bluuebunny/crossref_metadata_2025 huggingface dataset:
The implication of Synemin gene on expression and prognostic significance in gastric cancer based on bioinformatics
Authors: Pan Feng , Zhang Yong-Qiang , Zhang Xu-Dong , Li Xiao-Ning , Cui Hai-Kang , Yan Xi , Yan Lan , Zhang Wen-Jie
Published: August 2023

Objective：Here, we explored the expression of SYNM by means of Gene Expression Omnibus (GEO) and investigated its prognostic significance as well as potential functions in gastric cancer (GC).Methods：Toward this goal, differential gene expression analysis, univariate Cox regression, Lasso regression, best subset regression, Gene Set Enrichment Analysis (GSEA) and multivariate Cox regression were employed in GEO. For further verification, the pathological tissues of patients with gastric cancer were collected and analyzed. The expression of SYNM in GC tissues was verified by qRT-PCR, Western blotting and immunohistochemistry. Kruskal-Wallis test was used to analyze the correlation between SYNM expression and clinical characteristics. Kaplan-Meier analysis, univariate and multivariate Cox regression analysis were applied to analyzed prognostic.Results：SYNM is underexpressed in GC in public datasets and clinical samples (P <0.01); Its expression was significantly correlated with Lauren typing, T, N, M and clinical staging (P <0.05). Patients with high SYNM expression had poor prognosis (P <0.01) and it was an independent prognostic factor for GC (p = 0.01). The high expression of SYNM mRNA was enriched in Extracellular matrix (ECM) receptor interaction, leukocyte transendothelial migration and Transforming growth factor β (TGF – β) signaling pathway, and CD4+ memory T cells resting were abundant.Conclusion：SYNM was low expression in GC and it might promote the malignant development and immune evasion of GC, and patients with high expression of SYNM predicted a good prognosis.
Emotion Recognition and Processing Deficits in Children with High Callous-Unemotional Traits: The Role of the MAOA Gene
Authors: Muratori Pietro , Palumbo Sara , Vellucci Stefano , Mariotti Veronica , Billeci Lucia , Levantini Valentina , Inguaggiato Emanuela , Masi Gabriele , Milone Annarita , Pellegrini Silvia
Published: August 2023

Children with high Callous-Unemotional (CU) traits show deficits in recognizing and processing facial expressions. Alterations in emotion recognition have been linked to a higher synaptic concentration of monoaminergic neurotransmitters. The current study investigated the relationship between the MAOA-Low-activity alleles and the ability to recognize and process facial expressions in 97 male children (8-12 years old) diagnosed with disruptive behavior disorder. Participants completed a computerized emotion-recognition task while an eye-tracking system recorded the number (Fixation Count, FC) and length (Fixation Duration, FD) of fixations to the eye region of the emotional stimuli. Children with high CU traits exhibited lower scores in recognition of sadness and anger, and lower FC and FD for sadness and fear than children with low CU traits. Children carrying the MAOA-Low-activity alleles displayed lower FD for sadness, and FD and FC for fear than those carrying the MAOA-High-activity alleles. These genetic effects appeared even stronger in children with CU traits. Moderation analysis revealed that CU traits were associated with lower FC and FD for fear, and lower FD for sadness, probably due to the MAOA-Low-activity alleles. Our findings, although to be replicated, suggest MAOA-Low-activity alleles as potential genetic biomarkers to identify CU children in need of training focused on emotion processing.
POST-DIVORCE DISTRIBUTION OF COLLECTIVE ASSETS IN INDONESIA VIEWED FROM NATIONAL LAW (STUDY OF CIVIL COURT DECISION NUMBER 2354/PDT.G/2019/PA.PWT)
Authors:   Master Student,FacultyofLaw,JenderalSoedirmanUniversity, Indonesia., a Septiani , Wasi Bintoro Rahadi ,   Senior Lecturer,FacultyofLaw, JenderalSoedirmanUniversity, Indonesia., b Sulistyandari ,   Senior Lecturer,FacultyofLaw,JenderalSoedirmanUniversity, Indonesia.
Published: August 2023

Marriage according to the provisions of Article 1 of Law Number 1 of 1974 concerning Marriage is an inner and outer bond between a man and a woman as husband and wife with the aim of forming a happy and eternal family (household) based on God Almighty. Sometimes in a marital relationship there are protracted and irreconcilable disputes and squabbles that end in divorce. The occurrence of divorce has legal consequences, one of which is regarding the distribution of joint property. In this study, the authors conducted research on the Purwokerto Religious Court Decision Number 2354/Pdt.G/2019/PA.Pwt regarding claims for joint property on the assets of PT Mitra Software Online.The main problems and objectives in this study are to analyze the legal considerations of judges in examining, adjudicating and deciding Case Number 2354/Pdt.G/2019/PA.Pwt and analyzing the legal status of PT Mitra Software Onlines assets.Based on the results of this study, it is known that the legal considerations of judges in adjudicating, examining and deciding case Number 2354/Pdt.G/2019/PA.Pwt are based on legal facts that the objects that are claimed in the distribution of joint assets are SHGB Number: 00602 and SHGB Number: 00603 which originally belonged to Welly Bintoro and was bought by PT Software Online, so that the object became an asset owned by PT Software Online. The action of the Defendant in carrying out a sale and purchase transaction of SHGB Number: 00602 and SHGB Number: 00603 was an action for and on behalf of and representing PT Software Online because in his position as the President Director of PT Software Online. The inbreng procedure in PT so that it can be recognized as joint property in the event of a divorce is that the entry of land into the company must be carried out by way of a GMS. Inbreng can be done on movable or immovable property. Inbreng on movable objects including transactions that include non-cash assets such as land from shareholders to be used as company capital. Inbreng against immovable objects including certificates.
A STUDY ON EFFECTIVE POST-OPERATIVE CARE IN EMERGENCY/ELECTIVE LSCS PATIENTS
Authors: Babu Kamalesh , Kumar Shery Angel Raja
Published: August 2023

Aim:This study has the main objective to recognise the effectiveness of post-operative care for emergency/elective LSCS patients. Design:Cross-sectional study Methodology: Sample size:100 patients. Inclusion Criteria:Post-operative patients following Emergency/Elective LSCS. Procedure:The current study is a hospital based cross-sectional study conducted in a Tertiary Care hospital. It is a questionnaire based study. Informed consents were obtained from patients and only those who were willing to participate in the study were keenly observed during their postoperative period and the post-operative care given to them were noted.On the day of discharge patients were asked to fill the questionnaire which contains questions related to post-operative care following LSCS. Study duration:4 months. Results:The study population included 100 post operative participants following emergency or elective LSCS. On providing high skilled post operative care in a sequential manner , the patients improved symptomatically better without developing any post operative complications. It was also found that following proper post op care reduced morbidities and the duration of hospital stay. Conclusion:When proper post operative care is provided in a systematic way, the patient would improve symptomatically in a better manner. With proper post op care in hospital followed by regular follow ups we can prevent many post op complications including Surgical Site Infections , UTI , DVT , etc.
ESTIMATION OF SERUM FERRITIN LEVEL IN REGULAR BLOOD DONORS - A TERTIARY HOSPITAL BASED STUDY
Authors:   Associate Professor, Dept. of Pathology, Pt.JNM Medical College, Raipur., Joshi Chandrakala , Kumar Bhardwaj Amit ,   Associate Professor, Dept. of Pathology, Pt.JNM Medical College, Raipur., Mirdha Yashoda ,   PG Resident, Dept. of Pathology, Pt.JNM Medical College, Raipur.
Published: August 2023

Introduction: Nutritional Anemia is a worldwide problem with the highest prevalence in developing countries like India. Iron Deficiency Anemia (IDA) accounts for 8.41 lacs deaths annually worldwide. WHO/CDC in 2004 recommended Hemoglobin and Serum Ferritin level as the most sensitive markers for detection of Iron Deficiency (ID) and Iron Deficiency Anemia. Aim: To assess and compare Serum Ferritin and the Hematological Indices between control (first time donor) and regular blood donors. Materials and Methods: Donors were divided into Control (first time donors) and Case (donors who had donated atleast two times per year in the last five previous years). Following donation, blood samples from 80 donors were collected - 2 ml in EDTA tubes for CBC by using Automatic Hematolgy Analyzer machine and 4ml in plain tubes for Serum Ferritin estimation by ELISA method. Results: In our Case Control study, we noted statistically significant association between difference of mean values and frequency of donation with respect to Age and Serum Ferritin level in control and case. We also noted statistically significant association of Serum Ferritin with respect to number of lifetime donation, donation per year, Hb and MCV (pâ‰¤0.05). Conclusion: As a part of Donor Hemovigilance Program, awareness should be enhanced among blood bank professionals and regular donors about estimation of Serum Ferritin level to maintain adequate donor pool.
ULTRA HIGH-FREQUENCY ULTRASOUND - AN EMERGING IMAGING DIAGNOSTIC TECHNIQUE FOR ORAL MUCOSAL LESIONS
Authors:   Professor and HOD of Department of Oral Medicine and Radiology GDCH, Aurangabad., S. Pagare Jaishri , Kasat Vikrant ,   Associate Professor of Department of Oral Medicine and Radiology GDCH, Aurangabad., M. Ghorpade Pooja ,   First Year Postgraduate Student of Department of Oral Medicine and Radiology GDCH, Aurangabad.
Published: August 2023

In day-to-day practice, we give diagnosis of oral soft tissue lesions like oral lichen planus, pemphigus vulgaris, mucous membrane pemphigoid (MMP), leukoplakia, erythroplakia by history, clinical examination, and histological findings. But imaging modalities are never used for the diagnostic purpose of the above-mentioned lesions, though conventional ultrasonography (US) has been routinely used for the evaluation of various pathologies of maxillofacial region with frequency ranging from 3-15 MHz. Ultra-high frequency ultrasound (UHFUS) is an emerging ultrasonographic technique which uses higher frequency ranging from 30-100 MHz (mainly 70 MHz), this limits the depth of penetration upto 10mm from surface and increases the resolution of images upto 30 Î¼m. UHFUS usesintraoral ultrasonographic machine with 70 MHz probe for scanning two acquisitions i.e., B-mode and C-mode. Biomarkers used for diagnosis are growth pattern, epithelial thickness, echogenicity and vascularization. Thus, clinicians can give confirmatory diagnosis of oral mucosal lesions prior to histology. This article provides overview of imaging principles, underlying technology and in particular focuses on the emerging role of UHFUS in Oral medicine and diagnosis.
WITNESSING A PARADIGM SHIFT: ASSESSING THE ROLE OF ARTIFICIAL INTELLIGENCE IN THE DOMAIN OF EDUCATION
Authors:   Assistant Professor, Department of English and Literary Studies, Brainware University., Banerjee Aritra
Published: August 2023

This scholarly article explores the profound influence of artificial intelligence (AI) on the field of education, with a particular emphasis on the pivotal role played by ChatGPT, a sophisticated natural language model developed by OpenAI. The research comprehensively examines five key paradigms that are set to shape the trajectory of education in the years to come. These paradigms encompass the implications of AI on educational goals, instructional methods, learning materials and approaches, assessment and evaluation mechanisms, and ultimately, the overall learning outcomes. The paper contends that the integration of AI and ChatGPT in educational settings holds significant promise in enhancing students learning effectiveness, promoting wider access to educational resources, and strengthening the monitoring of educational standards. The study highlights the importance of prioritizing students creativity and critical thinking abilities in education, as these cognitive skills are essential for effectively addressing and resolving diverse challenges related to the environment, resources, economy, politics, and other aspects of future life scenarios. By harnessing AI technologies, particularly ChatGPT, novel possibilities and dynamism have been introduced into traditional pedagogical practices and methodologies, leading to a noteworthy shift towards learner-centric educational approaches. Ultimately, the authors argue that ChatGPT represents a considerable potential avenue for shaping the future of education and serving as a transformative catalyst for driving educational reforms on a broader scale.
Influence of pivot support stiffness on dynamic characteristics of vertical rotor system
Authors: Liu Qirui , Tang Changliang , Wu Tingwei , Bai Yujie
Published: August 2023

The pivot-jewel bearing pair is the only dynamic and static contact component of the flexible vertical rotor system, and its support stiffness directly affects the dynamic response of the rotor system. A non-linear dynamic model of the vertical rotor system is established, and the effect of different elastic pivot stiffnesses on the dynamic behavior of the rotor system is investigated in combination with experiments. The results show that with the increase of rotational speed, the system has the dynamic characteristics of alternating period 1 and quasi period, and when the speed reaches 550 r/s, 1/3 times low frequency whirl occurs and when the speed rises to 675 r/s, the low frequency amplitude is higher than the rotational frequency amplitude. With the increase of the elastic pivot stiffness, the amplitude of the low frequency whirl at the lower end of the rotor decreases continuously but the proportion of the “width” gradually increases. The rotational speed corresponding to the large amplitude quasi periodic motion of the rotor is delayed from 550 r/s to 650 r/s. The research results can provide a theoretical basis for the optimal design of the bearing subsystem of the vertical rotor system.
Study of vibration frequency-fatigue strength action of 6061-T6 aluminum alloy during fillet welding
Authors: Lu Jingyu , Qiu Tingqi , Chen Zhanli , Zhang Wanze , Wu Minglong , Du Chuanzhi
Published: August 2023

The research mainly focuses on the fatigue strength characteristics of 6061-T6 aluminum alloy fillet welds under different vibration frequencies. Firstly, by introducing Stress Life Curve (S-N Curve) and Probability Stress Life Curve (P-S-N Curve), the external vibration stress effects of the main load-bearing points in the stress environment of welded joints are analyzed. Subsequently, a vibration test control system is designed to analyze the relationship between vibration frequency and fatigue strength through nominal stress analysis and hot spot stress analysis. The research findings revealed that under the nominal stress analysis method, the P-S-N fitting curve showed a declining trend with an increase in fatigue life for stress variation curves with survival rates of 50 %, 95 %, and 97.7 % at vibration frequencies of 57.5 Hz, 67.5 Hz, and 77.5 Hz. At the same survival rate stress conditions, the fatigue life variation formed by resonance frequency was smaller, and the fatigue life in the resonance state was relatively lower. There is a certain correlation between vibration frequency and fatigue strength, with resonance frequency corresponding to relatively low fatigue life. This research result helps to reveal the fatigue behavior of 6061-T6 aluminum alloy fillet welds under different vibration stresses, providing a reference for the structural safety design of aluminum alloy components.
Gabor wavelet transform combined with area CNN in appearance intelligent detection of stayed cables
Authors: Li Zhiqiang
Published: August 2023

The major structure for transmitting forces in a cable-stayed bridge is the stay cable. If the stay cable system fails, the whole bridge will collapse. At present, there is no very mature technical means for the detection of bridge cables. The most common method is for workers to perform regular manual inspection and replacement of cables. Although the defect condition of the cable can be detected to a certain extent, the real-time monitoring of its health cannot be realized. Therefore, the research used the median filter, mean standardization method and Retinex algorithm to preprocess the image data. And after extracting the stay cable picture’s macroscopic characteristics using the Gabor wavelet transform, it implemented image segmentation using the OTSU approach. The obtained feature images were applied to the Faster Regional Convolution Neural Network (RCNN) recognition model to detect microscopic defects. During the research, the training efficiency of traditional Convolution Neural Network (CNN) was not high. Therefore, Faster RCNN built a cable defect recognition model. Based on this, the research built an intelligent detection model for apparent defects of stay cables based on Gabor wavelet transform and improved RCNN. Through the experimental analysis, the model built for the study has a recognition accuracy rate of 94.14 %, which can achieve dynamic bridge health monitoring and instantly identify the condition of the stay cables, and maintain the safety of the bridge.
Israel in the Middle East: A burgeoning “crescent of stability”
Authors:   Consulate General of Israel in St. Petersburg, Resnick Uri ,   The Federmann Center for the Study of Rationality Feldman building Edmond J. Safra Campus The Hebrew University of Jerusalem
Published: August 2023

The 2020 Abraham Accords normalization agreements between Israel, the United Arab Emirates, Bahrain, Morocco and Sudan have ushered in a new era in Israeli-Arab relations, setting in motion novel geopolitical dynamics both within the Middle East and radiating further afield to adjacent regions. This development marks a qualitative shift in the way that Israel’s regional integration is perceived by many within the region, with pragmatic, technology-based collaboration, both bilaterally and multilaterally, replacing the widespread acrimony which prevailed in the past. Irenic diplomacy aside, the agreements have produced tangible results in trade, tourism and collaborative technological projects focused on a host of regional development issues. Given the very strong Israeli-Greek-Cypriot “triangular” partnership, recent diplomatic achievements with Turkey and Azerbaijan and the explicit role played by India in some of the new Israeli-Arab multilateral structures, it is no exaggeration to speak of an emerging “crescent of stability” stretching from the Mediterranean, through the Caucasus, Central Asia and India, enveloping — and in many ways containing — the destabilizing influence of Iran. The research objective of the paper is to reveal Israel’s role in the Middle East region, bringing together the micro and macro levels of analysis and exploring how historical events and current developments contribute to Israel’s regional position.
Subject field of active/delayed aging research: Results of scientometric analysis and mapping
Authors:   Sociological Institute of the Russian Academy of Sciences — Branch of the Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences, Vidiasova Lyudmila А. ,   National Research University of Information Technologies, Mechanics and Optics (ITMO University), Grigoryeva Irina A. ,   Sociological Institute of the Russian Academy of Sciences — Branch of the Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences
Published: August 2023

In recent years, the global trend of population aging and its inherent features have changed the research agenda for studying older age groups. The paper is devoted to the definition of the main subject areas that are in the focus of active and delayed aging research in Russia and abroad. For the scientometric analysis, the databases Scopus and eLibrary (RSCI) were used. The study used the method of scientometric mapping using the VOSviewer program. The following terms were chosen as search terms: active aging / longevity, delayed aging, healthsaving behavior, late maturity, employment of the elderly. The analysis showed an increase in the popularity of the topic of employment in recent years, including gender-differentiating aspects. The topic of activity is more often presented in the context of “active longevity (aging)”, although at the content level the global aging process and its dynamics differ markedly from the situation of the social group of the elderly in different countries. In the topic “Activity of the elderly”, the presence of medical topics is more clearly expressed. Thematic clustering of keywords and phrases showed the multifactor nature of the studied phenomena and the need for their multidisciplinary study. It was found that articles in the social sciences are devoted to issues of social communication, adaptation, inclusion, as well as medical data and assessments of various parameters of the health of the elderly, as well as economic parameters, comparison of statistical indicators of aging, psychological and political aspects of aging.
“Voting with feet”: Russian electoral sociology on the problem of voter turnout (1989–1996)
Authors:   Herzen State Pedagogical University of Russia, Shevcov Aleksej V.
Published: August 2023

The article is devoted to the problem of turnout in elections in the USSR and Russia in the period from 1989 to 1996 in the assessment of Russian sociologists and social scientists. The theory of representative democracy in its neoliberal version narrows the acts of legitimation to the voting procedure. The experience of implementing these principles in the USSR and the Russian Federation at the end of the 20th century is quite relevant for the development of contemporary political sociology. The goal is a retrospective (historical) study of the explanatory schemes offered by Russian electoral sociologists and representatives of related disciplines on the decline in voter turnout in the 1989–1996 elections. Objectives: 1) description of specific situations, 2) analysis of the positions and arguments put forward, 3) generalization of the hypotheses and concepts proposed. Traditional methods for works of this nature were used (analysis, synthesis, heuristic, descriptive). The decline in the number of voters was constant. As in the rest of the world, it primarily affected those structures that were not perceived as significant. This led to a gradual lowering of the electoral barrier, even to its abolition. The statement about “voting with one’s feet” as a result of disappointment in the socio-economic transformations of the 1990s became a common place in the sociologists’ reasoning. The active part of the electorate, affiliated with certain political forces and organizations, reacted sensitively to mass media reports of falsifications. The general decline in voter turnout was perfectly exploited by political technologists for the benefit of their clients. The first steps of the Russian electoral sociology were not able to improve the situation in the socio-political orientation of the electorate.
Glazychev Readings as an example of a practice-oriented scientific discussion
Authors:   North-West Institute of Management — branch of the Russian Presidential Academy of National Economy and Public Administration, Beschasnaya Albina A.
Published: August 2023

The article provides an overview of the speeches at the “Glazychev Readings — 2022” in comparison with the theses of the lecture course of the master’s program “Territorial Development Management”, which was read to the audience by Vyacheslav Leonidovich Glazychev in 2010. The central topic of the conference was the discussion of the master plan “Lipovka — Voronezh”, the development of which was initiated by the mayor of the city. The distinctive features of these readings were their visiting nature in Lipetsk with direct access to the space where the presentation of projects for the transformation of the territory took place. Such a format of the scientific and practical event provided maximum practice-oriented discussions, visibility of innovations, participation in the discussion of the master plan of various stakeholders — officials, scientists, entrepreneurs, architects, builders, residents. The discussion was based around the discussion of two issues — to determine the most harmonious master plan that can satisfy the interests of different actors, and the exchange of experience in monitoring their opinions in order to find a mutual solution for territorial development. The involvement of citizens in project activities and the formation of a participating approach was the answer to the question about the tools for modernizing the management of the development of the territory. These readings became an allusion to V.L.Glazychev’s theses on the “appropriation, development and assimilation” of the territory in the process of understanding the space and prospects for its development.
“Like the Ark of Nuh”: Sayyids in the Leadership of the Huthi Movement
Authors:   Embassy of the Russian Federation to the Syrian Arab Republic, Bokov Timofey A.
Published: August 2023

The article examines the phenomenon of overrepresentation of sayyids (descendants of the Prophet Muhammad) in the Huthi movement in the 2000s. It is shown that though sayyids’ total share among the population of the northwestern Yemen was about 5 % they occupied most of the top positions in the movement and constituted about half of its military command. The trajectories of sayyid Abd al-Malik al-Huthi’s ascent to power and shaykh Abdullah al-Razzami’s descent from it are tracked down. It is demonstrated that such a prominent role of sayyids is consistent with a traditional local model of leadership, which can be traced back to the 1st millennium AD, and in which (quasi)state entities are managed either by tribesmen who have renounced their tribal identity, or by non-tribal sayyids. Other reasons of the overrepresentation of sayyids in the Movement’s leadership are considered: 1) family ties of some leaders with Hussayn al-Huthi; 2) authority and experience acquired by many of sayyids in the 1980s–1990s through active work undertaken in order to protect Zaydism from Salafi threat and state pressure; 3) reluctance of shaykhs who were affiliated with the government and/or received Saudi subsidies to support the anti-government and anti-Salafi sentiment of their fellow tribesmen, which prompted the latter to seek support from the sayyids. It is suggested that the presence of a large number of potential leaders of sayyid origin in the Huthi movement was one of the key factors that facilitated its transformation from a small group into a significant national actor in the 2000s.
Erzhenzhuan: A Reflection of Shamanistic Culture in the Folk Art of Northeast China
Authors:   Jilin Normal University, Yang Hui , Borisova Aitalina A. ,   M. K. Ammosov North-Eastern Federal University
Published: August 2023

The article deals with the actual problems of the inheritance of the ethnic traditions of shamanic culture in the modern song and storytelling dance art of the genre of comedy miniatures Erzhenzhuan of northeast China, which have preserved elements of the culture of shamanism in traditional art. In China, the term shaman first appeared in the historiography of the Southern Song Dynasty (南宋) over 800 years ago. Shamanism in a broad sense is a multicultural tradition, and at the same time integrates various ethnic cultures, including folk beliefs, traditional medicine, etc. Erzhenzhuan (二人转) is a folk song and storytelling dance art, when performers sing, tell and dance at the same time. In this case, the dance of the sorcerer in shamanism developed into a unique form of Erzhenzhuan folk art as a secularization of religious classics. Later, the sorcerer’s dance became the Balaman dance (巴拉莽式舞), the Balaman dance became the Yangge (秧歌), the Yangge became the Erzhenzhuan. The article traces the history of the development of the Erzhenzhuan style as a folk art with strong local characteristics. Erzhenzhuan was first recognized by the national literary and artistic circles of China in the fifties of the 20th century. The first Erzhenzhuan program was presented by the northeastern delegation of the People’s Republic of China. Very interesting are the original ways of performing songs, storytelling and dancing, such as Danchutou (单出头) and Lachansi (拉场戏). The transformation of the shamanic attire into the modern costume of Erzhenzhuan performers is interesting. The following describes the musical accompaniment of sacred prayers preserved from shamanic sacrificial songs. At present, Erzhenzhuan is not only flourishing in the northeast of China, but also popular with the entire Chinese people. Erzhenzhuan is now becoming more famous in the rest of China because many Erzhenzhuan performers appear on television and star in TV series. In the process of research, it is supposed to determine that in Erzhenzhuan there is an influence of the culture of shamanism on the costumes of performers, song, storytelling and dance art in a conceptually fused syncretic form.
Philosophical renovation in the 3rd century: The polemical component of Porphyry’s Vita Plotini in relation to Gregory of Neocaesaria’s Oratio Panegyrica
Authors:   Moscow Theological Academy, Trinity Lavra of St. Sergius, Soloviev Roman S.
Published: August 2023

This paper offers an analysis of similar and parallel developing projects of creating a true philosophy by the disciples and followers of Origen and Plotinus. Two texts permeated by the eulogy of the scholarch are analysed: Gregory the Wonderworker’s The Address of Thanksgiving to Origen and the Life of Plotinus by Porphyry. Gregory was a student of Origen, while Porphyry attended his school long enough to become familiar with the doctrine, teaching methods and personality of the scholarch. The author establishes the structural, thematic and lexical similarity of both texts. The text by Gregory the Wonderworker, chronologically earlier, was a pushing away point for Porphyry in creating an image of the ideal scholarch in the person of Plotinus. This is confirmed by the structural and lexical contrast in the portrayal of Plotinus in Vita Plotini and Origen in the passage preserved by Proclus (Procl. In Tim. I.63. 29–33). In particular, the negative image of Origen in Vita Plotini 13. 10–17 is echoed by the figure of Thaumasius, dissatisfied with the protracted dispute between Plotinus and Porphyry, which rarely draws the scholars’ attention. Nowhere else mentioned, Thaumasius appears as a marginal figure: either he himself was interested in general statements and wanted to hear Plotinus speaking in the manner of a set treatise (trans. Armstrong), or he wanted Plotinus to “faire une conférence suivie et propre à être écrite” (trans. Bréhier). The author hypothesises that it is not a proper name but a nickname. The author suggests that Thaumasius is not an accidental participant in a specific episode of the Neoplatonists’ school life but the philosophical rival of the Neoplatonists, theologian Origen, ironically presented in an unattractive manner. Thus, the deliberately constructed episode with Plotinus and Thaumasius is a polemical jab at Origen’s followers, who put forward a programme of philosophical renovation alternative to the Platonic, and the very depiction of Plotinus as a ‘divine man’ (θεῖος ἀνήρ) responds to the image of Origen painted by his followers. The supposed allusions in Vita Plotini 13. 5–17 testify to the openness of the Roman Neoplatonic school to the already-formed Christian version of philosophy. For this reason, Porphyry chose to portray a situation in which Plotinus showed attention and patience in interpreting difficult philosophical questions for three days. In contrast, Origen, in a similar situation, showed impatience and irritability.
“Working at full speed here”: The Department of Classical Philology at the Leningrad State University in evacuation to Saratov (1942–1944)
Authors:   S. I. Vavilov Institute for the History of Science and Technology of the Russian Academy of Sciences (St. Petersburg Branch), Skvortsov Artyom M.
Published: August 2023

The history of classical philology in the USSR during the Great Patriotic War is not yet adequately covered in science. Despite domestic and material difficulties, breakdown of communication and lack of access to literature, the pursuit of science and the training of young people continued. This article reveals how the staff of the LSU Department of Classical Philology, which was evacuated to Saratov, adapted to wartime conditions in terms of scholarly organization and research (1942–1944) based on fragmentary archival data and personal sources. With a staff of five, headed by I. M. Tronsky, the department was able to teach Latin and Ancient Literature at the Faculty of History and Philology, as well as to train a small number of “classical” students using pre-revolutionary manuals that had survived in Saratov. The research work of the department’s scholars ran counter to the general theme of the department: “Literature and War”. The titles of the papers by I. M. Tronsky, J. M. Borovsky and G. A. Stratanovsky testify to the desire to continue, as far as the book fund allowed, the themes initiated before the war, or to develop the subjects of the reception of the ancient heritage. In the beginning of 1944, under the supervision of I. M. Tronski, T. N. Chikalina presented a traditional dissertation on the syntax of the “Laws of the Twelve Tables”. The wish not to interrupt the genuinely scientific philological research and to be in the course of world science is also proved by the theme chosen for the department in 1944 — “Lucretius” — to commemorate the 2000th anniversary of the poet’s death.
Institutional Arbitration: India’s Attempt to Transpire as an International Hub of Arbitration in Southeast Asia
Authors: Pachahara Sh.
Published: August 2023

International arbitration has flourished as a private adjudicatory forum and is consistently evolving because of its versatile nature, assimilating the needs of modern arbitration users. Arbitration institutes have bent over backward for the development of international arbitration. All jurisdictions, through sporadic amendments, upgrade their curial law in alignment with the current global arbitration norms. The leading jurisdictions of Southeast Asia, specifically Singapore, Malaysia, and Hong Kong, through timely updates in their curial law and atonement of their premier arbitration institute’s policies incorporating the recent trends, continue to grow and rival each other as regional players in international arbitration. Keeping in mind India’s position in the global market, it is about time that India reserves its name among the leading arbitration hubs in Southeast Asia. Upon consideration of the trifecta of the curial law, the role of the premier arbitral institution, and the deference of the judiciary of a leading arbitration hub, the author through critical analysis, coherent reasoning, and statistical interpretation of data attempts to unveil the following questions raised. Firstly, whether India’s endeavour to strengthen and reinforce institutional arbitration in India vide the Amendment Act, 2019 would derive the desired result. Secondly, whether India’s attempt to become an international hub of arbitration that could rival Singapore, Hong Kong, and Malaysian arbitration institutes would be successful. Consequently, India’s attempt to march alongside the leading arbitral forces in Southeast Asia is like a lucid dream having the potential of manifestation.
Control and Supervisory Activities as an Institute of Administrative Law
Authors: Gavrilenko V. , Shenshin V.
Published: August 2023

This article discusses the currently relevant direction of the ongoing reform of the “regulatory guillotine.” Speciﬁcally, the article focuses on the development of new trends in the regulation of control and supervisory activities. The reasons for the reform, its goals and objectives, as well as the results achieved, are analyzed. It is concluded that the key reason for the launch of the “regulatory guillotine” is the problem of redundancy and moral obsolescence of the regulatory framework. Furthermore, the current state of control and supervision activities carried out by the public authorities of the Russian Federation is characterized, trends are analyzed and the results of the ongoing reforms are summarized. One of the main problems in the implementation of the reform is corruption. Excessive bureaucratization of control and supervisory activities is highlighted as a key factor inﬂuencing the transition to electronic document management. In connection with the identiﬁed problems, the following potential areas for future research have been identiﬁed: the introduction and legitimization of electronic document management, the reduction of corruption, the impossibility of withdrawing from the reform of some departments, the identiﬁcation of all kinds of threats and so on. In evaluating the eﬀectiveness of the activities of control and supervisory bodies in foreign countries, the emphasis has shifted away from assessing the actual number of inspections, violations detected, ﬁnes and penalties imposed, open criminal cases, the amounts of illegally spent public funds returned to the budget, etc., and to assessing the “quantity” and the “quality” of the facts revealed and the events prevented in advance, which in one way or another contained a potential threat to the security of the state and society. It was thus implied that there was a risk of not achieving socially signiﬁcant indicators (results), on the basis of which society ultimately evaluates the activities of government bodies in general and the activities of control and supervisory bodies in particular.
Mujeres y guacas cusqueñas en la Relación de las fábulas y ritos de los Incas (c. 1575), de Cristóbal de Molina
Authors: Naranjo Liliana
Published: August 2023

Este artículo explora la representación de las mujeres guacas en las ceremonias sagradas de iniciación en el incario. Es una investigación histórica que utiliza como marco referencial La relación de las fábulas y ritos de los Incas, de Cristóbal de Molina el Cusqueño (c. 1575). El análisis destaca la importancia de las fuentes de Molina, en particular en los rezos y los nombres dados a los númenes femeninos Pachamama y Pacsamama. Además, reflexiona sobre el modo como Molina muestra a las guacas mujeres como agentes sagrados con un papel activo y mediador entre los ámbitos doméstico y estatal.
The blood-prostate barrier: an obstacle to drug delivery into the prostate
Authors: Mou Yixuan , Cao Min , Zhang Dahong
Published: August 2023

The blood-prostate barrier (BPB), a non-static physical barrier, stands as an obstacle between
the prostate stroma and the lumen of the prostate gland tube. The barrier has the ability to dynamically
regulate and strictly control the mass exchange between the blood and the prostate, thereby limiting drug
penetration into the prostate. The basement membrane, fibrous stromal layer, capillary endothelial cell,
prostatic ductal epithelial cell, lipid layer, etc., have been confirmed to be involved in the composition of
the barrier structure and altered membrane permeability mainly by regulating the size of paracellular ion
pores. Various studies have been conducted to improve the efficiency of drug therapy for prostate diseases by changing the administration approaches, improving barrier permeability and increasing drug
penetration. To gain a full understanding of BPB, the composition of BPB, the methodology for evaluating the permeability of BPB and alterations in barrier function under pathological conditions are summarized in this review. To find a shortcut for drug delivery across BPB, the biodistribution of drugs in the
prostate and different methods of improving drug penetration across BPB are outlined. This review offers an applied perspective on recent advances in drug delivery across BPB.
Insight View on the Pharmacological Potential and Bio-active Components of Ginger
Authors: Sethiya Ayushi , Teli Pankaj , Agarwal Dinesh Kumar , Agarwal Shikha
Published: August 2023

:

Ginger is a very renowned herbaceous plant that has been extensively used as a flavoring agent and herbal medicine for decades. It possesses a plethora of pharmacological properties, including anti-inflammatory, anti-oxidant, antimicrobial, anti-diabetic, anti-tumor, anti-viral, anti-Alzheimer, analgesic, cardio-vascular, etc. In this review, a comprehensive summary of the pharmacological potentials of ginger and its bioactive components is described. Their mechanisms of action against different diseases and targets are also discussed, which can lay the foundation for their medical applications.
Revealing ANXA6 as a Novel Autophagy-related Target for Pre-eclampsia
Based on the Machine Learning
Authors: Zhu Baoping , Geng Huizhen , Yang Fan , Wu Yanxin , Cao Tiefeng , Wang Dongyu , Wang Zilian
Published: August 2023

Background:

Preeclampsia (PE) is a severe pregnancy complication associated with autophagy.

Objective:

This research sought to uncover autophagy-related genes in pre-eclampsia through bioinformatics and machine learning.

Methods:

GSE75010 from the GEO series was subjected to WGCNA to identify key modular genes in
PE. Autophagy genes retrieved from the THANATOS overlapped with the modular genes to yield PErelated autophagy genes. Furthermore, the crucial step involved the utilization of two machine learning
algorithms (LASSO and SVM-RFE) for dimensionality reduction. The candidate gene was further verified by quantitative reverse transcription polymerase chain reaction, western blot, and immunohistochemistry. Preliminary experiments were conducted on HTR-8/SVneo cell lines to explore the role of
candidate genes in autophagy regulation.

Results:

WGCNA identified 291 genes from 5 hubs, and after overlapping with 1087 autophagy-related
genes obtained from THANATOS, 42 PE-related ARGs were identified. ANXA6 was recognized as a
potential target through SVM-RFE and LASSO analyses. The mRNA and protein expression of
ANXA6 were verified in placenta samples. In HTR8/SVneo cells, modulating ANXA6 expression altered autophagy levels. Knocking down ANXA6 resulted in an anti-autophagy effect, which was reversed by treatment with CAL101, an inhibitor of PI3K, Akt, and mTOR.

Conclusion:

We observed that ANXA6 may serve as a possible PE action target and that autophagy
may be crucial to the pathogenesis of PE.
A Review: Ophiocordycep Sinensis (Berk.) as a Traditional Tibetan Medicine and its Potential in the Treatment of Various Human Ailments
Authors: Kom Yangchen Dolma , Karthiyayini R.
Published: August 2023

Nature’s never-ending gift, which counts as one of the most valuable medicines in the
entire world, the Ophiocordyceps sinensis, also known as caterpillar fungus, is a traditional Chinese
medicine found in Tibetan plateaus. During the season of spring, many shepherd search for this caterpillar
fungus as its value in the market is very high. Moreover, due to the effects of climatic
change on its population and increasing demand, O. sinensis is now an endangered species. It can
treat almost many diseases, such as cardiovascular disease, respiratory diseases, immune dysfunction
etc. The chemical composition of this fungus includes amino acids, glutamic acid, polyamines,
cordycepic acid, saccharides, sterols, nucleotides, sugar derivatives, fatty acids, vitamins, and oleic
acid.
Use of Artificial Intelligence in Assessing the Livestock Management
Authors: Hamid Muhammad , Mushtaq Nadia , Ahmad Hafiz Ishfaq , Haider Ghulam
Published: August 2023

In the livestock sector, artificial intelligence is crucial. The livestock
business needs to make improvements to artificial intelligence right away. With the aid
of artificial intelligence, livestock farms will be able to make the processes automatic
with reduced major costs and an improvement in the quality of livestock products.
Artificial intelligence assists livestock farms in gathering data and performing analysis
accurately according to consumer behaviour prediction, such as buying patterns,
leading trends, etc. The livestock business will undergo significant upheaval thanks to
artificial intelligence. Many dairy farms and local farmers utilize animal feed without
considering how it will affect the milk and the animals. AI use will undoubtedly
significantly impact the quality of the forage and the animals' way of life as AI is
increasingly widely used and accessible. Most dairy sector activities will be automated,
and data about past farm operations will be generated. Farmers are now turning to
smarter approaches to help regulate the right use of land, water, and energy needed to
feed the world's population and alleviate the global food problem in response to the
expanding population. By utilizing machinery and monitoring systems, AI technology
has changed farming and cattle-related businesses.
Role of Recombinant Vaccine in Livestock
Authors: Ali Ahmad , Ijaz Muhammad , Anas Naeem Muhammad , Shakeel Ramsha , Ghaffar Awais , Razzaq Khan Yasir , Zeeshan Zafar Muhammad , Hussain Kashif , Shahid Muhammad , Naseer Omer , Hamza Rabbani Ameer , Abdul Qudus Mahar
Published: August 2023

A lot of diseases affect animals which need treatment. Antibiotics and other
drugs have been widely used in the treatment. Drug residues in milk and meat are the
main issues and pose health risks to humans. A vaccine is the only solution to keep
animal products safer from drug residues. Modern veterinary vaccine history started in
the 19th century when Edward Jenner used antigens from cowpox pustules. A vaccine
is a weakened organism or part of an organism that is given to animals to produce
immunity by the body. Soon after the development of vaccines, safety issue arises.
Especially live attenuated vaccine was a matter of concern as it may revert to cause
disease. Nowadays, most of the livestock vaccines are live attenuated or killed.
Vaccines have been developing against bacteria, viruses and parasites also. Animal-origin products are also contaminated with parasite infection and are a source of
infection to other animals and humans. Parasites usually stay in the gastrointestinal
tract of animals, and oocytes are disseminated through feces into the environment,
which are transmitted to other animals. Vaccines are cost-effective methods to prevent
diseases in animals and humans. It not only enhances animal meat and milk production
but also saves humans from zoonotic diseases. Without vaccines against major animal diseases, it will not be possible to feed 7 billion people with proteins. Zoonotic
diseases, such as brucellosis and Leptospirosis, will be more prevalent in the world
without the vaccination of animals. Rinderpest is almost eradicated from the globe and
will be the second disease after smallpox which is diminished through proper
vaccination and surveillance.