bluuebunny/crossref_metadata_2025 huggingface dataset:
The potential of Terminalia chebula in alleviating mild cognitive impairment: a review
Authors: Gao Huimin , Lu Hanyu , Fang Nengqiao , Su Jinsong , Li Rui , Wang Wenjun , Zhang Yi
Published: October 2024

Terminalia chebula Retz. (T. Chebula, ཨ་རུ་ར།) is highly utilized in ethnic medicine. Its medicinal value is gradually being recognized and shows great potential in the improvement of mild cognitive impairment (MCI) disorders. Tibetan medicine theory classifies this type of disease as one of the “Jie Xie Syndrome (བརྗེད་བྱེད།).” The role of T. Chebula in such diseases has been increasingly studied. This work aimed to elucidate the research progress of T. Chebula in alleviating MCI. The review offers a critical update on the current understanding of the effect of T. Chebula on MCI and highlights new opportunities for exploring its therapeutic potential. This review discusses the role of T. Chebula in alleviating MCI and provides a comprehensive overview of the traditional medicinal uses, chemical composition, toxicology, and quality control aspects of T. Chebula. This review covers 171 chemical constituents and 11 active constituents targeting MCI, such as flavonoids, which can alleviate MCI, primarily through its antioxidative, anti-inflammatory, and neuroprotective properties. T. Chebula shows potential as a natural medicine for the treatment and prevention of MCI. As an important part of ethnomedicinal resources, this work offers valuable insights for future research on T. Chebula-containing ethnomedicines. Research on traditional drug treatments, optimized treatment standards, improved societal knowledge about MCI, and development of an early detection system is essential to the diagnosis and treatment of MCI. These efforts will provide better treatment resources for patients with MCI.
Towards full autonomous driving: challenges and frontiers
Authors: He Wei , Chen Wenhe , Tian Siyi , Zhang Lunning
Published: October 2024

With the rapid advancement of information technology and intelligent systems, autonomous driving has garnered significant attention and research in recent years. Key technologies, such as Simultaneous Localization and Mapping (SLAM), Perception and Localization, and Scene Segmentation, have proven to be essential in this field. These technologies not only evolve independently, each with its own research focus and application paths, but also complement and rely on one another in various complex autonomous driving scenarios. This paper provides a comprehensive review of the development and current state of these technologies, along with a forecast of their future trends.
Heart-lung crosstalk in acute respiratory distress syndrome
Authors: Rocha Nazareth N. , Silva Pedro L. , Battaglini Denise , Rocco Patricia R. M.
Published: October 2024

Acute Respiratory Distress Syndrome (ARDS) is initiated by a primary insult that triggers a cascade of pathological events, including damage to lung epithelial and endothelial cells, extracellular matrix disruption, activation of immune cells, and the release of pro-inflammatory mediators. These events lead to increased alveolar-capillary barrier permeability, resulting in interstitial/alveolar edema, collapse, and subsequent hypoxia and hypercapnia. ARDS not only affects the lungs but also significantly impacts the cardiovascular system. We conducted a comprehensive literature review on heart-lung crosstalk in ARDS, focusing on the pathophysiology, effects of mechanical ventilation, hypoxemia, and hypercapnia on cardiac function, as well as ARDS secondary to cardiac arrest and cardiac surgery. Mechanical ventilation, essential for ARDS management, can increase intrathoracic pressure, decrease venous return and right ventricle preload. Moreover, acidemia and elevations in transpulmonary pressures with mechanical ventilation both increase pulmonary vascular resistance and right ventricle afterload. Cardiac dysfunction can exacerbate pulmonary edema and impair gas exchange, creating a vicious cycle, which hinders both heart and lung therapy. In conclusion, understanding the heart-lung crosstalk in ARDS is important to optimize therapeutic strategies. Future research should focus on elucidating the precise mechanisms underlying this interplay and developing targeted interventions that address both organs simultaneously.
Exploring motivational patterns in high-performing pianists: evidence from Cliburn competitors’ biographies
Authors: Chen Xiao
Published: October 2024

This research examines the motivational patterns of high-performing classical pianists, characterized by a combination of implicit motives (i.e., non-conscious preferences for specific incentives). Utilizing the Linguistic Inquiry and Word Count (LIWC) software, I analyzed textual data from biographies of 107 pianists (i.e., Juniors aged 13–17: n = 38; Professionals aged 18–30: n = 30; Amateurs aged 35 and older: n = 39) participating in the prestigious 2022–2023 Van Cliburn Competitions. My results showed distinct profiles of implicit motives among pianists compared to non-pianists, with significantly higher need for achievement and need for power. While professional pianists exhibited the lowest level of need for power, junior pianists demonstrated the highest level of need for affiliation. Gender and age predicted part of pianists’ implicit motives. Male pianists demonstrated higher need for achievement than females. Finally, age negatively predicted need for affiliation. These findings highlight the motivational patterns within the classical piano community, offering theoretical implications for understanding implicit motives and practical applications for pianist education. Study limitations and future research directions are discussed.
Factors associated with perceived social support among adolescents in Gamo Zone, Southern Ethiopia: a community-based cross-sectional study
Authors: Sidamo Negussie Boti , Kerbo Amene Abebe , Wado Yohannes Dibaba , Koyira Mengistu Meskele , Gidebo Kassa Daka
Published: October 2024

Introduction

Perceived social support plays a crucial role in adolescent development, health, well-being, and resilience. Understanding the factors associated with perceived social support among adolescents is essential for designing effective interventions. However, research in this area, particularly within specific contexts, remains limited. Therefore, this study aims to identify the factors associated with perceived social support among adolescents in the Gamo Zone, South Ethiopia Regional State.

Method

A community-based cross-sectional study was conducted, involving 1172 adolescents selected through a stratified multi-stage sampling method. Structured face-to-face interviews were employed for data collection. Summary statistics were utilized for data presentation. Multiple linear regressions were then performed to identify factors associated with perceived social support. The strength and direction of associations were presented using β coefficients and 95% confidence intervals (CIs). The level of statistical significance was set at alpha 5%.

Result

The total mean for perceived social support among adolescents was 57.02 ± 12.68. Adolescents living with their biological parents reported significantly higher levels of perceived social support (β = 4.17, 95% CI: 2.00 to 6.34) compared to their counterparts. Similarly, adolescents engaged in paid work within the last 12 months reported higher perceived social support (β = 3.43, 95% CI: 1.39 to 5.46). Higher levels of parental monitoring were also associated with increased perceived social support (β = 3.03, 95% CI: 1.23 to 4.82). Additionally, adolescents who perceived risks for sexual and reproductive health (SRH) problems reported higher levels of perceived social support (β = 2.76, 95% CI: 0.84 to 4.69). Moreover, adolescents with good knowledge about SRH rights exhibited increased perceived social support (β = 2.46, 95% CI: 0.89 to 4.02). Furthermore, adolescents residing in rural areas reported higher levels of perceived social support compared to those in urban areas (β = 1.56, 95% CI: 0.16 to 3.11).

Conclusion

The findings of this study reveal that factors such as living arrangements, employment status, parental monitoring, perceived risks for SRH problems, knowledge about SRH rights, and geographical context emerged as important predictors of perceived social support. Therefore, implementing interventions and initiatives to address these identified factors holds promise for nurturing resilient adolescent social support networks.
Healthcare capacity strengthening in conflict settings through virtual emergency medical training and outreach: Ukraine and Sudan case studies
Authors: D’Andrea Shawn M. , Fadul Nada , Dery MarkAlain , Brim William L. , Israel Andrea M. , Struminger Bruce Baird
Published: October 2024

The use of digital learning in healthcare is expanding in a range of contexts including for settings of armed conflict. Humanitarian emergencies and war often lead to a surge of traumatic injuries, emotional distress, and disruption to health systems risking neglect and exacerbations of chronic illness, and acute infectious disease outbreaks, often requiring an international response. On the ground humanitarian response is often essential though logistical and security challenges can delay these responses, and the reliance on an international workforce unfamiliar with local cultures can create challenges in response efforts. In crises where local healthcare workers have limited training, or experience in emergency care, digital health care education can augment in-person response and training efforts. In recent years digital emergency care education programs have been deployed to both Ukraine and Sudan. A review of each of these programs demonstrates successes in and potential utility of remote healthcare capacity strengthening through digital education in settings of war. These programs provide important lessons in strengths of and challenges in developing and delivering just in time learning programs to settings of active armed conflict suggesting similar potential utility in a variety of humanitarian emergency contexts.
Redefining space pharmacology: bridging knowledge gaps in drug efficacy and safety for deep space missions
Authors: Barchetti Karen , Derobertmasure Audrey , Boutouyrie Pierre , Sestili Piero
Published: October 2024

The space environment is incredibly hostile, and humans are vulnerable in such conditions. Astronauts encounter various stress factors during a space journey, including radiation, microgravity, forceful acceleration during launch, altered magnetic fields, and confinement. These stressors significantly impact the human body homeostasis, leading to physio-pathological adaptations, loss of bone density, muscle atrophy, cardiovascular deconditioning, alterations in liver function, vestibular adaptations, and immune system dysregulation. These alterations can potentially influence drug pharmacokinetics and pharmacodynamics, affecting the efficacy and safety of medications administered to astronauts. Due to the limited number of studies on pharmaceuticals conducted in microgravity conditions, it’s challenging to assess the effectiveness and stability of these medications during spaceflight. The objective of the present work is to compare the state-of-the-art knowledge on PK/PD changes and factors likely to affect them during spaceflight, with the subjective perception of the problem by a collection of separate interviews conducted with seven experts in the field. The interviewees were chosen as “experts,” i.e., representatives in a specific discipline, who possess knowledge and experience in space pharmacology, physiology, or biology. Thus, our panel included astronauts, space surgeons, and scientists aiming to bridge the lack of experimental data in the literature. Each interview explores assorted aspects of space physiology and pharmacology, including drug use and storage onboard the ISS; notable consideration has arisen regarding the current research gaps and future space expeditions. All the interviews were held remotely using online conferencing software. None of the interviewees could provide a comprehensive overview regarding potential changes in drugs PK/PD in microgravity conditions. Further, any medication brought on board (whether as part of an astronaut’s medical kit or stored in the ISS pharmacy) is destroyed, thereby suppressing the possibility of analyzing any degradation products resulting from long-term exposure to microgravity and radiation. According to these results, the use of drugs without understanding how they are genuinely absorbed, distributed, metabolized, and excreted in microgravity conditions is concerning, posing risks for drug effectiveness. Conducting genotyping and phenotyping on astronauts would be beneficial for developing personalized pharmacological countermeasures for each astronaut and anticipating expected drug metabolism changes during space missions.
Surgical Hyperspectral imaging and Indocyanine green Near-infrared Examination (SHINE) for brain arteriovenous malformation resection: a case report on how to visualize perfusion
Authors: Wach Johannes , Weber Ferdinand , Vychopen Martin , Arlt Felix , Pfahl Annekatrin , Köhler Hannes , Melzer Andreas , Güresir Erdem
Published: October 2024

Background and importance

Arteriovenous malformations (AVMs) are complex vascular anomalies that pose significant risks, including intracranial hemorrhage and neurological deficits. Surgical resection is the preferred treatment, requiring precise intraoperative imaging to ensure complete removal while preserving critical structures. This case report presents the first combined use of hyperspectral imaging (HSI) and indocyanine green video angiography (ICG VA) to visualize perfusion during brain AVM surgery, highlighting the potential benefits of these advanced imaging techniques.

Case description

A 66-year-old male presented with chronic headaches but no neurological deficits. MRI revealed a superficial AVM in the left frontal lobe within the superior frontal sulcus, measuring approximately 2.4 cm. The AVM was fed by feeders from the pericallosal artery, callosomarginal artery, and middle cerebral artery (MCA) branches, with drainage through a dilated cortical vein into the superior sagittal sinus. Preoperative embolization of two MCA feeding branches was performed, followed by microsurgical resection with ICG VA and HSI.

Conclusions

This case report demonstrates the successful application of HSI and ICG VA in brain AVM surgery. The combined use of these technologies provided comprehensive intraoperative assessment, enhancing surgical precision and safety. The integration of HSI offers non-invasive, contrast-agent-free imaging, potentially improving outcomes by enabling detailed perfusion mapping. Future studies should explore the broader applications of these imaging modalities in neurovascular practice.
In situ assessment of neuroinflammatory cytokines in different stages of ovine natural prion disease
Authors: Guijarro Isabel M. , Garcés Moisés , Badiola Juan J. , Monzón Marta
Published: October 2024

Introduction

According to the neuroinflammatory hypothesis, a cytokine-mediated host innate immune response may be involved in the mechanisms that contribute to the process of neurodegeneration. Specifically, regarding prion diseases, some experimental murine models have evidenced an altered profile of inflammatory intermediaries. However, the local inflammatory response has rarely been assessed, and never in tissues from different natural models throughout the progression of neurodegeneration.

Methods

The aim of this study was to use immunohistochemistry (IHC) to in situ assess the temporal protein expression of several cytokines in the cerebellum of sheep suffering from various clinical stages of scrapie.

Results and discussion

Clear changes in the expression of most of the assessed markers were observed in the affected sheep compared to the healthy control sheep, and from different stages. In summary, this preliminary IHC study focusing in the Purkinje cell layer changes demonstrate that all cytokines or respective receptors studied (IL-1, IL-1R, IL-2R, IL-6, IL-10R, and TNFαR) except for IFNγR are disease-associated signaling proteins showing an increase or decrease in relation to the progression of clinical disease. In the future, this study will be extended to other inflammatory mediators and brain regions, focusing in particular on the release of these inflammatory mediators by astroglial and microglial populations.
Cloning, bioinformatics analysis and expression of the cysteine dioxygenase type 1 (CDO1) gene in domestic yak
Authors: Fu Yuxin , Yan Jiuru , Lan Lan , Zhang Huizhu , Wang Peng , Wang Yaying , Xiong Xianrong , Li Jian , He Honghong
Published: October 2024

Introduction

The CDO1 gene is an important gene in the taurine synthesis pathway and has been observed to have high expression in ovaries of female mammals. This study aims to explore the conservation of CDO1 gene in domestic yaks, as well as to examine the fundamental characteristics of CDO1 gene and its expression in female yaks.

Methods

Ovarian samples were collected from yaks in the follicular phase, luteal phase and gestation period in this experiment, and their total RNA and protein were extracted. Then Polymerase Chain Reaction (PCR) and bioinformatics online software were used to clone and analyze the CDO1 gene. The relative expression of CDO1 in yak ovaries was detected by Quantitative Real-time PCR (RT-qPCR) and Western blotting. The distribution and localization of CDO1 protein in ovary were detected by immunohistochemistry.

Results

We have successfully cloned the coding region of CDO1 gene in yak. The results showed that the CDS region of CDO1 gene was 603 bp, encoding 200 amino acids, and was a relatively stable hydrophilic protein. CDO1 is relatively conservative in species evolution. The protein encoded by CDO1 gene does not have a signaling peptide or a transmembrane structure. It is a protein that is not involved in transmembrane transport and is mainly located in the cytoplasm. The secondary structure of the protein is dominated by the random coil. CDO1 is estimated to interact with 10 proteins. The results of RT-qPCR and Western blotting showed that the CDO1 gene exhibited the highest expression in the ovary during the luteal phase and the lowest expression in the ovary during the follicular phase (P < 0.01). The results of immunohistochemistry showed that CDO1 was mainly expressed in granular cells, theca cells and lutein cells of ovarian tissue.

Conclusion

These results suggest that the CDO1 gene has undergone minimal evolutionary changes during the course of animal evolution. The results provide a reference for further investigation of the function of CDO1 gene in reproduction and production in yaks.
An Online Data-Driven Method for Accurate Detection of Thermal Updrafts Using SINDy
Authors: Lu Yufeng , Liu Chenglou , Hong Haichao , Huang Yunwei , Ji Tingwei , Xie Fangfang
Published: October 2024

Utilizing thermal updrafts shows potential for enabling long-endurance cruising of fixed-wing unmanned aerial vehicles without energy consumption. This article presents a novel online method based on sparse identification of nonlinear dynamics (SINDy) approach to achievement identification of thermal sources in the atmosphere. Initially, the algorithm is incorporated into the upper-level planning system, interacting with the lower-level controller. Then, experiments are conducted through software-in-the-loop simulations (SITL) to validate the implementation of the proposed algorithm. It is found that direct observation of thermal sources through measurements using SINDy is unfeasible during straight and circular flight modes. Nevertheless, simulation analysis of the proposed approach indicates that under unobservable conditions, a portion of the parameters can still be identified. By comparing results obtained using the particle filter algorithm, this method is shown to accurately estimate the parameters with negligible errors under observability conditions. The novelty of this approach lies in its significant improvement of the localization accuracy of the thermal source, without the need for parameter adjustments in the algorithm. Finally, the proposed methods are integrated into commonly used hardware platforms, and their online feasibility is verified through hardware-in-the-loop simulations.
Association of Ovocalyxin-32 Gene Variants with Egg Quality Traits in Indigenous Chicken Breeds
Authors: Yacoub Haitham A. , Fathi Moataz M. , Al-Homidan Ibrahim H. , Badawy Moataz I. , Abdelfattah Mohamed H. , Elzarei Mohamed F. , Abou-Emera Osama K. , Rayan Gamal N.
Published: October 2024

This study sought to evaluate the genetic variations of the ovocalyxin-32 gene and its association with egg quality traits in indigenous chicken populations, focusing on exons 1 and 6. Genotype frequencies of SNPs (G/T and A/G) within these exons were assessed for their conformity to the Hardy–Weinberg equilibrium (HWE) across several strains. While most strains exhibited close adherence to HWE expectations, some like light-brown and gray strains indicated substantial discrepancies, particularly for the TT genotype, which points towards the possible effects of genetic drift as well as selection pressures. This study also analyzed the influence of such SNPs on egg quality parameters. A thinner eggshell, reduced shell weight, and decreased breaking strength were associated with the G/T SNP in exon 1, suggesting a likely negative effect on egg quality in T allele carriers. Conversely, the AG genotype displayed better performance in shell thickness, weight and egg weight in the A/G SNP in exon 1, whilst yolk height was best improved by the AA genotype compared to breaking strength. For instance, in exon 6, the A/G SNP enhanced the shell and yolk quality among AG genotypes, while the CC genotype resulted in better eggshell characteristics with enlarged yolks because the C/T SNP was linked. Nonetheless, there were no significant deviations from the HWE despite these associations, which suggested that most breeds had a stable genetic background. Further, considering SNPs’ additive and dominant effects in this research, it was indicated that additive effects account for phenotypic expressions given by the G/T SNP located at exon 1. In contrast, significant additive and dominant effects were observed under the A/G SNP situated at the exon. Generally, it therefore could be concluded from this study that specific SNPs within the ovocalyxin-32 gene may act as good markers for marker-assisted selection (MAS) that can improve desired characteristics—such as those of egg quality—in indigenous chicken breeds. This study demonstrated that both additive and dominance effects must be taken into account when performing genetic analyses, thereby emphasizing the complexity of phenotypic variation caused by genetic mechanisms in native chicken races.
Computed Tomography Anatomy of the Juvenile Cory’s Shearwater (Calonectris borealis) Normal Nasal Cavity
Authors: Morales-Espino Alejandro , Fumero-Hernández Marcos , Suárez-Cabrera Francisco , Encinoso Mario , Conde-Felipe Magnolia María , Jaber Jose Raduan
Published: October 2024

We conducted a detailed examination of the anterior cranial region of Cory’s Shearwater (Calonectris borealis), employing cutting-edge imaging techniques and computed tomography (CT). The fusion of CT images with anatomical cross-sectional data played a pivotal role in providing a thorough depiction of the components constituting the anterior cranial region of this species. The explication of these structures holds significant potential as an essential procedure for the prognosis and management of diverse pathologies impacting the nasal cavity of Cory’s Shearwater.
Beneficial Effects Induced by a Proprietary Blend of a New Bromelain-Based Polyenzymatic Complex Plus N-Acetylcysteine in Urinary Tract Infections: Results from In Vitro and Ex Vivo Studies
Authors: Recinella Lucia , Pinti Morena , Libero Maria Loreta , Di Lodovico Silvia , Veschi Serena , Piro Anna , Generali Daniele , Acquaviva Alessandra , Nilofar Nilofar , Orlando Giustino , Chiavaroli Annalisa , Ferrante Claudio , Menghini Luigi , Di Simone Simonetta Cristina , Brunetti Luigi , Di Giulio Mara , Leone Sheila
Published: October 2024

Background/Objectives: Urinary tract infections (UTIs) are infections that involve the urethra, bladder, and, in much more severe cases, even kidneys. These infections represent one of the most common diseases worldwide. Various pathogens are responsible for this condition, the most common being Escherichia coli (E. coli). Bromelain is a proteolytic complex obtained from the stem and stalk of Ananas comosus (L.) Merr. showing several beneficial activities. In addition to bromelain, N-acetylcysteine (NAC) has also been used. Methods: The purpose of this experiment was to evaluate the antibacterial, anti-motility, and anti-biofilm effects of a new polyenzymatic complex (DIF17BRO®) in combination with NAC (the Formulation) on various strains of E. coli isolated from patients with UTIs. Subsequently, the anti-inflammatory and antioxidant effects of the Formulation were studied in an ex vivo model of cystitis, using bladder samples from mice exposed to E. coli lipopolysaccharide (LPS). Results: Our results showed that the Formulation significantly affects the capability of bacteria to form biofilm and reduces the bacteria amount in the mature biofilm. Moreover, it combines the interesting properties of NAC and a polyenzyme plant complex based on bromelain in a right dose to affect the E. coli adhesion capability. Finally, the Formulation exhibited protective effects, as confirmed by the inhibitory activities on multiple inflammatory and oxidative stress-related pathways on bladder specimens exposed to LPS. Conclusions: This blend of active compounds could represent a promising and versatile approach to use to overcome the limitations associated with conventional therapies.
Highly Water-Dispersed Natural Fullerenes Coated with Pluronic Polymers as Novel Nanoantioxidants for Enhanced Antioxidant Activity
Authors: Oh Hyeryeon , Lee Jin Sil , Son Panmo , Sim Jooyoung , Park Min Hee , Bang Young Eun , Sung Daekyung , Lim Jong-Min , Choi Won Il
Published: October 2024

Fullerene is a cosmic material with a buckyball-like structure comprising 60 carbon atoms. It has attracted significant interest because of its outstanding antioxidant, antiviral, and antibacterial properties. Natural fullerene (NC60) in shungite meets the demand of biomedical fields to scavenge reactive oxygen species in many diseases. However, its hydrophobicity and poor solubility in water hinder its use as an antioxidant. In this study, highly water-dispersed and stable Pluronic-coated natural fullerene nanoaggregates (NC60/Plu) were prepared from various Pluronic polymers. The water dispersity and stability of NC60 were compared and optimized based on the characteristics of Pluronic polymers including F68, F127, L35, P123, and L81. In particular, NC60 coated with Pluronic F127 at a weight ratio of 1 to 5 showed excellent antioxidant effects both in situ and in vitro. This suggests that the high solubilization of NC60 in Pluronic polymers increases its chance of interacting with reactive oxygen radicals and improves radical scavenging activity. Thus, the optimized NC60/PF127 may be a novel biocompatible antioxidant for treating various diseases associated with oxidative stress.
On the Therapeutic Potential of Heme Oxygenase-1 and Its Metabolites
Authors: Stec David E.
Published: October 2024

Over the past 55 years, the heme oxygenase (HO) system has emerged as a pivotal player in a myriad of cellular, tissue, and integrative physiological processes [...]
Comparative Bioaccesibility Study of Cereal-Based Nutraceutical Ingredients Using INFOGEST Static, Semi-Dynamic and Dynamic In Vitro Gastrointestinal Digestion
Authors: Jiménez-Pulido Iván Jesús , Martín-Diana Ana Belén , Luis Daniel de , Rico Daniel
Published: October 2024

Efficient development of effective functional foods and nutraceuticals requires adequate estimation methods of the bioaccessibility of their bioactive compounds. Specially grain-based nutraceuticals and functional ingredients are often enriched in bound/low bioavailable bioactive phytochemicals. The objective of this work was to evaluate the differences in applying static or dynamic digestion models for the estimation of bioaccessibility of antioxidants present in cereal grain-based/fiber-rich ingredients produced using enzymatic hydrolysis and sprouting processes. Main liberated phenolic compounds, antioxidant activity (ABTS•+ and ORAC) and ferric reducing capacity were evaluated in the samples following three digestion protocols with differences based on their dynamism: static, semi-dynamic and dynamic. The samples digested with the dynamic method showed higher antioxidant and reducing capacities than those digested with the static and semi-dynamic protocols. The results obtained from the digests with the dynamic model showed a total phenol content (TPs) ranging from 1068.22 to 1456.65 μmol GAE 100 g−1 and antioxidant capacity values from 7944.62 to 15,641.90 μmol TE 100 g−1 (ORAC) and from 8454.08 to 11,002.64 μmol TE 100 g−1 (ABTS•+), with a reducing power ranging from 2103.32 to 2679.78 mmol Fe reduced 100 g−1 (FRAP). The dynamic character of the protocols used for developing bioactive cereal-based foods significantly affects the estimation of their bioaccessibility, probably giving a better approach to their potential bioavailability in in vivo systems.
The Ubiquitous and Multifaceted Coenzyme Q
Authors: Tiano Luca , Navas Plácido
Published: October 2024

Coenzyme Q10 (CoQ10) is composed of a benzoquinone ring and an isoprenoid side chain attached to carbon 3 of the ring [...]
Antioxidants: A Hot Controversy Defused by Cool Semantics
Authors: Abdin Ahmad Yaman , Nasim Muhammad Jawad , Jacob Claus
Published: October 2024

Recent years have witnessed a rather controversial debate on what antioxidants are and how beneficial they may be in the context of human health. Despite a considerable increase in scientific evidence, the matter remains highly divisive as different pieces of new data seem to support both the pro- and the anti-antioxidant perspective. Here, we argue that the matter at the heart of this debate is not necessarily empirical but of semantics. Thus, the controversy cannot be resolved with the traditional tools of natural sciences and by the mere accumulation of new data. In fact, the term “antioxidants” has been part of the scientific language game for a few decades and is nowadays used differently in the context of different scientific disciplines active at different levels of scientific complexity. It, therefore, represents not a single expression but an entire family of words with distinctively different connotations and associations. The transcendent use of this expression from a basic to a more complex discipline, such as going from chemistry to physiology, is problematic as it assigns the term with connotations that are not corroborated empirically. This may lead to false claims and aspirations not warranted by empirical data. Initially, health claims may not even be indented, yet, on occasion, they are welcome for reasons other than scientific ones. To resolve this debate, one may need to refrain from using the term “antioxidants” in disciplines and contexts where its meaning is unclear, limit its use to disciplines where it is essential and beneficial, and, in any case, become more specific in such contexts where its use is warranted, for instance, in the case of “dietary antioxidants”.
Application of Differential Scanning Calorimetry and Thermogravimetry for Thermal Analysis of Dark Chocolates
Authors: Ostrowska-Ligęza Ewa , Wirkowska-Wojdyła Magdalena , Brzezińska Rita , Piasecka Iga , Synowiec Alicja , Gondek Ewa , Górska Agata
Published: October 2024

Dark chocolate is a confectionery product traditionally made from cocoa beans, sugar, and vanilla essence. The aim of the study was to investigate the thermal properties of dark chocolates and fats extracted from these chocolates using thermal methods of food analysis, such as differential scanning calorimetry (DSC) and thermogravimetry (TG). The profile of fatty acids in the fat extracted from the chocolates was also determined. The presence of three fatty acids (palmitic P, stearic S, and oleic O) constituting triacylglycerols—SOS, POP, POS, POO, and SOO—was observed in all the samples. The presence of linoleic acid (L) was also found, which forms triacylglycerols such as PLP and PLS. The researched chocolates were characterized by a diverse composition of fatty acids. In all the obtained DSC melting curves of fats, the presence of endothermic peaks was observed. The peaks, appearing at negative temperatures, may be caused by the transition of low-melting triacylglycerols. The differences between the melting curves for the obtained dark chocolate fats may have resulted from the presence of less stable polymorphic forms of cocoa butter. Based on the shape of the TG and DTG curves, it could be possible to indicate the adulteration of chocolates.
Impact of Nanoparticle Addition and Ozone Pre-Treatment on Mesophilic Methanogenesis in Temperature-Phased Anaerobic Digestion
Authors: Díaz Domínguez Encarnación , Ibañez López María Eugenia , Mąkinia Jacek , Fernández-Morales Francisco Jesús , García Morales José Luis
Published: October 2024

Biodegradable organic waste offers significant opportunities for resource recovery within the frame of the circular economy. In this work, the effects of carbon-encapsulated iron nanoparticles and ozone pre-treatments in the mesophilic methanogenic stage of a temperature-phased an-aerobic digestion have been studied using biochemical methanogenic potential (BMP) tests and modeling simulation. To do that, digestates from a pre-treated thermophilic acidogenic reactor that co-digested sludge and wine vinasse were used. The addition of nanoparticles favored the removal of particulate matter, which increased by 9% and 6% in terms of total solids and volatile solids, respectively. When combined with ozone pre-treatment, these increases were 27% and 24%, respectively, demonstrating enhanced AD efficiency. The dose of iron nanoparticles encapsulated in carbon did not result in a statistically significant increase in methane production when sludge and vinasse were used as feedstock. The combination of nanoparticles with the ozone pre-treatment significantly improved the methanogenic phase of the second stage, increasing the methane production yield by 22% and reducing the lag phase from 10 days to 3 days, according to the modified Gompertz model.
Exploring Whole-Body Vibration Transmission Through the Human Body in Different Postures on a Large Vibration Platform
Authors: Gisbert-Orozco Jose F. , Fernández-Valdés Bruno , Arcos Villamarin Robert , González-Otazo Jacob , Ramírez-López Carlos , Moras Feliu Gerard
Published: October 2024

The positive effects of whole-body vibration exercise in rehabilitation, sport, fitness and preventive medicine have led to a proliferation of vibrating platforms. However, discrepancies have been claimed between the manufacturers’ vibration parameters and the vibration applied by the platforms. In addition, the dimensions, materials and motors used in their manufacture mean that each platform behaves differently. These factors can influence their transmission to the human body and, consequently, their effects. Thus, measured vibration parameters were recommended to report the vibration parameters as accurately as possible. Therefore, the present study aimed to determine the feasibility of a large vibration platform. Measurements of vibration parameters and their transmission were added. These parameters were measured using six accelerometers (platform, ankle, knee, hip, third lumbar vertebra, and head) throughout five postures (toe-standing, erect, high squat, deep squat, and lunge) and three vibration frequencies (20 Hz, 25 Hz, and 30 Hz). On the platform, peak accelerations of 1 ± 0.2 g, displacements of 1 ± 0.1 mm at 20 Hz and 25 Hz and 0.6 mm at 30 Hz, and a frequency from the setting of +0.5 Hz were obtained. In the human body, peak accelerations can exceed 2 g, and these transmissibility amplifications were found at the ankles and knees. However, at the hip, accelerations plummet and transmissibility attenuation occurs all the way to the head. The signal purity was highly satisfactory, although at the hip and third lumbar vertebra when adopting the toe-standing and lunge, some less satisfactory results were found—especially at 20 Hz and 30 Hz. Present data indicate that the long vibration platform can be used for exercise and health in a safe way, although its specific behaviours have to be taken into account in order to optimise its applicability.
Carbonyl Compounds Observed at a Suburban Site during an Unusual Wintertime Ozone Pollution Event in Guangzhou
Authors: Ge Aoqi , Wu Zhenfeng , Xiao Shaoxuan , Huang Xiaoqing , Song Wei , Zhang Zhou , Zhang Yanli , Wang Xinming
Published: October 2024

Carbonyl compounds are important oxygenated volatile organic compounds (VOCs) that play significant roles in the formation of ozone (O3) and atmospheric chemistry. This study presents comprehensive field observations of carbonyl compounds during an unusual wintertime ozone pollution event at a suburban site in Guangzhou, South China, from 19 to 28 December 2020. The aim was to investigate the characteristics and sources of carbonyls, as well as their contributions to O3 formation. Formaldehyde, acetone, and acetaldehyde were the most abundant carbonyls detected, with average concentrations of 7.11 ± 1.80, 5.21 ± 1.13, and 3.00 ± 0.94 ppbv, respectively, on pollution days, significantly higher than those of 2.57 ± 1.12, 2.73 ± 0.88, and 1.10 ± 0.48 ppbv, respectively, on nonpollution days. The Frame for 0-D Atmospheric Modeling (F0AM) box model simulations revealed that local production accounted for 62–88% of observed O3 concentrations during the pollution days. The calculated ozone formation potentials (OFPs) for various precursors (carbonyls and VOCs) indicated that carbonyl compounds contributed 32.87% of the total OFPs on nonpollution days and 36.71% on pollution days, respectively. Formaldehyde, acetaldehyde, and methylglyoxal were identified as the most reactive carbonyls, and formaldehyde ranked top in OFPs, and it alone contributed 15.92% of total OFPs on nonpollution days and 18.10% of total OFPs on pollution days, respectively. The calculation of relative incremental reactivity (RIR) indicates that ozone sensitivity was a VOC-limited regime, and carbonyls showed greater RIRs than other groups of VOCs. The model simulation showed that secondary formation has a significant impact on formaldehyde production, which is primarily controlled by alkenes and biogenic VOCs. The characteristic ratios and backward trajectory analysis also indicated the indispensable impacts of local primary sources (like industrial emissions and vehicle emissions) and regional sources (like biomass burning) through transportation. This study highlights the important roles of carbonyls, particularly formaldehyde, in forming ozone pollution in megacities like the Pearl River Delta region.
Patterns and Drivers of Greenhouse Gas Emissions in a Tropical Rubber Plantation from Hainan, Danzhou
Authors: Yang Siqi , Xian Yuanhong , Tang Wei , Fang Mengyang , Song Bo , Hu Qing , Wu Zhixiang
Published: October 2024

The intensification of global climate change has made the study of greenhouse gas (GHG) emissions increasingly important. To gain a deeper understanding of the emission characteristics and driving factors of nitrous oxide (N2O), carbon dioxide (CO2), and methane (CH4) from rubber plantation soils, this study conducted a 16-month continuous observation in a rubber plantation in Danzhou, Hainan, employing the static chamber method for the monthly sampling and measurement of GHG emissions while analyzing the soil’s physical and chemical properties. The results indicated that the N2O flux exhibited no significant diurnal variation between the dry and rainy seasons, with an average emission rate of 0.03 ± 0.002 mg·m−2·h−1. A clear seasonal trend was observed, with higher emissions in summer than in winter, resulting in an annual flux of 3 kg·hm−2·a−1 (equivalent to 1.9 kg N·hm−2·a−1). N2O emissions were significantly correlated with soil temperature and moisture, explaining 46% and 40% of the variations, respectively, while soil ammonium nitrogen content also significantly influenced N2O and CO2 emissions. The rubber plantation soil acted as a source of N2O and CO2 emissions and a sink for CH2, with lower emissions of N2O and CO2 during the daytime compared to nighttime, and higher CH4 uptake during the daytime. In the dry season, there was a significant positive correlation between N2O and CO2 emissions (R2 = 0.74, p < 0.001). This study reveals the diurnal and seasonal patterns of GHG emissions from rubber plantation soils in Hainan and their interrelationships, providing a scientific basis for the low-carbon management of rubber plantations and GHG mitigation strategies, thereby contributing to attempts to reduce the impact of rubber cultivation on climate change.
Methods, Progress and Challenges in Global Monitoring of Carbon Emissions from Biomass Combustion
Authors: Qu Ge , Shi Yusheng , Yang Yongliang , Wu Wen , Zhou Zhitao
Published: October 2024

Global biomass burning represents a significant source of carbon emissions, exerting a substantial influence on the global carbon cycle and climate change. As global carbon emissions become increasingly concerning, accurately quantifying the carbon emissions from biomass burning has emerged as a pivotal and challenging area of scientific research. This paper presents a comprehensive review of the primary monitoring techniques for carbon emissions from biomass burning, encompassing both bottom-up and top-down approaches. It examines the current status and limitations of these techniques in practice. The bottom-up method primarily employs terrestrial ecosystem models, emission inventory methods, and fire radiation power (FRP) techniques, which rely on the integration of fire activity data and emission factors to estimate carbon emissions. The top-down method employs atmospheric observation data and atmospheric chemical transport models to invert carbon emission fluxes. Both methods continue to face significant challenges, such as limited satellite resolution affecting data accuracy, uncertainties in emission factors in regions lacking ground validation, and difficulties in model optimization due to the complexity of atmospheric processes. In light of these considerations, this paper explores the prospective evolution of carbon emission monitoring technology for biomass burning, with a particular emphasis on the significance of high-precision estimation methodologies, technological advancements in satellite remote sensing, and the optimization of global emission inventories. This study aims to provide a forward-looking perspective on the evolution of carbon emission monitoring from biomass burning, offering a valuable reference point for related scientific research and policy formulation.
Symmetry Reductions of the (1 + 1)-Dimensional Broer–Kaup System Using the Generalized Double Reduction Method
Authors: Kakuli Molahlehi Charles , Sinkala Winter , Masemola Phetogo
Published: October 2024

The generalized theory of the double reduction of systems of partial differential equations (PDEs) based on the association of conservation laws with Lie–Bäcklund symmetries is one of the most effective algorithms for performing symmetry reductions of PDEs. In this article, we apply the theory to a (1 + 1)-dimensional Broer–Kaup (BK) system, which is a pair of nonlinear PDEs that arise in the modeling of the propagation of long waves in shallow water. We find symmetries and construct six local conservation laws of the BK system arising from low-order multipliers. We establish associations between the Lie point symmetries and conservation laws and exploit the association to perform double reductions of the system, reducing it to first-order ordinary differential equations or algebraic equations. Our paper contributes to the broader understanding and application of the generalized double reduction method in the analysis of nonlinear PDEs.
Safety Aspects of Sodium-Ion Batteries: Prospective Analysis from First Generation Towards More Advanced Systems
Authors: Bhutia Pempa Tshering , Grugeon Sylvie , El Mejdoubi Asmae , Laruelle Stéphane , Marlair Guy
Published: October 2024

After an introductory reminder of safety concerns pertaining to early rechargeable battery technologies, this review discusses current understandings and challenges of advanced sodium-ion batteries. Sodium-ion technology is now being marketed by industrial promoters who are advocating its workable capacity, as well as its use of readily accessible and cheaper key cell components. Often claimed to be safer than lithium-ion cells, currently only limited scientifically sound safety assessments of sodium-ion cells have been performed. However, the predicted sodium-ion development roadmap reveals that significant variants of sodium-ion batteries have entered or will potentially enter the market soon. With recent experiences of lithium-ion battery failures, sodium-ion battery safety management will constitute a key aspect of successful market penetration. As such, this review discusses the safety issues of sodium-ion batteries, presenting a twofold innovative perspective: (i) in terms of comparison with the parent lithium-ion technology making use of the same working principle and similar flammable non-aqueous solvent basis, and (ii) anticipating the arrival of innovative sub-chemistries at least partially inspired from successive generations of lithium-ion cells. The authors hope that the analysis provided will assist concerned stakeholders in the quest for safe marketing of sodium-ion batteries.
Estimation of Lower Limb Joint Angles Using sEMG Signals and RGB-D Camera
Authors: Du Guoming , Ding Zhen , Guo Hao , Song Meichao , Jiang Feng
Published: October 2024

Estimating human joint angles is a crucial task in motion analysis, gesture recognition, and motion intention prediction. This paper presents a novel model-based approach for generating reliable and accurate human joint angle estimation using a dual-branch network. The proposed network leverages combined features derived from encoded sEMG signals and RGB-D image data. To ensure the accuracy and reliability of the estimation algorithm, the proposed network employs a convolutional autoencoder to generate a high-level compression of sEMG features aimed at motion prediction. Considering the variability in the distribution of sEMG signals, the proposed network introduces a vision-based joint regression network to maintain the stability of combined features. Taking into account latency, occlusion, and shading issues with vision data acquisition, the feature fusion network utilizes high-frequency sEMG features as weights for specific features extracted from image data. The proposed method achieves effective human body joint angle estimation for motion analysis and motion intention prediction by mitigating the effects of non-stationary sEMG signals.