bluuebunny/crossref_metadata_2025 huggingface dataset:
LRP1 and RAGE Genes Transporting Amyloid and Tau Protein in the Hippocampal CA3 Area in an Ischemic Model of Alzheimer’s Disease with 2-Year Survival
Authors: Pluta Ryszard , Kocki Janusz , Bogucki Jacek , Bogucka-Kocka Anna , Czuczwar Stanisław J.
Published: December 2023

Explaining changes at the gene level that occur during neurodegeneration in the CA3 area is crucial from the point of view of memory impairment and the development of post-ischemic dementia. An ischemic model of Alzheimer’s disease was used to evaluate changes in the expression of genes related to amyloid transport in the CA3 region of the hippocampus after 10 min of brain ischemia with survival of 2, 7 and 30 days and 12, 18 and 24 months. The quantitative reverse transcriptase PCR assay revealed that the expression of the LRP1 and RAGE genes involved in amyloid transport was dysregulated from 2 days to 24 months post-ischemia in the CA3 area of the hippocampus. LRP1 gene expression 2 and 7 days after ischemia was below control values. However, its expression from day 30 to 24 months, survival after an ischemic episode was above control values. RAGE gene expression 2 days after ischemia was below control values, reaching a maximum increase 7 and 30 days post-ischemia. Then, after 12, 18 and 24 months, it was again below the control values. The data indicate that in the CA3 area of the hippocampus, an episode of brain ischemia causes the increased expression of the RAGE gene for 7–30 days during the acute phase and that of LRP1 from 1 to 24 months after ischemia during the chronic stage. In other words, in the early post-ischemic stage, the expression of the gene that transport amyloid to the brain increases (7–30 days). Conversely, in the late post-ischemic stage, amyloid scavenging/cleaning gene activity increases, reducing and/or preventing further neuronal damage or facilitating the healing of damaged sites. This is how the new phenomenon of pyramidal neuronal damage in the CA3 area after ischemia is defined. In summary, post-ischemic modification of the LRP1 and RAGE genes is useful in the study of the ischemic pathways and molecular factors involved in the development of Alzheimer’s disease.
Contemporaneous Perioperative Inflammatory and Angiogenic Cytokine Profiles of Surgical Breast, Colorectal, and Prostate Cancer Patients: Clinical Implications
Authors: Baghaie Leili , Haxho Fiona , Leroy Fleur , Lewis Beth , Wawer Alexander , Minhas Shamano , Harless William W. , Szewczuk Myron R.
Published: December 2023

Surgery-induced tumor growth acceleration and synchronous metastatic growth promotion have been observed for decades. Surgery-induced wound healing, orchestrated through growth factors, chemokines, and cytokines, can negatively impact patients harboring residual or metastatic disease. We provide detailed clinical evidence of this process in surgical breast, prostate, and colorectal cancer patients. Plasma samples were analyzed from 68 cancer patients who had not received treatment before surgery or adjuvant therapy until at least four weeks post-surgery. The levels of plasma cytokines, chemokines, and growth factors were simultaneously quantified and profiled using multiplexed immunoassays for eight time points sampled per patient. The immunologic processes are induced immediately after surgery in patients, characterized by a drastic short-term shift in the expression levels of pro-inflammatory and angiogenic molecules and cytokines. A rapid and significant spike in circulating plasma levels of hepatocyte growth factor (HGF), interleukin-6 (IL-6), placental growth factor (PLGF), and matrix metalloproteinase-9 (MMP-9) after surgery was noted. The rise in these molecules was concomitant with a significant drop in transforming growth factor-β1 (TGF-β1), platelet-derived growth factor (PDGF-AB/BB), insulin-like growth factor-1 (IGF-1), and monocyte chemoattractant protein-2 (MCP-2). If not earlier, each plasma analyte was normalized to baseline levels within 1–2 weeks after surgery, suggesting that surgical intervention alone was responsible for these effects. The effects of surgical tumor removal on disrupting the pro-inflammatory and angiogenic plasma profiles of cancer patients provide evidence for potentiating malignant progression. Our findings indicate a narrow therapeutic window of opportunity after surgery to prevent disease recurrence.
Relationship between Bullying and the Type of Physical Activity Practised by Spanish Pre- and Adolescents
Authors: Benítez-Sillero Juan de Dios , Murillo-Moraño Javier , Corredor-Corredor Diego , Morente-Montero Álvaro , Branquinho Luís , Armada-Crespo José Manuel
Published: December 2023

Background: The influence of bullying on physical activity beyond school time is uncertain, as it can vary widely in terms of type, modality, duration, adult supervision, and objectives. Methods: This study aims to analyze the relationship between school bullying and the type of physical activity practised. To this end, a descriptive study was made of 2025 pre- and adolescents aged between 10 and 19 years, reporting on their participation in victimisation and perpetration. The EBIPQ and PAQ-A were used. An analysis of the relationships between these variables was carried out according to gender and type of activity practised. Results: The results showed a higher rate of victimisation in boys who did not practise physical activity. Meanwhile, perpetration was higher in those who practised organised physical activity, especially in boys. Depending on the type of physical activity, the higher levels of both victimisation and perpetration of those who practised wrestling activities stand out in comparison with other groups. Conclusions: It could be stated that physical activity may be a protective factor against bullying victimisation, especially in boys. However, participation in organised physical activity activities may be related to higher perpetration in this sample in adolescent boys.
Interstitial Lung Disease Is Associated with Sleep Disorders in Rheumatoid Arthritis Patients
Authors: Mena-Vázquez Natalia , Redondo-Rodriguez Rocío , Cabezudo-García Pablo , Garcia-Studer Aimara , Ortiz-Márquez Fernando , Borregón-Garrido Paula , Martín-Valverde Manuel , Ureña-Garnica Inmaculada , Manrique-Arija Sara , Cano-García Laura , Fernández-Nebro Antonio
Published: December 2023

Objective: To evaluate sleep disorders and associated factors in patients with rheumatoid-arthritis-associated interstitial lung disease (RA-ILD). Methods: We performed an observational study of 35 patients with RA-ILD (cases) and 35 age- and sex-matched RA patients without ILD (controls). We evaluated sleep disorders (Oviedo Sleep Questionnaire), positive psychological factors (resilience using the Wagnild and Young Resilience Scale, emotional intelligence using the 24-item Trait Meta-Mood Scale), anxiety and depression (Hospital Anxiety and Depression Scale), quality of life (36-item short-form survey), and fatigue (Functional Assessment of Chronic Illness Therapy Questionnaire). Other variables studied included the Charlson Comorbidity Index (CCI) and RA activity according to the DAS28-ESR. Results: Compared to the controls, the cases were characterized by poorer sleep quality with a higher prevalence of insomnia (42% vs. 20%; p = 0.039), greater severity of insomnia (p = 0.001), and lower sleep satisfaction (p = 0.033). They also had poorer resilience and emotional recovery and more severe anxiety and depression. A diagnosis of ILD was the only factor independently associated with the three dimensions of sleep quality. The predictors of poorer sleep satisfaction in patients with RA-ILD were age (β = −0.379), DAS28-ESR (β = −0.331), and usual interstitial pneumonia pattern (β = −0.438). The predictors of insomnia were DAS28-ESR (β = 0.294), resilience (β = −0.352), and CCI (β = 0.377). Conclusions: RA-ILD is associated with significant sleep disorders. RA-ILD seems to be an independent risk factor for sleep alterations, with a greater impact on insomnia. Age, disease activity, and comorbidity also play a role in sleep disorders in patients with RA-ILD.
Navigating a Complex Intersection: Immunotherapy and Radiotherapy Synergy in Squamous Cell Carcinoma of the Skin—A Comprehensive Literature Review
Authors: Georgescu Mihai Teodor , Trifanescu Oana Gabriela , Serbanescu Georgia Luiza , Mitrica Radu Iulian , Georgescu Dragos Eugen , Mihaila Raluca Ioana , Neagu Alexandra , Gaube Alexandra , Botezatu Cristian , Manolescu Mastalier Bogdan Stelian
Published: December 2023

Skin squamous cell carcinoma (SCC) represents a major public health concern due to its high incidence and potential for local invasion and metastasis. Compared to local recurrence, metastatic SCC represents an even greater therapeutic challenge. Once distant metastasis occurs, the disease becomes incurable, and treatment focuses on palliation and prolonging survival. The immune microenvironment of SCC is characterized by an infiltration of immune cells, including tumor-infiltrating lymphocytes. In addition to its direct cytotoxic effects, radiotherapy also induces immunomodulatory effects within the tumor microenvironment. Radiation can promote the release of tumor-associated antigens and induce immunogenic cell death, thereby enhancing the recognition of tumor cells by the immune system. Immunotherapy and radiotherapy have emerged as promising therapeutic modalities for metastatic SCC. This literature review aims to evaluate the potential synergy between these treatments and shed light on their combined efficacy. Within the manuscript, we present a compelling case report of a patient with advanced SCC who exhibited resistance to the combined regimen of immunotherapy and radiotherapy, leading to disease progression. Despite the increasing evidence supporting the synergy between these modalities, this case underscores the complex nature of treatment response and the importance of considering individual patient characteristics.
Analyzing County-Level COVID-19 Vaccination Rates in Texas: A New Lindley Regression Model
Authors: da Costa Nicollas S. S. , de Lima Maria do Carmo S. , Cordeiro Gauss M.
Published: December 2023

This work aims to study the factors that explain the COVID-19 vaccination rate through a generalized odd log-logistic Lindley regression model with a shape systematic component. To accomplish this, a dataset of the vaccination rate of 254 counties in the state of Texas, US, was used, and simulations were performed to investigate the accuracy of the maximum likelihood estimators in the proposed regression model. The mathematical properties investigated provide important information about the characteristics of the distribution. Diagnostic analysis and deviance residuals are addressed to examine the fit of the model. The proposed model shows effectiveness in identifying the key variables of COVID-19 vaccination rates at the county level, which can contribute to improving vaccination campaigns. Moreover, the findings corroborate with prior studies, and the new distribution is a suitable alternative model for future works on different datasets.
Exploring Huntington’s Disease Diagnosis via Artificial Intelligence Models: A Comprehensive Review
Authors: Ganesh Sowmiyalakshmi , Chithambaram Thillai , Krishnan Nadesh Ramu , Vincent Durai Raj , Kaliappan Jayakumar , Srinivasan Kathiravan
Published: December 2023

Huntington’s Disease (HD) is a devastating neurodegenerative disorder characterized by progressive motor dysfunction, cognitive impairment, and psychiatric symptoms. The early and accurate diagnosis of HD is crucial for effective intervention and patient care. This comprehensive review provides a comprehensive overview of the utilization of Artificial Intelligence (AI) powered algorithms in the diagnosis of HD. This review systematically analyses the existing literature to identify key trends, methodologies, and challenges in this emerging field. It also highlights the potential of ML and DL approaches in automating HD diagnosis through the analysis of clinical, genetic, and neuroimaging data. This review also discusses the limitations and ethical considerations associated with these models and suggests future research directions aimed at improving the early detection and management of Huntington’s disease. It also serves as a valuable resource for researchers, clinicians, and healthcare professionals interested in the intersection of machine learning and neurodegenerative disease diagnosis.
The Associations between the Maxillary Sinus Volume, Infraorbital Ethmoid Cells, and the Infraorbital Canal: A CT-Based Study
Authors: Kedar Einat , Koren Ilan , Medlej Bahaa , Hershkovitz Israel
Published: December 2023

This CT-based study aimed to characterize and explain the existence of two anatomical structures positioned near the maxillary sinuses, which are of clinical relevance in rhinology and maxillofacial surgery. A total of 182 head scans (92 males and 90 females) were inspected for infraorbital ethmoid cells (IECs) and for the type (route) of infraorbital canal (IOC). The maxillary sinuses were segmented, and their volumes were measured. Statistical analysis was conducted to reveal the associations between the two anatomical variations, namely, sex and the maxillary sinus volume. Infraorbital ethmoid cells were noted in 43.9% of the individuals studied; they were more frequent in males (53.3%) than in females (34.4%). The descending infraorbital nerve (type 3 IOC) was found in 13.2% of individuals and was independent of sex. Infraorbital ethmoid cells were associated with the IOC types. The maxillary sinus volume was found to be sex-dependent. A large sinus volume is significantly associated with IOC Type 3 (the descending canal) and the presence of IEC. Dentists, radiologists, and surgeons should be aware that individuals with extensive pneumatization of the maxillary sinuses are more likely to display a descending IOC and IEC. These findings should be studied, along with CT scans, before treatment and surgery.
Diagnosis of Eosinophilic Otitis Media Using Blood Eosinophil Levels
Authors: Jeong Yeonsu , Na Gina , Ha Jong-Gyun , Kim Dachan , Kim Junyup , Bae Seonghoon
Published: December 2023

Eosinophilic otitis media (EOM) is a rare middle ear disease with unfavorable outcomes. Under the current diagnostic criteria of EOM, it is challenging to suspect EOM before tympanostomy. Therefore, this study attempted to use blood eosinophil levels for the differential diagnosis of EOM from other conditions. Three disease groups with features of recurrent otorrhea were categorized, which included the following: EOM (n = 9), granulomatosis with polyangiitis (GPA, n = 12), and primary ciliary dyskinesia (PCD, n = 6). Clinical and radiological characteristics were analyzed in the three groups. Patients who underwent ventilation tube insertion due to serous otitis media were enrolled as the control group (n = 225) to evaluate the diagnostic validity of blood eosinophilia. The EOM group showed a significantly higher blood eosinophil concentration (p < 0.001) and blood eosinophil count (p < 0.001) compared to the GPA and PCD groups. The estimated sensitivity and specificity for diagnosing EOM from OME patients who underwent ventilation tube insertion were 100% and 95.6%, respectively. In addition, EOM tended to have protympanic space soft tissue density and a relatively clear retrotympanic space in temporal bone computerized tomography. Blood eosinophil evaluation is a significant clinical indicator of EOM. Furthermore, the assessment of exclusive protympanic soft tissue density can provide an additional diagnostic clue.
Oligodontia in the Clinical Spectrum of Syndromes: A Systematic Review
Authors: Castilho Natália Lopes , Resende Kêmelly Karolliny Moreira , Santos Juliana Amorim dos , Machado Renato Assis , Coletta Ricardo D. , Guerra Eliete Neves Silva , Acevedo Ana Carolina , Martelli-Junior Hercílio
Published: December 2023

The aim of this systematic review was to describe the clinical and genetic features of syndromes showing oligodontia as a sign. The review was performed according to the PRISMA 2020 checklist guidelines, and the search was conducted using PubMed, Scopus, Lilacs, Web of science, Livivo, and EMBASE and supplemented by a gray literature search on Google Scholar and ProQuest, applying key terms relevant to the research questions. The systematic review identified 47 types of syndromes in 83 studies, and the most common was hypohidrotic ectodermal dysplasia, which was reported in 24 patients in 22 studies. Other common syndromes that reported oligodontia included Axenfeld–Rieger syndrome, Witkop’s syndrome, Ellis–van Creveld syndrome, blepharocheilodontic syndrome, and oculofaciocardiodental syndrome. The X-linked mode of inheritance was the most reported (n = 13 studies), followed by the autosomal dominant (n = 13 studies). The review describes the main syndromes that may have oligodontia as a clinical sign and reinforces the need for orodental–facial examining for adequate diagnosis and treatment of the affected patients. Molecular analysis in order to better understand the occurrence of oligodontia is imperative.
On the Construct of Functional Psychology’s Developmental Theory: Basic Experiences of the Self (BEsS)
Authors: Dipasquale Filippo , Blandini Marta , Gueli Raffaele , Fecarotta Paola , Magnano Paola
Published: December 2023

According to the neo-functional developmental theory, newborns and infants exhibit complex psycho-bodily functioning. The Basic Experiences of the Self (BEsS) refer to how they fulfil their essential life needs by organising their psycho-bodily functions in a typical configuration. As part of our research study, we developed a prototype psychometric tool called the BEsS Assessment Form (BAF) to assess the BEsS in infants aged zero to three years. We collected video recordings of their spontaneous behaviour and used the BAF to evaluate function polarity. In the BAF, thirty pairs of words represent functions in their dyadic polarity. To estimate the level of function polarity, we used the Osgood semantic differential scale, which ranges from seven to one. The study’s results confirm that functions can be assessed by grading along the opposite polarity spectrum. Moreover, in accordance with the theory, the functions can be grouped into four domains: the emotional, postural motor, physiological, and cognitive-symbolic planes. Our findings suggest that the characteristics of BEsS are significantly influenced by the activation of the physiological and postural motor functions, which are related to the early regulation of the autonomic nervous system and can be used to evaluate infant arousal.
“Canalvoltaico” in Emilia-Romagna, Italy: Assessing Technical, Economic, and Environmental Feasibility of Suspended Photovoltaic Panels over Water Canals
Authors: Solfrini Valentino , Farneti Riccardo , Rossi Jessica , Bianchini Augusto , Morolli Matteo , Savini Ivan
Published: December 2023

Solar energy has become an increasingly important part of the global energy mix. In Italy, the photovoltaic power installed has grown by 40% since 2015, which raises the issue of land use and occupation. A viable alternative, already experienced in India, is placing solar panels on the top of water canals (Canal-Top—in Italian, “Canalvoltaico”). It is a relatively new and innovative approach to solar energy installation that offers several advantages including the potential to generate renewable energy without occupying additional land, reduce water evaporation from canals, and improve water quality by reducing algae growth. The article explores various Canal-Top solar projects over the world; then, a feasible application in the Italian region “Emilia-Romagna” is discussed, evaluating two potential construction designs. The primary aim is to establish a capital expenditure cost framework, offering reference values currently lacking in the extant literature and industry studies pertaining to Italy. Moreover, the study addresses additional key factors, including water savings, maintenance considerations, and safety implications.
Review of Hot Topics in the Sustainable Development of Energy, Water, and Environment Systems Conference in 2022
Authors: Chu Wenxiao , Vicidomini Maria , Calise Francesco , Duić Neven , Østergaard Poul Alberg , Wang Qiuwang , da Graça Carvalho Maria
Published: December 2023

The current applications in the energy sector are based largely on fossil fuels which release greenhouse gas emissions to the atmosphere. To face the issue of global warming, the energy sector has to transfer to and develop sustainable energy solutions that do not release carbon emissions. This is one of the primary motivators for the SDEWES conference as well as for this review, and previous ones, examining the most recent works based on sustainable and green energy production in such fields. The 17th Conference on the Sustainable Development of Energy, Water, and Environment Systems (SDEWES) was held on 6–10 November 2022 in Paphos, Cyprus. The SDEWES conference aims at solving complex and ongoing concerns that approach a long-term perspective and supporting innovative solutions and continuous monitoring and evaluation. This review paper aims at collecting the main presented papers focused on the following hot topics: low-carbon technologies based on renewable and clean-energy systems, including mainly biomass, solar, and wind energy applications; energy storage systems; hydrogen-based systems; energy-saving strategies in buildings; and the adoption of smart management strategies using renewable energy systems. These topics are investigated in order to propose solutions to address the issues of climate change, water scarcity, and energy saving. From the analyzed works, we note that some key issues for sustainable development remain to be further addressed: such as novel and advanced energy storage systems, green hydrogen production, novel low-temperature district heating and cooling networks, novel solar technologies for the simultaneous production of power and high temperature heat, solar desalination for hydrogen production systems, and agrivoltaic systems for the production of power and food.
Evidence-Based Policymaking: Insights and Recommendations for the Implementation of Clean Energy Transition Pathways for Kenya’s Power Sector
Authors: Fields Neve , Ryves David , Yeganyan Rudolf , Cannone Carla , Tan Naomi , Howells Mark
Published: December 2023

With ambitious targets to drastically increase economic activity over the next decade, Kenya’s future is undoubtedly energy-intensive. Current power capacity expansion plans will see Kenya considerably ramp up fossil fuel generation, significantly increasing emissions. Therefore, Kenya is at a crucial stage of its national development, with critical decisions to make regarding its future power expansion and production. OSeMOSYS modelling software (clicSAND version v1.1) is employed to produce a series of possible clean energy transition pathways to increase renewable power production under rapidly intensifying demand. This study integrates existing national priorities and policies into six modelled scenarios to provide insights into their generation, total production, and costs, which can assist future policymaking and capacity-building efforts. The high-level insights gained in this research were employed to suggest key recommendations for Kenya’s power sector. Most notably, policy alignment, increased wind power production, energy-efficiency penetration, finance and investment securement, the development of storage technologies, power transmission, and distribution improvements should be prioritised.
Effect of Sand and Dust Shading on the Output Characteristics of Solar Photovoltaic Modules in Desertification Areas
Authors: Zhao Mingzhi , Yu Rong , Chang Chun , Bao Daorina , Mei Aohan , Liu Yingjie , Wang Ningbo
Published: December 2023

Photovoltaic power generation is rapidly developing as a kind of renewable energy that can protect the ecological environment. The establishment of photovoltaic power stations in desertification areas can play a very important role in desert windbreaks and sand fixation as well as improve the ecological environment. The realization of the effective integration of photovoltaics and deserts can have multiple benefits for the economy, society, and ecology. However, the deposition of sand and dust caused by environmental factors in desertification areas can seriously affect the power generation efficiency of PV modules. In this study, the output characteristics of photovoltaic modules were tested under three wind speed conditions (5 m/s, 10 m/s, and 15 m/s), with different sand densities, sand particle sizes, and inclination angles. The experimental study showed that the module’s output power gradually decreased with an increase in the density of accumulated sand; the sand accumulation density on the surface of the photovoltaic module increased from 0 to 40 g/m2, and the maximum output power decreased by 32.2%. As the sand particle size increased, the maximum output power of the module rose and was gradually stabilized in the three wind speed groups. As the sand particle size increased, the maximum output power of the module increased and gradually stabilized in the three wind speed groups. When the wind speed was 15 m/s, the component output power of the angle had the largest drop; the tilt angle was 60° when the relative output power rate reached the minimum (i.e., 86.5%); that is, there was electrical energy loss of approximately 13.7%. The sand particle size and accumulated sand density were the control variables related to the module temperature and the transmittance of the proportion of the impact of the module filling factor differences. According to the curve analysis of the filling factor in different sand accumulation densities, the filling factor first increased and then decreased. In this test, the filling factor at the sand accumulation density of 35 g/m2 (module temperature valley) reached the peak value. The change trend for the component filling factor under different sand particle sizes fluctuated.
Measuring and Modeling the Skin Effect for Harmonic Power Flow Studies
Authors: Silvério Eduardo Tavares , Macedo Junior Jose Rubens
Published: December 2023

This research aims to quantify the skin effect and estimate expressions that well represent the phenomenon for harmonic power flow studies. The primary focus is to validate the behavior of the skin effect at harmonic frequencies ranging from 60 Hz to 960 Hz, while considering various amplitudes of electric current. The investigation not only examines the measurement of the skin effect, but also considers the temperature of the tested conductors, aiming to analyze the increase in resistance resulting from temperature rise and resistivity changes. The measurement outcomes demonstrate notable increments in electrical resistance, with resistivity increases of up to 1.9% observed throughout the measurement process. Finally, based on the results obtained through laboratory measurements, mathematical expressions were estimated as a function of frequency. In order to evaluate the simulation time reduction by the proposed expressions, OpenDSS (version: 9.4.1.2; Electric Power Research Institute, Knoxville, TN, USA) software was used, which aims at quantifying the impact of the skin effect on the technical losses. The results from these simulations demonstrate that the proposed expressions to account for the skin effect in conductors reduce the simulation time by around 17% for harmonic power flow.
Fault Detection on Power Transmission Line Based on Wavelet Transform and Scalogram Image Analysis
Authors: Altaie Ahmed Sabri , Majeed Ammar Abbas , Abderrahim Mohamed , Alkhazraji Afaneen
Published: December 2023

Given the massive increase in demand for electrical energy, particularly owing to global climate change and population expansion, as well as the development of complicated electrical systems due to the urgent need for a sophisticated component to enhance power delivery, it becomes important to adopt a smart and contemporary approach that is also appropriate for the aim of protecting transmission lines (TLs) and ensuring the continuous delivery of electric power to customers. Consequently, a unique and highly reliable approach for identifying faults in TLs is presented in this work, which employs Wavelet Transform and is evaluated using Matlab simulation. Wavelets of various kinds were utilized to demonstrate their dependability. Furthermore, utilizing this approach has shown itself to be highly successful and has yielded spectacular results even when it is used on a complicated electrical network. Moreover, many types of faults were presented and afterward evaluated and verified for the network in various settings, which also demonstrated their potential to recognize faults within a relatively short space of time. This innovation will alter the idea of fault detection by providing a complete and integrated model for detecting faults in a TL, and it may be regarded as a revolution in the renewal of core principles in TL protection.
Effects of Afforestation Patterns on Soil Nutrient and Microbial Community Diversity in Rocky Desertification Areas
Authors: Liu Liling , He Ting , Zhu Ninghua , Peng Yuanying , Gao Xiaoqian , Liu Zongxin , Dang Peng
Published: December 2023

Karst ecosystems are characterized by the dissolution of soluble rocks, displaying distinctive landscape features such as rugged peaks, steep slopes, and deep valleys. Afforestation is an effective approach for improving soil quality in rocky desertification areas because plants have evolved unique adaptations to thrive in such environments. However, the effects of tree species composition and cultivation patterns on the soil quality, microbial diversity, stability, and functions in rocky desertification areas remain unclear. In this work, four study plots including three types of forests—pure Pinus massoniana plantations, Toona sinensis plantations, mixed coniferous and broadleaf plantations (Pinus massoniana–Betula luminifera forests), and unforested area as the control—were established in a karst desertification area in the Hunan province of China. Soil properties including soil bulk density, soil organic carbon, total nitrogen, total phosphate, soil ammonium nitrogen, nitrate, available phosphate, soil pH, and soil microbial diversity were investigated in the study area. The results showed that the forests significantly increased the soil organic carbon, total nitrogen, and ammonium nitrogen compared to the unforested area. The microbial diversity indicators in mixed forests were significantly higher than those in the Pinus massoniana forests. The dominant bacteria phyla included Proteobacteria, Acidobacteria, and Actinobacteria, while fungi species such as Ascomycota and Basidiomycota were identified in all study plots. In addition, the AVD index evaluation revealed that the mixed forests enhanced the stability of the soil microbial communities compared to the monoculture plantations and unforested plots in rocky desertification areas. The research results indicated that, among the various forest types, the mixed forest was the most effective choice for afforestation in terms of improving the soil quality by changing the soil’s physiological properties in rocky desertification areas. Our study provided guidance and insights for afforestation technology and the optimal allocation of different tree species in the cultivation and management of plantation forests in rocky desertification regions.
The Influence of Biofuels Addition on Shock-Induced Ignition and Combustion of Methane–Hydrogen Mixtures
Authors: Drakon Alexander , Eremin Alexander
Published: December 2023

The ignition and combustion of three-component methane–hydrogen biofuel mixtures, considered as prospective fuels, were experimentally and numerically studied. Ignition delays in argon-diluted methane–hydrogen mixtures partially substituted with methanol or dimethyl ether were measured behind reflected shock waves in a temperature range of 1050–1900 K at pressures of 3.5–5.5 bar. The obtained results were used for validation of modern kinetic mechanisms for hydrocarbons combustion. Numerical modeling of the combustion of the considered fuels in air at elevated pressures and temperatures was carried out, simulating typical engine compressed conditions, and the dependencies of key parameters such as flame velocity and temperature on fuel composition were obtained. The results of the study can be used in developing new energy technologies, reducing the environmental impact of hydrocarbon combustion.
New Insight into the Effects of Gaseous CO2 on Spherically Symmetric Droplet Flames
Authors: Hong Ter-Ki , Park Seul-Hyun
Published: December 2023

This study investigated the effect of CO2 on the burning behavior and radiative properties of a single ethanol droplet flame in microgravity. Measurements of the droplet burning rate, the flame size and temperature, and the radiative emissions were performed, under microgravity conditions for ethanol droplets burning in N2 and CO2 environments, using the 1.5 s drop tower facilities at the Korea Maritime and Ocean University (KMOU). The non-monotonic sooting behaviors (caused by the elevated O2 concentrations) were found to have a significant influence on radiative heat losses in N2 environments, resulting in non-linear droplet burning behaviors with O2 concentrations. Due to the unique nature of CO2 in microgravity, which absorbs radiative energy from the flame and raises the temperatures of the surrounding gases, the CO2 environments suppressed the radiative heat losses from the flame, regardless of the non-monotonic sooting behavior observed at the higher O2 concentrations. These experimental findings highlight the complicated physics of CO2 gas radiation in microgravity, which has not been quantitatively explored.
Identification and Characterization of the Stimulator of Interferon Genes (STING) in Chinese Giant Salamander Andrias davidianus
Authors: Chen Zhongyuan , Wang Ronghua , Wang Ruisong , Yu Naitong , Yang Pinhong
Published: December 2023

The stimulator of interferon genes (STING) is a central and multifaceted mediator in innate immunity, and plays vital roles in defending against pathogen infection. In this study, we identified and functionally characterized the STING homolog from the Chinese giant salamander Andrias davidianus (AdSTING) for the first time. The open reading frame of AdSTING encodes a 362 amino acid protein with a predicted molecular mass of 41.6 kDa, which shares 31.1–46.7% of its sequence identity with STING homologs in other vertebrates. Structural analysis revealed that AdSTING possesses four predicted transmembrane domains (TMs) at the N-terminal, and a C-terminal domain (CTD) featuring a dimerization domain (DD), a c-di-GMP-binding domain (CBD), and a short C-terminal tail (CTT). Tissue distribution analysis showed that AdSTING mRNA was ubiquitously expressed in all examined tissues, with abundant expression in muscles, intestine, and thymus. During Andrias davidianus ranavirus (ADRV) infection, significant up-regulation of AdSTING expression was observed in the thymus, spleen, and kidney. Upon different stimuli in vitro, the expression of AdSTING was significantly induced by ADRV infection or polyinosin-polycytidylic acid (poly I:C) stimulation, but no obvious changes were observed during lipopolysaccharide (LPS) stimulation. Subcellular localization analysis revealed that AdSTING mainly localized in the cytoplasm in the Chinese giant salamander thymus cell line (GSTC) and co-localized with the endoplasmic reticulum (ER). Luciferase reporter assays confirmed the ability of AdSTING to activate the interferon-stimulated response element (ISRE) and interferon (IFN) promoter. Furthermore, overexpression of AdSTING effectively decreased ADRV infection, as evidenced by the reduction of virus titers and viral gene expression. Collectively, our findings underscore the pivotal role of AdSTING in the antiviral innate immunity of the Chinese giant salamander, offering insights into the functional evolution of STING in amphibians.
Identification of Local Isotropic Turbulence Conditions in Various Bubble Columns Based on Several Reliable Parameters
Authors: Nedeltchev Stoyan
Published: December 2023

Bubble columns (BCs) are widely used in the chemical industry. In many industrial applications, these important gas-liquid contactors operate in a churn-turbulent flow regime. In principle, it is essential to determine the operating conditions in every BC reactor, in which local isotropic turbulence is established. In this work, it was demonstrated that several different parameters (Kolmogorov entropy, correlation dimension and novel hybrid index) follow a monotonic decreasing trend. This finding could be explained by the constantly increasing coalesced bubble size, which brings more order into the gas-liquid system and thus any entropic or chaotic parameter should decrease with the increase in the superficial gas velocity Ug. The profiles of the new parameters in various gas-liquid systems were studied. They were extracted from different pressure signals (gauge or absolute). In this research, BCs of different diameter and equipped with different gas distributors were used. It was demonstrated that the studied parameters could be successfully correlated with the length scale of the micro eddies and thus the Ug range of applicability of the local isotropic turbulence theory under various operating conditions was indirectly determined. The overall gas holdup profiles were analyzed and, based on the exponent of the Ug value, it was found that in the aqueous solutions of alcohols studied, the conditions in the bubble bed (BB) are homogeneous, whereas in the air-tap water system aerated in different BCs, the conditions in the BB are heterogeneous. This result implies that the local isotropic turbulence conditions predominate mainly around the corresponding measurement positions.
Effect of Medium Chain Triglycerides on the Digestion and Quality Characteristics of Tea Polyphenols-Fortified Cooked Rice
Authors: Li Ying , Niu Liya , Sun Chao , Li Dongming , Zeng Zicong , Xiao Jianhui
Published: December 2023

Nowadays, medium chain triglycerides (MCT) with special health benefits have been increasingly applied for fortifying food products. Therefore, the present work aimed to investigate the effects of MCT on traditional tea polyphenols-fortified cooked rice (TP-FCR). It was visualized by DSC, CLSM, XRD, FT-IR, and Raman spectroscopy. The higher content of starch-MCT complexes with an increase in the relative crystallinity and the generation of short-range ordered structures contributed to a more ordered and compact molecular arrangement, which can hinder the action of digestive enzymes on starch. SEM demonstrated that MCT transformed the microstructure of TP-FCR into a denser and firmer character, making it an essential component hindering the accessibility of digestive enzymes to starch granules and slowing the release of tea polyphenols in TP-FCR to attenuate starch digestion. Consequently, the addition of MCT reduced the polyphenol-regulated starch digestibility from 74.28% in cooked white rice to 64.43% in TP-FCR, and further down to 50.82%. Besides, MCT also reduced the adhesiveness and improved the whiteness of TP-FCR. The findings suggested that MCT incorporation could be a potential strategy in cooked rice production to achieve high sensory quality and low glycemic cooked rice.
Effect of Yogurt Ice Cream on the Viability and Antidiabetic Potential of the Probiotics Lactobacillus acidophilus, Lacticaseibacillus rhamnosus, and Bifidobacterium animalis subsp. lactis after In Vitro Digestion
Authors: Talearngkul Rinrada , Sae-tan Sudathip , Sirivarasai Jintana
Published: December 2023

Probiotics can ameliorate type 2 diabetes mellitus (T2DM) via several mechanisms such as by decreasing inflammatory cytokines and increasing pancreatic β-cell functions. Another targeted mechanism for managing T2DM involves inhibiting α-amylase and α-glucosidase, which exhibit antioxidant activity and affect carbohydrate metabolism by delaying carbohydrate digestion, thus mitigating glucose in the circulation. Dairy products are effective matrices for delivering probiotics through the gastrointestinal tract. We compared the viability and antioxidant activity of the probiotics Lactobacillus acidophilus LA-5, Lacticaseibacillus rhamnosus GG, and Bifidobacterium animalis subsp. lactis in yogurt ice cream after in vitro digestion and compared α-amylase and α-glucosidase inhibition activities. Lacticaseibacillus rhamnosus GG had the highest viability after in vitro digestion (oral, gastric, and intestinal). Lactobacillus acidophilus LA-5 and Lacticaseibacillus rhamnosus GG exhibited the highest percentages of α-glucosidase (16.37% ± 0.32%) and α-amylase (41.37% ± 0.61%) inhibition. Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus acidophilus LA-5 showed the highest antioxidant activities via the α,α-diphenyl-β-picrylhydrazyl free radical-scavenging method and ferric-reducing antioxidant power assay, respectively. These findings suggest that yogurt ice cream can provide a suitable matrix for the delivery of probiotics from dairy culture to promote intestinal homeostasis with probiotic benefits in the host as well as a potential functional food to help reduce postprandial hyperglycaemia.
Novel Environmentally Responsive Polyvinyl Polyamine Hydrogels Capable of Phase Transformation with Temperature for Applications in Reservoir Profile Control
Authors: Meng Jianxun , Mao Guoliang , Zhu Zhixuan , Li Qingsong , Lin Xuesong , Wang Lichao , Li Yiran , Huang Yue
Published: December 2023

Hydrogel has been widely used in reservoir regulation for enhancing oil recovery, however, this process can experience negative influences on the properties and effects of the hydrogels. Therefore, developing novel hydrogels with excellent environmental responsiveness would improve the formation adaptability of hydrogels. In this study, novel polyvinyl polyamine hydrogels were synthesized by a ring-opening addition reaction between polyvinyl polyamines and polyethylene glycol glycidyl ether. The results of atomic force microscopy and transmission electron microscopy showed that the polyvinyl polyamine gel had a porous and irregular bulk structure and was endowed with water storage. With the temperature rising from 30 °C to 60 °C, the transmittance of diethylenetriamine hydrogel decreased from 84.3% to 18.8%, indicating that a phase transition had occurred. After the polyvinyl polyamine hydrogel with low initial viscosity was injected into the formation in the liquid phase, the increase of the reservoir temperature caused it to turn into an elastomer, thereby migrating to the depth of the reservoir and achieving effective plugging. Polyvinyl polyamine hydrogel could improve the profile of heterogeneous layers significantly by forcing subsequent fluids into the low permeability zone in the form of elastomers in the medium temperature reservoirs of 40–60 °C. The novel environmentally responsive polyvinyl polyamine hydrogels, capable of phase transformation with temperature, exhibited superior performance in recovering residual oil, which was beneficial for applications in reservoir profile control and oilfield development.
The Advantages of Non-Adhesive Gel-like Embolic Materials in the Endovascular Treatment of Benign Hypervascularized Lesions of the Head and Neck
Authors: Petrov Andrey , Ivanov Arkady , Kolomin Egor , Tukanov Nikita , Petrova Anna , Rozhchenko Larisa , Suvorova Julia
Published: December 2023

Objectives: The use of non-adhesive gel-like embolic materials (NAGLEMs) in the endovascular treatment of hypervascularized formations in the head and neck is gaining in popularity because of a number of important characteristics involved. Their primary benefits are their capacity to penetrate diseased vasculature, effectively distribute, and, most importantly, remain controllable during the process. We reviewed the literature and evaluated the results of using NAGLEMs in comparison to other embolizing substances (namely, coils, glue, and particles) as alternative embolizing agents for patients receiving care at our clinic. The process comprised evaluating the safety, effectiveness, and technological elements of endovascular therapy used to treat two categories of hypervascular pathological abnormalities that were surgically corrected between 2015 and 2023. Arteriovenous malformations (AVMs) located in the head, neck, and paragangliomas with jugular/carotid body localization are combined by intense shunting blood flow and shared requirements for the embolic agent used in endovascular treatment (such as penetration, distribution, delayed polymerization, and controllability). An analysis of the literature was also conducted. Results showed 18 patients diagnosed with neck paragangliomas of the carotid body and jugular type. Five patients with arteriovenous malformation (AVM) of the face and neck were included, consisting of sixteen females and seven males with an average age of 55 ± 13 years. Endovascular procedures were performed using NAGLEMs (ONYX (Medtronic, Irvine, CA, USA), SQUID (Balt, Montmorency, France), and PHIL (Microvention, Tustin, CA, USA)) and dimethyl sulfoxide (DMSO)-compatible balloon catheters. All patients achieved complete or partial embolization of hypervascularized formations using one or more stages of endovascular treatment. Additionally, three AVMs of the face and two paragangliomas of the neck were surgically excised following embolization. In other instances, formations were not deemed necessary to be removed. The patients’ condition upon discharge was assessed by the modified Rankin Scale (mRs) and rated between 0 and 2. Conclusion: Currently, NAGLEMs are predominantly used to treat hypervascularized formations in the neck and head due to their fundamental properties. These properties include a lack of adhesion and a delay in predictable polymerization (after 30–40 min). NAGLEMs also exhibit excellent distribution and penetration throughout the vascular bed of the formation. Adequate controllability of the process is largely achieved through the presence of embolism forms of different viscosity, as well as excellent X-ray visualization.
A Contemporary Review of the Genomic Associations of Coronary Artery Myocardial Bridging
Authors: Moore Peyton , Murdock Paul , Ramanathan Akash , Sathyamoorthy Mohanakrishnan
Published: December 2023

Background: Myocardial bridging (MB) is a congenital coronary artery anomaly that has limited molecular disease state characterization. Though a large portion of individuals may be asymptomatic, the myocardial ischemia caused by this anomaly can lead to angina, acute coronary syndrome, coronary artery disease, and sudden cardiac death in patients. Objective: This study aims to summarize and consolidate the current literature regarding the genomic associations of myocardial bridge development and, in doing so, prompt further investigation into the molecular basis of myocardial bridge development. Methods: We performed a systematic literature review of myocardial bridging using the key search terms “Myocardial Bridging” AND (“Gene” OR “Allelic Variants” OR “Genomic”) in the databases of PubMed, CINAHL, EMBASE, and Cochran. We then performed a detailed review of the resulting abstracts and a full-text screening, summarizing these findings in this report. Results: In total, we identified eight articles discussing the associated genomics behind MB development. Studies included review articles, case reports and genomic studies that led to the discussion of several genes: DES (E434K), FBN1 (I1175M), and COMMD10; MACROD2, SLMAP, MYH7 (A1157G), and DPP6 (A714T); MYH7 (A862V); SCN2B (E31D); and NOTCH1 (R2313Q), and to the discussion of miRNAs (miR-29b, miR-151-3p, miR-126, miR-503-3p, and miR-645). Conclusions: Our study is the first to summarize the genes and molecular regulators related to myocardial bridges as they exist in the current literature. This work concludes that definitive evidence is lacking, warranting much broader genetic and genomic studies.