bluuebunny/crossref_metadata_2025 huggingface dataset:
Estudio de la variabilidad en el tiempo y espacio de la actividad antioxidante y composición bioquímica de Kappaphycus alvarezii en diferentes densidades de siembra
Authors: Lema Ch Estefany , Chóez-Guaranda Iván , Ruíz-Barzola Omar , Jaramillo Lorena I. , Pacheco Flores de Valgaz Ángela , Van Den Hende Sofie , Manzano Santana Patricia
Published: March 2023

Kappaphycus alvarezii es una de las especies de algas más cultivadas en el mundo, debido a su alto contenido de compuestos bioactivos con reportes antioxidantes y bioestimulantes. El presente estudio evaluó el efecto de las densidades de plantación sobre la composición bioquímica y antioxidante de K. alvarezii cultivada en un sistema de línea larga durante las estaciones seca y húmeda, con el fin de proporcionar una base científica para una cosecha óptima. Se midieron el contenido de humedad, cenizas, grasa, fibra, auxinas, fenoles, flavonoides, DPPH y ABTS. Los datos se analizaron mediante pruebas t, Wilcoxon, Kruskal-Wallis y ANOVA unidireccional. Los resultados mostraron un mayor contenido de grasa (2,01 % P.s), fibra bruta (5,21% P.s), contenido total de fenoles (324,09 μg GAE/g P.s) y ABTS (9,32 μg GAE/g P.s) durante la estación seca. Con respecto a la densidad de plantación, se produjo un aumento significativo del contenido en cenizas, fenoles totales y ABTS con una densidad de 10 líneas.célula-1 al mismo tiempo. Los contenidos de flavonoides, DPPH y auxina mostraron una tendencia estacional opuesta, alcanzando los niveles máximos en la estación húmeda. Este estudio aporta nueva información sobre las condiciones ambientales que pueden provocar cambios en la actividad antioxidante y la composición bioquímica de esta especie con vistas al desarrollo de bioproductos para diferentes sectores industriales como el alimentario, el farmacéutico y el de los fertilizantes en Ecuador.

Palabras claves: Alga roja; Fenoles; Flavonoides; Antioxidante; Composición bioquímica; Variación estacional; densidad de siembra.
Enhancing Exposure Treatment for Youths With Chronic Pain: Co-design and Qualitative Approach
Authors: Schemer Lea , Hess Courtney W , Van Orden Amanda R , Birnie Kathryn A , Harrison Lauren E , Glombiewski Julia A , Simons Laura E
Published: March 2023

Background

Increasing the access to and improving the impact of pain treatments is of utmost importance, especially among youths with chronic pain. The engagement of patients as research partners (in contrast to research participants) provides valuable expertise to collaboratively improve treatment delivery.

Objective

This study looked at a multidisciplinary exposure treatment for youths with chronic pain through the lens of patients and caregivers with the aim to explore and validate treatment change processes, prioritize and develop ideas for improvement, and identify particularly helpful treatment elements.

Methods

Qualitative exit interviews were conducted with patients and caregivers at their discharge from 2 clinical trials (ClinicalTrials.gov NCT01974791 and NCT03699007). Six independent co-design meetings were held with patients and caregivers as research partners to establish a consensus within and between groups. The results were validated in a wrap-up meeting.

Results

Patients and caregivers described that exposure treatment helped them better process pain-related emotions, feel empowered, and improve their relationship with each other. The research partners developed and agreed upon 12 ideas for improvement. Major recommendations include that pain exposure treatment should be disseminated more not only among patients and caregivers but also among primary care providers and the general public to facilitate an early referral for treatment. Exposure treatment should allow flexibility in terms of duration, frequency, and delivery mode. The research partners prioritized 13 helpful treatment elements. Most of the research partners agreed that future exposure treatments should continue to empower patients to choose meaningful exposure activities, break long-term goals into smaller steps, and discuss realistic expectations at discharge.

Conclusions

The results of this study have the potential to contribute to the refinement of pain treatments more broadly. At their core, they suggest that pain treatments should be disseminated more, flexible, and transparent.
Triggering Weight Management Using Digital Avatars: Prospective Cohort Study
Authors: Jiwa Moyez , Nyanhanda Tafadzwa , Dodson Michael
Published: March 2023

Background

There is evidence that showing motivated people with a less-than-ideal BMI (>25 kg/m2) digital and personalized images of their future selves with reduced body weight will likely trigger them to achieve that new body weight.

Objective

The purpose of this study is to assess whether digital avatars can trigger weight management action and identify some of the measurable factors that distinguish those who may be triggered.

Methods

A prospective cohort study followed participants for 12 weeks through 5 recorded interviews. Participants were screened for suitability for the study using the Cosmetic Procedure Screening Questionnaire as a measure of body dysmorphia. At interview 1, participants were shown 10 images from a “Food-pics” database and invited to estimate their calorie value. The intervention, the FutureMe app, delivered at interview 2, provided each participant an opportunity to see and take away a soft copy of an avatar of themselves as they might appear in the future depending on their calorie consumption and exercise regimen. Participants completed the readiness for change (S-Weight) survey based on Prochaska Stages of Change Model and the processes of change (P-Weight) survey. Any changes in diet, exercise, or weight were self-reported.

Results

A total of 87 participants were recruited, and 42 participants completed the study (48% of recruited participants). Body dysmorphia was a rare but possible risk to participation. The majority (88.5%) of the participants were female and older than 40 years. The average BMI was 34.1 (SD 4.8). Most people wanted to reduce to a BMI of 30 kg/m2 or lose on average 10.5 kg within 13 weeks (–0.8 kg per week). Most participants stated that they would achieve these results by limiting their calorie intake to 1500 calories per day and taking the equivalent of 1 hour of bicycling per day. At interview 1, more participants were in the preparation stage of behavior change than in subsequent interviews. By interview 5, most of the participants were at the maintenance stage. Participants who overestimated the recommended number of calories were more likely to be in the contemplation stage (P=.03).

Conclusions

Volunteers who participated in the study were mainly women older than 40 years and beyond the contemplation stage of change for weight management, and those who took weight management action were demonstrated to have a more accurate idea of the calorie content of different foods. Most participants set ambitious targets for weight loss, but few, if any, achieve these goals. However, most people who completed this study were actively taking action to manage their weight.

Trial Registration

Australian New Zealand Clinical Trials Registry ACTRN12619001481167; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378055&isReview=true
Effectiveness of Combined Health Coaching and Self-Monitoring Apps on Weight-Related Outcomes in People With Overweight and Obesity: Systematic Review and Meta-analysis
Authors: Chew Han Shi Jocelyn , Rajasegaran Nagadarshini Nicole , Chin Yip Han , Chew W S Nicholas , Kim Kyung Mi
Published: March 2023

Background

Self-monitoring smartphone apps and health coaching have both individually been shown to improve weight-related outcomes, but their combined effects remain unclear.

Objective

This study aims to examine the effectiveness of combining self-monitoring apps with health coaching on anthropometric, cardiometabolic, and lifestyle outcomes in people with overweight and obesity.

Methods

Relevant articles published from inception till June 9, 2022, were searched through 8 databases (Embase, CINAHL, PubMed, PsycINFO, Scopus, The Cochrane Library, and Web of Science). Effect sizes were pooled using random-effects models. Behavioral strategies used were coded using the behavior change techniques taxonomy V1.

Results

A total of 14 articles were included, representing 2478 participants with a mean age of 39.1 years and a BMI of 31.8 kg/m2. Using combined intervention significantly improved weight loss by 2.15 kg (95% CI −3.17 kg to −1.12 kg; P<.001; I2=60.3%), waist circumference by 2.48 cm (95% CI −3.51 cm to −1.44 cm; P<.001; I2=29%), triglyceride by 0.22 mg/dL (95% CI −0.33 mg/dL to 0.11 mg/dL; P=.008; I2=0%), glycated hemoglobin by 0.12% (95% CI −0.21 to −0.02; P=.03; I2=0%), and total calorie consumption per day by 128.30 kcal (95% CI −182.67 kcal to −73.94 kcal; P=.003; I2=0%) kcal, but not BMI, blood pressure, body fat percentage, cholesterol, and physical activity. Combined interventional effectiveness was superior to receiving usual care and apps for waist circumference but only superior to usual care for weight loss.

Conclusions

Combined intervention could improve weight-related outcomes, but more research is needed to examine its added benefits to using an app.

Trial Registration

PROSPERO CRD42022345133; https://tinyurl.com/2zxfdpay
Quality evaluation of mHealth applications related to drugs and side effects: deriving essential functions for monitoring adverse drug reactions (Preprint)
Authors: Shin Hyunah , Lee Sangmin , Lee Chungchun , Kwon Mihye , Lee Jisan , Lee Suehyun
Published: March 2023

BACKGROUND

Recent advances in smartphones and wearable devices have led to an increasing number of mHealth mobile applications (mHealth apps), enabling consumers to obtain drug information without the need for hospital visits. Consequently, interest in these apps has increased. However, a comprehensive analysis or quality evaluation has yet to be conducted for a variety of drug-related mobile apps. Content analysis and quality evaluation of mHealth apps not only show their usefulness and utility, but also provide guidance for consumers in selecting and utilizing relevant content and for app developers to implement the necessary functions.

OBJECTIVE

The aim of this study was to identify and analyze drug-related mHealth apps that contain the content and functionality required by consumers for adverse drug reaction (ADR) reporting.

METHODS

We evaluated the usefulness and utility of various drug-related mobile apps, both domestic (Korean) and international, and examined the main functions and features of the selected apps. To increase the reliability of the evaluation, three established assessment tools—the Mobile Application Rating Scale, its user version, and the Korean Health-IT User Evaluation Scale—were utilized. Additionally, mixed research methods comprising both quantitative and qualitative evaluations were conducted through interviews to evaluate the needs of participants regarding drug-related mobile apps and their perceptions of existing apps.

RESULTS

The results of the app quality evaluation showed that the majority of apps focus primarily on providing drug information and lacked features for recording, searching, and reporting ADRs from consumers. Although some international apps have features for reporting 10drug side effects, no such features are available in domestic apps.

CONCLUSIONS

In the future, we intend to develop an mHealth app with features necessary for recording and reporting ADRs the results of this study.
Mobile-based in-home telerehabilitation compared with in-hospital face-to-face rehabilitation for elderly patients after total hip arthroplasty in China’s level 1 trauma center: A noninferiority randomized controlled trial. (Preprint)
Authors: Zhang Xin , Lu Shengdi , Zhang Zhean , Li Hua
Published: March 2023

BACKGROUND

Telerehabilitation is gaining popularity in European and American countries, but whether it can be successfully carried out in China has yet to be supported by clinical studies.

OBJECTIVE

This trial aimed to determine whether a home-based telerehabilitation method is not clinically inferior to standard in-hospital face-to-face rehabilitation for elderly patients with total hip arthroplasty (THA) in China.

METHODS

This multicenter randomized controlled trial was conducted from January 2021 to May 2022 at Shanghai Jiao Tong University affiliated Sixth People’s Hospital and Shanghai Tong Ji University affiliated Tenth People’s Hospital. Sixty-four patients were recruited for this two-arm, single-assessor blinded, randomized controlled trial. The participants were randomly assigned to the in-home telerehabilitation group (TELE group) and the in-hospital physical therapist in-person group (PT group). The intervention consisted of a 12-week home-based rehabilitation program with video instructions and remote coaching on a mobile APP (TELE group). The PT group received a standard rehabilitation intervention assisted by a physical therapist for one month and usual care for the next two months. Patients were evaluated at baseline, 4 weeks, and 12 weeks postoperatively employing functional tests (Timed Up & Go test and Berg balance test) and self-reported questionnaires (Hip disability and Osteoarthritis Outcome Score [HOOS] and Short Form 12 [SF-12]).

RESULTS

There was no significant difference between the two groups for the demographic and clinical characteristics. 61 participants were recruited (PT group: n=31, women: 48.4% of participants; TELE group: n=30, 33.3% of participants) whose median age was 70 and 69 years, in PT group (IQR 63-73) and TELE group (IQR 66-72) respectively. At 12 weeks follow-up evaluation, the main differences between the two groups regarding the HOOS gains, adjusted for baseline values, were close to zero (P > .05). There was no significant difference in primary and secondary outcome measures between the two groups.

CONCLUSIONS

Our results showed the noninferiority of in-home telerehabilitation and advocated its application as a reliable alternative to in-hospital face-to-face rehabilitation for patients who underwent THA.

CLINICALTRIAL

Chinese Clinical Trial Registry (Number: ChiCTR1900025825)
Preference Elicitation and Treatment Decision-Making Among Men Diagnosed With Prostate Cancer: Randomized Controlled Trial Results of Healium (Preprint)
Authors: Diefenbach Michael A , Marziliano Allison , Tagai Erin K , Pfister Halie , Lapitan Emmanuel , Hall Simon J , Vira Manish , Ibrahim Said , Aibel Kelli , Kutikov Alexander , Horwitz Eric M , Miyamoto Curtis , Reese Adam C , Miller Suzanne M
Published: March 2023

BACKGROUND

Elicitation of patients’ preferences is an integral part of shared decision-making, the recommended approach for prostate cancer decision-making. Existing decision aids for this population often do not specifically focus on patients’ preferences. Healium is a brief interactive web-based decision aid that aims to elicit patients’ treatment preferences and is designed for a low health literate population.

OBJECTIVE

This study used a randomized controlled trial to evaluate whether Healium, designed to target preference elicitation, is as efficacious as Healing Choices, a comprehensive education and decision tool, in improving outcomes for decision-making and emotional quality of life.

METHODS

Patients diagnosed with localized prostate cancer who had not yet made a treatment decision were randomly assigned to the brief Healium intervention or Healing Choices, a decision aid previously developed by our group that serves as a virtual information center on prostate cancer diagnosis and treatment. Assessments were completed at baseline, 6 weeks, and 3 months post baseline, and included decisional outcomes (decisional conflict, satisfaction with decision, and preparation for decision-making), and emotional quality of life (anxiety/tension and depression), along with demographics, comorbidities, and health literacy.

RESULTS

A total of 327 individuals consented to participate in the study (171 were randomized to the Healium intervention arm and 156 were randomized to Healing Choices). The majority of the sample was non-Hispanic (272/282, 96%), White (239/314, 76%), married (251/320, 78.4%), and was on average 62.4 (SD 6.9) years old. Within both arms, there was a significant decrease in decisional conflict from baseline to 6 weeks postbaseline (Healium, P≤.001; Healing Choices, P≤.001), and a significant increase in satisfaction with one’s decision from 6 weeks to 3 months (Healium, P=.04; Healing Choices, P=.01). Within both arms, anxiety/tension (Healium, P=.23; Healing Choices, P=.27) and depression (Healium, P=.001; Healing Choices, P≤.001) decreased from baseline to 6 weeks, but only in the case of depression was the decrease statistically significant.

CONCLUSIONS

Healium, our brief decision aid focusing on treatment preference elicitation, is as successful in reducing decisional conflict as our previously tested comprehensive decision aid, Healing Choices, and has the added benefit of brevity, making it the ideal tool for integration into the physician consultation and electronic medical record.

CLINICALTRIAL

ClinicalTrials.gov NCT05800483; https://clinicaltrials.gov/study/NCT05800483
Natural Language Processing of Referral Letters for Machine Learning–Based Triaging of Patients With Low Back Pain to the Most Appropriate Intervention: Retrospective Study (Preprint)
Authors: Fudickar Sebastian , Bantel Carsten , Spieker Jannik , Töpfer Heinrich , Stegeman Patrick , Schiphorst Preuper Henrica R , Reneman Michiel F , Wolff André P , Soer Remko
Published: March 2023

BACKGROUND

Decision support systems (DSSs) for suggesting optimal treatments for individual patients with low back pain (LBP) are currently insufficiently accurate for clinical application. Most of the input provided to train these systems is based on patient-reported outcome measures. However, with the appearance of electronic health records (EHRs), additional qualitative data on reasons for referrals and patients’ goals become available for DSSs. Currently, no decision support tools cover a wide range of biopsychosocial factors, including referral letter information to help clinicians triage patients to the optimal LBP treatment.

OBJECTIVE

The objective of this study was to investigate the added value of including qualitative data from EHRs and referral letters to the accuracy of a quantitative DSS for patients with LBP.

METHODS

A retrospective study was conducted in a clinical cohort of Dutch patients with LBP. Patients filled out a baseline questionnaire about demographics, pain, disability, work status, quality of life, medication, psychosocial functioning, comorbidity, history, and duration of pain. Referral reasons and patient requests for help (patient goals) were extracted via natural language processing (NLP) and enriched in the data set. For decision support, these data were considered independent factors for triage to neurosurgery, anesthesiology, rehabilitation, or minimal intervention. Support vector machine, k-nearest neighbor, and multilayer perceptron models were trained for 2 conditions: with and without consideration of the referral letter content. The models’ accuracies were evaluated via F1-scores, and confusion matrices were used to predict the treatment path (out of 4 paths) with and without additional referral parameters.

RESULTS

Data from 1608 patients were evaluated. The evaluation indicated that 2 referral reasons from the referral letters (for anesthesiology and rehabilitation intervention) increased the F1-score accuracy by up to 19.5% for triaging. The confusion matrices confirmed the results.

CONCLUSIONS

This study indicates that data enriching by adding NLP-based extraction of the content of referral letters increases the model accuracy of DSSs in suggesting optimal treatments for individual patients with LBP. Overall model accuracies were considered low and insufficient for clinical application.
Appropriateness and Comprehensiveness of Using ChatGPT for Perioperative Patient Education in Thoracic Surgery in Different Language Contexts: Survey Study (Preprint)
Authors: Shao Chen-ye , Li Hui , Liu Xiao-long , Li Chang , Yang Li-qin , Zhang Yue-juan , Luo Jing , Zhao Jun
Published: March 2023

BACKGROUND

ChatGPT, a dialogue-based artificial intelligence language model, has shown promise in assisting clinical workflows and patient-clinician communication. However, there is a lack of feasibility assessments regarding its use for perioperative patient education in thoracic surgery.

OBJECTIVE

This study aimed to assess the appropriateness and comprehensiveness of using ChatGPT for perioperative patient education in thoracic surgery in both English and Chinese contexts.

METHODS

This pilot study was conducted in February 2023. A total of 37 questions focused on perioperative patient education in thoracic surgery were created based on guidelines and clinical experience. Two sets of inquiries were made to ChatGPT for each question, one in English and the other in Chinese. The responses generated by ChatGPT were evaluated separately by experienced thoracic surgical clinicians for appropriateness and comprehensiveness based on a hypothetical draft response to a patient’s question on the electronic information platform. For a response to be qualified, it required at least 80% of reviewers to deem it appropriate and 50% to deem it comprehensive. Statistical analyses were performed using the unpaired chi-square test or Fisher exact test, with a significance level set at P<.05.

RESULTS

The set of 37 commonly asked questions covered topics such as disease information, diagnostic procedures, perioperative complications, treatment measures, disease prevention, and perioperative care considerations. In both the English and Chinese contexts, 34 (92%) out of 37 responses were qualified in terms of both appropriateness and comprehensiveness. The remaining 3 (8%) responses were unqualified in these 2 contexts. The unqualified responses primarily involved the diagnosis of disease symptoms and surgical-related complications symptoms. The reasons for determining the responses as unqualified were similar in both contexts. There was no statistically significant difference (34/37, 92% vs 34/37, 92%; P=.99) in the qualification rate between the 2 language sets.

CONCLUSIONS

This pilot study demonstrates the potential feasibility of using ChatGPT for perioperative patient education in thoracic surgery in both English and Chinese contexts. ChatGPT is expected to enhance patient satisfaction, reduce anxiety, and improve compliance during the perioperative period. In the future, there will be remarkable potential application for using artificial intelligence, in conjunction with human review, for patient education and health consultation after patients have provided their informed consent.
D-Dimer Sebagai Salah Satu Parameter Perbaikan Klinis pada Kasus Covid-19 Gejala Berat
Authors: Trilaksmi Antin , Martin
Published: March 2023

Background. Coronavirus Disease 2019 (COVID-19) has been a global pandemic since March 2020. The number of patients is massive and clinical symptoms vary from mild to severe symptoms. Several laboratory results showed abnormal values in Covid-19 patients, including an increase in the value of D-dimer. Elevated levels of D-dimer in COVID-19 patients are strongly associated with severity and increased mortality. We report a case of a severe symptomatic COVID-19 patient with high D dimer levels at the start of treatment and showing clinical improvement according to a decrease in D dimer levels.
Methods. We treat and follow the clinical and laboratory developments of COVID-19 patients with severe symptoms from the time they enter the Intensive Care Unit (ICU) until they move to a regular ward.
Results. A 53-year-old male patient diagnosed with viral pneumonia et causa covid-19 was admitted to the ICU with severe symptoms and high initial d-dimer levels (1,413 ug/ml). The patient received ventilator assistance and standard therapy according to the Covid 19 management protocol of the Ministry of Health of the Republic of Indonesia. Anticoagulation using heparin intravenously with a dose adjusted to the level of d dimer, aPTT, and clinical condition of the patient who is monitored regularly. The trend of d dimers decreased parallel to the decrease in C reactive protein (CRP) levels, increased lung gas exchange function was evaluated from the PaO2/Fio2 ratio (PF ratio) and the clinical improvement of the patients.
Conclusion. D-dimer is closely related to the severity of covid 19 patients. D dimer can be used as one of the parameters of patient clinical improvement.
Pengaruh Pemakaian Masker Bedah dan Masker Kain pada Wajah
Authors: Sutanto Hans , Saroso Ade , Setyaningrum Dyah , Ilona Florinda
Published: March 2023

Background. Face masks are indispensable in preventing the spread of COVID-19 transmission. Face mask use can have beneficial and detrimental effects on a person. In this study, participants' faces were observed before and after wearing surgical and cloth masks for 4 hours per day for five consecutive days.
Methods. The research design is experimental.
Results. Thirty-two Trisakti University Faculty of Medicine employees aged 26 to 46 years and 18 men and 14 women, participated in this study. Sociodemographic data and facial examination were assessed at the start and end of the study. The research data obtained the results of p = 0.392.
Conclusion. There is no significant difference between surgical and cloth masks in terms of acne, skin irritation, and redness.
Quantum manipulation of a two-level mechanical system
Authors: Chiavazzo Salvatore , Sørensen Anders Søndberg , Kyriienko Oleksandr , Dellantonio Luca
Published: March 2023

We consider a nonlinearly coupled electromechanical system, and develop a quantitative theory for two-phonon cooling. In the presence of two-phonon cooling, the mechanical Hilbert space is effectively reduced to its ground and first excited states, allowing for quantum operations at the level of individual phonons and preparing nonclassical mechanical states with negative Wigner functions. We propose a scheme for performing arbitrary Bloch sphere rotations, and derive the fidelity in the specific case of a π-pulse. We characterise detrimental processes that reduce the coherence in the system, and demonstrate that our scheme can be implemented in state-of-the-art electromechanical devices.
Complete response to cetuximab plus paclitaxel therapy in nivolumab-refractory patients in distant metastasis of squamous cell carcinoma of the tongue: a report of two cases
Authors: Tachinami Hidetake , Tomihara Kei , Takatsuka Danki , Ikeda Atsushi , Yamada Shin-ichi , Noguchi Makoto
Published: March 2023

Herein, we report two cases of patients diagnosed with
nivolumab-refractory distant metastatic squamous cell carcinoma of the
tongue who were successfully treated with a combination of paclitaxel
and cetuximab, thus demonstrating that some nivolumab-refractory
patients with recurrent or distant metastatic oral squamous cell
carcinoma may benefit from subsequent salvage chemotherapy.
Varicella-Zoster Virus reactivation following COVID-19 vaccination: A Tunisian case series
Authors: Ferchichi Khouloud , Aouinti Imen , Zaiem Ahmed , Lakhoua Ghozlane , Kaabi Widd , Daghfous Riadh , Aidli Sihem El
Published: March 2023

Introduction: Reactivation of varicella-zoster virus (VZV) most commonly
manifests as shingles. A few months after the start of the COVID-19
vaccination campaign cases of shingles were reported. Objective: We
aimed to report cases of VZV reactivation reported after COVID-19
vaccination to the Tunisian National Centre of pharmacovigilance (NCPV).
Method: This is a retrospective study of cases of VZV reactivation
reported to the CNPV after COVID-19 vaccination from March 2021 to May
2022. Results: We included 20 patients with shingle. The sex ratio (M/F)
was 0.8. The median age was 68.5 years. Nine patients were over 70 years
of age. The administered vaccines were an mRNA vaccine for 15 patients.
The onset delay ranged between one and 30 days (mean of 4.5 days). All
patients recovered within a few days and no severe cases have been
reported. Two patients received the second dose; One patient did not
experience a recurrence of the symptomatology. The other patient, had
aggravation of symptomatology and occurrence of facial paralysis; noting
that the initial symptomatology did not entirely disappear when the
patient received the second dose. The patient was diagnosed with Ramsay
Hunt Syndrome. Conclusion: Our study draws attention to the
chronological association between SARS-CoV-2 vaccine and VZV
reactivation, which should be investigated.
DISCUSSION ON SEISMICALLY TRIGGERED AVALANCHES ON MARS
Authors: Lucas Antoine , Daubar I J , Teuff M Le , Posiolova L V , Sainton G , Mangeney A , Perrin C , Kawamura T , Giardini D , Lognonné P
Published: March 2023

Motivation: On May 5, 2022, the martian SEIS seismometer recorded an
unprecedented M Ma W 4.7 Marsquake. The epicenter is located at 3.0 • S,
171.9 • E. The areas is barely flat with only a few N-S tectonic-like
features. Most unfilled impact craters and ridges show dust avalanches
(a.k.a. Slope streaks). We investigate the post-seismic outcomes in
terms of avalanche triggering under today’s Mars conditions in the
framework of the s1222a event.
Emergence of unstable focused flow induced by variable-density flows in vertical fractures
Authors: Cao Hongfan , Yoon Seonkyoo , Xu Zhenyu , Pyrak-Nolte Laura , Bresciani Etienne , Kang Peter K
Published: March 2023

Fluids with different densities often coexist in subsurface fractures
and lead to variable-density flows that control subsurface processes
such as seawater intrusion, contaminant transport, and geologic carbon
sequestration. In nature, fractures have dip angles relative to gravity,
and density effects are maximized in vertical fractures. However, most
studies on flow and transport through fractures are often limited to
horizontal fractures. Here, we study the mixing and transport of
variable density fluids in vertical fractures by combining
three-dimensional (3D) pore-scale numerical simulations and visual
laboratory experiments. Two miscible fluids with different densities are
injected through two inlets at the bottom of a fracture and exit from an
outlet at the top of the fracture. Laboratory experiments show the
emergence of an unstable focused flow path, which we term a “runlet.”
We successfully reproduce an unstable runlet using 3D numerical
simulations, and elucidate the underlying mechanisms triggering the
runlet. Dimensionless number analysis shows that the runlet instability
arises due to the Rayleigh-Taylor instability, and flow topology
analysis is applied to identify 3D vortices that are caused by the
Rayleigh-Taylor instability. Even under laminar flow regimes, fluid
inertia is shown to control the runlet instability by affecting the size
and movement of vortices. Finally, we confirm the emergence of a runlet
in rough-walled fractures. Since a runlet dramatically affects fluid
distribution, residence time, and mixing, the findings in this study
have direct implications for the management of groundwater resources and
subsurface applications.
Estratégias gerenciais em uma comunicação eficaz
Authors: Vivas Amely , Veja Juan , Martínez Marlenis , Soto Fernando
Published: March 2023

O objetivo deste estudo foi descrever estratégias gerenciais que melhoram a comunicação eficaz em professores da escola Ignacio Verdugo Cavada na comuna de Mulchén na Região Bio-Bio-Chile. O percurso metodológico centrou-se na abordagem quantitativa com tipo de pesquisa descritiva e com uma população de 25 educadores que atuam na referida instituição. Da mesma forma, a pesquisa utilizou como técnica e como instrumento um questionário com o uso da escala Likert com respostas alternativas: Sempre, Quase Sempre, Às Vezes, Quase Nunca e Nunca. Dentre os resultados obtidos, verifica-se que a equipe gestora carece do estabelecimento de metas gerenciais que levem à tomada de decisões entre os docentes. Os achados encontrados afirmam que os gestores precisam dar orientações que influenciem nos processos de comunicação, bem como a urgente necessidade de executar estratégias que otimizem a comunicação e a integração coletiva para melhorá-la entre os educadores.
Some biological aspects of Mediterranean mud shrimp, Upogebia pusilla (Petagna, 1792) in the Boka Kotorska Bay, Southeastern Adriatic Sea
Authors: Markovic Olivera , Djurovic Mirko , Ikica Zdravko , Huter Aleksandra
Published: March 2023

Biological aspects (length frequency distribution, length-weight ratio, sex ratio, allometric growth, Fulton?s condition factor) of Upogebia pusilla were studied in Tivat Saline (Tivatska solila), Boka Kotorska Bay in 2019. A total of 1,415 individuals were collected. The total length of all studied individuals ranged from 27 to 55 mm (8 and 20 mm CL), while the total weights ranged from 0.29 to 2.56 g (the total length of males ranged from 27 to 51 mm, non-ovigerous and ovigerous females ranged from 27 to 51 mm and 30 to 55 mm, respectively; the weights ranged from 0.29 to 2.52 g, 0.34 to 2.52 g and 0.47 to 2.56 g for males, non-ovigerous and ovoid females, respectively). The overall female:male ratio was 1.2:1. Ovigerous females were recorded from April (74.3%) to June (23.8%), with a peak in May (91.4% of all females). Males dominated in July (66.4%). The relationship between CL and W was negatively allometric in both males and females and in all sampled individuals. Fulton?s condition factor was higher only in females during the breeding season, while there were no significant differences between males and females during the rest of the year. Since this species is mainly used as live bait for commercial and sports fishermen, the results of this study would be useful for the sustainable management of this species.
Logical dependencies: Extraction from the versioning system and usage in key classes detection
Authors: Stana Adelina , Şora Ioana
Published: March 2023

The version control system of every software product can provide important information about how the system is connected. In this study, we first propose a language-independent method to collect and filter dependencies from the version control, and second, we use the results obtained in the first step to identify key classes from three software systems. To identify the key classes, we are using the dependencies extracted from the version control system together with dependencies from the source code, and also separate. Based on the results obtained we can say that compared with the results obtained by using only dependencies extracted from code, the mix between both types of dependencies provides small improvements. And, by using only dependencies from the version control system, we obtained results that did not surpass the results previously mentioned, but are still acceptable. We still consider this an important result because this might open an important opportunity for software systems that use dynamically typed languages such as JavaScript, Objective-C, Python, and Ruby, or systems that use multiple languages. These types of systems, for which the code dependencies are harder to obtain, can use the dependencies extracted from the version control to gain better knowledge about the system.
Using deep learning to automatic inspection system of printed circuit board in manufacturing industry under the internet of things
Authors: Zhang Kai
Published: March 2023

Industry 4.0 is currently the goal of many factories, promoting manufacturing factories and sustainable operation. Automated Optical Inspection (AOI) is a part of automation. Products in the production line are usually inspected visually by operators. Due to human fatigue and inconsistent standards, product inspections still have defects. In this study, the sample component assembly printed circuit board (PCB), PCB provided by the company was tested for surface components. The types of defects on the surface of the PCB include missing parts, multiple parts, and wrong parts. At present, the company is still using visual inspection by operators, the PCB surface components are more complex. In order to reduce labor costs and save the development time required for different printed circuit boards. In the proposed method, we use digital image processing, positioning correction algorithm, and deep learning YOLO for identification, and use 450 images and 10500 components of the PCB samples. The result and contribution of this paper shows the total image recognition rate is 92% and the total component recognition rate reaches 99%, and they are effective. It could use on PCB for different light, different color backplanes, and different material numbers, and the detection compatibility reaches 98%.
Using artificial intelligence assistant technology to develop animation games on IoT
Authors: Zhang Rong
Published: March 2023

This research proposes an XNA animation game system with AI technology for action animation games in mobile devices, based on an object-oriented modular concept. The animation game function with AI technology is encapsulated into independent objects, through the combination of objects to build repetition. It adds AI technology to the finite state machine, fuzzy state machine and neural network and attempts to combine the traditional rule-base system and learning adaptation system to increase the learning ability of traditional AI roles. The main contributions are compared with traditional methods and the AI animation game system is shown to have more reusability, design flexibility and expansibility of its AI system through the object composition approach. It adds AI technology to combine the traditional rule-base system and learning adaptation system to increase the learning ability of traditional AI roles. Therefore, AI animation game producers can accelerate their processes of developing animation games and reducing costs.
Expected utility for probabilistic prospects and the common ratio property
Authors: Lahiri Somdeb
Published: March 2023

We prove the existence of an expected utility function for preferences over probabilistic prospects satisfying Strict Monotonicity, Indifference, the Common Ratio Property, Substitution and Reducibility of Extreme Prospects. The example in [1] that is inconsistent with the existence of a von Neumann-Morgenstern for preferences over probabilistic prospects, violates the Common Ratio Property. Subsequently, we prove the existence of expected utility functions with piecewise linear Bernoulli utility functions for preferences that are piece-wise linear. For this case a weaker version of the Indifference Assumption that is used in the earlier existence theorems is sufficient. We also state analogous results for probabilistic lotteries. We do not require any compound prospects or mixture spaces to prove any of our results. In the third last section of this paper, we ?argue? that the observations related to Allais paradox, do not constitute a violation of expected utility maximization by individuals, but is a likely manifestation of individuals assigning (experiment or menu-dependent?) subjective probabilities to events which disagree with their objective probabilities.
Predicting Fatigue Life of A Mount of A Device with Shock Absorber
Authors: TEKECİ Uğur , YILDIRIM Bora
Published: March 2023

All aircraft operate under vibration loads and these loads cause vibration-induced fatigue damage to the parts. Fatigue damages are dangerous because they occur suddenly without giving a warning before, for this reason they need to be carefully analyzed. In the analysis, especially the natural frequencies and dampings must be determined correctly, because when the vibration loads match with the natural frequencies, resonance is observed and this reduces the life of the part. In this study, the fatigue life of a mount of a device with shock absorber is investigated. Flight tests were carried out in real flight scenarios to provide an input for the analysis. A modal test was performed to model the shock absorbers correctly. Vibration test was performed to prove the accuracy of the prepared finite element model and to determine the damping ratios. Fatigue analyses were performed in frequency domain with a commercial software, nCode, and the accuracy of the analysis was proven by the experiment.
Moroxydine: the story of a mislaid antiviral
Authors: Sheppard Simon
Published: March 2023

A review is presented which began as a literature survey listing verbatim over fifty abstracts and references to the use of moroxydine in the treatment of a number of viral disorders throughout Europe and Scandinavia between 1960 and 1985. The list was first circulated in 1990 and was revised six times as new information became available. The sources are unusual in their diversity and originally appeared in several other languages besides English. Moroxydine may be effective against a number of DNA and RNA viruses, influenza being the original application of the substance when it emerged in the late 1950's. The drug received some attention around 1960, and the introduction of thalidomide at around the same time (1961) is one likely explanation for its current obscurity. Side-effects are reported to be mild and infrequent, and evidence exists that the substance possesses other characteristics which plead for further investigation.
Hereditary palmoplantar keratoderma and dermatophytosis in the northernmost county of Sweden (Norrbotten)
Authors: Nielsen Povl Gamborg
Published: March 2023

Clinical reports of hereditary palmoplantar keratoderma are generally based on a limited number of patients. In 1967 the prevalence in the northernmost county of Sweden (Norrbotten) was shown to be 0.55%. In 1982 it was possible to trace half of the original propositi from that study. Among these families, a severe clinical form with a presumed recessive inheritance could be distinguished. The clinical pictures in relatives of the original propositi were described, and other diseases were listed together with those in patients from previously performed studies. The frequency of dermatophytosis was 36.2%, which was equal to a prevalence of 37.6%. T. mentagrophytes occurred significantly more often and immunological factors, such as increased presence of blood group A, specific dermatophyte IgG antibodies, precipitating antibodies and an immunological in vitro reaction to keratin, supported differences in the distribution of dermatophytes. However, the amount of keratin was considered the most important factor for the affinity of dermatophytes to the palms and soles. A vesicular eruption along the hyperkeratotic border and a mononuclear cell infiltrate were often reported. Such reactions were interpreted as immunological reactions to dermatophytosis. Scaling and fissuring were considered clinical signs of dermatophyte infections and not a part of the originally reported clinical picture. Results of the histopathological study corresponded to previously reported descriptions of the Unna-Thost variety. However, it has recently been reported that the histopathological picture of this variety was based on histopathological features of epidermolytic palmoplantar keratoderma. The existence on the Continent of the Unna-Thost variety was therefore questioned. Histopathological features of epidermolytic palmoplantar keratoderma were not found in the County of Norrbotten and the designation "Diffuse HPPK type Norrbotten" has therefore been proposed. The histopathological picture of the presumed recessive variety did not differ from that of the dominant variety but ultrastructural characteristics differentiated it from Mal de Meleda and the dominant variety. It was therefore concluded that a new variety with a presumed recessive inheritance was found.
Hyalinosis cutis et mucosae. An electron microscopic study
Authors: Hashimoto K. , Klingmüller G. , Rodermund OE.
Published: March 2023

No abstract available
Occurrence of antinuclear factors and immunoglobulins bound to the dermo-epidermal junction in patients with chronic biological false positive (CBFP) reactions for syphilis
Authors: Johansson EA. , Lassus A. , Salo OP.
Published: March 2023

No abstract available
Prevalence of oral lichen planus among 7639 Indian villagers in Kerala, South India
Authors: Pindborg JJ. , Mehta FS. , Daftary DK. , Gupta PC. , Bhonsle RB.
Published: March 2023

No abstract available
Studies on the possible role of histamine in the pathogenesis of ringworm infections
Authors: Gip L. , Hägermark O.
Published: March 2023

No abstract available
Receptors for immunoglobulins on emigrated eosinophil leukocytes. The role of eosinophils
Authors: Szekeres L. , Szabo E.
Published: March 2023

No abstract available
An unusual auto-immune syndrome. A follow-up with reference to breast hypertrophy, systemic lupus erythematosus and verrucae
Authors: Shelley WB.
Published: March 2023

No abstract available
Blood group antibodies as a source of error in the diagnosis of pemphigus by indirect immunofluorescence
Authors: Olson K. , Biberfeld G. , Fagraeus A.
Published: March 2023

No abstract available
Tetracycline-resistant staphylococci in acne vulgaris
Authors: Shalita AR. , Rosenthal SA.
Published: March 2023

No abstract available
Evaluation of the C.S.F. F.T.A. ABS test in latent and tertiary treated syphilis
Authors: Mahony JD. , Harris JR. , McCann JS. , Kennedy J. , Dougan HJ.
Published: March 2023

No abstract available
Inter-Rater Reliability of Novice Linkers Using an Innovative Sequential Iterative Linking Method to Link Prosthetic Outcomes to The International Classification of Functioning, Disability and Health
Authors: Clarke Leigh , Ridgewell Emily , Li Xia , Dillon Michael P.
Published: March 2023

Objective: When linking outcomes to the International Classification of Functioning, Disability and Health (ICF), inter-rater reliability is typically assessed at the conclusion of the linking process. This method does not allow for iterative evaluation and adaptations that would improve inter-rater reliability as novices gain experience. This pilot study aims to quantify the inter-rater reliability of novice linkers when using an innovative, sequential, iterative linking method to link prosthetic outcomes to the ICF.Methods: Across 5 sequential rounds, 2 novices independently linked outcomes to the ICF. A consensus discussion followed each round that informed refinement of the customized ICF linking rules. The inter-rater reliability was calculated for each round using Gwet’s agreement coefficient (AC1).Results: A total of 1,297 outcomes were linked across 5 rounds. At the end of round 1 inter-rater reliability was high (AC1 = 0.74, 95% confidence interval (95% CI) 0.68–0.80). At the end of round 3, interrater reliability (AC1 = 0.84, 95% CI 0.80–0.88) was significantly improved and marked the point of consistency where further improvements in inter-rater reliability were not statistically significant.Conclusion: A sequential iterative linking method provides a learning curve that allows novices to achieve high-levels of agreement through consensus discussion and iterative refinement of the customized ICF linking rules.
LAY ABSTRACTOutcomes are commonly used in healthcare and research to evaluate the effect of an intervention or treatment, such as the effect a prosthesis has on the ability to walk in the community or participate in activities. Cataloguing outcomes using well-established classification systems, such as the International Classification of Functioning, Disability and Health, is important, as it allows outcomes and research to be described using an internationally understood and agreed language. This study aimed to describe an innovative approach to cataloguing outcomes to the ICF, using a method that provides novices with a learning opportunity. In using this innovative method novices were able to catalogue outcomes to the ICF framework with a similar degree of reliability as experts. This will reduce the barriers to novices conducting this type of research in the future.