bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of Phloretin-loaded Nanospanlastics for Targeting of FAS/SREBP1c/AMPK/ OB-Rb Signaling Pathway in HFD-induced Obesity
Authors: Alamir Mohamed , Hussein Mohamed A. , Aboud Heba M. , Khedr Mohamed H. , Zanaty Mohamed I.
Published: May 2024

Objectives:

Obese patients are at increased risk for CVD, which is the main cause of
premature death and has been a major cause of disability and ill health in recent years. PTN, a
natural dihydrochalcone flavonoid, has a variety of pharmacological characteristics. This article
aimed to prepare PTN-NSLs to evaluate their anti-obesity activity.

Methods:

Morphology, Particle size, zeta potential, UV-vis, entrapment efficiency, FT-IR spectra,
and an in vitro release study of PTN-NSLs were described. PTN-NSLs were also tested for
their anti-obesity properties in obese rats. The LD50 of PTN-NSLs was calculated, as was the
1/20 LD50 prepared for the treatment of obese rats. Also, the level of glycemic, oxidative stress
and inflammatory biomarkers were estimated in the obese rat’s model.

Results:

The synthesized PTN-NSLs were uniform, spherically shaped, and well dispersed with
no aggregation noted, with a size range of 114.06 ± 8.35 nm. The measured zeta potential value
of PTN-NSLs was -32.50.8 mv. Also, the UV spectra of PTN and PTN-NSLs have strong absorption
at 225 and 285 nm. Also, the LD50 of PTN-NSLs was found to be 2750 mg/kg.b.w.
Moreover, administrating obese rats with PTN-NSLs resulted in improved glycemic features as
well as GSH, SOD, GPx, GR, IL10, TBARs, and IL-6 levels, as well as attenuated FAS,
SREBP1c, AMPK, ACO, CPT1, and OB-Rb gene expression.

Conclusions:

Administration of PTN-NSLs significantly attenuated the levels of glycemic, oxidative
stress, and inflammatory biomarkers. The biochemical and PCR findings are aided by
histological investigations. Also, the present findings imply that PTN-NSLs might be a promising
pharmacological tool for the treatment of obesity-related diseases.
Assessment of Knowledge and Concern of People Living with HIV
Regarding Human Mpox and Vaccination
Authors: Borcak Deniz , Özdemir Yusuf Emre , Yesilbag Zuhal , Ensaroğlu Esra , Akkaya Samiha , Yaşar Kadriye Kart
Published: May 2024

Introduction:

Mpox virus is an orthopoxvirus that causes the zoonotic infectious disease
known as mpox. The disease can also spread from humans to humans. It can be transmitted
through contact with bodily fluids, lesions on the skin, or internal mucosal surfaces.

Method:

The number of mpox cases increased during the COVID-19 pandemic. Early diagnosis
and prompt management of mpox are critical in people living with HIV (PLHIV). In this study, a
cross-sectional survey was conducted among PLHIV followed at the outpatient clinic between 20
April–20 August 2023. A questionnaire was used to assess the knowledge and anxiety levels of patients
as well as their opinions about vaccination against mpox. The severity of symptoms in the
past two weeks was assessed using the Generalised Anxiety Disorder 7-item scale. A total of 203
PLHIV were interviewed for this survey study.

Result:

The mean age was 39.37±11.93. The majority of them were male (86.7%), and 41.4%
were men who have sex with men (MSM). Only 21 of the surveyed participants (10.4%) had a
“good knowledge” score about mpox. The mean knowledge score on human Mpox was 2.05
(min:0-max:8), and 107 (52.7%) had a score of 0.

Conclusion:

The future study should focus on continuous education, promoting awareness
through programs and establishing measures to successfully overcome identified variables that
contribute to mpox pandemic understanding and attitudes. Applying the lessons learned from the
COVID-19 pandemic will help the management of mpox virus.
Analytical and Bioanalytical Methods for the Determination of Dipeptidyl Peptidase-4 Inhibitors in Various Matrices: A Comprehensive Review
Authors: Hadawale Sakshi , Sharma Sanjay
Published: May 2024

Background:

DPP-4 inhibitors, or gliptins, are new oral antidiabetic drugs for type 2 diabetes.
They help to regulate insulin and glucagon. These drugs have the advantage of a lower risk of hypoglycemia
compared to some other diabetes medications and are typically prescribed when metformin
and sulphonylureas have become less effective.

Objective:

This review analyses a range of analytical and bioanalytical methods for DPP-4 inhibitors,
that use spectroscopic techniques, chromatographic, and hyphenated techniques for analysis. So far, no
review comprising all DPP-4 inhibitors has been presented. The primary objective of this review is to
present the analysts with various analytical and bioanalytical methods for the quantification and estimation
of DPP-4 inhibitors in different matrices.

Methods:

To improve understanding, a review was carried out by creating a database of pre-existing
research from digital sources such as ScienceDirect, and PubMed. The methodology is shown in the
flowchart of the literature selection process.

Conclusion:

The comprehensive assessment of methods for analysing DPP-4 inhibitors can be a valuable
resource for researchers and healthcare practitioners. Hitherto, no review encompassing all DPP-4
inhibitors has been presented. Therefore, gaps in the data available on a particular subject, need to be
required to collect data on a particular construct. The review suggests that chromatographic techniques
were majorly used for analysis wherein solvents like acetonitrile, methanol, and buffer solutions were
used as mobile phases that can deteriorate HPLC columns and equipment. So, scientists could investigate
new methods for the assessment of DPP-4 inhibitors using more eco-friendly solvents.
A Systematic Review of Herbal Interventions for the Management of
Cardiovascular Diseases
Authors: Wal Ankita , Verma Neha , Balakrishnan Senthil Kumar , Gahlot Vinod , Dwivedi Sumeet , Sahu Pankaj Kumar , Tabish Mohammad , Wal Pranay
Published: May 2024

Background:

Cardiovascular diseases represent a significant global health burden,
necessitating diverse approaches for effective management. Herbal interventions have gained
attention as potential adjuncts or alternatives to conventional therapies due to their perceived
safety and therapeutic potential. This structured abstract provides a comprehensive review of
herbal interventions for the management of CVDs, summarising key findings, mechanisms of
action, and clinical implications.

Objective:

This systematic review aims to evaluate the impact of various herbal interventions
employed for managing cardiovascular diseases.

Method:

We conducted an extensive literature search across electronic databases, including
PubMed, Scopus, and Web of Science, from inception to 2022. Studies were included if they
investigated the use of herbal remedies for preventing or treating CVDs. Data extraction and
synthesis focused on botanical sources, active compounds, mechanisms of action, and clinical
outcomes.

Result:

Numerous herbal interventions have demonstrated promising cardiovascular benefits.
A number of medicinal herbs well identified to treat CVD are Moringaoleifera, Ginseng,
Ginkgo biloba, Celosia argentea, Gongronematrifolium, Gynostemmapentaphyllum, Bombaxceiba,
Gentianalutea, Allium sativum, Crataegusspp, Curcuma longa, Camellia sinensis, and
Zingiberofficinale. Mechanistic insights reveal that herbal interventions often target multiple
pathways involved in CVD pathogenesis. These mechanisms encompass anti-inflammatory,
antioxidant, anti-thrombotic, anti-hypertensive, and lipid-lowering effects. Additionally, some
herbs enhance endothelial function, promote nitric oxide production, and exert vasodilatory
effects, contributing to improved cardiovascular health. Clinical studies have provided evidence
of the efficacy of certain herbal interventions in reducing CVD risk factors and improving
patient outcomes. However, more rigorous, large-scale clinical trials are needed to establish
their long-term safety and effectiveness. It is crucial to consider potential herb-drug interactions
and standardise dosages for reliable therapeutic outcomes.

Conclusion:

This comprehensive review highlights the potential of herbal interventions as
valuable adjuncts or alternatives for managing cardiovascular diseases. Herbal remedies offer
diverse mechanisms of action, targeting key CVD risk factors and pathways. While promising,
their clinical utility warrants further investigation through well-designed trials to establish
their safety and efficacy, paving the way for integrated approaches to cardiovascular disease
management. Healthcare providers and patients should engage in informed discussions about
the use of herbal interventions alongside conventional therapies in the context of CVD prevention
and treatment.
Stone Mastic Asphalt Modified With Nano Titanium Dioxide And Potential Exposure To Blast Load: A Review
Authors: Zali Nur Syafiqah Shamimi Mohd , Masri Khairil Azman , Abu Seman Mazlan
Published: May 2024

This article states the modification of stone mastic asphalt with nano titanium dioxide and the advantage it has over conventional asphalt. The transport infrastructures must meet the needs of transport as well as other requirements like resilience and multi-hazard resistance in order to satisfy society's desire for sustainable development. Hence, blast load is introduced in this paper as one of the potential hazards that may be exposed to pavements. The use of SMA with nano titanium is believed to impact the pavement's behaviours significantly and can potentially resist higher blast loads and reduce failure in samples. As real field blast tests are limited, a numerical analysis is done to assess the modified pavement's enhancement. The article concludes by recommending using SMA modified with nano titanium as a promising solution to withstand blast loads in pavements.
Synergic Usage of Pistia stratiotes sp., Eichhornia crassipes sp., Typha angustifolia sp., and Lepironia Articulata sp. Plants for Sewage Treatment via Phytoremediation Technology
Authors: Hairolnizam Nurul Farah Anisa , Sulaiman Suryati , Razak Abdul Syukor Abd , Mokhtar Nadzirah Mohd , Mokhtar Nadiah , Aziz Azrina Abd , Chin Khor Bee
Published: May 2024

Introduction

Domestic wastewater management is challenging on a worldwide level. The discharge of a large amount of nitrogen and phosphate from sewage accelerates pollution can lead to reduced oxygen levels, excessive algal blooms, the expansion of aquatic weed plants, and the destruction of the aquatic environment. As a result, the right wastewater treatment is required prior to discharge into natural water bodies in order to prevent contamination and fulfill the wastewater acceptable limits established by the government and environmental protection agencies. For Previous studies, most of the research is carried out in a controlled environment within a small time frame. Phytoremediation offers a viable alternative by harnessing the natural capabilities of plants to enhance the degradation and removal of pollutants in sewage.

Aims

The objective of this study is to evaluate the phytoremediation performance using Pistia stratiotes sp., Eichhornia Crassipes sp., Typha angustifolia sp., and Lepironia Articulata sp. in treating real domestic wastewater.

Methods

The phytoremediation system conducted continuous treatment at the Sewage Treatment Plant (STP) effluent at Selangor, Malaysia. To the best of our knowledge there are no studies conducted on the phytoremediation plant in real STP using 4 types of aquatic plants in a row to achieve a high percentage removal of pollutants. This research observation was conducted by collecting data every 2 weeks for 4 consecutive months including the maintenance terms. In terms of pollutant removal, the phytoremediation system showed the highest removal efficiency in all tested parameters.

Results

The highest removal efficiency recorded for biochemical oxygen demand (BOD), chemical oxygen demand (COD), total suspended solids (TSS) and ammoniacal nitrogen (AN) were 68.38%, 70.95%, 59.21% and 25.00%, respectively.

Conclusion

Following the guidelines of the Environmental Quality (Sewage Effluent) Regulation 2009 Malaysia, synergic usage of the aquatic plant had successfully achieved Standard A for sewage discharge after applying the phytoremediation technology while it has been proven that the environmentally friendly technologies can reduce the risk of water pollution by using the selected plant and may solve the water shortage with a cost-effective and efficient solution to wastewater treatment.
Attitude of “AAB College” Nursing Students Towards Scientific Research
Authors: Haxhija Edona , Shabani Zamira , Zylfo Armela , Shkoza Donika , Ramaj Arlinda
Published: May 2024

Aims

AAB College is a non-public institution that dates back to 2017, and during its internal evaluation, the involvement of nursing students in scientific research has appeared problematic, so the purpose of this study is to first identify the attitude of nursing students towards scientific research only in this college later in the near future we will compare with a public institution.

Background

Since higher education institutions are subject to accreditation, and one of the key points is scientific research and the involvement of students in this process, we thought of investigating this issue. It is necessary for nursing students to have a culture of scientific research because this affects the increase of their performance in school, at work and also in the improvement of the quality of service to patients. Nursing students should be initiated into the research culture and adopt positive attitudes toward scientific research during their undergraduate education to improve the nursing profession, contribute to the professionalization of this profession, and maintain quality of care, nurse autonomy, and power. This research should transmit, promote, and protect knowledge in the improvement of teaching, scientific research, and community services.

Objective

Cross-sectional descriptive statistics were used to summarize the importance of research to nursing students, the time students spend on research, student attitudes toward science, how collaborative research professors were with students, and the motivation provided to students by faculty or professors.

Methodology

Data collection was carried out during January - June 2022. The sample was randomly selected. In this study, 300 students of “AAB College” were included. Students were given a questionnaire administered by us. To perform the statistical analysis, we used the SPSS program 19 version and Microsoft Office 2010.

Results

The minimum age of the students who were interviewed is 18 years. 64% of these students are female (n=192), and 36% are male (n=108).

Conclusions

The largest percentage of students state that scientific research is “Very important” for them. The lectures related to research in nursing have “a lot of influence” on their formation. Students spend “Enough” time or energy on scientific research. The faculty/college where they study does not offer them support for studies or scientific activities. The majority of students have not participated in any scientific activity, but students who have been active or passive participants in scientific activities are referred to being provided with training certificates. Students feel “enough” motivated to carry out scientific work in the nursing field.
Breath-holding Test in the Prognosis of Postoperative Pain in Laparoscopic Gynecology: Observational Cohort Study
Authors: Dmitriev Alexey , Trembach Nikita
Published: May 2024

Background

The problem of perioperative pain relief has not lost its relevance over the years. Studies have shown that patients report moderate to severe pain after surgery, even after laparoscopy. In recent years, specialists have focused on the role of baroreflex sensitivity in the functional state of the nociceptive and antinociceptive systems. Studies have shown that a test with maximum breath-holding during inspiration allows for a non-invasive and accurate assessment of the functional state of the cardiorespiratory system, making it possible to identify a cohort of patients with reduced baroreflex sensitivity

Objective

The aim of the study was to assess the relationship between the breath-holding test and postoperative pain and to develop a model for predicting pain after laparoscopic gynecological surgery.

Methods

Data from 489 patients undergoing gynecological laparoscopy at the Clinic of the Kuban State Medical University from August 2019 to September 2023 were analyzed.

Results

Severe postoperative pain was reported in 146 patients (29.9%). The duration of breath-holding was statistically significantly correlated with NRS upon admission to the PACU at all time points of the study (from -0,15 to -0,21). Logistic regression showed that the Generalized Anxiety Disorder scale score, Pain Catastrophizing Scale score, duration of surgery, Breath-holding duration, and endometriosis surgery influenced the risk of severe postoperative pain (NRS 7-10) (AUROC 0,809).

Conclusion

The breath-holding test, along with other factors, may be useful in assessing the risk of severe postoperative pain after laparoscopic gynecology.
The Mass Gap in QCD and a Restriction on Gluon Masses
Authors: Larin Sergey. A.
Published: May 2024

:

In this study, we prove that it is necessary to introduce the non-zero gluon masses into
the fundamental Lagrangian of Quantum Chromodynamics in order to describe the mass gap in
the reaction of electron-positron annihilation into hadrons. Further, in this work, a new restriction
on the gluon masses is imposed, and the renormalized theory with non-zero Lagrangian gluon
masses is presented
Client-Centered, Person-Centered, and Resilience-Based Approaches to Trauma-Informed Care
Authors: Stephany Kathleen
Published: May 2024

Chapter three explores client-centered, person-centered, and resiliencefocussed approaches to trauma-informed care, and although they differ somewhat, all
three are strength-based and share the common goal of helping people who have
experienced adversity. Client-centered care places the person and their capacity for
growth and change at the heart of all that occurs. This approach prioritizes respect for
the self-worth of every human being and promotes the practice of unconditional
positive regard. The quality of the therapeutic relationship between the nurse and
client/patient is important, as is the nurse’s ability to apply professional knowledge and
competence to the care they provide. A unique aspect of person-centered care is that it
provides services to people with acute and chronic health issues that are holistic, and
recovery-orientated. Collaboration and effective communication skills are essential
features of this approach. Positive ways to offer person-centered care to people from
these populations are reviewed, the elderly, those with a disability, people with
dementia, palliative care patients, and persons suffering from mental illness and
substance use. Specific components of recovery-oriented care that are included in the
discussion are a person’s capacity for change and courage, their responsibility for their
growth, and the importance of finding purpose in their lives. Resilience is identified as
the is the ability to carry on and bounce back to original functioning after experiencing
a trauma. We are made aware that a resilient person becomes stronger despite adversity
because they utilize positive emotions, develop a sturdy mindset, a renewed
commitment to life, and welcome challenges. The remainder of the discussion focuses
on how to safely conduct screening for trauma for everyone including survivors of
interpersonal violence (IPV). Two Narrative Case Studies are presented. The first one
demonstrates that when a client/patient crosses a professional boundary, a problem is
created for the nurse. The second Case Study explores how a survivor of interpersonal
violence (IPV) may require advocacy to help them stay safe. The following four
learning activities are recommended, how to practice unconditional positive regard;
exploring helpful strategies to utilize when conducting trauma screening; dispelling
myths associated with IPV; and how to implement survivor-centered approaches when
caring for someone who has experienced IPV. At the end of the Chapter, a self-care
strategy is recommended that challenges nurses to set aside time to focus more on
being present.
The Adoption of Big Data in the Education Sector
Authors: Khalid Abdul-Mumin , Owusu-Boateng Obeng
Published: May 2024

Big Data enables higher educational institutions the ability to efficiently use
information technology resources to enhance the effectiveness of education and
performance. This chapter explores the meaning of big data applicable to educational
institutions, identifies the factors that affect the adoption of big data approach in higher
education institutions, especially for strategic management purposes and aims to
examine the challenges of adopting big data in higher education institutions. The
literature sources are from journals on scientific studies and articles, and research
papers. The benefits of BD in the education sector include academic productivity,
teaching efficiency, organization of processes, freedom of tech stack/tech stack
independence, reduction in student dropout, managing the business's finances and
operations, maintaining open and honest communication, multiplication of data,
accelerating the instructional process and personalization. The driving factors are the
TEO framework (organizational, technological and environmental), etc
An Estudio etnobotánico de los usos de plantas medicinales del grupo étnico Nasa en los Andes colombianos
Authors: Paz Perafán Gisela Mabel , Montenegro Paz Gerardo
Published: May 2024

Antecedentes y Objetivos: Las principales fuentes terapéuticas de la medicina tradicional de la etnia Nasa en los Andes colombianos provienen de expertos, parteras y médicos tradicionales (Thë’ Wala) ubicados en la cordillera central de los Andes colombianos, la cual ocupa una superficie de 25,400 hectáreas. Nuestra investigación etnobotánica parte de la hipótesis que el conocimiento tradicional Nasa revela información crucial sobre plantas nativas con potencial terapéutico.Métodos: Todas las especies colectadas fueron determinadas en el herbario de la Universidad del Cauca (CAUP). Las dolencias se clasificaron en 15 categorías de enfermedades. Se utilizó el factor de consenso del informante (ICF) para evaluar el grado y la relevancia cultural del uso de los taxones para las diferentes categorías de enfermedades, y el índice de valor de uso (UV) para establecer un consenso sobre la efectividad de las especies utilizadas para curar las diferentes dolencias.Resultados: Nuestro estudio reporta 106 plantas medicinales, pertenecientes a 45 familias. Asteraceae constituye la familia más predominante, seguida de Lamiaceae. Las dolencias que afectan al sistema digestivo fue el grupo más afectado, utilizándose 26 especies de plantas (24.5%). Los valores del ICF oscilaron entre 0.96 y 1, registrándose los valores más altos para el cáncer y el envenenamiento (1 cada uno). Algunas plantas se cultivan en la huerta o “Tul” y otras se recolectan en regiones montañosas o en zonas de páramo, confirmando la fragilidad de la farmacopea en estas regiones.Conclusiones: Los hallazgos de este estudio subrayan la importancia de las plantas medicinales y su papel integral en las actividades humanas diarias y el manejo de enfermedades de la etnia Nasa. Ciertas especies nativas con alto valor medicinal, pero con poblaciones silvestres en marcada disminución, deberían estudiarse con fines de evaluación y conservación de recursos. Se necesitan futuras investigaciones sobre la composición química y la bioactividad de las plantas medicinales.
ANALYSIS OF VIBRATION CHARACTERISTICS ON WA-350 WHEEL LOADER HEAVY EQUIPMENT MACHINE BASED ON CAPACITY COMPARISON WITH 2000 RPM ROTATION IN HORIZONTAL, VERTICAL AND LONGITUDINAL AREAS
Authors: Sihombing Suriady , Nababan Wilson Sabastian , Tampubolon Miduk , Panjaitan Fernando
Published: May 2024

Wheel loader is a tool that facilitates the work of moving materials from one place to another using hydraulic energy. Wheel loader machine testing is carried out by looking for vibration data arising in the engine block. There are several stages that must be done, the first step is preparation of a Handheld Vibrometer as a vibration detection device. Next, examine the vibration level read on the Handheld Vibrometer with ideal, medium, and maximum rotation. Based on the ISO 2372 standard, vibration response results are obtained where the power capacity of a diesel motor is 350 kW where the highest speed is 62.7 mm / s with a horizontal direction at 90 seconds, categorized in Zone D in red, vibration from the engine is within dangerous limits and can be damaged at any time.
Elevating Healthcare Resilience: Role of drones in mitigating supply chain challenges in Malaysia
Authors: Wahab Siti Norida , Othman Norashida , Sahak Muhammad Yazid , Subramaniam Nikram
Published: May 2024

This paper explores the usage of drones in the Malaysian healthcare supply chain (HSC) and proposes strategies by identifying the challenges faced. A detailed literature review found several challenges, such as limited technical capability, strict government regulation, the need for a 5G network, and limited drone capabilities. Hence, some of the identified mitigation strategies are investment in tertiary education, government legislation improvement, expedited 5G network adoption, collaboration with NGOs, and providing drones with multi-functionality. This study contributes to the knowledge relevant to drone technology and the HSC. Future studies should investigate the practicability of drones that can support HSC management.
Barriers to and Facilitators of Key Stakeholders Influencing Successful Digital Implementation of Remote Monitoring Solutions: Mixed Methods Analysis
Authors: Iqbal Fahad Mujtaba , Aggarwal Ravi , Joshi Meera , King Dominic , Martin Guy , Khan Sadia , Wright Mike , Ashrafian Hutan , Darzi Ara
Published: May 2024

Background

Implementation of remote monitoring solutions and digital alerting tools in health care has historically been challenging, despite the impetus provided by the COVID-19 pandemic. To date, a health systems–based approach to systematically describe barriers and facilitators across multiple domains has not been undertaken.

Objective

We aimed to undertake a comprehensive mixed methods analysis of barriers and facilitators for successful implementation of remote monitoring and digital alerting tools in complex health organizations.

Methods

A mixed methods approach using a modified Technology Acceptance Model questionnaire and semistructured interviews mapped to the validated fit among humans, organizations, and technology (HOT-fit) framework was undertaken. Likert frequency responses and deductive thematic analyses were performed.

Results

A total of 11 participants responded to the questionnaire and 18 participants to the interviews. Key barriers and facilitators could be mapped onto 6 dimensions, which incorporated aspects of digitization: system use (human), user satisfaction (human), environment (organization), structure (organization), information and service quality (technology), and system quality (technology).

Conclusions

The recommendations proposed can enhance the potential for future remote sensing solutions to be more successfully integrated in health care practice, resulting in more successful use of “virtual wards.”

Trial Registration

ClinicalTrials.gov NCT05321004; https://www.clinicaltrials.gov/study/NCT05321004
Toward Clinical Generative AI: Conceptual Framework
Authors: Bragazzi Nicola Luigi , Garbarino Sergio
Published: May 2024

Clinical decision-making is a crucial aspect of health care, involving the balanced integration of scientific evidence, clinical judgment, ethical considerations, and patient involvement. This process is dynamic and multifaceted, relying on clinicians’ knowledge, experience, and intuitive understanding to achieve optimal patient outcomes through informed, evidence-based choices. The advent of generative artificial intelligence (AI) presents a revolutionary opportunity in clinical decision-making. AI’s advanced data analysis and pattern recognition capabilities can significantly enhance the diagnosis and treatment of diseases, processing vast medical data to identify patterns, tailor treatments, predict disease progression, and aid in proactive patient management. However, the incorporation of AI into clinical decision-making raises concerns regarding the reliability and accuracy of AI-generated insights. To address these concerns, 11 “verification paradigms” are proposed in this paper, with each paradigm being a unique method to verify the evidence-based nature of AI in clinical decision-making. This paper also frames the concept of “clinically explainable, fair, and responsible, clinician-, expert-, and patient-in-the-loop AI.” This model focuses on ensuring AI’s comprehensibility, collaborative nature, and ethical grounding, advocating for AI to serve as an augmentative tool, with its decision-making processes being transparent and understandable to clinicians and patients. The integration of AI should enhance, not replace, the clinician’s judgment and should involve continuous learning and adaptation based on real-world outcomes and ethical and legal compliance. In conclusion, while generative AI holds immense promise in enhancing clinical decision-making, it is essential to ensure that it produces evidence-based, reliable, and impactful knowledge. Using the outlined paradigms and approaches can help the medical and patient communities harness AI’s potential while maintaining high patient care standards.
Epidemiology of stroke in the Left bank area of Kyiv region on the eve of the 38th anniversary of the man-made Chernobyl disaster: implementing international experience into practice (modern view of the problem and own research)
Authors: Trishchynska М.А. , Onopriyenko O.P.
Published: May 2024

The article highlights the global problems of stroke. Most of them are associated with three groups of risk factors for stroke: well-known pathogenetic, psychogenic, and ecological factors of environmental pollution. The authors draw attention to this on the eve of 38th anniversary of the man-made Chernobyl disaster (April 26, 1986) comparing data on the stroke in Japan after the Fukushima nuclear accident (March 11–12, 2011) due to the earthquake, which led to the reactor core melting at three power units. Issues of improving the provision of specialized medical care to patients with stroke, risk factors for stroke are considered to minimize the consequences, optimize treatment, prevention of risk factors, especially in areas where the population is exposed to incorporated radiation damage through food, water, milk, fish, meat, berries, mushrooms, as well as the issues of improving the specialized stroke care, creation of stroke centers in regions of Ukraine. Studies conducted show that there are many causes of strokes, and they are not yet fully understood. The features of the clinical course of strokes in the Chernobyl liquidators are their development in the middle (40–49 years) and advanced age, long vascular history characterized by vascular dystonia transformation into dyscirculatory (postradiation) encephalopathy during the onset, the predominance of ischemic stroke over hemorrhagic one, lesions mainly of the carotid system, the relative benignity of clinical course, progressive nature of mental disorders, concomitant somatic pathology, the presence of stable pathomorphological substrate from both vascular endothelial dysfunction and cerebral liquor system. The obtained information complements the data on the pathogenesis, clinical picture, diagnosis of cerebral strokes in Chernobyl liquidators and is of practical interest. Raised issues of optimizing the provision of specialized care in stroke units, centers and further rehabilitation, their sufficient supply, both in terms of staffing and equipment, are becoming a cornerstone in overcoming the stroke epidemic. Based on the above, there is still a need to continue substantial research in this area, promptly develop and implement a scientific concept on the prevention, early detection of major modifiable risk factors for stroke together with family medicine doctors, specialist physicians, proper stroke treatment, which will undoubtedly improve quality of life of patients and their relatives.
A Research of Subtitle Translation and International Communication of Chinese Cultural Documentary from the Perspective of Eco-Translatology
Authors: Yao Yingjuan , Li Yun
Published: May 2024

With the acceleration of globalization, the internationalization of film and television works has become a powerful tool to enhance Chinese culture’s international influence. As an important carrier for telling Chinese stories, subtitle translation of Chinese cultural documentaries is very favorable to cultural dissemination. The documentary “China Bouquet” shows the colorful history, folk customs, and humanities of China and is widely disseminated on overseas media platforms. Based on eco-translatology, this paper interprets the subtitle translation skills and international communication effects of it. It finds that translators adapt to translation ecological elements in linguistic, cultural and communicative dimensions to enhance the acceptance of overseas audience. With domestication as the main strategy and foreignization as the auxiliary strategy, translators adopt free translation, conversion, transliteration, omission etc. to demonstrate the charm of Chinese culture and promote effective cultural communication.
Geopolitical Configurations in the Fictional Terrains of Elif Shafak
Authors: Nazeer Adeela Velapurath , R Sumathi
Published: May 2024

Every discourse on geopolitical issues in contemporary world rearticulates how geographical factors such as location, resources, terrain, and climate influence political behaviour, power structures, and foreign policy decisions of states and nations act on the global stage. Any strategy undertaken for geopolitical analysis considers the distribution and exercise of power by examining the capabilities of states in terms of military strength, economic resources, technological advancements, and diplomatic influence. In fact foreign policies are formulated; trade, commerce and international relations are assessed; the significance of territory and borders are shaped; potential disruptions, political instability and shifts in global power dynamics are anticipated; all determined and bridled by the geopolitical flux. Even though literature is primarily entitled to narratives and character build ups, literary texts are often employed by authors to comment on real-world geopolitical issues, power dynamics, and global events. By delineating details such as borders, territories, and geopolitical alliances; by examining the larger politics between individuals, communities, or nations; by weaving complex plots involving espionage agents, political leaders, or diplomats, by highlighting the intricacies of international relations and the pursuit of strategic interests, fictional narratives offer insights into the complexities of human relationships, societal structures, and the forces that shape our world. The current paper is an exhaustive study of the geopolitical configurations and intricate dispositions in the fictional fabric of Elif Shafak, the most widely read Turkish British author whose novels reflect the convoluted tapestry of Turkish society, the intersection of Eastern and Western cultures, and Turkey's unique position bridging Europe and Asia.
The Connected and Forcing Connected Restrained Monophonic Numbers of a Graph
Authors: Santhakumaran A. P. , Titus P. , Ganesamoorthy K.
Published: May 2024

For a connected graph G = (V,E) of order at least two, a connected restrained monophonic set S of G is a restrained monophonic set such that the subgraph G[S] induced by S is connected. The minimum cardinality of a connected restrained monophonic set of G is the connected restrained monophonic number of G and is denoted by mcr(G). We determine bounds for it and find the same for some special classes of graphs. It is shown that, if a, b and p are positive integers such that 3 ≤ a ≤ b ≤ p, p−1 6= a, p−1 6= b, then there exists a connected graph G of order p, mr(G) = a and mcr(G) = b. Also, another parameter forcing connected restrained monophonic number fcrm(G) of a graph G is introduced and several interesting results and realization theorems are proved.
Common Multiples of Paths and Stars with Crowns
Authors: Chandran C. Saritha , T. Reji
Published: May 2024

A graph $G$ is a common multiple of two graphs $H_1$ and $H_2$ if there exists a decomposition of $G$ into edge-disjoint copies of $H_1$ and also a decomposition of $G$ into edge-disjoint copies of $H_2$. If $ G $ is a common multiple of $H_1$ and $H_2$, and $ G $ has $ q $ edges, then we call $ G $ a $ (q, H_1, H_2) $ graph. Our paper deals with the following question: Given two graphs $ H_1 $ and $ H_2$, for which values of $ q $ does there exist a $ (q, H_1, H_2) $ graph? when $H_1$ is either a path or a star with $3$ or $4$ edges and $H_2$ is a crown.
A semilinear non-homogeneous problem related to Korteweg-de Vries Equation
Authors: Benia Yassine , Sadallah Boubaker-Khaled
Published: May 2024

In this paper, we consider a non-homogeneous generalized Korteweg-de Vries problem with some hypotheses on the right-hand side, and we give a new regularity result of the solution in an anisotropic Sobolev space. Then we apply the obtained result to a non-homogeneous KdV problem. This work is an extension of solvability results for a right-hand side f in Lebesgue space.
On local distance antimagic chromatic number of graphs disjoint union with 1-regular graphs
Authors: Nalliah M.
Published: May 2024

Let $G$ be a graph on $p$ vertices and $q$ edges with no isolated vertices. A bijection $f: V\rightarrow \{1,2,3,...,p\}$ is called local distance antimagic labeling, if for any two adjacent vertices $u$ and $v$, we have $w(u) \neq w(v)$, where $w(u)=\sum_{x\epsilon N(u)} {f(x)}$. The local distance antimagic chromatic number $\chi_{lda}(G)$ is defined to be the minimum number of colors taken over all colorings of $G$ induced by local distance antimagic labelings of $G$. In this paper, we obtained the necessary and sufficient condition for the local distance antimagic chromatic number of some disjoint union of graphs with 1-regular graphs equal to the number of distinct neighbors of its pendant vertices. We also gave a correct result in [Local Distance Antimagic Vertex Coloring of Graphs, https://arxiv.org/abs/2106.01833v1(2021)].%magic Vertex Coloring of Graphs, https://arxiv.org/abs/2106.01833v1
A note on local edge antimagic chromatic number of graphs
Authors: Hadiputra Fawwaz Fakhrurrozi , Maryati Tita Khalis
Published: May 2024

Let $G$ be a finite, undirected and simple graph. A bijection $f : V(G) \to [1,|V(G)|]$ is called a local edge antimagic labeling if for any two adjacent edges $uv,vw \in E(G), f(u) \ne f(w)$. The local edge antimagic chromatic number $\ch(G)$ is the minimum number of colors taken over all colorings induced by local edge antimagic labeling of $G$. In this paper, we investigate characterization of graphs $G$ with small number $\ch(G)$, relationship between local edge antimagic chromatic number $\ch(G)$ and edge independence number $\alpha'(G)$, and bounds of $\ch(G)$ for any graphs.
A transdisciplinary approach to address the exclusion processes of the food regime for Mexico’s small-scale fishers and farmers
Authors: Rivera-Núñez Tlacaelel , Arce-Ibarra A. Minerva
Published: May 2024

Mexico is one of the few countries that combine fishing and agricultural legacies. Despite the social importance and central role of food production, Mexican public policies have largely abandoned small-scale producers over the last four decades. Moreover, they have been relegated to the status of weakest link in the economic logic of the global food regime. Since Mexico signed the first North American Free Trade Agreement, small-scale fishers and farmers have faced five main problems: dismantling of means of production, erosion of organizational capabilities, disadvantageous commercial logic that limits access to favorable markets, westernization of diets, and frequent periods of food insecurity. This study addresses the following research question, how, in the face of the exclusion processes of the current food regime, the abandonment of public policies and erosion of most of the sectoral organizational capacities in Mexico, can small-scale fishers and farmers, as well as urban and rural consumers improve their productive, commercial and food problems within their living contexts? We introduced a novel transdisciplinary context-specific approach, based on our research experience in fishing and farming communities of the Yucatan Peninsula. Finally, we outline innovation niches that could lead to relocate regional food systems through complementarities between coastal and inland areas.
non-intrusive wave measurement device for accurate analysis and real-time data
Authors: Yusop Z. M. , Khan M. F. I. Y. , Jusoh M. A. , Albani A. , Ibrahim M. Z. , Yahya M. S. , Salleh M. H. M.
Published: May 2024

This research aims to enhance our understanding of wave climate in ocean wave studies by creating a buoy-based system equipped with gyroscopes and accelerometers. This system allows for accurate measurement and analysis of ocean wave profiles, with primary objectives including the conversion of wave heave motion into electricity and forecasting wave strength for coastal erosion evaluations. The study's main goals encompass the development and integration of gyroscopes and accelerometers into the buoy system, the deployment of the device to collect wave profile data, and the analysis of this data using specialized software. The research culminated in the successful creation of a buoy capable of accurately measuring wave acceleration, velocity, and displacement with an approximate accuracy of 90%. This significant accomplishment advances ocean wave research and offers vital insights for sustainable coastal management, ultimately bolstering our grasp of wave climate and promoting informed decision-making and effective strategies to counter coastal erosion.
Simulação do co-tratamento de resíduo de tanque séptico e esgoto doméstico em processo de lodos ativados
Authors: Pistorello Josiane , Benetti Antônio Domingues
Published: May 2024

O presente trabalho teve como objetivo avaliar o co-tratamento de resíduo de tanque séptico em uma estação de tratamento de esgoto composta por processo de lodos ativados, com aeração prolongada e dimensionada para uma vazão média de 180 m3/h. Utilizou-se o modelo matemático ASM1 que tem incorporado a remoção de matéria orgânica carbonácea, a nitrificação e a desnitrificação. No software WRc Stoat 5.0. foram realizadas simulações de quatro grupo de cenários, sendo que em cada grupo a Estação de Tratamento de Esgotos (ETE) operava com uma vazão fixa, alterando-se a parcela de resíduo de tanque séptico a ser tratada no sistema. Cada grupo de cenários seria equivalente a uma etapa de operação da estação ao longo dos anos, com o aumento crescente e gradativo da vazão de esgoto doméstico. Os resultados mostraram ser possível, em um sistema operando com uma vazão de 45 m3/h de esgoto doméstico, receber até 4.3 m3/h de resíduo de tanque séptico sem comprometer os padrões de lançamento dos parâmetros DBO, DQO, amônia e sólidos suspensos totais definidos na legislação ambiental. Para a ETE operando com 90 m3/h, 135 m3/h e 162 m3/h, as parcelas possíveis de serem recebidas de resíduo de tanque séptico de modo a atender aos padrões de lançamento definidos na legislação foram, respectivamente, 3.6 m3/h, 3.3 m3/h e 2.9 m3/h. Os resultados obtidos permitem concluir que é viável co-tratar resíduo de tanque séptico com esgoto doméstico e, ao mesmo tempo, atender aos padrões de lançamento exigidos pela legislação desde que respeitadas as vazões limitantes e as cargas máximas.
Nível de comprometimento, disponibilidade hídrica e principais usos consuntivos na Sub-Região Hidrográfica Guamá, Nordeste do Pará
Authors: Silva Anderson Abdon Santos da , Pessoa Francisco Carlos Lira , Ferreira Rafael da Silva , Ataide Lorena Conceição Paiva de
Published: May 2024

O estudo apesenta um panorama do nível de comprometimento e disponibilidade hídrica da Sub-Região Hidrográfica (SRH) Guamá, localizado na Região Hidrográfica da Costa Atlântica-Nordeste do Estado do Pará. Foi analisado as outorgas emitidas pela Secretaria de Estado de Meio Ambiente e Sustentabilidade do Pará (SEMAS) e considerando os dados de estações fluviométricas disponíveis no local obteve-se um balanço hídrico da região e o nível de comprometimento das respectivas sub-bacias que à compõem. Os resultados revelaram que, em uma perspectiva global, a SRH Guamá enquadra-se em uma condição de conforto hídrico, segundo os critérios da European Environment Agency e das Nações Unidas, uma vez que a vazão total outorgada para os diversos usos da água equivale a 1.57% da vazão de referência, considerando 70% da Q95%, conforme a Resolução nº 10/2010 do CERH. No entanto, quando se analisa particularizadamente, verifica-se que três sub-bacias da SRH Guamá demonstraram grau de comprometimento hídrico significativo, classificados como preocupante e crítico, indicando que a demanda pelo uso da água está atingindo níveis maiores do que a região suporta, logo, é necessário medidas de gestão adequadas para garantir o uso sustentável desse recurso. Portanto, este estudo fornece subsídios para a gestão de recursos hídricos em uma bacia hidrográfica no Estado do Pará, uma vez que o cenário de disponibilidade hídrica da SRH Guamá, reflete a realidade, em termos de dados e características econômicas e ambientais, das diversas bacias hidrográficas da região Norte do Brasil.
Smart Video Surveillance Using Deep Learning
Authors: Garad Nakshatra
Published: May 2024

Abstract: There is a lot of assessment happening in the business about video observation among them; the occupation of CCTV accounts has been blocked. CCTV cameras are put all around the spots for perception and security. In today's digital age, the increasing availability of data and advancements in computer vision have paved the way for numerous applications of object detection. This powerful technology has found its significance in various domains, including video surveillance and image retrieval systems. Object detection enables machines to identify and locate objects within images or video frames, providing valuable insights and aiding in decision-making processes. This article explores the applications, challenges, techniques, and future trends of object detection in the context of video surveillance and image retrieval systems. Object detection is a computer vision technique that involves identifying and localizing objects within images or video frames. Unlike image classification, which assigns a single label to an entire image, object detection goes a step further by detecting and delineating the individual objects present. It enables computers to comprehend visual data and interact with the world, much like humans do
Machine Learning Techniques for the Classification of Thyroid Disease
Authors: Vadar Parashuram S.
Published: May 2024

Abstract: In the healthcare system, dealing with a large amount of data is challenging. The techniques of machine learning are used in dealing with such data. As per NFHS – 5 statistics, thyroid diseases are increasing in India. Roughly 1 in 10 Indian adults suffer from a thyroid disorder. It has been expected that more than 42 million peoples suffer from thyroid disease. For the proper diagnosis of disease, it is vital to process the medical data accurately. This study classified thyroid disease cases into hyperthyroid, euthyroid, hypothyroid, and sick. This paper aims to inspect Logistic regression for multiclass categorizing the thyroid dataset. This logistic regression model is evaluated based on its precision, recall, F measure, ROC, RMS Error, and accuracy metrics. Based on the thyroid dataset, we find that logistic regression using the One-vs.-Rest heuristic is 85% accurate, while logistic regression using the multinomial is 86% accurate.