bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation on the Injury Severity of Drivers in Rear-End Collisions Between Cars Using a Random Parameters Bivariate Ordered Probit Model
Authors: Chen Feng , Song Mingtao , Ma Xiaoxiang
Published: July 2019

The existing studies on drivers’ injury severity include numerous statistical models that assess potential factors affecting the level of injury. These models should address specific concerns tailored to different crash characteristics. For rear-end crashes, potential correlation in injury severity may present between the two drivers involved in the same crash. Moreover, there may exist unobserved heterogeneity considering parameter effects, which may vary across both crashes and individuals. To address these concerns, a random parameters bivariate ordered probit model has been developed to examine factors affecting injury sustained by two drivers involved in the same rear-end crash between passenger cars. Taking both the within-crash correlation and unobserved heterogeneity into consideration, the proposed model outperforms the two separate ordered probit models with fixed parameters. The value of the correlation parameter demonstrates that there indeed exists significant correlation between two drivers’ injuries. Driver age, gender, vehicle, airbag or seat belt use, traffic flow, etc., are found to affect injury severity for both the two drivers. Some differences can also be found between the two drivers, such as the effect of light condition, crash season, crash position, etc. The approach utilized provides a possible use for dealing with similar injury severity analysis in future work.
Correction: An, F., et al. A Conjugate of Pentamethine Cyanine and 18F as a Positron Emission Tomography/Near-Infrared Fluorescence Probe for Multimodality Tumor Imaging. Int. J. Mol. Sci. 2017, 18, 1214
Authors: An Fei-Fei , Kommidi Harikrishna , Chen Nandi , Ting Richard
Published: July 2019

The authors wish to make the following corrections to this paper [...]
Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis
Authors: de Oliveira Analú Barros , Ferrisse Túlio Morandin , Marques Raquel Souza , de Annunzio Sarah Raquel , Brighenti Fernanda Lourenção , Fontana Carla Raquel
Published: July 2019

The aim of this study was to perform a systematic review of the literature followed by a meta-analysis about the efficacy of photodynamic therapy (PDT) on the microorganisms responsible for dental caries. The research question and the keywords were constructed according to the PICO strategy. The article search was done in Embase, Lilacs, Scielo, Medline, Scopus, Cochrane Library, Web of Science, Science Direct, and Pubmed databases. Randomized clinical trials and in vitro studies were selected in the review. The study was conducted according the PRISMA guideline for systematic review. A total of 34 articles were included in the qualitative analysis and four articles were divided into two subgroups to perform the meta-analysis. Few studies have achieved an effective microbial reduction in microorganisms associated with the pathogenesis of dental caries. The results highlight that there is no consensus about the study protocols for PDT against cariogenic microorganisms, although the results showed the PDT could be a good alternative for the treatment of dental caries.
LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer
Authors: Laurentino Talita de S. , Soares Roseli da S. , Marie Suely K. N. , Oba-Shinjo Sueli M.
Published: July 2019

Lysyl oxidase like 3 (LOXL3) is a copper-dependent amine oxidase responsible for the crosslinking of collagen and elastin in the extracellular matrix. LOXL3 belongs to a family including other members: LOX, LOXL1, LOXL2, and LOXL4. Autosomal recessive mutations are rare and described in patients with Stickler syndrome, early-onset myopia and non-syndromic cleft palate. Along with an essential function in embryonic development, multiple biological functions have been attributed to LOXL3 in various pathologies related to amino oxidase activity. Additionally, various novel roles have been described for LOXL3, such as the oxidation of fibronectin in myotendinous junction formation, and of deacetylation and deacetylimination activities of STAT3 to control of inflammatory response. In tumors, three distinct roles were described: (1) LOXL3 interacts with SNAIL and contributes to proliferation and metastasis by inducing epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma cells; (2) LOXL3 is localized predominantly in the nucleus associated with invasion and poor gastric cancer prognosis; (3) LOXL3 interacts with proteins involved in DNA stability and mitosis completion, contributing to melanoma progression and sustained proliferation. Here we review the structure, function and activity of LOXL3 in normal and pathological conditions and discuss the potential of LOXL3 as a therapeutic target in various diseases.
Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus
Authors: Chuang Yao-Chung , Chen Shang-Der , Jou Shuo-Bin , Lin Tsu-Kung , Chen Shu-Fang , Chen Nai-Ching , Hsu Chung-Yao
Published: July 2019

Status epilepticus may decrease mitochondrial biogenesis, resulting in neuronal cell death occurring in the hippocampus. Sirtuin 1 (SIRT1) functionally interacts with peroxisome proliferator-activated receptors and γ coactivator 1α (PGC-1α), which play a crucial role in the regulation of mitochondrial biogenesis. In Sprague-Dawley rats, kainic acid was microinjected unilaterally into the hippocampal CA3 subfield to induce bilateral seizure activity. SIRT1, PGC-1α, and other key proteins involving mitochondrial biogenesis and the amount of mitochondrial DNA were investigated. SIRT1 antisense oligodeoxynucleotide was used to evaluate the relationship between SIRT1 and mitochondrial biogenesis, as well as the mitochondrial function, oxidative stress, and neuronal cell survival. Increased SIRT1, PGC-1α, and mitochondrial biogenesis machinery were found in the hippocampus following experimental status epilepticus. Downregulation of SIRT1 decreased PGC-1α expression and mitochondrial biogenesis machinery, increased Complex I dysfunction, augmented the level of oxidized proteins, raised activated caspase-3 expression, and promoted neuronal cell damage in the hippocampus. The results suggest that the SIRT1 signaling pathway may play a pivotal role in mitochondrial biogenesis, and could be considered an endogenous neuroprotective mechanism counteracting seizure-induced neuronal cell damage following status epilepticus.
Cell Death in the Kidney
Authors: Priante Giovanna , Gianesello Lisa , Ceol Monica , Del Prete Dorella , Anglani Franca
Published: July 2019

Apoptotic cell death is usually a response to the cell’s microenvironment. In the kidney, apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal injury, but does not trigger an inflammatory response. What distinguishes necrosis from apoptosis is the rupture of the plasma membrane, so necrotic cell death is accompanied by the release of unprocessed intracellular content, including cellular organelles, which are highly immunogenic proteins. The relative contribution of apoptosis and necrosis to injury varies, depending on the severity of the insult. Regulated cell death may result from immunologically silent apoptosis or from immunogenic necrosis. Recent advances have enhanced the most revolutionary concept of regulated necrosis. Several modalities of regulated necrosis have been described, such as necroptosis, ferroptosis, pyroptosis, and mitochondrial permeability transition-dependent regulated necrosis. We review the different modalities of apoptosis, necrosis, and regulated necrosis in kidney injury, focusing particularly on evidence implicating cell death in ectopic renal calcification. We also review the evidence for the role of cell death in kidney injury, which may pave the way for new therapeutic opportunities.
Dissecting Adaptation Mechanisms to Contrasting Solar Irradiance in the Mediterranean Shrub Cistus incanus
Authors: Sebastiani Federico , Torre Sara , Gori Antonella , Brunetti Cecilia , Centritto Mauro , Ferrini Francesco , Tattini Massimiliano
Published: July 2019

Molecular mechanisms that are the base of the strategies adopted by Mediterranean plants to cope with the challenges imposed by limited or excessive solar radiation during the summer season have received limited attention. In our study, conducted on C. incanus plants growing in the shade or in full sunlight, we performed measurements of relevant physiological traits, such as leaf water potential, gas exchange and PSII photochemistry, RNA-Seq with de-novo assembly, and the analysis of differentially expressed genes. We also identified and quantified photosynthetic pigments, abscisic acid, and flavonoids. Here, we show major mechanisms regulating light perception and signaling which, in turn, sustain the shade avoidance syndrome displayed by the ‘sun loving’ C. incanus. We offer clear evidence of the detrimental effects of excessive light on both the assembly and the stability of PSII, and the activation of a suite of both repair and effective antioxidant mechanisms in sun-adapted leaves. For instance, our study supports the view of major antioxidant functions of zeaxanthin in sunny plants concomitantly challenged by severe drought stress. Finally, our study confirms the multiple functions served by flavonoids, both flavonols and flavanols, in the adaptive mechanisms of plants to the environmental pressures associated to Mediterranean climate.
Revealing Adenosine A2A-Dopamine D2 Receptor Heteromers in Parkinson’s Disease Post-Mortem Brain through a New AlphaScreen-Based Assay
Authors: Fernández-Dueñas Víctor , Gómez-Soler Maricel , Valle-León Marta , Watanabe Masahiko , Ferrer Isidre , Ciruela Francisco
Published: July 2019

Background: Several biophysical techniques have been successfully implemented to detect G protein-coupled receptors (GPCRs) heteromerization. Although these approaches have made it possible to ascertain the presence of GPCR heteromers in animal models of disease, no success has been accomplished in pathological human post-mortem brains. The AlphaScreen technology has been consistently used to quantify small analyte accumulation or depletion, bimolecular interactions, and post-translational modifications. The high signal-to-background, dynamic range and sensitivity exhibited by this technology support that it may be suitable to detect GPCR heteromers even under non-optimal conditions. Methods: Here, we describe the development of a new AlphaScreen assay to detect GPCR oligomers in human post-mortem brain. Results: Adenosine A2A-dopamine D2 receptor (A2AR/D2R) heteromer formation was monitored in caudate from healthy and Parkinson’s disease (PD) subjects. The approach was first validated using striatal membranes from wild type and A2AR deficient mice. Secondly, we took advantage of the 6-hydroxydopamine hemiparkinsonian rat model to validate previous results. In addition, finally, A2AR/D2R heteromer formation was assessed in caudate membranes from human post-mortem brains. Importantly, our preliminary results revealed an increase in A2AR/D2R heteromer formation in PD brains. Conclusions: The new AlphaScreen assay allowed assessing GPCR heteromers in human post-mortem brains with high sensitivity.
The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
Authors: Rudzińska Magdalena , Parodi Alessandro , Soond Surinder M. , Vinarov Andrey Z. , Korolev Dmitry O. , Morozov Andrey O. , Daglioglu Cenk , Tutar Yusuf , Zamyatnin Andrey A.
Published: July 2019

Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology.
Carbon Nanomaterials and LED Irradiation as Antibacterial Strategies against Gram-Positive Multidrug-Resistant Pathogens
Authors: Elias Lisa , Taengua Rafael , Frígols Belén , Salesa Beatriz , Serrano-Aroca Ángel
Published: July 2019

Background: Due to current antibiotic resistance worldwide, there is an urgent need to find new alternative antibacterial approaches capable of dealing with multidrug-resistant pathogens. Most recent studies have demonstrated the antibacterial activity and non-cytotoxicity of carbon nanomaterials such as graphene oxide (GO) and carbon nanofibers (CNFs). On the other hand, light-emitting diodes (LEDs) have shown great potential in a wide range of biomedical applications. Methods: We investigated a nanotechnological strategy consisting of GO or CNFs combined with light-emitting diod (LED) irradiation as novel nanoweapons against two clinically relevant Gram-positive multidrug-resistant pathogens: methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE). The cytotoxicity of GO and CNFs was studied in the presence of human keratinocyte HaCaT cells. Results: GO or CNFs exhibited no cytotoxicity and high antibacterial activity in direct contact with MRSE and MRSA cells. Furthermore, when GO or CNFs were illuminated with LED light, the MRSE and MRSA cells lost viability. The rate of decrease in colony forming units from 0 to 3 h, measured per mL, increased to 98.5 ± 1.6% and 95.8 ± 1.4% for GO and 99.5 ± 0.6% and 99.7 ± 0.2% for CNFs. Conclusions: This combined antimicrobial approach opens up many biomedical research opportunities and provides an enhanced strategy for the prevention and treatment of Gram-positive multidrug-resistant infections.
Intragenic Antimicrobial Peptide Hs02 Hampers the Proliferation of Single- and Dual-Species Biofilms of P. aeruginosa and S. aureus: A Promising Agent for Mitigation of Biofilm-Associated Infections
Authors: Bessa Lucinda J. , Manickchand Julia R. , Eaton Peter , Leite José Roberto S. A. , Brand Guilherme D. , Gameiro Paula
Published: July 2019

Pseudomonas aeruginosa and Staphylococcus aureus are two major pathogens involved in a large variety of infections. Their co-occurrence in the same site of infection has been frequently reported and is linked to enhanced virulence and difficulty of treatment. Herein, the antimicrobial and antibiofilm activities of an intragenic antimicrobial peptide (IAP), named Hs02, which was uncovered from the human unconventional myosin 1H protein, were investigated against several P. aeruginosa and S. aureus strains, including multidrug-resistant (MDR) isolates. The antibiofilm activity was evaluated on single- and dual-species biofilms of P. aeruginosa and S. aureus. Moreover, the effect of peptide Hs02 on the membrane fluidity of the strains was assessed through Laurdan generalized polarization (GP). Minimum inhibitory concentration (MIC) values of peptide Hs02 ranged from 2 to 16 μg/mL against all strains and MDR isolates. Though Hs02 was not able to hamper biofilm formation by some strains at sub-MIC values, it clearly affected 24 h preformed biofilms, especially by reducing the viability of the bacterial cells within the single- and dual-species biofilms, as shown by confocal laser scanning microscopy (CLSM) and atomic force microscopy (AFM) images. Laurdan GP values showed that Hs02 induces membrane rigidification in both P. aeruginosa and S. aureus. Peptide Hs02 can potentially be a lead for further improvement as an antibiofilm agent.
Infusing Mesenchymal Stromal Cells into Porcine Kidneys during Normothermic Machine Perfusion: Intact MSCs Can Be Traced and Localised to Glomeruli
Authors: Pool Merel , Eertman Tim , Sierra Parraga Jesus , ’t Hart Nils , Roemeling-van Rhijn Marieke , Eijken Marco , Jespersen Bente , Reinders Marlies , Hoogduijn Martin , Ploeg Rutger , Leuvenink Henri , Moers Cyril
Published: July 2019

Normothermic machine perfusion (NMP) of kidneys offers the opportunity to perform active interventions, such as the addition of mesenchymal stromal cells (MSCs), to an isolated organ prior to transplantation. The purpose of this study was to determine whether administering MSCs to kidneys during NMP is feasible, what the effect of NMP is on MSCs and whether intact MSCs are retained in the kidney and to which structures they home. Viable porcine kidneys were obtained from a slaughterhouse. Kidneys were machine perfused during 7 h at 37 °C. After 1 h of perfusion either 0, 105, 106 or 107 human adipose tissue derived MSCs were added. Additional ex vivo perfusions were conducted with fluorescent pre-labelled bone-marrow derived MSCs to assess localisation and survival of MSCs during NMP. After NMP, intact MSCs were detected by immunohistochemistry in the lumen of glomerular capillaries, but only in the 107 MSC group. The experiments with fluorescent pre-labelled MSCs showed that only a minority of glomeruli were positive for infused MSCs and most of these glomeruli contained multiple MSCs. Flow cytometry showed that the number of infused MSCs in the perfusion circuit steeply declined during NMP to approximately 10%. In conclusion, the number of circulating MSCs in the perfusate decreases rapidly in time and after NMP only a small portion of the MSCs are intact and these appear to be clustered in a minority of glomeruli.
Mg/Al LDH Enhances Sulfate removal and Clarification of AMD Wastewater in Precipitation Processes
Authors: Maziarz Paulina , Matusik Jakub , Leiviskä Tiina
Published: July 2019

The sulfate removal from acid mine drainage (AMD) water (initial concentration: 5301 mg/L) was investigated by precipitation and/or adsorption using calcium hydroxide (Ca(OH)2) and synthetic layered double hydroxide (LDH) of the Mg/Al type. The exclusive use of LDH efficiently removed sulfates (64.2% reduction); however, alteration of its structure was observed due to low pH. The use of Ca(OH)2 in different doses calculated in relation to gypsum stoichiometry allowed to achieve an 86% removal of sulfates. Depending on the equilibrium pH, gypsum or ettringite were the main identified phases. The two-step removal, involving the use of Ca(OH)2 followed by LDH, was less efficient than the use of the Ca(OH)2/LDH mixture when the stoichiometric amount of Ca(OH)2 in relation to gypsum was applied. The application of mixture resulted in a fast pH increase, which prevented destruction of the LDH structure. Most importantly, the use of mixture significantly reduced the sludge volume and enhanced its settling velocity.
Replacing Di(2-ethylhexyl) Terephthalate by Di(2-ethylhexyl) 2,5-Furandicarboxylate for PVC Plasticization: Synthesis, Materials Preparation and Characterization
Authors: Matos Marina , Cordeiro Rosemeyre A. , Faneca Henrique , Coelho Jorge F. J. , Silvestre Armando J. D. , Sousa Andreia F.
Published: July 2019

The worldwide regulatory demand for the elimination of non-phthalate compounds for poly(vinyl chloride) (PVC) plasticization has intensified the search for alternatives. Concomitantly, sustainability concerns have highlighted sugar-based 2,5-furandicarboxylic acid as one key renewable-chemical for the development of several products, namely di(2-ethylhexyl) 2,5-furandicarboxylate (DEHF) plasticizer. This study addresses the use of DEHF under a realistic scenario of the co-existence of both DEHF and entirely fossil-based plasticizers. More precisely, original PVC blends using mixtures of non-toxic DEHF and di(2-ethylhexyl) terephthalate ester (DEHT) were designed. The detailed structural, thermal, and mechanical characterization of these materials showed that they all have a set of interesting properties that are compatible with those of commercial DEHT, namely a low glass transition (19.2–23.8 °C) and enhanced elongation at break (up to 330%). Importantly, migration tests under different daily situations, such as for example exudation from food/beverages packages and medical blood bags, reveal very low weight loss percentages. For example, in both distilled water and phosphate buffered saline (PBS) solution, weight loss does not exceed ca. 0.3% and 0.2%, respectively. Viability tests show, for the first time, that up to 500 μM of DEHF, a promising cytotoxic profile is observed, as well as for DEHT. Overall, this study demonstrates that the combination of DEHF and DEHT plasticizers result in a noticeable plasticized PVC with an increased green content with promising cytotoxic results.
Enhanced Refinement of Al-Zn-Mg-Cu-Zr Alloy via Internal Cooling with Annular Electromagnetic Stirring above the Liquidus Temperature
Authors: Guan Tianyang , Zhang Zhifeng , Bai Yuelong , Li Bao , Wang Ping
Published: July 2019

There are two critical stages of grain refinement during solidification: above and below the liquidus temperature. The key to improve the refinement potential is ensuring the nucleation sites precipitate in large quantities and dispersed in the melt above liquidus. In this work, internal cooling with annular electromagnetic stirring was applied to an Al-Zn-Mg-Cu-Zr alloy at a temperature above liquidus. A systematic experimental study on the grain refining potential was performed by combining different melt treatments and pouring temperatures. The results indicate that internal cooling with annular electromagnetic stirring (IC-AEMS) had a significantly superior grain refining potency for the alloy compared to traditional electromagnetic stirring (EMS). In addition, homogeneous and refined grains were achieved at high pouring temperatures with IC-AEMS. The possible mechanisms for the enhanced grain refinement above the liquidus temperature are explained as the stable chilling layer around the cooling rod in IC-AEMS providing undercooling for the precipitation of Al3Zr nucleant particles and the high cooling rate restraining the growth rate of these particles. At the same time, forced convection promotes a more homogeneous distribution of nucleant particles.
Prostaglandins in Marine Organisms: A Review
Authors: Di Costanzo Federica , Di Dato Valeria , Ianora Adrianna , Romano Giovanna
Published: July 2019

Prostaglandins (PGs) are lipid mediators belonging to the eicosanoid family. PGs were first discovered in mammals where they are key players in a great variety of physiological and pathological processes, for instance muscle and blood vessel tone regulation, inflammation, signaling, hemostasis, reproduction, and sleep-wake regulation. These molecules have successively been discovered in lower organisms, including marine invertebrates in which they play similar roles to those in mammals, being involved in the control of oogenesis and spermatogenesis, ion transport, and defense. Prostaglandins have also been found in some marine macroalgae of the genera Gracilaria and Laminaria and very recently the PGs pathway has been identified for the first time in some species of marine microalgae. In this review we report on the occurrence of prostaglandins in the marine environment and discuss the anti-inflammatory role of these molecules.
Syntheses of Benzo[d]Thiazol-2(3H)-One Derivatives and Their Antidepressant and Anticonvulsant Effects
Authors: Jin Qinghao , Fu Zhiyang , Guan Liping , Jiang Haiying
Published: July 2019

Thirty-four new benzo[d]thiazol derivatives 2a–2i, 3a–3r, and 4a–4g were synthesized and investigated for their potential antidepressant and anticonvulsant effects. In a forced swimming test, 2c and 2d showed the highest antidepressant and anticonvulsant effects. 2c and 2d displayed a higher percentage decrease in immobility duration (89.96% and 89.62%, respectively) than that of fluoxetine (83.62%). In the maximal electroshock seizure test, 3n and 3q showed the highest anticonvulsant effect, with ED50 values of 46.1 and 64.3 mg kg−1, and protective indices of 6.34 and 4.11, respectively, which were similar to those of phenobarbital or valproate. We also found that the mechanism for the antidepressant activity of 2c and 2d may be via increasing the concentrations of serotonin and norepinephrine.
Combination of Healthy Lifestyle Factors on the Risk of Hypertension in a Large Cohort of French Adults
Authors: Lelong Helene , Blacher Jacques , Baudry Julia , Adriouch Solia , Galan Pilar , Fezeu Leopold , Hercberg Serge , Kesse-Guyot Emmanuelle
Published: July 2019

Background: Healthy lifestyle factors are widely recommended for hypertension prevention and control. Nevertheless, little is known about their combined impact on hypertension, in the general population. Our aim was to compute a Healthy Lifestyle Index (HLI) comprising the main non-pharmacological measures usually recommended to improve hypertension prevention: normal weight, regular physical activity, limited alcohol consumption, adoption of a healthy diet; to evaluate their combined impact on hypertension incidence. Methods: We prospectively followed the incidence of hypertension among 80,426 French adults participating in the NutriNet-Santé cohort study. Self-reported dietary, socio-demographic, lifestyle and health data were assessed at baseline and yearly using a dedicated website; the association between HLI and hypertension risk was assessed by multivariable Cox proportional hazards models adjusted for age, sex, family history of hypertension, socio-demographic and lifestyle factors. Hypothetical Population Attributable Risks associated to each factor were estimated. Results: During a median follow-up of 3.5 years (IQR: 1.5–5.3), 2413 incident cases of hypertension were identified. Compared with no or one healthy lifestyle factor, the hazard ratios (HR) for hypertension were 0.76 (95% CI, 0.67–0.85) for two factors, 0.47 (95% CI, 0.42–0.53) for three factors and 0.35 (95% CI, 0.30–0.41) for all healthy lifestyle factors (p-trend <0.0001). Compared with adhering to 0, 1, 2 or 3 healthy lifestyles, adhering to all of them was found associated with a reduction of the hypertension risk of half (HR = 0.55 (95% CI, 0.46–0.65)). Conclusion: Active promotion of healthy lifestyle factors at population level is a key leverage to fight the hypertension epidemic.
Nutrient Content of Squeeze Pouch Foods for Infants and Toddlers Sold in the United States in 2015
Authors: Beauregard Jennifer L. , Bates Marlana , Cogswell Mary E. , Nelson Jennifer M. , Hamner Heather C.
Published: July 2019

Background: To describe the availability and nutrient composition of U.S. commercially available squeeze pouch infant and toddler foods in 2015. Materials and Methods: Data were from information presented on nutrition labels for 703 ready-to-serve, pureed food products from 24 major U.S. infant and toddler food brands. We described nutritional components (e.g., calories, fat) and compared them between packaging types (squeeze pouch versus other packaging types) within food categories. Results: 397 (56%) of the analyzed food products were packaged as squeeze pouches. Differences in 13 nutritional components between squeeze pouch versus other packaging types were generally small and varied by food category. Squeeze pouches in the fruits and vegetables, fruit-based, and vegetable-based categories were more likely to contain added sugars than other package types. Conclusion: In 2015, squeeze pouches were prevalent in the U.S. commercial infant and toddler food market. Nutrient composition differed between squeeze pouches and other packaging types for some macro- and micronutrients. Although it is recommended that infants and toddlers under two years old not consume any added sugars, a specific area of concern may be the inclusion of sources of added sugar in squeeze pouches. Linking this information with children’s dietary intake would facilitate understanding how these differences affect overall diet quality.
Immediate and 15-Week Correlates of Individual Commitment to a “Green Monday” National Campaign Fostering Weekly Substitution of Meat and Fish by Other Nutrients
Authors: Bègue Laurent , Treich Nicolas
Published: July 2019

Promoting healthier and more sustainable diets by decreasing meat consumption represents a significant challenge in the Anthropocene epoch. However, data are scarce regarding the effects of nationwide meat reduction campaigns. We described and analyzed the correlates of a national campaign in France (called “Green Monday”, GM) promoting the weekly substitution of meat and fish by other nutrients. Two cross-sectional online surveys were compared: a National Comparison sample (NC) of the French general population and a self-selected sample of participants who registered for the Green Monday campaign. A follow-up study was carried out in the GM sample, in which participants were asked during 15 weeks whether or not they had substituted meat and fish. There were 2005 participants aged 18–95 (47.7% females) in the NC sample and 24,507 participants aged 18–95 (77.5% females) in the GM sample. One month after the beginning of the campaign, 51.2% of the respondents reported they had heard about Green Monday in the NC sample, and 10.5% indicated they had already started to apply Green Monday. Logistic regression analysis showed that compared to the NC sample, participants belonging to the GM sample displayed a higher rate of females, Odds Ratio (OR) = 4.26, 95% Confidence Interval (CI): 3.86–4.71, were more educated, OR = 1.32, 95% CI: 1.28–1.36, had higher self-rated affluence, OR = 1.50, 95% CI: 1.42–1.58 and the size of their vegetarian network was greater, OR = 1.50, 95% CI: 1.41–1.58. They reported a slightly higher frequency of meat consumption, OR = 1.05, 95% CI: 1.01–1.10, while their frequency of fish consumption was lower, OR = 0.81, 95% CI: 0.76–0.87. Finally, the personality dimension Openness was more strongly endorsed by participants in the GM sample, OR = 1.79, 95% CI: 1.65–1.93. A multiple regression analysis indicated that Openness also predicted the number of participation weeks in the GM Sample (beta = 0.03, p < 0.009). In conclusion, specific demographic and personality profiles were more responsive to the national campaign, which could inform and help to shape future actions aiming at changing food habits.
Enhanced 3-D GM-MAC Protocol for Guaranteeing Stability and Energy Efficiency of IoT Mobile Sensor Networks
Authors: Jang Yoonkyung , Shin Ahreum , Ryoo Intae
Published: July 2019

In wireless sensor networks, energy efficiency is important because sensor nodes have limited energy. 3-dimensional group management medium access control (3-D GM-MAC) is an attractive MAC protocol for application to the Internet of Things (IoT) environment with various sensors. 3-D GM-MAC outperforms the existing MAC schemes in terms of energy efficiency, but has some stability issues. In this paper, methods that improve the stability and transmission performance of 3-D GM-MAC are proposed. A buffer management scheme for sensor nodes is newly proposed. Fixed sensor nodes that have a higher priority than the mobile sensor nodes in determining the group numbers that were added, and an advanced group number management scheme was introduced. The proposed methods were simulated and analyzed. The newly derived buffer threshold had a similar energy efficiency to the original 3-D GM-MAC, but improved performance in the aspects of data loss rate and data collection rate. Data delay was not included in the comparison factors as 3-D GM-MAC targets non-real-time applications. When using fixed sensor nodes, the number of group number resets is reduced by about 43.4% and energy efficiency increased by about 10%. Advanced group number management improved energy efficiency by about 23.4%. In addition, the advanced group number management with periodical group number resets of the entire sensor nodes showed about a 48.9% improvement in energy efficiency.
Optimal Offloading Decision Strategies and Their Influence Analysis of Mobile Edge Computing
Authors: Xu Jiuyun , Hao Zhuangyuan , Sun Xiaoting
Published: July 2019

Mobile edge computing (MEC) has become more popular both in academia and industry. Currently, with the help of edge servers and cloud servers, it is one of the substantial technologies to overcome the latency between cloud server and wireless device, computation capability and storage shortage of wireless devices. In mobile edge computing, wireless devices take responsibility with input data. At the same time, edge servers and cloud servers take charge of computation and storage. However, until now, how to balance the power consumption of edge devices and time delay has not been well addressed in mobile edge computing. In this paper, we focus on strategies of the task offloading decision and the influence analysis of offloading decisions on different environments. Firstly, we propose a system model considering both energy consumption and time delay and formulate it into an optimization problem. Then, we employ two algorithms—Enumerating and Branch-and-Bound—to get the optimal or near-optimal decision for minimizing the system cost including the time delay and energy consumption. Furthermore, we compare the performance between two algorithms and draw the conclusion that the comprehensive performance of Branch-and-Bound algorithm is better than that of the other. Finally, we analyse the influence factors of optimal offloading decisions and the minimum cost in detail by changing key parameters.
Influence of Volumetric Damage Parameters on Patch Antenna Sensor-Based Damage Detection of Metallic Structure
Authors: Liu Zhiping , Yu Hanjin , Zhou Kai , Li Runfa , Guo Qian
Published: July 2019

Antenna sensors have been employed for crack monitoring of metallic materials. Existing studies have mainly focused on the mathematical relationship between the surface crack length of metallic material and the resonant frequency. The influence of the crack depth on the sensor output and the difference of whether the crack is depth-penetrated remains unexplored. Therefore, in this work, a numerical simulation method was used to investigate the current density distribution characteristics of the ground plane (metallic material) with different crack geometric parameters. The data reveals that, compared with the crack length, the crack depth has a greater influence on the resonant frequency. The relationship between the frequency and the crack geometric parameters was discussed by characterizing the current density and sensor output under different crack lengths and depths. Therefore, the feasibility of monitoring another common damage of metallic materials, i.e., corrosion pit, was explored. Furthermore, the influences of crack and corrosion pit geometric parameters on the output results were validated by experiments.
A Device-Free Indoor Localization Method Using CSI with Wi-Fi Signals
Authors: Dang Xiaochao , Tang Xuhao , Hao Zhanjun , Liu Yang
Published: July 2019

Amid the ever-accelerated development of wireless communication technology, we have become increasingly demanding for location-based service; thus, passive indoor positioning has gained widespread attention. Channel State Information (CSI), as it can provide more detailed and fine-grained information, has been followed by researchers. Existing indoor positioning methods, however, are vulnerable to the environment and thus fail to fully reflect all the position features, due to limited accuracy of the fingerprint. As a solution, a CSI-based passive indoor positioning method was proposed, Wavelet Domain Denoising (WDD) was adopted to deal with the collected CSI amplitude, and the CSI phase information was unwound and transformed linearly in the offline phase. The post-processed amplitude and phase were taken as fingerprint data to build a fingerprint database, correlating with reference point position information. Results of experimental data analyzed under two different environments show that the present method boasts lower positioning error and higher stability than similar methods and can offer decimeter-level positioning accuracy.
A Comparable Study of CNN-Based Single Image Super-Resolution for Space-Based Imaging Sensors
Authors: Zhang Haopeng , Wang Pengrui , Zhang Cong , Jiang Zhiguo
Published: July 2019

In the case of space-based space surveillance (SBSS), images of the target space objects captured by space-based imaging sensors usually suffer from low spatial resolution due to the extremely long distance between the target and the imaging sensor. Image super-resolution is an effective data processing operation to get informative high resolution images. In this paper, we comparably study four recent popular models for single image super-resolution based on convolutional neural networks (CNNs) with the purpose of space applications. We specially fine-tune the super-resolution models designed for natural images using simulated images of space objects, and test the performance of different CNN-based models in different conditions that are mainly considered for SBSS. Experimental results show the advantages and drawbacks of these models, which could be helpful for the choice of proper CNN-based super-resolution method to deal with image data of space objects.
Low Power Wide Area Networks (LPWAN) at Sea: Performance Analysis of Offshore Data Transmission by Means of LoRaWAN Connectivity for Marine Monitoring Applications
Authors: Parri Lorenzo , Parrino Stefano , Peruzzi Giacomo , Pozzebon Alessandro
Published: July 2019

In this paper the authors discuss the realization of a Long Range Wide Area Network (LoRaWAN) network infrastructure to be employed for monitoring activities within the marine environment. In particular, transmission ranges as well as the assessment of parameters like Signal to Noise Ratio (SNR) and Received Signal Strength Indicator (RSSI) are analyzed in the specific context of an aquaculture industrial plant, setting up a transmission channel from an offshore monitoring structure provided with a LoRaWAN transmitter, to an ashore receiving device composed of two LoRaWAN Gateways. A theoretical analysis about the feasibility of the transmission is provided. The performances of the system are then measured with different network parameters (in particular the Spreading Factor—SF) as well as with two different heights for the transmitting antenna. Test results prove that efficient data transmission can be achieved at a distance of 8.33 km even using worst case network settings: this suggests the effectiveness of the system even in harsher environmental conditions, thus entailing a lower quality of the transmission channel, or for larger transmission ranges.
Correction: Design and Simulation of a Wireless SAW–Pirani Sensor with Extended Range and Sensitivity
Authors: Toto Sofia , Nicolay Pascal , Morini Gian Luca , Rapp Michael , Korvink Jan G. , Brandner Juergen J.
Published: July 2019

The authors wish to make the following erratum to Reference [...]
Feasibility Study on Temperature Distribution Measurement Method of Thrust Sliding Bearing Bush Based on FBG Quasi-Distributed Sensing
Authors: Liu Hu , Yu Qiang , Tan Yuegang , Xu Wenjun , Huang Bing , Xie Zhichao , Mao Jian
Published: July 2019

According to the characteristics of the temperature distribution of the thrust sliding bearing bush, the principle and method of quasi-distributed fiber Bragg grating (FBG) sensing is used to measure it. The key problems such as calibration, arrangement and lying of optical FBG sensors are studied by using the simulated thrust sliding bearing bush, which was customized in the laboratory. Combined with the thrust sliding bearing bush, the measurement experiments were carried out, which were divided into two groups: Steady-state experiments and transient experiment. The steady-state experiments obtain the temperature data measured by the FBG temperature sensors at each setting temperature, and the transient experiment obtains the relationship between the measured temperature by each temperature sensor and time in the heating and cooling process. The experimental results showed that the FBG temperature sensors had good accuracy, stability and consistency when measuring the temperature distribution of bearing bush.
Does the Low-Carbon Pilot Initiative Reduce Carbon Emissions? Evidence from the Application of the Synthetic Control Method in Guangdong Province
Authors: Yu Xuan , Shen Manhong , Wang Di , Imwa Bernadette Tadala
Published: July 2019

As the world’s top energy consumer and carbon emitter, China’s carbon emissions policies, including the low-carbon pilot initiative (LCPI) implemented in July 2010, have important effects on global climate change. Therefore, accurately assessing the effect of this policy has become extremely important for low-carbon development. This article analyses the impact of implementing LCPI on regional carbon emissions by using Guangdong Province as the study area, which has the largest economic scale, population size and carbon emissions amongst China’s low-carbon pilot provinces. The results suggest that for the entire 2010–2015 period, Guangdong’s carbon emissions were reduced by about 10% due to the implementation of LCPI. This policy produced a significant impact on the carbon emissions from manufacturing industries but showed minimal impact on the carbon emissions from energy production. Unlike previous researchers who relied on estimations, the authors of this work obtained unified carbon emissions data for 1997–2015 from the China Emission Accounts and Datasets and then constructed comparison groups by using the synthetic control method instead of performing a subjective selection. The authors also examined the impact of LCPI on carbon emissions from different sources. This article proposes that policy support and low-carbon action are necessary for reducing regional carbon emissions and that the policies must be constantly adjusted during their implementation. The successful experiences in low-carbon pilots are also worth exploring and promoting in other regions.
Are Sustainable Development Policies Really Feasible? Focused on the Petrochemical Industry in Korea
Authors: Choi Yongrok , Lee Hyoung Seok , Mastur Ahmed
Published: July 2019

Korea inaugurated an emission trading scheme (ETS) in 2015 for its ambitious target to reduce 37% greenhouse gas per 2030 business-as-usual level. This study examines the sustainable governance of the Korean petrochemical industry, one of the world’s major emitters of greenhouse gas, with 55 firms participating in ETS. On the basis of the non-radial, non-parametric directional distance function, this study derives three types of efficiencies: greenhouse gas technical efficiency (GTE), pure technical efficiency, and scale efficiency. Using these indices, this study also provides information for benchmarking for the fast followers. The findings of this study reveal the following. First, petrochemical industry exhibits 63.5% ETS performance, on average, showing huge potential improvement. Second, by decomposing GTE value, this study provides information from the perspective of scale to find out the oversupply issues in some petrochemical firms. Lastly, benchmark information for each firm is provided to enhance its efficiency.
Perceived Quality in Sports Centers in Southern Spain: A Case Study
Authors: Castillo-Rodriguez Alfonso , Onetti-Onetti Wanesa , Chinchilla-Minguet José Luis
Published: July 2019

The aim of this study was to analyze the level of satisfaction in three municipal sports centers in the city of Malaga and to learn and analyze the characteristics of users older than 40 years of age in these centers. A total of 303 persons (123 men and 180 women) from three sports centers in the city of Malaga participated in this study (M = 58.14, SD = 7.16 years). The Evaluation of Perceived Quality in Sports Services test (CECASDEP) was used, and the results demonstrated that the different dimensions studied—sports center, activity space, locker rooms, program of activities, and trainer—were very positively correlated. The level of customer loyalty increased with user satisfaction and perceived quality of services as well as the age of the person. Users were also found to be more motivated to take part in physical activities due to greater satisfaction. The highest scores were given to the trainers, who played a key role in all three sports centers. In conclusion, we gathered important insights into perceived quality in different sports centers. This information can be used by sports managers to strengthen dimensions with lower scores and improve those with higher scores. In addition, the study confirms that the level of customer loyalty is related to the perceived quality scores. Therefore, the use of measuring instruments is recommended to optimize the quality of sports services.
Interactive Buildings: A Review
Authors: Fallahi Zahra , Henze Gregor
Published: July 2019

Buildings are widely regarded as potential sources for demand flexibility. The flexibility of thermal and electric load in buildings is a result of their interactive nature and its impact on the building’s performance. In this paper, the interaction of a building with the three interaction counterparts of the physical environment, civil infrastructure networks and other buildings is investigated. The literature review presents a wide variety of pathways of interaction and their associated potential impacts on building performance metrics such as net energy use, emissions, occupant comfort and operational cost. It is demonstrated that all of these counterparts of interaction should be considered to harness the flexibility potential of the buildings while maintaining other buildings performance metrics at a desired level. Juxtaposed with the upside potential for providing demand flexibility, numerous implementation challenges are identified that are associated with the evaluation and financial valuation of the capacity for demand flexibility, the aggregated flexibility potential, as well as the control and communication to facilitate the interactions.
Metastatic Cardiac Hemangiosarcoma in a 6 Year Old Wheaten Terrier Mix
Authors: Arai Shiori , Milley Ellen P , Lichtenberger Jonathan , Savidge Christine , Lawrence Jessica , Côté Etienne
Published: July 2019

A 6 year old Wheaten Terrier mix with a history of collapse and lethargy was referred for evaluation of pericardial effusion. The echocardiogram identified pericardial effusion and a right auricular mass. No sign of metastasis was noted at this time in thoracic radiographs and abdominal ultrasounds. The patient underwent the right auriculectomy via right lateral thoracotomy. Several metastatic masses were located in the visceral aspect of the pericardium at the time of surgery and were all excised. The right auricular mass and pericardial masses were diagnosed as hemangiosarcoma with a sign of metastasis. The patient recovered from surgery uneventfully and was discharged the sixth day after surgery. The patient received doxorubicin followed by cyclophosphamide, piroxicam and Coriolus versicolor extract postoperatively. Pulmonary metastases were noted 229 days and the dog was euthanized 318 days after surgery. No clinical signs were noted until 309 days postoperatively.