bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrosedimentological modeling in a subhumid tropical catchment and its interactions with phosphorus
Authors: Cavalcante Larissa , Silva Antonio Jose da , Mamede George
Published: December 2024

ABSTRACT This research aims to propose a method for estimating total phosphorus (TP) concentration in reservoirs based on relationships with water discharges and sediment load in regions with a lack of available data on TP load into reservoirs. The case study was the 45.4 km2 subhumid tropical catchment, located in the state of Ceará, with a 482,920 m3 outlet reservoir. The hydro-sedimentological modeling was performed using the process-oriented WASA-SED model (model of Water Availability in Semi-arid Areas with SEdiment Dynamics). Four sediment production models were tested (Universal Soil Loss Equation [USLE], Onstad-Foster, Modified Universal Soil Loss Equation [MUSLE], and Multiscale Soil Erosion Tool [MUST]), yielding decadal sedimentation rates in the Tijuquinha reservoir ranging from 2.8% to 15% per decade, with the best performance for MUST (7.2% decade−1) as compared with the data derived from bathymetric surveys carried out in 1992 and 2020 (7% decade−1). To estimate the TP input load during the wet season with inflow discharges, a phosphorus balance was performed considering measured data on TP concentrations at the reservoir. Thus, a phosphorus-discharge relationship was established, with an R2 of 0.58. Using the time series of water discharge generated with WASA-SED for the Tijuquinha catchment from 1980 to 2019, the historical TP load into the Tijuquinha reservoir was reconstructed for that period by applying the phosphorus-discharge relationship. The method proposed in this study was able to capture the intra-annual pattern of TP dynamics in the Tijuquinha reservoir, comparing monthly average values of measured and modeled TP concentrations. A specific TP input rate of 20.7 kg km−2 year−1 was found, with a TP deposition in the reservoir of 98.5% and a TP release by the outlet devices of 1.5%.
Degradation of aqueous mixture of textile dye via photo-Fenton process using bacterial cellulose/iron nanocomposite as catalyst
Authors: Silva Marina , Santana Ingrid , Henrique Mariana , Neves Naiana , Silva Fernanda Sobreira , Rodríguez-Díaz Joan Manuel , Vinhas Glória Maria , Napoleão Daniella
Published: December 2024

Abstract Given the great versatility of bacterial cellulose (BC), this work applied a BC/Fe nanocomposite as a catalyst in the photo-Fenton process to degrade the aqueous mixture of textile dyes direct black 22 and reactive blue 21. From the adsorption study on the BC/Fe nanocomposite, it was verified that there was no significant removal of dyes. However, when the nanocomposite was used with 100 mg·L–1 of H2O2 at an acidic pH (≈3.5), it effectively degraded the compounds. After 120 min, it achieved 77%, 83%, and 95% reduction in absorbance at λ of 266, 337, and 664 nm, respectively. Furthermore, it was noted that the experimental data fit well with the pseudo-first-order kinetic models for all monitored clusters. The study also revealed that iron replacement was necessary to maintain the catalytic efficiency of the BC/Fe nanocomposite. Additionally, toxicity tests showed that the treatment using the BC/Fe nanocomposite decreased the toxicity of the studied matrix against thyme and watercress seeds.
Comparison of salep orchid species based on the composition of the volatile compounds of their tubers
Authors: Şavşatlı Yusuf
Published: December 2024

Abstract The objective of this work was to compare salep orchid species based on the composition of the volatile compounds of their tubers. Tuber samples extracted by solid-phase microextraction were analyzed by gas chromatography-mass spectrometry. In all studied species, p-cresol was the main volatile compound detected. The highest p-cresol proportion was found in Anacamptis laxiflora (76.31%), followed by Ophrys sphegodes subsp. mammosa (62.72%), Orchis coriophora (55.95%), and Anacamptis pyramidalis (21.19%). The proportions of the other volatile compounds also varied significantly between the evaluated species. The clustering analysis of the species according to their volatile compounds showed that A. laxiflora and O. coriophora were the closest, while A. laxiflora and A. pyramidalis were the most distant.
Measles, mumps and rubella vaccination coverage in capitals and interior region municipalities of Northeast Brazil: a household survey in a cohort of children born in 2017 and 2018
Authors: Maciel Adjoane Mauricio Silva , Ramos Jr Alberto Novaes , Ferreira Anderson Fuentes , Silva Taynara Lais , Domingues Carla Magda Allan Santos , Saavedra Ramon da Costa , Barbosa Jaqueline Caracas , França Ana Paula , Kerr Ligia Regina Franco Sansigolo , Teixeira Maria da Gloria , Moraes José Cássio de , Silva Adriana Ilha da , Ramos Jr. Alberto Novaes , França Ana Paula , Oliveira Andrea de Nazaré Marvão , Boing Antonio Fernando , Domingues Carla Magda Allan Santos , Oliveira Consuelo Silva de , Maciel Ethel Leonor Noia , Guibu Ione Aquemi , Mirabal Isabelle Ribeiro Barbosa , Barbosa Jaqueline Caracas , Lima Jaqueline Costa , Moraes José Cássio de , Luhm Karin Regina , Caetano Karlla Antonieta Amorim , Lima Luisa Helena de Oliveira , Antunes Maria Bernadete de Cerqueira , Teixeira Maria da Gloria , Teixeira Maria Denise de Castro , Borges Maria Fernanda de Sousa Oliveira , Queiroz Rejane Christine de Sousa , Gurgel Ricardo Queiroz , Barata Rita Barradas , Azevedo Roberta Nogueira Calandrini de , Oliveira Sandra Maria do Valle Leone de , Teles Sheila Araújo , Gama Silvana Granado Nogueira da , Mengue Sotero Serrate , Simões Taynãna César , Nascimento Valdir , Araújo Wildo Navegantes de
Published: December 2024

ABSTRACT Objective To analyze measles, mumps, and rubella vaccination coverage among children up to 24 months old and factors associated with non-vaccination in a 2017−2018 live birth cohort, in state capitals and large interior region cities in Northeast Brazil. Methods Population-based survey analyzing vaccination coverage and sociodemographic factors through logistic regression. Results For 12,137 children, vaccination coverage was 79.3% (95%CI 76.5;81.8), and the dropout rate was 10.6%. Association with non-vaccination: socioeconomic stratum A (OR-a 1.29; 95%CI 1.10;1.50), living in the interior region (OR-a 1.22; 95%CI 1.07;1.39), no access to the Bolsa Família Program (OR-a 1.19, 95%CI 1.05;1.34), family income ≤BRL 1,000 (OR-a 1.17, 95%CI 1.03;1.31), mother not working (OR-a 1.28, 95%CI 1.15;1.42), >1 child per mother (OR-a 1.12, 95%CI 1.08;1.17), and no vaccination card (OR-a 10.69, 95%CI 6.27;18.20). Conclusion Low vaccination coverage and a high dropout rate in state capitals and municipalities in the interior region of Northeast Brazil.
Cobertura vacinal completa com doses válidas da coorte de nascidos vivos de 2017 e 2018 na região Sudeste do Brasil
Authors: França Ana Paula , Barata Rita Barradas , Guibu Ione Aquemi , Moraes José Cássio de , Silva Adriana Ilha da , Ramos Jr. Alberto Novaes , França Ana Paula , Oliveira Andrea de Nazaré Marvão , Boing Antonio Fernando , Domingues Carla Magda Allan Santos , Oliveira Consuelo Silva de , Maciel Ethel Leonor Noia , Guibu Ione Aquemi , Mirabal Isabelle Ribeiro Barbosa , Barbosa Jaqueline Caracas , Lima Jaqueline Costa , Moraes José Cássio de , Luhm Karin Regina , Caetano Karlla Antonieta Amorim , Lima Luisa Helena de Oliveira , Antunes Maria Bernadete de Cerqueira , Teixeira Maria da Gloria , Teixeira Maria Denise de Castro , Borges Maria Fernanda de Sousa Oliveira , Queiroz Rejane Christine de Sousa , Gurgel Ricardo Queiroz , Barata Rita Barradas , Azevedo Roberta Nogueira Calandrini de , Oliveira Sandra Maria do Valle Leone de , Teles Sheila Araújo , Gama Silvana Granado Nogueira da , Mengue Sotero Serrate , Simões Taynãna César , Nascimento Valdir , Araújo Wildo Navegantes de
Published: December 2024

RESUMO Objetivo Analisar fatores associados à cobertura vacinal completa com doses válidas, em crianças das capitais e em três outras cidades da região sudeste. Métodos Trata-se de análise de inquérito populacional conduzido em 2020-2021, em amostra estratificada segundo níveis socioeconômicos de crianças nascidas em 2017-2018, com dados coletados por registro fotográfico da caderneta de vacinação. Foram estimadas razões de chances (odds ratio, OR) e intervalo de confiança de 95% (IC95%) da cobertura vacinal completa pelas características da família, mãe e criança. Resultados Em 8.703 crianças, menor cobertura ocorreu nos estratos A e B (OR=0,39; IC95% 0,23;0,67 e OR=0,38; IC95% 0,25;0,58); nível de consumo A/B (OR=0,38; IC95% 0,28;0,52); renda mensal inferior a R$ 8.000,00 (OR=0,23; IC95% 0,12;0,42); em filhos de mães com ensino superior (OR=0,47; IC95% 0,32;0,71); em crianças não vacinadas exclusivamente no serviço público (OR=0,37; IC95% 0,26;0,51) e com atraso vacinal até 6 meses (OR=0,28; IC95% 0,22;0,37). Conclusão As coberturas não atingiram metas para controlar doenças imunopreveníveis e associaram-se negativamente ao maior nível socioeconômico.
ANÁLISE DE VIVÊNCIAS ESCOLARES DE PESSOAS TRANS NO ÂMBITO DA EDUCAÇÃO BÁSICA
Authors: Eduardo Rodrigues Martins Matheus , Pich Soares Helena , Cristina Bertazzo Silveira Vianna Thereza
Published: December 2024

O presente artigo objetivou a análise das vivências de pessoas transgênero, transexuais e travestis que se concretizam no cotidiano de escolas brasileiras. Neste sentido, discorre sobre não somente as experiências escolares de estudantes e professoras trans, mas também sobre temas que se interseccionam, como a infância e adolescência trans, a transmisoginia cotidiana das normas escolares de gênero e suas consequências a nível emocional, e a repercussão das violências transfóbicas para a prática profissional de educadoras transexuais e travestis. Fundamenta-se nos estudos transfeministas e na teoria decolonial. Deteve como metodologia a revisão integrativa de literatura, com buscas no portal de periódicos da CAPES, a qual selecionou quinze artigos. Compreendeu-se que a discriminação direcionada a dissidentes de gênero-sexualidade é uma realidade duramente presente nas escolas, sendo um mecanismo biopolítico, pautado na cisheteronormatividade, para controle e exclusão, levando estudantes trans ao sofrimento e evasão escolar. Ainda, professoras transgênero que constroem suas trajetórias na educação, rompendo com o estereótipo da mulher trans que vive da prostituição ou tão somente dela, são muitas vezes perseguidas por um Cistema social e educacional conivente com o assédio e a exclusão transfóbica. Entretanto, ressalta-se a agência de pessoas trans, com inúmeros relatos de resistência e (re)invenções frente às violências. Compreende-se que é dever da instituição escolar a construção de um ambiente de respeito e apoio, propiciando o decrescimento da evasão de pessoas trans, a promoção de ambientes seguros de trabalho para docentes trans e a necessária construção e promulgação dos saberes calcados nas dissidências de gênero e sexualidade.
The economic value of transport infrastructure in the UK: an input–output analysis
Authors: Kalyviotis Nikolaos , Rogers Christopher D. F. , Hewings Geoffrey J. D.
Published: December 2024

Transport infrastructure systems operate in, and are shaped by, the specific context in which they are expected to perform and contribute to the system-of-systems that support civilised life; they must strive to be sustainable and resilient. However, transport, one of the ‘economic infrastructures’, is viewed narrowly in political circles as a vehicle for economic prosperity: political focus falls on the economic pillar of sustainability. One perennial challenge concerns the inclusion of social and environmental value into such performance judgements. A deep understanding of system interdependencies is essential when comparing input–output tables (a top-down approach) with cost–benefit analysis (CBA, a bottom-up approach). CBA works best when there is adequate information to calculate a monetary value for all economic, social, and environmental outcomes, whereas input–output tables are most effective when environmental and social value are kept distinct from economic value and where the beneficial economic impacts extend across multiple sectors (CBA is inadequate in this regard). This research uses the World Input-Output Database and principal component analysis to develop a model to capture this complex accounting process. In recognising how past interdependencies inform future development, this study’s model provides new insights into indirect economic value creation within infrastructure systems.
ATP-Gated P2X7-Ion Channel on Kidney-Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation
Authors: Junge Marten , Liaukouskaya Nastassia , Schwarz Nicole , Pinto-Espinoza Carolina , Schaffrath Alessa Z. , Rissiek Björn , Krebs Christian F. , Rattay Guido , Mittrücker Hans-Willi , Tomas Nicola M. , Nicke Annette , Haag Friedrich , Huber Tobias B. , Meyer-Schwesinger Catherine , Koch-Nolte Friedrich , Wanner Nicola
Published: December 2024

Key Points

Parenchymal T cells in the kidney expressed much higher levels of P2X7 than vascular T cells.

P2X7-blocking nanobodies uncover a large fraction of kidney-resident natural killer T and tissue-resident memory T cells.

These cells were lost during cell preparation because of activation of P2X7 by NAD+ released from damaged cells, unless blocked by nanobodies.

Background

The P2X7 ion channel, a key sensor of sterile inflammation, has been implicated as a therapeutic target in GN, and P2X7-antagonistic nanobodies can attenuate experimental GN. However, little is known about the expression of P2X7 on renal immune cells.

Methods

We used conventional immunofluorescence of kidney sections and intraperitoneal injection of nanobodies in mice followed by flow cytometry analysis of parenchymal T cells and RNA sequencing to elucidate the expression and function of P2X7 on parenchymal and vascular immune cells in the mouse kidney.

Results

Our study showed that parenchymal T cells, including a large subset of natural killer T cells and CD69+ tissue-resident memory T cells, display much higher cell surface levels of P2X7 than vascular T cells. After a single intraperitoneal injection of P2X7-blocking nanobodies, P2X7 on parenchymal T cells was fully occupied by the injected nanobodies within 30 minutes. This resulted in an effective protection of these cells from nicotinamide adenine dinucleotide–induced cell death during cell preparation. Conversely, systemic injection of nicotinamide adenine dinucleotide that mimics sterile inflammation results in the selective depletion of P2X7hiCD69hi T cells from the kidney parenchyma.

Conclusions

Our study uncovered a novel purinergic regulatory mechanism affecting kidney-resident T-cell populations.
Operatoria dental: bases para una buena práctica
Authors:   author, Arango Betancur Luz Mónica , España Jorge Rolando
Published: December 2024

A wide variety of oral rehabilitation treatments are performed in current dental
practice, including operative dentistry procedures. In this area, the dental professional
performs definitive treatments using dental biomaterials, including dental
composites, amalgams, glass ionomer cements, among other materials, to protect
the dentin-pulp organ with the purpose of protecting the patient´s health status.
Operative dentistry procedures must be performed due to the presence of caries,
congenital conditions or dental trauma that destroy the tooth or a part of it. These
procedures are intended to restore the form and function of affected teeth and, in
most cases, their aesthetics.
Operative dentistry procedures are one of the first restorative treatments performed
by students at the Faculty of Dentistry, Universidad Cooperativa de Colombia,
Medellin-Envigado campus. Therefore, this book has been designed as a facilitating
tool for undergraduate students to learn and achieve their competences in a simulated
environment to apply the acquired knowledge later on during their clinical
practice.
The main purpose of this book is to develop the necessary clinical criteria in dental
students to carry out an integral dental practice by providing a theoretical support
that enables them to develop clinical skills in operative dentistry procedures.
Some of the topics in the book include the identification of dental instruments
employed in operative dentistry procedures, the differentiation and analysis of
general, biological and mechanical principles of tooth preparations to propose an
assertive treatment plan according to the patient´s own situation, the classification
of different cavity preparation designs according to the location and extension of the
carious lesion or defect, the management of the operative times that involve
the final restoration of a tooth and all the biomaterials and their indications for the
different clinical situations that may be present in a patient.
Deneysel Baskıresim Üzerine Bir Eylem Araştırması
Authors: Aydoğan Yeşim
Published: December 2024

Denemeler ve deneyler hemen hemen tüm disiplinlerde, yenilikçi ve yaratıcı fikirlerin ardından ortaya çıkmış ve çıkmaya devam etmektedir. Nitekim sanat alanında da bu durum farklı değildir. Özellikle özgürlükçü, yenilikçi, farklı, kural tanımaz zihinlerde açığa çıkan bilinmeyene karşı duyulan merak, yaratıcı bakış açısıyla birlikte, deneysel çalışmaların ortaya çıkmasına sebep olmaktadır. Yaratıcılığın yeniyi üretme, belirsizliği çözümleme, bilinmeyeni bulma, denenmemişi deneyimleme gibi duygu, düşünce ve isteklerden doğuyor olması, deneyselliği beraberinde getirmektedir. Bu deneysellik, yaratıcı bakış açısı perspektifiyle ele alındığında, her disiplinde çeşitli şekillerde varlık göstermektedir. Söz konusu varlık durumu, kendisini konu, içerik, teknik, malzeme ve daha birçok yönden göstermektedir. Deneysel baskı da, tüm bunları içerisinde barındıran bir yöntemdir. Nitekim deneysel baskı, özellikle kural tanımazlığın bir getirisi olarak, sınırsız malzeme ve teknik ile her türlü deneyselliğe imkân tanımaktadır. Zira plastik sanatlarda alışılmadık her türlü boya, malzeme, çeşitli üslup ve tekniklerle bir arada kullanılarak, estetik, pitoresk ve zengin plastik değerler, deneysel arayışlarla ortaya çıkarılmaya çalışılmaktadır. Bu araştırma da, Baskı Teknikleri I dersi kapsamında gerçekleştirilmiş ve araştırma kapsamında yapılan deneysel baskılara yönelik değerlendirmelerde bulunulmuştur. Nitel araştırma perspektifinde yürütülen bu çalışmada, desen olarak eylem araştırması modeli belirlenmiştir. Bu araştırma, “Malzeme Zenginliği, Kompozisyon Oluşturma, Rastlantısal Oluşumlar, Dokusal Oluşumlar, Yaratıcı Fikirler, Estetik Sorgulamalar” olmak üzere toplam altı ana temadan oluşmaktadır.
Topic resumption in Bamiléké Ngemba: Animate/inanimate asymmetries and strictly local Impoverishment
Authors: Fongang Leonel Tadjo
Published: December 2024

Ngemba displays an interesting asymmetry in topicalization. Unlike subject topics, which are always resumed, object topics can only be resumed if the topic XP is animate. If it is inanimate, the presence of a resumptive pronoun is ungrammatical, unless the topic XP is a member of a conjunct (&P). In this paper, I argue that the absence of resumptive pronouns (RPs) with inanimate objects results from an Obliteration rule (Arregi & Nevins 2012) that deletes the OBJRP node when it has the features [TOP, INAN], among others. I propose that this rule is structurally constrained by sisterhood to V, such that it fails to apply to members of conjuncts because they are inside a &P. Overall, the Ngemba data call for a theory of resumption that goes beyond chain reduction (van Urk 2018; Scott 2021; Georgi & Amaechi 2023; Yip & Ahenkorah 2023). The analysis also strengthens the theoretical observation that impoverishment rules are (and need to be) featurally (Nevins 2011; Arregi & Nevins 2012; Keine & Müller 2020, among others) and structurally (Kallulli & Trommer 2011; Bobaljik 2012; Božič 2020; Fongang 2024) constrained.
Colapso climático en la región andina. Dimensiones ecosistémicas, socioeconómicas y sociopolíticas
Authors:   Universidad Politécnica Salesiana, Ecuador
Published: December 2024

Este libro, resultado de la colaboración entre la Universidad Politécnica Salesiana de Ecuador y la Friedrich Alexander Universität de Erlangen-Nürnberg, ofrece una visión integral y multidisciplinar del cambio climático en la región andina. Abarca desde los ecosistemas únicos hasta las dinámicas sociales y políticas que afectan a las comunidades, invitando a reflexionar sobre cómo esta crisis global transforma una de las zonas más diversas del mundo. Basado en investigaciones presentadas en una conferencia internacional en Alemania, y en estudios recientes, el texto no solo explica el impacto del calentamiento global en los ecosistemas, como los bosques secos y las zonas costeras, sino que también aborda custiones humanas clave: ¿cómo perciben y enfrentan las comunidades indígenas y urbanas los cambios climáticos? ¿Qué papel juegan el género, la etnicidad y la política en las estrategias de adaptación? Con un enfoque científico sólido, pero accesible, este libro busca responder a esas preguntas desde una perspectiva interdisciplinar. Además, explora las tendencias actuales en los países andinos, reflexionar sobre los desafíos del colapso climático y considerar soluciones transformadoras basadas en la resiliencia y la cooperación.
Hogyan segítik a digitális érzékelők az állatjólét javítását – legeltetett húsmarhaállományon keresztül bemutatva
Authors: Biszkup Miklós , Balogh Petra , Babay-Török Barbara , Pajor Gábor , Márton Aliz
Published: December 2024

Vizsgálataink során többek között arra kerestük a választ, hogy a kereskedelmi forgalomban kapható, digitális adatgyűjtésen alapuló szenzorok alkalmazása során hogyan kísérhetjük nyomon és fokozhatjuk az extenzíven tartott húsmarhák állatjóléti paramétereit. Ennek érdekében 120 charolais tehenet és szaporulatát szereltük fel különböző érzékelőkkel, melyek kiválasztásánál fő szempont volt, hogy eltérő testtájon helyezkedjenek el és különféle adatokat szolgáltassanak. A beérkező adatok gyakorlatilag láthatóvá teszik számunkra a láthatatlant, megtudhatjuk, hogy mikor és mi történik a legelőn. A szenzorok többek között kérődzési-, aktivitási-, testhőmérséklet- és helymeghatározási adatokat szolgáltatnak, melyekből napi jelentést készítünk a gazdáknak. Az adatok alapján egyed- és állomány szinten is nyomon követhetjük az állatok egészségügyi állapotát. A valós idejű adatoknak köszönhetően probléma esetén gyorsan és hatékonyan lehet beavatkozni. A szenzoros adatgyűjtés lehetőséget ad az ivarzások nyomon követésére, természetes pároztatás (bikás termékenyítés) esetén az ellések időpontjának meghatározására. Ezt kiegészítve kamerás megfigyeléssel hatékonyan kiszűrhetők az ellési komplikációk, ezáltal csökkenthető a születés körüli borjúelhullás. Tapasztalataink alapján a szenzoros technológiák jelentősen segítik az állatjólét javítását legeltetett körülmények között, a kapott információkkal egészségesebb és stresszmentesebb állományt alakíthatunk ki.
A fajta és a szaporodásbiológiai menedzsment hatása a termékenységi mutatókra automatikus fejőrendszerekben
Authors: Holló Gabriella , Bús Bence , Szabari Miklós
Published: December 2024

Jelen tanulmány, két tejhasznú fajta (holstein-fríz, magyartarka) reprodukciós teljesítményének vizsgálatát tűzte ki célul különböző szaporodásbiológiai protokoll (az ellés után 50.-60. nap között szinkronizált, az ellés után 90.-100. napon szinkronizált, nem szinkronizált) alkalmazása esetén automatikus fejőrendszerekben. Három különböző tenyészetben, 807 tejelő tehén 6610 fejési rekordját elemezték. A 90-100. napon szinkronizált magyartarka fajtában volt a a legkedvezőbb a vemhesítéshez szükséges inszeminálások száma. Az 50-60. nap között szinkronizált holstein-fríz teheneknél volt a legrövidebb az elléstől az első inszeminálásig terjedő időszak. A vemhesülési arány 39,2% és 57,7% között mozgott. Az ellést követő 90 napon belül vemhes, első laktációs tehenek aránya 46,5% és 70,8% között változott. A laktáció 150. napjáig a tejmennyiség és annak beltartalmi értékeit összevetve, mindhárom állomány esetében az eltérő szaporodásbiológiai státusznak statisztikailag igazolt hatása volt a tejhozamra és a fehérjetartalomra. Megállapítható, hogy a nagy tejtermelő képességű holstein-fríz állomány termékenységi mutatói rosszabbak voltak, de úgy tűnik, hogy a szinkronizálás a reprodukciós tulajdonságokat kedvezően befolyásolta az egyszer ellett tehenek esetében. A szaporodásbiológiai státusz különbségei a tej összetételében is változást eredményeztek, de a kapott eredményeket még további vizsgálatokkal kell megerősíteni.
Hormonmentes ivarzásindukciót elősegítő természetes növényi hatóanyagú kapszula elővizsgálata három különböző juh genotípus esetében
Authors: Fúró Gabriella , Csízi István , Bodnár Ákos , Pajor Ferenc , Egerszegi István
Published: December 2024

Vizsgálatunk három juh genotípus szaporodási mutatóit hasonlítja össze egy hormonmentes természetes növényi hatóanyag-tartalmú kapszula, a Janova hatására. A kísérletbe összesen 120 anyajuhot vontunk be, melyek fele kapott kezelést a következő genotípusok szerint: berrichon du cher (berrichon, n=20), blanc du massif central (BMC, n=20) és magyar merinó (merinó, n=20). A vizsgált állomány másik fele volt a kontroll csoport, genotípusonként szintén 20-20 anya. Statisztikailag (P>0,05) nem találtunk szignifikáns kapcsolatot a kezelés és a szaporodásbiológiai mutatók között sem a genotípusok esetében, sem összességében, vagyis az anyák hasonlóan teljesítettek. A szaporulati arány a berrichon, bmc és merinó anyéknál a kezelésekben 75%, 115% és 135% volt, és a kezeletlen csoportokban 65%, 95% és 120%. A szaporasági arány a kezelt berrichon, bmc és merinó anyáknál 115%, 153% és 150% volt, míg a kontroll csoportoknál 108%, 136% és 141% volt. A berrichon és BMC anyák jelentős hányada nem ellett (25-40%), míg ugyanez a merinó anyák 10-15%-nál fordult elő. A született bárányok ivarának aránya hasonló volt a genotípusokon belül a kezelt és a kezeletlen csoportban. Statisztikailag nem igazolható kapcsolat ellenére bíztató adatokat rögzítettünk a kezelt csoportok szaporulati és szaporasági mutatóit, valamint a született bárányok számát tekintve, ezért további vizsgálatokra van szükség a kapszula hatékonyságának pontosabb meghatározásához.
REDI-NET W-2 WATER PROCESSING v2
Authors: Consortium REDI-NET
Published: December 2024

OBJECTIVE To outline procedures for total nucleic acid extraction from water samples. SUMMARY/SCOPE The overarching aim of the REDI-NET is to develop a collaborative laboratory network between domestic and international partnering institutions to address disease surveillance needs in order to effectively detect, predict and contain potentially emergent zoonosis. This SOP provides guidance on procedures for total nucleic acid extraction from water samples to allow downstream library preparation and sequencing for pathogen detection.
USDA LTAR Common Experiment measurement: Cropland plant diversity v1
Authors: J. Wilke Brook , Boughton Elizabeth
Published: December 2024

Couple this protocol with the USDA LTAR Common Experiment measurement: Aboveground biomass protocol to estimate plant species composition and abundance in LTAR Croplands Common Experiment plots and fields. Perform measurements by separating the destructive biomass sample by individual species (preferred) or visually assessing plant species in the sample area before destructive sampling.
REDI-NET L-2 LEECH PROCESSING v2
Authors: Consortium REDI-NET
Published: December 2024

This protocol details leech processing for total nucleic acid extraction.
REDI-NET F-2 FECES PROCESSING v2
Authors: Consortium REDI-NET
Published: December 2024

This protocol details feces processing.
Evaluation of Scalability of Distributed Systems based on Algorithms for Iterative Task Execution with Coordination via Key-Value Storage
Authors:   Moscow Polytechnic University, Moscow, 107023, Russian Federation, Zeynally T. E. , Demidov D. G. ,   Moscow Polytechnic University, Moscow, 107023, Russian Federation
Published: December 2024

This paper presents the results of research aimed at evaluating the scalability of distributed fault-tolerant systems for iterative task execution. The study focuses on peer-to-peer distributed systems capable of executing tasks iteratively according to a schedule, where the nodes are coordinated through a key-value store. The operation of such systems is based on Recurrent Worker Service (RWS) algorithms. The primary focus is on studying the dependency of metrics such as iteration accuracy and resource utilization on the number of system nodes, including both application and storage nodes. The experimental environment is deployed in Yandex Cloud infrastructure and consists of four servers, one of which is low-performance and three are high-performance. Tests were conducted under three scenarios: application node scalability, storage node scalability, and simultaneous scalability of both node categories. During the tests, performance differences between the two modes of RWS algorithms were studied. The results obtained in this work can be used in the design and optimization of distributed systems that require high performance and fault tolerance.
A Model of Two-Group Conflict in R&D Processes at the Enterprise
Authors:   Ufa University of Science and Technology, Ufa, 450076, Russian Federation, Orlova E. V.
Published: December 2024

The purpose of the study is to substantiate the possibility and potential effects of using a new approach and class of models based on sociophysical analogies for modeling and managing conflicts in the business processes of research and development of an organization. A research methodology is proposed, based on the modern post-non-classical paradigm (synthetic picture of the world), formed on the principles of global evolutionism, interdisciplinarity, openness and nonlinearity; sociophysical approach for studying social conflicts and their modeling; historical method of study­ing social phenomena in time and determining the connection between past, present and future, critical-dialectical method of analyzing contradictions of social groups as a source of change, methods of system analysis of conflict as a complex process self-developing over time and system synthesis to resolve social contradictions in the process of development and implementation innovation of the organization. It is shown that employees of an organization can be divided into two groups depending on their attitude to new ideas, technologies and style of behavior when solving new creative problems — innovators and adapters. When developing and implementing innovations, project teams should include workers of both types. The presence of workers in the same team with antagonistic positions can lead to conflict situations. It is substantiated that for the modeling and management of such social conflicts, methods and models of sociophysics can be applied, providing a representation of the conflict as a change in behavioral reactions, and aimed at ensuring the cohesion of group members and their depolarization. The significance of the study is the ability to analyze the contradictions of interests of participants in the process of their interactions when implementing the tasks of developing and implementing innovations based on a sociophysical approach. The developed methodology takes into account the identified features of research and development processes, as well as complex intra-group and inter-group connections of conflicting groups, and allows us to develop requirements for modeling processes of conflict interaction and forecasting the options and nature of its development.
Parasocial Intimacy, Change, and Nostalgia in Podcast Listener Reviews
Authors: Vilceanu M. Olguta
Published: December 2024

As the medium of podcasting reaches maturity, exploring the evolving nature of parasocial intimacy, nostalgia, and change is crucial. With the podcasting industry increasingly focused on financial viability, listener loyalty and nostalgia are critical components in podcast audience studies. Listener reviews are an integral part of this research. This study enriches podcast audience studies by investigating the connection between the parasocial relationships of trust and intimacy listeners develop with show hosts and nostalgic reactions to show changes. Using automated semantic network analysis of over 12,000 podcast reviews for two of the longest-running and best-regarded US podcasts, this study has confirmed the pivotal role of the show host and content in developing and maintaining the parasocial rapport of intimacy and trust with listeners. It also revealed that changes in the show’s host(s) or content trigger nostalgic reactions, which can be positive or negative. These findings have significant implications for long-lived podcasts as they approach the stage when host or content changes become inevitable, thereby underscoring this study’s practical relevance and importance for the podcasting industry.
Features of the course of non‑small cell lung cancer and the percentage of lymphocytes in the blood of patients who had recovered from COVID‑19
Authors: Zhukova G. V. , Frantsiyants E. M. , Kharagezov D. A. , Shikhlyarova A. I. , Kaplieva I. V. , Mirzoyan E. A. , Milakin A. G. , Lisunova Z. P. , Avanesova K. A.
Published: December 2024

Purpose of the study. This study aimed to identify the characteristics of the course of cell lung cancer (LC) and the information content of the indicators of the adaptation status of patients of different sexes who had COVID‑19, confirmed by PCR diagnostic results before the start of antitumor treatment.

   Patients and methods. We have studied traditional clinical and laboratory parameters, and the white blood cell count in patients with non‑small cell LC st. I–III, men (59) and women (32) aged 36–75 years. The main groups included 32 men and 16 women who had COVID‑19, confirmed by real‑time PCR, 2–9 months before hospitalization. Patients in the control groups denied having a history of diagnosed COVID‑19. Before the start of antitumor treatment, the percentage of lymphocytes in the blood was assessed. Cases of LC progression and mortality within a year after antitumor treatment were noted.

   Results. In men of the main group a 2.7‑fold increase (p < 0.05) in cases of early lung cancer stagings with a simultaneous tendency towards an increase in the number of incidences of metastasizing and mortality within a year after inpatient treatment in comparison with control indexes were observed. Signs of disease severity worsening and a decrease in the effectiveness of treatment were observed without significant changes in the ratio of the patients with tumors of various stagings in female patients. In patients of the main groups, a disturbance of the correspondence between the percentage of lymphocytes and the prevalence and dynamics of the malignant process was noted. In men of the main group who died within the first year after the end of antitumor treatment, the percentage of lymphocytes before the start of treatment reached 28–45 %, corresponding to antistress adaptational reactions, 4 times more often than in the control group (p < 0.01)

   Conclusion. COVID‑19 flow before the start of LC treatment contributes to a decrease in the body's antitumor resistance and a violation of the informativeness of the percentage of blood lymphocytes as an indicator of adaptation status. Changes depend on sex. In women, the observed changes reflected an aggravation of the malignant process and systemic disorders, as well as a decrease in the effectiveness of treatment. In men, a sharp increase in the number of cases of one year mortality with high percentage of blood lymphocytes before the start of treatment, as well as the number of cases of early‑ stage LC, indicates a more significant change in the state of lymphocytes compared to that observed only in LC, as well as the possibility of acceleration of the transition of precancerous cells into malignant process in the lungs under the influence of a previous coronavirus infection.
DIGITAL TRANSITION AS A DRIVER OF BUSINESS MODEL TRANSFORMATION: CONCEPT AND IMPLEMENTATION PATHWAYS
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Lisova R. M.
Published: December 2024

This article examines the digital transformation of business models in the context of the digital transition, particularly within the Ukrainian framework. It analyzes key approaches and tools for digital transformation that enable companies to adapt their strategies and operational models to the challenges of the digital economy. As digital technologies change the ways of creating value, interacting with customers, and internal business processes, enterprises face the need to modernize their business models to maintain competitiveness and efficiency in the market.

Special attention is given to the adaptation of the Business Model Canvas, proposed by A. Osterwalder and I. Pigneur, to the conditions of the Ukrainian market. This tool, widely used in global practice, allows for a structured approach to building business models and evaluating the impact of digital technologies on their core components. The aim of the article is to explore the potential use of this tool for adapting Ukrainian enterprises to the new demands of the digital economy. The article discusses in detail the components of the adapted Business Model Canvas, taking into account the specifics of the Ukrainian market, including support for local producers, emphasis on social responsibility, and increased focus on cybersecurity.

Based on the analysis, the digital transformation requires a comprehensive approach that includes three main paths: the integration of digital operations, the restructuring of the value proposition, and the comprehensive transformation of business. At the same time, during the adaptation process, companies encounter various barriers, including socio-cultural and psychological factors, which may limit employees' readiness for change. The impact of external factors, such as economic, political, and regulatory conditions, is also crucial, requiring the development of tailored strategies for effective transformation.

As a result of the study, recommendations are made for the use of the adapted Business Model Canvas for Ukrainian enterprises, which will help them better integrate digital technologies into their strategies and business processes. The identified critical factors for successful adaptation and transformation provide practical recommendations for businesses of various sizes, particularly small and medium enterprises, in implementing digital solutions and supporting sustainable development in the face of continuous change.
Enhanced high step-up Zeta-converter for photovoltaic connected grid system
Authors:   Sir CR Reddy College of Engineering, Deepti Prasanna Tata , Sripriya Ravi ,   Annamalai University, Bhupesh Kumar N. ,   Annamalai University
Published: December 2024

A power electronic converter known as a Zeta-converter is widely utilized in various applications, including renewable energy systems, power supply, and electric vehicles. Despite its advantages in photovoltaic source conversion, such as single-stage power conversion and power factor adjustment, conventional Zeta- converters face limitations in efficiency and adaptability due to their narrow working range and additional circuitry. To address these challenges, this research proposes an enhanced high step-up Zeta-converter architecture tailored for grid-connected PV systems. The suggested converter offers exceptional power factor adjustment and can handle a broad range of input voltages, ensuring optimal performance even under varying environmental conditions. By actively aligning the input current with the input voltage, the converter achieves a power factor close to unity, minimizing harmonic content and enhancing system efficiency. Additionally, interleaved operation reduces switching noise and voltage spikes, leading to decreased electromagnetic interference emissions. This makes the proposed converter highly suitable for grid-connected PV systems, where reliable power conversion and high-quality energy delivery are paramount. The versatility of the converter makes it applicable not only to PV systems but also to other scenarios requiring a greater output voltage than input voltage, such as LED drivers or certain DC-DC conversion applications.
Risks of health consequences of terrorist activity in Russia in 2011–2020
Authors: Evdokimov Vladimir I. , Shulenin Nikolay S.
Published: December 2024

The indicators of the medical and sanitary consequences of terrorist acts in Russia are presented, indexed in the Global Terrorism Database by employees of the National Consortium for the Study of Terrorism and Response Measures, the Ministry of Emergency Situations of Russia and the Ministry of Health of Russia from 2011 to 2020. Individual risks of being exposed to terrorist acts, dying or being struck per 1 million people are calculated (10–6) of the Russian population. The average data and medians with upper and lower quartiles are presented. Compared with the global risks of terrorist activity in Russia, according to the National Consortium for the Study of Terrorism and Measures to Respond to it, the Ministry of Emergency Situations of Russia and the Ministry of Health of Russia belong to the category of “optimal”. At the same time, the polynomial trends of the analyzed risks at very high coefficients of determination demonstrate a clear decrease in data. The main purpose of terrorism is to destabilize the activities of government agencies and public organizations, to intimidate people, and not the health consequences. However, using the data of risk indicators for counter-terrorism measures, including for counter-terrorism medicine, it can be minimized. It is necessary to carry out more extensive interstate interaction between employees who take into account terrorist acts and their social, biomedical and economic consequences in Russia, with employees of the National Consortium for the Study of Terrorism and Measures to Respond to it and other international organizations. Objective accounting of indicators of terrorist activity makes it possible to identify temporal and spatial patterns, vulnerable groups and objects, as well as ways and means of attacks. This helps to develop targeted preventive measures and strategies to counter terrorist activity aimed at eliminating the identified causes and reducing the risk of terrorist acts.
Approach to neurosurgical care for combat-related injuries to the peripheral nervous system
Authors: Gaivoronsky Alexey I. , Svistov Dmitrii V.  , Kolomentsev Sergey V. , Ovchinnikov Dmitrii V. , Ivchenko Evgeniy V. , Onnintsev Igor E. , Priymak Maxim A. , Churikov Leonid I. , Isaev Dzhamaludin M. , Alexeev Evgenii D. , Isengaliev Ilyas N. , Petrenko Elizaveta A.
Published: December 2024

Gunshot and landmine wounds to the upper and lower extremities are the most common injuries in modern armed conflict. In previous armed conflicts, reconstructive surgery of peripheral nerves was not performed until 3-6 months after injury because dysfunction was often associated with a contusion mechanism of injury and recovery of nerve function may occur without surgical treatment. A new approach to care for patients with peripheral nerve injuries was developed and implemented by the authors. In recent years, the Military Medical Academy has widely used neuroimaging diagnostic techniques, such as magnetic resonance neurography and ultrasound examination of peripheral nerves. They can confirm or rule out a complete anatomical rupture of the nerve trunk. In the presence of characteristic pathomorphologic changes, peripheral nerve reconstructive surgery is performed as early as possible after injury (1.0–1.5 months). The earlier the nerve is reconstructed, the faster and more complete the functional recovery. Care of patients with peripheral nerve injury requires a comprehensive approach and close collaboration between neurosurgeons and related specialists. Such an approach allows identifying peripheral nervous system injuries in incoming surgical patients. This approach has proven effective in the treatment of neuropathic pain in this population. Early reconstructive intervention increases the effectiveness and decreases the time to regain lost limb function, thus shortening the rehabilitation period and improving quality of life.
Composition and toxicity of damaging fragments in gunshot and mine-blast spine injuries
Authors: Orlov Vladimir P. , Nashchekina Yuliya A. , Nashchekin Alexey V. , Mirzametov Saidmirze D. , Idrichan Sergey M. , Kravtsov Maxim N. , Svistov Dmitry V.
Published: December 2024

The feasibility of removing damaging fragments from the spine in gunshot and mine-blast injuries is assessed based on the data of their composition and cytotoxicity. Four damaging fragments removed from the spine and paravertebral tissues were analyzed. Elemental analysis was performed using a scanning electron microscope. The composition of the damaging fragments was studied using spectral analysis. The cytotoxicity of the medium with damaging fragments was evaluated using the methyl tetrazolium test, comparing to the control medium. Morphological changes in cells were assessed using optical light microscopy, comparing to the control. Elemental analysis showed that all studied fragments consisted of alloys of various metals and other chemical elements. During the first few weeks of incubation in a complete nutrient medium, metals underwent fairly active oxidation, producing an orange precipitate. During further incubation, the oxidation of metals continued quite intensively, leading to a change in the nutrient medium and reducing cell proliferation. Moreover, morphological examination showed that cells exposed to metal oxides were rounded, while control sample cells were elongated and spindle-shaped. The methyl tetrazolium test revealed high cytotoxicity of all the fragments studied. All fragments were found to release toxic metal oxides into the nutrient medium, significantly reducing cell viability, regardless of their elemental composition. To prevent complications associated with possible local and/or systemic toxicity of metal fragments, as well as early and late infections, it is recommended to remove projectiles to the maximum extent feasible.