bluuebunny/crossref_metadata_2025 huggingface dataset:
Comportamiento de las enfermedades hepáticas en una cohorte de pacientes colombianos con COVID 19
Authors: Sánchez Pardo Santiago , Garzón Orjuela Nathaly , Prieto Ortíz John Edison , Prieto Ortíz Robin Germán , Eslava Schmalbach Javier H.
Published: June 2022

Introducción: la infección por coronavirus del síndrome respiratorio agudo grave de tipo 2 (SARS-CoV-2) concentra la mayor atención en el momento. En el hígado es frecuente la elevación asintomática de transaminasas y la afectación hepática varía del 14 % al 78 %. La evaluación de las comorbilidades hepáticas es escasa, con prevalencias que oscilan entre el 2 % y el 11 %.

Objetivo: describir el comportamiento de una cohorte de pacientes con enfermedades hepáticas que presentaron el coronavirus de 2019 (COVID-19).

Materiales y métodos: estudio observacional retrospectivo que analizó el comportamiento de una cohorte de pacientes con hepatopatías que enfermaron por COVID-19.

Resultados: 543 pacientes padecieron por COVID-19, de los cuales 300 fueron mujeres (55,3 %). La mediana de edad al diagnóstico de la enfermedad hepática fue de 52 años. Las principales causas de las hepatopatías fueron esteatohepatitis no alcohólica (49,5 %), enfermedad colestásica (7,7 %), virus de la hepatitis C y B (6,3 %). La alanina-aminotransferasa (ALT) presentó una mediana de 52 U/L (rango intercuartílico [RIC]: 30-98) y aspartato-aminotransferasa (AST) 32 U/L (RIC: 23-62). La mortalidad por la infección viral fue del 5,7 % con una tasa de incidencia de 2,9 (intervalo de confianza [IC] 95 %: 2-4,2).

Conclusiones: es un estudio de carácter retrospectivo; sin embargo, hasta la elaboración del manuscrito es la primera cohorte en Colombia en describir el comportamiento de las enfermedades hepáticas en pacientes que enferman de COVID-19. No se encontraron diferencias estadísticamente significativas entre las causas de hepatopatía que confieran un mayor riesgo de mortalidad; sin embargo, tener una descompensación de cirrosis es la única condición que tiene una relación con la mortalidad.
The Comparison of Pneumonia-Careseekers Between Rural and Urban Areas of Developing Nations
Authors: Villaroman Aimee-Aila , Ebona Jenna Joyce M. , Rafael Erika Allanis Adelet D. , Reyes Raine
Published: June 2022

Data from UNICEF on the percentage of pneumonia careseekers were
subjected under descriptive and inferential statistical analysis to
compare the percentage of pneumonia careseekers in rural and urban areas
in developing countries. Prior to the two sample t-test, the data was
first subjected to Levene’s test and found that equal variances cannot
be assumed so Welch’s test was done. We reject the null hypothesis
because the two areas, rural and urban, have a statistically significant
difference in sample means, with t= -6.8227 and p = 0.00003858092. A
comparison of the individual t-scores of careseekers in urban and rural
areas worldwide reveals that more treatment was sought in urban areas
compared to rural areas as the years progress. The data was also
subjected to linear regression test and it was found that linear
relationship exists between rural careseekers and time (p=0.001636),
while there is no linear relationship between urban careseekers and time
(p=0.07574). Linear relationship is also observed between rural and
urban careseekers combined and the year (p=0.02349).
Confirmation in an Animal Model That RSV Productively Infects and Persists in Key Cells Involved in Immunological Memory
Authors: M Angela Fonceca , Lauzon-Joset Jeff , ScottPhD Naomi , A Philip Stumbles , Strickland Deborah , L Mark Everard
Published: June 2022

Respiratory syncytial virus (RSV) causes annual epidemics of acute
respiratory disease in large part because antibody levels fall rapidly
after infection. RSV is able to infect cultured dendritic cells (DCs)
and persist in these cells. Given the importance of DCs in antigen
presentation, RSV infection and persistence is likely to be an
evolutionary adaptation that can subvert the host immune response. This
study aimed to demonstrate infection and persistence of RSV in lung DCs
using an in vivo model of RSV infection. Mice were infected with
a modified strain of RSV which expresses a red fluorescent protein
(RSV-RFP) when replicating. Clinical symptoms of infection were
monitored using weight change and inflammatory cell counts from
bronchoalveolar lavage, which were correlated to RSV viral titre
(quantitative PCR). Lung tissues were collected at 3, 5, 7 and 21 days
post-infection (dpi) to assess leukocyte populations by flow cytometry.
Clinical symptoms and RSV viral load peaked at 5 dpi. RSV-RFP was most
prevalent in macrophages at 3 dpi and observed in B cells and DCs. At 21
dpi, RSV-RFP remained evident in a subset of conventional DCs (CD103
CD11b ) even though clinical
symptoms and pulmonary inflammation had resolved. This data indicates
that RSV infects, replicates in and persists in a sub-population of lung
cDCs after resolution of symptoms and clearance of virus from the
airways. Understanding the implications of this adaptation is likely to
provide crucial insights into the virus’s ability to generate annual
epidemics of respiratory disease.
Evolution of population dynamics following invasion by a non-native predator
Authors: Einum Sigurd , Ullern Emil , Walsh Matthew , Burton Tim
Published: June 2022

Invasive predatory species are frequently observed to cause evolutionary
responses in prey phenotypes, which in turn may translate into evolution
of the prey’s population dynamics. Research has provided a link between
rates of predation and the evolution of prey population growth in the
lab, but studies from natural populations are rare. Here we tested for
evolutionary changes in population dynamics parameters of zooplankton
Daphnia pulicaria following invasion by the predator Bythotrephes
longimanus into Lake Kegonsa, Wisconsin, US. We used a resurrection
ecological approach, whereby clones from pre- and post-invasive periods
were hatched from eggs obtained in sediment cores and were used in a
3-month growth experiment. Based on these data we estimated intrinsic
population growth rates (r) and carrying capacities (K) using
theta-logistic models. We found that post-invasion Daphnia maintained a
higher r and K under these controlled, predation-free laboratory
conditions. Thus, whereas previous experimental evolution studies of
predator-prey interactions have demonstrated that genotypes that have
evolved under predation have inferior competitive ability when the
predator is absent, this was not the case for the Daphnia. Given that
our study was conducted in a laboratory environment and the possibility
for genotype-by-environment interactions, extrapolating these apparent
counterintuitive results to the wild should be done with caution.
However, barring such complications, we discuss how selection for
reduced predator exposure, either temporally or spatially, may have led
to the observed changes. This scenario suggests that complexities in
ecological interactions represents a challenge when predicting the
evolutionary responses of population dynamics to changes in predation
pressure in natural systems.
Population pharmacokinetics and hemorrhagic risk analysis of rivaroxaban in Chinese elderly patients with non-valvular atrial fibrillation
Authors: Zhang Dan , Chen Wenqian , Qin Wei , Du Wenwen , Wang Xiaoxing , Zuo Xianbo , li pengmei
Published: June 2022

Aim: The aim of this study was to establish a population pharmacokinetic
(PPK) model for rivaroxaban in Chinese elderly patients with NVAF to
evaluate precision dosing regimens and analyze hemorrhagic risk after
rivaroxaban treatment. Method: A population pharmacokinetic model was
developed using the nonlinear mixed-effects model (NONMEM). The plasma
concentration of rivaroxaban was detected by UPLC-MS/MS method and the
gene polymorphisms were detected by Sanger dideoxy DNA sequencing
method. A Monte Carlo simulation was performed to evaluate various
dosing schemes and different levels of covariates for the target range
of therapeutic drug monitoring concentrations (Cmax,ss, Cmin,ss).
Exposure of rivaroxaban was simulated and assessed in hemorrhagic risk
evaluation. Results: Model-building dataset including 360 plasma
concentrations from 180 Chinese elderly patients (median age 81year). A
one-compartment population PK model with estimated glomerular filtration
rate (eGFR), total bilirubin (TBIL) and ABCB1 rs1045642 as major
covariates for apparent clearance were developed. The average
probability of target attainment (PTA) of optimal dosing regimens with
different covariates levels for targeted Cmax,ss and Cmin,ss were
29.35%-31.30% and 64.91%-65.80%, respectively. 10 mg of rivaroxaban
in Chinese elderly patients with normal renal and liver function was
appropriate. AUC24,ss was statistically significant associated with the
increased risk of the bleeding events (OR 1.0006; 95%CL 1.0003-1.001;
p<0.0001). Conclusion: Lower dose is recommended for older
patients with renal impairment to avoid overexposure and bleeding
events. The population pharmacokinetic model could inform individualized
dosing for Chinese older NVAF patients with rivaroxaban anticoagulation
therapy.
Skin improvement effects of phytosterol ester derived from rice bran
Authors: Kobayashi Mizuka , Nakagawa Shiori , Nakamura Toshio , Tsuno Takuo
Published: June 2022

Rice bran contains an abundance of phytosterols. We have developed
“Riceterol EsterTM” (RSE), which consists of a phytosterol ester and
fatty acids made from the by-product of extracting oil from rice bran.
RSE has been registered as a cosmetic ingredient in rice bran-derived
products, and its physical functions, such as its high water retention
and emollient effects, are evident, although its biological functions
remain poorly understood. In this study, we clarified the biological
effectiveness of RSE. Treatment of 0.01% RSE to normal human
fibroblasts cell (Hs68) resulted in increased amounts of hyaluronic acid
and type III collagen. On the other hand, in the face application test
with human volunteers, a significantly reduced amount of trans-epidermal
water loss (TEWL) was found in the 8th and 12th weeks. By image
analysis, improvements in facial redness and pore troubles were also
observed using a visual analog scale (VAS) questionnaire. It is
suggested that RSE improves barrier function and maintains the repair of
the dermis structure.
Odevni narativi - uvod u temat
Authors: Ivanovic-Barisic Milina
Published: June 2022

nema
By musealizing the camouflage suit to a new clothing narrative
Authors: Stojanovic Marko
Published: June 2022

The primary function of introducing the so-called ?camouflage suit? or camo suit into the military and police formations in the late 1980s also had the consequence of transferring its functions to a secondary level, by the sheer proliferation ofsuch sets used in war activities during the breakup of the former Yugoslavia. For the ethnographic heritage, the challenge of the liminal status of the camouflage suit within the framework of men?s work pattern in the redefined folk economy is reflected in the short period of its establishment and use. On the other hand, its widespread use and an ongoing cultural phenomenon support the musealization of samples of such a clothing pattern, as well as the need to set up research on the impact of folk economy on clothing culture and vice versa. As camouflage suits were obtained and used in the process of integration into the everyday work pattern of members of rural communities, retired men and ?weekend farmers? engaged in agricultural activities, they became a mirror image of the dissolution of late socialism as a social system in Serbia. This new status has contributed to the redefinition of the function and content of new men?s clothing patterns, in line with the broader changes in the value system and redistribution of state and social authority. Consequently, anthropologization of museological discourse creates suitable conditions for discussing the existence of the tertiary communicative role and significance of all types of military apparel, including camouflage suits.
Women’s clothing practice during the XX century in Novi Pazar and surroundings
Authors: Aksic Nina , Ziljkic Hasna
Published: June 2022

In this paper we will present everyday clothing in the city and village,
during the XX century, on the ground of Novi Pazar. The emphasis is placed
on the women`s everyday clothing and special features that are reflected
primarily in confessional practices. In addition to the differences in
clothing that arose from the confessional practices, we will point out to
the others aspects which influenced on the diversity of clothing, such as -
education, employment, the influence of the external environment (people
outside the family, the media and etc.), economic status etc. Differences
conditioned by the status of women in society, which changed significantly
after World War II, with greater emancipation of women and their gradual
exit from the patriarchal family framework caused changes in clothing
appearance. The aim of this paper is to present the complexity of everyday
clothing practices of women and its changes in the territory of Novi Pazar
and its environment.
Brief Pictorial Quizzes to Assess Carbohydrate Counting and Nutrition Knowledge in Youth With Type 1 Diabetes
Authors: Waheed Myra , Lin Tyger , Thivierge Meredith , Seel Maureen , Prichett Laura , Brown Elizabeth A. , Wolf Risa M.
Published: June 2022

Available assessments of patient nutrition knowledge and carbohydrate counting ability are lengthy. This article reports on a study to implement and validate a series of brief nutrition quizzes of varying difficulty for use in pediatric type 1 diabetes. Among 129 youth with type 1 diabetes, participants completed an average of 2.4 ± 1 of the six quizzes, with a median score of 4.7 of 5. Higher quiz scores were associated with lower A1C (P <0.001), higher parental education (P = 0.02), and higher income (P = 0.01). Such quizzes can help to identify knowledge gaps and provide opportunities for education, which may improve glycemic outcomes in youth with type 1 diabetes.
Frequency of Ketoacidosis at Diagnosis of Pediatric Type 1 Diabetes Associated With Socioeconomic Deprivation and Urbanization: Results From the German Multicenter DPV Registry
Authors: Auzanneau Marie , Rosenbauer Joachim , Warncke Katharina , Maier Werner , Kamrath Clemens , Hofmann Thomas , Wurm Michael , Hammersen Johanna , Schröder Carmen , Hake Kathrin , Holl Reinhard W.
Published: June 2022

OBJECTIVE

To investigate whether socioeconomic deprivation and urbanization are associated with the frequency of diabetic ketoacidosis (DKA) at diagnosis of pediatric type 1 diabetes.

RESEARCH DESIGN AND METHODS

Children and adolescents aged ≤18 years, living in Germany, with newly diagnosed type 1 diabetes documented between 2016 and 2019 in the Diabetes Prospective Follow-up Registry (DPV; Diabetes-Patienten-Verlaufsdokumentation), were assigned to a quintile of regional socioeconomic deprivation (German Index of Socioeconomic Deprivation) and to a degree of urbanization (Eurostat) by using their residence postal code. With multiple logistic regression models, we investigated whether the frequency of DKA at diagnosis was associated with socioeconomic deprivation or urbanization and whether associations differed by age-group, sex, or migration status.

RESULTS

In 10,598 children and adolescents with newly diagnosed type 1 diabetes, the frequency of DKA was lowest in the least deprived regions (Q1: 20.6% [95% CI 19.0–22.4], and increased with growing socioeconomic deprivation to 26.9% [25.0–28.8] in the most deprived regions [Q5]; P for trend <0.001). In rural areas, the frequency of DKA at diagnosis was significantly higher than in towns and suburbs (intermediate areas) or in cities (27.6% [95% CI 26.0–29.3] vs. 22.7% [21.4–24.0], P < 0.001, or vs. 24.3% [22.9–25.7], P = 0.007, respectively). The results did not significantly differ by age-group, sex, or migration background or after additional adjustment for socioeconomic deprivation or urbanization.

CONCLUSIONS

This study provides evidence that prevention of DKA at diagnosis by means of awareness campaigns and screening for presymptomatic type 1 diabetes should particularly target socioeconomically disadvantaged regions and rural areas.
Manipulation under anesthesia after total knee arthroplasty: a retrospective study of 145 patients
Authors: Sala Julius , Jaroma Antti , Sund Reijo , Huopio Jukka , Kröger Heikki , Sirola Joonas
Published: June 2022

Background and purpose: Manipulation under anesthesia (MUA) is considered to be effective in treating stiffness after total knee arthroplasty (TKA). However, not all patients achieve a satisfactory range of motion (ROM) after MUA. This retrospective study determined the outcome of MUA and identified the factors affecting it.Patients and methods: The final sample consisted of 150 MUAs performed on 145 patients. The parameters of interest were ROM and Knee Society Score (KSS) or Oxford Knee Score (OKS). The associations of preoperative, perioperative, and postoperative risk factors with gain in flexion and flexion at post-MUA follow-up (an average of 2 months after MUA) were analyzed using multivariable regression model.Results: The mean of 26° (95% CI 23–29) gain in flexion and the mean of 3° (CI 2–4) gain in extension were noticed at post-MUA follow-up when compared with the ROM preceding MUA. The mean post-MUA-FU flexion was 99° (CI 97–102) and the mean post-MUA-FU extension deficit was 4° (CI 2–5). KSS (121 vs. 129) and OKS (29 vs. 28) were similar before and after MUA. The early timing of MUA was associated with better gain in flexion –0.04 (CI –0.08 to –0.01), while we found no association between the timing of MUA and flexion after MUA –0.004 (CI –0.03 to 0.03). High BMI was associated with better gain in flexion 0.8 (CI 0.2–1.5).Interpretation: We found that ROM improved substantially after MUA. The gain in flexion decreased as the time between TKA and MUA increased.
IMITATION TECHNIQUE IN LEARNING ENGLISH AT ENGLISH EDUCATION DEPARTMENT UNIVERSITAS NEGERI MANADO
Authors: F. Lengkoan  , P.L. Hampp
Published: June 2022

English as a foreign language is something interest to learn even though it is not easy to learn. In learning English many teachers were try some media, method, strategy, and technique. The aim of this research is to describe how the use of imitation technique is effective in learning English. In this research the researcher used imitation technique in learning English to improve students’ pronunciation and listening skill. By used video the students imitate what are the speaker say, before that they must listen carefully what speaker say. In this research consists of 20 students in third semester and used three videos. This research applied in three treatments. The result showed the student receive better improvement in learning English. The findings in the analysis it showed the improvement of students’ pronunciation is increased from 22.85 to 0.95 incorrect words and the improvement of listening is increased from 28.2 to 78.7, and it concluded that imitation technique is effective technique in learning English. When the words pronounced correctly it was help to recognize the words in case listening skill. In COVID-19 pandemic it is possible to use media such as video youtube in teaching and learning process even though technology could not replace the teacher position but technology will be distributor the knowledge from teacher to student.
READING AL-QUR’AN AS PUNISHMENT FOR BELATED STUDENTS IN EFL CLASSROOM: THE STUDENTS’ PERSPECTIVE VIEWS
Authors: A. Rahmat
Published: June 2022

The objective of this research was to find out the students’ perspective toward reading Al-Quran as a punishment for belated students in EFL classroom. The researcher employed descriptive qualitative research design to analyze the students’ perspective regarding with reading Al-Qur’an as punishment for belated students in EFL classroom. The participant of this research was the EFL students of Manajemen Informatika in academic year 2019/2020 at STMIK Handayani Makassar. The researcher chose 12 students as a sample of this research randomly. The instrument of this research was self-report questionnaire. The result showed that applying reading Al-Qur’an as a punishment for belated students in EFL classroom is very well to be applied because a lot of perspectives of the students illustrate a positive views regarding with the application of this kind of punishment. This punishment is educative punishment because of able to motivate the students for not coming late, train the students to be discipline, make the students are getting closer with Al-Qur’an in their life and getting the rewards. Hopefully, this kind of punishment can be applied by the teachers to educate the students for not coming late in the classroom.
Pengaruh Perbedaan Jumlah Hidden Layer dan Node pada Hidden Layer Terhadap Performa Model Klasifikasi Diabetes
Authors: Suprana I Nyoman Arya
Published: June 2022

Diabetes merupakan salah satu penyakit kronis yang serius. Diabetes umumnya ditandai dengan tubuh tidak membuat cukup insulin atau tidak dapat menggunakan insulin yang dibuat seefektif yang dibutuhkan. Diabetes dapat dikelompokkan menjadi empat tipe. Semua tipe diabetes dapat menyebabkan komplikasi pada berbagai bagian tubuh dan dapat meningkatkan risiko kematian dini. Pada paper ini, dilakukan penelitian dalam membangun model menggunakan algoritma multilayer perceptron di WEKA untuk mengklasifikasikan seseorang menderita diabetes. Dataset yang digunakan adalah “Diabetes Health Indicators Dataset” yang bersumber dari Kaggle. Terdapat tujuh percobaan yang dilakukan yang mana hasil terbaik ditunjukkan oleh percobaan 7 berdasarkan parameter performa F-measure.
Interaction in the Mathematics Class: The Shaping Process of Inquiry-based Learning
Authors: Nika Stella D. , Brailas Alexios V.
Published: June 2022

This paper focuses on the forms of interaction that occur in a mathematics class. It explores ways to assist students in adopting the practice of questioning and improving their ability to participate in the mathematics lesson. In particular, the study examines how the practice of student questioning can affect communication. By describing the shaping process of an inquiry-based learning class, it proposes an exploratory method to introduce students to the mathematical practice of questioning. The main outcome of the study is that the dynamic presence of student inquiry can significantly transform traditional mathematical communication in the classroom into alternative forms.
Development of Criterion for Test and Assessment of Academic Results of High-Quality Curriculum for Students Majoring in Basketball of Sport Training Discipline under Bac Ninh Sport University (Vietnam)
Authors: Duc Toan Pham , Thanh Binh Nguyen
Published: June 2022

The research process has developed the criterion for test and assessment of academic results of high quality curriculum for students majoring in Basketball of Sport Training discipline in each module in accordance with the curriculum’s practical conditions aiming to accurately assess learners' competencies and ensure the enhanced quality of training for bachelors of Bac Ninh Sport University.
Examining the Effectiveness of Mentoring Process in Developing Teaching Competencies of Secondary School Novice Teachers: A Case of Mbeya Region in Tanzania
Authors: Ally Mussa Shabani , Libent-Mabagala Daphina
Published: June 2022

Mentoring programmes are cost effective for both novices and practicing secondary school teachers as when carried out earlier, become competent and confident. Yet, a few studies have been conducted in Tanzania in particular Mbeya region on the matter. The study examined the effectiveness of mentoring process in developing teaching competencies of the secondary school novice teachers in Mbeya region, Tanzania. Padua’s theory, Social cognitive theory and Herzberg two factor theories guided the study. Case study design with mixed approaches was used. A sample size of 110 novice and experienced teachers was administered with questionnaires and interview guide respectively. Descriptive statistics aided in analysing quantitative data while content analysis served for qualitative data. The findings revealed that mentoring programs resulted into confidence and command among novice teachers where mentors cultivate specific ideas among mentees in facilitating teaching and learning. Yet, mentoring programs contributed to the professional development of novice teachers with personal support to cope with their new work environment. It was concluded that mentorship effectively develops novice teachers’ competencies and recommended that mentors should cultivate further understanding of how to help novice teachers and how to create mentoring goals to support novice teachers’ progress in the beginning of their teaching career.
Towards Enhancing Quality Physical Education Lessons: The Role of Improvisation
Authors: Aboagye Emmanuel , Armoh Ebenezer K. , Marcourt Samuel R. , Dougblor Vivian V. , Ossei-Anto Theophilus A.
Published: June 2022

The role of improvisation is crucial in the formation of new ideas, and it is paramount where real objects are difficult to come across. However, there is little literature on the role of improvisation in the classroom teaching and teacher education context and how its practices in teaching could enhance education, as well as students learning in different contexts and domains. Therefore, this study examined the perceptions of student-teachers at colleges of education in Ghana on the role of improvisation in enhancing quality Physical Education lessons. The study adopted a qualitative approach as the research design to collect data from 10 student-teachers. The instrument used to gather the data was semistructured interviews while purposive and random sampling techniques were employed to select the participants. Thematic analysis was the main tool for the data analysis. The study revealed five themes namely: (1) promote understanding and maximise learners’ participation, (2) Reduce cost and expenditure, (3) Assist to achieve learning objectives (4) Promote creativity and innovation and (5) Make the learning experience real. These themes provide evidence of the role of improvisation in enhancing quality physical education lessons among college of education students in the Ashanti Region of Ghana. The study recommends that teachers should be creative and have in-depth knowledge of improvisation to assist in effective teaching and learning to improve learners’ experiences.
RELATIONSHIP BETWEEN BLOOD PRESSURE, BODY WEIGHT INDEX AND ANTHROPOMETRIC, METABOLIC-HORMONAL PARAMETERS IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION
Authors: Semianiv М.М.
Published: June 2022

The aim of the study – to evaluate changes in clinical and laboratory parameters andto analyze the relationship between blood pressure (BP), body mass index (BMI) andanthropometric, metabolic and hormonal parameters in patients with essential arterialhypertension (EAH).Material and methods. 100 subjects with EAH and target- organ damaging (2nd stage),moderate, high, very high cardiovascular risk were involved in the case-control study.There were 70.84% females, 29.16% males, the mean age 57.86±7,81 years. The controlgroup consisted of 60 healthy individuals, who did not diff er by sex and age (p>0.05).Pearson’s χ2-test was used to establish the relationship between the parameters, in the caseof categorical variables; ANOVA variance analysis, if one of the variables is categorical

and the other is numerical (interval), in the case of abnormal array distribution – non-parametric Kruskal- Wallis test.

Results. The development and course of EAH is characterized by clinical- hemodynamicand metabolic disorders that are nonlinearly exacerbated with the severity of hypertension.ANOVA analysis showed that BP is directly related to age (F=7.46; p<0.001), bodyweight (F=4.32; p=0.048), height (F=5.60; p=0.04), waist circumference (WC) (F=7.61;p=0.043), as well as WC/HC (2

=6.75; =0.004), glucose level (2

=9.41; p=0.003),

vitamin D and parathyroid hormone (PTH) (2

=6.08; p=0.043 and 2

= 19.34; p=0.013),respectively. Body mass index (BMI) is expected to be strongly associated with BP(2= 40.06; p<0.001), WC/HC (2

=12.13; p=0.007), blood glucose and vitamin D

(2=19.11; p<0.001 and 2

16.12; p=0.001), bordering on heredity for cardiovascular

diseases (2=7.72; p=0.052).Conclusions. BP is directly related to age, body weight, height, WC (F=4.32-7.46;p<0.048-0.001), as well as WC/HC, glucose level, vitamin D and PTH (2

=6.08-19.34;

р=0.043-0.003). BMI is strongly associated with WC (2

=40.06; p<0.001), WC/HC

(212.13; p = 0.007), blood glucose and vitamin D concentration (2

= 19.11; p<0.001;

2= 16.12; p = 0.001).
GENETIC DETERMINATION OF ENDOTHELIAL FUNCTION AND «INTIMA-MEDIA» THICKNESS OF CAROTID ARTERIES IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Sydorchuk A.R.
Published: June 2022

Endothelial regulation of vascular tone is an important component of the infl uence onblood pressure (BP).Objective – to study the changes in endothelial function and the «intima- media» thickness(IMT) of the carotid arteries depending on the genes polymorphism GNB3 (rs5443) andNOS3 (rs2070744) in essential arterial hypertension (EAH).Materials and methods. 100 patients with EAH 2nd stage and 48 practically healthypersons (control group) participated in the study. Soluble Vascular Cell AdhesionMolecule (sVCAM-1), total NO metabolites (NO2–+NO3–), transcriptional activity ofNOS3 gene, Endothelium- Dependent Flow- Mediated Dilation of the Brachial Artery(FMD BA) and carotid IMT were studied. NOS3 (rs2070744) and GNB3 (rs5443) geneswere investigated by Real- Time PCR.Results. Severe EAH is accompanied by an IMT increase 50.0-57.14% (p<0.01), NOS3gene expression after mRNA level decrease 34.54% (p=0.003), more often atheroscleroticplaques on the carotid arteries 24.77-27.62% (p<0.05). The polymorphic site of theNOS3 gene (rs2070744) is associated with a total NO metabolites value decrease,transcriptional activity of the NOS3 gene decrease (F=71.11 and F=8.71; p<0.001)and sVCAM-1 level elevation (F=6.96; p=0.002), especially in minor C-allele carriers(more severe in CC-genotype). ANOVA has not shown an association of the GNB3 gene(rs5443) with endothelial function and carotid artery IMT in EAH patients.Conclusions. The polymorphic site of the NOS3 gene (rs2070744) is associated withendothelial function changes and does not aff ect the IMT of the carotid arteries.
Number and Things
Authors: Martínez María Laura
Published: June 2022

Ian Hacking has repeatedly pointed out the influence that the work of Michel Foucault had early in his work, an influence that came mainly through his reading of Foucault’s Les Mots et les Choses (1966). In this sense, it is reasonable to trace the Foucauldian lineage in many of the notions Hacking proposes for “how we found out how to find out” (Hacking 2010, April 21, 3), and, more particularly, in the latter’s assessment of how to work in the human sciences is carried forth. However, I argue that Foucault exerted an even more fundamental influence that underlies the totality of Hacking’s work: namely, having stimulated Hacking’s interest in analyzing the historical conditions of possibility of the emergence of scientific objects and concepts. To show this, in this article, I first focus on two works by Hacking—The Emergence of Probability (1975) and Why Does Language Matter to Philosophy? (1975a)—in which he adopts an archeological perspective which, I argue, clearly adumbrates Foucault’s influence. I then turn to The Taming of Chance (1990), Rewriting the Soul (1995) and Mad Travelers (1998), where I contend that, added to the archeological contributions, it is possible to identify traces of Foucault’s genealogical period.
Heterotopia as a Reconstruction of the History of Ideas
Authors: Santos Débora Bráulio
Published: June 2022

This paper proposes an analysis of the work The order of things by Michel Foucault, based on the notion of heterotopia, to demonstrate that the author develops there an original procedure of re-reading the history of ideas, which consists of the rearrangement of elements canonized by historiography, creating new relations between them, as well as in the insertion of unusual or heterodox elements. We then show how Ian Hacking reappropriates this heterotopic procedure in The emergence of probability and how it influences the heart of the author’s philosophical project, whose unique reading of archaeology brings it back to epistemology, either through the idea of “immature science” or through his notion of “styles of scientific reasoning.” Understanding the conditions for the formation of our ideas denaturalizes our current ways of thinking, opening new possibilities for thought and action. The relevance and potential that this heterotopic procedure has for contemporary epistemology are thus evident.
L’État, C’est Moi?
Authors: Quiroga-Villamarín Daniel R.
Published: June 2022

Across the humanities and the social sciences, Foucault’s work has often taken wildly divergent routes. As an unexpected corollary, some of his interventions have been compartmentalized into different fields — with few attempts to read his different contributions across disciplinary boundaries. Conversely, in this article, I place Foucault’s early works on the history of Western systems of thought (and, in particular, The Order of Things) with some of his later interventions on sovereignty and punishment (and, in particular, Security, Territory, Population and Discipline & Punish). I draw from his early archeological explorations of the Western episteme(s), which have not been comprehensively explored by legal scholars, to reread his later works as an archeological exploration of the production of knowledge relative to sovereignty. This allows placing Foucault’s early epistemological and methodological concerns at the forefront of his later work on the “withering away” of public law in the Western imagination.
Foucault and the “Noble Sciences”
Authors: Rocha Jorge Alberto
Published: June 2022

“Noble sciences” was a term sometimes used by Michel Foucault to refer mostly to Mathematics and Physics (and, to a lesser extent, Chemistry). This article explores this notion, based on Dits et écrits, understanding that there is a strong connection between this term and a reflection on “enlightenment”, or Aufklärung. But how has this heritage unfolded in our days? We will discuss this theme, advancing to the text “La vie: l’experience et la science”, where another important associated question will appear: how to understand what can give Philosophy “dignity” amid the extension of that Kantian tradition?
The principle of humanism and its content in the formation of a new paradigm in law
Authors: Hromovchuk M.
Published: June 2022

It is determined that human and civil rights are the most important institution, which has been developed not only in constitutional law, but also in the theory of law and in other sectoral legislation. In the second half of the XX century, this institution came to the fore, both domestically and internationally. The Institute of Human and Civil Rights and Freedoms is one of the most significant results of the legal development of society, from ancient times to the present day, when human rights have become an essential attribute of a democratic state governed by the rule of law. The modern approach with the declared principles of democracy is somewhat outdated and the whole world needs to rethink the acquired and find new approaches to understanding equality, justice, protection, etc.

The necessary stability of the concept of protection of human and civil rights and freedoms is achieved by relying on a system of principles tested by science and practice. The viability and progressiveness of this concept is formed through a combination of legal, moral, traditional, and other socio-regulatory norms. Taking into account such an approach will prevent legal negativity from becoming a dominant phenomenon of the legal system, restrain the onslaught of legal nihilism and indifference.

It is indicated that the principles are a kind of indicators that demonstrate the degree of development of the law itself, starting points that show the vector of legal regulation. Of course, the principles of law should reflect and express the basic values on which the law is focused, to carry the basis of “ideal” law. The purpose of legal principles is to ensure the ideological unity of lawmaking, law enforcement and law and order in general. They permeate the entire legal system of society, focusing its development on universal, most valuable ideals: democracy, justice, equality, humanism, individual freedom, etc.

Definitely, humanism, as a legal category, is a worldview that considers man as a higher, self-sufficient and self-aware value. Humanism expresses the attitude to man in at least two ways: Thus, humanism is a certain moral requirement for human behavior, ie a certain category of moral awareness of man of the highest social value in the state.
The State and Revolutions. Part VI. The political and legal stability as the base of the social welfare
Authors: Kononenko Yu. , Dzholos S.
Published: June 2022

The article is devoted to the general-theoretical grounds of the political stability as the base of the social welfare.

It was found that the transition from the one to another socioeconomic formation not always lead to the progress and positive changes of the quality of social life. The authors say that in reality the welfare of the human and society depends on the evolvement of the scientific and technical progress, technological, productive and economic factors of development, which are based on the stability, given and guaranteed by the state. The state was characterized as the highest value and the most important invention of the humanity, which guarantees peace, safety, welfare and social development with the help of the management and integrating of efforts of separate people. It was found that the role and significance of the state constantly growths, proportionally to the increasing complexity of the social life and necessity to manage its activities. It was emphasized that stability of the state is one of the most important elements of its value, because it guarantees

the orderly development and normal being of the society.

It was found that the constitutional monarchy and the presidential republic are the most appropriate forms of government, which ensure stability. The authors say that the domination of the executive power and the authoritarian regime helps to guarantee the stability. The authors emphasize that undemocratic regimes may achieve the high level of efficiency and legitimacy, as it is proved by the previous experience of the etatistic Turkey, USSR, the Third Reich, China, Libya, Belarus, as well as the Napoleonic France and numerous absolute monarchies of the early modern period (France of the epoch of Louis XIV, Russia of the epoch of Peter I and Catherine II, Prussia of the epoch of Frederick II, etc.) and so on.

The authors criticize the multi-party system, which shows the immaturity of the political system of society, which may lead to the fall of the statehood with the total disarray in the background. It was substantiated that the single-party and two-party system play the important role in the context of the social stability ensure. The authors emphasize on the necessity of the establishment of the simple-majority single-ballot system to ensure the formation of the two-party system, etc.
Determining the future status of Transcarpathia after the First World War: diplomatic, legal, historical aspects
Authors: Panov A.
Published: June 2022

An attempt is made to consider the peculiarities of diplomatic, legal and historical aspects of determining the future status of Transcarpathia after the First World War. It is pointed out that for many peoples of the Austro-Hungarian Empire, the First World War, in which they were involved against their will, gave the opportunity for radical changes in their further development, including the opportunity to gain freedom. It was established that the low level of culture, the small number of its own intelligentsia, interfaith misunderstandings and conflicts, the lack of its own literary language allowed the Hungarian authorities to manipulate the local Ruthenian population for their own purposes.

It is noted that in the early twentieth century, before and during the First World War, Ruthenian politicians did not develop a specific concept of state and legal status of Transcarpathia. Inherent in the political and legal thought of the time was the attempt to improve their cultural and material position by granting cultural and ecclesiastical autonomy, which was to be established within Hungary. Even during the war, the Ruthenian political elite did not clearly articulate demands to the Hungarian government to change the position of its own people.

The analysis of the works of scientists made in the study made it possible to conclude that although the movement for reunification with Ukraine at this time was massive, it could not be unanimous. Evidence in favor of this conclusion is not only the mentioned reasons and features of sociopolitical life of the region, but also the fact that soon, supporting the position of Uzhgorod and Presov Soviets on joining Czechoslovakia, reoriented all other councils operating in Transcarpathia. In addition, with the occupation of Ukraine by Bolshevik Russia in 1919, the opportunity to unite with the conciliar Ukrainian state was lost. In this situation, the only possible way to ensure the further progressive development of Transcarpathia was to include it in the democratic Czechoslovak Republic.
Trends of scientific views in the field of regulatory and legal support of information security of Ukraine
Authors: Honcharov M.
Published: June 2022

The article considers the conceptual principles of regulatory and legal support of information security in Ukraine from the standpoint of various researchers. The analysis of scientific sources revealed that the regulatory and legal support of information security in general and at the elemental level is characterized by scientific, systematic and has many aspects.

Regulatory support is a scientifically sound, consistent system of legal and other means by which civil society and the state exerts influence on information relations and relations directly related to the development of information security, based on the priority of tasks and objectives that arise before society. Regulatory support is a broader concept compared to regulatory regulation.

Emphasis is placed on the main tasks of the state information policy and the goal of the information security policy of Ukraine is clarified. It is the formation of an open information society as a space of an integral state levels.

The shortcomings of the state information policy of Ukraine in modern conditions are revealed, which are connected with the imperfection of the regulatory framework, the lack of effective state policy, the lack of development of the national information and communication infrastructure.

It is established that the state policy of information security should be based on scientific and methodological developments, systematized and integrated into a single concept. It can be presented as a set of national goals, interests and values, strategies and tactics developed and implemented by public authorities to directly regulate and improve the processes of information interaction in all spheres of society and the state.

Today, one of the important areas of the strategy of regulatory and legal support of information security of Ukraine is the analysis and improvement of regulatory and legal regulation in this area.
Right to use the intellectual property objects in the architecture sphere
Authors: Tarasenko Kh.
Published: June 2022

The article is dedicated to the analysis of current issues of legal protection of intellectual property objects in the architecture sphere. There were analyzed intellectual property rights to architectural objects.

It is established that the subjects of intellectual property in the field of construction are endowed with both personal non-property (moral) rights and property rights of intellectual property. It is proved that the norm of Art.30 of the Law of Ukraine “On Architectural Activity” is the only special norm on intellectual property rights in the field of construction regulating the relationship of property rights to architectural objects as objects of copyright. It has been highlighed that a work of architecture is traditionally considered by the legislator as an object of copyright. It is substantiated that the use of a work of architecture most often occurs through reproduction. It is proved that the construction of a building (structure) is of triple legal nature: firstly, it is a way of project documentation use (as a primary object in relation to the actual building); secondly, it is a procedure through which a new work of architecture (really existing object of architecture or urban planning) is created; third, it is a procedure through which a new object of ownership is raised up.

It is substantiated that the author’s right to photo and video recording of an architectural object should be considered as one of the property copyrights, as photo and video recording, in essence, are the ways of a work reproducing. It has been proven that the reproduction of an architectural object can be done by directly copying all the features of appearance, design, planning of an architectural object, and by indirect copying. As an indirect copying of an architectural object should be considered cases when the author reproduces not all, but only part of the creative features of another author’s project, while maintaining the overall style, idea of the object.

It is established that the special patent legislation does not provide for the peculiarities of the use of inventions, utility models, and industrial designs in the field of construction. It has been proven that industrial designs often provide legal protection for the design (interior) of premises, forming a certain corporate style, so the reproduction (copying) of such an interior will be treated as a violation of exclusive property rights to industrial designs.

It has been proved that the registration of a trademark containing an image protected by copyright can be carried out in the presence of exclusive rights to use the architectural work of the applicant.