bluuebunny/crossref_metadata_2025 huggingface dataset:
The diagnostic accuracy of Serum microRNAs in detection of cervical cancer: A systematic review protocol
Authors: Ssedyabane Frank , Niyonzima Nixon , Ngonzi Joseph , Tusubira Deusdedit , Ocan Moses , Akena Dickens , Namisango Eve , Apunyo Robert , Kinegyere Alison Annet , Obuku Ekwaro A
Published: November 2022

Background: Cervical cancer remains a public health problem worldwide especially sub-Saharan Africa. There are challenges in timely screening and diagnosis for early detection and intervention. Therefore, studies on cervical cancer and cervical intraepithelial neoplasia suggest the need for new diagnostic approaches including microRNA technology. Plasma/serum levels of micro RNAs are elevated or reduced compared to the normal state and their diagnostic accuracy for detection of cervical neoplasms has not been rigorously assessed more so in low resource settings such as Uganda. The aim of this systematic review was therefore to assess the diagnostic accuracy of serum microRNAs in detecting cervical cancer.
Methods: We performed a systematic review following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) statement. We searched for all English articles in MEDLINE/PubMed, Web of Science, Embase, CINAHL, as well as grey literature through 2022. Our outcomes were sensitivity, specificity, negative predictive values, positive predictive values or area under the curve (1) for each microRNA. We used the quality assessment of diagnostic accuracy studies (2) tool to assess risk of bias of included studies. Our results are reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis for Diagnostic Test Accuracy studies (PRISMA-DTA)
Use of the review results: This systematic review will provide information on the relevance of microRNAs in cervical cancer. This information will help policy makers, planners and researchers in determining which particular microRNAs could be employed to screen, diagnose or monitor prognosis of cancer of the cervix.
Systematic review registration: This protocol has been registered in PROSPERO under registration number CRD42022313275.
Computational Radical-Scavenging Activity Investigation of Galantamine
Authors: Karadjova Veronika , Saso Luciano , Velkov Zhivko
Published: November 2022

Galantamine is a natural alkaloid witha proved antioxidant activity, which easily passes the blood-brain barrier. This makes it a reliable drug for the treatment of many human brain diseases.In this paper we report the results of quantum chemical calculations of the dissociationenthalpies of O-H and C-H bonds in galantamine. The results clearly show the propensity of galantamine to react with radicals in the living organisms.This includes an assessment of the stability of O-H and C-H bonds in it, as well as their acidity.In addition, hydride ion abstraction reactions such as occur with nicotine-amid-adenine-dinucleotide (NAD) are discussed here.
Parameters optimization of a nonlinear dynamic absorber for a nonlinear system
Authors: Nazari Mohammad Mahdi , Rahi Abbas
Published: November 2022

One of the important methods to prevent the intensification of the main vibration system is using a dynamic vibration absorber (DVA). A DVA is a mechanical subsystem used to reduce Vibration amplitude and prevent the main vibration system from resonance. This paper aims to use a nonlinear dynamic absorber as a cantilever beam with a concentrated mass at its end to reduce the amplitude of the intensified oscillator vibration. The primary vibration system consists of mass, nonlinear spring, and viscous damping, and a harmonic excitation force is applied to it, resonance the system. In this case, using a nonlinear dynamic absorber reduces the vibration amplitude. For this purpose, first, the kinetic energy and the potential energy of the vibration system are calculated, and then, using Lagrange equations, the governing equations are extracted. Due to the nonlinearity of the equations of motion, the multiple scales method is used to solve the governing equations. In the results, the effect of nonlinear DVA on reducing the amplitude of intensified oscillator vibration is well visible. The effect of the main parameters of nonlinear dynamic absorbers on the vibration amplitude of the initial system is also investigated. Finally, the vibration amplitude of the system is optimized as a target function by the genetic algorithm method, and the optimal parameters of the nonlinear dynamic absorber and the optimal vibration amplitude are studied. Considering the main resonant vibration system as a structure under earthquake, the results of this research in reducing the vibration amplitude can be widely used in earthquake engineering.
Risk factors for perioperative acute heart failure in elderly hip fracture patients and establishment of a nomogram predictive model
Authors: Tian Miao , Zhu Yanbin , Li Wenjing , Wang Yan , Tian Yunxu , Zhang Kexin , Li Xiuting
Published: November 2022

Objective
This study aims to explore the risk factors of perioperative acute heart failure in elderly patients with hip fractures and establish a nomogram prediction model.
Methods
The present study was designed as retrospective. From January 2020 to December 2021, patients who underwent surgical treatment for hip fractures at the Third Hospital of Hebei Medical University were included. Patients with heart failure were confirmed by discharge diagnosis or medical records. Samples were randomly divided into modeling and validation cohorts at a ratio of 7:3. The demographic and relevant clinic data of patients were collected. Univariate and multivariate logistic regression analyses were conducted by IBM SPSS Statistics 26.0, to obtain the risk factors of acute heart failure. R software was used to construct the nomogram prediction model.
Results
A total of 751 elderly patients with hip fractures were enrolled in this study, of which 138 patients (18.37%, 138/751) developed acute heart failure. Patients with heart failure were confirmed by discharge diagnosis or medical records. Respiratory disease (odd ratio, 7.135; 95% confidence interval, 3.615–14.081; P value, 0.001), cardiovascular disease (odd ratio, 2.250, 95% confidence interval, 1.214–4.170; P value, 0.010), ASA ≥ 3 (odd ratio, 13.733, 95% confidence interval, 7.465–25.265; P value, 0.001), and preoperative waiting time ≤ 2 days (odd ratio, 3.271, 95% confidence interval, 1.315–8.134; P value, 0.011) were the independent risk factors of perioperative acute heart failure in elderly patients with hip fracture. The area under the curve (AUC) of the prediction model based on the above factors was calculated to be 0.877 (95% confidence interval 0.836–0.918). The sensitivity and specificity were 82.8% and 80.9% respectively, and the fitting degree of the model was good. In the internal validation group, the area under the curve (AUC) was 0.910, the 95% confidence interval was 0.869–0.950.
Conclusions
Our nomogram model can be used to predict the risk of acute heart failure in elderly hip fractures during the perioperative period and provide guidance on the prevention of acute heart failure.
Surgical treatment of double aortic arch malformation combined with descending aortic arch dissection in adults: a case series
Authors: Min Xinping , Hu Zhipeng , Wang Zhiwei , Xia Jun
Published: November 2022

Background: Double aortic arch (DAA) combined with descending aortic arch dissection (DAAD) in adults is a rare aorta vascular disease. Due to the abnormal anatomy of the double arch and arch vessels, the clinical symptoms and surgical methods differ from those of typical aortic dissection.
Methods: This study was retrospective analysis of a case series involving three patients (mean age, 47.3 years) with DAA combined DAAD underwent total arch replacement or hybrid aortic repair from September 2010 to June 2019. The patients’ demographics, initial symptoms, comorbidities, surgical procedures, and outcomes are summarized.
Results: Total arch replacement plus frozen stent implantation under deep hypothermic circulatory arrest was performed for 2 patients，one of them developed disseminated intravascular coagulation and multiple organ failure postoperatively. Case 3 underwent a hybrid procedure with left subclavian artery revascularization and thoracic endovascular aortic repair. The symptoms of hoarseness and dysphagia were obviously improved during the follow up.
Conclusion: In addition to typical sudden chest and back pain, patients with DAA and DAAD may have hoarseness and dysphagia. Based on the development of DAA, total arch replacement or hybrid surgery may be is an optional treatment.
Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type Ⅱ diabetes: A systematic review and meta-analysis
Authors: Mousavi Seyedeh Sarah , Namayandeh Seyedeh Mahdieh , Fallahzadeh Hossein , Rahmanian Masoud , Mollahosseini Mehdi
Published: November 2022

Background: concerning ascending trend in prevalence of chronic type Ⅱ diabetes, prevention and the development of an effective approach after recognition of at risk individuals are crucial. The aim of this study is to investigate the influence of lifestyle modification and metformin interventions in the prevention of type Ⅱ diabetes developments.
Method: The search was conducted using PubMed, Google scholar, Scopus and Web of science data bases. The inclusion criteria include randomized controlled trials (RCT) which studied both lifestyle modification and metformin interventions in the population above 18 years old without history of any types of diabetes. After excluding studies with intervention time less than 6 months, systematic review and meta-analysis were performed to evaluate relative risk (RR) with confidence interval (CI) 95% of type Ⅱ diabetes development.
Results: data from 5 studies were included in meta-analysis. The population also consists of individuals with mean age of 50 years old with BMI and FBS of 35.5 and 104.7 mg/dl respectively. Participants’ range of prevention year was between 2-3 years with mean of 2.8 years. Lifestyle modification decreases the probability of the incidence of type Ⅱ diabetes by 25.3 % (RR: 0.747, 95% CI, 0.6 - 0.92) compared to the metformin intervention (p-value= 0.007). Our results indicate that long-term lifestyle modifications can prevent diabetes type Ⅱ and decrease diabetes mellitus incidence down to one-quarter in comparison to metformin.
Conclusion: lifestyle modification can be more efficacious than metformin in diminishing incidence of type Ⅱ diabetes. Therefore, lifestyle modification can be a therapeutic strategy for controlling type Ⅱ diabetes incidence especially in high risk individuals.
Preoperative Ultrasound-based Protocol for Optimisation of Fluid Therapy to Prevent Early Intraoperative Hypotension: A Randomised Controlled Study
Authors: Szabó Marcell , Pleck András , Soós Sándor Árpád , Keczer Bánk , Varga Balázs , Széll János
Published: November 2022

Purpose: We aimed to evaluate whether the implication of an ultrasound-based preoperative fluid therapy protocol can decrease the incidence of early intraoperative hypotension.
Methods: Randomised controlled study in a tertiary university department involving elective surgical patients of ASA 2-3 class, scheduled for elective major abdominal surgery under general anaesthesia with intubation. We randomized 40–40 patients; 38–38 were available for analysis. Conventional fluid therapy was ordered on routine preoperative visits. Ultrasound-based protocol evaluated the collapsibility index of inferior vena cava and lung ultrasound profiles. Scans were performed twice: 2 h and 30 min before surgery. A high collapsibility index (≥40%) indicated a standardised fluid bolus, while the anterior B-profile of the lung ultrasound contraindicated further fluid. The primary outcome was the incidence of postinduction and early intraoperative (0–10 minutes) hypotension (MAP<65 mmHg and/or ≥30% of decrease from baseline). Secondary endpoints were postoperative lactate level, urine output and lung ultrasound score at 24 h.
Results: The absolute criterion of postinduction hypotension was fulfilled in 12 patients in the conventional group (31.6%) and 3 in the ultrasound-based group (7.9%) (p=0.0246). Based on composite criteria, we observed 17 (44.7%) and 7 (18.4%) cases, respectively (p=0.0136). The incidence of early intraoperative hypotension was also lower: HR for absolute hypotension was 2.10 (95%CI 1.00–4.42) in the conventional group (p=0.0387). Secondary outcome measures were similar in the study groups.
Conclusion: We implemented a safe and effective point-of-care ultrasound-based preoperative fluid replacement protocol into perioperative care.
Trial registration: Clinicaltrials.gov, NCT05171608 (registered prospectively on 10/12/2021)
Assessment of Retinal and Choroidal Vessel Density and Nerve Fiber Layer Thickness Changes After Orbitotomy in Sever NON- Active Thyroid Orbitopathy Patients (A Retrospective Study)
Authors: Tehrani Mansoreh Jamshidian , Niktinat Hanie , Ebrahimiadib Nazanin , Jafari Bahzad , Rafizadeh Seyed Mohsen , Kasaee Abolfazl
Published: November 2022

Purpose: Evaluation the optical coherence tomography angiogram changes in non-active sever thyroid related ophthalmopathy patients after cosmetic bone decompression
Methods: included 18 patients (25 eyes) with severe not active not compressive (NANC) TED who were candidates for decompression surgery for cosmetic reasons and A 3 × 3 mm macular scan was used to measure vessel density and RNFL thickness. Whole macular vessel density, in its superficial, deep and choriocapillaris layers were evaluated. Whole macular vessel density, in its superficial, deep and choriocapillaris layers were evaluated. The following data was extracted for each of layers: superior and inferior hemispheres, fovea, parafoveal vessel density, its superior and inferior hemispheres, and temporal, superior, nasal, and inferior quadrant.
Results: The mean RPC increased postoperatively, which was statistically significant in small vessels of peripapillary area. (p-value=0.045).The mean RNFL thickness decreased after surgery and it was statistically significant in the peripapillary (p-value= 0.032) and -Inferior-Hemifield area (p-value= 0.036). The choriocapillaris changes were significant in Superior-Hemifield (p-value= 0.031) and Fovea (p-value= 0.03).
Conclusion: thyroid associated orbitopathy patients have a tendency to decrease vascular density and correlated with disease activity more than stage of orbitopathy. There was not a strong an even discrepant results in linkage of RNFL thickness and other optic nerve function tests and TED patients status and it is needed to do studies with more epidemiologic power and same methodology of study to be more comparable.
A novel acquired EGFR-SEPT14 fusion confers differential drug resistance to EGFR inhibitors in lung adenocarcinoma: a rare EGFR alteration report
Authors: Wang Weidong , Lv Wang , Wang Hui , Xu Yang , Yan Junrong , Shen Han-Ming , Shan Liqun , Hu Jian
Published: November 2022

Backgrounds: The rapid development of comprehensive genomic profiling facilitates the identification of rare epidermal growth factor receptor (EGFR) mutations; however, the clinical implications of these newly identified rare mutations were largely unknown.
Methods: A lung adenocarcinoma patient with leptomeningeal metastasis (LM) who was treated with various EGFR tyrosine kinase inhibitors (TKIs) was included in the study. Next-generation sequencing of 139 cancer-relevant genes was performed on the serial cerebrospinal fluid (CSF) specimens collected during the treatment. Simulated structural analysis and in vitro drug sensitivity were conducted to elucidate novel EGFR TKI resistant mechanisms.
Results: The patient was initially positive for EGFR 19-exon deletion (19-Del), and upon drug resistance to first-generation EGFR inhibitors and osimertinib, a previously unreported EGFR-SEPT14 (E25:S7) fusion was identified. The patient achieved a promising response after treating intrathecal pemetrexed plus second-generation EGFR inhibitors. Structural analysis suggested that the fusion protein and wild-type EGFR had similar secondary structures but distinct tertiary structures. In vitro studies demonstrated that EGFR-SEPT14 fusion itself was not oncogenic; however, it could function together with EGFR 19-Del to confer drug resistance to first-generation inhibitors and osimertinib while remaining sensitive to some second- and third-generation EGFR inhibitors.
Conclusions: Overall, this is the first study reporting EGFR fusions can serve as an acquired resistant mechanism to EGRR inhibitors in lung adenocarcinoma, which is potentially through heterodimerization with classic EGFR mutations, and the identification of its differential sensitivity to certain EGFR TKIs could facilitate personalized treatments to patients with rare EGFR alterations.
A multicenter, open-label, multiple-dose Phase Ib/II study evaluating the safety and tolerability of CS3008 (BLU-554) in combination with CS1001 in subjects with locally advanced or metastatic hepatocellular carcinoma (HCC) Research
Authors: Zhou Mingzhen , Liu Baorui , Shen Jie
Published: November 2022

Objective: The treatment model of targeted therapy combined with immunotherapy has become the treatment modality for hepatocellular carcinoma due to problems such as single drug resistance. This trial was designed to evaluate the safety and tolerability of the fibroblast growth factor receptor 4 inhibitor CS3008 (BLU-554) in combination with the anti-PD-L1 monoclonal antibody CS1001 in patients with locally advanced or metastatic hepatocellular carcinoma (HCC).
patients and methods: This multicenter, open-label, multidose Phase Ib/II trial enrolled patients with locally advanced or metastatic hepatocellular carcinoma (HCC). Patients received CS1001 1200 mg intravenously every three weeks and BLU-554 600 mg orally daily. The primary endpoint was objective response rate (ORR) as assessed according to RECISTv1.1.
Result: A total of 18 patients were screened, of which 8 patients were FGF19 positive. And only four patients ultimately received the combination of treatment CS3008 (BLU-554) and CS1001 after entry row review, with ORR of 50% and DCR of 100%, and only one patient had an immune-related adverse reaction.
Conclusion: Preliminary confirmation that CS3008 (BLU-554) in combination with CS1001 is safe and effective in the treatment of patients with locally advanced or metastatic hepatocellular carcinoma.
Registration number: NCT04194801
A Novel Light trapping for high efficiency a-Si:H/ μc-Si Micromorph tandem Solar Cells
Authors: Eghbali Ramisa , Khosroabadi Saeed , Shokouhmand Anis
Published: November 2022

The performance of a-Si:H/μc-Si:H tandem solar cell has been studied by using two-dimensional numerical simulation. In this work, after optimizing the thicknesses of each layer, light trapping techniques have been investigated to increase the photogenerated current in both sub cells. 1D- photonic crystal has been implemented as a broadband back reflector in a solar cell while to reduce the reflection from the surface of the top cell, two-layer anti-reflection, SiO2/Si3N4 has been suggested. In order to match the current density of sub cells as well as prevent the accumulation of carries in its interface, Tunnel Recombination Junction is required in the interlayer. Here, we have used n-μc-Si:H /p-μc-Si:H with a thickness of 10nm as a TRJ. Under global AM 1.5G conditions, the proposed cell structure had an open-circuit voltage of 1.38 V, a short-circuit current density of 12.51 mA/cm2, and a fill factor of 80.82%, corresponding to a total area conversion efficiency of 14%.
Comparison of saturated hydraulic conductivity estimated by empirical, hydraulic and numerical modelling methods at different scales in a coastal sand aquifer in Northern Ireland
Authors: Águila Jesús F. , McDonnell Mark C. , Flynn Raymond , Butler Adrian P. , Hamill Gerard A. , Etsias Georgios , Benner Eric M. , Donohue Shane
Published: November 2022

Hydraulic conductivity (K) is one of the most challenging hydrogeological properties to appropriately measure due to its dependence on the measurement scale and the influence of heterogeneity. This paper presents a comparison of saturated hydraulic conductivities determined for a quasi-homogeneous coastal sand aquifer, estimated using eight different methodologies, encompassing empirical, hydraulic and numerical modelling methods. The geometric means of K, determined using 22 methods, spanning measurement scales varying between 0.01 m and 100 m, ranged between 3.6 and 58.3 m/d. K estimates from Cone Penetration Test (CPT) data proved wider than those obtained using the other methods, while various empirical equations, commonly used to estimate K from grain-size analysis and Tide-Aquifer interaction techniques revealed variations of up to one order of magnitude. Single-well tracer dilution tests provided an alternative for making preliminary estimates of K when hydraulic gradients were known. Estimates from the slug tests proved between 1.2 and 1.6 times larger than those determined from pumping tests which, with one of the smallest ranges of variation, provided a representative average K of the aquifer as revealed by numerical modelling. By contrast, variations in K with depth could be detected at small scales (~0.1 m). Hydraulic Profiling Tool (HPT) system data indicated that K decreases with depth, which was supported by the numerical model results. No scale effect on K was apparent when considering the ensemble of results, suggesting that hydraulic conductivity estimates do not depend on the scale of measurement in the absence of significant aquifer heterogeneities.
Minimax optimal control problems for an extensible beam equation with uncertain initial velocity
Authors: Hwang Jinsoo
Published: November 2022

This paper is devoted to deal with the problem of minimax optimalcontrol problems of an extensible beam equation with distributed controlsand initial velocity disturbances (or noises). The existence of optimal solutionsfor distributed control with fixed disturbance, namely (Pv) problem, and the existenceof minimax optimal solutions without restricting the initial disturbancenamed (P) problem are proved. And we derive the necessary optimality conditionsfor optimal solutions of the (Pv) and (P) problems in form of Pontryagin’smaximum principle.
An output of Kirchhoff Plate Equation with Bilinear Boundary controls
Authors: ELKABOUSS ABELLA , Bouhamed Abdelhak
Published: November 2022

The current work focuses on the regional optimal control issue of the Kirchhoff Plate equation con- trols in a spatial domain Ω ⊂ R2, with constrained bilinear controls operating on the boundary of such an equation. It primarily concerns the tracking of a target state during the time interval[0,T], exclusively on a subregion of ω ⊂ Ω, minimizing a specified energy cost. Then we demonstrate that there is an optimal control, which is defined as a solution to an optimality system.
MSC: 93B05
THERAPEUTIC EFFECT OF COCKTAIL VS PROLOTHERAPY INJECTION IN CHRONIC PLANTAR FASCIITIS, A PROSPECTIVE CONTROLLED RANDOMIZED CLINICAL STUDY
Authors: Varma H.S. , Upadhyay Sachin , Vidyarthi A.
Published: November 2022

Introduction:- Plantar fasciitis is the most common cause of heel pain. It is a self-limiting condition. If causative factors are not addressed properly, it becomes chronic plantar fasciitis. Objectives:- The study aimed to evaluate the efficacy of 15 % hypertonic dextrose (treatment group) in the treatment of chronic plantar fasciitis through comparison with a cocktail group (control group). Design:- In this prospective controlled, randomized clinical study at N.S.C.B. Medical College Jabalpur, from 1 January 2020 to 31 September 2021. The statistical test used in this study isthe chi-square test and independent students t-test.A totalof 41 patients were taken intothe study. Patients were divided into two groups, In the Prolotherapy group (treating group) (n=18), a single shot of 15% Hypertonic dextrose injection was administered (1.2 ml of 50 % hypertonic dextrose, 1.8 ml distilled water and 1 ml of 2% lignocaine mixture)and the cocktail group (control group) (n=23) single shot of cocktail was given (1ml 40mg local methylprednisolone mixed with 1 ml distilled water and with 1 ml 2% lignocaine). During a 24-week follow-up period, pain intensity was measured using the visual analoguescale and American orthopaedics foot and ankle score, the measurements were undertaken before treatment and post-treatment weeks 4 and 12 and 24. Result:- In this study, both treatments were significantly effective in plantar fasciitis treatment for up to the 12th week. However the cocktail group (control group) was found to have a significantly better result at both the 4th week (AOFAS 93.17Ã‚Â±3.33, VAS 1.65Ã‚Â±.49 vs AOFAS 71.94Ã‚Â±5.46, VAS 4.54Ã‚Â±.71) and 12th week (AOFAS 90.43Ã‚Â±2.86, VAS 1.91Ã‚Â±.29 vs AOFAS 76.78Ã‚Â±4.12, VAS 3.94Ã‚Â±.64), but significantly better even up to 24th weeks (AOFAS 86.39Ã‚Â±4.20, VAS 2.35Ã‚Â±.71vs AOFAS 67.22Ã‚Â±4.19, VAS 5.00Ã‚Â±.34), (p-value <.001) in term of pain intensity and disability as compared to prolotherapy group (treating group). Conclusion:- This study showed a favourable outcome towards the cocktail injectionin terms of VAS and AOFAS score as compared to prolotherapy injection.
ANTICANCER STUDIES ON THE LEAVES OF TINOSPORA CORDIFOLIA (WILD) MIERS
Authors:   Department of Pharmacognosy, The Oxford College of Pharmacy, Bengaluru 560 068, Karnataka, India., Patel Geetha , M. Harshita ,   Department of Pharmacognosy, The Oxford College of Pharmacy, Bengaluru 560 068, Karnataka, India., D. Sathi ,   Department of Pharmacognosy, The Oxford College of Pharmacy, Bengaluru 560 068, Karnataka, India., M. Paarakh Padmaa ,   Department of Pharmacognosy, The Oxford College of Pharmacy, Bengaluru 560 068, Karnataka, India.
Published: November 2022

The aim of the study was to evaluate anticancer activity of the methanol and aqueous extracts of leaves of Tinosporacordifolia Wild Miers against a Human Breast Carcinoma Cell line(MDAMB231) by MTT assay. The coarse powder of leaf were subjected to Soxhletextraction and microwave assisted extraction using methanol and water as solvent. The IC50 values of aqueous extract of leaf followed by soxhlation and methanol extract of leaf by microwave extraction were found to be 59.85Î¼g/mL and 249Î¼g/mLrespectively in MDAMB231 cells in comparison to Standard Vincristine 14.41ÂµM whereas methanol extract of leaf by soxhlet and aqueous extract by microwave extraction did not possess any anticancer activity. This study suggests that Tinosporacordifolia can be useful in the treatment of breast cancer.
PETROGRAPHY AND HYDROTHERMAL ALTERATION OF ULTRAMAFIC BED-ROCKS OF SOUTH SIPILOU: IMPLICATION IN THE LATERITIC NICKEL MINERALIZATION (DEPARTMENT OF SIPILOU, WESTERN IVORY COAST)
Authors:   UFR Sciences Geologiques Et Minieres, Universite de Man, BP V20 Man, Cote dIvoire., Emmanuel Franck Gouedji Gnamba , Ouattara Zie ,   UFR Sciences Geologiques Et Minieres, Universite de Man, BP V20 Man, Cote dIvoire., Odon N CHO Clement ,   UFR Sciences Geologiques Et Minieres, Universite de Man, BP V20 Man, Cote dIvoire., Mita-Roland Cardioula Sangah ,   UFR Sciences Geologiques Et Minieres, Universite de Man, BP V20 Man, Cote dIvoire., Audet Marc-Antoine ,   Sama Nickel-CI sarl, 2 plateaux Vallons, 28 BP 1467, Abidjan 28, Cote dIvoire., Bakayoko Bouake ,   Sama Nickel-CI sarl, 2 plateaux Vallons, 28 BP 1467, Abidjan 28, Cote dIvoire., Coulibaly Yacouba ,   Laboratoire de Geologie de Ressources Minerales et Energetiques, UFR STRM, Universite Felix HOUPHOUET-BOIGNY dAbidjan-Cocody, 22 BP 582 Abidjan 22, Cote dIvoire., Olivier Boffoue Moro ,   UFR Sciences Geologiques Et Minieres, Universite de Man, BP V20 Man, Cote dIvoire.,   Laboratoire du Sol, de lEau et des Geomateriaux, UFR STRM, Universite Felix HOUPHOUET-BOIGNY dAbidjan-Cocody, 22 BP 582 Abidjan, Cote dIvoire., Picard Christian ,   Universite de Franche-Comte (UMR 6249), 16, route de Gray, 25000 BesanÃ§on, France ISTerre Universite Grenoble-Alpes (UMR 6245), France.
Published: November 2022

South Sipilou is an area containing lateritic nickel mineralization that developed on ultramafic rocks in the department of Sipilou-Biankouma in western Ivory Coast. The objective of this study was to characterize the petrography and hydrothermal alterations affecting these ultramafic bed-rocks and to understand their involvement in lateritic nickel mineralization. Then to compare them to the ultramafic rocks already characterized in the department of Sipilou-Biankouma. Thus, the macroscopic characterization of these rocks was carried out in the field. Then, microscopic observations on the petrography and the hydrothermal alterations were made on these rocks after the preparation of thin sections in the laboratory.The results indicated that the lithologies of the ultramafic bed-rocks of South Sipilou consist of strongly serpentinized dunites, more or less harzburgitic lherzolites and olivine orthopyroxenites. Their petrographic characteristics showed a similarity with the ultramafic bed-rocks of the nickel-bearing lateritic mineralization of North Biankouma, North Sipilou and differences with those of Samapleu, Yepleu, in the department of Sipilou-Biankouma. Also, the main hydrothermal alterations of the ultramafic rocks of South Sipilou are composed of silicification, carbonation and serpentinization. Only serpentinizationcontributed to the concentration of nickel in the bed-rock and within the lateritic profile.
GRADO DE COMPROMISO LABORAL PARA LA MEJORA DE UNA EMPRESA CONSTRUCTORA EN MEXICO
Authors:   PhD in Administration Sciences, Academic Researcher, Faculty of Accountancy and Administration, Autonomous University of Campeche., Manuel Patron Cortes Roger , Alberto Quijano Garcia Roman ,   PhD in Strategic Management and Development Policies, Academic Researcher, Faculty of Accountancy and Administration, Autonomous University of Campeche., Fernando Medina Blum M.A.D. ,   Master in Senior Management an PhD Candidate, Academic Researcher, Faculty of Accountancy and Administration, Autonomous University of Campeche., Guillermo Chuc Giselle ,   PHD inAdministration Management, Academic Researcher, Faculty of Accountancy and Administration, Autonomous University of Campeche., Alberto Perez Canul Carlos ,   PhD in Administration Sciences, Academic Researcher, Faculty of Accountancy and Administration, Autonomous University of Campeche., Monserrat Llanes Chiquini Charlotte ,   PhD in Administration Sciences, Academic Researcher, Faculty of Accountancy and Administration, Autonomous University of Campeche.
Published: November 2022

The construction sector is becoming more important every day in Mexico, due to population growth and its multiple needs for urban infrastructure, requiring for this purpose to have committed workers who allow the achievement of business objectives of development and growth. The objective of this research is to measure the degree of labor commitment of a construction company located in Mexico, with the purpose of influencing the improvement of the behavior of its personnel. First, a quantitative measurement was made and then the information was supplemented by qualitative interviews. A total of 30 workers that make up the company participate. The results indicate that the workers are moderately committed, because their participation and loyalty are not well defined. In addition, they have medium identification and belonging. Therefore, it is suggested to implement a strategic program for a culture of participation (empowerment), which includes greater initiative and autonomy for employees when sharing information and giving them greater control over their work performance, increasing trust, responsibility, and commitment to the company.
STUDY OF SPECTRUM OF HEMOGLOBINOPATHIES IN ADULT AGE GROUP DIAGNOSED ON HIGH PERFORMANCE LIQUID CHROMATOGRAPHY IN TERTIARY CARE HOSPITAL
Authors:   Junior Resident 3, Department of Pathology, Dr PDMMC Amravati., Patil Supriya , Laddha J.P. ,   Professor, Department of Pathology, Dr PDMMC Amravati., Soni R.R. ,   Head of Department and Professor, Department of Pathology, Dr PDMMC Amravati., Tayde Ashish ,   Associate Professor, Department of Pathology, Dr PDMMC Amravati., Patil Ashish ,   Assistant Professor, Department of Pediatric. GMC Yavatmal.
Published: November 2022

Background: Inherited abnormalities of hemoglobin synthesis (hemoglobinopathies) include a myriad of disorders ranging from thalassemia syndromes to structurally abnormal hemoglobin variants. Aims and Objectives: To study spectrum of hemoglobinopathies in adult age group diagnosed on HPLC in tertiary care hospital. Materials and Methods: The present study carried out in the deparment of pathology , DR PDMMC AMRAVATI over a period of 18 months from january 2021 to june 2022. A total of 800 cases were included in the present study. The age group of patients ranged from 19 years and above. HPLC , complete blood count, and peripheral smear examination were done in all the cases. Results and Discussion: In the present study total 800 patients were included out of which 134 cases displayed abnormal hemoglobin fractions on HPLC. It was seen that majority of the patients in study were in the 19yrs to 30yrs. The most common hemoglobinopathy observed in the present study was sickle cell trait (51.50 %) followed by Beta Thalassemia trait (26.12 %) and Sickle cell disease (16.42 %).HbDpunjab trait was observed in 3.74 % cases. Sickle cell Disease + Beta thalassemia trait ,HbE trait, HbE homozygous were observed in 0.74% cases each. Conclusion: Detection of Î²-thalassemia carriers and other structural variants will provide a preliminary insight to the prevalence of hemoglobinopathies in hospital based patients.Awareness can be created in an effort to prevent the birth of affected children.The present study is intended to contribute to the available data as the identification of these disorders is important epidemiologically and aids in prevention of more serious hemoglobin disorders.
TOLERANCE TO THE ISSUE OF HIJAB WEARING IN THE TRAVEL NOVEL 99 CAHAYA DI LANGIT EROPA BY HANUM SALSABIELA RAIS AND RANGGA ALMAHENDRA
Authors:   Student, Research Centre for Arabic Studies and Islamic Civilization, Faculty of Islamic Studies, UniversitiKebangsaan Malaysia., Nur Azierah Ab Ghani Siti , Lubis Firuz-Akhtar ,   Senior Lecturer, Research Centre for Arabic Studies and Islamic Civilization, Faculty of Islamic Studies, UniversitiKebangsaan Malaysia.
Published: November 2022

This study discusses the analysis of religious tolerance in the travel novel 99 Cahayadi LangitEropa by Hanum SalsabielaRais and RanggaAlmahendra from the aspect of tolerance to the issue of hijab wearing. Wearing hijab is an obligation for Muslim women because it symbolizes self -identity and aims to protect the auratfrom being seen by men who are not mahram. Through this travel novel, the issue of hijab-wearing is still a matter of public dispute because some people think that hijab is merely a trend today and many people try to wear it because of its beautiful and attractive design. There are also perceptions that hijab-wearing prevents working women from getting their dream job due to company policies. Therefore, this study analyses the tolerance on the issue of hijab-wearing in this travel novel to Europe by using the approach of Islam Rahmatan Lil Alaminconcept. This study is qualitative in nature using content analysis and documentation methods. This study finds that the internal factor which includes the religion and the external factor which includes the weather are likely to have influenced a person to show tolerant attitude towards other individuals.
INTRODUCTION DE LANACARDIER EN ZONE SOUDANIENNE ET EVALUATION DE SON IMPACT SUR LA DYNAMIQUE DE LOCCUPATION DES SOLS DE 1986 A 2022 (COTE DIVOIRE)
Authors:   Institut de Geographie Tropicale, Universite Felix Houphouet-Boigny, Abidjan, Cote dIvoire., Sylla Daouda
Published: November 2022

The objective of this project is to apply to some optical data, an object oriented classification approach for monitoring and detecting the changes of land cover in the north of Cote dIvoire where cashew is spreading. Two Landsat images TM (1986)/ETM+ (2002) and a Sentinel-2 (2022) are used in this research. The method is achieved through the monitoring of land cover from an object-oriented approach based on fuzzy logic. For this specific methodological approach, we resort to texture analysis and principal component analysisa change detection through a post classification method and the integration of the resulting map in a GIS. By this approach, we produced the lands cover of 1986 2002 and 2022 with Kappa coefficients at 86 88 and 87 % respectively. For the period of concern (1986-2022), the method allows spatializing and quantifying the land cover changes in this complex environment dominated by cashew.
COMPARATIVE ANALYSIS OF JUDICIAL APPOINTMENTS WITH REFERENCE TO USA, AUSTRALIA AND INDIA
Authors:   Student, Masters of Law Christ University., Khali Vahibaya
Published: November 2022

Appointment of judges in India in higher judiciary have been an issue since independence where even constituent assembly while drafting the constitution was in dilemma as to what method should be adopted to appoint a judge in the Supreme court and High Court. Ultimately, the power to appoint judges was given to executive to keep a check on higher judiciary to prevent nepotism and increase accountability and transparency. But this trend was reversed in 2nd judges case in 1993 when collegium system was formed by Supreme Court and President became bound to accept the recommendation of collegium system in the appointment of judges. Even SC struck down National Judicial Appointment Commission Act, 2014 (NJAC) to uphold judicial independence. In this paper author will study the judicial appointment process of 3 countries i.e., USA, Australia and India and will try to analyze the trend followed in India for appointment process by looking into the landmark cases and NJAC Act which was struck down in 2015 by SC and lastly giving recommendations to improve the appointment process to uphold transparency and accountability which is considered as sine-qua-none for good governance.
VARIATIONS IN COURSE OF SCIATIC NERVE IN ADULT HUMAN CADAVERS
Authors: Deepthi CNV
Published: November 2022

Most of the sciatic nerve course in individuals is normal and variations in sciatic nerve is seen in approximately sixteen to twenty five percent of cases. Often sciatica is misdiagnosed. Pseudo-sciatica occurs as a result of non-spinal etiological factors. Understanding the origin and course of sciatic nerve is needed to correctly diagnose sciatica. The present study is undertaken to determine the normal course of sciatic nerve, along with its variations. Material And Methods: The following study was conducted on variation of sciatic nerve found during routine dissection of 100 cadavers for teaching purpose, in the Department of Anatomy, Govt. Medical College, Kurnool and other medical colleges in Kurnool. There were no other gross anomalies or pathologies. The skin around the area was normal and no evidence of surgery was present. The gluteal region was dissected and Gluteus maximus muscle was reflected and exposing the sciatic nerve and Piriformis muscle. Result: The incidence of variation in sciatic nerve is very low and is noted firstly in the right side of the cadaver. The occurrence of variation is 16 in 100 cadavers. Eighty four cadavers showed normal course of sciatic nerve. Out of sixteen cadavers, ten cadavers showed variation related to type b ranging 62.5% of total variations seen. Four cadavers showed type c variation ranging 25 % of total variations. Two cadavers were seen with a variation of type e ranging 12.5%. Conclusion: Sciatic nerve is the thickest, largest and longest nerve in the body. Its pathologies are also frequent in occurrence in daily life. A thorough knowledge of its anatomy and variations of sciatic nerve is required to give proper treatment plan to the patient. Also the, significance of it should not be overlooked during surgical and popliteal nerve block anaesthetic procedures.
IMPROVEMENT IN BIRTHING EXPERIENCE FOLLOWING CHANGE IN EPISIOTOMY PRACTICES AT TEACHING HOSPITAL IN INDIA
Authors: Kadam Shweta , Bangal Vidyadhar , Borawake Sai
Published: November 2022

Background:- Episiotomy or perineotomy is a minor surgical procedure performed in labour room to facilitate delivery of the baby and to prevent injury to perineum. The analysis of the labour room statistics revealed that the rate of episiotomy was extremely high (87%).The episiotomy wound related complications resulted in extended hospital stay and unsatisfactory birthing experience among the delivered women. Methodology:- Different methods of root cause analysis like Fish bone analysis and Five Why method were used at Pravara Rural hospital,Loni a tertiary care hospital. Necessary educational programmes were implemented and policy decisions regarding indications of episiotomy were made. Regular monitoring and analysis was done to sustain the results. Results:-The historical data of three months before project implementation revealed that the rate of episiotomy was 87.00% among 1691 deliveries conducted. The reduction in rate of episiotomy was predominantly observed in multipara. At the end of eight weeks of QI project, the rate of episiotomy in primipara and multipara was 70.20 % and 20.00% respectively. The overall incidence of surgical site infection (SSI) in the obstetric unit decreased from 3.2 percent to 2.5 percent. Conclusion:- Implementation of quality improvement project helped in significant reduction in the rate of episiotomy. It indirectly helped in reduction of episiotomy related complications and hospital stay.
NOONAN SYNDROME - A CASE REPORT
Authors: Pagare Jaishri , Chormale Ankita , Kasat Vikrant , R. Rohini , Akolawala Rashida
Published: November 2022

Noonan syndrome (NS) is an autosomal dominant inherited disorder. NS can be confirmed genetically by the presence of any of the known mutations. However, despite identification of fourteen causative genes, the absence of a known gene mutation will not exclude the diagnosis, as there are more undiscovered genes that cause NS. A well-known oral manifestation of Noonan syndrome is multiple unerupted teeth. Thus, the diagnosis of NS is still based on clinical features.We report a case of 16 year old female with the distinct clinical features of Noonan syndrome who has similar family history.
MODELLING FIELD WORKABLE DAYS ON FERRALSOLS IN CAMEROON
Authors:   PhD Student, Department of Agricultural Engineering, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Cameroon., Jiofack Ngu Ludovic , Fru Fonteh Mathias ,   Professor, Head of Department, College of Technology (COLTECH), University of Bamenda, Cameroon., Ndongo Barthelemy ,   Assistant Professor, Department of Agricultural Engineering, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Cameroon., Roger Njila Ntankouo Cesaire ,   PhD, Department of Agricultural Engineering, Faculty of Agronomy and Agricultural Sciences,University of Dschang, Cameroon.
Published: November 2022

The absence of accurate field operation time records may result to wasteful use of the time available for farm operation which reduces the possibility of a successful operation. Making decisions related to whether or not the soil is suitable for farm activities is essential. However, about 70% of Cameroons soils are ferralsols and there is little to no data on how they respond to pressure from farm machinery intensities at different levels of moisture content. For the Bimodal Humid Forest Agroecological Zone of Cameroon, a model was developed to estimate soil suitability and the effective time available for farm operations on ferralsols. To achieve this goal, pot and field experiments were carried out to observed how bulk densities changes under different traffic intensities at various soil moisture levels. Also, NetBeans Integrated Development Environment (IDE) was used to develop a model in JAVA language that isran by a desktop. It was found thatferralsols have four main types of soil texture: Sandy Clay Loam, Clay, Sandy Clay, Clay Loam.Also, compaction caused by farm machinery traffic in these soils at depths of 0-15 cm tends to be greater than that at depths of 15-40 cm, which did not vary much moisture content at wilting point (MCWP) was found to be between 10% and 15%, and critical moisture content (CMC) ranged from 25.88% to 38.32%. Furthermore, ferralsols reach their optimum bulk density at moisture contents higher than field capacity. The NGUTRACT model developed permits to determine if a day was workable or not based on several variables and consequently permit to determine the number of days in a year. As a result, the model is site-specific, and depending on the soil type and moisture content, a day may be workable for one farmer while being non-workable for another in the same location.However, in order to provide a comprehensive picture of the entire agroecological zone, the results should be extended to the East and South regions. NGUTRACT should be used in conjunction.
DIGITAL CONTROL OF BUCK CONVERTER USING ARDUINO AND 8051 MICRO-CONTROLLER
Authors:   SDM College of Engineering and Technology, Dept of EEE, Dharwad- 580002, India., D. Ghalagi Chinmay , Azeem Y. Mohammad ,   SDM College of Engineering and Technology, Dept of EEE, Dharwad- 580002, India., Wahid G. Mohammad ,   SDM College of Engineering and Technology, Dept of EEE, Dharwad- 580002, India., Nare Rohit ,   SDM College of Engineering and Technology, Dept of EEE, Dharwad- 580002, India.
Published: November 2022

The recent advancement in the domain of processors of embedded modules and integrated systems has put on the requirement of high performance, uninterrupted quality of power supply for its accurate and quality performance. For this accurate and quality power supply, the power electronic converters play a vital role. In this conversion process there is always a fluctuation in a voltage levels and this will affect the life span of electronic components along with quality of the result being produced. The DC to DC conversion plays vital in case of electronic components. This paper is going to discuss about one of the methods that will control or reconfigure the output from the converter. With the use of micro-controllers that maybe 8051 Micro-controller or by Arduino that contain ATmega328P digitally. Along with an improved efficiency of electronic components with durable life span.
FUNCTIONAL DIFFERENTIATION IN CRIMINAL CODE: THE ROLE OF PROSECUTORS AS CASE CONTROLLERS IN INDONESIAN LAW
Authors:   Faculty of Law. Lampung University, Bandar Lampung. Indonesia., Kurniawan Maroni Didik , Siswanto Heni ,   Faculty of Law. Lampung University, Bandar Lampung. Indonesia., Tisnanta H.S ,   Faculty of Law. Lampung University, Bandar Lampung. Indonesia.
Published: November 2022

The principle of functional differentiation adopted by the Criminal Procedure Code can potentially cause significant problems in the future, especially for the Prosecutors office, which will cause many free verdicts due to the loss of ammunition of evidence presented by the Public Prosecutor. By using normative and empirical legal research methods (combined), normative legal research is carried out using a statute approach, a historical approach, and a comparative approach. This paper will discuss the position of the Prosecutors Office as a dominus litis in the Criminal Procedure Code if combined with an integrated criminal justice system that contains the principle of functional differentiation. The position of the Prosecutors Office as the controller of the case (dominus litis) after the enactment of the Criminal Procedure Code cannot be fully applied in the investigation process. Because they cannot be directly involved in the investigation, as in the validity period of the HIR, it is necessary to build more open communication from the beginning of the investigation. It will be perfect if it is built continuously by eliminating the sectoral egos of each institution.