bluuebunny/crossref_metadata_2025 huggingface dataset:
The Integration of Dynamic Transmission in Xuzhou Paper-Cutting Art and Contemporary Design Language
Authors: Hu Xiaoqian
Published: October 2024

This article discourses on how the inheritance and innovation in paper-cutting art have taken place through its integration with modern design language. Xuzhou paper-cut is regarded as representative of China's traditional folk art, carrying a rich cultural heritage, but it faces both challenges and opportunities that come with modern society. In the course of reviewing the development history of Xuzhou paper-cutting, the value of Xuzhou paper-cut as intangible cultural heritage was discussed. This paper will seek to find out the possibility of application for Xuzhou paper-cutting in modern design with both qualitative and quantitative methods, including questionnaires and interviews. Successful examples are used in this research to look for evidence that effectively proves traditional paper-cutting combines well with the principles of modern design in developing concepts, artistic expressions, and cultural symbolism. It shows that Xuzhou paper-cutting has a great potential to apply in modern design, and education, exhibitions, and community activities will be also necessary to revive it. On the other hand, traditional craft could adapt to current social needs only when the design language has been innovated. The research brought in new input with regard to integrating traditional culture with modern design from a theoretical and practical point of view, thus serving as an informant for the direction of further research in heritage and design integration.
Aggressive Monetary and Fiscal Policy Impact on Household Wealth: A Comparative Analysis of China and Japan
Authors: HU RUIZHE
Published: October 2024

This paper uses a Vector Autoregression (VAR) model and linear regression to
analyze the effects of aggressive monetary policies (such as RRR cuts and interest
rate reductions) and fiscal measures (like government bond issuance) on household
wealth in China, with a focus on housing assets. A comparative analysis with Japan
is conducted to explore the transmission mechanisms and the policies’ impacts on
housing prices, wealth distribution, and economic growth. The findings highlight
the significant role of monetary and fiscal interventions in shaping the housing
market dynamics across different economic contexts.
Emerging Threat of Marburg Virus Disease: Epidemiology, Clinical Management, and the One Health Strategy for Prevention and Control
Authors: Muvunyi Claude Mambo , Ngabonziza Jean Claude Semuto , Bigirimana Noella , Butera Yvan , Nsanzimana Sabin , Kaseya Jean , Siddig Emmanuel Edwar , Ahmed Ayman
Published: October 2024

Objectives: Marburg virus disease (MVD), caused by the Marburg virus, is a severe zoonotic viral hemorrhagic fever with high mortality that threats the Global Health Security. Marburg virus is on the WHO list for the next pandemic-prone pathogens it always emerges in outbreaks. Considering it is current involvement in outbreak in Rwanda, there is an urgent need for up to date information to inform policymaking, resources mobilization, strategic planning and guide the implementation of cost-effective response strategies. Methods: Through technical and scientific consultancies with experts and reviewing publicly existed knowledge, we collected and synthesized available information about the disease and summarized it into a brief evidence to inform policymakers, public health leaders, and frontline responders in developing and implementing cost-effective prevention and control measures. Results: We have identified the historical outbreaks and geographical distribution of MVD, main clinical signs and diagnostic tools, primary reservoir, transmission dynamics and case management protocol. More importantly, we summarized the best practices for multisectoral One Health strategy for the prevention and control of MVD outbreaks including strict implementation of WASH and infection prevention measures, isolation of infected humans and animals, contact tracking for confirmed cases, and International Health Regulations (IHRs 2005). High risk populations such as frontline responders including healthcare providers and community health worker should be prioritized for the experimental vaccination. Conclusions: In lack of licensed treatment or vaccine, cost-effective preparedness and response strategy to MVD should focus on preventive measures including community engagement, reduced contact between humans and reservoirs, supportive care and isolation of patients, and proper waste management.
Mezar Taşlarında Ebcetle Tarihlendirme: Kastamonu Şeyh Şaban-ı Velî Haziresi Örnekleri
Authors: Mutlu Mehmet
Published: October 2024

Bu araştırma, Kastamonu Şeyh Şaban-ı Velî Külliyesi haziresinde bulunan ebcetle tarih düşülmüş mezar taşlarını tespit ve analiz etmek amacıyla gerçekleştirilmiştir. Türk-İslam sanatındaki kitabeler, diğer sanat formlarıyla birlikte zaman içinde gelişim göstermiştir. Başlangıçta daha basit ifadelerle ortaya çıkan kitabeler, özellikle Osmanlı döneminde edebi metinlerin eklenmesiyle zenginleşmiş ve edebi bir platform haline gelmiştir. Ayrıca, edebiyatta ustalık göstergesi olarak kabul edilen ebcedin mezar taşlarında kullanılması, hayranlık uyandıran örneklerin ortaya çıkmasına neden olmuştur. Kastamonu'daki Şeyh Şaban-ı Velî Külliyesi haziresi, az ama oldukça nitelikli mezar taşlarının bulunduğu bir mezarlık alanıdır. Bu alan, seçkin kişilerin defnedildiği bir yer olup, mezar taşları malzeme, işçilik, kitabe ve yazı gibi özelliklerde oldukça nitelikli örnekler sunmaktadır. Bu özelliklerin yanı sıra, kitabelerinde Türk sanatının önemli ve ilgi çekici bir alanını oluşturan ebcetle tarih düşürme tekniğinin kullanıldığı örnekler de bulunmaktadır. Bu çalışmada, hazirede tespit edilmiş olan dört adet ebcet kitabeli mezar taşında kullanılan ebcet tekniğinin çözümlenmesi ve değerlendirilmesi yapılacaktır. Bu konu üzerine daha önce benzer bir çalışma yapılmamış olup, bu açıdan araştırma özgündür ve mezar taşları bu yönüyle ilk kez değerlendirilecektir.
Estratégias de Educação em Saúde para Aumentar a Adesão das Mulheres ao Exame de Papanicolau
Authors: Santos Rafael de Lima , Borges Gabriella Marques Fernandes , Faria Gustavo Ferreira de , Jorgetto Giovanna Vallim , Vormittag Claudia Camargo de Carvalho , Marini Danyelle Cristine
Published: October 2024

O câncer do colo do útero é uma das principais causas de morte entre mulheres no Brasil, com altas taxas de incidência previstas para os próximos anos. Este estudo visa avaliar a eficácia das estratégias de educação em saúde na promoção da adesão ao exame de Papanicolau, essencial para a detecção precoce de lesões precursoras do câncer cervical. A revisão integrativa da literatura foi realizada seguindo as diretrizes PRISMA, com uma análise detalhada de artigos que abordam intervenções educativas em saúde pública. Os resultados indicam que as campanhas educativas, especialmente em ambientes comunitários, são eficazes em aumentar a adesão ao exame, contribuindo significativamente para a redução da incidência e mortalidade do câncer cervical. A análise destacou a importância de políticas públicas eficazes e da educação contínua das mulheres sobre a importância do exame, além de identificar barreiras como o acesso limitado aos serviços de saúde e a falta de conhecimento, que precisam ser superadas para melhorar os índices de rastreamento. Este estudo reforça a necessidade de esforços contínuos na promoção de estratégias educacionais como ferramenta crucial na prevenção do câncer cervical.
Giftedness and the Overexcitability Rabbit-Hole Trap
Authors:   Clever Kids Consultancy, Wellisch Mimi
Published: October 2024

Giftedness and Dabrowski's Theory of Positive Disintegration (TPD) have been firmly linked since the Columbus Group's 1991 statement on giftedness and asynchrony. The theory's overexcitabilities (OEs) factor has been the main association with giftedness. Although OEs include certain characteristics associated with giftedness, they also include negative aspects not found in research on gifted characteristics. Instead, those negative aspects May be signs of learning and other disorders, or of mental health issues. Because positive aspects of OEs have been shown to fit within the five-factor model of personality, and because the negative aspects May be signs of neurodiversity, I argue that the OE association with giftedness May be superfluous or even misleading. Three parents of gifted children are cited, revealing the consequences of receiving information about OEs with their children's assessment reports as the only guide for possible future problems. I offer suggestions, including replacing OE lists with research-based gifted characteristics.
Developing a Pancasila students' character instrument: Proof of construct validity and estimation of construct reliability
Authors: Mistiani Wiwin , Istiyono Edi , Syamsudin Amir , Ghazali Nor Hasnida Md.
Published: October 2024

This study aims to prove construct validity and estimate construct reliability of the character scale of Pancasila students by using confirmatory factor analysis. The research approach used is quantitative with a sample of 200 high school students selected at random. This study measured the variables by six aspects, 15 indicators, and 20 questions. The six aspects include faith and piety to God Almighty, global nationality, cooperation, independence, critical reasoning, and creativity. The data analysis technique used is confirmatory factor analysis. The study results concluded that the instrument for assessing the character of Pancasila students in high school had a loading factor of more than 0.4 and a value of more than 0.96 which was declared valid and significant. Likewise, the instrument has been declared fit in testing the goodness of fit model. Thus, this finding indicates that the observed and performance covariance matrices are not significantly different. This study recommends a scale to measure the character of Pancasila students in senior high school.
Effects of learning languages on volunteering
Authors: Nursultankyzy Ailina Makhmut , Khan Natalya Nikolaevna , Kassymova Gulzhaina Kuralbaevna , Kalimoldayeva Ardak Kenesbayevna , Ketebayeva Elmira Kanatovna
Published: October 2024

Learning languages is an important aspect of modern times that influences people's thinking which was studied by many researchers. Today the knowledge of different languages is becoming an increasingly significant aspect of volunteering, having a profound impact on its various aspects. This article discusses the importance of knowing foreign languages for developing empathy, improving communication skills, and expanding the worldview of volunteers using a questionnaire consisting of 12 questions divided into three main sections (empathy, communication skills, and worldview). Each section includes four questions related to the specific aspect that are given randomly. Responses were received from random respondents from various universities in Kazakhstan in Almaty through the use of a Likert scale in the questionnaire. This article, based on the collected materials and the results of other studies, shows that learning languages has a positive effect on the development of empathy, as it helps to better understand a person, and their mood, and can help to imagine yourself in the place of another. In addition, it shows how knowledge of languages affects the development of communication skills in a volunteer, as it helps to better understand a person, be a good listener and at the same time maintain a conversation. The data also showed that learning languages can have a positive impact on the development of things like motivation and analytical thinking and encourages people to try new things.
Analysis of the impact of mechanisms of integration of university science into the regional innovation system on the spatial development of the Voronezh region
Authors: Golikova G. V. , Prityko E. A. , Makarova O. S. , Kazmin A. A.
Published: October 2024

Relevance. University science is the basis for the progressive development of the regions of the Russian Federation, providing new knowledge and ideas, turning knowledge into technology and accelerated development of the cultural environment. The introduction of scientific research into the educational process is necessary and important conditions for maintaining the high professional level of teachers, the formation of professional competencies, and advanced training of future specialists. In the last few years, the main economic processes have demonstrated positive dynamics, which indicates the effectiveness of the implemented strategy of socio-economic development of the region, as well as an effective policy of spatial development of the territory are key factors in achieving a positive trend in the development of the region. Minister of Science and Higher Education V.N. Falkov in April 2024 He stated the need to transform the higher education system, focusing on specialized higher education based on an interdisciplinary approach that will more effectively integrate university science into regional spatial development and the national innovation system.

The purpose of the study is to determine the mechanisms of integration of university science in the spatial development of the Voronezh region through the innovation system.

Objectives: to analyze the impact of the mechanisms of integration of university science on the trends of spatial development; to analyze scientific and technological development; to formulate the main conclusions about university science as part of the socio-economic system of the territory.

Methodology. The general scientific methods of logical analysis, method of desk research, method of systematization, descriptive method were used in the study. Results. The study revealed the key factors that contributed to the positive dynamics of the economy of the Voronezh region and considered the mechanisms of integration of university science into the regional innovation system.

Conclusions. In the realities of scientific and technological development there is a need to improve the methods of integration of university science into the regional innovation system, and recommendations related to the optimization of spatial development of the Voronezh region in order to improve the quality and attractiveness of university science on the basis of innovative aspects functioning in the region have been proposed.
Management of scientific and technological regional development in the Volga Federal District: review of government programs
Authors: Gataullina A. A. , Zyabbarova A. A.
Published: October 2024

Relevance. In light of the growing interest in the scientific and technological development of regions, setting goals for scientific and technological advancement at the national level, the issue of developing programs for the development of science and education leading to the technological sovereignty of the country becomes relevant.

The purpose is to analyze the ongoing programs for scientific and technological development of the regions of the Volga Federal District, as well as individual indicators characterizing the dynamics of the scientific and educational sector of the constituent entities of the Russian Federation.

Objectives: conduct an economic and statistical analysis of the main indicators characterizing the scientific and technological progress of the regions of the Volga Federal District; identify regions of the Volga Federal District in which state programs for scientific and technological development have been developed, and consider their features.

Methodology. The study used methods of economic-statistical and comparative analysis.

Results. A review of state programs for scientific and technological development shows that four pilot regions of the Volga Federal District (Nizhny Novgorod region, Republic of Tatarstan, Republic of Bashkortostan and Republic of Mordovia) have already developed corresponding programs, and two regions (Orenburg region and Perm Territory) are under development. The remaining regions either have state programs that indirectly indicate the development of scientific and technological potential, or they do not exist.

Conclusions. Scientific and technological development programs represent an important document that defines strategic guidelines for the development of science, technology and higher education. Regions that have already developed state programs for scientific and technological development have a high scientific reserve and are located in the top positions in the National Rating of Scientific and Technological Development of Regions. Such regions show strong results in the scientific and educational sector, which contributes to improving the economic and social development of the region. A systematic analysis of these programs makes it possible to identify their impact on various aspects of social life, as well as determine the effectiveness of the measures taken and mechanisms for achieving the set goals. It is important to take into account the variety of approaches to the development and implementation of strategic programs, which should be aimed at the unique characteristics of the country’s regions, their bottlenecks and development prospects, taking into account an assessment of their potential.
Choosing a promotion channel for a startup project in the modern media space
Authors: Kryzhanovskaya O. A.
Published: October 2024

Relevance. The startup market is becoming increasingly saturated. Effective promotion channels allow you to stand out from the competition and attract the attention of the target audience. Startups often work with a limited budget. Optimizing the choice of promotion channels is critical to maximizing the return on investment. Modern media management covers many platforms (social networks, blogs, video hosting, etc.). Choosing the right channel helps to optimally use resources and ensure maximum visibility. Different channels are suitable for different target groups. An effective choice of promotion channel helps to more accurately reach the desired audience, taking into account its preferences and behavior. Consumers are increasingly paying attention to digital communication channels. Taking into account current trends and preferences allows you to improve interaction with the audience. The influence of social networks and bloggers is becoming an important mechanism for creating trust among consumers. This can significantly increase the recognition of a startup. All this emphasizes the importance of a strategic approach to choosing promotion channels for a successful launch and sustainable growth of a startup project in the modern media landscape.

The purpose of the study is to choose a promotion channel for a startup project in the modern media space.

Objectives: to substantiate the relevance of choosing a promotion channel for a startup in the modern media space; to study the demand and effectiveness of modern promotion channels; to use in practice the method of multicriteria selection of promotion channels for a startup project; to substantiate the results obtained.

Methodology. The research methodology is based on the methods of comparison and comparison, deduction and induction, qualitative and quantitative analysis, as well as the Churchman-Ackoff multi-criteria assessment method.

Results. The study substantiates the relevance of choosing a promotion channel for a startup in the modern media space; the demand and effectiveness of modern promotion channels are studied; the method of multi-criteria selection of channels for promoting a startup project was used in practice; the obtained results were substantiated.

Conclusions. The effectiveness of the selected channels for promoting a startup project in the modern media space was proven as conclusions.
UN Assistance to African countries in building climate-resilient agriculture
Authors: Kuzmina V. M. , Parkhomchuk M. A.
Published: October 2024

Relevance. Africa is the mirror and quintessence of modern international processes. The continent faces a gigantic number of challenges, some of an existential nature. But at the same time, there is an active search for ways to solve them.

The purpose is to consider the experience of forming climate-resilient agriculture on the example of individual African countries and the role of the UN in this process.

Objectives: to characterize the conditions and reasons for the formation of climate-resilient agriculture in the African region; assess the policies of the governments of Kenya, Tanzania, Ethiopia, and Rwanda on the development of climate-resilient agriculture.

Methodology. The comparative research method was used in the study of agricultural development programs in African countries. Chronological and historical methods of studying legal documents, programs of the United Nations, FAO, NEPAD, Kenya, Tanzania, Ethiopia, Rwanda aimed at the formation of climate-resilient agriculture. A statistical research method for operating with data from the statistical databases of Globaleconomy and the World Health Organization.

Results. The introduction of new technologies in agriculture is a condition for saving the environment, which is under pressure from two sides: global climate change and unprecedented growth in the population and its needs. One of the most important areas is to increase the productivity of agriculture, the solution of this urgent task will depend on the introduction of new technologies: seeds, fertilizers, irrigation, plant protection, etc.

Conclusions. The introduction of programs and technologies for the formation of climate-resilient agriculture in African countries requires significant funding and institutional and legal preparation.
HR-brand: features of formation and development
Authors: Polischuk O. A. , Gracheva N. A. , Isaev P. A. , Fedorinov A. V.
Published: October 2024

Relevance. The development of HR management stems from the need for organizations to attract and retain highly qualified employees in the competitive environment of the modern labor market. HR branding is a strategy based on the formation and support of a positive image of the company in the eyes of employees, as well as the company's commitment to the principles and values that bind employees and the organization. Positive evaluations of the organization's employees and their recommendations can attract new specialists and strengthen the company's reputation as a reliable and attractive employer.

The purpose of the article is to study a special category of reputation and perception of the company – the HR brand.

Objectives: to study the conditions for building an HR brand, its structure and key elements; to consider the history of the origin of the idea of HR branding; to assess the interest in creating a special reputation in the field of human resource management; to justify why it is impossible to build an EVP (employer's value proposition) without HR branding.

Methodology. In the course of scientific research, empirical, theoretical, statistical methods and methods of graphical representation were used.

Results: the theoretical aspects of building a company's HR brand were studied; the popularity of this topic in science and business was shown. A set of knowledge about the features of HR branding in the Russian and foreign markets has been formed and the prospects for the development of this area are shown. It shows why it is important to work on an HR brand and how to start forming a positive image of the company, its reputation and prestige.

Conclusions. The article emphasizes the relevance and importance of the topic under consideration, taking into account the latest trends, prerequisites and prospects for new companies. The possibilities that open up for an employer when forming an original and popular HR brand are considered.
Modern information technologies for studying the cost of working time as an important tool for effective management of business processes
Authors: Kopteva Zh. Yu. , Tomakova I. A. , Sadikov R. A.
Published: October 2024

Relevance. In the context of economic, social and socio-political changes, growth and increased competition, it is becoming increasingly interesting to study the issues of scientific organization and labor rationing, as well as factors affecting labor productivity, and, ultimately, the effectiveness and profitability of production processes in general. There is an objective need to improve not only the methods of managing the cost of working time, but also to skillfully apply modern digital technologies. That is why it is so important to develop and modify, in accordance with the requirements of the market environment, methods, tools and methods of analysis using artificial intelligence (AI) when studying the cost of working time of employees of an organization.

The purpose is based on the study of theoretical and methodological approaches to improving the system of organization and rationing of labor, to provide a scientific justification for the relevance of the development of the processes of accounting for working hours of employees of the organization through the integration of modern information technologies.

Objectives: to analyze the existing approaches to the organization and rationing of labor; to identify the potential of integrating modern information technologies into the processes of working time accounting; to develop practical recommendations for improving the system of accounting for the working hours of employees of the organization using modern information technologies.

Methodology. The theoretical and practical basis for the study of modern approaches to the modernization of the system of organization and rationing of labor at the enterprise were the methods of analyzing literary sources, statistical data, expert assessments, as well as using an integrated approach.

Results. The result of the research in the work is a comprehensive analysis of the use of artificial intelligence (AI) in studying the cost of working time to modify the processes of rationing labor functions through the integration of information technologies.

Conclusions. In the course of the study, we proved the positive effect of the introduction of modern information technology systems at the enterprise, as well as scientifically substantiated the relevance of the development of processes for analyzing the cost of working time and rationing employees of enterprises through the integration of modern information technologies.
The influence of reflexive modernity on the change of human capital
Authors: Komornikova O. M.
Published: October 2024

Relevance is due to the need to revise approaches to the theoretical understanding of the concept of "human capital" in modern society, since it is considered as a resource for the development of society, solving many current social problems, as well as confronting new risks. The concept of "reflexivity" as a social phenomenon also needs conceptual development. It is also necessary to identify the relationships between these phenomena.

The purpose is to consider how the content of the phenomenon of human capital is transformed in the conditions of the formation of the socio-cultural structure of the information society, including the growing reflexivity of social interaction.

Objectives: to identify the key features of understanding the phenomenon of reflexivity (reflection) in philosophy, psychology, sociology; the specifics of this phenomenon in the context of the formation of the information society, as well as the impact of this process on the content component of human capital in modern society.

Methodology. The author relies on the achievements of related sciences in the field of the study of reflexivity. The analysis of the problem is based on the ideas and principles of systemic, synergetic, activity-based approaches, as well as the provisions of the theories of emergent effects and human capital.

Results. The article substantiates the idea that the transition to a new type of social organization, accompanied by the appearance of new characteristics in the social system, led to the development and strengthening of the importance of reflexivity of society. At the same time, the requirements for the individual are changing and the content of human capital is being revised. This process is conditioned by the need to increase awareness, objectivity of ideas about the system of social relations in conditions of expanding individual freedom, its role in social processes, increasing the volume of information produced by society and the subjects involved in this process.

Conclusions. Reflexivity as a characteristic of the social system appears at the later stages of the development of society. The basis of its formation was the evolution of psychological processes in humans and a qualitative change in the organization of society. On the one hand, there is an expansion of the potential of the individual and society, on the other ‒ the risks they have to face. Objectively the content of human capital is expanding, and social demands on it are growing. The ability to reflect seems to be an integral part of it. It involves the mastery of a person's ways of thinking and intellectual techniques for perceiving processes and events in society, which was previously the lot of the elite; internalization, rather than declaring universal values.
About the characteristic features of Russians (territorial and settlement aspect)
Authors: Lebedeva L. G.
Published: October 2024

Relevance. In the post-Soviet era, changes in the consciousness and behavior of the masses of people became inevitable. The study of the structure of characteristic features (consciousness and behavior) of Russians (both positive and negative) in modern conditions is of great scientific and practical interest.

The purpose is to use sociological materials to identify the hierarchical structure of characteristic positive and negative traits (consciousness and behavior) of Russians, including by territorial settlement groups.

Objectives: to analyze the assessments of positive and negative traits inherent, in the opinion of respondents, to people of their generation; to identify their hierarchical structure and characteristics by territorial settlement groups.

Methodology. The sociological survey and the sampling method, methods of grouping data, their analysis and generalization, and correlation analysis were used.

Results. The leading features (both positive and negative) inherent, in the opinion of respondents, to people of their generation are revealed, as well as the relationships between them by territorial settlement groups are revealed.

Conclusions. The positive features that have taken the leading places indicate the high potential of humanism and harmonious personality development among the majority of Russians. The negative traits that took the leading places indicate a relatively low level of sociality, social empathy and social responsibility of significant masses of people (according to respondents' estimates). However, the respondents' overall assessment of people of their generation is predominantly positive, which gives grounds for social optimism. At the same time, although the differences between territorial settlement groups in both positive and negative features are not antagonistic, they can be the basis for elements of contradictions and conflicts. Consistent active work of advanced social forces is necessary, first of all, by means of education to strengthen the positive traits of people as a "situationally dominant factor" and a center of attraction, a positive pole, especially for the younger generations.
Substantive behavioral aspects of consumer behavior in the conditions of sanctions pressure on the Russian economy
Authors: Polozhentseva Yu. S. , Logvinova I. O.
Published: October 2024

Relevance. Sanctions pressure on the economy of the Russian Federation is one of the most important factors influencing consumer behavior and their consumer preferences. Under sanctions, many social, economic and political aspects influence consumer behavior, from which new consumer trends and changes in consumer behavior emerge.

The purpose is to explore the substantive behavioral aspects of consumer behavior under the conditions of sanctions pressure on the Russian economy.

Objectives: study changes in consumer preferences in connection with global crises; analyze changes in consumer behavior depending on various factors and price dynamics as a factor in consumer behavior; explore the influence of cognitive distortions on the meaningful behavioral aspects of consumers; propose the concept of business company plans in accordance with new consumer expectations.

Methodology. In the process of research, general scientific methods of logical and statistical analysis, field research, as well as qualitative and quantitative analysis were used. Results. The survey showed that consumers have become more frugal and choose domestic brands in order to save money, the study of the impact of cognitive distortions on consumers showed that society is prone to a pessimistic attitude in terms of adopting new domestic products and brands.

Conclusions. A business plan under sanctions pressure, aimed at the novelty of the product and its effectiveness, will help companies promote their goods and services on the Russian market during the period of sanctions pressure. Focusing on changing the object of purchase, place of purchase (online trading if possible), timing and methods of procurement in accordance with new motives and customer expectations will give companies an advantage in conditions of market instability and changing behavioral aspects of consumers.
Stages of development of a methodological approach for assessing the effectiveness of digital transformation projects of an industrial enterprise
Authors: Babkin A. V. , Tashkinov A. G.
Published: October 2024

The relevance of the study is determined by the fact that the digital transformation of the enterprise becomes the cornerstone of the organization's success: enterprises use digital technologies to optimize production processes, logistics operations, improve product quality, customer service and develop digital innovation.

The purpose of the study is to develop key stages of the formation of a methodological approach to assess the effectiveness of digital transformation projects of an industrial enterprise based on the determination of the main aspects of digital transformation of enterprises in terms of the formation of a new business model of the enterprise in a single information (digital) space.

The objectives of the study are to analyze publications in terms of clarifying the term "digital transformation project of an industrial enterprise" and formulating the author's definition of "digital transformation project of an industrial enterprise" from the standpoint of developing the production and economic system; identification of distinctive features of IT projects and projects of digital transformation of an industrial enterprise; analysis of the tools for assessing management digital decisions; development of stages of methodological approach formation for evaluation of efficiency of digital transformation projects.

Methodology. The following methods were used during the study: comparative analysis, observations, generalization, abstraction, modeling. In the course of scientific research, methods of deduction and induction, systemic and critical analysis were used.

Results. As a result of the study, the authors formulated the definition of the definition "project of digital transformation of an industrial enterprise" from the standpoint of developing the production and economic system. Distinctive features of IT projects and digital transformation projects of an industrial enterprise have been identified. Based on the proposed structure of the methodological approach and the analysis of tools for assessing management digital decisions, the stages of forming a methodological approach for assessing the effectiveness of digital transformation projects of an industrial enterprise were developed.

Conclusion. The authors conclude that the developed stages of forming a methodological approach to assess the effectiveness of digital transformation projects of an industrial enterprise will be useful for enterprise managers to ensure strategic competitive success and increase operational efficiency.
Novel FLNC Gene Variant Associated with Hypertrophic Cardiomyopathy
Authors: Cedeño-Escudero. José A. , Sotillo-Bent. Luis A. , Vega- Cuellar. Carolina , González-Angulo Rolando , Medina-Batista Evelyn , Sotillo-Lindo José , Méndez-Rosado. Luis A.
Published: October 2024

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy, affecting approximately 1 in 500 people. It is the most common genetic cardiomyopathy inherited as a Mendelian trait in approximately 50% of patients, mainly due to pathogenic variants in genes encoding sarcomeric proteins. Mutations in the sarcomeric protein filamin C (FLNC) gene, with a cytogenetic localization on 7q32.1, have been linked to hypertrophic cardiomyopathy, as they have been determined to increase the risk of ventricular arrhythmia and sudden death. We present the case of a patient with HCM recognized by magnetic resonance imaging and echocardiography with a family history of cardiopathies. The molecular study in this patient was performed by next-generation sequencing on the Illumina MiniSeq instrument, comparing the results with international databases. In genetic studies, a novel mutation in the protein FLNC was detected. It is heterozygous, missence type. It is a variant where Cytosine is changed by timina at position 6305 of the FLNC gene. This produces the change of the amino acid proline by leucine at position 2102 of the Filamin C protein. The rare variant is located in Ig-like domain 19 within the ROD2 domain. This variant report suggests that there may indeed be a direct relationship between FLNC variants, mainly the ROD2 domain, and HCM. We think this new result should be considered for future genetic counseling of families affected by this type of cardiomyopathy.
Case Reports of Patients Using Homeopathy in Which Complete Healing Was Observed: A Literature Review
Authors: de Carvalho Jozélio Freire , Lerner Aaron
Published: October 2024

To systematically review the literature for cases using homeopathy in which complete healing was observed. Scielo, Pubmed, CINAHL, and Embase databases were systematically screened for case reports and series of patients successfully cured by homeopathy between 1966 and August 2022. Language limitation was not used. Forty-nine articles, comprising 191 patients, were depicted. Most of them had dermatological conditions (12 papers, 71 patients), followed by infectious (7 papers, 31 patients), neuropsychiatric (10 publications, 11 patients), vascular and hematological (6 manuscripts, 6 patients), and miscellaneous (11 papers, 52 patients) categories. All of them reported cases that were cured of the clinical condition. This article summarizes the case reports in which homeopathy was used and shows the healing of the different treated diseases.
EFFECTS OF SOCIOECONOMIC AND CLINICAL FACTORS ON TREATMENT ADHERENCE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASES PATIENT: FOCUS ON INHALATION THERAPY
Authors: SUBERNA BASNET  , YALLASAI VIJAYA DURGA  , SUNNY KUMAR YADAV  , SUBHI ADHIKARI  , SIJINA KS
Published: October 2024

Objective: Chronic obstructive pulmonary disease (COPD) refers to a persistent blockage of airflow that requires bronchodilator medication for the rest of one’s life. The goal of the treatment can only be met when the patient is adhering to the prescribed medicine. This study identifies and analyzes how clinical and socioeconomic factors affect COPD patients’ drug adherence to given therapy. The impact of our findings will reduce socioeconomic inequality in COPD management which will improve adherence to drugs and overall physical well-being.
Methods: The hospital-based cross-sectional studies were conducted at the Department of TB and CD for 6 months in a tertiary care hospital. A total of 55 patients diagnosed with COPD participated in the study after signing the informed constant. The individual patients were interviewed using MMAS-8 and Kuppuswamy scale questionnaires. The data were analyzed by Chi-square test to determine the correlation between medication adherence and socioeconomic status in patients with COPD.
Results: Among 55 COPD patients included in the study, their mean age was 62.2(+10.76) years. Out of the total participants: Significant associations between the medication adherence scale (MMRS-8) scores and the Kuppuswamy scale were found as p<0.0001, indicating that medication adherence was influenced by the patient’s socioeconomic status. In addition, the BORG scale which is used to measure exercise tolerance in COPD that found to have a significant correlation with an MMAS-8 score of p=0.03.
Conclusion: Our study found that a person with low socioeconomic levels will have poor adherence to inhaler therapy, leading to poor health outcomes like exacerbation and low physical activity due to shortness of breath.
A PROSPECTIVE OBSERVATIONAL STUDY OF MONITORING AND REPORTING OF ANTIMICROBIAL DRUGS ASSOCIATED ADVERSE DRUG REACTIONS AND THEIR SIGNIFICANCE ON PATIENTS SAFETY AND HEALTH-CARE OUTCOMES
Authors: ZEENATH UNNISSA  , MAHER UNISSA  , SHAISTA KHAN  , NAZIYA THASLEEM  , NIKHATH FATIMA
Published: October 2024

Objective: Adverse drug reaction (ADR) surveillance and reporting practices are at an early stage of development within the Indian context. The pharmacovigilance rate in India falls below 1%, which is notably lower compared to the global average of 5%. India holds the position of being the fourth most significant contributor to the pharmaceutical industry worldwide. Therefore, there exists a pressing demand to enhance the pharmacovigilance framework for safeguarding the health of the Indian population. ADR is defined as the unintended, obnoxious, and unwanted reaction due to the use of a drug. The administration of antimicrobial agents causes various ADR that has been analyzed throughout the study. The main objective of the research is to monitor and report the adverse drug reaction caused by antimicrobial drugs
Methods: A prospective observational study was carried out in the various departments of the hospital with duration of 3 months including 100 patients using patient profile form and ADR reporting forms and analyzing with the scales for causality, severity, and preventability assessment.
Results: During the study, 29 ADRs were found among 100 patients, with an incidence rate of 9.6%, more common in females (52%) than in males (48%). ADRs were most frequently reported in the age group of 35–51 years (34%), then 18–34 years (28%), and 1–17 years (24%). The general medicine department reported the highest number of ADRs (66%), followed by the pediatric department (24%). Cephalosporins caused the most ADRs (35%). Common ADRs included constipation, diarrhea (34%) and rashes, nausea, and vomiting (34%). Naranjo scale indicated that the causality of ADRs was probable (52%). Hartwig severity scale showed 55% ADRS to be mild. Schumock and Thornton method found that 76% of ADRs were preventable.Management of most of ADRs included drug withdrawal (52%).
Conclusion: The majority of cephalosporin-related side effects, which included constipation, diarrhoea, and rashes, were observed. Most of the patients got better with the help of ADR monitoring and management. Finding and treating drug-related problems early make patients feel better and keep them safe. This study shows health-care system why it is important to monitor and report ADR caused by drugs.
ANALYZING THE RELATIONSHIP AMONG CLINICAL SYMPTOMS, X-RAY RESULTS, AND CARTILAGE WEAR PATTERNS IN KNEE OSTEOARTHRITIS USING T2 MAPPING MRI
Authors: CHUNCHESH MD  , VANI AHUJA  , SUNIL SANTHOSH G  , BHARGAV G
Published: October 2024

Objectives: Osteoarthritis (OA) is a condition that causes joint pain, varying degrees of functional limitations, and a decrease in overall quality of life. The purpose of this study was to examine the progression of cartilage degeneration in knees affected by symptomatic OA and determine its relationship with X-ray and T2 map MRI findings.
Methods: This study was conducted at a Tertiary Care Teaching Institute in India and involved 40 patients. It was an observational type of study. For our assessment, we utilized the Western Ontario and McMaster University (WOMAC) osteoarthrosis index to evaluate function, quality of life, and joint pain. Medical imaging technique A standing AP view of the affected knee joint was taken using plain radiographs. Once the X-rays were obtained, they were graded using the Kellgren–Lawrence Classification, which ranges from 0 to 4 grades.
Results: Out of the total patients, 6.0% were <40 years old, 21.2% were between 41 and 50 years old, 27.2% were between 51 and 60 years old, 39.3% were between 61 and 70 years old, and 6.0% were above 70 years old. In this study, there were 21 females (63.6%) and 12 males (36.4%). In this study, the researchers found that there was no distinction between the sides of the limb affected. Both the left and right sides were involved in 13 cases each, accounting for 39.39% of the total cases. In addition, 7 cases, or 21.21%, reported experiencing bilateral knee pain. Merchant grade reported that out of the knees examined, 17.5% had Grade 0, 45% had Grade 1, 27.5% had Grade 2, 10% had Grade 3, and none had Grade 4.
Conclusion: The findings of this study suggest that T2 map MRI has the ability to accurately measure abnormal cartilage changes in conditions that affect the mechanical properties of the knee joint. It is crucial to have non-invasive methods that can assess early cartilage matrix changes. These methods are important for initiating early treatment, monitoring disease progression, planning operative procedures, and following up on operative cartilage repair.
ANALYSIS OF CD10 EXPRESSION IN PROSTATE ADENOCARCINOMA AND ITS CORRELATION WITH DIFFERENT CLINICOPATHOLOGICAL PARAMETERS AT RNTMC, UDAIPUR
Authors: NAVED KHAN  , NAMITA GOYAL  , ABHILASHA
Published: October 2024

Objective: The study aimed to analyze the expression of CD10 in prostate adenocarcinoma to aid in early diagnosis and anti-CD10 targeted therapy.
Methods: This was a cross-sectional study conducted in the Histopathology section of the Department of Pathologyat RNTMC, Udaipur, after approval from the ethical committee and institutional review board. This study was conducted on 92 patients suspected to have prostate cancer. The cases were assessed for Gleason score, Gleason Grade, and Serum Prostate Specific Antigen (PSA) levels. We performed IHC detection of CD10 in prostatic specimens and correlated the various patterns of CD10 expression concerning histopathological diagnosis.
Results: In our study, we found membranous expression in low-grade carcinomas with low Gleason score and grade. The high-grade carcinomas with high Gleason score and Grade predominantly showed cytoplasmic expression. The increased CD10 cytoplasmic expression was correlated with serum PSA level.
Conclusion: In our study, CD10 was found to be relevant. The low-grade carcinomas showed membranous positivity and high-grade carcinomas showed cytoplasmic expression. One hypothesis states that cytoplasmic expression is due to the localization of CD10 in the cytoplasm. Our study favors this hypothesis as there is cytoplasmic expression in high-grade tumors. In the future, this could be used as a diagnostic marker.