bluuebunny/crossref_metadata_2025 huggingface dataset:
The Use of Assistive Technologies in Increasing the Participation of the Individuals with Severe and Multiple Disabilities to Leisure: Systematic Review
Authors: Çay Evgin , Bozak Burak
Published: December 2024

Leisure participation is one of the highly neglected areas. Supporting the leisure participation of the individuals with severe and multiple disabilities is important for them to be able to spend their leisure time in a quality and efficient way. In this study, the line of research through which assistive technologies have been used to increase the leisure participation of the individuals with severe and multiple disabilities have been examined. The studies in accordance with the criteria determined have been examined within the context of the published journal, used technology type, participant properties, used models and research findings. The examined studies have been scanned via electronic media using indexical scanning and then, manual scanning has been conducted on the basis of the references of the reached studies. 57 studies have been reached as a result of these scans. The studies reached have been assessed using the criteria determined by the authors. 12 studies meeting the criteria have been examined with descriptive analysis method. It has been seen when the study findings have been analyzed that the assistive technologies are efficient in increasing the leisure participation of the individuals with severe and multiple disabilities. Besides, when the studies in the scope have been examined, communication has been determined to be an important key for the participation of the individuals with severe and multiple disabilities to leisure activities. Communication based assistive technologies have been revealed to have a significant role in increasing the leisure participation. The obtained findings have been discussed in various contexts and suggestions have been made to the partners.
An investigation of technology-rich lesson plans: Science teachers’ views on technology integration
Authors: Gezer Murat , Durdu Levent
Published: December 2024

Numerous studies have extensively explored technology integration in instructional processes, covering learning outcomes, barriers, administrative support, and teachers' technological proficiency. However, limited research has specifically investigated teachers' perceptions of technology-rich instructional methods. This study involved a collaborative effort between a researcher and three science educators to develop technology-rich lesson plans. It aimed to investigate science teachers' perspectives on technology integration, encompassing aspects such as professional satisfaction, preparation time, provision of pre-designed lesson plans and materials, and preferences for technology-rich teaching approaches across distinct demographic variables. Utilizing a design-based research approach with a mixed-method design, this study employed a sequential triangulation model. The quantitative phase engaged sixty-three science teachers, complemented by a qualitative phase with three participants. Data collection methods included the Technology-rich Lesson Plan Evaluation Survey and semi-structured interviews. Teachers assessed three lesson plans for instructional appropriateness and technology integration dimensions. The Chi-Square test analyzed variations in teachers' opinions towards technology integration based on demographic characteristics such as gender, work experience, and self-reported computer competency. While not statistically significant, the results suggest that pre-designed technology-rich lesson plans positively impact professional satisfaction and reduce lesson preparation time. Teachers emphasized the necessity of providing such pre-designed lesson plans and materials for all learning outcomes, indicating a clear intention towards technology-rich teaching methodologies over traditional.
Evaluating the Sufficiency of Multiplicity Functions of Visual Cues in English Modules for Remote Learning: Perspective from Public Junior High School Teachers
Authors: Bañez Richard , Mosteyro Helen
Published: December 2024

This study aims to evaluate the sufficiency of visual cues in English modules and examine the adaptation practices of public junior high school teachers in utilizing these modules. Employing a descriptive-correlational research design, the study analyzed the relationship between the sufficiency of visual cues and the extent of teachers’ adaptation practices. Data were collected using a researcher-constructed survey instrument, validated and tested for reliability, and distributed to 70 junior high school English teachers in Tanauan City through an online platform. Statistical analyses, including mean, standard deviation, and Pearson Product-Moment Correlation, were employed to interpret the data. The findings revealed that visual cues in English modules were perceived as moderately sufficient, with teachers demonstrating a moderate extent of adaptation practices. A positive correlation was identified between the sufficiency of visual cues and the extent of adaptation practices which emphasizes their interconnected role in fostering effective teaching strategies. These results highlight the potential of well-designed visual cues and adaptive practices to enhance critical thinking and creativity among students by supporting more effective and inclusive learning experiences in diverse educational settings. This study calls for the implementation of professional development programs to enhance teachers’ competencies in adapting and integrating diverse, culturally responsive visual elements into their instructional practices to foster deeper student engagement and more meaningful learning outcomes.
Международные перевозки пассажиров и багажа: современное правовое регулирование
Authors: Мажорина Мария
Published: December 2024

Рецензия на кн.: Касаткина А.С. Договор перевозки пассажира и багажа в международном частном праве. Учебное пособие (М.: Юрлитинформ, 2014. 176 с.)
Дистанционная работа и схожие правоотношения
Authors: Закалюжная Наталья
Published: December 2024

Современное мировое пространство представляет собой новую реальность, которая преображает не только средства взаимодействия людей, но и воздействует на принципы организации производства и трудовые взаимоотношения. В условиях модернизации и глобализации экономики появляются нестандартные формы занятости. Исследование уже сформировавшихся юридических конструкций позволяет на их основе разработать нетипичные, отвечающие современным реалиям. При этом ряд нестандартных трудовых отношений уже продолжительное время функционирует в трудовом праве, и в то же время появляются все новые и новые нетрадиционные формы занятости. Современные методы организации делового сотрудничества и социальные коммуникации воздействуют и на сферу труда, вызвав появление новых эффективных форм занятости. Исходя из потребностей современного общества, важно сегодня учесть те изменения, которым подвергаются классические институты трудового права. Так, например, заключение трудовых договоров для выполнения конкретной работы на определенное время теперь уже не исключение, а правило. Новой эффективной формой занятости является дистанционная занятость, уже нашедшая законодательное регулирование в Российской Федерации. Модель дистанционной занятости устраняет существующие пробелы в регулировании нетипичных трудовых отношений. Сегодня важно обновлять российское трудовое право и приспосабливать его к процессу возникновения и развития новых трудовых отношений и форм организации труда. Правовой базой для этого могут в определенной степени послужить схожие правоотношения. Однако важно выявить правовую предысторию дистанционной занятости и признаки, отграничивающие ее от других схожих правовых явлений, послуживших в определенной степени прототипами телетруда. Поэтому в статье предпринята попытка анализа таких правоотношений, как режим рабочего времени, надомный труд (приводятся сходства и отличия надомного и дистанционного труда), место работы, самозанятость, работа по вызову (указывается на различные формы проявления данного труда), соглашения «ноль часов» (анализируется трудовой договор, лишенный всякого содержания), договор «минимум-максимум» (исследуется как договор, имеющий нижний и верхний предел рабочего времени) и др. Основой исследования являются нормы не только российского, но и зарубежного законодательства, в том числе и регионального, что вызвало необходимость использования критериев разграничения гражданско-правовых и трудовых правоотношений. В статье выделяются особенности дистанционной работы. Отмечается, что примеры дистанционного управления трудовыми ресурсами говорят о необходимости дальнейшей разработки положений о трудовой функции работника.
Examining Game Designs Compatible with the Planning, Implementation, Evaluation Model in the Context of Science Education
Authors: Yumak Sibel , Öçsoy Kübra , Öztürk Saliha , Benzer Elif
Published: December 2024

This study aims to examine the general features, quality, PIE (Planning, Implementation, Evaluation) model compliance, and environmental literacy of games created by pre-service science teachers using the PIE methodology. The research participants were pre-service science teachers who were enrolled in the elective course “Science, Sustainability and Environment (SSE)” as third-grade undergraduate students. The pre-service teachers were instructed to create a game using the PIE model while taking into account the environmental learning outcomes listed in the Ministry of National Education’s (MoNE) 2018 Science Curriculum. Three researchers assessed each of 13 designs independently, and reliability was determined using Miles and Huberman's formula (1994). The study's findings showed that the majority of the games were card games, and they were authentic. It was determined that the games met the PIE model's requirements for quality and compatibility. It was also established that the pre-service teachers primarily incorporated environmental awareness and subsequently knowledge in their games as part of the environmental literacy components.
Assessing the Pre-Service Science and Mathematics Teachers’ Systems Thinking Skills through Case Scenarios
Authors: Ceyhan Gaye Defne , Budak Ulku Seher , Karga Busra
Published: December 2024

Addressing complex global problems requires more comprehensive and holistic approaches that highlight the necessity of systems thinking skills; however, existing studies indicate a significant gap in understanding the systems thinking skills of pre-service teachers, emphasizing the need for further research in this area. This exploratory case study research explored the systems thinking skills of pre-service science and mathematics teachers through scenario-based assessments. Three case scenario examples focused on a specific aspect of systems thinking: stock-flow, causal-loop, and dynamic thinking. The participants of this study were 14 pre-service teachers taking a systems thinking course at the teacher education program of a public research university. The data were coded using the Systems Thinking Rubric and the Dynamic Thinking Skills Rubric. The results revealed that participants made notable improvements in dynamic thinking. However, fewer participants exhibited growth in stock-flow thinking comparing the participants’ disciplines, the results showed that pre-service science teachers demonstrated greater advancements in systems thinking skills than their mathematics counterparts. This exploratory research offers insights into assessing systems thinking skills in pre-service teachers. Integrating a systems thinking approach into teacher training programs could enhance teachers' preparedness to comprehend complex issues. Further studies employing systems thinking practices in teacher training programs could elucidate the optimal development of systems thinking among aspiring teachers. Therefore, this research demonstrates the potential of systems thinking to enrich pre-service teacher education.
Classroom Teachers' Opinions on Game-Based Assessment in Mathematics Lesson: A Phenomenological Research
Authors: Divrik Ramazan , Topal Hilal Nur
Published: December 2024

The study aims to gather the opinions of classroom teachers about the reflections of game-based assessment in mathematics lessons in primary school. The study followed a phenomenological design, which is one of the qualitative research methods. The participants consisted of eight classroom teachers working in public schools in Edirne and Kırklareli provinces in the 2023-2024 academic year. Participants were selected using convenience sampling, a type of purposive sampling method. The study data were collected using a semi-structured interview with six questions. The data were analyzed using content analysis. Based on the findings, game-based assessment was seen as a positive development. For teachers, it allowed long-term observation and monitoring of gains that turned into behaviors. For students, it fostered learning through fun, a desire to win, active participation, competition experience, and reduced exam stress. It also contributed to more enjoyable lessons and helped reduce negative perceptions of the subject. For teachers, challenges included the inability to make unbiased evaluations and low reliability. For students, negative aspects included lack of attention, focusing too much on fun, not following the rules of the game, and ignoring instructions. In terms of the mathematics lesson itself, issues included falling behind on the material and difficulty in creating games suitable for each learning objective. To address the challenges faced during game-based assessment in mathematics lessons, several strategies were suggested, including defining clear evaluation criteria, fostering cooperation and active participation, aligning objectives, following instructions, preparing a guideline, and ensuring material completion.
DBN-Based MPPT Algorithm with FOPID Control for Optimal Power Tracking, Reliability, and Efficiency in Solar PV Systems under Shaded Conditions
Authors: L Jenifer Suriya , J Christy Mano Raj
Published: December 2024

Monitoring the Maximum Power Point Tracking (MPPT) is one among the most crucial jobs in a solar system. Significant issues with solar power generation, including the installation and operation of PV panels, include harmonic distortion and electromagnetic radiation interference. As a result, the MPPT controller in the proposed work utilizes deep learning to track the MPP. Developing a Deep Belief Network (DBN) using the generated dataset allows it to determine the MPPT. Utilizing the Green Anaconda Optimization (GAO) based DBN to provide the reference or attained voltage, the fractional order controller is then used to generate the converter’s pulse. The suggested methods outperform prior MPPT methods in terms of steady state response, oscillation-free operation, loss reduction, and time to settle down at MPP. The suggested model provides very low harmonic values, such as 0.78% for voltage THD and 0.781% for current THD, and accuracy of 99.8%. The outcomes show that, the optimal DBN MPPT approach works better than the controllers.
Study on Reliability of Field-Aged Photovoltaic
Connectors
Authors: Kapoor Kartik , Muthusamy Eswaramoorthy , Goyal Devendra , PG Nikhil
Published: December 2024

The paper presents the reliability study on field-aged photovoltaic connectors of different makes characterized by diverse climatic conditions with 2 to 10 years of operational life. A series of tests conforming to IEC 62852 conducted on field-aged connectors and control samples. The objective is to elucidate the mechanisms of aging and evaluate reliability of connectors, identify failure modes, potential hazards, changes in electrical and mechanical performance because of longstanding exposure to environmental and operational stresses. Field survey and testing reveal lack of awareness of workmanship and maintenance. Laboratory testing reveals connector less than 6 years of life shows low contact resistance and remain stable or have marginal linear increase after thermal and damp heat testing. Samples with life of 6 years or more from extreme climatic regions show high contact resistance with nonlinear pattern increasing to 300% in the thermal cycle and up to 600% in damp heat test. In SEM fretting was observed with high contact resistance with marginal polymer deterioration
Öğretmence Metaverse: İlkokul Öğretmenlerinin Metaverse ile İlgili Bilişsel Yapısı
Authors: Kaya Fatih , Şan İsmail
Published: December 2024

Öğretmenlerin, eğitimde kullanımının yaygınlaşması beklenen metaverse ile ilgili algıları, günümüz neslinin metaverse’e yönelik tutumunu etkileyebilir. Bu araştırmanın temel amacı, sınıf öğretmenlerinin metaverse’e ilişkin bilişsel yapılarını ortaya çıkarmaktır. Bu çalışma, nitel araştırma yöntemlerinden olgubilim deseninde tasarlanmıştır. Araştırmanın katılımcılarını, Malatya ilinde 2023-2024 Eğitim-öğretim yılında devlet okullarda çalışan 42 sınıf öğretmeni oluşturmaktadır. Katılımcıların belirlenmesinde, uygun örnekleme yöntemi ve kartopu örnekleme yöntemi kullanılmıştır. Araştırmanın verileri, kelime ilişkilendirme testi ile toplanmıştır. Katılımcılar, metaverse kavramını 183 kelime ile ilişkilendirmişlerdir. Araştırma verilerinin analizinde, içerik analizinden faydalanılmıştır. İlişkilendirilen kelimelerin frekansları belirlenmiş, kesme noktaları belirlenerek kavram ağında gösterilmiştir. Yapılan analizler neticesinde; “metaverse yapısı”, “ekonomik düzen”, “internetin evrimi”, “metaverse teknolojileri”, “eğitim”, “olası tehlikeler”, “uzay” ve “sosyal metaverse” temalarına ulaşılmıştır. Eğitimin salt sanal ve dijital bir ortama evrilmesindense, metaverse teknolojilerinin eğitime hibrit model ile entegre edilmesinin daha doğru olacağı düşünülmektedir.
Sesli Okuma Uygulamalarının 8. Sınıf Öğrencilerinin Okuduğunu Anlama Yeterlikleri Üzerindeki Etkisi
Authors: Uğurlu İlknur , Emiroğlu Selim
Published: December 2024

Sesli okuma uygulamalarının 8. sınıf öğrencilerinin okuduğunu anlama yeterlikleri üzerindeki etkisinin metin türlerine ve cinsiyete göre değişkenlik gösterip göstermediğinin incelendiği bu çalışma, nitel araştırma yöntemlerinden durum çalışmasının bütüncül çoklu durum deseni ile gerçekleştirilmiştir. Çalışmanın örneklemini 2023-2024 eğitim-öğretim yılında İstanbul ili Küçükçekmece ilçesinde resmî bir ortaokulda öğrenim gören 8. sınıf öğrencileri oluşturmaktadır. Çalışmada, öğrencilerin daha önce bilmedikleri/okumadıkları bir metin olması yönüyle eski yıllarda kullanılan Türkçe ders kitaplarındaki 36 serbest okuma metni incelenmiş ve bunlardan bilgilendirici, şiir ve hikâye kategorisinde olmak üzere üç farklı türde metin belirlenmiştir. Metinler, akademik başarıları birbirine denk olan sınıf/şubelerde farklı sesli okuma uygulamalarıyla okunmuş/okutulmuş, okumalar kayıt altına alınmış, okumalar bittikten sonra öğrencilere araştırmacı tarafından uzman görüşleri doğrultusunda geliştirilen okuma anlama sınavları uygulanmıştır. Yapılan okuma anlama sınavlarının sonuçları SPSS-23 programı aracılığıyla analiz edilmiştir. Elde edilen bulgular betimlenerek metin türü ve cinsiyete göre sınıflandırılmış, sesli okuma uygulamaları kıyaslanarak sunulmuştur. Çalışmanın sonuçları ışığında, metin işleme sürecinde sesli okuma uygulamalarının belirlenmesinde bir sistemin olabileceği düşüncesine ulaşılmıştır. Sesli okuma uygulamalarının kullanımı ve çeşitlendirilmesinin cinsiyet ve metin türleri değişkenleri ve okuduğunu anlama üzerinde etkili olduğu sonucuna ulaşılmıştır. Çalışmada kullanılan sesli okuma uygulamalarının okuduğunu anlama üzerindeki etkililik düzeyi sırasıyla; rastgele seçilen öğrencilerin, belirlenen öğrencilerin, belirlenen bir öğrencinin ve öğretmenin metni sesli okuması biçimindedir. Çalışmada elde edilen sonuçlardan hareketle öneriler sıralanmıştır.
THE RELATIONSHIP BETWEEN CIVIC IDENTITY AND HARDINESS OF UKRAINIAN STUDENT YOUTH
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Sosniuk O. P. , Baratiuk O. O. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: December 2024

This article is devoted to analysis of connection between civic identity and hardiness of Ukrainian student youth. According to the results of empiric research authors have defined the peculiarities of civic self-identification, civic competence and hardiness of students.
It was determined, that the most prevalent types of civic identity among the researched are latent and communitarian, less distributed, but salient - institutionally-gamified and communitarially-gamified.
Statistically significant positive correlations between hardiness and different aspects of civic competence, such as responsibility, attitudes, skills and abilities, participation and knowledge were discovered. The highest correlation was found between hardiness and civiс participation.
Distinctions between manifestations of civic competences of youth were discovered. Indicators on scales of civic attitudes, social connections and civic participation are statistically higher for students, who are temporarily displaced, in comparison with students, who remain at permanent place of residence.
The existence of statistically significant relationship between collectivist orientation and hardiness was found.
Statistically significant correlations between indicators of hardiness, level of maturity, and type of civic identity were established. Hardiness has positive correlations with maturity of civic competence, subject orientation, conceptuality, cognitive, value-based, and behavioral engagement. It was determined, that students, who have communitarian type of civic identity have significantly higher level of hardiness, in comparison with students, who have latent type of civic identity.
It was discovered, that subject orientations, civic skills and abilities, collectivism, personal competence, social responsibility and types of civic identity (institutionally-gamified, latent, communitarian, communitarially-gamified) predictors act as predictors of hardiness of Ukrainian student youth.
PSYCHOLOGICAL CHARACTERISTICS OF AN INDIVIDUAL’S ADDICTION DEPENDING ON THE INFLUENCE OF MODERN INFORMATION TECHNOLOGIES
Authors:   K. D. Ushynsky South Ukrainian National Pedagogical University, Odesa, Ukraine, Maksymenko Y. B. , Murmanova I. М. ,   K. D. Ushynsky South Ukrainian National Pedagogical University, Odesa, Ukraine
Published: December 2024

The article presents the empirical study on the psychological characteristics of addiction developed under the influence of modern information technologies. «Addiction developed under the influence of modern information technologies» means a condition characterized by subjective mediation of activities with exaggerated, active and long-term use of IT-tools that can lead to loss of control over life and appearance of social, professional and personal problems. This condition manifests itself in various forms, such as addiction to the Internet, video games, social networks, smartphones, etc. and via various symptoms, such as disinterest in real life, anxiety and stress without access to IT-tools, loss of control, etc. People with such addiction experience changes in their consciousness under the Internet influence, perceive that this network is more attractive than real life; they limit their interaction mainly to online communication.
This affects the duration, as well as the variety of activities in the Internet; it is perceived as projective reality; a desire appears to subjugate the real world to the norms inherent in the virtual environment. Such people have high motivation and efficiency in the use of information technologies, but at the same time, they have some difficulties in controlling their emotions while using the Internet. It is proved that their personal traits (low self- esteem, impulsivity, isolation, frustration, uncertainty about innovations, etc.) create psychological conditions for increasing dependence on modern information technologies. Psychologically, the respondents having high dependence on modern information technologies are characterized by high motivation to use IT-resources, wide online communications, a tendency to long-term interactions in the network subculture, perception of the Internet as an important part of subjective reality, awareness of IT-tools using, limited ability to control emotions, low self-esteem, impulsivity, isolation, frustration, uncertainty and radicalism.
Güvenlik Çalışmaları Alanının Mevcut Durumu ve Geleceği Üzerine Bir Değerlendirme
Authors: Özgür Erdem , Yılmaz Murat
Published: December 2024

Güvenlik, disiplinler arası nitelikte bir çalışma alanıdır. Güvenlik konusunda her geçen gün genişleyen perspektifle bilgi üretilmekte ve ilgili çalışmaların sayısı artmaktadır. Bu durum, “Güvenlik çalışmaları başlı başına bir bilim dalı/disiplin olarak değerlendirilebilir mi?” sorusunun irdelenmesini isabetli kılmaktadır. Bu bağlamda makale, bilim alanı ölçütleri bağlamında Türkiye'deki güvenlik çalışmalarının mevcut durumunu ve bir disiplin olarak konumunu tartışmaktadır. Güvenlik çalışmaları; ayrı bir literatüre sahip olma, belirli araştırma soruları ve metodolojisi oluşturma, eğitim programlarına konu olma, akademik bir topluluk oluşturma ve kurumsallaşma-akademik örgütlenme açısından ele alınmıştır. Buna koşut, güvenlik alanında Türkiye’de üretilen lisansüstü çalışmaların ilişkilendirildikleri konular, güvenlik çalışmalarının disipliner pozisyonunu saptamak açısından incelenmiştir. Ayrıca Üniversitelerarası Kurul (ÜAK) ve Yükseköğretim Kurumu’nun (YÖK) güvenliğin bilim alanı olarak değerlendirilmesine yönelik çalışmaları ile birlikte Türkiye Yükseköğretim Yeterlilikler Çerçevesi (TYYÇ) kapsamında eğitim-öğretim alanlarının sınıflandırmasına yönelik yapılan çalışmalar değerlendirilmiştir. Nihayetinde güvenlik çalışmalarının bir bilim alanı olarak kategorilendirilmesine ve akademik düzeyde örgütlenmesine yönelik öneriler sunulmuştur.
Enhancing Currency, Commodity and Energy Price Forecasting Using the LSTM Model: A Case Study of EUR/NZD, GAS and SUGAR Prices
Authors: Alwesh Bashir , Türk Fuat , Kılıçaslan Mahmut
Published: December 2024

Forecasts from machine and deep learning models are vital for traders and investors in the global financial markets. Many different forecasting methods rely on technical patterns. In this study, the LSTM model based on candlesticks and financial variables was used to improve trading forecasts of different types. Japanese candlesticks are among the most widely used tools for evaluating financial markets. Therefore, these candlesticks, which show price patterns and differences between buying and selling, provide important data for predicting future price fluctuations. A 15-minute candlestick or 15-minute frame is used. The model showed excellent performance in predicting currency rates (EUR/NZDUSD), with an accuracy based on mean square error (MSE = 1.377e-07). The model also showed better accuracy in predicting sugar prices compared to other models, reaching (MSE = 1.419836). The same results were obtained with the GAS model, where the value was (MSE = 0.000173). This superior performance of the model indicates its ability to generate historical patterns and use them effectively in forecasting financial markets. These results provide promising opportunities for traders and investors to make more guided and intelligent investment decisions based on future trends based on these patterns. By using historical patterns and financial data, LSTM's deep learning model shows exceptional predictive performance. It outperforms traditional machine learning methods such as XGBoost. XGBoost achieved a score on the EUR/NZDUSD exchange rate (MSE = 9.537e-07). The error rate for the presented model is considered to be high. This confirms the success of the represented approach and its ability to enable traders and investors to make more informed and strategic decisions. This ultimately contributes to improving trading conditions and investment outcomes in global financial markets.
Intrusion Detection and Performance Analysis Using Copula Functions
Authors: Burukanlı Mehmet , Çıbuk Musa
Published: December 2024

Nowadays, interest in technology is growing as technology advances and makes our jobs easier. These rapid technological advancements bring with them a slew of unwanted negative attacks, such as cyber-attacks and unauthorized access. To prevent such negative attacks, intrusion detection systems are frequently used. In this research, we make some suggestions for novel and reliable classifiers for intrusion detection systems that are based on copulas. Using copula-based classifiers, we hope to detect intrusion in computer networks. Student's-t, Gumbel, Clayton, Gaussian, Independent and Frank classifiers, which are frequently used in the literature, have been preferred as copula-based classifiers. These classifiers were used to perform classification on the KDD'99 dataset. The 10-fold cross-validation method has been used in the classification phase. When the experimental results were examined, the proposed Gaussian copula-based classifier outperformed state-of-the-art basic methods on the KDD'99 dataset with a success rate of 99.41%. As a direct consequence of this, classifiers based on the copula have shown promising results in the field of intrusion detection. Classifiers that are based on the copula have been found to be a competitive alternative to the most recent and cutting-edge fundamental approaches.
Pharmacokinetics of pertuzumab biosimilar compared with the original drug in cynomolgus monkeys
Authors: Podolyakina Anna I. , Dmitrieva Anastasia A. , Postnikova Victoria A. , Konstantinova Anastasia A. , Petkova Anna V. , Trashkov Alexander P. , Shamsutdinova Olga A. , Terenteva Daria A. , Dubatovka Elizaveta , Shipaeva Elena V. , Filon Olga V. , Samsonov Mikhail Yu. , Ignatiev Vasily G.
Published: December 2024

BACKGROUND: Developing biosimilar monoclonal antibodies for treating malignant diseases is a critical task. RPH-051 (pertuzumab) is a biosimilar drug, a recombinant humanized monoclonal antibody targeting type 2 human epidermal growth factor receptors. At the stage of non-clinical development, studies of pharmacokinetics of biosimilar vs. original drug product in a relevant animal species, provide important information on the comparability of drugs.
AIM: To evaluate the pharmacokinetics of the biosimilar product RPH-051 in comparison with the original drug after a single intravenous injection in a cynomolgus monkey model.
MATERIALS AND METHODS: The study was conducted in 8 cynomolgus monkeys (Macaca fascicularis) divided into 2 groups, each including 2 females and 2 males. The first group received the biosimilar RPH-051 (international nonproprietary name is pertuzumab, AO R-Pharm, Russia), the second group was treated with the comparator Perjeta® (international nonproprietary name is pertuzumab). The drugs were administered as a single intravenous dose of 50 mg/kg. Blood samples were collected before dosing, then at 1 min, 1, 2, 4, 8, 24 h, and on days 3, 7, 10, 14, 21 and 28 post-dosing. Quantitative analysis of pertuzumab serum levels was performed using enzyme-linked immunosorbent assay (ELISA) with spectrophotometric detection in the visible range of the spectrum.
RESULTS: The method of quantitative assessment of serum level of pertuzumab using (ELISA) in cynomolgus monkeys was developed. The method was validated against the following parameters: selectivity, minimum required dilution, lower limit of quantification, calibration range, accuracy and precision (within the analytical run and between runs), specificity, linearity (possibility) of sample dilution, parallelism, and stability of the analyte in serum.
Comparability of the drugs in the main pharmacokinetic parameters was established. The mean Cmax and AUClast values of RPH-051 and of the comparator were 1684.34 and 1405.34 μg/mL (Cmax); 265,282.18 and 280,168.92 (μg/mL)×h (AUClast), respectively.
CONCLUSION: Comparability between the pharmacokinetic profiles of the biosimilar RPH-051 and the originator’s drug was demonstrated. In the course of the study, no adverse clinical events, animal body weight changes, or injection site reactions associated with the tested drugs were observed.
Comparative evaluation of antitumor effects of methionine-γ-lyase in in vitro 2D and 3D human tumor models
Authors: Karshieva Saida Sh. , Demidova Elena A. , Spirina Tatyana S. , Babaeva Gulalek A. , Bondarev Nikolay A. , Bazhenov Sergey V. , Manukhov Ilya V. , Pokrovsky Vadim S.
Published: December 2024

BACKGROUND: Promising antitumor drug screening results obtained from monolayer cultures are often poorly reproduced in the in vivo models. Using clinically relevant 3D in vitro human tumor models, such as spheroids, provides a more reliable framework for evaluating antitumor activity. This is particularly important when the drug’s mechanism of action targets cellular metabolism.
AIM: To conduct a comparative study of the antitumor activity of methionine-γ-lyase (MGL) in 2D and 3D human tumor models.
MATERIALS AND METHODS: Human fibroblast cell culture and tumor cell lines, e.g. MCF7 human breast cancer, HCT-116 colorectal cancer, PANC-1 human pancreatic cancer, Huh7 liver cancer, and LNCaP human prostate cancer were used to evaluate MGL cytotoxicity. Cultural plates with low-adhesive coating were used to produce the spheroids. Cell survival was assessed using the resazurin test.
RESULTS: The spheroid model showed higher cell survival after 72-hour MGL exposure compared with the monolayer culture model in all tested cultures. Fibroblasts demonstrated the lowest sensitivity to MGL exposure in both 2D and 3D culture models, with IC50=2.2 and 9.1 IU/mL, respectively. The rapidly proliferating PANC-1 and HCT-116 cells showed the highest sensitivity to MGL in 2D and 3D models: IC50=0.23 and 1.5 IU/mL; IC50=0.83 and 1.43 IU/mL, respectively.
CONCLUSION: The effect of MGL on cell survival in the spheroid systems is less pronounced than in monolayers. The viability of cells exposed to survival MGL in the spheroid culture system is independent of spheroid size or growth rate. Despite the maximum cytotoxic effect being observed in the fast-growing spheroid model of colon cancer HCT-116, and the lowest in the model of slowly dividing fibroblasts, this dependence was not so obvious for other cell types. Overall, the spheroid model has proven useful for testing the specific activity of enzyme-based antitumor drugs, as far as it overcomes the excessive intrinsic sensitivity observed in monolayer cancer models.
In vivo antitumor effects of bis-benzimidazole derivatives in mouse melanoma and lung cancer models
Authors: Karshieva Saida Sh. , Arutuynyan Albert F. , Zaitseva Elizaveta A. , Smirnov Nikolay M. , Zhuze Alexey L. , Susova Olga Yu.
Published: December 2024

BACKGROUND: The development of new antitumor agents on the basis of benzimidazoles opens new opportunities for treatment of the malignant tumors, including those refractory to conventional therapies. The benzimidazole derivatives demonstrate wide spectrum of biological activities, specifically antineoplastic effects, and high-level cytotoxicity toward human’s tumor cell lines. The exploration of antineoplastic effects of new synthetic benzimidazole derivatives in in vivo models of tumor growth will help the development of the effective doses and cancer treatment regimens with the use of such compounds.
AIM: To assess the antineoplastic effects of the benzimidazole derivatives — monomeric compound MB2Py(Ac) and dimeric compound DB2Py(3) — in the continuous cellular models of Lewis lung carcinoma (LLC) and melanoma B16 in mice.
MATERIALS AND METHODS: In vivo assessment of antineoplastic effects was performed in the continuous mouse models of Lewis lung carcinoma (LLC) and B16 melanoma after a single intravenous injection of MB2Py(Ac) and DB2Py(3). Irinotecan was used as a comparator drug. Antitumor effects were measured via standard parameters, such as tumor growth inhibition (TGI%) and tumor growth rate (TGR).
RESULTS: The study compounds DB2Py(3) and MB2Py(Ac) used in the study doses and regimen demonstrated mild antitumor effect in the model of murine solid tumors (TGI 50%). In melanoma B16 model, the maximum tumor growth inhibition was 15% and 38.5%, respectively, for MB2Py(Ac) and DB2Py(3). In the lung carcinoma model, the mild effect was observed, e.g. 8% for MB2Py(Ac) and 23.4% for DB2Py(3). The effect of the comparator drug, irinotecan, was more expressive, although short-term. In particular, TGI achieved 52.5% for melanoma B16 and 34.5% for Lewis lung carcinoma (LLC). In general, melanoma B16 was more sensitive to the effects of both bis-benzimidazoles and irinotecan, compared to the lung carcinoma LLC.
CONCLUSION: This study shows that the dimeric compound DB2Py(3) was the most promising among three study substances in the models of melanoma and lung carcinoma in mice. Nevertheless, its high toxicity imposes the necessity of further optimization for the clinical use. The substance MB2Py(Ac) demonstrated lowest efficacy, although it may be also explored in the modified treatment regimens.
Successful management of lamotrigine-associated skin rashes in an adolescent girl with autism and bipolar disorder
Authors: Göksu Zeynep Kübra , Karayağmurlu Ali
Published: December 2024

Lamotrigine, an antiepileptic class drug, is an agent that can be used as a mood stabilizer in children and adolescents and skin rashes as a side effect are seen. Rarely, Stevens Johnson Syndrome may develop with skin rashes that may be mortal accompanied by systemic symptoms. In this paper, lamotrigine was started as a mood stabilizer in addition to the current olanzapine treatment in an 18 years old adolescent girl with autism spectrum disorderand bipolar disorder type 2. After the dose was increased, erythematous acneiform rash developed on the 10th day. Then, lamotrigine was discontinued and skin rashes regressed. Slowly titrating lamotrigine dose, noticing skin rashes on treatment and be able to distunguish bening and malign rash are so helpful for clinicians. An 18 years old adolescent girl who was followed up with the diagnosis of autism spectrum disorder and bipolar disorder was started on lamotrigine as a mood stabilizer in addition to the current olanzapine treatment. On the 10th day of treatment, erythematous acneiform skin rashes appeared on the face. After the dermatology consultation response, the drug was discontinued and the skin rashes regressed within 1 week.
The fact that the skin rashes appeared in the head-neck region, were mildly painful, tended to coalesce, and resolved when the drug was discontinued, suggested that might be malign rash. The absence of systemic symptoms, intact blood values and no additional treatment is required, suggested that might be benign rash. Further studies are needed on the use of lamotrigine in children and adolescents with autism spectrum disorder.
Penoscrotal abscess originating from the corpus spongiosum
Authors: Bozer Ahmet
Published: December 2024

Öz:
Amaç: Bu çalışmanın amacı, koroner arter hastalığı, serebrovasküler olay ve hipertansiyon öyküsü olan 89 yaşındaki bir erkek hastada corpus spongiosumdan orijin alan penoskrotal apse olgusunu sunarak, nadir görülen bu durumun tanı ve tedavi yöntemlerini değerlendirmektir.
Gereç ve Yöntem: Çalışmada kullanılan gereçler, hastanın klinik öyküsü, muayene bulguları, skrotal ultrasonografi, skrotal manyetik rezonans görüntüleme (MRG), laboratuvar sonuçları ve uygulanan tedavi yöntemlerini içermektedir.
Bulgular: Klinik muayenede üretral meatal stenoz ve posterior skrotal şişlik ile ele gelen kitle saptandı. Skrotal ultrasonografide hastanın uyumsuzluğu ve prosedürel kısıtlamalar nedeniyle lezyon demonstre edilemedi. Daha sonra, skrotal manyetik rezonans görüntüleme (MRG) yapıldı ve korpus spongiosumdan kaynaklanan, skrotum ve perineye uzanan, artmış vaskülarite ve karakteristik görüntüleme özellikleri olan multiloküler bir koleksiyon izlendi. Laboratuvar bulguları beyaz kan hücresi sayısında ve C-reaktif protein seviyelerinde yükselme izlendi. Hastaya periüretral apse tanısı konmuş ve 10 günlük sefiksim kürü ile başarılı bir şekilde tedavi edilerek drenaja gerek kalmadan tam gerileme sağlanmıştır.
Sonuç: Bu vaka, nadir görülen penoskrotal apselerin tanı ve tedavisinde hızlı ve hedefe yönelik müdahalenin önemini vurgulamaktadır. Ayrıca, üretral meatal stenoz gibi predispozan faktörlerin tanınmasının önemini vurgulamaktadır.
Comment on “Plasma kallistatin levels in patients with COVID-19”
Authors: Daungsupawong Hinpetchdaung , Wiwanitkit Viroj
Published: December 2024

Comment on plasma kallistatin levels in patients with COVID-19
Comment on plasma kallistatin levels in patients with COVID-19
Comment on plasma kallistatin levels in patients with COVID-19
Comment on plasma kallistatin levels in patients with COVID-19
A rare cause of acute abdomen in children: a torsioned giant mature cystic teratoma in an 11-year-old girl
Authors: Uysal Mehmet
Published: December 2024

Ovarian torsion, which is an uncommon cause of abdominal pain, is usually caused by dermoid and benign functional cysts in pre-menarcheal girls. Therefore, their diagnosis is difficult, as seen in this case. This case is the case of an 11-year-old pre-menarcheal girl who was admitted to our hospital due to abdominal pain and bilious vomiting. During the abdominal examination of the patient, who was in the premenstrual period, she had abdominal pain in both lower quadrants. There was significant tenderness. During rectal examination, a perirectal mass was palpated on the right. Leukocyte count (17,000 /mm³) and tumor markers AFP and beta HCG were at normal levels. Ultrasonography (US) showed a peripherally located, hard lesion with millimetric cystic areas, 12x9x8 cm in size, with a heterogeneous internal structure, in the right ovary region. During the surgery, serohemorrhagic fluid was detected in the abdomen and 720° clockwise right adnexal torsion was detected. The right ovary was deformed. A sample was taken with a syringe for cytology. The mass in the right ovary was approximately 12x9x8 cm in size and contained cystic and solid components. There were necrotic and occasionally hemorrhagic areas in the right ovary and fimbria. Due to the gangrenous appearance of the ovary, a right salpingo-oophorectomy was performed. The patient was discharged with recommendations on the 5th postoperative day. Surgical intervention should be performed early to reduce the risk to the patient's future fertility. In this way, we can prevent losing the ovary after infarction that occurs after ischemia and necrosis.
Dramatic improvement with superficial temporal artery and middle cerebral artery bypass in acute ischemic stroke in a rural area without MRI and angiography
Authors: Eser Taha , Hastürk Aşkın Esen
Published: December 2024

Stroke is a major cause of mortality and morbidity. The best therapeutic modality is the early identification of patients with stroke symptoms, correct interpretation of different neuroimaging techniques, and immediate provision of reperfusion therapy. Apart from conventional treatments, superficial temporal artery-middle cerebral artery (STA-MCA) bypass should be considered a treatment modality for acute ischemic stroke, with good results and early improvement in cerebral perfusion and neurological status. In the present case, in a patient clinically diagnosed with MCA infarction, early STA-MCA bypass 45 min after symptom onset resulted in rapid neurological recovery, and contrast-enhanced computed tomography showed that the anastomosis was functioning.
Evaluation of neurofilament light chain levels in multiple sclerosis during acute attack periods
Authors: Sarıteke Alp , Öcek Levent , Karakoyun İnanç , Çolak Ayfer , Şener Ufuk
Published: December 2024

Purpose: The aim of this study is to evaluate how the serum neurofilament light chain (sNfL) was influenced in the multiple sclerosis (MS) patients before and after treatment of an acute attacks, and to determine the relationship of it with clinical findings.
Materials and Methods: Thirty eight patients with a definite diagnosis of relapsing-remitting MS (RRMS) and who had a clinical acute attack between December 2019 and November 2020 were included in the study. The sNfL levels were studied before and after the treatment of an acute attacks. The relationship of sNfL levels with the patients’ clinical characteristics and treatment of acute attack was analyzed.
Results: The sNfL levels of a total of 38 RRMS patients were evaluated. The mean age of the patients were 35.8 ± 9.68 years (19-55 years). The sNfL level before and after treatment of acute attack were 3.55 pg/mL (3.09-4.54 pg/mL) and 3.36 pg/mL (3.01-3.86 pg/mL), respectively. No statistically significant difference was found between the sNfL levels before and after treatment. Likewise, no relationship between the before and after treatment sNfL levels with clinical findings such as gender, age, duration of disease, and biochemical findings were detected.
Conclusion: In our study, we found that the sNfL level, which is a biomarker of the prognosis and neuronal degeneration in the long-term, did not influenced by the high dose corticosteroid treatment.
Markers of inflammation in patients with generalized anxiety disorder
Authors: Yıldız Sevler , Kazğan Kılıçaslan Aslı , Sırlıer Emir Burcu , Tabara Muhammed Fatih , Kurt Osman , Sehlikoğlu Şeyma , Uğur Kerim
Published: December 2024

Purpose: The aim of this study was to analyze the systemic immune response index, systemic immune inflammation index, neutrophil/HDL, lymphocyte/HDL, platelet/HDL, and monocyte/HDL ratio, used as inflammatory markers in patients with generalized anxiety disorder (GAD).
Materials and Methods: A total of 864 participants, including 432 healthy controls and 432 patients diagnosed with GAD, were included in this study. High-density lipoprotein (HDL-c) levels, neutrophil, monocyte, lymphocyte, and platelet counts; systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), neutrophil/high-density lipoprotein ratio (NHR), lymphocyte/high-density lipoprotein ratio (LHR), monocyte/high-density lipoprotein ratio (MHR), and platelet/high-density lipoprotein ratio (PHR) were calculated.
Results: The median age of the case group was 35.50 (interquartile range: 28.00-44.00), while the median age of the control group was 35.00 (interquartile range: 28.00-44.00). In the GAD group, neutrophils, monocytes, SII, SIRI, NHR, LHR, MHR, and PHR were significantly higher, while platelets and HDL were significantly lower.
Conclusions: This study highlights that elevated systemic inflammation markers, such as SII and SIRI, along with altered HDL ratios, may be associated with GAD. The findings support the hypothesis that inflammation plays a role in the etiopathogenesis of GAD, potentially contributing to both diagnosis and management.
Serum leukocyte cell-derived chemotaxin-2 (Lect-2) levels in osteoarthritis patients
Authors: Kılıç Adil Furkan , Baygutalp Fatih , Şahin Mestan , Duysak Lale , Bayraktutan Zafer , Kuralay Yunus
Published: December 2024

Purpose: An association between the complimentary system and osteoarthritis is becoming more apparent. Lect-2 protein acts as a regulator of immunological and inflammatory responses. This study aims to determine the levels of leukocyte cell-derived chemotaxin-2 (Lect-2) in patients with osteoarthritis.
Materials and Methods: The study included 38 osteoarthritis patients and 36 healthy controls. ESR, WBC, serum CRP and Lect-2 levels were measured both in patients and controls.
Results: ESR and serum CRP levels were significantly higher in patients compared to controls. The mean Lect-2 level in osteoarthritis patients (14.2±4.8 ng/mL) was significantly lower compared to the healthy control group (56.3±20.7 ng/mL). ROC analysis revealed that serum LECT-2 level was a significant parameter in determining patients from healthy controls. Cut off value was ≤24.8 ng/mL with a high AUC (0.990).
Conclusion: The significant reduction in Lect-2 levels in osteoarthritis patients suggests its potential role in disease pathogenesis. This finding may contribute to understanding the immunological aspects of osteoarthritis and could potentially serve as a biomarker for disease progression. Further studies with larger patient populations are needed to validate these findings and explore the therapeutic implications of Lect-2 in osteoarthritis management.