bluuebunny/crossref_metadata_2025 huggingface dataset:
Emerging Roles of RNA-Binding Proteins in Seed Development and Performance
Authors: Lou Lijuan , Ding Ling , Wang Tao , Xiang Yong
Published: September 2020

Seed development, dormancy, and germination are key physiological events that are not only important for seed generation, survival, and dispersal, but also contribute to agricultural production. RNA-binding proteins (RBPs) directly interact with target mRNAs and fine-tune mRNA metabolism by governing post-transcriptional regulation, including RNA processing, intron splicing, nuclear export, trafficking, stability/decay, and translational control. Recent studies have functionally characterized increasing numbers of diverse RBPs and shown that they participate in seed development and performance, providing significant insight into the role of RBP–mRNA interactions in seed processes. In this review, we discuss recent research progress on newly defined RBPs that have crucial roles in RNA metabolism and affect seed development, dormancy, and germination.
Inspection and Assessment of Corrosion in Pretensioned Concrete Bridge Girders Exposed to Coastal Climate
Authors: Osmolska Magdalena J. , Hornbostel Karla , Kanstad Terje , Hendriks Max A.N. , Markeset Gro
Published: September 2020

The most common methods for detecting chloride-induced corrosion in concrete bridges are half-cell potential (HCP) mapping, electrical resistivity (ER) measurements, and chloride concentration testing, combined with visual inspection and cover measurements. However, studies on corrosion detection in pretensioned structures are rare. To investigate the applicability and accuracy of the above methods for corrosion detection in pretensioned bridge girders, we measured pretensioned I-shaped girders exposed to the Norwegian coastal climate for 33 years. We found that, even combined, the above methods can only reliably identify general areas with various probabilities of corrosion. Despite severe concrete cracking and high chloride content, only small corrosion spots were found in strands. Because HCP cannot distinguish corrosion probability in the closely spaced strands from other electrically connected bars, the actual condition of individual strands can be found only when concrete cover is locally removed. Wet concrete with high chloride content and accordingly low HCP and low ER was found only in or near the girder support zones, which can therefore be considered the areas most susceptible to chloride-induced corrosion. We conclude by proposing a procedure for the inspection and assessment of pretensioned girders in a marine environment.
Behavior of a Two-Way Lightweight Steel–Concrete Composite Slab Voided with Thin-Walled Core Boxes towards Sustainable Construction
Authors: Huang Yongqi , Gan Vincent J.L. , Chen Huaguo , Yang Jianjun
Published: September 2020

High-performance engineered structural systems are crucial for sustainable development in the field of construction. In our previous research, a novel steel–concrete composite beam with transverse and longitudinal hidden girders exhibited good flexural behavior and desirable ductility. However, there is a dearth of studies on the flexural response of a steel–concrete composite slab voided with thin-walled core boxes. Therefore, in this study, we investigated the overarching flexural mechanism of the proposed structure when subjected to uniform vertical loads. The experimental detection results illustrated that the deflection value of the composite beam was 95.75% less than the GB/T 50152-2012 recommendation. Numerical results further validated this observation. The recorded data from the strain profile at the mid-span of the frame girder indicated that there was a considerable membrane effect, which delayed the strain growth of rebars, yielding appreciable bearing capacity. Thus, two original approaches to predicting the ultimate load of this novel structure are proposed, considering limit analysis using the upper-bound method and the membrane effect, with the latter closely linked to the experimental results. The findings can promote the extensive application of similar sustainable systems and inspire further advancements in advanced engineering structures.
Ivanov’s Theorem for Admissible Pairs Applicable to Impulsive Differential Equations and Inclusions on Tori
Authors: Andres Jan , Jezierski Jerzy
Published: September 2020

The main aim of this article is two-fold: (i) to generalize into a multivalued setting the classical Ivanov theorem about the lower estimate of a topological entropy in terms of the asymptotic Nielsen numbers, and (ii) to apply the related inequality for admissible pairs to impulsive differential equations and inclusions on tori. In case of a positive topological entropy, the obtained result can be regarded as a nontrivial contribution to deterministic chaos for multivalued impulsive dynamics.
Construction of Fuzzy Measures over Product Spaces
Authors: Reche Fernando , Morales María , Salmerón Antonio
Published: September 2020

In this paper, we study the problem of constructing a fuzzy measure over a product space when fuzzy measures over the marginal spaces are available. We propose a definition of independence of fuzzy measures and introduce different ways of constructing product measures, analyzing their properties. We derive bounds for the measure on the product space and show that it is possible to construct a single product measure when the marginal measures are capacities of order 2. We also study the combination of real functions over the marginal spaces in order to produce a joint function over the product space, compatible with the concept of marginalization, paving the way for the definition of statistical indices based on fuzzy measures.
Emergence of Natural Killer Cell Large Granular Lymphocytes during Gilteritinib Treatment in Acute Myeloid Leukemia with FLT3-ITD Mutation
Authors: Izumi Shintaro , Minami Yosuke , Masuda Shinichi , Utsu Yoshikazu , Sakaida Emiko , Aotsuka Nobuyuki
Published: September 2020

As the potent, selective Fms-Like Tyrosine Kinase 3 (FLT3) inhibitor gilteritinib has only been approved for use for a few years, its efficacy and complications remain incompletely understood. We herein report an elderly patient with FLT3 internal tandem duplications (FLT3-ITD) mutated acute myeloid leukemia (AML) who developed natural killer cell large granular lymphocytes (NK-LGL) in the bone marrow and peripheral blood during gilteritinib treatment. Case: A 79-year-old Japanese female had been diagnosed with FLT3-ITD-mutated AML. The patient received hydroxycarbamide 2000 mg daily for induction chemotherapy but did not achieve remission at day 28 postinduction. The treatment was then changed to gilteritinib 120 mg daily. Although the reduction of blasts in peripheral blood occurred immediately, it was revealed abnormal lymphocytes with large granules developed in bone marrow and peripheral blood. These lymphocytes were analyzed by flow cytometry, which revealed that these cells were NK-LGL because they expressed CD2, CD7, CD16, and CD56 and did not express CD3, CD19, and CD20. The patient achieved partial remission (PR) in a month with gilteritinib treatment. Leukemia eventually could not be controlled, but PR persisted for about 4 months and leukemia was controlled for 4 months after progression disease (PD) with gilteritinib treatment alone. Conclusion: Gilteritinib may induce the NK-LGL. The exact mechanism and effect of LGL in patients with FLT3 mutated AML treated with gilteritinib warrants further investigation.
Computer Vision Tool-Setting System of Numerical Control Machine Tool
Authors: Hou Bo , Zhang Congpeng , Yang Shoubo
Published: September 2020

An automatic tool-setting and workpiece online detecting system was proposed to study the key technologies of next-generation intelligent vision computerized numerical control (CNC) machines. A computer vision automatic tool-setting system for a CNC machine was set up on the basis of the vision tool-setting principle. A rapid vision calibration method based on the position feedback from the CNC machine was proposed on the basis of the theory of traditional vision system calibration. The coordinate mapping relationship of the image and the CNC machine, the tool-setting mark point on the workpiece, and the tool tip were calibrated. The vision system performance testing and system calibration experiments were performed. Experimental results indicated that the time consumption was 128 ms in image processing. The precision of tool setting and measuring was less than 1 μm. The workpiece positioning and processing online detection function of the system can completely meet the requirements of visual CNC machine application, and the system has wide application prospects.
Pressure Sensitive Adhesive Tape: A Versatile Material Platform for Optical Sensors
Authors: Barrios Carlos Angulo
Published: September 2020

Pressure sensitive adhesive (PSA) tapes are a versatile, safe and easy-to-use solution for fastening, sealing, masking, or joining. They are widely employed in daily life, from domestic use to industrial applications in sectors such as construction and the automotive industry. In recent years, PSA tapes have found a place in the field of micro- and nanotechnology, particularly in contact transfer techniques where they can be used as either sacrificial layers or flexible substrates. As a consequence, various optical sensing configurations based on PSA tapes have been developed. In this paper, recent achievements related to the use of PSA tapes as functional and integral parts of optical sensors are reviewed. These include refractive index sensors, optomechanical sensors and vapor sensors.
ARIES: A Novel Multivariate Intrusion Detection System for Smart Grid
Authors: Radoglou Grammatikis Panagiotis , Sarigiannidis Panagiotis , Efstathopoulos Georgios , Panaousis Emmanouil
Published: September 2020

The advent of the Smart Grid (SG) raises severe cybersecurity risks that can lead to devastating consequences. In this paper, we present a novel anomaly-based Intrusion Detection System (IDS), called ARIES (smArt gRid Intrusion dEtection System), which is capable of protecting efficiently SG communications. ARIES combines three detection layers that are devoted to recognising possible cyberattacks and anomalies against (a) network flows, (b) Modbus/Transmission Control Protocol (TCP) packets and (c) operational data. Each detection layer relies on a Machine Learning (ML) model trained using data originating from a power plant. In particular, the first layer (network flow-based detection) performs a supervised multiclass classification, recognising Denial of Service (DoS), brute force attacks, port scanning attacks and bots. The second layer (packet-based detection) detects possible anomalies related to the Modbus packets, while the third layer (operational data based detection) monitors and identifies anomalies upon operational data (i.e., time series electricity measurements). By emphasising on the third layer, the ARIES Generative Adversarial Network (ARIES GAN) with novel error minimisation functions was developed, considering mainly the reconstruction difference. Moreover, a novel reformed conditional input was suggested, consisting of random noise and the signal features at any given time instance. Based on the evaluation analysis, the proposed GAN network overcomes the efficacy of conventional ML methods in terms of Accuracy and the F1 score.
User-Experience with Haptic Feedback Technologies and Text Input in Interactive Multimedia Devices
Authors: Silva Bruno , Costelha Hugo , Bento Luis C. , Barata Marcio , Assuncao Pedro
Published: September 2020

Remote control devices are commonly used for interaction with multimedia equipment and applications (e.g., smart TVs, gaming, etc.). To improve conventional keypad-based technologies, haptic feedback and user input capabilities are being developed for enhancing the UX and providing advanced functionalities in remote control devices. Although the sensation provided by haptic feedback is similar to mechanical push buttons, the former offers much greater flexibility, due to the possibility of dynamically choosing different mechanical effects and associating different functions to each of them. However, selecting the best haptic feedback effects among the wide variety that is currently enabled by recent technologies, remains a challenge for design engineers aiming to optimise the UX. Rich interaction further requires text input capability, which greatly influences the UX. This work is a contribution towards UX evaluation of remote control devices with haptic feedback and text input. A user evaluation study of a wide variety of haptic feedback effects and text input methods is presented, considering different technologies and different number of actuators on a device. The user preferences, given by subjective evaluation scores, demonstrate that haptic feedback has undoubtedly a positive impact on the UX. Moreover, it is also shown that different levels of UX are obtained, according to the technological characteristics of the haptic actuators and how many of them are used on the device.
Understanding Data-Driven Cyber-Physical-Social System (D-CPSS) Using a 7C Framework in Social Manufacturing Context
Authors: Yin Dao , Ming Xinguo , Zhang Xianyu
Published: September 2020

The trend towards socialization, personalization and servitization in smart manufacturing has attracted the attention of researchers, practitioners and governments. Social manufacturing is a novel manufacturing paradigm responding to this trend. However, the current cyber–physical system (CPS) merges only cyber and physical space; social space is missing. A cyber–physical–social system (CPSS)-based smart manufacturing is in demand, which incorporates cyber space, physical space and social space. With the development of the Internet of Things and social networks, a large volume of data is generated. A data-driven view is necessary to link tri-space. However, there is a lack of systematical investigation on the integration of CPSS and the data-driven view in the context of social manufacturing. This article proposes a seven-layered framework for a data-driven CPSS (D-CPSS) along the data–information–knowledge–wisdom (DIKW) pyramid under a social manufacturing environment. The evolution, components, general model and framework of D-CPSS are illustrated. An illustrative example is provided to explain the proposed framework. Detailed discussion and future perspectives on implementation are also presented.
Networked Roadside Perception Units for Autonomous Driving
Authors: Tsukada Manabu , Oi Takaharu , Kitazawa Masahiro , Esaki Hiroshi
Published: September 2020

Vehicle-to-Everything (V2X) communication enhances the capability of autonomous driving through better safety, efficiency, and comfort. In particular, sensor data sharing, known as cooperative perception, is a crucial technique to accommodate vulnerable road users in a cooperative intelligent transport system (ITS). In this paper, we describe a roadside perception unit (RSPU) that combines sensors and roadside units (RSUs) for infrastructure-based cooperative perception. We propose a software called AutoC2X that we designed to realize cooperative perception for RSPUs and vehicles. We also propose the concept of networked RSPUs, which is the inter-connection of RSPUs along a road over a wired network, and helps realize broader cooperative perception. We evaluated the RSPU system and the networked RSPUs through a field test, numerical analysis, and simulation experiments. Field evaluation showed that, even in the worst case, our RSPU system can deliver messages to an autonomous vehicle within 100 ms. The simulation result shows that the proposed priority algorithm achieves a wide perception range with a high delivery ratio and low latency, especially under heavy road traffic conditions.
Deep Spectral-Spatial Features of Near Infrared Hyperspectral Images for Pixel-Wise Classification of Food Products
Authors: Zhu Hongyan , Gowen Aoife , Feng Hailin , Yu Keping , Xu Jun-Li
Published: September 2020

Hyperspectral imaging (HSI) emerges as a non-destructive and rapid analytical tool for assessing food quality, safety, and authenticity. This work aims to investigate the potential of combining the spectral and spatial features of HSI data with the aid of deep learning approach for the pixel-wise classification of food products. We applied two strategies for extracting spatial-spectral features: (1) directly applying three-dimensional convolution neural network (3-D CNN) model; (2) first performing principal component analysis (PCA) and then developing 2-D CNN model from the first few PCs. These two methods were compared in terms of efficiency and accuracy, exemplified through two case studies, i.e., classification of four sweet products and differentiation between white stripe (“myocommata”) and red muscle (“myotome”) pixels on salmon fillets. Results showed that combining spectral-spatial features significantly enhanced the overall accuracy for sweet dataset, compared to partial least square discriminant analysis (PLSDA) and support vector machine (SVM). Results also demonstrated that spectral pre-processing techniques prior to CNN model development can enhance the classification performance. This work will open the door for more research in the area of practical applications in food industry.
Antibody Modified Gold Electrode as an Impedimetric Biosensor for the Detection of Streptococcus pyogenes
Authors: Malinowska Natalia , Białobrzeska Wioleta , Łęga Tomasz , Pałka Katarzyna , Dziąbowska Karolina , Żołędowska Sabina , Czaczyk Elżbieta , Pala Katarzyna , Nidzworski Dawid
Published: September 2020

Streptococcus pyogenes is a known cause of a wide spectrum of diseases, from mild and acute to severe invasive infections. This paper concerns the development of a novel impedimetric biosensor for the detection of the mentioned human pathogen. The proposed biosensor is a gold disk electrode modified with commercially available antibodies attached to the surface of the electrode by carbodiimide chemistry. The conducted tests confirmed the specificity of the antibodies used, which was also demonstrated by the results obtained during the detection of S. pyogenes using electrochemical impedance spectroscopy. The developed sensor successfully detected the presence of S. pyogenes in the sample and the detection limit was calculated as 9.3 cfu/mL. The results obtained show a wide linear range for verified concentrations of this pathogen in a sample from 4.2 × 102 to 4.2 × 106 cfu/mL. Furthermore, the optimal experimentally determined time required to perform pathogen detection in the sample was estimated as 3 min, and the test did not lead to the degradation of the sample.
Impact of Three-Year Intermittent Preventive Treatment Using Artemisinin-Based Combination Therapies on Malaria Morbidity in Malian Schoolchildren
Authors: Maiga Hamma , Barger Breanna , Sagara Issaka , Guindo Abdoulaye , Traore Oumar , Tekete Mamadou , Dara Antoine , Traore Zoumana , Diarra Modibo , Coumare Samba , Kodio Aly , Toure Ousmane , Doumbo Ogobara , Djimde Abdoulaye
Published: September 2020

Previous studies have shown that a single season of intermittent preventive treatment in schoolchildren (IPTsc) targeting the transmission season has reduced the rates of clinical malaria, all-cause clinic visits, asymptomatic parasitemia, and anemia. Efficacy over the course of multiple years of IPTsc has been scantly investigated. Methods: An open, randomized-controlled trial among schoolchildren aged 6–13 years was conducted from September 2007 to January 2010 in Kolle, Mali. Students were included in three arms: sulphadoxine-pyrimethamine+artesunate (SP+AS), amodiaquine+artesunate (AQ+AS), and control (C). All students received two full doses, given 2 months apart, and were compared with respect to the incidence of clinical malaria, all-cause clinic visits, asymptomatic parasitemia, and anemia. Results: A total of 296 students were randomized. All-cause clinic visits were in the SP+AS versus control (29 (20.1%) vs. 68 (47.2%); 20 (21.7%) vs. 41 (44.6%); and 14 (21.2%) vs. 30 (44.6%); p < 0.02) in 2007, 2008, and 2009, respectively. The prevalence of asymptomatic parasitemia was lower in the SP+AS compared to control (38 (7.5%) vs. 143 (28.7%); and 47 (12.7%) vs. 75 (21.2%); p < 0.002) in 2007 and 2008, respectively. Hemoglobin concentration was significantly higher in children receiving SP+AS (11.96, 12.06, and 12.62 g/dL) than in control children (11.60, 11.64, and 12.15 g/dL; p < 0.001) in 2007, 2008, and 2009, respectively. No impact on clinical malaria was observed. Conclusion: IPTsc with SP+AS reduced the rates of all-cause clinic visits and anemia during a three-year implementation.
Non-equilibrium Molecular Dynamics for Calculating the Thermal Conductivity of Graphene-Coated Aluminum
Authors: TOPRAK Kasim , YILMAZ Ahmet
Published: September 2020

The number of graphene layer and length effect on the thermal conductivity of the graphene-coated aluminum is studied using non-equilibrium molecular dynamics (NEMD) simulation method. The NEMD simulation code is created and performed in the C++ computer programming language with Message Passing Interface (MPI) library. NEMD simulations are carried out for bare aluminum, graphene, single-layer graphene (SLG) - bilayer graphene (BLG) coated aluminum. Results show that the thermal conductivity increases with the length of the model. Moreover, coating one side of aluminum with graphene increases the phonon thermal conductivity 149% and 261% for SLG and BLG respectively.
Cobalt(II) Metal-organic Framework as Scintillating Material
Authors: Mbonu Idongesit Justina , Mbonu Charles Chisom
Published: September 2020

Novel cobalt(II) metal-organic framework was grown by the reaction of a methanol solution of 8-hydroxyquinoline and benzoic acid with aqueous solution of cobalt(II) chloride hexahydrate using slow solvent evaporation. The X-ray luminescence of the synthesized compound showed vibronic peaks: one with λmax at 489 nm and shoulders at 424 and 531 nm, respectively, which compare favorably with best  organic scintillators such as anthracene –447 nm and stilbene –410 nm currently in application.  The elemental analysis of the metal complex suggests a metal to ligands ratio of 1:1:1. Conductance measurement shows a nonelectrolytic nature of the synthesized compound. The SEM studies give the surface morphology of the complex. The observed emission bands with different dynamics in response to temperature change suggest that the Co-MOF exhibits scintillation properties. Electronic spectrum and magnetic moment studies were used to determine the geometry of the Co-MOF molecule. Thermal analysis data reported displayed the extent of stability of the Co-MOF compound. PXRD data revealed the nanocrystalline nature of the complex. Energy resolution peak observed at 2535 KeV, suggest the synthesized compound can be used as a scintillator.
Xây dựng Nhóm nghiên cứu trong lĩnh vực khoa học xã hội: Kinh nghiệm từ mô hình hợp tác giữa Trung tâm EdLab Asia với các nhóm nghiên cứu trong và ngoài nước
Authors: Hiep Pham Hung , Hoang Anh-Duc
Published: September 2020

Xây dựng nhóm nghiên cứu trong các trường đại học và tổ chức khoa học – công nghệ là một chủ đề được quan tâm đặc biệt trong thời gian gần đây. Trong bài viết này, chúng tôi trình bày kinh nghiệm xây dựng nhóm nghiên cứu thuộc lĩnh vực khoa khoa học giáo dục tại Trung tâm Nghiên cứu và Phát triển Giáo dục EdLab Asia (gọi tắt là Trung tâm EdLab Asia), là một đơn vị trẻ tuổi với 1 năm thành lập và đã có một số kết quả bước đầu với 14 công trình được công bố trên các Tạp chí thuộc danh mục Clarivate WOS và Scopus trong khoảng thời gian từ 9/2019-9/2020. Bài viết trình bày mục tiêu, chiến lược, cơ chế và nguyên tắc hoạt động của EdLab Asia. Các hàm ý chính sách dành cho các trường đại học và tổ chức khoa học công nghệ trong khoa học giáo dục nói riêng và khoa học xã hội nói chung sẽ được trình bày tại phần cuối của bài.
Impact of the COVID-19 Crisis on Science Teaching and Facilitation of Practical Activities in Irish Schools
Authors: chadwick ruth , McLoughlin Eilish
Published: September 2020

This research explored the impact of the COVID-19 crisis school closures on teaching and learning of science, with a focus on practical activities. In Ireland, practical activities and investigations are a curricular requirement. Findings from a survey carried out with primary and secondary teachers indicated the negative impact of the school closures on science learning and decreased facilitation of practical activities. Teachers reported a variety of barriers to student access and engagement, including lack of resources and technology in the home. This study highlights the risk that the COVID-19 school closures may increase pre-existing inequalities in science learning in Ireland.
TECNOLOGIAS EDUCATIVAS FACILITADORAS NA PROMOÇÃO DA SAÚDE PROJETO DE EXTENSÃO "BATE PAPO: SAÚDE NA ESCOLA": RELATO DE EXPERIÊNCIA
Authors: Pintor de Assis Correia Jásny , Vieira Lima Guilherme , Vinícius de Souza José , Souza Alixandre Ruan , Andreza da Silva Ferreira Marília , Lourenço de Oliveira Flávio
Published: September 2020

INTRODUÇÃO: o ambiente escolar pode ser utilizado/caracterizado como um eficiente meio para viabilizar ações que visem promoção da saúde, oportunizando interações que facilitam o diagnóstico e a prevenção de doenças anteriormente à adoção de comportamentos de risco. Para tanto, o uso tecnologias educacionais surge como uma importante ferramenta na construção do conhecimento, sendo capaz de consolidar também, o processo de ensino e aprendizagem. OBJETIVOS: relatar a experiência do uso de métodos ativos do aprendizado na execução de ações educativas em saúde, relacionadas a temas de grande relevância na atualidade, em uma escola da Rede Estadual de Ensino pelo projeto "Bate Papo: Saúde na Escola". MÉTODOS: trata-se de um estudo descritivo, do tipo relato de experiência, com base no Projeto de Extensão "Bate Papo: Saúde na Escola”. As ações foram respaldadas na realização de rodas de conversa, utilização de dispositivos para aplicação de jogos, além de oficinas práticas fundamentadas na demonstração de exames e métodos contraceptivos. Foram abordadas algumas Infecções Sexualmente Transmissíveis (ISTs), arboviroses e doenças fúngicas. As atividades foram desenvolvidas, sob a supervisão do Coordenador e da equipe de Orientadores, por alunos de Graduação dos cursos de Enfermagem e Medicina, da Universidade Federal de Campina Grande, Campus Cajazeiras/PB, na Escola Estadual Professor Manoel Mangueira Lima, ligada à 9ª Gerência Regional de Ensino, desta cidade, beneficiando, aproximadamente, 150 alunos. RESULTADOS: a proposta superou as expectativas em função da receptividade do público alvo às metodologias alternativas de ensino e aprendizagem, bem como a construção conjunta de saberes. Foi oportunizado aos profissionais de saúde, em formação, o contato com a comunidade, para a troca de experiências e conhecimento de sua realidade e seus anseios, que, de forma recíproca, recebeu dos extensionistas, intervenções facilitadoras à promoção da saúde. CONCLUSÃO: a utilização de metodologias alternativas, pelo projeto, mostrou-se positiva, por despertar o interesse e a motivação no aprendizado das temáticas, colaborando na construção do conhecimento do público-alvo. Ressalta-se a carência de ações promotoras de saúde na educação da rede pública de ensino e de estratégias que visem a integração familiar para discussão de temas importantes na saúde pública.

Palavras chave: Educação em Saúde, Tecnologia Educacional, Assistência à Saúde.
Building Bonds, Healing Youth: Prioritizing Youth Critical Consciousness Development in CBPR
Authors: Woods-Jaeger Briana , O'Connor Paige , Miller Teesha , Wade Chakilah , Price D'Marko , Boykin Briana , Christensen Kelsey , Berkley-Patton Jannette
Published: September 2020

Community violence continues to be a major national public health issue that disproportionately impacts African American youth. Community Based Participatory Research (CBPR) approaches have been recommended to address youth violence and provide an opportunity to partner in research with those most impacted to develop new strategies. In this brief report we describe specific capacity building efforts in our CBPR project, Building Bonds, Healing Youth, which aims to develop and test a community-level intervention to promote resilience among African American youth exposed to community violence. We specifically describe our capacity building efforts that centered around developing youth critical consciousness and highlight specific methods that we employed. Reflections from our youth partners highlight the potential impact of incorporating youth critical consciousness development into capacity building efforts with youth partners. This brief report supports incorporating critical consciousness in CBPR with youth to promote mutual benefit as youth contribute their lived experiences, expertise, and commitment to improving research addressing youth health and well-being.
Historia philosiphiae hispanae (1848) de José Fernández Cuevas: la primera historia integral de la filosofía española
Authors: Arroyo Serrano Santiago
Published: September 2020

El presente trabajo pretende dar a conocer la segunda parte de la obra escrita en latín por el filósofo escolástico español José Fernández Cuevas, considerada por los investigadores como la primera obra de historia de la filosofía en España. En este artículo presentamos algunos textos traducidos con una breve introducción a los valores pioneros de la obra Historia philosophiae hispanae.
Determinan pendidikan dan Pengetahuan Terhadap Pemberian Imunisasi Pada Bayi di Wilayah Kerja Puskesmas Kampeonaho Kota Bau-Bau
Authors: Meilani Ni’ma , Darmawan Agus , Wahyuddin Wahyuddin , Dahmar Dahmar , Megawati Megawati , Kusnan Adius
Published: September 2020

Cakupan imunisasi di wilayah kerja Puskesmas Kampeonaho pada tahun 2018 dari bulan Januari sampai bulan Desember sebanyak 62,1%. Masih banyak para ibu yang tidak membawa anaknya untuk di imunisasi.Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang memengaruhi pemberian imunisasi pada bayi di wilayah kerja Puskesmas Kampeonaho Kota Bau-bau. Jenis penelitian yang digunakan adalah kuantitatif dengan pendekatan cross sectional. Jumlah populasi sebanyak 83 orang. Sampel dalam penelitian ini diambil dengan menggunakan teknik total sampling. Pengumpulan data melalui data primer dan data sekunder. Pengolahan dan analisis data dengan menggunakan program SPSS dengan analisis data univariat dan bivariat (chi square). Hasil penelitian menunjukkan bahwa ada antara pendidikan dengan nilai signifikasinya 0,041<0,05, pengetahuan dengan nilai signifikasinya 0,050 < 0,05 terhadap pemberian imunisasi pada bayi di wilayah kerja Puskesmas Kampeonaho Kota Bau-bau. Kesimpulan dari penelitian ini yaitu ada hubungan status pendidikan dan pengetahuan terhadap pemberian imunisasi pada bayi di wilayah kerja Puskesmas Kampeonaho Kota Bau-bau.
THE INFLUENCE OF USING SMARTPHONE TO THE DEVELOPMENT OF PRE SCHOOL AGED CHILDREN
Authors: Khodijah Upus Piatun , Mega Mega , Ulfah Erliana
Published: September 2020

One of the development information technology and communication is the  development of telecomunication technology of Smartphone. The smartphone has the ability of functions and uses  similarly like computer. The impacts of using Smartphone to childhood  cause worriness because they are unstable enough, they have very high curiousity and influence to the effect of increasing their consumtive character. The aims of this research were to analyze the influence of using smartphone to the development of  pre school aged children at Kindergarten School and Early Childhood Education of Permata Hati Cijelag, Tomo Village, Subdistrict Tomo, Sumedang Regency. This research used quantitative method. Sampling taking in this research used nonprobability sampling by using  total sampling, the respondents in this research were pre school aged children in Kindergarten School and Early  Childhood Education Permata Hati Cijelag, Tomo Village, Subdistrict Tomo, Sumedang Regency in 2019. The research subjects  were pre school aged children in Kindergarten School and Early  Childhood Education Permata Hati Cijelag, Tomo Village, Subdistrict Tomo, Sumedang Regency as many as 30 children. Statististicstesting before data analysis gained made a normality test by Saphiro Wilk, then data distributed normally thus the next test did  independent t test  with significance p<0,05. The research result showed that there are influences of using Smartphone to the development of pre school aged children with significant score (r) = 0,02 < 0,05. The research result showed that there are influences of using Smartphone to the development of pre school aged children.
Simulasi Monte Carlo dalam Prediksi Jumlah Penumpang Angkutan Massal Bus Rapid Transit Kota Padang
Authors: Alfikrizal Khaliq , Defit Sarjon , Yunus Yuhandri
Published: September 2020

Bus Rapid Transit is a system of bus facilities, services and comfort which is used to increase speed and reliability and is integrated with a strong transit identity through high quality services. Trans Padang is a land transportation based on Bus Rapid Transit in Padang City which is managed by the Transportation Agency which started operating in January 2014 with a total bus fleet of 10 units on the Lubuk Buaya-Pasar Raya Padang route. Currently it has 2 corridors operating out of 6 corridors designed. This study aims to predict the number of Bus Rapid Transit passengers in Padang City and determine the level of accuracy of simulation data with real data using the Monte Carlo method. The data used to predict the number of passengers is data on the number of passengers from January 2017 to December 2019. From the simulations carried out, simulated accuracy is obtained for predicting the number of passengers with an average accuracy of above 80%. Based on a fairly high level of accuracy, the application of the Monte Carlo method to predict the number of Bus Rapid Transit passengers in Padang City is considered to be able to predict the number of passengers in the following year.
Simple Additive Weighting dalam Penyaluran Dana Bantuan Sekolah Dasar
Authors: Afifah Trista Ayunda  , Defit Sarjon , Nurcahyo Gunadi Widi
Published: September 2020

Dana bantuan sekolah adalah penyaluran dana pendidikan bagi sekolah dasar yang bersumber dari Bos Kinerja. Bos Kinerja atau bantuan operasional sekolah di peruntukan bagi sekolah yang dinilai memilki kinerja yang baik. Kendala yang sering timbul yaitu penyaluran dana bantuan sekolah yang tidak tepat sasaran, hal tersebut diakibatkan tidak terdapatnya metode dalam penyaluran dana tersebut, sehingga berdampak kepada kinerja satuan pendidikan sekolah. Sistem pendukung keputusan menggunakan metode Simple Additive Weighting (SAW) digunakan untuk mendorong mutu layanan pendidikan bagi sekolah dasar yang dinilai memiliki kinerja baik dalam satuan pendidikan. Sistem tersebut berfungsi mempermudah dalam pengambilan maupun pendukung keputusan dalam penyaluran dana bantuan sekolah dasar. Pada penelitian ini diperoleh hasil akhir akurasi 100 % dengan demikian pengadopsian metode Simple Additive Weighting membantu dalam pengambilan keputusan yang tepat sasaran dalam penyaluran dana bantuan sekolah dasar.
A Framework for Knowledge-Based Enterprise Financial Support in Iran
Authors: Mojtaba Valibeigi  , Ahmad Mohammadi  , Mojgan Valibeigi  , Abdolhossein Zameni
Published: September 2020

In line with other Iranian protection laws for reducing unemployment and increasing the economic growth, knowledge-based enterprises' protection law faces to serious challenges that causes this law will not reach to its aim. The purpose of the study is to present a framework for financial support of Iranian knowledge-based enterprises based on British Investment Bank. This bank is a conjugation of intergovernmental and financial banking. This type of banking is not a competitor to other financial banks. The main tendency of such a bank is to support small and medium-sized knowledge-based enterprises which are in the early stages of their growth and are not attractive enough for investors. In a supportive environment with the right framework for funding, knowledge-based enterprises can both thrive and grow, and stimulate employment and economic growth.
Time Series Features and Machine Learning Forecasts
Authors: Claveria Oscar , Monte Enric , Torra Salvador
Published: September 2020

In this study we combine the results of two independent analyses to position Spanish regions according to both the characteristics of the time series of international tourist arrivals and the accuracy of predictions of arrivals at the regional level. We apply a seasonal trend decomposition procedure based on nonparametric regression to isolate the different components of the series and calculate the main time series features. Predictions are generated with several machine learning models in a recursive multistep-ahead forecasting experiment. Finally, we summarize all the information from the two previous experiments using categorical principal component analysis. By overlapping the distribution of the regions and the component loadings of each variable along both dimensions, we observe that entropy and dispersion show an inverse relation with forecast accuracy, but the interactions between the rest of the features and accuracy are heavily dependent on the forecast horizon. On this evidence, we conclude that in order to increase forecast accuracy of tourist arrivals at the regional level, model selection should be region specific and based on the forecast horizon.
Ginkgetin Inhibits Growth and Invasion of Endometrial Carcinoma by Disruption of Janus Kinase 1/Signal Transducers and Activators of Transcription 3 and Phosphoinositide-3-Kinase/ Protein Kinase B Pathways
Authors: Pan Shishi , Xie Fengfeng , Chen Wenming , Zhai Qi , Zhu Lili
Published: September 2020

Ginkgetin, a bioflavonoid derived from Ginkgo biloba leaves has been shown to promote tumor cell apoptosis and suppress cell growth in a variety of tumors. This study has examined the role and mechanism of ginkgetin on the tumorigenesis of endometrial carcinoma. Results of the studies show that ginkgetin treatment led to a dose-dependent decrease in cell viability, enhanced expression of cleaved caspase-3 protein, and reduced expression of Bcl-2 protein. In addition, cell migration and invasion of HEC1B and Ishikawa cells were repressed by ginkgetin treatment. Levels of phosphoprotein kinase B, Janus kinase 1, and signal transducers and activators of transcription 3 were decreased in HEC1B and Ishikawa cells by ginkgetin treatment. In conclusion, ginkgetin presents with potential for further investigations into its possible role in management of endometrial carcinoma.
Biologinė terapija benralizumabu gydant sunkią eozinofilinę astmą. Privalumai ir kylantys klausimai
Authors: Kalinauskaitė-Žukauskė Virginija
Published: September 2020

Biologinės terapijos sukūrimas yra proveržis eozinofilinės astmos gydyme. Slopinant interleukino-5 signalinį kelią, pvz., benralizumabu, veiksmingaimažinamas eozinofilinis uždegimas, retinami astmos paūmėjimai, pavyksta pasiekti geresnės astmos simptomų kontrolės, sumažinti geriamųjų gliukokortikoidų dozes arba juos visiškai nutraukti. Šis gydymas pasižymi ir geru saugumo profiliu. Tačiau kyla klausimų: ar sunaikinus eozinofilus ir pagerinus astmos kontrolę, nesumažinamas priešvirusinis eozinofilų poveikis? Ar neskatinama tumorogenezė? Atlikta nemažai tyrimų, kuriuose aktyviai diskutuojama šiaisklausimais. Sergant eozinofiline astma, eozinofilai yra kitokie nei sveikų asmenų, todėl, juos sunaikinus, nepakanka pagrįstumo apie galimą žalą žmogaus sveikatai.
Novel approach to chronic cough
Authors: Kondratavičienė Laima , Biekšienė Kristina , Miliauskas Skaidrius
Published: September 2020

Cough is the most common symptom for which people seek medical advice. A multitude of reasons can cause it. In clinical practice, a new term “Cough hypersensitivity syndrome“ was proposed, which defines unaccountable reasons forcough and different groups of patients with chronic cough. Adenosine triphosphate (ATP) as a driver of chronic cough is the most important target in nowadays clinical trials. Extracellular ATP activates P2X purinoreceptor 3 (P2X3) receptor channels, which are expressed in sensory neurons. New treatment methods that block P2X3 receptors are being developed.
Chinese experience in implementing renewable energy sources as a possible scenario for the Krasnoyarsk Territory
Authors: Nikonorov Sergey , Papenov Konstantin , Sergeyev Denis
Published: September 2020

Renewable energy is a rapidly developing area of the modern economy. As many experts forecast, global electricity consumption will double by 2050, while the share of renewable sources in energy generation will be 50%. For most states, the main incentives for the development of renewable energy are the ability to eliminate the consumption of fossil fuels and reduce the level of emissions of pollutants, while ensuring sustainable development of the country. At the same time, Russia, which has significant reserves of natural resources, is in no hurry to switch to the use of energy from renewable sources since it is believed that the country’s subsoil can provide it with cheap energy resources for many generations to come. Therefore, introduction of renewable energy sources that are unable to compete with traditional energy without a developed energy infrastructure and established production is impractical. In our study we try to evaluate the efficiency of the introduction of renewable energy sources in the Krasnoyarsk Territory of Russia using the example of the Chinese experience.
EPIDEMIOLOGIA: CORONAVÍRUS (COVID-19) E RECOMENDAÇÕES DA PRÁTICA DE ATIVIDADE FÍSICA E EXERCÍCIO FÍSICO
Authors: Hartmann Cassio , César Dias Lopes Gabriel , Da Silva Ferreira Vieira Fábio , V Samuel Bensson
Published: September 2020

O novo Coronavírus foi nomeado como SARS-CoV-2. que produz a doença classificada como COVID-19, sendo agente causador de  ma série de casos de pneumonia em todos os cinco continentes, tornando-se uma pandemia mundial e a mesma, iniciou-se na  idade de Wuhan (China). O presente estudo teve como objetivo, fazer saber, sobre o conhecimento da epidemiologia e etiologia do Coronavírus (COVID-19), como ocorre a infecção, seus sinais, sintomas, diagnóstico e as recomendações para a prática do exercício e  a atividade física. Essa pesquisa é do tipo documental. Seguir as orientações da Organização Mundial de Saúde (OMS) e dos  emais órgãos e secretárias de saúde significa proteger-se e não ser infectado pelo Coronavírus e pode-se concluir, que o Governo  ederal, através do Ministério da Saúde, vem agregar o profissional de Educação Física, em equipe multidisciplinar do Sistema Único  e Saúde - SUS. Disposto sobre a Ação Estratégica “O Brasil Conta Comigo – Profissionais da Saúde”, voltado para à capacitação e ao  adastramento de profissionais da área de saúde, sendo uma das áreas os professores de Educação Física do território nacional e  stando os mesmos com o registro no Conselho Regional de Educação Física - CREF, para o enfrentamento à pandemia do Coronavírus (COVID-19), sendo de responsabilidade do Conselho Federal de Educação Física – CONFEF, confirmar o profissionais  abilitados, junto ao Ministério da Saúde.
Standardised spider (Arachnida, Araneae) inventory of Kilpisjärvi, Finland
Authors: Kiljunen Niina , Pajunen Timo , Fukushima Caroline , Soukainen Arttu , Kuurne Jaakko , Korhonen Tuuli , Saarinen Joni , Falck Ilari , Laine Erkka , Mammola Stefano , Urbano Fernando , Macías-Hernández Nuria , Cardoso Pedro
Published: September 2020

A spider taxonomy and ecology field course was organised in Kilpisjärvi Biological Station, northern Finland, in July 2019. During the course, four 50 × 50 m plots in mountain birch forest habitat were sampled following a standardised protocol. In addition to teaching and learning about spider identification, behaviour, ecology and sampling, the main aim of the course was to collect comparable data from the Kilpisjärvi area as part of a global project, with the purpose of uncovering global spider diversity patterns.

A total of 2613 spiders were collected, of which 892 (34%) were adults. Due to uncertainty of juvenile identification, only adults are included in the data presented in this paper. The observed adult spiders belong to 51 species, 40 genera and 11 families, of which the Linyphiidae were the most rich and abundant with 28 (55%) species and 461 (52%) individuals. Lycosidae had six species and 286 individuals, Gnaphosidae five species and 19 individuals, Thomisidae four species and 24 individuals, Theridiidae two species and 23 individuals. All other six families had one species and less than 40 individuals. The most abundant species were the linyphiid Agnyphantes expunctus (204) and the lycosids Pardosa eiseni (164) and Pardosa hyperborea (107).
Comparative cytogenetic of six species of Amazonian Peacock bass (Cichla, Cichlinae): intrachromosomal variations and genetic introgression among sympatric species
Authors: Quadros Janice , Ferreira Alex M. V. , Viana Patrik F. , Marajó Leandro , Oliveira Ezequiel , Ferreira Efrem , Feldberg Eliana
Published: September 2020

Cytogenetic data for the genus Cichla Bloch et Schneider, 1801 are still very limited, with only four karyotype descriptions to date. The sum of the available cytogenetic information for Cichla species, points to a maintenance of the diploid number of 48 acrocentric chromosomes, considered a typical ancestral feature in cichlids. In the current study, we performed molecular and classical cytogenetic analyses of the karyotype organization of six species of Cichla, the earliest-diverging genus of Neotropical cichlids. We cytogenetically analysed Cichla kelberi Kullander et Ferreira, 2006, Cichla monoculus Agassiz, 1831, Cichla piquiti Kullander et Ferreira, 2006, Cichla temensis Humboldt, 1821, Cichla vazzoleri Kullander et Ferreira, 2006 and Cichla pinima Kullander et Ferreira, 2006, including three individuals that showed mixed morphological characteristics, likely from different species, suggesting they were hybrid individuals. All individuals analysed showed 2n = 48 acrocentric chromosomes, with centromeric heterochromatic blocks on all chromosomes and a terminal heterochromatic region on the q arm of the 2nd pair. Mapping 18S rDNA gave hybridization signals, correlated with the nucleolus organizer regions, on the 2nd pair for all analyzed individuals. However, we found distinct patterns for 5S rDNA: interstitially at the proximal position on 6th pair of four species (C. kelberi, C. pinima, C. piquiti and C. vazzoleri), and on the distal of the 4th pair in two (C. monoculus and C. temensis). Accordingly, we present here new data for the genus and discuss the evolutionary trends in the karyotype of this group of fish. In addition, we provide data that supports the occurrence of hybrid individuals in the Uatumã River region, mainly based on 5S rDNA mapping.
L’imagination de la fable. Les Fables choisies de La Fontaine mises en vignettes par François Chauveau
Authors: Escola Marc
Published: September 2020

Chacune des vignettes signées par Fr. Chauveau pour l’édition originale des Fables de La Fontaine ne témoigne pas seulement d’une lecture particulièrement attentive de l’apologue qu’elle illustre : il faut reconnaître à l’illustrateur une audace dans l’invention de détails logiquement déduits de la lettre du texte qui n’a rien à envier à la liberté dont témoigne La Fontaine à l’égard de ses devanciers. On peut le dire autrement : Chauveau a su regarder les fables de La Fontaine de l’œil dont celui-ci lisait les apologues ésopiques, bien décidé à les affabuler autrement pour y révéler tel ou tel motif resté inaperçu et élaborer par là quelque signification inattendue. Fables de La Fontaine mises en vignettes par François Chauveau donc, au sein du recueil des Fables d’Ésope mises en vers par M. de La Fontaine .