bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Gold‐Catalyzed Hydroarylation of Alkenes with Dialkylanilines.
Authors: Hu Xingbang , Martin David , Melaimi Mohand , Bertrand Guy
Published: March 2015

Anti‐Bredt di(amino)carbene supported gold(I) chloride complexes in combination with KB(C6F5)4 as chloride scavenger promote the hydroarylation of styrenes, norbornene, and enones with dialkylanilines in fair to high yields with good para‐selectivity.
ChemInform Abstract: Chelating Ruthenium Phenolate Complexes: Synthesis, General Catalytic Activity, and Applications in Olefin Metathesis Polymerization.
Authors: Kozlowska Anna , Dranka Maciej , Zachara Janusz , Pump Eva , Slugovc Christian , Skowerski Krzysztof , Grela Karol
Published: March 2015

Ru‐Complexes (I) and (II) are prepared and investigated in ring‐closing, enyne, and cross‐metathesis reactions.
ChemInform Abstract: Homologation of Isocyanates with Lithium Carbenoids: A Straightforward Access to α‐Halomethyl‐ and α,α‐Dihalomethylamides.
Authors: Pace Vittorio , Castoldi Laura , Mamuye Ashenafi , Holzer Wolfgang
Published: March 2015

In the case of isocyanates with optically active residues, full preservation of chiral information is observed.
ChemInform Abstract: New Approach to α‐Pentafluorosulfanyl‐Substituted Carboxylic Acid Derivatives via Ireland‐Claisen Rearrangements.
Authors: Dreier Anna‐Lena , Matsnev Andrej V. , Thrasher Joseph S. , Haufe Guenter
Published: March 2015

Allylic esters (III) undergo Ireland—Claisen rearrangements to form γ,δ‐unsaturated α‐pentafluorosulfanyl carboxylic acids, which are isolated as their methyl esters (V).
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Enantioselective Synthesis of Functionalized Cyclopentenes via α,β‐Unsaturated Acyl Azoliums.
Authors: Mondal Santigopal , Yetra Santhivardhana Reddy , Patra Atanu , Kunte Sunita S. , Gonnade Rajesh G. , Biju Akkattu T.
Published: March 2015

Highly enantioselective NHC‐organocatalyzed synthesis of functionalized cyclopentenes proceeding via α,β‐unsaturated acyl azolium intermediates is reported.
ChemInform Abstract: A Versatile and Efficient Palladium‐meta‐Terarylphosphine Catalyst for the Copper‐Free Sonogashira Coupling of (Hetero‐)Aryl Chlorides and Alkynes.
Authors: Yang Yong , Chew Xinying , Johannes Charles W. , Robins Edward G. , Jong Howard , Lim Yee Hwee
Published: March 2015

The novel title ligand TAP, when combined in situ with a Pd‐source [cf.
ChemInform Abstract: Rhodium‐Catalyzed Oxidative Perfluoroalkenylation by Carbonyl Group Directed C—H Bond Activation.
Authors: Kathiravan Subban , Nicholls Ian A.
Published: March 2015

A broad spectrum of substrates bearing a cyclic or acyclic keto function can be used in the title reaction with esters (II), (VII), and (XVIII).
ChemInform Abstract: A Synthetic and Mechanistic Investigation into the Cobalt(I) Catalyzed Amination of Aryl Halides.
Authors: Brennan Marshall R. , Kim Dongyoung , Fout Alison R.
Published: March 2015

The first Co(I)‐catalyzed amination of unactivated aryl iodides with (TMS)2NLi for the formation of anilines, including those not accessible by other cross‐coupling methods, is described.
ChemInform Abstract: BrettPhos Ligand Supported Palladium‐Catalyzed C—O Bond Formation Through an Electronic Pathway of Reductive Elimination: Fluoroalkoxylation of Activated Aryl Halides.
Authors: Rangarajan T. M. , Singh Rajendra , Brahma Raju , Devi Kavita , Singh Rishi Pal , Singh R. P. , Prasad Ashok K.
Published: March 2015

The optimized conditions allow the fluoroalkoxylation of aryl bromides and chlorides bearing electron withdrawing functional groups.
ChemInform Abstract: Pd‐NHC‐Catalyzed Synthesis of Diaryl Ketones.
Authors: Gao Feng , Feng Huangdi , Sun Zhihua
Published: March 2015

A simple protocol allows the coupling of N‐acylphthalimides and aryl boronic acids to give diaryl ketones.
ChemInform Abstract: Enantioselective C—H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene.
Authors: Yu Peng , Lin Jin‐Shun , Li Lei , Zheng Sheng‐Cai , Xiong Ya‐Ping , Zhao Li‐Jiao , Tan Bin , Liu Xin‐Yuan
Published: March 2015

The first examples of an enantioselective redox‐neutral tandem process providing simultaneous formation of C—CF3 and C—O bonds by functionalization of a C—H bond adjacent to an amide, triggered by CF3‐radical addition to an alkene.
ChemInform Abstract: A Green Protocol for the N‐Formylation of Amines Using Molybdate Sulfuric Acid as a Reusable Solid Catalyst.
Authors: Karami Bahador , Farahi Mahnaz , Pam Fariba
Published: March 2015

The method succeeds using aliphatic primary and secondary as well as aromatic primary amines except sterically hindered ones such as diphenylamine or tert‐butyl amine.
ChemInform Abstract: Copper‐Catalyzed Acyloxylation of the C(sp3)—H Bond Adjacent to an Oxygen by a Cross‐Dehydrogenative Coupling Approach.
Authors: Raju Kammari Bal , Kumar Bejjanki Naveen , Nagaiah Kommu
Published: March 2015

The acyloxylation of ethers succeeds with variously substituted benzylic alcohols, but fails using aliphatic alcohols such as butyl or allyl alcohol.
ChemInform Abstract: A Mild and Fast Photocatalytic Trifluoromethylation of Thiols in Batch and Continuous‐Flow.
Authors: Straathof Natan J. W. , Tegelbeckers Bart J. P. , Hessel Volker , Wang Xiao , Noel Timothy
Published: March 2015

Some of the presented reactions are also performed using continuous‐flow instead of batch techniques in significantly reduced reaction times, but with varying yields.
ChemInform Abstract: Palladium‐Catalyzed Direct Thiolation of Ethers with Sodium Sulfinates.
Authors: Guo Shengrong , He Weimin , Xiang Jiannan , Yuan Yanqin
Published: March 2015

A new, simple, and mild method for the synthesis of aryl alkyl sulfides from ethers and sodium sulfinate is developed.
ChemInform Abstract: Lossen Rearrangements under Heck Reaction Conditions.
Authors: Abdel Hafez El‐Shimaa M. N. , Aly Omar M. , Abuo‐Rahma Gamal El‐Din A. A. , King S. Bruce
Published: March 2015

The Lossen rearrangement of aromatic hydroxamic acids under Heck conditions affords the corresponding aryl amines while aliphatic and hetaryl hydroxamic acids yield symmetric ureas.
ChemInform Abstract: Triphyrin Catalyzed Direct C—H Arylation of Benzene with Aryl Halides.
Authors: Xue Zhao‐Li , Qian Ying Ying , Chan Kin Shing
Published: March 2015

Phenyl iodide and aryl iodides equipped with electron‐donating groups react smoothly to afford biaryls.
ChemInform Abstract: Suzuki—Miyaura Coupling of Aryl Chlorides with Arylboronic Acids Using the Morpholine—NiCl2 Catalyst System.
Authors: Abe Taichi , Mino Takashi , Watanabe Kohei , Sakamoto Masami
Published: March 2015

The coupling of aryl chlorides succeeds with aryl and hetaryl boronic acids and even alkenyl boronic acids, but fails for alkyl boronic acids.
ChemInform Abstract: An Improvement of the Palladium‐Catalyzed [4 + 2] Cycloaddition of o‐(Silylmethyl)benzyl Carbonates with Alkenes.
Authors: Jin Yushu , Ishizuka Kentaro , Kuwano Ryoichi
Published: March 2015

Tris(4‐methoxy‐3,5‐dimethylphenyl)phosphane is evaluated as the ligand in hitherto unsuccesful Pd‐catalyzed transformations to substituted 1,2,3,4‐tetrahydronaphthalenes.
ChemInform Abstract: Gold(III)‐Catalyzed Enynamine—Cyclopentadiene Cycloisomerization with ChiralityTransfer: An Experimental and Theoretical Study Indicating Involvement of Dual Au(III) Push—Pull Assisted cis—trans Isomerism.
Authors: Wirtanen Tom , Muuronen Mikko , Melchionna Michele , Patzschke Michael , Helaja Juho
Published: March 2015

A synthetic approach for asymmetric ring‐fused cyclopentadienes with a chiral carbon at the ring junction is established from chiral enynamines by achiral Au(III) catalysis.
ChemInform Abstract: An Organocatalytic Domino Michael‐Alkylation Reaction: Highly Enantioselective Construction of Spiro‐Cyclopentanoneoxindoles and Tetronic Acid Scaffolds.
Authors: Zhou Jing , Wang Qi‐Lin , Peng Lin , Tian Fang , Xu Xiao‐Ying , Wang Li‐Xin
Published: March 2015

The title reaction of methyleneindolinones with ketoester (II) results in the formation of various spiro‐cyclopentanoneoxindoles which are obtained in high yields, good diastereoselectivities and excellent enantioselectivities via α‐alkylation.
ChemInform Abstract: Titanium Salan Catalysts for the Asymmetric Epoxidation of Alkenes: Steric and Electronic Factors Governing the Activity and Enantioselectivity.
Authors: Talsi Evgenii P. , Samsonenko Denis G. , Bryliakov Konstantin P.
Published: March 2015

Screening experiments of titanium salan catalysts show, that electronic effects modulate the catalytic activity, whereas steric effects account for the enantioselectivity of the process.
ChemInform Abstract: Gold Catalyzed Synthesis of Fluorinated Tetrahydrofurans and Lactones.
Authors: Malhotra Deepika , Liu Leping , Wang Weibo , Durham Mallory , Hammond Gerald B. , Xu Bo
Published: March 2015

Gold‐catalyzed tandem cycloisomerization/fluorination of alkynylic alcohols (I) gives difluoro hydroxyl tetrahydrofurans of type (II).
ChemInform Abstract: Facile Synthesis of Pyrroles via Rh(II)‐Catalyzed Transannulation of 1‐Tosyl‐1,2,3‐triazoles with Silyl or Alkyl Enol Ethers.
Authors: Feng Juan , Wang Yuanhao , Li Qingong , Jiang Renwang , Tang Yefeng
Published: March 2015

The title reaction proceeds with high regioselectivity and provides a wide range of substituted pyrroles.
ChemInform Abstract: Synthesis of Enantiopure Furo[2,3‐b]pyrroles.
Authors: Nair Divya S. , Ibnusaud Ibrahim
Published: March 2015

This diastereo‐ and enantioselective synthesis of dihydroxyhexahydrofuro[2,3‐b]pyrrolones comprises the preparation of the key structural element of physovenine, madindoline and diazoamide A.
ChemInform Abstract: Direct Oxidative Coupling of N‐Acetyl Indoles and Phenols for the Synthesis of Benzofuroindolines Related to Phalarine.
Authors: Tomakinian Terry , Guillot Regis , Kouklovsky Cyrille , Vincent Guillaume
Published: March 2015

A novel direct oxidative [3 + 2] coupling of phenols and indoles to give a regioselective formation of benzofuro[3,2‐b]indolines (III) and (V), representing the phalarine core, is developed.
ChemInform Abstract: Synthesis of 7‐Azabicyclo[2.2.1]heptane‐1‐carboxylate via Silver/ThioClickFerrophos‐Catalyzed Asymmetric 1,3‐Dipolar Cycloaddition of Dihydropyrrole Ester with N‐Substituted Maleimide.
Authors: Tada Atsuo , Watanabe Sayo , Kimura Midori , Tokoro Yuichiro , Fukuzawa Shin‐ichi
Published: March 2015

The reaction yields and enantioselectivities achieved in the construction of these substituted pharmacologically relevant scaffolds are neither influenced by electronic nor steric substituent effects.
ChemInform Abstract: Photocatalytic Generation of N‐Centered Hydrazonyl Radicals: A Strategy for Hydroamination of β,γ‐Unsaturated Hydrazones.
Authors: Hu Xiao‐Qiang , Chen Jia‐Rong , Wei Qiang , Liu Feng‐Lei , Deng Qiao‐Hui , Beauchemin Andre M. , Xiao Wen‐Jing
Published: March 2015

Irradiation of solutions of β,γ‐unsaturated hydrazones (I), (III), and (V) with blue light LEDs gives the corresponding pyrazoles (II), (IV), and (VI).
ChemInform Abstract: Mechanism and Selectivity of N‐Triflylphosphoramide Catalyzed (3+ + 2) Cycloaddition Between Hydrazones and Alkenes.
Authors: Hong Xin , Kuecuek Hatice Baspinar , Maji Modhu Sudan , Yang Yun‐Fang , Rueping Magnus , Houk K. N.
Published: March 2015

Broensted acid‐catalyzed cycloadditions between hydrazones and alkenes give rise to a general approach to pyrazolidines.
ChemInform Abstract: Synthesis of a New Class of Bis Heterocycles.
Authors: Padmavathi Venkatapuram , Sreelatha Tumma , Reddy Putta Ramachandra , Divya Kuppireddygari
Published: March 2015

via 1,3‐dipolar cycloaddition of tosylmethyl isocyanide (III) or diazomethane (V) to oxazolyl‐, thiazolyl‐, and imidazolyl acrylamides
ChemInform Abstract: An Efficient Protocol for the Synthesis of Benzoheterocyclic Compounds via Solid‐State Melt Reaction (SSMR).
Authors: Bakthadoss Manickam , Selvakumar Raman , Srinivasan Jayakumar
Published: March 2015

The method serves for the facile synthesis of biologically active benzothiazoles, benzimidazoles, benzospirothiazoles, and quinoxalines, such as the anti‐tumor agents (IIId,e).
ChemInform Abstract: Polystyrene Resin‐Supported CuI‐Cryptand 22 Complex: A Highly Efficient and Reusable Catalyst for Three‐Component Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles under Aerobic Conditions in Water.
Authors: Movassagh Barahman , Rezaei Nasrin
Published: March 2015

The catalyst is used for the two‐component Huisgen [3 + 2]‐cycloaddition of alkynes and organic azides as well as the three‐component addition of alkynes, sodium azide and alkyl halides to form triazoles.
ChemInform Abstract: Organocatalysis in Aqueous Micellar Medium: A New Protocol for the Synthesis of [1,2,4]‐Triazolyl‐thiazolidinones.
Authors: Singh Mandavi , Saquib Mohammad , Singh Shyam Babu , Singh Swastika , Ankit Preyas , Fatma Shahin , Singh Jagdamba
Published: March 2015

The presented efficient method for the synthesis of biologically relevant hybrid triazolyl‐thiazolidinones is environmentally benign.
ChemInform Abstract: Transient Protection of Strained Alkynes from Click Reaction via Complexation with Copper.
Authors: Yoshida Suguru , Hatakeyama Yasutomo , Johmoto Kohei , Uekusa Hidehiro , Hosoya Takamitsu
Published: March 2015

The strained alkyne moiety of a cyclooctyne can be transiently masked through complexation with a copper(I) salt, thus enabling the selective copper‐catalyzed click conjugation with an azide at the terminal alkyne.
ChemInform Abstract: Synthesis and Biological Evaluation of New Oxadiazoline‐Substituted Naphthalenyl Acetates as Anticancer Agents.
Authors: Chaaban Ibrahim , El Khawass El Sayeda M. , Abd El Razik Heba A. , El Salamouni Nehad S. , Redondo‐Horcajo Mariano , Barasoain Isabel , Diaz J. Fernando , Yli‐Kauhaluoma Jari , Moreira Vania M.
Published: March 2015

All new oxadiazoline‐substituted naphthalenyl acetates (III), (V) are tested for their in vitro anticancer activity.
ChemInform Abstract: Broensted Acid/Lewis Acid Cooperatively Catalyzed Addition of Diazoesters to 2H‐Chromene Acetals.
Authors: Luan Yi , Qi Yue , Gao Hongyi , Ma Qianqian , Schaus Scott E.
Published: March 2015

The title reaction gives oxocarbenium precursors under mild conditions.
ChemInform Abstract: L‐Proline‐Catalyzed Unusual Product Formation from the Reaction of 4‐ Hydroxydithiocoumarin and Aldehydes Through a Pseudo‐Three‐Component Reaction.
Authors: Mahato Karuna , Ray Bagdi Prasanta , Khan Abu T.
Published: March 2015

The structure of the hitherto unknown compounds synthesized by an efficient protocol is proven by X‐ray analysis.
ChemInform Abstract: Oxidative Aromatization of Hantzsch 1,4‐Dihydropyridines by Cupric Bromide under Mild Heterogeneous Condition.
Authors: Saikh Forid , De Rimpa , Ghosh Somnath
Published: March 2015

In contrast to previously published procedures, this protocol does not only tolerate aryl, but also alkyl substituents.
ChemInform Abstract: Co(II), a Catalyst for Selective Conversion of Phenyl Rings to Carboxylic Acid Groups.
Authors: Sinha Shashi Bhushan , Campos Jesus , Brudvig Gary W. , Crabtree Robert H.
Published: March 2015

The Co(II)‐catalyzed oxidative conversion of the phenyl ring in aryl‐substituted pyridines using Oxone as oxidant is studied.
ChemInform Abstract: Metal‐Free Synthesis of Substituted Pyridines from Aldehydes and NH4OAc under Air.
Authors: Yan Rulong , Zhou Xiaoqiang , Li Ming , Li Xiaoni , Kang Xing , Liu Xingxing , Huo Xing , Huang Guosheng
Published: March 2015

Whereas substituted 2‐aryl propanals yield 3,5‐diarylpyridines, substituted 3‐aryl propanals react to 3,5‐diarylmethyl‐2‐(arylethyl)pyridines.
ChemInform Abstract: Synthesis of Substituted Quinoline via Copper‐Catalyzed One‐Pot Cascade Reactions of 2‐Bromobenzaldehydes with Aryl Methyl Ketones and Aqueous Ammonia.
Authors: Li Bin , Guo Chenhao , Fan Xuesen , Zhang Ju , Zhang Xinying
Published: March 2015

The reaction fails using aliphatic methyl ketones such as acetone, but succeeds with excellent efficiency for aromatic methyl ketones, thus providing an alternative approach to synthetically and medicinally relevant aryl‐substituted quinolines.
ChemInform Abstract: Synthesis of Substituted Quinolines via Allylic Amination and Intramolecular Heck‐Coupling.
Authors: Murru Siva , McGough Brandon , Srivastava Radhey S.
Published: March 2015

The method also succeeds for the preparation of a bis‐heterocyclic product (XIII) representing a derivative of medicinally relevant 1,5‐naphthyridines.
ChemInform Abstract: Keteniminium Ion‐Initiated Cascade Cationic Polycyclization.
Authors: Theunissen Cedric , Metayer Benoit , Henry Nicolas , Compain Guillaume , Marrot Jerome , Martin‐Mingot Agnes , Thibaudeau Sebastien , Evano Gwilherm
Published: March 2015

A highly efficient keteniminium‐initiated cationic polycyclization is developed.
ChemInform Abstract: Domino Synthesis of Fused Hexacyclic Imidazoquinolinoacridinones Catalyzed by CuI/l‐Proline.
Authors: Li Chao , Zhang Wen‐Ting , Wang Xiang‐Shan
Published: March 2015

The one‐pot procedure provides access to hexacyclic skeletons with two newly formed heterocycles and six newly formed bonds.
ChemInform Abstract: TBHP‐Promoted Sequential Carboxamidation and Aromatisation of Aryl Isonitriles with Formamides.
Authors: Feng Xiaomei , Zhu Hui , Wang Lei , Jiang Yan , Cheng Jiang , Yu Jin‐Tao
Published: March 2015

This efficient method for the synthesis of phenanthridine‐6‐carboxamides tolerates a range of functional groups and succeeds with formamides deriving from secondary cyclic and secondary acyclic aliphatic amino moieties.
ChemInform Abstract: SnO Nanoparticles as an Efficient Catalyst for the One‐Pot Synthesis of Chromeno[2,3‐b]pyridines and 2‐Amino‐3,5‐dicyano‐6‐sulfanyl Pyridines.
Authors: Safaei‐Ghomi Javad , Shahbazi‐Alavi Hossein , Heidari‐Baghbahadorani Elham
Published: March 2015

The catalyst is recycled and reused for five times without significant loss of activity.
ChemInform Abstract: Glyoxylic Acid in the Reaction of Isatoic Anhydride with Amines: A Rapid Synthesis of 3‐(Un)substituted Quinazolin‐4(3H)‐ones Leading to Rutaecarpine and Evodiamine.
Authors: Rao K. Raghavendra , Raghunadh Akula , Mekala Ramamohan , Meruva Suresh Babu , Pratap T. V. , Krishna T. , Kalita Dipak , Laxminarayana Eppakayala , Prasad Bagineni , Pal Manojit
Published: March 2015

Glyoxylic acid (II) serves as a reactant and the catalyst, thus playing a dual role in this novel and robust metal‐free reaction.
ChemInform Abstract: Polyethylene Glycol (PEG‐400): An Efficient Green Reaction Medium for the Synthesis of Benzo[4,5]imidazo[1,2‐a]‐pyrimido[4,5‐d]pyrimidin‐4(1H)‐ones under Catalyst‐Free Conditions.
Authors: Veeranarayana Reddy Mudumala , Kim Jong Su , Lim Kwon Taek , Jeong Yeon Tae
Published: March 2015

A simple protocol for the synthesis of the title species via three‐component reaction of amine (I), aromatic aldehydes (II), and 2‐cyanoacetamide (III).
ChemInform Abstract: New MCR Based on Intramolecular Heck Reaction under Aerobic Conditions: A Direct Access to Cytotoxic Fused N‐Heterocycles.
Authors: Adepu Raju , Prasad Bagineni , Ashfaq Mohd Ashraf , Ehtesham Nasreen Z. , Pal Manojit
Published: March 2015

Title compounds are prepared from isatoic anhydride (I), aromatic 2‐bromo‐substituted arylaldehydes, and allyl amine.
ChemInform Abstract: 1,1′‐Sulfinyldipyridinium Bis (Hydrogen Sulfate) Ionic Liquid: Synthesis and Application in the Temperature‐Influenced Synthesis of Novel Pyranopyrimidinediones and Pyranopyrimidinetriones.
Authors: Patil Jayavant D. , Korade Suyog N. , Pore Dattaprasad M.
Published: March 2015

At ambient temperature the reaction between 6‐amino uracil (I) and salicylaldehydes in ethanol provides pyranopyrimidinediones [cf.
ChemInform Abstract: Switching Between Reaction Pathways by an Alcohol Cosolvent Effect: SmI2—Ethylene Glycol vs SmI2—H2O Mediated Synthesis of Uracils.
Authors: Szostak Michal , Spain Malcolm , Sautier Brice , Procter David J.
Published: March 2015

The SmI2‐mediated reduction of barbituric acids using ethylene glycol as coordinating co‐solvent is followed by a 1,2‐migration process to give 6‐substituted uracils (II) and (IV).
ChemInform Abstract: One‐Pot Synthesis of 1H‐Pyrazolo[1,2‐b]phthalazine‐5,10‐dione Derivatives under Solvent‐Free Conditions.
Authors: Ghorbani‐Vaghei Ramin , Noori Samira , Toghraei‐Semiromi Zahra , Salimi Zahra
Published: March 2015

The catalyst is recovered and reused without decreasing the yield of the products.
ChemInform Abstract: 2,1‐Benzothiazine 2,2‐Dioxides. Part 5. Hydrolysis of Alkyl 1‐R‐4‐Hydroxy‐2,2‐dioxo‐1H‐2λ 6,1‐benzothiazine‐3‐carboxylates.
Authors: Ukrainets I. V. , Petrushova L. A. , Dzyubenko S. P. , Yangyang Liu
Published: March 2015

Hydrolysis of the title benzothiazinecarboxylates (I) is accompanied by decarboxylation both in acidic and alkaline medium.
ChemInform Abstract: Synthesis of Azepino[4,5‐b]indolones by an Intramolecular Cyclization of Unsaturated Tryptamides.
Authors: Nidhiry John , Prasad Kavirayani R.
Published: March 2015

The seven step synthesis of the starting materials is described.
ChemInform Abstract: Synthesis, Characterization and Antimicrobial Activity of 2‐(11‐Oxodibenzo[b,f][1,4]thiazepin‐10(11H)‐yl)‐N (Substituted Phenyl) Acetamide Derivatives.
Authors: Tailor Jitesh H. , Patel Priti C. , Malik G. M.
Published: March 2015

Most of the title compounds (III) (13 examples) show considerable activity against E.
ChemInform Abstract: The Catalytic Asymmetric Abramov Reaction.
Authors: Guin Joyram , Wang Qinggang , van Gemmeren Manuel , List Benjamin
Published: March 2015

The first enantioselective protocol for the Abramov reaction is described.
ChemInform Abstract: Synthesis of Nor‐sesquiterpene Spirolactones and Their Steroidal Hybrids Revisited. The Neopentyl Dilemma: Misassignment of One Stereocentre May Necessitate a Completely New Approach.
Authors: Safir Imad , Chanu Angeline , Elkhayat Zobida , Basak Ramkrishna , Arseniyadis Simeon
Published: March 2015

The correct C1 configuration in natural pathylactone A (I) is clarified.
ChemInform Abstract: Equisetumone, a Novel 4‐5‐Olide Secocaryophyllane Sesquiterpene from Equisetum palustre
Authors: Fu Yu‐Jie , et al. et al.
Published: March 2015

isolation, structure elucidation and antimicrobial activity
ChemInform Abstract: An Antibacterial 9,11‐Secosterol from a Marine Sponge Ircinia sp.
Authors: Yang Inho , Choi Hyukjae , Won Dong Hwan , Nam Sang‐Jip , Kang Heonjoong
Published: March 2015

isolation and structure of secosterol (I)
ChemInform Abstract: Sequential Biocatalytic Aldol Reactions in Multistep Asymmetric Synthesis: Pipecolic Acid, Piperidine and Pyrrolidine (Homo)Iminocyclitol Derivatives from Achiral Building Blocks.
Authors: Soler Anna , Garrabou Xavier , Hernandez Karel , Gutierrez Mariana L. , Busto Eduardo , Bujons Jordi , Parella Teodor , Joglar Jesus , Clapes Pere
Published: March 2015

Two consecutive enzymatic and asymmetric aldol reactions allow the synthesis of stereodefined pipecolic acid (I), piperidine, and pyrrolidine (homo)iminocyclitol [(II) and (III)] derivatives from dimethoxy acetaldehyde and glycine.
ChemInform Abstract: Forazoline A: Marine‐Derived Polyketide with Antifungal in vivo Efficacy.
Authors: Bugni Tim S. , et al. et al.
Published: March 2015

The polyketide forazoline A is isolated from Actinomadura sp.
ChemInform Abstract: Recent Advances in Asymmetric Organocatalysis Mediated by Bifunctional Amine—Thioureas Bearing Multiple Hydrogen‐Bonding Donors
Authors: Fang Xin , Wang Chun‐Jiang
Published: March 2015

Review: [50 refs.
ChemInform Abstract: Fixation of Sulfur Dioxide into Small Molecules
Authors: Liu Gang , Fan Congbin , Wu Jie
Published: March 2015

Review: [32 refs.
ChemInform Abstract: N‐Phosphonyl/Phosphinyl Imines and Group‐Assisted Purification (GAP) Chemistry/Technology
Authors: An Guanghui , Seifert Cole , Li Guigen
Published: March 2015

Review: [47 refs.
ChemInform Abstract: Phosphine Organocatalysis for the Synthesis of Spirocyclic Compounds
Authors: Voituriez Arnaud , Marinetti Angela , Gicquel Maxime
Published: March 2015

Review: 60 refs.
ChemInform Abstract: A Review of Syntheses of 1,5‐Disubstituted Tetrazole Derivatives
Authors: Sarvary Afshin , Maleki Ali
Published: March 2015

Review: 138 refs.
ChemInform Abstract: Functionalization of Fluorinated Molecules by Transition‐Metal‐Mediated C‐F Bond Activation To Access Fluorinated Building Blocks
Authors: Ahrens Theresia , Kohlmann Johannes , Ahrens Mike , Braun Thomas
Published: March 2015

Review: 474 refs.
ChemInform Abstract: Robust Ruthenium(II)‐Catalyzed C‐H Arylations: Carboxylate Assistance for the Efficient Synthesis of Angiotensin‐II‐Receptor Blockers
Authors: Ackermann Lutz
Published: March 2015

Review: 174 refs.
ChemInform Abstract: Synthetic Applications of Intramolecular Thiol‐Ene ′Click′ Reactions
Authors: Scanlan Eoin M. , Corce Vincent , Malone Aoife
Published: March 2015

Review: recent advances in intramolecular thiyl‐radical mediated reactions and their aplications for synthetic and medicinal chemistry; 49 refs.
ChemInform Abstract: 6‐Deoxyheptoses in Nature, Chemistry, and Medicine
Authors: Pakulski Zbigniew , Poly Frederic , Dorabawila Nelum , Guerry Patricia , Monteiro Mario A.
Published: March 2015

Review: 183 refs.
ChemInform Abstract: Recent Progress in the Field of Glycoconjugates
Authors: Crucho Carina I. C. , Correia‐da‐Silva Paula , Petrova Krasimira T. , Barros M. Teresa
Published: March 2015

Review: 65 refs.
ChemInform Abstract: The Von Auwers Reaction — History and Synthetic Applications
Authors: Dumeunier Raphael , Jaeckh Simon
Published: March 2015

Review: 74 refs.
ChemInform Abstract: Asymmetric Autocatalysis of Pyrimidyl Alkanol and Its Application to the Study on the Origin of Homochirality
Authors: Soai Kenso , Kawasaki Tsuneomi , Matsumoto Arimasa
Published: March 2015

Review: 89 refs.
ChemInform Abstract: Catalytic Diamination of Olefins via N‐N Bond Activation
Authors: Zhu Yingguang , Cornwall Richard G. , Du Haifeng , Zhao Baoguo , Shi Yian
Published: March 2015

Review: 74 refs.
ChemInform Abstract: Mechanistic Insights into Nickamine‐Catalyzed Alkyl‐Alkyl Cross‐Coupling Reactions
Authors: Breitenfeld Jan , Hu Xile
Published: March 2015

Review: 9 refs.
ChemInform Abstract: Writing with Ring Currents: Selectively Hydrogenated Polycyclic Aromatics as Finite Models of Graphene and Graphane
Authors: Fowler Patrick W. , Gibson Christopher M. , Bean David E.
Published: March 2015

Review: 50 refs.
ChemInform Abstract: Stable Carbenes
Authors: Moerdyk Jonathan P. , Bielawski Christopher W.
Published: March 2015

Review: history, key developments, and future directions; 222 refs.
ChemInform Abstract: Site‐Specific Analysis of Amyloid Assemblies by Using Scanning Tunneling Microscopy
Authors: Yu Yue , Yang Yanlian , Wang Chen
Published: March 2015

Review: 67 refs.
ChemInform Abstract: Storing Energy in Plastics: A Review on Conducting Polymers & Their Role in Electrochemical Energy Storage
Authors: Abdelhamid Muhammad E. , O'Mullane Anthony P. , Snook Graeme A.
Published: March 2015

Review: 108 refs.
ChemInform Abstract: Smart Supramolecular Nanosystems for Bioimaging and Drug Delivery
Authors: Yang Peipei , Wang Lei , Wang Hao
Published: March 2015

Review: 61 refs.
ChemInform Abstract: Sweetness and Light: Design and Applications of Photo‐Responsive Glycoconjugates
Authors: Hu Yingxue , Tabor Rico F. , Wilkinson Brendan L.
Published: March 2015

Review: [72 refs.
ChemInform Abstract: Thiazole: A Promising Heterocycle for the Development of Potent CNS Active Agents
Authors: Mishra Chandra Bhushan , Kumari Shikha , Tiwari Manisha
Published: March 2015

Review: 175 refs.
ChemInform Abstract: Sulfated Glycans in Inflammation
Authors: Pomin Vitor H.
Published: March 2015

Review: 131 refs.
ChemInform Abstract: Medicinal Uses, Phytochemistry and Pharmacology of Family Sterculiaceae: A Review
Authors: Al Muqarrabun L.m.r. , Ahmat N.
Published: March 2015

Review: 60 refs.
ChemInform Abstract: Evolution in Medicinal Chemistry of Ursolic Acid Derivatives as Anticancer Agents
Authors: Chen Haijun , Gao Yu , Wang Ailan , Zhou Xiaobin , Zheng Yunquan , Zhou Jia
Published: March 2015

Review: 70 refs.
ChemInform Abstract: Chalcones and Their Therapeutic Targets for the Management of Diabetes: Structural and Pharmacological Perspectives
Authors: Mahapatra Debarshi Kar , Asati Vivek , Bharti Sanjay Kumar
Published: March 2015

Review: 122 refs.
ChemInform Abstract: Electron Transfer in Peptides
Authors: Shah Afzal , Adhikari Bimalendu , Martic Sanela , Munir Azeema , Shahzad Suniya , Ahmad Khurshid , Kraatz Heinz‐Bernhard
Published: March 2015

Review: 76 refs.
Management strategies for hepatitis B–infected patients undergoing immunomodulatory therapy: Is lamivudine enough?
Authors: Terrault Norah
Published: March 2015

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How Many Molecules Does It Take to Tell a Story? Case Studies, Language, and an Epistemic View of Medicinal Chemistry
Authors: Stahl Martin , Baier Sabine
Published: March 2015

Medicinal chemistry has always been closer to the arts than other disciplines in the natural sciences. Instead of searching for natural laws, medicinal chemistry creates new molecular entities entailing desired pharmaceutical characteristics. While the productive output of medicinal chemistry is comprehensively documented, the epistemic paths of the creative process are less well described. Here we show how such paths could be visualized and how these visualizations relate to images developed in the history and philosophy of science. Based on the discussion of these visualizations, we argue that there is a need for a new language of creativity that can be employed during the very course of research, as opposed to its retrospective analysis. This language should be able to reflect both the status and directions in highly complex research processes that may have a clear goal, yet must remain open to unexpected moments of serendipity.
Ovarian cancer prevention: Time for primetime?
Authors: Brawley Otis W.
Published: March 2015

In this issue of Cancer, members of the Society of Gynecologic Oncology review the etiology of ovarian cancer and present the society's recommendations for the prevention of the disease. They call for a concerted effort to identify women at high risk who are most likely to benefit from cancer chemotherapy or surgical prevention.
Time to divest from tobacco‐funded research
Authors: Khuri Fadlo R. , Ramalingam Suresh S.
Published: March 2015

In this editorial, the Editor‐in‐Chief and Section Editor for Chest and Lung Disease explain why Cancer will no longer consider any work that is funded directly or indirectly from tobacco companies or their subsidiaries.
Finite element simulation of the insertion of guidewires during an EVAR procedure: example of a complex patient case, a first step toward patient‐specific parameterized models
Authors: Gindre Juliette , Bel‐Brunon Aline , Kaladji Adrien , Duménil Aurélien , Rochette Michel , Lucas Antoine , Haigron Pascal , Combescure Alain
Published: March 2015

Deformations of the vascular structure due to the insertion of tools during endovascular treatment of aneurysms of the abdominal aorta, unless properly anticipated during the preoperative planning phase, may be the source of intraoperative or postoperative complications. We propose here an explicit finite element simulation method which enables one to predict such deformations. This method is based on a mechanical model of the vascular structure which takes into account the nonlinear behavior of the arterial wall, the prestressing effect induced by the blood pressure and the mechanical support of the surrounding organs and structures. An analysis of the model sensitivity to the parameters used to represent this environment is done. This allows determining the parameters that have the largest influence on the quality of the prediction and also provides realistic values for each of them as no experimental data are available in the literature. Moreover, for the first time, the results are compared with 3D intraoperative data. This is done for a patient‐specific case with a complex anatomy in order to assess the feasibility of the method. Finally, the predictive capability of the simulation is evaluated on a group of nine patients. The error between the final simulated and intraoperatively measured tool positions was 2.1 mm after the calibration phase on one patient. It results in a 4.6 ± 2.5 mm in average error for the blind evaluation on nine patients. Copyright © 2015 John Wiley & Sons, Ltd.
UV Emission of Gd3+ in the Presence of Cu2+: Towards Luminescence Quenching through Quantum Cutting?
Authors: Jiménez José A.
Published: March 2015

The first investigation into the ultraviolet (UV) photoluminescence of gadolinium(III) in the presence of copper(II) is reported. A melt‐quenched barium phosphate glass was used as a model matrix. The optical spectroscopy assessment shows that with increasing CuO concentration the Cu2+ absorption band grows steadily, whereas the UV emission from Gd3+ ions is progressively quenched. The data, thus, suggests the existence of a Gd3+→Cu2+ energy‐transfer process ocurring through quantum cutting. A downconversion/cross‐relaxation pathway proceeding through a virtual state in Gd3+ is proposed. These findings suggest gadolinium(III) could potentially be used in the optical sensing of copper(II).
Suzuki Coupling Reactions Catalyzed by PdO Dispersed on Dealuminated Y Zeolite in Air under Ambient Conditions
Authors: Okumura Kazu , Mushiake Takumi , Matsui Yu , Ishii Akira
Published: March 2015

Suzuki coupling reactions are performed using PdO loaded on dealuminated Y (USY) zeolite. The reaction between bromobenzene and phenylboronic acid is complete in 15 min at room temperature in air, with a turnover number of 1300. The reaction can be repeated at least five times by using 1 wt % Pd. Inductively coupled plasma analysis does not reveal the dissolution of Pd from products, even if the reaction is repeated up to four times. Pd K‐edge extended X‐ray absorption fine structure analysis reveals the presence of molecular‐like PdO and a mixture of Pd0–PdO before and after the reaction, respectively. This is probably because Pd stabilized by Al sites is present at the II sites of the Y‐type zeolite, as estimated using first‐principles calculations. Conversely, Pd species change to PdO clusters after repeated reactions in air using the thermally treated sample.
A Trait‐based framework for mutation bias as a driver of long‐term evolutionary trends
Authors: Xue Julian Z. , Costopoulos André , Guichard Frédéric
Published: March 2015

Previous work has shown that mutation bias can direct evolutionary trends in genotypic space under strong selection and rare mutation. We present an extension of this work to general traits of the organism. We do this by allowing many different genotypes, with different fitnesses, to have the same trait value. This approach makes novel predictions and shows that the outcome of evolution for a trait is influenced by mutation bias as well as the fitness distribution of the genotypes that have the same trait value. This distribution can alter evolution in interesting ways, depending on the likelihood of generating high fitness mutants. We also show that mutation bias can direct evolution when many mutants are present at any one time. We demonstrate that mutation bias can drive long‐term evolutionary trends when the environment is constantly changing. Under biologically realistic conditions, we show that mutation bias can counter strong gradients of environmental selection over time. We conclude that evolutionary trends can be quite independent of the environment, even when they depress population fitness. Finally, we show that entropy can be a powerful source of mutation bias and can drive evolutionary trends. © 2015 Wiley Periodicals, Inc. Complexity 21: 331–345, 2016
The complexity of binary sequences using logistic chaotic maps
Authors: Liu Lingfeng , Miao Suoxia
Published: March 2015

The information sources using logistic maps have been studied in this article. We use a particular symmetric binary function to generate the binary sequences due to the generating partition of the logistic maps, which can reflect the dynamics of chaotic real‐valued sequences. Using this binary function, we will establish a binary description of the logistic maps, and prove that this description is equivalent with the logistic maps. The probability of all the possible binary sequences generated by this symmetric binary function has been calculated according to this description. Furthermore, the cryptographic complexity of these binary sequences is evaluated theoretically and experimentally, including the correlation functions, the linear complexity, the nonlinear complexity, the Lempel–Ziv complexity and the approximate entropy. Such results show that the logistic binary sequences have good properties of cryptography. © 2015 Wiley Periodicals, Inc. Complexity 21: 121–129, 2016
The Relationship between Theoretical Orientation and Countertransference Expectations: Implications for Ethical Dilemmas and Risk Management
Authors: Gordon Robert M. , Gazzillo Francesco , Blake Andrea , Bornstein Robert F. , Etzi Janet , Lingiardi Vittorio , McWilliams Nancy , Rothery Cheryll , Tasso Anthony F.
Published: March 2015

Countertransference (CT) awareness is widely considered valuable for differential diagnosis and the proactive management of ethical dilemmas. We predicted that the more practitioners' theoretical orientation (TO) emphasizes insight into the dynamics of subjective mental life, the better they will be at using their CT expectations in differential diagnosis with high‐risk patients. To test this hypothesis, we compared psychodynamic therapy (PDT) practitioners who emphasize insight into subjective mental life with practitioners who do not emphasize this epistemology. Results indicated that PDT practitioners expected significantly more CT than practitioners of cognitive–behavioural therapy (CBT) and other practitioners (e.g., family systems, humanistic/existential and eclectic) to patients with borderline personality organization overall. PDT practitioners had significantly more CT expectations to patients with borderline‐level pathologies as compared with neurotic‐level patients than both CBT and other practitioners. PDT practitioners were significantly more expectant of CT issues than CBT practitioners with respect to the personality disorders most associated with acting out and risk management problems (e.g., paranoid, psychopathic, narcissistic, sadistic, sadomasochistic, masochistic, hypomanic, passive–aggressive, counterdependent and counterphobic). The other practitioners generally had CT expectations between PDT and CBT. These findings suggest that clinical training into CT may be useful in differential diagnoses and in helping to avoid ethical dilemmas regardless of one's theoretical preference. Copyright © 2015 John Wiley & Sons, Ltd.

Key Practitioner Message

Insight into countertransference can be used to help with differential diagnoses and to help prevent possible management problems with acting out patients. The Psychodynamic Diagnostic Manual is a useful taxonomy in that it includes countertransference as a diagnostic aid.
Tailoring the Properties of Ammine Metal Borohydrides for Solid‐State Hydrogen Storage
Authors: Jepsen Lars H. , Ley Morten B. , Filinchuk Yaroslav , Besenbacher Flemming , Jensen Torben R.
Published: March 2015

A series of halide‐free ammine manganese borohydrides, Mn(BH4)2⋅nNH3, n=1, 2, 3, and 6, a new bimetallic compound Li2Mn(BH4)4⋅6NH3, and the first ammine metal borohydride solid solution Mg1−xMnx(BH4)2⋅6NH3 are presented. Four new crystal structures have been determined by synchrotron radiation powder X‐ray diffraction and the thermal decomposition is systematically investigated for all the new compounds. The solid‐gas reaction between Mn(BH4)2 and NH3 provides Mn(BH4)2⋅6NH3. The number of NH3 per Mn has been varied by mechanochemical treatment of Mn(BH4)2⋅6NH3‐Mn(BH4)2 mixtures giving rise to increased hydrogen purity for n/m≤1 for M(BH4)m⋅nNH3. The structures of Mg(BH4)2⋅3NH3 and Li2Mg(BH4)4⋅6NH3 have been revisited and new structural models are presented. Finally, we demonstrate that ammonia destabilizes metal borohydrides with low electronegativity of the metal (χp<∼1.6), while metal borohydrides with high electronegativity (χp>∼1.6) are generally stabilized.
A phase synchronization control scheme for LCL‐T type high‐frequency current source in parallel connection
Authors: Zeng Jun , Liu Junfeng , Yang Jinming , Luo Fei , Cheng K. W. Eric.
Published: March 2015

Considering the applications of high voltage gate driving system and contactless power transmission, a current‐based power distribution is adopted as a kind of replacement of voltage based high‐frequency Alternating Current (AC) power distribution system. In order to implement high‐frequency current source, an LCL‐T resonant inverter is examined with constant current characteristic and high conversion efficiency. First, the resonant topology is studied as a high‐frequency power source, including circuit principle, operational cycle analysis, and AC analysis. The effective control and high conversion efficiency are both achieved by LCL‐T resonant inverter. Second, the phase angle control scheme is explored to improve the synchronization performance in parallel system formed by multiple of LCL‐T resonant inverters. Lastly, a prototype of parallel system is evaluated by simulation and experiment results, both of which are constructed by two resonant inverters with rated peak current of 2 A, rated output frequency of 30 kHz, and rated output power of 100 W. The experimental results in accordance with simulation prove that the better phase synchronization of output currents is achieved by the phase angle control. Hence, the high‐frequency resonant topology and phase control scheme are a feasible realization of current source that can be used to feed current‐based high‐frequency power distribution system. Copyright © 2015 John Wiley & Sons, Ltd.

Index Terms—high‐frequency AC (HFAC), power distribution system (PDS), LCL‐T resonant inverter, current source, phase angle control.
Design of ultra low‐power RF oscillators based on the inversion coefficient methodology using BSIM6 model
Authors: Guitton G. , Mangla A. , Chalkiadaki M.‐A. , Fadhuile F. , Taris T. , Enz C.
Published: March 2015

This paper presents a fast and accurate way to design and optimize LC oscillators using the inversion coefficient (IC). This methodology consists of four steps: linear analysis, nonlinear analysis, phase noise analysis, and optimization using a figure of merit. For given amplitude of oscillation and frequency, we are able to determine all the design variables in order to get the best trade‐off between current consumption and phase noise. This methodology is demonstrated through the design of Pierce and cross‐coupled oscillators and has been verified with BSIM6 metal oxide semiconductor field effect transistor compact model using the parameters of a commercial advanced 40 nm complementary metal oxide semiconductor process. Copyright © 2015 John Wiley & Sons, Ltd.
Cerebellar granule cells are predominantly generated by terminal symmetric divisions of granule cell precursors
Authors: Nakashima Kie , Umeshima Hiroki , Kengaku Mineko
Published: March 2015

Background: Neurons in the central nervous system (CNS) are generated by symmetric and asymmetric cell division of neural stem cells and their derivative progenitor cells. Cerebellar granule cells are the most abundant neurons in the CNS, and are generated by intensive cell division of granule cell precursors (GCPs) during postnatal development. Dysregulation of GCP cell cycle is causal for some subtypes of medulloblastoma. However, the details and mechanisms underlying neurogenesis from GCPs are not well understood. Results: Using long‐term live‐cell imaging of proliferating GCPs transfected with a fluorescent newborn‐granule cell marker, we found that GCPs underwent predominantly symmetric divisions, generating two GCPs or two neurons, while asymmetric divisions generating a GCP and a neuron were only occasionally observed, in both dissociated culture and within tissues of isolated cerebellar lobules. We found no significant difference in cell cycle length between proliferative and neurogenic divisions, or any consistent changes in cell cycle length during repeated proliferative division. Conclusions: Unlike neural stem cells in the cerebral cortex and spinal cord, which generate many neurons by repeated asymmetric division, cerebellar GCPs produce neurons predominantly by terminal symmetric division. These results indicate diverse mechanisms of neurogenesis in the mammalian brain. Developmental Dynamics 244:748–758, 2015. © 2015 Wiley Periodicals, Inc.
Controlled expression of Drosophila homeobox loci using the Hostile takeover system
Authors: Javeed Naureen , Tardi Nicholas J. , Maher Maggie , Singari Swetha , Edwards Kevin A.
Published: March 2015

Background: Hostile takeover (Hto) is a Drosophila protein trapping system that allows the investigator to both induce a gene and tag its product. The Hto transposon carries a GAL4‐regulated promoter expressing an exon encoding a FLAG‐mCherry tag. Upon expression, the Hto exon can splice to a downstream genomic exon, generating a fusion transcript and tagged protein. Results: Using rough‐eye phenotypic screens, Hto inserts were recovered at eight homeobox or Pax loci: cut, Drgx/CG34340, Pox neuro, araucan, shaven/D‐Pax2, Zn finger homeodomain 2, Sex combs reduced (Scr), and the abdominal‐A region. The collection yields diverse misexpression phenotypes. Ectopic Drgx was found to alter the cytoskeleton and cell adhesion in ovary follicle cells. Hto expression of cut, araucan, or shaven gives phenotypes similar to those of the corresponding UAS‐cDNA constructs. The cut and Pox neuro phenotypes are suppressed by the corresponding RNAi constructs. The Scr and abdominal‐A inserts do not make fusion proteins, but may act by chromatin‐ or RNA‐based mechanisms. Conclusions: Hto can effectively express tagged homeodomain proteins from their endogenous loci; the Minos vector allows inserts to be obtained even in transposon cold‐spots. Hto screens may recover homeobox genes at high rates because they are particularly sensitive to misexpression. Developmental Dynamics 244:808–825, 2015. © 2015 Wiley Periodicals, Inc.
Human tolerogenic dendritic cells produce IL‐35 in the absence of other IL‐12 family members
Authors: Dixon Karen O. , van der Kooij Sandra W. , Vignali Dario A. A. , van Kooten Cees
Published: March 2015

IL‐35 is a cytokine of the IL‐12 family, existing as a heterodimer of IL‐12p35 and Ebi3. IL‐35 has anti‐inflammatory properties and is produced by regulatory T cells in humans and mice, where it is required for optimal suppression of immune responses. Distinct from other IL‐12 cytokines, the expression of IL‐35 has not been described in antigen‐presenting cells. In view of the immune‐regulatory properties of IL‐35, we investigated the expression, regulation, and function of IL‐12p35 and Ebi3 in human monocyte‐derived dendritic cells and tolerogenic DCs (tolDCs). These tolDCs do not produce IL‐12p70 or the homodimer IL‐12p40. We demonstrate that tolDCs completely lack transcriptional expression of IL‐12p40. However, tolDCs maintain mRNA expression of IL‐12p35 and Ebi3. Using intracellular flow cytometry and Western blot analysis, we show that tolDCs produce Ebi3 and IL‐12p35, and both can be enhanced upon stimulation with IFN‐γ, LPS, or CD40L. tolDCs supernatants have the capacity to suppress T‐cell activation. Using IL12A silencing, we demonstrate that IL‐12p35 is required for tolDCs to reach their full suppressive potential. Taken together, our results indicate that tolDCs produce IL‐35, providing an additional novel mechanism by which tolDCs elicit their tolerogenic potential.