bluuebunny/crossref_metadata_2025 huggingface dataset:
AUTOMATED CHARACTERIZATION OF CARDIOVASCULAR DISEASES USING WAVELET TRANSFORM FEATURES EXTRACTED FROM ECG SIGNALS
Authors: MOHSIN AHMAD , FAUST OLIVER
Published: February 2019

Cardiovascular disease has been the leading cause of death worldwide. Electrocardiogram (ECG)-based heart disease diagnosis is simple, fast, cost effective and non-invasive. However, interpreting ECG waveforms can be taxing for a clinician who has to deal with hundreds of patients during a day. We propose computing machinery to reduce the workload of clinicians and to streamline the clinical work processes. Replacing human labor with machine work can lead to cost savings. Furthermore, it is possible to improve the diagnosis quality by reducing inter- and intra-observer variability. To support that claim, we created a computer program that recognizes normal, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM) or Myocardial Infarction (MI) ECG signals. The computer program combined Discrete Wavelet Transform (DWT) based feature extraction and K-Nearest Neighbor (K-NN) classification for discriminating the signal classes. The system was verified with tenfold cross validation based on labeled data from the PTB diagnostic ECG database. During the validation, we adjusted the number of neighbors [Formula: see text] for the machine learning algorithm. For [Formula: see text], training set has an accuracy and cross validation of 98.33% and 95%, respectively. However, when [Formula: see text], it showed constant for training set but dropped drastically to 80% for cross-validation. Hence, training set [Formula: see text] prevails. Furthermore, a confusion matrix proved that normal data was identified with 96.7% accuracy, 99.6% sensitivity and 99.4% specificity. This means an error of 3.3% will occur. For every 30 normal signals, the classifier will mislabel only 1 of the them as HCM. With these results, we are confident that the proposed system can improve the speed and accuracy with which normal and diseased subjects are identified. Diseased subjects can be treated earlier which improves their probability of survival.
Raman spectra of rare earth double-decker complexes with porphyrinato and 2,3-naphthalocyaninato ligands
Authors: Chen Xin , Wang Chiming , Qi Dongdong , Jiang Jianzhuang
Published: February 2019

The Raman spectra of the mixed (naphthalocyaninato)[tetrakis(4-[Formula: see text]-butylphenyl)porphyrinato] rare earth double-decker compounds M(Nc)(TBPP) (M = Y, La, Ce, Eu, Dy, Lu) were studied with Density Functional Theory for the first time. The results reveal the fingerprint band for naphthalocyanine to be around 1455–1615 cm[Formula: see text] and porphyrin around 693–749 cm[Formula: see text]. Coupled Nc–Por ring–ring interaction vibration modes are also detected at 1470–1522 cm[Formula: see text], owing to the stretching between the central metal and the N atoms. These vibration modes are recognized as the dominating components in the Raman spectra of those double-decker compounds.
Ionic self-assembly of metalloporphyrin/heteropolyacid on multi-wall carbon nanotubes with enhanced electrocatalytic activity toward oxygen reduction reaction
Authors: Han Hongsa , Cao Ziwei , Zhang Yunlong , Qin Jiaqi , Song Yujiang
Published: February 2019

We report the synthesis of a series of hybrid electrocatalysts toward oxygen reduction reaction (ORR) by ionic self-assembly of positively charged Fe(III) meso-tetra([Formula: see text]-methyl-4-pyridyl)porphyrin (FeP) with negatively charged H3PMo[Formula: see text]O[Formula: see text] (PMo[Formula: see text] in ethanol solution under ambient conditions in the presence of suspended multi-wall carbon nanotubes (MWCNTs). Self-assembled FeP/PMo[Formula: see text] was well-dispersed on MWCNTs with a tunable loading from 26.3% to 55.6%. Interestingly, the hybrid electrocatalysts demonstrated a much higher ORR activity than individual PMo[Formula: see text] and FeP in acidic media. We speculate that this activity enhancement might originate from a possible synergy between PMo[Formula: see text] and FeP. This study may be extended to the design and synthesis of other types of hybrid electrocatalysts for applications in electrochemical energy conversion, storage and sensing.
DISCOSPONDYLITIS IN A 7-MONTH-OLD FRENCH BULLDOG: A CASE REPORT
Authors: Chen Chung-Chao , Yang Shu-Fang , Lee Shei-Wen , Yang Heng-Leng , Hsieh Feng-Yi , Hu Kwo-Chen , Liang Sao-Ling
Published: February 2019

A 7-month-old, intact, male French bulldog presented for paraplegia for two days, and persistent fever and diarrhea for seven days. Complete blood count and biochemical profiles were within normal limits. Radiography and computed tomography (CT) revealed destructive endplate lesions between T11 and T12. Surgery of intervertebral disc (IVD) curettage was performed because the dog was beginning to lose deep pain perception. Staphylococcus epidermis was isolated from blood culture and specimens of the IVD. After surgery, intravenous and oral antibiotics were continued for three weeks. The dog regained ambulatory status one month after surgery. Diagnosis of discospondylitis of T11 and T12 was confirmed according to CT and positive bacteria culture. To our knowledge, this case is the youngest dog confirmed with discospondylitis managed successfully, and the first case report of discospondylitis in a French bulldog. Aggressive surgical treatment is highly recommended in young dogs with rapidly progressive neurologic deficits from discospondylitis.
Effects of Nanoscale Structures on Photothermal Heating Behaviors of Surface-Modified Fe3O4 Nanoparticles
Authors: Sadat M. E. , Mast David B. , Sookoor Jason , Xu Hong , Dunn Andrew W. , Shi Donglu
Published: February 2019

In this investigation, the photothermal heating of superparamagnetic Fe3O4 nanoparticles was carried out by irradiating with either 785[Formula: see text]nm or 808[Formula: see text]nm near infrared (NIR) lasers. The effects of nanoparticle configuration, arrangement, and surface coating on the photothermal heating behavior were investigated for different Fe3O4 nanoparticle systems. Depending on the preparation method, Fe3O4 nanoparticles with mean hydrodynamic diameter ranging from 30[Formula: see text]nm to 250[Formula: see text]nm were synthesized. Photothermal transduction efficiency is a measure of light to thermal energy conversion; the highest efficiency obtained was 56% by 785[Formula: see text]nm and 42% by 808[Formula: see text]nm light irradiation for poly(acrylic) acid (PAA) coated Fe3O4 samples. With this conversion efficiency, the PAA-coated Fe3O4 nanoparticles raised the solution temperature [Formula: see text] [Formula: see text]C above physiological temperature, which is sufficient for cancer therapeutics. Photothermal transduction efficiency was found to decrease as the particle hydrodynamic diameter increased. Nanoparticle absorption and scattering properties were found different due to surface modifications. UV-VIS-NIR absorption spectroscopy was carried out and results were analyzed using the Mie scattering theory. Experimental photothermal transduction efficiency was found to scale with the theoretical results for a particular wavelength. These results have significance in the design and development of the Fe3O4 nanoparticle systems for effective cancer therapy with NIR light.
The Interest Rate Effect on Private Saving: Alternative Perspectives
Authors: Aizenman Joshua , Cheung Yin-Wong , Ito Hiro
Published: February 2019

Lowering the policy interest rate could stimulate consumption and investment while discouraging people from saving. However, such a move may also prompt people to save more to compensate for the low rate of return. Using the data of 135 countries from 1995 to 2014, we show that a low interest rate environment can yield different effects on private saving under different economic environments. The real interest rate affects private saving negatively if output volatility, old-age dependency, or financial development is above a certain threshold. Depending on a country’s specific economic circumstances, these effects are significant for the economy — a four-percentage point decline in the real interest rate, which is approximately the same as one standard deviation for China, would lead to a 1.52 percentage point increase in the Chinese private saving rate. Further, when the real interest rate is below 1.1%, greater output volatility would lead to higher private saving in developing countries.
Structure, electrical properties and temperature stability of PIN–PZN–PT piezoelectric ceramics with morphotropic phase boundary compositions
Authors: Wang Tingting , Yang Longhai , Song Kexin , Li Zhenrong , Xu Zhuo
Published: February 2019

A series of Pb(In[Formula: see text]Nb[Formula: see text]O3–Pb(Zn[Formula: see text]Nb[Formula: see text]O3–PbTiO3 (PIN–PZN–PT) ternary piezoelectric ceramics with compositions at the morphotropic phase boundary (MPB) were prepared. The phase structure, microstructure, electrical properties and temperature stability of PIN–PZN–PT ceramics were investigated systematically. The structural analysis indicated that an MPB phase consisting of rhombohedral and tetragonal phases was formed in all ceramics. For the selected compositions, dielectric measurements demonstrated that the Curie temperature [Formula: see text] changed from 237∘C to 295∘C and showed a strong trend of compositional dependence. All the samples showed good piezoelectic properties. Particularly, the 0.35PIN–0.40PZN–0.25PT sample has the optimum piezoelectric properties, the piezoelectric coefficient [Formula: see text] is 589 pC/N, the electromechanical coupling factors [Formula: see text] and [Formula: see text] are 59% and 49%, respectively. Compared with PZN–PT and PMN–PT ferroelectric crystals, the superior limit of usage temperature of PIN–PZN–PT ceramics was achieved around 230∘C by thermal depoling method. These results make PIN–PZN–PT ceramics a promising material to meet the practical demands of higher temperature and larger electric field operating ranges.
Thermal-aware Test Scheduling Strategy for Network-on-Chip based Systems
Authors: Manna Kanchan , Sagar Chatla Swami , Chattopadhyay Santanu , Sengupta Indranil
Published: February 2019

Rapid progress in technology scaling has introduced massive parallel computing systems with multiple cores on the integrated circuit (IC), in which a flexible and scalable packet-switched architecture, Network-on-Chip (NoC), is commonly used for communication among the cores. However, technology scaling has also increased the susceptibility to internal defects in such systems. So, manufacturing tests of such multicore systems is crucial and this is a complex and time-consuming process. Due to stress on time-to-market, test engineers focus on the reduction of testtime and perform parallel tests of cores. Due to aggressive technology scaling into the nanometer regime, power consumption is also becoming a significant burden. Moreover, power consumption during manufacturing tests is more as compared to normal operation. In addition, peak power consumption is often significantly higher than the average power values. The consumed power leads to high temperature and creates hotspots, which in turn leads to failure of good parts, resulting in yield loss. Thermal safety during testing is an utmost challenging problem in NoC-based multicore systems, including three-dimensional NoC-based (3D NoC) multicore systems due to stacking of layers. This work proposes a preemptive test scheduling technique for NoC-based multicore systems to reduce the testtime by minimizing conflicts of resource usage. The preemptive test scheduling problem has been formulated using Integer Linear Programming (ILP). In this article, authors have also presented a thermal-aware test scheduling technique to test cores in 2D as well as 3D stacked NoC-based multicore systems using a Particle Swarm Optimization (PSO) based approach. To improve the solution further, several innovative augmentation techniques have been incorporated in the basic PSO. Experimental results highlight the effectiveness of the proposed method in reducing testtime and peak temperature under the power constraints and achieve a tradeoff between testtime and peak temperature.
Variety Is the Spice of Life, but Maybe Not in Gastroesophageal Adenocarcinomas
Authors: Klempner Samuel J. , Catenacci Daniel V.T.
Published: February 2019

Sanchez-Vega and colleagues prospectively demonstrate that both intra- and intertumoral differential expression of the receptor tyrosine kinases HER2, EGFR, and MET dictate sensitivity to the pan-HER inhibitor afatinib in a phase II trial of trastuzumab-refractory HER2-amplified gastroesophageal adenocarcinomas. Rapid autopsy, tissue-based genomic characterization, and molecular imaging provide complementary information and may aid in selecting optimal patients for targeted monotherapy versus combination approaches in gastroesophageal adenocarcinomas.

See related article by Sanchez-Vega et al., p. 199.
ACT-FASTER, a Prospective Cohort Study Exploring Treatment Patterns with Fulvestrant and Exemestane in Postmenopausal Patients with Advanced Hormone Receptor-Positive Breast Cancer under Real-Life Conditions in Germany
Authors: Maass Nicolai , Ostermann Helmut , Possinger Kurt , Klein Peter , Tesch Hans , Mühlenhoff Lars , Bauerschlag Dirk
Published: February 2019

Background: Endocrine therapy is recommended for the treatment of postmenopausal women with hormone receptor-positive (HR+) advanced breast cancer (ABC). Methods: ACT-FASTER was a German prospective non-interventional cohort study in postmenopausal women with HR+ ABC receiving fulvestrant 500 mg as first line (1 L), second line (2 L) or third line (3 L), or exemestane (any line) in the real-world palliative setting. Primary study objectives included the effectiveness of fulvestrant according to line of palliative treatment measured by time to progression (TTP), and real-life data on the epidemiology and management of these patients. Results: Of 498 evaluable patients (mean age 67.5 years), 99% were estrogen receptor-positive. On study, 86.7% of patients received fulvestrant 500 mg and 13.3% exemestane. Median TTP was 9.7 months in patients receiving fulvestrant 1 L; 6.8 months for 2 L; and 6.7 months for 3 L. The comparison between fulvestrant 1 L palliative treatment and 2 L or 3 L showed that early initiation of treatment prolonged TTP (hazard ratio 1.26; 95% confidence interval 1.08-1.48). Treatments were well tolerated. Conclusion: Fulvestrant 500 mg was administered successfully to patients under daily practice conditions, and both medications were well tolerated. TTP was longest in patients treated with fulvestrant 500 mg 1 L compared with 2 L and 3 L in the palliative care setting.
A Familial Case of a Whole Germline CDC73 Deletion Discordant for Primary Hyperparathyroidism
Authors: Hatabu Naomi , Katori Naho , Sato Takeshi , Maeda Naonori , Suzuki Eri , Komiyama Osamu , Tsutsui Hidemitsu , Nagao Toshitaka , Nakauchi-Takahashi Hana , Matsunaga Tatsuo , Ishii Tomohiro , Hasegawa Tomonobu , Yamazawa Kazuki
Published: February 2019

Introduction: Primary hyperparathyroidism (PHPT) occurs as part of familial syndromes, including CDC73-related disorders caused by germline pathogenic variants of the CDC73 gene, particularly in early adulthood. Herein, we report a familial case of a whole germline CDC73 deletion discordant for PHPT. Case Description: A 15-year-old boy was admitted to our hospital because of persistent nausea and vomiting. Laboratory tests showed hypercalcemia (13.6 mg/dL), hypophosphatemia (2.4 mg/dL), and elevated intact PTH level (149 pg/mL). Imaging studies showed an enlarged single parathyroid gland. Thus, the diagnosis of PHPT was made. Microarray analysis of peripheral blood DNA showed a 3.4-Mb heterozygous deletion of 1q31 encompassing 11 genes, including CDC73. Total thyroidectomy/parathyroidectomy was performed; histology was compatible with parathyroid adenoma without any evidence of malignancy. DNA sequencing of the removed adenoma confirmed a hemizygous nonsense variant in the CDC73 gene in a mosaic manner, which was potentially involved in parathyroid tumorigenesis as the “second hit.” Importantly, the same deletion was identified in his 52-year-old father who had an unremarkable medical history. Conclusions: These data clearly demonstrate the Knudson two-hit theory from a molecular viewpoint. Phenotypic variability and incomplete penetrance of CDC73-related disorders, even if caused by a gross deletion, should be noted in a clinical setting.
Behaviors and Strategies Supporting Everyday Memory in Older Adults
Authors: Hertzog Christopher , Lustig Emily , Pearman Ann , Waris Aiman
Published: February 2019

Background: Little is known about the means by which older adults achieve memory-demanding goals in everyday life or alternatively about why they fail to do so. Objectives: We conducted qualitative interviews to evaluate what older people do to support everyday memory functioning. A principal focus was on understanding the ways in which individuals use internal memory strategies and external memory aids. Methods: We interviewed 25 community-dwelling older adults (mean age 70 years) in a semi-structured interview. The transcribed results were coded by extracting segments of the interviews and classifying the responses into emergent categories. All coded interview segments were reviewed by category. Memos were created and relevant themes identified. Results: The older adults reported everyday memory failures (such as forgetting names), often without nominating explicit methods for avoiding these problems. They also reported using a number of external memory aids such as calendars and lists. Our interviews indicated this use was typically a part of complex routines and habits of living that often seemed vulnerable to errors. For instance, people would report filling medication organizers or completing to-do lists without mentioning plans for how to effectively use these aids later. Furthermore, they often reported reliance on spontaneous encoding and retrieval – for example, stating that they would routinely remember to perform important actions in the future. Conclusions: Older adults’ reported everyday memory failures were linked to suboptimal use of external memory aids and to a reliance on incidental learning and remembering. There is potential value for interventions that improve procedures for managing everyday life goals that rely on memory.
Highly Aggressive and Radiation-Resistant, “Atypical” and Silent Pituitary Corticotrophic Carcinoma: A Case Report and Review of the Literature
Authors: Flores Laura , Sleightholm Richard , Neilsen Beth , Baine Michael , Drincic Andjela , Thorell William , Shonka Nicole , Oupicky David , Zhang Chi
Published: February 2019

Background: Pituitary tumors typically remain silent unless interaction with nearby structures occurs. Rare subsets of pituitary tumors display aggressive phenotypes: highly mitotic, locally invasive, metastatic, chemotherapy and radiation resistant, etc. Disease progression and response to therapy is ill-defined in these subtypes, and their true prognostic potential is debated. Thus, identifying tumor characteristics with prognostic value and efficacious treatment options remains a challenge in aggressive pituitary tumors. Case Presentation: A 45-year-old female presented with a nonfunctioning corticotropic pituitary macroadenoma with biomarkers suggestive of an “atypical” subtype: Ki-67 of 8–12%, increased mitosis, and locally invasive. Despite resections and radiation, growth continued, eventually affecting her vision. Although histologically ACTH positive, the patient remained clinically asymptomatic. Twelve months later, an episode of Cushing’s disease-induced psychosis prompted a PET-CT scan, identifying sites of metastasis. Temozolomide was added to her medical regimen, and her metastatic liver lesions and boney metastases were treated with radiofrequency ablation and stereotactic body radiation therapy, respectively. Systemic treatment resulted in a drop in her ACTH levels, with her most recent scans/labs at 12 months following RFA suggesting remission. Conclusions: This is a unique presentation of a pituitary tumor, displaying characteristics of both clinically silent corticotropic and “atypical” macroadenoma subtypes. Although initially ACTH positive while clinically silent, the patient’s disease ultimately recurred metastatically with manifestations of Cushing’s disease and psychosis. With the addition of temozolomide to her treatment plan, her primary and metastatic sites have responded favorably to radiation therapy. Thus, the addition of temozolomide may be beneficial in the treatment of aggressive pituitary tumors.
Acute Ischemic Stroke in Late Pregnancy Treated with Intravenous Thrombolysis and Endovascular Therapy
Authors: Szuchy Kristiansen Eva , Holm Vestergaard Hannah , Modrau Boris , Oppel Lorenz Martin
Published: February 2019

Pregnancy has usually been an exclusion criterion in clinical trials with thrombolysis and endovascular therapy in acute ischemic stroke. For that reason, these therapies are not recommended causing lack of evidence and vice versa. In this case report, we describe a pregnant woman in week 33 + 3 presenting with acute ischemic stroke, which was successfully treated with systemic thrombolysis and endovascular therapy, resulting in a good clinical outcome for both mother and child. The altered fibrinolytic system and the risk factors related to pregnancy constitute a challenge for clinicians when choosing the most suitable treatment modality for treating acute ischemic stroke in pregnancy. It is still uncertain whether thrombolysis in combination with endovascular therapy or endovascular therapy alone is the most appropriate treatment option. However, there is slowly growing evidence that thrombolysis and thrombectomy in pregnancy are feasible and safe with a good clinical outcome for both the mother and the child.
INVENTORY OF THE INVASIVE ALIEN PLANT SPECIES IN INDONESIA
Authors: TJITROSOEDIRDJO SRI SUDARMIYATI
Published: February 2019

An inventory of the alien plant species in Indonesia based on the existing references and herbarium specimens concluded that 1936 alien plant species are found in Indonesia which belong to 187 families. Field studies should be done to get the complete figures of alien plant species in Indonesia. Based on the existing figures of the plant species, the invasive alien plant species can be identified, followed by studies on the assessment of losses, biology, management and their possible utilizations. Alien plant species are imported to Indonesia for cultivation, collection of the botanical garden, as experimental plants or other curiosities. Aside from plants purposely imported, there are also introduced plant propagules contaminating imported agricultural products. These alien plant species can be beneficial or have a potential of being invasive. The alien cultivated species consisted of 67% of the total number. More than half of the cultivated plants are ornamental plants. Some of the species are naturalized or escaped from cultivation and become wild and invasive. Some other naturalized species, adapted well without any problems of invasion. There are 339 species or 17% of the species recorded as weeds. The highest record of weeds is found in the family of Poaceae (57 species), followed by Asteraceae (53 species) and Cyperaceae (35 species). There are 6 families having more than 10 species of weeds: Amaranthaceae, Asteraceae, Cyperaceae, Euphorbiaceae, Poaceae, and Rubiaceae. Three families have more than 100 species: Asteraceae 162 species, Poaceae 120 species, and Papillionaceae 103 species. Five species of aquatic and 20 species of terrestrial plants considered as important alien plant species in Indonesia were identified and some of their distributions noted. Keywords: Alien plant species/Invasive alien plants/Weeds/Environmental weeds/Aquatic and terrestrial alien plants
CHROMOSOMES OF THE PHILLIPINE SNAKE-HEAD GUDGEON, OPHIELEOTRIS APOROS (ELEOTRIDAE) FROM LAKE TAAL, LUZ ON ISLAND.
Authors: Masagca Jimmy T. , Ordonez Jose A.
Published: February 2019

Metaphase chromosomes analyzed from the anterior kidneys of Ophieleotris aporos obtained from Lake Taal in Luzon Island, Philippines revealed that the diploid chromosome number was 2n=46. The fundamental number (FN) is 48 (2 submetacentric and 44 acrocentric chromosmes) was known. There was no distinguishable hetemorphic pair of chromosomes in the Giemsa-banded metaphase spreads. This is an initial report on the chromosome set of O. aporos in the this country.
ASPERGILLUS FLAVUS INFECTION AND AFLATOXIN CONTAMINATION IN PEANUTS AT VARIOUS STAGES OF THE DELIVERY CHAINS IN WONOGIRI REGENCY, CENTRAL JAVA, INDONESIA
Authors: Dharmaputra Okky Setyawati , Retnowati Ina , Ambarwati Santi
Published: February 2019

As a part of an Australian Centre for International Agricultural Research (ACIAR) project on management of aflatoxin in Indonesia and Australia (PHT 97/017), a survey on pre- and postharvest handling of peanuts at farmer, collector retailer levels, including Aspergillus flavus Â infection and aflatoxin B1 contamination of peanuts collected in Wonogiri regency, Central Java, was conducted during the harvest period of the wet (February 2003) and dry (June 2003) seasons. Interviews using questionnaires, with farmers, collectors and retailers concerning pre- and post-harvest handling of peanuts were carried out. The moisture contents and physical quality of the peanut kernels were also determined. During the wet and dry seasons, fresh pod samples were collected from farmer fields (24 samples), dry raw pod samples from collector (24 samples) and raw kernel samples from retailer levels (54 samples). Thus, during each season 102 samples of various kinds of peanuts were collected for analysis. The A. flavus infection in kernel samples of peanuts collected from retailers were the highest, followed by samples collected from collectors and farmers. The A. flavus infection in kernel samples collected during the dry season was in general lower than in the wet season. It was alarming to note that all most all samples of raw kernel samples collected from retailers were infected by A. flavus during the wet and dry seasons. In general aflatoxin B1 levels in peanut samples collected in the wet season were higher than the dry season. During the wet and dry seasons, the aflatoxin B1 contents in retailer samples were the highest, followed by those collected from collectors and farmers. During the wet season, around 4, 17 and 33% of peanut samples collected from farmers, collectors and retailers, were respectively contaminated with more than 15 ppb of aflatoxin B1. During the dry season, around 42 and 74% of peanut samples collected from collectors and retailers, were respectively contaminated with more than 15 ppb of aflatoxin B1, while aflatoxin levels in wet raw pod samples collected from farmers were less than 15 ppb. In 2003 Codex Alimentarius Commission has determined a maximum level of total aflatoxins in peanuts intended for further processing at 15 ppb.
THE PRESERVATION OF MILK WITH THE ADDITION OF ANTIBACTERIAL AND AROMATIC SUPPLEMENTS PRODUCED IN INDONESIA
Authors: Khusniati Tatik , Widyastuti Yantyati
Published: February 2019

The preservation of milk with additional antibacterial and aromatic supplements, produced in Indonesia, was investigated. Organoleptic performances of milk with the addition of 10% supplements, made as juices, were tested by panellists, and the total bacteria, protease activities, lipase activities and acidities, were detected by total plate counts, azocasein method, modified dole extraction and base-acid titration, respectively. Out of the 27 supplemented skim and whole milk samples, 15 whole milk samples and 10 skim milk samples were selected as acceptable, based on their better organoleptic performances, their lower bacterial counts, protease and lipase activiÂ­ties, and their acidities percentages which were not significantly different, compared to that of control, at 5 days after the expiry date (P
OCCURRENCE AND DISTRIBUTIONAL RANGE OF MANGROVE VASCULAR FLORA OF CATANDUANES ISLAND, LUZON, PHILIPPINES
Authors: MASAGCA JIMMY TEVAR
Published: February 2019

Mangroves play very significant roles not only on the economic aspects but also on the ecological aspects as biobelting for tidal surges and tsunamis. The loss of human lives due to the deadly tsunamis in East Asia and the unabated destruction of coastal vegetation have resulted in a renewed focus on the mangrove resources. The purpose of this paper is to report the existing mangrove database of the typhoon-prone island province of Catanduanes in Luzon, Philippines which will be used as bases in determining the appropriate educational management initiatives of various sectors for mangrove rehabilitation and regeneration.Â Â  A total of 37 species of mangrove vascular flora (13 species of major mangrove elements, 10 species of minor mangrove elements and 14 associated mangrove species) were identified in the island under study. Two species of the genus Avicennia (A. marina and A. officinalis) were noted in the island. The other genera (Bruguiera, Ceriops, Sonneratia and Rhizophora) are well distributed in the designated eco-zones. Nypa fruticans is the most important mangrove plant species and a member of the screwpine family (Pandanaceae), Pandanus tectorius which is an associated mangrove species is well-distributed all throughout the island.Key words:Â  Mangroves, vascular flora, Catanduanes, Philippines, occurrence and distribution.
PHYSIC NUT (JATROPHA CURCAS L.) DISEASES IN LAMPUNG PROVINCE
Authors: GINTING CIPTA
Published: February 2019

Intensified cultivation of physic nut (Jatropha curcas L.) could raise the importance of plant diseases.Â  The objectives of this research were to diagnose diseases occurring on physic nut in Lampung Province and to determine their intensity.Â  Field observation was conducted in four districts: South Lampung, Tanggamus, Bandarlampung, and Tulang Bawang.Â  Disease intensity, whether expressed as disease incidence or severity, was recorded from plant samples determined by making diagonal lines across the field on which five observation spots were made.Â  On each spot, five plant samples were observed.Â  Specimens were also collected and placed individually in plastic bags for laboratory observation.Â  The diseases found on physic nut in Lampung Province were cercospora leaf spot, alternaria leaf spot, fusarium wilt, and bacterial wilt.Â  In addition, leaf malformation first thought to be viral disease was commonly found in many locations.Â  Further mechanical transmission failed to produce similar symptom on tested plants and higher population of mites were found on malformed leaves than that in normal leaves.Â  Based on the disease distribution and intensity, the most likely threatening disease in physic nut cultivation is bacterial wilt.Â  Fusarium alsoÂ  caused wilt, but it was only found in one subdistrict with low incidence.Â  Keywords: Alternaria, Cercospora, fusarium wilt, bacterial wilt, Jatropha curcas diseases
LIPID PRODUCING MICROALGAE FROM SEVERAL ECOSYSTEMS IN WEST AND CENTRAL JAVA, INDONESIA
Authors: SANTOSA DWI ANDREAS , SULASTRI
Published: February 2019

This study is aimed to get lipid producing microalgae as feedstock for biofuel production. The microalgae were isolated from 355 collected water samples which Â represented many distinct ecosystems such as paddy fields, rivers, agricultural dams, ponds, swampy areas and unique ecosystem of volcano and mud-volcano craters in West- and Central Java, Indonesia. A total of Â 267 strains of microalgae were isolated from the samples of which Â 221 strains of them have capability to produce lipid. There were four promising strains that produce lipid between 14.7 â€“ 45.7 percent dry weight in optimal condition that were identified as Chlamydomonas sp. KO-7267 and PK-7195, Chlorella sp. KS-7300 and Desmodesmus sp. BK-7291.
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Keywords: microalgae, lipid, biofuel, Indonesian ecosystems
DIETARY EXPOSURE ASSESSMENT FOR AFLATOXIN B FROM PROCESSED PEANUT PRODUCTS IN MUNICIPALITY OF BOGOR 1
Authors: SETYAWATI DHARMAPUTRA OKKY , SANTI SANTI AMBARWATI , INA INA RETNOWATI
Published: February 2019

A research on dietary exposure assessment for aflatoxin B (AFB1) fromprocessed peanutproducts in Municipality of Bogor was carried out. The objectives of this study were todetermine the contents of AFB1 in processed peanut products at retail levels, and to obtaininformation whether there is a risk to public health caused by the consumption of processedpeanut products contaminated by AFB1. Survey of processed peanut product consumptionwas carried out by interviewing each respondent using a questionnaire of weekly processedpeanut product consumption. Sampling of processed peanut products was conducted at thelocations where the respondents obtained processed peanut products. The number of roastedpeanuts with skin pods, flour-coated peanuts and or sauces samples was 33,respectively, while the number of and sauces samples was 18 and 12, respectively.The total number of processed peanut product sampleswas 129.AFB1contentwas determinedusingThin LayerChromatographymethod.Estimation of the dietary exposure assessmentwasdetermined using the actual survey data consisting of AFB1 content, consumption data andbody weight. The highest contaminated sample percentage and mean of AFB1 content wasfound in roasted peanuts with skin pods i.e. 42% of 33 samples and 43.2 Î¼g/kg, respectively,followed by flour-coated peanuts (30% of 33 samples and 34.3 Î¼g/kg), and or(21%of 33 samples and 17.1 Î¼g/kg).Mean of estimated dietary exposure for AFB1 found inchildren was 15.2 ng kg bw day and 95 percentile exposure was 38.9 ng kg bw day , while inadults 9.0 ng kg bw day and 95 percentile exposure was 27.0 ng kg bw day . The excesscancer risk of AFB1 exposure in Bogor fromthis study on children and adults was calculated as193 and 115 cancers/year, respectively-1 -1 th -1 -1-1 -1 th -1 -1pecel gado-gadosiomay sataipecel gado-gado1.
DENGUE EARLY WARNING MODEL USING CLIMATE INFORMATION
Authors: Hidayati Rini -
Published: February 2019

The use of early warning system is potential adaptation options to reduce the impact of the climate variability and change.Â  This study aims to develop a dengue early warning model using climate information.Â  The model was developed through three steps of analysis.Â  First step was to determine the length of periods used in prediction and optimal time for eradicating Aedes aegypti mosquitoâ€™s breeding sites.Â  Second step was to identify the best prediction model of dengue incidence rate (IR).Â  Third step was to develop an early warning model using stochastic spreadsheet.Â Â  It was found that the best predictors for predicting dengue incidence rate at week-n (IRn) were (1) rainfall index with two weeks lead time (ICHn-2).Â  The rainfall index of week-nth is a function of three week moving averages rainfall (CH3), i.e. (CH3n-1.155*CH3n-1+0.702*CHn-2), and (2) IR with one week lead time (IRn-1).Â  The IR model prediction was IRn = 0.795*IRn-1+0.067*ICHn-2 with R2=76.6%.Â  These models (result model from first and third step) can be used to provide early warning on optimum time for controlling the mosquitoâ€™s breeding sites and the need for fogging action in order to avoid the dengue incidence rate beyond the critical limit defined by the Ministry of Health
Plant community and soil relationship following wildfires from nuees ardentes on Mt. Merapi
Authors: Sutomo Sutomo , Fardila Dini
Published: February 2019

At a local scale, vegetation patterns are known to have strong relationships with edaphic factors. In the case of Mt. Merapi volcanic eruption, studies on the relationships between edaphic factors and plant community composition and distribution following the nuees ardentes-ignited wildfires will provide valuable information on post-disturbance secondary successional processes. We collected soil and vegetation data from five different ages of nuees ardentes fire-affected secondary succession forests and one un-affected forest. Our results showed significant correlation of species composition and edaphic factors among sites of secondary forests. Nitrogen and soil water content were found to be the important factors in structuring species composition in the youngest site, where the N-fixing legume species such as Calliandra callothyrsus was found to be dominant. CCA ordination also revealed strong negative correlation between nitrogen content and legume group, while non-legume group were positively correlated with other edaphic factors such as phosphor and potassium. These findings suggested that changes in soil properties due to recovery of this system after volcanic eruption correlated with plant community composition and can be crucial factors in driving the successional trajectory. Understanding ecosystem reassembly process and trajectory of succession will improve how we approach the restoration of Mt. Merapi ecosystem.
MOLECULAR IDENTIFICATION AND PHYLOGENETIC RELATIONSHIP AMONG LOCAL, SANGKURIANG, AND AFRICAN CATFISH BASED ON RAPD MARKER
Authors: Nuryanto Agus
Published: February 2019

Catfish species are commercially cultivated freshwater fish by fish farmer. Formerly, only one species of catfish had been cultivated, namely local catfish (walking catfish) Clarias batrachus.Â  However, since 1985, local catfish was replaced by a new commodity from Africa called African catfish (C. gariepinus).Â  In 2004, BBPBAT Sukabumi had introduced a new strain of catfish, namely Sangkuriang catfish.Â  Taxonomic analysis needed, especially for Sangkuriang catfish using molecular marker, in order to get a clearer picture about its genetics departure from their parental, so their taxonomic status and relationships with local and African catfish is clearer. Â One of the molecular markers is randomly amplified polymorphic DNA (RAPD) markers. Species status defined based on the presence and absence of specific band on each catfish.Â  Phylogenetics relationships was inferred from phylogenetic tree which was built using UPGMA tool as implemented in NTSYS software based on the similarity of RAPD band pattern. The result showed that Sangkuriang and local catfish had specific RAPD markers, while African catfish was not. This means that all RAPD markers of African catfish were shared with those of two others catfish. Local catfish phylogenetically distantly related to African and Sakuriang catfish. Only one individual of African catfish (D4) genetically close related to Sangkuriang catfish while the rest individuals of African catfish genetically closed related to green catfish. This means that African catfish showed very divergence genetic constituent.Â  Â  Key words: catfish, molecular identification, phylogenetic relationships, RAPD
POSTHARVEST QUALITY IMPROVEMENT OF SORGHUM (Sorghum bicolor (L.) Moench) GRAINS
Authors: DHARMAPUTRA OKKY SETYAWATI
Published: February 2019

The objectives of this study were (a) to investigate the effect of postharvest handling (threshing and storage) methods on the quality of sorghum (Sorghum bicolor (L) Moench) grains variety Numbu, in terms of the percentages of damaged grains and seed germination, population growth of S. zeamais, F. proliferatum and F. verticillioides; fumonisin B1 and carbohydrate contents, and the percentage of weight loss during storage. The change of moisture contents of sorghum grains was also recorded. Threshing was conducted using a stick of wood and a paddy thresher. Sorghum grains were packed in hermetic plastic bags. The conditions inside of the bags wereÂ  airtight and normal conditions. Each bag with different conditions inside of the bag was introduced with 10 pairs of Sitophilus zeamais (1-14 days old). Sorghum was stored for one, two and three months of storage under warehouse conditions. The results showed, that during storage the moisture contents of sorghum wereÂ  lower than that its standard safe moisture content (
Síndrome de Burnout
Authors: Souza Lucas Ramon Santos de , Souza Erivaldo Lopes de , Barroso Barbara Iansã de Lima
Published: February 2019

O presente estudo teve como objetivo investigar as dimensões da síndrome de burnout em acadêmicos do Curso de Terapia Ocupacional de uma universidade federal do nordeste brasileiro. Tratou-se de um estudo exploratório, com elementos descritivos transversais e correlacionais quantitativos, realizado com 147 estudantes do primeiro ao oitavo período do curso. Para a coleta dos dados, aplicaram-se o instrumento Maslach Burnout Inventory – Student Survey (MBI-SS) e um questionário sociodemográfico elaborado pelos autores, e para o tratamento estatístico dos dados, os programas Excel 2007 e o SPSS. Procedeu-se a uma análise fatorial exploratória, para obter os escores das dimensões da síndrome para posterior comparação entre os períodos. Os resultados obtidos indicaram os maiores escores nas dimensões ‘eficácia profissional’ e ‘descrença’ no 4º período do curso. A ‘eficácia profissional’ apresentou um alto valor mediano dos escores nos anos finais do curso, o que indica que esses alunos tendem a se sentir competentes como acadêmicos. Embora os resultados não apontem a presença da síndrome de burnout, discute-se a transformação do Projeto Pedagógico do Curso, visando melhorar a qualidade de vida dos acadêmicos e divulgar a profissão/curso entre os profissionais da saúde e na comunidade.
Fatores associados à evasão de discentes de um curso de Terapia Ocupacional
Authors: Silva Brunna Emannuelly Nóbrega da , Bregalda Marília Meyer
Published: February 2019

A evasão estudantil é o desligamento permanente do discente do seu curso de origem antes de concluí-lo e se trata de um fenômeno multifatorial, pois pode estar associada a fatores pessoais e a fatores internos e externos à instituição. Essa pesquisa objetivou identificar e compreender os fatores associados à evasão do curso de Terapia Ocupacional da Universidade Federal da Paraíba. Aplicou-se um questionário semiestruturado com os discentes evadidos que aceitaram participar da pesquisa. Os dados das respostas às questões fechadas forneceram um panorama geral dessa evasão, e as respostas às questões abertas foram sistematizadas em categorias referentes aos posicionamentos dos discentes sobre o fenômeno. Verificou-se a multifatorialidade da evasão do curso, com predominância dos fatores pessoais, sendo a falta de identificação com o curso, o interesse por outra profissão e o desconhecimento sobre o curso os fatores mais apontados, seguidos pelos auxílios estudantis insatisfatórios. Desta forma, deve-se priorizar o investimento no conhecimento da profissão pela sociedade, no acompanhamento vocacional antes e depois do ingresso na universidade e desenvolver ações de luta pela melhoria da estrutura e do funcionamento do curso e da instituição e das condições de assistência e permanência estudantil.
A gramática da história:
Authors: Condé Mauro Lucio Leitão
Published: February 2019

Inspirado nas noções de gramática e pragmática da linguagem de Wittgenstein, a proposta desse artigo é apresentar a ciência da história como uma “gramática”. Talvez o sentido geral da noção de gramática do segundo Wittgenstein pudesse ser expresso da seguinte forma: o que é lógico ou racional está expresso nas regras da gramática de nossos comportamentos sociais. O que é lógico ou não é dito pela gramática. Podemos estender essa concepção de racionalidade gramatical de Wittgenstein para a ciência da história que em seu modus operandi também pode ser entendida como uma gramática. Essa “gramática da história” – como uma caracterização da racionalidade científica que insere sentido aos processos históricos – pode ser concebida como uma “teoria da história” que compreende tais processos históricos como uma “teia”, uma rede flexível e multidirecional de linguagens, práticas e interações sociais que se estende por meio de “semelhanças de família”. Essa rede gramatical não se propõe a fornecer “uma” inteligibilidade total e completa de uma “grande narrativa” do mundo, mas simplesmente proporcionar a compreensão de nossa condição de seres inseridos na gramaticalidade de nossa própria história, ainda que nossa gramática compartilhe “semelhanças de família” com outras gramáticas.
As Balizas de um método de investigação epistemológico, histórico e cultural da ciência.
Authors: Suzuki Márcio
Published: February 2019

O presente artigo discute os métodos de investigação na filosofia e história da ciência quanto a originalidade e o seu alcance heurístico. As duas exposições que serão discutidas aqui têm em comum o fato de aplicarem em ato o que é exposto como desiderato, numa implicação frutífera de objeto e método. Além disso, o que é importante, elas elaboram o que seria o procedimento investigativo em diálogo com os autores dos quais se extraem os elementos estruturantes do método.
Finalmente um lugar para a história da arte no Brasil?
Authors: Amaro1 Danielle Rodrigues
Published: February 2019

Tendo como ponto de partida as controvérsias acerca da criação recente de bacharelados em história da arte em universidades públicas brasileiras, o presente artigo tem como objeto central as disputas institucionais e epistemológicos entre as comunidades científicas de historiadores e de historiadores da arte. A problematização das histórias da arte produzidas nas universidades brasileiras são fundamentais ao debate acerca do que se compreende por história da arte no Brasil hoje e estão diretamente relacionadas ao amadurecimento e à consolidação da autonomia da história da arte enquanto campo científico no país. Para isso, são usadas como fontes: entrevistas; documentos oficiais produzidos pelas duas comunidades científicas em disputa; e documentos relacionados ao trâmite do PL 4699/2012, que regulamenta a profissão de historiador.
WHODAS 2.0-BO
Authors: Ferrer Michele Lacerda Pereira , Perracini Monica Rodrigues , Rebustini Flávio , Buchalla Cassia Maria
Published: February 2019

OBJECTIVE: To examine the normative data of WHODAS 2.0-BO for older Brazilians (World Health Disability Assessment Schedule – Brazilian version for older people) and its distribution according to sex, age, health, subjective health perception, performance in a mobility test and presence of chronic diseases and depression. METHODS: Cross-sectional study, with 350 participants with 60 years of age or older, men and women, patients of a geriatric specialized center for medical consultations or rehabilitation. The older adults were evaluated using a semi-structured questionnaire containing demographic and clinical data (WHODAS 2.0-BO) and the geriatric depression scale (GDS), having been subsequently subjected to a mobility test (Timed Up and Go). The data were analyzed via their distribution in percentiles of the population and via analysis of variance. RESULTS: Two-hundred and sixty-six (76%) participants were women, and the average age was 71.8 (DP = 6.7) years old. The average score in WHODAS 2.0-BO was 4.3 (DP = 5.2) points, the highest value found having corresponded to 33 points. The average time for the Timed Up and Go test was 10.0 (SD = 3.2) seconds. About 30% of the older adults did not report any difficulties in the tasks evaluated by WHODAS 2.0-BO and half of the sample scored up to two points. CONCLUSIONS: A score corresponding to 12 points in the 90 percentile on a scale from zero to 40 was observed, which suggests severe disability. The score in WHODAS 2.0-BO increased with the advance in age, as well as in the presence of comorbidities, negative health perception, depression, high blood pressure, visual and hearing impairment and mobility impairment.