bluuebunny/crossref_metadata_2025 huggingface dataset:
The yellow-throated marten, Martes flavigula Boddaert, 1785in the southeast of the Amur Region
Authors:   Kingan State Nature Reserve, Arkhara, Amurskaya oblast, Russia, Babykina M.S.
Published: April 2023

All records of yellow-throated marten in the south-eastern part of the Amur Region since the middle of the 20th century till nowadays are presented. The area under consideration is out of the reproductive range of the species and only casual vagrants are recorded. However, local conditions are suitable for it, since at least one individual survived for three consecutive years in Khingan Nature Reserve both in summer and winter seasons.
Anniversaries in the Editorial Board - Irina Vasilievna Kartavtseva and Marina Vladimirovna Pavlenko
Authors:   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia, Sheremetyeva I.N. , Prozorova L.A. ,   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia
Published: April 2023

In July 2022, two members of the editorial board of the journal Biota and Environment of Natural Areas celebrated their anniversaries: July 3 – Irina Vasilievna Kartavtseva, July 16 – Marina Vladimirovna Pavlenko. Both of our wonderful colleagues have been working at the Federal Scientific Center for Biodiversity, Far Eastern Branch of the Russian Academy of Sciences since the 1970s – since the establishment of the Far Eastern Scientific Center (FESC) of the USSR Academy of Sciences. They are employees of the Laboratory of Evolutionary Zoology and Genetics of the Federal Scientific Center and their scientific experience is approaching half a century.
New data on cyanobacteria and algae in the Russian Far East. Part II
Authors:   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia, Nikulin A.Yu. , Nikulin V.Yu. ,   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia, Bagmet V.B. ,   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia, Allaguvatova R.Z. ,   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia, Abdullin Sh.R. ,   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia
Published: April 2023

Two new species for the Russian Far East, Anagnostidinema pseudacutissimum (Cyanobacteria) and Pseudomuriella engadinensis (Chlorophyta), were isolated from the forest soil of the Jewish Autonomous Oblast using an integrative approach. It is the first finding of the Cyanobacteria A. pseudacutissimum for the Russian Federation.
DHA and EPA are Able to Affect the Development of Stress-Induced Senescence
Authors:   Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia, M Janubova , H Gbelcová ,   Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia, K Konarikova ,   Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia, Z Szentesiova ,   Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia, I Zitnanova ,   Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Published: April 2023

Omega-3 fatty acids are an important part of biological membranes affecting their properties, cell signaling and gene expression. Senescence is an irreversible permanent cell cycle arrest accompanied by changes in cell morphology and physiology. We hypothesized that DHA as well as EPA could suppress the development of stress-induced premature senescence. To induce senescence, MRC-5 human lung fibroblasts were incubated with 100μM hydrogen peroxide/1hour. DHA (10 and 20 μM) or EPA (10, 20, 30 and 40 μM) were added to the cells for 24 hours either before (pretreatment) or after (postreatment) the induction of senescence. Only after postreatment with 10μM DHA or 20μM EPA, we detected slightly improved hallmarks of senescence - decreased percentage of SA-β-galactosidase positive cells, increased cell growth, reduced level of reactive oxygen species, cell cycle progression and decreased p21 protein expression. Based on our results we can conclude that DHA as well as EPA affect the development of peroxide induced senescence.
COVID-19 Associated Mucormycosis (CAM) - A Case Series from a Tertiary Care Hospital in India
Authors:   Medanta Institute of Education and Research, Gurugram, Haryana, India, P Sharma , MK Singh ,   Medanta Institute of Education and Research, Gurugram, Haryana, India, N Malhotra ,   Medanta Institute of Education and Research, Gurugram, Haryana, India, DK Sharma ,   Medanta Institute of Education and Research, Gurugram, Haryana, India, D Beniwal ,   Medanta Institute of Education and Research, Gurugram, Haryana, India, S Kataria ,   Medanta, The Medicity, Gurugram, Haryana, India, S Arora ,   Albert Einstein College of Medicine, Bronx, NY, USA, S Jariwala ,   Albert Einstein College of Medicine, Bronx, NY, USA, P Singh ,   Medanta Institute of Education and Research, Gurugram, Haryana, India, N Trehan ,   Medanta, The Medicity, Gurugram, Haryana, India
Published: April 2023

Purpose: Coronavirus disease (COVID-19) remains a health concern with new emerging challenges as rise of opportunistic mucormycosis infections in COVID-19 patients has been found to increase morbidity and mortality. Even though rare, COVID-19 associated mucormycosis has been reported from across the world. We present a retrospective cases series of 132 patients diagnosed as COVID-19 associated mucormycosis in a tertiary care hospital in North India during May 9th to 30th 2021. Materials and Methods: Our 1500 bed tertiary care hospital is one of the partners in the Mycotic Infections in COVID-19 (MUNCO) registry, Albert Einstein College of Medicine, Bronx, New York. Data were collected in the REDCap database. Profile of the patients has been presented according to demographic profile, comorbidities, laboratory parameters, ICU admission, oxygen support and treatment outcomes. Analysis of risk factors for mortality has been undertaken along with a prediction model for mortality. Result: The proportion of males and females was 72.7% and 27.3% respectively. The mean age of the study subjects was 53.1 years. The major comorbidity was Diabetes (57.6%) followed by Hypertension (40.9%) and Coronary artery disease (11.4%). About 13% patients used long term corticosteroid. Further, 70.5% patients required an ICU admission and 47.0% patients required oxygen support whereas ventilator requirement was for 13.6% patients. Overall death rate of mucormycosis patients was 16.7%. The risk factors identified for death were raised levels of CRP >73, Ferritin >358, SGOT >39 and Creatinine >1.15 as well as oxygen requirement. Conclusion: Clinicians must examine the possibility of concomitant fungal infection in COVID-19 patients especially who are geriatric or comorbid with Diabetes Mellitus. Those with raised levels of CRP, Ferritin, SGOT and Creatinine levels as well as those needing oxygen need to be vigilantly monitored to minimize the risk of mortality.
Double Transcrestal Sinus Lift Procedure with Collagen as Bone Void Filler Alone in Atrophic Maxilla: 5 Years Retrospective Radiological Study
Authors:   School of Dentistry, Saint Camillus International University of Health and Medical Sciences, Italy, R Crespi , P Toti ,   Tuscan Dental Institute, Versilia Hospital, Italy, U Covani ,   Tuscan Dental Institute, Versilia Hospital, Italy, G Crespi ,   Tuscan Dental Institute, Versilia Hospital, Italy, BC Brevi ,   Department of Maxillo-Facial Surgery, Hospital and University of Pisa, Italy, GB Menchini-Fabris ,   School of Dentistry, Saint Camillus International University of Health and Medical Sciences, Italy
Published: April 2023

Objectives: The present study aimed to investigate the effectiveness of transcrestal double-elevation of the maxillary sinus (TSFE) with an implant placement during the second-stage surgery in the maxillary areas with a residual alveolar bone less than 3mm. Materials and Methods: Patients with long-standing edentulous areas underwent double TSFE surgery involving a first transcrestal maxillary sinus floor augmentation with a collagen sponge to fill the intrabony cavity and a second osteotome-mediated sinus floor elevation by using an electromagnetic device and immediate implant placement. The radiographic changes in bone heightwere measured and compared during the different time intervals by nonparametric statistics with p < 0.01. Results: Twenty-eight patients were retrospectively selected for the study. A total of 42 implants were positioned in 28 augmented sinuses. After the first TSFE surgery, no minor swelling of gingival mucosa, no mucositis, or flap dehiscence with suppuration was found. After three months a second TSFE with simultaneous implant placement was performed; four patients experienced minor nasal bleeding. Significant increases in the bone height had been respectively reported for the first (from 2.3±0.2 to 9.5 ± 0.3 mm) and second surgeries with p-values less than 0.0001 and an overall bone height measured 5 years after the first surgery of 12.2±0.3 mm. Conclusion: The present study suggested to clinicians the possibility of osteotome double sinus lifting and grafting with highly absorbable collagen material, generally used as a haemostatic agent alone in case of residual bone height less than 3 mm.
Hydrogen production by a fully de novo enzyme
Authors: Berglund Sigrid , Bassy Clara , Kaya Ibrahim , Andrén Per , Shtender Vitalii , Magnuson Ann , Glover Starla
Published: April 2023

Molecular catalysts based on abundant elements that function in neutral water represent an essential component of sustainable hydrogen production. Artificial hydrogenases based on protein-inorganic hybrids have emerged as an intriguing class of catalysts for this purpose. We have prepared a novel artificial hydrogenase based on cobaloxime bound to a de novo three alpha-helical protein, α3C, via a pyridyl-based unnatural amino acid. The functionalized de novo protein was characterized by UV-visible, CD, and EPR spectroscopy, as well as MALDI spectrometry, which confirmed the presence and ligation of cobaloxime to the protein. The new de novo protein produced hydrogen under electrochemical, photochemical and reductive chemical conditions in neutral water solution. A change in hydrogen evolution capability of the de novo enzyme compared with native cobaloxime was observed, with tunover numbers around 80% for that of cobaloxime, and hydrogen evolution rates of 40% of that of cobaloxime. We discuss these findings in the context of existing literature, and our study contributes important information about the functionality of cobaloxime HER catalysts in protein environments, and the feasibility of artificial enzymes to the field of artificial metalloenzymes. Small de novo proteins as enzyme scaffolds have the potential to function as upscaleable bioinspired catalysts thanks to their efficient atom economy, and the findings presented here show that this type of novel enzymes are a possible product.
Bridging physical intuition and hardware efficiency for correlated electronic states: the local unitary cluster Jastrow ansatz for electronic structure
Authors: Motta Mario , Sung Kevin J. , Whaley K. Birgitta , Head-Gordon Martin , Shee James
Published: April 2023

A prominent goal in quantum chemistry is to solve the molecular electronic structure problem for the ground state energy with high accuracy. While classical quantum chemistry is a relatively mature field, the accurate and scalable prediction of strongly correlated states found, e.g., in bond breaking and polynuclear transition metal compounds remains an open problem. Within the context of a variational quantum eigensolver, we propose a new family of ansatzes which provides a more physically appropriate description of strongly correlated electrons than unitary coupled cluster with singles and doubles excitations, with vastly reduced quantum resource requirements. Specifically, we present a set of local approximations to the unitary cluster Jastrow wavefunction motivated by Hubbard physics. The resulting ansatz removes the need for SWAP gates and can be tailored to arbitrary qubit topologies (e.g., square, hex, heavy-hex). Our ansatz is well-suited to take advantage of continuous sets of quantum gates recently realized on superconducting devices with tunable couplers, while retaining a unique level of physical transparency and interpretability. As the capabilities of quantum computing devices continue to progress, we expect that the local cluster Jastrow ansatz to be a natural choice to encode both statically and dynamically correlated electronic wavefunctions.
On the non-bonding valence band and the electronic properties of poly(triazine imide), a graphitic carbon nitride
Authors: Burmeister David , Bojdys Michael Janus , Eljarrat Alberto , Guerrini Michele , Röck Eva , Plaickner Julian , Koch Christoph T. , Banerji Natalie , Cocchi Caterina , List-Kratochvil Emil
Published: April 2023

Graphitic carbon nitrides are covalently-bonded, layered, and crystalline semiconductors with high thermal and oxidative stability. These properties make graphitic carbon nitrides potentially useful in overcoming the limitations of 0D molecular and 1D polymer semiconductors. In this contribution, we study structural, vibrational, electronic and transport properties of nano-crystals of poly(triazine-imide) (PTI) derivatives with intercalated Li- and Br-ions and without intercalates. Intercalation-free poly(triazine-imide) (PTI-IF) is corrugated or AB stacked and partially exfoliated. We find that the lowest energy electronic transition in PTI is forbidden due to a non-bonding uppermost valence band and that its electroluminescence from the π-π* transition is quenched which severely limits their use as emission layer in electroluminescent devices. THz conductivity in nano-crystalline PTI is up to eight orders of magnitude higher than the macroscopic conductivity of PTI films. We find that the charge carrier density of PTI nano-crystals is among the highest of all known intrinsic semiconductors, however, macroscopic charge transport in films of PTI is limited by disorder at crystal-crystal interfaces. Future device applications of PTI will benefit most from single crystal devices that make use of electron transport in the lowest, π-like conduction band.
Social media influencer’s influence on the travel decisions with respect to Kaveri delta region
Authors: T Priyanga , J Ashokkumar
Published: April 2023

After the advent of social media applications, the consumers of tourism sector rely on the social media influencers information while planning trip to a particular destination. Many previous studies were focused on the effectiveness of social media interactions in spreading content about tourism destinations. The current was aimed to examine the role of social media influencers towards attracting the social media users to visit the Tourist spot with respect to the Kaveri delta region of Tamil Nadu. The study intended to examine the consumers Pre-Purchase, Purchase decision and post-Purchase decision while scheduling a trip based on the inspiration from the social media influencer. The research instrument was circulated using social media applications and 278 valid responses was collected using Purposive sampling method. The responses were analyzed using Microsoft Excel, SPSS and Amos. The Findings shows that the research instrument was reliable and valid. Further, the result of the Path analysis demonstrates that the social media users are influenced by the social media influencers while planning their trip to the Tourist spot at the Kaveri delta region of Tamil Nadu. The findings revealed that the social media users are not willing to post their post visit experiences from the Tourist spot which could influence the future travelers.
Formation and development of the language training methodology for foreign students at classical universities. Part 3. Teaching the Ukrainian language
Authors: Ushakova N. , Trostynska O. , Kushnir I.
Published: April 2023

The article is another part of a series of scientific and methodical studies on the formation and development of language training methods for foreign students at classical university. Previous research has analyzed the formation of the conceptual foundations of language training of educational migrants of various study profiles, the history, principles, and features of language education of students of higher education of non-linguistic and philological specialties based on the activity of the Language Training Department 1 of V. N. Karazin Kharkiv National University.

The third part is devoted to the analysis of problems and achievements of the department in teaching Ukrainian as a foreign language. The gradual transition to teaching the state language was carried out from the end of the 90-s of the XX century. This required a rethinking of methodological approaches and principles, the development of principles and provisions of the methodology of teaching Ukrainian as a foreign language, and educational and methodical support of the teaching process.

The research tools of the article as a part of the series are the method of systematic analysis of the scientific work on the linguistic problems of the Ukrainian language done by the department’s specialists, characteristics of dissertation studies, scientific publications, didactic work, and their methodical implementations. The main stages of the formation of the methodological foundations of teaching Ukrainian as a foreign language at classical university, the optimal methods of teaching language aspects, the formation of speech activity skills, the intercultural communication are also highlighted in the paper.

The authors defined the main scientific and methodological principles and components of the educational process organization (in particular, the development of the program as one of the main factors in the creation of methodical and informational support for language training of foreign students studying at Ukrainian universities). The authors relied on the concept of language education of foreigners presented in the first article of the series, the structure of the modern educational paradigm, analysis of the influence of the competence approach on curricula creation, and professionally oriented language training of foreigners.

The article also contains an analysis of some educational and methodical Ukrainian language guides and manuals that have been used for forming components of communicative competence of educational migrants during language acquisition in a new social-cultural environment, in the academic space of a Ukrainian classical university.
Ukrainian Education in Wartime: Challenges and Problems
Authors: Bondarenko Hanna
Published: April 2023

The article surveys the most acute problems and challenges that the Ukrainian educational system has faced since February 24, 2022 as a result of Russian aggression. For a certain time, the education of children and youth generally took a back seat to the basic task of survival. A significant proportion of Ukrainian children, especially displaced persons and refugees, had to miss school in the spring semester. However, despite the ongoing hostilities, educators are heroically continuing their work, even from bomb shelters. The most important problem facing school education is its transition from the domain of the state to the civil or personal sector. A child's education and its quality now primarily depend on the parents, their efforts and conviction in the need for education. The insufficient level of state funding negatively affects the entire education system, leading to a decrease in the number of teachers, lack of new curricula, lack of printed textbooks and educational materials, etc. Educational standards also suffer from the online format, which mostly presupposes self-teaching and requires self-discipline from students. Students lose motivation, and sometimes (especially at the elementary-school level) do not understand and are not able to absorb learning at all. The war is not over yet, and Ukrainian children and young people continue to live in constant psychological tension, with deep psychological trauma and fears caused by the war. A serious challenge for all educators and students is the impossibility of consistently teaching and attending online classes due to planned and emergency power outages that can last for many hours at a time. However, the search for a new format in which the Ukrainian educational system can be rebuilt and restructured is already underway. There is an active discussion of possible solutions to the problems of the Ukrainian educational system both at the international level (see for instance the International Conference on the Restoration of Ukraine, Switzerland – URC 2022) and within the country.
“We Will Discuss the Future and Dream Together”: Cultural and Artistic Life and the Museumification of Urban Space in Wartime Kharkiv
Authors: Vovk Olha
Published: April 2023

The article describes the experience of Kharkiv artists (both professional and amateur) who continued to live and create in the front-line metropolis after February 24, 2022. Attention is also given to several events that physically took place entirely or in part outside Kharkiv, but were aimed at the presentation of the city, with their organizers and target audience directly connected with it. The article shows that the making of fine art went on in Kharkiv during this time, musical works were performed, and theatrical productions were premiered. Both individual artists and collectives launched creative initiatives, and art festivals were held. Artistic practices influenced the life of the metropolis and became one of the forms of recording the memory of war. The author points out that creative work under conditions of persisting military danger had a psychotherapeutic effect on the participants, helping them to get through traumatic situations and supporting morale. Artists reflected in their work events they witnessed firsthand, and also occasionally used material objects generated by the war (such as shell fragments) to create new artistic artifacts — examples of “trench art.” Importantly, creative acts took place in iconic and recognizable city locations — for instance, at subway stations or near damaged historical and architectural landmarks. The article investigates the role of cultural and artistic practices in the process of the museumification of the urban space of Kharkiv during the full-scale Russian aggression. It is shown that already in the first months of the war, artists began to reflect on the fact that their creative practices will be included in future museum exhibits, as well as contribute to the emergence of new “sites of memory” in the urban space of Kharkiv.
Tránsito del pensamiento crítico: una mirada al proceso de formación a distancia y su papel en la educación de la primera infancia
Authors: Alarcón Cruz David Fernando
Published: April 2023

En esencia, el capítulo propone un diálogo entre el pensamiento crítico, la formación y la praxeología presentes en el modelo educativo de la Corporación Universitaria Minuto de Dios – UNIMINUTO modalidad a distancia y su papel en el educador de la primera infancia. Para comenzar, entenderemos al pensamiento crítico como una categoría en desarrollo constante, donde los procesos de formación aportan en la consolidación de dicho concepto en el ser humano y su aporte en la capacidad de indagar e ir más allá en el desarrollo de su aprendizaje.
Hacia una cultura de alfabetización académica universitaria Conceptos y estrategias para la comprensión de textos académicos
Authors: Pulgarín Rodríguez Maira Alejandra , Fierro Chong Bárbara Maricely , Ossa Taborda Erica María , García Caballerro Ángela María , Meneses Castañeda María Erica
Published: April 2023

Hacia una cultura de alfabetización académica universitaria, constituye la sistematización de un proceso de investigación llevado a cabo, cuyo propósito fundamental estuvo dirigido a la caracterización de los procesos de comprensión de textos de los estudiantes universitarios, así mismo, presenta diversas estrategias para fortalecer las competencias en el campo académico desde la lectura y escritura académica. A su vez, recopila desde un componente científico académico una serie de herramientas que en el campo universitario se deben implementar a partir de la lectura y escritura contemporánea que, con los cambios y avances tecnológicos, es necesario alfabetizar a los estudiantes desde las competencias de lectura y escritura para así enfrentarse a la comprensión de diversos tipos de textos los cuales son derivados de la generación de la información. A lo anterior, cabe destacar que el libro producto de investigación, valora esos procesos de lectura y escritura, como prácticas sociales, lo cual aportan significativamente en las competencias de los estudiantes universitarios y les permitirá a futuro adquirir un discurso académico con rigor científico en el que se comprenderá en cada uno de los capítulos esos procesos de producción mediados por el análisis y la reflexión sobre la lengua, su saber, sus estructuras y funcionalidad para cada contexto con las diferentes estrategias que se abordarán en el presente libro lo cual es menester para los programas de formación en pregrado que hacen parte de la Universidad y así contribuir al cumplimiento del proyecto educativo institucional en la formación de profesionales competentes.
Eksistensi Sanksi Administratif Bisnis Digital dalam Perspektif Economic Analysis of Law
Authors: Kurniawan I Gede Agus , Samsithawrati Putu Aras , Lulo Lourenco De Deus Mau
Published: April 2023

Penelitian ini berfokus pada analisis atas isu hukum yaitu konflik aturan antara Pasal 65 ayat (6) UU Perdagangan dengan Pasal 80 PP PMSE terkait dengan sanksi administratif dalam perspektif Economic Analysis of Law (EAL). Hal ini karena dalam perspektif EAL, peran pemerintah penting sebagai regulator atas berbagai perkembangan bisnis yang ada. Penelitian ini merupakan penelitian hukum normatif dengan pendekatan konseptual dan perundang-undangan. Hasil penelitian menegaskan bahwa problematika hukum terkait sanksi administratif dalam bisnis digital adalah adanya konflik hukum terkait sanksi administratif dalam bisnis digital yaitu sebagaimana dalam ketentuan Pasal 65 ayat (6) UU Perdagangan dengan Pasal 80 PP PMSE. Berdasarkan asas lex superior derogate legi inferior ketentuan Pasal 65 ayat (6) UU Perdagangan lah yang berlaku. Hal ini dikarenakan berdasarkan ketentuan Undang-Undang No. 12 Tahun 2011 Tentang Pembentukan Peraturan Perundang-Undangan (UU P3), maka secara hierarkis kedudukan UU Perdagangan adalah lebih tinggi dari PP PMSE. Hal ini berimplikasi bahwa setiap pelaku usaha bisnis digital yang tidak mencantumkan informasi atau data yang wajib dituangkan dalam bisnis digital sebagaimana dalam Pasal 65 ayat (4) UU Perdagangan, maka dikenakan sanksi administratif berupa pencabutan izin.   Sanksi administratif bisnis digital dalam perspektif EAL adalah tidak memenuhi aspek keberdayagunaan (utility), nilai (value), serta efisiensi (efficiency). Hal ini dikarenakan Pasal 65 ayat (6) UU Perdagangan justru menempatkan sanksi administratif berupa pencabutan izin secara langsung sebagai langkah utama, sehingga dapat berimplikasi pada iklim bisnis yang kondusif di masyarakat. Dengan demikian, mengacu pada analisis EAL maka ketentuan yang relevan adalah diberlakukannya sanksi administratif secara berjenjang sebagaimana dalam Pasal 80 PP PMSE. Oleh karena itu, ke depan perlu adanya revisi ketentuan dalam Pasal 65 ayat (6) UU Perdagangan sehingga dikonstruksikan sesuai dengan rumusan Pasal 80 PP PMSE.
Modernizmden Postmodernizme Aile (Family From Modernism to Postmodernism)
Authors: Hatipler Mustafa
Published: April 2023

Sanayi Devrimi ile başlayan süreç, insanlığın daha önce yaşadıklarını kapsıyor olsa da büyük bir değişim sağladığı yadsınamaz. Bu değişim, başta aile olmak üzere ekonomi ve hukuk gibi bütün toplumsal kurumları derinden etkilemiştir. Özellikle aile kurumu, yaşanan değişim ve gelişime paralel olarak bazen küçülmüş bazen genişlemiştir. Aile kurumunda, modernizmin başlangıcından sonlarına doğru, küçülme ve genişleme şeklinde tezahür eden değişim; postmodernizm sürecinde var olma ve yok olma boyutunda bir değişim sürecinin içine girmiştir. Aile hem bir grup hem de bir toplumsal yapı olmak itibarıyla, sosyal hayatın en temel unsurlarından biridir. Aileyi bu denli önemli kılan husus, onun sosyalleşmenin ilk aşaması ve toplumsal norm ve değerlerin öğrenildiği ilk süreç olmasındandır. Toplumsal norm ve değerler bir yanıyla topluma ait hususlar olsa da diğer yanıyla insana ait değerlerdir. Aile kurumunda yaşanacak olumsuz değişimin toplumsal yapının bütün unsurlarını etkileme ve değiştirme gücüne sahip olduğu bilinen bir gerçektir. Bu noktada, ailede yaşanacak olumsuz değişimin tedavisi aynı zamanda toplumsal yapının da tedavisi anlamını taşımaktadır. Aile kurumu, toplumu doğurma, büyütme ve kültürel değerleri gelecek nesillere aktarma misyonuna sahiptir. Aile kurumunun bu misyonunu yerine getirme becerisi ancak güçlü bir yapıya ve fonksiyonel özelliklere sahip olmasıyla mümkündür. Gücünü kaybetmiş ve fonksiyonel yapısını yitirmiş bir aile yapısının, kültürel değerleri aktarma misyonu bir yana, toplumu doğurma ve büyütme misyonunu dahi icra edemeyeceği çok açıktır. Gelinen noktanın önemi, aile ile ilgili sorunların tespitini ve tedavisini acil kılmaktadır. Aile kurumu ile ilgili olarak, zamanında dökülen bir kova suyun bir yangını önleyeceği gerçeği içinde hareket etmek bir tercih değil bir zorunluluktur.
I. ve II. Meşrutiyette Bürokratik ve İdari Yapı (I and II. Bureaucratic and Administrative Structure in the Constitutional Monarchy)
Authors: Kılıç Fethi , Kılıç Ümmügülsüm
Published: April 2023

Osmanlı İmparatorluğu’nun hasta adam kimliğinden kurtulup bir diri olduğunu göstermesi için 1876 Anayasası Sultan II. Abdülhamit tarafından Mithat Paşa ile birlikte hazırlanmış Ferman Anayasası olarak yürürlüğe girmiştir. 1876 Anayasası’nın ilan edilmesinin hem içeride hem de dışarıda olumlu yansımaları olmuştur. 1876’da yönetim şekli meşrutiyet olup bu yönetim süreci II. Meşrutiyete kadar devam etmiş ve II. Meşrutiyette meşruti monarşiden parlamenter sisteme geçiş yaşanmış ve padişahın yetkileri yürütme organı lehine kısıtlanmıştır. Padişah- saltanat adeta sembolik olarak var olup yönetim yürütmenin hakimiyetinde devam etmiştir. I. Meşrutiyette alışılagelen Osmanlı bürokrasisi doğal olarak değişim gösterip Batı bürokrasisini örnek alarak değişmiştir. Ne yazık ki bürokratik ve idari yapı başlangıçtaki güçlü varlığını zamanla kaybetmiş ve sonunda imparatorlukta sona gelinmiş ve idari yapıda ön görülmeyen değişiklikler olmuştur. Yaşanılan iç olaylar ve komşu ülkelerde olan savaşlar sebebiyle bürokrasi ve idari yapı farklı çözüm yolları aramaya koyulmuştur. Bu farklı çözüm yolları bürokratik ve idari yapının bölünmesine ve değişmesine sebebiyet vermiştir.
Fetüs Beyin Dokularının 3B U-Net ile Segmentasyonu ve Gestasyonel Yaşın Segmentasyon Performansına Etkisi
Authors: AKYÜZ Uğurcan , ÖZCAN Tayyip
Published: April 2023

Gebelik esnasında fetüs beyninde, çevresel veya genetik etmenlerden kaynaklanan bozuklukların ilerleyen yaşlarda otizm, hiperaktivite ve bipolar bozukluklar olarak ortaya çıktığı düşünülmektedir. Fetüs beyin dokularının yapısal analizi, dokuların büyüklükleri ve şekilleri hakkında bilgi sağlayarak bu hastalıkların etiyolojisinin araştırılmasına yardımcı olmaktadır. MR (manyetik rezonans) ve ultrason fetüs beyin dokusu analizi için en sık kullanılan iki görüntüleme tekniğidir. Özellikle MR görüntülemede, fetüs beyin dokuları net bir şekilde görülebilmesine rağmen bu görüntülerin yapısal analizi zaman alıcı bir iştir. Hızla gelişen ve değişen fetüs beyin dokuları, haftalık veya aylık periyotlarla, elle veya yarı-otomatik şekilde gerçekleştirilen MR analizinin yapılmasını zorlaştırmaktadır. Bu araştırmada, 3B U-Net ile MR görüntüleri üzerinde yedi farklı fetüs beyin dokusunun tam otomatik segmentasyonu gerçekleştirilmiştir. FeTA2021 veri seti, erken, orta ve geç gestasyonel yaş gruplarına bölünerek her bir yaş grubu için farklı 3B U-Net modelleri eğitilmiş ve segmentasyon performansı analiz edilmiştir. Gestasyonel yaş gruplarına göre sırasıyla ortalama 0,83, 0,91 ve 0,92 Dice skoruna ulaşılmıştır.
Экономика взаимодействия
Authors:   Московский государственный университет им. М.В. Ломоносова, Морозов В.А.
Published: April 2023

В учебном пособии представлен методический материал описания совместимости социально-экономических систем на основе принципов и подходов их взаимодействия, а также общих и разделяемых ценностей. Структурированы экономическое мышление на основе социально-экономической совместимости и формы взаимодействия субъектов/объектов управления. Выработаны подходы и механизмы «экономики взаимодействия» различных ее видов. Раскрыта роль многообразия ценностных факторов в экономике, за-дающих общий вектор ее развития. Выработаны приоритетные направления развития совместимых состояний субъектов и объектов, формирующих социально-экономическую среду с участием культурно-мировоззренческих и социально-политических институтов общества. Предложена методика оценки эффективности развития регионов, а также показатели уровней совместимости для устойчивого взаимодействия субъектов/объектов территорий. По каждой из предложенных тем приводится литература. В пособие включён список контрольных (экзаменационных) вопросов и заданий. Содержание работы учитывает профиль экономического факультета МГУ. Для студентов магистратуры, обучающихся по направлениям подготовки «Экономика», «Менеджмент», «Финансы и кредит», изучающих основы формирования социально-экономических систем и их взаимодействия.
Coğrafi bilgi sistemleri tabanlı analitik hiyerarşi yöntemi kullanılarak Konya il merkezinde teknoloji geliştirme bölgesi için yer seçimi
Authors: MEŞİN Vehbi , DEMİR Vahdettin
Published: April 2023

Teknoloji gelişme bölgelerinin yer seçimi, son yıllarda dünyada ve ülkemizde önemli konular arasında yer almaktadır. Teknoloji gelişme bölgelerinin tüm paydaşlara yakın olması bilgi ve teknolojinin transferini kolaylaştırmakta ve etkin iş birliklerinin ortaya çıkmasını sağlamaktadır. Bu nedenle bu bölgelerden en verimli şekilde yararlanabilmek için yer seçiminde en uygun alanların belirlenmesi oldukça önemli bir araştırma konusudur. Bu çalışmada Konya il merkezinde teknoloji geliştirme bölgesi için uygun alanlar Coğrafi Bilgi Sistemleri (CBS) ve Çok Ölçütlü Karar Analizi (ÇÖKA) yöntemlerinden Analitik Hiyerarşi Yöntemi (AHY) kullanılarak belirlenmiştir. Analizde kullanılan kriterler ve kısıtlar; teknolojik, ekonomik ve çevresel açıdan değerlendirme yapılarak belirlenmiştir. Veriler CBS ortamına aktarılmış, kriter ağırlıkları belirlenmiş ve ikili karşılaştırma yöntemi kullanılarak teknoloji gelişme bölgelerine ait harita oluşturulmuştur. Çalışmanın sonucunda, Konya il merkezinde toplam 8 adet ekilebilir arazi (422.763 m²), 8 adet mera (157.845 m²), 23 adet mevcut kullanımı olmayan arazi (178.978 m²) ve 21 adet süreksiz yoğunluklu kentsel doku alanı (245.766 m²) Teknoloji Geliştirme Bölgesi’nin kurulabileceği uygun alanlar olarak belirlenmiştir. Böylece CBS tabanlı AHY’nin Teknoloji Geliştirme Bölgesi’nin kurulabileceği yer seçimi problemlerinde etkin bir şekilde kullanılabileceğini ortaya konmuştur.
Histopathological and Molecular Analysis of Thyroid Papillary and Medullary Carcinoma in a Samples of Iraqi Patients
Authors: Jabbar Rebah Najah
Published: April 2023

This study included, 1500 patients showing thyroid cancer (500 female and 1000 male), were selected to determine the histopathic disorder and DNA aberration in thyroid tissue compared with 200 healthy people of both genders in four years study (2006 – 2010). Histopathological examination of thyroid disorders showed the presence of papillary carcinoma in patients with goiter and most of benign tumors appeared in female patients and were less in male. Cancer study showed that cancer studied were mostly of papillary carcinoma, whereas medullary carcinoma was less frequent. DNA analysis using hexamere RAPD primers from patients with thyroid carcinoma and thyroid disorders compared with healthy persons showed different patterns analyzed as follow: Patients with hyper and hypo thyroidism showed no DNA aberration when compared with each other and with healthy persons, whereas different patterns of DNA electrophoresis were noticed with patients with cancer cases. wThis pattern showed that patients with medullary and papillary carcinoma showed bands in location significantly different from those patients with thyroditis and healthy subjects. Further analysis with specific primers showed significant change in bands at location amplified compared with healthy persons suggesting a sever change in DNA sequence in patients with carcinomas which may attributed to BRAF mutation.
The Effect of Beta Glucan Extract of Saccharomyces Cerevieses on Cancer Cell Growth In vitro
Authors: Jabber Ali J.
Published: April 2023

This study was designed to evaluate the anticancer Effects of the beta glucan (ß- glucan ) extract of the Saccharomyces cerevieses on cancer cell lines . In vitro study was performed on two cancer cell lines (murine mammary adenocarcinoma AMN-3 cell line) and rat emberyogenic fibroblast (Ref) as normal cell line. Periods of exposure of cell lines were measured at 24-hours, 48-hr, and 72-hr in a microtitration plate under complete sterile conditions. Different concentrations starting from (5,50,500, 1000) µg/ml of two fold dilution for extract were prepared and tested on each cell lines, The extract showed concentration and time dependence growth inhibitory effects, and the highest effect was obtained from beta glucan extract at higher concentrations after 48 hr. of exposures on AMN3, that the higher concentrations gave a significantly (P<0.05) and the higher inhibition growth rate of cells were increased at 24 hours.
Complications of HBV, HCV and HIV Infections in Patients with Coolyze Anemia in Baghdad
Authors: Fadhil Rushdi S.
Published: April 2023

This study was carried out to evaluate some virological parameters: hepatitis B surface antigen (HBS Ag), Anti-hepatitis C virus antibody (Anti-HCV Ab.) and Human immunodeficiency virus ( HIV ) in β-Thalassemia . Those were analyzed in the period from first of October 2010 to May 2011. The study included: 200 patients with β-Thalassemia referred to the Ibn-AlBalady hospital center and Al-Karamh Hospital Center ,100 patients from each center and 50 cases of children infected with other mild diseases as a control for β- Thalassemia group from those attending the General Pediatric Hospital). Most of Thalasseamic patients were distributed between (2–35) years of age .In this study we found that the Enzyme linked Immuno-Sorbent Assay (ELISA) test showed that 2.5% of Thalassemia patients were infected with hepatitis B , 21% of them had hepatitis C virus infection . On the other side the patients showed negative results for HIV .
Cytotoxic effect of esculetin on myeloma and myelogenous leukemic cells.
Authors: Ali Khedhir Hassan
Published: April 2023

The cytotoxic effect of Esculetin to mouse myeloma and human acute myelogenous leukemia cells invitro was evaluated. Tumor cells exposed to Esculetin in culture showed an exponential cytotoxic responses. A decreased viabilities of both leukemic cells were noticed with 20, 40 and 80 µg / ml Esculetin. Besides, myeloma cells showed a progressive depletion of viability when exposed continuously for 1,2,3 and 4 days, whereas , pretreatment of myeloma cells with Esculetin for 1,2,4 and 24 h followed by removal of the chemical and culturing the cells for 3 days indicated that the time the cells much effected was 24 h post exposure. At this exposure time , exposure to 10 µg / ml decreased the able cell number to 24.66 × 10-4 cells / ml versus 62.66 × 10-4 cells / ml in the control . t – test = 5.16 , p = 0.007 95 % CI = 17.5 – 58.5. Like wise , a 20 µg / ml concentration of esculetin decreased viable cells number to 23.5 × 10-4 cells / ml versus 62.66 × 10-4 cells / ml of control. T-test 7.39 , P = 0.002. 95 % CI = 24.5 – 53.8. The efficiency of Esculetin in protecting mice implanted with syngeneic myeloma was studied . The results of invivo experiment demonstrated that the chemical could protect mice from lethal dose of the experimentally implanted tumor . The protection value reached 66.7 % in animals treated with 200 or 400 µg Esculetin for 10 consecutive days. For 200µg drug plus myeloma versus myeloma only , chi – square value was 3.086 p=0.08 and 95% CI = 0-2.4. However , at 400 µg drug plus myeloma versus myeloma only , the chi – square analysis showed a value of 4.17 , P=0.04 95% CI = 0.02 – 1.3. Besides , the survival of the animals was increased . The therapeutic relevance and speculated mechanism of Escletin cytotoxic effects are discussed. In conclusion , it seems that esculetin has antiproliferative effects to mouse myeloma and to human myelogenous leukemia cells.
ÖĞRETİMDE DEĞİŞEN MEKÂN VE YENİ YATAY ONTOLOJİ
Authors: ATEŞOĞLU Nadir
Published: April 2023

Mekâna sahip olmak bir etkileşim biçiminde temel öğelerden biridir. Öğretim mekânın yüz yüze veya uzaktan-dijital bir biçimde kullanımı akademisyen ve öğrenciler arasındaki iktidar ilişkisini derinden etkilemektedir. Halihazırda yüz yüze öğretimde kullanılan derslik ve amfiler -yapısı gereği- kapatma, gözetleme ve denetlemeye elverişli mekânlardır. Öğretimde mekân bu şekilde kullanıldığında taraflar arasındaki ilişkiyi zorunlu olarak ve belirli bir ölçüde hiyerarşik bir biçime dönüşmektedir. Öte yandan günümüzde öğretim mekânı sanal bir yöne doğru evrilmektedir. Dijitalleşme ve onun beraberinde getirdiği bağlantısallık, sahip olduğu sanallık ve somut bir mekân tanımazlık nedeniyle yapısı gereği hiyerarşik ilişki biçimine uygun değildir. Bu durum bir taraftan eskisine göre çok daha yatay ve bağlantısal bir öğrenme anlamına gelmekte ve diğer taraftan öğrenci ve akademisyenler arasındaki ilişki biçimini yeniden yapılandırmaktadır. Bu çalışmada öğretimin sanallaşmasıyla, üniversitelerde öğrenci ve akademisyenler arasındaki iktidar ilişkisini nasıl değişebileceği tartışılmaktadır.
Solid Dispersion of Acetosal Using Polyvinyl Pyrrolidone (PVP) K-30 in Tablets with Direct Compressing Method
Authors: Khasanah Khuswatun , Nawangsari Desy , Kusuma Ikhwan Yuda
Published: April 2023

Acetosal is classified in the Biopharmaceutical Classification System (BCS) class II (low solubility, high permeability). Low solubility causes a decreased dissolution rate. Polyvinyl pyrrolidone (PVP) K-30 is an inert carrier easily soluble in water and can influence the solubility of a drug substance. Efforts to increase the solubility of acetosal make a solid dispersion system. This study aims to determine the effect of the solid dispersion system of acetosal: PVP K-30 on dissolution rate, the ratio of the solid dispersion with the best dissolution rate, and the physical properties of acetosal tablets formed in the dispersion system. Solid dispersions using the dissolving method with variations in the concentration of acetosal: PVP K-30 1:1, 1:3, and 1:5. The results of the dissolution test of acetosal in solid dispersion powder, i.e., PVP Formula 1:5, which has the highest dissolution percentage compared to formula 1:1 and 1:3 with the concentration this formula was 140.96 mg, dissolution percentage was 28.19±0,63% in 30 minutes. Statistical results by ANOVA test show a significant difference of 0.044 (p<0.05). The physical properties of tablets with a dispersion system show higher addition of PVP K-30. This result is related to slower disintegration time and lower friability.
Трансформация бизнес-моделей генерирующих компаний на российском электроэнергетическом рынке
Authors: Горгишели М.В. , Волкова И.О.
Published: April 2023

В статье рассматривается трансформация бизнес-моделей российских генерирующих компаний, являющаяся ответом на новые вызовы. Пандемия коронавируса, санкционный пакет стран Запада оказали влияние на глобальные тренды, ранее действовавшие на электроэнергетическом рынке России, и сформировали целый ряд ограничений. Показаны общие негативные последствия данных событий: разрыв прежних цепочек ценности, необходимость поиска новых источников инвестиций, возможное ухудшение состояния активов, замедление темпов цифровизации. Описаны направления изменений бизнес-моделей отдельных групп генерирующих компаний в рамках поиска новой устойчивости.
«Scottish colorists» in the art of European modernism: problems of context and style
Authors:   federal state budget educational institution of higher education «Saint Petersburg State University of Culture», Isaeva Olga Anatolievna
Published: April 2023

The article explores a complex and insufficiently studied phenomenon in the visual art of Scotland – Scottish colorism, and, accordingly, the work of masters of its circle. Colorism does not limit its appeal to various kinds of artistic trends, which creates the problem of determining both the stylistic commonality and the artistic background in the formation of the creative manner of Scottish colorists; another difficulty is to determine the contextual boundaries of this phenomenon. This article, therefore, is devoted to resolving these issues in order to outline the place and role of Scottish colorists in European pictorial practices.
Methodology of museification of paleontological heritage IN SITU
Authors:   federal state budget institution of higher education «Kemerovo State University of Culture and Art», Abramova Polina Valerievna , Feofanova Olga Aleksandrovna ,   f Kuzbass Museum of Local History
Published: April 2023

The purpose of the article is to determine approaches to the museification of paleontological heritage objects on site within the framework of current museological landscape and environmental approaches. In domestic practice, natural heritage is considered in the context of cultural, and the problems of its preservation are investigated from the standpoint of conservation measures. The reasons for the low museification of natural heritage objects are revealed. Methods of preservation of paleontological objects by museum means are developed on the basis of the well-established methodology of museological practice of archaeological heritage museification, optimal ways of their exposition interpretation are determined. It is revealed that the main method of museification of paleontological objects is conservation, the identified finds can be exhibited in a separate building or directly in situ, in this case it is necessary to erect a glass dome or pavilion over the object. To enhance the attractiveness of the object in the exhibition space, graphic or virtual reconstruction can be used. Based on this technique, an open-air museum can be created, which will ensure the preservation and comprehensive museification of unique natural objects.