bluuebunny/crossref_metadata_2025 huggingface dataset:
On Farm Study on the Efficacy of Nutrient Management Treatments on Bt. Cotton
Authors: Puniya Manmohan , Choudhary L. R. , Bagri D. K.
Published: November 2024

A farmer’s participatory field experiment was conducted during two kharif seasons of 2020 and 2021 at farmers’ fields in Mokheri, Bhojka, Kalimali and Phalodivillages of Jodhpur district of Rajasthan on loamy fine to coarse and medium to low in fertility status. To test the OFT on Efficient use of foliar fertilization technology in Bt cotton cropdeeloped by the Junagadh Agriculture University, Gujarat.The study aimed to analyze the performance and adoption of improved new agriculture technology is a crucialaspects under innovation diffusion process and the most important forenhancing agriculture production at a faster rate. These aspect On Farm Trials technology is one of the most powerful tools for assessment and transfer of technology.The present study was find out the production enhancement and economics through On Farm Trials technology of Bt. cottonon farmers’ fields. The technology On Farm Trial recorded additional pooled yield over farmers’ practices under OFTs the seed cotton and stalkyieldsof Bt. cottonwas increased 14.70 and11.48percent over farmers’ practices. Adoption of improvedpackage of practices under OFTs in Bt. cotton cultivation recorded higher B:C ratio 2.19 as compared to farmers’ practices 1.96 and net returns under OFTs was Rs. 69,287 and farmers’ practicesRs 54,287 recorded. Improved technology (OFTs seed cotton and stalk yields was 19.5 and 23.3 q/ha as compared to farmers’ practices 17.0 and 20.9q/ha. Thus, it may be concluded thatuse of fertilizers as per recommendation with foliar spray of WSF 1 % NPK (19:19:19) at flowering, Boll formation and Boll development stages is effective and economical feasible practice in Bt. Cotton of farming community under irrigated conditon of Rajasthan.
Echoes of Colonialism and Identity Crisis: A Postcolonial Analysis of Hayao Miyazaki’s Spirited Away
Authors: Banerjee Poulami , Sahi Navreet
Published: November 2024

Spirited Away, a Japanese animated fantasy film written and directed by Hayao Miyazaki in 2001 brings to the audience a story of a young girl, Chihiro who along with her parents enter into the world of spirits. The film narrates a story of disruptive identity, language, and belonging of the protagonist, Chihiro and echoes themes of cultural displacement and colonization. This paper will analyze the film and the journey of the individuals into a colonized space, where conventional identities are suppressed within a dominated cultural landscape. This paper will delve into an argument where the film will be analyzed from the perspective of postcolonialism, where Chihiro’s experiences in the spirit world reflect the tussle of the colonized people dealing with distorted identities, language, and complicated notion of belonging. Chihiro’s arrival into the spirit world corresponds with the encounter of the colonized individual with the culture of the colonizer, where the transformation of her parents into pigs paralleled with the dehumanization and compromise of identity of the colonized. Chihiro’s renaming as Sen, language as a tool of control, and disturbing their sense of belonging highlights the colonial imposition on humans in the world of the spirits. The bathhouse in the film is symbolic of the colonized space where the identities, languages of the colonized are constructed and contested. The paper will also try to analyze how the protagonist takes up the journey towards self-discovery and reclaims her identity, culture, and autonomy in the midst of oppression.
Experimental Study of a PMDC Motor by dynamic response testing
Authors: Maheshwari Anay
Published: November 2024

This paper studies and investigates of the performance of permanent magnet D.C motors (PMDC motor) as well as determining the parameters of this type of motors at steady state. The study was carried out in two stages. The first stage involved the practical experimental to determine the parameters and characteristics of PMDC motor at steady state while the second stage centered on the simulation of mathematical modeling of this system using Simulink environment in MATLAB. The best significant results show that the computer simulations provide results closely to values of experimental measurements, therefore it can be used to investigate the performance of PMDC motors and their characteristics. In addition, the efficiency of PMDC motor is higher than Electromagnetic D.C motors, also the damping coefficient has a negative effect on characteristics of motor especially at no-load steady state in spite of smallness value. The paper includes the development of a lithium-ion battery pack and a static setup for simulating variable load cases on a PMDC motor.
Formulation and Evaluation of Polyherbal Soap
Authors: Mendake Rupali A. , Amalkar Shriyog V. , Hatwar Pooja Ramdas , Bakal Ravindra L.
Published: November 2024

The aim of the study is to formulate and evaluate Polyherbal soap using coconut oil, beeswax, NaOH(lye), Glycerine, Neem, aloe vera, Turmeric, Tulsi, Sandalwood powder, orange peel powder, Multani mitti, Reetha, Honey and Vitamin E capsule. The herbal formulation was prepared then evaluation of the analysis of Physical parameter, pH, Foam height, Foam retention time, Moiture content, Alcohol insoluble matter etc. Various study found that, these herbal plant extract proven to anti-bacterial activity, anti-inflammatory activity, anti-fungal activity etc. The finding for the herbal soap reveals that these soaps are cost effective, convenient, natural foam generate on application, not exhibit any skin irritation and less or no side effect.
Keywords: Polyherbal soap, Neem, Aloevera, Turmeric, Moisture content.
Isolation and Identification of Pathogenic Bacteria from Urinary Tract Infection in Patients Attending Rwanda Military Hospital
Authors: Alain Prudence ISHIMWE , Donatien MUTABAZI , Tharcisse GATEMBEZI , Philippe HAKIZIMANA , Viateur KANANURA , Lauben HABIYAREMYE
Published: November 2024

Background: About 150 million people worldwide are diagnosed with urinary tract infection every year and more than half of women will get at least one in their lifetimes. Overuse and misuse of antibiotics have contributed to the growing problem of resistance amongst uropathogenic bacteria making it hard to treat UTIs. There is an increasing prevalence of antibiotic resistance and that’s why area-specific monitoring studies to document the microorganisms causing UTIs and their antimicrobial susceptibility is mandatory for helping the selection of an effective empirical treatment.
Aim: The present study aimed to determine bacteria causing UTIs and their antibiotic susceptibility patterns among patients attending Rwanda military hospital.
Methodology: The study was a cross-sectional study and a total number of 118 patient’s urine samples were tested in microbiology Lab.
Results: Most frequently isolated bacteria to cause UTIs in this study was E. coli (59%) followed by Klebsiella pneumonia (16%), S. aureus (6%), Citrobacter freundii (5%), Proteus spp. (3%), S. Saprophyticus (3%), Streptococcus spp. (3%), Pseudomonas aeruginosa (2%), Klebsiella oxytosa (2%) and Acinetobacter baumanii (2%). Meropem, imipem, gentamicin and cefotaxime were the most effective antibiotics in susceptibility testing. Thus, ciprofloxacin, sulfamethoxazole and norfloxacin were mostly developed resistance to isolated bacteria.
Conclusion: The study recommended that the ministry of health in Rwanda should establish the commission or government body which will be in charge of controlling use of antibiotics properly and fighting against drugs resistance in Rwanda.
Keywords: Pathogenic bacteria, Urinary tract infections, E.coli, Antibiotics
Potential Inhibitor of DENV-2 Virus Protease (NS2B-NS3): An In-Silico Studies of Anti-Viral Plants
Authors: Rhakho Mhashevolu
Published: November 2024

Dengue virus (DENV) is a mosquito-borne pathogen that affects millions of people worldwide. The DENV-2 protease is a vital enzyme responsible for viral replication and is a promising target for antiviral therapy.  The objective of the study is to identify potential inhibitors of DENV-2 protease using In-Silico approaches with phytocompounds from ten antiviral plants. Initially, 133 phytoconstituents were collected with anti-dengue properties from previously reported studies which were virtually screened using SWISS ADME for ADME properties. The DENV-2 protease structure (2FOM) was obtained from the Protein Data Bank and molecular docking was performed using AutoDock Vina. The best-scoring compounds were evaluated and top five potential inhibitors with high binding affinity and stability were selected. The top-scoring compounds were Ligand-91 (Terchebin, -8.1 kcal/mol), Ligand-13 (7-desacetyl-7-benzoylgedunin, -7.8 kcal/mol), Ligand-100 (Triterpenoid, -7.8 kcal/mol), Ligand-12 (7-desacetyl-7-benzoylazadiradione, -7.7 kcal/mol), Ligand-20 (Azadirolic acid, -7.7 kcal/mol), Ref.1 (Doxycycline, -6.6 kcal/mol), Ref.2(Monosdenvir, -7.5 kcal/mol), and Ref.3 (Zanamivir, -5.6 kcal/mol). The result of the study shows that 7-desacetyl-7-benzoylazadiradione and 7-desacetyl-7-benzoylgeduninas compounds with high binding affinity for the target protein. These compounds are found in Azadirachta indica making it a promising candidate for further experimental validation and development of antiviral agents against DENV-2.
Keywords: Molecular docking, Anti-dengue, Anti-viral, ADME analysis
Formulation and Evaluation of Mucoadhesive Buccal Tablets of Carvedilol
Authors: Walse Prapti V. , Thoke Sandip T. , JADHAO UMESH THAWARA , Rathod Dharmaraj A. , Dhembre Gunesh D. , Kauthekar Vyankates R. , Ali Sayyed Asad
Published: November 2024

The aim of the study was to formulate and evaluate the carvedilol buccal tablets using HPMC K4M and xanthan gum as polymer. Buccal tablets of carvedilol were prepared by direct compression technique by using polymer in combination at different concentration. Drug excipient compatibility study indicates that there is no interaction between the excipient and the drug. Total seven batches were prepared and subjected to evaluation parameters. Pre-compression parameters for all batches showed excellent flow propertied of powder bled. Prepared buccal tablets were evaluated for various post compression parameters like hardness, thickness, weight variation, drug content, and friability, % swelling index, muco-adhesive strength and in vitro drug release. The harness of all batches was optimum showed good mechanical strength; thickness of tablets was uniform in all formulations the weight variation test of all the formulation was found to be within the limits of pharmacopoeial standard. % swelling index for all the batch formulation was optimum and seen to increase with increase in polymer concentration. Mucoadhesive strength was also showed acceptable results for all batch formulations which satisfy the need of mucoadhesive tablets. The in vitro dissolution profile of all the formulation showed sustained release of drug, for extended periods of time. The optimized formulation of F4 prepared with was consider as the optimized formulation with respect to drug content, % swelling index, Mucoadhesive strength and in vitro drug release pattern for 8 hrs. Formulation F4 showed highest 98.32±1.55 % drug release at the end of 8 hrs. Optimized formulation F4 was found to be stable during the stability studies for 3 month indicating good stability of the formulation.
Keywords: carvedilol, Mucoadhesive strength, Optimized formulation, buccal tablets.
Evaluation of spermatic DNA fragmentation in smoking normospermic infertile individuals
Authors: Karabat Mehmet Uğur , Akkuş Murat , Kaplan Şehmus , Sancar Muhyiddin , Atiç Esranur
Published: November 2024

Aim: In approximately 20% of infertile couples, the male factor is the only main cause. In recent years, it has been hypothesized that sperm DNA integrity may be a better indicator than routine semen analysis. Although the effects of smoking on male infertility have not yet been proven, smoking is considered a reasonable risk factor for infertility. In our study, we aimed to evaluate DNA damage in normospermic infertile men who smoke and do not smoke using the acridine orange method.
Material and Methods: This study was conducted on semen samples from 50 male cases, 25 of whom were smokers and non-smokers, who met the infertility criteria and applied to the urology clinic of Dicle University Medical Faculty Hospital. Microscopic examinations and morphological evaluations were performed in accordance with the WHO 2010 criteria. The acridine orange method was applied to evaluate DNA fragmentation and DNA fragmentations were calculated. Statistical analysis of the obtained data was performed using the Mann-Whitney U Test.
Results: In our study, in the smoking group, age was significantly associated with the duration of infertility, concentration with total motile sperm count, total sperm count with total motile sperm count, and amorphous head anomaly (p<0.01). In the non-smoking group, age and infertility were significantly associated with the duration, volume and total count, concentration and total count, total motile sperm count, and DNA fragmentation (p<0.01). However, there was no statistical difference between the smoking and non-smoking groups in terms of semen parameters and DNA fragmentation (p>0.05).
Conclusion: In order to obtain more reliable results, it is thought that large-scale studies are needed in the same groups and in the general population.
Keywords: sperm, infertility, DNA fragmentation, smoking
Analytical Techniques for the Determination of Metformin and its Combinations with Oral Antidiabetic Agents in Pharmaceutical Dosage Forms: Combinations with Sulphonylurea Antidiabetic Drugs
Authors: Abu Reid Imad Osman , Osman Sayda Mohamed , Bakheet Somia Mohammed
Published: November 2024

The sulfonylurea class of antidiabetic agents includes a range of closely related compounds, allowing for similar analytical approaches when combined with metformin. This article provides a comprehensive review of published methods for determining sulfonylureas and metformin combinations in bulk and pharmaceutical preparations. Various techniques such as high-performance liquid chromatography (HPLC), thin-layer chromatography (TLC), capillary zone electrophoresis (CZE), and spectrophotometric methods have been widely used for these compounds, yielding reliable results. Additionally, the article discusses the number of citations for each method and its specific purpose, offering critical commentary.
Keywords: metformin; sulphonylureas; combination; determination; analytical techniques
MOLECULAR MODELLING AND VIRTUAL SCREENING. APPLICATION TO THE COMPUTER-AIDED DESIGN OF ANTICANCER INHIBITORS WITH A FAVORABLE PHARMACOKINETIC PROFILE AGAINST E6 PAPILLOMAVIRUS TYPE 16
Authors: Bléhoué Ingrid Clémence , Koné Mawa , Esmel Elvice Akori , Fofana Issouf , Kéïta Mélalie , Megnassan Eugene
Published: November 2024

Background: Worldwide, cervical cancer (CC) is the fourth most common women cancer. It is crucial to develop more effective treatments for this disease. We aim at designing new anticancer compounds with a favorable pharmacokinetic profile, targeting the E6 oncoprotein of human papillomavirus type 16 (HPV16 E6).
Methods: Computer-Aided Molecular Design (CAMD) has been carried out by the elaboration of a Quantitative Structure-Activity Relationship (QSAR) model of molecular complexation, through the correlation between the relative Gibbs free energy (rGFE) and the observed biological activities of a series of flavonoids inhibitors separated in training (TS) and validation sets (VS). Starting from the 3D crystallographic structure of the oncoprotein HPV16 E6 (Protein Data Banck (PDB) input code: 4GIZ), enzyme – inhibitor complexes were built by in situ modification of the native ligand (FLAV1, IC50exp= 850 nM), replacing substitution R-groups at nine different positions R1 – R9.
Results: The complexation QSAR model equation (pIC50exp=-0.5494 × DDGcom+5.9983 (1); n=16; R2=0.98) explains 98% of the variation in biological activity by that of rGFE of the analogues used. The subsequent 3D pharmacophore model (PH4) generated from the active conformations of FLAVS (pIC50exp= 1.0177× pIC50pre – 0.0927(2); n=16; R2=0.90) was used as a virtual selection tool to identify new analogues from a virtual library (VL) reaching two digits nanomolar range predicted activity.
Conclusions: The combination of molecular modelling and in silico screening of VL using the PH4 pharmacophore has led to the discovery of new promising anticancer candidates, with favorable pharmacokinetic profiles against HPV16 E6. Among them, the top two predicted respective inhibitory powers IC50 pre (50 nM and 61 nM).
                  
Peer Review History:
Received 11 July 2024;   Reviewed 16 September 2024; Accepted 20 October; Available online 15 November 2024
Academic Editor: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, gehankandeel9@yahoo.com 
Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 8.5/10
Reviewers:
Dr. Ogbonna B. Onyebuchi, Nnamdi Azikiwe University, Awka,  Nigeria, summitpharm@yahoo.com
Prof. Syamsudin Abdillah, Pancasila University, Indonesia, syamsudin.abdillah@gmail.com
Transmisión espacial y vertical de los precios de leche del mercado internacional a mercados regionales y nacional de México
Authors: González Ortiz Benigna , Jaramillo Villanueva José Luis , Vargas López Samuel , Bustamante González Ángel , Guerrero Rodríguez Juan de Dios , Santoyo Cortés Vinicio Horacio
Published: November 2024

Cuando un país importa un bien o servicio se sujeta a los precios determinados por el mercado mundial, por lo tanto, los precios del mercado interno cambian cuando los precios internacionales lo hacen. El objetivo de este estudio fue estimar el grado de transmisión de precios entre el precio al productor de leche en México a nivel nacional y regional y el de Estados Unidos (transmisión espacial), así como entre el precio de la leche al menudeo y el precio al productor en México (transmisión vertical). Se realizó un análisis econométrico de series de tiempo mensuales de los precios de leche de enero de 1990 a diciembre de 2021, aplicando pruebas de raíz unitaria, de cointegración y un modelo de vectores de corrección de error. Los resultados indican que existe una relación a largo plazo de los precios de Estados Unidos con los precios al productor a nivel nacional y regional, así como entre el precio al menudeo y el precio al productor. Se encontró que la transmisión espacial de los precios internacionales al precio al productor a nivel nacional y regional en Jalisco y Veracruz es de forma simétrica, y asimétrica con el precio al productor en el estado de Coahuila. Existen diferencias entre regiones en la velocidad de ajuste cuando los precios internacionales aumentan que cuando disminuyen. La transmisión vertical también fue de forma simétrica, unidireccional del productor al mercado minorista e incompleta.
Momento de la suplementación sobre carga animal y producción de leche por hectárea de vacas Holstein en pastoreo
Authors: Castro Jaime Citlali Anais , Ramírez Valverde Rodolfo , Burgueño Ferreira Juan Andrés , Ramírez-Bribiesca Jacinto Efrén , Miranda Romero Luis Alberto , Améndola Massiotti Ricardo Daniel
Published: November 2024

El objetivo fue evaluar, en pastoreo de praderas mixta de Medicago sativa L. y Dactylis glomerata L., la respuesta de vacas Holstein Neozelandés a la suplementación con concentrado en diferentes momentos del día, sobre producción individual, carga animal y producción de leche por hectárea. Se realizaron dos experimentos, en invierno y en primavera-verano, con un diseño cruzado 3×3. Los tratamientos fueron tres momentos de oferta de concentrado (5.0 kg de MS vaca-1 día-1) como suplemento luego de la ordeña matinal (AM), de la vespertina (PM), y dividido equitativamente en ambas ordeñas (AM-PM). Las unidades experimentales fueron lotes de seis (invierno) o cinco vacas (primavera-verano) y sus respectivas áreas de pastoreo, mismas que recibieron los tratamientos. El criterio de manejo del pastoreo rotacional fue 8 cm de altura de forraje residual para todos los tratamientos; esto permitió estimar el efecto de los tratamientos sobre la carga animal. No hubo efecto  (P>0.05)  sobre carga animal.  La producción de leche  por vaca en  AM fue 10.2 % superior que los otros dos tratamientos en promedio, tanto en invierno (8.6 %, P=0.0002), como en primavera-verano (11.7 %, P<0.0001). El incremento en producción de leche por ha (9 %) se debió a la respuesta individual y no a diferencias en carga animal. El criterio de manejo de pastoreo con altura única de forraje residual permitió, de modo sencillo, estimar la respuesta en carga animal y con ello la producción de leche por hectárea.
Manejo del pasto elefante de riego intercalado con leguminosas en la región semiárida
Authors: do Vale Bezerra Jéssica Daisy , Emerenciano Neto João Virgínio , Da Cruz da Silva Tamiris , Fernandes Patrick Bezerra , Antas Urbano Stela , Pontes Teixeira das Chagas Felipe , Dos Santos Difante Gelson , Geraldo Costa Marcone , Chaves Gurgel Antonio Leandro , Lopes Sousa Francisco Israel , Da Silva Santos Rodrigo , Graciano da Costa Ana Beatriz
Published: November 2024

El presente estudio tuvo como objetivo evaluar la producción y composición química del pasto elefante (Pennisetum purpureum sin. Cenchrus purpureus cv. Mott) intercalado con Cajanus cajan (Mandarim y Fava Larga) y Stylosanthes guianensis (Bela) en comparación con su cultivo en monocultivo bajo manejo de riego en la región semiárida. El experimento se llevó a cabo en el Campus de Ciencias Agrícolas de la Universidad Federal del Valle de São Francisco, Petrolina, Brasil. El experimento consistió en los siguientes tratamientos: pasto elefante intercalado con cada leguminosa y dos tipos de monocultivo, uno con fertilización nitrogenada (200 kg ha-1) y el otro sin ella. Las leguminosas ayudaron a mejorar la calidad del dosel forrajero, con altos niveles de proteína cruda. La fertilización nitrogenada aumentó la masa de forraje producido por el pasto elefante. El análisis acumulativo de todos los cortes mostró que el cultivo intercalado de elefante con el cultivar Bela logró el mayor rendimiento,  con 13.49 Mg ha-1, debido principalmente al aumento en la población de Bela, que demostró ser superior a las otras leguminosas a lo largo de los cortes. Con base en los resultados, se recomienda el cultivo intercalado de elefante con el cultivar Bela como la estrategia más efectiva para maximizar la producción de forraje en la región semiárida.
O Melodrama no Cinema Brasileiro: uma análise histórica a partir dos conceitos de Gênero e Modo
Authors: Terao David
Published: November 2024

Buscando sistematizar a presença do melodrama no cinema brasileiro, este artigo fará uma análise histórica de sua condição enquanto gênero cinematográfico nos estúdios dos anos 1930 a 1950 e depois, compreendendo a limitação metodológica dessa categoria, será feita uma revisão conceitual do melodrama dentro da categoria “modo”. Através dessa noção que extrapola as restrições dos gêneros, podemos entender o melodrama como forma de “modulação” dos elementos da mise-en-scène em direção a um excesso que intensifica a adesão emocional do espectador e lhe propõe uma experiência pedagógica através da narrativa. Para trazer um exemplo de como o melodrama “modula” a encenação cinematográfica e consequentemente a experiência do espectador, será apresentada uma análise fílmica de algumas cenas de Eles não usam black-tie (Leon Hirszman, 1981) para assim compreender a permanência do modo melodramático no cinema brasileiro.
Suburbanismo Fantástico como Ferramenta Genérica Hollywoodiana para adaptar Narrativas Infanto-Juvenis
Authors: Baptista Lauria Pedro Artur
Published: November 2024

O suburbanismo fantástico é um dos subgêneros cinematográficos mais influentes do cinema estadunidense da década de 1980. Dentre seus clássicos estão aventuras infanto-juvenis da Amblin (produtora de Steven Spielberg) como Poltergeist, E.T, Gremlins, De Volta para o Futuro e Os Goonies. O mesmo foi categorizado recentemente por Angus McFadzean, após o retorno da popularidade do subgênero na década de 2010 em obras como Super 8 e Stranger Things que foram vendidas como “ficções científicas nostálgicas dos anos 1980” e “obras estilo Amblin”. Na busca por uma melhor consolidação do que é o suburbanismo fantástico, o presente artigo demonstra como parte importante do seu desenvolvido se dá através de uma replicação do modelo de E.T. e Poltergeist de adaptar blockbusters e obras de outros gêneros cinematográficos, em narrativas centradas em crianças, adolescentes e jovens adultos. Este olhar ressalta como o subgênero foi parte importante do período do “Entretenimento Reaganista” ao adaptar o modelo de blockbusters para o público com maior potencial de consumo no cinema estadunidense: o jovem suburbano. Por fim, o artigo também o impacto que o suburbanismo fantástico vai ter em outros gêneros da indústria a partir da década de 1980.
O Dossiê - apresentação
Authors: Baltar Mariana , Castanha Cesar , Amaral Carolina
Published: November 2024

Apresentação do Dossiê "O que podem os gêneros narrativos no cinema e audiovisual?"
Mediação assistida por animais
Authors: Pinheiro Mariza Inês da Silva , Dos Santos Raquel Goulart
Published: November 2024

A mediação de leitura exercida através da utilização de animais para ajudar crianças a desenvolver uma maior disposição à leitura oferecida em bibliotecas, escolas, creches, hospitais, abrigos de animais, fazendas, santuários, entre outros, pode ser uma realidade. Esta pesquisa teve por objetivo analisar na literatura científica a existência e/ou prática de incentivo a leitura com animais realizados pelo profissional bibliotecário. As fontes de informações pesquisadas foram: Portal de Periódicos Capes, Brapci, BDTD, Google Acadêmico, Google, jornais e blogs. Apresenta várias experiências nacionais e internacionais de leitura assistida por animais. Os principais autores estudados foram Gee (2012, 2017) e Calado (2016). Assim, constatou-se através da literatura que a mediação feita com animais para auxiliar a leitura é benéfica e praticável para as crianças. Entretanto, nas bases de dados pesquisadas foi pouco disseminada através da literatura científica na área da Biblioteconomia internacional. Em relação à nacional os resultados foram nulos, apenas notícias em jornais e blogs sobre casos relatados de práticas da Mediação Assistida por Animais - MAA.
A Comunicação Aumentativa e Alternativa na Educação Infantil e a Produção Científica no Brasil e em Portugal
Authors: Estabel Lizandra Brasil , Vaz Cátia
Published: November 2024

Este estudo se caracteriza como uma análise acerca das produções científicas referente à temática de Comunicação Aumentativa e Alternativa (CAA) para crianças com Transtorno do Espectro Autista na Educação Infantil, no período de 2017 a 2021. Trata-se de uma pesquisa exploratória, de revisão bibliográfica, transversal e de caráter qualitativo e quantitativo. Para a realização deste estudo foi utilizado o Portal Brasileiro de Acesso Aberto à Informação Científica – oasisbr gerido pelo Instituto Brasileiro de Informação em Ciências e Tecnologia (IBICT) por meio da base de dados (https://oasisbr.ibict.br). A premissa para seleção das produções científicas foram os estudos vinculados às temáticas: Comunicação Aumentativa e Alternativa e palavras correlatas, Transtorno do Espectro Autista e Educação Infantil no Brasil e Portugal. Com base nos critérios de seleção foram computados 8 trabalhos no período de 2017 a 2021. A partir dos dados coletados e analisados, verificou-se a importância do uso da Comunicação Aumentativa e Alternativa possibilitando recursos que promovem habilidades comunicativas verbais da criança, em idade pré-escolar, ampliando seu espaço de participação promovendo e enriquecendo seu processo de aprendizagem.
Cooperativismo na Biblioteconomia
Authors: Pimentel Cavalcante Annelise , Pimentel Cavalcante Marta Maria
Published: November 2024

A proposta deste artigo Consiste em apresentar o empreendedorismo cooperativo a partir do estudo de caso da Cooperativa de Trabalho Nacional dos Bibliotecários e Profissionais da Informação (Bibliocoop), cooperativa de Bibliotecários localizada em Alagoas. Dessa forma, como objetivos secundários, busca-se analisar como a atuação do bibliotecário numa cooperativa empreendedora pode trazer benefícios para a área e para a inserção do próprio profissional no mercado de trabalho. A abordagem metodológica utilizada foi pesquisa bibliográfica utilizando o método estudo de caso por meio da análise da Bibliocoop que mostrou que os profissionais cooperados, podem estar usufruindo dos benefícios gerados por intermédio do empreendimento cooperativo. Por fim, conclui-se que o tema abordado contribui para a geração de empregos e uma boa alternativa de inserção profissional para a área da Biblioteconomia.
Gestão da informação e do conhecimento
Authors: Ziviani Fabricio , De Souza Toledo Marcos Vinícius , De Souza Toledo Bruno , Dutra de Carvalho Lemos Karina
Published: November 2024

No contexto atual, a gestão da informação e do conhecimento são fatores imprescindíveis ao diferencial competitivo da organização, sendo necessário cada vez mais ampliar os estudos destes dois termos. O objetivo desta pesquisa é realizar uma análise bibliométrica das publicações em revistas brasileiras com os temas gestão do conhecimento e da informação identificando a aplicação das cinco leis da bibliometria. De natureza básica, com tipologia exploratória e descritiva, a pesquisa adotou como método a pesquisa bibliográfica e os estudos bibliométricos. A partir da abordagem quantitativa, foram selecionadas e analisadas as produções científicas na área da Ciência da Informação, que apresentam em seu título e termos indexados, os termos tais como: gestão do conhecimento, gestão da informação e gestão da informação e do conhecimento. O corpus da pesquisa foi constituído pelos artigos publicados até junho de 2019 em periódicos nacionais com Estrato Qualis-Periódicos A1, A2 e B1 na área da Ciência da Informação. Como resultados, apresentou-se uma análise estatística descritiva dos 565 artigos pesquisados. Além disso, por meio das cinco análises bibliométricas mediu-se a produtividade dos autores para delimitar os conteúdos da área, frequências de palavras-chave, recuperação de artigos em periódicos científicos eletrônicos e a elite de autores produtores de artigos. Conclui-se que com as análises bibliométricas, foram construídos indicadores sobre a dinâmica e a evolução da gestão da informação e do conhecimento em 10 revistas nacionais da área analisada.
usabilidade e o comportamento informacional como estratégia de melhoria do Portal de Transparência da UFRN
Authors: Bezerra de Araujo Saul Lincoln
Published: November 2024

O presente artigo tem como objetivo abordar a importância da usabilidade e do comportamento informacional como estratégia de melhoria do portal de transparência da UFRN e avaliar como as informações estão dispostas em seu portal. Assim, dentro dessa temática, pode-se observar que, mesmo com os dispositivos legais que disciplinam o tema, é preciso que melhorias e correções sejam realizadas dentro desse complexo arcabouço conceitual. Dada a importância dos portais de transparência como uma maneira de exercer a cidadania, fiscalizar e contribuir no combate a corrupção é dever dos órgãos disponibilizarem as informações necessárias e que as mesmas estejam em uma linguagem focada no usuário. Como metodologia trata-se de uma pesquisa com abordagem qualitativa; quanto aos meios, utiliza-se a pesquisa bibliográfica  juntamente com a análise do portal da UFRN; quanto aos fins, classifica-se como uma pesquisa descritiva. Desse modo, a formação de critérios que padronizem a maneira de como se dá a apresentação das informações, contribuem para que os usuários se sintam mais confortáveis ao efetuarem a busca por estas. Assim, todo esse contexto, vai ao encontro da forma direta e efetiva para o fortalecimento de um estado democrático e participativo no combate a corrupção.
Unveiling hidden opportunities: a case study on the perception of affordances in informal english learning activities mediated by technology in a fl teacher-training program
Authors: Acosta López Juan Carlos
Published: November 2024

This qualitative single-case study explored the perceived affordances of informal activity systems mediated by online technologies for promoting English language learning among 115 FL teachers-in-training at UNAD. The study employed a word-based questionnaire administered to the entire sample, followed by small focus group interviews with 20 purposively selected participants, (Morgan & Hoffman, 2018). The resulting data were analyzed using a dynamic and fluid 2-cycle coding procedure. The findings show that learners’ ability to per-ceive and engage with technological, social, metacognitive, and language learning affordances significantly influences their engagement with technology-mediated activities and their level of success in acquiring a for-eign language. Notably, perceiving physical affordances serves as a prerequisite for perceiving more complex affordances, such as educational and social ones. This research significantly contributes to the advancement of knowledge regarding informal English learning mediated by online technologies, with a particular focus on distance education models. The study highlights the importance of fostering learners’ autonomous learning skills, given that most of the language learning in such models occurs in informal settings, and it discusses the need to leverage online resources to maximize language FL affordances for FL teachers-in-training, ultimately enhancing their language learning outcomes.
Experiencia significativa: la cooperación académica e investigativa binacional entre la UNAD y FLACSO, una perspectiva desde el grupo de investigación en Etnoeducación y estudios raciales
Authors: Prado Morales Dayan Marcela
Published: November 2024

La cooperación académica e investigativa binacional entre la Universidad Nacional Abierta y a Distancia (UNAD) y la Facultad Latinoamericana de Ciencias Sociales (FLACSO) ha sido de vital importancia en ámbitos educa-tivos, científicos, sociales y ambientales. Ambas i nstituciones han emprendido el compromiso de promover el desarrollo académico, social y a mbiental en sus respectivos países y en las regiones fronterizas en las que tienen incidencia. Es por ello, que las investigaciones situadas han permitido potenciar el intercambio de conocimientos y expe-riencias entre docentes, investigadores y estudiantes de ambas instituciones. Esto ha facilitado el enriqueci-miento mutuo y la generación de nuevas perspectivas en temas de interés común, como la educación propia, los conflictos étnicos socioambientales y la salvaguarda de los patrimonios naturales fronterizos. En esencia, la colaboración investigativa binacional entre ambas instituciones ha fortalecido la capacidad de investigación y la producción científica en áreas prioritarias para el desarrollo de la región (especialmente las zonas de integración fronteriza). Mediante la realización de proyectos conjuntos, se ha potencializado la inves-tigación colaborativa, el intercambio de metodologías y la obtención de resultados compartidos más sólidos y relevantes. Esto sin lugar a duda, ha contribuido al avance del conocimiento y a la generación de soluciones a problemáticas comunes.
Lawn - universal human space beyond suburbia
Authors: Jacob Neman
Published: November 2024

Visual analysys of a lawn in a public and private space as a universally understood image of wealth , leisure , minimalist aesthetic
Reflections of user satisfaction in public spaces: A structural equation modeling approach at Hasanpaşa Gazhane, Istanbul
Authors: Türkoğlu Sezen , Terzi Fatih
Published: November 2024

This study investigates the factors that influence user satisfaction with public spaces by using structural equation modeling (SEM). The case study focuses on Hasanpa?a Gazhane (Gashouse), a versatile public space located in a central area of Istanbul, attracting a diverse range of individuals from various demographic, social, and economic backgrounds. Using a random sampling technique, 203 face-to-face surveys were conducted to assess users? perceptions of accessibility, use and activity, safety, comfort, and image indicators, as well as user satisfaction. Preliminary data analysis employed exploratory factor analysis and reliability analysis methods. Subsequently, the relationship between the identified factors and user satisfaction was analyzed using structural equation modeling in Amos 24 software. The findings indicate that user satisfaction in public places is mostly influenced by the use and activities and image indicators. Accessibility, safety, and comfort factors have a relatively lesser impact on user satisfaction. The results focus on adapting public space design and management techniques to the needs and expectations of the community. This study makes a valuable contribution to the diversification of methodologies used in the study of sitespecific attributes within public spaces, with a particular emphasis on optimizing their responsiveness to the needs and expectations of users.
Survival outcomes for HER2-low breast cancer: Danish national data
Authors: Sode Michael , Nielsen Kåre , Jensen Maj-Britt , Berg Tobias , Knoop Ann , Ejlertsen Bent , Lænkholm Anne-Vibeke
Published: November 2024

Background and purpose: We investigated the prognosis of breast cancer (BC) with low expression of human epidermal growth factor receptor 2 (HER2), as previous studies have found varying impacts on survival of HER2-low BC compared with HER2 0 BC (HER2 IHC score of 0). HER2-low is defined as a score of 1+ or 2+ in an immunohistochemical (IHC) assay without HER2 gene amplification.
Materials and methods: Patients with HER2 0 or HER2-low BC from the national Danish Breast Cancer Group database were examined by multivariable survival analysis in a retrospective noninterventional investigation. Patients were grouped as either HER2 0 or HER2-low. The primary endpoint was time to recurrence (TR), and the secondary endpoints were overall survival (OS) and distant recurrence-free interval (DRFI).
Results: 41,610 patients were included (12,981 with HER2 0 BC and 28,629 with HER2-low BC). HER2-low BC was associated with a lower risk of recurrence (hazard ratio [HR]: 0.92, p = 0.03). Regarding secondary endpoints, HER2-low disease was linked to improved overall OS (HR: 0.94, p = 0.02). No statistically significant effect of HER2-low was found for DRFI, along with no differential effect of HER2-low according to estrogen receptor (ER) status.
Interpretation: HER2-low BC was found to show an improved HR for OS and DRFI compared with HER2 0 BC; however, further studies are need to establish whether it represents a separate biological entity.
Juridical Reasoning for the Distribution of Pharmaceutical Preparations that Failed the Efficacy Test in Court Decisions
Authors: Febriansyah Ferry Irawan , Richard Tomlins  , Ulya Shafa Firdausi  , Yusuf Adam Hilman
Published: November 2024

ABSTRACT
Purpose of thestudy (Tujuan) : The purpose of this research is to determine the judge's considerations in imposing sanctions on pharmaceutical distributors who do not meet the efficacy and quality standards by the Ponorogo district court decision Number 115/Pid.Sus/2023/PN Png using juridical analysis.
 Methodology (Metodologi): The methodology used is a normative research method or library research method.
Results (Temuan): The results of this research are that there are cases of distribution of drugs that do not match the efficacy and quality, violating the protection rights of consumers. The government and BPOM are expected to pay more attention to the pharmaceutical production process and provide education to the lay public in the pharmaceutical sector so that the public obtain safe and quality pharmaceutical products. Ponorogo District Court Decision Number 115/Pid, Sus/2023/PN Png The panel of judges considered evidence, legal interpretation, and ethics during the trial. This case violates Law Number 36 of 2009 Article 196 concerning Health. By considering this, circumstances emerged that mitigated and aggravated the defendant and also used the theory of will and the theory of knowledge so that he was charged with imprisonment for 1 (one) year and a fine of IDR 5,000,000.00 (five million rupiah) provided that the fine was not paid to be replaced by imprisonment for one month. The decision at the Ponorogo District Court provides a solid foundation for future courts in handling similar cases.
Applications of this study (Kegunaan): The use of this research can be an in-depth understanding of the decision ratio in the Ponorogo District Court Decision for both perpetrators, legal practitioners, academics, and policymakers for future directions.
Novelty/ Orginalty of this study (Kebaruan/Orisinalitas): The difference with previous studies is that the focus of this research is the location of the research, the type of drug used and the district court decision
Epinephrine: A Review of Current Understanding and Future Direction
Authors: Ketchem Justin , Ketchem Elizabeth , Mishra Samarth , Kapuria Rohan , Majeed Ban , Walsh David , Islam K.M.
Published: November 2024

Introduction: The administration of injectable epinephrine is a widely utilized mechanism which has been employed as a lifesaving medication for decades. Despite the prevalence of this treatment technique, certain situations and patient populations necessitate a replacement for the epinephrine auto injector (EAI). There are several disadvantages of traditional EAIs. These drawbacks include high cost, short shelf life, low carry rate, difficulty to use or train with, fear of needles, fixed dosages, and fixed needle length. The most promising EAI alternatives include sublingual tablets and intranasal spray. These delivery methods have similar pharmacological effectiveness to EAIs with the benefits of modifiable dosages, high stability, and simplified administration. This review aims to evaluate deficiencies in implementation of the currently used EAI, investigate newly developed alternative delivery methods, identify gaps in the current literature, and suggest possible future studies.
Central Airway Stenting as a Palliative Procedure in A Patient with Critical Airway Stenosis
Authors: Isidro Fracasso João , Dezordi Dall'Agnol Amanda , Benincá Albuquerque Antônio , Boeira Rovani André Luca , Beltrame Cássia , Baroni de Macedo Guilherme , Priori Leonardo , Branco Schweitzer Mendes Nathalia , Teixeira Simon Thiago , Buaes Dal Maso Vinícius
Published: November 2024

Stents are devices designed to maintain the patency of tubular structures. Airway stents are placed in the central tracheobronchial tree and used either for malignant obstruction or for benign diseases. Their use is indicated in both intrinsic obstruction or extrinsic compression of the airway. We present a case of a 60-year-old female patient with an extrinsic mass obstructing the tracheal lumen, presenting with progressive dyspnea at the slightest effort, in which a stent was successfully placed as a palliative procedure.
A Data-Driven Model for Classification of Traditional Chinese Medicine Materials
Authors: Zhi-Jie Li
Published: November 2024

This paper proposes a data-driven classification model for traditional Chinese medicinal herbs based on mid-infrared spectral data. Addressing the limitations of traditional identification methods when the herbs’ appearance is damaged or incomplete, this study employs machine learning techniques to achieve accurate classification of medicinal herb types through spectral data preprocessing and feature extraction. Firstly, the Savitzky-Golay convolution smoothing method and Standard Normal Variate (SNV) transformation were used for denoising the spectral data. Then, Principal Component Analysis (PCA) was employed to reduce the dimensionality of the high-dimensional spectral data and extract the key features. Finally, the Gaussian Mixture Model (GMM) was applied to cluster the reduced data, categorizing the medicinal herbs into six classes. The results show that this method produces the accurate and stable classification. The constructed model is not only applicable to the classification and origin identification of medicinal herbs but also provides an important reference value for the classification and origin identification of other plant species.
Pracovné právo pre ekonómov
Authors: Slivka Bedlovičová Jana
Published: November 2024

Cvičebnica poskytuje prierezový náhľad na všetky fundamentálne otázky pracovného práva, s ktorými sa budúci ekonómovia v ich praxi stretnú. Cvičebnica je členená na 15 kapitol a zaoberá sa predovšetkým pracovným pomerom ako pracovnoprávnym vzťahom a s ním súvisiacimi témami - od identifikácie prvkov pracovnoprávneho vzťahu, cez vznik pracovného pomeru, až po jeho zánik. Cvičebnica neobchádza dôležité témy ako napríklad pracovný čas a doba odpočinku, odmeňovanie, prekážky v práci, sociálna politika zamestnávateľa a nevyhnutná pracovná disciplína. Na záver stručne charakterizuje dohody o prácach vykonávaných mimo pracovného pomeru, ako aj kolektívne pracovnoprávne vzťahy.
GENDER (IN)EQUALITY AND ACTIVE AGEING IN SIBERIAN REGIONS
Authors: Frolova E.A. , Malanina V.A. , Klemasheva E.I. , Kashapova E.R.
Published: November 2024

In this article we aim to identify the origins and outcomes of the gender gap among older adults of Siberian Federal District of Russia. We apply the Active Ageing Index (AAI) methodology to process the data from European Social Survey (ESS-2016) and Comprehensive monitoring of living conditions (CMLC-2016) of the population with regard of Russian older adults’ quality of life. We have identified the indicators of gender inequality among older adults in Siberia. Men are 1.3 times more employed, their income is on average 1.13 times higher, they have 1.4 times lower poverty risk compared to women. In spheres of physical activity and educational attainment we observe no gender gap. The results show that low employment among older women contributes most to the gender gap in Siberian regions. Women are three times more involved in participation in society compared to men. Counterintuitively, women are only 8% more involved in providing care to children and grandchildren. The lowest potential for active ageing is indicated in Kemerovo region, the highest potential in Novosibirsk region. The only region with reverse gender gap in active ageing is the Republic of Tyva. Thus, the ageing process in Russia turns out to be gendered, although on average the gap in narrower than in European Union (2.12 vs 3 percentage points).