ISARIC COVID-19 Clinical Data Report: Final report January 2020 – January 2023
Authors:   ISARIC Clinical Characterisation Group, Baillie J. Kenneth , Baruch Joaquin , Beane Abigail , Blumberg Lucille , Bozza Fernando Augusto , Broadley Tessa , Burrell Aidan , Carson Gail , Citarella Barbara Wanjiru , Dunning Jake , Elotmani Loubna , Garcia Barrio Noelia , Goffard Jean-Christophe , Hall Matthew , Hashmi Madiha , Horby Peter , Jassat Waasila , Kartsonaki Christiana , Kumar Tirupakuzhi Vijayaraghavan Bharath , Kumar Vecham Pavan , Laouenan Cedric , Lissauer Samantha , Martin-Loeches Ignacio , Mentre France , Morton Ben , Munblit Daniel , Nekliudov Nikita A. , Nichol Alistair , Ong David S.Y. , Panda Prasan Kumar , Jimenez Miguel Pedrera , Petrovic Michelle , Ramakrishnan Nagarajan , Ramos Grazielle Viana , Roger Claire , Rojek Amanda , Sandulescu Oana , Semple Malcolm G. , Sharma Pratima , Shrapnel Sally , Sigfrid Louise , Sim Lim Heng Benedict , Singh Budha Charan , Somers Emily , Streinu-Cercel Anca , Taccone Fabio S. , Wei Jia , Wils Evert-Jan , Wong Xin Ci , Young Kyle , Olliaro Piero L. , Merson Laura 
Published: July 2020

ISARIC (International Severe Acute Respiratory and emerging Infections Consortium) partnerships and outbreak preparedness initiatives enabled the rapid launch of standardised clinical data collection on COVID-19 in Jan 2020. Extensive global participation has resulted in a large, standardised collection of comprehensive clinical data from hundreds of sites across dozens of countries. Data are analysed regularly and reported publicly to inform patient care and public health response. This report, our 18th and final report, is a part of a series published over 3 years. Data have been entered for 945,317 individuals from 1807 partner institutions and networks across 76 countries.

The comprehensive analyses detailed in this report includes hospitalised individuals of all ages for whom data collection occurred between 30 January 2020 and up to and including 10 January 2023, AND who have laboratory-confirmed SARS-COV-2 infection or clinically diagnosed COVID-19.

For the 845,291 cases who meet eligibility criteria for this report, selected findings include:

Median age of 57 years, with an approximately equal (50/50) male:female sex distribution

29% of the cohort are at least 70 years of age, whereas 6% are 0-19 years of age

The most common symptom combination in this hospitalised cohort is shortness of breath, cough, and history of fever, which has remained constant over time

The five most common symptoms at admission were shortness of breath, cough, history of fever, fatigue/malaise, and altered consciousness/confusion, which is unchanged from the previous reports

Age-associated differences in symptoms are evident, including the frequency of altered consciousness increasing with age, and fever, respiratory and constitutional symptoms being present mostly in those 40 years and above

15% of patients with relevant data available (845,291) were admitted at some point during their illness into an intensive care unit (ICU), which has decreased from 19% during the 3 years of ISARIC reporting

Antibiotic agents were used in 37% of patients for whom relevant data are available (802,241), a significant reduction from our previous reports (80%) which reflects a shifting proportion of data contributed by different institutions; in ICU/HDU admitted patients with data available (64,669), 90% received antibiotics

Use of corticosteroids was reported in 25% of all patients for whom data were available (809,043); in ICU/HDU admitted patients with data available (64,713), 71% received corticosteroids

Outcomes are known for 762,728 patients and the overall estimated case fatality ratio (CFR) is 22% (95%CI 21.9-22), rising to 36% (95%CI 35.6-36.1) for patients who were admitted to ICU/HDU, demonstrating worse outcomes in those with the most severe disease

To access previous versions ofISARIC COVID-19 Clinical Data Reportplease use the link below:https://isaric.org/research/covid-19-clinical-research-resources/evidence-reports/