bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Surface Water Quality by using Multivariate Statistical Techniques of Various Lakes of Kancheepuram District in Tamil Nadu, India.
Authors: Kuppusamy M. , Sridhar T.
Published: June 2023

Multivariate statistical methods such as Principal Component Analysis/Factor analysis (PCA/FA), and Cluster Analysis (CA) were used to characterize spatial and temporal variations and to find out the pollution source of 11 lakes of the Kancheepuram district, a northeast district of Tamilnadu in India. Sampling events were conducted during the northeast monsoon (Dec 2015 & 2016) and Pre-monsoon (Oct 2016). The 20 physicochemical water quality parameters were used to analyze the collected water samples. In PCA, four components were demonstrated up to 73.12% of the total variance in the data set. It clarifies that variations in water quality parameters concentration are mainly identified with agricultural, industrial, domestic wastes, and natural factors. The CA showed the formation of three clusters based on the water quality variation at different locations. From the CA data, sampling sites were classified into high, moderate, and least polluted. Among these sites, Kolavai, Nattapettai and Uthiramerur were highly polluted because of rapid urbanization and industrialization. Therefore, these areas need some effective measures to enhance the quality of water.
"Le Phénomène de la Traduction entre Tradition et Evolution"
Authors:   Alexandru Ioan Cuza University of Iaşi, Ilie Alexandra
Published: June 2023

À nos jours, les discutions sur la traduction ont dépassé, depuis longtemps déjà, les barrières imposées par les premiers théoriciens de la Traductologie. Si avant on soutenait la thèse contre la traduction, en apportant des arguments sur ses impossibilités, aujourd’hui, on considère que la traduction peut être effectuée même par un moteur automatique. Dans cet article, nous nous proposons de présenter ce domaine si controversé, par une perspective évolutive, le point visé étant de montrer les plus importantes étapes dans son évolution jusqu’à nos jours. Nous allons également mettre en évidence les plus notables découvertes dans l’histoire de la Traduction automatique.
"The Framing of Music Therapy in Scientific Articles Published in “Dementia” in 2008-2017"
Authors:   University of Bergen, Kapranov Oleksandr
Published: June 2023

The present article involves a diachronic qualitative study of how music therapy is framed in scientific articles published in “Dementia”, an international peer reviewed journal regarded as a major forum for social research in dementia. The aim of the study is to elucidate how the framing of dementia is represented diachronically in “Dementia” over the period of ten years, from 2008 until 2017. The corpus of the study is comprised of 13 scientific articles published in “Dementia” in 2008-2017. The results of the qualitative framing analysis indicate that music therapy is framed in “Dementia” by means of the following frames: “Aggression”, “Agitation”, “Caregiver”, “Nonpharmacological Intervention”, “Quality of Life”, and “Social Ecology”. These frames are further analysed and discussed in the article.
Mobile Assisted Language Learning: Advantages and Use among Different Age Groups
Authors:   University of Graz, Radin Jasmina
Published: June 2023

Mobile assisted language learning (MALL) facilitates situated, authentic, context aware, contingent and personalized learning. These and more advantages supported by teaching methodology theories are explained and related to suggestions for practical uses of MALL among different age groups (young learners, teenagers and students, and digital immigrants). Criteria for selection of appropriate mobile technologies are also suggested.
Development of artistic expression in deaf and hard-of-hearing preschool children
Authors: Kovačević Tamara , Đoković Sanja
Published: June 2023

This paper discusses the development and specifics of artistic expression in deaf and hard-of-hearing preschool children. We analyzed the significance of the stages of artistic development and the therapeutic effect of artistic expression. A drawing made by a deaf or hard-of-hearing child provides the opportunity to assess their cognitive, social, emotional, and physical development, the development of perception, a sense of beauty, and creativity. Through expressive and aesthetic development, children expand their knowledge and skills in nonverbal, visual, auditory, sensory, and verbal experiences. The artistic expression of deaf and hard-of-hearing children does not lag behind that of a hearing child. Visual representations of children with hearing impairment are much more realistic than those of hearing children. Visual perception of deaf and hard-of-hearing children contains many details related to physiognomy, movement, facial expression, body posture, and color. Children use art to communicate with themselves and the environment. In deaf and hard-of-hearing preschool children, it is necessary to develop all functions of nonverbal and verbal communication through artistic expression.
Organizational effects of healthcare institutions entering the healthcare tourism system
Authors: Milutinović Olivera , Anđelić Slavica
Published: June 2023

The importance of the effect of the organization of health institutions on the system of health tourism is important not only from the point of view of scientific management theory, but, above all, in order to make strategically important decisions for the further functioning and development of the new, reformed health care system in Serbia. In the new organizational environment, healthcare workers will have a new and more complex role. The organization of health institutions and the role of employees in health care will be directed towards the users of health services with constant work on their own education, as service providers, as well as the education and information of users. Healthcare has characteristics that distinguish it from other fields. Specific characteristics include knowledge of health services and their value. Effective organization of health institutions in the health tourism system is essential for creating a high impact health system.
Chestnut weevil Curculio elephas (Gyll.) (Coleoptera: Curculionidae) in Una-Sana canton (B&H)
Authors: Delalić Zemira
Published: June 2023

The Una-Sana Canton (the northwest part of Bosnia and Herzegovina) abounds in large forest areas, where the self-sown sweet chestnuts Castanea sativa Mill. grow. However, the plant has been endangered due to the negative effects of disease-causing agents, harmful insects, and human factors (uncontrolled forest logging). Moreover, the chestnut weevil Curculio elephas causes significant damage to the local chestnut fruit. This study aims to analyze the emergence of the pest and the damage which it produces in the forest areas of the northwestern Bosnia and Herzegovina, precisely in Una-Sana Canton. The presence of the chestnut weevil has been examined on samples taken from 15 locations in chestnut forest in the municipalities of Cazin, Velika Kladuša and Bužim. In order to research this phenomenon more precisely, each fruit has been cut, the larvae have been separated from it and damage in the inner part of the fruit has been observed. The number of larvae has been noted per a sample. With respect to each sample, the mass of healthy and damaged part of the fruit has been measured. The number of larvae ranges from 5 to 15 per sample. The percentage of damaged fruit parts ranges from 4,2% to 13,6%. The reason for the increased presence of the chestnut weevil in the analyzed chestnut forest is in addition to the beneficial chemical composition of the fruit and the late detection of the presence of insect existing in severely large populations. The use of chemical preparations (pesticides) as a solution to this issue is ecologically unacceptable, especially in a larger area. It is mandatory to manually collect all the fruit that fells of the chestnut trees prematurely and, moreover, to stop the further development of the larvae. Considerable results can also be achieved by separating individual chestnut stands and changing the purpose of its use, as well as combining the method with the limited use of pesticides.
Economicly important viruses of pepper identified in the area of the Republic of Srpska
Authors: Babić Gordana , Trkulja Vojislav , Budakov Dragana , Iličić Renata , Mališević Rade , Bagi Ferenc
Published: June 2023

Pepper is attacked by numerous plant diseases caused by phytopathogenic fungi, bacteria and viruses, interfering normal growth and development, reducing the yield and quality of fruits. Among the mentioned groups of pathogens, phytopathogenic viruses reduce the yield of pepper every year. The most common and economically important, identified in Republic of Srpska, are: Cucumber mosaic virus (CMV), Alfalfa mosaic virus (AMV), Tobacco mosaic virus (TMV) and Tomato spotted wilt virus (TSWV). The paper describes the distribution, economic importance, hosts, transmission, symptoms, as well as control measures for mentioned viruses.
Forecast of water consumption in Serbia: ARIMA modeling
Authors: Gazdić Danilo , Nikolić Srboljub
Published: June 2023

Water is a symbol of life. Along with air and food, water is a basic existential need. These facts begin to act more strongly on people's opinion and behavior only when he faced with water supply problems. The question is, how to produce more food in these times of growing need for it, while water resources are limited. The Republic of Serbia has a very significant water capacity. Estimation shows that renewable freshwater resources in Serbia are round 55877.93 million of m 3 /per year (Eurostat, 2020). However, water consumption in Serbia is constantly growing, while population is slightly decreasing, which arise the need for time series analysis of water consumption as a tool for future forecast of water consumption.
Data -driven reliability and availability of electronic equipment
Authors: Pokorni Slavko
Published: June 2023

Introduction/purpose Reliability and availability are important especially for military, medical, and other professional equipment. Reliability and availability management and/or prognostic reliability calculations have always been data driven. This article focuses on the analysis of the data impact on reliability and availability. Methods: This research is based mostly on the articles published by the author of this work as well as on some other papers. Results: This paper results in a discussion on the definition of the data-driven concept, preceded by brief definitions of reliability and availability, and followed by the analysis of the main impacts of uncertain data on prognostic reliability calculations as well as by reliability and availability of data used in reliability calculations. Conclusions: Reliability and availability are still very important. Reliability and availability have always been data driven while valid and relevant data have always been the main problem. Without good data, prognostic reliability is useless in spite of a good reliability model.
SOCIAL MEDIA AND ELECTORAL VIOLENCE IN NIGERIA: SUSTAINABLE DEVELOPMENT GOAL 16, A PANACEA?
Authors:   Adeniran Ogunsanya College of Education, Akinyetun Tope Shola , Odeyemi Dare Deji ,   Adeniran Ogunsanya College of Education, Alausa Jamiu Abiodun ,   Adeniran Ogunsanya College of Education
Published: June 2023

Social media has changed the way people interact, transact, share information and participate in political activities. Of course, the electoral process in Nigeria, as is in other parts of the world, has been remarkably impacted by the proliferation of social media. However, despite the enormous advantages it holds, social media has also proven to be a tool for inciting electoral violence through disinformation, misinformation, hate speech, and propaganda. Indeed, it is imperative to adopt an alternative framework in addressing the grave danger inherent in social media and the fomentation of electoral violence in Nigeria. It is on this premise that Sustainable Development Goal (SDG) 16 which seeks to promote peaceful and inclusive societies for sustainable development, provide access to justice for all and build effective, accountable, and inclusive institutions at all levels is recommended. The paper adopts a descriptive approach and argues that peace is a requisite for health, well-being, and sustainable development while strong institutions are pivotal to the attainment of peace. Therefore, the promotion of peace, justice, inclusion, and strong institutions must be treated as society’s latest tall order. Consequently, the paper recommends the establishment of an Electoral Peace Commission, Justice Commission, strengthening of electoral institutions, and the censorship of inciting words on social media platforms as plausible solutions to electoral violence as caused by social media in Nigeria.
The Effect of Organizational Commitment and Personal Costs on Intention to do Whistleblowing
Authors: Pratiwi Yunita , Rahayu Sri , Yetti Susfa
Published: June 2023

This research was conducted to examine the causes or factors that influence a person's intention to do whistleblowing. This study aims to determine whether Organizational Commitment and Personal Cost affect the intention to do whistleblowing at the Jambi Province Education Office. The data used is primary data obtained through questionnaires distributed to employees who work at the Jambi Province Education Office and the research sample is 268 employees who work at the Jambi Provincial Education Office with a sampling technique using saturated sampling method. Methods of data analysis using multiple linear regression analysis using the SPSS program.
Evaluation of Sorghum Genotypes for Striga (S. hermonthica) Tolerance
Authors: Mutezo Wilbert , Sedibe Moosa M.
Published: June 2023

Striga infestation and transmission, and the adverse impact of Striga on crop yield can essentially be diminished through selection of resistant genotypes. The study was carried out to screen sorghum genotypes for Striga hermonthica (Striga) tolerance based on their physiological responses to the parasitic effects of this weed. Seventy-five grain sorghum [Sorghum bicolor (L.) Moench] genotypes were subjected to three levels (0 mg, 2.5 mg and 5 mg/pot) of Striga at Rattary Arnold Research Institute in Zimbabwe. One way analysis of variance results show that there were significant difference among genotypes on plant height, chlorophyll content, leaf number, field weight, grain weight, panicle height for Striga*genotype interaction for all the 75 sorghum genotypes (P<0.001). The correlation matrix show that fresh panicle weight and grain dry weight showed a very high correlation (0.948) at P<0.05. Panicle height and fresh panicle weight are highly correlated (0.736) at P<0.05. Similarly, panicle height and grain dry weight were also highly correlated (0.718) at P<0.05. The heatmap analysis shows that 45%, 31% and 24% of the cultivars exhibited high, medium and low plant heights respectively. Chlorophyll content showed that 80% and 20% of the cultivars showed medium and low amounts, respectively. All the 75 genotypes recorded low leaf numbers when compared to the control experiment. It was observed that 25%, 63% and 12% for the genotypes produced high, medium and low fresh panicle weight and dry grain weight values respectively. The panicle size for most (87%) of the genotypes was medium while 13% of the cultivars showed very small sized. Principle component analysis using the scree plot Eigen values shows that the first factor contributes 58% of the cumulative variation. Two principal axes (F1 and F2) were selected, which explained about 74.45% of the total variation. Neighbour-joining hierarchical clustering analysis led to the formation of five groups for Striga*genotype interaction. It can be concluded that Striga hermonthica affects negatively crop morpho-physiologaical aspects such as plant height, chlorophyll content and leaf number as well as yield determining components such as field weight, panicle height which ultimately reduce the yield of sorghum. The existence of high variability in the response to Striga hermonthica infestation in the 75 sorghum genotypes gives the possibility to breeding interventions to improve tolerance to this parasitic weed.
Agroeconomic Value of Some Lathyrus and Vicia Species in the Republic of Moldova
Authors: Ţîţei Victor , Cozari Serghei
Published: June 2023

The efficient use of the biological potential of the leguminous plants that are adapted to the local climatic conditions becomes more and more relevant. The local ecotype of the species Lathyrus sativus, Lathyrus sylvestris, Lathyrus tuberosus, Vicia hirsuta, Vicia sativa, Vicia tenuifolia maintained in monoculture on experimental land in the NBGI Chişinău, served as objects of study. We found that the dry matter of the studied whole plants contained 169-257 g/kg CP, 96-125 g/kg ash, 219-346 g/kg CF, 244-371 g/kg ADF, 427-576 g/kg NDF, 34-58 g/kg ADL, 210-313 g/kg Cel, 183-205 g/kg HC, 64-150 g/kg TSS, with 59.3-69.4% DMD, RFV = 93-151, 11.87-13.55 MJ/kg DE, 9.75-11.13 MJ/kg ME, 5.77-7.22 MJ/kg NEl. The prepared hay contained 153-264 g/kg CP, 91-135 g/kg ash, 244-356 g/kg CF, 294-393 g/kg ADF, 475-606 g/kg NDF, 36-65 g/kg ADL, 258-329 g/kg Cel, 191-214 g/kg HC, 6-99 g/kg TSS, with 59.2-66.0% DMD, RFV = 90-129, 11.57-12.95 MJ/kg DE, 9.50-11.09 MJ/kg ME, 5.51-7.10 MJ/kg NEl. The haylage is characterized by pleasant smell and color, pH = 4.40-4.95, 4.7-6.1 g/kg acetic acid, 27.9-38.0 g/kg lactic acid, butyric acid was not detected, 159-180 g/kg CP, 105-125 g/kg ash, 296-343 g/kg CF, 316-360 g/kg ADF, 460-579 g/kg NDF, 51-55 g/kg ADL, 263-309 g/kg Cel, 142-219 g/kg HC, 43-106 g/kg TSS, 60.9-64.1% DMD, RFV = 98-129, 12.03-12.61 MJ/kg DE, 9.88-10.35 MJ/kg ME, 5.89-6.37 MJ/kg NEl. The harvested fresh mass and the haylage prepared from the studied species can be used as substrates in biogas production via anaerobic digestion for renewable energy production, with carbon nitrogen (C/N) ratios 12-20. The biochemical methane potential reached 320-378 litre/kg organic matter. The investigated leguminous species are an important forage source for livestock, many birds, bees and entomophagous insects, and they are excellent plants for erosion control and for reseeding and increasing the economic value of permanent and temporary grasslands. The harvested biomass can be used as alternative fodder for farm animals or as substrates in biogas generators for the production of renewable energy.
Asymmetric Short-Run and Long-Run Impact of Economic Globalization on Crop Production in Turkiye
Authors: Koyuncu Cuneyt , Unver Mustafa , Kaya Muhammed Veysel
Published: June 2023

This study explores short-run and long-run relationship between economic globalization and crop production in Turkiye by utilizing linear and nonlinear ARDL models for two distinct indicators of crop production. Based on linear and nonlinear ARDL bound tests, the relevant variables are co-integrated and hence they move together in the long run. Economic globalization and crop production possess statistically significant positive association in the long run in linear ARDL models. On the other hand, short-run and longrun symmetry test results disclose that the relationship of economic globalization and crop production in the short-run and long-run is asymmetric. According to the estimation findings, positive and negative changes in economic globalization augment crop production. Meanwhile several tests were conducted to check the statistical validity and robustness of our findings. The results of those diagnostic tests show that neither linear ARDL models nor nonlinear ARDL models incorporate problems in the sense of non-normality, autocorrelation, heteroskedasticity, model misspecification, and parameter instability.
REGULAÇÃO DO TRATAMENTO DOS DADOS PNR PELA ANAC, SOB A PERSPECTIVA DA LGPD
Authors: Eroud Aicha de Andrade Quintero , Davies Erika Patricia de Souza , Masseno Manuel David
Published: June 2023

A pesquisa em questão busca analisar as alterações legislativas, no que tange ao tratamento dos dados PNR – Passenger Name Record / Registro de Número de Passageiro pela ANAC, com base na Lei Geral de Proteção de Dados Pessoais – LGPD. Almeja-se compreender os efeitos irradiados pela LGPD sobre os dados PNR, com a finalidade de verificar a efetividade da proteção dos dados em estudo. Considerando o alto fluxo de viajantes nacionais e estrangeiros, no Brasil, e, consequentemente, o aumento no recolhimento dos dados PNR, há a necessidade de conferir maior proteção a estes, já que, também, possuem valor econômico e invocam questões de privacidade. O método utilizado para compor o presente trabalho é o dedutivo, com base em pesquisas bibliográficas e aportes documentais.
Evaluación de la calidad de cuidados de enfermería en una institución privada en el periodo agosto/ septiembre de 2021
Authors: Sandivares Flavio , Ibarra Rosana , Vallejos Carolina
Published: June 2023

Es de importancia analizar desde el punto de vista de gestión de  calidad y seguridad del paciente donde los cuidados enfermeros se consideran un elemento unificador y exigen a los profesionales a trabajar con un método evaluando sistemáticamente los cuidados y posicionan a los profesionales enfermeros como parte importante del equipo de salud. Esta calidad de servicio puede ser  estimada a través de un indicador de calidad que sirve para medir también el grado de satisfacción del cliente. Teniendo como objetivo evaluar el proceso de calidad de las prácticas de enfermería que aportan a la seguridad de los pacientes. Es de relevancia entender que la calidad y la seguridad del paciente, deben ser enfrentadas como un proceso continuo, que permita mediciones que traduzcan en mejoras significativas y que puedan llevar a programas de intervenciones.Se revisaron conceptos como calidad del cuidado, gestión del cuidado, indicadores de calidad para medir el grado de satisfacción del profesional como del cliente.
El control de los objetores de conciencia tras la nueva ley de la eutanasia
Authors: Valcárcel García Macarena
Published: June 2023

With the intention of analyzing the controls on the objects of conscience in the health field, an approximation to the concept of this right to avoid a tender activity that the law requires for reasons of conscience is carried out in the first place, in order to subsequently carry out a review with due depth of the constitutional jurisprudence that has been building, with different course changes in its interpretation, since 1982. The development of the necessary regulations that have supported and protected the exercise of conscientious objection, in the different areas where this has a place in Spain, occupies the next part of the text until reaching the regulations in the specific field of health conscientious objection, making an analysis of its content and its results, especially and due to the existence of sufficient data on the objection to voluntary terminations of pregnancy. Finally, the analysis of the registry of objects established by the Organic Law of Euthanasia, whose development has been transferred to the Autonomous Communities, and the proposal of the possibility of a substitute benefit to the objects of sanitary conscience finalize this article.

Con la intención de analizar los controles sobre los objetores de conciencia en el ámbito sanitario, se realiza en primer lugar una aproximación al concepto de este derecho para evitar una lícita actividad, por motivos de conciencia, a la que la ley obliga a realizar determinas prácticas. Posteriormente se llevará a cabo una revisión con la debida profundidad de la jurisprudencia constitucional que ha venido construyéndose, con distintos cambios de rumbo en su interpretación, desde 1982. El desarrollo de la necesaria normativa que ha amparado y ampara el ejercicio de la objeción de conciencia, en los distintos ámbitos donde esta tiene cabida en España, ocupa siguiente parte del texto hasta llegar a las regulaciones en el ámbito concreto de la objeción de conciencia sanitaria haciendo un análisis de su contenido y de sus resultados, en especial y por la existencia de datos suficientes sobre la objeción a las interrupciones voluntarias del embarazo. Finalmente, el análisis del registro de objetores establecido por la Ley Orgánica de la Eutanasia, cuyo desarrollo se ha trasladado a las Comunidades Autónomas, y la propuesta de la posibilidad de una prestación sustitutoria a los objetores de conciencia sanitarios finalizan este artículo.
Remapping in a recurrent neural network model of navigation and context inference
Authors: Low Isabel I.C. , Giocomo Lisa M. , Williams Alex H.
Published: June 2023

Neurons in navigational brain regions provide information about position, orientation, and speed relative to environmental landmarks. These cells also change their firing patterns (“remap”) in response to changing contextual factors such as environmental cues, task conditions, and behavioral state, which influence neural activity throughout the brain. How can navigational circuits preserve their local computations while responding to global context changes? To investigate this question, we trained recurrent neural network models to track position in simple environments while at the same time reporting transiently-cued context changes. We show that these combined task constraints (navigation and context inference) produce activity patterns that are qualitatively similar to population-wide remapping in the entorhinal cortex, a navigational brain region. Furthermore, the models identify a solution that generalizes to more complex navigation and inference tasks. We thus provide a simple, general, and experimentally-grounded model of remapping as one neural circuit performing both navigation and context inference.
Analysis of Quality Cycles on Performance of Tea Processing Firms in Kenya
Authors: Wanjobi George Muturi , Yatich Henry , Ndolo Jackson
Published: June 2023

Aim of Study: The aim of the study was to assess how quality cycles impact the performance of tea processing companies in Kenya. The research was guided by Deming's quality improvement theory. Pragmatism research philosophy was employed in this research.

Study Design: Further, explanatory research design was deemed appropriate for the research.

Methodology: The study population under consideration was 66 operations managers of all the tea producing companies. A census of all the 66 operations managers was conducted. Utilizing structured questionnaires, both quantitative and qualitative data was gathered for analysis. Data analysis was undertaken utilizing SPSS Version 23.0.

Results: The findings revealed that quality cycles had positive and significant relationship with performance of tea processing firms in Kenya where (β =.335) and p=.011). The study concludes that quality cycles are critically important in the production of tea. Tea processing firms need to cultivate culture of team work among their workers by emphasizing virtues of unity and togetherness. The study recommends for periodic diagnostic and maintenance of firm machines and equipment through well trained firm personnel. Thus, training of personnel on the maintenance of tea production equipment is essentially important in ensuring that costs arising from breakdowns are minimized. Organizational dynamic capability moderates the relationship between Kaizen Systems and performance of tea processing firms. Also, tea processing firms should invest in research and development, training, networking capability and innovation since it affects performance positively.
Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Bilastine and Montelukast in Tablet Dosage Form
Authors: Vallakeerthi Narmada , Swetha Rachala , Tejaswi T. , Nath A. Ravinder , Bhavyasri K. , Reddy N. Naresh , Reddy P. Muralidhar
Published: June 2023

Place of Study: Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana.

Aim: The present study is describing about the development of a new RP-HPLC method for the simultaneous estimation of Bilastine and Montelukast in Active Pharmaceutical Ingredient (AI) and commercial formulations.

Methodology: In the present investigation, an Inertsil ODS C18 column dimensions of 250 mm length x 4.6 Internal diameter x 5-micron particle size has been chosen. Phosphate buffer and acetonitrile were opted as isocratic mobile phase at a ratio of 30:70, with a flow rate of 1 ml/min. The pH of the developed buffer was maintained at 4.6 and the temperature was set at room temperature. The wavelength of Bilastine and Montelukast was observed at 260 nm. For both Bilastine and Montelukast the retention time has been observed at 2.319 and 4.299 minute correspondingly. The percentage purity of both the drugs was found to be 100.6 % and 100.3 % correspondingly. The developed method satisfied all the system suitability parameters for Bilastine and Montelukast and the observed values for theoretical plates were found to be 1.3 and 1.4 respectively, tailing factor were found to be 5117.5 and 3877.8 respectively with a resolution of 9.0.

Results: Finally, the method was validated by parameters such as precision, accuracy, robustness and ruggedness. The linearity and range were from 1-5µg and 100-500 µg concentrations series, the correlation coefficient for both the drugs was noted to be 0.999 while the mean percentage recovery was observed at 100.1 percent & 100.4 percent. The % RSD for repeatability was found to be 0.31 and 0.38. The % RSD of intermediate precision was found to be 0.12 & 0.15 correspondingly. The LOD values were found as 2.94, 3.03 and for the LOQ values were found as 9.87, 10.1.

Conclusion: The developed method which was validated was observed to be novel, accurate, simple, robust, precise, repeatable for the present study with a suitable RP-HPLC technique to concurrently determine Bilastine and Montelukast present in the commercial formulation. This developed method is useful on daily basis due to their accurate results, reproducibility, robustness for the estimation of samples in routine quality control departments.
Evaluation of Mulching Methods and Legume Intercropping on Weed Control Efficiency and Agronomic Traits of Pearl Millet (Pennisetum glaucum)
Authors: Sharon X. Catherine , Manuel R. Isaac , Sharmili K. , Kumar Dinesh
Published: June 2023

Aim: To evaluate the weed control efficiencies of different mulching practices and legume intercropping in transplanted pearl millet.

Study Design: Randomized Complete Block Design (RBD).

Place and Duration of Study: The field trial was conducted during the Rabi season of 2022 at the school of agricultural sciences in Karunya Institute of technology and sciences, Coimbatore, Tamil Nadu.

Methodology: The field trial consists of 8 treatments viz., T1 - PE of Atrazine 0.5kg/ ha +1 Hand Weeding at 30 DAT, T2 - Two Hand Weeding at 15 and 30 DAT, T3 - Paddy straw mulching at 5t/ ha 3 DAT, T4 - Black polythene mulching at 3 DAT, T5 - Black silver polythene mulching at 3 DAT, T6 - Intercropping of pulses (cowpea) (1:1), T7 - Intercropping of pulses (cowpea) (1:1) + PE Pendimethalin 0.75 kg/ ha, T8 - Un weeded check.

Results: Results of the experiment proves that the intercropping of cowpea in pearl millet along with the pre-emergence application of pendimethalin proves to be beneficial and advantageous in terms of returns per rupee invested for profitable crop production, rather than going for polythene mulches. Hence adoption of legume intercropping in pearl millet, along with the usage of mild herbicides like pendimethalin, will be an economically viable and environmentally sustainable weed management practice for improving the yield of pearl millet.
Nowhere Else to Go—Solitary Confinement as Mental Health Care
Authors: Morris Nathaniel P. , Izenberg Jacob M.
Published: June 2023

This Viewpoint examines the clinical, ethical, and legal concerns of the use of solitary confinement to manage acute psychiatric distress among incarcerated people.
Delivery accuracy of VMAT on two beam‐matched linacs provided by accelerated go live service
Authors: Tsuneda Masato , Abe Kota , Fujita Yukio , Morimoto Ryo , Hashimoto Takuma , Abe Yukinao , Uno Takashi
Published: June 2023

Introduction

Dosimetric accuracy is critical when a patient treated with volumetric modulated arc therapy (VMAT) is transferred to another beam‐matched linac. To evaluate the performance of Accelerated Go Live (AGL) service, the measured beam characteristics and patient specific quality assurance (QA) results between two AGL‐matched linacs were compared.

Materials and Methods

Two VersaHD linacs were installed using the AGL service. After the installation, the beam data such as percentage depth dose (PDD), lateral profiles and output factors for all photon beams were measured. Relative doses were also measured as a function of the multi‐leaf collimator (MLC) leaf gap width. Subsequently, VMAT plans were created for prostate, pelvis, head and neck, liver, lung cancers and multiple brain metastases. Dose distributions and point doses were measured by multi‐dimensional detectors and ionization chambers for patient specific quality assurance, and comparisons were made between the two linacs.

Results

Dose differences in PDDs were all within ± 1% except the entrance region, and the averaged gamma indices of the lateral profiles were within 0.3. The differences in doses as a function of the MLC leaf gap width between the two linacs were within ±0.5%. For all the plans, gamma passing rates were all higher than 95% with criteria of 2%/2 mm. The average and the SD of dose differences on the multi‐dimensional detector between both measurements was 0.06 ± 2.12%, and the average of point dose differences was −0.03 ± 0.33%.

Conclusion

We have evaluated the AGL performance in the context of beam characteristics and patient specific QA. It was demonstrated that the AGL service provides an accurate VMAT treatment reproducibility for many tumor sites with gamma pass rates greater than 95% under criteria of 2%/2 mm.
A Roadmap Review of Thermally Conductive Polymer Composites: Critical Factors, Progress, and Prospects
Authors: Wang Zhengfang , Wu Zijian , Weng Ling , Ge Shengbo , Jiang Dawei , Huang Mina , Mulvihill Daniel M. , Chen Qingguo , Guo Zhanhu , Jazzar Abdullatif , He Ximin , Zhang Xuehua , Xu Ben Bin
Published: June 2023

Recently, the need for miniaturization and high integration have steered a strong technical wave in developing (micro‐)electronic devices. However, excessive amounts of heat may be generated during operation/charging, severely affecting device performance and leading to life/property loss. Benefiting from their low density, easy processing and low manufacturing cost, thermally conductive polymer composites have become a research hotspot to mitigate the disadvantage of excessive heat, with potential applications in 5G communication, electronic packaging and energy transmission. By far, the reported thermal conductivity coefficient (λ) of thermally conductive polymer composite is far from expectation. Deeper understanding of heat transfer mechanism is desired for developing next generation thermally conductive composites. This review holistically scopes current advances in this field, while giving special attention to critical factors that affect thermal conductivity in polymer composites as well as the thermal conduction mechanisms on how to enhance the λ value. This review covers critical factors such as interfacial thermal resistance, chain structure of polymer, intrinsic λ value of different thermally conductive fillers, orientation/configuration of nanoparticles, 3D interconnected networks, processing technology, etc. The applications of thermally conductive polymer composites in electronic devices are summarized. The existing problems are also discussed, new challenges and opportunities are prospected.
Direct Visualization of Chemically Resolved Multilayered Domains in Mixed‐Linker Metal–Organic Frameworks
Authors: Centrone Andrea , Lerma‐Berlanga Belen , Biacchi Adam J. , Fernández‐Conde Carmen , Pavlidis Georges , Marti‐Gastaldo Carlos
Published: June 2023

The modular synthesis approach for assembling inorganic nodes and organic multidentate linkers into reticular solids enables rational engineering in porous materials known as metal–organic frameworks (MOFs). Incorporation of two or more linker types in MOF crystals holds great potential for engineering complex pore functionalities, by virtue of chemically heterogeneous domains. However, deciphering linkers distributions in MOFs crystals is challenging because of the insufficient spatial resolution of conventional, chemically sensitive techniques hinders the verification of rational design. Herein, the high spatial resolution and chemical specificity of infrared nanoscopy is leveraged in combination with high‐throughput diffraction‐limited hyperspectral photoluminescence imaging to determine the composition of individual multivariate UiO‐68 MOF crystals (UiO, Universitetet‐i‐Oslo), after linker‐exchange with optically active tetrazine units. The results reveal that the crystals display a three‐layer onion‐like structure composed of a core‐rich in the parent linker, an intermediate multivariate layer with a gradient in linker composition and a proto‐MOF external shell. In this outer layer, a fraction of the linkers’ binding groups is hydrogen bonded rather than coordinated with metal nodes, suggestive of superficial reconstruction during the linker‐exchange. This study advances the analytical capabilities for studying and engineering heterogeneous domains in mixed‐linker MOF crystals down to the nanoscale.
Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity
Authors: Wang Huifeng , Duan Chongwen , Keate Rebecca L. , Ameer Guillermo A.
Published: June 2023

Impaired wound healing is a common complication for diabetic patients and effective diabetic wound management remains a clinical challenge. Furthermore, a significant problem that contributes to patient morbidity is the suboptimal quality of healed skin, which often leads to reoccurring chronic skin wounds. Herein, a novel compound and biomaterial building block, panthenol citrate (PC), is developed. It has interesting fluorescence and absorbance properties, and it is shown that PC can be used in soluble form as a wash solution and as a hydrogel dressing to address impaired wound healing in diabetes. PC exhibits antioxidant, antibacterial, anti‐inflammatory, and pro‐angiogenic properties, and promotes keratinocyte and dermal fibroblast migration and proliferation. When applied in a splinted excisional wound diabetic rodent model, PC improves re‐epithelialization, granulation tissue formation, and neovascularization. It also reduces inflammation and oxidative stress in the wound environment. Most importantly, it improves the regenerated tissue quality with enhanced mechanical strength and electrical properties. Therefore, PC could potentially improve wound care management for diabetic patients and play a beneficial role in other tissue regeneration applications.
3D‐Printed Patient‐Specific Circles of Willis with an Intracranial Aneurysm and their Application to Neurointerventional Endovascular Simulation
Authors: Kim Yeonwoo , Yang Hyeondong , Cho Kwang‐Chun , Kim Jung‐Jae , Kim Yong Bae , Oh Je Hoon
Published: June 2023

Cerebrovascular replicas are effective platforms that can simulate endovascular interventions in the treatment of intracranial aneurysm (IA), and an IA typically forms in the tortuously structured cerebral artery circulation known as the circle of Willis (CoW). Effective and reliable endovascular procedure simulation before actual clinical treatment is greatly helpful for neurosurgeons, but the simulation performance depends on how identical a CoW replica is to a patient's CoW. Herein, a tubular, transparent, and patient‐specific CoW replica is fabricated with realistic dimensions and elasticity using a combination of 3D printing and dip coating technique. First, a real‐scale CoW core substrate is constructed using an extrusion‐based 3D printing technology, then the thickness of the vascular wall is manipulated by coating the core substrate layer by layer, and finally the core substrate is dissolved to produce a tubular CoW structure. A liquid‐assisted dip coating method is utilized and optimized for uniform and high‐quality coating layers on the tortuous CoW core substrate. Moreover, the effectiveness of the CoW replica is demonstrated through an in‐house neurointerventional endovascular simulator. The proposed method paves a new way for practical and reliable endovascular simulations, which would help significantly improve the clinical outcomes of current IA treatments.
Structural Design of Oleogel‐Hydrogel Bigels for Co‐Delivery of Curcumin and Epigallocatechin Gallate with Synergistic Stability and Bioactivity
Authors: Yang Jingyi , Fu Yuhan , Zheng Hongxia , Jia Yan , Gao Yanxiang , Yin Shutao , Mao Like
Published: June 2023

Bigels are novel biphasic systems containing hydrogel and oleogel structures, which are designed to deliver multiple bioactives for synergistic activity. The current study develops bigels based on a carrageenan hydrogel and a monoglyceride (GMS) oleogel. Results show that the microstructures of bigels are facilely modified by two surface active ingredients (Tween 20 and polyglycerol polyricinoleate), which then influence the microstructures of the bigels. When curcumin and epigallocatechin gallate (EGCG) are delivered simultaneously, the bioactives work synergistically to slow thermal degradation. Simulated digestion tests indicate that the bigel structures can delay the release of the two bioactives in artificial saliva and simulated gastric fluid (SGF), and allow fast release in simulated intestinal fluid (SIF). DPPH and ABTS tests show the digested Tween 20 bigels containing EGCG and curcumin present synergistic antioxidant activity. Anticancer activity is evaluated in human colon adenocarcinoma HCT116, and the two bioactives work cooperatively to lower cell viability. The bioactives released from Tween 20 bigels have higher cytotoxicity than those from polyglycerol polyricinoleate bigels. The results reveal that facile structural design of bigels has the potential to achieve synergistic stability and bioactivity of co‐delivered bioactives, which is meaningful for the development of functional pharmaceutical, cosmetic, and food products.
Triplet–Triplet Annihilation Enhanced Deep‐Blue Organic Light‐Emitting Diodes by Naphtho[1,2‐d]imidazole‐Isomer Derivatives with Spin–Orbit Coupling
Authors: Yang Guo‐Xi , Liu Deng‐Hui , Gu Qing , Peng Xiaomei , Li De‐Li , Li Mengke , Liu Ming , Chen Jie , Liu Kunkun , Su Shi‐Jian
Published: June 2023

The utilization of triplet excitons is of great importance for organic light‐emitting diodes (OLEDs). Triplet–triplet annihilation (TTA) is one of the effective tactics to achieve high efficiency deep‐blue organic electroluminescence emitters by converting two triplet excitons into one singlet exciton. Whereas, in addition to the 25% electrogenerated singlet excitons, the proportion of radiative singlet excitons (RSE) produced by the TTA process is usually only 15%; thus the total radiative excitons are 40%. In this study, ≈35% of RSE is achieved by the TTA process (total 60%) with two deep‐blue emitters based on the isomeric naphthoimidazole (NI) unit and anthracene bridge. As a result, non‐doped OLEDs based on the two NI derivatives as emitting layers achieve maximum external quantum efficiencies of 10.9% and 11.2% with an identical deep‐blue emission peak of 452 nm, which are the best TTA OLEDs with a Commission Internationale de l'Eclairage chromaticity Y coordinate below 0.15. Theoretical and experimental results demonstrate that the TTA process can be improved owing to the efficient spin–orbit interactions, even though the energy levels of the triplet pairs are higher than the calculated second triplet excited states.
Diastereo‐ and Enantioselective Organocatalytic Synthesis of Spirocyclopropyl Pyrazolones
Authors: Carceller‐Ferrer Laura , Blay Gonzalo , Muñoz M. Carmen , Pedro José R. , Vila Carlos
Published: June 2023

A diastereo‐ and enantioselective synthesis of spirocyclopropylpyrazolones has been described through a Michael/alkylation cascade reaction of 4‐arylidenepyrazol‐5‐ones with diethyl 2‐bromomalonate catalyzed by (DHQ)2AQN. The reaction afforded selectively the corresponding spirocyclic compounds with 30–83% yield, diastereoselectivities ranging from 60:40 to >95:5 and 26–93% enantiomeric excess under mild reaction conditions. Moreover, we performed two selective transformations with the corresponding chiral compounds.
Shifts in flowering phenology in response to spring temperatures in eastern Tennessee
Authors: Faidiga Alexandra S. , Oliver Margaret G. , Budke Jessica M. , Kalisz Susan
Published: June 2023

Premise

Plant phenological shifts are among the clearest indicators of the effects of climate change. In North America, numerous studies in the northeastern United States have demonstrated earlier spring flowering compared to historical records. However, few studies have examined phenological shifts in the southeastern United States, a highly biodiverse region of North America characterized by dramatic variations in abiotic conditions over small geographic areas.

Methods

We examined 1000+ digitized herbarium records along with location‐specific temperature data to analyze phenological shifts of 14 spring‐flowering species in two adjacent ecoregions in eastern Tennessee.

Results

Spring‐flowering plant communities in the Blue Ridge and the Ridge and Valley ecoregions differed in their sensitivity to temperature; plants in the Ridge and Valley flower 0.73 days earlier/°C on average compared to 1.09 days/°C for plants in the Blue Ridge. Additionally, for the majority of species in both ecoregions, flowering is sensitive to spring temperature; i.e., in warmer years, most species flowered earlier. Despite this sensitivity, we did not find support for community‐level shifts in flowering within eastern Tennessee in recent decades, likely because increases in annual temperature in the southeast are driven primarily by warming summer (rather than spring) temperatures.

Conclusions

These results highlight the importance of including ecoregion as a predictor in phenological models for capturing variation in sensitivity among populations and suggest that even small shifts in temperature can have dramatic effects on phenology in response to climate in the southeastern United States.