bluuebunny/crossref_metadata_2025 huggingface dataset:
DETERMINANTES EM SAÚDE NO TERRITÓRIO BRASILEIRO PRÉ-PANDEMIA DE COVID-19
Authors: BARBOSA ALAN SALES , CAMARGO SÉRGIO XAVIER DE
Published: April 2023

O conceito atual de saúde é largamente visto e aplicado segundo define a Organização Mundial da Saúde (OMS) como um “estado de completo bem-estar físico, mental e social, e não simplesmente a ausência de doença ou enfermidade”. Essa perspectiva holística transforma tanto fatores intrínsecos quanto extrínsecos ao sujeito individual em fatores de sua posição como sujeito social, que modela e é modelado pela sociedade em que vive, de modo que todos esses fatores constituem os determinantes em saúde que, por essa conceituação, são aqui trabalhados. Portanto, estabeleceu-se o presente estudo com o objetivo geral de extrair os principais determinantes em saúde a partir de dados de diferentes macrorregiões socioeconômicas do Brasil na diversidade de cada uma delas, averiguando como esses determinantes dependem e podem guiar políticas públicas, algo especialmente importante no contexto de uma pandemia. Metodologicamente, fizeram-se comparações qualitativas de dados governamentais estaduais, regionais e nacionais, e análises críticas lógico-dedutivas ao intercorrelacionar fatores basais e determinantes e condições de saúde deles derivados, buscou-se alcançar informações sobre os principais determinantes sociais da saúde no Brasil como um todo. Observou-se significante mortalidade e morbidade por doenças infecciosas e parasitárias, um padrão de “terceiro mundo” principalmente nas macrorregiões Norte e Nordeste: genericamente, as menos urbanizadas, menos abundantes economicamente e com as maiores disparidades educacionais. Em todas as macrorrregiões, basicamente, observou-se deficiências na promoção e na prevenção em saúde por baixas acessibilidade e qualidade de atenção e de atendimento, bem como altos percentuais de acidentes de trabalho e de mortes evitáveis, relacionados com populações de baixa renda. Houve também aumento geral na mortalidade da população idosa, a despeito do aumento na expectativa de vida ao nascer, além de anos de vida insalubre por morbidades de doenças crônicas como neoplasias, diabete melito e condições cardiovasculares, respiratórias e neuropsiquiátricas, algo visto mesmo em regiões de maior abundância financeira e melhor alcance educacional, um “padrão de países desenvolvidos”. Concluíu-se que, não surpreendentemente, os principais determinantes estruturais em saúde do Brasil ainda são as condições de educação, ocupação profissional e renda (como mostrado no resumo gráfica deste trabalho), os quais, notavelmente, são corroborados pelas análises de dados das macrorregiões socioeconômicas brasileiras. O Brasil se apresenta em uma etapa de transição e, mesmo tendo um sistema de saúde constitucionalmente universal, integral, equânime e com participação popular, isso só se tornará verdade para o conceito de saúde contando com maiores investimentos governamentais e políticas públicas orientadas pelos dados em todas as esferas federativas.
Palavras-chave: Determinantes Sociais de Saúde; macrorregiões socioeconômicas brasileiras; pré-COVID-19.
Domestic Wastewater Treatment through the Application of Corchuros olitorius L. as Bio-Coagulant in Cagayan de Oro City, Philippines
Authors: Lacang Gina C. , Ligaray Corazon V.
Published: April 2023

This research paper presented the potential of Corchuros olitorius L. as a natural coagulant in the removal of turbidity, total suspended solids, and biochemical oxygen demand from the domestic wastewater of the University of Science and Technology of Southern Philippines. Optimization of the natural coagulant and synthetic coagulant was employed prior to the treatment design. The jar test method was used in the optimization and lab analysis including the gravimetric method, dilution technique, and digital measurements. The optimization results of Corchuros olitorius L. using the jar test method revealed better removal at a lower dosage of 50 mg/L and a higher settling time of 90 minutes. The characterization using FTIR analysis also suggests a functional group that influences coagulation activity. Using the optimum dose and optimum settling time, results with the different treatment designs showed the highest removal at pH 7 showed % BOD removal of 89.78% (A75C25); 85.98% (A25C75); 88.76% (A50C50). TSS removal measured values of 88.50% (A75C25), 85.56% (A25C75), and 87.16% (A50C50), while turbidity removal of 83.47% (A75C25), 80.27% (A25C75), and 80.27% (A50C50). Statistically, measured values differ between treatment designs. It is suggested to investigate removal efficiency in more varied pH conditions, different settling times, stirring speed, and other variables for future studies.
Desain Produk Case Handphone Berbahan Bioplastic dengan Memanfaatkan Limbah Ampas Tahu
Authors: Pattiapon Marcy Lolita , Maitimu Nil E.
Published: April 2023

Plastik merupakan produk polimer sintetis yang terbuat dari bahan-bahan petrokimia termasuk dalam sumber daya alam yang tidak dapat diperbahurui. Limbah plastik tidak hanya menjadi masalah di kalangan masyarakat umum tetapi juga menjadi masalah bagi perindustrian di Indonesia. Sampah plastik termasuk sampah non-organik yang butuh waktu sangat lama untuk dapat terdegradasi dengan sempurna. Plastik baru dapat terdegradasi dalam waktu 450 hingga 600 tahun. Dan hasil pengolahan data dengan memakai metode Quality Function Deployment (QDF) pada proses pembuatan produk case handhone (bioplastic) dari limbah ampas tahu ialah dapat meningkatkan keandalan produk, meningkatkan kualitas produk dan memenuhi kepuasan pelanggan. Serta produk yang dihasilkan mempunyai keandalan yaitu terurai dengan tanah. Produk prototype ini dapat dibuat dengan hasil pencampuran antara Ampas Tahu 25%, tepung maizena 50% dan Lem Silicone 25%, yang didesain dan dibuat sedemikian rupa sehingga menghasilkan produk prototype case handphone (bioplastic. Berdasarkan tes pasar yang dilakukan secara terbatas dan secara aplikasi yakni reability dan validasi dinyatakan valid atau diterima sesuai kriteria, dengan demikian produk yang dihasilkan sesuai dengan keinginan konsumen.
Implementation Fuzzy and Extended Kalman Filter for Estimation of High and Low Stock Price Travel Company
Authors: Susanto Ismanto Hadi , Katias Puspandam , Herlambang Teguh , Anshori Mohamad Yusak , Adinugroho Mukhtar
Published: April 2023

Competition in the business world is getting tougher from year to year both within a country and abroad. There are a large number of companies competing with one  another, especially entering the free market share in Asia, namely the Asean Economic Community (AEC). In the current development of modern economy, Indonesia is making efforts to increase its economic growth. For this, developments in any fields are made. Among others is the service industry such as accommodation, travel, and transportation services. Considering that Indonesia is a country comprised of many islands with a variety of natural beauty, it has the very potential for tourist resort attraction. This kind of thing leads to the growth of the Travel, tourism and hotel industry to support development of tourism. With such rapid service industry development, supported by promising business opportunities, investors for such sector are encouraged. The right way to reduce risk for investors interested is to develop a system for estimating the stock prices. Therefore, in this study, the high and low stock price estimation method applied for travel companies adopted developed Kalman Filter, a comparison of two Kalman Filter development methods, namely Extended Kalman Filter (EKF) and Fuzzy Kalman Filter (FKF) as a chart for investors to take into consideration in their investment decision making. The simulation results showed that the EKF method had higher accuracy than the FKF method with an error by the EKF of 3.5% and that by the FKF of 8.9%.
Interaction of praseodymium and dysprosium with oxygen in nickel melts at РAr = 0.1 MPa and analysis of nonmetallic inclusions
Authors:   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences (IMET RAS), Burtsev V. T. , Chabina E. B. ,   NRC “Kurchatov Institute” – VIAM, Anuchkin S. N. ,   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences (IMET RAS)
Published: April 2023

The interaction of Pr/Dy with oxygen in nickel melts at РAr = 0.1 MPa and constant temperature was studied by the method of instantaneous EMF fixation using a Mo[Cr/Cr2O3//ZrO2(MgO)//O(NiL)]Mo cell and certified sensors. Dependences a[O] = f[Pr/Dy, %] were expressed as logarithmic equations, which made it possible to compare them with each other in the concentration range of 0.001 – 0.2 % of each deoxidizer and determine that the deoxidizing capacity of Pr is 1.7 times higher in terms of compared to Dy. Calculated a[O] in Ni – O – Al – (Pr/Dy) melts compared to Al at a concentration of 0.05 % elements and showed a seven-fold decrease for the first deoxidizer and an eleven-fold decrease for the second. The morphology of non-metallic inclusions in metallographic sections of Ni – O – Pr/Dy alloys indicates that the inclusions are located along grain boundaries and have different configurations and complex heterophase composition. The analysis of non-metallic inclusions with the maximum content of the deoxidizing element proved the existence of Pr/Dy oxygen compounds, which confirms the data of thermodynamic and mass spectrometric studies. The average content of Zr in non-metallic inclusions during the deoxidation of Pr is twice as high as in the experiments during the deoxidation of Dy, which indicates the interaction of Pr/Dy with ZrO2 of the EMF sensor and the predominant interaction of Pr compared to Dy and correlates with the data on the determination of a[O].
Preparation of iron-based scaffolds with antibacterial coating based on polylactic acid and vancomycin
Authors:   Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS), Lozhkomoev А. S. , Kazantsev S. О. ,   Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS), Bakina О. V. ,   Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS), Buyakov А. S. ,   Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS), Senkina Е. I. ,   Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS), Krinitcyn М. G. ,   Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS), Ivanyuk V. А. ,   The National Research Tomsk Polytechnic University, Sharipova А. F. ,   Israel Institute of Technology, Lerner М. I. ,   Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS)
Published: April 2023

Bioresorption of implants is a widely studied phenomenon today. Complete degradation of the implant after performing its mechanical function is the safest outcome for the patient. It also excludes revision prosthetics. Promising materials include metals and composites based on them. Currently, research on the development of biorezorable nanocomposite structures based on iron is actively underway. Often during orthopedic surgery, infections can enter the patient’s body. Therefore, various ways of modifying the implants with antibiotics are being developed. One of the modification options suggests that an antibacterial coating on the surface of the scaffold can be obtained by impregnating it with solutions of bioresorbable polymers filled with drugs. Variation in polymer composition, antibiotic concentration, and impregnation cycles makes it possible to obtain the necessary drug release parameters to achieve an optimal therapeutic effect. Since the object of our study, iron, does not have antimicrobial properties, in this work we considered the possibility of modifying Fe scaffolds with vancomycin by impregnation with antibiotic solution and polylactic acid (PLA) solution containing vancomycin. The process of drug release in physiological solution (0.9 % NaCl) and antibacterial properties of the obtained materials were studied. The structure and composition of the scaffolds and mechanical characteristics were also investigated. It was shown that modification of the surface of the scaffolds with polylactic acid leads to an increase in the ultimate strength by 40 % and to an overall smoothing of the deformation curve. The study showed that the introduction of vancomycin into the polymer allows obtaining an antibacterial coating on the surface of the scaffold with a prolonged release of the drug.
On the prospects of using silicon dioxide obtained from mineral raw materials as an enterosorbent
Authors:   Tananaev Institute of Chemistry - Subdivision of the Federal Research Centre “Kola Science Centre of the Russian Academy of Sciences”, Mayorov D. V. , Velyaev Yu. O. ,   Sevastopol State University, Polytechnical Institute
Published: April 2023

Samples of amorphous silicon dioxide (SiO2) were obtained by acid decomposition of mineral raw materials (nepheline). Their physico-chemical, acid-base and structural-surface properties have been studied by methods of chemical analysis, Parks, BET, BJH, etc. It was found that in terms of the content of impurities, the pH of the aqueous extract, the pH values of the isoionic point and the zero charge point, the SiO2 samples obtained are almost identical to pyrogenic amorphous silicon dioxide obtained from reactive raw materials (pharmaceutical preparation “Polysorb PM”) and have an increased specific external surface compared to “Polysorb PM” (in 1.1 – 1.9 times) and specific pore volume (1.4 times). Based on the obtained values of the specific capacity of the adsorption monolayer of the surface of SiO2 samples and the change in Gibbs energy (ΔG0) during sorption, it is concluded that the method of their preparation does not significantly affect the physicochemical properties of their surfaces and the mechanism of nitrogen sorption. Based on the results obtained, an assumption is made about the prospects of using silicon dioxide, obtained on the basis of acid processing of mineral raw materials, as an enterosorbent in therapeutic practice.
Investigation of the polyvinylpyrrolidone amount as gelling agent to lanthanum cobaltite micropowders synthesize by sol-gel method
Authors:   Baikov Institute of Metallurgy and Materials Science of RAS, Ermakova E. A. , Strelnikova S. S. ,   Baikov Institute of Metallurgy and Materials Science of RAS, Anokhin A. S. ,   Baikov Institute of Metallurgy and Materials Science of RAS, Konovalov A. A. ,   Baikov Institute of Metallurgy and Materials Science of RAS, Antonova О. S. ,   Baikov Institute of Metallurgy and Materials Science of RAS, Chuvikina M. S. ,   Baikov Institute of Metallurgy and Materials Science of RAS
Published: April 2023

The paper focuses on lanthanum cobaltite micropowders LaCoO3-δ (LCO) synthesized by the sol-gel method using polyvinylpyrrolidone (PVP) as gelling agent. The PVP content has been varied from 0.5 to 5.0 wt. % when ionic solutions of the soluble raw components were prepared. The gels were dried in a microwave oven at microwave power 90 W for 2 h to evaporate water. Xerogels were thermally treated in a muffle furnace at temperatures 800°C and 900°C, the maximum holding time was 10 h and 30 h. After heat treatment of Xerogels at 800°C for 10 h LCO micropowders were slightly aggregated and particle size were in the range from 0.24 to 0.38 µm as well as specific surface area was in the range from 2.60 to 4.10 m2/g. After heat treatment 900°C for 10 h the specific surface area range of LCO micropowders decreased from 1.00 to 3.20 m2/g, but particle size range slightly increased from 0.31 up to 1.0 µm. Xerogels heat treatment at temperature 900° C for 30 h resulted to particles size range growing from 0.50 to 1.25 μm, and the specific surface area was 2.00 m2/g for all LCO micropowders. There was no effect of PVP content in the ionic solution on phase composition for all heat treated LCO micropowders.
Ion-beam formation of a silver-containing surface of porous silicon
Authors:   Yuri Gagarin State Technical University of Saratov, Perinsky V. V. , Perinskaya I. V. ,   Yuri Gagarin State Technical University of Saratov, Rodionov I. V. ,   Yuri Gagarin State Technical University of Saratov, Kuts L. E. ,   Yuri Gagarin State Technical University of Saratov
Published: April 2023

The results of a study of the formation of a silver-containing porous layer on the surface of single-crystal silicon KEF-4,5 by ion-beam alloying are presented. A computer simulation of the process of ion doping of silicon with KEF-4,5, high-energy helium and silver ions was carried out using the TRIM/SRIM software package in order to determine the dose and energy neighborhoods of helium and silver ions necessary and sufficient in the experiment. The relief of the porous surface, the density of quasi-pores on the surface of implanted silicon, the elemental composition of the obtained porous composite silver-containing layers, taking into account the effect of intermediate heat treatment on it, are studied. The ion-beam formation of a silver-containing coating ensures the creation of a developed surface relief at the nanoscale with high reproducibility and controllability inherent in the ion doping method, which contributes to an increase in the yield of usable solar cell products. The technological modes of high reproducibility and controllability inherent in the ion doping method are determined based on the experimental data obtained for studying the relief of a porous surface and the density of quasi-pores on the surface of implanted silicon from the energy and dose of helium ions. Based on the study of the elemental composition of the quasi-porous composite silver-containing layer obtained by implantation of silver ions, the recommended parameters of implantation of silver ions have been established.
Investigation of the influence of carbon fillers on the manifestation of the effect of tensoresistivity in tire regenerates
Authors:   Institute of oil and gas problems SB RAS of FRC Yakut science center SB RAS, Shadrinov N. V. , Antoev K. P. ,   Institute of oil and gas problems SB RAS of FRC Yakut science center SB RAS
Published: April 2023

An opportunity of development of electrically conductive rubber based on industrially produced tyre regenerate RShT-4 and Reg-1, obtained in laboratory conditions, with electrically conductive carbon fillers is shown. OMCARB CH85 carbon black (CB) produced by “Omsktehuglerod” Ltd. and Tenax-e HTS-45 carbon fibres (CF) produced by Toho Tenax America were used as electrically conductive fillers. Curing and rheometric properties of regenerates with different content of Santogard PVI and electroconductive fillers have been investigated. The study of physical and mechanical properties of regenerates has shown that introduction and increase of electroconductive CB and CF content in Reg-1 and RShT-4 leads to gradual reduction of elongation at break and increase in tensile strength and Shore A hardness, which is evidence of reinforcing effect of fillers. The effect of tensoresistance in the obtained regenerates depending on the content of electroconductive fillers is investigated. It is shown that addition of electroconductive CB to Reg-1 and RSHT-4 gives electroconductivity and tensoresistivity, that is, decrease of resistance in compression. Addition of CF leads to the opposite effect - increase of electrical resistance in compression. The possible mechanisms for the manifistation of tensoresistance at introduction of electroconductive CB and decrease of electroconductivity at introduction of CF are offered.
Spark Plasma Sintering of ultrafine-grained WC – Al2O3 ceramics
Authors:   National Research Lobachevsky State University of Nizhny Novgorod, Lantsev E. A. , Nokhrin A. V. ,   National Research Lobachevsky State University of Nizhny Novgorod, Boldin M. S. ,   National Research Lobachevsky State University of Nizhny Novgorod, Smetanina K. E. ,   National Research Lobachevsky State University of Nizhny Novgorod, Murashov A. A. ,   National Research Lobachevsky State University of Nizhny Novgorod, Blagoveshchenskiy Yu. V. ,   Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Isaeva N. V. ,   Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Shcherbak G. V. ,   National Research Lobachevsky State University of Nizhny Novgorod, Chuvil’deev V. N. ,   National Research Lobachevsky State University of Nizhny Novgorod, Tabachkova N. Yu. ,   National University of Science and Technology “MISIS”, Terentyev A. V. ,   Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Published: April 2023

The sintering mechanisms of WC – Al2O3 nanopowder compositions with different contents of aluminum oxide particles (1, 3, 5 wt.%) were investigated. Samples of WC – Al2O3 ceramics were produced by Spark Plasma Sintering method (SPS) in vacuum, by heating to a temperature of 1450 °C at a rate of 50 °C/min under uniaxial stress 70 MPa. Plasma-chemical nanopowders of tungsten monocarbide and submicron powders of aluminum oxide were used to make the ceramics. The density, microstructure, phase composition, microhardness (Hv) and fracture toughness (KIC) of the ceramics were investigated. It was shown that the use of the SPS method makes it possible to obtain WC-Al2O3 ceramics with good relative density (95.4-98.1%) and a homogeneous microstructure with ultrafine grain size (0.1 – 0.2 μm). By the method of the X-ray phase analysis, it was established that in the process of SPS of WC-Al2O3 ceramics the formation of an undesirable W2C phase takes place, leading to decrease in the fracture toughness KIC. To reduce the intensity of W2C particle formation, colloidal graphite (0.1, 0.2, 0.3 wt.%) was added to WC – Al2O3 ceramics. Using the Young-Cutler model and the model of diffusion resorption of pores it was shown that the main mechanism of SPS of WC – Al2O3 ceramics is grain boundary diffusion. It is shown that the introduction of graphite leads to a decrease in the activation energy of SPS of WC – Al2O3 ceramics, which is probably due to a decrease in the W2C particle content to 0.5 wt.%.
Prospective mathematics teachers’ views of their learning in a lesson study
Authors: Mendes da Ponte João Pedro , Quaresma Marisa , Mata-Pereira Joana
Published: April 2023

We aim to identify what prospective mathematics teachers indicated that they learned regarding mathematics and mathematics teaching as they participated in a lesson study. The theoretical framework is supported by models about teachers’ knowledge and prospective teachers learning processes. The methodology is qualitative and interpretative, with data collected by interviews and documents made by participants. The participants indicated to understand the importance of different representations in mathematics. They also indicated to appreciate the value of the detailed planning of the lesson, the careful selection of tasks, the analysis of possible student strategies and difficulties, and the preparation of classroom communication.
Trabajo con igualdades numéricas para promover pensamiento relacional

Authors: Molina Marta , Castro Encarnación , Ambrose Rebecca
Published: April 2023

En este documento presentamos algunos de los resultados de un estudio que aporta evidencias de la capacidad, de los alumnos de tercero de educación primaria, para desarrollar pensamiento relacional y comprensión del significado del signo igual “equivalencia numérica”, trabajando en un contexto de igualdades numéricas. Working with Numeric Equalities for Promoting Relational Thinking In this document we present some of the results of a study which provides evidence of third grade students´ capacity to develop relational thinking and understanding of the meaning of the equal sign “numerical equivalence”, both in a context of number sentences.Handle: http://hdl.handle.net/10481/3473Nº de citas en WOS (2017): 4 (citas de 2º orden, 1)Nº de citas en SCOPUS (2017): 3 (citas de 2º orden, 2)
Patrones, generalización y estrategias inductivas de estudiantes de 3º y 4º de Educación Secundaria Obligatoria en el problema de las baldosas

Authors: Cañadas María C. , Castro Encarnación , Castro Enrique
Published: April 2023

En este trabajo describimos los patrones y la generalización que llevan a cabo 359 estudiantes de 3º y 4º de Educación Secundaria Obligatoria en la resolución del problema de las baldosas. Prestamos especial atención a los tipos de patrones identificados, a la forma en que los estudiantes expresan la generalización y, mediante la descripción de las estrategias inductivas, presentamos algunas características de la generalización referentes a los elementos y a los sistemas de representación utilizados. Patterns, Generalization and Inductive Strategies of Secondary Students Working on the Tiles Problem In this paper we explore the patterns and the generalization developed by 359 students in years 9 and 10 in the resolution of the tiles problem. We pay special attention to the kinds of patterns identified, to the written ways in which students express generalization and, using inductive strategies, we present some characteristics of the generalization relating to the elements and the representations used.Handle: http://hdl.handle.net/10481/4392Nº de citas en WOS (2017): 4 (Citas de 2º orden, 6)Nº de citas en SCOPUS (2017): 1 (Citas de 2º orden, 0)
Revisiting university students’ knowledge that involves basic differential equation questions

Authors: Camacho Matías , Perdomo Josefa , Santos-Trigo Manuel
Published: April 2023

This study documents the extent to which university students utilize diverse representations and mathematical processes to interpret and respond to a set of questions that involves fundamental concepts in the study of differential equations. Results indicate that students’ idea to solve a differential equation is reduced to the application of proper solution methods to a certain type of equation differential expressions. Thus, instructional activities should promote the students’ use of several representation systems in which they can reflect on the various aspects associated with the concept itself, the solution methods, procedures, and the corresponding meaning and connections among those representations. Conocimiento de los Estudiantes Universitarios con Respecto a Preguntas que Implican Ecuaciones Diferenciales: una Revisión Este estudio muestra hasta qué punto los estudiantes de universidad utilizan diferentes procesos y representaciones matemáticas para interpretar y responder a un grupo de cuestiones que incluyen conceptos fundamentales relacionados con el estudio de las ecuaciones diferenciales. Los resultados obtenidos indican que la idea que tienen los estudiantes de resolver una ecuación diferencial, se reduce a la aplicación de una serie de métodos. Así, la instrucción debería promover el uso de diferentes sistemas de representación que les permita reflexionar sobre varios aspectos asociados al concepto, los métodos de solución, los procedimientos y los significados y conexiones entre las representaciones utilizadas.Handle: http://hdl.handle.net/10481/3512Nº de citas en WOS (2017): 1 (Citas de 2º orden, 0)Nº de citas en SCOPUS (2017): 1 (Citas de 2º orden, 0)
Layers of generality and types of generalization in pattern activities

Authors: Radford Luis
Published: April 2023

Pattern generalization is considered one of the prominent routes for introducing students to algebra. However, not all generalizations are algebraic. In the use of pattern generalization as a route to algebra, we —teachers and educators— thus have to remain vigilant in order not to confound algebraic generalizations with other forms of dealing with the general. But how to distinguish between algebraic and non-algebraic generalizations? On epistemological and semiotic grounds, in this article I suggest a characterization of algebraic generalizations. This characterization helps to bring about a typology of algebraic and arithmetic generalizations. The typology is illustrated with classroom examples. Niveles de generalidad y tipos de generalizaciones en actividades de patrones La generalización de patrones es considerada como una de las formas más importantes de introducir el algebra en la escuela. Sin embargo, no todas las generalizaciones de patrones son algebraicas. Como consecuencia, en el uso de patrones como recurso didáctico, se debe tener mucho cuidado en no confundir generalizaciones algebraicas con otras formas de generalización. Ahora bien, ¿cómo distinguir entre las unas y las otras? En este articulo, basado en ideas epistemológicas y semióticas, sugiero una caracterización de generalizaciones algebraicas. Dicha caracterización permite establecer una tipología, la cual es ilustrada a través de ejemplos concretos.Handle: http://hdl.handle.net/10481/3505Nº de citas en WOS (2017): 13 (Citas de 2º orden, 7)Nº de citas en SCOPUS (2017): 6 (Citas de 2º orden, 4)
¿Qué comprensión de la fracción fomentan los libros de texto de matemáticas peruanos?

Authors: Quispe Wenceslao , Gallardo Jesús , González José Luis
Published: April 2023

Para valorar la comprensión de la fracción en Perú desde una perspectiva curricular, realizamos un análisis de 20 libros de texto peruanos de matemáticas (1963-2005). El análisis se fundamenta en la dimensión fenómeno-epistemológica de un modelo operativo para la interpretación de la comprensión en matemáticas. Se pone la atención sobre los significados, las representaciones e ilustraciones, la fenomenología y la orientación metodológica. Atendiendo a estos elementos, identificamos 3 periodos con carencias en la comprensión pero con una cierta evolución positiva en el tratamiento didáctico de la fracción. Con el propósito de mejorar esta situación, presentamos algunas recomendaciones que pueden resultar eficaces en el desarrollo de la comprensión de la fracción. What understanding of fraction support the peruvians mathematics textbooks? To assess the understanding of fraction in Peru from a curricular perspective, we realize an analysis of 20 Peruvian mathematics textbooks (1963-2005). The analysis is based on the phenomenon-epistemological dimension of an operative model for interpreting the understanding in mathematics. The attention is posed in the meanings, the representations and illustrations, the phenomenology and the methodological orientation. From these elements, we identify 3 periods with limitations in the understanding but with a certain positive evolution in the didactic treatment of fraction. Within the purpose of improving this situation, wepresent some recommendations that can be efficient to develop the understanding of fraction. Handle: http://hdl.handle.net/10481/3504
Collaborating, Collecting, and Diversifying
Authors: Soma Caitlin
Published: April 2023

As part of ongoing efforts to diversify a historically white, Western theological library collection, Pitts Theology Library is using library endowment funds to build up underrepresented areas of the collection. This paper shows the process of creating a collection of Korean language materials while working with students, faculty, international vendors, and librarians across Emory University.
Onboarding OpenAthens
Authors: Leffler David
Published: April 2023

Liberty University is a private, Christian university in Lynchburg, Virginia. OpenAthens is a company that provides off-campus authentication for an organization’s electronic resources by redirecting URLs through a secure network. In 2022, Liberty University took action to begin transitioning from EZproxy authentication to OpenAthens authentication. There are three primary reasons why Liberty University chose to authenticate its electronic resources through OpenAthens:

OpenAthens provides greater security for accessing electronic resources by providing federated access for specific subscriptions.

OpenAthens requires less internal support to maintain access to electronic resources, such as the lack of requirement to maintain stanza updates, than other authentication products.

OpenAthens provides more granular reporting capabilities for usage data.

Therefore, organizations that plan to switch to OpenAthens authentication should consider their testing methods, plan for liaising with OpenAthens, and gain knowledge of OpenAthens terminology and different electronic environments before implementation to ensure a smooth onboarding experience.
Benefits of Pelvic and Para-Aortic Lymphadenectomy after Neoadjuvant Chemotherapy for Advanced Epithelial Ovarian Cancer with Enlarged Lymph Nodes
Authors: Kubo-Kaneda Michiko , Kondo Eiji , Enomoto Naosuke , Okamoto Kota , Toriyabe Kuniaki , Nii Masafumi , Yoshida Kenta , Ikeda Tomoaki
Published: April 2023

Background: This study aimed to evaluate the effectiveness of pelvic and para-aortic lymphadenectomy in patients with advanced epithelial ovarian cancer following neoadjuvant chemotherapy. Methods: This single-center retrospective study analyzed patients with advanced epithelial ovarian cancer who underwent interval debulking surgery between December 2008 and March 2020. Patients’ clinical and pathological data were obtained from medical records. Statistical analyses were performed using the Fisher’s exact and Mann–Whitney U test. Results: Overall, 33 and 22 patients were included in the lymphadenectomy and no-lymphadenectomy groups, respectively. The lymphadenectomy group had longer operative time and higher rates of intraoperative blood loss and lymph cysts than the no-lymphadenectomy group (p < 0.0001). The median progression-free survival (PFS) was longer in the lymphadenectomy group than in the no-lymphadenectomy group (37.0 vs. 20.0 months, p = 0.038). Among patients with enlarged lymph nodes before chemotherapy, the median PFS was longer in the lymphadenectomy group than in the no-lymphadenectomy group (36.0 vs. 15.0 months, p = 0.013). Multivariate analysis of all patients revealed that residual tumor status (p = 0.002) and histology (p = 0.009) were associated with PFS. Additionally, multivariate analysis of patients with enlarged lymph nodes before chemotherapy showed that lymphadenectomy (p = 0.017) and histology (p = 0.021) were associated with PFS. Conclusions: Systematic lymphadenectomy was associated with complications; however, PFS was significantly prolonged in patients with enlarged lymph nodes in the lymphadenectomy group. Therefore, lymphadenectomy has the potential to improve prognosis in patients with ovarian cancer and enlarged lymph nodes.
Predictive Model of Cesarean Hysterectomy Accompanying Cesarean Section in Patients with Placenta Previa
Authors: Choi Myeong Gyun , Kim Jong Woon , Kim Yoon Ha
Published: April 2023

Background: The purpose of this study was to develop a model to predict cesarean hysterectomy accompanying cesarean section in patients with placenta previa. Methods: We retrospectively reviewed 926 patients diagnosed with placenta previa who had cesarean section from January 2011 to December 2021. We analyzed data by independent t-test and Pearson’s chi-squared test. Multivariate logistic regression analysis was used to develop a predictive model and identify factors predictive for cesarean hysterectomy accompanying cesarean section. Results: A total of 44 cesarean hysterectomies (4.8%) were performed in 926 patients with placenta previa. History of cesarean section (1 (odds ratio (OR) 13.57, 95% confidence interval (CI) 4.29–42.96), ≥2 (OR 83.28, 95% CI 21.98–315.55)), anterior placenta (OR 3.06, 95% CI 1.22–7.68), adherent placenta (OR 8.78, 95% CI 3.65–21.09), presence of lacuna (OR 3.74, 95% CI 1.55–9.04), and old maternal age (≥40 years (OR 4.65, 95% CI 1.60–13.49)) were factors selected to develop a model to predict cesarean hysterectomy. Based on this model, an equation was developed and tested for performance. This model using five factors yielded an area under the curve of 0.951 (95% CI 0.921–0.981) to predict the probability of cesarean hysterectomy accompanying cesarean section. Conclusions: Application of this predictive model may provide an effective prediction of cesarean hysterectomy in patients with placenta previa. Adequate pre-operative preparation and intraoperative strategies can be indicated based on this model.
Evaluation on the Effectiveness of High Cholesterol Diet Feeding in Inducing Early and Established Atherosclerotic Lesions in New Zealand White Rabbits
Authors: Abd Rahim Iman Nabilah , Mohd Kasim Noor Alicezah , Omar Effat , Abd Muid Suhaila , Nawawi Hapizah
Published: April 2023

Background: Various methods were used to induce atherosclerosis in rabbits. One of the most common methods used is high-cholesterol diet (HCD) feeding. However, the exact amount and duration of HCD feeding to induce early and established atherosclerosis in New Zealand white rabbits (NZWR) continue to be debated among researchers. Therefore, this study aims to evaluate the effectiveness of 1% HCD feeding in inducing early and established atherosclerosis lesions in NZWR. Methods: A total of 50 g/kg/day of 1% HCD was fed to three to four months old male rabbits weighing 1.8 to 2.0 kg for four and eight weeks to induce early and established atherosclerosis respectively. The body weight and lipid profile were measured at baseline and post-HCD intervention. Following euthanasia, the aorta was excised and prepared for histology and immunohistochemical analysis to confirm the stages of atherosclerosis. Results: The mean body weight of the rabbits in early and established atherosclerosis groups increased significantly up to 17.5% (p = 0.026) and 19.75% (p = 0.019) respectively compared to baseline. The total cholesterol level dramatically elevated up to 13-fold (p = 0.005) and 38-fold (p = 0.013) compared to baseline, after four and eight weeks of 1% HCD feeding respectively. The low-density lipoprotein level significantly increased up to 42-fold (p = 0.006) and 128-fold (p = 0.011) compared to baseline, after four and eight weeks of 1% HCD feeding respectively. Rabbits fed with four and eight weeks 1% HCD significantly developed 5.79% (p = 0.008) and 21.52% (p = 0.008) aortic lesion areas compared to the control group. Histological evaluation in the aorta showed accumulation of foam cells in early atherosclerosis group and formation of fibrous plaque and lipid core in the established atherosclerosis group. Rabbits fed with eight weeks HCD showed higher tissue expressions of ICAM-1, VCAM-1, e-selectin, IL-6, IL-8, NF-κBp65, and MMP-12 compared to four weeks of HCD intervention. Conclusions: A total of 50 g/kg/day of 1% HCD for four and eight weeks is sufficient to induce early and established atherosclerosis in NZWR respectively. The consistent results through this method could facilitate researchers in inducing early and established atherosclerosis in NZWR.
Long Noncoding RNAs in Ovarian Cancer—Functions and Clinical Applications
Authors: Zhong Lili , Li Xin , Wang Yicun , Liu Bin , Ding Xiangfu , Zhao Yinlong
Published: April 2023

Long noncoding RNAs (lncRNAs) are RNA molecules with a length of more than 200 nt that have been discovered in recent years. LncRNAs can participate in regulating gene expression and various biological activities through multiple pathways, such as at the epigenetic level, transcriptional level, and posttranscriptional level. In recent years, with the increasing understanding of lncRNAs, a large number of studies have shown that lncRNAs are closely related to ovarian cancer and participate in its occurrence and development, providing a new method to investigate ovarian cancer. In this review, we analyzed and summarized the relationship between various lncRNAs and ovarian cancer in terms of occurrence, development, and clinical significance, in order to provide a theoretical basis for basic research and clinical application of ovarian cancer.
Effects of Sepsis Serum on the Fate of Adipose Tissue-Derived Stem Cells
Authors: Fang Junbiao , Lu Ruijie , Lin Yujie , Wang Hongfa , Wei Hanwei , Wang Junkai , Liu Qiaoyan , Liu Huizi , Zhou Zhenfeng , Zhang Ling , Pan Ruolang , Chen Yue
Published: April 2023

Background: Adipose tissue-derived stem cells (ADSCs), a type of mesenchymal stem cell, have been used extensively in clinical trials for the treatment of multiple conditions, including sepsis. However, increasing evidence indicates that ADSCs vanish from tissues within days of administration. Consequently, it would be desirable to establish the mechanisms underlying the fate of ADSCs following transplantation. Methods: In this study, sepsis serum from mouse models was used to mimic microenvironmental effects. Healthy donor-derived human ADSCs were cultured in vitro in the presence of mouse serum from normal or lipopolysaccharide (LPS)-induced sepsis models for the purposes of discriminant analysis. The effects of sepsis serum on ADSC surface markers and cell differentiation were analyzed by flow cytometry, and the proliferation of ADSCs was assessed using a Cell Counting Kit-8 (CCK-8) assay. Quantitative real-time PCR (qRT-PCR) was applied to assess the degree of ADSC differentiation. The effects of sepsis serum on the cytokine release and migration of ADSCs were determined based on ELISA and Transwell assays, respectively, and ADSC senescence was assessed by β-galactosidase staining and western blotting. Furthermore, we performed metabolic profiling to determine the rates of extracellular acidification and oxidative phosphorylation and the production of adenosine triphosphate and reactive oxygen species. Results: We found that sepsis serum enhanced the cytokine and growth factor secretion and migratory capacities of ADSCs. Moreover, the metabolic pattern of these cells was reprogrammed to a more activated oxidative phosphorylation stage, leading to an increase in osteoblastic differentiation capacity and reductions in adipogenesis and chondrogenesis. Conclusions: Our findings in this study reveal that a septic microenvironment can regulate the fate of ADSCs.
Ethanol Preference Leads to Alterations in Telomere Length, Mitochondria Copy Number, and Antioxidant Enzyme Activity in Zebrafish Brains
Authors: Moraes Izabela Barbosa , Paiva Isadora Marques , Moreira-Júnior Renato Elias , Sartori Bárbara Miranda , Franco Rodrigo Rodrigues , Espindola Foued Salmen , Murgas Luis David Solis , Brunialti-Godard Ana Lúcia
Published: April 2023

Background: The motivations for and effects of ethanol consumption vary considerably among individuals, and as such, a significant proportion of the population is prone to substance abuse and its negative consequences in the physical, social, and psychological spheres. In a biological context, the characterization of these phenotypes provides clues for understanding the neurological complexity associated with ethanol abuse behavior. Therefore, the objective of this research was to characterize four ethanol preference phenotypes described in zebrafish: Light, Heavy, Inflexible, and Negative Reinforcement. Methods: To do this, we evaluated the telomere length, mtDNA copy number using real-time quantitative PCR (qPCR), and the activity of these antioxidant enzymes: catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the brain, and the interactions between these biomarkers. Changes observed in these parameters were associated with ethanol consumption and alcohol abuse. Results: The Heavy, Inflexible, and Negative Reinforcement phenotypes showed ethanol preference. This was particularly the case with the Inflexible phenotype, which was the group with the greatest ethanol preference. These three phenotypes showed telomere shortening as well as high SOD/CAT and/or GPx activities, while the Heavy phenotype also showed an increase in the mtDNA copy number. However, the Light phenotype, containing individuals without ethanol preference, did not demonstrate any changes in the analyzed parameters even after being exposed to the drug. Additionally, the PCA analysis showed a tendency to cluster the Light and Control groups differently from the other ethanol preference phenotypes. There was also a negative correlation between the results of the relative telomere length and SOD and CAT activity, providing further evidence of the biological relationship between these parameters. Conclusions: Our results showed differential molecular and biochemistry patterns in individuals with ethanol preference, suggesting that the molecular and biochemical basis of alcohol abuse behavior extends beyond its harmful physiological effects, but rather is correlated with preference phenotypes.
Galectin-1 Regulates RNA Expression and Alternative Splicing of Angiogenic Genes in HUVECs
Authors: Wei Jiajun , Wu Yunfei , Sun Yue , Chen Dong
Published: April 2023

Background: Angiogenesis is essential for tissue development, and therefore its dysregulation can cause various diseases, including cerebrovascular disease. Galectin-1, encoded by the lectin galactoside-binding soluble-1 gene (LGALS1), has critical roles in the regulation of angiogenesis, but the underlying mechanisms need further clarification. Methods: LGALS1 was silenced in human umbilical vein endothelial cells (HUVECs) and whole transcriptome sequencing (RNA-seq) was then performed to investigate potential targets for galectin-1. Galectin-1-interacting RNA data was also integrated to explore how galectin-1 might regulate gene expression and alternative splicing (AS). Results: A total of 1451 differentially expressed genes (DEGs) were found to be regulated by silencing LGALS1 (siLGALS1), comprising 604 up- and 847 down-regulated DEGs. Down-regulated DEGs were primarily enriched in angiogenesis and inflammatory response pathways, and included CCL2, GJA5, CALCRL, ACKR3, HEY1, AQP1, CD34, ECM1, RAMP2, and SELP. These were validated by reverse transcription and quantitative polymerase chain reaction (RT-qPCR) experiments. siLGALS1 was also used to analyze dysregulated AS profiles, such as the promotion of exon skipping (ES) and intron retention, and inhibition of cassette exon events. Interestingly, regulated AS genes (RASGs) were found to be enriched in focal adhesion and in the angiogenesis-associated vascular endothelial growth factor (VEGF) signaling pathway. Furthermore, based on our previously published RNA interactome data for galectin-1, hundreds of RASGs were found to be bound by galectin-1, including those enriched in the angiogenesis pathway. Conclusions: Our results demonstrate that galectin-1 can regulate angiogenesis-related genes at transcriptional and post-transcriptional levels, probably by binding to the transcripts. These findings expand our understanding of the functions of galectin-1 and the molecular mechanisms that underlie angiogenesis. They also indicate that galectin-1 could serve as a therapeutic target for future anti-angiogenic treatments.
The Roles of Microtubule-Associated Protein 4 in Wound Healing and Human Diseases
Authors: Chen Qiquan , Zhang Junhui , Song Zhiqiang , Huang Yuesheng
Published: April 2023

Microtubules (MTs) are essential structural elements of cells. MT stability and dynamics play key roles in integrity of cell morphology and various cellular activities. The MT-associated proteins (MAPs) are specialized proteins that interact with MT and induce MT assemble into distinct arrays. Microtubule-associated protein 4 (MAP4), a member of MAPs family, ubiquitously expressed in both neuronal and non-neuronal cells and tissues, plays a key role in regulating MT stability. Over the past 40 years or so, the mechanism of MAP4 regulating MT stability has been well studied. In recent years, more and more studies have found that MAP4 affects the activities of sundry human cells through regulating MT stability with different signaling pathways, plays important roles in the pathogenesis of a number of disorders. The aim of this review is to outline the detailed regulatory mechanisms of MAP4 in MT stability, and to focus on its specific mechanisms in wound healing and various human diseases, thus to highlight the possibility of MAP4 as a future therapeutic target for accelerating wound healing and treating other disorders.