bluuebunny/crossref_metadata_2025 huggingface dataset:
Correction to: Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebocontrolled, randomised, double blind, multi-centre study
Authors:   on behalf of the NOSTRA Investigators, Tegtmeier Frank , Schinzel Reinhard , Beer Ronny , Bulters Diederik , LeFrant Jean-Yves , Sahuquillo Joan , Unterberg Andreas , Andrews Peter , Belli Antonio , Ibanez Javier , Lagares Alfonso , Mokry Michael , Willschke Harald , Flüh Charlotte , Schmutzhard Erich
Published: February 2020

After publication of our article [1] the authors have notified us that one of the names has been incorrectly spelled.
Tumour necrosis factor alpha promotes secretion of 14-3-3η by inducing necroptosis in macrophages
Authors: Trimova Gulzhan , Yamagata Kaoru , Iwata Shigeru , Hirata Shintaro , Zhang Tong , Uemura Fumi , Satoh Minoru , Biln Norma , Nakayamada Shingo , Maksymowych Walter P. , Tanaka Yoshiya
Published: February 2020

Background

14-3-3η is an intracellular protein also detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA). It is closely related to disease activity and anti-cyclic citrullinated peptide antibody levels. However, the main source of 14-3-3η and the mechanism of its release into the extracellular space remain unclear. Addressing these two points was the main goal of the current study.

Methods

The source of 14-3-3η was investigated by immunostaining RA synovial tissue. Fibroblast-like synoviocytes, CD4+ cells, and macrophages were selected as candidates among the various cell types in the synovial tissue. Phosphorylation of mixed-lineage kinase domain-like pseudokinase (MLKL) and cell death of macrophages were studied by phalloidin staining and electron microscopy after stimulation with an oxidative stress inducer (diamide) or tumour necrosis factor (TNF)-α. Extracellular 14-3-3η protein levels were examined by western blotting.

Results

Macrophages from the synovial tissue from RA, but not osteoarthritis, showed dense and widespread cytoplasmic staining for the 14-3-3η protein, co-localized with peptidylarginine deiminase 4. Swelling and membrane rupture of macrophages were induced by treatment with TNF-α, but not interleukin (IL) 6/soluble IL-6 receptor (sIL-6R). Increased MLKL phosphorylation followed by necroptosis was also induced in TNF-α-stimulated macrophages. Necrostatin-1, a necroptosis inhibitor, antagonized MLKL phosphorylation. High levels of 14-3-3η were detected in the culture supernatants of macrophages stimulated with diamide and TNF-α, but not IL-6/sIL-6R.

Conclusions

Macrophages that highly express 14-3-3η undergo TNF-α-induced necroptosis with damage to the cellular structure, resulting in the secretion of 14-3-3η into the extracellular space. The current study provides a novel mechanism for 14-3-3η level increase in the RA synovial fluid.
Maize genomes to fields (G2F): 2014–2017 field seasons: genotype, phenotype, climatic, soil, and inbred ear image datasets
Authors: McFarland Bridget A. , AlKhalifah Naser , Bohn Martin , Bubert Jessica , Buckler Edward S. , Ciampitti Ignacio , Edwards Jode , Ertl David , Gage Joseph L. , Falcon Celeste M. , Flint-Garcia Sherry , Gore Michael A. , Graham Christopher , Hirsch Candice N. , Holland James B. , Hood Elizabeth , Hooker David , Jarquin Diego , Kaeppler Shawn M. , Knoll Joseph , Kruger Greg , Lauter Nick , Lee Elizabeth C. , Lima Dayane C. , Lorenz Aaron , Lynch Jonathan P. , McKay John , Miller Nathan D. , Moose Stephen P. , Murray Seth C. , Nelson Rebecca , Poudyal Christina , Rocheford Torbert , Rodriguez Oscar , Romay Maria Cinta , Schnable James C. , Schnable Patrick S. , Scully Brian , Sekhon Rajandeep , Silverstein Kevin , Singh Maninder , Smith Margaret , Spalding Edgar P. , Springer Nathan , Thelen Kurt , Thomison Peter , Tuinstra Mitchell , Wallace Jason , Walls Ramona , Wills David , Wisser Randall J. , Xu Wenwei , Yeh Cheng-Ting , de Leon Natalia
Published: February 2020

Objectives

Advanced tools and resources are needed to efficiently and sustainably produce food for an increasing world population in the context of variable environmental conditions. The maize genomes to fields (G2F) initiative is a multi-institutional initiative effort that seeks to approach this challenge by developing a flexible and distributed infrastructure addressing emerging problems. G2F has generated large-scale phenotypic, genotypic, and environmental datasets using publicly available inbred lines and hybrids evaluated through a network of collaborators that are part of the G2F’s genotype-by-environment (G × E) project. This report covers the public release of datasets for 2014–2017.

Data description

Datasets include inbred genotypic information; phenotypic, climatic, and soil measurements and metadata information for each testing location across years. For a subset of inbreds in 2014 and 2015, yield component phenotypes were quantified by image analysis. Data released are accompanied by README descriptions. For genotypic and phenotypic data, both raw data and a version without outliers are reported. For climatic data, a version calibrated to the nearest airport weather station and a version without outliers are reported. The 2014 and 2015 datasets are updated versions from the previously released files [1] while 2016 and 2017 datasets are newly available to the public.
A greedy stacking algorithm for model ensembling and domain weighting
Authors: Kurz Christoph F. , Maier Werner , Rink Christian
Published: February 2020

Objective

Because it is impossible to know which statistical learning algorithm performs best on a prediction task, it is common to use stacking methods to ensemble individual learners into a more powerful single learner. Stacking algorithms are usually based on linear models, which may run into problems, especially when predictions are highly correlated. In this study, we develop a greedy algorithm for model stacking that overcomes this issue while still being very fast and easy to interpret. We evaluate our greedy algorithm on 7 different data sets from various biomedical disciplines and compare it to linear stacking, genetic algorithm stacking and a brute force approach in different prediction settings. We further apply this algorithm on a task to optimize the weighting of the single domains (e.g., income, education) that build the German Index of Multiple Deprivation (GIMD) to be highly correlated with mortality.

Results

The greedy stacking algorithm provides good ensemble weights and outperforms the linear stacker in many tasks. Still, the brute force approach is slightly superior, but is computationally expensive. The greedy weighting algorithm has a variety of possible applications and is fast and efficient. A python implementation is provided.
Combining PRNU and noiseprint for robust and efficient device source identification
Authors: Cozzolino Davide , Marra Francesco , Gragnaniello Diego , Poggi Giovanni , Verdoliva Luisa
Published: February 2020

PRNU-based image processing is a key asset in digital multimedia forensics. It allows for reliable device identification and effective detection and localization of image forgeries, in very general conditions. However, performance impairs significantly in challenging conditions involving low quality and quantity of data. These include working on compressed and cropped images or estimating the camera PRNU pattern based on only a few images. To boost the performance of PRNU-based analyses in such conditions, we propose to leverage the image noiseprint, a recently proposed camera-model fingerprint that has proved effective for several forensic tasks. Numerical experiments on datasets widely used for source identification prove that the proposed method ensures a significant performance improvement in a wide range of challenging situations.
Evolutionary understanding of the conditions leading to estimation of behavioral properties through system dynamics
Authors: Park Chulwook
Published: February 2020

One of the basic approaches in science views behavioral products as a process within a dynamic system. The mechanism might be seen as a representation of many instances of centralized control in real time. Many real systems, however, exhibit autonomy by denying statically treated mechanisms. This study addresses the issues related to the identification of dynamic systems and suggests how determining the basic principles of a collective structure may be the key to understanding complex behavioral processes. A fundamental model is derived to assess the advantages of this perspective using a basic methodology. The connection between perspective and technique demonstrates certain aspects within their actual context while also clearly including the framework of actual dynamic system identification.
The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas
Authors: McCord Matthew , Steffens Alicia , Javier Rodrigo , Kam Kwok-Ling , McCortney Kathleen , Horbinski Craig
Published: February 2020

A subset of gliomas has DNA repair defects that lead to hypermutated genomes. While such tumors are resistant to alkylating chemotherapies, they may also express more mutant neoantigens on their cell surfaces, and thus be more responsive to immunotherapies. A fast, inexpensive method of screening for hypermutated gliomas would therefore be of great clinical value. Since immunohistochemistry (IHC) for the DNA mismatch repair (MMR) proteins Msh2, Msh6, Mlh1, and Pms2 is already used to screen for hypermutated colorectal cancers, we sought to determine whether that panel might have similar utility in gliomas. MMR IHC was scored in 100 WHO grade I-IV gliomas (from 96 patients) with known tumor mutation burden (TMB), while blinded to TMB data. Cases included 70 grade IV GBMs, 13 grade III astrocytomas, 4 grade II astrocytomas (3 diffuse astrocytomas and 1 pleomorphic xanthoastrocytoma), 1 grade I pilocytic astrocytoma, 2 grade III oligodendrogliomas, 7 grade II oligodendrogliomas, and 3 grade I glioneuronal tumors. Eight of 100 tumors showed loss of one or more MMR proteins by IHC, and all 8 were hypermutated. Among the remaining 92 gliomas with intact MMR IHC, only one was hypermutated; that tumor had an inactivating mutation in another DNA repair gene, ATM. Overall accuracy, sensitivity, and specificity for DNA MMR IHC compared to the gold standard of TMB were 99, 89, and 100%, respectively. The strongest correlates with hypermutation were prior TMZ treatment, MGMT promoter methylation, and IDH1 mutation. Among the 8 MMR-deficient hypermutated gliomas, 4 (50%) contained both MMR-lost and MMR-retained tumor cells. Together, these data suggest that MMR IHC could be a viable front-line screening test for gliomas in which immunotherapy is being considered. They also suggest that not all cells in a hypermutated glioma may actually be MMR-deficient, a finding that might need to be considered when treating such tumors with immunotherapies.
Mental images, entrapment and affect in young adults meeting criteria of nonsuicidal self-injury disorder (NSSID) – a daily diary study
Authors: Cloos Marie , Di Simplicio Martina , Hammerle Florian , Steil Regina
Published: February 2020

Background

Incidents of nonsuicidal self-injury (NSSI) are often accompanied by mental images which could be perceived as distressing and/or soothing; yet existing data is derived from participants with a history of NSSI using retrospective methods. This study investigated mental images related to NSSI (“NSSI-images”), and their relationship to the proposed Nonsuicidal Self-Injury Disorder (NSSID).

Methods

An e-mail was sent to all female students of the local University providing the link to an online screening and 201 students with a history of repetitive NSSI responded. Nineteen eligible participants meeting criteria of NSSID (mean age = 25; 32% with migrant background) further completed a baseline interview and a ten-day-diary protocol.

Results

Among the sample of N = 201, 83.6% reported NSSI-images. In the subsample of n = 19 diagnosed with NSSID, the frequencies of NSSI and NSSI-images were correlated; about 80% of the most significant NSSI-images were either of NSSI or of an instrument associated with NSSI (i.e., a razorblade). In the diary, 53% of the sample self-injured. NSSI-images were reported on 94% of NSSI-days, and on days with NSSI and NSSI-images, the images almost always occurred first; the images were overall perceived as twice more distressing than comforting. Images on NSSI-days were characterized by more comfort, intrusiveness and compellingness yet less vividness, and increased subsequent positive and negative affect compared to non-NSSI days. NSSI-days were further marked by increased entrapment beliefs and increased negative yet decreased positive affect at night. These results were non-significant.

Limitations

Due to non-significant results among a small sample size and a low rate of NSSI among the NSSID-group, results remain preliminary.

Conclusions

The study provides information on feasibility and methodological challenges such as intervention effects of the diary. NSSI-images may be common among individuals who engage in NSSI; they may capture ambivalent (positive and negative) appraisals of NSSI and thus play a role in NSSI and possibly a disorder such as NSSID. The preoccupation with NSSI (Criterion C of NSSID in DSM-5) may as well be imagery-based.

Registration

The study was retrospectively registered with the DRKS under the number DRKS00011854.
Use of antidepressants and benzodiazepine-related hypnotics before and after initiation of TNF-α inhibitors or non-biological systemic treatment in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis
Authors: Brenner Philip , Citarella Anna , Wingård Louise , Sundström Anders
Published: February 2020

Background

Rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are autoimmune disorders associated with an increased risk for depression, anxiety and sleeping problems. The objective of this study was to analyze use of antidepressants and benzodiazepine-related hypnotics (BRH) in Sweden before and after first time treatment with anti-TNF and non-biological systemic (NBS) treatments among patients with the above diagnoses, and to correlate such use with that of randomly selected population controls.

Methods

Patients and dispensed drugs were identified in nationwide Swedish healthcare registers. Proportions of subjects filling prescriptions of antidepressants and BRH from 2 years before start of treatment (index-date), and 2 years after index date were assessed. Using the period -6 months to index-date as reference, prevalence rate ratios were computed for 6 months’ intervals before and after index. For up to ten randomly selected population controls per patient, the same measures were calculated.

Results

A total of 6256 patients started anti-TNF treatment, and 13,241 NBS treatment. The mean age at index was 52.0 for the anti-TNF group and 56.1 for NBS. Use of antidepressants and BRH was similar in both treatment groups (10.4–12.8%), significantly more common than in the controls (6.6 to 7.6%). For all patients, proportions filling prescriptions for antidepressants and BRH decreased directly or soon after the index; no such changes were seen in the controls, who all showed a slow but steady increase in use over time. Starters of anti-TNF treatment did not show clearer decreases in use of psychotropics than those initiating NBS.

Conclusions

Decreased rates of dispensed psychotropic drugs after the time of anti-TNF and NBS treatment initiation were seen among patients with autoimmune disorders but not population controls. This may correspond to treatment effects of anti-TNF and NBS also on psychiatric symptoms among these patients.
Superstructure-based process synthesis and economic assessment under uncertainty for solid drug product manufacturing
Authors: Matsunami Kensaku , Sternal Fabian , Yaginuma Keita , Tanabe Shuichi , Nakagawa Hiroshi , Sugiyama Hirokazu
Published: February 2020

This paper presents a new method for process synthesis and economic assessment for solid drug product manufacturing, considering continuous manufacturing as a prominent process alternative. Of the three phases of drug development, phase II was targeted where the dosage form, formulation, and processing technology are determined. For a comprehensive alternative generation, a superstructure was developed that covered 9452 options for the unit level, which was combined with two options on the formulation strategy. The generated alternative was assessed by a net present value calculation model, which was adapted for dynamic cash flow consideration in the drug lifecycle. The model can incorporate uncertainty in the drug development and manufacturing in the result, and can perform global sensitivity analysis by Monte Carlo simulation. The method was demonstrated in a case study where two different scenarios regarding the price of the active pharmaceutical ingredient and the demand for the product were assumed. The results showed that when the demand and price are both low, the labor-related costs are dominant, and in the opposite case, the material-related costs become relevant. We also introduce the prototype version of the software “SoliDecision,” by which the presented method was implemented for industrial application.
Sparse magnetic vector inversion in spherical coordinates
Authors: Fournier Dominique , Heagy Lindsey J. , Oldenburg Douglas W.
Published: February 2020

Magnetic vector inversion (MVI) has received considerable attention over recent years for processing magnetic field data that are affected by remanent magnetization. However, the magnetization models obtained with current inversion algorithms are generally too smooth to be easily interpreted geologically. To address this, we have reviewed the MVI formulated in a spherical coordinate system. We tackle convergence issues posed by the nonlinear transformation from Cartesian to spherical coordinates by using an iterative sensitivity weighting approach and a scaling of the spherical parameters. The spherical formulation allows us to impose sparsity assumptions on the magnitude and direction of magnetization independently and, as a result, the inversion recovers simpler and more coherent magnetization orientations. The numerical implementation of our algorithm on large-scale problems is facilitated by discretizing the forward problem using tiled octree meshes. All of our results are generated using the open-source SimPEG software. We determine the enhanced capabilities of our algorithm on a large airborne magnetic survey collected over the Kevitsa Ni-Cu-platinum group elements (PGE) deposit. The recovered magnetization direction inside the ultramafic intrusion and in the host stratigraphy is consistent with laboratory measurements and provides evidence for tectonic deformation.
Definition of the Churchill River Delta and its petroleum potential, offshore Labrador, Canada
Authors: Gillis Erin , Wright Richard , Mitchell Victoria , Montevecchi Nick
Published: February 2020

Starting in 2011, a multiyear modern 2D long offset broadband seismic survey was acquired offshore Labrador, Canada, by TGS and PGS in partnership with Nalcor Energy. This regional survey covers the slope and deepwater portions of the margin. Three Mesozoic and Cenozoic-aged basins were informally defined from these data, the Chidley, Henley, and Holton; also, the poorly constrained Hawke Basin was remapped. The 2D data set imaged for the first time a very large Cenozoic-aged delta adjacent to the mouth of Lake Melville. We have mapped this delta on a [Formula: see text] 2D seismic grid. The delta is 5–8 km thick, and its aerial extent is [Formula: see text]. The age of this delta has been interpreted to be Eocene to Miocene. Adjacent to this Cenozoic delta on the Labrador shelf, there is a working petroleum system within the proximal Hopedale and Saglek Basins where there are five gas discoveries and one oil discovery. The modern long-offset 2D data set appears to indicate a working petroleum system within the newly mapped Cenozoic delta, and two phases of hydrocarbons may be present.
Osteoarthritis, Osteophytes, and Enthesophytes Affect Biomechanical Function in Adults With X-linked Hypophosphatemia
Authors: Steele Amy , Gonzalez Ramon , Garbalosa Juan C , Steigbigel Keith , Grgurich Tania , Parisi Erika J , Feinn Richard S , Tommasini Steven M , Macica Carolyn M
Published: February 2020

Context

X-Linked hypophosphatemia (XLH) is a lifelong metabolic disease with musculoskeletal comorbidities that dominate the adult clinical presentation.

Objective

The adult XLH disorder has yet to be quantified on the basis of the physical and functional limitations that can affect activities of daily living. Our goal was to report the impact of the musculoskeletal manifestations on physical function.

Design and setting

Musculoskeletal function was evaluated by validated questionnaires and in an interdisciplinary clinical space where participants underwent full-body radiologic imaging, goniometric range of motion (ROM) measurements, general performance tests, and kinematic gait analysis.

Patients

Nine adults younger than 60 years with a diagnosis of XLH and self-reported musculoskeletal disability, but able to independently ambulate, were selected to participate. Passive ROM and gait analysis were also performed on age-approximated controls to account for differences between individual laboratory instrumentation.

Results

Enthesophytes, degenerative arthritis, and osteophytes were found to be consistently bilateral and diffusely present at the spine and synovial joints across participants, with predominance at weight-bearing joints. Passive ROM in adults with XLH was decreased at the cervical spine, hip, knee, and ankle compared to controls. Gait analysis relative to controls revealed increased step width, markedly increased lateral trunk sway, and physical restriction at the hip, knees, and ankle joints that translated into limitations through the gait cycle.

Conclusions

The functional impact of XLH musculoskeletal comorbidities supports the necessity for creating an interprofessional health-care team with the goal of establishing a longitudinal plan of care that considers the manifestations of XLH across the lifespan.
Efficacy and Safety of Magnesium for the Management of Chronic Pain in Adults: A Systematic Review
Authors: Park Rex , Ho Anthony M.-H. , Pickering Gisele , Arendt-Nielsen Lars , Mohiuddin Mohammed , Gilron Ian
Published: February 2020

Chronic pain is a highly prevalent and complex health problem that is associated with a heavy symptom burden, substantial economic and social impact, and also, very few highly effective treatments. This review examines evidence for the efficacy and safety of magnesium in chronic pain. The previously published protocol for this review was registered in International Prospective Register of Systematic Reviews (PROSPERO), MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched until September 2018. We included randomized controlled trials (RCTs) comparing magnesium (at any dose, frequency, or route of administration) with placebo using participant-reported pain measures. A total of 9 RCTs containing 418 participants were included. Three studies examined neuropathic pain (62 participants), 3 examined migraines (190 participants), 2 examined complex regional pain syndrome (86 participants), and 1 examined low back pain with a neuropathic component (80 participants). Heterogeneity of included studies precluded any meta-analyses. No judgment could be made about safety because adverse events were inconsistently reported in the included studies. Evidence of analgesic efficacy from included studies was equivocal. However, reported efficacy signals in some of the included trials provide a rationale for more definitive studies. Future, larger-sized trials with good assay sensitivity and better safety assessment and reporting, as well as careful attention to formulations with optimal bioavailability, will serve to better define the role of magnesium in the management of chronic pain.
Conditional Survival After Resection for Pancreatic Cancer: A Population-Based Study and Prediction Model
Authors:   for the Dutch Pancreatic Cancer Group, Latenstein Anouk E. J. , van Roessel Stijn , van der Geest Lydia G. M. , Bonsing Bert A. , Dejong Cornelis H. C. , Groot Koerkamp Bas , de Hingh Ignace H. J. T. , Homs Marjolein Y. V. , Klaase Joost M. , Lemmens Valery , Molenaar I. Quintus , Steyerberg Ewout W. , Stommel Martijn W. J. , Busch Olivier R. , van Eijck Casper H. J. , van Laarhoven Hanneke W. M. , Wilmink Johanna W. , Besselink Marc G.
Published: February 2020

Background

Conditional survival is the survival probability after already surviving a predefined time period. This may be informative during follow-up, especially when adjusted for tumor characteristics. Such prediction models for patients with resected pancreatic cancer are lacking and therefore conditional survival was assessed and a nomogram predicting 5-year survival at a predefined period after resection of pancreatic cancer was developed.

Methods

This population-based study included patients with resected pancreatic ductal adenocarcinoma from the Netherlands Cancer Registry (2005–2016). Conditional survival was calculated as the median, and the probability of surviving up to 8 years in patients who already survived 0–5 years after resection was calculated using the Kaplan–Meier method. A prediction model was constructed.

Results

Overall, 3082 patients were included, with a median age of 67 years. Median overall survival was 18 months (95% confidence interval 17–18 months), with a 5-year survival of 15%. The 1-year conditional survival (i.e. probability of surviving the next year) increased from 55 to 74 to 86% at 1, 3, and 5 years after surgery, respectively, while the median overall survival increased from 15 to 40 to 64 months at 1, 3, and 5 years after surgery, respectively. The prediction model demonstrated that the probability of achieving 5-year survival at 1 year after surgery varied from 1 to 58% depending on patient and tumor characteristics.

Conclusions

This population-based study showed that 1-year conditional survival was 55% 1 year after resection and 74% 3 years after resection in patients with pancreatic cancer. The prediction model is available via www.pancreascalculator.com to inform patients and caregivers.
Surgeons’ Ability to Predict the Extent of Surgery Prior to Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy
Authors: Hentzen Judith E. K. R. , van der Plas Willemijn Y. , Been Lukas B. , Hoogwater Frederik J. H. , van Ginkel Robert J. , van Dam Gooitzen M. , Hemmer Patrick H. J. , Kruijff Schelto
Published: February 2020

Background

The extent of surgery (ES) during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) is a well-known risk factor for major postoperative morbidity. Interestingly, the reliability of surgeons to predict the ES prior to CRS + HIPEC is unknown.

Methods

In this prospective, observational cohort study, five surgeons predicted the ES prior to surgery in all consecutive patients with peritoneal metastases (PM) who were scheduled for CRS + HIPEC between March 2018 and May 2019. After the preoperative work-up for CRS + HIPEC was completed, all surgeons independently predicted, for each individual patient, the resection or preservation of 22 different anatomical structures and the presence of a stoma post-HIPEC according to a standardized ES form. The actual ES during CRS + HIPEC was extracted from the surgical procedure report and compared with the predicted ES. Overall and individual positive (PPV) and negative predictive values (NPV) for each anatomical structure were calculated.

Results

One hundred and thirty-one ES forms were collected from 32 patients who successfully underwent CRS + HIPEC. The number of resections was predicted correctly 24 times (18.3%), overestimated 57 times (43.5%), and underestimated 50 times (38.2%). Overall PPVs for the different anatomical structures ranged between 33.3 and 87.8%. Overall, NPVs ranged between 54.9 and 100%, and an NPV > 90% was observed for 12 anatomical structures.

Conclusions

Experienced surgeons seem to be able to better predict the anatomical structures that remain in situ after CRS + HIPEC, rather than predict the resections that were necessary to achieve a complete cytoreduction.
Clinical versus Functional Reaction Time: Implications for Postconcussion Management
Authors: LEMPKE LANDON B. , JOHNSON RACHEL S. , SCHMIDT JULIANNE D. , LYNALL ROBERT C.
Published: February 2020

Purpose

This study aimed to examine the association between clinical and functional reaction time (RT) assessments with and without simultaneous cognitive tasks among healthy individuals.

Methods

Participants (n= 41, 49% female; 22.5 ± 2.1 yr; 172.5 ± 11.9 cm; 71.0 ± 13.7 kg) completed clinical (drop stick, Stroop) and functional (gait, jump landing, single-leg hop, anticipated cut, unanticipated cut) RT assessments in random order. All RT assessments, except Stroop and unanticipated cut, were completed under single- (movement only) and dual-task conditions (movement and subtracting by 6s or 7s). Drop stick involved catching a randomly dropped rod embedded in a weighted disk. Stroop assessed RT via computerized neurocognitive testing. An instrumented walkway measured gait RT when center-of-pressure moved after random stimulus. All other functional RT assessments involved participants jumping forward and performing a vertical jump (jump landing), balancing on one leg (single-leg hop), or a 45° cut in a known (anticipated cut) or unknown (unanticipated cut) direction. RT was determined when the sacrum moved following random visual stimulus. Pearson correlation coefficients and a 5 × 2 repeated-measures ANOVA compared RT assessments and cognitive conditions.

Results

Stroop RT outcomes did not significantly correlate with functional RT assessments (rrange = −0.10 to 0.24). A significant assessment by cognitive task interaction (F4,160= 14.01;P< 0.001) revealed faster single-task RT among all assessments compared with dual-task (mean differences, −0.11 to −0.09 s;P< 0.001), except drop stick (P= 0.195). Single-leg hop (0.58 ± 0.11 s) was significantly slower compared with jump landing (0.53 ± 0.10 s), anticipated cut (0.49 ± 0.09 s), gait (0.29 ± 0.07 s), and drop stick (0.21 ± 0.03 s;Pvalues ≤ 0.001). Dual-task assessments were significantly slower than single-task assessments (mean difference, 0.08 s;P< 0.001).

Conclusions

Clinical and functional RT assessments were not correlated with each other, suggesting that sport-like RT is not being assessed after concussion. Functional and dual-task RT assessments may add clinical value and warrant further exploration after concussion.
STUDI EVALUASI PROGRAM EMPAT BULAN LULUS IQRA JILID 1-6 DI SD MUHAMMADIYAH AMBARKETAWANG 3 YOGYAKARTA
Authors: Gesang Anik Oktavia , Rofiah Nurul Hidayati
Published: February 2020

The research aims to find out the evaluation result of the implementation of four months program of Iqra pass, to know the supporting and inhibiting factors, and to know the follow up plan of the implementation of the four month program pass Iqra. The research used is evaluative research with descriptive data analysis method. Research subjects are principal, teacher coordinator of program implementer. The research was conducted at SD Muhammadiyah Ambarketawang 3 Yogyakarta by using interview, observation, and documentation. Validity of data using credibility test that is using triangulation of source and technique.The results showed the four-month program Iqra graduated successfully and performed quite well. Supporting factors in the implementation of the program include student activeness, contributions of principals, teachers, learning facilities are quite good, as well as sufficient program funds. As for the inhibiting factors is the lack of parental participation and differences in ability of each child. Based on these results, the four-month Iqra program can be continued by performing several improvements such as in terms of infrastructure, the use of Iqra teaching guidance, and improvements related to the contribution of parents to the program.
PERAN PENDIDIKAN DALAM PROSES PEMBELAJARAN INKLUSIF (STUDI KASUS DI SD MUHAMMADIYAH DADAPAN KABUPATEN SLEMAN)
Authors: Banati Arum Umamil , Rofiah Nurul Hidayati
Published: February 2020

Inclusive learning is to provide a service system for children with special needs to be served in the nearest school or regular school with their peers. In the implementation of inclusive learning in schools requires serious handling from related parties, especially parents, the school, government and the community. Therefore, researchers want to know how the role of educators in the inclusive learning process in SD Muhammadiyah Dadapan Sleman District. This research is a qualitative research with descriptive approach of case study. The subject of this research is principal, classroom teacher, subject teacher, special tutor and student. Target object in this research is the role of educator (classroom teacher, special tutor, and children with special needs) in inclusive learning at SD Muhammadiyah Dadapan, Sleman District.Based on the research results obtained conclusions as follows: (1) Educators referred to in this study are classroom teachers, special tutors and subject teachers. The role of special mentor teachers is only as a consultant if the class teacher has difficulty in guiding students with special needs during the learning process in the classroom. The role of classroom teachers and subject teachers is crucial in the inclusive learning process, in schools because students with special needs are more often guided by classroom teachers and subject teachers. (2) Competent educators will be better able to create an effective, enjoyable learning environment, and will be better able to manage the class, so that learning can run optimally. To create a conducive learning atmosphere the educator must have 4 competencies, namely pedagogic competence, personality competence, social competence, and professionalism.
PERILAKU ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) DALAM PROSES PEMBELAJARAN (STUDI KASUS PESERTA DIDIK) DI KELAS IV SD NEGERI GEJAYAN
Authors: Wakhaj Nugrahini Indra Umratun , Rofiah Nurul Hidayati
Published: February 2020

The behavior of primary school-age students today is very diverse, one of these behaviors are children who are very difficult to manage, can not be silent and as if not paying attention to the lessons in the classroom. These children usually experience emotional and behavioral disorders in its development of ADHD (Attention Deficit Hyperactivity Disorder). This study aims to describe the behavior and impact of Attention Deficit Hyperactivity Disorder (ADHD) in the learning process in grade 4 students of SD Negeri Gejayan.This type of research is a type of Descriptive Qualitative research, with data collection techniques of observation, interview, and doumentation. The subjects in this research are DA fourth graders of SD Negeri Gejayan. While the data analysis techniques using data reduction, data presentation, and conclusions.The results showed that there was Attention Deficit Hyperactivity Disorder (ADHD) behavior in the learning process in Grade IV of Gejayan State Elementary School which consisted of three behaviors: inattensi, hyperactive and impulsive behavior. The impact of Attention Deficit Hyperactivity Disorder (ADHD) behavior affects three aspects including (1) impact on learning process or education, (2) impact on student's behavior in learning process and, (3) impact to social aspect of student in process learning.
PERAN ORANGTUA DALAM PENANAMAN TANGGUNGJAWAB PADA SISWA SD MUHAMMADIYAH AMBARKETAWANG 2 GAMPING
Authors: Nurmasita Nurmasita , Rofiah Nurul Hidayati
Published: February 2020

Based on the results of observations and interviews to classroom teachers conducted by researchers there are still students who are less focused in listening to the ongoing learning process, there are children who, when given an individual task by the teacher who then asked for answers to his friends, often students do the task no maximum and if given the task of the house did not complete. This research aims to Describe the role of parents in planting responsibilities, and describe the factors that support and hinder the cultivation of responsibility to students.The type of research is descriptive qualitative research type, with observation and interview data collection techniques while data analysis techniques using data reduction, presentation of data and conclusions and while the validity of the data used is triangulation techniques and triangulation of sources. The result of the research is the role of parents in the planting of responsibilities on the students of SD Muhammadiyah Ambarketawang 2 Gamping has implemented a good planting system in the form of motivation or support, meet the needs of children ranging from clothing, food and student boards, and be a mediator of children both in the scope of school and space the scope of the house and the contributing factors to the planting of responsibilities to the students is that there are some parents and who assume the character of responsibility is very important for the child by applying the punishment to the child if the child does not respond to the advice or motivation of the parents or teachers, and the assignment to the students is also applied by the teacher during the learning process takes place, and the inhibiting factor on planting the character of responsibility is the busyness of the working parents so that the time given to the child is slightly reduced
PENGEMBANGAN LEMBAR KERJA SISWA (LKS) BERBASIS CONTEXTUAL TEACHING AND LEARNING DI LINGKUNGAN SEKOLAH PADA MATA PELAJARAN IPA KELAS III SD MUHAMAMDIYAH PAKEL PROGRAM PLUS YOGYAKARTA
Authors: P Brahmantara Ihsan , Hidayat Panji
Published: February 2020

The research background is caused by students tend to feel bored when learning science. This study aims to develop LKS teaching materials based on Contextual Teaching and Learning in the school environment for science subjects for grade III elementary school, and to determine the feasibility of LKS teaching materials based on Contextual Teaching and Learning developed. This study uses the Research and Develpoment (R & D) method which was adapted from Sugiyono's research. The teaching materials developed through media expert validation, material expert validation, and learning expert validation. Then it was tested at Pakel Muhammadiyah Elementary School Yogyakarta Plus Program by using small group and large group trials. The research was carried out in accordance with the planned steps, in accordance with the development model adapted from Sugiyono's research, resulting in Contextual Teaching and Learning-based LKS teaching materials in the school environment on science subjects material for maintaining environmental health around class III SD Muhammadiyah Pakel Plus Program Yogyakarta, learning can be more effective. The evaluation data for teaching materials developed are as follows: media experts get a percentage of 93.3% in very decent criteria, material experts get a percentage of 81.67% in very feasible criteria, learning experts get a percentage of 80% in eligible criteria, small group trials the percentage of 91.1% is very feasible, the large group trial gets a percentage of 97.82% which is very feasible, the assessment of the small group trial teacher gets a percentage of 98.3% and is very feasible, and the assessment of large group testing teachers get a percentage of 100% which is very feasible. Based on these data, LKS teaching materials based on Contextual Teaching and Learning developed are appropriate for use in the learning process.
PERAN KEPALA SEKOLAH DALAM MENGEMBANGKAN KULTUR SEKOLAH DI SD MUHAMMADIYAH SANGONAN 2
Authors: Ilmasari Fahmadinna , Alhadi Said
Published: February 2020

ABSTRACT                This study aims to answer: 1) the role of school principals in developing school culture in Muhammadiyah Sangonan Elementary School 2, 2) supporting factors and obstacles for school principals in developing school culture in SD Muhammadiyah Sangonan 2.This type of research uses descriptive qualitative research. The subjects of this study were principals, teachers and students. Data collection techniques using triangulation techniques and sources. Data analysis techniques using interactive data models Miles and Huberman.The results of the study are as follows: 1) the role of the principal in developing school culture through 4 roles namely the role of the principal as manager, the role of the principal as leader, the role of the principal as an innovator and the role of the principal as motivator. The role of the principal as a manager includes the principal taking actions or efforts taken to develop school coursework (compiling the program), joint efforts of the teacher in developing a better school culture, mobilizing teachers to take part in implementing the developed school culture. Keywords: School Culture and the Role of Principals.
PENGEMBANGAN MEDIA CORONG HITUNG UNTUK MENINGKATKAN KETERAMPILAN BERHITUNG TENTANG OPERASI BILANGAN PADA SISWA KELAS I SEKOLAH DASAR
Authors: Noer Pratiwi Rosita , Anggit Prabowo
Published: February 2020

Development of Funnel Counting media is very necessary because there is no learning media that can help students learn about number operations. This condition has an impact on students' numeracy skills which are still low. To overcome this problem there needs to be an appropriate solution. One of them is by developing media that attract students in the form of a Calculating Funnel media. This study aims to determine the steps for developing and the feasibility of media Counting Funnels. This research is research and development (R & D) with the development model of 4D (Four-D), namely Define, Design, Development, Disseminate. The subject of this study was the first grade students of SD Muhammadiyah Bleber with a total of 18 students. The instruments of data collection are questionnaires, interview guides, tests, and documents. The data analysis technique used is qualitative analysis and quantitative analysis. The results of validation research media experts get a value of 93.75 (Very Good), validation of material experts get 85.41 (Very Good), validation of learning experts get 85.41 (Very Good), the results of expert validation get comments and suggestions as a reference for doing product revision. The results of a small group trial with 8 students scored 87.50 (very good). The teacher's assessment received a score of 94.11 (very good). Student responses got a value of 95.83 (very good). While the usage trial with 18 students got a value of 86.50 (very good). The teacher's response to the use trial received a score of 97.50 (very good). students' responses get a score of 97.50 (very good). Overall, from the Funnel Counting media validation test, it is feasible to use it in grade 1 elementary mathematics learning.
IMPLEMENTASI PROGRAM GERAKAN LITERASI SEKOLAH (GLS) DITINJAU DARI TAHAP PENGEMBANGAN DI SD UNGGULAN AISYIYAH BANTUL
Authors: Triaryanti Hanika , Hidayah Nur
Published: February 2020

Penelitian ini bertujuan untuk mengetahui Implementasi program Gerakan Literasi Sekolah (GLS) ditinjau dari Tahap Pengembangan di SD Unggulan Aisyiyah Bantul. Jenis penelitian ini adalah deskriptif kualitatif. Subjek penelitian adalah kepala sekolah, beberapa guru kelas, dan beberapa peserta didik secara acak. Objek penelitian adalah segala hal terkait program Gerakan Literasi Sekolah (GLS) tahap pengembangan di SD Unggulan Aisyiyah Bantul. Teknik pengumpulan data yang digunakan meliputi observasi, wawancara, dan dokumentasi. Data dianalisis dengan menggunakan model Miles and Huberman. Keabsahan data dilakukan dengan triangulasi sumber, triangulasi teknik, dan triangulasi waktu. Hasil penelitian menunjukkan: Implementasi program Gerakan Literasi Sekolah (GLS) pada tahap pengembangan sudah berjalan baik, adapun terdapat tahapan (1) Perencanaan, yaitu sekolah membuat Tim Literasi Sekolah untuk menyusun Rencana Kerja Tahunan berkaitan dengan literasi (2) Pelaksanaan, meliputi pembuatan pojok baca, pemilihan buku bacaan, pembiasaan membaca dan menulis, pemanfaatan perpustakaan, penghargaan peserta didik, menciptakan lingkungan kaya teks, lomba literasi, dan perlibatan publik, (3) Evaluasi, meliputi ketercapaian, faktor pendukung dan penghambat, serta keberlanjutan program literasi.
IMPLEMENTASI PENANAMAN KARAKTER RELIGIUS MELALUI BUDAYA SEKOLAH DI SD MUHAMMADIYAH KARANGPLOSO
Authors: Ariwibowo Utami , Saifudin Muhamad Fakhrur
Published: February 2020

This study aims to describe and find out the factors supporting and inhibiting the implementation of religious character education through school culture in SD Muhammadiyah Karangploso. The background of this research is the implementation of character education that has not been maximally applied in Indonesia. The school emphasizes verbal and numerical abilities while the ability to instill faith and piety is ignored. Muhammadiyah Karangploso Elementary School is an elementary school that seeks to instill religious character. These efforts are in line with the vision of the school that is the realization of Muslim people who have noble, intelligent, skilled, independent, noble culture, useful for society and the country. This type of research is descriptive research 'using a qualitative approach. Research subjects are the principal, teachers, and students. The object of this research is the whole process of activities regarding the implementation of religious character planting through school culture in SD Muhammadiyah Karangploso. The results showed that Muhammadiyah Karangploso Elementary School had implemented religious character planting well, and referred to indicators of success according to the Ministry of National Education and expert opinion but there were still obstacles related to its implementation including environmental conditions of students who were not friendly so that it had an impact on the way students behaved.
HUBUNGAN PENDEKATAN LINGKUNGAN ALAM SEKITAR (PLAS) DENGAN HASIL BELAJAR SISWA KELAS V SEKOLAH DASAR
Authors: Suprapto Hidayah Mulyaningsih
Published: February 2020

This study aims to determine the relationship between the approach of the natural environment with the learning outcomes of students in grade V SD N 3 Klaten Grabag Magelang. The learning that is happening now has increased material that is taught increasingly difficult how to teach teachers is still conventional lack of media and facilities learning especially in natural science learning that requires concrete understanding.  For this reason teachers need to innovate in learning one of them using the natural environment approach that can be used in science subjects.  The subjects of this study were students of grade V SD N 3 Klaten as many as 32 children 16 children of the experimental group and 16 control groups selected by the object random sampling system in this study were natural science learning outcomes using a natural environment approach around data collection techniques used in the form of observation and documentation. this type of research is a quasi-experimental with pretest posttest control group design research method used is quantitative data analysis techniques in this study using t test with a significance level of 5%. The results of the study showed that the experimental group obtained the calculated thitung (7,580) > t tabel(df:15) (2,145),  and the p (0,000) < dari 0,05 value with the results of the study meant that there was an increase in student learning outcomes in grade V SD N 3 Klaten using a significant natural environment approach to student learning outcomes so that it could be concluded that there was a significant relationship between the approaches  the surrounding natural environment with student learning outcomes in the material Adjustment of living things with the environment in grade V SD Negeri 3 Klaten Grabag Magelang.