bluuebunny/crossref_metadata_2025 huggingface dataset:
Experience in using the RAPD-PCR technique for identifying E. coli strains in patients with urinary tract infections
Authors: Sursyakova K. , Safyanova T. , Prokopiev V.
Published: July 2020

Urinary tract infections (UTIS) in the Russian Federation are widespread and often occur in children, adults, most often affecting people in the most active period of their lives. The course of UTI is determined by a number of predisposing factors, such as age, sex, General condition of the patient, the presence of immunocompromising factors. Uncontrolled use of antibacterial therapy is often a predisposing factor in the chronization of the process in the upper urinary tract.To determine the identity of E. coli strains. In 2019, biological material was collected from 50 patients of «Altai regional hospital for war veterans» with urinary tract infections (chronic pyelonephritis and chronic cystitis) to assess bacteriuria. According to the results of bacteriological research, 23 strains of E. coli were isolated. After that, molecular genetic analysis was performed using the Random Amplified Polymorphic DNA method of E. Coli strains obtained from patients with urinary tract infections, and their identity was evaluated. The results of this study showed that the method used is a reliable method of epidemiological mapping and determination of relationships between closely related varieties and strains of microorganisms isolated from various sources. Carrying out one bacteriological examination of urine in urinary tract infections is not enough, only high-tech techniques allow establishing the exact type of the causative agent of these infections and will allow selecting the correct appointment of antimicrobial drugs in patients with this group of infections.
Assessment of professional risk of health of workers of the enterprise for repair of railway carriage
Authors: Klepikov O. , Boreyko A. , Kurenkova G.
Published: July 2020

The aim of the study was to assess the professional risk of developing diseases in workers of the railway car repair enterprise. The Voronezh Car Repair Plant, a branch of Vagonremmash Joint-Stock Company, was chosen as the object of study. Methods: «The methodology for calculating individual occupational risk depending on the working conditions and the health status of the employee», developed by the Klin Institute for Protection and Working Conditions in conjunction with the Research Institute of Occupational Medicine (2013), the main professions; cohort study with the calculation of the relative risk of morbidity with temporary disability, the odds ratio, the etiological share of factors in the formation of morbidity (group size: 250 people, experimental group — workers of the main specialties, 95 people — comparison group). Results. According to the research results, the priority factors of occupational health risk include: chemical, noise, heating microclimate, low light level. For certain professions, the share of the contribution of priority factors to the risk profile (PV) reaches 40 %. The indicator of individual occupational risk is 0.12 to 0.26 units. The high level of professional risk (0.22 ÷ 0.26) is characterized by the working conditions of the mechanics for the repair of rolling stock, machine tools (woodworking), casters (metal), thermists, plastic casters. In professional groups with medium and high risk, the indicator of the relative risk of morbidity with temporary disability is higher than 1 (RR = 1.75 and 1.39, respectively), and the etiological share of production factors in the formation of diseases is from 27.95 (subgroup with secondary professional risk) up to 42.88 % (a subgroup with high professional risk), which indicates the professional condition of the disease. Discussion. In general, our data are consistent with the results of similar studies conducted earlier at the car building and car repair enterprises. In order to ensure hygienically safe working conditions and preserve the health of workers, it is necessary to reduce the level of exposure to production factors, including through the introduction of modern equipment and improvement of technological processes.
Occupational malignant neoplasms in the enterprise workers in the Russian Arctic
Authors: Syurin S.
Published: July 2020

The purpose of the study was to investigate the risk factors, prevalence and structure of occupational malignant neoplasms (OMN) in the Arctic zone of Russia. Materials and methods. The monitoring data «Working conditions and occupational morbidity» of the population of the Arctic zone of Russia in 2007–2018 were studied. Results. It was established that in 2007–2018, the risk of forming OMN was created by dust aerosols and carcinogenic chemicals, as well as ionizing radiation. Their average annual shares in the overall structure of harmful production factors were 0.66 %, 1.10 % and 0.45 %. OMN (67 cases) developed mainly among male workers of non-ferrous metallurgy enterprises, miners of coal and copper-nickel mines (86.6 %) aged 51–60 years and with the experience of 21–30 years. The main risk factors were nickel compounds and, to a lesser extent, carbon and silicon dioxide dust, exposure to which arose due to imperfection of technological processes and sanitary installations, design flaws of machines and other equipment. The risk of OMN when exposed to chemical carcinogens was higher than to dust aerosols (RR = 3.64; CI 1.79–7.38).The typical localizations for neoplasms were the broncho-pulmonary system (56.7 %) and the stomach (23.9 %). In 2007–2011, the share of OMN in the structure of occupational pathology was 0.84 %, decreasing in 2014–2018 to 0.44 %. Conclusion. The priority in the prevention of cancer pathology in the Russian Arctic is to reduce the exposure of workers to nickel compounds by improving working conditions and personal protective equipment, especially for respiratory organs.
The development of information interaction as a key element of state risk management and health protection
Authors: Voronkova S.
Published: July 2020

The article discusses ways to obtain information about risk factors and the health status of the population. The article describes a new information system «labor Medicine», which allows to organize the collection of a wide range of data for further analysis and application in the activities of various Executive authorities, public organizations, foundations, legal entities and citizens. It is proposed to improve this system by expanding the types of information collected, creating a passport for health promotion organizations, as well as integration with systems that are being implemented in the Russian Federation for managing the health of the working-age population in the context of state policy in the field of Informatization.
Some aspects of Mycobacterium tuberculosis resistance to disinfectants in the focus
Authors: Asmanova Mariya , Lukyanenko Natalya , Lukyanenko Nikolay , Prokopyev Vasiliy
Published: July 2020

The article presents assessment of Mycobacterium tuberculosis resistance to disinfectants in the focus of the disease according to the results of microbiological examination of the material selected in Altai Regional Tuberculosis Dispensary in 2017-2019. Analysis of the examined mycobacterium resistant to disinfectants was multiple: resistance to disinfectants with different concentration, growth rate, bacterial excretion rate, comparison of the tuberculocidal activity of chloramine in archival and clinical strains with varying degrees of antibiotic resistance. The results indicated: dependence of M. tuberculosis resistance to disinfectants on weak concentration, duration of exposure and low efficiency of some disinfectants against Mycobacterium tuberculosis; higher bacterial excretion rate among resistant M. tuberculosis strains and growth rate among sensitive M. tuberculosis strains.
Intestinal microbiological landscape in workers of diverse agricultural sectors
Authors: Gizatullina L. , Masyagutova L. , Ivanova R.
Published: July 2020

The purpose of the work was to study the qualitative and quantitative intestinal microbial composition in agricultural workers, to identify dysbiotic disorders, the severity of dysbiosis and its specificities. The material for the study was feces after natural defecation. Agricultural workers were examined in inpatient care conditions. In 96.7 % of cases, intestinal dysbiosis characterized by a quantitative and qualitative change in the composition of microflora in the small and large intestines was diagnosed. To account for the results, each type of microorganism was counted in 1 g of feces according to the formula: M = N × 10n+1, where M is the number of microbes in 1 g, N is the number of grown colonies on a Petri dish, n is the degree of dilution of the material. The absolute values of the number of colony forming units (CFU) per 1 g of feces and decimal logarithms (Ig CFU/g) expressed the number of microorganisms. Lactobacillus deficiency was detected in 36.6 % of the examined, bifidobacteria deficiency was 97.0 %. The reasons for this effect on the normal intestinal flora can be various harmful environmental factors that could reduce a number of important functions in the body of a macroorganism.
Occupational risks related to the exposure of the noise and vibration factor on workers extracting fuel and nonfuel minerals. Preventive measures
Authors: Volgareva A. , Shaykhlislamova E. , Gimranova G. , Karimova L. , Muldasheva N.
Published: July 2020

Extraction of minerals with noise and vibration to be a priority harmful occupational factor, is one of the industries with a high risk of workers’ health, disorders. This is an occupational morbidity rate. In accordance with the regulatory and methodological documents, an assessment of the a priori and a posteriori occupational risks related to the impact of the noise-vibration factor was carried out for workers of the main occupations of the largest enterprises extracting fuel, energy and ore minerals of the Republic of Bashkortostan.An analysis of occupational health risks for workers has shown a rather high a priori risk, since the general hygienic assessment of working conditions is within the limits of Сlasses 3.2–3.4. Levels of occupational risk in accordance with occupational disease index ranged from «high» for vibrational disease in occupational groups of drifters, rig drivers, excavator drivers to «above average» for sensorineural hearing loss in installers, underground mining machine drivers, excavator drivers and aggregates. Based on the studies, measures have been developed aimed at reducing the levels of exposure to the noise-vibration factor and maintaining the health of workers engaged in mining.
Comprehensive diagnosis of fatigue in workers engaged in intense visual work
Authors: Bakutkin Valeriy , Bakutkin Ilya , Zelenov Vladimir
Published: July 2020

Diagnosis of fatigue in workers of visually intense work is an urgent problem, since their number is steadily increasing. A comprehensive technique has been developed, consisting of questionnaires with a point system for assessing the severity of symptoms, which is intended for the diagnosis and individual monitoring of fatigue of workers of visually intense work. The most common signs of fatigue in workers of visually intense work is a symptom complex, disturbances in accommodation, headaches, and visual impairment. A computer program for analyzing the blinking frequency has been developed, which is an objective, sensitive method for diagnosing and monitoring fatigue in workers of visually intense work. The compensatory stage is characterized by transient changes in visual functions and the rapid elimination of symptoms during rest. With subcompensation, preventive and therapeutic measures are required. Signs of decompensation are persistent changes in visual functions, which lead to the formation of refractive and accommodation disorders, which are the cause of partial disability.
Study of the infl uence of information and communication tools on the psychophysiological state of schoolchildren on the basis of subjective evaluation
Authors: Rakhmanova Aleksandra , Loginov Georgiy , Dolich Vladimir , Komleva Nataliya , Rakhmanova Galina
Published: July 2020

The relevance of the article is determined by the existence of contradictions between the need to introduce innovative technologies into the educational process at school, as an integral attribute of modern education, and the negative influence of factors on the physical and psycho-emotional state of health of students related to the use of information and communication tools (computers, phones, headphones). The goal of the study was to assess the relationship between the timing of the use of information and communication tools and the frequency of functional and psycho-emotional complaints in groups of middle and high school schoolchildren. 400 schoolchildren of the Saratov Region, the Moscow Region, Leningrad Region and the Republic of Dagestan were surveyed, who made up two groups of research: middle-school schoolchildren (grades 5–6) and high-school schoolchildren (grades 10–11 The survey was carried out by means of the standardized formalized cards which included the questions considering usage time of computers and mobile phones, complaints to a headache, hands pain, other pain and/or feeling of discomfort from visual organ and the organs of hearing, as well as a psycho-emotional state. Statistical analysis of the data was performed using the STATISTICA application software program by StatSoft Inc (USA). To compare the frequencies of a binary feature, a fourfold table of absolute frequencies was constructed and the level of statistical significance for the exact Fisher’s two-tailed test criterion was determined. The study was conducted according to the requirements of bioethics, after signing informed consent statement by teenagers and their parents. The study examined the relationship between the timing of the use of information and communication tools and the frequency of complaints in groups of schoolchildren. The results of the study should be taken into account when developing and implementing preventive measures to prevent negative effects of computers and mobile devices on the body of students.
Assessment of nutritional status of students of medical institute according to the blood biochemical parameters
Authors: Rakhmanov Rofail , Bogomolova Elena , Shaposhnikova Mariya , Sapozhnikova Mariya
Published: July 2020

The biochemical blood parameters characterizing the students ’nutritional status were evaluated: protein, lipid, carbohydrate metabolism, a number of minerals. The mean values, errors of the mean, median (Me), boundary (Q) and the range of 25–75 percentiles were determined. In 9.1 % of students and 28.6 % of students, the total protein was increased. Creatinine in men was in the upper normal range, in women — at the upper limit of normal, of which 46.2 % was higher than normal. The interval Q25–75 of uric acid in students is determined in the lower normal zone. In 40.0 % of men, decreased high-density lipoprotein cholesterol (Q25–75 corresponded to 1.15–1.79), in women — below normal, Q25–75 5 was 1.3–1.5, decreased in 73.3 %. Me and Q25–75 iron were in the lower normal range; 14.1 % of men and 13.2 % of women are below normal. Me sodium and potassium at the level of the lower boundary of the norm, Q25–75 in the lower zone of the norm: in 16.0 % and 15.4 % of students the levels are reduced. Calcium is slightly above the lower limit of the norm, Q25–75–2.1–2.24, indicating an insufficient intake in the whole group; 25.0 % are below normal. The border of the 25th percentile of magnesium is at the level of the lower border of the norm, in 19.2 % it is reduced. 7.2 % lack of chlorine. Phosphorus is normal, but Q25–75 is in the upper zone; 17.9 % increased. Biochemical markers can identify individuals with metabolic disorders of nutrients. Statistical indicators — the median, the boundaries of 25–75 quartiles and their scope characterize the metabolism of macronutrients and minerals in the group and subgroups of students. Laboratory and mathematical methods can provide a basis for identifying the specific causes of these changes. For this, you can use the questionnaire method of studying the nutrition of students, possibly using the developed questionnaires for a specific situation.
Non-hormonal drugs in the treatment of mastopathy
Authors: Musina Ekaterina
Published: July 2020

Mastopathy is one of the most common diseases affecting the mammary gland. This term is used to describe a number of morphological changes that are accompanied by clinical symptoms. Cyclical vitamin therapy used by gynecologists for several years is widely applied at present. The next direction in the comprehensive treatment of mastopathy includes various dietary recommendations, such as limiting fat intake and expanding consumption of fiber-rich products with food. Non-hormonal drugs used to correct mastopathy, including vitamins and herbal remedies, can lead to a pronounced positive effect in relation to the clinical symptoms of the disease.
Floppy baby syndrome
Authors: Panchenko Sergey
Published: July 2020

Issue of clinical polymorphism is especially important in the diagnosis of conditions that are clinically manifested by the complex of symptoms of a «floppy baby». It is not a separate nosological form, its clinical features are not specific, the course and outcome are variable. Diffuse muscular hypotonia can be a sign of a large number of somatic and neurological diseases, in particular, hereditary metabolic diseases and degenerative diseases of the nervous system. According to the level of damage, it can be classified into hypotonia of central and peripheral origin. Their differential diagnosis is carried out according to a number of criteria. Differences in treatment tactics and prognosis of opportunities during inclusion period determine importance of topical diagnosis of the degree of damage. Timely determination of this syndrome in a child allows to start searching for the causes of this condition and comprehensive treatment.
Fever in children
Authors: Vangizon Petr
Published: July 2020

Every child has a fever — high temperature — at least once a year. There is still an opinion among parents about the extreme danger of fever, so they immediately try to bring it down, even if it is under 38 °C. Fever firmly holds the primacy in the list of symptoms when pharmacological treatment is prescribed. And doctors, wanting to alleviate condition of the child, and most importantly, trying to prescribe treatment the effect of which will be immediately visible, also often resort to the prescription of antipyretic drugs that is not always justified.
Infusion therapy in newborns
Authors: Marchenko Ekaterina
Published: July 2020

Infusion therapy during the neonatal period is prescribed if it is not possible to start enteral nutrition for infant (breast milk/formula) or if it is necessary to maintain (correct) concentration of glucose and/or electrolytes. The main objective of infusion therapy is to maintain the proper volume of extracellular fluid. For adequate infusion therapy, it is necessary to determine physiological needs for fluids, calculate pathological losses, choose a solution for infusion therapy, calculate the amount of electrolytes administered, and determine the rate of infusion. Despite the fact that infusion therapy has been used widely and for a long time, there are still many unresolved issues, and the main ones are still «When?», «What?» and «How much?»
Dental care for pregnant women
Authors: Klimov Vladimir
Published: July 2020

Pregnant women are at risk for the development and progression of major dental diseases — caries and periodontal diseases. Dental pathology in pregnant women affects development of the fetus. An urgent task is to develop an algorithm for the effective and safe treatment of dental diseases in women at different stages of pregnancy, which will increase the level of effectiveness and safety of dental care provided by dentists of health care institutions of various forms of ownership.
Features of Chinese health care system
Authors: Frolova Elena
Published: July 2020

Not so long ago, one well-known title published a rating of countries according to the degree of their influence on geopolitics. The United States, which took the first place, entered the top three with Russia, which was ranked the second, and the third place in the rating was confidently taken by China. The Chinese have made a huge breakthrough in the field of economics and politics over the past 20 years, they have been able to successfully take strong positions in global business and entrepreneurship, and in many areas of life they dictate their own rules. If we take into account the fact that almost every fifth inhabitant of the planet is Chinese, it becomes clear that this country forms certain trends in the medical sphere.
February 9 — Dentist Day in Russia
Authors: Rybachok Oksana
Published: July 2020

«Man is what he eats,» these words belong to the great Pythagoras. He meant by these words the connection of the origin of consumed food with the spiritual development of man. In fact, a lot depends on the nature of nutrition, the quality of food and, of course, on the degree of its perception by the body. Digestion process begins not in the stomach, but directly in the oral cavity as a result of mechanical processing of products with teeth and under the influence of the secretion of the salivary glands. That is why healthy teeth are the key to the normal functioning of the whole organism — people should start taking care of their teeth from the early childhood and dentists, who are far from being beloved by everybody and are often carelessly evaded, are called upon to help keep the teeth healthy.
Clinical symptoms in rheumatology
Authors: Kochiyeva Marina
Published: July 2020

Rheumatology is one of the areas of internal medicine that deals with the diagnosis and treatment of rheumatic diseases. The term rheumatology is based on the merger of the words «rheuma», which means «flowing current», and «logos», which means «studies». Thus, the subject of the rheumatology study is inflammatory and degenerative-dystrophic diseases affecting the joints, as well as systemic diseases of the connective tissues (the outdated name is collagenosis). Diversity and polymorphism of the clinical symptoms of connective tissue diseases often leads to the difficulties in diagnosis and timely treatment.
Hemolytic uremic syndrome associated with pregnancy
Authors: Klimov Vladimir
Published: July 2020

Atypical hemolytic uremic syndrome (aHUS) in 12-31% of cases is associated with pregnancy or childbirth and can determine the prognosis of both the mother and the child. In recent years more attention in obstetric practice has been paid to thrombotic microangiopathy (TMA) as one of the most serious complications of pregnancy. Despite the fact that during pregnancy TMA rarely develops (TMA in obstetrics accounts for 8-18% in the structure of all forms of TMA), high risk of pre-eclampsia, maternal and perinatal mortality, unfavorable "renal prognosis" associated with this pathology, determine the relevance of studying this problem.
The worst epidemics in human history
Authors: Sakhno Natalya
Published: July 2020

Today the world's attention is focused on China, on the epidemic caused by coronavirus infection. As of the end of February, more than 77 thousand people affected with the disease had been registered, fatal outcome had been observed in more than 2500 cases. The Chinese authorities announced the beginning of a new epidemic at the very end of 2019. Moreover, if fatal outcomes were observed a month after the onset of mass incidence only within the country, then, in February, they went beyond its borders and were registered in Japan, Taiwan, South Korea, Iran, the Philippines, France and Italy. It is noteworthy that China became a source of the spread of the epidemic process not for the first time. So, in 2002 it was in this country, in Guangdong, that an outbreak of SARS was recorded, and in 1997, avian influenza spread from Hong Kong around the world. To tell the truth, the death rate from these diseases did not exceed thousands of people in both cases, and in the case of bird flu (or avian influenza), development of the disease was observed only in people eating chicken meat. It should be noted that in the entire history of the development of mankind, more people died as a result of epidemics and pandemics, than in all wars combined. Let us recall the worst epidemics in the history of mankind, the victims of which were millions of people.
Health care in South Africa
Authors: Frolova Elena
Published: July 2020

Every person who is at least somewhat familiar with the history of medicine knows the name of Christiaan Barnard, cardiac surgeon who performed the first successful heart transplant. This happened on December 3, 1967 at a hospital in Cape Town, South Africa. A man suffering from an incurable heart disease had a healthy organ transplant from a 25-yearold girl who died in a car accident. The patient lived for two weeks and died from complicated bilateral pneumonia, however, this case marked the beginning of a new era in transplantology giving hope of saving hundreds of patients. What do we know about health care of the Republic of South Africa, one of the most developed countries on the African continent? How much does the present situation allow the government to be classified as a world leader in healthcare? Unfortunately, according to the World Health Organization newsletter, South Africa at the present stage tops the sad ranking of countries by the number of HIV-infected and AIDS patients — about 7 million out of the 58 million people are infected with a dangerous virus. Unlike developed countries, where the main cause of death is pathology of the cardiovascular system, strokes and malignant neoplasms, three quarters of patients in the Republic of South Africa die due to infectious processes. Speaking about the heterogeneity of medicine, we were almost for the first time confronted with the fact that health services can be divided not only into health care for the «rich and poor», but also for the «white and black».
Role of genetic factors in the development of hypertension in young patients with metabolic syndrome
Authors: Korneeva Elena , Voevoda Mikhail , Semaev Sergey , Maksimov Vladimir
Published: July 2020

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).
New approaches to managing patients with hypertensive crisis (sudden increase in blood pressure)
Authors: Krayushkin Sergey , Ivakhnenko Irina , Kolesnikova Irina
Published: July 2020

The article discusses management tactics for patients with hypertensive crisis – a sudden increase in blood pressure, which is based on the assessment of end-organ damage. In the presence of acute end-organ damage, condition is defined as hypertensive crisis and requires immediate intensive care. In this case, intravenous administration of drug is necessary, the choice of which depends on the type of end-organ damage. Gradual decrease in blood pressure and selection of long-term antihypertensive therapy on an outpatient basis is recommended for patients with hypertensive crisis without acute end-organ damage.
Healthcare in Greece
Authors: Frolova Elena
Published: July 2020

What do we know about Greece, except that it is a country where "there is everything"? Unfortunately, financial crisis of the beginning of the 2000s painfully hit not only the Greek economy, but also affected many other areas, including healthcare. Up until recently, the Greek health care system occupied one of the last places among European countries, and it was the former Ancient Greece that gave humanity God Asclepius, better known as Aesculapius. According to the legend, Apollo killed Coronis who was pregnant with the future healer, removed from her womb the baby, whom they called Asclepius, and entrusted him to Chiron, the centaur, for training. It is believed that it was Chiron who taught the boy the art not only of healing people, but even resurrecting the dead. Temples of Asclepius were called Asclepions, they became the prototypes of future hospitals. The sick and wretched came to these temples so that the clergymen would give them healing. It was believed that if you leave the patient in Asklepion at night, Hygieia (later the patroness of “hygiene”) and Panacea (the term “panacea”, which means a cure for all diseases), daughters of Asclepius, will come there at night. And if at first the servants of God really tried to save the afflicted only by reading prayers, then later they began to apply herbal medicine, massage, water procedures, diet, and at a later stage even perform surgical interventions. One of the most famous followers of Asclepius was Hippocrates, whose name is associated with the emergence of medicine as a separate science [2]. It was he who first made the assumption that most diseases are of natural origin and are associated with the influence of external factors, and they are not a “God's punishment,” as it had been previously believed.
Organization of restrictive quarantine measures to prevent especially dangerous infections
Authors: Ilyin Petr
Published: July 2020

Especially dangerous infections (EDIs) belong to the conditionally labelled group of infectious diseases that pose an exceptional epidemic threat. They are highly contagious, rapidly spreading and capable of affecting wide sections of the population in the shortest possible time, they are characterized by the severity of clinical symptoms and high mortality rates. At the present stage, the term "especially dangerous infections" is used only in the territory of the countries of the former USSR, all over the world this concept is defined as "infectious diseases that pose an extreme threat to public health on an international scale." Over the entire history of human development, more people have died as a result of epidemics and pandemics than in all wars combined. The list of especially dangerous infections and measures to prevent their spread were fixed in the International Health Regulations (IHR), adopted at the 22nd session of the WHO's World Health Assembly on July 26, 1969. In 1970, at the 23rd session of the WHO's Assembly, typhus and relapsing fever were excluded from the list of quarantine infections. As amended in 1981, the list included only three diseases represented by plague, cholera and anthrax. However, now annual additions of new infections endemic to different parts of the earth to this list take place. To date, the World Health Organization (WHO) has already included more than 100 diseases in the list of especially dangerous infections.
On the issue of assessing quality of life of patients with sensorineural hearing loss
Authors: Zhuravlev Anton
Published: July 2020

The article provides an overview and comparison of methods for assessing quality of life of patients with hearing impairment. One of the main indicators of the level of the state development at the present stage is the quality of life of its citizens. Even now there are some discrepancies in assessing the quality of human life in the scientific literature. Moreover, selection of objective, "measurable" criteria (such as level of educational, indicators of financial well-being, assessment of housing conditions, structure of nutrition, health care availability, etc.) does not fully reflect the multicomponent concept of quality of life and requires additional for subjective criteria for the assessment system – characteristics of physical, mental and social well-being based on subjective perception and self-rating of a person. Systems medical and sociological research of the quality of human life can provide significant assistance in the formation of an objective understanding concerning specifics of social burden of sensorineural hearing loss.
Dengue fever
Authors: Korobka Yuriy
Published: July 2020

Dengue fever (other names: breakbone fever, vomiting and dandy fever) is a mosquito-borne viral infection, which in its course resembles the flu, but in some cases can be fatal. It should be noted that in recent years there has been an increase in the incidence of this infection. Most often, Dengue fever develops in the conditions of the tropics and subtropics, and, as a rule, affects residents of towns and suburban areas. In some Asian and Latin American countries, this disease even comes out on top for reasons of mortality. There is no specific treatment, but a timely diagnosis and timely treatment will contribute to a significant reduction in mortality rate.
Oncology and pregnancy
Authors: Klimov Vladimir
Published: July 2020

Cancer and pregnancy are one of the most complex and controversial issues in oncology. This applies both to the clinical manifestation of the malignant process during pregnancy and pregnancy in a patient who has previously undergone treatment for a tumor. In both cases, medical, social, and ethical issues are closely intertwined.
Differential diagnosis of urinary syndrome
Authors: Karapetyan Ashot
Published: July 2020

The article presents the clinician's view on general diagnostic and differential diagnostic approaches when analyzing data of the urine test in patients with nephrological, therapeutic and urological pathology. Features of the urinary syndrome are examined in detail depending on the presence, degree and severity of haematuria, leukocyturia, proteinuria, cylindruria in various diseases. Moments of diagnosis and clinical examination of patients with urolithiasis, kidney and urinary tract tumors, urinary tract tuberculosis, renal vascular anomalies, cystic dysplasia, and nephroptosis are described in detail in addition to traditional chronic kidney diseases (glomerulonephritis, pyelonephritis, interstitial nephritis).
Forewarned is forearmed. How important testing for coronavirus is
Authors: Skvortsov Vsevolod
Published: July 2020

Today the coronavirus topic does not leave the pages of newspapers and TV screens, we are horrified by the events in Italy and applauding the Chinese doctors who went to this country to help. In the conditions of the current situation everyone has a question, «How high is risk of getting coronavirus for me, do I pose a threat to my family members?» It is quite natural that someone wants to be examined without waiting for the onset of symptoms of the disease, while others, on the contrary, refuse to be examined and quarantined, even if they got sick. We propose to consider today in the article how important testing coverage of wide sections of the population is, and how this ultimately affects development of the epidemic situation in the country.
The effectiveness of the inclusion of spatially oriented motor therapy in comprehensive rehabilitation programs for patients with spastic hemiparesis after stroke
Authors: Koneva Elizaveta , Shapovalenko Tatyana , Konstantin Lyadov , Timashkova Galina , Achkachov Evgeny , Sultanova Olga , Mikhailova Anna
Published: July 2020

The aim of the study — the evaluation of the effectiveness for restoring the functional abilities with Neurac method in patients undergoing stroke. Materials and methods. The study included 20 participants, they were divided into 2 groups, the first group — the patients who undergoing the stroke (main group): the main group of patients received a base standard rehabilitation program (kinesiotherapy, mechanotherapy on cyclic apparatгs, massage) and additional trainings in Redcord in Redsord system. The control group — a base standard rehabilitation program. The duration of the rehabilitation course was 14 days. Results and consideration. As a result of the study in both groups (main and control) as compared with the initial findings were better results of Berg Balance Test: 44,4±0,5 in the first group and 43,6±0,8 in the second group vs. 48±0,3 and 45,3±0,5 (р≤0,05). Although in patients of the first group after restoring treatment course with using method of Neurac method it was authentic lesser disturbance of everyday life activity: in estimating Bartel Index 86,9±0,5 vs. 80,1±0,7 (initial) (р≤0,05), what was significantly higher be comparison with control group results. In estimating 10 minutes walking test: 16,82±5,4 in the main group 2020 2 vs. 22,6±3,33 (initial) (р≥0,05), what was although significantly higher in comparison with the second group. By estimating walking on C-mill treadmill the middle speed in first and it second groups was 0,90±0,1 vs. 0,84±0,3 with 0,80±0,2 vs. 0,84±0,3 (ibitial) (р≥0,05). Conclusion: the obtained results point at the effectiveness of using Neurac method in restoring treatment programs for patient undergoing stroke for elevation of the stabilization of trunk, improvement of balance (in static, in functional movements, in walking), independence level in real life terms. An additional point is that this kind training can promote significantly positive influence on the patient’s motivation for actualization of active movement to improvement of the social and domestic adaptation, increase of motor and functional abilities.
Application of therapeutic complex with cytoflavin pills, transcranial electrostimulation and magnetic-laser therapy in patients with vertebrobasilar insufficiency
Authors: Klocheva Elena , Shiman Alfred , Shoferova Svetlana , Shiman Lyudmila , Marchenkova Mariya
Published: July 2020

An examination and treatment of 120 patients with circulatory failure in the vertebral-basilar basin was carried out. We studied the hemodynamic state of arterial and venous cerebral blood flow (ultrasound, magnetic resonance angiography, phlebography). We evaluated the dynamics of subjective and objective clinical, hemodynamic parameters before treatment and against the background of the combination therapy. The high efficiency of the influence of the treatment complex with the use of cytoflavin in tablets, transcranial electrical stimulation, magnetolaser effects on the dynamics of clinical and functional indicators, and a reduction in hospital stay in patients with circulatory failure in the WB has been shown to be highly effective.
Effectiveness of incorporating the biofeedback technique — video reconstruction into comprehensive rehabilitation programs for elderly patients
Authors: Koneva Elizaveta , Shapovalenko Tatiyana , Lyadov Konstantin , Mikhailova Anna , Korchazhkina Natalia , Tolstykh Natalia , Achkasov Evgeny , Sultanova Olga
Published: July 2020

Objective: to conduct a comparative analysis of the effectiveness of hardware balance training in elderly patients in order to improve coordination, postural control and improve mobility. The study included 40 participants, over the age of 70 years. All patients were divided into 2 groups: patients in the control group received a standard rehabilitation program: classes in therapeutic gymnastics with an instructor of exercise therapy, massage. In addition to routine methods, patients of the main comparison group underwent training on the CMill dynamic balance training hardware device. The duration of the rehabilitation course was 10 days. As a result of the study, in patients of the main group, compared with the control control group, a significant improvement was noted in 21 out of 33 analyzed podometric indicators of the dynamic walking stereotype. The results of the effective use of the apparatus balance training method indicate the prospect of including this technology in the rehabilitation programs of elderly patients to improve the dynamic stereotype and increase stability while walking.
The effect of the presence of the metabolic syndrome on the efficiency narrow-band uvb ultraviolet radiation (311) in patients with psoriasis
Authors: Dmitruk Vadim , Khardikova Svetlana , Gerasimenko Marina , Evstigneeva Inna , Zaitseva Tatiana
Published: July 2020

Backgraund: the researchers explain the high prevalence of metabolic syndrome among patients with psoriasis by the development of systemic infl ammation, which is considered as a single pathogenetic mechanism in these pathological conditions. The response of patients with psoriasis with metabolic syndrome to treatment with narrowband therapy is currently insuffi ciently studied. Aims: the study evaluated the effi cacy of narrowband therapy (311 nm) in patients with psoriasis associated with metabolic syndrome. Materials and methods: an objective and instrumental examination was conducted in 72 patients diagnosed with psoriasis vulgaris, after which a course of 20 procedures of narrow-cavity medium-wave ultraviolet irradiation (UFO) with a wavelength of 311 nm (B) was conducted. Patients were divided into 2 groups: patients with psoriasis and patients with psoriasis combined with metabolic syndrome. To assess the eff ectiveness of treatment, the index of the area and severity of psoriasis (PASI), lipid and carbohydrate metabolism; insulin and leptin; proinfl ammatory cytokines —IL-1β, IL-8, TNF-α and anti-infl ammatory cytokine IL-10 before and after the 10th, 20th procedure of UV-B therapy and 3 and 6 months after treatment. Results: а signifi cant decrease in PASI was observed in all patients with psoriasis after 10 procedures of UV-B therapy, but in the group of patients with metabolic syndrome, the PASI index was higher. After 20 procedures, Pasi reduction by more than 50 % was observed in the group of patients with psoriasis without manifestations of metabolic syndrome (р < 0,001). Indicators of lipid and carbohydrate blood metabolism in MS patients decreased (р < 0,05), the eff ect remained up to 6 months. The level of proinfl ammatory cytokines was increased in both groups, but in the group of patients with MS these indicators were higher. In the course of therapy cytokines decreased in both groups, the eff ect was maintained up to six months. On the contrary, IL-10 was reduced in both groups, and increased after our treatment, with the prolongation of the eff ect to 6 months. Conclusions: the appointment of UV-B therapy (311 nm) in patients with psoriasis with metabolic syndrome reduces the eff ectiveness of the course in the long term, which apparently requires repeated courses of narrowband therapy after 6 months.
Direct transcutaneous electroneurostimulation in the treatment of pathologies of the peripheral nervous system
Authors: Al-Zamil M. , Kulikova N. , Minenko I. , Vasilieva E.
Published: July 2020

This review of the literature presents the main directions of transcutaneous electroneurostimulation in medicine. The main stages of the development of TENS are described in detail from the moment of confi rmation of the pathogenetic basis of this method to the achievements of the latest discoveries in this branch. The main experimental data showing the advantage of using direct TENS compared to indirect TENS and the stages of developing and optimizing the clinical use of a new treatment method (direct TENS) in the treatment of pathologies of the peripheral nervous system are also given.
Modern capabilities for prognosis of postoperative complications in patients with colorectal cancer
Authors: Rodoman G. , Gendlin G. , Malgina N. , Dolgina T.
Published: July 2020

The article discusses the most frequently used prognostic scales intended to assess the risk of cardiac complications in surgical patients. The choice of optimal point scales for patients with colorectal cancer is justified.
Therapeutic drug monitoring (TDM) in treatment of a pregnant for 34 weeks with a diagnosis of gangrenous appendicitis, peritonitis
Authors: Zyryanov Sergey , Bondareva Irina , Kazanova Aleksandra , Ivzhits Marina , Chenkurov Mikhail , Kopaylo Arina
Published: July 2020

This article describes the clinical case of acute gangrenous appendicitis in a pregnant woman, followed by antibiotic therapy with meropenem dose of 2 g I. V. q8h with therapeutic drug monitoring (TDM) management. Therapeutic drug monitoring may be helpful for special patient populations with large pharmacokinetic variability, which include pregnant women. The goal of therapeutic drug monitoring is to increase the effectiveness of therapy by adjusting the dose and dosage regimen, as well as reducing the likelihood of side effects.
Experience of using atraumatic ointment bandages based on peruvian balsam in the complex treatment of patients with chronic wound defects of the lower limbs
Authors: Tabuika Anna
Published: July 2020

The article reflects the results of a retrospective non-comparative study, the objects of which were 34 outpatient comorbid patients (15 of which are over 60 years old) with chronic wounds of the lower limbs developed against the background of varicosity, post-thrombotic disease, chronic arterial insufficiency of the lower limbs, diabetes mellitus or their combination. Their local treatment was carried out using atraumatic ointment dressing «Branolind N» containing Peruvian balsam. There were 23 women (67.6 %) and 11 men (32.4 %). In microbiological study prior to the beginning of treatment in 31 patients the growth of a pathogen of wound infection was revealed; in 19 patients — Staphylococcus aureus in monoculture and in various associations, in 6 patients — Pseudomonas aeruginosa in monoculture, in other cases — other pathogens. In 3 patients the pathogen was not detected. The average wound size was 34 cm2 . The phase of the wound process was additionally confirmed by cytological studies. After treatment the average area of the wound defect decreased by 10 cm2 and made 24 cm2 on average. Full healing of the wound defect occurred in 11 patients, the others had granulation and active marginal epithelization. There was also a decrease in bacterial semination of wounds, a change in composition of infection agents to less aggressive monoflora, and cytologically — a decrease in signs of inflammation against the background of significant activation of reparative processes.
First experience of intraductal photodynamic Klatskin tumor therapy by using SpyGlass ™ DS technology in Russia
Authors: Artemkin Eduard , Kryukov Evgeniy , Ovsyannikova Maria , Sokolov Alexey , Sokolov Dmitry , Tychinskaya Ksenia , Kelzin Aleksey
Published: July 2020

The bile duct tumors diagnostics is very challenging due to the long asymptomatic course of the disease, complexity of early diagnosis and morphological verification of oncological process. In the vast majority of cases, the development of obstructive jaundice and the absence of pain syndrome are the only reasons that make it possible to suspect intraductal cholangiocarcinoma. CT, MRI and US examinations make it possible to suspect the localization of the tumor process in proximal regions and confluence of bile ducts. Morphological confirmation of the diagnosis can be obtained by performing a blind biopsy during ERCP and by performing intraoperative or oral cholangioscopy. The results of Klatskin tumor surgical treatment are unsatisfactory and tend to have high mortality rates. Chemotherapy and radiotherapy also do not meet the modern requirements of treatment. Oral cholangioscopy makes it possible to differentiate genesis of extrahepatic bile duct strictures with high accuracy, to perform targeted biopsy and to conduct a photodynamic therapy, which has shown high efficiency according to foreign studies. It the first time in Russia the authors have applied photodynamic therapy method using digital video choledochoscope of SpyGlass™ DS technology to treat a patient with Klatskin tumor.