bluuebunny/crossref_metadata_2025 huggingface dataset:
Hysteria as a Trigger for Epidemic Decompression Sickness Following Hypobaric Hypoxia Training
Authors: Demir Abdurrahman Engin , Ata Nazim
Published: October 2022

INTRODUCTION: Although hypobaric hypoxia training (HHT) is an essential component of aviation physiology training, it poses a risk of decompression sickness (DCS). DCS can sometimes be observed as a cluster of cases, which is referred to as epidemic DCS. In this report, we aim
to evaluate an epidemic DCS episode that occurred following two consecutive HHT sessions.METHODS: A total of 16 trainees, all of whom were medical doctors, attended the aviation medicine training course in the aeromedical research and training center. They went through HHT in two
sessions, each with eight trainees.RESULTS: Following two HHT sessions, five Type 1 DCS cases occurred among 18 personnel (16 trainees and 2 inside observers). DCS incidence rate was found to be 27.77%. They were successfully treated with hyperbaric oxygen therapy (HBOT).DISCUSSION:
Since the DCS incidence rate was found to be higher than the average in such a short period of time, this cluster of cases was labeled as epidemic DCS. We carried out a thorough investigation into all possible causes by following some templates that were developed to conduct comprehensive
investigations into epidemic DCS episodes. According to the psychological arguments discussed here, we placed a special emphasis on hysterical and psychosocial components, among other probable factors. In cases where the possibility of hysteria and placebo-nocebo responses exist, it is appropriate
to conduct the training and treatment processes with these factors in mind. No matter what the triggering factor is and how the symptoms manifest, HBOT remains crucial in the treatment of DCS.Demir AE, Ata N. Hysteria as a trigger for epidemic decompression sickness following hypobaric
hypoxia training. Aerosp Med Hum Perform. 2022; 93(10):712–716.
Sleep, Workload, and Stress in Aerial Firefighting Crews
Authors: Sprajcer Madeline , Roberts Spencer , Aisbett Brad , Ferguson Sally , Demasi Damian , Shriane Alexandra , Thomas Matthew J. W.
Published: October 2022

BACKGROUND:The challenges of climate change and increasing frequency of severe weather conditions has demanded innovative approaches to wildfire suppression. Australia’s wildfire management includes an expanding aviation program, providing both fixed and rotary wing aerial
platforms for reconnaissance, incident management, and quick response aerial fire suppression. These operations have typically been limited to day visual flight rules operations, but recently trials have been undertaken extending the window of operations into the night, with the assistance
of night vision systems. Already a demanding job, night aerial firefighting operations have the potential to place even greater physical and mental demands on crewmembers. This study was designed to investigate sleep, fatigue, and performance outcomes in Australian aerial firefighting crews.METHODS:A
total of nine subjects undertook a 21-d protocol, completing a sleep and duty diary including ratings of fatigue and workload. Salivary cortisol was collected daily, with additional samples provided before and after each flight, and heart rate variability was monitored during flight. Actigraphy
was also used to objectively measure sleep during the data collection period.RESULTS:Descriptive findings suggest that subjects generally obtained >7 h sleep prior to flights, but cortisol levels and self-reported fatigue increased postflight. Furthermore, the greatest reported
workload was associated with the domains of ‘performance’ and ‘mental demand’ during flights.DISCUSSION:Future research is necessary to understand the impact of active wildfire response on sleep, stress, and workload on aerial firefighting crews.Sprajcer
M, Roberts S, Aisbett B, Ferguson S, Demasi D, Shriane A, Thomas MJW. Sleep, workload, and stress in aerial firefighting crews. Aerosp Med Hum Perform. 2022; 93(10):749–754.
Use of PLT-F channel and immature platelet fraction parameters in differential diagnosis of thrombocytopenia
Authors: Dorn O. Yu. , Klinova T. V. , Legacheva O. Z. , Tsikalenko E. A.
Published: October 2022

Establishing the true causes of thrombocytopenia is of paramount importance, since the tactics of managing patients depend on it. Obtaining information about the activity of thrombocytopoiesis until recently was possible only after examining the bone marrow, but modern laboratory diagnostic capabilities make it possible to evaluate thrombocytopoiesis by a comprehensive clinical blood test performed on a hematological analyzer using a fluorescent optical method (PLT-F). At the same time, in addition to the number of platelets in peripheral blood, information is available on the number of immature platelets (IPF) in absolute and relative terms.

   Objective: to evaluate the possibility of using the PLT-F channel and IPF parameters in the differential diagnosis of thrombocytopenia.

   We reviewed three clinical cases with different pathogenetic variants of thrombocytopenia (immune thrombocytopenia, thrombocytopenia in DIC and thrombocytopenia associated with bone marrow damage). In all cases, a clinical blood test was performed on a Sysmex XN 1000 hematological analyzer using the PLT-F channel. When using the PLT-F channel, parameters are available to differentiate thrombocytopenia according to the mechanism of pathogenesis. The absolute value of IPF is a criterion for the activity of thrombocytopoiesis in the bone marrow, while the relative value of IPF, namely the increase in this parameter, is a criterion for the loss of platelets in the peripheral bloodstream (destruction or increased consumption of platelets). The availability of obtaining diagnostic information about the activity of thrombocytopoiesis and loss of platelets in the peripheral bloodstream using a clinical blood test using the PLT-F channel on Sysmex XN hematological analyzers is of great clinical importance, since a clinical blood test, being a routine study, does not require special conditions for sampling biomaterial, and can be performed not only at the stage of diagnosis, but also during therapy monitoring.
Myeloperoxidase, troponin I and C-reactive protein in blood of patients before and after coronary artery bypass grafting
Authors: Sheshurina T. A.
Published: October 2022

The study of dynamics of laboratory markers before and after heart surgery makes it possible to predict the risks of postoperative complications. Troponin I is ‘the gold standard’ for diagnosing acute myocardial infarction, but with an increase in the marker after heart surgery, the interpretation of the results can be difficult. Therefore, the search for new combinations of laboratory markers can help in assessing the degree of myocardial damage after surgery, as well as the risk of complications. Myeloperoxidase as a new laboratory indicator is of interest, since there are many studies on the prognostic value of an increase in this marker in patients with coronary heart disease in the development of cardiovascular complications. In the present study, the dynamics of myeloperoxidase, troponin I, and C-reactive protein in patients (n = 60) with a confirmed diagnosis of coronary heart disease before and after elective coronary artery bypass grafting under cardiopulmonary bypass was assessed. The following results were obtained: an increased level of myeloperoxidase in blood plasma in patients before surgery is an additional indicator in assessing the risk of postoperative complications, regardless of the concentration of C-reactive protein. A correlation was found between the concentration of troponin I and the level of myeloperoxidase in the blood, as well as between the duration of cardiopulmonary bypass and the level of MPO 24 hours after surgery.
Improvement of information in determination of N-telopeptide of type 1 collagen molecules in complex of indicators of water-electrolyte metabolism
Authors: Solomennikov A. V. , Bogdanova S. L. , Tyukavin A. I. , Arseniev N. A.
Published: October 2022

This paper presents the results of an expert analysis of laboratory data of patients with pathology of the musculoskeletal system, obtained using an expert analytical system. The personal data of patients who had the index of N-telopeptide of type I collagen molecules (TP1NP) were analyzed. The complex of TP1NP connections in personal observations was established by comparing the structural features of the formation of a panel of ratios of indicators of water-electrolyte metabolism against the background of the dynamics of the analyzed osteomarkers. At the same time, two types of influence of TP1NP growth on the ‘final’ structure of the panel of electrolyte ratios were singled out from the general array and personally analyzed – a high influence of the complex of TP1NP-associated bonds at the intersystem level and at absolute values of TP1NP that go beyond > M + G. A detailed analysis of the recorded relationships is presented with the substantiation of the leading mechanisms for the formation of TP1NP-associated complexes using literary sources. The authors come to the conclusion that under conditions of ‘disturbing’ effects on the body, a pronounced reaction can be achieved, in particular, due to mutual multiplication (multiplication) of the effectiveness of various mechanisms without pronounced shifts in the absolute values of the analyzed indicator. At the same time, the increase in the quantitative indicator of TP1NP with a weak expression of its effect on the final structure of the panel of electrolyte ratios may correspond to the predominant effect on bone metabolism of other factors that go beyond the osteomarkers analyzed in the article, thereby determining the need to continue the search and deciphering different complexes. At the same time, the observations presented and analyzed in this work, which demonstrate a high degree of influence on the integral PSE of the TP1NP-associated complex, can be entered into the archive of the knowledge base and recognized in the routine interpretation of the obtained laboratory data on water-electrolyte metabolism.
Evaluation of exfoliative cytology in endometrial pathology
Authors: Karpova A. E. , Shabalova I. P. , Kasoyan K. T. , Sozaeva L. G. , Shahova O. B. , Mironov A. V. , Kuznezov R. E.
Published: October 2022

Objective. Determination of the significance of cytological methods in the diagnosis of non-tumor lesions and endometrial tumors.   Materials and Methods. 69 patients who underwent surgical treatment of hysterectomy or hysteroscopy with separate diagnostic scraping of the cervical mucosa and uterine cavity. The endometrial surface was scraped by Cytobrush. Part of the material was applied to a slide for conventional cytology (CC); the remaining material was placed into the vial for liquid-based cytology (LBC). The results were analyzed using SPSS Statistical Package (SPSS: An IBM Company).   Results. Histological examination of biopsy material revealed endometrial hyperplasia without atypia (20), atypical hyperplasia (2) and adenocarcinoma (11). The sensitivity of CC and LBC for hyperplasia without atypia was estimated at 100 %, the specificity at 88 % and 94 %, respectively; the positive predictive value at 77 % and 87 %, respectively, and the negative predictive value at 100 %. The sensitivity of CC and LBC for atypical hyperplasia and adenocarcinoma was estimated at 100 %, specificity at 96 %; positive predictive value at 87 % and negative predictive value at 100 %.   Conclusions. Exfoliative cytology of material from the uterine cavity can be used as an informative method for detecting endometrial cancer and hyperplasia.
Thrombosis on background of COVID-19 in middle-aged people
Authors: Khidirova L. D. , Ilyinykh N. P. , Madonov P. G.
Published: October 2022

This review presents the features of coagulopathy and thrombotic risk in COVID-19 in middle-aged people. A consistent increase in the D-dimer and the presence of thrombosis and PE in seriously ill middle-aged patients with COVID-19 was shown with a decrease in other blood clotting parameters, such as fibrinogen, platelets or antithrombin, which are associated with DIC syndrome. Therefore, there is a need to identify an increased risk of thrombotic events at an early stage and prevent thrombotic events and organ damage as much as possible. The use of thrombolytic therapy is also being considered. Currently, great efforts are being made by the international medical and scientific communities, the new coronovirus infection COVID-19 is a problem and the prognosis for hospitalized patients with COVID-19, especially in the critical form, continues to be unfavorable not only for elderly and old patients, but also for middle-aged patients. age. Despite the fact that this disease is considered multifactorial, thrombotic complications play an important role in the further prognosis in this category of patients.
Possibilities and limitations of platelet counting methods
Authors: Tsvetkova T. G. , Kalashnikova A. A.
Published: October 2022

Currently, the use of hematological analyzers makes it possible to quickly and accurately count the number of platelets in the vast majority of blood samples. In some cases, the automatic determination of this indicator may be incorrect, due to the limitations of the methods used. Monitoring the results of automatic platelet count is necessary when obtaining pathological values and is carried out by microscopic examination of a peripheral blood smear. The article describes the methods and limitations of automatic determination of the number of platelets, possible causes of erroneous counting and ways to correct the result. Morphological descriptions of the most common artifacts that affect the correct definition of this indicator are presented. Modern methodological approaches to solving the problem of correct platelet counting in EDTA-dependent pseudothrombocytopenia are highlighted.
Laboratory assessment of state of post-vaccination humoral immunity to infections with aerosol transmission mechanism
Authors: Ereshchenko A. A. , Gusyakova O. A.
Published: October 2022

The review considers questions about the place of laboratory diagnostics in preventive medicine, in particular, about the possibilities of using laboratory methods in controlling the vaccination of infections with an aerosol transmission mechanism (measles, rubella, mumps, chickenpox, influenza, pneumococcal infection, pertussis, diphtheria, COVID-19). The article highlights the main laboratory methods of seromonitoring (enzyme immunoassay, radial hemolysis reaction in gel, dot-immunoassay, antibody avidity determination, hemagglutination inhibition reaction, microneutralization reaction, FAMA, plaque suppression reaction), their advantages and disadvantages. Also presented a block of data on alternative biomarkers (enzymes, lipids, trace elements, hormones, etc.). which serve as potential predictors of vaccination efficacy. The search for new biomarkers of the effectiveness of the formation of post-vaccination immunity opens up new possibilities for predicting the effectiveness of vaccination, which makes their study a promising direction in the field of vaccinology and laboratory immunology.
Machine learning models for analysis of biomarkers of chronic periodontitis
Authors: Mudrov V. P.
Published: October 2022

Periodontitis is a multifactorial inflammatory chronic disease initiated by dysbiosis of the commensal microbiota of the oral cavity. With the advent of the multi-ohm approach, which creates datasets with multiple features, machine learning algorithms have become an important technique in translational research. The most effective methods for identifying highly specific interactions of biomarkers with clinical parameters and their implementation in interpretable accurate clinical diagnoses are machine learning algorithms.

   The aim of the study was to evaluate laboratory diagnostic indicators that are significant for predicting the severity of periodontitis using machine learning models.

   We examined 133 patients aged 22 to 73 years with a diagnosis of chronic periodontitis, as well as 53 people without periodontal pathology. After the examination and assessment of the condition of the periodontium of patients, a biological sample of the periodontal fluid was taken. Real-time PCR was used to evaluate periodontopathogenic microflora and mRNA of pro-inflammatory cytokines. Cells of innate and acquired immunity were evaluated in mixed saliva. Machine learning was performed using logistic regression algorithms, naive Bayes classifier, ‘the Random Forest’ with 25 % training. When trained to 25 %, the naive Bayes classifier showed an accuracy of 23 %, logistic regression – 29 %. ‘The Random Forest’ showed 100 % accuracy and selected the following biomarkers associated with periodontitis severity: Porphyromonas endodontalis; CD 3+, CD 14+, CD 19+5–B 27+ cells; mRNA IL-1β, IL-10, IL-18, GATA3, TNFa, TLR 4. In chronic periodontitis, there is a relationship between local indicators of the immune-inflammatory process, such as mRNA of pro-inflammatory cytokines, cells of the immune system, and the severity of pathology. In the analysis of a multifactorial disease such as chronic periodontitis, a machine learning model optimized for a large heterogeneous data set with a large patient sample should be used.
Analysis of negative outcomes of orthopedic treatment based on dental implants
Authors: Lets S. L. , Monakov V. A. , Kurchugina N. Yu. , Shestun E. M.
Published: October 2022

The message for the use of orthopedic structures based on dental implants is the high aesthetic, functional, articulatory aspects of their use. However, the analysis of modern literature sources shows that the orthopedic rehabilitation of patients with partial absence of teeth by fitting crowns based on dental implants has a rather high percentage of complications. Our clinical analysis of the results of orthopedic treatment based on dental implants in the long-term aspect in 267 patients aged 20 to 60 years, identified many clinical complications. We have studied 350 orthopedic structures, as well as 885 dental implants. A systematic analysis of the obtained clinical data made it possible not only to identify the detected complications after orthopedic treatment based on dental implants in the long term, but also to divide the identified complications into two groups: typical and typical-specific. For example, such complications as bone tissue atrophy at the site of dental implant installation (35.62%), lack of flush space (25.47%), dental deposits (21.14), physical mobility of the installed implant (13.63 %), peri-implantitis and mucositis (12.49%).
Oral status of patients in need of cancer chemotherapy
Authors: Makeeva I. M. , Komogortseva V. E. , Reshetov I. V. , Margaryan E. G. , Put V. A. , Kadzhoyan A. G.
Published: October 2022

The prevalence and detection of cancer in the world is steadily increasing. The most common methods of treating malignant neoplasms are chemotherapy and/or radiation therapy. Patients undergoing this treatment often experience oral complications. The most common complication is oral mucositis. According to the literature, the probability of its occurrence is from 20 to 80% [2, 3]. Oral mucositis and other complications have a negative impact on the quality of life of cancer patients. They face pain, difficulty eating, swallowing, and damage to the oral mucosa increase the risk of secondary infection.

Aim. Evaluation of the dental status of oncological patients starting chemotherapy treatment.

Material and methods. The study involved 94 patients aged 45 to 59, who were divided into three groups: 1 – malignant neoplasms of the maxillofacial region (n = 23), 2 – gastrointestinal tract (n = 39), 3 – breast (n = 32). To determine the dental status, the values of the DFM, PMA, OHI-s indices, as well as local factors contributing to the aggravation of the oral cavity (metal structures, sharp edges of the teeth) were studied. To assess the awareness of patients about the rules and methods of maintaining an individual hygienic state of the oral cavity, a survey of patients was conducted.

Results. The dental status of cancer patients was assessed. The average value of the DFM index in group I is 13.3 (high), in group II – 11.4 (high), in group III – 5.7 (medium). The average value of the OHI-S index in group I was 3.8 (poor), in group II it was 3.1 (poor), in group III it was 1.7 (poor). The average value of the PMA index in group I was 67 (severe degree of inflammation), in group II – 55.6 (moderate degree of inflammation), in group III – 30.8 (moderate degree of inflammation). According to the survey, low awareness of patients about the means and methods of monitoring individual oral hygiene was revealed. Risk factors have been identified in the form of sharp edges of teeth and metal structures that can contribute to the development of severe complications from the oral cavity during chemotherapy treatment.

Conclusion. According to the results of the study, an unsatisfactory dental status of patients with oncological diseases of various localization was revealed. The need for control by dentists is shown.
Analysis of the negative outcomes of the results of prosthetics with bridge-like orthopedic structures in the lateral sections of the dentition
Authors: Komlev S. S. , Bazhutova I. V. , Pugachev S. A. , Razumny V. A. , Zakharova I. A.
Published: October 2022

Introduction. In the last decade, there has been an increase in publications in the field of odontopreparation using robotic technologies in the literature. The study of patent and literary publications on this subject led to the conclusion that at present the key direction of dentistry is the improvement of various means, methods for diagnosing pathological conditions of the oral cavity through the use of robotic systems. Purpose – to study the long-term results of treatment with fixed bridge structures in the lateral sections of the dentition.

Materials and methods. We selected outpatient records of 54 patients who applied to the Samara Regional Dental Polyclinic in the period from 2015 to 2022 with a diagnosis of partial absence of teeth in the posterior region, who underwent orthopedic treatment using bridges. Subsequently, all these patients made a number of complaints about chronic inflammation of the mucous membrane from injuries caused by orthopedic structures, impaired self-cleaning from food residues, impaired fixation of the orthopedic structure, and in some cases, a fracture of the supporting part of the prosthesis or tooth stump.

Conclusions. Undoubtedly, for high-quality dental treatment, it is necessary to ensure high-quality visualization of the x-ray picture of the bone tissue in the area of the supporting teeth, as well as take into account excessive chewing loads that may occur during the operation of the bridge. A competent choice of an orthopedic design, as well as compliance with these conditions, makes it possible to ensure the long-term use of orthopedic prostheses with a high degree of probability.
The influence of orthodontic treatment on head posture
Authors: Mamedov Ad. A. , Timoschenko T. V. , Zangieva O. T. , Slynko A. Yu. , Ermakov A. S.
Published: October 2022

The article presents data of foreign authors on the influence of orthodontic treatment on head posture. Our own study of 102 patients with vertical type of growth and distal occlusion before and after orthodontic treatment was carried out. The effect of rotation of the occlusal plane on the head posture was studied.

Materials and Methods: 102 patients with vertical type of growth and distal occlusion were examined before and after orthodontic treatment. Performed cephalometric analysis using CBCT, analyzed the head posture before and after orthodontic treatment.

Results: There were significant changes in the parameters characterizing the head position NSL-VER (83,75-82,10), NL-VER (91,55-88,85), NSL-OPT (82,95-85,75), NL-OPT (74,80-76), NSL-CVT (92,80-96,70), NL-CVT (83,30-85,40), и OPT-HOR (81,55-78,15), CVT-HOR (91,90-90,50).

Conclusions: 1) Flattening of the occlusal plane during orthodontic treatment affects the position of the head 2) Orthodontic treatment doesn’t effect on bone structures ( SNA, SNB, ANB, WITS, Beta).
The influence of local controlled hypothermia on the postoperative period in the removal of wisdom teeth
Authors: Guseynov N. A. , Hammouri M. H. , Muraev A. A. , Ivanov S. Y. , Lezhava N. L. , Lukyanova E. A. , Zolotaev K. E.
Published: October 2022

Local hypothermia is used to control inflammation, pain, edema, neuroprotection, and reduce muscle lockjaw. Despite the frequent use of cooling in neurology, cardiology, orthopedic rehabilitation, and physiotherapy, there is little scientific literature on the use of controlled hypothermia in oral and maxillofacial surgery. The aim of our study was to develop and substantiate the clinical effectiveness of the method of controlled cooling of the soft tissues of the parotid-masticatory and buccal areas as an anti-inflammatory physiotherapeutic agent in patients after surgery for the removal of dystopic wisdom teeth. For this, local controlled cooling of the masticatory-buccal and submandibular regions was carried out using the ViThermo apparatus in the study group, and cryotherapy was carried out in the control group. As a result, local controlled hypothermia of the soft tissues of the parotid-masticatory and buccal areas at an external constant temperature of the mask of 18 °С allows you to reach 32–34.2 °С of the soft tissues of the specified area and mucous membrane, which is safe and sufficient to provide anti-inflammatory action in the postoperative period with complex tooth extraction wisdom.
Social, somatic and dental status of patients with burnout syndrome
Authors: Redinova T. L. , Zlobina O. A. , Tarasova Y. G. , Dmitrakova N. R. , Timofeeva V. N.
Published: October 2022

The article reflects the results of a study of the relationship of emotional burnout syndrome (EBS) with the social status of patients and its impact on the somatic health and oral health of 146 patients aged 25 to 57 years. The survey showed that patients exposed to EBS by social status are more often unmarried, are urban residents, more often suffer from pathology of the cardiovascular system compared with emotionally stable patients. Respondents with a high level of EBS often complain about dryness and discomfort in the oral cavity in the form of tightness and roughness of the oral mucosa. As the level of EBS increases, oral hygiene worsens, general kinetic mobility and adsorption activity of epithelial cells of the oral mucosa suffer. However, the intensity of caries, as well as the frequency of detection of inflammatory periodontal diseases, do not change significantly depending on the degree of EBS.
X-ray morphometric analysis of the position of the teeth relative to the occlusal plane in persons with physiological occlusion of the dentition
Authors: Davydov B. N. , Kochkonyan T. S. , Domenyuk D. A. , Dmitrienko D. S. , Domenyuk S. D.
Published: October 2022

According to the results of X-ray studies of 74 patients of youthful and first period of mature age with physiological occlusion, the boundaries of the variability of the inclination angles of premolars and molars to the occlusal plane were determined. Patients, taking into account the size of the interincisal angle of antagonizing medial incisors, were divided into three groups with protrusion (n=23), mesotrusion (n=33) and retrusion (n=18) types of dental arches. It was established that in patients of the first group in the upper jaw, the inclination angles of the first premolars (92.34±3.16°), second premolars (95.57±3.03°), first molars (91.31±2.56° ), second molars (83.52±2.45°) to the occlusal plane is statistically significantly higher than similar dimensional parameters (87.95±2.17°, 85.06±2.87°, 81.49±2.06°, 76.47±2.49°, p≤0.05) in patients of the third group. In people of the second group on the upper jaw, the indicators of the angles of inclination of the first premolars (90.23±2.65°), second premolars (88.36±2.36°), first molars (84.02±2.61°), second molars (78.64±2.17°) to the occlusal plane occupy an intermediate position between the angular values of the patients of the first and third groups. In patients of the first group in the lower jaw, the dimensions of the inclination angles of the first premolars (91.76±1.78°), second premolars (96.73±2.06°), first molars (100.45±3.18°), second molars (104.51±3.35°) to the occlusal plane is statistically significantly less than similar dimensional values (99.89±3.01°, 104.32±3.14°, 107.29±3.09°, 111, 72±2.08°, p≤0.05) of patients of the third group. In people of the second group on the lower jaw, the parameters of the inclination angles of the first premolars (94.49±3.05°), second premolars (101.52±2.87°), first molars (104.96±3.08°), second molars (109.21±2.75°) to the occlusal plane occupy a middle position between the angular values of the patients of the first and third groups. The proposed method for analyzing the angles of inclination to the occlusal plane is of scientific and applied significance in the formation of an information electronic database for standardization and certification of X-ray morphometric studies, as well as an adequate interpretation of the data of X-ray studies of the maxillofacial region in normal and under various pathological conditions.
Evaluation of the proliferative activity of cell cultures on nanostructured coatings for dental implants
Authors: Dolgalev Al. Al. , Choniashvili D. Z. , Yusupov R. D. , Ambartsumov M. G. , Didenko N. N. , Sergeev Y. A.
Published: October 2022

The success of implantation treatment largely depends on osseointegration – a stable connection of bone tissue cells with the implant surface. One of the key technical factors on which successful osseointegration depends is the biocompatible surface of the implant.

Materials and methods. The authors investigated three series of coatings on prototypes (samples) of titanium implants for biological compatibility: titanium dioxide (TiO2) films obtained by plasma activated atomic layer deposition (PEALD); titanium dioxide (TiO2) films obtained by sol-gel method; diamond-like carbon (DLC) films. Primary cultures of MSCs – mesenchymal stromal cells of rat adipose tissue were used to study proliferative activity.

Results. A total of 30 samples were examined, samples made of titanium grade VT6 without coating served as a control. Samples, TiO2 ALD 25 nm, DLC 100 nm and DLC 200 nm, on which cellular elements showed significantly high levels of proliferative activity showed high biological compatibility.
Features of the use of «Kollapan-L» when raising the mucous membrane of the bottom of the maxillary sinus
Authors: Bazhutova I. V. , Volov N. V. , Ivaschenko A. V. , Yablokov A. E. , Kolganov I. N.
Published: October 2022

In a significant number of patients suffering from partial absence of teeth, computed tomography determines a deficiency of bone tissue in the area of missing teeth. This in turn complicates the placement of dental implants. The modern dental market is widely represented by various osteoconductive and indifferent materials that allow restoring the missing volume of bone tissue. An analysis of the literature data demonstrates the highest efficiency of osteoconductive materials. Their most effective representative is Kollpan-L®. Target. To determine the features of the clinical use of Kollapana-L® during closed sinus lift. Materials and methods. Patient M., aged 54, complained of a partial absence of teeth in the upper jaw. When conducting a computed tomography study, it was revealed the need to use the osteoplastic material «Kollapan-L»® during the operation of a closed sinus lift. Conclusion. As a result of the study, it was revealed that the use of osteoplastic material «Kollapan-L»® allows to reduce various postoperative complications (pain, swelling), and also promotes accelerated regeneration of bone tissue in the area of the defect.
EFFECTS OF TIP STRUCTURE ON THE TURBINE BLADE TIP PHANTOM COOLING PERFORMANCE
Authors:   School of Energy & Power Engineering, Xi’an Jiaotong University, Li Feng , Liu Zhao ,   School of Energy & Power Engineering, Xi’an Jiaotong University, Shi Yan ,   China United Gas Turbine Technology Co., Ltd, Feng Zhenping ,   School of Energy & Power Engineering, Xi’an Jiaotong University
Published: October 2022

The blade tip region of the gas turbine is exposed to an extreme operating condition with a high heat load. The conventional cooling concept that places cooling holes on the tip would consume a lot of cooling air and lead to the reduction in thermal efficiency. Whereas phantom cooling was supposed to help cool the tip region without using additional cooling air. In this paper, numerical investigations were performed to forecast the tip phantom cooling effects caused by the blade ejections by implying the standard k-ω model. Then, phantom cooling performance was presented under the flat tip (FT) and the squealer tip (ST). Results show that the FT shows a better phantom cooling performance compared to the ST. The phantom cooling effects on the FT are distributed at the tip forepart and approach the pressure side (PS). Whereas, for the ST, traces of phantom cooling are barely detected on the PS rim.
ANALYSIS OF AN ENVIRONTMENTALLY FRIENDLY LIFESTYLE AND DISASTER ONLINE MEDIA USAGE TOWARDS RESISTANCE FACING THE FLOOD DISASTERS ON DOMPET DHUAFA VOLUNTEER
Authors: Baikhaki Ahmad
Published: October 2022

This research aims to 1) Describe environtmentally friendly lifestyle towards resistance facing the disasters, 2) Describe social media usage towards resistance facing the disasters, and 3)Analysis environtmentally friendly lifestyle and social media usage towards resistance facing the disasters. This research use qualitative metode that intend to understand real overview between environtmentally friendly lifestyle and social media usage towards resistance facing the flood natural disaster that already applied by Dompet Dhuafa Volunteer Community. The data collected through closed questionnaire (40 respondents), 6 written interview with affected resident, and 7 respondent through direct interview and written, that consisct of Disaster Media Online Editor, Expert, Academic, and Government. The result of this research is found fact that an environtmentally friendly lifestyle is one of social intervention strategies aimed to reduce the risk of flood and support establishing the resistance to facing flood disaster. Beside it, online media also giving information access, socialitation, and education related to disaster with interesting contents like infographic, short movie, as well as the other content so that it has a direct impact on people’s understanding of what kind of mitigation measures should be taken to reduce the risk of flood disaster.
ANALYSIS OF SATISFACTION VISITORS ON INCREASED PEOPLE`S INCOME TOURIST ATTRACTIONS IN CURUG NANGKA NATURAL TOURISM OBJECT HALIMUN SALAK MOUNTAIN NATIONAL PARK
Authors: Surahmat Mamat , Rosadi Rosadi , Retnowati Rita
Published: October 2022

This study aims to determine the relationship between the quality of infrastructure and visitor satisfaction, knowing the relationship between service personnel and visitor satisfaction, knowing the relationship between the quality of infrastructure and service officers together with visitor satisfaction and knowing the relationship between visitor satisfaction and increased community economic income. in the natural attractions of Curug Nangka, Mount Halimun Salak National Park. The approach used in this research is a mixed method explanatory sequential design, which is a method of data collection that begins with quantitative data collection and then continues with qualitative data collection to help analyze. This research will begin with data collection that begins with quantitative data collection, which examines three variables. Research variables that will be used in this study consist of independent variables (independent variables), namely the X1 variable quality of infrastructure, X2 service of officers and the dependent variable (dependent variable), namely the variable Y visitor satisfaction. The quantitative data will be deepened by collecting qualitative data, namely to obtain information about the effect of visitor satisfaction with an increase in people's economic income in the natural tourism object of Curug Nangka, Mount Halimun Salak National Park. The data obtained by distributing questionnaires using a Likert scale. The population in quantitative research is the total number of visitors in 2020, namely 28,974 people / person and a sample of 100 people was drawn while the population and sample for qualitative research were 47 natural tourism actors. The data analysis model in this study used quantitative and qualitative analysis. The quantitative analysis used single and multiple regression analysis and correlation while the qualitative analysis used Miles and Hubermann (1984). The results showed that there was a moderate relationship between the quality of infrastructure and visitor satisfaction, a strong relationship between officer service and visitor satisfaction, and a very strong relationship between the quality of infrastructure and service officers together with visitor satisfaction and knowing a positive relationship. between visitor satisfaction and the increase in people's economic income in the natural tourism object of Curug Nangka, Mount Halimun Salak National Park.
EVALUATION PROGRAM FOR INCREASING VALUE ADDED AND COMPETITIVENESS OF HORTICULTURAL PRODUCTS IN SUPPORTING SUSTAINABLE AGRICULTURE (EVALUATION RESEARCH ON THE MULYATANI GAPOKTAN IN BREBES)
Authors: Anggraeni Fajar , Rosadi Rosadi , Retnowati Rita
Published: October 2022

The purpose of this study is to evaluate the implementation of the program to increase the added value and competitiveness of horticulture through APBN funds that have been implemented by the Directorate of Processing and Marketing of Horticultural Products at the Mulyatani Gapoktan in Brebes Regency. This program is expected to support sustainable agriculture in Brebes district. The government strongly supports the development of shallot cultivation in Brebes district, which is the largest center for shallot commodities in Central Java. Increased added value can be obtained by farmers at the time of starting cultivation, post-harvest to marketing. By doing good and correct cultivation, it can increase the productivity produced (18 tons/hectare). The use of organic materials and reducing the use of chemical pesticides in onion cultivation is a form of added value obtained by farmers because the production costs for purchasing chemical pesticides reach 8% of the costs incurred. then if done postharvest properly and correctly it can reduce losses (damage) that occur so that the product has a high selling value. The added value of shallots obtained by Gapoktan Mulyatani is apart from the cultivation and postharvest processes, as well as in the marketing process of fresh and processed forms (fried onions, crispy onions, and onion paste), so that the shallot business can support sustainable agriculture because of the shallot business process. starting from upstream to downstream. The purpose of providing postharvest infrastructure assistance and shallot processing facilities at the Mulyatani Gapoktan in Brebes Regency by the Directorate of Horticultural Product Processing and Marketing is to implement a program to increase added value and horticultural competitiveness to improve the welfare of members of the shallot farmer group. So that the results of this evaluation will be used as a reference that this program can still be continued by involving other agencies so that the program runs according to the targets to be achieved.
INFLUENCE OF DISASTER KNOWLEDGE RELATIONSHIP AND ENVIRONMENTAL LEADERSHIP IN OVERCOMING FLOODS WITH FLOOD DISASTER PREPAREDNESS BEHAVIOR
Authors: Rumawak Sarah Agustina , Istiadi Yossa
Published: October 2022

The objective of this study is to describe and analyze the relationship between disaster knowledge and environmental leadership in dealing with floods and with flood disaster preparedness behavior in \with a total of 10,688 people. The sample was taken using a multistage proportional random sampling technique, namely choosing a village that was used as the sampling area and then choosing an area that was very prone to flooding, so that the Awio Village was selected with a sample of 30 respondents. The questionnaire consists of three instruments, namely the flood preparedness behavior instrument (30 questions), the disaster knowledge instrument (26 questions) and the leadership instrument (29 questions). Rating scale with five answer choices that have the lowest value of 1 and the highest value of 5, namely for positive statements and for negative statements otherwise. The results showed the relationship between knowledge and leadership simultaneously (F=280,802,sig=0,000, p0,05). The partial relationship of disaster knowledge contributes individually and significantly to disaster preparedness behavior (ꞵ=0.097, sig=0.028, p0.05) and leadership also contributes individually and significantly to disaster preparedness behavior (ꞵ=0.954, sig=0.000, p0.05). The results showed that the level of community knowledge was still low, because they did not know about the causes of the flood disaster (60% of respondents), the level of leadership was still low, it was seen that disaster preparation planning had never been carried out (50% of respondents), and the behavioral dimension was still relatively low with the percentage behavior does not care about the preservation of nature (40% of respondents). The study recommends collective leadership so that each individual will complement each other according to their strengths, so that it will increase the effectiveness of each phase of disaster management that has been planned.
SPATIAL ANALYSIS OF HYDROMETEOROLOGICAL VULNERABILITY OF NATURAL DISASTERS IN THE BOGOR REGION
Authors: Alkaesi Fuad , Kadar Isman , Istiadi Yossa
Published: October 2022

Bogor Regency has a fairly large potential for natural disasters in the province of West Java, particularly hydrometeorological natural disasters, floods, and landslides. According to the Bogor Regency BPBD, there are 15 sub-districts with high potential for natural disasters. If we look at the level of damage, natural disasters, floods, and landslides have a very high level of loss due to the lack of information obtained by the community on the possibility of disasters occurring nearby. To avoid disaster losses, disaster risk management measures are needed. One way to manage disaster risk is to perform spatial data analysis in the form of maps of areas potentially prone to flooding and landslides based on the parameters that cause flooding and landslides. The method used in this study is Weighted Scoring and the analysis of disaster risk data is done spatially using a geographic information system (GIS) with the help of ArcGIS Software. This study aims to analyze and map the potential distribution of vulnerability to runoff and landslides in the district of Bogor. The results of the analysis are maps of areas prone to runoff and landslides in the regency of Bogor which can be used as a reference for mitigating natural disasters as well as for recommendations in regional land use planning.
MODEL OF GREENHOUSE GAS EMISSION REDUCTION WASTE SECTOR IN DEPOK CITY
Authors: Fitrisari Agnesika , Rosadi Rosadi , Dewi Indarti Komala
Published: October 2022

Waste is one of the largest sources of greenhouse gas emission (GHG) at the global, national, and Depok city levels. The purpose of this study was to analyze various alternative of reduction policy scenarios of the GHG waste sector used simulation model with dynamic system approach. The simulation applied from 2020 to 2050. There are four scenarios: BAU scenario, the current waste management; A scenario, based on the Jakstrada program; B scenario, the application of methane gas captured technology on Cipayung landfill, IPAL communal, and Septic tank; C scenario which is the application of Jakstrada program and methane gas captured technology on Cipayung landfill, IPAL communal, and septic tank. The amount of GHG waste sector in Depok 2020 is 414.966,80 Tons CO2/year. The largest amount of emission was  originating from wastewater and waste accumulation in landfills, which is 232.053 Tons CO2/year and 173,864,8 Tons CO2/year. A scenario GHG is decreasing by 3,38%. B scenario is decreasing the GHG into 93,6% with 21,99% unmanaged waste and 7% burnt waste. C scenario was successfully decreasing 96,11% and 100% managed waste which is the most. For decreasing the GHG waste sector, it needs the waste management and the technology application are done simultaneously.
Emerging roles of mesenchymal stem cell-derived exosomes in gastrointestinal cancers
Authors: Wang Naijian , Pei Bing , Yuan Xinyi , Yi Chengxue , Wiredu Ocansey Dickson Kofi , Qian Hua , Mao Fei
Published: October 2022

Gastrointestinal tumours are the most common solid tumours, with a poor prognosis and remain a major challenge in cancer treatment. Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into multiple cell types. Several studies have shown that MSC-derived exosomes have become essential regulators of intercellular communication in a variety of physiological and pathological processes. Notably, MSC-derived exosomes support or inhibit tumour progression in different cancers through the delivery of proteins, RNA, DNA, and bioactive lipids. Herein, we summarise current advances in MSC-derived exosomes in cancer research, with particular reference to their role in gastrointestinal tumour development. MSC-derived exosomes are expected to be a novel potential strategy for the treatment of gastrointestinal cancers.
Proteus mirabilis and Klebsiella pneumoniae as pathogens capable of causing co-infections and exhibiting similarities in their virulence factors
Authors: Palusiak Agata
Published: October 2022

The genera Klebsiella and Proteus were independently described in 1885. These Gram-negative rods colonize the human intestinal tract regarded as the main reservoir of these opportunistic pathogens. In favorable conditions they cause infections, often hospital-acquired ones. The activity of K. pneumoniae and P. mirabilis, the leading pathogens within each genus, results in infections of the urinary (UTIs) and respiratory tracts, wounds, bacteremia, affecting mainly immunocompromised patients. P. mirabilis and K. pneumoniae cause polymicrobial UTIs, which are often persistent due to the catheter biofilm formation or increasing resistance of the bacteria to antibiotics. In this situation a need arises to find the antigens with features common to both species. Among many virulence factors produced by both pathogens urease shows some structural similarities but the biggest similarities have been observed in lipids A and the core regions of lipopolysaccharides (LPSs). Both species produce capsular polysaccharides (CPSs) but only in K. pneumoniae these antigens play a crucial role in the serological classification scheme, which in Proteus spp. is based on the structural and serological diversity of LPS O-polysaccharides (OPSs). Structural and serological similarities observed for Klebsiella spp. and Proteus spp. polysaccharides are important in the search for the cross-reacting vaccine antigens.