bluuebunny/crossref_metadata_2025 huggingface dataset:
УПРОВАДЖЕННЯ ДУАЛЬНОЇ СИСТЕМИ НАВЧАННЯ У ЗАКЛАДАХ ВИЩОЇ ОСВІТИ В ПРОЦЕСІ ПІДГОТОВКИ МАЙБУТНІХ ФАХІВЦІВ ВОДНОГО ТРАНСПОРТУ
Authors: Скляренко Інна
Published: November 2019

У статті викладено положення щодо впровадження дуальної системи навчання у вищих навчальних закладах при підготовці майбутніх фахівців водного транспорту. Розглянуто основні питання і проблеми, пов’язані з організацією впровадження у закладах вищої освіти дуальної системи навчання. Обґрунтовано необхідність упровадження даної системи навчання у Державний університет інфраструктури та технологій із урахуванням її переваг. Науково підтверджено й доведено, що організація навчального процесу за дуальною формою зумовлена необхідністю індивідуалізації навчання, посилює практичну спрямованість підготовки шляхом інтеграції в освітній процес великого обсягу виробничої практики, створює якісно нові умови для організації практичної підготовки, підвищує професійну мобільність студентів, що, безсумнівно, підвищує конкурентоспроможність випускників і забезпечує їх працевлаштування в морському флоті. Дуальна система орієнтована на безпосередню підготовку фахівців водного транспорту до практичної професійної діяльності, передбачає пряму участь у цьому процесі морських суден і від традиційної існуючої системи навчання відрізняється спрямованістю і ступенем наближеності змісту підготовки фахівців до реальних умов морського флоту.
WORK-BASED LEARNING INVOLVING THE DUAL EDUCATION ELEMENTS
Authors: Кулалаєва Наталя , Леу Сніжана
Published: November 2019

The article analyses the dual education capacity for implementing work-based learning (WBL) for future skilled workers in order to improve the quality and enhance their professional training practice orientation. It is emphasised on information accumulating in the national scientific-pedagogical dimension on dual education elements introducing into future skilled workers professional training. Therefore, the appropriate issues on relevance, expediency, perspective and necessity are actively studied. It is noted that dual education applying is to create real production situations, assure cooperation of students and experienced mentors from enterprises, and demonstrate students’ autonomy and initiative in the workplace. It also represents the students’ involvement into professional culture and their professional identity, recruitment possibility for the youth of appropriate qualification, strengthening the practical component of professional (vocational) education (P(V)E) system, etc. It provides characteristics for WBL activities and its main forms: work experience, traineeship, work-shadowing, mentoring, apprenticeship, cooperative learning, partnership-based learning, internship or work placement.
Re-visioning creativity in couple psychoanalysis: the importance of Winnicott and Bollas in clinical practice
Authors: Hewison David
Published: November 2019

This article suggests that the work of Donald Winnicott and Christopher Bollas is essential in helping us re-vision the current dominant Kleinian and post-Kleinian model of contemporary couple psychoanalysis. It shows how their different understanding of the nature of creativity draws upon different conceptions of the creative couple and upon a radically different understanding of the relationship between the self and the unconscious. It suggests that their thinking on creativity and the unconscious is useful in our work with couples. It goes on to focus on the clinical and technical implications of these ideas in five areas: gesture; repetition; compliance; mood and emotional atmosphere; and the use of objects.
Should “sensate focus” have a place in couple psychoanalytic psychotherapy?
Authors: Pacey Susan
Published: November 2019

In the UK, psychotherapeutic treatments for sexual problems are split between couple psychoanalytic or psychodynamic psychotherapy, which focuses on the mind, and psychosexual or sex therapy, which focuses on the body, principally using the intervention “sensate focus” (Masters & Johnson, 1970). Remarkably, there are few published papers on the integration of these two approaches, indicating a near-absence of debate and perpetuating the professional bifurcation. More contributions on this topic are needed. This article provides an overview of the field (psychoanalysis and sex therapy) and presents excerpts from the author’s recent doctoral study (Pacey, 2018), using Winnicottian theories to link the two paradigms and support the integration of sensate focus into psychoanalytic couple therapy.
“Sexual compulsivity”, “sexual addictions”, or “hypersexuality”? An overview of contrasting perspectives
Authors: Markovic Desa
Published: November 2019

Many labels have been used and are currently in use referring to “sexual compulsivity”, “sexual addictions”, and “hypersexuality”, depending on the theoretical and ethical positioning. This issue has been a subject of much controversy and debate within sexology, psychosexual therapy, psychiatry, and psychotherapy, triggering strong reactions and opposing viewpoints. This article discusses the historically significant as well as currently prevailing views on the origins, diagnostic criteria, symptomatology, and proposed forms of treatment of this phenomenon. Points of connections as well as contrast will be highlighted amongst different perspectives, and implications will be drawn for psychotherapy assessment and treatment.
Addiction and addiction recovery: a qualitative research viewpoint
Authors: Kemp Ryan
Published: November 2019

Addiction and recovery from addiction are described by synthesising fifty-two qualitative studies from thirty-two years of research. Based on the lived experience of individuals this approach creates an understanding which emphasises not just the active phase of addiction, but the period before this phase. In addition the interpersonal, temporal, and community aspects of this condition are emphasised. A prominent feature is that addiction destructs the individual’s sense of self. In recovery this damaged self has to be reconstructed while healing of body and relationships are prominent. The individual should also find a way back into communal existence, thus restoring a sense of meaning into their lives.
Group relations love: sentience and group relations work - Part II
Authors: Short Ellen L.
Published: November 2019

Part II of this article will provide a focus on sentience and group relations work through the narratives of individuals who responded to a questionnaire about their lived experiences of group relations conference work. Formulated meanings, themes, and theme clusters of the respondents’ narratives will be presented and explored using application of phenomenological analyses. Group relations love and the possibility of love of, and for, group work will be more deeply explored. A discussion and implications for group relations work will also be presented.
Working with attention and distraction in leadership development
Authors: Simpson Peter , French Robert , Sheffield Rob
Published: November 2019

Bion’s theory of groups is used to explore the dynamics of learning on a leadership development programme. The dynamic of a group is influenced by the capacity of its members to negotiate, consciously and unconsciously, the tension between the opposed tendencies of attention and distraction, which is related to the tension between a desire to learn and a hatred of the process of development. Bion’s model of work-group and basic-assumption mentalities, which we equate with the dynamics of attention and distraction, is used to reflect on a two-month period of a development programme in a UK public service organisation. In related literature there is a tendency to focus on the pathology of basic-assumption mentality with limited interest in the healthy functioning of workgroup mentality. Basic-assumption mentality contributes to understanding a group that is distracted from its purpose, but a focus on this, without comparable attention to work-group mentality, can lead to an inappropriately negative
view of group process. This is contrary to Bion’s essential optimism about the powerful psychological structure of work-group mentality. The article demonstrates the importance of combining an analysis of both attention and distraction to fully appreciate the complex dynamic of groups engaged in a developmental process.
Antalyalı Athenaeus’un Felsefesinde Ruh (Pneuma) ve Beden İlişkisi
Authors: DURMAZ Nihat
Published: November 2019

Antik Yunan’da ortaya çıkan felsefe, MÖ 4. yüzyıldan MÖ 1. yüzyıla kadarki süreçte pek çok değişime uğrayarak gelişimini devam ettirmiştir. Felsefe, doğadan insana geçerek ilk değişimini, Platon ve Aristoteles tarafından felsefenin genel çerçevesinin çizildiği sistematik dönemle de ikinci değişimini gerçekleştirmiştir. Bu süreçte çizilen genel çerçevenin felsefenin yanında tıp alanını da etkilediği ve bu etkinin MÖ 1. yüzyılda açıkça ortaya çıktığı görülür. Bu çalışma, söz konusu dönemde filozof olduğu kadar hekim unvanıyla da tanınan Athenaeus’un ruh/beden düalizminde hangi düşünce okullarını benimsediğini ve ne tür kaynaklardan beslenerek mesleğini icra ettiğini ortaya koymayı amaçlamaktadır. Buna göre Athenaeus’un felsefesini Platon ve Stoacı görüşlerden hareketle açıklamanın o dönemin önemli bir tartışma zeminini oluşturan ruh/beden ilişkisini daha anlaşılır kılacağı ifade edilebilir. Nitekim Roma İmparatorluğu’nun kuruluş döneminde hekimler, fizyolojik ve zihinsel olduğu farz edilen pek çok hastalığı psikolojik tedavilerle gidermeye çalışmışlardır. Ayrıca bu anlayış, bedensel hastalıkların ruhsal durumlarla ilişkili olduğunu göstermesi açısından önemlidir. Hekimlerin psikolojik rahatsızlığı bulunan hastaları dikkat dağıtıcı egzersizlerle iyileştirme çabaları, böyle bir düşüncenin sonucu olarak okunabilir.
Maternal Socioeconomic Factors Affecting Birth Weight of New Born Babies Born in Combined Military Hospital Dhaka
Authors: Md Asaduzzman - , Rahman Md Saydur
Published: November 2019

Background: Low birth weight is one of the deleterious outcomes of pregnancy. To identify the factors contributing to LBW is therefore of paramount importance. But a very little attention had been paid to address the riddle. This effort is to candle the light on maternal socioeconomic factors on birth weight.

Objective: To delineate the pattern of birth weight of newborn babies delivered in CMH Dhaka and ascertains selected demographic, socio-economic characteristics of the mothers.

Methods & Materials: This cross-sectional study was conducted in Combined Military Hospital Dhaka from September to December 2011 on 110 respondents. Data were collected by interview using semi- structured questionnaire. Data were checked, edited, coded, categorized, cleaned and analyzed using software (SPSS version 16)

Results: All the mothers were educated. Mothers who passed SSC exam, 35.5% were highest. Lowest education level was primary, 10%. SSC and below educated mother gave birth to 16.75 LBW babies. The average birth weight babies, 94.74% were delivered by HSC and higher educated mothers. All LBW babies were born other than officer's family. The mean monthly income was Tk 16533. 33% LBW babies born who had family income _< Tk. 10,000, 52.3% higher birth weight babies had family income  _> Tk. 20000 but results was not statistically significant (p>.05).

Conclusion: All these findings suggest that a substantial evidence of socioeconomic factors like family income, maternal education and social status has an effect on birth weight. Utilizing health care facilities, better training, educating mother, addressing demographic factors, condition can be improved.

Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 138-142
Review on Chromobacterium violaceum, a Rare but Fatal Bacteria Needs Special Clinical Attention
Authors: Sharmin Sadia , Kamal SM Mostofa
Published: November 2019

Chromobacterium violaceum is isolated from soil and water in tropical and subtropical areas. This Gram negative, capsulated, motile bacillus is considered as a saprophyte but occasionally it can act as an opportunistic pathogen for animals and human. It causes skin lesion with liver and lung abscesses, pneumonia, gastrointestinal tract infections, urinary tract infections, osteomyelitis, meningitis, peritonitis,  endocarditis, respiratory distress syndrome and septic shock. Increasing reported cases with Chrombacterium violaceum infection has been noticed in recent decades. It should be considered for its difficult-to-treat entity characterized by a high frequency of sepsis, distantant metastasis, multidrug resistance and relapse. High mortality rate associated with this infection necessitate prompt diagnosis and  appropriate antimicrobial therapy

Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 169-175
From the Desk of Editor in Chief Vol.10(2)
Authors: Rahman Md Tahminur
Published: November 2019

Abstract not available

Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 186-187
From Ancestor Worship to Monotheism. Politics of Religion in Lombok
Authors: CEDERROTH SVEN
Published: November 2019

No abstract available
Is There a Theology of Rabbinic Judaism?
Authors: NEUSNER JACOB
Published: November 2019

No abstract available
Influence of an energy factor on the relations between Azerbaijan and Russia
Authors: Temnikov Roman
Published: November 2019

The relations between Azerbaijan and Russia have deep historical roots. For
about two centuries they have been part of common state – Russian empire and
the Soviet Union. Such cohabitation in the frames of one state had led to
emergence of common features in development of two societies. One of these
features is an important role of oil and gas production in economy.
But despite of this similarity the Azerbaijani-Russian relations were not always
benevolent. First of all, Azerbaijan for almost two centuries had been under
Russian occupation. Even after dissolution of the USSR the relations of the
former center – Moscow with the former Soviet republic which restored the
independence – Azerbaijan, remained difficult. Practically from the first years
of independence energy factor in the Azerbaijani-Russian relations has had the
negative impact on already tense relations between two countries.
During the modern period, after the beginning of gas production on new fields
in Azerbaijan and after completion of the Southern gas corridor’ construction
on delivery of the Azerbaijani gas to Europe, the Azerbaijani-Russian relations
will expect hard times again.
RUSSIA: FROM COLD WAR VIA “PEACE DIVIDEND” TO HYBRID WAR IN EUROPE. HOW TO RECONCILE EUROPE'S STRATEGIC INTERESTS WITH RUSSIA'S LEGITIMATE INTERESTS
Authors: IONIŢĂ Crăişor
Published: November 2019

Abstract:
As of today, Europe has to face new asymmetric threats, including Hybrid Warfare, terrorist attacks, and illegal migration that transcend the common security aspects and have further roots beyond its borders, in unsolved hot spot areas, like Eastern and Southern neighbourhood. For many military theorists, the Ukrainian Crisis represented a huge opportunity to restart debates regarding hybridity in future warfare. Some definitions and conceptual elements regarding hybrid threats and hybrid challenges have been developed since the Second Lebanon War of 2006 and were improved after the 2008 Chechen War. Hybrid Warfare theory has been developed by Russia since 2004, as the future conflict concept to counter NATO’s expansion to the East and the installation of the US Anti-Missile Shield in Europe. meanwhile, Western Governments has defined the hybrid threat as an issue rather than as an operating concept that requires a solution. as a result, up to now no American National Strategy or doctrine has incorporated this theory as a new form of future conflicts. In conjunction with reviewing and adjusting strategies and war fighting concepts, the defence community must re-evaluate the force structure needed for future conflicts and build adequate capabilities. With a wider range of threats that may require the need to employ various capabilities simultaneously, NATO and member states must continue their efforts to strive for greater joint operations and possibly inter-dependence. With EU support, they must transform their industrial-era organizational structures into more agile, information-, and knowledge-based enterprises, which requires a large investment in ideas, technology, and people.
Deweloper i nabywca lokalu mieszkalnego lub domu jednorodzinnego jako strony umowy deweloperskiej
Authors: Leśniewski Damian Dominik
Published: November 2019

Autor w swoim artykule omówi
kwestię stron umowy deweloperskiej. Postara
się przedstawić podstawę prawną dotyczącą
przedmiotu wykładu. Omówi także prawa i
obowiązki strony umowy deweloperskiej,
wynikające zarówno z tzw. ustawy deweloperskiej, a także z innych aktów prawnych. Twórca
przedstawi uprzywilejowaną pozycję nabywcy
w stosunku do dewelopera w kontekście
ochrony praw strony kontraktu, a także poruszy
problematyczną kwestię w przypadku, gdy
zarówno deweloperem, jak i nabywcą jest
przedsiębiorca. W artykule za punkt wyjścia
przyjęto przepisy Kodeksu cywilnego, ustawy z
dnia 16 września 2011 r. o ochronie praw
nabywcy lokalu mieszkalnego lub domu jednorodzinnego (Dz. U. 2011 nr 232 poz. 1377 ze
zm.), ustawy z dnia 16 lutego 2007 r. o ochronie
konkurencji i konsumentów (Dz. U. Nr 50, poz.
331) oraz innych ustaw
Święty Krzyż – początki turystyki pielgrzymkowej (1135 r.)
Authors: Zaborniak Stanisław , Dzióba Marek , Żegleń Patrycja
Published: November 2019

Intentional pilgrimages to
sanctuary at the Holy Cross in Łysa Góra
overtook pilgrimages do other Marian
shrines in Poland. Monastery’s location, its
history and first of all its mystery of the
Holy Cross relics were the main goal of
many pilgrimages, especially Basilica which
is protected by Virgin Mary Oblat’s
Missioners. Amongst relics attracting
pilgrims and tourists to Łysa Góra there are
the following venues:
- post Benedictines’ Abbey, which
includes quadrangle of monastery’s
buildings from XIV and XV centuries with
cloister garth, early-baroque Oleśniccy’s
chapel and late-baroque, classicistic church.
The church originally had a tower that was
destroyed during war activities. There is an
early-baroque wing on the west (Natural
and Sylvan Museum nowadays), and a
baroque bell tower and gate from XVIII
century on the east.
- there is a mummified body in the
crypt of Oleśniccy’s chapel, which was said
that it is a body of Jeremy Wiśniowiecki;
scientific analysis of the corpse from 1980
excepted definitely the thesis. The remains are displayed.
- mummified body unknown
insurrectionist from January 1863
Predesign Considerations for the DC Link Voltage Level of the CENTRELINE Fuselage Fan Drive Unit
Authors: Biser Stefan , Wortmann Guido , Ruppert Swen , Filipenko Mykhaylo , Noe Mathias , Boll Martin
Published: November 2019

Electric propulsion (EP) systems offer considerably more degrees of freedom (DOFs) within the design process of aircraft compared to conventional aircraft engines. This requires large, computationally expensive design space explorations (DSE) with coupled models of the single components to incorporate interdependencies during optimization. The purpose of this paper is to exemplarily study these interdependencies of system key performance parameters (KPIs), e.g., system mass and efficiency, for a varying DC link voltage level of the power transmission system considering the example of the propulsion system of the CENTRELINE project, including an electric motor, a DC/AC inverter, and the DC power transmission cables. Each component is described by a physically derived, analytical model linking specific subdomains, e.g., electromagnetics, structural mechanics and thermal analysis, which are used for a coupled system model. This approach strongly enhances model accuracy and simultaneously keeps the computational effort at a low level. The results of the DSE reveal that the system KPIs improve for higher DC link voltage despite slightly inferior performance of motor and inverter as the mass of the DC power transmission cable has a major share for a an aircraft of the size as in the CENTRELINE project. Modeling of further components and implementation of optimization strategies will be part of future work.
In Vitro Regeneration and ISSR-Based Genetic Fidelity Analysis of Orthosiphon stamineus Benth
Authors: Ali Hanisah , Musa Izzah Farhanah , Abu Bakar Nurul Atikhah , Karsani Saiful Anuar , Yaacob Jamilah Syafawati
Published: November 2019

Orthosiphon stamineus has been widely used as traditional remedy for various illnesses and diseases, such as cardiovascular diseases and epileptic seizures. In this study, direct regeneration through nodal segment of this species was attempted using Kinetin (6-Furfurylaminopurine) and IAA (indole-3-acetic acid). Optimum regeneration media was identified as MS media supplemented with 2.0 mg L−1 Kin plus 0.5 mg L−1 IAA. This yielded the highest number of shoots (5.57 ± 0.42) and leaves (20.53 ± 1.91) per explant. Acclimatization of the resulting in vitro regenerants was successful in all potting mixtures tested. However, potting mixture PF (1:1:1 ratio of black soil/red soil/compost) was identified as the best medium for acclimatization of this species, as it yielded 100% survival percentage after 90 days of acclimatization. Ten in vitro regenerants of O. stamineus were randomly collected after the third subculture and subjected to genetic variation analysis using inter-simple sequence repeat (ISSR) markers. Out of 20 ISSR markers tested, 10 working primers were observed to produce satisfactory amplification of bands, with an average of 7.11 bands per primer. A total of 610 bands were produced by the 10 primers. The percentage of polymorphism was observed to be very low, yielding only 7.32% polymorphism among all samples. Jaccard dissimilarity analysis was also conducted and very low genetic distance (about 0.1) was found among the in vitro regenerants and between the regenerants with the mother plant, thus ascertaining the clonal nature of the plantlets produced in this study.
Long-Term Green Manure Rotations Improve Soil Biochemical Properties, Yield Sustainability and Nutrient Balances in Acidic Paddy Soil under a Rice-Based Cropping System
Authors: Qaswar Muhammad , Huang Jing , Ahmed Waqas , Li Dongchu , Liu Shujun , Ali Sehrish , Liu Kailou , Xu Yongmei , Zhang Lu , Liu Lisheng , Gao Jusheng , Zhang Huimin
Published: November 2019

Cultivation of green manure (GM) crops in intensive cropping systems is important for enhancing crop productivity through soil quality improvement. We investigated yield sustainability, nutrient stocks, nutrient balances and enzyme activities affected by different long-term (1982–2016) green manure rotations in acidic paddy soil in a double-rice cropping system. We selected four treatments from a long-term experiment, including (1) rice-rice-winter fallow as a control treatment (R-R-F), (2) rice-rice-milkvetch (R-R-M), (3) rice-rice-rapeseed (R-R-R), and (4) rice-rice-ryegrass (R-R-G). The results showed that different GM rotations increased grain yield and the sustainable yield index compared with those of the R-R-F treatment. Compared with those of R-R-F, the average grain yield of early rice in R-R-M, R-R-R, and R-R-G increased by 45%, 29%, and 27%, respectively and that of late rice increased by 46%, 28%, and 26%, respectively. Over the years, grain yield increased in all treatments except R-R-F. Green manure also improved the soil chemical properties (SOM and total and available N and P), except soil pH, compared to those of the control treatment. During the 1983–1990 cultivation period, the soil pH of the R-R-M treatment was lower than that of the R-R-F treatment. The addition of green manure did not mitigate the soil acidification caused by the use of inorganic fertilizers. The soil organic matter (SOM), total nitrogen (TN) and total phosphorus (TP) contents and stocks of C, N and P increased over the years. Furthermore, GM significantly increased phosphatase and urease activities and decreased the apparent N and P balances compared with those in the winter fallow treatment. Variance partitioning analysis revealed that soil properties, cropping systems, and climatic factors significantly influenced annual grain yield. Aggregated boosted tree (ABT) analysis quantified the relative influences of the different soil properties on annual grain yield and showed that the relative influences of TN content, SOM, pH, and TP content on annual crop yield were 27.8%, 25.7%, 22.9%, and 20.7%, respectively. In conclusion, GM rotation is beneficial for sustaining high crop yields by improving soil biochemical properties and reducing N and P balances in acidic soil under double- rice cropping systems.
Volatile Fatty Acids in Ruminal Fluid Can Be Used to Predict Methane Yield of Dairy Cows
Authors: Williams S. Richard O. , Hannah Murray. C. , Jacobs Joe L. , Wales William J. , Moate Peter J.
Published: November 2019

The dry matter intake (DMI) of forage-fed cattle can be used to predict their methane emissions. However, many cattle are fed concentrate-rich diets that decrease their methane yield. A range of equations predicting methane yield exist, but most use information that is generally unavailable when animals are fed in groups or grazing. The aim of this research was to develop equations based on proportions of ruminal volatile-fatty-acids to predict methane yield of dairy cows fed forage-dominant as well as concentrate-rich diets. Data were collated from seven experiments with a total of 24 treatments, from 215 cows. Forage in the diets ranged from 440 to 1000 g/kg. Methane was measured either by open-circuit respiration chambers or a sulfur hexafluoride (SF6) technique. In all experiments, ruminal fluid was collected via the mouth approximately four hours after the start of feeding. Seven prediction equations were tested. Methane yield (MY) was equally best predicted by the following equations: MY = 4.08 × (acetate/propionate) + 7.05; MY = 3.28 × (acetate + butyrate)/propionate + 7.6; MY = 316/propionate + 4.4. These equations were validated against independent published data from both dairy and beef cattle consuming a wide range of diets. A concordance of 0.62 suggests these equations may be applicable for predicting methane yield from all cattle and not just dairy cows, with root mean-square error of prediction of 3.0 g CH4/kg dry matter intake.
Bee Collected Pollen and Bee Bread: Bioactive Constituents and Health Benefits
Authors: Mărgăoan Rodica , Stranț Mirela , Varadi Alina , Topal Erkan , Yücel Banu , Cornea-Cipcigan Mihaiela , Campos Maria G. , Vodnar Dan C.
Published: November 2019

Bee products were historically used as a therapheutic approach and in food consumption, while more recent data include important details that could validate them as food supplements due to their bioproperties, which support their future use as medicines. In this review data, data collected from bee pollen (BP) and bee bread (BB) essays will be discussed and detailed for their nutritional and health protective properties as functional foods. Dietary antioxidants intake derived from BP and BB have been associated with the prevention and clinical treatment of multiple diseases. The beneficial effects of BP and BB on health result from the presence of multiple polyphenols which possess anti-inflammatory properties, phytosterols and fatty acids, which play anticancerogenic roles, as well as polysaccharides, which stimulate immunological activity. From the main bioactivity studies with BP and BB, in vitro studies and animal experiments, the stimulation of apoptosis and the inhibition of cell proliferation in multiple cell lines could be one of the major therapeutic adjuvant effects to be explored in reducing tumor growth. Tables summarizing the main data available in this field and information about other bio-effects of BP and BB, which support the conclusions, are provided. Additionally, a discussion about the research gaps will be presented to help further experiments that complete the tree main World Health Organization (WHO) Directives of Efficiency, Safety and Quality Control for these products.
The Important Role of CoQ10 in Aging
Authors: López-Lluch Guillermo
Published: November 2019

Coenzyme Q10 (CoQ10) is an essential lipid present in all cell membranes [...]
Andrographolide, A Natural Antioxidant: An Update
Authors: Mussard Eugenie , Cesaro Annabelle , Lespessailles Eric , Legrain Brigitte , Berteina-Raboin Sabine , Toumi Hechmi
Published: November 2019

Traditionally, Andrographis paniculata has been used as an herbal remedy for lung infection treatments. Its leaves contain a diterpenoid labdane called andrographolide responsible for a wide range of biological activities such as antioxidant, anti-inflammatory, and anti-cancer properties. This manuscript is a brief review of the antioxidant mechanisms and the regulation of the Nrf2 (nuclear factor (erythroid-derived 2)-like 2) signaling pathway by andrographolide.
Study on Preparation of Aluminum Ash Coating Based on Plasma Spray
Authors: Shuaishuai Lv , Jiaqiao Zhang , Hongjun Ni , Xingxing Wang , Yu Zhu , Tao Gu
Published: November 2019

Ultimate aluminum ash (UAA) was used as the key raw material to prepare ultimate spray powder (USP) via water hydrolysis and ball milling, after which the coating was prepared by atmospheric plasma spray. The flowability of the USP was evaluated by the angle of repose; the process parameters of the coating were determined by orthogonal experiment, and the microstructure and properties of the coating were characterized. The results show that the ultimate spray powder after granulation has an angle of repose less than 40°, which meets the requirements of plasma spray. When the spray current is 600 A, the spray voltage is 55 V, the powder flow rate is 22 g/min, and the main air flow is 33 lspm, the prepared ultimate coating has the best comprehensive performance. The microhardness of the coating is 512 HV, which is about 1.5 times the hardness of the substrate; the abrasion rate is 18.53 × 10−3 g/min; the porosity is 0.17% and the average adhesive strength is 8.78 Mpa, which confirms the feasibility of using aluminum ash as a spray powder to prepare a coating.
Influence of Pre-Ionized Plasma on the Dynamics of a Tin Laser-Triggered Discharge-Plasma
Authors: Xu Qiang , Deng Xiaolong , Tian He , Zhao Yongpeng , Wang Qi
Published: November 2019

The effect of laser-current delay on extreme ultraviolet emission by laser-triggered discharge-plasma has been investigated. Typical waveforms for current, voltage, laser signals, and X-ray signals have been compared. Theoretical tin spectra were simulated among the electron temperature ranges from 10 to 50 eV to compare with the experimental results. The results show that longer laser-current delay time is propitious to increase the steady-state time of plasma at high temperatures, and it increases the intensity and spectral purity of 13.5 nm emission in 2% band. The 13.5 nm radiation intensity increases about 120% with the delay increasing from 0.7 to 5 μs, and the extreme ultraviolet (EUV) emission conversion efficiency (CE) increases from 0.5% to 1.1%.
Flexible Framework to Model Industry 4.0 Processes for Virtual Simulators
Authors: Ottogalli Kiara , Rosquete Daniel , Amundarain Aiert , Aguinaga Iker , Borro Diego
Published: November 2019

Virtual reality (VR)- and augmented reality (AR)-based simulations are key technologies in Industry 4.0 which allow for testing and studying of new processes before their deployment. A simulator of industrial processes needs a flexible way in which to model the activities performed by the worker and other elements involved, such as robots and machinery. This work proposes a framework to model industrial processes for VR and AR simulators. The desk method was used to review previous research and extract the most important features of current approaches. Novel features include interaction among human workers and a variety of automation systems, such as collaborative robots, a broader set of tasks (including assembly and disassembly of components), flexibility of modeling industrial processes for different domains and purposes, a clear separation of process definition and simulator, and independence of specific programming languages or technologies. Three industrial scenarios modeled with this framework are presented: an aircraft assembly scenario, a guidance tool for high-voltage cell security, and an application for the training of machine-tool usage.
High-Rise Social Housing in Hot-Humid Climates: Towards an ‘Airhouse’ Standard for Comfort
Authors: Gonzalez-Longo Cristina , Mohd Sahabuddin Mohd Firrdhaus
Published: November 2019

The pressure to provide social housing in a fast and economic way, as well as outdated regulations, constrain the design of these buildings, having serious implications for the comfort of occupants and the environment. This becomes more critical in hot-humid climates, such as Malaysia, with uniformly high temperature and humidity and low wind speeds. In its capital, Kuala Lumpur, an extensive program of construction for high-rise social housing is being carried out, however, shortly after the flats are occupied, or as soon as they can afford it, the residents fit wall mounted air conditioning units. This research started by looking at Malay vernacular architecture and the traditional strategies for ventilation and cooling. After a review of current building regulations and green tools employed in the country, two campaigns of fieldwork were carried out to assess the actual indoor and outdoor thermal and air quality conditions in the buildings, which were found to be inadequate for both the local regulations and international recommendations. The fieldwork also allowed the identification of the critical design issues to address. A ventilation and filtering ceiling system has been identified as one of the possible solutions for the current situation and has been tested through physical and computer models. The system improves comfort by reducing the air temperature, humidity, and amount of airborne particles and gases, as well as constantly providing an adequate airflow rate. It is the first attempt to develop what we have named the ‘airhouse’ standard for tropical countries.
Investigation of the Functional Decline in Proprioceptors for Low Back Pain Using the Sweep Frequency Method
Authors: Nishio Reiya , Ito Yohei , Morita Yoshifumi , Ito Tadashi , Yamazaki Kazunori , Sakai Yoshihito
Published: November 2019

The purpose of this study was to investigate the functional decline in proprioceptors in patients with low back pain (LBP) by evaluating the entire range of response frequencies of proprioceptors. In previous studies, the function of proprioceptors was only evaluated by single frequency vibrations. However, because it is assumed that individual differences exist in response frequencies of proprioceptors, we developed a method using vibration with sweep frequency covering the entire range of response frequencies of proprioceptors. The center of pressure was determined in 35 elderly patients with non-specific LBP (NSLBP) and 28 elderly individuals with non-LBP (NLBP) during upright stances on a balance board without vision. Local vibratory stimulations to lower leg or trunk muscles were continuously varied between 27 and 272 Hz over 60 s to evaluate the proprioceptive predominance of a body location using the relative proprioceptive weighting ratio (RPW). Compared with the NLBP group, the NSLBP group exhibited a lower RPW value for the Vater-Pacini corpuscles. Thus, the NSLBP group relied more on the input of Vater-Pacini corpuscles in the trunk. A reduction in lower leg sensitivity at the Vater-Pacini corpuscles in the NSLBP group was observed.
Cultivation of hMSCs in Human Plasma Prevents the Cytotoxic and Genotoxic Potential of ZnO-NP In Vitro
Authors: Scherzad Agmal , Meyer Till , Ickrath Pascal , Gehrke Thomas Eckhart , Bregenzer Maximillian , Hagen Rudolf , Dembski Sofia , Hackenberg Stephan
Published: November 2019

Zinc oxide nanoparticles (ZnO-NPs) are commonly used for industrial applications. Consequently, there is increasing exposure of humans to them. The in vitro analysis of cytotoxicity and genotoxicity is commonly performed under standard cell culture conditions. Thus, the question arises of how the results of genotoxicity and cytotoxicity experiments would alter if human plasma was used instead of cell culture medium containing of fetal calf serum (FCS). Human mesenchymal stem cells (hMSCs) were cultured in human plasma and exposed to ZnO-NPs. A cultivation in expansion medium made of DMEM consisting 10% FCS (DMEM-EM) served as control. Genotoxic and cytotoxic effects were evaluated with the comet and MTT assay, respectively. hMSC differentiation capacity and ZnO-NP disposition were evaluated by histology and transmission electron microscopy (TEM). The protein concentration and the amount of soluble Zn2+ were measured. The cultivation of hMSCs in plasma leads to an attenuation of genotoxic and cytotoxic effects of ZnO-NPs compared to control. The differentiation capacity of hMSCs was not altered. The TEM showed ZnO-NP persistence in cytoplasm in both groups. The concentrations of protein and Zn2+ were higher in plasma than in DMEM-EM. In conclusion, the cultivation of hMSCs in plasma compared to DMEM-EM leads to an attenuation of cytotoxicity and genotoxicity in vitro.
Pull-Based Distributed Event-Triggered Circle Formation Control for Multi-Agent Systems with Directed Topologies
Authors: Xu Peng , Zhao Hongfa , Xie Guangming , Tao Jin , Xu Minyi
Published: November 2019

This paper investigates a circle formation control problem for multi-agent systems with directed topologies via pull-based distributed event-triggered control principles. Firstly, for scenarios of continuous communication, a pull-based distributed event-triggered principle is proposed. It is proved that if the communication topology is irreducible and has a directed spanning tree, the event-triggered coupling continuous communication can lead multiple agents to form a desired circle formation. Then, the results are extended to discontinuous communication scenarios, where all the agents use a model of their neighborhoods to generate self-triggered instants without monitoring continuously, update the local controller here, and if necessary, local broadcast information based on the adopted control inputs to neighboring agents. In addition, Zeno behavior can be excluded during the whole process. Finally, numerical simulation results are given to demonstrate the effectiveness of the proposed circle formation control methods.
Intelligent Monitoring of Data Center Physical Infrastructure
Authors: Matko Vojko , Brezovec Barbara , Milanovič Miro
Published: November 2019

This paper presents a new intelligent monitoring and event management method for data center physical infrastructure based on multilayer node event processing. The priorities of highly classified data centers are not only the maintenance of the highest level of reliability and availability of the operation, but also fast, specific event identification and energy consumption monitoring, which altogether improve the level of energy efficiency. The new method, using a tree node for each device, improves information about the events in a specific node. Its major advantage is that in the case of a large number of nodes, it considerably reduces the number of identified events (alarms/alerts) that might be the main cause. Fast event processing lowers data center physical infrastructure operating costs, improving at the same time the level of energy efficiency. The experimental results show that the use of tree nodes significantly reduces the number of unexpected events, the time needed for the main event identification, and the maintenance response time to events. By using event entities processing, multilayer nodes have a significant impact on the efficient operation of data center physical infrastructure.
Experimental and Numerical Study on Mechanical Analysis of Buried Corroded Concrete Pipes under Static Traffic Loads
Authors: Fang Hongyuan , Yang Kangjian , Li Bin , Tan Peiling , Wang Fu , Du Xueming
Published: November 2019

Concrete pipes are widely used in municipal drainage projects. Corrosion is a common issue affecting concrete pipes, causing leakage of pipes, environmental pollution, and road collapse. It is necessary to study the mechanical properties of corroded concrete pipes. To investigate in depth the influence of corrosion depths, corrosion widths, traffic loads, and cover depths, on mechanical characteristics of buried corroded concrete pipes under static traffic loads, a series of full-scale tests were carried out. Then, a three-dimensional finite element model of buried corroded concrete pipes under traffic loads is established based on ABAQUS. Results showed that the inside of the pipe wall is more vulnerable to damage than the outside. The stress and strain of a corroded pipe is significantly larger than that of an uncorroded pipeline. The corrosion has a great influence on the stress and strain of the corroded area. The maximum principal stress and circumferential strain at corroded area increase with increasing of corrosion depth. The stress and strain first increases rapidly (0–10°), and then decreases rapidly (10–45°), then finally decreases slowly (45–180°) with an increase of corrosion width. In addition, the greater cover depth or increasing traffic load causes a rapid increase in both circumferential strain and the maximum principal stress.
Functional Characterization and Genomic Analysis of the Chlorantraniliprole-Degrading Strain Pseudomonas Sp. GW13
Authors: Gao Wa , Li Dongyang , You Hong
Published: November 2019

Chlorantraniliprole (CAP) is a widely used insecticide in many areas due to its excellent insecticidal ability and mammalian safety, however, the removal of CAP has not been extensively studied. In this study, a bacterial strain GW13, which is capable of co-metabolizing CAP, was isolated from a vegetable field soil. The strain was identified as Pseudomonas sp. based on its physico-biochemical characteristics and 16S rRNA gene analysis. The bacterial strain GW13 could degrade CAP through co-metabolism, and glucose was the best additional carbon resource. In the presence of 1.0 g/L glucose, GW13 could co-metabolize over 80% of 200 mg/L CAP in 24 h. The degradation rate increased after 6 h and slowed again after 10 h. The GW13 genome analysis revealed many genes associated with metabolism, showing the degradation mechanism of GW13 from the genomic perspective. The EAWAG-BBD (Swiss Federal Institute of Aquatic Science and Technology Biocatalysis/Biodegradation Database) prediction results showed that the main pathway for CAP degradation is amide hydrolysis, which is consistent with many genes associated with amidase in the GW13 genome. This study may facilitate research on CAP biodegradation mechanisms in the environment.
Lobatamunsolides A–C, Norlignans from the Roots of Pueraria lobata and their Nitric Oxide Inhibitory Activities in Macrophages
Authors: Jo Mun Seok , Yu Jae Sik , Lee Joo Chan , Lee Seoyoung , Cho Young-Chang , Park Hyun-Ju , Kim Ki Hyun
Published: November 2019

Phytochemical investigation of the methanol (MeOH) extract of Pueraria lobata roots, known as “kudzu”, combined with liquid chromatography/mass spectrometry (LC/MS)-based analysis, resulted in the identification of four norlignans (1–4), including three new norlignans, lobatamunsolides A–C (1–3), and five known isoflavonoids (5–9). The structures of the new compounds were elucidated by a combination of spectroscopic methods, including 1D and 2D nuclear magnetic resonance (NMR) and high resolution (HR)-electrospray ionization mass spectrometry (ESIMS), and their absolute configurations were determined by chemical reaction and quantum chemical electronic circular dichroism (ECD) calculations. The isolated compounds (1–9) were evaluated for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Compound 9 displayed the strongest NO inhibitory effect and compound 2 showed a weak effect. The potential mechanism of the effect of compound 9 was investigated by analysis of its molecular docking on the active site of inducible nitric oxide synthase (iNOS), which showed the potential interactions of compound 9 with key amino acid residues and the heme cofactor of iNOS. The mechanism as the inhibition of transcriptional iNOS protein expression was confirmed by western blotting experiments.
The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma
Authors: Faict Sylvia , Oudaert Inge , D’Auria Ludovic , Dehairs Jonas , Maes Ken , Vlummens Philip , De Veirman Kim , De Bruyne Elke , Fostier Karel , Vande Broek Isabelle , Schots Rik , Vanderkerken Karin , Swinnen Johannes V. , Menu Eline
Published: November 2019

Multiple myeloma (MM) is well-known for the development of drug resistance, leading to relapse. Therefore, finding novel treatment strategies remains necessary. By performing a lipidomics assay on MM patient plasma, we aimed to identify new targets. We observed a dysregulation in the sphingolipid metabolism, with the upregulation of several ceramides and downregulation of sphingomyelin. This imbalance suggests an increase in sphingomyelinase, the enzyme responsible for hydrolyzing sphingomyelin into ceramide. We confirmed the upregulation of acid sphingomyelinase (ASM) in primary MM cells. Furthermore, we observed an increase in ASM expression in MM cell lines treated with melphalan or bortezomib, as well as in their exosomes. Exosomes high in ASM content were able to transfer the drug-resistant phenotype to chemosensitive cells, hereby suggesting a tumor-protective role for ASM. Finally, inhibition of ASM by amitriptyline improved drug sensitivity in MM cell lines and primary MM cells. In summary, this study is the first to analyze differences in plasma lipid composition of MM patients and match the observed differences to an upregulation of ASM. Moreover, we demonstrate that amitriptyline is able to inhibit ASM and increase sensitivity to anti-myeloma drugs. This study, therefore, provides a rational to include ASM-targeting-drugs in combination strategies in myeloma patients.
Bioinspired ZnO-Based Solar Photocatalysts for the Efficient Decontamination of Persistent Organic Pollutants and Hexavalent Chromium in Wastewater
Authors: Serrà Albert , Gómez Elvira , Philippe Laetitia
Published: November 2019

Biomimetic/bioinspired engineering and sulfidation processes are effective strategies for improving the visible light-driven photocatalytic performance of ZnO photocatalysts. A facile electrodeposition process in high oxygen-flux conditions was used to synthesize well-defined fractal micro/nanoferns, consequently increasing the photocatalyst’s light-trapping capability and the accessible active surface. Next, a simple sulfidation process was used to form a thin layer of ZnS, producing ZnO@ZnS core@shell micro/nanoferns, thereby tuning the optoelectronic properties and extending the photoresponse to the visible region. The ZnO@ZnS micro/nanoferns exhibited clear superiority over other ZnO photocatalysts in the photooxidation of persistent organic pollutants (POPs) and the photoreduction of Cr(VI). Their excellent photocatalytic performance allowed the photodegradation under UV-filtered sunlight of nearly 97% of methylene blue after 60 min; the mineralization of >98% of a mixture of methylene blue, 4-nitrophenol, and rhodamine-B after 210 min; and the removal of nearly 65% of Cr(VI) after 180 min. In addition, the ZnO@ZnS micro/nanoferns demonstrated a good ability to decontaminate an inorganic-organic bipollutant system, with promising potential to leverage synergistic effects. Finally, these micro/nanoferns presented great recyclability and reusability for both photooxidation and photoremediation processes. These findings support that sulfidation and biomimetic engineering can be a superior route for designing efficient sunlight-driven ZnO-photocatalysts for water decontamination.