bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of the Double Mutants on Spike Protein of SARS-CoV-2 B.1.617 Lineage on the Human ACE2 Receptor Binding: A Structural Insight
Authors: Khan Mohd Imran , Baig Mohammad Hassan , Mondal Tanmoy , Alorabi Mohammed , Sharma Tanuj , Dong Jae-June , Cho Jae Yong
Published: November 2021

The recent emergence of novel SARS-CoV-2 variants has threatened the efforts to contain the COVID-19 pandemic. The emergence of these “variants of concern” has increased immune escape and has supplanted the ancestral strains. The novel variants harbored by the B.1.617 lineage (kappa and delta) carry mutations within the receptor-binding domain of spike (S) protein (L452R + E484Q and L452R + T478K), the region binding to the host receptor. The double mutations carried by these novel variants are primarily responsible for an upsurge number of COVID-19 cases in India. In this study, we thoroughly investigated the impact of these double mutations on the binding capability to the human host receptor. We performed several structural analyses and found that the studied double mutations increase the binding affinity of the spike protein to the human host receptor (ACE2). Furthermore, our study showed that these double mutants might be a dominant contributor enhancing the receptor-binding affinity of SARS-CoV-2 and consequently making it more stable. We also investigated the impact of these mutations on the binding affinity of two monoclonal antibodies (Abs) (2-15 and LY-CoV555) and found that the presence of the double mutations also hinders its binding with the studied Abs. The principal component analysis, free energy landscape, intermolecular interaction, and other investigations provided a deeper structural insight to better understand the molecular mechanism responsible for increased viral transmissibility of these variants.
Investigating Adherence to COVID-19 Vaccination and Serum Antibody Concentration among Hospital Workers—The Experience of an Italian Private Hospital
Authors: Forgeschi Guglielmo , Cavallo Giuseppe , Lorini Chiara , Balboni Fiamma , Sequi Francesca , Bonaccorsi Guglielmo
Published: November 2021

SARS-CoV-2 transmission has been high, especially among healthcare workers worldwide during the first wave. Vaccination is recognized as the most effective approach to combat the pandemic, but hesitation to get vaccinated represents an obstacle. Another important issue is the duration of protection after administration of the full vaccination cycle. Based on these premises, we conducted a study to evaluate vaccination adherence and the anti-S antibodies levels among hospital workers, from January to March, 2021. To assess adherence, an anonymous questionnaire was used. Anti-S antibody levels were obtained from the monitoring serological sample database. In total, 56.2% of the unvaccinated people did not report a previous infection from COVID-19. Among those who have not been vaccinated, 12.5% showed distrust against the vaccine, 8.3% stated to have received contraindications to the vaccination, and 6.3% did not report any choice. Analyzing anti-S antibody levels, only one person was found to have a value below the lower cut-off, two weeks, and three months after receiving their second dose. One was below the cut-off after two weeks, and then above the same cut-off after three months. The results of our survey should be seen as a stimulus to further sensitize hospital staff to the importance of vaccination and pay attention to anti-S antibody levels monitoring.
Factors Associated with Attitudes towards Seasonal Influenza Vaccination in Poland: A Nationwide Cross-Sectional Survey in 2020
Authors: Samel-Kowalik Piotr , Jankowski Mateusz , Lisiecka-Biełanowicz Mira , Ostrowska Aurelia , Gujski Mariusz , Kobuszewski Bartosz , Pinkas Jarosław , Raciborski Filip
Published: November 2021

We aimed to assess attitudes towards the influenza vaccine and factors associated with a willingness to vaccinate against seasonal influenza in Poland during the COVID-19 pandemic (flu season 2020/2021). This cross-sectional questionnaire-based study was carried out between 5 and 15 November 2020 on a representative nationwide sample of 1052 individuals aged 18+ in Poland. Of the respondents, 5.5% (95% CI: 4.3–7.0%) declared that they had already got vaccinated against influenza and 13.4% (95% CI: 11.4–15.6%) declared a willingness to vaccinate against influenza during the 2020/2021 season. Out of nine different factors analyzed in this study, only three were significantly associated with attitudes towards influenza vaccination. Participants aged 75 years and over (OR = 5.82; 95% CI: 2.63–12.85), as well as participants aged 60–74 years (OR = 2.43; 95% CI: 1.30–4.54), compared to those aged 19–29, had significantly higher odds of having a positive attitude towards seasonal influenza vaccination. Respondents who define themselves as completely religious unbelievers (OR = 4.34; 95% CI: 1.79–10.55), as well as Internet users (OR = 2.12; 95% CI: 1.30–3.47), had higher odds of having a positive attitude towards influenza vaccination. Despite the COVID-19 pandemic, the percentage of adults in Poland who already got vaccinated or declared a willingness to vaccinate against influenza remains low. This also applies to high-risk groups.
Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in Mice and Non-Human Primates Is Diminished upon Recovery of the Gut Microbiome
Authors: Swaminathan Gokul , Citron Michael , Xiao Jianying , Norton James E. , Reens Abigail L. , Topçuoğlu Begüm D. , Maritz Julia M. , Lee Keun-Joong , Freed Daniel C. , Weber Teresa M. , White Cory H. , Kadam Mahika , Spofford Erin , Bryant-Hall Erin , Salituro Gino , Kommineni Sushma , Liang Xue , Danilchanka Olga , Fontenot Jane A. , Woelk Christopher H. , Gutierrez Dario A. , Hazuda Daria J. , Hannigan Geoffrey D.
Published: November 2021

Emerging evidence demonstrates a connection between microbiome composition and suboptimal response to vaccines (vaccine hyporesponse). Harnessing the interaction between microbes and the immune system could provide novel therapeutic strategies for improving vaccine response. Currently we do not fully understand the mechanisms and dynamics by which the microbiome influences vaccine response. Using both mouse and non-human primate models, we report that short-term oral treatment with a single antibiotic (vancomycin) results in the disruption of the gut microbiome and this correlates with a decrease in systemic levels of antigen-specific IgG upon subsequent parenteral vaccination. We further show that recovery of microbial diversity before vaccination prevents antibiotic-induced vaccine hyporesponse, and that the antigen specific IgG response correlates with the recovery of microbiome diversity. RNA sequencing analysis of small intestine, spleen, whole blood, and secondary lymphoid organs from antibiotic treated mice revealed a dramatic impact on the immune system, and a muted inflammatory signature is correlated with loss of bacteria from Lachnospiraceae, Ruminococcaceae, and Clostridiaceae. These results suggest that microbially modulated immune pathways may be leveraged to promote vaccine response and will inform future vaccine design and development strategies.
COVID-19 Vaccine Hesitancy in Healthcare Personnel: A University Hospital Experience
Authors: Kara Esen Beril , Can Gunay , Pirdal Betul Zehra , Aydin Sumeyye Nur , Ozdil Aysenur , Balkan Ilker Inanc , Budak Beyhan , Keskindemirci Yilmaz , Karaali Ridvan , Saltoglu Nese
Published: November 2021

Healthcare workers are among risk groups in the COVID-19. Even if they are not infected with the disease, they witness the effects of the pandemic. The aim of the study is to determine the factors affecting COVID-19 vaccination status and reasons for vaccine hesitancy of healthcare personnel in our hospital. Firstly, the vaccination status and demographic characteristics of all healthcare personnel was evaluated. After that, a survey was applied to 408 vaccinated and 297 nonvaccinated personnel. Within the first month after the beginning of vaccination, 66% of 3937 healthcare personnel received a COVID-19 vaccine. The number of vaccinated personnel was higher among doctors, master graduates or higher educational levels and basic science-laboratory unit workers. In the surveyed group, being under the age of 50 (OR:1.85), being nondoctor healthcare personnel (nurse/midwife OR:1.78, administrative personnel OR:3.42, patient attendant/cleaning staff OR:4.11, security guard/other OR:2.96), having had the disease before (OR:2.36), not having the flu vaccine (OR:3.24) and hesitancy about other vaccines (OR:6.61) were found to be independent risk factors for not having a COVID-19 vaccine or having it late. The three most common reasons for not getting vaccinated were doubt on the efficacy of the vaccine, distrust of its content, and fear of side effects. Taking steps by considering the main factors of hesitancy among healthcare personnel will increase the vaccine acceptance.
Development of a SARS-CoV-2 Vaccine Candidate Using Plant-Based Manufacturing and a Tobacco Mosaic Virus-like Nano-Particle
Authors: Royal Joshua M. , Simpson Carrie A. , McCormick Alison A. , Phillips Amanda , Hume Steve , Morton Josh , Shepherd John , Oh Youngjun , Swope Kelsi , DeBeauchamp Jennifer L. , Webby Richard J. , Cross Robert W. , Borisevich Viktoriya , Geisbert Thomas W. , Demarco Jennifer K. , Bratcher Barry , Haydon Hugh , Pogue Gregory P.
Published: November 2021

Stable, effective, easy-to-manufacture vaccines are critical to stopping the COVID-19 pandemic resulting from the coronavirus SARS-CoV-2. We constructed a vaccine candidate CoV-RBD121-NP, which is comprised of the SARS-CoV-2 receptor-binding domain (RBD) of the spike glycoprotein (S) fused to a human IgG1 Fc domain (CoV-RBD121) and conjugated to a modified tobacco mosaic virus (TMV) nanoparticle. In vitro, CoV-RBD121 bound to the host virus receptor ACE2 and to the monoclonal antibody CR3022, a neutralizing antibody that blocks S binding to ACE2. The CoV-RBD121-NP vaccine candidate retained key SARS-CoV-2 spike protein epitopes, had consistent manufacturing release properties of safety, identity, and strength, and displayed stable potency when stored for 12 months at 2–8 °C or 22–28 °C. Immunogenicity studies revealed strong antibody responses in C57BL/6 mice with non-adjuvanted or adjuvanted (7909 CpG) formulations. The non-adjuvanted vaccine induced a balanced Th1/Th2 response and antibodies that recognized both the S1 domain and full S protein from SARS2-CoV-2, whereas the adjuvanted vaccine induced a Th1-biased response. Both adjuvanted and non-adjuvanted vaccines induced virus neutralizing titers as measured by three different assays. Collectively, these data showed the production of a stable candidate vaccine for COVID-19 through the association of the SARS-CoV-2 RBD with the TMV-like nanoparticle.
Water Quality Index (WQI) as a Potential Proxy for Remote Sensing Evaluation of Water Quality in Arid Areas
Authors: Zhang Fei , Chan Ngai Weng , Liu Changjiang , Wang Xiaoping , Shi Jingchao , Kung Hsiang-Te , Li Xinguo , Guo Tao , Wang Weiwei , Cao Naixin
Published: November 2021

Water Resource Sustainability Management plays a vitally important role in ensuring sustainable development, especially in water-stressed arid regions throughout the world. In order to achieve sustainable development, it is necessary to study and monitor the water quality in the arid region of Central Asia, an area that is increasingly affected by climate change. In recent decades, the rapid deterioration of water quality in the Ebinur Lake basin in Xinjiang (China) has severely threatened sustainable economic development. This study selected the Ebinur Lake basin as the study target, with the purpose of revealing the response between the water quality index and water body reflectivity, and to describe the relationship between the water quality index and water reflectivity. The methodology employed remote sensing techniques that establish a water quality index monitoring model to monitor water quality. The results of our study include: (1) the Water Quality Index (WQI) that was used to evaluate the water environment in Ebinur Lake indicates a lower water quality of Ebinur Lake, with a WQI value as high as 4000; (2) an introduction of the spectral derivative method that realizes the extraction of spectral information from a water body to better mine the information of spectral data through remote sensing, and the results also prove that the spectral derivative method can improve the relationship between the water body spectral and WQI, whereby R2 is 0.6 at the most sensitive wavelengths; (3) the correlation between the spectral sensitivity index and WQI was greater than 0.6 at the significance level of 0.01 when multi-source spectral data were integrated with the spectral index (DI, RI and NDI) and fluorescence baseline; and (4) the distribution map of WQI in Ebinur Lake was obtained by the optimal model, which was constructed based on the third derivative data of Sentinel 2 data. We concluded that the water quality in the northwest of Ebinur Lake was the lowest in the region. In conclusion, we found that remote sensing techniques were highly effective and laid a foundation for water quality detection in arid areas.
Late Holocene Hydro-Climate Variability in the Eastern Mediterranean: A Spatial Multi-Proxy Approach
Authors: Bassukas Dimitrios , Emmanouilidis Alexandros , Avramidis Pavlos
Published: November 2021

A total of thirteen (13) paleoclimatic coastal and hinterland archives of the broader eastern Mediterranean region were collected and examined statistically in search of underlying trends for the period 2800 to 200 BP. For each archive, a proxy record representative of hydro-climatic changes was selected, normalized using z-factors to facilitate intercomparison, and analyzed statistically. Multivariate statistical analysis was performed using a clustering analysis (HCA) and dimension reduction (PCA), which led to groupings of similar records temporally, and allowed the identification of spatially underlying modes of variability. Two main modes of variability were identified, further supporting complex trajectories of paleoclimatic evolution in the region. The first mode was identified for sites presenting a trend from a wetter to an overall drier phase, with respective changes at major phase shifts at 1400 BP and 1100 BP. All sites were from the southern and northern Balkan region, as well as southwestern Turkey. A contrasting dry to wet trend was identified for a site in the Peloponnese (Greece) and the Levant, with a major phase shift at around 750 BP. The inclusion of different proxies from very different environmental settings and the 200-year window has complicated the connection of established short-term climatic events to the study’s findings.
The Catastrophe of the Niedów Dam—The Causes of the Dam’s Breach, Its Development, and Consequences
Authors: Kostecki Stanisław , Banasiak Robert
Published: November 2021

Due to extreme rainfall in 2010 in the Lusatian Neisse River catchment area (in Poland), a flood event with a return period of over 100 years occurred, leading to the failure of the Niedów dam. The earth-type dam constructed for cooling the Turów power plant was washed away, resulting in the rapid release of nearly 8.5 million m3 of water and the flooding of the downstream area with substantial material losses. Here we analyze the conditions and causes of the dam’s failure, with special attention given to the mechanism and dynamics of the compound breaching process, in which the dam’s upstream slope reinforcement played a specific and remarkable role. The paper also describes a numerical approach for simulating a combined flood event downstream from the dam with the use of a two-dimensional hydrodynamic model (MIKE21). Considering the specific local conditions, i.e., wide floodplain, meandering character of the main channel, embankment overtopping, and available data set, an iterative solution of the unsteady state problem is proposed. This approach enables realistic flood propagation estimates to be delivered, the dam breach outflow to be reconstructed, and several important answers concerning the consequences of the dam’s failure to be provided. Finally, the paper presents the reconstruction of the dam that is more resilient to extreme hydrological conditions under changing climate.
Health Risk of the Shallow Groundwater and Its Suitability for Drinking Purpose in Tongchuan, China
Authors: Nsabimana Abel , Li Peiyue , He Song , He Xiaodong , Alam S. M. Khorshed , Fida Misbah
Published: November 2021

Studying the quality and health risks of groundwater is of great significance for sustainable water resources utilization, especially in arid and semi-arid areas around the world. The current study is carried out to evaluate the quality and potential health risks of groundwater in the Tongchuan area on the Loess Plateau, northwest China. Water quality index (WQI) and hydrochemical correlation analysis were implemented to understand the status of groundwater quality. Daily average exposure dosages through the oral and dermal contact exposure pathways were taken into consideration to calculate the health risks to the human body. Additionally, graphical approaches such as Piper diagram, Durov diagram and GIS mapping were used to help better understand the results of this study. The WQI approach showed that 77.1% of the samples were of excellent quality. The most significant parameters affecting water quality were NO3−, F−, and Cr6+. The health risk assessment results showed that 27.1% and 54.2% of the samples lead to non-carcinogenic risks through oral intake for adults and children, respectively. In contrast, 12.5% of the groundwater samples would result in carcinogenic risks to the residents. This study showed that the WQI method needs to be supplemented by a health risk evaluation to obtain comprehensive results for groundwater quality protection and management in the Tongchuan area.
The Trend of Permeability of Loess in Yili, China, under Freeze–Thaw Cycles and Its Microscopic Mechanism
Authors: Lv Qianli , Zhang Zizhao , Zhang Tiandong , Hao Ruihua , Guo Zezhou , Huang Xuebang , Zhu Jianhua , Liu Tianchao
Published: November 2021

Loess landslides induced by the freeze–thaw effect frequently occur in Yili, China. Freeze–thaw cycles cause indelible changes in the soil microstructure, affecting its permeability. This study investigated the impacts of freeze–thaw cycles on the permeability of Yili loess using permeability tests on undisturbed (virgin, in situ) and remolded loess samples taken before and after freeze–thaw cycles. Scanning electron microscopy and nuclear magnetic resonance techniques were utilized to investigate the microscopic mechanism of the freeze–thaw process on the loess. Grey relation analysis (GRA) was employed to analyze the correlation between macroscopic permeability and microscopic parameters (maxi. radius, eccentricity, fractal dimension, directional probability entropy, and porosity). The results revealed that the permeability and all the microstructure parameters have roughly shown the same trend: “fluctuation–towards equilibrium–stability”. Firstly, the permeability coefficients of original and remolded loess experienced three and two peaked–trends, respectively, before 30 freeze–thaw cycles. The trends eventually stabilized within 30–60 freeze–thaw cycles. Increased number of freeze–thaw cycles disintegrated large particles in undisturbed loess into medium–sized particles, and particle shapes became more uncomplicated. Medium–sized particles in the remolded loess agglomerated to larger particles with more complex shapes. Furthermore, the overall porosity of the originally undisturbed loess decreased, and large and medium–sized pores transformed into small pores and micropores. In contrast, the overall porosity of remolded loess increased. Finally, the results revealed that permeability coefficients of the undisturbed and remolded loess became closely related with eccentricity and porosity, respectively. This study provides a reference for preventing and governing the loess landslides induced by the freeze–thaw cycles and permeability reduction in construction on loess in seasonally frozen areas in Yili.
Estimation of Heavy Metal Concentrations in the Water of Urban Lakes in the Russian Arctic (Murmansk)
Authors: Postevaya Marina A. , Slukovskii Zakhar I. , Dauvalter Vladimir A. , Bernadskaya Daria S.
Published: November 2021

This article presents the results of the analysis and estimation of the seasonal variation of heavy metals in the water of urban lakes and the assessment of their environmental state based on the chemical data. The research covered seven lakes in Murmansk, subject to various levels of anthropogenic load. Field studies were conducted in 2019–2020. Water samples were taken both in summer and in winter/spring seasons. The most polluted lake was Lake Ledovoe, where the highest concentrations of V, Cr, Co, Ni, Cu, W, and Mn were found. Lake Yuzhnoe, which is characterized by the lowest concentrations of studied heavy metals, was the least subject to anthropogenic load. In total, V, Ni, Zn, Fe, and Mn were above the background levels in the lakes of Murmansk. The analysis of the seasonal variation showed that the highest concentrations of heavy metals were found in winter/spring season and reached their maximum during the period of melt water intake from the catchment area. The research showed the impact of the urban environment on the chemical composition of the Murmansk lakes.
Integrated study of land use conditions in Nefteyugansk Khanty-Mansi autonomous okrug–Yugra
Authors: Rogatnev Y.M. , Shcherba V.N. , Komarova S.Yu. , Abramova O.S.
Published: November 2021

The article deals with the comprehensive study of the most valuable lands in Nefteyugansk. Determining the prospects for land use has long-term and significant implications for the quality of life. The high level of investment support for development leads to the need for accurate, comprehensive accounting not only of the state of lands, but especially the conditions of their functioning.
USO DEL JOB TO BE DONE COMO FUENTE DE DESARROLLO DE ESTRATEGIAS DE MARKETING DURANTE MOMENTOS DE CRISIS
Authors: García-Antonio Aniela , Beltrán-Sagundo Ahtziri Lucero , Luna-Jiménez Ana Laura
Published: November 2021

Comprender por qué el cliente adquiere un producto o servicio, tiene un nuevo protagonismo en el contexto de pandemia por COVID-19. La metodología Job to be Done propone detectar la razón por la que el consumidor contrata un producto o servicio, y de aquí emana la posibilidad de generar una solución efectiva para el cliente. Con este proyecto se busca detectar el trabajo que quiere hacer la persona que pide comida para llevar en la empresa familiar “Súper Tortas SagundoMR” ubicada en Tenosique, Tabasco; y de este modo construir estrategias enfocadas a dicho JTBD. Para ello, se realizó investigación cualitativa y cuantitativa con alcance transversal, a través de entrevistas y observación, así como el uso de la metodología Job Prioritization (Silverstein y De Carlo, 2012). Se encontró que esta empresa tiene potencial validado por sus consumidores en el servicio a domicilio y que sus razones para contratar este servicio se fincan en el sabor del producto. Existe potencial para reestablecer el servicio a domicilio utilizando el empuje que el valor de marca ha representado durante los últimos 30 años y de la validación del JTBD ganador.
LA VISIÓN ECOLÓGICA EMPRESARIAL EN LA RESPONSABILIDAD SOCIAL Y EN LA MERCADOTECNIA SUSTENTABLE DEL SECTOR TURISMO
Authors: Hernández-Ponce Oscar Ernesto , Saucedo-Monarque Javier , Borboa-Álvarez Edith Patrícia
Published: November 2021

El objetivo del presente estudio fue evaluar la visión ecológica empresarial de los prestadores de servicios turísticos conformada por la planeación ecológica empresarial y por la inversión en ecología; y su la relación con la responsabilidad social y con la mercadotecnia sustentable.

Se optó por le método cuantitativo no experimental con un análisis estadístico multivariante inferencial, utilizando el modelo de Regresión Lineal Múltiple para la aceptación o rechazo de las hipótesis de investigación. La muestra fue probabilística aleatoria, estratificada conformada por los prestadores de servicios turísticos del destino de Bahías de Huatulco, en Oaxaca y en el Municipio de Guaymas, Sonora en México.

Se concluye que al trabajar desde la lata dirección con una visión ecológica empresarial, se impactará positivamente en la Responsabilidad Social y en la mercadotecnia sustentable de los empresas prestadoras de servicios turísticos.
ESTUDIO MERCADOLÓGICO PARA LA REACTIVACIÓN DEL CENTRO ECOTURÍSTICO TZISCAO EN LA TRINITARIA, CHIAPAS
Authors: Yáñez-Domínguez Francisco Gabriel , Novelo-Galindo María Lucrecia , Guillén-Domínguez Yolanda Del Rosario
Published: November 2021

El turismo es un fenómeno muy complejo que involucra diversos aspectos tanto ecológicos, económicos, sociales y  culturales, así como diversos actores (turistas, pobladores, autoridades e instituciones) y donde por lo general poca atención se le ha prestado a los aspectos sociales y culturales de dicho fenómeno, es decir que en quienes se ha reparado poco es en los pobladores locales con su historia y sus condiciones sociales y culturales específicas, y quienes en última instancia son los que le dan concreción al planteamiento teórico. La necesidad de desarrollar el presente estudio mercadológico nace por la necesidad de aumentar la afluencia turística a los centros eco turísticos  del municipio de La Trinitaria ya que estos cuentan con una gran riqueza ambiental, para conocer mejor el potencial y generar estrategias de mercado se plantea una metodología descriptiva para identificar los factores clave de éxito de los centros, la cual fue apoyado por una colectada de información con trabajo de campo, realizando esto 4 de los principales centros eco turísticos del municipio señalado con la final de obtener resultados en la definición de estrategias que le ayudaran a que sean más competitivos y obtengas beneficios económicos provenientes del incremento de la demanda turística.
Fear effect in discrete prey-predator model incorporating square root functional response
Authors: Santra P.K.
Published: November 2021

In this work, an interaction between prey and its predator involving the effect of fear in presence of the predator and the square root functional response is investigated. Fixed points and their stability condition are calculated. The conditions for the occurrence of some phenomena namely Neimark-Sacker, Flip, and Fold bifurcations are given. Base on some hypothetical data, the numerical simulations consist of phase portraits and bifurcation diagrams are demonstrated to picturise the dynamical behavior. It is also shown numerically that rich dynamics are obtained by the discrete model as the effect of fear.
Computational dynamics of a Lotka-Volterra Model with additive Allee effect based on Atangana-Baleanu fractional derivative
Authors: Panigoro Hasan S. , Rahmi Emli
Published: November 2021

This paper studies an interaction between one prey and one predator following Lotka-Volterra model with additive Allee effect in predator. The Atangana-Baleanu fractional-order derivative is used for the operator. Since the theoretical ways to investigate the model using this operator are limited, the dynamical behaviors are identified numerically. By simulations, the influence of the order of the derivative on the dynamical behaviors is given. The numerical results show that the order of the derivative may impact the convergence rate, the occurrence of Hopf bifurcation, and the evolution of the diameter of the limit-cycle.
Ragam Kata Sapaan Kekerabatan Minangkabau di Keluarga Inti Berdasarkan Matrilineal pada Remaja Minang
Authors: Gusman Syifa Fadhilah , Arminda Fidela , Hafizah Wulan , Noveri Yana Tasya , Tuljannah Fauziyyah Wardah
Published: November 2021

Minangkabau is a regional language where it is used as the main language by indigenous people in Minangkabau. In minangkabau language the word greeting many undergo changes, especially the word greeting used by teenagers. In addition, the word greeting that already exists is not used anymore by teenagers today. The purpose of the research to be carried out by researchers is, as follows, to find out and describe what are the variety of greeting words used by Minang teenagers to their matrilineal nuclear family, to find out whether the use of greeting words in Minangkabau language begins to fade in Minang teenagers, to find out if minang teenagers still want to apply minangkabau language words in everyday life. The study involved 101 participants, which has been in accordance with the criteria of minang people, namely aged 15-24 years who are male and female. This criterion is prepared to obtain information related to the use of various words of matrilineal kinship in Minangkabau. Researchers used the open-ended-quotionnaire method. The analysis techniques in this study consist of open coding and selective coding. The results of the study can be concluded that, adolescent minang in using the word Minangkabau greeting based on matrilineal kinship undergoes many changes at this time. In addition, most of the subjects studied want to apply the word Minangkabau greeting in everyday life and in the future.
ПОЛІМОРФІЗМ ГЕНІВ COMT (VAL158MET), DRD2 (С32806Т), OPRM1 (А118G), NR3C1 (646C> G) ПРИ МІОФАСЦІАЛЬНОМУ БОЛЬОВОМУ СИНДРОМІ ОБЛИЧЧЯ
Authors: Гулюк С.А. , Вербицька Т.Г.
Published: November 2021

Актуальність. Біль у ділянці обличчя є однією з най- складніших проблем в сучасній медицині. Обумовлено це перш за все складністю структурно-функціональної організації ділянки обличчя, особливостями її іннерва- ції. Генетичні чинники грають важливу роль в інтен- сивності сприйняття болю. Мутації та однонуклео- тидний поліморфізм (SNP) в дезоксирибонуклеїнової кислоти (ДНК) можуть частково пояснити багато розходжень у чутливості до болю. Доведено зв’язок між болем і поліморфізмом генів, відповідальних за синтез нейромедіаторів, їх транспортерів і рецепто- рів (норадренергичних, серотонінових, дофамінових, опіоїдних), ферментів, метаболізуючих нейромедіа- тори. Вивчення патогенетичних механізмів розвитку больового синдрому обличчя і вдосконалення методів їх патогенетичної терапії, сьогодні є одним з карди- нальних напрямків у нейростоматологіі. Мета дослідження: вивчення поліморфізму генів COMT (Val158Met), DRD2 (С32806Т), NR3C1 (646C> G), OPRM1 (А118G) при міофасціальному больовому син- дромі обличчя. Матеріали та методи. Для молекулярно-генетич- ного аналізу використовували зразки ДНК генома 10 пацієнтів з діагнозом: міофасціальний больовий синдром обличчя. Виділення ДНК з клітин букального епітелію про- водили за модифікованою методикою з Chelex. Для виявлення однонуклеотидних замін локусів генів OPRM1, DRD2, NR3C1 використовували метод ПЛР- ПДРФ-аналізу, застосовуючи відповідні ендонуклеази рестрикції. Aлельні варіанти гена COMT (Val158Met) оцінювали методом алель специфічної полімеразної ланцюгової реакції (ПЛР). Ампліфікацію проводили на термоціклері «Labcycler» (SensQuest, Німеччина). Результати ампліфікації оцінювали шляхом прове- дення горизонтального електрофорезу в 2%-ному ага- розному гелі. Висновки. Результати генотипування пацієнтів з міо- фасціальним больовим синдромом обличчя показали, що 60% пацієнтів у досліджуваній групі, мають алель А в гомо- або гетерозиготній формі поліморфізму Val158Met, G472А гена COMT схильні до підвищеної чутливості до болю і сильнішою запальної реакції. Пацієнтам, які мають знижену щільність дофаміно- вих рецепторів D2 (наявність алелі А1) для зменшення хронічного болю і підвищення больового порогу необ- хідні препарати, що підвищують рівень дофаміну. Наявність мінорного G-алеля у 15% пацієнтів зумов- лює зниження ефективності наркотичних анальгети- ків за терапії больового синдрому. 25% пацієнтів, що несуть мінорний аллель G гена глюкокортикоїдного рецептора (NR3C1), потенційно можуть мати низь- кий рівень кортизолу, що необхідно враховувати при лікуванні опадами. Таким чином, дослідження генетичного поліморфізму пацієнтів з міофасціальним больовим синдромом обличчя показало можливості застосування геноти- пування для зниження факторів ризику формування хронічного міофасциального болю і своєчасної корек- тної терапії.
МЕЗЕНХІМАЛЬНІ СТОВБУРОВІ КЛІТИНИ ОДОНТОГЕННОГО ПОХОДЖЕННЯ: ПЕРСПЕКТИВИ ТА МОЖЛИВОСТІ РЕГЕНЕРАТИВНОЇ МЕДИЦИНИ
Authors: Годованець О.І. , Гальчук К.Л. , Муринюк Т.І. , Саука Е.О.
Published: November 2021

Мета: Провести аналіз літературних джерел у напрямку науково-теоретичних та клінічних аспек- тів щодо можливостей використання мезенхімаль- них стовбурових клітин, отриманих з різних джерел щелепно-лицевої ділянки. Матеріали і методи: Під час дослідження викорис- тано бібліосемантичний метод та структурно-логіч- ний аналіз. Для пошуку сучасної наукової літератури були використані електронні бази даних PubMed, MEDLINE, Scopus, Web of Science та EMBASE за клю- човими словами «regenerative medicine», «regenerative dentistry», «stem cells», «dental mesenchymal stem cells», «stem cell therapy», «tissue engineering». Висновки: На основі проведеного аналізу літера- тури прослідковується неабиякий інтерес науковців до стовбурових клітин одонтогенного походження та їх використання у регенеративній практиці не лише стоматологічного спрямування, але і для ліку- вання соматичних хвороб різного генезу. Це пов’язано із неінвазивним та більш простим методом забору матеріалу, порівняно із кістковим мозком людини чи ембріональними тканинами. Стовбурові клітини різ- няться за походженням, диференційною активністю та джерелом їх отримання, а також мають ваго- мий потенціал до диференціації за напрямком різних клітинних ліній залежно від впливу факторів росту та живильного середовища. При одержанні нових чистих культур вдається встановити їх походження шляхом ідентифікації експресії маркерів, характерних для стовбурових клітин. Тим не менш, незважаючи на високі очікування від подальшого розвитку реге- неративної терапії, науковцям необхідно детальніше вивчити можливості використання цих клітин на етапах клінічного випробування, дослідити імуноло- гічну поведінку стовбурових клітин одонтогенного походження в тому чи іншому середовищі.
EFFECTIVENESS ANALYSIS OF MONETARY TRANSMISSION
Authors: BOZKURT Hatice , MUTLU ÇAMOĞLU Seval
Published: November 2021

The Central Bank of the Republic of Turkey (CBRT)’s main target was price stability until the 2008 global crisis, it also focused on financial stability in the post-crisis period. CBRT has implemented new monetary policies that would react against shocks apart from traditional practices to limit the negative effects of the crisis since the end of 2010. The aim of this study is to analyze the effectiveness of the transmission channels of the monetary policies implemented by CBRT, comparing the traditional and new monetary policy periods. In this study, the effectiveness of the change in the monetary policy of the central bank in achieving the stability goals through credit and exchange rate transfer channels was compared as of 2002-2011 and 2011-2020 periods. The structural VAR (SVAR) model was used in the analysis since it allows the structural changes of variables based on economic theory. According to the findings, the effect of credit and exchange rate channels on inflation in 2002-2011 is compatible with the expectations. It was found that interest rate is the most important determinant of the fluctuations in credits and exchange rates. In 2011-2020, the effect of the transmission mechanism of credit and exchange rate channels over interest rates on inflation is compatible with the expectations. The majority of the variations in credits and exchange rates originated from the interest rates. Most of the fluctuations in inflation are caused by exchange rate and credit fluctuations, and the explanatory power of the exchange rate is relatively high.
FACTORS INFLUENCING NEW GRADUATES’ START-UP INTENTIONS IN ENGINEERING TECHNOLOGY IN CAN THO CITY
Authors: Huynh Lam Canh Thanh , Nguyen Tan Minh , Huynh Nha Thanh
Published: November 2021

This study aims to find what factors influence new graduates’ start-up intentions in the field of Engineering Technology in the city of Can Tho. Surveys were completed by 400 new graduates from universities in the area with Cronbach’s Alpha test method, exploratory factor analysis, and multiple linear regression were utilized in order to examine the relationships among the factors and the new graduates’ start-up intentions. The results showed that factors influencing new graduates’ start-up intentions comprise of attitudes, external factors and subjective thinking.
CHANGES IN RELIGIOUS ACTIVITIES OF SOUTHERN KHMER THERAVADA BUDDHISTS IN SOC TRANG PROVINCE, VIET NAM, FROM 1986 TO 2015
Authors: Pham Khanh Tiet , Lam Ly Minh
Published: November 2021

The study aims to identify the changes in religious activities of Southern Khmer Theravada Buddhists in Soc Trang Province in the period of 1986 to 2015. The methods of interview and questionnaire were used to collectprimary data in the study. Research results found that there are many changes in the religious activities of Southern Khmer Theravada Buddhists in Soc Trang Province from 1986 to 2015. Occu pational structure, age group, number of monks, dignitaries, activities of monks are the changes identified from the findings. These changes reflect the change in the concept of Southern Khmer Theravada Buddhists, the change in socioeconomic conditions in Soc Trang Province in the period of 1986 to 2015.
Stakeholder Perspectives on Improving Educational Outcomes in Enugu State
Authors: Ogwuike Clinton Obinna , Iheonu Chimere
Published: November 2021

Education remains crucial for socioeconomic development and is linked to improved quality of life. In Nigeria, basic education has remained poor and is characterised by unhealthy attributes, including low quality infrastructure and a lack of effective management of primary and secondary schools. Access to education is a massive issue—according to the United Nations, there are currently about 10.5 million out of school children in Nigeria, and 1 in every 5 of the world’s out-of-school-children lives in Nigeria despite the fact that primary education in Nigeria is free. A considerable divide exists between the northern and southern regions of Nigeria, with the southern region performing better across most education metrics. That said, many children in southern Nigeria also do not go to school. In Nigeria’s South West Zone, 2016 data from the Nigerian Federal Ministry of Education reveals that Lagos State has the highest number of out of school children with more than 560,000 children aged 6-11 not going to school. In the South South Zone, Rivers State has the highest number of out-of-school children; more than 900,000 children aged 6-11 are not able to access education in this state. In Enugu State in the South East Zone, there are more than 340,000 children who do not have access to schooling (2016 is the most recent year high-quality data is available—these numbers have likely increased due to the impacts of COVID-19). As part of its political economy research project, the RISE Nigeria team conducted surveys of education stakeholders in Enugu State including teachers, parents, school administrators, youth leaders, religious leaders, and others in December 2020. The team also visited 10 schools in Nkanu West Local Government Area (LGA), Nsukka LGA, and Udi LGA to speak to administrators and teachers, and assess conditions. It then held three RISE Education Summits, in which RISE team members facilitated dialogues between stakeholders and political leaders about improving education policies and outcomes in Enugu. These types of interactions are rare in Nigeria and have the potential to impact the education sector by increasing local demand for quality education and government accountability in providing it. Inputs from the surveys in the LGAs determined the education sector issues included in the agenda for the meeting, which political leaders were able to see in advance. The Summits culminated with the presentation of a social contract, which the team hopes will aid stakeholders in the education sector in monitoring the government’s progress on education priorities. This article draws on stakeholder surveys and conversations, insights from the Education Summits, school visits, and secondary data to provide an overview of educational challenges in Enugu State with a focus on basic education. It then seeks to highlight potential solutions to these problems based on local stakeholders’ insights from the surveys and the outcomes of the Education Summits.
Educación hospitalaria: una aproximación al pensamiento filosófico de la hospitalidad desde la experiencia docente
Authors:   , Argumedo Malvina
Published: November 2021

Enmarcada en el campo de las Ciencias de la Educación esta tesis propone un acercamiento filosófico a la noción de hospitalidad en clave educativa y a los posibles sentidos construidos, otorgados y recreados en torno a ella a partir de un análisis cualitativo de relatos de experiencias docentes en el marco del formato escolar de las Escuelas Hospitalarias de la Ciudad de Buenos Aires y Ciudad de Mendoza. ¿Qué hay de hospitalario en las escuelas hospitalarias? ¿Puede la hospitalidad ser una disposición ética y política que dé cuerpo a las propuestas educativas escolares? Este trabajo permite abrir espacios de pensamiento y conversación respecto de las posibilidades que tienen las escuelas hospitalarias en particular y la educación en general, de ofrecer propuestas que reciban hospitalariamente a las infancias a partir del reconocimiento de la existencia de otras temporalidades y otras corporalidades que desafían las lógicas disciplinadoras-normalizadoras de la biomedicina y la pedagogía, revalorizando la tarea de construcción de saberes pedagógicos que los docentes crean y recrean con lenguajes, prácticas y poéticas originales frente a la situación de enfermedad que transitan sus alumnos.
Pemodelan Matematika SEIR Penyebaran Penyakit Pneumonia pada Balita dengan Pengaruh Vaksinasi di Kota Makassar
Authors: Side Syafruddin , Sanusi Wahidah , Bohari Nurul Aulia
Published: November 2021

Abstrak. Penelitian ini bertujuan untuk membangun model penyebaran penyakit pneumonia pada balita tipe SEIR (Susceptible- Exposed- Infected- Recovered-), menganalisis model, dan menentukan proporsi minimum vaksinasi. Data yang digunakan adalah data jumlah penderita pneumonia pada balita di Kota Makassar tahun 2019. Hasil penelitian diperoleh model matematika SEIR penyakit pneumonia dalam bentuk sistem persamaan diferensial biasa; titik keseimbangan bebas kecanduan dan titik keseimbangan kecanduan yang keduanya bersifat stabil; bilangan reproduksi dasar untuk simulasi tanpa vaksinasi lebih besar dari 1 yang artinya penyakit masih tetap ada dalam populasi, sedangkan bilangan reproduksi dasar untuk simulasi dengan vasksinasi kurang dari 1 yang artinya penyakit akan menghilang dan tidak meluas dari populasi.Kata Kunci: Titik Ekuilibrium, Bilangan Reproduksi Dasar, Pneumonia, Model SEIR.Abstract.This study aims to build a model of the spread of pneumonia in SEIR (Susceptible-Exposed-Infected-Recovered) toddlers, analyze the model, and determine the minimum proportion of vaccinations. The data used are data on the number of pneumonia sufferers in toddlers in Makassar City in 2019.The results obtained by the SEIR mathematical model of pneumonia in the form of ordinary differential equation systems; addiction free balance points and addiction balance points which are both stable; basic reproduction numbers for simulations without vaccination greater than 1, which means that the disease still exists in the population, while basic reproduction numbers for simulations with vasksination less than 1, which means the disease will disappear and not spread from the population.Keywords: Equilibrium Points, Basic Reproductive Numbers, Pneumonia, SEIR Model.
МУЗИЧНЕ МИСТЕЦТВО ЯК ЗАСІБ ФОРМУВАННЯ МОРАЛЬНО-ДУХОВНИХ ЦІННОСТЕЙ МОЛОДШИХ ШКОЛЯРІВ
Authors: Потапчук Тетяна , Клепар Марія , Фабрика-Процька Ольга
Published: November 2021

Визначення статусу мистецтва, зокрема, музичнoго, та рoзуміння діяльнісної перспективи впливу музики на мoральність та духoвність учня, допоможе розв’язати основне питання музично-педагогічної освіти, постулатом якої стає становлення особистості (інтелектуальне та художнє) як pезультат її самopoзвитку і poзвитку її твopчих пoтенцій, що забезпечить всебічну підгoтoвку молодшого шкoляpа.

Відомо, що музичне мистецтво має властивість не лише формувати емоційний досвід, але й просвітлювати, очищати людські переживання. Цей очищувальний вплив - катарсис - є доказом зв’язку музичної творчості з вищими людськими цінностями.

Музичне мистецтво перш за все мистецтво емоцій, проте це мистецтво здатне впливати на інтелектуальну сферу особистості, збагачуючи її знання про морально-духовні цінності. В цьому випадку музичний твір є джерелом інформації про художній світогляд певного періоду, напряму, національної школи митця.

Впливаючи на людину насамперед через переживання, музичне мистецтво володіє унікальною здатністю активізувати емоційну сприйнятливість, збагачувати досвід почувань, а, отже, всебічно розвивати особистість, її ціннісні установки, загальну культуру.

Завдяки морально-духовним цінностям, музичне мистецтво, особливо духовна музика, дає людині можливість пережити чуже життя як своє, збагатитися досвідом багатьох поколінь, зробити його фактом свого буття. Мистецтво спонукає до співпереживання (емпатії), співчуття, здатності зрозуміти емоційний стан іншої людини (синтонії), сприяє формуванню людських відносин, зокрема й морально-духовних цінностей.

Із усіх мистецтв, музика найбільш яскраво виражає сутність внутрішнього, особистісного життя людини, а значить і життя взагалі, оскільки самоспостереження є взагалі єдиним джерелом пізнання глибин буття.
ІННОВАЦІЙНО-ГУМАНІСТИЧНА ПЕДАГОГІКА В.СУХОМЛИНСЬКОГО І РОЗБУДОВА НОВОЇ УКРАЇНСЬКОЇ ПОЧАТКОВОЇ ШКОЛИ
Authors: Островська Маріанна
Published: November 2021

У статті розглядаються концептуальні педагогічні ідеї Василя Сухомлинського і актуальні проблеми підготовки вчителів початкових класів до реалізації основних завдань Концепції «Нова українська школа», у контексті Державного стандарту початкової освіти та нового Професійного стандарту вчителя. Показано, що підготовка компетентного вчителя і його ефективна інноваційно-гуманістична освітня діяльність у школі є одним з провідних завдань реформування освіти в Україні. Наголошується, що у процесі реформування освітньої системи, підготовки вчителя нової початкової школи, в освітній діяльності закладів вищої освіти педагогічного спрямування, доречно використовувати новаторську педагогічну спадщину В.Сухомлинського, насамперед його ідеї щодо покращення ефективності навчання, виховання і особистісного розвитку учнів та організації освітнього процесу в сучасній школі. Сучасна реформа освіти у рамках Концепції «Нова українська школа» та прийнятих інституційних документів на її виконання, сприяють більш широкому використанню гуманістичних педагогічних ідей визнаного українського вченого В.Сухомлинського як складових сучасного інноваційного освітнього процесу, який проводять заклади вищої освіти здійснюючи підготовку майбутніх учителів початкової школи.