bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of TP53 Mutation Status and Sex with Clinical Outcome in Non–Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors: A Retrospective Cohort Study
Authors: Choi Songji , Kim Se Hyun , Lee Sejoon , Seo Jeongmin , Kang Minsu , Jung Eun Hee , Kim Sang-A , Suh Koung Jin , Lee Ji Yun , Kim Ji-Won , Kim Jin Won , Lee Jeong-Ok , Kim Yu Jung , Lee Keun-Wook , Kim Jee Hyun , Bang Soo-Mee , Lee Jong Seok
Published: August 2024

Purpose Some studies suggest that TP53 mutations are associated with the response to immune checkpoint inhibitors (ICI) in patients with non–small cell lung cancer (NSCLC) and also contribute to sex disparities in several cancers. Thus, we hypothesized that TP53 mutations might serve as sex-dependent genomic biomarkers of ICI treatment response in patients with NSCLC.Materials and Methods Clinical data of 100 patients with metastatic NSCLC treated with ICI monotherapy at Seoul National University Bundang Hospital (SNUBH) were retrospectively reviewed. Genomic and clinical datasets of The Cancer Genome Atlas and an ICI-treated lung cancer cohort (cBioPortal) were also analyzed.Results In SNUBH cohort, no statistically significant difference was observed in the median progression-free survival (PFS) according to TP53 mutation status (p=0.930); however, female patients with TP53 mutations (MT) had a significantly prolonged median PFS compared to wild-type (WT) (6.1 months in TP53 MT vs. 2.6 months in TP53 WT; p=0.021). Programmed death-ligand 1 (PD-L1) high (≥ 50%) expression was significantly enriched in female patients with TP53 MT (p=0.005). The analysis from publicly available dataset also revealed that females with NSCLC with TP53 MT showed significantly longer PFS than those with TP53 WT (p < 0.001). In The Cancer Genome Atlas analysis, expression of immune-related genes, and tumor mutation burden score in TP53 MT females were higher than in males without TP53 MT.Conclusion Female patients with NSCLC with TP53 mutations had high PD-L1 expression and showed favorable clinical outcomes following ICI therapy, suggesting a need for further research to explore the role of TP53 mutations for sex disparities in response to ICI therapy.
$L^{2}$-cohomology and quasi-isometries on the ends of unbounded geometry
Authors: Spessato Stefano
Published: August 2024

The paper explores the minimal and maximal

L^{2}

-cohomology of oriented Riemannian manifolds, focusing on both the reduced and the unreduced versions. The main result is the proof of the invariance of the

L^{2}

-cohomology groups under uniform homotopy equivalences that are quasi-isometric on the unbounded ends. A
uniform map
is a uniformly continuous map such that the diameter of the preimage of a subset is bounded in terms of the diameter of the subset itself. Moreover, a map

f

between two Riemannian manifolds

(X,g)

and

(Y,h)

is
quasi-isometric on the unbounded ends
if

X = M \cup E_{X}

, where

M

is the interior of a manifold of bounded geometry with boundary,

E_{X}

is an open subset of

X

and the restriction of

f

to

E_{X}

is a quasi-isometry. Finally, some consequences are shown: the main ones are the definition of a mapping cone for

L^{2}

-cohomology and the invariance of the

L^{2}

-signature.
Lipschitz continuity of the metric projection operator and convergence of gradient methods
Authors: Balashov Maxim Viktorovich
Published: August 2024

Various support conditions for a closed subset of a real Hilbert space $\mathcal H$ at a boundary point of this set are considered. These conditions ensure certain local Lipschitz continuity of the metric projection operator as a function of a point. The local Lipschitz continuity of the metric projection as a function of the set in the Hausdorff metric is also proved. This Lipschitz property is used to verify the linear convergence of some gradient methods (the gradient projection method and the conditional gradient method) without assuming that the function must be strongly convex (or even convex) and for not necessarily convex sets. The function is assumed to be differentiable with Lipschitz continuous gradient.
Bibliography: 29 titles.
Targeting colorectal cancer with Herba Patriniae and Coix seed: Network pharmacology, molecular docking, and in vitro validation
Authors: Wang Cheng-Lei , Yang Bing-Wei , Wang Xin-Yan , Chen Xue , Li Wei-Dong , Zhai Hao-Yu , Wu Ying , Cui Mu-Yao , Wu Jia-He , Meng Qing-Hui , Zhang Nan
Published: August 2024

BACKGROUND

Herba Patriniae and Coix seed (HC) constitute a widely utilized drug combination in the clinical management of colorectal cancer (CRC) that is known for its diuretic, anti-inflammatory, and swelling-reducing properties. Although its efficacy has been demonstrated in a clinical setting, the active compounds and their mechanisms of action in CRC treatment remain to be fully elucidated.

AIM

To identify the active, CRC-targeting components of HC and to elucidate the mechanisms of action involved.

METHODS

Active HC components were identified and screened using databases. Targets for each component were predicted. CRC-related targets were obtained from human gene databases. Interaction targets between HC and CRC were identified. A “drug-ingredient-target” network was created to identify the core components and targets involved. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted to elucidate the key pathways involved. Molecular docking between core targets and key components was executed. In vitro experiments validated core monomers.

RESULTS

Nineteen active components of HC were identified, with acacetin as the primary active compound. The predictive analysis identified 454 targets of the active compounds in HC. Intersection mapping with 2685 CRC-related targets yielded 171 intervention targets, including 30 core targets. GO and KEGG analyses indicated that HC may influence the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. Molecular docking showed that acacetin exhibited an optimal interaction with AKT1 , identifying PI3K , AKT , and P53 as key genes likely targeted by HC during CRC treatment. Acacetin inhibited HT-29 cell proliferation and migration, as well as promoted apoptosis, in vitro . Western blotting analysis revealed increased p53 and cleaved caspase-3 expression and decreased levels of p-PI3K , p-Akt , and survivin, which likely contributed to CRC apoptosis.

CONCLUSION

Acacetin, the principal active compound in the HC pair, inhibited the proliferation and migration of HT-29 cells and promoted apoptosis through the PI3K/Akt/p53 signaling pathway.
Mapping of IgE cross-reactivity of Gly m 4, Gly m 5 and Gly m 6 soybean allergens in patients with atopic diseases
Authors: Samoylikov Pavel V. , Vasilyeva G. V. , Konanykhina S. Y. , Poddubikov A. V.
Published: August 2024

Currently, a significant portion of the food consists of multiple different ingredients. Soybean proteins have been widely used for production of these combined foodstuffs. Meanwhile, soy proteins may contain a wide range of allergens, and even, if present in small amounts, they can cause severe allergic reactions due to cross-reactivity. The aims of our study were to evaluate the prevalence of sensitization to soybean allergen components Gly m 4, Gly m 5 and Gly m 6, and to map their IgE cross-reactivity with homologous proteins of Bet v1-like proteins and cupin proteins in patients with atopic disorders. We have studied IgE’s to 112 allergenic components of plant and animal origin in blood sera from 54 patients with history of allergy, using the ImmunoCap ISAC method. The results were analyzed by means of MS Excel program using parametric statistical criteria. Results: In patients with atopic diseases, we have detected serum IgE to the rGly m 4 allergic component (5 patients out of 29; 17.24%). Frequency of sIgE detection to rGly m 5 (3 patients of 29; 10.24%) and rGly m 6 (1 patient of 29; 3.44%) was less pronounced. Cross-reactive sIgE was detected only to allergens of the Bet v1 superfamily. The strongest relationship was found between sIgE level to rGly m 4 and rBet v1 (R = 0.68; p = 0.001). Another IgE cross-reaction was found between soybean rGly m 4 and alder pollen rAln g1 (R = 0.681; p = 0.000). IgE antibodies to rGly m 4 may also cross-react with kiwi rAct d8 (R = 0.59; p = 0.001). We have also found a weak correlation between sIgE to soybean rGly m 4 and two hazelnut rCor a1 isoforms: rCor a 1.01 (R = 0.42; p = 0.023), and rCor a 1.04 (R = 0.39; p = 0.036). The IgE cross-reactivity profile of the soy allergens revealed in this study is important for improvement of testing strategy for the presence of causally significant allergens. This finding will help to avoid the development of hidden cross-reactions that trigger both oral and respiratory allergic processes in subjects with allergic pathology. Moreover, this will enable administration of optimal diets and develop technologies for development of hypoallergenic food products.
Diyabetik Retinopati Tespiti İçin Derin Öğrenmeye Dayalı Sınıflandırma
Authors: Polater Seda Nur , Isık Ali Hakan
Published: August 2024

Diyabetik Retinopati (DR), yüksek kan şekeri seviyelerinin retinadaki kan damarlarında neden olduğu hasar sonucu oluşan bir göz hastalığıdır. Bu hastalık, erken teşhis edilmediği ve tedavi edilmediği durumlarda ciddi göz sorunlarına ve görme kaybına yol açabilir. Genellikle kan şekeri kontrolü ve erken tedavi ile bu komplikasyonlar önlenebilir, ancak DR'nin karmaşıklığı nedeniyle manuel teşhis zorlu olabilir. Uzmanlar, bu tür zorlu teşhislerde Evrişimsel Sinir Ağları (ESA) gibi derin öğrenme modellerinin başarılı bir şekilde kullanıldığını göstermişlerdir. Bu çalışma, DR'nin teşhisi ve sınıflandırılması üzerine makine öğrenme algoritmaları kullanılarak tamamlanmıştır. Araştırma, Aptos 2019 veri setini kullanarak gerçekleştirilmiştir. Bu veri seti, farklı DR şiddetlerine sahip retina görüntülerini içermektedir, bu da "Proliferatif," "Şiddetli," "Orta," "Hafif," ve "Diyabetik retinopati yok" gibi sınıflandırmaları içerir. Hastalığın teşhisi için DenseNet121, MobileNetV2, DenseNet169, InceptionV3, VGG16, MobileNet, VGG19, ResNet50, ResNet101 modelleri kullanılmıştır. DenseNet121 modelinde %97 doğruluk değeri hesaplanmıştır.
Communication, society, and media in a hyper-globalizing context: A multidisciplinary and cross-historical perspective
Authors: Branea Silvia
Published: August 2024

The thematic focus of the present issue is represented by the nexus of “communication – society – media,” all represented here by the digital condition, which has become a sine-qua-non characteristic of nowadays increasingly technologized society. The publications reflect an array of topics and a diversity of methodological approaches and contributors. These factors enrich the academic potential and social contribution of this collection.
Gender Stereotypes in Digital Advertising Case study: L'Oréal
Authors: Branea Silvia , Stoica Diana
Published: August 2024

This paper briefly presents the image of gender stereotypes in media and also in advertising and, respectively, digital advertising. The purpose is to observe if nowadays famous beauty brands (in this case - L'Oréal) still use gender stereotypes in the materials published online, on different social media platforms (in this case – Instagram). Throughout the research questions, the authors discover if there are any gender stereotypes present in the selected corpus, which are the strategies used to spread these stereotypes, and which are the roles played by women and men in the posts. In terms of methodology, two will be used two approaches, adapted to the purpose of this study: first, the coding scheme provided by Goffman (1979) and Butkowski et al. (2019), for photos, and secondly, for videos, the coding scheme elaborated by Dominick & Rauch (1972) and revised by Aramendia-Muneta et al. (2019).
Digital Communication in Japanese Companies: The Corporate Blog. Current Trends, Challenges, and Future Perspectives
Authors: Irina Pelea Cringuta
Published: August 2024

The present article examines the digital communication patterns exerted by domestic Japanese companies through Japanese-language blogging practices: main characteristics, current trends, challenges, and future tendencies at the intersection of Japanese corporate culture, communication, and the digital realm. After a concise literature review of Japanese corporate identity and predominant cultural features of Japanese management, we will conduct a qualitative content analysis on a selected corpus of Japanese language corporate blogs to investigate the digital corporate discourse (content, types of public, communication strategies, and techniques) on a national level and to inquire into the extent of the impact exerted by the digital evolution of media platforms and the emergence of new AI tools. The implications of the present research are twofold. First, the database we manually compiled contains only Japanese language sources, thus surpassing the linguistic barrier many Western academics confront when researching Asian countries and media content in Asian languages. Examining the Japanese language digital discourse of domestic companies in a post-pandemic globalized context bridges the unceasing gap between the West and the East, thus decentring the focal point from the Western companies and shifting the attention from English-language digital communication. Second, connecting the Japanese-language business discourse with domestic blogging platforms represents another aspect of particular importance neglected by previous research.
Changes in Organizational Communication since ChatGPT AI Usage in Romania for internal and external corporate communication
Authors: Razec Ines
Published: August 2024

Since their apparition, Large Language Models have been highly used by both individuals and companies for a plethora of personal and professional activities. Considering its capacity of generating text, using large amounts of data available as well as its accessibility, ChatGPT proves to be a useful tool for internal and external communication within companies worldwide. This paper focuses on exploring the changing dynamics in terms of information diffusion between managers, employees, colleagues, and stakeholders within international corporations, with a particular emphasis on the European and American research conducted in the last two years and the personal experiences of ten Romanian managers that use language models in their professional activities and communication. The results show a direct correlation between the usage of ChatGPT to convey important information or assign tasks to the employees, and their augmented productivity, due to better time management and an increased clarity of the delivered messages. While oral communication still plays an important role in establishing personal relationships at the workplace, the written one, facilitated by virtual platforms, is gaining more popularity. This study aims to be a starting point for any future, in-depth analysis of the changing communication organizational dynamics in Romania.
The Digitalization of Personnel Recruiting in Romania During the COVID-19 pandemic
Authors: Marinescu Valentina
Published: August 2024

The existing literature argued that online recruitment is the future, assessing that online interviews will be appreciated by both recruiters and candidates. The central aim of the paper is to analyze the changes made possible by the COVID-19 pandemic in the recruitment process. The research method used in this article was the individual interviews made on a sample of six former candidates for a job who made an online interview in the last year and four recruiters from Human Resources companies. Three research hypotheses were tested in the research project and only two were confirmed by the data. The results showed that candidates who apply for certain positions prefer that the recruitment interviews be conducted via the Internet because they consider that as an easily accessible means. On the other hand, the results stressed the fact that recruiters declared that they prefer to make face-to-face interviews, the argument for this option being that offline interviews allowed them to create a connection with the candidates and enabled them to analyze the non-verbal behaviors of the candidates. As regards the future of recruiting this is uncertain now and only the passing of time could tell us if the digitalization will succeed or not.
The Impact of Social Media on the Involvement of Palestinian Arab Women in the Labor Market in the State of Israel
Authors: Ahmad Redan Abu
Published: August 2024

The current article aims to shed light on the impact of social networking sites on Palestinian women in the State of Israel. It began researching the extent of women's involvement in work, the consequences of women's work, and the obstacles they face in the labor market. Then it highlighted the impact that social media has had on the labor market in general, and then the effects of social media on women’s work in particular. Finally, it highlights the impact of social media on the work of Palestinian women in Israel, and how these sites helped them gain income and self-realization in addition to education and awareness, all from within their homes.
Les strategies narratives dans le texte néo-dramatique „Pierre et Mohamed” d’Adrien Candiard
Authors:   University of Arts Târgu Mureş, Abou Soughaire Tarik
Published: August 2024

The study of the narration-scene interaction has today reached a remarkable place within theatrical studies insofar as it allows researchers, as well as theater people, to touch closely how the roots of the genre are evolving greatly while responding to new demands, as well as new parameters that vary according to practices, cultures, and even eras. Through this research and while focusing on the show entitled “Pierre et Mohamed”, written by Adrian Candiard and published in 2018, we will see to what extent diegesis takes place over mimesis, how speech prevails over dramatic action, or to put it better how orality retreats before narrativity. Hence, it is to be noted that theatricality has evolved and that the founding bases of the genre have been transformed while allowing the theater to renew itself and to derive from it new dramatic types such as what is currently called neo-drama.
Pervivència i memòria de Maria Josepa Massanés: la creació d’una imatge
Authors: Tomàs Margalida
Published: August 2024

This article analyses the various paths that, over the decades between her death and the Second Spanish Republic, led to Josepa Massanés (1811–1887) enjoying a posthumous fame uncommon among nineteenth-century women writers, thanks in no small part to Massanés’s own efforts to construct and preserve her own legacy. Examination of the evolution in interpretations and, most importantly, assessments made by different intellectuals over this period produces a complex and multifaceted vision of her significance as a writer in Spanish and Catalan: from the first of the 19th-century Spanish women poets to a core figure in the Renaixença and even a feminist pioneer. Among these, it is, above all, Dolors Monserdà who will be seen to have worked the hardest to keep Massanés’s memory alive, modifying the picture she painted of the writer to suit changing times.
ESTATUTO DE ANDALUCÍA. NOVEDADES RESPECTO DEL ESTATUTO DE 1981. LA NUEVA CONFIGURACIÓN DEL DERECHO AUTONÓMICO DE ANDALUCÍA
Authors: BALAGUER CALLEJÓN FRANCISCO , CÁMARA VILLAR GREGORIO , MONTILLA MARTOS JOSÉ ANTONIO
Published: August 2024

Presentación de las novedades que el Estatuto de 2007 incorpora en relación con nuestro anterior marco normativo básico. Se encuentra estructurada esta obra en capítulos breves configurados como módulos temáticos por unidad propia sistemática del Estatuto. Finalizan los autores con cuadros finales que ayudan a ofrecer una impresión global introductora o conclusiva del Estatuto de 2007.
Reversal Learning in Ant Colonies
Authors: Sanabria Federico , Santos Cristina , Rajagopal Supraja , Sasaki Takao
Published: August 2024

Reversal learning has been studied in many species, often as an indicator of their behavioral flexibility. Although this research typically focuses on individuals, groups of social animals, especially social insects, are often considered to have similar learning capabilities. Associative learning has been rarely studied in ant colonies and their behavioral flexibility is still to be assessed. In this study, ant colonies readily learned to discriminate between compound visuotactile cues and subsequently learned their reversal. Reversal performance was maintained after a 5-day retention interval, but not after a 10-day interval. Although this study does not differentiate learning processes at the individual vs. colony levels, it is the first demonstration of reversal learning conducted in ant colonies. These results show that the two-corridor maze can serve to assess colony-level learning in ants. This is a first step to investigate key mechanisms underlying collective learning and cognition in ants.
A Case Study of Spontaneous Category Formation and Behavioral Expression in a Language-Trained Steller Sea Lion Eumetopias jubatus
Authors: Sasaki Masahiro , Kambara Toshimune
Published: August 2024

The purpose of this study was to examine the responses of a Steller sea lion to two consecutive commands. We conducted this study on one same subject, Hama, as a continuation of Sasaki et al. (2022), which examined whether the Steller sea lion can discriminate human vocal commands. In Sasaki et al. (2022), commands were presented individually to examine the accuracy rate for each command. In the present study, we observed how Hama responded to the rapid presentation of two consecutive commands. The commands were presented in 20 different orders and combinations as 20 command combination patterns using five different commands. The results showed that Hama responded to 12 command combination patterns by performing behaviors corresponding to two consecutive commands. Hama performed the two behaviors in sequence in 8 of the 12 command combination patterns. The responses to the other four command combination patterns were combined single behaviors that combined the behaviors indicated by the two consecutive commands and that were already connected to different single commands. Although the combined single behaviors were not simple combinations of behaviors induced by the two consecutive commands, the combined single behaviors included the common body parts (e.g., fore flippers) or common action types (e.g., rotation) of behaviors induced by each command in the two consecutive commands. These results not only indicate that Hama could understand multiple linguistic information, but also suggest the possibility that Hama spontaneously formed categories based on the learned commands.
GELİŞMİŞ GLİKASYON SON ÜRÜNLERİ VE SAĞLIK ÜZERİNE ETKİSİ
Authors: Korkmaz Yonca , Gücükoğlu Ali
Published: August 2024

Gelişmiş glikasyon son ürünleri, amino asitlerinin, peptidlerin, proteinlerin ve ketonların normal sıcaklıkta veya ısıl işlem görmüş koşullarda bir dizi kimyasal reaksiyonuyla oluşur. Gıdalar ısıl işlem gördüğünde, Maillard reaksiyonu vasıtasıyla büyük miktarda gelişmiş glikasyon son ürünleri ortaya çıkar. Söz konusu gıdalar tüketildiğinde, gelişmiş glikasyon son ürünleri sindirim ve emilim yoluyla biyolojik aktivite kazanır ve tüm doku ve organlarda birikir. Gıdalarda oluşan gelişmiş glikasyon son ürünleri varlığı ve bunların tüketilmesiyle oluşan halk sağlığı riskleri oldukça dikkat çekmektedir. Yapılan çalışmalarda; diyabet, diyabete bağlı böbrek yetmezliği, diyabetik retinopati, kardiyovasküler hastalıklar, damar komplikasyonları, osteoporoz ve alzheimer gibi kronik hastalıkların oluşumu gıdalarla gelişmiş glikasyon son ürünleri alımı ile ilgili yakından ilişkili olduğunu gösterilmektedir.
Particulate Matter Capture and Air Pollution Tolerance of Six Roadside Plants in Cheongju, South Korea
Authors:   Chungbuk National University, Huong-Thi Bui , Jeong Moonsun , Park Bong-Ju
Published: August 2024

Particulate matter (PM), a highly hazardous air pollutant with known adverse health effects, has been proven to be effectively mitigated by using plants. This study aimed to evaluate the capacity of various plants in capturing PM and their tolerance to air pollution. This will facilitate the selection of suitable species for roadside planting. Accordingly, this research quantified the accumulation of particulate matter in six different plant species. Four biochemical parameters [total chlorophyll, leaf pH extract, relative water content, and ascorbic acid] were evaluated to determine the Air Pollution Tolerance Index (APTI), PM accumulation results varied among the plant species. The tolerance level was categorized into four groups: tolerant, moderately tolerant, intermediate, and sensitive. Ligustrum obtusifolium demonstrated the highest PM accumulation and tolerance index values. The presence of leaf hair and roughness on leaf surfaces was observed to facilitate higher PM accumulation in certain plants. PM accumulation on leaves was significantly correlated with biochemical parameters and APTI of plants. Based on these outcomes, Ligustrum obtusifolium, Hibiscus syriacus, and Chamaecyparis obtusa were identified as suitable for roadside planting to mitigate atmospheric particulate matter.
Pengembangan E-Modul Instalasi Mikrotik Berbasis Android Pada Mata Pelajaran Administrasi Infrastruktur Jaringan Di SMK
Authors: Mukhson Muh. Anis , Untari Rahmania Sri
Published: August 2024

Menurunnya semangat belajar pada siswa yang terjadi saat ini, Hal ini disebabkan oleh tidak efektifnya guru dalam menyampaikan materi dan sumber belajar kepada siswanya, mengakibatkan tingginya kebutuhan terhadap modul elektronik. Penulis terinspirasi untuk membuat media pembelajaran sebagai sumber ajar modul elektronik (e-modul), salah satu jenis bahan ajar pada mata pelajaran Administrasi Infrastruktur Jaringan Kelas XI Teknik computer dan jaringan, dengan semakin pesatnya kemajuan ilmu pengetahuan dan teknologi. Metode yang digunakan dalam penelitian ini adalah R&D (Research and Development) dengan pendekatan pendekatan model ADDIE. Hasil dari penelitian yang dilakukan adalah berupa modul elektronik (e-modul) instalasi mikrotik berbasis android dengan menggunakan perangkat lunak software Ispring Suite 9, Ms. Power Point 2016 dan di konversi agar bisa dijalankan di android dengan Website 2 APK Builder, uji kelayakan modul elektronik ini menggunakan uji dari ahli media yang mendapat presentase sebesar 84% dengan kriteria “Sangat Baik”, ahli materi mendapatkan presentase kelayakan sebesar 92% dengan kriteria “Sangat Baik, kemudian untuk uji kelompok kecil mendapat presentase kelayakan 91,6% dengan kriteria “Sangat Baik”. Sehingga dapat disimpulkan bahwa e-modul instalasi mikrotik untuk siswa kelas XI Jurusan Teknik Komputer dan Jaringan dinyatakan valid, praktis dan sangat efektif digunakan sebagai media pembelajaran praktikum instalasi mikrotik.
Rancang Bangun Sistem Informasi Penjualan Pakan Ternak Berbasis Web Menggunakan Framework Laravel
Authors: Kurniawati Indah , Eviyanti Ade
Published: August 2024

Dalam konteks kemajuan teknologi yang semakin cepat, sangat penting bagi entitas bisnis untuk mengadopsi komputerisasi untuk mengurangi atau menghilangkan keterlambatan, kesulitan, dan ketidakefisienan yang melekat dalam proses manajemen informasi tradisional. Hal ini terlihat dalam metode konvensional yang masih digunakan dalam pembelian dan penjualan pakan hewan, yang tidak memenuhi tuntutan layanan pelanggan modern. Untuk mengatasi tantangan ini, sebuah sistem informasi penjualan pakan hewan dikembangkan menggunakan kerangka kerja Laravel. Sistem tersebut dibangun mengikuti metode waterfall, yang mencakup tahapan perencanaan, pemodelan, konstruksi, dan pengiriman sistem perangkat lunak kepada pelanggan/pengguna, yang diakhiri dengan fase pemeliharaan untuk aplikasi tersebut. Temuan dari penelitian ini menunjukkan bahwa implementasi sistem informasi berbasis website untuk pencatatan penjualan pakan hewan secara signifikan memperlancar berbagai proses transaksi di Toko Budi Jaya.
Aplikasi Rental Mobil (Armo)
Authors: Putra Davito Rasendriya Rizqullah , Astutik Ika Ratna Indra
Published: August 2024

Pengembangan website ini telah menjadi sesuatu yang esensial dalam memenuhi kebutuhan seperti perjalanan dan pemenuhan dasar sehari-hari. Penerapan PHP sebagai bahasa pemrograman utama memungkinkan pengembangan yang fleksibel dan skalabel, serta mendukung integrasi dengan basis data untuk menyimpan informasi pelanggan, mobil yang tersedia, dan transaksi sewa. Salah satu inovasi yang ditambahkan dalam website ini adalah penggunaan countdown timer dengan JavaScript. Countdown timer digunakan untuk memberikan informasi waktu tersisa pada setiap pemesanan mobil, memberikan pengguna kesempatan untuk menyelesaikan proses pembayaran atau konfirmasi sebelum waktu habis dan dapat digunakan menjadi patokan agar pelanggan terhindar dari sanksi atau denda sesuai kebijakan rental mobil tersebut.
Analisis Konten pada Pemberitaan Mengenai Mobil Listrik di Channel Youtube CNBC Indonesia
Authors: Alzani Muhamad Rizki , Syarifudin Achmad , Trisiah Anita
Published: August 2024

Penelitian ini merumuskan masalah terkait bagaimanakah analisis pada konten pemberitaan mengenai mobil listrik di Channel Youtube CNBC Indonesia. Jenis Penelitian ini menggunakan metode analisa kualitatif dan pendekatan menggunakan metode analisa konten berupa teori analisis framing.  Subjek penelitian ini bersumber dari konten video yang ada di channel Youtube CNBC Indonesia. Channel Youtube CNBC Indonesia. Teknik pengumpulan data yang digunakan ialah observasi dan dokumentasi. Sedangkan teknik analisa data terdiri dari reduksi data, penyajian data, dan penarikan kesimpulan atau verifikasi. Hasil penelitian diperoleh analisis pada konten pemberitaan mengenai mobil listrik di Channel Youtube CNBC Indonesia yaitu pada penelitian ini dilakukan pada 5 video konten berita di Youtube CNBC Indonesia. 5 video konten berita tersebut dipilih berdasarkan jumlah viewers terbanyak yang terkait dengan mobil listrik. Secara keseluruhan, kelima video memberikan framing yang komprehensif tentang isu-isu terkait teknologi mobil terbang dan mobil listrik melalui empat fase elemen framing. Setiap video menunjukkan kompleksitas isu yang diangkat dan menawarkan pandangan yang seimbang mengenai potensi dan tantangan teknologi ini, serta langkah-langkah yang diperlukan untuk mencapai tujuan transportasi yang lebih efisien dan ramah lingkungan.
Optimization of the Weir as a Micro Hydro Power Plant in Bayang Nyalo Padang, West Sumatra
Authors: Yulianti Erni , Prasetyo Eko
Published: August 2024

The objective of this research is to guarantee that the building of PLTMH Bayang Nyalo achieves maximum energy output and utilizes possible renewable energy sources in a sustainable and efficient manner. This research is a study that aims to describe and analyze data using a quantitative technique. The quantitative research technique is used when study data is in numerical form. Quantitative descriptive research is a method used to examine obtained data by providing a detailed and accurate description of the data. This study aims to determine the optimal value for designing small-scale hydropower plants (PLTMH). In order to do research for this thesis, the author investigates the number of studies performed in the Bead Dam Nyalo Kec. Nagari Bayang North, South Coast Regency West Sumatra. The PLTMH project aims to harness the water flow from the subterranean river, which has a discharge rate of 14.67 liters per second. The power plant is designed to have a power capacity of 623.32 kW, using a high discharge waterfall with an effective height of 5 m. Based on the examination of technological elements, we have reached conclusions: The civil component of this PLTMH includes a gravity concrete dam that is prepared for operation, while the electrical components consist of a Cross flow Turbine. The development of mechanical transmission is ongoing.
Metallic nanomaterials – targeted drug delivery approaches for improved bioavailability, reduced side toxicity, and enhanced patient outcomes
Authors:   Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Croitoru George-Alexandru , Pîrvulescu Diana-Cristina ,   Faculty of Chemical Engineering and Biotechnology, National University of Science and Technology Politehnica Bucharest, Romania, Niculescu Adelina Gabriela ,   Faculty of Chemical Engineering and Biotechnology, National University of Science and Technology Politehnica Bucharest, Romania; Research Institute of the University of Bucharest – ICUB, University of Bucharest, Romania, Grumezescu Alexandru Mihai ,   Faculty of Chemical Engineering and Biotechnology, National University of Science and Technology Politehnica Bucharest, Romania; Research Institute of the University of Bucharest – ICUB, University of Bucharest, Romania, Antohi Alexandru Mihai ,   Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Nicolae Carmen-Larisa ,   Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Published: August 2024

This paper explores the integral role of metallic nanomaterials in drug delivery, specifically focusing on their unique characteristics and applications. Exhibiting unique size, shape, and surface features, metallic nanoparticles (MNPs) (e.g., gold, iron oxide, and silver NPs) present possibilities for improving medication efficacy while minimizing side effects. Their demonstrated success in improving drug solubility, bioavailability, and targeted release makes them promising carriers for treating a variety of diseases, including inflammation and cancer, which has one of the highest rates of mortality in the world. Furthermore, it is crucial to acknowledge some limitations of MNPs in drug delivery before successfully incorporating them into standard medical procedures. Thus, challenges such as potential toxicity, issues related to long-term safety, and the need for standardized production methods will also be addressed.
Eosinophilic fasciitis: unraveling the clinical tapestry of a rare case and review of literature
Authors:   Department of Internal Medicine, Colentina Clinical Hospital, Bucharest, Romania, Cherim Aifer , Bastian Alexandra Eugenia ,   Department of Pathology, Colentina Clinical Hospital, Bucharest, Romania, Popp Cristiana Gabriela ,   Department of Pathology, Colentina Clinical Hospital, Bucharest, Romania, Mihon Maia Ioana ,   Department of Rheumatology, Emergency County Clinical Hospital, Cluj, Romania, Efrem Ion Cristian ,   Department of Internal Medicine – Medical Semiology, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania; Department of Internal Medicine, Philanthropy Clinical Hospital, Craiova, Romania, Vreju Ananu Florentin ,   Department of Rheumatology, Emergency County Hospital, Craiova, Romania, Ionescu Răzvan Adrian ,   Department of Internal Medicine, Colentina Clinical Hospital, Bucharest, Romania
Published: August 2024

Eosinophilic fasciitis (EF) remains a diagnostic challenge due to its rarity and resemblance to scleroderma. This case report aims to provide a cohesive exploration of EF’s clinical nuances, emphasizing the importance of accurate diagnosis and effective management. A 52-year-old male developed bilateral forearm and calf hardening, along with erythema, pruritus, and pain four months prior to the presentation in our Clinic. The symptoms initially debuted bilaterally in the forearms and progressed to involve the calves, distal arms, and thighs. Clinical examination revealed symmetrical plaques on forearms and calves, featuring erythematous, hyper, and hypopigmented elements extending proximally, a positive “groove sign” and a moderate difficulty in knee joint flexion. Despite these findings, the patient was generally in good condition, without any other notable clinical signs. Initial laboratory findings showed slightly increased percentual eosinophil levels, elevated C-reactive protein (CRP), normal erythrocyte sedimentation rate (ESR), and negative antinuclear and scleroderma specific antibodies. Magnetic resonance imaging (MRI) demonstrated enhanced fascial signal and thickening while the fascia-muscle biopsy revealed marked edema and inflammatory lymphoplasmacytic infiltrate, consistent with the diagnosis of EF. The patient showed a favorable response to systemic corticosteroids. EF predominantly affects males aged 30 to 60 and is characterized by a sudden onset and unclear etiological factors. Differential diagnosis requires careful exclusion of scleroderma and other mimicking conditions. Diagnostic modalities such as skin-muscle biopsy and MRI reveal characteristic findings like inflammatory infiltrate and fascial thickening. Accurate diagnosis and differentiation from scleroderma are crucial, with early intervention involving glucocorticoids and immunosuppressive agents improving long-term outcomes.
ORCHID DIVERSITY (Orchidaceae) IN TWO URBAN SITES IN THE STATE OF VERACRUZ, MEXICO
Authors: Baltazar-Bernal Obdulia , Zavala-Ruiz Jesús , Hernández-García Arturo
Published: August 2024

Knowledge of urban orchids and their phorophytes is essential for conservation and education initiatives in these areas. The objective of this study was to assess the diversity of epiphytic orchids and identify their phorophytes at Postgraduate College Campus Córdoba (CPCC) and Paso Coyol Ecological Park (PEPC) in order to better understand the differences in their composition. The hypothesis was that the diversity of naturally established orchids would be higher in the less urbanized area, while the phorophytes would be mostly introduced trees. Orchids growing on phorophytes of the garden area (12 000 m²) of both sites were quantified from November 2019 to December 2021. The origin (endemic, native, or exotic) of the orchids and their phorophytes were determined. Simpson and Shannon-Weaver diversity indices were applied, and Whittaker curves were developed. A total of 13 419 orchid individuals were recorded, divided into 31 species, with 26 species reported in the CPCC and 17 in the PEPC. The Simpson and Shannon-Weaver indices showed that the diversity of epiphytic orchids was higher in the CPCC (1-D = 0.78) than in the PEPC (1-D = 0.41). In contrast, species dominance was lower in the CPCC (H = 2.6) than in the PEPC (H = 1.16). Whittaker curves showed that Catasetum integerrimum was the most abundant species in the CPPC and Platystele stenostachya in the PEPC. The CPCC had a greater level of diversity. Fifteen species of phorophytes were recorded in the CPCC and 10 in the PEPC, with a predominance of exotic species, while introduced species accounted for 70 % of the phorophytes found.
The Price to Book Value Still Influenced by The Main Factors on SDG's?
Authors: Nawawi Achmad , Disman  , Nugraha  , Waspada Ikaputera
Published: August 2024

Objectives: This study aimed to obtain empirical evidence and analyze the influence of Return on Assets (ROA), Loan to Deposit Ratio (LDR), and Debt to Equity Ratio (DER) on Price to Book Value (PBV) in state-owned banks listed on the Indonesia Stock Exchange from 2011 to 2021.
 
Theoretical Framework: The research is grounded in financial performance and valuation theories, emphasizing how internal financial ratios impact the market valuation of firms, particularly in the banking sector.
 
Method: This research design is quantitative. The data used in this research comes from financial reports registered on the IDX.
The data that has been collected is then analyzed descriptively.
 
Results and Discussion: The analysis revealed that ROA significantly affects PBV, indicating that higher profitability leads to higher market valuation. Conversely, LDR and DER do not significantly impact PBV, suggesting that liquidity and capital structure are not primary determinants of market valuation in the context of these banks. The simultaneous effect of ROA, LDR, and DER on PBV was also observed.
 
Research Implications: These findings suggest that investors and financial analysts should focus more on profitability metrics such as ROA when evaluating the market value of state-owned banks. The insignificance of LDR and DER implies that other factors may play a more crucial role in influencing PBV in this sector.
 
Originality/Value: This study provides updated empirical evidence on the determinants of PBV in the context of Indonesian state-owned banks, contributing to the existing literature on bank valuation and offering practical insights for investors and policymakers.
Telework in Administrative Management within the Framework of the SDG, in a Peruvian Public Institution
Authors: Chacchi Denisse Vanessa García , Sotelo Cristian Gumercindo Medina , Pacherres Miguel Ángel Atoche , Ladera- Castañeda Marysela , Pacherres Patricia Atoche , Pacherres Jorge Hernán Atoche
Published: August 2024

Objective: The objective of the research was to determine the influence of teleworking on administrative management in a Peruvian public institution. The same one that is associated with the Sustainable Development Goal (SDG) “Promote inclusive and sustainable economic growth, employment and decent work for all.”
 
Theoretical framework: Teleworking consists of tasks carried out without the physical presence of the worker, using computer and telecommunications means for control and supervision. This requires the employer to provide the necessary resources and manage technological dependence and ownership of the results.
 
Method: It was a basic study, with a non-experimental cross-sectional design. The sample was made up of 100 employees of a Peruvian public institution. The technique applied was the survey and a structured questionnaire was used for each variable.
 
Results and Discussion: A p value < 0.000 was found, which shows that there is a significant influence of teleworking on administrative management, showing an influence of 24%.
 
Research implications: Teleworking in the Peruvian administration improves implementation by reducing operating costs in the public sector, offering flexibility to collaborators, increasing productivity and allowing the hiring of talent without geographical limitations.
 
Originality/value: Teleworking in the administrative management of public institutions in Peru has been little researched, which makes this study an original contribution, since most previous research has focused on other contexts.
Human Talent Management in the Development of Work Skills in the Framework of The SDG in a Hospital in Peru
Authors: Pacherres Miguel Ángel Atoche , Ladera-Castañeda Marysela , Chacchi Denisse Vanessa García , Sotelo Cristian Gumercindo Medina , Pacherres Patricia Atoche , Pacherres Jorge Hernán Atoche
Published: August 2024

Objective: To determine the influence of human talent management on the development of labor competencies of the administrative staff of a hospital in Peru. This is associated with the Sustainable Development Goal (SDG) “Decent work and economic growth”.
 
Theoretical framework: Globalization and digitalization generate constant changes that force institutions to orient human talent management towards the development and specialization of workers' skills, through training and feedback.
 
Method: The basic study had a quantitative approach and a non-experimental cross-sectional design. The sample consisted of 86 employees, the technique used was the survey and a questionnaire was used for each variable. The ordinal logistic regression test was used for the inferential analysis, considering a significance level < 0.05.
 
Results and Discussion: The results of the model fit test showed a p-value of 0.000 < 0.05. Likewise, the Nagelkerke coefficient yielded a value of 0.239, determining that there is a 23.9% influence of human talent management on the development of labor competencies.
 
Implications of the research: Adequate human talent management will allow the development of the competencies of the hospital's administrative employees.
 
Originality/value: Human talent management in the development of labor skills in Peruvian hospitals has been little explored, which makes this study an original contribution, given that most research has focused on other contexts.
Responsive Knowledge Management Framework in the Philippine House of Representatives for Policy Development
Authors:   University of Perpetual Help Systems Dalta, Las Piñas, Philippines, G. Coronel Jaybee
Published: August 2024

This study formulated a Knowledge Management Framework for the Philippine House of Representatives Secretariat- the organizational arm of the House of Representatives (HRep) to improve the technical and administrative support services to the House Members. The researcher interviewed employees from the Committee Affairs Department to describe their required features of a technology-based system, practices, and initiatives for the implementation of a framework as a basis for the development of a KM system. The developed KM framework integrated the models of Alshamsi and Othman, 2021 and the Input-Process-Output (IPO) model Galais et. al (2021), illustrated the cyclical nature of knowledge creation, sharing, and utilization within the organization, and the researcher included an outcome as the framework should reflect the long term development goals of the HRep. The framework will be the basis of the HRep in assessing the current systems in the HRep, evaluating the proposed systems, and developing indicators for monitoring and evaluation in case a certain system is already implemented.
A shot of resilience: evaluating the potential of parametric drought insurance for non irrigated coﬀee crops in southern Minas Gerais
Authors:   , Schmidt Luís Alberto Campos
Published: August 2024

Coﬀee production in Brazil, particularly in the South/Southwest region of Minas Gerais, faces challenges due to increasing drought frequency and severity. This study investigates the feasibility of parametric drought insurance as a risk management tool for non-irrigated coﬀee growers in this region. We analyze historical coﬀee yield data and weather data to assess the eﬀectiveness of parametric drought insurance in reducing risk exposure. Diﬀerent payout structures are proposed, considering trigger levels, payout intervals, and the unique biennial bearing cycle of coﬀee trees. The performance of these contracts is evaluated under diﬀerent scenarios to account for premium loading and government subsidies. Results demonstrate the potential of parametric drought insurance to mitigate income volatility during dry years. The ﬁnancial safety net provided by the insurance can be particularly beneﬁcial for risk-averse coﬀee growers. Furthermore, our ﬁndings suggest that parametric insurance might require continued subsidies to achieve widespread adoption, especially considering risk-averse farmers who are more sensitive to basis risk. By estimating the relationship between drought indices and yields across diﬀerent yield distribution quantiles for various municipalities over time, this study provides a more robust understanding of how droughts aﬀect yields at diﬀerent points in the distribution. Subsequently, this study evaluates the eﬀectiveness of the proposed insurance product from the perspective of coﬀee farmers through eﬃciency analysis. First, we compare the ﬁnal wealth trajectories of farmers with and without insurance, considering downside risks measured by mean-semivariance. Second, we evaluate whether the insurance oﬀers an attractive risk-return trade-oﬀ for diﬀerent risk aversion proﬁles using Stochastic Eﬃciency with Respect to a Function (SERF). This study contributes to advancements in agricultural risk management strategies by oﬀering a comprehensive analysis of parametric drought insurance for tree crops, particularly coﬀee. It oﬀers valuable insights for policymakers and insurance providers seeking to enhance risk management strategies for coﬀee growers in Brazil. Keywords: Parametric drought insurance. Coﬀee production. Agricultural risk manage- ment. Basis risk. Panel Quantile Regression. Eﬃciency analysis.