bluuebunny/crossref_metadata_2025 huggingface dataset:
Placement of Plastic Stents after Direct Endoscopic Necrosectomy through a Novel Lumen-Apposing Metal Stent for Effective Treatment of Laterally Extended Walled-Off Necrosis: A Pilot Study
Authors: Lee Kyong Joo , Park Se Woo , Park Da Hae , Kim Jung Hee , Jung Jang Han , Koh Dong Hee , Lee Jin , Kim Mi Gang
Published: February 2023

Direct endoscopic necrosectomy (DEN) using a lumen-apposing metal stent (LAMS) is a standard therapy for the management of symptomatic walled-off necrosis (WON). Here, we demonstrated the efficacy of the routine placement of long plastic stents after a DEN session to treat laterally extended WON. Patients (n = 6) with symptomatic laterally extended WON who underwent DEN after long plastic stent placement were included. The primary endpoint was clinical efficacy of the procedure. The technical and clinical success rates were 100% without major adverse events. The WON extended to the pelvic cavity or pericolic area, and the WON size was between 18.6 and 35.8 cm in length. The median number of DEN sessions was 10 (range 6–16), and two or three long plastic stents were placed after every DEN session. Only one patient suffered from pneumoperitoneum during DEN, which spontaneously resolved within 20 min. Placement of a long plastic stent after DEN using LAMS is a minimally invasive and effective treatment for symptomatic laterally extended WON. Further studies are needed to define the indications and most suitable patients.
Quality of Life and Post-Surgical Complications in Patients on Chronic Antiplatelet Therapy with Proximal Femur Fracture: 12-Month Follow-Up after Implementing a Strategy to Shorten the Time to Surgery
Authors: Merchán-Galvis Angela , Anaya Rafael , Rodriguez Mireia , Llorca Jordi , Castejón Mercé , Gil José María , Millan Angélica , Estepa Verónica , Cardona Elena , Garcia-Sanchez Yaiza , Ruiz Ana , Martinez-Zapata Maria Jose ,   AFFEcT Study Group
Published: February 2023

Background: We evaluated a strategy to shorten the time from admission to surgery in patients with proximal femur fractures on chronic antiplatelet therapy. We reported a 12-month follow-up on complications and quality of life (QoL). Methods: Multicentre, open-label, randomized, parallel clinical trial. Patients were randomized to either early platelet function-guided surgery (experimental group) or delayed surgery (control group). Medical and surgical complications and QoL (EQ-5D-5L questionnaire) were assessed during the hospital stay, and after hospital discharge at 30 days, and 6 and 12 months. Results: From 156 randomized patients, 143 patients underwent surgery. The mean age was 85.5 (7.8) years and 68.0% were female. After hospital discharge, 5.7% of patients had surgical wound complications and 55.9% had medical complications, with 42.7% having serious adverse events. QoL improved significantly after surgery, with the best scores at the six-month follow-up. The overall mortality was 32.2%. There were no differences between early and delayed surgery groups in any assessed outcomes. Conclusion: It seems safe to reduce the time of surgery under neuraxial anaesthesia in patients with hip fractures on chronic antiplatelet therapy by platelet function testing. QoL in particular improves in the first six months after surgery.
Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes
Authors: Mattei Pierre , Gal Jocelyn , Chamorey Emmanuel , Dassonville Olivier , Poissonnet Gilles , Aloi Déborah , Barret Médéric , Safta Inga , Saada Esma , Sudaka Anne , Culié Dorian , Bozec Alexandre
Published: February 2023

Background: The aims of this study were to evaluate the clinical outcomes and their predictive factors in locally advanced hypopharyngeal cancer (HC) patients included in a docetaxel-cisplatin-fluorouracil induction chemotherapy (ICT)-based larynx preservation (LP) program. Methods: Between 2005 and 2021, 82 patients with a locally advanced resectable HC who received ICT in an LP program were included in this retrospective study. The predictors of oncologic and swallowing outcomes were determined in univariate and multivariate analyses. Results: The three- and five-year overall survival (OS) rates were 67 and 54%, respectively. The T4 tumor stage was the only predictive factor of poor response to ICT (p = 0.03). In multivariate analysis, a T stage = 4 (p = 0.02), an ICT cycle number < 3 (p = 0.003) and the absence of a response to ICT (p = 0.03) were significantly associated with worse OS. A low body mass index before therapy (p = 0.003) and enteral nutrition during therapy (p = 0.005) were significantly associated with severity of dysphagia 6 months after treatment. Conclusions: The T stage, number of ICT cycles performed and response to ICT are the main predictors of oncologic outcomes. Patients with T4 HC are poor candidates for LP and should be referred to immediate radical surgery.
The Role of Temporal Order in Egocentric and Allocentric Spatial Representations
Authors: Iachini Tina , Ruotolo Francesco , Rapuano Mariachiara , Sbordone Filomena , Ruggiero Gennaro
Published: February 2023

Several studies have shown that spatial information is encoded using two types of reference systems: egocentric (body-based) and/or allocentric (environment-based). However, most studies have been conducted in static situations, neglecting the fact that when we explore the environment, the objects closest to us are also those we encounter first, while those we encounter later are usually those closest to other environmental objects/elements. In this study, participants were shown with two stimuli on a computer screen, each depicting a different geometric object, placed at different distances from them and an external reference (i.e., a bar). The crucial manipulation was that the stimuli were shown sequentially. After participants had memorized the position of both stimuli, they had to indicate which object appeared closest to them (egocentric judgment) or which object appeared closest to the bar (allocentric judgment). The results showed that egocentric judgements were facilitated when the object closest to them was presented first, whereas allocentric judgements were facilitated when the object closest to the bar was presented second. These results show that temporal order has a different effect on egocentric and allocentric frames of reference, presumably rooted in the embodied way in which individuals dynamically explore the environment.
Classification of Skin Cancer Using Novel Hyperspectral Imaging Engineering via YOLOv5
Authors: Huang Hung-Yi , Hsiao Yu-Ping , Mukundan Arvind , Tsao Yu-Ming , Chang Wen-Yen , Wang Hsiang-Chen
Published: February 2023

Many studies have recently used several deep learning methods for detecting skin cancer. However, hyperspectral imaging (HSI) is a noninvasive optics system that can obtain wavelength information on the location of skin cancer lesions and requires further investigation. Hyperspectral technology can capture hundreds of narrow bands of the electromagnetic spectrum both within and outside the visible wavelength range as well as bands that enhance the distinction of image features. The dataset from the ISIC library was used in this study to detect and classify skin cancer on the basis of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and seborrheic keratosis (SK). The dataset was divided into training and test sets, and you only look once (YOLO) version 5 was applied to train the model. The model performance was judged according to the generated confusion matrix and five indicating parameters, including precision, recall, specificity, accuracy, and the F1-score of the trained model. Two models, namely, hyperspectral narrowband image (HSI-NBI) and RGB classification, were built and then compared in this study to understand the performance of HSI with the RGB model. Experimental results showed that the HSI model can learn the SCC feature better than the original RGB image because the feature is more prominent or the model is not captured in other categories. The recall rate of the RGB and HSI models were 0.722 to 0.794, respectively, thereby indicating an overall increase of 7.5% when using the HSI model.
Allograft and Autologous Reconstruction Techniques for Neglected Achilles Tendon Rupture: A Mid-Long-Term Follow-Up Analysis
Authors: Jiménez-Carrasco Cristina , Ammari-Sánchez-Villanueva Fadi , Prada-Chamorro Estefanía , García-Guirao Antonio Jesús , Tejero Sergio
Published: February 2023

Achilles tendon ruptures that are not immediately recognized and treated are sometimes diagnosed as delayed injuries and may require different surgical repair options based on gap size. The potential complications associated with using an allograft for reconstruction may lead some surgeons to prefer the use of autologous techniques. However, allografts are often considered a salvagement option when large defects are present. In this study, we examined the long-term clinical outcomes and complications of 17 patients who underwent surgical repair for chronic ruptures with large gaps using both autologous and allograft techniques. During an 11-year period, nine patients were treated with autologous techniques (mean gap of 4.33 ± 1.32 cm) and Achilles allograft reconstruction was performed in eight patients (47.1%) (mean gap of 7.75 ± 0.89 cm). At a mean of 82 ± 36.61 months of follow-up, all 17 patients (100%) were able to perform a single heel rise and improved AOFAS (American Orthopaedic Foot and Ankle Society) and ATRS (Achilles Tendon Total Rupture Score) scores. No infections, complications, or re-ruptures were recorded at the end of the follow-up. No significant differences were found in the AOFAS and ATRS scales between both techniques. When an extensive defect is present, the reconstruction with an Achilles tendon allograft can be considered a proper treatment option, as it does not show a higher rate of complications than autologous techniques achieving similar functional outcomes.
Ovarian Pregnancy: 2 Case Reports and a Systematic Review
Authors: Almahloul Zukaa , Amro Bedayah , Nagshabandi Zuhdi , Alkiumi Iman , Hakim Zeinabs , Wattiez Arnaud , Tahlak Muna , Koninckx Philippe R.
Published: February 2023

Ovarian pregnancy is a rare but well-known pathology. However, pathophysiology, diagnosis and treatment are not established. Therefore, all case reports on ovarian pregnancy published in PubMed from November 2011 till November 2022 were reviewed and two case reports were added. In these 84 case reports, 8% of ovarian pregnancies occurred in women without or with blocked oviducts and 23% were localised on the other side than the corpus luteum. Since symptoms are not specific, ovarian pregnancy has to be suspected in all women with abdominal bleeding. Surgical excision is the preferred treatment. However, since an associated intra-uterine pregnancy cannot be excluded, care should be taken not to interrupt this intra-uterine pregnancy with the uterine cannula or by damaging the corpus luteum. In conclusion, in women with abdominal bleeding, an ovarian pregnancy cannot be excluded, even in women with a negative pregnancy test or an empty uterus on transvaginal ultrasonography. Therefore, a laparoscopy is indicated but the surgeon should realise that an associated intra-uterine pregnancy also cannot be excluded and that therefore care should be taken not to interrupt this intra-uterine pregnancy by the uterine cannula or by damaging the corpus luteum.
Epidermolysis Bullosa Acquisita—Current and Emerging Treatments
Authors: Tešanović Perković Deša , Bukvić Mokos Zrinka , Marinović Branka
Published: February 2023

Epidermolysis bullosa acquisita (EBA) is a rare chronic autoimmune subepidermal blistering disease of the skin and mucous membranes, usually beginning in adulthood. EBA is induced by autoantibodies to type VII collagen, a major component of anchoring fibrils in the dermal–epidermal junction (DEJ). The binding of autoantibodies to type-VII collagen subsequently leads to the detachment of the epidermis and the formation of mucocutaneous blisters. EBA has two major clinical subtypes: the mechanobullous and inflammatory variants. The classic mechanobullous variant presentation consists of skin fragility, bullae with minimal clinical or histological inflammation, erosions in acral distribution that heal with scarring, and milia formation. The inflammatory variant is challenging to differentiate from other autoimmune bullous diseases, most commonly bullous pemphigoid (BP) but also mucous membrane pemphigoid (MMP), Brunsting–Perry pemphigoid, and linear IgA dermatosis. Due to its recalcitrance conventional treatment of epidermolysis bullosa acquisita is shown to be demanding. Here we discuss novel therapeutic strategies that have emerged and which could potentially improve the quality of life in patients with EBA.
Choroidal and Retinal Imaging Biomarkers in Different Types of Macular Neovascularization
Authors: Toto Lisa , Ruggeri Maria Ludovica , Evangelista Federica , Trivigno Chiara , D’Aloisio Rossella , De Nicola Chiara , Viggiano Pasquale , Doronzo Emanuele , Di Nicola Marta , Porreca Annamaria , Mastropasqua Rodolfo
Published: February 2023

Background: The aim of this study was to investigate optical coherence tomography (OCT) and OCT angiography (OCTA) parameters in patients with neovascular age-related macular degeneration (nAMD) and macular neovascularization (MNV) type 1, type 2, and type 3. Methods: In this retrospective study, 105 treatment-naïve eyes of 105 patients (60 men and 45 women) with a definite diagnosis of active nAMD and MNV of different types and 105 frequency-matched age and gender healthy subjects were evaluated (61 men and 44 women). All subjects underwent a full ophthalmic examination and multimodal imaging assessment, including spectral domain (SD) OCT and OCTA. The main outcome measures were choroidal vascularity index (CVI), subfoveal choroidal thickness (SFCT), central macular thickness (CMT), and outer retina to choriocapillaris (ORCC) MNV flow area (ORCCFA). Results: Significant differences were found in terms of CVI, CMT, and ORCCFA between MNV 1 and the two other groups. CVI was significantly different between MNV 1 and healthy control patients (p < 0.001) and between MNV 1 and MNV 2 (p < 0.001). ORCCFA and CMT were significantly different between MNV1 and MNV2 (p < 0.005). The difference in subfoveal CT between the three groups was not statistically significant (p = 0.458). A significant negative correlation was found between CVI and ORCCFA. Furthermore, CVI showed a positive correlation with subfoveal CT.
iSTART-II: An Update on the i Support Therapy–Access to Rapid Treatment (iSTART) Approach for Patient-Centered Therapy in Mild-to-Moderate Ulcerative Colitis
Authors: D’Amico Ferdinando , Magro Fernando , Caron Benedicte , Dignass Axel , Jairath Vipul , Hart Ailsa , Kotze Paulo Gustavo , Paridaens Kristine , Awadhi Sameer Al , Kobayashi Taku , Siegmund Britta , Peyrin-Biroulet Laurent , Danese Silvio
Published: February 2023

The i Support Therapy–Access to Rapid Treatment (iSTART) was an initiative to improve patient-centered management in mild-to-moderate ulcerative colitis (UC). Our aim was to update the iSTART recommendations in order to include fecal calprotectin (FC) in the monitoring of patients with UC and improve their management. Twelve physicians from nine countries worldwide attended a virtual international consensus meeting on 4 May 2022. Data from three systematic reviews were analyzed, and a new systematic review investigating all studies reporting measurement of FC at home was conducted. Based on literature evidence, statements were formulated, discussed, and approved by voting. Statements were considered approved if at least 75% of participants agreed with a proposed statement. Fourteen statements were approved. Based on this consensus, FC measurement should be routinely performed for monitoring patients with mild-to-moderate UC to identify disease relapses early and initiate an appropriate treatment. Further studies are needed to assess whether self-monitoring of FC is associated with better disease control and improved patients’ quality of life.
Association between White Matter Hyperintensities Burden and Cognitive Function in Adult Asymptomatic Moyamoya Disease
Authors: Shen Jun , Xu Ziwei , Liu Zhengxin , Duan Yu , Wei Wenshi , Chang Jie
Published: February 2023

Background and Purpose: White matter hyperintensities (WMH) caused by chronic cerebral hypoperfusion are common in Moyamoya disease (MMD) patients, but WMH burden with comprehensive cognition in adult asymptomatic MMD remains unknown. This study tried to investigate the association between the WMH burden and cognitive function in adult asymptomatic MMD. Methods: Sixty-four adult asymptomatic MMD patients without surgical revascularization were enrolled in this study and underwent a 3T MRI scan and complete cognitive tests from 2021 to 2022. WMH volume was extracted with brain anatomical analysis using the diffeomorphic deformation (BAAD) toolbox, which works on SPM 12 software. Multivariable linear regression analysis was performed to assess the association between WMH burden and cognitive function in asymptomatic MMD. Results: Firstly, our data showed that lower education levels and higher WMH burden were strongly related to global cognitive impairment after adjusting for other variables. Secondly, WMH severity was significantly associated with several domains of neurocognitive function, including memory, semantic memory, and executive function. Finally, when stratified by sex, the female participants with WMH severity had lower cognitive performance in all areas than male participants. Conclusions: These results suggest that WMH burden was highly correlated with global cognition, memory, semantic memory, and executive function in asymptomatic MMD. Especially in female participants, the relationship became more evident.
The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD): Changes in Preferred Treatment Strategies and Medications over 20 Years and Five Editions
Authors: Jang Seung-Ho , Bahk Won-Myong , Woo Young Sup , Seo Jeong Seok , Park Young-Min , Kim Won , Jeong Jong-Hyun , Shim Se-Hoon , Lee Jung Goo , Jon Duk-In , Min Kyung Joon
Published: February 2023

Background. The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) is an expert consensus guideline for depressive disorder created in 2002, and since then, four revisions (2006, 2012, 2017, 2021) have been published. In this study, changes in the content of the KMAP-DD survey and recommendations for each period were examined. Methods. The development process of the KMAP-DD was composed of two stages. First, opinions from experts with abundant clinical experience were gathered through surveys. Next, a final guideline was prepared through discussion within the working committee regarding the suitability of the results with reference to recent clinical studies or other guidelines. Results. In mild depressive symptoms, antidepressant (AD) monotherapy was preferred, but when severe depression or when psychotic features were present, a combination of AD and atypical antipsychotics (AD + AAP) was preferred. AD monotherapy was preferred in most clinical subtypes. AD monotherapy was preferred for mild depressive symptoms, and AD + AAP was preferred for severe depression and depression with psychotic features in children, adolescents, and the elderly. Conclusions. This study identified the changes in the KMAP-DD treatment strategies and drug preferences in each period over the past 20 years. This work is expected to aid clinicians in establishing effective treatment strategies.
Association between Type 1 Diabetes Mellitus and Periodontal Diseases
Authors: Costa Rosana , Ríos-Carrasco Blanca , Monteiro Luís , López-Jarana Paula , Carneiro Filipa , Relvas Marta
Published: February 2023

Gingivitis and periodontitis are chronic inflammatory diseases that affect the supporting tissues of the teeth. Although induced by the presence of bacterial biofilms, other factor, such as tobacco smoking, drugs, and various systemic diseases, are known to influence their pathogenesis. Diabetes mellitus and periodontal diseases correspond to inflammatory diseases that have pathogenic mechanisms in common, with the involvement of pro-inflammatory mediators. A bidirectional relationship between type 2 diabetes and periodontitis has been documented in several studies. Significantly less studies have focused on the association between periodontal disease and type 1 diabetes. The aim of the study is to analyze the association between periodontal status and type 1 diabetes mellitus. The “Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines” was used and registered at PROSPERO. The search strategy included electronic databases from 2012 to 2021 and was performed by two independent reviewers. According to our results, we found one article about the risk of periodontal diseases in type 1 diabetes mellitus subjects; four about glycemic control; two about oral hygiene; and eight about pro-inflammatory cytokines. Most of the studies confirm the association between type 1 diabetes mellitus and periodontal diseases. The prevalence and severity of PD was higher in DM1 patients when compared to healthy subjects.
Ticagrelor Resistance in Cardiovascular Disease and Ischemic Stroke
Authors: He Song , Lin Yapeng , Tan Quandan , Mao Fengkai , Chen Kejie , Hao Junli , Le Weidong , Yang Jie
Published: February 2023

Ticagrelor, acting as a reversible platelet aggregation inhibitor of P2Y12 receptors (P2Y12R), is regarded as one of the first-line antiplatelet drugs for acute cardiovascular diseases. Though the probability of ticagrelor resistance is much lower than that of clopidogrel, there have been recent reports of ticagrelor resistance. In this review, we summarized the clinical application of ticagrelor and then presented the criteria and current status of ticagrelor resistance. We further discussed the potential mechanisms for ticagrelor resistance in terms of drug absorption, metabolism, and receptor action. In conclusion, the incidences of ticagrelor resistance fluctuated between 0 and 20%, and possible mechanisms mainly arose from its absorption and receptor action. Specifically, a variety of factors, such as the drug form of ticagrelor, gut microecology, and the expression and function of P-glycoprotein (P-gp) and P2Y12R, have been shown to be associated with ticagrelor resistance. The exact mechanisms of ticagrelor resistance warrant further exploration, which may contribute to the diagnosis and treatment of ticagrelor resistance.
Endovascular Thrombectomy with or without Intravenous Thrombolysis for Anterior Circulation Large Vessel Occlusion in the Imperial College London Thrombectomy Registry
Authors: D’Anna Lucio , Foschi Matteo , Russo Michele , Dolkar Tsering , Vittay Orsolya , Dixon Luke , Bentley Paul , Brown Zoe , Hall Charles , Halse Omid , Jamil Sohaa , Jenkins Harri , Kalladka Dheeraj , Kwan Joseph , Malik Abid , Patel Maneesh , Rane Neil , Roi Dylan , Singh Abhinav , Venter Marius , Lobotesis Kyriakos , Banerjee Soma
Published: February 2023

Background and purpose. Mechanical thrombectomy (MT) is the standard of care for eligible patients with a large vessel occlusion (LVO) acute ischemic stroke. Among patients undergoing MT there has been uncertainty regarding the role of intravenous thrombolysis (IVT) and previous trials have yielded conflicting results regarding clinical outcomes. We aim to investigate clinical, reperfusion outcomes and safety of MT with or without IVT for ischemic stroke due to anterior circulation LVO. Materials and Methods. This observational, prospective, single-centre study included consecutive patients with acute LVO ischemic stroke of the anterior circulation. The primary outcomes were the rate of in-hospital mortality, symptomatic intracranial haemorrhage and functional independence (mRS 0–2 at 90 days). Results. We enrolled a total of 577 consecutive patients: 161 (27.9%) were treated with MT alone while 416 (72.1%) underwent IVT and MT. Patients with MT who were treated with IVT had lower rates of in-hospital mortality (p = 0.037), higher TICI reperfusion grades (p = 0.007), similar rates of symptomatic intracranial haemorrhage (p = 0.317) and a higher percentage of functional independence mRS (0–2) at 90 days (p = 0.022). Bridging IVT with MT compared to MT alone was independently associated with a favorable post-intervention TICI score (>2b) (OR, 1.716; 95% CI, 1.076–2.735, p = 0.023). Conclusions. Our findings suggest that combined treatment with MT and IVT is safe and results in increased reperfusion rates as compared to MT alone.
Intraoperative Low-Dose S-Ketamine Reduces Depressive Symptoms in Patients with Crohn’s Disease Undergoing Bowel Resection: A Randomized Controlled Trial
Authors: Zhang Zhen , Zhang Wen-Hao , Lu Yin-Xiao , Lu Bo-Xuan , Wang Yi-Bo , Cui Li-Ying , Cheng Hao , Yuan Zhen-Yu , Zhang Jie , Gao Da-Peng , Gong Jian-Feng , Ji Qing
Published: February 2023

Background: Patients with Crohn’s disease (CD) undergoing bowel resection often suffer from depression and acute pain, which severely impairs their recovery. We aimed to investigate the effects of S-ketamine preconditioning on postoperative depression in patients with CD undergoing a bowel resection with mild to moderate depression and to observe whether it can relieve postoperative pain and anti-inflammation. Methods: A total of 124 adult patients were randomized into one of the two groups. Patients in the S-ketamine group received a 0.25 mg/kg S-ketamine intravenous drip under general anesthesia induction, followed by a continuous infusion of S-ketamine with 0.12 mg/kg/h for more than 30 min through target-controlled infusion. Patients in the placebo group received 0.9% saline at an identical volume and rate. The primary outcome measure was the 17-item Hamilton depression Scale (HAMD-17). The secondary outcomes were scores on the following questionnaires: a nine-item patient health questionnaire (PHQ-9); a quality of recovery (QoR-15) form; and a numeric rating scale (NRS). Additional secondary outcomes included the levels of C-reactive protein (CRP) and interleukin 6 (IL-6) on postoperative days (PODs) 1, 3, and 5, the length of hospital stay, and opioid use throughout the hospital stay. Results: The scores of PHQ-9 and HAMD-17 in the S-ketamine group were lower than those in the placebo group on postoperative days (PODs) 1, 2, and 7 (p < 0.05). The scores of QoR-15 in the S-ketamine group were higher than those in the placebo group on postoperative days (PODs) 3 and 5 (p < 0.05). The NRS scores of PACU, postoperative days 1 and 2 in the S-ketamine group were lower than those in the placebo group (p < 0.05). There was no significant difference in the CRP and IL-6 levels on postoperative days (PODs) 1, 3, and 5, postoperative complications, and hospital stay between the two groups (p > 0.05). Conclusions: The trial indicated that the intraoperative administration of low-dose S-ketamine could alleviate mild-to-moderate depressive symptoms and postoperative pain in patients with Crohn’s disease undergoing bowel resection without worsening their safety.
An Exploratory Analysis on the 2D:4D Digit Ratio and Its Relationship with Social Responsiveness in Adults with Prader–Willi Syndrome
Authors: Gámez Sara , Cobo Jesus , Fernández-Lafitte Meritxell , Coronas Ramón , Parra Isabel , Oliva Joan Carles , Àlvarez Aida , Esteba-Castillo Susanna , Giménez-Palop Olga , Corripio Raquel , Palao Diego J. , Caixàs Assumpta
Published: February 2023

Prader–Willi syndrome (PWS) is a genetic disorder produced by a lack of expression of paternally derived genes in the 15q11–13 region. Research has generally focused on its genetic and behavioral expression, but only a few studies have examined epigenetic influences. Prenatal testosterone or the maternal testosterone-to-estradiol ratio (MaTtEr) has been suggested to play an important role in the development of the ‘social brain’ during pregnancy. Some studies propose the 2D:4D digit ratio of the hand as an indirect MaTtEr measure. The relationship between social performance and MaTtEr has been studied in other neurodevelopmental conditions such as Autism Spectrum Disorder (ASD), but to our best knowledge, it has never been studied in PWS. Therefore, our study aims to clarify the possible existence of a relationship between social performance—as measured using the Social Responsiveness Scale (SRS)—and MaTtEr levels using the 2D:4D ratio. We found that, as a group, PWS individuals have shorter index and ring fingers than the control group, but no significant difference in the 2D:4D ratios. The 2D:4D ratio showed a correlation only with Restricted Interests and Repetitive Behavior Subscale, where a positive correlation only for male individuals with PWS was found. Considering only PWS with previous GH treatment during childhood/adolescence (PWS-GH), index and ring fingers did not show differences in length with the control group, but the 2D:4D ratio was significantly higher in the right or dominant hand compared to controls.
A Prospective Study of Longitudinal Risks of Cognitive Deficit for People Undergoing Glioblastoma Surgery Using a Tablet Computer Cognition Testing Battery: Towards Personalized Understanding of Risks to Cognitive Function
Authors: Sinha Rohitashwa , Masina Riccardo , Morales Cristina , Burton Katherine , Wan Yizhou , Joannides Alexis , Mair Richard J. , Morris Robert C. , Santarius Thomas , Manly Tom , Price Stephen J.
Published: February 2023

Glioblastoma and the surgery to remove it pose high risks to the cognitive function of patients. Little reliable data exist about these risks, especially postoperatively before radiotherapy. We hypothesized that cognitive deficit risks detected before surgery will be exacerbated by surgery in patients with glioblastoma undergoing maximal treatment regimens. We used longitudinal electronic cognitive testing perioperatively to perform a prospective, longitudinal, observational study of 49 participants with glioblastoma undergoing surgery. Before surgery (A1), the participant risk of deficit in 5/6 cognitive domains was increased compared to normative data. Of these, the risks to Attention (OR = 31.19), Memory (OR = 97.38), and Perception (OR = 213.75) were markedly increased. These risks significantly increased in the early period after surgery (A2) when patients were discharged home or seen in the clinic to discuss histology results. For participants tested at 4–6 weeks after surgery (A3) before starting radiotherapy, there was evidence of risk reduction towards A1. The observed risks of cognitive deficit were independent of patient-specific, tumour-specific, and surgery-specific co-variates. These results reveal a timeframe of natural recovery in the first 4–6 weeks after surgery based on personalized deficit profiles for each participant. Future research in this period could investigate personalized rehabilitation tools to aid the recovery process found.
Vulnerability Analysis of the Cultural Heritage Sites—The Roman Edifice with Mosaic, Constanța, Romania
Authors: Andra-Topârceanu Andreea , Verga Mihaela , Mafteiu Mihaiu Eugen , Andra Marius-Daniel , Marin Marian , Pintilii Radu-Daniel , Mazza Giampietro , Carboni Donatella
Published: February 2023

Heritage monuments are religious, historical, strategic, or civil edifices and could be deteriorated or even damaged due to their exposure to natural and anthropogenic hazards. The Roman Edifice with Mosaic (II-IV A.D.), the largest civil edifice (2040 m2) in Eastern Europe, is an ancient civil edifice built on the steep cliff in the western part of the Black Sea, Constanța, Romania, and is exposed to geomorphological and hydrogeological processes, which are affected by degradation. The main objective of this paper is to assess the current state of this ancient historical site in relation to environmental instability and offer scientific support for the rehabilitation process through interdisciplinary and non-destructive methods. Geophysical methods had been applied to comparatively analyze the spatial variations and flows of groundwater around the Roman Edifice with Mosaic in 2008 and 2019. Geomorphological hazards had already been inventoried and mapped. The results emphasize the state of degradation of the Roman mosaic pavement and ancient walls, mainly through high variations in the deposits’ moisture due to poor maintenance, which caused suffosion, and slip processes, bringing the mosaic into a high vulnerability range. The vulnerability map of the Roman Edifice with Mosaic environment is a necessary tool for continuously improving risk management because it clearly emphasizes the sectors that still have hazards.
Living on the Edge—Mismatches and Expectations in a Changing Landscape
Authors: Morgado Sofia
Published: February 2023

This paper deals with the confrontation between the forms of urbanisation of Lisbon, Portugal, that extends its fringes over the Alcântara Valley. This same Valley—topography and hydrography—plays as determinants of the occupation that will assume distinct narratives. This gradual process is explained through three narratives about (1) the urbanisation of the margin driven by industrialisation and the construction of a stigmatised periphery, (2) the imposition of large capacity infrastructures far beyond what is local, (3) the system of open spaces and landscape projects and the urban brink that the valley claims. The debate focuses on the answers that the urban and landscape project, necessarily going through urban planning and its practical and theoretical scopes, i.e., Urbanism and urban planning thinking, especially in a broad present seeking to discuss both sides of the coin: on the one hand, an urban rehabilitation with public space for all, on the other hand, a qualified and central space that attracts real estate investment that may bring effects contrary to those expected. The article seeks to contribute (1) to a broader perception of the superimposition of processes that transformed the Alcântara Valley, (2) to a fuller dissemination of the urbanistic experiences in the city of Lisbon since this city is still vastly underrepresented in the international (primarily Anglo-Saxon) literature, (3) to deepen the debate between urban rehabilitation, urban regeneration, consequences and opportunities practiced is still trying to cope with.
Natural Resources Conflicts on Borderlands by the Five Spheres of Earth System
Authors: Lee Hansol , Son Jeongeun , Min Suyeon , Lee Haeun , Park Mi Sun
Published: February 2023

Border regions face challenges managing natural resources, which include forests, wildlife, air, and rivers. This study aims to provide an overview of research on various natural resource conflicts and cooperation in borderlands worldwide, considering the five spheres of the Earth system, namely the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The type, scope, and place of natural resource conflicts in the borderlands were examined and key findings for clarifying the conflicts, cooperation, and geographical characteristics were derived using a systematic review methodology. The results indicate that over the last two decades, the conflicts over the hydrosphere are the most dominant. In the following order, conflicts over the biosphere have been frequently dealt with in transboundary areas. In Africa, dams (the anthroposphere) related to the hydrosphere especially influence and cause conflicts as well as cooperation for benefit-sharing among riparian countries. In North America, governance along the transboundary areas has been developed. “In Asia, several neighboring countries are linked through various types of associations ranging from multilateral organizations to sub-national administrations in order to effectively manage the long and wide-ranging natural resources that exist beyond the borders of the countries”. In Europe, numerous protected areas related to the biosphere have been designated. Therefore, this research helps better understand transboundary conflicts based on natural resources and could contribute to designing natural resource management strategies or models in borderlands.
Social Security, Intergenerational Care, and Cultivated Land Renting Out Behavior of Elderly Farmers: Findings from the China Health and Retirement Longitudinal Survey
Authors: Sun Jinghua , Cheng Peng , Liu Zhaoxu
Published: February 2023

In China, the transfer of land management rights has always been a topic of much discussion, as it plays an important role in improving land use efficiency, achieving the optimal allocation of agricultural resources, and protecting farmers’ rights and interests. With the advent of an aging society, elderly farmers are becoming the main force of agricultural production, and their land transfer behavior influences the land transfer situation in China. Based on three-period panel data from the China Health and Retirement Longitudinal Survey (CHARLS), this study uses a binary linear regression model to explore the effects of social security, intergenerational care, and their interactions with elderly farmers’ cultivated land renting out behavior. The results show variability among elderly farmers across different regions of China, as well as a variability in other characteristics that influence cultivated land renting out behavior. It was found that: (1) pension insurance had a significant positive effect on elderly farmers’ cultivated land renting out behavior, while the effect of medical insurance was not significant. Elderly farmers who participated/received pension insurance were 4.3% more likely to choose to rent out farmland, compared to those who did not do so. (2) The frequency of intergenerational care had a significant negative effect on elderly farmers’ cultivated land renting out behavior, while the intensity of intergenerational care had no significant effect. (3) There was an interaction between the frequency of intergenerational care and social security, whereby a high frequency of intergenerational care was found to increase the probability of renting out farmland among elderly farmers with pension insurance.
Citizen Participation and Knowledge Support in Urban Public Energy Transition—A Quadruple Helix Perspective
Authors: Nijkamp Peter , Kourtit Karima , Scholten Henk , Willemsen Esmeralda
Published: February 2023

Climate change, energy transition needs and the current energy crisis have prompted cities to implement far-reaching changes in public energy supply. The present paper seeks to map out the conditions for sustainable energy provision and use, with a particular view to the role of citizens in a quadruple helix context. Citizen participation is often seen as a sine qua non for a successful local or district energy policy in an urban area but needs due scientific and digital support based on evidence-based knowledge (using proper user-oriented techniques such as Q-analysis). The paper sets out to explore the citizen engagement and knowledge base for drastic energy transitions in the city based on the newly developed “diabolo” model, in which in particular digital tools (e.g., dashboards, digital twins) are proposed as useful tools for the interface between citizens and municipal policy. The approach adopted in this paper is empirically illustrated for local energy policy in the city of Rotterdam.
On the Influence of Aging on Classification Performance in the Visual EEG Oddball Paradigm Using Statistical and Temporal Features
Authors: Omejc Nina , Peskar Manca , Miladinović Aleksandar , Kavcic Voyko , Džeroski Sašo , Marusic Uros
Published: February 2023

The utilization of a non-invasive electroencephalogram (EEG) as an input sensor is a common approach in the field of the brain–computer interfaces (BCI). However, the collected EEG data pose many challenges, one of which may be the age-related variability of event-related potentials (ERPs), which are often used as primary EEG BCI signal features. To assess the potential effects of aging, a sample of 27 young and 43 older healthy individuals participated in a visual oddball study, in which they passively viewed frequent stimuli among randomly occurring rare stimuli while being recorded with a 32-channel EEG set. Two types of EEG datasets were created to train the classifiers, one consisting of amplitude and spectral features in time and another with extracted time-independent statistical ERP features. Among the nine classifiers tested, linear classifiers performed best. Furthermore, we show that classification performance differs between dataset types. When temporal features were used, maximum individuals’ performance scores were higher, had lower variance, and were less affected overall by within-class differences such as age. Finally, we found that the effect of aging on classification performance depends on the classifier and its internal feature ranking. Accordingly, performance will differ if the model favors features with large within-class differences. With this in mind, care must be taken in feature extraction and selection to find the correct features and consequently avoid potential age-related performance degradation in practice.
Effect of Storage Temperature on Storage Life and Sensory Attributes of Packaged Mustard Microgreens
Authors: Dayarathna Nayani N. , Gama-Arachchige Nalin S. , Damunupola Jilushi W. , Xiao Zhenlei , Gamage Ashoka , Merah Othmane , Madhujith Terrence
Published: February 2023

Short shelf life limits the commercial value of mustard microgreens. The present study was conducted to evaluate the effects of different storage temperatures on postharvest quality and sensory attributes of mustard microgreens to identify the optimum storage temperature. Mustard microgreens were stored at 5, 10, 15, 20, and 25 °C in 150 µm polyethylene bags. Samples were drawn at 0, 1, 2, 4, 7, 10, and 14 days and tested for changes in total chlorophyll content, tissue electrolyte leakage, weight loss, antioxidant activity, and sensory attributes. Storage temperature significantly (p < 0.05) affected the product quality, shelf life, and sensory quality. When stored at 5 °C, mustard microgreens showed no significant changes in antioxidant activity or tissue electrolyte leakage and minimal change in other parameters and maintained good overall sensory quality for 14 days. Samples stored at 10 and 15 °C retained good overall sensory quality for 4 and 2 days, respectively. When stored at 20 and 25 °C, microgreens deteriorated beyond consumption within one day. A storage temperature of 5 °C in 150 µm polythene bags can preserve high postharvest quality and sensory attributes for 14 days.
Assessment of Ecological and Toxicological State of Soils and Waters in the Neighborhood of Mining Industry Enterprises in the Armenian Highlands
Authors: Galstyan Meruzhan Haykaram , Larionov Maxim Viktorovich , Sayadyan Hovik Yakhsibek , Sargsyan Karine Shahen
Published: February 2023

The article presents the results of the seven-year study on the state of arable lands and wastewaters in the districts of mining enterprises in Armenia. An assessment of the ecological and toxicological state of wastewaters and contaminated areas was carried out. Methods for their purification are proposed aimed at their further use and obtainment of environmentally safe agricultural products. An area of about 0.5 ha, next to the rural community of Syunik in southern Armenia, has been polluted for many years by mining sludges from the nearest mine watertight cofferdam of the Zangezur copper-molybdenum combine. Activities have been carried out to clean up the soil in this area. After plowing, soil improvers (zeolite, bentonite, and manure) were introduced into the soil. On-site treatments, soil tillage, and the introduction of soil improvers into the soil was implemented in late autumn. Soil and plant samples were taken to determine the content of heavy metals (Cu, Zn, Pb, Co, Mo, Ni). In the following spring, the area was planted with potatoes, eggplant, and peas. A rather high yield was obtained. Analysis of plant samples showed that the content of heavy metals does not exceed the permissible level of the international food safety standard. At the same time, soil studies were carried out in the adjacent areas of the Sotk mine, located to the southeast of Lake Sevan. It was revealed that due to the increase in the volume of the mining industry and the amount of rock dumps, the organoleptic and chemical indicators of the waters of the Sotk and Masrik rivers deteriorated. Compared to the previous decade, the amounts of suspended particles per 1 L of water have increased by 210…317.0%, in the waters of Sotk—by 32.1 mg/L, and in the waters of Masrik—by 13.2 mg/L. The same tendency is observed regarding the amounts of nitrates, sulfates, and hydrogen index, which is mainly due to the chemical composition of rocks. They contain a large amount of Ca, K, Na, Mg, etc. This trend is especially noticeable along the rivers, where intensive agriculture, primarily livestock farming is carried out. The material of the work solves a complex of environmental and economic problems. It is aimed at ensuring environmental safety, improving the ecological and resource properties of soils, increasing the productivity of cultural phytocenoses and the sanitary and hygienic quality of food products.
Integrated Decision-Making in the Treatment of Colon-Rectal Cancer: The Case of KRAS-Mutated Tumors
Authors: Cherri Sara , Melocchi Laura , Gandolfi Laura , Rossi Giulio , Zaniboni Alberto
Published: February 2023

In recent years, precision medicine has taken an increasing place in various branches of medical oncology, including colorectal cancer. Among the potentially relevant mutations for this cancer is the KRAS mutation, initially defined as “untargetable”; today, we see the birth of new molecules that target one of the variants of the KRAS mutation, KRAS G12C, having a significant impact on the therapeutic options for other malignancies, such as metastatic lung cancer. This fundamental step forward has stimulated scientific research on other potential targets of KRAS, both indirect and direct, and combination treatments aiming to overcome the mechanisms of resistance to these drugs that decrease in efficacy in colorectal cancer. What was once a negative predictive marker of response to anti-EGFR drugs today has become a potential target for targeted treatments. In turn, the prognostic role of the mutation has become extremely interesting, making it a potentially useful element in therapeutic decision-making, not only regarding oncological treatments but also in a more complex and complete manner within a global vision of the patient, involving other figures on the multidisciplinary team, such as surgeons, radiotherapists, and interventional radiologists.
Regulation of Physiological Barrier Function by the Commensal Microbiota
Authors: McArthur Simon
Published: February 2023

A fundamental characteristic of living organisms is their ability to separate the internal and external environments, a function achieved in large part through the different physiological barrier systems and their component junctional molecules. Barrier integrity is subject to multiple influences, but one that has received comparatively little attention to date is the role of the commensal microbiota. These microbes, which represent approximately 50% of the cells in the human body, are increasingly recognized as powerful physiological modulators in other systems, but their role in regulating barrier function is only beginning to be addressed. Through comparison of the impact commensal microbes have on cell–cell junctions in three exemplar physiological barriers—the gut epithelium, the epidermis and the blood–brain barrier—this review will emphasize the important contribution microbes and microbe-derived mediators play in governing barrier function. By extension, this will highlight the critical homeostatic role of commensal microbes, as well as identifying the puzzles and opportunities arising from our steadily increasing knowledge of this aspect of physiology.