bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling and evaluating piston slap-induced cavitation of cylinder liners in heavy-duty diesel engines.
Authors: Liu Dong , Sun Nannan , Zhu Guixiang , Cao Hengchao , Wang Tie , Li Guoxing , Gu Fengshou
Published: July 2023

Cavitation erosion of cylinder liner seriously affects the operational reliability and service life of heavy-duty diesel engines. The accuracy of the modeling-based cavitation risk evaluation is limited by the unclear correspondence between cylinder liner vibration and coolant cavitation. This report is intended to investigate the correspondence between cylinder liner vibration and coolant pressure by combining vibration cavitation test, pressure gradient calculation, and visualization observation. The cavitation risk of the cylinder liner under piston slap is also quantitatively analyzed based on the nonlinear structural dynamics model. The results show that the occurrence of cavitation will cause a nonlinear relationship between the cylinder liner acceleration and the coolant pressure. The difference in cavitation risk for each cylinder is related to the structural modal characteristics of the crankcase. In addition, the effect of piston-liner clearance and piston pin offset on the cavitation risk is investigated based on the dynamics model.
Türkiye’de İş Biçimlendirme (Job Crafting) Çalışmaları: Lisansüstü Tezlere Yönelik Bir İnceleme
Authors: GERÇEK Merve , ZİĞALOĞLU Dilek
Published: July 2023

Çalışanların işlerinin bazı özelliklerini değiştirmelerine yönelik proaktif davranışlar olarak bilinen iş biçimlendirme (job crafting), çalışanların işe adanmışlık, örgüte bağlılık ve performans düzeylerini olumlu yönde etkileme potansiyeline sahiptir. Bu çalışmanın amacı, Türkiye’de iş biçimlendirme konusundaki akademik çalışmaların genel durumunu ortaya koyarak, incelenen olgu ile ilgili eğilimleri belirlemek ve elde edilen bulgular ışığında gelecek araştırmalara yol gösterebilmektir. Bu amaçla, Yükseköğretim Kurulu Başkanlığı Ulusal Tez Merkezi’nden erişilen 41 lisansüstü tez, doküman analizi yöntemiyle incelenmiş, bu tezlerin tür, üniversite, anabilim dalı, yayın yılı, yayın dili, yöntem gibi niteliklerine göre dağılımları belirlenmiştir. Bulgulara göre, iş biçimlendirme konusundaki tezlerin sayısının son üç yılda arttığı, çoğunda çalışanları kapsayan örneklem kullanıldığı, iş biçimlendirmeyle birlikte en sık çalışılan değişkenlerin iş karakteristikleri, örgütsel destek, işe adanmışlık ve performans olduğu belirlenmiştir. Özgün karşılığı “Job Crafting” olan bu kavramın, farklı Türkçe karşılıklarının kullanıldığı görülmüştür. Bu çalışmanın, Türkiye’de iş biçimlendirme çalışmalarındaki gelişmeleri ortaya koyarak araştırmacılara yeni bakış açıları kazandırması beklenmektedir.
ANALYSIS OF THE DEVELOPMENT OF THE INSURANCE INDUSTRY IN AZERBAIJAN COMMONWEALTH
Authors: AKBULAEV Nurkhodzha , SALİHOVA Sudabe
Published: July 2023

Today insurance is connected with all types of trade, industry and an important part of the social structure. Insurance, combined with security qualifications, is also an element of trust. In addition, the Creator of funds for economic activities, capital accumulation has become a criterion for ensuring and improving well-being. For this reason, insurance is one of the most important activities faced by developed countries. In other words, there is a strong correlation between insurance activities and economic activities. Social benefits, as well as economic benefits and pension funds, are important in this industry. the share of the insurance sector in GDP is higher than in the developed countries of other countries. The level of development of the country is the greatness of the insurance industry. In this article theoretical bases of insurance, types of insurance in the Azerbaijan Republic are examined, the comparative Analysis of the insurance market of Azerbaijan is made. The article reveals that the insurance market of Azerbaijan is located in the state of development. As in present law, normative legal base regulating this sphere of activity. For this reason, there is a need to analyze the insurance industry as a separate industry.
Сравнительная оценка влияния Содерм®-Форте, Цитофлавина® и их сочетания на микроциркуляцию в слизистой десны крыс
Authors: Галенко-Ярошевский Павел А. , Раваева Марина Ю. , Чуян Елена Н. , Задорожний Марк А. , Попков Виктор Л. , Зеленская Анаит В. , Хейгетян Артур В. , Алуханян Лусине О. , Стаценко Елизавета В. , Матеренчук Мария Ю. , Лебедева Светлана А.
Published: July 2023

Введение. Изменения в системе микроциркуляции (МЦ) отражают нарушения физиологических процессов в организме и служат диагностическим и прогностическим фактором многих патологических состояний, в том числе, воспалительных поражений тканей пародонта. Поскольку в патогенезе микроциркуляторных расстройств важную роль играют процессы свободно-радикального окисления, препараты, обладающие антиоксидантным действием, представляют определенный интерес с точки зрения фармакологической коррекции нарушений кровотока в пародонтальном комплексе. Представляло интерес провести сравнительную оценку влияния Содерм®-Форте, Цитофлавина® и их сочетания на МЦ в слизистой оболочке десны крыс. Цель исследования – выявить наличие способности Содерм®-Форте, Цитофлавина® и их сочетания повышать микроциркуляцию в слизистой оболочке десны крыс.
 Материалы и методы. Исследование МЦ в слизистой десны крыс проводили методом лазерной допплеровской флоуметрии. Было сформировано 4 группы крыс по 10 особей в каждой: 1 группа контрольная; 2-4 – подопытные, животным которых наносили гель Содерм®-Форте на слизистую десны нижних резцов, инъецировали Цитофлавин® (100 мг/кг внутрибрюшинно – в/бр) и наносили гель Содерм®-Форте на слизистую десны на фоне в/бр введения Цитофлавина® соответственно. Показатели кровотока регистрировали через 30 и 60 мин.
Результаты и их обсуждение. Содерм®-Форте увеличивал МЦ слизистой десны за счет повышения базального уровня NO, активности прекапиллярных сфинктеров и метартериол, снижения активности адренергических вазомоторов. Цитофлавин® повышал активность прекапиллярных сфинктеров и метартериол, внесосудистых компонентов МЦ, не изменял перфузию слизистой десны. Сочетание Содерм®-Форте и Цитофлавина® повышало МЦ в меньшей степени, чем Содерм®-Форте, но более выраженно, чем Цитофлавин®.
Заключение. По способности увеличивать кровоток в слизистой десны крыс исследованные вещества и их сочетание можно расположить в следующий ряд: Содерм®-Форте > Содерм®-Форте + Цитофлавин® > Цитофлавин®.
Графическая аннотация
Struktura władzy i podziały administracyjne obwodu kaliningradzkiego
Authors: Palmowski Tadeusz
Published: July 2023

Obwód kaliningradzki stanowi jeden z 89 podmiotów Federacji Rosyjskiej. Nowy samorząd, wykorzystujący standardy europejskie, wprowadziła tu ustawa federalna przyjęta w 1995 r. Najwyższym organem ustawodawczym władzy państwowej obwodu jest Kaliningradzka Duma Obwodowa. Funkcjonuje ona na równi z gubernatorem. Podział administracyjny obwodu od 2010 r. składa się z trzech poziomów. Pierwszym jest cały obwód. Drugi poziom stanowi sześć miast o znaczeniu obwodowym i jedno osiedle miejskie. W skład poziomu trzeciego przyporządkowano 66 gmin, z tego 19 miejskich oraz 47 gmin wiejskich.
Method and the device of actualization of controlling effect loading of knot of the electric power system
Authors: Shuvalova Alena A. , Polishchuk Vladimir I.
Published: July 2023

Subject of research: is the technique of identification СCL in electric power system knots.

Purpose of research: consists in working out of a technique of monitoring of changes КREL in electric power system knot.

Methods of research: imitating modelling of electric modes, digital processing of signals, method of natural experiment.

Main results of research: the technique of monitoring КREL of knot of an electric power system of digital processing of the information based on a method has been as a result developed, having author's specific features, also has criteria of suitability of data and the device realising a technique is developed. Experimental approbation of work of the device analyzing data from means of a telemetering, an operatively-measuring complex or automated data management system is spent. Device check has shown, that on an indication range 0,75 1,2Uном the error of identification КREL has made 0,2 % that speaks about high reliability of an offered technique of actualisation КREL.
Reflecting on the use of freedom of information requests in mental health research
Authors: Archard Philip John , Tangen James , Giles Emma , Lucas Steven , Moore Isobel , O'Reilly Michelle , Murphy David
Published: July 2023

Freedom of information (FoI) legislation has been represented as a valuable but underused means of generating otherwise unavailable data from public authorities in health and social care research. This article complements extant literature on the use of FoI requests for research intended to inform health and social care policy and improve the quality of practice. Reflections are provided on challenges and ethical considerations, drawing on relevant literature and the authors’ experience undertaking studies addressing different topics in mental health and child welfare using FoI requests as the primary source of data collection. The recommendations are practically orientated and aimed primarily at social work and health and social care researchers who may have limited knowledge of how FoI requests might be utilised in their work but be curious about this method’s application.
Genius of poetic expression. Part one (Based on the publicistic article by S.N. Sergeev-Tsensky “Gogol as an artist of the word”)
Authors: Khvorova Liudmila E.
Published: July 2023

In the aspect of the “scientific-research dialogue” of the author of this study with the writer of the twentieth century Sergei Nikolaevich Sergeev-Tsensky, his publicistic miniatures “Gogol as an artist of the word” (1952), “Talent and genius” (1957), included in the collection “Work hard and joyfully”. It is emphasized that the writer’s work the of the twentieth century Sergeev-Tsensky was written as a pedagogical parting word to future generations and as a call to cherish and study their native Russian language, to cherish the Russian word on the material of the “genius of artistic expression” Nikolai Vasilyevich Gogol. The stylistic and poetic findings of the writer in various stories, in the poem “Dead Souls” and in the dramatic work – the comedy “The Government Inspector” are considered. The ways of creating a literary portrait and landscape, the language system means in depicting the psychological details of the portrait and landscape characteristics of comic heroes (on the example of the portrait of Sobakevich), as well as the speech characteristics of the “The Government Inspector” are investigated. Attention is drawn to Gogol’s techniques of “style play” and some deliberate violations of lexical norms in the construction of portrait characteristics in order to emphasize very significant psychological details. As an addition to Sergeev-Tsensky’s reasoning, the specifics of Gogol’s descriptiveness in the real and the fantastic synthesis are specified on the example of significant details, for example, the story “Viy” from the “Mirgorod” cycle. The fear of the author of “Mirgorod” and “Taras Bulba” of confusion in the minds of the characters of Divine and demonic forces is emphasized.
Exploring the Prospects of Macadamia Nutshells for Bio-Synthetic Polymer Composites: A Comprehensive Review
Authors: Khan Md Sefat , Islam Md Mainul , Epaarachchi Jayantha , Shibata Shinichi
Published: July 2023

The global production of macadamia nuts has witnessed a significant increase, resulting in the accumulation of large quantities of discarded nutshells. These nutshells possess remarkable hardness and toughness, comparable to aluminum. Incorporating natural fillers to enhance the properties of composite materials for various applications, including light duty, structural, and semi-structural purposes, is a common practice. Given their inherent hardness and toughness, macadamia nutshells present an intriguing choice as fillers, provided that the manufacturing conditions are economically viable. With the urgent need to shift towards natural fillers and reduce reliance on synthetics, exploring macadamia nutshells as components of natural fiber composites becomes imperative. This review aims to comprehensively examine the existing body of knowledge on macadamia nutshells and their bio-synthetic polymer composites, highlighting key research findings, achievements, and identifying knowledge gaps. Furthermore, the article will outline prospective areas of focus for future research endeavors in this domain, aligning with the universal goal of minimizing synthetic materials.
Exploring the State of Machine Learning and Deep Learning in Medicine: A Survey of Italian Research Community
Authors: Bottrighi Alessio , Pennisi Marzio
Published: July 2023

Artificial Intelligence (AI) is becoming increasingly important, especially in the medical field. While AI has been used in medicine for some time, its growth in the last decade has been remarkable. Specifically, Machine Learning (ML) and Deep Learning (DL) techniques in medicine have been increasingly adopted thanks to the growing abundance of health-related data, improved suitability of such techniques for managing large data-sets, and more computational power. The Italian scientific community has been instrumental in advancing this research area. This article aims to conduct a comprehensive investigation of the ML and DL methodologies and applications used in medicine by the Italian research community in the last five years.
Blood Plasma Small Non-Coding RNAs as Diagnostic Molecules of Progesterone Receptor-Negative Phenotype of Serous Ovarian Tumors
Authors: Timofeeva Angelika V. , Fedorov Ivan S. , Asaturova Alexandra V. , Sannikova Maya V. , Tregubova Anna V. , Mayboroda Oleg A. , Khabas Grigory N. , Frankevich Vladimir E. , Sukhikh Gennady T.
Published: July 2023

Progesterone receptor (PGR) expression level determines biological characteristics of the serous ovarian carcinoma, and low PGR expression appears to be associated with chemoresistance and worse outcome. In this study, we aimed to find relationships between tumor progesterone receptor level and RNA-profile (miRNAs, piwiRNAs, and mRNAs), determining its biological characteristics and behavior. For this purpose, we applied next generation sequencing of small noncoding RNAs, quantitative RT-PCR, and immunohistochemistry to analyze FFPE and frozen tumor samples as well as blood plasma from patients with benign cystadenoma (BSC), serous borderline tumour (SBT), low-grade and high-grade serous ovarian carcinoma (LGSOC and HGSOC, respectively). We found significant upregulation of MMP7 and MUC16 and downregulation of PGR in LGSOC and HGSOC in comparison with BSC. The tissue content of miR-199a-5p, miR-214-3p, miR-424-3p, miR-424-5p, miR-125b-5p significantly inversely correlated with the expression level of MUC16 and blood serum CA125 concentration, and significantly directly correlated with the PGR expression level in tumor tissue. On the contrary, the tissue content of miR-16-5p, miR-17-5p, miR-20a-5p, miR-93-5p, responsible for epithelial-mesenchymal transition (EMT) of the cell, significantly directly correlated with the blood serum CA125 concentration and significantly inversely correlated with the PGR expression level in the tumor tissue. Levels of the EMT-associated miRNAs significantly directly correlated with the content of hsa_piR_022437, hsa_piR_009295, hsa_piR_020813, hsa_piR_004307, hsa_piR_019914 in tumor tissues. Among them, expression level of hsa_piR_004307 significantly inversly correlated with the PGR expression level in the tumor. Two optimal logistic regression models were developed based on the quantitation of hsa_piR_020813, miR-16-5p, hsa_piR_022437 or hsa_piR_004307, hsa_piR_019914, miR-93-5p in the tumor tissue, both of which significantly diagnose PGR-negative tumor phenotype with 93% sensitivity. According to FunRich3.1.3 functional enrichment analysis tool, 72 gene-targets of miRNA and piRNA identified here as markers of PGR-negative ovarian tumor phenotype were proven to be mutated in different cancers such as ovarian, breast, colorectal, liver, stomach, lung, endometrial, thyroid cancer. Among them, the blood plasma levels of miR-16-5p and hsa_piR_022437 can be used to diagnose PGR-negative tumor phenotype with 86% sensitivity before surgery and chemotherapy to choose the treatment strategy for this most aggressive type of ovarian cancer (for instance, neoadjuvant chemotherapy followed by cytoreduction in combination with hyperthermic intraperitoneal chemotherapy) to increase the effectiveness of treatment and longevity of the patient.
Association between SARC F Questionnaire Score and Functional Performance in Patients with Hip Osteoarthritis
Authors: Zasadzka Ewa , Kasior Iwona , Hojan Katarzyna
Published: July 2023

Background and Objectives:: Hip osteoarthritis is the main cause physical disability, also has a serious impact on the efficiency and independence of older people. The aim of the study was to analyze the relationship between hip osteoarthritis and the risk of sarcopenia. Our main hypothesis was whether the risk of sarcopenia, as measured by the SARC F questionnaire , is related to the physical fitness of older people with hip osteoarthritis. Materials and Methods: The study was conducted with the participation of 177 people of aged 65 or more, diagnosed hip osteoarthritis. The subjects were assessed using the SARC F questionnaire, the Short Physical Performance Battery (SPPB) and Timed Up and Go (TUG) test. The subjects were divided into two groups depending on the result they obtained in the SARC F questionnaire (group 1- SARC F <4, group 2 - SARC F ≥ 4). Results: There was a significant correlation between the results in the SARC F and the results of the TUG (p<0.001) and the SPPB test, both the SPPB total score (p<0.001)and its elements: SBBP chair stand test (p<0.001), SPPB balance test (p<0.001), SPPB gait speed test (p<0.001). Logistic regression of the SPPB and TUG predictors showed that in SARC F more than 4 predicted worse SPPB and TUG outcomes. In the SARC group, F above 4 increases the odds of poorer scores in SPPB OR=1.097; CI 95% 1.053-1.146 and TUG, OR=1.096; CI 95% 1.104-1.266. Conclusion: The study showed that the results obtained in the SARC F questionnaire correlate with the possibilities of physical functioning in patients with hip osteoarthritis SARC F is an inexpensive method that can be used to assess the risk of sarcopenia. Healthcare professionals, especially in primary care, should consider assessing the risk of sarcopenia especially in people with hip osteoarthritis.
Land use change scenarios building combining agricultural development policies, landscape planning approaches and ecosystem services assessment. The Campania Region (Italy) case-study
Authors: Cervelli Elena , Recchi Pier Francesco , Perta Ester Scotto di , Pindozzi And Stefania
Published: July 2023

In the last two centuries, land use change (LUC) has been the most important direct changes driver for terrestrial ecosystems. To contrast the consequent ecosystems degradation, forward-looking spatial policies and target landscape and land-use planning processes, promoting a sustainable land use change, are needed. The present paper proposes a framework of action including different landscape planning and ecological approaches: from the spatial modelling to recognize the LUC and build different scenarios, to the ecosystem services (ESs) assessment to evaluate the possible environmental impacts. Three different scenarios were built: Trend, No-Tillage and Energy crops. The Sediment Delivery Ratio and Carbon Storage and Sequestration ESs were assessed and compared for each scenario. The aim of the paper is to support decision-makers and local communities into the landscape planning process. Results show that a regional development in line with past trend could lead to further land degradation. Instead, the two scenarios proposed in compliance with EU policies, could bring benefits only if related to moderate LUCs and respecting the naturally grass-vegetated land. From the local to global scale, a guided and shared LUC management allows implementing sustainable development, basing on a deep knowledge of physical-environmental but also social and economic issues.
The usefulness of the ratio of antigen-autoantibody immune complexes to their free antigen in the diagnosis of non-small cell lung cancer
Authors: Hong Young Jun , Kim Heyjin , Lee Jin Kyung , Oh Ae-Chin , Kim Hye-Ryoun
Published: July 2023

Autoantibodies against specific lung cancer-associated antigens have been suggested for lung cancer diagnosis. This study aimed to evaluate the diagnostic performance of anti-gen-autoantibody immune complex (AIC) against its free antigens for CYFRA21-1, ProGRP, NGAL, and NSE in non-small cell lung cancer (NSCLC). In total, 85 patients with NSCLC and 120 healthy controls (HCs) were examined using a 9G DNA chip method. The ratios of AICs to their antigens and combinations of ratios consisting of two to four markers were calculated. The levels of AICs for CYFRA21-1, ProGRP, NGAL, and NSE were higher than their free antigens in all participants. The levels of each free antigen distinguished patients with NSCLC from HCs. The ratios of AIC to its antigen and seven combinations consisting of two to four ratios were significantly higher in patients with NSCLC than those in HCs. Excellent diagnostic performance was observed for all combination ratios (C4-1), with 85.9% sensitivity and 86.7% specificity at cutoff 3.51. Higher sensitivity was observed in the very early stages (0–I) and adenocarcinoma than in stages II–IV and other pathological types. The combination of all ratios of AICs and their antigens for all four markers is useful in the diagnosis of NSCLC.
Prognostic value of platelet–lymphocyte ratio, neutrophil–lymphocyte ratio and monocyte–lymphocyte ratio in HNSCC - a retrospective single center study
Authors: Mirestean Camil Ciprian , STAN MIHAI COSMIN , Iancu Roxana Irina , Iancu Dragoș Petru Teodor , BADULESCU FLORINEL
Published: July 2023

Introduction: The identification of some prognostic markers in head and neck cancers (HNC) is necessary for the stratification of the therapeutic approach with benefits in increasing treatment response rates and limiting the toxic side effects of treatments. Neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and pallets-to-lymphocyte ratio (PLR) are currently validated as cheap and accessible biomarkers in different types of solid tumors.
The purpose of the study was to evaluate the possible biomarker value of NLR, PLR and MLR recorded pre-treatment (radiotherapy/chemotherapy) for prognostic purposes in HNC.
Materials and methods: The study included 190 patients with HNC included in the oncology record in the oncology outpatient clinic of the Craiova County Emergency Hospital starting from January 2002 and deceased until December 2022. Among them, 40 patients treated multimodally in the Clinic were included in the study of Oncology of the Craiova County Emergency Hospital for which the pre-treatment value (chemotherapy/radiotherapy) of NLR, PLR and MLR could be calculated. Overall survival (OS) values were correlated with NLR, PLR and MLR.
Results: Median values for NLR, PLR and MLR were 6.15 (1.24-69), 200.79 (61.3- 1775.0) and 0.53 (0.12-5.5) respectively. In the study, the mean values for NLR, PLR and MLR of 2.88, 142.97 and 0.36 respectively were obtained. Median OS in the study group was 11 months (1-120). Although a negative Pearson`s correlation, the relationship between your variables was only weak, values R =.07, p=.67; R=.02, p=.31 and R=07, p=.62 being related with NLR, PLR and MLR respectively correlation with overall survival (OS). The median values of NLR, PLR and MLR were calculated (1.53, 90.32 and 0.18 respectively) for HNC cases with pre-treatment values of NLR <2 and for HNC cases with NLR values ≥6 (23.5, 232.78 and 0.79 respectively). Median OS for cases with NLR<2 and NLR≥6 were 17.4 and 13 months, respectively.
Conclusions: The negative correlations of NLR, PLR and MLR with OS reported in the study are in accordance with the data reported in the literature for locally advanced recurrent and metastatic HNSCC cases. The comparative analysis of the data in the group with NLR<2 and NLR≥6 highlights an advantage of 4.4 months in median OS in favor of the group with low values of NLR. Being cheap and accessible, these markers could change the therapeutic approach even in centers with limited resources. The role of borderline NLR values as a prognostic factor in HNSCC must also be defined. PLR and MLR are less evaluated as biomarkers but the study demonstrates their potential to be used as prognostic biomarkers, it remains to be clarified if their inclusion in multivariable models along with NLR would bring a benefit
Revolutionizing Digital Healthcare: Unlocking the Power of Blockchain with an Optimized Fuzzy Logic Approach to Authentication and Key Agreement
Authors: Ali Aitizaz , Tin Ting , Al-rimy Bander , Abdalla Elfadil Eisa Taiseer , Gan Hong-Seng , Chaw Jun
Published: July 2023

Digital healthcare systems play a pivotal role in providing efficient and accessible healthcare services. However, ensuring secure authentication and key agreement mechanisms is essential to protect sensitive patient data and maintain the integrity of the system. The existing methods face limitations in terms of vulnerability to cyber attacks, scalability, and resource utilization. Furthermore, the integration of blockchain technology introduces new complexities that need to be addressed. This research proposes an optimized fuzzy logic approach combined with blockchain technology to address the authentication and key agreement challenges in digital healthcare systems. The proposed solution leverages the flexibility and adaptability of fuzzy logic algorithms to handle uncertainty and imprecision in authentication decisions. By employing fuzzy logic, the system can effectively minimize false positives and false negatives, enhancing the robustness against adversarial attacks. Moreover, the integration of blockchain technology provides a decentralized and tamper-proof infrastructure for securely storing and managing authentication and key agreement data. This ensures transparency and trust in the system, mitigating the risks of unauthorized access and data manipulation. The blockchain-based architecture also enables efficient resource utilization and scalability, allowing the system to handle authentication requests in a timely manner, even in large-scale digital healthcare environments.The proposed method is evaluated by using the NIST Special Database 302 and it shows superior performance compared to existing methods, with minimum False Rejection Rate (FRR), False Acceptance Rate (FAR), and response time. Moreover, the proposed method minimizes communication overhead during the authentication process and resists different cyber attacks including a Replay attack, Man-in-the-middle attack, Denial of Service (DoS) attack, and Impersonation attack. The proposed method achieves excellent performance in terms of security, efficiency, and resistance to various cyber-attacks, making it a promising approach for secure data sharing in P2P cloud environments.
Chlorophyll Content and Photosynthetic Activity of Phytoplankton in Reservoirs of the Volga River (Russia)
Authors: Mineeva Natalya Mikhailovna , Semadeni Ivan Vladimirovich
Published: July 2023

Using the fluorescent method in the modification of Krasnoyarsk State University, we study development (as chlorophyll content, ∑CHL) and photosynthetic activity of phytoplankton in seven large flat reservoir of the Volga River cascade (Russia) in August 2915–2017. In period of maximal warming of water, average ∑CHL varied in limits of 19.4–33.7 μg L–1 in the Upper Volga, 8.5–27.8 μg L–1 in the Middle Volga, and 5.2–11.3 μg L–1 in the Lower Volga. Photosynthetic activity coefficient (PhAC) varied mostly in limits of 0.12–0.59 with average of 0.22–0.38 and only in 2017 decreased to minimal <0.10 and average <0.20. The average PhAC values shows the normal physiological state of the phytoplankton of the Upper Volga during all periods of observation, occasional decrease of PhAC in the Middle Volga, and low photosynthetic activity in the Lower Volga. A decrease in the average ∑Chl and PhAC in 2017 was under cyclonic windy weather with a large amount of precipitation, low solar radiation, and large volume of flow. Trend towards a decrease in ∑CHL, like decrease in PhAC from the Upper Volga to the Lower Volga is explained by increasing in the flow rate and volume of runoff downstream the Volga River.
Elevating Cultural Tourism Recommendations: Exploring the Design and Evaluation of ACUX-R’s Mobile Graphical User Interface
Authors: Konstantakis Markos , Aliprantis John , Alexandridis Georgios , Caridakis George
Published: July 2023

This article presents the graphical user interface of the ACUX-R mobile recommendation system, tailored for the cultural tourism domain. ACUX-R offers personalized recommendations based on visiting preferences, augmenting the overall user experience. Building upon a comprehensive methodology and recommendation algorithms from previous work, this contribution focuses on the user interface aspects of the ACUX-R by highlighting key design considerations, user interface elements and functionalities that contribute to an effective and engaging user experience. In an effort to evaluate the proposed interface, an initial case study with a dataset consisting of points of interest from the City of Athens, Greece has been performed. In the framework of the aforementioned study, the proposed user interface attained high ratings with respect to inspiring, exciting, interesting, and enthusiastic user experiences.
Wood Composite Using Undifferentiated Biomass Resulting from Forest Cleaning
Authors: Fernandes Sónia , Logvina Yuliya , Silva Luís , Silva Joaquim Esteves da
Published: July 2023

Keywords: Wood residuals; Forest biomass; Wood composite; Wood floor; Life Cycle Assessment.
Dissecting Airborne Allergens
Authors: Torres-Borrego Javier , Sanchez-Solis. Manuel
Published: July 2023

Asthma is a heterogeneous and very complex group of diseases, which includes different clinical phenotypes depending on symptoms, progression, exacerbation pattern or response to treatment among other characteristics. The allergic phenotype is the most frequent, especially in pediatric asthma. It is characterized by sensitization (production of specific IgE) to allergens, and frequent comorbidity with rhinitis and atopic dermatitis. An allergen is a substance that triggers the production of specific IgE antibodies in susceptible individuals, who present symptoms that will depend on the type and intensity of the allergenic load and the tissue where the interaction occurs. Airborne allergens cause their effects in the respiratory tract and eyes, and can be indoor or outdoor, perennial or seasonal. Although allergens such as mites, pollens or animal dander are generally considered as a single particle, it is important to note that they contain different molecules which could trigger distinct specific IgE molecules on different patients.The key points that a physician who treats asthma should be aware of are:
Pharmacologic Ascorbate and Dnmt Inhibitors Increase Duox Expression and Peroxide-Mediated Toxicity in Pancreatic Cancer
Authors: Steers Garett J. , O’Leary Brianne R. , Du Juan , Wagner Brett A. , Carroll Rory S. , Domann Frederick E. , Goswami Prabhat C. , Buettner Garry R. , Cullen Joseph J.
Published: July 2023

Recent studies have demonstrated an important role for vitamin C in the epigenetic regulation of cancer-related genes via DNA demethylation by the ten-eleven translocation (TET) methylcytosine dioxygenase enzymes. DNA methyltransferase (DNMT) reverses this, increasing DNA methylation and decreasing gene expression. Dual oxidase (DUOX) enzymes produce hydrogen peroxide (H2O2) in normal pancreatic tissue but are silenced in pancreatic cancer (PDAC). Treatment of PDAC with pharmacologic ascorbate (P-AscH-, intravenous, high dose vitamin C) increases DUOX expression. We hypothesized that inhibiting DNMT may act synergistically with P-AscH- to further increase DUOX expression and cytotoxicity of PDAC. PDAC cells demonstrated dose-dependent increases in DUOX mRNA and protein expression when treated with DNMT inhibitors. PDAC cells treated with P-AscH- + DNMT inhibitors demonstrated increased DUOX expression, increased intracellular oxidation, and increased cytotoxicity in vitro and in vivo compared to either treatment alone. These findings suggest a potential therapeutic, epigenetic mechanism to treat PDAC.
Nutritional status in children with cholestasis: diagnostic approaches and correction possibilities
Authors:   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Strokova T.V. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Bagaeva M.E. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Pavlovskaya E.V. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Zubovich A.I. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation, Taran N.N. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Abdulmanapova Z.A. ,   Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation
Published: July 2023

Cholestasis is associated with various chronic liver diseases both in childhood and in adulthood. Stagnation of bile and its insufficient secretion into the digestive tract cause malabsorption of fats and fat-soluble vitamins. Increased energy requirements and inadequate energy intake lead to eating disorders, which are especially dangerous in childhood. Weight and height deficits in children with cholestasis increase the risk of complications and accelerate the progression of the disease. A comprehensive assessment of nutritional status using all available methods allows timely initiation of correction of the detected disorders. This article presents current approaches to the diagnosis of nutritional status disorders and features of diet therapy in children with chronic liver diseases occurring with cholestasis. Key words: cholestasis, children, malabsorption, diet therapy, nutritional status
Non-celiac gluten sensitivity: a diagnostic challenge in pediatrics
Authors:   Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan, Azizova G.K. , Kamilova A.T. ,   Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan, Umarnazarova Z.E. ,   Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan, Abdullaeva D.A. ,   Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan, Geller S.I. ,   Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan, Azimova N.D. ,   Republican Specialized Scientific and Practical Medical Center of Pediatrics, Tashkent, Uzbekistan
Published: July 2023

The possibility of a causal relationship between gluten intake and the development of symptoms in the absence of celiac disease (CD) and wheat allergy (WA) has recently gained new scientific interest and includes a condition known as non-celiac gluten sensitivity (NCGS). To date, NCGS has been widely described in adults, whereas there is little information about this pathology in pediatric practice. This article presents a clinical case of NCGS in a 6-year-old girl who was admitted to the gastroenterology department of the Republican Specialized Scientific and Practical Medical Center of Pediatrics (Republic of Uzbekistan) with complaints of abdominal pain, bloating, weight loss, liquid stools, headaches, and fatigue. The complaints appeared 5 months before hospitalization. Antibodies to tissue transglutaminase IgA were within reference ranges, specific IgE antibodies to wheat and gluten were not elevated. A biopsy from the distal duodenum revealed Marsh-Oberhuber 1 lesions. The patient was switched to a gluten-free diet (GFD) with suspected NCGS. At week 4 of the diet, an improvement was noted, but abdominal bloating persisted. An intolerance to components such as fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) was suspected. The use of the FODMAP diet significantly improved the condition. The reintroduction of gluten after 6 weeks resulted in a recurrence of symptoms, confirming the diagnosis of NCGS. Given that the number of gluten-related diseases is increasing, and not much is known about NCGS, we decided to present this case to raise awareness and questions regarding diagnosis, the need for specific monitoring, and treatment. Key words: FODMAP, gluten, children, non-celiac gluten sensitivity, celiac disease
Opioid Use in Surgical Management in Musculoskeletal Oncology
Authors: Gazendam Aaron M. , Ghert Michelle , Gundle Kenneth R. , Hayden James B. , Doung Yee-Cheen ,   on behalf of the PARITY Investigators
Published: July 2023

Background:

Opioid prescribing in the context of orthopaedic surgery has been recognized as having a critical role in the ongoing opioid epidemic. Given the negative consequences of chronic opioid use, great efforts have been made to reduce both preoperative and postoperative opioid prescribing and consumption in orthopaedic surgery. Musculoskeletal oncology patients represent a unique subset of patients, and there is a paucity of data evaluating perioperative opioid consumption and the risk for chronic use. The objective of the present study was to describe opioid consumption patterns and evaluate predictors of chronic opioid use in musculoskeletal oncology patients undergoing limb-salvage surgery and endoprosthetic reconstruction.

Methods:

The present study was a secondary analysis of the recently completed PARITY (Prophylactic Antibiotic Regimens in Tumor Surgery) trial and included musculoskeletal oncology patients undergoing lower-extremity endoprosthetic reconstruction. The primary outcome was the incidence of opioid consumption over the study period. A multivariate binomial logistic regression model was created to explore predictors of chronic opioid consumption at 1 year postoperatively.

Results:

Overall, 193 (33.6%) of 575 patients were consuming opioids preoperatively. Postoperatively, the number of patients consuming opioids was 82 (16.7%) of 492 at 3 months, 37 (8%) of 460 patients at 6 months, and 28 (6.6%) of 425 patients at 1 year. Of patients consuming opioids preoperatively, 12 (10.2%) of 118 had continued to consume opioids at 1 year postoperatively. The adjusted regression model found that only surgery for metastatic bone disease was predictive of chronic opioid use (odds ratio, 4.90; 95% confidence interval, 1.54 to 15.40; p = 0.007). Preoperative opioid consumption, older age, sex, longer surgical times, reoperation rates, and country of origin were not predictive of chronic use.

Conclusions:

Despite a high prevalence of preoperative opioid use, an invasive surgical procedure, and a high rate of reoperation, few patients had continued to consume opioids at 1 year postoperatively. The presence of metastases was associated with chronic opioid use. These results are a substantial departure from the existing orthopaedic literature evaluating other patient populations, and they suggest that specific prescribing guidelines are warranted for musculoskeletal oncology patients.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Incidence of and Risk Factors for Thromboembolism After Endoprosthetic Reconstruction in Musculoskeletal Oncology Patients
Authors: Sabharwal Samir , LiBrizzi Christa L. , Forsberg Jonathan A. , Morris Carol D. , Levin Adam S. ,   on behalf of the PARITY Investigators
Published: July 2023

Background:

The aim of the present study was to assess the incidence of and risk factors for thromboembolic events—including assessment of the intraoperative use of tranexamic acid and postoperative use of chemical thromboprophylaxis—in patients undergoing operative treatment of primary bone or soft-tissue sarcoma or oligometastatic bone disease.

Methods:

This study was performed as a secondary analysis of prospective data collected from the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) randomized controlled trial, which included 604 patients ≥12 years old who underwent surgical resection and endoprosthetic reconstruction for either primary bone or soft-tissue sarcoma or oligometastatic disease of the femur or tibia. We determined the incidence of thromboembolic events in these patients and evaluated potential risk factors, including patient age, sex, antibiotic treatment group, type of tumor (i.e., primary bone or soft-tissue sarcoma or metastatic bone disease), intraoperative tranexamic acid, tourniquet use, operative time, pathologic characteristics (i.e., American Joint Committee on Cancer grade, vascular invasion, and percent necrosis), postoperative chemical thromboprophylaxis regimen, and surgical site infection. Continuous variables were assessed with use of the Student t test. Categorical variables were assessed with use of the Pearson chi-square test, except when the expected cell counts were <5, in which case the Fisher exact test was utilized. Significance was set at 0.05.

Results:

Postoperative thromboembolic events occurred in 11 (1.8%) of 604 patients. Patients who experienced a thromboembolic event had a significantly higher mean (± standard deviation) age (59.6 ± 17.5 years) than those who did not experience a thromboembolic event (40.9 ± 21.8; p = 0.002). Patients randomized to the long-term antibiotic group had a significantly higher incidence of thromboembolic events (9 of 293; 3.1%) than those randomized to the short-term antibiotic group (2 of 311; 0.64%; p = 0.03). Neither intraoperative tranexamic acid nor postoperative chemical thromboprophylaxis were significantly associated with the occurrence of a thromboembolic event.

Conclusions:

Although relatively rare in the PARITY cohort, thromboembolic events were more likely to occur in older patients and those receiving long-term prophylactic antibiotics. Intraoperative tranexamic acid and postoperative chemical thromboprophylaxis were not associated with a greater incidence of thromboembolic events.

Level of Evidence:

Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
Does the Use of Negative Pressure Wound Therapy and Postoperative Drains Impact the Development of Surgical Site Infections?
Authors: LiBrizzi Christa L. , Sabharwal Samir , Forsberg Jonathan A. , Leddy Lee , Doung Yee-Cheen , Morris Carol D. , Levin Adam S. ,   on behalf of the PARITY Investigators
Published: July 2023

Background:

Surgical site infections (SSIs) represent a major complication following oncologic reconstructions. Our objectives were (1) to assess whether the use of postoperative drains and/or negative pressure wound therapy (NPWT) were associated with SSIs following lower-extremity oncologic reconstruction and (2) to identify factors associated with the duration of postoperative drains and with the duration of NPWT.

Methods:

This is a secondary analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial, a multi-institution randomized controlled trial of lower-extremity oncologic reconstructions. Data were recorded regarding the use of drains alone, NPWT alone, or both NPWT and drains, including the total duration of each postoperatively. We analyzed postoperative drain duration and associations with tourniquet use, intraoperative thromboprophylaxis or antifibrinolytic use, incision length, resection length, and total operative time, through use of a linear regression model. A Cox proportional hazards model was used to evaluate the independent predictors of SSI.

Results:

Overall, 604 patients were included and the incidence of SSI was 15.9%. Postoperative drains alone were used in 409 patients (67.7%), NPWT alone was used in 15 patients (2.5%), and both postoperative drains and NPWT were used in 68 patients (11.3%). The median (and interquartile range [IQR]) duration of drains and of NPWT was 3 days (IQR, 2 to 5 days) and 6 days (IQR, 4 to 8 days), respectively. The use of postoperative drains alone, NPWT alone, or both drains and NPWT was not associated with SSI (p = 0.14). Increased postoperative drain duration was associated with longer operative times and no intraoperative tourniquet use, as shown on linear regression analysis (p < 0.001 and p = 0.03, respectively). A postoperative drain duration of ≥14 days (hazard ratio [HR], 3.6; 95% confidence interval [CI], 1.3 to 9.6; p = 0.01) and an operative time of ≥8 hours (HR, 4.5; 95% CI, 1.7 to 11.9; p = 0.002) were independent predictors of SSI following lower-extremity oncologic reconstruction.

Conclusions:

A postoperative drain duration of ≥14 days and an operative time of ≥8 hours were independent predictors of SSI following lower-extremity oncologic reconstruction. Neither the use of postoperative drains nor the use of NPWT was a predictor of SSI. Future research is required to delineate the association of the combined use of postoperative drains and NPWT with SSI.

Level of Evidence:

Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Perbedaan Pemahaman Konsep Matematika Antara Penggunaan Metode Talking Stick Dan Pair Check Ditinjau Dari Gaya Belajar Siswa
Authors: Annurwanda Pradipta , Friantini Rizki Nurhana
Published: July 2023

Abstract— This study aims to determine the differences in understanding the concepts ofmathematics subjects from each learning method, learning style and the interaction of both.This research is a quantitative research with a 3x3 factorial design. The population in thisstudy were all eighth grade students of Maniamas Ngabang Middle School 2019/2020academic year totaling 105 people. Samples were taken by cluster random samplingtechnique with a total sample of 78 people. The instrument used was a test instrument tomeasure understanding of mathematical concepts and questionnaire instruments to measurestudent learning styles. The data analysis technique uses two-way variance (two way ANOVA)with a significant level of 5%. Based on the results of the calculation of the hypothesis testcan be concluded (1) There are differences in understanding the concept of mathematicssubjects between the use of the Talking Stick method, Pair Check and conventional materialrelations and functions, namely (a) Students taught by the Talking Stick and Pair Checkmethod produce understanding mathematical concepts the same is good, (b) Students taughtwith the Talking Stick method are better than students taught with conventional methods and(c) Students taught by the Pair Check method are better than students taught by conventionalmethods. (2) There is no difference in understanding of the concepts of mathematical subjectsbetween students who have visual, auditory and kinesthetic learning styles and (3) There is nointeraction of understanding mathematical concepts between each learning method andlearning style.