bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizacija spletne rešitve v ogrodju Next.js z Google Lighthouse
Authors: Pahole Leon
Published: September 2023

Raziskave kažejo, da so strani, ki se hitro naložijo, bolj optimizirane za spletne iskalnike, prijaznejše za uporabnike in bolj profitabilne. Google Lighthouse je orodje za analizo kvalitete spletnih strani, s katerim lahko med drugim izmerimo učinkovitost nalaganja strani. Učinkovitost je izmerjena na podlagi metrik, ki izražajo uporabniško izkušnjo ob nalaganju. Next.js je ogrodje za razvoj spletnih aplikacij, ki temelji na knjižnici React, pri čemer še posebej poudarja optimizacijo delovanja spletnih aplikacij, predvsem nalaganje le-teh. V prispevku smo na kratko razložili performančne metrike, ki jih meri Google Lighthouse v sklopu ocene učinkovitosti spletne strani, nato pa smo na podlagi praktičnih izkušenj predstavili naslednje Next.js tehnike za optimizacijo teh metrik: izrisovanje na strežniku, statično izrisovanje, inkrementalno statično izrisovanje, ločevanje kode, optimizacija slik, optimizacija pisav, strežniške komponente in nalaganje na zahtevo. Izkaže se, da lahko v praksi s pomočjo navedenih tehnik, v kombinaciji z meritvami iz Google Lighthouse, na enostaven in intuitiven način izboljšamo nalaganje naše spletne strani, kar vodi k boljši uporabniški izkušnji.
IIoT v oblaku za optimizacijo delovanja strojev brez večjih začetnih investicij
Authors: Kaligaro Marjan , Habjan Jure
Published: September 2023

V vse bolj tehnološko zahtevnem in konkurenčnem poslovnem okolju številna industrijska podjetja iščejo skrite rezerve za izboljšanje učinkovitosti poslovanja. Eno od takšnih področij je zagotavljanje visoke razpoložljivosti strojev, saj rezultati kažejo, da lahko s tem produktivnost povečamo tudi do nekaj deset odstotkov. Stroji so pri svojem obratovanju izpostavljeni stalnim obremenitvam, obrabi in staranju, kar vpliva na njihovo delovanje in povzroča okvare. Redno vzdrževanje in odzivanje na okvare sicer rešita del težav, a še zdaleč ne vseh. Za doseganje bistvenih izboljšav v razpoložljivosti, ki po eni strani ustvarjajo večjo dodano vrednost strojev za industrijska podjetja, po drugi strani pa prinašajo več finančnih in nefinančnih pozitivnih učinkov za proizvajalce strojev, je potrebno sodelovanje obeh strani (tako uporabnika stroja kot njegovega proizvajalca). Z vzpostavitvijo ustrezne platforme za pridobivanje, hrambo ter obdelavo operativnih podatkov lahko zagotavljamo omenjeno visoko razpoložljivost ter pravočasen odziv na težave.
Izkušnje pri skaliranju večje rešitve z zabojniki
Authors: Krajnc Andrej , Ambrožič Vojko , Štok Bojan
Published: September 2023

Sistem COBISS sestavlja več aplikacij in mikrostoritev, javnost pozna predvsem spletno aplikacijo COBISS+. Pred tremi leti smo začeli prenovo aplikacije COBISS3, ki jo knjižničarji uporabljajo za poslovanje knjižnice (zaloga, nabava, izposoja, serijske publikacije, elektronski viri, izpisi). Obstoječa verzija aplikacije je večslojna in uporablja grafični uporabniški vmesnik Java Swing. Nova generacija aplikacije COBISS4 ima spletni uporabniški vmesnik, podpira vse funkcionalnosti, ki jih ima obstoječa aplikacija, pri čemer gre za kompleksno aplikacijo z nekaj 1000 poslovnimi entitetami. Obe aplikaciji uporabljata isti zaledni strežnik, ki teče za vsako od več kot 1400 knjižnic, pri čemer za večje knjižnice teče več instanc aplikacije. Nameščanje in nadgradnja več kot 2000 instanc je v virtualnem okolju zelo zahtevna, zato smo se odločili za uporabo zabojnikov. Analizirali smo dva različna orkestratorja za zabojniško okolje. Odločili smo se za uporabo Docker Swarm, ker je namestitev in vzdrževanje precej bolj enostavno kot pri orkestratorju Kubernetes. Celotni postopek smo avtomatizirali z orodjem Ansible, delovanje aplikacij in mikrostoritev pa nadziramo in spremljamo z orodjem Prometheus. Za izenačevalnik obremenitve smo uporabili Traefik. Izkušnje pri delovanju gruče so pozitivne, prav tako je sistem zelo stabilen in obvladljiv. Načrtujemo, da bomo v prihodnje uporabili zabojnike še pri razvoju drugih aplikacij v sistemu COBISS.
Monolitne rešitve za mikrostoritvene izzive
Authors: Beranič Miroslav
Published: September 2023

V članku bom raziskal Quarkus, ogrodje za razvoj Java aplikacij. Z optimiziranimi lastnostmi delovanja ogrodje primarno cilja na razvoj Java aplikacij v oblaku. Quarkus se osredotoča na hitrost, majhen odtis pomnilnika in nizko latenco; sebe opisuje kot “supersonic subatomic Java”. Ena izmed ključnih sestavin Quarkusa je GraalVM, ki omogoča hitrejši čas zagona aplikacij in učinkovito porabo virov s pretvorbo Java kode v native obliko, brez vmesnega Java VM. To je še posebej koristno za mikrostoritvene arhitekture. V članku bom pregledal tudi konkurenčne rešitve ter primerjal prednosti Quarkusa v primerjavi z drugimi razvojnimi ogrodji za oblak. Predstavil bom preprost primer uporabe Quarkusa, da bo bralec dobil vpogled v način razvoja in delovanje. Kot praktičen primer bo opisan tudi način objave aplikacije v sistemu za upravljanje z mikrostoritvam. S celovito analizo Quarkusa in tehnologije GraalVM bo članek bralcu omogočil boljše razumevanje in uporabno ter izkoristek teh inovativnih rešitev za razvoj Java aplikacij v oblaku. Članek se lahko uporabi kot vodnik: kako lahko Quarkus izboljša izkušnje pri razvoju sodobnih oblačnih storitev in aplikacij.
Vtičnik v Grafani za napredno vizualizacijo vremenskih podatkov
Authors: Lenko Miha , Meolic Robert
Published: September 2023

V članku obravnavamo problem vizualizacije vremenskih podatkov v sklopu tehnologije dinamično ocenjevanje prenosne zmogljivosti (DLR). To je obetavna komponenta zelenega prehoda energetike, ki omogoča bolj učinkovito integracijo obnovljivih in razpršenih virov energije samo z upoštevanjem vremenskih dejavnikov, ki vplivajo na segrevanje in hlajenje posameznih elementov. SUMO je modularna rešitev za DLR podjetja Operato, ki za vizualizacijo vremenskih podatkov uporablja orodje Grafana. V standardni različici Grafane ni namenskega pogleda na podatke o vetru, ravno veter pa ima največji vpliv na delovanje algoritma in si ga uporabniki zato želijo podrobno analizirati. Veter je za razliko od večine drugih vremenskih veličin vektor, torej ima hitrost in smer. Dodatno je smer vetra omejena z domeno vrednosti od 0 do 360 stopinj. V meteorologiji se za analizo podatkov o vetru pogosto uporablja prav poseben prikaz imenovan roža vetrov, ki ga ni mogoče nadomestiti ali sestaviti z uporabo drugih grafikonov. Zato je bil izdelan nov vtičnik za Grafano. Za izvedbo naloge je bilo potrebno osnovno poznavanje jezika TypeScript, tehnologije ReactJS in formata SVG za opis vektorske grafike. Izdelana je bila kvalitetna aplikacija, ki omogoča sprotno osveževanje gradnikov in podpira uporabo različnih podatkovni virov. Vtičnik je že dosegljiv za namestitev iz uradnega kataloga.
Danuta i Daniel Olędzcy: Architektura na miarę możliwości
Authors: Ciarkowski Błażej
Published: September 2023

Biografia pary trójmiejskich architektów, Danuty i Daniela Olędzkich przedstawia obraz twórców o ponadprzeciętnych dokonaniach zawodowych, autorów obiektów, które trwale zapisały się w historii architektury polskiej XX wieku. Takie realizacje jak Grunwaldzka Dzielnica Mieszkaniowa w Gdańsku, falowce na Przymorzu, gmachy Teatru Wybrzeże czy Kieleckiego Centrum Kultury stanowią jedne z najważniejszych przykładów rodzimego budownictwa czasów Polski Ludowej. Każdy z projektów stanowi jednocześnie odrębna historię ukazującą niuanse PRL-owskiej codzienności. Książka poświęcona Danucie i Danielowi Olędzkim to nie tylko historia ich projektów i realizacji. Losy obojga są reprezentatywne dla całej generacji twórców, którzy urodzili się jeszcze w II Rzeczypospolitej, a w dorosłość wkraczali w nowych realiach powojennej Polski. Pełnię potencjału twórczego mogli ukazać w czasach Gomułkowskiej i Gierkowskiej stabilizacji, by finalnie mierzyć się z post-transformacyjną rzeczywistością. Historia dokonań Olędzkich wydaje się także ważna w świetle współczesnych losów architektonicznego dziedzictwa PRL-u. Obraz okoliczności warunkujących powstanie poszczególnych obiektów pozwala na ich pełniejszą, bardziej obiektywną ocenę, a w konsekwencji – waloryzację umożliwiającą ochronę ich szczególnych wartości.
Menopoz Dönemi Kadınların Menopoza Özgü Sıcak Basması Semptomları ile Fiziksel Aktivite Düzeylerinin Araştırılması
Authors: ERDEMİR İbrahim , SÜSLER DENİZ Arzu
Published: September 2023

Amaç: Bu çalışmada menopoz dönemi kadınlarda gelişen menopoza özgü sıcak basması semptomlarının ve fiziksel aktivite düzeyleri arasında ilişki olup olmadığını araştırmayı amaçlamaktadır.

Metaryal ve Yöntem: Çalışmanın araştırma grubunu 45-65 yaş aralığındaki 98 menopoz dönemi kadın oluşturmaktadır. Tanımlayıcı ve kesitsel türde yapılacak olan bu çalışmanın verileri Mart-Nisan 2023 tarihleri arasında Afyonkarahisar’ın Emirdağ ilçesi Kadın Kültür Evini ziyaret eden menopoz dönemdeki gönüllü kadınlardan elde edilmiştir. Araştırmada veri toplama aracı olarak katılımcılara demografik bilgi formu, fiziksel aktivite düzeylerini belirlemek için “Uluslararası Fiziksel Aktivite Anketi (IPAQ) Kısa Form”, menopoz dönemi sıcak basması hakkında veriler “Menopoza Özgü Sıcak Basması Ölçeği” kullanılarak toplanmıştır.

Bulgular: Anketlerden elde edilen veriler SPSS 27.0 paket programı ile yapılmıştır istatistiksel anlamlılık düzeyi p
Experimentos didácticos introductorios al electromagnetismo
Authors: Bolívar Cely Simón , Bolívar Suárez Alejandro
Published: September 2023

El presente texto es una propuesta de trabajo complementario al desarrollo de un curso introductorio de fundamentos de electromagnetismo. Las actividades propuestas se fundamentan en el uso de herramientas didácticas compuestas por experimentos de aula y simuladores virtuales de fenómenos físicos propios del electromagnetismo.El propósito de los autores es contribuir al mejoramiento de la enseñanza de la física, siguiendo el ejemplo de personajes premios Novel de Física, quienes “después de haber recibido este premio se dedicaron a atender problemas de enseñanza–aprendizaje”1. Los contenidos expuestos, son aplicables en la formación de futuros profesionales en campos de la ciencia y la tecnología, así como en la formación de maestros en el campo de la docencia
Plantas medicinales utilizadas en el municipio de Motavita, Boyacá
Authors: Cruz Carrillo Anastasia , Hortúa López Laura Cristina , Rodríguez Salgado Ángela Mireya
Published: September 2023

En esta obra se recopila el saber popular que algunos pobladores del municipio de Motavita, Boyacá (Colombia), tienen sobre las plantas medicinales, los nombres comunes, formas de preparación y de uso que dan a estas, así como de las enfermedades para las cuales son utilizadas. A partir de dicho conocimiento y con base en la identificación botánica de las plantas colectadas en la zona, las autoras hacen una revisión de la literatura científica que describe los metabolitos que cada una de las plantas posee, así como los efectos demostrados por las mismas o partes de ella, con lo que se logra articular el saber popular con la demostración científica. El libro viene ilustrado con imágenes de las plantas encontradas en el municipio, para facilitar su reconocimiento e identificación. La información aquí recopilada, no solo permite perpetuar el conocimiento tradicional sobre plantas medicinales, sino que abre la posibilidad de que se realicen futuras investigaciones que complementen y enriquezcan el saber existente.
La Formalización de la Propiedad Rural
Authors: Villegas Orozco William Luciano , Vega Pérez Leonel Antonio
Published: September 2023

El acceso a la propiedad de la tierra sigue siendo un tema de enorme actualidad en el país rural, por la vulnerabilidad de las comunidades rurales, la precariedad de los bienes públicos en los territorios rurales y la importancia estratégica de sus ecosistemas. Con motivo de la promulgación del Decreto Ley 902 de 2017 en mayo de 2019, el profesor emérito de la Universidad de Toronto Albert Berry, candidato al Nobel de Economía 2014 entre otras razones por sus trabajos en economía campesina, dijo en Bogotá, “Es claro que muchos pequeños agricultores requieren más tierra. Se necesita una política de acceso a la tierra, no solo a los restituidos sino a otros pequeños agricultores, que por uno u otro motivo tienen insuficiente tierra”.El documento inicia con una introducción al problema de la tenencia de la propiedad rural en Colombia, trata las diferentes tipologías de informalidad, tales como la posesión, falsa tradición y ocupación entre otras. Luego se concentra en la normatividad y presenta sus precisiones jurídicas; haciendo énfasis en los planes de ordenamiento social de la propiedad rural y por último se informa sobre las ventajas del catastro multipropósito mencionando el papel de las diferentes agencias del estado (IGAC, ANT, SNR) en el nuevo enfoque institucional.
Desregulación emocional y dependencia emocional en estudiantes universitarios de Lima Metropolitana
Authors:   , Irazabal Flores Alvaro Sebastian , Merino Vilca Mariel Cristina
Published: September 2023

La presente investigación tiene como objetivo determinar la relación entre la desregulación emocional y la dependencia emocional en estudiantes universitarios de Lima Metropolitana de 18 a 25 años. Se trabajó con una muestra de 172 participantes (M = 22.04; DE = 1.93) y se aplicó los cuestionarios de desregulación emocional y de dependencia emocional. El estudio es no experimental transversal con diseño predictivo correlacional simple. Los resultados mostraron que existen correlaciones moderadas y grandes en regulación de impulsos, falta de aceptación emocional e interferencia en conductas dirigidas a metas entre ambas variables. De modo que, la presencia de una influye y favorece el desarrollo de los rasgos característicos del otro.
Centro educativo básico especial enfocado en el retraso mental, ubicado en Trujillo
Authors:   , Abadie De Ferrari Carmen Francesca
Published: September 2023

El presente proyecto tiene como objetivo determinar las necesidades básicas para ejecutar un Centro Educativo Básico Especial enfocado en el retraso mental, ubicado en Trujillo. Para la elaboración de este proyecto se tomó en cuenta diversos aspectos, tales como la problemática, aspectos históricos, culturales, regionales objetos principales, secundarios, metodología de enseñanza dentro del centro educativo, psicólogos, aspectos sociales, urbanísticos y normativos. Asimismo, el usuario principal cuenta con una importancia relevante al momento de diseñar diversos espacios del centro educativo, este usuario debe contar con diversos elementos que estimulen el desarrollo visual, cognitivo, lúdico y social del alumno dentro y fuera del aula. Además, se analizó el lugar en donde será emplazado el presente proyecto, se realizó una investigación con respecto a las ventajas y desventajas que cuenta la zona, para poder obtener una óptima integración con la comunidad. A su vez, se realizó una investigación en donde se determinó los diversos usuarios que contará el centro educativo, normativa actualizada respecto a un centro educativo básico especial y programa arquitectónico el cual cuenta con una integración de residencia temporal enfocado a las familias que carecen de solvencia económica o vivan en zonas lejanas del centro educativo y requieran de un lugar donde hospedarse durante el corto periodo de tiempo. Para el desarrollo del proyecto se utilizaron libros de texto con respecto al tema, metodologías educativas de diversos autores, investigaciones profesionales y estadísticas que aproximan datos de los niños que presentan a nivel nacional.
Casa de retiro para la diócesis de Carabayllo en Santa Rosa de Quives
Authors:   , Pariasca Mendoza Jherson Javier
Published: September 2023

El presente documento que sustenta el proyecto de título “Casa de Retiro para la Diócesis de Carabayllo en Santa Rosa de Quives”; asimismo explica los conceptos y procedimientos que se llevaron a cabo para el desarrollo y propuesta final. Además, se analiza la situación nacional de las casas de retiro de la iglesia católica, específicamente en la zona norte de Lima, denominada Diócesis de Carabayllo, debido a que posee mayor cantidad de fieles y presentan un déficit de casas de retiro. Es por ello que el proyecto arquitectónico planteado en Santa Rosa de Quives, zona perteneciente a la Diócesis, busca suplir la alta demanda que existe. El proyecto aplica los principios de Arquitectura Orgánica para integrar la propuesta con el entorno natural de Quives, en el mismo sentido utiliza los patrones de la Arquitectura Biofílica para generar una mejor experiencia al usuario en el desarrollo del retiro espiritual, generado por el diseño que interioriza la naturaleza.
Chronic fatigue syndrome – challenge in diagnosis and management: a literature review
Authors: Nieciecka Adrianna , Tomys-Składowska Julia , Lamch Magdalena , Jabłońska Monika , Błasik Natalia , Janiszewska Marta , Wójcik-Kula Agata
Published: September 2023

Introduction. Chronic fatigue syndrome is a disease that includes a number of various symptoms, among which the most characteristic symptom is fatigue. Diagnostic criteria are not unambiguous and vary depending on the scientific society by which they were developed. The aim of this review is to discuss the phenomenon of chronic fatigue, including its diagnostic criteria, epidemiology, pathophysiology, symptoms, and pharmacological and non-pharmacological strategies.
Material and methods. 45 articles published were reviewed and placed in the PubMed and Google Scholar databases.
Results. Chronic fatigue syndrome is defined as a group of symptoms whose dominant symptom is fatigue that persists after rest for at least 6 months. The Oxford or CDC criteria are most commonly used to make the diagnosis. Statistics on prevalence are inconclusive. There are several theories of origin - infectious, immunological, neuroendocrine, bioenergetic, neurological, autonomic and genetic. Other symptoms of chronic fatigue syndrome include sleep and memory disorders or muscle and joint pain. Current treatment focuses on symptomatic treatment, including education, diet, and physical activity, as well as pharmacotherapy for pain, sleep, and cognition.
Discussion. Diagnosis and treatment of chronic fatigue syndrome undoubtedly is a medical challenge, due to non-specific symptoms, multifactorial pathogenesis and difficult to estimate prevalence of this disease. Future scientific development should focus especially on exploring the pathomechanism of CFS, which would enable the implementation of causal treatment.
Brain connectivity by single-photon emission computed tomography and graph theory: a mini-review
Authors: Sanchez-Catasus Carlos A. , Batista-García-Ramó Karla , Melie-Garcia Lester
Published: September 2023

Current neuroimaging technologies play an important role in neurological disorders. Among these technologies, nuclear medicine neuroimaging such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) play a key role. The relevance of brain SPECT is that it has lower costs and greater availability compared to brain PET. Quantitative methods used in brain SPECT are generally univariate. The main limitation of these methods is that they do not allow investigating the relationship between brain regions (i.e. connectivity). One of the multivariate methods that has proven to be useful is graph theory. In this article, we review brain connectivity modeling based on this approach applied to brain SPECT. We also include some clinical studies to illustrate the potential of this method to detect subtle changes in brain connectivity. Recent advancements in new SPECT technology detectors could be the basis for the next level of use of this analysis methodology in the near future.
Space Theory
Authors: Chen S.
Published: September 2023

The author introduces a novel theoretical framework that suggests matter and energy are both converted from curved space. In Space Theory, gravitation is generated by the flow of space, instead of being transmitted by the graviton as in String Theory. This theory also suggests that Newton's gravitational constant, denoted as G, may not be truly constant but could vary over time. The equivalent equation of space is S=Ec2=mc4, and the gravitation of hollow sphere space is Sμν=4πGm=(4/3)π((r+a)3-r3). The Space Theory also predicts that the surface gravitational acceleration of the neutron star Crab Pulsar (PSR B0531+21) is approximately 8.21924883×106 m/s2.
Dry Friction and Wear Behavior of Laser-Sintered Graphite/Carbon Fiber/Polyamide 12 Composite
Authors: Gadelmoula Abdelrasoul , Aldahash Saleh Ahmed
Published: September 2023

Carbon fiber reinforced polymers (CFRPs) are being used extensively in modern industries that require high strength-to-weight ratio such as aerospace, automotive, motorsport, and sports equipment. However, although reinforcement with carbon fibers improves the mechanical properties of polymer, this comes on the expense of abrasive wear resistance. Therefore, to efficiently utilize CFRPs in dry sliding contacts, solid lubricant is used as a filler. Further, to facilitate fabrication of objects with complex geometries, selective laser sintering (SLS) can be employed. Accordingly, in the present work, graphite-filled carbon fiber-reinforced polyamide 12 (CFR-PA12) specimens were prepared using SLS process to explore the dry sliding friction and wear characteristics of the composite. The test specimens were aligned along four different orientations in the build chamber of SLS machine to determine the orientation-dependent tribological properties. The experiments were conducted using pin-on-disc tribometer to measure the coefficient of friction (COF), interface temperature, friction-induced noise, and specific wear rate. In addition, scanning electron microscopy (SEM) of tribo-surfaces was conducted to specify the dominant wear pattern. The results indicated that the steady state COF, contact temperature, and wear pattern of graphite-filled CFR-PA12 are orientation-independent, and that the contact temperature is likely to approach an asymptote far below the glass transition temperature of amorphous PA12 zones, thus eliminating the possibility of matrix softening. Additionally, the results showed that the Z-oriented specimen exhibits the lowest level of friction-induced noise along with the highest wear resistance. Moreover, SEM of tribo-surfaces determined that abrasive wear is the dominant wear pattern.
Artificial Self-Consciousness In Over Time
Authors: mousavi seyed kazem
Published: September 2023

Consciousness results from comprehending the living creature from its existence in time and space. Thought and consciousness are distinguishing factors between humans and machines having artificial intelligence. No algorithm has been offered for artificial self-awareness based on Thinking. Previous studies have not studied the relationship between consciousness, thinking and time. In this study, the relationship between consciousness, thinking, memories and speech over time has been studied. A deep logical connection exists between consciousness, thinking, and time. An algorithm can be designed for artificial consciousness based on this research findings.
Advances in Delivery Across the Blood-Brain Barrier: A Case-Study Perspective
Authors: Niazi Sarfaraz K. , Magoola Matthias
Published: September 2023

Device-mediated, non-invasive drug delivery across the blood-brain barrier (BBB) represents a significant advancement in treating neurological diseases. The BBB is a tightly packed layer of endothelial cells that shields the brain from harmful substances in the blood, allowing necessary nutrients to pass through. It is a highly selective barrier, which poses a challenge to delivering therapeutic agents into the brain. Several non-invasive techniques and devices have been proposed or investigated to enhance drug delivery across the BBB. This paper presents the current state of the art and case studies that address the pharmacology, technology, delivery systems, regulatory approval, ethical concerns, and future possibilities.
Durability Analysis of CFRP Adhesive Joints: A Study Based on Entropy Damage Modelling Using FEM
Authors: Li Yutong , Deng Huachao , Takamura Maruri , Koyanagi Jun
Published: September 2023

Experimental methodologies for fatigue lifetime prediction are time-intensive and susceptible to environmental variables. While the cohesive zone model is popular for predicting adhesive fatigue lifetime, entropy-based methods have also shown promise. This study aims to provide an understanding of the durability characteristics of CFRP adhesive joints by incorporating an entropy damage model within the context of the finite element method (FEM), examined the effects of different adhesive layer thicknesses on SLS models. As the adhesive layer increased in thickness, DAMAGE VARIABLES initially rose and then declined, peaking at 0.3mm. This finding provides crucial understanding into the stress behavior at the resin-CFRP interface and the resin's fatigue mechanisms.
Minimally Invasive Hypoglossal Nerve Stimulator Enabled by ECG Sensor and WPT to Manage Obstructive Sleep Apnea
Authors: Xia Fen , Li Hanrui , Li Yixi , Liu Xing , Xu Yankun , Fang Chaoming , Hou Qiming , Lin Siyu , Zhang Zhao , Yang Jie , Sawan Mohamad
Published: September 2023

Hypoglossal nerve stimulator (HGNS) is a minimally invasive device used for treating obstructive sleep apnea (OSA). The conventional implantable HGNS is a device that consists of a stimuli generator, a breathing sensor, and electrodes connected to the hypoglossal nerve via leads. However, this implant is bulky and causes significant trauma. In this paper, we propose a minimally invasive HGNS based on an electrocardiogram (ECG) sensor and a wireless power transfer (WPT), consisting of a wearable breathing monitor and an implantable stimulator. The breathing external monitor utilizes an ECG sensor to identify abnormal breathing patterns associated with OSA with 88.68$\%$ accuracy, achieved through the utilization of a Convolutional Neural Network (CNN) algorithm. With a skin thickness of 5mm and a receiving coil diameter of 9mm, the power conversion efficiency was measured at 31.8$\%$. The implantable device, on the other hand, is composed of a front-end CMOS Power Management Module (PMM), a Binary Phase Shift Keying (BPSK)-based data demodulator, and a bipolar biphasic current stimuli generator. The PMM, with a silicon area of 0.06 $mm^2$ (excluding pads), demonstrates a power conversion efficiency of 77.5$\%$ when operating at a receiving frequency of 2 MHz. Furthermore, it offers three-voltage options (1.2V, 1.8V, and 3.1V). Within the data receiver component, a low-power BPSK demodulator has been ingeniously incorporated, consuming only 42 $\mu$W when supplied with a voltage of 0.7V. The performance is achieved through the implementation of the self-biased phase-locked loop (PLL) technique. The stimuli generator delivers biphasic constant currents, providing a 5-bit programmable range spanning from 0 to 2.4 mA. The functionality of proposed ECG and WPT-based HGNS was validated, representing a highly promising solution for the effective management of OSA, all while minimizing trauma and space requirements.
Comparison of Cardiometabolic and Psycho-Affective Responses in Individual and Small Group Aerobic Training with Prescribed and Self-Selected Intensity
Authors: Silva Carlos Eduardo Rosa , Garcia Alessandro Barreta , Santana Wilian Jesus , Pinto Luiz Gustavo , Lima Leonardo Emmanuel , Dias Helton Magalhaes , Zanetti Marcelo Callegari , Jr. Aylton Figueira
Published: September 2023

Self-selecting the intensity of aerobic training is a perspective that allows practitioners to develop autonomy (choice of pace), improve physical fitness and achieve weight loss. To compare the effect of four aerobic training protocols on cardiometabolic and psycho-affective responses in physically inactive adult men and women. The sample consisted of 11 individuals aged 56 ± 10 years and BMI 29.2 ± 2.4 kg/m2 performed four different treadmill aerobic training protocols, including: 1-individual with self-selected intensity (ISS), 2-individual with prescribed intensity (IPI) (64-76% of HR max), 3-small group with self-select. selected intensity (SGS) and 4-small group prescribed intensity (SGP) (64-76% of HR max). Heart rate (HR), lactate (LACT), perceived exertion (RPE), affective response (FS), activation scale (FAS), enjoyment (PACES) and intention to repeat the session (INT) were analyzed. Statistical analysis used ANOVA with Tukey's post hoc test (p<0.05). HR, LACT and RPE analyzes did not show significant differences between protocols. The FS showed a smaller decline in the SI protocol (p<0.05), and the intention to repeat the training session was greater in the SI protocol (p<0.05). Conclusion: The data allow us to conclude that the SI training protocol produced superior results in affective response, pleasure and intention to repeat the session.
Application of Advanced Design Methods of “Design for Additive Manufacturing” (DfAM) to the Process of Development of Components for Mobile Machines
Authors: Gulan Ladislav , Korec Andrej , Holub Peter , Chovančíková Viktória , Nagy Miroslav , Nagy Martin
Published: September 2023

The solved research problem is oriented to the implementation of advanced methods of component design and their sophisticated use in the ever-advancing additive manufacturing. Based on the stated objectives, the research was divided into several parts. Initially, the methods and principles of design in additive manufacturing were evaluated and investigated, from which the intent was subsequently defined and the DfAM method in the component design and development process was determined. The given design method, namely topology optimization (TO), was applied to multiple development and production cycles of additive manufacturing parts to validate the research conclusions. In this paper, the procedure for a specific part or component assembly is shown. By evaluating the developed design procedure using the TO method included in the design process, the conclusions are positive in terms of both time savings and properties of the designed part such as strength and weight parameters. The given findings need to be further developed by implementing on specific product lines for increasing the efficiency of the developed design methodology.
Harvest Season and Morphological Variation of Canistel (Pouteria campechiana) Fruits and Leaves Collected in Different Zones of Mexico
Authors: Granados-Vega Karen M. , Evangelista-Lozano Silvia , Escobar-Arellano Sandra L. , Rodríguez-García Tomás , Pérez-Barcena José F. , Cruz-Castillo Juan G.
Published: September 2023

Canistel (Pouteria campechiana (Kunth) Baehni) (yellow sapote, canistel). Originally from Mexico, the fruit is edible, and the tree is used as an ornamental and medicinal plant. Descriptive studies were carried out with the objective of morphologically characterizing the fruits and leaves of trees located in different regions of Mexico to select outstanding specimens and propose their massive reproduction. The trees were selected in three zones. In zone 2 from flower anthesis to harvest 11 months, fruits with 3 seeds, greater weight (180 to 330 g) and quantity of pulp (198.88 g), subglobose shape, total soluble solids 33 %. The fruits of zone 1 at harvest 8 months and zone 3 took 9 months to be harvested, in the rest of the characteristics evaluated were exceeded by the fruits of zone 2. To characterize the canistel (P. campechiana) leaf and identify accessions or cultivars, the three main variables, according to the principal component analysis were: leaf area, perimeter, and minor diameter. The three zones where canistel fruits and leaves were characterized are important and can be recommended for propagation in zones with favorable climatic conditions for fruiting in tropical and subtropical regions of Mexico.
Generalized Chi and Eta Cross Helicities in Non-Ideal Magnetohydrodynamics
Authors: Sharma Prachi , Yahalom Asher
Published: September 2023

We study the generalized χ and η cross helicities for non-ideal non-barotropic magnetohydrodynamics (MHD). χ and η, the additional label translation symmetry group, have been used to generalize the cross helicity in ideal flows. Both new helicities are additional topological invariants of ideal MHD. To study there behaviour in non-ideal MHD, we derive the time derivative of both helicities using the non-ideal MHD equations taking viscosity, finite resistivity and heat conduction into account. Physical variables are divided into ideal and non-ideal quantities separately during the mathematical analysis for simplification. The analytical results indicate that χ and η cross helicities are not strict constant of motion in the non-ideal MHD and show the rate of dissipation which is compared to the dissipation of other topological constants of motion.
Phase Shift and Infinitesimal Wave Energy Loss Equations
Authors: Thakur Soumendra Nath , Bhattacharjee Deep
Published: September 2023

The research paper provides a mathematical framework for understanding phase shift in wave phenomena, bridging theoretical foundations with real-world applications. It emphasizes the importance of phase shift in physics and engineering, particularly in fields like telecommunications and acoustics. Key equations are introduced to explain phase angle, time delay, frequency, and wavelength relationships. The study also introduces the concept of time distortion due to a 1° phase shift, crucial for precise time measurements in precision instruments. The research also addresses infinitesimal wave energy loss related to phase shift, enriching our understanding of wave behavior, and impacting scientific and engineering disciplines.
Fuzzy Normed Linear Spaces Generated by Linear Functionals
Authors: Kouhsari F. , Khoddami A. R.
Published: September 2023

For a nonzero normed linear space X‎, ‎we will define some different classes of fuzzy norms on X generated by linear and bounded linear functionals‎. ‎Also separate continuity of the elements of each class are investigated‎. ‎The aim of this research is to introduce a source of examples and counterexamples in the field of fuzzy normed spaces‎.
The Mycobacterium tuberculosis: A Silent Killer
Authors: Oliveira Heloisa Veríssimo de , Ferreira Joiciane , Matta Ana Carolina , Oliveira Marcelo
Published: September 2023

Mycobacterium tuberculosis is the agent of tuberculosis, one of the most important infectious diseases in the world. This microorganism stands out from other bacteria, not only for its extremely high infection capacity, but also for its cellular characteristics that include an extremely resistant and hydrophobic cellular parade the passage of antibiotics. An incredible ability to adapt to adverse conditions inside the host as well as its vast arsenal of virulence factors that allow its survival within the inhospitable environment within the macrophage can be highlighted. This review aims to discuss several aspects of MTB microbiology, genetics, and physiology. We will address in this review details of the metabolism of MTB that allows it to replicate in the active phase and remain viable during latency, as well as the characteristics of its cell wall that contribute to the blockade of the immune response and its resistance to antibiotics.
A New Theoretical Finding Relating Subatomic Particles’ Mass to the Square of the Magnetic Flux Quantum Provides a New Interpretation for Mass
Authors: Fried Israel
Published: September 2023

The motivation for investigating the issues presented in this article stemmed from a need to understand better the relationship in long-established physics formulas and extract the information they provided using conventional methods. Based on the definition of magnetic flux quantization, which is based on a combination of fundamental physical constants, the Planck constant, and the particle’s elementary charge, this work explores the results that arise when this equation is combined with the equation of the Bohr-level electrostatic force acting on the electron, which leads to a new mathematical relationship between the combined expressions. The new relationship yields novel theoretical findings related to the known universal constants. Following this insight, the formalism developed in this paper indicates that the mass of the electron and other subatomic particles is associated with the magnitude of the square of the magnetic flux quantum, which makes up the particle. This conclusion is not as strange as it may seem, as the square of the magnetic flux quantum appears in the context of magnetic energy in a current loop and, according to Einstein’s special theory of relativity, energy is equivalent to mass. The theoretical results are in full accordance with experimental results published by NIST CODATA 2018 that I’ve used, which validates the existence of the relationship. The distinction between gravitational and inertial mass, which are ultimately equivalent, indicates that the relationship between the particle’s mass and the square of the magnetic flux quantum is another aspect of mass originating from the particle’s interaction with the Higgs field.
Machine Learning Applications to Identify Young Offenders Using Data from Cognitive Function Test
Authors: Bonfante María Claudia , Montes Juan Contreras , Pino Mariana , Ruiz Ronald , González Gabriel
Published: September 2023

Machine Learning techniques can be used to identify whether deficits in cognitive functions contribute to antisocial and aggressive behavior. This paper initially presents the results of tests conducted on delinquent and non-delinquent youths to assess their cognitive functions. The dataset extracted from these assessments, consisting of 37 predictor variables and one target. was used to train three algorithms that aim to predict whether the data corresponds to that of a young offender or a non-offending youth. Prior to this, statistical tests were conducted on the data to identify characteristics that exhibited significant differences in order to select the most relevant features and optimize the prediction results. Additionally, other feature selection methods, such as Boruta, RFE, and Filter, were applied, and their effects on the accuracy of each of the three machine learning models used (SVM, RF, and KNN) were compared. 80% of the data were utilized for training, while the remaining 20% were used for validation. The best result was achieved by the K-NN model trained with 19 features selected by the Boruta method, followed by the SVM model trained with 24 features selected by the filter method.
Technical validation of a fully integrated NGS platform in real-world practice of Italian referral institution
Authors: De Luca Caterina , Pepe Francesco , Russo Gianluca , Nacchio Mariantonia , Pisapia Pasquale , Russo Maria , Conticelli Floriana , Palumbo Lucia , Scimone Claudia , Cozzolino Domencio , Gragnano Gianluca , Iaccarino Antonino , Troncone Giancarlo , Malapelle Umberto
Published: September 2023

Aims: To date, precision medicine plays a pivotal role in the clinical administration of solid tumor patients. In this scenario, a rapidly increasing number of predictive biomarkers have been approved in diagnostic practice or are currently investigated in clinical trials. A pitfall in the molecular tests is the diagnostic routine sample available to analyze predictive biomarkers; scant tissue sample often represents the only diagnostical source of nucleic acids to assess molecular analysis. At the sight of these critical issues, Next Generation Sequencing (NGS) platforms emerged as referral testing strategy for molecular analysis of predictive biomarkers in routine practice but high-skilled personnel, extensive working-time drastically impact on the widespread diffusion of this technology in diagnostic setting. Here, we technically validate a fully integrated NGS platform on diagnostic routine tissue samples previously tested with NGS based diagnostic workflow by a referral institution.
Methods: A retrospective series of n=64 samples (n=32 DNA, n=32 RNA samples), previously tested using a customized NGS assay (SiRe™ and SiRe fusion) were retrieved from internal archive of University of Naples Federico II. Each sample was tested by adopting Oncomine Precision Assay (OPA), able to detect 2769 molecular actionable alterations [hot spot mutations, copy number variations (CNV) and gene fusions on fully integrated NGS platform (Genexus, Thermofisher Scientifics. (26,27) Concordance rate between these technical approaches was carried out.
Results: Genexus system successfully carried out molecular analysis in all instances. A concordance rate of 96.9% (31 out of 32) was observed between OPA and SiRe™ panel both for DNA and RNA based analysis. A negative predictive value of 100% and a positive predictive value of 96.9% (62 out of 64) was assessed.
Conclusions: Fully automatized Genexus system combined with OPA (Thermofisher Scientifics) may be considered a technically valuable, saving time sequencing platform to test predictive biomarkers in diagnostic routine practice.
Virtual Reality as a Catalyst in Advancing Inclusive Design for Social and Cultural Sustainability in Architecture
Authors: Johnson Athanasius
Published: September 2023

This review article explores the convergence of virtual reality (VR) and architectural design from an inclusive lens. It underscores the crucial role of virtual reality (VR) in serving as a catalyst for the incorporation of social and cultural sustainability principles in architectural projects. The exploration is guided by inclusive design principles, which encompass several aspects such as accessibility, cultural sensitivity, diversity and inclusivity, user-centered design, and empathy. These concepts serve as the basis for further investigation into the potential of virtual reality (VR) technology to enhance and heighten these features within architectural design, therefore promoting the progress of social and cultural sustainability. The review article highlights the profound impact that virtual reality (VR) may have, going beyond mere visualisation to generate architectural experiences that are immersive, interactive, and empathetic. These experiences are designed to take into account diverse perspectives and needs.
Plant-Wide Target Metabolomics Provides A Novel Interpretation of the Changes in Chemical Ingredients during Dendrobium officinale Traditional Processing
Authors: Liu Pengfei , Fan Bei , Mu Yuwen , Tong Litao , Lu Cong , Li Long , Liu Jiameng , Sun Jing , Wang Fengzhong
Published: September 2023

The traditional processing of Dendrobium officinale (DO) is manufactured through five necessary processing steps: fresh strips, drying at 85 °C, curling, molding, and drying at 35 °C (Fengdou), and the antioxidant activity of DO were increased after processing into Fengdou. To comprehensively analyses the changing functional components, a plant-wide target metabolomics were employed. In total, 739 differential ingredients were identified in five processing treatments, mainly highlighting differences in variation with phenolic acids, flavonoids, lipids, and amino acids and their derivatives, and glycosylation of aglycone result in the up-regulation in flavonoid glycosides levels. Temperature is a key step in DO processing production. In addition, the main enrichment of specific differential ingredients was found in five different metabolic pathways, including glucosinolate biosynthesis, linoleic acid metabolism, flavonoid biosynthesis, phenylpropanoid biosynthesis, ubiquinone and other terpene quinone biosynthesis. Correlation analysis clarified that total phenols and flavonoids showed a significant positive correlation with antioxidant capacity. This study provides new insights into the influence of processing processes on DO quality, which may lead to guidance for the high-quality production of DO.
Pathogens Have Different Age/Sex Profiles for Hospital Admission and Why COVID-19 Variants Behave as If They Were ‘Different’ Pathogens
Authors: Jones Rodney P. , Ponomarenko Andrey
Published: September 2023

A recent study has suggested that the age profiles for deaths due to COVID-19 variants differs between variants and shows male/female specificity. This study demonstrates the age and sex dependency is common among human pathogens. The often-reported higher susceptibility to infections among the young and elderly is true in general but does not apply to individual pathogens. Even among different types of pneumonia there are subtle differences in the age profile. The gender ratio between pathogens likewise shows wide variation from as low as 10% female admissions for leptospirosis to around 90% for gonococcal admissions. The observed age/sex variation observed for mortality due to COVID-19 variants is an expression of a far wider phenomenon with implications to the age/sex response to vaccines. We propose that such differences are likely to be controlled by small noncoding RNAs which act as potent regulators of gene expression leading to altered cell morphology, metabolism, immune function, and response to vaccines.
Cell Glycolysis Related Gene Signature Predicts Survival of Patients with Colorectal Cancer
Authors: Zhong Jing , Chen Jingyu , Zhang Zizhen , Shao Liming
Published: September 2023

Background: Colorectal cancer (CRC) is one of the major causes of cancer-related death worldwide. Aerobic glycolysis precedes obtainment of oncogenic mutations and loss of tumor suppressors, promoting the progress of CRC. Although numerous biomarkers have been identified to be associated with prognosis and survival, a glycolysis-related gene signature in CRC has not been explored. Methods: mRNA expression profiling data in a group of CRC patients (n = 540) was extracted from the Cancer Genome Atlas (TCGA). Gene set enrichment analysis (GESA) was performed to identify gene sets that were significantly different between CRC tissues and normal tissues. Cox proportional hazards regression models were used to identify genes significantly associated with overall survival. Multivariate Cox regression analysis was used to establish a prognostic risk parameter formula. Kaplan–Meier survival estimates and the log-rank test were used to validate the significance of risk parameters for prognosis prediction. Results: Five glycolysis-related genes (ENO3, GPC1, P4HA1, IDUA, ANKZF1) were identified to be significantly associated with overall survival (AUC=0.754). Based on the five‑gene signature, patients with CRC were divided into high and low‑risk subgroups. CRC patients with a low-risk score had better survival benefits than those with a high one (P < 0.001). Conclusions: A five-gene signature associated with glycolysis for predicting the outcome of CRC patients was generated, serving as a valuable prognosis model with high efficiency and potential targeted therapy of CRC patients.
Myotendinous Thermoregulation in National Level Sprinters after a Unilateral Fatigue Acute Bout. A Descriptive Study
Authors: Cabizosu Alessio , Marín-Pagán Cristian , Martínez-Serrano Antonio , Alcaraz Pedro E. , Martínez-Noguera Francisco Javier
Published: September 2023

In the last decade there has been a growing interest in infrared thermography in the field of sports medicine in order to elucidate the mechanisms of thermoregulation. The aim of this study was to describe bilateral variations in skin temperature of the anterior thigh and patellar tendon in healthy athletes, to provide a model of baseline tendon and muscle thermoregulation in healthy sprinters following a unilateral isokinetic fatigue protocol. Fifteen healthy national-level sprinters underwent unilateral isokinetic force testing and electrostimulation in which body temperature was measured before, during, and after the protocol using an infrared thermographic camera. ANOVA detected a significant difference in the time x side interaction for patellar temperature changes (p≤0.001) and a significant difference in the time x side interaction for quadriceps temperature changes (p≤0.001). The thermal challenge produces homogeneous changes evident in quadriceps areas, but not homogeneous in tendon areas. these data show that metabolic and blood flow changes may depend on the physical and mechanical properties of each tissue.