bluuebunny/crossref_metadata_2025 huggingface dataset:
The N terminus of Ascl1 underlies differing proneural activity of mouse and Xenopus Ascl1 proteins
Authors: Hardwick Laura J.A. , Philpott Anna
Published: September 2018

The proneural basic-helix-loop-helix (bHLH) transcription factor Ascl1 is a master regulator of neurogenesis in both central and peripheral nervous systemsin vivo,and is a central driver of neuronal reprogrammingin vitro. Over the last three decades, assaying primary neuron formation inXenopusembryos in response to transcription factor overexpression has contributed to our understanding of the roles and regulation of proneural proteins like Ascl1, with homologues from different species usually exhibiting similar functional effects. Here we demonstrate that the mouse Ascl1 protein is twice as active as theXenopusprotein in inducing neural-β-tubulin expression inXenopusembryos, despite there being little difference in protein accumulation or ability to undergo phosphorylation, two properties known to influence Ascl1 function. This superior activity of the mouse compared to theXenopusprotein is dependent on the presence of the non-conserved N terminal region of the protein, and indicates species-specific regulation that may necessitate care when interpreting results in cross-species experiments.
Near-infrared probe-based confocal microendoscope for deep-tissue imaging
Authors: Wang Jiafu , Li Hua , Tian Geng , Deng Yong , Liu Qian , Fu Ling
Published: September 2018

In this work, a near-infrared probe-based confocal microendoscope (pCM) with a 785 nm laser source, a long working distance, and a probe with diameter of 2.6 mm that can be compatible with a conventional endoscope is demonstrated to produce deep-tissue images at cellular resolutions with enhanced contrast and signal-to-noise ratio. Theoretical simulations and experiments confirm that near-infrared light can optimize the image quality. Abundant details of mouse esophagus obtained at different depths demonstrate the system’s ability to image deep tissues at cellular resolutions, which makes it possible to diagnose diseases in the digestive tract in real time, laying a solid foundation for clinical applications.
Scientific and Technological Interventions for Attaining Precision in Plant Genetics and Breeding
Authors: Narain Prem
Published: September 2018

The scientific and technological interventions for attaining precision in plant genetics and breeding since Mendel’s discovery of genetic laws have been critically reviewed in terms of cloning technology and reverse genetics, chip technology, genetically modified organisms and CRISPR-based gene editing technology. Their roles in further refining the plant genetics and breeding practices particularly their exploitation in creating variations and their use for development of superior genotypes in model crops like wheat and rice have been discussed. It is stressed how such interventions could prove to be promising for meeting future crop improvement program in terms of climate change, bio-fortification, imaging technology, statistics, big data revolution and deep learning.
Effect of Nitrogen Fertilizer on some Attributes of SorghumGrown in Saline Soil under Irrigation
Authors: M.Adam Abubaker Haroun , Ahmed Taleim Mohammed
Published: September 2018

The main objective of this study was to investigate the effects of 4 levels of Nitrogen (N) fertilizer (0, 25, 50 and 75 Kg N/fed) on some attributes of Sorghum (Sorghum bicolor L). This study was conducted in the farm of College of Agriculture, University of Bahri-Sudan; during the period 2014-2015. Where the soil is classified as saline with pH ranging from 7.5 -7.8. A randomized completely block designed (RCBD); with 3 replications and four (4) treatments was adopted. All recommended cultural practices were carried out timely. Data; pertaining some plant attributes were collected and analyzed. The result showed that the application of 75KgN/fed has increased both; the average number of leaves as well as the plant height compared to other levels of Nitrogen fertilizer including the control (Figure 1, Figure 2). For the average number of tillers concern, there is non -significant difference between all Nitrogen levels and average number of tillers (Figure 3). The study concluded that the Nitrogen fertilizer has variable effects on the studied agronomic characters, and the application of 75kgN/fed is the optimal level of fertilizer for improving the agronomic traits of Sorghum under Alkadaro conditions.
Discusión
Authors: Zukerfeld Nicolás , Peleteiro Bárbara , Contardi Marilyn , Novak Juan , Moreno Rodrigo , Solarz Malena
Published: September 2018

Los libros de cine: El cine según Hitchcock, de Truffaut

El libro Santa Fe ciudad Set, las revistas Revista de cine y Cuadernos de cine documental
Redes Sociais Corporativas: Avaliação da Centralidade de Grau Através de Índices Como Ferramenta de Gestão.
Authors: Gulini Aldérico Silvio , Misaghi Mehran
Published: September 2018

As redes sociais online estão se tornando cada vez mais populares,  já tomam conta de boa parte dos conteúdos da Web, suas aplicações encontram-se presentes em nossa rotina através do compartilhamento de informações e engajamento de grupos com afinidades comuns. Esta nova forma de comunicação  vem chamando a atenção de muitas organizações, onde se percebe um grande movimento organizacional fazendo com que muitas empresas iniciem uma busca por aplicações que forneçam possibilidades de interação  entre funcionários, clientes e até mesmo fornecedores no ambiente corporativo. A proposta deste artigo é levantar uma breve discussão sobre a utilização das redes sociais nas organizações, identificar as dificuldades quanto a manipulação e gerenciamento de um grande volume de informações. Demonstrar a importância da análise estatística através de suas propriedades como ferramenta para auxiliar a correta tomada de decisão fazendo uso e comparações sob o aspecto de três índices de avaliação.
Técnicas de Engenharia do Conhecimento como apoio à Memória Organizacional
Authors: Nazario Debora Cabral , Rotta Maurício José Ribeiro , Dantas Mário Antônio Ribeiro
Published: September 2018

Este artigo tem por objetivo fazer uma revisão de literatura sobre as técnicas de Engenharia do Conhecimento (EC) como apoio aos processos de Memória Organizacional (MO) - aquisição, armazenamento, manutenção, busca e recuperação de conhecimento. A metodologia de estudo consistiu das etapas de coleta de dados na literatura, análise, síntese e estruturação do conteúdo. Os procedimentos metodológicos da coleta de dados são detalhados, seguido pelos aspectos conceituais relacionados a MO - informação armazenada sobre o passado de uma organização e que pode contribuir nas decisões presentes. Em seguida, é abordado o termo EC, são definidas algumas de suas técnicas e apresentados alguns trabalhos que utilizam EC para apoiar a MO. A memória organizacional se apresenta como um dos principais repositórios de conhecimento e, portanto, o aprimoramento de seus processos por meio de técnicas de EC, tornou-se essencial para as organizações realizarem a efetiva Gestão do Conhecimento. As organizações podem ser beneficiadas pelas técnicas de EC através de uma melhor aquisição, representação e recuperação do conhecimento da MO.
Blood profile and gut microbial load of broilers fed siam weed (Chromolaena odorata) leaf meal in their diets
Authors: Jiwuba Peter-Damian Chukwunomso , Ogbuewu Ifeanyi Princewill , Dauda Elisha , Azubuike Caritas Chibuike
Published: September 2018

The responses of 96 day old broilers fed Chromolaena odorata leaf meal (COLM) on blood profile and gut microbial load were studied for 49 days. The birds were randomly assigned to four treatment groups and replicated three times in a completely randomized design. The birds were fed four experimental diets formulated at 0%, 2%, 4% and 6% for the starter phase and 0%, 4%, 8% and 12% of COLM at the finisher phase for T1, T2, T3 and T4 respectively. All the haematological parameters were similar (P>0.05) across the treatment groups except MCH and WBC which were significantly (P< 0.05) higher and better in the treatment groups than the control group. The results on serum chemistry showed significant (P<0.05) difference for total protein, albumin, creatinine and cholesterol across the treatment groups. Cholesterol was significantly (P<0.05) reduced with increasing levels of COLM. Results showed that coliforms and E.coli were consistently higher (P<0.05) among the T1 birds than those fed T2, T3 and T4. It was concluded that, COLM enhanced adequate haematocrit and immune status, hypoglycaemic ability, suppresses the growth of gut pathogenic microorganisms and enhanced the growth of beneficial microorganism in broilers.
Yield performance and agronomic efficiency in oil pumpkins (Cucurbita pepo L. group Pepo) depending on production systems and varieties
Authors: Jakop Manfred , Grobelnik Mlakar Silva , Bavec Martina , Robačer Martina , Vukmanič Tjaša , Lisec Urška , Bavec Franci
Published: September 2018

In 2013 and 2014, a long-term trial (which was established in 2007) was conducted at the University Agricultural Centre in Pivola near Hoče. It included different production systems (conventional, integrated, organic, biodynamic), carried out in a field trial with oil pumpkins. The aim of the research was to analyse the effects of different production systems, varieties (hybrid and population variety) and years of production, on formation of oil pumpkin yields. The agricultural practice has been carried out in accordance with the applicable legislations and standards for the individual production system. When sowing, before fertilizing with nitrogen in early June and after the harvest, the amount of soil mineral nitrogen was monitored. We evaluated the number and weight of harvestable, unripe and decayed fruits, and yield of oil seed pumpkins and calculated the agronomic efficiency of the applied nutrients. The results showed that the year of production, the production system and the variety have a significant effect on some fruit characteristics and the yield of oil pumpkin seeds. The content of soil mineral nitrogen in May and September was significantly influenced by the production system and the year. In June, only the production system had a significant effect. The hybrid significantly increased the yields of oil pumpkin seeds in all production systems, even in the year that was less suitable for production. The agronomic efficiency of the applied nutrients in the biodynamic and organic production system is higher or equal than in the conventional production system, similarly, agronomic efficiency is higher in the hybrid compared to the oldest population variety efficiently. A comparable oil pumpkin yield can be expected in biodynamic and organic production, when proper nutrition and well carried out cultivation practices are combined with a new variety, when compared to less sustainable production systems, which often cause damage to the environment.
Geotourism and Mining Heritage: a Potential Gold Mine for Central Nigeria
Authors: Goki Nathaniel G. , Iyakwari Shekwonyadu , Umbugadi Allu A.
Published: September 2018

The potential for geotourism and mining heritage of some landscapes in parts of Kaduna, Plateau, Nasarawa and Kwara states in central Nigeria were studied and compiled. The result show that geological endowments range from insalbergs, flood basalts and dome structures, which presents natural landscape for tourism. The quartzite ridges of the Oreke area in Ilorin host the Owu Falls of 120m cascading waters, the Kafanchan flood basalts that flowed extensively from the Kagoro hills with extensive columnar jointing creating the prestigious water falls of over 30m all present versed potential for geotourism. Mining activity around the Jos Plateau (Bassa, Jos, Bukuru, Barakin Ladi and Bokkos areas), southern Kaduna (Godogodo and Jagindi) create landscapes that if properly beautified can become tourist landmarks. Adopting and harnessing these landscapes can boost and provide alternative revenue for the affected central.
The transverse arch collapse correction as a path to foot toes alignment
Authors: Dygut Jacek , Piwowar Piotr , Kogut Wojciech , Boroń Wiktor , Piwowar Monika
Published: September 2018

The study presents a fragment of pilot studies showing the reconstruction of the transverse arch of the foot using a specially constructed orthosis for this purpose. It involves the mechanical reinforcement of the effect by an orthosis, which pushes down the I, IV, and V metatarsal bones while elevating or blocking the fall of the near-immobile II and III metatarsal bones according to the “three-force” rule. The correction of the transverse arch of the foot runs simultaneously with the correction of hallux valgus (HV). As a result, the significant correction of HV and associated toe deformities was achieved. In stage I foot deformity, the reduction of HV was reduced from 19.1° before to 15.1° after putting on orthosis (p = 0.024). In stage II, the reduction was from 20.1° (before) to 16.2° (after; p = 0.032). Equally satisfactory results were obtained for the remaining angles of the metatarsal bones. In the future, the method can be suitable for patients undergoing preparation for corrective HV surgery and for maintaining postoperative HV results. It can be used preventively, for example, by women who frequently wear high-heeled shoes and by those who need to remain standing for prolonged periods of time.
Modeling Completion of Vocational Education: The Role of Cognitive and Noncognitive Skills by Program Type
Authors: Stratton Leslie S. , Datta Gupta Nabanita , Reimer David , Holm Anders
Published: September 2018

This study provides evidence of the importance of cognitive and noncognitive skills to completion of three types of vocational training (VET): education and health, technical, and business. Math and language exam scores constitute the key measures of cognitive skills; teacher-assigned grades the key measure of noncognitive skills. The data consist of two 9-year panels of youth completing compulsory education in Denmark. Estimation of completion proceeds separately by gender and VET type, controlling for selection and right censoring. The authors find that all skills are inversely related to VET enrollment, even controlling for family-specific effects. Estimates for completion vary considerably by program type, demonstrating the methodological importance of distinguishing among different VET courses. Math scores are positively related to certification for all VET tracks, though with very different magnitudes; language skills are inversely related for the nonbusiness tracks; and noncognitive skills appear important primarily for the business track.
Discretion rather than rules? Outdated optimal commitment plans versus discretionary policymaking
Authors: Jensen Christian
Published: September 2018

Because optimal plans are time-inconsistent, continuing one from a previous period is not optimal from today’s perspective, and may not outperform discretion, even ignoring surprise deviations. Hence, a once-and-for-all commitment to the optimal plan from a particular period does not always outperform discretion over time, even if superior from the perspective of the original period. Forward-looking policymakers might therefore not want to bind themselves to the optimal plan from any period. The vast literature on commitment strategies illustrates that it is a common misconception that a once-and-for-all commitment to the optimal plan is always preferable to discretion.
Corneal Perforation in a Patient with Chronic Keratouveitis and Gout: Case Report
Authors: Partojeva Rita , Elksnis Eriks , Laganovska Guna
Published: September 2018

The ophthalmic manifestations of gout are rare. There are only few published reports and study about it. The majority of patients with ocular gout abnormalities are asymptomatic. The authors discuss the case of a 43-year-old male who presented with central corneal keratolysis with perforation. The patient has an approximately 14-year history of gout attacks and chronic keratouveitis witch started about the same time. Coincidence of keratouveitis in a patient with gout has not been reported and it is unclear if this condition is rare or may only be by chance at the same time with gout.
Total Corneal Transplantation after Trauma
Authors: Silina Elina , Laganovska Guna
Published: September 2018

The first successful corneal transplantation is known since 1905, performed by Eduard Zirm (2). It has been implemented in order to restore vision in a variety of corneal diseases and after ocular traumas. The traditional technique for corneal transplantation, penetrating keratoplasty (PKP), refers to the full-thickness replacement of corneal tissue with a healthy donor graft (1). Authors report a well-documented case about successfully transplanted cornea after penetrating ocular trauma to improve visual outcome.
Passion and Creativity – Together or Separately?
Authors: Kunat Beata
Published: September 2018

In this paper I will attempt to compare two categories of passion and creativity. I will try to answer the question: What has passion got in common with creativity? What is the common denominator and what is different? What is the role of passion in the creative process? Searching for the mechanism of passion and its components is necessary to discover its relation to creativity I will refer to passion psychology (Vallerand, 2015). The basis of my analysis will be the Dualistic Model of Passion (Vallerand et al., 2003; Vallerand 2008, 2010, 2015), the concept of Grit: The Power of Passion and Perserverance (Duckworth et al., 2007; Duckworth & Quinn, 2009, Duckworth 2016) and the concept of Flow (Csíkszentmihályi, 1996). In the process of mapping the areas that connect passion with creativity I will refer to four ways of its understanding: creativity as a process, a personality trait complex, a product and the interaction between the creative individual and the context or environment. I will also refer in my comparisons to The four C Model of Creativity (Kaufman & Beghetto 2009).
The Four Ps of Creativity in the Drama/Theatre Project Jutka’s Sleeplessness
Authors: Witerska Kamila
Published: September 2018

The text is a case study report concerning research on a drama/theatre project called Jutka’s Sleeplessness that was performed in the public space of Łódź. The purpose of the research was to address the question of how this creative - new and valuable product - in the form of the drama/ theatre project Jutka’s Sleeplessness was created and what aspect of creativity decides on the success of a project that combines drama with theatre. The discussion represents an attempt to demonstrate how the four Ps of creativity work in a drama/theatre project.
Violence depicted in advertisements on LinkNYC kiosks in Manhattan, New York City
Authors: Basch Corey Hannah , LeBlanc Michael , Ethan Danna , Basch Charles E.
Published: September 2018

Violence has a profound negative impact on the lives of youth. Exposure to violence may be a precursor to violence later in life. The purpose of this study was two-fold: (1) to estimate the prevalence of violence depicted in advertisements on LinkNYC kiosks in Manhattan, NYC, and (2) to determine if violent advertising varied based on the median annual income of the zip code in which the kiosk was located. This cross-sectional study involved observations of advertisements on 100 LinkNYC kiosks that were selected randomly from 500 that were listed in Manhattan, NYC. The frequency and type of violent depictions were recorded. The kiosks were grouped into quartiles of median annual income (1) $40,782 and below (2) $40,783 to $86,801 (3) $86,802 to $105,500 and (4) $105,501 and above. Of the 2025 total advertisements observed, including duplicates, a total of 190 (9.4%) included violent content. These 190 advertisements were observed on 68 of the 100 kiosks and included 339 depictions of violence. The overwhelming majority (n = 136; 71.6%) of violent depictions were for movies. There were significant differences in the frequency of violent content based on income quartiles, χ2 (3, n = 190) = 19.00, p < 0.001. The highest two income quartiles had fewer violent advertisements than would be expected and the lowest quartile had more violent advertisements than expected. Symbols of violence were the most frequent type of violence portrayed observed in 85% of the violent advertisements observed (n = 161). Weapons, crime and fighting were observed in 5–11% of the advertisements. Our study suggests that greater alignment between the city’s aims to improve community health and reduce health disparities and advertising policies on LinkNYC warrants consideration.
Methanol to Gasoline Conversion over CuO/ZSM-5 Catalyst Synthesized Using Sonochemistry Method
Authors: Kianfar Ehsan , Salimi Mahmoud , Hajimirzaee Saeed , Koohestani Behnam
Published: September 2018

In this research, the catalytic conversion of methanol to gasoline range hydrocarbons has been studied over CuO (5 %)/ZSM-5 and CuO (7 %)/ZSM-5 catalysts prepared via sonochemistry methods. Conversion of methanol to gasoline (MTG) has been carried out in a fixed bed reactor under atmospheric pressure and 400˚C temperature, over copper oxide on the synthesized ZSM-5 catalyst. The samples were characterized by XRD, SEM, TEM, BET, and FTIR techniques; in which good crystallinity and high specific surface area of synthesized zeolite were proved after impregnation of zeolite with copper. The present investigation suggests that the CuO/ZSM-5 catalyst made by sonochemistry method can increase the yield toward hydrocarbon production. It was concluded that impregnation of zeolite with copper oxide can alter the Brønsted/Lewis acid sites ratio and provide new Lewis acid sites over the surface of the ZSM-5. The main products of methanol to gasoline reaction over the catalyst that prepared via sonochemistry method were toluene, xylene, ethylbenzene, ethyl toluene, tetra methylbenzene, diethyl benzene and butylbenzene. The total amount of aromatics in the products was 80 % by using this catalyst. Our results suggest that catalyst synthesized by using sonochemistry shows better production yield toward hydrocarbons by affecting the distribution of active sites on the surface of the ZSM-5.
Acoustic phonons in nanowires probed by ultrafast pump-probe spectroscopy
Authors: Mante Pierre-Adrien , Belliard Laurent , Perrin Bernard
Published: September 2018

The fascinating relationship between structure and property in nanowires has enabled a wealth of applications in photonics and electronics. The behavior of phonons in nanowires is also modified compared to their bulk counterparts. In this review, we provide an overview of the recent efforts to investigate the properties of acoustic phonons in nanowires using ultrafast optical methods. In particular, we focus on the calculation of the modified phonon dispersion in nanowires and how to address them optically. We then discuss experimental investigations in arrays of nanowires and a single nanowire. The analysis of phonon behavior reveals the possibility to perform advanced mechanical characterization and to vary the thermal properties of nanowires. The review concludes with a brief perspective on future research directions, from phonon-induced control over properties to three-dimensional (3D) acoustic nano-imaging.
Silent enhancement of SERS signal without increasing hot spot intensities
Authors: Postaci Selen , Yildiz Bilge Can , Bek Alpan , Tasgin Mehmet Emre
Published: September 2018

Plasmonic nanostructures enhance nonlinear response, such as surface enhanced Raman scattering (SERS), by localizing the incident field into hot spots. The localized hot spot field can be enhanced even further when linear Fano resonances take place in a double resonance scheme. However, hot spot enhancement is limited with the modification of the vibrational modes, the breakdown of the molecule, and the tunneling regime. Here, we present a method which can circumvent these limitations. Our analytical model and solutions of 3D Maxwell equations show that: enhancement due to the localized field can be multiplied by a factor of 102–103. Moreover, this can be performed without increasing the hot spot intensity which also avoids the modification of the Raman modes. Unlike linear Fano resonances, here, we create a path interference in the nonlinear response. We demonstrate on a single equation that enhancement takes place due to cancellation of the contributing terms in the denominator of the SERS response. Our method can be implemented on an atomic force microscope tip, decorated (or “contaminated”) with appropriate quantum emitters.
Lattice effect influence on the electric and magnetic dipole resonance overlap in a disk array
Authors: Babicheva Viktoriia E. , Moloney Jerome V.
Published: September 2018

Designing the shape of silicon nanoparticles has been shown to be an effective approach to increasing overlap between electric and magnetic dipole resonances thereby achieving directional scattering and decrease of reflection. Variations of disk diameter and/or height affect resonances differently and can thus result in resonance overlap. In most of the studies, the disks are arranged in a periodic array where the periodicity is varied together with disk diameter, but the role of lattice effect is neglected. Here we theoretically study a periodic array of disks and show that the contribution of the lattice effect in shifting resonance positions is comparable to the effect of the diameter change. We demonstrate that the lattice effect is important even when the wavelength of diffraction remains on the blue side from electric and magnetic dipole resonances and there are no additional lattice resonances excited. Period and disk dimensions are chosen so that the resonances overlap in the proximity of the telecommunication wavelength which is of great practical interest.
Following the Code: Spillovers and Knowledge Transfer
Authors: Gandal Neil , Naftaliev Peter , Stettner Uriel
Published: September 2018

Knowledge spillovers in Open Source Software (OSS) can occur via two channels: In the first channel, programmers take knowledge and experience gained from one OSS project they work on and employ it in another OSS project they work on. In the second channel, programmers reuse software code by taking code from an OSS project and employing it in another. We develop a methodology to measure software reuse in a large OSS network at the micro level and show that projects that reuse code from other projects have higher success. We also demonstrate knowledge spillovers from projects connected via common programmers.
The Rise of Streaming Music and Implications for Music Production
Authors: Hiller R. Scott , Walter Jason M.
Published: September 2018

In this paper, we model the potential for streaming music, a non-durable product, to upend and displace durable music sales. As the popularity of streaming music increases producers will adjust their production to focus on the non-durable channel. We identify conditions under which the changes in music delivery will encourage musicians to release fewer songs, but at a higher quality, leading to market deepening and increased engagement. This change will complete the unbundling process in music production making the traditional bundled album of little importance. This tendency toward unbundling for individual musicians depends on a robust bundle from a delivery platform to provide value for consumer subscriptions. Beyond a model of consumer utility and producer profit, we analyze the most played songs of the large streaming music platform, Spotify, and compare those results to traditional album sales using Nielsen data.
Closed-form estimators for finite-order ARCH models as simple and competitive alternatives to QMLE
Authors: Prono Todd
Published: September 2018

Strong consistency and (weak) distributional convergence to highly non-Gaussian limits are established for closed-form, two stage least squares (TSLS) estimators of linear and threshold ARCH (p) models, with special attention paid to the ARCH (1) and threshold ARCH (1) cases. Conditions supporting these results include (relatively) mild moment existence criteria that enjoy empirical support. These conditions are not shared by competing estimators like OLS. Identification of the TSLS estimators depends on asymmetry, either in the model’s rescaled errors or in the conditional variance function. Monte Carlo studies reveal TSLS estimation can sizably outperform quasi maximum likelihood (QML) in small samples and even best recently proposed two-step estimators specifically designed to enhance the efficiency of QML.
Feasibility of Developing Engineered Cementitious Composite with High Volumes of Fly Ash Using Cost-Effective PVA Fiber
Authors: Ji Jing , Zhang Shilong , Jiang Liangqin , Zhou Lijian , Xu Zhichao , Liu Yingchun , Yu Dianyou
Published: September 2018

In order to reduce the cost of Engineered Cementitious Composite (ECC), a feasibility study of ECC using a Cost-Effective Polyvinyl Alcohol (PVA) fiber (CEPVA-ECC) was developed based on the micromechanical design theory. A set of ECCs with different amounts of fly ash replacement (up to 83 % replacement of cement) was prepared. The CEPVA-ECC using much cheaper Chinese domestic PVA fiber (1/6–1/4 the price of the imported fiber) maintained the tensile ductility characteristics (4–5 %) with a moderate compressive strength (30–40 MPa). The crack width was reduced with an increase of the fly ash amount. The strain map CEPVA-ECC was monitored by the Digital Image Correlation method.
Marketing menadžment u sportu - primjer dubrovačkih sportskih klubova
Authors: Peručić Doris , Joković Maro
Published: September 2018

Marketing ima ključnu ulogu u društvu kao cjelini. Sportski marketing obuhvaća sve procese za stvaranje i isporuku vrijednosti i prenošenje poruke o njoj polazeći od specifičnih uvjeta u kojima se formiraju odnosi među tržišnim subjektima i utječe na uspjeh sportskih klubova i sportskih događaja. U velikom broju sportskih klubova još uvijek nema sustavne primjene marketinga. U radu se istražuje primjena marketinga u dubrovačkim sportskim klubovima i stupanj razvijenosti svijesti menadžmenta o potrebi prihvaćanja marketinga kao poslovne filozofije. Istraživanje je provedeno metodom ispitivanja pomoću dubinskog intervjua s čelnim ljudima najuspješnijih dubrovačkih sportskih klubova i s tajnikom DSŠ-a športova. Izneseni su uzroci neprovođenja planiranja i sustavne primjene marketinga u sportskim ustanovama u Dubrovniku, dosadašnje aktivnosti marketinškog djelovanja, problemi s kojima se susreću te su dane smjernice za bolje razumijevanje važnosti marketinga u sportu. Istraživanje je potvrdilo da nema sustavne primjene marketinga u sportskim ustanovama u Dubrovniku i da se aktivnosti marketinškog djelovanja svode uglavnom na razne oblike marketinške komunikacije s ciljnim tržišnim segmentima. Svijest menadžmenta o važnosti sportskog marketinga postoji, čelnici klubova i saveza ističu potrebu uspostave marketinških odjela unutar klubova, ali u praksi to još uvijek nije realizirano. Uz nedostatak financijskih sredstava, nedovoljno razumijevanje marketinga kao filozofije poslovanja jedan je od glavnih razloga neprovođenja sustavne primjene marketinga u sportskim ustanovama. Za uspješno upravljanje marketingom u sportskim ustanovama ključno je angažirati stručnjaka/voditelja sportskog marketinga te voditi računa o tome da je to pothvat na razini cijelog kluba koji pokreće njegovu viziju, misiju i strateško planiranje.
Implementasi Kurikulum 2013 di Sekolah Pesantren dengan Sistem Boarding School
Authors: Paminto Joko , Rosiana Tina , Budiyono Budiyono , Budisantoso Heri Triluqman
Published: September 2018

The existence of formal schools under Pesantren (traditional Islamic education) foundation is interesting, because they have unique characters comparing to other schools in general, whereas each Pesantren has its own peculiarity. One of them is Senior High School of Selamat Modern Pesantren, Kendal. This article describes the implementation of Curriculum 2013 in that school based on qualitative research in 2017. The research result indicated that the implementation of Curriculum 2013 established an integrated curriculum from national Curriculum 2013, learning materials from Ministry of Religious aﬀair and unique vision of the modern Selamat Pesantren itself. So there was a combination between the Curriculum 2013, the materials form Ministry of Religious aﬀair which is more Islamic in nature and the programs from boarding system that enrich the student character building and knowledge. Moreover, in this research teachers are central regarding to their position as student’s facilitator and companion, particularly those who actively accompany the dormitory activities.

Abstrak

Keberadaan sekolah-sekolah formal di bawah naungan yayasan pesantren menarik untuk dikaji, karena pasti memiliki kekhasan tersendiri dibanding sekolahsekolah lain pada umumnya. Terlebih tiap pesantren memiliki kekhasan masingmasing. Salah satu modelnya adalah di Sekolah Menengah Atas Pondok Modern Selamat, Kendal. Artikel ini menggambarkan implementasi Kurikulum 2013 di sekolah tersebut didasarkan pada penelitian berpendekatan kualitatif yang telah dilaksanakan pada 2017. Hasilnya menunjukkan bahwa implementasi Kurikulum 2013 di SMA Unggulan Pondok Modern Selamat, Kendal, menunjukkan karakteristik unik berupa kurikulum yang terpadu antara kurikulum nasional, muatan materi dari Kementerian Agama (Kemenag), dan visi khas dari yayasan pondok pesantren Selamat. Dengan demikian terdapat kombinasi antara orientasi Kurikulum 2013 yang bersifat umum, materi dari Kemenag yang berorientasi memberi bekal ilmu-ilmu keislaman, dan ditunjang oleh program di asrama yang memperkaya pembentukan karakter siswa dan pengayaan penguasaan pengetahuan siswa. Lebih lanjut, guru perannya sangat sentral dalam implementasi kurikulum yang terpadu di sekolah ini karena diposisikan sebagai pendamping siswa, terutama guru-guru yang juga aktif mendampingi kegiatan asrama.

Keywords:  Boarding school; curriculum implementation; curriculum evaluation; curriculum plan; national curriculum
Primary Cardiac Sarcoma Remission after Surgery: 5-Years Follow-up: Case Report
Authors: Teker Melike Elif , Teskin Önder
Published: September 2018

Background: Primary cardiac sarcoma is a rare and atypical clinical entity. We present a patient with long-term remission after primary cardiac sarcoma resection.

Case Report: A 42-year-old previously healthy female presented to the emergency department after an effort-induced 30-minute episode of chest pain and extreme shortness of breath. Physical examination upon admission was remarkable for a pulse of 99/minute; blood pressure was 101/73 mmHg. Transthoracic echocardiography showed a mass measuring 5.5 × 5.6 cm extending from the left septum to the mitral valve anterior leaflet. A multilobulated broad-based 5.5 × 5.6 × 4 cm3 mass invading a large portion of the left septum to the mitral valve anterior leaflet was completely excised in the open heart surgery. Chemotherapy regimen (paclitaxel 175 mg/m2/day on day 1, every 21 days) was started after operation. Full remission was provided. Metastasis and recurrence have not been observed for 5 years of follow-up by PET. We observed during 5 years and used a PET. And the finally we did not see metastasis at the 5 years of follow-up.

Conclusions: We strongly recommend that a patient-specific multidisciplinary approach involving radical resection, chemotherapy, and radiation therapy in these cases results in patient survival and a significant improvement in quality of life. We also think that it is necessary to perform MRI to exclude other illnesses that are considered to be a myxoma.
Ras-Dependent Cell Fate Decisions Are Reinforced by the RAP-1 Small GTPase in Caenorhabditis elegans
Authors: Rasmussen Neal R , Dickinson Daniel J , Reiner David J
Published: September 2018

Investigation into the signaling relationship between closely related small GTPases Ras and Rap1 has a complicated past. Rasmussen, Dickinson, and Reiner use Caenorhabditis elegans to investigate the role of RAP-1 in LET-60/ Ras-dependent developmental events...

The notoriety of the small GTPase Ras as the most mutated oncoprotein has led to a well-characterized signaling network largely conserved across metazoans. Yet the role of its close relative Rap1 (Ras Proximal), which shares 100% identity between their core effector binding sequences, remains unclear. A long-standing controversy in the field is whether Rap1 also functions to activate the canonical Ras effector, the S/T kinase Raf. We used the developmentally simpler Caenorhabditis elegans, which lacks the extensive paralog redundancy of vertebrates, to examine the role of RAP-1 in two distinct LET-60/Ras-dependent cell fate patterning events: induction of 1° vulval precursor cell (VPC) fate and of the excretory duct cell. Fluorescence-tagged endogenous RAP-1 is localized to plasma membranes and is expressed ubiquitously, with even expression levels across the VPCs. RAP-1 and its activating GEF PXF-1 function cell autonomously and are necessary for maximal induction of 1° VPCs. Critically, mutationally activated endogenous RAP-1 is sufficient both to induce ectopic 1°s and duplicate excretory duct cells. Like endogenous RAP-1, before induction GFP expression from the pxf-1 promoter is uniform across VPCs. However, unlike endogenous RAP-1, after induction GFP expression is increased in presumptive 1°s and decreased in presumptive 2°s. We conclude that RAP-1 is a positive regulator that promotes Ras-dependent inductive fate decisions. We hypothesize that PXF-1 activation of RAP-1 serves as a minor parallel input into the major LET-60/Ras signal through LIN-45/Raf.
La sirvienta y el luchador. Una interpretación
Authors: Rojas Margarita , Ovares Flora
Published: September 2018

Este estudio se refiere a la cuarta novela de la serie sobre la familia Aragón, que Horacio Castellanos Moya empezó en 2003 y finalizó en 2013. Todas cuentan la historia política de El Salvador desde 1944 y en casi todas se menciona un acontecimiento: el secuestro y el asesinato de Alberto Aragón hijo, que finalmente se narra en La sirvienta y el luchador. Esto se lleva a cabo con una aparente simplicidad, que esconde una hábil manipulación de los recursos narrativos. Esa complejidad textual requiere una interpretación que vaya más allá de la referencia histórica y rescate el valor literario del texto
Objetivos de desarrollo sostenible y el control de enfermedades
Authors: Cabezas-Sánchez César
Published: September 2018

El año 2000, 189 naciones del mundo formularon el plan denominado “Objetivos de Desarrollo del Milenio (ODM)” y se unieron para enfrentar el futuro que tenía que ver con hambrunas, sequías, guerras, plagas, pobreza y problemas crónicos en el mundo. Se sabía que teníamos suficiente comida para alimentar al mundo, pero que no estaba siendo compartida; que se tenían medicamentos para el VIH y para otras enfermedades, pero que eran muy costosos; que los terremotos y las inundaciones eran inevitables, pero no así la elevada cantidad de muertos. Se hicieron planes ambiciosos, como para erradicarlos en poco años. Surge entones en el año 2015 el acuerdo de las naciones por los Objetivos de Desarrollo Sostenible (ODS)1.
Vitamina D y su relación con factores de riesgo metabólicos para enfermedad cardiovascular en mujeres adultas
Authors: Pajuelo Ramírez Jaime , Bernui Leo Ivonne , Arbañil Huamán Hugo , Gamarra González Dante , Miranda Cuadros Marianella , Chucos Ortiz Rafael
Published: September 2018

Introducción. La deficiencia de vitamina D es considerada como un problema de salud pública en otros países. Se ha reportado que esta deficiencia se relaciona con el riesgo a desarrollar enfermedades metabólicas Métodos. Estudio descriptivo, transversal, en 110 mujeres adultas de Lima Metropolitana. Se calculó el índice de masa corporal (IMC) para definir el estado nutricional. Se determinó niveles de insulina, glucosa, perfil lipídico y 25(OH)-D (vitamina D). Se calculó el Homeostatic Model of Assesment Index (HOMA-I). Para definir resistencia a la insulina (RI) se consideró un HOMA-I ≥ 2,7. Para la deficiencia de la 25 (OH)-D el punto de corte fue 30 ng/mL. Para la ingesta de vitamina D se usó la frecuencia de consumo. La identificación de dislipidemias se hizo con lo recomendado por el Third Report of the National Cholesterol Education Program. Resultados. En las pacientes con déficit de vitamina D, los promedios de edad, IMC, insulina, glucosa, HOMA-I, colesterol total, colesterol HDL, colesterol LDL, y trigliceridos fueron superiores respecto a las pacientes con dosaje de vitamina D normal, encontrándose diferencia estadísticamente significativa para el IMC (p<0,03), niveles de insulina (p<0,01), HOMA-I (p<0,01), y trigliceridos (p<0,01). Además, se determinó déficit de vitamina D en pacientes con resistencia a la insulina con la presencia de obesidad y sobrepeso así como en las pacientes con hipertrigliceridemia (p<0,05); el riesgo de tener déficit de esta vitamina estuvo asociado a resistencia a la insulina (OR:3,28; IC:1,3-8,3) y con hipertrigliceridemia (OR:4,07; IC:1,8-9,3). Conclusiones. La deficiencia de vitamina D mostró asociación con dos variables que identifican el riesgo metabólico: la resistencia a la insulina y la hipertrigliceridemia, en la población estudiada, lo que podría explicar la posible relación de esta vitamina con enfermedades cardiovasculares.
Características del estado periodontal en gestantes del Hospital Materno Infantil San Pablo de Asunción, Paraguay
Authors: Méndez Báez María Gisselle , Pérez Bejarano Nohelia María
Published: September 2018

Objetivo: Determinar las características del estado periodontal en gestantes que acudieron al Hospital Materno Infantil San Pablo (HMISP) de Asunción, Paraguay en el periodo comprendido entre diciembre del 2015 a febrero del 2016. Métodos: Se realizó un estudio observacional descriptivo de corte transversal a pacientes embarazadas que asistieron a su primera consulta prenatal. Se aplicó una encuesta sobre factores sociodemográficos, hábitos de higiene oral e instrucción de salud bucal por parte del personal de salud. La evaluación del estado periodontal se realizó en una hoja de registro de datos clínicos, que incluyó el índice gingival (IG) de Löe y Silness en dientes del sextante anteroinferior. Resultados: Se evaluaron a 96 pacientes con edades comprendidas entre 15 y 37 años, con una media de 23,8, desviación estándar 5,47. Se evidenció que la gingivitis predominó en las gestantes en un 85,4% (n=82). La gingivitis moderada fue la manifestación más frecuente (49%), tanto en el primer como el tercer trimestre, en tanto que la gingivitis severa se presentó en menor proporción (3,1%). Conclusiones: La gingivitis predominó en las gestantes en un 85,4%, siendo más frecuente la gingivitis moderada en un 49% según lo registrado con el IG de Löe y Silness.
El consumo digno y los negocios de app de taxi (caso Uber)
Authors: Armas Morales Carlos Eduardo
Published: September 2018

El presente artículo, dentro del marco actual de la denominada economía colaborativa, evalúa si las app de taxis (Uber) que ofertan servicios en el Perú (Lima), lo hacen concordando con los principios mínimos del consumo digno, es decir si brindan un buen servicio de transporte de taxi, teniendo en cuenta que en Europa estos servicios han sido clasificados dentro del transporte público de taxis (Sentencia del Tribunal Europeo el año 2017). Y de otro lado, existe el debate en Latinoamérica, incluido el Perú de regular estos servicios (se presentaron dos proyectos de ley en el 2017) , lo que nos convoca a una revisión teórica dentro del marco del derecho económico y contractual peruano, evaluando siestas cumple con el consumidor: usuario-cliente, con la garantía de una seguridad adecuada al resguardo de su vida, salude integridad psíquica física, es decir si el servicio es seguro para el usuariocliente, en el sentido de tener un trato digno en su consumo y dado los hechos delictivos (robos, intentos de violación y secuestros etc.) que han ocurrido y ocurren en Lima en la prestación de este servicio, no obstante creemos que este estudio reflejaría lo que ocurre en otros lugares del Perú.
Habilidades del pensamiento y rendimiento académico en estudiantes universitarios de las carreras de Ingeniería y Arquitectura
Authors: Arias Barahona Guzmán Rosario , Aparicio Pereda Ana Sofía
Published: September 2018

El estudio buscó establecer la relación entre las habilidades del pensamiento y de sus factores con el rendimiento académico en un grupo de ingresantes universitarios de las carreras de Ingeniería y Arquitectura. La muestra total fue de 113 participantes, con la que se hicieron todos los análisis referentes a las habilidades del pensamiento, distribución de factores y niveles. El análisis de relación entre rendimiento académico y habilidades del pensamiento se realizó con 98 participantes que contaban con los promedios finales de notas. Los resultados muestran que los participantes se distribuyen mayoritariamente en el nivel Normal Inferior al Normal y la existencia de una asociación positiva moderada con el rendimiento académico. No se encontraron diferencias de acuerdo al género, edad y/o especialidad.
Planejamento e execução de um inquérito populacional de saúde por meio de consórcio de pesquisa multidisciplinar
Authors: Dumith Samuel Carvalho , Paulitsch Renata Gomes , Carpena Marina Xavier , Muraro Monica de Fátima Rossato , Simões Milena de Oliveira , Machado Karla Pereira , Dias Mariane da Silva , Kretschmer Andressa Carine , Oliz Manoela Maciel , Pontes Leandro da Silveira , Susin Lulie Rosane Odeh
Published: September 2018

AIMS: To describe the methodological and operational aspects of a health survey, conducted by means of a multidisciplinary research consortium.METHODS: A cross-sectional, population-based study was conducted with individuals 18 years or older, living in the urban area of the municipality of Rio Grande, in Rio Grande do Sul state, Brazil. The sampling was probabilistic, with census tracts as the primary sample unit. The research instrument consisted of a standardized and previously tested questionnaire, with closed questions, applied by face-to-face in dwellings. A brief questionnaire was administered to 10.5% of subjects for quality control purposes. Fieldwork lasted from April to July 2016, and the study was approved by an ethics committee.RESULTS: Of the 70 sampled census tracts, 711 households were randomly selected, comprising 1,429 eligible individuals. Overall, 1,300 individuals (91.0%) of 676 households (95.1%) answered the questionnaire. Losses and refusals were more prevalent for males and downtown's sectors. The questionnaire reproducibility was satisfactory (mean kappa = 0.80).CONCLUSIONS: The main methodological aspects of a multidisciplinary research consortium were pointed out, which may be of interest to other researchers. We highlight the importance of these type of study to yield information on various health conditions of the population.
Recém-nascido com deficiência de glicerol quinase: um caso clínico
Authors: Madureira Cristina Duarte P. V. G. , Teles-Silva Cláudia , Melo Cláudia , Gama de Sousa Susana
Published: September 2018

AIMS: To report the case of a newborn with glycerol kinase deficiency, in which an isolated mutation not yet described in the GK gene was identified.CASE DESCRIPTION: A neonate with 10 days of age was brought to the emergency department for refusal to feed with 24 hours of evolution. Physical examination showed a loss of 31% of birth weight and signs of dehydration. Laboratory tests revealed a metabolic acidosis with increased anion gap, creatinine 2.41 mg/dL, urea 306 mg/dL, hypernatremia (182 mEq/L), hyperkalemia (6.8 mEq/L), hyperchloremia (151 mEq/L), glutamic-oxalacetic transaminase 879 U/L, glutamic-pyruvic transaminase 243 U/L, triglycerides 725 mg/dL. Chromotagraphy of organic acids revealed hyperglycerolemia and glyceroluria compatible with glycerol kinase deficiency. The genetic study revealed a mutation not yet described: c.187T> C (p.S63P) as hemizygote status in the GK gene.CONCLUSIONS: The most frequent cause of hypernatremic dehydration in the neonatal period is maternal hypogalactia. In more severe cases of dehydration, other etiologies should be considered, including metabolic causes such as glycerol kinase deficiency. In this case a mutation not yet described in the GK gene was found.