bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of ionic liquids as entrainers on the dynamic behavior of ethanol-water extractive columns
Authors: Ramírez-Corona Nelly , Schramm-Flores Andrés , Reyes-Lombardo Sofía , Jiménez-Gutiérrez Arturo
Published: November 2019

Ionic liquids (ILs) have been recently considered as potential entrainers for extractive distillation. The use of ILs may affect the vapor-liquid properties to aid the separation of azeotropic mixtures. In particular, their effectiveness has been observed for ethanol dehydration, showing promising perspectives for their industrial implementation. However, there is still a lack of information about the effect of ILs on the system controllability. The objective of this work is to explore the dynamic implications of the use of two types of ionic liquids on the ethanol dehydration process. An equimolar feed mixture of ethanol and water was considered, and different IL concentrations were tested. The results show that changing the IL concentration affect the degree of stabilization of the product stream, even when smooth dynamic responses were in many cases observed.
Outcomes of Patients with Nelson’s Syndrome after Primary Treatment: A Multicenter Study from 13 UK Pituitary Centers
Authors: Fountas Athanasios , Lim Eugenie S , Drake William M , Powlson Andrew S , Gurnell Mark , Martin Niamh M , Seejore Khyatisha , Murray Robert D , MacFarlane James , Ahluwalia Rupa , Swords Francesca , Ashraf Muhammad , Pal Aparna , Chong Zhuomin , Freel Marie , Balafshan Tala , Purewal Tejpal S , Speak Rowena G , Newell-Price John , Higham Claire E , Hussein Ziad , Baldeweg Stephanie E , Dales Jolyon , Reddy Narendra , Levy Miles J , Karavitaki Niki
Published: November 2019

Context

Long-term outcomes of patients with Nelson’s syndrome (NS) have been poorly explored, especially in the modern era.

Objective

To elucidate tumor control rates, effectiveness of various treatments, and markers of prognostic relevance in patients with NS.

Patients, design, and setting

Retrospective cohort study of 68 patients from 13 UK pituitary centers with median imaging follow-up of 13 years (range 1–45) since NS diagnosis.

Results

Management of Cushing’s disease (CD) prior to NS diagnosis included surgery+adrenalectomy (n = 30; eight patients had 2 and one had 3 pituitary operations), surgery+radiotherapy+adrenalectomy (n = 17; two received >1 courses of irradiation, two had ≥2 pituitary surgeries), radiotherapy+adrenalectomy (n = 2), and adrenalectomy (n = 19). Primary management of NS mainly included surgery, radiotherapy, surgery+radiotherapy, and observation; 10-year tumor progression-free survival was 62% (surgery 80%, radiotherapy 52%, surgery+radiotherapy 81%, observation 51%). Sex, age at CD or NS diagnosis, size of adenoma (micro-/macroadenoma) at CD diagnosis, presence of pituitary tumor on imaging prior adrenalectomy, and mode of NS primary management were not predictors of tumor progression. Mode of management of CD before NS diagnosis was a significant factor predicting progression, with the group treated by surgery+radiotherapy+adrenalectomy for their CD showing the highest risk (hazard ratio 4.6; 95% confidence interval, 1.6–13.5). During follow-up, 3% of patients had malignant transformation with spinal metastases and 4% died of aggressively enlarging tumor.

Conclusions

At 10 years follow-up, 38% of the patients diagnosed with NS showed progression of their corticotroph tumor. Complexity of treatments for the CD prior to NS diagnosis, possibly reflecting corticotroph adenoma aggressiveness, predicts long-term tumor prognosis.
The fenestrae-associated protein Plvap regulates the rate of blood-borne protein passage into the hypophysis
Authors: Gordon Ludmila , Blechman Janna , Shimoni Eyal , Gur Dvir , Anand-Apte Bela , Levkowitz Gil
Published: November 2019

To maintain body homeostasis, endocrine systems must detect and integrate blood-borne peripheral signals. This is mediated by fenestrae, specialized permeable pores in the endothelial membrane. Plasmalemma vesicle-associated protein (Plvap) is located in the fenestral diaphragm and is thought to play a role in the passage of proteins through the fenestrae. However, this suggested function has yet to be demonstrated directly. We studied the development of fenestrated capillaries in the hypophysis, a major neuroendocrine interface between the blood and brain. Using a transgenic biosensor to visualize the vascular excretion of the genetically tagged plasma protein DBP-EGFP, we show that the developmental acquisition of vascular permeability coincides with differential expression of zebrafish plvap orthologs in the hypophysis versus brain. Ultrastructural analysis revealed that plvapb mutants display deficiencies in fenestral diaphragms and increased density of hypophyseal fenestrae. Measurements of DBP-EGFP extravasation in plvapb mutants provided direct proof that Plvap limits the rate of blood-borne protein passage through fenestrated endothelia. We present the regulatory role of Plvap in the development of blood-borne protein detection machinery at a neuroendocrine interface through which hormones are released to the general circulation.
Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm
Authors: Linneberg-Agerholm Madeleine , Wong Yan Fung , Romero Herrera Jose Alejandro , Monteiro Rita S. , Anderson Kathryn G. V. , Brickman Joshua M.
Published: November 2019

Embryonic stem cells (ESCs) exist in at least two states that transcriptionally resemble different stages of embryonic development. Naïve ESCs resemble peri-implantation stages and primed ESCs the pre-gastrulation epiblast. In mouse, primed ESCs give rise to definitive endoderm in response to the pathways downstream of Nodal and Wnt signalling. However, when these pathways are activated in naïve ESCs, they differentiate to a cell type resembling early primitive endoderm (PrE), the blastocyst-stage progenitor of the extra-embryonic endoderm. Here, we apply this context dependency to human ESCs, showing that activation of Nodal and Wnt signalling drives the differentiation of naïve pluripotent cells toward extra-embryonic PrE, or hypoblast, and these can be expanded as an in vitro model for naïve extra-embryonic endoderm (nEnd). Consistent with observations made in mouse, human PrE differentiation is dependent on FGF signalling in vitro, and we show that, by inhibiting FGF receptor signalling, we can simplify naïve pluripotent culture conditions, such that the inhibitor requirements closer resemble those used in mouse. The expandable nEnd cultures reported here represent stable extra-embryonic endoderm, or human hypoblast, cell lines.

This article has an associated ‘The people behind the papers’ interview.
Thrust generation during steady swimming and acceleration from rest in anguilliform swimmers
Authors: Du Clos Kevin T. , Dabiri John O. , Costello John H. , Colin Sean P. , Morgan Jennifer R. , Fogerson Stephanie M. , Gemmell Brad J.
Published: November 2019

Escape swimming is a crucial behavior by which undulatory swimmers evade potential threats. The hydrodynamics of escape swimming have not been well studied, particularly for anguilliform swimmers, such as the sea lamprey Petromyzon marinus. For this study, we compared the kinematics and hydrodynamics of larval sea lampreys with those of lampreys accelerating from rest during escape swimming. We used experimentally derived velocity fields to calculate pressure fields and distributions of thrust and drag along the body. Lampreys initiated acceleration from rest with the formation of a high-amplitude body bend at approximately one-quarter body length posterior to the head. This deep body bend produced two high-pressure regions from which the majority of thrust for acceleration was derived. In contrast, steady swimming was characterized by shallower body bends and negative-pressure-derived thrust, which was strongest near the tail. The distinct mechanisms used for steady swimming and acceleration from rest may reflect the differing demands of the two behaviors. High-pressure-based mechanisms, such as the one used for acceleration from rest, could also be important for low-speed maneuvering during which drag-based turning mechanisms are less effective. The design of swimming robots may benefit from the incorporation of such insights from unsteady swimming.
Restoration of defaced serial numbers using lock-in infrared thermography (Part I)
Authors: Unobe Ikwulono , Lau Lisa , Kalivas John , Rodriguez Rene , Sorensen Andrew
Published: November 2019

Infrared thermal imaging is an evolving approach useful in non-destructive evaluation of materials for industrial and
research purposes. This study investigates the use of this method in combination with multivariate data analysis as an
alternative to chemical etching; a destructive method currently used to recover defaced serial numbers stamped in metal.
This process involves several unique aspects, each of which works to overcome some pertinent challenges associated
with the recovery of defaced serial numbers. Infrared thermal imaging of metal surfaces provides thermal images sensitive
to local differences in thermal conductivity of regions of plastic strain existing below a stamped number. These strains are
created from stamping pressures distorting the atomic crystalline structure of the metal and extend to depths beneath the
stamped number. These thermal differences are quite small and thus not readily visible from the raw thermal images of an
irregular surface created by removing the stamped numbers. As such, further enhancement is usually needed to identify
the subtle variations. The multivariate data analysis method, principal component analysis, is used to enhance these subtle
variations and aid the recovery of the serial numbers. Multiple similarity measures are utilised to match recovered numbers
to several numerical libraries, followed by application of various fusion rules to achieve consensus identification.
Restoration of defaced serial numbers using lock-in infrared thermography (Part II)
Authors: Unobe Ikwulono , Lau Lisa , Kalivas John , Rodriguez Rene , Sorensen Andrew
Published: November 2019

This paper details continuing work on the development of a substantive non-destructive method to recover
defaced serial numbers stamped or laser engraved into metallic objects based on lock-in infrared thermography. This
method relies on the existence of a local zone of plastic strain created from stamping pressures in mechanically stamped
pieces and a heat-affected zone in laser engraved samples, both extending to depths below the visible characters. The
grain structure within these zones is dislocated due to the external forces applied. These deformed areas are exposed to
the surface when the serial numbers are defaced. Infrared thermography utilises the change in thermal conductivity,
based on local variation in the thermal gradient from thermal energy applied at the surface. Observation of the thermal
gradient at the surface as it propagates through the object allows for identification of these deformed regions and
subsequent recovery of the serial number. Principal component analysis is used to enhance the thermographic images.
Pseudo Zernike moments and subsequently multiple similarity measures are utilised to identify the numbers based on a
reference library of numbers. Several fusion rules are used to obtain a consensus across the similarity measures. This
process is tested on several datasets including stamped numbers on a gun barrel, laser engraved numbers on a needle
holder and the defaced vehicle identification number of a stolen motorcycle.
Panfletos para pirilampos e magnólias: Profundanças 2 e a escrevivência da mulher negra como movimento de re-existência
Authors: Santos de Matos Elisiane Santos , Pereira do Sacramento Sandra Maria
Published: November 2019

O presente artigo trata a respeito da necessária revisão do cânone literário sob uma perspectiva interseccional, buscando entender como as relações de poder, que subjazem às escolhas das obras literárias referenciais de cada país, concorreram para invisibilidade de obras de autoria feminina e, em maior medida, de autoria de mulheres negras. Tendo como corpus literário o poema Panfletos para pirilampos e magnólias, da poeta negra latino-americana Rita Santana, intenta-se compreender a importância de se realizar rasuras nas representações do presente, respeitando o lugar de fala e promovendo a auto representação das mulheres escritoras, que por muito tempo foram relegadas ao lugar da não representação.  Para tanto, utiliza-se como arcabouço teórico: Coutinho (1996); Schmidt (2017); Spivak (2010); Davis (2016); Ribeiro (2017); entre outros.
The state of care: will innovation and integration improve access?
Authors: Frankova Helena
Published: November 2019

It is that time of year again: the Care Quality Commission's annual report on the state of care in all sectors was published in mid-October. What are the key themes for this year? Helena Frankova investigates
Acute renal failure in adult horses
Authors: Gough Rachel , McGovern Kate
Published: November 2019

Renal disease can be pre-, intrinsic or post-renal in origin, with pre-renal disease being the most common and generally straightforward to correct if the primary problem can be addressed. Intrinsic renal disease is relatively rare in the horse overall. Nephrotoxic drugs have been thought to be the most common cause of intrinsic renal disease, but their clinical significance is now being questioned. Treatment options are usually supportive, with intravenous fluid therapy being the mainstay. Dialysis is becoming more common, although it is still a rare treatment.
Exotic threats to UK equines
Authors: Robin Matthew
Published: November 2019

Historically, veterinary surgeons in the UK have had little cause to consider many vector-borne infections that are of great significance elsewhere in the world. Primarily this has reflected the combination of a lack of the required vectors and climate conditions for disease transmission, combined with the geographical barrier to disease entry that being a small island provides. In recent years there have been significant changes in the global distribution of vector-borne diseases, and it has been suggested that these are associated with climate change and the increasing international movement of animals and animal products. Veterinary surgeons attending cases with clinical findings consistent with exotic disease, in particular in any equids that have travelled or are housed with equids that have travelled, must remain vigilant to the possibility of the disease occurring in areas currently considered disease-free. This article focuses on three such diseases that increasingly threaten the UK equine population: African horse sickness, piroplasmosis and West Nile virus infection.
Sobre Pessoas e Abelhas: teoria e prática no manuseio do conceito de cultura em contextos gerenciais
Authors: D'Ascenzi Luciano , Lima Luciana Leite
Published: November 2019

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2012.1.1.4026.95-121Trata-se de uma abordagem comparativa entre os conceitos de cultura e cultura organizacional, cada qual originado na antropologia e na teoria geral da administração respectivamente. Esse diálogo explicita as diferenças teóricas e as particularidades, possibilidades e os limites de sua aplicação, frente a essas duas procedências, quando em situações práticas. Sugerimos complementar o enfoque funcionalista, presente nas análises e práticas administrativas, com outros elementos relacionais presentes nos contextos de ação das estruturas locais. Finalmente, sugerimos que tal arremate poder-se-ia dar, eficazmente, por meio da incorporação da produção teórica e metodológica em ciências sociais, que, com a pesquisa empírica, vem demonstrando a possibilidade de apreensão da dinâmica cultural junto aos mais diversos lócus de estudo. Nossa proposta configura, então, em esforço de colaboração entre as mais diversas áreas das ciências sociais aplicadas.
Participação dos Trabalhadores na Gestão da Produção
Authors: Rachid Alessandra
Published: November 2019

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2013.2.2.4648.123-150O objetivo deste texto é analisar o envolvimento dos trabalhadores na gestão da produção, mostrando como este tema tem evoluído ao longo dos anos, tanto do ponto de vista da gestão, quanto de abordagens críticas. Para isso, foi realizado um levantamento bibliográfico tanto em textos clássicos no qual o envolvimento dos trabalhadores na gestão da produçãoé abordado, quanto sobre pesquisas mais recentes sobre o tema. Houve, nos anos 1980, uma sinalização de mudanças significativas no envolvimento dos trabalhadores com a gestão da produção, no entanto, pesquisas recentes apontam que estas avançaram até certo ponto, mas depois se estabilizaram.
Editorial
Authors: Bonacelli Maria Beatriz Machado , Santos Glicia Vieira dos
Published: November 2019

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2013.2.2.5955.5-8Apresenta a 2a. edição da Revista Gestão & Conexões (Management and Connections Journal), v2, n2, jul./dez. 2013.
Apresentação
Authors: Baranauskas Maria Cecília Calani
Published: November 2019

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2014.3.1.7853.17-20. Apresenta a Edição Especial: Inovação, Tecnologias Assistivas e Acessibilidade.
Expediente
Authors: Santos Glicia Vieira dos
Published: November 2019

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2014.3.1.7854.1-4. Apresenta a 3a. edição da Revista Gestão & Conexões (Management and Connections Journal), v3, n1, jan./jun. 2014.
Dios y Marx los conceptos eurocentristas que no permiten la filosofía en África y Latinoamérica
Authors: Cabañas Francisco Tomás González
Published: November 2019

Abstract en Español

El marxismo latinoamericano, como respuesta al teocentrismo medieval inoculado por la universidad como claustro del conocimiento, actúa como concepto enquistado en la filosofía política, vendría a ser como el opio de los intelectuales contemporáneos, bajo estas categorías eurocéntricas, de Dios y Marx, nos limitamos para comprender la realidad política y filosófica, desde esa inoculación educativa que se realiza desde lo filosófico, únicamente entendido como ejercicio disciplinar, asentada, no en el logos o en la intensidad filosófica, sino en la vara del pupitre, en la férula de la nota autoritaria que en el mundo formalmente aceptado de lo académico.

Palabras claves: Marxismo, Lationamericanismo, filosofía política, filosofía de la liberación.
Mkatashinga: Narratives of the Mutiny in ANC Camps in Angola (1983/84)
Authors: Zantsi Luvuyo
Published: November 2019

The 1984 mutiny in the Angolan camps of the African National Congress (ANC) has been the stuff of legends. For a long time two contradictory interpretations were prominent. One interpretation painted it as, completely, the work of apartheid agents and agent provocateurs. The other painted it as an instance where patriotic democrats took a stance for justice and they were crushed by an undemocratic ANC. The information that recently came out of the memoirs and biographies of former soldiers paints a more nuanced picture that reveals the situation to be more complex than the ANC's official view and those of its distractors. While there can be no way of absolutely ruling out enemy interference, all narratives point to the presence of genuine challenges that could have been handled better. The absence of senior leadership from the camps also ensured a weak response to these.
Myanmar's Citizenship Law as State Crime: A Case for the International Criminal Court
Authors: Lee Ronan
Published: November 2019

This article argues that Myanmar's authorities subject the Rohingya to human rights violations that can be accurately described as the crime of apartheid. Myanmar's discriminatory application of its citizenship laws and processes is central to this crime, yet while Myanmar is not a signatory to the Rome Statute of the International Criminal Court, the court's jurisdiction remains limited. However, Myanmar's government has brought this crime to the territory of International Criminal Court (ICC) member state Bangladesh. Because Myanmar's government insists upon Rohingya participation in discriminatory citizenship processes as a precondition of refugee repatriation to Myanmar, this presents the ICC with an opportunity to assert its jurisdiction. While current ICC investigation focusses mostly on alleged crimes committed by the Myanmar military, crimes associated with Myanmar's citizenship processes would likely be the responsibility of Myanmar's civilian government, including State Counsellor Aung San Suu Kyi, making Myanmar's civilian political leaders liable for the first time to ICC prosecution.
Vertical division of labour: a sociology of the work of remote organisers
Authors: Dujarier Marie-Anne
Published: November 2019

Contemporary work organisation is characterised by a persistent vertical division of labour between managers in charge of designing work at a distance and operational workers. This article focuses on the work of specific white collar workers called ‘remote organisers’, and how they face the challenge of performing a task that seems impossible and socially thankless. Results from a major qualitative and quantitative survey of large French organisations and consulting firms, show that the standardisation of methods, the Taylorisation of the implementation of tasks and resorting to abstraction are what makes their work sustainable and achievable. Finally, remote organisers build up a professional norm which consists in having a playful and game-like relationship with their work.
Agile methods as stress management tools? an empirical study
Authors: Pfeiffer Sabine , Sauer Stefan , Ritter Tobias
Published: November 2019

Project-based work is considered a prototype for modern knowledge work, but is also often linked to stress. Complementing or substituting for conventional project management, agile methods are on the rise, but the implications of these methods for stress on employees still remain largely hidden. This article presents the results from qualitative case studies in software development that show how diverse agile methods are lived in practice and how these variations affect stress levels. The results unveil how agile methods, under certain assumptions, can protect team members against stress and voluntary self-exploitation - offering a safe space that is, however, fragile and requires accompanying organisational backing.
The new union avoidance internationalism
Authors: Logan John
Published: November 2019

Since the 1950s, large management-side law firms have helped corporations in the USA resist union organising campaigns. Their sophisticated techniques and aggressive tactics have made it extraordinarily difficult for unions to organise in the private sector. Over the past decade, several large law firms that specialise in union avoidance have internationalised their operations, opening offices in Latin America, Europe and Asia, forming international alliances and using global standards to attack labour organisation and undermine labour rights. This article analyses the global union avoidance activities of the two largest management-side labour law firms in the USA: Littler Mendelson and Ogletree Deakins.
Clarifying dual-processing for marketing researchers
Authors: Hall Justin R. , Shaw Eric H.
Published: November 2019

Few would argue that the dual-processing model of cognition is one of the most influential psychology frameworks of our time. But despite its simplicity and elegance, it often leaves novices and experts alike confused. The purpose of this paper is to highlight and resolve four factors
contributing to this confusion. This research contributes by (1) clarifying the dual-processing model by proposing a framework that defines key terms and their relationships, (2) offering two terms (Default and Search) that can be used to organise cognitive processes, (3) explaining how different
cognitive processes operate, and (4) offering normative propositions for future marketing researchers interested in the dual-processing model.
Thermoacoustic Parameters Determination of Intermolecular Free-Length of
1-Butyl-2,3-dimethylimidazolium Chloride in Mixed Solvents at T = (298.15 to 313.15) K
Authors: Muchipali Sailaja , Pradhan Ranjan Kumar , Mohapatra Priyaranjan , Nanda Braja B.
Published: November 2019

The intermolecular free-length of 1-butyl-2,3-dimethylimidazolium chloride [bdmim]Cl in pure water as well as in tetra-n-butyl ammonium bromide (TBAB) + water at different concentrations of solute and at T = (298.15 to 313.15) K have been evaluated by making use of ultrasonic and thermoacoustical parameters followed by a comparative study. To accomplish this objective, thermoacoustical parameters for the above said solutions have been calculated. These parameters have been used to determine intermolecular free-length (Lf) for the solutions under study. The values of Lf obtained by thermoacoustical approach were tallied with the values obtained by well-known ultrasonic method (Schaaffs method). To the best of our understanding, this study is an innovative attempt in the
determination of inter-molecular free-length present in the investigated solutions by making use of ultrasonic approach.
Design, Synthesis and Molecular Docking Studies of Novel Pyrazole
Benzimidazole Derivatives as Potent Antibacterial Agents
Authors: Dasari Srinivasa Rao , Tondepu Subbaiah , Vadali Lakshmana Rao , Seelam Nareshvarma
Published: November 2019

A novel series of pyrazole benzimidazole derivatives were synthesized and the structure of the final targets 4a-h were confirmed by IR, Mass, 13C NMR and 1H NMR spectral analysis. The new pyrazole core with imidazole and benzimidazoles derivatives were evaluated for in vitro antibacterial, antifungal activity against six bacterial strains significantly. In dispersion, 4c, 4f and 4g had the highest antibacterial activities on these microorganisms Bacillus subtilis B29, Escherichia coli E266, with zone of inhibition
21, 19 and 19 mm, respectively. Compounds 4a, 4c, 4h shows good antifungal activity against A. niger, Fusarium oxysporum fungal strains. Further, molecular docking for protein ligands interactions was performed using the crystal structure of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-700. Among the final compounds 4e, 4g and 4h show highest binding energy ΔG = -7.89, -7.48 and -7.08 Kcal/mol, respectively and amino acid interactions Lys273, Asp27.
Synthesis of Metal-Polymer-Semiconductor Diode Using Polyaniline by Chemical Oxidative Method and its Temperature Dependent Electrical Conductivity Behaviour
Authors: Shoba E. , Pasupathy N. , Thirunavukkarasu P. , Chandrasekaran J. , Parthasarathy G.
Published: November 2019

The interfacial layer of pristine polyaniline (PANI) polymer was prepared using chemical oxidative method with 0.2 M concentration formerly, aniline hydrochloride was oxidized with ammonium peroxydisulfate 0.25 M in aqueous medium at 1-2 ºC next to aniline, stirring time and polymerization temperature are considerable causing parameters of polymerization reaction, harmoniously metal polymer- semiconductor (MPS) constructions of Cu/PANI/n-Si Schottky barrier diodes with different acids (HCl, acetic acid, nitric acid and sulfuric acid) was fabricated. The structural analyses of XRD sizes of the elements revealed that the crystal structure of distortion and converted into amorphous nature and SEM revealed that the morphology of pristine PANI powders. The FT-IR spectra confirmed that ammonium peroxydisulfate with pristine PANI along with band formation. The optical property of PANI was analyzed using UV-vis spectra and deliberate with minimum band gap 3.1 eV by means of HCl. The electrical property I -V temperature ranges 30 to 120 ºC represents that the maximum average conductivity obtains as 0.70 × 10-2 S/cm for 0.2 M HCl. The lowest ideality factor (n) and minimum barrier height (ΦB) values were achieved for HCl of Cu/PANI/n-Si Schottky barrier diode (SBDs) under the explanation disorder.
A Novel Synthesis, Characterization and Biological Studies of Ferrocenyl Substituted Pyrazoles
Authors: Kumar Manoj , Sharma Shashi , Tuli Hardeep Singh , Khare Rajshree
Published: November 2019

It has been discovered that ferrocenyl substituted heterocyclic compounds have wide scope of restorative methodology. The combination of ferrocenyl substituted pyrazole is the new class in these compounds with upgraded natural activity. This work center around blend of ferrocenyl substituted pyrazoles through novel course. The combination of 1-phenyl-3-ferrocenyl-pyrazole was examined including addition-cyclocondensation like response conditions. The response continued through three phases using of expansion cyclo-buildup of acetyl ferrocene with phenyl hydrazine pursued by cyclizing reagent iodine with NaHCO3. In both syntheses, each time single product isolated having good yields (87 and 79 %). Ferrocenyl substituted pyrazoles were examined by spectroscopic techniques (1H NMR, IR, MS) and their biological properties have been screened.
Comparative Spectroscopic Studies on Flotation Rate of Low Toxic Mixed Solvents
Authors: Hou Yanmin , Zhao Xiaojun
Published: November 2019

The application of hydrophilic mixed solvents provides a new direction for the study of green air flotation technology. In this test, a mixture of n-propanol and anhydrous ethanol (4:1) was selected as solvent, sodium chloride as phase separator, sodium hydroxide solution was used to maintain acidity and hydrophobic associations formed by Fe(III) and doxycycline were flotated to the organic phase. After flotation, the hydrophobic associations were analyzed by spectrophotometry and high performance liquid chromatography. The results showed that the hydrophilic mixed solvent maintained good flotation rate without toxicity
Displacement of Sodium, Potassium, Calcium, Magnesium and
Improvements in a Saline Soil Treated with Organic and Chemical Amendments
Authors: Trejo-González Nallely , Prieto-Méndez Judith , Marmolejo-Santillán Yolanda , Acevedo-Sandoval Otilio A. , Madariaga-Navarrete Alfredo , Aquino-Torres Eliazar , Canales-Flores Roberto A. , Prieto-García Francisco
Published: November 2019

The accumulation of salts in the soil produces conditions that affect the growth of most crops. Currently, soil amendments have been used to improve the texture and chemical & biological reactions of the soil. The objective of this work was to simulate the transport of sodium, potassium, calcium and magnesium in columns of saline soil through the use of organic and chemical amendments. Saline soil samples of the municipality of Tlahuelilpan, Hidalgo state, Mexico were studied. Compost, vermicompost, phosphogypsum and malting barley husk were used as amendments. The results showed that the highest metal element removal was obtained with the combined treatment of vermicompost at 4 % and phosphogypsum at 2 % (V4FY2) (59 %). Improvements in soil physico-chemical properties were also observed. These findings indicated that the combination of organic and chemical amendments promotes the leaching of metals, (mainly sodium). Therefore, the amendments evaluated in this study can be a good alternative for the remediation and improvement of saline soils.
Nanoemulsion of Sesame Seeds Oil: Preparation, Evaluation and Stability
Authors: El-Refai A.A. , Rabie M.M. , El-Gammal Rania E. , Al-Saban W.A.
Published: November 2019

This work aims to study the effect of using nanoemulsion particles on the stability of sesame seed oil emulsion. During the roasting process of sesame seeds (Sohage-1), some physico-chemical properties of sesame seeds and its oil were determined. The moisture, protein and fiber contents were decreased whereas oil, ash and arbohydrates contents were increased. Sesame oil was extracted from roasted sesame seeds using mechanical pressing; some physico-chemical properties for extracted oil were
determined. Results indicated that colour, acid value, free fatty acids (%), peroxide and hydrolysis values were increased, while saponification value was decreased in sesame oil. Also traditional and nanoemulsions form of sesame oil were prepared. Characterization of these emulsions particles was conducted using zeta potential and transmission electron microscope (TEM). The results also indicated that small droplet size of nanoemulsion particles being 26.28 nm in emulsion which prepared by using
nano-technique as compared with those of 638.8 nm in traditional emulsion type and low polydispersity index (PDI) was nanoemulsion particles 0.266. This lead to more uniformity in droplet size thus could improve the stability of emulsion system. The TEM results of nanoemulsion particles of sesame oil showed that spherical droplets and nearly similarity in shape in nanoemulsion in compared with semi-spherical and varied particles size in traditional one. Creaming index, centrifugation test, conductivity and freeze-thaw cycles were used to evaluate all type of prepared emulsion stability. The
nanoemulsion particles of sesame oil were found to be more stable than those of traditional one. These results indicated that the nanoemulsion process could increase the stability of prepared emulsion. Thus, using of nanoemulsion technique could be used as commercial way to enhance the stability of prepared emulsion.
Green Synthesis of Silver Nanoparticles using Salacca zalacca
Extract as Reducing Agent and It’s Antibacterial Activity
Authors: Prodjosantoso Anti Kolonial , Prawoko Oktanio Sigit , Utomo Maximus Pranjoto , Sari Lis Permana
Published: November 2019

In this article, the synthesis of silver nanoparticles through a reduction reaction process using Salacca zalacca extract is reported. The AgNPs were characterized using X-ray diffraction, transmission electron microscopy, Fourier transform infrared and UV-visible spectrophotometry methods. The AgNPs antibacterial activity was determined against of Gram-positive bacteria (Staphylococcus epidermidis) and Gram-negative bacteria (Escherichia coli). The main functional groups contained in Salacca zalacca extract are carbonyl, hydroxyl and nitrile groups, which are believed to reduce the silver ions to metal.
The surface plasmon resonance values of brownish red AgNPs are in the range of 410 nm to 460 nm. The structure of AgNPs is face centered cubic (FCC). The diameter of silver nanoparticles crystallite is 14.2 ± 2.6 nm. The AgNPs growth inhibition zones of Escherichia coli and Staphylococcus epidermidis are 9.6 mm and 9.2 mm, respectively.
Synthesis of Molecularly Imprinted Polymer for the Removal of Melamine
Authors: Roland Rachel Marcella , Bhawani Showkat Ahmad
Published: November 2019

In this article, molecularly imprinted polymer (MIP) of melamine was synthesized by non-covalent approach using microemulsion medium. In this study, melamine is used as a template molecule, acrylic acid as a functional monomer, N,N′-methylenebis(acrylamide) (MBAm) as a cross-linker and 2,2′-azobisisobutyronitrile (AIBN) as an initiator and microemulsion as a solvent. The produced polymers were characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) and thermogravimetric analysis (TGA). The batch
binding analysis was conducted for the evaluation of MIP and NIP rebinding efficiency with the melamine template. The adsorption studies including the adsorbent dosage of polymer, initial concentrations and pH of melamine solution were successfully carried out on both MIP and NIP. For selectivity test, 2,4,6-trichlorophenol was chosen as the competitive molecule against melamine template. A very good relative selectivity coefficient was achieved. The removal of melamine from different samples were conducted successfully by achieving a good removal efficiency in milk, river water and human blood serum 84.30, 94.26 and 93.32 %, respectively.
Synthesis and Biological Evaluation of Some Novel Mannich
Bases of Isoxazoline Derivatives as Possible Antimicrobial Agents
Authors: Gosavi Seema A. , Nandal Dattatray H. , Pawar Sarita S.
Published: November 2019

Novel isoxazoline derivatives were synthesized by condensation of substituted acetophenones with aldehyde in presence of alcoholic NaOH to get intermediate chalcones, which were further treated with hydroxylamine hydrochloride in presence of sodium hydroxide to get isoxazoline derivatives. The latter were refluxed separately with isonicotinic acid hydrazide and sulphanilamide in presence of formaldehyde for 6-10 h to afford corresponding Mannich bases. The structures of synthesized compounds were established on the basis of melting point, TLC, IR, 1H NMR and HRMS. Antimycobacterial activity of compounds (3a-j) were assessed against M. tuberculosis (vaccine strain,
H37 Rv strain) ATCC27294 using microplate Alamar Blue assay (MABA). Further the derivatives were evaluated for the antibacterial activity against Gram positive bacteria S. aureus (ATCC 9144), S. epidemidis (ATCC12228) and Gram negative bacteria E. coli (ATCC 25922), Klebsiella (ATCC 4352), while antifungal activity against A. flavus (ATCC 9643) and A. niger (ATCC 16404) by using agar well diffusion method using ciprofloxacin and fluconazole as standards, respectively. The results of antimicrobial studies showed that some of the derivatives posses mild to moderate biological activity as compared to standard.
Biosynthesis and Characterization of Bioplastic Poly-3-hydroxybutyrate from Hydrolyzate of Ulva using Bacillus subtilis rnM
Authors: Revadhi T. , Nanthini R.
Published: November 2019

Biopolymers are a new generation biopolymers, which have wide range of applications. Poly-3-hydroxybutyrate (PHB) is one of the best biopolymers for replacement of non-biodegradable petroleum-based plastic and can be produced from organic wastes source by some bacterial strains under imbalance growth conditions. In present study, hydrolyzate was prepared from biomass of seaweed Ulva by acid pre-treated and used as a feedstock for PHB biosynthesis by Bacillu subtilis rnM. The pre-treatment was carried out by two different pre-treatment conditions such as room temperature and high temperature and pressure (HTP). The hydrolysate prepared by 2 % HCl at HTP supported for the maximum PHB biosynthesis than the other pre-treated conditions. The yield of PHB obtained by B. subtilis rnM when tested with laboratory grade sugars was lower to that achieved with hydrolysate of Ulva sp. The biosynthesized PHB was characterized by TGA, DSC, FTIR, XRD and NMR techniques.
Dilithium Tetrachloromanganate an Effective Reagent for
Regioselective Ring Opening of Epoxides with Grignard Reagents
Authors: Devkate Santosh S. , Burungale Arvind S. , Pise Ashok S.
Published: November 2019

The epoxides were obtained from substituted phenols and epichlorohydrin by reported methods. The regioselective ring opening of epoxides were studied in different solvents by reaction with Grignard’s reagent in presence of dilithium tetrachloromanganate.
Design, Synthesis, Computational and Biological Evaluation of 4-Amino-3,5-dimercapto-1,2,4-triazole Surface Functionalized Gold Nanoparticles
Authors: Veena V. , Shivaprasad K.H. , Lokesh K.S. , Sharanagouda H. , Ramakrishna D.
Published: November 2019

Gold nanoparticles (AuNPs) are an obvious choice for rapid advance in nanotechnology due to their amenability of synthesis, functionalization and less toxicity. Functionalization of AuNP surface with 4-amino-3,5-dimercapto-1,2,4-triazole (ADMT) ligand as ADMT-AuNPs was investigated with the aim to probe the suitability of innovative product to develop new antibacterial and anticancer strategies. Various characterization studies like UV-spectra, Zeta size, Zeta potential, XRD, SEM, TEM and FTIR results of AuNPs and ADMT-AuNPs have been performed to study the structural and electronic properties. The studies revealed that the functionalized nanoparticles are highly crystalline in nature with the sizes ranging between 20-22 and 50-55 nm for AuNPs and ADMT-AuNPs, respectively with FCC structures. The characterization data reveals that the synthesized nanoparticles are stable and presence of strong interactions between the metallic surface and the organic ligand. Further, ADMT-AuNPs showed good antibacterial activity against Gram-positive and Gram-negative bacteria. MTT assay exhibited the cell viability with an IC50 value of 45.32 % v/v for ADMT-AuNPs against breast adenocarcinoma (MCF-7) cell lines. Molecular characterization i.e., in silico docking analysis helped in identifying and organizing the structural similarity/diversity at the molecular level. The in silico study indicated that the structure S1a has good glide score and glide energy for H-bonding among the possible conformations against bacterial and breast cancer protein. Molecular docking studies confirmed the introduction of conformational changes that are essential to surpass the potential energy barriers of ADMT-AuNPs for biocompatibility and proved that they hold a promising future in the medical field.
Facile Green Synthesis and Biological Activities of Silver Nanoparticles using Coldenia procumbens Linn.
Authors: Usha Rani G. , Rao B. Kesava , Bhanu P. Asha , Swapna G.
Published: November 2019

The facile green synthesis of silver nanoparticles is finding an imperative use in different fields due to their potential applications. The present study is focused on the green synthesis of silver nanoparticles from Coldenia procumbens Linn., in an eco-friendly way in order to reduce the toxicity from chemical methods. The zeta potential, size of the silver nanoparticles was measured and the characterization was done from UV-visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy. The disc diffusion method has used to evaluate the antimicrobial
efficacy of synthesized nanoparticles with different bacterial pathogens and the antioxidant capability of silver nanoparticles was tested and has shown significant DPPH radical scavenging activity.
Kinetics of Hydrogenation of Acetic Acid to Ethanol
Authors: Chen Qiang , Zhang Xuebing , Tian Shuxun , Long Junying , Meng Xiangkun , Sun Qi , Li Yonglong
Published: November 2019

The intrinsic kinetic behaviour of catalytic hydrogenation of acetic acid in vapour phase was studied over a multi-metallic catalyst. The rate expression was derived from the sequence of elementary reaction steps based on a Langmuir-Hinshelwood-model involving two types of active sites. Experiments were carried out in a fixed bed reactor, which is similar to an isothermal integral reactor designed to excluding the negative effects of internal and external diffusion. The reaction conditions investigated were as
follow:reaction temperature 275-325 ºC, reaction pressure1.5-3.0 MPa, liquid hourly space velocity (sv) 0.3-1.2 h-1, molar ratio of hydrogen to acetic acid (H/AC) 8:20. The results show that conversion of acetic acid increases with increasing the reaction temperature and pressure, but decreases with increasing the space velocity and H/AC. Furthermore, reducing the reaction pressure and increasing reaction temperature, space velocity and H/AC can improve the reaction selectivity of acetic acid to ethanol. The established kinetic model results agreed with experimental results. The relative difference between the calculated value and the experimental value is less than 6 %. The values of model parameters are consistent with the three thermodynamic constraints. The study provided evidence that the intrinsic kinetic model is suitable both mathematically and thermodynamically, and it could be useful in guiding reactor design and optimization of operating conditions.
Performance of Saccharomyces cerevisiae Strains to Ferment Sugarcane Juice
Authors: Patil Pallavi S. , Deshannavar Umesh B.
Published: November 2019

In the present study, four Saccharomyces cerevisiae strains S. cerevisiae (NCIM 3200), S. cerevisiae (NCIM 3045), S. cerevisiae (baker′s yeast) and S. cerevisiae (EC1118) have been used and compared for their capability to ferment sugars from the juice of sugarcane (of variety CO 86032) for production of sugarcane wine. The growth pattern of each strain was studied followed by the fermentation at optimized conditions such as pH and temperature. The strains′ potential to produce sugarcane wine has been compared in terms of their sugar consumption, alcohol production, titrable acidity and volatile acidity production with respect to permissible amounts given by Indian Regulations. Saccharomyces cerevisiae (EC1118) performed better in fermentation among other compared Saccharomyces strains at the optimum temperature of 28 ºC, optimum pH 5, total soluble solids of 18 ºBrix and total sugar content of 185 g/L. Analysis of sugarcane wine fermented by Saccharomyces cerevisiae (EC1118) has pH, 3.57, total alcohol content, 13.55 ± 1.77 %, titrable acidity, 8.30 ± 0.01 g/L and volatile acidity, 0.84 ± 0.00 g/L. The overall acceptability from sensory analysis supports the above physico-chemical analysis results of sugarcane wine.
A Flavone Fluorescent Probe for Cysteine Detection
Authors: Al-Busafi Saleh N. , Al-Kindi Salma M. , O. Suliman Fakhr Eldin , Al-Kalbani Aliya A.
Published: November 2019

A new blue-emitting fluorescent probe 1 based on flavone structure was prepared for the selective detection of cysteine. The probe was prepared through three synthetic steps from commercially available starting materials. Selective detection of cysteine by probe 1 in the presence of other non-thiol amino acids was established by UV-visible and fluorescent experiments. A remarkable fluorescence emission was observed at 469 nm when cysteine was mixed with probe 1. The Michael addition reaction of cysteine to probe-1 was confirmed by 1H NMR technique.
Suzuki Reaction for the Synthesis of New Derivatives of
4-Chloro-3,5-Dimethyl Phenol and their in vitro Antibacterial Screening
Authors: Zaooli R.H. , Hussein F.A. , Jafar N.N.A. , Al-Thamir S.N.K.
Published: November 2019

Many derivatives of 4-chloro-3,5-dimethylphenol have been synthesized using Suzuki reaction and characterized by IR, 1H NMR and micro elemental analysis. These compounds also tested in terms of their antibacterial properties against Staphylococcus aureus, Escherichia coli and Proteus mirabilis.