher rates of preterm birth, low birth weight, and NICU admissions. Long-term mothers with a history of pre-eclampsia had higher incidences of chronic hypertension, cardiovascular disease, kidney problems, diabetes, and mental health disorders. Their children faced increased risks of neuropsychological delays, chronic respiratory issues, behavioral disorders, learning difficulties, and frequent infections. Conclusions: The study highlights the significant short- and long-term health impacts of pre-eclampsia on both mothers and their children. Early monitoring, intervention, and comprehensive management are crucial in mitigating these risks. These findings underscore the need for personalized care strategies to improve health outcomes for affected individuals.
Transcranial Corticospinal Motor-Evoked Potentials in Cases of Ventral and Ventrolateral Intradural Extramedullary Cervical Spinal Cord Tumors
Authors: Vasileva Petra , Hristov Hristo , Bussarsky Assen , Tanova Rositsa , Karakostov Vasil , Ferdinandov Dilyan
Published: September 2024

Background and Objectives: We studied the clinical significance of an amplitude decrement and disappearance alarm criteria in transcranial motor-evoked potential (MEP) monitoring during surgeries on extramedullary tumors at the cervical spine with reference to postoperative morbidity. Material and Methods: We diagnosed and surgically treated fourteen patients with intradural extramedullary ventral or ventrolateral lesions to the cervical spinal cord in the Clinic of Neurosurgery at the University Hospital St Ivan Rilski from January 2018 to July 2022. Eight cases were diagnosed with schwannoma, and the remaining six had meningiomas. The follow-up period for neurological assessment was six months. Results: A decrease in the intraoperative transcranial MEPs of 50% or more compared to baseline in two cases (14.3%) resulted in an immediate postoperative motor deficit. One patient demonstrated full neurological recovery within six months, while the other exhibited only partial improvement. In six cases (42.9%) with preoperative motor deficits, tumor resection and decompression of the cervical spinal cord led directly to an increment of the transcranial MEPs by more than 20%. Postoperatively and at the 6-month follow-up, these patients showed recovery from the preoperative deficits. In the remaining cases, MEPs were stable during surgery with no clinical deterioration of the motor function. Conclusions: The decremented MEP criteria corresponded to postoperative motor deficit, whereas the improvement of the same parameters after decompression implied future recovery of preoperative motor deficits. The combination of different MEP criteria is likely to be helpful when tailored to a specific case of ventral or ventrolateral extramedullary lesions in the cervical spine.
Efficient Second-Harmonic Generation in Adapted-Width Waveguides Based on Periodically Poled Thin-Film Lithium Niobate
Authors: He Junjie , Liu Lian , Lin Mianjie , Chen Houhong , Ma Fei
Published: September 2024

Frequency conversion process based on periodically poled thin-film lithium niobate (PPTFLN) has been widely recognized as an important component for quantum information and photonic signal processing. Benefiting from the tight confinement of optical modes, the normalized conversion efficiency (NCE) of nanophotonic waveguides is improved by orders of magnitude compared to their bulk counterparts. However, the power conversion efficiency of these devices is limited by inherent nanoscale inhomogeneity of thin-film lithium niobate (TFLN), leading to undesirable phase errors. In this paper, we theoretically present a novel approach to solve this problem. Based on dispersion engineering, we aim at adjusting the waveguide structure, making local waveguide width adjustment at positions of different thicknesses, thus eliminating the phase errors. The adapted waveguide width design is applied for etched and loaded waveguides based on PPTFLN, achieving the ultrahigh power conversion efficiency of second harmonic generation (SHG) up to 2.1 × 104%W−1 and 6936%W−1, respectively, which surpasses the power conversion efficiency of other related works. Our approach just needs standard periodic poling with a single period, significantly reducing the complexity of electrode fabrication and the difficulty of poling, and allows for the placing of multiple waveguides, without individual poling designs for each waveguide. With the advantages of simplicity, high production, and meeting current micro–nano fabrication technology, our work may open a new way for achieving highly efficient second-order nonlinear optical processes based on PPTFLN.