bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiple sclerosis under the age of ten: the challenge of a rare diagnosis in a special population – a case series
Authors: Carvalho Inês V. , dos Santos Constança Soares , Amaral Joana , Ribeiro Joana Afonso , Pereira Cristina , Pais Rui Pedro , Palavra Filipe
Published: December 2023

Introduction

Multiple sclerosis (MS) is a chronic inflammatory demyelinating and degenerative disease of the central nervous system which, when it begins before the age of 18, is defined as paediatric MS. Most common clinical presentations include long tract involvement, brainstem/cerebellum syndromes, optic neuritis and acute disseminated encephalomyelitis. Paediatric-onset MS typically has a more inflammatory-active course and a higher lesion burden in imaging studies, but an extensive post-relapse recovery, with a slower long-term disability progression. The first demyelinating clinical attack occurs before 10 years old in less than 1% of patients, and, in this special population, the condition has particularities in clinical presentation, differential diagnosis, diagnostic assessment, current treatment options and outcome.

Clinical cases

We present the cases of four Caucasian children (2 girls) diagnosed with relapsing–remitting MS before the age of ten, with a mean age at the time of the first relapse of 7.4 ± 2.4 years. Clinical presentation included optic neuritis, myelitis, brainstem syndrome, and acute disseminated encephalomyelitis. Baseline MRI identified several lesions, frequently large and ill-defined. Two patients were included in clinical trials and two patients remain in clinical and imaging surveillance.

Conclusion

Diagnosis of MS before the age of 10 years is rare, but it has significant long-term physical and cognitive consequences, as well as a substantial impact on the current and future quality of life of the child and family. Early and correct diagnosis is essential. Prospective, randomized, large cohort studies are needed to assess the efficacy and safety of disease-modifying treatments in children under the age of ten.
Gut microbiota alterations are associated with functional outcomes in patients of acute ischemic stroke with non-alcoholic fatty liver disease
Authors: Yu Gaojie , Chen Qionglei , Chen Jiaxin , Liao Xiaolan , Xie Huijia , Zhao Yiting , Liu Jiaming , Sun Jing , Chen Songfang
Published: December 2023

Introduction

Patients with acute ischemic stroke (AIS) with non-alcoholic fatty liver disease (NAFLD) frequently have poor prognosis. Many evidences suggested that the changes in gut microbiota may play an important role in the occurrence and development of AIS patients with NAFLD. The purpose of this study was to explore microbial characteristics in patients of AIS with NAFLD, and the correlation between gut microbiota and functional outcomes.

Methods

The patients of AIS were recruited and divided into NAFLD group and non-NAFLD group. The stool samples and clinical information were collected. 16 s rRNA sequencing was used to analyze the characteristics of gut microbiota. The patients of AIS with NAFLD were followed-up to evaluate the functional outcomes of disease. The adverse outcomes were determined by modified Rankin scale (mRS) scores at 3 months after stroke. The diagnostic performance of microbial marker in predicting adverse outcomes was assessed by recipient operating characteristic (ROC) curves.

Results

Our results showed that the composition of gut microbiota between non-NAFLD group and NAFLD group were different. The characteristic bacteria in the patients of AIS with NAFLD was that the relative abundance of Dorea, Dialister, Intestinibacter and Flavonifractor were decreased, while the relative abundance of Enorma was increased. Moreover, the characteristic microbiota was correlated with many clinical parameters, such as mRS scores, mean arterial pressure and fasting blood glucose level. In addition, ROC models based on the characteristic microbiota or the combination of characteristic microbiota with independent risk factors could distinguish functional dependence patients and functional independence patients in AIS with NAFLD (area under curve is 0.765 and 0.882 respectively).

Conclusion

These findings revealed the microbial characteristics in patients of AIS with NAFLD, and further demonstrated the predictive capability of characteristic microbiota for adverse outcomes in patients of AIS with NAFLD.
Tyrosine Kinase Inhibitors in pediatric chronic myeloid leukemia: a focused review of clinical trials
Authors: Ata Fateen , Benkhadra Maria , Ghasoub Rola , Fernyhough Liam J. , Omar Nabil E. , Nashwan Abdulqadir J. , Aldapt Mahmood B. , Mushtaq Kamran , Kassem Nancy A. , Yassin Mohamed A.
Published: December 2023

Tyrosine Kinase Inhibitors (TKIs) is revolutionizing the management of pediatric Chronic Myeloid Leukemia (CML), offering alternatives to Allogeneic Hematopoietic Stem Cell Transplantation (AHSCT). We conducted a comprehensive review of 16 Randomized Controlled Trials (RCTs) encompassing 887 pediatric CML patients treated with TKIs including Imatinib, Dasatinib, and Nilotinib. The median patient age ranged from 6.5 to 14 years, with a median white blood cell count of 234 x 10^9/uL, median hemoglobin level of 9.05 g/dL, and median platelet count of 431.5 x 10^9/µL. Imatinib seems to be predominant first line TKI, with the most extensive safety and efficacy data. BCR::ABL response rates below 10% ranged from 60% to 78%, CCyR at 24 months ranged from 62% to 94%, and PFS showed variability from 56.8% to 100%, albeit with differing analysis timepoints. The Safety profile of TKIs was consistent with the known safety profile in adults. With the availability of three TKIs as first line options, multiple factors should be considered when selecting first line TKI, including drug formulation, administration, comorbidities, and financial issues. Careful monitoring of adverse events, especially in growing children, should be considered in long term follow-up clinical trials.
Prostate transmembrane androgen inducible protein 1 (PMEPA1): regulation and clinical implications
Authors: Zhu Qicui , Wang Yue , Liu Yaqian , Yang Xiaoke , Shuai Zongwen
Published: December 2023

Prostate transmembrane androgen inducible protein 1 (PMEPA1) can promote or inhibit prostate cancer cell growth based on the cancer cell response to the androgen receptor (AR). Further, it can be upregulated by transforming growth factor (TGF), which downregulates transforming growth factor-β (TGF-β) signaling by interfering with R-Smad phosphorylation to facilitate TGF-β receptor degradation. Studies have indicated the increased expression of PMEPA1 in some solid tumors and its functioning as a regulator of multiple signaling pathways. This review highlights the multiple potential signaling pathways associated with PMEPA1 and the role of the PMEPA1 gene in regulating prognosis, including transcriptional regulation and epithelial mesenchymal transition (EMT). Moreover, the relevant implications in and outside tumors, for example, as a biomarker and its potential functions in lysosomes have also been discussed.
Role of SIRT3 in bone homeostasis and its application in preventing and treating bone diseases
Authors: Xu Ke , Li Jing , Wen Ruiming , Chang Bo , Cheng Yang , Yi Xuejie
Published: December 2023

Bone homeostasis refers to the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption and the maintenance of stable bone mass. SIRT3 is a class of mitochondrial protein deacetylase that influences various mitochondrial functions and is involved in the mechanisms underlying resistance to aging; regulation of bone marrow mesenchymal stem cells, osteoblasts, and osteoclasts; and development of osteoporosis, osteoarthritis, and other bone diseases. Moreover, exercise affects bones through SIRT3. Thus, studies on SIRT3 may provide insights for the treatment of bone diseases. Although SIRT3 can exert multiple effects on bone, the specific mechanism by which it regulates bone homeostasis remains unclear. By evaluating the relevant literature, this review discusses the structure and function of SIRT3, reveals the role and associated mechanisms of SIRT3 in regulating bone homeostasis and mediating bone health during exercise, and highlights the potential pharmacological value of SIRT3 in treating bone diseases.
Chinese herbal compound for multidrug-resistant or extensively drug-resistant bacterial pneumonia: a meta-analysis and trial sequential analysis with association rule mining to identify core herb combinations
Authors: Zhao Shuman , Geng Yanting , Shi Jiaheng , Qian Jing , Yang Yebeilei , Dai Dan , Yan Zimin , Qi Wensheng , Yu Daxing , Zhao Xin
Published: December 2023

Purpose: Antibiotic-resistant bacterial pneumonia poses a significant therapeutic challenge. In China, Chinese herbal compound (CHC) is commonly used to treat bacterial pneumonia. We aimed to evaluate the efficacy and safety of CHC and identify core herb combinations for the treatment of multidrug-resistant or extensively drug-resistant bacterial pneumonia.

Methods: Stata 16 and TSA 0.9.5.10 beta software were used for meta-analysis and trial sequential analysis (TSA), respectively. Exploring the sources of heterogeneity through meta-regression and subgroup analysis.

Results: Thirty-eight studies involving 2890 patients were included in the analyses. Meta-analysis indicated that CHC combined with antibiotics improved the response rate (RR = 1.24; 95% CI: 1.19–1.28; p < 0.0001) and microbiological eradication (RR = 1.41; 95% CI: 1.27–1.57; p < 0.0001), lowered the white blood cell count (MD = −2.09; 95% CI: −2.65 to −1.53; p < 0.0001), procalcitonin levels (MD = −0.49; 95% CI: −0.59 to −0.40; p < 0.0001), C-reactive protein levels (MD = −11.80; 95% CI: −15.22 to −8.39; p < 0.0001), Clinical Pulmonary Infection Scores (CPIS) (MD = −1.97; 95% CI: −2.68 to −1.26; p < 0.0001), and Acute Physiology and Chronic Health Evaluation (APACHE)-II score (MD = −4.08; 95% CI: −5.16 to −3.00; p < 0.0001), shortened the length of hospitalization (MD = −4.79; 95% CI: −6.18 to −3.40; p < 0.0001), and reduced the number of adverse events. TSA indicated that the response rate and microbiological eradication results were robust. Moreover, Scutellaria baicalensis Georgi, Fritillaria thunbergii Miq, Lonicera japonica Thunb, and Glycyrrhiza uralensis Fisch were identified as core CHC prescription herbs.

Conclusion: Compared with antibiotic treatment, CHC + antibiotic treatment was superior in improving response rate, microbiological eradication, inflammatory response, CPIS, and APACHE-II score and shortening the length of hospitalization. Association rule analysis identified four core herbs as promising candidates for treating antibiotic-resistant bacterial pneumonia. However, large-scale clinical studies are still required.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42023410587.
Efficacy of mirabegron for ureteral stones: a systematic review with meta-analysis of randomized controlled trials
Authors: Wang Zhenguo , Chi Junpeng , Liu Yuhua , Wu Jitao , Cui Yuanshan , Yang Chenchen
Published: December 2023

Background: Medical expulsive therapy demonstrates efficacy in managing ureteral stones in patients amenable to conservative interventions. This meta-analysis aims to evaluate the effectiveness of mirabegron in the treatment of ureteral stones.

Methods: From conception to November 2023, we examined PubMed databases, the Cochrane Library, Embase, Ovid, Scopus, and trial registries for this systematic review and meta-analysis. We chose relevant randomized controlled trials (RCTs) evaluating the efficacy of mirabegron as an expulsive treatment for ureteral stones. The Cochrane risk of bias method was used to assess the quality of the evidence. Outcome measures, which included the stone expulsion rate (SER), expulsion time, and pain episodes, were analyzed using RevMan 5.4 and Stata 17.

Results: Seven RCTs (N = 701) had enough information and were ultimately included. In patients with ureteral stones, mirabegron-treated patients had a substantially higher SER [odds ratio (OR) = 2.57, 95% confidence interval (CI) = 1.41–4.68, p = 0.002] than placebo-treated patients. Subgroup analysis revealed that mirabegron was superior to placebo in patients with small ureteral stones (OR = 2.26, 95% CI = 1.05–4.87, p = 0.04), with no heterogeneity between studies (p = 0.54; I2 = 0%). Mirabegron patients had a higher SER than the control group for distal ureteral stones (DUSs) (OR = 2.48, 95% CI = 1.31–4.68, p = 0.005). However, there was no difference in stone ejection time or pain episodes between groups.

Conclusion: Mirabegron considerably improves SER in patients with ureteral stones, and the effect appears to be more pronounced for small and DUSs. Nevertheless, mirabegron treatment was not associated with improved stone expulsion time or pain management.
Visual analysis of commognitive conflict in collaborative problem solving in classrooms
Authors: Lu Jijian , Zhang Yuwei , Li Yangjie
Published: December 2023

In today’s knowledge-intensive and digital society, collaborative problem-solving (CPS) is considered a critical skill for students to develop. Moreover, international education research has embraced a new paradigm of communication-focused inquiry, and the commognitive theory helps enhance the understanding of CPS work. This paper aims to enhance the CPS skills by identifying, diagnosing, and visualizing commognitive conflicts during the CPS process, thereby fostering a learning-oriented innovative approach and even giving the script of technology-assisted feedback practices. Specifically, we utilized open-ended mathematical tasks and multi-camera video recordings to analyze the commognitive conflicts in CPS among 32 pairs, comprising 64 Year 7 students. After selecting the high-quality, medium-quality, and low-quality student pairs based on the SOLO theory, further investigations were made in the discourse diagnosis and visual analysis for the knowledge dimensions of commognitive conflict. Finally, it was discovered that there is a need to encourage students to focus on and resolve commognitive conflicts while providing timely feedback. Visual studies of commognitive conflict can empower AI-assisted teaching, and the intelligent diagnosis and visual analysis of CPS provide innovative solutions for teaching feedback.
Displaying epistemic stance through same-turn self-repair in Chinese civil courtroom interaction
Authors: Xu Jun , Ge Lei
Published: December 2023

Repair, or conversational repair, frequently appears in court proceedings as a vital mechanism sustaining effective communication. Our study presents a conversational analysis of the choices of different operations in the same-turn self-repair and shows how judges, plaintiffs, defendants, and their lawyers deploy those operations based on a model of epistemic stance. The data were drawn from the top five most-viewed videos of Changsha civil courtrooms from March to May, 2019, totaling more than 50,000 words. In the courtroom interaction, replacing and inserting are the most frequently used operations for all participants. In the courtroom cross-examinations, interlocutors use discrepant same-turn self-repair operations to achieve single or multiple communicative goals, such as improving precision, increasing credibility, highlighting their points, skirting questions, and confirming information. Additionally, when the epistemic stance of the trouble source is [K+], speakers employ most same-turn self-repair operations to keep their [K+] epistemic stance by improving precision and increasing credibility of their utterances or use reformatting or inserting to downgrade epistemic stance to [K−] by decreasing the certainty of their utterances. These findings shed light on the understanding of same-turn self-repairs in the institutional interaction, particularly in Chinese civil courtroom interaction.
Common mental disorders in Gestalt therapy treatment: a multiple case study comparing patients with moderate and low integrated personality structures
Authors: Kaisler Raphaela E. , Fede Manfred , Diltsch Ulla , Probst Thomas , Schaffler Yvonne
Published: December 2023

Introduction

Empowerment is central to self-development and growth in Gestalt therapy. The self evolves through interactions with others, forming self- and object-relations, and ego-functions. Underlying structural functions build the ability to regulate, differentiate, and integrate experiences, leading to self-, and emotion-regulation. Our study examined the self-development of seven clients with prevalent mental health issues and structural challenges, all of whom underwent 30 sessions of Gestalt therapy in a real-world individual therapy context.

Methods

Using a multiple case study approach, we contrasted two client groups: those with moderately integrated and those with low-integrated personality structures, as defined by the operationalised psychodynamic diagnostic manual. Our exploration centered on specific factors of empowerment, therapy processes, and interventions. The study's mixed-method design encompassed quantitative outcome measures (empowerment, wellbeing, psychosocial health, and severity of personality functioning), therapy diaries from both clients and therapists, and semi-structured client interviews about empowering factors in therapy.

Results

Both groups showed positive therapy outcomes on wellbeing, psychosocial health, and empowerment. Specific empowerment-related factors included promoting experiences, relationships, and self-efficacy in the low-integrated group. Support of self-regulation was reported to be essential for successful outcomes in the moderately integrated group. While the therapy processes proceeded similarly in both groups, we observed a strong focus on body awareness-oriented interventions and promotion of verbalisation in the low-integrated group and a relationship-oriented emphasis in the moderately integrated group. Emotional experience linked to positive experience was limited in the low-integrated group, suggesting an impairment of emotional processing, including bodily felt feelings. No change was reported in the level of personality functioning after 30 sessions in both groups.

Discussion

These results underscore the need for tailored therapeutic approaches based on the client's level of personality integration. Future research should probe the long-term effects of therapy and delve deeper into shifts in personality functioning, especially concerning emotional and bodily experiences. In practical terms, therapists should prioritize linking bodily sensations with emotions for clients with low-integrated personalities. For those with moderate integration, the emphasis should be on fostering exploration, awareness, and bolstering self-regulation.
Dealing with food safety concerns among urban poor when eating out: social practices in Dhaka, Bangladesh
Authors: Haque Md. Latiful , Oosterveer Peter , Vignola Raffaele , Rasheed Sabrina
Published: December 2023

The article explores eating-out practices among poor urban consumers in Bangladesh and their strategies to cope with food safety concerns. Using social practice theory, we implemented interviews and a household survey to analyse the eating-out practices of adult slum dwellers in Dhaka, Bangladesh and their food safety coping strategies. We identified two different dominant eating out practices: ‘snacking’ and ‘having a complete meal’. By reviewing the food safety concerns and coping strategies, we found that despite varying concerns, coping strategies are broadly similar across these two practices. The concerns include food presentation, unhygienic conditions, and unknown processing, while searching for information, using heuristic tools, and avoidance are the main coping strategies. These strategies are applied in both practices and do not exhibit significant differences in socioeconomic considerations and safety concerns. This indicates that the urban poor lack the resource and competencies to manage their concerns. The conclusion section presents a conceptual framework for future research on food safety coping strategies in urban eating-out practices. We also underline the need for context-specific policy interventions to ensure food safety in the urban food system of the global south.
Decapod Crustacean Records from A Collection of Marine Soft-Bottom Macrofauna of the Italian Waters Supporting the Update of Checklists and Registers of the Mediterranean Basin
Authors: Bacci Tiziano , Targusi Monica , Lattanzi Loretta , Marusso Veronica , Trabucco Benedetta , Tomassetti Paolo
Published: December 2023

Decapod crustaceans are important components of the fauna of soft-bottom habitats. In this work, the records of decapod crustaceans are provided through the analysis of a large soft-bottom benthic macroinvertebrates dataset of the Central Mediterranean Sea. Decapod crustacean assemblages were collected in the last twenty years by a Van Veen grab in 42 study sites located along the Italian coasts at depths ranging from 1 up to 120 m. The spatial distribution of the crustaceans examined, which include 120 species belonging to 40 families, was investigated according to the biogeographical zones identified in the Italian seas. The spatial distribution of 36 species was updated, comparing the ISPRA decapod crustacean dataset with the most recent Italian checklists. For the species updated, the number of specimens, the year and season of sampling, and environmental data, such as the bathymetric range and habitat details, are provided for each site investigated. Data are discussed and compared with the existing literature, also referring to what is reported in the World Register of Marine Species (WoRMS), with the aim of contributing to the knowledge of the biodiversity of the marine species and supporting the updating of checklists and registers in the Mediterranean Basin.
Expectation and Optimal Allocations in Existential Contests of Finite, Heavy-Tail-Distributed Outcomes
Authors: Vince Ralph
Published: December 2023

Financial time series and other human-driven, non-natural processes are known to exhibit fat-tailed outcome distributions. That is, such processes demonstrate a greater tendency for extreme outcomes than the normal distribution or other natural distributional processes would predict. We examine the mathematical expectation, or simply “expectation”, traditionally the probability-weighted outcome, regarded since the seventeenth century as the mathematical definition of “expectation”. However, when considering the “expectation” of an individual confronted with a finite sequence of outcomes, particularly existential outcomes (e.g., a trader with a limited time to perform or lose his position in a trading operation), we find this individual “expects” the median terminal outcome over those finite trials, with the classical seventeenth-century definition being the asymptotic limit as trials increase. Since such finite-sequence “expectations” often differ in values from the classic one, so do the optimal allocations (e.g., growth-optimal). We examine these for fat-tailed distributions. The focus is on implementation, and the techniques described can be applied to all distributional forms. We make no assertion that the empirical data for any financial time series comports to the generalized hyperbolic distribution (GHD), which we will use as a proxy of any heavy-tailed distribution herein. Rather, we have selected the GHD to highlight the process for determining expectation and other important time-dependent metrics in existential contests, using the GHD as a generic proxy for the specific distributional form an implementor of the presented technique might ascribe to the empirical data.
“Open Sobornicity” in Dumitru Stăniloae’s Theology—Christian Orthodox Creeds in the Context of Contemporary Ecumenical Relationships
Authors: Neacșu Nathanael
Published: December 2023

This study analyses several of the key principles of Father Dumitru Stăniloae’s conception of Orthodox ecumenical theology. It considers the foundations, the possibilities, and the type of ecumenical manifestation, specifically regarding the relationships between Orthodox Christians and Christians of different denominations and traditions. This is a necessity as the result of the profound actual theological crisis and the lack of clarity of principles of faith at the ecumenical level across the whole Christian world. This study fills this gap by seeking to identify the doctrinal principles that define Orthodox Christian life in an ecumenical context and the manner in which such theology can be practically applied.
CONTEMPORARY RESEARCH STRATEGIES IN PEDAGOGICAL STUDIES: EXPERIENCE OF UKRAINE AND POLAND
Authors: Nychkalo N. , Vovk M. , Yanytska-Panek T.
Published: December 2023

Throughout the late 20th to the first quarter of the 21st century, three strategies of pedagogical research have been developed in the field of educational and pedagogical sciences. These strategies have evolved in response to the issues addressed in dissertation research and involve the conduct of scientific inquiries through the researcher's activities. The strategies include experimental, comparative-pedagogical, and historical-pedagogical approaches. Currently, within the European context, stable methodological strategies for conducting research studies in the field of educational and pedagogical sciences have emerged. These strategies predominantly focus on experimental research utilizing quantitative characteristics to analyze the dynamics of the growth of a specific quality among the researched category of individuals. They also involve comparative pedagogical research aimed at presenting best educational practices from international experiences and implementing them in the education systems of other countries. Furthermore, there is an emphasis on the revitalization of historical-pedagogical experiences of a particular country to preserve national identity, affirm cultural values, and promote education and scientific values at the state level. The methodology of pedagogical research requires further substantiation and continuous updating of the conceptual-terminological apparatus, which cannot be considered narrowly and should develop within the confines of a single subject area. Interdisciplinarity in scientific inquiry becomes an objective necessity. Psychopedagogy and digital pedagogy as scientific disciplines in the 21st century acquire special significance and are promising in online research. Ukrainian and Polish researchers have significant experience in crystallizing contemporary methodological strategies in pedagogical research. Joint scientific discussions between them contribute to the development of methodological pluralism, openness in research space, and interdisciplinary scientific exploration, taking into account traditions and innovations in the field of educational sciences. This collaboration also plays a role in affirming the development of pedagogical sub-disciplines in the context of open science and the digitization of research content.
WHEN THE MEANS BECOMES THE END. SOME NON-OPPORTUNISTIC THOUGHTS ABOUT THE UNIVERSITY AND UNIVERSITIES
Authors: Duda H.
Published: December 2023

Political and social changes following the collapse of communism in the last quarter of the 20th century and the globalization that progressed in the early 21st century led to the need of rebuilding academic institutions. This has also initiated discussions about the condition of the University. In this article, the author, taking Fr. Jacek Woroniecki's article Pupil or book (first printing 1918) as a starting point, shows that the university is in a state of permanent crisis. Its source is alienation, i.e. a situation in which what is only a means becomes an end through the activities of people and institutions, "art for art's sake." Just as in the days of Fr. Woroniecki's activity writing scientific books became an end in itself, the shortest and surest way to achieve a professorship, so in our modern times the tools of the so-called parameterization of scientific achievements have become alienated. Reading Fr. Woroniecki's article inevitably leads to the conclusion that alienation creates pathologies in social life. However, in each era it manifests itself in a different way.
HRYHORII LEVCHENKO’S ARTISTIC AND PEDAGOGICAL ACTIVITY IN THE CONTEXT OF UKRAINIAN MUSIC TEACHER TRAINING DURING THE LAST QUARTER OF THE 20th – BEGINNING OF THE 21st CENTURY
Authors: Sulaieva N.
Published: December 2023

The article highlights the analysis results of the artistic and pedagogical activity of the outstanding Ukrainian teacher, musician, folklorist, professor, Head of the Music Department, and leader of the Ukrainian folk choir “Kalyna” of Poltava V. G. Korolenko National Pedagogical University Hryhorii Levchenko.

The analysis has been carried out in the context of future music teacher training in Ukraine during the last quarter of the 20th - the beginning of the 21st century. It is emphasized that with his professional activity, H. Levchenko strengthened the process of providing education to students majoring in spatiality Secondary Education (Music Art) at the institution of higher pedagogical education.

Attention is focused on the fact that during the last quarter of the 20th century, the teacher created a classical university department of music with a skilled staff. It is emphasized that during total Russification in the 80s and 90s, teachers led by H. Levchenko managed to adhere to the position of training music teachers based on the best examples of Ukrainian musical heritage. It is indicated that at the end of the 80s of the 20th century, H. Levchenko founded the Ukrainian folk choir “Kalyna.” It became one of the leading student collectives of Ukraine during the last decade of the 20th and the beginning of the 21stcentury. It popularized the folk art of its native land on the territory of Europe. It is established that an essential component of student education during the specified historical period was the combination of formal artistic education with non-formal artistic education not only in the “Kalyna” choir but also in other artistic and creative groups. At the beginning of the 21st century, these groups became creative laboratories of the department. Even today, students undergo musical and performing practice in conducting and choral, vocal and performing, and choirmaster training there. It significantly strengthens their professional competence. It is emphasized that the most valuable thing in Professor H. Levchenko’s work for more than half a century of artistic and pedagogical activity is his ascetic work on the formation of a music teacher as a patriot of his country, capable of preserving and multiplying the musical heritage of our people and educating the young generation on the best examples of musical art of Ukraine.
PROFESSOR HRYHORII LEVCHENKO’S PERSONALITY PHENOMENON
Authors: Tytarenko V.
Published: December 2023

The article reveals Professor Hryhorii Levchenko’s (1933-2022) personality phenomenon, who was a teacher, choirmaster, composer, researcher of national musical folklore, public figure, founder and artistic director of the Ukrainian folk choir “Kalyna” of the Poltava V. G. Korolenko National Pedagogical University (1979-2022). The author has shared her own memories of the pedagogue-artist, summarized the forty-year experience of her cooperation with H. Levchenko, and convincingly proved the unique integrity of his bright personality. The phenomenon of the artist’s personality is based on three defining values: Ukrainian folk song, mother tongue, and Ukraine. It is also characterized by his unique personal qualities. It is emphasized that the artist saw his mission in the preservation, development, and popularization of the national song culture, which he successfully implemented in his multifaceted activities: organizational, educational, upbringing, methodical, artistic, and scientific. In each of them, the professor vividly demonstrated a creative approach. The result of the implementation of the creative approach is the author’s educational manuals and musical works, arrangements, and processing of Ukrainian folk songs, original pedagogical, artistic, and managerial methods, techniques, and tools, as well as a unique system of educating the future teacher. They are waiting for further understanding, generalization, and theoretical analysis.
AESTHETIC COMPETENCE OF APPLICANTS FOR HIGHER PEDAGOGICAL EDUCATION: STRUCTURAL AND FUNCTIONAL MODEL
Authors: Ruixue Z.
Published: December 2023

The purpose of the article is to consider the pedagogical model of forming the aesthetic competence of future teachers by means of choreographic art, which combines structural analysis and functional modeling.

The pedagogical modeling of aesthetic competence of higher pedagogical education students by means of choreography is considered as structuring the educational process for analyzing and managing it in order to solve current problems with a systematic approach.

The proposed pedagogical model is a tool and conceptual framework that facilitates the understanding and explanation of the processes that occur during the formation of future teachers' aesthetic competence and reflects the effectiveness of the impact on their professional level.

The purpose of the pedagogical model of forming the aesthetic competence of future teachers by means of choreographic art is to prepare the teacher for effective influence on the personal development of students.

The result of the proposed model implementation is the achievement of a high level of development of the dynamic personal capacity of future teachers as carriers and creators of culture.

The model includes the following blocks: goal setting, basic, organizational, implementation, and reflective.

The structure of the pedagogical model reflects the interrelationships between the following elements: the purpose and result of the educational process; methodological approaches; pedagogical principles; stages, forms, methods, and techniques of teaching. The reflexive block of the model includes structural components, criteria for assessing levels of development, and diagnostic tools for analyzing the results of the formation of aesthetic competence of future teachers by means of choreographic art.

The presented structural-functional model reflects the organization of aesthetic training of future teachers as a system in which the systemic factor is the interconnection and interdependence between the goal and the result of the pedagogical process.
THE CONTRIBUTION OF MIGRANT ARTISTS-EDUCATORS TO THE DEVELOPMENT OF ART LITERACY IN THE FIRST HALF OF THE 20TH CENTURY
Authors: Bolshanina O.
Published: December 2023

The article analyses the theoretical and methodological ideas of artists-pedagogues who emigrated abroad in the first half of the twentieth century. The works of such teachers as O. Arkhypenko, V. Hagenmeister, E. Kozak, S. Kolos, V. Lasovsky, K. Malevych, M. Samokysh, and V. Sichynskyi are analyzed. The fundamental ideas of the artists, which were highlighted in their theoretical works, are outlined. Several opinions are formulated regarding the purposes of writing these works and their role in developing art education within the studied period. The article summarises and generalizes the results of the analysis of the scientific and pedagogical potential of the works of migrant artists of the first half of the twentieth century and notes several distinctive aspects. The first aspect is that, broadly, the article was divided into theoretical works of historical and art historical content and methodological works. The second defined aspect is the works of artists and pedagogues who found themselves in exile and played an essential role in enriching and shaping the public opinion of other countries, which were influenced by Ukrainian artistic and peda-gogical ideas.

The author analyses the reflection of the level of Ukrainian art education in the first half of the twentieth century and describes its original nature, which Ukrainian emigrants proposed to various art educational institutions worldwide.

An opinion is formed on the work of Ukrainian artists-teachers (who were in emigration) in various vocational and higher art education institutions, who have created their Ukrainian community outside Ukraine, in different parts of the world, preserving the authenticity of teaching fine arts not only to Ukrainian students abroad but also to representatives of other countries of Europe and America.

The article provides recommendations on various areas of studying fine arts in higher and vocational education institutions and their use in modern theory and practice.
Signifier and Signified Meaning In "The Spongebob Squarepants Movie": A Study of Semiotics
Authors: Fauzan Muhammad , Suswanto Deni , Sakinah R. Myrna Nur
Published: December 2023

Abstract

In this study, the researcher analyzes the semiotics study of a movie entitled The SpongeBob SquarePants Movie, in which the movie has markers that can be used for this method. The research method chosen by the author is qualitative. The data analysis that has been chosen by the author is The SpongeBob SquarePants Movie; used as the object of analysis. To analyze the study of semiotics, the researcher decided to choose the theory of Ferdinand de Saussure, the theory of semiotics related to signifier- signified. With Ferdinand de Saussure's theory, the researcher finds scenes that contain the Semiotics of the signifier-signified in them. In the movie, the researcher can analyze Ferdinand de Saussure's theory of Semiotics visually. In addition, the researcher can find the Ferdinand de Saussure’s semiotics only 7 scenes.
Tradurre o non tradurre le parole straniere
Authors: Trifone Maurizio
Published: December 2023

In the early twentieth century, Gabriele D’Annunzio successfully proposed tramezzino instead of the English sandwich. Equally successful are some proposals formulated by Bruno Migliorini in the 1930s: autista and regista for the French chauffeur and régisseur. However, the original coinages of Arrigo Castellani in 1987 fail to take root: fubbia for smog, guardabimbi for babysitter, intredima for weekend, velopattino for windsurf, and vendistica for marketing. At the beginning of the 2000s, the volume by Giovanardi, Gualdo, and Coco Italian – English 1-1 reopened the debate among scholars. In 2015 the petition “Dillo in italiano”, launched by Annamaria Testa, achieved enormous success and demonstrated the intolerance of a large part of public opinion towards the massive influx of anglicisms. Following the petition, the Accademia della Crusca established the Incipit Group, a group of experts responsible for monitoring the entry of new anglicisms and suggesting possible Italian alternatives. In 2017, the Nuovo Devoto-Oli dictionary included in its lemmary the section Per dirlo in italiano, containing over 200 cards, that trace a brief history of as many English words or phrases that have penetrated Italian, explaining their meaning and context of use and suggesting a possible Italian equivalent. Il Nuovo Devoto-Oli broadly welcomes the most common anglicisms, helping those who do not know their precise meaning; but at the same time it has no reluctance to propose an Italian alternative, in the profound belief that such an approach is helpful to the reader and makes a positive contribution to the Italian language itself.
On Rayleigh-Ritz and Collocation Methods for Solving Second Order Boundary Value Problems of Ordinary Differential Equations
Authors: Jimoh A. K.
Published: December 2023

In this article, the Rayleigh-Ritz method is compared with the collocation method in solving second order boundary value problems of ordinary differential equations with the associated boundary conditions. The trial solution for the Rayleigh-Ritz method has to be chosen in such a way that the linearly independent functions must satisfy the boundary conditions. The collocation method, on the other hand make use of any basis function as the trial solution. The trial solution is then made to satisfy the differential equation and the boundary conditions at some interior points in the solution interval. Results obtained using the two methods show that the collocation method is simpler, easier and more accurate than the Rayleigh-Ritz method.
User Experience Analysis on Bakamla Messenger Applications Using User Experiences Questionnaire (UEQ)
Authors: Hozairi  , Buhari  , Rofiudin  , Syariful Alim
Published: December 2023

User experience describes the experience a user gets when using a software product. This research aims to measure the user experience when using the Bakamla Messenger application. Measurements were carried out using the User Experience Questionnaire (UEQ) method. The research was carried out by distributing online questionnaires to users of the Bakamla Messenger application, with a total of 117 respondents. The measurement results for the attractiveness aspect of 2.26, clarity of 2.30, efficiency of 2.24, accuracy of 2.27, and stimulation of 2.28 have a positive impression value and are included in the excellent criteria. However, the novelty aspect gets a value of 0.02, meaning it has a negative impression value and is included in the bad criteria, so the innovation of the product needs to be increased. Thus, we recommend that Bakamla messenger application developers focus on improving aspects of the novelty value of the application, such as the level of security of confidential data and the messenger system being able to provide new features beyond messenger in general.
Agile Method in Developing Electronic Local Government Food Reserve Distribution Services (E-CPPD) in Sukabumi City
Authors: Sunarto Asril Adi , Euis Kania Kurniawati
Published: December 2023

Indonesia is a country with a region that has disasters here. As a Regional Apparatus Organization which must distribute regional government food reserves to the community when natural disasters strike, Dinas Ketahanan Pangan, Peternakan dan Perikanan Kota Sukabumi took the initiative to develop an application that can speed up the distribution of aid to the community. This national food reserve policy can support national defense in emergency conditions. The hope is that the development of this application can speed up the administration of official correspondence, where the administration of this correspondence is an element that slows down actions in almost every department, resulting in the length of time that citizens receive assistance. There are many discussions and interviews with various users who need to adapt an environment that requires flexibility in changes to system development, so this system development uses the spiral method. As a result, based on the user requirement list, 100% of user needs can be completed on time. The result, almost nine (9) tons of rice have been distributed to residents spread across 22 of the 33 sub-districts in Sukabumi City.
Comparative SVM and Decision Tree Algorithm in Identifying the Eligibility of KIP Scholarship Awardee
Authors: Asriyanik  , Pambudi Agung
Published: December 2023

Scholarship selection process has specific rules, but if the number of applicants exceeds the quota, a selection process is needed. Based on the observation of a university in Sukabumi, the selection for KIP scholarship has not yet had a standard method. Several methods can be used to assist the selection process, such as classification based on historical data of applicants. The algorithms used for classification include Decision Tree (DT) and Support Vector Machine (SVM). The research process uses SEMMA (Sample, Explore, Modify, Model, Assess) method. Dataset for KIP scholarship awardee from 2021-2022 consist of 519 samples with 16 attributes. From the exploration results, the most important features for model modeling are Status DTKS, Status P3KE, Father's income, mother's income, combined income, and performance. These attributes are converted into numerical data to facilitate model fitting. The K-Fold Cross-Validation results for the Decision Tree model in the case of KIP Scholarship classification yield an accuracy of 78.44% for the entire test dataset, a precision of 0.73107, indicating that 73.11% of the predictions are true, a recall (sensitivity) of 78.45%, and an F1 score of 73.20%. The results for the SVM model are an accuracy of 80.17%, a precision of 84.44%, and a recall of 80.17%.
Application of Agile Development Methods in the Development of Integrated Systems for Vehicle Body Repair
Authors: Indrayana Didik , Prajoko  , Sunarto Asril Adi
Published: December 2023

PT XYZ Auto Body Repair is a company that focuses on repairing and servicing vehicles, especially cars that have been involved in accidents or disasters. Currently, data processing still uses physical forms, which has proven to be inefficient because it takes significant time, labor, and resources. Collecting and inputting data from various forms requires a large effort, while systems that are not integrated cause delays in providing the required information. These challenges impact the company's ability to make decisions quickly and on time, especially in the face of increasingly tight and complex business competition. Therefore, an efficient and integrated solution is needed. Seeing this problem, it was decided to develop an integrated vehicle repair system by applying agile development methods, especially the Extreme Programming model. This approach allows development in an iterative, fast, adaptive manner, and actively involves users at every stage of development. Experience has shown that applying the Extreme Programming model can produce an integrated system that meets user needs in a short time. With this system, companies can produce reports quickly without reduplication or repetitive data processing. All parts involved in the vehicle repair process will be connected to one company server, creating the efficiency and accuracy needed to support business growth in a dynamic business environment.
Breast Cancer Screening Application Based on Android with the Certainty Factor Method
Authors: Suprapto  , Anita Kenty Wantri
Published: December 2023

According to Globocan records, in Indonesia in 2020 there were 396.314 new cancer cases. And 234.511 people were declared dead. Women are a group with a high risk of developing cancer. If cancer is detected at an early stage, this can increase the chance of cure to 80-90%. Early detection of cancer can be done using several methods, for example, for breast cancer, the method of checking can be using the SADANIS (Clinical Breast Examination) and SADARI (Self Breast Examination) methods. In this research, a mobile application will be developed that can be used as a guide in carrying out early cancer detection independently. The early detection system uses an Android-based expert system and certainty factor method. The case study in this research is on breast cancer. Based on the results of accuracy testing with expert diagnosis as a reference, an accuracy value of 90% was obtained. The inaccuracy of this expert system is 10% which can be caused by several possibilities, namely the expert's subjectivity in providing confidence values for disease symptoms or the small number of symptoms entered.