bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance and Reliability Evaluation of Innovative High-Lift Devices for Aircraft Using Electromechanical Actuators
Authors: Cabaleiro de la Hoz Carlos , Fioriti Marco , Boggero Luca
Published: June 2024

In the last decades, electromechanical actuators started to be introduced in transport aircraft for primary and secondary flight control surfaces. Some innovative architectures have been proposed in the literature to use these actuators for high-lift devices (flaps and slats). The state-of-the-art architecture is built with a central mechanical shaft powered by a power distribution unit connected to ballscrew actuators that actuate the flap and slat surfaces. New innovative concepts have the potential to improve the state-of-the-art architectures. However, there is a lack of quantitative results for such innovative architectures. A new methodology is proposed to preliminarily estimate performance and reliability aspects of conventional and innovative architectures. This allows quantitative comparisons to finally be obtained. The methodology is applied to a new architecture that uses electromechanical actuators for flaps and slats, providing results in terms of performance and reliability and comparing them to the current state-of-the-art high-lift devices. Results show that the new architecture is lighter than the reference one and can be more reliable. This is achieved thanks to the removal of the mechanical links among components, which allows each control surface to be deployed independently from the others. This highly increases the operational reliability of the system. Two cases are analyzed, with and without actuator jamming. This provides more realistic results since this failure mode is currently the main reason why electromechanical actuators are not being used for more applications. The innovative architecture outperforms the conventional one in the case where the electromechanical actuators are not affected by the jamming failure mode.
Detection and Instance Segmentation of Grape Clusters in Orchard Environments Using an Improved Mask R-CNN Model
Authors: Huang Xiang , Peng Dongdong , Qi Hengnian , Zhou Lei , Zhang Chu
Published: June 2024

Accurately segmenting grape clusters and detecting grape varieties in orchards is beneficial for orchard staff to accurately understand the distribution, yield, growth information, and efficient mechanical harvesting of different grapes. However, factors, such as lighting changes, grape overlap, branch and leaf occlusion, similarity in fruit and background colors, as well as the high similarity between some different grape varieties, bring tremendous difficulties in the identification and segmentation of different varieties of grape clusters. To resolve these difficulties, this study proposed an improved Mask R-CNN model by assembling an efficient channel attention (ECA) module into the residual layer of the backbone network and a dual attention network (DANet) into the mask branch. The experimental results showed that the improved Mask R-CNN model can accurately segment clusters of eight grape varieties under various conditions. The bbox_mAP and mask_mAP on the test set were 0.905 and 0.821, respectively. The results were 1.4% and 1.5% higher than the original Mask R-CNN model, respectively. The effectiveness of the ECA module and DANet module on other instance segmentation models was explored as comparison, which provided a certain ideological reference for model improvement and optimization. The results of the improved Mask R-CNN model in this study were superior to other classic instance segmentation models. It indicated that the improved model could effectively, rapidly, and accurately segment grape clusters and detect grape varieties in orchards. This study provides technical support for orchard staff and grape-picking robots to pick grapes intelligently.
Demographic Characteristics and Economic Burden of Clostridioides difficile Infection in Korea: A Nationwide Population-Based Study after Propensity Score Matching
Authors: Cha Jae Myung , Yoon Jin Young , Kwak Min Seob , Lee Moonhyung , Cho Young-Seok
Published: June 2024

Clostridioides difficile infection (CDI) poses a considerable threat to global public health. However, there have been insufficient propensity score-matched data on its demographic characteristics and economic burden. Using nationwide claims data, we assessed longitudinal changes in the demographic characteristics and economic burden of CDI between 2011 and 2019 after propensity score matching. We performed a regression analysis to compare the differences in the length of hospital stay and medical costs between patients with CDI and controls (gastroenteritis and colitis). The CDI hospitalization rate increased 2.9-fold between 2011 and 2019. The CDI group had higher comorbidity index scores and was more frequently diagnosed at tertiary hospitals and in the Seoul region than the control group (all p < 0.001). The annual incidence rate of CDI/10,000 persons significantly increased in both sexes and all age groups. The length of hospital stay and medical costs were 3.3-fold and 5.0-fold greater, respectively, in the CDI than in the control group (both p < 0.001). Although the length of hospital stay decreased, total medical costs increased in all age groups and both sexes between 2011 and 2019 (all p < 0.001). When compared with the control group, the CDI-attributable length of hospital stay and medical cost were greater by 15.3 days and KRW 3413 (×103), respectively, after matching. In conclusion, CDI incidence, particularly among the elderly population with comorbidities, has been increasing. In addition, the length of hospital stay and total medical costs of the CDI group were greater than those of the control group.
Whole-Genome Sequencing of Human and Porcine Escherichia coli Isolates on a Commercial Pig Farm in South Africa
Authors: Strasheim Wilhelmina , Lowe Michelle , Smith Anthony M. , Etter Eric M. C. , Perovic Olga
Published: June 2024

Escherichia coli is an indicator micro-organism in One Health antibiotic resistance surveillance programs. The purpose of the study was to describe and compare E. coli isolates obtained from pigs and human contacts from a commercial farm in South Africa using conventional methods and whole-genome sequencing (WGS). Porcine E. coli isolates were proportionally more resistant phenotypically and harbored a richer diversity of antibiotic resistance genes as compared to human E. coli isolates. Different pathovars, namely ExPEC (12.43%, 21/169), ETEC (4.14%, 7/169), EPEC (2.96%, 5/169), EAEC (2.96%, 5/169) and STEC (1.18%, 2/169), were detected at low frequencies. Sequence type complex (STc) 10 was the most prevalent (85.51%, 59/169) among human and porcine isolates. Six STcs (STc10, STc86, STc168, STc206, STc278 and STc469) were shared at the human–livestock interface according to multilocus sequence typing (MLST). Core-genome MLST and hierarchical clustering (HC) showed that human and porcine isolates were overall genetically diverse, but some clustering at HC2–HC200 was observed. In conclusion, even though the isolates shared a spatiotemporal relationship, there were still differences in the virulence potential, antibiotic resistance profiles and cgMLST and HC according to the source of isolation.
Assessment of Chitosan/Gelatin Blend Enriched with Natural Antioxidants for Antioxidant Packaging of Fish Oil
Authors: Kurek Mia , Ščetar Mario , Nuskol Marko , Janči Tibor , Tanksoić Marija , Klepac Damir , Čakić Semenčić Mojca , Galić Kata
Published: June 2024

In this research, bio-based films were developed using polyelectrolyte complexes derived from chitosan and gelatin for packaging fish oil. To further enhance the antioxidant functionality, the films were enriched with gallic acid and orange essential oils, either individually or in combination. Initially, the films were characterized for their physico-chemical, optical, surface, and barrier properties. Subsequently, the phenolic compounds and antioxidant capacity of the films were assessed. Finally, the films were tested as antioxidant cover lids for packaging fish oil, which was then stored at ambient temperature for 30 days, with periodical monitoring of oil oxidation parameters. This study revealed that the inclusion of gallic acid-induced possible crosslinking effects, as evidenced by changes in moisture content, solubility, and liquid absorption. Additionally, shifts in the FTIR spectral bands suggested the binding of gallic acid and/or phenols in orange essential oils to CSGEL polymer chains, with noticeable alterations in film coloration. Notably, films containing gallic acid exhibited enhanced UV barrier properties crucial for preserving UV-degradable food compounds. Moreover, formulations with gallic acid demonstrated decreased water vapor permeability, while samples containing orange essential oils had lower CO2 permeability levels. Importantly, formulations containing both gallic acid and essential oils showed a synergistic effect and a significant antioxidant capacity, with remarkable DPPH inhibition rates of up to 88%. During the 30-day storage period, fish oil experienced progressive oxidation, as indicated by an increase in the K232 value in control samples. However, films incorporating gallic acid or orange essential oils as active antioxidants, even used as indirect food contact, effectively delayed the oxidation, highlighting their protective benefits. This study underscores the potential of sustainable bio-based films as natural antioxidant packaging for edible fish oil or fresh fish, offering a promising tool for enhancing food preservation while reducing its waste.
Validating the Concept of Mechanical Circulatory Support with a Rotary Blood Pump in the Inferior Vena Cava in an Ovine Fontan Model
Authors: d’Udekem Yves , Van Puyvelde Joeri , Rega Filip , Nix Christoph , Barth Svenja , Meyns Bart
Published: June 2024

Right-sided mechanical support of the Fontan circulation by existing devices has been compounded by the cross-sectional design of vena cava anastomosis to both pulmonary arteries. Our purpose was to investigate whether increasing inferior vena cava (IVC) flow with a rotary blood pump in the IVC only in an ovine animal model of Fontan would lead to acceptable superior vena cava (SVC) pressure. To achieve this, a Fontan circulation was established in four female sheep by anastomosing the SVC to the main pulmonary artery (MPA) and by interposing a Dacron graft between the IVC and the MPA. A rotary blood pump was then introduced in the graft, and the effect of incremental flows was observed at increasing flow regimen. Additionally, to stimulate increased pulmonary resistance, the experience was repeated in each animal with the placement of a restrictive band on the MPA distally to the SVC and Dacron graft anastomosis. Circulatory support of IVC flow alone increased the systemic cardiac output significantly, both with and without banding, indicating the feasibility of mechanical support of the Fontan circulation by increasing the flow only in the inferior vena cava. The increase in SVC pressure remained within acceptable limits, indicating the potential effectiveness of this mode of support. The findings suggest that increasing the flow only in the inferior vena cava is a feasible method for mechanical support of the Fontan circulation, potentially leading to an increase in cardiac output with acceptable increases in superior vena cava pressure.
Integrin β3 Reprogramming Stemness in HER2-Positive Breast Cancer Cell Lines
Authors: Boz Er Asiye
Published: June 2024

HER2-positive breast cancer, characterised by overexpressed HER2 levels, is associated with aggressive tumour behaviour and poor prognosis. Trastuzumab is a standard treatment; however, approximately 50% of patients develop resistance within one year. This study investigates the role of ITGβ3 in promoting stemness and resistance in HER2-positive breast cancer cell lines (HCC1954 and SKBR3). The findings demonstrate that chronic exposure to trastuzumab upregulates stem cell markers (SOX2, OCT4, KLF4, NANOG, SALL4, ALDH, BMI1, Nestin, Musashi 1, TIM3, CXCR4). Given the documented role of RGD-binding integrins in drug resistance and stemness, we specifically investigated their impact on resistant cells. Overexpression of ITGβ3 enhances the expression of these stem cell markers, while silencing ITGβ3 reduces their expression, suggesting a major role for ITGβ3 in maintaining stemness and resistance. Further analysis reveals that ITGβ3 activates the Notch signalling pathway, known for regulating stem cell maintenance. The combination of trastuzumab and cilengitide, an integrin inhibitor, significantly decreases the expression of stem cell markers in resistant cells, indicating a potential therapeutic strategy to overcome resistance. These results identify the importance of ITGβ3 in mediating stemness and trastuzumab resistance through Notch signalling in HER2-positive breast cancer, offering new approaches for enhancing treatment efficacy.
TAFRO Syndrome and COVID-19
Authors: Tane Misato , Kosako Hideki , Sonoki Takashi , Hosoi Hiroki
Published: June 2024

TAFRO syndrome is a systemic inflammatory disease characterized by thrombocytopenia and anasarca. It results from hyperinflammation and produces severe cytokine storms. Severe acute respiratory syndrome coronavirus 2, which led to the coronavirus disease 2019 (COVID-19) pandemic, also causes cytokine storms. COVID-19 was reported to be associated with various immune-related manifestations, including multisystem inflammatory syndrome, hemophagocytic syndrome, vasculitis, and immune thrombocytopenia. Although the pathogenesis and complications of COVID-19 have not been fully elucidated, the pathogeneses of excessive immunoreaction after COVID-19 and TAFRO syndrome both involve cytokine storms. Since the COVID-19 pandemic, there have been a few case reports about the onset of TAFRO syndrome after COVID-19 or COVID-19 vaccination. Castleman disease also presents with excessive cytokine production. We reviewed the literature about the association between TAFRO syndrome or Castleman disease and COVID-19 or vaccination against it. While the similarities and differences between the pathogeneses of TAFRO syndrome and COVID-19 have not been investigated previously, the cytokines and genetic factors associated with TAFRO syndrome and COVID-19 were reviewed by examining case reports. Investigation of TAFRO-like manifestations after COVID-19 or vaccination against COVID-19 may contribute to understanding the pathogenesis of TAFRO syndrome.
N-acetyltransferase Gene Variants Involved in Pediatric Idiosyncratic Drug-Induced Liver Injury
Authors: Alés-Palmer María Luisa , Andújar-Vera Francisco , Iglesias-Baena Iván , Muñoz-de-Rueda Paloma , Ocete-Hita Esther
Published: June 2024

Idiosyncratic drug-induced liver injury (DILI) is a complex multifactorial disease in which the toxic potential of the drug, together with genetic and acquired factors and deficiencies in adaptive processes, which limit the extent of damage, may determine susceptibility and make individuals unique in their development of hepatotoxicity. In our study, we sequenced the exomes of 43 pediatric patients diagnosed with DILI to identify important gene variations associated with this pathology. The result showed the presence of two variations in the NAT2 gene: c.590G>A (p.Arg197Gln) and c.341T>C (p.Ile114Thr). These variations could be found separately or together in 41 of the 43 patients studied. The presence of these variations as a risk factor for DILI could confirm the importance of the acetylation pathway in drug metabolism.
Efficacy and Safety of Atezolizumab as a PD-L1 Inhibitor in the Treatment of Cervical Cancer: A Systematic Review
Authors: Velimirovici Milan Daniel , Feier Catalin Vladut Ionut , Vonica Razvan Constantin , Faur Alaviana Monique , Muntean Calin
Published: June 2024

Background and objectives: The efficacy and safety of PD-L1 inhibitors in the treatment of cervical cancer is an ongoing research question. This review aims to establish a clear profile of atezolizumab, examining its impact on survival outcomes, response rates, and safety measured by serious adverse events (SAEs). Materials and methods: A literature search was conducted using PubMed, Scopus, and Web of Science, focusing on articles published up to February 2024. The review followed the PRISMA guidelines and synthesized outcomes from four randomized trial studies involving atezolizumab administered at 1200 mg IV every three weeks, alone or in combination with chemoradiotherapy. Results: A total of 284 patients received atezolizumab, the majority being advanced stage cervical cancer (IVA-IVB). Median follow-up times ranged from 9 weeks to 32.9 months. It was found that combining atezolizumab with standard therapies extended median progression-free survival (PFS) from 10.4 to 13.7 months and overall survival (OS) from 22.8 to 32.1 months, according to the phase III trial. Monotherapy and initial treatment settings with atezolizumab also showed promising efficacy, with disease-free survival rates at 24 months reaching 79% compared to 52% with standard therapy alone. However, the treatment was associated with high rates of SAEs, reaching up to 79% in more intensive treatment combinations. Conclusions: Atezolizumab demonstrates significant potential in improving PFS and OS in patients with cervical cancer, supporting its inclusion as a first-line treatment option. Despite the efficacy benefits, the high incidence of SAEs necessitates careful patient selection and management strategies to mitigate risks. This systematic review supports the continued evaluation of atezolizumab in broader clinical trials to refine its therapeutic profile and safety measures in the context of cervical cancer treatment.
Mitochondrial Dysfunction in Sporadic Amyotrophic Lateral Sclerosis Patients: Insights from High-Resolution Respirometry
Authors: Parvanovova Petra , Evinova Andrea , Grofik Milan , Hnilicova Petra , Tatarkova Zuzana , Turcanova-Koprusakova Monika
Published: June 2024

Amyotrophic lateral sclerosis is a severe neurodegenerative disease whose exact cause is still unclear. Currently, research attention is turning to the mitochondrion as a critical organelle of energy metabolism. Current knowledge is sufficient to confirm the involvement of the mitochondria in the pathophysiology of the disease, since the mitochondria are involved in many processes in the cell; however, the exact mechanism of involvement is still unclear. We used peripheral blood mononuclear cells isolated from whole fresh blood from patients with amyotrophic lateral sclerosis for measurement and matched an age- and sex-matched set of healthy subjects. The group of patients consisted of patients examined and diagnosed at the neurological clinic of the University Hospital Martin. The set of controls consisted of healthy individuals who were actively searched, and controls were selected on the basis of age and sex. The group consisted of 26 patients with sporadic forms of ALS (13 women, 13 men), diagnosed based on the definitive criteria of El Escorial. The average age of patients was 54 years, and the average age of healthy controls was 56 years. We used a high-resolution O2K respirometry method, Oxygraph-2k, to measure mitochondrial respiration. Basal respiration was lower in patients by 29.48%, pyruvate-stimulated respiration (respiratory chain complex I) was lower by 29.26%, and maximal respiratory capacity was lower by 28.15%. The decrease in succinate-stimulated respiration (respiratory chain complex II) was 26.91%. Our data confirm changes in mitochondrial respiration in ALS patients, manifested by the reduced function of complex I and complex II of the respiratory chain. These defects are severe enough to confirm this disease’s hypothesized mitochondrial damage. Therefore, research interest in the future should be directed towards a deeper understanding of the involvement of mitochondria and respiratory complexes in the pathophysiology of the disease. This understanding could develop new biomarkers in diagnostics and subsequent therapeutic interventions.
Imiquimod Reverses Chronic Toxoplasmosis-Associated Behavioral and Neurocognitive Anomalies in a Rat Model
Authors: Itani Shaymaa , Hamie Maguy , El Jammal Reem , Abdine Wassim , Doumit Mark , Charafeddine Adib , El-Sabban Marwan , Patinote Cindy , Masquefa Carine , Bonnet Pierre-Antoine , Obeid Makram , El Hajj Hiba
Published: June 2024

Toxoplasma gondii is the etiologic agent of toxoplasmosis, a highly prevalent parasitosis. Toxoplasma gondii (T. gondii) transits in the brain from acute (AT) to chronic toxoplasmosis (CT), under host immune control. In immunocompromised patients, reactivation of CT is potentially life-threatening. Behavioral and neurological complications have been associated with CT. Furthermore, an effective treatment targeting CT is still lacking. We previously reported the efficacy of imiquimod against CT. Here, we demonstrate the molecular effects of imiquimod or imiquimod followed by the clinically used combination of sulfadiazine and pyrimethamine (SDZ + PYR) on CT-associated behavior in a rat model. Imiquimod decreased the number of cysts in the brains of chronically infected rats due to an induced reactivation of bradyzoites into tachyzoites. Importantly, this decrease was more pronounced in rats treated with imiquimod followed by SDZ + PYR. Rats chronically infected with T. gondii exhibited an anxiety-like behavior. Notably, treatment with imiquimod reversed this behavior aberrancy, with even a more pronounced effect with imiquimod followed by SDZ/PYR. Similarly, rats chronically infected with T. gondii exhibited learning deficits, and imiquimod alone or followed by SDZ/PYR reversed this behavior. Our results enhance our knowledge of the implications of CT on behavioral aberrancies and highlight the potency of imiquimod followed by SDZ + PYR on these CT-associated complications.
Mitigating Job Burnout in Jordanian Public Healthcare: The Interplay between Ethical Leadership, Organizational Climate, and Role Overload
Authors: Al’Ararah Kayed , Çağlar Dilber , Aljuhmani Hasan Yousef
Published: June 2024

In today’s dynamic organizational landscape, characterized by rapid technological advancements and evolving workplace dynamics, understanding the factors influencing employee well-being is paramount. This study investigates the interplay between ethical leadership, organizational climate, role overload, and job burnout in public healthcare organizations across northern Jordan. By focusing on ethical leadership, organizational climate, and role overload as determinants of job burnout, this research provides insights into strategies for enhancing employee well-being. Drawing on ethical leadership theory, social exchange theory, and the job demands–resources model, this study employs PLS-SEM to analyze data collected from 260 employees working in Jordanian government hospitals. The findings reveal negative associations between ethical leadership and job burnout, highlighting the importance of ethical leadership behaviors in mitigating employee burnout. Additionally, a positive organizational climate is associated with lower levels of burnout, underscoring the impact of the broader organizational context on employee well-being. The study also explores the mediating role of organizational climate and the moderating effect of role overload in the relationship between ethical leadership and job burnout, providing insights into the complex dynamics at play in healthcare organizations. These findings enrich our understanding of the factors influencing employee well-being in healthcare contexts and underscore the importance of fostering ethical leadership and supportive organizational climates to mitigate job burnout.
Urban Safety, Socio-Technical Solutions for Urban Infrastructure: Case Studies
Authors: Nicolini Elvira
Published: June 2024

Urban space’s physical and environmental characteristics impact urban public safety. Specifically, many areas in the older urban core are morphologically unsafe. The historic city’s resilience to natural disasters and emergency phenomena often surpasses expectations thanks to settlement principles, post-disaster transformations, and redundancies that enhance the performance of the historic built environment. Yet, the necessity to introduce new qualities to reclaim urban heritages scattered throughout the territory, often abandoned or sparsely populated, underscores the need for maintenance and management measures to boost safety and resilience. This study aims to identify technological components in urban space that influence the safety of places and define a design method for safety planning in historic urban settings. Urban safety interventions encompass various technological aspects in conjunction with the widespread distribution of equipment, adaptation of public and private facilities, and networked infrastructure and services. This paper delineates the elements that converge in the technological design of an appropriate historic town center to address potential emergencies. It presents the initial findings of studies conducted on a minor center with a strong historical value. This document aims to be useful for administrations of smaller municipalities, as the proposed method can be replicated in similar contexts.
Predicted Corrosion Performance of Organofunctional Silane Coated Steel Reinforcement for Concrete Structures: An Overview
Authors: Pokorný Petr , Kouřil Milan
Published: June 2024

This article provides a comprehensive overview of the potential use of organofunctional silane coatings in the corrosion protection of concrete reinforcement in close relation to other commercially used coating technologies—i.e., epoxy coatings and bath hot-dip galvanizing coatings. The application technology of the steel surface is described in detail, and the corrosion performance and bond strength in concrete are compared. The paper also points out the possibility of improving the durability of epoxy coatings by the addition of silanes and, in the case of application to the surface of hot-dip galvanized steel, they can prevent corrosion of the coating by hydrogen evolution. The application potential of organofunctional silanes is also presented in the form of hydrophobic coatings on concrete surfaces or as corrosion inhibitors in simulated concrete pore solutions. The use of a suitable type of modified silane coating on the surface of carbon steel reinforcement can increase the corrosion performance and can also increase the bond strength in concrete. However, these facts need to be experimentally verified.
Evaluation Methods and Influence Factors of Blisters Disease in Concrete Composite Bridges
Authors: Yu Chen , Zhang Mengya
Published: June 2024

The decks of steel–concrete composite bridges are constantly exposed to severe environmental conditions, which frequently give rise to significant issues, including cracks and holes. These problems occur due to the formation of blisters under the paving layer with waterproofing membranes. This paper aims to delve into the characteristics of blisters during their expansion and propagation stages. Additionally, it proposes a rating index and a simplified calculation formula to assess the interface propagation performance of bridge deck pavement. To achieve this, the research group developed a simulated blister test device and employed the digital image correlation (DIC) technique. The study investigated the impact of pavement structure, waterproofing layer, and air voids on blister propagation behavior. It was discovered that the pavement blister test encompassed two distinct stages: expansion and propagation. Furthermore, the SMA-13 asphalt mixture exhibited slightly superior resistance to blistering compared to AC-13. It was also observed that when the mixture void ratio is less than 3.5%, it becomes more susceptible to blistering deformation, ultimately leading to debonding damage. Among the waterproofing materials tested, SBS-modified emulsified asphalt demonstrated the weakest adhesion to cement concrete substrates, while SBS-modified asphalt performed slightly better than rubberized asphalt.
Development of a Compartment Model to Study the Pharmacokinetics of Medical THC after Oral Administration
Authors: Mahahong Thanachok , Saleewong Teerapol
Published: June 2024

The therapeutic potential of delta9-tetrahydrocannabinol (THC), a primary cannabinoid in the cannabis plant, has led to its development into oral medical products for treating various conditions. However, THC, being a psychoactive substance, can lead to addiction if taken in inappropriate amounts. Thus, studying the pharmacokinetics of THC is crucial for understanding how the drug behaves in the body after administration. This study aims to develop a multi-compartmental model to investigate the pharmacokinetics of medical THC and its metabolites after oral administration. Using the law of mass action, the model was converted into ordinary differential equations (ODEs) to describe the rate of concentration changes of THC and its metabolites in each compartment. The nonstandard finite difference (NSFD) method was then applied to construct numerical solution schemes, which were implemented in MATLAB along with estimated pharmacokinetic rate constants. The results demonstrate that the simulation curves depicting the plasma concentration–time profiles of THC and 11-hydroxy-THC (THC-OH) closely resemble actual data samples, indicating the model’s accuracy. Moreover, the model predicts the pharmacokinetics of THC and its metabolites in various tissues. Consequently, this model serves as a valuable tool for enhancing our understanding of the pharmacokinetics of THC and its metabolites, guiding dosage adjustments, and determining administration durations for oral medical THC.
InfoSTGCAN: An Information-Maximizing Spatial-Temporal Graph Convolutional Attention Network for Heterogeneous Human Trajectory Prediction
Authors: Ruan Kangrui , Di Xuan
Published: June 2024

Predicting the future trajectories of multiple interacting pedestrians within a scene has increasingly gained importance in various fields, e.g., autonomous driving, human–robot interaction, and so on. The complexity of this problem is heightened due to the social dynamics among different pedestrians and their heterogeneous implicit preferences. In this paper, we present Information Maximizing Spatial-Temporal Graph Convolutional Attention Network (InfoSTGCAN), which takes into account both pedestrian interactions and heterogeneous behavior choice modeling. To effectively capture the complex interactions among pedestrians, we integrate spatial-temporal graph convolution and spatial-temporal graph attention. For grasping the heterogeneity in pedestrians’ behavior choices, our model goes a step further by learning to predict an individual-level latent code for each pedestrian. Each latent code represents a distinct pattern of movement choice. Finally, based on the observed historical trajectory and the learned latent code, the proposed method is trained to cover the ground-truth future trajectory of this pedestrian with a bi-variate Gaussian distribution. We evaluate the proposed method through a comprehensive list of experiments and demonstrate that our method outperforms all baseline methods on the commonly used metrics, Average Displacement Error and Final Displacement Error. Notably, visualizations of the generated trajectories reveal our method’s capacity to handle different scenarios.
Institutional Quality and Internationalization: Empirical Evidence from Manufacturing SMEs in Vietnam
Authors: Ho Bao Dinh , Nguyen Tung
Published: June 2024

This paper assesses how the local institutional environment affects the internationalization of manufacturing small- and medium-sized enterprises (SMEs) in Vietnam, exploiting a multi-dimensional institutional index and large-scale enterprise data. The authors find that the internationalization of manufacturing SMEs was influenced by several institutional aspects, such as the transparency of local authorities, access to land, informal charges, and local labor policies. Improvements in these institutional aspects can substantially enhance participation in international trade and its magnitude. This pattern diverges from their large and foreign counterparts, whose trade participation is primarily affected by land access and the transparency of local authorities. Additionally, the authors find heterogeneous effects of the institutional environment on SMEs in different manufacturing industries. Heavy industries rely more on the costs of entry and time costs, while land access is crucial for SMEs in manufacturing industries that require large-sized factories. Our findings suggest that the government should provide a supportive institutional environment to SMEs, which will lead to higher international participation and boost domestic economic growth.
Should Monetary Policy in South Africa Lean against the Wind by Targeting the Financial Cycle?
Authors: Nyati Malibongwe Cyprian
Published: June 2024

Recently, several studies have argued about the interactions of the real economy and financial system, as well as the importance of financial cycles in business cycle fluctuations. To date, there exists near consensus among central bankers, economists, and other scholars that the financial cycle is an important source of business cycle fluctuations. This has raised the question of whether monetary policy should respond to financial instability and/or imbalances. As a result, we asked the following questions: Should monetary policy lean against the wind by targeting the aggregate financial cycle in South Africa? And what is the role of monetary policy in minimizing financial imbalances and instabilities in South Africa? The present article aims to provide answers to the above-mentioned question. Through the adoption of a multiple-equation generalized method of moments and structural vector autoregressive approaches, this article simultaneously estimates and compares both the finance-augmented and the conventional Taylor rules. It is shown that the South African Reserve Bank has considered developments in the aggregate financial cycle in setting its policy rate. Overall, there is clear evidence to conclude that the South African Reserve Bank can lean against the wind by targeting the aggregate financial cycle, but only as a genuine augmentation not as a fully flagged objective. This article adds new evidence to the South African literature on the prevailing debate of whether monetary policy should respond to developments in the financial system.
Study Abroad at Home: The Impact of a Multilingual and Multicultural Classroom Experience on Non-Native Medical Students’ English Language Skills Development
Authors: Németh Timea , Marek Erika , Sütő Balázs , Hild Gabriella
Published: June 2024

Study Abroad programs yield substantial linguistic advantages in addition to fostering academic and intercultural enrichment. Nevertheless, some students miss these programs due to financial constraints, academic commitments, or insufficient language skills. This paper reports the findings of a qualitative action research study that seeks to evaluate the impact of a multilingual and multicultural class, designed as a quasi-Study Abroad experience, on Hungarian medical students’ perceived English linguistic development by the end of the semester. Semi-structured focus group interviews were carried out with 42 Hungarian medical students at the end of the spring and autumn semesters of the 2021–2022 and the 2022–2023 academic years. The outcomes of the focus-group interviews indicated that the students had a positive experience studying in a multilingual and multicultural environment; their willingness to engage in English communication, along with an increase in self-confidence, was apparent, ultimately showcasing improved perceived proficiency in English communication skills by the end of the term. Creating an educational setting abundant in linguistic and cultural diversity and integrating multicultural project-based learning activities within the curriculum to simulate a quasi-Study Abroad experience represent methodological frameworks that could serve as pivotal models for shaping similar courses in the future.
How Do Nature-Based Outdoor Learning Environments Affect Preschoolers’ STEAM Concept Formation? A Scoping Review
Authors: Trina Nazia Afrin , Monsur Muntazar , Cosco Nilda , Shine Stephanie , Loon Leehu , Mastergeorge Ann
Published: June 2024

This scoping review examined the impact of nature-based outdoor learning environments on the formation of STEAM (science, technology, engineering, arts, and mathematics) concepts in preschoolers. Preschool age (3–5 years) is the time when physical interaction with surrounding built environments increases, and spontaneous learning from the environment intensifies—making it an ideal age range to promote nature-based informal learning. An outdoor learning environment can influence STEAM concept formations of preschoolers with an intentional design that offers STEAM learning affordances. Despite the rising interest in early STEAM education, there is still limited literature on how the outdoor environment may influence STEAM learning behaviors of preschoolers (3–5 years old). This scoping review intended to evaluate the existing knowledge regarding the physical factors contributing to STEAM learning affordances in an outdoor environment for children aged three to five. The review included studies from the last twenty years. This scoping review was conducted following the criteria outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). For this scoping review, 843 citations were discovered across four databases (JSTOR, Scopus, EBSCOhost, and Web of Science), ProQuest, and Google Scholar, and 31 articles were considered eligible for inclusion. The paper synthesized those 31 studies to identify the key STEAM learning behaviors of children and STEAM-activity-supportive settings that may positively influence preschoolers’ STEAM concept development.
Improving Single-Image Super-Resolution with Dilated Attention
Authors: Zhang Xinyu , Cheng Boyuan , Yang Xiaosong , Xiao Zhidong , Zhang Jianjun , You Lihua
Published: June 2024

Single-image super-resolution (SISR) techniques have become a vital tool for improving image quality and clarity in the rapidly evolving field of digital imaging. Convolutional neural network (CNN) and transformer-based SISR techniques are very popular. However, CNN-based techniques are not suitable when capturing long-range dependencies, and transformer-based techniques suffer from computational complexity. To tackle these problems, this paper proposes a novel method called dilated attention-based single-image super-resolution (DAIR). It comprises three components: low-level feature extraction, multi-scale dilated transformer block (MDTB), and high-quality image reconstruction. A convolutional layer is used to extract the base features from low-resolution images, which lays the foundation for subsequent processing. Dilated attention is introduced to MDTB to enhance its ability to capture image features at different scales and ensure superior image details and structure recovery. After that, MDTB refines these features to extract multi-scale global attributes and effectively grasps images’ long-distance relationships and features across multiple scales. Finally, low-level features obtained from feature extraction and multi-scale global features obtained from MDTB are aggregated to reconstruct high-resolution images. The comparison with existing methods validates the efficacy of the proposed method and demonstrates its advantage in improving image resolution and quality.
A Review on Electrochemical Advanced Oxidation Treatment of Dairy Wastewater
Authors: Das Ashish Kumar , Chen Lide
Published: June 2024

Dairy wastewater (DW) contains a high concentration of organic and inorganic pollutants. In recent years, extensive research has been conducted to develop more efficient techniques for the treatment of DW. Electrochemical advanced oxidation processes (EAOPs) have gained significant attention among the various treatment approaches. EAOPs rely on electrochemical generation of hydroxyl radicals (•OH) which are considered highly potent oxidizing compounds for the degradation of pollutants in DW. In this paper, we provide an overview of the treatment of DW using various EAOPs, including anodic oxidation (AO), electro-Fenton (EF), photo electro-Fenton (PEF), and solar photo electro-Fenton (SPEF) processes, both individually and in combination with other techniques. Additionally, we discuss the reactor design and operating parameters employed in EAOPs. The variation in degradation efficiency is due to different oxidizing agents produced in specific approaches and their pollutant degradation abilities. In AO process, •OH radicals generated on electrode surfaces are influenced by electrode material and current density, while EF procedures use Fe2+ to create oxidizing agents both on electrodes and in the DW solution, with degradation mechanisms being affected by Fe2+, pH, and current density; additionally, PEF and SPEF approaches enhance oxidizing component production and pollutant degradation using ultraviolet (UV) light. Integration of EAOPs with other biological processes can enhance the pollutant removal efficiency of the treatment system. There is a scope of further research to exhibit the effectiveness of EAOPs for DW treatment in large scale implementation.
Exploring Phenotype, Genotype, and the Production of Promising GABA Postbiotics by Lactiplantibacillus plantarum: A Comprehensive Investigation
Authors: Abdel-motaal Heba , Abdelazez Amro , Wang Peikun , Abady Ghada , Abozaed Shaima , Ye Bin , Xu Linan , Zhao Yuzhong , Niu Jianrui , Alshehry Garsa , Algarni Eman , Aljumayi Huda , Zhang Xinglin
Published: June 2024

This study aims to investigate the probiotic properties of various isolated strains of Lactiplantibacillus plantarum. Specifically, the focus is on examining the expression of the glutamic acid decarboxylase (GAD) gene and its role in the production of gamma-aminobutyric acid (GABA), a promising postbiotic metabolite. The investigation includes comprehensive analyses of morphology, genetics, resilience against bile, NaCl, and simulated pancreatin juice (SPJ), carbohydrate fermentation patterns, antibacterial activity, susceptibility to antibiotics, and the presence of β-D-galactosidase and GAD enzymes. Six L. plantarum strains exhibited remarkable resilience against bile, NaCl, and SPJ, as well as susceptibility to antibiotics and antagonistic behavior against pathogens. These strains also showed the presence of β-D-galactosidase. Additionally, five L. plantarum strains were found to harbor the gad gene. Further biochemical analysis of four specific L. plantarum strains revealed promising profiles consisting of antibiotics, vitamins, hormones, and a diverse array of metabolites with potential immunotherapeutic properties. This study highlights the substantial potential of Lactiplantibacillus plantarum in generating beneficial postbiotic metabolites. The identified strains offer exciting avenues for further exploration, with potential applications in functional foods and pharmaceuticals. This research opens up possibilities for harnessing the probiotic and postbiotic potential of L. plantarum to develop novel products with health-promoting properties.
Studies on the Properties and Stability Mechanism of Double Emulsion Gels Prepared by Heat-Induced Aggregates of Egg White Protein-Oligosaccharides Glycosylation Products
Authors: Zhao Qianwen , Lu Cheng , Chang Cuihua , Gu Luping , Li Junhua , Guo Lulu , Hu Shende , Huang Zijian , Yang Yanjun , Su Yujie
Published: June 2024

Multiple emulsions can dissolve some substances with different properties, such as hydrophilicity and lipophilicity, into different phases. They play an important role in protection, controlled release and targeted release of the encapsulated substances. However, it’s poor stability has always been one of the main problems restricting its application in the food industry. For this reason, a heat-induced aggregate (HIA) of Maillard graft product of isomalto-oligosaccharides (IMO), as well as egg white protein (EWP), was used as hydrophilic emulsifier to improve the stability of W1/O/W2 emulsions. Moreover, gelatin was added into the internal aqueous phase (W1) to construct W1/O/W2 emulsion-gels system. The encapsulation efficiency of HIA-stabilized W1/O/W2 emulsions remained nearly unaltered, dropping by only 0.86%, significantly outperforming the conjugates and physical mixture of IMO and EWP in terms of encapsulation stability. The emulsion-gels system was constructed by adding 5% gelatin in the W1, and had the highest EE% and good salt and heat stability after 30 days of storage. This experiment provides guidance for improving the stability of W1/O/W2 emulsions system and its application in the package delivery of functional substances in the food field.
Printability and Thermophysical Properties of Three-Dimensional-Printed Food Based on “Cochayuyo” Durvillaea antarctica Seaweed Flour
Authors: Lemus-Mondaca Roberto , Puente-Díaz Luis , Vásquez-Montaño Alonso , León Emilson , Zura-Bravo Liliana , Ortiz-Viedma Jaime
Published: June 2024

This research assessed the feasibility of adding Cochayuyo seaweed flour (at 30, 50, and 70% levels) to rice flour-based paste to improve its 3D printing quality. The paste’s rheological properties, printing quality, texture profile, thermal properties, and color of 3D-printed foods were explored. Results showed that pastes with Cochayuyo addition exhibited shear-thinning behavior, and viscosity increased with increased Cochayuyo concentration. Viscoelastic properties and a Texture Profile Analysis (TPA) revealed that Cochayuyo improved mechanical strength and made the paste easier to flow, improving printed food’s extrudability, fidelity, and shape retention, which was better observed in RC50 and RC70 printed at 15 mm s−1. A differential scanning calorimetry (DSC) analysis showed a partial substitution of rice flour for Cochayuyo flour in the formulation. This increased the onset and melting peak temperatures and reduced the enthalpy of fusion. CIE color parameters a*, b*, and L* showed that Cochayuyo addition increased the color to yellow and red; however, lightness was considerably reduced. Therefore, Cochayuyo flour could have the potential to be used for the manufacture improvement of 3D-printed food with better rheological, mechanical, thermal, printing quality, and nutritional properties, making possible the exploitation of the native Cochayuyo seaweed, which is highly available in Chile.
The Impact of the Fresh Pork Display Lamps on the Sensory Response of Consumers to Fresh Pork
Authors: Liu Yixuan , Chen Wei , Wu Xinwei , Pointer Michael , Chen Zhengjie , Liu Xinghai , Liu Qiang , Xie Xufen
Published: June 2024

Two studies were conducted to investigate the impact of fresh pork display lamps on consumers’ sensory responses to pork products. In the first experiment, 63 participants were asked to evaluate pork products with different degrees of freshness under four fresh pork display lights and two LED lights. In the other experiment, 30 subjects participated in the Farnsworth–Munsell 100 hue test under the same lamps, with the aim of showing whether the fresh pork display lamps impaired color discrimination. The results showed that the light source had a significant effect on the color appearance evaluation of the pork products. The ratings for perceived freshness under the fresh pork display lamps were significantly higher than those of ordinary LED lamps, while the color discrimination performance of the subjects under those lamps was poor. It was demonstrated that improper component proportions of the light spectrum could influence observers’ assessment of meat quality and weaken the observers’ ability to distinguish the freshness level. Through this study, the authors would like to remind lamp users and manufacturers to not only be concerned about the improvement in the color appearance of pork, but also the need for consumers to be aware of the authentic freshness of the pork products.