bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving students’ reading comprehension through visualization strategy
Authors:   Universitas Lampung, Yasa I Gede Sandi , Yufrizal Heri ,   Universitas Lampung, Nurdiana Novita ,   Universitas Lampung
Published: July 2022

This research was aimed to improve students' reading comprehension ability through the visualization strategy, and also to investigate students’ perception toward the use of the visualization strategy. The subjects were 30 students of class VIII at SMPN 1 Seputih Raman. One group pre-test and post-test designs were used in this research. The instruments used in this research were reading comprehension tests (pre-and post-test) and questionnaires. The result of this research showed that the student's average progress score from pre-test was 52.37 and became 70,67 in post-test. After that, the Paired Sample t-test confirmed the hypothesis proposed by the researcher that there were significant differences in students' reading comprehension ability at the p<0.05, p = .000. The results of the questionnaire to answer the second research question showed that most of the students' perceptions above 70% were in the high category. Therefore, based on the result, it is concluded the student’s perceptions toward the use of visualization strategy were classified as a positive perception.
THE IMPACT OF COMPUTERIZED EXAM FEATURES, EFFECTIVE EXAM IMPLEMENTATION, TOWARD STUDENT SATISFACTION
Authors: Hendro Indra , Wiley Victor , Lucas Thomas
Published: July 2022

This paper intends to examine in detail the relationship between computerized exam features and effective exam implementation toward student satisfaction. The main goal is to examine the synergistic relationships which impacting student satisfaction after they using a computerized standardization exam in the college setting. Design/methodology/approach –an initial exploratory analysis was conducted methodically to confirm the proposed model through a structural equation modeling approach. The computerized exam features (especially, clear wording instruction and exam rulebook) had high effects on student satisfaction. Secondly, Effective Exam implementation (especially, efficient effort, time and cost) also impacted student satisfaction. Thirdly, the statistical testing result confirmed a joint impact of computerized exam features and effective exam implementation toward student satisfaction. The conceptual model has been validated to understand the role of both variables toward student satisfaction. However, there is lack of empirical validation and generalization of the model into wider scope due to limited time of research and a small number of the participant which suggest future research.
SEARCHING FOR ESP TEACHING MODELS TO MATCH THE TEXT-BASED INSTRUCTION FOR SENIOR SECONDARY VOCATIONAL SCHOOLS
Authors: Hidayatulloh Sibakhul Milad Malik
Published: July 2022

Students at vocational high school are expected to have proper English proficiency along with their vocational skill. However, Indonesian government has already set the teaching model to be Text-based Instruction (TBI) which is same with senior high school. As a result, English lesson for vocational school indicated as less purposeful. Therefore, this paper is intended to design appropriate teaching model in ESP to be integrated with the teaching cycle in TBI. By reviewing underlaying theories from TBI, and Teaching model in ESP, this paper proposed two teaching model combined with TBI. The first integration is integrating TBI with the practices of Flipped Learning Model in which the activities are divided into two phases namely before classroom time and inside classroom time. The second integration is integrating TBI with the phases of Project Based Learning in which the activities will be divided into four phases. The two proposed teaching model will be useful for promoting writing activities for students. Finally, by proposing those teaching models, it is expected that the practice of English lesson in vocational school will meet its objectives.
Some aspects of the methodology for studying the effectiveness of continuing medical education
Authors:   Federal State Autonomous Educational Institution of Higher Education ", Krasnopolskiy I. A. ,   Russian National Research Medical University named after N. I. Pirogov",   of the Ministry of Health of Russian Federation
Published: July 2022

The paper presents an analytical review of studies on the effectiveness of continuing medical education (CME). We examine various definitions of CME effectiveness, compare Kirkpatrick’s and Moore’s models in the context of CME effectiveness evaluation. We analyze studies on comparative effectiveness of different methods of medical specialists’ teaching, both traditional and high-tech.
Los retos del derecho en las sociedades abiertas e híbridas: el derecho en medio de la dinámica de la identidad y de las diferencias
Authors: Agudelo Ramírez Martín
Published: July 2022

"¿Qué es el hombre, si el principal bien y el interés de su vida consistieran tan sólo en dormir y comer? Una bestia, nada más. Seguramente. Aquel que nos ha creado como una inteligencia tan vasta que abarca lo pasado y el porvenir no nos dio tal facultad y la divina razón para que se enmoheciera en nosotros por falta de uso".
Racionalización formal del derecho moderno y justicia sustantiva.
Authors: Munné Guillermo J.
Published: July 2022

Entre los diversos aportes teóricos que hicieron de Max Weber una de las figuras principales del pensamiento social del siglo XX, encontramos su sociología del derecho que tiene como tema el proceso de racionalización del derecho occidental. Max Weber estudió ese proceso como una racionalización de tipo formal que es acompañada, aún en su última etapa moderna, de tendencias contrarias que se dirigen hacia la materialización del derecho. A partir de estos trabajos de Weber se ha construido una crítica del Estado social y una oposición a tomar los derechos sociales como derechos fundamentales, consistentes en afirmar que tal proyecto político conspira contra las notas de racionalidad del Estado de derecho por implicar la introducción de exigencias materiales de justicia que degradan la norma superior del ordenamiento jurídico, es decir, la Constitución.
El impacto institucional de la reelección
Authors: Estrada Villa José Armando
Published: July 2022

La reelección presidencial puede analizarse desde una doble perspectiva: la perspectiva personal o la institucional. Mirarla desde el ángulo del enfoque personal, le resta posibilidad al debate, por cuanto no puede desconocerse que el presidente Álvaro Uribe genera comportamientos pasionales entre seguidores y contradictores. U nos lo defienden con ardentía por sus logros en seguridad, y otros lo atacan con pasión por el escaso avance en las políticas de empleo y lucha contra la pobreza. Lo cierto es que por este camino, al final los argumentos se reducirían al amor o desamor que sienten los colombianos frente al primer mandatario.
Heidegger y su concepto de mundo
Authors: Estrada Villa Armando
Published: July 2022

Este artículo tiene el propósito de reflexionar sobre los conceptos de Dasein, tiempo y mundo en la construcción filosófica de Martín Heidegger. Para ello, el autor propone considerar que Dasein es el mismo ser humano que pregunta y responde por el ser, que puede transformarse y desplegar todas sus posibilidades y que debe estar abierto a sí mismo, al mundo y a los demás. Al tiempo lo mira como un elemento integrante de la existencia humana, en el que se producen los acontecimientos y constituye horizonte para toda la comprensión del ser, y que puede estudiarse como tiempo de la vida cotidiana, de la naturaleza y del mundo. En tanto que al mundo lo entiende como aquello que preexiste al ser, de lo que somos inseparables y que de alguna manera determina nuestra existencia porque estamos inmersos en su dinámica y en sus problemas.  Este escrito concluye que el enfoque de Heidegger es sobre la existencia humana y que con base en estos conceptos ofrece una mirada práctica que lleva al hombre a la autorreflexión, a la autocomprensión, lo que le permite construir su proyecto de vida y alcanzar la autenticidad.
Exploration of Indonesian Plants as Skin Lightening against Tyrosinase: A Virtual Screening
Authors: Hariyono Pandu , Karamoy Jasson Rhinehard , Hariono Maywan
Published: July 2022

Aesthetic is nowadays becoming as one of the important things for people to increase self-confidence. Flawless skin could be one of the desired looks especially for females which is a valuable cosmetics market. Skin browning is often associated with dermatological problems which may lead to hyperpigmentation due to the increase of the melanin biosynthesis. Skin browning could be caused by the overproduction of melanin which is accelerated by the presence of human tyrosinase. Therefore, the inhibition of this kind of enzyme is associated with skin lightening. In this present study, we perform in silico virtual screening against human tyrosinase by utilizing a natural product database from Indonesia Herbal Database (http://herbaldb.farmasi.ui.ac.id/v3/) to select 20 hit compounds. The simulation was carried using AutoDock Vina via molecular docking. The result shows that from 200 compounds of the database, those hits have a free energy of binding range from -12.1 to -9.2 kcal/mol predicting the affinity of the corresponding compounds towards human tyrosinase associating with its potential as a skin whitening agent. The hits correspond to their presence in Indonesian local plant that could be potential as resources for skin whitening.Keywords: Indonesian plant, molecular docking, skin lightening, tyrosinase, virtual screening.
In Silico Study of Thioguanine Derivatives as Hemopexin Matrix Metalloproteinase9 (PEX-9) Inhibitors
Authors: Putra Kevin Cahaya , Nugroho Ervan Setyo , Wisnumurti Yohanes Krisna , Dewa Sangga Putra , Putra Jati Benedictus Wisnu , Tiara Reynaldo , Setyaningsih Dewi , Hariono Maywan
Published: July 2022

Matrix Metalloproteinase (MMP) was broadly studied as one of the protein targets in stopping angiogenesis. The most common target in MMP, i.e., the catalytic site, is reported as being the non-selective target for inhibition amongst all MMPs, but its inhibition is associated with adverse side effects. Hemopexin in MMP9 (PEX9) was found to be different to the other domains in the MMP family, which could be the next target for anticancer due to the availability of its crystal structure in the protein data bank (pdb). In this study, we design the analogues of a compound from the ZINC database bearing a pyrimidinone scaffold which previously showed activity as a PEX9 inhibitor using molecular docking. The docking is carried out using Autodock 4.0 with parameters such as 250 run and lammarckian genetic algorithm. The result shows that six designed compounds have a free energy of binding from -7.0 to -11.0 kcal/mol. The important amino acid residues which are involved in the hydrogen bond interaction are ARG106, GLU60, GLU14, and GLN154. In conclusion, the six design compounds could give an insight mechanism to inhibit the PEX-9 activity in silico.Keywords: Docking, Hemopexin, MMP9, PEX9, Thioguanine
Case report: early class III correction using titanium dental implants and facemask therapy: a 24-year follow-up
Authors: Khan Nida , Stamatis John , Bower Robert , Henry Patrick J. , Goonewardene Mithran
Published: July 2022

The management of a Class III malocclusion in the mixed dentition presents with many challenges, in particular, the post-treatment growth-related changes which can continue into adulthood. This case report describes the multidisciplinary management of a 9-year-old female using titanium dental implants, rapid maxillary expansion and a Delaire facemask. Pre-treatment, post-treatment and long-term follow-up records of the patient are presented.
Molar uprighting using a newly designed segmental wire: a case report
Authors: Bae Seong-Min , Kim Ho-Jin
Published: July 2022

The ectopic eruption path of a permanent molar can cause incomplete emergence through interference by an adjacent tooth, early loss of a primary molar, or an arch length discrepancy. It is clinically important to determine the appropriate appliance that may easily be placed for the considered application of a molar corrective force. A newly designed appliance is introduced for the distal uprighting of an ectopically erupting molar and supported by two case presentations. The current technique of using a segmental wire incorporating double-sided hooks may easily and effectively resolve this problem.
Role of Government and Non-Governmental Organisations (NGOs) in Cyclone Recovery in Bangladesh
Authors: Nawaz Shahpara , Kabir Md. Humayain , Hossen Md. Nazmul
Published: July 2022

Immediate relief distribution activities are primarily focused on after a cyclonic event in Bangladesh, where proper long-term recovery and rehabilitation efforts are not strategized with much significance. This study concentrated on understanding and assessing the status and effectiveness of the post-cyclone recovery programmes to improve the lives of cyclone-affected households in southwestern Bangladesh. This study aims to examine the status and efficiency of Government and Non-government organisations (NGO) led cyclone recovery programmes for cyclone SIDR and cyclone AILA and identify the challenges that hindered the successful implementation of effective recovery programmes. The study reviewed existing literature on cyclone recovery in Bangladesh, including government and NGO reports, and conducted focus group discussions on cyclone-affected Dacope Upazila of Khulna. The finding indicates that the cyclone-affected community in southwestern Bangladesh has not recovered satisfactorily across all sectors and timescales from cyclone damages and continues to live in vulnerable conditions even after a decade of cyclonic events. The adopted recovery measures were not efficient and effective in returning to the everyday lifestyle of the affected people. Planned and coordinated recovery efforts should be executed with proper monitoring to ensure the effectiveness of post-cyclone recovery programmes.
Authors: Putri Penny Kurnia , Dharmiasih D.A Wiwik
Published: July 2022

Radikalisme baru-baru ini menjadi isu yang hangat dibicarakan, terutama dalam media massa. Sejak peristiwa penikaman terhadap mantan Menko Polhukam, Wiranto, yang terjadi pada 10 Oktober 2019 lalu, Mabes Polri seolah membunyikan kembali alarm kewaspadaan akan potensi munculnya bibit-bibit baru penebar teror yang sempat mati suri. Lingkungan universitas kemudian menjadi salah satu institusi pendidikan yang dianggap rentan terpapar persebaran ideologi tersebut. Penelitian ini bertujuan untuk mengetahui peta pemahaman mahasiswa di Bali terkait wacana radikalisme di Indonesia. Analisis dilakukan dengan metode kualitatif melalui kuesioner, diskusi kelompok dan wawancara terhadap mahasiswa di beberapa perguruan tinggi di Bali. Hasil penelitian menunjukkan bahwa pemahaman mahasiswa Bali terhadap konteks radikalisme di Indonesia adalah sangat tinggi (80%), namun kurang dalam memahami terminologi radikalisme secara keilmuan. Hanya sebagian kecil mahasiswa yang memiliki karakter kritis dalam merespon isu radikalisme dan menolak narasi tunggal. Selanjutnya, secara umum mahasiswa di Bali tidak berada dalam posisi rentan terpapar radikalisme meski terdapat pro dan kontra. Dalam ranah akademis, setiap tema isu layak untuk diperbincangkan selama tidak menyimpang dari konteks keilmuan.Pandangan kritis justru diperlukan sebagai sarana belajar, serta memahami isu dari sumber keilmuan yang sesungguhnya.
Federal Challenges in the Implementation of the EU’s Recovery and Resilience Facility in Germany
Authors: Scheller Henrik , Körner Anna Sophia
Published: July 2022

The paper focuses on the internal implementation process of the EU Recovery and Resilience Facility in Germany with special regard to the participation of the Länder in the development of the plan and its priorities. The course of the development and implementation process is exemplifying how the blindness of the EU and its treaties for federal systems can be used by national executives to pursue their objectives. The fact that the EU’s Recovery and Resilience Facility and NextGeneration EU were labeled by the EC as a “stimulus package” to combat the (short-term) consequences of Covid-19 made it easier for the German government to develop its own Recovery and Resilience Plan without major consultation. Concerning time constraints, there was no broader public discussion. Since the program and structure of the Recovery and Resilience Facility can also be interpreted as a new structural and cohesion policy approach of the EU, the lack of public discussion is of concern. Following this interpretation, a stronger involvement of the German Länder and municipalities in the negotiation process of the Recovery and Resilience Plan would have been indispensable. The analysis of the implementation of the EU’s Recovery and Resilience Facility in the Federal Republic intends to highlight exemplary aspects of multilevel governance that would need to be strengthened if the EU were to expand its range of economic policy instruments in the future.
Karin Geuijen, Paul ’t Hart, Sebastiaan Princen y Kutsal Yesilkagit: The New Eurocrats. National Civil Servants in EU Policy-making
Authors: Suárez Antón Orestes
Published: July 2022

Recensión del libro de Karin Geuijen, Paul ’t Hart, Sebastiaan Princen y Kutsal Yesilkagit, The New Eurocrats. National Civil Servants in EU Policy-making, Amsterdam University Press, 2008, 176 pp.
John Bachtler, Peter Berkowitz, Sally Hardy y Tatjana Muravska: EU Cohesion Policy. Reassessing performance and direction
Authors: Mangana Ríos Alicia
Published: July 2022

Recensión de la monografía de John Bachtler, Peter Berkowitz, Sally Hardy y Tatjana Muravska: EU Cohesion Policy. Reassessing performance and direction, Londres y Nueva York, Routledge, 2017, 345 pp.
Descentralización sanitaria, triunfo del nacionalismo y gestión de la COVID-19 en España
Authors: Velayos González Octavio , Martín Guardado Sergio
Published: July 2022

Este trabajo pretende abordar la conmoción provocada por la pandemia acaecida por el SARS-Cov-2, dada la afectación de la salud pública y, también, del Sistema Nacional de Salud. Es evidente que la COVID 19 marcará un antes y un después en la sanidad española, donde será necesaria una reorganización de esta en torno al Sistema Nacional de Salud. A través de la dotación de recursos, reformas en la gobernanza, la gestión y organización. La crisis de salud pública ha desbordado la capacidad del sistema sanitario debido, en gran parte, a sus carencias organizativas, así como de sus sistemas de información y, sobre todo, por una gobernanza carente de coordinación y cooperación sanitaria interautonómica. La inexistencia de un Sistema Nacional de Salud que reforzara el Ministerio de Sanidad y le otorgase solidez y capacidad de coordinación y cooperación, sí; pero también, la falta de una capacidad normativa que permita crear un sistema de información independiente, ajeno a los intereses autonómicos; han sido las principales causas. Con su creación, pretende aprenderse del error. A ello, puede unirse también la creación de reservas nacionales de carácter estratégico de material crítico, una red sólida de hospitales nacionales, con una clara estrategia en materia de investigación sanitaria. Una reorganización estatal permitiría una presencia mucho más activa y fuerte en el escenario mundial, especialmente en el marco de la OMS y en el Centro Europeo para la Prevención y el Control de las Enfermedades. Primará así la cooperación internacional y la diplomacia sanitaria que, a partir de esta tragedia, deberá plantearse como una parte de importancia estratégica capital para las relaciones exteriores. Este motivo ha llevado a dos constitucionalistas aun cuando se desconocen con exactitud las consecuencias catastróficas de la pandemia a plantear debates y propuestas sobre la descentralización de la sanidad y cuáles son los retos que habremos de abordar en un futuro muy próximo.
Antioxidant and anti-proliferative potential of Cardiospermum halicacabum stem extracts against human breast cancer (MCF-7) cells
Authors: Krithika N. , Chittibabu C. V. , Santhanapandi P. , Lenin M.
Published: July 2022

Cancer is the most important health care problem worldwide. An estimated 10 million new cases worldwide are recorded annually, of which 46% are in developed countries. Breast cancer is one of the second most common malignant tumors in the world. All forms of cancer treatment, including surgical treatment, chemotherapy and/or radiotherapy are often poor and often toxic to the normal cell. Therefore, there is still an urgent need for new cancer treatment options. More research is now being done to determine which compounds occur naturally. The current study aims to extract Cardiospermum halicacabum L. for the prevention and treatment of cancer. A few methods may account for the perceived therapeutic effects, most importantly direct cytotoxicity. These herbal medicines when combined with regular antioxidant and anticancer drugs may be helpful in combining the antioxidant and anticancer effects and reducing the side effects associated with common drugs.
Razones para promover la motivación en la Educación Superior
Authors: Ruiz Jose , García Muñoz Luis Héctor , Flores Barajas Silvana , De Santiago Barragán Antonio
Published: July 2022

En la actualidad se tienen programas especiales, desde niveles básicos hasta la educación superior, para desarrollar la creatividad en superdotados, en EEUU, UK y otros países. Sin embargo, de acuerdo a los expertos, todos somos creativos, pero debemos ser formados (o entrenados). Además, se sabe de la independencia de la creatividad con coeficientes intelectuales mayores a 120.

En un recorrido por las opiniones y teorías de creatividad de los especialistas en el tema, se sustenta lo arriba mencionado, para luego revisar las características que inciden en la creatividad. Se destaca la motivación, porque de manera natural ya se incluye (o se debe incluir) en la educación tradicional al menos en la educación superior.

A manera de verificación, se llevó a cabo un ejercicio para motivar a una muestra de conveniencia, valorando sus capacidades creativas antes y después, con el instrumento de valoración Torrance Tests of Creativity Thinking (TTCT) en su versión figurativa A (pre-test) y B (post-test).

Los resultados fueron muy concluyentes, confirmando lo expresado por los expertos, abriendo la posibilidad para todo estudiante promedio, de ser motivado para la creatividad en general, no para inventar o diseñar un producto patentable solamente, sino para ser creativo en cada tarea profesional que desarrolle, y que lo lleve a ser un gran emprendedor.

Además de las estrategias propuestas por algunos autores, está el ejercicio que se realizó, que comprende 15 horas presenciales y otras tantas por parte de los involucrados. Se añade también un esquema de motivación, muy utilizado por universidades privadas, y que no hay limitante que impida incorporarlo en la educación pública.
Satisfacción con la vida en universitarios del sur de México
Authors: Ocaña Zúñiga Jesús , García Lara Germán Alejandro , Cruz Pérez Oscar , Pérez Jiménez Carlos Eduardo
Published: July 2022

La satisfacción con la vida se puede definir como juicio cognitivo que las personas hacen de su vida con perspectiva espacio-temporal. Medir la satisfacción con la vida puede ser particularmente útil para evaluar el desarrollo social, identificar condiciones necesarias para el bienestar e incluso para orientar el diseño de estrategias preventivas de la salud mental o problemáticas psicosociales. Por ello, es pertinente su estudio con universitarios, debido a que en esta etapa los jóvenes son vulnerables pues se encuentran en el transitando de la adolescencia hacia la adultez, lo que implica una nueva carga de responsabilidades consigo mismo y con su proyecto de vida. En este contexto este trabajo tiene por objetivo medir la satisfacción con la vida de estudiantes universitarios del sur de México y  los posibles efectos que las variables Sexo, Lengua originaria y Carrera puedan tener sobre ella. Para ello se recuperó una muestra de 1,278 participantes, a quienes se les aplicó la escala de satisfacción con la vida de Diener (1985), en su versión traducida al castellano de 5 ítems. Los resultados apuntan a que los participantes tienen una alta satisfacción con la vida, con diferencias significativas por Lengua Originaria y Carrera, no así para Sexo.  Estos resultados cobran notoriedad en el contexto pues Chiapas, demarcación del sur de México, es una entidad culturalmente diversa con altos índices de rezago social y bajos indicadores de desarrollo humano.
ГЕОГРАФІЧНА СТРУКТУРА ФЛОРИ ЗАКАРПАТСЬКОЇ РІВНИНИ
Authors: Pryhara O. V.
Published: July 2022

The geographical analysis of flora vascular plants of the Transcarpathian plain has been carried out. It has been found that in the geographical distribution the species of flora belong to 16 types of areas. In the geographical range of flora the leading position is occupied by Golarctic (131), Eurasian (426), Eurasian-Mediterranean (138), and European (144) types of habitats. The presence of the autochthonous Transcarpathian and Pannonian flora core, including endemic and sub-endemic species was idfentified, its wide geographical connection with the flora of the Pannonia, the Mediterranean has been shown.
ПРОДУКТИВНІ ЯКОСТІ ГІБРИДІВ РІПАКУ ОЗИМОГО (BRASSICA NAPUS L.)
Authors: Humeniuk H. B. , Khomenchuk V. O. , Matsiuk O. B. , Yavorivskyi R. L. , Sodomora M. M. , Drobyk N. M.
Published: July 2022

The content of monosaccharides in flower nectar, nectar productivity, as well as the viability of pollen of hybrids Brassica napus L. Kuga, Dk Expression, Emerald (Smaragd) and Abacus were studied.

It was found that during the first and second pollen crops the most intensive germination of pollen grains occurred in Emerald (Smarahd) (75 % and 87 %, respectively), and Kuha (80 % and 90 %, respectively) hybrids. In crops of other studied hybrids - Dekalb Expression, Abacus, PT 264 - inhomogeneous pollen grains of different sizes were observed, the percentage of pollen germination was lower. It was found that the average number of monosaccharides is much higher in hybrids Abacus and Kuha (27.5 and 36 mg / 30 flowers, respectively). Kuha (156.8 kg) and Emerald (Smaragd) (81.4 kg) hybrids have the highest nectar fertility. Analysis of monosaccharides content in flower nectar, nectar fertility and pollen viability, as well as the correlation of these indicators allows to predict in the future among the studied hybrids higher productivity of hybrids Kuha and Emerald (Smaragd).
ОСНОВНІ ПІДХОДИ ДО ОЦІНЮВАННЯ СТІЙКОСТІ ВОДНИХ ЕКОСИСТЕМ
Authors: Sukhodolska I. L. , Grubinko V. V.
Published: July 2022

The study presents a generalization of the approaches to the assessment of ecosystems stability and fragility. The paper demonstrates the significant components that characterize the violation of water ecosystem stability and are presented with the change of abiotic and biotic indicators. The author defines stability according to the indexes that characterize indicators of salt composition, trophic and saprobe biological composition and toxic effect, environmental impact, ecological capacity, technical capacity, ecological reserves, effectiveness of the mechanism of constructive metabolism of chemical compounds, population carrying capacity, population capacity, trophic status, coefficient of water self-restoring, comparing the indicators with statutory meanings, complex biocoenotic criteria, and levels of compensation mechanism of water biotic self-regulation as well. Provided that the natural variability amplitude of hydrobionts is presented with supersensitive indicators, they depict the state of balance and ecosystems violations. Biota’s reaction is revealed with the changes of species wealth, species number, biomass, net primary production, succession phases (series) of grouping, morphogenesis, ontogenesis, vitality, structure, correlations with strategy types (S/R), interspecies relations etc. The use of integral approaches that include the range of stated indicators enables to develop equal ecosystem loads, identify or model biota’s reaction according to this influence and define relative stability of water objects.
TECHNOLOGIES OF TEACHING TO IDENTIFY FAKES IN THE “INFOMEDIA LITERACY” COURSE
Authors: KUSHNIR OKSANA , RESHETUKHA TETIANA
Published: July 2022

Today, in the conditions of increased information pressure, the need for critical perception of media messages has become acute. Media literacy skills should become the basic competencies of every person. In this context, the significance of the course “Information Media Literacy” is growing as its aim is to develop in students ability to thoughtfully perceive media materials and critically interpret them, including identification of fakes and manipulations. The Russian-Ukrainian war provoked a quantitative increase in the deliberate spread of misinformation, which includes fakes. Their spread is extremely dangerous. False messages can be used to manipulate peopleʼs minds and cause interpersonal and global conflicts. The purpose of the publication is to substantiate the need and provide technologies for the development of skills to identify fake messages while studying the course “Information Media Literacy”. To achieve this goal, the following methods have been used: descriptive (classification, document analysis), media linguistic (rhetorical, cognitive, discursive analysis of media texts), content monitoring, content analysis.

The research findings revealed that awareness of the need to include media literacy in the educational process dates back to the 60s of the twentieth century, and its main objectives were formulated by UNESCO in 2007. In 2010, the Concept of Implementing Media Education in the educational process was adopted in Ukraine. The discipline “Information Media Literacy” became the basis for its implementation in TNPU, which involves the development of studentsʼ relevant media and cultural competencies. The formation of critical immunity of the media audience is based on the algorithm of identification of fake information. The study of fake markers was the subject of practical educational technologies tested in the educational process of TNPU. The proposed tasks are designed to develop skills for recognizing signs of fakeness in the information space. Each task provides methodical tools: the purpose, program competencies and learning outcomes, the order of performing and options for justification of answers. In particular, the tasks involved developing skills to work with sources of information; ask questions, justify oneʼs own point of view; evaluate and interpret events; identify fakes, propaganda and manipulation tools in texts and headlines. Tasks are aimed at achieving the following learning outcomes by students: the ability to demonstrate the appropriate level of critical thinking and understanding of the level of information impact on the individual; ability to interpret current phenomena (fake news, information attacks, manipulation, etc.) of the information space for a wide audience, to increase the level of its media literacy.
CONTENT-LANGUAGE INTEGRATED LEARNING IN THE CONTEXT OF EUROPEAN INTEGRATION
Authors: LEVCHYK IRYNA
Published: July 2022

The conditions of formation of content-language integrated learning (CLIL) have been characterized with a number of theoretical and methodological factors, that have influenced the process of development from different perspectives. The origin of CLIL is connected with the prior methodological approach to second language acquisition – content based language instruction. It has been established with aim to reduce the gap in knowledge of English learners between spoken everyday English and Academic language. The reflection of the psycholinguistic views in CBI led to adoption of concepts of comprehensive output, input hypothesis and proximal zone of development in its subsidiary method (CLIL). Besides this, another methodology affecting formation of content-language integrated learning, known as “English for special purposes”, is also contextualized by specialty content, and they share common goals of learning. However, ESP keeps its focus on language, not content. The comparative analysis of CBI and ESP key features reveals the theoretical and methodological conditions of CLIL formation.

The modified variations of CLIL approach, applied all over Europe like Bilingual Content Teaching, Bilingual Subject Teaching or Content-Based Language Teaching, relied on a common concept of learning a foreign language with a shift of focus from the language itself to the content expressed in this language. The bilingual model of education in European countries adopted the provisions of content-language integrated learning methods at the mainstream level in school education in France, Ireland, Finland, Estonia, Latvia, Poland, the Czech Republic, and it has been partially implemented within pilot projects in the UK, Spain, Germany, Italy and Sweden. The method was strongly supported by policy of the European Union and European Commission with an aim of promotion of language learning and linguistic diversity. The support of the European language policy and ideology was reflected in a number of projects launched in order to promote methods based on international cooperation, such as “Content and Language Integrated Learning in Germany” (CLILiG), as well as with the support of the Council of Europe “CLIL Quality Matrix” (2004) and the European Regional Action Scheme for the Mobility of University Students (ERASMUS).
THE PECULIARITIES OF PREPARATION OF A TEACHER-PHILOLOGIST BY MEANS OF THE ELECTIVE COGNITIVE LINGUISTIC COURSES
Authors: VILCHYNSKA TETIANA , BACHYNSKA HALYNA , VERBOVETSKA OKSANA
Published: July 2022

The article is devoted to the problem of training a teacher of Philology by means of elective cognitive linguistic courses. On the one hand, the penetration of cognitivism in various fields of humanities, the urgent need to create a new understanding of the role of languages in the processes of cognition and comprehension of the world, the essence and functioning of the mental lexicon, including proper names, and deep relationships between history and culture, on the other hand, not less critical need for specialists ready to work in the new Ukrainian school, able to understand languages in cognitive processes, to implement a socio-cultural approach to language and speech material, determine the relevance of the proposed topic. Except for this, we also considered that nowadays, the students’ training includes the curriculum with at least 25  % of credits for elective courses, which ensures the implementation of a student-centred approach to learning. The article aimed to find out the peculiarities of the training of a teacher-philologist in the study of such elective disciplines of the language cycle as “Cognitive Linguistics”, “Cognitive Onomastics” and “Ukrainian Ethnolinguistics in the Cognitive Dimension”. To achieve this goal, the example of studying individual topics has shown how to optimize the learning process. In particular, short theses on the mentioned topics, control questions, tasks for independent work and literature review are offered. The conclusion is made about the advantages of both lectures and practical training. If during the lectures, students should, first of all, master the terminology and master the theoretical knowledge, then at the workshops, they ought to acquire skills of conceptual analysis, learn to model and structure concepts, understand language as a creative product of ethnosociety, and proper names - as units of the mental lexicon. The observations allowed us to conclude that the study of these disciplines is of great theoretical and practical importance. Theoretical value includes the assimilation of linguistic information to understand the cognitive mechanisms and role of language in them, the processes of ethnogenesis, and the functioning of language units in the mental lexicon; the practical one lies in need to develop students’ skills to use knowledge in future teaching. In general, the study outlined several problems caused by the penetration of cognitivism in language, which require further in-depth analysis, especially in terms of Linguodidactics.
Dissipation of Hydraulic Energy in Stilling Basin by Cutting Baffle Blocks
Authors: Irzooki Raad H. , Bakir Abd-Alsabir I. , Kadhban Idan I.
Published: July 2022

This study was undertaken to evaluate the hydraulic performance of stilling basin with unusual shapes of baffle blocks. Seven groups of baffle blocks were selected for this purpose , these blocks were cut within a different forms, three of these groups were cut with angle (15º, 30º, 45º) horizontally. Another three groups were cut with the same above angles, but vertically. The seventh group was cut with semi-cylindrical section (shown from side view). For a comparison, standard trapezoidal baffle blocks were used.Dimensional analysis technique was used to obtain the dimensionless parameters of hydraulic performance of the cutting baffle blocks and the drag force applied on these blocks. Laboratory experiments were carried out on one raw of the cutting baffle blocks for each model. The results indicated that the cutting baffle blocks are generally better than the standard blocks in dissipation of a hydraulic energy and reduction of a hydraulic jump length, but a ratio of drag force applied on cutting baffle blocks was greater than this ratio on the standard blocks. For the same flow conditions and angle of cut, the baffle blocks of vertically cutting gave a better results for energy dissipation and reduction in the length of the hydraulic jump than the baffle blocks of horizontally cutting, but the drag force applied on the baffle blocks with a vertically cutting was greater than applied on a blocks with horizontally cutting. Also, the results indicated that an agreement in the hydraulic performance between the baffle blocks which were cut at (45º) vertically and the baffle blocks of semi-cylindrical cutting. The cutting baffle blocks gives a greater value of the energy dissipation which was (80.62%) than the standard blocks and greater value of reduction in the hydraulic jump length which was(37.5%),also these blocks gives maximum increase of the drag force ratio which was (97%) greater than its value on the standard baffle blocks.
From the theater of improvisation to the creation of plays: ways of the emergence of dramatic text in Malay literature
Authors: Kukushkina Evgeniya
Published: July 2022

The subject of the research in the article is the process of the origin of the national drama of Malaysia. The object of the research is information on the history of the Malay and Indonesian city theater and works of Malay literature of the first half of the twentieth century. The author examines in detail the long-term changes that took place in the Malay theatrical tradition and the factors that contributed to the emergence of written dramatic texts.The purpose of the study is to determine the mechanism of transition from the unscripted theatrical tradition to dramaturgy. Particular attention is paid to the changes in the repertoire of the Malay city theater associated with the emergence of a new type of plots. The ways of their penetration into the representations of the city theater are analyzed, their influence on the nature of performances is considered. The emergence of a dramatic text in the theatrical tradition of British Malaya has not yet been studied either in domestic Malaistics or abroad, which determines the novelty of the work. The study uses an integrated approach combining the consideration of data on theater and literature. The cultural-historical method fits the available data into the context of the epoch. The comparative method allows us to determine the results of contacts between related theatrical phenomena of the Malay world (Bangsawan theater and the Istanbul Comedy Theater). The birth of drama is seen as a transition from the existence of unscripted spectacles to the creation of plays. As a theoretical basis for the analysis, the concepts of transitivity are used, which make it possible to present this phenomenon taking into account national specifics. This is the definition of a transitional aesthetic phenomenon as an artistic presystem, introduced by A.V. Lukov, as well as the structural gradation of the literary transition, presented in the work of A. A. Stepanova on the basis of generalization of a number of previously proposed approaches. As a result of the research, the main factor that contributed to the birth of Malay drama is revealed – the appearance of realistic plots in the repertoire of the previously unscripted theater of the transitional type. According to the findings of the study, there were two sources of these plots: external borrowings and the interaction of theater with literature.
To the Historiosophical Searches of the Late Gumilev: the Conflict of the Old and New World Order in the "Zvezdnyi uzhas" ["Star Horror"]
Authors: Pavlova Tatiana , Kikhnei Lyubov' Gennad'evna , Kuptsova Mariya Yur'evna
Published: July 2022

The subject of the study is N.S. Gumilev's poem "Zvezdnyi uzhas" ["Star Horror"] - one of the poet's last works, which has ambivalent semantics and contains the potential of polyvalent interpretation. The object of the study is the conflict of the poem "Zvezdnyi uzhas", which has a historical meaning and casts light on the conflicts of the distant past. On the other hand, through the plot of the poem, the realities of the present and its perception by contemporaries at the junction of epochs are read. The authors consider in detail such aspects of the topic as the identification of the tribe to which the main characters of the poem belong as a conflict-causing factor, the implicature of the conflict is also considered in the context of the collection "Ognennyi stolp" ["Pillar of Fire"]. Particular attention is paid to the conflict with the Zend tribe mentioned in the text, which is considered in the categories of the opposition of the true and imaginary, and the ambivalence of the conflict and the plot is also highlighted. The main conclusions of the study are various ways of reading the main conflict of the poem: the conflict of the old and the new, tradition and change, fathers and children; the poem also presents the conflict of various religious movements. A special contribution of the authors to the study of the topic is the possibility of reading this poem in the categories of various types of conflict, including the conflict associated with N.S. Gumilev's fascination with Zoroastrianism. The novelty of the research lies in the fact that for the first time the connection of the text of "Star Horror" with Zoroastrianism and ancient Persian traditions and motifs is shown. N.S. Gumilev consciously turned to Zoroastrian mythology not only in his early but also in his late work, and "Star Horror" in this respect has multiple interpretations of the plot and conflict. The question of attribution of the tribe, which is the main character of the text, is raised in connection with the mention of specific realities, the name of the tribe "Zend" indicated in the text is analyzed against the background of N.S. Gumilev's interest in the Persian theme in later poems.
Philosophical Traditions of Russian Regions: Past, Present, Future (MATERIALS OF THE ROUND TABLE)
Authors: Yarkova Elena Nikolaevna , Chernikova Irina Vasil'evna , Diev Vladimir Serafimovich , Zaks Lev Abramovich , Kudashov Vyacheslav Ivanovich , Dyagileva Tat'yana Vladimirovna , Mikhailov Ivan Sergeevich
Published: July 2022

The article is a summary of the contents of the round table held in April this year. Topic of discussion: philosophical traditions of Russian regions. Different points of view are presented regarding the understanding of the phenomenon of the philosophical traditions of the regions of Russia, its essence and various aspects of existence. An attempt is made to reconstruct the history of the formation of philosophical traditions in such regions of Russia as Tomsk, Novosibirsk, Krasnoyarsk, Yekaterinburg, Tyumen. The problem of correlation between the philosophical traditions of the regions of Russia and such phenomena in science as "scientific provincialism", "native science" is discussed. The speakers distance themselves from unambiguously apologetic or critical approaches to the study of the philosophical traditions of the regions of Russia, cultivating an analytical approach. The factors that influenced the formation of philosophical traditions in these regions are revealed: the presence in the region of ascetic philosophers with a charismatic gift to inspire young people with a love of philosophy, interest in a particular direction of philosophizing (logic and methodology of science, aesthetics, ethics); the presence of natural science or socio-humanitarian schools, within which the desire for philosophical understanding of concrete scientific problems; formation of a certain regional and all-Russian socio–cultural situation, which becomes a trigger for the development of philosophical traditions of Russian regions; cultivation of diversity of intellectual life, rejection of intellectual authoritarianism and transition to intellectual pluralism; development of the system of higher university education - the emergence of a philosophical faculty, the formation of a philosophical community, the formation of a philosophical cultural environment. The novelty of the project proposed to the reader lies in the fact that almost for the first time an attempt has been made to represent several regional philosophical traditions at once, which makes it possible to identify their common and special essential characteristics. In conclusion, it is stated that understanding the ways of development of philosophical knowledge in Russia is a difficult but important task.
A rare case of Exon 19 deletion transforming to Exon 20 insertion in a case of adenocarcinoma of lung
Authors: Harikrishnan S. , Darling H. S. , Sud Rahul
Published: July 2022

Epidermal growth factor receptor (EGFR) gene mutations play an important role in the presentation, prognosis, and management of non-small cell lung cancer (NSCLC) patients. Several clinical studies claimed the incidence of EGFR Exon 20 insertion mutations in NSCLC and have similar clinical characteristics to those with common EGFR mutations but poorer prognosis. Insertion mutations within the Exon 20 of the EGFR gene are typically located after the C-helix of the tyrosine kinase to result in the domain of EGFR and have been reported to increase the kinase activity of the protein. This eventually leads to the ligand-independent activation of several downstream pathways such as mitogen activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (Pi3K)-(mTOR) mammalian target of rapamycin pathways, which are involved in several cellular processes such as cell proliferation, metastasis, and migration while preventing apoptosis. Thus, EGFR exon insertion mutations are gain of function mutations. Specific EGFR and frame-in insertions occur in 3–7% of NSCLC and are known to predict primary resistance to treatment with all clinically available EGFR-tyrosine kinase inhibitors (TKIs). Many clinical and preclinical studies have reported significant antitumor activity with various first and second-generation EGFR TKIs such as Erlotinib, Gefitinib, and Afatinib and have led to prolonged survival in EGFR mutated patients, as compared to wild-type EGFR tumors with chemotherapy. In addition, third-generation EGFR TKIs, such as Osimertinib, have shown encouraging results in metastatic NSCLC patients harboring EGFR mutations including EGFR, p. Thr790Met-mutations, that have shown to confer resistance to first and second-generation EGFR TKIs and who have progressed on prior TKI therapy. Drugs such as Afatinib, Dacomitinib, Erlotinib, Gefitinib, and Osimertinib have already gained FDA approval for use in EGFR-mutated metastatic NSCLC patients. Here, we report the case of a 47-year-old man who is a non-smoker with an EGFR Exon 19 positive NSCLC treated with Gefitinib developed an EGFR Exon 20 insertion positive brain metastasis initiated on Afatinib as the targeted therapy and responded well to the treatment.