bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic Accuracy of Bone Turnover Markers as a Screening Tool for Aseptic Loosening after Total Hip Arthroplasty
Authors: Lawrence Neil R. , Jayasuriya Raveen L. , Gossiel Fatma , Wilkinson J. Mark
Published: June 2015

Aseptic loosening is the most common cause of prosthesis failure after total hip arthroplasty (THA). We measured serum cross-linked carboxyterminal telopeptide of type I collagen (ICTP), tartrate-resistant acid phosphatase 5b (TRAP5b), dickkopf-1 (dkk-1) and sclerostin; and urinary α isomer of C-terminal cross-linked telopeptide of type I collagen (αCTX-I) to investigate their potential diagnostic value detecting aseptic loosening after THA. Biomarkers were measured in 24 subjects with aseptic loosening of THA versus 26 control subjects without loosening after THA. Serum ICTP in the loose group (7.04 ng/mL) was higher than controls (5.15 ng/mL), (p = 0.0007). ROC analysis demonstrated that a serum ICTP >5.5 ng/L had a sensitivity of 91% and specificity of 69% for detecting aseptic loosening (area under ROC curve = 0.77, p = 0.0001), resulting in a positive predictive value (PPV) of 73% and a negative predictive value (NPV) of 90%. Serum TRAP5b in the aseptic loosening group (4.17U/L) was higher than controls (3.44 U/L), (p = 0.03). A serum TRAP5b >2.46 U/L had sensitivity of 100% and a specificity of 31% to detect aseptic loosening (AUC 0.67, p = 0.031), resulting in a PPV of 57% and a NPV of 100%. Serum dkk-1, serum sclerostin and urinary αCTX-I were not elevated in subjects with aseptic loosening (p>0.05).

Serum ICTP and TRAP5b show potential utility as screening biomarkers for excluding aseptic loosening, because of their ability to discriminate individuals without disease. Our finding of elevated ICTP, generated by the action of matrix metalloproteinases, suggests a role for this group of endopeptidases in aseptic loosening.
New Cementless Fixation in Hip Arthroplasty: A Radiostereometric Analysis
Authors: Matejcic Aljosa , Vidovic Dinko , Nebergall Audrey , Greene Meridith , Bresina Stephen , Tepic Slobodan , Malchau Henrik , Hodge William A.
Published: June 2015

Introduction

Scyon Orthopaedics AG developed a new mode of cementless fixation of the femoral component that provides immediate and permanent anchorage by monocortical locking screws. The aim of this study was to evaluate the stability of the Scyon total hip replacement (THR) stem in-vivo.

Methods

A total of 15 patients, with an average age of 50 years had surgery between 2008 and 2011. Each patient received a Scyon THR. Standard questionnaires were completed at each follow-up visit for evaluation of functional outcomes. RSA, patient reported outcomes, and plain radiographic follow-up were obtained at 6 months, 1 year, 2 years, and 5 years postoperatively.

Results

The median ± standard error (SE) stem subsidence (negative y-translation) was 0.07 ± 0.07 mm at 1 year, 0.05 ± 0.04 mm at 2 years and 0.04 ± 0.13 mm at 5 years. The median ± SE stem rotation (y-rotation) was 0.1 ± 0.21 degrees at 1 year, 0.51 ± 0.31 degrees at 2 years and 0.60 ± 0.37 degrees at 5 years. Plain radiographs showed bone on-growth onto medial aspect of the stem. Median HHS improved from 55 preoperatively to 93 at 1 year and 97 at 5 years. The median UCLA Activity Score improved from 4 preoperatively to 6 at 1 year and 5 years.

Conclusions

RSA results indicate that the Scyon stem with its 5 monocortical locking screws is stable at 5 years. Immediate surgical fixation of the stem and bony on-growth onto the femoral component may ultimately decrease the rate of aseptic stem loosening in these THR patients.
Immunological Status of Chronic Myelogenous Leukemia Patients with Complete Cytogenetic Response after Treatment
Authors: Deng Zhikui , Li Yuanyuan , Li Yu-feng
Published: June 2015

Background

The aim of this study was to compare the T lymphocyte subsets of chronic myelogenous leukemia (CML) patients who had a complete cytogenetic response (CCyR) after treatment with imatinib (IM) or homoharringtonine (HHT).

Methods

T and Th lymphocyte subsets in CCyR patients treated with HHT (n = 15) or IM (n = 16) were assayed with flow cytometry.

Results

It was found that there were no differences in T lymphocyte subset proportions at the time of achieving CCyR0 and also no difference in the CD8+T cell proportions at the 12th month after CCyR (CCyR12), between the 2 groups. The values of CD3+T, CD4+T, CD8+T, CD4+T/CD8+T, Th1 and Th2 cells were 54.21% ± 6.12% vs. 44.32% ± 4.85%, 29.83% ± 5.53% vs. 22.27% ± 3.22%, 24.66 ± 4.91 vs. 25.41% ± 5.72%, 1.11 ± 0.23 vs. 0.92 ± 0.19, 10.23% ± 4.24% vs. 8.34% ± 3.45% and 11.12% ± 3.91% vs. 13.67% ± 4.78%, respectively in the HHT group and IM group at CCyR12, which meant that the proportions of CD3+T, CD4+T and Th1 cells and the ratio of CD4+T to CD8+T cells were higher and the CD8+T and Th2 cell proportions were lower in the HHT group than in the IM group.

Conclusions

HHT has a weaker immunodepression effect on T lymphocyte subsets compared with IM.
Role of HER Family Members in Predicting Prognoses in Epithelial Ovarian Cancer: A Meta-analysis
Authors: Ouyang Weixiang , Xu Linjuan , Huang Zaiju , Guo Jianfeng , Cai Jing , Gao Xuejiao , Wang Zehua
Published: June 2015

Aims and Background

Human epidermal receptor (HER) family receptors are commonly overexpressed in various human tumors, and their overexpression is thought to play a critical role in tumor progression. The aim of this meta-analysis was to evaluate the prognostic significance of HER family members in epithelial ovarian cancer (EOC).

Methods

Relevant studies published between January 1, 1980, and April 24, 2013, that evaluated the associations of HER family members with overall survival (OS), progression-free survival (PFS), response to platinum-based chemotherapy, lymph node metastasis, or ascites in EOC were identified via searches of PubMed and EMBASE.

Results

We identified 37 eligible articles that met the inclusion criteria. The results of the meta-analysis revealed that significantly poorer OS of patients with EOC was predicted by high Her-2 expression levels (hazard ratio [HR] 1.69, 95% confidence interval [CI] 1.31-2.19). Furthermore, high Her-2 expression was significantly associated with poor PFS (HR 1.88, 95% CI 1.46-2.41) and an increased risk of ascites (risk ratio 1.21, 95% CI 1.02-1.42).

Conclusions

High levels of expression of Her-2 are significantly related to poor survival and an increased risk of ascites in patients with EOC. Future prospective cohorts with larger samples are needed to verify the prognostic value of Her-2 expression in EOC.
Quality of Life and Pain Control following Laparoscopic Retroperitoneal Lymph Node Dissection in Early-stage Nonseminoma
Authors: Nicolai Nicola , Bianchi Elisabetta , Donati Ilaria , L'Acqua Camilla , Brunelli Cinzia , Biasoni Davide , Catanzaro Mario , Stagni Silvia , Piva Luigi , Torelli Tullio , Necchi Andrea , Raggi Daniele , Giannatempo Patrizia , Faré Elena , Colecchia Maurizio , Langer Martin , Borreani Claudia , Salvioni Roberto
Published: June 2015

Aims and Background

To evaluate postoperative pain (PoP) and quality of life (QoL) in patients undergoing open (O-) or laparoscopic (L-) retroperitoneal lymph node dissection (RPLND) for clinical stage I (CS I) and normal markers CS IIA nonseminomatous germ cell tumors.

Methods

Since March 2010, a prospective nonrandomized trial evaluated dynamic and rest (R) numeric pain scale (NPS) following patient-controlled analgesia and baseline (T0), 3-month (T3), and 6-month (T6) QoL status assessed by Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire and the Italian-validated Functional Assessment of Chronic Illness Therapy (FACT-T-SG) at T6. Secondary endpoints included length of hospital stay (LHS), interval to recovery (ItR), complications, and oncologic outcomes.

Results

In March 2012, 69 (64 CS I) patients were enrolled. Five patients only chose O-RPLND. The PoP and complete QoL data are available in 41 and 56 patients, respectively. The R-NPS significantly improved in days 1-2 vs day 0 (p<0.0008). The FACT-G scores improved from baseline: the emotional well-being scale was the most relevant at T3 (+7.0, p = 0.0001) and T6 (+6.9, p = 0.0002). The FACT-TS-G indicated high satisfaction levels. Median LHS and ItR were 3 and 15 days. Six complications required an intervention. Nodal metastases were found in 14 (20.3%) patients. Following a median follow-up of 36 months, 6 (8.9%) patients relapsed (2/12 among pN+), and 8 patients (11.9%) underwent chemotherapy. All patients maintained antegrade ejaculation and are alive and disease-free.

Conclusions

Almost all patients chose L-RPLND, which is associated with a rapid improvement of postoperative pain; QoL scores improved up to 6 months. The L-RPLND may be considered as an alternative only when performed in highly experienced centers.
Hope in Cancer Patients: The Relational Domain as a Crucial Factor
Authors: Proserpio Tullio , Ferrari Andrea , Vullo Salvatore Lo , Massimino Maura , Clerici Carlo Alfredo , Veneroni Laura , Bresciani Carlo , Casali Paolo G. , Ferrari Mauro , Bossi Paolo , Galmozzi Gustavo , Pierantozzi Andrea , Licitra Lisa , Marceglia Sara , Mariani Luigi
Published: June 2015

Aims and background

Hope is crucial for patients with cancer. We explored the determinants of hope in patients with cancer using a questionnaire administered over the course of 1 day to an unselected sample of patients at an Italian cancer center.

Methods

A team of oncologists, statisticians, and chaplains developed a questionnaire with medical, psychological, spiritual, and religious content. A cross-sectional study was conducted on 320 patients who answered the questionnaire.

Results

In the group of participants, 92.8% had a religious belief. Women, patients with limited formal education, and believers were more hopeful. Patients placed trust in God, their partners and children, scientific research, and doctors. On univariate and multivariate analysis, hope was found sensitive to patients' sharing their experiences with others (including family and friends), their positive perception of the people around them, and their relationship with doctors and nurses.

Conclusions

If validated in further studies, these results support the notion that a patient with cancer's sense of hope is sensitive to the quality of relationships with caregivers. This may be important to health care organization and resource allocation.
Congruence-Association Model and Experiments in Film Music: Toward Interdisciplinary Collaboration
Authors: Cohen Annabel J.
Published: June 2015

The article draws attention to the value of objective measurement of both human responses and soundtracks for validating conjectures about the role of film music. Based on empirical research on film music as well as ideas from film theory and cognitive science, the author’s Congruence-Association Model with Working Narrative (CAM-WN) is introduced as a means for organizing ideas about the role of music in film. The application of CAM-WN to the problem of unattended film music is reviewed, and the notion of subjective silence is examined in the context of spectrographic representation of film music. While empirical research with human participants is also encouraged, the complexity of the enterprise is highlighted by a list of questions to consider in advance. Interdisciplinary collaboration is suggested as a means for overcoming the complexity of film-music behavioral research, though it is not a panacea. The Lund University Film Studies Department offers an important example in this direction.
Deconstructing Incongruence: A Psycho-semiotic Approach toward Difference in the Film-Music Relationship
Authors: Ireland David
Published: June 2015

This article summarizes the incongruent perspective, a psycho-semiotic approach toward the study of film-music difference that is contextualized by poststructuralist thought. Examples are cited from empirical research conducted alongside the initial theoretical deconstruction to demonstrate the following: how the perspective theorizes various levels of film-music difference, and their impact upon perceiver experience and response; and the ways in which empirical studies can facilitate inter- and multidisciplinary conceptual deconstruction.
Le néoconservatisme canadien
Authors: Dorion-Soulié Manuel , Sanschagrin David
Published: June 2015

Existe-t-il un néoconservatisme canadien ? De nombreux analystes de politique étrangère canadienne utilisent ce terme pour décrire le gouvernement Harper et l’« école de Calgary », sans toutefois conceptualiser précisément l’objet politique dont il est question. Certains affirment même qu’il s’agit d’une idéologie importée des États-Unis. Cet article montre d’abord la « reconnaissance » que les néoconservateurs américains accordent à leurs homologues canadiens, et vice versa, illustrant ainsi la proximité idéologique entre les deux néoconservatismes. Cependant, dans la deuxième portion de l’article est proposée une définition générique du néoconservatisme, montrant que, s’il est juste de parler de néoconservatisme pour décrire Harper et l’« école de Calgary », il ne faut pas y voir une influence américaine. Le néoconservatisme canadien a ses particularités et sa tradition propres.
La politique iranienne du Canada
Authors: Dumas Philippe
Published: June 2015

L'élection du gouvernement Harper a généré une réflexion chez les chercheurs étudiant la politique étrangère canadienne. Leurs constats oscillant toujours entre continuité et rupture, d’autres contributions sont de mise afin d’alimenter le débat. Cet article répondra à la question suivante : La politique iranienne du Canada, telle qu’elle est formulée et mise en oeuvre, est-elle la manifestation d’une culture stratégique néocontinentaliste ? Cette proposition quant à l’émergence d’une vision néocontinentaliste sera mise à l’épreuve au regard de la politique iranienne du Canada. Évoquée par ce gouvernement comme un élément important de sa politique étrangère, la politique iranienne du Canada n’a été que très peu analysée jusqu’à aujourd’hui.
Le rôle de la gouvernance des clusters dans les capacités dynamiques d’absorption des PME
Authors: Bocquet Rachel , Mothe Caroline
Published: June 2015

En combinant laKnowledge-Based View of Clusterset l’approche basée sur les capacités dynamiques, notre objectif est d’identifier la manière dont la structure de gouvernance d’un cluster peut accroître les capacités dynamiques d’absorption des entreprises membres. Une étude qualitative longitudinale auprès des membres de la gouvernance d’un pôle de compétitivité français à dominante PME montre le rôle clé de l’implication à la fois directe de la structure de gouvernance dans les actions individuelles et collectives, et indirecte en tant qu’intermédiaire entre les entreprises et les expertises utiles. Ce modèle original de management « intermédié » des connaissances présente d’importantes implications managériales.
Analysis of source characteristics of experimental gas burst and fragmentation explosions generated by rapid decompression of volcanic rocks
Authors: Arciniega‐Ceballos A. , Alatorre‐Ibargüengoitia M. , Scheu B. , Dingwell D. B.
Published: June 2015

Gas burst and fragmentation explosions induced by rapid decompression of volcanic rocks in a high‐pressure autoclave have been analyzed. We performed experiments from 4 to 20 MPa on (1) loose pyroclasts and (2) pumice from recent eruptions of Popocatépetl volcano. Our aim is to characterize the source mechanism distinguishing the physical processes that operate in the conduit which determine the dynamics of explosive volcanoes. For this aim we have analyzed experimentally the parameters that indicate the state and behavior of the conduit (i.e., decompression time, fragmentation threshold and speed, forces, and the partitioning of energy), using microseismic monitoring, the decompression time curves, and the sample rheological properties. The initial available potential energy in the system and its partitioning into different types of energies are correlated in space and time with specific stages of the explosive phenomenon. Such correlations, taken together with the energy distribution, enable the distinction of the individual physical processes involved and their causal sequence and relationships. Our observations suggest that in volcanic conduits with regular explosive activity, a source mechanism may operate whereby a causal sequence of processes results in a system that undergoes both rapid and stable transitions. Such behavior may persist over long periods of time.
Semiautomatic fracture zone tracking
Authors: Wessel Paul , Matthews Kara J. , Müller R. Dietmar , Mazzoni Aline , Whittaker Joanne M. , Myhill Robert , Chandler Michael T.
Published: June 2015

Oceanic fracture zone traces are widely used in studies of seafloor morphology and plate kinematics. Satellite altimetry missions have resulted in high‐resolution gravity maps in which all major fracture zones and other tectonic fabric can be identified, and numerous scientists have digitized such lineaments. We have initiated a community effort to maintain low‐cost infrastructure that allows seafloor fabric lineaments to be stored, accessed, and updated. A key improvement over past efforts is our processing software (released as a GMT5 supplement) that allows for semiautomatic corrections to previously digitized fracture zone traces given improved gridded data sets. Here we report on our seafloor fabric processing tools, which complement our database of seafloor fabric lineations, magnetic anomaly identifications, and plate kinematic models.
Strain Tuning and Strong Enhancement of Ionic Conductivity in SrZrO3–RE2O3 (RE = Sm, Eu, Gd, Dy, and Er) Nanocomposite Films
Authors: Lee Shinbuhm , Zhang Wenrui , Khatkhatay Fauzia , Jia Quanxi , Wang Haiyan , MacManus‐Driscoll Judith L.
Published: June 2015

Fast ion transport channels at interfaces in thin films have attracted great attention due to a range of potential applications for energy materials and devices, for, solid oxide fuel cells, sensors, and memories. Here, it is shown that in vertical nanocomposite heteroepitaxial films of SrZrO3–RE2O3 (RE = Sm, Eu, Gd, Dy, and Er) the ionic conductivity of the composite can be tuned and strongly enhanced using embedded, stiff, and vertical nanopillars of RE2O3. With increasing lattice constant of RE2O3 from Er2O3 to Sm2O3, it is found that the tensile strain in the SrZrO3 increases proportionately, and the ionic conductivity of the composite increases accordingly, by an order of magnitude. The results here conclusively show, for the first time, that strain in films can be effectively used to tune the ionic conductivity of the materials.
Terahertz Broadband Low‐Reflection Metasurface by Controlling Phase Distributions
Authors: Dong Di Sha , Yang Jing , Cheng Qiang , Zhao Jie , Gao Li Hua , Ma Shao Jie , Liu Shuo , Chen Hai Bin , He Qiong , Liu Wei Wei , Fang Zheyu , Zhou Lei , Cui Tie Jun
Published: June 2015

Recently, reflectionless or low‐reflection surfaces made of subwavelength structures have been of broad interest in practical engineering. Here, a single‐layer terahertz metasurface is proposed to produce ultralow reflections across a broad‐frequency spectrum and wide incidence angles by controlling the reflection phases of subwavelength structures. To enable full control of the phase range in a continuous band, a combination of two different subwavelength elements are employed, both of which exhibit weak interactions with the incident terahertz waves, thereby showing high local reflectivities near the operating frequency. An optimization method is utilized to determine the array pattern with the minimum overall reflections under the illumination of plane waves. Both numerical simulations and experimental results demonstrate ultralow reflections of terahertz waves by the metasurface over a broad frequency band and wide incidence angles. By using the proposed metasurface, the far‐field scattering patterns of metallic objects can be efficiently controlled, which opens up a new route for low‐reflection surface designs in the terahertz spectrum.
Experimental Study of the Extrusion Characteristic of a Vane Extruder Based on Extensional Flow
Authors: Xiaochun Yin , Sai Li , Guangjian He , Guizhen Zhang , Jinping Qu
Published: June 2015

Experiments were carried out to study the extrusion characteristics of a vane extruder based on extensional flow. The effects of rotor speed and die pressure on output were studied and compared with a single screw extruder. The responses of melt pressure to rotor speed and die pressure were also studied in real timescale. Experimental results show that the die pressure has little effect on output, which is significantly different from that of single screw extruders. Oscillation pressure was introduced into the extrusion process by the dynamic convergent–divergent flow channel of the vane extruder. The oscillation frequency of melt pressure is four times of that of the rotor angular frequency. The die pressure has a little influence on the oscillation amplitude of melt pressure. The oscillation amplitude of melt pressure increases with the increase of rotor speed. The oscillation amplitude of melt pressure decreases along the extrusion direction.
Charge‐Carrier Mobility Requirements for Bulk Heterojunction Solar Cells with High Fill Factor and External Quantum Efficiency >90%
Authors: Bartelt Jonathan A. , Lam David , Burke Timothy M. , Sweetnam Sean M. , McGehee Michael D.
Published: June 2015

To increase the efficiency of bulk heterojunction (BHJ) solar cells beyond 15%, 300 nm thick devices with 0.8 fill factor (FF) and external quantum efficiency (EQE) >90% are likely needed. This work demonstrates that numerical device simulators are a powerful tool for investigating charge‐carrier transport in BHJ devices and are useful for rapidly determining what semiconductor pro­perties are needed to reach these performance milestones. The electron and hole mobility in a BHJ must be ≈10−2 cm2 V−1 s−1 in order to attain a 0.8 FF in a 300 nm thick device with the recombination rate constant of poly(3‐hexyl­thiophene):[6,6]‐phenyl‐C61‐butyric acid methyl ester (P3HT:PCBM). Thus, the hole mobility of donor polymers needs to increase from ≈10−4 to ≈10−2 cm2 V−1 s−1 in order to significantly improve device performance. Furthermore, the charge‐carrier mobility required for high FF is directly proportional to the BHJ recombination rate constant, which demonstrates that decreasing the recombination rate constant could dramatically improve the efficiency of optically thick devices. These findings suggest that researchers should prioritize improving charge‐carrier mobility when synthesizing new materials for BHJ solar cells and highlight that they should aim to understand what factors affect the recombination rate constant in these devices.
Elucidation of Pathways for NO Electroreduction on Pt(111) from First Principles
Authors: Clayborne Andre , Chun Hee‐Joon , Rankin Rees B. , Greeley Jeff
Published: June 2015

The mechanism of nitric oxide electroreduction on Pt(111) is investigated using a combination of first principles calculations and electrokinetic rate theories. Barriers for chemical cleavage of NO bonds on Pt(111) are found to be inaccessibly high at room temperature, implying that explicit electrochemical steps, along with the aqueous environment, play important roles in the experimentally observed formation of ammonia. Use of explicit water models, and associated determination of potential‐dependent barriers based on Bulter–Volmer kinetics, demonstrate that ammonia is produced through a series of water‐assisted protonation and bond dissociation steps at modest voltages (<0.3 V). In addition, the analysis sheds light on the poorly understood formation mechanism of nitrous oxide (N2O) at higher potentials, which suggests that N2O is not produced through a Langmuir–Hinshelwood mechanism; rather, its formation is facilitated through an Eley–Rideal‐type process.
Encapsulation of Halocarbons in a Tetrahedral Anion Cage
Authors: Yang Dong , Zhao Jie , Zhao Yanxia , Lei Yibo , Cao Liping , Yang Xiao‐Juan , Davi Martin , de Sousa Amadeu Nader , Janiak Christoph , Zhang Zhibin , Wang Yao‐Yu , Wu Biao
Published: June 2015

Caged supramolecular systems are promising hosts for guest inclusion, separation, and stabilization. Well‐studied examples are mainly metal‐coordination‐based or covalent architectures. An anion‐coordination‐based cage that is capable of encapsulating halocarbon guests is reported for the first time. This A4L4‐type (A=anion) tetrahedral cage, [(PO4)4L4]12−, assembled from a C3‐symmetric tris(bisurea) ligand (L) and phosphate ion (PO43−), readily accommodates a series of quasi‐tetrahedral halocarbons, such as the Freon components CFCl3, CF2Cl2, CHFCl2, and C(CH3)F3, and chlorocarbons CH2Cl2, CHCl3, CCl4, C(CH3)Cl3, C(CH3)2Cl2, and C(CH3)3Cl. The guest encapsulation in the solid state is confirmed by crystal structures, while the host–guest interactions in solution were demonstrated by NMR techniques.
Enhancing information retrieval through concept‐based language modeling and semantic smoothing
Authors: Said Lhadj Lynda , Boughanem Mohand , Amrouche Karima
Published: June 2015

Traditionally, many information retrieval models assume that terms occur in documents independently. Although these models have already shown good performance, the word independency assumption seems to be unrealistic from a natural language point of view, which considers that terms are related to each other. Therefore, such an assumption leads to two well‐known problems in information retrieval (IR), namely, polysemy, or term mismatch, and synonymy. In language models, these issues have been addressed by considering dependencies such as bigrams, phrasal‐concepts, or word relationships, but such models are estimated using simple n‐grams or concept counting. In this paper, we address polysemy and synonymy mismatch with a concept‐based language modeling approach that combines ontological concepts from external resources with frequently found collocations from the document collection. In addition, the concept‐based model is enriched with subconcepts and semantic relationships through a semantic smoothing technique so as to perform semantic matching. Experiments carried out on TREC collections show that our model achieves significant improvements over a single word‐based model and the Markov Random Field model (using a Markov classifier).
Ibrutinib and rituximab induced rapid response in refractory Richter syndrome
Authors: Lamar Zanetta , Kennedy LeAnne , Kennedy Brooke , Lynch Mary , Goad Amanda , Hurd David , McIver Zachariah
Published: June 2015

Key Clinical Message

We report a 53‐year‐old man diagnosed with Richter syndrome. He was heavily pretreated and was refractory to prior therapy. He received rituximab and ibrutinib, and achieved a significant response after 1 month of therapy. Our case illustrates the importance of investigation of rituximab and ibrutinib in Richter's syndrome.
ChemInform Abstract: Crystal Structure of Bis(fluorosulfato‐ϰO)xenon(II), Xe(SO3F)2.
Authors: Malischewski Moritz , Seppelt Konrad
Published: June 2015

Thermally unstable Xe(SO3F)2 is prepared by reaction of XeF2 with HSO3F (sealed PFA tube, 273 K) and single crystals are obtained from HSO3F by slow cooling in the sealed tube to 193 K.
ChemInform Abstract: Structural Origin of the Anisotropic and Isotropic Thermal Expansion of K2NiF4‐Type LaSrAlO4 and Sr2TiO4.
Authors: Yashima Masatomo , et al.
Published: June 2015

The anisotropic and isotropic thermal expansion of LaSrAlO4 and Sr2TiO4, resp.
ChemInform Abstract: Facile Construction of Graphene‐Like Ni3S2 nanosheets Through the Hydrothermally Assisted Sulfurization of Nickel Foam and Their Application as Self‐Supported Electrodes for Supercapacitors.
Authors: Zhuo Ming , Zhang Ping , Chen Yuejiao , Li Qiuhong
Published: June 2015

Graphene‐like large‐area Ni3S2 nanosheets are obtained via hydrothermally assisted sulfurization of nickel foam in an aqueous solution of MeCSNH2 (autoclave, 120 °C, 4 h).
ChemInform Abstract: Sr2MgOsO6: A Frustrated Os6+(5d2) Double Perovskite with Strong Antiferromagnetic Interactions.
Authors: Sarapulova Angelina , Adler Peter , Schnelle Walter , Mikhailova Daria , Felser Claudia , Tjeng Liu Hao , Jansen Martin
Published: June 2015

The Os6+ (t2g2) double perovskite Sr2MgOsO6 is prepared by solid state reaction of stoichiometric amounts of SrO2, OsO2, and MgO under intermittent regrinding and final oxidation (1.
ChemInform Abstract: Electronic Pseudogap‐Driven Formation of New Double‐Perovskite‐Like Borides within the Sc2Ir6—xTxB (T: Pd, Ni; x: 0—6) Series.
Authors: Hermus Martin , Scheifers Jan P. , Touzani Rachid , Fokwa Boniface P. T.
Published: June 2015

DFT calculations for the ternary phases Sc2M6B (M: Ir, Pd, Ni) reveal the presence of pseudogaps near their Fermi levels between 61 and 68 valence electrons leading to the prediction of new phases Sc2Ir6‐xPdxB and Sc2Ir6‐xNixB (x = 0—6) in the double‐perovskite‐like Ti2Rh6B‐type structure.
ChemInform Abstract: Facile, Diversity‐Oriented, Normal‐Electron‐Demand Diels—Alder Reactions of 6‐Amino‐2H‐pyran‐2‐ones with Diethyl Acetylene‐dicarboxylate, 1,4‐Naphthoquinone, and N‐Phenylmaleimide.
Authors: Khatri Adil I. , Samant Shriniwas D.
Published: June 2015

The Diels—Alder reactions of the title dienophiles with pyranones (I) follow three different pathways to produce benzene, anthraquinone, and polycyclic diimide derivatives.
ChemInform Abstract: Rh‐Catalyzed C—C Bond Cleavage by Transfer Hydroformylation.
Authors: Murphy Stephen K. , Park Jung‐Woo , Cruz Faben A. , Dong Vy M.
Published: June 2015

This method uses strained olefins ‐ e.
ChemInform Abstract: Tandem Benzylic Oxidation/Dihydroxylation of α‐Vinyl‐ and α‐Alkenylbenzyl Alcohols.
Authors: Fernandes Rodney A. , Kattanguru Pullaiah
Published: June 2015

The method is substrate‐selective and specific for the oxidation of benzylic alcohols.
ChemInform Abstract: Enantioselective Construction of Tetrasubstituted Stereogenic Carbons Through Broensted Base Catalyzed Michael Reactions: α′‐Hydroxy Enones as Key Enoate Equivalent.
Authors: Palomo Claudio , et al.
Published: June 2015

α‐Hydroxy enones undergo asymmetric Michael reactions with a broad variety of Michael donors catalyzed by varying chiral catalysts.
ChemInform Abstract: Asymmetric Dual‐Reagent Catalysis: Mannich‐Type Reactions Catalyzed by Ion Pair.
Authors: Wang Hong‐Yu , Zhang Kai , Zheng Chang‐Wu , Chai Zhuo , Cao Dong‐Dong , Zhang Jia‐Xing , Zhao Gang
Published: June 2015

This method uses new bifunctional phosphines and methyl acrylate which in situ generate zwitterions serving as catalysts for asymmetric Mannich‐type and aza‐Henry reactions through a homogeneous ion‐pairing mode.
ChemInform Abstract: Metal‐Catalyzed Azidation of Tertiary C—H Bonds Suitable for Late‐Stage Functionalization.
Authors: Sharma Ankit , Hartwig John F.
Published: June 2015

The azidation occurs with high regioselectivity at the remote tertiary carbon of compounds (I).
ChemInform Abstract: Diastereoselective Nitroaldol Reaction Catalyzed by Binuclear Copper(II) Complexes in Aqueous Medium.
Authors: Arunachalam Rajendran , Aswathi Chirayil S. , Das Anjan , Kureshy Rukhsana I. , Subramanian Palani S.
Published: June 2015

Two polydentate ligands are incorporated to produce the Cu‐complexes (I) and (II).
ChemInform Abstract: C—H Activation Dependent Pd‐Catalyzed Carbonylative Coupling of (Hetero)aryl Bromides and Polyfluoroarenes.
Authors: Lian Zhong , Friis Stig D. , Skrydstrup Troels
Published: June 2015

This method uses a two chamber system allowing the reaction to run with near stoichiometric amounts of freshly generated CO.
ChemInform Abstract: Two‐Step Cyanomethylation Protocol: Convenient Access to Functionalized Aryl‐ and Heteroarylacetonitriles.
Authors: Lindsay‐Scott Peter J. , Clarke Aimee , Richardson Jeffery
Published: June 2015

A protocol for the coupling of potassium aryltrifluoroborate salts or heteroarylstannanes with a bromoisoxazole derivative is developed, and the products are deprotected under conventional or microwave‐assisted heating to form various aryl or hetarylacetonitriles, respectively.
ChemInform Abstract: Gold‐Catalyzed Hydroarylating Cyclization of 1,2‐Bis(2‐iodoethynyl)benzenes.
Authors: Noesel Pascal , Mueller Vanessa , Mader Steffen , Moghimi Setareh , Rudolph Matthias , Braun Ingo , Rominger Frank , Hashmi A. Stephen K.
Published: June 2015

The title reaction with benzene or electron rich arenes as reacting solvent produces aryl‐diiodonaphthalenes in good yields.
ChemInform Abstract: Tetracyclopenta[def,jkl,pqr,vwx]tetraphenylene: A Potential Tetraradicaloid Hydrocarbon.
Authors: Nobusue Shunpei , Miyoshi Hirokazu , Shimizu Akihiro , Hisaki Ichiro , Fukuda Kotaro , Nakano Masayoshi , Tobe Yoshito
Published: June 2015

Compound (I), a derivative of the hitherto unknown title compound which is a potential tetraradicaloid hydrocarbon, is synthesized in five steps starting from a known polycyclic tetracarboxylic acid (synthetic pathway not shown).
ChemInform Abstract: Enantioselective Assembly of Functionalized Carbocyclic Spirooxindoles Using an L‐Proline Derived Thiourea Organocatalyst.
Authors: Reddy Gajulapalli V. Pratap , Vinayagam Poopathy , Kesavan Venkitasamy
Published: June 2015

Multifunctional spirooxindole scaffolds are synthesized by enantioselective multi‐component reactions involving sequential vinylogous Michael addition and cyclization.
ChemInform Abstract: Type II Intramolecular [5 + 2] Cycloaddition: Facile Synthesis of Highly Functionalized Bridged Ring Systems.
Authors: Mei Guangjian , Liu Xin , Qiao Chuang , Chen Wei , Li Chuang‐chuang
Published: June 2015

The first type II intramolecular [5 + 2] cycloaddition reaction involving an oxopyrylium ylide and a simple alkene provides a range of bridged cycloheptenone derivatives.
ChemInform Abstract: Coupling of Carboxylic Acids with Internal Alkynes by Supported Ruthenium Catalysts: Direct and Selective Syntheses of Multi‐Substituted Phthalide Derivatives.
Authors: Miura Hiroki , Tsutsui Kentaro , Wada Kenji , Shishido Tetsuya
Published: June 2015

The applied catalyst can be recycled at least five times with no loss of activity.
ChemInform Abstract: Multicomponent One‐Pot Synthesis of Highly‐Functionalized Pyrrole‐3‐carbonitriles in Aqueous Medium and Their Computational Study.
Authors: Pagadala Ramakanth , Kommidi Devendar Reddy , Kankala Shravankumar , Maddila Suresh , Singh Parvesh , Moodley Brenda , Koorbanally N. A. , Jonnalagadda Sreekantha B.
Published: June 2015

A simple four‐component reaction of aldehydes, malononitrile, isocyanates and cyclic secondary amines yields fully substituted pyrroles by mild heating in water.
ChemInform Abstract: Oxidative Alkenylation/Annulation of Benzimidates via Ruthenium(II)‐Catalyzed C—H Activation to Generate 3‐Methyleneisoindolin‐1‐ones.
Authors: Li Xing Guang , Sun Min , Liu Kai , Liu Pei Nian
Published: June 2015

The N—H imidate group efficiently acts as a directing group in Ru‐catalyzed C—H activation allowing the regio‐ and stereoselective synthesis of methyleneisoindolinones.
ChemInform Abstract: 1,6‐Addition Reaction of 5H‐Oxazol‐4‐ones to Conjugated Dienones Catalyzed by Chiral Guanidines.
Authors: Morita Akane , Misaki Tomonori , Sugimura Takashi
Published: June 2015

The 1,6‐addition of 5H‐oxazolones to conjugated dienones catalyzed by chiral guanidines to yield oxazol derivatives is described.
ChemInform Abstract: 2‐Pyrrolecarbaldiminato—Cu(II) Complex Catalyzed Three‐Component 1,3‐Dipolar Cycloaddition for 1,4‐Disubstituted 1,2,3‐Triazoles Synthesis in Water at Room Temperature.
Authors: Zhou Changjian , Zhang Jie , Liu Ping , Xie Jianwei , Dai Bin
Published: June 2015

2‐Pyrrolecarbaldiminato—Cu(II) complexes are highly efficient catalysts for the one‐pot three‐component cycloaddition of various benzyl halides with alkyl/aryl acetylenes/acetylene gas, and NaN3 leading to 1,4‐disubstituted 1,2,3‐triazoles with high regioselectivity.
ChemInform Abstract: Stereoselective Synthesis and Physicochemical Properties of Liquid‐Crystal Compounds Possessing a trans‐2,5‐Disubstituted Tetrahydropyran Ring with Negative Dielectric Anisotropy.
Authors: Araki Keisuke , Yamamoto Tetsuya , Tanaka Ryoji , Tanaka Saori , Ushioda Makoto , Gotoh Yasuyuki , Yamakawa Tetsu , Inoue Munenori
Published: June 2015

Three alternative stereoselective syntheses of an important liquid‐crystal compound bearing a trans‐2,5‐disubstituted tetrahydropyran ring (VI) are described.
ChemInform Abstract: Copper Catalyzed Room Temperature Lactonization of Aromatic C—H Bond: A Novel and Efficient Approach for the Synthesis of Dibenzopyranones.
Authors: Singha Raju , Dhara Shubhendu , Ghosh Munmun , Ray Jayanta K.
Published: June 2015

The title compounds are efficiently obtained by intramolecular aryl C—H oxidative lactonization of 2‐arylbenzaldehydes using tBuOOH as oxidant and CuCl as low‐cost catalyst.
ChemInform Abstract: Exploring the Scope of the Isothiourea‐Mediated Synthesis of Dihydropyridinones.
Authors: Yeh Pei‐Pei , Daniels David S. B. , Fallan Charlene , Gould Eoin , Simal Carmen , Taylor James E. , Slawin Alexandra M. Z. , Smith Andrew D.
Published: June 2015

Tetramisole‐mediated reaction of 2‐substituted acetic acids (I) and (IV) and α,β‐unsaturated ketimines (II) gives the title compounds in good to high yields and with excellent stereoselectivities.
ChemInform Abstract: Phosphine‐Catalyzed Dearomatizing [3 + 2] Annulations of Isoquinolinium Methylides with Allenes.
Authors: Jia Zhi‐Jun , Daniliuc Constantin Gabriel , Antonchick Andrey P. , Waldmann Herbert
Published: June 2015

The title reaction furnishes highly functionalized pyrroloisoquinolines with high regioselectivity and in moderate to good yields.
ChemInform Abstract: Copper‐ and Ligand‐Free Heteroannulation of o‐Halohydroxypyridine with Terminal Alkynes Using Pd/C Catalyst: One‐Pot Synthesis of 2‐Substituted Furopyridines and Their Functionalization.
Authors: Park Hee Jung , Kim Ji‐Eun , Yum Eul Kgun , Kim Young Hoon , Han Chang‐Woo
Published: June 2015

The double functionalization can be achieved through heteroannulation followed by bromination and Suzuki/Heck reactions (X), (XII).
ChemInform Abstract: Synthesis of Bridged Benzazocines and Benzoxocines by a Titanium‐Catalyzed Double‐Reductive Umpolung Strategy.
Authors: Bichovski Plamen , Haas Thomas M. , Kratzert Daniel , Streuff Jan
Published: June 2015

A sequence of two Ti(III)‐catalyzed reductive umpolung reactions is reported that allows the rapid construction of benzazo‐ and benzoxozine derivatives.
ChemInform Abstract: 7‐endo Cyclization of 2,3‐Epoxyamides and 2,3‐Aziridine Carboxamides by Intramolecular Friedel—Crafts Reaction.
Authors: Palillero‐Cisneros Angel , Gordillo‐Guerra Paola G. , Aparicio‐Solano David M. , Gnecco Dino , Mendoza Angel , Juarez Jorge R. , Teran Joel L.
Published: June 2015

The title reaction gives the products in high yield and in a regio‐ and stereoselective manner.
ChemInform Abstract: Mn(OAc)3‐Mediated Phosphonation—Lactonization of Alkenoic Acids: Synthesis of Phosphono‐γ‐butyrolactones.
Authors: Gao Yuzhen , Li Xueqin , Xu Jian , Wu Yile , Chen Weizhu , Tang Guo , Zhao Yufen
Published: June 2015

The reaction proceeds through Mn(OAc)3‐mediated radical oxidative phosphonation and lactonization of alkenoic acids with H‐phosphonates and H‐phosphine oxide.
ChemInform Abstract: Synthesis and Characterization of Ytterbium Guanidinates Stabilized by Bridged Bis(phenolate) Ligand and Their Application for the Hydrophosphonylation Reaction of Aldehydes.
Authors: Zeng Tinghua , Qian Qinqin , Wang Yaorong , Yao Yingming , Shen Qi
Published: June 2015

Ytterbium guanidinates are shown to be highly efficient catalysts for the hydrophosphonylation of various aldehydes (16 examples) under mild conditions.
ChemInform Abstract: Dysifragilones A—C, Unusual Sesquiterpene Aminoquinones and Inhibitors of NO Production from the South China Sea Sponge Dysidea fragilis.
Authors: Li Yu‐Shan , et al.
Published: June 2015

Three unusual sesquiterpene aminoquinones based on a rearranged avarone skeleton, dysifragilones A (Ia), B (Ib), and C (II), are isolated from the marine sponge Dysidea fragilis.
ChemInform Abstract: Biomimetic Total Synthesis of Gracilioethers B and C.
Authors: Norris Matthew D. , Perkins Michael V. , Sorensen Erik J.
Published: June 2015

The Gracilioethers B (I) and C (II) are synthesized from readily available oxazolidinone in 9 steps with 40% overall yield and 10 steps with 34% overall yields, respectively.
ChemInform Abstract: Nanostructured Mo‐Based Electrode Materials for Electrochemical Energy Storage
Authors: Hu Xianluo , Zhang Wei , Liu Xiaoxiao , Mei Yueni , Huang Yunhui
Published: June 2015

Review: 409 refs.
ChemInform Abstract: Heterocycles from the Reaction of Thione Groups with Acetylenic Bonds
Authors: Aly Ashraf A. , Brown Alan B. , Hassan Alaa A.
Published: June 2015

Review: 179 refs.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition Reactions of Azomethine Ylides with Aromatic Dipolarophiles
Authors: Ryan John H.
Published: June 2015

Review: 77 refs.
ChemInform Abstract: Catalytic Dehydrogenative Aromatization: An Alternative Route to Functionalized Arenes
Authors: Girard Simon A. , Huang Huawen , Zhou Feng , Deng Guo‐Jun , Li Chao‐Jun
Published: June 2015

Review: 36 refs.
ChemInform Abstract: Nafion‐H®: A Versatile Catalyst for Organic Synthesis
Authors: Kidwai Mazaahir , Chauhan Ritika , Bhatnagar Shilpi
Published: June 2015

Review: 269 refs.
ChemInform Abstract: Metal‐Promoted Carboxylation of Alkynes/Allenes with Carbon Dioxide
Authors: Guo Chun‐Xiang , Yu Bing , Ma Ran , He Liang‐Nian
Published: June 2015

Review: 94 refs.
ChemInform Abstract: Electroanalysis of Antioxidants in Pharmaceutical Dosage Forms: State‐of‐the‐Art and Perspectives
Authors: Ziyatdinova Guzel , Budnikov Herman
Published: June 2015

Review: 154 refs.
Oxygen‐Ions‐Mediated Pseudocapacitive Charge Storage in Molybdenum Trioxide Nanobelts
Authors: Kumar Vipin , Wang Xu , Lee Pooi See
Published: June 2015

Here we demonstrate the effect of the concentration of hydrogen peroxide solution on the generation of various kinds of oxygen ions, mainly peroxide (O22−) and superoxide (O2−) ions, on the surface of molybdenum trioxide (MoO3) nanobelts. Due to O22− and O2− ions, the mechanism of charge storage shows an interplay between surface‐controlled and diffusion‐controlled redox reactions. The concentration of H2O2 is indicative of the strength of hydrogen bonding, which significantly affects the concentration or coordination of the surface species (O2−, O22−, Mo5+ and Mo6+) that are available to interact with the electrolyte ions. By altering the concentration of the surface species (IO2−/IO22−, IMo5+/IMo6+), a specific capacitance as high as 210 F g−1 is achieved for MoO3 nanobelts at an applied current density of 0.5 A g−1, with relatively good cycling stability (≈85 %) after 2000 cycles.
TEMPO‐Oxidized Cellulose Cross‐Linked with Branched Polyethyleneimine: Nanostructured Adsorbent Sponges for Water Remediation
Authors: Melone Lucio , Rossi Bianca , Pastori Nadia , Panzeri Walter , Mele Andrea , Punta Carlo
Published: June 2015

Adsorbent sponges for water remediation were prepared using TEMPO‐oxidized cellulose nanofibers (TOCNFs) as three‐dimensional scaffolds, and branched polyethyleneimine (bPEI, 25 KDa) as the cross‐linking agent. TOCNFs were suspended in aqueous solution in the presence of variable amounts of bPEI. The mixtures were first freeze‐dried and then thermally treated (from 60 to 102 °C over 10 h) promoting the formation of amide bonds between the carboxylic groups of TOCNF and the primary amines of bPEI. The resulting materials, which were characterized by FTIR and 13C CP‐MAS NMR spectroscopy, scanning electron microscopy, and elemental analysis, showed higher chemical and mechanical stability in water than non‐reticulated cellulose composites. The high adsorption capability of the new sponges was verified for different organic pollutants (p‐nitrophenol, 2,4,5‐trichlorophenol, and amoxicillin), and heavy metal ion pollutants (Cu, Co, Ni, Cd), indicating their potential for water decontamination.
Investigation of nucleation kinetics and crystal defects of HMX
Authors: Li Wenpeng , Liao Ning , Duan Xiaohui , Pei Chonghua , Zhou Xiaoqing
Published: June 2015

The nucleation kinetics of HMX (cyclotetramethylene tetranitramine, C4H8N8O8) in γ‐butyrolactone was studied in cooling process by induction time method. The laser scattering method was used to measure the solubility data and metastable region of HMX in γ‐butyrolactone. The induction time was measured over a range of supersaturation at different temperatures. Then, the nucleation mechanism of HMX in γ‐butyrolactone was investigated by analysis the relationships between induction time and supersaturation. The results indicated homogeneous nucleation dominated at high supersaturation of S >1.35, while the heterogeneous nucleation dominated at low supersaturation of S < 1.35. The values of interfacial tension at different final temperatures were calculated to indicate the ability of HMX to be crystallized. The growth mechanism of HMX was investigated by the data fitting applying different growth mechanism models and identified as two‐dimensional nucleation‐mediated (2D) growth. Finally, the effects of supersaturation and temperature on the crystal defects were analyzed based on the nucleation kinetics. When the temperature is below 303.15K, homogeneous nucleation dominated the nucleation process at higher supersaturation. Fine HMX crystals with more defects were produced. On the contrary, heterogeneous nucleation mechanism dominated at lower supersaturation. large regular HMX crystals with fewer defects were formed when the temperature is above 318.15K.
The influence of exercise and dehydration on the urine concentrations of salbutamol after inhaled administration of 1600 µg salbutamol as a single dose in relation to doping analysis
Authors: Haase Christoffer Bjerre , Backer Vibeke , Kalsen Anders , Rzeppa Sebastian , Hemmersbach Peter , Hostrup Morten
Published: June 2015

The present study investigated the influence of exercise and dehydration on the urine concentrations of salbutamol after inhalation of that maximal permitted (1600 µg) on the 2015 World Anti‐Doping Agency (WADA) prohibited list. Thirteen healthy males participated in the study. Urine concentrations of salbutamol were measured during three conditions: exercise (EX), exercise+dehydration (EXD), and rest (R). Exercise consisted of 75 min cycling at 60% of VO2max and a 20‐km time‐trial. Fluid intake was 2300, 270, and 1100 mL during EX, EXD, and R, respectively. Urine samples of salbutamol were collected 0–24 h after drug administration. Adjustment of urine concentrations of salbutamol to a specific gravity (USG) of 1.020 g/mL was compared with no adjustment. The 2015 WADA decision limit (1200 ng/mL) for salbutamol was exceeded in 23, 31, and 10% of the urine samples during EX, EXD, and R, respectively, when unadjusted for USG. When adjusted for USG, the corresponding percentages fell to 21, 15, and 8%. During EXD, mean urine concentrations of salbutamol exceeded (1325±599 ng/mL) the decision limit 4 h after administration when unadjusted for USG. Serum salbutamol Cmax was lower (P<0.01) for R(3.0±0.7 ng/mL) than EX(3.8±0.8 ng/mL) and EXD(3.6±0.8 ng/mL). AUC was lower for R (14.1±2.8 ng/mL·∙h) than EX (16.9±2.9 ng/mL·∙h)(P<0.01) and EXD (16.1±3.2 ng/mL·∙h)(P<0.05). In conclusion, exercise and dehydration affect urine concentrations of salbutamol and increase the risk of Adverse Analytical Findings in samples collected after inhalation of that maximal permitted (1600 µg) for salbutamol. This should be taken into account when evaluating doping cases of salbutamol. Copyright © 2015 John Wiley & Sons, Ltd.