bluuebunny/crossref_metadata_2025 huggingface dataset:
proceso de negociación en compañías de consumo masivo en Colombia en entornos VUCA, caso COVID-19*
Authors: Briñez Rincón Moisés Eduardo , Zuleta Muñoz Melissa
Published: January 2024

Las compañías de consumo masivo en Colombia deben llevar a cabo negociaciones de manera constante, sin embargo, el proceso de negociación no debe ser concebido como un estándar que se ejecuta incontables veces. Por el contrario, es fundamental tener en cuenta el contexto. En tal sentido, este artículo tiene como objetivo proponer una metodología de negociación efectiva, aplicable en entornos volátiles, inciertos, complejos y ambiguos (VUCA) en Colombia —caso COVID-19—. Con este fin, se consultaron en diversas fuentes bibliográficas las metodologías de negociación existentes y los efectos que ha causado la pandemia, para determinar un proceso de negociación óptimo, identificando los efectos que podrían tener impactos más relevantes sobre los resultados de la negociación. Así, se desarrolló un instrumento compuesto por 61 ítems, validado por tres expertos. Este se implementó en 37 unidades informantes, pertenecientes a la Cámara de la Industria de Alimentos y la Cámara de la Industria de Bebidas de la ANDI. Se obtuvo un coeficiente de 0,887, reflejando un nivel de confiabilidad aceptable. Al identificar efectos generados por la pandemia de COVID-19 en el proceso de negociación de las compañías de consumo masivo de Colombia, se encontraron tres tipos de impactos: efectos en la comunicación, efectos en la economía y efectos en las variables del consumidor. La media de los ítems de esta variable fue de 3,86 y la mediana fue 4, representando una tendencia de validación muy positiva. Dichos resultados permitieron diseñar una metodología que implementa técnicas de negociación efectivas en momentos de incertidumbre, identificando los impactos que tuvo el COVID-19 en la negociación de abastecimiento y ventas, así como la manera en que deben ajustarse y transformarse los procesos a diferentes situaciones
Epidemiology of unintentional injuries among 15–24-year-old vocational school youth from Peshawar Pakistan: A cross-sectional survey.
Authors: Masud Sarwat , Hyder Adnan A. , Khan Uzma Rahim , Khan Nadeem Ullah , Raheem Ahmed , Petrucka Pammla
Published: January 2024

Background:
The burden of unintentional injuries among youth (15-24 years) is high. There is paucity of data on unintentional injuries in youth working in Vocational Training Institutes.
Objective: To determine the incidence, characteristics, and risk factors of unintentional injuries among youth.
Methods:
Design: A retrospective cross-sectional survey was conducted among select vocational school youth in Peshawar, Pakistan between February 2022 to October 2022.
Participants: A total of 547 study participants participated in the survey, 356 were males while 191 were females. Data were collected on using the World Health Organization community survey guide for injuries and violence. Multilevel Negative Binomial Regression model was used to report incidence rate ratios of all unitentional injuries.
Results: A total of 503 injuries were reported by the youth, with road traffic injuries being the most common (n=197, 39%), followed by burns (n=89, 18%), falls (n=79, 16%) and poisonings (n=15, 3%), drownings (n=23, 7.1%). Occupational injuries reported during vocational training were (n=95, 18%). Males had a higher incidence rates of RTI 3.24[2.35-5.3], falls 1.30 [0.74-2.27], poisonings 2.14 [0.57-7.58] and drownings 2.46(0.84-7.21), while females had a higher incidence rate of burns 2.19 [1.785-3.46].
Lack of education 4.6 [1.12 -18.91] (p=0.034), smoking 1.25 [1.05 -2.69] (p=0.049), lack of fathers education 4.71 [2.12 -10.49] (p=<0.001), carrying a gun 6.59 [2.54 -17.11] (p=<0.001), crowded families 3.59 [3.11 -5.07] (p=<0.001), lower family income 2.04 [1.04 -4.02](p=0.039*), lack of helmet use 4.54 [2.12 -9.76] (p=<0.001) and lack of seat belt use 1.3 [1.14 -1.69] (p= <0.001) were significant risk factors for unintentional injuries in youth.
Conclusion Added value of the study:
This study is one of the first research studies conducted in vocational school youth in Pakistan. It provides the recent rate of unintentional injuries among the youth of Pakistan. High occupational injuries among vocational school youth were reported which needs further research.
Broadband 3μm MIR emission from Lead-free perovskite fluorine composite glass and CO2 monitoring in H2 applications
Authors: Zhang Yueming , Zhang Xiaosong , Zhang Zhaowei , Li Chao , Chen Minxing , Huang Shuwei , Gong Xiaokai , Xu Jianping , Li Lan
Published: January 2024

The conventional hydrogen production process is accompanied by the production of large amounts of carbon dioxide, which affects the application of hydrogen energy. Therefore, it is necessary to monitor the carbon dioxide content of hydrogen gas. Due to their excellent optical properties, all-inorganic perovskites can be made into photoluminescence sensors for monitoring gas concentrations. However, toxic lead halide perovskites are limited in photoelectric applications due to their instability and other drawbacks. Perovskites have rarely been studied for broadband luminescence in the mid-infrared range. Herein, this work reports on Dy3+/Er3+ co-doped Cs3Bi2-m-nErmDynBr9-ZBLAN (ZrF4-BaF2-LaF3-AlF3-NaF) perovskite fluorine composite glass, which can radiate a broadband mid-infrared luminescence located at 3 µm, covering the characteristic absorption peak of CO2 at 2.7 µm. A CO2 monitoring device is built based on this feature. The use of Bi3+ to replace Pb2+ to form Cs3Bi2Br9 reduces the toxicity of perovskites. The dense and inert nature of the glass is used to isolate the lead-free perovskite Cs3Bi2Br9 from the external environment, thereby improving stability. The addition of Cs3Bi2Br9 not only decreases the phonon density of states in the glass matrix but also changes the local field around the Er and Dy ions. The luminescence of rare earth ions in the mid-infrared is thus enhanced. Cs3Bi2-m-nErmDynBr9-ZBLAN perovskite fluorine composite glass is a promising candidate for future mid-infrared emitting materials due to its non-toxicity and broadband mid-infrared luminescence at 3 µm.
Identification and Validation of Novel Biomarkers for Alzheimer's Disease Based on Akt and Wnt Signaling Pathways
Authors: Wang Yahan , Li Bo-Wen , Xin Chao , Zhang Kai-Xin , Wu Hongyun , Cui Wen-Qiang , Xu Xiang-Qing , Zhang Ji-Wei , Zhi Hong-Wei
Published: January 2024

Background
Alzheimer's disease is a neurodegenerative disease that is difficult to reverse. Akt and Wnt play a role in complex cellular signaling, which is important for studying the onset of AD. This study aimed to screen key genes of the Akt and Wnt pathways as potential biomarkers for the early diagnosis and treatment of AD.
Methods
We searched for differentially expressed genes in the GEO database, constructed candidate gene protein-protein interaction (PPI) networks, and used least absolute shrinkage and selection operator (LASSO) regression analysis and the support vector machine-recursive feature elimination (SVM-RFE) algorithm to screen for key genes. Correlation and functional similarity analyses of key genes, immune infiltration analysis, ceRNA network construction, and drug prediction of key genes were performed. We further validated the expression of key genes in streptozotocin (STZ)-treated AD mice using quantitative reverse transcription (RT-q) PCR.
Results
Bioinformatic analysis identified five key genes in AD, including PRKACA, CDH3, ATP6V0C, DLL1, and CELSR2. Step-down tests, immunohistochemistry, and silver plate staining confirmed the success of STZ-induced AD in mice. PCR showed that the relative expression of DLL1 mNRA in the AD group was higher than that in the control group, whereas the relative expression of ATP6V0C and PRKACA mRNA in the AD group was lower than the control group, which was consistent with the results of the bioinformatic analysis.
Conclusions
This study provides a basis for a more comprehensive understanding of the underlying mechanisms of AD. Furthermore, DLL1, ATP6V0C, and PRKACA may be potential intervention targets for AD.
Best among the key molecular diagnostic markers of bacterial vaginosis
Authors: Deng Tongyang , Song Xiangquan , Liao Qiumei , Zheng Ying , Sun Hong , Zhang Lianzhen , Chen XueJia
Published: January 2024

To assess bacterial vaginosis (BV)-related primary molecular diagnostic markers of Lactobacillus crispatus, Gardnerella vaginalis, Fannyhessea vaginae, bacterial vaginosis-associated bacteria 2 (BVAB-2), Megasphaera-1 and Megasphaera-2 and to discover molecular diagnostic indicators of BV with the most economic value for the efficient diagnosis of BV.All vaginal secretion specimens, including 122 BV-positive cases and 130 BV-negative controls were collected. First, quantitative polymerase chain reaction (PCR) was used to determine the levels of above the six bacteria. Then, the detection rates, sensitivity, specificity, diagnostic threshold, and receiver operating characteristic (ROC) curve were compared.Megasphaera-1 and Megasphaera-2 were detected in the BV-positive group, with a low detection rate of 35.25% and 19.67% respectively. The sensitivity and specificity of the above four bacteria were 95.90%/72.31%, 82.79%/92.48%, 72.13%/95.38%, and 56.56%/94.62% respectively, using the cut-off value for the diagnosis of BV. When combinations of L. crispatus with G. vaginalis, F. vaginae, and BVAB-2 were performed respectively, their sensitivity and specificity were 99.29%/97.79%, 98.86%/98.72%, and 98.22%/98.51% in sequence.It is difficult to diagnose BV using only one species, however, combinations of L. crispatus with G. vaginalis or F. vaginae showed a better diagnostic effect, particularly with the combination of L. crispatus and G. vaginalis.
New 1,3,4-Triaza-3H-indene Derivatives in Theoretical, Experimental and biological Studies
Authors: Ouzidan Younes , Hjouji Mohammed-Yassin , Hafez Baraa , Chraibi Marwa , Ousmane Dounia , Benbrahim Kawtar Fikri , Amanarne Rachida , Abbadi Khalil EL , Latif Mouad , el Hicham , elhenawy Ahmed , Naglah Ahmed , Almehizia Adulrahman A. , Rodi Youssef Kandri
Published: January 2024

6-Bromo-2-phenyl-1,3,4-triazaindan under solid-liquid catalysis-transfer-phase(CTP) environment, pyridine interacts with a number of halogenated derivatives to produce the anticipated regioisomer molecules 2a and 2b. Besides, the reaction of compound (1) with bis(2-chloroethyl) amine results in the corresponding isoxazolidin-2-one derivatives (3a) and (3b) at a satisfactory yield. The synthesized compounds are confirmed by X-ray diffraction, spectral techniques (1H NMR, 13C NMR). Then, 1,3,4-Triaza-3H-indene derivatives were analyzed in silico based on molecular structure by molecular docking analysis to determine which one could be used for in vitro antibacterial activity testing. The compounds with the highest binding efficiency in the docking experiment were chosen to be evaluated against both Gram-positive and Gram-negative bacteria. These compounds showed higher efficacy against Gram-positive bacteria than Gram-negative bacteria, which are much more resistant to them.
Examining lifestyle factors as potential moderators in the link between childhood adversity and comorbid psychological distress and obesity in early adulthood
Authors: Woofenden Tom , Fairchild Graeme , Lancaster Tom
Published: January 2024

Background: Whilst childhood adversities are risk factors for mental, physical, and comorbid health problems in childhood and middle-to-late adulthood, there is less evidence for these associations in early adulthood. It is also unclear if lifestyle factors modify the risk of these health outcomes following childhood adversities. This study aims to examine childhood adversities as risk factors for psychological distress, obesity, and their comorbidity, and further quantify the moderating impact of lifestyle factors. This could provide insight into potential protective influences against the detrimental health consequences of childhood adversities, particularly mental-physical comorbidity.
Methods: Analyses were conducted on data from the 1970 British Cohort Study (n=16,407). The cumulative impact of parent- and self-reported adversities (range 0-33) were consolidated across childhood (0-16 years) and examined as a predictor of psychological distress (Malaise Inventory ≥ 8), obesity (BMI ≥ 30 kg/m2) and their comorbidity in early adulthood (30 years) using multinomial logistic regression. Self-reported lifestyle factors in adolescence (16 years), including physical activity, diet, sleep duration, smoking, and alcohol consumption were assessed as moderators of the association between childhood adversities and the specified outcome categories.
Results: A one-item increase in reported childhood adversities elevated the risk of psychological distress (OR [95% CI]; 1.11 [1.09, 1.13]), obesity (OR [95% CI]; 1.05 [1.03, 1.06]) and mental-physical comorbidity (OR [95% CI]; 1.16 [1.12, 1.20]). Compared to comorbidity, childhood adversity was a weaker risk factor for psychological distress (OR [95% CI]; 0.96 [0.92, 0.99]) or obesity alone (OR [95% CI]; 0.90 [0.87, 0.94]). None of the examined lifestyle factors were significant moderators of the association between childhood adversities and the outcome categories.
Conclusions: Consistent with evidence from middle- to late-adulthood, childhood adversities showed a stronger association with comorbidity in early adulthood than mental or physical health problems alone. There was no evidence that lifestyle factors influenced the association between childhood adversities and comorbidity or individual health problems. Our findings highlight the importance of considering comorbidities when investigating the negative health consequences of childhood adversities, and therefore, the continuing need to identify factors which mitigate the increased risk of comorbidity.
Improving postharvest quality and vase life of cut rose flowers by pre-harvest foliar co-applications of γ-Aminobutyric Acid and calcium chloride through antioxidant contents
Authors: Ehsanimehr Narges , Hosseinifarahi Mehdi , Abdipour Moslem , Eshghi Saeid , Jamali Babak
Published: January 2024

Rose flowers (Rosa hybrida L.) are highly perishable and have a limited postharvest life. This study evaluated the effects of preharvest foliar applications of γ-aminobutyric acid (GABA) and calcium chloride (CaCl2), individually and in combination, on antioxidant responses and vase life of cut Jumilia rose flowers. Treatments included foliar sprays of GABA at 0, 20, 40, and 60 mM and CaCl2 at 0, 0.75%, and 1.5%, applied in a factorial design within a completely randomized setup before harvest. Results showed GABA and CaCl2 interaction (especially, 60 mM GABA and 1.5% CaCl2) significantly increased enzymatic antioxidants including superoxide dismutase, catalase, and peroxidase, as well as non-enzymatic antioxidants such as flavonoids, carotenoids, phenolics, and antioxidant activity in petals compared to control. SOD activity in roses, treated with CaCl2 (1.5%) and GABA (60 mM), peaked at 7.86 units. mg-1 protein min-1, showing a nearly 2.93-fold increase over the control (2.68 units. mg-1 protein min-1). A parallel trend was observed for CAT activity. These treatments also reduced petal malondialdehyde content and polyphenol oxidase activity. Protein content and vase life increased in all treatments. Plants treated with a combination of GABA (20 mM) and CaCl2 (0.75%), GABA (60 mM) and CaCl2 (1.5%), or GABA (40 mM) individually exhibited the longest vase life duration. These findings suggest the preharvest application of GABA and CaCl2 can enhance antioxidant capacity and vase life of cut roses and also delay senescence.
DTMA: Visual Object Inspection and Mechanism for Digital Twin with Robotic Arm
Authors: Venkataraman Hrishikesh , Nidamanuri Jaswanth , Dittakavi Aditya V , Y Raja vara prasad , Trestian Ramona , H Nguyen
Published: January 2024

Over the recent years, the manufacturing sector has been rapidly changing the operational mechanism using advanced technologies such as Artificial Intelli- gence, Computer Vision, etc. The availability of various categories of sensors like IoT, IMU, obstacle detecting sensors, actuators embedded in the system helps to visually monitor the manufacturing process. However, there are many challenges that are yet to be addressed in Cyber-Physical Systems (CPS) and industry
4.0. This includes reliability, precision, adaptability and multi-sensor informa- tion fusion and analysis. Hence, this work proposes an advanced and integrated framework Digital Twin Manipulator Arm (DTMA) that establishes the primary base for industrial level analysis of Digital Twins, including the required concepts of anomaly detection. The main objective of the proposed DTMA framework is three-fold. The first objective is to design a digital twin of robotic arm. The second is to design the visual inspection module for object inspection in man- ufacturing process. The third objective is to integrate both the modules with automated correction using robotic arm in to the entire process. The applica- tion of DTMA framework is gauged from two different use-cases discussing the heuristic based block level functioning of the proposed framework. The proposed framework will enable the development of mechanisms for key advantages such as predictive maintenance, reduced operation cost, visual inspection with higher processing rates and improved productivity.
Clinical and microbiological characteristics of persistent Staphylococcus aureus bacteremia and risk factors for mortality: CD4 + T cells play an important role
Authors: Yang Eunmi , Cho Yeong Geon , Kim Eunsil , Chang Euijin , Bae Seongman , Jung Jiwon , Kim Min Jae , Chong Yong Pil , Kim Sung-Han , Choi Sang-Ho , Lee Sang-Oh , Chung Yun Shin , Kim Yang Soo
Published: January 2024

Objectives
This study evaluated the risk factors for mortality and the T cell immune response in patients with persistent Staphylococcus aureus bacteremia (SAB).
Methods
We studied a prospective cohort of adults with SAB at a tertiary-care hospital in South Korea from 2008 to 2020. We compared the clinical and microbiological characteristics of patients with persistent bacteremia (PB). The concentrations of cytokines and the proportions of IFN-γ secreting CD4+ T cells were measured serially during the bacteremia period.
Results
Of the 1,760 patients, 242 had PB, and 49 PB patients died within 30 days. In the multivariate analysis, the APACHE II score, liver cirrhosis, and female sex were independently associated with 30-day mortality. The level of IL-10 was significantly increased in the plasma of patients with a high Pitt bacteremia score and those who died within 12 weeks from the index day. The proportion of IFN-γ-secreting CD4+ T cells were the highest just before the positive-to-negative conversion of blood cultures in patients with a low Pitt bacteremia score and those who survived for 12 weeks.
Conclusions
The level of IL-10 is correlated with clinical outcomes in PB patients. IFN-γ secreting CD4+ T cells might play a pivotal role in SAB PB.
Impact of level of Enset (Ensete ventricosum, Musaceae) Production on Food and Nutrition Security: Empirical Evidences from Wolaita and Kembata Tambaro Zones of Southern Ethiopia
Authors: Bassa Zekarias , Ketema Mengistu , Kuma Berhanu , Mehary Abule
Published: January 2024

Enset is the only crop that can define food and nutrition security literally. Enset crop is closely related to food availability, access, use, stability, and nutrient balancing of densely populated communities in Wolaita and Kembata Tembaro zones. The climate smart, adaptive, productive, economical, and socially important Enset crop is the optimal way for ensuring food and nutrition security of communities. Hence, this study aims to estimate the causal effect of the level of Enset Production on farmers’ food and nutritional security in Southern Ethiopia. The survey applied structured and semi structured questionnaires for the collection of cross-sectional data from 374 sampled households in Wolaita and Kembata Tambaro Zones. Generalized Propensity Score (GPS) with multilevel treatment option was applied to deal with the impact evaluation of Production on food and nutrition security. Food and nutrition status of farming communities defined by calorie intake of households. The proxy measure of the level of Enset production was the number of Enset harvested across households in the last twelve months. The GPS method applied followed three estimation procedures such as modelling the conditional distribution of the treatment given the covariates, estimating the conditional expectation of the outcome given the treatment and GPS, and defining the dose response function. The results show that the small holder farmers that actively involved in harvesting Enset for food are significantly associated with increased level of daily energy intake. The implication of the study revealed that through the promotion level of Enset production, it is possible to have increased and balanced the energy intake of households in Southern Ethiopia. The empirical evidences illustrate that higher level of Enset harvesting is an optimal way for sustainable and better level of food and nutritious security for farming communities in southern Ethiopia.
Mechanism of AZDEGDN accelerating the decomposition of nitrocellulose: Insights from reactive molecular simulations
Authors: Zhang Ting , Qin Weihua , Meng Weifeng , Guo Zhuiyue , Cao Weiguo , Lan Yanhua
Published: January 2024

To get better insight into the effect of plasticizer 1,5-diazido-3-oxopentane (AZDEGDN) on the decomposition of nitrocellulose (NC) binders, thermogravimetric (TG) and Reactive forcefield (ReaxFF) simulation were conducted. The decomposition process of NC and NC/AZDEGDN was simulated at different temperatures (1000-3500 K), as well as the reaction path, main products, and decomposition mechanism. The main decomposition products of NC/AZDEGDN by ReaxFF-MD were N2, H2, NH3, H2O, CO2, and NO2, and the main generation pathways were summarized and verified by radial distribution function. The addition of AZDEGDN decreased the activation energy of NC, and accelerated the decomposition of NC. Some molecules and fragments decomposed from AZDEGDN reacted with the intermediates of NC molecular chains, and promoted the decomposition of NC. Meanwhile, NO2 decomposed from NC acted on AZDEGDN molecules to accelerate the decomposition of AZDEGDN. This study provides atomic insights into the decomposition process of NC/AZDEGDN, which may be helpful for further research on the reaction mechanism of energetic fuels.
Automatic placement of cameras in a particle accelerator using a 3D engine and computational optimization
Authors: Cruz N.C. , Rouret M. , Ortigosa E.M. , Ros E. , Garrido J.A.
Published: January 2024

Particle accelerators have high-radiation parts requiring remote maintenance tasks, which involve using cameras generally placed by human experts. This work addresses camera placement through black-box global optimization. This approach allows opting for automated solutions and relieving experts of that responsibility. The formulation of the objective function hides the environment-specific placement constraints and shows domain ones only. The proposed methodology allows the use of regular meta-heuristics for standard black-box box-constrained problems, as it is only necessary to honor the bounds of variables. Accordingly, the optimization algorithm used is the genetic algorithm provided by the Global Optimization Toolbox of MATLAB. The objective function computation relies on the simulation capabilities of the widespread Unity game engine. It brings us an integrated framework for defining the target process to consider and for checking the different proposals visually. Based on this framework, this work reconstructs the virtual reality simulation of a maintenance task in a particle accelerator. The results obtained show that the camera positioning achieved by the proposal for four cameras and one target process outperforms the arrangement defined by a human expert.
Effect of Acupuncture and Moxibustion, Cupping, and Medicated Thread Moxibustion on Sports Injuries
Authors: Shijun Xu , Cong Zeng , Ningmao Jiang , Qixing Liang
Published: January 2024

Objective: We explored the clinical effect of acupuncture and moxibustion therapy, cupping therapy, and Zhuang medicine thread moxibustion therapy on sports pains and injuries to explain this comprehensive therapy’s treatment mechanism from the perspective of traditional Chinese medicine and Zhuang medicine on the mechanism of Qi, blood, and body fluid.
Method: From 65 athletes who experienced sports pains and injuries during track and field and ethnic sports training for university sports events, we selected 32 patients as an observation group for comprehensive treatment with traditional Chinese medicine and Zhuang medicine. The treatment effect was compared with that of the 33-patient control group who received conventional therapy.
Result: The visual analogue scale was used to evaluate pain level, diagnose pain and injury severity, and evaluate efficacy. Comprehensive therapy had excellent efficacy for mild patients, and moderate-to-low intensity training could be performed during recovery. The observation group’s efficacy in delayed onset muscle soreness, mild injury, and severe injury was significantly better than that of the control group (P ≤ 0.05).
Conclusion: Acupuncture and moxibustion and cupping therapy combined with Zhuang medicine thread moxibustion therapy formed an integrated effect of treatment, cleared the veins, eliminated obstacles, unblocked meridians, relieved pain, promoted normal operation of Qi, blood, and body fluid, and restored vitality. Comprehensive therapy has the characteristics of simplicity, controllability, and effectiveness. Compared with conventional treatment, comprehensive therapy more effectively alleviated exercise-induced pain, especially with significant analgesic and rehabilitation effects on exercise-induced injuries. The consistency between the therapeutic effects of comprehensive and conventional therapies explains the unity of traditional Chinese medicine and modern medical principles. The combination of traditional Chinese and Western medicine can effectively treat sports injuries by leveraging their respective advantages, and this is also an effective path for traditional Chinese medicine’s sustainable development.
Correlation of PIK3R1 overexpression with CD73+ FOXP3+ regulatory T cell infiltration and its role in tumor progression and prognosis prediction in gastric cancer
Authors: CHAN HUANG , Yang Xinhua , Zou Bu , Yang Jiaojiao , He Huichan , Li Ting , Ye Zulu , Zhou Dalei , He Caiyun
Published: January 2024

Background
Biomarkers are crucially required to predict the prognosis of patients with gastric cancer (GC) and especially to identify those who may have intrinsic antitumor immune responses to immunotherapeutic strategies.
Methods
The publicly available databases, our cohort and the vitro experiments were used to identify the biological behavior mediated by PIK3R1 overexpression in GC. We evaluated the relationships between PIK3R1 expression levels and immune cell infiltration by immunohistochemistry, mRNA-seq data and single-cell sequencing data. Furthermore, both The Cancer Genome Atlas (TCGA) stomach adenocarcinoma data and cell lines were utilized to detect the function and mechanism of PIK3R1 in GC. Finally, the prognostic value of PIK3R1 was evaluated using an integrated nomogram.
Results
PIK3R1 expression levels were reduced in many human cancers, while they significantly increased in GC. High PIK3R1 expression levels were associated with disease progression and poor overall survival (OS). In vitro experiments, up-regulated PIK3R1 expression promoted the proliferation, invasion, and metastasis of GC cells. Further, PIK3R1 expression was closely correlated with regulatory T cell infiltration and its related biomarkers (such as FOXP3 and CD73). PIK3R1 overexpression was positively correlated with activated TGF-β/SMAD signaling in the TCGA cohort and the GC cell lines. Analysis of single-cell sequencing data demonstrated that PIK3R1 had an increasing trend during the transformation of benign cells into malignant cells and had a synchronous expression pattern with CD73 and several immunosuppressive molecules (such as FOXP3, LAG3, PDL1, GZMB, and GZMK) that play a role in T cell development. An easy-to use nomogram based on PIK3R1 and CD73 expression levels and several clinicopathological factors outperformed TNM staging at prognosis.
Conclusions
These findings inferred that PIK3R1 acts as a prognostic factor to predict the OS of patients with GC and implied the importance of developing novel immunotherapeutic strategies.
Enhancement of ON-Current in Modified TMG Vertical TFET with Split Pockets
Authors: Sivani K. , Harish B. , Kumar Ch. Pavan
Published: January 2024

This paper emphasizes the configuration of an N+ Si pocket overlay in a Vertical Tunnel Field Effect Transistor (VTFET), incorporating a gate-stacking process. In this design, the source pocket is divided into two segments with differing doping concentrations, specifically low and high concentrations. In Tunnel Field Effect Transistors (TFETs), the source pocket plays a vital role in augmenting the ON-state (ION) current. The vertical structure is implemented to alleviate scaling constraints and improve the device's scalability. To address ambipolarity, the gate electrode is divided into three segments with optimal work-functions of 4.15 eV, 4.30 eV, and 4.15 eV for the Auxiliary gate, Control gate, and Tunneling gate, respectively. The sub-threshold slope of short-channel Tunnel Field Effect Transistors (TFETs) will experience enhancement through a gate-stacking procedure employing high-k gate oxides, such as HfO2, in combination with SiO2 in the stack. Additionally, the pocket overlay positioned in the center of the source-channel region, utilizing low band gap group III-V materials, contributes to further improvements in the current ratio (ION / IOFF) and sub-threshold slope. In the presented device, the measured ION current and IOFF current are 8.14 x 10-3 A/μm and 5.37 x 10-11 A/μm, respectively. The threshold voltage is reduced to 0.2V. These achieved parameters establish the N+ Si pocket-doped Triple Metal Gate (TMG) VTFET as well-suited for applications demanding low power consumption.
Poly-ADP-ribosylation of KDM4D induces transcription in the hippocampus and amygdala
Authors: Savchenko Valentina L.
Published: January 2024

Poly-(ADP-ribose) polymerases (PARPs) play a significant role in DNA repair of single or double strand breaks and regulate transcription. PARPs also catalyze the Poly-(ADP)-ribosylation (PARylation) of proteins that are involved in the DNA repair and transcriptase machinery. PARP1 induces Poly-(ADP)-ribosylation of the enzyme lysine (K)–specific demethylase 4D (KDM4D) to modify the histone3 for triggering the transcription. The demethylation of H3K9me2 with KDM4D leads to an expression of transcription factors that are involved in the DNA repair. Thus, in addition to the significance of protein PARylation by PARP1 involved in the damaged DNA repair, the PARylation of KDM4D triggers the transcription in the hippocampus and amygdala.
Homologies between Chloroplast, plasma membrane, plastid, chloroplast envelope, putative [Theobroma cacao] and PEG10 protein [Homo sapiens]: a starting point for to deliver drugs to cells?
Authors: Andrade Luís Jesuino de Oliveira , de Oliveira Gabriela Correia Matos , de Oliveira Luisa Correia Matos , de Oliveira Luís Matos
Published: January 2024

Objective
The purpose of this study is to explore the possible homology between the AA sequences of Chloroplast, plasma membrane, plastid, chloroplast envelope, putative [Theobroma cacao] and PEG10 protein [Homo sapiens].
Materials and methods
Were performed the comparison with the VectorBuilder online, between the AA sequence of the GenBank: EOX96570 - Chloroplast, plasma membrane, plastid, chloroplast envelope, putative [Theobroma cacao] and GenBank: AAH50659.1 - PEG10 protein [Homo sapiens], using databanks of proteins from the National Center for Biotechnology Information (NCBI). The predicted structure of the GenBank: EOX96570 was used to design molecule that could target other proteins. The molecule was designed using a combination of EOX96570 with tyrosine kinase inhibitor (2X9F - ephB4 kinase domain inhibitor complex), accessed in the RCSB PDB database, by molecular docking and molecular dynamics simulations by SwissDock.
Results
The homology between the Chloroplast, plasma membrane, plastid, chloroplast envelope, putative [Theobroma cacao] and PEG10 protein [Homo sapiens], presented an identity of 51.72% (45/87) and a similarity of 51.72% ( 45/87). A molecule was designed using a combination of EOX96570 with a tyrosine kinase inhibitor (2X9F - EphB4 kinase domain inhibitor complex) through molecular docking and molecular dynamics simulations. The EOX96570 and the tyrosine kinase inhibitor were docked into the active site of the EphB4 kinase domain, taking into consideration their binding affinities and structural compatibility.
Conclusion
Bioinformatics data, suggest a possible link between Chloroplast, plasma membrane, plastid, chloroplast envelope, putative [Theobroma cacao] and PEG10 protein [Homo sapiens], and studies on the fruit of the cocoa tree are important to the safe, effective development of pharmaceutical products for the deliver drugs to cells.
Productivity and profitability of Wheat cropping system in southeastern Ethiopia
Authors: Dinsa Girma F. , Bogale Mengistu
Published: January 2024

As demand for food is rising, yield is expected to double to feed the 9 billion people in 2050. However, climate change is posing a pressing threat to sustainable food production for the increasing population. Wheat is a strategic crop for food security, and increasing its productivity is vital to ensuring food sufficiency. The dominant cropping system in the southeast Ethiopian highlands is wheat monocropping, which is constrained by the prevalence of yield-reducing factors such as diseases, pests and weeds. We evaluated combinations of crop management options to determine system productivity and profitability for sustainable wheat production. The production factors included in the treatment combinations were tillage type, crop rotation, and weed management options; these factors were applied during alternating (2007, 2009 and 2011) seasons, followed by the main crop (wheat) in the next season (2008, 2010 and 2012). Analysis of variance was performed for yield, weed population and economic parameters and revealed the significant effects of the management factors on wheat yield, weed population density and system profitability. A greater yield was obtained from fallow-retention followed by dry tillage and faba bean rotation. The weed population density was lower in the faba bean and rape seed rotations. All the broad leaf weed species were less than 25%, except for the Galium species, and all the grassy weeds were less than 30%, except for Cyprus species, in both the faba bean and rape seed rotation systems. In addition, Bromus pectinatus and Avena fatua were effectively controlled by rape seed and faba bean rotation, respectively, in the bread wheat production system. Rape seed rotation was the most profitable weed management option for bread wheat production, with a net benefit of 44,559 Ethiopian Birr (ETB)/ha and a net marginal return of 790 ETB/ha, which ensures that farmers receive an additional return of 6.90 ETB from each 1 ETB invested in the rape seed-wheat production system.
Place-based reading
Authors: Eggersen Dorte
Published: January 2024

This article presents a theoretically based model for place-based reading as a specific method for teaching literature outside the classroom. The model is designed for lower secondary school students (ages 13–16). With its four didactic stages, place-based reading is supposed to prompt and scaffold the students’ exploratory, bidirectional text–place attention. The place-based reading model’s theoretical foundations are presented by merging three broad academic fields: philosophies of place, literary topographies, and education outside the classroom (Danish: udeskole). The article is intended to contribute to a discussion of education that addresses how exploratory literature teaching outside the classroom could reveal to students that literature and the world surrounding them are related by concretizing the time element.
Open Label, Single Centre Study of Babao Relief Capsule as an Adjuvant to HAART in Antiretroviral Naive HIV Patients
Authors: Gen Lawson F. Simapuka Brig
Published: January 2024

HIV continues to be a major global public health issue, having claimed 36.3 million [27.2–47.8 million] lives so far (WHO, 2021). Sub-Sahara Africa remains the far worst affected region, with 20.6 million [16.8 million– 24.4 million] people living with HIV at the end of 2010, compared to 24.4 (22.5-27.3 million) in 2020. Complementary and alternative therapy (CAM) has been used to treat HIV patients by clinicians in conventional health services in combination with highly active antiretroviral therapy (HAART). To determine efficacy of Babao relief capsule when used as an adjuvant to standard HAART in antiretroviral naïve HIV patients. The product is a biological Chinese medicinal preparation, made of herbs. Ingredients include ginseng, beer antler, musk, bezoar, fleeceflower, Chinese angelica, lyceum, pericarpium citri reticulatae, safflower and ophiopogn japonicus. Open Label Phase 1 bridging Clinical trial to study the efficacy of Babao relief capsule when used in combination standard HAART in antiretroviral naïve HIV patients. A total of one hundred and ninety-six (196) adult patients attending the HIV clinic were randomly selected. The interventional group was on Babao relief capsule and HAART while the control group was on HAART only. The study shows general efficacy of the standard HAART drugs. However, the interventional arm showed a significant increase in the CD4 cell count, showing that BRC had booster effects in the efficacy of HAART. Keywords: HIV, Complementary and alternative therapy, Babao relief capsule, standard highly active antiretroviral therapy.
Analysis of Health System for Health Security: Case of Burundi
Authors: Jean Marie Ntampera , Luximon-Ramma Amitabye , Jacques Nshimirimana
Published: January 2024

Health system contributing to health security constituting an approach that harmoniously brings together efforts to strengthen the resources and capacities necessary for the implementation of the International Health Regulations, the components of health systems and those of other sectors for effective management of health emergencies, while maintaining the continuity of essential health services. The countries that have a weak health system face many challenges related to health security. A descriptive study was used during this study to identify if Burundi health system is contributing to the health security. 5health zones have been selected and 350 individuals questioned if they have received health education related to diseases with epidemic potential and if they have suffered from them. A questionnaire which includes the diseases with epidemic potential was distributed to 350 respondents between 20 to 55 years old. The majority (58%) of the respondents were female compared to 42% male. Most (93.0 %) respondents have received health education related to prevention of diseases with epidemic potential. The result shows significant differences in location, gender, marital status, occupation, and several outbreaks (P<0.001). The future research should focus on the re-organization of health systems to respond effectively to different heath threats, especially these can spread locally and globally. Identification of all these issues that can spread to neighbors, and which can cause high morbidity and mortality. of the country, the gaps, and priorities and to know where to convey the efforts for universal health coverage. Keywords: Burundi, Epidemic potential, Health system, health security, prevention.
Differentials in Male Circumcision Prevalence, HIV/AIDS Knowledge and Behavioral Prevention Practices Among Men in Nigeria
Authors: Obasi Odii Ikenna , Chipalo Edson
Published: January 2024

Compelling evidence regarding the HIV/AIDS reduction potentials of male circumcision abounds in sub-Saharan Africa, but men aged 15 to 59 years in Nigeria are mostly circumcised already. Yet, Nigeria continues to experience tens of thousands of deaths due to HIV/AIDS yearly, accounting for one of the highest HIV burdens worldwide. Differentials that may account for new HIV infections and high HIV prevalence rates need to be investigated. The purpose of this study was to examine the prevalence of male circumcision and determine the association between HIV/AIDS/STIs knowledge, contraception methods, and HIV prevention behavioral practices amongst men in Nigeria. This study utilized the 2018 Nigeria Demographic and Health Survey (n= 13,311). Chi-square tests were used to determine the prevalence of male circumcision. Two binary logistic regression models were performed to predict the relationship between independent and dependent variables. The prevalence of male circumcision was higher among men with knowledge of HIV/AIDS (98%) and other STIs (74%), used condoms (70.7%), and only 2.5% of men who sought advice/treatment were circumcised. Further evidence suggested that knowledge of HIV/AIDS was associated with higher odds of consistent condom use (AOR = 2.37; 95% CI =1.12 – 5.02), and knowledge of other STIs was significantly associated with higher odds of seeking advice/treatment for the last STIs (AOR= 3.06; 95% CI = 1.88 – 4.99). This suggests that comprehensive education regarding HIV/AIDS and STIs if prioritized may serve as both a protective and preventive mechanism to achieve HIV epidemic control among men in Nigeria. Keywords: Circumcised men, HIV/AIDS, HIV/AIDS knowledge, Sexually Transmitted Infections, Sexual behaviors, Nigeria.
How the Learning Disabilities Cause Psychosocial Problems among children in South Sudan: A Case of Jamjang Refugee Camps
Authors: Ngor Achiek Abraham , Selugo James
Published: January 2024

The study on the learning disabilities and associated psychosocial problems among children in South Sudan started in 2022 to 2024. The deepening loneliness and vulnerability of the children with the learning disabilities that influence the psychosocial problems among children resulted from the conflict in Sudan, which scattered families, social fabric, community structures, and pushed the families to seek international protection. The families have limited access to livelihood and highly dependent on relief services that exacerbate the situation for nurturing children. The study aimed at ascertaining the presence of the learning disabilities, associated psychosocial problems and the ways to mitigate and address a growing phenomenon among refugee children in Jamjang camps. The study employed qualitative, quantitative, and ethnographical/anthropological method to explore the growing phenomenon. The tools used in the design includes questionnaires, interviews, and observations. The study ascertained the presence of the learning disabilities among children which consists of dyslexia, dysgraphia, dyscalculia, attention deficit hyperactivity disorder, auditory processing disorder, visual and perceptual disorder. These conditions were manifested in deficiency to write, spell, comprehend, articulate written point, grammatical errors, arithmetic calculation, and inattention. The study confirmed how the learning disabilities cause the psychosocial problems which includes low self-esteem, lack of confidence, anxiety, depression, posttraumatic stress disorder, bully, stigma, and neglect. The finding confirmed the phenomenon can be addressed through mental health support, multisensory approaches, and Skinner’s Operant conditioning theory; Cognitive Behavioral theory of Bandura are crucial in reducing the adverse effects of the phenomenon. Keywords: Anxiety, Dyslexia, Depression, Dysgraphia, Learning Disabilities, Psychosocial.
Does Socio-Economics Factor Influence Beef Cattle Farmers' Ability to Adapt to Climate Change?
Authors: Putri Salwa Noor , Hartono Budi , Putritamara Jaisy Aghniarahim , Satria Awang Tri , Purwanti Tina Sri
Published: January 2024

The livestock industry is still struggling with the effects of climate change. All commodities, including beef cattle, are subject to the negative effects of climate change. One such effect is heat stress, which can result in losses in the form of reduced reproduction and productivity as well as welfare losses. The negative effects of climate change must be reduced through prevention, which includes adaptation. Beef cattle farmers make several different modifications. Socioeconomic considerations are one of the many types of factors that can contribute to this modification. This research was conducted in Probolinggo, Sumenep, and Tuban districts because these three areas have the largest beef cattle population in East Java. We interviewed 206 farmers using a questionnaire. The acquired data were examined using quantitative descriptive analysis and STATA 17 software with a multivariate probit model. This study discovered that beef cattle farmers used four adaptation strategies to deal with climate change, such as changing forage types to provide more nutrition; having routine immunization; working with veterinarians to improve biosecurity, vaccination, and animal health; and promoting artificial insemination using high-quality semen. Furthermore, socioeconomic determinants that have a major impact include age, access to credit, farming experience, level of education, access to non-farming income, and access to climate change knowledge. However, gender, family size, and livestock size had no effect on adaptation.
Development of Low-Fat Mayonnaise with Natural Colorant from Tomato Peels Nanopowder
Authors: Evanuarini Herly , Susilo Agus , Amertaningtyas Dedes
Published: January 2024

Tomato peel is an industrial waste product from tomato vegetables that has not been utilized properly. Industrial waste that has not been utilized will harm the environment. Tomato peel is a source of natural food coloring, antioxidants, and a source of fiber. Application of tomato peel can be added to mayonnaise products to improve the color of low-fat mayonnaise. This study aimed to investigate the effect of giving tomato peel nanopowder as a natural coloring in low-fat mayonnaise based on pH, total acid, protein content, carbohydrates, color, and sensory quality. Low-fat mayonnaise was prepared using sunflower oil, vinegar, and egg yolks by giving the tomato peel nanopowder treatment of 0, 1, 2, and 3% which was repeated 5 times. Analysis of variance (ANOVA) was used as data analysis if there were differences in effect between the treatments, followed by Duncan's Multiple Range Test (DMRT). The research results of adding tomato peel nanopowder with different percentages had a very significant effect (p<0.01) on pH, total acid, protein content, carbohydrates, color, and sensory quality. This research concludes that 3% tomato peel nanopowder applied to low-fat mayonnaise can improve pH, total acid, protein content, carbohydrate, L, a*, b*, and sensory quality.