bluuebunny/crossref_metadata_2025 huggingface dataset:
Releituras, paródia e intertextualidade em Braz, Quincas & Cia (2002), de Antonio Fernando Borges
Authors: Camargo Flávio Pereira
Published: October 2016

Neste ensaio, temos como objetivo analisar os procedimentos e as estratégias narrativas utilizadas por Antonio Fernando Borges em Braz, Quincas & Cia (2002) em suas releituras da obra de Machado de Assis, por meio da intertextualidade, principalmente através da paródia como estratégia para o autoquestionamento estético, e as suas implicações tanto para a construção da narrativa quanto para sua recepção por parte do leitor.
A alegria em Tutameia: terceiras estórias de Guimarães Rosa
Authors: Bueno Giselle
Published: October 2016

Este artigo tem como objeto a alegria em Tutameia: terceiras estórias. É a simpatia de João Guimarães Rosa por ela que também está em causa nas reflexões tão fundamentais sobre o humor do primeiro prefácio, “Aletria e hermenêutica”. O humor pode ser pensado como meio de influir a alegria tutameica e, simultaneamente, como uma das formas em que ela se manifesta. Sob o viés do autor mineiro, a alegria é fruto de certa hermenêutica, de um exercício de interpretação da realidade, compreendida, por sua vez, como visceralmente contraditória. Em eterna invenção no interior do sujeito, a alegria é empreendimento, risco, proeza. Angústia-que-ri, dá sinal de si sempre a partir de uma profunda consciência do absurdo.
Os espaços de recepção transnacional dos filmes: propostas para uma abordagem semiopragmática
Authors: Bamba Mahomed
Published: October 2016

Quais são as determinações contextuais e institucionais que intervêm na recepção transnacional dos filmes? Seguindo uma linha de reflexão que se situa entre as abordagens geopolítica e semiopragmática do cinema contemporâneo, tecemos algumas considerações teóricas e metodológicas sobre os modos de leitura e interpretação do world cinema nos espaços acadêmicos. Revisamos as principais concepções teóricas sobre o fenômeno de “transnacionalidade” cinematográfica. Examinamos a lógica de formação de comunidades de interpretação, os sistemas de valores e os horizontes de expectativas no conjunto heteróclito definido por Elsaesser e Hagener (2010) como “comunidade transnacional de ideias”. Partimos dessa categoria (geográfica e, ao mesmo tempo, teórica) para repensar os estudos do world cinema como um campo de microespaços de comunicação, de recepção e de leitura fílmica (ODIN, 2011). É nessa reconstrução teórica que reavaliamos, por fim, a problemática dos (in)variantes no processo de negociação dos sentidos dos filmes contemporâneos africanos no “espaço discursivo” universitário.
O hibridismo genealógico: O cego de Joaquim Manuel de Macedo
Authors: Botton Fernanda Verdasca
Published: October 2016

Na tragédia grega, a figura do cego é comumente ligada à sabedoria e à agudeza de sentidos. Na peça teatral O cego, de Joaquim Manuel de Macedo, entretanto, a ausência da visão física reúne em Paulo o subjetivismo romântico e o inexorável destino dos heróis trágicos. Além disso, no desenrolar da ação, a cegueira de Paulo trará aos demais personagens da trama outros princípios ligados ao drama e à tragédia clássica. Sendo assim, analisando os elementos constitutivos de O cego, o presente artigo visa revelar o hibridismo genealógico presente na construção deste texto dramatúrgico de Macedo.
Notas sobre uma literatura vulnerável: El artista sanitário
Authors: Santos Antonio Carlos
Published: October 2016

As narrativas de Carlos Ríos nos remetem a uma situação contemporânea que aponta para um esgotamento do paradigma modernista. O objetivo deste texto, é pensar as estratégias de Carlos Ríos, pensar como rearma o sensível de modo a desvelar uma nova noção de comunidade: como habitar o mundo? Como se relacionar com os animais? Como escrever um relato?
O Édipo Romântico, da literatura ao cinema
Authors: Calaça Fausto , Reis Célia Maria Domingues da Rocha
Published: October 2016

No presente artigo, realizamos uma análise comparada entre o romance de Honoré de Balzac, O lírio do vale (1836) e o filme de François Truffaut, Beijos proibidos (1968), tendo como perspectiva os temas desencantamento, nostalgia, romance de aprendizagem, Nouvelle vague e a noção de “Édipo romântico”, elaborada por Pierre Laforgue (2002). Colocamos em destaque o drama de Antoine Doinel, protagonista do filme, que re-apresenta um episódio semelhante ao da trajetória do jovem protagonista Félix de Vandenesse, do romance de Balzac.
A NUDEZ DO SOM E DA FACE: O PORNÔ VANGUARDA DE BEAUTIFUL AGONY
Authors: Nunes Oliveira Selma , Da Silva Alves Guilherme Di Angellis
Published: October 2016

O artigo propõe uma discussão acerca da série de vídeos eróticos/pornôs Beautiful Agony (www.beautifulagony.com), que exibe headshots de homens e mulheres se masturbando. Ao comparar a estrutura narrativa da série com a obra de vanguarda Blowjob, de Andy Warhol, a pesquisa observa a presença de elementos eróticos e artísticos diluídos no pornográfico, tornando limitadoras definições fixas dos conceitos e dos conteúdos. Em Beautiful Agony, o som e as expressões faciais cumprem aquilo que Linda Williams chama de princípio de máxima visibilidade, elemento constitutivo da pornografia. É vanguardista por propor uma erótica que distende noções e práticas comuns ao gênero, com conteúdo amador e estética e enquadramento conceituais, em uma proposta mais intimista que performática.
SAMUEL BECKETT E A DESISTÊNCIA DIANTE DO TEMPO
Authors: Kalil Auad Pedro Henrique Trindade
Published: October 2016

Este artigo é uma reflexão sobre o tempo, o teatro e o tempo do/no teatro, se apoiando na obra de Samuel Beckett, mais particularmente de seu texto A Última Gravação. Para tal análise, articularei o tempo da peça do autor irlandês com o conceito imagem-tempo do filósofo francês Gilles Deleuze. Nesse sentido, espera-se esmiuçar o texto de Beckett, seus métodos e história, para provocar uma reflexão incisiva sobre o tempo no teatro e a relação particular do sujeito com o tempo
Lifestyle entrepreneurs, hostels and backpacker tourism development: the case of San Cristóbal de las Casas, Mexico
Authors: Brenner Ludger , Fricke Jörn
Published: October 2016

Drawing on the analytical framework of lifestyle entrepreneurs, this paper analyzes their motivation, objectives and business strategies in relation to the management of "hostels" in an effort to shed light on key agents of (scarcely investigated) backpacker-driven tourism development at San Cristóbal de las Casas. Based on in-depth interviews with owners and managers, we conclude that lifestyle entrepreneurs strive to meet the demands of contemporary backpackers by providing a specific ambience and outpacing more profit-oriented competitors. In addition, business owners work to sustain an explicitly hedonistic way of life to perpetuate their status as “senior” backpackers who offer customized, hard-to-imitate services. However, lifestyle entrepreneurs have also developed strategies to cope with increasing competition and recent demand-related trends.
Redes sociales: Herramienta de Marketing Internacional en el sector hotelero
Authors: Miranda Zavala Ana María , Cruz Estrada Isaac
Published: October 2016

El presente artículo tiene como objetivo identificar las estrategias de marketing internacional en redes sociales que realizan los hoteles de cuatro y cinco estrellas de la ciudad de Tijuana, Baja California, México. Asimismo, la revisión de las características y contenidos de las redes sociales de este sector, reconociendo la importancia en el marketing internacional como medio de comunicación con los clientes. De este modo, se propone caracterizar los atributos que consideran esenciales los clientes de los hoteles y que hacen que el visitante incremente su confianza en la utilización de dichos medios. La investigación ha contemplado un análisis cualitativo de las redes sociales de 16 hoteles de cuatro y cinco estrellas de la ciudad de Tijuana, Baja, California, registrados en la Secretaría de Turismo (SECTUR) y la Asociación de Hoteles del Noroeste (ASHONO) para identificar la manera en que llevan a cabo su estrategia de marketing a través de esos medios. Asimismo, se aplicaron encuestas a 267 clientes de los hoteles con la finalidad de caracterizar los atributos que consideran importantes que aparezcan en la red social del hotel, que habrían de incrementar la eficiencia de los resultados de la estrategia de marketing con redes sociales.
THE EXPRESSION AND PURIFICATION OF OCTA-ARGININE APOPTIN AND ITS ABILITY TO KILL CANCER CELLS
Authors: Sahlan Muhamad , Bela Budiman , Bowolaksono Anom , Malik Amarila , Yohda Masafumi
Published: October 2016

Objective: In this research, chicken anemia virus apoptin optimized genetically for expression in Escherichia coli and also modified using (His)6 tag, (Arg)8 tag, and HlyA tag intended for purification needs, penetration enhancement, and secretion from bacterial host to the growth media.

Methods: The modified apoptin gene was optimized using an Integrated DNA Technology (IDT). The gene (606 bp) then ordered and synthesized by Eurofins. The apoptin gene was expressed using E. coli BL21 CodonPlus as host, in cultivation temperature of 37 °C, and 25 °C and purified using Ni-NTA agarose beads. The addition of (His) 6 tag enabled the apoptin to be purified in only one step by using nickel column. The expression and purification data analyzed qualitatively as well as quantitatively using SDS-PAGE. MTT assay was used to identify the antitumor effect of octa arginine-apoptin to two kinds of cancer cells, cervix HeLa cancer cell and colon Widr cancer cell. The viability of cell was analyzed when the cell incubated in the variation concentration protein for 72 h.

Results: The constructed apoptin gene were expressed in E. coli successfully. The MTT assay indicated that Octaarginin-Apoptin was able to induce apoptosis of HeLa and Widr cells lines in a dose-dependent manner. The recombinant apoptin without tagging with octa-arginine, have no ability to induce apoptosis of HeLa and Widr cells lines.

Conclusion: This octa arginine-apoptin may in the future allow the development of a therapeutic protein that is able to kill cancer cells specifically.
A STUDY OF THE HYPOLIPIDEMIC AND ANTIOXIDANT ACTIVITIES OF WHOLE PLANT EXTRACTS OF IPOMOEA AQUATICA FORK IN EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN RABBITS
Authors: Sahid Aziz , Kalpana Gohain
Published: October 2016

Objective: The aim of the study has been to investigate the possible hypolipidemic and antioxidant properties of the whole plant extract of Ipomoea aquatica in experimentally induced hyperlipidemia in rabbits.

Methods: Ethanolic extract of I. aquatica whole plant (EEIAWP) was prepared by percolation method. The extract was evaluated for hypolipidemic and antioxidant activities using 400 mg/kg body weight per day in a high fat diet induced hyperlipidemia in rabbits. The results were analyzed using one-way analysis of variance (ANOVA) followed by Bonferroni’s multiple comparison tests and compared to the normal control, experimental control and the standard drug (atorvastatin 2.1 mg/kg body weight per day) groups. The results were expressed as mean±standard error of mean (SEM). Values with p<0.05 were considered significant.

Results: Oral administration of EEIAWP in the test group showed a significant reduction in the serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and a significant increase in the high-density lipoprotein cholesterol (HDL-C) when compared to the experimental control group. There were also significantly elevated catalase and superoxide dismutase (SOD) activities and significantly lower malondialdehyde (MDA) levels in the test group compared to the experimental group. Similar results were also found in the standard drug group.

Conclusion: The results of our experiment demonstrated that EEIAWP possesses significant antihyperlipidemic and antioxidant activities and hence could be a potential source of medication as an adjuvant to the existing therapy for treatment of dyslipidemia.
Search of inner factors and reserves of construction developmentwith account for the state contribution
Authors: Silka Dmitriy Nikolaevich , Urazova Kseniya Vadimovna
Published: October 2016

The search for inner factors of the development and their control are invariant in the current conditions for fastening the processes of overcoming the crisis. In order to solve the contemporary problems quality changes are necessary. Today in the basis of such changes advancing the state participation in regulating the economy in general and advancing the state order in particular are considered. Though the possibilities of construction development are rather great, it has always been impossible to achieve the essential results without state support.The authors considered the experience and problems of using sovereign state funds in construction in the modern conditions. The ways to efficiently apply the reserves as system solution of national economy problems are investigated - support of con- struction sphere allows facing the challenges of macroeconomy crisis. The authors offer the means of quality change of state order content not only in solving general branch questions, but also the questions of system character of control development of intangible assets.
Projective configurations in projectivegeometrical drawings
Authors: Ivashchenko Andrey Viktorovich , Kondrat’eva Tat’yana Mikhaylovna
Published: October 2016

The article focuses on the optimization of the earlier discussed computer method of obtaining new forms of polyhedra based on projective geometry drawings (trace Dia- grams).While working on getting new multifaceted forms by projective geometry methods based on the well-known models of polyhedra on the first stage of the work it is required to calculate the parameters of projective geometry drawings, and then to build them. This is an often used apparatus of analytical geometry. According to it, at first the parameters of the polyhedron (core system of planes) are calculated, then we obtain the equation of the plane of the face of the polyhedron, and finally we obtain the equations of lines - the next plane faces on the selected curve plane. At each stage of application such a method requires the use of the algorithms of floating point arithmetic, on the one hand, leads to some loss of accuracy of the results and, on the other hand, the large amount of com- puter time to perform these operations in comparison with integer arithmetic operations.The proposed method is based on the laws existing between the lines that make up the drawing - the known configurations of projective geometry (complete quadrilaterals, configuration of Desargues, Pappus et al.).The authors discussed in detail the analysis procedure of projective geometry draw- ing and the presence of full quadrilaterals, Desargues and Pappus configurations in it.Since the composition of these configurations is invariant with respect to projec- tive change of the original nucleus, knowing them, you can avoid the calculations when solving the equations for finding direct projective geometry drawing analytically, getting them on the basis of belonging to a particular configuration. So you can get a definite advantage in accuracy of the results, and in the cost of computer time. Finding these basic configurations significantly enriches the set of methods and the use of projective geometry drawings.
George Moore's Genres
Authors: Bogucki Michael
Published: October 2016

This essay examines George Moore's autobiographical writing, prose fiction, and criticism for new ways of understanding shared tensions between narrative and theatre conventions in the 1880s and 1890s. Defiantly experimenting with speculative and fictionalised reminiscence, inter-arts comparisons, and consideration of an artist's care for their own reputation, Moore offers a rich field for explorations of the longevity and obsolescence of textual forms. Moore's reminiscences of British and French Impressionist painters focus more intently on the emergence of their reputations than their actual technical innovations, extending a habit developed in his novels of the 1880s of treating artistic production as small cells of a much wider network of affiliated entertainment industries. Likewise, his alternately gossipy and prescient art and theatre criticism maps surprising relations between the reception of Japanese prints, naturalism in England, changing theatrical conventions, and the influence of print journalism in ways that defy the usual periodising histories of Victorian and Edwardian fiction.
Adiabatic superconducting cells for ultra-low-power artificial neural networks
Authors: Schegolev Andrey E , Klenov Nikolay V , Soloviev Igor I , Tereshonok Maxim V
Published: October 2016

We propose the concept of using superconducting quantum interferometers for the implementation of neural network algorithms with extremely low power dissipation. These adiabatic elements are Josephson cells with sigmoid- and Gaussian-like activation functions. We optimize their parameters for application in three-layer perceptron and radial basis function networks.
Imagen de México en los relatos de viaje franceses: 1821-1862
Authors: Cramaussel Chantal
Published: October 2016

La imagen de México en los relatos de viaje franceses anteriores a la Intervención denota una fuerte influencia de la obra de Alejandro de Humboldt, pero también de la historiografía inglesa. México es presentado como un país sumamente rico, heredero de una gran civilización cuyo desarrollo fue detenido durante tres siglos de dominación española. Hacia mediados de siglo, los visitantes franceses llegan además a la conclusión de que la nación mexicana no lograría nunca evolucionar sin un régimen político capaz de mejorar lo que ellos llamaban el estado moral de la sociedad. Los cuadros costumbristas de la época, por su parte, muestran una sociedad con una creciente influencia europea, pero que conserva aún rasgos y patrones de conducta propios. La mirada del viajero europeo, bien analizada, resulta de gran interés para el estudioso del siglo xix ya que da parte de eventos y describe situaciones que los mexicanos de la época, por lo general, no encontraban dignos de mencionarse, porque formaban parte de su mundo cotidiano. Pero si bien los viajeros franceses ofrecen interesantes detalles acerca de ciudades, pueblos y haciendas, salta a la vista la ausencia de información referente a los numerosos pueblos indígenas considerados por ellos como externos a la joven nación mexicana.
Les notables de Palmyre
Authors: Yon Jean-Baptiste
Published: October 2016

Ce volume vise à mettre en relief les caractères originaux de Palmyre qui passa d’une société à base tribale à une civilisation qu’influence de plus en plus l’Empire romain. Il utilise pour cela l’épigraphie greco-latine, l’épigraphie sémitique et les donnees archéologiques. 

La ville partage beaucoup de traits avec le reste de la province romaine, malgré sa position excentrée et ses contacts constants avec des zones moins hellénisées, mais reste empreinte des cultures « orientales » (araméenne, mais aussi arabe, iranienne, babylonienne). On peut ainsi définir l’identité de la ville et de ceux de ses habitants qui apparaissent le mieux, les notables. Ils participaient au fonctionnement de la cité grecque de Palmyre : on peut reconstituer des carrières et des familles qui monopolisaient la scène publique. L’aspect classique, gréco-romain, s’accompagne de la permanence de la culture locale (langue, art, religion, onomastique). 

Le commerce caravanier qui fit la gloire de Palmyre est un autre lieu où étudier le rôle des notables et leur influence, hors de la cité et dans l’Empire. À Palmyre même, on peut cartographier leur position sociale grâce à ce qu’ils ont bâti selon les modalités propres à l’évergétisme de Palmyre. Les notables étaient de plus entourés de catégories de population plus discrètes dans les sources (femmes ou affranchis), mais dont l’existence et l’activité n’etaient pas négligeables (ainsi la reine Zénobie). Les notables, par-delà leur propre vie, mettaient en scène la puissance de leur famille, par des constructions de tombeaux. Ces monuments sont aussi le signe d’une pénétration peut-être de plus en plus forte de coutumes qui ont leur origine dans l’Empire romain, sans que disparaissent en aucune manière les traditions originales, en premier lieu l’usage de l’araméen.
Barriers to adherence to antiretroviral treatment in a regional hospital in Vredenburg, Western Cape, South Africa
Authors: Azia Ivo N. , Mukumbang Ferdinand C. , Van Wyk Brian
Published: October 2016

Background: South Africa currently runs the largest public antiretroviral treatment (ART) programme in the world, with over 80% of people living with HIV and/or AIDS on ART. However, in order to appreciate the benefits of using ART, patients are subject to uncompromising and long-term commitments of taking at least 95% of their treatment as prescribed. Evidence shows that this level of adherence is seldom achieved because of a multilevel and sometimes interwoven myriad of factors.Objective: We described the challenges faced by patients on ART in Vredenburg with regard to ART adherence.Methods: A descriptive qualitative research design was used. Eighteen non-adhering patients on ART in the Vredenburg regional hospital were purposefully selected. Using a semistructured interview guide, we conducted in-depth interviews with the study participants in their mother tongue (Afrikaans). The interviews were audio-taped, transcribed verbatim and translated into English. The data were analysed manually using the thematic content analysis method.Results: Stigma, disclosure, unemployment, lack of transport, insufficient feeding, disability grants and alternative forms of therapy were identified as major barriers to adherence, whereas inadequate follow-ups and lack of patient confidentiality came under major criticisms from the patients.Conclusion: Interventions to address poverty, stigma, discrimination and disclosure should be integrated with group-based ART adherence models in Vredenburg while further quantitative investigations should be carried out to quantify the extent to which these factors impede adherence in the community.
DEVELOPING A 3D ROAD CADASTRAL SYSTEM:
COMPARING LEGAL REQUIREMENTS AND USER NEEDS
Authors: Gristina S. , Ellul C. , Scianna A.
Published: October 2016

Abstract. Road transport has always played an important role in a country’s growth and, in order to manage road networks and ensure a high standard of road performance (e.g. durability, efficiency and safety), both public and private road inventories have been implemented using databases and Geographical Information Systems. They enable registering and managing significant amounts of different road information, but to date do not focus on 3D road information, data integration and interoperability. In an increasingly complex 3D urban environment, and in the age of smart cities, however, applications including intelligent transport systems, mobility and traffic management, road maintenance and safety require digital data infrastructures to manage road data: thus new inventories based on integrated 3D road models (queryable, updateable and shareable on line) are required. This paper outlines the first step towards the implementation of 3D GIS-based road inventories. Focusing on the case study of the “Road Cadastre” (the Italian road inventory as established by law), it investigates current limitations and required improvements, and also compares the required data structure imposed by cadastral legislation with real road users’ needs. The study aims to: a) determine whether 3D GIS would improve road cadastre (for better management of data through the complete life-cycle infrastructure projects); b) define a conceptual model for a 3D road cadastre for Italy (whose general principles may be extended also to other countries).
TOWARDS AUTOMATIC PROCESSING OF VIRTUAL CITY MODELS FOR
SIMULATIONS
Authors: Piepereit R. , Schilling A. , Alam N. , Wewetzer M. , Pries M. , Coors V.
Published: October 2016

Abstract. Especially in the field of numerical simulations, such as flow and acoustic simulations, the interest in using virtual 3D models to optimize urban systems is increasing. The few instances in which simulations were already carried out in practice have been associated with an extremely high manual and therefore uneconomical effort for the processing of models. Using different ways of capturing models in Geographic Information System (GIS) and Computer Aided Engineering (CAE), increases the already very high complexity of the processing. To obtain virtual 3D models suitable for simulation, we developed a tool for automatic processing with the goal to establish ties between the world of GIS and CAE. In this paper we introduce a way to use Coons surfaces for the automatic processing of building models in LoD2, and investigate ways to simplify LoD3 models in order to reduce unnecessary information for a numerical simulation.
RIVER MAINTENANCE MANAGEMENT SYSTEM USING THREE-DIMENSIONAL
UAV DATA IN JAPAN
Authors: Kubota S. , Kawai Y.
Published: October 2016

Abstract. River administration facilities such as levees and river walls play a major role in preventing flooding due to heavy rain. The forms of such facilities must be constantly monitored for alteration due to rain and running water, and limited human resources and budgets make it necessary to efficiently maintain river administration facilities. During maintenance, inspection results are commonly recorded on paper documents. Continuous inspection and repair using information systems are an on-going challenge. This study proposes a maintenance management system for river facilities that uses three-dimensional data to solve these problems and make operation and maintenance more efficient. The system uses three-dimensional data to visualize river facility deformation and its process, and it has functions that visualize information about river management at any point in the three-dimensional data. The threedimensional data is generated by photogrammetry using a camera on an Unmanned Aerial Vehicle.
3D GEO: AN ALTERNATIVE APPROACH
Authors: Georgopoulos A.
Published: October 2016

Abstract. The expression GEO is mostly used to denote relation to the earth. However it should not be confined to what is related to the earth's surface, as other objects also need three dimensional representation and documentation, like cultural heritage objects. They include both tangible and intangible ones. In this paper the 3D data acquisition and 3D modelling of cultural heritage assets are briefly described and their significance is also highlighted. Moreover the organization of such information, related to monuments and artefacts, into relational data bases and its use for various purposes, other than just geometric documentation is also described and presented. In order to help the reader understand the above, several characteristic examples are presented and their methodology explained and their results evaluated.
Infecção pelo Papilomavírus Humano (HPV) em mulheres portadoras de HIV/AIDS
Authors: Gonçalves Rodrigues Bianca , Ferreira Holzmann Ana Paula , Gesiele Pereira Santos Amanda , De Almeida Lima Cássio , Fonseca Gonçalves Renata Patrícia , Paiva dos Santos Silvânia
Published: October 2016

Objetivo: Verificar la prevalencia del VPH en mujeres viviendo con VIH/AIDS, y conocer las características sociodemográficas, clínicas y comportamentales de esa población.

Métodos: Estudio documental, exploratorio, descriptivo, cuantitativo, que incluyó los historiales de 32 mujeres viviendo con VIH/AIDS registradas en el CERDI y que realizaron el examen de Papanicolaou en el período de estudio.

Resultados: Se encontraron lesiones de VPH en (15,6%) de las mujeres, siendo clasificada como LSIL bajo grado (60%) de estas. La edad varió de 18 a 39 años (62,5%), casadas o vive en unión estable (75,1%) y la mayoría tiene bachillerato incompleto (37,5%). En cuanto a la renta familiar, 46,9% informó renta igual o inferior a un sueldo mínimo. Iniciaron actividad sexual con edad inferior a 17 años (62,5%), tuvieron menos de cuatro parejas sexuales en la vida (56,3%) y pareja única en el último año (96,9%). Ninguna mujer se refirió al uso regular de preservativos antes del diagnóstico de VIH, siendo que, tras el diagnóstico, 62,5% pasaron a usar el insumo en todas las relaciones sexuales. Historia anterior de DST fue relatada por (40,6%), probable forma de transmisión del virus fue la vía sexual (93,8%) y el diagnóstico de la infección se realizó hace más de cinco años (56,3%) para la mayoría. La mayoría también hace uso de TARV (65,6%) y presentó recuento de células CD4 igual o mayor que 500 células/mL (59,4%), en el último examen realizado.

Conclusiones: Hubo prevalencia de VPH de 15,6%, semejante a otros estudios. Se destaca la necesidad de examen de Papanicolaou periódico para detectar precozmente alteraciones, evitándose el cáncer cervical.
Situación actual de la especialidad de Enfermería Familiar y Comunitaria en España
Authors: Represas Carrera Francisco Jesús , Comesaña Diego Lorena , Carrera García Álvaro , Fernández Fernández Manuel Vidal , Rodríguez Iglesias Francisco Javier , Calvo Pérez Ana Isabel , Díaz Hoyos Rita
Published: October 2016

bjetivo: Conocer la realidad sobre la aplicación del programa formativo en cada una de las Unidades Docentes Multiprofesionales de Atención Familiar y Comunitaria, y también describir la situación actual y perspectivas laborales de los actuales especialistas de Enfermería Familiar y Comunitaria.
Método: Estudio descriptivo de corte transversal realizado durante los meses de Septiembre y Octubre del 2014 a los profesionales residentes y especialistas de Enfermería Familiar y Comunitaria de toda España. Para obtener los datos se facilitó de forma online un cuestionario autoadministrado de carácter voluntario y anónimo, el cual fue elaborado por un grupo de expertos en la especialidad de Enfermería Familiar y Comunitaria pertenecientes a la Asociación Gallega de Enfermería Familiar y Comunitaria de Galicia (AGEFEC).
Resultados: Se estudió una muestra de 342 profesionales. El 69% eran residentes y el 31% especialistas en Enfermería Familiar y Comunitaria. El 54% de los especialistas y el 56% de los residentes indican un déficit en la adquisición de competencias recogidas en el programa formativo de su especialidad. El 46% de los especialistas está trabajando actualmente en el ámbito de la Atención Primaria.
Conclusiones: Resulta de vital importancia ofrecer una formación especializada en Enfermería Familiar y Comunitaria lo más homogenizada posible, sirviendo como un instrumento necesario para garantizar la calidad de la formación en todo el sistema sanitario.
Unexpected Information, Investor Attention, and the Contagion Effect of IPO Withdrawal
Authors: Wang Xiongyuan , He Jie
Published: October 2016

We investigate whether firms’ withdrawals of their initial public offering (IPO) applications, as announced by the China Securities Regulatory Commission (CSRC) on 3 April 2013, lead to a contagion effect on the market reaction to other listed firms sponsored by the same agent. We find that listed firms that have the same sponsor as an “IPO withdrawing firm” face a negative market reaction, suggesting that firms’ IPO withdrawals make investors worried about the quality of sponsors and cause negative abnormal equity returns for listed firms with the same sponsor. We also find that this contagion effect is concentrated among listed firms with good accounting information because this event provides more unexpected negative information for investors. In addition, the contagion effect is concentrated among listed firms with more media or analyst coverage. This is because media and analyst coverage attracts investors’ limited attention, making them more pessimistic and finally leading to an increase in the contagion effect. Our study provides support for the contagion theory and investigates the effectiveness of the CSRC’s special checks on financial statements, which may give some suggestions for the healthy development of the IPO market.
The ethnobotany of psychoactive plant use: a phylogenetic perspective
Authors: Alrashedy Nashmiah Aid , Molina Jeanmaire
Published: October 2016

Psychoactive plants contain chemicals that presumably evolved as allelochemicals but target certain neuronal receptors when consumed by humans, altering perception, emotion and cognition. These plants have been used since ancient times as medicines and in the context of religious rituals for their various psychoactive effects (e.g., as hallucinogens, stimulants, sedatives). The ubiquity of psychoactive plants in various cultures motivates investigation of the commonalities among these plants, in which a phylogenetic framework may be insightful. A phylogeny of culturally diverse psychoactive plant taxa was constructed with their psychotropic effects and affected neurotransmitter systems mapped on the phylogeny. The phylogenetic distribution shows multiple evolutionary origins of psychoactive families. The plant families Myristicaceae (e.g., nutmeg), Papaveraceae (opium poppy), Cactaceae (peyote), Convolvulaceae (morning glory), Solanaceae (tobacco), Lamiaceae (mints), Apocynaceae (dogbane) have a disproportionate number of psychoactive genera with various indigenous groups using geographically disparate members of these plant families for the same psychoactive effect, an example of cultural convergence. Pharmacological traits related to hallucinogenic and sedative potential are phylogenetically conserved within families. Unrelated families that exert similar psychoactive effects also modulate similar neurotransmitter systems (i.e., mechanistic convergence). However, pharmacological mechanisms for stimulant effects were varied even within families suggesting that stimulant chemicals may be more evolutionarily labile than those associated with hallucinogenic and sedative effects. Chemically similar psychoactive chemicals may also exist in phylogenetically unrelated lineages, suggesting convergent evolution or differential gene regulation of a common metabolic pathway. Our study has shown that phylogenetic analysis of traditionally used psychoactive plants suggests multiple ethnobotanical origins and widespread human dependence on these plants, motivating pharmacological investigation into their potential as modern therapeutics for various neurological disorders.
Mood and Brand Extension Judgments: Asymmetric Effects for Desirable Versus Undesirable Brands
Authors: Barone Michael J. , Miniard Paul W.
Published: October 2016

Although prior research (e.g., Barone, Miniard, & Romeo, 2000) has examined positive mood's impact on extensions of evaluations offered by favorably‐evaluated core brands, unknown is whether mood might also influence extension evaluations associated with an unfavorably‐evaluated brand. This research provides evidence of an asymmetrical effect of mood for extensions offered by desirable versus undesirable brands. When a favorably‐evaluated core brand was involved, positive mood facilitated extension evaluations to a greater extent for moderate extensions than for near and far extensions. In contrast, mood failed to enhance the evaluations of any type of extension introduced by an undesirable core brand.
Promoting Consumer Adoption of High‐Technology Products: Is More Information Always Better?
Authors: Ziamou Paschalina (Lilia) , Ratneshwar S.
Published: October 2016

An important challenge for firms commercializing technology‐based new products is to reduce consumers' perceptions of performance uncertainty. We build on prior research in consumer decision making and acceptance of high‐technology products and focus on the role of information in influencing perceptions of performance uncertainty of new product interfaces. In contrast to prior literature, we show here that more information is not always better in reducing performance uncertainty. We argue that the effects of more (vs. less) information on the performance uncertainty of a new interface and consumer adoption intentions of the new product are moderated by the degree of newness of the particular functionality (i.e., set of potential benefits) that is delivered by the new product. We report two experiments that investigate this problem and show that more information helps to reduce performance uncertainty only when the product provides a preexisting functionality. However, high levels of information about the new interface actually intensify performance uncertainty when the product delivers a new functionality. We conclude with a discussion of the theoretical and managerial implications of the findings.
When Do Rewards Have Enhancement Effects? An Availability Valence Approach
Authors: Tietje Brian C.
Published: October 2016

It is commonly argued that although rewards induce behaviors, they undermine attitudes and motivation for subsequent action. This perspective has been applied in a consumer setting to suggest that sales promotions such as coupons will undermine consumer brand evaluations and brand loyalty. Instead of focusing on the undermining effects of promotional rewards, this research applies the availability valence hypothesis (Tybout, Sternthal, & Calder, 1983) to predict and explain when rewards will enhance recipient response. Two experiments demonstrate that an immediate reward from a product‐related source enhances product evaluations by making favorable information more accessible than unfavorable information. Promotions enhance the relative accessibility of favorable information when their benefits are directly experienced and the salience of the promotion's task‐contingency is diminished by maximizing consumer behavioral freedom.
Effect of agomelatine treatment on C-reactive protein levels in patients with major depressive disorder: an exploratory study in “real-world,” everyday clinical practice
Authors: De Berardis Domenico , Fornaro Michele , Orsolini Laura , Iasevoli Felice , Tomasetti Carmine , de Bartolomeis Andrea , Serroni Nicola , De Lauretis Ida , Girinelli Gabriella , Mazza Monica , Valchera Alessandro , Carano Alessandro , Vellante Federica , Matarazzo Ilaria , Perna Giampaolo , Martinotti Giovanni , Di Giannantonio Massimo
Published: October 2016

Objective

Agomelatine is a newer antidepressant but, to date, no studies have been carried out investigating its effects on C-reactive protein (CRP) levels in major depressive disorder (MDD) before and after treatment. The present study aimed (i) to investigate the effects of agomelatine treatment on CRP levels in a sample of patients with MDD and (ii) to investigate if CRP variations were correlated with clinical improvement in such patients.

Methods

30 adult outpatients (12 males, 18 females) with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) diagnosis of MDD were recruited in “real-world,” everyday clinical practice and treated with a flexible dose of agomelatine for 12 weeks. The Hamilton Rating Scale for Depression (HAM-D) and the Snaith-Hamilton Pleasure Scale (SHAPS) were used to evaluate depressive symptoms and anhedonia, respectively. Moreover, serum CRP was measured at baseline and after 12 weeks of treatment.

Results

Agomelatine was effective in the treatment of MDD, with a significant reduction in HAM-D and SHAPS scores from baseline to endpoint. CRP levels were reduced in the whole sample, with remitters showing a significant difference in CRP levels after 12 weeks of agomelatine. A multivariate stepwise linear regression analysis showed that higher CRP level variation was associated with higher baseline HAM-D scores, controlling for age, gender, smoking, BMI, and agomelatine dose.

Conclusions

Agomelatine’s antidepressant properties were associated with a reduction in circulating CRP levels in MDD patients who achieved remission after 12 weeks of treatment. Moreover, more prominent CRP level variation was associated with more severe depressive symptoms at baseline.
Three explanations for extraterrestrials: sensible, unlikely, mad
Authors: Conway Morris Simon
Published: October 2016

The Fermi Paradox (or Question) has moved back into central focus. This is for a number of reasons, not least the evidence for both the abundance and antiquity of many extra-solar systems, the extrapolation of current technological trends to suggest that even inter-galactic colonization (by self-replicating machines) is plausible (if not desirable), and the recurrence of evolutionary solutions (convergence) in the terrestrial biosphere suggesting that features such as intelligence and tool-making are not fortuitous outcomes, but frequent if not universal. Here I review the three possible solutions to the Fermi Paradox. First, extraterrestrials certainly exist (and may be abundant), but for one reason or another (probably mundane) we have not yet met them, or at least found evidence for their existence. Second, against all expectations, we are alone. Third, we have entirely misunderstood the sort of universe we live in and have become unwitting hostages to a strict materialist explanandum that in refusing to acknowledge the other realities of our Universe has derailed any prospect of explaining the apparent absence of extraterrestrials.
How News Type Matters
Authors: Andersen Kim , Bjarnøe Camilla , Albæk Erik , De Vreese Claes H.
Published: October 2016

Abstract. Today, citizens have the possibility to use many different types of news media and participate politically in various ways. This study examines how use of different news types (hard and soft TV news as well as printed and online versions of broadsheet and tabloid newspapers) indirectly affects changes in offline and online political participation through current affairs knowledge and internal efficacy during nonelection and election time. We use a four-wave national panel survey from Denmark (N = 2,649) and show that use of hard TV news and broadsheets as well as online tabloids positively affects changes in both offline and online political participation through current affairs knowledge and internal efficacy. Use of soft TV news and printed tabloids has a negative indirect effect. These results are more pronounced for online political participation and during election time. However, use of soft TV news also has a positive direct effect on changes in political participation, which suggests a positive impact via other processes.
Projection of Visceral Needs
Authors: Ahn Janet N. , Oettingen Gabriele , Gollwitzer Peter M.
Published: October 2016

Abstract. People’s immediate needs influence how they perceive other’s needs – people project their needs onto others. Two studies sought to replicate and extend previous research by identifying moderators of need projection: need satisfaction and a global sense of similarity. Projection increased when a strong need to quench one’s thirst was induced and not satisfied (Study 1). Projection of the need to quench one’s thirst increased when existing thirst and the global sense of similarity with the target person were high, but again only when the need was not satisfied (Study 2). Visceral needs influence judgments about other people’s needs when the individual is experiencing the need in a given moment; lingering effects are not observed once that need is satisfied.
Developments in Ice Core Research on Past Climate Change
Authors: Lecavalier Benoit , Markle Bradley
Published: October 2016

IPICS 2016 Open Science Conference; Hobart, Australia, 7–11 March 2016
Animal diversity and ecosystem functioning in dynamic food webs
Authors: Schneider Florian D. , Brose Ulrich , Rall Björn C. , Guill Christian
Published: October 2016

Species diversity is changing globally and locally, but the complexity of ecological communities hampers a general understanding of the consequences of animal species loss on ecosystem functioning. High animal diversity increases complementarity of herbivores but also increases feeding rates within the consumer guild. Depending on the balance of these counteracting mechanisms, species-rich animal communities may put plants under top-down control or may release them from grazing pressure. Using a dynamic food-web model with body-mass constraints, we simulate ecosystem functions of 20,000 communities of varying animal diversity. We show that diverse animal communities accumulate more biomass and are more exploitative on plants, despite their higher rates of intra-guild predation. However, they do not reduce plant biomass because the communities are composed of larger, and thus energetically more efficient, plant and animal species. This plasticity of community body-size structure reconciles the debate on the consequences of animal species loss for primary productivity.
Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluoxetine
Authors: Pei Siran , Liu Li , Zhong Zhaomin , Wang Han , Lin Shuo , Shang Jing
Published: October 2016

Fluoxetine is widely used to treat depression, including depression in pregnant and postpartum women. Studies suggest that fluoxetine may have adverse effects on offspring, presumably through its action on various serotonin receptors (HTRs). However, definitive evidence and the underlying mechanisms are largely unavailable. As initial steps towards establishing a human cellular and animal model, we analyzed the expression patterns of several HTRs through the differentiation of human induced pluripotent stem (hiPS) cells into neuronal cells, and analyzed expression pattern in zebrafish embryos. Treatment of zebrafish embryos with fluoxetine significantly blocked the expression of multiple HTRs. Furthermore, fluoxetine gave rise to a change in neuropsychology. Embryos treated with fluoxetine continued to exhibit abnormal behavior upto 12 days post fertilization due to changes in HTRs. These findings support a possible long-term risk of serotonin pathway alteration, possibly resulting from the “placental drug transfer”.
Antiangiogenic therapy using endostatin increases the number of ALDH+ lung cancer stem cells by generating intratumor hypoxia
Authors: Yu Yang , Wang Yu-yi , Wang Yi-qin , Wang Xia , Liu Yan-Yang , Wang Jian-Tao , Du Chi , Wang Li , Li Mei , Luo Feng , Jiang Ming
Published: October 2016

Antiangiogenic therapy is becoming a promising option for cancer treatment. However, many investigations have recently indicated that these therapies may have limited efficacy and the cancers in most patients eventually develop resistance to these therapies. There is considerable recently acquired evidence for an association of such resistance with cancer stem-like cells (CSLCs). Here, we used xenograft tumor murine models to further suggest that antiangiogenic agents actually increase the invasive and metastatic properties of lung cancer cells. In our experiments with murine lung cancer xenografts, we found that the antiangiogenic agent endostatin increased the population of ALDH+ cells and did so by generating intratumoral hypoxia in the xenografts. We further showed endostatin to cause an increase in the CSLC population by accelerating the generation of tumor hypoxia and by recruiting TAMs, MDSCs and Treg cells, which are inflammatory and immunosuppressive cells and which can secrete cytokines and growth factors such as IL-6, EGF and TGF-β into the tumor microenvironment. All these factors are related with increased CSLC population in tumors. These results imply that improving the clinical efficacy of antiangiogenic treatments will require the concurrent use of CSLC-targeting agents.