bluuebunny/crossref_metadata_2025 huggingface dataset:
Hylan versus hyaluronic acid for osteoarthritis of the knee: A systematic review and meta‐analysis
Authors: Reichenbach Stephan , Blank Sacha , Rutjes Anne W. S. , Shang Aijing , King Elizabeth A. , Dieppe Paul A. , Jüni Peter , Trelle Sven
Published: November 2007

Objective

To compare the effectiveness and safety of intraarticular high‐molecular hylan with standard preparations of hyaluronic acids in osteoarthritis of the knee.

Methods

We performed a systematic review and meta‐analysis of randomized controlled trials comparing hylan with a hyaluronic acid in patients with knee osteoarthritis. Trials were identified by systematic searches of Central, Medline, EMBase, Cinahl, the Food and Drug Administration, and Science Citation Index supplemented by hand searches of conference proceedings and reference lists (last update November 2006). Literature screening and data extraction were performed in duplicate. Effect sizes were calculated from differences in means of pain‐related outcomes between treatment and control groups at the end of the trial, divided by the pooled standard deviation. Trials were combined using random‐effects meta‐analysis.

Results

Thirteen trials with a pooled total of 2,085 patients contributed to the meta‐analysis. The pooled effect size was −0.27 (95% confidence interval [95% CI] −0.55, 0.01), favoring hylan, but between‐trial heterogeneity was high (I2 = 88%). Trials with blinded patients, adequate concealment of allocation, and an intent‐to‐treat analysis had pooled effect sizes near null. The meta‐analyses on safety revealed an increased risk associated with hylan for any local adverse events (relative risk [RR] 1.91; 95% CI 1.04, 3.49; I2 = 28%) and for flares (RR 2.04; 95% CI 1.18, 3.53; I2 = 0%).

Conclusion

Given the likely lack of a superior effectiveness of hylan over hyaluronic acids and the increased risk of local adverse events associated with hylan, we discourage the use of intraarticular hylan in patients with knee osteoarthritis in clinical research or practice.
Hypomagnesemia associated with chondrocalcinosis: A cross‐sectional study
Authors: Richette Pascal , Ayoub Ghazi , Lahalle Sophie , Vicaut Eric , Badran Abdul‐Monem , Joly Francisca , Messing Bernard , Bardin Thomas
Published: November 2007

Objective

To determine an association between magnesium (Mg) depletion and chondrocalcinosis, which has been reported but not investigated in a cross‐sectional study.

Methods

Prevalence of chondrocalcinosis was investigated in 144 individuals: 72 patients receiving home parenteral nutrition (HPN) compared with 72 age‐ and sex‐matched controls. Presence of chondrocalcinosis was assessed by knee radiographs. Blood serum and globular Mg levels and 24‐hour urinary Mg content were compared.

Results

Mean ± SD age for both patients and controls was 51 ± 17 years, and 51% in both groups were women. Mean duration of HPN was 6.4 years. Prevalence of chondrocalcinosis was markedly higher in patients receiving HPN than controls (16.6% versus 2.7%; P = 0.006, odds ratio [OR] 7.0, 95% confidence interval [95% CI] 1.45–66.1). Mean ± SD serum and globular Mg levels were significantly lower in patients than controls (serum: 0.75 ± 0.09 mmoles/liter versus 0.81 ± 0.08 mmoles/liter, P = 0.0006; globular Mg: 1.8 ± 0.31 mmoles/liter versus 2.0 ± 0.35 mmoles/liter, P = 0.0003). Twenty‐four‐hour urinary Mg level was lower in patients than controls (mean ± SD 3.85 ± 1.50 mmoles versus 5.37 ± 3.71 mmoles; P = 0.001). Prevalence of chondrocalcinosis was significantly higher in patients with a low serum Mg level (OR 13.5, 95% CI 2.76–127.3, P < 0.0001), with a similarly high but not significant occurrence of chondrocalcinosis in patients with a low globular Mg level (OR 4.09, 95% CI 0.603–20.26, P = 0.08) and in patients with a low 24‐hour urinary Mg level (OR 3.9, 95% CI 0.77–16.34, P = 0.05).

Conclusion

Long‐lasting Mg depletion is strongly associated with chondrocalcinosis.
The risk of herpes zoster in patients with rheumatoid arthritis in the United States and the United Kingdom
Authors: Smitten Allison L. , Choi Hyon K. , Hochberg Marc C. , Suissa Samy , Simon Teresa A. , Testa Marcia A. , Chan K. Arnold
Published: November 2007

Objective

To determine whether the incidence of herpes zoster is elevated in patients with rheumatoid arthritis (RA) and whether herpes zoster is associated with use of disease‐modifying antirheumatic drugs (DMARDs) in patients with RA.

Methods

Two retrospective cohort studies were conducted using data from a US integrated managed care database (PharMetrics claims database) from 1998–2002 and the UK General Practice Research Database (GPRD) between 1990–2001. Rates of herpes zoster among patients with RA and randomly sampled non‐RA patients were compared. A nested case–control analysis was performed within each RA cohort to examine the effect of current treatment on herpes zoster risk.

Results

A total of 122,272 patients with RA from the PharMetrics database and 38,621 from the GPRD were included. The adjusted hazard ratios of herpes zoster for patients with RA compared with non‐RA patients were 1.91 (95% confidence interval [95% CI] 1.80–2.03) in the PharMetrics database and 1.65 (95% CI 1.57–1.75) in the GPRD. In the PharMetrics database, current use of biologic DMARDs alone was associated with herpes zoster (odds ratio [OR] 1.54, 95% CI 1.04–2.29), as was current use of traditional DMARDs alone (OR 1.37, 95% CI 1.18–1.59). In the GPRD, current use of traditional DMARDs was associated with herpes zoster (OR 1.27, 95% CI 1.10–1.48). In both data sources, use of oral corticosteroids was associated with herpes zoster regardless of concomitant therapies.

Conclusion

Data from 2 large databases suggested that patients with RA are at increased risk of herpes zoster. Among patients with RA, DMARDs and/or use of oral corticosteroids appeared to be associated with herpes zoster.
Fine specificity of the anti–citrullinated protein antibody response is influenced by the shared epitope alleles
Authors: Verpoort K. N. , Cheung K. , Ioan‐Facsinay A. , van der Helm‐van Mil A. H. M. , de Vries‐Bouwstra J. K. , Allaart C. F. , Drijfhout J. W. , de Vries R. R. P. , Breedveld F. C. , Huizinga T. W. J. , Pruijn G. J. M. , Toes R. E. M.
Published: November 2007

Objective

In classic studies on the genetic background of antibody production, the major histocompatibility complex (MHC) has been shown to act as the most prominent immune response gene that controls the magnitude and the specificity of antibody production. The strongest genetic risk factor for rheumatoid arthritis (RA), the human MHC HLA–DRB1 shared epitope (SE) alleles, predisposes for antibodies against citrullinated proteins (ACPAs). ACPA levels are higher in SE‐positive patients with RA than in SE‐negative patients with RA. The aim of the present study was to determine whether SE influences not only the magnitude but also the specificity of the ACPA response.

Methods

In 2 cohorts of anti–citrullinated peptide 2–positive patients with RA, one from a study of recent‐onset arthritis (n = 206) and the other from a treatment strategy study (n = 141), serum antibodies against a citrullinated peptide derived from vimentin (cVim) and antibodies against a citrullinated fibrinogen peptide (cFibr) were determined by enzyme‐linked immunosorbent assay. HLA–DRB1 genotyping was performed.

Results

In the first cohort, SE alleles were significantly associated with the presence of antibodies against cVim (odds ratio [OR] 4.95, 95% confidence interval [95% CI] 1.87–15.3) and were not significantly associated with the presence of antibodies against cFibr (OR 1.71, 95% CI 0.70–4.14). These results were replicated in the second cohort (OR 5.05, 95% CI 1.92–13.6 and OR 1.19, 95% CI 0.30–3.97, respectively).

Conclusion

In 2 cohorts of ACPA‐positive patients with RA, SE alleles predisposed for the development of antibodies against cVim but not for the development of antibodies against cFibr. These data indicate that SE alleles act as “classic” immune response genes in the ACPA response, because they influence both the magnitude and the specificity of this RA‐specific antibody response.
British isles lupus assessment group 2004 index is valid for assessment of disease activity in systemic lupus erythematosus
Authors: Yee Chee‐Seng , Farewell Vernon , Isenberg David A. , Rahman Anisur , Teh Lee‐Suan , Griffiths Bridget , Bruce Ian N. , Ahmad Yasmeen , Prabu Athiveeraramapandian , Akil Mohammed , McHugh Neil , D'Cruz David , Khamashta Munther A. , Maddison Peter , Gordon Caroline
Published: November 2007

Objective

To determine the construct and criterion validity of the British Isles Lupus Assessment Group 2004 (BILAG‐2004) index for assessing disease activity in systemic lupus erythematosus (SLE).

Methods

Patients with SLE were recruited into a multicenter cross‐sectional study. Data on SLE disease activity (scores on the BILAG‐2004 index, Classic BILAG index, and Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI‐2K]), investigations, and therapy were collected. Overall BILAG‐2004 and overall Classic BILAG scores were determined by the highest score achieved in any of the individual systems in the respective index. Erythrocyte sedimentation rates (ESRs), C3 levels, C4 levels, anti–double‐stranded DNA (anti‐dsDNA) levels, and SLEDAI‐2K scores were used in the analysis of construct validity, and increase in therapy was used as the criterion for active disease in the analysis of criterion validity. Statistical analyses were performed using ordinal logistic regression for construct validity and logistic regression for criterion validity. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated.

Results

Of the 369 patients with SLE, 92.7% were women, 59.9% were white, 18.4% were Afro‐Caribbean and 18.4% were South Asian. Their mean ± SD age was 41.6 ± 13.2 years and mean disease duration was 8.8 ± 7.7 years. More than 1 assessment was obtained on 88.6% of the patients, and a total of 1,510 assessments were obtained. Increasing overall scores on the BILAG‐2004 index were associated with increasing ESRs, decreasing C3 levels, decreasing C4 levels, elevated anti‐dsDNA levels, and increasing SLEDAI‐2K scores (all P < 0.01). Increase in therapy was observed more frequently in patients with overall BILAG‐2004 scores reflecting higher disease activity. Scores indicating active disease (overall BILAG‐2004 scores of A and B) were significantly associated with increase in therapy (odds ratio [OR] 19.3, P < 0.01). The BILAG‐2004 and Classic BILAG indices had comparable sensitivity, specificity, PPV, and NPV.

Conclusion

These findings show that the BILAG‐2004 index has construct and criterion validity.
Association of an IRF5 gene functional polymorphism with Sjögren's syndrome
Authors: Miceli‐Richard Corinne , Comets Emmanuelle , Loiseau Pascale , Puechal Xavier , Hachulla Eric , Mariette Xavier
Published: November 2007

Objective

Interferon regulatory factor 5 (IRF‐5) is a transcription factor involved in the regulation of the host defense. Previous studies have demonstrated a significant association of various IRF5 gene polymorphisms with systemic lupus erythematosus (SLE) in Caucasians. The purpose of this case–control study was to investigate whether IRF5 polymorphisms are involved in the genetic predisposition to primary Sjögren's syndrome (SS), an autoimmune disease closely related to SLE.

Methods

We analyzed IRF5 rs2004640, rs2070197, rs10954213, and rs2280714 polymorphisms in a cohort of 212 primary SS patients and 162 healthy blood donors, all of whom were of Caucasian origin. The 4 polymorphisms examined were genotyped by competitive allele‐specific polymerase chain reaction using fluorescence resonance energy transfer technology.

Results

The IRF5 rs2004640 GT or TT genotype (T allele carriers) was identified in 87% of primary SS patients compared with 77% of controls (P = 0.01, odds ratio [OR] 1.93 [95% confidence interval (95% CI) 1.15–3.42]). The IRF5 rs2004640 T allele was found on 59% of chromosomes from primary SS patients compared with 52% of chromosomes from controls (P = 0.04, OR 1.36 [95% CI 1.01–1.83]). No significant association of primary SS with rs2070197, rs10954213, or rs2280714 was seen when they were analyzed independently. Nevertheless, haplotype reconstructions based on the 4 polymorphisms examined suggest that various allele combinations of rs2004640 and rs2070197 could define susceptibility or protective haplotypes.

Conclusion

This study is the first to demonstrate a significant association between primary SS and the IRF5 rs2004640 T allele. These results, which require further replication on larger populations, suggest that besides their association with identical major histocompatibility complex gene polymorphisms, primary SS and SLE share IRF gene polymorphisms as a common genetic susceptibility factor.
Craniosynostosis and maternal smoking
Authors: Carmichael Suzan L. , Ma Chen , Rasmussen Sonja A. , Honein Margaret A. , Lammer Edward J. , Shaw Gary M.
Published: November 2007

BACKGROUND: Several previous studies suggested increased risk of craniosynostosis among infants born to women who smoked. METHODS: This study used data from the National Birth Defects Prevention Study, a multi‐state, population‐based case‐control study of infants delivered from 1997–2003. Nonmalformed, liveborn controls were selected randomly from birth certificates or birth hospitals. Data from maternal telephone interviews were available for 531 cases and 5008 controls. RESULTS: Smoking during the first month of pregnancy was not associated with craniosynostosis. Smoking later in pregnancy was associated with increased risk, but only among mothers who smoked at least one pack/day. For example, during the second trimester, the odds ratio for smoking <5 cigarettes/day was 1.0 (95% confidence interval [CI] 0.6, 1.8), but the odds ratio (OR) for smoking 15 or more cigarettes/day was 1.6 (95% CI 0.9, 2.8), after adjustment for maternal age, education, race‐ethnicity, sub‐fertility, parity, folic acid supplement intake, body mass index, and study center. Among women who did not smoke, adjusted odds ratios suggested that secondhand smoke exposure at home, but not at work/school, was associated with modestly increased risk; the OR for home exposure was 1.3 (95% CI 0.9, 1.9). Results followed a similar pattern for some, but not all, specific suture types, but numbers for some groupings were small. CONCLUSIONS: The results suggest moderately increased risk of craniosynostosis among mothers who were the heaviest smokers and who continued to smoke after the first trimester. Results are somewhat equivocal, given that most confidence intervals included one. Birth Defects Research (Part A), 2008. © 2007 Wiley‐Liss, Inc.
The role of service delivery non governmental organisations in policy reform
Authors: Harwin Judith , Barron Tanya
Published: November 2007

This article considers the role of non‐governmental organisations (NGOs) in supporting the development of policy to enhance child welfare and protection services. It examines some of the opportunities and barriers which exist for small‐scale service–delivery organisations to contribute effectively to policy formulation and explores opportunities for the development of this capacity. The discussion is illustrated by specific reference to the role of the NGOs in southeastern Europe, the Former Soviet Union and Central Asia. Copyright © 2007 John Wiley & Sons, Ltd.
Analysis of bifurcation lesions treated with novel drug‐eluting dedicated bifurcation stent system: Intravascular ultrasound results of the AXXESS PLUS trial
Authors: Miyazawa Akiyoshi , Ako Junya , Hassan Ali , Hasegawa Takao , Abizaid Alexandre , Verheye Stefan , McClean Dougal , Neumann Franz J. , Grube Eberhard , Honda Yasuhiro , Fitzgerald Peter J.
Published: November 2007

Objective:

The aim of this intravascular ultrasound (IVUS) study was to assess the efficacy of the AXXESS Plus stent system for the treatment of bifurcation coronary lesions.

Background:

The AXXESS Plus is a novel bifurcation drug‐eluting stent, comprised of a self‐expanding flare‐shaped stent platform and bioabsorbable polymer coating that releases Biolimus A9.

Methods:

Data were obtained from the AXXESS PLUS trial, a prospective, multicenter, nonrandomized, single‐arm study to evaluate safety and efficacy. Six‐month follow‐up IVUS analysis was available in 49 cases. Volumetric analysis using Simpson's method within the AXXESS stent, and cross‐sectional analysis at the ostium of main branch and/or side branch was performed. Impact of bifurcation angle on stent expansion at the carina was also evaluated. Results: Within the AXXESS stent, neointimal volume obstruction percentage was 2.3% ± 2.2%, with a minimum lumen area of 7.9 ± 2.6 mm2. Lumen area was 5.2 ± 1.7 mm2 at main branch ostium, and 4.0 ± 1.5 mm2 at side branch ostium. In two cases, incomplete stent apposition was observed at the proximal edge of the AXXESS stent. In one case, a gap between the AXXESS stent and an additional stent was observed. Greater bifurcation angle inversely correlated with smaller stent area at side branch ostium (r = −0.54, P = 0.03) but not at main branch ostium (r = −0.2, P = 0.29).

Conclusions:

This novel self‐expanding, drug‐eluting bifurcation stent demonstrated effective lesion coverage along with significant neointimal suppression equivalent to current generation balloon‐expandable drug‐eluting stent technology. © 2007 Wiley‐Liss, Inc.
Preparation, Crystal Structure and Thermal Expansion of a New Bismuth Barium Borate, BaBi2B4O10.
Authors: Bubnova R. S. , Krivovichev S. V. , Filatov S. K. , Egorysheva A. V. , Kargin Y. F.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Structure, Optical Properties, and Electronic Structure of NaLiCdS2.
Authors: Deng Bin , Chan George H. , Huang Fu Qiang , Gray Danielle L. , Ellis Donald E. , Van Duyne Richard P. , Ibers James A.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structural Modulation in K2V3O8.
Authors: Chakoumakos B. C. , Custelcean R. , Kamiyama T. , Oikawa K. , Sales B. C. , Lumsden M. D.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Relationship Between the Thermal Expansions and Structures of ABO4 Oxides.
Authors: Li Huiling , Zhou Shihong , Zhang Siyuan
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation and Visible‐Light Photocatalytic Activity of Ag3VO4 Powders.
Authors: Hu Xuexiang , Hu Chun
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Crystal and Band Structures, and Properties of a New Supramolecular Complex (Hg2As)2(CdI4).
Authors: Zou Jian‐Ping , Wu Dong‐Sheng , Huang Shu‐Ping , Zhu Jing , Guo Guo‐Cong , Huang Jin‐Shun
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Low‐Alkali Metal Content in β‐Vanadium Mixed Bronzes: The Crystal Structures of β‐Kx(V,Mo)6O15 (x = 0.23 and 0.32) by Single‐Crystal X‐Ray Diffraction.
Authors: Zema Michele , Ghigna Paolo , Tarantino Serena C.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrothermal Synthesis, Structure and Thermal Stability of Diamine Templated Layered Uranyl‐Vanadates.
Authors: Rivenet Murielle , Vigier Nicolas , Roussel Pascal , Abraham Francis
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Comparative High‐Pressure Study and Chemical Bonding Analysis of Rh3Bi14 and Isostructural Rh3Bi12Br2.
Authors: Gu Q. F. , Krauss G. , Grin Yu. , Steurer W.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Growth of New Ternary Intermetallic Phases from Ca/Zn Eutectic Flux.
Authors: Stojanovic Milorad , Latturner Susan E.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Catalyzed Regio‐ and Diastereoselective Allylic Alkylation Using 2‐(Diphenylphosphino)benzoic Acid: Construction of Vicinal Quaternary and Tertiary Carbon Centers.
Authors: Kawatsura Motoi , Ikeda Daiji , Komatsu Yuji , Mitani Kana , Tanaka Takeshi , Uenishi Junichi
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Internal Delivery of Soft Chlorine and Bromine Atoms: Stereoselective Synthesis of (E)‐β‐Halogenovinyl(aryl)‐λ3‐iodanes Through Domino λ3‐Iodanation—1,4‐Halogen Shift—Fluorination of Alkynes.
Authors: Ochiai Masahito , Hirobe Masaya , Yoshimura Akira , Nishi Yoshio , Miyamoto Kazunori , Shiro Motoo
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tetrafluoro‐IBA and IBX: Hypervalent Iodine Reagents.
Authors: Richardson Robert D. , Zayed Jameel M. , Altermann Sabine , Smith Daniel , Wirth Thomas
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
SeO2/H2O2/H2O‐Dioxane: A New Catalytic System for trans Dihydroxylation of Olefins.
Authors: Gogoi Pranjal , Sharma Saikat Das , Konwar Dilip
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dechalcogenative Allylic Selenosulfide and Disulfide Rearrangements: Complementary Methods for the Formation of Allylic Sulfides in the Absence of Electrophiles. Scope, Limitations, and Application to the Functionalization of Unprotected Peptides in Aqueous Media.
Authors: Crich David , Krishnamurthy Venkataramanan , Brebion Franck , Karatholuvhu Maheswaran , Subramanian Venkataraman , Hutton Thomas K.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Iron‐Catalyzed Cross‐Coupling of Alkyl Halides with Alkenyl Grignard Reagents.
Authors: Guerinot Amandine , Reymond Sebastien , Cossy Janine
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of Macrocyclon Analogues: Calix[8]arenes with Extended Polyethylene Glycol Chains.
Authors: Loiseau Francois A. , Hill Alison M. , Hii King Kuok
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactions of Alanes and Aluminates with Tri‐Substituted Epoxides. Development of a Stereospecific Alkynylation at the more Hindered Carbon.
Authors: Zhao Hongda , Engers Darren W. , Morales Christian L. , Pagenkopf Brian L.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Coupling of Butylvinyltellurides with Organometallic Reagents Catalyzed by Nickel Complexes.
Authors: Raminelli Cristiano , Gargalaka Joao Jr. , Silveira Claudio C. , Comasseto Joao V.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Synthesis of 1,2‐Amino Alcohols by [2,3]‐Wittig Rearrangements.
Authors: Barbazanges Marion , Meyer Christophe , Cossy Janine
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Henry Reaction Catalyzed with Copper(II)—Iminopyridine Complexes.
Authors: Blay Gonzalo , Climent Estela , Fernandez Isabel , Hernandez‐Olmos Victor , Pedro Jose R.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Mild and Efficient Synthesis of β‐Amino Alcohols from Epoxides Using a Mesoporous Aluminosilicate Catalyst.
Authors: Robinson Mathews W. C. , Timms David A. , Williams Sarah M. , Graham Andrew E.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Indium—Bipyridine Catalyzed, Enantioselective Aminolysis of meso‐Epoxides.
Authors: Mai Enzo , Schneider Christoph
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Solvent‐Controlled Highly Efficient Pd—C Catalyzed Hydrogenolysis of Benzaldehydes to Methylbenzenes via a Novel “Acetal Pathway”.
Authors: Xing Lixin , Wang Xinyan , Cheng Chuanjie , Zhu Rui , Liu Bo , Hu Yufei
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Access to Orthoquinols and Their [4 + 2] Cyclodimers via SIBX‐Mediated Hydroxylative Phenol Dearomatization.
Authors: Lebrasseur Nathalie , Gagnepain Julien , Ozanne‐Beaudenon Aurelie , Leger Jean‐Michel , Quideau Stephane
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Metal‐Free One‐Pot Oxidative Amination of Aldehydes to Amides.
Authors: Ekoue‐Kovi Kekeli , Wolf Christian
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Alkoxycarbonylation Reactions Performed Using Near‐Stoichiometric Quantities of CO.
Authors: Kormos Chad M. , Leadbeater Nicholas E.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Naproxen Derivatives: Lewis Acid/Transition‐Metal Free Synthesis via C—C Bond Forming Reaction.
Authors: Pal Sarbani , Bindu P. , Venna Pragnyadhar Reddy , Dubey P. K.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regio‐ and Stereoselective Lithiation of Terminal Oxazolinylaziridines: The Aziridine N‐Substituent and the Oxazolinyl Group Effect.
Authors: Luisi Renzo , Capriati Vito , Di Cunto Peppino , Florio Saverio , Mansueto Rosmara
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reaction of β‐Lactam Carbenes with Alkyl Isonitriles for a Ready Approach to 4‐Cyano and 4‐Carbamoyl Substituted β‐Lactams.
Authors: Cheng Lan‐Qing , Cheng Ying
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
SiO3‐Supported CeCl3×7H2O—NaI Lewis Acid Promoter: Investigation into the Garcia Gonzalez Reaction in Solvent‐Free Conditions.
Authors: Bartoli Giuseppe , Fernandez‐Bolanos Jose G. , Di Antonio Giustino , Foglia Gioia , Giuli Sandra , Gunnella Roberto , Mancinelli Michele , Marcantoni Enrico , Paoletti Melissa
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Pyrazolo[1,5‐a]indoles via Copper(I)‐Catalyzed Intramolecular Amination.
Authors: Zhu Yong‐Ming , Qin Lie‐Na , Liu Rui , Ji Shun‐Jun , Katayama Hajime
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Three Multicomponent Reactions of 3,5‐Dimethyl‐4‐nitroisoxazole.
Authors: Adamo Mauro F. A. , Konda Vivekananda R. , Donati Donato , Sarti‐Fantoni Piero , Torroba Tomas
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cinchona Alkaloid Based Thiourea Promoted Enantioselective Conjugate Addition of N‐Heterocycles to Enones.
Authors: Wang Jian , Zu Liansuo , Li Hao , Xie Hexin , Wang Wei
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Dibenzo[b,d]pyran‐6‐ones Based on [3 + 3] Cyclizations of 1,3‐Bis(silyl enol ethers) with 3‐Silyloxy‐2‐en‐1‐ones.
Authors: Hussain Ibrar , Nguyen Van Thi Hong , Yawer Mirza Arfan , Dang Tuan Thanh , Fischer Christine , Reinke Helmut , Langer Peter
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Efficient and Versatile Approach for the Immobilization of Carbene Precursors via Copper‐Catalyzed [3 + 2]‐Cycloaddition and Their Catalytic Application.
Authors: Zeitler Kirsten , Mager Ina
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oxidation of Methyl Heteroaryls with Molecular Oxygen: A Facile Synthesis of 2‐[N‐(tert‐Butoxycarbonyl)amino]‐4‐pyridinecarbaldehyde.
Authors: Berlin Michael , Aslanian Robert , de Lera Ruiz Manuel , McCormick Kevin D.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regioselecive Synthesis of Novel Polyfunctionally Substituted Pyrazolo[1,5‐a]pyrimidines under Solvent‐Free Conditions.
Authors: Quiroga Jairo , Portilla Jaime , Abonia Rodrigo , Insuasty Braulio , Nogueras Manuel , Cobo Justo
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Three‐Component Coupling of a Silylene, Aldehydes and Electron‐Deficient Acetylenes via 1,3‐Dipolar Cycloaddition.
Authors: Minakata Satoshi , Ohashi Seishi , Amano Yusuke , Oderaotoshi Yoji , Komatsu Mitsuo
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Model Studies Toward the Synthesis of the Bioactive Diterpenoid Harringtonolide (I).
Authors: O'Sullivan Timothy P. , Zhang Hongbin , Mander Lewis N.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of Efficient Methods for Accomplishing Cysteine‐Free Peptide and Glycopeptide Coupling.
Authors: Chen Gong , Wan Qian , Tan Zhongping , Kan Cindy , Hua Zihao , Ranganathan Krishnakumar , Danishefsky Samuel J.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Approaches for the Synthesis and Activation of Thio‐ and Selenoglycoside Donors.
Authors: Valerio Silvia , Iadonisi Alfonso , Adinolfi Matteo , Ravida Alessandra
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Cyclophospho‐Glucoses and Glucitols.
Authors: Amigues E. J. , Greenberg M. L. , Ju S. , Chen Y. , Migaud M. E.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of (‐)‐Lapatin B.
Authors: Walker Steven J. , Hart David J.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Route to Platensimycin: An Intramolecular Robinson Annulation Approach.
Authors: Li Pingfan , Payette Joshua N. , Yamamoto Hisashi
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Monodictyquinone A: A New Antimicrobial Anthraquinone from a Sea Urchin‐Derived Fungus Monodictys sp.
Authors: El‐Beih Ahmed Atef , Kawabata Tetsuro , Koimaru Keiichiro , Ohta Tomihisa , Tsukamoto Sachiko
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Fast and Efficient Synthesis of the Complete LL‐Z1640‐2 Framework.
Authors: Henry Neil , Robertson Murray N. , Marquez Rodolfo
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Short Synthesis of Piperizinohydroisoquinoline Ring by Selective Pictet—Spengler Cyclization and Evaluation of Antitumor Activity.
Authors: Chang Yu‐An , Sun Tsung‐Hsien , Chiang Michael Y. , Lu Pei‐Jung , Huang Yi‐Ting , Liang Li‐Ching , Ong Chi Wi
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Complex Hydrides for Hydrogen Storage
Authors: Orimo Shin‐ichi , Nakamori Yuko , Eliseo Jennifer R. , Zuettel Andreas , Jensen Craig M.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrogen Storage in Molecular Clathrates
Authors: Struzhkin Viktor V. , Militzer Burkhard , Mao Wendy L. , Mao Ho‐kwang , Hemley Russell J.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Use of Fluorine for the Synthesis of Crystalline Microporous Compounds
Authors: Loiseau Thierry , Ferey Gerard
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Biocatalysis in Non‐Conventional Media‐Ionic Liquids, Supercritical Fluids and the Gas Phase
Authors: Cantone Sara , Hanefeld Ulf , Basso Alessandra
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Synopsis on Different Homologous Series of Fomocaine Derivatives
Authors: Lupp Amelie , et al. et al.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Two Highly Effective Phase‐Transfer Catalysts for the Enantioselective Synthesis of α‐Amino Acid Derivatives
Authors: Lygo Barry , Beaumont Douglas J.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Depsipeptide Synthesis
Authors: Stawikowski Maciej , Cudic Predrag
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Asymmetric Synthesis of the Anti‐influenza Neuraminidase Inhibitor Oseltamivir (Tamiflu)
Authors: Behera Manoranjan
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Revisitation of Cycloheptatriene Derivatives as a Building Block for Various Substituted and Fused 1,6‐Methano[10]annulenes and Substituted 4,9‐Methanothia[11]annulenes
Authors: Kuroda Shigeyasu , Kajioka Takanori , Fukuta Atsushi , Thanh Nguyen Chung , Zhang Yanmei , Miyatake Ryuta , Mouri Masaru , Zuo Shengli , Oda Mitsunori
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy
Authors: Famulok Michael , Hartig Joerg S. , Mayer Guenter
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Micro‐Reactors for PET Tracer Labeling
Authors: Lu S. Y. , Pike V. W.
Published: November 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Numerical modelling of hydro‐mechanical behaviour of collapsible soils
Authors: Costa L. M. , Pontes I. D. S. , Guimarães L. J. N. , Ferreira S. R. M.
Published: November 2007

This paper presents a numerical simulation of the response of unsaturated soil under different loads, with special attention devoted to the phenomenon of pore collapse during wetting. A coupled hydro‐mechanical formulation, implemented in the computational code CODE_BRIGHT, is first presented. Then the model is applied to assess material parameter from laboratory tests and to simulate, as boundary value problems, new and appealing in situ tests designed in the Federal University of Pernambuco. The soil considered is a collapsible soil located in the semi‐arid region of the northeast of Brazil. Two situations are analysed: (i) the soil is initially at its natural water content and then flooded at some determined stress level, (ii) the soil is previously flooded and then loaded. Comparison between output results of numerical simulations and experimental data shows a very good agreement, which validate to some extent the proposed experimental procedure and the model formulation. Copyright © 2007 John Wiley & Sons, Ltd.
Space–time discontinuous Galerkin method for dynamics of solids
Authors: Aksoy H. G. , Şenocak E.
Published: November 2007

In this study, a space–time discontinuous Galerkin formulation is derived for dynamic analysis of solids. Numerical implementation of proposed formulation is presented, and numerical examples are provided for shock wave propagation problems. Numerical results are compared with that of the known exact solutions of the problems and numerical results obtained from a commercial finite element code. The proposed space–time discontinuous Galerkin formulation is found to be robust and successful in modelling transient problems, i.e. shock wave propagation problems. Copyright © 2007 John Wiley & Sons, Ltd.
Natural killer T cells and innate immune B cells from lupus‐prone NZB/W mice interact to generate IgM and IgG autoantibodies
Authors: Takahashi Tsuyoshi , Strober Samuel
Published: November 2007

Lupus‐prone NZB/W F1 mice develop glomerulonephritis after T helper cell‐dependent isotype switching of autoantibody secretion from IgM to IgG at about 6 months of age. We compared innate immune natural killer (NK) T cells and conventional T cells for their capacity to help spontaneous in vitro immunoglobulin and autoantibody secretion of innate immune (B‐1 and marginal zone) and conventional (follicular) B cell subsets from NZB/W F1 mice. We found that purified NKT cells not only increased spontaneous secretion of IgM and IgM anti‐double‐stranded (ds)DNA antibodies by B‐1 and marginal zone B cells, but also facilitated secretion of IgG anti‐dsDNA antibodies predominantly by B‐1 B cells. Few IgM or IgG anti‐dsDNA antibodies were secreted by follicular B cells, and conventional T cells failed to provide potent helper activity to any B cell subset. All combinations of T and B cell subsets from normal C57BL/6 mice failed to generate vigorous IgM and IgG secretion. NZB/W NKT cell helper activity was blocked by anti‐CD1 and anti‐CD40L mAb. In conclusion, direct interactions between innate immune T and B cells form a pathway for the development of IgM and IgG lupus autoantibody secretion in NZB/W mice.
Running to stand still: BCR‐like signaling suppresses type I IFN responses in pDC
Authors: Swiecki Melissa K. , Colonna Marco
Published: November 2007

Plasmacytoid dendritic cells (pDC) specialize in the secretion of type I interferon (IFN). Although multiple pathways that modulate type I IFN responses have been described they are inadequately defined. In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)‐like signaling cascade in pDC that suppresses type I IFN production is provided.

See accompanying article: http://dx.doi.org/10.1002/eji200737711
Cover Picture: Autoreactive B cells get activated in extrafollicular sites – Eur. J. Immunol. 12/2007
Authors: Weisel Florian , Wellmann Ute , Winkler Thomas H.
Published: November 2007

The cover image schematically depicts the mechanisms proposed by Winkler and colleagues (pp. 3330–3333) as underlying the extrafollicular activation of rheumatoid factor B cells by chromatin–immune complexes. The follicular region is shown in orange, the marginal sinus in green, the marginal zone in turquoise, and the red pulp in red. The scheme is based on the data obtained by Shlomchik and colleagues (pp. 3339–3351) in their new mouse model of extrafollicular somatic hypermutation, a characteristic of murine lupus. The model importantly uses IgG anti‐chromatin antibodies rather than conventional immune complexes.
Electrochemical Detection of DNA Hybridization Based on the Probe Labeled with Carbon‐Nanotubes Loaded with Silver Nanoparticles
Authors: Gao Mei , Qi Honglan , Gao Qiang , Zhang Chengxiao
Published: November 2007

A sensitive electrochemical method for the detection of DNA hybridization based on the probe labeled with multiwall carbon‐nanotubes (MWNTs) loaded with silver nanoparticles (Ag‐MWNTs) has been developed. MWNTs were electroless‐plated with a large number of silver nanoparticles to form Ag‐MWNTs. Probe single strand DNA (ss‐DNA) with a thiol group at the 3′‐terminal labeled with Ag‐MWNTs by self‐assembled monolayer (SAM) technique was employed as an electrochemical probe. Target ss‐DNA with a thiol group was immobilized on a gold electrode by SAM technique and then hybridized with the electrochemical probe. Binding events were monitored by differential pulse voltammetric (DPV) signal of silver nanoparticles. The signal difference permitted to distinguish the match of two perfectly complementary DNA strands from the near perfect match where just three base pairs were mismatched. There was a linear relation between the peak current at +120 mV (vs. SCE) and complementary target ss‐DNA concentration over the range from 3.1×10−14 to 1.0×10−11 mol/L with a detection limit of 10 fmol/L of complementary target ss‐DNA. The proposed method has been successfully applied to detection of the DNA sequence related to cystic fibrosis. This work demonstrated that the MWNTs loaded with silver nanoparticles offers a great promising approach for sensitive detection of DNA hybridization.
Disposable Gold Electrode Array for Simultaneous Electrochemical Studies
Authors: Priano Graciela , González Graciela , Günther Mauricio , Battaglini Fernando
Published: November 2007

An efficient and inexpensive eight gold electrode array has been manufactured by a combination of screen printing and gold electrodeposition techniques. Gold electrodeposition was performed in potentiostatic and galvanostatic conditions. Different treatments, involving temperature and polishing control, led to electrodes with different roughness. The electrochemical behavior of the generated gold surface was studied by cyclic voltammetry showing the characteristic response of polycrystalline gold, in contrast with disposable gold electrodes fabricated by screen printing from gold inks. The electrodes were chemically modified through the adsorption of alkanethiols self‐assembled monolayers and the coupling of a model protein. Both reactions were followed by cyclic voltammetry and Electrochemical Impedance Spectroscopy (EIS). The electrodes have shown high reproducibility in their electrochemical behavior as well as in their modifications.