bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Remote Sensing Techniques Applicability for Beach Morphology Mapping: A Case Study of Hvar Island, Central Adriatic, Croatia
Authors: Mićunović Marin , Faivre Sanja , Gašparović Mateo
Published: December 2021

This study investigates the quality and accuracy of remote sensing data in beach surveys based on three different data sources covering a 10-year period (2011–2021). Orthophotos from State Geodetic Administration Geoportal and satellite imagery from Google Earth were compared with orthophotos generated from UAV using ArcGIS Pro and Drone2Map. The beach area and length of 20 beaches on the island of Hvar were measured using each data source from different years. The average deviation for beach area (−2.3 to 5.6%) and length (−1 to 2.7%) was determined (without outliers). This study confirms that linear feature measurement is more accurate than polygon-based measurement. Hence, smaller beach areas were associated with higher errors. Furthermore, it was observed that morphological complexity of the beach may also affect the measurement accuracy. This work showed that different remote sensing sources could be used for relatively accurate beach surveys, as there is no statistically significant difference between the calculated errors. However, special care should always be addressed to the definition of errors.
The Endophytic Strain Trichoderma asperellum 6S-2: An Efficient Biocontrol Agent against Apple Replant Disease in China and a Potential Plant-Growth-Promoting Fungus
Authors: Wang Haiyan , Zhang Rong , Duan Yanan , Jiang Weitao , Chen Xuesen , Shen Xiang , Yin Chengmiao , Mao Zhiquan
Published: December 2021

A study was conducted for endophytic antagonistic fungi obtained from the roots of healthy apple trees growing in nine replanted orchards in Shandong Province, China. The fungi were assessed for their ability to inhibit Fusarium proliferatum f. sp. malus domestica MR5, a fungal strain associated with apple replant disease (ARD). An effective endophyte, designated as strain 6S-2, was isolated and identified as Trichoderma asperellum. Strain 6S-2 demonstrated protease, amylase, cellulase, and laccase activities, which are important for the parasitic and antagonistic functions of pathogenic fungi. The inhibition rate of 6S-2 against Fusarium proliferatum f. sp. malus domestica MR5 was 52.41%. Strain 6S-2 also secreted iron carriers, auxin, ammonia and was able to solubilize phosphorus. Its fermentation extract and volatile substances inhibited the growth of MR5, causing its hyphae to twist, shrink, swell, and rupture. The antifungal activity of the 6S-2 fermentation extract increased with increasing concentrations. It promoted the production and elongation of Arabidopsis thaliana lateral roots, and the strongest effects were seen at a concentration of 50 mg/mL. A GC-MS analysis of the 6S-2 fermentation extract and volatile substances showed that they comprised mainly alkanes, alcohols, and furanones, as well as the specific volatile substance 6-PP. The application of 6S-2 spore suspension to replanted apple orchard soils reduced plant oxidative damage and promoted plant growth in a pot experiment. Therefore, the endophytic strain T. asperellum 6S-2 has the potential to serve as an effective biocontrol fungus for the prevention of ARD in China, and appears to promote plant growth.
COVID-19-Associated Pulmonary Aspergillosis in Russia
Authors: Shadrivova Olga , Gusev Denis , Vashukova Maria , Lobzin Dmitriy , Gusarov Vitaliy , Zamyatin Mikhail , Zavrazhnov Anatoliy , Mitichkin Mikhail , Borzova Yulia , Kozlova Olga , Desyatik Ekaterina , Burygina Ekaterina , Ignatyeva Svetlana , Oganesyan Ellina , Vasilyeva Natalya , Klimko Nikolay ,   Working Group
Published: December 2021

We studied the risk factors, etiology, clinical features and the effectiveness of therapy of COVID-19-associated pulmonary aspergillosis (CAPA) in adult patients. In this retrospective study, we included 45 patients with proven (7%) and probable (93%) CAPA. The ECMM/ISHAM, 2020 criteria were used to diagnose CAPA. A case-control study was conducted to study the risk factors of CAPA; the control group included 90 adult COVID-19 patients without IA. In CAPA patients, the main underlying diseases were diabetes mellitus (33%), and hematological and oncological diseases (31%). The probability of CAPA developing significantly increased with lymphocytopenia >10 days (OR = 8.156 (3.056–21.771), p = 0.001), decompensated diabetes mellitus (29% vs. 7%, (OR = 5.688 (1.991–16.246), p = 0.001)), use of glucocorticosteroids (GCS) in prednisolone-equivalent dose > 60 mg/day (OR = 4.493 (1.896–10.647), p = 0.001) and monoclonal antibodies to IL-1ß and IL-6 (OR = 2.880 (1.272–6.518), p = 0.01). The main area of localization of CAPA was the lungs (100%). The clinical features of CAPA were fever (98% vs. 85%, p = 0.007), cough (89% vs. 72%, p = 0.002) and hemoptysis (36% vs. 3%, p = 0.0001). Overall, 71% of patients were in intensive care units (ICU) (median—15.5 (5–60) days), mechanical ventilation was used in 52% of cases, and acute respiratory distress syndrome (ARDS) occurred at a rate of 31%. The lung CT scan features of CAPA were bilateral (93%) lung tissue consolidation (89% vs. 59%, p = 0.004) and destruction (47% vs. 1%, p = 0.00001), and hydrothorax (26% vs. 11%, p = 0.03). The main pathogens were A. fumigatus (44%) and A. niger (31%). The overall survival rate after 12 weeks was 47.2%.
Predictive Biomarkers of Age-Related Macular Degeneration Response to Anti-VEGF Treatment
Authors: Oca Ana I. , Pérez-Sala Álvaro , Pariente Ana , Ochoa Rodrigo , Velilla Sara , Peláez Rafael , Larráyoz Ignacio M.
Published: December 2021

Age-related macular degeneration (AMD) is an incurable disease associated with aging that destroys sharp and central vision. Increasing evidence implicates both systemic and local inflammation in the pathogenesis of AMD. Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is currently the first-line therapy for choroidal neovascularization in AMD patients. However, a high number of patients do not show satisfactory responses to anti-VEGF treatment after three injections. Predictive treatment response models are one of the most powerful tools for personalized medicine. Therefore, the application of these models is very helpful to predict the optimal treatment for an early application on each patient. We analyzed the transcriptome of peripheral blood mononuclear cells (PBMCs) from AMD patients before treatment to identify biomarkers of response to ranibizumab. A classification model comprised of four mRNAs and one miRNA isolated from PBMCs was able to predict the response to ranibizumab with high accuracy (Area Under the Curve of the Receiver Operating Characteristic curve = 0.968), before treatment. We consider that our classification model, based on mRNA and miRNA from PBMCs allows a robust prediction of patients with insufficient response to anti-VEGF treatment. In addition, it could be used in combination with other methods, such as specific baseline characteristics, to identify patients with poor response to anti-VEGF treatment to establish patient-specific treatment plans at the first visit.
Elevated Interleukin-6 Levels in the Circulation and Peritoneal Fluid of Patients with Ovarian Cancer as a Potential Diagnostic Biomarker: A Systematic Review and Meta-Analysis
Authors: Amer Hina , Kartikasari Apriliana E. R. , Plebanski Magdalena
Published: December 2021

Ovarian cancer (OC) is one of the most lethal cancers, largely due to a late diagnosis. This study aimed to provide a comprehensive meta-analysis on the diagnostic performance of IL6 in the blood and ascites separately for advanced and early-stage OC. We included 37 studies with 6948 participants detecting serum or plasma IL6. The plasma/serum IL6 mean level in the late-stage OC was 23.88 pg/mL (95% CI: 13.84–41.23), and the early-stage OC was 16.67 pg/mL (95% CI: 510.06–27.61), significantly higher than the healthy controls at 3.96 pg/mL (95% CI: 2.02–7.73), but not significantly higher than those found in the controls with benign growths in the ovary, which was 9.63 pg/mL (95% CI: 4.16–22.26). To evaluate IL6 in ascites as a diagnostic marker, we included 26 studies with 1590 participants. The mean level of ascitic IL6 in the late-stage OC was 3676.93 pg/mL (95% CI: 1891.7–7146.7), and the early-stage OC was 1519.21 pg/mL (95% CI: 604.6–3817.7), significantly higher than the benign controls at 247.33 pg/mL (95% CI: 96.2–636.0). There was no significant correlation between the levels of circulating and ascitic IL6. When pooling all OC stages for analysis, we found that serum/plasma IL6 provided 76.7% sensitivity (95% CI: 0.71–0.92) and 72% specificity (95% CI: 0.64–0.79). Ascitic IL6 provided higher sensitivity at 84% (95% CI: 0.710–0.919) and specificity at 74% (95% CI: 0.646–0.826). This study highlights the utility of ascitic IL6 for early detection of OC.
Relapsed/Refractory Diffuse Large B-Cell Lymphoma: A Look at the Approved and Emerging Therapies
Authors: Sawalha Yazeed
Published: December 2021

Approximately 40% of patients with diffuse large B cell lymphoma (DLBCL) do not respond or develop relapsed disease after first-line chemoimmunotherapy. A minority of these patients can be cured with autologous hematopoietic stem cell transplantation (AHCT). Although chimeric antigen receptor (CAR) T cells have transformed the treatment paradigm of relapsed/refractory DLBCL, only 30–40% of patients achieve durable remissions. In addition, many patients with relapsed/refractory DLBCL are ineligible to receive treatment with CAR T cells due to comorbidities or logistical limitations. Since 2019, the following four non-CAR T-cell treatments have been approved in relapsed/refractory DLBCL: polatuzumab in combination with bendamustine and rituximab, selinexor, tafasitamab plus lenalidomide, and loncastuximab. In this article, I review the data behind these four approvals and discuss important considerations on their use in clinical practice. I also review emerging therapies that have shown promising early results in relapsed/refractory DLBCL including the bispecific antibodies, antibody–drug conjugates, Bruton tyrosine kinase inhibitors, BCL2 inhibitors, immune checkpoint inhibitors, and epigenetic modifiers.
Monitoring Land Cover Change: Towards Sustainability
Authors: Manakos Ioannis , Gutman Garik , Kalaitzidis Chariton
Published: December 2021

In 2015, the United Nations member states adopted the 2030 Agenda, within which the 17 Sustainable Development Goals (SDGs) were established, with many of these goals calling for further research into sustainability [...]
Influence Mechanism of Production-Living-Ecological Space Changes in the Urbanization Process of Guangdong Province, China
Authors: Deng Yingxian , Yang Ren
Published: December 2021

Referencing the land use classification system of the “production-living-ecological” space and using 1 km × 1 km grids, this study examines the spatial pattern changes of “production-living-ecological” space in Guangdong Province, China, from 1990 to 2017. In the study, a multiple linear regression analysis model was constructed to explore the influencing factors and attribution mechanism of the changes. The results showed that between 1990 and 2017, the production spaces were mainly distributed in the Pearl River Delta and other coastal areas, showing a slight expansion trend (1). The expansion of production spaces mainly gathered in the Pearl River Delta, while the reduction was characterized by point-type dispersed. Living spaces were mainly distributed in the Pearl River Delta, the Shantou–Shanwei–Chaozhou–Jieyang urban agglomeration, the Zhanjiang-Maoming–Yangjiang urban agglomeration, and other rapidly growing urbanized areas. They showed a spatial pattern of “large scale agglomeration and small scale dispersion” with a trend towards expansion. Living spaces in urban agglomerations such as the Pearl River Delta showed a large-scale expansion from the core to the peripheral area, while expansion in other areas was small-scale and point-type. The reduction of living spaces was point-type dispersed. The ecological spaces were mainly distributed in mountainous and hilly areas in eastern, western, and northern Guangdong and showed a “regional agglomeration and partially fragmented” spatial pattern. Ecological spaces in urban agglomerations showed large-scale and regional reductions, while reductions in other areas were small-scale and point-type. Ecological space expansions were point-type dispersed. Human, natural, and especially land-use type factors drove the changes of Guangdong’s production-living-ecological spaces (2). The changes of the production-living-ecological space pattern resulted from the interaction between human society, nature, and politics (3).
The Influence of Political Capital on Peasants’ Migration Behavior and Its Implications
Authors: Shen Haojing , Song Yan , Feng Changchun , Shan Zhengying
Published: December 2021

This study examined the influence of political capital on the migration behavior of peasant households in China’s equitable urbanization. While existing research has proven that political capital can increase the wages of migrant workers, leading to a higher possibility of their rural-to-urban migration, the direct impact of political capital on migration behavior has not received sufficient attention. As China is one of the largest emerging economies, the impact of political capital on the economy and political transformation is typical. This paper reports a survey of 1120 farmer households from Xinxiang, a traditional agricultural area in central China. Using a binary logit model to test whether peasant households will migrate and a multinomial logit model to test where they will migrate to, this study examined whether political capital had a significant influence on the migration behavior of peasant households. The results suggest that the peasant households with political capital have a higher possibility of moving to urban areas, even though there is a better habitational option, namely, a new village in the local rural area. This suggests that reducing the difference in the political capital of migrants through policy propaganda and other methods is an efficient and effective way to achieve and improve equitable access to urbanization.
Policy in Practice: Teachers’ Conceptualizations of L2 English Oral Proficiency as Operationalized in High-Stakes Test Assessment
Authors: Byman Frisén Liliann , Sundqvist Pia , Sandlund Erica
Published: December 2021

Assessment of foreign/second language (L2) oral proficiency is known to be complex and influenced by the local context. In Sweden, extensive assessment guidelines for the National English Speaking Test (NEST) are offered to teachers, who act as raters of their own students’ performances on this high-stakes L2 English oral proficiency (OP) test. Despite guidelines, teachers commonly construct their own NEST scoring rubric. The present study aims to unveil teachers-as-raters’ conceptualizations, as these emerge from the self-made scoring rubrics, and possible transformations of policy. Data consist of 20 teacher-generated scoring rubrics used for assessing NEST (years 6 and 9). Rubrics were collected via personal networks and online teacher membership groups. Employing content analysis, data were analysed qualitatively to examine (i) what OP sub-skills were in focus for assessment, (ii) how sub-skills were conceptualized, and (iii) scoring rubric design. Results showed that the content and design of rubrics were heavily influenced by the official assessment guidelines, which led to broad consensus about what to assess—but not about how to assess. Lack of consensus was particularly salient for interactive skills. Analysis of policy transformations revealed that teachers’ self-made templates, in fact, lead to an analytic rather than a holistic assessment practice.
Variable Future-Time Expression in Spanish: A Comparison between Heritage and Second Language Learners
Authors: Prada Pérez Ana de , Gómez Soler Inmaculada , Feroce Nick
Published: December 2021

This paper examines the expression of futurity in Spanish, specifically the periphrastic future (PF), the morphological future (MF), and the present indicative (PI) in heritage language learners (HLLs) and second language learners (L2 learners), a comparison that allowed us to explore whether linguistic experience provides HLLs an advantage over L2 learners in the domain of morphosyntax. These forms (PF, MF, and PI) are regulated by certainty, temporal distance, and the presence of temporal adverbials. Previous research showed that L2 learners acquire some of these linguistic constraints and that HLLs tend to reduce the MF to modal uses. Data from a contextualized acceptability judgment task completed by 46 HLLs and 42 L2ers manipulated for verb form, certainty, temporal distance, and adverb and revealed that (i) the PF and the MF were generally rated higher than the PI, (ii) HLLs were sensitive to the three linguistic factors examined, while the L2ers’ sensitivity was modulated by proficiency, and, relatedly, (iii) the two groups differed in the effect of proficiency. For the L2 learners, an increase in proficiency led to a closer pattern to that of monolingual native speakers (only for temporal distance). Differences in exposure to and instruction in Spanish are discussed as possible sources of these differences.
Similar Biomechanical Behavior in Gait Analysis between Ceramic-on-Ceramic and Ceramic-on-XLPE Total Hip Arthroplasties
Authors: Triantafyllou Athanasios , Papagiannis Georgios , Nikolaou Vasileios S. , Papagelopoulos Panayiotis J. , Babis George C.
Published: December 2021

In vitro measurements are widely used to implement gait kinematic and kinetic parameters to predict THA wear rate. Clinical tests of materials and designs are crucial to prove the accuracy and validate such measurements. This research aimed to examine the effect of CoC and CoXLPE kinematics and kinetics on wear during gait, the essential functional activity of humans, by comparing in vivo data to in vitro results. Our study hypothesis was that both implants would present the same hip joint kinematics and kinetics during gait. In total, 127 unilateral primary cementless total hip arthroplasties were included in the research. There were no statistically significant differences observed at mean peak abduction, flexion, and extension moments and THA kinematics between the two groups. THA gait kinematics and kinetics are crucial biomechanical inputs associated with implant wear. In vitro studies report less wear in CoC than CoXLPE when tested in a matched gait kinematic protocol. Our findings confirm that both implants behave identically in terms of kinematics in a clinical environment, thus strengthening CoC advantage in in vitro results. Correlated to all other significant factors that affect THA wear, it could address in a complete prism the wear on CoC and CoXLPE.
Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact
Authors: Dordevic Milos , Sulzer Sabrina , Barche Doreen , Dieterich Marianne , Arens Christoph , Müller Notger G.
Published: December 2021

Objectives: In this study, based on the known vestibulo-hippocampal connections, we asked whether mild chronic vestibulopathy leads only to vestibular-related deficits or whether there are effects on hippocampal function, structure, and cognition in general. In more detail, we assessed whether chronic vestibulopathy leads to (a) deficits in vestibular tasks without cognitive demand (balancing), (b) deficits in spatial cognitive tasks that require vestibular input (path integration, rotational memory), (c) deficits in spatial cognitive tasks that do not rely on vestibular input, (d) deficits in general cognitive function, and (e) atrophy in the brain. Methods: A total of 15 patients with chronic uni- or bilateral vestibulopathy (56.8 ± 10.1 years; 4 females) were included in this study and were age- and gender-matched by the control participants (57.6 ± 10.5) in a pairwise manner. Given their clinical symptoms and their deficits of the vestibulo-ocular reflex (VOR) the patients could be classified as being mildly affected. All participants of the underwent the following tests: clinical balance (CBT), triangle completion (TCT) for path integration, rotational memory (RM), the visuo-spatial subset of the Berlin intelligence structure test (BIS-4) and d2-R for attention and concentration, and a structural MRI for gray matter analysis using voxel-based morphometry (VBM). Results: Compared to the healthy controls, the vestibulopathy patients performed significantly worse in terms of CBT, TCT, and RM but showed no differences in terms of the BIS-4 and d2-R. There were also no significant volumetric gray matter differences between the two groups. Conclusions: This study provides evidence that both non-cognitive and cognitive functions that rely on vestibular input (balancing, path integration, rotational memory) are impaired, even in mild chronic vestibulopathy, while other cognitive functions, which rely on visual input (visuo-spatial memory, attention), are unimpaired in this condition, together with an overall intact brain structure. These findings may reflect a segregation between vestibular- and visual-dependent processes in the medial temporal lobe on the one hand and a structure–function dissociation on the other.
Visfatin and Resveratrol Differentially Regulate the Expression of Thymidylate Synthase to Control the Sensitivity of Human Colorectal Cancer Cells to Capecitabine Cytotoxicity
Authors: Wu Kuen-Lin , Lee Ko-Chao , Yen Chia-Kuang , Chen Cheng-Nan , Chang Shun-Fu , Huang Wen-Shih
Published: December 2021

Colorectal cancer (CRC) is a highly lethal malignant cancer. Capecitabine, a 5-fluororacil (5-FU) derivate, is its first-line drug, but the resistance of CRC to capecitabine is still the most challenging factor for curing patients. It has been suggested that thymidylate synthase (TYMS) level might affect the capecitabine efficacy in CRC patients, but the mechanism still needs more elucidation. Obesity is a risk factor for CRC. Recently, a correlation between serum visfatin, an obesity-elicited adipokine, and CRC development has been found. Thus, the aim of present study is to examine the visfatin capacity in TYMS expression and in the development of capecitabine resistance of CRC. Moreover, an attractive natural component, i.e., resveratrol, has been proposed in anticancer therapy and has hence been examined in the present study to see its potential capacity in the alleviation of CRC resistance. Our results found that visfatin significantly reduces the CRC sensitivity to capecitabine by controlling the TYMS expression via p38 signaling and Sp1 transcription factor. Moreover, resveratrol could significantly alleviate the visfatin effect on capecitabine-treated CRC cells. These results provided new insights to understand the capecitabine susceptibility of CRC under a visfatin-containing environment and a possible therapeutic application of resveratrol in CRC patients with obesity.
Convergent Microbial Community Formation in Replicate Anaerobic Reactors Inoculated from Different Sources and Treating Ersatz Crew Waste
Authors: Steinberg Lisa M. , Martino Amanda J. , House Christopher H.
Published: December 2021

Future manned space travel will require efficient recycling of nutrients from organic waste back into food production. Microbial systems are a low-energy, efficient means of nutrient recycling, but their use in a life support system requires predictability and reproducibility in community formation and reactor performance. To assess the reproducibility of microbial community formation in fixed-film reactors, we inoculated replicate anaerobic reactors from two methanogenic inocula: a lab-scale fixed-film, plug-flow anaerobic reactor and an acidic transitional fen. Reactors were operated under identical conditions, and we assessed reactor performance and used 16s rDNA amplicon sequencing to determine microbial community formation. Reactor microbial communities were dominated by similar groups, but differences in community membership persisted in reactors inoculated from different sources. Reactor performance overlapped, suggesting a convergence of both reactor communities and organic matter mineralization. The results of this study suggest an optimized microbial community could be preserved and used to start new, or restart failed, anaerobic reactors in a life support system with predictable reactor performance.
Theoretical Study on Compliance and Stability of Active Gas-Static Journal Bearing with Output Flow Rate Restriction and Damping Chambers
Authors: Kodnyanko Vladimir , Kurzakov Andrey , Grigorieva Olga , Brungardt Maxim , Belyakova Svetlana , Gogol Ludmila , Surovtsev Alexey , Strok Lilia
Published: December 2021

The design is considered and theoretical research of operability of the active radial gas-static bearing with restrictors of output flow rate in the form of mobile rings with an elastic supports and the dampers working by Helmholtz acoustic resonator principle is done. The mathematical model of the bearing dynamics and method of calculating its degree of stability are developed. The device is steady against vibrations; it has smaller power consumption compared to the known devices with input regulators, a zero and negative compliance of a gas-lubricated film.
Adaptive Population NSGA-III with Dual Control Strategy for Flexible Job Shop Scheduling Problem with the Consideration of Energy Consumption and Weight
Authors: Wu Mingliang , Yang Dongsheng , Zhou Bowen , Yang Zhile , Liu Tianyi , Li Ligang , Wang Zhongfeng , Hu Kunyuan
Published: December 2021

The flexible job shop scheduling problem has always been the focus of research in the manufacturing field. However, most of the previous studies focused more on efficiency and ignored energy consumption. Energy, especially non-renewable energy, is an essential factor affecting the sustainable development of a country. To this end, this paper designs a flexible job shop scheduling problem model with energy consideration more in line with the production field. Except for the processing stage, the energy consumption of the transport, set up, unload, and idle stage are also included in our model. The weight property of jobs is also considered in our model. The heavier the job, the more energy it consumes during the transport, set up, and unload stage. Meanwhile, this paper invents an adaptive population non-dominated sorting genetic algorithm III (APNSGA-III) that combines the dual control strategy with the non-dominated sorting genetic algorithm III (NSGA-III) to solve our flexible job shop scheduling problem model. Four flexible job shop scheduling problem instances are formulated to examine the performance of our algorithm. The results achieved by the APNSGA-III method are compared with five classic multi-objective optimization algorithms. The results show that our proposed algorithm is efficient and powerful when dealing with the multi-objective flexible job shop scheduling problem model that includes energy consumption.
Analysing Efficiency and Reliability of High Speed Drive Inverters Using Wide Band Gap Power Devices
Authors: Langmaack Niklas , Lippold Florian , Hu Daiyi , Mallwitz Regine
Published: December 2021

Within the project ‘ARIEL’ an electrical turbo compressor unit for fuel cell applications is deeply investigated. The necessary drive inverter is especially designed for high fundamental frequency and high switching frequency to cope with the requirements of the implemented electrical machine. This paper presents investigations on the inverter’s efficiency and its prospective lifetime at different stages of the development. In the design process different wide band gap power semiconductor devices in discrete packages are evaluated in terms of the achievable power density and efficiency, both by simulations and measurements. Finally, an optimised design using surface mount silicon carbide MOSFETs is developed. Compared to a former inverter design using silicon devices in a three-level topology, the power density of the inverter is significantly increased. The lifetime of power electronic systems is often limited by the lifetime of the power semiconductor devices. Based on loss calculations and the resulting temperature swing of the virtual junction the lifetime of the inverter is estimated for the most frequent operating points and for different mission profiles.
A Systematic Literature Review of Cutting Tool Wear Monitoring in Turning by Using Artificial Intelligence Techniques
Authors: Colantonio Lorenzo , Equeter Lucas , Dehombreux Pierre , Ducobu François
Published: December 2021

In turning operations, the wear of cutting tools is inevitable. As workpieces produced with worn tools may fail to meet specifications, the machining industries focus on replacement policies that mitigate the risk of losses due to scrap. Several strategies, from empiric laws to more advanced statistical models, have been proposed in the literature. More recently, many monitoring systems based on Artificial Intelligence (AI) techniques have been developed. Due to the scope of different artificial intelligence approaches, having a holistic view of the state of the art on this subject is complex, in part due to a lack of recent comprehensive reviews. This literature review therefore presents 20 years of literature on this subject obtained following a Systematic Literature Review (SLR) methodology. This SLR aims to answer the following research question: “How is the AI used in the framework of monitoring/predicting the condition of tools in stable turning condition?” To answer this research question, the “Scopus” database was consulted in order to gather relevant publications published between 1 January 2000 and 1 January 2021. The systematic approach yielded 8426 articles among which 102 correspond to the inclusion and exclusion criteria which limit the application of AI to stable turning operation and online prediction. A bibliometric analysis performed on these articles highlighted the growing interest of this subject in the recent years. A more in-depth analysis of the articles is also presented, mainly focusing on six AI techniques that are highly represented in the literature: Artificial Neural Network (ANN), fuzzy logic, Support Vector Machine (SVM), Self-Organizing Map (SOM), Hidden Markov Model (HMM), and Convolutional Neural Network (CNN). For each technique, the trends in the inputs, pre-processing techniques, and outputs of the AI are presented. The trends highlight the early and continuous importance of ANN, and the emerging interest of CNN for tool condition monitoring. The lack of common benchmark database for evaluating models performance does not allow clear comparisons of technique performance.
On Multistage Multiscale Stochastic Capacitated Multiple Allocation Hub Network Expansion Planning
Authors: Escudero Laureano F. , Monge Juan F.
Published: December 2021

The hub location problem (HLP) basically consists of selecting nodes from a network to act as hubs to be used for flow traffic directioning, i.e., flow collection from some origin nodes, probably transfer it to other hubs, and distributing it to destination nodes. A potential expansion on the hub building and capacitated modules increasing along a time horizon is also considered. So, uncertainty is inherent to the problem. Two types of time scaling are dealt with; specifically, a long one (viz., semesters, years), where the strategic decisions are made, and another whose timing is much shorter for the operational decisions. Thus, two types of uncertain parameters are also considered; namely, strategic and operational ones. This work focuses on the development of a stochastic mixed integer linear optimization modeling framework and a matheuristic approach for solving the multistage multiscale allocation hub location network expansion planning problem under uncertainty. Given the intrinsic difficulty of the problem and the huge dimensions of the instances (due to the network size of realistic instances as well as the cardinality of the strategic scenario tree and operational ones), it is unrealistic to seek an optimal solution. A matheuristic algorithm, so-called SFR3, is introduced, which stands for scenario variables fixing and iteratively randomizing the relaxation reduction of the constraints and variables’ integrality. It obtains a (hopefully, good) feasible solution in reasonable time and a lower bound of the optimal solution value to assess the solution quality. The performance of the overall approach is computationally assessed by using stochastic-based perturbed well-known CAB data.
Renal Impairment Detectors: IGFBP-7 and NGAL as Tubular Injury Markers in Multiple Myeloma Patients
Authors: Woziwodzka Karolina , Małyszko Jolanta , Koc-Żórawska Ewa , Żórawski Marcin , Dumnicka Paulina , Jurczyszyn Artur , Batko Krzysztof , Mazur Paulina , Banaszkiewicz Małgorzata , Krzanowski Marcin , Gołasa Paulina , Małyszko Jacek A. , Drożdż Ryszard , Krzanowska Katarzyna
Published: December 2021

Background and Objectives: Urine insulin-like growth factor-binding protein 7 (IGFBP-7), tissue inhibitor of matrix metalloproteinase 2 (TIMP-2), and neutrophil gelatinase-associated lipocalin (NGAL) monomer are novel tubular kidney injury biomarkers. In multiple myeloma (MM), immunoglobulin free light chains (FLCs) play an integral role in renal impairment. This study aimed to investigate the correlation between new biomarkers and acclaimed parameters of renal failure, MM stage, and prognosis. Materials and Methods: The examined parameters included: urinary and serum cystatin-C, IGFBP-7, and TIMP-2, and urinary NGAL monomer in 124 enrolled patients. Results: Urinary and serum IGFBP-7 and urinary NGAL were higher among patients with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2, and positively correlated with urine light chains. Serum and urine IGFBP-7 and urine NGAL were greater among patients with a higher disease stage. In the whole study group, urinary concentrations of the studied markers were positively correlated with each other. In multiple linear regression, urinary IGFBP-7 and NGAL were associated with lower eGFR, independently of other urinary markers. Conclusions: Urinary IGFBP-7 and NGAL monomer may be useful markers of tubular renal damage in patients with MM. Biomarker-based diagnostics may contribute to earlier treatment that may improve renal outcomes and life expectancy in MM.
Increased Vascular Endothelial Growth Factor Serum Level and the Role of +936C/T Gene Polymorphism in Chronic Obstructive Pulmonary Disease
Authors: Chis Ana Florica , Râjnoveanu Ruxandra-Mioara , Man Milena Adina , Todea Doina Adina , Chis Bogdan Augustin , Stancu Bogdan , Arghir Ioan Anton , Alexescu Teodora Gabriela , Pop Carmen Monica
Published: December 2021

Background and Objectives: Chronic obstructive pulmonary disease (COPD) represents a debilitating disease, with rising morbidity and mortality. Vascular endothelial growth factor (VEGF) plays a major role in angiogenesis, vascular permeability, and airway remodeling. The purpose of this study was to investigate the relationship between VEGF serum levels and VEGF +936 C/T gene polymorphism (rs3025039) with COPD, for the first time in a Romanian population. Materials and Methods: In total, 120 participants from Transylvania were included in this case-control study. Serum levels of VEGF were determined using an enzyme-linked immune-sorbent assay and rs3025039 was investigated by high molecular weight genomic deoxyribonucleic acid (DNA). Spirometric values, arterial blood gas analysis, and the Six Minute Walk Test (6MWT) outcome were also determined. Results: The serum level of VEGF was higher in the COPD group versus controls (p < 0.001), with a positive correlation with the 6MWT outcome. No significant difference was observed in the VEGF serum levels between VEGF +936C/T genotypes. There was no difference in the VEGF +936C/T genotype between COPD patients and healthy subjects (chi2 test p = 0.92, OR = 1.04, 95%CI = 0.41–2.62), but the presence of the T allele was significantly linked to the presence of COPD (chi2 test p = 0.02, OR = 2.36, 95%CI = 1.12–4.97). Conclusions: Higher VEGF serum levels were found in moderate and severe COPD and were positively correlated with the distance in the 6MWT. No significant difference was found between CC, CT, and TT genotypes of rs3025039 and the presence of COPD. The presence of the T allele was found to be linked to COPD and also to the degree of airway obstruction.
Influential Mechanism of Natural Organic Matters with Calcium Ion on the Anion Exchange Membrane Fouling Behavior via xDLVO Theory
Authors: Ma Zhun , Zhang Lu , Liu Ying , Ji Xiaosheng , Xu Yuting , Wang Qun , Sun Yongchao , Wang Xiaomeng , Wang Jian , Xue Jianliang , Gao Xueli
Published: December 2021

The fouling mechanism of the anion exchange membrane (AEM) induced by natural organic matter (NOM) in the absence and presence of calcium ions was systematically investigated via the extended Derjaguin–Landau–Verwey–Overbeek (xDLVO) approach. Sodium alginate (SA), humic acid (HA), and bovine serum albumin (BSA) were utilized as model NOM fractions. The results indicated that the presence of calcium ions tremendously aggravated the NOM fouling on the anion exchange membrane because of Ca-NOM complex formation. Furthermore, analysis of the interaction energy between the membrane surface and foulants via xDLVO revealed that short-range acid–base (AB) interaction energy played a significant role in the compositions of interaction energy during the electrodialysis (ED) process. The influence of NOM fractions in the presence of calcium ions on membrane fouling followed the order: SA > BSA > HA. This study demonstrated that the interaction energy was a dominating indicator for evaluating the tendency of anion exchange membranes fouling by natural organic matter.
Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis
Authors: Schlarmann Philipp , Ikeda Atsuko , Funato Kouichi
Published: December 2021

Sphingolipids are the most diverse class of membrane lipids, in terms of their structure and function. Structurally simple sphingolipid precursors, such as ceramides, act as intracellular signaling molecules in various processes, including apoptosis, whereas mature and complex forms of sphingolipids are important structural components of the plasma membrane. Supplying complex sphingolipids to the plasma membrane, according to need, while keeping pro-apoptotic ceramides in check is an intricate task for the cell and requires mechanisms that tightly control sphingolipid synthesis, breakdown, and storage. As each of these processes takes place in different organelles, recent studies, using the budding yeast Saccharomyces cerevisiae, have investigated the role of membrane contact sites as hubs that integrate inter-organellar sphingolipid transport and regulation. In this review, we provide a detailed overview of the findings of these studies and put them into the context of established regulatory mechanisms of sphingolipid homeostasis. We have focused on the role of membrane contact sites in sphingolipid metabolism and ceramide transport, as well as the mechanisms that prevent toxic ceramide accumulation.
Development of Hydrometallurgical Process for Recovery of Rare Earth Metals (Nd, Pr, and Dy) from Nd-Fe-B Magnets
Authors: Choubey Pankaj Kumar , Singh Nityanand , Panda Rekha , Jyothi Rajesh Kumar , Yoo Kyoungkeun , Park Ilhwan , Jha Manis Kumar
Published: December 2021

Non-availability of rich primary resources of rare earth metals (REMs) and the generation of huge amounts of discarded magnets containing REMs, compelled the researchers to explore the possibilities for the recovery of REMs from discarded magnets. Therefore, the present paper reports the recovery of REMs (Nd, Pr, and Dy) from discarded Nd-Fe-B magnets. The process consists of demagnetization, pre-treatment, and hydrometallurgical processing to recover REMs as salt. Leaching studies indicate that 95.5% Nd, 99.9% Pr, and 99.9% Dy were found to be dissolved at the optimized experimental condition i.e., acid concentration 2 M H2SO4, temperature 75 °C, pulp density 100 g/L, and mixing time 60 min. Solvent extraction technique was tried for the selective extraction/separation of REMs and Fe. The result indicates that 99.1% (24.42 g/L) of Nd along with 90% (1.08 g/L) of Pr and total Fe were co-extracted using 35% Cyanex 272 at organic to aqueous (O/A) ratio 1/1, eq. pH 3.5 in 10 min of mixing time. It requires multistage separation and therefore, not feasible in view of economics. Thus, direct precipitation of REMs salt and iron oxide as pigment was studied using two stages of precipitation at different pH. The obtained precipitate of REMs and Fe hydroxides were dried separately to remove the moisture and further treated at elevated temperature to get pure REMs oxide and red oxide.
Improvement of Shape Error for Slender Parts in Cylindrical Traverse Grinding by Part-Deformation Modelling and Compensation
Authors: Mendez Ivan , Alvarez Jorge , Barrenetxea David , Godino Leire
Published: December 2021

Achieving geometrical accuracy in cylindrical traverse grinding for high-aspect slender parts is still a challenge due to the flexibility of the workpiece and, therefore, the resulting shape error. This causes a bottleneck in production due to the number of spark-out strokes that must be programmed to achieve the expected dimensional and geometrical tolerances. This study presents an experimental validation of a shape-error prediction model in which a distributed load, corresponding to the grinding wheel width, is included, and allows inclusion of the effect of steady rests. Headstock and tailstock stiffness must be considered and a procedure to obtain their values is presented. Validation of the model was performed both theoretically (by comparing with FEM results) and experimentally (by comparing with the deformation profile of the real workpiece shape), obtaining differences below 5%. Having determined the shape error by monitoring the normal grinding force, a solution was presented to correct it, based on a cross-motion of the grinding wheel during traverse strokes, thus decreasing non-productive spark-out strokes. Due to its simplicity (based on the shape-error prediction model and normal grinding force monitoring), this was easily automatable. The corrective compensation cycle gave promising results with a decrease of 77% in the shape error of the ground part, and improvement in geometrically measured parameters, such as cylindricity and straightness.
Effect of Welding Heat Input on Microstructure and Impact Toughness in the Simulated CGHAZ of Low Carbon Mo-V-Ti-N-B Steel
Authors: Qiao Mingliang , Fan Huibing , Shi Genhao , Wang Leping , Wang Qiuming , Wang Qingfeng , Liu Riping
Published: December 2021

Welding thermal cycles with heat inputs ranging from 25 to 75 kJ/cm were performed on a Gleeble 3500. The impact energy improved significantly (from 10 to 112 J), whereas the simulated coarse-grain heat-affected zone (CGHAZ) microstructure changed from lath bainite ferrite (LBF) and granular bainite ferrite (GBF) + martensite/austenite (M/A) to acicular ferrite (AF) + polygonal ferrite (PF) + M/A as the heat input increased. Simultaneously, the mean coarse precipitate sizes and the degree of V(C,N) enrichment on the precipitate surface increased, which provided favorable conditions for intragranular ferrite nucleation. The Ar3 of CGHAZ increased from 593 °C to 793 °C with increasing heat inputs; the longer high-temperature residence time inhibited the bainite transformation and promoted the ferrite transformation. As a result, acicular ferrite increased and bainite decreased in the CGHAZ. The CGHAZ microstructure was refined for the acicular ferrite segmentation of the prior austenite, and the microstructure mean equivalent diameter (MED) in the CGHAZ decreased from 7.6 µm to 4.2 µm; the densities of grain boundaries higher than 15° increased from 20.3% to 45.5% and significantly increased the impact toughness. The correlation of heat input, microstructure, and impact toughness was investigated in detail. These results may provide new ideas for the development of high welding heat input multiphase steels.
Food Microbial Diversity
Authors: Doulgeraki Agapi I. , Tassou Chrysoula C.
Published: December 2021

The microbiological quality and safety of food could be assessed by mapping the microorganisms present in a particular type of food [...]
Relationships between the Gut Microbiota of Juvenile Black Sea Bream (Acanthopagrus schlegelii) and Associated Environment Compartments in Different Habitats
Authors: Sun Peng , Zhang Hui , Jiang Yazhou , Gao Quanxin , Tang Baojun , Ling Jianzhong , Yuan Xingwei
Published: December 2021

The fish-gut microbiota play a key role in the physiology, development, and fitness of its host. An understanding of fish-gut microbial communities and the factors influencing community composition is crucial for improving fish performance. In this study, we compared the gut microbiota of juvenile black sea bream Acanthopagrus schlegelii among habitats: (1) wild, (2) offshore cage-culture, and (3) pond-culture. We also explored the relationships between the gut microbiota and host-associated environmental factors. Gut samples and associated environmental compartments were investigated using 16S rRNA gene sequencing. Our results revealed significant habitat-specific differences among the gut microbiota of juvenile A. schlegelii. Wild populations of juvenile A. schlegelii had more diverse gut microbiota than populations cultured in pond habitats due to their omnivorous feeding habits and the corresponding abundance of natural food resources. Significant variations in the composition, core taxa, and diversity of the microbiota were also found between the gut and the environmental compartments. However, no significant differences were observed among the microbiota of the environmental compartments in the relatively isolated pond habitat. Source tracking analysis recovered connections between the fish-gut microbiota and the diet, water and sediment environmental compartments. This connection was especially strong between the microbiota of the fish gut and that of the diet in the pond habitat: the diet microbiota accounted for 33.48 ± 0.21% of the gut microbiota. Results suggested that all A. schlegelii shared a core gut microbiota, regardless of differences in diet and habitat. However, environmental factors associated with both diet and habitat contributed to the significant differences between the gut microbiota of fish living in different habitats. To the authors’ knowledge, this study presents the first comparison of gut microbiota among juvenile A. schlegelii with different diets and habitats. These findings enrich our understanding of the gut microbiota of A. schlegelii and help to clarify the interaction between gut microbiota and environmental factors. Our results may also help to guide and improve fish ecological fitness via the regulation of gut microbiota, thereby increasing the efficacy of stock enhancement programs for this species.