bluuebunny/crossref_metadata_2025 huggingface dataset:
036. Sclerotic Therapy as The Management Of Arteriovenous Malformation on Hand: A Case Report
Authors: Arnaya Agung Aditya , Wibawa IGAB Krisna
Published: November 2024

Background: An arteriovenous malformation (AVM) is an abnormal connection between arteries and veins, bypassing the capillary system. There are a number of consequences associated with this illness, such as bleeding and neurological impairments. The situation is complex, which emphasizes the necessity for individualized treatment plans. This case report a 18 years old female with AVM condition. Case: A 18 years old female was admitted to to Prof. IGNG Ngoerah General Hospital with a chief complaint of lump on the left finger. The lump on the left finger has been felt since >10 years ago. The lump appeared suddenly and went bigger each day. Complaints worsened until the patient felt pain in the left finger. On examination of the local status, multiple masses were found on third and fourth digits of the left hand, with unclear border and vein ectasis. MSCT Angiography of the left superior extremity found a soft tissue image of hemangioma on the palmar aspect and interdigiti III-IV to the palmar-dorsal aspect of digit III and the palmar aspect of digiti IV of the left hand and multiple non-suspicious lymphadenopathy in the left axilla region. The scleroterapy treatment was performed and 3 months results shown decreased size of the masses without any complication. Conclusion: An arteriovenous malformation (AVM) of the left hand fingers is a rare case found in Prof Ngoerah Hospital. The sclerotic therapy found to be an effective management for this case.
040. Survival Rate of Colorectal Cancer Patients at Dr. Zainoel Abidin General Hospital 2021-2023
Authors: Romi Romi
Published: November 2024

Background: Cancer is one of the most common cause of mortality worldwide. From the statistic, the mortality case of the Colorectal Cancer increases over 77% a year. In indonesia, the incidence of Colorectal Cancer was high. However, profile data and survival rates are still rarely reported in Indonesia, especially Aceh. The aim of this study were to determine the survival rate of Colorectal Cancer patients and also to obtain the profile data based on age, gender and clinical categories in Dr. Zainoel Abidin Hospital, Aceh Indonesia. Methods: This study was an observational descriptive study with a cross-sectional approach. The data used in this study is patient's medical record according to the inclusion criteria, using 104 medical records of Colorectal Cancer patients for the period 2021-2023. Data were analyzed with univariate data analysis by SPSS. Results: Among 104 Colorectal Cancer patients, man were the most frequent demographical findings. There is (80,8%) CRC occur at age more than 40 years and most of the patients diagnosed in stage 4. Survival rate of Colorectal Cancer patient on this study mostly more than 1 year. Conclusion: The conclusion of this study is that gender, the age of patient and the Cancer stage have a significant relationship each other and also influenced the survival rate of patients.
042. Colonic Duplication with Recto-Vestibular Fistula: A Case Report
Authors: Fitriansyah Muhammad Noor , Soenjoto Dadik Agus
Published: November 2024

Background: Anorectal malformations associated with colonic duplications are a rare condition. Colonic duplication may have different presentations according to its location and size, with an incidence of less than 15% of all gastrointestinal duplications. Colonic duplication is less common than ileal duplication, whether cystic or tubular. Duplications are considered congenital malformations because they are thought to arise from disturbances in embryonic development. This report aims to present and analyze the clinical presentation, diagnostic approach, and management of anorectal malformations associated with colonic duplications in an 11-month-old child at our hospital, highlighting the challenges and treatment strategies for such a rare case. Case: We present a case of an 11-month-old girl, referred from a network hospital with a post-colostomy at 4 months of age for recto-vestibular fistula with findings of colonic duplications at colostomy. Exploratory laparotomy was performed until the colonic duplications were identified and completely resected. Conclusion: Colonic duplication is a rare congenital disorder, and its association with anorectal abnormalities is even rarer. The surgical treatment includes resection of the duplicated colon. Surgical intervention is the treatment of choice.
043. Multidiciplinary Management of Toxic Megacolon in Ulcerative Colitis: A Case Report and Review of Current Practice
Authors: Kurnianda Ridho , Suswita Rini , Setiawati Yessy
Published: November 2024

Background: Toxic megacolon is a life-threatening condition characterized by extreme colonic dilation and systemic toxicity. It often results from underlying inflammatory bowel disease, such as ulcerative colitis, or infectious colitis. Early recognition and management are crucial to prevent complications such as colonic perforation or sepsis.  Case: We present the case of a 42-year-old male with a history of ulcerative colitis based on histopathology examination who developed toxic megacolon. The patient presented with severe abdominal pain, distension, fever, and signs of systemic toxicity. Imaging studies revealed marked colonic dilation, and laboratory tests indicated elevated inflammatory markers. Initial management included broad-spectrum antibiotics, intravenous corticosteroids, and fluid resuscitation. Despite aggressive medical treatment, the patient’s condition worsened, necessitating surgical intervention. A total colectomy with ileostomy was performed, and the patient’s postoperative course was uncomplicated. Conclusion: This case underscores the importance of early diagnosis and intervention in toxic megacolon. A multidisciplinary approach involving gastroenterologists, surgeons, and intensivists is essential for optimizing patient outcomes. Future research should focus on improving early diagnostic markers and treatment protocols to better manage this critical condition.
050. Surviving Multiple Traumas: A 37-Year-Old Male with Gunshot-Induced Hematopneumothorax and Hollow Organ Perforation
Authors: Manik David Restu P. , Muhar Adi Muradi
Published: November 2024

Background: Traumatic gunshot wounds to the chest and abdomen pose significant challenges in emergency surgical management. This case report presents the rapid diagnosis and successful treatment of a 37-year-old male who sustained gunshot wounds to the chest and abdomen, leading to hematopneumothorax and hollow organ perforation. Case: The patient, a 37-year-old male, was admitted to Adam Malik Hospital with shortness of breath and severe abdominal pain following a gunshot injury to the chest and lower abdomen. On primary survey, the patient exhibited tachypnea (RR 26 tpm) and hypoxia (SpO2 94% on room air), which improved with oxygen therapy. Vital signs were stable, but a left-sided hematopneumothorax and abdominal tenderness suggested hollow organ perforation. Radiological and FAST ultrasound findings confirmed the diagnosis. Emergency chest tube insertion and exploratory laparotomy were performed. The chest tube revealed hemorrhagic effusion, and laparotomy identified two small bowel perforations at 100 cm and 130 cm from the ligament of Treitz, alongside an impaled object in the mesentery. Primary suturing of the perforations was performed, and the abdomen was irrigated thoroughly. Postoperative recovery was uneventful, with the patient showing rapid clinical improvement. Conclusion: Rapid emergency surgical response led to a favorable outcome in a patient with life-threatening thoracoabdominal gunshot wounds, emphasizing the role of timely interventions in trauma care.
056. Impacted CBD Stones in Ampula Vater Evacuated by Transduodenal Approach in A 48-year-old Patient at Prof. Dr. IGNG Ngoerah Hospital in 2024
Authors: Wijaya Komang Soni Wicaksana , Sueta Made Agus Dwianthara
Published: November 2024

Background: Cholecystolithiasis and choledocholithiasis are common biliary disorders that can lead to significant complications if left untreated. Among these complications, the formation of impacted CBD stones, particularly at the Ampulla of Vater, poses a unique clinical challenge. The Ampulla of Vater is the anatomical site where the common bile duct (CBD) and pancreatic duct converge, and its obstruction can lead to biliary colic, cholangitis, or pancreatitis. Urgent stone removal is critical for improving the patient’s condition. Case: A 48-year-old male patient presents to the emergency department with right upper abdominal pain since 10 days ago accompanied with icteric sclera since 10 days ago. There was nausea and vomiting when eating high-fat foods. The stools were brownish in color, the urine color was similar to tea color. The patient regularly takes UDCA 3 x 250 mg IO, simvastatin 1 x 20mg IO, curcuma 3 x1 tab IO, lansoprazole 2 x 30mg IO. Physical examination showed icteric eyes, jaundice, liver enlargement 2 fingers below costae arch with positive Murphy's sign. Complete blood examination showed leukocytosis, decreased hemoglobin, hypokalemia, as well as increased direct bilirubin, total bilirubin, and indirect bilirubin. BOF result showed sentinel loop on the right umbilical region suspected inflammatory process. MRI impression of choledocholithiasis causing dilatation of EHBD and IHBD proximal aspect without signs of cholangitis, hepatomegaly, simple cyst of left kidney (Bosniak I). Abdominal ultrasound with the conclusion of cholecystitis with dilatation and thickening of the ductus cysticus wall suspicious of inflammation, dilatation of the right and left IHBD, common hepatic duct, to the proximal common biliary duct, the presence of distal obstruction cannot be evaluated because it is covered by intestinal shadows, mild prostatic hypertrophy accompanied by prostate calcification. After Cholecystectomy and Explore CBD transduodenal, the patient was placed with thoracic drain with good outcome. Conclusion: The transduodenal approach to evacuating impacted CBD stones at the Ampulla of Vater is a valuable technique that can yield excellent outcomes in select cases. This case report underscores the importance of a tailored approach based on individual patient anatomy and stone characteristics.
059. Comparison of Surgical Outcomes Between Robot-Assisted Versus Laparoscopic Distal Pancreatectomy for Resectable Pancreatic Cancer: A Systematic Review and Meta-Analysis
Authors: Diatmika I Kadek Dwi Putra , Mulyawan I Made
Published: November 2024

Background: Background: Distal pancreatectomy is the conventional intervention for neoplasms located in the body and tail of the pancreas. In recent years, robot-assisted distal pancreatectomy (RDP) and laparoscopic distal pancreatectomy (LDP) have gained traction, nevertheless, comparative multicenter studies validating the safety and efficacy of RDP are insufficient. This systematic review and meta-analysis seeks to compare the surgical outcomes of robot-assisted distal pancreatectomy (RPD versus laparoscopic distal pancreatectomy (LPD). Methods: We conducted a search of PubMed, Embase, and the Cochrane Library to discover papers and trials published between 2019 and 2024. The findings of this study encompassed operation duration, intraoperative bleeding and postoperative pancreatic fistula. We utilized Revman 5.4.2 to do the meta-analysis. Results: Eight studies were analyzed, involving 1,085 patients, with 436 getting robot-assisted distal pancreatectomy and 649 undergoing laparoscopic distal pancreatectomy. Our data indicate that robot-assisted distal pancreatectomy is linked with a reduction in operative time, with a mean difference (MD) of 20.67 (95% CI [4.73, 36.61], p = 0.01), and a decrease in intra-operative blood loss, with an MD of -23.43 (95% CI [-36.14, -10.73], p = 0.0003). Our findings indicate that robot-assisted distal pancreatectomy is related with an increased risk of postoperative pancreatic fistula formation, with a relative risk of 1.16 (95% CI [0.84, 1.61], p = 0.36). Conclusion: This study indicated that robot-assisted distal pancreatectomy was associated with decreased operational duration and intraoperative hemorrhage. Further research is needed to corroborate these findings.
062. Satisfying Outcome of 24-Hours Post Operation Feeding Following Bowel Anastomosis Surgery: A Systematic Review and Meta-Analysis
Authors: Rufina Angeline , Zuhan Arif
Published: November 2024

Background: Gastrointestinal anastomosis surgery does not have standardized postoperative feeding practices. The majority of surgeons used to believe that early enteral feeding (EEF) after bowel resection and anastomosis could be harmful and cause stress on the anastomosis site, increasing the risk of leakage. This study compared EEF patients whose nutrition started for the first 24 hours with delayed enteral feedings (DEF) during bowel anastomosis surgery Case: This systematic review and meta-analysis used the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. All extracted data was presented in the table, summarized narratively, and analyzed statistically using forest plots through a relative risk (RR) with a fixed effect model test. Results: This research included 444 participants from 6 studies, including 196 in the EEF group and 248 in the DEF group. From the analysis, the incidence of leakage, gastrointestinal symptoms of abdominal distention and vomiting, fever, and surgical site infection (SSI) were lower in the EEF group although not significant, with statistical values in order namely; leakage (RR 0.39, p=0.10); abdominal distention (RR 0.67, p=0.11), vomiting (RR 0.88, p=0.53); fever (RR 0.61, p=0.005) and SSI (RR 0.42; p=0.002). Length of stay (LOS) was found to be statistically significant shortened in the EEF group (Mean Difference 2.23 days; P < 0.00001). Conclusion: The EEF group had a statistically insignificant lower incidence of leakage, gastrointestinal symptoms, fever, and SSI and statistically significant shorter LOS. Twenty-four hours post-operation enteral feeding showed a satisfactory outcome, so we recommend it in either small or large bowel anastomosis surgery.
067. Report in Delayed Peritonitis Due to Ileal Perforation Due to Abdominal Blunt Trauma in Sardjito Hospital
Authors: Haqim Rijal Maulana , Nirbira Alam , Setyawan Nurcahya
Published: November 2024

Background: Abdominal blunt trauma is a difficult situation, leading to considerable illness and death, particularly in developing nations. The later appearance of symptoms and indicators in these individuals significantly adds to the heightened illness and death rates experienced by the patients. Small bowel perforation following blunt abdominal trauma is an uncommon occurrence, and typically, such cases manifest right after the trauma. Case: We present one case of elderly patient with ileum perforation with Boey Score 2 who showed symptoms on the second day after the injury. We performed ileostomy on the perforation site. We found duodenal perforation 1.5 cm in diameter and 20 cm from ileocecal junction. We refreshed the perforation edge. Patient was in hospital for 5 days and before being discharged. Conclusion: Small bowel perforation is rare, leading to a delay in definitive treatment. Gathering a detailed injury mechanism, observing the patient, conducting thorough investigations using CT and/or FAST, and remaining aware of the potential for small bowel perforation are crucial for successful management of patients with blunt abdominal trauma.
069. Evaluation Quality of Life in Colorectal Cancer Patients After Rectal Resection with Ileostomy
Authors: Farishal Ahmad , Sofii Imam
Published: November 2024

Background: Colorectal cancer where each person has a risk of 1:23 of colorectal and increases according to lifestyle colorectal is the 3rd highest cancer with a prediction of 3.2 billion new cases by 2040. Surgery in the form of resection with ileostomy is performed in up to 95% of cases of colorectal cancer. Quality of life after surgery with ileostomy can be evaluation with EORTC QLQ-C30 and CR29. Methods: Retrospective method with total sampling for 1 year 2023-2024 conducted at Sardjito Hospital, patient data obtained from medical records, questionnaire evaluation using interviews with inclusion criteria. Results: There were first complaints the patient in the form of 54% of bloody stools with the time of complaints range 6 months to 1 year. While 60% of patients came from hospital referrals using government health insurance. The age range is 58 years and dominated by women with BMI status of underweight patients and low education. Tumor borders at 5-10 cm from the anal verse with 75% performed adjuvant chemotherapy and 87% performed colonoscopy. Stage was predominantly stage 3 and adenocarcinoma cancer type up to 65%. EORTC QLQ-C30 and EORTC QLQ-CR29 evaluation results showed differences in emotional functioning at 6 months (p0.04) and decreased body image at 3 months postoperatively (p0.02). There were differences in global quality of life in parts but none in general (p>0.05). Conclusion: Overall, patients experience changes in emotional function at 6 months post and body image at 3 months postoperatively. overall global quality of life scores are no significant.
070. Total Bowel Obstruction and Secondary Renal Impairment Following Bajakah Root Ingestion: Case Report
Authors: Irnawati Farida Dwi , Sulistyo Heru
Published: November 2024

Background: Total bowel obstruction is a critical condition often caused by malignancies and adhesions or rare caused by foreign bodies. The bajakah root is a herbal medicine in Dayak community (Central Kalimantan), traditionally used to treat any diseases. This report presents a unique case of bowel obstruction due to bajakah root, and renal impairment as a complication. Case:  A 62 years old female without any psychiatric disorders with history bajakah root consumtion complaint difficult defecation and green vomiting. Physical examination showed abdominal distention with collapsed rectal ampulla. Laboratory results revealed renal impairment. Imaging studies confirmed total bowel obstruction. Exploratory laparotomy identified ileoileal and ileo-omental adhesions with 0.5x0,5 cm ileum perforation 120 cm distal to the ligament of Treitz and a 2x2 cm wooden foreign body 10 cm distal from the perforation site. Surgical management included adhesiolysis, wedge excision of the ileum, foreign body extraction and anastomosis. Conclusion: Total bowel obstruction, renal impairment, bajakah, foreign body, foreign body extraction.
071. Pantaloon Hernia with Bladder Herniation: A Case Report And Review Of Literature
Authors: Sulistyo Heru , Rosyada Amrina
Published: November 2024

Background: Pantaloon hernias are a rare mix of direct and indirect inguinal hernias on the same side, making them clinically challenging. Bladder herniation, which can occur with pantaloon hernias, adds specific diagnostic and treatment challenges. Inguinal hernias account for about 75% of all abdominal wall hernias and mostly affect men. Case:  A 57-year-old man came to Saiful Anwar Hospital with a left inguinal lump that had been present for six days. He also experienced abdominal swelling, pain, nausea, and vomiting. The lump had become irreducible for the last two days. A physical exam showed a 13x7 cm mass in the left inguinal area. The patient had signs of an inguinal hernia and reported urinary issues, including a feeling of incomplete emptying and urination. Surgery was done on January 13, 2024, using an open technique. During the procedure, the hernia sac had fluid, trapped ileum, and omentum. A part of the bladder was also found protruding through the Inguinal Triangle of Hasselbach, causing a 1x1 cm defect. The hernia sac was repaired with a 10x15 cm mesh. Conclusion: This case highlights the rarity of pantaloon hernias and emphasizes the importance of prompt diagnosis and intervention. Continued research is essential for advancing clinical outcomes and understanding the complexities associated with this condition
072. Subhepatic Appendicitis in A 23 Year Old Woman: A Rare Case Report
Authors: Kartinasari Apidha , Fauzie Rayhan
Published: November 2024

Background: Subhepatic appendicitis is a rare condition that occurs in only 0.01% of all acute appendicitis cases. The subhepatic position of the appendix is due to a developmental anomaly resulting from the failure of the caecum to descend during embryonic development. Its symptoms often resemble those of other diseases such as cholecystitis, pyelonephritis, and urolithiasis, which can lead to a delay in diagnosis and treatment. Case:  A 23-year-old woman presented with four-day history of pain in the right upper quadrant of her abdomen, fever, anorexia, nausea, and vomiting. Abdominal examination revealed tenderness of all abdominal quadrants, which was more pronounced over the right upper and middle quadrant with positive rebound tenderness.  Laboratory tests showed high levels of neutrophilic leukocytosis. Ultrasound imaging revealed an inflamed vermiform appendix in the subhepatic region. A diagnosis of an abnormally located appendix was made, and the patient underwent laparotomy. During exploration, an inflamed appendix was found covered by omentum in the right upper quadrant, and appendectomy was carried out smoothly. The patient was in good clinical condition without any complications. Conclusion: Subhepatic appendicitis presents a significant challenge to clinicians due to its unusual location. Failure to diagnose and manage it promptly can lead to complications such as abscesses, peritonitis, sepsis, and increased morbidity. Midline laparotomy is recommended due to the subhepatic location of the appendix and the possibility of retrocecal, dense adhesion or fibrosis, and perforation, which would make a laparoscopic approach unsafe.
073. Tamoxifen - Associated Hirsutism: An Usual Side Effect in A 52-Year-Old Women with Malignant Neoplasm of Left Breast
Authors: Asri Asri , Abidin Zainal
Published: November 2024

Background: Hirsutism is a condition characterized by growth of excessive male-pattern (i.e., face, chest, abdomen, lower back, upper arms, and thighs) hair  in women. The prevalence of hirsutism has been reported to be between 5% and 15% in women and can be caused by various factors, including the use of medications such as Tamoxifen. The modified Ferriman-Gallwey (mFG) score is the preferred and most widely used method for scoring excess terminal hair in the assessment of hirsutism. This case report aims to explore the relationship between Tamoxifen use and the development of hirsutism, as well as to discuss the potential mechanisms involved. Case:  A 52-year-old female patient was diagnosed with a left breast tumor and underwent neoadjuvant chemotherapy followed by treatment with Tamoxifen 10 mg daily for six months. After treatment, the patient reported abnormal hair growth on her face, chest, arms, and legs. Conclusion: The use of Tamoxifen may contribute to the development of hirsutism in some patients. It is important to monitor these side effects and consider appropriate management strategies for patients experiencing hirsutism related to treatment.
083. Bilateral Mammae Reduction in Patients with Gestational Gigantomastia
Authors: Prasetya I Made Maha , Setiawan Gede Budhi
Published: November 2024

Background: Gestational gigantomastia is a rare clinical condition characterized by rapid and disproportionate breast enlargement during pregnancy. This case report describes a 24-year-old female patient with bilateral gigantomastia. Case: A 24-year-old female patient presented with complaints of a lump in both breasts that had progressively enlarged since her first pregnancy. Physical examination revealed breast enlargement measuring 30x20 cm, with signs of skin stretching, redness, no lesions, and engorged veins around both the left and right breasts. On palpation, there was no tenderness, the tissue felt soft, no masses were detected, and there was retraction of the nipple. In the right and left axillary regions, masses measuring 4x5 cm and 4x3 cm, respectively, were noted, matching the skin color. Breast ultrasound showed diffuse edematous changes in bilateral mammary parenchyma accompanied by duct ectasia, with a differential diagnosis of mastitis. The patient was diagnosed with bilateral gigantomastia and underwent reduction mammoplasty. Conclusion: This case report describes a patient with gestational gigantomastia who underwent reduction mammoplasty and excision of aberrant breast tissue.
096. The Effectiveness of Cardamom Seed Extract (Amomum compactum) Against Urea Creatinine and Histopathology Obese Rat Kidney
Authors: Rifky Fuadhi , Nugroho Eriawan Agung
Published: November 2024

Background: There are several factors that can cause kidney damage, one of which is obesity. Obesity itself can cause complex metabolic disorders that can affect kidney physiology. The biological activity of flavonoid components in A. compactum showed that cardamom extract had high anti-inflammatory and antioxidant activity. This study aimed to analyze the effect of Cardamom Seed Extract (Amomum Compactum) on urea creatinine and histopathology obese rat kidney. Methods: This study was a true experimental with post tests only of control group design and was conducted from July to August 2022 at Pusat Study Pangan dan Gizi (PSPG), Gadjah Mada University. A total of 30 Wistar rats were used in this study and which randomly divided into normal control, negative control, 45 mg dose cardamom, 90 mg dose cardamom, 180 mg dose cardamom groups. Obesity was obtained by high fat and high carbo diet. At the end of the study, the rats will be terminated and urea, creatinine was examined, renal histopathology changes were observed using hematoxylin and eosin strain. Results: There was differences in urea levels between groups K and P1, P2, P3; P1 and P2, P1 and P3, and P2 and P3 (p<0.005). There was differences in creatinine levels between groups K and P1, P2, P3; P1 and P2, and P1 and P3 (p<0.005). There was a significant difference in renal histology between groups normal control, negative control, and P1 (p<0.001). Conclusion: Cardamom seed extract is effective in reducing urea creatinine levels and improving histopathology obese rat kidney.
Mechanisms of Biocontrolling Action of Yeasts in Post-Harvest Fruit: A Review
Authors: Rodrigues Pablo Leal , Galvão Jessivaldo Rodrigues , Maia Bruno Kleidson da Silva , Oliveira Carlos Antônio Marinho Mendonça , Zambrano Maria Isabel Castro , Melo Naiane Franciele Barreira de
Published: November 2024

Objective: The aim of the research is to address the biological control developed by yeasts in the post-harvest of fruits, based on a brief literature review on the subject.
 
Theoretical Framework: The use of chemical control mechanisms and biocontrol is based on the increasing need for sustainable agricultural practices that ensure human health and environmental preservation. While synthetic fungicides are effective in combating fungal diseases, their excessive use raises concerns about pathogen resistance and public health risks. In this context, the development of biocontrol agents, such as yeasts, emerges as a viable and ecological alternative, promoting food safety and crop protection with a lower environmental impact.
 
Method: A narrative literature review was conducted using major scientific databases to collect articles on the biological control of yeasts in the post-harvest of fruits. Key studies were evaluated to measure effectiveness and understand the mechanisms related to the biocontrol action of these yeasts.
 
Results and Discussion: The predominant chemical control for fungal diseases is being replaced by sustainable alternatives, such as yeast-based biofungicides, which demonstrate effectiveness against pathogens in post-harvest settings. Mechanisms such as killer activity and the production of hydrolytic enzymes stand out in biocontrol. Although promising, further research is needed to deepen the understanding of biocontrol agents and their applications.
Inhibition of the Growth of Four Phytopathogenic Fungi by Eucalyptus Wood Vinegar
Authors: Maciel Elen Raquel Ferreira , Silva Elaine Cristina Alves da , Silva Françóyse Dávilla de Souza , Freitas Narjara Walessa Nogueira de , Pimenta Alexandre Santos , Araujo Poliana Coqueiro Dias
Published: November 2024

Purpose: The objective of this work aimed to assess the wood vinegar (WV) from the carbonization of Eucalyptus wood in the inhibition in vitro of Fusarium sp., Ganoderma sp., Macrophomina sp., and Sclerotium rolfsii.
 
Method: WV was added to a culture medium and poured onto Petri dishes. After, the fungi were picked up in 1-mm disks and placed in the center of each Petri dish. The experimental design had five treatments, T1, T2, T3, T4, and T5, with crescent concentrations of WV, respectively, 0 (control), 5, 10, 15, and 20 mL L-1. The variables evaluated were fungal growth, mycelial growth rate index, and percentage of mycelial growth inhibition.
 
Results and Discussion: A gradual decrease in the mycelial growth, in the mycelial growth rate index, and an increase in the percentage of mycelial growth inhibition were determined for all assessed fungi in the concentration of 20 mL L-1 of WV. Hence, the conclusion was that eucalyptus WV presented fungi-toxic properties over the assessed fungi and the product can be considered as an alternative for the chemical control of the incidence of these pathogens in crops and forest plantations.
 
Research Implications: The use of natural products with fungi toxic properties is becoming important for the control of pathogens that attack crops and forest plantations due to the harmful effects of the conventional fungicides on living organisms and the environment. The search for efficient alternative products is therefore a goal to be reached in the field of phytopathology.
 
Originality/ Value: The use of natural products with fungitoxic properties has been gaining ground in the control of pathogens affecting agricultural and forestry crops. This intensifies the search for natural products that are efficient in the biocontrol of phytopathologies.
Technological Innovation In Civil Construction
Authors: Costa Michelle Nascimento , Carrara Júlia Martins , Stefano Ercilia de , Rodriguez Tatiana Tavares , Freitag Alberto Eduardo Besser , Barreto João Carlos , Pereira José Cristiano
Published: November 2024

Objective: The objective of this study is to present the importance of technological innovations in the construction sector, detailing some tools and devices that can be used, aiming to show how the adoption of new technologies can reduce costs and promote sustainable practices.
 
Theoretical Framework: The study highlights research and authors focused on technological innovation and sustainability in construction, providing a solid foundation for understanding the opportunities and challenges faced by the sector in adopting modern technologies.
 
Method: The methodology adopted for this research comprises a bibliographic study, based on academic and electronic sources addressing technological innovations in construction.
 
Results and Discussion: The results highlight the urgent need for modernization in Brazilian construction, showing the positive impact of technology adoption on cost reduction and sustainability. The discussion addresses resistance to innovation and the benefits for companies that adopt technologies, as well as limitations within the sector.
 
Research Implications: The practical and theoretical implications include applications for companies and public policies that encourage innovation and sustainability, promoting greater competitiveness in the sector.
 
Originality/Value: This study demonstrates the relevance of technological innovations in construction, a sector essential to the economy but resistant to change. It highlights how emerging technologies can improve efficiency and sustainability in Brazil.
From Software Management to Software Ecosystem Governance: A Bibliographic Review on Software Governance Practices Within Organizations and Their Evolution
Authors: Andrade Alexandre dos Santos , Feitosa Marcelo Duduchi , Azevedo Marilia Macorin de
Published: November 2024

Objective: The objective of this study is to map the publications that deal with IT Governance and the main aspects of Software development, acquisition and maintenance, identifying when the concepts related to software governance emerged and the main search sources for publications on the subject, highlighting the central issues of each of the emerging contexts.
 
Theoretical Framework: A theoretical framework was used on the organizational structure of IT governance areas, focused on directing, analyzing and monitoring software development, differentiating the typical management activities designed by Juiz and Colomo-Palacios (2020).
 
Method: The methodology adopted for this research comprises a qualitative-quantitative approach, using bibliometrics, bibliographic analysis and the application of a fractional authorship algorithm to identify the main authors to publish on the topic. Data collection was done using a set of search databases such as the Web of Science database and the Scopus database.
 
Results and Discussion: The results obtained revealed the main authors identified in each of the databases searched, as well as the central themes of the searched themes, indicating the first appearance of each term and its main article. It is also possible to analyze the academic production related to each of these themes.
 
Research Implications: The practical and theoretical implications of this research indicate fields of research that have become popular, bringing perspectives for future work, as well as fields that are being poorly explored in software development governance and management.
 
Originality/Value: This study contributes to the area of ​​Information Technology management as the main themes studied in governance and management of software development formalize essential concepts for these fields of research and promote process improvement.
Hybridization of Cockcroft-Walton and Dickson Voltage Multipliers for Maximum Output Through Effective Frequency Dedication in Harvesting Radio Frequency Energy
Authors: Udechukwu Felix Chimezie , Ahaneku Mamilus , Chijindu Vincent Chukwudi , Oyeka Dumtoochukwu , Maryrose Chineke-Ogbuka Ifeanyi , Amoke Douglas Amobi
Published: November 2024

Objective: This study investigates solutions to the challenges of limited RF energy harvesting by designing a hybridized voltage multiplier system aimed at optimizing output across a wide frequency range.
Theoretical Framework: The research centers on the principles and comparative efficiencies of the Cockcroft-Walton and Dickson voltage multipliers, known for their applications in RF energy harvesting. These multipliers’ performance was analyzed theoretically to guide a hybrid design that could adaptively respond to input frequency variations.
Method: Voltage multipliers were designed and simulated in Multisim, with further analysis in MATLAB. Both the Cockcroft-Walton and Dickson voltage multipliers were subjected to a constant input of 1V across frequencies from 50 Hz to 5 GHz to assess their respective efficiencies. Subsequently, a hybrid voltage multiplier system was developed, combining an 8-stage Cockcroft-Walton and an 8-stage Dickson multiplier. A fast Fourier transform (FFT) frequency-selective algorithm, implemented in MATLAB, dynamically directed input voltages to the optimal multiplier based on frequency.
Results and Discussion: Results showed that the Dickson multiplier excelled in the lower frequency range (50 Hz to 1 MHz), achieving a maximum output of 14.763V at 5 kHz and 10 kHz. In contrast, the Cockcroft-Walton multiplier was more effective in the higher frequency range (1 MHz to 5 GHz), reaching a peak output of 6.671V at 5 GHz. The hybrid system demonstrated efficient, frequency-dependent voltage multiplication and aligned well with anticipated performance metrics, suggesting an improvement in RF energy harvesting across the tested frequency range.
Research Implications: This work contributes to the field of RF energy harvesting by introducing a frequency-adaptive system that enhances voltage output through targeted frequency routing. The results underscore the potential for hybrid designs to overcome limitations associated with individual voltage multipliers, presenting a versatile approach to harvesting RF energy effectively across broad frequency spectra.
Originality/Value: By implementing a hybrid approach with a frequency-selective algorithm, this study offers an innovative solution for frequency-dependent RF energy harvesting. The findings provide a foundation for future research into adaptable energy harvesting systems that optimize voltage output across diverse frequencies, with practical implications for RF-powered devices and wireless energy transfer applications.
Evaluation of lead levels in children with chronic constipation
Authors: Güney Abdurrahman Zarif , Doğan Güzide , Toprak Ali
Published: November 2024

Objectives. This study aimed to assess blood and hair lead levels (BLL and HLL) in children with chronic constipation and compare them to healthy children; and investigated lead exposure’s role in the etiology of constipation. It also explored the correlation between BLL and HLL.
Study Design. The study included 84 constipated children aged 3-18 years as the case group and an equal number of constipation-free children as controls. Organic diseases were ruled out through history-taking, physical exams and laboratory tests. Blood and hair samples were collected and analyzed for lead levels using standardized methods.
Results. The constipated children group had significantly higher BLL (3.66 µg/dL) compared to the control group (1.61 µg/dL) with no significant HLL difference. Additionally, 48.8% of constipated children exceeded the reference value of 3.5 μg/dL, in contrast to 4.8% of the control group. BLL was unaffected by gender and age, while HLL were higher in girls and low ages. No significant correlation existed between BLL and HLL. The age of the housing showed a positive correlation with higher BLL and HLL. Lead exposure sources like drinking water, home renovation history, parental smoking, or nearby industrial facilities showed no significant relationships with lead levels.
Conclusions. Understanding the constipation-lead exposure link is crucial for prevention and intervention. HLL may vary with gender and age due to external lead particles, which is why BLL continues to be a more reliable measure. Healthcare providers should remember to investigate lead exposure risk factors in constipation patients and test BLL when necessary.
Changes in skin barrier integrity by electrical impedance spectroscopy during dupilumab treatment on a child with severe atopic dermatitis
Authors: Yaycı Elif , Ezelsoy Işıl , Gündoğdu Beliz Su , Büyüktiryaki Betül , Saçkesen Cansın
Published: November 2024

Background. Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal skin barrier dysfunction and altered immune response. Electrical impedance spectroscopy (EIS) has been used as a novel tool to detect skin barrier changes in AD. EIS is a non-invasive measure of the electrical impedance of tissue and is sensitive to cellular structure and extracellular environment.
Case Presentation. An 8-year-old girl presented with severe AD, starting at 3 years of age. She also had allergic rhinitis, food allergies, and sensitization to mites, eggs, and nuts. Unresponsive to other treatments, she was administered 300 mg of dupilumab, a monoclonal antibody inhibiting IL-4 and IL-13 activity. Patient’s response to the treatment and skin barrier integrity was followed for 6 months: First at the baseline (before dupilumab) and then again at the 1st, 2nd, 3rd, and 5.5th month after dupilumab with SCORing Atopic Dermatitis (SCORAD), as well as measurements of moisture by MoistureMeterSC (Delfin®) and EIS by Nevisense® (SciBase) on the forearm and antecubital fossa of the same arm. At the end of 6 months, her SCORAD improved from 96 to 37. The moisture measurements were variable. The EIS by Z1 score in the forearm increased from 72 to 141 and EIS by MIX scores increased from 2.7 to 6.2. The correlation between SCORAD and forearm EIS by Z1 and MIX scores were significant: r=-0.913, (p=0.03) and r=-0.881, (p=0.049). The correlation between forearm MIX scores with sleeplessness and itching was significant: r=-0.956, (p=0.011), r=-0.942, (p=0.017).
Conclusion. As higher EIS scores reflect stronger barrier integrity, the increase in Z1 and MIX obtained from Nevisense® implies an improvement in the skin barrier integrity during dupilumab treatment. This report highlights the potential use of EIS in atopic dermatitis patients to evaluate treatment efficacy. We urge rapid and non-invasive use of EIS in pediatrics to be further investigated in clinical settings.
Comprehensive analysis of genotypic and phenotypic characteristics of biotinidase deficiency patients in the eastern region of Türkiye
Authors: Çıkı Kısmet , Alavanda Ceren , Ceylan Emine İpek , Tanyalçın Tijen , Kılavuz Sebile
Published: November 2024

Background. Biotin is a water-soluble vitamin that plays a key role in carboxylation. The formation of free biotin is impaired in biotinidase deficiency (BD), resulting in impaired biotin-dependent carboxylase functions. Based on the percentage of residual serum enzyme activity, BD is classified as partial and profound.
Methods. Retrospective data including gender, age, parental consanguinity, family history, biotinidase activity analyses, type of deficiency (partial-profound), physical examination, treatment, and genotypes were evaluated in patients diagnosed with biotinidase deficiency in a single center in the eastern region of Türkiye. Patients whose biotinidase enzyme activity was below 30% with biallelic variants in the BTD gene were diagnosed as BD.
Results. A total of 302 patients were included in the study. Parental consanguinity was present in 135 (44.7%) of them. Two hundred eighty-six (94.7%) were diagnosed by neonatal screening, 14 (4.6%) by family screening and two (0.06%) by clinical symptoms. Ninety-two (30.5%) of the patients were followed-up with profound deficiency and 210 (69.5%) with partial deficiency. A total of 306 variants were detected. Twenty different variants (3 novel - 3 rare) and 31 different genotypes were detected. The 3 most frequently detected variants were c.410G>A (p.Arg137His; 47.3%), c.1270G>C (p.Asp424His; 29.7%), and c.38_44delGCGGCTGinsTCC (p.Cys13Phefs*36; 15.3%). The 3 most frequently identified genotypes were c.410G>A (p.Arg137His) / c.1270G>C (p.Asp424His) compound heterozygous (32.4%), c.410G>A (p.Arg137His) homozygous (24.8%), and c.38_44delGCGGCTGinsTCC (p.Cys13Phefs*36) / c.1270G>C (p.Asp424His) compound heterozygous (12.2%). Patients with c.410G>A (p.Arg137His) homozygous variant, c.38_44delGCGGCTGinsTCC (p.Cys13Phefs*36) homozygous variant and c.38_44delGCGGCTGinsTCC (p.Cys13Phefs*36) / c.410G>A (p.Arg137His) compound heterozygous variant were statistically significantly associated with profound deficiency. Compound heterozygosity of c.410G>A (p.Arg137His) / c.1270G>C (p.Asp424His) variants were significantly associated with partial deficiency.
Conclusions. The association between the BTD genotype and biochemical phenotype is not always consistent. Our study provides valuable data by adding variants with genotype-phenotype correlations to the literature and three novel variants, which can provide significant guidance in clinical follow-up.
Reseña de: Jasso Vargas, R. (2023). Vidas Truncadas: muertes de personas migrantes centroamericanas en tránsito por México. México: Centro de Investigaciones Multidisciplinarias sobre Chiapas y la Frontera Sur, Universidad Nacional Autónoma de México, 180
Authors: Lisbona Guillén Miguel
Published: November 2024

Abstract: Review of: Jasso Vargas, Rosalba, Vidas Truncadas: muertes de personas migrantes centroamericanas en tránsito por México, México, Centro de Investigaciones Multidisciplinarias sobre Chiapas y la Frontera Sur, Universidad Nacional Autónoma de México, 2023, 180 pp. ISBN: 978-607-30-7628-9.
Types of conjunction usage
Authors: Yang Tingting
Published: November 2024

This article is devoted to subordinating conjunctions, in particular conditional and causal conjunctions, which have two semantic valences – the valence of condition or cause and the valence of effect. These conjunctions can be used in two types of sentences: in sentences where both valences of conjunctions are expressed explicitly, and in sentences where one of the valences is not expressed. At the same time, the content of the valence can be information related to different levels of the semantics of the sentence – to the propositional and to the pragmatic levels. The propositional level is formed by information about the situation called by the sentence, and the pragmatic level consists of meanings reflecting various aspects of the speech situation. The pragmatic level, in particular, includes such semantic components as illocutionary, epistemic and metatextual. Thus, the subject of the study is the types of conjunctions usage, distinguished depending on how their valences are expressed and what their content is. When describing the constructions, we used the method that is applied to the analysis of linguistic units expressing various subjective meanings. This method consists in explicating the features of the speech situation related to the use of a given language unit (the speaker's evaluation of the denoted situation, information about it or his/her own utterance) and taking them into account when characterizing its meaning. The novelty of this study lies in the systematic approach to the analysis of subordinating conjunctions, which is based on the identification and classification of their usage depending on the level of semantic relations. Thus, in sentences with subordinating conjunctions (especially conditional and causal conjunctions) the valences of conjunctions differ in the way of expression and the level of semantics. This allows us to distinguish four types of conjunctions usage: propositional, illocutionary, epistemic and metatextual.
Megaformer as a Rehabilitation Modality for Hamstring Strain Injury in Division I American Football: A Case Study
Authors: Vassilian Anthony , Noceti-DeWit Lisa , Schroeder E. Todd
Published: November 2024

BACKGROUND: With athletes striving for peak performance, noncontact muscle strain injuries are increasingly common. Hamstring strain injuries (HSIs) make up the largest portion of noncontact injuries and provide further difficulty because of the high reinjury rate. This case study explores the Megaformer as a modality to treat HSIs with the potential to reduce the return-to-play timetable and recurrence rate.

CASE PRESENTATION: A 23-year-old male American football player with a history of hamstring injuries presented with pain in the right proximal hamstring and deficits in strength and mobility testing as a result of sustained hyperflexion of the right hip with full knee extension. Magnetic resonance imaging confirmed a recurrent proximal hamstring strain.

OUTCOME AND FOLLOW-UP: Subsequent strength and range-of-motion testing revealed no impactful tenderness or pain during active participation or palpation after 9 days, and complete alleviation of symptoms at 6 weeks. No reinjury occurred during the remaining football season.

DISCUSSION: This case study highlights possible advantageous features of the Megaformer as a recovery modality for HSIs. The Megaformer aims to improve flexibility, strengthen primary and secondary muscles, and enhance neuromuscular coordination to attempt to decrease the return-to-play timetable and reduce injury recurrence. JOSPT Cases 2025;5(1):25-29. Epub 11 November 2024. doi:10.2519/josptcases.2024.0056