bluuebunny/crossref_metadata_2025 huggingface dataset:
Early-onset Alzheimer’s disease with depression as the first symptom: a case report with literature review
Authors: Liu Meichen , Xie Xueting , Xie Jinghui , Tian Shiyun , Du Xuemei , Feng Hongbo , Zhang Huimin
Published: April 2023

Background

Alzheimer’s disease is a common neurodegenerative disease, and patients with early-onset Alzheimer’s disease (onset age < 65 years) often have atypical symptoms, which are easily misdiagnosed and missed. Multimodality neuroimaging has become an important diagnostic and follow-up method for AD with its non-invasive and quantitative advantages.

Case presentation

We report a case of a 59-year-old female with a diagnosis of depression at the age of 50 after a 46-year-old onset and a 9-year follow-up observation, who developed cognitive dysfunction manifested by memory loss and disorientation at the age of 53, and eventually developed dementia. Combined with neuropsychological scales (MMSE and MOCA scores decreased year by year and finally reached the dementia criteria) and the application of multimodal imaging. MRI showed that the hippocampus atrophied year by year and the cerebral cortex was extensively atrophied. 18F-FDG PET image showed hypometabolism in right parietal lobes, bilateral frontal lobes, bilateral joint parieto-temporal areas, and bilateral posterior cingulate glucose metabolism. The 18F-AV45 PET image showed the diagnosis of early-onset Alzheimer’s disease was confirmed by the presence of Aβ deposits in the cerebral cortex.

Conclusion

Early-onset Alzheimer’s disease, which starts with depression, often has atypical symptoms and is prone to misdiagnosis. The combination of neuropsychological scales and neuroimaging examinations are good screening tools that can better assist in the early diagnosis of Alzheimer’s disease.

Graphical Abstract
Case report: Anorexia nervosa and unspecified restricting-type eating disorder in Jewish ultra-orthodox religious males, leading to severe physical and psychological morbidity
Authors: Laufer Sofia , Herman Estee , Serfaty David , Latzer Yael , Ashkenazi Rachel , Attias Orna , Oren Sinai , Shimomi Meirav , Uziel Moria , Enoch-Levy Adi , Witztum Eliezer , Stein Daniel
Published: April 2023

Background

Young Jewish Ultra-Orthodox women usually show less disturbances in body image and eating in comparison to less religious communities. By contrast, problems with eating are highly unknown and unrecognized in Jewish Ultra-Orthodox males.

Aim

To investigate whether in Ultra-Orthodox males, restricting-type AN (AN-R) with highly obsessional physical activity and unspecified restricting eating disorder (ED) in the context of obsessive–compulsive disorder (OCD) would lead to severe physical and emotional morbidity.

Results

The study included two groups: the first, 3 adolescents with AN-R developing severely increased ritualized obsessional physical activity in addition to restricting eating, requiring inpatient treatment because of severe bradycardia. These youngsters ignored the severity of their obsessional physical activity, continuing with it in hospital despite their grave medical condition. One student began extensive training for triathlon, whereas another student, upon remitting from AN, developed severe muscle dysmorphia. These findings suggest that young Ultra-Orthodox males with AN may develop obsessional physical activity to increase their muscle mass rather than to lose weight Another four Jewish Ultra-Orthodox males developed malnutrition in the context of severe OCD, with no evidence of dieting or body-image disturbances. These individuals developed highly obsessional adherence to different Jewish religious rules, including prolonged praying, asceticism, and overvalued strict adherence to Jewish Kashrut rules of eating, leading in all cases to severe food restriction. They were highly unaware of their severe weight loss and required hospitalization because of severe physical disturbances associated with malnutrition. Moreover, most did not cooperate with their treatment, and their ED-related obsessionality was mostly resistant to psychopharmacotherapy.

Conclusion

Owing to their highly ritualistic rigid way of life, combined with the need for excellency in studying, Jewish Ultra-Orthodox adolescent males with AN might be at a specific risk of developing severe physical disturbances if their illness is associated with highly perfectionistic obsessional physical activity. Second, Jewish Ultra-Orthodox religious males with OCD might be at a specific risk for severe undernutrition, as their rigid relentless observance of Jewish everyday laws might highly interfere with their eating.
Effectiveness of chlamydia Test and Treat strategy in preventing adverse pregnancy outcomes: protocol for a randomized controlled trial
Authors: Liu Lijun , Li Changchang , Sun Xuewan , Yang Bin , Zheng Heping , Li Meng , Huang Shujie , Wang Cheng , Tang Weiming
Published: April 2023

Introduction

Chlamydia trachomatis is one of the most common bacterial sexually transmitted infections worldwide, and is associated with an increased risk of adverse pregnancy outcomes. However, whether providing chlamydia screening and treatment during the first trimester of pregnancy could reduce adverse pregnancy outcomes is still not clear. This study reports a randomized controlled trial (RCT) protocol to evaluate the effectiveness of chlamydia Test and Treat during early pregnancy in preventing adverse pregnancy outcomes in China.

Methods and analysis

This trial is a multi-center two-arm RCT targeting 7,500 pregnant women in early pregnancy (6–20 weeks). The inclusion criteria included: 18–39 years old, on their first antenatal visit, in the first trimester, and plan to deliver in the study cities. Following a block randomization procedure, every block of twenty women will be randomly assigned in a 1:1 ratio into two arms: (1) a Test and Treat arm in which women receive free chlamydia testing immediately after enrollment and people tested as chlamydia positive will receive standardized treatment and partner treatment; (2) a control arm in which women receive regular prenatal care without receiving testing during the pregnancy period, but collect urine samples and test them after delivery or indicating a chlamydia-related complication during pregnancy happens. The primary outcome is a composite of eight adverse events rate at delivery between two arms, including stillbirth, infant death, spontaneous abortion, preterm labor, low birth weight, premature rupture of membranes, postpartum endometritis, and ectopic pregnancy. Secondary outcomes include the cost-effectiveness of the intervention, the proportion of people tested with chlamydia infection, the proportion of tested-positive patients that received treatment, and the proportion of people who were cured 1 month after the treatment initiation. Urine specimens will be collected and tested for chlamydia by using Nucleic Acid Amplification Test. Data will be analyzed according to the intention-to-treat principle.

Discussion

This trial will test the hypothesis that early testing and treating of chlamydia can reduce the risk for adverse pregnancy outcomes and may help in developing chlamydia screening guidelines in China and other countries with a similar prevalence of chlamydia infection.

Trial registration

Chinese Clinical Trials Registry, ChiCTR2000031549. Registered on April 4, 2020.
Evaluating the effectiveness of lockdowns and restrictions during SARS-CoV-2 variant waves in the Canadian province of Nova Scotia
Authors: Sganzerla Martinez Gustavo , Hewins Benjamin , LeBlanc Jason J. , Ndishimye Pacifique , Toloue Ostadgavahi Ali , Kelvin David J.
Published: April 2023

Introduction

After the initial onset of the SARS-CoV-2 pandemic, the government of Canada and provincial health authorities imposed restrictive policies to limit virus transmission and mitigate disease burden. In this study, the pandemic implications in the Canadian province of Nova Scotia (NS) were evaluated as a function of the movement of people and governmental restrictions during successive SARS-CoV-2 variant waves (i.e., Alpha through Omicron).

Methods

Publicly available data obtained from community mobility reports (Google), the Bank of Canada Stringency Index, the “COVID-19 Tracker” service, including cases, hospitalizations, deaths, and vaccines, population mobility trends, and governmental response data were used to relate the effectiveness of policies in controlling movement and containing multiple waves of SARS-CoV-2.

Results

Our results indicate that the SARS-CoV-2 pandemic inflicted low burden in NS in the initial 2 years of the pandemic. In this period, we identified reduced mobility patterns in the population. We also observed a negative correlation between public transport (−0.78), workplace (−0.69), retail and recreation (−0.68) and governmental restrictions, indicating a tight governmental control of these movement patterns. During the initial 2 years, governmental restrictions were high and the movement of people low, characterizing a ‘seek-and-destroy’ approach. Following this phase, the highly transmissible Omicron (B.1.1.529) variant began circulating in NS at the end of the second year, leading to increased cases, hospitalizations, and deaths. During this Omicron period, unsustainable governmental restrictions and waning public adherence led to increased population mobility, despite increased transmissibility (26.41-fold increase) and lethality (9.62-fold increase) of the novel variant.

Discussion

These findings suggest that the low initial burden caused by the SARS-CoV-2 pandemic was likely a result of enhanced restrictions to contain the movement of people and consequently, the spread of the disease. Easing public health restrictions (as measured by a decline in the BOC index) during periods of high transmissibility of circulating COVID-19 variants contributed to community spread, despite high levels of immunization in NS.
The relationship between use of complementary and alternative medicine and health literacy in chronically ill outpatient cases: a cross-sectional study in southeastern Iran
Authors: Dehghan Mahlagha , Rad Mahla Mohebi , Lari Leyla Ahmadi , Ghorbani-nejad Behnam , Mohebi-Rad Milad
Published: April 2023

Background

Chronically ill outpatient cases use a variety of complementary and alternative medicines due to their diseases and therapeutic complications. Chronic condition, quality of life, and health literacy all affect the use of complementary medicine among chronically ill outpatient cases. Health literacy helps patients make fully informed decisions about the use of complementary and alternative medicine. This study aimed to investigate the relationship between complementary and alternative medicine and health literacy in chronically ill outpatient cases.

Method

This cross-sectional analytical-descriptive study was conducted on 400 chronically ill outpatient cases referred to medical centers affiliated to Kerman University of Medical Sciences. Convenience sampling was used. Research tools included the complementary and alternative medicine questionnaire and the health literacy questionnaire. SPSS25 was used to analyze data.

Results

The mean use of complementary and alternative medicine in a recent year was 16.75 ± 7.89, which was lower than the mid-point of the questionnaire (84). Prayer, medicinal plants, vitamin supplements, music therapy, and art therapy were the mostly used complementary and alternative medicine methods. The most common reasons for using complementary medicine were to reduce physical complications and improve anxiety and stress. The mean satisfaction with the use of complementary and alternative medicine was 34.96 ± 6.69. The mean health literacy score was 67.13 ± 19.90. Decision-making and the use of health information had the highest mean score among the dimensions of health literacy, whereas reading skills received the lowest mean score. We found a significant and direct relationship between the use of complementary and alternative medicine, health literacy, and all its dimensions.

Conclusion

The study results showed that health literacy predicted the use of complementary and alternative medicine. Health education and promotion programs may be useful for improvement of health literacy in the community.
Legalizing illegalities? Land titling and land tenure security in informal settlements
Authors: Bwalya Umar Bridget , Kapembwa Julius , Kaluma Ketiwe , Siloka Lawrence , Mukwena Dipuo
Published: April 2023

This study investigated how land rights formalization had affected land tenure security among landowners in two informal settlements of Lusaka and Chongwe districts, Zambia. It explored how social norms on land inheritance, decision making over land, marital trust and land related conflicts had been affected by the changed nature of land rights. Data was collected through a questionnaire survey of all the 302 households that had obtained title deeds at the time of the survey, two 3-in-1 focus group discussions and four key informant interviews. Results suggest that land tenure security is now a reality for residents that hitherto lived under constant threat of eviction. Landowners have benefitted from the formalization initiative through land laws and local norms that allow equitable access to land. Land rights formalization has curtailed land rights for secondary claimants such as extended family members, in preference for man, spouse and biological children. A sense of ownership undisputedly increased for men and women in the two study sites. About 50% of the respondents in both study sites indicated that formalization of land rights had not resulted in family conflicts. At least one-third from both sites reported an increase in love and trust between spouses after land rights formalization. About half of the respondents reported that no change in decision-making authority had occurred for men while 42% reported an increase. Formalizing land rights in informal settlements has entailed legalizing illegalities as regulations on plot boundaries are set aside by the state to achieve its aspirations of providing land tenure security to poor urbanites who would not otherwise have recourse to legal or regularized land. We recommend that caution be taken in promoting what is unarguably a pro-poor initiative to ensure that such initiatives should not incentivize future land encroachments.
Building agroecological traction: Engaging discourse, the imaginary, and critical praxis for food system transformation
Authors: Kelinsky-Jones Lia R. , Niewolny Kim L. , Stephenson Max O.
Published: April 2023

Shifting the current food system toward a more sustainable and equitable model requires an alternative imaginary. Agroecology represents such an approach, but despite the construct’s promise, policy and academic communities alike continue to maintain the current system. We contend that shifting away from the existing, dominant food system requires researchers to engage stakeholders with discourses that give meaning to an agroecological imaginary. We provide a methodological case study for how interested analysts may build agroecological traction through critical praxis. We advance our argument theoretically, methodologically, and empirically. Theoretically, we draw on scholarship arguing that food system transformation requires a discursive imaginary. Methodologically, we outline how Critical Discourse Analysis (CDA) as both a theoretical and methodological framework, illuminates the discursive power that shapes the future of food. We first used CDA to analyze United States Agency for International Development (USAID) policy, and subsequently presented those results to focus groups comprised of USAID-funded university-based research-practitioners. Empirically, we suggest that our methodology represents one possible mechanism or strategy to encourage the dialogue necessary to secure a new critical food system praxis. We conclude by offering recommendations for future inquiry.
Expanding food democracy: a perspective from the United States
Authors: Anderson Molly D.
Published: April 2023

Food democracy can be a tool to combat capitalist hegemony in the food system and increase citizen’s knowledge about alternatives to obtaining food from concentrated food businesses. But for food democracy to further democratic goals, it needs to help create these alternatives as transformational spaces, seek genuine inclusion of underprivileged people in food system governance, and ensure that public forums for deliberation about the food system are active and respected by public institutions.
Development of attractants and repellents for Tuta absoluta based on plant volatiles from tomato and eggplant
Authors: Chen Tingting , Chen Limin , Wang Jinchao , Cheng Jianghui , Yi Songwang , Hafeez Muhammad , Zhou Shuxing , Li Yuanxi , Li Xiaowei , Lu Yaobin
Published: April 2023

Introduction

Tuta absoluta is currently considered one of the most devastating invasive pests of solanaceous plants worldwide, causing severe damage to the tomato industry. Insects use volatile organic compounds (VOCs) to locate host plant for feeding and oviposition. Those VOCs could be developed as lures for pest monitoring and control.

Methods

In this study, the differentially accumulated VOCs between the preferred host (tomato) and non-preferred host (eggplant) were analyzed by GC–MS method, and their roles on female T. absoluta host selection and egg laying behaviors were investigated using electroantennography (EAG), olfactometer and cage experiments.

Results

A total of 39 differentially accumulated VOCs were identified in tomato and eggplant. Strong EAG signals were obtained in 9 VOCs, including 5 VOCs highly accumulated in tomato and 4 VOCs highly accumulated in eggplant. Further olfactometer bioassays showed that 4 compounds (1-nonanol, ethyl heptanoate, ethyl octanoate and o-nitrophenol) were attractive to T. absoluta females, while 5 compounds (2-phenylethanol, 2-pentylfuran, trans,trans-2,4-nonadienal, 2-ethyl-5-methylpyrazine and trans-2-nonenal) were repellent, indicating that VOCs from host plants play important roles in host plant preferences. The attractive activities of 1-nonanol and ethyl octanoate, as well as the repellent activities of trans,trans-2,4-nonadienal and trans-2-nonenal, were further confirmed in cage experiments.

Discussion

In this study, two attractants and two repellents for T. absoluta were developed from plant released VOCs. Our results could be useful to enhance the development of eco-friendly and sustainable pest management strategies for T. absoluta.
Comparisons of oblique lumbar interbody fusion and transforaminal lumbar interbody fusion for degenerative spondylolisthesis: a prospective cohort study with a 2-year follow-up
Authors: Wu Jingye , Ao Jintao , Xu Zhongning , Li Guanqing , Ge Tenghui , Wang Yongqing , Tao Xiaohui , Tian Wei , Sun Yuqing
Published: April 2023

Objective

This study aimed to compare the clinical outcomes between oblique (OLIF) and transforaminal lumbar interbody fusion (TLIF) for patients with degenerative spondylolisthesis during a 2-year follow-up.

Methods

Patients with symptomatic degenerative spondylolisthesis who underwent OLIF (OLIF group) or TLIF (TLIF group) were prospectively enrolled in the authors’ hospital and followed up for 2 years. The primary outcomes were treatment effects [changes in visual analog score (VAS) and Oswestry disability index (ODI) from baseline] at 2 years after surgery; these were compared between two groups. Patient characteristics, radiographic parameters, fusion status, and complication rates were also compared.

Results

In total, 45 patients were eligible for the OLIF group and 47 patients for the TLIF group. The rates of follow-up were 89% and 87% at 2 years, respectively. The comparisons of primary outcomes demonstrated no different changes in VAS-leg (OLIF, 3.4 vs. TLIF, 2.7), VAS-back (OLIF, 2.5 vs. TLIF, 2.1), and ODI (OLIF, 26.8 vs. TLIF, 30). The fusion rates were 86.1% in the TLIF group and 92.5% in the OLIF group at 2 years (P = 0.365). The OLIF group had less estimated blood loss (median, 200 ml) than the TLIF group (median, 300 ml) (P < 0.001). Greater restoration of disc height was obtained by OLIF (mean, 4.6 mm) than the TLIF group (mean, 1.3 mm) in the early postoperative period (P < 0.001). The subsidence rate was lower in the OLIF group than that in the TLIF group (17.5% vs. 38.9%, P = 0.037). The rates of total problematic complications were not different between the two groups (OLIF, 14.6% vs. TLIF, 26.2%, P = 0.192).

Conclusion

OLIF did not show better clinical outcomes than TLIF for degenerative spondylolisthesis, except for lesser blood loss, greater disc height restoration, and lower subsidence rate.
Mycobacterium bovis naturally infected calves present a higher bacterial load and proinflammatory response than adult cattle
Authors: Carrisoza-Urbina Jacobo , Bedolla-Alva Mario A. , Hernández-Pando Rogelio , López-Macías Constantino , Huerta-Yepez Sara , Baay-Guzmán Guillermina , Juárez-Ramírez Mireya , Gutiérrez-Pabello José A.
Published: April 2023

Granulomas are characteristic bovine tuberculosis lesions; studying this structure has improved our understanding of tuberculosis pathogenesis. However, the immune response that develops in granulomas of young cattle naturally infected with Mycobacterium bovis (M. bovis) has not been fully studied. Our previous work described an atypical pattern in granulomatous lesions of cattle younger than 4 months (calves) naturally infected previously M. bovis that did not correspond to the histological classification previously proposed. Histologically, granulomas from calves lack a connective tissue capsule and have fewer multinucleated giant cells (MGCs) and more acid-fast bacilli (AFB) than the classic tuberculosis lesions found in cattle older than 1 year (adults); this suggests a deficient immune response against M. bovis infection in young animals. Therefore, we used IHC and digital pathology analysis to characterize the in situ immune response of granulomas from young and adult cattle. The immunolabeling quantification showed that granulomas from calves had more mycobacteria, CD3+ cells, IFN-γ, TNF-α, and inducible nitric oxide synthase (iNOS) than those of adult cattle. Furthermore, calf granulomas showed lower immunolabeling of MAC387+, CD79+, and WC1+ cells without connective tissue surrounding the lesion and were associated with less vimentin, Alpha Smooth Muscle Actin (α-SMA), and TGF-β compared with granulomas from adult cattle. Our results suggest that the immune responses in granulomas of cattle naturally infected with M. bovis may be age dependent. This implies that an exacerbated proinflammatory response may be associated with active tuberculosis, producing more necrosis and a lower microbicidal capacity in the granulomas of calves naturally infected with M. bovis.
Effects of forage type on the rumen microbiota, growth performance, carcass traits, and meat quality in fattening goats
Authors: Wu Zhou-lin , Yang Xue , Zhang Jiamin , Wang Wei , Liu Dayu , Hou Bo , Bai Ting , Zhang Rui , Zhang Yin , Liu Hanyang , Hu Hongwen , Xia Yunhong
Published: April 2023

Forages fed to goats influence ruminal microbiota, and further contribute to affect growth performance, meat quality and its nutritional composition. Our objective for current study was to investigate the effects of different forages on growth performance, carcass traits, meat nutritional composition, rumen microflora, and the relationships between key bacteria and amino acids and fatty acids in the longissimus dorsi and semimembranosus muscles of goats. Boer crossbred goats were separately fed commercial concentrate diet supplemented with Hemarthria altissima (HA), Pennisetum sinese (PS), or forage maize (FG), and then slaughtered 90 days after the beginning of the experiment. Growth performances did not vary but carcass traits of dressing percentage, semi-eviscerated slaughter percentage, and eviscerated slaughter percentage displayed significant difference with the treatment studied. Meats from goats fed forage maize, especially semimembranosus muscles are rich in essential amino acids, as well as an increase in the amount of beneficial fatty acids. Our 16S rRNA gene sequencing results showed that the Firmicutes, Bacteroidetes, and Proteobacteria were the most dominant phyla in all groups but different in relative abundance. Further, the taxonomic analysis and linear discriminant analysis effect size (LEfSe) identified the specific taxa that were differentially represented among three forage treatments. The spearman’s correlation analysis showed that rumen microbiota was significantly associated with the goat meat nutritional composition, and more significant positive correlations were identified in semimembranosus muscles when compared with longissimus dorsi muscles. More specifically, the lipid metabolism-related bacteria Rikenellaceae_RC9_gut_group showed positively correlated with meat amino acid profile, while genera Oscillospiraceae_UCG-005 were positively correlated with fatty acid composition. These bacteria genera might have the potential to improve nutritional value and meat quality. Collectively, our results showed that different forages alter the carcass traits, meat nutritional composition, and rumen microflora in fattening goats, and forage maize induced an improvement in its nutritional value.
Optimum Support Policy Component for the Development of Agricultural Production: Potato Producer
Authors: Taşcıoğlu Yavuz , Gül Mevlüt , Akpınar Metin Göksel , Karlı Bahri , Kadakoğlu Bektaş , Şirikçi Bekir Sıtkı , Acar Musa , Yılmaz Hilal
Published: April 2023

The present study aimed to determine the optimum policy component in an example of potato cultivation development based on the principle of the efficient use of scarce resources and maximizing the benefit of the producer. Agricultural support policies are commonly implemented by adopting a top-down approach. Regarding benefit maximization at the target group level, policies for agricultural products should be determined with a bottom-up approach. In this manner, in the present study, potato producers were determined to be the target group. Therefore, this study investigated the policy component that provides the highest benefit in line with the demands, expectations, and tendencies of the target group. The micro-data obtained from the potato-growing enterprises operating in provinces where potato cultivation was intensively carried out within the scope of Turkey constituted the research data. A face-to-face survey technique was used as the method for collecting the producer data. Simple descriptive statistics and one of the multivariate analysis techniques, conjoint analysis, were applied in the analysis and evaluation of the data. The optimum policy component setup was determined to be “Price and Payment Support: Above Market Price and 2 months term, Support Area and Amount: to production, 25.47 USD/da (23.04 EUR/da), time of announcement for the supports: pre-planting, and producer’s declaration: I do (I declare)” for the potato product. Accordingly, the necessity of a bottom-up approach in the planning and implementation of an agricultural support policy in Turkey is explained based on the results obtained. Therefore, it is considered necessary and beneficial to measure the level of producer benefits on the focus of applications that encourage potato production.
Calibration of Contact Parameters for Particulate Materials in Residual Film Mixture after Sieving Based on EDEM
Authors: Zhou Pengfei , Li Yaping , Liang Rongqing , Zhang Bingcheng , Kan Za
Published: April 2023

In this study, to obtain the contact parameters of particulate materials accurately and quickly in residual film mixture after sieving, the contact parameters of particulate materials were calibrated via a physical test and simulation test. By using the self-made dynamic angle of a repose measurement test bench, the dynamic angle of repose of the particulate materials was measured at 41.32°, and the standard deviation was 1.33°. A discrete element simulation of the dynamic angle of the repose test was performed via an EDEM screening experiment design through a simulation of a combination of different parameters, with the dynamic angle of repose as the response value. Through simulation experiments, three significant influencing factors, as well as the level range of each factor, were confirmed. By using the response surface experiment, a mathematical model of the dynamic angle of repose and the three most influential parameters was created. The analysis of variance showed that the determination coefficient R2 and the correction determination coefficient R2adj were 0.9824 and 0.9598, respectively. The model had a good fit. The variable coefficient was 2.06% and the lack of fit was non-significant, which showed that the regression model was very significant, and the dynamic angle of repose could be predicted according to the model. By solving the optimization for the mathematical model, the optimal combination of parameters with three important influencing factors were obtained. The results showed that the coefficient of the static friction between soil and soil was 0.38, the coefficient of the rolling friction between soil and soil was 0.08, and the coefficient of the static friction between cotton residue and cotton residue was 0.33. The relative error of the dynamic angle of repose between the simulation with the optimal parameter combination and the physical test value was 2.64%. The results could provide a reference for the calibration of the discrete element model parameters of other agricultural particulate material, as well as provide a theoretical basis for the design of related collecting and conveying machinery.
The Effect of Faecal Sludge Biochar on the Growth and Yield of Tomato (Solanum lycopersicum L.) Cultivar Micro-Tom
Authors: Nicholas H. Larissa , Devine Aisling , Robertson Iain , Mabbett Ian
Published: April 2023

Full-scale pyrolysis of faecal sludge in developing nations is an emerging technology for the complete removal of pathogens and the concurrent creation of biochar, a soil amendment shown to enhance crop productivity. Currently there is little information on the effects of faecal sludge biochar on soil and crop yield. Faecal sludge biochar was applied to an acidic, sandy soil to assess its effects on plant growth and yield in Micro-Tom, a model cultivar of tomato (Solanum lycopersicum L.). We examined four soil application treatments: a control soil, fertilizer treatment, biochar treatment, and a combined biochar and fertilizer treatment. The combined treatment of biochar and fertilizer together produced a tomato yield 2980% greater than the tomato yield from control soil, whereas biochar on its own increased the yield by 1060%. There was no significant difference in plant height between the combined biochar and fertilizer application and biochar on its own; however, both treatments significantly increased plant height compared to control soil. Below ground biomass showed a similar pattern, with no significant difference between biochar alone and combined biochar and fertilizer treatments, and both treatments resulted in significantly increased below ground biomass compared to control soil. The combined biochar and fertilizer treatment resulted in significantly lower water runoff than all other treatments. These findings have great potential implications for increasing food security and the creation of more sustainable agricultural practices, especially in developing regions.
Antimicrobial and Antibiofilm Properties of Latvian Honey against Causative Agents of Wound Infections
Authors: Skadiņš Ingus , Labsvārds Krišs Dāvids , Grava Andra , Amirian Jhaleh , Tomsone Laura Elīna , Ruško Jānis , Viksna Arturs , Bandere Dace , Brangule Agnese
Published: April 2023

Honey is widely used in traditional medicine and modern wound healing biomaterial research as a broad-spectrum antimicrobial, anti-inflammatory and antioxidant agent. The study’s objectives were to evaluate the antibacterial activity and polyphenolic profiles of 40 monofloral honey samples collected from beekeepers in the territory of Latvia. The antimicrobial and antifungal activity of Latvian honey samples were compared with commercial Manuka honey and the honey analogue sugar solutions–carbohydrate mixture and tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, clinical isolates Extended-Spectrum Beta-Lactamases produced Escherichia coli, Methicillin-resistant Staphylococcus aureus and Candida albicans. Antimicrobial activity was evaluated with the well-diffusion method (80% honey solution w/v) and microdilution method. The honey samples with the highest antimicrobial potential were tested to prevent biofilm development and activity against a preformed biofilm. The principal component analysis of the antimicrobial properties of honey samples vs. polyphenolic profile was performed. Eleven honey samples exhibited antibacterial activity to all investigated bacteria. The antibacterial effect of the samples was most significant on the Gram-positive bacteria compared to the studied Gram-negative bacteria. Latvian honey presents promising potential for use in wound healing biomaterials, opening the possibility of achieving long-term antibacterial effects.
Insights into the Role of Oxidative Stress and Reactive Oxygen Species in Parasitic Diseases
Authors: Ankri Serge
Published: April 2023

Parasitic infections remain a significant public health challenge in many parts of the world, especially in developing countries [...]
Peroxiredoxin 2: An Important Element of the Antioxidant Defense of the Erythrocyte
Authors: Sadowska-Bartosz Izabela , Bartosz Grzegorz
Published: April 2023

Peroxiredoxin 2 (Prdx2) is the third most abundant erythrocyte protein. It was known previously as calpromotin since its binding to the membrane stimulates the calcium-dependent potassium channel. Prdx2 is present mostly in cytosol in the form of non-covalent dimers but may associate into doughnut-like decamers and other oligomers. Prdx2 reacts rapidly with hydrogen peroxide (k > 107 M−1 s−1). It is the main erythrocyte antioxidant that removes hydrogen peroxide formed endogenously by hemoglobin autoxidation. Prdx2 also reduces other peroxides including lipid, urate, amino acid, and protein hydroperoxides and peroxynitrite. Oxidized Prdx2 can be reduced at the expense of thioredoxin but also of other thiols, especially glutathione. Further reactions of Prdx2 with oxidants lead to hyperoxidation (formation of sulfinyl or sulfonyl derivatives of the peroxidative cysteine). The sulfinyl derivative can be reduced by sulfiredoxin. Circadian oscillations in the level of hyperoxidation of erythrocyte Prdx2 were reported. The protein can be subject to post-translational modifications; some of them, such as phosphorylation, nitration, and acetylation, increase its activity. Prdx2 can also act as a chaperone for hemoglobin and erythrocyte membrane proteins, especially during the maturation of erythrocyte precursors. The extent of Prdx2 oxidation is increased in various diseases and can be an index of oxidative stress.
Spontaneous Osteogenic Potential of Periosteum after Segmental Mandibulectomy in Patients with Medication-Related Osteonecrosis of the Jaw (MRONJ): A Retrospective Study of 14 Cases
Authors: Kwon Youngmin , Fang Yi-Qin , Lee Seungjin , Lee Chunui
Published: April 2023

Medication-related osteonecrosis of the jaw (MRONJ) has chiefly involved patients receiving medications for the treatment of bone-related malignancies. The surgical methods are now cautiously recommended as the treatment option for MRONJ. The purpose of this retrospective study was to report new bone formation and examine possible factors influencing spontaneous bony bridge formation by using an R-plate for reconstruction without any graft material after segmental mandibulectomy in patients with MRONJ. A cohort of 54 patients who underwent mandibulectomy between 2017 and 2022 by a single operator were included. Of them, 14 MRONJ patients (12 females and 2 males) were selected based on the inclusion criteria. Data on new bone formation, bony bridge formation, R-plate fracture, patient age, and type and duration of medication were collected. The mean age of the patients was 74.8 ± 9.3 years. All patients showed new bone formation, and 71.4% showed bony bridge formation within a year after surgery. The older the patient, the lower was the tendency for bony bridge formation in the defect (p = 0.035). Statistical analysis was performed using Fisher’s exact test. Preservation of the periosteum might be one of the most important contributing factors to new bone formation, serving as an optimal treatment option for reconstruction after segmental mandibulectomy in patients with MRONJ.
An Intrusion Detection System Using BoT-IoT
Authors: Alosaimi Shema , Almutairi Saad M.
Published: April 2023

The rapid growth of the Internet of Things (IoT) has led to an increased automation and interconnectivity of devices without requiring user intervention, thereby enhancing the quality of our lives. However, the security of IoT devices is a significant concern as they are vulnerable to cyber-attacks, which can cause severe damage if not detected and resolved in time. To address this challenge, this study proposes a novel approach using a combination of deep learning and three-level algorithms to detect attacks in IoT networks quickly and accurately. The Bot-IoT dataset is used to evaluate the proposed approach, and the results show significant improvements in detection performance compared to existing methods. The proposed approach can also be extended to enhance the security of other IoT applications, making it a promising contribution to the field of IoT security.
Transmission Reduction for UV and IR Radiation with Dyed Lyocell Knitted Textiles
Authors: Klinkhammer Kristina , Weskott Phillip , Ratovo Karin , Krieg Marcus , Bendt Ellen , Mahltig Boris
Published: April 2023

Sunlight is essential for humans. However, sunlight can be the source of several disadvantageous effects and illnesses, e.g., skin aging, sunburn, and skin cancer. Textiles with functional protective effects can counteract these problems. In the current research, knitted fabrics were produced from Lyocell yarns spin-doped with the inorganic UV absorber titanium dioxide TiO2. Lyocell yarns without TiO2 were used as reference materials. The produced knitted fabrics were dyed with different dyestuffs to improve the protective properties against UV light and infrared light. The protective properties are determined by optical spectroscopy in an arrangement of diffusive transmission. With the two dyestuffs Drimaren Yellow HF-CD and Solophenyl Bordeaux 3BLE, dyes were determined which complete UV protection and additionally reduce transmission in the near-IR range (700 nm to 1000 nm). TiO2 in the fibers enhanced this effect. In the UV range (280 nm to 400 nm), the transmission was almost zero with both dyes. Overall, the Lyocell samples containing TiO2 exhibit less sensitivity to abrasion and a UV protective effect after washing can be still determined. The weight loss after the abrasion test for these samples is quite low with only around 8.5 wt-% (10,000 rubbing cycles in the Martindale device). It is concluded that the right choice of dye can improve the protective effect of textiles against various types of radiation. Lyocell fiber-based textiles are suitable for the production of summer clothing due to their good moisture management. Compared to other radiation protective materials based on coating application, the presented solution is advantageous, because the textile properties of the realized products are still present. For this, a direct transfer to clothing application and use in apparel is easily possible. This study can be seen as the first proof-of-concept for the future development of light-protective clothing products.
Ricci Curvature on Birth-Death Processes
Authors: Hua Bobo , Münch Florentin
Published: April 2023

In this paper, we study curvature dimension conditions on birth-death processes which correspond to linear graphs, i.e., weighted graphs supported on the infinite line or the half line. We give a combinatorial characterization of Bakry and Émery’s CD(K,n) condition for linear graphs and prove the triviality of edge weights for every linear graph supported on the infinite line Z with non-negative curvature. Moreover, we show that linear graphs with curvature decaying not faster than −R2 are stochastically complete. We deduce a type of Bishop-Gromov comparison theorem for normalized linear graphs. For normalized linear graphs with non-negative curvature, we obtain the volume doubling property and the Poincaré inequality, which yield Gaussian heat kernel estimates and parabolic Harnack inequality by Delmotte’s result. As applications, we generalize the volume growth and stochastic completeness properties to weakly spherically symmetric graphs. Furthermore, we give examples of infinite graphs with a positive lower curvature bound.
Advanced Metal-Organic Frameworks Based on Anthraquinone-2,3-Dicarboxylate Ligands as Cathode for Lithium-Ion Batteries
Authors: Lai Minjie , Zhang Dongying , Chen Fenghua , Lin Xiaoying , Qiu Ankun , Lei Chenxi , Liang Jiaying , Liang Junfeng , Li Jianhui , Wang Qunfang , Zeng Ronghua
Published: April 2023

Quinone organic materials are promising electrodes for the next lithium-ion batteries (LIBs) owing to their versatile molecular designs, high theoretical capacity, flexibility, sustainability, and environmental friendliness. However, quinone organic electrode materials can easily dissolve in organic electrolytes during the cycling process, which leads to the decay of capacity and poor cycling stability. Here, two metal-organic frames (MOFs), one-dimensional (1D) linear structural anthraquinone-2,3-dicarboxylate zinc coordination polymer (ZnAQDC) and two-dimensional (2D) structural anthraquinone-2,3-dicarboxylate manganese coordination polymer (MnAQDC), are synthesized by using anthraquinone 2,3-dicarboxylic acid, zinc acetate, and manganese acetate in a simple hydrothermal reaction. The formed 1D and 2D structures facilitate the insertion and extraction of lithium ions in and from carbonyl groups of anthraquinone. When MnAQDC is used as cathodes for LIBs, MnAQDC electrodes show an initial discharge capacity of ~63 mAh g−1 at 50 mA g−1. After 200 cycles, the MnAQDC electrode still maintains the specific capacity of ~45 mA h g−1, which exhibits good cycle stability. the ZnAQDC electrode displays a initial discharge capacity of ~85 mA h g−1 at 50 mA g−1, and retains the specific capacity of ~40 mA h g−1 after 200 cycles, showing moderate cyclic performance. The lithium-inserted mechanism shows that lithium ions are inserted and extracted in and from the carbonyl groups, and the valences of the Zn and Mn ions in the two MOFs do not change, and coordination metals do not contribute capacities for the two MOFs electrodes. The strategy of designing and synthesizing MOFs with 1D and 2D structures provides guidance for suppressing the dissolution and improving the electrochemical performance of quinone electrode materials.
Comparing the Performance of CMCC-BioClimInd and WorldClim Datasets in Predicting Global Invasive Plant Distributions
Authors: Zhang Feixue , Wang Chunjing , Zhang Chunhui , Wan Jizhong
Published: April 2023

Species distribution modeling (SDM) has been widely used to predict the distribution of invasive plant species based on bioclimatic variables. However, the specific selection of these variables may affect the performance of SDM. This investigation elucidates a new bioclimate variable dataset (i.e., CMCC-BioClimInd) for its use in SDM. The predictive performance of SDM that includes WorldClim and CMCC-BioClimInd was evaluated by AUC and omission rate and the explanatory power of both datasets was assessed by the jackknife method. Furthermore, the ODMAP protocol was used to record CMCC-BioClimInd to ensure reproducibility. The results indicated that CMCC-BioClimInd effectively simulates invasive plant species’ distribution. Based on the contribution rate of CMCC-BioClimInd to the distribution of invasive plant species, it was inferred that the modified and simplified continentality and Kira warmth index from CMCC-BioClimInd had a strong explanatory power. Under the 35 bioclimatic variables of CMCC-BioClimInd, alien invasive plant species are mainly distributed in equatorial, tropical, and subtropical regions. We tested a new bioclimate variable dataset to simulate the distribution of invasive plant species worldwide. This method has great potential to improve the efficiency of species distribution modeling, thereby providing a new perspective for risk assessment and management of global invasive plant species.
Multipotent Mesenchymal Stem Cell-Based Therapies for Spinal Cord Injury: Current Progress and Future Prospects
Authors: Zeng Chih-Wei
Published: April 2023

Spinal cord injury (SCI) represents a significant medical challenge, often resulting in permanent disability and severely impacting the quality of life for affected individuals. Traditional treatment options remain limited, underscoring the need for novel therapeutic approaches. In recent years, multipotent mesenchymal stem cells (MSCs) have emerged as a promising candidate for SCI treatment due to their multifaceted regenerative capabilities. This comprehensive review synthesizes the current understanding of the molecular mechanisms underlying MSC-mediated tissue repair in SCI. Key mechanisms discussed include neuroprotection through the secretion of growth factors and cytokines, promotion of neuronal regeneration via MSC differentiation into neural cell types, angiogenesis through the release of pro-angiogenic factors, immunomodulation by modulating immune cell activity, axonal regeneration driven by neurotrophic factors, and glial scar reduction via modulation of extracellular matrix components. Additionally, the review examines the various clinical applications of MSCs in SCI treatment, such as direct cell transplantation into the injured spinal cord, tissue engineering using biomaterial scaffolds that support MSC survival and integration, and innovative cell-based therapies like MSC-derived exosomes, which possess regenerative and neuroprotective properties. As the field progresses, it is crucial to address the challenges associated with MSC-based therapies, including determining optimal sources, intervention timing, and delivery methods, as well as developing standardized protocols for MSC isolation, expansion, and characterization. Overcoming these challenges will facilitate the translation of preclinical findings into clinical practice, providing new hope and improved treatment options for individuals living with the devastating consequences of SCI.