bluuebunny/crossref_metadata_2025 huggingface dataset:
The inactive X chromosome accumulates widespread epigenetic variability with age
Authors: Liu Yunfeng , Sinke Lucy , Jonkman Thomas H. , Slieker Roderick C. ,   BIOS Consortium, van Zwet Erik W. , Daxinger Lucia , Heijmans Bastiaan T.
Published: August 2023

Background

Loss of epigenetic control is a hallmark of aging. Among the most prominent roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome in females through DNA methylation. Hence, age-related disruption of X-chromosome inactivation (XCI) may contribute to the aging process in women.

Methods

We analyzed 9,777 CpGs on the X chromosome in whole blood samples from 2343 females and 1688 males (Illumina 450k methylation array) and replicated findings in duplicate using one whole blood and one purified monocyte data set (in total, 991/924 females/males). We used double generalized linear models to detect age-related differentially methylated CpGs (aDMCs), whose mean methylation level differs with age, and age-related variably methylated CpGs (aVMCs), whose methylation level becomes more variable with age.

Results

In females, aDMCs were relatively uncommon (n = 33) and preferentially occurred in regions known to escape XCI. In contrast, many CpGs (n = 987) were found to display an increased variance with age (aVMCs). Of note, the replication rate of aVMCs was also high in purified monocytes (94%), indicating an independence of cell composition. aVMCs accumulated in CpG islands and regions subject to XCI suggesting that they stemmed from the inactive X. In males, carrying an active copy of the X chromosome only, aDMCs (n = 316) were primarily driven by cell composition, while aVMCs replicated well (95%) but were infrequent (n = 37).

Conclusions

Our results imply that age-related DNA methylation differences at the inactive X chromosome are dominated by the accumulation of variability.
A novel therapeutic management for diabetes patients with chronic limb-threatening ischemia: comparison of autologous bone marrow mononuclear cells versus allogenic Wharton jelly-derived mesenchymal stem cells
Authors: Arango-Rodríguez Martha L. , Mateus Ligia C. , Sossa Claudia L. , Becerra-Bayona Silvia M. , Solarte-David Víctor Alfonso , Ochoa Vera Miguel Enrique , Viviescas Lady T. Giratá , Berrio Ana M. Vera , Serrano Sergio Eduardo , Vargas Oliverio , Isla Andrés Catalá , Benitez Alape , Rangel Germán
Published: August 2023

Background

Chronic limb-threatening ischemia (CLTI) represents the final stage of peripheral arterial disease. Approximately one-third of patients with CLTI are not eligible for conventional surgical treatments. Furthermore, patients with advanced stage of CLTI are prone to amputation and death. Thus, an effective therapeutic strategy is urgently needed. In this context, autologous bone marrow mononuclear cell (auto-BM-MNC) and allogeneic mesenchymal stem cells represent a promising therapeutic approach for treating CLTI. In this study, we compared the safety and beneficial therapeutic effect of auto-BM-MNC versus allogeneic Wharton jelly-derived mesenchymal stem cells (allo-WJ-MSCs) in diabetic patients with CLTI.

Methods

We performed a randomized, prospective, double-blind and controlled pilot study. Twenty-four diabetic patients in the advanced stage of CLTI (4 or 5 in Rutherford’s classification) and a transcutaneous oxygen pressure (TcPO2) below 30 mmHg were randomized to receive 15 injections of (i) auto-BM-MNC (7.197 × 106 ± 2.984 × 106 cells/mL) (n = 7), (ii) allo-WJ-MSCs (1.333 × 106 cells/mL) (n = 7) or (iii) placebo solution (1 mL) (n = 10), which were administered into the periadventitial layer of the arterial walls under eco-Doppler guidance. The follow-up visits were at months 1, 3, 6, and 12 to evaluate the following parameters: (i) Rutherford’s classification, (ii) TcPO2, (iii) percentage of wound closure, (iv) pain, (v) pain-free walking distance, (vi) revascularization and limb-survival proportion, and (vii) life quality (EQ-5D questionnaire).

Results

No adverse events were reported. Patients with CLTI who received auto-BM-MNC and allo-WJ-MSCs presented an improvement in Rutherford’s classification, a significant increase in TcPO2 values‬, a reduction in the lesion size in a shorter time, a decrease in the pain score and an increase in the pain-free walking distance, in comparison with the placebo group. In addition, the participants treated with auto-BM-MNC and allo-WJ-MSCs kept their limbs during the follow-up period, unlike the placebo group, which had a marked increase in amputation.

Conclusions

Our results showed that patients with CLTI treated with auto-BM-MNC and allo-WJ-MSCs conserved 100% of their limb during 12 months of the follow-up compared to the placebo group, where 60% of participants underwent limb amputation in different times. Furthermore, we observed a faster improvement in the allo-WJ-MSC group, unlike the auto-BM-MNC group.

Trial registration This study was retrospectively registered at ClinicalTrials.gov (NCT05631444).
Sex differences in long-term kidney fibrosis following neonatal nephron loss during ongoing nephrogenesis
Authors: Menendez-Castro Carlos , Cordasic Nada , Fahlbusch Fabian B. , Woelfle Joachim , Hilgers Karl F. , Hartner Andrea
Published: August 2023

Background

Clinical studies suggest that female sex plays a protective role in the development and progression of kidney disease. Recent experimental studies indicate that in male rats early nephron loss under ongoing nephrogenesis is accompanied by severe long-term sequelae. In humans, nephron formation occurs mainly in the third trimester, ceasing with 36 weeks of gestation. Due to perinatal complications, preterm infants delivered during this vulnerable period may undergo acute nephron loss. In rats nephrogenesis persists until postnatal day 10, reflecting the situation of human preterms with persisting nephrogenesis. In our animal model of neonatal uninephrectomy, female and male rats were uninephrectomized at day 1 of life. Hypothesizing sex-dependent differences, long-term renal outcome was assessed after 1 year.

Results

In both sexes, neonatal uninephrectomy was not followed by arterial hypertension at 1 year of age. Compensatory weight gain and glomerular hypertrophy of the remaining kidney occurred in uninephrectomized female and male animals. Selected markers of interstitial inflammation and fibrosis were regulated sex-dependently. The expression of monocyte chemoattractant protein-1 was increased in females, while tubulointerstitial infiltration by M1 macrophages was significantly higher in males after neonatal uninephrectomy. Neonatally uninephrectomized male rats had more glomerulosclerosis and podocyte damage compared to females, which was assessed by a semiquantitative score and desmin staining. RT-PCR revealed that after neonatal uninephrectomy in the remaining contralateral kidney of female rats the expression of candidate genes of renal development and function, i.e., wt-1, nephrin, synaptopodin, gdnf, and itga8 was higher than in males.

Conclusions

Based on these observations we conclude that female sex is protective in the long-term response of the kidney to acute nephron loss under active nephrogenesis.
Review of the genus Sparasion Latreille, 1802 (Hymenoptera: Platygastroidea: Sparasionidae) of the Oriental region with descriptions of new species from India
Authors: Veenakumari Kamalanathan , Polaszek Andrew , Poggi Roberto , Sreedevi Kolla , Mohanraj Prashanth , Khan Farmanur Rahman , Baradevanal Gundappa
Published: August 2023

Background

The genus Sparasion, endoparasitoids of Tettigoniidae, occur in the Nearctic, Palearctic, Afrotropical and Oriental regions. It is absent in the Neotropics and Australasia. Of the thirteen species found in the Oriental region only a single species is from India.

Results

Two new species groups - Sparasion bilahari species group and Sparasion manavati species group - are proposed for species from the Oriental region. Thirty-six species are described and illustrated of which twenty-four are new: Sparasion albopilosellus Cameron, 1906 (Pakistan); S. bhairavi Veenakumari, sp. n. (India); S. bhupali Veenakumari, sp. n. (India); S. bihagi Veenakumari, sp. n. (India); S. bilahari Veenakumari, sp. n. (India); S. cellularis Strand, 1913 (Taiwan); S. coconcus Kozlov and Lê, 2000 (Vietnam); S. coeruleus Kieffer, 1905 (Sumatra); S. cullaris Kozlov and Lê, 2000 (Vietnam); S. darbari Veenakumari, sp. n. (India); S. deepaki Veenakumari, sp. n. (India); S. domes Kozlov and Lê, 2000 (Vietnam); S. elbakyanae Veenakumari, sp. n. (India); S. formosus Kieffer, 1910 (Taiwan); S. hindoli Veenakumari, sp. n. (India); S. kalyani Veenakumari, sp. n. (India); S. kanakangi Veenakumari, sp. n. (India); S. karivadana Veenakumari, sp. n. (India); S. lividus Johnson, Masner & Musetti, 2008 (Philippines); S. manavati Veenakumari, sp. n. (India); S. meghmalhari Veenakumari, sp. n. (India); S. micromerus Kozlov and Lê, 2000 (Vietnam); S. pahadi Veenakumari, sp. n. (India); S. philippinensis Kieffer, 1913 (Philippines); S. ratnangi Veenakumari, sp. n. (India); S. rupavati Veenakumari, sp. n. (India); S. salagami Veenakumari, sp. n. (India); S. shulini Veenakumari, sp. n. (India); S. sinensis Walker, 1852 (China); S. sivaranjini Veenakumari, sp. n. (India); S. syamalangi Veenakumari, sp. n. (India); S. todi Veenakumari, sp. n. (India); S. travancoricus Mani and Sharma, 1981 (India); S. vanaspati Veenakumari, sp. n. (India); S. visvambari Veenakumari, sp. n. (India) and S. zeelafi Veenakumari, sp. n. (India). Keys to Oriental species of Sparasion are furnished. Intrasexual colour morphs among females of Sparasion is reported. Lectotype is designated for Sparasion cellularis Strand.

Conclusions

Twenty-four new species are added to the Indian fauna of Sparasion. Previously described species of Oriental Sparasion are redescribed and illustrated. Keys are furnished for all Oriental species.
Spicy Shiro flour and Berbere powder (an ethnic, indigenous food of Ethiopia)
Authors: Zeru Tesfaye , Awoke Temesgen , Assefa Teshome , Tesfaye Biniyam , G/Giorgies Taddesse , Bitew Abebe , Taddesse Chere , Tesfaye Kelemua , Demelash Yoseph , Yehualashet Asrat , Tefera Nahom , Ashenafi Nigat , W/Yohannes Messeret , Legesse Addisu , Gobene Waqtole , Abera Andinet , Andualem Misganaw , Tessema Masresha
Published: August 2023

Ethiopia is a multiethnic nation with a wide range of cultural traditions, as well as ancient indigenous culinary skills that have made a significant contribution to national and religious holidays, family get-togethers, community celebrations, funeral rites, and economical progress. The most extensively produced and consumed traditional meals in various regions of Ethiopia are Shiro flour and Berbere powder. The significance and reputation of Shiro flour and Berbere powder in Ethiopian culture cannot be overstated. Shiro flour and Berbere powder are consistently the most well-liked and essential components in Ethiopian cuisine. However, research on Shiro flour and Berbere powder was limited, and there was no scientifically compiled data on these food products. As a result, this study was undertaken to collect indigenous knowledge, practices, mode of preparations, and skills, as well as to generate baseline data on Shiro flour and Berbere powder at the national level by examining the physicochemical qualities, this study was conducted. A cross-sectional study design was used, and 220 respondents with prior experience preparing Spicy Shiro flour and Berbere powder took part. The findings of this study will use for interventions such as food supplementation, importing to international markets for revenue generation, setting national and international standards, formulating products, providing students and researchers with reference material, and creating jobs, particularly for young people and women. The bioavailability and recommended amount/dosage of herbs and spices to be added during Shiro flour and Berbere powder preparation, however, has not been studied in Ethiopia. Furthermore, the current study did not address the analysis of antioxidants, aflatoxins content from Berbere powder, amino acid profiles, value addition, and shelf life of both products.
The robust $$H_{\infty }$$ control of stochastic neutral state delay systems
Authors: Ravi Kumar Rajagounder , Naveen R. , Anandhi V. , Sudha A.
Published: August 2023

In this paper, the resilient stochastic neutral state delay system with the Markov chain problem is examined. It offers output feedback control based on discrete state space delay and uncertainty that appear under traditional delay-independent conditions and exist under neutral stochastic state delays. Lyapunov theory can be used to solve the formulation $$x_c(t)=x(t)-Cx(t-\tau )$$

x
c

(
t
)

=
x

(
t
)

-
C
x

(
t
-
τ
)

for the intended $$H_\infty$$

H
∞

control of a stochastic model. Its stochastically mean square stability is shown using linear matrix inequalities (LMIs). The efficiency of the suggested strategy is shown by simulation results.
Prevalence and Risk Factors for Moral Distress in Pediatric Oncology Health Care Professionals
Authors: Mathews Natalie , Alodan Khalid , Kuehne Nathan , Widger Kimberley , Locke Maria , Fung Karen , Gandhi Sheila , McLean Jennifer , Hossain Alomgir , Alexander Sarah
Published: August 2023

PURPOSE

Moral distress (MoD) is prevalent among health care professionals (HCPs) in oncology and is associated with burnout. The objectives of this study were to quantify MoD among pediatric oncology healthcare professionals (HCPs) at a Canadian quaternary care hospital, identify root causes, and evaluate change over time.

METHODS

Eligible pediatric oncology HCPs were identified, and consenting participants completed the Measure of Moral Distress-Healthcare Professionals (MMD-HP) and MoD Thermometer (MDT) at baseline, followed by biweekly MDTs over 12 weeks.

RESULTS

A total of 139 HCPs participated. The mean MMD-HP score was 123 ± 57.0, range 9-288. Demographic risk factors identified for elevated MMD-HP scores were female sex (female 127.1 and male 83.6, P = .01) and nursing role (nurse 136.3 and most responsible physician 85.3, P = .02). Higher MMD-HP scores were found in HCPs who were currently considering resigning because of MoD compared with those who were not (169.9 v 115.4, P < .001). Situations involving administration of treatment to children with poor prognosis cancers that was perceived to be overly aggressive were ranked as the greatest environmental contributor to MoD. Baseline and mean MDT scores over time strongly correlated with MMD-HP scores ( P < .0001 and P = .0003, respectively), with mean MDT scores showing no significant fluctuation over the 12-week period.

CONCLUSION

MoD was common among pediatric oncology HCPs. Risk factors for elevated levels of MoD included both demographic and environmental factors. Implementation of systems to improve team communication and decision making, especially in the care of patients with poor prognosis cancers, may affect HCP MoD.
Efficacy of Immune Checkpoint Inhibition and Cytotoxic Chemotherapy in Mismatch Repair-Deficient and Microsatellite Instability-High Pancreatic Cancer: Mayo Clinic Experience
Authors: Coston Tucker , Desai Aakash , Babiker Hani , Sonbol Mohamad Bassam , Chakrabarti Sakti , Mahipal Amit , McWilliams Robert , Ma Wen Wee , Bekaii-Saab Tanios S. , Stauffer John , Starr Jason S.
Published: August 2023

PURPOSE

Pancreatic cancer (PC) carries a poor prognosis with high rates of unresectable/metastatic disease at diagnosis, recurrence after resection, and few systemic therapy options. Deficient mismatch repair (dMMR)/high microsatellite instability (MSI-H) PCs demonstrated uncharacteristically poor outcomes in KEYNOTE-158, evaluating pembrolizumab in MSI-H solid tumors. Our study aggregates the Mayo Clinic experience with dMMR/MSI-H PCs, characterizing the clinical, molecular, and treatment response patterns with a focus on response to immune checkpoint inhibitors (ICIs).

METHODS

Retrospective data were collected from the electronic medical record from December 2009 to February 2023. Patients were included if they had a pathologically confirmed pancreatic malignancy and had (1) deficient expression of mismatch repair (MMR) proteins by tumor immunohistochemistry, (2) pathogenic mutation of MMR genes on genomic sequencing, and/or (3) MSI-H by polymerase chain reaction.

RESULTS

Thirty-two patients were identified for inclusion, with all stages of disease represented. Sixteen of these patients underwent surgery or chemoradiotherapy. Of these patients, uncharacteristically favorable responses were seen, with a recurrence rate of only 19% (n = 3) despite a median follow-up of 25 months. In the palliative setting, excellent responses to ICI were seen, with overall response rate (ORR) of 75% (20% complete response). Median time to disease progression was not reached. Response rates to cytotoxic chemotherapy in the palliative setting were poor, with 30% ORR and median time to progression of 4 months. We observed a high rate of discrepancy between MMR and MSI testing methods, representing 19% of the entire cohort and 26% of evaluable cases.

CONCLUSION

Our data argue for the preferential use of ICI over cytotoxic chemotherapy in any patient with dMMR/MSI-H PC requiring systemic therapy, including in the metastatic and adjuvant/neoadjuvant settings.
The upper temperature and hypoxia limits of Atlantic salmon (Salmo salar) depend greatly on the method utilized
Authors: Sandrelli Rebeccah M. , Gamperl A. Kurt
Published: August 2023

In this study, Atlantic salmon were: (i) implanted with heart rate (fH) data storage tags (DSTs), pharmacologically stimulated to maximum fH, and warmed at 10°C h−1 (i.e. tested using a ‘rapid screening protocol’); (ii) fitted with Doppler® flow probes, recovered in respirometers and given a critical thermal maximum (CTmax) test at 2°C h−1; and (iii) implanted with fH DSTs, recovered in a tank with conspecifics for 4 weeks, and had their CTmax determined at 2°C h−1. Fish in respirometers and those free-swimming were also exposed to a stepwise decrease in water oxygen level (100% to 30% air saturation) to determine the oxygen level at which bradycardia occurred. Resting fH was much lower in free-swimming fish than in those in respirometers (∼49 versus 69 beats min−1) and this was reflected in their scope for fH (∼104 versus 71 beats min−1) and CTmax (27.7 versus 25.9°C). Further, the Arrhenius breakpoint temperature and temperature at peak fH for free-swimming fish were considerably greater than for those tested in the respirometers and given a rapid screening protocol (18.4, 18.1 and 14.6°C; and 26.5, 23.2 and 20.2°C, respectively). Finally, the oxygen level at which bradycardia occurred was significantly higher in free-swimming salmon than in those in respirometers (∼62% versus 53% air saturation). These results: highlight the limitations of some lab-based methods of determining fH parameters and thermal tolerance in fishes; and suggest that scope for fH may be a more reliable and predictive measure of a fish's upper thermal tolerance than their peak fH.
Factors Influencing Implementation of Youth Physical Activity Interventions: An Expert Perspective
Authors: Lau Erica Y. , Wandersman Abraham H. , Pate Russell R.
Published: August 2023

Little is known about the factors that influence implementation of physical activity interventions undertaken in youth-serving settings, and this lack of information impedes the development of effective implementation strategies. This study convened a panel of experts to identify factors that are most important in achieving successful implementation of physical activity interventions in youth-serving organizations. Five recognized experts participated in a four-round, modified Delphi consensus process. The panelists were asked to achieve consensus on a list of potential factors that are most important in predicting successful implementation and on the descriptions of these factors. They also provided estimates regarding the individual contributions each of the identified factors make in predicting a successful implementation. These estimates were then translated into Bayesian predictive models for factor selection. The expert panel achieved consensus on 23 factors. Results from the factor selection procedures indicated that a final model containing 15 factors yielded the greatest contributions in predicting successful implementation of youth physical activity interventions. In this final model, five factors were classified as organizational characteristics, six factors as implementation processes, two factors as provider characteristics, and two factors as program characteristics and community-level factors, respectively. In conclusion, this is the first study to identify factors that are important in achieving a successful implementation of youth physical activity interventions through systemically gathering information from a panel of experts. The 15 factors identified in this study provide important information to inform implementation planning and evaluation of future interventions.
Clinical Research to Community Practice
Authors: Donnelly Joseph E.
Published: August 2023

In April 2016, the American College of Sports Medicine launched a new journal, the Translational Journal of the American College of Sports Medicine. Translational research is difficult to define and means different things to different individuals. It is a bit analogous to the phrase “I can't define it but I know it when I see it.” However, the essence of translational science is the attempt to apply basic and clinical science findings to communities and populations. That is, take what is known and apply it to the real world.
Translational Gap between Laboratory and Playing Field: New Era to Solve Old Problems in Sports Science
Authors: Eisenmann Joey
Published: August 2023

“Bridging the gap” and “science into practice” have long been themes in high-performance sports training, conditioning, and monitoring. Recently, parallel developments in sports science and translational science in the United States have perhaps set the stage for a new era to solve old problems. This article will discuss the trends in sports science in the United States, provide an overview of translational science and knowledge management, summarize and align existing translational science research models, address problems and potential solutions in the translational sports science framework, and provide examples of research that have translated sports science research into practice. The objectives of this article are to stimulate collaborations between academics and practitioners and to provide solutions for harmonizing integrated sports performance models.
Menstrual Dysfunction in Females Presenting to a Pediatric Sports Medicine Practice
Authors: Fischer Anastasia N. , Yang Jingzhen , Singichetti Bhavna , Young Julie A.
Published: August 2023

This study aimed to determine the prevalence of menstrual dysfunction (MD) among injured female athletes presenting to a pediatric primary care sports medicine clinic and to examine the influence of type of injury (acute or overuse) and type of sports participation (i.e., lean build sports [LBS], non–lean build sports [NLBS], or combination [CBS]) on the likelihood of experiencing MD to recommend better screening practices for these athletes. Demographics and menstrual history were collected from females (10–18 yr) presenting with a new musculoskeletal injury, along with type of injury and participation in LBS (n = 156), NLBS (n = 243), or CBS (n = 92). Logistic regression models were used to determine the odds of MD, adjusting for age and body mass index. Of 491 females who met inclusion criteria for the study, 15.9% reported MD. Females experiencing MD were likely to be older at menarche (12.3 vs 11.9, P = 0.006), with a similar body mass index (P = 0.244). Female athletes experiencing an acute or overuse injury had a similar risk of experiencing MD (adjusted odds ratio [AOR] = 1.40, 95% CI = 0.85–2.28). Females who participated in LBS were as likely as those who participated in NLBS to have MD (AOR = 1.52, 95% CI = 0.86–2.66). However, participation in NLBS or CBS tended to protect injured females from MD as compared with sole LBS participation (AOR = 0.77, 95% CI = 0.46–1.29), although the relationship was not statistically significant. MD is prevalent in adolescent female athletes presenting with musculoskeletal injuries; however, it is not associated with the type of injury or type of sport in which the athlete participates. All adolescent females presenting with musculoskeletal injury should be screened for MD.
Development of a Logic Model for a Community-Based Walking Program for Mothers
Authors: Das Bhibha M. , Dlugonski Deirdre
Published: August 2023

Despite the evidence demonstrating the importance of physical activity, approximately 50% of US women meet aerobic national physical activity guidelines. There is often a disconnect between successful evidence-based physical activity programs and the translation/dissemination of these programs into community settings; this might be overcome through use of program theory and evaluation. The purpose of this study was to discuss the development of a logic model for a community-based walking program for mothers by providing background on the population and describing program theory, the process of developing the logic model, and logic model components. Participants (N = 86) were mothers (18–64 yr) with a child 26 yr or younger living in her household. Process evaluations, observational, and focus group data were used in a content analysis to determine major themes, informing the logic model. Findings revealed a set of resources needed to complete program activities. These activities led to short- and long-term outcomes. The overarching goal of the program is to improve the overall health status of families and communities. This logic model may have significant public health effect because it can serve as a framework for other communities wanting to develop, implement, and evaluate a walking program for mothers. To the authors' knowledge, this logic model is the first of its kind and may be used by public health practitioners and communities to promote physical activity, specifically walking, in an underserved population.
Validity of Activity Tracker Step Counts during Walking, Running, and Activities of Daily Living
Authors: Toth Lindsay P. , Park Susan , Pittman Whitney L. , Sarisaltik Damla , Hibbing Paul R. , Morton Alvin L. , Springer Cary M. , Crouter Scott E. , Bassett David R.
Published: August 2023

The popularity of activity trackers has grown in recent years, and health-conscious consumers are interested in using them for personal motivation and goal setting. Although these devices can estimate several variables, steps are the simplest and easiest to understand. Therefore, the purpose of this study was to investigate the validity of activity tracker step counts during treadmill locomotion (walking and running on a treadmill), overground walking (walking in a hallway), and activities of daily living (ADL). Twenty-one adults (mean ± SD, 26 ± 9 yr) wore six consumer-grade devices (Garmin Vivofit 2, Fitbit Charge, Withings Pulse Ox, Yamax Digi-Walker SW-200, Fitbit Zip, and Omron HJ-322U) and four research-grade devices (two ActiGraph WGT3X-BT [AG] and two StepWatch [SW]). They performed 15 activities for 2 min each, separated by a 1-min rest. Hand-counted (HC) steps served as the criterion measure. Agreement between devices and HC was assessed with 95% equivalence testing. This was done within each category and for all categories combined. For treadmill trials, the SW-modified was significantly equivalent to the criterion, estimating 104.7% of HC steps. For overground walking trials, Fitbit Zip, Yamax Digi-Walker SW-200, and both SW devices were significantly equivalent to the criterion, estimating 98.2% to 102.2% of HS steps. For ADL, the AG-hip (low-frequency extension) was statistically equivalent to the criterion. For all activities combined, the SW-modified (99.5% of HC steps) and AG-hip (low-frequency extension; 94.4% of HC steps) were equivalent to the criterion. In conclusion, a research-grade device (SW) had the greatest accuracy for step counts, making it suitable for clinical research applications. Consumer-grade trackers performed better than expected, and the step count error (10%–15%) may be acceptable for those wanting to track behavior change.
Development of a Community Wellness Program for Prostate Cancer Survivors
Authors: Culos-Reed Nicole , Dew Michael , Zahavich Ashley , Wilson Kate , Arnason Tyla , Mackenzie Michael , Brissette Christy , Van Patten Cheri , Santa Mina Daniel
Published: August 2023

Men living with prostate cancer benefit from multidisciplinary wellness programs that include physical activity, nutrition, and stress reduction. Such programs have been shown to decrease treatment-related side effects and reduce the risk of cancer recurrence and other comorbidities associated with prostate cancer, while also improving overall fitness, health, and quality of life. Despite these benefits, access to wellness programs and educational resources for men with prostate cancer are limited in Canada. This study aimed to describe the development of the TrueNTH Lifestyle Management program, an initiative aimed at establishing evidence-based wellness programs in the community to improve access to trained professionals and educational resources specific to the prostate cancer population. Protocol for an integrated, community-based 12-wk intervention of group exercise, yoga, and nutrition education sessions was developed based on evidence and insights from existing cancer-specific programs. Evidence-based tools, resources, and training were developed to support program facilitation and standardize intervention delivery. Pilot testing using the RE-AIM framework was conducted at three distinct community-based sites with demographics, physical fitness, and quality-of-life outcomes collected at baseline and 12 wk. Fifty-eight participants enrolled, with 32 completing quality-of-life measures and 39 completing fitness measures before and after the 12-wk intervention. Significant improvements were seen in the physical measures of body composition, flexibility, dynamic balance, muscular endurance, and functional aerobic endurance as well as weekly moderate and strenuous physical activity levels (all P’s < 0.05). TrueNTH Lifestyle Management provides evidence-based professional training and survivorship resources necessary for the potential implementation of a safe, effective, and beneficial community wellness program for men living with prostate cancer.
Imunidade tributária - Lista telefônica - Publicidade
Authors: Sanches Sydney
Published: August 2023

Supremo Tribunal Federal
Mandado de injunção - Requisitos - Legitimidade ativa
Authors: Ribeiro Antônio de Pádua
Published: August 2023

Superior Tribunal de Justiça
Empresa pública - Servidor - Período eleitoral
Authors: Sussekind Arnaldo
Published: August 2023

.
Controle jurisdicional - Competência - Entidades públicas
Authors: Velloso Carlos Mário
Published: August 2023

Tribunal Federal de Recursos
Licitação - Inidoneidade - Direito de defesa
Authors: Silva Jorge Araken Faria da
Published: August 2023

Tribunal de Justiça do Território do Acre
Funcionário público - Reclassificação - Proventos
Authors: Branco Francisco de Salles Mourão
Published: August 2023

Tribunal de Contas da União
Funcionário público - Aposentadoria - Tempo de serviço
Authors: Ramalhete Clóvis
Published: August 2023

Presidência da República
Concorrência - Sociedade de economia mista - Supervisão ministerial
Authors: Ramalhete Clóvis
Published: August 2023

Presidência da República
Concorrência - Sociedade de economia mista - Princípio da igualdade
Authors: Tácito Caio
Published: August 2023

- E lícito estabelecer, no edital, a exploração de ramo específico de comércio em lojas de domínio do município.- Não constitui monopólio a exclusividade na exploração de determinado ramo de comércio em lojas de estação rodoviária.
Tribunal de Contas - Assembléia legislativa - Silêncio
Authors: Tácito Caio
Published: August 2023

- E inconstitucional o art. 91, n.O III da Constituição de São Paulo, que, em desacordo com o paradigma federal obrigatório, atribui ao silêncio de Assembléia Legislativa o efeito de aprovar a impugnação do Tribunal de Contas ao registro do contrato.
Bem público - Desafetação - Doação
Authors: Gasparini Diogenes
Published: August 2023

- E válida a lei que, desaletando bem de uso comum e transferido o imóvel para a categoria de bem patrimonial, a seguir o destina, mediante doação, à construção de praça de esportes.
Sanções tributárias
Authors: Guimarães Carlos da Rocha
Published: August 2023

1. Conceito de sanção em geral. Sentido etimológico. Sanção no direito arcaico: tabu, sacer esto. O ser do direito. O direito como decorrência do ser do homem. Disposição normativa e sanção. Análise lógica da norma. Figuras de sanção. Sanção, castigo, execução. Sanção no direito tributário. As disposições do Código Tributário Nacional. Obrigação principal e acessória. Conversão da pena pecuniária em obrigação principal. Figuras de sanções tributárias. Competência para estabelecer sanções. Sanções criminais. Crime de sonegação.
Taxa - Fato gerador - Poder de polícia
Authors: Mayer Rafael
Published: August 2023

Supremo Tribunal Federal
Taxa - Fato gerador - Poder de polícia
Authors: Miranda Decio
Published: August 2023

Supremo Tribunal Federal
Constituição Estadual - Inconstitucionalidade - Representação
Authors: Alves Moreira
Published: August 2023

Supremo Tribunal Federal
Desapropriação - Interesse social - Distrito Industrial
Authors: Miranda Decio
Published: August 2023

Supremo Tribunal Federal
Ação direta de inconstitucionalidade - medida cautelar - Suspensão provisória
Authors: Falcão Djaci
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Gratificação - Licença especial
Authors: Velloso Carlos Mário
Published: August 2023

Tribunal Federal de Recursos
Funcionário público - Acumulação de cargos - Médico
Authors: Ribeiro Justino
Published: August 2023

Tribunal Federal de Recursos
Funcionário público - Pensão especial - Previdência social
Authors: Velloso Carlos Mário
Published: August 2023

Tribunal Federal de Recursos
Código Brasileiro de Futebol - Justiça desportiva - Recurso
Authors: Leitão Lauro
Published: August 2023

Tribunal Federal de Recursos
Desapropriação - Fundo de comércio - Correção monetária
Authors: Rollemberg Armando
Published: August 2023

Tribunal Federal de Recursos
Diploma estrangeiro - Reavaliação - Convênio cultural
Authors: Leite Evandro Guedes
Published: August 2023

Tribunal Federal de Recursos
Funcionário público - Aposentadoria - Tempo de serviço
Authors: Affonso Sebastião Baptista
Published: August 2023

Tribunal de Contas da União
Imposto único - Isenção - Instituição social
Authors: Mathias Murillo Forjaz
Published: August 2023

Ministério da Fazenda
Empresa pública - Publicidade - Comissões
Authors: Pequeno Marcial Dias
Published: August 2023

Governo do Estado do Rio de Janeiro
Fundação intermunicipal - Natureza jurídica - Regime primário
Authors: Tácito Caio
Published: August 2023

Conselho Federal de Educação
Leis, Decretos-Lei e Decretos (1979)
Authors: Desconhecido Autor
Published: August 2023

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A proteção jurídica dos interesses coletivos
Authors: Moreira José Carlos Barbosa
Published: August 2023

Conceito dos interesses coletivos. Direito comparado. Proteção judicial.Legitimação para agir. Natureza da tutela judicial. Atos do poder público e atos de particulares. Limites da ação judicial.
Reajustamento e recomposição de preços em contrato administrativo
Authors: Meirelles Hely Lopes
Published: August 2023

1. Considerações preliminares. 2. Equação econômico-financeira. 3.Reajustamento contratual de preços. 4. Recomposição de preços.5. Conclusões.
Taxa - Poder de polícia - Autonomia municipal
Authors: Guerra Cordeiro
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Cessão - Justiça do Trabalho
Authors: Miranda Decio
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Tempo de serviço - Vantagem
Authors: Munoz Soares
Published: August 2023

Supremo Tribunal Federal
Professor - Vitaliciedade - Liberdade de Cátedra
Authors: Mayer Rafael
Published: August 2023

Supremo Tribunal Federal
Polícia militar - Gratificação - Inativos
Authors: Peixoto Cunha
Published: August 2023

Supremo Tribunal Federal
Desapropriação - Distrito industrial - Doação
Authors: Falcão Djaci
Published: August 2023

Supremo Tribunal Federal
Mandado de segurança - Lei em tese - Salário mínimo
Authors: Alves Moreira
Published: August 2023

Supremo Tribunal Federal
Conselho de Engenharia - Poder regulamentar - Limites
Authors: Patterson William
Published: August 2023

Tribunal Federal de Recursos
Responsabilidade civil - Arrendamento - Indenização
Authors: Brito Washington Bolivar de
Published: August 2023

Tribunal Federal de Recursos
Terceiro Regime Jurídico
Authors: Motta Carlos Pinto Coelho
Published: August 2023

1. Autarquia estadual e servidores recibados. 2. A explicitação do terceiro regime jurídico. 3. Conclusões.
Funcionário público - Vencimentos - Majoração
Authors: Peixoto Cunha
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Dupla aposentadoria - Previdência social
Authors: Rocha Otto
Published: August 2023

Tribunal Federal de Recursos
Anistia - Retorno - Direito subjetivo
Authors: Paz Firmino
Published: August 2023

Supremo Tribunal Federal
Representação - Lei revogada - Inconstitucionalidade
Authors: Alves Moreira
Published: August 2023

Supremo Tribunal Federal
Imposto de renda - Aumento de capital - Integralização
Authors: Rollemberg Armando
Published: August 2023

Tribunal Federal de Recursos
Lei estadual - Dispensa de concurso - Inconstitucionalidade
Authors: Mayer Rafael
Published: August 2023

Supremo Tribunal Federal
Vereador - Perda de mandato - Pena acessória
Authors: Paz Firmino
Published: August 2023

Supremo Tribunal Federal
Poder de polícia - Moral pública - Absolvição criminal
Authors: Madeira Carlos
Published: August 2023

Tribunal Federal de Recursos
Aplicações financeiras - Cadernetas de poupança - ORTN
Authors: Luz Ivan
Published: August 2023

Tribunal de Contas da União
Empresa nacional - Acionista estrangeiro - Concorrência
Authors: Meirelles Hely Lopes
Published: August 2023

- Considera-se empresa nacional a sociedade organizada segundoa lei brasileira, com sede efetiva no País.- A Administração não pode distinguir as empresas nacionaisem razão do local de residência ou domicílio de seus acionistas majoritários.- Nas concorrências, o edital não pode estabelecer fator de julgamento,de desempate ou de preferência baseado em condições pessoaisdos participantes.- O proponente prejudicado por discriminação ilegal do editalou do julgamento pode invalidá-los judicialmente por mandado desegurança ou ação ordinária anulat6ria.
Subsídio - Redução discricionária - Bis in idem
Authors: Falcão Djaci
Published: August 2023

Supremo Tribunal Federal
Delegação administrativa - Danos - Responsabilidade
Authors: Velloso Carlos Mário
Published: August 2023

Tribunal Federal de Recursos
Encampação - Indenização - Tombamento
Authors: Velloso Carlos Mário
Published: August 2023

Tribunal Federal de Recursos
Educação pré-escolar - Idade mínima - Norma estadual
Authors: Alves Moreira
Published: August 2023

Supremo Tribunal Federal
Mandado de segurança - Universidade estadual - Competência
Authors: Alves Moreira
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Professor titular - Concurso
Authors: Aragão Newton Mendes de
Published: August 2023

Departamento Administrativo do Serviço Público
Imposto - Acréscimo - Sanção administrativa
Authors: Albuquerque Xavier de
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Aposentadoria - Vinculação
Authors: Alves Moreira
Published: August 2023

Supremo Tribunal Federal
Bem público - Rio estadual - Domínio
Authors: Cataldo Paulo Cesar
Published: August 2023

Presidência da República
Dívida fiscal - Correção monetária - Termo inicial
Authors: Passarinho Aldir
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Remoção - Motivo
Authors: Acioli Pedro da Rocha
Published: August 2023

Tribunal Federal de Recursos
Crime contra segurança nacional - Presidente da República - Injúria
Authors: Silveira Néri da
Published: August 2023

Supremo Tribunal Federal
Ato administrativo - Controle judicial - Renúncia
Authors: Munoz Soares
Published: August 2023

Supremo Tribunal Federal
Responsabilidade do estado - Dever de vigilância - Pedágio
Authors: Leite Evandro Gueiros
Published: August 2023

Tribunal Federal de Recursos
Empresas estatais - 13º salário - Correção monetária
Authors: Branco Francisco de Salles Mourão
Published: August 2023

Tribunal de Contas da União
Bem público - Cessão pública - Benfeitorias
Authors: Branco Francisco de Salles Mourão
Published: August 2023

Tribunal de Contas da União
Hipoteca de Terreno da Marinha em favor de empresa estrangeira - - Validade e efeitos jurídicos - Procedimento arbitral
Authors: Wald Arnoldo
Published: August 2023

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Registro - Silêncio da administração - Direito de defesa
Authors: Madeira Carlos
Published: August 2023

Tribunal Federal de Recursos
Isenção - Entidade filantrópica - Utilidade pública federal
Authors: Mayer Rafael
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Aposentadoria - Correção monetária
Authors: Passarinho Aldir
Published: August 2023

Supremo Tribunal Federal
Administração pública - Serviço contratado - Relação de emprego
Authors: Leite Evandro Gueiros
Published: August 2023

Tribunal Federal de Recursos
Funcionário público - Diárias - Órgão de deliberação coletiva
Authors: Aragão Newton Mendes de
Published: August 2023

Departamento Administrativo do Serviço Público
Presidente da República - Pensão especial - Doença profissional
Authors: Branco Francisco de Salles Mourão
Published: August 2023

Tribunal de contas da União
Código eleitoral e justiça eleitoral
Authors: Muñoz Pedro Soares
Published: August 2023

1. O advento do Código Eleitoral e da Justiça Eleitoral. 2. O CódigoEleitoral em vigor, seu conteúdo e sistema. J. Estrutura e atribuiçõesda Justiça Eleitoral. 4. O eleitorado brasileiro. 5. Alistamento eleitoral.6. Apuração das eleições. 7. Abstenção eleitoral. 8. Transportee fornecimento de refeições para os eleitores. 9. Eleição para presidentee vice-presidente da República. 10. O voto distrital e a adoçãode processamento eletrônico de dados nos serviços eleitorais. 11. Conclusão.
Contribuição para o Finsocial - Decreto-lei - Princípio de anualidade
Authors: Madeira Carlos
Published: August 2023

Trbunal Federal de Recursos
Empresa estatal - Lucro inflacionário - Decisão judicial
Authors: Luz Ivan
Published: August 2023

Tribunal de Contas da União
Desapropriação de ações
Authors: Meirelles Hely Lopes
Published: August 2023

- No nosso direito é legítima a desapropriaçi:.o de ações desociedade anônima.- Só é admissível a desistência da ação expropriatória, desdeque o expropriante devolva o mesmo bem expropriado e nas mesmascondições e estado em que o recebeu.
Funcionário público - Ato disciplinar - Controle judicial
Authors: Falcão Djaci
Published: August 2023

Supremo Tribunal Federal
Cargo público - Autorização legislativa - Separação de poderes
Authors: Muñoz Pedro Soares
Published: August 2023

Supremo Tribunal Federal
Mandado de segurança - Ato normativo - Reajuste de prestações
Authors: Passarinho Aldir
Published: August 2023

Supremo Tribunal Federal
Desapropriação - Caducidade - Retrocessão
Authors: Acioli Pedro da Rocha
Published: August 2023

Tribunal Federal de Recursos
Direitos autorais - Sonorização ambiental - Lucro
Authors: Cataldo Paulo Cesar
Published: August 2023

Presidência da República
Funcionário público - Plano de classificação - Enquadramento
Authors: Mayer Rafael
Published: August 2023

Supremo Tribunal Federal
Ato administrativo - Mandado de segurança - Decadência
Authors: Silveira Néri da
Published: August 2023

Supremo Tribunal Federal
Emenda Constitucional - Iniciativa - Remuneração
Authors: Buzaid Alfredo
Published: August 2023

Supremo Tribunal Federal
Concurso - Professor titular - Eficácia no tempo
Authors: Cataldo Paulo Cesar
Published: August 2023

Presidência da República
Intervenção em serviço de ônibus
Authors: Tácito Caio
Published: August 2023

1. Fundamentos do ato de intervenção. 2. Natureza jurídica dos contratosde transporte coletivo: concessão e subconcessão. 3. Intervençãono serviço e intervenção na empresa. 4. Gratuidade no transporte.5. Equilíbrio financeiro no contrato.
Do direito individual ao direito difuso
Authors: Tácito Caio
Published: August 2023

1. As sementes da liberdade. 2. Declarações de direitos: limitações aoabsolutismo. 3. Direitos individuais. 4. Consagração dos direitos sociaisdo homem. 5. Ordem jurídica internacional. 6. Direitos difusos:conceito e proteção. 7. Legitimação para agir. 8. Sanções.
Imposto - Inconstitucionalidade - Retroatividade
Authors: Reis Sebastião Alves dos
Published: August 2023

Tribunal Federal de Recursos
Funcionário público - Acumulação - Estabilidade
Authors: Silveira Néri da
Published: August 2023

Supremo Tribunal Federal
Desapropriação - Indenização - Matas
Authors: Rezek Francisco
Published: August 2023

Supremo Tribunal Federal
Confisco - Correção monetária - Prestação de contas
Authors: Branco Francisco de Salles Mourão
Published: August 2023

Tribunal de Contas da União
Taxa - Preço público - Poder de polícia
Authors: Acioli Pedro da Rocha
Published: August 2023

Tribunal Federal de Recursos
Tribunal de Justiça - Cargo de direção - Provimento
Authors: Silveira Néri da
Published: August 2023

Supremo Tribunal Federal
Empresa pública - Previdência social - Banco Nacional da Habitação
Authors: Poletti Ronaldo Rebello de Britto
Published: August 2023

Presidência da República
Magistrado - Lei orgânica - Remoção
Authors: Buzaid Alfredo
Published: August 2023

Supremo Tribunal Federal
Magistrado - Previdência social - Contribuição
Authors: Miranda Decio
Published: August 2023

Supremo Tribunal Federal
Ato administrativo - Competência - Motivação
Authors: Miranda Carlos
Published: August 2023

Tribunal Federal de Recursos
Funcionário público - Aposentadoria - Cargo em comissão
Authors: Poletti Ronaldo Rebello de Britto
Published: August 2023

Presidência da República
Bem público federal - Servidão - Via pública municipal
Authors: Tácito Caio
Published: August 2023

- Não pode o mumclplo apropriar-se de área de domínio daUnião, quer pela via· direta da desapropriação, quer pela via indiretoda ocupação, para convertê-la em estrada municipal.
Tarifa de lixo - Inconstitucionalidade - Repetição do indébito
Authors: Corrêa Oscar
Published: August 2023

Supremo Tribunal Federal
Funcionário público - Peculato - Estado de necessidade
Authors: Cândido José
Published: August 2023

Tribunal Federal de Recursos
Ministério Público - Vencimento - Reajuste
Authors: Passarinho Aldir
Published: August 2023

Supremo Tribunal Federal
Mandado de segurança - Competência - Justiça Federal
Authors: Pinheiro Helio
Published: August 2023

Tribunal Federal de Recursos
Crime contra honra - Televisão - Responsabilidade do entrevistado
Authors: Corrêa Oscar
Published: August 2023

Supremo Tribunal Federal
Distrito Federal - Governador - Nomeação interina
Authors: Bessone Darcy
Published: August 2023

Presidência da República
Itaipu - Bem público - Doação
Authors: Bessone Darcy
Published: August 2023

Presidência da República
Contrato administrativo - Ferrovia estadual - Convênio
Authors: Bessone Darcy
Published: August 2023

Presidência da República
Convênio - Ratificação - Câmara Municipal
Authors: Alves Moreira
Published: August 2023

Supremo Tribunal Federal
Mandado de segurança - Ato judicial - Turma
Authors: Buzaid Alfredo
Published: August 2023

Supremo Tribunal Federal
Licitação - Edital - Poder discricionário
Authors: Madeira Carlos
Published: August 2023

Tribunal Federal de Recursos
Funcionário público - Nomeação - Concurso
Authors: Alves Moreira
Published: August 2023

Supremo Tribunal Federal
Período eleitoral - Nomeação - Ato nulo
Authors: Passarinho Aldir
Published: August 2023

Supremo Tribunal Federal
Competência legislativa - Energia nuclear - Monopólio da União
Authors: Falcão Djaci
Published: August 2023

Supremo Tribunal Federal