bluuebunny/crossref_metadata_2025 huggingface dataset:
Koreksi Bias Data Hujan Proyeksi Coupled Model Intercomparison Project Phase 6 (Cmip6) Di Kota Bima
Authors: Hartawan I Putu , Ibnu Malik Muhamad Zaky , Qhairaan Laifhan Setyo , Wiralino Ken , Rustiawan Irfani Zahira , Wisanggeni Dimas Harya
Published: January 2025

Perubahan iklim global telah memengaruhi pola curah hujan, khususnya di wilayah tropis, termasuk Kota Bima. Model proyeksi iklim seperti Coupled Model Intercomparison Project Phase 6 (CMIP6) menyediakan data penting untuk memprediksi perubahan iklim, namun sering kali mengandung bias yang signifikan. Penelitian ini bertujuan untuk melakukan koreksi bias pada data proyeksi curah hujan CMIP6 menggunakan lima model dalam skenario SSP5-8.5, yaitu CMCC-CM2-SR5, CESM2-WACCM, ACCESS-CM2, CESM2, dan AWI-CM-1-1-MR, dengan mengintegrasikan data historis dari Global Precipitation Climatology Centre (GPCC) dan data lokal dari BMKG.
Hasil penelitian menunjukkan bahwa data historis GPCC memiliki korelasi yang sangat kuat dengan data BMKG, dengan nilai koefisien korelasi sebesar 0,97 dan RMSE sebesar 34,41 mm. Hasil koreksi bias data proyeksi menunjukkan bahwa empat model (CESM2-WACCM, ACCESS-CM2, CESM2, dan AWI-CM-1-1-MR) memiliki pola tren yang serupa berdasarkan analisis Weibull plotting. Sementara itu, model CMCC-CM2-SR5 menunjukkan penyimpangan pola yang signifikan.
Implikasi penelitian ini adalah meningkatkan akurasi proyeksi curah hujan untuk mendukung perencanaan mitigasi risiko bencana dan pengelolaan sumber daya air di Kota Bima. Penelitian ini juga membuka peluang untuk pengembangan metode koreksi bias yang lebih efisien dengan mengintegrasikan teknologi pembelajaran mesin dan data lokal yang lebih rinci.
Finding Reproducible and Prognostic Radiomic Features in Variable Slice Thickness Contrast Enhanced CT of Colorectal Liver Metastases
Authors: Peoples Jacob J. , Hamghalam Mohammad , James Imani , Wasim Maida , Gangai Natalie , Kang Hyunseon Christine , Rong X. John , Chun Yun Shin , Do Richard K. G. , Simpson Amber L.
Published: January 2025

Establishing the reproducibility of radiomic signatures is a critical step in the path to clinical adoption of quantitative imaging biomarkers; however, radiomic signatures must also be meaningfully related to an outcome of clinical importance to be of value for per- sonalized medicine. In this study, we analyze both the reproducibility and prognostic value of radiomic features extracted from the liver parenchyma and largest liver metastases in contrast enhanced CT scans of patients with colorectal liver metastases (CRLM). A prospective cohort of 81 patients from two major US cancer centers was used to establish the reproducibility of radiomic features extracted from images reconstructed with different slice thicknesses. A publicly available, single-center cohort of 197 preoperative scans from patients who underwent hepatic resection for treatment of CRLM was used to evaluate the prognostic value of features and models to predict overall survival. A standard set of 93 features was extracted from all images using pyradiomics, with a set of eight different extractor settings. Our results show that the feature extraction settings producing the most reproducible, as well as the most prognostically discriminative feature values are highly dependent on both the region of interest and the specific feature in question. While the best overall predictive model was produced using features extracted with a particular setting, without accounting for reproducibility, (C-index = 0.630 (0.603–0.649)) an equivalent-performing model (C-index = 0.629 (0.605–0.645)) was produced by pooling features from all extraction settings, and thresholding features with low reproducibility (CCC ≥ 0.85), prior to feature selection. Our findings support a data-driven approach to feature extraction and selection, preferring the inclusion of many features, and narrowing feature selection based on feature reproducibility when relevant reproducibility data is available. Further research is needed to determine how to select reproducible feature sets when reproducibility data is not available.
Issues Facing Implementation of Edo State Public Procurement Law in Construction Projects: Threat to Achieving Sustainable Development Goal 11
Authors: Hafez Mohamed Ahmed , Ebekozien Andrew , Umaigba Godsent Ige , Thwala Wellington Didibhuku , Muda Zakaria Che
Published: January 2025

Studies showed that unethical practices in public procurement may hinder construction projects and economic development, particularly in developing cities and states, such as Edo State, Nigeria. The Nigerian Government enacted the Public Procurement Act (2007) to address the issues. Many states domesticated the Act, including Edo State (Edo State Public Procurement Law (ESPPL) 2020). However, implementation in some states may be challenging and can thwart achieving Sustainable Development Goal 11 (Sustainable Cities and Communities – SDG 11). This study investigated ESPPL implementation issues in construction projects and their outcome to Goal 11. It also proffered ways to boost implementation and, by extension, improve achieving SDG 11 and related SDGs. The researchers engaged knowledgeable respondents within Edo State, Nigeria, via a questionnaire survey approach. This study analysed the collected data with descriptive statistics. The results showed that the issues facing ESPPL implementation can hinder the achievement of Goal 11 if not curbed. As part of the study’s implication, the researchers proffered measures to mitigate the issues and, by extension, improved the achievement of Goal 11 and other SDGs related to construction project performance and excellence.
A Bibliometric Analysis on Corporate Social Responsibility in the Tourism Sector between 2018-2023
Authors: Ateş Alper
Published: January 2025

The tourism literature on corporate social responsibility has significantly expanded in the last decade due to the increased practices of tourism businesses. Tourism companies have implemented Corporate Social Responsibility (CSR) initiatives to promote economic and environmental benefits while demonstrating socially responsible behavior. Tourism companies generally have CSR initiatives that enhance environmental, economic, and social sustainability, involving strategies to promote positive impacts and prevent negative ones. This study aims to analyze the content of studies on CSR in the tourism sector from 2018 to 2023 in the Web of Science (Wos) database. Recent research on CSR has focused on organizational and stakeholder themes. Recent CSR research has shifted its focus from financial to customer-related concerns. Practitioners are urged to assess past corporate social responsibility efforts and create new initiatives in their respective fields. Academics should explore under-researched areas within the field to contribute to advancing CSR research. Seven potential research areas in the tourism sector have been suggested, including secondary stakeholders like residents, government, media, and activists; consequences and antecedents of corporate social responsibility practices; negative aspects of CSR; communication strategies; less explored contexts and topics; and innovative analytical approaches.
Enflasyonist Ortamda Yabancı Sermayeli Mevduat Bankalarının Öz Sermaye Kârlılığına Etki Eden Faktörlerin Belirlenmesi
Authors: Özgür Ersan
Published: January 2025

Türkiye’de mevcut faaliyette bulunan yabancı sermayeli mevduat bankaları 2022 yılı itibariyle bankacılık sektöründe toplam aktifler yönünden %20 paya ulaşmış bulunmaktadır. Bu çalışma ile yabancı sermayeli bankaların enflasyonist ortamda öz sermaye kârlılıklarını etkileyen faktörlerin tespit edilmesi amaçlanmıştır. Panel veri analizi uygulanması gerçekleştirilen çalışmada bağımlı değişken olarak Net Kâr / Öz Sermaye oranı kullanılmıştır. Çalışmaya göre; bir dışsal değişken olarak enflasyon oranının öz sermaye kârlılığına pozitif etkisinin olduğu ve enflasyon arttıkça öz sermaye kârlılığının da arttığı, 2017 yılında başlayan ve takip eden yıllarda hızla artan yüksek enflasyonlu dönemde ise enflasyonun öz sermaye kârlılığı ile istatistiki olarak anlamlı bir ilişkisinin olmadığı sonucuna ulaşılmıştır. Elde edilen analiz sonuçları değerlendirildiğinde ise, modelin anlamlı ve bağımsız değişkenlerin bağımlı değişkeni açıklama gücünün %53.98 oranında olduğu ortaya çıkmıştır. Bağımsız değişkenlerden FGEL ve ENF %1 anlamlılık düzeyinde öz sermaye kârlılığı üzerinde istatistiksel olarak anlamlı pozitif etkiye sahip iken, FGİD %1 anlamlılık düzeyinde öz sermaye kârlılığı üzerinde istatistiksel olarak anlamlı negatif etkiye sahiptir. Bu çalışma ile enflasyon düzeyinin bankaların öz sermaye kârlılığını nasıl etkilediği, enflasyonun istikrarlı olduğu dönemle yüksek seyrettiği dönem arasında farklılık bulunup bulunmadığı ile seçilen faktörlerin kârlılığa ne miktarda ve hangi yönde etkide bulunduğu hususunda literatüre katkı sağlayacağı değerlendirilmektedir.
Case Report : Wanita 60 Tahun dengan Vertigo Perifer di Rumah Sakit Cut Meutia Aceh Utara
Authors: Meltri Rahma Desti  , Herlina Sari
Published: January 2025

Vertigo is a phenomenon that is often encountered.  Vertigo is a symptom or feeling where someone or objects around them seem to be moving or spinning, which is usually accompanied by nausea or loss of balance. . Cases of peripheral vertigo are more common with a percentage of 75% compared to cases of central vertigo. A 60 year old woman came to the emergency room at Cut Meutia Hospital with complaints of dizziness for 3 days before entering the hospital accompanied by nausea. The results of the romber test examination showed that the patient failed to maintain balance and the dix-hallpike showed lateral nystagmus +/+. Based on the history, physical examination and supporting examinations, the patient was diagnosed with peripheral vertigo ec Benign Paroxysmal Positional Vertigo (BPPV). Medical therapy was carried out in the form of Inf. Asering, Inj. Ondancetron/12h, Betahistine 6mg 3x1, Omeprazole 20mg 2x1 and Paracetamol 500mg 3x1.
Pengaruh Efikasi Diri dan Optimisme terhadap Kecemasan pada Mahasiswa Tahun Pertama
Authors: Choirun Nisa  , Widiawati Widiawati  , Azzahra Meita Syamsyiah Putri  , Lucky Purwantini
Published: January 2025

Anxiety is an emotional reaction characterized by feelings of discomfort, tension, and concern about situations that are considered dangerous, both objectively and subjectively, which are often accompanied by physiological symptoms as well as feelings of helplessness and uncertainty without a clear cause.the subjects in this study were first-year students totaling 134 subjects who represented the population. The sampling technique used in this study was probability sampling with simple random sampling. The data collection method in this study uses psychological scales, namely the anxiety scale, self-efficacy scale, and optimism scale in Likert form. Judging from each X variable, stated self-efficacy predicts anxiety significantly while optimism cannot predict anxiety significantly. Self-efficacy and optimism have a very strong negative relationship with anxiety in first-year students at Islamic University 45 Bekasi..
Determinants Affecting Air Cargo Operational Performance in Thailand: A Strategic and Mixed-Methods Approach
Authors: Paethrangsi Nisara , Jaktong Chadaporn , Brahmaputra Parida
Published: January 2025

Background and Aims: The operational effectiveness of air cargo is a critical factor in global supply chains, as it impacts both economic growth and commerce efficiency. This study aims 1. To evaluate the impact of human, technological, cargo handling, and environmental factors on the operational efficiency of air cargo in Thailand, 2. To explore the practical insights associated with air cargo performance efficiency, and 3. To propose strategies for enhancing air cargo operational performance.
Methodology: The authors employed a sequential explanatory mixed methods approach to investigate the determinants affecting air cargo operational performance. We investigated the impact of human, technological, cargo handling, and environmental factors on the operational performance of air cargo. Quantitative data were initially gathered via a survey of 431 participants, comprising cargo operation agents, customs officers, airport managers, and cargo handling and airline personnel in Thailand. Thirteen key informants were purposefully chosen to ensure their roles and experiences were highly relevant to the air cargo industry. Criteria included five years of professional experience, and involvement in critical areas such as cargo handling, capacity management, storage, operational coordination, or regulatory compliance.
Results: It revealed significant relationships across all variables, with technological advancements exhibiting the strongest influence, followed by human factors, cargo handling processes, and environmental factors. In the subsequent qualitative phase, thematic analysis highlighted the critical role of technology including sorting technologies for loading/unloading, real-time tracking, predictive analytics such as demand forecasting, route optimization, and dynamic pricing integrating with human factors such as training, motivation, and teamwork to improve operational performance.
Conclusion: The operational efficiency of air cargo is greatly affected by the adoption of advanced technologies, the improvement of human resource management, and the optimization of cargo handling processes, while considering environmental and external factors.
A Low-Tech Assistive Tool for Inclusion of Persons with Hearing Impairments in Fiji
Authors: Ravindra Swaran , Reddy Pritika , Prasad Vineet , Sharma Bibhya , Mehta Utkal
Published: January 2025

The rapid advancements in 21st-century technology have significantly driven the development of
assistive tools, which serve as transformative aids for individuals with disabilities and emerging
bilingual learners. Despite the growing recognition of technology`s potential in education,
equitable access to these interventions for individuals with special needs remains a pressing
concern, particularly in developing countries. This study examines the challenges faced by persons who are deaf or hard of hearing in Fiji and introduces a low-tech assistive device specifically designed to address these barriers. Utilizing a two-phased survey methodology, the research explores the experiences and perceptions of individuals with hearing impairments regarding their inclusion in public spaces, government services, entertainment, and social media platforms. The second phase evaluates the efficacy of an ICT-based Sign Language Tool, developed to assist parents and educators in consistently learning and applying universal sign language. The findings reveal substantial obstacles faced by persons with hearing impairments in accessing public services, highlighting the need for tailored interventions. The study underscores the potential of simple, cost-effective, low-tech solutions to alleviate societal barriers and enhance inclusion. This baseline research lays the groundwork for the development and adaptation of targeted assistive technologies to support the inclusion of persons with disabilities in Fiji, with prospects for broader application across the South Pacific region.
ASSOCIATION OF HUSBAND SUPPORT AND POSTPARTUM BLUES IN POSTPARTUM WOMEN : SYSTEMATIC REVIEW
Authors: Nofitri Eva Rifqi , Kusumaningtyas Anggi Fitria
Published: January 2025

Background: Postpartum women have a number of difficulties in the early postpartum phase if they are not given social assistance. Programs for postpartum education are necessary to support postpartum women's mental health.
Aims: This systematic review is to review the association of husband supports and the cases of postpartum blues in postpartum women.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed, ScienceDirect and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: In the PubMed database, the results of our search brought up 350 articles, whereas the results of our search on SAGEPUB brought up 4759 articles, our search on SCIENCE DIRECT brought up 7069 articles. The results of the search conducted for the last year of 2014 yielded a total 16 articles for PubMed, 1354 articles for SAGEPUB and 2516 articles for SCIENCE DIRECT. In the end, we compiled a total of 6 papers, 2 of which came from PubMed, 1 of which came from SAGEPUB and 3 of which came from SCIENCE DIRECT. We included six research that met the criteria.
Conclusion: In summary, there is association of husband supports and the cases of postpartum blues in postpartum women. Husband involvement in prenatal care seems to be able to reduce the incidence of postpartum blues but may possibly increase the couples’ intimacy. Therefore, it can be suggested that midwives consider husband involvement in prenatal care.
Legislative history
Authors: Adderley Ian
Published: January 2025

The material in this extract is drawn from Co-operatives: Linking practice and theory (Adderley, in press). This extract provides a broad overview of legislative history from the 1850s to the early 20th century.
Pengaruh Mutasi dan Rotasi Kerja terhadap Kinerja Karyawan PT. Padang Kencana
Authors: Nisawati Inna , Rahma Elvi
Published: January 2025

Latar Belakang : Penerapapan mutasi dan rotasi kerja pada PT. Padang Kencana tidak selalu berjalan mulus sesuai dengan harapan, karena karyawan belum semua merasa nyaman dengan adanya mutasi dan rotasi kerja ini. Dan belum ada jadwal khusus untuk pergantian dan penerapan mutasi dan rotasi kerja. Tujuan: Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh signifikan Mutasi,dan Rotasi terhadap Kinerja karyawan PT. Padang Kencana cabang Jababeka II. Metodologi: Penelitian pada skripsi ini menggunakan metode kuantitatif, Sumber data yang digunakan terdiri dari data primer yaitu data yang diperoleh dari responden melalui kuesioner, wawancara, observasi populasi. Subjek dari penelitian ini adalah seluruh karyawan PT. Padang Kencana mulai dari staff, operator produksi dan driver atau supir, dengan total jumlah karyawan sebanyak 55 orang. Temuan : Hasil ini menyimpulkan bahwa hipotesis yang menyatakan Mutasi kerja mempengaruhi Kinerja karyawan, hipotesis variabel Rotasi kerja (X2) dapat mempengaruhi Kinerja karyawan, Maka Mutasi dan Rotasi Kerja berpengaruh positif dan dapat diterima. Implikasi: . Pelaksanaan rotasi dan mutasi kerja ini memberikan dampak terhadap kesiapan karyawan PT. Padang Kencana dalam melaksanakan pekerjaannya yaitu karyawan lebih banyak mendapatkan ilmu dan keahlian lainnya sehingga dapat meningkatkan kinerja karyawan. Orisinalitas: Pelaksanaan sistem rotasi kerja bagi tenaga kerja di PT. Padang Kencana – Jababeka II dilaksanakan 1 tahun sekali dengan tujuan guna menempatkan karyawan sesuai dengan kompetensi yang dimiliki.
Kata kunci: Rotasi, Mutasi kerja dan Kinerja karyawan
Alfabetización publicitaria en el aula: influencia de familiaridad y hábitat
Authors: De Frutos Torres Belinda , Pastor Rodríguez Ana
Published: January 2025

Reconocer un formato publicitario o conocer el funcionamiento de la industria publicitaria no implica alfabetización publicitaria. El trabajo pone a prueba el efecto de una intervención en el aula en la mejora de alfabetización publicitaria en función de la de la familiaridad con la fuente (influencers conocidos) y el hábitat (rural y urbano). La muestra son 62 estudiantes entre 12 y 16 años. Los resultados muestran que la intervención mejora en la identificación del contenido publicitario, de la fuente y la clasificación del contenido comercial, pero no el reconocimiento de las tácticas persuasivas. Se encuentran diferencias en el hábitat rural para identificar correctamente los contenidos publicitarios, sin embargo, no se encontraron efectos asociados a la familiaridad de los influencers. Para conseguir intervenciones eficaces es importante tener presente el contexto situacional, trabajar a lo largo del tiempo, introducir un amplio abanico de casuísticas y ahondar en las estrategias persuasivas.
actividad digital en las Stories de Instagram de los candidatos madrileños en 2023
Authors: Lava Santos David
Published: January 2025

El formato Story de Instagram se instaura como un recurso político habitual en los procesos comunicativos que tienen lugar tanto en campaña electoral como fuera de ella. Los actores políticos se apoyan en los contenidos que se pueden difundir en este nuevo entorno digital para transmitir un mensaje directo y sin intermediarios entre sus seguidores. Sin embargo, las potencialidades que ofrece este nuevo formato aún están por explorar a nivel nacional. Para arrojar luz sobre este fenómeno, la presente investigación tiene como objetivo principal analizar la actividad digital que los líderes políticos madrileños han llevado a cabo en el contenido que han difundido en sus Stories (N=329) de Instagram durante la campaña electoral celebrada en mayo de 2023, atendiendo a su agenda de temas y al discurso populista.
alfabetización publicitaria de niños y adolescentes ante los nuevos formatos digitales
Authors: Feijoo Beatriz , Núñez-Gómez Patricia , Álvarez-Flores Erika P.
Published: January 2025

La OMS advierte sobre la infodemia, el exceso de información online que afecta especialmente en redes sociales. En este entorno, diferenciar contenidos, saber identificar y seleccionar fuentes fiables y evitar la difusión de desinformación se convierte en una habilidad crucial, sobre todo entre los menores, quienes son más vulnerables. Recientes estudios sobre publicidad en medios digitales muestran que los menores a menudo no distinguen lo que es contenido de entretenimiento y contenido comercial. Esto plantea dudas sobre su preparación para enfrentarse a estos mensajes y resalta la importancia de la alfabetización publicitaria, ya que conocer qué es publicidad no garantiza una comprensión adecuada, especialmente ante contenidos donde la intencionalidad persuasiva es más sutil. Así, el pensamiento crítico resulta esencial en los programas de alfabetización, lo que supone un desafío para familias y educadores. Fomentar este pensamiento es una inversión cultural a largo plazo para formar ciudadanos conscientes, comprometidos y activos.
Publicidad y adolescencia. Estudio etnográfico de una comunidad virtual
Authors: Rodrigo-Martín Isabel , Rodrigo-Martín Luis , Muñoz-Sastre Daniel
Published: January 2025

El objeto de estudio de esta investigación consiste en conocer las principales características de los adolescentes de 12 a 16 años, estudiantes de Educación Secundaria Obligatoria, como público objetivo de diferentes campañas publicitarias. Con ese fin, se ha creado entre los estudiantes una comunidad virtual con la intención de explorar los diferentes niveles de aceptación o rechazo de las distintas cuestiones publicitarias, desde la creación de contenidos hasta la representación de la adolescencia en los formatos publicitarios. La investigación utiliza una metodología de tipo cualitativo basada principalmente en la observación de todos los participantes dentro del contexto digital en el que están inmersos y participan. Los resultados obtenidos nos van a permitir trazar una descripción minuciosa de las características, motivaciones, actitudes e inquietudes de los adolescentes y la relación que establecen con la tecnología y con la creación de contenidos.
A Retrospective Longitudinal Study: Investigate The Influence of Diabetes Mellitus on The Retears After Arthroscopic Rotator Cuff Repair
Authors: Luo Wenjie
Published: January 2025

This investigation aims to assess the impact of inadequate glycemic control on the occurrence of postoperative retear in patients diagnosed with rotator cuff pathology, with a particular focus on individuals with a pre-existing diagnosis of diabetes mellitus. A retrospective analysis was performed on a sample cohort consisting of 60 diabetic patients who had undergone arthroscopic rotator cuff repair. Glycemic control was deemed suboptimal in 32 subjects, characterized by a glycosylated hemoglobin (HbA1c) concentration ≥7.0%, while 28 subjects were identified as having effective glycemic regulation, as evidenced by HbA1c levels <7.0%. A six-month follow-up period was maintained for patient monitoring. Tendon integrity and the incidence of re-ruptures were assessed via magnetic resonance imaging (MRI), utilizing pre-established MRI criteria to identify re-tears. The employment of directed prophylactic and therapeutic measures may potentially reduce the incidence of postoperative retear events within this specific patient cohort. In the diabetic patients, effective glycemic control was associated with the better rate of healing after rotator cuff repair.
The Role of Cancer Stem Cells in Glioblastoma Treatment: New Strategies for Targeted Therapy
Authors: Yan Kaize
Published: January 2025

Glioblastoma (GBM) is a highly aggressive and recurrent brain tumor for which traditional treatments often yield limited success. According to recent research, cancer stem cells (CSCs) are essential for the development, spread, and resistance to treatment of GBM. This review systematically explores the critical roles of cancer stem cells (CSCs) in glioblastoma (GBM), especially through the regulation of Notch, Wnt, and Hh signaling pathways. The maintenance of CSC properties is primarily dependent on the Notch, Wnt, and Hedgehog (Hh) signaling pathways. This review explores the mechanisms of these pathways in GBM, discusses multi-targeted combination therapies, and highlights emerging strategies and drugs for targeted therapy. The results indicate that targeting Notch, Wnt, and Hh pathways can effectively suppress CSC proliferation and invasiveness in GBM, significantly delaying tumor recurrence. Future research should further explore the clinical potential of these pathway inhibitors and develop more specific targeted therapies to improve GBM treatment outcomes and patient prognosis.
Mechanisms and effects of aspirin to cancer cells
Authors: Wan Yiguo
Published: January 2025

Aspirin, everyone knows it is an anti-inflammatory drug, has great promise mostly for the prevention and treatment of cancer by using a number of methodologies. Its anti-cancer property come from its induction of apoptosis, inhibition of cell growth, and disruption of important signaling pathways. By exploring the mechanisms through which aspirin affects cancer cells, particularly having the impact on signaling pathways like non-coding RNAs (ncRNAs), and controlling the activity of platelets. It is also mentioned that the inhibition of cyclooxygenase (COX) enzymes is involved in aspirin’s primary action, leading to lower rate of inflammatory mediators produced and changing cellular signaling networks. The modulation of ncRNAs, especially in connection to specific cancer pathways, concentrating its role in cancer treatment for many areas. However, although huge potential of the drug exhibits, the use of aspirin is not without risks. Common symptoms such as gastrointestinal discomfort and bleeding are in considering. As all mentioned below, numerous good results in improved treatment approaches for patients will come out, follow the continued investigation into the many ways that aspirin affects cancer cells.
Application and Development of Biomimetic Solid-State Nanopore in Biosensing Technique
Authors: Ma Aorui
Published: January 2025

Biomimetic solid-state nanopore is a nano-level technology, which can be effectively used for many detection work, including DNA sequencing. The design of biomimetic solid-state nanopore is inspired by biological ion channels. Biomimetic solid-state nanopore displays many advantages. It can increase the processing characteristics while it can also ensure the performance of similar biological ion channels. It also exhibits controllable surface chemical properties, making biomimetic solid nanopores have more application space. When compared with traditional biosensors, biomimetic solid nanopores have many advantages such as low price, high sensitivity and high specificity. At the same time, biomimetic solid-state nanopores have full help for medicine, analytical chemistry, materials science, single molecule biophysics, single molecule in vitro diagnostics, and genetics. Therefore, in this work, the working mechanisms of several biosensors are introduced. In addition, the applications of nanopores in biosensing are outlined. Besides, the circuit design schemes for improving the efficiency of nanopore has been discussed. In conclusion, the help of nanopores at the single-molecule level is undoubtedly huge, and it could help mankind to understand the nanoscale world.
The Effectiveness of Learning Arabic Through Image Media for Grade VIII Students at MTs Plus Baitussalam Banyuwangi
Authors: Furoidah Asni , Rosa Amellina Julya
Published: January 2025

Arabic is a foreign language that is difficult to learn, moreover one's ability to speak Arabic is supported by good mastery of Arabic vocabulary, therefore collaboration is needed so that the process of these activities can spark the success expected by educators. Learning media is a tool or intermediary that is very appropriate for teachers to use in the process of delivering lessons to students. In other words, the application of instructional media is an effective way for educators to teach, one of which is by using media images, because in addition to helping the smooth delivery of material it also helps so that material explanations from teachers no longer use only the lecture model. The implementation of this research aims to determine the effectiveness of learning Arabic to improve the mufrodat mastery of class VIII students at MTs Plus Baitussalam Banyuwangi. The method used is a qualitative research. The results of this study prove that the use of media images can provide students' understanding, attract students' interest and encourage students' enthusiasm in learning Arabic. This identifies that the use of media images is an effective way, because it can help create an active classroom atmosphere so that students can learn optimally.
Refreshing Kader Peduli CoC (Continuity of Care) Desa Oelnasi untuk Kesehatan Ibu Hamil
Authors: Ummi Kaltsum S. Saleh  , Firda Kalzum Kiah  , Nur Susilowaty
Published: January 2025

Salah satu lingkup pelayanan posyandu yang diberikan adalah menyelenggarakan pelayanan kesehatan bagi ibu hamil, bersalin dan nifas yang sejalan dengan konsep continuity of care yaitu  serangkaian kegiatan peladenan yang berkelanjutan dan menyeluruh mulai dari kehamilan, persalinan, nifas, pelayanan bayi baru lahir serta pelayanan keluarga berencana. Kader posyandu merupakan penggerak utama seluruh kegiatan yang dilaksanakan di posyandu. Dalam kegiatan Posyandu tugas kader posyandu adalah melakukan pendaftaran, penimbangan, mencatat pelayanan ibu dan anak dalam buku KIA (Kesehatan Ibu dan Anak), menggunakan buku KIA sebagai bahan penyuluhan Refresing atau penyegaran kader perlu dilakukan secara berkala untuk meningkatkan ketrampilan dan kemandirian kader.
APPLICATION OF THE MONTE CARLO METHOD FOR THE OPTIMIZATION OF MATHEMATICAL MODEL OF SURFACE ROUGHNESS
Authors: Gredelj Sanel , Hrnjica Sanela
Published: January 2025

This paper shows optimization by using the Monte Carlo method, the mathematical model of roughness, or the mean arithmetic deviation of the profile. Optimization means finding the best of all possible solutions. According to the experiment plan, an experiment
was previously performed. Based on the results of the experiment and the plan matrix, the coefficients of the mathematical model were determined. An adequate and nonlinear mathematical model, suitable for optimization, gives the dependence of the mean arithmetic deviation of the profile from the number of main spindle revolutions, feed rate, tool diameter and cutting depth. The Monte Carlo method simulates action or proces by performing number of fictitious experiments using random numbers. The application of Monte Carlo method in optimization is not original. However, using MS Excel as a technique shown in this paper is original, reliable and simple. The disadvantage is imprecision. It is recommended to use Monte Carlo method as a control method in relation to some other method.
Dinámicas socioeconómicas y humanas en un mundo en transformación
Authors:   Universidad del Caribe, Boggio Vázquez Juan Bautista , Cervantes Bello Carmen Lilia ,   Universidad del Caribe, León Vite Elda Leticia , Mendoza	Hernández Antonio , Onofre Pérez Diego Antonio , Rizo	Amézquita José Noé
Published: January 2025

Las transformaciones productivas, tecnológicas y científicas siempre han acompañado el desarrollo de la humanidad y han estado sujetas a una notable variabilidad. Sin embargo, el mundo está cambiando a una velocidad extraordinaria, la interacción de variables económicas, sociales, geográficas e institucionales se ha acelerado produciendo nuevos modelos económicos y paradigmas productivos, así como nuevas formas de organización de la sociedad que están marcando tendencias a escala global y moldeando todos los aspectos de la vida cotidiana al difuminar las barreras entre las dimensiones física, digital y biológica. En este sentido, el objetivo de este trabajo es publicar una investigación que refleje estas novedosas dinámicas de transformación y que permita a través de las reflexiones y propuestas de los autores enriquecer los estudios en el ámbito de la economía y sociedad en un mundo cada vez más complejo. Si bien todos los capítulos muestran la interconexión de estas tendencias y riesgos, la obra se divide en tres partes: la primera aborda las tendencias de la economía mundial y los cambios de paradigma productivo; la segunda, se centra en los cambios demográficos, particularmente en la movilidad humana y su relación con el sistema capitalista; y la tercera, aborda desde una perspectiva del desarrollo humano la evolución de la seguridad social y los retos en materia de cobertura y financiamiento.
Pre- or co-activation of leg muscles is associated with risk of non-contact knee injury during a single-leg landing in badminton
Authors: Xu Yanjia , Choi Hyun-Min , Hu Zhe , Kim Sukwon , Wang Ting
Published: January 2025

Objectives: The present study evaluated if lower limb muscle pre- and co-activation was associated with the biomechanics of knee joint control during backward step single-leg landings following a badminton overhead stroke. Methods: Three-dimensional biomechanics data of the knee joint and electromyographic data of lower limb muscles were collected from 34 badminton players. Linear regression analysis of gluteus maximus, quadriceps, hamstrings, gastrocnemius pre-and muscle co-activation in relation to peak knee flexion angle, knee valgus angle and moment, peak extension moment, and tibial anterior shear force in participants 100 ms before initial touchdown were analyzed. Results: Increased quadriceps pre-activation predicts increased knee valgus angle (R2 = 0.48, P < 0.001). Greater Lateral Hamstring/Quadriceps co-contraction predicts increased peak knee extension moment (R2 = 0.39, P < 0.001). Greater lateral gastrocnemius/quadriceps co-contraction predicts an increased peak knee valgus moment (R2 = 0.20, P = 0.0073). No EMG pre-activity parameters were predictors (P > 0.05) for knee flexion angle and anterior tibial shear force. Conclusion: These findings suggested that pre-activation of the quadriceps or co-contraction ratio of the lateral hamstrings to the quadriceps or lateral gastrocnemius to the quadriceps would be positively associated with the risk of non-contact anterior cruciate ligament (ACL) injuries during a single-leg landing following a badminton backward step overhead stroke.
Impact of foreign direct investment on economic growth in developing countries: The role of institutional quality
Authors: Ghosh Surabhi , Saha Sumanta Kumar
Published: January 2025

This paper empirically examines the impact of institutional quality on FDI-driven economic growth in 135 developing countries from 1996–2020. Given that improved institutions lower business costs, reduce uncertainty, and attract FDI inflow, the study hypothesizes that enhancing institutional quality will likely foster higher economic growth in developing countries through FDI. We apply dynamic and static panel estimation techniques for this investigation. The research employs six measures of institutional quality from the World Governance Indicators (WGI) and their interaction with FDI inflow to identify key institutional quality indicators for developing countries. Results indicate a positive and significant effect of FDI on economic growth in developing countries. Moreover, enhancements in three specific institutional quality indicators—government effectiveness, regulatory quality, and the rule of law—strengthen FDI’s impact on economic growth. The study also underscores the greater significance of institutional quality in driving FDI-led economic growth in developing countries, compared to its limited impact on all countries. Ultimately, the study recommends that policymakers in developing countries devise effective strategies to enhance government effectiveness, regulatory quality, and the rule of law to expedite economic growth through FDI.
Requirements for the Development of Educational Activities in Primary School, Pedagogical Conditions and Principles of Activities to Improve the Interests of Readers
Authors: Abdukhamidova B.A. , Aidarova C.p.s. M. D. , Aktilek C.p.s. Ergeshalikyzy , Aimankul Aldash , Assel Seidamat
Published: January 2025

The article discusses the requirements and pedagogical conditions for the formation of reading competence, motivation for the art of the work, awakening, development of reading interest of primary school students.  In particular, it takes into account the fact that children will have different interests, different requirements; motivate children's interest in reading; help a child read books as a reader; distribute books among young readers; take into account the criteria and principles for selecting texts for reading; take into account the text, type of work and genre diversity; diversity of speech in texts for to use the ability to illustrate with the correct understanding of the text; the graphic and artistic quality of the recommended book for reading; the correspondence of the plot and compositional construction of the work to the age and perception of the child; adaptation of texts presented in the textbook to students of this class; the text notes that such requirements as compliance with the norm of word ratio should be taken into account. Guided by general didactic principles, it was noted that along with them there are a number of principles that should be taken into account in the activities of preparing and motivating the reader to read in the lessons of literary reading and highlighted the main points. In addition, it should be noted that there are principles of focusing attention when performing written works based on the work read, parallel reproduction of the work read with the mental activity of students with a special emphasis on the educational value of the work presented for reading. Each principle is illustrated by some examples that help the teacher's activities, regulates his activities in the field of educating the reader.
Islamophobia and International Peace: A Critical Discourse Analysis of Religious and Political Themes of Imran Khan’s Speeches at United Nations General Assembly as Prime Minister of Pakistan
Authors: Javeed Muhammad Farooq , Fayyaz Shafaq
Published: January 2025

This study critically examines Imran Khan's speeches at the United Nations General Assembly (UNGA) from 2019 to 2021, focusing on his discourse surrounding Islamophobia and its implications for international relations. Utilizing Fairclough’s three-dimensional model and Paul Gee’s seven building blocks of discourse, the research analyzes the linguistic and strategic elements of Khan's rhetoric. The findings reveal that Khan frames Islamophobia as a systematic global issue, advocating for cultural exchange and mutual understanding while countering anti-Islamic narratives. His speeches emphasize the need for recognition of Muslim rights and challenge misconceptions about Islam, portraying it as a peaceful and united faith. This analysis highlights the intersection of religious identity and political strategy in Khan's discourse, positioning Pakistan as a moral actor in the global arena. The study contributes to the understanding of how political leaders utilize language to address complex religious  and political issues and combat prejudice at international forums.
The influence of foreign debt, exchange rate and export values on Indonesia's foreign exchange reserves
Authors: Nurhasanah  , Iskandar  , Ahmad  Ridha
Published: January 2025

This research aims to determine the influence of government foreign debt, private foreign debt, exchange rate and export value on Indonesia's foreign exchange reserves. The data used in this research is secondary data by collecting data from the Central Statistics Agency and Bank Indonesia for the period 2007 to 2023. The data analysis method used in this research was multiple linear regression. Based on the results of this analysis, this research shows that partially government foreign debt and private foreign debt have a positive and significant effect on Indonesia's foreign exchange reserves, the exchange rate has a negative and significant effect on Indonesia's foreign exchange reserves and the value of exports has a positive and insignificant effect on Indonesia's foreign exchange reserves. . Meanwhile, simultaneously government foreign debt, private foreign debt, the exchange rate and the value of exports have a significant effect on Indonesia's foreign exchange reserves. The results of the coefficient of determination (R2) value show 0.926, which means that Indonesia's foreign exchange reserves are influenced by government foreign debt, private foreign debt, the exchange rate and export value by 90% while the remaining 10% is influenced by other factors not included in this research.
Inteligencia Artificial: Desafíos y Oportunidades Para Las Pymes Ecuatorianas
Authors: Jara Obregón Luis Stalin , Naspud Espinoza Mayra Gabriela
Published: January 2025

La inteligencia artificial (IA) es una tecnología emergente que ha mostrado su potencial para revolucionar la forma en que las empresas hacen negocios. Las pequeñas y medianas empresas (PYMES) en Ecuador tienen la oportunidad de beneficiarse de esta tecnología, pero también enfrentan desafíos significativos en su adopción. Uno de los mayores desafíos es la falta de conocimiento y experiencia en IA por parte de las PYMES. Además, el costo de adquirir y mantener la tecnología puede ser prohibitivo para muchas empresas. Sin embargo, existen oportunidades significativas para las PYMES que adoptan la IA. La tecnología puede ayudar a las empresas a automatizar procesos, mejorar la eficiencia y reducir costos. En este trabajo se empleó una metodología mixta que permitió el uso de datos tanto cualitativos como cuantitativos y la revisión de la literatura existente en el tema.
Hacia una Regulación Ética y Jurídica de la Maternidad Subrogada en Ecuador
Authors: Zamora Vázquez Ana Fabiola , Bravo Vintimilla Daniel Santiago , Humala Andrade Xavier Stalin , Rojas Valdivieso María Caridad
Published: January 2025

El presente trabajo estudió a la maternidad subrogada y su necesidad de regulación en la legislación ecuatoriana.  La investigación se realizó bajo un enfoque cualitativo debido a que fundamentó teóricamente esta técnica, se aplicó el método histórico – lógico al analizar los antecedentes y su evolución a lo largo de los años, además se empleó el método deductivo – inductivo por medio del estudio de conocimientos generales a particulares de la maternidad subrogada, se utilizó el método analítico – sintético al desarrollar los efectos y problemas  jurídicos que produce la falta de regulación en el Ecuador, por último se manejó el método dogmático donde se fundamentó teóricamente el tema investigado. La técnica de investigación que se utilizó fue revisión bibliográfica. Se determinó que en el Ecuador existe la necesidad de regular la maternidad subrogada para garantizar los derechos de los intervinientes; ya que esta práctica se ha venido dando de manera clandestina; adicionalmente las Técnicas de Reproducción Humana Asistida son indispensable para garantizar el derecho a la familia y es necesario una regulación urgente para ayudar a solucionar los conflictos sociales y legales de esta modalidad.
Manufactura esbelta para la mejora del proceso operacional: un caso de estudio en la industria de plástico
Authors: Espinales Meza Jacinto Daniel , Salvatierra Rogel Bryan Patricio , Vera Rodríguez Ángel José , Tigrero González Karen Antonella , Sosa Bueno Graciela Celedonia
Published: January 2025

En un entorno competitivo y de alta exigencia, Aquaplastic S.A.S., una empresa de producción de envases plásticos en Ecuador enfrenta desafíos relacionados con la generación de residuos de PVC, afectando su eficiencia operativa y sostenibilidad. Este estudio tuvo como objetivo proponer una metodología de manufactura esbelta basada en herramientas como 5S, TPM y VSM, para la mejora del proceso operacional de la empresa Aquaplastic S.A.S. La investigación utilizó un diseño no experimental de tipo transversal, recopilando datos mediante Check list, observación directa y medición de tiempos. Los resultados mostraron mejoras significativas: la herramienta 5S incrementó la organización del entorno de trabajo, pasando de un 44% a un 74%, y el TPM mejoró la Eficiencia General del Equipo (OEE) de un 68% a un 86%. La implementación redujo el tiempo de ciclo y optimizó recursos, mejorando la productividad en un 12%. Estas mejoras confirman la efectividad de las técnicas de manufactura esbelta en la optimización de procesos y la reducción de desperdicios.
Optimización del nivel de eficiencia de los eslabones de la cadena de suministro de la empacadora “Grupo Zambrano”
Authors: León Ganchozo Manuel , Navarrete Gómez Rogelio , Moposita Ortega Kelvin , Apolinario Quintana Rafael , Luna Zurita María
Published: January 2025

Este estudio tuvo como objetivo optimizar la cadena de suministro de la empacadora de banano GRUPO ZAMBRANO, abordando ineficiencias significativas que limitaban su desempeño y competitividad en el mercado agroalimentario. A través de un enfoque descriptivo y cuantitativo, se identificaron cuellos de botella y tiempos inactivos críticos en las operaciones de desflore, desmane, embalaje, repesado, aspirado y cierre de caja. El análisis de los tiempos de ciclo, estimados en 19 segundos por caja, y del Takt Time, calculado en 14.83 segundos, permitió establecer estrategias de balanceo de líneas y redistribución de estaciones de trabajo. Los ajustes realizados incrementaron la eficiencia en la producción en un 20.64% y en la distribución en un 24.6%. Además, se optimizó el número de operarios necesarios, reduciendo de 26 a 24, sin afectar la capacidad operativa. La reestructuración de las estaciones permitió alcanzar un tiempo estándar de 13.73 segundos, logrando una producción de 1945.36 cajas por turno, superando la demanda de 1800 cajas requeridas por los clientes. Este proyecto no solo resolvió las deficiencias operativas, sino que también estableció un modelo sostenible y replicable que mejora la competitividad y eficiencia en la industria bananera, posicionando a la empacadora como un referente en prácticas operativas eficientes y sostenibles.