bluuebunny/crossref_metadata_2025 huggingface dataset:
Impairment of the activin A autocrine loop by lopinavir reduces self-renewal of distinct human adipose progenitors
Authors: Ravaud Christophe , Paré Martin , Azoulay Stéphane , Dani Christian , Ladoux Annie
Published: June 2017

Maintenance of the adipose tissue requires a proper balance between self-renewal and differentiation of adipose progenitors (AP). Any deregulation leads either to fat overexpansion and obesity or fat loss and consequent lipodystrophies. Depending on the fat pad location, APs and adipocytes are heterogeneous. However, information on the pharmacological sensitivity of distinct APs to drugs known to alter the function of adipose tissue, especially HIV protease inhibitors (PIs) is scant. Here we show that PIs decreased proliferation and clonal expansion of APs, modifying their self-renewal potential. Lopinavir was the most potent PI tested. Decrease in self-renewal was accompanied by a reduced expression of the immediate early response gene IER3, a gene associated with tissue expansion. It was more pronounced in chin-derived APs than in knee-derived APs. Furthermore, lopinavir lowered the activin A–induced ERK1/2 phosphorylation. Expressions of the transcription factor EGR1 and its targets, including INHBA were subsequently altered. Therefore, activin A secretion was reduced leading to a dramatic impairment of APs self-renewal sustained by the activin A autocrine loop. All together, these observations highlight the activin A autocrine loop as a crucial effector to maintain APs self-renewal. Targeting this pathway by HIV-PIs may participate in the induction of unwanted side effects.
Framing susceptibility in a risky choice game is altered by galvanic vestibular stimulation
Authors: Preuss Nora , Kalla Roger , Müri Rene , Mast Fred W.
Published: June 2017

Recent research provides evidence that galvanic vestibular stimulation (GVS) has a modulating effect on somatosensory perception and spatial cognition. However, other vestibular stimulation techniques have induced changes in affective control and decision making. The aim of this study was to investigate the effect of GVS on framing susceptibility in a risky-choice game. The participants were to decide between a safe and a risky option. The safe option was framed either positively or negatively. During the task, the participants were exposed to either left anodal/right cathodal GVS, right anodal/left cathodal GVS, or sham stimulation (control condition). While left anodal/right cathodal GVS activated more right-hemispheric vestibular brain areas, right anodal/left cathodal GVS resulted in more bilateral activation. We observed increased framing susceptibility during left anodal/right cathodal GVS, but no change in framing susceptibility during right anodal/left cathodal GVS. We propose that GVS results in increased reliance on the affect heuristic by means of activation of cortical and subcortical vestibular-emotional brain structures and that this effect is modulated by the lateralization of the vestibular cortex.
Personaluntergrenzen in der Pflege: Ist das wirklich der Königsweg?
Authors: Napp Barbara
Published: June 2017

Das Bundesgesundheitsministerium hat beschlossen, dass es für die Pflege in Krankenhäusern eine Mindestpersonalregelung geben soll. Bis Anfang 2018 sollen sich die Bundesverbände der Krankenhäuser und die Krankenkassen zu konkreteren Zahlen äußern. Geschieht das nicht, soll es eine zentrale Regelung geben.
Lateral Crural Tensioning for Refinement of the Nasal Tip and Increasing Alar Stability: A Case Series
Authors: Foulad Allen , Volgger Veronika , Wong Brian
Published: June 2017

The objective of this study was to discuss the technical details and our experiences with lateral crural tensioning (LCT) in both functional and aesthetic rhinoplasties. A retrospective medical review was completed for all patients who underwent rhinoplasty with LCT from the years 2011 to 2014. The indications for LCT included correction of lateral crural convexity, boxy tip geometry, and dynamic collapse of the external nasal valve. The details of the rhinoplasty procedure and complications were evaluated. A total of 114 LCT rhinoplasty cases were included in this series. The most common adjunctive maneuvers included placement of spreader grafts (92% of cases) and alar rim grafts (78% of cases). Conventional classic cephalic trim was not performed in any subjects and conservative paradomal cephalic trim was performed in 48% of cases. As experience with the technique progressed, the use of onlay tip grafts decreased and the use of articulated rim grafts increased. Indications for revision were dissatisfaction with cosmetic outcome (4.4% of cases) and nasal obstruction (0.9% of cases). LCT combines traditional lateral crural steal with the use of a caudal septal extension graft to refine the broad tip and increase stability of the alar lobule. This maneuver is essentially cartilage sparing and does not rely on extensive grafting maneuvers that can reduce airway area.
Upper Limbs Trauma in Pediatrics
Authors: Piccolo Claudia , Galluzzo Michele , Trinci Margherita , Ianniello Stefania , Tonerini Michele , Guglielmi Giuseppe , Miele Vittorio
Published: June 2017

A correct interpretation of musculoskeletal imaging studies of children requires an in-depth knowledge of normal skeletal growth and physiologic changes in growing bones. During childhood the growing bones are more prone to acute and chronic injuries because of the imbalance between osseous structures and tendons and ligaments, so physeal injuries are the most commonly encountered types of lesions. This review addresses acute and chronic injuries involving the upper extremities in the pediatric population. These injuries may be subtle to recognize or atypical. The radiologist has to choose the most appropriate technique that can best recognize the problem and establish the correct diagnosis, thus avoiding diagnostic errors and potential delayed complications.
Diagnosis and New Treatment Avenues in Spinal Muscular Atrophy
Authors: Kirschner Janbernd , Pechmann Astrid
Published: June 2017

Spinal muscular atrophy (SMA) is an autosomal-recessive, neuromuscular disorder that is characterized by degeneration of the anterior horn cells of the spinal cord, resulting in muscle atrophy and proximal muscle weakness. SMA is caused by a homozygous deletion in the survival motor neuron 1 (SMN1) gene on chromosome 5q13. The SMN gene region also comprises a centromeric copy containing the SMN2 gene. The severity of the disease correlates with age of onset and SMN2 copy number and varies from a severe muscle weakness with tetraplegia in infants to a mild proximal muscle weakness in ambulant children. Due to lack of a curative treatment, the care of children with SMA consists mostly of a multidisciplinary treatment including respiratory, nutritional, and orthopaedic management. During the past years, there has been a promising approach for the development of drugs intervening the pathophysiology of SMA with the main idea of upregulating the levels of functional SMN protein. Here, we summarize recent studies regarding diagnosis and treatment avenues in SMA.
Metabolic effects of risk alleles inPNPLA3, TM6SF2, GCKRandLYPLAL1inform about heterogeneity of non-alcoholic fatty liver disease
Authors: Sliz Eeva , Sebert Sylvain , Würtz Peter , Kangas Antti J , Soininen Pasi , Lehtimäki Terho , Kähönen Mika , Viikari Jorma , Männikkö Minna , Ala-Korpela Mika , Raitakari Olli T , Kettunen Johannes
Published: June 2017

Fatty liver has been associated with unfavourable metabolic changes in circulation and is considered as a risk factor for cardiometabolic complications such as type 2 diabetes and cardiovascular disease. We aimed to provide insights in fatty liver related metabolic deviations by studying the resemblance between the metabolic profile associated with fatty liver observationally and metabolic profiles of non-alcoholic fatty liver disease (NAFLD) risk increasing genotypes. We determined cross-sectional associations of ultrasound-ascertained fatty liver status with 123 metabolic traits in 1,810 individuals aged 34-49 years from The Cardiovascular Risk in Young Finns Study. The cross-sectional associations were compared with the association profiles of NAFLD risk alleles inPNPLA3,TM6SF2,GCKR, andLYPLAL1with the corresponding metabolic traits obtained from a publicly available genome-wide association study including up to 24,925 European individuals. The analysis revealed substantially different metabolic effects of the risk alleles.PNPLA3rs738409-G, the strongest genetic risk factor to NAFLD, did not associate with metabolic changes.GCKRrs1260326-T resulted in an association profile similar to the observational fatty liver associations. Metabolic effects ofLYPLAL1rs12137855-C were similar, but statistically less robust, to the effects ofGCKRrs1260326-T. In contrast, NAFLD risk alleleTM6SF2rs58542926-T displayed opposite metabolic associations when compared with the observational association pattern.

Conclusion

The divergent effects of the risk alleles on circulating lipids and metabolites underline involvement of several metabolic pathways in NAFLD and suggest that there are pathogenically different subtypes of NAFLD with alternate metabolic consequences. NAFLD risk alleles may have neutral or even cardioprotective effect on circulating lipids and metabolites providing evidence that hepatic lipid accumulation by itself would not necessarily cause the metabolic deviations associated observationally with fatty liver.
Coupling of tactile LFP signals between mouse cortex and olfactory bulb
Authors: Parabucki Ana , Lampl Ilan
Published: June 2017

Local field potentials are an important measure of brain activity and have been used to address various mechanistic and behavioral questions. We revealed a prominent whisker evoked local field potential signal in the olfactory bulb and investigated its physiology. This signal, dependent on barrel cortex activation and highly correlated with its local activity, represented a pure volume conductance signal that was sourced back to the activity in the ventro-lateral orbitofrontal cortex, located a few millimeters away. Thus, we suggest that special care should be taken when acquiring and interpreting LFP data.
Human PRDM9 can bind and activate promoters, and other zinc-finger proteins associate with reduced recombination incis
Authors: Altemose Nicolas , Noor Nudrat , Bitoun Emmanuelle , Tumian Afidalina , Imbeault Michaël , Chapman J. Ross , Aricescu A. Radu , Myers Simon R.
Published: June 2017

Across mammals, PRDM9 binding localizes almost all meiotic recombination hotspots. However, most PRDM9 motif sequence matches are not bound, and most PRDM9-bound loci do not become hotspots. To explore factors that affect binding and subsequent recombination outcomes, we mapped human and chimp PRDM9 binding sites in a human cell line, and measured PRDM9-induced H3K4me3 and gene expression changes. These data revealed varied DNA-binding modalities of PRDM9, and histone modifications that predict binding. At sites where PRDM9 binds, specificcissequence motifs associated with TRIM28 recruitment, and histone modifications, predict whether recombination subsequently occurs. These results implicate the large family of KRAB-ZNF genes in consistent, localized meiotic recombination suppression. PRDM9 affects gene expression for a small number of genes includingCTCFLandVCX, by binding nearby. Finally, we show that PRDM9’s DNA-binding zinc finger domain strongly impacts the formation of multimers, with a pair of highly diverged alleles multimerizing less efficiently.
The weak solvability of the steady problem modelling the flow of a viscous incompressible heat-conductive fluid through the profile cascade
Authors: Neustupa Tomáš
Published: June 2017

Purpose

The paper aims to theoretically study the mathematical model of a steady flow of a heat-conductive incompressible viscous fluid through a spatially periodic plane profile cascade.

Design/methodology/approach

Reduction of the infinite periodical problem to one period. Leray-Schauder fixed point principle was used.

Findings

This study proves the existence of a weak solution for arbitrarily large given data (i.e. the inflow velocity and the acting specific body force).

Practical implications

The author proposed a special boundary condition on the outflow of the domain not only for the velocity and pressure but also for the temperature.

Originality/value

To the author’s knowledge, the problem has not been studied earlier. More detailed overview is given in the paper in the first part.
Getting lost (and found) in supervision: an ethnodrama
Authors: French Amanda , Kendall Alex
Published: June 2017

Purpose

This paper aims to offer an innovative approach to reflecting on research and practice around doctoral study and supervision. In the opening section of the paper, the authors discuss the idea that academic development as a doctoral candidate is concerned with how researchers write themselves into being as certain kinds of researchers, and how, in doing so, they become a character, like their supervisors, in the “figured world” of their research. This process of “becoming” can, the authors argue, be nurtured or hindered by different kinds of supervision practices.

Design/methodology/approach

With regard to the authors’ own experiences of doctoral supervision, the paper explores how their use of post-qualitative practices and methodologies encouraged new forms of intersubjectivity and academic development as their supervisory relationship advanced alongside the thesis itself.

Findings

The authors present the script of an ethnodrama (Saldana, 2111) which they wrote and performed on a number of occasions, as an alternative way of expressing their experiences of being in a relationship as doctoral supervisor and supervisor.

Research limitations/implications

This choice of ethnodrama emerged out of a frustration with what the authors felt were increasingly predictable ways of discussing and reflecting upon the philosophy, content and assessment methods of postgraduate research and supervision across the educational disciplines.

Originality/value

The authors hope that their exploration of the imaginative spaces created through doctoral supervision will encourage other postgraduates and their supervisors to experiment with working creatively across interdisciplinary spaces and creating radical and even risky ways of mediating and sharing postgraduate teaching and learning relationships.
Assessment and Prediction in Homelessness Services and Elsewhere
Authors: O'Flaherty Brendan
Published: June 2017

This article cautions against the naïve use of predictive techniques by homelessness service providers. Prediction is hard and may be impossible. Prediction does not automatically lead to socially optimal assignments. On the other hand, mechanism design, which does not rely on top‐down predictions, can be used to good effect. Moreover, fairness counts as well as optimality—and may be easier to achieve. I use examples from fire service, central banking, police patrol, tax auditing, art, finance, soup kitchens and cadaveric organ allocation.
Self‐reported Mental Health Issues Among Arrestees in the Paris, France Area
Authors: Vidal Camille , Lepresle Aude , Chariot Patrick
Published: June 2017

We studied (May–September 2014) all arrestees who reported mental health issues during the medical examination performed by a forensic physician for the assessment of fitness for detention. Among 4814 arrestees, 420 (9%) reported a current mental health issue. The suspected crimes among arrestees reporting a current mental health issue were more often related to violent behaviors (physical assault, 23% vs. 16%, p < 0.001, sexual assault, 3% vs. 1%, p = 0.01) and less often drug offenses (18% vs. 29%, p < 0.001). Among arrestees reporting mental health issues, 80% reported psychiatric or psychological care, of whom 33% reported previous mental health care. Decisions of unfitness for detention were more frequent among arrestees reporting mental health issues than in other detainees (3% vs. 1%, p < 0.001). The high proportion of patients with interrupted mental health care among those reporting mental disorders suggests that the medical examination during custody could be a significant opportunity to restore psychiatric care.
Relationships between the genes expressed in the mesenteric adipose tissue of beef cattle and feed intake and gain
Authors: Lindholm‐Perry A. K. , Cunningham H. C. , Kuehn L. A. , Vallet J. L. , Keele J. W. , Foote A. P. , Cammack K. M. , Freetly H. C.
Published: June 2017

Mesenteric fat, a depot within the visceral fat, accumulates in cattle during maturation and finishing and may be a potential source of production inefficiency. The aim of this study was to determine whether the genes expressed in the mesenteric fat of steers were associated with body weight gain and feed intake. Sixteen steers chosen by their rank of distance from the bivariate mean for gain and feed intake were used for this study. Mesenteric fat was obtained and evaluated for differences in gene expression. A total of 1831 genes were identified as differentially expressed among steers with variation in feed intake and gain. Many of these genes were involved with metabolic processes such as proteolysis, transcription and translation. In addition, the Gene Ontology annotations including transport and localization were both over‐represented among the differentially expressed genes. Pathway analysis was also performed on the differentially expressed genes. The superoxide radical degradation pathway was identified as over‐represented based on the differential expression of the genes GPX7, SOD2 and TYRP1, suggesting a potential role for oxidative stress or inflammatory pathways among low gain–high intake animals. GPX7 and SOD2 were in lower transcript abundance, and TYRP1 was higher in transcript abundance among the low gain–high feed intake animals. The retinoate biosynthesis pathway was also enriched due to the differential expression of the genes AKR1C3, ALDH8A1, RDH8, RDH13 and SDR9C7. These genes were all more highly expressed in the low gain–high intake animals. The glycerol degradation and granzyme A signaling pathways were both associated with gain. Three glycerol kinase genes and the GZMA gene were differentially expressed among high vs. low gain animals. Mesenteric fat is a metabolically active tissue, and in this study, genes involved in proteolysis, transcription, translation, transport immune function, glycerol degradation and oxidative stress were differentially expressed among beef steers with variation in body weight gain and feed intake.
Structural Zeros and Their Implications With Log‐Linear Bivariate Presmoothing Under the Internal‐Anchor Design
Authors: Kim Hyung Jin , Brennan Robert L. , Lee Won‐Chan
Published: June 2017

In equating, when common items are internal and scoring is conducted in terms of the number of correct items, some pairs of total scores (X) and common‐item scores (V) can never be observed in a bivariate distribution of X and V; these pairs are called structural zeros. This simulation study examines how equating results compare for different approaches to handling structural zeros. The study considers four approaches: the no‐smoothing, unique‐common, total‐common, and adjusted total‐common approaches. This study led to four main findings: (1) the total‐common approach generally had the worst results; (2) for relatively small effect sizes, the unique‐common approach generally had the smallest overall error; (3) for relatively large effect sizes, the adjusted total‐common approach generally had the smallest overall error; and, (4) if sole interest focuses on reducing bias only, the adjusted total‐common approach was generally preferable. These results suggest that, when common items are internal and log‐linear bivariate presmoothing is performed, structural zeros should be maintained, even if there is some loss in the moment preservation property.
Monitoring the Vascular Response and Resistance to Sunitinib in Renal Cell Carcinoma In Vivo with Susceptibility Contrast MRI
Authors: Robinson Simon P. , Boult Jessica K.R. , Vasudev Naveen S. , Reynolds Andrew R.
Published: June 2017

Antiangiogenic therapy is efficacious in metastatic renal cell carcinoma (mRCC). However, the ability of antiangiogenic drugs to delay tumor progression and extend survival is limited, due to either innate or acquired drug resistance. Furthermore, there are currently no validated biomarkers that predict which mRCC patients will benefit from antiangiogenic therapy. Here, we exploit susceptibility contrast MRI (SC-MRI) using intravascular ultrasmall superparamagnetic iron oxide particles to quantify and evaluate tumor fractional blood volume (fBV) as a noninvasive imaging biomarker of response to the antiangiogenic drug sunitinib. We also interrogate the vascular phenotype of RCC xenografts exhibiting acquired resistance to sunitinib. SC-MRI of 786-0 xenografts prior to and 2 weeks after daily treatment with 40 mg/kg sunitinib revealed a 71% (P < 0.01) reduction in fBV in the absence of any change in tumor volume. This response was associated with significantly lower microvessel density (P < 0.01) and lower uptake of the perfusion marker Hoechst 33342 (P < 0.05). The average pretreatment tumor fBV was negatively correlated (R2 = 0.92, P < 0.0001) with sunitinib-induced changes in tumor fBV across the cohort. SC-MRI also revealed suppressed fBV in tumors that acquired resistance to sunitinib. In conclusion, SC-MRI enabled monitoring of the antiangiogenic response of 786-0 RCC xenografts to sunitinib, which revealed that pretreatment tumor fBV was found to be a predictive biomarker of subsequent reduction in tumor blood volume in response to sunitinib, and acquired resistance to sunitinib was not associated with a parallel increase in tumor blood volume. Cancer Res; 77(15); 4127–34. ©2017 AACR.
O efeito do treinamento na percepção do desempenho individual: uma análise baseada nos treinamentos ofertados pelo Instituto Federal do Espírito Santo (IFES)
Authors: Galvao Katia Cristina Cabral Monteiro , Monte-mor Danilo Soares , Tardin Neyla
Published: June 2017

Este artigo investiga se os treinamentos ofertados aos servidores públicos melhoram o seu desempenho no cumprimento de suas atribuições. Para tanto, optou-se por uma Instituição Pública de Ensino, cuja ampliação de suas unidades entre 2008 e 2010 resultou no aumento do quadro de pessoal e na criação da capacitação obrigatória para os novos servidores – Ambientação Institucional.  A partir de um quase experimento, estimou-se o efeito do treinamento no desempenho individual dos servidores que participaram do treinamento, controlando-se por alterações no desempenho de servidores não treinados, e por outras características heterogêneas. Os resultados obtidos sugerem que o treinamento não tem impacto sobre o desempenho individual de servidores público, corroborando com a hipótese de que na ausência de mecanismo de incentivos, o treinamento não impacto desempenho.
Análise comparativa de distintas métricas de risco na composição de um fundo de fundos de investimento imobiliário
Authors: Lovatto Lucas Fernando , Henrique Daniel Christian , Lima Marcus Vinícius Andrade de
Published: June 2017

O propósito central deste estudo é analisar a complementaridade dos resultados de diferentes métricas de risco na composição de um Fundo de FIIs. A partir da revisão de literatura, optou-se pela adoção das métricas de risco variância e Conditional Value-at-Risk, desenvolvidas nos estudos de Markowitz (1952) e Rockafellar e Uryasev (2000, 2002), respectivamente. O estudo abrangeu uma amostra de 30 FIIs listados em bolsa de valores no âmbito da BMF&BOVESPA com retornos diários entre Julho de 2013 e Julho de 2015. Como metodologia, empregou-se modelagem e simulação computacional de carteiras teóricas para minimização do risco não-sistemático, submetendo-as a restrições de acordo com perfis de risco e instruções regulatórias. A principal constatação é de que as diferentes métricas produziram diferentes resultados nos portfólios de menor nível de risco. Observou-se, adicionalmente, que a métrica variância subestimou a probabilidade de perdas extremas.
Wounding the Gods
Authors: Stamatopoulou Zoe
Published: June 2017

In this article, I explore the figure of the mortaltheomachosin archaic Greek hexameter poetry. In particular, I examine how theIliadand the HesiodicAspisconstruct Diomedes and Heracles respectively in their capacity to fight and wound divine opponents. Through a careful study of these two figures, I argue that they are emblematic of the heroic generations they belong to.
Husbands and Fathers
Authors: Browne Randy M. , Burnard Trevor
Published: June 2017

We know relatively little about enslaved men, especially African-born men in British West Indian slave societies, in their roles as fathers and husbands within slave households. A generation of scholarship on gender in slave societies has tended to neglect enslaved men, thus allowing old understandings of enslaved men as not very involved with families drawn from biased planter sources to continue to shape scholarship. This article instead draws on a rich set of records (both quantitative and qualitative) from Berbice in British Guiana between 1819 and 1834 to explore enslaved men’s roles within informal marriages and as husbands and parents. We show not only that enslaved men were active participants in shaping family life within British West Indian slave societies but that they were aided and abetted in achieving some of their familial objectives by a sympathetic plantation regime in which white men favored enslaved men within enslaved households.
Professionals’ Awareness of Sexual Abuse in Late Life: An Exploratory Survey
Authors: Alon Sara , Tuma Niva , Band-Winterstein Tova , Goldblatt Hadass
Published: June 2017

BACKGROUND: The sexual abuse phenomenon is considered taboo. It has been discussed, to date, mainly in relation to children and young women, with insufficient attention to sexual abuse in a late-life context. OBJECTIVES: The aim of this survey was to explore professionals’ awareness of elder sexual abuse (ESA). DESIGN: The survey was conducted among 161 Jewish and Arab professionals from health care and social services, who worked with older adults in Israel. RESULTS: Of the entire sample, 70 professionals (only 43%) reported encountering at least one to three cases of ESA. A total of 98% of the victims were women, and the primary offender was the spouse (75%). In most cases (70%), the victim reported the abuse, which was mainly sexual assault (64%). All participants (100%) noted taking action. CONCLUSION: This exploratory survey indicates that professionals are partially aware of the existence of and the need to address the ESA phenomenon.
Queer Fallout
Authors: Ensor Sarah
Published: June 2017

Taking as its provocation Leo Bersani’s fleeting turn to questions of ecology at the end of his 2002 essay “Sociability and Cruising,” this piece asks what it would mean to use the practice of cruising as an unexpected model for a new ecological ethic, one more deeply attuned to our impersonal intimacies with the human, nonhuman, and elemental strangers that constitute both our environment and ourselves. In order to develop such a model, the essay looks not only to Bersani’s work but also (and primarily) to Samuel R. Delany’s Times Square Red, Times Square Blue, whose attention to the positive fallout of spontaneous cross-class contact, I claim, complicates the proprietary, insular, and paranoid logics prevalent in much popular environmental discourse. Delany’s text, which decenters both intention and identity in its definition of the social, limns the contours of a queer environmentalism predicated less on intentional, direct(ed) investment than on ambient affects, impersonal futures, and nonteleological practices of care.
Licitações públicas sustentáveis: vinculação ou discricionariedade do administrador?
Authors: Mastrodi Josué , Brito Beatriz Duarte Correa de
Published: June 2017

Neste trabalho buscamos analisar, a partir do ordenamento jurídico brasileiro vigente, a possibilidade de se realizarem licitações públicas sustentáveis em todos os níveis da administração pública. Para isso, foram sistematicamente examinadas a Constituição Federal, as Leis nº 8.666/1993 e nº 12.305/2010, bem como o contexto histórico da preocupação mundial com o chamado desenvolvimento sustentável. Assumindo que o princípio da sustentabilidade deve nortear as ações da administração pública, visto que se impõe ao poder público e à coletividade o dever de defender e preservar o meio ambiente ecologicamente equilibrado. A sustentabilidade ambiental deve ser elemento de qualificação de toda e qualquer proposta recebida pela administração em licitações públicas, de modo que a proposta mais vantajosa homologada pelos processos licitatórios somente seja aquela que respeitar as normas de preservação ambiental. In this paper we aim at analyzing, from the current Brazilian law, the possibility of conducting sustainable public bids at all levels of public administration. For this, were systematically examined the Federal Constitution, the Laws nº 8.666/1993 and nº 12.305/2010, as well as the historical context of the global preoccupation with the so-called sustainable development. Assuming that the principle of sustainability should guide the actions of the government, since it imposes upon the government and the society the duty to defend and preserve an ecologically balanced environment, environmental sustainability must be an element of qualification of any proposal received by the administration in public bids, so that the most advantageous proposal approved by the bidding process is only one that meets the standards for preserving the environment.
Do estado social ao estado de risco: a transformação do paradigma da segurança no estado constitucional de direito
Authors: Mauricio Junior Alceu
Published: June 2017

Neste artigo, apresentamos um modelo teórico do estado constitucional de direito que procura fazer frente aos desafios epistemológicos levantados na sociedade de risco. Considerando a crise do modelo do estado social e as transformações provocadas pelos riscos ambientais, sanitários e tecnológicos, vivenciados em uma escala global na sociedade contemporânea, sugerimos que o estado constitucional de direito deve ser compreendido por meio do modelo teórico que denominamos estado de risco. Analisando a transformação do conceito de segurança no estado constitucional de direito, procuramos demonstrar que, mais do que a simples adição de novos fins constitucionais — como a proteção ao meio ambiente e ao consumidor — altera-se a própria fonte de legitimação do Estado. Consideramos que o estado de risco apresenta maior potencial descritivo e normativo do que o estado social, assim como é mais capaz de evidenciar novos desafios democráticos e institucionais levantados na sociedade de riscos. In this Article, we present a new theoretical model of the constitutional rule of law that aims to face the epistemological challenges raised in risk society. Considering the crisis of the social state model and the transformations provoked by environmental, sanitary and technological risks, experienced in a global scale n contemporary society, we suggest that the constitutional rule of law should be understood through the theoretical model we call risk state. Analyzing the transformation of the concept of security in Constitutional rule of law, we seek to demonstrate that, beyond the simple addition of new constitutional goals — such as environmental e consumer protection — the very source of legitimization of the State is changed. We consider that the risk state model has a higher descriptive and normative potential than the social state model, as well as is more capable to evidence democratic and institutional challenges raised in risk society.
RESOURCE-SAVING DESIGNS OF THE COMBINED TAPE BASES
Authors: Крахмальный Тимофей , Krakhmalnyy Timofey , Евтушенко Сергей , Evtushenko Sergey
Published: June 2017

Results of pilot studies of work of the tape bases with a difficult configuration of a sole which provide increase of the bearing ability of the basis are given in article and give the chance of economy of materials.
THE ASSESSMENT OF THE POSSIBILITY OF USING STATIC PENETRATION TESTS OF SOIL MATERIALS FOR CALCULATION OF THE BEARING CAPACITY OF INJECTION PILES
Authors: Полищук Анатолий , Polishchuk Anatoliy , Тарасов Александр , Tarasov Aleksandr
Published: June 2017

The article presents evaluation of the possibility of calculating the bearing capacity of the injection of piles in soft clay soils on materials static penetration with the recommendations of the SP 24.13330.2011- "Pile foundations. Updated version of SNiP 2.02.03-85. Also the the experimental and calculated data are compared
CREATING A SOLID MODEL OF THE SPATIAL STRUCTURE NODE WITH APPLICATION OF SOLIDWORKS COMPLEX
Authors: Царитова Надежда , Tsaritova Nadezhda , Бузало Нина , Buzalo Nina
Published: June 2017

The article outlines the technique of creating the spatial structure node solid model. The model can be translated from SOLIDWORKS complex to numerical simulation
The composite principles of harmonization of modern architecture in the historic environment
Authors: Тумасов Александр , Tumasov Aleksandr
Published: June 2017

Including modern object in the certain spatial environment possessing a certain figurative and historical characteristic, the architect solves a complex problem of the valid and tactful relation to the past and a harmoni-ous combination to it new. Here it is important the cultural and professional potential of the reformer allowing him to choose correct art and style concept. Owning all arsenals of architectural and composite means, he needs to choose what are necessary in a concrete situation.

Allocating art and stylistic aspect of a shaping in the developed historical environment, the artist directly or indirectly uses plastic language of architecture to throw semantic bridges through various styles and eras.

Considers separate (some) examples of successful use of means of harmonization in building of historic centers of such cities as Prague, Vienna. The objects in modern architectural and constructive systems contrasting its conciseness and used materials are perfectly entered in magnificent eclectic building of the XIX century
Determination of the Eextreme Stress in the High-Pressure Drum Power Boilers
Authors: Сербиновский Михаил , Serbinovskiy Mikhail , Курепин Максим , Kurepin Maksim
Published: June 2017

The simulation results of the stress-strain state using the software ANSYS area pipe connection to the steam boiler high pressure drum for pipe connections of various diameters and wall thickness. The areas of extreme local stresses and values of strains caused by the pressure inside the drum and the pipe connection and the temperature gradient in their walls have been determined, stress concentration factors have been calculated. A comparison of the calculated stresses with the stresses obtained by the strain measurement of a physical model of the drum with welded pipe connections has been made. Functions of the extreme stress changes depending on the position of the diametrical section of the pipe connection has been determined. Using the obtained values of stress and concentration coefficients allow to specify the strength calculation of the high-pressure drum and their reliance on low-cycle fatigue
Criteria and Figures of Bankruptcy Predictive Modeling by the Implementation of Business Activities
Authors: Аврашков  , Avrashkov Lyev , Графова  , Grafova Galina , Графов  , Grafov Andrey , Шахватова  , Shakhvatova S.
Published: June 2017

Th e article considers a number of economic-mathematical models on the basis of which probabilities of bankruptcy of the enterprises of various branches can be predicted. Information base for calculation of the fi nancial and economic indicators refl ecting a state and results of economic activity of the enterprise is presented in detail. It is noted that results of calculation of criterion of bankruptcies is for the management of the enterprise of a signal of the early prevention of bankruptcy.
Peculiarities in easy spur cog-wheel shaving
Authors: Клепиков Виктор , Klyepikov Viktor , Черепахин Александр , CHyeryepakhin Alyeksandr
Published: June 2017

A procedure for the definition of female shaver geometrics on the basis of the computation for relative motion velocities of a tool and a blank is offered. On the basis of the theory for the vector direction computation of a relative velocity on a shaver there are developed designs of shavers with sloping and upright chip grooves. Options for chip groove locations for different conditions of shaving are considered.
Science intensive detector for vibration diagnostics based on MEMS and RFID technology
Authors: Мелентьев Василий , Melentiev Vasylyi , Масленников Евгений , Maslennikov Evgeny , Порошин Константин , Poroshin Konstantin , Шибанов Олег , Shibanov Oleg
Published: June 2017

A detector for carrying out vibration diagnostics with MEMS – accelerometer as a vibration detector is presented, and a method for the realization of a vibration detector with a wireless data transfer and activation with the aid of RFID is also under consideration.
INTERCOMPANY STANDARDIZATION OF AUDIT OF FIXED ASSETS
Authors: Клычова  , Klychova Guzaliya , Закирова  , Zakirova Alsu
Published: June 2017

In modern terms, standardization is one of the key factors, that characterize the effective development of audit activities in the Russian Federation and contribute to its adaptation to the requirements of international auditing standards. During the process of standardization of audit activities, a system of documentation is created, that establishes uniform requirements for the audit procedure, the order of formation and presentation of the audit report and the auditor’s report, internal and external control of auditing quality, training of auditors and assessment of their qualifications. The standard sets out rules, general principles, characteristics, intended for permanent and durable usage and affecting various professional activities and their results. The standard is being developed on the basis of mutual consent of the parties and approved by the competent authority. The unified structure of the standard should include: information on general provisions; basic concepts and definitions, that are used in the standard; aims and objectives of the audit of separate accounting object; normative legal acts and sources of information, used in the verification process; methodological approaches to the testing of the internal control system; audit evidence and analysis procedures, used in the verification process; typical errors and irregularities, detected during the audit. Standards are the basis for high-quality audits, introduction into practice of auditing organizations of scientific achievements, define the professional image of the profession, allow users of financial information to communicate with the auditors in the verification process. The application, discussed in an article, internal standards allows to detail professional conduct, because its use is based on the requirements of the federal standards and self-regulatory organizations of auditors. The use of standard in practice improves the quality of audit operations from fixed assets, reduces audit risk, provides an additional control over the work of the audit team.
The challenges of upskilling health care assistants in community nursing
Authors: Pringle Shelley Anne
Published: June 2017

Community care is at the forefront of the National Health Service reforms. Role redistribution from registered nurses to health care assistants is growing. This paper examines the challenges of upskilling community health care assistants to undertake catheterisation for uncomplicated patients in the community. Social constructivist methods facilitated reflective practice. Challenges included fears around delegation, accountability and the responsibilities involved in supporting the development of health care assistants. Recommendations suggest that community health care assistants offer a valuable and much needed contribution to health care delivery and are enthusiastic to upskill in catheterisation. However, reluctance from community registered nurses around delegation delayed the process. Registered nurses will need to address these fears and engage in workforce planning to proactively influence role developments and safe practice. National guidance needs to be structured around clear pathways to support these valued participants in delivering health care.
Contribuições para o ensino das orações principais em construções completivas do português
Authors: Silva Adriana Aparecida da
Published: June 2017

Motivados pela problemática que envolve o ensino de gramática nas salas de aula, apresentamos, neste trabalho, uma proposta didático-pedagógica para o tratamento das orações principais em períodos compostos por subordinação (construções completivas). Investigamos o tratamento dado às orações principais em livros didáticos, partindo-se da premissa de que há uma deficiência na abordagem dessas orações, uma vez que são focalizadas apenas as orações subordinadas (quanto à função sintática que exercem em relação à oração principal). A partir de uma abordagem funcionalista da língua, com base em estudos de Castilho (2012) e Neves (2001), discutimos o estatuto semântico-pragmático dessas orações, propondo uma abordagem mais significativa da sintaxe em sala de aula.
Literatura de cordel e letramento literário: uma sequência básica de leitura para “O Romance do Pavão Misterioso”
Authors: Oliveira Pedrina Carvalho de , Corsi Margarida Da Silveira , Feldman Alba Krishna Topan
Published: June 2017

Este trabalho apresenta os encaminhamentos para a formulação de uma sequência básica de leitura para o “Romance do Pavão Misterioso”, de João Melquíades Ferreira da Silva, e os resultados de sua aplicação em uma turma de oitavo ano do Ensino Fundamental II. Para embasar a elaboração desta proposta de leitura orientada, que visa ao letramento literário do gênero romance de cordel, procedemos à análise do texto conforme as etapas de leitura sugeridas por Michelleti (2000) e Cosson (2014) e rediscutidas Corsi (2015). O diálogo do romance de cordel com outros textos foi trabalhado a partir das considerações de Samoyault (2008) acerca de intertextualidade. Os encaminhamentos para a leitura seguiram as proposições de Cosson (2014) para uma sequência básica de leitura. O material didático produzido objetivou também demonstrar aos alunos que a obra literária se insere numa cadeia comunicativa em que enunciados que a precedem e a sucedem estão intrinsecamente relacionados aos sentidos possíveis atribuídos à leitura, e, por isso, conhecê-los enriquece, ainda mais, a sua interpretação.
Consider these but you won’t
Authors: Piercy Marge
Published: June 2017

Consider the child with curly brown / hair sleeping with her dog in the back / of an old SUV while her parents doze / in scruffy front seats tilted back.…Marge Piercy is the author of many books of poetry, most recently Made in Detroit.Click here to purchase a PDF version of this article at the Monthly Review website.
From the Editor in Chief
Authors: Doğanay Ahmet
Published: June 2017

Değerli bilgi üretici ve tüketicileri,

 

Pegem Eğitim ve Öğretim Dergisi'nin (PEGEGOG) yeni bir sayısıyla daha birlikteyiz. Eğitim bilimleri alanındaki her türlü bilgi üretiminin siz değerli okurlarla paylaşıldığı önemli bir platform olarak PEGEGOG, yenilenerek ve güçlenerek yayın hayatına devam etmektedir. Bu süreçte desteğini esirgemeyen siz değerli yazar, hakem ve okuyucularımıza sonsuz teşekkürlerimi sunuyorum. Sizlerden aldığımız güç ve destekle dergimizi daha ileri noktalara taşıyacağımıza olan inancım tamdır. Derginin web sitesinin yenilenmesi sürecinde sizlere verdiğimiz zahmetten dolayı özür diliyorum. Makalelerin yeniden sisteme yüklenmesi gerekiyordu. Daha önce makalelerini eski sisteme yükleyerek ya da e-posta aracılığıyla gönderen yazarlarımızın büyük çoğunluğu tekrar sisteme yüklediler; ancak bir kısım yazarlarımızdan hala yüklemelerini bekliyoruz. Yazarlarımız makalelerinin son durumunu sistem üzerinden takip edebilirler artık. Bu nedenle tüm işlemlerin sistem üzerinden yürütülmesi gerekiyor. Bu konuda gerekli duyarlılığı göstereceğinize inanıyorum. Bu arada ulusal dizinlerden Arastirmax Bilimsel Yayın İndeksi'nde de taranmaya başlandığımızı memnuniyetle paylaşmak istiyorum. Ayrıca, Ulakbim'de de taranmak için başvurumuzu yaptık ve sonucu bekliyoruz.

 

Dergimizde başlattığımız değişim bu sayı ile de devam ediyor. Kapağın iç sayfasını İngilizce ve Türkçe olarak yeniden düzenledik.  Yine sayfaların dizgisinde de bazı değişiklikler oldu. Makalelerin ilk sayfalarının üstüne derginin logosu, İngilizce ve Türkçe olarak derginin adı, cilt no, sayı ve sayfa numaralarını koyduk. Bu süreçte, değişimlerin oluşturulmasında düşünce ve emek olarak büyük katkılarını gördüğüm dergimizin editör yardımcısı Sayın Serkan DİNÇER'e sonsuz teşekkürlerimi sunuyorum.

 

Değerli yazarlar, bilimsel araştırma sürecinde seçilen problemin önemi ve uygunluğu yanında, o problemin araştırılması için belirlenen yöntem ve sonuçların akademik yazım kurallarına uygun olarak yazılması da oldukça önemli. Bu nedenle web sitemizin "Yazarlar için Bilgi" kısmında ayrıntılı olarak yazar rehberi kısmı oluşturduk. Çalışmalarınızı raporlaştırırken bu rehberi incelemenizi öneriyoruz. Bu rehberde hem etik kurallar hakkında bilgi hem de derginin yazım kuralları hakkında ayrıntılı bilgilere yer verilmiştir. Rehberde ayrıca, makalelerin değerlendirilmesi sürecinde hakemlerimize gönderdiğimiz "Hakem Değerlendirme Formu" da bulunmaktadır. Makalelerinizi dergiye göndermeden önce, bu formdaki ölçütleri dikkate alarak bir öz değerlendirme yapmanızın hakem değerlendirme sürecini olumlu yönde etkileyeceğine inanıyorum.

 

Bu sayıda yeni formatımızla, hakem değerlendirme süreci tamamlanan 6 makaleyi yayımlıyoruz. Türkçe öğretiminden tarih öğretimine, okul öncesi eğitimden öğretmenlerin iletişim ve empatik eğilimlerine ve öğretmen adaylarının tutum ve kaygılarına yönelik eğitim bilimlerinin değişik alanlarından oluşan bu çalışmalardan siz değerli bilgi tüketici ve üreticilerinin yararlanması dileğiyle; tüm hakem, yazar ve okuyucularımıza saygılarımı sunuyorum.

 

Gelecek sayıda buluşmak dileğiyle.
Geography teachers' geography teacher candidates' and high school students' approaches to solve the questions of geography measurement and evaluation
Authors: Balcı Ali
Published: June 2017

This study was prepared to find out views of six geography teachers working in high schools under the Ministry of Education, ten geography teacher candidates who are still undergraduate students at a state university in Istanbul and sixty eight students who study at a high school in Istanbul's Umraniye district about assessment and evaluation of solutions to questions in the field of geography. To this end, a number of questions concerning physical, economic and human geography were gathered from the high school textbook. Experts were asked about their opinions on these questions to ensure the content validity. Ninety percent of the questions were approved by the experts and these questions used with their solutions in a survey form which was formed to gather data. The survey form included open-ended questions fit for purpose. The survey was conducted in 2011-2012 spring term among participants who were chosen using the purposive sampling method. The data that were accumulated at the end of this survey were analyzed using descriptive analysis technique. As a result, it was observed that views of geography teachers geography teacher candidates and high school students about assessment and evaluation are different from each other. The findings interpreted by making suggestions concerning the subject.
Lo animal y lo sagrado según tres poemas de la Enciclopedia de maravillas de Laureano Albán
Authors: Campos López Ronald
Published: June 2017

Este artículo analiza las experiencias del sujeto lírico de la Enciclopedia de maravillas de Laureano Albán, respecto del misterio de lo sagrado a partir de la contemplación de criaturas como el buey, la gaviota y el lobo en los poemas homónimos.