bluuebunny/crossref_metadata_2025 huggingface dataset:
Morin mitigates Chronic and Unpredictable Mild Stress-Induced Depression by Regulation of Endoplasmic Reticulum Stress and Brain-Derived Neurotrophic Factor-Mediated Apoptosis
Authors: Thenmozhi Arokiasamy Justin
Published: April 2022

According to the report of World Health Organization, it is expected that depression will be one of the major causes for disability and disease in the world, by 2030. Currently used drugs will not be effective to the depressive patients, due to their lower efficiency with side effects. Hence, there is a need to concentrate on natural products to overcome therapeutic hassles. Morin, a bioflavonoid found in fruits, vegetables, some herbs and wine is reported to have an antidepressant-like effect against acute stress conditions. It is reported to possess various pharmacological properties such as antioxidant, anti-diabetic, hepatoprotective, anti-cancer and anti-inflammatory activities. To understand the antidepressant effect of morin against unpredicted chronic mild stress (UCMS), rats were divided into normal, UCMS alone, UCMS and morin (30 & 60 mg/kg) and morin alone (60 mg/kg) groups. Serum corticosterone levels, expression of brain derived neurotrophic factor (BDNF), apoptotic and endoplasmic reticulum (ER) stress related indices were compared among the groups. UCMS alone exposed rats showed less crossings with diminished activities in open field test (OFT), increased serum corticosterone levels and enhanced expression of BDNF signaling and ER stress related markers associated with apoptosis as compared to control. In contrast, morin (60 mg/kg b.w.) cotreatment attenuated UCMS induced abnormalities as compared to UCMS alone exposed animals. The present results indicated the antidepressant-like actions of morin against UCMS in rats were partially due to its anti-apoptotic effects by regulating BDNF/Trk-B and ER stress related markers. Moreover the results of the present study indicated that the morin may act as therapeutic agent for the management of depression alone or with other currently used antidepressants.
Use of Color Channels to Extract Heart Beat Rate Remotely from Videos
Authors: Sinhal R. A.
Published: April 2022

Since last decades, photoplythesmography (PPG) signals that are extracted from the optical absorption in the tissues are increasingly being used for health diagnosis. Despite a good literature, there are different claims about the use of color channels as red, green and blue for extraction of PPG signal, i.e., pulse rate from the videos captured through high resolution cameras. In this article, we present the technique for extracting the heart beat rate (pulse rate) from the videos captured through the mobile cameras for all three color channels and thier analysis. Experiments were performed on a DMIMS database comprising 720 videos, out of which we used 25 videos for the analysis. The pulse rate estimated from the blue channel, was in good agreement with reference data extracted using an MP20 monitor, used as the gold standard. The findings of the present study demonstrated the non-invasive color intensity method for detection of pulse rate from the pre-recorded video of 30 seconds. The algorithm is tested on the DMIMS dataset which we have captured in uncontrolled setting. The green channel is proven to be statistically significant for the video recorded followed by red and then blue channel. The accuracy of the pulse extracted is still low because of low signal to noise ratio.We therefore conclude that the presented technique is best for pulse rate extraction through a blue channel followed by red and green channels respectively.
Role of Senna, Cassia angustifolia and Fennel, Foeniculum vulgare in Ameliorating Nephropathy in Diabetic Rats
Authors: Osman Nadia Nour
Published: April 2022

Diabetes mellitus is one of the most challenging metabolic pandemics that affect essential biochemical pathways in the body. The cost of Diabetes mellitus treatment and its side effects may call for an investigation on plant products as sources of treatment. Whereas, traditional medicine has proven that treatment with plant extracts is affordable, effective, and may have fewer negative effects than modern medicines. The current study aimed to investigate the renoprotective effects of senna (Cassia angustifolia) and fennel (Feoniculum vulgar) against streptozotocin-induced diabetes in albino rats. Male albino rats were used as animal models which divided into five groups, normal group (control), diabetic group (single i.p. 60 mg/kg of streptozotocin, (STZ), and 3 diabetic groups that were treated with aqueous extract of (senna (150mg/kg/day), or fennel (150mg/kg/day) and their combination) by gastric intubation for 4 weeks. Diabetic rats exhibited a highly significant increase in the levels of blood glucose, renal enzymes and renal weight. Also, a significant increase in nitric oxide (NO), thiobarbituricacid reactive substances (TBARS) and xanthine oxidase (XO) accompanied by a significant decrease in vitamin C, catalase (CAT) and reduced glutathione (GSH) in renal tissues as compared to control group. In conclusion oral administration of senna and/or fennel extract reduces oxidative stress in renal tissue by lowering blood glucose levels, increasing plasma insulin, and restoring weight loss and levels of renal enzymes in diabetic rats. The present investigation suggested that the treatment with mix of (senna and fennel) exhibited antidiabetic activity, and had renoprotective effects in streptozotocin-induced diabetes rats.
Production of Total Reducing Sugars from Bambusa balcooa through Oxalic Acid Pretreatment
Authors: Sivamani S.
Published: April 2022

This study aims to assess the applicability of organic acid pretreatment on culm of Bambusa balcooa for the production of maximum total reducing sugars. The experiments were performed by varying organic acids (Formic, acetic, pyruvic, maleic, malic, tartaric, adipic, citric and oxalic acids), concentration of oxalic acid (1-4% (w/v)), solvent to solid ratio (5-40 mL/g), pretreatment time (0-60 min) and temperature (75-135 0C) to maximize total reducing sugars (TRS) concentration using fractional factorial design based one-factor-at-a-time (OFAT) approach. Total reducing sugars concentration was estimated by using 3,5-dinitro salicylic acid (DNSA) method. Among various organic acids, oxalic acid exhibited higher reducing sugars concentration. The optimal values show that the maximum TRS of 48.33 g/L was achieved at oxalic acid concentration, solvent to solid ratio, time and temperature of 3% (w/v), 10 mL/g, 15 min and 121 0C for the pretreatment of cassava stem with oxalic acid. A low value of coefficient of variation (CV = 0.32%) showed that the optimal conditions were validated by experiments. Thus, B. balcooa could be used as a potential feedstock for the production of TRS by organic acid pretreatment.
Feeding Behavior of Blackbuck, Chinkara and Spotted Deer in Captivity at Lal Sohanra National Park Bahawalpur, Pakistan
Authors: Hussain Saddam
Published: April 2022

Lal Suhanra National Park is one of the important protected areas of Pakistan. From many years endangered species of deer are being raised in captivity at Lal Suhanra National Park. In this study, we have observed the blackbuck, chinkara and spotted deer which are highly endangered. The the findings of study showed that blackbuck, chinkara and spotted deer eat daily any of the seasonal grasses like e.g., Maize (Zea mays), Jantar (Sesbania bisbinosa), Berseem (Trifolium alexandrinum) Bajra (Pennsietum glaucum) 4 to 6 kg, 3-5 kg and 4-5 kg respectively. Softened parts of the plants were also being eaten, which included Jandi (Prosopis spicigera), Kikar (Acacia sp.), Sheesham (Dalbergia sissoo), Lamb (Aristida depressa), Gorkha (Lasiurus hirsutus), Khawai (Cymbopogon jawarancusa), Murat (Panicum antidotale), Dhaman (Cenchrus pennisetiformis), Lana (Haloxylon recurvum), Ber (Zyziphus sp.), Katran (Cymbopogon martinii), Khiri (Euphorbia prostrata), Khip (Leptadenia pyrotechnica), Chag (Crotalaria burhia), Dele (Capparis decidua), Phel (Neslia sp.), Ghandeel (Eleusine flagillifera), Ak (Callotropis sp.) and Jal (Salvadora oleoides). While the all showed the similar amount of parched channa consumption. Softened plant parts of various species were also being given in their feeding. It is concluded that these species can live on the variety of fodders where the deer eat little amount of grass in a single day for survival as compared to other fodder types.
Conventional Medicinal Uses and Chemical Structure of Important Secondary Metabolites in the Genus Eremostachys: A Literature Review
Authors: Khan Amrendra M
Published: April 2022

Genus Eremostachys Bunge is a key medicinal plant grown in Eastern Europe, Central and Western Asia and Middle East. The plants of this genus have numerous secondary metabolites, which exhibit both traditional and pharmacological applications. Eremostachys contains several classes of reactive chemical ingredients such as flavonoids (viz. Apigenin, Luteolin, Loasifolin, Loasin A, Apuleisin, Apigenin and Kaempferol etc), isoflavonoids (viz. Soforanarin B, Loasin B and Vicarin), iridoid glucosides (viz. Shanzhiside, Lamalbide, Lamalbidic acid, Epiloganin, Pulchelloside, Harpagide, Pulchelloside, hamighriprasin, Eremoside, Phloyoside and Barlerin etc.), phenylethanoid glycosides (viz. Verbascoside, Leucosceptoside A, and Echinacoside etc,), acids, hydrocarbons, terpenes, diterpenoids and sterols (viz. Eremostachiin, Phlomisoside II, Stigmasterol, β-Sitosterol, Daucosterol and Oleanolic aicd) etc. These metabolites are well known for their pharmacological applications such as antibacterial, anti-inflammatory, antioxidant, antirheumatic, anti-poisonous, antimalarial, anticancer, antimalarial, antiallergic, antiarthritic and antidepressant etc. Before the identification of chemical constituents, genus Eremostachys was used by few countries since ancient viz. by China, Iran, India, Pakistan, Tajakistan and few middle and south Asian countries etc. This genus has been used by people of these region since ancient as analgesic, anti-inflammatory, wound healing, ant-insecticidal, antiparasitic, antiallergic, liver care, joint pain, arthritis, antioxidant, antibacterial, antidepressant, antimalarial, perfumery, detergent, soap, beauty products. In India, E. superba has been used as a food for cattle to increase milk production. In the present review, the important traditional uses of some important species of the genus Eremostachys have been briefly discussed due to their availability and affordability. The number of medicinal and pharmacological applications of the plant genus Eremostachys are also summarized in the paper.
Emergency Department Revisit Rate of Chronic Obstructive Pulmonary Disease Patients On Oral Corticosteroids: An Observational Study
Authors: Ismaeil Taha
Published: April 2022

Studies report inconclusive results regarding the efficacy of oral corticosteroids to reduce the risk of re-visiting the Emergency Department (ED). The aim of this study was to compare COPD patients who received oral corticosteroids and got re -admitted to the ED earlier than 60 days. An observational study was conducted at the ED from 2016 to 2018. A cohort of adult COPD patients, who received oral corticosteroids was assessed for any ED re-visit due to a COPD exacerbation. A total of 325 COPD patients included the study, 71% had no subsequent ED visit, and 94 (28%) patients had a repeat ED visit due to a COPD exacerbation. Of this ED re-visit group, 61% was within 60 days. The ED re-visit within 60 days group was more likely to have cardiovascular disease than the group with an ED re-visit after 60 days (51% vs. 45%, p-value 0.64).The use of oral corticosteroids could potentially reduce the severity of COPD exacerbation and ED re-visits.
Focus Group Discussion (FGD) in adopting Malaysian Sign Language (MySL) as a Third Language among Typical Children and Adolescents
Authors: Tengku Jamaluddin Tengku Zetty Maztura , Saidin Norshiha , Broome Emma , Tengku Jamaluddin Tengku Intan Baizura
Published: April 2022

Children with early-onset, severe to profound deafness are more vulnerable to mental health problems than their hearing peers. Communication deprivation is a key risk factor in developmental delays. The key element of the Introduction to MySL pro forma is to create awareness and assess the willingness to adopt a new language among hearing individuals prior to embarking on inclusive education. The objectives of this paper are to explore youths and adolescents’ prior experience and attitudes communicating with persons with hearing difficulties (PWHD), MySL lesson expectations, and adolescents' experience of the MySL pro forma and their attitudes towards communicating with PWHD.
Keywords: inclusive communication; Malaysian Sign Language; third language; adolescents
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians), and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i19.3183
Office Rent Prediction based on the Influenced Features
Authors: Mohd Thuraiya , Harussani Muhamad , Masrom Suraya , Johari Noraini , Alfat Lathifah
Published: April 2022

This study applies a new approach in identifying the best Machine Learning model to predict office rent and determining the most significant factors influencing rental values. The Auto Model uses three (3) distinct types of Machine Learning algorithms, namely the Decision Tree, Random Forest, and Support Vector Machine. The Auto Model highlights that the Decision Tree outperformed Random Forest and Support Vector Machine for better prediction. The results of statistical analysis using Auto Model suggest that among the factors that influence office building rental, amenities, and in-house services show significant roles in the model.
Keywords: Office Rent, Machine Learning, Prediction
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI:
Improving Age-Friendly Environment through Pragmatic Language
Authors: Kamarudin Nur Asyikeen , Hamzah Fazlinda , Ismail Shafinar , Talaue Franklin G.
Published: April 2022

Declining vocabulary and poor comprehension of complex sentences are some depleting language skills faced by the elderly. As such, this study explored the cues that construct young people's understanding of effective communication within the older and young adult dyad. Qualitative data retrieved from open-ended questions were thematically analysed, and specific facets that contribute to understanding age-related differences were developed. The results catalysed the development of the Integrative Language-based Communication Diagram that could reduce the prevalence of communication breakdown. This environmental approach can also help elders adapt communication to be a necessary tool for living safely and independently.
Efficacy of a Plant-based Diet (Semi-lacto-ovo-vegetarian Diet) for Treating Constipation
Authors:   Division of Gastroenterology, Nakadori General Hospital, 3-15 Misono-cho, Minami-Dori, Akita City 010-8577, Japan, Chiba Mitsuro , Tsuda Satoko ,   Current Affiliation: Division of Gastroenterology, Akita City Hospital, 4-30 Matsuoka-machi, Kawamoto, Akita City 010-0933, Japan, Tozawa Haruhiko ,   Division of Gastroenterology, Nakadori General Hospital, 3-15 Misono-cho, Minami-Dori, Akita City 010-8577, Japan
Published: April 2022

A modern lifestyle, including dietary westernization, has increased the prevalence of constipation. The authors developed a plant-based diet for inflammatory bowel disease. This study investigated whether a diet containing a high amount of dietary fiber is also effective for constipation. Consecutive patients with constipation were recruited in this study from April 2003 to March 2004. Their constipation was unresponsive to a conventional laxative. The patients were provided a plant-based diet during hospitalization for around two weeks. The plant-based diet was a semi-lacto-ovo-vegetarian diet: unrefined whole brown rice, fish once a week, and meat once every two weeks. The diet contained 29.9±1.9 g of dietary fiber/1,700 kcal. The plant-based diet score, where a higher score indicates greater adherence to the plant-based diet, was 35. A diet of 30 kcal/kg of standard body weight was provided. Defecation within two days with the diet alone or in combination with laxatives was regarded as highly effective and effective, respectively. Eleven patients (three men and eight women, 16 to 92 years old; median age: 70 years) were included; seven patients had no complications of constipation, but the remaining four patients had complications that included fecal impaction, megabowel, colonic pseudo-obstruction, and abdominal distention. Among the seven patients with uncomplicated constipation, the diet was highly effective in six patients and ineffective in one patient. It was effective in all four patients with complicated constipation. There were no adverse effects of the diet. The mean plant-based diet score before hospitalization in nine cases was 18.0. A clinical path of 13 days of hospitalization for the management of uncomplicated constipation was designed. The plant-based diet was safe and highly effective for uncomplicated constipation and effective for complicated constipation. A plant-based diet can be introduced as a special meal in a hospital setting for patients suffering from serious constipation.
Application of different control algorithms on a ‘home-made’ temperature control lab kit
Authors: Nguyen Nhu Tuong An , Do Vinh Quang , Pham The Thinh , Tran Nguyen Tuan
Published: April 2022

Providing enough facilities for students to do laboratory activities is important. An existing useful kit was proposed for students learning a variety of control engineering topics. A temperature control lab kit is made from scratch using common electronics components as a replacement for the original TCLab introduced by Hedengren (Hedengren et al., 2019). Mathematical models of the system derived from theoretical and experimental methods are simulated in Matlab/Simulink to verify their accuracy to the physical kit. Different control algorithms such as: On/Off, PID, Fuzzy are then applied on the Kit as well as its mathematical models to illustrate their control feasibility. Human machine interface (HMI) is also designed using Matlab GUI allowing an operator to select a control algorithm, tune control parameters and monitor parameters of the process. Experimental results show that the derived models can reflect quite well dynamics of the physical kit with temperature deviation among them in the range of ±3°C.  This confirms that the kit is well-suited for teaching different control topics such as system modelling, system identification, classical control and advanced control algorithms.
Defense Mechanism of the Immune System Against Hepatitis C Infection
Authors: Alovisi Caroline de Souza , Vieira Gislaine dos Santos Rodrigues , de Melo Lucas Souza , Fernandes Maria Clara Oliveira , Leite Cleber Queiroz , Fernando Susanna Cristina de Carvalho , Lúcio Marcela Fernandes , Freitas Iasmin Kelly Echer Vieira , da Silva Poliana Alves , Peres Julia Garcia , Santos Brian França dos , Borges Stefany Ohana Oliveira Costa , Santos Mariana Bezerra dos
Published: April 2022

Hepatitis C is an inflammatory process caused by a virus of the genus Hepacivirus. It can be triggered acutely or chronically, the latter being predominant. Chronic hepatitis C (CHC) has a worldwide prevalence in about 1% of the population. Hepatitis C virus infection (HCV) has a diverse genetic variety, which makes its elimination difficult.The present work emerges as a need to understand the mechanisms of defense action against HCV in the human body. The study was based on a literature review, based on research in articles from the SciELO and PubMed platforms, using the descriptors hepatitis C, genetics and immune system associated through the Boolean operators OR and AND. In the end, 15 articles were selected that guided the research of the work. In research, it was found that the virus infection can present in the acute phase or in the chronic phase, in which most cases tend to progress from an acute infection barely detectable by the immune system to a persistent chronic infection. In addition, it was observed that T cells during the chronic phase have their ability to resolve reduced, because, in the acute phase, because of the virus, a large variability does not allow T cells to create neutralizing antibodies or memory cells, therefore, when they present the chronic stage, it causes these defense cells to collapse. Much progress has been made in understanding the immune mechanisms that HCV stimulates, however there are still many gaps that need to be closed.
Effect of Credit Information Bureau and Appraisal Methods on performance of Commercial Banks in Mwanza Region
Authors: Pauline Emmanuel , N Dr Viswa Nadham
Published: April 2022

This study intended to identify the effect of credit information bureau and appraisal methods on performance of commercial banks in Mwanza Region. Specifically, the study intended to assess the effect of Credit Reference Bureaus’ information sharing on the credit performance of commercial banks, to assess the effect of the credit scoring appraisal method employed on the performance of commercial banks and to assess the effect of non-performing loans on the performances of Commercial Banks in the Mwanza Region. The study was guided by three theories; the theory of asymmetric information, moral hazard theory and multiple - bank lending model. The study adopted a descriptive research design, sampling 105 respondents randomly and purposefully and collected data through questionnaires. The aim is to establish the effect of credit information bureau and appraisal credit scoring methods on the performance of commercial banks in the Mwanza Region. Results revealed that credit information bureau had a positive, strong effect on the credit performance of commercial banks, and this effect is significant in Mwanza region. Non-performing loans had a positive, weak effect on the credit performance of commercial bank and it was not significant. Finally the credit scoring appraisal approach has a negative, weak effect on commercial bank credit performance. The study concluded that credit information bureau has a significant influence on credit performance of commercial banks and therefore should be used to reduce non-performing loans. The study recommended that banks should continue to use the credit reference bureau’s information-sharing services as it enhances their profitability through the reduction of non-performing loans.
Perceived benefits of E-Banking and its Relationship on Banking Performance in Tanzania
Authors: Switbert Steven , Baleche Dr. Asha
Published: April 2022

Not so long ago, numerous banks in Tanzania have commenced using of digital technologies to influence business transactions; however, there is little understanding on the perceived benefits of these products on the performance of the banks. The study scrutinized the perceived benefits from using E-Banking and its relationship on banking performance in Tanzania taking CRDB and NMB banks as the case study. The specific objectives of the research were three and they include;(i) look on benefits of internet banking and its effect on banking performance, (ii) to assess the perceived benefits of mobile banking and how it impacts the banking performance and (iii) to determine the perceived benefits of ATM services and how it impacts on banking performance. The study adopted a quantitative research design whereby a questionnaire was distributed to 352 banks customers in Mwanza region in an attempt to arrive to a larger sample of respondents. A simple random sampling technique was used in this study so as to allow an equal chance of participants to fill up in the questionnaire and to reduce the elements of bias. The regression results on the overall model showed that the model accounted for adjusted R2 value of 51.3% of the variance explained by the indicator; and the F-statistic of 124.391 which was significant as p = .000. With respect to individual variables, the results of the study brought out forward that the benefits of internet banking were positively related to banks performance although the effect was moderate. Similarly, ATM teller machines and mobile banking had positive and significant effects on the banking performance. In the end it was recommended for commercial banks to improve awareness to customers on some of the e-banking product like internet banking, in addition the commercial banks are supposed to maximize the number of e-banking product so as to minimize congestion on banking premises, and to place banking facilities to various locations to ease access by customers.
Effect of Advertising Media on Sales Performance of Cable TV Network Firms in Mwanza City, Tanzania
Authors: Ritagrace Rogars , Batonda Gerry
Published: April 2022

The study aimed to investigate the impacts of advertising media on sales performance of firms in Cable TV network sector in Mwanza city, Tanzania. Specifically, this study concentrated in determining how digital marketing affects sales performance, determining effect of TV/Radio on sales performance of firms, assessing effect of outdoor (out of home) on sales performance.. This study employed quantitative methodology. The targeted population of the study was about 414 network managers from the six Cable TV network service providers and A sample of 83 network managers, selected from a population of 414 Cable TV network firms and were selected using simple random sampling technique. Questionnaire and documentary review are used to collect data. The study employed descriptive statistics and inferential statistics. The results revealed that all the advertising media namelydigital marketing, TV/Radio and outdoor had a significantly positive effect on sales performance of Cable Network firms. The study further found that mobile marketing had the highest effect of firms’ ales performance followed by outdoor adverting, then social media marketing and lastly TV/Radio. The study lastly recommends that management should create readiness of the company in terms of ensuring products and organization area, and establish a great team. The study also recommended that Cable TV firms should use more of modern advertising especially mobile marketing and social media marketing as they can be accessed by customer 24/7/365 and will reach more people. The marketing/Advertising department should develop marketing plan for advertising to assist measuring effectiveness of each advertising media and hence this can help in developing effective marketing activities.
Desarrollo y validación del Instrumento FF para evaluar el funcionamiento familiar
Authors: Barreras Miranda Mary I. , Muñoz Cortés Gerardo , Pérez Flores Laura M. , Gómez Alonso Carlos , Fulgencio Juárez Mónica , Estrada Andrade María E.
Published: April 2022

Objetivo: desarrollar y validar un instrumento de evaluación del funcionamiento familiar. Métodos: estudio de validación, realizado en la Unidad de Medicina Familiar No. 80 del Instituto Mexicano del Seguro Social en Morelia, Michoacán, México; de marzo 2018 a agosto 2019. Fase 1. Redacción de reactivos mediante modelo McMaster; fase 2. Adecuación de la prueba mediante análisis cualitativo de reactivos: presentación del instrumento, claridad en la redacción, pertinencia de las variables con los indicadores, relevancia del contenido y factibilidad de la aplicación, aplicación de pruebas estadísticas; reducción de reactivos, pertinencia, rotación varimax y varianza; fase 3. Fiabilidad y validez de convergencia contra ff-sil. Resultados: fase 1. Construcción de un instrumento inicial de 107 reactivos con seis dominios. Fase 2. Tras prueba piloto en cien sujetos se eligieron 79 reactivos con pertinencia >90 y tras un análisis factorial con factor de reducción por diez jueces se creó un instrumento final de 35 reactivos con redistribución de los mismos por el método de rotación de varimax, se asignaron seis dominios: resolución de problemas (7 reactivos), comunicación (10 reactivos), roles (5 reactivos), involucramiento afectivo (2 reactivos), respuestas afectivas (8 reactivos) y control de conductas (3 reactivos); con una varianza total de 74.1. Fase 3. Instrumento final de 35 reactivos que categoriza las familias en: funcional (141-175 puntos), disfuncional leve (106-140 puntos), disfuncional moderada (71-105 puntos) y disfuncional severa (35-70 puntos). Instrumento final con alfa de Cronbach de 0.962 vs 0.905 del ff-sil. Conclusión: se construyó un instrumento de 35 reactivos confiable que mide el funcionamiento familiar.
Gesture-Controlled User Interfaces, What Have We Done and Whats Next?
Authors: Chandra Vishakha , Katiyar Dr. Devesh , Goel Gaurav
Published: April 2022

Abstract: To meet the challenges of present computing, researchers working towards break away from traditional types of interaction. This paper identifies new trends in technology, it’s uses and advantage. We concluded that Gesture controlled user interface gives realistic opportunities especially for those users who are uncomfortable with commonly used devices. It’s appropriate for older and disabled people. Gesture controlled user interface has some potential to improve quality of life especially for older and disabled people along with general users. Keyword: Gesture control, user interfaces, elderly, appearing and ambient devices
An Approach to Biosensors Principle and its Applications
Authors: Sharma Dr. Subhash Kumar , Srivastava Dr. Shailendra Kumar
Published: April 2022

Abstract: Biosensors are the device in which there is a coupling of biological sensing element with a detector system using a transducer. In comparison with any other currently available diagnostic device, biosensors are much higher in performance in terms of sensitivity and selectivity both. Biosensors have found potential applications in the industrial processing and monitoring, environmental pollution control, also in agricultural and food industries. Important features for commercialization of the biosensors are selectivity, sensitivity, stability, reproducibility and low cost. This article reviews the brief history, basic principles, and the various types’ of biosensors available. Keyword: Biosensors, Principle, Types and Application
OCR Studymate
Authors: Pathak Kavita , Saraf Shreya , Wagh Sayali , Vishwanath Dr. Saroja
Published: April 2022

Abstract: As we are familiar that there are many languages around the world, which many of us might even not be aware of but due to globalization and digitalization we have got to see and learn many languages. During those days of colonization, English became an integral part of many people’s language and still continues to be in dominance. Hence, inarguably English is one of the prominent languages that is spoken worldwide. But we also cannot deny the fact that there are still many people across the world who aren’t familiar with this language and face difficulties when most of the texts are written in this particular language. For instance, Indian being one of the countries where there are more than 121 languages and every state has its own dialects. So, it becomes difficult for the people who are less familiar with English or any other language that they aren’t familiar with. To overcome these issues and help people who are from vernacular medium or whose native language is other than English, there are already many applications and systems around the world which is appreciable. Most of the existing systems that are present currently have built separate application for each and every step which could be little overwhelming for someone who is not very mobile friendly specifically people with age group above 60. So, the applications are divided according to the steps like capturing text image through camera, then another application for translation which could be done through any translation API and lastly for scanning we have Optical Character Recognition (OCR) scanner for text. But problem is that people expect that the application that they are using should be easy to use, simple to reach and does everything in one go. So, the application that we have proposed makes it easy for people and provides them with a new idea to translate the unfamiliar language (specifically English) into their native language or the languages that are known to them. So, this mobile application captures images which are text based and has important messages or any documents from real world that is important to be translated, and once capturing of image is done then the text is extracted and at the same time identification of language is done of extracted text, and then using Google translation (we have used this translation api) language is translated into their chosen language( we have more than 50 languages to choose) and then the result is displayed on the screen. Keywords: Text recognition, Text Translation, Language Identification, Natural Language Processing, Android, ML kit
Directional Search Algorithm Analysis
Authors: Sharma Keshav , Shetty Pradyum , Shetty Rajith , Lade Prof. Savita
Published: April 2022

Abstract: Apps such as Google maps have inevitably become the go-to app for travelling & we are all heavily reliant on them. But as developers can the ones starting in this field grasp the concept of these algorithms easily? Being able to use such navigational tools outdoors has been very helpful but the same cannot be applied indoors. everywhere. But understanding the core concepts & which algorithm will perform how in different situations can bring about a big change. In this project we plan to help the end-user ( developers, students ) visually study the search algorithms for the shortest distance between two points and how it is calculated by the various algorithms, thus being able to pick the best one possible. One of the main reasons to add visualizations is that we, humans, are better visual learners. Keywords: Navigation, Directional Algorithms, GUI, Shortest distance,
diri untuk meningkatkan motivasi belajar pada remaja dengan conduct disorder
Authors: Rohman Anita
Published: April 2022

Conduct disorder is a common and  highly destructive psychiatric disorder that  usually  appears in childhood or adolescence and is characterized by severe antisocial  and aggressive behavior.  In this case, the subject  often started physical fights, stole small items without facing a victim, often went out at night even though his parents prohibited him from starting  before  13 years old, often skipped school  starting  before  the age  of 13 years, and behavioral disorders causing significant stress or dysfunction. clinical social aspect. Meanwhile, learning motivation is defined as a process in which goal-directed learning  activities are initiated and maintained. Subjects have  low learning  motivation which is indicated  by the absence of perseverance to do assignments, lack of interest  in learning,  lack of independence to do assignments, lack of appreciation in learning, and  lack of confidence and  pleasure in solving problems in lessons. The  assessment methods used were  interviews, observation, Wechsler Adult Intelligence Scale (WAIS), graphic tests (DAP, BAUM, HTP), Saks Sentence  Completion Test  (SSCT), and  self reports. The intervention used is self management. The result of the intervention is that the subject  has  been  able to improve the behavior  of doing the task from 0 times  to 3 times  in one  week.  Subjects were  also  able  to reduce the intensity  and  duration  of excessive play behavior from 4 times a week with a duration  of more  than 6 hours  per day, to 2 times a week with a duration  of 2-4 hours  per day.
Instagram sebagai Media Pembelajaran Sejarah di Masa Pandemi Covid-19
Authors: Julian Dewantara Billy , Aman Aman
Published: April 2022

The spread of Covid-19 which has been going on for a long time has hit various countries, including Indonesia and even the world. The spread of Covid-19 has had an impact on various sectors, including the education sector. Efforts made by the government in suppressing the spread of the Covid 19 virus are by wearing masks, keeping a distance until the issuance of regulations related to education in Indonesia that enforces the teaching and learning process to be carried out online or learning from home (BDR). This study aims to analyze the use of Instagram in learning history during the covid 19 pandemic. This research was conducted at SMAN 2 Pandeglang using a qualitative method with a case study approach. Data were collected by means of observation and in-depth interviews. The results show that Instagram can be used as a learning medium by utilizing the various features available in it. For example, by using the IG live feature to deliver material directly. In addition, students can also be given the task of making videos about learning materials and uploading them via Instagram.
Peningkatan Hasil Belajar Peserta Didik Pada Pelajaran Sejarah Melalui Model Pembelajaran Student Facilitator and Explaining di Kelas X IPS 3 SMA Negeri 1 Bantan
Authors: Sari Wulan , Ibrahim Bedriati , Asil Asil
Published: April 2022

Rendahnya hasil belajar peserta didik kelas X IPS 3 SMA Negeri 1 Bantan disebabkan karena guru hanya sekedar menyampaikan materi pembelajaran tanpa adanya model pembelajaran yang efektif sehingga siswa kurang aktif saat mengikuti proses pembelajaran dan pada akhirnya mengakibatkan rendahnya pemahaman siswa terhadap materi pembelajaran sejarah. Penelitian ini bertujuan Untuk mengetahui aktivitas guru, aktivitas belajar siswa setelah menggunakan model  pembelajaran Student Facilitator and Explaining terhadap hasil belajar pelajaran sejarah Kelas X IPS 3 SMA Negeri 1 Bantan. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) dengan desain penelitian one group pretest-posttest design. Pengambilan sampling penulis menggunakan sampling jenuh, kelas unit yang dipilih kelas X IPS 3 SMA Negeri 1 Bantan. Hasil penelitian ini menyimpulkan bahwa pada observasi siklus I nilai aktivitas siswa adalah 76 dan mengalami peningkatan pada siklus II yaitu 84,6. Dalam hal ini dapat dibuktikan bahwa adanya peningkatan nilai aktivitas belajar siswa dari siklus I dan siklus II yaitu 8,6. Aktivitas guru pada siklus I memperoleh nilai sebesar 62,5% (cukup) dan meningkat pada siklus II menjadi 85,4 % dengan kiteria baik. Sedangkan untuk hasil belajar pada post test siklus I rata-rata ketuntasan diperoleh yaitu 30% sebanyak 9 siswa yang melebihi KKM yang telah ditentukan, pada sisklus II rata-rata ketuntasan post test adalah 86,7% sebanyak 24 siswa nilai nya yang melebihi KKM.

Kata Kunci:

Model Pembelajaran Student Facilitator and Explaining, Pelajaran Sejarah, Hasil Belajar.
Ayurveda Interpretation of Kalpana: A Classical Review
Authors: Ashok Jolhe Mrunal , Prashant Kale Anupama , Matkar Prajakta Devidas
Published: April 2022

Kalpana (formulations) is a method or process of drug preparation and these specific formulations meant for particular purposes. The knowledge of drug preparation or Kalpana helps to enhancing potency and palatability of drug. The particular dosage forms and processing techniques employed for definite purposes. Charaka Samhita mentioned concept of Samskaras (fortifications) that helps to increase potency and qualities of drugs. Acharya Harita described different types of Kashaya (Saptavidha Kashaya); similarly other ayurveda texts also mentioned various types of classical Ayurveda formulations. Present article explored Ayurvedic interpretation of Kalpana and utility of this concept.
Role of Viruddha Ahara towards Skin and Allergic Disorders; an Ayurveda Review
Authors: Pillewan M. B. , Verma Anand Prakash , Naharia Ranjita
Published: April 2022

Viruddha Ahara is Ayurveda view of food incompatibility; Viruddha Ahara referred several types of food incompatibility including food–food interactions and food processing interactions, etc. Diet and its combinations that affects metabolism of tissue, inhibits process of tissue formation, alter physiological process of body and having opposite property, etc. are termed as Viruddha Ahara or incompatible food. The inappropriate quantity and quality of food and improper timing of meal, etc. also comes under the heading of Viruddha Ahara. With respect to concept of Viruddha Ahara Ayurveda has described different food incompatibilities i.e.; Samskar Viruddha, Samyoga Viruddha and Veerya Viruddha, etc. Viruddha ahara can triggers pathogenesis of several diseases including Visarpa, intoxication, Shukra Dhatu Dushti, rhinitis, infertility, Kustha roga and allergic disorders, etc. Present article explored role of Viruddha ahara in skin and allergic disorders.
Ayurveda Concept of Dravyaguna w.s.r. to Significance of Guna and Rasa: A Review
Authors: Jadhav Atul , Babar Tejaswini
Published: April 2022

The Ayurveda philosophy of Dravyaguna Vigyan mainly talks about properties of substances which are responsible for specific pharmacological and biological responses. This science deals around Namajnana, Gunajnana, Yuktijnana and Rupajnana, etc. The Dravyaguna means properties materials which includes drugs as well as dietary substances. As per Ayurveda Rasa, Guna, Virya, Vipak and Prabhav are inherent characters of substances that contributed towards some biological and therapeutic responses. In this regards different types of Guna (quality) and Rasa (taste) play major role for the specific action of substances. Considering this aspect present article summarizes Ayurveda concept of Dravyaguna W.S.R. to clinical significance of Guna and Rasa.
Regulatory aspects on repurposing of drugs in the management of COVID-19
Authors: Bhatia Priyansha , Chauhan Akash , Porwal Gagan , Shukla Vikesh
Published: April 2022

Drug repurposing involves the disquisition of using medicines for new remedial purposes. With the increasing waste production, given the costs and tiresome pace of new medicine search, repurposing of medicines already in the market to treat all kinds of conditions is decreasingly getting a selective approval because uses the composites that have been de-risked, with lesser development costs and shorter timelines of developing the drug. Colourful and experimental data approaches have been used for the identification of the medicines to be repurposed. There are also major technical and non-supervisory challenges that need to be addressed. In this review, we present the different kinds of approaches used for medicine repurposing, study the challenges faced by the scientists during repurposing as well as recommend ways by which these challenges could be overcome to help realize the full potential of medicine repurposing. Drug displacing is the repurposing of an already existing medicine for the treatment of a different complaint or medical condition than that for which it was firstly developed. This is one line of scientific exploration which is being pursued to develop safe and effective COVID-19 treatments. Other exploration directions include the discovery of a COVID-19 vaccine and convalescent tube transfusion. Several being antiviral specifics, preliminarily developed or used as treatments for SARS, MERS, HIV/ AIDS, and malaria, have been delved as implicit COVID‐19 treatments, with some moving into clinical trials. Monoclonal antibodies under disquisition for repurposing include anti-IL-6 agents (tocilizumab) and anti-IL-8 (BMS-986253). This is in resemblance to new monoclonal antibody medicines developed specifically for COVID-19.
Audit requirements and expectations, The good and better about MDSAP Regulations
Authors: Sagar Vidya , Patel Deepak , Patel Piyush , Kumar Anil , Rana Avni , Trivedi Bhavin , Bavisa Vipul
Published: April 2022

The most sure-fire way to pass MDSAP audit with flying colours is to have an effective Quality Management System (QMS). Having a good QMS will make sure work is correctly documented, kept up to date, and easy to present to an auditor. For regulators too, it means a reduced burden. There is pooling of regulatory resources. The audits are conducted by Auditing Organizations designated by the regulatory bodies. The MDSAP program is expected to improve audit predictability because a standardized audit model has been introduced. Every audit follows the same set of steps. For the first time, a grading system is introduced for noncompliance. This approach helps reduce subjectivity. MDSAP has a very rigid auditing process to ensure the proper market authorizations have been obtained and facility registrations have occurred but not represent Marketing Authorization. Recently proposed greater alignment of FDA Quality System Regulation (QSR) with ISO 13485, would bring US QMS requirements for medical device manufacturers closer in line with quality system requirements in markets such as the European Union, Japan and Australia, potentially streamlining medical device registration and compliance processes across the US and other markets.
Comparative overview of enhancing Drug pricing transparency in India and USA
Authors: A. Shah Radhika , Patel Kalpana G. , Shah Purvi
Published: April 2022

The United States and other different countries, drug prices are out of control. In that the prescription drug prices increasingly the medical costs and other different healthcare costs. The branded drugs are launched with high prices that increase by double percentage over year. So, many states and countries are focusing on new ways or new approaches to drug pricing problems using different ways and  clarity about drug price transparency are mainly that the study about drug transparency and identify the cost key drivers. India is one of the world's developing countries. The ability to obtain health-related services at a reasonable cost is a major worry for them. As a result, medical costs are a determining element for health-care facilities, particularly when it comes to price management of health-care institutions with a greater budget. NPPA (National Pharmaceutical Pricing Authority) and DPCO (Department of Pharmaceutical Pricing and Control) are two Indian regulatory bodies that oversee pharmaceutical pricing (Drug Pricing control order). Despite the establishment of the DPCO, significant price fluctuation is observed between goods containing the same API (Active Pharmaceutical Ingredient), and various reasons are responsible for this. TRIPS (Trade Related Intellectual Property Rights) offers Compulsory Licenses for which drugs have a distinctive function to play in the affordability of medicines to minimize the stated problem and govern the trade practice by patent holder/brand maker. Essential medicine is a basic requirement of the health-care system in order to serve its consumers, and as a result, an effective and overt price restriction on drugs is currently required.