bluuebunny/crossref_metadata_2025 huggingface dataset:
SOLVING THE “PROBLEM” OF WILLS FORMALITIES IN THE MODERN POST-PANDEMIC SOCIETY: CAN THE ENDLESS DISCUSSION BE CONCLUDED?
Authors: Załucki Mariusz
Published: October 2021

The last will as an instrument of succession law is one of the means of disposing property upon death. Around the world particular legal regulations of American, Australian, European or other countries generally provide for different specific formal requirements for the valid preparation of will. The inappropriateness of this kind of solutions was shown, among others, during the COVID-19 pandemic, when the need for making last wills has increased significantly and has rarely been executed in a manner consistent with the formalities. Reflecting the intent of a testator, often expressed informally, seems to be a more important value of the law of succession than respecting the formalities. This has already been noticed in some countries, especially in common law jurisdictions in Australia and America, where solutions based on substantial compliance doctrine or its variations, contrary to the pan-European strict compliance standard, were adopted. These solutions, however, do not take into consideration plenty of circumstances that may occur in the testation practice and are indifferent to new possible ways of making wills. Meanwhile, the range of mechanisms and proposals for statutory changes in the area of wills formalities is constantly growing. However, there are no proposals to cover all possible legislations in this area, as regards Anglo-American, European or other countries. Yet such a solution seems possible and desirable in order to reconcile the doctrines of substantial compliance and strict compliance. This proposal is the subject of this study.
Social History of European Integration
Authors: Kaelble Hartmut
Published: October 2021

In theory, the social history of European integration could be written in three different ways.l The first method would be to adopt the perspective of political historians and political scientists, who would apply social history to learn about new, neglected, but powerful factors affecting European integration. They might, for instance, try to identify those social factors underlying the founding of the European coal and steel community in 1950 or discuss the social background behind the creation of the European Economic Community in 1957.
The Impact of Reciprocal Teaching on Pre-Service English-as-a-Foreign-Language Teachers’ Reading Comprehension Skills
Authors: KOŞAR Gülten , AKBANA Yunus Emre
Published: October 2021

This quasi-experimental study explored the impact of a seven-week intervention in reciprocal teaching (RT) on improving pre-service English-as-a-foreign-language (EFL) teachers’ (PSEFLTs) reading comprehension skills. The experimental group (N = 56) were subjected to an intervention designed to help them understand and apply the steps in RT while the control group (N = 53) attended to reading classes taught conventionally. Data was collected from a pre-reading test administered prior to the commencement and a post-reading test administered following the intervention, and a semi-structured interview. The findings revealed there was no statistically significant difference in experimental and control participants’ reading comprehension skills in the pre-reading test; nevertheless, the experimental group outperformed the control group in the post-reading test. Analysis of the qualitative data demonstrated the PSEFLTs viewed the RT intervention as effective in developing their reading comprehension skills and would implement it in their future teaching.
A MICROSCOPY AND MOLECULAR STUDIES OF NOSEMA CERANAE INFECTION IN MAZANDARAN PROVINCE OF IRAN
Authors: Shirzadi Ali , Razmi Gholamreza
Published: October 2021

Nosema ceranae as a fungal parasite has been reported from the Apis mellifera in all continents. It causes reduced longevity, depopulation, decreased production, and colony losses in honeybee colonies. This study aimed to determine the prevalence of N.ceranae in the apiaries of Mazandaran province. In this study, we randomly selected 320 hives from thirty-two apiaries and collected twenty old honeybees from the apiaries. The collected samples were examined by microscopy and molecular methods. The results of the microscopic examinations showed that 78.12% of apiaries were infected with Nosema spp. In addition, N. ceranae was identified 84.37% of apiaries by PCR, while no samples were infected by N. apis. Blast analysis of the sequenced samples confirmed the presence of N. ceranae infection in the apiaries. Based on the obtained results, a high frequency of N.ceranae was detected in apiaries in Mazandaran province.
Synthesis of Nb/MCM-48 material using rice husk ash as silica source with different SI/NB molar ratios
Authors: De Aguilar Pedott Victor , Bordin Iemedelais , Elisa Demaman Oro Carolina , Jorge Macieski Ricardo , Ivan Petkowicz Diego , Exenberger Finkler Diana , Marcos Dallago Rogério , Henrique Zimnoch dos Santos João , Mignoni Marcelo
Published: October 2021

The large amount of rice produced in Brazil generates a large volume of co-products, such as, Rice Husk (RH) and Rice Husk Ash (RHA). These co-products have amounts of silicon (Si) present in their structure, which can be used to synthesize silica-based materials as zeolites and MCM-type structures. The synthesis of MCM-48 material was carried out at room temperature, using the ionic liquid [C16MI·Cl] as structure-directing agent, depositing the niobium in situ during the synthesis with different molar ratios of Si/Nb (5, 20, 50 and 80). The material obtained was subjected to characterization by X-Ray Diffraction (XRD), Nitrogen Adsorption/Desorption isotherms and Scanning Electron Microscopy (SEM). The results confirm the formation of Nb/MCM-48 materials, in which their properties are consistent with those described in the literature. The deposition of Nb on MCM-48 did not change its structural properties, such as specific surface area and pore distribution for Si/Nb higher than 5. The results obtained demonstrate the success in the synthesis of mesoporous materials Nb/MCM-48 using industrial residues of rice as an alternative source of silicon, and in situ deposition of the niobium metal on the structure.
Avaliação dos índices zootécnicos de poedeiras em sistema de produção Cage-Free
Authors: Cechin Daniela , Patricia Freitas Carla , Ruschel dos Santos Luciana , Do Amaral Antônio Sergio , Dos Santos de Oliveira Daniela , Teixeira Amito José
Published: October 2021

A mudança no padrão alimentar dos consumidores por produtos mais saudáveis e a preocupação com o bem-estar dos animais, levou o setor avícola a buscar alternativas para produção de ovos sem a utilização de gaiolas, como o sistema de produção cage-free. No entanto, poucos estudos investigaram a influência desse sistema nos índices zootécnicos da produção de ovos, o que levou ao desenvolvimento desse estudo de caso. No estudo foram utilizados 400 aves poedeiras da linhagem Isa Brown, com idade inicial de 12 semanas e os dados coletados na 17ª semana de idade até 62ª semana de idade. As variáveis analisadas foram o início da postura, pico de produção, produção de ovos, consumo de ração e a mortalidade das aves. Os resultados mostraram que as aves iniciaram a postura precocemente (17ª semana de idade) com pico de produção na 24ª semana de idade e produtividade de 390 ovos/dia. O consumo de ração foi de 1,661kg para a produção de uma dúzia de ovos e mortalidade de 3% do lote. Com isso, demonstra que o sistema cage-free, em estudo, foi viável nos resultados dos índices zootécnicos, podendo, também, ser promissor quanto à nova exigência do mercado consumidor em relação ao bem-estar animal.
Carcinoma indiferenciado metastático em bovino leiteiro: relato de caso
Authors: Dariva Fernada , Valduga Paola Carla , Lira Ana Luiza , Colet Rosicler , Ruzycki Juliana Franciele , Setim Diorges Henrique , De Almeida Mauro Antônio , Toniazzo Backes Geciane , Oliveira Daniela dos Santos de
Published: October 2021

O carcinoma, tumor maligno, pode conter arranjos celulares em ninhos, cordões e/ou ilhas de células epiteliais, sendo invasivo, com elevado potencial metastático. As neoplasias podem ser oriundas de alterações genéticas hereditárias ou até mesmo de causas químicas, físicas (radiação) ou infecciosas, e se farão presentes em todas as células do organismo. Sendo geralmente diagnosticadas no post mortem, o aparecimento de tumores em bovinos não é considerado um achado corriqueiro, pois acredita-se que a maioria deles não atinge uma idade suficiente para predispor ao desenvolvimento de neoplasias. O objetivo do trabalho foi relatar um achado de necropsia em uma vaca da raça Holandesa preta e branca, com 7 anos de idade e 200 dias de lactação. Foi realizada a anamnese do animal na propriedade rural e após relatos do produtor procedeu-se avaliação clínica, realizando-se a palpação retal, que com prognóstico desfavorável, definiu-se a eutanásia do animal. Foi realizada necropsia e foram coletados fragmentos da glândula mamária, linfonodos mesentéricos, ilíacos e dos rins. O diagnóstico de carcinoma indiferenciado metastático foi confirmado através de exame macroscópico e microscópico. Estas neoplasias são uma das principais causas de descarte precoce de bovinos.
ON PITIRIM SOROKIN, CIVILIZATIONAL THEORY, AND CREATIVE ALTRUISM
Authors:   National University of Life and Environmental Scienсes of Ukraine, Kychkyruk T. , Salata H. ,   Kyiv National University of Culture and Arts
Published: October 2021

Among a wide variety of approaches to civilizational interactions, a special place belongs to the legacy of Pitirim Sorokin – the renowned Harvard sociologist who contributed greatly to macrosociology, philosophy of history, theory and history of civilizations. A deep study of the legacy of the great sociologist and humanist Pitirim Sorokin can provide us with intellectual resources and brilliant insights we need to outline new ways for human development. The paper aims to explore the civilizational theory of Pitirim Sorokin. The authors used cultural-historical and integrative approaches.
The Road Not Taken
Authors: Mark Maya
Published: October 2021

This article explores the position taken by the Herut party and its leader, Menachem Begin, on fundamental issues of democracy and regime type. It analyzes the democratic model that Begin and Herut sought to promote during Israel’s formative years: a presidential democracy with a clearly defined separation of powers preserved in a rigorous formal constitution that includes both judicial supremacy and a mechanism for judicial review. The article illuminates an important and unexplored chapter in Israeli historiography—the right wing’s position on the formation of Israel’s democratic regime—and addresses the ideological roots and foundations of the Likud movement in the spheres of government and law.
Book Reviews
Authors: Reiter Yitzhak , Lazarus Ned , Ben-Eliezer Uri , Mahalel Adi , Sasson-Levy Orna , Rosenberg Shalom
Published: October 2021

Moshe Ma’oz, Jews, Muslims and Jerusalem: Disputes and Dialogues (Eastbourne: Sussex Academic Press, 2021), 288 pp. Paperback, $39.95. Kindle, $37.95.

Yael Warshel, Experiencing the Israeli-Palestinian Conflict: Children, Peace Communication and Socialization (Cambridge: Cambridge University Press, 2021), 336 pp. Hardback, $99.99. Kindle, $80.00.

Shay Hazkani, Dear Palestine: A Social History of the 1948 War (Stanford, CA: Stanford University Press, 2021), 348 pp. Hardback, $90.00. Kindle, $21.49.

Nitzan Lebovic, Zionism and Melancholy: The Short Life of Israel Zarchi (Bloomington: Indiana University Press, 2019), 186 pp. Hardback, $80.00.

Ayelet Harel-Shalev and Shir Daphna-Tekoah, Breaking the Binaries in Security Studies: A Gendered Perspective of Women in Combat (Oxford: Oxford University Press, 2020), 168 pp. Hardback, $74.00.

Anat Y. Zanger, Jerusalem in Israeli Cinema: Wanderers, Nomads, and the Walking Dead (London: Vallentine Mitchell, 2020), 166 pp. Hardback, $89.95.
Corpus Callosum Atrophy in Detection of Mild and Moderate Alzheimer’s Disease Using Brain Magnetic Resonance Image Processing and Machine Learning Techniques
Authors: Das Subhrangshu , Panigrahi Priyanka , Chakrabarti Saikat
Published: October 2021

Background:

The total number of people with dementia is projected to reach 82 million in 2030 and 152 in 2050. Early and accurate identification of the underlying causes of dementia, such as Alzheimer’s disease (AD) is of utmost importance. A large body of research has shown that imaging techniques are most promising technologies to improve subclinical and early diagnosis of dementia. Morphological changes, especially atrophy in various structures like cingulate gyri, caudate nucleus, hippocampus, frontotemporal lobe, etc., have been established as markers for AD. Being the largest white matter structure with a high demand of blood supply from several main arterial systems, anatomical alterations of the corpus callosum (CC) may serve as potential indication neurodegenerative disease.

Objective:

To detect mild and moderate AD using brain magnetic resonance image (MRI) processing and machine learning techniques.

Methods:

We have performed automatic detection and segmentation of the CC and calculated its morphological features to feed into a multivariate pattern analysis using support vector machine (SVM) learning techniques.

Results:

Our results using large patients’ cohort show CC atrophy-based features are capable of distinguishing healthy and mild/moderate AD patients. Our classifiers obtain more than 90%sensitivity and specificity in differentiating demented patients from healthy cohorts and importantly, achieved more than 90%sensitivity and > 80%specificity in detecting mild AD patients.

Conclusion:

Results from this analysis are encouraging and advocate development of an image analysis software package to detect dementia from brain MRI using morphological alterations of the CC.
Cost of Care in Open Cystectomy Patients Across Time and Space: Does it matter?
Authors: Sun Helen H. , Prunty Megan , Isali Ilaha , Mahran Amr , Ginsburg Kevin , Markt Sarah , Ponsky Lee , Calaway Adam , Bukavina Laura
Published: October 2021

BACKGROUND:

Many variables may affect the cost of open radical cystectomy (RC) care, including surgical approach, diversion type, patient comorbidities, and postoperative complications.

OBJECTIVE:

To determine factors associated with changes in cost of care following open radical cystectomy (ORC) for bladder cancer using the National Inpatient Sample (NIS).

METHODS:

Patients in the NIS with a diagnosis of bladder cancer who underwent ORC with ileal conduit from 2012–2017 using ICD-9-CM and ICD-10-CM codes were identified. Baseline demographics including age, race, region, postoperative complications, and length of stay were obtained. Univariable and multivariable logistic regression were used to identify factors associated with cost variation including demographics, clinical characteristics, surgical factors, and discharge quarter (Q1-Q4).

RESULTS:

5,189 patients were included in the analysis, with 4,379 at urban teaching hospitals. On multivariable regression analysis, female sex [$1,734 ($1,024–2,444) p < 0.001)], a greater Elixhauser comorbidity score [$93 ($62–124), p < 0.001], presence of any inpatient complication [$1,531 ($894–2,168), p < 0.001], and greater length of stay [$1,665 ($1,536–1,793), p < 0.001] were associated with a greater cost of hospitalization. Discharge in Q3 (July to September) relative to Q2 (April to June) was associated with a higher cost [$1,113 ($292–1,933), p = 0.008. Trends were similar at urban non-teaching and rural hospitals, except discharge quarter was not associated with a significant change in cost.

CONCLUSIONS:

Significant differences in cost of ORC with ileal conduit exist with respect to patient sex, medical comorbidities, and discharge timing. These differences may relate to greater disease burden in female patients, patient complexity, and variation in postoperative care in academic programs.
General models for topology layout of oil and gas star-tree pipeline network
Authors: Zhou Jun , Zhang Daixin , Zhou Liuling , Liang Guangchuan , Zhou Xuan , Li Zelong
Published: October 2021

Oil&gas gathering pipeline network structure is a significant part of oil&gas field construction, and the rational construction of pipeline network is directly related to the efficiency and benefits of oil&gas field production. Therefore, optimizing the gathering and transportation system of oil and gas fields is the key to reducing development costs. The star-tree type pipe network is widely used in the gathering and transportation system. In order to optimize the star-tree pipe networks (STPNs) that has restrictions on the processing capacity and gathering radius of the station as a whole, this paper establishes four models of pipe network layout with specific constraints. They are Mixed-Integer Linear Programming Models with a large number of discrete variables. We take two virtual fields as examples, use CPLEX solver to solve the above four models as a whole, to obtain the optimal scheme, and also figure out the investment of the pipeline network. We further optimize the hierarchical optimization of the pipeline network with special constraints, then compare and analyze results obtained by the overall optimization. Finally, models are applied to an actual oil field and an actual gas field as examples to optimize the layout, which verifies the validity and feasibility of the models.
Wireless monitoring algorithm of intelligent greenhouse based on fuzzy control
Authors: Wang Xiangling
Published: October 2021

The existing greenhouse monitoring algorithm has a long delay time, so it is unable to carry out effective remote greenhouse monitoring, therefore, a new wireless monitoring algorithm based on the fuzzy control technolog was put forward, which was able to remotely monitor the greenhouse temperature, humidity and illumination data in real time. Firstly, the overall framework of greenhouse monitoring algorithm was built, including fuzzy clustering algorithm and sensing layer devices. Secondly, the temperature-humidity sensors and light sensitivity sensors in the sensing layer devices were used to deeply mine and optimize the parameters of temperature, humidity and light intensity in current greenhouse, so as to ensure the stability of subsequent transmission. Meanwhile, the corresponding perceptual recognition layer and broadband access method were designed, and GPRS technology was used to feed back the data information to the monitoring data layer through temperature-humidity sensors and light sensitivity sensors. Moreover, UDP protocol was taken as the data core transmission protocol, and the adaptive protection design algorithm was proposed to ensure the most reasonable transmission of monitoring data, get the current monitoring data of temperature, humidity and illuminance. The experimental results show that the maximum delay time of the algorithm is 46 s, which is far lower than the traditional algorithm, and the delay time of temperature monitoring is also lower than the traditional algorithm. It is results show that the response delay of remote intelligent greenhouse monitoring algorithm is low and the overall monitoring effect is ideal. The purpose of monitoring temperature, humidity and illumination can be achieved.
Neural networks for long-term earthquake prediction using modified meta-learning
Authors: Maya Mario , Yu Wen , Telesca Luciano
Published: October 2021

Neural networks have been successfully applied for modeling time series. However, the results of long-term prediction are not satisfied. In this paper, the modified Meta-Learning is applied to the neural model. The normal Meta-Learning is modified by time-varying learning rates and adding a momentum term to improve convergence speed and robustness property. The stability of the learning process is proven. Finally, two experiments are presented to evaluate the proposed method. The first one shows an improvement in earthquakes prediction in the long-term, and the second one is a classical Benchmark problem. In both experiments, the modified Meta-Learning technique minimizes remarkably the mean square error index.
Lexical attention and aspect-oriented graph convolutional networks for aspect-based sentiment analysis
Authors: Li Wenwen , Yin Shiqun , Pu Ting
Published: October 2021

The purpose of aspect-based sentiment analysis is to predict the sentiment polarity of different aspects in a text. In previous work, while attention has been paid to the use of Graph Convolutional Networks (GCN) to encode syntactic dependencies in order to exploit syntactic information, previous models have tended to confuse opinion words from different aspects due to the complexity of language and the diversity of aspects. On the other hand, the effect of word lexicality on aspects’ sentiment polarity judgments has not been considered in previous studies. In this paper, we propose lexical attention and aspect-oriented GCN to solve the above problems. First, we construct an aspect-oriented dependency-parsed tree by analyzing and pruning the dependency-parsed tree of the sentence, then use the lexical attention mechanism to focus on the features of the lexical properties that play a key role in determining the sentiment polarity, and finally extract the aspect-oriented lexical weighted features by a GCN.Extensive experimental results on three benchmark datasets demonstrate the effectiveness of our approach.
Keyword coupling query of spatiotemporal data based on XML
Authors: Bai Luyi , Cui Zengmei , Duan Xinyi , Fu Hao
Published: October 2021

With the increasing popularity of XML for data representations, there is a lot of interest in keyword query on XML. Many algorithms have been proposed for XML keyword queries. But the existing approaches fall short in their abilities to analyze the logical relationship between keywords of spatiotemporal data. To overcome this limitation, in this paper, we firstly propose the concept of query time series (QTS) according to the data revision degree. For the logical relationship of keywords in QTS, we study the intra-coupling logic relationship and the inter-coupling logic relationship separately. Then a calculation method of keyword similarity is proposed and the best parameter in the method is found through experiment. Finally, we compare this method with others. Experimental results show that our method is superior to previous approaches.
PhraseAttn: Dynamic Slot Capsule Networks for phrase representation in Neural Machine Translation
Authors: Nguyen Binh , Le Binh , Nguyen Long H.B. , Dinh Dien
Published: October 2021

Word representation plays a vital role in most Natural Language Processing systems, especially for Neural Machine Translation. It tends to capture semantic and similarity between individual words well, but struggle to represent the meaning of phrases or multi-word expressions. In this paper, we investigate a method to generate and use phrase information in a translation model. To generate phrase representations, a Primary Phrase Capsule network is first employed, then iteratively enhancing with a Slot Attention mechanism. Experiments on the IWSLT English to Vietnamese, French, and German datasets show that our proposed method consistently outperforms the baseline Transformer, and attains competitive results over the scaled Transformer with two times lower parameters.
Achromobacter xylosoxidans infection and resistance monitoring in adult cystic fibrosis patients
Authors:   Multidisciplinary Сity Hospital No. 2, St. Petersburg, Russian Federation, Makhmutova V.R. , Gembitskaya T.E. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Chermensky A.G. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Titova O.N. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Kuzubova N.A. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
Published: October 2021

Aim: to evaluate the infection rate and resistance of isolated Achromobacter xylosoxidans to carbapenems in adult cystic fibrosis patients (CF). Patients and Methods: a retrospective analysis of the results of culture test and time-of-flight mass spectrometry MALDI-TOF was conducted: 685 sputum samples of 58 adult CF patients for a period of 5 years (2016–2020). To assess the sensitivity to imipenem and meropenem, the agar gradient diffusion and disk diffusion method were used. Results: the incidence of infection with A. xylosoxidans in adult CF patients for the period from 2016 to 2020 when monitoring a single sample of patients (n=24) to evaluate the occurrence of this pathogen with increasing age ranged from 16.6% in 2016–2017, increasing to 37.5% in 2018–2019, and with a further reduction to 20.8% (associated with disease fatal outcome in 3 of the 9 infected patients). There was no statistically significant dependence of the fatal outcome on infection with A. xylosoxidans. When analyzing the entire pool of patients (n=58) from 2016 to 2020, the release frequency of Pseudomonas aeruginosa remains approximately the same, varying from 63.3% to 46.5% and maintaining a numerical advantage in all follow-up periods, while the A. xylosoxidans infection ranges from 13.7% to 39.3%. In 2016–2018, 50% of isolates were sensitive to carbapenems, in 2018 — 53.8% of isolates, in 2019–2020 — the activity of obtained isolates decreased to 37.5% and 30.7%, respectively. Conclusion: despite the dynamics of indicators and the sample size, the dynamics over 5 years maintained a group-wide proportion of microbiome species dominated primarily by Pseudomonas infection and A. xylosoxidans. In our follow-up, the activity of carbapenems in relation to A. xylosoxidans has almost halved. KEYWORDS: cystic fibrosis, Burkholderia cepacia complex, Achromobacter xylosoxidans, Pseudomonas aeruginosa, lethality, antibiotic resistance, carbapenems. FOR CITATION: Makhmutova V.R., Gembitskaya T.E., Chermensky A.G. et al. Achromobacter xylosoxidans infection and resistance monitoring in adult cystic fibrosis patients. Russian Medical Inquiry. 2021;5(7):462–467 (in Russ.). DOI: 10.32364/2587-6821-2021-5-7-462-467.
Possibilities of immunocorrection in COVID-19 therapy of patients on an outpatient basis
Authors:   Megi Clinic, Ufa, Russian Federation, Mukhamadieva L.R. , Mavzyutova G.A. ,   Bashkir State Medical University, Ufa, Russian Federation, Mirsayeva G.Kh. ,   Bashkir State Medical University, Ufa, Russian Federation, Khasanova G.M. ,   Bashkir State Medical University, Ufa, Russian Federation, Galieva G.A. ,   Bashkir State Medical University, Ufa, Russian Federation, Abdrakhmanova G.M. ,   Bashkir State Medical University, Ufa, Russian Federation, Safina A.A. ,   City Clinical Hospital of the Demsky District, Ufa, Russian Federation
Published: October 2021

Aim: to evaluate the clinical efficacy of azoximer bromide inclusion in the complex therapy of patients with a confirmed diagnosis of COVID-19 (moderate degree) who were receiving treatment on an outpatient basis. Patients and Methods: data from medical records of 100 patients who were treated in outpatient clinics for COVID-19 in Ufa (June–November 2020) were retrospectively evaluated. There were 2 groups of 50 patients: the main group receiving azoximer bromide and the comparison group receiving only standard therapy. The criteria for evaluating the therapy efficacy were the dynamics of the disease clinical picture, laboratory parameters characterizing inflammation. Results: in the main group, the relief of complaints and a significant condition improvement according to physical examination were recorded significantly earlier — after 9.68±5.23 days versus 13.00±4.95 days in the comparison group (p=0.0012). The period of body temperature normalization in patients receiving immunomodulatory therapy was 7.20±1.41 days, which is significantly less than in patients receiving standard therapy — 16.20±2.74 days (p=0.0001). When contacting the outpatient clinic, all patients had an increase in the level of C-reactive protein: in the main group — up to 13.91±17.28 mg/L, in the comparison group — up to 12.22±8.32 mg/L (p=0.71). The result of therapy was a decrease in this indicator to 6.28±5.06 mg/L and 4.44±3.73 mg/L, respectively (p=0.0314). On the 17th day after the treatment initiation, all patients had antibodies (IgM and IgG) to SARS-CoV-2. Conclusions: azoximer bromide inclusion in the complex therapy of patients with COVID-19 allows for faster normalization of the patients’ condition, is not accompanied by adverse events and can be considered as a pathogenetic therapy variant of patients with COVID-19 with a predominantly severe course in the setting of concomitant diseases. KEYWORDS: coronavirus infection, SARS-CoV-2, COVID-19, pneumonia, immunocorrection, pathogenetic therapy, azoximer bromide. FOR CITATION: Mukhamadieva L.R., Mavzyutova G.A., Mirsayeva G.Kh. et al. Possibilities of immunocorrection in COVID-19 therapy of patients on an outpatient basis. Russian Medical Inquiry. 2021;5(7):468–472 (in Russ.). DOI: 10.32364/2587-6821-2021-5-7-468-472.
Therapeutic possibilities of using an expectorant mucolytic agent with antioxidant properties in COVID-19 infection
Authors:   South Ural State Medical University, Chelyabinsk, Russian Federation, Ignatova G.L. , Antonov V.N. ,   South Ural State Medical University, Chelyabinsk, Russian Federation, Sheklanova E.V. ,   Regional Clinical Hospital No. 3, Chelyabinsk, Russian Federation, Korotkaya M.A. ,   Regional Clinical Hospital No. 3, Chelyabinsk, Russian Federation, Domracheva M.V. ,   Regional Clinical Hospital No. 3, Chelyabinsk, Russian Federation, Zotov S.O. ,   Regional Clinical Hospital No. 3, Chelyabinsk, Russian Federation
Published: October 2021

Aim: to study the effect of N-acetylcysteine (NAC) on the dynamics of clinical and radiological changes in patients with COVID-19. Patients and Methods: the study included 111 patients with moderate and severe forms of COVID-19 pneumonia of the 2nd and 3rd stage according to computed tomography (CT). The median age was 49,25 years. Group 1 (n=55) received standard therapy: favipiravir, enoxaparin sodium according to the regimen, dexamethasone. Antibacterial therapy was conducted according to the indications. In addition to standard therapy, group 2 (n=56) was prescribed with NAC at a daily dose of 1200 mg, intravenously, divided into two doses. All patients underwent a comprehensive examination: WBC count, C-reactive protein (CRP), ferritin, fibrinogen, multispiral computed tomography and ultrasound of the chest organs were determined at admission, on the 7th-10th day of hospitalization, at discharge and 8 weeks after discharge. Results: initially, patients from both groups were comparable in terms of demographic indicators and condition severity. NAC prescription to the standard therapy showed a more positive trend both in terms of clinical symptoms and laboratory indicators. Respiratory rate, heart rate, and body temperature were statistically significantly lower in group 2 already on the 7th-10th day of follow-up. The levels of CRP, ferritin and fibrinogen also normalized faster in group 2. The periods of stay in the hospital were 15.3 days and 12.2 days, respectively, in patients from groups 1 and 2 (p<0,05). Conclusions: early prescription with N-acetylcysteine to patients with a moderate course of COVID-19 allowed statistically significantly reducing the volume of lung tissue damage, reducing the level of inflammatory markers (CRP, ferritin, fibrinogen) and contributed to an earlier discharge of the patient. KEYWORDS: COVID-19, N-acetylcysteine, pneumonia, acute respiratory distress syndrome, cytokine storm. FOR CITATION: Ignatova G.L., Antonov V.N., Sheklanova E.V. et al. Therapeutic possibilities of using an expectorant mucolytic agent with antioxidant properties in COVID-19 infection. Russian Medical Inquiry. 2021;5(7):473–478 (in Russ.). DOI: 10.32364/2587-6821-2021- 5-7-473-478.
Infracochlear access to the petrous apex (morphometrics)
Authors:   Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech, St. Petersburg, Russian Federation, Anikin I.A. , Khamgushkeeva N.N. ,   Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech, St. Petersburg, Russian Federation
Published: October 2021

Aim: to study morphometrics data of the infracochlear tunnel on the cadaveric temporal bones, sufficient for its rehabilitation. Patients and Methods: the study was performed on 30 cadaveric temporal bones. The measurement was made using a measurement probe, a micrometer ruler, and a digital caliper. The following parameters were studied: the distances concerning the location of the facial nerve in relation to the infracochlear tunnel; the distances between the anatomical structures of the infracochlear tunnel in its various sections (from the internal carotid artery to the jugular vein); the length of the infracochlear tunnel (bisector drawn between the internal carotid artery and the jugular bulb to the basal whorl of the cochlea); the depth of the infracochlear tunnel (distance to the petrous apex from the basal whorl of the cochlea). A comparative analysis of the results obtained with the data of other scientific studies was conducted. Results: infracochlear access on the cadaveric temporal bones was performed in our study only on 18 cadaveric temporal bones (60% of cases). During surgical access to the petrous apex, a 2 mm cutter was used to avoid injury to adjacent vessels. Based on the obtained data, differences in the structure of the infracochlear tunnel were noted depending on the pneumatization of the petrous apex. The main parameters of the infracochlear tunnel have been determined, which can be applied in the choice of surgical tactics for the removal of pathological formation from the petrous apex. Conclusions: there are the following anatomical prerequisites for conducting infracochlear access to the petrous apex for its lavage: infracochlear tunnel width from 5 mm, infracochlear tunnel length from 5.5 mm, the distance between the mastoid part of the facial nerve to the anterior margin of the cochlea window from 4.8 mm. These parameters can be applied in the assessment of patients’ CT scans to determine the indications for infracochlear access to the petrous apex. KEYWORDS: petrous pyramid, petrous apex, infracochlear tunnel, infracochlear access, cadaveric temporal bones, morphometrics. FOR CITATION: Anikin I.A., Khamgushkeeva N.N. Infracochlear access to the petrous apex (morphometrics). Russian Medical Inquiry. 2021;5(7):486–491 (in Russ.). DOI: 10.32364/2587-6821-2021-5-7-486-491.
Obtaining seeds of meadow clover in the Lower Volga region under irrigation
Authors: Burceva Natal'ya , Molokanceva Natal'ya
Published: October 2021

Abstract. The purpose of the experiment was to develop a technology for cultivating meadow clover under irrigation to obtain the planned seed yields in the conditions of the Lower Volga region. Research methods. Field experiments, records and observations were carried out in accordance with the generally accepted methods of experimental work. As a result of the research, it was found that the total water consumption of clover crops varied over the years of the herbage life and depended on the given pre-irrigation threshold of soil moisture. It was highest in the variants with the maintenance of the 70 % pre-flood threshold: 3.6–3.9, the lowest 2.7–3.1 thousand m3/ha in the variants with the 60 % humidity threshold. With the differentiation of humidity by the development phases, the total water consumption varied from 3.1 to 3.5 thousand m3/ha. The share of irrigation water in the structure of total water consumption was 60.6–72.7 % according to the experimental variants. The leaf area depended on the water and nutrient regimes of the soil: it reached the maximum values in the variants with a 70 % pre-irrigation threshold of humidity and fertilization. In comparison with the increase in biomass, the seed productivity of clover was less dependent on the photosynthetic potential and assimilation surface. The highest seed yields were formed in the variants with improved nutrition background and maintenance of a differentiated irrigation regime – 280–730 kg / ha. The accumulation of a significant amount of root mass by clover had a positive effect on improving the ecological state of the irrigated area: the water-physical properties of the soil improved, and nutrients accumulated in it. Scientific novelty. In the conditions of the Lower Volga region, the dependence of the seed productivity of clover on the availability of water and nutrients, on the age of the herbage, was revealed. Their optimal combination is determined for the production of seed yields at the level of 400–700 kg/ha.
Biological features of Allium nutans L. samples in the Bashkir Cis-Urals in the introduction
Authors: Tuhvatullina Lenvera , Zhigunov Oleg
Published: October 2021

Abstract. The purpose – to study under cultural conditions in the Bashkir Cis-Urals three samples of Allium nutans L.: Bashkir, Novosibirsk (broadleaf and narrow-leaved form). Studied: phenology, biomorphology, reproduction, agricultural technology and biochemical composition. Methods. The study was conducted in 2017–2020 at the collection site of onions in the South Ural Botanical Garden-Institute of the UFRC RAS. Analysis of the seasonal rhythm of growth and development, winter resistance, resistance to adverse weather conditions, pests and diseases, reproduction rate and seed productivity was carried out according to generally accepted recommendations. Results. Drooping onion is a long-lasting medium-late-flowering plant. Spring growth of A. nutans samples occurs in the 2nd–3rd decade of April, leaf growth in the spring is initially expressed in accelerating the growth processes of last year's etiolated leaves, and only then new young leaves come to the soil surface. The appearance of the flower arrow occurs in mid-June, the beginning of budding falls on the 2nd–3rd decades of June and lasts 30–35 days. Novosibirsk samples bloom in mid-July, the Bashkir sample – a week later. The flowering phase lasts an average of 35–41 days. Seeds ripen in August-September. In Novosibirsk samples, seeds mature in 16–19 days, in the Bashkir sample – in 25 days. The maximum number of seeds forms the Bashkir sample 647–1031 pcs. (average 835.0 ± 53.5). Scientific novelty. For the first time, the biochemical composition of samples of this onion was made and analyzed. According to the maximum accumulation of vitamin C and carotene, the Bashkir sample differs (104.92 mg% and 166.4 mg/kg, respectively). In the Novosibirsk sample (narrow-leaved form), the maximum amount of sugar and starch (8.8 and 6.12%, respectively) and the minimum amount of vitamin C (41.53 mg%) were found. The Novosibirsk sample (broadleaf form) contains more protein (17.06%) and a minimum amount of carotene (83.2 mg/kg). According to other indicators (solid, nitrogen, raw fat), the studied samples differ little from each other.
Investigate of the potential for diversification of the socio-economic ecosystem of the territory (on the example of the Kondinskiy Area of the Khanty-Mansiysk Autonomous Okrug – Ugra)
Authors: Starikov Evgeny
Published: October 2021

Abstract. The federal and administrative-territorial structure that has developed in Russia, institutional relations, as well as the methodology and instruments of strategic planning predetermine the significant role of municipalities in the preparation and implementation of strategies for socio-economic development. In this regard, the most important place in economic research is occupied by the problems associated with the development of mechanisms for the growth of the local economy and the formation of new effective models of territorial development. At the same time, taking into account the historical trend of monospecialization of the country's municipalities, the issues of investigating the potential for diversification of the markets of socio-economic ecosystems at the municipal level are of particular importance. The purpose of the work is to investigate and assess the development potential of markets for diversification of the territorial ecosystem of the municipal level. The object of the research is the territorial, socio-economic ecosystem of the Kondinsky Area of the Khanty-Mansiysk Autonomous Okrug-Yugra. Methodology and methods. The work used a set of scientific methods, the main of which is the method of expert assessment. In addition, the methodological toolkit of SWOT-analysis and forecasting was applied. Results. Taking into account the typicality of the chosen object of research, a significant result of the work is the approbation of the author's methodology, which can be used in the future to investigate the potential for diversification of the markets of municipal ecosystems in almost all regions of Russia. Also it was established that the main markets for diversification of the territorial ecosystem of the Kondinsky Area are new markets for the forestry business, formed on the basis of the development of small and medium-sized forms of management, the development of oil and gas fields with hard-to-recover reserves of raw materials based on the introduction of new technologies for oil and gas processing and petrochemical chemistry, as well as new agro-industrial markets, including animal husbandry, fish processing, collection and processing of wild plants. Scientific novelty. The analysis of approaches to the study of the concept of «ecosystem» is carried out. The markets for diversification of the socio-economic ecosystem of the Kondinsky Area were identified and the forecast of key indicators of the development of industrial markets for the period up to 2030 was carried out. Recommendations for local governments to improve the efficiency of realizing the potential of diversification markets are proposed.
Traspaso de la tasa de cambio a la inflación básica en Colombia: un análisis de parámetros cambiantes en el tiempo
Authors: Rincón-Castro Hernán , Rubiano-López Pedro , Yaya-Garzón Lisseth , Zárate-Solano Héctor M.
Published: October 2021

Cuánto de las variaciones de la tasa de cambio se traspasa a la inflación es una pregunta de principal interés para la autoridad monetaria, los inversionistas, el sector real y el mismo gobierno. Este documento estima el grado de traspaso de choques de la tasa de cambio del peso sobre la inflación básica en Colombia para cuatro momentos cambiarios críticos que enfrentó la economía: crisis internacional de las dot.com (2002), profundización de la crisis financiera internacional ante la quiebra de Lehman-Brothers (2008), colapso del precio internacional del petróleo (2014) y explosión mundial de la pandemia de la Covid-19 (2020). Para lograr el objetivo se utiliza información trimestral del período 2000 a 2020 y un modelo de vectores autorregresivos con parámetros cambiantes estimado por métodos Bayesianos. Los resultados indican que, primero, el grado de traspaso del choque cambiario a la inflación depende del choque y del tiempo. Segundo, un choque de 1% de la tasa de cambio del peso tuvo un traspaso máximo de 0,05% a la inflación básica en la destorcida del precio internacional del petróleo de 2014, de 0,03% en la crisis de las dot.com, de 0,02% en la quiebra de Lehman-Brothers y de 0,01% en el estallido de la pandemia del COVID-19.
Procedure for Handling 4-H Accounts: Guidelines for Creating Accounts
Authors: Norman Marilyn N. , Jordan Joy C.
Published: October 2021

4H5.2, a 3-page factsheet by Marilyn N. Norman and Joy C. Jordan, explains how to properly establish, create and manage 4-H bank accounts. Includes information about obtaining an IRS Employer Identification Number. Published by the UF Department of Family, Youth and Community Sciences, February 2007.
Procedure for Handling 4-H Accounts: Guidelines for Fund-Raising
Authors: Norman Marilyn N. , Jordan Joy C.
Published: October 2021

4H5.5, a 4-page factsheet by Marilyn N. Norman and Joy C. Jordan, gives guidelines for properly conducting fundraising within 4-H. Published by the UF Department of Family, Youth and Community Sciences, February 2007.
Organic Greenhouse Container Herb Production in South Florida: Fertilizer and Potting Media
Authors: Migliaccio Kati W. , Olczyk Teresa , Qian Yun , Li Yuncong , Hochmuth George J. , Hochmuth Robert C. , Treadwell Danielle D. , Simonne Eric H. , Osborne Lance S. , Sprenkel Richard K.
Published: October 2021

ABE-373, a 6-page report by K. W. Migliaccio, T. Olczyk, Y. Qian, Y. Li, G. J. Hochmuth, R. C. Hochmuth, D. D. Treadwell, E. H. Simonne, L. S. Osborne, and R. K. Sprenkel, presents the results of trials conducted in 2005 and 2006 to compare organic fertilizers and potting media for greenhouse production of container herbs. Includes references. Published by the UF Department of Agricultural and Biological Engineering, May 2007.
ABE 373/AE408: Organic Greenhouse Container Herb Production in South Florida: Fertilizer and Potting Media (ufl.edu)
Redwi Danjé Nan Zòn Pòt
Authors: Knowles, III Hal S. , Ruppert Kathleen C. , Lenfesty Karla A. , Haldeman Barbara
Published: October 2021

Part of the Education + Action = Wind Damage Mitigation series by Kathleen C. Ruppert, Hal S. Knowles, Karla A. Lenfesty, and Barbara Haldeman that is now available in Spanish and Haitian Creole.
ABE378HAI/AE424: Redwi Danje Nan Zòn Pòt yo (ufl.edu)
¿Cómo El Viento Afecta Las Casas?
Authors: Ruppert Kathleen C. , Knowles, III Hal S. , Lenfesty Karla A.
Published: October 2021

This is part of the Education + Action = Wind Damage Mitigation series by Kathleen C. Ruppert, Hal S. Knowles, and Karla A. Lenfesty that is now available in Spanish and Haitian Creole
ABE379SPAN/AE426: ¿Cómo El Viento Afecta Las Casas? (ufl.edu)
Guía para Operadores Profesionales de Herbicidas para el Control del Árbol de Corteza de Papel (Melaleuca)
Authors: Langeland Kenneth A. , Meisenburg Michael
Published: October 2021

SS-AGR-258-S, a 5-page illustrated fact sheet by K.A. Langeland and Michael Meisenburg, is the Spanish language version of 'Professional Applicator's Guide to Herbicides for Melaleuca Control.' It provides professionals with information on using herbicides as part of an integrated management program for invasive melaleuca trees. It describes available herbicides and application methods and when each should be used. Published by the UF Department of Agronomy, November 2006.
Impact of Grazing Methods on Forage and Cattle Production
Authors: Vendramini Joao , Sollenberger Lynn
Published: October 2021

SS-AGR-133, a 5-page fact sheet by Joao Vendramini and Lynn Sollenberger, describes the advantages and disadvantages of rotational grazing vs. continuous grazing. Includes figures and references. Published by the UF Department of Agronomy, January 2007.
SS-AGR-133/AG268: Impact of Grazing Methods on Forage and Cattle Production (ufl.edu)
Total Protein Requirements of Beef Cattle I: Feed the Bugs First
Authors: Carter Jeffrey N.
Published: October 2021

AN167, a 2-page illustrated fact sheet by Jeffrey N. Carter, describes the role of beneficial microbes in the rumen of beef cattle which provide the primary source of protein for ruminant animals, microbial crude protein. Includes a line diagram depicting the path of dietary protein. Published by the UF Department of Animal Sciences, September 2006.
Florida Dairy Farm Situation and Outlook 2007
Authors: Giesy Russ , De Vries Albert
Published: October 2021

AN180, a 4-page report by Russ Giesy and Albert De Vries, is one of a series of annually published reports on the dairy industry in Florida, based on the results of a survey by the Dairy Business Analysis Program (DBAP). It includes discussion of the situation and outlook, as well as background information on the challenges facing the dairy industry in Florida: production, economic, environmental, and social.  Published by the UF Department of Animal Sciences, February 2007.