bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh kedisiplinan dan pelatihan kerja terhadap kinerja pegawai melalui kesejahteraan pegawai di kantor Bupati Pesisir Selatan
Authors: Putri Ratu Anisa
Published: March 2024

Kantor Bupati merupakan instansi pemerintah yang bergerak dalam bidang pelayanan yang berfungsi untuk informasi publik yang mewadahi berbagai kegiatan berkaitan dengan pengelolaan informasi publik, dokumentasi dan arsip, serta pengaduan dan penyelesaian sengketa. Untuk meraih manajemen yang baik, kinerja pegawai merupakan salah satu faktor penting dalam memperbaiki Kedisiplinan serta pelatihan kerja yang membuat pegawai merasa puas atas pekerjaannya. Pelatihan Kerja tentunya sangat dibutuhkan untuk dapat mendorong peningkatan kinerja pegawai, namun perlu juga diperhatikan kesejahteraan pegawai. Dengan adanya pelatihan kerja dan kesejahteraan pegawai yang baik diharapkan kinerja pegawai dapat meningkat. Maka dari itu penelitian ini bertujuan untuk mengetahui pengaruh Kedisiplinan dan Pelatihan Kerja terhadap Kinerja Pegawai melalui Kesejahteraan Pegawai, jumlah sampel pada penelitian ini adalah 92 responden dengan menggunakan alat analisis Smart PLS 3 dan teknik pengumpulan data pada penelitian ini dengan penyebaran kuesioner yang menggunakan skala likert. Temuan hasil penelitian ini menunjukkan bahwa yang paling dominan terhadap Kesejahteraan Pegawai adalah Kedisiplinan terdapat pengaruh positif dan signifikan, hal tersebut menunjukkan semakin baik Kedisiplinan yang ditetapkan instansi maka kesejahteraan Pegawai juga akan meningkat. Sedangkan yang paling dominan terhadap Kinerja Pegawai adalah Pelatihan Kerja terdapat pengaruh positif dan signifikan, semakin banyak program Pelatihan Kerja yang diikuti Pegawai maka akan semakin meningkat kinerja pegawai. Pengaruh secara tidak langsung yang paling dominan adalah Kedisiplinan berpengaruh positif dan signifikan terhadap kinerja pegawai melalui Kesejahteraan Pegawai.
Problématique de l’écriture et de la lecture des écoliers qui terminent l’école primaire (Cas des écoliers de l’EP. AVOKI de la Sous-Provinciale éducationnelle Lodja I).
Authors: OKENGE LAMA Joseph
Published: March 2024

Résumé Par l’écriture l’enseignant développe l’attention visuelle assouplie la main de l’élève et permet à celui-ci d’établir la coordination entre ce qu’il entend et ce qu’il voit. Notre réflexion s’est portée sur l’autopsie de relever les causes et conséquences de la non maîtrise de notions de base de l’écriture et lecture par les écoliers de l’EP. AVOKI, Sous-provinciale éducationnelle de Lodja I. A l’issue de nos, nous avons constaté que la majorité d’écoliers ayant participé au test n’ont pas réussi car, les résultats en lecture et écriture en langue congolaise et française considérés comme les branches fondamentales sont en dessous de la moyenne. Les produits finis de l’école primaire AVOKI sont moins performants par ce que la majorité de nos enquêtés ont déclaré que les parents d’élèves ne veulent pas que leurs enfants doublent de classe et la carasse des exercices de lecture et de l’écriture constituent les causes majeures du non maitrise de lecture et écriture par les écoliers de l’EP. AVOKI de la sous-provinciale de Lodja I.
Ebauche théorique sur la femme et la parité
Authors: MUTOMBO NSALA Albert
Published: March 2024

Résumé Cet article aborde la problématique de la femme africaine face à la parité. Il y est question de l’analyse de deux concepts qui s’opposent diamétralement.
Fasciotomy done for vascular trauma at a tertiary care centre in Sri Lanka
Authors: ARUDCHELVAM JOEL
Published: March 2024

Introduction Compartment syndrome is a major factor contributing to limb loss and poor outcome following lower limb vascular injuries. Method This is a retrospective study done on patients with vascular injuries and undergone fasciotomy at the accident service operation theatre (ASOT) at the national hospital of Sri Lanka (NHSL), during a period of one year. Cases with Incomplete documentation were excluded. Data on patient demographics, time of injury, and time of fasciotomy, associated fractures, muscle viability and outcome were collected. Results A total of 30 cases were included. 26 (86%) were males. Nine (30%) were upper limb and 21(70%) were lower limb fasciotomy. The cause for limb injuries were road traffic accidents (RTA) in 18 (58.1%), trap gun injury in five (16.1%). All the fasciotomy were done prior to revascularization. 19 (63.3%) had fractures (12 (63%) were open and seven (36%) closed). six (20%) fasciotomy were done for compartment syndrome, 24 (80%) were done prophylactically. Three patients with compartment syndrome had open fractures (50%) and three had closed fractures (50%). On fasciotomy, in four cases all four leg compartment muscles were non-viable, two had non-viable three compartments and one patient had non-viable two compartments. The mean delay in patients who had all compartments viable was 3.7 hours (2-6.5) and the mean delay in patients with three or four non-viable compartments was 12.2hours (7-24). This difference was statistically significant (p-0.0001). The fasciotomy delay was also significant (p-0.0001) between the patients who had an amputation and limb salvage. Overall amputation rate was 20% in this series. Mean time of delay from admission to NHSL to the time of fasciotomy was 1.8 hours (1-3.5). Mean time of injury to time of fasciotomy was 5.42 hours (2-24). Discussion Number of non-viable compartments is significantly associated with the duration between time of injury to time of fasciotomy(P-0.0001). Therefore we suggest early fasciotomy before transfer
MARKETING COMMUNICATION STRATEGY PT. GO-JEK INDONESIA IN INCREASING THE NUMBER OF CONSUMERS
Authors: Lisdiantini Netty , Sufa Siska , Bindara Farah Zain Putri , Rohman Suhudi Rohman , Pradana Asya Pradana R
Published: March 2024

This study investigates the dynamic marketing and communication strategies used by PT. Gojek Indonesia to strengthen its consumer base. As one of Southeast Asia's leading technology-based platforms, Gojek has rapidly expanded its services beyond ride-hailing to include food delivery, digital payments, and more. This research uses a qualitative approach, combining interviews, case studies, and industry analysis to dissect the multifaceted strategy implemented by Gojek. This study explores Gojek's proficient use of digital channels and social media to drive consumer engagement. By analyzing consumer behavior and preferences, the study explains how Gojek tailors its marketing messages to resonate with diverse target audiences. In addition, this study examines the role of strategic partnerships and collaborations in strengthening Gojek's market presence and attracting new consumers. Furthermore, the study explores the impact of innovative features and services introduced by Gojek, such as loyalty programs and seamless user interfaces, on customer acquisition and retention. The study identifies the critical role of data analytics in shaping personalized marketing campaigns that appeal to specific consumer segments. The findings from this study contribute to a broader understanding of effective marketing and communication strategies in technology-based service industries. The insights derived from Gojek's approach provide valuable lessons for businesses looking to navigate a competitive market and expand their consumer base through strategic marketing initiatives.
प्रेस तथा नागरिक स्वतन्त्रता सूचकाङ्क
Authors: पाठक तिलक , दाहाल ऋषिकेश , केसी भुवन , प्रजापति उज्ज्वल
Published: March 2024

संविधान तथा नियम/कानुनमा वाक् तथा अभिव्यक्ति, प्रेस तथा नागरिकका अधिकारहरूको व्यवस्था गरिए पनि तिनीहरूको कार्यान्वयन अवस्थाबारे सम्बन्धित पक्षहरूको धारणा तथा बुझाइ के/कस्तो छ भन्नेबारे सर्वेक्षण गर्नुका साथै व्यवस्थित अध्ययन गरेको पाइँदैन । अभिव्यक्ति, प्रेस तथा नागरिक अधिकारहरूसम्बन्धी अन्तर्राष्ट्रिय विभिन्न संस्थाले पनि मापदण्ड बनाएर मूल्याङ्कन गर्ने गरेको परिप्रेक्ष्यमा नेपालमा प्रेस तथा नागरिक स्वतन्त्रताको अवस्था पहिचान गर्न यो सर्वेक्षणमार्फत मूल्याब्कन गरिएको हो ।
The Application of Attribution Theory in Understanding Women Workers' Perception of Occupational Health and Safety in the Metal Industry: A Focus Group Investigation
Authors: Aytac Serpil , Akalp Gizem
Published: March 2024

With the advent of the industrial revolution, women have become integral participants in the workforce, facing occupational risks similar to men. However, due to societal gender roles, women often encounter heightened psychosocial risk factors in the workplace, impacting both their attitudes towards work and societal roles. This study explores women workers' awareness of psychosocial risk factors within the Turkish metal industry. Employing attribution theories from social psychology, the study investigates negative attitudes towards occupational health and safety practices. Utilizing qualitative methods, data was gathered through focus group discussions with 155 female members of the Turkish Metal Union in Bursa, Turkey. The study evaluates factors such as job satisfaction, job stress, wellness, and relationships with coworkers and managers. Findings suggest that work stress and communication issues are significant psychosocial risk factors contributing to job dissatisfaction.
Exploring the Influence of Organizational Policy on Quality of Work Life and Employee Engagement in Nigerian Manufacturing Companies
Authors: Chiemeke Kingsley Chiedu , Ashari Hapriza BT , Muktar Syaharizatul Noorizwan BT
Published: March 2024

This study delves into the examination of organizational policies and their impact on the quality of work life (QWL) and employee engagement (EE) within manufacturing companies in Nigeria. It seeks to explore the factors within organizational policy that influence QWL and EE, both directly and indirectly. Historically, organizational policies have been formulated solely by management-level staff, yet there is a growing recognition of the benefits of involving all employees in policy formulation or review processes. Against this backdrop, this research investigates the relationships between organizational policy, QWL, and EE. The study assumes that organizational policy plays a significant role in shaping employee QWL and, consequently, their engagement. It identifies four key stages of organizational policy: formulation, adoption, implementation, and evaluation, highlighting the importance of employee involvement throughout these stages. The findings shed light on the importance of organizational policy and QWL in fostering employee engagement and emphasize the need for organizations to prioritize employee participation in policy-making processes.
Algunas reflexiones sobre el sistema educativo mexicano durante la pandemia por el COVID-19
Authors: Castro-García Verónica Rocío , Cáceres-Mesa Maritza Librada
Published: March 2024

El sistema mexicano a lo largo de la historia ha sufrido diversidad de cambios, los cuales se han reflejado en las prácticas de los docentes, los cuales, en la mayoría de los casos, no han sido considerados para participar en dichas reformas educativas, por lo que han tenido que asumir éstos desde sus saberes experienciales, un ejemplo es el reto que se enfrenta en este momento trascendental de la historia, como ha sido el caso de la transición a los escenarios virtuales durante el periodo de la pandemia por el Covid-19, cuyas exigencias ha demandado una adaptación para seguir con el propósito de educar con calidad y equidad, pero desde la virtualidad. Este trabajo tiene la finalidad de describir las características del Sistema Educativo Mexicano, con sus diferentes modificaciones a lo largo del tiempo hasta la actualidad, en donde se sigue demandando cambios por diferentes necesidades y en particular se han ido concretando en el ámbito de los diferentes periodos de gobierno.
Palabras clave:
Sistema educativo mexicano, organización curricular, COVID-19, dispositivos digitales.
 
ABSTRACT
The Mexican system throughout history has undergone a diversity of changes, which have been reflected in the practices of teachers, who, in most cases, have not been considered to participate in said educational reforms, so that they have had to assume from their experiential knowledge, an example is the challenge faced at this transcendental moment in history, as has been the case of the transition to virtual scenarios during the period of the Covid-19 pandemic , whose demands have demanded an adaptation to continue with the purpose of educating with quality and equity, but from virtuality. This work has the purpose of describing the characteristics of the Mexican Educational System, with its different modifications over time to the present, where changes are still demanded by different needs and in particular they have been specified in the field of the different periods. of government.
Keywords:
Mexican educational system, curricular organization, COVID-19, digital devices.
Editorial
Authors: León-González Dr.C. Jorge Luis
Published: March 2024

La investigación educativa desempeña un papel muy importante para la resolución de los problemas y desafíos que existen en los diferentes contextos sociales, en el cumplimiento de las políticas educativas y para lograr el perfeccionamiento de los sistemas educativos.
En el contexto educativo la investigación y la intervención son procesos interrelacionados que no coexisten de forma separada, pues no se puede investigar sin intervenir y a la vez no se puede intervenir sin obtener una transformación en el proceso de enseñanza-aprendizaje.
La Universidad Pablo Latapí Sarre, tiene el gusto de presentarle a la comunidad científica y académica de México y el mundo la Revista Mexicana de Investigación e Intervención Educativa. La revista es una publicación científica arbitrada que tiene el objetivo de contribuir al desarrollo de las ciencias de la educación en instituciones educativas de educación superior: nacionales, latinoamericanas y del mundo. 
Cuenta con una frecuencia cuatrimestral y se publica en los meses de abril, agosto y diciembre. Los artículos que publica son inéditos, de corte teórico y/o empírico, que abordan la problemática educativa de manera interdisciplinaria.
La revista divulga sus contribuciones a partir de la filosofía de Acceso Abierto (Open Access), donde el conocimiento es libre tanto en su difusión como en su acceso. Asimismo, provee ingreso libre e inmediato a su contenido bajo el principio de hacer disponible, gratuitamente, la investigación y fomentar el intercambio de conocimiento de manera global.
El consejo editorial de la Revista para la selección de los artículos que publica, se apoya en el método de Revisión por Pares Abierta (Open Peer Review). Todo ello, en función de garantizar la calidad de su contenido. La intención y el esfuerzo del consejo editorial es convertir esta publicación en referencia obligada de investigadores y docentes que deseen elevar su nivel científico en las ciencias de la educación.
Ciencia y tecnología en los procesos agrarios en Cuba durante la década de 1960
Authors: Guardado-Stuart Yariel , Fondeen-Veloz Dayana
Published: March 2024

Las transformaciones agrarias que se producen en Cuba en la década de 1960 van a tener un reflejo directo en diversos órdenes de la vida del país. En tal sentido, serán impactados no sólo la antigua estructura agraria sino también el ámbito económico, político, tecnológico, ideológico y cultural, siendo un catalizador en dichas transformaciones las reformas agrarias que se implementan en los años 1959 y 1963 respectivamente. Desde esta perspectiva, este artículo tiene como objetivo analizar el proceso de estructuración agraria llevado a cabo en Cuba a partir del triunfo de la Revolución y su impacto en el orden técnico y científico. Esta problemática ofrece múltiples miradas y vacíos que reclaman una profundización en los enfoques que se muevan en diferentes escalas, para entender por qué la aplicación de las leyes agrarias fueron catalizador en la modificación de las relaciones de producción en el agro cubano.
Palabras clave:
Reforma Agraria, tecnología agrícola, transformaciones agrarias.
 
ABSTRACT
The agrarian transformations that took place in Cuba in the 1960 will have a direct reflection on various orders of life in the country. In this sense, not only the old agrarian structure will be impacted, but also the economic, political, technological, ideological and cultural spheres, being a catalyst in these transformations the agrarian reforms that are implemented in 1959 and 1963 respectively. From this perspective, this article aims to analyze the agrarian structuring process carried out in Cuba since the triumph of the Revolution and its impact on the technical and scientific order. This problem offers multiple perspectives and gaps that demand a deepening of the approaches that move on different scales, to understand why the application of agrarian laws were a catalyst in the modification of production relations in Cuban agriculture.
Keywords:
Agrarian Reform, agricultural technology, agrarian transformations.
Número completo (Enero-abril)
Authors: León-González Dr.C. Jorge Luis
Published: March 2024

Editorial
Dr.C. Javier Moreno-Tapia
 
Fundamentos teóricos del desarrollo de competencias matemáticas en la Educación Básica Secundaria
Fabio Gómez-Moreno
 
Programa de preparación física para futbolistas adolescentes
Oscar Enrique Mato-Medina, Julio César Ambris-Sandoval, José Jesús Matos-Ceballos, Juan Prieto-Noa
 
Contenidos Educativos Digitales en el proceso enseñanza aprendizaje, estrategia para el desarrollo del aprendizaje significativo
María Concepción Monroy-Peña, Miriam Olvera-Cuellar, Juan Carlos Cruz-Resendiz, Alma Delia Vite-Rojo
 
La Educación Física y la práctica de ejercicio físico para la salud de la comunidad de Ciudad del Carmen, México
Lorena Zaleta-Morales, Juan Prieto-Noa, José Juan Carlos Jiménez-Camara
 
Aplicando el aprendizaje cooperativo en tiempos de post pandemia
Bianca Cecilia Camargo-Granados, Junueth Iridian Huizache-Corona, Mara Susana Osorio-Espinosa, Daniela Janeth Martínez-Quiroz
 
Transposición didáctica en el Museo de Ciencia y Naturaleza para alumnos de cuarto grado del Distrito Escolar de Gadsden y Las Cruces en Nuevo México
David Morales-Andrade
 
Ciencia y tecnología en los procesos agrarios en Cuba durante la década de 1960
Yariel Guardado-Stuart, Dayana Fondeen-Veloz
 
El teatro como estrategia didáctica de enseñanza de valores en niños en educación cristiana
Zuri Sadai Isidro-Acosta, Javier Moreno-Tapia, Irma Quintero-López
Análisis crítico del Sistema Educativo Mexicano. Apuntes y reflexiones
Authors: Gutiérrez-Romero Maribel
Published: March 2024

El Sistema Educativo Mexicano, a lo largo de su transitar a recurrido a múltiples programas y planes, para que respondan a las necesidades educativas que el país requiere, contando con un perfil de ingreso y egreso de la educación básica, que busca consolidar un mexicano que responda a las necesidades del país en cualquier ámbito, como político, social y económico. En el presente artículo se realiza un análisis de los programas usados desde la creación de la Secretaría de Educación Pública en México, hasta el programa analítico que se comenzó a conocer este año lectivo, con la intención que se aplique el siguiente ciclo escolar. Además de analizar que actualmente en educación primaria se trabaja con dos planes al mismo tiempo, incluso en algunas se esta haciendo prueba piloto del nuevo plan, lo cual en ocasiones a la comunidad escolar pueden confundirse, pues están acostumbrados a otros aprendizajes y estructura. Sin embargo, siempre se encuentra la forma de apropiarse de estos planes como una forma de continuar contribuyendo a la educación del país.
Palabras clave:
Plan, programa, estudio, reformas, educación.
 
ABSTRACT
The Mexican Educational System, throughout its transit, has resorted to multiple programs and plans, so that they respond to the educational needs that the country requires, with a profile of entry and exit of basic education, which seeks to consolidate a Mexican who respond to the needs of the country in any field, such as political, social and economic. In this paper, an analysis of the programs used since the creation of the Ministry of Public Education in Mexico is carried out, up to the analytical program that began to be known this school year, with the intention that it will be applied the following school year. In this article to analyzing that currently in primary education, two plans are being worked on at the same time, some are even doing a pilot test of the new plan, which can sometimes confuse the school community, since they are used to other types of learning and structures. However, there is always a way to appropriate these plans as a way to continue contributing to the education of the country.
Keywords:
Plan, program, study, reforms, education.
El desarrollo de capacidades y actitudes del pensamiento reflexivo en educación preescolar para favorecer el cuidado del medioambiente
Authors: Ortiz-Flores María Gabriela
Published: March 2024

En educación preescolar dentro el campo formativo Exploración y Comprensión del Mundo Natural y Social se pretende que los alumnos desarrollen capacidades y actitudes que caracterizan el pensamiento reflexivo. Ello implica considerar los aprendizajes esperados para diseñar diversidad de estrategias en donde los alumnos puedan participar en actividades de indagación, exploración y reflexión acerca de los fenómenos y procesos del mundo natural. Se espera que los niños vivan experiencias que favorezcan sus procesos de desarrollo y aprendizaje y gradualmente adquirir actitudes favorables hacia el cuidado del medio ambiente.
Palabras clave:
Pensamiento reflexivo, mundo natural, medio ambiente.
 
ABSTRACT
In preschool education, within the field of Exploration and Understanding of the Natural and Social World, it is intended that students develop capacities and attitudes that characterize reflective thinking. This implies considering the expected learning to design a diversity of strategies where students can participate in activities of inquiry, exploration and reflection about the phenomena and processes of the natural world. Children are expected to live experiences that favor their development and learning processes and gradually acquire favorable attitudes towards caring for the environment.
Keywords:
Reflective thinking, natural world, environment.
Número completo (Enero-abril)
Authors: León-González Dr.C. Jorge Luis
Published: March 2024

Editorial
Dr. C. Jorge Luis León-González
 
Fortalecimiento de hábitos de estudio para la formación científica en estudiantes de la Licenciatura en Física y Tecnología Avanzada en la Universidad Autónoma del Estado de Hidalgo
Abigail Sahagún-Villegas, Javier Moreno-Tapia, Maricela Zúñiga-Rodríguez
 
Configuración de dominios académicos, su relación con política científica, investigación y vinculación con la sociedad
Raúl Rodríguez-Muñoz, Alejandro Rafael Socorro-Castro, María Antonia Estévez-Pichs, Adalia Lisett Rojas-Valladares
 
Herramientas educativas gratuitas disponibles en la Web para el aprendizaje del Inglés
Anakaren Cruz-Pérez, Maritza Librada Cáceres-Mesa, Joaquín García-Hernández
 
Diagnóstico de comprensión lectora en alumnos de primer semestre de la Preparatoria San José del Valle, de la Universidad de Guadalajara
Christian Pulido-Sánchez
 
La inteligencia artificial y su influencia en el rendimiento académico de los estudiantes.
Celeste Alejandra González-Trejo, Kinberly Jazmin Julián-Ortega
 
Experiencia educativa: preservar la lengua Hñähñu desde el núcleo familiar con alumnos de preescolar indígena del Valle del Mezquital
Celia Selina Pérez-Pérez, Sandra Ameyalli García-Pérez, Antonia Olguín-Neria
 
El uso de Google Sites para el fomento de las competencias investigativas en educación universitaria
Shalom Zamar Yescas-Chávez, Javier Moreno-Tapia, Irma Quintero-López
 
Garantías laborales para mujeres embarazadas: perspectiva de género y protección reforzada desde la formación universitaria
Gustavo Xavier Corral-Calderón, Lucila Gómez-Rodríguez, Marcia Jacqueline Córdova-Díaz
 
El proceso legislativo en el Ecuador. Una mirada desde la formación
Cayetano Martínez-Avendaño
 
Evaluación de sustratos orgánicos para la propagación asexual de caña de azúcar (Saccharum officinarum) desde la Maestría de Agroecología de la Universidad Técnica Estatal de Quevedo
Manuel Benjamín Suquilanda-Valdivieso
The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions
Authors: Lee Mark S. , Tuohy Peter J. , Kim Caleb Y. , Yost Philip , Lichauco Katrina , Parrish Heather L. , Doorslaer Koenraad Van , Kuhns Michael S.
Published: March 2024

CD4
+
T cell activation is driven by 5-module receptor complexes. The T cell receptor (TCR) is the receptor module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling modules (CD3γε, CD3δε, and CD3ζζ) to form TCR-CD3 complexes. CD4 is the coreceptor module. It reciprocally associates with TCR-CD3-pMHCII assemblies on the outside of a CD4
+
T cells and with the Src kinase, LCK, on the inside. Previously, we reported that the CD4 transmembrane GGXXG and cytoplasmic juxtamembrane (C/F)CV+C motifs found in eutherian (placental mammal) CD4 have constituent residues that evolved under purifying selection (Lee, et al., 2022). Expressing mutants of these motifs together in T cell hybridomas increased CD4-LCK association but reduced CD3ζ, ZAP70, and PLCγ1 phosphorylation levels, as well as IL-2 production, in response to agonist pMHCII. Because these mutants preferentially localized CD4-LCK pairs to non-raft membrane fractions, one explanation for our results was that they impaired proximal signaling by sequestering LCK away from TCR-CD3. An alternative hypothesis is that the mutations directly impacted signaling because the motifs normally play an LCK-independent role in signaling. The goal of this study was to discriminate between these possibilities. Using T cell hybridomas, our results indicate that: intracellular CD4-LCK interactions are not necessary for pMHCII-specific signal initiation; the GGXXG and (C/F)CV+C motifs are key determinants of CD4-mediated pMHCII-specific signal amplification; the GGXXG and (C/F)CV+C motifs exert their functions independently of direct CD4-LCK association. These data provide a mechanistic explanation for why residues within these motifs are under purifying selection in jawed vertebrates. The results are also important to consider for biomimetic engineering of synthetic receptors.
Protein language model embedded geometric graphs power inter-protein contact prediction
Authors: Si Yunda , Yan Chengfei
Published: March 2024

Accurate prediction of contacting residue pairs between interacting proteins is very useful for structural characterization of protein-protein interactions (PPIs). Although significant improvement has been made in inter-protein contact prediction recently, there is still large room for improving the prediction accuracy. Here we present a new deep learning method referred to as PLMGraph-Inter for inter-protein contact prediction. Specifically, we employ rotationally and translationally invariant geometric graphs obtained from structures of interacting proteins to integrate multiple protein language models, which are successively transformed by graph encoders formed by geometric vector perceptrons and residual networks formed by dimensional hybrid residual blocks to predict inter-protein contacts. Extensive evaluation on multiple test sets illustrates that PLMGraph-Inter outperforms five top inter-protein contact prediction methods, including DeepHomo, GLINTER, CDPred, DeepHomo2 and DRN-1D2D_Inter by large margins. In addition, we also show that the prediction of PLMGraph-Inter can complement the result of AlphaFold-Multimer. Finally, we show leveraging the contacts predicted by PLMGraph-Inter as constraints for protein-protein docking can dramatically improve its performance for protein complex structure prediction.
Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice
Authors: Li Ang , Yi Jianxun , Li Xuejun , Dong Li , Ostrow Lyle W. , Ma Jianjie , Zhou Jingsong
Published: March 2024

Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by progressive weakness of almost all skeletal muscles, whereas extraocular muscles (EOMs) are comparatively spared. While hindlimb and diaphragm muscles of end-stage SOD1G93A (G93A) mice (a familial ALS mouse model) exhibit severe denervation and depletion of Pax7 + satellite cells (SCs), we found that the pool of SCs and the integrity of neuromuscular junctions (NMJs) are maintained in EOMs. In cell sorting profiles, SCs derived from hindlimb and diaphragm muscles of G93A mice exhibit denervation-related activation, whereas SCs from EOMs of G93A mice display spontaneous (non-denervation-related) activation, similar to SCs from wild-type mice. Specifically, cultured EOM SCs contain more abundant transcripts of axon guidance molecules, including Cxcl12 , along with more sustainable renewability than the diaphragm and hindlimb counterparts under differentiation pressure. In neuromuscular co-culture assays, AAV-delivery of Cxcl12 to G93A-hindlimb SC-derived myotubes enhances motor neuron axon extension and innervation, recapitulating the innervation capacity of EOM SC-derived myotubes. G93A mice fed with sodium butyrate (NaBu) supplementation exhibited less NMJ loss in hindlimb and diaphragm muscles. Additionally, SCs derived from G93A hindlimb and diaphragm muscles displayed elevated expression of Cxcl12 and improved renewability following NaBu treatment in vitro . Thus, the NaBu-induced transcriptomic changes resembling the patterns of EOM SCs may underlie the beneficial effects observed in G93A mice. More broadly, the distinct transcriptomic profile of EOM SCs may offer novel therapeutic targets to slow progressive neuromuscular functional decay in ALS and provide possible "response biomarkers" in pre-clinical and clinical studies.
Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells
Authors: Rinehart Leanna , Stewart Wendy E. , Luffman Natalie , Wawersik Matthew , Kerscher Oliver
Published: March 2024

Stem cells are critical for replenishment of cells lost to death, damage or differentiation. Drosophila testes are a key model system for elucidating mechanisms regulating stem cell maintenance and differentiation. An intriguing gene identified through such studies is the transcription factor, chronologically inappropriate morphogenesis (Chinmo). Chinmo is a downstream effector of the Jak-STAT signaling pathway that acts in testis somatic stem cells to ensure maintenance of male stem cell fate and sexual identity. Defects in these processes can lead to infertility and the formation of germ cell tumors. While Chinmo’s effect on testis stem cell behavior has been investigated in detail, there is still much to be learned about its structure, function, and interactions with other proteins. Using a two-hybrid screen, we find that Chinmo interacts with itself, the small ubiquitin-like modifier SUMO, the novel protein CG11180, and four other proteins (CG4318, Ova (ovaries absent), Taf3 (TBP-associated factor 3), and CG18269). Since both Chinmo and CG11180 contain sumoylation sites and SUMO-interacting motifs (SIMs), we analyzed their interaction in more detail. Using site-directed mutagenesis of a unique SIM in CG11180, we demonstrate that Chinmo’s interaction with CG11180 is SUMO-dependent. Furthermore, to assess the functional relevance of both SUMO and CG11180, we performed RNAi-mediated knockdown of both proteins in somatic cells of the Drosophila testis. Using this approach, we find that CG11180 and SUMO are required in somatic cells of adult testes, and that reduction of either protein causes formation of germ cell tumors. Overall, our work suggests that SUMO may be involved in the interaction of Chinmo and CG11180 and that these genes are required in somatic cells of the adult Drosophila testis. Consistent with the CG11180 knockdown phenotype in male testes, and to underscore its connection to Chinmo, we propose the name Chigno (Childless Gambino) for CG11180.
COMERCIO Y ESTACIONES INTERMODALES: CONFLICTOS EN EL ESPACIO PÚBLICO
Authors: Vecchio Giovanni , Mora Rodrigo , Figueroa Cristhian , Waintrub Natan , Ríos Roxana , Álvarez Martín
Published: March 2024

Las estaciones intermodales (EI) actúan como verdaderos subcentros urbanos, pues atraen grandes flujos de personas. Estos flujos suelen atraer comercio formal e informal, provocando conflictos en veredas y calzadas y afectando eficiencia y seguridad de las calles. A partir de un análisis de la estación intermodal Lo Ovalle (La Cisterna), realizado en el marco de un Laboratorio Urbano de CEDEUS, proponemos medidas para el re-diseño del espacio público de este tipo de espacios.
BURSA ULUDAĞ ÜNİVERSİTESİ KAMPÜS ALANI KURTARMA KAZISI BULGULARI
Authors: ALTIN Ahmet Ali , GÜLSEFA Gonca , KURU Buğra , ŞAHİN Mustafa
Published: March 2024

2018 yılında, Bursa Uludağ Üniversitesi kampüsü içerisinde, kampüsün güney kapısının bitişiğindeki yol yapım çalışmaları esnasında herhangi bir kültür varlığının bulunup bulunmadığını ortaya koymak amacıyla kazılar yürütülmüştür. Bu makalede bu kazılarla beraber ulaşılan sonuçlara yer verilmiş ve ortaya çıkan sorulara yanıtlar aranmıştır.

Toplam 3 sondajda yürütülen kazı çalışmaları sırasında, 1 sondajdan görece iyi korunmuş durumda iki adet kiremit çatkı mezar gün yüzüne çıkartılmıştır. Bu mezarlarda iskeletlerin yanı sıra profil veren seramik parçaları, tüm olarak ele geçmiş unguentariumlar ve bir adet sikke de bulunmuştur. Bu buluntular ışığında söz konusu mezarlar tarihlendirilmiştir. Makalede ayrıca, mezarların ait olduğu nekropol sahasının hangi yerleşim yerlerine ait olabileceği sorusuna da öneriler getirilmiştir.
TÜRKİYE’DEKİ GÜZEL SANATLAR LİSELERİ BAĞLAMA DERSLERİNDE ZEYBEK TEZENE TEKNİĞİNİN ÖĞRETİLME DURUMU ÜZERİNE TESPİTLER
Authors: APAYDIN Ali Kerem , ALGI Soner
Published: March 2024

Nitel bir durum çalışması olan araştırmanın amacı, öğretmen görüşleri aracılığıyla Türkiye’deki güzel sanatlar liselerinde yürütülen bağlama derslerinde zeybek tezene tekniği öğretiminin mevcut durumunu tespit etmektir. Bu amaca yönelik olarak farklı güzel sanatlar liselerinde bağlama derslerini yürüten ve görüşmeyi kabul eden 10 öğretmen ile 6 sorudan oluşan yapılandırılmış görüşme sağlanmıştır. Bu noktada, çalışma grubunda yer alan öğretmenlerin kaynak kullanımı, egzersiz ve etütlerden faydalanması, süreçte karşılaştıkları sorunlar gibi zeybek tezene tekniği eğitimine ilişkin gözlem ve görüşleri hakkında görüşme formu aracılığıyla veriler toplanmıştır. Elde edilen veriler betimsel analiz yöntemiyle analiz edilerek yüzde ve frekans değerlerini içeren tablolar ile ifade edilmiştir. Araştırma bulgularına dayanarak tartışma, sonuç ve önerilere yer verilmiştir.
KADİM AĞIT KÜLTÜRÜ VE ELBİSTANLI KADINLAR
Authors: KALKANDELEN Ayşe Hilal
Published: March 2024

Tarihi çok eskilere dayanan, ölüm, ayrılık ve doğal afetler sebebiyle insanların, özellikle kadınların üzüntülerini yansıttıkları ağıtların örneği olarak Elbistan ağıtlarını kapsayan bu çalışma, Elbistan’ın ağıt söyleyen kadınlarını tanıtmayı amaçlamaktadır. Ağıtlar; insanların geçmişi, yaşanmışlıkları, içlerinden atamadıkları duygularıdır. Bu çalışmada ihtiva ettiği edebî anlamlar açısından ele alınarak yakın geçmişimize kadar önemini sürdüren bir sözlü geleneğin varlığı, bilhassa Elbistan örneği üzerinden sunulmuştur. Ağıt, pek çok kişi tarafından ele alınmış olsa da ağıdın, acılarını içlerinde yaşamaya alışmış ve belki de alışmak zorunda bırakılmış kadınlarla olan ilişkisi yeterince irdelenmemiştir. Biz de bu boşluğu, kadınların hak ettikleri ihtimamın sorumluluğunu hissettiğimizden dolayı kapatmak istedik. Şairleri ve şiirleriyle edebiyat dünyasında mühim bir yer alan Elbistan, bu konuda yeterli kaynağa sahip olduğundan Elbistan’daki ağıt geleneğinin literatüre yeni bir bakış açısı getireceğine inanıyoruz. Bu çalışmada, ağıt türünde şiir söyleyen Elbistanlı kadın şairlerin ağıtlarından örnekler verilmiş, onların hangi konularda ağıt yaktıkları üzerinde durulmuştur.
ZAMAN VE DİLİN AYNASINDA: BATIYA YOLCULUK VE MİR’ATÜ’L-MEMALİK ESERLERİNİN KARŞILAŞTIRILMASI
Authors: AKBAŞ Cihat
Published: March 2024

Bu makalede, 16. yüzyıl Osmanlı denizcisi ve bilgini Seydi Âli Reis’in “Mir’atü’l-memalik” adlı eseri ile Çin klasik edebiyatının öne çıkan eserlerinden “Journey to the West” (Batıya Yolculuk) arasındaki dil bilimsel ve kültürel yönler incelenmiştir. Her iki eser de kendi coğrafyalarının ve dönemlerinin sosyal, kültürel ve bilimsel düşüncelerini yansıtan birer dil hazinesi olarak öne çıkar. “Mir’atü’l-memalik” Osmanlı İmparatorluğu’nun diller, gelenekler ve denizcilik bilgisi üzerine değerli bilgiler sunarken; “Journey to the West” Çin mitolojisi, Budizm ve edebî dilin gelişimi üzerine derinlikli analizler içerir.

Karşılaştırmalı analizimiz, her iki eserin dilsel yapı, anlatım teknikleri ve sembolizm açısından nasıl benzerlikler ve farklılıklar gösterdiğini ortaya koyar. Seydi Âli Reis’in eseri, denizcilik terimleri ve dönemin siyasi olaylarına özgü terimlerle zenginleşirken, Çin eseri fantastik öğeler, alegorik karakterler ve dinî öğretiye özgü kavramlarla doludur. Eserlerin dili ve anlatımı, o dönemlerdeki kültürel değerler ve inanç sistemleri ile yakından ilişkilidir ve bu da her birinin kendi coğrafyasının sosyal yapısını ve dönemin dünya görüşünü yansıttığını göstermektedir.

Ayrıca, bu çalışma her iki eserin de modern dil çalışmaları ve karşılaştırmalı edebiyat araştırmalarına olan katkılarını da değerlendirir. Bu eserlerin dilsel ve edebî analizi, modern Türkçe ve Çincenin tarihsel evrimine ışık tutarken, aynı zamanda gelecekteki araştırmalar için zengin bir veri tabanı ve analiz yöntemi sunar.

Sonuç olarak, “Mir’atü’l-memalik” ve “Journey to the West”, her ikisi de kendi dönemlerinin dünyasını ve dillerini şekillendiren kilit eserlerdir. Bu makalede yapılan analizler, dilin kültürel ve tarihsel bağlamda nasıl bir evrim geçirdiğinin ve edebiyatın bu süreçteki rolünün daha iyi anlaşılmasına katkıda bulunmayı amaçlamaktadır.
BAŞLANGICINDAN OSMANLI DÖNEMİNE ALEVİLİK TARİHİ TOPLUMSAL OLAYLARI
Authors: SAVAŞ Ersin
Published: March 2024

Aleviliğin kadim bir kültürü olduğu bilinmektedir. Bu kültürün şekillenmesinde Horasan’dan başlayıp Anadolu’ya kadar uzanan tarihî kesitin büyük bir payı olduğu anlaşılmaktadır. Söz konusu coğrafyada farklı birçok kültür ve inanışı bünyesinde birleştiren Aleviliğin senkretik bir yapıda olduğunu söylemek hata olmaz. Bu tespiti yapabilmek için de Aleviliğin tarihinin ana temaları çerçevesinde ele alınması gerekmektedir. Çünkü Horasan’dan Anadolu’ya uzanan coğrafyada bulunan birtakım kültürel motiflerin Alevilik yoluyla Anadolu coğrafyasına taşınması da meselenin başka bir yönü olarak belirmektedir. Bu durumu Anadolu coğrafyasında yaşanan toplumsal olaylarla ilişkilendirmek de pek tabii mümkündür. Alevilik tarihi içerisinde toplumsal olayların oldukça mühim olduğu tartışma götürmezdir. Çünkü ilgili toplumsal olayların; kültürü, edebiyatı ve düşünsel faaliyetleri önemli oranda şekillendirdiği görülmektedir. Bu motivasyondan hareketle bu çalışmada Alevilik tarihi başlangıcından itibaren Osmanlı Dönemi dâhil olmak üzere toplumsal olaylar ve sosyal bağlamları çerçevesinde değerlendirilmeye çalışılmıştır.
SCHOOL PRINCIPALS’ VIEWS ON THE IMPACT OF EMOTIONAL INTELLIGENCE (EI) ON PREFERENCES OF CONFLICT MANAGEMENT
Authors: GÜNÇAVDI ALABAY Gizem
Published: March 2024

This study aims to discover the relationship between Emotional Intelligence (EI) and conflict management within educational institutions, specifically focusing on school administrators' perspectives. Designed in phenomenology, the study encompassed 14 school principals from Turkish public schools, utilizing semi-structured interviews for data collection. Upon transcription and descriptive analysis, seven salient themes emerged. Findings clearly evinced the integral role of EI in conflict management, resonating with established EI paradigms, emphasizing aspects like empathy, self-awareness, and self-regulation. Moreover, the tangible link between EI and harmonious school cultures, efficient conflict resolution, and the generation of emotionally robust students was evident. In light of these revelations, the study proposes policy recommendations, including mandatory EI training for school personnel and the integration of EI frameworks into student curricula.
DİĞER BRANŞ ÖĞRETMENLERİNİN GÖRSEL SANATLAR DERSİNE YÖNELİK TUTUMLARI
Authors: KESER Nimet , NARİN KIZILTAN Handan
Published: March 2024

Bir toplumda sanatın değerinin ve gerekliliğinin anlaşılması, eğitim sistemine dâhil olan tüm öğretmenlerin sanat eğitiminin gerekliliğine ve değerine ilişkin inancıyla doğrudan bağlantılıdır. Sanat alanları dışındaki alan öğretmenlerinin görsel sanatlar dersine ilişkin tutumlarının saptanması, görsel sanatlar dersine ve sanat öğretmenlerine yönelik sosyal değerin saptanması için gereklidir. Görsel sanatlar dersinin ve görsel sanatlar öğretmenlerinin diğer branş öğretmenleri tarafından nasıl algılandığını incelemek amacıyla, Türkiye’nin farklı illerinde görev yapan görsel sanatlar öğretmenleri dışındaki alan öğretmenlerinden anket yoluyla veriler toplanmıştır. Araştırma sonucunda, bulgulara dayalı olarak diğer branş öğretmenlerinin görsel sanatlar dersi ve görsel sanatlar öğretmenlerine yönelik algıları değerlendirilerek, sonuç ve öneriler sunulmuştur. Araştırmanın sonucunda bazı maddelere verilen cevaplar diğer branş öğretmenlerinin görsel sanatlar dersinin müfredatta yer almasının gerekliliğine yönelik güçlü bir inanca sahip olduklarını gösterse de tüm maddelere verilen cevaplar birlikte değerlendirildiğinde görsel sanatlar dersinin amacı ve önemi konusunda bir kararsızlık, kafa karışıklığı ve tutarsız öğretmen tutumu olduğunu ortaya çıkarmaktadır.
KUTADGU BİLİG’İN EĞİTSEL DEĞERİNE YÖNELİK ÇALIŞMALAR ÜZERİNE BİR İNCELEME
Authors: BOZKIRLI Kürşad Çağrı , AVCİ Lütfi , ŞİMŞEK Bahattin
Published: March 2024

Bu araştırmanın amacı, Kutadgu Bilig’in eğitsel değerine yönelik çalışmaları bir araya getirmek, ilgili araştırmaları birtakım özelliklerine göre inceleyip değerlendirmektir.

Araştırma “Doküman İncelemesi” yöntemiyle yürütülmüş ve verilerin çözümlenmesi için “İçerik Analizi” tekniği kullanılmıştır. Tr Dizin ve Ulusal Tez Merkezi veri tabanları incelenerek yapılan alan yazını taraması sonucunda Kutadgu Bilig üzerine yayımlanmış olan çalışmalar içerisinden eserin eğitsel değerine yönelik yürütülmüş olan 21 makale, 8 yüksek lisans tezi, 2 doktora tezi tespit edilmiştir. Elde edilen veriler 5 farklı başlık altında tablolaştırılarak aktarılmıştır.

Araştırma sonucunda Kutadgu Bilig’in eğitsel değeri üzerine yapılan çalışmaların çoğunlukla 2017-2021 yılları arasında yoğunlaştığı, birçoğunda araştırma ve analiz yöntemlerinin belirtilmediği, belirtilenlerin ise nitel şekilde desenlendiği ve bu araştırmalarda toplanan verilerin içerik analiziyle analiz edildiği tespit edilmiştir.
Design of Pedal Powered Atta Chakki Based on Engineering Properties of Selected Food Grains
Authors: Yallappa D  , Mathad P F , Ambrish G  , Nidoni Udaykumar , Bai Roopa , Kavan Kumar V  , Ravi Y
Published: March 2024

The study was aimed to determine engineering properties of food grains which play an important role in the design of functional componenets of pedal-operated flour mill. The crops namely rice, pigeon pea, wheat, sorghum, and maize were selected for the study. Pedal operated flour mill comonents were designed and developed based on the variation of the engineering properties viz., size, shape, aspect ratio, volume, geometric mean diameter, sphericity, bulk density, true density, density, porosity, weight of 1000 grains, angle of repose, static coefficient of friction and hardness. These properties were determined and considered for the design of functional components viz., design of hopper, selection of drive mechanism, design of supporting frame, selection of grinding stones, power transmission, processing unit, safety, and ergonomics for easy and effective operation were made. The engineering properties are of great importance towards proper design, efficient process and equipment development. The developed pedal-operated flour mill is suitable for grinding almost all cereals and pulses to produce Rawa, Flour (Atta), and Dhal for human consumption and also for producing poultry/fish feed by grinding agro by-products and wastes.
A Study on Storage Stability of Brown Rice-Based Instant Khichdi Mix
Authors: Nishu  , Sood Monika , Bandral Julie D. , Gupta Neeraj , Duwa
Published: March 2024

The objective of the current research was to formulate the instant khichdi mix from processed brown rice (IBR) and dehulled mungbean (IDM) and to evaluate its minerals, bioactive components, microbiological and organoleptic parameters during storage of 90 days. Six composite instant khichdi mixes were formulated by taking different proportions of processed brown rice and dehulled mungbean in the ratios of T1 (100:00::IBR:IDM), T2 (90:10:: IBR:IDM), T3 (80:20::IBR:IDM), T4 (70:30::IBR:IDM), T5 (60:40::IBR:IDM) and T6 (50:50::IBR:IDM). The prepared instant khichdi mix was packed in aluminum laminates and stored under ambient conditions (32 \(\pm\) 2oC)for a period of 90 days. Results revealed that iron, calcium and potassium showed an increasing trend from 3.53 to 5.50, 26.65 to 67.82 and 256.40 to 700.68 mg per 100 g, respectively with the incorporation of processed dehulled mungbean. The maximum mean total phenolic content of 165.89 mg GAE per 100 g was recorded in treatment T6 (50:50::IBR:IDM). However, the maximum mean antioxidant activity of 46.12 per cent was recorded in treatment T1 (100:00::IBR:IDM). Sensory evaluation revealed that the highest mean overall acceptability scores of 7.91 was recorded in T5 (60:40:: IBR:IDM) which was adjudged as superior among all the treatments of instant khichdi mix. The formulated instant khichdi mix retained its quality throughout the storage period of 90 days with total microbial count within safe limits.
Effect of Steam Blanching and Storage Durations on the Physicochemical Properties of White Yam (Dioscorea rotundata) Slices
Authors: Alenyorege Evans Adingba , Raphael Lovette Ifunanya , Achaglinkame Matthew Atongbiik
Published: March 2024

White yam (Dioscorea rotundata) is a vital crop in many tropical regions, and its preservation and quality retention are of paramount importance for ensuring food security. This study investigated the impact of steam blanching and different storage durations on the physicochemical properties of white yam slices. White yam slices were subjected to varying steam blanching durations of 1 min, 3 min and 5 min, followed by oven drying at 60℃ for 72 hours and storage at room conditions for 7 days. Physicochemical properties such as proximate composition, total soluble solids, titrable acidity, moisture content, color and pH were measured before and after blanching. The results showed that the steam blanching durations significantly (p ˂ 0.05) affected all the physicochemical properties measured. The proximate results showed the non-blanched (control) samples had higher moisture (65.04±0.35), crude protein (4.55±0.04), fat (0.53±0.01), fibre (1.42±0.02) and ash contents (2.25±0.02) than the blanched samples with exception of the carbohydrate content (26.22±0.29) where the control samples had lower values. Proximate components decreased with blanching duration, except for carbohydrate content, while storage duration did not significantly affect the measured attributes, despite slight changes in moisture content, color, and pH. However, the duration of blanching and storage significantly impacted the physicochemical attributes. These findings have significant implications in the food processing industry, promoting the development of improved storage and preservation strategies for white yam and also ensure food security and reduced post-harvest losses.