bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS MINAT MASYARAKAT UNTUK INVESTASI EMAS DI PEGADAIAN
Authors: Ramadhan Faessal Ilham , Aminullah Achmad Muttaqin
Published: October 2024

The purpose of this study is to assess the community's interest in gold investment through the services offered by Pegadaian Blitar and to understand the performance achievements of Pegadaian Blitar regarding its gold investment products. This research focuses on various factors that influence individuals to engage in gold investment activities at Pegadaian Blitar. Consequently, the researcher needs to conduct in-depth observations regarding the ongoing phenomena within the community itself. Employing a qualitative method, this study aims to gain a profound understanding of the phenomena occurring at Pegadaian. Findings from this research indicate that the Blitar community has an interest in gold investment at Pegadaian, facilitated by gold savings products that assist individuals in investing. The community is motivated to secure their future, and Pegadaian has been relatively successful in promoting its products. However, Pegadaian still needs to educate the community further about the importance of investment so that they become more interested in investing.
Identifying Structural Damage in Steel Truss Frames Using Computer-Based Numerical Simulation with the Second Order Blind Identification (SOBI) Method
Authors:   Civil Engineering Department, Jayapura University of Science and Technology, 99352, Indonesia, Haurissa Ryan
Published: October 2024

The failure of the building work is due to the structure failing to function and can also cause material losses and can even cause fatalities. Because of that, excellent and careful anticipation is needed. In this regard, the re-search that will be carried out is monitoring the structure's health by identifying structural damage based on vi-bration tests. Modal structural parameters are determined based on the vibration output using the Second Order Blind Identification algorithm created by numerical simulation in the MATLAB application. The method in this research is a laboratory experiment with two testing models, namely the modal parameter values of the typical truss structure and the damaged truss structure, using the Second Order Blind Identification algorithm method. Furthermore, analyzing the indications of structural damage from the estimated modal parameters, the accuser, and the effectiveness of the Second Order Blind Identification algorithm method is feasible to use. The results showed that the Hp sensor recording data that had been processed were the health15mts.mat and dam-age15mts.mat files loaded into the SOBI program, and the predicted value of the natural frequency of typical structures was 31,9072 rad/s, and damaged structures were 22,6089 rad/s. From the expected frequency, the frequency ratio value is 41.127 %. According to the Steel Frame Bridge Inspection Regulation No.005/BM/2009 Guidelines for Construction and Building of the Ministry of Public Works, Directorate General of Highways, if it exceeds 20%, it can be categorized as critical.
Prediction of Creep Concrete in Lightweight Concrete with Pumice as Coarse Aggregate
Authors:   Department of Civil Engineering, Universitas Brawijaya, 65145, Indonesia, Maulidyah Chairah , Wisnumurti Wisnumurti ,   Department of Civil Engineering, Universitas Brawijaya, 65145, Indonesia, Setyowulan Desy ,   Department of Civil Engineering, Universitas Brawijaya, 65145, Indonesia
Published: October 2024

Concrete creep is the additional strain that develops in concrete under constant stress over time. In this study, lightweight concrete is created by entirely replacing coarse aggregate with pumice to reduce the concrete's overall weight. The research involves producing 18 cylindrical concrete test specimens with a diameter of 150mm and a height of 300mm. These specimens include three normal and three lightweight concrete samples for each 90-day creep test and three normal and three lightweight concrete samples for compressive strength tests on the 14th and 28th days. The variation in aggregate proportions affects the aggregate content and weight in each type of concrete, influencing their properties. This is evident in the creep curves for the lightweight concrete samples. Similarly, the differences in the creep curves for normal concrete samples are attributed to stress distribution during loading. The strain acceleration between normal and lightweight concrete under load remains similar until the final loading day at 90 days. However, lightweight concrete significantly increases creep value after prolonged loading, rising by 35.85%. In contrast, normal concrete exhibits a creep increase of 16.51% from the beginning of loading until the 90th day.
Results from the Curat Sonification Game
Authors: Ziemer Tim
Published: October 2024

In 2020, we released the CURAT sonification game, a multi- platform game for the remote evaluation of our three-dimensional psychoacoustic sonification. In this paper, we present an evaluation of the initial results. These indicate that gamification is a reliable means for the remote evaluation of sonification. But the game should be kept simplistic, as many players only play the default modes. The performance results are comparable to results from laboratory experiments and underline that interaction tremendously improves the precision with which users can interpret the sonification.
Influence of Recording Technique and Ensemble Size on Apparent Source Width
Authors: Guo Renzhi , Braasch Jonas
Published: October 2024

Previous studies have looked at how different concert halls with different lateral reflections affect apparent source width. Yet, the perceptual effects of different source distributions with different recording techniques on apparent source width are not well understood. This study explores how listeners perceive the width of an orchestra by using four stereo and one binaural recording techniques and three wave field synthesis ensemble settings. Subjective experiments were conducted using stereo loudspeakers and headphone to play back the recording clips asking the listeners to rate the perceived wideness of the sound source. Results show that recording techniques greatly influence how wide an orchestra is perceived. The primary mechanism used to judge auditory spa- tial impression differs between stereo loudspeaker and headphone listening. When western classical symphony is recorded and reproduced by two-channel stereophony, the changes in instrument positions in terms of increasing or reducing the physical source width do not lead to an obvious increase or reduction on the spatial impression of the performing entity.
Brightness Is More Efficient Than Delay to Induce Weight Perception in Augmented Reality
Authors: Lafuma Louis , Bouyer Guillaume , Didier Jean-Yves , Goguel Olivier
Published: October 2024

Multimodal feedback is used to convey various and rich informa- tion in virtual environments. It can also change users’ perceptions of the haptic properties of objects through the pseudo-haptic illusion. While visual feedback has been extensively examined to induce haptic properties like weight in virtual reality, only a handful of studies have explored the use of audio feedback, and even fewer in augmented reality. Our study aims to extend, in an augmented reality context, previous research findings that used sound to enhance the weight perception of virtual objects. Participants were asked to grab two objects that produced sounds with different audio delays and brightness and to determine which of the two was heavier. The results on 38 participants showed that while the delay did not affect weight perception, the brightness did have a significant impact. This is in line with previous studies and could be used to enhance the perception of hand interactions in AR.
Composing Music from Black Hole AGN Spectra
Authors: Ibbett David
Published: October 2024

Black Hole Symphony is an audiovisual symphony touring planetariums and science centers across the US, with the goal of communicating the richness of science to a wide audience. Composed in 5 movements, the composition is derived from a single harmonic structure: a sonification of the electromagnetic emissions from a black hole's Active Galactic Nucleus (AGN). Originating from a complex 3- dimensional structure of dust and gas, these emissions span the entire electromagnetic spectrum - a range of >20 orders of magnitude or 60 octaves - and thus far exceed the frequency span of our eyes. In this paper, I will discuss my development of spectral audification methods, their application for creating the Black Hole Chord, and how this harmonic structure gives rise to the galaxy of themes and movements that make up Black Hole Symphony.
Categorization of mHealth Coaching Technologies for Children or Adolescents With Type 1 Diabetes: Systematic Review
Authors: Trnka Pavel , Aldaghi Tahmineh , Muzik Jan
Published: October 2024

Background

Managing type 1 diabetes in children and adolescents can be difficult for parents, health care professionals, and even patients. However, over the last decades, the quality of services provided to patients with diabetes has increased due to advances in IT.

Objective

This study aims to comprehensively document the range of IT tools used in the management of diabetes among children and adolescents, with a focus on identifying the technologies most commonly used based on their frequency. In addition, the study aims to explore relevant methodologies for developing diabetes technology and provide valuable information to developers by delineating essential phases of the design process.

Methods

The literature search was focused on MEDLINE (PubMed), Web of Science, and Google Scholar for relevant studies. Keywords such as “type 1 diabetes,” “adolescents,” “kids,” “mHealth,” “children,” and “coaching” were combined using Boolean operators. The inclusion criteria were open access, English-language papers published between 2012 and 2023 focusing on patients younger than 18 years and aligned with our research goal. The exclusion criteria included irrelevant topics and papers older than 18 years. By applying the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method, 2080 studies were recognized, and after selection, 33 papers were agreed upon between the researchers.

Results

Four primary categories were defined: types of IT, methodology identification, purpose identification, and feature determination. Among these, mobile health (mHealth) apps emerged as the predominant type of information, garnering 27 mentions. In particular, user-centered design was identified as the most prevalent methodology, cited 22 times. The primary purpose of self-monitoring blood glucose values was mentioned 20 times, while patient education was the highest among common characteristics, with 23 mentions.

Conclusions

Based on our research, we advocate for developers to focus on creating an mHealth app that integrates gamification techniques to develop innovative diabetes management solutions. This app should include vital functionalities such as blood glucose monitoring, strategies to improve hemoglobin A1c levels, carbohydrate tracking, and comprehensive educational materials for patients and caregivers. By prioritizing these features, developers can enhance the usability and effectiveness of the technology, thereby better supporting children or adolescents with diabetes in their daily management endeavors.
Self-Guided Smartphone App (Vimbo) for the Reduction of Symptoms of Depression and Anxiety in South African Adults: Pilot Quantitative Single-Arm Study
Authors: Steyn Sherrie , Slabbert Meggan
Published: October 2024

Background

Barriers to mental health assessment and intervention have been well documented within South Africa, in both urban and rural settings. Internationally, evidence has emerged for the effectiveness of technology and, specifically, app-based mental health tools and interventions to help overcome some of these barriers. However, research on digital interventions specific to the South African context and mental health is limited.

Objective

This pilot study investigated the feasibility of using an app (Vimbo) to treat symptoms of anxiety and depression in South African adults recruited from a community sample. The Vimbo app is a self-guided, cognitive behavioral therapy–based digital intervention for common mental health difficulties developed for the South African context.

Methods

This pilot study used a naturalistic, single-arm design testing the Vimbo app over 12 weeks, from October 2020 to February 2021. Participants were recruited through the South African Depression and Anxiety Group and social media advertisements online. A 2-week retention period was used to allow for a minimum of 2 datasets. App usage and engagement metrics were extracted directly from the back end of the app. Based on the model, researchers expected many users to discontinue usage when their symptom levels entered a healthy range. Pre-post review of symptom levels was used to reflect on clinical recovery status at discontinuation after the retention period.

Results

A total of 218 applicants met study eligibility criteria and were invited to download the Vimbo app. Of these, 52% (114/218) of the participants registered with the app, who indicated multiple variances of depression and anxiety symptoms ranging in severity from mild to severe. Two participants users withdrew from the study. Moreover, 69% (77/112) of users were retained, including 8 who had technical issues with their treatment. When comparing broad uptake across all interested participants, chi-square analysis indicated significantly reduced uptake in participants identifying as “unemployed but seeking employment” (χ24=10.47; N=251; P=.03). When considering app usage for the entire cohort (n=69, excluding participants with technical issues), there was a mean of 72.87 (SD 71.425) total module pages read, a mean of 30% (SD 29.473%) of prescribed content completed, and a mean of 19.93 (SD 27.517) times engaging with tools and skills.

Conclusions

Our findings support the case for continued exploration of app-based interventions for treating depression and anxiety in South Africa. Developing strategies to increase access and improve intervention uptake may prove essential to helping mobile health interventions make as significant an impact as possible. Future research should include a randomized controlled trial with a larger sample to further assess the efficacy of app-based interventions in treating mental health difficulties in South Africa.
Age Variation Among US Adults’ Social Media Experiences and Beliefs About Who Is Responsible for Reducing Health-Related Falsehoods: Secondary Analysis of a National Survey
Authors: Galinkala Prathyusha , Atkinson Elise , Campos-Castillo Celeste
Published: October 2024

Background

We live in a digital age where social media has become an essential part of people’s lives. It is also one of the leading platforms responsible for spreading health-related falsehoods. This study explores who adults of different age groups perceive as responsible for reducing health-related falsehoods on social media.

Objective

Despite growing concern over older adults’ exposure to false health information on social media, little research examines their beliefs on how to address the problem. This study examines how the age of US adults is associated with their reported experiences with health-related falsehoods on social media and their beliefs about who should be tasked with reducing such falsehoods.

Methods

This study is a secondary analysis of data from the 2022 Health Information National Trends Survey, a nationally representative survey of US adults (18 years and older). Multivariable logistic regressions estimated how a respondent’s age was associated with their self-reported social media use, their difficulty to detect health-related falsehoods on social media, their discussion of health information found on social media with medical providers, and their beliefs regarding who should be responsible for reducing health-related falsehoods on social media. Regression estimates were adjusted for respondents’ sociodemographic and health characteristics.

Results

Daily social media use decreased with respondents’ age. Respondents aged 50‐64 years (b=0.515, P=.01) and 65‐74 years (b=0.697, P=.002) were more likely than respondents aged 18‐34 years to report they strongly agree that it is difficult for them to detect health-related falsehoods on social media. Compared to younger adults, older adults (65‐74 years: b=0.818, P=.002; 75 years and older: b=1.058, P<.001) were more likely to believe medical providers should be responsible for reducing online falsehoods.

Conclusions

In addition to ongoing efforts by social media platforms to detect and remove falsehoods, the findings suggest medical providers should be tasked with discrediting health-related falsehoods on social media for older adults. However, time during the clinical visit is limited. Future research is needed to discover new approaches and tools tailored to older adults to assist with filtering and discrediting health-related falsehoods on social media.
Extent and Nature of Television Food and Nonalcoholic Beverage Marketing in 9 Asian Countries: Cross-Sectional Study Using a Harmonized Approach
Authors: Karupaiah Tilakavati , Rahman Shah Md Mahfuzur , Zhang Juan , Kumar Naveen , Jamiyan Batjargal , Pokharel Raj Kumar , Borazon Elaine Quintana , Thoradeniya Tharanga , Tho Nguyen Thi Thi , Mackay Sally , Kelly Bridget , Swinburn Boyd , Chinna Karuthan , Dashzeveg Enkhmyagmar , Ong Gild Rick , Narayanan Sreelakshmi Sankara , Sameeha Mohd Jamil , Uddin Mohammad Ahsan , Tang Yuxiang , Sharma Naresh Kumar , Pokharel Rishav , Rome Anna Christine , Wickramasinghe V Pujitha , Huy Phan Thanh
Published: October 2024

Background

Rising childhood obesity rates in Asia are adding risk for the future adult burden of obesity and noncommunicable diseases. Weak policies across most Asian countries enable unrestricted marketing of obesogenic foods and beverages to children. Television is the common medium for food marketing to reach this audience.

Objective

This study aimed to assess the extent and nature of television food and nonalcoholic beverage marketing in 9 Asian countries (Bangladesh, China, India, Malaysia, Mongolia, Nepal, the Philippines, Sri Lanka, and Vietnam) with capacity building support from the International Network for Food and Obesity/Non-Communicable Disease Research, Monitoring and Action Support, who enabled harmonization of data collection method and content analyses.

Methods

Advertised foods were categorized as permitted or not permitted based on the nutrient profile models established by the World Health Organization regional offices for South-East Asia (SEARO) and the World Health Organization regional offices for Western Pacific (WPRO). Overall rates of food advertisements (advertisements per hour per channel) and persuasive strategy use were analyzed along with comparisons between children’s peak viewing time (PVT) and non-PVT.

Results

Cross-country comparisons, irrespective of country income level, indicated that not permitted food advertising dominated children’s popular television channels, especially during PVT with rates as per WPRO or SEARO criteria ranging from 2.40/2.29 (Malaysia) to 9.70/9.41 advertisements per hour per channel (the Philippines). Persuasive strategy rates were also comparatively higher during PVT. Sugar-sweetened beverages, sugar-containing solid foods, and high salt- and fat-containing snacks and fast foods were frequently advertised. Evaluation of the application of WPRO and SEARO nutrient profile models identified inconsistencies due to regional taste and cuisine variations across Asia.

Conclusions

This study clearly showed that unhealthy food marketing through popular children’s television channels is widely occurring in Asia and is a clear breach of child rights. Evidence outcomes will benefit advocacy toward stronger policy regulations to control unhealthy food marketing and strengthen strategies to promote a healthier food environment for Asia’s children.
Web-Based Parent Training With Telephone Coaching Aimed at Treating Child Disruptive Behaviors in a Clinical Setting During the COVID-19 Pandemic: Single-Group Study With 2-Year Follow-Up
Authors: Sourander Saana , Westerlund Minja , Baumel Amit , Hinkka-Yli-Salomäki Susanna , Ristkari Terja , Kurki Marjo , Sourander Andre
Published: October 2024

Background

There is a lack of studies examining the long-term outcomes of web-based parent training programs implemented in clinical settings during the COVID-19 pandemic.

Objective

The aim is to study 2-year outcomes of families with 3‐ to 8-year-old children referred from family counseling centers to the Finnish Strongest Families Smart Website (SFSW), which provides digital parent training with telephone coaching aimed at treating child disruptive behaviors.

Methods

Counseling centers in Helsinki identified fifty 3‐ to 8-year-old children with high levels of disruptive behavioral problems. Child psychopathology and functioning as well as parenting styles and parental mental health were collected from parents at baseline; posttreatment; and at 6-, 12-, and 24-month follow-ups.

Results

The SFSW program had positive long-term changes in child psychopathology and parenting skills. Improvements in child psychopathology, including Strengths and Difficulties Questionnaire total score (Cohen d=0.47; P<.001), Strengths and Difficulties Questionnaire conduct scores (Cohen d=0.65; P<.001), and Affective Reactivity Index irritability scores (Cohen d=0.52; P<.001), were maintained until the 24-month follow-up. Similarly, changes in parenting skills measured with the Parenting Scale, including overreactivity (Cohen d=0.41; P=.001) and laxness (Cohen d=0.26; P=.02), were maintained until the 24-month follow-up. However, parental hostility changes were not maintained at long-term follow-up (Cohen d=−0.04; P=.70).

Conclusions

The study shows that the SFSW parent training program can yield significant long-term benefits. Findings indicate that the benefits of the treatment may vary between different parenting styles, which is important to consider when developing more personalized parenting interventions.
Design of a Temporally Augmented Text Messaging Bot to Improve Adolescents’ Physical Activity and Engagement: Proof-of-Concept Study (Preprint)
Authors: Ortega Adrian , Cushing Christopher C
Published: October 2024

BACKGROUND

Digital interventions hold promise for improving physical activity in adolescents. However, a lack of empirical decision points (eg, timing of intervention prompts) is an evidence gap in the optimization of digital physical activity interventions.

OBJECTIVE

The study examined the feasibility and acceptability, as well as the technical and functional reliability, of and participant engagement with a digital intervention that aligned its decision points to occur during times when adolescents typically exercise. This study also explored the impact of the intervention on adolescents’ moderate to vigorous physical activity (MVPA) levels. Consistent with the Obesity-Related Behavioral Interventions Trials (ORBIT) model, the primary goal of the study was to identify opportunities to refine the intervention for preparation for future trials.

METHODS

Ten adolescents completed a 7-day baseline monitoring period and Temporally Augmented Goal Setting (TAGS), a 20-day digital physical activity intervention that included a midday self-monitoring message that occurred when adolescents typically start to exercise (3 PM). Participants wore an accelerometer to measure their MVPA during the intervention. Participants completed questionnaires about the acceptability of the platform. Rates of recruitment and attrition (feasibility), user and technological errors (reliability), and engagement (average number of text message responses to the midday self-monitoring message) were calculated. The investigation team performed multilevel models to explore the effect of TAGS on MVPA levels from preintervention to intervention. In addition, as exploratory analyses, participants were matched to adolescents who previously completed a similar intervention, Network Underwritten Dynamic Goals Engine (NUDGE), without the midday self-monitoring message, to explore differences in MVPA between interventions.

RESULTS

The TAGS intervention was mostly feasible, acceptable, and technically and functionally reliable. Adolescents showed adequate levels of engagement. Preintervention to intervention changes in MVPA were small (approximately a 2-minute change). Exploratory analyses revealed no greater benefit of TAGS on MVPA compared with NUDGE.

CONCLUSIONS

TAGS shows promise for future trials with additional refinements given its feasibility, acceptability, technical and functional reliability, participants’ rates of engagement, and the relative MVPA improvements. Opportunities to strengthen TAGS include reducing the burden of wearing devices and incorporating of other strategies at the 3 PM decision point. Further optimization of TAGS will inform the design of a Just-in-Time Adaptive Intervention for adolescent physical activity and prepare the intervention for more rigorous testing.
Development and Evaluation Smartphone Applications (AIL-s TB) as Educational Media to Increase Knowledge among Pulmonary Tuberculosis Patients: Cross Sectional Study (Preprint)
Authors: Latif Aulia Insani , Sjattar Elly Lilianty , Erika Kadek Ayu
Published: October 2024

BACKGROUND

Background: Tuberculosis is the deadliest disease in the world caused by progressive transmission and the lack of knowledge of TB patients.

OBJECTIVE

Objective: This study aims to develop, evaluate and assess knowledge about prevention of transmission and medication adherence for tuberculosis patients based on AILs TB application.

METHODS

Method: This cross-sectional study consisted of three phases. The first phase is content development uses Delphi Study which was carried out in 3 rounds involving 13 experts to produce consensus on prevention of transmission and medication adherence. The second phase is the application development process carried out by IT experts assessed by involving 4 experts used content validity index. The third phase was carried out by a Pilot Study involving 15 TB patients in each intervention and control group determined based on inclusion and exclusion criteria to assess changes in knowledge about prevention of transmission and medication adherence

RESULTS

Results: Delphi study results produce 9 themes for consensus prevention of transmission and 12 themes for consensus on treatment adherence. Then the appraisal reached the agreement of the experts with the content validity index value >80%. Furthermore, the results of the Pilot Study showed an increase in knowledge in TB patients after being given education through AILs TB application with p value = 0.001.

CONCLUSIONS

Conclusions: The TB AILs application that has been developed based on consensus results is able to increase knowledge about prevention of transmission and treatment adherence of TB patients
Requirements and preferences for a digital health application for individuals living with rare conditions: A multi-methods study (Preprint)
Authors: Boyd Kyle , Bai Lu , Bond Raymond , Wallace Jonathan , Mulvenna Maurice , Leigh Simon , Stevens Sebastien , Toland Patrick
Published: October 2024

BACKGROUND

Individuals living with rare conditions often face unique challenges, including difficulties in access diagnosis, treatment, and support. Digital health applications present an opportunity to support self-management for these individuals. However, understanding the specific requirements and preferences for such an app is crucial to ensure its effectiveness.

OBJECTIVE

The primary objective of this study was to identify the needs, preferences, and concerns related to the use of digital health applications for the self-management of rare diseases. This was achieved by gathering insights from key stakeholders, including individuals with rare conditions, their informal carers, healthcare professionals, and other stakeholders.

METHODS

A multi-methods approach, including co-creation and co-production techniques, was employed. The study utilized an online survey and a workshop to collect data. A total of 28 participants were involved (19 survey completions and 9 workshop participants). The survey and workshop aimed to gather participant perceptions regarding personal health data collection, data sharing preferences, concerns, and potential features for a digital health app tailored to rare conditions. Ethical approval was obtained from the University Research Ethics Committee.

RESULTS

Key findings revealed a strong desire for app features such as comprehensive symptom tracking, educational resources, and a platform for community connectivity. Participants expressed a willingness to contribute their personal health data to advance research into rare diseases and improve care, but they also showed reservations about the potential misuse of their data, particularly when sharing with companies. Identified requirements included a glossary of terms for specific rare diseases, symptom logging, connectivity with others having similar conditions, mental health support, and secure data handling.

CONCLUSIONS

This study underscores the potential of digital health technology to significantly improve the management and understanding of rare conditions. Despite the small sample size, the study’s methodology and survey design offer valuable insights that can be applied in larger, more diverse populations. The research highlights the importance of incorporating user and stakeholder input in designing digital health solutions, ensuring these technologies are tailored to the unique needs of the rare disease community.
Impact of intra nasal administration of Ayurveda Medicine in apparently Healthy individuals on neuro-physiological variables and functional connectivity in Brain-Study protocol of an Exploratory Randomized Controlled Trial using f-MRI (Preprint)
Authors: NAIR DEVI , C J Sandya , Jameela Sophia , E Remya , Moorthy Srikanth , Parasuram Harilal , Khanduri Shruti , Rao Bhogavalli Chandrasekhar , Srikanth Narayanam , Acharya Rabinarayan
Published: October 2024

BACKGROUND

Nasya karma, Ayurveda nasal drug delivery system, is considered as one of the potent therapeutic modalities among Panchakarma. The uniqueness of the procedure lies in the fact that nasal drug delivery can bypass normal liver metabolism and BBB (Blood Brain Barrier), opening up a faster drug-delivery pathway. Available studies on ‘Nasya’ focus mainly on the efficacy of the same. This pioneering study aims to explore the mechanisms of nasya karma on brain function and neurophysiology, investigating its potential to modulate activity in specific brain regions and affect the functional connectivity between these regions using functional MRI.

OBJECTIVE

The study aims to map the neuro-physiological response of brain to Nasya using BOLD functional MRI in both rest and task phases and to assess its impact on quality of life, cognition, sleep, and psychological well-being in healthy volunteers.

METHODS

60 healthy volunteers, in the age group of 20-40 years fulfilling the selection criteria will be recruited for this RCT from National Ayurveda Institute of Panchakarma, Kerala, India and randomized in 1:1 ratio to either the intervention group, n=30 (Group I receiving Nasya with Anu Taila for a period of 14 days) or the Control Group, n=30 (Group II), not receiving any intervention. The participants will undergo task based and resting f-MRI on day 1(twice on day 1, before administration and 15 minutes after Nasya for participants in Group I) and day 14 to map the neuro-physiological response of Nasya on brain. A comprehensive neuroimaging protocol using structural and functional magnetic resonance imaging will be employed in the study.Effect of Nasyain sleep, psychological domain, cognitive function, quality of life domain will be assessed on 1st day and 30th day in both the groups.

RESULTS

This study will investigate the neurophysiological mechanisms of Nasya by examining clinical, neuropsychological, and neuroimaging variables to identify associated neural patterns to develop therapeutic protocols for manu diseases. The findings will also provide evidence for future research, supporting the use of Nasya as a practical and noninvasive therapeutic modality for treating cerebrovascular, behavioral, and neurological disorders, as indicated in Ayurveda.

CONCLUSIONS

The study will propel innovative research focusing on the neural mechanisms responsible for the delivery of central nervous system therapeutics to the brain and thereby bypassing BBB and generating favorable outcomes in CNS diseases

CLINICALTRIAL

Trial has been registered prospectively in Clinical Trial Registry of India with registration number CTRI/2023/06/054219 dated 20.06.2023
What about the use of Wearable Sensors to assess Fall Risk in Neurological Disorders? A Systematic Review. (Preprint)
Authors: Bonanno Mirjam , Ielo Augusto , De Pasquale Paolo , Celesti Antonio , De Nunzio Alessandro Marco , Quartarone Angelo , Calabrò Rocco Salvatore
Published: October 2024

BACKGROUND

The fall risk assessment, especially in neurological disorders, is essential to prevent hospitalization, hypomobility and reduced functional independence. Nowadays, the use of wearable sensors is catching on in the field of neurorehabilitation, as they allow an unsupervised fall risk assessment, providing continuous monitoring during daily functional tasks and thus reflecting subject’s real fall risk.

OBJECTIVE

We systematically reviewed literature on reliable biomechanical gait parameters detected with wearable devices to assess fall risk in neurological disorders, focusing on Parkinson's disease, multiple sclerosis, and post-stroke patients. Additionally, we examined the latest advancements in wearable sensor technology, including best practices for device positioning and data processing techniques.

METHODS

Our comprehensive systematic review search was conducted for all peer-reviewed articles published up to 31 December 2023, using the following databases: PubMed, Web of Science, Embase, and IEEE Xplore, which are the most used databases in the context of health and bioengineering field.

RESULTS

The 16 included studies involved 2.465 neurological patients, including 189 patients with MS (7 studies), 2.246 patients with PD (9 studies), and 30 patients with stroke (2 studies).

CONCLUSIONS

This review highlights the role of wearable technologies in assessing fall risk in neurological patients. While studies showed variation in methods and a focus on technology over clinical context, the lack of standardization reflects ongoing advancements, which may be seen as a strength.

CLINICALTRIAL

PROSPERO registration ID: CRD42023463944
Evaluating the Impact of Conversational and Animation Virtual Agent Features in a Mental Health App on Depressive Symptoms and User Experience in College Students: A Randomized Controlled Trial (Preprint)
Authors: Six Stephanie , Schlesener Elizabeth , Hill Victoria , Babu Sabarish , Byrne Kaileigh
Published: October 2024

BACKGROUND

Numerous mental health applications (MHealth apps) purport to alleviate depressive symptoms. Strong evidence suggests that brief cognitive behavioral therapy (bCBT)-based MHealth apps can decrease depressive symptoms, yet there is limited research elucidating the specific features that may augment its therapeutic benefits. One potential design feature that may influence effectiveness and user experience is the inclusion of virtual agents that can mimic realistic, human face-to-face interactions.

OBJECTIVE

The goal of the current experiment was to determine the effect of conversation and animation virtual agent features within a bCBT-based MHealth app on depressive symptoms and user experience in college students with and without depressive symptoms.

METHODS

College students (N=209) completed a two-week intervention in which they engaged with a bCBT-based MHealth app with a customizable therapeutic virtual agent that varied in conversational and animation features. A 2 (Time: Baseline vs. Two-Week Follow-Up) x 2 (Conversational vs. Non-Conversational Agent) x 2 (Animated vs. Non-Animated Agent) randomized controlled trial was utilized to assess mental health symptoms (PHQ-8, PSS-10, and RRS questionnaires) and user experience (MAUQ questionnaire) in college students with and without current depressive symptoms. MHealth app usability and qualitative questions regarding users’ perceptions of their therapeutic virtual agent interactions and customization process were assessed at follow-up.

RESULTS

Mixed ANOVA results demonstrated a significant decrease in symptoms of depression (P = .002; M = 5.50±4.86 at follow-up vs. M = 6.35±4.71 at baseline), stress (P = .005; M = 15.91±7.67 at follow-up vs. M = 17.02±6.81 at baseline), and rumination (P = .028; M = 40.42±12.96 at follow-up vs. M = 41.92±13.61 at baseline); however, no significant effect of conversation or animation was observed. Findings also indicate a significant increase in user experience in animated conditions. This significant increase in animated conditions is also reflected in the user’s ease of use and satisfaction (F(1, 201) = 102.60, P < .001), system information arrangement (F(1, 201) = 123.12, P < .001), and usefulness of the application (F(1, 201) = 3667.62, P < .001).

CONCLUSIONS

The current experiment provides support for bCBT-based MHealth apps featuring customizable, humanlike therapeutic virtual agents and their ability to significantly reduce negative symptomology over a brief timeframe. The app intervention reduced mental health symptoms, regardless of whether the agent included animation or conversational features, but animation features enhanced user experience. These effects were observed in both users with and without depressive symptoms.
Identification of prognostic biomarkers of chromatin remodeling in acute myeloid leukemia based on TCGA data analysis (Preprint)
Authors: LIU LANXIANG , ZHANG HONGBIN , WANG LI , LIU LIN , Yan Xinyu
Published: October 2024

BACKGROUND

Acute myeloid leukemia (AML) is a malignancy of the blood system. The commonly altered regions in the genome of AML encompass a multitude of gene modifications associated with epigenetic regulation. However, the prognostic significance of chromatin remodeling-related genes (CRRGs) as an overall indicator has yet to be assessed in AML. 

OBJECTIVE

The purpose of our analysis results was to establish a solid theoretical foundation for the clinical treatment of AML.

METHODS

Uunivariate Cox regression analysis was performed for CRRGs. The Differential expressed genes (DEGs) between chromatin remodeling related AML subtypes in TCGA-AML were measured. CIBERSORT and ssGSEA algorithms were employed to compare disparities in immune responses. GSVA analysis was performed and tumor mutation burden (TMB) analysis was conducted. Using TIDE to assess patients' differences in sensitivity to immunotherapy. The construction and verification of the nomogram were carried out. Expression of biomarkers in healthy and AML patients was analyzed by RT-qPCR.

RESULTS

In TCGA-AML, a total of 3995 differential genes were identified. There were differences between two AML clusters in T cells CD4 memory activated and Dendritic cells activated. A total of 6 prognostic biomarkers were identified, namely ARF6, ASF1B, CHD5, FLNA, KDM5B, and SPI1. The high-risk group exhibited higher TIDE scores. A total of 29 drugs had lower IC50 values in high-risk group. We found that risk score was an independent prognostic factor for AML.RT-qPCR results showed significant differences in expression of ARF6, KDM5B and CHD5 between healthy and AML patients.

CONCLUSIONS

We identified six biomarkers, namely ARF6, ASF1B, CHD5, FLNA, KDM5B, and SPI1, thereby establishing a theoretical foundation for clinical diagnosis of AML.
Design and Application of Exclusive Service App for Rural Elderly
Authors: Bai Xiaotong , Dong Jie , Yu Jingtao , Wu Yingying , Shao Yina , He Xuan , Han Lu
Published: October 2024

With the further advancement of rural development and the rapid development of mobile Internet, rural service apps have gradually become an important means of promoting rural economic development and improving farmers’ production and living standards. At present, a number of service-type apps with wide applications in the field of rural services have emerged, such as “Planting Master”, “Farming Network”, “Rural Taobao”, etc. However, these apps do not pay special attention to special groups, but only target the majority of young people and office workers. However, these apps do not pay special attention to special groups, but only target the majority of young people and office workers. In order to fill this gap, we have designed a software called Nong’e Tong, which is specially designed for the elderly and other special groups. The software has a simple and beautiful interface, and is easy to use. It not only provides a lot of special functions, but also can link the elderly’s cell phone with their children’s cell phones to check the health and safety of the elderly at any time. Compared to other software, the application has special features for seniors to ensure that they can use the application easily and quickly.
EL CONTEXTUALISMO COMO UNA ALTERNATIVA METODOLÓGICA PARA EL ANÁLISIS NORMATIVO
Authors: Hernández Garduño Salvador
Published: October 2024

"El contextualismo como una alternativa metodológica para el análisis normativo" de Salvador Hernández Garduño explora cómo el contextualismo, originalmente utilizado para el análisis de ideas políticas, puede ser aplicado a la práctica jurídica. Este enfoque metodológico propone superar las limitaciones del textualismo tradicional, que tiende a atribuir interpretaciones ideológicas a los textos sin considerar adecuadamente el contexto histórico. En el ámbito jurídico, el contextualismo permitiría una comprensión más profunda de las normas, superando el análisis limitado de los argumentos legislativos y de las normas en sí mismas. En lugar de ello, aboga por considerar el contexto histórico y social en el que las normas fueron creadas para abordar la creciente complejidad de los problemas legales. Esto implica reconocer que las normas jurídicas están vinculadas a otras normas sociales y morales, y que el derecho, por sí solo, no puede resolver todos los problemas sociales actuales.
The Effect of a 30-Day Outpatient Intensive Lifestyle Intervention on Cardiometabolic Health
Authors: Grega Keith , Liotta Mark , Wolferz Rich , Weiss Ron
Published: October 2024

Background: Lifestyle modifications are a first-line treatment to prevent and reverse chronic disease. Lifestyle interventions with a holistic approach can rapidly address multiple risk factors, although adherence can be challenging. This study examined a 30-day, outpatient, intensive lifestyle intervention and its impact on multiple cardiovascular and metabolic risk factors.
Methods: This retrospective, observational study included patients at a primary care practice who participated in an innovative, 30-day program consisting of a multifaceted approach to intense lifestyle intervention including a whole food, plant-based diet, daily aerobic exercise, sleep hygiene, and mindfulness-based stress reduction education with regular follow-up and guidance from both lifestyle coaches and physicians. Patients’ pre- and post-program vital signs and lab results were retrospectively reviewed and analyzed for individuals who completed the program from September 2015 to June 2022.
Results: Of the 112 participants who met the study criteria, there were a total of 42 males and 70 females with a mean age of 54.8 ± 11.9 years. Participants experienced an average decrease in systolic blood pressure of 11.6 ± 17.4 mmHg (p<0.0001), decrease in diastolic blood pressure of 3.4 ± 10.9 mmHg (p<0.01), and weight loss of 13.6 ± 8.0 lbs (p<0.0001). Lab values showed an average decrease in total cholesterol of 32.2 ± 33.2 mg/dL (p<0.0001), low-density lipoprotein of 19.5 ± 29.3 mg/dL (p<0.0001), A1c of 0.6 ± 0.8% (p<0.01), and high-sensitivity C-reactive protein of 0.9 ± 4.3 mg/L (p = 0.045). Medication deprescribing at onset of intervention occurred in 34 of 41 participants on anti-hypertensives, 14 of 16 participants on lipid-lowering medications, and 12 of 12 participants on anti-diabetic medications. In addition, some participants reported resolution of chronic symptoms including gastroesophageal reflux disease, fatigue, nocturia, and insomnia.
Conclusion: A 30-day, outpatient, intensive lifestyle intervention program for primary care patients was successful at improving numerous health vital signs and metabolic risk factors. The intervention allowed for medication deprescribing in most patients on anti-hypertensive, lipid-lowering, and anti-diabetic medications. Future directions should include longitudinal follow-up of sustained impact.
Learning Reflection Using Realistic Mathematics Education Assisted by GeoGebra Software
Authors: Hardiyanto Dwi , Asokawati Indhi , Majid Panji Maulana , Maesaroh Atika Tri , Nursyahidah Farida
Published: October 2024

Reflection material is very important for students to master when studying transformation material. However, reflection material is still difficult for students to understand. Therefore, this research aims to create a learning trajectory that can help students understand the concept of reflection using the context of the Tedhak Siten tradition with the help of GeoGebra software in grade 9th of SMP Negeri 6 Semarang. This research uses a design research method consisting of three stages: preliminary design, design experiment, and retrospective analysis. In this research, a series of learning activities were designed and developed based on the (Realistic Mathematics Education) RME approach. This research involved 6 grade 9th students. The result of this research is a learning trajectory that includes a series of learning processes in three activities, namely: 1) Observing the Tedhak Siten tradition video to find the definition and characteristics of reflection; 2) Finding formulas and reflection results; and 3) Resolving contextual problems related to reflection. The conducted activity can aid in improving students’ comprehension of reflection material. The research results showed that students could discover the characteristics and definitions of reflection, find formulas and reflection results, and solve contextual problems related to reflection.
Ethnomathematics: Exploration of Mathematical Concepts on the Process of Madurese Salt Production
Authors: Hanik Umi , Efendy Makhfud , Jannah Ana Naimatul , Fatmawati Ira
Published: October 2024

The exploration of mathematical concepts as a human activity triggers the need to research ethnomathematics. This research is the analysis of fundamental activities of mathematics on the process of Madurese Salt Production in Pamekasan. This qualitative study was conducted using ethnography, and the data were obtained from conducting in-depth interviews and observations with some salt farmers. The analysis findings of fundamental activities of mathematics on the process of Madurese Salt Production are: 1) locating: choosing pond location based on the soil, water, and weather; 2) designing: designing the layout of brine pond and considering the plots based on the functions; 3) measuring: measuring the seawater concentration, the level of the water as raw materials, the thickness of salt crystals, the plots, and; 4) counting: calculating workers' wage and profit and  loss; 5) playing, solving unpredictable weather to be able to be; and 6) explaining: the salt farmers shared hereditary knowledge about windmill. The results can be used as a source for the development of teaching materials in mathematics learning based on ethnomathematics on the process of Madurese salt production.