bluuebunny/crossref_metadata_2025 huggingface dataset:
Peptide receptor radionuclide therapy for ectopic Cushing’s syndrome caused by metastatic neuroendocrine neoplasms
Authors: Boehm Emma , Hung Terry , Akhurst Tim , Alipour Ramin , Chiang Cherie , Hicks Rodney J , Hofman Michael S , Ravi Kumar Aravind S , Sachithanandan Nirupa , Saghebi Javad , Michael Michael , Kong Grace
Published: October 2024

Background

Metastatic gastroenteropancreatic neuroendocrine neoplasms (GEPNEN) can cause ectopic Cushing’s syndrome (ECS). ECS is highly morbid and medical therapy is complex and can be ineffective. Patients unsuitable for bilateral adrenalectomy (BA) have dismal outcomes. Peptide receptor radionuclide therapy (PRRT) is a rational option for hormone and disease control in ECS caused by NEN with high somatostatin receptor (SSTR) expression.

Aim

To describe the characteristics and outcomes of patients with ECS treated with PRRT.

Methods

Single-centre, retrospective analysis of imaging, biochemistry and outcomes of seven consecutive patients with ECS caused by metastatic GEPNEN treated with PRRT from 2006 to 2023.

Results

Patients were aged 17–75 (female n = 6). The primary site was the pancreas (5/7) and rectum (2/7). Six patients were on medical therapy for ECS at baseline (one had a previous BA). A median of 34.4 GBq of [177Lu]Lu-DOTA-octreotate was given. [90Y]Y-DOTA-octreotate (one patient) and [111In]In-octreotide (one patient) were also used. Five patients had radiosensitising chemotherapy. Five patients had a flare of ECS within 1 week of PRRT cycle 1 (PRRT-C1). Following PRRT-C1, 5/7 patients had complete biochemical resolution of ECS at 1.5–6 months (four ongoing; one recurred after 12 months and had elective BA at 18 months). Best metabolic response on [18F]F-FDG PET/CT: Four patients had a complete metabolic response (CMR), and one had a partial metabolic response. PFS was 3–208 months. Two patients progressed at the first follow-up. The longest ECS remission and CMR continues at >17 years.

Conclusion

PRRT can be effective for ECS caused by metastatic SSTR-positive GEPNEN and should be considered in its treatment algorithm.
FERTILITY CARE IN LOW AND MIDDLE INCOME COUNTRIES: The landscape of assisted reproductive technology access in India
Authors: Tholeti Prathima , Uppangala Shubhashree , Kalthur Guruprasad , Adiga Satish Kumar
Published: October 2024

Historically, infertility has been stigmatized in Indian society, primarily due to societal norms that equate marriage with procreation. In the twentieth century, India focused primarily on over-fertility in its family planning programs, with little attention given to the complexities of infertility. The introduction of assisted reproductive technology (ART) in the late 1970s marked a global revolution, including in India, offering hope to infertile couples. Despite a significant rise in ART clinics offering a wide range of treatment options in recent years, challenges remain, particularly regarding affordability. In India, ART is typically dominated by the private sector as government support remains limited. Efforts to standardize ART practices, including the establishment of the National ART & Surrogacy Registry and the ART Act aim to regulate, improve outcomes, and curb unethical practices. Despite these advancements, the high cost of treatment cycles and lack of insurance coverage limit couples' ability to undergo fertility treatment. Addressing these issues requires a multifaceted approach, including policy reform, increased public awareness, and the development of affordable treatment options to ensure broader access to reproductive care across India.

Lay summary

India has seen a significant rise in infertility clinics, predominantly in the private sector, catering to the need for increased infertility rates. With regulatory policies enforced by the government, standards for the establishment and functioning of assisted reproduction clinics have been prescribed. However, accessibility and affordability of these services remain a question for many infertile couples, especially in rural areas, as infertility treatment costs are high and are not subsidized by the government. Strategies are required to address the financial challenges as well as the shortage of qualified professionals in the assisted reproduction industry. In this review, we chart the development of assisted reproduction in India, with a focus on the regulatory policies and the current challenges that prevent broader access to reproductive care.
La Prefectura: Extinción o reincorporación constitucional en el bicentenario de creación
Authors: Girón Román Gonzalo
Published: October 2024

Peru in the bicentennial has debated the imminent extinction of the political-legal entity “Prefecture” in the face of the proposal - controversial and countercurrent - of subsistence in its bicentennial precisely on its constitutional reincorporation as a possibility of becoming an adequate channel for citizen demand, which articulate the three levels of government and contribute to governance effectively. It is based on a historical description of the previous regulatory framework, debates and sources of the Constitution of 1823 that incorporated the Prefecture as the main axis of government in the interior of the country. Likewise, we develop the transition of this entity in the 19th and 20th centuries until its episodic withdrawal from the 1979 Constitution. Finally, the current role of the Prefecture and its coexistence with the three levels of government are described, the proposal for its Constitutional reincorporation is raised, and the current political context of decentralization is analyzed. recognizing the current trend that would justify the extinction of the Prefecture.
La colaboración con el delito de terrorismo en el Perú
Authors: Maza Lupuche Juan Arturo
Published: October 2024

En este artículo se va a analizar una de las modalidades del delito de terrorismo como es la colaboración con el terrorismo analizando cada uno de los elementos que la conforman como es el bien jurídico protegido, los sujetos activo y pasivo, conductas típicas, así como su grado de desarrollo. Este delito es de suma importancia pues si bien ha habido una respuesta efectiva del Estado para la lucha de este delito, aún en las zonas andinas de nuestro país se realizan conductas de colaboración con una organización terrorista siendo que estas organizaciones se están reestructurando nuevamente para crear zozobra y alarma en la población peruana. De allí su importancia para conocer un poco más sobre el citado delito.
La colaboración eficaz en las personas jurídicas y el presupuesto de la responsabilidad penal
Authors: Enco Tirado Amado Daniel
Published: October 2024

The article that is submitted for consideration by the academic community deals with the relationship that exists between effective collaboration in legal entities and their criminal liability. First of all, it should be noted that the objective of the article is to analyze the existing deficiencies in the regulation of criminal liability and the effective collaboration of legal entities in Peru and how these deficiencies could affect the purposes of the criminal process. Secondly, the materials used are the norms, doctrine and jurisprudence that concern the topic. Regarding the method, we will say that our research is qualitative-interpretive in nature, since it is an analysis of the doctrine and normative interpretation of the models of criminal liability of legal entities. Regarding the results, we will say that there is a deficient regulation of the criminal liability of legal entities, marked by the lack of coherence between Law No. 30424, Law that regulates the administrative responsibility of legal entities for the crime of transnational active bribery, and the political-criminal motives that supported the bill of origin.
Blockchain como medio probatorio procesal
Authors: Huamán Morales Gerardo
Published: October 2024

La aparición de la tecnología Blockchain, junto con la primera criptomoneda llamada Bitcoin, han causado el inicio de una revolución tanto tecnológica como social y económica. Se habla una nueva forma de entender la economía, de una nueva fase de la internet llamada Web 3.0 e incluso, de nuevas formas de relación social.La tecnología Blockchain nació en un contexto particular; se vincula con el nacimiento de otro tipo de bien digital: el Bitcoin que surgió en el 2008 en el contexto de la crisis económica de ese año, luego del estallido de la “burbuja financiera” debido a la desconfianza originada por la gran cantidad de riesgosas hipotecas subprime. En este contexto, Satoshi Nakamoto envió varios correos a personas vinculadas al ecosistema ciberpunk y cripto anarquista, donde se difundió el white paper de Bitcoin; en ese documento se hace mención al término “cadena de bloques”, así como su función y la forma cómo actúa validando las transacciones. Su naturaleza descentralizada implica que cada uno de los nodos de un blockchain contiene toda la información de las transacciones realizadas en la red por lo que la información se encuentra segura y es de fácil acceso.La blockchain puede ser considerada como prueba informática en algunos casos, así como también como un tipo pericia. La verdadera pregunta es si será sencillo aplicar este conjunto de conocimientos en la actividad probatoria de un proceso. cabe preguntarnos qué tipo de medio probatorio sería blockchain. ¿Es documento típico o es atípico? ¿Cómo se propondría dentro de la litis? ¿Cuál sería su actuación?Recién en la década del 2010 fue cuando empezaron a admitirse pericias relacionadas con la misma la blockchain en los países del primer mundo; en nuestro país el tema es muy poco conocido y es de esperar que muchos de los operadores de justicia ignoren su existencia, y quienes la conozcan tengan muchas dificultades al momento de interpretar una pericia, una opinión, o incluso un medio de prueba que esté relacionada con blockchain.
Investigating the Determinants of Herd Behavior: an Application of the Hwang–Salmon Method to the Turkish Banking Sector
Authors: Ay Bayram Erkin , Göçmen Yağcilar Gamze
Published: October 2024

Efficient financial markets are important for pricing assets at fair value. In an efficient market, investors are rational in the face of fast and accurate information flow, evaluate the information correctly, and reflect it in their pricing decisions. However, particularly in times of crisis and uncertainty, it is observed that some market participants hesitate in their decision-making processes, imitate the behavior of other individuals whom they consider reputable because they cannot rely on their own knowledge and experience, and try to follow the trend. This tendency, which is called herd behavior, destroys market efficiency and prevents correct price formation. Therefore, it is important to identify its determinants. The purpose of the study is analyzing the precense and determinants of herding behavior in the Turkish banking sector during the period 17.10.2017–10.11.2023. Herd behavior is identified using the Hwang–Salmon method, and logistic regression analysis and the Kruskal–Wallis test are applied to identify its determinants. The findings reveal that herding behavior is associated with the rise in risks and returns as well as the fall in interest rates and exchange rates.
Can We Effectively Allocate Time for Work and Life and Be Happy? The Empirical Evidence from Self-Employed Persons in Lithuania
Authors: Tauraitė Viktorija
Published: October 2024

There is not enough attention paid to the analysis of time allocation in the context of happiness. Perhaps it is because happiness economics is an expanding interdisciplinary field. So, recommendations for self-employed persons in Lithuania how daily time should be effectively allocated for life (sleep, personal care, study, housework, family care, leisure, travel and other activities) and work in order to be happy still remain an open question. In this paper the specific recommendations about it are provided for that case. So, this paper analyses two phenomena, i.e. time allocation and happiness. The main attention is given to self-employed persons in Lithuania during 2019 years. Data collection (time diary, survey, interview) and optimization methods are used to identify how daily time should be effectively allocated for two main areas (work and life) in order for self-employed persons to be happy. Having mathematical modeling of time allocation and happiness accomplished, it has been found that 36.1% of day time should be allocated for work and the rest time of the day (63.9%) should be allocated for life. The person’s levels of job satisfaction, life satisfaction and happiness should be equal to 9 points (on a ten-point scale). In this case, monthly net income would be 1001 euros and desirable monthly net income 1101 euros. The number of children should be two. The scientific and practical uniqueness of this article lies in the creation of a mathematical model that can determine how to effectively allocate work time and life time in order for a person to be happy. Although the mathematical model constructed in this paper is based on Lithuanian data, it is not country specific.
PERBBAIKAN GRADE RESISTANCE DAN ROLLING RESISTANCE TERHADAP FUEL RATIO
Authors: Hadi Irza Azzahra Putri , Haryono Ahmad Fauzan , Arofah Nurmaya
Published: October 2024

PT Antareja Mahada Makmur Jobsite MHU berlokasi di Loa Kulu, Kutai Kartanegara, Kalimantan Timur. Berdasarkan penelitian di lapangan terdapat banyak segmen jalan yang memiliki grade yang tinggi dan rolling resistance yang besar, sehingga produktivitas dan konsumsi bahan bakar tidak optimal. Tujuan dari penelitian ini adalah untuk memperbaiki geometri serta kondisi jalan angkut agar produktivitas dan konsumsi bahan bakar lebih optimal, serta mengetahui pengaruh geoemtri dan kondisi jalan angkut terhadap produktivitas dan konsumsi bahan bakar hauler. Penelitian ini menggunakan metode analisis kuantitatif, data primer yang diambil adalah cycle time hauler, geometri jalan angkut, uji menggunakan Dynamic Cone Penetrometer, dan data amblasan. Perhitungan produktivitas alat angkut dihitung dengan mengetahui berapa lama siklus dari alat angkut, sedangkan perhitungan konsumsi bahan bakar dilakukan menggunakan parameter load factor dengan pendekatan Rimpull. Produktivitas alat angkut pada lokasi penelitian sebesar 102.33 BCM/jam dan konsumsi bahan bakar alat angkut sebesar 70.3 liter/jam. Setelah dilakukan perbaikan yaitu membuat jalan Integritas baru dengan lebar jalan sesuai standar (30 meter) dan grade lebih landai, serta rolling resistance < 2%. Produktivitas alat angkut menjadi bertambah dan konsumsi bahan bakar menurun. Berdasarkan perhitungan produktivitas alat angkut setelah perbaikan menjadi 111.2 BCM/jam dan konsumsi bahan bakar hauler menjadi 59.4 BCM/jam. Hal tersebut membuat fuel ratio alat angkut juga ikut menurun yaitu menjadi 0.53 L/BCM.
PERBANDINGAN PEMODELAN ELEVASI TOP ZONA BEDROCK DENGAN METODE ORDINARY KRIGING DAN SEQUENTIAL GAUSSIAN SIMULATION
Authors: Khaq Muhammad Nuzul , Bargawa Waterman Sulistyana , Winarno Eddy
Published: October 2024

Zona bedrock tersusun dari batuan dasar segar dan masif yang menjadi zona batas penambangan (bluezone) karena tidak mengandung mineral ekonomi. Penaksiran secara tepat terhadap posisi horizon bagian atas zona bedrock sebagai batas luar zona bijih pada pemodelan endapan nikel laterit harus dilakukan untuk mendapatkan deskripsi tubuh bijih yang optimal. Metode interpolasi yang sering digunakan saat ini adalah metode ordinary kriging. Metode interpolasi kriging memiliki karakteristik negatif berupa smoothing effect. Metode yang sering digunakan untuk mengurangi smoothing effect dari metode ordinary kriging adalah metode sequential gaussian simulation. Berdasarkan hal tersebut, penelitian ini dilakukan untuk memperkirakan model horizon bagian atas zona bedrock dengan menggunakan metode ordinary kriging dan sequential gaussian simulation. Metode yang dilakukan dalam penelitian ini terdiri dari pengumpulan data, menentukan elevasi top zona bedrock, analisis statistik deskriptif, analisis geostatistik, perkiraan elevasi top zona bedrock dengan metode ordinary kriging dan sequential gaussian simulation dan analisis validasi model. Hasil dari penelitian ini menunjukkan model elevasi top zona bedrock ordinary kriging yang memberikan model yang smooth, sedangkan hasil realisasi SGS mampu memberikan gambaran heterogenitas elevasi berdasarkan data sampel elevasi top zona bedrock. Hasil analisis error terhadap sampel data elevasi top zona bedrock juga menunjukkan hasil E-type simulasi SGS lebih baik dibandingkan ordinary kriging.
ARTIFICIAL NEURAL NETWORK APPLICATION FOR HEAVY EQUIPMENT GAS EMISSION CONTROL ON ROCK BREAKING ACTIVITY
Authors: Soerjodibroto Mulyanto , Amrizal Victor , Prabowo Wishnu
Published: October 2024

Applications of artificial intelligence (AI) software in mining activities, both for equipment automation, data analysis and processing, identification of patterns and features data, upto determining solutions have been carried out by several mining companies. This is mainly due to mining activities naturally are always facing uncertainty and natural variability conditions. One of the AI applications is to control fuel consumption aimed at increasing the efficiency of fuel use, while in the same time reducing exhaust gas emissions from internal combustion engines, which are one of the causes of rising greenhouse gases (GHG).Utilization of AI in aimed to control fuel consumption in Rock Breaking activities in limestone quarry in the Sukabumi area, resulting a deviation rate of 0.17 for  fuel consumption prediction, which is fall in “ the good category”. Increasing the volume and variety of data for “machine learning” would  improve AI performance.Keywords : Artificial intelligence application,  fuel consumption, ICE gas emission control.
VALUE ENGINEERING APPLICATION FOR ELEMENT ANALYSIS OF HEAVY EQUIPMENT EVACUATION TO GET HIGHER ACTIVITY VALUE
Authors: Soerjodibroto Mulyanto , Putri Nadila Guspani
Published: October 2024

The safety of workers and equipment from the dangers of flyrock blasting is an absolute must. The purpose of this safeguard is in line with the K3 and K Operational Mining principles as emphasized in the Good Mining Practice guidelines. It is undeniable that in order to meet these safety requirements, it is necessary to sacrifice costs as well as loss of equipment production  hours. With reference to the principles of Value Engineering Analysis, research was carried out in an effort to reduce these sacrifices by reducing the farthest flyrock ejection distance of  bench overburden blasting  at PT. Antareja Mahada Makmur site in East Kalimantan  without violating the safety requirements as meant in the Minister of ESDM Decree no. 1827/2018 Attachment 2 page 79 points (ix). The research was carried out by modifying the parameters of the detonation ladder, especially those related to the explosives factor, to obtain safe distance from the farthest ejection of flyrock which is smaller than the 300 meter requirement. From the experimental series, it was obtained that the safe distance from the farthest ejection of flyrock is  150 meters as a reference for heavy equipment evacuation. This brings benefits to the company in the form of reducing sacrifices up to ± 50% from the previous without reducing the required Safety Value. Keywords : Flyrock , Safe distance , Value Engineering.
ANALISIS INKLUSI FLUIDA UNTUK EKSPLORASI MINERAL DI SUMUR UJI PEMBORAN BWS-H01, DESA SUMBERBOTO, KECAMATAN WONOTIRTO, BLITAR, JAWA TIMUR
Authors: Rachmawati Dwi
Published: October 2024

Daerah penelitian berada di Kabupaten Blitar, Jawa Timur,  Kecamatan Wonotirto, dengan koordinat 112o 08’41.71”BT-112o09’16.1”BT dan 8o14’52.94” LS-8o15’15.64”LS. Daerah penelitian merupakan bagian Zona Pegunungan Selatan Jawa Timur dan secara regional termasuk dalam Formasi Mandalika. Sumur BWS-H01 (TOD 451 m, inklinasi 90o) dan merupakan kelanjutan dari Sumur Uji yang dilakukan pada tahun 2004.Inklusi dikenal sebagai material berukuran mikro yang terdapat didalam suatu mineral, pada umumnya terdapat tiga fasa yaitu fasa padat, cair, maupun gas (Roedder, 1974; dalam Yuwono, 1994). Analisis inklusi fluida bertujuan untuk mengetahui temperatur dan salinitas pada saat pembentukan urat mineralisasi. Inklusi fluida dilakukan pada empat conto batuan pada kedalaman 257,1 m, 342 m, 401,1m dan 430,1 m . Hasil dari pengukuran keempat conto inklusi fluida menghasilkan Th (Temperatur homogenisasi) berkisar pada temperatur 100-219oC Tm (Temperatur leleh) berkisar pada temperatur -0,3 sampai -1oC, dan salinitas NaCl 0,5-1,7 %Wt NaCl. Berdasarkan kisaran temperatur 100oC-219oC, sistem hidrotermal pada sumur BWS-H01 termasuk dalam sistem epitermal.  Salinitas yang rendah menunjukkan fluida yang lebih berperan berupa air meteorik yang memiliki pH netral.
OVERVIEW PERBANDINGAN HASIL UJI KUALITAS KIMIA TANAH ASPEK pH, C ORGANIK, N TOTAL, DAN KTK LAHAN REKLAMASI TAMBANG, STUDI KASUS : PERUSAHAAN TAMBANG KOMODITAS NIKEL, BATUBARA, DAN TIMAH
Authors: Dewi Mesias Citra , Umar Muh Adyon , Suryaningtyas Dyah Tjahyandari
Published: October 2024

Reklamasi merupakan bagian yang tidak bisa dipisahkan dari kegiatan pertambangan dan merupakan kunci akhir apakah suatu tambang tersebut dapat dikembalikan sesuai peruntukannya. Pada penelitian ini dilakukan dengan metode literature review, dimana sebuah metode yang sistematis, eksplisit dan reprodusibel untuk melakukan identifikasi, evaluasi serta sintesis terhadap karya-karya hasil penelitian. Hasil penelitian menunjukkan sampel tanah diambil pada lahan reklamasi, pada satu titik sampling yang memiliki karakter fisik kondisi tanah yang sama. Dari ketiga komoditas yaitu nikel, batubara, dan timah didapatkan bahwa karakteristik tanah berupa pH dengan derajat keasaman tertinggi atau di bawah kriteria tanah ideal (pH 5.5 – 7.5) adalah komoditas timah. Nilai C organik untuk semua komoditas berada pada nilai sangat rendah. Untuk nilai C total berada pada tingkat kesuburan sangat rendah pada komoditas batubara dan timah. Pada komoditas timah memiliki nilai kapasitas tukar kation yang sangat rendah sedangkan 2 (dua) komoditas lainnya sedang.
STUDI FRAGMENTASI BATUAN PELEDEKAN MENGGUNAKAN METODE TOP AIR DECKING
Authors: Nabella Andromeda , Razak Supardi
Published: October 2024

Fragementasi merupakan salah satu indikator keberhasilan dari suatu kegiatan peledakan. Lokasi penelitian telah menggunakan metode top air deck sebagai upaya menghasilkan fragmentasi yang baik. Karena belum adanya ketentuan nilai air deck length, berakibat fragmentasi kurang baik. Air deck length (ADL) merupakan parameter penting dalam penerapan peledakan air decking, dimana ADL dipengaruhi oleh nilai air deck factor (ADF). Nilai ADF ini berbeda-beda sesuai massa batuan sesuai pembobotan rock mass rating (RMR). Pada lokasi penelitian penerapan nilai ADL beragam (0,86 – 2,48 meter) dan menghasilkan nilai ADF 0,32 – 0,63. Berdasarkan analisis fragmentasi aktual diperoleh distribusi fragmentasi ukuran fragmentasi rata-rata (P80) adalah 76,34 cm dan persentase lolos rata-rata pada ukuran 75 adalah 78,6% dan persentase rata-rata boulder 21,4%. Selanjutnya dilakukanlah perhitungan ADL dengan pembobotan RMR batuan di lokasi penelitian. Pembobotan rock mass rating batuan overburden pada lokasi penelitian adalah 56 (fair). Nilai ADF yang diperoleh adalah 0,3 dan selanjutnya dilakukanlah simulasi peledakan dengan ADF 0.3. Analisis fragmentasi dari simulasi peledakan yang direkomendasikan adalah ukuran fragmentasi rata rata (P80) yang sebelumnya 76,34 cm menjadi 55,25 sehingga ukuran berkurang sebesar 21,73 cm dan persentase lolos pada ukuran 75 cm yang sebelumnya 78,6% menjadi 93% sehingga persentase lolos bertambah 14,3%. Serta persentase bouldernya menurun dari 21.4% menjadi 7%. Kata kunci: Air Deck Factor, Air Deck Length, Fragmentasi, Peledakan, Top Air Deck.
نقد متن الحديث عند نور الدين عتر وصلاح الدين الأدلبي
Authors: Pahrudin Ade , Bahrul Nurfadhilah
Published: October 2024

Some fabricated hadiths spread in an era after the Companions, therefore, the importance of hadith criticism was underestimated. Its provenance, and had a strong influence on the later and contemporary scholars in finding the text criticism, the two researchers identified his interest in the criticism of the text of the hadith and its comparison with the contemporary scholars, Nur al-Din Atar and Salah al-Din bin Ahmed al-Idlibi, aiming to know the criticism of the text with them, and a comparison between their methodologies. The researchers' approach in this research is a comparative study, where the researchers read several books related to this research, taking the opinions of scholars from the advanced and contemporary scholars, and then making a comparison between their approaches.  Among the most important results are criteria for criticizing the text, including the criteria agreed upon: (1) contrary to the Qur’an, (2) contrary to hadith, (3) contrary to reason, sense, or history, and (4) that the text does not resemble the words of the prophecy, and includes risks and weaknesses. And Samajah. And there is no difference between Salah al-Din ibn Ahmad al-Adlbi and Nour al-Din Atar in the criticism of the text except in the easy measures, which are (1) in the methodology of Nour al-Din Atar, he mentioned the rickety, and in the methodology of al-Adlbi he mentioned its addition, which is the slander and the samajah. (2) In the methodology of Nur al-Din Atar, there is a criterion: “to search for the hadith, then there is no finding among its people from the chests of the narrators and the stomachs of the books, after the hadiths have been extrapolated and written down.” However, this criterion is not found with Al-Adlbi. The approach of Nur al-Din Atar There is a measure: collecting hadith by extrapolating the chapters, and this measure does not exist with al-Adlbi. The methodology of criticism of the text according to Nur al-Din Atar and Salah al-Din ibn Ahmad al-Adlabi are all in agreement with the methodology of criticism of the text according to the audience. Keywords: matn hadith, method, criticism of hadith.
التفسير العلمي للقرآن بإندونيسيا: منهجه وتطبيقاته
Authors: Nuha Ulin
Published: October 2024

This research is aimed at looking at scientific interpretation method in Indonesia and its application. The literature that is the object of this research is a book entitled Time in the Perspective of the Qur'an and Science which was written by a group of ulama and scientists from Lajnah Pentashihan Mushaf al-Qur'an and the Indonesian Institute of Sciences (LIPI). This research belongs to the type of library research, where the data source is obtained from books and papers. In analyzing research objects, the author uses the formulation of the scientific interpretation method written by Abdul Jabbar Saqa and the author of the book Time in the Perspective of the Qur'an and Science. From the results of this research, it was found that the book Time in the Perspective of the Qur'an and Science was written by popular scholars in Indonesia: tafsir scholars and scientists. From all the descriptions it is understood that this book pays attention to aspects of linguistic rules, al-Qur'an sciences, and the interpretations of previous scholars. This book of tafsir also separates interpretation and scientific findings, both of which are different. Scientific findings are not interpretations of the Qur'an, but are part of the expansion of the Qur'an's instructions where changes to the findings will not affect the sanctity of the Qur'an.
The Association of the MeMed BV Test With Radiographic Pneumonia in Children
Authors: Ramgopal Sriram , Lorenz Doug , Neveu Melissa , Krauss Jillian , Papan Cihan , Tenenbaum Tobias , Esposito Susanna , Florin Todd A.
Published: October 2024

BACKGROUND

The MeMed BV Test produces a score that increases with increasing likelihood of bacterial infection. We evaluated its association with radiographic pneumonia in children.

METHODS

We performed a secondary analysis of a multicenter prospective study of febrile children 90 days to 18 years presenting to an emergency department. We evaluated the association of the MeMed BV test with radiographic pneumonia in adjusted logistic regression models.

RESULTS

Of 182 children, 74 (41%) had radiographic pneumonia. Among children with a high likelihood of having viral illness per the BV test, 26% had radiographic pneumonia; this increased to 64% among those with a BV test which indicated a high likelihood of bacterial infection. The sensitivity and specificity for radiographic pneumonia when using a BV test classification of moderate or high likelihood of bacterial infection were 60.8% and 62.0%, respectively. A BV test indicating the highest likelihood of bacterial infection had 23.61 higher adjusted odds (95% confidence interval 6.30–88.6) of radiographic pneumonia. The most common radiographic finding among children classified as having a high likelihood of viral infection by the BV test was interstitial opacities. The most common finding among children classified as having a high likelihood of bacterial infection were infiltrates. Except for antibiotic use, clinical outcomes occurred in similar proportions by BV category.

CONCLUSIONS

Children with moderate to high likelihoods of bacterial infection on the BV test had higher odds of radiographic pneumonia. Apart from antibiotic use, the test was not significantly associated with clinical outcomes in this study.
Predictors in Youth of Adult Cardiovascular Events
Authors: Nuotio Joel , Laitinen Tomi T. , Magnussen Costan G. , Sinaiko Alan R. , Bazzano Lydia A. , Daniels Stephen R. , Jacobs David R. , Kartiosuo Noora , Koskinen Juha , Burgner David P. , Kähönen Mika , Raitakari Olli T. , Steinberger Julia , Urbina Elaine M. , Venn Alison J. , Viikari Jorma S. A. , Woo Jessica G. , Dwyer Terence , Juonala Markus
Published: October 2024

BACKGROUND AND OBJECTIVES

Childhood risk factors are associated with cardiovascular events in adulthood. We compared the utility of a risk model based solely on nonlaboratory risk factors in adolescence versus a model that additionally included lipids to predict cardiovascular events in adulthood.

METHODS

The study comprised 11 550 participants from 7 longitudinal cohort studies in the United States, Australia, and Finland with risk factor measurements in adolescence and followed into adulthood. The adolescent risk factors were defined by using clinical standards including overweight or obesity, elevated blood pressure, smoking, and borderline high or high levels of total cholesterol and triglycerides. The main outcomes were medically adjudicated fatal or nonfatal cardiovascular disease events occurring after age 25.

RESULTS

Of 11 550 participants (55.1% female, mean age 50.0 ± 7.7 years), 513 (4.4%) had confirmed cardiovascular events. In a multivariable model (hazard ratio [95% confidence interval]), elevated blood pressure (1.25 [1.03–1.52]), overweight (1.76 [1.42–2.18]), obesity (2.19 [1.62–2.98]), smoking (1.63 [1.37–1.95]), and high total cholesterol (1.79 [1.39–2.31]) were predictors of cardiovascular events (P < .05). The addition of lipids (total cholesterol and triglycerides) into the nonlaboratory model (age, sex, blood pressure, BMI, and smoking) did not improve discrimination in predicting cardiovascular events (C-statistics for the lipid model 0.75 [SD 0.07] and nonlaboratory model 0.75 [0.07], P = .82).

CONCLUSIONS

Nonlaboratory-based risk factors and lipids measured in adolescence independently predicted adult cardiovascular events. The addition of lipid measurements to nonlaboratory risk factors did not improve the prediction of cardiovascular events.
Dynamic Voltage Mapping of the Post-infarct Ventricular Tachycardia Substrate: A Practical Technique to Help Differentiate Scar from Borderzone Tissue
Authors: Mills Mark T , Calvert Peter , Chiong Justin , Gupta Dhiraj , Luther Vishal
Published: October 2024

During catheter ablation of post-infarct ventricular tachycardia (VT), substrate mapping is used when VT is non-inducible or poorly tolerated. Substrate mapping aims to identify regions of slowly conducting myocardium (borderzone) within and surrounding myocardial scar for ablation. Historically, these tissue types have been identified using bipolar voltage mapping, with areas of low bipolar voltage (<0.50 mV) defined as scar, and areas with voltages between 0.50 mV and 1.50 mV as borderzone. In the era of high-density mapping, studies have demonstrated slow conduction within areas of bipolar voltage <0.50 mV, suggesting that this historical cut-off is outdated. While electrophysiologists often adapt voltage cut-offs to account for this, the optimal scar-borderzone threshold is not known. In this review, we discuss dynamic voltage mapping, a novel substrate mapping technique we have developed, which superimposes data from both activation and voltage maps, to help delineate the post-infarct VT circuit through identification of the optimal scar-borderzone voltage threshold.
CAUSES OF PAIN IN THE MUSCLES OF THE LOWER EXTREMITIES IN CHILDREN WITH CEREBRAL PALSY
Authors: Danilov Oleksandr , Shulga Oleksandr , Kucheruk Oleksandr , Bandrina Kateryna
Published: October 2024

A high level of muscle spasticity in children with cerebral palsy is one of the causes of degenerative and dystrophic changes in tissues. Against the background of high spasticity, there is a violation of blood flow in the vessels of the lower extremities, which leads to changes in subfascial pressure and the formation of primary pain syndromes. The analysis of the literature shows the need to study the issues related to the mechanism of formation of changes in the muscles and determine the primary causes of pain. Objective. Тo study the mechanism of changes in the muscles of the lower extremities, as well as the primary causes of pain syndrome. Methods. The analysed indicators were obtained during the treatment of 40 patients with cerebral palsy, who were divided into 3 groups depending on the muscle tone disorder. Clinical and instrumental methods were used to examine patients. The data obtained were statistically processed with the determination of M ± m, the coefficient of reliability according to Student’s criteria. Results. According to the results of the study, high spasticity leads to impaired blood flow and increased subfascial pressure in the musculofascial sheaths. There is an inverse correlation between the increase in subfascial pressure, the diameter of the vessel lumen and blood flow velocity. This is one of the causes of degenerative and denervation changes in muscles and fascia. It was proved that the occurrence of primary pain in the lower extremities is caused by various etiological causes: tissue ischemia; increased subfascial pressure; narrowing of pathologically significant anatomical areas in which nerves lie; degenerative and dystrophic changes in the joints. Conclusions. The study found that the cause of changes in the muscles and fascia is a violation of blood flow, a change in subfascial pressure in the musculofascial cases of the lower extremities. The occurrence of pain in the lower extremities in children with cerebral palsy is multifactorial in nature and consists of myofascial, articular, and tunnel syndromes.
CHANGES IN THE CONTENT AND ACTIVITY OF MUSCLE PROTEINS AS A MARKER IN THE CASE OF EXPOSURE TO IONIZING RADIATION IN ANIMALS
Authors: Lurin Igor , Khomenko Igor , Stepanov Gennadiy , Tertyshnyi Serhii , Vastyanov Rooslan , Tiron Oksana
Published: October 2024

Objective. To find out the specifics of muscle tissue contraction under the conditions of exposure to low doses of ionizing radiation in parents and their irradiated offspring by evaluating changes in the content of contractile proteins and ATPase activity of skeletal and cardiac muscles. Methods. Experimental studies were conducted on 50 rats. Animals were randomized as follows: group 1 — intact sexually mature rats; 2 — sexually mature animals irradiated with a dose of 1.0 Gy; group 3 — monthold rats obtained from intact individuals; group 4 — month-old rat pups obtained from parents irradiated with a dose of 1.0 Gy; group 5 — month-old rats obtained from animals irradiated with a dose of 1.0 Gy, which were irradiated at the same dose. The results. Muscle dysfunction in irradiated offspring and parents is manifested by a decrease in the content of contractile proteins, functional dysfunction of the actomyosin bridge, and a decrease in the ATPase activity of contractile proteins. Marked muscle dysfunctions during the post-radiation time period may be the reason for the formation of orthopedic pathology in a significant contingent of irradiated persons. Conclusions. The expression of muscle dysfunction in the offspring of irradiated animals, which were also exposed to ionizing radiation, is greater than the corresponding processes in their irradiated parents, which indicates the mediation of muscle dysfunction in the second generation of irradiated animals by epigenetic mechanisms. Marked muscle dysfunctions during the post-radiation time period may be the reason for the formation of orthopedic pathology in a significant contingent of irradiated persons
THE INFLUENCE OF THE CULTURE OF FIBROBLASTIC CELL ELEMENTS ON THE INDICATORS OF THE METABOLISM OF CONNECTIVE TISSUE IN EXPERIMENTAL ANIMALS
Authors: Magomedov Sadrudin , Polyachenko Yurii , Kostrub Оlexandr , Blonskyi Roman , Zasadnyuk Ivan
Published: October 2024

The number of patients with degenerative tendon disease affects millions of people both among athletes and the general population, causing significant socio-economic consequences. Despite the availability of various methods of conservative and surgical treatment, more than a third of patients experience constant pain. Objective. To study the indicators of the metabolism of connective tissue in animals with a model of degenerative damage to tendons against the background of the introduction of a culture of fibroblastic cell elements. Methods. Therefore, the development of methods for restoring the structure of tendons using cell cultures, in particular fibroblasts, will allow to optimize the course of reparative processes, reduce the risk of complications during surgical intervention and accelerate healing, and at the molecular level — to improve the structure of collagen fibers. Laboratory studies of biochemical markers of a tendon with a degenerative-dystrophic lesion and against the background of the introduction of cell culture can help in the differential diagnosis of its extracellular matrix. Results. The experimental data obtained by us indicate the presence of differences in the biochemical markers of tendons with degenerative-dystrophic lesions in rats 7, 21, and 45 days after the introduction of culture of fibroblastic cell elements. However, 45 days after the introduction of the culture of fibroblast cell elements, the normalization of metabolic processes in the extracellular matrix of connective tissue occurs, namely, the activity of collagenase and the concentration of protein-bound hydroxyproline approaches normal values. This indicates the predominance of the synthetic phase over the catabolic one in collagen metabolism. Conclusions. In this context, the introduction of culture of fibroblastic cell elements, as an alternative anti-inflammatory method, may provide another potential opportunity in the treatment of chronic degenerative-dystrophic lesions of the Achilles tendon.
METHODS OF PERCUTANEOUSFIXATION OF FRAGMENTS IN SUPRACONDYLAR HUMERUS FRACTURES IN CHILDREN AND ADOLESCENTS
Authors: Buryanov Olexander , Kvasha Volodymyr , Naumenko Valerija , Kovalchuk Dmytro , Pylypchuk Oleg , Omelchenko Taras , Rohozynskyi Valentyn
Published: October 2024

The aim of this study is to conduct a meta-analysis and evaluate the clinical efficacy and safety of crossed and lateral fixation of fragments in supracondylar humerus fractures in children and adolescents. Methods. A comprehensive literature search was conducted in the PubMed and EMBASE databases from 2015 to December 2023 using the following search terms: "supracondylar fractures of distal humerus in pediatric patients", "treatment", "methods of fixation", "pinning configuration", "biomechanical analysis of pin placement". According to the inclusion and exclusion criteria, the literature sources of anatomic-biomechanical and clinical studies related to the use of crossed and lateral fixation of fragments in the case of supracondylar fractures of the humerus in children and adolescents were selected and analyzed. The review was prepared in accordance with the recommendations of the "Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines." Results. A comparison of results from experimental studies investigating the degree of stabilization achieved in the crossed and lateral configurations of fixation structures reveals conflicting conclusions due to the heterogeneity of designs implemented. The principal limitation of lateral fixation is the increased risk of failure of fixation. The outcomes of clinical trials (Flynn criteria) demonstrate that both types of fracture fixation yield equivalent clinical outcomes. One disadvantage of crossed fixation is the risk of iatrogenic ulnar nerve damage, while another disadvantage is the increased complexity of the surgical technique. Conclusions. The results of anatomical and biomechanical studies indicate that cross-fixation provides more rigid fixation of fragments in supracondylar humerus fractures in children and adolescents. Nevertheless, clinical outcomes based on radiological and functional data (including Flynn's score) demonstrate no significant distinction between the two types of fixation configurations. However, they do indicate a notable risk of iatrogenic ulnar nerve damage in cross fixation, which justifies the necessity to utilise a mini-open technique in the medial fixation construct.
Armament of the Maeotian Horsemen of the 4th Century BC (Based on Materials from the Prikubansky Burial Ground)
Authors: Limberis Natalya , Marchenko Ivan
Published: October 2024

The horsemen, whose graves were discovered in the Prikubansky burial ground, represented the elite of the Maeotian army. Weapons were found in 28 burials. The main types of weapons were iron swords, spearheads, and arrowheads. Swords of the Sindo-Maeotian type were found in 26 burials, and in four burials there were two swords of different lengths. The swords differ in the blade width, the design of the transition space between the guard and the blade, and the shape of the bar-shaped pommel. Spearheads could be found in all the burials. Typically, a set consisted of 4–6 both heavy and light spearheads of various types. One dart tip was found among the spear tips in the three sets. Arrowheads were discovered in twenty burials. Sets of arrows consisted of various numbers of pieces, from a few to several dozens. Mostly, iron three-blade arrowheads were used (415 specimens), bronze (three-blade and triangular) were practically out of use (25 specimens), and bone bullet-shaped ones were represented by isolated finds. The arrows were placed in quivers, which were placed next to or under the sword. In the burials with two swords, there were two quivers. Specific types of weapons are long combat knives (30–42 cm) with bone handles found in seven burials. A set of combat knives could consist of 2–4 pieces. On the grounds of the position in the burial, it can be assumed that the knives were located in a special compartment of the quiver, in a case on the sheath of the sword, or in special wooden sheaths. The equipment of the horsemen included iron axes in the two burials. The dating of the equestrian assemblages is based on a narrow chronology of Greek amphorae from different centers of production, which are present in each burial. The high percentage of horseman complexes among the military burials of the Prikubansky necropolis is probably connected with the location of this group of the Maeotian population near the eastern border of the Asian Bosporus.
Revisiting the Issue of Attribution of Some Catacomb Monuments Groups from the South of Eastern Europe in the Late 3rd – early 5th Centuries
Authors: Malashev Vladimir , Krivosheev Mikhail
Published: October 2024

The catacomb funerary ritual had a widespread occurrence among the southern Eastern European population in late Roman times and at the beginning of the Great Migration Period. The Alan culture monuments of the 2nd – 4th centuries AD from the North Caucasus and the “Alans-Tanaites” nomadic culture of the late 3rd – 4th centuries AD feature the burial ritual most widely and vividly. Evidently, the migration occurred in a westerly direction from the “Alan-Tanaitian” culture area in the late 3rd century, resulting in the appearance of a group of under-kurgan burials in the steppe zone of the Dniester-Danube interfluve. It is possible that the people who left these kurgans in the 4th century were assimilated by the Chernyakhov culture bearers and switched to a sedentary lifestyle, having lost the kurgan funeral ritual (Belen’koe burial ground) but retained the catacomb burial structure of almost predominantly type II. The catacomb burials under the kurgans graphically feature the Alans-Tanaites fate after the encounter with the Huns, who defeated and subjugated the Alans-Tanaites, partly incorporating the vanquished population into their military and political union. The Alans-Tanaites took part in the campaign in Transcaucasia and Western Asia as part of the Hunnic army (395–398), as evidenced by the specific forms of the catacombs in the kurgans of the Palasa-Syrt burial ground from the Western Caspian region. A group of kurgan catacombs in the Middle Don and the Left Bank of the Dnieper features the partial outflow of the Alans-Tanaites from the Volga-Don steppes under the pressure of the Huns in the course of their expansion. A part of the Alans-Tanaites participated in the movement of the Huns to the west, as evidenced by the catacombs in the Budzhak steppe dating back to the last quarter of the 4th century.
Promoting Equity in Culturally Diverse Schools: A Literature Review of Third Space Pedagogy
Authors:   Northwest Nazarene University, Harrison Sarah , Curtis Heidi ,   Northwest Nazarene University
Published: October 2024

The increasingly culturally diverse settings present within today’s P-12 schools necessitate improved pedagogical practices to develop more culturally inclusive and equitable learning environments. Third-space pedagogical practices demonstrate potential as an approach for increasing educational equity by promoting cultural hybridity among diverse students and stakeholders through negotiated sociocultural perspectives and interactions. This literature review summarizes recent scholarship surrounding third-space pedagogy, including discussions of how educators can foster third-space relationships and design third-space learning opportunities in diverse educational settings. In addition, lessons from COVID-19 third-space learning opportunities are discussed as a model for re-envisioning equitable instructional practices post-pandemic.
Liberalismo e republicanismo: avanços e contradições sobre o espaço público no pensamento de Hannah Arendt
Authors: Uchoa Marcela
Published: October 2024

Resumo: O estudo das revoluções burguesas realizado por Hannah Arendt é um importante diagnóstico do impacto das políticas liberais, suas contradições e evolução, na história da democracia; reflete, ainda, as contradições e dicotomias do pensamento da filósofa. O republicanismo moderno, embora crítico do liberalismo, assimilou elementos inerentes à democracia liberal, como a importância da lei, sempre imputada a partir de preceitos políticos ideológicos do seu tempo. Esta análise permite não só compreender as bases do pensamento político da teórica, mas seu desenvolvimento naquilo que denomina espaço público. Este deve ser um lugar de expressão de opiniões, por isso, para Arendt, sem pluralidade; política e liberdade pública ficam comprometidas, na medida em que impossibilitam a conservação de um espaço de efetivação da liberdade. Contudo, em um mundo desigual, quem pode exercer sua cidadania livremente, no espaço público? A promessa liberal propicia tais garantias? Em diálogo com Habermas e para além, pretende-se, com esta investigação, traçar as fragilidades de uma noção burguesa de esfera pública e enunciar a urgência de um ideal de republicanismo alicerçado e legitimado nas demandas populares.