bluuebunny/crossref_metadata_2025 huggingface dataset:
Soluble guanylate cyclase: restoration of the NO–sGC–cGMP signaling pathway activity. A new opportunity in the treatment of heart failure
Authors: Belenkov Yu. N. , Kozhevnikova M. V.
Published: June 2023

Studying the key mechanisms of cardiovascular diseases has opened new possibilities for the pharmacological impact on the pathophysiological mechanisms of heart failure (HF). The signaling pathway, nitric oxide – soluble guanylate cyclase – cyclic guanosine monophosphate (NJ-sGC-cGMP), provides normal functioning of the cardiovascular system in healthy people and serves as a potential target for medicines in HF with reduced ejection fraction (HFrEF). In HFrEF progression, the sGC activity decreases due to endothelial dysfunction and oxidative stress. The increased synthesis of cGMP resulting from sGC stimulation can restrict myocardial fibrosis, reduce stiffness of the vascular wall and induce vasodilation; in this process, the mechanism of action of sGC stimulators does not overlap with other therapeutic targets. According to the results of the international randomized clinical study VICTORIA, the use of the sGC stimulator, vericiguat, in patients with HF, ejection fraction <45%, and a recent episode of decompensation in their history reduced the risk of repeated hospitalization and cardiovascular death. Also, this treatment was characterized by a favorable safety profile when added to standard therapy.
Reflection as the basis of E. Husserl's phenomenological methodology
Authors: Shiyan Anna
Published: June 2023

The article analyses reflection as a methodology of Husserl's phenomenology. Husserl used reflection as a method in his research, but did not always specifically consider it when describing his own methodology. He paid much more attention to essential intuition, epoché (reduction) and intentional analysis. The author develops the thesis that reflection is inextricably linked with these methods and requires special study. The article discusses the specifics of reflexive analysis used in Husserl's phenomenology to study consciousness and solve problems of cognition of the external world. The author takes into account its goals and objectives, which determine the terminological apparatus for fixing its results and are based on a certain understanding of the experience of consciousness.
Reflection as a construct of the Soviet philosophical "Thaw": semantics and pragmatics
Authors: Kuznetsova Natalia I.
Published: June 2023

The article discusses the methodology for studying reflective systems, which are very specific objects of study. However, such objects include almost all phenomena of the socio-humanitarian sciences, including scientific knowledge. It is noted that in the era of the “sixties” original concepts of reflexive analysis arose in Russian philosophy, among which the three most striking ones, associated with the names of V.A. Lefebvre (1936-2020), G.P. Shchedrovitsky (1929-1994), M.A. Rozova (1930-2011). The main attention is paid to the methodology that was built within the framework of the theory of social relay races by M.A. Rosova. It is shown how systems with reflection function and why they are able to rebuild, changing the order of sociality.
ПРАКТИЧНА ОЦІНКА РЕАЛІЗАЦІЇ РОЗПОДІЛЕНОГО КРИПТОАНАЛІЗУ В УМОВАХ ОБМЕЖЕНИХ РЕСУРСІВ
Authors: Носов Віталій , Лучик Василь , Колісник Тетяна , Калякін Сергій , Світличний Віталій
Published: June 2023

Оперативні підрозділи відповідних спеціальних служб і органів державної влади при здійсненні своїх повноважень часто стикаються із задачею здійснення криптоаналізу отриманих зашифрованих даних. На практиці оперативне криптографічне розкриття таких даних зазвичай має дві суттєві обставини: відсутність спеціалізованих обчислювальних ресурсів та наявність лише обмеженої кількості персональних комп'ютерів з ОС Windows. Одним із актуальних способів підвищення ефективності криптоаналізу в таких умовах є реалізація паралельних розподілених клієнт-серверних обчислень  на базі локальної мережі персональних комп'ютерів з ОС Windows, де сервер через деякий інтервал часу розподіляє виділені підмножини простору можливих ключів шифрування між агентами в локальній мережі, які в свою чергу передають задачу перебору ключів відповідній локальній програмі. Здійснений перший етап практичної оцінки застосунку Hashtopolis як інструмента розподіленого криптоаналізу в умовах обмежених ресурсів. Hashtopolis є працездатним у локальній мережі персональних Windows комп'ютерів і може бути використаний на практиці. Зростання швидкості паралельних обчислень не є прямо пропорційним кількості агентів, оскільки витрачається час на формування підмножин простору ключів, їхнього доставлення агентам та отриманням результатів перебору ключів. Практична оцінка Hashtopolis потребує подальшого дослідження зростання продуктивності його роботи у залежності від кількості агентів, інших типів ґешів і типів криптоаналізу (за словником, комбінований) та контролю температури процесорів на агентських машинах. Ідентифікована задача оптимального вибору для агентів розміру підмножини простору можливих ключів в залежності від кількості агентів, їх поточної швидкості перебору, алгоритму ґешу і типу перебору.
Do ESG ratings mediate the relationship between board gender diversity and firm financial performance? Evidence from the U.S. Market
Authors: Nguyen Duy Thanh , Hoang Thinh Gia , Phi Nguyet Thi Minh , Truong Thanh Hai Huyen
Published: June 2023

The impact of board gender diversity on firm value is inconclusive. The paper investigates whether a firm’s environmental, social, and governance (ESG) performance mediates the relationship between board gender diversity and firm financial performance. The study employs a sample of 1514 non-financial firms listed on the National Association of Securities Dealers Automated Quotations (NASDAQ) and New York Stock Exchanges (NYSE) from 2016 to 2020. It reveals that a firm improves its ESG ratings and financial performance when there are more female directors on its board. When controlling ESG performance, the significant relationship between board gender diversity and firm performance turns insignificant, and ESG performance has a significant positive impact on a firm’s financial performance. These findings confirm the mediating role of ESG performance in the studied relationship. A firm’s management can refer to these findings to employ more women on its board, which creates additional firm financial value through better ESG practices. Investors may incorporate the factors of board gender diversity and corporate ESG performance into their investment decisions.
Impact of quarry activities on the air quality around neighbouring localities in Ogun State, Nigeria
Authors: Hassan Isiaka Adio
Published: June 2023

Quarry industry and its products play an important role in any economy in the world. This study examined the impact of quarry activities on air quality around the neighbouring localities in Ogun State. Eight locations were selected; Isara, Idode, Iwaye, Ogbere, Ilagbe, Adelokun, Baaki Ake, and Igodo.  Air quality was assessed for the concentration of CO2, PM2.5 and PM10 using standard procedures. Samplings were carried out in dry and wet seasons. Data were subjected to descriptive and inferential statistics using SAS package (9.4 version), compared with World Health Organisation (WHO) and the probability of particulate matters causing health hazard was also calculated using Air Quality Index (AQI). PM2.5 and PM10 (dry season) of the surrounding locations were higher than the WHO Limits of 15 and 45 µg/m3 respectively; except the PM10 at Iwaye (32.20±4.18 µg/m3), Isara (35.60±4.38 µg/m3) and Adelokun (42.58±2.74).  In wet season, the PM2.5 (all locations) and only PM10 of Ilagbe ((45.99±3.15), Baaki Ake (50.97±3.13) and Igodo (49.68±2.17) were higher than their corresponding WHO Limits. The AQI of PM2.5 (both seasons) at various locations were in the range of 51 – 100 (moderate). AQI of PM10 dry and wet seasons across locations range 0 – 50 (good); except the PM2.5 of Baaki Ake (51.16) hence, moderate. CO2 concentration at Adelokun (421.73±2.75), Baaki Ake (415.62±5.82) and Igodo (411.85±1.95) (dry season) and Adelokun (405.98±2.60) and Baaki Ake (403.26±1.63) (wet season) surpassed WHO limit (400 µg/m3). The surrounding localities were polluted with CO2 and particulate matters (PM2.5 and PM10) with no health hazard.
Educação básica para a democracia
Authors: Perez Cabral Guilherme , Caldeira Ladeira Marina , Cardoso Roldão Taís Helena , Sambrano Amaral Amanda
Published: June 2023

O artigo relata experiências e apresenta resultados de investigações desenvolvidas de forma articulada com o objetivo de aferir repercussões e similaridades entre o conteúdo propugnado pela UNESCO à educação para a democracia em sua interpretação do Direito internacional dos direitos humanos e projetos de lei sobre a temática, no âmbito da educação básica, apresentados na Câmara dos Deputados e Assembleia Legislativa de São Paulo (segundo semestre de 2015 e 2016) e na Câmara Municipal de Campinas (de 2014 a 2018). O recorte temporal remete ao contexto em que a UNESCO direciona seu debate à educação para a cidadania global. No Brasil, ao objetivo constitucional de promoção da cidadania democrática, retomado no Plano Nacional de Educação de 2014, contrapôs-se o avanço de conservadorismo autoritário, culminando na eleição de Jair Bolsonaro em 2018. Por outro lado, na práxis da relação entre educação e democracia, vivemos a mobilização estudantil secundarista com a ocupação de escolas entre 2015 e 2016). À pesquisa empírica documental sobre a atuação do Poder Legislativo, soma-se a análise de conteúdo e a revisão bibliográfica. São trazidos, como resultados e conclusões: a quase ausência de referências à UNESCO e a seus programas nos projetos de lei; ligada à linguagem genérica da organização, a identificação de aproximações – não repercussões – entre suas propostas reformistas e as temáticas abordadas em projetos analisados; a identificação de repercussões da onda conservadora, em projetos orientados ao resgate de cidadania “patriótica” e ao combate à “doutrinação ideológica” da esquerda e à “ideologia de gênero”.
Development of Information Support for Intelligent Control of Urban Rail Transport Systems
Authors: Sidorenko Valentina , Loginova Lyudmila , Safronov Anton
Published: June 2023

The article discusses generalized approaches used in designing information support for intelligent transportation systems, based on the example of a train dispatcher simulator and an automated system for building schedules of passenger trains movement in the Moscow Metro as interrelated systems within a unified technological process of organizing the movement of rolling stock along the lines of the Moscow metro, Moscow Central Circle, Moscow Central Diameters, and the city’s tram network. The article analyzes the existing systems developed by the team of the “Management and Protection of Information” department at the Russian University of Transport (MIIT) for the State Unitary Enterprise “Moscow Metro”, an integral part of which are information systems. Common properties of the systems are identified for information support, and a classification of tables serving as the basis for implementing urban rail transport management systems is proposed. The article lists the properties that the designed information support of the intelligent transport system must possess, and proposes a methodology for its construction. The article presents the structures and functional features of information systems used for building an intelligent transportation system, including the content of databases that serve as a link between the upper interface and lower technical levels. The selection of the database management system is also justified.
Türk Sanatında Kadın Bedeninin İkonografik Açıdan Değerlendirilmesi
Authors: ZENCİRKIRAN Ayşegül , BERKLİ Yunus
Published: June 2023

Tarih öncesi dönemin anaerkil aile düzenine paralel olarak gelişen ana tanrıça kültü, kadının anlamlandırılamayan biyolojik özelliklerinin gizemli/ilahi kabul edilmesi düşüncesi ile oluşmuştur. Bu algının neticesi olarak kadının kutsiyet atfedilen doğum ile bağlantılı organları, sanat eserleri üzerinde vurgulu olarak belirtilmiş olup, Kibele veya Venüs gibi steatopik denilen iri göğüslü ve kalçalı, sarkık göbekli bedenler karşımıza çıkmaktadır. Göbekli tepe ve Tarih öncesi dönemlerin yanı sıra tarihi çağlarda da süregelen bu algı, Türk Kültür ve Sanatına da aksetmiş, söz konusu kadın figürleri, gerek İslamiyet’ten önce gerekse İslami dönemi kapsayan geniş zaman diliminde bu dinin mahremiyet anlayışına rağmen kullanılmıştır. Bu fikrin tam aksi olarak kutsal kökenli kişi ve olayların haricinde halkın üst sınıfına mensup kadınlarının ise hizmetkârları veya cariyelerine nazaran daha kapalı giyindikleri hatta yüz dâhil tüm bedenlerini kapatmanın sadece hanımlara mahsus olduğu anlaşılmaktadır. Konumuz kapsamında Türk Sanatına ait kaya ve duvar resimleri, heykeller, sikkelere yansıyan bu kadın bedenleri değerlendirilecektir.
Preservação digital em repositórios digitais de Instituições Federais de Ensino Superior brasileiras
Authors: Borba Vildeane da Rocha , Lima Fanny do Couto Ribeiro de , Silva Vania Ferreira da
Published: June 2023

Introdução: A humanidade tem experimentado grandes transformações na organização, tratamento e acesso à informação, motivadas pelos avanços das tecnologias digitais e o uso intensivo de tecnologias de informação. Porém, não obstante as vantagens permitidas pelos avanços tecnológicos no tocante ao poder de armazenamento e transferência, a durabilidade e possibilidade de preservação das informações registradas em suportes digitais ainda permanece como desafio a longo prazo. Objetivo: Analisar a relação entre a preservação digital em repositórios digitais de Instituições Federais de ensino superior (IFES) brasileiras em sua documentação institucionalizada. Metodologia: O estudo foi caracterizado como descritivo, de natureza qualitativa e quantitativa, que utilizou enquanto técnica de coleta de dados a análise documental e mineração de texto. Os critérios de investigação se pautaram na contextualização dos termos preservar, preservação e/ou preservação digital, o levantamento das ações, estratégias e práticas de preservação digital e as terminologias adotadas na documentação institucionalizada. Resultados: Percebe-se que os Repositórios digitais das Instituições Federais de ensino superior (IFES) brasileiras não possuem documentos institucionalizados que atendam as especificidades do planejamento de preservação, previsto e sendo um elemento essencial no modelo de referência do Open Archival Information System (OAIS). Conclusão: A Preservação Digital requer planejamento, políticas, planos, recursos humanos e infraestruturas tecnológicas para atender ao princípio de tornar acessível com qualidade de autenticidade os artefatos digitais, dessa forma, para além de inserir o termo preservação digital em seus documentos institucionais, as Universidades precisam tecer documentos específicos para questão da preservação digital.
Indicadores de preservação digital em projetos de Ciência Cidadã
Authors: Silva Fabiano Couto Corrêa da , Umpierre Larissa Weber , Witt Amanda Santos
Published: June 2023

Introdução: A ciência cidadã tem crescido como uma abordagem eficaz para envolver o público na coleta e análise de dados em diversos campos da pesquisa científica. A preservação digital dos dados gerados nesses projetos é crucial para garantir a sustentabilidade e acessibilidade dos recursos para futuras pesquisas e aplicações práticas. Objetivo: Este estudo tem como objetivo propor indicadores e um workflow de preservação digital para projetos de ciência cidadã, com foco em um exemplo prático de monitoramento da qualidade da água. Metodologia: Através de uma revisão da literatura sobre preservação digital e ciência cidadã, identificamos princípios e desafios relevantes e selecionamos indicadores de preservação digital. Com base nesses indicadores, desenvolvemos um workflow para processos de preservação digital em projetos de ciência cidadã. Resultados: Os indicadores selecionados incluem acessibilidade, autenticidade, integridade, interoperabilidade e sustentabilidade. Um workflow de cinco etapas foi desenvolvido, abrangendo coleta e armazenamento de dados, normalização e padronização, preservação e redundância, acesso e compartilhamento, e monitoramento e avaliação. Conclusão: A aplicação dos indicadores e do workflow proposto em projetos de ciência cidadã, como o monitoramento da qualidade da água, pode garantir a preservação eficaz e sustentável dos dados e recursos digitais coletados e gerados, promovendo a colaboração e a inovação na pesquisa científica. A implementação deste workflow e a avaliação contínua dos indicadores podem orientar projetos de ciência cidadã na gestão adequada dos recursos digitais e na promoção do avanço do conhecimento científico.
Preservação digital
Authors: Rezende Laura Vilela Rodrigues , Castanheira Pablo Fernandes , Alves Rômulo Arantes , Cruz-Riascos Sonia Aguiar
Published: June 2023

Introdução: Trata-se de uma análise bibliométrica da produção científica sobre o tema Preservação Digital dada sua relevância na preservação do patrimônio científico, histórico e cultural da humanidade, registrado e armazenado em formato digital. Objetivo: O objetivo deste trabalho é analisar detalhadamente a produção científica sobre Preservação Digital a partir de artigos científicos publicados em periódicos indexados na base de dados Web of Science (WOS) entre o período de 1992 a 2022. Metodologia: Abordagem quantitativa, de caráter descritivo. A bibliometria foi escolhida como técnica de pesquisa por realizar análise quantitativa que se baseia na elaboração de indicadores que proporcionam um melhor delineamento da produção científica sobre o tema. Resultados: A partir da coleta dos dados foram analisados 341 artigos que tratam diretamente do tema. Por meio da análise e interpretação dos dados foi possível verificar o número de artigos publicados ao longo dos anos, quantidade de artigos publicados segundo o idioma, país de origem dos pesquisadores, os periódicos com maior número de publicações, artigos por área do conhecimento, os autores mais produtivos na temática, o número de autores por artigo, os artigos mais citados e a frequência de palavras-chave. Conclusão: Os indicadores bibliométricos elaborados a partir deste estudo contribuem para aprimorar o conhecimento da comunidade científica sobre o tema: Preservação Digital. Acrescenta-se a isso o potencial de abrir caminhos para novas pesquisas, uma vez que um levantamento bem delimitado sobre a produção bibliográfica de uma temática específica facilita demasiadamente o trabalho dos pesquisadores no desenvolvimento de novos estudos com abordagens inovadoras.
Increasing Smartphone Usage Correlates With Worsening Sleep Quality Among Students
Authors: Silalahi Anggi Dearni , Lestari Pudji , Khairina
Published: June 2023

High intensity of gadget usage affects the population. Gadget addiction especially smartphones became more common. Previous studies have shown its negative effects, such as bad sleep quality. This study aims to find the relationship between smartphone usage and sleep quality among medical students. The questionnaires used in this study were AKPP (Asesmen Komunitas terhadap Pengalaman Psikotik), SAS- SV (Smartphone Addiction Scale - Short Version), and PSQI (Pittsburgh Sleep Quality Index). The statistical analysis used in this study were Pearson’s Chi-square and Pearson’s r. This study was an observational cross-sectional study. Among 201 respondents, 126 (62.7%) were at high risk of getting addicted to smartphones and 95 (47%) were having bad sleep quality. This study found that there was a moderate positive correlation between increasing smartphone usage and worsening sleep quality (p = 0.006, r = 0.320). In conclusion, there was a correlation between smartphone usage and sleep quality.
Giving Birth By Caesarean Section in Women Infected With Covid-19 and The Incidence of Covid-19 in Newborn. A Systematic Review
Authors: Pratama Mahardika Nandha , Umiastuti Pirlina , Nisa’ Ayu Imamatun , Suropati Bagus Meurah , Hasanah Rizka Uswatun , Dirda Prasasta Reka Elvia , Fairuz Jihan Jauza , Kalishah Jihan
Published: June 2023

Labor method by caesarean section in Covid-19 infected pregnant women had higher ratio than vaginal delivery. The use of Caesarean section is adjusted to the condition of the mother or/and the baby. However, the literature on labor method and its relation to Covid-19 infection in newborn is rare. We conducted a review about association between giving birth by caesarean section in women infected with Covid-19 and the incidence of Covid-19 in the newborn. This research was an analytic systematic review and guided by PICO. Studies from NCBI and ScienceDirect were used to locate full text articles, written in English, published from 2019-2021. The search strategy included terms for (Cesarean Section or Delivery, Obstetric) and (Covid-19 or Sars-Cov-2) and infant, newborn and infectious disease vertical transmission. Articles were included when met the inclusion and exclusion criteria, then analysed with RevMan 5.4. The search yielded 205 records. After full text screening, 3 studies were found to meet all criteria and 3 studies were obtained from manual search. Six studies using cohort designs were based in the United States, China, Morocco, Spain, and Turkey. Sample sizes ranged from 15 to 125 participants. Overall effect z=0.81 (p value=0.42) showed that the caesarean section had no significant protective factor from Covid-19 infection in newborn. Our finding indicated that babies who were born from mothers with Covid-19 infection. However, there was possible publication bias and samples collected were minimum. More studies are needed to advance this emerging literature.
Blood Pressure and anthropometry obesity indices in first professional medical students at a private medical college of Pakistan-a cross-sectional study
Authors: Zafar Uzma , Usman Ul Haque Muhammad , Jabeen Naeem Faiqa , Sufyan Musfirah , Usman Naeem Muhammad
Published: June 2023

Obesity, a significant public health issue, requires immediate attention to prevent obesity-mediated health concerns such as hypertension, metabolic syndrome, and adverse coronary and circulatory events. The present study aimed to determine blood pressure (BP) and anthropometric obesity indices (including BMI, waist circumference, waist-to-hip ratio, and mid-upper arm circumference) of 1st Professional MBBS students in a private medical college in Pakistan, and also to find the association of BP with anthropometric indices. It was a cross-sectional survey conducted at Lahore Medical and Dental College. Institutional Review Board approval was acquired before the study commencement.  The duration of the study was from May to August 2022. The study population included all students registered in first-year MBBS who agreed to participate in the study. The present study included 120 participants. The mean ± standard deviation (SD) age of participants was 19.05±0.82 years. Mean systolic and diastolic BP was 116.05±13.21 and 74.85±9.81 respectively. Sixty-seven (56%) participants were having their BP ≥ 120/80 and were identified as pre-hypertensive or hypertensive respectively. Mean ± SD BMI was 22.18±4.31 kg/m2; 67 (55.8%) were having normal BMI, 20(16.7%) were overweight and 33 (27.5%) obese. On the basis of waist circumference; 39 (70.9%) male subjects were normal and 16 (29.1%) centrally obese, whereas 47 (72.3%) females were normal and 18 (23.7%) obese. Overall central obese subjects were 35 (29%). Logistic regression analysis was applied; hypertension was taken as a dependent variable and all-other independent covariates such as anthropometry indices (BMI, waist circumference), gender, age, and residential status were controlled; association of hypertension was significant with gender (p=0.001) and waist circumference (p=0.000). Students need to modify lifestyle strategies for preventing obesity and hypertension.
Effect of Hemoglobin Levels and Body Mass Index of Female Workers on Their Work Productivity. A Systematic Review
Authors: Anugraha Surya , Sri Umijati
Published: June 2023

More young women are working than ever before and they contribute a lot to achieving the company's revenue targets. Work productivity is closely related to the incidence of chronic energy deficiency, obesity, and anemia which are still high in young women in Indonesia. This nutritional problem can be identified by assessing the body mass index (BMI), and hemoglobin levels. How is the effect of BMI and Hb levels related to their work productivity? In this systematic review study, work productivity is described based on the number of work attendance and the number of workers able to accomplish their work. The data were collected from primary research results with the help of PubMed, Science Direct, and Research Gate databases. The keywords used were 'Hemoglobin' or 'BMI’ combined with 'Women workers' and 'Productivity'. The data were adjusted to the Selected Reporting Items for Systematic Reviews and the Meta-Analyses chart, and four articles were obtained in which the data were synthesized in a narrative manner. Women workers with obesity were found to be about 20.50%, 2.03% were malnourished and 39.19% were anemic. Productivity and work attendance decreased in those with anemia and low BMI. A person's hemoglobin level and BMI are directly proportional to the productivity level of the women workers.
Infection Prevalence of Soil-Tramsmitted Helminth (STH) at Metal Muslim Al-Hidayah Islamic Boarding School Students, Pasuruan, Indonesia
Authors: Bagus dwi nugraha  , Sri Wijayanti Sulistiawati  , Widati Fatmaningrum
Published: June 2023

Soil-Transmitted Helminth (STH) infection is a national and international health problem. STH infection can inhibit the process of absorption of food so that the body lacks nutrients. Children are the most commonly encountered because of the lack of awareness of maintaining personal hygiene, especially in Islamic boarding schools where children are outside the supervision of parents. This research is a cross-sectional study with an observational descriptive type. The location of this research is Metal Muslim Al-Hidayah Islamic Boarding School, Pasuruan. The study used stool samples from the students which were then examined using the Kato-Katz method. From the results of the study, it was found that the number of students infected with STH was 28 students (68.3%), the infection was known to be of this type of Trichuris trichiura. 18 students (43.9%) had mild infections and 10 students (24.4%) had moderate infections. the most infected students were male with 19 students (46.3%), while according to age the most were at the age of 9 years with 12 students 29.27%. this incident could be due to the activities of students playing outdoors plus a lack of awareness to maintain personal hygiene such as washing hands with soap.
Flipchart and Booklet As Media to Increase Cadre’s Knowledge About Latent Tuberculosis Prevention in Children
Authors: Retno Asih Setyoningrum  , Arda Pratama Putra Chafid  , Rika Hapsari  , Amrina Rosyada  , Muhammad Helmi Imaduddin  , Khoirunnisa Shafira Deshpande  , Nabila Annisa Harum
Published: June 2023

Educating and empowering the community through tuberculosis cadres is crucial in the early detection of latent tuberculosis infection (LTBI) in primary healthcare settings. From the wide variety of educational media that can be used, flipcharts and booklets have a strong impact on engaging the participants through visual media. Therefore, this community service aims to determine the effect of education through flipcharts and booklets on TB cadres to increase LTBI finding in children. A total of 20 TB cadres of Dr. Soetomo Primary Health Care Surabaya participated in this study. Statistical analysis to evaluate the difference between the pre-test and post-test was used with the Wilcoxon test. The result of the pretest showed insufficient knowledge about latent tuberculosis with an average score of 74%.  The post-test average score of 91% indicated a 17% increase in score. There was a significant difference in the score of the test before and after giving the material (p=0.001), indicating an increase in LTBI knowledge of the TB cadres after giving health education using flipchart and booklet as evidenced by the increase in average score between pre-test and post-test.
Evaluation of Stylohyoid Ligament Calcifications in the Central Anatolian Region
Authors: Altındağ Ali
Published: June 2023

This study aims to determine the prevalence of the elongated styloid process (ESP) on panoramic radiographs in a Turkish subpopulation and to investigate the relationship between SP lengths and the age and gender of individuals. Digital panoramic radiographs of 1000 patients who applied to Necmettin Erbakan University, Faculty of Dentistry, Dentomaxillofacial Radiology Clinic for the first examination between January 2020 and January 2022 were obtained from the database and examined. Individuals were evaluated by dividing them into three groups according to their age SP lengths were measured on both sides, and those greater than 30 mm were contemplated elongated. The data were evaluated in the SPSS V.21 program. In 1000 evaluated patients, ESP of >30 mm was detected in 304 individuals. It was determined that SP length did not differ according to age groups, gender, and systemic disease (p<0.05). Panoramic radiographs are useful, economical, and easily reachable diagnostic equipment in the diagnosis of symptomatic or asymptomatic ESP. Furthermore, it would be more useful to evaluate the prevalence of ESP with larger sample groups and advanced imaging methods.
Machine learning accelerated discovery of high transmittance in (K0.5Na0.5)NbO3-based ceramics
Authors: Ma Bowen , Yu Fangyuan , Zhou Ping , Wu Xiao , Zhao Chunlin , Lin Cong , Gao Min , Lin Tengfei , Sa Baisheng
Published: June 2023

High optical transmittance (T%) has always been an important indicator of transparent-ferroelectric ceramics for optoelectronic coupling. However, the pathway of pursuing high transparency has been at the experimental trial-and-error stage over the past decades, manifesting major drawbacks of being time-consuming and resource-wasting. The present work introduces a machine learning (ML) accelerated development of highly transparent-ferroelectrics by taking potassium-sodium niobate (KNN)-based ceramics as the model material. It is highlighted that by using a small data set of 118 sample data and four key features, we predict the T% of un-synthesized KNN-based ceramics and evaluate the importance of key features. Meanwhile, the screened (K0.5Na0.5)0.956Tb0.004Ba0.04NbO3 ceramics were successfully realized by the conventional solid-state synthesis, and the experimental measured T% is in full agreement with the predicted results, exhibiting a satisfactory high T% of ~78% at 800 nm. In addition, ML is also used to explore the best experimental parameters, and the prediction results of T% are particularly sensitive to changes in sintering temperature (ST). Eventually, the predicted optimal ST is highly consistent with the experimental one. This study constructs a new avenue for exploring high T% ferroelectric KNN ceramics based on ML, ascertaining optimal process parameters, and guiding the development of other transparent-ferroelectrics in optoelectronic fields.
The Influence of Glycerol Flow through a Shielded Coil on an Enzyme Placed Near Its Side
Authors: Ivanov Yuri D. , Shumov Ivan D. , Kozlov Andrey F. , Ershova Maria O. , Valueva Anastasia A. , Ivanova Irina A. , Tatur Vadim Y. , Lukyanitsa Andrei A. , Ivanova Nina D. , Ziborov Vadim S.
Published: June 2023

Glycerol has found its applications as a heat-transfer fluid in heat exchangers, and as a compo-nent of functional solutions in biosensor analysis. Flowing non-aqueous fluids are known to be able to induce electromagnetic fields due to triboelectric effect. These triboelectrically generated electromagnetic fields can affect biological macromolecules. Horseradish peroxidase (HRP) is widely employed as a convenient model object for studying how external electric, magnetic, and electromagnetic fields affect enzymes. Herein, we have studied whether the flow of glycerol in a ground-shielded cylindrical coil affects the HRP enzyme incubated at a 2 cm distance near the coil’s side. Atomic force microscopy (AFM) has been employed in order to study the effect of glycerol flow on HRP at the nanoscale. Increased aggregation of HRP on mica has been observed after the incubation of the enzyme near the coil. Moreover, the enzymatic activity of HRP has also been affected. The results reported can find their application in biotechnology, food technology and life sciences application, considering the development of triboelectric generators, en-zyme-based biosensors and bioreactors with surface-immobilized enzymes. Our data can also be of interest for scientists studying triboelectric phenomena.
Analysis of Arbitrarily Loaded Rectangular Thin Plates with Two Opposite Edges Supported, One or Both of them Clamped, Using the Flexibility Method and a Modified Lévy Solution
Authors: Fogang Valentin
Published: June 2023

This paper aims to analyze arbitrarily loaded isotropic rectangular thin plates with two opposite edges supported (simply supported or clamped), from which one or both are clamped, and the other edges have arbitrary support conditions. Rectangular thin plates with two opposite edges simply supported are routinely analyzed using for the deflection the simple trigonometric series of Lévy or the double trigonometric series of Navier, while the loads are expanded in Fourier series. In this paper the flexibility method (or force method) of the linear beam theory was applied whereby the unknowns were the bending moments along the opposite edges; in this regard, the primary system was the plate simply supported along the above-mentioned opposite edges and subjected to the external loads, system solved using the Lévy solution, and the redundant system was the plate simply supported along the opposite edges and subjected to bending moments along those edges. In the redundant system, a modified Lévy solution was introduced to account for the edge moments. The compatibility equations (vanishing of the slopes at selected positions of the opposite edges) were set to determine the unknowns and so the efforts in the plate. The results obtained were in good agreement with the exact results.
Flexible Curcumin-Loaded Zn-MOF Hydrogel for Long-Term Drug Release and Antibacterial Activities
Authors: Jiaxin Li , Yachao Yan , Yingzhi Chen , Qinglin Fang , Irfan Hussain Muhammad , Lu-Ning And Wang
Published: June 2023

Management of chronic inflammation and wounds has always been a key issue in the pharmaceutical and healthcare sector. Curcumin (CCM) is an active ingredient extracted from turmeric rhizomes that has antioxidant, anti-inflammatory, and antibacterial activities, thus showing significant effectiveness toward wound healing. However, its shortcomings such as poor water solubility, poor chemical stability and fast metabolic rate limit its bioavailability and long-term use. In this context, hydrogels appear to be a versatile matrix for carrying and stabilizing drugs due to the biomimetic structure, soft porous microarchitecture, and pleasant biomechanical properties. The drug loading/releasing efficiencies can also be controlled by use of highly crystalline and porous metal organic frameworks (MOFs). Here, a flexible hydrogel composed of sodium alginate (SA) matrix and CCM-loaded MOFs was constructed for long-term drug release and antibacterial activity. The morphology and physicochemical properties of composite hydrogels were analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), ultraviolet visible spectroscopy (UV-Vis), Raman spectroscopy and mechanical property tests. The results showed that the composite hydrogel was highly twistable and bendable to mechanically comply with human skin. The as-prepared hydrogel could capture efficient CCM for slow drug release as well as effective killing of bacteria. Therefore, such composite hydrogel is expected to provide a new management system for chronic wound dressings.
Hydraulic Response and Overtopping Performance of Single-Layer Double-Cube Unit Armored Mound Breakwater
Authors: Safari Iman , Mouazé Dominique , Aliasgary Soroush , Carpentier Guillaume , Ropert François
Published: June 2023

The newly developed friction-interlocking armor unit, called ‘Double cube’ (DC), has been designed to improve the performance of the concrete armor unit used in river/marine structures against currents/waves actions. DC unit, is an octagonal-shaped block, made up of two parts: an upper cube set on a lower base that is either square or octagonal in shape. The innovative design aims to provide a good performance in terms of stability, high tolerance placement with various contact points and ease of placement. DC’s shape and placement enhance the stability by bringing the center of gravity closer to the underlayer and providing a large contact surfaces with surrounding blocks that reduce the chance of extraction and limit movements (rocking, lifting) via "keystone" effect. The characteristics of this new unit provides a relatively high hydraulic stability number for the armor layer (NS=2.9), a favorable hydraulic performance due to energy dissipation from turbulence and aeration, as well as a high roughness coefficient (γf≈0.46) helping to reduce the overtopping.
Effects of Physical Activity Program on Body Composition, Physical Performance, and Neuromuscular Strategies During Walking in Older Adults With Sarcopenic Obesity: Randomized Controlled Trial
Authors: FERHI Hamza , GAIED CHORTANE Sabri , DURAND Sylvain , BEAUNE Bruno , BOYAS Sebastien , MAKTOUF Wael
Published: June 2023

The potential impact of a specific physical activity program on biomechanical gait parameters and neuromuscular strategies around the ankle joint in older adults with sarcopenic obesity (SO) remains largely unexplored. The objective of this study was to investigate the effectiveness of a 24-week Posture, Strengthening, and Motricity (PSM) program in improving neuromuscular strategies and biomechanical gait parameters in older adults with SO. 40 Participants were randomly assigned to either the trained group (TG) and the control group (CG). Only the TG received the PSM program. Standardized evaluations were performed before and after the intervention, including walking tests on an instrumented gait analysis treadmill to evaluate biomechanical gait parameters and EMG activity of ankle muscles. After the PSM program, TG exhibited an increase in comfortable walking speed (+80%, p<0.001) and step length (+38%, p<0.05). Moreover, TG demonstrated a reduction in CoP velocity (-26%, p<0.01). These gait modifications were associated with a decreased muscle activity during the different gait phases (p<0.05). The PSM program effectively improved gait, and neuromuscular capacities in older adults with SO. Notably, Results sheds light on the remarkable trainability of neuromuscular capacities in older adults with SO, despite the adverse effects of aging and obesity.
Study on Factors Influencing Moisture Susceptibility of Warm Mix Asphalt Using the Surface Free Energy Approach
Authors: Liu Liping , Liu Lingxiao , Yu Ying
Published: June 2023

The application of warm-mixing technology brings considerable economical and environment benefits by decreasing the mixing temperature during warm asphalt mixture(WMA) production. However, the possible water residue also generates concerns in moisture susceptibility. For deep investigation on the influencing factors and mechanism of the moisture susceptibility of WMA, surface free energy(SFE) test and laboratory tests are applied in this research. A novel indicator based on SFE namely effective adhesion work is proposed to assess the asphalt-aggregate adhesion with different moisture contents. Then, given the mixing procedure of dry mixing method, an advanced three-phase model as form of asphalt-aggregate-warm mixing additive is introduced improving from the conventional two-phase asphalt-aggregate model for better reflecting the separate addition of warm mixing additive during mixing. Afterwards, the influence of aggregate types, asphalt type, aggregate moisture contents, warm-mixing agent types and warm-mixing process on the moisture susceptibility of WMA is analyzed utilizing the models and indicators proposed. Finally, the validity of the SFE indicator is verified by comparing the calculation of effective adhesion work with freeze-thaw splitting test result. The results show that all of the above factors impact the moisture susceptibility of WMA by influencing the interfacial adhesion, with the effect of moisture content being the most significant. Meanwhile, effective adhesion work and the three-phase model brought out in this research are proven to be feasible to characterize the adhesion properties of WMA, offering theoretical support to the research on warm mixing technology.
Comparative Clinical Performances of Tunneled Central Venous Catheter Versus Arterio-Venous Accesses in Patients Receiving High Volume Hemodiafiltration: The Case for High-Flow DualCath, a Tunneled Two Single Lumen Silicone Catheter
Authors: Canaud Bernard , Leray-Moragues Hélène , Chenine Leila , Morena-Carrere Marion , Miller George , Canaud Ludovic , Cristol Jean-Paul
Published: June 2023

Tunneled central venous catheters (CVC) are mainly considered as rescue vascular access option in dialysis but still used in about one quarter of prevalent patients worldwide as being associated with poor performances and higher risks.
Study design. In this retrospective single-center study, we aimed to report on clinical performances achieved with high-flow tunneled CVC (DualCath, DCath) and compared it with arteriovenous accesses (AVAs; AV fistula, AV graft, Thomas Shunt) in a hospital-based dialysis unit.
Methods. Sixty-eight stage 5 chronic kidney disease dialysis dependent patients (CKD5D) receiving high volume hemodiafiltration were followed-up for 30 months.
The study consisted of two phases: baseline cross-sectional and longitudinal follow-up of key performance indicators. Clinical performances consisting of effective blood flow and blood volume, recirculation, urea and ionic Kt/V and total Kt, ultrafiltration volume and percent reduction of ß2-M were measured monthly as part of quality control in our unit.
Results. At baseline, effective blood flow with DCath was close to 400 ml/min, similar to AVAs. Recirculation with DCath (7%, 6-13%) was higher than AVAs. Diffusive dialysis dose delivered with DCath (spKt and eKt/V) and convective dialysis dose achieved with DCath were slightly lower than AVAs, but still much higher than recommended by guidelines. Percent reduction of ß2-M achieved with DCath was also 4 to 10% lower than AVAs. On longitudinal follow-up, main clinical performance indicators of DCath (total Kt and total ultrafiltration volume, L/session) were maintained very stable over time and close to those achieved with AVAs.
Conclusions. As shown in this study, high-flow DualCath tunneled two single lumen silicone catheters may be used to deliver high volume hemodiafiltration in a reliable and consistent manner without compromising clinical performances. These results rely from the specific design of the two silicone cannulas and the strict adherence to best catheter practices.
Effect of Increase in Staples on Financial Resilience in F&B Companies
Authors: Mutiara Sari Fannya , Nugraheni C.R Putri , Nadia Kristy Henitha
Published: June 2023

Rising raw material prices can have a significant impact on the financial performance of the food and beverage (F&B) business. The purpose of this study was to determine the impact of rising prices of staples onfinancial resilience F&B business in Indonesia. This study uses a quantitative approach with bivariate correlation analysis and secondary data from the financial reports of F&B companies listed on the Indonesia Stock Exchange for the 2020-2022 period. The results showed that the increase in the price of basic commodities had a significant positive impact onfinancial resilience F&B company. This can be seen from the decline in the profitability and liquidity of F&B companies as a result of the increase in the price of basic commodities. Therefore, F&B companies must pay attention to and manage the risk of rising prices of basic commodities to maintainfinancial resilience and sustainable business continuity.
Solder Alloy Design: Investigation of Predictive Models for Tensile Properties Based on Different Alloy Compositions and Microstructures
Authors: Silva Vítor Covre Evangelista da , Gouveia Guilherme , Silva Bismarck Luiz , Tomazella Vera Lucia Damasceno , Spinelli José Eduardo
Published: June 2023

In this study, an extensive data set was based on existing literature records in order to enable the suitability of several predictive models, from Multiple Linear Regression (MLR) to Neural Networks (NN). The main objective was to, through regression analyses, generate model computations to correlate tensile properties (UTS- Ultimate Tensile Strength, YTS – Yield Tensile Strength and EF – Elongation-to-Fracture) to a given alloy composition and microstructural spacing. This investigation led to positive results, as the highest accuracies of the trained modules (in 80% of the database) were found to be above ~82% (UTS and EF) and a maximum of ~98% (YTS), when analyzing the results to a test data set. Later, these models were used to define trends for possible next solder alloy commercial compositions. Overall, using the standard model’s setup, the Random Forest and Decision Tree models showed the highest accuracy results, with 0.958 for YTS as opposed to 0.907 for MLR. Moreover, Multilayer Perceptron (MLP)-optimized models yielded the best results for each variable, with the highest increases in accuracy associated with the YTS and EF. The present contribution might imply an important milestone towards alloy design research based on data science guidelines to unlock the full potential of former experiments and their extensive set of results.
Using DEMATEL and ISM to Design Green Public Policies Based on the System of System Approach
Authors: Teymourifar Aydin , Trindade Maria A. M.
Published: June 2023

In this paper, we propose a novel approach to the development of green public policies. We emphasize the significance of the System of Systems (SoSs) methodology, which concentrates on understanding and managing complex systems by contemplating their interdependencies and interactions as a single integrated system. Based on this perspective, we view green public policy as a system interacting with the energy, health, pollutants, and economic systems of the SoSs. We employ both Decision-Making Trial and Evaluation Laboratory (DEMATEL) and Interpretive Structural Modeling (ISM) techniques as a method of systematic structural analysis to comprehend the relationships between the aforementioned systems. We provide a comprehensive literature review on the application of these soft operation research (SOR) techniques. We note that SOR methods are suitable for the formulation of effective and long-lasting public policies. Using an example, we demonstrate the primary advantage of DEMATEL and ISM, which is the establishment of easily comprehendible causal relationships between the systems in the SoSs.