bluuebunny/crossref_metadata_2025 huggingface dataset:
Introduced resistant grape variety Frontenac Blanc
Authors: Krasokhina S. I. , Matveeva N. V.
Published: October 2023

Th e paper presents a variety trial and technological evaluation of the wine material from Frontenac Blanc grape, isolated as a color mutation in Canada plantations of the Frontenac Gris variety in 2006. Th e study was carried out in 2020–2022 in compliance with vitiviniculture recognized methodology in soil and climatic conditions of Potapenko All-Russian Research Institute of Viticulture and Winemaking, a branch of Federal Rostov Agrarian Scientifi c Centre, Novocherkassk, Rostov Oblast, Russia. Vineyards are open-earth, rainfed, graft ed, with Kober 5BB rootstock, 3.0×1.5 m planting scheme, shaping: double-shouldered low (40 cm) horizontal cordon, short pruning on knots. Agricultural technology is standard, generally recognized. Frontenac Blanc is found to obtain high winter hardiness, promising for open-earth cultivation. Th e variety has good resistance to infections: to mildew (2.0 score), oidium (2.5 score); grey rot has not been observed. Th erefore, frequent use of pesticides is not required and vineyard maintenance is simplifi ed. Th e high level of sugars (248 g/dm3) and t itratable acids (10.4 g/dm3) in t h e juice ensures a harmonious wine with well-balanced acidity. Due to such characteristics, the variety is considered to be promising for the production of diff erent wine styles, including dry still, semi-dry, as well as sparkling and liqueur wines. Th e wine material from Frontenac Blanc presents a distinguishing character, bright fruit aromas, rich structured fl avor, and lingering fi nish. Th e average tasting score of the wine material comprises 8.6 points (on a 1–10 scale). Th e variety has a high yield (16 tonnes/ha), which does not adversely aff ect the quality of products. Frontenac Blanc is resistant to cold and early ripening period (120 days) and can be eff ectively grown in regions with previously limited production due to extreme climatic conditions. Considering that, an innovative development of the wine industry in areas with cool and uncertain climate possesses a high potential.
Nomenclature standards of honeysuckle varieties selected by the Pavlovsk Experimental Station of the Vavilov All-Russian Institute of Plant Genetic Resources
Authors: Bagmet L. V. , Tikhonova N. G.
Published: October 2023

Nomenclature standards of 17 varieties of honeysuckle selected by the Pavlovsk Experimental Station of N. I. Vavilov All-Russian Institute of Plant Genetic Resources (VIR) were developed under the Project on creation nomenclature standards for varieties of cultivated plants of domestic selection in the VIR. Plant material for herbarium specimens designated as nomenclature standards was gathered at the flowering and fruiting stages (2020, 2021) in the collection of the originator (Pushkinsk and Pavlovsk laboratories of VIR) in assistance of a cobreeder of these varieties. The herbarization process involves selecting variety-specific parts of the plant (flowers, vegetative and generative shoots, berries). A herbarium label specifies a herbarium code of the specimen in the VIR herbarium, a Latin name of the species, a name of the variety, an origin (name of the organization where the variety was created), a place of generation (where the herbarium plant was grown), dates of collection, names of collectors. Each herbarium specimen is supplemented with photographs of flowers and berries. The nomenclature standards were drawn in accordance with the recommendations of The International Code of Nomenclature for Cultivated Plants (ICNCP) as well as the VIR-developed protocol, and were registered in the VIR herbarium database. As a result of the study, nomenclature standards of the following honeysuckle varieties were created, formalized and deposited in the Herbarium of Cultivated plants of the world, their wild relatives and weeds (WIR): Altair (WIR-97772), Amphora (WIR-97778), Bogdana (WIR-97780), Viola (WIR-97784), Volkhova (WIR-97785), Lebedushka (WIR97834), Malvina (WIR-97837), Morena (WIR-97838), Nympha (WIR-97839), Omega (WIR-97840), Pavlovskaya (WIR-97841), Pushkinskaya (WIR-97842), Slavyanka (WIR-97845), Sodruzhestvo (WIR-97847), Solovey (WIR97848), Souvenir (WIR-97975), Fialka (WIR-97978).
PENERAPAN AUGMENTED REALITY BERBASIS ANDROID SEBAGAI MEDIA PEMBELAJARAN PENDIDIKAN BUDAYA MELAYU RIAU ROKAN HULU
Authors: Rangga Bakti Imam , Supriyanto Asep , Riki Mustafa Satria
Published: October 2023

Penggunaan teknologi, informasi dan komunikasi pada saat ini adalah sebuah ciri yang mana kehidupan manusia saat ini telah memasuki abas ke-21. Dalam proses belajar mengajar atau pembelajaran saat ini tidak jauh dari pemanfaatan TIK dalam prosesnya diantaranya adalah penggunaan Augmented Reality. Pada Penelitian ini bertujuan mengkaji urgensi pemanfaatan Augmented Reality dalam pembelajaran untuk melestarikan kebudayaan khususnya Budaya Melayu Riau Rokan Hulu. Dalam prosesnya kajian ini melalui tinjauan literatur yang berfokus pada Augmented Reality untuk pembelajaran yang mana memanfaatkan teknologi mobile android serta pemanfaatannya dalam pelestarian budaya Melayu Riau Rokan Hulu. Penelitian ini menggunakan Metode Multimedia Development Life Cycle, merupakan metode pengembangan multimedia terdiri dari enam tahap, yaitu Concept, Design, Material Collecting, Assembly, Testing, dan Distribution. rujukan pengembangan media pembelajaran pada aspek pelestarian kebudayaan pada mata pelajaran Budaya Melayu Riau. Banyak ditemukan pelestarian kebudayaan berbasis AR di lingkungan belajar formal dan informal (yaitu sekolah, museum, taman, kebun binatang, objek wisata, dan cagar budaya). Integrasi AR pada model pembelajaran, bahan ajar, dan perangkat pembelajaran lainnya semakin diharapkan untuk menciptakan proses pembelajaran yang inovatif dan variatif. Integrasi ini akan memberikan dorongan dan capaian kemampuan siswa yang lebih efektif dan efisien.
Research on Condition Monitoring of Transformer Respirator Based on Temperature and Humidity Sensing and Visual Judgment
Authors: Wei Xinxin
Published: October 2023

This paper expounds on the significance of building an intelligent operation and inspection system for substation operation and maintenance and carrying out digital transformation. The function, structure and principle of transformer breather are introduced. The practical problems faced by transformer respirators during operation and inspection are pointed out. Based on the above problems, a transformer respirator status monitoring system based on temperature and humidity sensing and visual judgment linkage is proposed, including temperature and humidity sensing terminal, video linkage module, data processing terminal and wireless communication terminal. A respirator status monitoring platform is set up. It is known from the test data that a temperature and humidity sensor should be selected and placed in the middle of 2/3 of the height of the respirator. The platform can monitor the status of respirators online in real time, reduce the number of inspections by operation and maintenance personnel, reduce work intensity, and improve work efficiency.
Effect of Curing Agent Type on Curing Reaction Kinetics of Epoxy Resin
Authors: Wang Chuan , Xin Xue , Zhang Ning , Jiao Yuepeng , Chi Zhaoming , Wang Yong , Liang Ming
Published: October 2023

Curing agent types have a great influence on the reaction kinetics and post-curing properties of epoxy resins. The dynamic process of epoxy resin curing reaction will affect the structure, morphology and mechanical properties of cured products. In this paper, low molecular weight polyamides, aromatic amines and anhydrides were selected as three kinds of curing agents and their isothermal viscosity-time properties were studied to investigate the operational time and curing speed of the resin system. The non-isothermal Differential Scanning Calorimetry (DSC) method was conducted to study the curing reaction kinetics of three kinds of curing agent/epoxy resin systems so as to deduce the curing reaction kinetics model and calculate the corresponding kinetic parameters. Results showed that a low molecular weight polyamide curing agent blend resin system can occur at a lower temperature of curing reaction and the cure rate is fast. The curing process of the aromatic amine curing agent blend resin system is divided into two steps, while the anhydride curing agent blend system should be able to cure at high temperatures and have a long operating time. The theoretical curing temperatures of the three curing agents of low molecular polyamide, aromatic amine, primary curing and secondary curing and acid anhydride are respectively 74.13°C, 86.31°C, 165.24°C and 152.90°C, which are also the recommended curing temperatures of the corresponding curing agents.
Neutronic Chain Reactions for Polonium-210 Production
Authors: Lim Solomon
Published: October 2023

The production of the industrially significant radionuclide polonium-210 from the neutron irradiation of bismuth metal and the subsequent beta decay of bismuth-210 is highly inefficient due to the small neutron capture cross section of bismuth-209. In this paper, we report a previously undescribed self-sustaining nuclear chain reaction involving self-propagating neutron multiplication in bismuth salts that allow for rapid and cost-effective production of polonium-210. The reaction proceeds in a cycle of three alternating elementary steps – the capture of neutrons by bismuth-209 and the subsequent formation of polonium-210, the emission of high-energy alpha particles by polonium-210, and the production of more neutrons from (α, n) and (n,2n) reactions on light element and bismuth-209 nuclei respectively. Furthermore, the high hydrogen density of the compound also confers it intrinsic neutron moderation properties, increasing the neutron capture cross section of bismuth-209 at thermal neutron energies. The chain reaction was proven to have successfully occurred by irradiating a sample of the bismuth salt with a 80 μCi neutron source and monitoring the activity levels of the reaction. It was found that the activity of the reaction increased exponentially after an initial stable period following a derived formula for polonium production trends for the reaction, thus validating the occurrence of the reaction. Furthermore, alpha spectroscopy confirmed that polonium-210 had been produced by characterising the 5.30 MeV alpha emission peak of the reaction in addition to using beta spectroscopy to identify the parent nuclide bismuth-210, further proving that the reaction was successful. Hence, this paper reports the successful initiation and characterisation of a novel nuclear chain reaction, and its potential applications offered by a method of rapidly producing large quantities of polonium-210.
Debt Moratorium: Theory and Evidence
Authors: Kürsat Önder Yasin , Villamizar-Villegas Mauricio , Villegas Jose
Published: October 2023

Our study analyzes the impact of debt moratorium policies, possibly the oldest approach to addressing repayment problems. Using Colombian administrative data, we compare firms that narrowly met the criteria for moratoria (eligible firms could not exceed 60 days overdue on their loans) with those that just missed it. Our findings reveal that stressed firms accessing moratoria experience more favorable loan conditions on subsequent borrowing, characterized by higher loan amounts and lower interest rates. This credit relief, in turn, contribute to substantial increases in firm investment and employment. To delve deeper into the implications, we employ a quantitative general equilibrium model of default to assess both short- and long-term effects. While these policies effectively mitigate liquidity concerns, they concurrently elevate default risks. Notably, our research underscores larger welfare gains when debt moratorium policies incorporate interest forgiveness during periods of debt standstill by reducing default risk.
ВПЛИВ ІТ-ТЕХНОЛОГІЙ НА МІЖНАРОДНУ БІЗНЕС-ДІЯЛЬНІСТЬ: СУТНІСТЬ ТА ФОРМИ ПРОЯВУ
Authors: Максименко Анна , Галенко Петро
Published: October 2023

У статті уточнюється позиціонування ІТ-технологій у міжнародному бізнесі, що спрощують і прискорюють процеси, які відбуваються щодня і щохвилини. Проаналізовано та систематизовано процеси та етапи, на яких технології відіграють важливу роль. Вивчено міжнародний досвід створення та розвитку ІТ-технологій та їх використання в абсолютній більшості сфер і підрозділів. Уточнено як технології революціонізували життя як споживачів, так і компаній. У статті досліджується різноманітность продуктів і послуг, які завдяки технологіям полегшують доступ до інформації, що сприяє поліпшенню та оптимізації багатьох бізнес-професів. Доведено, що сфера міжнародного бізнесу особливо чутлива до технологічних інновацій. На ринковому рівні цифровізація впливає на конкуренцію, сприяючи «розмиванню ринкових кордонів», появі нових галузей і появі бізнес-екосистем.
МІГРАЦІЯ РОБОЧОЇ СИЛИ В УКРАЇНІ: ВИКЛИКИ ДЛЯ УПРАВЛІННЯ ТА МОТИВАЦІЇ ПЕРСОНАЛУ ПІД ЧАС ВІЙНИ
Authors: Цимбалюк Ірина , Хомюк Наталія , Зелінська Олена
Published: October 2023

У статті розкрито масштаби та складність проблеми масової міграції як національного, так і глобального значення. Проаналізовано дані Верховного комісаріату ООН у справах біженців, які підтверджують, що війна в Україні призвела до найбільшої кризи в історії глобального вимушеного переміщення населення. Проаналізовано наслідки відтоку робочої сили з України, що призводить до дефіциту кваліфікованих працівників та має негативний вплив на економіку й соціальну сферу країни-джерела міграції. Розкрито позитивний вплив масштабної міграції з України до країн Європейського Союзу, зокрема на економіку та демографічну ситуацію приймаючих країн. Запропоновано підхід до розв’язання проблеми масової міграції кваліфікованої робочої сили шляхом адаптації мотиваційної політики підприємства відповідно до нагальних потреб працівників в умовах воєнного стану. Систематизовано основні принципи управління мотивацією персоналу у воєнний час які дають змогу ефективно управляти та підтримувати високий рівень мотивації персоналу навіть у найскладніших обставинах. Підкреслюється важливість збереження персоналу, який є ключовим активом підприємства в умовах війни, через ефективні мотиваційні механізми, що відповідають сучасним викликам та реаліям.
Inspecting sector-specific capital structure determinants: The case of Malaysian Shariah firms
Authors: Rehan Raja , Sa’ad Auwal Adam , Haron Razali , Hye Qazi Muhammad Adnan
Published: October 2023

This study is set to inspect sector-specific capital structure determinants for publicly listed Malaysian Shariah-tagged firms. For this purpose, a 17-year data sample set comprising 343 Shariah firms in Bursa Malaysia’s main market is constructed. The seven key determinants, namely fixed assets, non-debt tax shield, current assets, growth, return on equity, size, and earnings per share, are measured as capital structure determinants in relation to the debt-equity ratio. Deploying a Dynamic Panel Data Model via an efficient econometric assessor, i.e., Generalized Method of Moments, the investigation exposes that current and fixed assets are observed as the key significant sector-specific capital structure determinants for Malaysian Shariah-tagged firms. Also, the positive and significant lagged dependent variables of each studied sector indicate the presence of a targeted capital structure and Speed of Adjustment (SOA). The occurrence of SOA explains variations in the debt-equity choices of Malaysian Shariah firms at the sector level. The significant tangibility and liquidity in most sectors and the significant lagged dependent variables across all sectors directly suggest the significance of the dynamic theory of Trade-Off. As a whole, it is observed that the sector-level capital structure framing practices of Shariah-tagged firms are not similar. This study aims to investigate the optimal debt-equity mix for listed Malaysian Shariah-complaint enterprises operating in diverse sectors. The observed outcomes are the baseline for policymakers to formulate a better financing model that supports Malaysian Shariah firms to maintain a dynamic or targeted capital structure at all times.
A különleges bánásmódot igénylő tanulókkal való foglalkozás összefüggései a szakmai
tanárképzés szempontjából
Authors: Benedek András
Published: October 2023

2022 közepére körvonalazódott, hogy a Magyar Pedagógiai Társaság (MPT) Szakképzési
Kollégiuma (SZK) közreműködik az „Esélyek és kihívások – SNI és BTMN tanulók a
szakképzésben” konferencia előkészítésében. Az ELTE Bárczi Gusztáv Gyógypedagógiai Kar
és a Budapesti Gépészeti Centrum Öveges József Technikum és Szakképző Iskola által
szervezett 2023. április 21-i rendezvény célja a szakképzésben részt vevő atipikus
fejlődésű – sajátos nevelési igényű és beilleszkedési, tanulási, magatartási
nehézségekkel élő (BTMN) – tanulók sikeres szakma szerzésének és munkaerő-piaci
megfelelésének, esélyeinek elősegítése volt. A konferencia lehetőséget kívánt adni arra,
hogy az irányító szervek képviselői, a területen dolgozó szakemberek (a szakképzési
intézmények és a duális képzőhelyek oktatói, gyógypedagógusok, fejlesztő pedagógusok,
illetve az érintettek (tanulók és szüleik) megosszák egymással a témában releváns
információkat, tapasztalataikat és jó gyakorlataikat, kiépüljenek kölcsönösen előnyös
kapcsolatok, valamint javaslatok, ajánlások fogalmazódjanak meg. A szervezők az alapos
előkészítő munka keretében előzetes felmérésre is vállalkoztak, mely alapján a
legnagyobb arányban az alábbi két téma feldolgozása iránt mutatkozott igény: (1) Az
intézmények és a duális partnerek oktatóinak felkészülése az SNI, BTMN tanulókkal való
eredményes foglalkozásra. (2) Együttműködés az oktatók és a célcsoport speciális
támogatását végző gyógypedagógusok, fejlesztő pedagógusok között.
Módszertani megoldások az SNI és BTMN tanulók iskolarendszerű szakképzésében
Authors: Turcsik Katalin , Dunás-Varga Ildikó
Published: October 2023

Az írás az Esélyek és kihívások – SNI és BTMN tanulók a szakképzésben című, 2023.
április 21-én megvalósult konferencia szekcióülésein felvetett témaköröket foglalja
össze, amelyek a szakképzési intézmények tantermeiben és tanműhelyeiben, a duális
képzés, valamint az értékelés és vizsgáztatás során megvalósítható módszertani
megoldások voltak. A szekciómegbeszéléseken elhangzottak összefoglalásán túl a szerzők
továbbgondolják és kiegészítik a résztvevők által megfogalmazott gondolatokat és
tapasztalatokat.
Susceptibility of pediatric acute lymphoblastic leukemia to STAT3 inhibition depends on p53 induction
Authors: Gasparoli Luca , Virely Clemence , Tsakaneli Alexia , Che Noelia , Edwards Darren , Bartram Jack , Hubank Michael , Pal Deepali , Heidenreich Olaf , Martens Joost H.A. , De Boer Jasper , Williams Owen
Published: October 2023

Advances in the clinical management of pediatric B cell Acute Lymphoblastic Leukemia (B-ALL) have dramatically improved outcomes for this disease. However, relapsed and high-risk disease still contribute to significant numbers of treatment failures. Development of new, broad range therapies is urgently needed for these cases. We previously reported the susceptibility of ETV6-RUNX1+ pediatric B-ALL to inhibition of signal transducer and activator of transcription 3 (STAT3) activity. In the present study, we demonstrate that pharmacological or genetic inhibition of STAT3 results in p53 induction and that CRISPR-mediated TP53 knockout substantially reverses susceptibility to STAT3 inhibition. Furthermore, we demonstrate that sensitivity to STAT3 inhibition in patient-derived xenograft (PDX) B-ALL samples is not restricted to any particular disease subtype, but rather depends on TP53 status, the only resistant samples being TP53 mutant. Induction of p53 following STAT3 inhibition is not directly dependent on MDM2 but correlates with degradation of MDM4. As such, STAT3 inhibition exhibits synergistic in vitro and in vivo anti-leukemia activity when combined with MDM2 inhibition. Taken together with the relatively low frequency of TP53 mutations in this disease, these data support the future development of combined STAT3/MDM2 inhibition in the therapy of refractory and relapsed pediatric B-ALL.
FORECASTING UNEMPLOYMENT IN INDONESIAUSING WEIGHTED MOVING AVERAGE METHOD
Authors: Syafwan Havid , Putri Pristiyanilicia , Syafwan Mahdhivan
Published: October 2023

Abstract: Unemployment is a global economic issue that directly impacts human life in both developed and developing countries, especially in Indonesia, which, if ignored, will severely impact society's social dynamics. To overcome this problem, forecasts are made so that later, the government can take policies to control and suppress the unemployment growth rate. This research aims to predict unemployment in Indonesia in 2023 using the Weighted Moving Average method, widely used to determine the trend of a time series, which is part of one of the Time Series methods that gives different weights. The dataset used was obtained from the Central Statistics Agency (BPS) relating to unemployment data from 2000 to 2022 (23 years). To analyze the level of accuracy of the results of this unemployment forecast using the MAD, MSE, and MAPE methods. This research concludes that the Weighted Moving Average method can be applied in predicting unemployment in Indonesia in 2023. The results of this research are a prediction of the number of unemployed in Indonesia, as many as 8,874,942 people at a weight value of 3 (three) where the accuracy of the MAD value is 745786.1833, the MSE value is 948402050986.3 and MAPE is 8.28%. Keywords: forecasting; unemployment; weigth moving average; indonesia Abstrak: Pengangguran menjadi isu ekonomi global yang berdampak secara langsung terhadap tingkat kehidupan manusia di negara-negara yang sudah maju maupun yang sedang berkembang khususnya di negara Indonesia, yang jika diabaikan akan berdampak serius terhadap dinamika sosial masyarakat. Untuk mengatasi permasalahan tersebut dibuatlah peramalan agar nantinya pemerinta dapat mengambil kebijakan dalam mengendalikan dan menekan angka pertumbuhan pengangguran tersebut. Penelitian ini bertujuan untuk memprediksi pengangguran di Indonesia pada tahun 2023 menggunakan metode Weighted Moving Average dimana metode ini banyak digunakan untuk menentukan trend dari suatu deret waktu yang merupakan bagian dari salah satu metode Time Series yang memberikan bobot yang berbeda-beda. Adapun dataset yang digunakan diperoleh dari Badan Pusat Satatistik (BPS) berkaitan dengan data pengangguran dari tahun 2000 sampai dengan tahun 2022 (selama 23 tahun).  Untuk menganalisa tingkat akurasi dari hasil peramalan pengangguran ini memakai metode MAD, MSE, dan MAPE. Kesimpulan dari penelitian ini yaitu dapat diterapkannya metode Weighted Moving Average dalam memprediksi pengangguran di Indonesia pada tahun 2023. hasil dari penelitian ini berupa prediksi jumlah pengangguran di Indonesia sebanyak 8.874.942 orang  pada nilai bobot 3 (tiga) dimana akurasi nilai MAD sebesar 745786,1833, nilai MSE sebesar 948402050986,3 dan MAPE sebesar 8,28 %. Kata kunci: peramalan; pengangguran; weigth moving average; indonesia
Perancangan Template Promosi di Instagram dengan Menggunakan Aplikasi Powerpoint Untuk Untuk Pemasaran Pengusaha Kuliner di Kota Malang
Authors: Bakti Amar Ma’ruf Stya , Rahmadianto Sultan Arif
Published: October 2023

Era digital saat ini dimanfaatkan oleh para pelaku usaha kuliner dalam memasarkan produk-produknya. Mulai dari pengembangan branding, media promosi di media sosial, menyewa jasa duta merk (brand ambassador) dan lain sebagainya. Dari beberapa alternatif untuk memasarkan produk para pelaku usaha kuliner terdapat salah satu media promosi yang mudah dan sederhana dengan memanfaatkan tampilan instagram feed yang didesain menggunakan aplikasi powerpoint. Alasan pemilihan software ini yaitu mudah didapatkan, digunakan dan dioperasikan serta mayoritas orang mempunyai aplikasi tersebut baik diperangkat laptop maupun komputer desktop (PC). Metode yang dipakai yaitu metode pengembangan model ADDIE  yang terdiri dari: Analysis, Design, Development, Implementation, and Evaluation. Hasil yang didapatkan berupa template desain media promosi sebanyak 40 desain template yang digunakan oleh para UMKM kuliner untuk menjual produknya melalui platform instagram.
Comparison of five commercial kits for isolation of total RNA in samples of WSSV-infected shrimp
Authors: Encinas-García T , Mendoza-Cano F , Muhlia-Almazán A , Vega-Peralta J , Sánchez-Paz A
Published: October 2023

Viral diseases are the most serious threat to the expansion and development of shrimp aquaculture. Rapid diagnosis of the white spot syndrome virus (WSSV), a lethal shrimp pathogen, is essential to restrict its spread and reduce the mortality of infected shrimp. This virus has globally affected the shrimp farming industry, with a devastating economic impact. Several studies have focused on the expression of WSSV transcripts to understand the molecular mechanisms governing the pathological development of the disease. Since gene expression studies and molecular diagnostics at the early stages of infection depend on the efficient isolation of high-quality RNA, the extraction methods should be carefully selected. However, previous comparisons of the performance of RNA isolation kits have yet to be systematically investigated. In this study, 5 commercial RNA extraction methods were compared in WSSV-infected shrimp. The highest total RNA yield (ng mg-1tissue) was obtained using TRIzol. Even though the 260/280 nm absorption ratios showed significant differences, the methods showed good purity values (>2.0). RNA integrity was evaluated in a denaturing agarose gel electrophoresis, and degradation was observed after the total RNA samples were treated with DNase I. Finally, the method that allowed the earlier detection of WSSV transcripts by qRT-PCR was the Zymo Direct-zol RNA MiniPrep kit. This study shows that the amount of observed (or estimated) WSSV transcripts might be affected because of the RNA isolation method. In addition, these results may contribute to improve the accuracy of the results obtained in gene expression studies, for more sensitive and robust detection of WSSV.
Seasonal variation in diet and isotopic niche of nominally herbivorous fishes in subtropical rocky reefs
Authors: Cardozo-Ferreira GC , Ferreira CEL , Choat JH , Mendes TC , Macieira RM , Rezende CE , Joyeux JC , Clements KD
Published: October 2023

Herbivorous fishes can be sensitive to environmental fluctuations, which influence both availability of food resources and metabolic rate, and thus nutritional requirements. Impacts on herbivore nutritional ecology may result from seasonal variations in temperature and meteoceanographic shifts such as wind-induced upwelling events. We evaluated the effects of seasonal changes on the nutritional ecology of 3 nominally herbivorous fishes (Acanthurus chirurgus, Sparisoma axillare and Kyphosus vaigiensis) in a subtropical rocky reef on the southeastern Brazilian coast using a combination of gut content analysis (at 2 scales of magnification) and stable isotope analysis. Sampling of in situ water temperature covered both patterns of seasonal variation in sea surface temperature, and seasonal occurrence of upwelling. Local upwelling occurred throughout the year but less frequently in winter. Diet and isotopic niche displayed little seasonal variation. Species-specific patterns of seasonal variation indicated distinct responses to environmental fluctuations. Temperature alone cannot explain the locality-specific variation in the nutritional ecology of herbivorous reef fish, and contrary to predictions that digestion in herbivorous fishes is impaired by cooler temperatures, no significant shifts in species’ nutritional ecology were detected.
Obstructive Sleep Apnoea as an Exacerbator of Vasospastic Angina
Authors: Michael Faith , Main Anthony , Kumar Andreas
Published: October 2023

Little is known about the association between obstructive sleep apnoea (OSA) and vasospastic angina. The authors report the case of a 47-year-old female with vasospastic angina who had a high symptom burden despite nitroglycerine and a calcium channel blocker. After a sleep study revealed severe OSA, the patient was started on continuous positive airway pressure. Following 8 weeks of continuous positive airway pressure, the patient reported remarkable improvement in their symptoms. This case suggests an under-recognised link between OSA and vasospastic angina. While further clinical research is required, screening and treatment of OSA may be beneficial for patients with treatment refractory vasospastic angina.
TÜRKİYE’DE DEZAVANTAJLI GRUPLAR VE İSTİHDAM
Authors: ERTÜRKMEN Gülferah
Published: October 2023

Bu çalışma dezavantajlı grupların çalışama yaşamı içerisindeki istihdam edilebilirlikleri değerlemeyi amaçlamaktadır. Dezavantaj, bazen fiziksel engellerden, bazen toplumsal değer sistemlerinden, bazen de işgücü piyasasının talep ettiği bilgi ve becerilerden yoksun olmaktan kaynaklanabilmektedir ve bu faktörler, ülkeden ülkeye büyük ölçüde değişiklik göstermektedir.

Dezavantajlı gruplar, çocuklar, engelliler, eski hükümlülükler, göçmenler, kadınlar ve yaşlıları kapsamaktadır. Çalışma yaşamı içerisinde çevre, bireysel özellikler, kültürel değerler, çalışma koşulları, eğitim, yaş gibi farklılıklar dezavantajlı grupların istihdam düzeyini belirleyen faktörler arasında sıralanmaktadır. Dezavantajlı grupları tanımlayan bu faktörler çalışma hayatında, bu gruplara dâhil olan bireylerin yerini belirlemektedir. Neoliberal politikaların da etkisiyle işten ayrılma, çalışma veya iş bulma sürecinde dezavantajlı gruplar ayrımcılığa maruz kalmaktadır. İstihdam, ülke düzeyinde hem ekonomik, refah ve sosyal uyumun bir göstergesidir. Yaşanan krizler sonrası işsizliğin artması ve buna bağlı olarak sosyal devlet ve sosyal koruma kavramlarının tekrar önem kazanması, dezavantajlı grupların istihdamı konusu uluslararası kuruluşların ve ülkelerin gündemlerine sık sık gelmektedir.
For the anniversary of Professor F. A. Bakhritdinova
Authors: Editorial Article
Published: October 2023

22 августа 2023 года исполняется 70 лет известному ученому, офтальмологу, заместителю председателя Ассоциации офтальмологов Узбекистана, профессору кафедры офтальмологии Ташкентской медицинской академии, доктору медицинских наук, профессору Фазилат Арифовне Бахритдиновой.
The results of a laboratory and clinical study evaluating the disinfecting properties multifunctional solution “OKVision GOLD” in relation to gas-permeable lenses
Authors: Myagkov A. V. , Averich V. V. , Bakalova N. A.
Published: October 2023

Introduction. The modern realities of the Russian market of contact lens care products dictate the search for a universal solution for one-stage cleaning, which has high disinfecting and cleansing properties for all types of contact lens materials.

Purpose: investigation of the disinfecting properties of the multifunctional solution “OKVision GOLD” in relation to scleral gas-permeable lenses.

Materials and methods. 20 patients (40 eyes) with keratoconus of various stages (average age 32.6 ± 2.3 years) were examined before and after wearing scleral lenses in the daytime. A clinical ophthalmological study was conducted, including a biomicroscopic assessment of the lens surfaces, as well as the anterior segment of the eye with the use of vital dyes before and after lens cleaning. In addition, smears were collected for further bacteriological examination. Evaluated: a) initial smear from the conjunctiva of the patient before putting on the contact lens; b) a smear from two surfaces of the lens after wearing it for 12 hours; c) a smear from two surfaces of the lens after 6 hours of treatment in solution. The place of analysis: G.N. Gabrichevsky research institute for epidemiology and microbiology.

Results. Sowing smears from the conjunctiva before using contact correction revealed the presence of opportunistic flora. Sowing after 12 hours of wearing lenses determined the attachment of pathogenic flora. Examination of smears from lens surfaces after their 6-hour exposure in solution revealed complete inactivation of previously detected pathogenic and insignificant presence of conditionally pathogenic flora. During biomicroscopy, the condition of the eye surface remained unchanged, no deposits on the lenses were recorded. The survey of patients also revealed no negative reactions.

Conclusion. The results of clinical and bacteriological studies indicate high disinfecting activity against conditionally pathogenic and conditionally pathogenic flora in the treatment of scleral lenses. This solution can be recommended for the care of all types of contact lenses, including gas-permeable ones.
Arabic-Hebrew Language-Switching and Cultural Identity
Authors: Ahmad Abdel-Fattah Mahmoud
Published: October 2023

The phenomenon of Arabic-Hebrew language-switching is increasingly prevalent among the Palestinian Arabs in “Israel”. This is a preliminary investigative study of Arabic-Hebrew language-switching which deals with the analysis of randomly selected pieces of discourse collected, for the purpose of the study, from various sectors of the Palestinian Arab population. The paper includes three main sections in which an attempt is made to answer the following three questions: (i) which parts of the community use language-switching distinctively in their everyday communication, (ii) what is the nature of such usage and the reasons behind it, and (iii) what is the relationship between language-switching and cultural identity?.
The Philosophical Deadlock in Iris Murdoch's The Bell and The Sea, The Sea
Authors: S. Sultan Sabbar
Published: October 2023

The fiction of the contemporary British novelist Iris Murdoch hinges on the successful mingling between the epistemological and philosophical on the one hand and the artistic and aesthetic on the other. There is an overriding and recurrent postulate in her fiction: the disparity between one's conscious and deliberate plans and what one eventually achieves. This philosophical view forms the constituent elements of two of her famous novels, The Bell (1958) and The Sea, The Sea (1978). This study explores the problematics of how this leitmotif is manifested in these two novels and the mechanism of showing that as well as the salient characteristics of her art and writing..
Vocabulary Knowledge and Reading Comprehension
Authors: Mebarki Zahia
Published: October 2023

The article reports the results of an investigation conducted with a group of Algerian university students majoring in Microbiology. Data for this study came from a reading comprehension test administered to proficient and less-proficient readers. The study addresses the following questions: (i) To what extent do high-level students differ from low-level students as far as vocabulary knowledge and comprehension are concerned? (ii) To what extent do measures of readers' vocabulary knowledge correlate with measures of reading comprehension? As regards the first question, the findings indicated that there were more differences than similarities between the two groups. Concerning the second question, the results of the test yielded an interesting finding indicating that a high performance on one implies also a high performance on the other, and a low performance in one implies a low performance in the other..
Persepsi Apoteker Tentang Penerapan Telefarmasi Di Apotek
Authors: Naufal Muhammad , Yuwindry Iwan , Rizali Muhammad
Published: October 2023

Latar belakang: Persepsi apoteker penting untuk mengetahui apakah suatu apotek dapat menerapkan telefarmasi, yang merupakan inovasi baru dibidang kefarmasian dan memerlukan adaptasi di penerapannya, khususnya di apotek untuk memberikan pelayanan kefarmasian berkualitas tinggi kepada masyarakat.

Metode: Pada penelitian ini menggunakan  metode kuantitatif dengan rancangan observasional analitik yaitu desain penelitian cross sectional dan teknik pengambilan sampel pada penelitian ini menggunakan teknik Consecutive Sampling.

Hasil: Berdasarkan hasil penelitian dengan 134 responden apoteker menunjukkan bahwa persepsi apoteker tentang penerapan telefarmasi di apotek menunjukkan hasil persepsi positif pada jaminan obat sebanyak 120(89,5%), pada harga obat memiliki persepsi positif sebanyak 107(79,8%), pada hak konsumen memiliki persepsi positif sebanyak 130(97%), pada kemudahan yang diperoleh menggunakan telefarmasi memiliki persepsi positif sebanyak 133(99,3%), pada regulasi yang mengatur telefarmasi memiliki persepsi positif sebanyak 133 (99,3%), dan pada resiko penjualan obat melalui aplikasi telefarmasi memiliki persepsi positif sebanyak 84(62,7%).Berdasarkan karateristik responden hanya sebanyak 32 (23,9%) apoteker yang menerapkan telefarmasi di apotek, dilihat dari ketertarikan apoteker untuk menerapkan telefarmasi di apotek sebanyak 101 (75,4%) apoteker tertarik untuk menerapkan telefarmasi.

Kesimpulan:  Persepsi apoteker tentang penerapan telefarmasi di apotek pada jaminan obat, harga obat, hak konsumen, kemudahan, regulasi, dan resiko telefarmasi adalah positif.

 

Kata Kunci:   Apotek, apoteker, persepsi, telefarmasi
Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune response
Authors: Borges Bruno Montanari , Ramos Rafael Berton Correia , Preite Nycolas Willian , Kaminski Valéria de Lima , Alves de Castro Patrícia , Camacho Maurício , Maximo Marina Ferreira , Fill Taicia Pacheco , Calich Vera Lúcia Garcia , Traynor Aimee M. , Sarikaya-Bayram Özlem , Doyle Sean , Bayram Özgür , de Campos Claudia Barbosa Ladeira , Zelanis André , Goldman Gustavo H. , Loures Flávio Vieira
Published: October 2023

Granulomas are important immunological structures in the host defense against the fungus Paracoccidioides brasiliensis, the main etiologic agent of Paracoccidioidomycosis (PCM), a granulomatous systemic mycosis endemic in Latin America. We have performed transcriptional and proteomic studies of yeasts present in the pulmonary granulomas of PCM aiming to identify relevant genes and proteins that act under stressing conditions. C57BL/6 mice were infected with 1x106 yeasts and after 8- and 12-weeks of infection, granulomatous lesions were obtained for extraction of fungal and murine RNAs and fungal proteins. Dual transcriptional profiling was done comparing lung cells and P. brasiliensis yeasts from granulomas with uninfected lung cells and the original yeast suspension used in the infection, respectively. Mouse transcripts indicated a lung malfunction, with low expression of genes related to muscle contraction and organization. In addition, an increased expression of transcripts related to the activity of neutrophils, eosinophils, macrophages, lymphocytes as well as an elevated expression of IL-1β, TNF-α, IFN-γ, IL-17 transcripts were observed. The increased expression of transcripts for CTLA-4, PD-1 and arginase-1, provided evidence of immune regulatory mechanisms within the granulomatous lesions. Also, our results indicate iron as a key element for the granuloma to function, where a high number of transcripts related to fungal siderophores for iron uptake was observed, a mechanism of fungal virulence not previously described in granulomas. Furthermore, transcriptomics and proteomics analyzes indicated a low fungal activity within the granuloma, as demonstrated by the decreased expression of genes and proteins related to energy metabolism and cell cycle.
Well-being and academic attitudes among secondary school students living in a context of life-threatening collective violence in Northern Nigeria
Authors: Shockden Eric Isaac , Bahago Beatrice A. , Omede Jacob
Published: October 2023

Collective violence limits well-being and academic achievement among the millions of young people in low- and middle-income countries who are exposed to armed conflict, terrorism, harassment, kidnapping, and other forms of communal violence. Most past research has focused on survivors or witnesses, neglecting the much larger number of young people who live under the prolonged threat of violence. This study addressed this gap by applying the Situated Expectancy-Value Model of adolescent academic achievement. This informed predictions about the relationship between well-being and adolescents’ orientation to formal education in a context of collective violence in which schools are a special target. Over the past decade, Northern Nigeria has experienced recurring terrorist attacks and large-scale abductions of school students. Students attending public secondary schools in Northern Nigeria (n = 371; male = 45.6%, age range = 16–17; mean age = 16.7 years) completed three questionnaires that assessed four domains of well-being (body image, self-esteem, a positive social orientation, and positive emotions), the perceived value of academic learning, and two behaviours strongly related to academic achievement (persistence and engagement). Multiple regression analyses found that the four domains of well-being accounted for 70.5%, 87.3%, and 88.3% of variance in the perceived value of academic learning, academic persistence, and academic engagement, respectively. Subsequent analyses revealed that the associations between multi-dimensional well-being and both persistence and engagement were partially mediated by the perceived value of academic learning. In summary, although the observational research design precluded conclusions about the direction of effect in associations between the variables, the results are consistent with the interpretation that psychological well-being allows students to appreciate the value of academic learning, and this contributes to higher academic engagement and greater persistence on academic tasks.
Immersive technologies as an innovative tool to increase academic success and motivation in higher education
Authors: Sviridova Ekaterina , Yastrebova Elena , Bakirova Gulmira , Rebrina Fayruza
Published: October 2023

The latest techniques and technologies significantly improve the academic performance, engagement, and motivation of students. VR and AR open up numerous opportunities for the educational system. The purpose is to evaluate the effectiveness of using immersive technologies as a tool to increase the level of academic success, involvement, and motivation among students. The research involved a total number of 180 students in two higher educational institutions. This study presupposed using a previously elaborated program for further use in the experimental group. This program was introduced into the study program within the participating universities. The study included three tests to collect the data under the Motivation and Engagement Scale, as well as European Credit Transfer and Accumulation System. The experimental group provided positive indicators during statistical data analysis; thus, it demonstrates the effectiveness of the studied methods. Although the engagement and motivation of students from the experimental group increased, there were no differences in academic achievements between the groups. Therefore, it cannot be argued that immersive technologies have a direct impact on grades, which are the main indicator of success in learning. The new experimental data obtained in this study and the analysis of previous modern experimental studies allowed us to draw relevant conclusions about the expediency and high efficiency of immersive education technologies for teaching university students.
The role of TRIM family in metabolic associated fatty liver disease
Authors: Zhang Jingyue , Zhang Yingming , Ren Ze , Yan Dongmei , Li Guiying
Published: October 2023

Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated. Tripartite motif (TRIM) protein is a kind of protein with E3 ubiquitin ligase activity, which participates in highly diversified cell activities and processes. It not only plays an important role in innate immunity, but also participates in liver steatosis, insulin resistance and other processes. In this review, we focused on the role of TRIM family in metabolic associated fatty liver disease. We also introduced the structure and functions of TRIM proteins. We summarized the TRIM family’s regulation involved in the occurrence and development of metabolic associated fatty liver disease, as well as insulin resistance. We deeply discussed the potential of TRIM proteins as targets for the treatment of metabolic associated fatty liver disease.
Modulation of fetoplacental growth, development and reproductive function by endocrine disrupters
Authors: Basak Sanjay , Varma Saikanth , Duttaroy Asim K.
Published: October 2023

Maternal endocrine homeostasis is vital to a successful pregnancy, regulated by several hormones such as human chorionic gonadotropin, estrogen, leptin, glucocorticoid, insulin, prostaglandin, and others. Endocrine stress during pregnancy can modulate nutrient availability from mother to fetus, alter fetoplacental growth and reproductive functions. Endocrine disrupters such as bisphenols (BPs) and phthalates are exposed in our daily life's highest volume. Therefore, they are extensively scrutinized for their effects on metabolism, steroidogenesis, insulin signaling, and inflammation involving obesity, diabetes, and the reproductive system. BPs have their structural similarity to 17-β estradiol and their ability to bind as an agonist or antagonist to estrogen receptors to elicit an adverse response to the function of the endocrine and reproductive system. While adults can negate the adverse effects of these endocrine-disrupting chemicals (EDCs), fetuses do not equip themselves with enzymatic machinery to catabolize their conjugates. Therefore, EDC exposure makes the fetoplacental developmental window vulnerable to programming in utero. On the one hand prenatal BPs and phthalates exposure can impair the structure and function of the ovary and uterus, resulting in placental vascular defects, inappropriate placental expression of angiogenic growth factors due to altered hypothalamic response, expression of nutrient transporters, and epigenetic changes associated with maternal endocrine stress. On the other, their exposure during pregnancy can affect the offspring's metabolic, endocrine and reproductive functions by altering fetoplacental programming. This review highlights the latest development in maternal metabolic and endocrine modulations from exposure to estrogenic mimic chemicals on subcellular and transgenerational changes in placental development and its effects on fetal growth, size, and metabolic & reproductive functions.