bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of timing of adjuvant radiotherapy on locoregional control in patients with high-risk endometrial cancer
Authors: Díaz-cazáres Omar
Published: April 2023

Aim: High-risk endometrial cancer has a higher risk of regional and distant recurrence. We sought to examine our institutional experience regarding the timing of adjuvant radiotherapy and local failure (LF), locoregional failure (LRF), distant failure (DF), and overall survival (OS). Methods: We retrospectively reviewed a database of patients with high-risk endometrial cancer treated with sequential chemotherapy followed by adjuvant external beam radiation therapy (EBRT) with or without brachytherapy from 2012 to 2019. Results: One hundred thirty-one patients were identified. The median age at diagnosis was 65 (range 32-81). The most prevalent FIGO stages were IIIB (28.2%, n = 37), IIIC1 (19.8%, n = 26), and IIIA (17.6%, n = 23). Of the patients, 29% (n = 38) had positive lymph nodes and 71% (n = 93) had negative lymph nodes. The most prevalent histology was endometrioid (71%, n = 93), serous (12.2%, n = 16), clear cell (9.2%, n = 12), and other (7.6%, n = 10). Moreover, 100% (n = 131) of the patients completed EBRT. The mean EBRT dose was 49.6 Gy (range 45-50.4). The median number of days between surgery and EBRT was 212.4 days (range 103-219). The mean brachytherapy dose was 14.7 Gy (range 12-30). The cumulative incidence of LF was 6.1%, LRF was 19%, DF was 19%, and the median survival was 33.4 months. For patients who completed EBRT 180 days after surgery, LRF (HR 3.55 [1.23-10.2], P = 0.013), LF (HR 1.91 [0.4-8.9], P = 0.429), DF (HR 0.91 [0.41-2], P = 0.806), and OS (HR 0.92 [0.33-2.6], P = 0.87). Conclusion: In our cohort of patients with high-risk endometrial cancer treated with chemotherapy followed by radiotherapy, delaying RT was associated with an increased risk of LRF but no differences in DF or OS.
Emerging microporous materials as novel templates for quantum dots
Authors: Lee Jaeho , Wang Lianzhou , Hou Jingwei
Published: April 2023

Microporous structures have attracted significant attention in recent years. In particular, metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) have received considerable attention due to their tailorable structures that offer a wide range of choices in terms of molecular building blocks. Due to their high tunability, these materials are considered as ideal host matrices for templating and encapsulating guest materials, particularly quantum dots (QDs). QDs are investigated heavily for various applications such as light-emitting diodes (LED), biosensors, catalysts, and solar cells due to their unique properties from the quantum confinement effect. However, one of the drawbacks of QDs is their tendency to aggregate and exhibit low stability due to their small size and kinetic trapping in nanoparticle form. This perspective highlights promising approaches to enhance the performance and stability of QDs by using microporous materials as an encapsulation layer. Additionally, potential mitigating strategies are discussed to overcome current challenges and improve the practicality of QDs embedded in microporous nanocomposites.
The Impact of the COVID-19 Pandemic on Green Finance and Carbon Dioxide Emissions: Empirical Evidence from China
Authors: Chen Wei , Cai Shousong , Tian Yuan , Li Luxi
Published: April 2023

The Chinese government has expressed great confidence in the role of green finance in fulfilling its carbon neutrality commitment. However, the effectiveness of green finance, especially under the impact of emergencies such as the COVID-19 pandemic scenario, requires further examination. Using data from 2000 to 2020 in China, the correlation between green finance and carbon dioxide (CO2) emissions has been analyzed, both in BaU scenario and the COVID-19 scenario. The following conclusions were drawn: (1) In BaU scenario, green finance can effectively reduce CO2 emissions, especially through government green expenditure and green credit; (2) In COVID-19 scenario, although there is no direct relationship between the pandemic and carbon emissions, the data shows that the pandemic has hindered the progress of green finance, weakened its ability to curb carbon emissions, and indirectly led to an increase in carbon emissions. This study not only clarifies the mechanism by which the COVID-19 pandemic affects carbon emissions through the green finance system but also addresses the common problem of data scarcity in green finance research.
Analysis Driving Factors of Energy Consumption in the Road Transport Sector of the City in Douala, Cameroon
Authors: Fouda Mbanga Bienvenu Gael , Bissai Fontaine Dubois , Adiang Mezoue Cyrille , Nguiya Severin
Published: April 2023

The population growth, economic development and urbanization of the city of Douala in Cameroon are facing great challenges, particularly environmental and economic problems. However, there is an evolution of the road transport sector that has led to an excessive increase in the consumption of fossil fuels and over the last decades to an increase in greenhouse gases in the road transport sector. From this observation, no real policy has yet been put in place with a view to improving the energy efficiency of the transport sector. This work aim at analyzing the driving force factors of energy consumption in road transport in the city of Douala. In this study, a decomposition analysis through the Logarithmic Mean Divisa Index (LMDI) method is used during the period 2010-2019 to quantify their respective contributions in energy consumption. We have broken down road transport energy consumption into four main factors as main determinants such as: vehicle energy intensity, vehicle intensity, Gross Domestic Product (GDP) per capita and population. The results show that vehicle energy intensity, vehicle intensity, GDP per capita and population effect all have a positive impact on energy consumption and therefore main responsible for the increase in fuel consumption energy contributing respectively to 13.06%, 31.30%, 12.85% and 42.76% of the total variation of energy consumption. It is therefore necessary to implement several energy saving strategies in order to achieve a rationalization of energy consumption for a reduction of road transport energy. Political decision-makers must take such a study into account to better integrate the notion of sustainable transport.
Violencia simbólica y agresión en adultos de la provincia de Lima
Authors:   , Sac Alvarado Andrea Milagros
Published: April 2023

La presente investigación tiene como propósito indagar en la relación de la violencia simbólica y la agresión en población adulta de la provincia de Lima. Ello responde a la necesidad de ahondar el origen de la violencia en la sociedad limeña, la cual lidera los porcentajes de violencia a nivel nacional. El estudio es de tipo cuantitativo, con diseño no experimental correlacional transversal, y fue aplicado a una muestra de 259 adultos residentes de la provincia de Lima. Para la medición de las variables, se hizo uso de la Escala de Violencia Simbólica Intra e Inter Género y el Cuestionario de Agresión (AQ); ambos instrumentos contaron con propiedades psicométricas válidas para su aplicación. Los resultados denotan que existe una relación significativa positiva débil entre las variables estudiadas, lo que significa que, a mayor aceptación y asimilación de la violencia simbólica, mayores son los niveles de agresión en la población evaluada.
Características sociodemográficas y conocimientos básicos sobre Covid-19 asociados con el estado de vacunación en usuarios de un Centro de Salud
Authors:   , Pullo Huamani Flor María , Garamendi Torres Julia Maribel
Published: April 2023

Introducción: El COVID-19 es un serio problema global y la vacunación constituye la principal estrategia de prevención, siendo heterogéneo el nivel de avance en los países y en su interior. Para alcanzar óptimos niveles de vacunación contra COVID-19 se requiere identificar y abordar sus determinantes. Objetivo: analizar las características sociodemográficas, clínicas y de conocimientos básicos sobre la enfermedad asociados con el estado de vacunación contra la COVID-19. Hipótesis: Existe asociación entre las características sociodemográficas-clínicas y conocimientos con el estado de vacunación. Materiales y métodos: estudio observacional analítico de corte transversal, realizado entre mayo y junio del 2022, con 379 usuarios de un centro de salud. Utilizando una ficha de registro se recopiló variables sociodemográficas-clínicas y del estado de vacunación, y con un instrumento validado (Escala KNOW-PCOVID-19) se midió los conocimientos básicos sobre COVID-19. Se uso la prueba Chi cuadrado para identificar los factores asociados. Resultados: 83,38% de los usuarios se encontraban con vacunación completa contra COVID-19 y 71,77% manifestó intención de vacunación de una siguiente dosis. Se encontró diferencias estadísticamente significativas por grupos de edad, religión y embarazo (p<0.05), teniendo en cuenta que los jóvenes tienen mayor tendencia a vacunación incompleta; así mismo, el tener una religión cristiana o el estar embarazada predispone una intención a no vacunarse. Conclusión: el nivel de vacunación completa contra COVID-19 fue alta en usuarios de un centro de salud; siendo la edad, religión y embarazo las características asociadas. Es necesario la adopción de estrategias específicas para acelerar la vacunación contra COVID-19.
Evaluación de la influencia del tiempo de pre-irradiación en la terapia fotodinámica antimicrobiana en conductos radiculares infectados con Enterococcus faecalis: estudio in vitro
Authors:   , De Souza Peixoto Domper Karina
Published: April 2023

Objetivo: El estudio tuvo como objetivo evaluar la influencia in vitro del tiempo de pre-irradiación (TPI) en la terapia fotodinámica (TFD) en conductos radiculares infectados con Enterococcus faecalis. Métodos: Ciento veinte raíces de premolares humanos unirradiculares de un solo conducto previamente contaminados con Enterococcus faecalis fueron divididos en seis grupos según: G1, azul de metileno 0,005 % (TPI=0 min) con irradiación en láser diodo; G2, azul de metileno 0,005 % (TPI=1 min) con irradiación en láser diodo; G3, azul de metileno 0,005 % (TPI=3 min) con irradiación en láser diodo; G4, azul de metileno 0,005 % (TPI=5 min) con irradiación en láser diodo; G5, control positivo de hipoclorito de sodio (NaOCl 1%, 15 min); y G6, control negativo. Micro muestras del interior del canal fueron extraídas para hacer la medición de unidades formadoras de colonias (UFC/mL) antes y después del tratamiento. Resultados: La TFD disminuyó significativamente el promedio de UFC/ml de Enterococcus faecalis cuando fue aplicada con tiempos de pre-irradiación a 1, 3 y 5 min (p<0,001) que cuando el TPI fue de 0 min (p>0,05). El tratamiento solo con NaOCl tuvo una menor reducción frente a TPI 5 min, pero fue superior a TPI de 1 y 3 min. El TPI de 5 min fue el que presentó mayor % de reducción de UFC/ml de E. faecalis. Conclusión: El TPI tuvo influenció en la terapia fotodinámica antimicrobiana en los conductos radiculares infectados con Enterococcus faecalis.
Percepción entre tratamientos con brackets autoligantes y convencionales en una muestra ortodoncistas peruanos
Authors:   , Huayta Garcia Diego Alonso
Published: April 2023

Objetivo: Comparar la percepción entre tratamientos con brackets autoligantes y convencionales en una muestra de ortodoncistas peruanos. Materiales y Métodos: Una muestra de 168 especialistas en ortodoncia peruanos fueron encuestados para recolectar información sobre su percepción hacia los brackets convencionales y de autoligados en sus preferencias por fases de tratamiento, beneficios del paciente-consulta, y experiencias; y características demográficas y clínicas. Resultados: La preferencia total de brackets de autoligado (48,9 %) fue estadísticamente superior frente a los convencionales (18,8 %) (P<0,05). Los brackets de autoligado fueron preferidos en la mayoría de fases de tratamiento (46,4% a 63,7%; P<0,05), pero no en la finalización y acabado dónde resulto similar a los convencionales (P>0,05). La mayoría de ortodoncistas prefirieron el autoligado (40,5 % a 60,7 %) frente al convencional (4,2 % a 14,3 %) por la comodidad e higiene del paciente y tiempo de terapia, pero no cuando se trató del tiempo de control y precio (P<0,05). La mayoría de ortodoncistas requirieron menos de 10 casos para dominar la técnica de autoligado (59,5 %) y se sintieron cómodos con su uso (89,3 %) (P>0,05). No se encontraron diferencias significativas según el sexo (P>0,05), peri si respecto a años de experiencia (P<0,05). Conclusiones: La mayoría de ortodoncistas peruanos prefirieron los brackets de autoligado frente a los convencionales en la mayoría de fases de tratamiento, por motivos de comodidad e higiene del usuario y tiempo de tratamiento, y obtuvieron ventajas en el dominio y comodidad de uso, y se asociaron a una mayor experiencia profesional.
Uso de la plataforma moodle y la percepción de la enseñanza durante la etapa covid-19 en estudiantes de centros universitarios de turismo en Perú. 2021.
Authors:   , Berrocal Sedano Deysi Norka
Published: April 2023

La pandemia COVID-19 intensificó el uso de plataformas virtuales de aprendizaje, específicamente Moodle. El objetivo de esta investigación es determinar la existencia de una relación entre el uso de la plataforma virtual Moodle y la percepción de la enseñanza durante la etapa COVID-19 en estudiantes de Centros Universitarios de turismo en Perú, 2021. El estudio es de alcance correlacional, no experimental, aplicó 2 encuestas en el año 2021 para cada variable; además se obtuvo la participación de 80 estudiantes de turismo de tres universidades: Universidad privada San Martin de Porres, Universidad privada Antonio Ruiz de Montoya y Universidad privada Científica del Sur en Perú. Como consecuencia de esta investigación se determinó que existe relación entre el uso de la plataforma virtual Moodle y la percepción de la enseñanza de durante la etapa COVID-19 en estudiantes de Centros Universitarios de turismo en Perú – 2021. Sobre las conclusiones se demuestra que mientras más se utilice la plataforma Moodle, mejor será la percepción de la enseñanza de los estudiantes.
Sawsawan: Explicating the Culinary Heritage Significance of Philippine Condiments Using Bibliometrics (1972 - 2018)
Authors: Aster Karen Grace V. , Castillo Jaime Ramir B. , Cheng Shekaina R. , Trillana John Paulo L. , Varlez Ysabella Marie B. , Mercado Jame Monren Tapalla
Published: April 2023

The Philippine condiment, orsawsawan, comes in many forms such assuka(vinegar),toyo(soy sauce),patis(fish sauce), andcalamansi(Philippine lime), to name a few. This paper aims to create a bibliographic database surroundingsawsawanwith the goal of preserving the culture and adding information on Filipino heritage, as well as garnering attention and appreciation for Philippine condiments to further the nation's culinary heritage. The qualitative research approach was used to investigate three (3) themes of culinary heritage significance: aesthetics, social relevance, and symbolic context. A total of 523 definitions of varioussawsawanwere categorized into seven (7) themes:matubig, durog, pinreserba, sariwa, mamantika, may kapares, andpinaghalo. Through the bibliometric approach, the study showed thatsawsawanhas the potential to be more known locally and globally. About 56 references that discuss the culinary heritage significance of Philippine condiments have been found, ensuring the timeless nature of the rich Filipino culinary heritage. Some 26 publishers from four countries and 58 authors, mostly Filipinos, contributed to Philippine cuisine literature. Food enthusiasts, food writers and editors, and chefs will have a better understanding of each condiment and can choose the combinations that will work best for their dishes. This study may also be helpful as related literature to future scholars working on a related topic.
Relationship Between Balance and Vitamin D in Fibromyalgia Syndrome; A Prospective Cross-Sectional Study with HUR BTG4 Balance Master System®
Authors: TAŞ NEVSUN PIHTILI , Baykara Rabia Aydoğan , Erdal Ayse , Kal Gül Ayden
Published: April 2023

Background This study aims to show the relationship between balance and Vitamin D levels in Fibromyalgia. It also aims to raise awareness about the link between vitamin D levels, disease severity, and balance.Results Data were obtained from 86 patients with FMS and 47 healthy participants. There was a significant difference between the mean values of FIQ, VAS, and BBS in FMS (p < 0.05). A negative correlation was found between BBS and 25(OH) vitamin D levels in FMS (r: -0167, p < 0.05). There was a significant difference in the static balance data in the regression analyses between the groups (R: 0.40. R2:0.16 p:0.000). The regression analysis found that FIQ scores increased with the decrease in Vitamin D values (R: 0.41 R2: 0.17 p: 0.000).Conclusions Static balance is markedly impaired in low vitamin D levels. The deterioration in balance caused an increase in FIQ scores. Vitamin D has an important place in the treatment management of FMS and the correction of its negative effects on life. In addition to assessing balance, the information the device provides to improve individual activities will also improve the quality of rehabilitation.
An algorithm study for mask wear detection and recognition applied to hospital outpatient department personnel
Authors: Mei Jiefu
Published: April 2023

The widespread spread and spread of the COVID-19 outbreak poses a great threat to the economic development and physical and mental health of countries around the world. For typical places with great risk of virus transmission, such as hospitals, wearing protective masks has been verified to be an effective way to cut off the virus transmission and can significantly reduce the virus transmission rate. Based on this, the paper proposes a mask-wearing recognition algorithm based on Convolutional Neural Network (ConvNet) and Region Proposal Network (RPN) for people entering and leaving hospital outpatient departments. Firstly, the initial training sample library for mask wear recognition is established based on the actual filming images of the outpatient department. Second, to ensure the accuracy of the recognition algorithm, the initial training samples are expanded to improve the robustness in mask wearing recognition. Third, the convolutional neural network is trained and tested in Matlab software using the established database. At the same time, the captured images were segmented with the help of RPN to determine the candidate regions to realize the improvement of the convolutional neural network and enhance the recognition accuracy. The results show that accurate recognition of mask wear can be achieved using the established sample database. The application of the trained model to hospital outpatient departments can significantly reduce the risk of virus transmission and has excellent application prospects.
Effect of high-intensity laser therapy in patients with non-specific chronic neck pain: study protocol for a randomized controlled trial
Authors: Ortiz Hernán Andrés de la Barra , Arias Mariana , Miranda Luis Gómez , Liebano Richard Eloin
Published: April 2023

Background: Chronic non-specific neck pain (NP) is a common musculoskeletal disorder recognized for its high rates of disability and economic losses, ranking second in musculoskeletal conditions after low back pain. There are several effective physical therapy interventions to treat chronic nonspecific NP, among which there is the low-level laser therapy. High-intensity laser therapy (HILT) is a recent treatment proposed to reduce musculoskeletal pain; however, there are few studies that showits effects in reducing NP. The aim of this study is to evaluate the effect of high-intensity laser therapy on pain intensity in patients with chronic nonspecific NP.
Methods: This is a 2-arm, randomized, placebo-controlled trial with blinded evaluators. The research will be carried out in the laboratory of physical agents at the Andrés Bello University, Campus Casona de las Condes. Eligible participants include the entire internal and external community associated with Andrés Bello University suffering from chronic non-specific NP. Participants will be stratified by sex and randomized into 2 groups: group 1 (HILT and stretching exercises) and group 2 (shamHILT and stretching exercises). Treatments will be performed twice a week for 4 weeks with 3 assessments: before treatment (T0), at the end of treatment (T1), and 12 weeks after treatment (follow-up) (T2). The main outcomeswill be pain intensity at rest, pain intensity at movement, and pain pressure threshold. Secondary outcome measures will include neck range of motion and neck disability.
Discussion: In this study, HILT's effects on patients with non-specific NP will be compared to those of a sham laser intervention. This RCT will offer new evidence regarding the potential benefits of HILT in terms of pain intensity, range of movement, and disability in people suffering with non-specific NP.
Trial registration: NCT05689788
N6-methyladenosine reader RBMX is essential for motor cortex excitatory neuron survival in amyotrophic lateral sclerosis
Authors: he di , Liu Qiing , Liiu Liyang , Shen Dongchao , yang xuanzhe , wang chen , liu mingsheng , Zhang Xue , Cui Liyiing
Published: April 2023

Despite being one of the most common RNA modifications, the role of N6-methyladenosine (m6A) in amyotrophic lateral sclerosis (ALS) remains incompletely understood. The present study aims to explore the involvement of RBMX-mediated m6A posttranscriptional regulation in ALS pathophysiology. We examined the cellular effects of downregulating Rbmx in murine motor neuron cell line NSC-34, and the transcriptomic changes in human cell line HEK293T. The single cell sequencing dataset generated from primary motor cortex of ALS and control subjects was further analyzed, with the expression of RBMX-regulated genes compared between patients and controls across different cell types. Finally, the genetic variation landscape of m6A genes were inspected in a whole-exome sequencing (WES) cohort involving 508 ALS patients. We demonstrated that the disturbance of RBMX expression can induce transcriptomic changes selectively affecting excitatory motoneuron survival. The machine learning models identified several RBMX-regulated hub genes including TBKBP1. In addition, we found that the RBMX mutants affected the disease onset age and survival of ALS patients in a sex-dependent manner. Taken together, our integrated analyses highlighted the emerging roles played by RBMX affecting excitatory motor neuron viability in ALS, which may have important implications in understanding ALS pathogenesis.
Misalignment monitoring between electrodes and a rivet in a three-sheet resistance element welding-based dynamic resistance
Authors: Kim Mingyu , Jo Sooyoung , Lee Seung Hwan , Yu Jiyoung
Published: April 2023

Recently, resistance element welding (REW), a method for welding dissimilar materials is gaining popularity in the automobile industry. However, in a three-sheet REW process, in which a rivet is inserted into the middle sheet, stable welding quality cannot be guaranteed because the alignment of the rivet and electrodes cannot be visually inspected. In this study, the three-sheet REW of SPFC590 (structural steel), SABC1470 (high-strength steel), and Al6061 (aluminum alloy) was investigated. The welding quality was evaluated at an increasing misalignment, and it was compared to that of a 0-mm misalignment distance. The welding quality was significantly reduced from a 6-mm misalignment distance. The pre-contact process, which is designed for predicting misalignment, was applied prior to the actual REW process. The dynamic resistance waveform in the pre-contact process was significantly different at each misalignment distance condition because of the difference in each alignment with electrodes and workpieces. The features extracted from the dynamic resistance waveforms were applied to a deep neural network (DNN) model to monitor the misalignment between electrodes and a rivet. Because the weld quality (weld nugget diameter) was not satisfactory at distances greater than 6 mm, the threshold value of the misalignment distance was set as 6 mm. A neural network that can predict the state of the misalignment between electrodes and a rivet was designed and trained, and the misalignment was predicted with 100% accuracy from DNN model.
Anti-amnesic, antidepressant, and anxiolytic-like responses of curcumin-loaded nanocapsules in mice: Modulating acetylcholinesterase activity, oxidative parameters, and neuroinflammation biomarkers
Authors: Rodrigues Karline da Costa , Neto Manoel Rodrigues da Silva , Barboza Victor dos Santos , Hass Sandra Elisa , Vaucher Rodrigo de Almeida , Giongo Janice Luehring , Schumacher Ricardo Frederico , Wilhelm Ethel Antunes , Luchese Cristiane
Published: April 2023

This study aimed to investigate the action of two different formulations of curcumin (Cur)-loaded nanocapsules (Nc) (Eudragit [EUD] and poly (ɛ-caprolactone) [PCL]) in an amnesia mice model. We also investigated the formulations’ effects on scopolamine-induced (SCO) depressive- and anxiety-like comorbidities, the cholinergic system, oxidative parameters, and inflammatory markers. Male Swiss mice were randomly divided into five groups (n = 8): group I (control), group II (Cur PCL Nc 10 mg/kg), group III (Cur EUD Nc 10 mg/kg), group IV (free Cur 10 mg/kg), and group V (SCO). Treatments with Nc or Cur (free) were performed daily or on alternate days. After 30 min of treatment, the animals received the SCO and were subjected to behavioral tests 30 min later (Barnes maze, open-field, object recognition, elevated plus maze, tail suspension tests, and step-down inhibitory avoidance tasks). The animals were then euthanized and tissue was removed for biochemical assays. Our results demonstrated that Cur treatment (Nc or free) protected against SCO-induced amnesia and depressive-like behavior. The ex vivo assays revealed lower AChE and CAT activity, reduced TBARS, RS, and NSPH levels, and reduced IL-6 and TNF-\(\) expression. The treatments did not change hepatic markers in the plasma of mice. In conclusion, after treatments on alternate days, Cur Nc had a more significant effect than the free Cur protocol, suggesting a prolonged action of Cur in Nc. In addition, Cur EUD Nc showed a more significant improvement in this model.
Application of nested-qPCR-High resolution melting (HRM) technology on Strongyloides stercoralis isolates from Iran
Authors: Fakhrieh-Kashan Zohre , Fotouhi-Ardakani Reza , Zahabiun Farzaneh , Sharifdini Meysam , Kia Eshrat Beigom
Published: April 2023

Purpose
Strongyloides stercoralis is a parasite with special characteristics presenting it as a unique nematode. Iran is an endemic area for S. stercoralis. In this study, nested-qPCR-High Resolution Melting (HRM) technologies were applied on some human isolates of S. stercoralis from this country by focusing on evolutionary genetics analysis.
Methods
Twelve human isolates of S. stercoralis were collected from four endemic provinces of Iran. Genomic DNA was extracted from a single filariform larva for every isolate. Using specific primers targeting partial regions in cox1 gene, nested-qPCR-HRM was performed and melting-curve profiles were analyzed alongside with evaluation of genetic proximity and phylogenetic analysis using MEGA7 and DnaSP5 software.
Results
Melting temperature (Tm) values of the isolates were 77.9 ˚C - 78.3 ˚C. All isolates from Guilan, Mazandaran, and Khouzestan Provinces shared Tm values of 78.2 ˚C to 78.3 ˚C, while the isolates from Hormozgan Province showed Tm values of77.9 ˚C, 78.0 ˚C, and 78.1 ˚C. The phylogenetic tree illustrated that the sequences of the current study included nine haplotypes. Tajima's D index analyses showed that cox1 gene in S. stercoralis isolates was negative (Tajima's D = − 0.27).
Conclusion
The isolates were divided into five temperature groups. Although compare to PCR sequencing HRM assay identified more limited genetic changes, but it revealed that the mean of Tm of the isolates from Hormozgan Province was lower than those of other provinces, and represented specific haplotypes for this geographical region on the phylogenetic tree.
Pressure-independent thermal expansion and temperature-dependent bulk modulus
Authors: Yan Jinyuan
Published: April 2023

Both pressure-dependent thermal expansion and temperature-dependent bulk modulus are two essential thermal physical coefficients for high pressure temperature research. Negative temperature dependent bulk modulus were reported under the assumption of pressure independent thermal expansion. In this paper, it is proved that any pressure independent thermal pressure yields zero temperature dependent bulk modulus, instead of a negative.
Optimizing the performance of As(III) and As(V) adsorption process on magnetic carbon xerogel nanocomposites from aqueous solution and natural groundwater wells
Authors: Khamkure Sasirot , Cabello-Lugo María-Fernanda , Bustos-Terrones Victoria , Garrido-Hoyos Sofía-Esperanza , Pacheco-Catalán Daniella-Esperanza , Gamero-Melo Prócoro , Reyes-Rosas Audberto
Published: April 2023

This research focuses on generating magnetic adsorbents with less expensive precursors, a simple and cheap method of subcritical drying for xerogel, and easily recovered from the aqueous medium with magnetic properties for reducing impact of pollutants in the environment. The application of the response surface methodology (RSM) in optimization of As(III) and As(V) adsorption process on carbon xerogel nanocomposites (XMCs) from aqueous solution was proposed in this study under the scheme of a central composite design 23 with a central face. XMCs were synthesized from sol-gel polymerization of a resorcinol-formaldehyde composited with magnetite nanoparticles (MNPs) and carbonized at 600°C for 6 h. MNPs were incorporated into the structure of gels corresponding to the XRD, FTIR and SEM/EDX analysis. The varying stoichiometric of resorcinol/water ratios had a significant effect on the resulting texture and surface chemistry properties. The model obtained by RSM was able to acquire the optimal values of the variables (solution pH, dose, and initial concentration) to maximize the removal of As(V) and As(III) of 95±5.98% and 65±10.32%, respectively. The kinetic and equilibrium studies were well described by the pseudo second order and Freundlich isotherm, respectively. Thermodynamic analysis was endothermic and spontaneous in nature. The removal efficiency in groundwater found arsenic at levels lower than the WHO standards.
Engineering electrode interfaces for telecom-band photodetection in MoS2/Au heterostructures via sub-band light absorption
Authors: Kim Ji-Hee , Hong Chengyun , Oh Saejin , Dat Vu Khac , Pak Sangyeon , Cha SeungNam , Ko Kyung-Hun , Choi Gyung-Min , Low Tony , Oh Sang-Hyun
Published: April 2023

Transition metal dichalcogenide (TMD) layered semiconductors possess immense potential in the design of photonic, electronic, optoelectronic, and sensor devices. However, the sub-bandgap light absorption of TMD in the range from near-infrared (NIR) to short-wavelength infrared (SWIR) is insufficient for applications beyond the bandgap limit. Herein, we report that the sub-bandgap photoresponse of MoS2/Au heterostructures can be robustly modulated by the electrode fabrication method employed. We observed up to 60% sub-bandgap absorption in the MoS2/Au heterostructure, which includes the hybridized interface, where the Au layer was applied via sputter deposition. The greatly enhanced absorption of sub-bandgap light is due to the planar cavity formed by MoS2 and Au; as such, the absorption spectrum can be tuned by altering the thickness of the MoS2 layer. Photocurrent in the SWIR wavelength range increases due to increased absorption, which means that broad wavelength detection from visible toward SWIR is possible. We also achieved rapid photoresponse (~ 150 µs) and high responsivity (17 mA W− 1) at an excitation wavelength of 1,550 nm. Our findings demonstrate a facile method for optical property modulation using metal electrode engineering and for realizing SWIR photodetection in wide-bandgap 2D materials.
Sphingomyelin d18:1/14:0 activates TLR4 in metaflammation
Authors: Latz Eicke , Gorki Friederike , Dohnalová Lenka , Thaiss Christoph , Zurkovic Jelena , Christ Anette , Ohto Umeharu , Marzinek Jan , Bond Peter J. , Geißmar Eike , Singha Santu , Hamid Arslan , Yaghmour Mohamed , de Goede Kyra , Rothe Maximilian , Placek Katarzyna , Polzin Amin , Wollnitzke Philipp , Levkau Bodo , Fitzgerald Michael , Rutten Joost , Netea Mihai , Riksen Niels , Thiele Christoph , Pfeiffer Andreas , Düwell Peter , Bossche Jan Van den
Published: April 2023

Chronic low-grade inflammation, also called metaflammation, is associated with prevalent non-communicable diseases, such as atherosclerosis. Anti-inflammatory therapy provides a clinical benefit in patients, but the triggers that incite metaflammation remain largely unknown. To uncover non-genetic inflammatory factors influencing atherosclerosis severity, we performed an unbiased in vivo screen measuring thousands of host- and microbe-derived molecules in a mouse model of atherosclerosis. Machine learning-supported analyses identified, next to known pro- and anti-atherogenic factors, the medium fatty acid-chain sphingomyelin d18:1/14:0 (S14) as highly positively associated with atherogenesis. S14 activated macrophage innate immune signalling, immune-metabolic reprogramming and pro-inflammatory gene transcription. The inflammatory activity of S14 was TLR4- and MD-2-dependent, consistent with biochemical and molecular dynamics simulation analyses showing that S14 promoted the formation of active TLR4/MD-2 dimers. Human interventional and observational trials demonstrated that dietary changes altered concentrations of S14 and that increased circulating S14 was associated with carotid plaque development in obese individuals. Collectively, these findings identify an inducible endogenous ligand for TLR4 that drives metaflammation, providing the rationale for preventative approaches and pharmacological interventions that may curb detrimental inflammation secondary to Western-type lifestyle habits.
DAS coupling noise suppression based on MCA-FK
Authors: XU Yankai , Zhu Hongduo , Cao Siyuan , Chen Siyuan , Li Jiawei , Liu Hongwei
Published: April 2023

In recent years, distributed fiber acoustic sensor (DAS) technology has been applied for highprecision acquisition of vertical seismic profile (VSP) data, which has the advantages of high-density acquisition, low cost, safety and coordination. However, coupling noise with characteristics similar to that of the spring is produced and mixed in the VSP data collected by the distributed optical fiber in the well. The energy of the coupling noise tends to be very strong, resulting in the effective VSP data being covered. In this paper, coupling noise is constructed by analyzing its morphological characteristics. The dictionaries of coupling noise and clean VSP data are constructed respectively using their different characteristics, and the morphological component analysis (MCA) algorithm is proposed to separate them. The alternating direction multiplier method (ADMM) is used to solve the objective function, for which both L1 and L2 norm regularizations are adopted in the MCA algorithm. However, the performance of the algorithm heavily relies on the coefficient selection of the threshold, which can lead to noise residue in the denoised VSP data and effective signal attenuation due to the inappropriate selection of the threshold. Therefore, the frequencywavenumber (FK) transform is further used to extract VSP data from the separated coupling noise. The proposed MCA and FK transform (MCA-FK) algorithm is applied to the field data and has achieved good results.
High-volume evacuation mitigates viral aerosol spread in dental procedures
Authors: Malmgren Rasmus , Välimaa Hanna , Oksanen Lotta , Sanmark Enni , Nikuri Petra , Heikkilä Paavo , Hakala Jani , Ahola Aleksi , Yli-Urpo Simeoni , Palomäki Ville , Asmi Eija , Sofieva Svetlana , Rostedt Antti , Laitinen Sirpa , Romantschuk Martin , Sironen Tarja , Atanasova Nina , Paju Susanna , Lahdentausta Laura
Published: April 2023

Dental healthcare personnel (DHCP) are subjected to microbe-containing aerosols and splatters in their everyday work. Safer work conditions must be developed to ensure the functioning of the healthcare system. This study aimed to evaluate the risks that different dental procedures pose to DHCP, and the efficacy of high-volume evacuation (HVE) in risk mitigation. We studied virus-containing aerosol generation of four common dental instruments by simulating dental procedures. The air-water syringe produced the highest number of aerosols. HVE greatly reduced aerosol concentrations during procedures. The air-water syringe spread infectious virus-containing aerosols throughout the room, while other instruments only did so to close proximity. Additionally, infectious viruses were detected on the face shields of DHCP. Virus genomes were detected throughout the room, indicating that more resilient viruses might remain infectious and spread throughout the room. HVE reduced the spread of both infectious viruses and viral genomes. We recommend meticulous use of HVE, wearing a well-fitting mask and using a face shield in dental procedures. We advise particular caution when operating with the air-water syringe. Due to its lower aerosol production, the high-speed handpiece can be used as a substitute for the air turbine handpiece to reduce the risk of virus transmission.
Flood Damage and Shutdown Times for Industrial Process Facilities: A Vulnerability Assessment Process Framework
Authors: Friedland Carol J. , Orooji Fatemeh , Flynn Mathew L. , Assi Ayat Al , Mostafiz Rubayet Bin
Published: April 2023

Much of the U.S. petrochemical infrastructure is heavily concentrated along the western coast of the Gulf of Mexico within the impact zone of major tropical cyclone events. Flood impacts of recent tropical disturbances have been exacerbated by an overall lack of recognition of the vulnerabilities to process systems from water intrusion, as well as insufficient disaster mitigation planning. Vulnerability assessment methods currently call for the aggregation of qualitative data to survey the susceptibility of industrial systems to floodwater damage. A means to quantify these consequences is less often employed, resulting in a poor translation of the threat of flood hazards to a crucial element of the economy. This paper reviews flood damage assessment for industrial facilities and presents a component-level conceptual methodology to assess the consequences of flood events. To more effectively communicate loss potential from flood events, the proposed methodology utilizes synthetic estimation to calculate repair requirements, shutdown time, and direct cost.
Analyzing the impact of epidermoid and adeno tissue on cancer incidence whit a data mining approach
Authors: ghorbian mohsen
Published: April 2023

Early detection is the only way to effectively control diseases whose treatment can be challenging, expensive, and time-consuming. Identifying the influencing factors in the occurrence of disease can, therefore, reduce the time associated with diagnosis and provide a solid foundation for improving the prognosis and preventing patients' deterioration. Applying data mining techniques as a novel approach to the early detection of disease-causing agents can significantly assist the early detection. In this study, an attempt was made to investigate the effect of epidermoid and adeno tissues on the incidence of cancerous diseases such as bone, bone marrow, lung, and neck cancer by conducting a data mining process on cancer patient data sets. Hence, Implementing two data mining techniques, K-nearest neighbor and decision tree, on the data of patients with these four types of cancer, an attempt was made to evaluate their performance using the three criteria of accuracy, error ratio, and negative prediction value. The implementation of data mining techniques and evaluations of their performance indicates that the decision tree technique performed better with an accuracy of 89.10%, an error ratio of 14.04%, and negative prediction value of 77.71%. Also, based on the findings, contamination of epidermoid and adeno tissues does not affect the early detection of any of the four categories of bone, bone marrow, lung, or neck cancer. In other words, the infection of the two epidermoid and adeno tissues cannot be the cause of the four types of bone, bone marrow, lung, and neck cancer.
Randomized, double-blinded, placebo-controlled pilot study: Efficacy of faecal microbiota transplantation on chronic fatigue syndrome
Authors: Salonen Tapani Erkki , Jokinen Elina , Satokari Reetta , Lahtinen Perttu
Published: April 2023

Background
Chronic fatigue syndrome (CFS) is a disabling illness of unknown aetiology. Disruption of gut microbiota may play a role in several neurological disorders. In this study, the effect of faecal microbiota transplantation (FMT) on fatigue severity and health-related quality of life (HRQOL) in patients with CFS was evaluated
Methods
Randomized, placebo-controlled pilot trial. Patients and researchers were blinded to treatment assignment. 11 patients with CFS (10 female and 1 male, mean age 42.2 years and mean duration of CFS 6.3 years) were randomly assigned to receive either FMT from a universal donor (n = 5) or autologous FMT (n = 6) via colonoscopy. Patients’ HRQOL was assessed by using visual analog scale (VAS) and self-reporting questionnaires Modified Fatigue Impact Scale (MFIS), 15D and EQ-5D-3L. Patients’ HRQOL was evaluated at baseline, and 1 and 6 months after the FMT.
Results
The baseline VAS scores in the FMT and placebo groups were 62.4 and 76.0 (p = 0.29). 1-month scores were 60.0 and 73.7 and 6-months scores 72.8 and 69.5, respectively. Total MFIS scores in the FMT and placebo groups were 59.6 and 61.0 at the baseline (p = 0.80), 53.5 and 62.0 at 1 month and 58.6 and 56.2 at 6 months. Compared to the baseline scores, differences at 1 and 6 months were statistically insignificant both in VAS and in MFIS. The 15D and EQ-5D-3L profiles did not change after the FMT or placebo. FMT-related adverse events were not reported.
Conclusion
FMT was safe but did not relieve symptoms or improve the HRQOL of patients with CFS. Small number of study subjects limits the generalizability of these results
Trial registration
ClinicalTrials.gov Identifier NCT04158427, https://register.clinicaltrials.gov, date of registration 08/08/2019
When Roads Want to Be Dams: Looking to Dam Safety to Regulate Transportation Embankments
Authors: O’Shaughnessy Amanda , Dayioğlu Asli Y. , Davis Allen P. , Aydilek Ahmet
Published: April 2023

The potential for failure processes impacting transportation embankments temporarily impounding water has not been a common consideration in the design and management of these structures. However, changes in water elevations due to land development and climate change has prompted concern about impoundment on seepage rates and overall stability of the constructed embankments. This study was conducted to examine how different aspects of dam safety can be incorporated in transportation embankment management. Evolving issues pertaining to water impoundment were investigated, transportation and dam embankments were compared, current U.S. Mid-Atlantic state policies were summarized, and numerical modeling of seepage and slope stability was conducted to understand how example transportation embankments behave under various water impoundment scenarios. Performance assessment of granular materials commonly used in transportation embankments indicates their ability to withstand piping erosion but poor slope stability during rapid drawdown. Recommendations are provided on prioritizing evaluations of transportation embankments. Results demonstrate the need for infrastructure inventories and hydrologic research on this topic.
DILLo: an Italian lexical database for Speech-Language Pathologists
Authors: Beccaria Federica , Cristiano Angela , Pisciotta Flavio , Usardi Noemi , Borgogni Elisa , Galletti Filippo Prayer , Corsi Giulia , Gregori Lorenzo , Gagliardi Gloria
Published: April 2023

This paper describes a novel lexical resource for treating speech impairments from childhood to senility: DILLo - Database Italiano del Lessico per Logopedisti (i.e., Italian Database for Speech-Language Pathologists). DILLo is a free online web application that allows the extraction of filtered wordlists for flexible rehabilitative purposes. Its major aim is to provide Italian speech-language pathologists (SLPs) with a resource that takes advantage of Information and Communication Technologies for language in a healthcare setting. DILLo was designed based on an integrated approach that envisages fruitful cooperation between clinical and linguistic professionals. The 7690 Italian words in the database have been selected based on phonological, phonotactic, and morphological properties and their frequency of use. These linguistic features are encoded in the tool, which includes the orthographic and phonological transcriptions and the phonotactic structure of each word. Moreover, most of the entries are associated with their respective ARASAAC pictogram, providing an additional and inclusive tool for treating speech impairments. The user-friendly interface is structured to allow for different and adaptable search options. DILLo allows Speech-Language Pathologists (SLPs) to obtain a rich, tailored, and varied selection of suitable linguistic stimuli. It can be used to customize the treatment of many impairments, e.g., Speech Sound Disorders, Childhood Apraxia of Speech, Specific Learning Disabilities, aphasia, dysarthria, dysphonia, and the auditory training that follows cochlear implantations.
Tribological and Physicochemical Behavior of a Novel Palm Grease Blended with Zinc Oxide and Reduced Graphene Oxide Nano-Additives
Authors: Nassef Mohamed G. , Hassan Hassan S. , Nassef Belal G. , Nassef Galal A. , Elkady Marwa
Published: April 2023

Palm oil possesses promising properties which promote them to be a competitive alternative to mineral oils in the lubrication of machinery. Still, marginal oxidation stability, viscosity, and tribological properties remain critical issues for performance improvement. This paper synthesized palm grease with reduced graphene oxide (rGO) and zinc oxide (ZnO) nano-additives at different blending ratios. Grease samples were tested for the physicochemical and tribological characteristics. The results showed that the highest viscosity values are found in case of base oil mixed with 0.1 wt.% ZnO and 2 wt.% rGO, separately. ZnO additives enhanced the oxidation stability by 60% and shifted the pour point from 9 oC to 6 oC. Adding ZnO and rGO to the palm grease increased the load-carrying capacity between 30% and 60%, respectively, and reduced the friction coefficient by up to 60%. The wear scar morphology proved a high competency of the developed palm grease aggregates in comparison with lithium grease.