bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Profiling of Core Immune-Escape Genes Highlights LCK Has Potential to Reshape TME in Melanoma
Authors: Zhang Duoli , Zhang Zhuo , Xiang Shixin , Xiao Mintao , Zhang Yao , Duangmano Suwit , Wu Xu , Li Mingxing , Du Fukuan , Chen Yu , Yang Xiao , Zhao Yueshui , Zheng Yuan , Wen Qinglian , Li Jing , Shen Jing , Xiao Zhangang , Yang Zhongming
Published: September 2021

Background: The game between the immune system of the organism and the tumor is a dynamic course of events. Once the escape phase is reached, the tumor will overcome the limitations of the immune system and the tumor will progress. Objective: This study aimed to determine the potential tumor environment-based prognostic biomarkers related to immunotherapy in melanoma. Methods: 471 tumor samples and 398 normal samples were extracted from The Cancer Genome Atlas and The Genotype-Tissue Expression. Furthermore, a core set of immune-escape genes were collected from previous studies and a set of immune-related genes were obtained from IMMPORT database. Through overlapping these two sets of genes, a set of core immune-escape related genes were identified. In the next place, we conducted a systematic analysis of core immune-escape related genes through The Cancer Genome Atlas cohort and identified independent prognostic factors in melanoma. Through CIBERSORT, ssGSEA algorithm and TIMER database, we explored the potential of independent prognostic factors to reshape the tumor microenvironment.Results: Through Kaplan-Meier as well as univariate cox regression analysis of expression profiles and clinical information obtained from the TCGA cohort, we found that high LCK expression was associated with prolonged overall survival. In addition, the expression level of LCK was significantly correlated with the dysregulation of the infiltration level of immune cells in the tumor microenvironment. Conclusions: In this study, we determined LCK as a biomarker that is significantly associated with tumor environment and has significant prognostic significance. Meanwhile, immunotherapeutic approaches targeting LCK in tumor cells may provide a new perspective for the treatment of melanoma.
Miniaturizing transmon qubits using van der Waals materials
Authors: Antony Abhinandan , Gustafsson Martin , Ribeill Guilhem , Ware Matthew , Rajendran Anjaly , Govia Luke , Ohki Thomas , Taniguchi Takashi , Watanabe Kenji , Hone James , Fong Kin Chung
Published: September 2021

Quantum computers can potentially achieve an exponential speedup versus classical computers on certain computational tasks, recently demonstrated in systems of superconducting qubits. However, the capacitor electrodes that comprise these qubits must be large in order to avoid lossy dielectrics. This tactic hinders scaling by increasing parasitic coupling among circuit components, degrading individual qubit addressability, and limiting the spatial density of qubits. Here, we take advantage of the unique properties of van der Waals (vdW) materials to reduce the qubit area by $>1000$ times while preserving the required capacitance without increasing substantial loss. Our qubits combine conventional aluminum-based Josephson junctions with parallel-plate capacitors composed of crystalline layers of superconducting niobium diselenide and insulating hexagonal-boron nitride. We measure a vdW transmon $T_1$ relaxation time of 1.06 $\mu$s, which demonstrates a path to achieve high-qubit-density quantum processors with long coherence times, and the broad utility of layered heterostructures in low-loss, high-coherence quantum devices.
Development of an Optimal Relief Method for the Palatal Plate by Stress Analysis
Authors: Mukai Tomoko , Sato Yuji , Shimodaira Osamu , Furuya Junichi , Isobe Akio , Omori Tomoka
Published: September 2021

Background: A maxillary-palate-shaped device for simultaneous measurement of bite force and palatal mucosal subsidence at the time of pain onset in dentate persons has been developed. However, palatal mucosal stress analysis in a simulation based on three-dimensional finite element analysis is effective for objective and efficient evaluation of various types of denture-supporting mucosa. Recently plate dentures are not easily modified after the completion of these dentures , so it is essential to effectively assess the sites and magnitude of relief at the time of preparation. However, there is considerable variation in the magnitude of optimal relief and relief range, and there are no guidelines that present these clearly, leading the surgeon to decide subjectively. Thus, this study aimed to develop an optimal relief method to improve the stress bearing capacity of the palatal mucosa.Objectives: The objective of this study, the borderline was set in steps. The changes in stress distribution in the palatal mucosa due to the selective relief of stresses above the borderline were evaluated using a three-dimensional finite element simulation. The purpose of this study was to develop an optimal relief method to improve the bearing capacity of the palatal mucosa.Methods: The objective of this study, the borderline, was set in steps. A three-dimensional finite element model for the pseudopalatal plate was prepared and used to evaluate the changes in stress distribution in the palatal mucosa due to the selective relief of stresses above the borderline. The resulting data were used to develop the optimal relief method.Results: In the relief model with a borderline of 0.04 MPa or higher, the distribution volume at which high stress of 0.20 MPa or higher is generated was approximately about 800%％ of that with the no-relief model, and in the relief model with a borderline of 0.06 MPa or higher, the respective ratio was approximately about 280％%. On the other hand, the relief models with borderline of 0.14 MPa or higher were about 60%. In the mid-palatal relief model, the distribution volume at which stress of 0.20 MPa or higher was generated was 180% of that in the relief model.Conclusions: The supportive strength of plates can be increased by selectively applying optimal relief rather than standard relief, allowing for easier and more effective plate-denture treatment.
Preparations from Selected Cucurbit Vegetables as Antiplatelet Agents – An in Vitro Study
Authors: Rolnik Agata , Skalski Bartosz , Stochmal Anna , Olas Beata
Published: September 2021

Increased blood platelet activation plays an important role in cardiovascular diseases (CVDs). Recent experiments indicate that certain fruits and vegetables, including onion, garlic, and beetroot, have anti-platelet potential and therefore may reduce the likelihood of CVDs. While vegetables from the Cucuritaceae family are known to exerting beneficial antioxidant and anti-inflammatory effects, their effects on blood platelet activation are poorly understood. Therefore, the aim of the present study was to determine the effect on platelet adhesion of preparations from selected cucurbits: pumpkin (Cucirbita pepo; fruit without seeds), zucchini (Cucurbita pepo convar. giromontina; fruit with seeds), cucumber (Cucumis sativus; fruit with seeds), white pattypan squash (Cucurbita pepo var. patisoniana; fruit without seeds) and yellow pattypan squash (Cucurbita pepo var. patisoniana, fruit without seeds). It also evaluates the activity of these preparations on enzymatic lipid peroxidation in thrombin-activated washed blood platelets by TBARS assay. The study also determines the anti-platelet and anticoagulant properties of these five cucurbit preparations in whole blood by flow cytometry and with the total thrombus-formation analysis system (T-TAS) and evaluates the cytotoxicity of the tested preparations against platelets based on LDH activity. The results indicate that the yellow Cucurbita pepo var. patisoniana preparation demonstrated stronger anti-platelet properties than the other tested preparations, reducing the adhesion of thrombin-activated platelets to collagen/fibrinogen, and inhibiting arachidonic acid metabolism and GPIIb/IIIa expression on 10 µM ADP-activated platelets. None of the preparations was found to cause platelet lysis. Our findings provide new information on the anti-platelet activity of the tested cucurbit preparations and their potential for treating CVDs associated with platelet hyperactivity.
Sporamin Intervention Altered the Gut Microbiome and Tumor Tissue Transcriptome in Mice Intraperitoneally Xenografted With the Human Colorectal Carcinoma LoVo Cells
Authors: Yang Chun , Chen Bo-Wen , Zhang Kai-Wen , Chen Si-Jia , Zhang Xiao-Peng , Zhang Jing-Jie , Guo Ge , Li Peng-Gao
Published: September 2021

BackgroundAccumulating evidence indicates that sporamin, the main storage protein in the sweet potato (Ipomoea batatas), can suppress the development of colorectal cancer (CRC), but the changes in the gut microbiome after sporamin intervention and its relationships with the pathogenesis of CRC have not been investigated.MethodsTwelve male athymic BALB/c nude mice were randomly divided into four groups, CG1, CG2, TCG, and TTG. Mice in TCG and TTG were intraperitoneally transplanted with the LoVo cancer cells before the interventions started. CG2 and TTG were intragastrically infused with sporamin (0.5 g/kg BW/ day) for four weeks while CG1 and TCG were infused with the same volume of water during the experiment. Fecal samples were collected after the interventions and then examined for the changes in the microbiota using the 16S ribosomal RNA (rRNA) sequencing technology. The functional capabilities of the gut microbiota were predicted with the PICRUSt pipeline. Transcriptomic profiling of the tumor tissues was carried out for tumor-bearing mice with the RNA-sequencing (RNA-seq) technology and the resultant differentially expressed genes (DEGs) were then analyzed in terms of gene ontology (GO), protein-protein interaction (PPI), transcription factors (TF) prediction, and biological pathway annotations. ResultsSporamin significantly reduced the tumor burden of tumor-bearing mice and brought beneficial changes to the gut microbiome in both kinds of mice. It significantly increased the proportions of Barnesiella and Lactobacillus but reduced that of Bacteroides in tumor-bearing mice. The phenylalanine metabolism pathway, the glyoxylate, dicarboxylate metabolism, the bacterial secretion system, the glycan biosynthesis and metabolism, and the biosynthesis of stilbenoid, diarylheptanoid, and gingerol were favorably modulated by sporamin intervention. Sporamin mainly modulate the expression of the genes involved in the protein processing in the endoplasmic reticulum, the glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway, and the mineral absorption pathway. ConclusionSporamin could favorably alter the gut microbiome and its metabolome, improving the gut microenvironment and the viability of the gut microbiota and increasing the detoxification and bioactive substance production activities in the large intestine, by which the host’s metabolome may be altered and in turn exerts a suppressing effect on the protein synthesis and growth of tumor tissues.
Exploring nurse perceptions and experiences of resilience: a meta-synthesis study
Authors: Kim Eun Young , Chang Sung Ok
Published: September 2021

Aim To understand nurse resilience in depth by integrating the qualitative research results on nurses' resilience-related experiences.Methods : We applied the seven steps of the meta-ethnographic process by Noblit and Hare (1988). Six databases (PubMed, CINAHL, EMBASE, Web of Science, Cochrane, and Google Scholar) were used to search for studies published from January 2011 to August 2021.Results Sixteen qualitative studies were included. The four themes of “self-development though focusing on one’s inner self”, “building a positive strength for life”, “developing one’s own strategy for overcoming diversity” and “forward thinking to become a better nurse by planning for the future” illustrate that they want to promote their inner strength and develop themselves through self-examination.Conclusion : Through this study, we can understand more deeply about the resilience of nurses, and the results can provide basic data for the development of intervention study to improve the resilience of nurses.
Sociocultural and geographical disparities in immunization among different geographical regions of Maharashtra
Authors: Khadse Rushikesh , Thool Badal , Sarode Sunil
Published: September 2021

Background

In Maharashtra, child immunization is an essential factor in maternal and child health services and effective in reduced child morbidity and mortality. The study focuses on the prevalence of child immunization in different geographical regions of Maharashtra. It also depicts the immunization status (no immunization, partial immunization, and full immunization) according to various socio-demographic characteristics and determinants of full Immunization and partial Immunization among children of age 12–23 months in Maharashtra
Data source and Methodology:

The fourth round of the National Family Health Survey (NFHS-4) has been used for this study. The univariate analysis and simple chi-square test were conducted to test association. The Multinomial logistic regression model was conducted to determine the determinants of partial and full immunization.
Result

In the wealth category, the middle and richest are more likely to receive full immunization than the poorest people statically significant effect. In religion, Muslims less likely to receive full Immunization, and Buddhists more likely to use full immunization compare to Hindu people. In the different geographical regions of Maharashtra, North-Maharashtra, West-Maharashtra, Konkan is less likely to have full immunization correspond to the Vidarbha region. Mothers who have any media exposure are more likely to have full immunization compare to no media exposure.
Conclusions

To conclude, the study shows a need to adopt a multi-pronged strategy while formulating an action plan for immunization by keeping in mind that vaccination is a right of every child. An appropriate proportion of childhood immunization is required to develop “Herd Immunity” to protects other unimmunized children. The most “efficient” and “equitable” way should be chosen to deliver vaccination services to identify the population's risk group. Who has remained unimmunized? As immunization in the different geographical regions in Maharashtra remained very far from the target set by Mission Indradhushya. Hence, there is a need to focus more on responsible socio-demographic factors while implementing immunization services.
Biathletes Prefer a Closed-Looped Strategy to Maintain Their Balance During Shooting
Authors: Michalska Justyna , Zając Rafał , Szydło Krzysztof , Gerasimuk Dagmara , Słomka Kajetan J. , Juras Grzegorz
Published: September 2021

Background: Balance can also be a main factor contributing to success in many disciplines, and biathlon is a representative example. The center of foot pressure (COP) is commonly recorded when evaluating postural control. Because COP measurements are highly irregular and non-stationary, the non-linear deterministic methods are more appropriate for the analysis of COP displacement, such as entropy. The aim of our study was to investigate whether the longitudinal effects of biathlon training can elicit specific changes in postural control. Methods: 8 national-level biathletes, 15 non-athletes who prior to the experiment took part in 3 months of shooting training, and 15 non-athletes with no prior rifle shooting experience. The data was collected with the use of a force plate. Participants performed three balance tasks in quiet standing, the shooting position (internal focus), and aiming at the target (external focus). Results: Biathletes obtained significantly lower values of sample entropy compared to the other groups during shooting and aiming to the target trials (p<0.05).There were no significant differences in quiet standing trials between all three groups (p>0.05). External and internal focuses influenced the process of postural control among participants who had prior rifle shooting experience and the control group: they obtained significantly higher values of sample entropy during shooting and aiming to the target compared to the quiet standing trial (p<0.05). The biathletes obtained contrary results. There were no significant differences in the values of sample entropy between three consecutive trials in the ML plane; there was only one significant change in the AP plane. The biathletes obtained significantly lower values of sample entropy in aiming to the target position compared to the quiet standing trial. Conclusion: Specific balance training is associated with the ability to deal with a more challenging nonspecific task. The biathletes seemed to employ a different motor control strategy than the beginners and control group. They create repeating patterns (more regular signal for COP), which is a vigilant closed-loped strategy to keep one’s balance during the shooting and aiming to the target positions.
Efficient Welding Defect Detectionand Classification of Phased Array C-Scan Images Using Modified Fast Fuzzy C Means Andradial Bias Function Neural Network
Authors: C Jayasudha J , S Lalithakumari
Published: September 2021

In the recent past, phased array technology is one of the most important methodologies used for inspection of welding. The welding defect identification is a difficult task due to noise content and uneven illumination and contrast on phased array 2D image. Artificial Neural Network (ANN) is a recent Machine Learning (ML) technology that has been achieved a lot of attention over the recent years. The saliency feature extraction for representing image has become complex due to quality of 2D image. The proper image restoration and enhancement techniques should be applied in order to improve the quality of 2D phased array image. The 2D-Adaptive Anisotropic Diffusion Filter (2D AADF) is applied to eliminate noises such as impulse noise and speckle noise. The Adaptive Mean Adjustment-Contrast Limited Adaptive Histogram Equalization (AMA-CLAHE) is the enhancement technique that is applied to improve contrast and brightness of the phased array 2D image. The welding defect region can be exactly segmented using saliency mapping to contour boundaries of defects in welding. In this paper, a novel methodology for welding defect detection is applied based on Modified Fast Fuzzy C Means (MFFCM) clustering technique by integrating Probability Mass Function (PMF) threshold technique for higher range of efficient and accurate segmentation. The Gray Level Co-Occurrence Matrix (GLCM) and 2D Band-let Transform (2D BT) are applied to extract features on segmented image. TheRadial Bias Function Neural Network (RBFNN) classifier is one of the ANN classifier for classifying welding defects. Most of image classification techniques utilize RBFNN as they will provide great range of accuracy and precision while compared to existing techniques. The localized generation error model is implemented in RBFNN in order to minimize Mean Square Error (MSE). The efficiency and accuracy of the proposed methodology has been evaluated with the help of experimental results in terms of graphical representation and numerical analysis.
The Effectiveness of Mobile-Learning in Teaching Corrective Exercises to Scoliosis Patients: A Quasi-Experimental Study
Authors: heshmati Arefeh , Hazrati Hakimeh , Salahzade Zahra , hachesu Peyman Rezaei hachesu Rezaei , ekrami Nushin khalili , Soltani Taha Samad Soltani Samad
Published: September 2021

Background
Mobile-learning (M-learning) has recently provided new opportunities and facilitated patient education due to its attractiveness and ease of access. As a result, the present study aimed to design an application (app) and evaluate the effectiveness of M-learning in teaching CEx to patients suffering from scoliosis.
Methods
This quasi-experimental study was fulfilled in two phases, namely, app design and educational intervention among scoliosis patients, and then reflections on the effectiveness of the app and educational intervention implementation concerned. Within the implementation step, the scoliosis patients referred to the rehabilitation center affiliated with Tabriz University of Medical Sciences, Tabriz, Iran, were divided into case and control groups upon imaging and grading their spine curvature. The effectiveness of the educational intervention was also assessed through the rate of recovery in spine curvature and users’ opinions and satisfaction with the app usability via the User Experience Questionnaire (UEQ).
Results
In this sense, the accuracy index was equal to 100% based on physiotherapists’ approval. The level of satisfaction with the educational intervention in the case group with a mean value of 97% was also higher than that in the controls (88%). Moreover, the values ​​of the Cob angle change in the case group were significantly higher than that in the controls. Based on the analysis of the UEQ outcomes, the highest and the lowest levels of satisfaction among the users were associated with the “perspicuity” and “stimulation” dimensions of the app, respectively.
Conclusion
Given that the new models of care are today mostly focused on the role of patients, moving toward patient self-management, the app designed here could be utilized as a model for developing broader similar systems and programs for treatment management, patient monitoring, emergency response, personalized health monitoring, and widespread access to health care information.
The Association of Serum Levels of stromolysin-1 and connexin-37 with the severity of coronary artery disease
Authors: Naebian Melika , Aslanabadi Naser , Nourazarian Alireza , Rahbarghazi Reza , shademan behrouz , Vatankhah Amir Mansour , khaki-khatibi Fatemeh
Published: September 2021

Background Coronary Artery Disease (CAD) is a common form of heart disease that is considered a serious health problem in society. Atherosclerosis is widely recognized as a chronic inflammatory disease of the vessels and can lead to CAD and myocardial infarction. The aim of the present study was to investigate serum levels of connexin-37 and stromelysin-1 as significant biomarkers of CAD and their correlation with the extent of CAD. Methods and results Sixty CAD patients with one-vessel (1VD), two-vessel (2VD), and three-vessel (3VD) disease were enrolled in this study. For comparison with the results, 20 healthy control subjects were also included in this study. Serum concentrations of connexin-37 and stromelysin-1 were determined using commercial ELISA kits. Serum connexin-37 concentrations were not significantly different between the patient and control groups (p < 0.05). The analysis showed a statistically significant difference between subjects with one-vessel disease, subjects with two-vessel disease, and subjects with three-vessel disease. Serum Stromelysin-1 concentration was significantly higher in the patients than in the control group (p < 0.05). Conclusions The results of our study indicate that serum levels of stromelysin-1, but not connexin-37, may contribute to the prediction of the occurrence and progression of CAD.
A Highly Pathogenic Marek’s Disease Virus Isolated From a Immunized to Bivalent Vaccines Chicken Farm in China
Authors: Li Huimin , Ge Zengxu , Luo Qiong , Fu Qiang , Chen Ruiai
Published: September 2021

Marek’s disease virus (MDV) is an important oncogenic poultry pathogen that can generally be controlled by vaccination. However, MDV still occasionally occurs on vaccinated farms owing to possible genetic variation among MDV strains as well as management-related issues. In this study, a novel MDV strain (designated LZ1309) was isolated from a poultry flock that had been previously vaccinated using the HVT plus CVI988 vaccine strains. Animal experiments showed that LZ1309 infection led higher morbidity (100%) and mortality (90%). Moreover, existing vaccines only provided partial protection against LZ1309, which protection indexes of HVT, CVI988, and HVT plus CVI988 were 68.4%, 85%, and 90%, respectively. In conclusion, we have shown that the more virulent of Marek’s disease virus existed in vaccinated with HVT plus CVI988 in poultry farms in China. And the emergence of LZ1309 poses a new potential threat to poultry farms. In future studies, the development of new treatment strategies should be of high priority.
Artificial “Nano-Targeted Cells” for Bimodal Imaging-Guided Tumor Cocktail Therapy
Authors: Chen Qiaoqi , Zhang Liang , Li Lin , Tan Mixiao , Liu Weiwei , Liu Shuling , Xie Zhuoyan , Zhang Wei , Wang Zhigang , Cao Yang , Shang Tingting , Ran Haitao
Published: September 2021

Background: Single therapeutic modality always has its limitations in combating metastatic lesions with complicacy. Although the emerging immunotherapy exhibits preliminary success, solid tumors are usually immunosuppressive, leading to ineffective antitumor immune responses and immunotherapeutic resistance. Rational combination of several therapeutic modalities may potentially become a new therapeutic strategy to effectively combat cancer.Results: Poly lactic-co-glycolic acid (PLGA) nanospheres were constructed with photothermal transduction agents (PTAs)- Prussian blue (PB) encapsulated in the core and chemotherapeutic docetaxel (DTX)/ immune adjuvant- imiquimod (R837) loaded in the shell. Tumor cell membranes were further coated outside PLGA nanospheres (designated as “M@P-PDR”), which acted as “Nano-targeted cells” to actively accumulate in tumor sites, which was guided/monitored by photoacoustic (PA)/ magnetic resonance (MR) imaging. Upon laser irradiation, photothermal effects were triggered. Combined with DTX, PTT induced in situ tumor eradication. Assisted by immune adjuvant R837, the maturation of DCs were promoted. Besides, DTX polarized M2-phenotype tumor-associated macrophages (TAMs) to M1-phenotype, relieving immunosuppressive TME. Integrating the above processes, the infiltration of cytotoxic T lymphocytes (CTLs) increased. The primary tumors and metastasis were significantly inhibited when treated with “Nano-targeted cells” based cocktail therapy.Conclusion: “Nano-targeted cells” based therapeutic cocktail therapy is a promising approach to promote tumor regression and counter metastasis/ recurrence.
Designing of a novel multisubunit vaccine against Nipah virus structural proteins: A reverse vaccinology approach
Authors: Adam khalid Mohamed
Published: September 2021

Background

The significant public health risk posed by NiV zoonosis and the lack of effective countermeasures against the intermittent outbreaks of the disease in the South and Southeast Asia region have entailed an imperative search for a protective vaccine to prevent or mitigate its epidemic potentiality. This is an endeavor to design an effective, safe multisubunit vaccine using an in silico reverse vaccinology approach.
Methods

The epitopes used for the construction of the candidate vaccine were meticulously predicted from five viral structural proteins (G, F, M, N, P) using several immunoinformatics tools to assess different epitope characteristics, namely, VaxiJen server for antigenicity, IEDB immunogenicity tool for immunogenicity, AlgPred server for allergenicity, ToxinPred for toxigenicity, IFNepitope server for interferon-gamma induction, Protparam server for physicochemical properties, GROMACS for simulation and simulation dynamics analysis, and finally, SnapGene tool for molecular cloning.
Results

The proposed vaccine molecule consisted of 501 amino acids, encompassing 7 B cell epitopes, 14 CTL epitopes, and 4 HTL epitopes. The physiochemical parameters of the vaccine construct showed a molecular weight of 54.6 kDa, an acidic stable molecule with an instability index of 38.3, aliphatic index of 62.89, and grand average of hydropathicity of -0.476. Moreover, the docking results and simulation dynamics of the vaccine molecule and TLR-3 showed global energy of 1.58 Kcal/mol, atomic contact energy of 2.98 Kcal/mol, and RMSD of 0.65 nm. The radius gyration showed a relatively steady value throughout the simulation period. a suggestive result of a stable compact structure and a promisingly effective vaccine construct.
Conclusion

In summary, the overall results of the multi-subunit vaccine molecule are suggestive of a promisingly effective vaccine against NiV infection in humans with a relatively stable compact structure, however, further experimental validation and assessment of pathogenic priming and autoimmunity induction are recommended.
Negative Pressure Wound Therapy versus Gauze Dressings in Managing Open Fracture Wound of Lower Limbs: An Update Meta-Analysis of Randomized Controlled Trials
Authors: Qian Hu , Lei Ting , Hu Yihe
Published: September 2021

IntroductionWhether the negative pressure wound therapy (NPWT) is superior to standard gauze dressings in managing open fracture wounds of lower limbs still remains a controversy. Herein, we updated a meta-analysis only including RCTs to comprehensively compare the clinical efficacy of the two dressings.Materials and methodsWe searched various databases including PubMed, Web of Science, Medline, Clinicaltrial.gov and Cochrane Library to screen eligible RCTs. Data extraction was performed by two reviewers independently. The data analysis was carried out using the Review Manager 5.3 software.ResultsThere were 10 RCTs, along with 2780 patients, eligible for meta-analysis. We found patients in the NPWT group showed lower overall infection rate (MD = 0.70, 95% CI: 0.54 − 0.90, P = 0.005), acute wound infection rate (MD = 0.35, 95% CI: 0.16 − 0.77, P = 0.009) and shorter hospital stay (MD = 24.00, 95% CI: 6.82–84.46, P < 0.00001) as compared with the control group. And the NPWT group showed higher proportion of patients with wound coverage than the control group. While no significant difference was found between the two groups in terms of function score and other complications including deep infection rate, amputation and bone nonunion.ConclusionBased on the pooled results, we suggested that NPWT could be an alternative choice over traditional gauze dressings in managing the wound of open fracture of lower limbs.
Avaliação dos Estilos Cognitivos Quanto às Fases do Processo Decisório: Análise com Acadêmicos de Diferentes Áreas do Conhecimento
Authors: Karpinski Atais Catarina , Cogo Dieli Cristina , Antonelli Ricardo Adriano , Meurer Alison Martins
Published: September 2021

A Psicologia Cognitiva tem sido estudada por vários autores com elaboração de teorias a fim de explicar o desenvolvimento do intelecto humano. Da mesma forma, o estudo do Processo Decisório tem obtido, gradativamente, destaque nas pesquisas que envolvem indivíduos, grupos e organizações, resultante da exigência de maior eficácia por parte dos tomadores de decisão. A presente pesquisa tem como objetivo identificar a percepção dos acadêmicos de diferentes Estilos Cognitivos quanto às fases do Processo Decisório. Os dados foram coletados por meio de questionário, que primeiramente buscou-se identificar o grau de importância e o tempo gasto no processo de tomada de decisão, além de identificar o Estilo Cognitivo de cada indivíduo, utilizando-se para isso do instrumento Cognitive Style Index (CSI) de Allinson e Hayes (1996). A amostra foi composta por 100 acadêmicos do curso de Ciências Contábeis e 86 acadêmicos do curso de Letras. A partir da análise dos resultados, pode-se identificar que 40,3% dos acadêmicos possuem o Estilo Analítico e apenas 2,7% possuem o Estilo Intuitivo. Também verificou-se que os acadêmicos de Ciências Contábeis atribuem maior importância nas fases do Processo Decisório, enquanto que os acadêmicos de Letras julgam gastar mais tempo nas fases do Processo Decisório. Adicionalmente, foi realizado testes não paramétricos referente as questões do Processo Decisório, em que das seis correlações possíveis, foi obtido significância estatística em cinco delas, sendo elas: gênero, idade, ano do curso, outra graduação e curso. Já ao relacionar o Estilo Cognitivo obteve-se significância estatística apenas em relação ao curso. Os resultados indicam que indivíduos de diferentes estilos atribuem importância de modo diferente quanto ao processo de tomada de decisão.
DISCLOSURE DOS ELEMENTOS PATRIMONIAIS DO SETOR PÚBLICO NA REGIÃO SUDESTE
Authors: Delamora Andrea , Gonçalves Morgana , Gama Janyluce Rezende , Caliman Douglas Roriz
Published: September 2021

A evidenciação dos elementos patrimoniais, sejam eles públicos ou privados, tem assumido um espaço de destaque no setor contábil, visando melhorar a transparência das informações de caráter financeiro, econômico, orçamentário e operacional, possibilitando a realização de tomadas de decisões que promovam um progresso patrimonial da entidade. Essa melhora na transparência vem ganhando notoriedade no setor público brasileiro, por meio do processo de convergência, à luz das orientações provenientes das Normas Internacionais de Contabilidade Aplicadas ao Setor Público (IPSAS). Este artigo objetiva verificar a evolução do disclosure dos elementos patrimoniais do setor público na região sudeste brasileira. Para isso comparou-se os dados apresentados nas notas explicativas das demonstrações contábeis do setor público dos estados da região sudeste no período de 2014 a 2016, utilizando-se uma pesquisa qualitativa e documental. Os resultados indicam que os governos, no âmbito estadual, iniciaram a implantação das práticas contábeis patrimoniais obrigatórias e avançam gradualmente na evidenciação dos itens pesquisados, com melhores índices em 2016. O estado do Rio de Janeiro apresenta o melhor disclosure na região sudeste, demonstrando no total maior média de dados. São Paulo aparece em segundo, em terceiro está o Espírito Santo e em último com menor disclosure na média de dados está Minas Gerais.
Você foi Adicionado! A Participação em Grupos e a Intenção de Uso do WhatsApp a partir dos Fatores da Personalidade
Authors: Radons Daiane Lindner , Visentini Monize Sâmara , Löbler Mauri Leodir
Published: September 2021

Os traços de personalidade determinam os comportamentos de um indivíduo em diferentes aspectos da vida, incluindo sua intenção e uso de tecnologias. Assim, este artigo teve como objetivo verificar as relações entre os fatores da personalidade do indivíduo e sua intenção de uso do WhatsApp e a participação em grupos neste aplicativo. Realizou-se uma pesquisa survey, com 401 usuários do aplicativo. Foram utilizados três modelos teóricos, o Inventário dos Cinco Grandes Fatores da Personalidade (CGF) que foi validado no Brasil por Andrade (2008); o constructo Intenção Comportamental de Uso, da Teoria Unificada de Aceitação e Uso da Tecnologia (Unified Theory of Acceptance) – UTAUT, desenvolvido por Venkatesh et al. (2003); e o nível de participação em grupos, baseado em Bronstein et al. (2016). A análise dos resultados demonstrou que, das onze hipóteses propostas, cinco foram suportadas, indicando que pessoas extrovertidas e com altos níveis de Neuroticismo possuem intenção de usar o WhatsApp. Também foi constatado que os indivíduos que apresentam altos escores na dimensão Abertura e que são extrovertidos tendem a participar de grupos nessa rede social. Por fim, verificou-se que a intenção de uso do WhatsApp afeta positivamente a participação em grupos no aplicativo. Comprovou-se, assim, que as pessoas possuem motivações e interesses em relação às redes sociais virtuais de acordo com seus traços de personalidade, o que implica em considerar diferentes estratégias de comunicação e plataformas digitais para tornar o canal online uma ferramenta eficaz de comunicação e interação.
O Contador e suas Controversas Relações com o Capitalismo e a Sociedade
Authors: Nepomuceno Valério , Rech Ilírio José
Published: September 2021

O propósito deste ensaio teórico é analisar as relações controversas do contador com o capitalista e a sociedade. A análise foi realizada sob quatro aspectos distintos e complementares, tendo por referência a premissa de que a Contabilidade serviu como instrumento para suportar o capitalismo. O primeiro aspecto refere-se às relações do contador com o conceito de verdade, que é uma representação fiel da realidade, enquanto o outro conceito é, para alguns pesquisadores, uma objetividade paradigmática com possibilidades críticas e construtivas; o segundo visa verificar as influências dos economistas no desenvolvimento da Contabilidade do século XX cuja influência clássica e neoclássica tem buscado defini-la como um objeto prático para a economia; terceiro, a inexistência do contador intelectual, por força da instrumentalidade da profissão, tem permitido o recrudescimento da classe em favor do status quo; e quarto, em que medida a educação superior em Contabilidade tem determinado o fortalecimento da instrumentalidade contábil em favor do capitalismo. O método utilizado é o ensaio teórico. A conclusão é que o contador, em larga medida, age sob posições controversas em face das aspirações da sociedade e das expectativas do capitalista. O contador usa a contabilidade como um instrumento de emancipação por meio de uma linguagem representativa dos interesses privados, sem levar em conta o interesse público. Exemplo dessa instrumentalidade são as International Financial Reporting Standards (IFRS) e o domínio da informação contábil pelas agremiações contábeis profissionais.
Accounting as Practice
Authors: Major Maria , Clegg Stewart
Published: September 2021

Neste paper procuramos debater alguns dos problemas que afetam a pesquisa positivista em contabilidade, e como a adoção da teoria organizacional baseada em métodos qualitativos pode frutiferamente contribuir para o avanço da pesquisa nesta área. Para este fim nos baseamos em pesquisas que conduzimos em hospitais públicos Portugueses para discutir como a incorporação de questões de poder, empreendedorismo institucional, hibridização, lógicas institucionais e trabalho institucional em trabalhos de contabilidade incentivam explicações mais profundas da prática contábil.
Nenhum Saber a Menos!
Authors: Da Silva Sandra Maria Cerqueira
Published: September 2021

Antes de discorrer sobre o pretendido, é importante situar vocês leitores sobre algo do percurso de quem vos fala; de minhas andanças como uma mulher negra por lugares sempre apontados como um não lugar para mulheres, e ainda menos para negras (os). Para tanto, esboço um passeio rápido pelos momentos mais recentes de minha traje / história. Assim, optei por socializar minha experiência no doutorado.
The Cosmological Bootstrap: Spinning correlators from symmetries and factorization
Authors: Baumann Daniel , Duaso Pueyo Carlos , Joyce Austin , Lee Hayden , L. Pimentel Guilherme
Published: September 2021

We extend the cosmological bootstrap to correlators involving massless spinning particles, focusing on spin-1 and spin-2. In de Sitter space, these correlators are constrained both by symmetries and by locality.
In particular, the de Sitter isometries become conformal symmetries on the future boundary of the spacetime, which are reflected in a set of Ward identities that the boundary correlators must satisfy. We solve these Ward identities by acting with weight-shifting operators on scalar seed solutions. Using this weight-shifting approach, we derive three- and four-point correlators of massless spin-1 and spin-2 fields with conformally coupled scalars.
Four-point functions arising from tree-level exchange are singular in particular kinematic configurations, and the coefficients of these singularities satisfy certain factorization properties. We show that in many cases these factorization limits fix the structure of the correlators uniquely, without having to solve the conformal Ward identities.
The additional constraint of locality for massless spinning particles manifests itself as current conservation on the boundary. We find that the four-point functions only satisfy current conservation if the s, t, and u-channels are related to each other, leading to nontrivial constraints on the couplings between the conserved currents and other operators in the theory. For spin-1 currents this implies charge conservation, while for spin-2 currents we recover the equivalence principle from a purely boundary perspective.
For multiple spin-1 fields, we recover the structure of Yang--Mills theory.
Finally, we apply our methods to slow-roll inflation and derive a few phenomenologically relevant scalar-tensor three-point functions.
Navigator function for the conformal bootstrap
Authors: Reehorst Marten , Rychkov Slava , Simmons-Duffin David , Sirois Benoit , Su Ning , van Rees Balt
Published: September 2021

Current numerical conformal bootstrap techniques carve out islands in theory space by repeatedly checking whether points are allowed or excluded. We propose a new method for searching theory space that replaces the binary information "allowed"/"excluded" with a continuous "navigator" function that is negative in the allowed region and positive in the excluded region. Such a navigator function allows one to efficiently explore high-dimensional parameter spaces and smoothly sail towards any islands they may contain. The specific functions we introduce have several attractive features: they are well-defined in large regions of parameter space, can be computed with standard methods, and evaluation of their gradient is immediate due to an SDP gradient formula that we provide. The latter property allows for the use of efficient quasi-Newton optimization methods, which we illustrate by navigating towards the 3d Ising island.
Análisis numérico del flujo sobre-expandido en la tobera cónica experimental ULA-1B fuera de diseño
Authors: Tolentino Masgo San Luis Baudilio , González Campos Omar
Published: September 2021

En las toberas supersónicas, ocurren diferentes patrones de flujo y su comportamiento está influenciado por las geometrías de las superficies internas de las paredes. En el presente trabajo se simula en 2D el campo de flujo sobrexpandido en la tobera cónica experimental ULA-1B fuera de diseño, para dos casos de longitudes de garganta: Lg=15mm y Lg=1mm; con el fin de analizar el campo de número de Mach, presión y temperatura. Se empleó el código ANSYS-Fluent y se aplicó el modelo RANS; las ecuaciones gobernantes: conservación de la masa, cantidad de movimiento, energía, y estado; así como el modelo de turbulencia de Menter y la ecuación de Sutherland para la viscosidad en función de la temperatura. En la sección de la garganta de mayor longitud, los resultados mostraron choques oblicuos, fluctuaciones de velocidad, presión y temperatura; para la garganta de menor longitud no hubo fluctuaciones; para ambos casos, el flujo en la divergente presentó picos de velocidad en el rango de 2,5-3  Mach. Se concluye que, para la menor longitud de garganta el flujo se acelera sin perturbaciones en dicha sección; en la divergente se presenta un chorro supersónico y una separación de flujo
The in situ remediation of aquaculture water and sediment by commercial probiotics immobilized on different carriers
Authors: Yi Mengmeng , Wang Chun , Wang He , Zhu Xi , Liu Zhigang , Gao Fengying , Ke Xiaoli , Cao Jianmeng , Wang Miao , Liu Ying , Lu Maixin
Published: September 2021

In the present study, we investigated the effect of probiotics immobilized by oyster shells (Os), vesuvianite (Ve) and walnut shells (Ws) on the remediation of aquaculture water and sediment by analyzing the variation of ammonia-nitrogen (NH4–N), nitrate-nitrogen (NO3–N), nitrite-nitrogen (NO2–N), total nitrogen (TN), total phosphorus (TP) and chemical oxygen demand (CODCr), as well as the microbiota of the water and sediment. The positive or negative effects of the treatment groups on the water quality parameters were both observed. Compared with their effects on water quality parameters, the treatment groups had better effects on sediment parameters. Group Ve had the best remediation effect of NH4–N and NO3–N in the sediment (decreased by 5.22 and 1.66 times, respectively). Group Os showed a lower relative concentration of TN and CODCr (decreased by 3.77 and 0.95 times, respectively). The high-throughput sequencing results revealed that the immobilized probiotics increased the relative abundances of functional bacteria in the treatment groups at the phylum and genus level. The above results showed that probiotics immobilized by oyster shells, vesuvianite and walnut shells positively affected the aquaculture environment's remediation, especially the sediment.
Alinhamento de Pesquisas Científicas com os ODS da Agenda 2030: um Recorte Territorial
Authors: Gaertner Elaine Wantroba , Kuster de Oliveira Rafael , Limont Marcelo , Fernandes Valdir
Published: September 2021

A comunidade científica teve papel central na ascensão da agenda global de desenvolvimento pautada em objetivos (os Objetivos do Desenvolvimento Sustentável - ODS), metas e indicadores. Por seu turno, a Agenda 2030 incitou a comunidade acadêmica a avaliar a produção científica em relação aos temas da própria agenda. Neste contexto, abordagens de mapeamento de ODS se proliferaram. No entanto, existem raras iniciativas para investigar seus resultados. O objetivo deste estudo é explorar a aplicação de uma destas abordagens sob um recorte territorial, tomando-se como exemplo a Região Metropolitana de Curitiba (Região Sul do Brasil). Adotou-se a abordagem de mapeamento de ODS de Korfgen et al. (2018). Consultou-se artigos e revisões indexados na Scopus, Web of Science e Scielo no período 2010-2019. Aplicou-se o Index de Atividade Relativa (RAI) e análise visual de redes. As seguintes redes de coocorrência foram geradas com o aporte do software VOSviewer: coautoria institucional, interação entre os ODS, mapa de tópicos e relações interdisciplinares. Os campos científicos de um documento foram definidos como os principais campos dos seus respectivos autores. Como um dos resultados da pesquisa, a maioria dos documentos foi mapeada a pelo menos um ODS. Este padrão se repetiu quando replicamos a abordagem para outras regiões. Saúde e Bem-estar obteve a maior fração das publicações sobre a Região Metropolitana de Curitiba. O RAI aponta que frações similares são comuns em pesquisas sobre outras cidades brasileiras. Por outro lado, o RAI indica que a Região Metropolitana de Curitiba está abaixo do padrão brasileiro e internacional para os ODS: Erradicação da Pobreza e Fome Zero, embora ambos sejam de extrema relevância para o território. As análises de rede apresentam evidências empíricas de que os tópicos dos ODS estão intimamente entrelaçados, corroborando a proposição de que focar nas interações e sinergias entre os ODS seria uma abordagem mais eficiente para implementar a Agenda 2030 do que perseguir os ODS individualmente. Focar em tais interações e sinergias exigirão esforços de construções inter e transdisciplinares.
Sprawozdanie z III Ogólnopolskiego Forum Młodych Kryminologów Badania kryminologiczne a praktyka – perspektywa krajowa i międzynarodowa, Białystok 23-25 września 2020 r.
Authors: Płońska Emilia
Published: September 2021

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DZIAŁALNOŚć GOSPODARCZA W ROZUMIENIU USTAWY O PODATKU OD TOWARÓW I USŁUG ORAZ USTAWY O PODATKU DOCHODOWYM OD OSÓB FIZYCZNYCH
Authors: Gajewski Piotr
Published: September 2021

Celem autora było przedstawienie zrealizowania zasady autonomii prawa podatkowego w stosunku do definicji działalności gospodarczej, która stanowi prawne odzwierciedlenie zjawiska ekonomicznego. Autor przedstawił definicję działalności gospodarczej określoną w przepisach ustaw podatkowych i porównał pod względem prawnym wyżej wymienione definicje z definicją określoną na podstawie ustawy z 6 marca 2018 r. – Prawo przedsiębiorców (Dz. U. z 2019 r. poz. 1292 ze zm.). Autor analizował powiązania pomiędzy definicjami działalności gospodarczej a realiami obrotu gospodarczego i przedstawił błędy legislacyjne zawarte w definicjach działalności gospodarczej zawarte w ustawach podatkowych. Dokonano analizy w zakresie możliwości zniwelowania obowiązków podatkowych u osób prowadzących działalność nieewidencjonowaną w rozumieniu ustawy – Prawo przedsiębiorców. W niniejszym opracowaniu w odniesieniu do badania aktów prawnych zostały wykorzystane dwie metody: dogmatycznoprawna oraz historycznoprawna. Badania zostały przeprowadzone przy użyciu krytycznej analizy orzecznictwa sądów administracyjnych oraz Trybunału Sprawiedliwości Unii Europejskiej.