bluuebunny/crossref_metadata_2025 huggingface dataset:
Biventricular Hypertrophic Cardiomyopathy in a Child with LEOPARD Syndrome: a Case Report
Authors: Blesneac Cristina , Șuteu Carmen-Corina , Bănescu Claudia , Benedek Theodora , Benedek Imre , Togănel Rodica
Published: March 2018

Background: LEOPARD syndrome is a complex dysmorphogenetic disorder of inconstant penetrance and various morphologic expressions. The syndrome is an autosomal dominant disease that features multiple lentigines, electrocardiographic changes, eye hypertelorism, pulmonary valve stenosis or hypertrophic cardiomyopathy, genital malformations, and a delayed constitutional growth hearing loss, which can be associated with rapidly progressive severe biventricular obstructive hypertrophic cardiomyopathy. No epidemiologic data are available on the real incidence of LEOPARD syndrome; however, this seems to be a rare disease, being often underdiagnosed, as many of its features are mild.

Case presentation: We report the case of a 10-year-old female pediatric patient, diagnosed with obstructive hypertrophic cardiomyopathy at the age of 3 months, and recently diagnosed with LEOPARD syndrome. The patient first presented for a cardiologic examination at the age of 3 months, due to a murmur. She presented failure to thrive and psychomotor retardation, and was diagnosed with biventricular obstructive hypertrophic cardiomyopathy for which she had received high-dose beta-blocker therapy. At the age of 7 years she underwent a biventricular myectomy for relief of outflow tract obstruction, completed with another myectomy after 2 years due to progressive increase of pressure gradient in the left ventricular outflow tract. Prior to the second surgical intervention, multiple lentigines appeared on her skin, and genetic testing revealed the presence of LEOPARD syndrome.

Conclusion: LEOPARD syndrome is a rare disease, which can be very difficult to diagnose, especially based on features other than lentigines. Cardiac involvement in LEOPARD syndrome can be progressive and requires multiple medical and surgical interventions.
First results of the Nordic and Baltic GNSS Analysis Centre
Authors: Lahtinen Sonja , Pasi Häkli , Jivall Lotti , Kempe Christina , Kollo Karin , Kosenko Ksenija , Pihlak Priit , Prizginiene Dalia , Tangen Oddvar , Weber Mette , Paršeliūnas Eimuntas , Baniulis Rimvydas , Galinauskas Karolis
Published: March 2018

The Nordic Geodetic Commission (NKG) has launched a joint NKG GNSS Analysis Centre that aims to routinely produce high qualityGNSS solutions for the common needs of the NKG and the Nordic and Baltic countries. A consistent and densified velocity field is needed for the constraining of the gla-cial isostatic adjustment (GIA) modelling that is a key component of maintaining the national reference frame realisations in the area. We described the methods of the NKG GNSS Analysis Centre including the defined processing setup for the local analysis centres (LAC) and for the combination centres.We analysed the results of the first 2.5 years (2014.5-2016). The results showed that different subnets were consistent with the combined solution within 1-2 mm level. We observed the so called network effect affecting our reference frame alignment. However, the accuracy of the reference frame alignment was on a few millimetre level in the area of the main interest (Nordic and Baltic Countries). TheNKGGNSS AC was declared fully operational in April 2017.
On the security of the Courtois-Finiasz-Sendrier signature
Authors: Morozov Kirill , Roy Partha Sarathi , Steinwandt Rainer , Xu Rui
Published: March 2018

We prove that a variant of the Courtois-Finiasz-Sendrier signature is strongly existentially unforgeable under chosen message attack in the random oracle model, assuming hardness of the Permuted Goppa Syndrome Decoding Problem (also known as the Niederreiter problem). In addition, we explicitly show that security against key substitution attacks can be arranged by a standard technique of Menezes and Smart, hashing the public key.
On the structure vector field of a real hypersurface in complex quadric
Authors: Dios Pérez Juan de
Published: March 2018

From the notion of Jacobi type vector fields for a real hypersurface in complex quadric Qm
we prove that if the structure vector field is of Jacobi type it is Killing when the real hypersurface is either Hopf or compact. In such cases we classify real hypersurfaces whose structure vector field is of Jacobi type.
Effect of pulsed magnetron sputtering process for the deposition of thin layers of nickel and nickel oxide
Authors: Posadowski Witold , Wiatrowski Artur , Kapka Grzegorz
Published: March 2018

Magnetron sputtered nickel and nickel oxide films have been studied for various applications. We may find, among others, these films in electrochromic display devices, in resistive type gas sensors, as metal electrodes in electronic devices, in solar thermal absorbers. Pure nickel films deposited using PVD technique possess good corrosion and wear resistant properties. Magnetron sputtering has several advantages in film deposition (in comparison to other methods) such as relatively low heating temperature of the deposited substrate during sputtering process, high energy of sputtered atoms (about 10 eV) at the substrate, which influences positively the films adhesion. From application point of view, the most valuable feature of these films is the possibility of scaling target dimensions, which makes feasible the deposition on a several square meter surfaces. The improvement of magnetron sputtering devices design may influence positively the optimization of the deposition technology and its efficiency. The thin nickel and nickel oxide films were prepared by pulsed magnetron sputtering using original type WMK magnetron device. Ni (99.9 %) has been used as a sputtering target of 100 mm in diameter and different thicknesses (3 mm, 5 mm, and 6 mm). The distance between the substrate and target was the same in all experiments and equal to 120 mm. Argon and oxygen gases were introduced during the reactive process through needle gas valves at a total pressure of 0.4 Pa. The sputtering power, sputtering pressure and oxygen partial pressure have been used as technological knobs for deposition processes. The helpful tool for controlling the pulsed magnetron sputtering process was the original parameter of supply (so called circulating power). Results from our experiments showed that the deposition of Ni films is possible even from targets of 6 mm thickness. Deposition rate increased proportionally with the sputtering power. The aim of this work is to use the acquired expertise to develop an efficient technology of thin nickel oxide layers for electrochromic systems.
Thin SixNyCz films deposited from hexamethyldisilazane by RF PECVD technique for optical filter applications
Authors: Oleśko Katarzyna , Szymanowski Hieronim , Gazicki-Lipman Maciej , Balcerzak Jacek , Ski Witold Szymań , Pawlak Wojciech , Sobczyk-Guzenda Anna
Published: March 2018

This work initiates a series of reports aimed at a construction of rugate optical filters based on silicon rich materials of alternating gradients of refractive index n with the help of plasma enhanced chemical vapor deposition (PECVD) technique, The idea is to start deposition of high refractive index SixNy type of material using hexamethyldisilazane (HMDSN) vapor and nitrogen rich atmosphere, and then to gradually replace nitrogen with oxygen in that atmosphere in order to lower n down to a minimum characteristic of SixOy type of material. A return to initial gas composition should increase the index back to its maximum. In the present work, thin SixNyCz films were synthesized from a mixture of HMDSN vapor with gaseous NH3 and N2. The effect of NH3/N2 ratio on the coating morphology, its elemental composition, chemical bonding and optical properties was studied using scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, ultra-violet absorption spectroscopy and variable angle spectroscopic ellipsometry. The results show that films of the highest index of refraction and the lowest extinction coefficient have been deposited from the gas mixture containing 90 % of ammonia. These coatings are also characterized by the lowest carbon and the highest nitrogen contents.
Das Verbot der deutschen Luftfahrtindustrie und die Erfindung ihrer Geschichte, 1945 bis 1953
Authors: Budrass Lutz
Published: March 2018

The ban on German aviation and the creation/fabrication of its history The article traces the origins of two central features of the historiography of the German aircraft industry: while its contribution to technical progress by the end of World War II tends to be grossly exaggerated – particularly in the case of the so-called Wunderwaffen, the jet fighters of Messerschmitt and Heinkel – its industrial basis und its role in the German war economy are played down to an impression that, until 1945, the industry consisted of tiny workshops of mere handicraft character. It is shown that this narrative was carefully constructed between 1945 and 1953, highlighted by memoirs of former military leaders of the Luftwaffe like Adolf Galland and Werner Baumbach, but predominantely through the memoirs of Ernst Heinkel, the leading industrialist during the Nazi period. These memioirs appeared at a time when it seemed unlikely – due to a total ban on German aviation under the Allied occupation – that a German aircraft industry would ever rise again. By exaggerating the German technological lead in 1945 they eased the idea that the industry was outdated when the chances grew for its return to the international market in 1953. Meanwhile, the outright denial of the size and importance of the industry during the war indirectly provided a chance to gloss over the participation of the industrialists in the Nazi crimes, highlighted by the use of concentration camp inmates and slave labourers who formed the bulk of the workforce in the production of the Wunderwaffen.
Haloperidol ameliorates androgen-induced behavioral deficits in developing male rats
Authors: Qi Chunxiao , Ji Xiaoming , Zhang Guoliang , Kang Yunxiao , Huang Yuanxiang , Cui Rui , Li Shuangcheng , Cui Huixian , Shi Geming
Published: March 2018

The purpose of present study was to infer the potential effects of testosterone increase in some male-based childhood-onset neuropsychiatric disorders, such as Tourette syndrome. Thus, the influence of early postnatal androgen exposure upon the neurobehaviors and its possible neural basis were investigated in the study. Male pup rats received consecutive 14-day testosterone propionate (TP) subcutaneous injection from postnatal day (PND) 7. The TP treatment produced the hyperactive motor behavior and grooming behavior as well as the increased levels of dopamine, tyrosine hydroxylase and dopamine transporter in the mesodopaminergic system and the elevated levels of serotonin in the nucleus accumbens, without affecting the levels of glutamate, γ-aminobutyric acid, norepinephrine and histamine in the caudate putamen and nucleus accumbens of PND21 and PND49 rats. Dopamine D2 receptor antagonist haloperidol was administered to the early postnatal TP-exposed PND21 and PND49 male rats 30 min prior to open field test. Haloperidol significantly ameliorated the motor behavioral and grooming behavioral defects induced by early postnatal TP exposure. The results demonstrated that early postnatal androgen exposure significantly disturbed the brain activity of developing male rats via enhancing the mesodopaminergic activity. It was suggested that abnormal increments of testosterone levels during the early postnatal development might be a potential risk factor for the incidence of some male-based childhood-onset neuropsychiatric disorders by affecting the mesodopaminergic system.
Inter-replicon Gene Flow Contributes to Transcriptional Integration in the Sinorhizobium meliloti Multipartite Genome
Authors: diCenzo George C , Wellappili Deelaka , Golding G Brian , Finan Turlough M
Published: March 2018

Integration of newly acquired genes into existing regulatory networks is necessary for successful horizontal gene transfer (HGT). Ten percent of bacterial species contain at least two DNA replicons over 300 kilobases in size, with the secondary replicons derived predominately through HGT. The Sinorhizobium meliloti genome is split between a 3.7 Mb chromosome, a 1.7 Mb chromid consisting largely of genes acquired through ancient HGT, and a 1.4 Mb megaplasmid consisting primarily of recently acquired genes. Here, RNA-sequencing is used to examine the transcriptional consequences of massive, synthetic genome reduction produced through the removal of the megaplasmid and/or the chromid. Removal of the pSymA megaplasmid influenced the transcription of only six genes. In contrast, removal of the chromid influenced expression of ∼8% of chromosomal genes and ∼4% of megaplasmid genes. This was mediated in part by the loss of the ETR DNA region whose presence on pSymB is due to a translocation from the chromosome. No obvious functional bias among the up-regulated genes was detected, although genes with putative homologs on the chromid were enriched. Down-regulated genes were enriched in motility and sensory transduction pathways. Four transcripts were examined further, and in each case the transcriptional change could be traced to loss of specific pSymB regions. In particularly, a chromosomal transporter was induced due to deletion of bdhA likely mediated through 3-hydroxybutyrate accumulation. These data provide new insights into the evolution of the multipartite bacterial genome, and more generally into the integration of horizontally acquired genes into the transcriptome.
Colombia y la transición energética
Authors: Corredor Germán
Published: March 2018

En el siglo XX y hasta el día de hoy el mundo utilizó como fuentes energéticas primarias (de manera prioritaria) los denominados combustibles fósiles, a saber, el petróleo, el carbón y el gas natural. Sin embargo, los efectos sobre el ambiente que han dado lugar al cambio climático han generado una tendencia cada vez más creciente a reemplazar estas energías por fuentes más limpias como la eólica, la solar o la geotérmica. Aún se plantean acciones más radicales como reducir el consumo de energía de forma drástica para evitar una catástrofe global de proporciones inimaginables. Este proceso se ha denominado “la transición energética”, que sin lugar a dudas se viene desarrollando en mayor o menor medida en casi todos los países del así llamado “primer mundo”. En este artículo se analiza la situación de la matriz energética colombiana y las políticas del país de cara a este proceso de transición hacia energías limpias.
Középkori sírkőtöredék Kácsról
Authors: Lővei Pál
Published: March 2018

Among the ruins of the medieval Benedictine monastery of Kács an inscribed tombstone was found in 1882. Together with other stone carvings, it went into canon of Eger Gyula Bartalos’s possession, then from his estate into the lapidary of the Liceum of Eger, and finally to the Castle Museum of Eger.
Grafikatörténeti érdekességek manierista Krisztus-típusok fényében
Authors: Szilárdfy Zoltán
Published: March 2018

St John of God is the patron saint of booksellers and bookbinders. An engraving by Joseph Anton Schmidt of Augsburg depicts him, still in civilian clothes, in a baroque printing office of the engraver’s time, around 1770. Johann Andreas Pfeffel jr. made an engraved portrait of his father with a German text of 8 lines under it. My collection has two engravings from around 1670 showing engraving workshops.

Hereafter I am going to list types of Christ. In Johann Andreas Pfeffel sr.’s composition the triumphant Saviour is standing on the instruments of Passion on top of Golgotha, with the flag of Easter in his right hand. His favourite disciple is holding to a rope lowered by the Heavenly Father, his feet treading on the column of the flagellation. The meaning of the allegorical picture is illumined by a quotation from St John’s Gospel (6,44). The Lord Triumphing over Death is reminiscent of a painting by Giovanni Battista Tinti: the blood flowing from Jesus’s heart is gathered by an angel in a cup. Christ’s foot is treading on a skull, he is holding his cross with the wreath of thorns. The mannerist painter of Parma drew inspiration from Michelangelo’s Risen Christ in Rome’s S. Maria sopra Minerva. In a book illustration Pfeffel depicts the blood and water from the side of the transfigured Saviour as the material of the Eucharist, adoring angels gathering it in a chalice and a pitcher.

In Buda’s Víziváros district, on the first side altar on the right in the former Franciscan church (later belonging to the sisters of St Elizabeth) a painted version of the votive statue of Vir Dolorum in Matrei in Tyrol, of which János Fülöp Binder made an engraving, was venerated.

Two monumental works by Michelangelo Buonarroti convey the mystery of Easter. The statue of Jesus in BasBassano Romano was made by Michelangelo earlier (1514- 16) and can thus be taken as precedent to the sculpture of a similar theme in S. Maria sopra Minerva (1521). The dominant attribute is the cross. In the earlier sculpture, in addition to the ropes, sponge and loincloth, the robe of mockery is dropped by Christ’s left hand onto the column of his flogging, which also serves as support.

There is a short red jasper column in the middle of a recess opening from the St Zeno chapel in Rome’s Basilica di S Prassede. Cardinal Giovanni Colonna, the commander of the papal army of the fifth crusade (1219) brought it home from the Holy Land and set it up in 1223. It is allegedly the column of Christ’s flagellation. The Greek emperor Alexios I Komnenos listed the relics kept in Constantinople in 1092: he already mentioned the purple robe and the reed. A register of 1200 includes the sponge, the purple chlamys and the reed in the sanctuary of Hagia Sophia. After the transfer of the relics to Rome, the reed with the sponge could be found in the reliquary of the Sancta Sanctorum in the Lateran. The Lord’s loincloth was preserved in the cathedral of Aachen visited by pilgrims for plenary indulgence as late as the 16th century.
A kastély részei, berendezése és tartozékai a 16–17. századi Dunántúlon
Authors: Koppány Tibor
Published: March 2018

Several country houses built in Transdanubia (western Hungary) in the early modern age, in the 16-17th centuries are still extant, though most are massively rebuilt. The original state of a mansion can be learnt from archeological investigations, old depictions as well as written sources, particularly inventories. Many of these from the leading aristocratic family archives have been studied by researchers, but the majority are still unpublished. They do not suffice for the perfect reconstruction of the original state of the layout (topography) of the buildings, but their high number allow for statistical inferences to be made about certain general characteristics of usage, furnishing, interrelation of building sections. Constant items in the inventories are: the gate, gatehouse, courtyard, “palace”, the latter including the audience chamber, rooms, staircase, etc. Only the inventories provide a glimpse of the one-time furnishing: lots of tapestries, pictures, carpets, pieces of furniture made these mansions liveable. The sources touch on the gardens in quite some detail, too. This comprehensive paper is closely tied to the author’s earlier published volumes inventorying the country houses (with source publications), and summarizes several decades of research, practical experience and archival investigations within the scope of monument protection.
Kortársak a Galimberti házaspár művészetéről
Authors: Tímár Árpád
Published: March 2018

During their tragically short artistic careers Sándor Galimberti (1883–1915) and his wife Valéria Dénes (1877–1915) roused the interest of the critics three times. After a stay in Paris for several years, they staged their first exhibition of their collected works in Budapest in January 1914, which elicited vivid, mostly appreciative reviews. The critics claimed they were representing the most up-to-date Paris trends in Hungary. Hardly a year later, several obituaries made their careers and artistic works known after their tragic death. In 1918 the group of activists organized by Lajos Kassák presented the work of the couple acknowledged as their forerunners in the exhibiting room of MA, which also drew wide and positive press coverage.
Leletek Székesfehérvár középkori Szent Péter-plébániatemplomából
Authors: Reich Szabina , Kulcsár Mihály , Lángi József , Bartos György , Lővei Pál
Published: March 2018

Archaeological excavations in 2014–2016 carried on outside the western front and in the western towers of St Stephen’s cathedral of Székesfehérvár built in the 18th century in baroque style using the remains of the mediaeval parish church as well as wall research related to the restoration of the western facade of the church have brought to light several important finds for art history. They include mediaeval tombstones, tomb lid fragments and under the floor of the northern tower details of the base strip of a gothic wall painting. The most important find is a tomb lid surviving in its entirety but crushed to pieces by the weight of the collapsing vault. The unfinished — uninscribed — stone slab placed over the grave was carved of red marble around 1415–1420, but the coat of arms represented on it cannot be associated with any person or family so far. It appears to be connected to the beginnings of the Buda workshop — and this connection particularly enhances its value — whose sculptor-entrepreneur owner was nicknamed by research, out of necessity, the Master of the Stibor tombs.
Adalékok Újlak egyházi kincseinek és privilégiumának sorsához (1528)
Authors: Gulyás Borbála
Published: March 2018

The significant medieval town Újlak (today: Ilok, Croatia) located in the southern part of the Kingdom of Hungary was successfully besieged by the Ottomans in 1526. However, its several church treasures (paraments, liturgical objects) together with the richly decorated borough charter of the town (1525–26, today in Vienna) were transferred to Nagyszombat (Trnava, Slovakia) and later to Vienna. The paper examines the transfer of the various objects based on inventories and letters of 1528.
A keszthelyi Festetics-kastély építéstörténete az új kutatások tükrében
Authors: Németh Nóra , Virág Zsolt
Published: March 2018

As recent researches in archives, map libraries and the physical building have revealed, the Festetics palace of Keszthely was built in three main periods, and between the second and the third phases a major reconstruction can also be identified. The approximately rectangular eastern main wing was built during the proprietorship of Kristóf Festetics in 1745 and 1750 in baroque style. It is not yet known who designed this phase of construction, but the finishing touches were done with manorial master builder Kristóf Hoffstedter playing an important role. Though the surviving plans suggest that on several occasions the idea of extending the building to a U shape was considered, an asymmetrical L-shaped southern wing was eventually built during Count György (I) Festetics between 1792 and 1804 with its outward-turning section as the library wing. The neo-classical late baroque style addition was based on the logic of Kristóf Hoffstedter’s earlier plans. In 1866 Tasziló (I) Festetics had the residence modified in historicist style, after plans most probably made by the Viennese architect Friedrich Flohr who also supervised the construction. The current form of the palace emerged during the proprietorship of Count (later Prince) Tasziló (II) Festetics in 1883-87 under the aegis of historicism, in revived baroque and rococo styles. That was when the northern L-shaped wing was added, to complete one of the largest aristocratic Hungarian mansions. The plans of reconstruction and extension were made by the Viennese architect Victor Rumpelmayer under the guidance of the owner. Nine plan drawings in ink survive in the archive. After the death of the architect in 1885 construction went on under the supervision of Viennese architects and building contractors Gustav Haas and Maximilian Paschkis. The building contractor was the firm of Oskar Laske. For the interior design and the decoration of the suites and central spaces the Viennese Portois and Fix company was contracted.
Hogyan indult a magyar műemléki topográfia?
Authors: Entz Géza Antal
Published: March 2018

The inventorying of historical monuments [Kunsttopographie / Denkmaltopographie] is the first major collective and joint undertaking of Hungarian art history and monument protection. Within this project, monuments in four and a half of Hungary’s 19 counties and the Buda districts of Budapest were processed and published in 12 volumes between 1953 and 1987, by adopting the conception of the Austrian inventory of monuments (Österreichische Kunsttopographie) published from 1907. Sufficient conditions for systematic work for this fundamentally important project for both art history and monument conservation were only given in the period specified above. In connection with the radical institutional changes brought about by the building out of a Soviet-type state administration from 1948, the paper reconstructs the series of events which made it possible – based on the excellent professional legacy and human resource and thanks to the keen judgement of some specialists in key positions – that this grand project could be launched with great zeal and survived – at a decelerating pace but at unchanged professional level – for three decades to come. The professional contents of the program is illumined by three documents and a conference paper read in November 1950 on the conception of the inventory of Hungarian historical monuments, which are enclosed in the supplement. The scholar to present the project was the art historian Dezső Dercsényi, who became the supreme professional guide of Hungarian monument protection until his retirement by virtue of his professional competence and exceptional diplomatic skills. The inventory was being elaborated under the aegis of the Hungarian Academy of Sciences reorganized upon the Soviet model in late 1949. Against this background did that unique intellectual constellation evolve in which the cooperation of the Marxist philosopher György Lukács, who had returned from emigration in Moscow in 1945 and played an active role in the Sovietization of culture including scholarship; of the Christian philosopher Lajos Fülep, a youthful intellectual comrade of Lukács in internal exile in this period whom Lukács asked to head the art historical community; of Dercsényi and the excellent specialists promoted the cause of the registration of Hungarian historical monuments to success. In this way the major break in history did not entail the interruption of so-far achieved results and up-to-date strategic endeavours in the studied area of culture and science but resulted in an unprecedented consolidation of the positions of Hungarian monument protection and art history at an elevated level.
Identification key and pictures of the Hypostomus Lacépède, 1803 (Siluriformes, Loricariidae) from the rio Ivaí, upper rio Paraná basin
Authors: Dias Angelica C. , Zawadzki Cláudio H.
Published: March 2018

The rio Ivaí flows through the left margin of the upper rio Paraná basin with 798 km of extension, being one of its largest tributaries. In this study, we analyzed 586 specimens of Hypostomus Lacépède, 1803 from the rio Ivaí basin deposited in the Coleção de Peixes do Núcleo de Pesquisas em Limnologia, Ictiologia e Aquicultura da Universidade Estadual de Maringá (NUP) and Coleção Ictiológica do Grupo de Pesquisas em Limnologia e Recursos Pesqueiros (CIG). Herein, 14 species of Hypostomus were recorded from the rio Ivaí basin (10 already described and 4 possible new). The most representative species was H. ancistroides, corresponding to 23.5% of all the specimens, followed by Hypostomus sp. 3, with 15.2%, and Hypostomus sp. 2, with 13.8%. Considering Hypostomus, this study suggests that the rio Ivaí has high species richness compared with adjacent basins, such as rio Paranapanema, rio Tibagi, rio Piquiri and rio Iguaçu. Knowing the difficulties founded by many ichthyologists and researchers in identifying species within this genus, we also present here an identification key for its species present in the rio Ivaí basin.
Phenology of the production of flowers and fruits of wild and hybrid species of the genus Passiflora
Authors: Esashika Danilo Akio de Sousa , Faleiro Fábio Gelape , Junqueira Nilton Tadeu Vilela
Published: March 2018

Abstract Wild species of passion fruit have characteristics that could be used in the passiflora culture, among them the production of fruits in the off-season of the sour passion fruit. The objective of this work was to evaluate the phenology of flowers and fruits production in wild species cultivated in the Brazilian Savanna Central Region. For each access, a 1-meter-long strip (2 m2) was evaluated for the presence of flowers and fruits from January 2015 to December 2016. The hybrid and wild species of passiflora that produce floral buds, flowers and fruits during the off-season of passion fruit sour include: BRS Céu do Cerrado (P. incarnata x P. edulis), P. alata Dryand, P. bahiensis Klotzsch, P. coccinea Aubl., P. maliformis L., P. quadriglandulosa Rodschied, P. auriculataKunth, P. decaisneana G. Nicholson, P. sidifolia M. Roem., P. suberosa L., P. tholozanii Sacco, P. quadrangularis x P. alata. It was also verified the presence of species and hybrids with high ornamental potential due to the beauty of their flowers and their production during the whole year, such as: P. suberosa L., P. tholozanii Sacco, P. coccinea x P. setacea, P. coccinea x P. quadrifaria. These species and hybrids have high potential for passiflora breeding programs as a source of genes of interest.
CINCO TEMAS CENTRAIS NA CONSTITUIÇÃO DA RELAÇÃO EDUCAÇÃO-TRABALHO NO BRASIL
Authors: Marchesan Eduardo Caliendo
Published: March 2018

RESUMO: Apresentando cinco temas centrais no debate sobre a relação educação-trabalho no Brasil, este artigo dá relevo ao fundamento sobre o qual eles estão assentados. Tais temas - a teoria do capital humano; a escola como reprodução; a dualidade estrutural da educação; a perspectiva marxista sobre o papel do trabalho na escola; e a crise do trabalho - ganham evidência a partir da década de 1970 fundados numa nova possibilidade que emerge no discurso educacional: o mundo do trabalho pode, ou deve, impor demandas à escola nacional, alterando sua organização e suas práticas. A tese defendida circunscreve o objeto partilhado por este campo e diz que a possibilidade mencionada é precisamente aquilo a que se dá o nome de educação para o trabalho.
Development and characterization of light yoghurt elaborated with Bifidobacterium animalis subsp. Lactis Bb-12 and fructooligosaccharides
Authors: Witschinski Fabiele , Demartini Débora , Kilian Josiane , Dallago Rogério Marcos , Rosa Clarissa Dalla , Cansian Rogério Luis , Valduga Eunice , Steffens Juliana
Published: March 2018

ABSTRACT: This study aimed to evaluate the effects of adding probiotic culture (Bifidobacterium animalis subsp. Lactis Bb-12) and prebiotics (fructooligosaccharide - FOS) to yoghurt formulations stored at 4°C for 28 days, using an experimental design (independent variables: (0-3% of FOS and probiotic starter cultures 0-3%). The pH, acidity, fat, syneresis, protein, ºBrix, sugars, FOS and probiotic bacteria count were analyzed. The probiotic- and prebiotic-added yoghurt formulations showed lower acidity, syneresis and glucose than the control yoghurt and compared to formulations containing probiotic and prebiotic separately. The 3% probiotic and prebiotic formulation showed a lower loss of concentration of FOS, and after 28 days presented 1.5g of FOS per 100g (0.3% kestose, 0.7% nystose, 0.5% fructosyl-nystose). Furthermore, the addition of prebiotics exerted a protective effect on probiotic bacteria, enhancing their survival.
Could mesenchymal stem cell therapy help in the treatment of muscle damage caused by Bothrops alternatus venom?
Authors: Telles Thalita da Costa , Botelho Ana Flávia Machado , Miranda Ana Luisa Soares de , Soto-Blanco Benito , Serakides Rogéria , Ocarino Natália de Melo , Melo Marília Martins
Published: March 2018

ABSTRACT: The aim of this study was to evaluate the use of mesenchymal stem cells (MSC) in the treatment of myonecrosis induced by Bothrops alternatus venom in rats. Seventy-five male adult Wistar rats were divided into three experimental groups. G1 and G2 were injected in the gastrocnemius muscle with 120μg of B. alternatus venom, while G3 received 200μL of PBS only. Three days after the venom injection, 12 rats from G1 were treated with 5.0 x 106 MSC in PBS, whereas G2 and G3 rats received PBS. Every three days, blood and muscle samples of five animals from each group were taken for serum biochemical and pathological analyses. Histological examinations showed more intense muscle lesions following MSC treatment, characterized by disorganization and loss of muscle fibers, with focal necrosis and inflammatory infiltration by mononuclear cells. In conclusion, the use of MSC for the treatment of local damage caused by inoculation of B. alternatus venom impaired muscle regeneration and interfered in the healing process.
EFEITO DE DUAS TÉCNICAS DE BANHO DE IMERSÃO NA TEMPERATURA AXILAR DE RECÉM-NASCIDOS PRÉ-TERMOS: ESTUDO PILOTO
Authors: Freitas Patrícia de , Munhoz Maitê Martini Benedecte , Costa Priscila , Kimura Amélia Fumiko
Published: March 2018

RESUMO Objetivo: comparar as temperaturas axilares pós-banho de imersão de recém-nascidos pré-termos envoltos e não em lençol. Método: estudo piloto, do tipo ensaio clínico cruzado; participaram 15 neonatos pré-termos, clinicamente estáveis internados na unidade neonatal, que receberam os dois tipos de banho em intervalo, entre 24 e 48 horas, seguindo uma lista de randomização da sequência dos banhos. O teste t-Student pareado e o valor p ≤ 0,05 e IC 95% foram adotados. Resultados: as temperaturas do ambiente pré-banhos e da água do banho e axilar apresentaram homogeneidade entre os grupos. As médias da temperatura axilar dos recém-nascidos no 10°e 20° minutos após os banhos foram similares. Independente da técnica, os recém-nascidos apresentaram leve hipotermia pós-banho. Conclusão: estudos sobre o efeito do banho de imersão nos parâmetros fisiológicos e comportamentais são necessários para avaliar a segurança do procedimento.
Real-time traffic event detection using Twitter data
Authors: Jones Angelica Salas , Georgakis Panagiotis , Petalas Yannis , Suresh Renukappa
Published: March 2018

Incident detection is an important component of intelligent transport systems and plays a key role in urban traffic management and provision of traveller information services. Due to its importance, a wide number of researchers have developed different algorithms for real-time incident detection. However, the main limitation of existing techniques is that they do not work well in conditions where random factors could influence traffic flows. Twitter is a valuable source of information as its users post events as they happen or shortly after. Therefore, Twitter data have been used to predict a wide variety of real-time outcomes. This paper aims to present a methodology for a real-time traffic event detection using Twitter. Tweets are obtained through the Twitter streaming application programming interface in real time with a geolocation filter. Then, the author used natural language processing techniques to process the tweets before they are fed into a text classification algorithm that identifies if it is traffic related or not. The authors implemented their methodology in the West Midlands region in the UK and obtained an overall accuracy of 92·86%.
RESEARCH OF TISSUE ACTIVITY OF METALLOPROTEINASES AT VARIOUS FORMS OF AN ADENOMYOSIS
Authors: Levakov S A , Korobeinikov A P , Demura T A
Published: March 2018

Enzymatic activity matrix metalloproteinase's 2 and 9 in an operational material (the amputated uteruses) concerning diffusive and nodal forms of an adenomyosis at women in the late genesial period was studied. Research was spent with use of an immunohistochemical method on paraffinic sections. Results of immunohistochemical reaction were estimated by a semiquantitative method in points by quantity of positively painted cells. Activation and expression intensifying gelatinase ММР2 and ММР9 has been shown at diffusive and nodal forms of an adenomyosis and their various degrees of a lesion of a myometrium. Also it has been shown, that in a stroma and myometriums at diffusive and nodal forms of an adenomyosis the expression gelatinanases ММР9 was more intensively.
MYOMECTOMY AT CESAREAN SECTION
Authors: Torubarov S F , Levakov S A , Korobeynikov A P
Published: March 2018

The article summarizes current opinion and personal experience of authors of organ therapy in pregnant women with major sites of uterine fibroids. Features of myomectomy during cesarean section are presented in 14 patients.
PROPHILAXIS ANEMIA IN PREGNANCY
Authors: Levakov S A , Kozhurina E V , Kedrova A G , Stuklov N I , Torubarov S F
Published: March 2018

Pregnancy anemia is one of the important public health problems not only in Russian but also in another countries. Indeed, it is a known risk factor for many maternal and fetal complications. Anemia put to the worse many risk factors: young age, obstetrical factors (history of previous preterm or small- for gestational-age deliveries, plurality of pregnancy multiple or singleton); behavioral factors (smoking or tobacco usage, alcohol usage); medical conditions (diabetes, renal or cardio-respiratory diseases, chronic hypertension). If all pregnant women receive routine iron and folic acid, it is possible to prevent nutritional anemia. Therefore, 50 -100milligrams elemental iron and 500-1000 micrograms of folic acid daily for 100 days must be taken into national nutritional anaemia prophylaxis program to all pregnant women.
CASE OF SUCCESSFUL TREATMENT OF PULMONARY EMBOLISM WITH INVASIVE METHODS
Authors: Alekseeva Yu M , Potievskaya V I , Lebedev D P , Agagulyan E V
Published: March 2018

This research is devoted to analyzing of the case of pulmonary embolism in a young woman with deep vein thrombosis taking oral contraceptives and successfully treated by surgical methods. Pulmonary angiography performed in patient L. allowed to confirm the diagnosis ofpulmonary embolism and reveal the localization of the thrombus. The treatment included selective thrombolysis by actilyse through catheter in the pulmonary artery. The treatment was not only non-invasive but included surgical intervention. Using of invasive methods, thrombolysis and anticoagulant medication allowed to stabilize the condition of the patient and prevent development of right ventricular failure.
COMPARATIVE EFFICACY OF COMBINATION CONTACT AND TRANSURETHRAL PERCUTANEOUS LITHOTRIPSY WITH REMOTE LITHOTRIPSY IN CORALLOID NEPHROLITHIASIS TREATMENT
Authors: Perepechai V A , Zozulya A V , Skorikov I I , Dimitriadi S N , Gornostaev V N
Published: March 2018

A retrospective analysis of results of percutaneous nephrolithotripsy (PNLT) for corallike nephrolithiasis in lithotripter "Swiss LithoClast ® Master" and transurethral nephrolithotripsy (TUNLT). In the period 20072010 167 PNLT and 11 TUNLT were performed. Complete elimination at PNLL was achieved in 83.2% of patients, residual concretions – in 16,8% of cases, with complete elimination TUNLT – 36,4%, residual concretions – 63,6%. In 3% of patients needed for the complete elimination of the implementation of additional percutaneous accesses, while 12.6% of the patients was necessary to repeat PNLT. Complications from PNLT + DLT developed in 30,2% of cases, and when the TUNLT + DLT – in 18,2%. Percutaneous technology in comparison to open surgery with corallike nephrolithiasis can significantly shorten the postoperative rehabilitation period and be choice method of the treatment due to its high efficiency and less traumatic.
MORPHOHYSTOMETRICAL INDICATORS OF STROMAL AND PARENCHYMAL RELATIONSHIPS AT ORGANISM AGING
Authors: Zabozlaev F G , Sorokina A V
Published: March 2018

The clinicomorphological analysis with using the histostereometric method of research of myocardium, liver and kidneys, taken from the autopsies of 160 died patients from the period 20092010 was performed in the age aspect. Significant direct changes of the specific volume of highly specialized myocardium and liver cellular structures and stromal component were revealed at the organism aging. The specific volume of a bloodstream had veracious multidirectional action vector – in myocardium and liver. The identification of relative indicator of histostereometrical indicator dynamics in myocardium and liver allows to use it for updating the assessment of the stromal and parenchymal relationships at organism aging.
MODERN MATERIALS APPLICATION IN SURGERY OF INGUINAL HERNIAS
Authors: Protasov A V , Shuhtin N Ju , Pokruchin N A , Panichenko V F , Rogatchyov M V
Published: March 2018

The authors presented the perspectives of optimizing surgical treatment inguinal hernias by using nonsutured mesh implants (based on polypropylene and polylactic acid).
FORGOTTEN FOREIGN BODY IN ABDOMINAL OPERATIONS: RANDOM OR INEVITABLE?
Authors: Ivanov Yu Viktorovich
Published: March 2018

The article analyzes the reasons for the abandonment of abdominal foreign bodies during surgery, offered a number of organizational measures aimed for reducing the risk of such cases. Gives a clinical example of a long stay of a foreign body in the zone of operations simulating the neoplastic process.
VITAMINS AND MINERALS AS AN ALTERNATIVES TO REDUCE THE SYMPTOMS OF MENOPAUSE AFTER OOPHORECTOMY IN WOMEN OVER 45 YEARS OLD
Authors: Levakov S A , Kedrova A G , Vanke N S , Kozhurina E V , Kaganovskaya L M
Published: March 2018

Menopause is an unavoidable change that every woman will experience, assuming she reaches middle age and beyond. An early menopause can be related to the surgical removal of the uterus and/or both ovaries. The article presents the main evaluation of the clinical severity and characteristics of the menopausal syndrome after oophorectomy. Our experience has shown that vitamins and minerals, as an alternative to hormone replacement therapy reduces the severity of menopause symptoms. They play a central role in many body processes for menopausal women. Studies have linked it to preventing heart disease, osteoporosis, diabetes, cancer and weight gain. If that seems like a lot of prevention in one little vitamin, it is. The problem, though, is that as many as half of adults are deficient in vitamines and minerals and are therefore their minimum dose is not benefiting. Therefore, initiation of therapy always requires high doses of vitamins and minerals.
THE FIRST EXPERIENCE OF SURGICAL TREATMENT OF CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION
Authors: Chupin A V , Averyanov A V , Chernjak B B , Kemezh Ju V , Sitnikov A V , Prokofeva N V , Kasjanova N Ju , Bubnov V A
Published: March 2018

The case report of successful pulmonary thromboendarterectomy in 34 years old patient, suffered of chronic thromboembolic pulmonary hypertension and severe respiratory failure during 9 years is described.
SIMULATION AS AN APPROACH TO STUDY SURGICAL PATHOLOGY IN WEIGHTLESSNESS
Authors: Panchenkov D N , Astakhov D A , Alikhanov R B , Baranov A V , Nechunaev A A
Published: March 2018

This paper considers the modeling methods of peritonitis and effects of microgravity. We provide information about the probability of disease development in long duration space flight.
SPINAL CORD NEUROSTIMULATION – NEW METHOD FOR THE TREATMENT OF PAIN AND SPASTIC SYNDROMES
Authors: Safin A V , Kuzovlev O P
Published: March 2018

The article is devoted to a new technique in neurosurgery – spinal cord neurostimulation. It has also focused on the patophysiology of pain and spastic syndromes. Surgical treatment of pain, spasti-city and stages of neurostimulation are also considered.
METHOD OF VIBRATION AND COMPRESSION ON THE CHEST IN COMPLEX THERAPY OF COPD EXACERBATIONS
Authors: Turusina T A , Averyanov A V , Sotnikova A G
Published: March 2018

The results of the dynamics of clinical symptoms, functional parameters, quality of life in patients with COPD exacerbation under vibration and compression effects on the chest with the apparatus for physiotherapy are presented.
THE CLINICAL CASE OF THE PREVALENCE OF DERMATOLOGICAL MANIFESTATIONS IN PATIENT WITH NONSPECIFIC ULCERATIVE COLITIS
Authors: Sokurenko S I , Borisova T V , Semendyaeva M E , Bakulina I F
Published: March 2018

The clinical case of the patient with prevalence of extraintestinal manifestations (dermatological) of nonspecific ulcerative colitis is discussed. The diagnostic of nonspecific ulcerative colitis with insignificant intestinal symptomatology is very difficult. A correct estimation of all symptoms is promoting the timely diagnostic. This is leads to early administration of appropriate therapy, and allows to get the remission of ulcerative colitis.
COMPETITIVE ABILITY OF RUSSIAN MEDICAL SCIENCE: CURRENT STATE, PROBLEMS AND PROSPECTS
Authors: Merkulov I A
Published: March 2018

The policy documents devoted to advancement of science in Russia for the period till 2020 set a national goal to raise the level of competitiveness of national universities, research centers and research teams up to the world level. To achieve this goal we need to acknowledge the necessity to adopt the universally recognized criteria for assessment of a scientist's performance and to main- tain the highest standards of the national education and research activities. This article presents the results of analysis of compliance of Russian research works with the world standards of quali- ty and effectiveness. The analysis is based on materials of the international conference "Science online: online resources for science and education" and publications in Internet.
STEM CELLS FOR THE THERAPY OF ISCHEMIC HEART DISEASE: ADVANCES AND PROSPECTS
Authors: Konoplyannikov M A , Kalsin V A , Averyanov A V
Published: March 2018

Ischemic heart disease (IHD) accelerates death of cardiomyocytes and leads to the onset of cardiac failure. Due to the application of stem cells, there exists a potential for the regeneration of a damaged myocardium. Here we present a brief review of the modern data on the application of different types of stem cells for the IHD therapy. We pay special attention to the type of stem cells which is most preferable for the clinical application, namely, to the mesenchymal stem cells (MSC), including their advantages, clinical trials, as well as the strategy for the MSC optimization in order to boost their regenerative potential.
CLINICAL ASPECTS OF TREATMENT OF PATIENTS WITH LONG-PERSISTENT FORMOF ATRIAL FIBRILLATION AND DECOMPENSATED CHRONIC HEART FAILURE, USING A METHODOF RADIOFREQUENCY CATHETER ABLATION AND CARDIAC RESYNCHRONIZATION THERAPY
Authors: Kocharyan A A , Zhelyakov E G , Guseynova R R , Konev A V , Ardashev A V
Published: March 2018

The article describes a clinical case of a 64-years patient with long-lasting persistent atrial fibrillation with the progressive course of chronic heart failure, which successfully treated with CRT setting and RFA of AFib. Dynamic observation of the patient during 12 months confirmed the success of combined treatment – absence of arrhythmia recurrences and decreasing of NYHA heart failure functional class.
ANTIDEPRESSANTS` EFFECTS ON TREATMENT RESULTS OF ACUTE BACK PAIN
Authors: Shirshova E V
Published: March 2018

We presented the results of clinical trial of the effectiveness of antidepressants in acute and chronic back pain. It is shown that in patients with anxiety, depressive symptoms and emotional factors as triggers of disease exacerbation, inclusion of antidepressants in the complex treatment of acute back pain greatly increases the efficiency and reduces the time of treatment