bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of lipid profile and uterine artery doppler in predicting risk of preeclampsia in early second trimester
Authors: Chopra Sheena , Pahwa Sangeeta
Published: April 2020

Background: Preeclampsia is associated with adverse pregnancy outcome and is a major cause of the fetomaternal morbidity and mortality. This study aimed at finding the role of lipid profile and uterine artery Doppler as a reliable predictor of risk of preeclampsia in early second trimester.Methods: This study is conducted in the obstetrics and gynecology department of a tertiary care teaching hospital, Amritsar. Lipid profile and Uterine artery doppler is estimated in 100 antenatal women from 14-20 weeks of period of gestation who met the inclusion criteria and are followed up till delivery or till preeclampsia sets in.Results: Out of 100 subjects 74 remained normotensive (Group A) and 26 developed preeclampsia (Group B). The mean serum level of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL) and very low-density lipoprotein cholesterol (VLDL) was significantly higher in Group B as compared to group A women. The Preeclamptic women showed significant fall in high density lipoprotein cholesterol (HDL) level as compared to normal pregnant women. The mean S/D ratio, PI and RI values of uterine artery Doppler were higher for group B and were statistically significant.Conclusions: The combined predictive value of lipid profile and uterine artery Doppler for estimating risk of preeclampsia was more reliable than of any of the test individually.
Estudio descriptivo de la anatomía radiográfica ósea del cuy (Cavia porcellus) no mejorado y el cuy mejorado raza Perú
Authors: Guillén Karina , Grandez Ricardo , Chauca Lilia , Chauca Denise , Valencia Roberto
Published: April 2020

Objetivo: el presente estudio se realizó con la finalidad de conocer las características del esqueleto del cuy raza Perú mediante el empleo de radiografías y determinar los cambios experimentados por el mejoramiento genético, comparándolos con el cuy no mejorado. Metodología: se evaluaron 31 animales machos de 16 semanas de edad (16 animales raza Perú y 15 animales no mejorados), ambos grupos compartieron las mismas condiciones de ambiente, tipo de ración y manejo. Los animales fueron manipulados bajo sedación, las vistas radiográficas fueron: ventro dorsal y latero lateral. Se evaluó el esqueleto de cabeza, húmero, radio, ulna, tercera vértebra cervical, décimo segunda vértebra torácica, cuarta vértebra lumbar, pelvis, fémur y tibia; así como el número de vértebras cervicales, torácicas y lumbares. Resultados: fueron sobresalientes a favor de la raza Perú, que tuvo un crecimiento mayor en: ancho de vértebra cervical 56.57%, ancho del húmero 31.44%, ancho caudal de la pelvis, 51.32%, y ancho de la tibia 32.28%. También se evaluó el incremento de peso en los animales y se realizó la respectiva comparación siendo el resultado 171.40% mayor para la raza Perú. Conclusiones: el estudio demuestra que el mejoramiento por selección realizado en los cuyes raza Perú ha producido un cambio notorio en su peso y longitud respecto a los no mejorados, el crecimiento ha sido proporcional determinando una forma similar a un paralelepípedo rectangular característico en un animal productor de carne, y las vértebras cervicales desarrollaron de manera proporcional al crecimiento de la cabeza originando el acortamiento del eje longitudinal de la raza.
Issues related to personal and social self-development of academic staff members of higher education institutions in today's Russia
Authors: Vekovtceva Tatiana A. , Mishina Vera D. , Cherednyakova Anna B.
Published: April 2020

The issues addressed in the article are of particular relevance due to the growing role of teachers of higher education institutions in the modern society. The article is dedicated to the current issues of self-development of teachers and is aimed to identify the main reasons for their poor social and personal self-development. The most important research method used by the authors was the pedagogic experiment, including such particular empirical methods as monitoring, tests, surveys, questionnaires, interviews, self-assessment and psychological diagnostics. As a result of the study, it was found out that teachers' leisure time is not properly organised, therefore they have no opportunities for rehabilitation and recreation in their free time, which considerably reduces effectiveness of their personal self-development. The article describes a set of measures aimed to enhance the effectiveness of teachers' self-development through the organization of cultural and creative associations in higher education institutions, including four stages and six spheres of activity that can be implemented in such cultural and creative associations. Materials of this article may be useful for the management of higher education institutions and department heads, advanced training centres for higher education professionals and for all academic staff members.
Proteomic analysis of synovial tissue in rheumatoid arthritis, OLFM4 promotes fibroblast like synoviocytes proliferation in RA
Authors: Ren Xiaoyu , Xu Ke , Xu Jing , Geng Manman , Lu Chao , Kong Linbo , Cai Yongsong , Hou Weikun , Lu Yufeng , Aihaiti Yirixiati , Wang Ru , Xu Peng
Published: April 2020

Background To understand the roles of synovial tissue in rheumatoid arthritis (RA), we comprehensively investigated the protein profiles of synovial tissues in patients with RA and osteoarthritis (OA). Methods Protein were isolated from synovial tissues of 46 patients (22 with RA, 24with OA). Proteins were digested and labeled with TMT kit. All the peptide were send to LC-MS/MS analysis, and processed with Mascot and Proteome Discovery (version 1.4) search engines. All the protein data were analysis with Gene ontology (GO) and KEGG on line database. Four up-regulated protein were examined with western blotting and IHC. The RNAi were used for revealing the OLFM4 function in FLS. Results In total, over 500 proteins were identified as the different expression protein compared RA and OA synovia tissues, including 239 proteins were up-regulated in RA, and 271 proteins were up-regulated in OA. GO and KEGG analysis of the different expressed protein mostly identified as developmental processes and protein processing in ER. RT-qPCR, western blotting and IHC confirmed that there was a strong over expressed OLFM4 in RA synovia tissues. OLFM4 could be up-regulated under inflammatory stimulation, and participate in fibroblast like synoviocytes proliferation. Conclusion patients with RA possessed considerably different protein profiles of synovial tissues from with OA. The unique protein profiles of RA synovial tissues, such as the OLFM4 and MZB1 had been up-regulated compared to the OA, may reflect the pathophysiology of RA.
Design of a GFP reporter for splicing analysis in mammalian cells
Authors: Menezes Arthur T. , Nagasse Helder Y. , Coltri Patricia Pereira
Published: April 2020

Objective: The great majority of eukaryotic genes are formed by exons and introns. Pre-RNA transcripts are extensively co-transcriptionally processed, with the addition of a cap group at the 5′ end, intron removal and exon ligation (splicing) followed by addition of a poly-A tail at 3′ end. Splicing is performed by specialized macromolecular machinery named spliceosome, composed of five small ribonucleoprotein particles (snRNPs) and several proteins. The activity of this complex is highly accurate due to coordinated activity of its components. Altered splicing have already been related to the development of several diseases as amyotrophic lateral sclerosis and different types of cancer. Detailed understanding of splicing regulation in eukaryotic cells can be achieved using splicing reporter systems. Results: We designed a new splicing reporter plasmid suitable for analysis in mammalian cells. Our reporter is based on splicing of the GFP sequence. The greatest advantages of this system are the ease of visualization of the splicing reaction, which needs only a fluorescence microscope, and the possibility of quantification of splicing efficiency using real-time PCR. The use of this system allows rapid and easy detection of the splicing reactions.
A New Survival Prediction Model for Patients with Synchronous Colorectal Carcinomas Based on SEER
Authors: Xu YuXin , Wang XiaoJie , Huang Ying , Ye DaoXiong , Chi Pan
Published: April 2020

Introduction

The nomogram for postoperative prediction of overall survival (OS) in patients’ synchronous colorectal carcinomas (SCC) was developed and validated by LASSO regression combined with COX regression.

Methods

The data was obtained from the SEER database of patients diagnosed with colorectal cancer (CRC) more than one time between 2004 and 2013. The cut-off points for the continuous variable were identified by the K-adaptive partitioning algorithm and x-tile software. Using LASSO regression combined with the Cox regression, a model for predicting the overall survival of SCC was built, internally and externally validated, and measured through a calibration curve, C-index, AIC, BIC, IDI, NRI, timeROC, timeAUC, and decision curve analysis (DCA), and results compared to the model developed by the Cox regression.

Results

Patients with SCC were found to be older, more often men, and likely to have a depth of invasion by T3. In addition, there were no significant differences between the model developed by LASSO regression combined with Cox regression and the Cox regression in the calibration curve, C-index, AIC, BIC, IDI, NRI, timeROC, and DCA. Besides, the model developed by LASSO regression combined with Cox regression was found to perform better than the Cox regression in the timeAUC. Moreover, the model developed by LASSO regression combined with Cox regression showed good calibration, C-index, AIC, BIC, IDI, NRI, timeROC, timeAUC and had a larger net benefit compared to both the first time TNM staging and the combination of two times TNM staging.

Discussion

This present study indicates that a close follow-up of older patients, male, and T3 should be made. LASSO regression combined with COX regression decreases the variables of the model, avoids overfitting and collinearity and has clinical significance.
High-risk factors for ipsilateral lateral neck lymph node metastasis in clinically node-negative patients with papillary thyroid microcarcinoma (cT1aN0)
Authors: ZHOU BIN , WEI LIN , QIN JIANWU
Published: April 2020

Background: The incidence of papillary thyroid microcarcinoma (PTMC) increases yearly. There are several studies on the high-risk factors for lymph node metastasis in the central compartment of PTMC but few studies on the high-risk factors for lateral neck lymph node (LNLN) metastasis. Few studies have analyzed the high-risk factors for LNLN metastasis for clinically lymph node-negative PTMC patients in stage T1a (cT1aN0). We investigated the risk factors for LNLN metastasis in these patients.Methods: In total, 127 PTMC (cT1aN0) patients underwent hemi- or total thyroidectomy with ipsilateral central lymph node dissection (CLND) plus lateral lymph node dissection (LLND), including levels III and IV, between 2018 and 2019 in our hospital. Univariate and multivariate analyses identified the high-risk factors for LNLN metastasis in PTMC (cT1aN0).Results: The rate of LNLN metastasis was 21.26% (27/127). The multivariate analysis showed that capsular invasion (p=0.027), tumor location at the superior pole (p=0.002) and ipsilateral central lymph node positivity (p=0.001) were independent risk factors for LNLN metastasis in PTMC patients (cT1aN0), with odds ratios (ORs) of 0.181 (95% confidence interval (95% CI): 0.039-0.827), 5.994 (95% CI: 1.949-18.435) and 6.182 (95% CI: 2.193-17.425), respectively.Conclusions: These findings indicate that capsular invasion, tumor location at the superior pole and ipsilateral central lymph node positivity are independent high-risk factors for LNLN metastasis in clinically node-negative PTMC (cT1aN0) patients. High-risk factors should be correctly evaluated to guide surgical treatment for PTMC patients.
Evidence for circulating microRNA hsa-let-7d-3p as a potential new biomarker for sepsis in human subject
Authors: Zhang Zhaorui , Luo Hailun , Li Chunsun , Liang Zhixin
Published: April 2020

Background: Current biomarkers for early detection of sepsis have low sensitivity and specificity. Serum microRNAs (miRNAs) have been proposed as novel non-invasive biomarkers for various diseases. The aim of the present study was to discover a novel diagnostic biomarker for sepsis in human subjects. Methods: miRNA expression profile was performed using peripheral blood from three sepsis patients in sepsis stage and condition improved stage using microarray screening. The differentially expressed miRNAs were primary validated by real-time quantitative polymerase chain reaction (qRT-PCR) in a further set of 20 sepsis patients in the sepsis stage and condition improved stage. We finally validate the different expressed miRNA in 95 sepsis patients and 66 non sepsis patients. The validated miRNAs along with patients’ clinical indictors were analyzed in a multivariate logistic regression model. The diagnosis value of the changed miRNA in sepsis was determined and compared with CRP and WBC by analyzing the receiver operating characteristic (ROC) curves. Results: According to the criteria we detected 3 miRNAs up regulated and 8 miRNAs down regulated by miRNA chip. qRT-PCR detection showed that the expression of hsa-let-7d-3p in sepsis patient was up regulated compared with non-sepsis patients. In a multiple logistic regression analysis, serum miRNA hsa-let-7d-3p was found to be independent predictor of sepsis. Receiver operating characteristic curve (ROC) analysis showed that the area under ROC curve of serum miRNA hsa-let-7d-3p was 0.696 (95% confidence interval [0.615, 0.778]). Conclusion: miRNA hsa-let-7d-3p was identified as novel biomarkers for the early detection of sepsis.
Phytochemical Profile and in vitro and in vivo Anticonvulsant and Antioxidant Activities of Epilobium hirsutum
Authors: DZHAFAR Sara , DALAR Abdullah , MÜKEMRE Muzaffer , EKİN Suat , YILDIZ Damla , YUNUSOĞLU Oruc
Published: April 2020

﻿This study presents the phytochemical profile and in vitro and in vivo anticonvulsant and antioxidant activities of Epilobium hirsutum, which has been traditionally used in the treatment of epilepsy by local people of Turkey. In vitro studies revealed that the extract contained a pronounced amount of phenolics (206.3±0.9 mg Gallic acid Eq/g extract) and exhibited significant levels of antioxidant (FRAP; 6226 µmol Fe2+/g extract, ORAC; 6593 µmol Trolox Eq/g extract, DPPH; IC50:33.8 ug/mL and metal chelation; IC50:114 ug/mL) and anticonvulsant (AChE; IC50:71.2 ug/mL, BChE; IC50:92.5 ug/mL, GABA-T; IC50:94.7 ug/mL) activities. In vivo studies shown that the extract exhibited high anticonvulsant activities. In addition, the extracts regulated the behaviour, locomotion and mental activities of the mice tested. Biochemical evaluation of the brain tissue revealed that the extract inhibited the production of MDA and stimulated the increasing of antioxidant enzyme levels, which suggest the possible antioxidative role of the extract that worked as neuroprotective agents by scarfing the free radicals produced through PTZ seizure inducer and attenuate convulsions. Moreover the extract regulated serum biochemical parameters, total antioxidant, total oxidant, and ischemia-modified albumin levels. Chromatographic studies were revealed that gallic acid principally might be the major contributor of anticonvulsant and antioxidant activities with the additive contributions of fatty acids and mineral compounds. Findings obtained from this study partially justified the traditional use of Epilobium hirsutum in the treatment of epilepsy and suggest potential use of the extract as industrial or pharmaceutical agent.
Conceptual analysis and normative inquiry in sport
Authors: Morgan William J.
Published: April 2020

Klasična definicija igre i sporta Bernarda Suitsa uzima se kao značajno filozofsko postignuće. Po pitanju njegova definicijskog rada, slažem se s takvim hvalećim pogledom. No u ovom eseju upozoravam na rastuću tendenciju u literaturi iz filozofije sporta da se Suitsove definicije ovih ključnih koncepcija površno uzimaju i kao metafizičko postignuće, kao otkriće prave biti igre i sporta. Svoju kritičku pozornost usmjeravam na nedavni primjer takvih metafizičkih pretjerivanja, na razmatranje igre Colina McGinna u njegovu djelu Truth by Analysis: Games, Names, and Philosophy. Argumentiram da je McGinnova metafizička interpretacija Suitsove konceptualne analize igre i sporta nevaljala i ispitujem negativne normativne posljedice interpretiranja Suitsa na taj način.
CRISPR-Cas9, A Promising Therapeutic Tool for Cancer Therapy: A Review
Authors: Akram Fatima , Ikram ul Haq  , Ahmed Zeeshan , Khan Hamza , Ali Muhammad Shrafat
Published: April 2020

Cancer is one of the most leading causes of mortality all over the world and remains a
foremost social and economic burden. Mutations in the genome of individuals are taking place
more frequently due to the excessive progress of xenobiotics and industrialization in the present
world. With the progress in the field of molecular biology, it is possible to alter the genome and to
observe the functional changes derived from genetic modulation using gene-editing technologies.
Several therapies have been applied for the treatment of malignancy which affect the normal body
cells; however, more effort is required to develop vsome latest therapeutic approaches for cancer
biology and oncology exploiting these molecular biology advances. Recently, the Clustered Regularly
Interspaced Short Palindromic Repeats (CRISPR) associated protein 9 (Cas9) system has
emerged as a powerful technology for cancer therapy because of its great accuracy and efficiency.
Genome editing technologies have demonstrated a plethora of benefits to the biological sciences.
CRISPR- Cas9, a versatile gene editing tool, has become a robust strategy for making alterations to
the genome of organisms and a potent weapon in the arsenal of tumor treatment. It has revealed an
excellent clinical potential for cancer therapy by discovering novel targets and has provided the
researchers with the perception about how tumors respond to drug therapy. Stern efforts are in
progress to enhance its efficiency of sequence specific targeting and consequently repressing offtarget
effects. CRISPR-Cas9 uses specific proteins to convalesce mutations at genetic level. In
CRISPR-Cas9 system, RNA-guided Cas9 endonuclease harnesses gene mutation, DNA deletion or
insertion, transcriptional activation or repression, multiplex targeting only by manipulating
20-nucleotide components of RNA. Originally, CRISPR-Cas9 system was used by bacteria for
their defense against different bacteriophages, and recently this system is receiving noteworthy
appreciation due to its emerging role in the treatment of genetic disorders and carcinogenesis.
CRISPR-Cas9 can be employed to promptly engineer oncolytic viruses and immune cells for
cancer therapeutic applications. More notably, it has the ability to precisely edit genes not only in
model organisms but also in human being that permits its use in therapeutic analysis. It also plays a
significant role in the development of complete genomic libraries for cancer patients. In this
review, we have highlighted the involvement of CRISPR-Cas9 system in cancer therapy accompanied
by its prospective applications in various types of malignancy and cancer biology. In addition,
some other conspicuous functions of this unique system have also been discussed beyond
genome editing.
Antithrombotic Therapy in Patients with Recent Stroke and Atrial Fibrillation
Authors: Saberwal Bunny , Ioannou Adam , Lim Wei Y. , Beirne Anne-Marie , Chow Anthony W. , Tousoulis Dimitris , Ahsan Syed , Papageorgiou Nikolaos
Published: April 2020

:

Atrial fibrillation (AF) is a common arrhythmia which carries a significant risk of stroke. Secondary
prevention, particularly in the acute phase of stroke with anti-thrombotic therapy, has not been validated. The aim
of this review is to evaluate the available evidence on the use of antithrombotic therapy in patients with recent
stroke who have AF, and suggest a treatment algorithm for the various time points, taking into account both the
bleeding and thrombosis risks posed at each stage.
Antithrombotic Treatment after Atrial Fibrillation Ablation
Authors: Antoniou Christos-Konstantinos , Manolakou Panagiota , Arsenos Petros , Dilaveris Polychronis , Gatzoulis Konstantinos , Tousoulis Dimitrios
Published: April 2020

:

Atrial fibrillation is a major cause of debilitating strokes and anticoagulation is an established and indispensable therapy for reducing their rate. Ablation of the arrhythmia has emerged as a putative means of disrupting its natural course by isolating its triggers and modifying its substrate, dependent on the chosen method. An important dilemma lies in the need for continuation of anticoagulation therapy in those previously receiving it following an, apparently, successful intervention, purportedly preventing arrhythmia recurrence with considerably high rates. Current guidance, given scarcity of high-quality data from randomized trials, focuses on established knowledge and recommends anticoagulation continuation based solely on estimated thromboembolic risk. In the present review, it will be attempted to summarize the pathophysiological rationale for maintaining anticoagulation post-successful ablation, along with the latter’s definition, including the two-fold effects of the procedure per se on thrombogenicity. Available evidence pointing to an overall clinical benefit of anticoagulation withdrawal following careful patient assessment will be discussed, including ongoing randomized trials aiming to offer definitive answers. Finally, the proposed mode of post-ablation anticoagulation will be presented, including the emerging, guideline-endorsed, role of direct oral anticoagulants in the field, altering cost/benefit ratio of anticoagulation and potentially affecting the very decision regarding its discontinuation.
A Routing Model for Hybrid Hub-and-Spoke with Time Windows
Authors: Gunadi Felix Arya , Lesmono Dharma , Aritonang Kinley
Published: April 2020

Currently, the company competition is getting tighter. Distribution companies need to provide excellent service to their customers to maintain their competitiveness. Distribution service performance could be measured with lead time. However, Reducing lead times may increase costs. This problem could be solved using freight consolidation and reducing backhaul. Freight consolidation can be done by using a hub-and-spoke network with a combination of inbound and outbound distribution. This study developed a route model for hybrid hub-and-spoke with time windows. This model determined the routes for shipping goods to consumers and taking products to suppliers using the same vehicle to reduce the backhaul. This model also conducted freight consolidation at the hub. The decision variables in this model included the routes of delivery to consumers, the collection of goods at the suppliers, the number of products distributed through the hub and direct shipping, and the excellent distribution route. This model was implemented into the problems. Besides, a sensitivity analysis of the model was carried out.
Integrated ANP and TOPSIS Method for Supplier Performance Assessment
Authors: Natalia Christine , Surbakti Ita Primsa , Oktavia Chendrasari Wahyu
Published: April 2020

A supplier has become one of the main factors that influence a company's supply chain activities. Supplier assessment is vital as suppliers have different performance. This study aims at assessing supplier performance using the integration of ANP and TOPSIS methods. Supplier performance assessment was based on supplier criteria indicators. The weighting criteria used ANP was used to determine the most significant influence criteria of supplier performance. Furthermore,  TOPSIS was also employed to obtain supplier preference. Eight criteria and twenty-five sub-criteria were used for the supplier performance assessment.  The three highest sub-criteria were specification of quality, the flexibility of order changes, and production capacity. The priority results for suppliers were sorted from the highest to lowest ratio values.
PENGARUH DISIPLIN KERJA, PENGALAMAN KERJA DAN PENDIDIKAN KARYAWAN TERHADAP PROMOSI JABATAN PADA SWALAYAN EMBAH;E MURAH PONOROGO, MADIUN DAN MAGETAN
Authors: Andriani Dwi Ayu
Published: April 2020

Metode survey dipilih sebagai sumber data primer diperoleh melalui kuesioner. Populasi dalam penelitian ini adalah seluruh karyawan Swalayan Embah’e Murah jl. Raya Sampung, Ds. Sumoroto Kec. Kauman Kab. Ponorogo, jl. Raya Barat Maospati, Madiun dan jl. -Raya Takeran, Magetan. Sampel yang digunakan sebanyak 60 responden. Uji instrumen dengan uji validitas dan uji reliabilitas. Teknik bahwa: (1) Disiplin kerja tidak pengaruh terhadap promosi jabatan dengan t-hitung sebesar 0,200 < t-tabel 2,003 dan tingkat signifikan 0,842. (2) Pengalaman kerja tidak pengaruh terhadap promosi jabatan dengan t-hitung -0,608 <  t-tabel 2,003 dan tingkat signifikan 0,546. (3) Pendidikan karyawan tidak berpengaruh terhadap promosi jabatan dengan t-hitung 1,521 < t-tabel 2,003 dan tingkat signifikan 0,134. (4) Disiplin Kerja, PengalamanmKerja dan Pendidikan Karyawan tidak berpengaruh terhadap promosi jabatan dengan nilai f-hitung 0,882 < f-tabel 2,54 dan tingkat signifikan 0,456. (5) Besarnya kemampuan model dalam menerangkan variabel Disiplin kerja, Pengalaman Kerjaidan Pendidikan karyawan terhadap Promosi Jabatan (adjusted ) adalah sebesar 4,5%. Persamaan regresi linear berganda diperoleh Y = 14,357+ 0,019 +  (-0,072) +  0,219Kata Kunci : Disiplin Kerja, Pengalaman Kerja, Pendidikan Karyawan dan Promosi
La libertad y su realización. La antropología de la Filosofía del Derecho
Authors: Amengual Coll Gabriel
Published: April 2020

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El sentido del reconocimiento como formación del espíritu en Hegel
Authors: De la Maza Luis Mariano
Published: April 2020

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Realismo y teoría cuántica
Authors: Diéguez Antonio J.
Published: April 2020

RESUMENLos resultados empíricos y los análisis teóricos en física cuántica ni apoyan ni refutan concluyentemente el realismo. Aunque se mostrara que la interpretación de Copenhague era la única viable de entre todas las posibles, todavía quedaría por probar que con eso se había conculcado cualquier tipo de realismo. Bohr mismo aceptaba un realismo con tintes kantianos y mostraba desagrado hacia el instrumentalismo de Heisenberg. Pero además de la interpretación de Copenhague existen interpretaciones rivales que, a pesar de no estar tan desarrolladas como aquélla, dejan abierto el camino al realismo en la física cuántica. En particular la interpretación de David Bohm.PALABRAS CLAVEREALISMO CIENTIFICO – TEORIA CUANTICA – LOCALIDADABSTRACTThe empirical achievements and theoretical analyses in quantum physics neither support nor refute conclusively realism. Even if it were shown that Copenhagen Interpretation is the only feasible one between all the possible interpretations in quantum mechanics, it would remain to prove that it forbids every kind of realism. In fact, Bohr himself accepted a realism with Kantian aspects and disagreed whith Heisenberg’s instrumentalism. But there are interpretations, rival to Copenhagen’s, which in spite of not being son developped, smooth the way for realism in quantum physics. Particularly David Bohm’s interpretation.KEYWORDSSCIENTIFIC REALISM – QUANTUM THEORY – LOCALITY
Evaluación de desenlaces clínicos y paraclínicos por medio de la aplicación del PERFSCORE a pacientes con diagnóstico de infarto agudo de miocardio, que completaron fase II y III de rehabilitación cardiaca en el Hospital Militar Central durante el año 2016
Authors: Cabezas García Ligia , Álvarez Fernández Oscar
Published: April 2020

Se realizó un estudio observacional de corte transversal, que evaluó el desempeño del programa de rehabilitación cardiaca del Hospital Militar Central de Bogotá, por medio de la aplicación del PERFSCORE a pacientes con infarto agudo de miocardio (IAM) que durante el año 2016 ingresaron y culminaron fase II y III de rehabilitación cardiaca.

Materiales y métodos: Estudio observacional de corte transversal que incluyó 183 pacientes con diagnóstico de IAM, que requirieron manejo percutáneo o quirúrgico. La muestra fue observada al ingreso y 9 meses después de culminar fase III, se observaron variables clínicas y paraclínicas al ingreso y egreso que fueron analizadas por estadística descriptiva; así mismo se calculó el PERFSCORE que puntúa el desempeño del programa en óptimo (mayor que 28), satisfactorio (entre 22 y 28) o insatisfactorio (menor que 22).

Resultados: Se reunieron 75 pacientes que cumplieron los criterios de inclusión. Dentro de las variables de interés, se observó que hubo cambios a favor del control satisfactorio de las cifras basales de frecuencia cardiaca, tensión arterial y niveles de LDL. Así mismo, 58 pacientes (que corresponden al 77% de la muestra) obtuvieron un PERFSCORE superior a 28.

Conclusiones: Se resalta la importancia de una evaluación objetiva del desempeño de los programas de rehabilitación cardiaca como una estrategia de seguimiento a pacientes y mejoramiento de estos programas.
Coste de la discapacidad en España: perspectivas futuras de la Organización Mundial de la Salud
Authors: Carmona-Espejo Antonio , González-Villén Raquel
Published: April 2020

En la actualidad, la discapacidad supone una cuestión socioeconómica difícil de abordar en todo su espectro. Se estima que en España el 6,1% de la población sufre algún tipo de discapacidad; sin embargo, según la Organización Mundial de la Salud, esta cifra es de alrede- dor del 15% a nivel mundial. En este sentido, es prioritario lograr un adecuado equilibrio que proporcione recursos económicos y sociales a este sector poblacional y que garantice su inte- gración social de manera completa y equitativa.
Abordaje fisioterapéutico de paciente con meningomielocele, polimicrogiria y siringomielia
Authors: Castro-Galeano Sandra Milena
Published: April 2020

Se describe el resultado de la intervención fisioterapéutica aplicada a una niña después de cirugía de corrección de malformación de la médula espinal. En el procedimiento quirúrgico se le realizó descompresión del canal raquídeo, resección de lipoma extradural e intradural y corrección de lipomeningomielocele y médula anclada con monitoreo neurofisio-lógico. La paciente había sido diagnosticada con polimicrogiria y siringomielia clasificación ASIA A y fue tratada con abordaje fisioterapéutico basado en método Vojta durante el primer año de vida, que luego se complementó con electroterapia. El objetivo de la intervención con tratamiento Vojta fue desbloquear los circuitos de la médula y el cerebro para lograr un adecuado funcionamiento del sistema nervioso central y, de esta forma, regular el tono muscular, la comunicación y las funciones musculares. Después de dos años y medio de tratamiento se logró marcha con adecuado patrón motor, lenguaje completo, escolarización, disminución en el número de cateterismos, control completo de esfínteres y clasificación ASIA E.
Suvremeni izazovi u provođenju socijalne politike s posebnim naglaskom na mjere socijalne intervencije
Authors: Smokvina Vanja , Čunčić Magdalena
Published: April 2020

Autori u radu ističu važnost socijalnih intervencija kao mjera socijalne politike u svladavanju izazova suverenoga društva. Naglasak je dan na mjere poput dječjeg doplatka, naknada za roditeljski dopust, subvencioniranje stambenih kredita mladih obitelji te druge mjere pronatalitetne i obiteljske politike ne samo na državnoj, već i na lokalnoj razini.
macam-macam definisi audit
Authors: karina santy
Published: April 2020

macam-macam definisi audit
Lia_Aulina_165100113
Authors: aulina Lia
Published: April 2020

Proses pengembangan system yaitu seperangkat aktivitas, metode, dan praktik dan alat-alat terotomatisasi yang digunakan untuk meningkatkan dalam pengembangan sistem dan software.Pada awal berkembangnya system informasi, pengembangan system informasi dilakukan oleh programmer. Manajemen perusahaan (user) meminta kepada programmer untuk membuatkan program tertentu yang bisa membantu aktivitasnya. Deangan permintaan tersebut programmer akan meminta data yang harus dimasukkan dan laporan atau informasi yang ingin dikeluarkan, berdasarkan data dan laporan inilah programmer mulai dan bekerja. Hasil akhir dari pekerjaan ini ternyata informasi yang dihasilkan tidak memuaskan dan saat itulah muncul pemikiran perlu adanya analisis sebelum sistem informasi dirancang, dan lahirlah satu metode pengembangan sistem informasi.Kata Kunci : Proses Pengembangan Sistem.
Resume_Sistem Informasi oleh-oleh Lampung
Authors: SUTRIYANI
Published: April 2020

Sisstem Informasi UMKM oleh-oleh lampung berbasis web merupakan web yang membantu para umkm agar dapat memasakan hasil dari penghasilannya agar dapat meningkatkan penjualannya dan dapat memasakan barang dagangannya.
Synthesis of Manganese Oxide Nanoparticles in Premixed Flames
Authors: Dasappa Shruthi , Camacho Joaquin
Published: April 2020

See also: CrystEngComm (2020) 22, 5509-5521"Formation of nanocrystalline manganese oxide in flames: oxide phase governed by classical nucleation and size-dependent equilibria" by Shruthi Dasappa and Joaquin CamachoSynthesis of manganese oxide nanoparticles was carried out in premixed stagnation flames. The deposition surface was stationary to enable rigorous comparison to flame structure computations using pseudo one-dimensional and full two-dimensional calculations. The pseudo one-dimensional assumption taken by OPPDIF to calculate the flame structure performs reasonably well for the narrow aspect ratio stagnation flow currently studied. Agreement between the measured flame position and both computational methods was within 0.25 cm. The variation in manganese oxidation state in the products observed here is shown to be caused by competing oxidation and particle nucleation processes. Complimentary experimental and modeling studies of flame synthesis were carried out under well-defined boundary conditions to examine this competition. Manganese oxide products having II, II,III, III and IV valence were observed depending on the flame conditions. Unlike iron oxide and titanium oxide systems, complete oxidation to MnO2 is only observed for the most oxidizing growth conditions. The first observation of phase pure MnO by flame synthesis is reported here. Manipulation of the balance between manganese oxidation and particle nucleation through control of the time-temperature-oxygen history may enable selective synthesis of manganese oxide nanoparticles with tailored morphology and oxidation state.
Effective infection prevention and control strategies in a large accredited psychiatric facility in Singapore
Authors: Poremski Daniel , Subner Sandra Henrietta , Kin Grace Lam Fong , Dev Raveen Dev Ram , Ming Mok Yee , Choon Chua Hong , Fung Daniel S.S.
Published: April 2020

The Institute of Mental Health in Singapore continues to attempt to prevent the introduction of COVID-19, despite community transmission. Essential services are maintained and quarantine measures are currently unnecessary. To help similar organizations, strategies are listed along three themes: sustaining essential services, preventing infection, and managing human and consumable resources.
The Influences of Category Learning on Perceptual Reconstructions
Authors: Dubova Marina , Goldstone Robert
Published: April 2020

We explore different ways in which the human visual system can adapt for perceiving and categorizing the environment. There are various accounts of supervised (categorical) and unsupervised perceptual learning, and different perspectives on the functional relationship between perception and categorization. We suggest that common experimental designs are insufficient to differentiate between hypothesised perceptual learning mechanisms and reveal their possible interplay. We propose a relatively underutilized way of studying potential categorical effects on perception, and test the predictions of different perceptual learning models using a two-dimensional, interleaved categorization-plus-reconstruction task. We find evidence that human visual encodings adapt to the feature structure of the environment, allocate encoding resources with respect to categorization utility, and adapt to prevent miscategorizations.
Evaluating Bayesian radiocarbon-dated event-count [REC] models for the study of long-term human and environmental processes
Authors: Carleton William Christopher
Published: April 2020

Chronological uncertainty complicates attempts to use radiocarbon dates as proxies for processes like human population growth/decline, forest fires, and marine ingression. Established approaches involve turning databases of radiocarbon-date densities into single summary proxies that cannot fully account for chronological uncertainty. Here, I use simulated data to explore an alternate Bayesian approach that instead models the data as what they are, namely radiocarbon-dated event-counts. The approach involves assessing possible event-count sequences by sampling radiocarbon date densities and then applying MCMC to estimate the parameters of an appropriate count-based regression model. The regressions based on individual sampled sequences were placed in a multilevel framework, which allowed for the estimation of hyperparameters that account for chronological uncertainty in individual event times. Two processes were used to produce simulated data. One represented a simple monotonic change in event-counts and the other was based on a real palaeoclimate proxy record. In both cases, the method produced estimates that had the correct sign and were consistently biased toward zero. These results indicate that the approach is widely applicable and could form the basis of a new class of quantitative models for use in exploring long-term human and environmental processes.
Carcinoma basocelular como debut por exposición al sol.
Authors: Álava Cedeño María Susana , Herrera Álava José Carlos , Montesdeoca Chancay Andrea Lissette , Macías Palma Andrea Jamileth , Quijije Roldán Julexi Tatiana
Published: April 2020

Introducción: Es reconocida la importancia de la luz solar para la evolución de la vida en la tierra y su papel en el desarrollo humano. Sin embargo, todos los humanos, especialmente las personas cuya piel no está tan pigmentada o cuya ocupación o estilo de vida los expone a cantidades excesivas de luz solar, son potencialmente susceptibles a sus efectos nocivos. Es indiscutible el vínculo entre la exposición crónica al sol de la piel humana y las consecuencias clínicas nocivas como el fotoenvejecimiento y los cánceres de piel, como es el carcinoma basocelular.

Objetivo: Describir el efecto que tiene la exposición prolongada al sol como factor de riesgo para desarrollar Carcinoma Basocelular.

Material y métodos: Estudio descriptivo retrospectivo, presentación de caso clínico de Carcinoma Basocelular por exposición al sol

Resultados: Existieuna asociación entre la exposición  excesiva a  radiaciones solares  por el paciente y la aparición de un carcinoma basocelular en la piel.

Conclusiones: El Carcinoma Basocelular representa la neoplasia cutánea más frecuente, por lo cual se hace imprescindible para lograr el correcto diagnóstico y tratamiento,  conocer su comportamiento clínico y evolución de la lesión. El factor de riesgo más importante a considerar es el tiempo de exposición a los rayos solares.
Effect of Active Learning in Form of Scientific Approach with Assistance of Student Worksheets Based Problem Based Learning (PBL) Towards Students Biology Psychomotor Competence in Bacterial Material
Authors: Lufri Lufri , Laili Fitria , Anhar Azwir
Published: April 2020

In the 2013 curriculum, students are demanded to be active in learning process. To actualize it, teacher should has adequate ability and skills by implementing appropriate learning model in teaching. Purpose of the research was to know effect of Active Learning in form of scientific approach with assistance of student worksheets based Problem Based Learning to wards students' Biology competence in Bacterial material.  The research method used a quasi experimental research by using randomized control posted only design. The population was students in grade X MIPA of SMAN 1 Pasaman registered in academic  year 2018/2019. Samples were taken by using Purposive Sampling technique. Instrument used was psychomotor competence observation sheet. Data analysis was conducted by using Mann Whitney U test. The finding showed that there is a significant difference between students' biology competence in experimental class and control class, in which students' biology competence in experimental class is higher than in control class. Average score of students' biology competence in experimental class is 3.34 (B+) and in control class is 3.17 (B). So, it can be concluded that Active Learning in form of scientific approach with assistance of student worksheets based Problem Based Learning can improve students Biology competence.
Chrystianizacja i romanizacja elit w rzymskiej Edessie
Authors: Jędrzejewska Daria
Published: April 2020

W przedrzymskiej historii Edessy i Osrhoene wyraźnie rysowała się rola lokalnych elit, skupionych wokół królewskiego dworu. Warstwa ta była silnie przesiąknięta kulturą irańską. W procesie przechodzenia Osrhoene do rzymskiej strefy wpływów, elity Edessy przejmowały do pewnego stopnia rzymskie wzorce kulturowe, zaś ich przedstawiciele piastowali stanowiska w lokalnej administracji już po upadku dynastii Abgarydów w 242 roku po Chr. Niniejszy artykuł ma na celu prześledzenie w źródłach dotyczących historii Edessy wzmianek na temat lokalnej arystokracji. Wskazują one, że warstwa ta nadal odgrywała pewną rolę po zamianie królestwa w prowincję, pozostając jednak w cieniu coraz prężniej rozwijającego się ascetycznego nurtu syryjskiego chrześcijaństwa. Z elitami Edessy związana jest postać Bar Daisana, którego nauki i sekta zwana Bardezanitami przetrwały co najmniej do V wieku; prawdopodobnie te same kręgi przechowywały i modelowały przekaz o nawróceniu króla Edessy (teoria S. Brocka), który została przyjęty przez ogół mieszkańców miasta. Mimo iż zachowane źródła wzmiankują elity Edessy niechętnie i zdawkowo, najważniejsza ze związanych z nimi tradycji – legenda o nawróceniu miasta – stała się czynnikiem, który rozsławił Edessę w rzymskim świecie.
Geneza „dwóch Testamentów” Pisma Świętego
Authors: Królikowski Janusz
Published: April 2020

W codziennym języku chrześcijańskim i w teologii posługujemy się określeniami Stary i Nowy Testament w odniesieniu do dwóch części Pisma Świętego. Język ten posiada źródła biblijne, ale ukształtował się stopniowo w refleksji pierwotnego Kościoła. Wynikało to zarówno z poszukiwania przez wspólnotę chrześcijańską własnej tożsamości, jak i z faktu, że częścią tej tożsamości stawały się „nowe” Pisma. Zachodziła więc potrzeba określenia ich relacji do Pism żydowskich oraz ich specyfiki, która pozostawała pod znakiem wypełnienia tego, co stare. Artykuł zamierza pokazać, w jaki sposób narodziła się koncepcja „dwóch Testamentów” w pierwotnym Kościele.
Obrona dziewicy Indycji okazją do pouczenia o cnocie dziewictwa - list św. Ambrożego do Syagriusza (Ep. 56)
Authors: Ostrowski Grzegorz
Published: April 2020

Ambrogio, vescovo di Milano, e noto nella storia della Chiesa come pastore e difensore della verginita. Le sue lettere contengono tanti preziosi insegnamenti di natura pratica e morale. In questo articolo ci siamo concentrati sulla lettera a Siagrio (Epistula 56), nella quale difende la vergine Indicia, ingiustamente accusata di non aver rispettato il voto di castita. Nello stesso tempo ci offre un insegnamento sulla verginita. Ambrogio pone l’attenzione sulla dimensione fisica della verginita. Da peró la priorita all'importanza della verginita spirituale rispetto a quella fisica, perche in essa si esprime un legame amoroso con Cristo. La verginita fisica e solo l’espressione di quello che la vergine vive dentro di se . E tutto 1’insegnamento di Ambrogio e visto in questa ottica.
Implementasi E-learning Dengan Model Flipped Classroom Dalam Aktivitas Belajar Siswa Pada Mata Pelajaran Sistem Komputer
Authors: Bariyah Siti Husnul
Published: April 2020

Penelitian ini bertujuan untuk mengimplementasikan E-Learning dengan model Flipped Classroom dalam aktivitas belajar siswa pada mata pelajaran sistem computer. Dilatar belakangi  atas kurangnya aktivitas belajar siswa pada mata pelajaran sistem komputer kelas X Multimedia. Metode yang digunakan dalam penelitian ini adalah Mixed Methods atau metode yang menggabungkan antara kuantitatif dengan kualitatif dengan menggunakan strategi sequential mixed methods. Populasi dalam penelitian ini adalah seluruh siswa kelas X sebanyak 3 Kelas Semester 1 SMK Negeri 9 Garut dengan sampel yang diambil 1 kelas yaitu kelas X MM 1 sebanyak 32 siswa. Teknik pengumpulan data dilakukan dengan tes hasil belajar, dan angket yang diberikan kepada siswa maupun guru. Hasil penelitian dan analisis data diketahui bahwa kemampuan aktivitas belajar siswa pada mata pelajaran sistem komputer dengan materi sistem bilangan menunjukan dengan persentase ketuntasan belajar sebanyak 75%, menunjukan rasa ketertarikan 77%, rasa keingintahuan 78%, rasa senang 58%, rasa keaktifan 65%, rasa perhatian 58%.Kata Kunci : aktivitas belajar siswa, media pembelajaran e-learning, Flipped Classroom.
Populismo e ciências sociais brasileiras:
Authors: Gentile Fabio
Published: April 2020

Ao longo do caminho trilhado para obter os resultados mais significativos no debate pertinente, este artigo proporciona um panorama analítico, histórico-crítico e metodológico, embora não exaustivo, dos usos (e também dos abusos) do conceito de populismo nas ciências sociais brasileiras – tendo em vista que estas constituem um verdadeiro laboratório da apropriação latino-americana do populismo. Se, por um lado, o debate brasileiro incorpora todos os pontos fortes e fracos do debate europeu e norte-americano sobre o populismo, a adoção desse conceito no pensamento político-social brasileiro, por outro lado, deve atender a algumas necessidades específicas, a partir das primeiras teorias sobre o povo “amorfo”, entre a segunda metade do século XIX e o início do século XX, passando pela análise do ciclo nacional-desenvolvimentista da “Era Vargas” (no período de 1930 a 1964), até chegar à recuperação desse conceito nas últimas décadas, para definir o fenômeno do “lulismo” e, sobretudo, o chamado “bolsonarismo”, já no século XXI.
Convocatoria de autores para número monográfico: La construcción de un nuevo paradigma post pandemia
Authors: Gómez Oscar R.
Published: April 2020

La Revista Científica Arbitrada de la Fundación MenteClara Internacional (RCAFMC) convoca a la presentación de trabajos de investigación enfocados en la construcción de un nuevo paradigma de sujeto y las consecuencias individuales, sociales, políticas y económicas de la pandemia COVID-19 que busquen responder, entre otras, a las siguientes preguntas: ¿Qué inequidades se visibilizaron con la pandemia?, ¿Qué nuevos derechos se constituyeron?, ¿Cuál es el lugar de la filosofía en estos eventos?, ¿Cómo repensar la ciencia y su organización, para responder a estas situaciones?, ¿Qué discursos sociales, políticos, morales y religiosos, sustentaron diversas formas de pensar la pandemia? y ¿Que instrumentos didácticos pueden colaborar en la construcción de un modelo de pensamiento superador del sujeto previo a la pandemia COVID-19? Esta convocatoria tiene como objeto debatir, articular conceptos y producir nuevas herramientas académicas para obtener una visión clara del posible nuevo sistema de pensamiento post pandemia, reuniendo en un foro común a intelectuales de diferentes disciplinas que contribuyan a solucionar las consecuencias del COVID-19 en los individuos y su mundo de relaciones sociales, políticas y económicas.