bluuebunny/crossref_metadata_2025 huggingface dataset:
Network Embedding the Protein–Protein Interaction Network for Human Essential Genes Identification
Authors: Dai Wei , Chang Qi , Peng Wei , Zhong Jiancheng , Li Yongjiang
Published: January 2020

Essential genes are a group of genes that are indispensable for cell survival and cell fertility. Studying human essential genes helps scientists reveal the underlying biological mechanisms of a human cell but also guides disease treatment. Recently, the publication of human essential gene data makes it possible for researchers to train a machine-learning classifier by using some features of the known human essential genes and to use the classifier to predict new human essential genes. Previous studies have found that the essentiality of genes closely relates to their properties in the protein–protein interaction (PPI) network. In this work, we propose a novel supervised method to predict human essential genes by network embedding the PPI network. Our approach implements a bias random walk on the network to get the node network context. Then, the node pairs are input into an artificial neural network to learn their representation vectors that maximally preserves network structure and the properties of the nodes in the network. Finally, the features are put into an SVM classifier to predict human essential genes. The prediction results on two human PPI networks show that our method achieves better performance than those that refer to either genes’ sequence information or genes’ centrality properties in the network as input features. Moreover, it also outperforms the methods that represent the PPI network by other previous approaches.
Particle Size Distribution of Natural Clayey Soils: A Discussion on the Use of Laser Diffraction Analysis (LDA)
Authors: Gorączko Aleksandra , Topoliński Szymon
Published: January 2020

Particle size distribution is one of the most significant factors determining physical soil properties. Laser diffraction analysis (LDA) is an alternative method to the traditional hydrometric methods (HM) used to determine particle size distribution in soils. However, significant differences in fraction content are found in relation to the applied methods of a particle size test. Above all, measurements performed by LDA for clayey soils usually produce different results to those based on Stokes’ equation. Methodical problems, such as an appropriate method of dispersing the sample and the selection of LDA calculation theory, also play a significant role in fine soils. This paper contains the results of analyses of Neogene clays from Poland, which are characterized by differentiation with regard to the content of clay fraction particles. In this article, the validity of using laser diffraction analysis (LDA) for the identification and characterization of clayey sediments with common genesis is assessed. The possibility of finding reliable pedotransfer functions to the convert LDA results to a hydrometric analysis is discussed.
Influence of Social Safety Capital on Safety Citizenship Behavior: The Mediation of Autonomous Safety Motivation
Authors: Zhang Junjie , Zhai Huaiyuan , Meng Xiangcheng , Wang Wanxue , Zhou Lei
Published: January 2020

In recent years, the safety issue of construction workers has become a research hotspot, and many researchers have achieved results in the impact of safety behavior regarding China’s construction industry. However, the existing research about the driving factors of safety citizenship behavior is insufficient. To fill this gap, this paper explores the driving factor of safety citizenship behavior from the perspective of social capital theory. A cross-sectional questionnaire survey, involving 311 Chinese construction workers, was conducted to verify the influence of Social Safety Capital on Safety Citizenship Behavior. The results showed that safety citizenship behavior made by workers was significantly related to social safety capital. Autonomous safety motivation mediated the relationships between social safety capital and safety citizenship behavior. Further, this research supports the differences between social safety capital and autonomous safety motivation. Specifically, the paper found that social safety capital had the largest regression coefficient for participation of suggestion-making, and autonomous safety motivation had the largest regression coefficient for the relationship between superior and subordinate by multiple regression analysis.
Adoption of Precision Farming Tools: The Case of Italian Farmers
Authors: Vecchio Yari , Agnusdei Giulio Paolo , Miglietta Pier Paolo , Capitanio Fabian
Published: January 2020

The process of adopting innovation, especially with regard to precision farming (PF), is inherently complex and social, and influenced by producers, change agents, social norms and organizational pressure. An empirical analysis was conducted among Italian farmers to measure the drivers and clarify “bottlenecks” in the adoption of agricultural innovation. The purpose of this study was to analyze the socio-structural and complexity factors that affect the probability to adopt innovations and the determinants that drive an individual’s decisions. Preliminary results found high levels of adoption among younger farmers, those that had a high level of education, those with high intensity of information, with large farm sizes, and high labor intensity. A logit model was used to understand the role played by labor intensity and perceived in the adoption process. In light of the Common Agricultural Policy Reform post 2020, the findings suggest relevant policy implications, such as the need to increase awareness of PF tools and foster dissemination of information aimed at reducing the degree of perceived complexity.
Sex- and Gender-Based Analysis in Cannabis Treatment Outcomes: A Systematic Review
Authors: Brabete Andreea C. , Greaves Lorraine , Hemsing Natalie , Stinson Julie
Published: January 2020

There is evidence that sex- and gender-related factors are involved in cannabis patterns of use, health effects and biological mechanisms. Women and men report different cannabis use disorder (CUD) symptoms, with women reporting worse withdrawal symptoms than men. The objective of this systematic review was to examine the effectiveness of cannabis pharmacological interventions for women and men and the uptake of sex- and gender-based analysis in the included studies. Two reviewers performed the full-paper screening, and data was extracted by one researcher. The search yielded 6098 unique records—of which, 68 were full-paper screened. Four articles met the eligibility criteria for inclusion. From the randomized clinical studies of pharmacological interventions, few studies report sex-disaggregated outcomes for women and men. Despite emergent evidence showing the influence of sex and gender factors in cannabis research, sex-disaggregated outcomes in pharmacological interventions is lacking. Sex- and gender-based analysis is incipient in the included articles. Future research should explore more comprehensive inclusion of sex- and gender-related aspects in pharmacological treatments for CUD.
Factors Influencing the Quality of Life of Korean Elderly Women by Economic Status
Authors: Kwon Myoungjin , Kim Sun Ae , So. Wi-Young
Published: January 2020

Purpose: This study aimed to determine whether there are differences in the factors affecting the quality of life (QOL) of elderly women in South Korea according to their perceived economic status. Methods: Data were extracted from the Seventh Korea National Health and Nutrition Examination Survey conducted in 2016. The participants were 879 women over the age of 65 years, who were divided into three groups: high, medium, and low based on their perceived economic status. The study variables were classified into three categories: general characteristics, physical factors, and psychological factors. General characteristics included age, education level, employment, activity restriction, frequency of breakfast/week, frequency of lunch/week, and frequency of dinner/week. Physical factors included disease status, weight change, consumption of alcohol, number of days of walking per week, duration of walking at a time, body mass index (BMI), and discomfort due to changes in hearing. Psychological factors included stress, subjective body awareness, subjective health status, depressive symptoms, and QOL. Complex sample crosstabs and chi-square tests were conducted, and regression was performed to examine the association between the variables by economic status. Results: The factors that influenced the QOL of elderly women with low economic status were arthritis, alcohol consumption, subjective health status, and depressive symptoms, with an explanatory power of 54.3% (F = 14.94, p < 0.001). The factors that influenced the QOL of the medium economic status group were activity restriction, frequency of dinner/week, arthritis, number of days of walking per week, BMI, stress, subjective health status, and depressive symptoms, with an explanatory power of 48.6% (F = 9.82, p < 0.001). For the high economic status group, influential factors were age, restricted activity, arthritis, number of days of walking per week, stress, and depressive symptoms with an explanatory power of 49.0% (F = 69.76, p < 0.001). Conclusions: This study identified different factors that contributed to the QOL of elderly women by economic status.
‘We Are Drinking Diseases’: Perception of Water Insecurity and Emotional Distress in Urban Slums in Accra, Ghana
Authors: Kangmennaang Joseph , Bisung Elijah , Elliott Susan J.
Published: January 2020

Water security is critical to the health and well-being of people around the world, especially among populations experiencing water stresses and rapid urbanization in low- to middle-income countries (LMICs). Recent research suggests water insecurity is associated with negative mental health outcomes. Despite global improvement in access to safe water across the world, the World Health Organization (WHO) reports that access to safe water in urban areas has not changed significantly or has stagnated in certain countries. In most African cities, entrepreneurial water vendors have stepped up to fill supply gaps in the formal delivery system by selling vended water. As part of a larger research program that aims to assess and analyze public perceptions around vended water, this paper explores the links connecting water insecurity and emotional distress among urban slum dwellers who mostly use vended water in Accra, Ghana. We used a parallel mixed-methods approach. Our quantitative results show that water-insecure households (OR = 2.23, p = 0.01) were more likely to report emotional distresses compared to water-secure households. However, households with improved sanitation (OR = 0.28, p = 0.01) and those willing to participate for improved water and sanitation (OR = 0.28, p = 0.01) were less likely to report emotional distress. Our qualitative results offered support for the quantitative results, as participants not only hold various perceptions regarding the safety and quality of vended water but expressed emotional distresses such as fear of contamination, discomfort, worry over arbitrary change in prices, and anxiety. The implications of the results for policy and practice, specifically to ensuring access to safe water, are discussed.
Transparency of Financial Reporting on Greenhouse Gas Emission Allowances: The Influence of Regulation
Authors: Milanés Montero Patricia , Pérez Calderón Esteban , Lourenço Dias Ana Isabel
Published: January 2020

This study focuses on the transparency of financial reporting on emission allowances (EA) and greenhouse gas (GHG) emissions within the European Union Emissions Trading Scheme (EU ETS). In particular, the different accounting treatments adopted by standard setters and professionals were analyzed to evaluate the influence of regulation in the transparency of financial reporting on EA and GHG emissions. Based on a sample of 85 companies registered with the Portuguese, Spanish, and French National Plans of Allocation (NPAs), data collected from the annual reports were analyzed for the 2008–2014 period. The results were obtained based on descriptive, logistic regressions and panel data statistical techniques, and they show that better levels of transparency of financial reporting on EA and GHG emissions are conditioned by a variety of accounting policies, which compromises the comparability of the financial information. The adoption of the International Accounting Standards Board (IASB) standards set lead to a greater dispersion in the choice of the accounting approach and a higher probability of not disclosing any information, as well as adopting off-balance sheet policies. Therefore, the regulatory factor is a determinant of the level of transparency of financial reporting on EA and GHG emissions, contributing to reduce strategies of omission.
Effects of a Bout of Intense Exercise on Some Executive Functions
Authors: Coco Marinella , Buscemi Andrea , Guerrera Claudia Savia , Di Corrado Donatella , Cavallari Paolo , Zappalà Agata , Di Nuovo Santo , Parenti Rosalba , Maci Tiziana , Razza Grazia , Petralia Maria Cristina , Perciavalle Vincenzo , Perciavalle Valentina
Published: January 2020

The present study examined the effects of an exhaustive exercise on executive functions by using the Stroop Color Word Test (SCWT), Trail Making Test (TMT), A and B, and simple Reaction Time (RT). Thirty adults agreed to participate; 15 participants had a mean age of 24.7 years ± 3.2 Standard Deviation (SD, Standard Deviation) (group YOUNG), while the remaining 15 had a mean age of 58.9 years ± 2.6 SD (group OLD). Each subject performed the cognitive tasks at rest and blood lactate was measured (pre); each subject executed the acute exhaustive exercise and, immediately after the conclusion, executed the cognitive tasks and blood lactate was again measured (end). Cognitive tests were repeated and blood lactate measured 15 min after its conclusion of the exhaustive exercise (post). We observed: (1) a significant positive correlation between blood lactate levels and RT levels; (2) a significant negative relationship between levels of blood lactate and the SCWT mean score; (3) no significant correlation between blood lactate levels and TMT scores (time and errors), both A and B; (4) variations in blood lactate levels, due to exhaustive exercise, and parallel deterioration in the execution of RT and SCWT are significantly more pronounced in the group YOUNG than in the group OLD. The present study supports the possibility that high levels of blood lactate induced by an exhaustive exercise could adversely affect the executive functions pertaining to the prefrontal cortex.
BMAL1 Modulates Epidermal Healing in a Process Involving the Antioxidative Defense Mechanism
Authors: Silveira Ericka J. D. , Nascimento Filho Carlos H. V. , Yujra Veronica Q. , Webber Liana P. , Castilho Rogerio M. , Squarize Cristiane H.
Published: January 2020

The circadian rhythm regulates the physiology and behavior of living organisms in a time-dependent manner. Clock genes have distinct roles including the control over gene expression mediated by the transcriptional activators CLOCK and BMAL1, and the suppression of gene expression mediated by the transcriptional repressors PER1/2 and CRY1/2. The balance between gene expression and repression is key to the maintenance of tissue homeostasis that is disrupted in the event of an injury. In the skin, a compromised epithelial barrier triggers a cascade of events that culminate in the mobilization of epithelial cells and stem cells. Recruited epithelial cells migrate towards the wound and reestablish the protective epithelial layer of the skin. Although we have recently demonstrated the involvement of BMAL and the PI3K signaling in wound healing, the role of the circadian clock genes in tissue repair remains poorly understood. Here, we sought to understand the role of BMAL1 on skin healing in response to injury. We found that genetic depletion of BMAL1 resulted in delayed healing of the skin as compared to wild-type control mice. Furthermore, we found that loss of Bmal1 was associated with the accumulation of Reactive Oxygen Species Modulator 1 (ROMO1), a protein responsible for inducing the production of intracellular reactive oxygen species (ROS). The slow healing was associated with ROS and superoxide dismutase (SOD) production, and pharmacological inhibition of the oxidative stress signaling (ROS/SOD) led to cellular proliferation, upregulation of Sirtuin 1 (SIRT1), and rescued the skin healing phenotype of Bmal1−/− mice. Overall, our study points to BMAL1 as a key player in tissue regeneration and as a critical regulator of ROMO1 and oxidative stress in the skin.
Effect of Pepper-Containing Diets on the Diversity and Composition of Gut Microbiome of Drosophila melanogaster
Authors: Garcia-Lozano Marleny , Haynes Joshua , Lopez-Ortiz Carlos , Natarajan Purushothaman , Peña-Garcia Yadira , Nimmakayala Padma , Stommel John , Alaparthi Suresh B. , Sirbu Cristian , Balagurusamy Nagamani , Reddy Umesh K.
Published: January 2020

One of the greatest impacts on the gastrointestinal microbiome is diet because the host and microbiome share the same food source. In addition, the effect of diet can diverge depending on the host genotype. Diets supplemented with phytochemicals found in peppers might cause shifts in the microbiome. Thus, understanding how these interactions occur can reveal potential health implications associated with such changes. This study aims to explore the gut microbiome of different Drosophila genetic backgrounds and the effects of dietary pepper treatments on its composition and structure. We analyzed the gut microbiomes of three Drosophila melanogaster genetic backgrounds (Canton-S, Oregon-RC, and Berlin-K) reared on control and pepper-containing diets (bell, serrano, and habanero peppers). Results of 16S rRNA gene sequencing revealed that the variability of Drosophila gut microbiome can be driven mainly by genetic factors. When the abundance of these communities is considered, pepper-containing diets also appear to have an effect. The most relevant change in microbial composition was the increment of Lactobacillaceae and Acetobacteraceae abundance in the pepper-containing diets in comparison with the controls in Oregon-RC and Berlin-K. Regression analysis demonstrated that this enhancement was associated with the content of phenolic compounds and carotenoids of the peppers utilized in this study; specifically, to the concentration of β-carotene, β-cryptoxanthin, myricetin, quercetin, and apigenin.
Systematic Analysis of the DNA Methylase and Demethylase Gene Families in Rapeseed (Brassica napus L.) and Their Expression Variations After Salt and Heat stresses
Authors: Fan Shihang , Liu Hongfang , Liu Jing , Hua Wei , Xu Shouming , Li Jun
Published: January 2020

DNA methylation is a process through which methyl groups are added to the DNA molecule, thereby modifying the activity of a DNA segment without changing the sequence. Increasing evidence has shown that DNA methylation is involved in various aspects of plant growth and development via a number of key processes including genomic imprinting and repression of transposable elements. DNA methylase and demethylase are two crucial enzymes that play significant roles in dynamically maintaining genome DNA methylation status in plants. In this work, 22 DNA methylase genes and six DNA demethylase genes were identified in rapeseed (Brassica napus L.) genome. These DNA methylase and DNA demethylase genes can be classified into four (BnaCMTs, BnaMET1s, BnaDRMs and BnaDNMT2s) and three (BnaDMEs, BnaDML3s and BnaROS1s) subfamilies, respectively. Further analysis of gene structure and conserved domains showed that each sub-class is highly conserved between rapeseed and Arabidopsis. Expression analysis conducted by RNA-seq as well as qRT-PCR suggested that these DNA methylation/demethylation-related genes may be involved in the heat/salt stress responses in rapeseed. Taken together, our findings may provide valuable information for future functional characterization of these two types of epigenetic regulatory enzymes in polyploid species such as rapeseed, as well as for analyzing their evolutionary relationships within the plant kingdom.
Model and Experimental Characteristics of a Pneumatic Linear Peristaltic Actuator
Authors: Falcão Carneiro João , Pinto João Bravo , Gomes de Almeida Fernando , Fateri Miranda
Published: January 2020

Pneumatic linear peristaltic actuators present several potential advantages over conventional ones such as low cost, virtually unlimited stroke, and an easy implementation of curved motion profiles. However, the body of this type of actuators also suffers from high mechanical stress, leading to a decrease in the hose wall thickness, which leads to increased leakages between chambers. One way to potentially minimize this problem is to impose the force instead of the displacement between rollers. This paper describes the model and experimental characteristics of a new prototype of a linear pneumatic peristaltic actuator where either the force or the displacement between rollers can be imposed. Namely, experimental friction characteristics and the leakage between chambers are determined in the configuration where the force between rollers is imposed. Lastly, a third-order linear model is experimentally identified. Therefore, this study establishes the basis for future research focused on the service life and leakage obtained whenever the force between rollers is imposed.
A Framework for Word Embedding Based Automatic Text Summarization and Evaluation
Authors: Hailu Tulu Tilahun , Yu Junqing , Fantaye Tessfu Geteye
Published: January 2020

Text summarization is a process of producing a concise version of text (summary) from one or more information sources. If the generated summary preserves meaning of the original text, it will help the users to make fast and effective decision. However, how much meaning of the source text can be preserved is becoming harder to evaluate. The most commonly used automatic evaluation metrics like Recall-Oriented Understudy for Gisting Evaluation (ROUGE) strictly rely on the overlapping n-gram units between reference and candidate summaries, which are not suitable to measure the quality of abstractive summaries. Another major challenge to evaluate text summarization systems is lack of consistent ideal reference summaries. Studies show that human summarizers can produce variable reference summaries of the same source that can significantly affect automatic evaluation metrics scores of summarization systems. Humans are biased to certain situation while producing summary, even the same person perhaps produces substantially different summaries of the same source at different time. This paper proposes a word embedding based automatic text summarization and evaluation framework, which can successfully determine salient top-n sentences of a source text as a reference summary, and evaluate the quality of systems summaries against it. Extensive experimental results demonstrate that the proposed framework is effective and able to outperform several baseline methods with regard to both text summarization systems and automatic evaluation metrics when tested on a publicly available dataset.
Characterizing the Performance of Ternary Concrete Mixtures Involving Slag and Metakaolin
Authors: Sullivan Matthew S. , Chorzepa Mi G. , Durham Stephan A.
Published: January 2020

Ternary blends of cementitious materials are investigated. A cement replacement level of 45% is used for all ternary mixtures consisting of 15% metakaolin and 30% slag replacements. Three metakaolin and two blast furnace slag, referred to as ‘slag’ for short, products commercially available are used to compare performance in ternary blends. A mixture with a 45% fly ash replacement is included to serve as a benchmark for performance. The control mixture contains 422 kg of cement per cubic meter of concrete, and a water-to-cementitious material ratio of 0.43 is used for all mixtures with varying dosages of superplasticizer to retain workability. Mixtures are tested for mechanical properties, durability, and volumetric stability. Mechanical properties include compression, split-cylinder tension, modulus of rupture, and dynamic Young’s modulus. Durability measures are comprised of rapid chloride-ion penetrability, sulfate resistance, and alkali–silica reactivity. Finally, the measure of dimensional stability is assessed by conducting drying shrinkage and coefficient of thermal expansion tests. Results indicate that ternary mixtures including metakaolin perform similarly to the control with respect to mechanical strength. It is concluded that ternary blends perform significantly better than both control and fly ash benchmark in tests measuring durability. Furthermore, shrinkage is reduced while the coefficients of thermal expansion are slightly higher than control and the benchmark.
Surface Quality Assessment after Milling AZ91D Magnesium Alloy Using PCD Tool
Authors: Zagórski Ireneusz , Korpysa Jarosław
Published: January 2020

Surface roughness is among the key indicators describing the quality of machined surfaces. Although it is an aggregate of several factors, the condition of the surface is largely determined by the type of tool and the operational parameters of machining. This study sought to examine the effect that particular machining parameters have on the quality of the surface. The investigated operation was the high-speed dry milling of a magnesium alloy with a polycrystalline diamond (PCD) cutting tool dedicated for light metal applications. Magnesium alloys have low density, and thus are commonly used in the aerospace or automotive industries. The state of the Mg surfaces was assessed using the 2D surface roughness parameters, measured on the lateral and the end face of the specimens, and the end-face 3D area roughness parameters. The description of the surfaces was complemented with the surface topography maps and the Abbott–Firestone curves of the specimens. Most 2D roughness parameters were to a limited extent affected by the changes in the cutting speed and the axial depth of cut, therefore, the results from the measurements were subjected to statistical analysis. From the data comparison, it emerged that PCD-tipped tools are resilient to changes in the cutting parameters and produce a high-quality surface finish.
Platelet-Rich Plasma in Maxillary Sinus Augmentation: Systematic Review
Authors: Ortega-Mejia Holmes , Estrugo-Devesa Albert , Saka-Herrán Constanza , Ayuso-Montero Raúl , López-López José , Velasco-Ortega Eugenio
Published: January 2020

Background: Sinus augmentation can be performed with or without grafting biomaterials, and to date, there is no quality evidence regarding the augmentation of the sinus floor using only platelet concentrates, which can improve the healing period and enhance bone regeneration by stimulating angiogenesis and bone formation. The main objective of this paper was to assess the effect of the sole use of platelet concentrates in sinus augmentation in terms of newly formed bone, augmented bone height, and clinical outcomes and to assess the additional beneficial effects of platelet-rich fibrin (PRF) in combination with other grafting biomaterials. Methods: A systematic review was conducted following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Pooled analyses were performed with the Review Manager software. Results: For sinus elevation only using platelet concentrates, 11 studies met the inclusion criteria and were included for qualitative synthesis. Only one study was a clinical trial, which reported improved outcomes for the allograft group compared to the titanium-PRF (T-PRF) group. A total of 12 studies where PRF was used in addition to grafting biomaterials met eligibility criteria and were included in the review. Results from meta-analyses provided no additional beneficial effects of PRF in sinus augmentation in terms of bone height and percentage of soft tissue area. There was a statistically significant lower percentage of residual bone substitute material in the PRF (+) group compared to the PRF (−) group. The percentage of newly formed bone was slightly higher in the PRF (+) group, but this was not statistically significant. Conclusion: There is no robust evidence to make firm conclusions regarding the beneficial effects of the sole use of platelet concentrates in sinus augmentation. However, studies have shown favorable outcomes regarding implant survival, bone gain, and bone height. The use of PRF with other grafting biomaterials appears to provide no additional beneficial effects in sinus lift procedures, but they may improve the healing period and bone formation. Well-conducted randomized clinical trials (RCTs) are necessary to confirm the available results to provide recommendations for the clinical practice.
Dolomite-Foamed Bioactive Silicate Scaffolds for Bone Tissue Repair
Authors: Fiume Elisa , Tulyaganov Dilshat , Ubertalli Graziano , Verné Enrica , Baino Francesco
Published: January 2020

The use of three-dimensional (3D) scaffolds is recognized worldwide as a valuable biomedical approach for promoting tissue regeneration in critical-size bone defects. Over the last 50 years, bioactive glasses have been intensively investigated in a wide range of different clinical applications, from orthopedics to soft tissue healing. Bioactive glasses exhibit the unique capability to chemically bond to the host tissue and, furthermore, their processing versatility makes them very appealing due to the availability of different manufacturing techniques for the production of porous and interconnected synthetic bone grafts able to support new tissue growth over the whole duration of the treatment. As a novel contribution to the broad field of scaffold manufacturing, we report here an effective and relatively easy method to produce silicate glass-derived scaffolds by using, for the first time in the biomedical field, dolomite powder as a foaming agent for the formation of 3D bone-like porous structures. Morphological/structural features, crystallization behavior, and in vitro bioactivity in a simulated body fluid (SBF) were investigated. All the tested scaffolds were found to fulfil the minimum requirements that a scaffold for osseous repair should exhibit, including porosity (65–83 vol.%) and compressive strength (1.3–3.9 MPa) comparable to those of cancellous bone, as well as hydroxyapatite-forming ability (bioactivity). This study proves the suitability of a dolomite-foaming method for the production of potentially suitable bone grafts based on bioactive glass systems.
Formability of the 5754-Aluminum Alloy Deformed by a Modified Repetitive Corrugation and Straightening Process
Authors: Ezequiel Marco , Elizalde Sergio , Cabrera José-María , Picas Josep , Figueroa Ignacio A. , Alfonso Ismeli , Gonzalez Gonzalo
Published: January 2020

Sheets of 5754-aluminum alloy processed by a modified repetitive corrugation and straightening (RCS) process were tested in order to measure their formability. For this purpose, forming limit curves were derived. They showed that the material forming capacity decreased after being processed by RCS. However, they kept good formability in the initial stages of the RCS process. The formability study was complemented with microstructural analysis (derivation of texture) and mechanical tests to obtain the strain-rate sensitivity. The texture analysis was done by employing X-ray diffraction, obtaining pole figures, and the orientation distribution function. It was noticed that the initial texture was conserved after successive RCS passes, but the intensity dropped. RCS process did not induce β-fiber, contrary to common deformation process. The strain-rate sensitivity coefficient was measured through tensile tests at different temperatures and strain rates; the coefficient of the samples processed after one and two passes were still relatively high, indicating the capacity to delay necking, in agreement with the good formability observed in the initial passes of the RCS process.
A New Biomimetic Composite Structure with Tunable Stiffness and Superior Toughness via Designed Structure Breakage
Authors: Wang Xiaohan , Li Dongxu
Published: January 2020

Mimicking natural structures has been highly pursued recently in composite structure design to break the bottlenecks in the mechanical properties of the traditional structures. Bone has a remarkable comprehensive performance of strength, stiffness and toughness, due to the intricate hierarchical microstructures and the sacrificial bonds within the organic components. Inspired by the strengthening and toughening mechanisms of cortical bone, a new biomimetic composite structure, with a designed progressive breakable internal construction mimicking the sacrificial bond, is proposed in this paper. Combining the bio-composite staggered plate structure with the sacrificial bond-mimicking construction, our new structure can realize tunable stiffness and superior toughness. We established the constitutive model of the representative unit cell of our new structure, and investigated its mechanical properties through theoretical analysis, as well as finite element modeling (FEM) and simulation. Two theoretical relations, respectively describing the elastic modulus decline ratio and the unit cell toughness promotion, are derived as functions of the geometrical parameters and the material parameters, and validated by simulation. We hope that this work can lay the foundation for the stiffness tunable and high toughness biomimetic composite structure design, and provide new ideas for the development of sacrificial bond-mimicking strategies in bio-inspired composite structures.
Modeling of Energy Demand and Savings Associated with the Use of Epoxy-Phase Change Material Formulations
Authors: Arce Elena , Agrawal Richa , Suárez Andrés , Febrero Lara , Luhrs Claudia C.
Published: January 2020

This manuscript integrates the experimental findings of recently developed epoxy-phase change material (PCM) formulations with modeling efforts aimed to determine the energy demands and savings derived from their use. The basic PCM system employed was composed of an epoxy resin, a thickening agent, and nonadecane, where the latter was the hydrocarbon undergoing the phase transformation. Carbon nanofibers (CNF) and boron nitride (BN) particulates were used as heat flow enhancers. The thermal conductivities, densities, and latent heat determined in laboratory settings were introduced in a model that calculated, using EnergyPlus software, the energy demands, savings and temperature profiles of the interior and the walls of a shelter for six different locations on Earth. A shipping container was utilized as exemplary dwelling. Results indicated that all the epoxy-PCM formulations had a positive impact on the total energy savings (between 16% and 23%) for the locations selected. The use of CNF and BN showed an increase in performance when compared with the formulation with no thermal filler additives. The formulations selected showed great potential to reduce the energy demands, increase savings, and result in more adequate temperatures for living and storage spaces applications.
High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc
Authors: Al-Halhouli Ala’aldeen , Doofesh Zaid , Albagdady Ahmed , Dietzel Andreas
Published: January 2020

The fabrication and testing of microfluidic spinning compact discs with embedded trapezoidal microchambers for the purpose of inertial microparticle focusing is reported in this article. Microparticle focusing channels require small features that cannot be easily fabricated in acrylic sheets and are complicated to realize in glass by traditional lithography techniques; therefore, the fabrication of microfluidic discs with femtosecond laser ablation is reported for the first time in this paper. It could be demonstrated that high-efficiency inertial focusing of 5 and 10 µm particles is achieved in a channel with trapezoidal microchambers regardless of the direction of disc rotation, which correlates to the dominance of inertial forces over Coriolis forces. To achieve the highest throughput possible, the suspension concentration was increased from 0.001% (w/v) to 0.005% (w/v). The focusing efficiency was 98.7% for the 10 µm particles and 93.75% for the 5 µm particles.
High-Pressure Sound Velocity Measurements of Liquids Using In Situ Ultrasonic Techniques in a Multianvil Apparatus
Authors: Jing Zhicheng , Yu Tony , Xu Man , Chantel Julien , Wang Yanbin
Published: January 2020

Sound velocity and equation of state of liquids provide important constraints on the generation, presence, and transport of silicate and metallic melts in the Earth’s interior. Unlike their solid counterparts, these properties of liquids pose great technical challenges to high-pressure measurements and are poorly constrained. Here we present the technical developments that have been made at the GSECARS beamline 13-ID-D of the Advanced Photon Source for the past several years for determination of sound velocity of liquids using the ultrasonic techniques in a 1000-ton Kawai-type multianvil apparatus. Temperature of the sound velocity measurements has been extended to ~2400 K at 4 GPa and ~2000 K at 8 GPa to enable studies of liquids with very high melting temperatures, such as the silicate liquids.
Adsorption of Salmonella in Clay Minerals and Clay-Based Materials
Authors: Pardo Laura , Domínguez-Maqueda Marta , Cecilia Juan Antonio , Pozo Rodríguez Manuel , Osajima Josy , Moriñigo Miguel Ángel , Franco Francisco
Published: January 2020

A series of clay minerals and clay-based materials have been tested to eliminate one of the most dangerous bacteria we can find in the water: Salmonella. It has been proven that the use of clays and their PCH materials can be a suitable method for removing Salmonella from water. The results of this initial study show that all the materials analyzed have great salmonella adsorption capacities ranging from the lowest value observed in the mont-PCH sample (0.29 × 1010 CFU g−1) to the highest value observed in the natural palygorskite sample (1.52 × 1010 CFU g−1). Macroporosity, accessible external surface area, and the presence of silanol groups in the external surface of the particles appears to be the controlling factors for Salmonella adsorption capacity while it seems that the structural characteristics of the clay minerals and their respective PCH does not affect the adsorption capacity.
Grammatikopoulosite, NiVP, a New Phosphide from the Chromitite of the Othrys Ophiolite, Greece
Authors: Bindi Luca , Zaccarini Federica , Ifandi Elena , Tsikouras Basilios , Stanley Chris , Garuti Giorgio , Mauro Daniela
Published: January 2020

Grammatikopoulosite, NiVP, is a new phosphide discovered in the podiform chromitite and hosted in the mantle sequence of the Othrys ophiolite complex, central Greece. The studied samples were collected from the abandoned chromium mine of Agios Stefanos. Grammatikopoulosite forms small crystals (from 5 μm up to about 80 μm) and occurs as isolated grains. It is associated with nickelphosphide, awaruite, tsikourasite, and an undetermined V-sulphide. It is brittle and has a metallic luster. In plane-polarized light, it is creamy-yellow, weakly bireflectant, with measurable but not discernible pleochroism and slight anisotropy with indeterminate rotation tints. Internal reflections were not observed. Reflectance values of mineral in air (R1, R2 in %) are: 48.8–50.30 at 470 nm, 50.5–53.5 at 546 nm, 51.7–55.2 at 589 nm, and 53.2–57.1 at 650 nm. Five spot analyses of grammatikopoulosite give the average composition: P 19.90, S 0.41, Ni 21.81, V 20.85, Co 16.46, Mo 16.39, Fe 3.83, and Si 0.14, total 99.79 wt %. The empirical formula of grammatikopoulosite—based on Σ(V + Ni + Co + Mo + Fe + Si) = 2 apfu, and taking into account the structural results—is (Ni0.57Co0.32Fe0.11)Σ1.00(V0.63Mo0.26Co0.11)Σ1.00(P0.98S0.02)Σ1.00. The simplified formula is (Ni,Co)(V,Mo)P and the ideal formula is NiVP, which corresponds to Ni 41.74%, V 36.23%, P 22.03%, total 100 wt %. The density, calculated on the basis of the empirical formula and single-crystal data, is 7.085 g/cm3. The mineral is orthorhombic, space group Pnma, with a = 5.8893(8), b = 3.5723(4), c = 6.8146(9) Å, V = 143.37(3) Å3, and Z = 4. The mineral and its name have been approved by the Commission of New Minerals, Nomenclature and Classification of the International Mineralogical Association (IMA 2019-090). The mineral honors Tassos Grammatikopoulos, geoscientist at the SGS Canada Inc., for his contribution to the economic mineralogy and mineral deposits of Greece.
Obesity Is Less Frequently Associated with Cognitive Impairment in Elderly Individuals: A Cross-Sectional Study in Yogyakarta, Indonesia
Authors: Vidyanti Amelia Nur , Hardhantyo Muhammad , Wiratama Bayu Satria , Prodjohardjono Astuti , Hu Chaur-Jong
Published: January 2020

Obesity is one of the factors associated with cognitive impairment. However, obesity may differently affect cognitive function in different age groups, and scarce data are available from low- and middle-income countries. This cross-sectional study aimed to identify the association between obesity and cognitive impairment among 143 elderly individuals in Yogyakarta. We recorded the sociodemographic factors and some comorbidities, also measured the body mass index as a parameter of obesity, cognitive function using Montreal Cognitive Assessment—Indonesia, mood condition and depression status using geriatric depression scale-short form, as well as the daily life function using Activity of Daily Living and Instrumental Activity of Daily Living. After adjustment for the sociodemographic and comorbidities, we found that subjects with older age were more likely to have cognitive impairment (odds ratio [OR] 3.544, 95%CI: 1.36–9.22, p < 0.01) and compared with elderly individuals with normal weight, obese elderly individuals were 40% less likely to have cognitive impairment (OR 0.604, 95%CI: 0.39–0.95, p < 0.05). This study suggests that obesity in elderly individuals is less frequently associated with cognitive impairment. These findings support the reverse causation mechanism related to body mass index (BMI) and cognitive impairment in low/middle-income countries.
The Effects of Cholecalciferol Supplementation on Vitamin D Status Among a Diverse Population of Collegiate Basketball Athletes: A Quasi-Experimental Trial
Authors: Sekel Nicole M. , Gallo Sina , Fields Jennifer , Jagim Andrew R. , Wagner Tammy , Jones Margaret T.
Published: January 2020

Vitamin D may play a role in performance and injury risk, yet the required supplementation dosage for collegiate athletes is unclear. The objective of this study was to define the dosage of vitamin D3 supplementation required to beneficially affect serum 25-hydroxyvitamin D (25(OH)D) among a sample of collegiate basketball athletes. This was a quasi-experimental trial, participants were allocated to one of three groups of vitamin D3 daily at the beginning of pre-season training and dependent upon their baseline vitamin D status as follows: insufficient (<75 nmol/L) to 10,000 IU, sufficient (75–125 nmol/L) to 5000 IU and optimal (>125 nmol/L) to no supplementation. Follow-up assessments were completed ~ 5 months later in post season. The majority (n = 13) were allocated to 10,000 IU vs. n = 5 to 5000 IU and n = 2 to no supplementation. The 10,000 IU group showed the greatest change (35.0 ± 27.0 nmol/L) vs. the 5000 IU group (−9.3 ± 9.6 nmol/L) and no supplementation group (−41.6 ± 11.7 nmol/L, p < 0.01). Only 1 participant reached optimal status in the 10,000 IU group. In conclusion, a daily dosage of 10,000 IU vitamin D3 supplementation mitigated the high prevalence of vitamin D deficiency among collegiate basketball players but was insufficient for all to reach sufficient levels.
Dietary Synbiotic Supplementation Protects Barrier Integrity of Hepatocytes and Liver Sinusoidal Endothelium in a Mouse Model of Chronic-Binge Ethanol Exposure
Authors: Han Yingchun , Glueck Bryan , Shapiro David , Miller Aaron , Roychowdhury Sanjoy , Cresci Gail A. M.
Published: January 2020

Alcohol overconsumption disrupts the gut microbiota and intestinal barrier, which decreases the production of beneficial microbial metabolic byproducts and allows for translocation of pathogenic bacterial-derived byproducts into the portal-hepatic circulation. As ethanol is known to damage liver sinusoidal endothelial cells (LSEC), here we evaluated dietary supplementation with a previously studied synbiotic on gut microbial composition, and hepatocyte and LSEC integrity in mice exposed to ethanol. We tested a chronic-binge ethanol feeding mouse model in which C57BL/6 female mice were fed ethanol (5% vol/vol) for 10 days and provided a single ethanol gavage (5 g/kg body weight) on day 11, 6 h before euthanasia. An ethanol-treatment group also received oral supplementation daily with a synbiotic; and an ethanol-control group received saline. Control mice were pair-fed and isocalorically substituted maltose dextran for ethanol over the entire exposure period; they received a saline gavage daily. Ethanol exposure decreased gut microbial abundance and diversity. This was linked with diminished expression of adherens junction proteins in hepatocytes and dysregulated expression of receptors for advanced glycation end-products; and this coincided with reduced expression of endothelial barrier proteins. Synbiotic supplementation mitigated these effects. These results demonstrate synbiotic supplementation, as a means to modulate ethanol-induced gut dysbiosis, is effective in attenuating injury to hepatocyte and liver endothelial barrier integrity, highlighting a link between the gut microbiome and early stages of acute liver injury in ethanol-exposed mice.
Nutraceuticals and Hypertensive Disorders in Pregnancy: The Available Clinical Evidence
Authors: Fogacci Silvia , Fogacci Federica , Cicero Arrigo F.G.
Published: January 2020

The aim of the present critical review is to summarize the available clinical evidence supporting the use of some dietary supplements that have been shown to lower blood pressure in hypertensive pregnant women. A systematic search strategy was carried out to identify trials in MEDLINE (National Library of Medicine, Bethesda, Maryland, MD, USA; January 1980 to September 2019) and the Cochrane Register of Controlled Trials (The Cochrane Collaboration, Oxford, UK). The terms ‘nutraceuticals’, ‘dietary supplements’, ‘pregnancy’, ‘pre-eclampsia’, ‘clinical trial’, and ‘human’ were incorporated into an electronic search strategy. The references of the identified studies and review articles were reviewed to look for additional studies of interest. We preferably selected papers that reported recent comprehensive reviews or meta-analysis, or original clinical trials of substances with blood pressure-lowering or vascular protective effect in pregnancy. There is a relative body of evidence that supports the use of calcium, vitamin D, folic acid, and resveratrol in preventing the development of hypertensive disorders in pregnancy, and evidence supporting drug treatment too. Further clinical research is advisable to identify the dosage and timing of the supplementation, the group of women that might benefit the most from this approach, and the nutraceuticals with the best cost-effectiveness and risk-benefit ratio for widespread use in clinical practice.