bluuebunny/crossref_metadata_2025 huggingface dataset:
Periodontal biotype: anatomic features and association with surrounding tissue
Authors: Kopetskiy I. S. , Pobozhieva L. V. , Shevelyuk Yu. V. , Kopetskaya A. I.
Published: September 2020

The high prevalence of periodontal diseases, up to 90%, is an important issue in medicine. The periodontal biotype is one of the most important parameters that determine the course and prognosis of periodontal diseases. Gingival thickness, keratinized tissue, and bone morphology are the main characteristics of the periodontal biotype. This article presents a review of the literature on the characteristics of periodontal biotypes, their response to treatment, and treatment prognosis. A search of electronic databases (Medline, EMBASE, CyberLeninka, Elibrary, and RINC) was performed for the literature review. The article also presents studies about relationships among periodontal biotype, recession, and malocclusion. The thin biotype is a predictive factor of gingival recession. Recessions are characterized by apical migration of marginal gingiva and defects in root coverage. Gingival recession may result from orthodontic movement of teeth, particularly among patients with the thin gingival biotype. The thin and thick biotypes respond differently to inflammation, restorative and surgical effects, and parafunctional habits. A gingival thickness greater than 2 mm can be categorized as the thick biotype and less than 1,5 mm as the thin biotype. Gingival thickness can affect the results of restorative therapy and root coverage procedures. It is necessary to determine the gingival biotype before initiating treatment. Special care must be taken when planning treatment for cases with a thin biotype.
Surgical treatment of severe posttraumatic foot deformity
Authors: Leonchuk S. S. , Chibirov G. M.
Published: September 2020

The surgical treatment of a 17-year-old patient with posttraumatic complex and rigid foot deformity by the transosseous osteosynthesis method by Ilizarov (original frame) is presented in the article. Previously, the patient incurred a fracture of the left tibia. He was treated by open reduction and internal fixation with a plate in the private clinic. Within four years, an equinovarus adductus foot deformity had developed. During our treatment, the deformity of the foot was eliminated without resection of the bones of this segment. After one year of treatment, the patient was satisfied with the functional condition of the foot, its cosmetic appearance, and the absence of pain in the foot. The American Orthopedic Foot and Ankle Society scale score increased significantly from 30 points preoperatively to 82 postoperatively, whereas the visual analog scale (VAS)-pain scale score decreased from 7 to 1. His ankle motion increased from 10 preoperatively to 29 postoperatively. This case demonstrates the possibilities of the Ilizarov method and our approach in the treatment of severe rigid foot deformities by the Ilizarov technique.
Results of subjective evaluation of the satisfaction of parents of newborns with the attitude of medical staff
Authors: Moiseeva K. E. , Alekseeva A. V. , Berezkina E. N.
Published: September 2020

Background. Under current conditions, when a reduction in the birth rate in the Russian Federation becomes a problem of national security of the state, improving the quality of medical care for newborns becomes an important strategic task facing the healthcare service.
Aim.This study aimed to assess the satisfaction of parents of newborns with the attitude of medical personnel to children in healthcare facilities in St. Petersburg.
Materials and methods. An anonymous survey of 4467 mothers of newborns, who received medical care within the compulsory medical insurance in healthcare facilities in St. Petersburg in 2019, was conducted using a random sampling technique. The samples representativeness was tested by the method of Professor A.M. Merkova, and the error in the study did not exceed 3.5% in obstetric care institutions, 4% in childrens multi-specialty hospitals, and 3% in childrens polyclinics (departments).
Results. In general, 74.1% of mothers were completely satisfied with the attitude of doctors toward newborns in obstetric care organizations, 78.2% of mothers in multi-specialty hospitals, and 70.5% of mothers in childrens polyclinics (departments). The proportion of mothers who were completely satisfied with the attitude of the nursing staff to newborns was 51.7% in obstetric care organizations, 52.4% in multi-specialty hospitals, and 76.0% in childrens polyclinics (departments). When assessing the human and professional qualities of doctors in the obstetric care organizations, the average score was 4.45 0.09, which in childrens multi-specialty hospitals was 4.53 0.10, and that of the doctors of childrens polyclinics (departments) was 4.61 0.08 points. The average score determined by mothers of the human and professional qualities of the nursing staff in obstetric care organizations was 4.22 0.08 that in multi-specialty hospitals was 4.16 0.09, and that of the nursing staff in childrens polyclinics (departments) was 4.63 0.09 points.
Conclusion. The level of satisfaction with the attitude of medical personnel toward newborns was within the target value established by the Territorial program of state guarantees (70%), and the level of satisfaction with the attitude of the nursing staff corresponded to the target value only in childrens polyclinics (departments).
The results of screening for prostate cancer in men aged up to 55 years
Authors: Tarend D. T , Sukonko O. G , Krasny S. A , Semenov Svyataslau A. , Karman A. V
Published: September 2020

In an analysis of 5414 men aged 45-55 years with a PSA level > 4 ng/ml, who underwent 6 point biopsy under ultrasound control, during the first round of screening 21 prostate cancer (PCa) cases were diagnosed, that accounted 0,4% of all examined men. To improve the diagnostic for PCa in the second round of screening it was proposed to decline PSA to 2,5 ng/ml as a threshold, and in case of its excess to perform 12points biopsy. Due to this modification the detection of PCa was increased by 1,85 times. Perhaps, introducing of this method will help to make early detection for PCa more effectively.
Oncology in Uzbekistan: achievements and perspectives
Authors: Navruzov Sarimber N. , Alieva D. A
Published: September 2020

The article describes step by step formation and development of cancer care facilities in the Republic of Uzbekistan. It also presents the current status and perspectives for the development of cancer care for the population in Uzbekistan.
Results of surgical treatment of patients with multiple brain metastases
Authors: Kurilina Liudmila R. , Rekhalov A. F , Pavlov S. S , Kolesnikov V. A , Smirnov P. V
Published: September 2020

Objective: to evaluate the results of surgical treatment ofpatients with multiple brain metastases and to determine prognostic factors. Material and methods. 57 patients with multiple brain metastases were operated, 146 metastatic foci were removed. All metastases were removed in 42 persons; only large clinically significant metastases were removed in 15 patients. Whole brain radiation therapy was applied in 37patients, alone or in combination with chemotherapy, 20 patients after surgery received only corticosteroid and symptomatic therapy. Results. Median survival time of the whole group was 7.3 months; for patients, who received adjuvant whole brain radiation therapy - 11.6 months. Two-year survival was 8.8 %. The number of patients with Karnofsky performance score ≥ 70 increased from 12 persons (21,1%) at admission to the hospital to 38 (66.7 %) at 9-1th day after surgery. Median survival time for patients with complete resection was 9,2 months, with partial resection - 3,7 months. Prognostic factors were Karnofsky performance score and RPA class, estimated before operation, but after the corticosteroid therapy: median survival time for patients with RPA-class I was 19.5 monthsversus 5.6 months for patients with RPA- class II and III. Conclusions. Surgery rapidly improves the condition of patients with multiple brain metastases and saves the time for postoperative adjuvant treatment. Median survival time for patients who received adjuvant whole brain radiation therapy reaches 11.6 months. Favorable prognostic factors for prolonged survival are total resection of all lesions, RPA-class I and adjuvant whole brain radiation therapy.
Canceromatosis modelling of intraperitoneal implantation of solid tumours in mice or human
Authors: Andronova N. V , Smirnova G. B , Borisova Ju. A , Kalish'yan M. S , Treshchalina Elena M.
Published: September 2020

In the work there are described the parameters of a canceromatosis by the intraperitoneal implantation of the solid tumors: Lewis lung carcinoma (LLC) to syngeneic regular males of C57Bl6j mice and human subcutaneous breast cancer (BC) xenografts BC-1 to immunodeficient females of mice Balb/c nude. There was shown aggressive LLC canceromatosis which was realized as the solid tumor nodule (from 30-40 singles to the total) growths on a peritoneum (parietal or visceral) and a mesenteries or of the intestinal lymphoid nodules, development of space-occupying ascites (to 3.0 ml), and death of mice for 12-14 days. This model is characterized as moderately sensitive to paclitaxel (inhibition of tumor growth by 84% and increasing of life span of mice up to 46%). BC-1 canceromatosis was low aggressive with development of the single (solitary) solid tumor nodule on a peritoneum in the place of implantation and reaching within 3 weeks of average volume to 300 mm3 without accumulation of ascites, decreasing of the life span or death of mice. This model is characterized as moderately sensitive to paclitaxel with inhibition of the tumor growth by 85%. The obtained data give the ground to consider that both intraperitoneal solid tumors represent themselves to be sensitive to systemic chemotherapy for the model of canceromatosis differing in various aggressiveness of a course and specific symptomatics of the process. For an aggressive LLC canceromatosis the evidential base of efficiency has to be formed on the basis of inhibition of growth of the peritoneal tumor nodules in peritoneal cavity and accumulation ofperitoneal ascites, and also the increase of the mice life span, for a nonaggressive BC-1 canceromatosis - inhibition of the growth of the peritoneal tumor nodule.
Research of the survey patients about psychosocial aspects of outpatient cancer care in Moscow (Russian Federation)
Authors: Kogoniya L. M , Byakhov M. Yu , Fedotov A. Yu , Orlando M. , Minasyan A. A , Sholokhova Evgeniya A.
Published: September 2020

Objective. The aim of the study is the evaluation ofpsychosocial and medico-social aspects of outpatient cancer care by patients in Russian Federation for the time present. Material and Methods. There was executed a sociological survey of consecutively included oncological patients who received chemotherapy or hormonal therapy at two medical institutions in Russia from May 2009 to May 2011. Results. A total of 350 oncological patients participated in the study. The majority of participants (79.7%) were females, the age of the majority of patients ((79.7%)) varied between 50 and 79 years. The most common primary lesion type was breast cancer (51.1%). 17.3% of patients reported that they felt fear, and this number increased to 37.5% in the aged group of from 40 to 49 years. A substantial number of patients (24.0%) felt uncertainty over outcome of their disease and 5.0% reported a feeling of hopelessness. A part of surveyed patients (21.7%) would like to get an understandable instructions in the form of the booklet as on the organization of everyday living as about their disease. 10.9% of patients noted that they had insufficient information about their disease and 18.8% of cases would like to know more about their diagnosis. Approximately the one-third ofparticipants reported about the improvement of the attitude of their spouses (31.7%) and children (32.0%) after the establishment of the oncological diagnosis. Conclusions. Diagnosis of the oncological disease was frequently associated with feelings of discomfort andfear that it might negatively impact on the quality of life in patients and their families. These feelings and the impact may be reduced by virtue of more effective communication and provision of information concerning the disease. Results of the performed two-center survey indicate to the need for elevation of the efficacy of communication between the patient and physician.
EFFECTS OF CORRECTION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS OPERATED FORGASTRIC CANCER
Authors: Olzhayev S. T , Shoykhet Ya. N. , Lazarev A. F
Published: September 2020

The purpose of the study is the assessment of the effect of the correction of endothelial dysfunction on the indices of the function of vascular endothelium and hemostasis system in gastric cancer patients. There were examined 102 patients with advanced gastric cancer at the II (T1-3N1-2M0) and III (T2-4N2-3M0) clinical stage. The control group included 40 healthy subjects matched by age and gender. We evaluated the relationship degree of endothelial dysfunction and its correction results with the outcomes of the treatment after surgery. Patients were divided into 2 groups - the standard of reference (55) and the additional use of means of vascular endothelial function correction (47 patients). Compared group had no significant difference in general and oncological parameters. Additional treatment included the use of the drug L-arginine at a dose of 1.0 g / day in combination with an ACE inhibitor. Statistical analysis envisaged the determination of the degree of significance of differences between groups of indices on the method of Mann-Whitney. As an boundary indication of the presence of the statistical significance there was accepted p < 0.05. There was revealed the presence of significant differences in the degree of damage (the number of circulating endothelial cells) and violations of the functional state of the vascular endothelium in patients exposed standard (main group) treatment and the use of other methods of correction of endothelial dysfunction. In the study group there was also achieved significant correction of hemostasis.
THE ADVANTAGE OF THE TRANSRADIAL APPROACH FOR PROSTATE ARTERY EMBOLIZATION
Authors: Khayrutdinov E. R , Vorontsov I. M , Zharikov S. B , Arablinskiy A. V , Ignatiev Yu. T , Leonov O. V
Published: September 2020

Treatment of benign prostatic hyperplasia is an important and challenging problem of modern medicine. One of the most modern methods of the treatment of this disease is prostatic artery embolization. This procedure is most often done through transfemoral approach. Transradial vascular access has many advantages over the transfemoral access. Our study presents a comparative analysis of the use of transradial and transfemoral approach in this type of interventions. Transradial access was used in 13 patients, and transfemoral access - in 12 patients. The success of the procedure was 100% in both groups. The total duration of the procedure, the time needed for catheterization of internal iliac and prostatic arteries and the radiation exposure were significantly lower in the transradial approach group. There were no significant differences in the incidence of complications between two groups. The use of the transradial access was associated with a significant reduction of the frequency and severity of the discomfort associated with the procedure. Transradial approach has numerous advantages over the transfemoral approach and may have great clinical significance.
TARGETED THERAPY IN COMPREHENSIVE MANAGEMENT OF METASTATIC COLON CANCER
Authors: Feoktistova Polina S. , Karaseva V. V , Khaylenko V. A , Sinelnikova O. A , Zharkova O. V
Published: September 2020

In recent years there has been strong progress in the treatment of metastatic colorectal cancer (mCRC) patients. The gain of the median of the overall survival (mOS) rate was more than doubled due to the introduction in the clinical practice of new compounds, the work of a multidisciplinary team, the timely registration of the disease progress, prescription of combined chemotherapy in the second line. The article presents the immediate and long-term results of a comparative study carried out on the basis of Oncology Centers, 122 mCRC patients were included, most of these patients - 87(71,3%) had surgery firstly, after that all patients were treated with standard chemotherapy FOLFOX-4 in the first-line treatment and FOLFIRI in the second line treatment, two groups of patients in the first and second lines of treatment received a combination of chemotherapy and targeted agents (bevacizumab, cetuximab), depending on the biological properties of the tumor (RAS-gene mutation status). The following results: metastatic progression-free survival (mPFS) for FOLFOX-4 group accounted for 12.0(±1.2) months; FOLFOX-4 + Bevacizumab - 20.3(±1.2) months, FOLFOX-4 + cetuximab - 22.0(± 2.0) months; mPFS for second-line therapy for FOLFIRI + bevacizumab group amounted to 24.0(± 3.1) months, FOLFIRI + cetuximab 22.5(±2.5) months, FOLFIRI-1 8.0(±2.4) months, FOLFIRI-2 6.4(±2.6) months; mOS for FOLFOX-4 group was 49.5(±2.5) months; FOLFOX-4 + Bevacizumab - 45.8(±2.1) months; FOLFOX-4 + cetuximab - 37.4(± 2.0) months; mOS for second-line therapy for FOLFIRI + bevacizumab group was 37.8(± 2.1) months, FOLFIRI + cetuximab - 31.5(± 2.3) months, FOLFIRI-1 - 26.3(± 1.8) months, FOLFIRI-2 - 26.2(± 1.9) months. The adverse events during the treatment of patients are reported.
QUALITY OF LIFE IN THE ELDERLY PATIENTS AFTER SURGERY FOR GASTRIC CANCER
Authors: Nered Sergey N. , Stilidi I. S , Rokhoev G. A
Published: September 2020

The problem of the quality of life of elderly gastric cancer patients after surgical treatment, is still insufficiently studied. Functional results of the management of 91 patients, underwent surgical treatment at the age of 75 years and older, are represented. 35 patients underwent gastrectomy, 56 patients - subtotal distal resection. The quality of life was assessed at the second year after surgery according to both the Performance Scales for the Karnofsky & ECOG Scores, as well as the modified form of EORTC QLQ-STO 22. Only 40% of patients were fully recovered after total gastrectomy and 57.1% of cases - after gastric resection. 28.6% and 35.7% of patients respectively were incapable for full activity and required support. Patients with severe disability and cases needed a significant care amounted to 28.6% and 2.8% in the group of patients after gastrectomy and only 3.6% in the group of cases after the gastric resection. Thus, in elderly patients with gastric cancer after surgical treatment, a significant deterioration of the quality of life is observed, and therefore the tactic of minimization of the radical surgical intervention in this age group is reasonable.
MORBIDITY RATE OF MALIGNANT NEOPLASMAS AND ANALYSIS OF THE ECOLOGICAL STATE OF THE TERRITORY OF THE REPUBLIC OF BURYATIA
Authors: Chimitdorzhieva T. N , Lyakhova N. P , Chimitdorzhieva Galina D.
Published: September 2020

The authors analyzed the incidence rate of malignant neoplasms in the population of the Republic of Buryatia without division into separate locations by regions over a long period, beginning from 1995 to 2015 in comparison with that in the Russian Federation, using a comparative-geographical method. According to statistical data, the growth of general oncopathology has been revealed every year, in connection with which the aim of the work was to search for its causes in the analysis of environmental factors in the region. There was established a high morbidity rate in the population during analyzed four periods: over 1995-2000; 2001-2005; 2006-2010; 2011-2015 in the same regions of the republic, as Bountov, Tarbagataysky, Kabansky, Pribaikalsky, Zaigraevsky, North Baikal, Barguzin and Ulan-Ude. The authors explain this pattern by the abnormal natural conditions of the region, the development of the mining industry, in particular the development of powerful reserves of uranium and polymetallic ores. And the city of Ulan-Ude, where the entire industrial hub and fuel and energy complex is concentrated, is one of the ten most polluted cities in Russia due to the location in a closed basin of a mountainous country. In the first three analysis periods until 2011 there was a low incidence in the high-altitude region of Okinsk, and in Tunkinsky until 2006, in Muisky until 2001, however, in their territories in the last five years, sharp gain was seen respectively from 147%, 205% in relation to 231% initial period. This is probably due to the fact that the development of natural raw materials, begun in the 1960s by the Soviet authorities, is still a handicraft way, leaving a pathological “trace” on the health of the population, manifested in tens of years. The gradual gain of oncopathology is observed in Dzhidinsk, Kizhinginsky, Mukhorshibirsky, Selenginsky, Khorin, Kyakhta districts. However, there are territories of the regions of the republic, like Eravnensky and Ivolginsky, where the incidence is insignificant.
STAGES OF THE DEVELOPMENT OF OVARIAN CANCER SURGERY: LITERATURE REVIEW
Authors: Kozhevnikova Olga V. , Nikogosyan S. O , Kuznetsov V. V , Ananyev V. S
Published: September 2020

The review article considers the course of the development, improvement, and introduction of combined operations in ovarian cancer into the surgical practice of oncogynecologists, analyzes the results of the activity of major oncological centers, as well as the positive and negative aspects of the “aggressive” surgery in ovarian cancer.
CASE OF TREATMENT OF A PATIENT WITH AN AGGRESSIVE FORM OF METASTATIC MELANOMA OF THE SKIN
Authors: Yargunin Sergei A. , Lazarev A. F , Sharov S. V
Published: September 2020

Metastatic melanoma of the skin today remains a difficult task. A revolution in treatment was the emergence of new classes of drugs: inhibitors of regulatory molecules of the key stages of the immune response and tyrokinase receptors, which in mono-mode showed an advantage compared to standard treatment regimens, and their combination is objectively better result compared to mono-mode. Genetic profiling was indispensable for choosing personalized treatment approaches. In the absence of treatment standards for patients with advanced MK, local doctors rely on individual clinical cases, trying to classify them into similar clinical scenarios, which differ in each case. Some authors recommend that these scenarios be included in clinical trials, either as inclusion criteria or stratification factors. Thus, this approach may be a way of personalizing the treatment of patients with MMC. Materials and methods. A 29-year-old patient with MK back surgery was operated on with subsequent adjuvant immunotherapy. When the disease progressed, the patient was prescribed sequentially immuno-, chemo- and combination therapy with anti-CTL4 + PD-1 inhibitors, sanitary excision of soft tissue metastases, a combination of BRAF + MEK inhibitors, polychemotherapy. Results. The personalized therapy of the patient with MMC has led to an increase in the overall duration and quality of life. Conclusion. Despite the consistent application of the majority of the known available treatment regimens to the patient, stabilization of the condition was only possible for a short time. To achieve a complete or partial response to any of the types of treatment failed. But this case can be considered a variant of personalized therapy, which allowed to slow down the development of the disease, keep the patient in good health and a long time, an active lifestyle, improve its quality, which is already a great achievement. The life expectancy without progression in this patient was 9 months, the total life expectancy from the start of treatment was 44 months.
PERSPECTIVES OF INVESTIGATION OF ONCOLOGICAL ASPECTS OF INFECTION CAUSED WITH HEPATITIS C VIRUS
Authors: Mamedov Murad Kiyas oglu , Mamedova T. N , Akhmedov Yu. A.
Published: September 2020

The paper is dedicated to several problems of study of infection caused with hepatitis C virus directly connected with modern theoretical and clinical oncology and professionally interesting from point of view of oncologists, hematologists and specialists in field of medical radiology. The author summarizes data which demonstrated the real existence of at the least main five oncological aspects of the infection. They present material reflected important significance some of these aspects for physician working in oncological units and researchers working in other fields of medicine. First oncological aspect of the infection is based on direct connection of these infection chronic forms with development of hepatocellular cancer of liver. It is interesting that hepatitis C virus today is not considered as a carcinogenic virus and its participation in hepatocarcinogenesis connected with some special mechanisms. Second oncological aspect of the infection is demonstrated with widely spreading this infection among oncological and especially among oncohematological patients staying in profile departments. Existence of this aspect has mainly epidemiologic significance and connected with prevention this infection in oncological units. Third oncological aspect of the infection is that spreading of HCV-infection at oncological patients has important clinical significance. This connected with ability of infection negatively influence to course and prognosis some type of cancer. Besides the infection can play a role of factor limiting possibilities of treatment of cancer patients. Fourth oncological aspect of this infection is that participation of this infection chronic form in some type of non-Hodgkin lymphomas development. Mechanisms of connection this infection with named lymphomas development is not identified. Finally, fifth oncological aspect of the infection consists the modern data demonstrated the statistic connection between the infection and in development of some widely spread non-hepatic malignant tumor. These data have important significance for modern oncology. The authors suggest that further systematic investigation of above mentioned aspects of above mentioned infection may positive influence to development of medical science in general.
Comparative analysis of the receptor status of the primary focus and synchronous axillary metastases in breast cancer patients
Authors: Krumin’ Yu. S. , Khailenko V. A. , Kozlov N. A. , Cheremis G. Yu. , Khailenko D. V. , Artamonova E. V. , Kovalenko E. I. , Kovalenko I. P. , Bokhyan V. Yu.
Published: September 2020

The aim of the investigation. To study concordance of surrogate molecular subtype in the pairs of primary and synchronous axillary metastases in patients with invasive breast cancer (IBC).
Materials and methods. Retrospective analysis included 80 patients aged 28 to 90 years (average age 40.35.3 years) with a first-time diagnosed IBC who underwent surgical treatment at the N.N. Blokhin National Medical Research Center of Oncology during 20162018 years. None of the patients received any neoadjuvant drug therapy. The pathological evaluation of the estrogen receptors (ER), progesterone receptor (PR), HER2 expression and estimation of proliferative activity (Ki-67 index) with subsequent assignment to surrogate subtypes were performed according to ASCO/CAP protocols and the recommendations of the 20132019 San-Gallen Conference on treatment of Early Breast Cancer.
Results. Preliminary results of our study revealed therapeutically significant changes in hormone receptor status, HER2-status and proliferative activity in 12.5% of cases of Luminal A type IBC, 20% of Luminal B/HER2-positive and 4% of Luminal B/Her2-negative subtypes of IBC.
Diagnostic errors in patients with diseases of the chest cavity and ways to reduce them
Authors: Lukyanenko N. Ya. , Shoikhet Ya. N. , Lazarev A. F. , Lubennikov V. A. , Vikhlyanov I. V.
Published: September 2020

This paper presents an algorithm for reducing the risk of errors in the diagnosis of diseases of the chest cavity within 14 days after treatment of patients. The developed algorithm, based on multivariate analysis of the integrated assessment of clinical and radiological descriptors (signs) of diseases, determination of the probability coefficient of errors, software for comparing individual integral data with established typical characteristics for differentiable pathological processes, improved diagnostics, aimed the doctor at an adequate examination, and reduced the risk of error by 20.1%.
Angioplasty of iliac vessels and the part of abdominal aorta in the female patient with non-organ retroperitoneal liposarcoma
Authors: Stilidi I. S , Nikulin Maksim P. , Abgaryan M. G , Kalinin O. E , Anurova O. A
Published: September 2020

The involvement of large vessels in the tumor process is the cause of the refusal of the surgery. Resection of aorta, even in specialized cancer centers is carried out very rarely. We report the result of long-term treatment of the female patient with retroperitoneal liposarcoma with invasion of the iliac artery, and 22 months later - in aorta.
Assessment of efficiency of providing disabled people of the Sverdlovsk region with technical means of rehabilitation and prosthetic and orthopedic products on the basis of the carried-out questioning of disabled people
Authors: Kuznetsova Irina I. , Parpura I. B , Smushkina N. E , Kozhevnikova N. K
Published: September 2020

On the basis of the performed selective questioning of disabled people the assessment of the efficiency of providing disabled people with technical means of rehabilitation is given. The vast majority of technical means of rehabilitation (99,1%) is recommended by experts of medico-social expertise within the Federal list of rehabilitation actions, technical means of rehabilitation and the services provided to the disabled person, accepted by the Government of the Russian Federation approved by the order of December 30, 2005 No. 2347-r. Disabled people received the majority of technical means of rehabilitation through Social insurance fund. Other sources of receiving of technical means of rehabilitation are (in the order ofdecreasing ofpopularity): independent acquisition, rental centers, receiving as a gift. In the Sverdlovsk region there is a need ofthe delivery of the regional list of technical means of rehabilitation consisting of the mostdemanded technical means of rehabilitation not included in the Federal list.
Experience of optimization of adaptive activity of mentally ill patients in conditions of medical rehabilitation department of the district psychoneurologic dispensary
Authors: Milyutin Sergey M. , Karasayeva L. A , Spikina A. A , Valiakhmetova D. T
Published: September 2020

The article analyzes the progress and results of activity of medical-rehabilitation Department, created by reorganization of Department of medical-labor rehabilitation, in the situation of upgrading of the system of rehabilitation strategies. On the basis of categories of the International classification of functioning (ICF) updated the factors of the increase and established an analysis of the dynamics of adaptive activity of the mentally ill patients in the process of implementation of rehabilitation measures, with an emphasis on modified forms of interpersonal interaction. There were illustrated: a method of rehabilitative community led by the Council ofpatients, and involvement in the rehabilitation system of interpersonal interaction not only ofpsychiatrists, psychotherapists, psychologists, but nurses and other medical staff. Results of medical rehabilitation are shown to be optimized due to the emergence of new conditions and prerequisites for the increase in adaptive activity of patients in the rehabilitation center as part of their adaptation to everyday available, «micro-social» environment.
Innovative approach to the rehabilitation of patients undergone surgical treatment of herniated invertebrate discs
Authors: Kulikov A. G , Voronina Daria D. , Luppova I. V , Abramovich S. G
Published: September 2020

One of the most remarkable manifestations of the spinal degeneration is the occurrence of herniation of the invertebrate disc and in more than in 80% of cases the disease is revealed in the lumbar spine. The surgical treatment is merely a phase in the treatment of a patient. The changes persisting in the postsurgical period necessitate the implementation of an early comprehensive rehabilitation program, including along with medication treatment, kinesitherapy, aquatic therapy and physical therapy. The aim of the study - the elevation of the efficacy of rehabilitation ofpatients after surgical treatment of herniated invertebrate discs in lumbar sacral spine by including into the complex of treatment procedures general magnetic therapy. There was performed an examination and observation of 52 patients divided into 2 groups matchedfor the gender, age and main clinical manifestations. All patients received basic therapy including medications, kinesitherapy, hydro kinesitherapy. Patients from the basic group additionally received the course of the general magnetic therapy. It has been found that procedures of the general magnetic therapy were revealed to favourably affect on the common symptoms of the disease, regeneration processes, as well as improves of the state local blood circulation in the area of surgical intervention.
Scoliosis in children: new approaches to the solution of important medical and social problems
Authors: Kulikov A. G , Zaytseva Tatiana N. , Pyzhevskaya O. P , Ivanova E. R
Published: September 2020

Scoliosis, the most prevalent orthopaedic condition affecting children and adolescents, may have long-lasting medical and social consequences. The objective of the present study was to elucidate the possibilities and practicability of the application of a low-frequency electrostatic field for the conservative treatment of grade I and II scoliosis in children. The electrostatic field is shown to promote the development of vibrations of varying strength in biological tissues and their penetration rather deeply into their interior. We examined and treated 94 children divided into two groups matchedfor the age and major clinical manifestation of the disease. All the patients received basic therapy. Patients from the study group were additionally given low-frequency electrostatic therapy. The application of a low-frequency electrostatic field for the conservative treatment of grade I and II scoliosis in the children was shown both to significantly increase its effectiveness and facilitate regression of scoliosis.
Requirements of stroke patients in medical and social rehabilitation and modern technologies of its implementation (according to foreign literature)
Authors: Syrnikova Bela A. , Storozhenko D. V , Temirov Kh. V , Matsokin I. S , Stepanov D. Yu
Published: September 2020

There is presented the analysis of the incidence rate and outcomes of different types of strokes. Depending on the level of average income per capita, these indices have significant differences, which should determine the strategy of medical care, prevention and rehabilitation. The basic element contributing to the restoration of brain structure and functional capabilities of the brain after lesions of the different character, is the phenomenon of neuroplasticity. Neuroplasticity varies widely depending on the location of the lesion and the time elapsed since the end of the impact of the damaging factor. In addition to traditional methods of rehabilitation, more and more attention of scientists is attracted to new technologies associated with both the development of the technical devices used for recovery of cognitive and motor functions, as well as with the improvement of the organization of the rehabilitation process. Out of technological innovations in the review there are presented games controlled by the movement (gesture), including the Nintendo Wii and Xbox Kinect, brain-computer interfaces, wearable robotic gait control system. The organization of the management of rehabilitation process by the patient can play a major role in the enhancement of the motivation in patients. Just the combination of the mobilization of intact functions, and the patient’s motivation with the use of high clinically tested technologies can ensure the success of rehabilitation.
INTESTINAL MICROBIOCENOSIS AND CYTOKINE STATUS IN LUNG CANCER PATIENTS RECEIVING CHEMOTHERAPY
Authors: Serkova Margarita Yu. , Avalueva E. B , Bakulin I. G , Sitkin S. I
Published: September 2020

In patients with oncological diseases chemotherapy leads to the damage of a mucous membrane of gastrointestinal tract, as well as to a deterioration of the intestinal microbiocenosis. The article presents the changes in intestinal microbiocenosis in lung cancer patients, chemotherapy, the nature of the influence appointed in the schemes of the treatment of lung cancer, impact of anticancer drugs on the state of the intestinal microflora, and the improvement of technologies of treatment of lung cancer patients receiving chemotherapy on the basis of supplementation of the complex therapy by the probiotics Material and methods. 41 lung cancer patient receiving the first line of the first cycle of chemotherapy was included. The age of patients varied from 49 to 73 years, the average duration of the disease was 1 year. Patients from the main group (n = 21) received probiotics treatment together with the chemotherapy course. Patients from the control group (n = 20) received only chemotherapeutic preparations. All patients were observed before and after treatment, the study of metabolites of intestinal microorganisms in blood was performed by the method of the gas-liquid chromatography - mass-spectrometry by G.A. Osipov’s method, determination of cytokine status multiplex method. The efficiency of probiotic therapy was evaluated by results of the dynamics of studied indices. Results. The deterioration in intestinal microflora was manifested as the decreased quantity of Lactobacillus, Bifidobacterium, and increased quantity of different pathogenic microorganisms. It was noted decreased rate in the improvement of composition intestinal microflora after the treatment course with the metabiotic. Conclusion. Using of metabiotic medicines with the chemotherapy in lung cancer patients is promising to prevent deterioration of the gut microflora.
THE MODEL OF THE EFFECTIVE QUALITY MANAGEMENT OF COMPLEX REHABILITATION SERVICES FOR INDIVIDUALS WITH DISABILITIES IN NON-STATIONARY FORMS IN A MULTIFUNCTIONAL INSTITUTION FOR DISABLED INDIVIDUALS (OCCUPATIONAL ADAPTATION). PROJECT “PLAN-DO-CHECK-ACT”
Authors: Syrnikova B. A , Semenova Tatiana N. , Kobzar I. Z , Achkasov E. E , Pogosyan G. E
Published: September 2020

The article discloses the experience of the institution of social services in creating a complex rehabilitation model in the combination of three types of services: rehabilitation therapy, social and labor adaptation, occupational adaptation. The article reviews such matters as Human Resources Management, organization of the interaction with disabled people and monitoring their satisfaction through the creation of a Quality Management System in accordance with international standards ISO 9001.
EXPERT VALUE OF VERTEBROGENIC FACTORS IN DISCIRCULATORY ENCEPHALOPATHY PATIENTS (ACCORDING RESULTS OF THE FACTORIAL ANALYSIS)
Authors: Starovoytova Irina M. , Potekhin N. P , Sarkisov K. A , Shumeyko T. V
Published: September 2020

287 patients with the verified diagnosis “discirculatory encephalopathy” (DE) are analyzed. The military-medical commissions have examined 139 people (1st group of comparison), Bureau of medico-social examination - 148 people (the 2nd group of comparison). Middle age in the first group of comparison was - 47.1±7.6 years, in the second one - 56.67±5.11 years. The factorial analysis of the signs characterizing results of laboratory and tool examinations taped the most significant symptom-complexes determining an internal picture of the illness. The greatest contribution to the formation of an internal picture of the illness is made by disturbances of a cerebral hemodynamics, especially in the bed of vertebral arteries. Results of a research have shown the importance of a vertebrogenic factor in the formation of DE. It is recommended to include an examination of the cervical part of a backbone in an algorithm of inspection of DE patients. By results of the factorial analysis arterial hypertensions fails to be the main and determining factor in the formation of DE, and only strengthens the influence of other factors.
Cellular and humoral components of the immune system of the skin
Authors: Makhneva Natalie V.
Published: September 2020

Along with mucous membranes the skin as the main barrier to the outside world creates a system of protection against any influences of the world. It is not only the place of realization of immunological processes, but it also actively participates in them due to the existence of its own elements of the immune system which are able to actively participate in the development of inflammatory reactions and neoplastic processes. Skin cells interact with cells of the immune system by setting a direct contact or by secreting a number of soluble factors, called cytokines, and other protein components such as proteins of the complement system. The general concept of skin-associated lymphoid tissue and skin’s immune system with immunocompetent cells in the epidermis and dermis, for cooperation of which in various stages of the immune response requires identity concerning anti-genes of HLA system, is presented in the review. Thus, specific immunological reaction with antibody formation promote the release of antigen from the body of both exogenous and endogenous origin. However, at violation of any element of immunological protection there is a delay of antigen elimination process, that results in own tissue structural damage. Interaction with foreign antigens (physical, chemical, infectious, etc.), denaturation of its own proteins or disclosure of tissue structures (antigens), that did not contact with immunocompetent cells, promote the formation of autoantigens and the production of autoantibodies against them. Thus, skin is a highly organized structure with a network of immunocompetent cells and soluble mediators. Introduction of molecular and biological methods as a knowledge tool is continually expanding the information about the skin as an organ of the immune system. The gained knowledge will definitely promote the development of new therapeutic approaches to skin diseases.
Expression proteaseinhibitors receptor PAR-2 on neutrophils peripheral blood of patients with atopic dermatitis and their relation with heat shock proteins HSP90
Authors: Elistratova I. V , Morozov Sergey G. , Zakharova I. A
Published: September 2020

Expression ofprotease-activated receptors PAR-2 has been investigated on neutrophils isolated from atopic dermatitis patient peripheral blood and has been analyzed with index SCORAD. The simultaneous expression of both, PAR-2 receptors and heat shock protein 90 (HSP90) was measured on neutrophils at the first week of acute phase of atopic dermatitis. Methods. Peripheral blood neutrophils were isolated on the Percoll gradient. Cells were stained with antibodies to PAR-2 receptor and HSP90 followed by the flow cytometry. Results. The PAR-2 receptors have been shown to be expressed on the plasma membrane of neutrophils obtained from patients with atopic dermatitis. The percentage of PAR-2+ neutrophils was positive correlated with diseases severity. HSP90 was found to be elevated simultaneously with PAR-2 receptors on neutrophils at the acute phase of atopic relapse. Conclusions. Atopic dermatitis patients have the higher level of PAR-2 receptor expression compared with healthy donors. Percentage of PAR-2+ neutrophils is elevated with the increasing of disease severity. Simultaneous elevation of PAR-2 receptors and HSP90 was found at the first week of acute atopic dermatitis.
The influence of peptide bioregulators on skin aging in 3D culture model
Authors: Kozhina K. V , Volkova E. N , Saburina I. N , Morozov Sergey G. , Zurina I. M , Kosheleva N. V , Gorkun A. A , Grigorieva A. A
Published: September 2020

He effect of mesotherapy injection (Meso-Wharton R199TM) on the dermal fibroblasts culture, simulating condition of (mature) aging skin cells are studied. Material and methods. The culture of 4th passage fibroblasts (P4), that corresponds to young skin fibroblasts (control) and the culture of 18th passage fibroblasts (P18), that has all the signs of aging dermal fibroblasts (predominance of large cells, slow cell division) were used. Bioactivity was assessed by cell morphology, epithelium-mesenchyme plasticity and expression of fibroblasts markers: cytokeratin 19, elastin, a-smooth muscle actin (aSMA), PCNA (proliferation marker), collagen types I, III, IV and fibronectin. The formation of spheroids occur when fibroblasts P18 are cultivating with the injection medication, on terms comparable to the formation of spheroids from P4 young fibroblasts. From culture of fibroblasts P18, that was cultured without medication, does not form the full spheroid, but aggregation of cells and their gradual destruction with necrotic masses within the unit are observed. The presence of the medication stimulates the “rejuvenation” of cells and subsequent recovery of the mesenchyme-epithelial plasticity of cultured fibroblasts due to the reduced ability to synthesize sufficient to establish the amount of intercellular contacts the extracellular matrix components (fibronectin and collagen), which affects the ability to form spheroids. Culturing spheroids formed with the medication stimulates expression of elastin, collagen type IV, fibronectin extracellular matrix protein that supports the skin elasticity and superficial cells actively express cytokeratin 19. The study results clearly demonstrate the effectiveness of mesotherapeutic treatment for skin rejuvenation.
A rare combination of inverse acne and infiltrative-productive stage of rosacea
Authors: Olisova O. Yu , Snarskaya E. S , Grabovskaya O. V , Tepluyk N. P , Lepekhova Anfisa A. , Gasymova A. S
Published: September 2020

The analysis of literature and exceptional clinical case of combination of inverse acne and infiltrative-productive stage of rosacea are presented. The historical facts, ethiopathogenesis, comorbidity, treatment, clinical picture and diagnostics with use of both standard and invasive methods of research (histological method) are described. Successful treatment of combination of inverse acne and an infiltrative-productive stage of rosacea with antibiotics and actinolyzat is reported.
Topical treatment of chronic dermatoses with kertoplastic agents
Authors: Grabovskaya O. V , Vertieva E. Yu , Shestakova L. A , Grekova Ekaterina V.
Published: September 2020

Atopic dermatitis and psoriasis are common chronic dermatosis characterized by prolonged recurrent course. Depending on the severity of the disease topical and systemic treatment are applied. Keratoplastic agents play an important role in treatment of skin diseases. These agents include Naftalan Cream 30%, which significantly improves the skin condition. The results of treatment of 10 patients with atopic dermatitis and 10 patients with psoriasis vulgaris Naftalan cream 30% are presented.