bluuebunny/crossref_metadata_2025 huggingface dataset:
Promoting COVID-19 Vaccination: The Interplay of Message Framing, Psychological Uncertainty, and Public Agency as a Message Source
Authors: Huang Yan , Liu Wenlin
Published: September 2021

The study examines how framing, psychological uncertainty, and agency type influence campaign effectiveness in promoting coronavirus disease 2019 (COVID-19) vaccines. A 2 (gain vs. loss frame) × 2 (high vs. low uncertainty) × 2 (national vs. local agency) between-subjects experiment was conducted among Houston residents ( N = 382). Findings revealed that a loss frame was more effective among participants primed with high uncertainty through a thought-listing task; however, it was less persuasive under conditions of low uncertainty due to increased psychological reactance. Moreover, there was an interaction effect between uncertainty and agency type on vaccine beliefs. The study contributes to the framing literature by identifying psychological uncertainty as a moderator and provides useful suggestions for vaccine message design.
D-dimer Level and Diabetes in the COVID-19 Infection
Authors: Miri Chaymae , Charii Hajar , Bouazzaoui Mohammed-Amine , Laouan Brem Falmata , boulouiz Soumia , Abda Naima , Kouismi Hatim , Bazid Zakaria , Ismaili Nabila , El Ouafi Noha
Published: September 2021

Introduction

Diabetes is the most common of comorbidity in patients with SARS-COV-2 pneumonia. Coagulation abnormalities with D-dimer levels are increased in this disease.

Objectifs

We aimed to compare the levels of D-dimer in diabetic and non-diabetic patients with COVID 19. A link between D-dimer and mortality has also been established.

Materials

A retrospective study was carried out at the University Hospital Center of Oujda (Morocco) from November 01st to December 01st, 2020. Our study population was divided into two groups: a diabetic group and a second group without diabetes to compare clinical and biological characteristics between the two groups. In addition, the receiver operator characteristic curve was used to assess the optimal D-dimer cut-off point for predicting mortality in diabetics.

Results

201 confirmed-COVID-19-patients were included in the final analysis. The median age was 64 (IQR 56-73), and 56% were male. Our study found that D-dimer levels were statistically higher in diabetic patients compared to non-diabetic patients. (1745 vs 845 respectively, P = 0001). D-dimer level > 2885 ng/mL was a significant predictor of mortality in diabetic patients with a sensitivity of 71,4% and a specificity of 70,7%.

Conclusion

Our study found that diabetics with COVID-19 are likely to develop hypercoagulation with a poor prognosis.
The Application of the ThroLy Risk Assessment Model to Predict Venous Thromboembolism in Patients with Diffuse Large B-Cell Lymphoma
Authors: Abdel-Razeq Hikmat , Ma’koseh Mohammad , Mansour Asem , Bater Rayan , Amarin Rula , Abufara Alaa , Halahleh Khalid , Manassra Mohammad , Alrwashdeh Mohammad , Almomani Mohammad , Zmaily Mais
Published: September 2021

Background

Patients with aggressive lymphomas are at higher risk for venous thromboembolism (VTE). ThroLy is a risk assessment model (RAM) derived to predict the occurrence of VTE in various types of lymphomas. In this study, we assess the clinical application of ThroLy RAM in a unified group of patients with diffuse large B-cell lymphoma (DLBCL).

Methods

Hospital databases were searched for patients with DLBCL and radiologically-confirmed VTE. Items in the ThroLy RAM, including prior VTE, reduced mobility, obesity, extranodal disease, mediastinal involvement, neutropenia and hemoglobin < 10.0 g/dL, were retrospectively reviewed.

Results

A total of 524 patients, median age 49 (range: 18-90) years were included. Patients had high disease burden; 57.3% with stage III/IV and 34.0% with bulky disease. All were treated on unified guidelines; 63 (12.0%) had primary refractory disease. Venous thromboembolic events were reported in 71 (13.5%) patients. Among 121 patients with high (> 3) ThroLy score, 22.3% developed VTE compared to 8.4% and 12.4% in those with low and intermediate risk scores, respectively ( P = .014). Simplifying the ThroLy model into two risk groups; high-risk (score ≥ 3) and low risk (score < 3) can still segregate patients; VTE developed in 44 (17.2%) high-risk patients ( n = 256) compared to 27 (10.1%) in the low-risk group ( n = 268), P = .038. Neutropenia, a component of the ThroLy, was encountered in only 14 (2.7%) patients.

Conclusions

ThroLy RAM can identify patients with DLBCL at high risk for VTE. Model can be modified by dividing patients into two, rather than three risk groups, and further simplified by omitting neutropenia.
Lenalidomide-induced arthritis: A case report and review of literature and pharmacovigilance databases
Authors: Icard Charlotte , Mocquot Pauline , Nogaro Jean-Claude , Despas Fabien , Gauthier Martin
Published: September 2021

Introduction

Lenalidomide is an immunomodulatory agent with multiple mechanisms of action, and treatment with lenalidomide is associated with adverse events such as thrombosis and abdominal pain; nonetheless, other rarer adverse events do exist, with few knowledge from physicians and pharmacists. For such adverse events, pharmacovigilance databases are of great interest.

Case report

A 71-year-old patient with no rheumatologic history, in complete remission of a mantle-cell lymphoma following rituximab, doxorubicin, vincristine, cyclophosphamide, and prednisone induction, received a maintenance treatment with rituximab and lenalidomide. After each course of lenalidomide and with no other new medication, the patient presented with fever and high inflammatory markers level, and a scapular-belt arthritis.

Management and outcome

The patient was managed with non-steroidal anti-inflammatory drugs and colchicine, with symptomatology and inflammation improvement. After discontinuation of lenalidomide, he had no arthritis relapse; it was then concluded that the patient had a lenalidomide-induced arthritis. We interrogated the national and international (VigiBase®) pharmacovigilance databases and found that arthritis in the context of lenalidomide exposure is a rare finding, with only three reported cases in France; 0.13% of adverse events reported with lenalidomide in the international database VigiBase® were arthritis.

Discussion

Our case then reports an uncommon finding, of which both pharmacists and physicians should be aware due to the wide and increasing use of lenalidomide.
Health professionals’ attitude and associated factors toward cytotoxic drug handling in University of Gondar specialized hospital: Institution-based cross-sectional study
Authors: Simegn Wudneh , Dagnew Baye , Dagne Henok , Weldegerima Berhanemeskel
Published: September 2021

Background

Studies have shown that cytotoxic drugs are dangerous to health care workers. Health care professionals’ attitude to cytotoxic drugs is vital to apply safety protocols in the prevention of cytotoxicity. The current study aimed to assess health professionals’ desirable attitude and associated factors toward cytotoxic drugs handling in the University of Gondar Specialized Hospital.

Methods

An institution-based cross-sectional study was conducted on 412 health professionals from June to August 2019. Simple random sampling was used to select participants and a self-administered questionnaire was used to collect data. Epi Info and SPSS 20 were used for data entry and analysis, respectively. Variables with a p value < 0.05 were declared as determinants.

Results

The number of health professionals included was approximately 412. The mean age of participants was 29.9 ± 5.4 years. The proportion of participants with desirable attitude toward cytotoxic drugs handling was 224 (54.4%) (95% confidence interval: 51.95–56.85). Male (adjusted odds ratio = 1.69, 95% confidence interval:[1.08–2.65]), work experience of 5–8 years (adjusted odds ratio = 1.92, 95% confidence interval: [1.10–3.34]), weekly working hours of 44–55 (adjusted odds ratio = 2.25, 95% confidence interval: [1.02–4.96]), medium work stress (adjusted odds ratio = 1.67, 95% confidence interval: [1.01–2.69]), and good practice of cytotoxic drug handling (adjusted odds ratio = 1.67, 95% confidence interval: [1.04–2.67]) were significantly associated with the attitude of health professionals.

Conclusion

A significant proportion of health care workers did not have desirable attitude to handle cytotoxic drugs. Thus, strategies are suggested to improve the positive attitude of health professionals to cytotoxic drug handling. Female health professionals, those who had work experience of less than 2 years and those with higher work stress demand special attention.
Hand-foot syndrome and nail disorders secondary to treatment with paclitaxel: Is there a relationship with the presence of fungi?
Authors: Pereira Paulina Patente , Nunes Filho Mário , Moreira Tomaz de Aquino , Duarte Silva Malvino Lucivânia , de Araújo Lúcio Borges , dos Santos Pedroso Reginaldo , Ângela Ribeiro Maria
Published: September 2021

Introduction

This study aimed to evaluate the frequency of nail disorders and the presence of fungi on the nails of the hands and feet of patients with hand-foot syndrome secondary to treatment with paclitaxel.

Methods

Prospective study, carried out from October 2018 to December 2019, which included 81 patients undergoing treatment for breast cancer using paclitaxel and had signs and or symptoms of hand-foot syndrome with or without nail disorders. The data were collected through interviews guided by a structured questionnaire, information from medical records and reports of mycological exams.

Results

The average age of women was 54.7 ± 7.4 years. Nail disorders occurred in 69 patients (85.2%), and of these, 43 (62.3%) were positive for fungi. The fungi were yeasts ( n = 38; 69%), dermatophytes ( n = 15; 27.2%) and non-dermatophyte filamentous fungi ( n = 8; 14.5%).

Conclusions

Nail disorders were the most frequent manifestations in patients with hand-foot syndrome treated with paclitaxel and occurred in 85.2% of them. It was evidenced that fungi are present on the nails of these patients and can occur in up to 65.28%. The most prevalent fungi were Candida and Trichophyton. The nail lesion was associated with the type of treatment protocol used by the patient. The results of the study point to the need to select safe management alternatives for patients, so they can prevent nail lesions and prevent the proliferation of fungi, consequently reducing negative life impact during treatment.
Engaging Latino Families About COVID-19 Vaccines: A Qualitative Study Conducted in Oregon, USA
Authors: Garcia Jonathan , Vargas Nancy , de la Torre Cynthia , Magana Alvarez Mario , Clark Jesse Lawton
Published: October 2021

Objectives

Latinos are disproportionately vulnerable to severe COVID-19 due to workplace exposure, multigenerational households, and existing health disparities. Rolling out COVID-19 vaccines among vulnerable Latinos is critical to address disparities. This study explores vaccine perceptions of Latino families to inform culturally centered strategies for vaccine dissemination.

Method

Semistructured telephone interviews with Latino families (22 mothers and 24 youth, 13–18 years old) explored COVID-19 vaccine perceptions including (1) sources of information, (2) trust of vaccine effectiveness and willingness to get vaccinated, and (3) access to the vaccine distribution. We identified thematic patterns using immersion–crystallization.

Results

We found that (1) 41% expressed optimism and willingness to receive the vaccine coupled with concerns about side effects; (2) 45% expressed hesitancy or would refuse vaccination based on mistrust, myths, fear of being used as “guinea pigs,” and the perceived role of politics in vaccine development; (3) families “digested” information gathered from social media, the news, and radio through intergenerational communication; and (4) participants called for community-led advocacy and “leading by example” to dispel fear and misinformation. Optimistic participants saw the vaccine as a way to protect their families, allowing youth to return to schools and providing safer conditions for frontline essential workers.

Conclusions

Culturally centered vaccine promotion campaigns may consider the Latino family unit as their target audience by providing information that can be discussed among parents and youth, engaging a range of health providers and advocates that includes traditional practitioners and community health workers, and disseminating information at key venues, such as schools, churches, and supermarkets.
Massive retinal infiltrates as the presenting sign of chronic myeloid leukemia: Clinical and imaging features of leukemic retinopathy
Authors: Szeto Simon KH , Mohamed Shaheeda , Tsang Chi Wai , Chan Carmen KM
Published: October 2021

Purpose:

To describe the clinical and optical coherence tomography (OCT) features of two cases with bilateral diffuse retinal infiltrates as the only presenting feature of chronic myeloid leukemia (CML) on initial diagnosis and upon relapse.

Methods:

We reported two patients with CML, one at initial diagnosis and one in remission who presented with bilateral subacute visual impairment. Fundal examination revealed bilateral symmetrical leukostatic appearance with increased vascular tortuosity, diffuse retinal infiltrates with size up to 6 disk diameters, retinal hemorrhages, and Roth’s spots. OCT showed multiple intra-retinal hyper-reflective foci corresponding to intra-retinal hemorrhages, and outer retinal hyper-reflective foci in area corresponding to retinal infiltrate. The different retinal layers were relatively preserved and distinguishable.

Results:

White cell count (WCC) were elevated in both patients ranging from 544 to 810 × 109/L. Bone marrow biopsy confirmed the diagnosis of CML in the patient without prior diagnosis and relapse of CML in another patient. Cytogenetic test detected Abelson murine leukemia (ABL) – breakpoint cluster region (BCR) fusion transcript in both cases. Both patients were started on oral imatinib, subsequently WCC returned to within normal values in both cases. Vision and OCT abnormalities improved and reduction in retinal hemorrhages and infiltrates were observed in follow up.

Conclusion:

This report highlights the important role of ophthalmologists and detailed fundus examination in making a prompt diagnosis of leukemia in patients with visual complaints. Appropriate systemic investigation and hematologist referrals for prompt treatment of CML may improve survival rate and preserve vision.
Dialysis access graft occlusion with contrast and ultrasound guided thrombin injection for intractable arm edema and pseudoaneurysm
Authors: Diego Pinto , Fabián Montalvo , Constanza Melendez , Mirna Lapadula , Martin Perez
Published: September 2021

We present the case of a patient with a brachio-basilic graft forearm loop with intractable edema and thrombosed central veins. She showed up with an important edema after some effort and a previously thrombosed pseudoaneurysm with significant growth. She refused angioplasty treatment for central veins, the graft had not been used for dialysis during the last year, so that arteriovenous graft (AVG) ligation was considered. Due to local conditions thrombin percutaneous embolization was performed to avoid possible complications of a conventional surgery approach. AVG occlusion was done in 10 min by fluoroscopy and ultrasound guidance. In 24 h the patient was significantly better and after 1 week she had no edema at all. There were no complications and no recanalization was observed after 3 months. Percutaneous thrombin embolization is a safe and effective technique for AVG occlusion in case of intractable arm edema with central vein thrombosis, and most likely to be considered in other situations where arteriovenous graft or fistula ligature is needed.
Rural and Urban Correlates of Stunting Among Under-Five Children in Sierra Leone: A 2019 Nationwide Cross-Sectional Survey
Authors: Sserwanja Quraish , Kamara Kassim , Mutisya Linet M , Musaba Milton W , Ziaei Shirin
Published: September 2021

Background:

Undernutrition accounts for at least 50% of the annual global under-five mortality burden. Although disparities in the childhood stunting between urban and rural areas in Sierra Leone have been documented, information on factors associated with these differences is lacking. We aimed to determine rural-urban correlates of stunting among children under the age of 5 in Sierra Leone.

Methods:

We analyzed data from 2019 Sierra Leone demographic and health survey (SLDHS) focusing on under-five children. We conducted multivariable logistic regression to examine rural-urban factors associated with childhood stunting.

Results:

Prevalence of stunting was 31.6% (95% CI 29.8-33.2) in rural areas and 24.0% (95% CI 21.6-26.1) in urban areas. Within the rural areas, children of stunted mothers (aOR = 2.37; 95% CI 1.07-5.24, P < .05), younger mothers aged 15 to 19 years (aOR = 2.08; 95% CI 1.17-3.69, P < .05), uneducated mothers (aOR = 1.87; 95% CI 1.28-2.71, P < .01), as well as older children (24-59 months) (aOR = 1.83; 95% CI 1.48-2.27, P < .001), and boys (aOR = 1.37; 95% CI 1.12-1.66, P < .01) were more likely to be stunted compared to those of non-stunted, older, post-primary education mothers and those who were less than 24 months and girls respectively. While urban children whose fathers had lower education (aOR = 1.94; 95% CI 1.10-3.42, P < .05), whose mothers were more parous (para 2-4) (aOR = 1.74; 95% CI 1.03-2.95, P < .05), and boys (aOR = 1.48; 95% CI 1.06-2.08, P < .05) were more likely to be stunted compared to their counterparts with fathers that had tertiary education, mothers of low parity and girls, respectively.

Conclusions:

Stunting is more prevalent in the rural areas compared to the urban areas. Sex of the child was the only significant factor in both rural and urban areas. Our study findings suggest that programs designed to reduce stunting should aim for integrated yet context specific interventions in rural and urban areas.
Animal activism in the business school: Using fierce compassion for teaching critical and positive perspectives
Authors: Tallberg Linda , Välikangas Liisa , Hamilton Lindsay
Published: October 2021

This article explores a practical approach to teaching animal ethics in food systems as part of a business course. We argue that tackling such complex and emotionally charged topics is vital to shifting unsustainable and hurtful behaviours towards more positive futures. Our teaching example outlines a pedagogy of courageously witnessing, inquiring with empathy and prompting positive action; an activist approach we term fierce compassion. These three layers blend positive and critical perspectives in a classroom to address contentious issues of large-scale industrial animal production hitherto largely neglected in a traditional business curriculum. While acknowledging that academic activism is controversial, we argue that fierce compassion – noticing the suffering that is remote and often systemically hidden – can inform and structure education towards more post-anthropocentric and just futures for all living beings – human and nonhuman alike.
The clinical features of combined central and peripheral demyelination and antibodies against the node of Ranvier
Authors: Hou Xiaodan , Liang Yan , Cui Pan , Hao Junwei
Published: October 2021

Background:

Combined central and peripheral demyelination (CCPD) is a disease of inflammatory demyelination that affects central and peripheral nerves simultaneously or temporally separated.

Objectives:

This study evaluated the clinical characteristics and the existence of antinodal/paranodal antibodies in patients with CCPD.

Methods:

We reviewed the clinical manifestations, laboratory tests, electrophysiological examinations, neuroimaging findings, treatment, and prognosis of 31 patients with CCPD. Using a live cell–based assay, we tested antinodal/paranodal antibodies.

Results:

The most common symptoms were motor weakness (83.3%), hyporeflexia (63.3%), and sphincter disturbance (58.1%). In total, 16.6% of patients had impaired vision symptoms, whereas 33.3% of patients had abnormal visual-evoked potentials (VEPs). A total of 21.1% (4/19) of patients were positive for anti-AQP4 (aquaporin 4) antibodies, 20.0% (2/10) of patients were positive for anti-NF155 (neurofascin-155) antibodies, and 10.0% (1/10) of patients were positive for anti-MAG (myelin-associated glycoprotein) antibodies. The effective rates of intravenous corticosteroids, intravenous immunoglobulins, and rituximab were 72.2%, 37.5%, and 100%, respectively. At the illness peak, 75% of patients with CCPD had an mRS (modified Rankin Scale) score of 4 or greater. In remission, 37.5% had an mRS score of 4 or greater.

Conclusion:

The clinical manifestations of patients with CCPD are highly heterogeneous. We recommend testing antinodal/paranodal antibodies for patients with CCPD.
Free From Falls education and exercise program for reducing falls in people with multiple sclerosis: A randomized controlled trial
Authors: Cameron Michelle H , Hildebrand Andrea , Hugos Cinda L , Judd Grace I , McMillan Garnett , Jacobs Peter G
Published: October 2021

Background:

People with multiple sclerosis (PwMS) fall frequently. Community-delivered exercise and education reduce falls in older adults, but their efficacy in multiple sclerosis (MS) is unknown.

Objectives:

To evaluate the impact of the Free From Falls (FFF) group education and exercise program on falls in PwMS.

Methods:

This was a prospective, assessor-blinded, two-arm parallel randomized controlled trial. Ninety-six participants were randomized to FFF (eight weekly 2 hour sessions) or the control condition (a fall prevention brochure and informing their neurologist of their fall history). Participants counted falls prospectively from enrollment through 6 months following intervention. Effects on fall frequency were evaluated by the Bayesian analysis.

Results:

The modeled mean fall frequency pre-intervention was 1.2 falls/month in the FFF group (95% credible intervals (CIs) = 0.8–2.0) and 1.4 falls/month in the control group (95% CI = 0.9–2.1). Fall frequency decreased by 0.6 falls/month in both groups over time (nadir 4–6 months post-intervention: FFF 0.6 falls/month (95% CI = 0.4–0.9); control 0.8 falls/month (95% CI = 0.5–1.1)).

Conclusion:

In-person group exercise and education are not superior to written education and neurologist-initiated interventions for preventing falls in PwMS.
Telemedicine in paediatric emergency care: A systematic review
Authors: Mitra Aditi , Veerakone Rubina , Li Kathleen , Nix Tyler , Hashikawa Andrew , Mahajan Prashant
Published: September 2021

Introduction

The impact of telemedicine on the access and quality of paediatric emergency care remains largely unexplored because most studies to date are focused on adult emergency care. We performed a systematic review of the literature to determine if telemedicine is effective in improving quality of paediatric emergency care with regards to access, process measures of care, appropriate disposition, patient-centred outcomes and cost-related outcomes.

Methods

We developed a systematic review protocol in accordance with PRISMA (Preferred Reporting Items for Systematic Review) guidelines. We included studies that evaluated the impact of synchronous and asynchronous forms of telemedicine on patient outcomes and process measures in the paediatric emergency care setting. Inclusion criteria were study setting, study design, intervention type, age, outcome measures, publication year and language.

Results

Overall, 1.9% (28/1434) studies met study inclusion and exclusion criteria. These studies revealed that telemedicine increased accuracy of patient assessment in the pre-clinical setting, improved time-to disposition, guided referring emergency department (ED) physicians in performing appropriate life-saving procedures and led to cost savings when compared to regular care. Studies focused on telepsychiatry demonstrated decreased length of stay (LOS), transfer rates and improved patient satisfaction scores.

Discussion

Our comprehensive review revealed that telemedicine enhances paediatric emergency care, enhances therapeutic decision-making and improves diagnostic accuracy, and reduces costs. Specifically, telemedicine has its most significant impact on LOS, access to specialized care, cost savings and patient satisfaction. However, there was a relative lack of randomized control trials, and more studies are needed to substantiate its impact on morbidity and mortality.
Victims, perpetrators, scapegoats and Russian dolls: Narrating violence within secure units for adolescents from a staff perspective
Authors: Andersson Peter
Published: October 2021

A rise of violent incidents at secure units for adolescents has been reported by the Swedish National Board of Institutional Care. Meanwhile, research aiming to understand how staff manage violence seems to be lacking. By examining an in-depth narrative by one staff member, “Meral”, this study aims to understand, on the one hand, how staff describe the violence they encounter in light of the context and situation, and on the other, how they describe their handling of violence from outside the immediate environment. Drawing on Georgakopoulou and Bamberg, identities are understood to be produced and performed within personal narratives from different positions in relation to one’s surroundings. The study shows how Meral’s professional identity is shaped and affected by violence. Of essential importance is the way Meral presents herself to herself: as “not afraid.” A narrative interpretation is that fear does not fit within the framework of the professional identity for staff. A key element of placing essential responsibility on staff to manage violence is keeping lines of communication open, which could be made clearer in policy documents, training and supervision. Therefore, studies like this one could result in the development of communication strategies for staff. This is important because emotional rules can generate emotional cultures that in the long run can be destructive for both staff and young people. Only when the emotional rules are identified can staff develop strategies for dealing with the violent incidents that are part of their professional life in a qualified way.
Participatory Monitoring and Evaluation of the COVID-19 Response in a Local Public Health System
Authors: Holt Christina M. , Fawcett Stephen B. , Hassaballa-Muhammad Ruaa , Partridge Dan , Jordan Sonia
Published: September 2021

The coronavirus disease 2019 (COVID-19) pandemic tested the capacity of local health systems to understand and respond to changing conditions. Although data on new cases of COVID-19 were widely shared in communities, there was less information on the multisector response activities and factors associated with implementation. To address this gap, this empirical case study examined (a) the pattern of implementation of COVID-19 response activities and (b) the factors and critical events associated with both the pattern of new cases and the implementation of the local COVID-19 response. We used a participatory monitoring and evaluation system to capture, code, characterize, and communicate 580 COVID-19 response activities implemented in the city of Lawrence and Douglas County, Kansas. Collaboration across sectors including public health, medical services, city/county government, businesses, social services, public schools, and universities enabled the local public health system’s response effort. Documentation results showed the varying pattern of new COVID-19 cases and response activities over time and the factors identified as enabling or impeding the response and related new cases. Similar participatory monitoring and evaluation methods can be used by local health systems to help understand and respond to the changing conditions of COVID-19 response and recovery.
Effects of a Coaching Intervention on Paraeducator Use of Aided Language Modeling in Classroom Settings: A Pilot Investigation
Authors: Kashinath Shubha , Dukhovny Elena , Polit Prema
Published: September 2021

Paraeducators are the most frequent communication partners during the school day for students who use augmentative and alternative communication (AAC), yet they often lack training in AAC best practices. This intervention study examined the effect of an in-class coaching intervention on the aided language modeling (ALM) skills of paraeducators who work with students who use AAC. An intervention protocol using evidence-based coaching strategies was used to support paraeducator implementation of ALM in typical classroom activities. The multiple-baseline single-subject design measured the use of ALM by four paraeducators. Data were analyzed visually and by calculating Tau- U and gain scores. Results suggest a strong effect from the coaching intervention on ALM skills for each of the paraeducators. Challenges and benefits of paraeducator-focused interventions in classroom settings are presented.
Non-pegylated Liposomal Doxorubicin as Palliative Chemotherapy in pre-Treated Advanced Pancreatic Cancer: A Retrospective Analysis of Twenty-Eight Patients
Authors: Schlick Konstantin , Kiem Dominik , Huemer Florian , Neureiter Daniel , Weiss Lukas , Greil Richard
Published: October 2021

Background: Pancreatic cancer carries a devastating prognosis and is the fourth leading cause for cancer-related death in the United States and most European countries. Although one-third of patients receive a palliative third line therapy, the benefit of systemic therapy beyond second-line remains unclear. A plethora of clinical trials investigating novel drugs have failed over the past years. Due to the lack of established treatment regimens beyond second line, we offered nonpegylated liposomal doxorubicin, well known in other tumor entities, to pretreated pancreatic cancer patients requesting systemic therapy. Material and Methods: In this retrospective analysis, 28 patients with pancreatic carcinoma treated with nonpegylated liposomal doxorubicin (Myocet®) between 2012 and 2018 at our department were included. Results: For the majority of patients (n = 18, 64%), nonpeglyted liposomal doxorubicin was offered as a third-line therapy. Five patients received it as second line, four patients as fourth line, and one patient as fifth line of therapy. Half of the patients received at least a therapy cycle. The objective response rate to treatment was 7.1%. One patient had a period of radiologically confirmed stable disease with stable tumor markers. Another patient experienced partial remission. Conclusion: According to our findings the benefit of nonpegylated liposomal doxorubicin in pancreatic cancer beyond second line is limited.
Inhibition of Glutamine Uptake Improves the Efficacy of Cetuximab on Gastric Cancer
Authors: Ma Huanrong , Wu Jingjing , Zhou Minyu , Wu Jianhua , Wu Zhenzhen , Lin Li , Huang Na , Liao Wangjun , Sun Li
Published: September 2021

Treatment for advanced gastric cancer is challenging. Epidermal growth factor receptor (EGFR) contributes to the proliferation and development of gastric cancer (GC), and its overexpression is associated with unfavorable prognosis in GC. Cetuximab, a monoclonal antibody targeting EGFR, failed to improve the overall survival of gastric cancer patients indicated in phase III randomized trials. Glutamine is a vital nutrient for tumor growth and its metabolism contributes to therapeutic resistance, making glutamine uptake an attractive target for cancer treatment. The aim of the present study was to investigate whether intervention of glutamine uptake could improve the effect of cetuximab on GC. The results of MTT assay showed that by glutamine deprivation or inhibition of glutamine uptake, the viability of gastric carcinoma cells was inhibited more severely than that of human immortal gastric mucosa epithelial cells (GES-1). The expression of the key glutamine transporter alanine-serine-cysteine (ASC) transporter 2 (ASCT2; SLC1A5) was significantly higher in gastric carcinoma tissues and various gastric carcinoma cell lines than in normal gastric tissues and cells, as shown by immunohistochemistry and western blotting, while silencing ASCT2 significantly inhibited the viability and proliferation of gastric carcinoma cells. Consistent with previous studies, it was shown herein by MTT and EdU assays that cetuximab had a weak inhibitory effect on the cell viability of gastric carcinoma cells. However, inhibiting glutamine uptake by blockade of ASCT2 with l-γ-glutamyl- p-nitroanilide (GPNA) significantly enhanced the inhibitory effect of cetuximab on suppressing the proliferation of gastric cancer both in vitro and in vivo. Moreover, combining cetuximab and GPNA induced cell apoptosis considerably in gastric carcinoma cells, as shown by flow cytometry, and had a higher depressing effect on gastric cancer proliferation both in vitro and in vivo, as compared to either treatment alone. The present study suggested that inhibition of glutamine uptake may be a promising strategy for improving the inhibitory efficacy of cetuximab on advanced gastric cancer.
Three-dimensional analysis model of electric heating fabrics considering the skin metabolism
Authors: Li Xiao , Kuai Bo , Tu Xikai , Tan Jiahao , Zhou Xuan
Published: September 2021

In low temperature environment, electric heating clothing can provide extra heat for human body through built-in heat source, so it has better thermal insulation effect. The thermal analysis is the initial step for electric heating clothing design. The current thermal analysis of electric heating textiles focuses on the fabric itself instead of the effect of skin tissue metabolism and heat production. In order to improve the accuracy of skin surface temperature prediction, the biological heat transfer need be modeled to analyze the internal temperature distribution of the heating suit system. In this paper, a three-dimensional (3D) thermal analysis model of electric heating clothing combined with human skin tissue is established. Firstly, the coupling analysis of Fourier heat conduction and Pennes biological heat transfer equation is carried out. Then the reliability of the 3D thermal analysis model is verified by finite element analysis (FEA). The results show that the fitting error between the three-dimensional model analysis data and FEA simulation data is 5°C, which proves that the model can accurately predict the system temperature. Finally, we make further research about the effects of ambient temperature, clothing layer thickness, and input power on the maximum skin surface temperature. This study provides theoretical foundation for the design of wearable thermal management fabric.
Experiences of Educational Researchers in the Use of the Case Study Design During the Covid-19 Pandemic: Lessons From a South African Rural Setting
Authors: Mabasa Layane Thomas , Themane Mahlapahlapana Johannes
Published: September 2021

This article explores the usefulness of the case study design in the creation of educational knowledge during uncertain times such as wars, disease outbreaks, famine, and pandemics, including Covid-19 pandemic. This is done at a time when others still doubt its contribution to the creation of knowledge. They criticize it for among other things, its lack of robustness and, its dependency on single case occurrences. In the current Covid-19 pandemic circumstances, further advantages of its application may be highlighted. Thus, the question is: to what extent does a case study design contribute toward knowledge creation during uncertain times? This article reflects on the experiences of educational researchers in using the case study design and its contribution to the creation of knowledge during the Covid-19 pandemic in a rural South African setting. Data was generated through semi-structured interviews with four researchers who were purposively selected to participate in the study and was analyzed by developing categories and themes. Despite the constraints imposed by the pandemic, such as the inaccessibility of participants during data creation, the case study design proved to be a suitable alternative approach. The article argues that the use of the case study design is appropriate during uncertain times because of its flexibility and plausibleness. This includes, the understanding of the dynamic nature of the Covid-19 pandemic, and its management. For example, the case study design enables researchers to highlight the unique nature of different contexts created by the Covid-19 pandemic. It might also assist researchers in assessing and constructing additional data while observing social distancing. The implication of the study is that researchers need to consider the use of the case design in dealing with emergent issues. It may also help policy makers in the understanding and management of future public health advocacy campaigns regarding Covid-19 pandemic.
Methodological and Practical Considerations in Rapid Qualitative Research: Lessons Learned From a Team-Based Global Study During COVID-19 Pandemic
Authors: Luciani Michela , Strachan Patricia H. , Conti Alessio , Schwartz Lisa , Kapiriri Lydia , Oliphant Allyson , Nouvet Elysée
Published: October 2021

Rapid qualitative research (RQR) studies are increasingly employed to inform decision-making in public health emergencies. Despite this trend, there remains a lack of clarity around what these studies actually involve in terms of methodological processes and practical considerations or challenges. Our team conducted a global RQR study during the COVID-19 pandemic. In this article, we provide a detailed account of our methodological processes and decisions taken related to ethics, study design, and analysis. We describe how we navigated limitations on time and resources. We draw attention to several elements that operated as facilitators to the rapid launch and completion of this study. Rendering methodological considerations and rationales for specific RQR studies explicit and available for consideration by others can contribute to the validity of RQR, support further discussion and development of RQR methods, and make findings for particular studies more credible.
Analysis and experimental research on motion stability of wall-climbing robot with double propellers
Authors: Liang Peng , Gao Xueshan , Zhang Qingfang , Li Mingkang , Gao Rui , Xu Yuxin
Published: September 2021

This paper presents a wall-climbing robot which can stably hold and move on the ground-wall surface. The robot uses propeller reverse thrust as an adsorption force and can adapt to the surface of several media materials. The influence of the robot’s structural parameters on its power system is analyzed by comparing a single power system test and a robot prototype power test. A structural analysis of the robot is performed under two specific situations; when he is in transition from the ground to a small slope, and when he is on the slope. The force state of the robot is then obtained in different conditions. Experimental results show that the adjustment range of different rotor inclination angles of the robot, the width of the fixed rotor plate and the different near-ground distances, affect the traction of the robot. The robot motion performance and adaptability under different ground/wall environments are analyzed, by conducting the robot climbing experiment under a small slope, a vertical wooden wall surface and a vertical indoor wall surface. Stable adsorption and optimization tests are also performed. Moreover, the stability of the robot’s motion is verified. Finally, a theoretical and experimental accumulation is laid for the realization of the smooth transition of the robot from the ground to the wall.
Similarity model for predicting the performance of an R718 compressor
Authors: Son Yong-Jin , Suh Jun-Won , Yang Hyeonmo , Lee Kyoung-Yong , Lee Si-Woo , Yoon Joonyong , Choi Young-Seok
Published: September 2021

A general compression refrigeration system consists of a compressor, condenser, pressure-reducing valve, and evaporator to induce phase changes in the refrigerant. The performance of the compression refrigeration system strongly depends on the type and characteristics of the refrigerant. However, synthetic refrigerants such as chlorofluorocarbon, hydrochloro-fluorocarbon, and hydrofluorocarbon directly affect the environment as greenhouse gases and indirectly affect the environment by generating substances as they decompose. Thus, researchers have been focusing on developing refrigerants with a low or zero global warming potential. R718 (i.e. water) is an ecofriendly refrigerant, but its specific volume rapidly changes between the liquid and gas phases. This requires making the components of the compression refrigeration system larger than normal to accommodate these volume changes, which is inefficient for manufacturing prototypes. In this study, an alternative refrigerant was applied to the design of a centrifugal compressor that uses R718 as the working fluid. To address the volume change of R718, a numerical analysis was conducted by using the similarity method, where the size of the impeller was reduced and the rotational speed was controlled. To ensure the reliability of the similarity model, its results were compared against the experimental data of the original model for verification.
Psychological Science in the Wake of COVID-19: Social, Methodological, and Metascientific Considerations
Authors: Rosenfeld Daniel L. , Balcetis Emily , Bastian Brock , Berkman Elliot T. , Bosson Jennifer K. , Brannon Tiffany N. , Burrow Anthony L. , Cameron C. Daryl , Chen Serena , Cook Jonathan E. , Crandall Christian , Davidai Shai , Dhont Kristof , Eastwick Paul W. , Gaither Sarah E. , Gangestad Steven W. , Gilovich Thomas , Gray Kurt , Haines Elizabeth L. , Haselton Martie G. , Haslam Nick , Hodson Gordon , Hogg Michael A. , Hornsey Matthew J. , Huo Yuen J. , Joel Samantha , Kachanoff Frank J. , Kraft-Todd Gordon , Leary Mark R. , Ledgerwood Alison , Lee Randy T. , Loughnan Steve , MacInnis Cara C. , Mann Traci , Murray Damian R. , Parkinson Carolyn , Pérez Efrén O. , Pyszczynski Tom , Ratner Kaylin , Rothgerber Hank , Rounds James D. , Schaller Mark , Silver Roxane Cohen , Spellman Barbara A. , Strohminger Nina , Swim Janet K. , Thoemmes Felix , Urganci Betul , Vandello Joseph A. , Volz Sarah , Zayas Vivian , Tomiyama A. Janet
Published: October 2021

The COVID-19 pandemic has extensively changed the state of psychological science from what research questions psychologists can ask to which methodologies psychologists can use to investigate them. In this article, we offer a perspective on how to optimize new research in the pandemic’s wake. Because this pandemic is inherently a social phenomenon—an event that hinges on human-to-human contact—we focus on socially relevant subfields of psychology. We highlight specific psychological phenomena that have likely shifted as a result of the pandemic and discuss theoretical, methodological, and practical considerations of conducting research on these phenomena. After this discussion, we evaluate metascientific issues that have been amplified by the pandemic. We aim to demonstrate how theoretically grounded views on the COVID-19 pandemic can help make psychological science stronger—not weaker—in its wake.
Case series: MRD negativity assessment using 11C-Acetate PET with 3-weekly daratumumab-based quadruplet induction in newly diagnosed multiple myeloma
Authors: Ngai Cheong , Kumar Shaji , Chi-lai Ho Garrett , Chen Sirong , Chim Chor-sang
Published: September 2021

Complete response (CR) is an important favorable factor for survival in multiple myeloma (MM). However, CR patients continue to relapse, especially in the presence of minimal residual disease (MRD). Bone marrow (BM) MRD is predictive of progression-free survival (PFS) in MM. However, myeloma outside the BM aspiration site may result in subsequent relapse despite MRD-negativity. Therefore, positron emission tomography-computed tomography (PET-CT) based on F-fluorodeoxyglucose (FDG) is a complementary tool to monitor residual disease in MM. However, FDG may miss myeloma lesions that are not FDG-avid. On the other hand, 11C-Acetate (ACT) has been found to be a more sensitive and specific tracer than FDG in MM. Recently, the addition of daratumumab to bortezomib, thalidomide, dexamethasone (VTd) or bortezomib, lenalidomide, dexamethasone (VRd) backbone has been proven to improve outcomes. Herein, we report three newly-diagnosed MM patients achieving deep responses with imaging CR using ACT PET in addition to conventional immunofixation CR and MRD-negative CR after a 3-weekly daratumumab-based quadruplet induction regimen.
Lytic parasitic: a case of bone destructing echinococcosis
Authors: Govindasamy Avaan , Bhattarai Pushpa Raj , John Jeff
Published: September 2021

Pelvic hydatid bone disease is a rare and debilitating condition. Patients often present with symptoms and signs when the disease process is advanced and curative resection is not possible. We present a case of destructive bone hydatid disease affecting the left iliac bone. A 45-year-old woman presented initially 5 years ago with a left pelvic mass to the gynaecology department. Computed tomography (CT) scan done at that time showed a large pelvic, left iliac fossa cystic mass with the destruction of the left iliac bone. Extension of the cystic mass transversed the iliac bone into the posterior soft tissue. Percutaneous biopsy taken showed hydatid cystic disease. The patient was planned for surgery and, however, was lost to follow-up. Four years later, she presented with a history of worsening left pelvic pain with an enlarging, left pelvic mass, and another mass in the posterior gluteal area. In addition, CT imaging showed extensive left iliac bone destruction with posterior soft tissue extension to the gluteus muscle. A multidisciplinary team concluded that complete excision would not result in cure. Thus, complete iliac wing bone reconstruction was not an option in this patient. Instead, palliative measures were deemed in the patient’s best interest to control disease progression and relieve painful pressure-related symptoms from the hydatid cystic mass. The patient received preoperative albendazole and underwent an extraperitoneal debulking of the soft tissue hydatid infiltration and debridement of bony fragments from left iliac bone destruction. Postoperatively, the patient did well, and her main complaint of pain related to the cystic mass pressure had improved significantly.
A case of venlafaxine-induced angioedema in an older adult
Authors: Griffin Hailee , Pearson Scott , Linnebur Sunny , Fixen Danielle
Published: September 2021

Angioedema is a serious adverse event that can manifest as lower extremity edema, face swelling, rash, hives, and a swollen tongue, which can sometimes lead to airway constriction and death. It is a well-documented reaction within the angiotensin-converting enzyme inhibitor drug class, where the bradykinin pathway leads to angioedema. We report a case where a patient experienced angioedema after taking venlafaxine. We evaluated other antidepressants as potential treatment options for the patient. We further examined potential cross-reactivity between antidepressants in order to find alternative medications for patients that experience serious adverse effects.