bluuebunny/crossref_metadata_2025 huggingface dataset:
Lupus Gastrointestinal Tract Vasculopathy: Lupus “Enteritis” Involving the Entire Gastrointestinal Tract from Esophagus to Rectum
Authors: Bert Joseph , Gertner Elie
Published: February 2017

Gastrointestinal symptoms are very common in systemic lupus erythematosus (SLE). Lupus “enteritis” is very responsive to treatment but can have devastating consequences if not detected. Most descriptions of enteritis involve the small and large bowel. This is the first report of lupus “enteritis” involving the entire gastrointestinal tract from the esophagus and stomach to the rectum. Lupus “enteritis” is another cause of upper gastrointestinal involvement in SLE (involving even the esophagus and stomach) in addition to involvement of the lower intestinal tract.
Iodine-125 Brachytherapy for Uveal Melanoma: A Systematic Review of Radiation Dose
Authors: Echegaray Jose J. , Bechrakis Nikolaos E. , Singh Nakul , Bellerive Claudine , Singh Arun D.
Published: February 2017

Aim: To investigate whether lower radiation doses may yield similar outcome measures to those from the COMS trial. Methods: A literature review of English language articles was performed using the PubMed database of the U.S. National Library of Medicine and the Cochrane Central Register of Controlled Trials using the following keywords: uveal melanoma, choroidal melanoma, primary uveal malignant melanoma, iodine-125 brachytherapy, local recurrence, local treatment failure, and local tumor control. The relationships between study local recurrence rate and median dosage were tested by linear regression, with each study weighted by the number of patients included. Results: Fifteen retrospective and prospective studies were selected for systematic review (2,662 patients). Ranges of reported mean or median radiation dose to tumor apex were 62.5-104.0 Gy. Local recurrence rates ranged from 0 to 24%. A 1.0-Gy increase in the average study dose was associated with a 0.14% decrease in local recurrence rate, which was not statistically significant (p value 0.336). Conclusion: The gold standard empirically derived 85.0-Gy radiation dose for the treatment of uveal melanoma could be tested in a randomized study.
Feasibility and Safety of a Transthoracic Pneumostoma Airway Bypass in Severe Emphysema Patients
Authors: Snell Gregory I. , Holsworth Lynda , Khorramnia Sadie , Westall Glen P. , Williams Trevor J. , Marasco Silvana , Gooi Julian H.
Published: February 2017

Background: Emphysema is characterised by airflow obstruction, hyperinflation, and resultant dyspnoea. It is worth investigating whether decompression improves lung mechanics and enhances quality of life (QoL). Objectives: The purpose of this study was to describe the feasibility and safety of creating a transthoracic pneumostoma to enable lung reduction. Methods: A transthoracic 10-mm diameter Portaero Access Tube (Portaero™, Cupertino, CA, USA) was implanted via a third intercostal space incision in 15 severe emphysema patients [mean age 63 years, forced expiratory volume in 1 s 54% predicted, diffusing capacity for carbon monoxide 31% predicted, residual volume 246% predicted, Six-Minute Walk Test 296 m]. Four weeks later, an 8-mm Portaero Disposable Tube (3-8 cm in length) was substituted and changed daily thereafter. The targeted primary endpoints were a ≥12% increase in forced expiratory volume in 1 s and a decrease of ≥4 points in Saint George's Respiratory Questionnaire score at 6 months. Results: Sixteen procedures were performed on 15 patients, complicated by 1 intercostal haemorrhage, 1 pneumothorax, and universal mild surgical emphysema. Early patency issues were common, but often responded to external endoscopic debridement or argon plasma laser. Three-month patency was achieved in 9 of 15 patients, and 6 of these had long-term patency (mean of 4 years). Patency was associated with potentially useful long-term improvements or stability in spirometry, residual volume, and QoL. However, the primary endpoints were not met at 6 months. Conclusion: The creation and maintenance of a transthoracic pneumostoma appears feasible and safe in patients with severe emphysema. Further studies refining patient selection (perhaps via chest computed tomography collateral ventilation and fissure assessments), techniques, and tube materials are suggested.
Clinical Value of the Epstein-Barr Virus and p16 Status in Patients with Nasopharyngeal Carcinoma: A Single-Centre Study in Japan
Authors: Saito Yuki , Ushiku Tetsuo , Omura Go , Yasuhara Kazuo , Yoshida Masafumi , Takahashi Wataru , Ando Mizuo , Fukayama Masashi , Yamasoba Tatsuya
Published: February 2017

Background: The clinical significance of the Epstein-Barr virus (EBV) status and p16 expression was unknown in nasopharyngeal carcinoma (NPC). Methods: We retrospectively studied our pathology database for 13 years to determine the prevalence of EBV and p16 expression and their association with prognosis in cases of NPC. We performed immunohistochemistry for the p16 protein and in situ hybridization (ISH) for EBV-encoded small RNAs and human papillomavirus (HPV) DNA. Results: Of the 43 patients with NPC, 27 (63%), 6 (14%), and 10 (23%) cases were EBV positive, EBV negative with keratinization, and EBV negative without keratinization, respectively. No cases were HPV positive by ISH. Among the 21 EBV-positive tumours that were tested for p16, only 2 tumours were p16 positive. The keratinization-positive group included only males, typically >60 years of age (5 of 6) and with T4 tumours (3 of 6). In contrast, the EBV-positive cohort tended to be younger (<60 years, 13 of 27) and have progressive N-stage tumours (N2-3, 14 of 27). The keratinization and EBV-negative cohort included predominantly males (9 of 10) who were likely p16 negative (4 of 10) and smokers (7 of 10). Multivariate analysis confirmed that keratinization was an independent prognostic factor for progression-free survival. Conclusion: In areas, such as Japan, that are nonendemic for both EBV and HPV, the causality of NPC appears to be more heterogeneous.
Enantioselective Effect of Flurbiprofen on Lithium Disposition in Rats
Authors: Uwai Yuichi , Matsumoto Masashi , Kawasaki Tatsuya , Nabekura Tomohiro
Published: February 2017

Aims: Lithium is administered for treating bipolar disorders and is mainly excreted into urine. Nonsteroidal anti-inflammatory drugs inhibit this process. In this study, we examined the enantioselective effect of flurbiprofen on the disposition of lithium in rats. Methods: Pharmacokinetic experiments with lithium were performed. Results: Until 60 min after the intravenous administration of lithium chloride at 30 mg/kg as a bolus, 17.8% of lithium injected was recovered into the urine. Its renal clearance was calculated to be 1.62 mL/min/kg. Neither creatinine clearance (Ccr) nor pharmacokinetics of lithium was affected by the simultaneous injection of (R)-flurbiprofen at 20 mg/kg. (S)-flurbiprofen impaired the renal function and interfered with the urinary excretion of lithium. The ratio of renal clearance of lithium to Ccr was decreased by the (S)-enantiomer. Conclusion: This study clarified that the (S)-flurbiprofen but not (R)-flurbiprofen inhibited the renal excretion of lithium in rats.
Hochuekkito, a Japanese Herbal Medicine, Restores Metabolic Homeostasis between Mitochondrial and Glycolytic Pathways Impaired by Influenza A Virus Infection
Authors: Takanashi Keita , Dan Katsuaki , Kanzaki Sho , Hasegawa Hideki , Watanabe Kenji , Ogawa Kaoru
Published: February 2017

Background: Hochuekkito (HKT), a traditional Japanese herbal medicine (Kampo), has been used to treat symptoms of several diseases. In a recent clinical study, HKT was shown to be protective against the influenza virus infection. However, the underlying mechanism of the prophylactic effect is not clear. Mitochondrial and glycolytic pathways play important roles in cellular energy metabolism to maintain biological functions. These metabolic pathways are affected by the influenza virus infection. In this study, we examined the relationship between the preventive effects of HKT against the influenza virus infection and cellular energy metabolism in mitochondria and glycolysis using Madin-Darby canine kidney cells and influenza A/PR/8/34 (H1N1) virus (IAV). Methods: Mitochondrial and glycolytic metabolic pathways were evaluated on the basis of the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR), respectively, using the XF24 Extracellular Analyzer. Results: The OCR/ECAR ratio in IAV-infected cells was lower than that in control cells. Cells that were treated with HKT before IAV infection showed a metabolic pattern similar to that in the control cells (increase in both OCR and ECAR). Conclusions: Our results suggest that HKT not only activates both mitochondrial and glycolytic energy metabolism in IAV-infected cells but also helps maintain metabolic homeostasis similar to that in noninfected cells.
Rationale and Design of a Clinical Trial Investigating Tolvaptan Safety and Efficacy in Autosomal Dominant Polycystic Kidney Disease
Authors: Torres Vicente E. , Devuyst Olivier , Chapman Arlene B. , Gansevoort Ron T. , Perrone Ronald D. , Ouyang John , Blais Jaime D. , Czerwiec Frank S. , Sergeyeva Olga ,   for the REPRISE Trial Investigators
Published: February 2017

Background: In TEMPO 3:4, the vasopressin V2-receptor antagonist tolvaptan slowed kidney growth and function decline in autosomal dominant polycystic kidney disease (ADPKD) patients with relatively preserved kidney function. Methods: Prospective, phase 3b, multi-center, randomized-withdrawal, placebo-controlled, double-blind trial of tolvaptan in ADPKD patients with late stage 2 to early stage 4 chronic kidney disease (CKD). The primary endpoint was estimated glomerular filtration rate (eGFR) change from pre-treatment baseline to post-treatment follow-up. Secondary endpoints included annualized eGFR slope, incidence of ADPKD complications, and overall and hepatic safety profiles. Participants were 18-55 year-old ADPKD patients with baseline eGFR ≥25 and ≤65 mL/min/1.73 m2 or 56-65 year-old with eGFR ≥25 and ≤44 mL/min/1.73 m2 and evidence of eGFR decline >2.0 mL/min/1.73 m2 per year. Daily split doses of tolvaptan were titrated to tolerance (30/15, 45/15, 60/30, or 90/30 mg) and maintained for 12 months, after an 8-week pre-randomization period to screen out subjects unable to tolerate at least 60/30 mg for 3 weeks. Results: Of 1,495 subjects who entered the tolvaptan titration period, 125 (8.4%) discontinued the study before randomization. One thousand three hundred seventy subjects (684 tolvaptan, 686 placebo) from 213 centers across 21 countries were randomized. Baseline demographics were well balanced across treatment arms. Information collected during the study included eGFR, survey scores (PKD history and outcome), adverse events, vital signs, hematology, urinalysis, and serum chemistry tests. Conclusion: Replicating Evidence of Preserved Renal Function: An Investigation of Tolvaptan Safety and Efficacy (REPRISE) determines whether tolvaptan administered over 1 year exhibits disease-modifying properties in ADPKD patients with late stage 2 to early stage 4 CKD, which provides an important therapeutic advancement for this difficult-to-treat disease.
Regulatory Role of miRNA-375 in Expression of BMP15/GDF9 Receptors and its Effect on Proliferation and Apoptosis of Bovine Cumulus Cells
Authors: Chen Hongyan , Liu Chang , Jiang Hao , Gao Yan , Xu Mingqiang , Wang Jiawei , Liu Siyuan , Fu Yao , Sun Xulei , Xu Jiajun , Zhang Jiabao , Dai Lisheng
Published: February 2017

Background: Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are members of the transforming growth factor beta (TGF-β) superfamily. Through autocrine and paracrine mechanisms, these two factors can regulate cell differentiation, proliferation, and other functions in the ovary locally. Furthermore, GDF9 and BMP15 play vital roles in follicular growth, atresia, ovulation, fertilization, reproduction, and maintenance. Numerous studies have demonstrated a synergy between BMP15 and GDF9. Studies in humans and mice have indicated that the synergy between BMP15 and GDF9 is primarily mediated by the bone morphogenetic protein type II receptor (BMPR2). The BMP15/GDF9 heterodimer needs to bind to the BMPR2-ALK4/5/7-ALK6 receptor complex to activate the SMAD2/3 signaling pathway. However, it is not clear which genes mediate and regulate the effects of the BMP15/GDF9 proteins on bovine cumulus cells (CCs). Methods: Our earlier study showed that BMPR2 is a gene that is directly targeted and regulated by miR-375. Therefore, we designed and synthesized an miR-375 mimics/inhibitor and regulated BMPR2 expression in bovine CCs by the overexpression or inhibition of miR-375. After the overexpression or inhibition of miR-375, the apoptosis rate of bovine CCs was measured by flow cytometry; changes in critical gene expression were measured by RT-qPCR and western blot assays; and the proliferation of bovine CCs was measured by CCK-8 assay. Results: In bovine CCs, the overexpression of miR-375 resulted in decreased BMPR2 and ALK7 expression, whereas the inhibition of miR-375 caused increased BMPR2 and ALK7 expression. The overexpression of miR-375 attenuated the proliferation ability and significantly increased the apoptosis rate of bovine CCs, whereas the inhibition of miR-375 did not significantly change the proliferation ability or apoptosis rate. Conclusions: BMPR2, a target of miR-375, is regulated by this molecule, thereby affecting expression of BMP15/GDF9 receptors, and the proliferation and apoptosis of bovine CCs.
Fatty Acid-Binding Protein 4 in Endometrial Epithelium Is Involved in Embryonic Implantation
Authors: Wang Peng , Zhu Qiuyuan , Peng Huilian , Du Mengkai , Dong Minyue , Wang Hanzhi
Published: February 2017

Aims: To clarify the role of fatty acid-binding protein 4 (FABP4) of endometrial epithelial cell in the establishment and maintenance of pregnancy and the involvement in the pathogenesis of pregnancy loss. Methods: The expression of FABP4 and uterine receptive factor (LIF, Integrin-β3 and Claudin 4) was determined by Western blotting or quantitative PCR. FABP4 siRNA was used to silence FABP4 while FABP4 inhibitor was used to inhibit the function of FABP4 in endometrial epithelial cell. ICR mice were raised to evaluate the effect of FABP4 silence or inhibition on embryo implantation in vivo after FABP4 siRNA mixture or inhibitor was injected into uterus, and an embryonic adhesion system using trophoblast spheroids mimicking embryos was set up to assess the effect of FABP4 silence or inhibition on embryonic adhesion onto endometrial cell in vitro. Results: The expression of FABP4 mRNA was significantly decreased in the deciduas of women with pregnancy loss compared with that of women with normal pregnancy. FABP4 siRNA significantly reduced the number of embryos implanted and FABP4 expression in ICR mice. FABP4 inhibition also significantly decreased the number of embryos implanted. Either silence or inhibition of FABP4 in endometrial epithelial cell abolished the expression of uterine receptive factors induced by the combination of estrogen and progesterone-induced, and reduced the number of trophoblast spheroids adhered onto endometrial cell. Conclusions: FABP4 regulates embryo implantation via altering uterine receptivity and decreased expression of FABP4 in endometrium may be linked with pregnancy loss, indicating FABP4 has biological role in the establishment and maintenance of pregnancy and subsequently is involved in pathogenesis of pregnancy loss.
T Cell–Associated Immunotherapy for Hepatocellular Carcinoma
Authors: Ma Weijie , Wu Long , Zhou Fuling , Hong Zhenfei , Yuan Yufeng , Liu Zhisu
Published: February 2017

Hepatocellular carcinoma (HCC) is one of the most common malignant diseases worldwide with limited therapeutic options. Accumulating evidences suggest that immunotherapy could be a promising option for treating HCC. T cell-associated immunotherapy lights up the hope for the improvement of complementary approach to conventional HCC treatments, which needs further research to consummate the clinical consequences. The present work reviewed several T cells associated cellular immunotherapies for HCC, including immune checkpoint blockade, gene–engineered T cells, bispecific T cell engagers, and so on. We also analyzed how these immunotherapies can mediate tumor cell eradication and evaluated their superiority or insufficiency.
The Effect of Selective Transcranial Magnetic Stimulation with Functional Near-Infrared Spectroscopy and Intensive Speech Therapy on Individuals with Post-Stroke Aphasia
Authors: Hara Takatoshi , Abo Masahiro , Kakita Kiyohito , Mori Yuko , Yoshida Makoto , Sasaki Nobuyuki
Published: February 2017

Purpose: To examine the efficacy of selective repetitive transcranial magnetic stimulation (rTMS) therapy guided by functional near-infrared spectroscopy (fNIRS) combined with intensive speech therapy (iST) on post-stroke patients with aphasia. Material and Methods: Eight right-handed patients with aphasia in the chronic stage after stroke were grouped into left and right hemisphere-activated for a language task based on pre-intervention fNIRS. Those with left hemisphere activation received 1-Hz TMS to the right inferior frontal gyrus (RtIFG; low-frequency rTMS [LFS] group), and those with right hemisphere activation received 10-Hz TMS to the RtIFG (high-frequency rTMS [HFS] group). The patients underwent an 11-day program of rTMS and iST. Results: Both groups showed a significant improvement in language function as measured by Standard Language Test of Aphasia (SLTA) total score at post-intervention relative to pre-intervention. Furthermore, the pre-to-post SLTA change scores were not statistically different between the groups. Comparison of pre- and post-intervention fNIRS revealed a resolution of the imbalance of interhemispheric inhibition in the LFS group and activation of the target hemisphere in the HFS group. Conclusions: The administration of fNIRS-guided selective rTMS therapy and iST to post-stroke patients with aphasia induced a significant improvement in language function, with both groups demonstrating a similar degree of improvement.
P38 MAPK Pharmacological Inhibitor SB203580 Alleviates Total Parenteral Nutrition-Induced Loss of Intestinal Barrier Function but Promotes Hepatocyte Lipoapoptosis
Authors: Xiao Yong-Tao , Yan Wei-Hui , Cao Yi , Yan Jun-Kai , Cai Wei
Published: February 2017

Background & Aims: Our previous studies have provided evidence that p38 mitogen-activated protein kinase (MAPK) is involved in total parenteral nutrition (TPN)-associated complications, but its exact effects and mechanisms have not been fully understood. This study aimed to evaluate the roles of p38 MAPK inhibitor SB203580 in the TPN-induced loss of intestinal barrier function and liver disease. Methods: A rodent model of TPN was used to analyze the roles of SB203580 in TPN-associated complications.Intestinal barrier function was evaluated by transepithelial electrical resistance (TER) and paracellular permeability in Caco-2 cells. The palmitic acid (PA) was used to induce hepatic lipoapoptosis in vitro. The lipoapoptosis was detected using Caspase-3/7 and lipid staining. Results: In the present study, we showed that SB203580 treatment significantly suppressed TPN-mediated intestinal permeability in rats. SB203580 treatment significantly inhibited IL-1β-induced an increase in tight junction permeability of Caco-2 cells via repressing the p38/ATF-2 signaling. Unexpectedly, SB203580 treatment enhanced hepatic lipoapoptosis in the model of TPN. Palmitic acid (PA)-induced hepatic lipoapoptosis in human liver cells was significantly augmented by the SB203580 treatment. Conclusions: We demonstrate that the p38 MAPK inhibitor SB203508 ameliorates intestinal barrier function but promotes hepatic lipoapoptosis in model of TPN.
Improved Stator Flux Estimation for Direct Torque Control of Induction Motor Drives
Authors: Alamri Yahya Ahmed , Nik Idris Nik Rumzi , Mohd. Alsofyani Ibrahim , Sutikno Tole
Published: February 2017

Stator flux estimation using voltage model is basically the integration of the induced stator back electromotive force (emf) signal. In practical implementation the pure integration is replaced by a low pass filter to avoid the DC drift and saturation problems at the integrator output because of the initial condition error and the inevitable DC components in the back emf signal. However, the low pass filter introduces errors in the estimated stator flux which are significant at frequencies near or lower than the cutoff frequency. Also the DC components in the back emf signal are amplified at the low pass filter output by a factor equals to . Therefore, different integration algorithms have been proposed to improve the stator flux estimation at steady state and transient conditions. In this paper a new algorithm for stator flux estimation is proposed for direct torque control (DTC) of induction motor drives. The proposed algorithm is composed of a second order high pass filter and an integrator which can effectively eliminates the effect of the error initial condition and the DC components. The amplitude and phase errors compensation algorithm is selected such that the steady state frequency response amplitude and phase angle are equivalent to that of the pure integrator and the multiplication and division by stator frequency are avoided. Also the cutoff frequency selection is improved; even small value can filter out the DC components in the back emf signal. The simulation results show the improved performance of the induction motor direct torque control drive with the proposed stator flux estimation algorithm. The simulation results are verified by the experimental results.
Performance Characteristics of Induction Motor with Field Oriented Control Compared to Direct Torque Control
Authors: Soliman Hamdy Mohamed
Published: February 2017

With development of power electronics and control Theories, the AC motor control becomes easier. So the AC motors are used instead of the DC motor in the drive applications. With this development, a several methods of control are invented. The field oriented control and direct torque control are from the best methods to control the drive systems. This paper is compared between the field oriented control and direct torque control to show the advantages and disadvantages of these methods of controls. This study discussed the effects of these methods of control on the total harmonic distortion of the current and torque ripples. This occurs through study the performance characteristics of the AC motor. The motor used in this study is an induction motor. This study is simulated through the MATLAB program.
Modified SVPWM Algorithm for 3-level Inverter Fed DTC Induction Motor Drive
Authors: Swamy G. Kumara , Obulesu YP
Published: February 2017

In this paper, a modified space vector pulse width modulation (MSVPWM) algorithm is developed for 3-level inverter fed direct torque controlled induction motor drive (DTC-IMD). MSVPWM algorithm  simplifies conventional space vector pulse width modulation (CSVPWM) algorithm for multilevel inverter(MLI), whose complexity lies in sector/subsector/sub-subsector identification; which will commensurate with number of levels. In the proposed algorithm sectors are identified as in two level inverter and subsectors/sub-subsectors are identified by shifting the original reference vector to sector 1 (S1). This is valid due to the fact that a three level space vector plane is a composition of six two level space planes, and are symmetrical with reference to six pivot states. Switching state/sequence selection is also very important while dealing with SVPWM strategy for MLI. In the proposed algorithm out of 27 available switching states apt switching state is selected based on sector and subsector number, such that voltage ripple is considerably less. To validate the proposed algorithm, it is tested on a three level neutral point clamped (NPC) inverter fed DTC-IMD. The performance of the MSVPWM algorithm is analyzed by comparing no load stator current ripple of the three level DTC-IMD with two level DTC-IMD. Significant reduction in steady state torque and flux ripple is observed. Hence, reduced acoustic noise is a distinctive facet of the proposed method.
Modelling of a 3-phase Induction Motor under Open-phase Fault Using Matlab/Simulink
Authors: Jannati Mohammad , Sutikno Tole
Published: February 2017

The d-q model of Induction Motors (IMs) has been effectively used as an efficient method to analyze the performance of the induction machines. This study presents a step by step Matlab/Simulink implementation of a star-connected 3-phase IM under open-phase fault (faulty 3-phase IM) using d-q model. The presented technique in this paper can be simply implemented in one block and can be made available for control purposes. The simulated results provide to show the behavior of the star-connected 3-phase IM under open-phase fault condition.
A Novel Approach to GSA, GA and Wavelet Transform to Design Fuzzy Logic Controller for 1ϕ Multilevel Inverter
Authors: Singh Varsha , Gupta S. , Pattnaik S. , Goyal Aarti
Published: February 2017

This paper proposes a novel approach for obtaining a closed loop control scheme based on Fuzzy Logic Controller to regulate the output voltage waveform of multilevel inverter. Fuzzy Logic Controller is used to guide and control the inverter to synthesize a stepped output voltage waveform with reduced harmonics. In this paper, three different intelligent soft-computing methods are used to design a fuzzy system to be used as a closed loop control system for regulating the inverter output. Gravitational Search Algorithm and Genetic Algorithm are used as optimization methods to evaluate switching angles for different combination of input voltages applied to MLI. Wavelet Transform is used as synthesizing technique to shape stepped output waveform of inverter using orthogonal wavelet sets. The proposed FLC controlled method is carried out for a wider range of input dc voltages by considering ±10% variations in nominal voltage value. A 7-level inverter is used to validate the results of proposed control methods. The three proposed methods are then compared in terms of various parameters like computational time, switching angles and THD to justify the performance and system flexibility. Finally, hardware based results are also obtained to verify the viability of the proposed method.
Comparison of Sine and Space Vector Modulated Embedded Z-source Inverter fed Three Phase Induction Motor Drive System
Authors: Malathi R. , Rathinakumar M.
Published: February 2017

This paper deals with performance of photovoltaic powered Embedded Z-Source Inverter (EZSI) fed Induction motor drive. The DC output from the PV-Panel is boosted and converted into AC using Embedded Z-Source Inverter. EZSI system based on the concept of Z-Source Inverter (ZSI), which provides single stage power conversion. The EZSI also produce same voltage gain as that of the ZSI based system. In EZSI the DC source is embedded within the X-shaped LC impedance network, due to this EZSI has the added advantage of inherent source filtering capability , this can be achieved without any extra passive filter. EZSI can produce the AC output voltage which is greater than the DC link voltage. EZSI system also provides ride-through capability under voltage sags. In this paper the performance of space vector modulated EZSI fed Induction Motor Drive is compared with sinusoidal PWM controlled EZSI fed Drive system. The PV powered EZSI fed three phase Induction Motor System is designed, modeled and simulated using MAT LAB-SIMULINK and the corresponding results are presented. This drive system has advantages like voltage boosting ability and reduced harmonic content.
Performance Analysis of Photovoltaic Induction Motor Drive for Agriculture Purpose
Authors: Raj P R Neethu , V Vasanthi
Published: February 2017

This paper presents water pumping system using renewable source (solar) without the use of chemical storage batteries. In this converter-inverter circuit is used to drive Induction motor. The Converter used here is Two Inductor boost converter (TIBC), which consists of a resonant tank, voltage doubler rectifier and a snubber circuit. TIBC is designed to drive the three phase induction motor from PV energy. TIBC converter is also known as current fed multi resonant converter having high voltage gain and low input current ripple. Converter switches are controlled through hysteresis controller and ZCS resonant topologies. Solar PV power fluctuates according to irradiation level of sunlight and hence tracking of maximum power at all time is mandatory. SPWM control with third harmonic injection is used to trigger the IGBT’s in the inverter. The development is oriented to achieve a more efficient, reliable, maintenance free and cheaper solution than the standard ones, that uses DC motors or low voltage synchronous motors. The proposed method is verified with MATLAB/SIMULINK and the system simulation confirms the performance of the proposed system.
An Approach to Voltage Quality Enhancement by Introduction of CWVM for Distribution System
Authors: Shrivastav Alok Kumar , Sadhu Pradip Kumar , Ganguly Ankur , Dhara Saumen
Published: February 2017

This paper presented with problems related with voltage flicker in power system networks. Several international standard issued to control the voltage flicker are briefly described and some important methods to analyse electrical circuits with sinusoidal and non-sinusoidal waveforms are introduced and evaluated. One of these methods – Cockcroft Walton Voltage Multiplier (CWVM) has been used to increase the voltage of a filter, which is also described in this paper as a practical application. The filter can compensate for harmonic currents, power factor, and unbalance voltage. The simulation results using Multisim are presented, showing that good dynamic and steady-state response can be achieved with this approach.
A Discrete PLL based Load Frequency Control of FLC-based PV-wind Hybrid Power System with Real Time Data
Authors: Kumar A. V. Pavan , Parimi Alivelu M. , Rao K. Uma
Published: February 2017

The sun and wind based generation are considered to be alternate source of green power generation which can mitigate the power demand issues. As solar and wind power advancements are entrenched and the infiltration of these Renewable Energy Sources (RES) into to network is expanding dynamically, testing errand is to keep up the voltage and frequency of the power generated from RES consistent as they specifically relies upon environmental conditions. So, as to outline a legitimate control and to harness power from RES the learning of natural conditions for a specific area is fundamental. With this fundamental information of the environmental conditions, a suitable Photovoltaic and Wind power generations is selected to generate clean and green electricity. Fuzzy Logic Controller (FLC) based Maximum Power Point Tracking (MPPT) controlled boost converter are utilized for viable operation and to keep DC voltage steady at desired level. The control scheme of the inverter is intended to keep the load voltage and frequency of the AC supply at constant level regardless of progress in natural conditions and burden. A Simulink model of the proposed Hybrid system with the MPPT controlled Boost converters and Voltage regulated Inverter for stand-alone application is developed in MATLAB R2015a, Version 8.5.0. The ongoing information of Wind Speed and Solar Irradiation levels are recorded at BITS-Pilani, Hyderabad Campus utilizing climate observing framework introduced at the area the performance of the voltage regulated inverter under constant and varying linear AC load with the real time data of the solar irradiation and wind speed as input is analyzed. The investigation shows that the magnitude of load voltage and frequency of the load voltage is maintained at desired level by the proposed inverter control logic.
Performance and Energy Saving Analysis of Grid Connected Photovoltaic in West Sumatera
Authors: Ghazali Syafii , Nazir Refdinal
Published: February 2017

The paper presents performance and energy saving analysis of 1.25 kWp grid connected Photovoltaic system under difference weather condition in West Sumatera.  The measured data were performed during weather data that often occur in West Sumatra i.e. sunny, overcast, raining and cloudy. The synchronizing process successfully done even bad weather conditions when sunlight was low automatically. Photovoltaic in average start producing power from 7:00 AM to 6:00 PM for normal or clear sky, however under overcast, raining and cloudy weather, the PV power decreased and disconnected earlier before sunset. During intermittent raining, overcast and cloud covered the PV power output show an irregular profile. The PV energy saving performed for three residential connection cases: 1300 VA, 900 VA with subsidized and 900 VA without subsidized. The solar PV installation have more benefits and energy saving for 1300 VA, 900 VA without subsidized with payback period around 8.5 years. However, the 900 VA with subsidized take longer 20.8 years, but still in PV lifespan 25 years. In the future, household subsidies may be reduced or eliminated, the solar energy will be viable alternative of energy resources when it can produce electricity at a cost equivalent to utility grid PLN rate. 
Modelling of Virtual Synchronous Converter for Grid-inverter Synchronization in Microgrids Applications
Authors: Amin Md. Ruhul , Zulkifli Shamsul Aizam
Published: February 2017

In this paper, virtual synchronous converter (VSCon) is modelled which behaves as synchronous generator including its all real-time characteristics in operating inverter. This VSCon is used to synchronize grid and inverter while integrating distributed generated power to microgrids. The frequency and voltage synchronization can be controlled by using synchronous generator mathematical model is installed into the inverter. The whole unit of VSCon operated is simulated in Matlab/Simulink for observing all consequences for synchronizing voltage, frequency and phase-angle. It is verified that the next generation energy resources can be integrated into microgrid making synchronization grid-inverter using VSCon. The simulation results are given to verify the concept of modelling VSCon functioning inverter as a synchronous generator. 
Modified Distribution Transformer for Enhancing Power Quality in Distribution Systems
Authors: P.K. Preetha , Chandramohanan Nair P.S.
Published: February 2017

The percentage of non-linear loads in the power distribution sector is increasing day by day. Harmonics injected by these non-linear loads circulate in the delta windings of the conventional distribution transformer thereby increasing the temperature and losses. This reduces the efficiency and life of the transformers. In a modified distribution transformer configuration proposed recently, called star-star-delta_utilized configuration (YYD_utilized), the harmonics circulating in the delta winding was utilized and the drainage power thus recovered was used to power auxiliary loads. This paper presents the experimental studies conducted on YYD_utilized distribution transformer. When compared to conventional star-star, delta-star and star-star-delta transformers, the new configuration of YYD_utilized transformer has shown considerable improvement in transformer efficiency.  The results obtained show that when the power from the circulating harmonics is recovered and utilized, it not only improves transformer efficiency but also improves the power factor and reduces the harmonic distortions at the primary side of the transformer. The results obtained also suggest the existence of maximum power point or an optimum loading for the recovered harmonic power.
Prognostic Value of Right Ventricular Ejection Fraction Assessed by Transthoracic 3D Echocardiography
Authors: Nagata Yasufumi , Wu Victor Chien-Chia , Kado Yuichiro , Otani Kyoko , Lin Fen-Chiung , Otsuji Yutaka , Negishi Kazuaki , Takeuchi Masaaki
Published: February 2017

Background—

Cardiac magnetic resonance is the gold standard for the evaluation of right ventricular (RV) volumes, but it is impractical to perform in every patient. Although reference values of RV volumes and RV ejection fraction by 3D transthoracic echocardiography (3DTTE) have been established, their prognostic values have not been elucidated yet. We hypothesized that RV ejection fraction measured by 3DTTE (3DRVEF) predicts future cardiovascular events.

Methods and Results—

In protocol 1, we determined the accuracy of RV volumes and RV ejection fraction measurements by 3DTTE against cardiac magnetic resonance in 60 subjects. In protocol 2, 3DRVEF was measured in 446 patients with various cardiovascular diseases. Study subjects were followed up to record cardiac death and major adverse cardiovascular events. In protocol 1, 3DTTE-determined RV end-diastolic volume, end-systolic volume, and RV ejection fraction had good correlations to those by cardiac magnetic resonance (
r
=0.74–0.90). In protocol 2, 38 cardiac deaths and 88 major adverse cardiovascular events occurred during a median follow-up of 4.1 years. Univariable Cox proportional analysis revealed that 3DRVEF was associated with both cardiac death (
P
<0.0001) and major adverse cardiovascular event (
P
<0.0001). 3DRVEF remained as an independent predictor for cardiac death (
P
<0.0001) and major adverse cardiovascular event (
P
<0.0001) even in a stepwise multivariable Cox proportional hazard analysis. Classification and regression-tree analysis demonstrated that 3DRVEF played an important role for risk stratification.

Conclusions—

3DTTE-determined RV ejection fraction was independently associated with cardiac outcomes in patients with diverse backgrounds. 3DRVEF offered incremental value over clinical risk factors and the other echocardiographic parameters including left ventricular systolic and diastolic function for predicting future adverse outcome.
Intravenous Thrombolysis in Unknown-Onset Stroke
Authors: Dorado Laura , Ahmed Niaz , Thomalla Götz , Lozano Manuel , Malojcic Branko , Wani Mushtaq , Millán Mònica , Tomek Ales , Dávalos Antoni
Published: February 2017

Background and Purpose—

Stroke patients with unknown onset (UKO) are excluded from thrombolytic therapy. We aim to study the safety and efficacy of intravenous alteplase in ischemic stroke patients with UKO of symptoms compared with those treated within 4.5 hours in a large cohort.

Methods—

Data were analyzed from 47 237 patients with acute ischemic stroke receiving intravenous tissue-type plasminogen activator in hospitals participating in the Safe Implementation of Treatment in Stroke-International Stroke Thrombolysis Registry between 2010 and 2014. Two groups were defined: (1) patients with UKO (n=502) and (2) patients treated within 4.5 hours of stroke onset (n=44 875). Outcome measures were symptomatic intracerebral hemorrhage per Safe Implementation of Treatment in Stroke on the 22 to 36 hours post-treatment neuroimaging and mortality and functional outcome assessed by the modified Rankin Scale at 3 months.

Results—

Patients in UKO group were significantly older, had more severe stroke at baseline, and longer door-to-needle times than patients in the ≤4.5 hours group. Logistic regression showed similar risk of symptomatic intracerebral hemorrhage (adjusted odds ratio, 1.09; 95% confidence interval, 0.44–2.67) and no significant differences in functional independency (modified Rankin Scale score of 0–2; adjusted odds ratio, 0.79; 95% confidence interval, 0.56–1.10), but higher mortality (adjusted odds ratio, 1.58; 95% confidence interval, 1.04–2.41) in the UKO group compared with the ≤4.5 hours group. Patients treated within 4.5 hours showed reduced disability over the entire range of modified Rankin Scale compared with the UKO group (common adjusted odds ratio, 1.29; 95% confidence interval, 1.01–1.65).

Conclusions—

Our data suggest no excess risk of symptomatic intracerebral hemorrhage but increased mortality and reduced favorable outcome in patients with UKO stroke compared with patients treated within the approved time window.
Beyond the Myth of a Non-relationship: International Law and World War i
Authors: Diggelmann Oliver
Published: February 2017

This article examines the relationship between international law and World War i from a basic perspective. The first question is whether, and to what degree, international law can or should be regarded as a contributing cause for the outbreak of World War i. Three aspects of international law prior to World War i are discussed: the silent ‘alliance’ between the ius ad bellum and social Darwinism, the lack of individual accountability of the members of the political and military elites under international law, and the role of the law of reprisal as a ‘fire accelerant’ of conflicts. The second focal point lies on central questions of international law during the war. Again, three aspects are addressed: the relationship between international law and new weapons as well as new methods of warfare, legal issues related to long-term occupations and the role of international law with respect to prisoners of war.
Group Politics in the Debates on Gender Equality and Sexual Orientation Discrimination at the United Nations
Authors: Smith Karen E.
Published: February 2017

This article assesses the impact of ‘group politics’ in the particularly contentious debates of the United Nations (un) Human Rights Council and the un General Assembly regarding gender equality and discrimination on the basis of sexual orientation. The article identifies those groups that have been most active in the debates, and then analyses how and why they have shaped debates and norms in this area, how they interact with each other, and whether groups help to facilitate consensus or foster polarization in debates. The article examines the extent to which these groups are cohesive, and identifies the norms that each group puts forward in debates (through statements and resolutions). It then assesses and explains their impact on outcomes, the creation of shared norms and the potential for collective action. It further explores the implications of increasing cross-regional group activity in the Human Rights Council.
Martin Schreiner and Jewish Theology: An Introduction
Authors: Turán Tamás
Published: February 2017

Martin Schreiner (1863–1926), a rabbi in Hungary and later a professor at the liberal rabbinical seminary in Berlin, was a disciple of David Kaufmann and Ignaz Goldziher, and a prominent scholar of Medieval Islamic and Jewish thought. The present article deals with his little-known contributions to religious thought in the late nineteenth century, utilizing also his unpublished work on Jewish religious philosophy and his correspondence with Goldziher. Schreiner’s unique quest for a combination of liberal, academic Jewish theological inquiry with conservative loyalty to religious law—a precarious stance, a neo-Maimonidean attitude of sorts—confronted and challenged all the religious platforms which evolved in modern Judaism.
Verbascum ifranensis (Scrophulariaceae), a new endemic species from Morocco
Authors: KHAMAR HAMID , CIVEYREL LAURE , PELISSIER CELINE , BADR DIANA , EL OUALIDI JALAL , TOUHAMI-OUAZZANI AMINA
Published: February 2017

Verbascum ifranensis Khamar H. & al. is described as a new endemic species from the Middle Atlas Mountains in Morocco, based on morphology of vegetative and reproductive organs. We provide notes on its delimitation from closely related species, especially V. dentifolium Delile and V. lychnitis L. Comparison of ITS sequences and a distance matrix analysis is provided for V. ifranensis and the two closely related species to add molecular evidence to the morphological findings. In addition the geographical distribution and the conservation status are assessed.
Modeling Evapotranspiration over China’s Landmass from 1979 to 2012 Using Multiple Land Surface Models: Evaluations and Analyses
Authors: Sun Shaobo , Chen Baozhang , Shao Quanqin , Chen Jing , Liu Jiyuan , Zhang Xue-jun , Zhang Huifang , Lin Xiaofeng
Published: February 2017

Land surface models (LSMs) are useful tools to estimate land evapotranspiration at a grid scale and for long-term applications. Here, the Community Land Model, version 4.0 (CLM4.0); Dynamic Land Model (DLM); and Variable Infiltration Capacity model (VIC) were driven with observation-based forcing datasets, and a multiple-LSM ensemble-averaged evapotranspiration (ET) product (LSMs-ET) was developed and its spatial–temporal variations were analyzed for the China landmass over the period 1979–2012. Evaluations against measurements from nine flux towers at site scale and surface water budget–based ET at regional scale showed that the LSMs-ET had good performance in most areas of China’s landmass. The intercomparisons between the ET estimates and the independent ET products from remote sensing and upscaling methods suggested that there were fairly consistent patterns between each dataset. The LSMs-ET produced a mean annual ET of 351.24 ± 10.7 mm yr−1 over 1979–2012, and its spatial–temporal variation analyses showed that (i) there was an overall significant ET increasing trend, with a value of 0.72 mm yr−1 (p < 0.01), and (ii) 36.01% of Chinese land had significant increasing trends, ranging from 1 to 9 mm yr−1, while only 6.41% of the area showed significant decreasing trends, ranging from −6.28 to −0.08 mm yr−1. Analyses of ET variations in each climate region clearly showed that the Tibetan Plateau areas were the main contributors to the overall increasing ET trends of China.
Self-directed Learning in Otolaryngology Residents’ Preparation for Surgical Cases
Authors: Jabbour Jad , Bakeman Anna , Robey Thomas , Jabbour Noel
Published: February 2017

Objectives:

To characterize the nature of surgical preparation among otolaryngology residents nationwide, determine the self-rated effectiveness and efficiency of case preparation practices, and identify potential means for educational improvement.

Methods:

A survey examining the study objectives was developed and distributed to otolaryngology residents nationwide. Survey response data were submitted to descriptive analysis and comparative analyses between junior and senior residents. Literature regarding case preparation among otolaryngology residents was reviewed.

Results:

Among 108 resident respondents, the most commonly used resources included textbooks (86.1%), surgical education websites (74.1%), and surgical atlases (66.7%). Time was the primary limitation (cited by 84.3%) and convenience the predominant factor influencing resource selection (92.5%). On a 5-point Likert scale, mean scores regarding effectiveness and efficiency of case preparation were 3.53 ± 0.68 and 3.19 ± 0.88, respectively. Senior residents compared to junior residents were more likely to rate their preparation as effective (3.75 ± 0.54 vs 3.40 ± 0.72, P = .008) and efficient (3.45 ± 0.85 vs 3.03 ± 0.86, P = .02).

Conclusion:

Otolaryngology residents do not consistently rate their case preparation as effective or efficient. While there appears to be progress in self-directed learning throughout residency, room for improvement remains, with potential avenues for such improvement explored here.