bluuebunny/crossref_metadata_2025 huggingface dataset:
The model of influencer and customer reviews impact on customer’s purchase intention in the context of sustainable development
Authors:   STIE Indonesia Banking School, Puspita Ivana , Komara Edi ,   STIE Indonesia Banking School, Kusniawati Aini ,   Galuh University, Tabrani  ,   Pancasakti University, Surjaatmadja Surachman ,   Indonesia Defence University
Published: September 2023

In this research, we seeks to replicate and build upon prior study models. Influencer reviews carry more weight than customer reviews when it comes to purchase intention due to trust, statistics, and perceived value, as suggested by a recent study. However, statistics on customer reviews do not appear to make much of an impact. Generally, before making a purchase, prospective buyers shop around and gather information to make informed decisions. eWOM (electronic word-of-mouth) is a go-to source of trustworthy information. Both influencer reviews and customer reviews are categorized as eWOM. Our study is conducted to determine more influential reviews, examining the opinions of 100 respondents. Split into two groups of fifty (50), the participants are either influencer or customer reviewers. All aged between 17-40 and students by occupation. Data analysis has been performed using SEM-SmartPLS 3.0. Sample selection was based on purposive random sampling. In analyzing variables such as eWOM, trust, statistics, perceived value and purchase intentions for sustainable development, this research aimed to identify the more impactful reviews - those from customers or influencers. Ultimately, the data value from influencer reviews proved higher than customer reviews, indicating their dominance in this area.
Organizational happiness character and lecturer performance: the mediating effect of organizational citizenship behavior
Authors:   Winaya Mukti University, Agustina Granit , Ahman Eeng ,   Indonesia University of Education, Disman  ,   Indonesia University of Education, Sojanah Janah ,   Indonesia University of Education, Soeratin Boyke Setiawan ,   Bina Nusantara University
Published: September 2023

This study aimed to determine the role of organizational happiness character (OHC) towards lecturer performance with organizational citizenship behaviour as a mediation variable. The study was aimed to lecturers at private universities in Greater Bandung, with a total number of 5,435 lecturers out of 21 Private Universities. Data was collected using a questionnaire with a differential semantic scale in 2021 and 2022. It has met the minimum sample requirement needed for SEM-PLS analysis. The study is devoted to analiysis of the lecturer perception of organizational happiness, organizational citizenship behavior (OCB), and lecturer performance, testing 4 hypotheses. The measurement scale in this study uses differential semantics which is an effective measurement tool for attitudes. The analysis of the research hypothesis shows a relationship between OHC and performance, and OCB variables affect the improvement of lecturer performance. The relationship between OHC and OCB has also been confirmed and shows a positive and significant relationship. Hence, it can be said that the variable OCB is a mediator for the effect of the variable OHC on employee performance. In this study, organizational citizenship has a partial mediating effect in improving lecturer performance.
The study of pilgrimage in aspects of the economy of tourism organization
Authors:   International Islamic Academy of Uzbekistan, Astanakulov Olim , Sanjar Goyipnazarov ,   Tashkent State University of Economics, Nasurova Kamolakhon ,   Tashkent Financial Institute
Published: September 2023

The relevance of the work. At the beginning of the XXI century, when the service sector becomes a priority, various types of tourism are actively developing. Among them, religious tourism also occupies a worthy place, which, in our opinion, is a promising area of research. All over the world there are a huge number of religious buildings that are distinguished by historical, cultural and sacred and artistic attractiveness. Sacred objects can be visited all year round, regardless of weather conditions, religion, political ambitions and other reasons. Religious tourism as a scientific direction requires a theoretical basis and the development of a methodological base. The purpose of the work is economic analysis of religious tourism as part of tourism system with a special accent on Turkey. One of the most significant findings relates to the efficacy of integrated development plans initiated by the Turkish government for the Antalya region. This rational policy has led to a substantial increase in state revenues from the tourism industry, tallying at USD 33.3 billion in 1987. The study elucidates how the strategic regulation of foreign investment through integrated plans has not only optimized state revenues but also sustainably developed these resort towns into significant tourism hubs. The global pilgrimage tourism economy has been burgeoning as well, with a CAGR of approximately 8% from 2010-2020, reaching a net market valuation of around USD 60 billion. When dissected further, the data reveal that accommodation services constitute about 30% of the total revenue generated, followed by transportation services at 25%, and miscellaneous expenditures covering the remaining 45%. It unambiguously demonstrates that with meticulous planning and strategic investment, pilgrimage tourism has the potential to become a cornerstone in the diversification and enrichment of national and global tourism economies.
On the need to improve federal legislation in terms of clarifying and fixing the legal status of junior medical personne.
Authors:   Expert on the issues of regulatory and legal regulation of health care activities, Piven D. V. , Kitsul I. S. ,   Irkutsk State Medical Academy of Postgraduate Education – the branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation
Published: September 2023

Currently, in the legislation of the Russian Federation, the legal status of persons from among the junior medical personnel in terms of classifying them as medical workers is not clearly defined. This is due to the fact that junior medical personnel do not pass the accreditation of a specialist and, in accordance with the requirements of Part 1 of Art. 69 of the Federal Law of November 21, 2011 No. 323-FZ “On the Fundamentals of Protecting the Health of Citizens in the Russian Federation” (hereinafter referred to as the Fundamentals) does not have the right to carry out medical activities. This circumstance significantly reduces the social security of junior medical personnel and requires mandatory legal correction. The article presents a detailed analysis of the legislation, which substantiates in detail the need to clarify and consolidate the legal status of junior medical personnel. To this end, the legislator is invited to state part 1 of Art. 69 of the Fundamentals as follows: “Persons who have received medical or other education in Russian organizations engaged in educational activities and who have been accredited by a specialist, as well as persons filling other positions of medical workers specified in the nomenclature of positions, have the right to carry out medical activities in the Russian Federation medical workers and pharmaceutical workers, approved by the authorized federal executive bodies.
Review of the state of dental care to the children’s population of the Tver region for the period 2016–2020.
Authors:   Tver State Medical University of the Ministry of Health of Russia, Zhukova K. V. , Konovalov O. E. ,   “Peoples’ Friendship University of Russia”
Published: September 2023

Taking care of the health of the population of the Tver region is an important area of social regional policy. The main task of the dental service of the Tver region is to preserve and strengthen the health of citizens of the Tver region, increase the role of prevention of dental diseases, form a model of the organization of the dental industry, ensuring the availability and quality of dental care, improving the efficiency of dental services, the volumes, types and quality of which should correspond to the level of morbidity and the needs of the population, advanced achievements of medical science. P u r p o s e . To review statistical data on the provision of dental care to children in public institutions of the Tver region. M a t e r i a l s a n d m e t h o d s . The review, analysis, collection and comparison of aggregated data for 2016–2020 in Tver and the Tver region were carried out: statistical data on demography, analysis of dental service performance indicators, analysis of indicators of accessibility of dental care to the children’s population by questioning parents/legal representatives of children’s patients, analysis of personnel potential and questioning of dentists in the profile “Pediatric dentistry”. R e s u l t s . This article is devoted to an overview of the activities of public health institutions of the Tver region providing dental care to the children’s population within the framework of compulsory medical insurance. The results of the study indicate that the prevalence of dental caries among children of the Tver region is consistently high. Further preventive programs and additional research are needed to improve the dental health of children.
Regulatory and legal regulation of medical care in day hospitals.
Authors:   Branch of the Military Medical Academy named after S. M. Kirov of the Ministry of Defense of the Russian Federation, Demyankov K.B. , Yakushev D. Yu. ,   Branch of the Military Medical Academy named after S. M. Kirov of the Ministry of Defense of the Russian Federation
Published: September 2023

The program of state guarantees provides for a reduction in the amount of inpatient care due to the development of inpatient forms and planning an increase in part of the state’s expenses for outpatient care. The correct organization of medical care using hospital replacement technologies is possible only if the requirements of regulatory documents are met. This will allow faster implementation of the main provisions of the Health Concept for the development of hospital replacement forms. Day hospitals are organized in order to improve the organization and improve the quality of medical care in outpatient settings, as well as to increase the economic efficiency of medical organizations through the introduction and widespread use of modern resource-saving medical technologies for prevention, diagnosis, treatment and rehabilitation, which is achieved by following the regulatory documents discussed in the article.
Behavioural risk factors for chronic noncommunicable diseases in health care workers.
Authors:   Northern State Medical University, Shelygin K. V. , Menshikova L. I. ,   Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russian Federation,   Penza Institute for Advanced Medical Training – a branch of the Russian Medical Academy of Continuing Professional Education, Son I. M. ,   Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russian Federation,   Penza Institute for Advanced Medical Training – a branch of the Russian Medical Academy of Continuing Professional Education
Published: September 2023

Low physical activity, smoking and alcohol consumption are among the leading behavioural factors contributing to high morbidity and excess mortality from noncommunicable diseases. It can be assumed that health-care workers should be in the mainstream of population behavioural patterns. However, greater awareness of both the principles of healthy lifestyles and the harms of not following them may distinguish this population group in terms of behavioural responses. Purpose: to estimate the prevalence of behavioural risk factors for chronic noncommunicable diseases among health-care workers. Materials and methods. Study type: case-control study. Data source: results of the survey of the 28th wave of the Russian National Research University Higher School of Economics’ Monitoring of Economic Situation and Health, representative sample by individuals, survey year 2019. Responses received from respondents – health care workers about their use of tobacco, alcohol and exercise were analysed comparatively. Pearson Chi-square test at significance level p≤0,05 was used to find differences. Results. A sociological survey of 55 male and 257 female health workers of working age was carried out. We found that the incidence of a positive smoking response was lower in both male and female working-age health professionals than in the general population of working-age individuals. Compared with the general populations of men and women, no significant differences were found in responses to questions about alcohol consumption and exercise. Findings. We found that of the three behavioural factors (smoking, alcohol consumption, physical activity), only the first was significantly less prevalent among health professionals. The overall trends identified need to be investigated in more detail.
Methodology for developing medical expert systems using graph databases and ontological approach.
Authors:   Department of medical Cybernetics and Informatics named after S. A. Gasparyan of the Pirogov Russian National Research Medical University, Osmolovsky I. S. , Zarubina T. V. ,   Department of medical Cybernetics and Informatics named after S. A. Gasparyan of the Pirogov Russian National Research Medical University
Published: September 2023

Expert systems are a complex software system that accumulates the knowledge of specialists in specific subject areas and disseminates this empirical experience for consultations with less qualified users, which reduces the number of medical errors caused, in particular, by a lack of specialist doctors in local areas and the time required for a single consultation. P u r p o s e of the study is to present a modern methodology for developing expert systems based on knowledge engineering using an ontological approach and graph databases. M a t e r i a l s a n d m e t h o d s . System analysis methods were applied during the creation of the methodology for developing expert systems, including analytical and descriptive methods, knowledge engineering methods such as structuring methods, knowledge representation, and fuzzy logic. The methodology assumes the use of a graph database as a storage for the knowledge base. R e s u l t s . The methodology describes the process of developing expert systems based on a graph database using an ontological approach. It includes the following components: a knowledge base, an intelligent editor of the knowledge base, a problem solver, and explanation subsystem. The methodology assumes the participation of a group of experts in the development of the expert system, with whom the development of two artifacts is carried out: a terminological database of the subject area and intermediate information objects describing the logic of solving the problem. Both artifacts should be formed automatically using the intelligent solver of the knowledge base, as well as filling the knowledge base, which will facilitate the subsequent maintenance of the knowledge base and keep it up-todate. According to the methodology, the solver and explanation subsystem work with a graph database, which is a means of storing the knowledge base, in order to find the optimal path in which nodes are used to solve the problem of the expert system, for example, supporting a specialist doctor in establishing a preliminary/final diagnosis, and the path is used by the explanation subsystem to argue the proposed solution of the expert system. F i n d i n g s . A methodology for creating expert systems using a graph database and an ontological approach has been developed and presented. The methodology describes the development of two components: a knowledge base and a combined component consisting of a solver and an explanation subsystem.
Real-time forecasting model development work plan
Authors: Messina Francesca , Georgiou Ioannis , Baustian Melissa , Dahl Travis , Ryder Jodi , Miner Michael , Heath Ronald
Published: September 2023

The objective of the Lowermost Mississippi River Management Program is to move the nation toward more holistic management of the lower reaches of the Mississippi River through the development and use of a science-based decision-making framework. There has been substantial investment in the last decade to develop multidimensional numerical models to evaluate the Lowermost Mississippi River (LMMR) hydrodynamics, sediment transport, and salinity dynamics. The focus of this work plan is to leverage the existing scientific knowledge and models to improve holistic management of the LMMR. Specifically, this work plan proposes the development of a real-time forecasting (RTF) system for water, sediment, and selected nutrients in the LMMR. The RTF system will help inform and guide the decision-making process for operating flood-control and sediment-diversion structures. This work plan describes the primary components of the RTF system and their interactions. The work plan includes descriptions of the existing tools and numerical models that could be leveraged to develop this system together with a brief inventory of existing real-time data that could be used to validate the RTF system. A description of the tasks that would be required to develop and set up the RTF system is included together with an associated timeline.
Applied Well Test Interpretation
Authors: Spivey John P. , Lee W. John
Published: September 2023

Well test interpretation, which is the process of obtaining information about a reservoir by analyzing the pressure transient response caused by a change in production rate, plays a very important part in making overall reservoir-management decisions. From the authors of Pressure Transient Testing and Well Testing , Spivey and Lee introduce the readers of Applied Well Test Interpretation to the fundamentals of this critical piece of decision-making by focusing on the most basic well testing scenario; a single-well test on a well producing a single-phase fluid, from a single-layer, homogeneous reservoir.
The Grass is Always Greener: Analyzing Crime Concentration and Specialization in Urban Greenspace Environs
Authors: Hodgen Ch. , Wuschke K.
Published: September 2023

Objective: to identify the level of crime in urban greenspaces  and their correclation with certain crime types.

Methods: dialectical approach to cognition of social phenomena, allowing to analyze them in historical development and functioning in the context of the totality of objective and subjective factors, which predetermined the following research methods: formal-logical and sociological.

Results: greenspaces play an important role in the urban landscape, with prior research suggesting that they are associated with numerous health and social benefits for residents. Despite this, research conflicts regarding the relationship between greenspaces and crime, with some studies finding these locations to be criminogenic and others finding them to be protective against local crime. This study examines this relationship in Portland, Oregon, considering different greenspace types as well as different crime types.

Scientific novelty: this study presents a novel methodological adaption to measure crime concentration and specialization around discrete location types by integrating a street network buffer into the standard Location Quotient (LQ) metric. Results suggest that Portland’s greenspaces as a whole do not experience a concentration of crime; however, varying patterns emerge when examining different greenspace and crime types. This study identifies diverse crime concentrations in proximity to small parks, while finding other greenspace categories to be associated with crime-specific concentrations nearby. Others, still, have lower than expected counts of crime concentrating nearby, potentially demonstrating protective trends. These results highlight the importance of disaggregating both crime and location types to better understand the complex relationship between greenspaces and crime.

Practical significance: the main provisions and conclusions of the article can be used in scientific, pedagogical and law enforcement activities when considering the issues related to minimizing crime on the territory of urban green spaces.

 

The article was first published in English language by Criminology, Criminal Justice, Law & Society and The Western Society of Criminology Hosting by Scholastica. For more information please contact: CCJLS@WesternCriminology.org

For original publication: Hodgen, Ch., & Wuschke, K. (2023). The Grass is Always Greener: Analyzing Crime Concentration and Specialization in Urban Greenspace Environs. Criminology, Criminal Justice, Law & Society, 24(1), 19–37.

Publication URL: https://ccjls.scholasticahq.com/article/73940-the-grass-is-always-greener-analyzing-crime-concentration-andspecialization-in-urban-greenspace-environs
Exploring Potential Hindering Factors of NPO Fundraising Activities in a War Environment - Using a Modified Z-HISA Hybrid Model
Authors: Chang Chia-Chi , Pai Chun-Jui , Lin Chia-Hua
Published: September 2023

War poses serious threats to people's property and lives. When war occurs, many countries and non-profit organizations (NPOs) automatically launch fundraising activities to assist in the resettlement and rescue of refuges. However, NPOs often face many barriers in the fundraising process that prevent them from providing the necessary assistance to refuges in a timely manner. It is an important task to develop an evaluation framework to identify the hindering factors of fundraising activities. Therefore, this study proposes a novel hybrid evaluation model called Z-numbers Heterogeneous Influence and Strength Attenuation (Z-HISA), which aims to identify the 12 hindering factors of NPO fundraising activities, to examine the strength of these hindering factors and the positive and negative relationships among them, as well as to generate influence weights. The method takes into account the uncertainty of the experts' answers and measures the experts' confidence level, which is more in line with the experts' actual evaluation. The study used the influence classification map (ICM) to categorize the hindering factors of fundraising into four categories: core, driving, independent, and influence, to suggest management implications and improvements for NPO fundraising activities and to increase donors' willingness to give. The results show that a lack of an appealing fundraising theme, a lack of confidence in NPOs, and poor copywriting planning are the most common hindering factors of fundraising activities. Identifying these fundraising hindering factors can help NPOs develop fundraising strategies and improvement basis for fundraising, thereby increasing their fundraising success. On the academic side, we propose a novel hybrid model evaluation framework and methodological concepts that can be applied to other industries or related fundraising issues.
Contrasting carbon cycle along tropical forest aridity gradients in W Africa and Amazonia
Authors: Zhang-Zheng Huanyuan , Adu-Bredu Stephen , Duah-Gyamfi Akwasi , Moore Sam , Addo-Danso Shalom , Ibrahim Forzia , Amissah Lucy , Valentini Riccardo , Djagbletey Gloria , Anim-Adjei Kelvin , Owusu-Afriyie Kennedy , Gvozdevaite Agne , Ruiz-Jaen Maria , Girardin Cecile , Rifai Sami , Dahlsjö Cecilia , Riutta Terhi , Deng Xiongjie , Tang Minxue , Sun Yuheng , Prentice Iain , Menor Imma Oliveras , Malhi Yadvinder
Published: September 2023

Tropical forests cover large areas of equatorial Africa and play a significant role in the global carbon cycle. However, there has been a lack of in-situ measurements to understand the forests’ gross and net primary productivity (GPP and NPP) and their allocation. Here we present the first detailed field assessment of the carbon budget of multiple forest sites in Africa, by monitoring 14 one-hectare plots along an aridity gradient in Ghana. When compared with an equivalent aridity gradient in Amazonia using the same measurement protocol, the studied West African forests generally had higher GPP and NPP and lower carbon use efficiency (CUE). The West African aridity gradient consistently shows the highest NPP, CUE, GPP, and autotrophic respiration at a medium-aridity site, Bobiri. Notably, NPP and GPP of the site are the highest yet reported anywhere in the tropics using similar methods. Widely used data products (MODIS and FLUXCOM) substantially underestimate productivity when compared to in situ measurements, in Amazonia and especially in Africa. Our analysis suggests that the high productivity of the African forests is linked to their large GPP allocation to canopy and semi-deciduous characteristics , which may be a result of a seasonal climate coupled with high soil fertility.
Visualising nanoscale bias-induced degradation in halide perovskite solar absorbers
Authors: Ducati Caterina , Orri Jordi Ferrer , Iqbal Affan , Yang Terry , Doherty Tiarnan , Selby Thomas , Chiang Yu-Hsien , Anaya Miguel , Allen Christopher , Stranks Samuel
Published: September 2023

Halide perovskite absorbers show enormous potential for next-generation photovoltaic technologies, yet fundamental material degradation mechanisms under operation remain poorly understood. Here, the operational degradation mechanisms in formamidinium-rich (FA-rich) perovskite solar absorbers are studied at the nanoscale through correlative and in-situ electron microscopy techniques, unveiling a rich interplay between charge-carrier-mediated redox reactions and ion segregation under electrical bias. We observe the formation of a degradation front near the positive contact that we ascribe to iodide oxidation and migration. At the opposite contact we see the effects of lead reduction. Alloyed perovskite compositions exhibit more widespread degradation correlated to the presence of nanoscale defective phases and halide heterogeneity, with the microstructure orientation playing a role in the nucleation of phase impurities, carrier transport and transformation under bias. The multi-electrode design biasing platform employed here uniquely enables the selective decoupling of hole- and electron-mediated degradation processes, allowing direct insights into the response of halide perovskite thin films to electrical bias, and the resulting degradation pathways. This fundamental understanding of the electrochemical behaviour of hybrid absorbers will inform strategies for enhanced stability in perovskite optoelectronic devices.
A Multidisciplinary Non-Invasive Approach to Monitor Response to Intravenous Immunoglobulin Treatment in Neurodegenerative Langerhans Cell Histiocytosis: A Real-World Study.
Authors: Trambusti Irene , Barba Carmen , Mortilla Marzia , Rizzi Susanna , Romano Katiuscia , Coniglio Maria Luisa , Lucenteforte Ersilia , Favre Claudio , Guerrini Renzo , Sieni Elena
Published: September 2023

Background: Early detection and treatment of neurodegenerative Langerhans cell histiocytosis (ND-LCH) have been suggested to prevent neurodegenerative progression. The aim of the study is to validate a standardized multidisciplinary diagnostic work-up to monitor the intravenous immunoglobulins (IVIG) treatment response and the natural course of the disease in untreated patients.
Methods: Patients with abnormal somatosensory evoked potentials (SEPs) received monthly 0.5 g/kg IVIG. The diagnostic protocol included structural 3T MRI, neurological examination, brainstem auditory evoked potentials (BAEPs) and SEPs.
Results: Twenty-two patients were enrolled and followed for 5.2 years (median) from the first MRI evidence of ND-LCH. Eleven patients were treated with IVIG for 1.7 years (median). At treatment initiation neurological examination was abnormal in 10 patients, of whom two had severe clinical impairment and four had abnormal BAEPs. At last follow-up, 1/11 remained stable and 7/11 improved, while worsening of neurological or neurophysiological findings, or both, occurred in 3/11. Risk factors for worsening were a severe clinical or MRI ND-LCH at treatment initiation and prolonged exposure to LCH. Of the 11 untreated patients, none improved and three worsened.
Conclusions: Using a standardized diagnostic protocol, we demonstrated that IVIG treatment can lead to clinical stabilization or improvement in all pauci-symptomatic patients with an MRI grading of less than 4.
MAlCO3 Based Layered Double Hydroxides for Catalytic Depolymerization of Poly(ethylene terephthalate) and Poly(bisphenol A carbonate) Waste Materials
Authors: Kumari Sonika , Soni Savita , Sharma Ajay , Sharma Varruchi , Sehgal Bikramjit Singh , Sharma Anil Kumar
Published: September 2023

Polyesters are most frequently used engineering polymeric materials however, polyethylene terephthalate (PET) and polycarbonate (PC) are vastly used polymers and considered as the valuable polymers for the production of fibres, containers, building materials, eyeglass lenses, CDs, DVDs, computer appliances, sports safety equipment. Because of their good tensile strength, thermal stability, chemical resistance and processability, which lead to continuous growth in their demand for widespread applications. The environmental accumulation, high resilience, and fast disposal with degradation/reusability/recycling of these plastics, have given rise to a global concern. The research has been laid in the development of methods for the recycling of these materials are important from environmental protection and resource sustainability point of view. In the present study, the catalytic depolymerization of PET and PC waste accomplished using MAlCO3 based layered double hydroxides (LDHs) and ethylene glycol (EG) into bis(2-hydroxyethyl terephthalate) (BHET) and bisphenol A (BPA) as the main products, respectively. The different type of LDHs combinations synthesized by substitution of different divalent metal ions (MAl-CO3 LDHs where M= Ni/Zn/Mg/Ca/ Co/Cu/Li/Pb/Cd/Mn) through co-precipitation method and characterized by using XRD, FTIR and SEM-EDX techniques. The reaction conditions for the catalytic glycolysis such as the amount of catalyst, solvent, reaction time, and crystallization time have been studied. Furthermore, the recyclability of catalysts has also been investigated. The obtained products after catalytic depolymerization have been identified and characterized using melting point apparatus, thin layer chromatography, 1H-NMR, 13C-NMR and mass spectroscopy. The catalytic performance of LDHs combinations as Zn ˃ Mn ˃ Li, Pb > Cd > Mg > Ni > Co > Ca > Cu has been observed in case of PET while, only ZnAl-CO3 LDH showed catalytic activity in degradation of PC. The catalysts are reusable more than 4 cycles in both case of depolymerization processes without any significant decrease in the activity. The yield of BHET and BPA were observed 79.34 % and 89.07 %, respectively. This work mainly highlighted a sustainable way to design efficient, stable, eco- friendly and recyclable catalysts for PET and PC waste glycolysis into value added products.
Health professions students' learning style preferences and perceptions
Authors: Garvey Graham , Wang Niping , Griggs Jason , Bain Jennifer , Lott James
Published: September 2023

Background
Learning styles can be categorized as either active or passive. Passive learning occurs when knowledge is transferred to the student by an expert, while active learning requires the student to be engaged in the process of knowledge creation. When different learning styles are combined, for example when lectures are looked at online before actively discussing these concepts in class this is integrated learning. This study assessed students' preferences for learning styles and their perception of active learning techniques in the health professions.
Methods
A survey with closed and open-ended questions was administered anonymously to all students at the University of Mississippi Medical Center (UMMC) using Qualtrics™. The data from completed surveys were analyzed.
Results
Of the participants, 63% reported that they learn more effectively through active learning as opposed to passive learning. Learning tools such as working problems, study guides, and class discussions were rated as the most helpful. In contrast, reading articles was least helpful. While the majority of respondents (60%) believed that their school’s teaching styles adequately prepared them for board exams and the future workforce, many students expressed disengagement with their schools’ educational approach.
Conclusions
These findings suggest that health professions students at UMMC prefer active learning styles. Incorporating active learning techniques like problem-solving and class discussions enhance student engagement and learning outcomes in the health professions.
Atomistic Origins of Resurrection of Aged Acetylcholinesterase by quinone methide precursors
Authors: Ferreira Leonardo V. F. , Santos Taináh M. R. , Tavares Camila A. , Ramalho Teodorico C.
Published: September 2023

Nerve agents are organophosphates (OP) that act as potent inhibitors of acetylcholinesterase (AChE), the enzyme responsible for the hydrolysis of acetylcholine. After inhibition, a dealkylation reaction of the phosphorylated serine, known as aging of AChE, can occur. When aged, reactivators of OP-inhibited AChE are no longer effective. Therefore, the realkylation of aged AChE may offer a pathway to reverse AChE aging. In this study, molecular modeling was conducted to propose new ligands as realkylators of aged AChE. We applied a methodology involving docking and quantum mechanics/molecular mechanics (QM/MM) calculations to evaluate the resurrection kinetic constants and ligand interactions with OP-aged AChE, comparing them to data found in the literature. The results obtained confirm that this method is suitable for predicting kinetic and thermodynamic parameters of ligands, which can be useful in the design and selection of new and more effective ligands for AChE realkylation.
Elevated Serum Aldosterone Levels in Patients with Psoriasis and Systemic Arterial Hypertension: A Cross-Sectional Study
Authors: Pinheiro Jennifer , Silva Jose , Duarte Gleison , Daltro Luise
Published: September 2023

Background
Epidemiological studies suggest a higher prevalence of systemic arterial hypertension (HTN) and other cardiovascular diseases in patients with psoriasis. The underlying mechanism remains unclear, but may involve activation of the renin-angiotensin-aldosterone system (RAAS). This study aimed to compare renin and aldosterone levels between psoriasis patients and non-psoriasis individuals.
Methods: A prospective, cross-sectional study enrolled consecutive patients from a university hospital’s dermatology outpatient clinic. Clinical evaluation was followed by blood collection for renin and aldosterone measurement, allowing for comparison between psoriasis and non-psoriasis patients. Subgroup analyses stratified participants based on HTN presence. Multiple linear regression analyses identified independent predictors of higher renin and aldosterone levels.
Results: The study included 170 patients (mean age: 55 ± 13 years, 50.6% men, 85.9% non-white), 57.6% having psoriasis and 44.1% having HTN. Mean plasma renin levels were similar in psoriasis and non-psoriasis patients (26.3 ± 51.4 versus 23.9 ± 48.7 µUI/ml, respectively, p = 0.764). However, psoriasis patients showed significantly higher mean serum aldosterone levels (25.3 ± 49.4 versus 11.7 ± 10.7 ng/dl, p = 0.009). Stratification revealed that only psoriasis patients with HTN had significantly higher aldosterone levels compared to other subgroups. In multiple linear regression analyses, psoriasis was only associated with higher levels of aldosterone in hypertensive patients.
Conclusions: This study indicates elevated serum aldosterone levels in patients with psoriasis and HTN. Further investigation is necessary to understand the potential impact of this finding on cardiovascular morbidity and mortality in psoriasis patients.
The Charts of Radius Stage Adjusted Height-for-age and Weight-for-age Growth Curves of Children and Adolescents
Authors: Zhang Shao-yan , Zhang Miao
Published: September 2023

Objective To develop charts of percentile of height-for-age and weight-for-age adjusted by radial stage for provide a tool for evaluating the growth and development of children with "advanced" and "delayed" maturity.
Methods The sample of 15598 healthy children (boys 7733, girls 7865) aged 3-19 years were from the “The Skeletal Development Standards of Hand and Wrist for Chinese Children-China 05”. The radius stage (RS) of was evaluated by TW grading standard. The correlation coefficients between height and weight and RS, as well as between chronological age and height and weight within RS were calculated. Box-Cox power exponential distribution model was used to calculate the radius stage adjusted (RSA) height-for -age and weight-for -age percentile curve. Using Matlab, RSA height-for-age and weight-for-age percentile curves were superimposed on Height and weight standardized growth chares for Chinese children and adolescents aged 0 to 18 years.
Results During the growth period, height and weight of children were significantly correlated with radial developmental stages (RS). Within RS, the chronological age of children was significantly correlated with their height and weight, but the correlation coefficient decreased with the increase of RS. Twenty-eight RSA height-for-age and weight-for-age growth charts were obtained by calculating percentile curves of height and weight within the radius stage. The adjustments for height and weight were smaller by the RSA charts during childhood, and larger in adolescence.
Conclusion RSA height -for-age and weight-for-age growth charts provide a useful tool for adjusting the results of assessment in “advanced” and “delayed” children and adolescents.
Association between hypertension and gingival bleeding: a two-sample Mendelian randomization study
Authors: Liu Sheng-hui , Fu Ling-ling , Ye Bin , Ao Man , Gosau Martin , Friedrich Reinhard E. , Smeets Ralf , Yan Ming , Feng Hong-chao , Burg Simon , Feng Hong-chao
Published: September 2023

Objectives To investigate whether there is a causal relationship between hypertension and gingival bleeding using Mendelian randomization analysis.
Materials and methods We performed a two-sample two-way Mendelian randomization (MR) analysis using publicly released genome-wide association study (GWAS) statistics. The inverse variance weighting (IVW) method was used as the primary analysis. We applied complementary methods, including weighted median, weighted mode, simple mode, MR-Egger regression, and MR-polyvalence residuals and outliers (MR-PRESSO) to detect and correct for the effects of horizontal polyvalence.
Results IVW MR analysis showed a causal relationship between hypertension and gingival bleeding (IVWOR =1.0056, P =0.0171). Similarly, a significant causal relationship between gingival bleeding and hypertension was found in the inverse MR analysis (IVW OR = 4.7645, P = 0.0012). The results of the MR-Egger regression method, weighted median method and weighted plural method were consistent with the IVW method. Based on sensitivity analysis, horizontal multiplicity is unlikely to distort causal estimates.
Conclusions Although some observational studies have reported no causal relationship between gingival bleeding on hypertension or hypertension on gingival bleeding, the results of our MR analysis support a causal relationship between hypertension and gingival bleeding.
Clinical relevance Mendelian randomization studies can analyze more clearly whether there is a causal relationship between hypertension and gingival bleeding, with a view to providing some reference for clinicians, deepening their understanding of the relationship between hypertension and gingival bleeding, and exploring more possible associations between hypertension or gingival bleeding and systemic diseases.
Prevalence of COVID-19 home remedy consumption among adult population in Brunei Darussalam: A cross-sectional study
Authors: Zaim Siti Nurzaimah Nazhirah , Rahman Hanif Abdul , Idris Deeni Rudita
Published: September 2023

Background: The Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV-2 affects the respiratory system and causes severe acute respiratory infections. Several cultures have influenced the use of home remedies to ease mild symptoms of COVID-19 sometimes alongside conventional medicine. The aim of this study was to investigate the usage of COVID-19 home remedies among the adult population in Brunei.
Methods: The study design was a cross-sectional study using an online survey and distributed nationwide. The statistical analysis of the data included descriptive statistics describing the sociodemographic characteristics of the respondents, their experience with COVID-19 infection, consumption of general home-remedies and COVID-19 home remedy, their practice of COVID-19 home-remedy use, and their attitude towards the general use of home-remedy. Sub-group analysis including chi-square test was computed for the variables in relation to the COVID-19 home remedy use and the perceived effectiveness of the types of home remedy. Multivariate analysis including Partial Least Squares Structural Equation Modelling (PLS-SEM) was applied to determine the correlations between the factors and outcomes measured. P-value less than 0.05 is considered statistically significant.
Results: There was a total of 864 eligible responses included in the study. The primary findings showed COVID-19 home remedy was used by 72.2% of the study participants. Most frequently used types of COVID-19 home remedy were cloves (37%), lemon (37%), and honey (23%), there was an infrequent usage of coconut (4.6%), eucalyptus oil (3.7%), habbatussauda (3.5%), traditional/ herbal cough syrup (2.4%), and turmeric (2.2%). The PLS-SEM demonstrated that ‘Experience’ appears to be a central endogenous variable that affects the decision on the use of COVID-19 home remedy. This relationship is mediated by ‘Safety’, ‘Source’, and ‘Opinion’ which have significant contributions to the outcome, accounting for 98.2% of the variance explained (R-square = 0.982).
Conclusions: The outcome of this study establishes the baseline prevalence of COVID-19 home remedy consumption among Bruneian residents and compared the previous study on Brunei’s general use of traditional medicine. The present findings could help nurses and other healthcare professionals in Brunei understand the practice of Bruneian adults on the consumption of home remedies for COVID-19.
Multi-Epigenome-Wide Analyses and Meta-Analysis of Child Maltreatment in Judicial Autopsies and Intervened Children and Adolescents
Authors: Tomoda Akemi , Nishitani Shota , Fujisawa Takashi , Takiguchi Shinichiro , Yao Akiko , kazuhiro Murata , Hiraoka Daiki , Mizuno Yoshifumi , Ochiai Keiko , Kawata Natasha , Makita Kai , Saito Daisuke , Mizushima Sakae , Suzuki Shizuka , Fujioka Toru , Kurata Sawa , Ishiuchi Naoki , Taniyama Daiki , Nakao Naoki , Namera Akira , Okazawa Hidehiko , Nagao Masataka
Published: September 2023

Child maltreatment (CM) leads to adverse outcomes in later life. We describe the epigenome-wide analyses and meta-analysis results of three original cohorts consisting of judicially or socially certified CM cases and controls to gain further insight into the epigenetic signatures engraved in maltreated children. We also show associations with biological indicators (endophenotypes) in each cohort that represent CM features with maltreatment history, thus providing further confidence in the identified methylations. Four methylations in ATE1, CHST11, SERPINB9P1, and FOXP1 associate with CM in the meta-analysis, in addition to several genome-wide level significant methylations in each cohort. FOXP1, a gene related to neurodevelopmental disorders, is of particular interest, as its methylation level correlates with atypical brain structures representing in maltreated children and contributes to the accuracy of a methylation risk score to predict CM. These results suggest that severe CM experiences may contribute to neurodevelopmental-like and traumatic symptoms via epigenetic alterations.
Interplay Between Element-Specific Distortions and Electrocatalytic Oxygen Evolution for Cobalt-Iron Hydroxides
Authors: Smith Rodney , Alsaç Elif , Boke Marlyn , Bissonnette Justine
Published: September 2023

A microscopic understanding of how Fe-doping of Co(OH)2 improves electrocatalytic oxygen evolution remains elusive. We study two Co1-xFex(OH)2 series that differ in fabrication protocol and find composition poorly alone correlates to catalyst performance. Structural descriptors extracted using X-ray diffraction, X-ray absorption spectroscopy, and Raman spectroscopy reveal element-specific distortions in Co1-xFex(OH)2. These structural descriptors are composition-dependent within individual sample series but inconsistent across fabrication protocols, revealing fabrication-dependence in catalyst microstructure. Correlations between structural parameters from different techniques show that Fe-O resists bond length changes, forcing distortion of Co environments. We find the difference in O-M-O bond angles between Co and Fe sites to correlate to the electrocatalytic behavior across both sample series. This unifying descriptor supports activation of a lattice-oxygen mechanism by decreasing O-O distance and will assist ongoing efforts to design next-generation catalysts. The fabrication dependence of microscopic catalyst structure should be considered in theoretical and high-throughput analyses of electrocatalyst materials.
The role of the SIRT1-BMAL1 pathway in regulating oxidative stress in the early development of ischaemic stroke
Authors: 诗 静 , 里 伟荣 , 叮 小波 , 周 冯 , 浩 陈熙 , 他 苗族人 , 王 电风扇 , 里 信义
Published: September 2023

Oxidative stress is the primary cause of ischaemic stroke and is closely related to circadian rhythm. However, the mechanism by which circadian rhythm regulates oxidative stress in ischaemic stroke remains elusive. The Silent Information Regulator 1 (SIRT1) controls circadian rhythm by activating the transcription of the circadian clock core protein Basic Helix-Loop-Helix ARNT Like 1 (BMAL1) through deacetylation. Studies have shown that the SIRT1-BMAL1 pathway can regulate oxidative stress. To investigate its correlation with oxidative stress, we examined the expression levels and influencing factors of SIRT1-BMAL1 at different times in ischaemic stroke patients and analyzed their clinical indexes, oxidative stress, and inflammatory factor indicators. The expression levels of oxidative stress and inflammatory factor indicators, including malondialdehyde (MDA), superoxide dismutase (SOD), interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-α), SIRT1, and BMAL1, were detected in ischaemic stroke patients within 4.5 hours of onset and in non-stroke patients. Patients were divided into four subgroups based on onset time: subgroup 1 (0:00–05:59); subgroup 2 (06:00–11:59); subgroup 3 (12:00–17: 59); and subgroup 4 (18:00–23:59). Our results showed higher MDA, IL-6, and TNF-αlevels, and lower SOD, SIRT1, and BMAL1 levels in ischaemic stroke patients compared to control patients (P < 0.05). Among the four subgroups, the content of MDA, IL-6, and TNF-αwas highest in patients with ischaemic stroke onset from subgroup 2 (06:00–11:59), while the expression levels of SOD, BMAL1, and SIRT1 were lowest in patients with ischaemic stroke in subgroup 2. Additionally, myeloperoxidase (MPO) reached the highest value showing the same trends consistent with MDA, IL-6, and TNF-α and opposite trends consistent with SOD, BMAL1, and SIRT1. However, triglycerides (TGs), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), immediate blood glucose, immediate diastolic blood pressure, immediate systolic blood pressure, and homocysteine (HCY) did not show any statistically significant circadian rhythm changes (P > 0.05). Our findings suggest that the SIRT1-BMAL1 pathway may be involved in early oxidative stress in ischaemic stroke, which may be related to MPO.