Preoperative Localization in Colonic Surgery (PLoCoS Study): a multicentric experience on behalf of the Italian Society of Colorectal Surgery (SICCR)
Authors: Manigrasso Michele , Milone Marco , Musella Mario , Venetucci Pietro , Maione Francesco , Elmore Ugo , Gallo Gaetano , Perinotti Roberto , De Palma Giovanni Domenico ,   PLoCoS Study Group, Sarnelli Giovanni , Gennarelli Nicola , Vertaldi Sara , Sammarco Giuseppe , Vescio Giuseppina , Tiesi Vincenzo , Pata Francesco , Altomare Donato Francesco , Picciariello Arcangelo , Papagni Vincenzo , Vincenti Leonardo , Mistrangelo Massimiliano , Forcignanò Edoardo , Salzano Antonio , Bondurri Andrea , Maffioli Anna , Colombo Francesco , Lauretta Andrea , Sica Giuseppe , Campanelli Michela , Stella Marco , Boati Paolo , Ferrara Francesco , Selvaggi Francesco , Pellino Gianluca , Romano Francesco Maria , Selvaggi Lucio , Panis Yves , Frontali Alice , Spiezio Giovanni , Spinelli Antonino , Di Candido Francesca , Maroli Annalisa , Coco Claudio , Rizzo Gianluca , Moggia Elisabetta , Luglio Gaetano , Pagano Gianluca , Tropeano Francesca Paola , Peltrini Roberto , Marchesi Federico , Petracca Gabriele Luciano , Dalmonte Giorgio , Valente Marina , Giuliani Antonio , Impellizzeri Harmony , Marrano Enrico , Moretto Gianluigi , Folliero Cristina , Langone Antonio , Caristo Giuseppe , Graziano Giorgio Maria Paolo , Amico Angelo , Di Cataldo Antonio , Maida Pietro , Marra Ester , Abete Roberta , Castaldi Antonio , Palumbo Alessio , Foroni Fabrizio , Antropoli Carmine , De Nardi Paola , Quattromani Roberto , Rosati Riccardo 
Published: October 2021

The aim of this prospective multicentric study was to compare the accurate colonic lesion localization ratio between CT and colonoscopy in comparison with surgery. All consecutive patients from 1st January to 31st December 2019 with a histologically confirmed diagnosis of dysplastic adenoma or adenocarcinoma with planned elective, curative colonic resection who underwent both colonoscopy and CT scans were included. Each patient underwent conventional colonoscopy and CT to stage the tumour, and the localization results of each procedure were registered. CT and colonoscopic localization were compared with surgical localization, adopted as the reference. Our analysis included 745 patients from 23 centres. After comparing the accuracy of colonoscopy and CT (for visible lesions) in localizing colonic lesions, no significant differences were found between the two preoperative tools (510/661 vs 499/661 correctly localized lesions, p = 0.518). Furthermore, after analysing only the patients who underwent complete colonoscopy and had a visible lesion on CT, no significant difference was observed between conventional colonoscopy and CT (331/427 vs 340/427, p = 0.505). Considering the intraoperative localization results as a reference, a comparison between colonoscopy and CT showed that colonoscopy significantly failed to correctly locate the lesions localized in the descending colon (17/32 vs 26/32, p = 0.031). We did not identify an advantage in using CT to localize colonic tumours. In this setting, colonoscopy should be considered the reference to properly localize lesions; however, to better identify lesions in the descending colon, CT could be considered a valuable tool to improve the accuracy of lesion localization.