bluuebunny/crossref_metadata_2025 huggingface dataset:
Cooperative navigation of unmanned aerial vehicle swarm based on cooperative dilution of precision
Authors: Chen Mingxing , Xiong Zhi , Liu Jianye , Wang Rong , Xiong Jun
Published: June 2020

Aiming at the formation problem in the cooperative navigation of unmanned aerial vehicle swarm, a cooperative position error analysis method based on cooperative dilution of precision is studied in this article. During cooperative flight, the unmanned aerial vehicle swarm can use the received position and ranging information of the adjacent unmanned aerial vehicles to calculate the position, and fuse with its own sensor position information. The final positioning accuracy depends not only on the capability of the ranging sensor but also on the position accuracy and formation of the adjacent unmanned aerial vehicles. In this article, these influence factors are combined to put forward a cooperative dilution of precision calculation method suitable for unmanned aerial vehicle swarm cooperative navigation. On this basis, a cooperative integrated navigation method based on ranging information is designed. Finally, the performance of cooperative navigation of unmanned aerial vehicles in different formations is simulated and analyzed. The simulation result shows that the cooperative dilution of precision method proposed in this article can effectively analyze the influence of formation on the positioning accuracy of unmanned aerial vehicle swarm, and the final combined positioning result is consistent with the cooperative dilution of precision analysis result.
Habitual Behavior Is Goal-Driven
Authors: Kruglanski Arie W. , Szumowska Ewa
Published: June 2020

We address the relation between goal-driven and habitual behaviors. Whereas in recent years the two have been juxtaposed, we suggest that habitual behavior is in fact goal-driven. To support this view, we show that habitual behavior is sensitive to changes in goal properties (reward contingencies), namely goal value and its expectancy of attainment. Whereas adjustment to these properties may be slower for habitual (or overlearned) than for nonhabitual behavior, this is likely due to the routinized (or automatic) nature of such behavior, characterized as it is by reduced attention to its consequences. Furthermore, we show that habitual behavior’s prolonged persistence despite its manifest detachment from the original goal likely stems from its attachment to a different goal. Thus, there is no need to postulate purposeless behavior. The view that habitual behavior is goal-driven offers an integrative account of a considerable body of evidence and is consistent with a functional account of psychological processes.
Analysis of minimal path and cut vectors in multistate monotone systems and use it for detection of binary type multistate monotone systems
Authors: Kozyra Paweł Marcin
Published: June 2020

Theorem specifying how all minimal cut (path) vectors to level j can be obtained from all minimal path (cut) vectors to level j in any multistate monotone system is proven. Characterizations of binary type multistate monotone systems and binary type multistate strongly coherent systems by minimal cut and path vectors and corresponding to them, binary type cut and path sets are also demonstrated.
Meniscal Root Tears and Extrusion Are Significantly Associated with the Development of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Authors: Foreman Sarah C. , Liu Yao , Nevitt Michael C. , Neumann Jan , Joseph Gabby B. , Lane Nancy E. , McCulloch Charles E. , Link Thomas M.
Published: June 2020

Objective

To identify joint structural risk factors, measured using quantitative compositional and semiquantitative magnetic resonance imaging (MRI) scoring, associated with the development of accelerated knee osteoarthritis (AKOA) compared with a more normal rate of knee osteoarthritis (OA) development.

Design

From the Osteoarthritis Initiative we selected knees with no radiographic OA (Kellgren-Lawrence grade [KL] 0/1) that developed advanced-stage OA (KL 3/4; AKOA) within a 4-year timeframe and a comparison group with a more normal rate of OA development (KL 0/1 to KL 2 in 4 years). MRIs at the beginning of the 4-year timeframe were assessed for cartilage T2 values and structural abnormalities using a modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). Associations of MRI findings with AKOA versus normal OA were assessed using multivariable logistic regression models.

Results

A total of 106 AKOA and 168 subjects with normal OA development were included. Mean cartilage T2 values were not significantly associated with AKOA (odds ratio [OR] 1.06; 95% confidence interval [CI] 0.82-1.36). Risk factors for AKOA development included higher meniscus maximum scores (OR 1.37; 95% CI 1.11-1.68), presence of meniscal extrusion (OR 6.30; 95% CI 2.57-15.49), presence of root tears (OR 4.64; 95% CI 1.61-13.34), and higher medial tibia cartilage lesion scores (OR 1.96; 95% CI 1.19-3.24).

Conclusions

We identified meniscal damage, especially meniscal extrusion and meniscal root tears as risk factors for AKOA development. These findings contribute to identifying subjects at risk of AKOA at an early stage when preventative measures targeting modifiable risk factors such as meniscal repair surgery could still be effective.
Optimization and Validation of a Human Ex Vivo Femoral Head Model for Preclinical Cartilage Research and Regenerative Therapies
Authors: Styczynska-Soczka Katarzyna , Amin Anish K. , Simpson A. Hamish W. , Hall Andrew C.
Published: June 2020

Objective

Articular cartilage is incapable of effective repair following injury or during osteoarthritis. While there have been developments in cartilage repair technologies, there is a need to advance biologically relevant models for preclinical testing of biomaterial and regenerative therapies. This study describes conditions for the effective ex vivo culture of the whole human femoral head.

Design

Fresh, viable femoral heads were obtained from femoral neck fractures and cultured for up to 10 weeks in (a) Dulbecco’s modified Eagle’s medium (DMEM); (b) DMEM + mixing; (c) DMEM + 10% human serum (HS); (d) DMEM + 10% HS + mixing. The viability, morphology, volume, and density of fluorescently labelled in situ chondrocytes and cartilage surface roughness were assessed by confocal microscopy. Cartilage histology was studied for glycosaminoglycan content using Alcian blue and collagen content using picrosirius red.

Results

Chondrocyte viability remained at >95% in DMEM + 10% HS. In DMEM alone, viability remained high for ~4 weeks and then declined. For the other conditions, superficial zone chondrocyte viability fell to <35% at 10 weeks with deeper zones being relatively unaffected. In DMEM + 10% HS at 10 weeks, the number of chondrocytes possessing cytoplasmic processes increased compared with DMEM ( P = 0.017). Alcian blue labeling decreased ( P = 0.02) and cartilage thinned ( P ≤ 0.05); however, there was no change to surface roughness, chondrocyte density, chondrocyte volume, or picrosirius red labeling ( P > 0.05).

Conclusions

In this ex vivo model, chondrocyte viability was maintained in human femoral heads for up to 10 weeks in culture, a novel finding not previously reported. This human model could prove invaluable for the exploration, development, and assessment of preclinical cartilage repair and regenerative therapies.
Academic Performance: The Role of Grit Compared to Short and Comprehensive Inventories of Conscientiousness
Authors: Hagen Fredrik Stølan , Solem Stian
Published: June 2020

Grit has been suggested as a predictor of academic success over and above established constructs like conscientiousness (C) but has only been compared to brief inventories of trait-level C. This study examined the difference between using a brief inventory of C (Big Five Inventory [BFI]) and a facet-level inventory (NEO Personality Inventory–Revised [NEO PI-R]) as controls for grit in an undergraduate sample ( N = 1,394). Grit exhibited strong correlations with C, particularly the facets of self-discipline and achievement striving. When BFI was used, both grit and C added small increments in explained variance while controlling for each other. When NEO PI-R was used, grit could not explain any additional variance in university grade and minuscule amounts (4%) in high school grade. Facets of C added moderate amounts (16%–54%) of incremental variance to both university and high school grades when controlling for grit. The results demonstrated that different outcomes are to be expected depending upon the choice of C measure.
Comparison of temperature readings using infrared thermometers at three different sites: tympanic, forehead and temporal
Authors: Fong Warren Weng Seng , Yeo Shuan Khiag , Fook-Chong Stephanie Man Chung , Phang Jie Kie , Sim Eugene
Published: June 2020

The aim of this study was to compare the body temperature measurements at tympanic, forehead and temporal sites using infrared thermometers. A total of 1576 consecutive visitors to Singapore General Hospital at two entry locations were included in this study. Pearson correlation and Bland–Altman mean difference between sites (95% confidence interval for limits of agreement) were calculated for the relationship between the three different sites of temperatures recorded (i.e. temporal, forehead and tympanic). Of all the visitors, 27 (1.7%) had fever. Moderate positive correlation was found between temporal and forehead temperature readings ( r=0.602, mean difference (temporal – forehead), (95% limits of agreement) = 0.1 (−0.8, 0.7)), and there was very weak positive correlation between tympanic and temporal temperature readings ( r=0.177, mean difference (temporal – tympanic), (95% limits of agreement) = −0.3 (−1.7, 1.1)). Sensitivity for temporal temperature readings (⩾37.5°C) to detect febrile visitors was 3.7%, specificity was 99.6%, positive predictive value was 14.3% and negative predictive value was 98.3%. Our results demonstrate that tympanic temperature readings should be used for fever screening instead of temporal or forehead readings.
Adult obesity complications: challenges and clinical impact
Authors: Ansari Saleem , Haboubi Hasan , Haboubi Nadim
Published: June 2020

The complications associated with adult obesity are overwhelming national healthcare systems. No country has yet implemented a successful population-level strategy to reverse the rising trends of obesity. This article presents epidemiological data on the complications of adult obesity and discusses some of the challenges associated with managing this disease at a population and individual level.
Structural inequality in the time of COVID-19: Urbanization, segregation, and pandemic control in sub-Saharan Africa
Authors: Finn Brandon M , Kobayashi Lindsay C
Published: June 2020

The COVID-19 pandemic exposes countries and people in sub-Saharan Africa to severe risks because of structural global inequalities. There is a simultaneous risk of the use of public health action to enact oppressive governance policies, which is happening in response to COVID-19 in many countries. In this commentary, we use the example of 20th-century pandemic control in pre-apartheid South Africa to illustrate how public health crises can engender oppressive social, economic, and spatial transformations.
Intersectional geographies and COVID-19
Authors: Eaves LaToya , Al-Hindi Karen Falconer
Published: June 2020

We argue that it is time for geography as a discipline to embrace intersectionality. Using the COVID-19 pandemic as the subject of analysis, we raise questions for geographers about the novel coronavirus’ overlapping impacts. We argue that intersectional feminist approaches yield anti-racist, anti-sexist, and anti-oppressive research outcomes.
The annihilation of time by space in the COVID-19 pandemic downturn
Authors: Ward Callum
Published: June 2020

A defining feature of capitalism has been its ‘annihilation of space by time’ in the constant reduction of geographical barriers to rapid exchange. Overviewing how the COVID-19 pandemic lockdown has triggered a financial crisis staunched only by massive government bailouts, this commentary points to a need to orient analysis to the annihilation of time by space.
Shareable and un-sharable knowledge
Authors: Andrejevic Mark
Published: June 2020

This article focuses on what it means to generate actionable but non-sharable information, and how this might relate to our understanding of what counts as knowledge, which typically entails some form of explanation. As automated systems sort and classify us for the purposes of dating, education, employment, health care, security, and more, we are going to want to know how and why these decisions are being made. Or, failing that, we will at least want to know, with as much clarity as possible, under what circumstances and to what uses, automated systems are being put to use. In either case, the role of narrative is inseparable from the call for transparency.
Impact of nickel oral hyposensitization on quality of life in systemic nickel allergy syndrome
Authors: Rizzi Angela , Di Rienzo Alessia , Buonomo Alessandro , Aruanno Arianna , Carusi Valentina , Ricci Anna Giulia , Centrone Michele , Mezzacappa Simona , Romeo Lilli , Schiavino Domenico , Inchingolo Riccardo , Gasbarrini Antonio , Nucera Eleonora
Published: June 2020

Nickel (Ni) oral hyposensitization treatment (NiOHT) is an effective management approach for Ni allergy. No health-related quality of life (HRQoL) data exist for the pre- and post-treatment with NiOHT in systemic nickel allergy syndrome (SNAS). The aims of this study were (a) to explore HRQoL in SNAS patients, (b) to assess changes of HRQoL after 1 year of NiOHT; (c) to evaluate psychological status of patients. SNAS patients completed the Short-Form 36-Item Health Survey and Psychological General Well-Being Index before and 1 week after the end of NiOHT. Moreover, psychological state was assessed with the Minnesota Multiphasic Personality Inventory (MMPI-2). A total of 52 patients self-reported pre- and post-treatment questionnaires. HRQoL was poor at baseline. After 1 year of NiOHT, all outcome measure scores improved by about 20% with respect to baseline data ( P < 0.01 for all indices, except depressed mood). Finally, 33 patients performed the MMPI-2. High rates for hypochondriasis and depression were noted. Furthermore, most of the patients had high scores for anxiety, depression, and health concerns. This is the first study showing that NiOHT improves HRQoL of SNAS patients, which can be considered a “personalized medicine” approach.
Necessary connections: ‘Feelings photographs’ in criminal justice research
Authors: Rogers Chrissie
Published: June 2020

Visual representations of prisons and their inmates are common in the news and social media, with stories about riots, squalor, drugs, self-harm and suicide hitting the headlines. Prisoners’ families are left to worry about the implications of such events on their kin, while those incarcerated and less able to understand social cues, norms and rules, are vulnerable to deteriorating mental health at best, to death at worst. As part of the life-story method in my research with offenders who are on the autism spectrum, have mental health problems and/or have learning difficulties, and prisoner’s mothers, I asked participants to take photographs, reflecting upon their experiences. Photographs, in this case, were primarily used to help respondents consider and articulate their feelings in follow-up interviews. Notably, seeing (and imagining) is often how we make a connection to something (object or feeling), or someone (relationships), such that images in fiction, news/social media, drama, art, film and photographs can shape the way people think and behave – indeed feel about things and people. Images and representations ought to be taken seriously in researching social life, as how we interpret photographs, paintings, stories and television shows is based on our own imaginings, biography, culture and history. Therefore, we look at and process an image before words escape, by ‘seeing’ and imagining. How my participants and I ‘collaborate’ in doing visual methods and then how we make meaning of the photographs in storying their feelings, is insightful. As it is, I wanted to enable my participants to make and create their own stories via their photographs and narratives, while connecting to them, along with my own interpretation and subjectivities.
Mathematical, Mathematics Educational, and Educational Values in Mathematical Modeling Tasks
Authors: Dede Yüksel , Akçakın Veysel , Kaya Gürcan
Published: June 2020

Purpose:

The purpose of this study is to explore the mathematical values, mathematics educational values, and educational values involved in mathematical modeling tasks based on different mathematical modeling perspectives.

Design/Approach/Methods:

In this context, the present study is a qualitative research based on document analysis. The data were analyzed using semantic content analysis, and the selected modeling tasks based on different mathematical modeling perspectives were examined at the sentence level.

Findings:

Control, mystery, and openness mathematical values appeared in all mathematical modeling tasks, and rationalism and objectivism mathematical values appeared in realistic/applied and socio-critical modeling perspectives. Product, exploration, creating, relevance, pleasure, and application mathematics educational values also emerged in all modeling tasks. Educational values of social justice, equity, social welfare, humanity, and altruism were more important in the socio-critical modeling, while the value of individualism was more emphasized in the model-eliciting approach.

Originality/Value:

By determining mathematical, mathematics educational, and educational values involved in mathematical modeling tasks based on different mathematical modeling perspectives, an effective and more value-balanced mathematical modeling instruction can be provided.
Expedited Desensitization to Canakinumab
Authors: Sanan Neha , Schend Jason , Rowane Marija , Hostoffer Robert
Published: June 2020

Introduction

Interleukin-1 (IL-1) antagonists have been successful in the management of monogenic auto-inflammatory diseases, notably classic hereditary fever syndromes, such as Familial Mediterranean Fever (FMF). Anakinra (Kineret®), a human recombinant IL-1 receptor antagonist (IL-1Ra), has been clinically effective in the management of persistent auto-inflammation, such as FMF. Few studies report anaphylaxis in response to anakinra, which were resolved with an anakinra desensitization or the anti-IL-1β monoclonal antibody canakinumab (ILARIS®). We describe the first reported desensitization protocol to canakinumab.

Case Report

A 51-year-old man with a prior history of FMF presented with history of failed colchicine, nonsteroidal anti-inflammatory drug, and anakinra trials. Anakinra desensitization and canakinumab intradermal testing (IDT) resulted in anaphylactic and allergic symptoms, respectively. Expedited desensitization to canakinumab was successfully performed with 15-minute intervals between 13 doses of incremental increase to 150 mg.

Discussion

Biological agents are immune modulators that may evoke unanticipated hypersensitivity reactions, including anaphylaxis. These anaphylactic reactions to biologics have been infrequently reported, but the expanding market may increase the risk of IgE-mediated hypersensitivities and subsequent need for desensitization protocols. The current, expedited desensitization evaluated several published protocols involving anakinra desensitization to determine appropriate dosing for canakinumab.

Conclusion

We report the gastrointestinal intolerance and continued FMF flares on colchicine, followed by anaphylactic responses to anakinra and allergic reaction to IDT of canakinumab, in the present case of FMF. Our novel, expedited canakinumab desensitization protocol serves as an effective and alternative therapy in cases when other appropriate biologic agents are not tolerated.
Does Local Administration of Liposomal Bupivacaine Reduce Pain and Narcotic Consumption in Adult Spinal Deformity Surgery?
Authors: Chung Andrew S. , Crandall Dennis , Revella Jan , Adeniyi Biodun , Chang Yu Hui H. , Chang Michael S.
Published: June 2020

Study Design:

Retrospective cohort study.

Objective:

To determine if local administration of liposomal bupivacaine (LB) reduces postoperative pain scores and narcotic use in spinal deformity patients.

Methods:

Adult patients undergoing elective spinal fusion (7 or more levels) for scoliosis or kyphosis were selected for inclusion. Patients received either periincisional injections of combined liposomal and standard bupivacaine (n = 90, group L) or standard bupivacaine only (n = 69, group C). Perioperative pain scores (VAS [visual analogue scale]), opioid use, length of stay, functional outcome (ODI [Oswestry Disability Index]), and perioperative complications were recorded. No external funding was received for this study.

Results:

A total of 159 patients met inclusion criteria (mean age was 54.2 years of age). No significant baseline demographic differences were noted between the 2 groups. Group L experienced slight improvements in pain control on postoperative day (POD) 1 ( P = .02). No difference in pain scores were otherwise noted. Group L transitioned off of intravenous (IV) narcotics faster with 52.6% less IV use by POD3 ( P = .03). No differences in total narcotic consumption, perioperative complications, lengths of stay, and functional outcome scores were otherwise noted between the 2 cohorts.

Conclusions:

The use of LB in adult spinal deformity surgery does not appear to provide clinically important improvements in postoperative pain at the manufacturer’s recommended dosage. Furthermore, while patients receiving LB may transition more quickly off of IV narcotics, this does not appear to translate into an overall decrease in narcotic consumption, hasten return of bowel function, or decrease hospital lengths of stay. Future prospective randomized control trials are warranted. The use of varying dosages of LB may also help further clarify the true efficacy of LB in the setting of spinal deformity surgery.
Comparison of peripheral nerve block with local infiltration analgesia regarding walking ability after total knee replacement: A retrospective, propensity-score matched-pair cohort study
Authors: Fukuda Taeko , Imai Shinobu , Simoda Shunji , Nakdera Masaya , Horiguchi Hiromasa
Published: June 2020

Purpose:

It is unclear whether perioperative analgesic techniques affect the functional outcome of total knee replacement (TKR). We investigated the effects of peripheral nerve block (PNB) and local infiltration (LI) on walking ability after TKR.

Methods:

The medical records of 7143 patients who underwent TKR using general anesthesia with PNB or LI techniques were reviewed. Factors affecting independence and/or improvement of walking after surgery were investigated using multivariate regression analysis. To adjust for baseline differences and minimize selection bias for the chosen analgesic technique, patients were matched by propensity scores.

Results:

The multivariate regression analysis showed that PNB was associated with independence and/or improvement of walking. Of the 7143 patients, 2755 (39%) received PNB analgesia and 4388 (61%) LI analgesia. After the propensity score matching, the analgesic types were not associated with walking ability. Independence reflected by the total score of daily living activities was higher in the PNB group than in the LI group. The PNB group started rehabilitation later but performed rehabilitation for longer in the initial period than the LI group. Consumption levels of fentanyl, pentazocine, and antiemetics were lower in the PNB group than in the LI group. The PNB group had fewer hypertensive episodes during surgery than the LI group. There was no significant difference in total hospitalization costs between the two groups.

Conclusions:

No significant difference in postoperative walking ability was found between PNB and LI groups. However, PNB offered some advantages over LI. Future detailed investigations to improve TKR surgery are needed.
Acute Effects of Increased Joint Mobilization Treatment Duration on Ankle Function and Dynamic Postural Control in Female Athletes With Chronic Ankle Instability
Authors: Holland Christopher J. , Hughes Jonathan D. , De Ste Croix Mark B.A.
Published: June 2020

Background:

Chronic ankle instability (CAI) is linked to mechanical and functional insufficiencies. Joint mobilization is purported to be effective at treating these deficits.

Purpose:

To examine the effect of different treatment durations of a grade IV anterior-to-posterior ankle joint mobilization on weightbearing dorsiflexion range of motion (WB-DFROM), posterior talar glide (PG), and dynamic postural control in individuals with CAI.

Study Design:

Controlled laboratory study.

Methods:

A total of 48 female athletes (mean age, 22.8 ± 4.8 years) with unilateral CAI participated in this study. Participants were randomly assigned to 1 of 3 treatment conditions: 30 seconds, 60 seconds, and 120 seconds. Treatment was provided to the injured limb on 3 separate occasions 48 hours apart and consisted of a Maitland grade IV anterior-to-posterior talar joint mobilization based on the participant’s initial group assignment. WB-DFROM; PG; and the anterior (ANT), posteromedial (PM), and posterolateral (PL) reach directions of the Star Excursion Balance Test were measured bilaterally before and after each treatment. The uninjured limb acted as a control. Data were analyzed using 2-way mixed-model analyses of variance, and effect sizes were calculated through use of Hedges g.

Results:

Significant differences were detected after all treatment sessions for all outcome measures ( P ≤ .001) and between treatment groups after sessions 1, 2, and 3 for all outcome measures ( P ≤ .001). Effect sizes were very large or huge for all treatment groups for WB-DFROM, PG, and ANT reach direction. Substantial variation was found in effect sizes for PM and PL measures.

Conclusion:

Accessory mobilization is an effective treatment to induce acute changes in ankle motion and dynamic postural control in patients with CAI, with longer treatment durations conferring greater improvements.

Clinical Relevance:

This study adds clarity to the use of joint mobilization treatments and will add to the current clinical practice strategy for patients with CAI.
Reforming Undergraduate Psychiatry Training in Ukraine
Authors: Kopchak Oksana , Pinchuk Irina , Ivnev Boris , Skokauskas Norbert
Published: June 2020

In Ukraine, mental health problems are common yet the mental health services available are still old fashioned and based on healthcare approaches used in the Soviet Union, providing mainly inpatient services and rudimentary community services. The World Health Organization (WHO) introduced the Mental Health Gap Action Programme (mhGAP) to reduce the mental health treatment gap all over the world and 2 years later introduced the WHO mhGAP-Intervention Guide (mhGAP-IG), version 2.0 (2016) as not only an educational tool, but also an evidence based guideline to scale up services for mental, neurological and substance use (MNS) conditions with an objective to reduce gap between available health systems capacity and resources for mental health. The main aim of this paper is to describe reforms of undergraduate psychiatry training in Ukraine using Kyiv Medical University as a case example. Kyiv Medical University (KMU) is the first university in Ukraine to introduce the mhGAP-IG in Ukraine. The revised psychiatry curricula in KMU aims to strengthens the evidence based teaching practices, to put emphasis on community orientated mental health care, and to use interactive teaching methods that the university hopes will attract more future doctors to psychiatry and ideally contribute towards the reduction of the mental health treatment-gap in Ukraine.
An Exploration of Knowledge and Attitudes of Medical Students and Rheumatologists to Placebo and Nocebo Effects: Threshold Concepts in Clinical Practice
Authors: Arnold Mark H , Finniss Damien , Luscombe Georgina M , Kerridge Ian
Published: June 2020

Introduction:

Understanding placebo and nocebo responses (context/meaning effects [CMEs]) is fundamental to physician agency. Specific instruction in CMEs is often lacking in medical education. Patient–practitioner interactions may challenge medical students’ understanding of biomedical causality and the nexus between this, practical ethics and professionalism across various conceptual and applied aspects of CMEs. This study compared the corpus of knowledge and phronesis related to CMEs between Australian graduate medical students and rheumatologists to gain a sophisticated understanding of this relationship to inform curriculum development.

Method:

In 2013 and 2014, the authors surveyed third-year medical students undertaking a graduate programme in an Australian medical school and Australian rheumatologists to ascertain their understanding of placebo and nocebo responses. The survey ascertained (1) the alignment of the respondents’ understanding of CMEs with accepted facts and concepts; (2) opinions on the ethical status of CMEs; and (3) responses to 2 scenarios designed to explore matters of biomedical causality, practical ethics and professionalism.

Results:

There were 88 completed surveys returned, 53 rheumatologists and 35 students. Similar proportions within each group identified CMEs, with most (n = 79/88 [89.8%]) correctly recognising a placebo (rheumatologists: 50 [94.3%], students: 29 [82.9%]) and approximately three-quarters (n = 65/88 [73.9%]) correctly recognising nocebo effects (rheumatologists: 39 [73.6%], students: 26 [74.3%]). Statistically significant differences between practitioners and students were observed in relation to the following: placebo responders and placebo responsiveness; placebos as a ‘diagnostic tool’; placebos usage in clinical practice and research, and nocebo effects.

Conclusions:

Physicians require an awareness of CMEs and the fact that they arise from and influence the effective agency of health care professionals. Curricular emphasis is needed to permit an honest assessment of the components that influence when, how and why patient outcomes arise, and how one’s agency might have neutral or negative effects but could be inclined towards positive and away from negative patient outcomes.
Avoiding the planning support system pitfalls? What smart governance can learn from the planning support system implementation gap
Authors: Jiang Huaxiong , Geertman Stan , Witte Patrick
Published: June 2020

The implementation of smart governance in government policies and practices is criticised for its dominant focus on technology investments, which leads to a rather technocratic and corporate way of ‘smartly’ governing cities and less consideration of actual user needs. To help prevent a mismatch between the demand for and the supply of technology, this paper explores what smart governance can learn from efforts in debates on planning support systems to close the ‘PSS implementation gap’. This gap refers to a long-standing discrepancy between the availability of planning support systems (supply) and the time-bound support needs of planning practice (demand). By exploring both the academic field of smart governance and the debates on the planning support system implementation gap, this paper contributes to the further development of smart governance by learning from the experiences in the planning support system debates. Two particular lessons are distilled: (1) for technology to be of added value to practice, it should be attuned to the wishes and capabilities of the intended users and to the specifics of the tasks to be accomplished, given the particularities of the context in which the technology is applied; and (2) closing the planning support system implementation gap reveals that knowledge on the context specificities is of utmost importance and will also be of importance to the smart governance developments. In conclusion, smart governance can and should become more aware of the role of contextual factors in collaboration with users and urban issues. This is expected to shift the emphasis from today’s technology-focused, supply-driven smart governance development, to a socio-technical, application-pulled and demand-driven smart governance development.
Inclusive participation, self-governance, and sustainability: Current challenges and opportunities for women in leadership of communal irrigation systems
Authors: Imburgia Laura , Osbahr Henny , Cardey Sarah , Momsen Janet
Published: June 2020

Genuine inclusive participation in the self-governance of communal irrigation systems remains a challenge. This article analyses the mechanisms of participation in irrigation water users’ associations (WUAs) with focus on women as leaders of those organizations by drawing on cases from a comparative, multicase mixed-method study in Ethiopia and Argentina. After having being a topic for decades in gender and development debates, in many irrigated areas of the world, WUAs continue to be male dominated at all levels, especially in influential positions. Findings in this article suggest that despite large socio-economic and cultural differences, the current water management systems in both research locations reinforce problems of unequal gender participation; women have more obstacles and constraints in establishing equal access in membership, participation, and decision making in irrigation management. The lack of inclusive participation and the low representation of women in leadership roles lead to WUAs being poorly rooted in their community of users. Incomplete social rootedness of WUAs jeopardizes their effectiveness and equality in water management and, as a result, affects long-term sustainability. Through analysis of empirical data of communal small-scale irrigation systems in both countries, the article discusses who participates, how and why they participate, and the reasons for low numbers of women in leadership roles within the WUAs. Finally, the article reflects on possible enabling conditions that could foster inclusive participation, increase the quantity and capacity of women in management and leadership roles, and the benefits this may bring to sustainable irrigation systems.
Transgenic T-cell receptor immunotherapy for cancer: building on clinical success
Authors: Oppermans Natasha , Kueberuwa Gray , Hawkins Robert E. , Bridgeman John S.
Published: June 2020

With the advent of immunotherapy as a realistic and promising option for cancer treatment, adoptive cellular therapies are gaining significant interest in the clinic. Whilst the recent successes of chimeric antigen receptor T-cell therapies for haematological malignancies are widely known, they have yet to show great success in solid cancers. However, immune cells transduced with T-cell receptors have been shown to traffic to and exert anti-cancer effects on solid tumour cells with some great successes. In this review, we explore the field of transgenic T-cell receptor immunotherapy, highlighting some of the key clinical trials which have paved the way for this type of cellular immunotherapy. Some trials have shown amazing clinical results, including long-term remissions and minimal toxicity, and can be looked at as an exemplar for this adoptive cell therapy. There have also been key trials where unexpected, fatal, off-tumour toxicity has occurred, and these trials have also been instrumental in shaping safer clinical trials, particularly regarding preclinical testing. In addition to previous trials, we analysed the current clinical trial space for T-cell receptor T-cell therapy, showing which trials are dominating in the clinic and which targets are being prioritised by researchers around the world. By looking at both past and current trials, we have been able to identify key drivers in developing transgenic T-cell receptor immunotherapy for the future.
An Assay on the Possible Effect of Essential Oil Constituents on Receptors Involved in Women’s Hormonal Health and Reproductive System Diseases
Authors: Sakhteman Amirhossein , Pasdaran Ardalan , Afifi Mehdi , Hamedi Azadeh
Published: June 2020

Aromatic herbal remedies, hydrosols, and essential oils are widely used for women’s hormonal health. Scientific investigation of their major constituents may prevent unwanted infertility cases, fetal abnormalities, and drug-herb interactions. It also may lead to development of new medications. A list of 265 volatile molecules (mainly monoterpenes and sesquiterpenes) were prepared from a literature survey in Scopus and PubMed (2000-2019) on hydrosols and essential oils that are used for women’s hormonal and reproductive health conditions. The PDB (protein data bank) files of the receptors (136 native PDB files) that involve with oxytocin, progesterone, estrogen, prolactin, acetyl choline, androgen, dopamine, human chorionic gonadotropin, luteinizing hormone, follicle-stimulating hormone, aromatase, and HER2 receptors were downloaded from Protein Data Bank. An in silico study using AutoDock 4.2 and Vina in parallel mode was performed to investigate possible interactions of the ligands with the receptors. Drug likeliness was investigated for the most active molecules using DruLiTo software. Aristola-1(10),8-diene, bergapten (5-methoxypsoralen), α-bergamotene, bicyclogermacrene, α-bisabolol oxide A, α-bisabolone oxide, p-cymen-8-ol, 10-epi elemol, α-elemol, β-eudesmol, 7- epi-β-eudesmol, ficusin, β-humulene, methyl jasmonate, nerolidol, pinocarvone, (+)-spathulenol, and thujone had better interactions with some androgen, aromatase, estrogen, progesterone, HER2, AChR, and/or dopamine receptors. Most of these molecules had an acceptable drug likeliness except for α-bergamotene, bicyclogermacrene, β-humulene, and aristola-1(10),8-diene. Some volatile natural molecules can be considered as lead compound for drug development to treat hormonal conditions.
Research on an electromagnetic device and pressuring force for measuring the depth of borehole while drilling the bone
Authors: Wang Xuan , You Fangyi , Hong Jian , Zhou Wang
Published: June 2020

A device for measuring the depth of the borehole base on the magnetic grid during orthopedic surgery is proposed in this article. It consists of a magnetic grid, winding sleeve, two Hall sensors, and control circuitry. The magnetic grid comprises permanent magnets and coil windings. The device fixes on the electric hand drill and works during the surgical operation. An axial pressure keeps the shaft end of the magnetic grid in contact with the surface of the bone or the plate steadily during the electric handheld drilling of the bone. The pressure is an electromagnetic force generated by the interaction between the permanent magnets and the coil windings. The force should be large enough to support the weight of the magnetic grid and a low fluctuation is maintained. The larger the device, the higher the electromagnetic force will be generated. The electromagnetic force is simulated and obtained with the software of Maxwell. The factors that influence the force were the permanent magnet, and the others are the length of permanent magnet and the turns on the coil. The results of orthogonal simulation show that the primary factor is the diameter of the permanent magnet. The optimized parameters include the following: the diameter of the magnet is 7 mm, length of each permanent magnet is 5 mm, and the turns on the coil are 80. Then the pressure force range is approximately 0.485–0.716 N, and the variance of the force is 0.137.
Fragility curve modifiers for reinforced concrete dual buildings, including nonlinear site effects and soil–structure interaction
Authors: Petridis Christos , Pitilakis Dimitris
Published: June 2020

We investigate the influence of soil–structure interaction (SSI) and nonlinear soil behavior on the seismic fragility of reinforced concrete (RC) dual (frame + shear wall) buildings resting on shallow foundations. This article includes a holistic methodology to account for nonlinear soil behavior and soil–foundation–structure interaction in a modular way. Using nonlinear dynamic analyses, we derive fragility curves for a wide set of building typologies and soil profiles, showing that soil behavior during strong shaking significantly affects the vulnerability of the soil–foundation–structure system. The influence of SSI is pronounced mostly for soft soil profiles, varying in a building-specific way. Post-processing of our results evolves into a set of fragility modifiers that enable risk analysts to massively account for soil-related and/or SSI effects in large-scale risk assessments.
Development of Polymeric Micelles of Oleanolic Acid and Evaluation of Their Clinical Efficacy
Authors: An Joo Young , Yang Hee Seon , Park Na Rae , Koo Tae-sung , Shin Bungchul , Lee Eun Hee , Cho Sun Hang
Published: June 2020

Oleanolic acid has been used only as a subsidiary agent in cosmetic products. The aim of the study is to show the effect of oleanolic acid as an active ingredient for the alleviation of wrinkles in humans and to develop a polymeric micelle formulation that enables poorly soluble oleanolic acid to be used as a main ingredient in cosmetic products for reducing wrinkles. The solubility of oleanolic acid was evaluated in solubilizers, surfactants, and polymers. The particle sizes and shapes of polymeric micelles containing oleanolic acid were evaluated by electrophoretic light scattering spectrophotometer and scanning electron cryomicroscopy. Encapsulation efficiency and skin permeation were measured by HPLC. Stability of the polymeric micelles stored at 40 °C for 3 months was evaluated by visual observation, particle size measurement, and oleanolic acid content measurement. Polymeric micelles in final product ampoule form were applied around the eyes of 23 female subjects for 8 weeks. Five skin parameters were evaluated by optical profilometry every 4 weeks for 8 weeks. In addition, professionals made visual observations of the skin and a human skin irritation study was conducted. Polymeric micelles of oleanolic acid with a particle size of less than 100 nm were prepared using Capryol 90® and poloxamer. The skin permeation rate of the oleanolic acid in the polymeric micelles was higher than that in the other solutions made of oleanolic acid dispersed in 2 different surfactants. No significant changes in particle size, color, or oleanolic acid content were observed, and the polymeric micelles stored at 40 °C for 3 months did not undergo phase separation. After 8 weeks of application, skin irritation had not developed and all five parameters evaluated by optical profilometry as well as the visual evaluation scores were significantly improved. This study showed that the polymeric micelles of oleanolic acid prepared in this study were stable and effective at alleviating wrinkles in humans as the principal active ingredient. Based on these findings, it is expected that polymeric micelles of oleanolic acid can be widely used in cosmetic applications.
Effect of Root Colonization by Arbuscular Mycorrhizal Fungi on Growth, Productivity and Blast Resistance in Rice
Authors: Campo Sonia , Martín-Cardoso Héctor , Olivé Marta , Pla Eva , Catala-Forner Mar , Martínez-Eixarch Maite , San Segundo Blanca
Published: June 2020

Background

Arbuscular mycorrhizal (AM) fungi form symbiotic associations with roots in most land plants. AM symbiosis provides benefits to host plants by improving nutrition and fitness. AM symbiosis has also been associated with increased resistance to pathogen infection in several plant species. In rice, the effects of AM symbiosis is less studied, probably because rice is mostly cultivated in wetland areas, and plants in such ecosystems have traditionally been considered as non-mycorrhizal. In this study, we investigated the effect of AM inoculation on performance of elite rice cultivars (Oryza sativa, japonica subspecies) under greenhouse and field conditions, focusing on growth, resistance to the rice blast fungus Magnaporthe oryzae and productivity.

Results

The response to inoculation with either Funneliformis mosseae or Rhizophagus irregularis was evaluated in a panel of 12 rice cultivars. Root colonization was confirmed in all rice varieties. Under controlled greenhouse conditions, R. irregularis showed higher levels of root colonization than F. mosseae. Compared to non-inoculated plants, the AM-inoculated plants had higher Pi content in leaves. Varietal differences were observed in the growth response of rice cultivars to inoculation with an AM fungus, which were also dependent on the identity of the fungus. Thus, positive, negligible, and negative responses to AM inoculation were observed among rice varieties. Inoculation with F. mosseae or R. irregularis also conferred protection to the rice blast fungus, but the level of mycorrhiza-induced blast resistance varied among host genotypes. Rice seedlings (Loto and Gines varieties) were pre-inoculated with R. irregularis, transplanted into flooded fields, and grown until maturity. A significant increase in grain yield was observed in mycorrhizal plants compared with non-mycorrhizal plants, which was related to an increase in the number of panicles.

Conclusion

Results here presented support that rice plants benefit from the AM symbiosis while illustrating the potential of using AM fungi to improve productivity and blast resistance in cultivated rice. Differences observed in the mycorrhizal responsiveness among the different rice cultivars in terms of growth promotion and blast resistance indicate that evaluation of benefits received by the AM symbiosis needs to be carefully evaluated on a case-by-case basis for efficient exploitation of AM fungi in rice cultivation.
What is the response profile of deciduous pulp fibroblasts stimulated with E. coli LPS and E. faecalis LTA?
Authors: Colombini-Ishikiriama Bella Luna , Dionisio Thiago Jose , Garbieri Thais Francini , da Silva Rafaela Alves , Machado Maria Aparecida Andrade Moreira , de Oliveira Sandra Helena Penha , Lara Vanessa Soares , Greene Andrew Seth , Santos Carlos Ferreira
Published: June 2020

Background

Oral fibroblast immunological responses to bacterial stimuli are well known. However, there are few studies about pulp fibroblasts from deciduous teeth (HDPF) responses, which are important for the treatment of pulp infections in children. The aim of this study was to evaluate expression and production of inflammatory cytokines and chemokines by HDPF when challenged with bacterial antigens normally present in advanced caries lesions.

Methods

Triplicate HDPF from 4 children (n = 4; 2 boys and 2 girls) were cultured by explant technique and challenged or not with Escherichia coli lipopolysaccharide/1 μg/mL (EcLPS) or Enterococcus faecalis lipoteichoic acid/1 μg/mL (EfLTA) for 6 and 24 h. Most of published studies employed immortalized cells, i.e., without checking possible gender and genetic variables. mRNA expression and protein production were evaluated by RT-qPCR and ELISA MILLIPLEX®, respectively, for Interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, Chemokine C-C motif ligand 2/monocyte chemoattractant protein 1 (CCL2/MCP-1), Chemokine C-C motif ligand 3/macrophage inflammatory protein 1-alpha (CCL3/MIP1-α), Chemokine C-C motif ligand 5/ regulated on activation, normal T cell expressed and secreted (CCL5/RANTES), C-X-C motif chemokine 12/ stromal cell-derived factor 1 (CXCL12/SDF-1), Tumor Necrosis Factor-alpha (TNF-α), Interferon-gamma (IFN γ), Vascular Endothelial Growth Factor (VEGF), Colony stimulating factor 1 (CSF-1) and Macrophage colony-stimulating factor (M-CSF).

Results

EcLPS increased IL-1α, IL-1β, IL-8, CCL2, CCL5, TNF-α and CSF-1 mRNA and protein levels while EfLTA was only able to positively regulate gene expression and protein production of IL-8.

Conclusion

The results of the present study confirmed our hypothesis, since pulp fibroblasts from deciduous teeth are capable of increasing gene expression and protein production after being stimulated with EcLPS and EfLTA.