bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of Mental Emotional Disorder Symptoms using SRQ-20 in Pregnant Women: A Case Example from South Sulawesi, Indonesia
Authors: Rachmat Muhammad , Wati Fira , Hasnaeni Hasnaeni , Manti Sabaria , Hasliani Andi , Hasnita Hasnita , Marbun Uliarta , Bellani Elvita , Virani Devintha , Ikhsan Muh. , Asrianti Tanti , Hidayat Muliati , Anwar Sitti Andriani
Published: May 2022

The maternal health condition in Indonesia still requires special attention in terms of prevention and management of mental-emotional disorders. Meanwhile, the Indonesia Basic Health Research in 2013 results show that the prevalence of mental-emotional disorder was approximately 6% in each of the different provinces. This study aims to detect the prevalence of mental-emotional disorders symptoms in pregnant women and examine the relations with age, education, occupation, number of children ownership, MUAC (Mid-Upper Arm Circumference), and blood pressure. This is an analytical observational study conducted using a cross-sectional design on pregnant women that participated in antenatal examination visits to health facilities. The location was 60 Private Delivery Centers, 244 Public Health Centers, and 259 Hospitals. The sampling site was carried out in three different places, which focused on three areas of South Sulawesi in Makassar, Maros, and Pangkep. The pregnant woman within the age range of 20-35 years shows 71,3% with a p-value=0,080 having mental-emotional disorder symptoms and 71,5% of mothers with less than two children predominantly experienced mental-emotional disorders symptoms with a p-value=0,078. Hence, it is important to address this issue because the mental and emotional problems in pregnant women can potentially lead to adverse effects, both for the women and the baby.
Resolution of the Working Meeting of Experts in “Dermatology”: Possibilities of systemic therapy of atopic dermatitis with selective immunosuppressants
Authors: Bakulev Andrey L. , Vishneva Elena A. , Elisyutina Olga G. , Ilyina Natalya I. , Karamova Arfenya E. , Kokhan Muza M. , Kubanov Alexey A. , Monakhov Konstantin N. , Namazova-Baranova Leyla S. , Novik Gennadiy A. , Olisova Olga Yu. , Revyakina Vera A. , Sokolovskiy Evgeny V. , Fedenko Elena S. , Khobeysh Marianna M.
Published: May 2022

On February 19, 2022, a working meeting of experts on the problem of atopic dermatitis was held in Moscow under the chairmanship of the Director of the State Scientific Center for Dermatovenereology and Cosmetology of the Ministry of Health of Russia, Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences A.A. Kubanov. Also in attendance was the Academician of the Russian Academy of Sciences, Chief Freelance Childrens Specialist in Preventive Medicine, Head of the Research Institute of Pediatrics and Childrens Health of the Central Clinical Hospital of the Russian Academy of Sciences of the Ministry of Science, and Higher Education of the Russian Federation, Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, L.S. Namazova-Baranova, and also the Deputy Director for Clinical Work ― Chief Physician of the Federal State Budgetary Institution SSC Institute of Immunology FMBA of Russia Doctor of Medical Sciences, Professor N.I. Ilyina.
The meeting raised germane issues of providing medical care, reducing the burden of the disease, and improving the quality of life of patients with atopic dermatitis. New possibilities and principles of systemic therapy in patients with moderate and severe atopic dermatitis were discussed. We analyzed data on a new representative of the small molecule class the selective Janus kinase 1 inhibitor, upadacitinib, which was registered in the Russian Federation in June 2021. This analysis aimed to determine its place in atopic dermatitis therapy algorithms and the possibility of the impact of its use as a therapy on the quality of life of patients in relation to the burden of diseases.
The article has been published in several journals simultaneously with permission from authors and publishers. The parallel publication is available here: Capabilities of atopic dermatitis systemic therapy with selective immunosuppressors: resolution of the experts workshop of dermatology profile. Pediatric pharmacology. 2022;19(2):209211. DOI: https://doi.org/10.15690/pf.v19i2.2424
Kaji Eksperimental Perbandingan Penggunaan Bahan Bakar pada Mesin Parut Kelapa
Authors: Rijanto Achmad
Published: May 2022

Mesin parut kelapa banyak digunakan pada industri rumah tangga. Mesin ini dapat digunakan dengan bahan bakar bensin, atau gas atau keduanya. Tujuan dari penelitian ini adalah untuk mengetahui perbandingan penggunaan atau konsumsi bahan bakar bensin dan gas pada mesin parut kelapa. Bahan bakar bensin yang digunakan adalah pertalite dan bahan bakar gas yang digunakan Liquified Petroleum Gas (LPG) 3 kg. Metode yang digunakan dalam penelitian ini adalah metode eksperimental. Dari hasil penelitian, diperoleh bahwa besarnya konsumsi bahan bakar gas LPG pada putaran mesin 1.900 rpm sebesar 0,136 kg/jam - 0,152 kg/jam, sedangkan pada putaran yang sama bahan bakar bensin yang digunakan sebesar 0,216 kg/jam - 0,324 kg/jam.
Analisa Pengaruh Laju Korosi Plat Baja ST 40 dan Stainless Steel 304 terhadap Larutan Asam Sulfat
Authors: Santoso Kukuh Adi
Published: May 2022

Korosi merupakan penurunan kualitas suatu logam yang disebabkan oleh terjadinya reaksi elektrokimia antara logam dengan lingkungannya. Dalam penelitian ini material yang digunakan adalah plat baja karbon ST 40 dan stainless steel (SS) 304 pada media korosi asam sulfat 1 M selama 48 jam. Metode yang digunakan adalah metode weight loss. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh asam sulfat (H2SO4) terhadap laju korosi plat baja ST 40 dan stainless steel (SS) 304, dan Mengetahui perbedaan laju korosi antara kedua material tersebut. Hasil pengujian laju korosi yang dilakukan dengan waktu 72 jam, didapat nilai rata-rata 3,69 mm/y untuk plat baja karbon ST 40, dan 0,18 mm/y untuk plat stainless steel (SS) 304. Korosi yang terjadi pada plat baja karbon dan stainless steel adalah korosi merata (uniforrm attack) dan korosi sumuran (pitting corrosion).
Rancang Bangun Pompa Hidram (Hydraulic Ram Pump) dengan 3 Varian Tabung Udara untuk Model Sistem Irigasi Persawahan
Authors: Yuli Satria Didin Dwi , Kurniawan Suharto Eko
Published: May 2022

Letak sumber air yang lebih rendah dari tempat tinggal masyarakat  membuat masyarakat memerlukan pompa, tetapi pompa konvensional mempunyai kendala jika sumber air tersebut jauh dari sumber listrik dan bahan bakar. Pompa hidram adalah solusi dari permasalahan tersebut, karena pompa ini tidak memerlukan energi listrik maupun bahan bakar. Pompa hidram dapat bekerja selama 24 jam, biaya pembuatan dan perawatan relatif murah .

Penelitian ini dilakukan untuk mengetahui head outout terbesar pompa hidram PVC/Pipa Bekas 1 inci pada 3 variasi tabung udara dengan volume TU1 0,0009 mÂ³, TU2 0,0019mÂ³, TU3 0,0024 mÂ³.

Dalam penelitian ini dengan varian 3 tabung udara, TU 1 dengan volume tabung 0.0009 mÂ³ tinggi output 4 m diperoleh head head output terbanyak sebesar 0.75 bar dengan tinggi input 1 m, panjang langkah 9 mm dan berat beban katup limbah 150 gram. Untuk TU 2 dengan volume tabung 0,0019 mÂ³ tinggi output 4 m diperoleh head output terbanyak sebesar 0,85 bar dengan tinggi input 1 m, panjang langkah 9 mm dan berat beban katup limbah 150 gram. Sedangkan TU 3 dengan volume tabung 0,0024 mÂ³ tinggi output 4 m diperoleh head output terbanyak sebesar 1 bar dengan tinggi input 1 m, panjang langkah 9 mm dan berat beban katup limbah 150 gram.
Sentimen Analisis Untuk Mengukur Kepercayaan Masyarakat Terhadap Pengadaan Vaksin Covid-19 Berbasis Bernoulli Naive Bayes
Authors: Azizah Hanifatul , Rintyarna Bagus Setya , Cahyanto Triawan Adi
Published: May 2022

Penelitian ini berisi tentang analisis sentimen masyarakat Indonesia pada Twitter terhadap kebijakan pemerintah dalam menangani kasus pandemi covid-19. Penelitian ini menggunakan metode Bernoulli Naive Bayes dalam melakukan pemodelan dan pengujian klasifikasi terhadap data sentimen. Digunakan juga metode pengukuran performa akurasi, presisi dan recall untuk mengukur performa metode Bernoulli Naive Bayes. Pada pembagian dan skenario pengujian digunakan teknik K Fold Cross Validation dengan nilai k = 2, 4, 5, 8 dan 10. ketidakseimbangan data dalam penelitian ini diselesaikan dengan menggunakan teknik Synthetic Minority Oversampling Technique (SMOTE). Dari hasil pengujian dengan model tanpa menggunakan teknik Synthetic Minority Oversampling Technique (SMOTE) diperoleh hasil dengan tingkat akurasi sebesar 80.58%, tingkat presisi sebesar 80.33% dan tingkat recall sebesar 85.57%. sedangkan hasil pengujian dengan menggunakan teknik Synthetic Minority Oversampling Technique (SMOTE) pada pemodelan, diperoleh tingkat akurasi 80.20%, tingkat presisi 78.04% dan tingkat recall 86.77%.
Los pobres en una Iglesia sinodal
Authors: García Maestro Juan Pablo
Published: May 2022

El papa Francisco desde el inicio de su ministerio como Obispo de Roma ha pretendido valorar el Sínodo, que constituye una de las herencias más preciosas del Concilio Vaticano II. El Concilio y su herencia es parte del designio del Espíritu. Dudar del Concilio es dudar del propio Espíritu que guía a la Iglesia. Si la Iglesia sinodal exige caminar juntos, sin embargo, los más pobres deberán ser los primeros en nuestro caminar. Los pobres tienen mucho que enseñarnos. Es necesario que todos nos dejemos evangelizar por ellos. Jesús de Nazaret no sólo está de parte de los pobres, sino que comparte con ellos la misma suerte.
Impact of Entrepreneurial Orientation on Performance of Quoted Breweries in Nigeria
Authors: John Oluremi Oluwatosin , Nwoye May Ifeoma , Yayok Paul Kanwai
Published: May 2022

This empirical study investigated the impact of entrepreneurial orientation (OE) on organizational performance (OP) of quoted breweries in Nigeria considering the mediating effect of organizational embeddedness in the OE-OP relationship under the theoretical lens of the Resource Based (RBV) theory. The focus was on the five quoted breweries in Nigeria- Guinness Nigeria Plc, Nigeria Breweries Plc, Champions Breweries Plc, Golden Guinea Breweries Plc and International Breweries Plc. The study used survey design. Data were collected from 1,120 employees of the five quoted breweries through a questionnaire and analyzed by Partial Least Square - Structural Equation Modeling (Maximum Likelihood). The result showed a significant positive relationship between entrepreneurial orientation (risk-taking, innovativeness and proactiveness) and organizational performance (organizational effectiveness and employee satisfaction) and concluded that organizational embeddedness positively mediates the relationship between entrepreneurial orientation and organizational performance. The findings of this study provide organizational performance guidelines for management of the breweries. The research work considers the effect of the mediating role of organizational embeddedness in the entrepreneurial orientation – organizational performance relationship. This is a gap that has not been fully investigated in the literatures reviewed.
PENGARUH PENAMBAHAN EM4 PADA PENGOMPOSAN AMPAS KULIT LADA PUTIH (Piper nigrum, L) TERHADAP KANDUNGAN NPK
Authors: Nanda Lakaoni Larasati , Dewi Triastianti Rita , Muyasaroh Nurul , Nasirudin Nasirudin
Published: May 2022

Luwu Timur merupakan daerah produsen lada terbesar di provinsi sulawesi selatan. Dalam pengolahanlada, khususnya lada putih akan menghasilkan limbah berupa ampas kulit lada putih dari hasil rendaman selama 1minggu yang dapat mencemari lingkungan sekitar karena memiliki bau yang tidak sedap. Tujuan dari penelitianini adalah mengetahui pengaruh penambahan EM4 pada pengomposan ampas kulit lada putih (Piper nigrum, L)terhadap kandungan NPK. Metode penelitian yang digunakan dalam penelitian ini adalah Rancangan AcakLengkap (RAL) yaitu EM4 sebanyak 0 ml, 5 ml, 10 ml, 20 ml dan diulang sebanyak tiga kali. Variasi EM4tersebut diaplikasikan ke dalam ampas kulit lada putih yang kering dengan bantuan air yang dipercik sampaimerata dan larutan gula sebanyak 10.5 ml untuk dijadikan pupuk kompos. Pengomposan dilakukan selama 28 haridan mengamati fisik kompos yaitu suhu, warna, tekstur dan bau. Data yang diperoleh dari pengujian dianalisisstatistik menggunakan uji ANOVA (One way Anova) dan dilanjutkan uji BNT ( Beda Nyata Terkecil). Hasilpenelitian menunjukkan bahwa berdasar anova Î± 5% membuktikan bahwa EM4 berpengaruh nyata terhadap kadarkalium kompos ampas kulit lada putih (Piper nigrum, L). Uji BNT Î± 5% menunjukkan bahwa volume EM4sebanyak 5 ml merupakan perlakuan terbaik karena lebih efisien dari volume EM4 yang lain dengan hasil yangtidak berbeda nyata dengan volume EM4 sebanyak 10 ml dan 20 ml.
SIMULTANEOUS SOLAR PHOTO-DEGRADATION OF PVC-FE-DOPED ZNO-NANOCOMPOSITE FLAKES AND METHYLENE BLUE DYE IN WATER
Authors: Roy Anirban , Chakrabarti Sampa , Maitra Saikat
Published: May 2022

Simultaneous solar photocatalytic decolorization of Methlene Blue (MB) dye and degradation of polymer nanocomposite film in water has been attempted in the present work. The film immobilized iron (Fe)-doped zinc oxide (ZnO) nanoparticles (NPs) in polyvinyl chloride (PVC) matrix. This reduced the cost of separation of nanoparticles from treated water. Doped NPs were prepared sonochemically using zinc acetylacetonate (0.95 mmol) and ferric acetylacetonate (0.05 mmol) precursors in aqueous ethanol medium. XRD, UV-vis spectroscopy, FESEM and EDX were used for characterizing nanoparticles whereas the film was characterized by SEM. During the process, the film also reduced in weight. Degradation of both the dye and the polymer followed pseudo-first order kinetics. About 28% of the initial concentration of dye and about 5.04% of the initial weight of the PVC-film were decreased in the process after a run time of 3 h 45 minutes.
Compact Object Modeling in the Globular Cluster 47 Tucanae
Authors: Ye Claire S. , Kremer Kyle , Rodriguez Carl L. , Rui Nicholas Z. , Weatherford Newlin C. , Chatterjee Sourav , Fragione Giacomo , Rasio Frederic A.
Published: May 2022

The globular cluster 47 Tucanae (47 Tuc) is one of the most massive star clusters in the Milky Way and is exceptionally rich in exotic stellar populations. For several decades it has been a favorite target of observers, and yet it is computationally very challenging to model because of its large number of stars (N ≳ 106) and high density. Here we present detailed and self-consistent 47 Tuc models computed with the Cluster Monte Carlo code (CMC). The models include all relevant dynamical interactions coupled to stellar and binary evolution, and reproduce various observations, including the surface brightness and velocity dispersion profiles, pulsar accelerations, and numbers of compact objects. We show that the present properties of 47 Tuc are best reproduced by adopting an initial stellar mass function that is both bottom-heavy and top-light relative to standard assumptions (as in, e.g., Kroupa 2001), and an initial Elson profile (Elson et al. 1987) that is overfilling the cluster’s tidal radius. We include new prescriptions in CMC for the formation of binaries through giant star collisions and tidal captures, and we show that these mechanisms play a crucial role in the formation of neutron star binaries and millisecond pulsars in 47 Tuc; our best-fit model contains ∼50 millisecond pulsars, 70% of which are formed through giant collisions and tidal captures. Our models also suggest that 47 Tuc presently contains up to ∼200 stellar-mass black holes, ∼5 binary black holes, ∼15 low-mass X-ray binaries, and ∼300 cataclysmic variables.
z ∼ 2–9 Galaxies Magnified by the Hubble Frontier Field Clusters. I. Source Selection and Surface Density–Magnification Constraints from >2500 Galaxies
Authors: Bouwens R. J. , Illingworth G. , Ellis R. S. , Oesch P. , Paulino-Afonso A. , Ribeiro B. , Stefanon M.
Published: May 2022

We assemble a large comprehensive sample of 2534 z ∼ 2, 3, 4, 5, 6, 7, 8, and 9 galaxies lensed by the six clusters from the Hubble Frontier Fields (HFF) program. Making use of the availability of multiple independent magnification models for each of the HFF clusters and alternatively treating one of the models as the “truth,” we show that the median magnification factors from the v4 parametric models are typically reliable to values of 30–50, and in one case to 100. Using the median magnification factor from the latest v4 models, we estimate the UV luminosities of the 2534 lensed z ∼ 2–9 galaxies, finding sources as faint as −12.4 mag at z ∼ 3 and −12.9 mag at z ∼ 7. We explicitly demonstrate the power of the surface density–magnification relations Σ(z) versus μ in the HFF clusters to constrain both distant galaxy properties and cluster lensing properties. Based on the Σ(z) versus μ relations, we show that the median magnification estimates from existing public models must be reliable predictors of the true magnification μ to μ < 15 (95% confidence). We also use the observed Σ(z) versus μ relations to derive constraints on the evolution of the luminosity function faint-end slope from z ∼ 7 to z ∼ 2, showing that faint-end slope results can be consistent with blank-field studies if, and only if, the selection efficiency shows no strong dependence on the magnification factor μ. This can only be the case if very low-luminosity galaxies are very small, being unresolved in deep lensing probes.
The Entry of Supergiants into the Astronomical Lexicon
Authors: Smith Graeme H.
Published: May 2022

The early use of the term supergiant within the published literature has been traced from text searches carried out with the SAO/NASA Astrophysics Data System.
Needs of early-career professionals in STM: Findings from two surveys
Authors: Foley Erin , Moriarty Rachel , Martin Kerys
Published: May 2022

Background: The Early Career Publishers Committee (ECPC) of the STM Association (the International Association of Scientific, Technical, and Medical Publishers)’s Early Career Publishers Committee (ECPC) aims to engage, and provide tools and resources for, early-career publishers (ECPs) and professionals. The committee believes it is important to survey the community regularly to understand the background, needs, and concerns of its members to better achieve the committee’s goals.

Objectives: Early-career professionals were surveyed in 2014 and 2020: the first survey was undertaken to get a baseline understanding of the community and to guide the newly formed ECPC whereas the second not only sought to review some aspects of the first survey but also to identify and explore ways to improve engagement and support through new or revised survey questions.

Methods: The two surveys were conducted online through the ECPC mailing list and social networks. The surveys were voluntary, with the option to skip some questions, and responses – some in the form of a rating scale – were collected anonymously. Each survey remained open for over a month to maximize responses, but neither was pretested. Some questions in the first survey were revised in the second in the light of learnings from the first survey.

Results: Most of respondents were women, 25–54 years old, from the UK or the US, with higher degrees, and working in editorial roles. In the second survey, many respondents were interested in developing their career either in their current

role or in a different one, and nearly half were actively seeking a new role. Over half said that finding the right role was a challenge. Many had never participated in a publishing-related mentoring scheme, and most had not heard of the STM mentoring scheme before.

Conclusions: More tools, resources, and outreach for entry-level and younger industry members, for those from countries outside the UK and US, and for those seeking to develop their careers may be useful in the future. The mentoring scheme could be publicized more prominently to drive engagement. A new survey will be needed in the next 2–3 years, given the potential impact of the COVID-19 global pandemic on the number of respondents in the second (2020) survey and their motivation.
Description of a new species of leopard geckos, Eublepharis Gray, 1827 from Eastern Ghats, India with notes on Eublepharis hardwickii Gray, 1827
Authors: Mirza Zeeshan A. , Gnaneswar Chandrashekaruni
Published: May 2022

A recent molecular phylogenetic study of the genusEublepharisGray, 1827 revealed the presence of a genetically divergent lineage sister toEublepharis hardwickiiGray, 1827. We re-assessed the taxonomy ofEublepharis hardwickiibased on museum material in light of the molecular phylogenetic study and the results support the recognization of two species distributed on either sides of the Brahmani River. A redescription ofE. hardwickiiis presented based on the holotype and additional museum material along-with the description of a new species,Eublepharis pictussp. nov.from Andhra Pradesh and Odisha. The presence of yet another distinct lineage in such close geographical proximity in the northern Eastern Ghats highlights the significance of these relic forests and advocates the need for conservation prioritization.
Contribution des actes de la pratique à l’histoire du lignage chevaleresque d’Évrecy au Moyen Âge central (XI e -XIII e siècle)
Authors: Trân-Duc Lucile
Published: May 2022

Si Évrecy a retenu l’attention des historiens médiévistes jusqu’ici, c’est essentiellement pour le haut Moyen Âge. La période suivante n’a fait l’objet que de peu d’études. Pourtant, les actes de la pratique conservés aux Archives départementales du Calvados apportent de précieuses informations sur les xi e - xiii e  siècles. C’est ainsi qu’après avoir rappelé la position d’Évrecy au sein du duché de Normandie, entre évêques de Bayeux et comtes de Gloucester, le présent article s’intéresse à l’émergence progressive d’un lignage dit d’Évrecy à compter du xi e  siècle. Il s’agit plus particulièrement d’envisager le parcours des membres de cette topolignée en termes de mobilité sociale et d’étudier les stratégies mises en œuvre pour affirmer leur conscience élitaire et leur appartenance à l’aristocratie.
Creating a New Universe: The Story of the Crystal Discovered by the Duality of Light and Electron
Authors: JEONG Se-Young
Published: May 2022

The study of crystals is like the beginning of solid state physics. Crystallography was developed rapidly with the discovery of X-ray. Recently, the era of physics is enriching with the emergence of new material groups such as graphene, topological insulators, and TMD materials. In a way, it is very interesting to see that the providence of the universe and the philosophy of life are reflected in the small crystal structure. However, unfortunately, little is known about when and how crystal growth began. How did our ancestors in the beginning grow and study crystal? This article examines the history of early crystal growth, the development of crystallography, and the relationship between crystallography and physics.
La desprotección y desaparición del patrimonio industrial en las ciudades españolas: El caso de Burgos
Authors: López Gonzalo Andrés
Published: May 2022

Buena parte de las ciudades españolas atesora un interesante legado de la cultura industrial contemporánea que se encuentra en franca situación de vulnerabilidad. Pese a los notables avances habidos en las últimas décadas en la consideración del patrimonio industrial y su catalogación, son todavía muchos los espacios urbanos en los que encontramos un amplio conjunto de bienes sin protección cultural ni urbanística. Se trata de un legado olvidado, desprotegido y, en muchos casos, ya desaparecido o en proceso de desmantelamiento. Esta lamentable circunstancia es, si cabe, aún más llamativa en aquellas ciudades con un alto índice de actividad productiva, en las que la pérdida de este patrimonio cultural afecta severamente a su identidad urbana. Es el caso de Burgos, una ciudad industrial sin patrimonio. Se trata del décimo conjunto urbano del país en suelo industrial y el duodécimo en empleo manufacturero, si bien no se han conservado fábricas e instalaciones industriales que, al no valorarse y protegerse adecuadamente, se han ido degradando y desmantelando. Esta contribución identifica y analiza la desaparición de estos bienes, reflexiona sobre la historia y el significado del escaso legado que se mantiene y realiza un inventario de este patrimonio, constatando su desprotección
ROADMAP DE GESTÃO DE PORTFÓLIO: INTEGRANDO ESTRATÉGIA E ATIVOS DE CONHECIMENTO EM UMA ORGANIZAÇÃO PÚBLICA
Authors: Nadai Rafael , Silva Marcelo , Costa da Silva Marco Antonio , Figueiredo Jeovan
Published: May 2022

As Instituições de Ensino Superior que realizam atividades de pesquisa e desenvolvimento tecnológico são, por definição, organizações intensivas em conhecimento. São, assim, organizações complexas, com desafios relacionados à implementação da estratégia e ao elevado número de projetos para serem gerenciados. Frente a isso, o presente trabalho teve como objetivo propor um modelo de gestão de portfólio para projetos científicos e tecnológicos, no qual fossem integradas a estratégia e os ativos de conhecimento da organização. Por meio de uma pesquisa com características de pesquisa-ação, foi proposto um modelo de gestão de portfólio para um instituto de uma universidade pública. Os resultados da pesquisa-ação permitiram a formalização de informações organizacionais em um framework multinível, baseado em hierarquia de objetivos estratégicos e vínculo dos projetos e processos aos objetivos. Ativos de conhecimento também puderam ser identificados, e ainda, relacionados à execução dos projetos. Com a adoção do roadmap proposto, é esperado o aprimoramento da governança do portfólio de projetos, dado que o quadro proposto vincula a estratégia e a gestão do conhecimento na organização.
DEMOCRACIA E PARTICIPAÇÃO SOCIAL: FÓRUNS REGIONAIS DE GOVERNO DE MINAS GERAIS (2015-2018)
Authors: Resende Anelli Fernando , Duque Brasil Flávia de Paula
Published: May 2022

O objetivo deste trabalho é analisar aspectos relacionados à participação social no desenho e funcionamento dos Fóruns Regionais de Governo de Minas Gerais, concebidos como uma instituição participativa, no período 2015-2018. Contextualiza-se a experiência com a abordagem da arquitetura participativa criada e consolidada no Brasil, notadamente após a promulgação da Constituição Federal de 1988, destacando-se, contudo, a capacidade relativamente baixa de inovação democrática nesse âmbito por parte dos governos estaduais. A partir de uma breve revisão sobre democracia e participação social, construiu-se um modelo analítico com os seguintes aspectos: abertura dos espaços de decisão; origem das proposições; avaliação participativa; relação com outros processos participativos; e aprovação cidadã dos resultados. Em um balanço final, ainda que os Fóruns Regionais de Governo não tenham contemplado de maneira completamente satisfatória os aspectos analisados e tenham sido descontinuados, constituíram uma experiência relevante no avanço da democratização da gestão pública no estado de Minas Gerais.
MAPEAMENTO DE PROCESSO E ANÁLISE DE RISCOS DE FRAUDE NA DISPENSA DE LICITAÇÃO EM RAZÃO DA COVID-19
Authors: Hercules Augusto Edna , Puti Raquel , Silva Santos Alexandre , Tiradentes Terra Argoud Ana Rita
Published: May 2022

A pandemia COVID-19 desafiou a administração pública a ações rápidas. O presente artigo trata de uma delas: a dispensa de licitação prevista na lei 13.979/2020. O dispositivo foi importante para dar agilidade às compras públicas, mas também foi porta de entrada para fraudes. Nesse contexto, pergunta-se: as ferramentas de gestão por processos podem auxiliar na identificação de gargalos no processo de contratação direta por emergência? Quais prejuízos podem ser evitados? O objetivo deste trabalho é permitir melhor visualização do processo e dos riscos envolvidos em cada etapa desta dispensa de licitação usando ferramentas de gestão por processos e de gestão de riscos. Como cenário para análise foi selecionada a compra de respiradores no Rio de Janeiro. Trata-se de um estudo de caso com caráter descritivo-exploratório e de natureza qualitativa. Para tanto, para identificar gargalos e prevenir riscos, o trabalho apresenta o mapeamento da situação atual (as is) desse processo e o mapa de risco. Os resultados apontam que, embora a lei somente obrigue a realização de relatório de riscos depois de concluído o processo, é essencial que os gestores controlem esses riscos, à priori, para uma gestão rápida e eficiente.
In Situ Growth of Hydrophobic ZIF-8 on Poly(Aryl Ether Nitrile) as Low Dielectric Film
Authors: Wang Ling Ling , Liu Chen Chen , Liu Xiao Bo
Published: May 2022

Flexible polymers with excellent low dielectric constant stability are promising for application in the field of high-speed communications. In this work, a series of surface-modified ZIF-8 on polyarylene ether nitrile (PEN) as low dielectric films are prepared by phase inversion method. The experimental results show that by changing the content of Zn2+, the surface roughness, hydrophobicity, pore size, dielectric properties and mechanical properties of porous PEN films can be effectively adjusted. The surface roughness of porous PEN films effectively increases from 47.9 nm to 72.5 nm as the content of ZIF-8 grown in situ on porous PEN films surface increases. The static water contact angle of porous PEN films surface increases from 115° to 152°. The porosity of porous PEN films increases from 73.7% to 75.8% as the pore size of the fracture surface increases, and the dielectric constant decreases from 1.85 to 1.68 accordingly. Furthermore, the porous PEN films exhibit outstanding mechan ical flexibility, and the elongation at break of porous PEN films is as high as 89.6%. In-situ growth of ZIF-8 on PEN as low dielectric film expands the application of PEN in the field of high-speed communication.
In Silico Study on Predicting Effects of H243L Mutation in Bacillus subtilis Levansucrase towards Sucrose Binding Affinity
Authors: Sudijanto Jason Andrew , Hertadi Rukman
Published: May 2022

Levan is a branched polysaccharide made from fructose monomers linked by β (2-6) and β (2-1) glycosidic bonds. Levan biosynthesis is catalyzed with levansucrase (EC 2.4.1.10) using sucrose as its substrate. In the present study, we are interested in investigating the elongation capability of the polymerase domain of the enzyme. The other study on Bacillus subtilis levansucrase found that the mutation of His243 into Leu has successfully prolonged the elongation of the polymer. The study, however, has not clearly accounted for the effect of the mutation. The current study aimed to employ in silico method to reveal the effect of the mutation. The initial model of substrate binding on the wild-type and H243L mutant levansucrase was prepared by molecular docking. The stability of the substrate-binding was evaluated by molecular dynamics simulation, while the binding affinity was calculated by the MM-PBSA method. The result showed that the H243L mutant was more stable in binding the substrate than the wild type. This was supported by the calculated binding affinity for H243L mutant and wild-type, which were −2.9 and +4,8 kcal/mol, respectively. Further molecular analysis suggested that mutation of His243 into Leu made the nearby Glu340 and Arg246 form additional hydrogen bonds with the substrate.
Synthesis of Chalcone Derivatives from Halogenated Vanillin and their Activity Test as Antioxidant
Authors: Rijal Chairul , Haryadi Winarto , Anwar Chairil
Published: May 2022

Synthesis of 3-chloro-4-hydroxy-5-methoxybenzaldehyde, 3-bromo-4-hydroxy-5-methoxybenzaldehyde and 2',4'-dihydroxy-3-bromo-4-hydroxy-5-methoxyhalcone and evaluation of their antioxidant activity have been carried out. 3-Chloro-4-hydroxy-5-methoxybenzaldehyde was obtained through chlorination of vanillin using Ca(ClO)2, while 3-bromo-4-hydroxy-5-methoxybenzaldehyde was obtained via bromination of vanillin using KBrO3 in glacial acetic acid solvent and 47% HBr catalyst. Then, 2',4'-dihydroxy-3-bromo-4-hydroxy-5-methoxychalcone was prepared from 3-bromo-4-hydroxy-5-methoxybenzaldehyde and 2-4-dihydroxyacetophenone through Claisen-Schmidt condensation in the presence of KOH (40%) base and KSF montmorillonite in methanol. Elucidation of the structure of these compounds was performed using FTIR, GC-MS, TLC-Scanner, MS-Direct, 1H-NMR, and 13C-NMR. The synthesized benzaldehydes and chalcone were tested for their antioxidant activities using DPPH method, where 2,6-di-tert-butyl-4-methylphenol (BHT) was used as positive control. The results showed that 3-chloro-4-hydroxy-5-methoxybenzaldehyde, 3-bromo-4-hydroxy-5-methoxybenzaldehyde and 2',4'-dihydroxy-3-bromo-4-hydroxy-5-methoxyhalcone were obtained in 53%, 97%, and 1%, respectively. The antioxidant activity assay showed that BHT, 3-chloro-4-hydroxy-5-methoxybenzaldehyde, 3-bromo-4-hydroxy-5-methoxybenzaldehyde and 2',4'-dihydroxy-3-bromo-4-hydroxy-5-methoxyhalcone displayed the IC50 of 27.94, 244.11, 269.44 and 162.10 µg/mL, respectively.
Synthesis and Antimalarial Activity Assay of C- Arylcalix[4]pyrogallolarenes Using Heme Polymerization Inhibition Activity (HPIA) Method
Authors: Sari Diah Kartika , Hidayat Danny Danny Nur Wahyu , Fatmawati Dwi Rahmasari , Triono Sugeng , Kurniawan Yehezkiel Steven , Jumina Jumina
Published: May 2022

Malaria is one of the most devastating and widespread tropical parasitic diseases in developing countries with high prevalence. Furthermore, antimalarial drug resistance results in a global resurgence of malaria. Thus there is an urgent need to find new and active antimalarial agents. In this work, we reported the synthesis of C-arylcalix[4]pyrogallolarenes and their in vitro activity assay as new antimalarial agent candidates. The C-arylcalix[4]pyrogallolarenes were prepared in high yields through a condensation reaction between pyrogallol and aromatic aldehydes (i.e., benzaldehyde, 4-hydroxy-3-methoxybenzaldehyde, and 2-chlorobenzaldehyde) under acidic conditions. The antimalarial activity of C-arylcalix[4]pyrogallolarenes was tested using the Heme Polymerization Inhibition Activity (HPIA) method with chloroquine diphosphate as the positive control. The heme polymerization inhibitory activity was reflected from the IC50 values in which the IC50 values were obtained from probit analysis using IBM SPSS statistics 25 software. The result showed that the IC50 values of C-arycalix[4]pyrogallolarene derivatives were in a range of 0.238–1.268 mg/mL, which were lower than chloroquine diphosphate (IC50 = 2.788 mg/mL). This finding reveals that the C-arylcalix[4]pyrogallolarenes are potential antimalarial agents to be developed in the future.
Open Chain Tetrabenzimidazolium Salts as Ligand Precursors for Silver(I)-N- Heterocyclic Carbene Complexes: Synthesis, Crystal Structure and Antibacterial Studies
Authors: Haziz Umie Fatihah Mohamad , Haque Rosenani Anwarul , Amirul Al-Ashraf Abdullah , Razali Mohd Rizal
Published: May 2022

The synthesis of four silver (I)-N-heterocyclic carbene (NHC) complexes bearing tetrabenzimidazol-2-yl ligands is described. The ligand precursors, open-chain tetrabenzimidazolium salts 1-4 was synthesized by the reaction between 3-(2-bromoethyl)-1-alkylbenzimidazole bromide (alkyl = ethyl, n-propyl, n-butyl, n-benzyl), i-iv with 1,2-ethylbisbenzimidazole in 2:1 molar ratio. Furthermore, their respective silver (I)-NHC complexes Ag1-Ag4 were synthesized via in-situ deprotonation method of the salts with silver oxide in 1:4 molar ratio. The synthesis of all salts and complexes were suggested by melting point, elemental analysis, FTIR studies, 1H and 13C NMR spectra. The reported silver (I)-NHC complexes with tetrabenzimidazol-2-ylidene ligands, Ag5 did not form the expected tetranuclear silver (I)-NHC complexes with the formula of [Ag4(μ4-NHC)2]∙4PF6, but the dinuclear silver (I)-NHC complexes with the formula of [Ag2(μ-NHC)]∙2PF6 was obtained, even after the changes in the molar ratio of the tetrabenzimidazolium salts and metal source. Benzimidazolium salt used as a precursor to synthesize Ag5 is similar to the structures of benzimidazolium salts 1-4, only with the different middle linker; butylene instead of ethylene chain for 1-4. Hence, we proposed that the structure of Ag1-Ag4 is similar to the structure of Ag5, suggested by spectral and elemental studies. From antibacterial study against E. coli (ATCC 25922) and S. aureus (ATCC 12600), all silver (I)-NHC complexes, Ag1-Ag4, show medium to higher activities against both bacteria compared to the standard antibiotic drug, ampicillin, while complexes Ag3 possessed the highest activity among all.
Incorporation of Urea Fertilizer and Activated Carbon in Carboxymethyl Cellulose-Based Bioplastics
Authors: Kartini Indriana , Masuda Masaki , Ishartono Bayu
Published: May 2022

The high mobility of urea as a nitrogen nutrient in the soil leads to inefficient absorption by plants. Hence efforts to design a slow-release fertilizer (SRF) are significant. This paper reports the incorporation of urea fertilizer with carbon or zeolite in a bioplastic made of carboxymethyl cellulose as the matrix. The bioplastics were made by mixing the zeolite or activated carbon suspensions into a sodium carboxymethyl cellulose (Na-CMC) gel. Glycerol was then added as a plasticizer. Six variations of bioplastics were prepared, namely CMC-urea 0.5 and 1.0, CMC-urea-zeolite, CMC-urea-zeolite-glycerol, CMC-urea-activated carbon, and CMC-urea-activated carbon-glycerol. The weight ratio of CMC and urea fertilizer was kept constant at 2:1 since the resulted bioplastics showed higher texture transparency and homogeneity than those of bioplastics with a weight ratio of CMC to urea 1:1. The addition of zeolite increased the tensile strength of the bioplastics by about two times. While, the glycerol addition improved the elongation at break. The release of urea from the bioplastics was slower for bioplastics with zeolite than with activated carbon. The composite bioplastics may serve as a slow-release urea for agriculture.
Emulsion Confinement Self-Assembly Induced Localization of Ag NPs in Janus Polymeric Superparticles
Authors: He Xiao Hong , Jia Kun , Liu Xiao Bo
Published: May 2022

Ag nanoparticles (Ag NPs) showing excellent optical, antistatic and antibiotic properties have been widely applied in antibacterial materials and wearable device, the improvement of oxidative stability of Ag NPs as well as their interfacial interaction with surrounding matrix are the pre-requests for these applications. Emulsion confinement self-assembly of block copolymer and Ag NPs has been considered as one of the most effective strategy to prepare hybrid functional superparticles. Herein, different structured polyarylene ether nitrile (PEN) was employeed as surface capping agent to synthesis Ag NPs and then encapsulated in amphiphilic block copolymer of PEN (amPEN) via emulsion self-assembly. Homo-SHQ shows strongest interaction with Ag+ and the average size of synthesized Ag NPs is about 25 nm. Interestingly, we found that the obtained Ag NPs modified amPEN super-particles showed Janus structure, which is attributed to the controlled localization of Ag NPs in amPEN microparticles enabled by the preferred interfacial interaction. Given the diverse characteristics of Ag NPs, the present work will open the way for self-assembly of Ag NPs to obtain functional devices.
Biosynthesis of Gold Nanoparticles Using Aqueous Extract of Lannea coromandelica Bark with Stabilizer Polyacrylic Acid (PAA) and Polyvinyl Alcohol (PVA)
Authors: Wahab Abdul Wahid , Karim Abdul , La Nafie Nursiah , Febrianti Triana , Azis Nuritasari
Published: May 2022

In this research, we have succeeded in synthesizing gold nanoparticles using an aqueous extract of the bark of Lannea coromandelica. The bark of Lannea coromandelica contains many secondary metabolite chemical compounds that can be used as bioreductants. The gold nanoparticles produced were burgundy or purplish with a maximum wavelength of 528–529 nm with an absorbance of 0.298–0.364 during 5 h of storage at room temperature. The IR results showed that compounds containing O–H, C=O, and C–N groups play a role in reducing gold into nanoparticles. The obtained nanoparticles were pure gold nanoparticles with crystallite sizes by XRD characterization of 44.6 nm and 49.11 nm for AuNP-PAA and AuNP-PVA, respectively.
Copper-Catalyzed-Multicomponent Reaction towards the Synthesis of γ-Hydroxybutyrolactams
Authors: Mardjan Muhammad Idham Darussalam , Parrain Jean Luc , Commeiras Laurent
Published: May 2022

Copper-catalyzed-multicomponent reaction has been applied to prepare several examples γ-hydroxybutyrolactams. The synthesis of γ-hydroxybutyrolactams occurred via cascade sequence comprising Sonogashira coupling, heterocyclization and nucleophilic addition reactions. The reaction involved the starting materials of (Z)-3-iodobutenoic acid, terminal alkynes and butylamine. The results showed that electronic effect of terminal alkynes played important role in synthesis of γ-hydroxybutyrolactams. The multicomponent reaction allowed us to obtain the desired products and to create multiple bonds in one-pot fashion.
Prevalence and Impact of Comorbidities in Individuals with Chronic Obstructive Pulmonary Disease: A Systematic Review
Authors: Santos Natasha Cordeiro dos , Miravitlles Marc , Camelier Aquiles Assunção , Almeida Victor Durier Cavalcanti de , Maciel Roberto Rodrigues Bandeira Tosta , Camelier Fernanda Warken Rosa
Published: May 2022

This study aimed to describe the prevalence of comorbidities associated with chronic obstructive pulmonary disease (COPD) and their relation with relevant outcomes. A systematic review based on the PRISMA methodology was performed from January 2020 until July 2021. The MEDLINE, Lilacs, and Scielo databases were searched to identify studies related to COPD and its comorbidities. Observational studies on the prevalence of comorbidities in COPD patients and costs with health estimates, reduced quality of life, and mortality were included. Studies that were restricted to one or more COPD pain assessments and only specific comorbidities such as osteoporosis, bronchitis, and asthma were excluded. The initial search identified 1,409 studies and after applying the inclusion and exclusion criteria, 20 studies were finally selected for analysis (comprising data from 447,459 COPD subjects). The most frequent COPD comorbidities were: hypertension (range, 17%–64.7%), coronary artery disease (19.9%–47.8%), diabetes (10.2%–45%), osteoarthritis (18%–43.8%), psychiatric conditions (12.1%–33%), and asthma (14.7%–32.5%). Several comorbidities had an impact on the frequency and severity of COPD exacerbations, quality of life, and mortality risk, in particular malignancies, coronary artery disease, chronic heart failure, and cardiac arrhythmias. Comorbidities, especially cardiovascular diseases and diabetes, are frequent in COPD patients, and some of them are associated with higher mortality.
Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)
Authors: Yoon Tae Kwan , Lee Chan Hee , Kwon Obin , Kim Min-Seon
Published: May 2022

Low levels of mitochondrial stress are beneficial for organismal health and survival through a process known as mitohormesis. Mitohormetic responses occur during or after exercise and may mediate some salutary effects of exercise on metabolism. Exercise-related mitohormesis involves reactive oxygen species production, mitochondrial unfolded protein response (UPRmt), and release of mitochondria-derived peptides (MDPs). MDPs are a group of small peptides encoded by mitochondrial DNA with beneficial metabolic effects. Among MDPs, mitochondrial ORF of the 12S rRNA type-c (MOTS-c) is the most associated with exercise. MOTS-c expression levels increase in skeletal muscles, systemic circulation, and the hypothalamus upon exercise. Systemic MOTS-c administration increases exercise performance by boosting skeletal muscle stress responses and by enhancing metabolic adaptation to exercise. Exogenous MOTS-c also stimulates thermogenesis in subcutaneous white adipose tissues, thereby enhancing energy expenditure and contributing to the anti-obesity effects of exercise training. This review briefly summarizes the mitohormetic mechanisms of exercise with an emphasis on MOTS-c.
A Case Series Study of Omphalocele with Associated Anomalies
Authors: Kshitija Kasturi , Elena Krupa , Saritha Seethamsetty , Savitha Sonta
Published: May 2022

Omphalocele is a developmental aberration which occurs during embryonic period in the fetal life. The fault in complete closure of the anterior abdominal wall leading to protrusion of the abdominal viscera mainly the small and large intestines with the liver into the base of umbilical cord insertion forms its main pathological feature. It differs from gastroschisis in that the eviscerated organs are covered by a thin amniotic peritoneal membrane, whereas in latter, the herniated contents are exposed exterior with no covering. In fetuses, this malformation is known to be complicated with abnormal karyotyping, other congenital abnormalities, and idiopathic syndromes which account for grave prognosis. Hence, the aim of our study was to analyze the clinical presentation and document seven cases of fetuses having omphalocele associated with anomalies and chromosomal aberrations leading to fetal dismissal.
Reflections and Insights on the Burden of COVID-19 on Various Facets of Medical Education, Research, and Training
Authors: Patra Apurba , Pushpa N. B. , Ravi Kumar S , Singla Ritika , Pasi Rachna , Singh Shivendra
Published: May 2022

Medical education, an integral part of the modern health-care system, had faced the thrust of the outbreak for the last couple of years. Although the immediate impacts were trivial and managed with online pedagogical approach, on a long run, it seems to spill serious repercussions on medical students, teaching faculties, and administration. Different countries are handling with the situation depending on their financial conditions, task force, and resource allocation. Hence, momentarily, it is quite impractical to reach a global consensus regarding what is the best for students and communities in long run. Meanwhile, each country needs to formulate its own regime to continue with high standard medical teaching and training. Obviously, it may solicit time span, prioritization, and empathy to restructure the medical education without disfiguring its original fabric. The unprecedented use of online pedagogy (prerecorded lectures, medical simulations, virtual cadavers, and video conferencing) has transformed medical education drastically. Although these newer teaching–training policies assisted us to continue with the ongoing curriculum, medical placement/clerkship just resumed with necessary precautions. The assessment part needs extra care and vigilance, as any change or incorporation of newer methods of assessment may even worsen the present state of affairs for both the assessor and the student.
Factors determining intensity of camel adoption in semi-arid north-eastern	Uganda
Authors: Asiimwe R. , Salamula J.B. , Namaawa J. , Diiro G.M. , Egeru A.
Published: May 2022

Integration of camel (Camelus dromedarius) production in the traditional livestock systems is increasingly gaining significance as a strategy for household adaptation to prolonged and recurrent droughts in African arid and semi-arid lands. There is increasing interest in promoting camels as a strategy to mitigate the effects of prolonged droughts in communities where camels have not been reared before. However, the intensity of camel adoption and the factors that drive camel adoption process in semi-arid Uganda are not clear. The objective of this study was to determine the level of intensity and socio-economic factors influencing the intensity of camel adoption in Karamoja sub-region in Uganda. Econometric results show that age the of a household head was significantly associated with the intensity of camel adoption; whereas household size, credit access and crop area cultivated significantly decreased with the intensity of camel adoption in the region. Increasing camel adoption was possible with increasing access to capital; as well as carefully balancing the competition for labour with crop cultivation.