bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis
Authors: Wu Limeng , Jiang Canhua , Zhu Zhihui , Sun Yao , Zhang Tao
Published: July 2022

Background

Although programmed cell death-ligand 1 (PD-L1) has been recognized as a potential marker in several cancers, the relationship between PD-L1 expression and survival in patients with salivary gland carcinoma (SGC) has remained unclear. We aimed to evaluate the association of PD-L1 expression with clinicopathological features and prognosis in SGC patients.

Methods

The databases Ovid Medline, PubMed, Scopus, and EMBASE were searched for relevant studies that detected PD-L1 expression in SGC. The meta-analysis was performed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA), and the reporting recommendations for tumor marker prognostic studies (REMARK) was used to assess the quality of research eligible for this meta-analysis. Included studies were assessed using the Quality in Prognosis Studies (QUIPS) tool. Odds ratios (ORs) with 95% confidence interval (CI) were calculated to estimate the correlation between PD-L1 expression and clinicopathological features. Hazard ratios (HRs) with 95% CI were applied to assess the association between PD-L1 expression and survival outcomes of patients.

Results

A total of ten studies (including 952 patients with SGC) were evaluated. The meta-analysis showed that positive PD-L1 expression in SGC was significantly associated with male patients, older age, Tumor stage, lymph node metastasis, high pathological grade, and non-adenoid cystic carcinoma subtype. The pooled data demonstrated that high PD-L1 expression was associated with poor overall survival and disease-free survival. There was no significant correlation between PD-L1 expression and progression-free survival or disease-specific survival of SGC patients.

Conclusion

According to the meta-analysis, positive PD-L1 expression may play an important role as an effective marker of poor prognosis in patients with SGC. However, large-scale, prospective investigations are still needed to confirm the findings. The assessment of PD-L1 expression may aid in the personalized management of SGC.
Short chain fatty acid, acetate restores ovarian function in experimentally induced PCOS rat model
Authors: Olaniyi Kehinde S. , Bashir Al-amin M. , Areloegbe Stephanie E. , Sabinari Isaiah W. , Akintayo Christopher O. , Oniyide Adesola A. , Aturamu Ayodeji
Published: July 2022

Background

Polycystic ovarian syndrome (PCOS) is pathogenically characterized with hyperandrogenism and metabolic alterations, which often result in ovarian changes and infertility in women of reproductive age. Epigenetic changes have been linked to the development of PCOS. However, the involvement of epigenetic regulator, histone deacetylase (HDAC) in PCOS-driven ovarian dysfunction is not clear. Howbeit, the present study hypothesized that acetate, an HDAC inhibitor (HDACi) would protect against ovarian dysfunction in experimentally induced PCOS.

Materials and methods

Female Wistar rats weighing 120–150 g were randomly divided into four groups (n = 6). The groups received vehicle, sodium acetate (200 mg/kg), letrozole (1 mg/kg) and letrozole with acetate by oral gavage respectively. The administrations were done daily for 21 days.

Results

The rat model of PCOS had increased body weight and ovarian weight, 1-hr postload glucose and plasma insulin, testosterone and LH/FSH ratio as well as reduced insulin sensitivity and plasma 17-β estradiol and sex hormone binding globulin. This model of PCOS in addition showed a significant increase in plasma and ovarian triglyceride, total cholesterol, TNF-α and HDAC, and ovarian malondialdehyde as well as a significant reduction in ovarian glutathione peroxidase/reduced glutathione and NrF2 with the histology of ovarian tissues showing disrupted morphology with significant increase in the number of degenerated follicles compared with control group. These alterations were however attenuated when treated with HDACi, acetate.

Conclusion

Altogether, the present results suggest that acetate protects ovarian function with evidence of normal growing follicles and enhanced circulating 17-β estradiol by inhibition of HDAC.
Participación de las escritoras del exilio republicano español de 1939 en las publicaciones periódicas de su tiempo editadas en México
Authors: Montiel Rayo Francisca
Published: July 2022

Iniciadas sus trayectorias en las primeras décadas del siglo XX –coincidiendo con la inusitada acogida que las publicaciones periódicas españolas les dispensaron a las colaboraciones firmadas por mujeres–, las periodistas y escritoras que se vieron obligadas a exiliarse al término de la Guerra Civil se enfrentaron desde un primer momento a la más que probable posibilidad de que los caminos profesionales que habían logrado trazar con gran esfuerzo se vieran interrumpidos para siempre. En México, donde hacía ya algunos lustros que se había iniciado el proceso de industrialización de la actividad periodística, y donde los refugiados republicanos fundaron un considerable número de cabeceras, no les resultó precisamente fácil ejercer su labor, como puede observarse en esta aproximación al alcance y a la naturaleza de sus colaboraciones en las publicaciones étnicas y autóctonas de su tiempo editadas en México.
Escribir e ilustrar desde el exilio: La revista Mujeres Españolas (México años 50) y sus colaboradoras
Authors: Domínguez Prats Pilar
Published: July 2022

Analizamos el contenido de la revista Mujeres Españolas como parte de la cultura y la memoria de la izquierda marxista española en el exilio. Se trata de una revista femenina, antifranquista, pacifista, una publicación propia de las exiliadas, que quería atraer al mayor número de refugiadas españolas que estuvieran en contra de la dictadura y a favor de la democracia en México. Al estar totalmente volcada hacia temas españoles y exaltar los valores de la patria que encarnaban los partidarios de la República durante la Guerra, puede considerarse nacionalista. Desde una perspectiva de género tiene un discurso maternalista, que exalta los valores tradicionales de la domesticidad. Con este enfoque destacamos la obra de tres de sus más estrechas colaboradoras: Luisa Carnés (directora de la revista), la escritora Felisa Gil y la pintora Manuela Ballester. Resalta la intención ejemplarizante de sus artículos histórico-literarios y la transmisión de una memoria colectiva a través de ellos; una memoria heroica pese a las derrotas de la Guerra de España y el desfavorable contexto internacional.
Estrategias patrimoniales de un gran propietario en el siglo XIX: el marqués de Guadalcázar
Authors: Guisado Domínguez María Auxiliadora
Published: July 2022

A grandes rasgos, la nobleza no sufrió importantes pérdidas tras la aplicación de la reforma agraria liberal, consolidándoles como grandes propietarios, especialmente en Andalucía; estas circunstancias les situarían en una posición inmejorable para promover innovaciones agrícolas en el siglo XIX. Frente a la imagen clásica de una nobleza absentista, pasiva hacia cambios en estructuras organizativas, innovaciones técnicas o inversiones, otras investigaciones ofrecen una visión más dinámica de este grupo social. La casa de Guadalcázar es un buen exponente de una estrategia económica brillante y de cómo la dinámica familiar fue más determinante, causa de su disgregación y de la pérdida de su identidad cordobesa.
En busca de una religión de la patria. Joaquín V. González regeneracionista en la Argentina fin-de-siglo
Authors: Reyes Francisco Jerónimo
Published: July 2022

El presente trabajo aborda un ejemplo especial del fenómeno transnacional que constituyó en el cambio del siglo XIX al siglo XX: el regeneracionismo de Joaquín V. González, miembro a la vez de las elites intelectuales y políticas de la Argentina de entonces. Desde una perspectiva que cruza la historia política con la historia intelectual y de los intelectuales, el foco se posa en el momento de su trayectoria que gira en torno a la crisis de 1890 y las formas de intervención políticas, culturales y estatales de González. A partir del análisis de sus principales obras del período, su labor en el periodismo y su inserción institucional, se sostiene la hipótesis de que esta figura confluyó con otras en torno a la necesidad de una «reacción» que diera lugar a una «regeneración nacional» en el país, a tono con planteos más generales del mundo atlántico finisecular que fueron recibidos por González. La conclusión plantea que el resultado de sus inquietudes en dicho momento se sintetizó en la promoción de una «religión de la patria» capaz de dotar de cohesión espiritual a un país sumido en profundas transformaciones en todos los aspectos de su vida pública.
Lugares de memoria y disputa. El significado de las fosas comunes
Authors: Palacios González Daniel
Published: July 2022

Desde el año 2000 las fosas comunes han sido uno de los componentes centrales de los discursos generados en torno a la «Memoria Histórica». A través de una metodología interdisciplinar se plantea el análisis del significado de estas. Se atenderá a la fosa común en tanto que signo represivo, a cómo en los años setenta comenzaron a ser resignificadas a través de acciones de homenaje sobre las propias fosas comunes y eventualmente a su exhumación, a las acciones sobre las mismas acometidas desde el año 2000 ante el surgimiento de la noción de la «Memoria Histórica». Finalmente se pone en evidencia el carácter conflictivo de esas resignificaciones de la fosa común ante el rechazo a las mismas por diversos medios. Se concluye así que las acciones sobre las fosas comunes se han convertido en un campo para la disputa por el sentido del pasado.
DE LUIS MARTÍN, Francisco, Pablo Iglesias. Muerte y memoria de un mito. Córdoba, Almuzara, 2021, 271 pp.
Authors: Gajate Bajo María
Published: July 2022

Reseña del libro: DE LUIS MARTÍN, Francisco, Pablo Iglesias. Muerte y memoria de un mito. Córdoba, Almuzara, 2021, 271 pp.
FERNÁNDEZ RODRÍGUEZ, Carlos; VALIENTE ORS, Mauricio; VEGA SOMBRÍA, Santiago, Comunistas contra Franco. Madrid, Los libros de la Catarata, 2021
Authors: Alcántara Pérez Pablo
Published: July 2022

Book review: FERNÁNDEZ RODRÍGUEZ, Carlos; VALIENTE ORS, Mauricio; VEGA SOMBRÍA, Santiago, Comunistas contra Franco. Madrid, Los libros de la Catarata, 2021.
Work orientation and flourishing life in twelve Ibero-American countries
Authors:   Universidad Austral, Buenos Aires, Argentina, Mesurado Belén ,   Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina, Idrovo Carlier Sandra ,   Inalde Business School, Universidad de la Sabana, Bogotá, Colombia, Rodríguez Omar ,   Universidad Austral, Buenos Aires, Argentina, Debeljuh Patricia ,   IAE Business School, Universidad Austral, Buenos Aires, Argentina, Crespo Ricardo F. ,   Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina,   IAE Business School, Universidad Austral, Buenos Aires, Argentina
Published: July 2022

Introduction/Objetive: Work orientation includes the individual’s beliefs regarding the role of work in his/her life as a whole and what they are searching for in their careers. There are three types of orientation to work: job, career, and vocation. Work orientation has the distinction of examining how work connects with people’s lives and is, therefore, an appropriate construct for evaluating the impact of work on human flourishing. The aims of this study are first to explore work orientation in twelve Ibero-American countries; and second, to investigate whether work orientation affects flourishing in the lives of adults in twelve Ibero-American countries. Method: A total of 3000 adults participated in this study. The University of Pennsylvania Work-Life Questionnaire was used to evaluate the type of relationship that employees reported having with their work, according to the distinctions between job, career, and calling. A 12-item version of the Multidimensional Flourishing Scale was used to measure three aspects of flourishing: social, psychological, and emotional well-being. Results: Most participants reported a high level of calling in their work orientation. In most countries, those with a calling orientation reported higher levels of social and psychological well-being than those with a job orientation. The results indicate a clear relationship between a calling orientation and social and psychological well-being. Conclusion: This research is the first to compare the relationship between work-orientation and flourishing in Ibero-America. The findings help us understand that work-orientation is not a secondary aspect of a person’s life but has fundamental implications in the lives of workers.
Relationship among merit pay policies, teacher mobility and attrition: A study in the Rio de Janeiro public schools
Authors: Carrasqueira Karina , Koslinski Mariane C.
Published: July 2022

The objective of this work was to verify if there is an association between a merit pay policy practiced by the Rio de Janeiro municipal local administration in the patterns of teachers’ mobility and attrition. The research followed the movement of teachers who took posts in the Rio de Janeiro municipal system between 2009 and 2011 during the eight years the policy was in effect (2009-2016). Bivariate analyses and comparisons with tests of differences in means were performed. The main result was that the number of times the school reached the goals set by the policy and, consequently, the staff received performance pay presented a correlation with teacher mobility and attrition. Thus, the greater the frequency of school reached the performance target, the higher the probability of retaining teachers.
Einbildung et Ent-wurf. Chemin de l’imagination chez Heidegger en 1929–1930
Authors: Mellana Giulio
Published: July 2022

In this article, the author intends to show that the question of the human being as weltbildend, which Heidegger discusses in his lecture on Grundbegriffe der Metaphysik (WS 1929/30), could be helpfully read in light of Kant und das Problem der Metaphysik (1929), so as to appreciate the role played by the destruction (Destruktion) of Kant’s Einbildungskraft in the description of Weltbildung. The latter is only a formal indication (formale Anzeige), which is useful to make thought proceed, but which cannot escape its final destruction. The language of bilden is meant to be dissolved in another language. In this contribution, particular attention is given to the concluding paragraph 76 of Grundbegriffe der Metaphysik, by insisting on the notion of Ent-wurf.
Are Public Relation Strategies Useful for Ghanaian Public Universities: An Exploratory Inquiry on the University of Education, Winneba in Ghana
Authors: Kankam George
Published: July 2022

Universities in the twenty-first century must use successful public relations methods to communicate with both external and internal audiences. Ghana's public universities are dedicated to change, which necessitates the creation of public relations techniques to increase student enrolment. The exploratory inquiry was used in this study. The consequences of public relations tactics on public relations strategies at Ghanaian public universities are examined in this paper. Based on the existing literature, it is concluded that public universities use a variety of marketing public relations strategies to increase student enrollment, including television advertising, radio advertising and web page information. However, there is still room for improvement, and practical recommendations are made.
Fundamentalne elementy w budowaniu autentycznej duchowości eucharystycznej w adhortacji Sacramentum Caritatis Benedykta XVI
Authors: Kwiatkowski Dariusz
Published: July 2022

Celem artykułu jest ukazanie fundamentalnych elementów budowania autentycznej duchowości eucharystycznej. Zagadnienie wydaje się ważne i aktualne, gdyż dziś można zaobserwować u wielu katolików zjawisko subiektywnego oceniania własnego uczestnictwa i przeżywania Eucharystii. Niektórzy wierni szukają w Eucharystii mocnych doświadczeń emocjonalnych związanych z wprowadzaniem do celebracji elementów światła, głośnej muzyki, dodawaniem różnych gestów: nakładania rąk, modlitwy o uzdrowienie, namaszczania różnymi olejkami, zjawisk omdlenia i głośnego śmiechu przypisywanych działaniu Ducha Świętego. Oznacza to dla nich szukanie „lepszej” Eucharystii. W tym miejscu rodzi się pytanie: Czy może być lepsza i gorsza Eucharystia? Odpowiadając a postawione pytania, staraliśmy się pokazać najważniejsze elementy budujące autentyczną duchowość eucharystyczną. Na podstawie adhortacji apostolskiej Benedykta XVI Sacramentum Caritatis wskazaliśmy na następujące fundamenty autentycznej duchowości eucharystycznej: jedność Eucharystii z całym chrześcijańskim wtajemniczeniem, wiarę budowaną na słuchaniu słowa Bożego i wypływający z Eucharystii duch służby obecny w codziennym życiu chrześcijanina. Poznanie tych elementów pozwala widzieć, że Eucharystia jest zawsze jedna i ta sama, gdyż zawsze uobecnia niepowtarzalne misterium paschalne Chrystusa dokonane dla zbawienia ludzkości.
ترجمات ودراسات أعمال الكاتب الصيني لو شون في مصر / Translations and Studies of the Works of Chinese Writer Lu Xun in Egypt
Authors: Fahmy Hussein Hassanein
Published: July 2022

The Chinese writer Lu Xun (1881-1936) is considered one of the most important writers in the history of Chinese literature. His works have been translated over the years into many foreign languages, including Arabic. In addition to translating his works, foreign researchers have presented many studies on his thought and literature, and Lu Xun’s studies and translations into Arabic played an important role in introducing Lu Xun’s creativity and thought and even modern Chinese literature in general, and these translations had a clear impact on the influence of a number of Egyptian and Arab writers on literature, like Egyptian writer Abdel Ghaffar Makawy and Syrian writer Olfat Al-Idlibi. With the development witnessed by the specialization of Chinese language and literature in Egypt, Lu Xun studies in Egypt saw a remarkable progress. A number of Egyptian researchers presented Chinese-language studies on Lu Xun literature in addition to studies that are presented from a comparative point of view between Lu Xun and a number of Egyptian writers.
الصورة الأدبية لنجيب محفوظ في الصين / Naguib Mahfouz’s Literary Image in China
Authors: Shuhong Ding
Published: July 2022

Adopting a translation criticism approach of descriptive analysis, the thesis, from a cross-cultural perspective, combs through the development about translation, introduction and the acceptance of Naguib Mahfouz by the Chinese before and after he won the Nobel Prize in Literature. After a synchronic and diachronic study of the attitudes and ways of acceptance for Mahfouz during different periods, the thesis unravels the process in which Mahfouz’s literary image has developed from a simple “teller of social problems” to a sophisticated “writer of the world.” Besides, the thesis explores the Chinese scholars’ cultural filtering and value orientation towards Mahfouz, oriental writer and Nobel laureate, as well as Mahfouz’s influence and constraints of China’s present cultural and linguistic contexts.
التعاون الصيني العربي في مجال الفضاء: الفرص والتحديات / Sino-Arab Space Cooperation: Opportunities and Challenges
Authors: Berro Tamara
Published: July 2022

In recent years, space has become a new area of cooperation between China and Arab countries. This cooperation, based on mutual respect, openness, equality and mutual benefit, is of great importance due to its role in developing and strengthening relations between the two sides and pushing them forward. Despite the progress witnessed by the Chinese-Arab relations in the field of space sciences, there are challenges facing space cooperation between the two sides, relating to the conditions of some Arab countries that have suffered wars, and political, economic and social crises, in addition to the relationship that links the countries of the region with some major countries. This research sheds light on the space program of China and shows how this country has made great progress in the field of space sciences, it also includes the space program of Arabic countries, some of which have recently witnessed a remarkable development in space sciences, trying to catch up with the more developed countries in this field. This research also discusses the cooperation between China and Arab countries, stresses the importance of this cooperation, and puts forward the challenges that could impede the process of space cooperation.
The system’s genetics of depression and its somatic and mental comorbidities
Authors: Kalinichenko Liubov S. , Kornhuber Johannes , Müller Christian P.
Published: July 2022

Depression is a common mood disorder characterised by high comorbidity with other mental and somatic diseases. New studies reveal a shared genetic base for mental core symptoms and somatic comorbidities. Functional analyses showed multiple brain–body pathways involved. This may help considering new therapeutic approaches for depression as a system’s disorder.
Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach
Authors: Cicia Alessandra , Nociti Viviana , Bianco Assunta , De Fino Chiara , Carlomagno Vincenzo , Mirabella Massimiliano , Lucchini Matteo
Published: July 2022

Neurosarcoidosis is an uncommon and multiform clinical entity. Its presentation as an isolated longitudinal extensive transverse myelitis (LETM) is rare and challenging to identify. We report a case of LETM in a 60-year-old patient with no significant systemic symptoms nor relevant medical history. The peculiar spinal magnetic resonance imaging finding characterized by a posterior and central canal subpial contrast enhancement, the so-called “trident sign,” together with chest computed tomography scan and lymph node biopsy led to the diagnosis of sarcoidosis. We also discuss the main differential diagnoses of LETM and therapeutic options for sarcoidosis-related myelitis.
“A Pledge of Allegiance to the South”
Authors: Potter Amy E.
Published: July 2022

Research examining representations of the institution of slavery at historic house museums in the United States has overwhelmingly privileged southern plantation museums. Increasingly, however, there is a call to resist the urge to center discussions of enslavement only in the South and to expand our understandings of how slavery permeated all aspects of US society. Utilizing interviews, narrative mapping, and visitor surveys, this study seeks to show how two house museums in Kansas City, Missouri, are commemorating enslavement. This research is part of the larger initiative of Tourism RESET (Race, Ethnicity and Social Equity in Tourism).
“Restoring” Charleston’s Dock Street Theatre
Authors: Gray Stephanie
Published: July 2022

The imaginative reconstruction of the Dock Street Theatre, completed between 1935 and 1937 in Charleston, South Carolina, was a New Deal experiment in historic preservation. Funded by the Works Progress Administration (WPA) and led by local architects Albert Simons and Samuel Lapham, the orchestrated re-creation of a lost eighteenth-century theater reflected the white elite’s desire to immortalize the city’s prosperous colonial and antebellum past in the historic built environment. While the project courted conservative interests and created a romanticized version of Old Charleston, the strong support of Democratic mayor Burnet Maybank and WPA director Harry L. Hopkins simultaneously pushed forward a progressive southern agenda. This dual and contradictory set of motivations culminated in an intriguing use of historic preservation to nurture a particular community’s sense of place and use historic buildings as a catalyst for cultural rebirth.
Determination of hybrid-seed genetic purity in wax gourd using newly developed InDel markers based on whole-genome resequencing
Authors: Lv Haixuan , Su Liwen , Wu Wenting , Huang Xiaochun , Liu Ting , Nong Lifeng , Yang Wenrui , Chen Yong , Wangh Peng , Liu Zhengguo
Published: July 2022

Wax gourd (Benincasa hispida) is highly appreciated for its nutritional and therapeutic value, especially throughout Asia. As the market for wax gourd expands, new varieties of unknown purity are being promoted. In this study, the unpublished 'GX-19' wax gourd genome elucidated
by our research group was used as reference genome. Two high-generation inbred lines ('HX-1' and 'HX-6') were resequenced and 330 pairs of InDel primers were designed and synthesised. Following screening, 11 pairs of InDel markers were identified and used to determine the degree of genetic
purity of wax-gourd hybrid seeds. InDel molecular markers were used to identify the purity of 17 hybrids, including 'Lvxianzi 2', 'Fenxianzi 1', 'Jinyuan 1', 'Yinyuan 4', 'Chunfeng 868', 'Xinjinyu' and 'Meihua 8'. Additionally, we showed that the amplification fragment from DNA extracted using
the alkali rapid-extraction method developed in this study was identical to that of the fragment amplified from DNA extracted using a modified CTAB method. When the InDel molecular marker-based purity determination of five wax gourd hybrids was compared with that using the growing out test,
the results were highly consistent. A stable, accurate, efficient and straightforward approach is provided to determine the genetic purity of hybrid wax gourd seeds.
IGFBP7 enhances trophoblast invasion via IGF-1R/c-Jun signaling in unexplained recurrent spontaneous abortion
Authors: Wu Pei-Li , Zhu Jing-Wen , Zeng Cheng , Li Xin , Xue Qing , Yang Hui-Xia
Published: July 2022

In brief

Insufficient trophoblast invasion at the maternal–fetal interface contributes to abortion-prone pregnancy. Our study shows that decreased levels of IGFBP7 in unexplained recurrent spontaneous abortion (URSA) trophoblast cells inhibit MMP2 and Slug expression as well as trophoblast invasion, suggesting that IGFBP7 should be considered a potential therapeutic protein target in URSA.

Insufficient trophoblast invasion at the maternal–fetal interface contributes to abortion-prone pregnancy. Cyclosporine A (CsA) can exert therapeutic effects on URSA by promoting trophoblast invasion. A previous study showed decreased expression of insulin-like growth factor-binding protein 7 (IGFBP7) in the sera of recurrent spontaneous abortion patients. However, the role of IGFBP7 in URSA remains unknown. The aim of this study was to determine whether IGFBP7 modulates trophoblast invasion in URSA and the underlying molecular mechanisms. We found that IGFBP7 was expressed at lower levels in villous specimens from URSA patients. Manipulating IGFBP7 expression significantly affected the MMP2 and Slug expression in HTR-8/SVneo cells as well as trophoblast invasion in vitro. Inactivation of IGF-1R by IGFBP7 was observed, and IGF-1R inhibition increased the IGFBP7-induced MMP2 and Slug expression in HTR-8/SVneo cells. Moreover, the level of c-Jun was significantly upregulated in the URSA group. Silencing IGFBP7 increased the binding of downstream c-Jun to the MMP2 and Slug promoter regions in HTR-8/SVneo cells, thus suppressing transcription. In addition, increased expression of IGFBP7 in HTR-8/SVneo cells was observed upon CsA treatment. Knockdown of IGFBP7 inhibited the CsA-enhanced MMP2 and Slug expression in HTR-8/SVneo cells. Our results suggest that in normal pregnancy, IGFBP7 induces MMP2 and Slug expression via the IGF-1R-mediated c-Jun signaling pathway, thereby promoting trophoblast invasion. IGFBP7 depletion in URSA inhibits MMP2 and Slug expression as well as trophoblast invasion. Moreover, IGFBP7 participates in CsA-induced trophoblast invasion, suggesting that IGFBP7 is a potential therapeutic target for URSA.
Galimai pavojingų cheminių elementų kaita Lietuvos pajūrio paplūdimių sąnašose
Authors:   , Kažukauskienė Ieva
Published: July 2022

Change in Potentially Harmful Elements in the Beach Sediments of a Seacoast
Prognostic Utility of Myocardial, Serum and Echocardiographic Biomarkers in Patients with Non-Ischemic Dilated Cardiomyopathy
Authors:   , Kažukauskienė Ieva
Published: July 2022

Neišeminės dilatacinės kardiomiopatijos seruminių, miokardinių ir echokardiografinių žymenų prognostinės vertės tyrimai
Namen und Macht in Mosambik
Authors: Jahn Susanne
Published: July 2022

Während sich auf vielen virtuell zugänglichen Karten Mosambiks noch zahlreiche Toponyme aus der Kolonialzeit finden lassen, die seit Erlangung der Eigenstaatlichkeit 1975 eigentlich längst (wieder) einen afrikanischen Namen tragen, wird die Kritik im Land an der unauthentischen Schreibung autochthoner Ortsnamen lauter. Hinter dieser steht der Gedanke, dass nur durch ein konsequentes ,desaportuguesamento‘ (Ngunga 2021) der Namenslandschaft Mosambiks im Einklang mit den jeweiligen Lokalsprachen der Bantugruppe die endgültige Befreiung vom (portugiesischen) Kolonialismus erreicht und die eigene nationale Identität gestärkt werden könne. Allerdings steht dabei auch eine Einrichtung wie das 2009 geschaffene Instituto Nacional de Nomes Geográficos Moçambicanos (INGEMO) u. a. vor dem Problem, inwieweit die angestrebte Harmonisierung der Ortsnamen angesichts der Tatsache, dass die ursprüngliche Bedeutung der Namen in den ihnen zugrunde liegenden Sprachen oft kaum noch rekonstruierbar sind, ihrerseits mehr als symbolischer Natur sein und etwa historisch-linguistischen Kriterien standhalten kann.
Romance (Catherine Breillat, 1999)
Authors: Belot Sophie , Junkerjürgen Ralf
Published: July 2022

Der vorliegende Beitrag analysiert die Entwicklung der Figur Marie in Catherine Breillats Film Romance (1999), die sowohl aus einer kulturellen (Romanze und Pornografie), als auch einer sozialen Perspektive (männliche Dominanz) dargestellt wird. Breillats Film wird oft von (Nicht-)Feministinnen kritisiert. Die vorliegende Untersuchung möchte dieser Kritik entgegenwirken und aufzeigen, dass Romance ein System permanenter und gewalttätiger Gegensätze angreift, um die Frau von unterwürfigen und feindlichen Darstellungen (wie Pornografie und Romanze) zu befreien, die ein entfremdetes Bild von ihr entwerfen. Es soll gezeigt werden, dass Breillat mit Romance die männliche Dominanz über die Frau anprangert. Dabei, so die Argumentation, konzentriert sich die Filmemacherin auf die Darstellung der Jungfräulichkeit oder Reinheit der weiblichen Figur, um weibliche Sexualität als ein tabuisiertes Thema zu entlarven.
Aus dem Französichen von Ralf Junkerjürgen
Error detection in binary code with dynamic symbolic execution
Authors: Vishnyakov Alexey , Kobrin Eli , Fedotov Andrey
Published: July 2022

Modern software is rapidly developing, revealing new program errors. More and more companies follow security development lifecycle (SDL). Fuzzing and symbolic execution are among the most popular options for supporting SDL. They allow to automatically test programs and find errors. Hybrid fuzzing is one of the most effective ways to test programs, which combines these two techniques. Checking security predicates during symbolic execution is an advanced technique, which focuses on solving extra constraints for input data to find an error and generate an input file to reproduce it. In this paper we propose a method for automatically detecting errors with the help of dynamic symbolic execution, combining hybrid fuzzing and checking security predicates. Firstly, we run hybrid fuzzing, which is required to increase number of corpora seeds. Then we minimize corpora. Thus, it would give the same coverage as the original corpora. After that we check security predicates on minimized corpora. Thus, security predicates allow to find errors like division by zero, out of bounds access, integer overflow, and more. Security predicates results are later verified with sanitizers to filter false positive results. As a result of applying the proposed method to different open source programs, we found 11 new different errors in 5 projects.
ÉLITES, IMPUESTOS Y DESIGUALDAD SOCIAL EN LA COSTA RICA NEOLIBERAL
Authors: Arias Chavarría Esteban
Published: July 2022

Este trabajo parte de las premisas y categorías de la sociología fiscal para analizar la relación entre impuestos, desigualdad social, conflictividad fiscal y élites empresariales. La metodología se basa en la comparación de tres coyunturas fiscales entre los años 2000-2018, así como la recopilación de información estadística relevante. Se indagan tres coyunturas fiscales y se observa de cerca la relación tributaria entre el Estado fiscal y las élites empresariales. Esto permite descubrir los factores macro-sociológicos detrás del régimen fiscal costarricense en el contexto neoliberal.
NATURALEZA DE LA POLÍTICA MIGRATORIA Y LA INFLUENCIA DEL ‘SIEMPRE PRESENTE’ CONTEXTO
Authors: Rivera María José
Published: July 2022

El objetivo de este artículo es ofrecer una alternativa de reflexión teórica sobre la naturaleza político-filosófica de las políticas migratorias. La metodología consistió en un estudio de caso del proceso migratorio Ecuador-España (1997-2014). Se encontró que las políticas migratorias en fenómenos Sur-Norte están definidas por factores altamente contextuales que afirman asimetrías de poderes entre Estados, tanto Sur-Norte como Norte-Norte. La naturaleza de las políticas migratorias no responde al nivel micro, pero el migrante y su familia crean estrategias de ajuste y adaptación.
APUNTES SOBRE LA HISTORIA Y LA MEMORIA A TRAVÉS DE LA IMAGEN
Authors: Navarro Fuentes Carlos Alberto
Published: July 2022

El objetivo del ensayo es plantear la relación que la imagen sostiene con la historia y lamemoria como formas de aproximación al pasado. La metodología consistió en revisarla manera en que la disciplina histórica —y otras ciencias sociales— ha empleadola imagen como herramienta para estudiar mundos sociales, al identificar avances ylimitaciones en esta materia. Se concluye que esta tiene un papel fundamental en losprocesos de configuración de la memoria colectiva, especialmente donde experienciastraumáticas han tenido lugar.
Fabrication and Shipment Cracks in Prestressed Hollow-Core Slabs and Double Tees
Authors:   PCI Committee on Quality  Control Performance Criteria
Published: July 2022

This report is a catalogue of cracks which can occur in prestressed hollow-core slabs and double tees during the casting, stripping or shipment of the product. It is intended to serve as a guide to identify typical cracks occurring in production and shipping of hollow-core slabs and double tees. The report can be used by the plant or production manager and quality control supervisor to identify casting, stripping or shipping cracks which can originate from numerous sources.
Overcoming issues in frequency-based extraction and lexicographic lnclusion of Korean neologisms
Authors: Nam Kilim
Published: July 2022

This paper discusses issues regarding frequency as a criterion for Korean neologism extraction from the perspective of corpus linguistics and lexicography. Most studies agree that frequency plays a central role in the inclusion of neologisms in the dictionary; however, frequency entails a number of complex factors such as the time span of a word’s use as well as the variety of registers. The use of web data to extract neologisms – instead of a balanced corpus – has brought about a new range of issues that call for new ways to address them. Section 2 reviews previous research trends related to neologism frequency from the point of view of linguistics and neologism studies. Section 3 examines and discusses issues in the detection of phrasal and semantic neologisms, and in the use of Web corpora. Section 4 suggests the use of triangulation in order to cope with such shortcomings, combining use-based methodology and used-based approach.
Whither Chinese–English lexicography? – From a historical perspective
Authors: Gao Yongwei
Published: July 2022

2020 marked the 200th anniversary of the publication of the second part of Robert Morrison’s A Dictionary of the Chinese Language which has been widely recognized as the first Chinese–English (hereinafter abbreviated to C–E) dictionary and signaled the beginning of C–E lexicography. From the late Qing Dynasty to the present, literally several hundred C–E dictionaries, small or large, have been compiled, though the number of noteworthy ones is rather limited. Nevertheless, research into C–E lexicography has gradually developed into a distinct field of study as witnessed by thousands of academic papers and over a dozen books devoted to its research. A search of (Chinese–English dictionary) as the keyword in CNKI, a database of journal articles, theses, and dissertations written in the Chinese language, came up with 8,365 results. Most of the discussions center round topics such as dictionary criticism, history of dictionary-making, theoretical construction, and case studies. The history of bilingual lexicography in China, for instance, was under-researched in the past as a result of the lack of original copies of early dictionaries, which, however, has been improved thanks to the reprinting and wide availability of such dictionaries since the beginning of the 21st century. Chinese Lexicography: A History from 1046 BC to AD 1911 (Heming Yong et al., 2008), for instance, devoted only a few pages to the earliest history of C–E lexicography which spans more than 70 years. But now dozens of academic papers and even several books (e.g. Yang, 2012; Gao, 2014) have been written about the early bilingual dictionary-makers and their lexicographical works, presenting a clear picture of the evolution of C–E lexicography. Today more than two decades into the 21st century, the C–E lexicography scene is not as crowded as its English–Chinese counterpart as there are only a few major players. The paper aims to present a brief history of C–E lexicography with a focus on lexicographical tradition and creativity, elaborate on the deficiencies or problems found within the major C–E dictionaries, and finally discuss the future directions of C–E lexicography.
Sinicization as glocalization in The Chinese English Dictionary
Authors: Ding Jun
Published: July 2022

This study explores the Chineseness on different levels as displayed in the lexicographic text of The Chinese English Dictionary (unabridged, 1st volume, 2015) (CED) and interprets it as Sinicization informed by the spirit of glocalization. Adopting the discourse approach proposed by Chen (2019) as CLDS (Critical Lexicographical Discourse Studies), it views CED as discourse and aims to examine and reveal how the dominant ideological powers within Chinese society may have borne on the dictionary’s distinct Sinicizing efforts. It proposes that CED has effectively challenged the established norms of bilingual lexicography involving English in mainland China in its negotiating Chinese into sharing the status of target language with English and infusing the dictionary text with rich traditional Chinese culture. Meanwhile, CED also demonstrates strong glocalizing tendencies in its consistent ‘de-ideologizing’ efforts in the treatment of historic-political and cultural terms, as well as its unusual emphasis on acculturation as a translation guideline which serves well to universalize the local and vice versa.
The treatment of phraseology in Chinese–English dictionaries and Chinese dictionaries for learners
Authors: Zhang Xuhua , Gander Anna Jia
Published: July 2022

There is little doubt that phraseology is at the heart of all language use. This paper examines the treatment of phraseology in two influential Chinese–English dictionaries and four Chinese dictionaries for learners. Two high-frequency characters, namely eat and hit, were selected due to their highly polysemous and phraseological nature, and their phraseological behaviors examined in the Lancaster Corpus of Mandarin Chinese. The entries in the Chinese–English dictionaries and Chinese dictionaries for learners for eat and hit were examined and their dictionary records compared with the results of the previous corpus-based study. The corpus-based identification and categorization of the phraseological behaviors of eat and hit revealed that some multi-character expressions could not be covered by the terms offered by the existing taxonomy (Sag et al., 2002). Accordingly, the taxonomy was revised for the appropriate categorization of Chinese phraseology. Comparisons between corpus-based findings and entry records in Chinese–English dictionaries showed a convergence in the overall treatment of phraseology in Chinese–English dictionaries. By contrast, inconsistencies in the learners’ dictionaries were observed. It was also found that the two Chinese–English dictionaries agree with each other on the overall inclusion and exclusion of phrases. Again, we also observed many differences in the way phrases are treated between Chinese–English dictionaries and learners’ dictionaries and also among the four learners’ dictionaries. It is worth noting that hardly any of the verb-particle constructions observed in the corpus are included in the dictionaries under observation. We propose that these constructions should also be treated as phrases and the dictionaries would be more user-friendly if these phrases were not hidden in the other longer phrases, and were given the same status as the headwords. A larger corpus and sampling in the future would better characterize the taxonomy of Chinese phraseology and provide more conclusive findings.
Primary Stability of Trabecular Metal Implant in Comparison to Fully Threaded Implants: In Vitro Study Simulating Immediate Implant Placement
Authors: Magic Marko , Zupanek Gorana , Lazic Zoran , El Chaar Edgard
Published: July 2022

The aim of this study was to evaluate primary stability of 3.7-mm diameter porous tantalum Trabecular Metal (TM) implant, and compare it to fully threaded implants, in the in vitro model of immediate implant placement in the anterior maxilla. A total of 60 implants were placed into bovine ribs using surgical guides. Implants were divided in 3 groups of 20 according to the design: TM, Tapered Screw-Vent (TSV), and NobelReplace. To simulate immediate placement in anterior maxilla, implants were placed under a sharp angle toward the ribs, not fully submerged. Placement angle of 20.7° was calculated after analysis of 148 virtually planned implants on cone beam computerized tomography scans of 40 patients. No statistically significant difference in implant stability quotient (ISQ) was found between TM (65.8 ± 2.6), TSV (64.7 ± 2.7), and NobelReplace (64.6 ± 2.7). TSV implants achieved higher insertion torque (37.0 ± 4.8 Ncm) than TM (32.9 ± 5.2 Ncm) and NobelReplace (23.2 ± 3.3 Ncm). TSV had the shortest insertion time of 13.5 ± 1.0 seconds, compared to 15.2 ± 1.2 seconds for TM, and 19.7 ± 1.7 seconds for NobelReplace. Pearson correlation analysis showed significantly correlated insertion torque and ISQ values for TM group (P = .011, r = .56), a nonsignificant correlation was found for TSV and NobelReplace. The results of the present study indicate that TM implant can achieve good primary implant stability in insertion torque and resonance frequency analysis.
Successful Management of Apically Exposed Implants in the Maxillary Sinus and Associated Sinus Pathologies Via Maxillary Sinus Floor Augmentation
Authors: Park Won-Bae , Park Wonhee , Han Ji-Young , Kang Philip
Published: July 2022

One common complication with dental implants placed in the atrophic posterior maxilla, especially with simultaneous transcrestal sinus augmentation, is the implant protruding into the sinus without apical bone support. Frequently, apically exposed implants contribute to various sinus pathologies that may lead to implant failure. Treatment options include (1) managing asymptomatic sinus pathology; (2) regrafting the apically exposed portion of the implant(s); and (3) removing the implant and placing a new implant with simultaneous grafting. The purpose of this case report is to present 4 clinical cases of apically exposed implants in the maxillary sinus. The report will cover: (1) exposed implants with asymptomatic sinus pathologies and (2) show successful management of protruding implants and pathologies using maxillary sinus floor augmentation. Various methods of implant surface detoxification, mechanical and chemical, are described for predictable bone remodeling around existing implants as well as newly installed implants. After 6 months of healing, osseointegration was well achieved for all implants and sinonasal complications were not observed. Clinical photographs and 3-dimensional imaging of surgical sites were used to validate clinical assessments.
Digital Implant Dentistry Predoctoral Program at University of Kentucky
Authors: Kutkut Ahmad , Okeson Jeffrey
Published: July 2022

This report describes the predoctoral comprehensive digital implant dentistry program at the University of Kentucky, College of Dentistry (UKCD). UKCD has implemented a digital dentistry workflow in the dental curriculum for predoctoral and graduate programs since 2018. Digital implant dentistry education involves using cone beam computed tomography (CBCT) for diagnosis and treatment planning, intraoral scanner for digital impression, and treatment planning software to plan for single implant-supported restorations and implant-retained mandibular overdenture cases. The laboratory components include virtual designing of a surgical guide and using three-dimensional printing to fabricate a fully guided surgical template for implant placement procedures for the patient. In the last 3 years, including the COVID year, a total of 294 implants have been placed by dental students. Unfortunately, 6 implants failed in the early healing time due to infection, with an overall success rate of 98%. These treatment outcomes are very favorable compared with published literature.
Estimation of underreporting of energy intake using different methods in a subsample of the ELSA-Brasil study
Authors: Oliveira Priscila Santana , Levy Jéssica , Carli Eduardo De , Bensenor Isabela Judith Martins , Lotufo Paulo Andrade , Pereira Rosangela Alves , Yokoo Edna Massae , Sichieri Rosely , Crispim Sandra Patricia , Marchioni Dirce Maria Lobo
Published: July 2022

Existing methods for assessing food consumption are subject to measurement errors, especially the underreporting of energy intake, characterized by reporting energy intake below the minimum necessary to maintain body weight. This study aimed to compare the identification of energy intake underreporters using different predictive equations and instruments to collect dietary data. The study was conducted with 101 selected participants in the third wave of the Longitudinal Study of Adult Health (ELSA-Brasil) at the University Hospital of the University of São Paulo. For the dietary assessment, we applied a food frequency questionnaire (FFQ), two 24-hour diet recall (24hR) using the GloboDiet software, and two 24hR using the Brasil-Nutri software. The energy intake underreport obtained from the FFQ was 13%, 16%, and 1% using the equations proposed by Goldberg et al. (1991), Black (2000), and McCrory et al. (2002), respectively. With these same equations, the 24hR described an underreport of 9.9%, 14.9%, and 0.9% respectively with the GloboDiet software and 14.7%, 15.8%, and 1.1% respectively with the Brasil-Nutri software. We verified a low prevalence of underreported energy intake among the three self-report-based dietary data collection methods (FFQ, 24hR with GloboDiet, and Brasil-Nutri). Though no statistically significant differences were found among three methods, the equations for each method differed among them. The agreement of energy intake between the methods was very similar, but the best was between GloboDiet and Brasil-Nutri.