bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling and Development of Electrical Aptasensors: A Short Review
Authors: Cataldo Rosella , Leuzzi Maria , Alfinito Eleonora
Published: April 2018

Aptamers are strands of DNA or RNA molecules, chemically synthetized and able to bind a wide range of targets, from small molecules to live cells, and even tissues, with high affinity and specificity. Due to their efficient targeting ability, they have many different kinds of applications. Particularly attractive is their use in biotechnology and disease therapy, in substitution of antibodies. They represent a promising way for early diagnosis (aptasensors), but also for delivering imaging agents and drugs and for inhibiting specific proteins (therapeutic aptamers). Starting by briefly reviewing the most recent literature concerning advances in biomedical applications of aptamers and aptasensors, the focus is on the issues of a theoretical/computational framework (proteotronics) for modelling the electrical properties of biomolecules. Some recent results of proteotronics concerning the electrical, topological and affinity properties of aptamers are reviewed.
The Functionalization of Nanostructures and Their Potential Applications in Edible Coatings
Authors: González-Reza Ricardo , García-Betanzos Claudia , Sánchez-Valdes Liliana , Quintanar-Guerrero David , Cornejo-Villegas María , Zambrano-Zaragoza María
Published: April 2018

Nowadays, edible coatings incorporated with nanostructures as systems of controlled release of flavors, colorants and/or antioxidants and antimicrobial substances, also used for thermal and environmental protection of active compounds, represent a gap of opportunity to increase the shelf life of food highly perishable, as well as for the development of new products. These functionalized nanostructures have the benefit of incorporating natural substances obtained from the food industry that are rich in polyphenols, dietary fibers, and antimicrobial substances. In addition, the polymers employed on its preparation, such as polysaccharides, solid lipids and proteins that are low cost and developed through sustainable processes, are friendly to the environment. The objective of this review is to present the materials commonly used in the preparation of nanostructures, the main ingredients with which they can be functionalized and used in the preparation of edible coatings, as well as the advances that these structures have represented when used as controlled release systems, increasing the shelf life and promoting the development of new products that meet the characteristics of functionality for fresh foods ready to eat.
Sc2[Se2O5]3: The First Rare-Earth Metal Oxoselenate(IV) with Exclusively [Se2O5]2− Anions
Authors: Greiner Stefan , Schleid Thomas
Published: April 2018

The scandium oxodiselenate(IV) Sc2[Se2O5]3 was synthesized via solid-state reactions between scandium sesquioxide (Sc2O3) and selenium dioxide (SeO2) with thallium(I) chloride (TlCl) as fluxing agent in molar ratios of 1:4:2. Evacuated fused silica ampoules were used as reactions vessels for annealing the mixtures for five days at 800 °C. The new scandium compound crystallizes in the triclinic space group P 1 ¯ with the lattice parameters a = 663.71(5) pm, b = 1024.32(7) pm, c = 1057.49(8) pm, α = 81.034(2)°, β = 87.468(2)°, γ = 89.237(2)° and Z = 2. There are two distinct Sc3+ positions, which show six-fold coordination by oxygen atoms as [ScO6]9− octahedra (d(Sc–O) = 205–212 pm). Three different [Se2O5]2− anions provide these oxygen atoms with their terminal ligands (Ot). Each of the six selenium(IV) central atoms exhibit a stereochemically active lone pair of electrons, so that all [Se2O5]2− anions consist of two ψ1-tetrahedral [SeO3]2− subunits (d(Se–Ot) = 164–167 pm, d(Se–Ob) = 176–185 pm, ∢(O–Se–O) = 93–104°) sharing one bridging oxygen atom (Ob) with ∢(Se–Ob–Se) = 121–128°. The vibrational modes of the complex anionic [Se2O5]2− entities were characterized via single-crystal Raman spectroscopy.
Analysis of Waveguides on Lithium Niobate Thin Films
Authors: Wang Yiwen , Chen Zhihua , Hu Hui
Published: April 2018

Waveguides formed by etching, proton-exchange (PE), and strip-loaded on single-crystal lithium niobate (LN) thin film were designed and simulated by a full-vectorial finite difference method. The single-mode condition, optical power distribution, and bending loss of these kinds of waveguides were studied and compared systematically. For the PE waveguide, the optical power distributed in LN layer had negligible change with the increase of PE thickness. For the strip-loaded waveguide, the relationships between optical power distribution in LN layer and waveguide thickness were different for quasi-TE (q-TE) and quasi-TM (q-TM) modes. The bending loss would decrease with the increase of bending radius. There was a bending loss caused by the electromagnetic field leakage when the neff of q-TM waveguide was smaller than that of nearby TE planar waveguide. LN ridge waveguides possessed a low bending loss even at a relatively small bending radius. This study is helpful for the understanding of waveguide structures as well as for the optimization and the fabrication of high-density integrated optical components.
Quantifying Configuration-Sampling Error in Langevin Simulations of Complex Molecular Systems
Authors: Fass Josh , Sivak David A. , Crooks Gavin E. , Beauchamp Kyle A. , Leimkuhler Benedict , Chodera John D.
Published: April 2018

While Langevin integrators are popular in the study of equilibrium properties of complex systems, it is challenging to estimate the timestep-induced discretization error: the degree to which the sampled phase-space or configuration-space probability density departs from the desired target density due to the use of a finite integration timestep. Sivak et al., introduced a convenient approach to approximating a natural measure of error between the sampled density and the target equilibrium density, the Kullback-Leibler (KL) divergence, in phase space, but did not specifically address the issue of configuration-space properties, which are much more commonly of interest in molecular simulations. Here, we introduce a variant of this near-equilibrium estimator capable of measuring the error in the configuration-space marginal density, validating it against a complex but exact nested Monte Carlo estimator to show that it reproduces the KL divergence with high fidelity. To illustrate its utility, we employ this new near-equilibrium estimator to assess a claim that a recently proposed Langevin integrator introduces extremely small configuration-space density errors up to the stability limit at no extra computational expense. Finally, we show how this approach to quantifying sampling bias can be applied to a wide variety of stochastic integrators by following a straightforward procedure to compute the appropriate shadow work, and describe how it can be extended to quantify the error in arbitrary marginal or conditional distributions of interest.
ϕ-Divergence in Contingency Table Analysis
Authors: Kateri Maria
Published: April 2018

The ϕ -divergence association models for two-way contingency tables is a family of models that includes the association and correlation models as special cases. We present this family of models, discussing its features and demonstrating the role of ϕ -divergence in building this family. The most parsimonious member of this family, the model of ϕ -scaled uniform local association, is considered in detail. It is implemented and representative examples are commented on.
Autonomous Vehicles for Smart and Sustainable Cities: An In-Depth Exploration of Privacy and Cybersecurity Implications
Authors: Lim Hazel Si Min , Taeihagh Araz
Published: April 2018

Amidst rapid urban development, sustainable transportation solutions are required to meet the increasing demands for mobility whilst mitigating the potentially negative social, economic, and environmental impacts. This study analyses autonomous vehicles (AVs) as a potential transportation solution for smart and sustainable development. We identified privacy and cybersecurity risks of AVs as crucial to the development of smart and sustainable cities and examined the steps taken by governments around the world to address these risks. We highlight the literature that supports why AVs are essential for smart and sustainable development. We then identify the aspects of privacy and cybersecurity in AVs that are important for smart and sustainable development. Lastly, we review the efforts taken by federal governments in the US, the UK, China, Australia, Japan, Singapore, South Korea, Germany, France, and the EU, and by US state governments to address AV-related privacy and cybersecurity risks in-depth. Overall, the actions taken by governments to address privacy risks are mainly in the form of regulations or voluntary guidelines. To address cybersecurity risks, governments have mostly resorted to regulations that are not specific to AVs and are conducting research and fostering research collaborations with the private sector.
Energy Management for Community Energy Network with CHP Based on Cooperative Game
Authors: Liu Xiaofeng , Wang Shijun , Sun Jiawen
Published: April 2018

Integrated energy system (IES) has received increasing attention in micro grid due to the high energy efficiency and low emission of carbon dioxide. Based on the technology of combined heat and power (CHP), this paper develops a novel operation mechanism with community micro turbine and shared energy storage system (ESS) for energy management of prosumers. In the proposed framework, micro-grid operator (MGO) equipped with micro turbine and ESS provides energy selling business and ESS leasing business for prosumers. Prosumers can make energy trading with public grid and MGO, and ESS will be shared among prosumers when they pay for the rent to MGO. Based on such framework, we adopt a cooperative game for prosumers to determine optimal energy trading strategies from MGO and public grid for the next day. Concretely, a cooperative game model is formulated to search the optimal strategies aiming at minimizing the daily cost of coalition, and then a bilateral Shapley value (BSV) is proposed to solve the allocation problem of coalition’s cost among prosumers. To verify the effectiveness of proposed energy management framework, a practical example is conducted with a community energy network containing MGO and 10 residential buildings. Simulation results show that the proposed scheme is able to provide financial benefits to all prosumers, while providing peak load leveling for the grid.
Effects of Near Natural Forest Management on Soil Greenhouse Gas Flux in Pinus massoniana (Lamb.) and Cunninghamia lanceolata (Lamb.) Hook. Plantations
Authors: Ming Angang , Yang Yujing , Liu Shirong , Wang Hui , Li Yuanfa , Li Hua , Nong You , Cai Daoxiong , Jia Hongyan , Tao Yi , Sun Dongjing
Published: April 2018

Greenhouse gases are the main cause of global warming, and forest soil plays an important role in greenhouse gas flux. Near natural forest management is one of the most promising options for improving the function of forests as carbon sinks. However, its effects on greenhouse gas emissions are not yet clear. It is therefore necessary to characterise the effects of near natural forest management on greenhouse gas emissions and soil carbon management in plantation ecosystems. We analysed the influence of near natural management on the flux of three major greenhouse gases (carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O)) in Pinus massoniana Lamb. and Cunninghamia lanceolata (Lamb.) Hook. plantations. The average emission rates of CO2 and N2O in the near natural plantations were higher than those in the corresponding unimproved pure plantations of P. massoniana and C. lanceolata, and the average absorption rate of CH4 in the pure plantations was lower than that in the near natural plantations. The differences in the CO2 emission rates between plantations could be explained by differences in the C:N ratio of the fine roots. The differences in the N2O emission rates could be attributed to differences in soil available N content and the C:N ratio of leaf litter, while the differences in CH4 uptake rate could be explained by differences in the C:N ratio of leaf litter only. Near natural forest management negatively affected the soil greenhouse gas emissions in P. massoniana and C. lanceolata plantations. The potential impact of greenhouse gas flux should be considered when selecting tree species for enrichment planting.
Heroes and Cowards: Genealogy, Subjectivity and War in the Twenty-First Century
Authors: Lee Peter
Published: April 2018

From the wars of Ancient Greece to the collapsing Islamic State in the present, the same, apparently timeless protagonists appear and their stories told and re-told: the heroes, cowards and other combatants. This article proposes a framework which combines a Foucauldian genealogical approach with his conception of the subject as both constituted in relation to code-oriented moralities, and creatively self-formed in relation to ethics-oriented moralities (Foucault 1992, pp. 5, 25), to understand how it is possible to speak meaningfully of heroes and cowards in the age of the drone and the jihadist. Section one will explore the applicability of Foucauldian genealogy as the methodological basis for understanding present combatants in the context of war. The second section will assess Foucault’s ‘modes of subjectivation’ and ‘practices of the self’ (Foucault 1992, p. 28), as a means of analyzing the emergence of the subject of war over millennia, with emphasis on the ethical dimension of subjectivity that can be applied to heroes and cowards. Then the third section will use insights from Homer and Augustine to begin to illustrate how Foucault’s genealogical approach and his conception of ethical subjectivity combine to enable heroes and cowards to be meaningfully spoken of and better understood in the domain of war today. The purpose of such a study is to set out the basis on which political genealogy after Foucault can provide a nuanced conceptualization of subjectivity in modern war, as those subjects are formed, claimed, valorized and criticized by competing entities in contemporary political discourse.
Transport of Mineral Dust and Its Impact on Climate
Authors: Schepanski Kerstin
Published: April 2018

Mineral dust plays a pivotal role in the Earth’s system. Dust modulates the global energy budget directly via its interactions with radiation and indirectly via its influence on cloud and precipitation formation processes. Dust is a micro-nutrient and fertilizer for ecosystems due to its mineralogical composition and thus impacts on the global carbon cycle. Hence, dust aerosol is an essential part of weather and climate. Dust suspended in the air is determined by the atmospheric dust cycle: Dust sources and emission processes define the amount of dust entrained into the atmosphere. Atmospheric mixing and circulation carry plumes of dust to remote places. Ultimately, dust particles are removed from the atmosphere by deposition processes such as gravitational settling and rain wash out. During its residence time, dust interacts with and thus modulates the atmosphere resulting into changes such as in surface temperature, wind, clouds, and precipitation rates. There are still uncertainties regarding individual dust interactions and their relevance. Dust modulates key processes that are inevitably influencing the Earth energy budget. Dust transport allows for these interactions and at the same time, the intermittency of dust transport introduces additional fluctuations into a complex and challenging system.
A Prospective Study on the Influence of Scholastic Factors on the Prevalence and Initiation of Illicit Drug Misuse in Adolescence
Authors: Zubak Zoran , Zenic Natasa , Ostojic Ljerka , Zubak Ivana , Pojskic Haris
Published: April 2018

Background: This study aimed to prospectively investigate the scholastic factors related to illicit drug misuse (IDM) and the initiation of IDM among older adolescents from Bosnia and Herzegovina. Methods: This 2-year prospective study included 436 participants (202 females), who were an average of 16 years old at the beginning of the study (baseline). The participants were tested at baseline and follow-up (20 months later). The predictors included variables of scholastic-achievement (grade point average, school absences, unexcused absences and behavioral grade). The criteria were: (i) IDM at baseline; (ii) IDM at follow-up; and (iii) initiation of IDM over the study course. Results: Logistic regression indicated increased odds of IDM in adolescents who were more frequent absent from school (baseline: Odds Ratio (OR): 3.73, 95% Confidence Interval (CI): 2.12–6.57; follow-up: OR: 2.91, 95% CI: 1.90–4.65). The lower grade point average and more unexcused absences were evidenced for adolescents who consumed drugs on follow-up (OR: 1.67, 95% CI: 1.11–2.51; OR: 1.74, 95% CI: 1.30–2.32 for grade point average and unexcused absences, respectively). Initiation of IDM was predicted by frequent absences from school (OR: 2.2, 95% CI: 1.3–3.8), and lower behavioral grades (OR: 1.9, 95% CI: 1.2–3.3). Conclusions: The findings confirmed strong correlations between scholastic failure and IDM. Absences from school and lower behavioral grades at baseline were predictive of the initiation of IDM in older adolescents.
Fabrication of Metal-Substituted Polyoxometalates for Colorimetric Detection of Dopamine and Ractopamine
Authors: Duan Xixin , Bai Zhixian , Shao Xueting , Xu Jian , Yan Ning , Shi Junyou , Wang Xiaohong
Published: April 2018

A novel colorimetric detection method based on the peroxidase-like activity of metal-substituted polyoxometalates (POMs) of SiW9M3 (M = Co2+, Fe3+, Cu2+, Mn2+) has been established. POMs can catalyze oxidation of dopamine (DA) and ractopamine (RAC) by H2O2 in aqueous solutions. SiW9Co3-based POMs detect DA at concentrations as low as 5.38 × 10−6 mol·L−1 simply by observation of the color change from colorless to orange using the naked eye. RAC is detected by observing the change from colorless to slight red by SiW9Cu3 with a detection limit of 7.94 × 10−5 mol·L−1. This study shows that colorimetric DA and RAC detection using SiW9Co3 and SiW9Cu3 is highly selective and sensitive as well as visually observable.
Research on the Single Grit Scratching Process of Oxygen-Free Copper (OFC)
Authors: Zhang Libin , Zhang Tao , Guo Bicheng , Yan Lan , Jiang Feng
Published: April 2018

Single grit scratching is a basic form of material removal for many processes, such as grinding single point diamond turning and coating bonding performance tests. It has been widely used in the study of micro-scale and nano-scale material removal mechanisms. In this study, single grit linearly loading scratching tests were carried out on a scratching tester. A Rockwell indenter made of natural diamond was selected as the tool used, and the material of the workpiece was oxygen-free copper. Scratch topography was measured using a super-depth microscope to analyze the material deformation of the scratching process. A single grit scratching simulation has been developed by AdvantEdge™ to comprehensively study the material deformation of scratching processes. A material constitutive model and friction model were acquired using a quasi-static uniaxial compression experiment and a reciprocating friction test, respectively. These two models were used as the input models in the finite simulations. The simulated scratching forces aligned well with the experimental scratching forces, which verified the precision of the simulation model. Since only the scratching force could be obtained in the scratching experiment, the plastic strain, material flow, and residual stress of the scratching were further analyzed using simulations. The results showed that the plastic strain of the workpiece increased with the increase in scratching depth, and further analysis showed that the workpiece surface was distributed with residual compressive stress and the sub-surface was distributed with residual tensile stress in single grit scratching.
Haliotis discus discus Sialic Acid-Binding Lectin Reduces the Oncolytic Vaccinia Virus Induced Toxicity in a Glioblastoma Mouse Model
Authors: Li Gongchu , Mei Shengsheng , Cheng Jianhong , Wu Tao , Luo Jingjing
Published: April 2018

Although oncolytic viruses provide attractive vehicles for cancer treatment, their adverse effects are largely ignored. In this work, rat C6 glioblastoma cells were subcutaneously xenografted into mice, and a thymidine kinase-deficient oncolytic vaccinia virus (oncoVV) induced severe toxicity in this model. However, oncoVV-HddSBL, in which a gene encoding Haliotis discus discus sialic acid-binding lectin (HddSBL) was inserted into oncoVV, significantly prolonged the survival of mice as compared to the control virus. HddSBL reduced the tumor secreted serum rat IL-2 level upregulated by oncoVV, promoted viral replication, as well as inhibited the expression of antiviral factors in C6 glioblastoma cell line. Furthermore, HddSBL downregulated the expression levels of histone H3 and H4, and upregulated histone H3R8 and H4R3 asymmetric dimethylation, confirming the effect of HddSBL on chromatin structure suggested by the transcriptome data. Our results might provide insights into the utilization of HddSBL in counteracting the adverse effects of oncolytic vaccinia virus.
Isolated Nasal Amyloidosis: A Case Report
Authors: Rauba Darius , Lesinskas Eugenijus , Petrulionis Mindaugas , Sukyte Donata , Valeviciene Nomeda , Palionis Darius , Tamosiinas Algirdas
Published: April 2018

Amyloidosis is a rare condition characterized by the deposition of abnormal protein filaments into the extracellular tissue. Only 16 cases of true primary idiopathic amyloidosis local- ized in the nose and the paranasal sinuses have previously been reported. We present a case of local- ized amyloidosis involving the sinonasal cavities and the nose in a 53-year-old woman. Our patient was operated on as a typical case of chronic rhinosinusitis with polyps, but after 2 years, the patient came back with severe symptoms of nasal obstruction and pain in the frontal and maxillary regions with proptosis of both eyes. Magnetic resonance imaging revealed sinonasal-intraorbital masses. Primary amyloidosis (AL type) was confirmed by tissue biopsy. A systemic workup for additional amyloid deposits revealed no evidence of other diseases. Extended surgery produced a symptomatic improvement.
Study of the Carrier-Aided Thin Film Electrode Array Design for Cochlear Insertion
Authors: Xu Yuchen , Luo Chuan , Zeng Fan-Gang , Middlebrooks John C. , Lin Harrison W. , You Zheng
Published: April 2018

The micro-fabricated thin film electrode array (TFEA) has been a promising design for cochlear implants (CIs) because of its cost-effectiveness and fabrication precision. The latest polymer-based cochlear TFEAs have faced difficulties for cochlear insertion due to the lack of structural stiffness. To stiffen the TFEA, dissolvable stiffening materials, TFEAs with different structures, and TFEAs with commercial CIs as carriers have been invested. In this work, the concept of enhancing a Parylene TFEA with Kapton tape as a simpler carrier for cochlear insertion has been proved to be feasible. The bending stiffness of the Kapton-aided TFEA was characterized with an analytical model, a finite element model, and a cantilever bending experiment, respectively. While the Kapton tape increased the bending stiffness of the Parylene TFEA by 103 times, the 6-μm-thick TFEA with a similar Young’s modulus, as a polyimide, in turn significantly increased the bending stiffness of the 170-μm-thick Kapton carrier by 60%. This result indicated that even the TFEA is ultra-flexible and that its bending stiffness should not be neglected in the design or selection of its carrier.
Effects of 200 Gy 60Co-γ Radiation on the Regulation of Antioxidant Enzymes, Hsp70 Genes, and Serum Molecules of Plutella xylostella (Linnaeus)
Authors: Li Xiaoxue , Luo Lingyan , Karthi Sengodan , Zhang Ke , Luo Jianjun , Hu Qiongbo , Weng Qunfang
Published: April 2018

The diamondback moth, Plutella xylostella (Linnaeus), is one of the notorious pests causing substantial loses to many cruciferous vegetables across the nations. The effects of 60Co-γ radiation on physiology of P. xylostella were investigated and the results displayed that 200 Gy irradiation significantly alters the antioxidant enzyme regulation in six-day-old male pupae of P. xylostella. First, in our research, we detected Oxidase system and stress response mechanism of irradiated pupae, the results displayed that 200 Gy irradiation significantly alters the antioxidant enzyme regulation in six-day-old male pupae of P. xylostella. The levels of superoxide dismutase (SOD) and catalase (CAT) were increased significantly in contrast the level of peroxidase (POD) and glutathione S-transferase (GST) were decreased in 12–24 h post-treatment. The heat shock proteins (Hsps) gene expression level was significant increasing, maximum > 2-folds upregulation of genes were observed in peak. However, they also had a trend of gradual recovery with development. Second, we detected the testis lactate dehydrogenase (LDH) and acid phosphatase (ACP) activity found that in male adults testis they increased significantly than control during its development. Thus the present research investigation highlights that the 60Co-γ radiation treatments alters the physiological development of diamondback moth. The results showed that 200 Gy dosage resulted in stress damage to the body and reproductive system of the diamondback moth.
A Chemical Investigation of the Leaves of Morus alba L.
Authors: Chen Xiao-yan , Zhang Ting , Wang Xin , Hamann Mark T. , Kang Jie , Yu De-quan , Chen Ruo-yun
Published: April 2018

The leaves of Morus alba L. are an important herbal medicine in Asia. The systematic isolation of the metabolites of the leaves of Morus alba L. was achieved using a combination of liquid chromatography techniques. The structures were elucidated by spectroscopic data analysis and the absolute configuration was determined based on electronic circular dichroism (ECD) spectroscopic data and hydrolysis experiments. Their biological activity was evaluated using different biological assays, such as the assessment of their capacity to inhibit the aldose reductase enzyme; the determination of their cytotoxic activity and the evaluation of their neuroprotective effects against the deprivation of serum or against the presence of nicouline. Chemical investigation of the leaves of Morus alba L. resulted in four new structures 1–4 and a known molecule 5. Compounds 2 and 5 inhibited aldose reductase with IC50 values of 4.33 μM and 6.0 μM compared with the potent AR inhibitor epalrestat (IC50 1.88 × 10−3 μM). Pretreatment with compound 3 decreased PC12 cell apoptosis subsequent serum deprivation condition and pretreatment with compound 5 decreased nicouline-induced PC12 cell apoptosis as compared with control cells (p < 0.001).
Anthocidins A–D, New 5-Hydroxyanthranilic Acid Related Metabolites from the Sea Urchin-Associated Actinobacterium, Streptomyces sp. HDa1
Authors: Guo Zhi-Kai , Wang Rong , Chen Shi-Quan , Chen Fu-Xiao , Liu Tian-Mi , Yang Ming-Qiu
Published: April 2018

Four new 5-hydroxyanthranilic acid related compounds, named anthocidins A–D (1–4), two known analogues n-lauryl 5-hydroxyanthranilate (5) and isolauryl 5-hydroxyanthranilate (6), together with benzamide (7), 3-hydroxy-4-methoxycinnamamide (8), and (3S-cis)-hexahydro-3-[(3,4-dihydroxyphenyl)methyl]pyrrolo[1,2-a]pyrazine-1,4-dione (9), were isolated from the fermentation broth of the marine-derived actinomycete, Streptomyces sp. HDa1, which was isolated from the gut of a sea urchin, Anthocidaris crassispina, collected from Hainan Island, China. The structures of these secondary metabolites were elucidated on the basis of their 1D and 2D-NMR and mass spectroscopic data, and anthocidin A was confirmed by single-crystal X-ray diffraction with Cu Kα radiation. Anthocidins A–D (1–4) feature an acetyl group substitution at the amino group and varying alkyl side chains at the carboxyl group of 5-hydroxyanthranilic acid, and compound 5 was isolated as a natural product for the first time. The cytotoxic and antibacterial activity of compounds 1–9 were evaluated.
A Novel Immersive VR Game Model for Recontextualization in Virtual Environments: The μVRModel
Authors: Fanini Bruno , Pagano Alfonsina , Ferdani Daniele
Published: April 2018

In recent years, immersive VR had a great boost in terms of adoption and research perspectives, especially those regarding the serious gaming universe. Within the cultural heritage field, virtual re-contextualization of items is a crucial task to be accomplished by individuals to understand a 3D reconstructed environment as a whole and to assign a meaning and a value to a specific cultural object. Immersive VR and consumer HMDs still present several issues related to motion sickness and locomotion: the interest in real-walking techniques outperforming other locomotion methods is growing year by year, although limited by physical constraints, higher costs, or current technology. In this work, we propose a novel game model (μVR) that combines real-walking techniques and an adaptive, game-driven, multi-scale progression to craft immersive re-contextualization applications. The presented model aims to minimize motion sickness while fully exploiting the physical tracked area and augmenting the understanding of what the user is experiencing at different world scales. We define and formalize the μVR model and its components mathematically for the sake of reproducibility, then we present results from a pilot test planned to validate the model on real users. Results assure the usability and effectiveness of VR model even if further implementation needs to be done.
Characterization of Silver Nanomaterials Derived from Marine Streptomyces sp. Al-Dhabi-87 and Its In Vitro Application against Multidrug Resistant and Extended-Spectrum Beta-Lactamase Clinical Pathogens
Authors: Al-Dhabi Naif Abdullah , Mohammed Ghilan Abdul-Kareem , Arasu Mariadhas Valan
Published: April 2018

A novel antagonistic marine Streptomyces sp. Al-Dhabi-87 that was recovered from the Gulf region of Saudi Arabia was used to synthesize silver nanoparticles (NP) from the culture free extract. The produced NP were confirmed by UV-visible spectroscopy (UV-Vis), high-resolution scanning electron microscope (HRSEM), transmission electron microscope (TEM), Fourier-transform infrared spectroscopy (FTIR), Energy Dispersive Spectroscopy (EDAX), and X-ray Powder Diffraction (XRD), and broth micro dilution techniques were employed for the determination of minimum inhibitory concentrations (MIC) values. The synthesized NP was authenticated by alterations in color and wavelength scanning. HRSEM and TEM analysis confirmed that the size of the NP ranged from 10 to 17 nm and that it was spherical in shape. In addition, the FTIR spectrum revealed a variation in the band values from 500 to 3300 cm−1 respectively. Rietveld refinement analysis of the XRD data confirmed the size of the NP, which coincided with the results of the TEM analysis. In addition, the Riveted refinement analysis supported the TEM data. The NP documented significant activity against the wound infection microbial strains, such as Enterococcus faecalis, Staphylococcus epidermidis, and Staphylococcus aureus. Gram negative bacteria, such as Pseudomonas aeruginosa, Klebsiella pneumonia, and Escherichia coli revealed MIC values of 0.039, 0.078, and 0.152 mg/mL, respectively. The promising activity of NP towards extended-spectrum beta-lactamases E.coli, drug resistant Acinetobacter baumannii, and multidrug resistant S. aureus (at 0.018, 0.039, and 0.039 mg/mL, respectively) was advantageous. Overall, NP that were obtained from the novel Streptomyces sp. Al-Dhabi-87, with its promising antimicrobial activity towards the drug resistant pathogens, would be useful for healing infectious diseases.
Electronic and Magnetic Properties of Ni-Doped Zinc-Blende ZnO: A First-Principles Study
Authors: Xue Suqin , Zhang Fuchun , Zhang Shuili , Wang Xiaoyang , Shao Tingting
Published: April 2018

The electronic structure, band structure, density of state, and magnetic properties of Ni-doped zinc-blende (ZB) ZnO are studied by using the first-principles method based on the spin-polarized density-functional theory. The calculated results show that Ni atoms can induce a stable ferromagnetic (FM) ground state in Ni-doped ZB ZnO. The magnetic moments mainly originate from the unpaired Ni 3d orbitals, and the O 2p orbitals contribute a little to the magnetic moments. The magnetic moment of a supercell including a single Ni atom is 0.79 μB. The electronic structure shows that Ni-doped ZB ZnO is a half-metallic FM material. The strong spin-orbit coupling appears near the Fermi level and shows obvious asymmetry for spin-up and spin-down density of state, which indicates a significant hybrid effects from the Ni 3d and O 2p states. However, the coupling of the anti-ferromagnetic (AFM) state show metallic characteristic, the spin-up and spin-down energy levels pass through the Fermi surface. The magnetic moment of a single Ni atom is 0.74 μB. Moreover, the results show that the Ni 3d and O 2p states have a strong p-d hybridization effect near the Fermi level and obtain a high stability. The above theoretical results demonstrate that Ni-doped zinc blende ZnO can be considered as a potential half-metal FM material and dilute magnetic semiconductors.
Enteral Nutrition in the Management of Pediatric and Adult Crohn’s Disease
Authors: Hansen Tawnya , Duerksen Donald R.
Published: April 2018

Genetic and environmental factors are thought to profoundly influence the pathophysiology of Crohn’s disease (CD). Changes in dietary and hygiene patterns affect the interactions between the immune system and environment. The gut microbiome is responsible for mediating host immune response with significant dysbiosis observed in individuals with CD. Diet therapy using exclusive enteral nutrition (EEN) has been studied as primary therapy for the management of CD. EEN may cultivate the presence of beneficial microbiota, improve bile acid metabolism, and decrease the number of dietary microparticles possibly influencing disease and immune activity. In this review, we will address the current evidence on EEN in the management of adult and pediatric CD. In adults, EEN appears to be moderately beneficial for the induction of remission of CD; however, its use is understudied and underutilized. Stronger evidence is in place to support the use of EEN in pediatric CD with the added benefit of nutrition support and steroid-sparing therapy during the growth phase. Overall, EEN is an established therapy in inducing CD remission in the pediatric population while its role as primary therapy of adult Crohn’s disease remains to be defined.
Improvement of the Multi-Hierarchy Simulation Model Based on the Real-Space Decomposition Method
Authors: Usami Shunsuke , Horiuchi Ritoku , Ohtani Hiroaki , Den Mitsue
Published: April 2018

Multi-hierarchy simulation models aimed at analysis of magnetic reconnection were developed. Based on the real-space decomposition method, the simulation domain consists of three parts: a magnetohydrodynamics (MHD) domain, a particle-in-cell (PIC) domain, and an interface domain to communicate MHD and PIC data. In this paper, the previous model (the 1D interlocking with the upstream condition) by the authors is improved to three types of new models, i.e., two types of the 1D interlocking with the downstream condition and one type of the 2D interlocking with the upstream condition. For their verification, simulations of plasma propagation across the multiple domains were performed in the multi-hierarchy models, and it was confirmed that the new interlocking methods are physically correct.
A Distance Bounding Protocol for Location-Cloaked Applications
Authors: Molina-Martínez Cristián , Galdames Patricio , Duran-Faundez Cristian
Published: April 2018

Location-based services (LBSs) assume that users are willing to release trustworthy and useful details about their whereabouts. However, many location privacy concerns have arisen. For location privacy protection, several algorithms build a cloaking region to hide a user’s location. However, many applications may not operate adequately on cloaked locations. For example, a traditional distance bounding protocol (DBP)—which is run by two nodes called the prover and the verifier—may conclude an untight and useless distance between these two entities. An LBS (verifier) may use this distance as a metric of usefulness and trustworthiness of the location claimed by the user (prover). However, we show that if a tight distance is desired, traditional DBP can refine a user’s cloaked location and compromise its location privacy. To find a proper balance, we propose a location-privacy-aware DBP protocol. Our solution consists of adding some small delays before submitting any user’s response. We show that several issues arise when a certain delay is chosen, and we propose some solutions. The effectiveness of our techniques in balancing location refinement and utility is demonstrated through simulation.
Fool’s Gold: Understanding Social, Economic and Environmental Impacts from Gold Mining in Quang Nam Province, Vietnam
Authors: Nguyen Nhi , Boruff Bryan , Tonts Matthew
Published: April 2018

Extractive industries are often claimed to contribute to both poverty reduction and economic growth. Yet, there is also a body of research that suggests natural resource dependence can result in limited development, environmental degradation and social upheaval. This paper examines differences in the socioeconomic and environmental state of mining and non-mining communities in rural Vietnam in order to understand the extent to which mining contributes to livelihood development and socioeconomic well-being. In particular, we examine the role that “corporate social responsibility” (CSR) plays in supporting community development in Phuoc Son and Phu Ninh districts, Quang Nam province. Content analysis of newspapers, government documents and mining company reports provided a contextual overview of mining operations and community relations in each study area. Semi-structured interviews were used to collect information from local and regional stakeholders to further understand perceived impacts of mining operations on local communities. Our study finds that in comparison to non-mining communities, communities with active mines demonstrated increased job development, decreased poverty rates, enhanced infrastructure and social development along with increased incidences of CSR initiatives. However, a number of adverse effects from mining activities were reported including environmental degradation (e.g., deforestation, water pollution, etc.) increased criminal activity and drug addiction. Dependence on mine-related employment in local communities becomes acutely apparent when temporary mine closures result in widespread unemployment. Local governments may be the greatest beneficiaries of mining with increased tax revenues and enhanced management potential of leased land. Non-mining communities without direct benefits from mining activities maintained economic diversity and were therefore more resilient to economic shocks such as nearby mine closures.
Efficacy from Different Extractions for Chemical Profile and Biological Activities of Rice Husk
Authors: Minh Truong Ngoc , Xuan Tran Dang , Ahmad Ateeque , Elzaawely Abdelnaser Abdelghany , Teschke Rolf , Van Truong Mai
Published: April 2018

Rice husk is a by-product produced abundantly in rice production but it has low commercial value and causes environmental pollution. This study was conducted to examine different extracting solvents and conditions to optimize the efficacy of antioxidant and antimicrobial potentials, and chemical components in rice husk. By the use of distilled water at 100 °C, the ethyl acetate (EtOAc) extract was potent in both total phenolic content (TPC), total flavonoid content (TFC), and DPPH scavenging activity. The treatment of either ethyl acetate (100 °C, 1 h), combined with MeOH 100%, showed the highest percent of lipid peroxidation inhibition (LPI) (86%), meaning that the strongest antioxidant activity was by the β-carotene bleaching method. The treatment of distilled water at room temperature possessed the strongest antioxidant activity in the assay of the reducing power. The use of dried samples at 100 °C for 2 h, combined with methanol (MeOH) 10%, provided the most potent antimicrobial activities against Escherichia coli, Klebsiella pneumoniae, Listeria monocytogenes, Bacillus subtilis, and Proteus mirabilis. The results suggested that the EtOAc extract from rice husk could be a potential source of natural antioxidants. In general, the use of temperature 100 °C for 2 h, combined with either EtOAc or 10% MeOH, can optimize chemical components and antioxidant and antimicrobial capacities in rice husk. Principal constituents putatively identified by gas chromatography–mass spectrometry (GC–MS) revealed the presence of momilactones A and B (MA and MB, respectively), phenols, phenolic acids, and long-chain fatty acids, although yields of these compounds varied among extracts. The bioactive MA and MB were found in most of the extracts, except distilled water and MeOH ≤ 50%, at any temperature. Findings of this study provided optimal conditions for future production at an industrial scale for rice husk to exploit its potent biological properties. It thus helps to increase the economic value and reduce the disposal burden and environmental troubles caused by rice husk.
Antepartum Fetal Monitoring through a Wearable System and a Mobile Application
Authors: Signorini Maria G. , Lanzola Giordano , Torti Emanuele , Fanelli Andrea , Magenes Giovanni
Published: April 2018

Prenatal monitoring of Fetal Heart Rate (FHR) is crucial for the prevention of fetal pathologies and unfavorable deliveries. However, the most commonly used Cardiotocographic exam can be performed only in hospital-like structures and requires the supervision of expert personnel. For this reason, a wearable system able to continuously monitor FHR would be a noticeable step towards a personalized and remote pregnancy care. Thanks to textile electrodes, miniaturized electronics, and smart devices like smartphones and tablets, we developed a wearable integrated system for everyday fetal monitoring during the last weeks of pregnancy. Pregnant women at home can use it without the need for any external support by clinicians. The transmission of FHR to a specialized medical center allows its remote analysis, exploiting advanced algorithms running on high-performance hardware able to obtain the best classification of the fetal condition. The system has been tested on a limited set of pregnant women whose fetal electrocardiogram recordings were acquired and classified, yielding an overall score for both accuracy and sensitivity over 90%. This novel approach can open a new perspective on the continuous monitoring of fetus development by enhancing the performance of regular examinations, making treatments really personalized, and reducing hospitalization or ambulatory visits.
The Application of a Multi-Beam Echo-Sounder in the Analysis of the Sedimentation Situation of a Large Reservoir after an Earthquake
Authors: Yan Zhong-Luan , Qin Lei-Lei , Wang Rui , Li Jia , Wang Xiao-Ming , Tang Xi-Liang , An Rui-Dong
Published: April 2018

The Wenchuan Earthquake took place in the upper reach catchment of the Min River. It resulted in large amounts of loose materials gathering in the river channel, leading to changes in the sediment transport system in this area. The Zipingpu Reservoir is the last and the largest reservoir located in the upper reach of the Min River. It is near the epicenter and receives sediment from upstream. This paper puts forward a study on the reservoir sedimentation and storage capacity of the Zipingpu Reservoir, employing a multi-beam echo-sounder system in December 2012. Then, the data were merged with digital line graphics and shuttle radar topography mission data in ArcGIS to build a digital elevation model and triangulate the irregular network of Zipingpu Reservoir. Via the analysis of the bathymetric data, the results show the following: (1) The main channels of the reservoir gradually aggrade to a flat bottom from the deep-cutting valley. Sedimentation forms a reach with a W-shaped longitudinal thalweg profile and an almost zero slope reach in the upstream section of the reservoir due to the natural barrier induced by a landslide; (2) The loss ratios of the wetted cross-section surface are higher than 10% in the upstream section of the reservoir and higher than 40% in the natural barrier area; (3) Comparing the surveyed area storage capacity of December 2012 with March 2008, the Zipingpu Reservoir has lost 15.28% of its capacity at the dead storage water level and 10.49% of its capacity at the flood limit water level.
Sentiment de sécurité de l’emploi : l’effet des indemnités chômage et de la justice prud’homale
Authors: Fraisse Henri , Prost Corinne , Rioux Laurence
Published: April 2018

Cet article analyse conjointement les effets de l’indemnisation chômage et de la justice prud’homale sur le sentiment de sécurité de l’emploi des salariés. L’échantillon français de l’ECHP (European Community Household Panel) fournit une mesure de la satisfaction des salariés vis-à-vis de la sécurité de leur emploi et permet de simuler les droits à l’assurance chômage de chacun d’eux. Les données sur les prud’hommes permettent en outre de construire plusieurs indicateurs de justice prud’homale au niveau des départements, dont le taux de victoire des salariés et la duréemoyenne des procédures. Nos résultats économétriques indiquent que la durée de l’indemnisation du chômage et les conditions de justice prud’homale améliorent la satisfaction des salariés vis-à-vis de la sécurité perçue de l’emploi.
Corrigenda: Han S-Y, Kim J-K, Kai Y, Senou H (2017) Seahorses of the Hippocampus coronatus complex: taxonomic revision, and description of Hippocampus haema, a new species from Korea and Japan (Teleostei, Syngnathidae). ZooKeys 712: 113–139. https://doi.org/10.3897/zookeys.712.14955
Authors: Han Sang-Yun , Kim Jin-Koo , Kai Yoshiaki , Senou Hiroshi
Published: April 2018

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Les pôles de compétitivité wallons
Authors: Dujardin Claire , Louis Virginie , Mayneris Florian
Published: April 2018

Cet article étudie l’impact de la politique wallonne des Pôles de compétitivité sur les performances économiques des entreprises financées. Sont considérés en particulier les effets sur la productivité, l’emploi et les exportations. L’analyse se base sur des micro-données d’entreprises couvrant l’ensemble des entreprises wallonnes et bruxelloises, pour la période 2003-2011. Nous recourons à des doubles et triples différences et à des méthodes de matching afin de solutionner les biais de sélection et de simultanéité. Les résultats suggèrent que, si la politique a bien sélectionné des entreprises plus performantes, elle n’aurait eu d’impact significatif ni sur la productivité, ni sur la valeur des exportations des entreprises bénéficiaires. Par contre, l’entrée dans le dispositif des Pôles coïnciderait avec une légère augmentation de l’emploi des entreprises financées et de leur valeur ajoutée brute l’année d’entrée dans le pôle, ainsi qu’avec une diversification de leur portefeuille de produits exportés. Classification JEL : C23, R10, R11, R58