bluuebunny/crossref_metadata_2025 huggingface dataset:
High-temperature behaviour of fluorcarletonite, KNa4Ca4Si8O18(CO3)4(F,OH)⋅H2O, from the Murun Alkaline Complex, Russia, appraised by experimental and theoretical methods
Authors: Mesto Ernesto , Lacalamita Maria , Kaneva Ekaterina , Shendrik Roman , Bogdanov Alexander , Merli Marcello , Schingaro Emanuela
Published: September 2024

The thermal behaviour of fluorcarletonite, KNa4Ca4Si8O18(CO3)4(F,OH)⋅H2O, from the charoitites of the Severny district at the Malyy Murun massif, Murun complex, NW Aldan Shield, Siberia, Russia, has been investigated in order to understand the temperature-induced changes in the crystal structure of this rare silicate. The study has been carried out combining in situ high-temperature single-crystal X-ray diffraction (T range 25–550°C), ex situ high-temperature Fourier-transform infrared spectroscopy (25–700°C) and ab initio calculations. An increasing trend of lattice parameters and cell volume was observed in the 150–550°C temperature range, when the mineral underwent a progressive dehydration process. At 550°C ~40% water loss was detected. If compared with the fluorcarletonite structure at room temperature, the partially dehydrated fluorcarletonite shows: the same space group (P4/mbm); increased distances between the oxygens of the H2O molecules (O11w and O12w) and their Na-centred octahedral cations (Na1 and Na2, respectively); distortion of the four- and six-member tetrahedral rings of the double silicate layer. The dehydration process mainly involves the oxygen at the O11w site which has a different local environment with respect to the oxygen at the O12w site. At T > 600°C, the complete dehydration is accompanied by deprotonation of the OH groups substituting for the F atoms and by the collapse of the structure when the CO2 is released. The adopted approach allowed definition of the temperature thresholds at which modifications occur in the fluorcarletonite crystal structure when subjected to controlled heating conditions. Our findings contribute to assessment of stability, reactivity and, more generally, the thermal behaviour of sheet silicates with fluorcarletonite-like topology.
Myeloid clonal hematopoiesis of indeterminate potential in patients with chronic lymphocytic leukemia
Authors: Vijenthira Abi , Volpe Virginia O. , Sekar Aswin , Santos Azevedo Roberta , Mikhaleva Mariia , Gibson Christopher J. , Martindale Stephen P. , Fardoun Rayan , Tyekucheva Svitlana , Ren Yue , Fernandes Stacey M. , Knisbacher Binyamin A. , Hahn Cynthia K. , Getz Gad , Wu Catherine J. , Davids Matthew S. , Brown Jennifer R.
Published: September 2024

Clonal hematopoiesis of indeterminate potential (CHIP) in patients with chronic lymphocytic leukemia (CLL) has not been extensively characterized. The objective of this study was to describe the prevalence of myeloid CHIP (M-CHIP) in patients with CLL, and to determine its association with time to first treatment (TTFT) and overall survival (OS). We retrospectively analyzed data from patients participating in a prospective CLL database at the Dana-Farber Cancer Institute who had standard-of-care targeted 95-gene next-generation sequencing (NGS) performed. A schema was devised to classify mutations as M-CHIP related. M-CHIP was analyzed as a binary (present/absent) and categorical (≥2 vs 1 vs 0 mutations) predictor. We included 966 patients (median age at time of NGS, 65 years; 38% female). Overall, 747 (77%) patients had NGS performed before CLL treatment, whereas 219 (23%) had it performed after receiving treatment. Median follow-up time from NGS was 1.9 years. The prevalence of M-CHIP in untreated (12%) and treated (24%) patients with CLL was similar to that described in previous literature. M-CHIP prevalence appeared to increase with age in untreated patients, but appeared consistent across age in treated patients, suggesting that treatment (85% had prior chemotherapy) may have an impact on M-CHIP emergence even in younger patients. The presence of ≥2 M-CHIP mutations was associated with OS, even accounting for prior treatment and age, but was driven by a small subset of patients (n = 28). M-CHIP was not associated with TTFT. These findings support continued work into characterizing the effects of M-CHIP in patients with CLL.
Sample size recalculation in three-stage clinical trials and its evaluation
Authors: Bokelmann Björn , Rauch Geraldine , Meis Jan , Kieser Meinhard , Herrmann Carolin
Published: September 2024

Background

In clinical trials, the determination of an adequate sample size is a challenging task, mainly due to the uncertainty about the value of the effect size and nuisance parameters. One method to deal with this uncertainty is a sample size recalculation. Thereby, an interim analysis is performed based on which the sample size for the remaining trial is adapted. With few exceptions, previous literature has only examined the potential of recalculation in two-stage trials.

Methods

In our research, we address sample size recalculation in three-stage trials, i.e. trials with two pre-planned interim analyses. We show how recalculation rules from two-stage trials can be modified to be applicable to three-stage trials. We also illustrate how a performance measure, recently suggested for two-stage trial recalculation (the conditional performance score) can be applied to evaluate recalculation rules in three-stage trials, and we describe performance evaluation in those trials from the global point of view. To assess the potential of recalculation in three-stage trials, we compare, in a simulation study, two-stage group sequential designs with three-stage group sequential designs as well as multiple three-stage designs with recalculation.

Results

While we observe a notable favorable effect in terms of power and expected sample size by using three-stage designs compared to two-stage designs, the benefits of recalculation rules appear less clear and are dependent on the performance measures applied.

Conclusions

Sample size recalculation is also applicable in three-stage designs. However, the extent to which recalculation brings benefits depends on which trial characteristics are most important to the applicants.
An ensemble machine learning model assists in the diagnosis of gastric ectopic pancreas and gastric stromal tumors
Authors: Sun Kui , Wang Ying , Shi Rongchao , Wu Siyu , Wang Ximing
Published: September 2024

Objective

To develop an ensemble machine learning (eML) model using multiphase computed tomography (MPCT) for distinguishing between gastric ectopic pancreas (GEP) and gastric stromal tumors (GIST) in lesions < 3 cm.

Methods

In this study, we retrospectively collected MPCT images from 138 patients between April 2017 and June 2023 across two centers. Cohort 1 comprised 94 patients divided into a training cohort and an internal validation cohort, while the 44 patients from Cohort 2 constituted the external validation cohort. Deep learning (DL) models were constructed based on the lesion region, and radiomics features were extracted to develop radiomics models, which were later integrated into the fusion model. Model performance was assessed through the analysis of the area under the receiver operating characteristic curve (AUROC). The diagnostic efficacy of the optimal model was compared with that of a radiologist. Additionally, the radiologist with the assistance of the eML model provides a secondary diagnosis, to assess the potential clinical value of the model.

Results

After evaluation using an external validation cohort, the radiomics model demonstrated the highest performance in the venous phase, achieving AUROC of 0.87. The DL model showed optimal performance in the non-contrast phase, with AUROC of 0.81. The eML achieved the best performance across all models, with AUROC of 0.90. The use of eML-assisted analysis resulted in a significant improvement in the junior radiologist’s accuracy, rising from 0.77 to 0.93 (p < 0.05). However, the senior radiologist’s accuracy, while improving from 0.86 to 0.95, did not exhibit a statistically significant difference.

Conclusion

eML model based on MPCT can effectively distinguish between GEPs and GISTs < 3 cm.

Critical relevance statement

The multiphase CT-based fusion model, incorporating radiomics and DL technology, proves effective in distinguishing between GEP and gastric stromal tumors, serving as a valuable tool to enhance diagnoses and offering references for clinical decision-making.

Key Points

No studies yet differentiated these tumors via radiomics or DL.

Radiomics and DL methodologies unveil potentially distinct phenotypes within lesions.

Quantitative analysis on CT for GIST and ectopic pancreas.

Ensemble learning aids accurate diagnoses, assisting treatment decisions.

Graphical Abstract
Association between laboratory markers, clinical and radiological findings in patients with idiopathic intracranial hypertension: case–control study
Authors: Fahmy Ebtesam Mohamed , Sharaf Sahar Abdelatty , Shamlol Reham Mohamed , Youssry Doaa , Elfiky Asmaa Ali , Elshebawy Haidy
Published: September 2024

Background

Idiopathic intracranial hypertension (IIH) is a disease of raised intracranial pressure. Contribution of inflammatory mediators has been suggested in IIH pathophysiology. The aim of this study was to estimate certain serum inflammatory markers in IIH patients compared to normal subjects. Also, to examine the correlation between these laboratory parameters and the clinical and radiological characteristics of IIH patients.

Results

Body mass index (BMI) was significantly higher among IIH patients compared to controls. Serum LDH, CRP, NLR and PLR were significantly higher, whereas serum iron was significantly lower in IIH patients compared to healthy controls. IIH patients with stenosis in brain MRV had significantly higher mean serum CRP compared with patients with normal MRV. There was a statistically significant positive correlation between serum CRP and the presence of stenosis in MRV, between serum LDH level and grade of papilledema, and between CRP, TIBC, and NLR with BMI.

Conclusions

There is a significant elevation of inflammatory markers in IIH patients. Moreover, cerebral venous sinus stenosis and BMI were positively associated with higher markers of inflammation as CRP, LDH and NLR indicating the role of inflammation in thrombosis and obesity associated with IIH.
Prevalence and factors associated with neck pain among research and development department staff in Bangladesh: a cross-sectional study
Authors: Chowdhury Md. Omar Sharif Ahmmed , Rasal Abu Naser Md , Huda Nurul , Islam Shahana , Khatun Most. Rumpa
Published: September 2024

Background

Neck pain is the most common musculoskeletal complexity with a high prevalence, especially in adults and the elderly.

Objectives

The objective of our study is to investigate the prevalence and associated factors of neck pain in research and development department staff in Bangladesh.

Methodology

Data were collected through questionnaire-assisted interviews to investigate the prevalence and related factors of neck pain among 384 R&D employees aged 18–55 years in Bangladesh. We performed regression analysis on neck pain and associated risk factors to uncover its sociodemographic and occupational correlates.

Results

The neck pain prevalence was high in this investigation, which is 35.7%, and of these, 27.6% affected the general working ability of the employees. The results indicated that people aged 40 to above years were more significantly to have neck pain, with an OR of 6.148 (p = 0.046), and BMI results indicated that those who were underweight were slightly significantly to have pain (p < 0.001). Again, educational qualification especially HSC or diploma OR 15.600 (p = 0.020) and those who often work on the computer were more significantly to have neck pain, with OR 8.801 (p = 0.078).

Conclusions

This study showed that the prevalence of neck pain was high among R&D workers in private industry. In this investigation, several factors associated with neck pain were found through logistic regression evaluation. The results of this study indicated that age, BMI, educational qualification, and those who frequently worked on computers had higher neck pain.
Is Support in the Anxiety of the Beholder? How Anxiety Interacts with Perceptions of Instructor Support in Introductory Biology Classes
Authors: Weatherton Maryrose , Schussler Elisabeth E. , Brigati Jennifer R. , Ferguson Hope , Boyd Isabel , England Benjamin J.
Published: September 2024

Study reveals student anxiety negatively correlates with perceived instructor support in biology classes, changing over the semester. Findings at weeks 4 and 14 show variability, suggesting targeted instructor development could aid high-anxiety students.
Effects of overconsolidation on seismic rock physics — A comparative study between unconsolidated sands and weakly cemented sandstone
Authors: Yu Jiaxin , Avseth Per , Duffaut Kenneth
Published: September 2024

In seismic rock physics, models typically assume rocks are normally consolidated, often neglecting the effects of overconsolidation. Recent studies reveal that overconsolidated sands, resulting from stress release, show different physical property variations than normally consolidated sands. However, similar research is lacking for weakly cemented sandstones, a common reservoir analog. This study aims to systematically compare the effects of overconsolidation and stress direction on unconsolidated sandstones and weakly cemented sandstones. It also assesses the impact of overconsolidation on seismic interpretation, monitoring, and rock-physics modeling applied to these two types of rocks. Experimental measurements of porosity, P-wave, and S-wave velocities were collected under different stress paths between loading and unloading. For weakly cemented sandstone, well-log data from the Norwegian Sea and Barents Sea were compared with experimental data. Analyses focused on the velocity-porosity relationship, [Formula: see text]/[Formula: see text] ratio versus AI, and [Formula: see text]/[Formula: see text] ratio versus effective stress.

Results show that overconsolidation and stress direction affect these attributes differently in both rock types. The [Formula: see text]/[Formula: see text] ratio of unconsolidated sand remains stable under stress changes, whereas weakly cemented sandstone shows significant variation. Rock-physics modeling suggests that the stress sensitivity of the [Formula: see text]/[Formula: see text] ratio in overconsolidated weakly cemented sandstone under saturated conditions depends on the extent of cement deterioration. Strong cement deterioration upon unloading increases stress sensitivity, whereas less destructive deterioration decreases it. Experimental data align with models assuming strong deterioration, whereas field data from uplifted areas fit models assuming less destructive deterioration. This work highlights the importance of considering overconsolidation in rock-physics models and reveals pitfalls in applying existing models and workflows to overconsolidated reservoir rocks.
Psychiatric evidence in immigration and asylum cases – a tale of two experts
Authors: Rix Keith
Published: September 2024

In an article in this issue ofBJPsych Advancesa courageous psychiatrist describes judicial criticism of his expert testimony in a case before the UK's Upper Tribunal (Immigration and Asylum Chamber). This commentary reflects on the value of criticism and feedback on expert witness work, contrasting the psychiatrist's positive response to the judge's words with the reaction of an expert witness in clinical negligence case, who rejected criticism of his evidence.
Preventing the risk of iatrogenic harm when assessing and diagnosing functional neurological disorders and other functional somatic symptoms
Authors: Stanghellini Giovanni , Ikkos George , Esposito Cecilia Maria
Published: September 2024

The present commentary raises some concerns about the risk of iatrogenic harm arising out of the diagnosis of functional neurologic and somatic disorders. These concerns are supported by evidence from the history of hysteria and findings from contemporary brain imaging. We discuss their implications for practice.
Pull-in features of nanoswitches in the Casimir regime with account of contact repulsion
Authors: Klimchitskaya G. L. , Korotkov A. S. , Loboda V. V. , Mostepanenko V. M.
Published: September 2024

The cantilever tip of a nanoswitch in close proximity to the ground plate is considered with account of electrostatic, elastic, van der Waals (Casimir), and also contact repulsive forces. The van der Waals (Casimir) and contact repulsive forces are computed for a Si cantilever and either Au or Ni ground plates using the Lifshitz theory and the method of pairwise summation with account of surface roughness. It is shown that at short separations an impact of the van der Waals (Casimir) force leads to the pull-in and collapse of a cantilever onto the ground plate if the contact repulsion is disregarded. Taking into consideration contact repulsion, the nanoswitch is demonstrated to have the stable cyclic behavior with no pull-in when switching voltage on and off.
Bistability in the sunspot cycle
Authors: Vashishtha Sumit , Sreenivasan Katepalli R.
Published: September 2024

A direct dynamical test of the sunspot cycle is carried out to indicate that a stochastically forced nonlinear oscillator characterizes its dynamics. The sunspot series is then decomposed into its eigen time-delay coordinates. The relevant analysis reveals that the sunspot series exhibits bistability, with the possibility of modeling the solar cycle as a stochastically and periodically forced bistable oscillator, accounting for poloidal and toroidal modes of the solar magnetic field. Such a representation enables us to conjecture stochastic resonance as the key mechanism in amplifying the planetary influence on the Sun, and that extreme events, due to turbulent convection noise inside the Sun, dictate crucial phases of the sunspot cycle, such as the Maunder minimum.
Non-Aristotelian Elements in Carl Menger's Methodology
Authors: Slenzok Norbert , Turowski Krzysztof
Published: September 2024

According to the dominant interpretation, Carl Menger, the founder of the Austrian school, was an Aristotelian methodologist of social science. As this article attempts to demonstrate, this influence was not decisive in shaping Menger's methodology. In fact, Menger shared several core positions with modern thinkers. Such non-Aristotelian threads in Menger tackled in the article encompass his views on essentialism and realism, a priori knowledge, the classification of sciences, and scientific value-freedom, as well as methods of historical inquiry. As is shown, while unattachable to any specific philosophical school, those five elements constitute a fairly consistent, non-Aristotelian account of economic methodology.
Chartalism in Ancient China: A Retrospective of Monetary Thought
Authors: He Zengping
Published: September 2024

Chartalism is an influential and continuous tradition of monetary thought in ancient China. It dates back to the earliest Chinese text on monetary thought and continued into the Qing Dynasty. A vast body of related literature can be found across ancient Chinese dynasties. Chartalism in ancient China had the following main propositions. First, money originated as an invention of ancient monarchs and is a creature of the state. The second is the nominal theory of money: useless metal can function as money and become a tool of state intervention in the economy through state support. Third, the right to issue money should be monopolized by the state; otherwise, the state's monetary policy will be interfered with by other currencies. Fourth, an important monetary policy is the government's buying and selling of commodities countercyclically by issuing and receiving money, thus stabilizing prices. Fifth, the circulation process of sovereign money consists of two parts: the state's minting of coins (or issuing of paper money) and spending are the outflow of money, and levying monetary taxes (or selling goods) is the inflow of money. The state stabilizes the value of money by intervening in the circulation process.
Cingulin–nonmuscle myosin interaction plays a role in epithelial morphogenesis and cingulin nanoscale organization
Authors: Rouaud Florian , Maupérin Marine , Mutero-Maeda Annick , Citi Sandra
Published: September 2024

Cingulin (CGN) tethers nonmuscle myosin 2B (NM2B; heavy chain encoded by MYH10) to tight junctions (TJs) to modulate junctional and apical cortex mechanics. Here, we studied the role of the CGN–nonmuscle myosin 2 (NM2) interaction in epithelial morphogenesis and nanoscale organization of CGN by expressing wild-type and mutant CGN constructs in CGN-knockout Madin–Darby canine kidney (MDCK) epithelial cells. We show that the NM2-binding region of CGN is required to promote normal cyst morphogenesis of MDCK cells grown in three dimensions and to maintain the C-terminus of CGN in a distal position with respect to the ZO-2 (or TJP2)-containing TJ submembrane region, whereas the N-terminus of CGN is localized more proximal to the TJ membrane. We also show that the CGN mutant protein that causes deafness in human and mouse models is localized at TJs but does not bind to NM2B, resulting in decreased TJ membrane tortuosity. These results indicate that the interaction between CGN and NM2B regulates epithelial tissue morphogenesis and nanoscale organization of CGN and suggest that CGN regulates the auditory function of hair cells by organizing the actomyosin cytoskeleton to modulate the mechanics of the apical and junctional cortex.
An improved tetracycline-inducible expression system for fission yeast
Authors: Lyu Xiao-Hui , Yang Yu-Sheng , Pan Zhao-Qian , Ning Shao-Kai , Suo Fang , Du Li-Lin
Published: September 2024

The ability to manipulate gene expression is valuable for elucidating gene function. In the fission yeast Schizosaccharomyces pombe, the most widely used regulatable expression system is the nmt1 promoter and its two attenuated variants. However, these promoters have limitations, including a long lag, incompatibility with rich media and unsuitability for non-dividing cells. Here, we present a tetracycline-inducible system free of these shortcomings. Our system features the enotetS promoter, which achieves a similar induced level and a higher induction ratio compared to the nmt1 promoter, without exhibiting a lag. Additionally, our system includes four weakened enotetS variants, offering an expression range similar to that of the nmt1 series promoters but with more intermediate levels. To enhance usability, each promoter is combined with a Tet-repressor-expressing cassette in an integration plasmid. Importantly, our system can be used in non-dividing cells, enabling the development of a synchronous meiosis induction method with high spore viability. Moreover, our system allows for the shutdown of gene expression and the generation of conditional loss-of-function mutants. This system provides a versatile and powerful tool for manipulating gene expression in fission yeast.
Do seabirds dream of artificial lights? Understanding light preferences of Procellariiformes
Authors: Atchoi Elizabeth , Mitkus Mindaugas , Machado Biana , Medeiros Valter , Garcia Sofia , Juliano Manuela , Bried Joël , Rodríguez Airam
Published: September 2024

Seabirds, and particularly fledglings of burrow-nesting species, are greatly impacted by light pollution. During their inaugural flights from colony to sea, fledglings become grounded after encountering artificial light. Such groundings, or fallout events, affect many fledglings each year, causing mass mortality events. To mitigate this light-induced mortality, rescue programmes have been implemented for decades at many locations worldwide. Despite the notoriety of fallouts and their conservation implications, the contributing behavioural and biological factors remain mostly unknown. How the mechanisms of light attraction and light avoidance interact and how they manifest in different groups (e.g. age, personality, populations) or light pollution levels remain open questions. We tested behavioural choices of Cory's shearwater Calonectris borealis fledglings, rescued after being grounded in urban areas, and choices of breeding adults for contrasting light sources. Fledglings and adults were exposed to one of three treatments in an experimental Y-maze set-up: white light versus no light, blue versus red light, and a control with no light on each arm of the Y-maze. Both age groups clearly chose the no-light arms and the red light arm. This choice for longer wavelengths and darker environments, along with slower responses by fledglings, suggests that close range artificial light causes disorientation in seabirds. Our study helps to clarify the behavioural components of fallouts and provides further evidence on the disruptive effects of nocturnal artificial light on sensitive species like Procellariiformes.
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in bacterial infections: contributions to diagnostic strategies in a tertiary care hospital in Tunisia
Authors: Anoun Jihed , Ajmi Mariem , Riahi Salma , Dhaha Yosra , Mbarki Donia , ben Hassine Imen , Romdhane Wiem , Baya Wafa , Adaily Najah , Mzabi Anis , Ben Fredj Fatma , Bouattay Amina
Published: September 2024

Background Bacterial infections continue to pose a global health challenge, driven by antibiotic resistance and septicemia. This study aimed to assess the diagnostic utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in bacterial infections versus non-infectious causes of inflammation. Methods A prospective study included 164 adult patients who were divided into two groups: a group of patients with confirmed bacterial infections and a second group of patients with other diagnoses (inflammatory pathologies, neoplasms, venous thromboembolic diseases, etc.). NLR and PLR values were compared between the bacterial infection group and the non-infectious causes group and the diagnostic performances of NLR and PLR for detecting bacterial infections were evaluated in comparison with other infection markers. Results NLR and PLR were significantly higher in bacterial infections (p < 10^-6), and NLR was correlated positively with inflammation markers. NLR and PLR demonstrated significant potential in diagnosing bacterial infections, with an AUC of 0.72 and 0.60, respectively, using the following cutoff values: 4.3 for NLR and 183 for PLR. Conclusion These findings underscore the importance of NLR and PLR as adjunctive tools for bacterial infection diagnosis.
The genome sequence of the Brindled Ochre moth, Dasypolia templi (Thunberg, 1792)
Authors: Griffiths Andy ,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: September 2024

We present a genome assembly from an individual male Brindled Ochre moth, Dasypolia templi (Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence has a total length of 855.30 megabases. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.37 kilobases in length.
The Role of Personal Resources and the Results of External Exams in Explaining School Achievements of High School Students
Authors: Ciżkowicz Barbara
Published: September 2024

Badanie miało na celu określenie znaczenia zasobów osobistych takich, jak samoocena, poczucie własnej skuteczności, motywacja do uczenia się i poczucie bezradności oraz wyników egzaminu zewnętrznego poprzedzającego naukę w szkole średniej w wyjaśnianiu osiągnięć szkolnych uczniów szkół średnich. Próba składała się z 489 uczniów trzecich klas szkoły średniej, w tym 220 licealistów, 161 uczniów techników i 108 zasadniczych szkół zawodowych.  Hierarchiczna analiza regresji wskazała, że zasoby osobiste i typ szkoły były istotnymi predyktorami osiągnięć szkolnych (R2 = .279). Najważniejszym z nich była motywacja (β =.325). Potwierdzono też pośredniczącą rolę motywacji, poczucia skuteczności i poczucia bezradności w związku między samooceną a osiągnięciami szkolnymi (PROCESS macro). Dodanie do modelu wyników egzaminów zewnętrznych poprawiło znacząco jego jakość. Modelowanie równań strukturalnych potwierdziło dobre dopasowanie modelu (χ2 = 62.20, df = 18, p < .001; CFI = .974; TLI = .946; SRMR = .033; RMSEA = .071). Model wyjaśnił ponad połowę (R2 = .617) zmienności osiągnięć szkolnych uczniów szkół średnich.
Pembrolizumab in combination with FOLFIRINOX for treatment of advanced pancreatic adenocarcinoma with MSI-H
Authors: Singh Ashmin , Sanghavi Nairuti , Bandari Vandana , Khan Iftekhar , Alfaraj Abeer
Published: September 2024

Pancreatic cancer is one of the four most common causes of cancer-related death in the United States. Our patient had metastatic pancreatic cancer with a high tumour burden. He was trialled on an unconventional treatment of combination immunotherapy and chemotherapy. It resulted in decreased cancer burden and decreased FDG activity on a PET scan. Further studies are needed for standard pancreatic cancer treatment.
The role of standardized quality systems in the management of a healthcare provider
Authors: Żuraw Daria , Oleksa Paulina , Sobczyk Mateusz , Jasiński Kacper , Porzak Mikołaj , Sodolska Alicja , Żybowska Monika , Rzewuska-Fijałkowska Anna
Published: September 2024

Review Article, Pol J Public Health, Vol. 134 (2024): 69-72

Daria Żuraw, Paulina Oleksa, Mateusz Sobczyk, Kacper Jasiński, Mikołaj Porzak, Alicja Sodolska, Monika Żybowska, Anna Rzewuska-Fijałkowska
Student Scientific Association at the Chair and Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, Poland

DOI_disc_logo 10.12923/2083-4829/2024-0015

© 2024 Author(s). This is an open access article distributed under the Creative Commons Attribution-NonComercial-No Derivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/)

Abstract
Since the 1940s, the healthcare sector in Poland has been in constant evolution and requires constant improvement in the quality of services provided and customer-patient satisfaction. To facilitate quality management, systems dedicated to healthcare entities have been developed over the years, and others have been adapted to medical facilities. These methods are based on efficient, planned, repeatable, documented procedures based on current medical knowledge. The key is to choose the right system, tailored to the way the entity operates. A quality management system defines: organizational structure, available resources, procedures and processes to be implemented, the way information and documents communicate and flow, and the responsibility for quality assurance care and compliance. Creating awareness and a pro-quality attitude in the field of medical services makes it possible to learn about instruments and solutions aimed directly at healthcare provider, as well as those that can be adapted and subsequently implemented.

Keywords: ISO standards, accreditation standards, total quality management, adverse events, medical mistake, management.
The impact of preparing food in aluminum cookware on human health – a literature review
Authors: Przybysz Bartosz , Smalira Joanna , Lęgas Angelina , Rogala Weronika , Pochodowicz Katarzyna , Rogowska Karolina , Zawistowska Julia , Kawalec Jakub , Rutkowska-Kawalec Weronika , Mormul Agata
Published: September 2024

Introduction. Aluminum is an element commonly found in the environment. It is used in various industrial sectors, for example as a manufacturing material for food-grade utensils.

Aim. The aim of this scientific paper is to answer to the question of whether people expose their health to the harmful effects of aluminum by utilising these types of items for preparing and storing food.

Description of the state of knowledge. Aluminum has a proven noxious impact on the human body. Due to its neurotoxic properties, it may induce clinical symptoms. Excessive exposure to this element is also associated with the occurrence of bladder and lung cancer, while the connection with breast tumours remains debatable. Additionally, aluminum can be harmful to our health, as a component of some medical preparations.

Conclusions. It is crucial to emphasise the necessity of complying with the amounts of
aluminum consumption recommended by international institutions. Short-term use of aluminum pots does not pose a threat to our well-being. Also, long-term usage in most cases does not lead to exceeding the aluminum consumption standards, although children may be at risk. However, it is good practice to avoid cooking acidic products in aluminum utensils. Furthermore, it is worth washing the dishes according to the manufacturers’ recommendations and replacing them with new ones every few years. In addition, some scientists suggest choosing pots made of different materials, e.g. titanium. Moreover, a noticeable decrease in the levels of vitamin B1 and C in food prepared in aluminum dishes may be one of the reasons for their lower nutritional value, however this issue should be examined further.

Keywords: aluminum; cooking and eating utensils; food safety; neurotoxicity.
Peculiarities of information aggression influence on different categories of the population
Authors:   State Institution Luhansk Taras Shevchenko National University, Kurylo Vitalii , Karaman Olena ,   State Institution Luhansk Taras Shevchenko National University, Stepanenko Viktoriia ,   State Institution Luhansk Taras Shevchenko National University
Published: September 2024

The article states that the impact of russia’s information aggression against Ukraine is multi-level and includes many factors aimed at weakening Ukraine in political, military, economic, informational, social and other aspects. Human psyche and consciousness, as well as collective and mass consciousness, are considered as the main channel of such influence. It is emphasized that information influence, on the one hand, is characterized by global reach, and on the other hand, it can be differentiated in terms of content, style and forms depending on the target audience. Within the framework of the appropriate approach, the differentiation of the impact of russian information aggression on the population, proposed by the National Institute of Strategic Studies, is presented: the influence on the population of the russian federation itself, the influence on the population of the annexed, temporarily occupied territories of Ukraine and the territories that are directly in the war zone; the influence on the population of Ukraine as a whole; the influence on the population of other countries, international organizations, and the world community. The specifics of the influence of information aggression on society are also determined, based on the theory of algorithms; in the context of cognitive, gender and other approaches. It is noted that the segmentation of the information aggression influence on different categories of the population can be based on different approaches, taking into account such parameters as age, social status, gender, level of education, geographical indicators, belonging to social or political groups, etc.
Theoretical foundations of the formation of social cohesion at the level of the territorial community
Authors:   State Institution Luhansk Taras Shevchenko National University, Otroshchenko Nataliia
Published: September 2024

The article emphasizes that the social cohesion of the territorial community is one of the fundamental values that ensures its effective development and is of crucial importance for the well-being of people and the community. It is emphasized that the current stage of social cohesion research in science is focused on the wide use of an interdisciplinary approach. Local identity is characterized as one that allows a person who identifies with the local community to form a sense of involvement in events and situations occurring in the territory of immediate residence (cities, towns, villages). Some key ideas about what social cohesion is and why it is important are outlined, including how social cohesion can be strengthened through various means, such as investment in education, promoting social inclusion and supporting community-led initiatives. It is summarized that traditional factors contributing to the formation of social cohesion are external or internal challenges. Under the condition of a positive direction of events, the influence of these factors contributes to the development of patriotism, the formation of a sense of national identity, the sense of security of citizens, the construction of an inclusive space, a high level of trust in the authorities and social institutions.
ABA-therapy as a modern technology of correctional work with children with ASD (advantages and disadvantages)
Authors:   State Institution Luhansk Taras Shevchenko National University, Yarmoliuk Oksana
Published: September 2024

The article deals with the essence, content, stages, advantages and disadvantages of the extremely popular among parents technology of corrective influence on children with ASD – ABA therapy, which is aimed at forming the necessary skills in a child that are absent due to developmental disorders. It has been determined that this approach can be used to solve a range of different tasks: the development of skills that can replace undesirable forms of behavior; the development of social and communication skills, such as maintaining eye contact, understanding the interlocutor’s facial expressions, the ability to ask for help, ask questions, play with other children; the development of academic skills (reading, arithmetic, writing) at a level accessible to the child; the development of household and self-care skills: independent toilet use, cooking and. Despite the fact that in the modern world ABA therapy is a scientifically proven and widespread method that has found its application in various areas of education and support for children with various developmental disorders, it has a number of significant drawbacks: The technique is ineffective if the child is afraid of strangers; the technique works only if it is used correctly and implemented by ABA therapists; breaks in classes or a reduction in their duration can affect the result; parents should take an active part in the work and, with the help of a specialist, organize a correct developmental system at home; children with ASD often have little effect on encouragement, it is important to understand what reward the child needs to get the desired result.
Psychological and pedagogical aspects of the development of drawings of older preschoolers by means of music
Authors:   SHEE ", Dronova Olha ,   Donbas State Pedagogical University"
Published: September 2024

The article is devoted to highlighting the psychological and pedagogical aspects of the problem of the development of drawings of 5–6-year-old children by means of music. The presented content is the result of experimental pedagogical research, which proves the hypothesis that the use of music in the pedagogical process contributes to the child’s interest in drawing, the development of his/her visual thinking and artistic imagination, the emergence of the creative idea of the drawing and the enrichment of its content, affects the expressiveness and general aesthetics of the drawing. The psychological aspect of the development of drawings consists of creating conditions and helping the educator to develop the child’s artistic attitude to the perception of a musical piece, interest, and readiness for image creation, creating an imaginary image, and the desire to visualize it by means of painting. The pedagogical aspect consists of the development and substantiation of pedagogical conditions for the development of a drawing by means of music. These are defined as follows: training of future educators and self-education of educators in the field of musical art, competence in the field of image formation of older preschoolers; adequate selection of musical works; selection and justification of forms of pedagogical work, methods of interaction, visual tasks, etc. The main pedagogical condition is the educator’s willingness to help the child develop the ability to transfer imaginary images inspired by musical accompaniment into a picture. Music, adequately involved in the pedagogical process, contributes to the development of the child’s emotional sphere, awakens creative imagination, and creates space for the development of his/ her visual thinking. The child’s experience of perceiving music in images, combined with the experience of artistic and aesthetic self-expression and creative invention in the search for image methods and expressive means of painting, has a positive effect on the content and expressiveness of his/her drawings. The drawing develops from a scheme to an original artistic image.
Studying contemporary children's literature in primary school classes of the New Ukrainian School
Authors:   State Institution Luhansk Taras Shevchenko National University, Pushko Vira , Pravova Ninel ,   State Institution Luhansk Taras Shevchenko National University
Published: September 2024

The article actualizes the problem of literary education in the context of the implementation of the ideas of the New Ukrainian School. The content of the linguistic and literary educational field of the typical educational programs of the NUS on the topics of contemporary children's literature recommended for study by younger students is considered. The current textbooks on Ukrainian language and reading for grades 2–4 are analyzed in terms of their content with texts by contemporary children's writers; genre and thematic varieties of literature presented for study by primary school students are outlined. It is proved that, compared to the previous ones, the new textbooks are supplemented with contemporary Ukrainian works of children's literature. Instead, there are works whose content, themes, artistic images, characters are incomprehensible to students, do not correspond to their life, reading, emotional and sensory experience. It has been determined that the percentage of fiction texts by contemporary writers of the twenty-first century in textbooks for junior pupils is too small. The compilers do not pay attention to works on psychological topics, on the relationship between children and parents, on the heroes of Ukraine, and on the problems of «children of war».
Methodical capabilities of the nanoHUB service when studying the topic “Biosensors”
Authors:   State Institution Luhansk Taras Shevchenko National University, Bondarenko Lina , Kuriachyi Yevhen ,   State Institution Luhansk Taras Shevchenko National University
Published: September 2024

The paper describes the unique online resource nanoHUB, which offers a wide range of tools and materials for the study of biosensors. The benefits of nanoHUB for improving the educational process and scientific research in this field are discussed, including access to relevant materials, interactive learning, support for independent learning, promotion of collaboration, and the possibility of integration into educational programs. The interactive tools, ease of use and systematic approach to learning offered by the platform were analyzed. Special attention is paid to specialized tools for modeling and analysis of biosensors, which allows students to gain a deeper understanding and visualization of the processes that occur in biosensors. The article emphasizes the importance of nanoHUB as a resource that contributes to the improvement of the quality of education and the development of scientific research in this area.
The role of digital competence in the professional development of future psychologists
Authors:   State Institution Luhansk Taras Shevchenko National University, Tovstukha Olesia , Chumak Olha ,   State Institution Luhansk Taras Shevchenko National University
Published: September 2024

The scientific article is devoted to the issue of determining the role of digital competence in the professional development of future psychologists. It was determined that modern society is developing in conditions of digital transformation, which qualitatively changes the functioning of social institutions and people’s lives. Information technologies have become a necessary and most important element in many spheres of human activity, including professional ones. For the successful performance of work functions, a modern psychologist needs to possess basic professional competencies, among which an important place is occupied by digital competencies, by which we understand the ability of an individual to confidently and thoroughly use the means of digital technologies in such areas as professional activities and employment, leisure, which are vital for participation in daily socio-economic life. The formation of digital competence of future psychologists is possible due to the expansion of forms of education, namely the use of interactive lectures, lectures-visualizations, lectures with pre-planned errors, during which students of higher education get acquainted with the principles of using digital technologies in the professional activity of a psychologist; during practicums and performing laboratory work, researching the peculiarities of working with artificial intelligence platforms and modern digital tools for organizing joint activities with clients; familiarization with the databases of psychological research on the sites of scientific journals on psychological topics, which are indexed in the international scientometrics databases Scopus, Web of Science, Index Copernicus; thanks to the analysis of blogs, social networks, various streams of information messages, future psychologists can familiarize themselves with the features of running their own blog, and in the future create their own page, etc.
Identification of individual qualities of first bachelor's level education seekers, necessary for future animation activities in the field of physical education and sports
Authors:   State Institution Luhansk Taras Shevchenko National University, Omelchenko Alina
Published: September 2024

The article is devoted to the problem of quality training of specialists in the field of sports animation. The article analyzes the essence and content of animation activity in modern conditions of the development of society. The role of leisure, recreation, rest and activity in the life of modern youth is revealed. The article establishes that the term sports animation means innovative activity in the field of physical education and sports, in which participants of different age and social groups are involved in active, creative interpersonal relationships. It is noted that the main difference between sports animation and tourist animation is the active involvement of participants in sports activities using various equipment and competitive methods. To reveal the topic of the article, we organized and conducted a pedagogical study aimed at identifying the individual qualities of first bachelor’s level education seekers, necessary for future animation activities in the field of physical education and sports. In the process of research, several tests were conducted with students to identify the level of culture of pedagogical communication; development of communication skills and abilities; the level of development of mime and pantomime expressiveness; physical development; the level of psycho-emotional stability and a survey to reveal their personal opinion on the issue of the necessary individual qualities of a sports animator. The results of pedagogical research are highlighted in the article with the help of tables and diagrams. These data can be used in the process of training students in higher educational institutions.