bluuebunny/crossref_metadata_2025 huggingface dataset:
Estrés oxidativo e ingesta de Passiflora edulis en voleibolistas hombres
Authors: García-Cardona Diana María , Landázuri Patricia , Restrepo Cortés Beatriz , Sánchez-Muñoz Oscar Eduardo
Published: November 2021

Introducción: El estrés oxidativo, puede disminuir el rendimiento deportivo, generando una posible sobrecarga muscular. Una adecuada alimentación contribuye a disminuir los productos derivados del estrés oxidativo; un alimento antiestrés oxidativo es el fruto de la Passiflora edulis, ya que se ha comprobado in-vitro su alto contenido polifenólico. Objetivo: Determinar el efecto del consumo de Passiflora edulis sobre marcadores de estrés oxidativo en voleibolistas durante un microciclo de choque. Metodología: Voluntariamente participaron 14 voleibolistas; aleatoriamente fueron divididos en grupo experimental (GE) y grupo placebo (GP), ambos grupos entraron al microciclo de choque. Durante los siete días del microciclo, GE consumió 2 ml/día de zumo de Passiflora edulis (1mg/ml) y GP recibió 2 ml de placebo. Se tomaron 4 muestras sanguíneas durante los días 1(D1), 4(D4), 7(D7) y 14(D14). Se determinó catalasa (CAT), superóxido dismutasa (SOD) y las sustancias reactivas al ácido tiobarbitúrico (TBARS). Resultados: Durante el microciclo, SOD incremento en ambos grupos, en D4 con respecto al D1, y disminuyó del D14 con respecto al D7 ambos significativamente. La CAT no presentó diferencias estadísticas entre los días evaluados. Las diferencias estadísticas con respecto a TBARS únicamente se presentaron en GE y fueron en el incremento del D4 con respecto al D1, y en el descenso del D14 con respecto al D7. No hubo diferencias significativas al comparar las mediciones realizadas entre el GE y el GP. Conclusión: No se encontró efecto significativo del consumo de P. edulis sobre los marcadores de estrés oxidativo evaluados, es necesario evaluar diferentes concentraciones del zumo.
Novel, Rapid, Isocratic RP-HPLC Method for Simultaneous Estimation of Piperine and Embelin in Herbal Formulation
Authors: Jain Vandana , Sonone Revati , Tandel Leena
Published: November 2021

The objective of this paper was to develop and validate a novel, simple, rapid, precise and accurate, reverse-phase high-performance
liquid chromatographic (RP-HPLC) method for simultaneous quantitative estimation of piperine and embelin in the herbal formulation
as per the International Conference on Harmonization guidelines (ICH). Chromatographic separation was achieved using a Cosmosil
C-18 (250*4.6mm) SH 5.0 µm column with a mobile phase consisting of methanol and 0.02 M phosphate buffer in ratio 98:2 v/v,
(pH adjusted to 2.3 with ortho-phosphoric acid) at a flow rate of 1 mL/min and column temperature maintained at 28°C and
ultraviolet (UV) detection at 288 nm. The retention time of piperine and embelin was found to be 4.15 and 5.69 min respectively. The
linearity of piperine and embelin was tested in the range of 5-40 ?g/mL. The correlation coefficient for piperine and embelin was
found to be 0.997 and 0.995, respectively. The recovery values (98-102%) indicate a satisfactory accuracy. The method was found to
be precise as the percentage relative standard deviation was found to be <2 %. The proposed novel isocratic RP-HPLC method is rapid
(short run time below 10 min), precise, accurate and sensitive. The method was successfully applied for the simultaneous analysis of
piperine and embelin in herbal formulation.
A Case Report on Osborn Waves of Hypothermia Induced LV Systolic Dysfunction
Authors: Singha Rajnandini , Siangshai Amazing Grace , Lijo Jashlyn
Published: November 2021

Hypothermia, described as a core body temperature of < 95%, is associated with ECG alteration abnormalities. Sinus bradycardia
occurs when the body temperature drops below 90°F, and is correlated with gradual prolongation of the PR interval, QRS complex,
QT interval. It can progress to ventricular and atrial fibrillation at a temperature reaching 89°F, which can lead to left ventricular
dysfunction. Hypothermia is connected to the osborn waves, which at the end of the QRS complex consist of additional deflection.
The inferior and lateral precordial leads are seen by Osborn waves, also known as J waves, Camel hump waves and hypothermic
waves. As the body temperature decreases, it becomes more pronounced and a gradual expansion of the QRS complex raises the
likelihood of ventricular fibrillation causing ventricle dysfunction.
Diabetes and Depression: A Bidirectional Phenomenon
Authors: Modak Somnath , Ghosh Moumita , Chakraborty Manodeep , Chutia Devid , Bhuyan Nihar Ranjan
Published: November 2021

Diabetes mellitus is a strong molecular etiological upstream event that leads to different pathological problems like Cardio-vascular
disease, nephropathy, neuropathy, retinopathy, hearing loss, and immunological disturbances, the most common of which is
depression. Diabetes and depression relationship is thought to be bidirectional, meaning that depression can lead to diabetes and
diabetes can assist the onset of depression. Depression is one of the most overlooked symptoms in diabetes patients, and it is strongly
related to a decline in quality of life. Several pathological links are discussed in this review, including dysregulation of the hypothalamic
pituitary-adrenal (HPA) axis and neurotransmitter systems, particularly the monoaminergic system, the role of oxidative stress,
neuroinflammation, and cell death, impaired neurogenesis and BDNF synthesis, particularly in the hippocampus and prefrontal cortex, brain areas that regulate emotional behaviour, and finally, epigenetic factors.
Emerging Nanoparticles in the Diagnosis of Atherosclerosis
Authors: Kataria Tanushka , Hussain Sadique , Kaur Gurleen , Deb Anuska
Published: November 2021

Throughout the last few decades, cardiovascular research has substantially advanced our awareness of the atherosclerotic process,
the molecular processes underlying the disease remain essentially unexplained. Atherosclerosis results from the imbalanced lipid
metabolism and lipoproteins accumulation that results in the thickening of the artery walls, linked to most cardiovascular events, and
also one of the foremost common causes of morbidity and mortality around the world. Despite the extensive investigation into the
process of development and advancement of atherosclerotic lesions over the years, there is little information is available. The use
and handling of nanotechnology on a molecular scale is a new approach to quantify the functional organization in nanometers. In
medicine, it is capable to improve diagnostics, delivery of pharmaceuticals, treatment, and many areas of research, development,
and clinical application. Medical nanotechnology or nanomedicine has demonstrated a growing trend in the reduction of costs and
improve the efficiency of current medicines, diagnostic reagents, implants, etc. Nanomedicine overcomes certain problems of
conventional drugs like drug toxicity and the required dose of the drug. Promising research has resulted in pre-clinical validation of
nanoscale devices targeting cell and molecular components of atherosclerotic plaque in the past decade. This review paper will cover basic insights into the use of nanomedicine in atherosclerosis
Ayurvedic Remedies of Covid-19
Authors: Devade Omkar , Londhe Rohan , Rathod Namrata , Kupate Jyoti , Meshram Nikhil
Published: November 2021

The Sanskrit term Ayurveda has translated knowledge of life. It is one of the world's oldest healing systems that originated in eastern
culture and it includes numerous medical concepts and it’s a hypothesis for treatment and prevention of disease. In ancient times
near to 3000 years ago in India when there are no synthetic medicines was developed then people used Ayurvedic plants to get cures
for different diseases. Ayurveda is based on a belief that health and wellness depend on a delicate balance of mind, body, and spirit.
Ayurvedic herbs are key components of Ayurveda. COVID-19 is an infectious disease found in December 2019 and it has now become
a pandemic. The COVID-19 infection is produced by virulent severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) virus
although various antiviral drugs are available for controlling the infection but sometimes, they lack in supply for treating the
worldwide population. So, it has become imperative to develop an effective medical strategy for the management of COVID-19 which
has become a major threat to humanity. Herbs exhibit various biological activities so; they can effectively help with managing the
pandemic. This review discussed some herbs which have the potential for the treatment of COVID-19.
Channelopathies an Approach to Elevate Level of Cure- A Review
Authors: Sawarkar Rahul , Bhandarkar Saurabh , Mendhi Sachin , More Sachin
Published: November 2021

Channelopathies is group of diseases which is concerned with changes occur in the structural unit i.e., cell and its subunits (channels).
Particularly disturbances in equilibrium potential in cell membrane carry toward the major cause of disease. Study of channel
physiology with its mechanism is essential methodology to establish the differential factor in between normal phenomenon and
disorder. Specific channels permit movement of selected ions through cellular membranes and are of important importance during
variety of physiological processes, particularly in excitable tissues. In this review channelopathies in diseases like Central nervous
system, Cardiovascular system, Renal system with their mechanism of action of channel disruption and treatment approaches have
been covered.
A Retroprospective Study of an Antimicrobial Stewardship Program on Antimicrobial Utilization at a Tertiary Care Medical Center in Kolkata
Authors: Deb Sujay Ranjan , Maiti Sourav , Roy Arpan Dutta , Paul Prolay , Maiti Dipankar , Adhikary Triyasha
Published: November 2021

The WHO has set Defined Daily Dose which represent the average daily dose of an antibiotic in a standard patient. The DDD mainly
focuses on population-based parameters & assumes that patients as well as hospitals are homogenous entities. DOTs are very useful
in order to classify antibiotic days based on patient-level exposure. DOTs merely mean the number of days that a patient is on an
antibiotic, irrespective of dose. DOTs signifies that the underlying assumptions about antibiotic dosing was appropriate. Additionally,
when patients receive more than one antibiotic, supplementary DOT may be counted. The 300-bed tertiary care medical center serves
adults and paediatrics. An all-time Microbiology Consultant and a Clinical Pharmacology trainee used to go for round daily and used
to collect data for ASP for the period of 3 months that is April to June,2021. In this study we have compared DOT of some important
antibiotics for a specific period of time for both COVID and NON COVID patient. ASP-focused antibiotics were antibiotics routinely
evaluated by the ASP team for appropriateness during therapy and the potential to optimize their appropriate use through policies,
protocols, formulary restrictions, or clinician education. ASP-focused antibiotics included meropenem, linezolid, pip-taz, poly b,
colistin, teicoplanin. In this study we have compared the DDD for 2 specific period of time for better understanding the consumption
of those antibiotics. In conclusion, following the initiation of an ASP, significant decreases in utilization, increases in cost savings
occurred. In our study we have reduced the consumption and DDD of linezolid which is clinically significant. When it comes to DOTs;
We have reduced the DOTs of piptaz and teicoplanin for covid patient And Reduced the DOTs of meropenem and teicoplanin for noncovid patient which is clinically and statistically significant.
A Systemic Review of Clinical Trial of 2 -deoxyglucose in Treating Covid-19
Authors: Sheikh Aafrin , Padole Vaishnavi , More Sachin , Mendhi Sachin
Published: November 2021

After sudden outbreak of covid-19 pandemic, to overcome this chaotic situation many drug therapies have been used which includes
Chloroquine, Hydroxychloroquine (Antimalarial), Lopinavir and Ritonavir (antiviral), Nafamostat (Sirin protease inhibitor), Famotidine
(Antihistamines), Nitazoxanide (Anti-infective), Evermectin (Anti-parasitic), Corticosteroids, Tocilizumab & Sarilumab (Inflammatory
cytokine), Fluvoxamine(Anti-depressants), but due to prominent effect of 2-DG it has been extensively used against SARS-CoV-2. It is
a glucose molecule which was approved for the emergency treatment in covid-19 pandemic against SARS-CoV-2 by inhibiting
glycolysis-The energetic cycle. It shows more highlighting effect with combinational approach. This drug was sanctioned by Drug
Controller General of India (DCGI) and has been developed by Institute of medicine and Allied Sciences (INMAS), a lab of Defence
Research and Development Organization (DRDO), together with Dr Reddy’s Laboratories (DRL), Hyderabad.
A Pervasive Review on New Advancements of Nano Vaccines on Covid-19 Pandemic
Authors: Nath Ranajit , Mandal Ambika , Bhowmik Ratul , Roy Ratna , Biswas Riya , Bhattacharyya Soubhik
Published: November 2021

The infection that causes COVID-19 may be a pathogen referred to as severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and is believed to possess originated from China's Wuhan Province. The rapid spread of coronavirus disease 2019 (COVID-19) has
become a worldwide concern, with the planet Health Organization (WHO) declaring it an epidemic on March, 2020. To enter the cells,
SARS-CoV-2 S requires angiotensin-converting enzyme 2 (ACE2). Many existing vaccines have drawbacks like insufficient system
stimulation, in vivo instability, high toxicity, the need for a chilly chain, and multiple administration. A nanotechnology is an efficient
tool for addressing these issues. A successful vaccine against SARS-CoV-2 infection is predicted to stimulate innate and adaptive
immune responses and protects against severe sorts of coronavirus disease 2019 (COVID-19). Different strategies are introduced
because the go after an efficient and safe vaccination has begun. Currently, the foremost common vaccine types studied in clinical
trials include viral vector-based vaccinations, genetic vaccines, attenuated vaccines, and protein-based vaccines. during this review,
we cover the foremost promising anti-COVID-19 vaccine clinical trials also as various vaccination strategies to shed more light on the
continued clinical trials. it's also discussed how nanotechnology is often wont to better understand the pathology of the present
pandemic, also as how our understanding of SARS-CoV-2 cellular uptake and toxicity can influence future nanotoxicological
considerations and nanomedicine design of safe yet effective nanomaterials.
Formulation and Evaluation of A Nanoparticle Laden in Situ Gel System for Enhancing the Ocular Delivery of Ciprofloxacin
Authors: Datta Sourav , Bhowmik Ratul , Nath Ranajit , Chakraborty Rajarshi , Chakraborty Apala
Published: November 2021

The human eye can be a tricky issue for topical administration of the drugs due to its unique anatomical arrangements of surface
tissue and corneal impermeability. Topical instillation of drugs in the form of eye drops is the major and well-accepted route of
administration for the treatment of varied eye disorders. Conventional ophthalmic drug delivery systems often lead to poor
bioavailability and thus reduced therapeutic response. Several new preparations are developed to enhance the contact time of the
medicament on the surface of the eye. Successful results have been obtained in the form of inserts and collagen shields. However,
these preparations have also some disadvantages, such as poor patient compliance, particularly in the case of elderly patients. These
problems could be solved by using nanoparticles laden in situ gel-forming systems that exhibit phase transition from solution to gel.
These nanoparticle in situ gel systems may be formulated as eye drops suitable for administration through instillation into the eye,
which upon exposure to the eye, stimulated by various ocular physiological factors, converts to the gel phase. The advantage of those
formulations is that unlike inserts and films they do not require complicated equipment for manufacture and that they are scalable
without any difficulty. The objective of the present study was to prepare a pH-dependent nanoparticle-laden in situ gel system for
Ciprofloxacin, to prolong the release of the drug into the ocular compartment. No incompatibility was found between the drug and
the excipients. Nanoparticles were developed using the nanoprecipitation technique. Eudragit RL 100 was used as the polymer. While
the in situ gel solution was formulated using chitosan as polymer. The Ciprofloxacin nanoparticles were measured for particle size
and the average particle size was ranged from 295.3-458.7 nm. Entrapment efficiency ranged from 13.83% to 6.29%. Nanoparticleladen in situ gels had the pH of the formulati
Preparation and Evaluation of a Novel Oral Microemulsion Drug Delivery System for Enhancing the Bioavailability of Diltiazem
Authors: Nath Ranajit , Bhowmik Ratul , Chakraborty Rajarshi , Datta Sourav , Chakraborty Apala
Published: November 2021

Diltiazem, a calcium ion cellular influx inhibitor is known for its limited and variable bioavailability. This study is intended to explore
the benefits of microemulsion formulation as an oral drug delivery system for immediate release to improve the bioavailability and
efficacy of Diltiazem. Methods: Oil in water microemulsion was prepared using the simple water titration method. The optimized
formulation was evaluated for physicochemical parameters like viscosity, pH, conductivity, and accelerated stability studies. In vitro
release, diltiazem microemulsion was investigated.
A Comparative Study to Assess the Rates on the Recovery of Covid-19 Patients with or without Co-morbidities in Tertiary Care Hospital
Authors: K Dr. Jaya Prakash , Nirojini Dr. P.Sharmila , Johny Neeya , S. Niranjana , Wilson Neenu , S. Pavithra , T. Nivashini
Published: November 2021

Coronavirus disease of 2019 (COVID-19) is a highly contagious infectious disease which lead to a global pandemic. This virus attacks
the small blood vessels, endothelial linings and lead to impaired blood flow and vessel malfunctioning's in various organs. This explains
the reason why the high vulnerability patient population is those with comorbidities like hypertension, diabetes, COPD, obesity and
cardiovascular diseases. The objective of the study was to compare the rates of recovery in the comorbid Covid-19 patient population
when compared to those without comorbidities by evaluating their CT Chest - Score, RT- PCR, duration of hospitalization and thereby
assess if the quality of life was compromised. A Prospective Observational Study was conducted for a period of 4 months with over
400 laboratory-confirmed Covid-19 patients. Out of the 400 patients, considering the exclusion and inclusion criteria 191 moderately
ill covid-19 patients with or without comorbidities were included in the study. The severity of the patients was assessed based on the
CT- Chest Score and COVID-19 RT-PCR reports. Various other complications faced by comorbid patients when compared to patients
with nil comorbidities were also investigated. In our study among the underlying comorbidities, the most common were DM (40.11%),
HTN (35.32 %), CAD (7.78 %), COPD (6.58 %), CKD (5.38 %) and then hypothyroidism (4.79 %). Our study also concluded that the
percentage of patients with a comorbid condition was higher (59.68%) than those without a comorbid condition (40.31%). The mean
reduction in CT-Score in the comorbid and nil-comorbid was found to be 9.38 ± 2.85 and 7.08 ± 2.89. The mean reduction in hospital
stay in the comorbid and nil comorbid group was found to be 9.50 ± 2.34 and 8.08 ± 1.71. The mean reduction in RT-PCR was 10.04 ±
2.95 and 7.44 ± 2.33 in the comorbid and nil comorbid group respectively. Therefore, the RT-PCT, duration of hospital stay and CTChest Score showed a statistical si
Nanosponges: Blooming NDDS in the Future perspective
Authors: Singh Alka , Chauhan Chetan Singh
Published: November 2021

From the history of human civilization, it has been noted that the microorganisms are the cause of various pandemics and epidemics.
Among all microorganisms viruses are notorious. Viruses are intracellular parasites having RNA and DNA as their genetic material.
When these disease-causing viruses enter in host cell they start, to replicate and cause chronic illnesses. In such conditions antiviral
drugs are used to inhibit the activity of these viruses to prevent the illness. From the previous data of development of antiviral therapy,
it is found that nanotechnology plays a vital role in the development of nanomedicines in this field, the major problem arises is the
development of resistance by the viruses for certain drugs. Nanosponges is a new drug delivery system of a combination of science
and engineering in the area of medicine that full fill the current state of treatment of various life-threatening diseases. The
nanomedicines comprise nanoparticles to advanced nanosponges which enables the use of biocompatible nanomaterial in treatment
and prevention of various severe disease like SARS Covid-19. Therefore, researchers are focusing on the new aspect of drug
development. This review focuses on the various advancement of nanosponges to develop suitable antiviral therapy to combat
undesirable effects of SARS, Covid-19.
Dietary Supplementation of Nanomaterials Additives in Aquaculture - A Review
Authors: Seerengaraj Vijayaram , Sun Yun Zhang , Maruthupandy Muthuchamy , Kannan Suruli , Seerangaraj Vasantharaj
Published: November 2021

Aquaculture is the best growing food production division in the globe. Infection outbreaks are also a most important problem for the
aquaculture productions. Different types of technological development are uses to improve healthy aquaculture production and
enhance the aquatic environment. Nanotechnology is most significant tool for the development of aquatic productions. These
techniques are used to detect the infection at short time, deliver the vaccine, drugs and feed for aquatic animals. This review provides
information about dietary feed with supplementation of different nanomaterials such as copper, selenium, magnesium, manganese,
iron, zinc, chromium, chitosan is utilized to enhance immune system, digestive function, disease resistance, antioxidant activity,
growth performance, survival, regulate the metabolic functions, gut health, bio availability, feed intake, feed conversion of diverse
aquatic animals. These nanomaterials are mainly focused to improve the nano-nutrient in the feed supplements in aquaculture and enhance the healthy aquatic production.
Evaluation of Hepatoprotective and in vivo Antioxidant Potentials of Methanol Extract of Tephrosia pumila against Thioacetamide Induced Liver Toxicity in Wistar Rats
Authors: C Ramesh , Rawal Pinkey , Pramanik Soma , S Shabana
Published: November 2021

The objective of the current investigation was performed to assess the hepatoprotective potentials and in vivo antioxidant properties
of methanol extract of Tephrosia pumila against thioacetamide induced liver damage in rats. The acute oral toxicity study of methanol
extract was determined as per OECD guidelines and the extract was proved to be safe up to the dose of 2000mg/kg. The total duration
of the study was 21 days and animals were divided into six groups. Hepatotoxicity was induced in the animals of all groups except
normal control by single dose administration of Thioacetamide(100mg/kg) at first day of the study followed by animals were treated
daily with standard drug sylimarin and methanol extract of Tephrosia pumila (100mg/kg, 200mg/kg and 400mg/kg) to respective
groups for 21 days. Variations in biochemical parameters like alanine transferase (ALT), aspartate transferase (AST), alkaline
phosphatase (ALP), total bilirubin, direct bilirubin, albumin, total protein, ions and others parameters like clotting time and weight of
the liver were considered to determine beneficial effect of the extract. At the end of the study liver samples were collected and
subjected to histopathological evaluation. There were significant variations in the above mentioned biochemical parameters in toxic
control animals treated with Thioacetamide alone while in the animals treated with methanol extract and standard drug silymarin,
all the parameters were normal possibly due to their beneficial property in protecting the liver against thioacetamide induced
hepatotoxicity. The results obtained in the above study suggesting that, the methanol extract of Tephrosia pumila possess significant
hepatoprotective activity.
Evaluation of Aqueous Extract of Alphonsea sclerocarpa for in vivo and in vitro Antidiabetic Potentials in Wistar Rats
Authors: N Ravi Shankar , Kishore Ram , SB Puranik
Published: November 2021

The purpose of current investigation was to investigate in vivo and in vitro anti-diabetic potentials of aqueous extract of Alphonsea
sclerocarpa leaves against alloxan induced diabetes in albino rats. Two in vivo and one in vitro methods were performed for the
evaluation of aqueous extract for antidiabetic activity. For in-vivo evaluation, diabetes was induced in albino rats by administering a
single dose of alloxan. The study was designed to test the acute effect of aqueous extract of Alphonsea sclerocarpa (AEAS) to reduce
blood glucose in OGTT. The chronic study of 21 days was performed against diabetic rats and blood glucose was determined at 1st
,
7
th, 14th and 21st day. In chronic in vivo study, serum parameters insulin, urea, creatinine, total cholesterol, triglycerides, ALT and AST
were also estimated at 21st day to determine the effects of aqueous and aqueous extracts on complications of diabetes mellitus.
Glucose uptake by hemidiaphragm assay was performed to test the ability of extract to utilize glucose. In Oral Glucose Tolerance Test,
standard glibenclamide and aqueous extract (200mg/kg and 400mg/kg) treated animals have shown significant reduction in blood
glucose at 90 mins but at 120 mins. In chronic model the aqueous extract effectively reduced blood glucose levels (P<0.001) at 14th
and 21st day of study in therapeutic groups and effect was comparable to that of standard. The extract could also significantly
(P<0.001) reduce concentrations of SGOT, triglycerides, cholesterol and urea in serum and significantly (P<0.001) increased the insulin
level in blood which proves beneficial effects of the extract in diabetes. The change in concentrations of SGPT and urea were less
significant (P>0.01). The presence of extract in glucose uptake assay could significantly increase utilization of the glucose by rat
hemidiaphragm. The aqueous extract of Alphonsea sclerocarpa possess significant antidiabetic properties against alloxan induced
diabetic animals.
A Meticulous Review on Coumarin Derivatives as a Marvel Medication for Thousands of Ailments
Authors: K.M Femy Maria , Antony Sneha , Babu Amala , B Vinod , P A Daisy
Published: November 2021

Coumarin derivatives have progressively enticed medicinal chemists because of their potential role in preventing and treating
ailments. They epitomize a key motif nucleus in heterocyclic chemistry and a privileged structure in medicinal chemistry because of
its extensive-range pharmacological activity. Regardless of the advancement in medicine over the past century, cancer is still remain
the prominent source of death in the world and it makes indispensible needs to synthesize the compounds with coumarin as the core
nucleus. Synthesis of various coumarin derivatives and evaluation of their pharmacological effects can perceive a solution to certain
enigmatic demands in health sector. This review article is fixated on different synthetic routes of coumarin nucleus containing
compounds. The review article also highlights different biological activities such as anticancer, antibacterial, anti- inflammatory, antihyperlipidemic and enzyme inhibition activities.
A Pharmacovigilance Study of Topical Acne Monotherapy with 0.1% Adapalene, and A Molecular Analytical Review of Adapalene in Evidence-Based Dermatopharmacological Treatment
Authors: Hazra Dr. Moumita
Published: November 2021

Acne vulgaris causes cosmetic impairment. User-friendly anti-acne monotherapy with adapalene has activity against the acne
pathophysiology, with very minimal adverse effects. Retinoids, like adapalene, are comedolytic and anti-inflammatory. This study was
conducted as a pharmacovigilance study of topical acne monotherapy with 0.1% adapalene, and a molecular analytical review of
adapalene in evidence-based dermatopharmacological treatment. A prospective, open- labelled study was done, on 75 patients, with
mild to moderate acne. Patients applied 0.1% adapalene topical monotherapy, once daily in the evening, over affected areas on the
face, and left overnight. Efficacy was measured by percentage reduction in non-inflammatory, inflammatory and total lesion counts
on 0, 15, 30, 60 and 90 days; and severity of lesions was assessed by Investigator’s Global Evaluation Scale and the occurrence of
adverse effects like erythyma, dryness, scaling, burning and pruritus, were assessed by the Local Irritation Scale, among the patients
receiving the monotherapy. An analytical review of the molecular pharmacology of adapalene in evidence-based
dermatopharmacological treatment was thoroughly performed. The patients showed highly significant reduction in total lesion
counts from baseline. No serious adverse effects were observed; and the observations were statistically non-significant. The
molecular analytical review described significantly effective evidence-based dermatopharmacological response mechanisms of
adapalene therapeutics. Topical 0.1% adapalene monotherapy was effective and safe, with significant evidence-based molecular
dermatopharmacological efficacy.
Reviewing the Analeptic Activity of Calcium Citrate Malate
Authors: Kwatra Bharat , Rumao Chelsea , Abrol Hiya , Gulati Ishika , Pradeep Pankaj , Bajpai Srashti
Published: November 2021

Calcium Citrate Malate’s (CCM) health benefits were patented over three decades ago. It is involved in calcium retention, in children
and adolescents. In adulthood, it is seen to promote the maintenance of bone health. In conjunction with vitamin D, CCM also
decreases the risk of bone fracture in aged people and ensures that postmenopausal women’s health is made better. CCM, unlike
other supplements, does not need to be taken along with a meal and is seen to deliver benefits to individuals of any age group. CCM
is usually used when the person has achlorhydria where the gastric acid secretion is reduced and there is an absence of an acidic
environment (required by calcium carbonate). Calcium citrate Malate possesses outstanding bioavailability properties and is a useful
extension to the calcium available presently, either for direct supplementation or for food fortification.
Pharmacological Effects of Lycopene- A Review
Authors: Kwatra Bharat , Rumao Chelsea , Kamboj Ankita , Nad Susmita , Tripathi Twinkle , Konar Ujjal
Published: November 2021

Carotenoids are pigments that are lipophilic in nature. Lycopene is an important dietary carotenoid that has been seen to be effective
in managing and treating various medical conditions. It has aliphatic properties. It can be isolated from watermelons, tomatoes, and
papayas. All the studies were examined separately according to need, like, dose determination, comparison with other similar
products, their concentration in body fluid and also their effectiveness at different sites and types of comorbidities. It can prevent
inflammatory and oxidative properties. Lycopene has pharmacological effects in diseases related to the central nervous system like
Epilepsy, Alzheimer’s disease, Parkinson’s disease along with this it also exhibits Cardioprotective and anti-microbial properties. It is
also noteworthy to mention that antioxidants help in protecting and preventing the condition of atherosclerosis.
Uso di sostanze psicoattive e performance compromessa sul lavoro
Authors: Aliberti Silvana Mirella , Ferrucci Giuseppe , Nigro Antonio , Della Corte Alfonso , Frammartino Rosetta , Santoro Emanuela , Turco Assunta , Boccia Giovanni , De Caro Francesco , Moccia Giuseppina , Capunzo Mario
Published: November 2021

Non tutte le persone possiedono le stesse competenze in materia di salute, non tutti sono in grado di organizzarsi e decidere rispetto a questioni riguardanti il proprio benessere psico-fisico, migliorarlo, trovare informazioni e comprenderle, assumersi la responsabilità della propria qualità della vita. Queste competenze non fanno parte del bagaglio esperienziale comune ma, come afferma l’OMS: «La salute è creata e vissuta dalle persone all’interno degli ambienti organizzativi della vita quotidiana: dove si studia, si lavora, si gioca e si ama» I fattori di rischio lavorativo non sono solo agenti chimici, fisici e biologici ma anche errori umani, procedure non corrette, comportamenti inadeguati. I lavoratori stessi possono risultare pericolosi per gli altri. Ciò accade quando essi presentano condizioni come: uso e abuso di alcol, farmaci o droghe; malattie neuro-psichiatriche (demenze, disturbi comportamentali, etc.), malattie infettive contagiose [5]. Il rischio per i terzi può essere maggiore in settori come la sanità, i trasporti, le forze armate e di polizia, gli impianti industriali ove si manipolino prodotti pericolosi. Ma, più in generale, in tutti gli ambienti di lavoro si possono registrare situazioni critiche per la presenza di lavoratori con gravi problemi comportamentali. La legislazione vigente nel nostro Paese ha recentemente previsto un più accurato controllo sui lavoratori che svolgono mansioni ad elevato rischio per sé e per gli altri, con l’obiettivo di disincentivare condotte pericolose. Si ritiene, tuttavia, che il principale strumento di contrasto delle dipendenze debba essere la sensibilizzazione degli interessati attraverso un’informazione chiara e completa, per ottenere luoghi di lavoro liberi dalle conseguenze negative legate al consumo di alcol e sostanze stupefacenti.
Cadute? No, grazie. Come nasce e si realizza un programma per prevenire le cadute in ambito ospedaliero
Authors: Zambrano Maria Virginia , Moccia Giuseppina , Nigro Antonio , Della Corte Alfonso , Giuseppe Giuseppe , Frammartino Rosetta , De Paola Vincenzo , Maisto Antonella , Turco Assunta , Borrelli Anna , De Caro Francesco
Published: November 2021

La “caduta” in ambito ospedaliero rappresenta uno dei più frequenti eventi avversi che può determinare conseguenze immediate o anche tardive, spesso gravi fino a condurre, in alcuni casi, alla morte del paziente. Ecco perché il Ministero della Salute nel 2011 ha emanato la Raccomandazione n. 13 “Prevenzione e gestione della caduta del paziente nelle strutture sanitarie” che si pone come strumento per la prevenzione delle cadute dei pazienti nelle strutture ospedaliere. Per tale motivo, la Regione Campania ha deciso, in accordo con le Aziende Sanitarie del territorio, di sviluppare e pubblicare il “Piano Regionale Prevenzione Cadute - Linee di indirizzo per le Aziende del Servizio Sanitario Regionale”. L’A.O.U. San Giovanni di Dio e Ruggi d’Aragona ha recepito le Linee d’Indirizzo Regionali e ha realizzato due delibere interne (n. 67/2018 e n. 318/2019), ponendosi come mission la realizzazione e la programmazione di un Progetto di gestione dell’evento “Caduta” all’interno dell’Azienda. L’obiettivo generale del Progetto di Prevenzione “Cadute? No, grazie” è ridurre l’incidenza delle cadute nei pazienti ricoverati. La comunicazione ha rappresentato un’attività trasversale necessaria per tutte le fasi del Progetto: dalla sua strutturazione fino alla parte comunicativa/informativa non solo tra gli operatori sanitari ma anche per i pazienti e i familiari.
Studio osservazionale del lavaggio mani in relazione all’utilizzo dei guanti
Authors: Russo Michela , Nigro Antonio , Moccia Giuseppina , Della Corte Alfonso , Ferrucci Giuseppe , Frammartino Rosetta , Maisto Antonella , De Caro Francesco , Boccia Giovanni , Santoro Emanuela
Published: November 2021

Una buona adesione all’igiene mani e un uso sapiente di guanti possono ridurre le infezioni e, di conseguenza, il contagio tra pazienti e personale sanitario, riducendo i tempi di degenza e assicurando una maggiore protezione sia ai pazienti che al personale sanitario è esposto alle Infezioni Correlate all’Ambiente (ICA). L’igiene delle mani rimane la prima misura da mettere in atto per garantire la decontaminazione delle mani dopo la rimozione dei guanti. Essa può essere effettuata tramite lavaggio convenzionale oppure utilizzando prodotti idroalcolici che risultano essere significativamente più efficaci. In aggiunta alla corretta igiene delle mani si sono valutati anche la conseguente riduzione dell’utilizzo dei guanti con minore impatto sulla spesa sanitaria.
Metodo PEER: Educare alla salute con nuove strategie
Authors: Blasio Pietro , Della Corte Alfonso , Nigro Antonio , Ferrucci Giuseppe , Frammartino Rosetta , Genovese Armando , Maisto Antonella , Turco Assunta , De Caro Francesco , Moccia Giuseppina
Published: November 2021

Secondo quanto riportato nel manuale Peer Education Training of Trainers Manual (2003) si definisce Peer Education: “il processo tramite il quale giovani con un’adeguata formazione e motivazione affrontano attività informali o organizzate con loro pari (simili in età, background o interessi) lungo un periodo di tempo, con l’obiettivo di sviluppare le loro conoscenze, attitudini, credenze e competenze permettendogli di divenire responsabili della propria salute e di poterla proteggere”. Quando si parla di Peer-Education si parla di una metodica di educazione non formale che rientra tra i metodi di apprendimento “a mediazione sociale”. In quanto metodica a mediazione sociale basa le proprie fondamenta sull’idea che l’ambito sociale in cui un individuo matura le proprie esperienze rappresenti una componente fondamentale nello sviluppo dello stesso e, conseguentemente, nel suo modo di approcciarsi successivamente agli eventi della vita quotidiana.
Progetto pilota per la stesura del PDTA Sepsi nelle aziende sanitarie
Authors: Prisco Sonia Elisa , Moccia Giuseppina , Cioffi Grazia , Nigro Antonio , Della Corte Alfonso , Ferrucci Giuseppe , Frammartino Rosetta , Maisto Angela , Turco Assunta , Petrocelli Antonio , Maiorino Cosimo , Borrelli Anna , Boccia Giovanni , De Caro Francesco
Published: November 2021

Le disposizioni contenute nel DL “Nuovo sistema di garanzia per il monitoraggio dell’assistenza sanitaria” del 12 marzo 2019, entrano in vigore a partire dal 1° gennaio 2020. Il Sistema di Garanzia, pur indicando dei criteri di standardizzazione, riconosce l’eterogeneità geografica interna alle regioni, che può incidere sulla capacità delle stesse di garantire livelli di assistenza in linea con gli standard nazionali. Alle singole Regioni è demandato, pertanto, il compito di individuare le criticità peculiari e di attuare degli interventi volti all’ottimizzazione dei servizi e delle risorse. La Regione Campania, con decreto n. 32 del 25 marzo 2019, approva il “Documento Tecnico di indirizzo sulla metodologia di stesura dei PDTA in Regione Campania”. Tale documento riconosce il PDTA (Percorso Diagnostico Terapeutico Assistenziale) quale “strumento indirizzato a migliorare l’appropriatezza clinica ed organizzativa nella gestione di pazienti affetti da specifiche malattie”. Il PDTA rappresenta, dunque, lo strumento con cui le Linee Guida nazionali e internazionali vengono contestualizzate alla realtà locale. In questo lavoro ci siamo posti l’obiettivo di offrire uno strumento volto a migliorare l’appropriatezza clinica ed organizzativa nella gestione del paziente affetto da sepsi. L’ottimizzazione dell’assistenza al paziente settico passa attraverso la costruzione di un percorso ben definito che include l’identificazione del paziente, delle corrette strategie terapeutiche, il timing delle procedure, l’individuazione delle responsabilità nell’atto assistenziale, la formazione del personale (preliminare e continua) e la rivalutazione e validazione del PDTA stesso. Il lavoro ha previsto l’integrazione delle competenze di molte figure professionali con diverse aree di competenza: Direzione Sanitaria, Responsabili del Rischio Clinico, personale medico e infermieristico di Area Critica (PS, OBI, Anestesia e Rianimazione, TI), Malattie Infettive, Laboratorio Analisi, Chirurgia Generale, Radiologia, provenienti da 4 strutture ospedaliere.
Nuova metodologia per proteggere gli studenti delle professioni sanitarie dalle ferite accidentali da punta e taglio durante il periodo formativo
Authors: Cuccaro Floriana , Moccia Giuseppina , Nigro Antonio , Della Corte Alfonso , Ferrucci Giuseppe , Frammartino Rosetta , Oro Rosa Rita , Aliberti Silvana Mirella , Boccia Giovanni , Santoro Emanuela , Petrocelli Antonio , Turco Assunta , Capunzo Mario , De Caro Francesco
Published: November 2021

Lo scorretto utilizzo di dispositivi medici taglienti o acuminati sono tra le pratiche assistenziali che mettono maggiormente a rischio la sicurezza sia del paziente che dell’operatore sanitario. Le lesioni accidentali da aghi o da lame costituiscono un importante rischio lavorativo degli operatori sanitari nel corso dell’attività quotidiana; di conseguenza, le punture ed il taglio accidentale devono essere collocate tra le priorità da affrontare in un programma di prevenzione teso a migliorare le condizioni di sicurezza sul lavoro per gli operatori sanitari, tirocinanti e studenti. Da questa premessa nasce l’esigenza da parte dell’Università, nell’adempiere all’obbligo di informazione, di formazione e di tutela degli studenti delle Professioni Sanitarie e di attuare programmi tesi alla percezione del rischio e alla conoscenza delle procedure di sicurezza. Scopo di questo lavoro è stato sia di fornire agli studenti delle professioni sanitarie un unico strumento atto a prevenire le ferite da taglio e da punta, e garantire la formazione e l’acquisizione di abilità in procedure che tengano conto della sicurezza del paziente e minimizzino il rischio clinico a cui sono sottoposti; sia di valutare la percezione che gli studenti delle professioni sanitarie hanno del rischio biologico da ferite da taglio e da punta e di individuare il numero di infortuni che si verificano durante le ore di tirocinio evidenziando il problema della sottonotifica di tali incidenti.
Un intervento di sanità pubblica: elaborazione di una campagna vaccinale anti-influenzale in operatori sanitari
Authors: Borelli Dario , Moccia Giuseppina , Borrelli Anna , Genovese Giovanni , Maisto Antonella , Nigro Antonio , Della Corte Alfonso , Ferrucci Giuseppe , Frammartino Rosetta , Turco Assunta , De Caro Francesco
Published: November 2021

La tutela della salute degli operatori sanitari è un argomento di estremo interesse per la comunità scientifica internazionale, che negli ultimi anni ha dato luogo a prolifiche ed interessanti analisi su quanto sia importante migliorare e potenziare tutte le misure di sicurezza atte a proteggere pazienti ed operatori sanitari. Il compito di chi si occupa della Prevenzione Sanitaria è innanzitutto di educare i lavoratori a tutte le misure atte a proteggere se stessi e gli altri. Molti studi internazionali descrivono il grande stress a cui sono continuamente sottoposti gli operatori sanitari che ha rilevantissime conseguenze nella loro salute fisica e mentale. È da sottolineare, appunto, come figure professionali di medici, ostetriche ed infermieri non sono “immuni” agli agenti patogeni con cui rischiano quotidianamente di entrare in contatto e, quindi, di sviluppare patologie infettive. Questo non solo comporta un danno diretto alla salute dei lavoratori, con possibilità di eventuali complicanze e cronicizzazione di eventuali patologie ma anche un danno sociale ed economico con perdita di giornate lavorative e, di conseguenza, danno all’utenza. Ma c’è un altro aspetto importante da analizzare: un medico o infermiere che entra in contatto con un agente infettivo può essere un subdolo veicolo di infezione e trasmettere l’agente infettivo a tutta l’utenza e, in particolare, a chi si trova in una situazione di immunodeficienze come anziani, donne gravide, neonati ed allettati. Questo studio da noi condotto presso l’A.O.U. “San Giovanni di Dio e Ruggi d’Aragona” coadiuvati dalla U.O.S.D. Sorveglianza Sanitaria e Radioprotezione, ha avuto come scopo la promozione, utilizzando strumenti e tecniche comunicative studiate ad hoc, e l’analisi dell’adesione al piano vaccinale antinfluenzale dei dipendenti dell’Azienda Ospedaliera confrontando i risultati con l’adesione degli anni precedenti.
Fast Fluid Thermodynamics Simulation by Solving Heat Diffusion Equation
Authors: Li Wanwan
Published: November 2021

In mechanical engineering educations, simulating fluid thermodynamics is rather helpful for students to understand the fluid’s natural behaviors. However, rendering both high-quality and realtime simulations for fluid dynamics are rather challenging tasks due to their intensive computations. So, in order to speed up the simulations, we have taken advantage of GPU acceleration techniques to simulate interactive fluid thermodynamics in real-time. In this paper, we present an elegant, basic, but practical OpenGL/SL framework for fluid simulation with a heat map rendering. By solving Navier-Stokes equations coupled with the heat diffusion equation, we validate our framework through some real-case studies of the smoke-like fluid rendering such as their interactions with moving obstacles and their heat diffusion effects. As shown in Fig. 1, a group of experimental results demonstrates that our GPU-accelerated solver of Navier-Stokes equations with heat transfer could give the observers impressive real-time and realistic rendering results.
IoT based Smart Irrigation System by Exploiting Distributed Sensorial Network
Authors: Faruk Md. Omar , Debnath Tarun
Published: November 2021

In this research the Internet of Things (IoT) based smart irrigation system is developed for large scale farming to ensure appropriate water management as well as to minimize unnecessary water utilization. This system can control water wastage for irrigation purpose by using wireless sensor network (WSN) and IoT. Each WSN node contains a unit of combined sensors which has been made by several external sensors such as soil moisture, soil pH, and temperature sensor along with Node MCU for data transmission in the cloud. Other nodes are distributed in the field to collect field data for different positions and this information is sent to the server. Data processing and analysis are performed according to the proposed algorithm. Obtained result as well as weather forecasting report is checked for three days from a developed android app. The accomplished result is sent to the farmers through SMS; depending upon the SMS, farmers take necessary steps for watering or not in the crops field through IoT. Using the particular sensors in this system along with microcontroller board plays an important aspect for bringing automation for a particular model. In this work wireless sensor technology in irrigation purposes can show the direction to the rural farming community to replace some of the traditional techniques.
Dealing Crisis Management using AI
Authors: Kee Wong Yew
Published: November 2021

Artificial intelligence has been a buzz word that is impacting every industry in the world. With the rise of such advanced technology, there will be always a question regarding its impact on our social life, environment and economy thus impacting all efforts exerted towards sustainable development. In the information era, enormous amounts of data have become available on hand to decision makers. Big data refers to datasets that are not only big, but also high in variety and velocity, which makes them difficult to handle using traditional tools and techniques. Due to the rapid growth of such data, solutions need to be studied and provided in order to handle and extract value and knowledge from these datasets for different industries and business operations. Numerous use cases have shown that AI can ensure an effective supply of information to citizens, users and customers in times of crisis. This paper aims to analyse some of the different methods and scenario which can be applied to AI and big data, as well as the opportunities provided by the application in various business operations and crisis management domains.