bluuebunny/crossref_metadata_2025 huggingface dataset:
Spinful hinge states in the higher-order topological insulators WTe2
Authors: Lee Jekwan , Kwon Jaehyeon , Lee Eunho , Park Jiwon , Cha Soonyoung , Watanabe Kenji , Taniguchi Takashi , Jo Moon-Ho , Choi Hyunyong
Published: March 2023

Higher-order topological insulators are recently discovered quantum materials exhibiting distinct topological phases with the generalized bulk-boundary correspondence. Td-WTe2 is a promising candidate to reveal topological hinge excitation in an atomically thin regime. However, with initial theories and experiments focusing on localized one-dimensional conductance only, no experimental reports exist on how the spin orientations are distributed over the helical hinges—this is critical, yet one missing puzzle. Here, we employ the magneto-optic Kerr effect to visualize the spinful characteristics of the hinge states in a few-layer Td-WTe2. By examining the spin polarization of electrons injected from WTe2 to graphene under external electric and magnetic fields, we conclude that WTe2 hosts a spinful and helical topological hinge state protected by the time-reversal symmetry. Our experiment provides a fertile diagnosis to investigate the topologically protected gapless hinge states, and may call for new theoretical studies to extend the previous spinless model.
Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma
Authors: Chung Jeff Yat-Fai , Tang Philip Chiu-Tsun , Chan Max Kam-Kwan , Xue Vivian Weiwen , Huang Xiao-Ru , Ng Calvin Sze-Hang , Zhang Dongmei , Leung Kam-Tong , Wong Chun-Kwok , Lee Tin-Lap , Lam Eric W-F , Nikolic-Paterson David J. , To Ka-Fai , Lan Hui-Yao , Tang Patrick Ming-Kuen
Published: March 2023

Neutrophils are dynamic with their phenotype and function shaped by the microenvironment, such as the N1 antitumor and N2 pro-tumor states within the tumor microenvironment (TME), but its regulation remains undefined. Here we examine TGF-β1/Smad3 signaling in tumor-associated neutrophils (TANs) in non-small cell lung carcinoma (NSCLC) patients. Smad3 activation in N2 TANs is negatively correlate with the N1 population and patient survival. In experimental lung carcinoma, TANs switch from a predominant N2 state in wild-type mice to an N1 state in Smad3-KO mice which associate with enhanced neutrophil infiltration and tumor regression. Neutrophil depletion abrogates the N1 anticancer phenotype in Smad3-KO mice, while adoptive transfer of Smad3-KO neutrophils reproduces this protective effect in wild-type mice. Single-cell analysis uncovers a TAN subset showing a mature N1 phenotype in Smad3-KO TME, whereas wild-type TANs mainly retain an immature N2 state due to Smad3. Mechanistically, TME-induced Smad3 target genes related to cell fate determination to preserve the N2 state of TAN. Importantly, genetic deletion and pharmaceutical inhibition of Smad3 enhance the anticancer capacity of neutrophils against NSCLC via promoting their N1 maturation. Thus, our work suggests that Smad3 signaling in neutrophils may represent a therapeutic target for cancer immunotherapy.
A mass spectrum-oriented computational method for ion mobility-resolved untargeted metabolomics
Authors: Luo Mingdu , Yin Yandong , Zhou Zhiwei , Zhang Haosong , Chen Xi , Wang Hongmiao , Zhu Zheng-Jiang
Published: March 2023

Ion mobility (IM) adds a new dimension to liquid chromatography-mass spectrometry-based untargeted metabolomics which significantly enhances coverage, sensitivity, and resolving power for analyzing the metabolome, particularly metabolite isomers. However, the high dimensionality of IM-resolved metabolomics data presents a great challenge to data processing, restricting its widespread applications. Here, we develop a mass spectrum-oriented bottom-up assembly algorithm for IM-resolved metabolomics that utilizes mass spectra to assemble four-dimensional peaks in a reverse order of multidimensional separation. We further develop the end-to-end computational framework Met4DX for peak detection, quantification and identification of metabolites in IM-resolved metabolomics. Benchmarking and validation of Met4DX demonstrates superior performance compared to existing tools with regard to coverage, sensitivity, peak fidelity and quantification precision. Importantly, Met4DX successfully detects and differentiates co-eluted metabolite isomers with small differences in the chromatographic and IM dimensions. Together, Met4DX advances metabolite discovery in biological organisms by deciphering the complex 4D metabolomics data.
Substrate effects on spin relaxation in two-dimensional Dirac materials with strong spin-orbit coupling
Authors: Xu Junqing , Ping Yuan
Published: March 2023

Understanding substrate effects on spin dynamics and relaxation is of key importance for spin-based information technologies. However, the key factors that determine such effects, in particular for materials with strong spin-orbit coupling (SOC), have not been well understood. Here we performed first-principles real-time density-matrix dynamics simulations with SOC and the electron-phonon and electron-impurity scattering for spin lifetimes (τs) of supported/free-standing germanene, a prototypical strong SOC 2D Dirac material. We show that the effects of different substrates on τs can surprisingly differ by two orders of magnitude. We find that substrate effects on τs are closely related to substrate-induced modifications of the SOC-field anisotropy, which changes the spin-flip scattering matrix elements. We propose a new electronic quantity, named spin-flip angle θ↑↓, to characterize spin relaxation through intervalley spin-flip scattering. We find that $${\tau }_{s}^{-1}$$

τ

s

−
1

is approximately proportional to the averaged value of $${\sin }^{2}\left({\theta }^{\uparrow \downarrow }/2\right)$$

sin

2

θ

↑
↓

/
2

, which serves as a guiding parameter of controlling spin relaxation.
No evidence for a common blood microbiome based on a population study of 9,770 healthy humans
Authors: Tan Cedric C. S. , Ko Karrie K. K. , Chen Hui , Liu Jianjun , Loh Marie ,   SG10K_Health Consortium, Chia Minghao , Nagarajan Niranjan
Published: March 2023

Human blood is conventionally considered sterile but recent studies suggest the presence of a blood microbiome in healthy individuals. Here we characterized the DNA signatures of microbes in the blood of 9,770 healthy individuals using sequencing data from multiple cohorts. After filtering for contaminants, we identified 117 microbial species in blood, some of which had DNA signatures of microbial replication. They were primarily commensals associated with the gut (n = 40), mouth (n = 32) and genitourinary tract (n = 18), and were distinct from pathogens detected in hospital blood cultures. No species were detected in 84% of individuals, while the remainder only had a median of one species. Less than 5% of individuals shared the same species, no co-occurrence patterns between different species were observed and no associations between host phenotypes and microbes were found. Overall, these results do not support the hypothesis of a consistent core microbiome endogenous to human blood. Rather, our findings support the transient and sporadic translocation of commensal microbes from other body sites into the bloodstream.
Model for predicting early and late-onset postoperative pulmonary complications in perioperative patients receiving neuromuscular blockade: a secondary analysis
Authors: Aragón-Benedí Cristian , Oliver-Forniés Pablo , Pascual-Bellosta Ana , Ortega-Lucea Sonia , Ramírez-Rodriguez José Manuel , Martínez-Ubieto Javier ,   Research Group in Anaesthesia, Resuscitation, and Perioperative Medicine of Institute for Health Research Aragón (ISS Aragón), Aragón-Benedí Cristian , Pascual-Bellosta Ana , Ortega-Lucea Sonia , Martinez-Ubieto Javier , Muñoz-Rodríguez Luis Alfonso , Pérez-Navarro Guillermo , Quesada-Gimeno Natividad , Hormigón-Ausejo Mariana , de Miguel-Garijo Raquel , Jiménez-Bernadó Teresa , Pérez-Otal Berta , Heredia-Coca Carmen
Published: March 2023

Pulmonary complications continue to be the most common adverse event after surgery. The main objective was to carry out two independent predictive models, both for early pulmonary complications in the Post-Anesthesia Care Unit and late-onset pulmonary complications after 30 postoperative days. The secondary objective was to determine whether presenting early complications subsequently causes patients to have other late-onset events. This is a secondary analysis of a cohort study. 714 patients were divided into four groups depending on the neuromuscular blocking agent, and spontaneous or pharmacological reversal. Incidence of late-onset complications if we have not previously had any early complications was 4.96%. If the patient has previously had early complications the incidence of late-onset complications was 22.02%. If airway obstruction occurs, the risk of atelectasis increased from 6.88 to 22.58% (p = 0.002). If hypoxemia occurs, the incidence increased from 5.82 to 21.79% (p < 0.001). Based on our predictive models, we conclude that diabetes mellitus and preoperative anemia are two risk factors for early and late-onset postoperative pulmonary complications, respectively. Hypoxemia and airway obstruction in Post-Anesthesia Care Unit increased four times the risk of the development of pneumonia and atelectasis at 30 postoperative days.
Climate for evidence-based mental health care implementation in Germany: psychometric investigation of the Implementation Climate Scale (ICS)
Authors: Szota Katharina , Christiansen Hanna , Aarons Gregory A. , Ehrhart Mark G. , Fischer Anne , Rosner Rita , Steil Regina , Barke Antonia
Published: March 2023

Organizational implementation climate is an important construct in implementation research to describe to what extent implementation is expected, supported, and rewarded. Efforts in bridging the research-practice gap by implementing evidence-based practice (EBP) can benefit from consideration of implementation climate. The Implementation Climate Scale (ICS) is a psychometrically strong measure assessing employees’ perceptions of the implementation climate. The present cross-sectional study aimed at providing a German translation and investigating its psychometric properties. The translation followed standard procedures for adapting psychometric instruments. German psychotherapists (N = 425) recruited online completed the ICS, the Evidence Based Practice Attitudes Scale (EBPAS-36D) and the Intention Scale for Providers (ISP). We conducted standard item and reliability analyses. Factorial validity was assessed by comparing an independent cluster model of Confirmatory Factorial Analysis (ICM-CFA), a Bifactor CFA, a Second-order CFA and an (Bifactor) Exploratory Structural Equation Model (ESEM). Measurement invariance was tested using multiple-group CFA and ESEM, convergent validity with correlation analysis between the ICS and the ISP subjective norms subscale (ISP-D-SN). The mean item difficulty was pi = .47, mean inter-item correlation r = .34, and mean item-total correlation ritc = .55. The total scale (ω = 0.91) and the subscales (ω = .79–.92) showed acceptable to high internal consistencies. The model fit indices were comparable and acceptable (Second-order CFA: RMSEA [90% CI] = .077 [.069; .085], SRMR = .078, CFI = .93). Multiple-group CFA and ESEM indicated scalar measurement invariance across gender and presence of a psychotherapy license. Psychotherapists in training reported higher educational support for EBP than licensed psychotherapists (T = 2.09, p = .037, d = 0.25). The expected high correlation between the ICS and the ISP-D-SN was found (r = .59, p < .001). Results for the German ICS confirm good psychometric properties including validity.
Assessment of pathogenic variation in gynecologic cancer genes in a national cohort
Authors: Kotnik Urška , Maver Aleš , Peterlin Borut , Lovrecic Luca
Published: March 2023

Population-based estimates of pathogenic variation burden in gynecologic cancer predisposition genes are a prerequisite for the development of effective precision public health strategies. This study aims to reveal the burden of pathogenic variants in a comprehensive set of clinically relevant breast, ovarian, and endometrial cancer genes in a large population-based study. We performed a rigorous manual classification procedure to identify pathogenic variants in a panel of 17 gynecologic cancer predisposition genes in a cohort of 7091 individuals, representing 0.35% of the general population. The population burden of pathogenic variants in hereditary gynecologic cancer-related genes in our study was 2.14%. Pathogenic variants in genes ATM, BRCA1, and CDH1 are significantly enriched and the burden of pathogenic variants in CHEK2 is decreased in our population compared to the control population. We have identified a high burden of pathogenic variants in several gynecologic cancer-related genes in the Slovenian population, most importantly in the BRCA1 gene.
Excellent thermoelectric properties of the Tl2S3 monolayer for medium-temperature applications
Authors: Zhou Lang , Wang Qi , Xu Mei , Hu Chengwei , Deng Xue , Li Yumin , Lv Bing , Wang Wenzhong
Published: March 2023

In this paper, a novel thermoelectric material with ZT as high as 2.8 at medium temperature has been discovered, and the study shows that strong acoustic-optic coupling is a crucial factor for ultra-low lattice thermal conductivity.
Review of quantitative and qualitative methods for monitoring photopolymerization reactions
Authors: Szymaszek Patryk , Tomal Wiktoria , Świergosz Tomasz , Kamińska-Borek Iwona , Popielarz Roman , Ortyl Joanna
Published: March 2023

Authomatic in-situ monitoring and characterization of photopolymerization.
Clickable polymer scaffolds enable Ce recovery with peptide ligands
Authors: Hostert Jacob D. , Sepesy Maura R. , Duval Christine E. , Renner Julie N.
Published: March 2023

Rare earth elements (REEs) are a vital part of many technologies with particular importance to the renewable energy sector and there is a pressing need for environmentally friendly and sustainable processes to recover and recycle them from waste streams.
ZIF-8 thin films by a vapor-phase process: limits to growth
Authors: Perrot Virginie , Roussey Arthur , Benayad Anass , Veillerot Marc , Mariolle Denis , Solé-Daura Albert , Mellot-Draznieks Caroline , Ricoul Florence , Canivet Jérôme , Quadrelli Elsje Alessandra , Jousseaume Vincent
Published: March 2023

An improved gas phase process using cyclic ligand/water exposures allows to reach high thickness of ZIF-8. Combination of surface analyses and molecular dynamics calculations highlights the importance of defects in the growth mechanism.
Functionalization of casein and its use for preparing self-crosslinking protein-based materials
Authors: Cencha Luisa G. , Allasia Mariana , Vaillard Victoria A. , Nieres Pablo D. , Córdoba Carlos A. , Gugliotta Luis M. , Vaillard Santiago E. , Minari Roque J.
Published: March 2023

The incorporation of ketone groups into casein confers the self-crosslinking capability through the keto-hydrazide reaction on modified protein. Film-forming materials are prepared, in which the crosslinking reaction proceeds after water evaporation.
High-affinity single and double helical pseudofoldaxanes with cationic guests
Authors: Zhong Yulong , Sobiech Thomas A. , Kauffmann Brice , Song Bo , Li Xiaopeng , Ferrand Yann , Huc Ivan , Gong Bing
Published: March 2023

Helical aromatic oligoamide foldamers provide negative cavities that strongly bind dicationic guests, giving complexes as stable pseudofoldaxanes with few precedents.
Magnetically controlled bio-inspired elastomeric actuators with high mechanical energy storage
Authors: Lalegani Dezaki Mohammadreza , Bodaghi Mahdi
Published: March 2023

A bioinspired design of pre-stressed soft magnetic actuators with high-speed shape recovery and strong grasping force is presented. The pre-stretched magnetic actuator can hold load weights even with zero-magnetic field strength.
5G mmWave patch antenna array with proximity sensing function for detecting user's hand grip on mobile terminals
Authors: Yoo Jeong‐Ung , Son Hae‐Won
Published: March 2023

We propose a new concept millimetre‐wave patch antenna that integrates the functions of an antenna and a capacitive proximity sensor to detect the hand grip state for 5G mobile terminals and compensate for the hand effect. The proposed antenna has the structure of a proximity‐coupled fed patch and functions as a proximity sensor by using the capacitance change of the patch that occurs when the user's hand approaches the patch. By observing the capacitance change at the centre of the patch operating in the TM01 mode, it is possible to simultaneously perform the functions of antenna and sensor without mutual interference. The proposed antenna is implemented as a 1 × 4 array. The experimental results show that it has a stable gain of 8.3 to 10.1 dBi at 26.5 to 29.5 GHz and can operate as a proximity sensor with a capacitance change of 200 fF according to the proximity of the hand.
Design of vehicle positioning system based on artificial intelligence cloud computing technology
Authors: Liang Jifeng
Published: March 2023

With the continuous progress of society, people's living consumption needs are also constantly changing. The traditional vehicle positioning technology can no longer meet the new positioning needs of travelers, so a more accurate positioning system is urgently needed. This paper aims to study a more accurate positioning system and proposes a vehicle positioning system based on radio frequency identification (RFID). After comparing several common positioning methods, the use of LANDMARC positioning algorithm makes the vehicle positioning more accurate. This paper has effectively integrated advanced computer and artificial intelligence technology and applies it to control and management and finally established a comprehensive traffic positioning system that can effectively alleviate traffic congestion, reduce traffic accidents and quickly deal with traffic emergencies. The experimental results have shown that when the vehicle runs at a speed of 40 km/h and the communication rate is 860 kpbs, the average positioning accuracy of the improved algorithm is doubled compared with the traditional algorithm, and the error is reduced by nearly one. Therefore, compared with the traditional positioning system and artificial intelligence, the RFID vehicle positioning system under cloud computing has more accurate positioning information and more timely and convenient services.
Spatial distribution of isotopes and compositional mixing in the inner protoplanetary disk
Authors: Shuai Kang , Hui Hejiu , Zhou Li-Yong , Li Weiqiang
Published: March 2023

The mass-independent isotopic signatures of planetary bodies have been widely used to trace the mixing process that occurred during planet formation. The observed isotopic variations among meteorite parent bodies have been further linked to the modeled mass-weighted mean initial semimajor axes in N-body simulations, assuming a spatial isotopic gradient in the inner protoplanetary disk. However, nucleosynthetic isotopic anomalies of nonvolatile elements and mass-independent oxygen isotopic variation (∆17O) show different relationships with distance from the Sun. Therefore, it is crucial to know whether isotopes were distributed systematically with heliocentric distance in the inner protoplanetary disk. In this study, we performed N-body simulations on compositional mixing during the collisional accretion and migration of planetary bodies to investigate the spatial distributions of Cr and O isotopes in the inner protoplanetary disk. The modeled mass-weighted mean initial semimajor axes of the parent bodies of noncarbonaceous (NC) meteorites and terrestrial planets were used to calculate the isotopic compositions of these bodies. Our simulations successfully reproduced the observed nucleosynthetic Cr isotopic anomaly among Earth, Mars, and the NC meteorite parent bodies, consistent with a spatial gradient of isotopic anomalies in the inner disk. Asteroids originating from different regions in the inner disk were transported to the main belt in our simulations, resulting in the Cr isotopic anomaly variation of the NC meteorite parent bodies. However, the ∆17O distribution among the terrestrial planets and the NC meteorite parent bodies could not be reproduced assuming a ∆17O gradient in the inner protoplanetary disk. The spatial gradient of the nucleosynthetic isotopic anomaly may be a result of changing isotopic compositions in the infalling materials, or reflect the progressive thermal processing of presolar materials. In contrast, the absence of a ∆17O gradient reflects that the oxygen isotopic mass-independent fractionation might have altered the spatial distribution of the nucleosynthetic ∆17O variation in the inner protoplanetary disk before protoplanets formed.
Combined X-ray and optical analysis to probe the origin of the plateau emission in γ-ray burst afterglows
Authors: Ronchini S. , Stratta G. , Rossi A. , Kann D. A. , Oganeysan G. , Dall’Osso S. , Branchesi M. , De Cesare G.
Published: March 2023

A large fraction of γ-ray bursts (GRBs) show a plateau phase during the X-ray afterglow emission, which has a physical origin that is still debated. In this work, we select a sample of 30 GRBs with simultaneous X-ray and optical data during and after the plateau phase. Through a time-resolved spectral analysis of the X-ray plateaus, we test the consistency of the unabsorbed optical fluxes with those obtained via X-ray-to-optical spectral extrapolation by assuming a synchrotron spectrum. By combining X-ray with optical data, we find that 63% (19/30) of GRBs are compatible with a single synchrotron spectrum, thus suggesting that both the optical and X-ray radiations are produced from a single emitting region. For these GRBs, we derive the temporal evolution of the break frequency, and we compare it with the expectations predicted by several models. For 11 of the 30 GRBs, the optical emission is above the predicted range of values extrapolated from the X-rays in at least one temporal bin of the light curve. These 11 GRBs may not be explained with a single-zone emission, indicating the necessity of invoking two co-operating processes in order to explain the broad-band spectral behaviour. We discuss our findings in the framework of different scenarios that are invoked to explain the plateau feature, including the energy injection from a spinning-down magnetar and the high latitude emission from a structured jet.
Finite element modeling of integral viscoelastic properties of textile composites
Authors: Dimitrienko Yu. , Yurin Yu. , Bogdanov I. , Yahnovskiy A. , Sborschikov S. , Dimitrienko A.
Published: March 2023

The problem of modeling the effective integral viscoelastic properties of unidirectional composite materials is considered. To calculate the integral properties of viscoelasticity, the Fourier transform and the inverse Fourier transform are used, as well as the method of asymptotic averaging for composites with steady polyharmonic vibrations, and a finite element algorithm for solving local problems of the viscoelasticity theory on the periodicity cell of the composite. To obtain the material constants, a method of approximation of the Fourier images of the relaxation and creep kernels is proposed, which makes it possible to avoid the numerical error of the inverse Fourier transform.
Modeling of effective elastic-plastic properties of layered composites with a periodic structure in the framework of the anisotropic flow theory
Authors: Dimitrienko Yu. , Gubareva E. , Cherkasova M.
Published: March 2023

The article is devoted to the development of a method for constructing theoretical strain diagrams. The method is based on the use of a model of effective constitutive relations for approximating the deformation diagrams of layered composites obtained using the asymptotic averaging method. To find the elastic constants of the model of a transversally isotropic composite, the method of minimizing the deviation of the approximation deformation diagrams from the diagrams obtained by the asymptotic homogenization (AH) method is used for a series of standard problems of deformation at small deformations. Minimization problems were solved using the Hooke-Jeeves method. The results of numerical simulation by the proposed method for layered composites are presented, which showed good approximation accuracy, which is achieved due to the proposed method for separating the coupled problems of micro- and macroscopic deformation.
On the question of the smallest rolling resistance coefficient value of elastic wheel on a rigid horizontal surface
Authors: Mamaev Alexey , Balabina Tatiana , Karelina Maria
Published: March 2023

As is known, rolling resistance of an elastic wheel on a rigid support surface is determined by internal friction losses (hysteresis) in the wheel material and friction losses in the contact of wheel with support surface (friction losses in the hub bearings and aerodynamic losses are neglected due to their smallness compared to with the above). To assess rolling resistance, the rolling resistance coefficient is used, which is defined as ratio of rolling resistance force applied to the wheel axle to the normal reaction on the wheel. Its value can be determined experimentally or by analytical dependencies. In this article, an analytical derivation of equation for calculating rolling resistance coefficient is given, followed by determining conditions under which this coefficient will be minimal.
Conditions for vertical pulling of semi-finished leather products under driving rollers
Authors: Nabiev Ayder , Tsoy Gerasim , Bahadirov Gayrat
Published: March 2023

The conditions for the vertical pulling of a semi-finished leather product laid bent on a transporting base plate between rotating squeezing rollers are theoretically investigated in the article for the first time. At that, an important role is played by the value of the radii of the squeezing rollers, installed in one row in the horizontal plane, and the value of the corner radius of the front part of the transporting base plate. If the value of the corner radius and the thickness of the base plate are large, then when it contacts the squeezing rollers, a significant frontal resistance arises. Thus, to derive the conditions for gripping the semi-finished leather product between the rotating squeezing rollers, the pulling-in force of the traction chains, the normal pressure force of the squeezing rollers, the coefficient of friction between the rotating squeezing rollers and the leather semifinished product are taken into account. The condition for the vertical pulling of the semi-finished leather product laid on the base plate is determined, taking into account the coefficient of friction between the semi-finished leather product and the squeezing rollers when they come into contact.
Validation of a methodology for forest industry sector sustainability assessment
Authors: Medvedev Sergey , Zyryanov Mikhail
Published: March 2023

The research is devoted to the development and testing of a methodology for assessing the level of sustainability of the forest industry. The work presents the general specifics of the methodology, the formula for calculating the sustainability index, the justification of the original approach, taking into account the specifics of the forest industry. The method is based on a system of economic, environmental and social indicators. The evaluation is based on the example of the forest sector logging sector. As a result of the approbation, it was determined that sustainability of forest industry development is below average in most regions of the country. The proposed methodology can be used as a justification for the necessity of transformations in the forest industry sector. This direction of industry is recognized as one of the underestimated and perspective in the sphere of modern requirements of the society to development of economy. The activity of the forest industry is associated with both timber production (deforestation) and reforestation. This makes it a unique industry. By using renewable resources in production, the industry can be seen as truly capable of adopting and implementing sustainable development. As a consequence, studies aimed at evaluating the various projects related to sustainable development in the forest industry are highly relevant.
Verification methods for complex-functional blocks in CAD for chips deep submicron design standards
Authors: Zolnikov Vladimir , Zolnikov Konstantin , Ilina Nadezhda , Grabovy Kirill
Published: March 2023

The article discusses the design stages of very large-scale integrated circuits (VLSI) and the features of the procedure for verifying complex-functional VLSI blocks. The main approaches to microcircuit verification procedures are analyzed to minimize the duration of verification cycles. In practice, a combination of several approaches to verification is usually used.
Possibilities of information technologies in the processes of designing efficient processes for the production of aircraft structures
Authors: Bekhmetiev Vyacheslav , Safoklov Boris , Gusev Pavel , Aleksandrovskiy Maxim
Published: March 2023

The work presents the process of studying CAD- Systems and systems of technological automated design of elements of aviation structures in serial production of aviation equipment. It has been established that the most important goal of laying CAD systems is to create a single information space, which It involves the rejection of direct interaction and data transfer between all participants in the product life cycle, which is implemented in the system of automated design "Vertical".
History and development prospects of silk farming in Uzbekistan
Authors: Nasirillaev Bakhtiyar , Rajabov Narzulla , Abdukadirov Murodkhuja , Fozilova Khurshida
Published: March 2023

Mulberry silkworm seeds were smuggled to Central Asia by a Chinese princess married to Khotan Khan in the middle of the 4th century. By the 7th century, Khotan, Kusham and other Northern Silk Industry was the main labor activity of the population in the provinces of Turkestan. In the 7th century, as a result of the introduction of the technology of cocooning and gazlam weaving by Marv merchants for commercial purposes from Persia, it became more widespread in the territory of Central Asia. Uzbekistan is a country with a long history among the world's developed silk industry. Mulberry silkworm seeds entered Central Asia through the Khotan province in the middle of the 4th century, and have become one of the main occupations of the population until now. This article analyzes the history of sericulture in Uzbekistan, stages of development, and achievements in the field of research and production. It is planned to increase the total area of mulberry plantations in Uzbekistan from 48,720 hectares in 2019 to 77,422 hectares by 2021, and the number of individual mulberry rows to 79 million 515 thousand bushes. It is also planned to increase the number of boxes of silkworms from 350,000 boxes to 500,000 boxes, from 19,607 tons to 30,000 tons.
Development of a New Blended Fabric on the RIFA-RFJW-10 Machine and Performance Analysis
Authors: Khamrayeva Sanovar , Mirzanazarova Dilbar , Nazarova Dilrabo
Published: March 2023

Effective condition for obtaining high-quality underwear fabrics with the required physical and mechanical properties is the formation of tissues of the required structure and structure. It should be noted that it is the improvement of the structure parameter and the change in tissue structure that makes it possible to improve them in the first place. In this article, it is stated that one of the textile products necessary for the daily life of the people of the whole world is bed linen, that there is a lot of demand for it, that it is widely used by all people regardless of the conditions, and the requirements of physical-mechanical, hygienic and technological characteristics are given to them. In addition, it is noted that fabrics intended for bed linen should be woven in linen or satin weaves, linens in linen weave should be light, soft and have an uneven surface, and sheets in satin weave should be smooth, coolness and air permeability are lower than linen, but they are pleasant in the process of relaxation. The results of an experimental study conducted at the "Urgut Textile" enterprise, comparing 100% polyester fabric with 100% polyester, 40% hemp yarn and 60% cotton fabric, are presented.
Theoretical study of the influence of the changing environment on the process of rainfall irrigation
Authors: Khudayorov Zafar , Khalilov Rakhmonberdi , Mirzakhodjaev Sherzodkhuja , Nurmikhamedov Buron , Mamasov Shavkat
Published: March 2023

The technology of sprinkler irrigation has a higher coefficient of land use compared to that of regular irrigation, due to the absence of irrigation erosion, the prevention of unnecessary absorption of water into the soil, the high degree of mechanization and automation of the irrigation process, the saving of equipment and fuel costs, the availability of irrigation in areas with uneven relief, the uniform moistening of the root layer. It has the advantage of achieving the same growth and development of the plant in all parts of the field. At the same time, there are opportunities to achieve savings as a result of giving mineral fertilizers in the form of suspension during irrigation. This article examines the distribution of water droplets on the field surface during sprinkler irrigation and the influence of wind speed on the intensity of irrigation. Water drop motion and wind motion were analyzed in one coordinate system. As a result, a mathematical model of the resistance coefficient of the environment and the movement of a water droplet in a variable environment was developed.
Provision of remote methods for estimating soil salinity on meliorated lands
Authors: Isaev Sabirjan , Bekmirzaev Gulom , Usmanov Mirkadir , Malikov Elyor , Tadjiev Sunnat , Butayarov Abdukadir
Published: March 2023

The proposed methodological recommendation on the ground support of remote methods for assessing salinization of soil in reclaimed lands is devoted to the operational monitoring of salinity of reclaimed lands. The assessment and forecasting of cotton yield in the Hungry Steppe and the lower reaches of the Amu Darya, by direct signs of determining salinity at farms, a separate irrigated plot, based on remote information (aerial and space photography - APS and KFS). The task of the under investigations study is visual assessment of soil salinity level by indirect signs: condition of crops, fall of plants, salt bloom, etc. The results of the established check are recorded in the field journal. Salinity map with salinity contours; slightly saline, moderately saline and strongly saline soils are created based on the studied research materials. Number and location of the main sites for determination of soil salinity features are determined on the basis of analysis of the research materials determined with involvement of other available materials on the soil cover characteristics. Classification of soils according to the degree of salinity is carried out according to the formula WP = PVU + VJp; WP = 51.42 - 96.28 Jp ± 1.12 g ha-1. It is presented in Table 2 for Amu-Darya lower reaches (Khorezm province and the Republic of Karakalpakstan), where + Y - yield calculation; PVU - maximum yield. This program is designed for use in the educational process during practical lessons on agricultural reclamation directions.
Importance of humine preparation and organic fertilizers in improving the fertility of eroded typical gray soils
Authors: Makhkamova Aliya , Kamilov Bobir
Published: March 2023

In the world, scientific work is being carried out in a number of priority directions on maintaining, restoring, and increasing soil fertility, as well as returning plant residues to the soil, minimal processing, and the preparation and use of organic fertilizers from household waste. In this regard, special attention is paid to studies aimed at optimizing the agrophysical, agrochemical and other properties of soils based on the soil-climatic conditions of the regions, developing agro-measures based on the soil-climatic conditions of each region, restoring, maintaining and increasing soil fertility. Effective use of land, water and other natural resources, providing the population with ecologically clean and high-quality products, maintaining and increasing soil fertility, and using high-performance modern resource-saving technologies in the care of agricultural crops are the main tasks in Uzbekistan today. In the article, the general physical properties of irrigated gray soils distributed in Piskent district of Tashkent region, the general physical properties of nitrogen, phosphorus, potassium in the environment of humus, poultry manure, the positive effect of their use on the development of cotton crops and the amount of yield were determined.
Statistical modeling of the sea surface in the presence of abnormal waves
Authors: Zapevalov A. , Knyazkov A.
Published: March 2023

A wide range of fundamental and applied problems requires a detailed description of the statistics of abnormal sea waves (freak waves or rouge waves). These waves are characterized not only by a change in ener-gy, but also by strong nonlinearity, leading to extreme values of the higher cumulants. The possibilities and limitations of modeling the probability density function (PDF) of sea surface elevations by a two-component Gaussian mixture at extreme values of skewness and excess kurtosis are analyzed. The parameters of a two-component Gaussian mixture are calcu-lated from known values of statistical moments. Model PDFs in the form of a two-component Gaussian mixture are compared with PDFs based on direct wave measurement data, and also compared with the known Gram-Charlier distribution. It is shown that with positive values of the excess kurtosis, the PDF in the form of a two-component Gaussian mixture can be constructed at the limit values of the skewness and excess kurtosis ob-tained in different regions of the World Ocean. With large negative values of the kurtosis, the shape of the probability density function is strongly dis-torted, which indicates the limit of applicability of a two-component Gaussian mixture to the description of such situations.
CFD modeling of air exchange in a room using a textile air duct with microperforations
Authors: Agafonova Vera , Skibin Alexander , Volkov Vasily
Published: March 2023

The article is devoted to the issue of increasing the energy efficiency of ventilation systems and improving the air quality in the working environment of the premises of communication personnel for the maintenance of transport infrastructure when using a new types of air distribution devices. These include textile air ducts made of polyester. This material allows you to cut micro-holes. The advantage of diffusers with microperforation is the possibility of even distribution of air throughout the premises without creating drafts in the working area. The results of the analysis of literary sources on the issue of improving air quality in public buildings are presented. The data on the results of a comparative CFD modeling of the air distribution in the room with two supply air supply schemes: through the supply openings and with the help of a textile air duct with microperforation are presented. In the course of numerical calculation, the distribution fields of temperature and air velocity in the working area of the room were obtained. It is concluded that the textile air duct copes with the task of removing excess heat more efficiently than the traditional ventilation system.
Retracted Article: Effects of bulk cargo displacements on changes in truck axle loads
Authors: Scherbakov Alexander , Pushkarev Alexandr , Kuzmin Oleg , Vinogradova Tamara , Petrov Andrey
Published: March 2023

This paper has been formally retracted on ethical grounds because the article contains
extensive and repeated instances of plagiarism. The authors are responsible for this
mistake and apologise for it. Request approved by the proceedings Editor and the
Publisher on September 13, 2023.
Analysis of the movement of an empty railcar on the longitudinal profile of the sorting slide
Authors: Saidivaliev Shukhrat , Sattorov Samandar , Tursunkhodjaeva Rashida , Abdullaev Rustam
Published: March 2023

The article uses analytical formulas derived from the application of the basic law of dynamics for non-ideal connections (the Dalembert principle), the calculation of the kinematic parameters of the rail carriage movement (acceleration, time, braking path) in the braking zone on the site of the first braking position of the sorting slide is performed. All over the world, it is becoming increasingly important to design and build modern sorting stations, as well as to choose the right height for sorting slides. The main function of the sorting slide at railway stations is the disbanding of trains, as well as the formation of new trains. Sorting will depend on how rationally the profile of the descending part of the slide is designed. Calculation of the height of the descending part of the slide and design work is carried out according to the existing method, according to which the movement of the railcar on the slope of the sorting slide, the speed is determined by the expression of the rate of fall of the railcar vertically, taking into account the inertia of the rotating masses. This, in turn, creates several problems. In developed countries, including the US, Germany, Sweden, China, India, and Russia much attention is paid to the development of methods, such as mechanization and automation of sorting ways of stations that affect haul transport and local rail network [1-7].
Methodology for assessing the tax security of the state using mathematical modeling methods
Authors: Reutov Victor , Vorobyova Elena , Apatova Natalia , Borsch Lyudmila , Burkaltseva Diana , Blazhevich Oleg , Kravchenko Ivan , Plaksa Julia
Published: March 2023

The issues of studying tax security are especially relevant and important from the point of view of the problem of ensuring the security of
the country as a whole, as a tool for managing socio-economic systems and ensuring social protection of the population. The purpose of the study is to study the indicators of the tax security of the Russian Federation, taking into account threats. The article clarifies the essence of the concept of •tax security•; assessed the tax security of the Russian Federation on its main aspects; Threats to Russia’s tax security have been identified and systematized. The analysis of modern economic literature revealed the following problems in the study of this topic: some authors consider it as an independent type of security, others - as an integral part of budgetary and tax security; there is also no well-developed comprehensive methodology for assessing tax security; At the same time, the study of threats to tax security takes place without studying the causes of their occurrence and the consequences to which they lead.
The role of technological innovations in institutional regulation of the financial capital market
Authors: Abuzov Artur
Published: March 2023

Financial technologies (fintech) have been actively developing in recent years and are overturning conventional notions about the financial capital market. The article explores the role of technological innovations in institutional regulation of the financial capital market. Thanks to innovations such as blockchain technology, artificial intelligence, and machine learning, market participants are able to make more accurate and faster decisions, ensure transaction security and reliability, and have more transparent and efficient risk management. The article describes some examples of successful implementation of technological innovations in institutional regulation of the financial capital market, such as the use of blockchain in supply chain management, automation of risk management, and real-time processing of large volumes of data. A mathematical model of optimal institutional regulation of the financial capital market is presented. However, in addition to the advantages, the use of technological innovations also carries potential risks such as breach of confidentiality, incomplete information of market participants, and the possibility of technological glitches. Therefore, it is important to develop and effectively implement measures to regulate the use of fintech, which must comply with rules and legislation.
Finite element approximation of dielectrophoretic force driven flow problems
Authors: Gerstner Philipp , Heuveline Vincent
Published: March 2023

In this paper, we propose a full discretization scheme for the instationary thermal-electro-hydrodynamic (TEHD) Boussinesq equations. These equations model the dynamics of a non-isothermal, dielectric fluid under the influence of a dielectrophoretic (DEP) force. Our scheme combines an H1-conformal finite element method for spatial discretization with a backward differentiation formula (BDF) for time stepping. The resulting scheme allows for a decoupled solution of the individual parts of this multi-physics system. Moreover, we derive a priori convergence rates that are of first and second order in time, depending on how the individual ingredients of the BDF scheme are chosen and of optimal order in space. In doing so, special care is taken of modeling the DEP force, since its original form is a cubic term. The obtained error estimates are verified by numerical experiments.
Complete Resolution of Peptic Ulcer by Individualised Homoeopathic Anti-Miasmatic Treatment—A Case Report
Authors: Raizada Sonia , Shukla Indu
Published: March 2023

Peptic ulcer is a lifestyle disorder and is becoming very common nowadays. A dull or burning pain in abdomen is the most common symptom of a peptic ulcer. Less common symptoms may include bloating, burping, poor appetite, vomiting and weight loss. Conventional treatments of peptic ulcer, such as proton pump inhibitors and histamine-2 receptor antagonists, have demonstrated adverse effects, relapses and various drug interactions. Homoeopathy offers an effective and safe treatment of cases through its unique holistic approach and can prevent surgery. The case reported here is of peptic ulcer in a 70-year-old male presenting with burning pain and bloating in abdomen along with regurgitation of food. Endoscopy showed multiple erosions with deep ulcers at pyloric opening and in the duodenum. He was successfully treated as evident by subsequent radiological study by anti-miasmatic individualised homoeopathic treatment with single medicine Phosphorus. It has been observed that apart from healing of the ulcer, the general health of the patient also improved with homoeopathic treatment.
A Commoner at an Extremely Rare Site: A Case of Dorsal Intramedullary Spinal Dermoid Cyst
Authors: Prachi Prachi , Aiyer Hema Malini , Sharma Gaurav , Shrivastav Ashish Kumar
Published: March 2023

Intramedullary dorsal dermoid cysts are rare benign tumors, arising from the nests of embryonic ectoderm, which get buried or trapped under the lines of fusion of the ectodermal folds in the developing embryo. We present a rare case of intramedullary dermoid cyst in a 30-year-old asymptomatic female, who presented with paraplegia and ataxia. Magnetic resonance imaging was suggestive of neoplastic intramedullary mass. Intraoperatively, findings were suspicious of tuberculosis, but on final histopathological evaluation, the final and definitive diagnosis of intramedullary dermoid cyst was rendered. The postoperative phase was uneventful.