bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Development of an Intelligent Laboratory Management System Based on STM Processors
Authors: Wang Ruoyu , Chen Lulu , Liu Jiaxuan , Tian Lei
Published: October 2024

In response to the escalating inventory of laboratory equipment, the inadequacy of traditional manual management practices has become increasingly apparent. Current management challenges are underscored by historical data, which reveals a borrowing rate of approximately 30%, a concerning return rate of only about 5%, and an equipment loss rate of 10%. To address these inefficiencies, this paper introduces an advanced, intelligent laboratory equipment management system leveraging STM32 and GM65 technologies, designed to significantly enhance the return rate and minimize equipment loss. The system is meticulously engineered, featuring three integral modules: the scanning module, the core board module, and the communication module. The scanning module employs GM65 technology to rapidly scan and decode QR codes, facilitating the swift transmission of critical data to the core board for intelligent processing and interaction with the laboratory equipment. At the heart of the system, the core board module serves as the central processing unit, adeptly managing data from the scanning module. It intelligently discerns various information types and dynamically updates the TFT-LCD screen with the current status of equipment, ensuring that all users have access to real-time and accurate information regarding the borrowing and returning of equipment. The communication module is pivotal in bolstering the system's connectivity capabilities. Designed with a robust structure, the system is characterized by its simplicity of operation and robust practicality. It not only significantly improves the efficiency of laboratory equipment management but also plays a transformative role in modernizing laboratory management practices. By streamlining the management process and ensuring the optimal utilization of resources, this system provides a solid foundation for the sustainable advancement of laboratory operations.
9D Rotation Representation-SVD Fusion with Deep Learning for Unconstrained Head Pose Estimation
Authors: Lyu Jiaqi , Wang Changyuan
Published: October 2024

Accurately estimating human head pose poses a significant challenge across various application domains. To address the inherent limitations of previous approaches, this research proposes an unconstrained head pose estimation strategy. The method combines deep learning with rotation matrices, utilizing nine-dimensional vectors output by the neural network, which are projected back to rotation matrices in SO (3) space through singular value decomposition. This ensures both the smoothness and uniqueness of the rotation representation. The approach demonstrates distinct advantages in handling the rotation estimation task, particularly when the rotated representation is used as the model output. It not only avoids the discontinuity and double-coverage issues associated with prior methods but also enhances the stability of the representation in high-dimensional space, thereby improving the learning process. Additionally, the geodesic loss function is incorporated to train the network. The proposed strategy surpasses previous state-of-the-art methods, as evidenced by experiments conducted on the AFLW2000 and BIWI datasets.
Improved Pedestrian Vehicle Detection for Small Objects Based on Attention Mechanism
Authors: Hao Yanpeng , Geng Chaoyang
Published: October 2024

This study aims to solve the low detection accuracy and susceptibility to false detection and omission in pedestrian and vehicle detection by proposing an improved YOLOv5s algorithm. Firstly, a small target detection module is added to better acquire and determine the information of pedestrians from long-range vehicles. Secondly, the multi-scale channel attention CBAM attention module is added, and the dual attention mechanism is not only flexible and convenient, but also improves the computational efficiency. Finally, the MPDIoU loss function based on minimum point distance is introduced to replace the original GIoU loss function, and this change not only enhances the regression accuracy of the model. At the same time, the convergence speed of the model is accelerated. KITTI data set was used for experiments, and the experimental results showed that the average accuracy of the model trained by the improved YOLOv5s algorithm on the data set reached 84.9%, which was 3.7% higher than that of the original YOLOv5s algorithm. It is verified that the model is suitable for high accuracy of pedestrian and vehicle recognition in complex environments, and has high value for promotion.
The effect of consumption of cranberry (Vaccinium macrocarpon) on Escherichia coli adherence to feline uroepithelial cells in a blind randomised cross-over trial in cats
Authors: Carvajal-Campos Amaranta , Trebossen Lucile , Jeusette Isabelle , Mayot Gilles , Torre Celina , Fragua Victor , Fernandez Anna , Martino Patrick Di
Published: October 2024

Introduction

Escherichia coli is the most common uropathogen in humans, dogs and cats. Dietary consumption of cranberry (Vaccinium macrocarpon) is known to be associated with a reduction in uropathogenic E. coli (UPEC) adhesion to human and canine urinary epithelial cell lines, but this has not been shown in cats.

Material and Methods

Six neutered domestic cats, one male and five females, were randomly fed three diets successively, one containing 0.1% cranberry powder, one containing 0.3% cranberry powder, and one being the control without cranberry. Naturally emitted urine was collected on the last two days of each period of two weeks and used for bacterial growth. Adherence to Crandell-Rees feline kidney (CRFK) uroepithelial cells of the feline UPEC C571 strain (positive for the papC gene marker for P-fimbriae and the fimA marker for type 1 pili and negative for the gene of the alpha haemolysin cytotoxin hlyA, and additionally non-haemolytic in vitro on blood agar) was quantified after growth in urine samples.

Results

Significant reductions in bacterial adherence to CRFK cells were observed for 60% of cats receiving 0.1% cranberry powder supplementation and for all cats receiving 0.3% cranberry powder supplementation, compared to the same animals consuming the control diet.

Conclusion

Dietary supplementation with cranberry may provide some degree of protection to cats against adhesion of UPEC to feline uroepithelial cells.
Analysis of Conflict and Challenges in the Hospital Environment that Impact the Patient’s Exercise of Private Autonomy
Authors: Soalheiro Luiza
Published: October 2024

Objective: This article aims to investigate conflict and the challenges present in the hospital environment, seeking to understand its possible impacts on the construction of the patient's private autonomy.
 
Theoretical Framework: The theoretical framework is based on the idea that conflict is inherent to human relationships and, therefore, its elimination is not sought, but rather its transformation. Thus, a view of conflict is presented that goes beyond the traditional negative view, highlighting its positive potential, based mainly on the ideas of authors such as Morton Deutsch and John Nash.
 
Method: Using the theoretical, legal-descriptive methodology, mediation will be presented as a potential method for dealing with conflicts between doctors and patients.
 
Results and Discussion: The results obtained in the research are presented throughout the text, mainly through examples, which will also reinforce the understanding of the topic and its relevance, since this subject is valuable for raising reflections on how such conflicts can be dealt with cooperatively, ensuring greater respect for the self-determination of those involved.
 
Research Implications: The research covers theoretical and practical contributions that can promote the application of mediation in the medical-hospital context, as a viable means of treating and resolving conflicts between doctors, patients and their families. The insertion of mediation in this environment seeks to create a more collaborative and humanized space, where the parties involved can dialogue in a transparent and respectful manner, with the objective of finding solutions that meet the interests of all, preserving both the rights of patients and the autonomy and responsibility of health professionals.
 
Originality/Value: The work provides relevant data for thinking critically and reflexively about the most appropriate methods for treating and resolving conflicts between doctors and patients, in order to contribute to the preservation of the patient's private autonomy, especially in cases of decision-making in ongoing health treatments.
The Legally of Agricultural Cooperatives in the State of Tocantins - Local and Regional Development
Authors: Mafra Neves Bigeli Beatriz Cilene , Aparecida de Araujo Querido Oliveira Edson , Prichoa De Marchi Liziane Fátima , Rodrigues Waldecy , De Melo Conti Diego , Capellani Quaresma Cristiano
Published: October 2024

Objective: this work seeks to explain what rural cooperativism is, what its systematics, legislation and meanings are. Also list the importance of rural cooperatives in the state of Tocantins and their main contributions to regional economic growth.
 
Theoretical benchmark: the regional development ends up becoming a topic that provokes many debates, as social evolution, dissatisfaction and non-conformity in the new society causes them to group together to train skills and abilities, with local, municipal and federal governments as parties. and states for the development process. In this sense, rural cooperativism assumes a leading role in the state of Tocantins.
 
Method: the method used in the study will be deductive as an exploratory analysis, qualitative approach, bibliographical and documentary analysis, with the search for understanding the theoretical framework aiming to conclude on the main issues relating to rural cooperatives in the state of Tocantins.
 
Results and conclusion: it was observed that cooperativism promotes and highlights the leading role of the Brazilian countryside in food production and generation of employment and income in the country. Cooperatives were pillars for the nationalization and commercialization of Brazilian agricultural products, leveraging production, modernizing the countryside, investing in new technologies, conquering the international market, thus reaffirming their importance for the country's economy. In this sense, agribusiness supported by agricultural cooperatives has been the fundamental element of the productive and economic sustainability of the state of Tocantins.
 
Implications of the research: the research offers new scientific contributions to the topic of rural cooperativism, offering theoretical bases for interventions and public policies that impact this economic activity in a Brazilian state, the state of Tocantins, with trends of strong economic and social growth.
 
Originality/value: discussions regarding social transformations in recent decades, related to the globalization of the economy, technology and its accessibility, have directly reflected in social life and consequently in work relations, thus the increase in regions relegated to oblivion, thus requiring, understand the meaning of the territorial approach to rural development through the implementation of active cooperativism that strengthens existing links in related production chains. Thus, new reflections, public planning and new investments are necessary and imperative elements in Brazilian states dedicated to agribusiness such as the state of Tocantins.
Transforming the Gardening Experience With Smart Garden Technology
Authors: Van Nieuwstadt Francesca , Rammal Jana
Published: October 2024

Smart garden systems are an innovative and emerging technology designed to revolutionize home gardening through the integration of advanced sensors and connectivity features, automating key gardening processes to ensure optimal plant growth with minimal intervention. With several new additions to these product lines launched within the last 24 months, these systems provide a novel approach to gardening, making it more accessible for users of all ages.
Comparación del pensamiento político de Occidente y Oriente – desde la perspectiva de la masculinidad-feminidad cultural
Authors: Xiaoyu Ruan
Published: October 2024

La cultura occidental y la oriental son diferentes en muchos aspectos. En este artículo, se argumenta que Occidente y Oriente tienen distintos ADN culturales a causa de la bifurcación de rumbos del desarrollo de ambas partes en la antigüedad. La diferencia en los ADN culturales determina el atributo de género de la cultura de ambos lados, es decir, Occidente ostenta una cultura masculina, mientras que Oriente, una cultura femenina, por lo que el pensamiento político occidental muestra un alto grado de masculinidad y el oriental presenta características de feminidad. Este artículo indagará los orígenes de los diferentes ADN culturales de Occidente y Oriente, analizará la formación de los diferentes rasgos culturales en dimensión de masculinidad-feminidad, y explorará específicamente la influencia de estos elementos en el pensamiento político, mediante la comparación entre el “poder duro” y el “poder blando”. Para terminar, concluiremos que las civilizaciones de Occidente y Oriente deberían complementarse en lugar de oponerse, y que ambas partes deberían aprenderse la una de la otro.
Reseña de libro: Cambios
Authors: Rosas Leyda
Published: October 2024

El escritor chino Guan Moye, o popularmente conocido como Mo Yan, ganador del Premio Nobel de Literatura en el año 2012, hace conocer a sus lectores en su breve novela “Cambios”, su autobiografía. A diferencia de sus otras obras con tintes históricos, que se desarrollan en la China del siglo XX: “Sorgo rojo”, “Grandes pechos, amplias caderas”, “Las baladas del ajo” o “La vida y la muerte me están desgastando”, donde los personajes son ficticios como; un clan familiar que cultiva sorgo, una valiente mujer con sus ocho hijas, cultivadores de ajo, o un rico terrateniente que muere y después reencarna en los animales de su granja; en este libro, los principales personajes son el mismo autor y sus amigos, quienes son personas reales, comunes y corrientes, que vivieron en carne propia, las primeras décadas del comunismo chino.
THE ROLE OF MAGNESIUM SUPPLEMENTS ON HYPERTENSION IN PREGNANCY AND PREECLAMPSIA
Authors: Nurwany Raissa , Ramadhina Shafira Fitri , Pariyana Pariyana
Published: October 2024

Objective:ThisÂ article aimsÂ to discuss the effects of magnesium supplementation on clinical outcomes of pregnancy and highlights the benefits of magnesium supplementation in reducing the risk of hypertension in pregnancy and preeclampsia.Â Method:Â In this systematic review article, the author conducted a literature search using certain keywords and selected articles that were published from 2013-2023, can be accessed in full-text in pdf format, and are in Indonesian or English. The methods used were in accordance with the reporting guidelines provided in the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P).Â Results:Â After carefully searching the database and eliminating articles that were not related to the topic, 6 articles were obtained for review. Hypertension in pregnancy and preeclampsia are serious health problems that can harm both mother and baby. Magnesium supplements have been studied as a way to reduce the risk of hypertension in pregnancy and preeclampsia.Â Conclusion:Â Magnesium supplements may help reduce the risk of hypertension in pregnancy and preeclampsia.
The Relationship of The Incident o Metabolic Syndrome and Overactive Bladder in Female Patients at DR. M. Djamil Padang in 2023
Authors: Anggra Pramana  , Utama Bobby Indra , Yetti Husna
Published: October 2024

Overactive Bladder (OAB) is a chronic medical condition that has a negative impact on an individual's health and quality of life. Cardiovascular problems are considered to be one of the risks associated with OAB where one of the higher cardiovascular parameters is metabolik syndrome.Â Aim to determine the relationship between Â metabolik syndrome and Overactive Bladder in female patients at Dr. M. Djamil Hospital Padang.Â Quantitative research with a case control design using a questionnaire according to the Overactive Bladder Symptom Score (OABSS) and examination based on metabolik syndrome symptoms. The research was conducted at Dr. M. Djamil Hospital Padang in November 2022 to September 2023.Â There were 60 respondents who were divided into the OAB (28/60) and no-OAB group (32/60). Most respondents were aged 50-59 years (45,0%), graduated from high school (53.3%), worked as housewives (76.7%) and had diabetes mellitus (78,3%). In this study it was also found that 48,3% of respondents suffered from hypertension and 45.0% suffered from obesity. A total of 46.7% of respondents experienced OAB symptoms with a higher percentage of OAB found in the metabolik syndrome group (76,7%) than no-metabolik syndrome group (16.7%). Bivariate analysis found a relationship between metabolik syndrome and overactive bladder symptoms (p = 0.000) with metabolik syndrome affected the incidence of overactive bladder by 16.4 times (OR 16.42, (CI 95% 4.56-59.07).Â There is a relationship between metabolik syndrome and the incidence of OAB.
Comparison of Microbiota in Threatened Preterm Labor and Normal Pregnancy at RSUP DR.M. Djamil Padang
Authors: Ryfki SA Muhammad , Yanti Roza Sri , Utama Bobby Indra
Published: October 2024

One of the threats in pregnancy is threatened preterm labor. Several studies show that the composition of the microbiota in the vagina of premature births and normal pregnancies is different. This study aims to determine the comparison of microbiota in pregnancies with premature parturition and normal pregnancies at Dr M Djamil General Hospital, Padang. This research is an analytical observational study with a case–control study design conducted at the Department/SMF of Obstetrics and Gynecology, RSUP Dr. M. Djamil Padang from July – September 2023. The study population in this research were all pregnant women with a gestational age of 20-37 weeks who were diagnosed with imminens preterm labor and normal pregnant women with a gestational age of 20-37 weeks who received antenatal care at RSUP Dr. M. Djamil Padang. Respondents had vaginal swabs taken for microbiological culture at the Biomedical Laboratory, Andalas University, Padang. There were 33 respondents each in the imminence premature birth and normal pregnancy groups. Vaginal swab results showed that the most common microorganism found in normal pregnancy was Lactobacilus sp. (73%) while in threatened preterm labor Staphylococcus aureus (37%), Staphylococcus epidermidis (27%) and E.coli (15%) were more commonly found with only a small proportion of Lactobacilus sp (12%). Chi square analysis showed a significant difference between the vaginal microbiota of normal pregnant women and pregnant women with PPI. The conclusion of this study is that there is an increase in Staphylococcus aureus, Staphylococcus epidermidis and E.coli in pregnant women on PPI with a decrease in the number of normal flora, namely Lactobacilus spp.
Relationship between Serum Magnesium Status and the Incidence of Preeclampsia at 8 Padang Primary Health Care
Authors: Fajriati Hifzhillah , Utama Bobby Indra , Nurhayati Nurhayati
Published: October 2024

Introduction: Preeclampsia is one of the main causes of maternal morbidity and mortality, with its etiology and pathophysiology not fully understood. Several studies have shown that magnesium plays an important role in preeclampsia. Magnesium plays a role in modulating endothelial function. Decreased serum magnesium levels in pregnancy can trigger endothelial dysfunction that has an impact on the occurrence of preeclampsia.Objective: Determine the relationship between serum magnesium status with incidence of preeclampsia in pregnant women at 8 Padang Primary Health Care.Method: An observational analytic with cross-sectional design. Sampling was carried out using total sampling technique from research master data at 8 Padang Primary Health Care for period June 2019 â€“ May 2020. The total sample was 45 pregnant women who met the inclusion and exclusion criteria. Data were analyzed using Fisherâ€™s.Result: The serum magnesium status of pregnant women in the 8 Padang Primary Health Care was dominated by normal serum magnesium status (91.1%) and only 8.9% of pregnant women had preeclampsia. Fisherâ€™s test showed that there was a significant relationship between serum magnesium status and the incidence of preeclampsia (p-value = 0,034).Conclusion: There is a significant relationship between serum magnesium status and preeclampsia (with overlook the factors of previous preeclampsia history, family history of preeclampsia, and magnesium intake during pregnancy). Hypomagnesemia status in pregnant women can exacerbate the occurrence of preeclampsia.
Management of Hyperprolactinemia Caused by Pituitary Microadenoma
Authors: Muttaqin Ibnu , Yuad Haviz
Published: October 2024

Hyperprolactinemia is an increase in fasting levels of the hormone prolactin above 20 ng/ml in men and above 25 ng/ml in women. Hyperprolactinemia occurs more often in women of reproductive age, with a percentage of 9 â€“ 17%. The etiology of hyperprolactinemia can occur due to abnormal pituitary secretions, systemic disease, use of drugs, damage to the hypothalamus-pituitary axis. A 33-year old female patient came to the FER Polyclinic at M. Djamil Hospital with complaints of not menstruating for the past 2 months. Irregular menstruation since 15 years ago, menstruation 2-3 times in 6 months, irregular cycle for 7-8 days. The patient also complained of a fluid like breast milk coming out of the breast for 5 years, initially the fluid came out in a trickle and then gradually reduced and now the fluid comes out occasionally if the breast is squeezed. From the supporting examinations carried out, it was found that the prolactin hormone level in this patient was 134.53, and the results of the MRI examination showed a mass measuring 1.05x1.12x0.5 mm, which was diagnosed as secondary amenorrhea, hyperprolactinemia, and suspected pituitary microadenoma. The patient will be monitored for general condition and vital signs, as well as consultations with colleagues involved, such as consultations to the Internal Medicine section, Endocrinology, Metabolic and Diabetes Subdivision.
A Investigation of Bad Credit in P2P Lending Based on Personal Character in Indonesia
Authors: Famela Febby , Apriliyant Rizky Suci
Published: October 2024

This research examines Indonesian P2P lending and bad loan management by analyzing borrower characteristics. The large value of problematic loans is a key signal for this investigation. The Big Five Personality Approach is used to survey P2P lending users. This study solely examines if the Big Five personality traits affect evaluation. On March 5–18, 2023, 17 P2P lending sites gathered data from 197 respondents for two weeks. Data validation continued until 11 respondents were pruned. The remaining 186 respondents' data was evaluated using SPSS. The management process yielded two hypothesis tests, the T-test and the F-test, which showed that the Big Five personality significantly affects present assessment activities. F-Test findings show the Big Five Personalities have a big impact concurrently. These two factors suggest that the Big Five Personalities may evaluate decision support systems for borrower recommendations.
Design of Study Program Performance Dashboard using Streamlit
Authors: Ilham Moch Ilham A , Siswanto Teddy , Sugiarto Dedy
Published: October 2024

To achieve certain performance goals, such as increasing the integration of study program performance data from various sources, such as student data, lecturers, curriculum, research, and so on, a performance dashboard is needed to monitor the performance of lecturers, students and curriculum to be more efficient. In this study, a dashboard was created with streamlit where the data was taken from the web scraping method. By utilizing the data visualization capabilities owned by Streamlit, study program performance information can be presented in the form of graphs, diagrams, or tables that are easier to understand and interpret.
Dispositifs pulsionnels et économies de la subjectivation : actualités de Nietzsche au prisme de Pierre Klossowski
Authors: Vaillancourt Thibaut
Published: October 2024

This article aims to reposition Nietzsche's thought within contemporary fields of research through the prism of its reception by Pierre Klossowski. Our analysis makes use of Klossowski's unpublished manuscripts, allowing us to better articulate and situate Nietzsche's thought within Klossowski's thought, which is nourished by a dialogue that goes beyond his work devoted to Nietzsche and develops an analysis that is particularly amenable to updating. In developing a Nietzsche-informed general economy of subjectivation, Klossowskian theory tends toward various aspects of theoretical explorations present in media thought and the posthumanities. In doing so, we show that Nietzsche's thought, as approached by Klossowski, allows for unprecedented connections that shed light on the genealogy of the posthumanities, conceptually enrich research in Media archaeology and Science and Technology Studies, and anticipate the crucial role of affect and information in contemporary processes of subjectivation.
Blood on the Leaves / Blood on the Roots
Authors: Brown Brendan
Published: October 2024

This paper sets out to investigate the Nietzschean connection between Sylvia Wynter and Reiner Schürmann through a reading of Nietzsche’s On the Genealogy of Morals. Nietzsche’s account of ‘bad conscience’ is read through the Wynterian and Fanonian concept of ‘sociogeny’ to demonstrate its necessity to Nietzsche’s project of the Great Redeemer. This paper, then, demonstrates a previously undiagnosed influence of Nietzsche on Wynter and the role that anarchy plays in her construction of the ‘human being as praxis’. The essay concludes with an amelioration of Schürmann’s epochal genealogy to account for a racialized lacunae present in his Western genealogy of thought. It is by bringing all three together that we understand anarchy as being firmly committed to anti-racist and anti-anti-Black enactments. It concludes by highlighting the possibility of metaphysics after the withering of epochal archē in what this paper calls ‘the multitude of metaphysics’.
The Importance of Being Honest: Free Spirits and Idiosyncrasy in Nietzsche
Authors: Stevens Zachary
Published: October 2024

The main argument of this paper is that the debate on whether Nietzsche is communitarian or individualist is wrongheaded, failing to distinguish the conception of community and individual Nietzsche critiques, the 'mob' and the 'Higher Man', from the conceptions Nietzsche envisions and hopes for, his 'free spirits' and – what I call, based on the critique of indivisible subjects in the Genealogy of Morality – the idiosyncrasy. I propose a reading of Nietzsche which elaborates his novel conception of a non-ascetic will to truth, based in courageous honesty and self-overcoming, rather than self-preservation, in order to conceive these individuals and communities. The coupling of Dionysus and Apollo has to be replaced with Dionysus and Ariadne because, using key terms from Deleuze's Nietzsche, the sense and value of critique is generated from a labyrinthine, Dionysian meaning as will to power and Ariadne's thread as evaluation based on the eternal recurrence, constituting the idiosyncrasy and the free spirits, respectively.
Nephrology in Andhra Pradesh
Authors: Tatapudi Ravi Raju , Gullipalli Prasad , Menon P J Gopika
Published: October 2024

Nephrology emerged as a specialty in Andhra Pradesh during the 1970s and rapidly developed into a well-defined field by the 1990s. Key academic institutions like Osmania and Andhra Medical Colleges laid the groundwork for kidney care in the state. Autonomous institutes like NIMS and SVIMS became centers of excellence, complemented by the swift expansion of private hospitals offering high-quality care. The introduction of Rajiv Aarogyasri in 2007 revolutionized access to treatment for end-stage kidney disease patients through free hemodialysis in government hospitals. The Jeevandan initiative, started in 2010, centralized deceased donor organ allocation, leading Andhra Pradesh and Telangana to achieve the highest number of organ transplants in India. Training programs in nephrology are now producing skilled specialists nationwide. Despite ongoing challenges like Uddanam Nephropathy, initiatives such as government-provided RO water may improve public health, contributing to Sustainable Development Goals on health and sanitation. The state has made significant strides in kidney disease care and academic nephrology.
Calciphylaxis Induced Isolated Bowel Gangrene in a Septic Deceased Donor Renal Transplant Recipient
Authors: Gysley Belmin B J Winston , Singh Sarbpreet , Bamaniya Bharat Bhushan , Sethi Jasmine , Patil Shiva Kumar S , Kenwar Deepesh B , Sharma Ashish , Tirkey Abhilash Bipin Kumar , Nada Ritambhra , Sekar Aravind , Iangngap Elgiva Khristie
Published: October 2024

Calciphylaxis is a rare and life-threatening condition caused by the buildup of calcium in the small blood vessels. It usually affects the deep layers of the skin and tissues in areas such as the abdomen and lower limbs, but can also affect internal organs like the intestines, causing symptoms like gastrointestinal bleeding and bowel tissue death. We encountered a case of calciphylaxis affecting the blood vessels in the intestines of a chronic kidney disease patient who had received a deceased donor kidney transplant. Unfortunately, the diagnosis was delayed, leading to a fatal outcome. This case underscores the importance of considering visceral calciphylaxis in high-risk patients, even when there are no outward signs on the skin.
Comparative Analysis of Intraoperative Nerve Monitoring (IoNM) with Conventional Thyroidectomy: A 10-Case Study
Authors: Palled Kavitha Prakash
Published: October 2024

Objectives:

To evaluate the effectiveness of intraoperative nerve monitoring (IoNM) in reducing recurrent laryngeal nerve (RLN) injury and improving surgical outcomes compared to conventional thyroidectomy.

Material and Methods:

This study at BGS Apollo Hospital, Mysore, included 20 patients (ten with IoNM, ten conventional) from January to July 2023. Outcomes assessed were RLN injury, hypocalcemia, operative time, hospital stay, and vocal cord function.

Results:

RLN Injury: IoNM group had 10% temporary RLN injuries and no permanent injuries, versus 30% temporary and 10% permanent injuries in the conventional group.

Hypocalcemia: Transient hypocalcemia occurred in 20% of the IoNM group and 40% of the conventional group.

Operative Time and Hospital Stay: IoNM cases had a slightly longer operative time (110 min) but shorter hospital stay (2.2 days) compared to the conventional group (95 min and 3.1 days).

Vocal Cord Function: IoNM group showed minimal voice changes and normal vocal cord mobility, while 40% of the conventional group experienced significant voice issues.

Conclusion: IoNM significantly reduces RLN injury and improves recovery, despite a minor increase in operative time. IoNM is recommended for enhancing outcomes in thyroid surgery.
Features of environments for cage fish farming in the Astrakhan Region on example of the Khurdun River
Authors: Pyatikopova O. V. , Bedritskaya I. N. , Diakova S. A. , Popov D. A. , Tarasova O. G. , Makarova E. V. , Minakova E. V. , Zhatkina O. V. , Kashin R. D.
Published: October 2024

Cage aquaculture is a relatively low-cost and quite effective method of fish farming, particularly important for the Astrakhan Region in recent times. Sturgeon species are grown in the farms there mainly. The most favorable conditions for cage aquaculture are provided in flowing water of both natural and anthropogenic nature. Features of environments for cage fish farming are considered for several operating fish farms at the Khurdun River that is rather demanded for these enterprises due to accessibility to roads, proximity of settlements and so suitability for the farm servicing and selling the products. However, the river is rather impacted to anthropogenic activity, including pollutions from the fish farming itself. Standard methods of hydrology, chemistry and biology were used. The fish farms at Khurdun River were differed in their production capacity and the volume of aquaculture production, though the depth of the cage lines installation was sufficient for the fish growing everywhere. The flow velocity was rather slow and decreased at cages of the most farms relative to the background value. Dissolved oxygen content in water was quite high, but great vertical differences were observed in summer, with supersaturation at the water surface and oxygen consumption for oxidation of organics at the river bottom. The value of chemical oxygen consumption exceeded the norm both at the surface and at the bottom and increased downstream. By taxonomic composition of bioindicator benthic organisms, the studied water body was classified to categories from “clean” to “very dirty”. Some deterioration of environmental quality downstream from the cage lines was detected relative to background values. Sanitary and microbiological tests of water revealed an exceeding of the total microbial count at 22 o С relative to this one at 37 o С in all seasons, that is a sign of water self-purification worsening. Faecal pollution of the river water was found and confirmed by a presence of Enterococcus faecalis in abnormal concentration, in particular in summer-autumn low-water season. In general, environmental conditions in some sites of the Khurdun River can be considered as tense in the summer-fall season by a number of parameters. Deterioration of environmental regime in conditions of rising temperature and slowing flow in the summer-fall low-water season should be accounted for adjustment of planting density and feeding of farmed fish.
Trophological calendar for salmon in the Okhotsk Sea
Authors: Volkov A. F.
Published: October 2024

Feeding habits of salmon are examined on the data from “Trophology” and “Zooplankton” databases for 1988–2023, taking into account calendar dates and spatial localiza tion of the salmon size classes. The dominant zooplankton species and groups in salmon food are defined and their availability in terms of time and depth of habitat is determined. Daily rhythm of salmon feeding is found uniform for all size groups. The areas and time (months) of maximum concentrations of salmon are determined, by size groups, and those ones are considered as the areas and periods of their most active consumption. A trophological calendar is constructed to show where, when, and what type of food is consumed by certain species and size group of salmon. Daily food rations are calculated for all salmon species and size groups. The rations are similar with those in the Bering Sea, with small differences possibly caused by different structure of the plankton communities. The application tables are compiled for operational calculations of total food consumption by size groups of salmon species with a predominant zooplankton prey (pink, chum and sockeye). According to the forecast published at VNIRO website vniro.ru, the salmon catch in the Far Eastern basin will decrease by more than 2 times in 2024, primarily due to pink salmon. In this case, significant reduction in salmon pressure on plankton community can be expected.
Experience of implementation and approaches for further automation in unmanned aerial counting of pacific salmon in the Okhotsk district of Khabarovsk Region
Authors: Kotsyuk D. V. , Sviridov V. V. , Povarov A. Yu.
Published: October 2024

Unmanned aerial counting of pacific salmon in the rivers of the Okhotsk district (Khabarovsk Region) in 2021–2023 is analyzed. Estimates of the spawning redds number and the spawners abundance are presented for the monitoring sites. Prospects for using these indices for forecasting the stocks are discussed. Specifics of unmanned counting are considered, and options for further development of the methodology are proposed. The method of unmanned counting is suitable for information support of the stock forecasts only, but can be modified for application in fishery management and spawning grounds inventory. Possibilities for further automation in the unmanned counting of pacific salmon are considered on the base of the authors’ experience and literature information. Proposed approaches to automation are outlined for key stages of unmanned counting, as spatial coverage planning, aerial photography acquisition, photogrammetric processing, vectorization, and abundance estimation. Features of the automation implementation depend on purposes of the counting and are different for the stock forecasting, fishery management, and spawning grounds inventory. Adequate automation should be based on ensuring consistency and mutual balance of approaches used at different stages of the counting.
The green synthesis of Zinc Oxide nanoparticles utilizing Camellia Sinensis var. Assamica found in commercial tea dust, and their broad spectrum antibacterial activity
Authors: Lahoti Ronith , Carroll Dusty
Published: October 2024

The antibacterial activity of biosynthesized Zinc Oxide (ZnO) nanofluid was investigated against three gram-positive bacteria (Enterococcus faecalis, Methicillin-resistant Staphylococcus aureus, Staphylococcus saprophyticus) and two gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). Tea dust, obtained from “Lipton® black tea decaffeinated” tea bags, and distilled water was used to prepare an extract; with zinc acetate and sodium hydroxide as precursors to synthesize the ZnO nanoparticles, the extract was used as a reducing agent. ZnO nanoparticles were synthesized using a green method involving tea extract and characterized by EDX, TEM, and UV-VIS spectroscopy, revealing particles between 40–60 nm, with some particles as small as 18 nm, and the nanoparticles exhibited an agglomerated, sponge-like asymmetrical shape and maximum absorption at 380 nm. Despite its performance being slightly lower than standard antibiotics like Ciprofloxacin, Meropenem and Vancomycin, the ZnO nano-fluid still demonstrated significant antibacterial activity.
Structure-switching DNA templates for the rational and predictable control of cell-free transcription
Authors: Urosevic Ana , Federico Iacovelli , Ercolani Gianfranco , Idili Andrea , Ricci Francesco
Published: October 2024

We report here a strategy to control cell-free in vitro transcription of RNA by the rational design of synthetic structure-switching DNA templates. These templates are programmed to undergo a conformational change between an open (OFF) and a closed (ON) state. By controlling the switching equilibrium constant (KS) of such structure-switching templates, we can finely program their transcription efficiency. We have derived a simplified kinetic model that describes our experimental data with high accuracy, supporting the predictability of our approach. Similarly, we have also performed different molecular dynamic simulations that provide an atomistic description of our results. Finally, the introduction of such a conformational change mechanism in target-responsive templates allows rational control of their dynamic range (i.e., the range of target concentration to which they respond) and of their input-output behavior. The structure-switching templates demonstrated in this work are particularly easy to design and provide a highly programmable approach to control cell-free transcription, a feature that can be of great utility in fields like sensing and RNA therapeutics.
Robust Automated Equilibration Detection for Molecular Simulations
Authors: Clark Finlay , Cole Daniel , Michel Julien
Published: October 2024

Quantities calculated from molecular simulations are often subject to an initial bias due to unrepresentative starting configurations. Initial data are usually discarded to reduce bias. Chodera's method for automated truncation point selection [J. Chem. Theory Comput. 2016, 12, 4, 1799–1805] is popular but has not been thoroughly assessed. We reformulate White’s marginal standard error rule to provide a spectrum of truncation point selection heuristics that differ in their treatment of autocorrelation. These include a method effectively equivalent to Chodera's. We test these methods on ensembles of synthetic time series modelled on free energy change estimates from long absolute binding free energy calculations. Methods that more thoroughly account for autocorrelation often show late and variable truncation times, while methods that less thoroughly account for autocorrelation often show early truncation, relative to the optimal truncation point. This increases variance and bias, respectively. We recommend a method that achieves robust performance across our test sets by balancing these two extremes. This, and all other heuristics tested, are implemented in the open-source Python package RED (github.com/fjclark/red).
Evaluation of the results of magnetic resonance imaging of the brain for cognitive impairment in patients with heart failure: A review
Authors: Shariya Merab A. , Ustyuzhanin Dmitry V. , Zhirov Igor V. , Osmolovskaya Yulia F. , Tereshchenko Sergey N.
Published: October 2024

Cognitive impairment is a very common comorbidity in patients with heart failure (HF). Patients with HF show signs of memory decline, difficulty concentrating, and attention deficits. Cognitive dysfunction in HF is associated with a poor prognosis. However, the diagnosis of cognitive impairment in heart failure has received insufficient attention in routine clinical practice. Neuropsychological screening tests are available to screen for cognitive impairment, but they are used infrequently. Therefore, it is of practical interest to search for magnetic resonance equivalents of cognitive disorders. The use of magnetic resonance imaging as a tool for identifying and quantifying neural correlates of cognitive functions is discussed.
Long-term goflkicept therapy for patients with idiopathic recurrent pericarditis: results of the interim analysis of an ongoing open-label extension study
Authors: Myachikova Valentina Yu. , Maslyanskiy Alexey L. , Moiseeva Olga M. , Schedrova Margarita L. , Egorova Alina N. , Ponomar Еkaterina G. , Samsonov Mikhail Yu.
Published: October 2024

Aim. To evaluate the long-term safety and efficacy of goflkicept treatment in patients with idiopathic recurrent pericarditis (IRP).
Materials and methods. This report presents the interim analysis of an ongoing open-label extension (OLE) clinical trial of goflkicept in patients with IRP (NCT 05673902), as a continuation of the core study (NCT04692766). The study assessed the frequency of pericarditis recurrence, time to recurrence after 12 and 60 weeks of goflkicept therapy, changes in C-reactive protein level, chest pain intensity, pericardial effusion size, and adverse events (AEs).
Results. All patients remained in clinical-laboratory remission during the 60 weeks of goflkicept treatment. The recurrence frequency was 31.3% (5/16) after 60 weeks and 90% (9/10) after 12 weeks of goflkicept treatment (p0.001). A total of 64 AEs were reported in 16 patients (94.1%), mostly of mild to moderate severity. The most common AEs were infections, occurring in 11 patients (64.7%). Nine serious adverse events were reported in 5 patients, none of which were considered drug-related. There were no deaths.
Conclusion. Long-term goflkicept therapy resulted in a significant reduction in the risk of recurrence and prolonged remission without an increase in adverse events.
Correlates of Sexual Dysfunction in Male Patients with Alcohol Dependence Syndrome: A Cross-Sectional Study
Authors: Dhuruvasan Dr. Saritha , Sumithradevi Dr. , Usaid Dr. , Gayathri Dr. Uma , Ilango Dr. Siva
Published: October 2024

Introduction: Sexual dysfunction and alcohol dependence syndrome are complex issues that significantly impact the overall well-being and quality of life of affected individuals. Sexual dysfunction, encompassing various issues such as erectile dysfunction, reduced libido, and orgasmic disorders, is a prevalent concern affecting a substantial proportion of the male population worldwide. Aim: To estimate prevalence of sexual dysfunction in patients admitted for Alcohol dependence and to identify various Clinical and Socio demographic correlates for sexual dysfunction in this population. Materials and Methods: The study involved fifty-eight male participants who had sought deaddiction treatment at the Psychiatry Outpatient Department of Tertiary Care Centre, Maduranthakam for alcohol dependence syndrome, diagnosed according to the ICD‑10. Information on sociodemographic, alcohol-related, and sexual dysfunction-related variables was gathered. Sexual dysfunction was assessed for the past year, ignoring temporary and situational complaints. The relationship between sexual dysfunction and various study variables was explored using relevant statistical tools. Results: Out of the total sample size evaluated using SAD-Q score, 71% are moderately dependent and 29 % are severely dependent. Sexual Dysfunction was present for 64% of patients in the study. For the 58 patients in the study, the most common sexual dysfunction reported was an absence of sexual desire in 19 patients, followed by erectile dysfunction which was present in 18 patients. The ability to reach orgasm was difficult for 6 patients. Satisfaction from orgasm was absent for 4 patients. Conclusion: This research seeks to advance our understanding of sexual dysfunction in male patients with alcohol dependence syndrome by unravelling the intricate web of factors influencing their sexual health.
Prevalence of GERD among adult asthmatics visiting a tertiary care hospital
Authors: M Saravana Ethinder
Published: October 2024

Asthma and its control is influenced by both external environmental factors and also on the presence of several comorbid conditions like allergic rhinitis, gastro esophageal reflux disease(GERD), obesity etc. We aim to study the prevalence of GERD in adult asthmatic patients visiting a tertiary care hospital. We conducted a period prevalence survey of adult asthmatics visiting the outpatient department. Gastro esophageal reflux disease was diagnosed clinically through GERD-Q questionnaire. The study was conducted at Sri Venkateswaraa Medical College and Hospital and Research Institute, Chennai. A total of 110 patients were taken for the study. GERD was prevalent among 50% of the study population. 86.2% of the smokers in the study were having GERD. Mean Body Mass Index(BMI) in the study population was 29.14 +/- 4.8 with 72.7% of the patients with gastro esophageal disease were overweight in their body mass index. Significant number of patients with asthma are known to suffer from GERD. GERD worsens the symptoms in asthma and makes it difficult to control with regular inhalational therapy. Being overweight in BMI, smoking are risk factors to the development of gastro esophageal disease and also influence lung function in asthma patients. Symptoms for GERD must be questioned to treat the disease and adequately control asthma.