bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on the Influence Mechanisms of Neighborhood Vitality and the Characteristics of Spatial and Temporal Differentiation in the Urban Fringe Areas of Wuhan City
Authors: Long Yan , Hu Siyu , Lu Zhengyuan , Cheng Lianghao , Zhen Cairui , Shao Jingmei , Zheng Yuqiao , Zhou Xuehui , Li Jin , Lin Yudi , Zhang Shu , Wang Yue , Luo Tianyue , Zhao Haijuan , Liu Xuejun
Published: October 2024

Achieving effective integration of urban–rural relationships and promoting the flow of resources between urban and rural areas in megacities are a key priority in the development of China’s new urbanization efforts. As a transitional zone between urban and rural areas, the urban fringe is the frontier of urban–rural integration. The specific research object of this paper is the urban fringe areas of Wuhan City. This paper quantifies the neighborhood vitality of the fringe areas by the short-stay visitors in the fringe areas and selects the 5D elements of the built environment and social media data from multiple sources to construct the indicator system assessing the neighborhood vitality of the urban fringe areas. This paper analyzes the spatial distribution characteristics of neighborhood vitality and its influencing factors in urban fringe areas and investigates the connection between neighborhood vitality and its influencing factors through the application of the multi-scale geographically weighted regression (MGWR) model. Based on the regression results, relevant planning recommendations are made on how to enhance the vitality of neighborhoods in urban fringe areas. The results show that the index system constructed by “5D” elements of built environment and social media data can well explain the spatial distribution of neighborhood vitality in urban fringe areas. Among the influencing factors, the absolute value of the correlation coefficient of network exposure is the largest, followed by road density and functional density. Thanks to the different bandwidths given by MGWR to the influencing factors, the global influencing factors are only two indicators—development intensity and functional mixing degree—while the other influencing factors are all local, and the influence degree of different regions is different, so it is necessary to analyze and put forward different planning suggestions accordingly.
Operational Performance Evaluation Model for Food Processing Machinery Industry Chain
Authors: Zhang Huiqi , Chen Kuen-Suan , Yu Chun-Min , Zhang Qiansha , Lo Wei
Published: October 2024

This study aims to create a performance evaluation model for the food processing machinery industry. The goal is to help food processing plants improve both process quality and competitiveness. Additionally, component failures may disrupt the continuous operation of the food processing machine, potentially resulting in insufficient production and delays in delivery, which in turn leads to cost losses. For the sold food processing machinery, decreases in the average number of failures within a unit of time, the average repair response time when a failure occurs, and the average repair duration are three crucial factors in minimizing the total expected loss due to machine failures. Based on these three important factors, this study established the following evaluation indices: (1) the processing performance index, (2) the repair reporting performance index, and (3) the maintenance performance index. These indices serve as tools for assessing the performance of the three key operational aspects. This study employed a radar chart to construct the evaluation model, which can directly compare the critical values with the point estimates of three indices. Consequently, this approach can judge whether the operational performance has achieved the required level. This can maintain the simplicity and usability of point estimates while reducing the risk of misjudgment due to sampling errors.
Joint Optimization-Based Texture and Geometry Enhancement Method for Single-Image-Based 3D Content Creation
Authors: Park Jisun , Kim Moonhyeon , Kim Jaesung , Kim Wongyeom , Cho Kyungeun
Published: October 2024

Recent studies have explored the generation of three-dimensional (3D) meshes from single images. A key challenge in this area is the difficulty of improving both the generalization and detail simultaneously in 3D mesh generation. To address this issue, existing methods utilize fixed-resolution mesh features to train networks for generalization. This approach is capable of generating the overall 3D shape without limitations on object categories. However, the generated shape often exhibits a blurred surface and suffers from suboptimal texture resolution due to the fixed-resolution mesh features. In this study, we propose a joint optimization method that enhances geometry and texture by integrating generalized 3D mesh generation with adjustable mesh resolution. Specifically, we apply an inverse-rendering-based remeshing technique that enables the estimation of complex-shaped mesh estimations without relying on fixed-resolution structures. After remeshing, we enhance the texture to improve the detailed quality of the remeshed mesh via a texture enhancement diffusion model. By separating the tasks of generalization, detailed geometry estimation, and texture enhancement and adapting different target features for each specific network, the proposed joint optimization method effectively addresses the characteristics of individual objects, resulting in increased surface detail and the generation of high-quality textures. Experimental results on the Google Scanned Objects and ShapeNet datasets demonstrate that the proposed method significantly improves the accuracy of 3D geometry and texture estimation, as evaluated by the PSNR, SSIM, LPIPS, and CD metrics.
A Probabilistic Approach for Threshold Reliability Structures with Three Different Types of Components
Authors: Triantafyllou Ioannis S.
Published: October 2024

In the present work, we study threshold reliability systems consisting of three different kinds of independent components. Within these structures, the components belonging to the same type, share a common reliability and the same weight. The reliability attributes of the aforementioned systems are investigated in some detail. Explicit expressions for calculating their reliability function, the mean time to failure and the corresponding Birnbaum’s importance measures are established. For illustration purposes, several numerical results are presented, while some concluding remarks about the impact of the design parameters of the underlying structures are delivered. A short discussion for potential future work is also developed.
Mimicking Urinary Tract Infections Caused by Uropathogenic Escherichia coli Using a Human Three-Dimensional Tissue Engineering Model
Authors: Pellerin Félix-Antoine , Dufresne Élodie , Chabaud Stéphane , Orabi Hazem , Bolduc Stéphane
Published: October 2024

Uropathogenic Escherichia coli are the main causal agent of urinary tract infections. These diseases can affect more than half of women during their lifetime. Moreover, recurrent urinary tract infections can affect up to 30% of patients, leading to higher social and economic costs for the community. No efficient treatment against the recurrent form of the disease has been discovered. Due to the low average rate of successful translation from 2D cell culture and in vivo animal models into clinical trials, new models that mimic pathologies, such as those produced by tissue engineering, are needed. A model of human-derived 3D bladder mucosa was produced by tissue engineering techniques using collagen gels and organ-specific primary human stromal and epithelial cell populations. This model was used to mimic the different steps of a urinary tract infection: adhesion, invasion, intracellular bacterial community and quiescent intracellular reservoir formation and, finally, bacteria resurgence after umbrella cell exfoliation through chitosan exposure to mimic the recurrent infection. The uropathogenic strain UTI-89-GFP was used as infectious bacteria and BL-21-GFP strain as a control. Our model is unique and is the first step toward mimicking the different phases of a UTI in a human context.
Probiotic Characteristics and the Anti-Inflammatory Effects of Lactiplantibacillus plantarum Z22 Isolated from Naturally Fermented Vegetables
Authors: Wang Shiyu , Nie Ziyu , Zhu Li , Wu Yanyang , Wen Yashi , Deng Fangming , Zhao Lingyan
Published: October 2024

Currently, there is increasing interest in the commercial utilization of probiotics isolated from traditional fermented food products. Therefore, this study aimed to investigate the probiotic potential of Lactiplantibacillus plantarum (L. plantarum) Z22 isolated from naturally fermented mustard. The results suggest that L. plantarum Z22 exhibits good adhesion ability, antibacterial activity, safety, and tolerance to acidic conditions and bile salts. We further determined the anti-inflammatory mechanism and properties of L. plantarum Z22 and found that L. plantarum Z22 could significantly reduce the secretion of pro-inflammatory cytokines, including interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and the expression of the pro-inflammatory mediator cyclooxygenase-2 (COX-2) protein in LPS-induced RAW 264.7 cells. In addition, L. plantarum Z22 also effectively inhibited the signaling pathways of nuclear factor κB (NF-κB) and mitogen-activated protein kinases (MAPKs). This effect can be attributed to a decrease in the levels of reactive oxygen species (ROS) and increased heme oxygenase-1 (HO-1) expression. Moreover, whole-genome sequencing revealed that L. plantarum Z22 contains gene-encoding proteins with anti-inflammatory functions, such as beta-glucosidase (BGL) and pyruvate kinase (PK), as well as antioxidant functions, including thioredoxin reductase (TrxR), tyrosine-protein phosphatase, and ATP-dependent intracellular proteases ClpP. In summary, these results indicated that L. plantarum Z22 can serve as a potential candidate probiotic for use in fermented foods such as yogurt (starter cultures), providing a promising strategy for the development of functional foods to prevent chronic diseases.
Brevundimonas aurifodinae, sp. nov., an Aerobic Anoxygenic Phototroph Resistant to Metalloid Oxyanions Isolated from Gold Mine Tailings
Authors: Maltman Chris , Messner Katia , Kyndt John A. , Yurkov Vladimir
Published: October 2024

A polyphasic taxonomic study was carried out on the rod-shaped, orange-pigmented strain C11T, isolated from gold mine tailings. Sequencing of the 16S rRNA gene showed a relatedness to Brevundimonas, with a 98.4% and 98.2% similarity to Brevundimonas bacteroides and Brevundimonas variabilis, respectively. The average nucleotide identity and a digital DNA–DNA hybridization with the closest phylogenetic neighbor of strain C11T indicate distinction at the species level, further confirmed by the differences in physiology. C18:1 ω7c is the dominant cellular fatty acid. Its DNA G + C content is 68.3 mol %. Its predominant ubiquinone is Q-10; 1,2-Di-O-acyl-3-O-α-D-glucopyranuronosyl glycerol, phosphatidylglycerol, 1,2-di-O-acyl-3-O-α-D-glucopyranosyl glycerol, and 1,2-di-O-acyl-3-O-[D-glucopyranosyl-(1→4)-α-D-glucopyranuronosyl] glycerol are its major polar lipid constituents. This bacterium produces bacteriochlorophyll a and tolerates high concentrations of (μg/mL) the following: tellurium (>1500), selenium (1000 to >5000), and vanadium (>5000) oxyanions. The data support the inclusion of the strain C11T into the genus Brevundimonas as a new species with the proposed name Brevundimonas aurifodinae sp. nov. (C11T = NRRL B-61758T; =DSM 118059T).
In Vitro Assessment of Penicillium expansum Sensitivity to Difenoconazole
Authors: Khadiri Mohammed , Boubaker Hassan , Farhaoui Abdelaaziz , Ezrari Said , Radi Mohammed , Ezzouggari Rachid , Mokrini Fouad , Barka Essaid Ait , Lahlali Rachid
Published: October 2024

Penicillium expansum causes blue mold, a major post-harvest disease affecting apples. This disease is commonly managed using fungicides, including Difenoconazole (Dif), a demethylation inhibitor (DMI) approved for its control. This investigation aims to evaluate the baseline sensitivity of 100 P. expansum isolates to Difenoconazole. The isolates were collected from symptomatic apples in 34 storage warehouses across the Fes-Meknes and Draa-Tafilalet regions over three years (2020, 2021, and 2022). The study revealed an increase in the percentage of inhibition of mycelial growth and spore germination of P. expansum proportional to the increasing concentration of the fungicide. Moreover, the results indicate that 46 isolates were able to develop even at a concentration of 5 µg/mL of Dif (the suggested discriminatory dose), indicating reduced sensitivity to this fungicide. The analysis of the values of the effective concentration to inhibit 50% (EC50) of mycelial growth of P. expansum ranging from 0.027 to 1.673 µg/mL (mean: 0.263 µg/mL, variation factor: 62.507) and for spore germination from 0.0002 to 0.787 µg/mL (mean: 0.048 µg/mL, variation factor: 4113.835). The wide variation in EC50 values indicates significant variability in the isolates’ responses to Dif, likely due to diverse sampling in space and time. Our results showed that some P. expansum isolates could grow even at high concentrations of Dif, indicating limited efficacy of this treatment. The EC50 of five isolates exceeded 0.92 µg/mL, suggesting potential resistance. This study indicates reduced sensitivity and possible emergence of resistant strains. Notably, it is the first evaluation of P. expansum sensitivity to Dif in Morocco.
Synthesis and Characterization of Self-Dispersion Monodisperse Silica-Based Functional Nanoparticles for Enhanced Oil Recovery (EOR) in Low-Permeability Reservoirs
Authors: Ding Jun , Cheng Tingting , Fu Cheng , Huang Bin , Yang Erlong , Qu Ming , Liu Shuyu , Wu Jingchun
Published: October 2024

A controllable particle size mono-dispersing nanofluid system has been developed to address the challenges of low porosity and low-permeability in low to ultra-low-permeability reservoirs. This system combines high dispersion stability with enhanced oil recovery performance, and its effectiveness in improving recovery rates in low-permeability reservoirs, where conventional chemical flooding is ineffective, has been well demonstrated. Using the in situ method to prepare monodispersed nano-silica particles, the effects of the water concentration, ammonia concentration, and silica precursor concentration on the morphology, particle size, and formation time of the silica spherical particles were analyzed. Building on this foundation, a partially hydrophobic modified nano-silica oil displacement fluid was synthesized in situ. The system’s dispersion stability, ability to reduce oil-water interfacial tension, and capacity to alter rock wettability were evaluated. Core physical models were used to evaluate the oil displacement efficiency and the permeability applicability limits of the self-dispersing nano-silica oil displacement system. The experiments confirmed that the particle size distribution of the self-dispersing nano-silica oil displacement system can be controlled within a range of 10 nm to 300 nm. The nanofluids exhibited excellent stability, effectively altering the rock wettability from oil-wet to water-wet and reducing the oil-water interfacial tension to approximately 10−1 mN/m. The nano-displacement system increased the recovery rate of the low permeability reservoirs by more than 17%. The in situ modification method used to prepare these self-dispersing nanoparticles provides valuable insights for synergistic enhancement of recovery when combined with other systems, such as surfactants and CO2. This approach also opens up new possibilities and drives further development in the field of nano-enhanced oil recovery chemistry.
The New Method for Ground Insulation Monitoring of the Secondary Circuit in Substations
Authors: Wen Caiquan , Xiong Xiaofu , Wei Xin , Yan Maohua , Rong Hao , Li Dachuan
Published: October 2024

When two-or-more-point grounding faults occur in the secondary circuit of a substation, they will lead to large data measurement errors in the protection, measurement, and control devices, which can easily cause protection malfunction. At present, there is a lack of an online panoramic monitoring system for the secondary circuits of substations, and it is difficult to accurately identify the faults in these secondary circuits. In order to solve this problem, this paper proposes a cloud–edge collaboration framework for the power Internet of Things (IoT), which can accurately identify faults by monitoring the secondary circuit of power grid substations with panoramic online status, reducing maintenance costs and improving overall operational efficiency. Firstly, the collection requirements of current transformer (CT) and potential transformer (PT) fault characteristics in the secondary circuit of the substation are analyzed. The platform architecture of the secondary loop panoramic monitoring system of the cloud-side cooperative substation is proposed, along with the algorithm and data wireless acquisition scheme of the edge computing, cloud computing, and cloud-side system. Furthermore, the edge computing platform and the current and voltage wireless sensors are developed. The maximum error in the accuracy test of the voltage sensor is 1.9180%, while the maximum error in the accuracy test of the current sensor is 1.3406%.
Linear Programming-Based Sparse Kernel Regression with L1-Norm Minimization for Nonlinear System Modeling
Authors: Liu Xiaoyong , Yan Genglong , Zhang Fabin , Zeng Chengbin , Tian Peng
Published: October 2024

This paper integrates L1-norm structural risk minimization with L1-norm approximation error to develop a new optimization framework for solving the parameters of sparse kernel regression models, addressing the challenges posed by complex model structures, over-fitting, and limited modeling accuracy in traditional nonlinear system modeling. The first L1-norm regulates the complexity of the model structure to maintain its sparsity, while another L1-norm is essential for ensuring modeling accuracy. In the optimization of support vector regression (SVR), the L2-norm structural risk is converted to an L1-norm framework through the condition of non-negative Lagrange multipliers. Furthermore, L1-norm optimization for modeling accuracy is attained by minimizing the maximum approximation error. The integrated L1-norm of structural risk and approximation errors creates a new, simplified optimization problem that is solved using linear programming (LP) instead of the more complex quadratic programming (QP). The proposed sparse kernel regression model has the following notable features: (1) it is solved through relatively simple LP; (2) it effectively balances the trade-off between model complexity and modeling accuracy; and (3) the solution is globally optimal rather than just locally optimal. In our three experiments, the sparsity metrics of SVs% were 2.67%, 1.40%, and 0.8%, with test RMSE values of 0.0667, 0.0701, 0.0614 (sinusoidal signal), and 0.0431 (step signal), respectively. This demonstrates the balance between sparsity and modeling accuracy.
CFD Simulation of Stirling Engines: A Review
Authors: Laín Santiago , Villamil Valentina , Vidal Juan R.
Published: October 2024

Stirling engines (SEs) have long attracted the attention of renewable energy researchers due to their external combustion design and flexibility in operating with various heat sources. The mathematical analysis of these devices is conducted by using a broad range of models ranging from basic zero-order to highly detailed fourth-order models, which are implemented through Computational Fluid Dynamics (CFD) simulations. The unique features of this last approach, combined with the increase in computing power, have promoted the use of CFD as a tool for analyzing SEs in recent years, significantly reducing the costs associated with prototype construction. However, Stirling CFD simulations are sophisticated due to the variety of physical phenomena involved, such as volume change, conjugated heat transfer, turbulent compressible fluid dynamics, and flow through porous media in the regenerator. Furthermore, there is currently no comprehensive review of CFD simulations of SEs in the literature; therefore, this contribution aims to fill that gap. Emphasis has been placed on identifying the type of engine, the physical phenomena modeled, the simplifying assumptions, and specific numerical aspects, such as mesh type, spatial and temporal discretization, and the order of the numerical schemes used. As a result, it has been found that in many cases, CFD numerical reports lack sufficient detail to ensure the reproducibility of the simulations. This work proposes guidelines for reporting CFD studies on Stirling engines to address this issue. Additionally, the need for a sufficiently detailed experimental benchmark database to validate future CFD studies is stressed. Finally, the use of Large Eddy Simulations on coupled key engine components—such as compression and expansion spaces, pistons, displacer, and regenerator—is suggested to provide further insights into the specific flow and heat transfer characteristics in Stirling engines.
Sex Differences Exist in the Relationship Between Vertical Jump Performance Biomechanical Parameters and Hamstring/Quadriceps Ratio in Adolescent U18 Track and Field Athletes
Authors: Panoutsakopoulos Vassilios , Kotzamanidou Mariana C. , Manou Vasiliki
Published: October 2024

Isokinetic metrics are suggested to be related to vertical jump performance, but little is known about the possible sex differences in this relationship in adolescent track and field athletes. The aim of the study was to examine the possible sex differences in the strength of the relationship between the kinetic parameters of the vertical squat jump with arms akimbo, the countermovement jump with arms akimbo, and the countermovement jump with free arm swing with the isokinetic parameters of the knee extensor and flexor muscles (angular velocities: 60°/s and 300°/s). In total, 35 (males: 21, females: 14) U18 track and field athletes were examined. The results revealed that the Men U18 group had higher vertical jump performance, higher values in the kinetic parameters of the vertical jump tests, higher knee extensor torque, and higher knee flexor torque in the non-dominant leg compared to the Women U18 group. Significant (p < 0.05) sex differences were observed in the relationship between the isokinetic parameters and the vertical jump performance metrics, as the Women U18 athletes relied more on the knee flexor torque than Men U18 athletes, and demonstrated a stronger negative relationship between selected isokinetic metrics and the pre-stretch gain in the vertical jump tests. In conclusion, it is recommended that young female track and field athletes minimize interlimb asymmetry and improve the convention ratio in their non-dominant leg to optimize vertical jump performance.
Immune Response Against Influenza in a Cohort of Repeatedly Vaccinated Adults During the 2017/2018 and 2018/2019 Seasons
Authors: Guiomar Raquel , Silva Susana Pereira da , Rodrigues Ana Paula , Costa Inês , Conde Patrícia , Cristóvão Paula , Pechirra Pedro , Estragadinho Paulo , Mansinho Kamal , Hungnes Olav , Graça António Silva , Nunes Baltazar
Published: October 2024

Background/Objectives: The influenza vaccination of healthcare workers (HCWs) is recommended each autumn and winter season by the relevant authorities in EU/EEA countries. The objective of this study was to evaluate the impact of repeated trivalent influenza vaccine (TIV) uptake during the 2017/2018 and 2018/2019 seasons on vaccine-derived immunity against influenza. Methods: A cohort study of HCWs vaccinated with an annual TIV was conducted from October 2017 to June 2019. The protective antibodies against the influenza vaccine strains were assessed at three time points: prior to vaccination and at one and six months following vaccination for each season. Sera were tested by hemagglutination inhibition assay. Participants were grouped according to their history of TIV vaccination over four seasons (since 2015/16), with the groups designated as “frequently vaccinated” (≥3 vaccines) and “occasionally vaccinated” (≤2 vaccines). Seroprevalence, geometric mean titer (GMT) and seroconversion rate were compared between the frequently and occasionally vaccinated groups. Results: A total of 97 healthcare workers (HCWs) were enrolled in the study; 49 HCWs participated in both seasons. Thirty-two (43.2%) and forty-three (59.7%) individuals had ≥3 vaccines since 2015/2016, at recruitment and during the 2017/2018 and 2018/2019 influenza seasons, respectively. One month following vaccination, HCWs who had received occasional vaccinations demonstrated a higher prevalence of protective antibodies and a greater GMT for both influenza A(H1N1)pdm09 and A(H3N2) viruses. For influenza B Victoria, the frequently vaccinated HCWs demonstrated a higher seroprevalence rate, seroconversion, and GMT. Conclusions: Previous vaccination can influence the immune response, although without substantially compromising the immunogenicity of annual influenza vaccination. HCW annual influenza vaccination is required to re-establish and maintain the antibody titers against influenza.
Vaccination Knowledge, Attitudes, Perceptions, and Educational Needs of Pharmacists in Singapore: A Cross-Sectional Study
Authors: Au Ally L. , Chia Deborah M. , Ong Pei-Shi
Published: October 2024

Background: Singapore’s adult vaccination coverage is suboptimal, and this can be attributed to a lack of vaccination recommendations and misconceptions. Studies have explored pharmacists’ vaccination knowledge, attitudes, and practice behaviour overseas but limited information about pharmacists in Singapore is available. This study aims to investigate pharmacists’ vaccination knowledge, attitudes towards providing vaccination services, and their educational needs. Methods: A cross-sectional study was conducted on pharmacists in various practice settings using an anonymous online survey. Results: Pharmacists’ vaccination knowledge (median: 2; IQR: 1–3), confidence in providing vaccination services (median: 6; IQR: 5–8), and frequency of providing vaccination services (median: 2; IQR: 1–3) were only average. However, 74.3% of pharmacists agreed that they play an important role as vaccine advocates. Apparent differences in knowledge level (p = 0.008), confidence level (p = 0.001), attitude (p < 0.001), and the frequency of educating patients (p = 0.001) and recommending vaccinations (p < 0.001) were observed among pharmacists from different practice settings. The main barriers identified were discomfort with giving injections (38.5%) and a lack of skills or knowledge (28.3%) at the point of survey. Conclusions: Pharmacists see the importance of their role as vaccine advocates. However, their vaccination knowledge, confidence in providing vaccination services, and practice behaviours are only average due to inadequate training. Continuous professional education is required to increase pharmacists’ readiness to provide vaccination services.
Combating Emerging Respiratory Viruses: Lessons and Future Antiviral Strategies
Authors: Muthukutty Palaniyandi , MacDonald Jaime , Yoo So Young
Published: October 2024

Emerging viral diseases, including seasonal illnesses and pandemics, pose significant global public health risks. Respiratory viruses, particularly coronaviruses and influenza viruses, are associated with high morbidity and mortality, imposing substantial socioeconomic burdens. This review focuses on the current landscape of respiratory viruses, particularly influenza and SARS-CoV-2, and their antiviral treatments. It also discusses the potential for pandemics and the development of new antiviral vaccines and therapies, drawing lessons from past outbreaks to inform future strategies for managing viral threats.
Estimation of Height at Withers Based on Long Bone Measurements of Living Cats
Authors: Poradowski Dominik , Mutlu Zihni , Altundağ Yusuf , Chrószcz Aleksander , Sarıtaş Özlem , Wolińska Joanna , Onar Vedat
Published: October 2024

In this study, coefficients enabling estimation of shoulder height were obtained by taking morphometric measurements from radiographic images of live cats using the radiogrammetric method. For this purpose, a total of 37 adult cats, including 17 females and 20 males, were involved. While the effect of sexual dimorphism was observed on the morphometric data, the presence of sexual dimorphism was only evident in the coefficients (factors) of the humerus and talus. No significant effect of gender was found on the shoulder height estimation coefficients (factors) for other thoracic and pelvic limb bones. Gender had an impact on the slenderness index in all thoracic limbs, but only on the tibia slenderness index among the pelvic limb bones. Generally, female individuals were found to have more slender limbs. It is believed that the obtained coefficients (factors) and index data will contribute significantly to the prediction of archaeological cat morphology.
The Interface Between Veterinary and Behavioral Management of Chimpanzees (Pan troglodytes) in a United States Sanctuary Demonstrated by Two Clinical Cases
Authors: Jackson Raven , Lewis Rebekah , Fultz Amy
Published: October 2024

Chimp Haven is a private, nonprofit organization that serves as the largest chimpanzee sanctuary in the world. The National Institutes of Health supports the federal sanctuary system, which is operated by Chimp Haven, to provide lifetime care for chimpanzees who have retired from biomedical research. Chimp Haven is home to over 300 chimpanzees, with a wide variety of individual health needs including infectious diseases. The chimpanzees live in large, mixed-sex social groups within corrals, multi-dimensional enclosures, and naturally forested habitats, which presents challenges for monitoring and balancing individual versus group needs. Primate veterinarians and animal behavior directors have an obligation to collaborate for the best possible health and welfare outcomes for the species in their care. This manuscript details how veterinarians and behavioral staff at Chimp Haven interface to enhance clinical management and improve chimpanzee welfare using two clinical cases to illustrate this relationship. This is accomplished through the development of individual care plans that include the utilization of welfare assessment metrics and positive reinforcement training programs collaboratively developed between the veterinarians and behaviorists to facilitate voluntary medical procedures without the need for social isolation. Specifically, welfare metrics such as monitoring chimpanzee wounding levels and severity, as well as targeted assessments, involve the input of both the veterinarians and behaviorists. Positive reinforcement training initiatives such as weight loss, heart health, and wound care also require the interface between the two disciplines. The authors aim to demonstrate that working together provides optimal levels of expert care for both the physical and mental health of the chimpanzees in our care.
Pulmonary Delivery of Anti-microRNA Oligonucleotide and Glycyrrhizic Acid Using Ternary Peptide Micelles for the Treatment of Acute Lung Injury
Authors: Kang Minji , Zhuang Chuanyu , Oh Jihun , Lee Minhyung
Published: October 2024

Acute lung injury (ALI) is a devastating inflammatory disease. In lungs with inflammation, microRNA155 (miR155) induces inflammatory cytokines by inhibiting the expression of suppressor of cytokine signaling-1 (SOCS1). In addition, glycyrrhizic acid (GA) has been suggested as an anti-inflammatory drug for ALI, since it is an efficient inhibitor of nuclear factor-κB. In this study, a combined delivery system of anti-miR155 oligonucleotides (AMO155) and GA was developed with R3V6 for the treatment of ALI. R3V6s formed comicelles with cholesterol-conjugated AMO155 (AMO155c) by charge and hydrophobic interactions. GA, an amphiphilic drug, was integrated to AMO155c-R3V6 micelles, producing AMO155c-R3V6-GA ternary micelles. The size of AMO155c-R3V6-GA was smaller than that of AMO155c-R3V6, suggesting that GA integration reduced the size of the micelles effectively. In addition, AMO155c-R3V6-GA had higher delivery efficiency than AMO155c-R3V6 micelles. In the comparison of AMO155-R3V6-GA and AMO155c-R3V6-GA, cholesterol moiety of AMO155c increased the stability and delivery efficiency of the ternary micelles. For in vivo evaluation, nebulized AMO155c-R3V6-GA micelle solution were administrated into the lungs of the ALI animal models intratracheally. AMO155c-R3V6-GA micelles had improved AMO155c delivery efficiency, compared with the AMO155c-polyethylenimine complex and AMO155c-R3V6 micelles in the lungs. As a result, SOCS1 expression was increased, and proinflammatory cytokines were reduced in the AMO155c-R3V6-GA micelle groups, compared with the other groups. In conclusion, AMO155c-R3V6-GA ternary micelles may be a useful delivery system for combined therapy of AMO155 and GA for the treatment of ALI.
УЛЬТРАСТРУКТУРНЫЕ ОСОБЕННОСТИ ПАРЕНХИМАТОЗНЫХ КЛЕТОК ИЗМЕНЕННЫХ И НЕИЗМЕНЕННЫХ ТКАНЕЙ ПРИ ПРОЛИФЕРАТИВНОЙ МАСТОПАТИИ
Authors: Э.А. Хыдыров , Н.Н. Исаев , Ш.Ф. Ганбаева
Published: October 2024

В статье представлены результаты исследования, проведенного с целью выявления ультраструктурных особенностей паренхиматозных клеток на различных участках (измененных и неизмененных) тканей при пролиферативной мастопатии. Исследованию были подвергнуты препараты молочных желез 35 женщин (36-60 лет), подвергавшихся оперативному вмешательству. Было использовано электронно-микроскопическое исследование. Исследование показало, что в клетках измененной ткани в верхнем слое эпителиального пласта обладают мелкими цитоплазматическими выростами, а в цитоплазме содержится небольшое количество специфических секреторных гранул, содержащих электронно-плотный секрет и казеиновые тельца. Результаты исследований показали, что в неизмененной ткани выявлены три типа клеток: секреторные, миоэпителиальные и камбиальные. Обнаруженные клетки различаются по ультраструктурным признакам. Выявленные клетки формируют внутридольковые протоки двумя слоями.

Məqalədə proliferativ mastopatiyalı qadınların süd vəzisi toxumasının dəyişiklikliyə uğramış və uğramamış sahələrində yerləşən parenximatoz hüceyrələrin ultrastruktur xüsusiyyətlərini öyrənmək məqsədilə aparılmış tədqiqat işi haqqında məlumat verilmişdir. Tədqiqat obyekti yaşı 35-60 arasında olan 35 xəstədən cərrahi yolla götürülmüş süd vəzisinin biopsiya materialıdır. Süd vəzilərindən hazırlanmış preparatlar elektron-mikroskopik metodla tədqiq edilmişdir. Tədqiqat göstərmişdir ki, dəyişikliyə uğramış toxumada hüceyrələrin epitelial təbəqəsinin üst qatında kiçik sitoplazmatik hündürlüklər, sitoplazmada isə elektron-sıxlıqlı maye və kazein cisimcikləri olan az miqdarda spesifik sekretor qranulalar aşkar edilir. Həmçinin, tədqiqatlar nəticəsində dəyişilməyən toxumada üç tip — sekretor, mioepitelial və kambial hüceyrələr müəyyən edilmişdir. Bu hüceyrələr ultrastruktur xüsusiyyətlərinə görə bir-birindən fərqlənir və paycıqdaxili ikiqatlı axacaqlar təşkil edirlər.

The article presents information about a study conducted to identify the ultrastructural features of parenchymal cells located in altered and unaltered areas of breast tissue in women with proliferative mastopathy. The study involved biopsy material surgically obtained from the breast tissue of 35 patients aged between 35 and 60 years. The prepared specimens from the breast were examined using electron microscopy. The study revealed that the altered tissue in the upper layer of the epithelial sheet cells has small cytoplasmic projections, and the cytoplasm itself contains a small number of specific secretory granules containing electron-dense secretion and casein bodies. Our research results have shown that in the unaltered tissue of the human mammary gland, three types of cells have been identified: secretory, myoepithelial, and cambial. The identified cells differ in ultrastructural features. These cells form intralobular ducts in two layers.
IX Jornadas de Ciencia y Tecnología – III Reunión Argentina-Chile 2024
Authors: Ciencia y Tecnología
Published: October 2024

Las Jornadas de Ciencia y Tecnología Agraria 2024 se desarrollaron los días 26 y 27 de junio de 2024. Se han consolidado institucionalmente por ser las IX Jornadas de la Facultad de Ciencias Agrarias UNR y regionalmente la III Reunión Argentina-Chile, a través de la participación en su organización de las Facultades de Agronomía de la Universidad de Concepción y de Recursos Naturales de la Universidad Católica de Temuco. El formato híbrido de las jornadas permitió que las tres instituciones involucradas compartan diversas experiencias de la ciencia y la tecnología en un ámbito académico, y además discutir los avances de las investigaciones junto a profesionales de Argentina, Chile y otros países interesados de la región.
Las Jornadas incluyeron dos conferencias magistrales, 67 trabajos presentados en formato de poster digital y 8 pósteres presenciales, como también 30 trabajos presentados en tres sesiones orales. Aquí se compendian los resúmenes de las conferencias y los 97 trabajos presentados.
EVALUATION OF THE RESULTS OF THE IMPLEMENTATION OF THE DEVELOPMENT STRATEGY OF THE ORENBURG REGION
Authors:   Orenburg branch of the Institute of economics of the Ural branch of the RAS, Guseva Elena Petrovna , Trubin Sergey Vasilyevich ,   Volga state university of railway engineering (branch)
Published: October 2024

The article discusses the results of the implementation of the development strategy of the Orenburg region. Today, strategic planning extends to all levels of government – federal, regional and municipal. The development of strategies is not just a requirement of legislation, it is also an urgent need for each region individually. Regions are differentiated in terms of resources and development factors, and therefore they play a special role in the development and implementation of socio-economic development strategies. The purpose of this study is to assess the interim results of the implementation of this Strategy at the beginning of 2024 and to develop recommendations related to solving the tasks set in it. The development of the Orenburg region is influenced by both external and internal economic and social factors. External factors include restrictions in the economy due to the changed external conditions caused by international sanctions (restrictions), including a reduction in imports and withdrawal of foreign partners from the Russian market, loss of export markets, delays in the restructuring of production and logistics chains, the need to reorient supplies, lower prices for Russian exports, problems in mutual settlements, as well as high uncertainty in the development of the global economy and the possible tightening of sanctions. The internal factors influencing the trends of socio-economic development of the Orenburg region in the medium term include an insufficient level of investment in fixed assets, a low level of innovation, including digital technologies, lean production tools aimed at increasing labor productivity, increased competition with other regions in terms of attracting investors, as well as demographic a situation characterized by negative dynamics of natural and migratory population growth.
FINANCIAL RESULTS OF THE ORGANIZATION: ENSURING ECONOMIC SECURITY WITH THE USE OF ACCOUNTING AND ANALYTICAL SUPPORT
Authors:   Voronezh institute of economics and law, Davydova Elena Yuryevna , Zolotarev Evgeny Sergeevich ,   Voronezh institute of economics and law, Luschik Timofey Yuryevich ,   Voronezh institute of economics and law, Styagov Sergey Valeryevich ,   Voronezh institute of economics and law
Published: October 2024

When forming the financial results of organizations, an important aspect is to maintain economic security at a sufficiently high level. In order to achieve this, it is necessary to conduct permanent analysis and forecasting of various types of threats, both external and internal, as well as various risks. It should be added that the provision of accounting and analytical support comes to the fore, since it allows you to increase control and show the actual level of achievement of planned results. If the desired result is obtained, the company notes an increase in profits. The resulting profit, in turn, allows you to replenish the financial resources of the organization and create the basis for expanding production (service provision) capabilities, as well as meet the financial and social needs of staff and management. It should be noted that profit is a kind of indicator that allows you to assess the cost recovery, return on capital, sales level, etc. This paper reveals the various points of view of Russian scientists on the definition of "financial result", examines the factors and conditions that influence it. The emphasis is placed on the fact that an important aspect of increasing the effectiveness of stability in the field of national economy and the growth of sustainability is the application and subsequent modernization of the accounting and analytical support system. The author's classification of threats to the economic security of an enterprise is given, based on the study of the works of economists conducting research in this field. The connection of accounting and financial reporting with the economic security of the enterprise is established. At the end of the study, it is concluded that the way the accounting and analytical system is organized affects the economic security of individual enterprises and institutions, and the social and economic spheres of the state, and hence the economy in the world. In this regard, accounting policy plays a significant role in shaping the financial results of organizations, therefore it is necessary to permanently analyze its impact and, if necessary, make adjustments.
MODERN TRENDS IN LABOR PRODUCTIVITY GROWTH IN RUSSIA
Authors:   Saratov state medical university named after V.I. Razumovsky of Ministry of health of the Russian Federation, Efremova Natalia Alexandrovna , Shadchenko Natalia Yuryevna ,   Volga cooperative institute (branch) of the Russian university of cooperation, Shaposhnikova Irina Vladimirovna ,   Moscow financial and industrial university «Synergy»
Published: October 2024

The set growth rates of the Russian economy require the development and implementation of new approaches and tools for the implementation of the national development strategy. One of these tools is the growth of labor productivity. As a multifactorial category, labor productivity is achieved by the best use of all factors of production, machinery, technology, the human factor, organization and management processes. Labor productivity is one of the most important indicators of economic efficiency, the country's GDP is formed under the influence of labor productivity, and a number of economic and social tasks are being solved. For businesses, labor productivity is a measure of the efficiency and well-being of both owners and staff. Today, labor productivity growth is influenced by automation and digitalization, improvement of production and management organization, and better use of the human factor. Ensuring a steady rate of labor productivity growth, the state is implementing an appropriate national project, without which it will be problematic to achieve the goals of sustainable development. The article presents the results of the analysis of labor productivity growth trends in Russia. The problem of labor productivity growth is being solved at the state level through the implementation of the national project "Labor Productivity" by creating favorable conditions for productivity growth, involving the subjects of the country and enterprises in this process. The key trends in productivity growth are related to the optimization of processes at the enterprise, modernization and digitalization of equipment and technologies, increasing staff employment time and improving their skills. The study revealed shortcomings in the implementation of the national project and deepening trends in labor productivity growth, which makes it possible to develop measures to eliminate them.
THE ROLE OF UNIVERSITY COMPLEXES IN THE SOCIO-ECONOMIC DEVELOPMENT OF THE COUNTRY'S REGIONS
Authors:   National Research University ", Leyman Evgeny Nikolaevich ,   MEI", Miroslavskaya Marianna Vladimirovna ,   Baltic State Technical University "VOENMEKH" name after D.F. Ustinov
Published: October 2024

Education plays an important role in the development of the socio-economic system. It not only generates qualified specialists, but also has a strong influence on the economic, political and social development of the regions. In modern conditions, education is becoming a real tool for the qualitative development of the country and increasing its economic potential. For a more accurate understanding of the role of university complexes in socio-economic development, the task of a comprehensive assessment of the main aspects of their contribution to the development of the regions of our country is urgent. The article examines how university complexes contribute to scientific research, the development of innovations and the creation of new technologies. The article analyzes exactly how university complexes act as incubators for startups and young entrepreneurs. Attention is also paid to attracting investments, specialists and talented youth. The cultural role of university complexes is also not ignored. The authors consider the impact on socio-economic development of key trends in education, namely digitalization and mobility. The evolution of the roles played by university complexes is noted. They go beyond traditional knowledge transfer and become active participants in socio-economic and regional governance. Thanks to their multifaceted activities, universities play a key role in creating a favorable economic environment and ensure the sustainable development of both individual regions and our country as a whole. The article focuses on the fact that education is not just a process of acquiring knowledge and skills, but rather a unifying force capable of transforming the socio–economic sphere of the regions of our country.
REALIZATION OF THE EDUCATIONAL FUNCTION OF TEACHING IN ENGLISH LESSONS
Authors:   Secondary School No 135 with in-depth study of english in the vyborg district of St. Petersburg, Pin Olga Leonidovna
Published: October 2024

This article examines the problem of implementing the educational function of teaching in English lessons and describes the author's special course on the study of English-language literature in grades 5-11, designed for students of schools with in-depth study of the English language. The author deals with the issues of the relationship between education and learning, including in historical retrospect, the purpose of education, the importance of the educational function of learning, the educational potential of the subject "Foreign language", reading and its specifics in foreign language lessons, the principles and criteria for selecting a work, forms and methods of working with it, the problems of adapting the text for low levels and the realization of its linguistic potential, the difficulties and opportunities associated with the study of foreign language literature. In particular, a variant of the adaptation of a literary work at different years of study is presented, illustrating the possibility of gradually deepening the penetration into the text – from a short highly adapted retelling to the original. Presenting the program of the special course, the author first gives its general characteristics, and then presents the material of each year of study. This part briefly describes the features of psychological development and the level of knowledge of students in each year of study, on the basis of which a number of works are proposed for study for this academic year and possible methods, techniques and forms of work with these works are outlined.