bluuebunny/crossref_metadata_2025 huggingface dataset:
DEVELOPMENT AND OPTIMIZATION OF THE WOUND HEALING ELECTROSPUN POLYURETHANE/COLLAGEN/PHYTOCERAMIDES NANOFIBERS USING THE BOX-BEHNKEN EXPERIMENTAL DESIGN) QUALITY BY DESIGN)
Authors: M. EWEDAH TASSNEIM , EL-NABARAWI MOHAMED , H. TEAIMA MAHMOUD , ELHABAL SAMMAR FATHY , R. SHOUEIR KAMEL , HAMDY ABDALLAH M. , ABDALLA AHMED
Published: September 2024

Objective: This study aimed to develop and optimize polyurethane/collagen/phytoceramides nanofibers, a wound-healing drug delivery approach, using the electrospun technique. The objective was to enhance the effectiveness of nanofibers by optimizing the preparation process.
Methods: The box-behnken design was established to optimize the electrospinning instrument performance and, consequently, the nanofiber effectiveness. Response variables were diameter, zeta potential, and diffusion coefficient, while the experimental key factors were applied voltage, flow injection rate, and rotary collector speed of the electrospinning instrument. The optimized nanofibers were examined to ensure the validity of the optimization process.
Results: The study built prediction models for each response and employed a desirability function to suggest an optimum working level of each factor that guarantees minimum diameter, maximum zeta potential, and maximum diffusion coefficient. The desirability function suggested experimental conditions of 12.9 KV for the applied voltage, 1.3 ml/h for the injection flow rate, and a speed of 920 rpm for the rotary collector speed. The optimized formula proved satisfactory physicochemical properties regarding the nanofiber's infrared spectrum and wettability characteristics. The biomedical effectiveness of the optimized nanofibers showed increased anti-inflammatory potency up to 82.8±2.6% and a high wound closure rate of about 79%. Also, the stability study showed a nonsignificant change in response over the studied points.
Conclusion: The optimized nanofiber formula achieved the desired diameter, zeta potential, and diffusion coefficient. The results proved the Box-Behnken design approach's efficacy in enhancing the nanofiber formula's effectiveness and stability.
MOLECULAR TARGETS AS POTENTIAL PI3Kα INHIBITORS AGAINST AGGRESSIVE METASTATIC DUCTAL AND LOBULAR CARCINOMA
Authors: MATHEW ARPITH , DAS SUBHAM , JOSEPH LATE ALEX , BIRANGAL SUMIT RAOSAHEB , MATHEW JANE
Published: September 2024

Objective: This study aimed to identify active compounds among existing molecules by drug repositioning as potential hits of Phosphoinositide 3-Kinase (PI3Kα) inhibitors. FDA-approved ligands were docked using structure-based in silico screening, and the top ten molecules based on docking score were studied for their in silico pharmacokinetic and ligand-receptor interactions.
Methods: FDA-approved ligands were docked with the protein PI3Kα enzyme (PDP ID: 4JPS) and were checked for their molecular interactions and docking scores using the GLIDE program of Schrödinger software. The top 10 ligands were subjected to ADMET and MMGBSA studies to predict pharmacokinetic properties and binding affinity. The best two molecules and the standard alpelisib were subjected to Molecular dynamics with 100 nsec simulation time to deduce interaction at the atomic level.
Results: Two molecules, ZINC000003794794 (Mitoxantrone) and ZINC000004098633 (Polydatin), were found to be promising based on docking score, ligand interaction diagram, and MMGBSA scores of-13.084 and-11.364 and-75.38 and-58.88 respectively and were in a comparable range to the standard alpelisib. These two molecules were then subjected to Induced Fit Docking (IFD) and molecular dynamics to better understand protein stability and inhibitor activity in physiological conditions. The IFD values of these molecules were very close to the standard, and the residues of the best poses coincided with the desired residues, such as V851, S854, and Q859, seen in the alpelisib.
Conclusion: However, further in vitro and in vivo screening is needed to confirm the PI3Kα inhibitory activity of these ligands, which could serve as promising lead molecules in treating TNBC with fewer side effects compared to existing drugs.
FORMULATION, CHARACTERIZATION, AND TYROSINASE INHIBITORY ASSAYS OF NIACINAMIDE-LOADED NANOPARTICLE GEL AS A SKIN WHITENING AGENT
Authors: AHDYANI RISA , LATIFAH NOR , SA’ADAH HAYATUS , FATMASARI ERLINA , ZAMZANI IRFAN
Published: September 2024

Objective: This research aims to formulate a nanoparticle gel of Niacinamide (N) using Chitosan (C) and Sodium Alginate (SA) and determine its tyrosinase inhibitory activity as a skin whitening.
Methods: N nanoparticle was carried out using C (0.01%), SA (0.1%), and Calcium Chloride (CC 0.25 %). N was incorporated into the nanoparticle system by different concentrations in each Formula (F): F1(2.5 %), F2 (5%), F3 (7.5%), and F4 (10%). Each formula was characterized for particle size, Polydispersity Index (PI), and Zeta potential by Zetasizer, entrapment efficiency using Spectrophotometer Uv-Vis, and molecular structure using Fourrier Transform Infrared (FTIR). Then, Hydroxy Propyl Methyl Cellulose (HPMC) was incorporated to form a nanoparticle gel of N. N-loaded nanoparticle gel was determined tyrosinase inhibitory using L-tyrosine to obtain Inhibitory Concentration of 50 (IC50) value. Furthermore, data was analyzed using one-way ANOVA (p-value<0.05).
Results: The particle size, PI, Zeta potential, and entrapment efficiency obtained for all formulations were found to be F1 (217±7.21 nm, 0.49±0.0521,+8.24±1.75 mV, and 61.22±2.88 %); F2 (225±11.37 nm, 0.51±0.0246,+9.12± 1.97 mV, and 64.01±4.12%); F3 (289±15.26 nm, 0.26±0.0152,+10.55± 1.56 mV, and 68.71±3.86 %); F4 (428±9.44 nm, 0.38±0.0347, 12.33±1.80 mV, and 72.59±3.01%) respectively. The result of FTIR spectra indicated N-loaded in the nanoparticles system. Tyrosinase inhibitory activity of N-loaded gel nanoparticles obtained IC50 99.9775, 73.5605, 52.7187, and 42.3145 μg/ml, respectively.
Conclusion: N-loaded nanoparticle gel was successfully prepared and could be a promising candidate for skin whitening agent.
De los azúcares y de cómo regulan las plantas su propio alimento
Authors: Romero-Reyes Andrea , Valenzuela-Soto Elisa M.
Published: September 2024

En las células de todo ser vivo, es importante mantener los niveles de energía adecuados de acuerdo con sus requerimientos. Para que nuestro cuerpo esté en equilibrio, los humanos podemos cuidar nuestra dieta y realizar actividad física. En cambio, las plantas, transforman la energía proveniente de la luz solar en energía química y azúcares gracias a la fotosíntesis; el almidón y la sacarosa son dos de los azúcares más importantes para las plantas, pues de ahí obtienen la energía necesaria para su adecuado desarrollo. Además de ser autótrofas, las plantas son inmóviles, entonces, ¿cómo regulan las células sus niveles de energía? En este artículo te explicamos cómo algunos azúcares, más allá de proveer energía, le indican a la célula cómo mantener el equilibrio, regulando así el crecimiento de las plantas.
Tecnología y salud mental: agentes virtuales para intervenciones breves motivacionales
Authors: Mercado José , Delgado-Pérez Edwin Emeth , Martínez-Miranda Juan
Published: September 2024

Los problemas de salud mental afectan el bienestar y tienen un impacto en la capacidad laboral y relaciones interpersonales de quienes los presentan. La atención a estos problemas es baja en muchos países, incluyendo México, debido a factores más allá de lo económico. La tecnología puede incrementar la disponibilidad y accesibilidad a tratamientos y maximizar los resultados psicoterapéuticos. Como ejemplo, aquí se presentan los fundamentos y el desarrollo de una aplicación móvil con un agente virtual conversacional, cuyo objetivo es fomentar la adherencia al tratamiento psicoterapéutico de problemas de ansiedad y depresión, mediante intervenciones breves motivacionales.
Los roedores: animales fantásticos y dónde encontrarlos
Authors: Montero Bagatella Sandra H. , Cervantes Reza Fernando A.
Published: September 2024

Los roedores suelen ser percibidos erróneamente como criaturas indeseables y perjudiciales. Sin embargo, estos pequeños mamíferos desempeñan funciones ecológicas esenciales en los ecosistemas donde viven. Al dispersar semillas, facilitar la polinización y servir de alimento para aves, reptiles y otros mamíferos, los roedores contribuyen a dinámicas ecológicas que benefician tanto a la fauna como a la flora, lo que los posiciona como especies clave e ingenieros del ecosistema. Además, tienen un impacto directo y significativo en la vida humana, desde su papel como mascotas hasta su uso en investigaciones médicas. Sin embargo, las actividades humanas han llevado a la degradación y pérdida de muchos de sus hábitats, poniendo en peligro a numerosas especies. Por ello, es fundamental promover un entendimiento preciso sobre estos animales para fomentar su conservación efectiva.
A Framework for Developing Correct Software Programs through Software Defect Prediction and Elimination using Machine Learning Models
Authors: Choudhury Madhab Paul
Published: September 2024

Software Defect Prediction [SDP] is an important item for development of mistake free software. A software defect is an error, bug, flaw, fault, malfunction or mistakes. If software defect is present in the software, the output produced from that software becomes erroneous. If defect is present in the software, time, cost, effort will be lost and there will be wastage of resources. Therefore, it is necessary is to determine the defects in an early phase of software development. For this purpose, Kaggle software defect data set(ant-1.3) [11] have been used. Machine learning models like Random Forest, Decision Tree, Logistic Regression, K-nearest neighbour, Gaussian Naïve Bayes, Support Vector Machine using linear function and Radial basis function, Gradient Boosting algorithm have been used. Accuracy, classification report and confidence matrix have been used as an evaluation parameter for selecting a particular machine learning model. After the selection of machine learning model based on accuracy, classification report and confidence matrix, the particular machine learning model has to be selected. It is necessary to find out the contribution of software parameters which are responsible for eliminating fault from software in a better way in the computer software.
Exploring Legal Protections for Platform Workers in Malaysia: A Human Rights-Based Perspective
Authors: Makhtar Maheran , Ghadas Zuhairah , Haque Mahbubul
Published: September 2024

Platform work has gained significant recognition due to the rapid growth of the digital economy, which offers new opportunities for workers. However, inadequate regulatory frameworks in Malaysia have led to various human rights concerns, particularly regarding the protection of workers' rights, such as social security, fair remuneration and safe working conditions. Furthermore, the challenge of providing worker protections must be balanced with the flexible nature of the gig economy. Thus, this study explored the evolving legal landscape surrounding the protection of platform workers’ rights in Malaysia from both legal and human rights perspectives. It examines the role of business and human rights in finding the delicate balance between economic progress and protecting workers’ fundamental rights, emphasizing the role of regulation. This study adopts a qualitative approach through review of existing literature, including academic research, reports, and relevant legal documents, to provide a comprehensive understanding of the issue. Therefore, this study underscores the urgent need for robust legal frameworks and regulatory measures to safeguard the rights and welfare of platform workers in Malaysia through the integration of corporate responsibility to respect human rights and to establish mechanisms that guarantee fair remuneration, job security, social protection, and avenues for workers’ representation and collective bargaining. The findings of this study are expected to contribute to the growing body of literature on platform work and serve as a basis for policy recommendations and advocacy efforts to improve the rights and working conditions of platform workers in Malaysia.
Operator Responsibilities in Safeguarding Consumer Rights Against GPS Spoofing in Ride-Hailing Services
Authors: Salvia Hana , Priowirjanto Enni , Suwandono Agus
Published: September 2024

This study examines the responsibilities of Electronic System Providers (ESPs) in safeguarding consumer rights within ride-hailing services. It specifically addresses the Global Positioning System (GPS) spoofing by drivers. The GPS spoofing involves the deceitful manipulation of location data by vehicles, posing significant legal and security risks to customers. The study evaluated the effectiveness of ESPs, including popular platforms in Indonesia like Gojek and Grab, in protecting consumers from such violations. It utilized normative legal theory and the secondary data analysis derived from ESP contracts. Findings indicate that current consumer protection measures are insufficient, primarily because ESPs employ exemption clauses that contravene Consumer Protection Law regulations. Additionally, the study highlights a lack of compliance with governance laws, such as the Government Regulation Number 71 of 2019, which mandates ESPs to establish robust and effective electronic system governance. This unethical practice jeopardizes consumer safety and erodes trust in the ESPs. This study underscores the necessity for stricter enforcement of consumer protection laws and regulations within the ride-hailing sector to ensure client safety and security. ESPs must prioritize safeguarding consumer data and implement measures to prevent drivers from manipulating fraudulent location data. Furthermore, collaborative efforts among ESPs, governmental bodies, and cybersecurity experts are essential to enhance legal protections for consumers, aiming to establish fair and safe procedures that benefit all parties involved.
Disclosure Principle as Ex-Ante Rules for Combating Big Tech’s Abuse of Dominance in Digital Market: A Comparative Analysis
Authors: Rakhmawati Catur
Published: September 2024

This study discusses the weaknesses of Law Number 5 of 1999 on the Prohibition of Monopolistic Practices and Unfair Business Competition in handling the abuse of dominance by big tech in the digital market. This study also explores lessons from how the European Union (EU) and Japan implement the disclosure principle to prevent such abuse. This normative study employs statutory, conceptual, and comparative approaches. The findings are as follows: first, Law Number 5 of 1999 does not implement ex-ante measures such as the “disclosure principle,” and prevention efforts are practically non-existent, particularly in handling dominance abuse. Second, a comparative study of the EU and Japan found that the EU has enacted the Digital Markets Act (DMA), which comprehensively regulates the abuse of dominance by big tech companies and categorizes them as gatekeepers. The DMA establishes the gatekeeper threshold and includes the duty to notify the European Commission voluntarily under Articles 5, 6, and 7 of the DMA. Japan has the Act on Improving Transparency and Fairness of Digital Platforms 2021, an ex-ante regulation that implements the disclosure principles on digital platforms. Based on these two comparisons, the main idea of such regulations is to implement the disclosure principle as an ex-ante rule for business actors who meet the threshold and to burden them with certain obligations. This approach allows authorities to perform supervision and prevent abuse of dominance by big tech optimally.
Pengaruh Daya Tarik Wisata dan Seni Fotografi dalam Meningkatkan Keputusan Berwisata
Authors: Aling Florenza Angeli Nazaretha , Semara I Made Trisna , Amir Firlie Lanovia
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pengaruh daya tarik wisata dan seni fotografi secara parsial dan simultan terhadap keputusan berwisata di KDTWK Kintamani. Pengambilan sampel terhadap responden dalam penelitian ini yaitu sebanyak 100 responden. Teknik analisis data yang digunakan dalam penelitian ini adalah Uji Analisis Regresi Linear Berganda. Dari hasil penelitian dapat dilihat bahwa daya tarik wisata scecara simultan berpengaruh positif signifikan terhadap keputusan berwisata, kemudian seni fotografi juga berpengaruh positif signifikan terhadap keputusaan berwisata oleh wisatawan Besarnya pengaruh pemasaran daya tarik wisata dan seni fotografi terhadap keputusan berwisata adalah 59,2%. Kesimpulannya semakin baik daya tarik wisata dan aktivitas seni fotografi yang terdapat di KDTWK Kintamani, maka akan semakin meningkatkan keputusan wisatawan dalam berwisata di KDTWK Kintamani.
 
This research aims to determine the partial and simultaneous influence of tourist attractions and the art of photography on travel decisions at KDTWK Kintamani. The sampling of respondents in this research was 100 respondents. The data analysis technique used in this research is the Multiple Linear Regression Analysis Test. From the research results, it can be seen that tourist attractions simultaneously have a significant positive effect on travel decisions, then the art of photography also has a significant positive effect on tourists' travel decisions. The magnitude of the influence of tourist attraction marketing and photography art on travel decisions is 59.2%. In conclusion, the better the tourist attraction and photography art activities found at KDTWK Kintamani, the more it will improve tourists' decisions about traveling to KDTWK Kintamani.
Práticas pedagógicas inspiradas na abordagem Reggio Emilia durante a pandemia da COVID-19 no Brasil
Authors:   , Paula Aléxia Roche de Oliveira
Published: September 2024

A abordagem Reggio Emilia para a educação infantil é reconhecida como respeitosa e adequada à natureza da criança, por contemplar o protagonismo infantil, a colaboração, a cooperação, aprendizagem baseada em projetos e a expressão por meio de diferentes linguagens. A pandemia da COVID-19, iniciada em 2020, fez com que a escola adentrasse aos lares dos estudantes. Partindo da pergunta “Como foram desenvolvidas as práticas pedagógicas durante a pandemia?”, o presente estudo objetivou compreender como os professores desenvolveram suas práticas, em relação à interação e aos momentos formativos diante da nova configuração de ensino, gerada pelo isolamento obrigatório. A relevância desta pesquisa está em contemplar uma temática atual e necessária para compreender o processo de ensino e aprendizagem no contexto pandêmico. O delineamento da pesquisa envolveu levantamento bibliográfico e estudo de campo, com aplicação de entrevistas semiestruturadas com professores e equipe gestora das escolas e análise documental. Quanto aos objetivos, caracteriza-se como exploratória e descritiva, com abordagem qualitativa. A técnica de análise dos dados coletados selecionada foi a análise de conteúdo. Os resultados coletados apontaram para a utilização de atividades lúdicas que possibilitaram a exploração de diferentes materiais pelas crianças, além disso, o estudo mostra que houve um comprometimento na qualidade da interação durante a pandemia.
teste com entidade
Authors:   , Souza Jesaías da Silva
Published: September 2024

teste
Instrumenty finansowania lokalnych projektów rewitalizacyjnych
Authors: Gralak Katarzyna
Published: September 2024

W artykule przedstawiono źródła i instrumenty finansowania rewitalizacji w Polsce oraz dokonano analizy poziomu wykorzystania publicznych instrumentów finansowania rewitalizacji w województwie mazowieckim. W analizie uwzględniono poziom zaangażowania środków unijnych w finansowanie projektów rewitalizacyjnych oraz przedstawiono instrumenty i przykłady zaangażowania podmiotów prywatnych na obszarze rewitalizowanym w realizacje planu i projektów.
Strategie rozwoju powiatów oraz fundusze strukturalne UE jako instrumenty kreowania ładu przestrzennego
Authors: Rakowska Joanna , Wojewódzka Agnieszka
Published: September 2024

W artykule określono związek pomiędzy faktem istnienia strategii rozwoju powiatów, a wykorzystaniem środków unijnych w okresie programowania 2004-2006. Scharakteryzowano instrumenty jakie są możliwe do wykorzystania przez jednostki samorządu terytorialnego w celu kształtowania ładu przestrzennego. W części empirycznej wykorzystano dane Ministerstwa Rozwoju Regionalnego (2009) oraz wyniki badań ankietowych przeprowadzonych w starostwach powiatowych w 2008 roku. Stwierdzono, że możliwość i zasady pozyskiwania środków finansowych z funduszy strukturalnych wymusiła na starostwach powiatowych opracowanie dokumentów planistycznych, w tym strategii lub planów rozwoju. Doprowadziło to do znacznego uzupełnienia dokumentów planistycznych w powiatach – beneficjentach programów unijnych. W efekcie powstał porządek organizacyjny, który w bieżącym okresie programowania może skutkować efektywniejszym wykorzystaniem instrumentów kształtowania ładu przestrzennego, włączając zewnętrzne środki finansowe.
The expression of signal regulatory protein alpha (SIRPα) in periodontal cells and tissue
Authors: Koskinen Holm Cecilia , Rosendahl Sara , Oldenborg Per-Arne , Lundberg Pernilla
Published: September 2024

Signal regulatory protein alpha (SIRPα) is mainly expressed by cells of myeloid origin. This membrane glycoprotein is shown to be involved in regulation of different inflammatory conditions, such as colitis and arthritis. However, SIRPα has not been investigated in relationship to periodontitis, an inflammatory condition affecting the tooth supporting tissues. We aim to investigate if resident cells in the periodontium express SIRPα and whether a possible expression is affected by inflammatory conditions. Primary human keratinocytes, fibroblasts, periodontal ligament cells, and osteoblasts were cultured with or without the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) or interleukin-1-beta (IL-1β). All different periodontal cell types showed a basal mRNA expression of SIRPα. Pro-inflammatory cytokines induced a 2–3-fold significant increase in SIRPα expression in both cultured human gingival fibroblasts and osteoblasts but neither in keratinocytes nor in periodontal ligament cells. Tissue sections from human gingival tissue biopsies were histochemically stained for SIRPα. Epithelial keratinocytes and gingival fibroblasts stained positive in sections from periodontally healthy as well as in sections from periodontitis. In periodontitis sections, infiltrating leukocytes stained positive for SIRPα. We highlight our finding that oral keratinocytes, gingival fibroblasts, and periodontal ligament cells do express SIRPα, as this has not been presented before. The fact that inflammatory stimulation of gingival fibroblasts increased the expression of SIRPα, while an increased expression by gingival fibroblasts in periodontitis tissue in situ could not be detected, is indeed contradictory.
QUALITY OF VIRGIN COCONUT OIL PRODUCTION USING PINEAPPLE FLESH AND SKIN BASED ON CHEMICAL PARAMETERS
Authors: Indahsari Lilin Eka Nur , Ramadhani Ayu Novita
Published: September 2024

This research aims to describe the quality of VCO made using pineapple skin and flesh based on chemical parameters. The chemical parameters examined in this research are free fatty acid (FFA) content, 10 types of fatty acids, peroxide value, and heavy metal contamination consisting of iron (Fe), Cadmium (Cd), Copper (Cu), and Lead. (Pb). The results of measuring several parameters are then compared with the quality of VCO based on Indonesian National Standards (SNI). The measurement results show that the free fatty acid content in VCO pineapple flesh is 0.55% and pineapple skin is 1.37%. Meanwhile, the fatty acid content required in SNI is a maximum of 0.2. The content of all types of fatty acids meets the levels specified in SNI. Next, the peroxide value obtained for pineapple flesh VCO is 1.83 mg ek/kg, pineapple skin VCO is 1.63 1.83 mg ek/kg, the levels specified in SNI are a maximum of 2.0 1.83 mg ek/kg. kg. Measurement of heavy metal contamination data obtained for pineapple flesh VCO, namely Fe 2.66 mg/kg, Cd <0.001 mg/kg, Cu 0.172 mg/kg, and Lead <0.001 mg/kg. Heavy metal contamination for pineapple skin VCO is Fe 3.85 mg/kg, Cd <0.001 mg/kg, Cu 0.041 mg/kg, and Lead <0.001 mg/kg. Based on the measurement data that has been obtained, it can be concluded that VCO made with fruit enzymes and pineapple peel meets SNI standards for the parameters of fatty acid content, peroxide value and heavy metal contamination, but does not meet the standards for free fatty acid content indicators. The high levels of free fatty acids in VCO indicate that there is excessive water content in the fruit VCO and pineapple skin.
Comparis on of Tinospora cordiofolia and 0.2% Chlorhexidine Mouthrinse for Treatment of Gingivitis
Authors: Tiwari Superna , AM Savita , BK Nanjwade , CTT Thao , J Jenis , AB Sarkar , SF Ng , T Srichana
Published: September 2024

Background: Plaque control has been the key factor in maintenance of oral hygiene. Chlorhexidine (CHX) is considered as gold standard in the treatment of gingivitis, however side effects such as staining of teeth and altered taste sensation, limits its use for longer periods. Ayurvedic drugs, on the other hand, have been proved to be safer for long term usage. Tinospora cardiofolia (T. cardiofolia) also called as guduchi is known to have antibacterial, anti-inflammatory and antioxidant properties. Aim: To evaluate the efficacy of Tinospora cardiofolia (T. cordiofolia) in the treatment of gingivitis and to compare its efficacy with the gold standard chlorhexidine. Materials and Methods: 30 systemically healthy patients with MGI score greater ≥2 were recruited for the study and were randomly assigned into 3 groups; Group A- Herbal mouthrinse: Group B- Placebo: Group C- 0.2% Chlorhexidine. Baseline indices were recorded. Thorough scaling was performed and plaque scores were brought to zero. Patients were instructed to use given mouthrinse 15 ml for 60 sec twice daily. All the indices were repeated at the end of 21 days. Results: Reduction of all indices scores were observed in all the groups at 21st day. Chlorhexidine showed better results when compared to Guduchi.
Different Nanomaterials in Beauty Care Products
Authors: Nikam Rutuja , Y Sharma , D Patil
Published: September 2024

The two greatest technology of the twenty-first century, biotechnology and nanotechnology, offer tremendous growth and development potential. The manufacturing of nanoscale biomolecular materials and analytical equipment for cellular damage and macro cell biology research make up both academic and commercial uses of these technologies. Thanks to developments in nanotechnology, the area of aesthetic dermatology will be able To produce unusual, enhanced chemicals, means of delivery, and biocompatible and biodegradable medicines. Skincare are mostly used to keep skin and surroundings healthful while producing a flawless look, shifting appearance, or minimizing foul smells. Cosmetic dermatology must consequently emphasize the functional components of cosmetics by evaluating their efficacy and safety in boosting health, given the ever-changing reality of skin care products.
Exploring the Nexus of Nanoparticles and Homoeopathic Potentized Medicine: A Narrative Review
Authors: S Sheeba , ST Gopukumar , S Ramya , S Sanju , R Reghu , JP Shimmal Chenthik
Published: September 2024

Homoeopathy, a system of alternative medicine, has long intrigued researchers and practitioners alike with its principles of dilution and potentization. Recently, the interaction between homoeopathic potentized medicines and nanoparticles has garnered attention, sparking debates and investigations into their potential correlation. Homoeopathic medicines primed at such great enfeeblements through no corporeal being of uniform, correspondingly solitary fragment of the unique ingredient is alleged to be hypothetically bizarre. This narrative review explores the current understanding of nanoparticles in relation to homoeopathic potentized medicine, highlighting emerging research, challenges, and prospects for future exploration.
Revolutionizing Dosage Form Design: The Impact of 3D Printing in Pharmaceuticals
Authors: Vinchurkar Kuldeep , R Doke
Published: September 2024

3D printing is revolutionizing pharmaceutical manufacturing by creating personalized dosage forms and intricate drug delivery systems. This technology offers flexibility and precision, enhancing patient compliance, reducing side effects, and improving treatment effectiveness. It excels in producing complex geometries that alter drug release mechanisms, making it difficult to achieve with conventional methods. Key considerations for developing 3D-printed pharmaceuticals include patient population, molecule type, dosage accuracy, and regulatory compliance. Despite its advantages, 3D printing faces technical challenges and regulatory hurdles. Collaborative efforts between industry experts and regulatory bodies are essential for establishing clear guidelines and standards. Ultimately, 3D printing holds the potential to decentralize production, enhance treatment efficacy, and create a more sustainable and patient-centric pharmaceutical industry
Unlocking the Potential of Nanomedicine and Nanotechnology: A New Era of Innovation
Authors: Mathad Shridhar
Published: September 2024

Nanoscience has essentially changed our approach to science, allowing us to manipulate and control matter at the atomic and molecular levels with remarkable precision. This capability has led to significant advancements, particularly in nano-medicine and nanotechnology, which have dramatically altered the healthcare landscape over the past few decades.
The Relationship between Nanoparticles and Homeopathic Medicine: A Mini Review
Authors: S Sheeba , ST Gopukumar , SS Ramya , S Sanju , R Reghu , SJP Chenthik
Published: September 2024

Homeopathic medicine, rooted in the late 18th century by Samuel Hahnemann, operates on the principle of "like cures like" and involves administering highly diluted substances to treat symptoms. Despite its widespread use, homeopathy faces skepticism due to the extreme dilutions often beyond Avogadro's number, implying no molecules of the original substance remain. Recent advancements in nanotechnology suggest a potential role for nanoparticles in homeopathic remedies, bridging traditional practices and modern science. This mini-review explores the preparation of homeopathic remedies, which involves serial dilution and succussion, and presents evidence from a 2010 IIT Bombay study that detected nanoparticles in highly diluted homeopathic solutions. These findings challenge conventional views and propose potential mechanisms of action for homeopathic remedies, including biological interactions, energy transfer, and catalytic effects. While the presence of nanoparticles offers a plausible explanation for homeopathy's effects, the field remains controversial, necessitating rigorous, reproducible studies to validate these findings. This review highlights the integration of nanotechnology into homeopathic research, suggesting a promising path toward scientific acceptance and a deeper understanding of homeopathy's place in modern medicine.
Maternity care experiences and outcomes of people seeking sanctuary in Wales: a data linkage study protocol
Authors: Bukkfalvi-Cadotte Alix , Khanom Ashra , Brown Amy , Snooks Helen
Published: September 2024

IntroductionPeople seeking sanctuary, including refugees and asylum seekers, face barriers and challenges in accessing high quality healthcare. In maternity care specifically, asylum-seeking and refugee women are less likely to access timely and adequate antenatal care and may be more likely to experience adverse perinatal outcomes.
ObjectivesWe aim to describe maternity care service users seeking sanctuary in Wales and determine whether their perinatal health outcomes and use of maternity care services differ from women born in the UK.
MethodsWe will conduct a retrospective cohort study. Linking six datasets held by SAIL Databank, we will identify individuals recorded as refugees or asylum seekers in General Practitioner (GP) records. We will conduct a descriptive analysis of their demographic and health characteristics and conduct a comparative analysis of maternity care service use and perinatal health outcomes between refugees and asylum seekers and UK-born individuals. We will identify statistically significant differences between groups, and where the completeness and quality of the data allow, we will adjust for known covariates.
ResultsThis study will enable us to report on the characteristics of maternity care service users seeking sanctuary in Wales, their maternity care service use and perinatal health outcomes compared to UK-born women.
ConclusionsThis data linkage study will enhance our understanding of health inequities in maternity care and perinatal outcomes related to asylum seeker or refugee status. Results will inform policy and practice to improve provision of maternity care to women seeking sanctuary.
Utilization of Biscuit Waste in Poultry Diet- A Review
Authors: Patil Nilakshi Prakash , Sidhu Jujhar Singh , Hundal Jaspal Singh , Kaur Jasmine
Published: September 2024

Nowadays achieving sustainability and cost-effectiveness while providing sufficient nourishment for birds is a challenge faced by the poultry sector. Food waste is a global issue, involving fruits, vegetables, stale bread, pastries, biscuits, canned and baked foods, and expired dairy products. The surge in fast food and bakery consumption increases waste due to limited shelf life. These contributes to food wastage as well as pose disposal challenges and environmental concerns, which is a significant problem in a country like India where millions still lack access to adequate nutrition. Proper processing and management of bakery waste can reduce its burden by repurposing it as feed for monogastric animals like poultry. Among the bakery wastes, the biscuit waste typically incorporates carbohydrates, fats, and some protein making it a valuable ingredient for poultry feed. Biscuit waste can be utilized in feed formulations to supplement conventional ingredients through proper processing techniques like grinding, drying, pelletizing, and nutritional analysis. According to studies on poultry diets biscuit waste can save production costs, increase feed efficiency, and maintain or improve bird performance indicators including feed conversion ratio and weight gain. Utilizing biscuit waste for poultry feed helps to advance the circular economy principles by keeping waste out of landfills and lowering the environmental impact of the food and poultry industries. Overall, using biscuit waste into chicken feed can improve sustainability, resource efficiency, and economic viability by lowering food waste, preserving resources, minimizing the impact on the environment, and cutting production costs.
Analysis of Factors Affecting Inter-Provincial Inequality in Java
Authors: Murniati Neni , Gumelar Sandi Cahaya , Ramdaniatulfitri Intan
Published: September 2024

This study aims to determine the characteristics of all variables during the observation period, and determine the effect of all independent variables on the level of interprovincial inequality in Java through the panel data analysis method. This study uses the Williamson Index as a parameter of interprovincial inequality. The research observed on how per capita income, population, investment, open unemployment rate, and the Human Development Index (HDI) affect the level of interprovincial inequality in Java during 2010 – 2021. The results of the study show that during 2010 – 2021 the level of interprovincial inequality in Java tends to increase significantly. Judging from the level of inequality, sequentially there are 3 provinces in Java that have the highest level of inequality, namely DKI Jakarta, Central Java and West Java. On the other hand, partially the level of per capita income, population, open unemployment rate, and HDI have a significant effect on the level of interprovincial inequality in Java, but the level of investment has no significant effect on interprovincial inequality. It was also found that partially per capita income and HDI were the two variables that most influenced the level of interprovincial inequality in Java.
Performance Assessment Methodology of Occupational Health and Safety Management System
Authors:   RGU of Oil and Gas (NIU) named after I.M. Gubkin, Fomina E.E. , Kuzminova A.S. ,   RGU of Oil and Gas (NIU) named after I.M. Gubkin,   Transstroymekhanizatsiya LLC
Published: September 2024

Although occupational health and industrial safety management systems were implemented a while ago and are maintained at many enterprises globally, until now, no sufficient proof of the efficiency of such systems in terms of prevention and mitigation of the number of accidents, industrial accidents, and professional illnesses has been obtained. Therefore, further development and distribution of such systems depend on the ability to demonstrate their efficiency and performance, which can be achieved by implementing relevant methods and tools to stimulate the operational efficiency of their systems. Using expert assessment methods and mathematical processing of the results, eight mandatory and sufficient indices of performance of a functioning integrated system of an oil and gas company, whose main business activity is the production of petroleum products, have been identified. The company operates hazardous production facilities in Russia. The obtained indices describe the injury frequency, the level of employees’ training and their satisfaction with personal protection equipment, the nature of violations of safety requirements, and funding the events aiming to improve the integrated occupational health and industrial safety management system. Using the weighted average value of the established indices of system’s performance has been considered. Applying the Harrington’s desirability assessment method, the satisfactory level of performance of the existing integrated system has been determined. The integrated system performance assessment must be conducted by employer on an annual basis, which facilitates the development of effective corrective measures and the continuous improvement of the system. The established performance indices may change depending on strategical and tactical goals of the company. The proposed methodology of comprehensive quantitative assessment of integrated system can be used by employers in order to improve the existing management systems.
Occupational Risk Assessment at Workplace of a Driller’s Assistant Based on the Integrated Use of the Risk Matrix and the Board’s Calculation Method
Authors:   RGU of Oil and Gas (NIU) named after I.M. Gubkin, Karchina E.I. , Ivanova M.V. ,   RGU of Oil and Gas (NIU) named after I.M. Gubkin, Volokhina A.T. ,   RGU of Oil and Gas (NIU) named after I.M. Gubkin, Glebova E.V. ,   RGU of Oil and Gas (NIU) named after I.M. Gubkin
Published: September 2024

The study considers an example of identification of hazards and risk assessment at workplace of a driller’s assistant by using the risk matrix method based on the point assessment with the following application of the Board’s calculation method to rank hazards of the same or similar risk level by the degree of their criticality. The expert assessments of hazard ranking by the degree of criticality have been analyzed; the consistence of expert opinions has been determined. During the studies, the expert group composed a hazard register for 6105 workplaces in 24 branches of an enterprise of the fuel and energy industry based on the occupational safety instruction in accordance with types of jobs, occupations, job duties, statistical data on accidents occurred at the company, and the results of the special assessment of labor conditions. As an example, the article provides a hazard register for the workplace of a driller’s assistant. As the next stage, risk assessment for each identified hazard with the use of the matrix method 55 based on the point assessment, as stipulated in the Order of the Ministry of Labor and Social Protection of the Russian Federation of December 28, 2021, № 926 «On approval of the Recommendations on the selection of occupational risk level assessment methods and methods to reduce such risk levels», has been conducted. As the example shows, the risk level values are very close; for some hazards they are identical. In such a case, it is quite difficult to determine the risk criticality. In order to solve the problem, the Board’s calculation method has been suggested for the study. Using the Board’s calculation method, hazards whose risk was significant and the value of which was close or identical to other hazards have been ranked by their criticality degree. The expert assessment of hazard ranking by the degree of criticality has been analyzed; the expert opinions have been harmonized. The obtained data can be used for the development of measures to manage significant risks at the workplace of a driller’s assistant, including conditions of limited time and (or) funding resources.
The Effect of the Type of Organic Residues and the Level of Lead on the Growth of Yellow Corn mays Zea L.
Authors: Jasem Mohammed Ayat , Fakher Salwa Jumaa
Published: September 2024

For the purpose of studying the behavior of lead in the two study soils in Basrah Governorate, southern Iraq, soil samples were collected from two sites in Basrah Governorate (Al-Zubair and Kutayban) with different chemical and physical soil properties, and their content was estimated. Of total lead, a pot experiment was carried out that included growing the yellow corn crop (mays Zea L.) in pots filled with three kg of air-dry soil from the two study soils, treated with organic waste (cow waste and wheat straw waste) at a level of 0.40 tons ha−1. Then lead was added to the two study soils at a level of 0, 50, and 100 mg Pb kg−1 soil. The experiment continued for 60 days, after which plant growth measurements were taken, as well as the amount of total and ready lead remaining in the soil. The results of the study showed that adding lead at a level of 50 mg Pb kg−1 soil significantly increased the total lead concentration compared to the comparison treatment, and the Zubair soil was superior to the Kutayban soil in terms of dry weight and absorbed quantity. The levels of materials added from cow manure and wheat straw to the two soils of the study had a significant effect. In the concentration of lead compared to the comparison treatment, with the difference in the effect of the two substances, the cow manure 40 tons ha−1 outperformed the rest of the treatments and gave the highest growth characteristics, as the dry weight of the plant and the amount absorbed reached 8.806 mg pot−1 and 2.281 mg pot−1, respectively.
Motor Development in Cerebral Palsy and its Relationship to Intellectual Development: A Review Article
Authors: Twum Frank , Hayford Johnnie K.
Published: September 2024

This review article sought to ascertain how cerebral palsy affects the development and presentation of motor skills across the lifespan, as well as examine the relationship between motor skills and intellectual ability in individuals with cerebral palsy. Motor skills development in persons with cerebral palsy was discovered to be heterogeneous, with some individuals experiencing significant motor skills development while others encountered persistent challenges. The review further established that motor skill development may differ significantly across the different subtypes of cerebral palsy. Relative to the relationship between motor skills and intellectual ability, the review established both gross and fine motor skills may be predictive of intellectual ability in persons with cerebral palsy. In light of these findings, the review highlights the implications for educators and clinicians as well as the direction for future research.
Students' Perceptions of the Implementation of Learning at the Japan Internship Pusdiklat Batusangkar
Authors: Kemala Nina , Natsir MHD
Published: September 2024

The background of this research is the high perception of participants at LKP Yuko Tesa Mirai Padang because it is a special Japanese-language education and training center that provides opportunities for people who wish to have the opportunity to work abroad, especially Japan. This study aims to (1) describe the perceptions of the Batusangkar Japanese Intern Training Center participants towards the teaching staff, (2) describe the Batusangkar Japanese Intern Training Center participants' perceptions of the facilities, (3) describe the perceptions of the Batusangkar Japanese Intern Training Center participants towards learning media, (4) describe the participants' perceptions Japanese Intern Training Center Batusangkar on learning materials. This type of research is a descriptive quantitative approach. The population in this study were 28 people. The sampling technique used cluster random sampling of 20 people. Data collection techniques using a questionnaire. The data analysis technique uses the percentage technique to see the perceptions of the students of the Batusangkar Japanese Intern Training Center. The results of the conclusions of this study indicate that the perceptions of students from the Batusangkar Japanese Intern Training Center based on all indicators are categorized as good, this is evidenced by the high percentage in the always category.
Constructivism Thinking and Implementation in Non-Formal Education
Authors: Vendri Rivendri , Jamaris Jamaris , Setiawati Setiawati
Published: September 2024

Philosophy is a branch of science that has several realistic, fundamental aspects, values and knowledge that are fundamental in the birth of logical reasoning, critical thinking that discusses the universe, ethics, religion, life, knowledge and truth. In its development there are several schools of philosophy, one of which is the philosophy of constructivism, a thought where contructivism learning is seen as an active process that involves interaction between individuals and their environment. This concept can be applied in non-formal education in various ways. Constructivism thinking in non-formal education emphasizes the importance of active participation and meaningful learning for learners. This approach enables them to develop critical thinking, problem-solving and adaptability skills that are relevant in real life. The implementation of constructivism in non-formal education involves the important role of facilitators or teachers in creating an environment that encourages learners to actively participate and interact in the learning process. Teachers should apply methods that focus on learners, encourage critical thinking, and inspire them to formulate and analyze problems independently.Keywords: Philosophy, Thought, Constructivism, Non-formal education