bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving cervical cancer screening participation by introducing HPV vaginal self-sampling to women living with HIV in Denmark – a cross-sectional study
Authors: Svensgaard Siri Nana Halling , Tranberg Mette , Andersen Berit , Petersen Lone Kjeld , Storgaard Merete , Jespersen Sanne
Published: October 2024

Background:
Cervical cancer, despite being largely preventable through vaccination and screening, continues to pose a significant global health challenge. Women living with HIV (WLWH) are at a six-fold higher risk of developing cervical cancer, primarily due to persistent infection with high risk HPV (hrHPV). While effective screening methods have the potential to reduce this risk, WLWH remain inadequately screened.
The aims of this study were fourfold: To estimate the proportion of WLWH who are not screened according to WHO guidelines; to establish the proportion of WLWH who accepted the self-sampling offer; to estimate the hrHPV DNA prevalence; and to estimate the compliance to follow-up among women with a hrHPV-positive vaginal self-sample.
Methods:
This single-centre, cross-sectional study was conducted from February to May 2022 at the Department of Infectious Diseases, Aarhus University Hospital, Central Denmark Region. Eligible women were contacted by phone and invited to participate. Participants were provided with a self-sampling kit and detailed instructions. The collected samples were analysed for hrHPV DNA. Demographic, clinical, and screening history data were obtained from medical records and the Danish Pathology Databank.
Results:
Of the 100 eligible participants, 50 (50%) accepted the offer of self-sampling, and 40 (80%) returned their samples for analysis. The prevalence of hrHPV among these women was 25%. Follow-up compliance among hrHPV-positive women was 40%. The analysis revealed that 42% of WLWH had not been screened in accordance with WHO guidelines, and 18% had never undergone screening. No significant differences were observed in demographic or clinical characteristics between participants and non-participants.
Conclusions:
Our study highlights a substantial gap in cervical cancer screening among WLWH. Although home-based hrHPV self-sampling was well-received, overall participation and compliance to follow-up HPV-screen positive were insufficient. To improve cervical cancer prevention, more personalized and clinic-based screening strategies, combined with enhanced follow-up procedures, are essential. Addressing these barriers is critical to improving health outcomes and reducing the incidence and mortality of cervical cancer among WLWH.
Trial registration:
The Central Denmark Region Committee on Health Research Ethics deemed this study as a quality improvement study on the 9th of November 2021 (request approval j.no: 204/1-10-72-274-21). Clinical trial number: Not applicable.
Surgical Training Outcomes Using a Mixed Reality Combination System
Authors: Kabuye Ernest , Bone Jennifer , Hudson Andrew , Feinberg Adam , Sangimino Mark , Cagan Jonathan , LeDuc Philip
Published: October 2024

A significant number of medical errors are surgical, when patients are in the operating room, and are also a prominent cause of death. Prior work introduced a Mixed Reality Combination System (MRCS) that integrates Augmented Reality (AR) technology, an inertial measurement unit (IMU) sensor, and 3D-printed, collagen-based specimens to enable realistic and versatile synthetic environments for surgical training, with the goal of alleviating this issue. The MRCS creates an iterative learning scenario that allows a user to pick up a skill set in a limited time. This paper demonstrates the advantages of the MRCS technology through human subjects studies that assess its effectiveness. Results from a controlled study show that the MRCS study participants are 25% better at task execution, reach a net zero difference in expected task outcomes in 75% of the cases, and demonstrate self-confidence in their surgical skills compared to the non-MRCS study participants. A second qualitative study with medical residents demonstrates MRCS’s proposed benefit as a training tool in a medical school curriculum. This work has the potential to benefit future surgical training and surgical planning.
Cost minimization analysis between iron saccharate and ferric carboxymaltose in the treatment of iron deficiency anemia: a real life cohort study
Authors: Braga Renan Camilo , Rabello Bianca Pimentel de Andrade Barbosa , de Almeida-Neto César , Corrêa Lorena Costa , de Oliveira Fábio Henrique Cavalcanti
Published: October 2024

Background Approximately 20 to 30% of the Brazilian population is anemic. Specialized hospitals tend to serve a population with a high incidence of iron deficiency anemia, routinely administering intravenous (IV) iron therapy. Ferric hydroxide sucrose (FHS) and ferric carboxymaltose (FCM) are IV iron compounds used in Brazil. Due to differences in administration time, daily dose limits, pharmacodynamics, and vial prices, it is necessary to develop an economic feasibility analysis to better allocate resources. This study aims to deepen the discussion on public health management in economically peripheral regions such as the Northeast, addressing health economics as a strategic response.Methods This is a real-world, retrospective cohort study of cost-minimization conducted at a hospital specialized in gynecology and obstetrics in Northeast Brazil. A total of 834 records of IV iron usage were evaluated from 09/13/2022 to 04/25/2024, with this sample selected for convenience. All patients underwent treatment for iron deficiency anemia with FCM or FHS. The acquisition cost per vial for FCM and FHS was $97,69 and $1,82, respectively. Among the variables computed, following economic evaluation guidelines, were vial cost, infusion cost, outpatient consultation, daily medical clinical hospitalization cost, and follow-up cost, based on the institution's actual costs and national databases.Results Of the 834 records, 644 were for FHS and 190 for FCM. A total of $37.124,69 was spent on acquiring FCM and $11.766,77 on FHS. The minimum individual cost for treating iron deficiency anemia is $257,90 for FCM and $641,07 for FHS. The cost of treating 644 patients with FHS was $412.849,08, while the estimated cost of treatment with FCM for the same 644 patients would be $166.087,60.Conclusion Treatment of iron deficiency anemia with FHS proved to be approximately 148% more expensive. The use of FCM leads to cost reductions, allowing for better allocation of public financial resources, as well as shorter hospitalization times and fewer invasive procedures.
The utility of individualized interactive 3D virtual models for improving patient and resident education in robotic partial nephrectomy
Authors: Hochberg Aaron R. , Raghavan Rajiv , Monane Rachel , Belko Sara , Lavine Isabel B. , Im Brian H. , Dispagna Mauro , Pugliese Robert , Lallas Costas D.
Published: October 2024

Introduction:
Robotic partial nephrectomy (RAPN) requires careful planning due to high anatomical variability between patients presenting challenges during counseling on the surgery, anatomy, and risks. 3D digital modeling provides an opportunity to address this issue. Prior studies predominantly investigate the use of 3D printed models which have limitations including cost. This study seeks to assess the utility of an individualized interactive 3D virtual model for patient counseling and surgical trainee education for RAPN.
Methods:
Patient-specific virtual 3D models were derived from imaging of 32 patients to undergo RAPN at Thomas Jefferson University Hospital between October 2023 and April 2024. Patients filled out surveys pre and post model exposure to assess their understanding of their kidney, pathology, the surgery, and its risks. Surgical trainees filled out pre and post model surveys and post-operative surveys to assess the impact of the model on surgical understanding and patient counseling.
Results:
Patient understanding of their kidney, pathology, and surgery all significantly improved after viewing the model (p < 0.05) Both patients and trainees found the model to be helpful (averaging > 9 out of 10) across all assessed domains of patient counseling and education. The model was not found to be significantly associated with improved trainee confidence in anatomy and surgical planning.
Conclusion:
This study shows that an interactive 3D virtual model is a useful adjunct to patient education prior to RAPN from both the patient and provider experience and can serve as a less resource-intensive alternative to 3D printed modeling for this application.
Timely reduction of triglyceride in patients with different severity of hypertriglyceridemia-associated acute pancreatitis：secondary analysis of a multicenter, prospective cohort study
Authors: Luo Xiang , Li Xiaoling , Lai Xiaoyan , Mao Wenjian , Ke Lu , Fu Lingyan , Gao Lin , Liu Yaolu
Published: October 2024

Objectives
It is controversial whether rapid lowering of triglyceride (TG) levels was associated with clinical benefits in patients with hypertriglyceridemia-associated acute pancreatitis (HTG-AP). Particularly, patients with different severity of disease may respond differently to TG-lowering therapy. In this study, we aimed to explore the association between timely reduction in serum TG levels and organ failure in patients with different severity of HTG-AP.
Methods
This is a secondary analysis of data from a multicenter, prospective registry recruiting HTG-AP patients (plasma TG levels > 11.3mmol/L at admission) admitted within 72 hours from the onset of symptoms. Patients were dichotomized into either target reaching (TG ≤ 5.65 mmol/L on study day 3) or not. The primary outcome was the presence of organ failure on day 14. The association between target-reaching and the primary outcome was modelled. Furthermore, subgroup analyses were conducted based on the disease severity of HTG-AP patients at enrollment (with vs. without organ failure, predicted severe vs. predicted non-severe based on APACHEII score).
Results
Overall, 413 patients were included for analysis, of whom 192 (46.5%) patients reached the target on day 3. For the overall study cohort, there was no significant difference in presence of organ failure at day 14 between patients reaching the target or not (3.1% vs. 6.8%, p = 0.091). In the subgroup of HTG-AP patients with organ failure at enrollment, compared to patients with TG > 5.65mmol/L on day 3, patients who reached the target had significantly lower presence of organ failure at day 14 (7.8% vs. 22%, p = 0.039), and the results remain unchanged after adjustment for potential confounders (p = 0.027). In the subgroup of more severe HTG-AP patients (APACHE II ≥ 8), there was also lower presence of organ failure at day 14 (5.8% vs. 17.7%, p = 0.044) and lower incidence of IPN within 60 days (1.4% vs. 11.3%, p = 0.036) in patients who reached the target.
Conclusion
Timely reduction of serum TG levels was associated with decreased presence of organ failure at day 14 in patients with more severe HTG-AP.
Three-dimensional heterogeneity of smooth muscle fiber density anterior to the rectum in males: Quantitative analysis with implications for transanal total mesorectal excision
Authors: Muro Satoru , Tharnmanularp Suthasinee , Tsukada Yuichiro , Ito Masaaki , Nimura Akimoto , Akita Keiichi
Published: October 2024

Purpose
Transanal total mesorectal excision for rectal cancer in men poses a risk of urethral injury. The morphology of smooth muscle tissues around the rectum is reportedly characterized by differences in fiber density; however, quantitative analysis of these tissues for surgical applications is lacking. This study aimed to quantitatively analyze the histological properties of fiber density and the spatial extent of the smooth muscle anterior to the male rectum.
Method
This descriptive cadaveric study involving six adult cadavers was conducted at Tokyo Medical and Dental University. Serial histological sections were prepared from tissues in the region anterior to the rectum, and immunostaining and three-dimensional reconstruction were performed to evaluate the spatial distribution of the smooth muscle. Smooth muscle fiber densities were measured in different regions of the smooth muscle anterior to the rectum and statistically analyzed.
Results
The three-dimensional heatmap revealed a gradual change in fiber density within the smooth muscle anterior to the rectum, with a low density in the superior part and a high density in the inferior part. In mid-sagittal immunostained sections, the smooth muscle anterior to the rectum exhibited a significant difference in fiber density, averaging 23.22% ± 5.50% in the superior area and being significantly higher at 46.99% ± 12.92% in the inferior area.
Conclusion
Heterogeneity in fiber density between the superior and inferior smooth muscle anterior to the rectum suggests that these differences could serve as landmarks, providing crucial positional information to avoid urethral injury during transanal total mesorectal excision.
Machine Learning Models for Predicting ICU Admission and Mortality in Pediatric Severe Clinical Pneumonia: A Cohort Study
Authors: Xu Chushi , Zhang Yao , Yang Hua , Xu Kaili , Tarokhian Aidin
Published: October 2024

Purpose
Pneumonia remains a leading cause of morbidity and mortality among children worldwide, especially in low- and middle-income countries. This study explores the application of machine learning (ML) models to predict ICU admission and mortality in pediatric patients with severe pneumonia.
Methods
This study utilized a dataset, comprising 801 patients with acute respiratory presentation at the Children's Hospital of Rabat, Morocco. Patients meeting WHO criteria for severe pneumonia were included, excluding those who left against medical advice, resulting in 699 patients. Four ML algorithms were employed. Feature selection was performed to identify the top five features influencing ICU admission and mortality.
Results
The support vector model had a positive likelihood ratio (PLR) of 9.333 (95% CI: 5.181–16.810) and a negative likelihood ratio (NLR) of 0.309 (95% CI: 0.120–0.794), the logistic regression model showed a PLR of 9.625 (95% CI: 5.590–16.574) and an NLR of 0.233 (95% CI: 0.086–0.637), the Gaussian naive Bayes model had a PLR of 7.000 (95% CI: 3.886–12.608) and an NLR of 0.393 (95% CI: 0.194–0.795), and the XGBoost model demonstrated a PLR of 32.84 (95% CI: 8.333–129.47) and an NLR of 0.508 (95% CI: 0.250–1.030) for predicting ICU admission. For predicting mortality, the support vector model showed a lower accuracy. Cyanosis was the most important factor for both ICU admission and mortality.
Conclusion
ML models demonstrate high accuracy in predicting ICU admission but lower reliability for mortality prediction.
Integrated ctDNA Methylation Profiling of P2RX1, CBFA2T3, and CERS4 as Pancreatic Ductal Adenocarcinoma Biomarkers: Identification and Mechanistic Insights
Authors: Chen Hongsheng , Shen Hongyuan , Wang Xudong , Ju Shaoqing , Pu Weilin , Zhang Jianfeng , Ding Weifeng
Published: October 2024

Background: Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most formidable cancers globally, yet its diagnosis continues to be a pressing challenge, largely owing to the inherent limitations of current diagnostic methodologies.
Methods: Utilizing whole-genome bisulfite-sequencing (WGBS), differentially methylated genes in the promoter region were identified from the plasma of PDAC patients. Subsequently, screening of candidate methylation genes, methylation-specific primers and probes for P2RX1, CBFA2T3 and CERS4 were designed, and a stable multiple quantitative methylation-specific polymerase chain reaction (M-QMSP) system was established to detect the circulating tumor DNA (ctDNA) methylation level of these genes in PDAC. Finally, the disease-driving mechanism of the biomarker CERS4 was explored separately in vitro and in vivo.
Results: A total of 112,294 differential methylation regions (DMRs) were precisely identified by WGBS, encompassing 88,210 hypermethylation DMRs and 24,084 hypomethylation DMRs. Notably, three differentially methylated genes, P2RX1, CBFA2T3 and CERS4 (nominated as P2CC model), were astutely pinpointed as potential plasma methylation biomarkers. The M-QMSP system was established through the prioritization of these genes, which demonstrated that the combined diagnostic prowess of P2CC modelnotably outperformed carbohydrate antigen 19-9 (CA19-9). In PDAC, overexpression of CERS4 has been observed to suppress tumor growth in nude mice xenografts and inhibit cell proliferation and migration. Additionally, CERS4played a pivotal role in promoting lipid metabolism.
Conclusion: Based on WGBS screening and M-QMSP validation, we have determined that the P2CC model can serve as the combined diagnostic biomarkers for PDAC, superior to CA19-9. Moreover, as a tumor suppressor gene, CERS4regulates the metabolism of sphingolipids.
Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages
Authors: Auburn Sarah , Kleinecke Mariana , Rumaseb Angela , Sutanto Edwin , Trimarsanto Hidayat , Hoon Kian Soon , Osborne Ashley , Manrique Paulo , Peters Trent , Hawkes David , Benavente Ernest Diez , Whitton Georgia , Siegel Sasha , Pearson Richard , Amato Roberto , Rai Anjana , Thuy-Nhien Nguyen , Nguyen Hoang Chau , Assefa Ashenafi , Degaga Tamiru , Abate Dagimawie , Rahim Awab , Pasaribu Ayodhia , Sutanto Inge , Alam Mohammad Shafiul , Pava Zuleima , Mesa Tatiana Lopera , Echeverri Diego , William Timothy , Anstey Nicholas , Grigg Matthew , Day Nicholas , White Nicholas , Kwiatkowski Dominic , Noviyanti Rintis , Neafsey Daniel , Price Ric
Published: October 2024

The elimination of Plasmodium vivax is challenged by dormant liver stages (hypnozoites) that can reactivate months after initial infection resulting in relapses that enhance transmission. Relapsing infections confound antimalarial clinical efficacy trials due to the inability to distinguish between recurrences arising from blood-stage treatment failure (recrudescence), reinfection or relapse. Genetic relatedness of paired parasite isolates, measured by identity-by-descent (IBD), can provide important information on whether individuals have had single or multiple mosquito inoculations, thus informing on recurrence origin. We developed a high-throughput amplicon sequencing assay comprising 93 multi-SNP (microhaplotype) P. vivax markers to determine IBD between P. vivax clinical isolates. The assay was evaluated in 659 independent infections from the Asia-Pacific and Horn of Africa, including 108 pairs of infections from a randomized controlled trial (RCT). A bioinformatics pipeline (vivaxGEN-MicroHaps) was established to support data processing. Simulations using paneljudge demonstrated low error in pairwise IBD estimation in all countries assessed (all RMSE <0.12) and IBD-based networks illustrated strong clustering by geography. IBD analysis in the RCT demonstrated a higher frequency of suspected relapses or recrudescence in patients treated with primaquine regimens (0.84) compared to those without primaquine (0.60). Our results demonstrate the potential to derive information on P. vivax IBD using amplicon sequencing, that informs policy-relevant treatment and transmission dynamics.
Epidemiological studies on the incidence of papaya ringspot disease under Indian sub-continent conditions
Authors: U PREMCHAND , Mesta Raghavendra K. , Basavarajappa Mantapla Puttappa , Venkataravanappa Venkataravanappa , Reddy Lakshminarayana Reddy C. Narasimha , Shankarappa Kodegandlu Subbanna
Published: October 2024

Papaya (Carica papaya L.) is a commercially important fruit crop cultivated worldwide due to its nutritional and medicinal values. Papaya ringspot disease (PRSD), caused by the papaya ringspot virus (PRSV), poses a significant threat to papaya cultivation, resulting in substantial yield losses. In this study, two independent field experiments were conducted at Bagalkote located in the Northern Dry Zone of Karnataka. The first experiment aimed to determine the optimal planting month for papaya to effectively manage PRSV disease. The second experiment aimed to determine the susceptibility stage of papaya to PRSV infection. The results revealed that planting papaya in March was identified as the best month for planting, as it exhibited the lowest disease incidence along with superior growth and yield characteristics compared to other planting months. On the other hand, planting during the winter season (September to January) resulted in high disease severity due to an increased aphid population. Conversely, planting during the low aphid population period (spring season) delayed disease incidence until the monsoon. By the time the aphid population starts to increase, the plants have already passed the flowering and fruit-bearing stages. In the second experiment, the severity and frequency of foliar symptoms on PRSV-inoculated papaya plants were significantly higher in plants inoculated at the early growth stage compared to those inoculated at a later growth stage. This suggests that the early crop growth stage (up to 180 days after transplanting) is a critical period for PRSV infection, and effective disease management measures should be implemented during this time to control the spread of the disease and improve growth and yield parameters. Additionally, plants inoculated at an early stage had a higher viral titer, more severe symptoms, and a higher percent transmission rate compared to those inoculated at a later stage, demonstrating a highly significant and positive correlation using qRT-PCR.
Synthetic Lethality Through GSK3 Inhibition in Glioma Stem Cells via the WNT-WWC1-YAP Axis
Authors: Chen Jian , Ren Fangfang , Yi Yulan , Lu Ting , Liu Xinze , Cui Gang , Huang Song , Parada Luis
Published: October 2024

Glioblastoma (GBM) is an aggressive brain tumor driven by glioma stem cells (GSCs), which contribute to tumor growth and therapeutic resistance. This study investigates the effects of GSK3 inhibition on GSC viability, focusing on the role of the canonical WNT signaling pathway. We found that GSK3 inhibition activates the WNT pathway, leading to upregulation of Wwc1, which downregulates Yap via LATS1 phosphorylation. This reduces GSC proliferation, self-renewal, and enhances chemosensitivity. Analysis of clinical datasets revealed that WNT pathway activation correlates with improved prognosis in proneural gliomas, particularly in IDH1-mutated tumors. Our findings suggest that targeting the WNT-Wwc1-YAP axis, particularly through GSK3 inhibition, could induce synthetic lethality in GSCs and provide a promising therapeutic strategy for gliomas. These results highlight the potential of exploiting WNT-induced synthetic lethality as a novel approach for glioma treatment.
Molecular dynamics simulation of microscopic deformation of cross-linked isoprene rubber networks
Authors: Zhang Zelin , Wei Zhigang , Wu Hao , Zuo Junjie
Published: October 2024

Molecular dynamics analysis is wildly used to investigate the interaction between molecular chains, comprehensively and intuitively reveal the structure of a network and its deformation characteristics. The use of molecular dynamics can reveal the relationship between microstructural changes and macroscopic deformations of materials, which has an important impact on the mechanical properties of rubber. Using molecular dynamics simulation, three coarse-grained models of isoprene rubber (IR) with different degrees of cross-linking were established and subjected to uniaxial stretching. The positions of the effective cross-linking points in the cross-linked IR network during deformation were derived, and compared with their corresponding affine deformation positions. It is found that the average deviation value of cross-linked IR crosslinking points in the stretching direction is larger than that in the lateral directions. The larger the degree of crosslinking, the stronger the macroscopic affine relationship of the crosslinking points. The relative deviation increases with the increase of the stretching rate, and the relative deviation perpendicular to the stretching direction is larger than that in the stretching direction. The end-to-end distances of the single molecular chains in the IR molecular chain network are compared with the end vectors and their affinities to search for cross-linked IR macroscopic deformation versus the microscopic deformation of the cross-linked network. It is found that the length deviation of the cross-linked IR end-to-end distances from the affine deformation in the stretching direction under uniaxial stretching is larger than that perpendicular to the stretching direction; and the direction deviation of the end vector direction from the affine deformation in the stretching direction is larger than that in the stretching direction.
Understanding the effects of oxytocin receptor variants on OXT–OXT receptor binding: A mathematical model
Authors: Dubey Preeti , Fang Yingye , Tukei K. Lionel , Kuila Shobhan , Liu Xinming , Sahota Annika , Frolova Antonina I. , Reinl Erin L. , Malik Manasi , England Sarah K. , Imoukhuede Princess I.
Published: October 2024

Approximately half of U.S. women giving birth annually receive Pitocin, the synthetic form of oxytocin (OXT), yet its effective dose can vary significantly. To address the need for improved dosing, we developed a data-driven mathematical model to predict OXT receptor (OXTR) binding. Our study focuses on five prevalent OXTR variants (V45L, P108A, L206V, V281M, and E339K) and their impact on OXT–OXTR binding dynamics in human embryonic kidney cells (HEK293T), commonly used in experimental systems, and human myometrial smooth muscle cells, containing endogenous OXTR trafficking and signaling machinery. We parameterized the model with cell-specific OXTR surface localization measurements, which were experimentally derived, and with cell-specific OXT-OXTR binding kinetics, which were derived from the literature (e.g., myometrial OXT-OXTR Kd = 1.6 nM, kon = 6.8 × 105 M− 1 min− 1, and koff = 0.0011 min− 1). Our model predicted differences between HEK293T cells and myometrial cells and recapitulated significant effects of genetic variants of OXTR. The model also demonstrated the potential for rescuing the attenuated cell response observed in V281M and E339K variants by increasing the OXT dosage at specific, early time points. In summary, our study provides a computational framework for precision oxytocin dosing strategies, paving the way for personalized medicine.
Secure Mobile Authentication With Blockchain
Authors: Ajlouni Naim , COSKUN Vedat , KOSE Busra OZDENIZCI
Published: October 2024

The increasing reliance on smartphones for sensitive transactions has underscored the urgent need for robust authentication methods in mobile applications, especially in sectors such as finance and legal services. Traditional authentication mechanisms frequently fail to meet high-security standards due to inadequate integration of advanced biometric credentials. This paper presents a Blockchain-based Three-Factor Authentication (BC-3FA) system that enhances mobile security by integrating PIN/passwords, one-time passwords (OTPs), and biometric data through advanced cryptographic techniques, including Elliptic Curve Cryptography (ECC), Zero-Knowledge Proofs (ZKPs), and Post-Quantum Cryptography. By employing Distributed Ledger Technology (DLT) for the secure storage of encrypted user credentials, the BC-3FA system not only improves security but also safeguards user privacy. The model addresses the key elements of knowledge, possession, and inherent user traits, significantly strengthening user authentication. A thorough complexity analysis indicates that ECC is optimal for mobile environments due to its low computational overhead, while the shuffling mechanism operates with a complexity of O(n log n), making it feasible for mobile devices. Additionally, NIZKs and Bulletproofs ensure efficient ZKP processes, and while Post-Quantum ZKPs offer necessary future-proofing against quantum threats, they may require further optimization for practical use on mobile platforms. The implementation of the BC-3FA model demonstrates its effectiveness and reliability in enhancing mobile service security through comprehensive testing and validation in real-world scenarios. This study provides a comparative analysis with existing solutions and identifies avenues for future improvements, establishing the BC-3FA model as a robust and innovative approach to contemporary authentication challenges in the digital landscape.
Is an extrovert actually creative? An investigation in VR on the relationship between explicit and implicit indices of creativity and personality traits
Authors: Lucifora Chiara , Gangemi Aldo , Vicario Carmelo M. , Scorolli Claudia
Published: October 2024

The connection between personality and creativity has captured the interest of the scientific community, showing controversial results about the specific personality traits that are able to influence the human creativity. To better investigate this relationship, our study employees both explicit measures such as self-report questionnaires about personality, creativity and emotions and implicit measures, we utilize a virtual reality environment in which users can create artistic artworks, enabling us to conduct an ontological analysis on the virtual artworks. The aim of our study is twofold, on one side we want to assess the correlation between scores on personality traits and creativity traits; on the other side we want to explore how personality traits may influence user’s creative skills, during a creative task in VR. Our findings support previous studies about the relationship between extroversion, agreeableness, conscientiousness, openness and creativity; and they also reveal new insights about the influence of personality on the artistic skills of the subjects.
Rechtskreiswechsel für Geflüchtete aus der Ukraine
Authors: Krasnitski Anastasia
Published: October 2024

Der Umgang mit Geflüchteten aus der Ukraine unterscheidet sich in vielen Aspekten von dem mit anderen Geflüchteten – auch im Aufenthalts- und Sozialrecht. Insbesondere erhält dieser Personenkreis aktuell exklusiv einen Aufenthaltsstatus nach § 24 AufenthG. Über diese scheinbar formale Änderung hinaus unterscheiden sich auch die praktischen Sozialleistungen der Geflüchteten immens, da ihnen ein Anspruch auf (das heutige) Bürgergeld zusteht. Im folgenden Aufsatz wird untersucht, welche nationalen rechtlichen Auswirkungen der Rechtskreiswechsel hat und welche Rolle dabei das am 01. Januar 2023 geänderte SGB II unter Einführung des Bürgergeldes einnimmt. Des Weiteren wird untersucht, welche verfassungsrechtlichen Probleme mit Blick auf den allgemeinen Gleichheitsgrundsatz dabei entstanden sind und ob weiterer Handlungsbedarf besteht.
Diseño y validación de una escala de actitudes hacia líneas telefónicas de salud mental (EALTSM) para adultos colombianos
Authors: Alicandú-Rios María Corina , López León Sofía , Redondo-Altahona Laura-Sofía , Nieto-Godoy Sofía , Rodríguez Aperador Laura Juliana , Riveros Munévar Fernando
Published: October 2024

El objetivo de este estudio instrumental era diseñar y validar la Escala de Actitudes hacia Líneas Telefónicas de Salud Mental (EALTSM). Se diseñó una tabla de especificaciones para la creación del instrumento, que fueevaluada por 7 jueces expertos de distintas partes de Latinoamérica. El estudio se realizó con una muestra de 503 participantes con un promedio de edad de 29 años. Para evaluar su validez y confiabilidad, se empleóun análisis factorial exploratorio, análisis de confiabilidad y coeficientes de correlación de Pearson. Como resultado, se alcanzaron cargas, niveles y correlaciones satisfactorias en una prueba con un total de 23 reactivos distribuidos en 3 categorías: Efectividad del servicio, Recepción de ayuday Accesibilidad al servicio. Estas evidencias, basadas en el contenido y la estructura interna, denotan altos grados de confiabilidad y validez. Se sugiere su aplicación y en participantes de Colombia, como también más análisis para su completa adaptación a Latinoamérica.
AVALIAÇÃO DOS IMPACTOS AMBIENTAIS NO ATERRO SANITÁRIO DE MANHUAÇU
Authors: Cabral Juliana Regina Coelho , Huebra Patrícia da Mata , Vargas Vitor , Adão Lázaro , Lamas Lívia Paula de Almeida , Albuquerque Érica Dutra
Published: October 2024

O município de Manhuaçu é localizado em uma região produtora de café, com intenso comércio e possui um dos maiores índices do PIB do estado de Minas Gerais. No entanto, apesar do notável crescimento econômico, o município não possui políticas sustentáveis para a qualidade de vida de seus habitantes, como a disposição adequada dos seus resíduos sólidos. Assim, esse trabalho objetivou avaliar os impactos ambientais provocados pelo aterro sanitário de Manhuaçu e a disposição inadequada dos seus resíduos. Nos anos de 2011 e 2012 a pesquisa analisou o aterro sanitário desta cidade com o intuito de encontrar irregularidades na disposição final dos resíduos sólidos e verificar eventuais impactos no meio ambiente. Para a coleta de dados foi utilizada a pesquisa documental, juntamente com técnicas de observação. Foram encontradas várias irregularidades no aterro sanitário, causadas pelo descaso do gerenciamento por parte da administração pública. Observou-se que o local de disposição final dos resíduos sólidos de Manhuaçu possui características de aterro controlado e não de um aterro sanitário. O principal motivo está ligado à simplicidade estrutural do aterro controlado, entretanto, ele pode apresentar maior risco ao meio ambiente e à saúde humana e por isso deve ser monitorado. Conclui-se que o aterro sanitário de Manhuaçu está irregular e que a situação da disposição final dos resíduos sólidos causa degradações ao meio ambiente em que está inserido.
TRADUÇÃO DE TÍTULOS DE FILMES DO INGLÊS PARA O PORTUGUÊS: QUESTÕES DE LÍNGUA E MERCADO
Authors: Lamas Lívia Paula de Almeida
Published: October 2024

O presente trabalho tem como objetivo apresentar os principais meios de tradução de títulos de filmes em Inglês para o Português, examinando, a partir da perspectiva de estudiosos da técnica de tradução, como Jakobson, Derrida, Sobral e Gentzler, o papel do tradutor na construção do texto traduzido; a questão da originalidade na transposição, e os efeitos resultantes do conjunto desse trabalho.
AS ALTERNATIVAS PENAIS EM ESPAÇOS SÓCIO-CULTURAIS
Authors: Silveira Tânia Maria
Published: October 2024

Analisa a aplicação das alternativas penais em espaços sócio-culturais. A referência da análise é o “Projeto Sócio-cultural do Serviço Social e Psicológico da Vara de Execução de Penas e Medidas Alternativas da Grande Vitória – SSP/VEPEMA”, com destaque para a oficina de fotografia, enfatizando a importância da revisão da finalidade da pena e da ressocialização do condenado, à luz das bases conceituais e legais da "Política Criminal Alternativa".
GREENHOUSE GAS EMISSIONS FROM CONSTRUCTED WETLANDS FOR ANAEROBIC SLUDGE TREATMENT: EFFECT OF SEASONALITY, PLANT SPECIES TYPE, AND SLUDGE LOADING – A PRELIMINARY ANALYSIS
Authors: A. P. da Silva Diogo , P. Matos Mateus , Ribeiro de Araújo José Antônio , de A. Neves Thiago
Published: October 2024

At sewage treatment plants, sludge management remains a bottleneck, requiring efficient and cost-effective solutions for treating this solid byproduct. It is known that the presence of plants can accelerate the sludge drying process, as a result, vertically flowed constructed wetlands (VFCWs) have been evaluated as alternatives to traditional drying beds. Though, for better applicability of this technology, this study premised on evaluating greenhouse gas (GHG) emissions in VFCWs constructed for anaerobic sludge treatment. To compare GHG emissions across different seasonal conditions, three configurations were tested: four units planted with Tifton-85 grass (Cynodon spp.), four units planted with elephant grass (Cenchrus purpureus), four control units without vegetation presence, with four sludge loading rates in each configuration: 75, 100, 150, and 200 kg TS (total solids) m–2 year–1. Higher sludge loading rates led to increased methane emissions, with emissions escalating during the rainy season. Methane emissions decreased towards the end of the resting period. The presence of vegetation reduced methane emissions mainly during the resting period due to increased aeration of the units. The conditions that would provide lower GHG emissions would be with loads of up to 100 kg m–2 year–1, in units planted with Tifton grass.
La renovación de la acreditación de alta calidad en instituciones de educación superior
Authors: de Javier , Oswaldo Jorge
Published: October 2024

En esta obra se hace una lectura de los procesos de renovación de la acreditación por alta calidad de instituciones de educación superior (IES) en Colombia, teniendo como referente el nuevo institucionalismo sociológico, desde sus conceptos de mitos, lógicas e isomorfismos de las organizaciones. A partir de un ejercicio comprensivo, se busca aportar a la resignificación de tales procesos desde los supuestos epistemológicos de los estudios organizacionales, por medio de la configuración de escenarios y orientaciones emergentes de gestión y aseguramiento de la calidad, cuando las IES se asumen como organizaciones complejas que se construyen socialmente.En términos de unidades de análisis, se tomaron 24 IES, a través del análisis de contenido de igual número de resoluciones de renovación de acreditación institucional y 24 informes de autoevaluación. Así mismo, se implementó un estudio de caso instrumental para hacer lecturas en profundidad de las realidades de los procesos de acreditación, y se aplicaron cuestionarios y entrevistas a miembros del Consejo Nacional de Acreditación (CNA), pares evaluadores y líderes de oficinas de calidad en IES.El argumento central de este libro es que los procesos de renovación de la acreditación institucional por alta calidad se han abordado de manera recurrente desde racionalidades explicativas y técnico-instrumentales; desplazando la lectura crítica y transformadora de las complejidades sociales propias de las IES como organizaciones pedagógicas de naturaleza social, histórica y compleja. Por eso, es necesario resignificar los procesos de autoevaluación, acreditación y autorregulación de las IES con perspectiva a la renovación de la acreditación institucional.
Characteristics of banditry and illegal arms trafficking during the Civil War and the first post-war years in the Belgorod district of the Kursk province
Authors: Chinenov A. V. , Novoselov N. G.
Published: October 2024

Relevance. The article examines the measures of regulatory legal regulation applied by the All-Russian Central Executive Committee and the Council of People's Commissars in the field of banditry and illegal arms trafficking during the Civil War and the first post-war years. The authors studied the territorial division of the volosts of the Belgorod district of the Kursk province and the staffing of the GPU and police departments in the county, volosts and districts in the early 1920s. In accordance with the reports, an analysis of the activities of the Belgorod District police in the fight against banditry and illegal arms trafficking was carried out.

Purpose: to study the genesis of banditry and illegal arms trafficking during the Civil War and the first post-war years in the Belgorod district of the Kursk province.

Objectives: to study the characteristics of gangs and gangs that carried out their criminal activities in the region based on the analysis of migration processes that took place in the territory of Belgorod and the county in the context of the impact on crime levels during the Civil War and the first post-war years.

Methodology. The main methodological principles of the research were historicism and objectivity, and the authors adhered to general scientific methods of synthesis analysis and the historical-descriptive method.

The results of the study are theoretical and applied in nature, based on the study of archival documents, the main measures used by the law enforcement agencies of the county in the early 1920s to combat banditry and illegal arms trafficking are identified, and attention is paid to statistical reporting by the OGPU and the police in this area.

Conclusions. The conducted research has established that the law enforcement agencies of the Belgorod district of the Kursk province managed to identify the main directions, develop and apply a set of fundamental measures to combat banditry and illegal arms trafficking during the Civil War and the first post-war years on the territory of the county.
Kursk state medical institute: the first steps of formation
Authors: Korovin V. V. , Manzhosov A. N.
Published: October 2024

Relevance. One of the most important tasks of the modern education system is to improve the quality of graduate training. The degree of mastering the profession largely depends on the effectiveness of the educational process. The reform of higher education carried out in recent decades is clearly contradictory. The introduction of bachelor's and master's degrees with changing educational standards has led to a loss of achievements in personnel training. Therefore, an objective understanding of the experience of the organization of higher education is an urgent area of scientific research. The history of universities has always attracted the interest of researchers. But often, relying only on memories, the authors ignore archival documents containing clerical, administrative, methodological and personal information. The analysis of a wide range of sources based on the latest methodological approaches allows to avoid such errors. The purpose of the study is to comprehensively consider the organizational and material prerequisites for the opening, as well as to generalize the initial stage of the functioning of the Kursk State Medical Institute in the second half of the 1930s.

Objectives: to reveal the historiographical features of the research topic; to characterize the main problems associated with the organization of higher medical education in the region.

Methodology. The principles of objectivity and historicism were applied during the research. To solve the tasks set by the author, historical-genetic, historical-systemic, historical-comparative, typological, retrospective methods were used.

Results. The study and generalization of sources and historiography made it possible to clarify the history of Kursk State Medical University at its initial stage, paying attention to the distortions and inaccuracies allowed in previous publications.

Conclusions. Kursk Medical Institute played an important role in the training of medical personnel for the region and the country, especially in wartime conditions. The statements of individual authors about the personal participation of I.V. Stalin in solving a number of issues related to the opening of the university are not confirmed by documentary sources. In the early years of the institute's operation, significant educational traditions were laid, which were successfully implemented at subsequent stages of its activity.
DEEP PACKET INSPECTION USING HYBRID CLASSIFIER FOR UNKNOWN TRAFFIC FLOWS IN THE INTERNET
Authors:   Sona College of Technology, India, P Shanmugaraja , K Chokkanathan ,   Madanapalle Institute of Technology and Science, India, K Thangaraj ,   Sona College of Technology, India, P Ilanchezhian ,   Sona College of Technology, India
Published: October 2024

In this era of Internet every electronic device being manufactured comes with built-ins to connect itself with the Internet. Such electronic gadgets create a massive amount of traffic flows every second. Managing this immense Internet traffic has become an exhausting job. Classifying these massive flows of data and interpreting them has attained considerable importance in the sight of researchers and Internet Service Providers. Many methods have been presented by various researchers to address this classification issue. This paper presents a Hybrid Classifier algorithm, which is a combination of the well-known machine learning types; the supervised learning and unsupervised learning to solve this classification issue. Accurate and Efficient recognition of flows is the key to manage flows in real-time. This algorithm classifies the traffic flows into real time flows and non-real time flows. It uses the built decision support model for classifying the flows based on the target class. To further validate the classification, it applies the k-means model. A significant improvement in the classification accuracy has been obtained.
M/G/1 QUEUE-BASED REDUCTION OF POWER CONSUMPTION AND LATENCY IN WIRELESS SENSOR NETWORKS
Authors:   Thakur College of Engineering and Technology, India, Ghosh Sanjeev , Unnikrishnan Srija ,   Fr. Conceicao Rodrigues College of Engineering, India
Published: October 2024

Longevity of wireless sensor networks (WSN) is dependent on the optimal utilization of power supply. To make optimal utilization of power and increase the operational life of the network, we present two techniques with the goal of decreasing the consumption of power in a sensor node by incorporating queuing theory. We analyze the performance of wireless sensor networks that implement a M/G/1 queue with two different queuing policies. The analysis is done with respect to two important aspects: power consumption and latency delay. The results of the analysis illustrate the fact that the power consumed at a wireless sensor node can be reduced significantly by optimal selection of thresholds. We also compare the two policies in terms of power consumption and latency and find that the Min (N, T) policy is better equipped to not only reduce the power consumption but also reduces the latency delay caused due to the introduction of the queuing thresholds. The results indicate that the schemes studied can be implemented in practical scenarios as they are effective in reducing power consumption and increasing the operational life of a WSN.
INVESTIGATION OF POTENTIAL MULTIPLE THREATS AND THEIR IMPACTS IN MANET
Authors:   Periyar University, India, G Jeeva , K Selvaraj ,   Arignar Anna Government Arts College, India
Published: October 2024

The dynamic nature of mobile ad-hoc network (MANET) provides consistent communication endurance. MANET is renowned for its selfconfigurable formation of interrelated network nodes. This decentralized property of MANET is vulnerable for various types of attacks which could impact the performance of the network and the protection of sensitive data transmitted through the network. The active node adaptation policy of MANET stipulates the possibility of multiple intruder instillations. Any intruder node can generate multiple attacks based on the potential and the rationale of the intrusion. The objective of this investigative work is to analyze the potential multiple threats and their possible consequences while using some prevailing security architectures along with relevant protocols. A common testbed is established with state-of-the-art network evaluation software OPNET in which random network environment with identical characteristics are used to evaluate the existing methods in terms of throughput, communication delays and security.