bluuebunny/crossref_metadata_2025 huggingface dataset:
Analyzing the contribution to pathogenesis by three putative transcriptional regulators of Francisella tularensis using the chicken embryo infection model.
Authors: Shania Davis
Published: June 2023

SHANIA DAVIS, MARIAH CASHBAUGH, ELIO DELATORE & JOSEPH HORZEMPA Dept of Biomedical Sciences, West Liberty University, West Liberty, WV, 26074. Analyzing the contribution to pathogenesis by three putative transcriptional regulators of Francisella tularensis using the chicken embryo infection model.

Francisella tularensis is a highly pathogenic bacterium that can be used as a biological weapon. This bacterium causes tularemia which is also known as Rabbit Fever.  Previously, our laboratory identified three F. tularensis loci predicted to encode transcriptional regulators (FTL_0671, FTL_1199, and FTL_1665) that exhibited transcriptional changes in the presence of human erythrocytes.  We hypothesized that because transcriptional modulations were associated with the presence of host cues, these potential transcriptional regulators may be important for pathogenesis.  Therefore, mutants of these three loci and the isogenic wild-type bacterium (strain LVS) were used to infect chicken embryos.  Healthy chicken embryos were injected with 104, 105, or 106 colony forming units of each strain, and chicken embryoys were candled daily for viability. The chicken embryos were housed in an egg incubator (~37°C with occasional rocking) and were observed over a span of 10 days. Neither FTL_0671 nor FTL_1199 affected the pathogenesis of F. tularensis.   However, chicken embryos infected with the FTL_1665 deletion strain exhibited mortality more rapidly compared to those infected with wild-type bacteria suggesting that this locus may be repressing pathogenesis.  Future studies will evaluate the function of FTL_1665 to determine if the protein encoded by this locus truly mediates transcriptional regulation.
Facial Image Generation with Limited Training Data
Authors: Bevan Ethan , Miller Jason Rafe
Published: June 2023

Deep learning models have a wide number of applications including generating realistic-looking images. These models typically require lots of data, but we wanted to explore how much quality is sacrificed by using smaller amounts of data. We built several models and trained them at different dataset sizes, then we assessed the quality of the generated images with the widely used FID measure. As expected, we measured an inverse correlation of -0.7 between image quality and training set size. However, we observed that the small-training-set results had problems not detectable by this experiment. We therefore present an experimental design for a follow-up study that would further explore the lower limits of training set size. These experiments are important for bringing us closer to understanding how much data is needed to train a successful generative model.
The Efficacy, Toxicity & Pharmacology of Dillapiole: a potential new treatment for Tularemia
Authors: Delatore III Elio , Horzempa Joseph , Clark Zachary , Ayala Megan
Published: June 2023

Francisella tularensis, a highly infectious bacterium, is the causative agent of Tularemia (rabbit fever). Categorized by the Center for Disease Control and Prevention as a Category A bioterrorism agent, Francisella tularensis is of the highest level of concern. Previously, we identified that dillapiole, a compound extracted from fennel, dampens F. tularensis virulence gene expression.  While having no apparent effect on the viability of F. tularensis, treatment with this compound leads to reduced bacterial viability during in vitro infection of THP-1 monocytes and RAW 264.7 macrophages.  In this study, we sought to determine if dillapiole exhibited a therapeutic effect in vivo, and to characterize the toxicity and pharmacology of this compound.  In a murine tularemia model, female mice treated with dillapiole trended toward increased survival compared to those treated with the vehicle.  However, dillapiole- or vehicle-treated male mice showed increased mortality compared to the females, suggesting gender-specific differences in the murine immune response to F. tularensis. Dillapiole was not toxic to HEK-293 cells in vitro, nor was this compound toxic to primary human hepatocytes when tested up to a concentration of 11 mg/ml (50 mM).  Dillapiole was shown to be relatively stable in human, rat, and mouse plasma with a half-life greater than 120 minutes in all cases.  However, this compound showed moderately high binding to plasma proteins (86% in human plasma and 75% in mouse plasma).  In addition, while dillapiole showed moderate clearance by human and rat liver microsomes, mouse liver microsomes exhibited high clearance.  Collectively, these data could explain the minimal efficacy observed in vivo.  Therefore, future investigations should involve the rat infection model to determine the potential efficacy of dillapiole as a novel treatment for tularemia.
Taxonomic Standing and Genetic Surveillance of the Spiny Scale Crayfish (Cambarus jezerinaci) in Southeastern Kentucky
Authors: Gebhardt Cassidy , Loughman Zachary
Published: June 2023

In Southeastern Kentucky a small, cold stream-dwelling crayfish, Cambarus jezerinaci, located in the Kentucky and Cumberland River basin may be a part of a species complex. A previous study done in 2008 on the cytochrome oxidase 1 gene (CO1) of C. jezerinaci and Cambarus parvoculus, a sister species in the region, identified a third genetically distinct lineage most similar to C. jezerinaci currently retained as Group B C. jezerinaci. Group B is as different from the true species as the true species is to C. parvoculus, a total CO1 difference greater than 5%.  Morphological characteristics were also compared between C. jezerinaci and C. parvoculus with only rostral states being significant to species identification. However, in light of new genetic lineages previous research suggested the separation of them before morphological comparisons. In 2022 and 2023 research was conducted on both the genetics and morphological differences of C. jezerinaci within two river basins to better understand the taxonomic standing of this crayfish. Determining the true status of C. jezerinaci within these two river basins is important to the conservation of these animals. Continuing genetic research helps us to grow our understanding of what it means to be a species in the modern age and also allows us to learn about the biodiversity and speciation process itself. Given the rapidly changing climate, it is imperative to catalog the true diversity of our freshwater streams and develop conservation action plans for endemic species such as C. jezerinaci.
Characterization of two predicted lipid metabolism genes (FTL_1569 and FTL_1570) in the intracellular pathogen, Francisella tularensis LVS.
Authors: Rachelle Patterson
Published: June 2023

Many species of bacteria enter a viable but non-culturable (VBNC) state when exposed to stressful conditions. The VBNC state acts as an adaptive strategy that allows for long-term survival of bacteria in unfavorable environments. VBNC bacteria are difficult to detect in the environment due to an inability to grow on nutrient agar. Although the ability to enter the VBNC state may be advantageous for bacteria, it poses a risk to human health. Francisella tularensis, transitions rapidly and spontaneously to the VBNC state, giving it the potential to be an excellent model organism for the study of this phenomenon. Microscopic observations reveal that changes in cell morphology are coincident with the VBNC state. To characterize these morphological changes, fluorescence microscopy imaging using membrane lipid staining has been used in the live vaccine strain of F. tularensis. Microscopy imaging suggested that lipid metabolism may be important for the transition into the VBNC state, and the change in morphology. To investigate further, genetic deletion mutants have been constructed from two predicted lipid metabolism genes, FTL_1569 (phosphoglycolate phosphatase) and FTL_1570 (phospholipase D family protein). Gentamicin protection assays with immune cells and red blood cells have been conducted to investigate the role of these genes in virulence of F. tularensis. Our preliminary results suggest that lipid metabolism may play roles in both persistence and in invasion in F. tularensis. (This work was supported by NIH Grant P20GM103434 to the West Virginia IDeA Network for Biomedical Research Excellence).
Rebranding UMKM Desa Watugolong: Meningkatkan Brand Awareness dari UMKM Keripik Gadung
Authors: Febrianti Devi , Arif Sonhaji , Fitriyah Rachmah Nur , Purwanti Lilik , Sari Vita Nur Indah , Akhyar Zulfan Al
Published: June 2023

The role of UMKM is very significant to the Indonesian economy, both in terms of the number of business units, employment, and contribution to gross domestic product (GDP). To develop a business, SMEs cannot be separated from how to brand products effectively. Watugolong Village was a village that has a low level of brand awareness related to the branding of gadung chips SMEs. This community service aims to increase public brand awareness in the economic field. The method used in this community service is in the form of counseling about the understanding of IP and the importance of HKI for the business world. The community service partner was Watugolong Village in Sidoarjo. The results of Community Service obtained were the understanding and desire of the community service object to manage and register IP in the interests of its business.
Pemberian Makanan Tambahan Modifikasi Berbasis Kearifan Lokal pada Balita Stunting dan Gizi Kurang Bersama Anak PAUD Tunas Pelangi di Balai Desa Bluru Kidul
Authors: W Diajeng Ruli , Azizah Zahrotul , Rohimah Budi , Faizin M. Muqorrobynal , Novita Devi
Published: June 2023

The formula given to children who are malnourished/deficient according to the standards set by the World Health Organization (WHO) is made from oil, sugar, milk, water and flour. In addition, PMT (Supplementary Feeding) can be made by yourself with a composition that contains energy and protein intake and is made from ingredients that are easily available to the public at an affordable cost. This community service aims to increase children's understanding of stunting and malnutrition through PMT (Supplementary Feeding). The method used in this community service is PMT (Providing Additional Food) in the form of green beans and healthy snacks. Community service partners are Tunas Pelangi PAUD children in Bluru Kidul village in Sidoarjo. The result of this community service activity is increasing understanding of stunting and malnutrition through PMT (Supplementary Feeding). Provision of modified PMT (Supplementary Feeding) based on local wisdom can be an alternative program for eradicating stunting and malnutrition in villages.
Studi Pemanfaatan Sampah Organik untuk Perkembangbiakan Maggot di Tempat Pengolahan Sampah Terpadu (TPST) Desa Trosobo
Authors: Abdirahman Roy Zulfan , Aini Nurul , Ghofur Abdul , Wulandari Widya Dini , Lestari Fitri Khofita , Putri Dayinta Tias
Published: June 2023

Garbage is a problem faced by almost all countries in the world. This has always been a hot topic of discussion in developing and developed countries. Big cities in Indonesia produce tens of tons of waste every day. Tens of tons of garbage piled up to make residents around it very disturbed. This community service aims to educate the Trosobo village community on the use of organic waste for maggot breeding in the Integrated Waste Processing Site (TPST). Community service is carried out in stages through qualitative methods. The community service partner is Trosobo village in Sidoarjo. The results of Community Service obtained are an understanding of organic waste for maggot breeding. Through this community service, the local community is more concerned about disposing of household waste according to the type of waste, both organic and inorganic, so that officers at TPST can easily manage waste by the established procedures, namely 3R (Reduce, Reuse, Recycle).
BAĞIMSIZLIK SONRASI AZERBAYCAN’IN EKONOMİK GELİŞİM SEYRİ
Authors: YÜCE Mehmet
Published: June 2023

Güney Kafkasya stratejik konumu dolayısıyla tarih boyunca büyük güçlerin dikkati çekmiş ve bu nedenle de söz konusu devletlerin nüfuz mücadele alanı içinde kalmıştır. Güney Kafkasya coğrafyasının bir parçası olan Azerbaycan hem bölgesinin sahip olduğu jeostrajik açıdan hem de kendi topraklarının konumu açısında büyük bir öneme ve jeostratejik konuma sahiptir. Güney Kafkasya hem coğrafi konumu hem de sahip olduğu doğal kaynaklar itibariyle stratejik bir yapı arz etmektedir. Güney Kafkasya, Asya ile Avrupa birleştiren bir geçit olduğu gibi İslam ve Hristiyan medeniyetinin kesiştiği bir bölge özelliğini de taşımaktadır.

Asya-Avrupa arasında bir köprü oluşturan ve kültürlerin kesiştiği önemli bir kavşak noktası olan Güney Kafkasya verimli tarım arazileri yanında doğal gaz, petrol ve demir cevheri gibi madenler bakımından zengin kaynaklara da sahip bulunmaktadır. Enerji tüketimi, petrol ve doğalgaza bağımlılığı giderek artan dünyada petrolün kullanım alanlarının hızla artması nedeniyle dikkatler Kafkasya’ya çevrilmiştir.

Bu zenginliğin işletilmeye başlanması, Kafkasya’da kısa zamanda akla durgunluk verecek değişikliklere neden olmuş ve bölge bütün dünyada tanınmaya başlamıştır.
Performances afectivas
Authors: Depetris Chauvin Irene
Published: June 2023

Este libro pretende contribuir a la comprensión del modo en que diversas artes y performances latinoamericanas contemporáneas lidian con la inexorabilidad del afecto y sus formas de irrupción. Prácticas enmarcadas tanto dentro de la ficción como del documental, en el activismo o en performances de la memoria problematizan modos de mostración, narración y pensamiento, e instalan la dimensión afectiva como vector esencial para pensar lo político. Esto conlleva complejizar nuestra comprensión sobre los afectos y las emociones, y sobre la forma en que son capaces tanto de convocar al espectador como de movilizar nuevas formas de lo común.Los diversos ensayos analizan la potencia de la sexualidad y de los cuerpos disidentes en el cine —destacando la dimensión afectiva de la puesta en escena—, ponen en evidencia la comunicación entre performance, vivencia y archivo en el documental, piensan el rol activo de los afectos en términos de las aristas sensoriales, texturales y gestuales de diversas obras y prácticas artísticas, y trazan los vínculos entre artivismo y afectos para configurar nuevos modos de estar juntos respecto de comunidades periféricas, memorias de las dictaduras y militancias feministas. En esta compilación, afecto, emoción, sensación y sentimiento traban indisoluble relación para pensar formas de la aparición y actuación como tramado espacio-temporal de conocimiento en donde la noción de “performance afectiva” ofrece la posibilidad de pensar otros lazos epistemológicos entre arte y cuerpo, así como otros entramados entre el contexto en el que las prácticas emergen y la articulación de significados relativos a la experiencia estética y política.
Impacto de la pandemia COVID-19 en la prescripción de fármacos en Atención Primaria
Authors: Rovira Illamola Marina , Sotoca Momblona José Miguel , Sisó Almirall Antoni
Published: June 2023

Objetivo: la pandemia por SARS-CoV-2 ha estresado el sistema sanitario y ha producido cambios en la organización de los centros de salud para atender a los pacientes con COVID-19. Como consecuencia, en la Atención Primaria se ha observado una disminución significativa en el seguimiento, control de los pacientes y en el diagnóstico de enfermedades crónicas. Este estudio tiene por objetivo analizar retrospectivamente el impacto de la pandemia de COVID-19 en los tratamientos farmacológicos en tres centros de salud de Atención Primaria urbanos.

Métodos: se analizaron las prescripciones farmacológicas realizadas por médicos de familia entre 2017 y 2020. Se registró el número total de tratamientos y los inicios de tratamiento para diferentes grupos farmacológicos. Calculamos las tasas de incidencia anuales de los pacientes tratados y se comparó la ratio de incidencia de 2020 con la media de las ratios del período 2017-2019.

Resultados: los grupos farmacológicos con mayor reducción en el porcentaje de pacientes tratados en 2020 en comparación con la media de 2017-2019 fueron los antibióticos (-8,5%), los antinflamatorios no esteroideos (-5,9%) y los antiulcerosos (-2,8%). Se observó una reducción significativa en las tasas de incidencia de 2020 en comparación con la media de 2017-2019 para todos los grupos farmacológicos analizados, excepto para los anticoagulantes orales y los antipsicóticos.

Conclusiones: se ha observado una reducción en el consumo global de los fármacos. Se ha producido una disminución significativa en los inicios de tratamiento para la mayoría de grupos farmacológicos analizados.
Evaluación de las características de la clínica típica del síndrome coronario agudo en mujeres del Área Básica de Salud de Florida Sud, Florida Nord y Pubilla Cases de 2015 a 2019
Authors: Baztán Hornillos Ainhoa , Valls Salmerón Marta , Durán Jiménez Carmen , Besa Castellà Marta , Aguilar Margalejo Anna , Motos Bescós Meritxell
Published: June 2023

Objetivo: se pretende analizar la adecuación de la clínica previa al diagnóstico de síndrome coronario agudo (SCA) en mujeres de tres Áreas de Salud de Barcelona. El objetivo secundario fue determinar si existe retraso terapéutico en las mujeres analizadas.

Métodos: estudio observacional descriptivo transversal sobre mujeres con nuevo diagnóstico de SCA durante 2015-2019 a través de recogida de datos de la historia clínica. Se estimó la adecuación clínica mediante el porcentaje de mujeres que presentaban o no la clínica típica de SCA. Se consideró la presencia de otros síntomas sugestivos y de factores de riesgo cardiovascular. Se tuvieron en cuenta el número acumulado de visitas previas al diagnóstico, el decalaje entre diagnóstico y tratamiento y la actuación en Atención Primaria el mes anterior al diagnóstico.

Resultados: se incluyeron 102 mujeres, con una media de edad de 75 años. El 49% presentaron clínica típica (intervalo de confianza [IC] 95%: 39,32-58,72). Los antecedentes más frecuentes fueron hipertensión y dislipemia. De las pacientes analizadas, 11 (10,8%) presentaron debilidad, y, de ellas, 9 (81,8%) presentaron clínica típica, siendo estadísticamente significativo (IC 95%: 4,76-16,80). En el 66,3% de los casos se administró tratamiento inmediato y en el 22,5% se llevó a cabo cateterismo inmediato.

Conclusiones: la mitad de las pacientes presentaron clínica típica y ninguno de los síntomas atípicos fue más prevalente. Solo la mitad de las mujeres recibieron tratamiento temprano, con una minoría de tratamientos invasivos. Podría ser beneficioso una mejora del registro de los síntomas en las historias clínicas para mejorar los tiempos en la instauración de tratamiento.

Palabras clave: síndrome coronario agudo, diferencias de género, retraso diagnóstico.
Prevalencia de la COVID persistente: seguimiento al año de una cohorte poblacional ambulatoria
Authors: Carrera Morodo María , Pérez Orcero Almudena , Ruiz Moreno Javier , Altemir Vidal Arcadi , Larrañaga Cabrera Andrea , Fernández San Martín M.a Isabel
Published: June 2023

Antecedentes y objetivo: la evolución a largo plazo en pacientes con COVID-19 no es suficientemente conocida. El objetivo es estimar la prevalencia de la COVID persistente (estado post-COVID-19) a los 6 y 12 meses en una cohorte poblacional.

Material y métodos: estudio observacional, ambispectivo, realizado en un centro de Atención Primaria, incluyendo pacientes de 18-65 años con COVID-19 diagnosticado entre julio y diciembre de 2020. Se hicieron entrevistas telefónicas a los 6 y 12 meses, analizando la persistencia de síntomas, estado de salud e inicio de psicofármacos.

Resultados: de 143 pacientes, 116 completaron el seguimiento (edad media: 43,6 años, 59% hombres). El 95,7% tuvieron infección leve, siendo el síntoma más frecuente la fatiga (69,8%). El número de síntomas disminuyó tras 6 (p <0,001) y 12 meses (p <0,001), mejorando la percepción de salud (p <0,001) y disminuyendo el tratamiento con psicofármacos (p = 0,04). Tenían estado post-COVID-19 el 41,4% (intervalo de confianza [IC] 95% 32,8-50,5) y el 8,6% (IC 95% 5,0-17,9) a los 6 y 12 meses, respectivamente.

Conclusiones: casi todos los pacientes recuperaron su estado de salud a los 12 meses, con una prevalencia de estado post-COVID-19 inferior a la descrita.

Palabras clave: COVID-19, SARS-CoV-2, pandemia, COVID persistente, Atención Primaria, estudio de cohorte.
Cómo crear un perfil digital de investigador a través de diferentes plataformas online. Una revisión narrativa
Authors: Ares-Blanco Sara , García-Torrecillas Juan Manuel , Barrio-Cortes Jaime
Published: June 2023

Introducción: el aumento de la producción científica se ha acompañado de plataformas para autores donde pueden compartir el curriculum vitae y los artículos publicados. El objetivo de este artículo es hacer una revisión narrativa en relación con los perfiles digitales, el uso de redes sociales (RRSS) profesionales y gestores bibliográficos de utilidad para la investigación en profesionales de Atención Primaria.

Material y métodos: se realizó una búsqueda en la literatura médica para identificar estudios que informaran sobre temas relacionados con perfil investigador, plataformas online para perfiles digitales y gestores de referencias bibliográficas.

Resultados: se recomienda incluir en un perfil: formación, actividad laboral, membresía a instituciones o sociedades científicas, artículos publicados, índice H, citaciones, proyectos financiados, premios recibidos y revisión de artículos en revistas indexadas. Las plataformas más frecuentes son ResearchGate, ORCID, Scopus y Publons, esta última integrada ya en la Web of Science. Todas ellas permiten compartir filiación, artículos publicados y premios recibidos. Las citaciones recibidas solo están disponibles en Scopus y Publons. El índice H está presente en todas las plataformas menos en ORCID. Los proyectos financiados pueden encontrarse en todas las plataformas menos en Publons. ORCID y Publons recogen las revisiones por pares en artículos indexados. Otras plataformas son: Pubmed y Google Scholar que comparten algunas funcionalidades. Los gestores bibliográficos permiten perfiles personales (Zotero), pero ofrecen menos funciones que otras plataformas, aunque sí la creación de grupos de trabajo (Mendeley y Zotero).

Conclusión: tener un perfil investigador permite visibilizar la producción científica en Atención Primaria y contactar con otros investigadores.

Palabras clave: investigación, Atención Primaria, redes sociales, personal investigador, comunicación digital, internet.
Secondary Targets Are Not So Secondary: Commentary on Michael Marks' Case Study of "Jane"
Authors: Ruork Allison K.
Published: June 2023

Michael Marks (2022) describes the case of "Jane," a client presenting with multiple concerns and targets for treatment, who was treated over six months using Dialectical Behavior Therapy (DBT) at the DBT Clinic at Rutgers University (DBT-RU). Treatment of Jane was consistent with the principles of DBT and represented significant progress in treatment broadly and, more specifically, clear gains in addressing therapy interfering behaviors, increasing willingness to engage in accurate expression and needs assertion in her romantic relationships, and decreasing hopelessness, which subsequently decreased suicidal ideation.  Despite this significant progress Marks reports ongoing struggles with noticing change as it was happening, polarization, and painful and frustrating interpersonal transactions. In this commentary, I propose that many of the transactional (and highly understandable) pitfalls experienced by Marks and Jane may have been addressed by a case conceptualization that more actively integrated the “secondary targets” in DBT, which are anchored in the dialectical dilemmas represented by three continua: Emotion Vulnerability versus Self-Invalidation; Unrelenting Crises versus Inhibited Grieving; and Active-Passivity versus Apparent Competence. Specifically, I suggest that consistent and thorough inclusion of secondary targets in treatment can decrease the potential for polarization and transactions that lead to stagnation and can make therapy more efficient. In addition, I address some of the challenges to such a conceptualization.
Kelly’s Circle of Safety and Healing: An Extended Schema Therapy Narrative and Interpretative Investigation
Authors: Edwards David J.A.
Published: June 2023

This is a narrative case study of the psychotherapy of Kelly (pseudonym) that describes processes that took place within the last 17 sessions of a longer therapy of 67 sessions over a period of 26 months. A phenomenologically grounded and coherent account takes readers on an experiential journey that enables them to live through aspects of the process at least partially. These processes began in session 52 in which Kelly saw an image of a circle of caring people within which a series of child parts of herself were able to find a sense of safety and holding.  Over the course of the sessions, eight different child parts approached and eventually entered the circle, each representing a different dissociated set of early schema patterns, each with its own related emotional distress. Through dialogue work and imagery rescripting, the predicament of each child and her unmet needs were brought into focus. This served as the basis for providing corrective emotional experiences that led to the child parts feeling able to voluntarily step into the circle. The material serves as the basis for theoretical-interpretative investigations with a focus on the phenomenology of memory and transformation in experiential psychotherapy.  This is organized under several themes: (1) complexes, schemas, and internal working models; (2) autobiographical memory and the working self; (3) the “theater of consciousness” and the “theater of the imagination”; (4) understanding the figures that entered Kelly’s healing circle; (5) how far back can we remember?  (6) reparenting, corrective experiences, and imagery rescripting; and (7) coping decisions and demanding and punitive features in coping modes. A brief conclusion aims to contribute to our understanding of the phenomenology of corrective experiences and psychological transformation.
Primena medijacije kod restrukturiranja
Authors:   Martin Luther University, Halle-Wittemberg, Germany, Đurić Đuro M. , Jovanović Vladimir M. ,   University Business Academy Novi Sad – Faculty of Economics and Engeenering Management, Novi Sad, Serbia
Published: June 2023

In order to improve business and overcome dificulties, business entities resort to various measures. They can be carried out within or out of any of the procedures established by law. Serbia’s positive law recognizes mediation as a way of resolving disputes. For business entities, the possibility of financial restructuring agreement assisted by institutional mediation is foreseen. Although the legislation does not explicitly provide for it, it is not excluded that the business entity – the debtor, assisted by an individual mediator, reaches an agreement on restructuring with its creditors. In addition, by signing the Singapore Convention on Mediation, Serbia introduced the possibility of cross-border settlement of commercial disputes through mediation. However, in practice, debtors rarely opt for mediation. In the European Union, new preventive instruments are being introduced to prevent insolvency, out of court or in court proceedings. They are intended for honest but insolvent business entities. The purpose of this paper is to analyze the possibility of using the general mediation framework in the restructuring of business entities according to the existing legislation and to consider the possibility of its formal inclusion in the range of preventive instruments.
Osnovne pretpostavke za uvođenje stečaja preduzetnika u Republici Srbiji
Authors:   University of Kragujevac Faculty of Law, Serbia, Sekulić Aleksandra
Published: June 2023

In Republic of Serbia in preparation is draft of Law on insolvency of entrepreneur. By this legal act in our legislative system would be introduced individual insolvency, where also belongs insolvency of entrepreneur. Aim of this paper is analysis of basic assumptions and elements which would be regulated for the purpose of applicability of this institute in legal practice. We are doing this analysis because insolvency of entrepreneur should be distinguished from insolvency of legal entities. For that purpose, we will study legal rules of Directive of preventive restructuring framework on which Law on insolvency of entrepreneur would be based. Also, we will study comparative law solutions of application of Directive. Basic purpose of this paper would be consideration of basic element for this institute in our legal system such as area of application, discharge of debt, jurisdiction, exemption of execution, limitations of insolvency of entrepreneur.
Elektronska menica kao potencijalno novi institut srpskog prava
Authors:   Commercial Court in Belgrade, Serbia, Pešić Vladimir
Published: June 2023

In this paper the author examines whether the bill of exchange can be an electronic record, instead of a paper document. Today, a lot of communication among merchants goes on electronically. That is the reason why there is a need for digitalization of this security. Although it is not regulated in Serbian applicable law, it is necessary to examine basic questions about it, especially its issuing and using. We looked at the regulation of electronic documents and electronic signature, comparing it with the Serbian Bill of Exchange Act. When we consider our applicable law in area of electronic communication and connect it with purpose of bill of exchange, we conclude that it has the space to improve our regulation of this securities, so it will be very significant to introduce the electronic bill of exchange in our legal system. It will result in faster, easier and simpler commercial transactions.
Opravdanost uvođenja klasa akcija – osvrt na primere u sad i regulativu u republici srbiji
Authors: Đukić Tomislav
Published: June 2023

In this paper author will aim to make an analysis of development dual class stock system in the United States through history, with which he will show how, through time, the one share – one vote rule changed and how the practice of exceptions from this rule established and made new rules which companies adjusted to its business and needs. Through analysis of examples from business of some of the leading multinational companies in the United States and analysis of current regulative of classes of shares in the Republic of Serbia, author will compare positive and negative aspects of existence of diferent classes of shares and the justification for its introduction. This system was very represented in the previous century, and in our country it is only the beginning phase of development and its representment still isn’t that much visible despite the fact that it is regulated by law. In the finishing statements, author sums up can the problems that exist in this type of split of shares overcome for the beneft goals that company wants to accomplish.
Contribuições da educação para o desenvolvimento local: o caso do centro educacional do município de Uruçuca no interior da Bahia
Authors: Da Silva Juliana Oliveira , Dos Santos José Ricardo Rosa
Published: June 2023

A pesquisa teve como proposta, demonstrar a importância do Centro Educacional do Município de Uruçuca (Cemur) para a comunidade local com a sugestão de ideias, trabalhos e alternativas que viabilizassem uma educação libertadora. Consistiu num aprofundamento acerca do tema Educação e Desenvolvimento local, com vistas a uma formação cidadã e mobilizada, por meio de uma abordagem qualitativa. Seguindo o método fenomenológico, buscou-se analisar a percepção dos sujeitos pesquisados acerca da realidade do seu entorno e os reflexos das práticas pedagógicas do Cemur para o desenvolvimento local. Também foram realizadas pesquisas bibliográficas, documentais, eletrônicas e de campo, através da observação, da aplicação de entrevistas semiestruturadas e de questionários abertos. Tomou-se como base teórica autores como Freire (1987), Nidelcoff (1994), Brose (2000) e Santos (2013). Percebeu-se, com este estudo, que a escola além do papel socializar o conhecimento tem um comprometimento social de atuar como mediadora de uma educação para conscientização ética e moral, utilizando-se de diálogos reflexivos com os pais e alunos, contribuindo assim para o desenvolvimento local.
Destinasyon Pazarlama, Destinasyon Çekiciliği ve Turizm Gelişimi Aracı Olarak Hüzün Turizmi: Ankara İli Örneği
Authors: YILMAZ Hilal , EŞİTTİ Bekir
Published: June 2023

Hüzün turizmi kültürel ve tarihi varlıklarımızı ürüne dönüştürmek ve turist çekmek açısından önemli bir turizm türüdür. Destinasyonların yönetilmesinde bu turizm türünün kullanılması turizmin kalkınması açısından fayda sağlamaktadır. Çalışmanın literatür kısmında destinasyon pazarlaması, destinasyon çekiciliği, turizm gelişimi ve hüzün turizmi konuları ele alınmıştır. Bu çalışmanın amacı destinasyon pazarlaması, destinasyon çekiciliği ve turizmin gelişimi bağlamında ziyaretçilerin hüzün turizmine yönelik bakış açılarını belirlemektir. Çalışmada nicel araştırma yöntemlerinden anket tekniği kullanılmıştır. Toplamda 533 veri elde edilmiştir. Bunlardan 83 tane anket geçersiz veya eksik olması nedeniyle çıkarılmış ve 450 adet anket analize tabi tutulmuştur. Bulgular katılımcıların verilerine göre destinasyon pazarlaması, destinasyon çekiciliği, turizm gelişimi ve hüzün turizminin birbiriyle ilişki olduğunu ve birbirlerini etkilediklerini göstermiştir. Ayrıca çıkan sonuca göre katılımcıların çoğunluğu hüzün turizmi kavramını bilmemektedir. Katılımcıların çoğunluğu hüzün turizminin destinasyon pazarlama, destinasyon çekicilik ve turizm gelişimi aracı olarak kullanılabileceğini düşünmektedir.
Kalkınma Ajanslarının Turizmin Gelişmesindeki Rolü: Doğu Anadolu Kalkınma Ajansı (DAKA)-Van Örneği
Authors: ÖZKAN Bahadır İnanç , BOYLU Yasin
Published: June 2023

Bu çalışma, Doğu Anadolu Kalkınma Ajansının (DAKA) Van ilindeki turizm sektörüne katkılarını incelemek amacıyla yapılmaktadır. Nitel araştırma yöntemlerinden olgubilim ve görüşme tekniğinin kullanıldığı bu çalışmada, DAKA’nın turizm ve kırsal kalkınma birimi ile beşerî sermaye ve girişimcilik politikaları birimi ile genel sekreterlik birimi seçilmiş ve bu birimlerde çalışanlarla mülakat yapılmıştır. Araştırma soruları ilgili literatürün taranmasıyla oluşturulmuş ve veriler yarı yapılandırılmış mülakat formuyla elde edilmiştir. Verilerin analizi süresi boyunca, alınan cevaplar ayıklanmış, bu işlemden sonra alınan cevaplardan tema, kategori ve alt kategoriler oluşturarak tablo haline getirilmiştir. Araştırmada elde edilen bulgulara göre, kurumsal faaliyetler, turizm temelli kalkınma, paydaşlar, politika belirleme, yatırım, kültürel miras, turizmde hizmet kalitesi, amaç ve hedefler şeklinde temalar ortaya çıkmıştır. Van ili destinasyona özel eylem planı hazırlandığı, turizm sektörüne yönelik olarak eğitimler verildiği, konaklama birimlerine yönelik kapasite artırma desteği verildiği, inanç turizmi, eko turizm gibi alanlara yönelik hedeflerin belirlendiği, mekân kalitesinin artırılması gerektiği, turizm alanında tüm paydaşlarla iş birliğine gidildiği, kurumda ve birim özelinde yeterli sayıda turizm alanında eğitim almış personelin istihdam edilmediği sonuçlarına ulaşılmıştır.
The Addition of C, Zn-C and Sn-C on Anatase Titanium Dioxide (TiO2) for Dye-Sensitized Solar Cells Application
Authors: Novianti Ressa Muhripah , Nursam Natalita Maulani , - Shobih , Hidayat Jojo , Soepriyanto Syoni
Published: June 2023

DSSC (dye-sensitized solar cell) is a third-generation photovoltaic technology that can convert solar energy into electric current using a photoelectrochemical mechanism. Photoelectrode is one of the significant elements in DSSC, where photoexcited electrons are generated, and serves as an electron transport medium. Anatase titanium dioxide (TiO2) is often used as photoelectrode material because of its excellent photoactivity, high stability, non-toxicity, environmental friendliness, and low price. Many DSSC modifications have been conducted to overcome the efficiency limitations in DSSC, and one of them is carried out by modifying the TiO2 via doping. In this study, TiO2 doped with C and co-doping with Zn (Zn-C) and Sn (Sn-C) were prepared using sol-gel reactions, and they were subsequently applied and tested as photoelectrode in DSSC. The results showed that undoped and doped TiO2 had a porous spherical morphology with inhomogeneous particle sizes. The addition of C, Zn-C and Sn-C dopants has reduced in the crystallite size and the band gap energy of TiO2. The efficiency of DSSC with undoped TiO2 DSSC was 3.83%, while the best performance was obtained from DSSC C-TiO2 with an efficiency of 4.20%. In contrast, the DSSC with Zn-C-TiO2 and Sn-C-TiO2 co-doping produced unexpectedly lower efficiency of 0.71% and 0.85%, respectively.
Rheological studies of high-density fracturing fluid using high-density brine and carboxymethyl hydroxypropyl guar (CMHPG) for high-temperature well condition
Authors: Raja Idris R.F.W. , Rosli N.R. , Mohammadian E. , Hasan N.
Published: June 2023

This work investigated carboxymethyl hydroxypropyl guar (CMHPG) as a potential base polymer for a fracturing fluid used in deep tight gas wells, synonym to high-temperature reservoirs. Fracturing is a common method to improve oil production by creating fractures in potentially productive reservoirs using fracturing fluids. Fracturing fluids are typically composed of water, sand, proppant, and many different additives to alter the capabilities of the fluid.A stable high-density fracturing fluid (HDFF) was developed to cope with scorching good temperatures up to 350F (177C)as well as to reduce the surface treating pressure. The HDFF consists of NaBr heavy brine, CMHPG, clay stabilizers, and zirconium and borate crosslinkers. A linear gel fluid was prepared by combining NaBr brine with CMHPG before adding the additives. The resulting fluid was then tested using a high-pressure, high-temperature (HPHT) rheometer.The results showed that the performance of the HDFF was optimum in an alkaline environment between pH 10 to 12. The efficiency of zirconium and borate crosslinkers were optimum at 0.7 ppm and 1.5 ppt, respectively. Concentrations higher than these values are not only uneconomical but will cause the fluid to be overly crosslinked, consequently reducing efficiency. In actual field operation, this is disastrous when the fluid does not flow to the fracturing column but instead swirls around the drill string as the drill string rotates. On the other hand, a reduction of concentration below the optimum values can cause fluid instability at high temperature reservoirs.The study was limited to using two different kinds of crosslinkers and various concentrations. Future studies can be conducted using other kinds of crosslinkers, as well as an investigation into the effects of varying temperatures, pressures, and pH on the HDFF using CMHPG.It can be concluded that HDFF using CMHPG as the base polymer can be a potential use in formulating fracturing fluids.Information on the rheological behaviour of HDFF using NaBr and CMHPG can provide a reference point for future scientists in developing a new formulation of fracturing fluid.
MULTIMORBIDADE EM PESSOAS IDOSAS RESIDENTES NA ZONA RURAL: UM PROTOCOLO DE REVISÃO DE ESCOPO
Authors: Alexandrino Arthur , De Oliveira Caio Bismarck Silva , Nery Cauan Barbosa , Souza Mariana Silva , Xavier Bárbara Letícia de Queiroz , Nogueira Matheus Figueiredo , Mendes Tamires Carneiro de Oliveira , De Lima Kenio Costa
Published: June 2023

Introdução: Com o aumento da longevidade, a população idosa passou a ser mais acometida por doenças crônicas não transmissíveis, bem como o seu acúmulo em um só indivíduo, também conhecido como multimorbidade, sobretudo, nos idosos que residem na zona rural. Objetivo: elaborar um protocolo de revisão de escopo para mapear a literatura acerca da multimorbidade em pessoas idosas residentes na zona rural. Metodologia: trata-se de um protocolo de revisão de escopo que, com base no manual do Joanna Briggs Institute e no PRISMA-ScR, partiu-se da seguinte questão norteadora: “o que há na literatura acerca da multimorbidade em pessoas idosas residentes na zona rural?”. Serão incluídos artigos, documentos oficiais, dissertações e teses após consulta nos seguintes locais: LILACS, PubMed, Embase, SciELO, Scopus, Web of Science e literatura cinzenta, utilizando o software rayyan para gerenciar os materiais selecionados. Não será determinado limite de idioma ou data. O processo de seleção será descrito na revisão. Resultados: Os resultados apresentarão os principais achados, limitações, impactos possíveis lacunas, e recomendações acerca das evidências científicas sobre multimorbidade no contexto de pessoas idosas que residem em área rural. Considerações finais: O estudo permitirá mapear o que se tem na literatura acerca da temática, uma vez que o protocolo em tela apresenta uma metodologia adequada ao propósito da revisão almejada.
O CONTROLE LEGAL DE SISTEMAS DE MEDIÇÃO DE VAZÃO DE PETRÓLEO, UTILIZADOS NAS MEDIÇÕES FISCAIS DE PRODUÇÃO DE PETRÓLEO, NO BRASIL
Authors: Mattos Nilton de Menezes , De Aguiar Junior Edisio Alves
Published: June 2023

O controle legal de instrumentos de medição é vital para a justa concorrência entre indústria, comércio e serviços nas diversas áreas de atuação, contudo, este controle é ainda mais importante nos casos de sistemas de medição de vazão (SMV) de petróleo, uma vez que estes sistemas são de extrema relevância na captação dos royalties pela União. Este artigo elenca e explica a maneira legal, no Brasil, de se prover o controle metrológico destes importantes sistemas de medição, passando pela atuação do Inmetro (Instituto Nacional de Metrologia, Qualidade e Tecnologia), da ANP (Agência Nacional de Petróleo, Gás Natural e Biocombustíveis) e outros players, pela metrologia e metrologia legal, pelo controle legal de instrumentos de medição no Brasil e pelo regulamento técnico que traz requisitos referentes a SMV. A conformidade destes sistemas com a regulação concernente pode se traduzir em lucro social, com influência direta no erário. Ao final, se estabelece uma relação entre o controle legal de instrumentos de medição e a importância de se executar este controle no escopo dos SMV. Ainda, sugere-se a instituição de comitê permanente para a discussão quanto ao controle legal dos sistemas de medição de petróleo.
Atuação do Enfermeiro frente ao Choque Hipovolêmico associado a Lesões Hepáticas e Esplênicas
Authors: Santos Rafael de Carvalho dos , Corrêa Ana Carolina Alexandre , Grijó Gabriella Santana , Silva Lohana Ribeiro Soares da
Published: June 2023

O manejo do choque hipovolêmico torna-se essencial, tendo em vista ser causa maior de morte evitável, e, na busca em minimizar essas ocorrências, algumas estratégias vêm sendo testadas. Dessa maneira, questionou-se: como atua o enfermeiro frente a lesões hepáticas e esplênicas associadas ao choque hipovolêmico? Tem-se como objetivo geral desse estudo: descrever a atuação do enfermeiro frente choque hipovolêmico por lesões hepáticas e esplênicas. A metodologia escolhida foi a revisão integrativa, baseada em 18 artigos selecionados nos bancos de dados eletrônicos. Foram criadas três categorias temáticas: anatomia e fisiologia hepática e esplênica; sinais e sintomas no choque hipovolêmico; e intervenções emergenciais pelo enfermeiro. Concluiu-se que o diagnóstico do choque hipovolêmico associado a lesão hepática e esplênica é efetuado através de uma avaliação clínica cuidadosa os sinais precoces de perfusão e oxigenação tecidual inadequada. Este é o primeiro passo para o sucesso no tratamento. A abordagem inicial deve ser dinâmica, e simultânea, com medidas diagnósticas e terapêuticas, na busca da correção do déficit da perfusão tecidual e prevenir lesão adicional.
A obesidade como um fator de risco para o desenvolvimento de câncer de mama
Authors: Cervini Ricardo , Konzler Andressa Fatima , Daros Luiza Alves , Thiago Igor Rodrigues de S. , Silva Gislaine Francieli da , Centa Ariana
Published: June 2023

O câncer é um conjunto de doenças malignas que possuem como principal característica o crescimento desordenado de células com capacidade de invadir tecidos e órgãos. A obesidade é um dos diversos fatores que estão envolvidos no aparecimento do câncer. Por meio da obesidade a fisiologia molecular do câncer pode ser influenciada através de fatores epigenéticos, fatores de crescimento, citocinas e matriz extracelular. Genes participam no desenvolvimento do câncer, podendo ser os proto-oncogenes que podem se transformar em oncogenes com mutações, ou os genes supressores de tumor, que regulam o crescimento celular. Como a obesidade possui capacidade de causar danos ao DNA, considera-se como um dos principais fatores de risco para o surgimento e desenvolvimento do câncer de mama. Esse câncer pode ser classificado em diferentes tipos, incluindo carcinoma e seus subtipos moleculares, como HER2 positivo, triplo negativo e luminal A e B. O diagnóstico do câncer de mama é realizado por meio da entrevista e exames clínicos, de imagem e avaliação histopatológica. O tratamento é por meio de quimioterapia, terapia neoadjuvante, cirurgia, terapia hormonal e terapia direcionada, sendo indispensável conhecer as características do tumor para o correto tratamento. Devido a obesidade ser um fator de risco importante para o surgimento e desenvolvimento do câncer de mama, medidas simples como prevenção e controle do peso impactam positivamente na redução do risco da doença.
Obesidade e sua relação com o balanço energético
Authors: Barros Leonardo Soares de Albuquerque , Melato Diego , Silva Gislaine Francieli da , Centa Ariana
Published: June 2023

A obesidade é uma epidemia global que representa um fardo para o sistema de saúde pública e está associada ao aumento de doenças cardiometabólicas. Aproximadamente 1,9 bilhão de adultos estão com sobrepeso e 650 milhões estão com obesidade em todo o mundo, segundo a OMS. No Brasil, cerca de 58% da população está com sobrepeso e 22% está com obesidade, e as projeções para 2030 indicam que 30% da população brasileira estará com obesidade. O desequilíbrio energético é o principal fator que leva ao desenvolvimento da obesidade, onde a ingestão excessiva de calorias em relação ao gasto energético resulta em um balanço energético positivo e, eventualmente, um aumento no peso corporal. No entanto, a obesidade não é apenas uma questão de equilíbrio energético. Vários fatores biológicos, como genética, sono e o sistema de recompensa, influenciam no balanço energético e podem levar ao fenótipo da obesidade. É importante compreender esses fatores para combater a obesidade de forma eficaz, e não culpar exclusivamente a dieta e o sedentarismo, o que pode aumentar o estigma social e o preconceito com indivíduos que estão acima do peso ideal.