bluuebunny/crossref_metadata_2025 huggingface dataset:
Segurança alimentar e PNAE
Authors: Salgado Bárbara Teles , DelGrossi Mauro Eduardo
Published: August 2022

O tema da insegurança alimentar voltou ao debate na sociedade durante a pandemia de Covid-19. O PNAE é um importante instrumento para promover os direitos relacionados à alimentação, além de contribuir para o fortalecimento da economia local e gerar renda aos agricultores familiares. Este artigo tem como objetivo realizar uma análise qualitativa sobre a execução do PNAE no Município de São João d’Aliança – GO, especialmente sobre sua contribuição para a agricultura familiar local e os impactos e alternativas adotadas no período de suspensão das atividades escolares no período da pandemia de Covid-19. Para alcançar o objetivo pretendido foi empregado o estudo de caso por meio de uma abordagem qualitativa, também foram empregadas as técnicas de revisão de literatura, entrevista semiestruturada e a observação,  garantindo assim a triangulação dos dados obtidos e uma maior confiabilidade na pesquisa. No período anterior ao da pandemia, o município ultrapassava a quantidade mínima de aquisições da agricultura familiar (30%), especialmente devido à articulação entre os agentes públicos locais com a cooperativa local de agricultores. No período da pandemia, esta articulação teve continuidade com a distribuição de kits alimentares para famílias em situação de insegurança alimentar, superando desafios e inaugurando novas possibilidades.
FACTORS RELATED TO COMPLAINTS OF CONTACT DERMATITIS AMONG MOTORCYCLE MECHANICS IN THE SOUTH AND NORTH KEMBANGAN AREAS, JAKARTA IN 2021
Authors: Maula Monica Sofia , Rusdy Mirta Dwi Rahmah , Handayani Putri , Muda Cut Alia Keumala
Published: August 2022

Background: Occupational contact dermatitis is an inflammation of the skin caused by materials found in the work environment. Purpose: To determine the factors associated with Complaints of Occupational Contact Dermatitis among Motorcycle Workshop Workers in the Kelurahan Kembangan Selatan and Kembangan Utara, Jakarta in 2021. Method: This research is a descriptive-analytic study with a cross-sectional study design. The population of this research is motorcycle repair workers in the southern and northern Kembangan villages amounted 78 workers. The sample in this study amounted to 35 samples of workshop workers with Quota sampling technique. The method of collecting data from the source of information used is in the form of primary data using measuring instruments in the form of questionnaires and observation sheets. Result: The proportion of workers who complained of work-related contact dermatitis were 13 workshop workers (37.1%). Conclusion: Based on the results of statistical tests, it is known that the variable associated with occupational contact dermatitis is the age (p-value 0.004) and working period (p-value 0.005) with complaints of occupational contact dermatitis in motorcycle repair workers in the Kembangan Selatan and Kembangan Utara sub-districts, meanwhile not related between length of contact (p-value 0.282), personal hygiene (p-value 0.689) and the use of PPE (p-value 0.519) with complaints of occupational contact dermatitis in motorcycle repair workers in the Kembangan Selatan and Kembangan Utara areas, Jakarta.
IMPLEMENTATION NUTRIGENOMIC OF VITAMIN D IN PERIODONTITIS
Authors: Hervina Hervina , Sukrama I Dewa Made , Jawi I Made
Published: August 2022

Background: Nutrition is a significant risk factor for the incidence of periodontal disease. Nutrients acting on the human genome, either directly or indirectly, can change the expression and structure of genes. One of the micronutrients associated with periodontitis is vitamin D. Vitamin D has an important role in bone and calcium metabolism and regulates serum calcium and phosphate concentrations at normal limits. Purpose: To discuss the nutritional vitamin D as an essential micronutrient in preventing and accelerating healing in periodontitis. Review: Searched two databases from article publication to April 2021, resulting in a total of 66 hits, from which seven relevant articles were selected. VDR signaling can build transcription of genes encoding proactive cytokines, bypassing the cyclo-oxygenase-2 (COX-2) and prostaglandin pathway, and can inhibit matrix metalloproteinase production. The protective mechanism of vitamin D against periodontitis occurs through two biological pathways, namely anti-microbial and anti-inflammatory pathways. The anti-microbial effect of vitamin D results from the binding of 1,25(OH)2D3 with VDR which then induces cAMP, b-def-2 and b-def-3 peptides by macrophages, monocytes, gingival epithelium and periodontal ligament epithelium. The anti-inflammatory effect occurs through decreased production of proinflammatory cytokines. Conclusion: All the signaling effects of VDR can reduce bacteria induced in the inflammatory cytokines so that personalized vitamin D supplementation with an adjusted dose as needed can be used in preventing periodontitis or accelerating the healing of periodontitis.
Regenerative Therapy for Chronic Heart Failure: Prospects for the Use of Cellular and Acellular Technologies
Authors: Dolgopolov I. S. , Rykov M. Yu. , Osadchij V. V.
Published: August 2022

Cardiovascular diseases are the second leading cause of death and disability worldwide after malignancies. Heart failure (HF) has a large impact not only on the economics of healthcare but also on the quality of life, functionality and life expectancy of patients. Pharmacological and non-pharmacological therapies have been developed, but these medical therapies have limited effects to cure patients with severe CH. Heart transplantation is limited due to the low number of donor organs. Human cardiac potential for spontaneous repair is insignificant, so regenerative therapy is in great demand as a new treatment strategy. Currently, there are several strategies for heart regeneration. Transplantation of somatic stem cells was safe and modestly improved cardiac function after myocardial infarction and in patients with CF mainly through paracrine mechanisms. Alternatively, new cardiomyocytes could be generated from induced pluripotent stem cells (iPSCs) to transplant into injured hearts. However, several issues remain to be resolved prior to using iPSC-derived cardiomyocytes, such as a potential risk of tumorigenesis and poor survival of transplanted cells in the injured heart. Recently, direct cardiac cell-free reprogramming has emerged as a novel technology to regenerate damaged myocardium by directly converting endogenous cardiac fibroblasts into induced cardiomyocyte-like cells to restore cardiac function. Many researchers have reported direct reprogramming of the heart in vivo in animal and human cells. In this review, we review the current status of cardiac cell-based and cell-free regenerative technology, a great hope to treat cardiovascular diseases in clinical practice.
Symptoms in the Long Period after the Coronavirus Infection: Results of Long-Term Follow-Up
Authors: Melekhov A. V. , Agaeva A. I. , Nikitin I. G.
Published: August 2022

Background: assessment of type, prevalence and duration of residual symptoms after COVID-19 in recent studies is controversial because of differences in design. Aim: to assess the prevalence and severity of symptoms in the long-term period after COVID-19. Materials and methods: patients hospitalized with COVID-19 in the period 13.04.2020-10.06.2020 were interviewed by phone: 195 (58,2 %) convalescents at 143 (131-154) days after disease onset and 183 (54,6 % ) of them at 340 (325-351) days. Results: The subjective assessment of health status with 100-point scale before and after the COVID-19 was 95 (80-100) and 80 (70-96) points, p< 0,001, at first interview; 90 (80-100) and 80 (60-90) points, p< 0,001, at second one. Various complaints were detected in 63 % of respondents at the first interview and in 75 % at the second, the number of identified symptoms was 2 (0-6) and 4 (1-8) respectively. The most frequent complaints were weakness/fatigue (31.3 and 47.5 % of respondents), joint pain (31.3 and 47.5 %) and dyspnoe/shortness of breath (31.3 and 43.2 %). The growth of these indicators can be associated with a change in the interview methodology. The severity of the symptoms at second interview was low: fatigue — 3 (0-6) points, shortness of breath — 0 (0-3) points; joint pain, weakness and dyspnoe — 0 (0-5) points each. Conclusion: a decrease of health status can sustain for a long time after COVID-19. Symptoms persist in a significant proportion of convalescents, but their severity in the end of follow-up is quite low.
The Relationship of Neurocognitive Impairment and Quality of Life in Patients Diagnosed with Schizophrenia
Authors: HAJIYEVA Günay , ÇAKMAK Soner , TAMAM Lut , KARAYTUĞ Mahmut Onur , DEMİRKOL Mehmet Emin , NAMLI Zeynep , AKTAŞ Said
Published: August 2022

Bilişsel işlev bozukluğu şizofreninin temel bir özelliğidir. Bilişsel yürütücü işlevler dahil olmakla çeşitli alanlarda, farklı şiddetlerde kendini belli edebilir. Aynı zamanda nörobilişsel bozuklukların yaşam kalitesi üzerine de negatif etkileri mevcuttur. Çalışmamız şizofreni hastalarında nörobilişsel bozulmanın, hastalık süresi, yaşam kalitesi ve sosyodemografik özellikler ile ilişkisini araştırmayı amaçlamıştır. Çukurova Üniversitesi Tıp Fakültesi Balcalı Hastanesi Ruh Sağlığı ve Hastalıkları Anabilim Dalı’nda ayaktan ya da yatarak tedavi gören şizofrenik bozukluk tanısı almış 100 hasta bu çalışmanın örneklem grubunu oluşturmaktadır. Ayrıca genel toplumdan cinsiyet ve yaş olarak benzer 80 sağlıklı kişi kontrol grubu olarak çalışmaya dahil edilmiştir. Kontrol grubuna tarafımızca oluşturulan sosyodemografik veri formuna ek olarak Frontal Değerlendirme Bataryası (FDB), Dünya Sağlık Örgütü Yaşam Kalitesi Ölçeği Kısaltılmış Versiyonu (WHOQOL-BREF) ölçekleri hasta grubuna ise bu ölçeklere ek olarak Pozitif ve Negatif Sendrom Ölçeği (PANNS) uygulanmıştır. Hastalığının ilk 5 yılında olanlar ile 5 yıldan fazla süredir hasta olanların FDB puan ortalaması arasındaki fark istatiksel olarak anlamlı bulunmuştur (p=0,008). Hastaneye yatış sayısına göre yaşam kalitesi (p=0,001) ve FDB (p=0,02) ölçek puan ortalamaları arasında anlamlı fark bulunmuştur. Eğitim durumuna göre hasta grubunda yaşam kalitesi (p=0,001) ve FDB (p<0,001) ölçek puan ortalamaları arasında anlamlı fark bulunmuştur. Aile öyküsü olanlar ile olmayanların yaşam kalitesi (p=0,01) ve FDB (p=0,01) ölçek puan ortalamaları arasındaki fark anlamlı bulunmuştur. Çalışmamızın sonucuna göre hastalığın ilk beş yılında, eğitim düzeyi yüksek olanlarda, çalışanlarda nörobilişsel etkilenmeler daha az görülmüş olup, yaşam kalitesi daha yüksektir. Hastaneye yatış sayısı arttıkça bilişsel işlevlerde daha çok etkilenme görülmüştür. Hastalık süresi ve PANSS ölçek puanları yüksek olan hastalarda bilişsel işlevlerdeki bozulmanın daha fazla olduğu saptanmıştır. Hastalığın ilk yıllarında erken tanı, tedavi ve rehabilitasyon ile olguların eğitim hayatı ve istihdamlarında iyileşme sağlanarak daha kaliteli yaşam sürmeleri için sosyal destek çalışmaları yapılmalıdır.
Anti-Sitoplazmik ve Anti-Mitotik Otoantikorlar; Bu Antikorların Hastalıklarla İlişkisi Var Mı?
Authors: KAŞİFOĞLU Nilgün , YAŞAR BİLGE Nazife Şule , KAŞİFOĞLU Timuçin
Published: August 2022

Examination of antinuclear antibody (ANA) is used in diagnosis of systemic autoimmune diseases, and the indirect immunofluorescence (IIF) assay using HEp-2 cells is the gold standard method. HEp-2 allows the detection of multiple target antigen-directed autoantibodies. The guide “The International Consensus on ANA Patterns (ICAP)”, characterizes the patterns into three groups: nuclear, cytoplasmic, and mitotic. The majority of these are associated with autoimmune diseases, but some are rarely seen in autoimmune diseases or may be associated with conditions other than autoimmune disease. There is no consensus on how to report cytoplasmic and mitotic patterns-negative or positive. We aimed to examine the characteristics of patients that had cytoplasmic or mitotic staining in ANA evaluation by IIF. In our Medical Microbiology Laboratory, 18985 ANA tests of 16940 patients were studied between 01.01.2015-31.12.2019. Cytoplasmic or mitotic pattern was detected in 393 (2.07%) tests belonging to 385 patients. Cytoplasmic patterns suggestive of anti-mitochondrial antibody (AMA), anti-smooth muscle antibody (ASMA), anti-Jo-1 and anti-ribosomal P-protein were not included. The most common patterns were anti-midbody, anti-spindle fibers, and anti-vimentin patterns. There were 66 rheumatology patients that were negative for ANA but had cytoplasmic or mitotic staining. There was no statistically significant difference between the diagnosis and patterns of these patients. We suggest that the ANA should be reported as “negative” in case of cytoplasmic or mitotic pattern unless the term anti-cell antibody is used. It should be noted in the description part of the report in order to distinguish significant cytoplasmic patterns and give an idea for some specific conditions.
Implications of Auditors` Rotation in Financial Audit Reporting
Authors:   West University of Timisoara, Romania, BULUCEA Mariana , BUNGET Ovidiu Constantin ,   West University of Timisoara, Romania, DUMITRESCU Alin Constantin ,   West University of Timisoara, Romania, BURCA Valentin ,   West University of Timisoara, Romania, BOGDAN Oana ,   West University of Timisoara, Romania
Published: August 2022

The purpose of this paper is to study the implications of auditors' rotation on financial audit reporting in the case of companies listed on the Bucharest Stock Exchange in the period 2011-2021. It was analyzed the relationship between the rotation of audit firms and the audit opinion, the impact on the audit cost, as well as the effects on the key audit matters. The regulatory framework has been modified at the same time for the key audit matters and the rotation of auditors, and it is therefore interesting to examine how they associate with each other. Using the descriptive statistical analysis method mainly oriented towards graphical analysis, it is illustrated that the rotation of audit firms leads to improved reporting in audit by reducing the number of modified opinions, respectively increasing the number of KAM communicated in the audit report. Finally, the change of auditor does not lead to substantial changes in the audit fees, which is why such a decision is not determined by considerations of reduction of audit costs, but rather by other reasons.
Whole-vine resources modify within-vine relationships between growth parameters and metabolites in Vitis vinifera L. cv. Cabernet-Sauvignon
Authors: Wisdom Joanne Margaret Bennett , Considine John Anthony
Published: August 2022

Fruit ripening on a perennial tree or vine is typically asynchronous and rarely investigated. In commerce, this is problematic as it impairs sampling to meet commercial maturity and quality standards at harvest. For grapevines, understanding within-grapevine variability in berry maturity will benefit precision management and harvest planning. It is accepted that variation in maturity is approximately equally allocated at the within- and between-vine scale. However, the mechanistic and ecological factors that cause functional variance are poorly understood and rarely documented.This study aimed to identify structural and spatial within-vine attributes associated with berry composition at harvest related to available resources from the whole grapevine. Vegetative and reproductive biomass attributes within- and between-vines were analysed for cv. Cabernet-Sauvignon trained as a cordon, spur-pruned system using a Smart-Dyson trellis in a ‘New World’ industrial-scale vineyard. The vines were located in northern Margaret River, Western Australia. Variability in soluble solids, anthocyanins and phenolics were analysed for clusters and corresponding canopy characteristics.Berry size was the best predictor of variance in maturity among sugar, anthocyanins and phenolics composition within individual vines. Smaller stems or fruit had greater variation in maturity than larger stems or fruit. However, the relationship between whole plant biomass and fruit maturity interacted at different scales; the first report for grapevines. Including different vine-biomass scales helped explain the heteroscedasticity observed when the individual vine effect was excluded from the analysis. These findings suggest that high vigour grapevines could benefit from differential management, regardless of harvest index. Furthermore, these findings may help explain the diversity of response to treatment effects such as cluster or leaf thinning reported previously for perennial fruit.
Grapevine treatment with bagasse vermicompost changes the microbiome of Albariño must and wine and improves wine quality
Authors: Rosado Daniela , Ramos-Tapia Ignacio , Crandall Keith A. , Pérez-Losada Marcos , Domínguez Jorge
Published: August 2022

Winemaking is a well-known process comprising several steps to produce must and wine. Grape marc is a byproduct of wine production that can be vermicomposted and used as organic fertiliser. Grape marc vermicompost has a richer and more stable microbiome than grape marc alone and when added to the soil of vineyards it can improve grape production and wine quality. We compared Albariño must and wine microbiotas from grapevines treated with vermicompost derived from Albariño grape marc and controls (standard fertilisation). We hypothesised that observed microbial changes are connected to improved organoleptic properties observed in fertilised must and wine. Treated Albariño vines showed increased grape production and the final wine showed improved organoleptic properties. Metataxonomic analyses of the 16S rRNA and ITS gene regions showed that the Albariño must and wine microbiome varied in their taxonomic composition. Must bacteriotas showed no significant (p < 0.05) variation in alpha or beta-diversity, while wine bacteriotas and must and wine mycobiotas showed significant differences in richness and evenness, as well as in microbial structure (beta-diversity) between treated and control grapevines. Must and wine bacteriotas also showed significant (p < 0.05) changes in their predicted metabolic pathways. Our study suggests that changes in the abundance of specific bacterial and fungal taxa and the metabolic processes they carry out during Albariño winemaking can improve the productivity of the grapevine and the organoleptic properties of the wine.
Airborne Microplastic in the Atmospheric Deposition, How to Identify and Quantify the Threat? Novel Semi-quantitative Approach based on Kraków Case Study
Authors: Jarosz Kinga , Janus Rafał , Wądrzyk Mariusz , Wilczyńska-Michalik Wanda , Natkański Piotr , Michalik Marek
Published: August 2022

Airborne microplastic (MP) is an emerging pollutant, still under-characterised and insufficiently understood. Detailed description of MP air pollution is crucial as it has been identified in human lungs and remote locations, highlighting atmosphere as medium of MP dispersion and transportation. The lack of standardization of methods for measuring and further monitoring of the MP pollution is an obstacle towards the assessment of health risks. Since the first recognition of MP presence in the atmosphere of Krakow in 2019, this research was conducted to further characterise and develop the methods for qualitative and quantitative analysis of airborne MP (ATR-FTIR, Pyr-GC-MS, SEM-EDS) and pre-treatment of samples.The data was gathered in seven cycles, from June 2019 to February 2020. Methods used in the study allowed the identification and analysis of the changing ratio of the different types of synthetic polymers identified in the atmospheric fallout (LDPE, Nyl-66, PE, PET, PP, PUR). Observations of interactions between MP particles and environment were made with analyses of surface changes due to the degradation. Mineral phases attached to the MPs’ surfaces, with some of the inorganic contaminants transported on these surfaces, determined to also be of anthropogenic origin.Methodology proposed in this study, allows further characterisation of MP from multiple locations to provide highly comparable data, leading to the identification of the sources of this phenomenon, as well as seasonal changes.
Numerical Simulation and Characterization of the Hydrogeomechanical Alterations at the Zafarraya Fault Due to the 1884 Andalusia (Spain) Earthquake
Authors: Mudarra-Hernández Manuel , Mosquera-Feijoo Juan Carlos , Sanz-Pérez Eugenio
Published: August 2022

The 1884 Andalusia Earthquake, with an estimated Magnitude between 6.2 and 6.7, is one of the most destructive events that shook the Iberian Peninsula, causing around 1200 casualties. Ac-cording to both paleoseismology studies and intensity maps, the earthquake source relates to the normal Ventas de Zafarraya Fault (Granada, Spain). Diverse hydrological effects were registered and later studied: landslides, rockfalls, soil liquefaction, all-around surge and loss of springs, alter-ations in the phreatic level, discharge in springs and brooks, and well levels, along with changes in water properties. Further insight into these phenomena found an interplay between hy-dro-geomechanical processes and crust surface deformations, conditions, and properties. This study focuses on simulating the features involved by the major 1884 event and aims at elucidating the mechanisms concerning the mentioned effects. It encompasses conceptual geological and kinematic models, and a 2D finite element simulation to account for the processes undergone by the Zafarraya Fault. The study focuses on the variability of hydro-geomechanical features and the time evolution of the ground pore-pressure distribution in both the preseismic and coseismic stag-es, matching some of the shreds of evidence found by field studies. This methodology can be ap-plied to other events registered in the National Catalogues of Earthquakes to reach a deeper in-sight, further knowledge, and better understanding of past earthquakes.
Complexity Analyses of Surface Electromyography to Assess the Effects of Warm-up and Stretching during Maximal and Sub-Maximal Hamstring Contractions
Authors: Babault Nicolas , Hitier Marion , Cometti Carole
Published: August 2022

This study aimed to apply different complexity-based methods to surface electromyography (EMG) in order to detect neuromuscular changes after realistic warm-up and stretching procedures. Sixteen volunteers conducted two experimental sessions. They were tested before, after a standardized warm-up, and after a stretching exercise (static or neuromuscular nerve gliding technique). Tests included measurements of the knee flexion torque and EMG of biceps femoris (BF) and semitendinosus (ST) muscles. EMG was analyzed using the root mean square (RMS), sample entropy (SampEn), percentage of recurrence and determinism following a recurrence quantification analysis (%Rec and %Det) and a scaling parameter from a detrended fluctuation analysis. Torque was significantly greater after warm-up as compared to baseline and after stretching. RMS was not affected by the experimental procedure. In contrast, SampEn was significantly greater after warm-up and stretching as compared to baseline values. %Rec was not modified but %Det for BF muscle was significantly greater after stretching as compared to baseline. The a scaling parameter was significantly lower after warm-up as compared to baseline for ST muscle. From the present results, complexity-based methods applied to the EMG give additional information than linear-based methods. They appeared sensitive to detect EMG complexity increases following warm-up.
Burnout and Mental Interventions among Youth Athletes：A Meta-Analysis of the Studies
Authors: Wilczyńska Dominika , Wen Qi , Jaenes José Carlos , Alarcón David , Arenilla María José , Lipowski Mariusz
Published: August 2022

(1) Background: The subject of athlete burnout is often discussed among sports psychologists. Interventions to reduce this phenomenon are still under investigation with follow-up. Thus, the purpose of the current meta-analysis was to examine psychological interventions that have already been carried out to decrease or eliminate burnout syndrome in young athletes. (2) Methods: Scientific electronic databases were searched and five published studies published between January 2002 and June 2022, which met the criteria, were selected. This systematic review and meta-analyses followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cochrane Collaboration's tool for assessing the risk of bias was used to assess the studies' quality. The metafor a package of the R statistical program was used to perform the analysis. (3) Results: Cognitive-behavioral therapy as well as mindfulness-based interventions effectively reduced most dimensions of burnout. Moreover, online interventions were significantly more beneficial in this reduction (4) Conclusions: There should be more high-quality studies on the effectiveness of psychological interventions in reducing burnout. Mainly because it leads to tremendous physical and psychological problems for athletes and their coaches and therefore requires particular interventions and prevention strategies.
Using of N-Dimensional Euclidean Distance to Determine Location with Lack of Hospital with Health Social Security Agency Service
Authors: Alif Satrio Muhammad , Lestari Mardiana Tri
Published: August 2022

Health Social Security Agency or Badan Penyelenggara Jaminan Sosial Kesehatan (BPJSK) is a health to make people pays inexpensive price to get medical treatment. One of the shortcomings of BPJSK is regency of BPJSK card owner must be identical with the regency of target hospital. Lampung Province has varying location and uneven distribution of hospitals especially in regencies. This study aims to determine location with lack of hospital with BPJSK by using of n-dimensional Euclidean distance. The three-dimensional coordinate of 2098 sample points (SP) and 77 hospitals are the quantitative parameter used to calculate the distance. Every hospital and SP are assigned an identity number depending on the regency of each hospital and SP. Each SP pairs with its closest hospital. The SP with different identity is grouped. 32.1% of area of Lampung Province is the location with lack of hospital with BPJSK. The most prioritized regencies is Pringsewu Regency based on the distance and the population. Further research about spatial analyzing the exact location to build hospital with BPJSK service should be conducted.
Implementation of Health Protocols by the Community during Ramadhan and Eid al-Fitr 2021
Authors: Musthofa Muhammad Safrudin , Rizki Muhammad Ivan , Hasan Nugroho , Mustafa Alfian K , Widodo Ananda R , Rusdiyana Eksa
Published: August 2022

Covid-19 pandemic has changed human habit and mindset throughout world. Covid-19 has infected millions people globally in short period of time. This research aims to analyze the implementation of health protocols during Ramadhan and Eid al-Fitr celebration in the people of Karanganyar Regency, Central Java. This research used a descriptive qualitative approach, and data was collected using google form to be analyzed later with percentage tabulation. The result shows that during Ramadhan, the implementation of health protocols involving wearing mask, washing hand with soap, limiting the activity of breaking the fast together reached 80.3% (self-protection), 70.8% (protection of others), but the enforcement of health protocols during Eid al-Fitr celebration reached 44.2% only. It is related to the society value still upholding the cultures of silaturahim(making friendship), shaking hand, and visiting each other.  
Parental Assistance for Children's Learning Process in the Era of the Covid-19 Pandemic
Authors: Ronggowulan Lintang , Yusup Yasin , Subarno Anton , Lelono Sarjoko , Sutarno Sutarno , Wibowo Yunus Ari , Saputro Hikari Dwi , Kartika Fitria Dewi
Published: August 2022

The impact of the Covid-19 pandemic on the education sector is very significant. The face-to-face learning process turned into distance learning. This study aimed to obtain information about parental understanding and forms of parental support for children in the learning process during the Covid-19 Pandemic Era in Ngoro Tengah Hamlet, Triyagan Village, Mojolaban District, Sukoharjo Regency. The method used is descriptive qualitative. In this research, we distributed questionnaires to parents of school-age children. And then, we provide counseling and distribute the questionnaires again. The results obtained are that it can be seen that the level of understanding of the community in the Ngoro Tengah Hamlet, Triyagan Village, Mojolaban District, and Sukoharjo Regency regarding the children's learning process in the Covid-19 pandemic era is relatively high, but it turns out that in the process of implementing online learning the respondents in this study stated that the difficulties in implementing online learning and feel that online learning makes respondents difficult and not optimal and the role of parents in the form of support for children in the learning process shows a good response with 95.77% supporting online learning.
HUBUNGAN POLA ASUH AUTHORITATIVE DENGAN KOMPETENSI SOSIAL PADA ANAK USIA 5 – 6 TAHUN
Authors: Nuritasari Fadhila , Rasmani Upik Elok Endang , .Jumiatmoko Jumiatmoko
Published: August 2022

Kompetensi sosial perlu dimiliki anak sejak usia dini untuk berinteraksi secara baik terhadap lingkunganya dan supaya anak tidak berperilaku negatif serta menjadi antisosial. Salah satu faktor yang dapat mempengaruhi kompetensi sosial adalah pola asuh. Pola asuh yang banyak diterapkan oleh orang tua adalah pola asuh authoritative karena selalu melibatkan anak dalam kegiatan keluarga dan memberikan kebebasan anak tetapi tetap memberikan batasan pada anak. Tujuan penelitian ini adalah untuk menguji hubungan antara pola asuh authoritative dengan kompetensi sosial pada anak usia 5-6 tahun di TK Se-Kelurahan Gadingan, Mojolaban, Sukoharjo. Pendekatan penelitian ini yaitu pendekatan kuantitatif dengan jenis korelasi. Penelitian ini dilakukan pada Januari 2020 menggunakan sampel 56 anak. Pengambilan data penelitian ini menggunakan kuisioner dan diisi oleh orang tua. Hasil hipotesis dilaksanakan dengan uji Spearman Rho. Hasil menunjukkan nilai signifikansi sebesar 0,042 < 0.05 yang bermakna ada hubungan antara pola asuh authoritative dengan kompetensi sosial pada anak usia 5-6 tahun. Koefisien korelasi yang didapatkan sebesar 0,273. Kesimpulan dari penelitian ini adalah semakin baik pola asuh authoritative maka semakin baik kompetensi sosial anak pada anak usia 5 – 6 tahun di TK Se-Kelurahan Gadingan, Mojolaban, Sukoharjo.
Hubungan Motivasi Kerja terhadap Kinerja Guru PAUD pada Masa Pandemi di Kecamatan Laweyan
Authors: Yumna Mutia Shanaz , Wahyuningsih Siti , Rahmawati Anayanti
Published: August 2022

Penelitian ini di lakukan dengan tujuan untuk mengetahui hubungan motivasi kerja terhadap kinerja guru, yang menjadi latar belakang penelitian ini adalah adanyaa dugaan motivasi kerja guru yang tidak stabil akibat tekanan pekerjaan yang meningkat pada masa pandemi, sehingga dikhawatirkan terjadi adanya hubungan terhadap kinerja guru.Jenis penelitian ini merupakan penelitian dengan metode kuantitatif yang menggunakan jenis penelitian korelasi. Peneliti melakukan pembatasan masalah terhadap motivasi kerja guru dan kinerja pada guru PAUD dengan kriteria pada guru yang menyandang status bersertifikat dengan jenjang pendidikan S1 di TK Kecamatan Laweyan. Sampel yang diambil dalam penelitian ini menggunakan teknik Simple Random Sampling sebanyak 42 orang guru. Teknik analisis Pearson Product Moment digunakan untuk mengetahui tingkat hubungan antara kedua variabel, yaitu variabel motivasi kerja sebagai variable independen (X) dan variabel kinerja guru PAUD sebagai variable dependen (Y). Data yang terkumpul selanjutnya diuji melalui bantuan SPSS 25.Hasil analisis data diketahui nilai Sig. (2-tailed) 0,000 < dari 0,05 maka dikatakan memiliki korelasi yang artinya terdapat hubungan antara X dengan Y. Koefisien korelasi menunjukkan nilai sebesar 0,641 yang berada pada tabel kategori tingkat hubungan yang kuat. Angka koefisien korelasi di atas bernilai positif, yaitu sebesar 0,641 maka arah hubungan variabelnya dikatakan positif.
Tota familia Aristotelis: On Some Sources of Bacon’s Contribution to Medieval Political Discourse
Authors: Lambertini Roberto
Published: August 2022

Writing his Moralis philosophia, Roger Bacon discussed issues relevant to medieval political discourse. He felt the need to appeal to the authority of Aristotle, but having no access to Aristotle’s Politica, he tried to reconstruct its main tenets through the writings of other thinkers, such as Avicenna and Alfarabi. The result of this attempt is a sketch of a political theory that goes mainly under the name of Aristotle but has little to do with the actual contents of the Politica. In the following years, Bacon remained faithful to his first reconstruction. The author suggests that, with all probability, Bacon, never read the actual text of the Politica. the result is that Bacon’s contribution in this field was not influenced by Aristotle’s political masterpiece, but by other texts, in particular by Avicenna’s Philosophia prima. Such an assessment should not imply a negative judgement on Bacon. Rather, we should consider him among those authors who contributed to the rich diversity of medieval political thought independent of Aristotle’s Politica.
Effect of Gel Formulation of Methanolic Extract of Leucaena leucocephala Leaves on Propionibacterium acnes and Staphylococcus epidermidis
Authors: Sidharta Boy Rahardjo , Malaha Astri , Mursyanti Exsyupransia
Published: August 2022

White lead tree (Leucaena leucocephala) leaf extract includes antibacterial phytochemical compounds such as lupeol and flavonoids. The study aimed to determine the antibacterial activity of white lead tree methanolic extract and gel formulation against acne-causing bacteria Propionibacterium acnes and Staphylococcus epidermidis, also the physical quality of the preparation. The treatments included a methanolic extract of the White lead tree and extract gel formulations. The study used a completely randomized design (CRD) with five replications. ANOVA analyzed data at a 95% confidence level (p < 0.05) by SPSS software. Gel formulations were used in five concentrations (3.12, 6.25, 12.50, 25.00 and 50.00 %). The antibacterial activity test utilized was the agar diffusion method. The results showed the white lead tree leaf extract contains flavonoids with TFC as much as 12.33 + 0.02 mgQE.g-1. The antibacterial activity test of white lead tree leaf extract at all concentrations showed the most effective antibacterial activity against S. epidermidis with a zone of inhibition of 2.17 cm2, with no inhibitory zone against P. acnes. The gel preparation extract at all concentrations had no inhibitory activity against P. acnes, but the gel formulations inhibit S. epidermidis effectively at 50.00 % concentrations with a zone of inhibitions 0.82+0.30 cm2. The gel quality parameters looked homogeneity for 28 days; ph and stickiness were matched to the National Standardization Agency of Indonesia (NSI); however, the dispersibility and viscosity were not matched to NSI. In conclusion, plant leaf methanolic extract demonstrated antibacterial activity against the acne-causing bacterium S. epidermidis. Further study is needed on the potential of white lead tree leaves as a natural anti-acne.
Human basic Fibroblastic Growth Factor production by codon optimization in rice cell suspension culture
Authors: Bastami Meysam , Hosseini Ramin
Published: August 2022

Human basic fibroblastic growth factor (hbFGF), possesses several highly important biological functions, such as cell proliferation, protein synthesis and metabolism. This study is the first investigation to transfer a hbFGF gene cassette into rice cells. To improve the human bFGF expression in rice an optimized coding sequence was developed. Following synthesis, the expression cassette was constructed by fusing the PCR- amplified RAm3D promoter and terminator sequences to the codon-optimized hbFGF sequence. Then, the cassette was transferred into the pCAMBIA1304 shuttle vector. This vector also contained the RAmy3D signal peptide for the secretion of the recombinant protein into the culture medium. Rice (Oryza sativa cv. Kanto 51) seeds were cultured on the 2N6PG medium composing of the N6 basal medium supplemented with 2 mg/L 2,4-D for callus induction. Callus transformation was performed by employing Agrobacterium tumefaciens strain LBA 4404. The verification of bFGF gene integration into the chromosomes of putative transgenic calli was carried out by genomic DNA PCR. A transformed callus line expressing the highest level of bFGF (38.1 mg/kg FW) was recognized by ELISA and selected to establish cell suspension culture. The expression and secretion of the recombinant bFGF into the culture medium in the developed transgenic rice cell culture was evident on day 3 after incubation of cells in the sucrose-free medium. The recombinant bFGF with a molecular weight of ~ 17 kDa was detected by the Western blot and SDS-PAGE analyses in the culture medium under reducing conditions. The purification of bFGF was performed using HiTrap Heparin HP column. The activity assay indicated that the rice derived bFGF stimulated the proliferation of NIH/3T3 cells similar to the commercial bFGF.
Effectiveness and Economic Outcomes in Patients Undergoing Laparoscopic Prostate Resection with a New Surgical Shear with Integrated Energy System: a retrospective study based on a tertiary hospital database in China
Authors: Gao Yi , Zhu Yu , Sun Fukang , Shao Yuan , Huang Tao , He Wei , Xie Xin , Chen Lu , Winberg Debra R. , Xu Danfeng
Published: August 2022

Background
Each year over 1.4 million men are diagnosed with prostate cancer. Surgical prostate resection offers patients with early-stage prostate cancer a high likelihood of remission and has low reoperation rates. A new surgical shear with integrated energy system (Harmonic ACE + 7) is an integrated ultrasonic and electrosurgical energy system that can aid surgeons in laparoscopic prostate resections. This study aimed to demonstrate the ACE + 7’s value by determining its effectiveness and economic outcomes compared to conventional ultrasonic shear (CUS) in a real-world setting.
Methods
This was a multi-center clinical study of adults with prostate cancer undergoing a laparoscopic prostate resection procedure with the ACE + 7 shear or CUS between August 2019 and April 2021 at Shanghai Ruijin Hospital and two affiliated centers. Demographic and diagnosis information, intraoperative and postoperative clinical outcomes, and total and categorical costs were collected. 1:1 Propensity Score Matching was performed to form the study population for each clinical group. Data were compared between the two groups using t-tests and chi-squared tests.
Results
The ACE + 7 was associated with a lower number of hemostatic clips used per surgery (12.8 in the ACE + 7 group vs 19.8 in the CUS group, P < 0.001), a moderate but not significant difference in average postoperative drainage duration (6.6 ± 2.2 d vs. 7.9 ± 4.1 d, P = 0.082), a reduction on total drainage volume (275.5 ± 374.3 ml vs. 492.9 ± 1495.0 ml, P = 0.321) and a lower average rate of postoperative hemostatic drug usage (16% vs. 52%, P < 0.001). There was no significant difference in total costs between the ACE + 7 and CUS groups.
Conclusion
This study provides real-world data demonstrating that the ACE + 7 shear with integrated energy system improves clinical outcomes compared to CUS and can offer cost savings for hospitals and health systems. Using the ACE + 7's during LPRs allows physicians to help their patients achieve better outcomes and not spend additional money.
Trial Registration:
This study is a retrospective, observational study based on data from existing Electronical Hospital Information System and no human intervention was involved.
Atomic-scale identification of the active sites of nanocatalysts
Authors: Yang Yao , Zhou Jihan , Zhao Zipeng , Sun Geng , Moniri Saman , Ophus Colin , Yang Yongsoo , Wei Ziyang , Yuan Yakun , Zhu Cheng , Liu Yang , Sun Qiang , Jia Qingying , Heinz Hendrik , Ciston Jim , Ercius Peter , Sautet Philippe , Huang Yu , Miao Jianwei (John)
Published: August 2022

Heterogeneous catalysts play a key role in the chemical and energy industries1. To date, most industrial-scale heterogeneous catalytic reactions have relied on nanocatalysts2,3. However, despite significant progress from theoretical, experimental and computational studies4-18, identifying the active sites of alloy nanocatalysts remains a major challenge. This limitation is mainly due to an incomplete understanding of the three-dimensional (3D) atomic and chemical arrangement of different constituents and structural reconstructions driven by catalytic reactions19-22. Here, we use atomic electron tomography23 to determine the 3D local atomic structure, surface morphology and chemical composition of 11 Pt alloy nanocatalysts for the electrochemical oxygen reduction reaction (ORR). We reveal the facet, surface concaveness, structural and chemical order/disorder, coordination number, and bond length with unprecedented 3D atomic detail. The experimental 3D atomic coordinates are used by first-principles trained machine learning to identify the active sites of the nanocatalysts, which are corroborated by electrochemical measurements. A striking feature is the difference of the ORR activity of the surface Pt sites on the nanocatalysts by several orders of magnitude. Furthermore, by analyzing the structure-activity relationship, we formulate an equation named the local environment descriptor to balance the strain and ligand effects and gain quantitative insights into the ORR active sites of the Pt alloy nanocatalysts. The ability to determine the 3D atomic structure and chemical composition of realistic nanoparticles coupled with machine learning could transform our fundamental understanding of the catalytic active sites and provide a guidance for the rational design of optimal nanocatalysts.
Upcycling yield trial data using a weather-driven crop growth model
Authors: Shimono Hiroyuki , Abe Akira , Kim Chyon , Sato Chiashi , Iwata Hiroyoshi
Published: August 2022

Screening new cultivars through yield trials in multiple environments has improved crop yields, but the accumulated data from these trials has not been effectively reused. We propose a simple method that quantifies cultivar-specific characteristics of productivity using two regression coefficients for yield-ability (β) and yield-plasticity (α). The recorded yields of each cultivar were expressed using a unique linear regression in response to the theoretical potential yield calculated by a weather-driven crop growth model called the “YpCGM method.” We applied this analysis to 72,510 independent datasets from yield trials of rice (Oryza sativa L.) that used 237 core cultivars measured in breeding programs at 110 locations in Japan over 38 years. The coefficients of β and α differed among the 237 cultivars, with values ranging from 2.5 to 7.3 t/ha and from –0.23 to +0.95, respectively. Genomic prediction validated the values of these two coefficients by a 10-fold cross-validation based on pedigree information and the rice genome’s 91,800 single-nucleotide polymorphisms. The YpCGM method can upcycle accumulated yield data for use in genetic gain analysis and genome-wide association studies to guide future breeding programs in developing new cultivars suitable for the world’s changing climate.
Nischarin expression may have differing roles in male and female melanoma patients
Authors: Ostojić Marija , Jevrić Marko , Mitrović-Ajtić Olivera , Tanić Miljana , Čavić Milena , Srdić-Ra Tatjana , Grahovac Jelena
Published: August 2022

Due to the development of resistance to previously effective therapies, there is a constant need for novel treatment modalities for metastatic melanoma. Nischarin (NISCH) is a druggable scaffolding protein reported as a tumor suppressor and a positive prognostic marker in breast and ovarian cancers through regulation of cancer cell survival, motility and invasion. The aim of this study was to examine the expression and potential role of nischarin in melanoma. We found that nischarin expression was decreased in melanoma tissues compared to the uninvolved skin, and this was attributed to the presence of microdeletions and hyper-methylation of the NISCH promoter in the tumor tissue. In addition to the previously reported cytoplasmic and membranous localization, we observed nischarin in the nuclei in melanoma patients’ tissues. NISCH expression in primary melanoma had favorable prognostic value for female patients, but, unexpectedly, high NISCH expression predicted worse prognosis for males. Gene set enrichment analysis suggested significant sex-related disparities in predicted association of NISCH with several signaling pathways, as well as with different tumor immune infiltrate composition in male and female patients. Taken together, our results imply that nischarin may have a role in melanoma progression, but that fine-tuning of the pathways it regulates is sex-dependent.
Persisting cognitive impairment predicts functional dependence at 1 year after stroke and transient ischemic attack: a longitudinal, cohort study
Authors: Liao Xiaoling , Zuo Lijun , Pan Yuesong , Xiang Xianglong , Meng Xia , Li Hao , Zhao Xingquan , Wang Yilong , Shi Jiong , Wang Yongjun
Published: August 2022

Objective: Minor stroke or transient ischemic attack (TIA) usually have mild and nondisabling symptoms, and these physical deficits may recover to some extent, however, part of them still suffer from cognitive impairment and poor outcomes. We conducted a study to determine the relationship between cognition and poor outcomes. Methods—The data of this study come from the impairment of cognition and Sleep (ICONS) after acute ischemic stroke or transient ischemic attack in Chinese patients study. A total of 1675 minor stroke patients and TIA patients were finally recruited. Patients’ cognition were evaluated by Montreal Cognitive Assessment (MoCA) scale at 2-week (2w), 3 months (3m) and 1 year(1y). Cognitive impairment (CI) was defined as MoCA score≤22. According to MoCA score, patients were divided into 4 groups: no PSCI group: with MoCA-2w＞22 and MoCA-3m＞22; improved PSCI group: with MoCA-2w≤2 and MoCA-3m＞22;delayed PSCI group: MoCA-2w＞22 and MoCA-3m≤22; persisting PSCI group: with MoCA-2w≤22 and MoCA-3m≤22. Results—There were 818 patients (48.84%) have PSCI at baseline. And there were 123 patients (15%) have stroke disability defined by mRS ≥2 at 3 months in CI group. The persisting PSCI group was a significant predictor of functional dependence at 3 months and 1 year after stroke and when adjusted for covariates such as gender, age, history of stroke, depression and intracranial atherosclerotic stenosis, stroke subtype and acute infarction type. Conclusion: Persisting PSCI increased the risk of poor functional outcome after 3 months and 1 year follow-up. These high-risk individuals should be identified for targeted rehabilitation and counseling to improve longer-term post-stroke outcome.