bluuebunny/crossref_metadata_2025 huggingface dataset:
Functionality of Zonal Agroforestry Systems on Agricultural Land of Dry Territories
Authors: Pugacheva Anna Michailovna
Published: December 2023

In this study, agroforestry systems (AFSs) are represented by zonal type using the example of agricultural lands of the administrative districts of the Volgograd region for the first time. The average percentage of forest cover in the territories for these categories of land was 0.9%, with the following distribution by zone: real steppe—1.3%; dry steppe—0.97%; and semidesert—0.6%. Cartographic analysis of the spatial distribution of areas of artificial forest plantations, presented in the form of background cartograms, showed the greatest spatial asymmetry and variability in the forest cover index in the semidesert zone (As = 1.68; Ex = −4.08). This is due to the large variation in indicators by occupied space, namely AFS, agricultural land, and arable land. The calculated area of arable land under AFS protection averaged 35% for the region, with the following distribution by zone: real steppe—47% of the area of the zone; dry steppe—22%; and semidesert—82%. The author’s methodological approach presents the exposed AFS area of arable land as open and closed territories. The open territory of the spring period (March) is land at risk of deflation since it is completely free of plants (black fallows, areas covered by spring crops, and tilled crops). It makes up 67% of the exposed area of AFSs. The annual removal of soil from this area of the region was calculated via mathematical analysis. It amounted to 3.08 × 107 tons. Analysis of the AFS species composition showed the following distribution of species: deciduous species—86%; mixed species—8%; and coniferous—6%. This model can be applied to many arid areas to calculate deflationary losses and the amount of additional AFSs needed.
The Influence of Body Size on Behavioral Thermal Preference in Atlantic Cod (Gadus morhua): Larger Fish Favor Colder Waters
Authors: Schakmann Mathias , Christensen Emil Aputsiaq Flindt , Steffensen John Fleng , Svendsen Morten Bo Søndergaard
Published: December 2023

In the context of global warming and the concurrent decrease in ectothermic fish body size, the mechanisms driving this phenomenon remain a subject of scientific debate. This study, utilizing the Atlantic cod (Gadus morhua) as a model organism, delves into the behavioral size-dependent temperature preference in the context of climate change. A significant negative correlation between temperature preference and fish size was discovered, aligning with in situ habitat temperatures and optimal physiological performance metrics from other studies. This correlation suggests that larger fish exhibit a behavioral preference for colder areas, potentially leading to shifts in distribution toward polar regions or deeper waters in response to local global warming. The findings contribute to predictions of species distribution shifts, emphasizing the critical role of size-dependent temperature preference in shaping fish populations and offering valuable insights for conservation efforts. Additionally, the study uncovers a noteworthy relationship between body size and thermal safety margins in fish behavior, providing a novel avenue for future research into the intricate dynamics of thermal regulation in response to climate change. Overall, this research enhances our understanding of the complex interplay between temperature, fish size, and ecological responses, offering crucial information for informed conservation and management strategies.
Effect of Heat Treatment on the Quality and Soft Rot Resistance of Sweet Potato during Long-Term Storage
Authors: Wu Jifeng , Zhang Jingzhen , Ni Wenrong , Xu Ximing , George Melvin Sidikie , Lu Guoquan
Published: December 2023

Heat treatment is a widely applied technique in the preservation of fruits and vegetables, effectively addressing issues such as disease management, rot prevention, and browning. In this study, we investigated the impact of heat treatment at 35 °C for 24 h on the quality characteristics and disease resistance of two sweet potato varieties, P32/P (Ipomoea batatas (L.) Lam. cv ‘Pushu13’) and Xinxiang (Ipomoea batatas (L.) Lam. cv ‘Xinxiang’). The growth in vitro and reproduction of Rhizopus stolonifer were significantly inhibited at 35 °C. However, it resumed when returned to suitable growth conditions. The heat treatment (at 35 °C for 24 h) was found to mitigate nutrient loss during storage while enhancing the structural characteristics and free radical scavenging capacity of sweet potato. Additionally, it led to increased enzyme activities for APX, PPO, and POD, alongside decreased activities for Cx and PG, thereby enhancing the disease resistance of sweet potato against soft rot. As a result, the heat treatment provided a theoretical basis for the prevention of sweet potato soft rot and had guiding significance for improving the resistance against sweet potato soft rot.
Natural Deep Eutectic Solvents for Solubility and Selective Fractionation of Bioactive Low Molecular Weight Carbohydrates
Authors: Jiménez-Amezcua Ignacio , López Martínez Manuel Ignacio , Ruiz Matute Ana Isabel , Sanz María Luz
Published: December 2023

Natural deep eutectic solvents (NADESs) have been shown to be selective and environmentally friendly solvents for the extraction of bioactive compounds. However, studies on the solubility of low-molecular-weight carbohydrates (LMWCs) in NADESs are scarce. In this work, new solubility data of LMWCs in NADESs are provided and a new approach based on the use of these solvents for the efficient fractionation of bioactive carbohydrates was explored for the first time. Several mono- and disaccharides and three NADESs based on choline chloride (ChCl) and different donors (2-ethylene glycol (EtG), glycerol (Gly) and ethanedioic acid dihydrate (Eth)) were considered. While the degradation of carbohydrates, mainly ketoses, was detected with ChCl:Eth due to its acidic nature, ChCl:EtG and ChCl:Gly were found to be useful alternatives for selectively separating bioactive ketoses and their corresponding aldoses (e.g., lactulose/lactose and tagatose/galactose) present in equimolar binary mixtures. In addition, the usefulness of ChCl:EtG for the selective enrichment of lactulose to be used as food ingredient or nutraceutical was proven (from a 25% in the reaction mixture to a 56% in the purified sample). NADESs could be used for the selective fractionation of value-added carbohydrates from interfering sugars for several applications, including food science, engineering or pharmaceuticals.
Co-Delivery System of Vitamin B12 and Vitamin E Using a Binary W/O/W Emulsion Based on Soybean Isolate Protein–Xanthan Gum/Carrageenan: Emulsification Properties, Rheological Properties, Structure, Stability, and Digestive Characteristics
Authors: Gao Tian , Wu Xixi , Gao Yiting , Teng Fei , Li Yang
Published: December 2023

In this study, the soybean protein isolate (SPI)–xanthan gum (XG) or carrageenan (CA) W/O/W emulsions for the co-delivery of vitamin B12 and vitamin E were prepared. The effects of XG and CA concentrations on the physicochemical properties and digestive characteristics of the emulsions were also investigated. The addition of XG and CA improved the SPI aggregation and increased its electrostatic repulsion so that more SPI was adsorbed at the phase interface. The emulsifying activity index and emulsifying stability index increased to 24.09 (XG 0.4%) and 14.00 (CA 0.5%) and 151.08 (XG 0.4%) and 135.34 (CA 0.5%), respectively. The adsorbed protein content increased to 88.90% (XG 0.4%) and 88.23% (CA 0.5%), respectively. Moreover, the encapsulation efficiencies of vitamin B12 and vitamin E were increased to 86.72% (XG 0.4%) and 86.47 (CA 0.5%) and 86.31% (XG 0.4%) and 85.78% (CA 0.5%), respectively. The bioaccessibility of vitamin B12 and vitamin E increased to 73.53% (XG 0.4%) and 71.32% (CA 0.5%) and 68.86% (XG 0.4%) and 68.74% (CA 0.5%). The best properties of the emulsions were obtained at a 0.4% concentration of XG and 0.5% of CA. This study offers a novel system for delivering bioactive substances, which is favorable for the advancement of food with delivery capability in food processing.
Entrepreneurship Dynamics: Assessing the Role of Macroeconomic Variables on New Business Density in Euro Area
Authors: Vyrostková Lenka , Kádárová Jaroslava
Published: December 2023

This article examines the impact of the macroenvironment on enterprises in euro-area countries over the period 2006–2020. Our study builds on important works and theories in the field of business, including the work of Kar and Özsahin. We employ the Panel Least Squares method to estimate the coefficient of selected variables. We identify political, institutional (government effectiveness index, regulatory quality index, rule of law, market capitalization of company, control of corruption, political stability and absence of violence) and financial (financial development index, gross domestic product, inflation rate, unemployment rate, public debt) determinants that can have an effect on entrepreneurship. The article aims to fill a gap in the existing literature by providing new insights from the Eurozone and updated data that were not included in previous literature reviews and studies. In this way, we contribute to expanding knowledge about the relationship between macroeconomic factors and entrepreneurial activities in this specific geographical area, considering the lack of current analyses. According to our results, there is a positive statistically significant relationship between entrepreneurship and gross domestic product per capita, regulatory quality index, and market capitalization of the company and a negative statistically significant relationship between entrepreneurship and rule of law, and public debt.
Transcriptomic Analysis of Hidradenitis Suppurativa: A Unique Molecular Signature with Broad Immune Activation
Authors: Ben Abdallah Hakim , Bregnhøj Anne , Iversen Lars , Johansen Claus
Published: December 2023

Hidradenitis suppurativa is a chronic inflammatory skin disease with limited treatment options. The poorly understood pathogenesis hinders the development of effective treatments; therefore, a pressing need exists to further elucidate the molecular mechanisms in hidradenitis suppurativa. This study investigated the underlying inflammatory pathways and cell types in hidradenitis suppurativa using transcriptomic approaches with RNA sequencing of lesional and non-lesional skin biopsies from hidradenitis suppurativa, which was jointly analyzed with previously published transcriptomic data from atopic dermatitis and psoriasis patients. The differential expression and pathway enrichment analyses demonstrated the activation of multiple inflammatory processes, including the innate and adaptive immune systems, implicated in the hidradenitis suppurativa pathogenesis. In agreement, hidradenitis suppurativa exhibited a unique and heterogeneous cell type signature involving lymphoid and myeloid cells such as B cells and macrophages. Furthermore, hidradenitis suppurativa displayed increased expression of TH1/2/17 signatures with no predominant TH signatures unlike psoriasis (TH1/17) and atopic dermatitis (TH2). In summary, our study provides molecular insights into the pathomechanisms in hidradenitis suppurativa, revealing a strong and widespread immune activation, which may benefit from treatment strategies offering a broad immunomodulation of various key inflammatory pathways. Our data not only corroborate previously reported findings but also enhance our understanding of the immune dysregulation in hidradenitis suppurativa, uncovering novel and potential therapeutic targets.
Potential Application of Self-Assembled Peptides and Proteins in Breast Cancer and Cervical Cancer
Authors: Zhang Shidong , Chen Meiqi , Geng Zijun , Liu Tianjia , Li Shuangyang , Yu Qixuan , Cao Lingling , Liu Da
Published: December 2023

Ongoing research is gradually broadening the idea of cancer treatment, with attention being focused on nanoparticles to improve the stability, therapeutic efficacy, targeting, and other important metrics of conventional drugs and traditional drug delivery methods. Studies have demonstrated that drug delivery carriers based on biomaterials (e.g., protein nanoparticles and lipids) and inorganic materials (e.g., metal nanoparticles) have potential anticancer effects. Among these carriers, self-assembled proteins and peptides, which are highly biocompatible and easy to standardize and produce, are strong candidates for the preparation of anticancer drugs. Breast cancer (BC) and cervical cancer (CC) are two of the most common and deadly cancers in women. These cancers not only threaten lives globally but also put a heavy burden on the healthcare system. Despite advances in medical care, the incidence of these two cancers, particularly CC, which is almost entirely preventable, continues to rise, and the mortality rate remains steady. Therefore, there is still a need for in-depth research on these two cancers to develop more targeted, efficacious, and safe therapies. This paper reviews the types of self-assembling proteins and peptides (e.g., ferritin, albumin, and virus-like particles) and natural products (e.g., soy and paclitaxel) commonly used in the treatment of BC and CC and describes the types of drugs that can be delivered using self-assembling proteins and peptides as carriers (e.g., siRNAs, DNA, plasmids, and mRNAs). The mechanisms (including self-assembly) by which the natural products act on CC and BC are discussed. The mechanism of action of natural products on CC and BC and the mechanism of action of self-assembled proteins and peptides have many similarities (e.g., NF-KB and Wnt). Thus, natural products using self-assembled proteins and peptides as carriers show potential for the treatment of BC and CC.
Metabolites-Based Network Pharmacology to Preliminarily Verify In Vitro Anti-Inflammatory Effect of Ardisiacrispin B
Authors: Zhou Wen , Yang Guixiang , Wen Yushuang , Xiao Qian , Sun Le , Li Yongjun , Gong Zipeng , Wang Yonglin
Published: December 2023

Ardisiae Crenatae Radix is an ethnic medicinal herb with good anti-inflammatory activity. Ardisiacrispin B is one of the main components in Ardisiae Crenatae Radix extract, with a content of up to 16.27%, and it may be one of the pharmacological components through which Ardisiae Crenatae Radix exerts anti-inflammatory activity. At present, reports on ardisiacrispin B mainly focus on anti-tumor effects, and there have been no reports on anti-inflammatory activities. As a triterpenoid saponin, due to its large molecular weight and complex structure, the composition of substances that function in the body may include other forms after metabolism, in addition to compounds with original structures. Exploring the anti-inflammatory effects on the prototypes and metabolites of the compound may provide a more comprehensive response to the characteristics of ardisiacrispin B’s anti-inflammatory action. In this study, ardisiacrispin B was analyzed for metabolites to explore its metabolic processes in vivo. Subsequently, the anti-inflammatory effects of the prototypes and metabolites were further analyzed through network pharmacology, with the expectation of discovering the signaling metabolic pathways through which they may act. Finally, the anti-inflammatory effects of ardisiacrispin B in vitro and the effects on key signaling pathways at the protein level were explored. The results of this study showed that the isolated compounds were confirmed to be ardisiacrispin B. After the metabolite analysis, a total of 26 metabolites were analyzed, and the metabolism process in rats mainly involves oxidation, dehydration, glucuronide conjugation, and others. Speculation as to the anti-inflammatory molecular mechanisms of the prototypes and metabolites of ardisiacrispin B revealed that it may exert its anti-inflammatory effects mainly by affecting the PI3K-AKT pathway. Further anti-inflammatory mechanisms demonstrated that ardisiacrispin B had a good anti-inflammatory effect on LPS-induced RAW264.7 cells and a strong inhibitory effect on NO, TNF-α, and IL-1β release in cells. Furthermore, it had significant inhibitory effects on the expression of PI3K, P-PI3K, AKT, and P-AKT. This study supplements the gaps in the knowledge on the in vivo metabolic process of ardisiacrispin B and explores its anti-inflammatory mechanism, providing an experimental basis for the development and utilization of pentacyclic triterpenoids.
The Dilemma of Rapid AI Advancements: Striking a Balance between Innovation and Regulation by Pursuing Risk-Aware Value Creation
Authors: Ricciardi Celsi Lorenzo
Published: December 2023

This paper proposes the concept of risk-aware actual value as a pivotal metric for evaluating the viability and desirability of AI projects and services in accordance with the AI Act. The framework establishes a direct correlation between the level of risk associated with a product or service and the resulting actual value generated. The AI Act reflects a concerted effort to harness the potential of AI while mitigating risks. The risk-based approach aligns regulatory measures with the specific attributes and potential hazards of distinct AI applications. As trilogue negotiations continue, the regulatory approach of the EU is evolving, highlighting its commitment to responsible and forward-thinking AI governance. Through a dedicated analysis of the AI Act, it becomes evident that products or services categorized as high-risk carry substantial compliance obligations, consequently diminishing their potential value. This underscores the imperative of exercising caution when engaging in projects with elevated risk profiles. Conversely, products or services characterized by lower risk levels are poised to accrue more substantial benefits from their AI and data potential, highlighting the incentive for a discerning approach to risk assessment. Methodologically, we propose an extension of an integrated AI risk management framework that is already existing in the literature, combining it with existing frameworks for measuring value creation from harnessing AI potential. Additionally, we contribute to the applied field of AI by implementing the proposed risk framework across nine industry-relevant use cases. In summation, this paper furnishes a comprehensive approach to achieving equilibrium between innovation and regulation in the realm of AI projects and services. By employing the risk-aware actual value metric, stakeholders are empowered to make informed decisions that prioritize safety and maximize the potential benefits of AI initiatives. This framework may stand as a reference point in this time when fostering responsible and sustainable AI development within the industry becomes of paramount importance.
Microwave-Mediated Synthesis and Characterization of Ca(OH)2 Nanoparticles Destined for Geraniol Encapsulation
Authors: Tryfon Panagiota , Kamou Nathalie N. , Mourdikoudis Stefanos , Vourlias George , Menkissoglu-Spiroudi Urania , Dendrinou-Samara Catherine
Published: December 2023

Nanotechnology presents promising opportunities for enhancing pest management strategies, particularly in protecting active ingredients to prolong their shelf life and effectiveness. Among different approaches, the combination of inorganic nanoparticles with active ingredients such as the main constituents of natural essential oils in one nanoarchitecture is challenging. In this study, hydrophobic calcium hydroxide nanoparticles coated with oleylamime [Ca(OH)2@OAm NPs] were synthesized using microwave-assisted synthesis. These primary NPs were physicochemically characterized and subsequently utilized to prepare nanocapsules (NCs) either alone (Ca NCs) and/or in combination with geraniol at different ratios of Ca(OH)2@OAm NPs and geraniol, i.e. 1:1 (CaGer1 NCs), 1:2 (CaGer2 NCs), and 1:3 (CaGer3 NCs), respectively. Among the formulations, the CaGer2 NCs demonstrated higher encapsulation efficiency (EE) and loading capacity (LC) of 95% and 20%, correspondingly. They exhibited a hydrodynamic size of 306 nm, a ζ-potential of −35 mV, and a monodisperse distribution. Release kinetics of geraniol from CaGer2 NCs indicated a pH-dependent slow release over 96 h at both 25 °C and 35 °C. In vitro antifungal assay against B. cinerea revealed a concentration-dependent activity, and the EC50 values for Ca(OH)2@OAm NPs, Ca NCs, and CaGer2 NCs were estimated to be 654 µg/mL, 395 µg/mL, and 507 µg/mL, respectively. These results underscore the potential of Ca-based nanoformulations to control plant pathogens, suggesting that while Ca NCs showcase potent antifungal attributes, the different architectures/structures play a critical role in the antifungal effectiveness of the nanoformulations that have to be explored further.
The Correlation between the Gut Microbiota of Endoclita signifer (Lepidoptera, Hepialidae) Larvae and Their Host Preferences
Authors: Lu Jintao , Su Xiaoyan , Yang Zhende , Hu Ping
Published: December 2023

Insects’ gut microbiota plays a crucial role in their host selection, adaptation, and plasticity. This study explored the impact of gut bacteria on the adaptation of host selection under different stresses (diverse feeding preferences and no feeding preferences). The seventh instar E. signifer larvae were artificially transferred from the most-selected host E. grandis × E. urophylla (Es) to more preferred hosts, M. apelta (Ma), as well as the non-preferred host, B. papyrifera (Bp). We then obtained the larval gut of three different feeding preference hosts. The gut bacterial DNA was sequenced and analyzed based on 16S rRNA. There were significant differences in the composition of dominant gut bacteria between Es with Ma and Bp, but without significant differences between Ma and Bp. In the process, Burkholderia and Microbacillus with degrading pesticides had significant changes, and Enterococcus with insect gut probiotics also had significant changes. The presence of enterococcus may be one of the main causes of intestinal microbiota changes before and after host transfer. Notably, when the feeding of E. signifer changes, the complex connections that exist between gut bacteria also change. Additionally, there was a negative correlation between the feeding preferences of E. signifer and the metabolic functions of their gut bacteria. This study provided a theoretical basis for the prediction and use of gut bacteria to interfere with the feeding of E. signifer.
The Potential of Intertwining Gene Diagnostics and Surgery for Mitral Valve Prolapse
Authors: Iske Jasper , Roesel Maximilian J. , Cesarovic Nikola , Pitts Leonard , Steiner Annabel , Knoedler Leonard , Nazari-Shafti Timo Z. , Akansel Serdar , Jacobs Stephan , Falk Volkmar , Kempfert Joerg , Kofler Markus
Published: December 2023

Mitral valve prolapse (MVP) is common among heart valve disease patients, causing severe mitral regurgitation (MR). Although complications such as cardiac arrhythmias and sudden cardiac death are rare, the high prevalence of the condition leads to a significant number of such events. Through next-generation gene sequencing approaches, predisposing genetic components have been shown to play a crucial role in the development of MVP. After the discovery of the X-linked inheritance of filamin A, autosomal inherited genes were identified. In addition, the study of sporadic MVP identified several genes, including DZIP1, TNS1, LMCD1, GLIS1, PTPRJ, FLYWCH, and MMP2. The early screening of these genetic predispositions may help to determine the patient population at risk for severe complications of MVP and impact the timing of reconstructive surgery. Surgical mitral valve repair is an effective treatment option for MVP, resulting in excellent short- and long-term outcomes. Repair rates in excess of 95% and low complication rates have been consistently reported for minimally invasive mitral valve repair performed in high-volume centers. We therefore conceptualize a potential preventive surgical strategy for the treatment of MVP in patients with genetic predisposition, which is currently not considered in guideline recommendations. Further genetic studies on MVP pathology and large prospective clinical trials will be required to support such an approach.
Anterior Referencing versus Posterior Referencing in Primary Total Knee Arthroplasty: A Meta-Analysis of Randomized Controlled Trials
Authors: Familiari Filippo , Mercurio Michele , Napoleone Francesco , Galasso Olimpio , Giuzio Ermes , Simonetta Roberto , Palco Michelangelo , DePhillipo Nicholas N. , Gasparini Giorgio
Published: December 2023

(1) Background: The purpose of this study was to perform a systematic review and meta-analysis of studies comparing clinical and radiographic outcomes between anterior referencing (AR) and posterior referencing (PR) systems in total knee arthroplasty (TKA). (2) Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. PubMed, MEDLINE, Scopus, and Cochrane Central databases were searched in August 2022. Data extracted for quantitative analysis included the Knee Society Score (KSS), the Western Ontario and McMaster University (WOMAC) index, knee ROM, posterior condylar offset (PCO), and the posterior condylar offset ratio (PCOR). The methodological quality of the included studies was assessed using the Modified Newcastle–Ottawa Quality Assessment. Randomized controlled trials were assessed with version 2 of the risk of bias tool (RoB2), recommended by the Cochrane Collaboration. (3) Results: For the meta-analysis, five comparative studies met the eligibility criteria. There were 584 patients in all, 294 of whom had AR TKA and 290 of whom had PR TKA. Three studies with 181 and 179 cases in the AR and PR groups, respectively, had reported preoperative KSS. A statistically significant difference was found favoring the PR group. (p = 0.01). The same cases’ postoperative range of motion was documented, and a statistically significant difference was discovered in favor of the AR group. Postoperative PCO was described in four studies in 243 and 241 cases in the AR and PR TKA groups, respectively, and a statistically significant difference was found with a higher postoperative PCO in the PR group (p = 0.003). Postoperative PCOR was calculated in two studies in the same cases in the AR and PR TKA groups and a statistically significant difference was found with a higher postoperative PCOR in the PR group (p = 0.002). (4) Conclusion: Anterior referencing for TKA may result in improved knee ROM postoperatively, while posterior referencing may produce larger PCO and PCOR on postoperative imaging. However, no significant differences were noted in clinical outcomes between the AR and PR groups at final follow-up.
Electrical Impedance Tomography during Abdominal Laparoscopic Surgery: A Physiological Pilot Study
Authors: Rauseo Michela , Spadaro Savino , Mirabella Lucia , Cotoia Antonella , Laforgia Donato , Gaudino Gennaro , Vinella Francesca , Ferrara Giuseppe , Gattullo Adriana , Tullo Livio , Cinnella Gilda
Published: December 2023

Background: Both general anesthesia and pneumoperitoneum insufflation during abdominal laparoscopic surgery can lead to atelectasis and impairment in oxygenation. Setting an appropriate level of external PEEP could reduce the occurrence of atelectasis and induce an improvement in gas exchange. However, in clinical practice, it is common to use a fixed PEEP level (i.e., 5 cmH2O), irrespective of the dynamic respiratory mechanics. We hypothesized setting a PEEP level guided by EIT in order to obtain an improvement in oxygenation and respiratory system compliance in lung-healthy patients than can benefit a personalized approach. Methods: Twelve consecutive patients scheduled for abdominal laparoscopic surgery were enrolled in this prospective study. The EIT Timpel Enlight 1800 was applied to each patient and a dedicated pneumotachograph and a spirometer flow sensor, integrated with EIT, constantly recorded respiratory mechanics. Gas exchange, respiratory mechanics and hemodynamics were recorded at five time points: T0, baseline; T1, after induction; T2, after pneumoperitoneum insufflation; T3, after a recruitment maneuver; and T4, at the end of surgery after desufflation. Results: A titrated mean PEEP of 8 cmH2O applied after a recruitment maneuver was successfully associated with the “best” compliance (58.4 ± 5.43 mL/cmH2O), with a low percentage of collapse (10%), an acceptable level of hyperdistention (0.02%). Pneumoperitoneum insufflation worsened respiratory system compliance, plateau pressure, and driving pressure, which significantly improved after the application of the recruitment maneuver and appropriate PEEP. PaO2 increased from 78.1 ± 9.49 mmHg at T0 to 188 ± 66.7 mmHg at T4 (p < 0.01). Other respiratory parameters remained stable after abdominal desufflation. Hemodynamic parameters remained unchanged throughout the study. Conclusions: EIT, used as a non-invasive intra-operative monitor, enables the rapid assessment of lung volume and regional ventilation changes in patients undergoing laparoscopic surgery and helps to identify the “optimal” PEEP level in the operating theatre, improving ventilation strategies.
Asymmetric Properties of the Heart Rate Microstructure in Healthy Adults during 48 h ECG Recordings
Authors: Sibrecht Greta , Piskorski Jarosław , Krauze Tomasz , Guzik Przemysław
Published: December 2023

Heart rate asymmetry reflects the different contributions of heart rate (HR) decelerations and accelerations to heart rate variability (HRV). We examined the contribution of monotonic runs of HR accelerations and decelerations to the asymmetric properties of the HR microstructure in the 48 h electrocardiograms (ECGs) of healthy adults (n = 101, 47 males, average age of 39 years) and analysed sex differences in the HR microstructure. The HR microstructure was asymmetric for runs of most lengths, except for sequences of two consecutive decelerations (DR2s) or accelerations (AR2s). Women had a higher prevalence of AR2s than men but fewer runs in the range of 4 to 11 consecutive accelerations (AR4–AR11s) and 5 to 11 consecutive decelerations (DR5–DR11s). The longest runs consisted of 47 consecutive accelerations (AR47s) and 27 consecutive decelerations (DR27s). More DR3s than AR3s and more DR4s than AR4s reveal a crossing of HR microstructure asymmetry. In conclusion, more acceleration than deceleration runs demonstrate that the HR microstructure was asymmetric in the 48 h ECGs. This phenomenon was present in both sexes but was more pronounced in men. For shorter runs of 3 and 4 consecutive heartbeats, there was a crossing of HR microstructure asymmetry, with more deceleration than acceleration runs.
Studies of the Possibility of Improving the Quality of Iron Ores and Processing of Technogenic Composite Iron-Containing Waste of Metallurgical Production
Authors: Yessengaliev Dauren , Mukhametkhan Marzhan , Mukhametkhan Yerlan , Zhabalova Gulnara , Kelamanov Bauyrzhan , Kolesnikova Olga , Shyngysbayev Bakhytzhan , Aikozova Laura , Kaskataeva Kuralay , Kuatbay Yerbol
Published: December 2023

Ferrous metallurgy has been and remains one of the main types of production activities that enables humanity to extract, process and produce basic equipment for all types of activities. The growth of ore production as well as the reduction in world reserves of the raw material base have lead to the search for effective methods of processing and preparation of waste for metallurgical processing. The mining and metallurgical sector of the Republic of Kazakhstan, which has its an integrated mining and metallurgical complex with its own coal, iron ore, and energy base, uses iron ores from several deposits. It also includes ash and sludge storage tanks, which store valuable metallurgical waste, such as converter production sludge, rolling scale, and others, the use of which is hindered by the presence of certain harmful impurities in the composition (a rather high content of non-ferrous metals, especially zinc, a high content of oils, etc.). These valuable technological wastes require additional research that may contribute to their use as a charge or as iron-containing components of the charge. Based on the urgency of the tasks of dephosphorylation of iron ores and utilization of human-made waste (converter sludge and rolling scale), studies were conducted to try to eliminate existing problems. The results of the research work make it possible to obtain metals based on prepared pellets with a significantly low phosphorus content; this will enable the use of an oiled rolling scale and converter sludge for the production of a metalized product for steel smelting. The resulting metalized products make it possible to dispose of scale and converter sludge by 70%, and the degree of iron extraction exceeds existing methods by 1–3.5% (92.1–94% vs. 95.6%).
Flavonols as a Potential Pharmacological Intervention for Alleviating Cognitive Decline in Diabetes: Evidence from Preclinical Studies
Authors: Horvat Anđela , Vlašić Ignacija , Štefulj Jasminka , Oršolić Nada , Jazvinšćak Jembrek Maja
Published: December 2023

Diabetes mellitus is a complex metabolic disease associated with reduced synaptic plasticity, atrophy of the hippocampus, and cognitive decline. Cognitive impairment results from several pathological mechanisms, including increased levels of advanced glycation end products (AGEs) and their receptors, prolonged oxidative stress and impaired activity of endogenous mechanisms of antioxidant defense, neuroinflammation driven by the nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), decreased expression of brain-derived neurotrophic factor (BDNF), and disturbance of signaling pathways involved in neuronal survival and cognitive functioning. There is increasing evidence that dietary interventions can reduce the risk of various diabetic complications. In this context, flavonols, a highly abundant class of flavonoids in the human diet, are appreciated as a potential pharmacological intervention against cognitive decline in diabetes. In preclinical studies, flavonols have shown neuroprotective, antioxidative, anti-inflammatory, and memory-enhancing properties based on their ability to regulate glucose levels, attenuate oxidative stress and inflammation, promote the expression of neurotrophic factors, and regulate signaling pathways. The present review gives an overview of the molecular mechanisms involved in diabetes-induced cognitive dysfunctions and the results of preclinical studies showing that flavonols have the ability to alleviate cognitive impairment. Although the results from animal studies are promising, clinical and epidemiological studies are still needed to advance our knowledge on the potential of flavonols to improve cognitive decline in diabetic patients.
Finite Element Analysis of Subperiosteal Implants in Edentulism—On the Basis of the MaI Implant® by Integra Implants®
Authors: Zielinski Rafal , Sowinski Jerzy , Piechaczek Martyna , Okulski Jakub , Kozakiewicz Marcin
Published: December 2023

The MaI Implants® method offers a modern treatment option for specific patients who lack sufficient bone for traditional screw-based implants. The aim of the article is to use Finite Element Analysis (FEA) to examine the behavior of a subperiosteal implant under actual conditions within the oral cavity and to assess the impact of various mechanical factors on the durability of the MaI Implants®. A strength analysis was conducted using Finite Element Analysis for two models. The first was a single subperiosteal implant, while the second was a model of an arch consisting of two single subperiosteal implants connected by a bar. Based on the obtained results, it can be observed that the increase in load from 100 N to 800 N leads to an increase in displacements throughout the implant. Changing the angle from 90 to 30 degrees resulted in a 576% increase in the average displacement value across all multi-units. Stresses in the multi-units range from 23.7 MPa to 268.5 MPa. The lack of proper stabilization of the implant has the greatest impact on the results of displacements. Such displacements are significant for the later positioning of the implant compared to the initial conditions.
Wire Electrochemical Etching of Superhydrophobic Nickel Surfaces with Enhanced Corrosion Protection
Authors: Wu Binghan , Yan Defeng , Lin Junyi , Song Jinlong
Published: December 2023

Superhydrophobic nickel surfaces have significant advantages in the field of corrosion protection compared with traditional nickel corrosion protection methods which need a toxic chemical corrosion inhibitor. Electrochemical etching, an ideal method for fabricating superhydrophobic nickel surfaces, was also limited by low current density, resulting in low processing efficiency. To overcome this limitation, we proposed a new method to fabricate a superhydrophobic nickel surface using a wire electrochemical etching method. The wire electrochemical etching method accomplished the etching process by sweeping a controlled wire cathode across the surface of the anode nickel plate in an environmentally friendly neutral electrolyte, NaCl. The superhydrophobic nickel sample with a contact angle of 153° and a rolling angle of 10° could be fabricated by wire electrochemical etching and modification. Additionally, the optimal parameters of the wire electrochemical etching and the principle of superhydrophobic surface formation had also been systematically investigated, respectively. Moreover, the superhydrophobic nickel surface had self-cleaning performance, antifouling performance, corrosion protection, and abrasion resistance. Wire electrochemical etching improves the current density of processing, which means that this method improves the processing efficiency for fabricating a superhydrophobic nickel surface. This work is expected to enrich the theory and technology for fabricating superhydrophobic nickel surfaces to improve the corrosion protection of nickel.
Microstructural Evolution and Mechanical Properties of a Ni-Based Alloy with High Boron Content for the Pre-Sintered Preform (PSP) Application
Authors: Gong Xiufang , Wu Yunsheng , Gao Zhenhuan , Sun Youbei , Guan Yingbo , Guan Xianjun , Qin Xuezhi , Hou Jieshan , Zhou Lanzhang
Published: December 2023

The pre-sintered preform (PSP) is an advanced technology for repairing the Ni-based superalloy blade in a turbine. In general, boron is added to the Ni-based superalloys in small quantities (<0.1 wt.%) to increase boundary strength and cohesivity. Despite this, the effect of high B content (>1.0 wt.%) on the microstructure evolution and mechanical properties in Ni-based superalloys for the PSP application is rarely studied. The variety, composition and evolution of the precipitates during solution heat treatment in the alloy with high B content were determined by EBSD, EPMA and SEM. The results indicate that Cr, W and Mo-rich M5B3 type borides precipitate from the matrix and its area fraction reaches up to about 8%. The area fraction of boride decreases with the prolonging of solution time and the increase of temperature higher than 1120 °C. The borides nearly disappear after solution treatment at 1160 °C for 2 h. The redissolution of boride and eutectic results in the formation of B-rich area with low incipient melting (about 1189 °C). It can bond metallurgically with the blade under the melting point of the blade, which decreases the precipitation of harmful phases of the blade after PSP repairing. The microhardness within the grain in the PSP work-blank first decreases (lower than 1160 °C) and then increases (higher than 1185 °C) with the increase of solution heat treatment temperature due to the dissolving and precipitation of borides. The tensile strength of the combination of PSP work-blank and Mar-M247 matrix at room temperature after solution treatment is related to the area fraction of boride, incipient melting and the cohesion between PSP work-blank and Mar-M247 matrix.
The Biocompatibility and Self-Healing Effect of a Biopolymer’s Coating on Zn Alloy for Biomedical Applications
Authors: Cesarz-Andraczke Katarzyna , Tuncay Badegül , Pakieła Wojciech , Brytan Zbigniew , Skonieczna Magdalena , Bidulská Jana , Bidulsky Robert
Published: December 2023

The objective of this study was to formulate dip coatings, incorporating casein, NaOH, and nanocrystalline hydroxyapatite (nanoHAp), with self-healing properties for application on ZnMg3.2 wt.% alloy in the field of biomedical applications. This study hypothesizes that the self-healing mechanism within the layer will impede substrate degradation by progressively filling defects where chlorides from simulated body fluids intervene. Furthermore, it aims to mitigate potential damage effects during the implantation process by the layer’s self-healing capabilities. The research focused on the dip-coating process parameters and chemical composition of baths for producing casein coatings on Zn alloy surfaces. This study investigated the impact of casein and NaOH concentration, along with the immersion time of ZnMg3.2 wt.% samples in the coating bath, on the self-healing capability of the coating under simulated human body fluid conditions (Ringer’s solution, temperature: 37 °C). Effective technology was developed by selecting specific chemical compositions and immersion times in the coating bath, enhancing the self-healing progress against coating damage in Ringer’s solution at 37 °C. The most significant self-healing effect was observed when the ZnMg3.2 wt.% substrate underwent a 1 h immersion in a coating bath containing 2 g of casein, 4 g of NaOH, and 0.1 g of nanoHAp powder. Electrochemical tests were instrumental in determining the optimal casein concentration and immersion time of the Zn alloy in the coating bath.
Rewarded Meta-Pruning: Meta Learning with Rewards for Channel Pruning
Authors: Shibu Athul , Kumar Abhishek , Jung Heechul , Lee Dong-Gyu
Published: December 2023

Convolutional neural networks (CNNs) have gained recognition for their remarkable performance across various tasks. However, the sheer number of parameters and the computational demands pose challenges, particularly on edge devices with limited processing power. In response to these challenges, this paper presents a novel approach aimed at enhancing the efficiency of deep learning models. Our method introduces the concept of accuracy and efficiency coefficients, offering a fine-grained control mechanism to balance the trade-off between network accuracy and computational efficiency. At our core is the Rewarded Meta-Pruning algorithm, guiding neural network training to generate pruned model weight configurations. The selection of this pruned model is based on approximations of the final model’s parameters, and it is precisely controlled through a reward function. This reward function empowers us to tailor the optimization process, leading to more effective fine-tuning and improved model performance. Extensive experiments and evaluations underscore the superiority of our proposed method when compared to state-of-the-art techniques. We conducted rigorous pruning experiments on well-established architectures such as ResNet-50, MobileNetV1, and MobileNetV2. The results not only validate the efficacy of our approach but also highlight its potential to significantly advance the field of model compression and deployment on resource-constrained edge devices.
Estimation in Semi-Varying Coefficient Heteroscedastic Instrumental Variable Models with Missing Responses
Authors: Zhang Weiwei , Luo Jingxuan , Ma Shengyun
Published: December 2023

This paper studies the estimation problem for semi-varying coefficient heteroscedastic instrumental variable models with missing responses. First, we propose the adjusted estimators for unknown parameters and smooth functional coefficients utilizing the ordinary profile least square method and instrumental variable adjustment technique with complete data. Second, we present an adjusted estimator of the stochastic error variance by employing the Nadaraya–Watson kernel estimation technique. Third, we apply the inverse probability-weighted method and instrumental variable adjustment technique to construct the adaptive-weighted adjusted estimators for unknown parameters and smooth functional coefficients. The asymptotic properties of our proposed estimators are established under some regularity conditions. Finally, numerous simulation studies and a real data analysis are conducted to examine the finite sample performance of the proposed estimators.
Queueing-Inventory Systems with Catastrophes under Various Replenishment Policies
Authors: Ozkar Serife , Melikov Agassi , Sztrik Janos
Published: December 2023

We discuss two queueing-inventory systems with catastrophes in the warehouse. Catastrophes occur according to the Poisson process and instantly destroy all items in the inventory. The arrivals of the consumer customers follow a Markovian arrival process and they can be queued in an infinite buffer. The service time of a consumer customer follows a phase-type distribution. The system receives negative customers which have Poisson flows and as soon as a negative customer comes into the system, he causes a consumer customer to leave the system, if any. One of two inventory policies is used in the systems: either (s,S) or (s,Q). If the inventory level is zero when a consumer customer arrives, then this customer is either lost (lost sale) or joins the queue (backorder sale). The system is formulated by a four-dimensional continuous-time Markov chain. Ergodicity condition for both systems is established and steady-state distribution is obtained using the matrix-geometric method. By numerical studies, the influence of the distributions of the arrival process and the service time and the system parameters on performance measures are deeply analyzed. Finally, an optimization study is presented in which the criterion is the minimization of expected total costs and the controlled parameter is warehouse capacity.
Eight-Element Dual-Band Multiple-Input Multiple-Output Mobile Phone Antenna for 5G and Wireless Local Area Network Applications
Authors: He Tao , Huang Jianlin , Lu Jiaping , Shi Xiaojing , Liu Gui
Published: December 2023

This paper proposes an eight-element dual-band multiple-input multiple-output (MIMO) antenna that operates in the fifth generation (5G), n78 (3400–3600 MHz), and WLAN (5275–5850 MHz) bands to accommodate the usage scenarios of 5G mobile phones. The eight antenna elements are printed on two long frames, which significantly reduce the usage of the internal space of the mobile phone. Each antenna element is printed on both surfaces of one frame, which consists of a radiator on the internal surface and a defected ground plane on the outer surface. The radiator is a rectangular ring fed by a 50 Ω microstrip line which is printed on the top surface of the system board. A parasitic unit is printed on the outer surface of each frame, which is composed of an inverted H-shaped and four L-shaped patches. Each parasitic unit is connected to the internal surface of the frames through a via, and then it is connected to a 1.5 mm wide microstrip line on the top surface of the system board, which is connected to the ground plane on the bottom surface of the system board by a via. Four L-shaped slots, four rectangular slots, and four U-shaped slots are etched onto the system board, which provides good isolation between the antenna elements. Two merged rectangular rings are printed on the center of each frame, which improves the isolation further. The return loss is better than 6 dB, and the isolation between the units is better than 15 dB in the required working frequency bands. In addition, the use of a defected ground structure not only makes the antenna element obtain better isolation but also improves the overall working efficiency. The measurement results show that the proposed MIMO antenna structure can be an ideal solution for 5G and WLAN applications.