bluuebunny/crossref_metadata_2025 huggingface dataset:
Forecasting China carbon price using a error corrected secondary decomposition hybrid model integrated fuzzy dispersion entropy and deep learning paradigm
Authors: Yun Po , Zhou Yingtong , Liu Chenghui , Wu Yaqi , Pan Di
Published: November 2023

To promote the market-oriented mechanism in carbon emission reduction, improve the role of carbon price forecasting in guiding investors to make quantitative investments, this paper constructs a error corrected carbon price forecasting model integrated fuzzy dispersion entropy and deep learning paradigm, namely, ICEEMDAN-FDE-VMD-PSO-LSTM-EC. Initially, the ICEEDMAN is used to primary decompose the original carbon price. Subsequently, the fuzzy dispersion entropy is conducted to identify the high-complexity signal after the primary decomposition. Thirdly, the VMD and deep learning paradigm of LSTM optimized by the PSO algorithm are employed to secondary decompose the high complexity signals and perform the out-of-sample forecasting. Finally, the error corrected (EC) method is conducted to re-modify the above predicted results to improve the forecasting accuracy. The results conclude that the forecasting performance of the ICEEMDAN-type secondary decomposition models are significantly better than the primary decomposition models, the deep learning PSO-LSTM-type models have superiority in forecasting China carbon price, the error corrected method for improving the forecasting accuracy has achieve satisfactory results. Noteworthy, the proposed model has the best forecasting accuracy, with the forecasting errors RMSE, MAE, RMSE and Pearson correction are 0.0877, 0.0407, 0.0009 and 0.9998. Especially, the long-term forecasting performance for 750 consecutive trading price is outstanding. Those conclusions contribute to judge the carbon price characteristics and formulate market regulations.
Site- and enantioselective B−H functionalization of carboranes
Authors: Lee Phil Ho , Lee Kyungsup , González-Montiel Gisela , Eom Hyeonsik , Kim Tae Hyeon , Noh Hee Chan , Farah Abdikani , Wise Henry , Kim Dongwook , Cheong Paul
Published: November 2023

Functionalization of carboranes, icosahedral boron − carbon molecular clusters, is of great interest as they have wide applications in medicinal and materials chemistry. Thus, site- and enantioselective synthesis of carboranes requires complete control of the reaction. Herein, we describe the first asymmetric Rh(II)-catalyzed insertion reactions of carbenes into cage B − H bond of carboranes. This reaction thereby generates carboranes possessing a carbon-stereocenter adjacent to cage boron of the carborane, in excellent site- and enantioselectivity under mild reaction conditions. The first fully computed transition structures of Rh(II)-catalyzed carbene insertion process through density functional theory are reported. These B − H insertion transition structures, in conjunction with newly employed topographical proximity surfaces analyses, visually reveal the region between the carborane and the phthalimide ligands responsible for the selectivities of this reaction.
Causal associations of mental health disorders with aortic and peripheral vascular disease: a bi-directional two- sample mendelian randomization study
Authors: Peng Minyong , Nie Chengli , Li Chao , Yang Rui , Ran Pan , Peng Qian , Hu Jie
Published: November 2023

Background
The actual causality between mental health disorders (MHD) with aorta and peripheral vascular disease (APVD) has not been established for the limited researches and the potential confounding factors.
Methods
Bi-directional two-sample Mendelian randomization (MR) analysis was performed to investigate evidence of causality and direction of 4 MHD (schizophrenia, anxiety disorder (AD), bipolar disorder (BD), and major depression disorder (MDD)) with 18 common APVD. Summary-level genetic statistics for MHD were obtained from Psychiatric Genomics Consortium, and APVD from FinnGen Project database. The inverse-variance weighted method was used for the primary MR analyses. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests.
Results
Genetically-predicted schizophrenia was associated with increased risk of varicose veins [Odds Ratio (OR): 1.05; 95%confidential interval (CI): 1.01 to 1.09, P = 0.02], congenital malformations of heart and great artery (OR: 1.07; 95%CI: 1.00 to 1.14, P = 0.04), haemangioma and lymphangioma (OR: 1.12; 95%CI: 1.03 to 1.21, P = 0.01), and haemangioma (OR: 1.12; 95%CI: 1.03 to 1.22, P = 0.01). Genetically-predicted MDD was associated with reduced risk of varicose veins (OR: 0.87; 95%CI: 0.78 to 0.96, P = 0.01), giant cell arteritis (OR: 0.59; 95%CI: 0.36 to 0.97, P = 0.04), haemangioma and lymphangioma (OR: 0.71; 95%CI: 0.52 to 0.97, P = 0.03), and haemangioma (OR: 0.70; 95%CI: 0.50 to 0.98, P = 0.04), with an increased risk of pulmonary embolism (OR: 1.21; 95%CI: 1.02 to 1.45, P = 0.03). No significant association was observed for AD or BD. Evidence from bidirectional MR did not support reverse causality.
Conclusion
This study report evidence in support of potential causal associations of schizophrenia and MDD with several APVD. Further studies are needed to validate the findings and investigate potential mechanisms.
The Physical Evaluation and Adverse outcomes for patients with chronic Kidney disease in Guangdong (PEAKING) project: a protocol and overview for a prospective cohort study
Authors: Yang Changyuan , Duan Ruolan , Yang Zhenhua , Qiu Jiamei , Pi Minhui , Ling Xitao , Xiao Cuixia , Zeng Jiahao , He Jiawei , Huang Jiasheng , Zhang La , Qin Xindong , Tang Fang , Fu Lizhe , Hou Haijing , Liu Xusheng , Lindholm Bengt , Lu Fuhua , Wu Yifan , Su Guobin
Published: November 2023

Introduction:
Physical inactivity is prevalent and associated with adverse outcomes among patients with chronic kidney disease (CKD). Most previous studies have relied on subjective questionnaires to assess levels of physical activity (PA), and mainly focused on patients on dialysis. Therefore, the PEAKING study aims to investigate the levels and types of PA such as traditional Chinese exercise (TCE) and their association with adverse outcomes in Chinese non-dialysis CKD (ND-CKD) stage 3–5 patients.
Methods and analysis:
In this prospective cohort study, 374 ND-CKD stage 3–5 patients will be recruited in Guangdong province, South China. The primary exposure is levels of PA assessed by Actigraph GT3X + accelerometer including the intensity, duration, frequency, and types of PA. The primary outcomes are all-cause mortality and all-cause hospitalization. Other variables include demographics, comorbidities, medication, laboratory markers etc,. will be collected. All data will be updated annually for 5 years, or until the occurrence of death or initiation of renal replacement therapy.
Preliminary results:
Among 104 patients (57 ± 14 years; men 57%) with ND-CKD stage3-5 enrolled so far [stage 3 (55.8%), stage 4 (22.1%), and stage 5 (22.1%)], more than half of them (n = 62) achieveed at least 150 minutes of moderate-intensity PA per week and slightly outnumbered non-achievers (n = 42), indicating a relatively balanced distribution.
Conclusions
In this the first investigation of the relationship between exposure to PA including TCE and outcomes, the feasibility of the study including collection of data according to protocol was confirmed.
Exploring the Physical, Chemical, and Biological Properties of Soils from Different Regions Classified into Different Textural Classes
Authors: Saba Mohammed , Karaca Ummahan Çetin
Published: November 2023

Soil is a living, dynamic structure that plays critical roles in terrestrial ecosystems. Soil texture is an important soil property because it influences other important soil qualities such as soil structure, soil moisture, the diversity of living organisms, plant growth, and overall soil quality. Soil texture has an impact on the chemical and physical qualities of the soil, as well as enzyme activity and microbial population. The study's goal was to look into the chemical characteristics, soil enzymes, and soil respiration of soils with various textures (sandy loam, clay loam, clay, sandy clay loam). Soil samples were collected from eight distinct regions (Kücükkoy, Fethiye, Dinlendik, İçer Çumra, Kuzucu, İnli, Alibeyhüyüğü, and Güvercinlik) at depths ranging from 0 to 30 cm in Konya's Cumra district, and four different texture classes were determined. Soil texture has been shown to have different impacts on pH, EC, lime, organic matter, macro and micro components, soil respiration, and various enzyme activities. These textural alterations resulted in statistically significant differences. Variations in these factors were also shown to change the action of specific soil enzymes. The results also show that clay-textured soil has the highest amounts of microelements, soil respiration, catalase, acid, and alkaline phosphatase enzyme activity.
The MRI-based Vertebral Bone Quality Score is a Predictor of Pedicle Screw Loosening Following Instrumented Posterior Lumbar Fusion
Authors: Hu Yung-Hsueh , Chou Jian-Hong , Yeh Yu-Cheng , Hsieh Ming-Kai , Tsai Tsung-Ting , Chen Wen-Jer , Chen Lih-Hui , Lai Po-Liang , Niu Chi-Chien
Published: November 2023

Objective:
To investigate the predictive ability of the MRI-based vertebral bone quality (VBQ) score for pedicle screw loosening following instrumented transforaminal lumbar interbody fusion (TLIF).
Methods:
Data from patients who have received one or two-level instrumented TLIF from February 2014 to March 2015 were retrospectively collected. Pedicle screw loosening was diagnosed when the radiolucent zone around the screw exceeded 1mm in plain radiographs. The T1-weighted MRI sagittal images were used for calculation of the VBQ score. Univariate analysis and multivariate binary logistic regression analysis were performed. Receiver operating characteristic curve analysis assessed the predictive ability of the VBQ score on screw loosening.
Results:
Among the included 211 patients, 75 of them (35.55%) had pedicle screw loosening at the 24 month follow-up. Multivariable logistic regression analyses demonstrated that higher VBQ score (OR: 27.887 ± 0.514 ,95% CI: 10.189–76.326), male sex (female to male 0.323 ± 0.483, 0.126–0.833), and longer fusion length (2.578 ± 0.545, 1.166–5.701) were significant influencing factors for pedicle screw loosening. The VBQ score significantly predicted screw loosening with an accuracy of 78.9%.
Conclusions:
A higher VBQ score was an independent risk factor for pedicle screw loosening following instrumented TLIF. The MRI-based VBQ score showed good predictive ability for screw loosening and could be used as an alternative option for preoperative bone quality evaluation.
One-step preparation of a novel indium doped MoO3 photocatalyst with enhanced photocatalytic activity for RhB degradation
Authors: Ma Jiawei , Li Jingya , Feng Qi , Jiang Zao , Zhang Ru , Wu Ting , Liu Chenglun , Xu Longjun
Published: November 2023

In this work, a simple one-step hydrothermal approach was used to successfully manufacture a novel indium doped molybdenum trioxide (In-MoO3) photocatalyst for enhancing the photocatalytic degradation of Rhodamine B (RhB) under simulated light. The structural characterization of In-MoO3 confirms successful addition of indium ions to the MoO3 lattice. Importantly, the performance of the doped samples was significantly enhanced when the doping mass of indium accounted for 5% under simulated light, and the RhB degradation rate reached 96.2%. Even after four cycles, the doped sample proved to maintain excellent cycling stability. The proposed photocatalytic mechanism for the RhB degradation by In-MoO3 is presented. It is revealed that ·OH acts as the primary active species in this photocatalytic system, while ·O2− also plays a supporting role. Indium doping improves the light absorption and effectively reduces the interfacial charge transfer resistance and bandgap width, leading to significant progress in the photocatalytic performance of MoO3.
Improving multi-pinhole CZT myocardial perfusion imaging specificity without changing sensibility by using adapted prefilter parameters
Authors: Vauchot Fabien , Dubois Julien , Bourdon Aurélie
Published: November 2023

Background
Meta-analysis show the diagnostic performance of cardiac dedicated multi-pinhole CZT (cadmium-zinc-telluride) myocardial perfusion imaging (MPI) with a sensibility around 0.9 and a specificity around 0.7. The aim of the present study is to explore a simple method to generate less artefact on MPI using single photon emission computed tomography (SPECT) and to enhance specificity without changing sensibility.
Results
From October 2018 to March 2019, 200 patients who underwent SPECT with [99mTc]Tc-tetrofosmin were prospectively recruited: 100 patients with ischemia or necrosis diagnosis (first arm), and 100 patients with myocardial reversible SPECT artefact (second arm). Each SPECT was explored using two image process based on a Butterworth prefilter: the original image processing (treatment A) with a cut-off frequency equals to 37% of the Nyquist frequency and order equals to 7, and a second image processing (treatment B) with a cut-off frequency equals to 25% of the Nyquist frequency and order equals to 5. For each patient, sum stress or rest score with and without septum (SSRS and SSRSws) were calculated with the two treatments.
No significant statistical difference between SSRSa and SSRSb was identified for the first arm (P=0.54) and the relative difference ∆r was -0.5 ± 11.1 % (CI95 -2.6–1.8). We found a significant statistical difference between SSRSa and SSRSb for the second arm (p < 0.0001).
Conclusion
In conclusion, using a prefilter cut-off frequency equal to 25% of the Nyquist frequency before iterative reconstruction generates less artefact and improves myocardial SPECT specificity without affecting sensibility compared with the original treatment.
Fertile island effects across soil depths in drylands of the Tibetan Plateau
Authors: Ma Tao , Maestre Fernando T. , Eldridge David J. , Ke Wenbin , Hu Tenglong , Ye Jian-Sheng
Published: November 2023

Background and aims In arid regions, patches of vegetation serve a vital function in carbon and nutrient sequestration, fostering the emergence of 'fertile islands' within the soil beneath their canopies. However, the variation in the fertile island effects across soil depth remains an open question.
Methods To explore this, we sampled soils from two different layers (0-30 cm and 30-50 cm) within perennial vegetation patches and open areas across 54 drylands dispersed across the Tibetan Plateau. Our study focused on six key soil variables related to carbon, nitrogen, and phosphorus stocks, allowing us to assess the differences in fertile island effects at these varying depths.
Results Among six soil fertility parameters, organic carbon exhibited the most pronounced fertile island effect at both soil depths.. In the surface soil, the influence of vegetation in soil carbon content intensified with increasing precipitation seasonality and precipitation in the wettest quarter but declined with increasing temperature during the driest quarter. Conversely, in the deeper soil layer, the fertile island effect for nitrogen and phosphorus intensified with greater soil sand content and vegetation greenness.
Conclusions The fertile island effects responded differently to environmental factors at these two depths. These findings offer fresh and valuable insights into the interplay between environmental drivers and fertile island effects, a critical aspect of dryland ecosystems worldwide.
A novel artificial intelligence tool for identification of extracellular proteins doubles current estimate of the marine secretome
Authors: Baltar Federico , Zaragoza-Solas Asier
Published: November 2023

Microbes are the engines driving the elemental cycles. In order to interact with their environment and the community, microbes secrete proteins into the environment (known collectively as the secretome), where they remain active for prolonged periods of time. Despite the environmental relevance of microbes and the vast quantities of marine prokaryotic sequences available, our knowledge of the marine secretome remains limited due to the available in silico methods for the study of secreted proteins, which are not suited to their use in large datasets due to their low throughput. An alternative and potentially better approach to characterise the secretome is to combine modern machine learning tools with the evolutionary adaptation changes of the proteome to the marine environment. In this study, we found and described adaptations of marine extracellular proteins, which vary between phyla, resulting in differences in ATP costs, amino acid composition and nitrogen and sulphur content. With these adaptations in mind, we developed ‘Ayu’, a machine prediction tool that does not employ homology-based predictors (as current methods do) and achieves better performance than current state-of-the-art software at a fraction of the time. When applied to oceanic samples (Tara Oceans dataset), our method was able to recover more than double the proteins compared to the most widely used method to identify secreted proteins, indicating that more than half of secreted proteins are presently unconsidered in current secrtome analysis. The application of this powerful novel to open ocean samples allowed to better characterise the real composition of the marine secretome, allowing for a better recognition and understanding of the secretome in marine ecosystems.
Thermodynamic approach to modeling adsorption of gas mixtures by nanoporous adsorbents: Extension to non-ideal systems at high pressures
Authors: Kuznetsova Tatiana A. , Ustinov Eugene A.
Published: November 2023

In this study, we developed a phenomenological approach to describe equilibrium adsorption of non-ideal gas mixtures in nanoporous adsorbents over a wide pressure range, using individual adsorption isotherms as input. The main goal was achieving acceptable accuracy in predicting the adsorption of gas mixtures based on a relatively simple but general model, including a minimum of assumptions and adjusting parameters. The key point of the developed approach is the statement that the Gibbs free energy of mixing gases of any density is close to its ideal term, which is supported by numerical modeling in the grand canonical ensemble (E.A. Ustinov. PCCP 25, 27231). This conclusion, which is a more rigorous thermodynamic replacement for the empirical Raoult's law in the ideal adsorbed solution theory (IAST), was combined with the distribution of elements of the adsorption volume (EAV) of the adsorbent over potentials in the spirit of Polanyi's theory. The EAV potential distribution is determined from the adsorption isotherms of pure components. We applied this approach to the adsorption of individual and binary gas mixtures of CO2, CH4, and N2 on an activated carbon in a wide pressure range up to 13 MPa. It was established that binary mixtures in the adsorbed phase exhibit a weak positive non-ideality, which was accounted for by including the Margules equation with one adjusting parameter. The approach provides high accuracy in predicting the adsorption of gas mixtures based on individual adsorption isotherms and obeys the Gibbs-Duhem equation, which confirms its thermodynamic consistency.
Enhancing the Performance of Double-Slope Solar Still Using Nano-Enhanced Eutectic Phase Change Materials and Steel Wool Fiber as Wick Material
Authors: Gupta Sanjeev , Solanki S.C. , Agrawal Rahul
Published: November 2023

Energy storage in the form of sensible and latent heat is one of the prominent method to enhance the performance of any solar thermal system. Solar desalination is the viable method to convert the saline water into potable water but due to its lower yield, it can not be used as regular source of water. The current investigation deals with the enhancement in water yield of double slope solar still by embedding eutectic phase change material (PCM) (Myristic acid + Stearic acid), nano enhanced PCM and wick material (steel wool fibre). Ag2O3 nanoparticles at concentrations of 1.5 wt% were mixed in eutectic PCM to increase the thermal conductivity of nano enhanced PCM. The energy and exergy analyses of four various modified cases namely; CSS (Still without PCM), DSS-1 (Still with eutectic PCM), DSS-2 (Still with eutectic PCM and Steel wool fibre) and DSS-3 (Still with nano enhanced eutectic PCM) was carried out in central India (23.24° N and 77.41° E). The findings reveals that the cumulative yields for CSS, DSS-1, DSS-2 and DSS-3 are around 1.82, 2.44, 3.40, and 4.22 kg/m2. Additionally, DSS-3 cumulative fresh water production was around 132, 72.9 and 24.1% greater than that of CSS, DSS-1, and DSS-2 respectively. The average energy efficiency of DSS-3 was 49%, which is greater than CSS (22.21%), DSS-1 (30.42 %) and DSS-2 (41%). The findings also depict that the combined impact of PCM and nanoparticles displays an average exergy efficiency of 12.2%, which is greater than CSS, DSS-1 and DSS-2 by 3.18, 5.47, and 11%, respectively.
Enhancing the Cell Viability and Antibacterial Properties of Composite Layer by Active Particulate Additions
Authors: Al-Hasani Fatimah J. , Hamad Qahtan A. , Faheed Noor K.
Published: November 2023

Because of their exceptional biological, mechanical, and structural capabilities, polymer matrix composite materials are immensely appealing in the biomedical industry, particularly for surface activation of metallic implants and tissue engineering. The purpose of this research is to investigate the effect of adding 5% active metallic particles (Mg particles and Ag nanoparticles) to an alginate matrix on cell survival (fibroblast MG-36 cells), antibacterial activity, surface texture, roughness, and wettability. The incorporation of 5% Mg particles and Ag nanoparticles in polymeric matrix employed composite material with outstanding properties. The adding of Mg and Ag particles boosted wettability by decreasing the contact angle from 56.83° to 0°. The activity of Candida albicans and Porphyromanoas gingivalis was significantly reduced, particularly with Ag nanoparticles, which fight bacteria by blocking cell development and improving the antimicrobial properties of composite materials. The use of Ag nanoparticles to strengthen alginate resulted in higher fibroblast proliferation for MG-63 cell at the outer layer, which resulted in superior cell viability (24, 48, and 72). Meanwhile, due to Mg's high activity, the reverse effect was found when Mg particles were used, making the composite surface more active (enriched with Mg ions).
CacyBP/SIP knockdown inhibits cell cycle process of colon cancer by suppressing CDK8-mediated Wnt/β-catenin signaling pathway
Authors: Liang He-Jun , Ge Jun , Lin Hui-Lan , Liu Zi-Yu , Gu Feng , Zhu Jing-Yi , Li Zhi-Yu , Ma Lei , He Bo-Yuan , Zhang Xiao-Yan , Ge Yi , Chen Zhuo , Yuan Duo , Zhai Hui-Hong
Published: November 2023

Background
Previously, we found that calcyclin-binding or siah-1-interacting protein (CacyBP/SIP) promotes colon cancer proliferation. However, the potential mechanism has not been fully revealed.
Methods
CacyBP/SIP nuclear translocation was induced by gastrin in the SW480 cell line and verified by the Western blotting and qPCR. The ubiquitin and cell cycle microarrays were constructed to identify the downstream target proteins of CacyBP/SIP nuclear translocation. CacyBP/SIP and CDK8 expressions were detected by the immunohistochemistry (IHC) and validated by TCGA samples. The cell distributions were analyzed by the flow cytometry. Lentivirus-mediated shRNAs were used to perform the knockdown experiments. Ubiquitin degradation pathway was inhibited by the proteasome inhibitor MG132.
Results
CacyBP/SIP nuclear translocation was successfully induced under gastrin treatment for 48h. Gene chip screening confirmed that CDK8 was the key downstream target protein of CacyBP/SIP in the nucleus. CacyBP/SIP and CDK8 were highly expressed in primary colon cancer tissues compared to the adjacent and normal tissues. CacyBP/SIP knockdown decreased CDK8 and β-catenin expressions, causing a cell cycle arrest at the G0/1 phase. Meanwhile, knocking down CDK8 alone can inhibit the expression of β-catenin. In addition, MG132 inhibited the E3 ligases-mediated degradation pathway, up-regulating CDK8 expression. Furthermore, Skp2 knockdown suppressed the activity of the CacyBP/SIP-formed E3 ligase (CacyBP/SIP-Siah-1- Skp1-Cullin-1-Skp2), which facilitated CDK8 degradation by other E3 ligases.
Conclusion
CacyBP/SIP nuclear translocation contributes to the cell cycle progression of colon cancer via CDK8-mediated Wnt/β-catenin signaling pathway. Moreover, CacyBP/SIP can through E3 ligase-mediated regulation of CDK8 expression in colon cancer.
Modeling Rehabilitation Dataset to Implement Effective AI Assistive Systems
Authors: Mennella Ciro , Maniscalco Umberto , De Pietro Giuseppe , Esposito Massimo
Published: November 2023

The demand for automated systems monitoring and supporting patients in their home-based recovery programs is substantial. While emerging technologies have been proposed as potential solutions to enhance at-home patient care, limited systems are in place due to their challenges in offering real-time monitoring and corrective feedback. Most proposed methodologies provide an overall measure or score for the executed movement.
The proposed work involves the adaptation of an existing published dataset to cater to the needs of a system capable of remotely assisting patients, effectively acting as a virtual physical therapist able to provide corrective feedback. A dataset containing a set of three simple exercises for shoulder rehabilitation was processed. Each movement was meticulously annotated for temporal and cate- gorical motion domains to monitor exercise execution in terms of the range of motion completeness and to evaluate compensatory movement patterns.
This work carries substantial significance by offering a standardized and easily accessible model for human movement data, thus fostering the advancement of digital assistive systems designed to support home-based rehabilitation programs.
Characteristics and Clinical Outcomes of Patients Referred to a Cardio- Oncology Clinic: The First Lebanese Experience
Authors: Fakhreddine Omar , Alameh Ibrahim , Atoui Ali , Taher Ali , Bazarbachi Ali , Skouri Hadi
Published: November 2023

Introduction: Survival rates in cancer patients have improved dramatically in the past ten years, especially with the discovery of novel cancer therapy which was found to be associated with multiple cardiovascular complications. The development of cardio oncology clinics has evolved in order to address this issue.
Objectives: This study is aimed to report the characteristics and clinical outcomes of patients presenting to our cardio oncology clinic in order to improve the care for this patient population.
Material and Methods: Hematologic and solid malignancy patients referred to the cardio oncology clinic at the American University of Beirut Medical Center will be included in this study.
Results: Of the 119 patients, the median age was 59, and 57% were women. The most common reason for referral was pre-therapy assessment. After a follow up period of 12 months, 55% of the patients who had a drop in their LVEF achieved full recovery, 22.5% experienced partial improvement. 55% of the patients completed their chemotherapy regiment where 8% had discontinued the treatment at some point. 83% of patients were alive at the end of follow up, 17% died with septic shock being the most common cause.
Conclusion: Despite challenges, the COC demonstrated significant success in managing patients at risk or with known cardiovascular comorbidities who are being treated for cancer, emphasizing the importance of multidisciplinary care. These findings underscore the importance of specialized cardiac care within the realm of oncology and emphasize the need for early risk stratification, early preventive measures, and continued research to optimize the management of cardiovascular health in cancer patients.
Dural puncture epidural vs traditional epidural: A meta- analysis with trial sequential analysis of labor analgesia
Authors: Shi Haibin , Bian Yinglin , Zheng Caihong , Zhu Bin
Published: November 2023

Purpose
Dural puncture epidural (DPE) is a modified version of traditional epidural (EPL) that is performed by puncturing the dura mater with a spinal needle without intrathecal drug administration. We performed an updated meta-analysis of randomized controlled trials with trial sequential analysis (TSA) to compare the benefits and risks of DPE with those of EPL for labor analgesia in parturients.
Methods
Web of Science, Embase, PubMed, and the Cochrane Library were searched from inception to March 2023. The meta-analysis was conducted using fixed- or random-effects models to estimate risk ratios and mean differences (MDs) with 95% confidence intervals (CIs). The reliability of the meta-analysis results was examined using TSA. The primary outcome was the time to adequate analgesia, defined as a pain score of ≤ 3/10 (or 30/100). The secondary outcomes were maternal delivery and neonatal outcomes, quality of analgesia, and adverse effects.
Results
Twelve studies involving 1,259 patients were included. Compared with EPL, DPE required 4 fewer minutes to achieve a pain score of ≤ 3/10 (or 30/100) (weighted MD − 3.99, 95% CI − 4.54 to − 3.44, I2 (article heterogeneity) = 42%, p < 0.00001), and TSA confirmed these results. There were no significant differences in the secondary outcomes, except for the incidence of motor block. However, the TSA did not support all of the secondary outcomes.
Conclusion
Compared with EPL, DPE allowed faster relief of labor pain. There was no significant difference in the incidence of spontaneous and instrumental vaginal delivery, catheter adjustment and replacement, pruritus, post-dural puncture headache, or paresthesia between the two techniques.
Design of Rectifiable Bio-based Polybenzoxazine for Stimulated Self-Healing and Shape Memory applications with antimicrobial activity
Authors: Revathi A , Krishnadevi Krishnamoorthy , Anuradha V , Ramachandhran D
Published: November 2023

Worldwide, recycling of bio-waste into fixable self-healing materials is a big challenge, in this paper, a feasible approach used for to synthesis partially bio-based benzoxazine from cashew nut shells. Melamine, cardanol and paraformaldehyde have been used to develop bio-based benzoxazine monomer through the Mannich condensation reaction, which is then thermally co-polymerized with 2-Mercaptoethanol and Polyurethane. The structure of the monomer and composites have been confirmed by using traditional spectroscopy techniques. Our modified bio-based polybenzoxazine showed good self-healing and shape memory properties. The duration of the recovery process was significantly influenced by the thiol and polyurethane unit. The self-healing property of Poly(SH-co-CDL-m) Poly(U1/SH-co-CDL-m), Poly(U2/SH-co-CDL-m) was investigated with Scanning Electronic Microscopy analysis and Optical Microscopy analysis. Finally, the resultant bio-based CDL-m polybenzoxazine, which is achieved the goal of cleaner production by using biomass and reducing petrochemical recourses, production and energy emission.
Antifungal and antibacterial activities of Lippia callicarpifolia Kunth essential oils and influence of phenological stage on chemical composition
Authors: Villagómez-Guzmán Ana Karen , García-Bores Ana María , López-Perez Miriam Arlette , Estrella-Parra Edgar Antonio , Avila-Acevedo José Guillermo , Cansino Roció Gómez , Camilo Patricia Bustamante , Hernández-Delgado Claudia Tzasna
Published: November 2023

Background: Lippia callicarpifolia Kunth (Verbenaceae) is an aromatic perennial shrub popularly known as “flor de aire”, “mostranzo”, and “rosa de castilla” in the community of Tonatico, State of Mexico, Mexico. This study examined the influence of phenological stage on the chemical composition of essential oils (EOs) obtained from aerial parts collected at three different developmental periods and the impact on their antimicrobial activity against bacteria and yeasts of medical importance, including microorganisms isolated from clinical cases.
Methods: GC‒MS, retention indices, and standard compounds were employed to identify 38 constituents. The antimicrobial activity of the EOs was evaluated following the Clinical and Laboratory Standard Institute M100 guidelines (2018).
Results: During the pre-flowering stage (September), the essential oil of fresh leaves/stems (LSEP) was composed mainly of β-caryophyllene. In contrast, β-phellandrene, β-caryophyllene, and α-pinene were the major compounds in the EOs of leaves/stems and flowers collected during full bloom in November (LNOV and FNOV, respectively) and at the end the flowering stage in February (LFEB and FFEB, respectively). All EOs studied exhibited antibacterial and anticandidal activities. Determination of minimal inhibitory concentrations (MICs) and bactericidal or fungicidal concentrations (MBCs or MFCs) revealed that the most significant antimicrobial activity was observed for the essential oils LNOV and FNOV. LNOV showed the highest level of antifungal activity, significantly inhibiting the growth of Candida glabrata (with an MIC value of 0.5 mg/mL). In addition, the essential oil of flowers FNOV exhibited a broader antibacterial spectrum, effectively inhibiting the development of all gram-negative and gram-positive bacteria studied, including multidrug-resistant strains isolated from clinical cases. The LSEP, LNOV, and FNOV EOs inhibited C. glabrata biofilm formation.
Conclusions: The EOs of L. callicarpifolia Kunth may be a viable alternative source of naturally occurring antimicrobial agents for effectively combating infectious diseases that offer an affordable approach to treatment. This study examines for the first time the chemical composition of L. callicarpifolia EOs during different growth stages, including vegetative and flowering stages, along with their antimicrobial activity.
Fat-1 Gene Inhibit Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice
Authors: li yixian , zhao yan , liu xinxin
Published: November 2023

Background and Aim:
n-3 PUFAs have been shown to have multiple biological effects on cancers. The fat-1 gene encodes an n-3 desaturase that introduces a double bond at the n-3 position of the hydrocarbon chain in n-6 fatty acids to form an n-3 fatty acid. Here we investigated the anti-tumorigenesis effect of Fat-1 gene.
Methods: Mounting evidence indicates that activation of AKT and Ras pathways is a key oncogenic event in human hepatocarcinogenesis. Our previous results demonstrate that co-expression of AKT and N-Ras in the mouse liver promotes rapid hepatocarcinogenesis in vivo. Here we utilized hydrodynamic tail vein injection of Fat-1 gene to AKT/Ras hepatocarcinogenesis' model to testify its anti-tumorigenesis effect.
Results: Hydrodynamic injection of Fat-1 gene could inhibit lipogenesis and affects liver tumor development in co-expressing AKT and Ras oncogenes' mice. Molecular analysis showed that Fat-1 gene strongly inhibited the Ras/MAPK and Akt/ mTORC cell signal pathway, and significantly inhibited de novo lipogenesis by inhibition of fatty acid biosynthesis gene (FASN, ACLY) and transcription factors (LXR-β, SREBP1), which were highly elevated in AKT/Ras mice. The AKT/Ras cells lines in vitro also showed the similar results. Noticeably, although the hydrodynamic injection of fat-1 gene showed significant inhibition effect of hepatocarcinogenesis, it didn't change fatty acid profile in various tissues of mice, which is different from previous studies by using Fat-1 transgenic mice.
Conclusions Local expression of Fat-1 gene can achieve sufficient suppression of AKT/Ras-induced hepatocarcinogenesis. Thus, with multiple biological effects on various signal pathways, Fat-1 gene can prevent of hepatocarcinogenesis.
Copaiba oil’s bactericidal activity and its effects on health and zootechnical performance for Nile tilapia after oral supplementation
Authors: Mello Nicoli Paganoti , Espinoza Fernando Carlos Ramos , Claudiano Gustavo da Silva , Yunis-Aguinaga Jefferson , Carvalho Janaina Graça de Oliveira , Silva Josiane Elizabeth Almeida , de Oliveira Elaine Cristina Pacheco , de Moraes Julieta Rodini Engrácia
Published: November 2023

This study aimed to verify the bactericidal activity of Copaiba oil, Copaifera duckei, against the main tilapia pathogens and the effect on dietary levels of commercial Copaiba oil for 30 days on zootechnical performance, hematological, biochemical, immunological and histological parameters before and after an experimental infection with Streptococcus agalactiae in Nile tilapia. Fish were randomly distributed into 15 fiber tanks in five treatments (0%, 0.25%, 0.50%, 0.75% and 1.0%) and fed with commercial diet supplemented wit Copaiba oil for 30 days. After this period, the fish were randomly redistributed for the experimental challenge with S. agalactiae into six treatments (T0, T1, T2, T3, T4 and T5) and the fish were anesthetized, and blood samples were collected to assess hematological, biochemical, immunological and histological parameters. Copaiba oil showed bactericidal activity against Streptococcus spp. and Flavobacterium spp. in vitro. In addition, concentrations of 0.75% and 1.0% has an anti-inflammatory effect and improve hematological and immunological parameters, increasing the leukocyte numbers, albumin and serum lytic activity. Furthermore, there is an increase in the intestinal villus length and tissue damage in groups at concentrations 0.75% and 1.0% of Copaiba oil. In conclusion, oral supplementation enhanced non-specific immune parameters and digestibility in Nile Tilapia.
Advances in Online Delivery: Introducing and Optimizing a Novel Multi-Objective Function
Authors: Tunga Harinandan , Chowdhury Rupaj , Kar Samarjit , Giri Debasis , Gandomi Amir H
Published: November 2023

An efficient online delivery system in the dynamic landscape is a challenging task. The challenges occur due to the difficulty in generating a proper objective function that can represent theperformance of the delivery system. In this paper, we propose a novel multi-objective function that represents the utility score and time required in the delivery process. The utility score takes into consideration the number of previous orders given by a particular customer. The Time window methodology is used to achieve the two objectives. The multi-objective optimization functions are solved and compared using three multi-objective algorithms. They are Non-dominated sorting genetic algorithm-II (NSGA-II), strength Pareto evolutionary algorithm 2 (SPEA2), and indicator-based evolutionary algorithm (IBEA). The performances are compared extensively and it is found that SPEA2 gives better convergence performance. The proposed objective function minimizes the limitation of currently available methods for online delivery systems.
The efficacy and safety of androgen receptor signaling inhibitors in patients with non-metastatic castration resistant prostate cancer
Authors: Takahara Kiyoshi , Naiki Taku , Nakane Keita , Watanabe Hiromitsu , Miyake Hideaki , Koie Takuya , Yasui Takahiro , Shiroki Ryoichi
Published: November 2023

BACKGROUND
The treatment paradigm for non-metastatic castration resistant prostate cancer (nmCRPC) has changed in recent years. An observational multicenter study was conducted to evaluate the effectiveness of androgen receptor signaling inhibitors (ARSI) as a first-line treatment for patients with nmCRPC.
METHODS
The primary endpoint of this study was to evaluate the efficacy and safety of ARSI in native Japanese patients who received ARSI as a first-line treatment for nmCRPC. The secondary endpoint was to develop a novel system to stratify the prognoses of these patients.
RESULTS
In total, 160 patients were enrolled in this study. Within a median follow-up period of 23 months, the median overall survival (OS) was not reached, whereas the median progression-free survival was 26 months. Multivariate Cox regression analyses showed that the time to CRPC, PSA level at the initiation of nmCRPC treatment, and Geriatric Nutritional Risk Index (GNRI) were independent predictors of OS. The patients were subsequently divided into three groups as follows: Group 1, 57 patients with negative or one positive independent OS predictor; Group 2, 38 patients with two positive independent OS predictors; and Group 3, 10 patients with three independent OS predictors. The OS differed significantly among the three groups (p < 0.0001).
CONCLUSION
ARSI may provide favorable outcomes for Japanese patients with nmCRPC as a first-line treatment. Time to CRPC, PSA level at the initiation of nmCRPC treatment, and GNRI are potential predictors of OS in Japanese patients with nmCRPC who received ARSI as a first-line treatment.
Will You Become the Next Troll? A Computational Mechanics Approach to the Contagion of Trolling Behavior
Authors: Sun Qiusi , Hilbert Martin
Published: November 2023

Trolling is a deviant behavior that provokes emotional responses, diffuses misinformation, or otherwise disrupts on-topic discussions. This study investigates trolling behavior as a complex dynamic process. The data comprised over 13 million Reddit comments, which were classified as troll or non-troll messages using the BURT model, fine-tuned with human coding set. By employing a unique, minimally complex, maximally predictive model from statistical mechanics and information theory, i.e., epsilon-machines and transducers, we find that engaging in trolling behaviors is both self- and other-motivated. Social inputs provide more information for predicting the future behaviors of the dynamic. Social inputs are also shown to encourage and reinforce trolling behaviors among Internet users. The article serves as a showcase for the use of information-theoretic measures from dynamical systems theory to conceptualize social media processes as computational algorithms executed by collectives of human users.
Assessment of Payments For Watershed Services Policy from a Perspective of Ecosystem Services: A Case Study of the Liaohe River Basin, China
Authors: Guo Manman , Lu Xu , Ma Qing
Published: November 2023

Payments for watershed services (PWS), as one of the typical environmental governance policies, its efficiency assessment has become a research focus. Taking the Liaohe River in China as an example, this study try to find a more suitable assessment method for PWS. we divided its Payments for Watershed Services (PWS) policy into two types, including EC-like model (October 2008 to April 2017) and PES-like model (May 2017 to December 2021), and then by adopting the corrected uint-value transfer method based on the land use change data, we presented a comparison of the service efficiencies of the two phases based on the assessment method of ecosystem service value (ESV). According to the results, the total ESV growth in phase Ⅰ was 15.23 billion yuan, with an average value of 1.69 billion yuan per year; the numbers in phase Ⅱ was 14.86 and 3.72. The main growth spaces were concentrated along the Liaohe River mainstream and the upstream of tributaries, the main growth functions were water regulation (45.12%) and climate regulation (24.32%). The ESV growth were mainly due to the conversion of farmland into forest, grassland, wetland and water. In addition, in the PES-like model, the growth efficiency for the cities that adopted a direct payment system among counties was higher than for cities that did not take this step. In theory, the more people participate, the higher the service efficiency is, this is the main reason why the efficiency of PES is higher than that of EC in this study. Taking the ESV as the main indicator for PWS assessment, can not only conduct policy assessment and comparison, but also effectively identify land types and governance measures that generate positive externality of ecosystem.
Host immune responses associated with SARS-CoV-2 Omicron infection result in protection or pathology during reinfection depending on mouse genetic background.
Authors: Singh Gagandeep , Warang Prajakta , Diego Juan García-Bernalt , Chang Lauren , Bykov Yonina , Singh Sarabjot , Pache Lars , Cuadrado-Castano Sara , Webb Brett , Garcia-Sastre Adolfo , Schotsaert Michael
Published: November 2023

Rapid emergence of antigenic distinct SARS-CoV-2 variants implies a greater risk of reinfection as viruses can escape neutralizing antibodies induced by vaccination or previous viral exposure. Disease severity during COVID-19 depends on many variables such as age-related comorbidities, host immune status and genetic variation. The host immune response during infection with SARS-CoV-2 may contribute to disease severity, which can range from asymptomatic to severe with fatal outcome. Furthermore, the extent of host immune response activation may rely on underlying genetic predisposition for disease or protection. To address these questions, we performed immune profiling studies in mice with different genetic backgrounds - transgenic K18-hACE2 and wild-type 129S1 mice – subjected to reinfection with the severe disease-causing SARS-CoV-2 B.1.351 variant, 30 days after experimental milder BA.1 infection. BA.1 preinfection conferred protection against B.1.351-induced morbidity in K18-hACE2 mice but aggravated disease in 129S1 mice. We found that he cytokine/chemokine profile in B.1.351 re-infected 129S1mice is similar to that during severe SARS-CoV-2 infection in humans and is characterized by a much higher level of IL-10, IL-1β, IL-18 and IFN-γ, whereas in B.1.351 re-infected K18-hACE2 mice, the cytokine profile echoes the signature of naïve mice undergoing viral infection for the first time. Interestingly, the enhanced pathology observed in 129S1 mice upon reinfection cannot be attributed to a less efficient induction of adaptive immune responses to the initial BA.1 infection, as both K18-hACE2 and 129S1 mice exhibited similar B and T cell responses at 30 DPI against BA.1, with similar anti-BA.1 or B.1.351 spike-specific ELISA binding titers, levels of germinal center B-cells, and SARS-CoV-2-Spike specific tissue-resident T-cells. Long-term effects of BA.1 infection are associated with differential transcriptional changes in bronchoalveolar lavage-derived CD11c + immune cells from K18-hACE2 and 129S1, with K18-hACE2 CD11c + cells showing a strong antiviral defense gene expression profile whereas 129S1 CD11c + cells showed a more pro-inflammatory response. In conclusion, initial infection with BA.1 induces cross-reactive adaptive immune responses in both K18-hACE2 and 129S1 mice, however the different disease outcome of reinfection seems to be driven by differential responses of CD11c + cells in the alveolar space.