bluuebunny/crossref_metadata_2025 huggingface dataset:
Kegiatan Marketing Public Relations Terhadap Proses Pengambilan Keputusan Pembelian Apartemen Pada Generasi Milenial
Authors: Wiradharma Gunawan , Anam Khaerul , Ningrum Karina Pramita
Published: March 2021

The construction and sale of apartments in big cities have increased, leading to competition between companies that sell or lease apartment units. Marketing public relations activities are important in encouraging consumers to attract prospective customers' interest in the decision-making process. The purpose of this research is how the influence of marketing public relations activities on the decision-making process of buying apartments in the millennial generation in an apartment in Depok City in October 2019. This research's indicators are publications, media identity, events, news, speeches, participation in social activities, and sponsorship. The purchase decision-making process indicators are the introduction of needs, information seeking, alternative evaluations, purchasing decisions, and post-purchase behavior. This research method is a quantitative and explanatory survey of tenants/buyers of the period in October 2019. This study concludes that marketing public relations activities positively influence the purchase decision-making process to buy Apartment X units in millennials.
Green Technology Accounting as an Innovation to Reduce Environmental Pollution
Authors: Sunarmin Sunarmin
Published: March 2021

The development of communication tools is part of the rapid development of information and communication technology. This change clearly influences communication patterns and relationships, for example in the field of work or business communication or organizational communication, education or learning communication, health communication, marketing communication primarily in marketing communication strategies, international communication, and others. Green accounting is a type of accounting that describes efforts to incorporate technology and environmental benefits and environmental costs into economic decision making or a financial outcome of a business. The aim is to find out whether green accounting technology can support the green movement of the business entity and the business continuity of the entity.This research is a descriptive study, using the library method where research is conducted by studying and collecting data from libraries related to tools, both in the form of journals and scientific studies of research that has been published in public journals.The results of the study concluded that the application of green technology and the impact of company activities need to be reported as a manifestation of corporate responsibility to stakeholders. The low awareness of reporting on environmental impacts is caused by several reporting constraints. The importance of environmental accounting needs to be done to improve green accounting technology that affects the positive value of environmental performance.
Concussion and the Brain Injury
Authors: Paul Satashree
Published: March 2021

Concussion is normally produced by acceleration/deceleration of head and is often characterized by a sudden brief impairment of consciousness, memory loss, and paralysis of reflex activity.
FEATURES OF THE RELATIONSHIP BETWEEN THE HORMONES OF THE THYROTRO-PIN-THYROID SYSTEM IN THE BODY YOUNG PIGS OF DIFFERENT SEXES AND BREEDS
Authors:   FSBEI HE ", Mekin R.S. ,   South Ural State Agrarian University", Derkho M.A. ,   FSBEI HE "South Ural State Agrarian University"
Published: March 2021

The assessment of the state of the thyrotropin-thyroid system in the body of young pigs in the context of sexual dimorphism and different breeds in specific economic conditions is given. It was found that the concentration of TTG, T3 and T4 in the blood of pigs varies in the range of 0.83±0.18-1.07±0.10 mMU/l, 5.76±0.33-7.14±0.41 and 26.82±2.90-28.73±0.93 pmol/l, boars 0.02±0.01-0.03±0.01 mMU/l, 7.50±0.25-9.24±0.34 and 25.74±4.63-31.67±2.43 pmol/l. The concen-tration of TTG and thyroxine is statistically significantly correlated in pigs at the level of r(TTG-T4)= 0,56±0,16 - 0,89±0,05, hryachkov r(TTG-T4)= 0,76±0,23 - 0,83±0,25). In a pair of TTG – T3 signs, the correlation coefficients are equal in pigs r(TTG-T3)= 0,47±0,09 - 0,51±0,17, hryachkov r(TTG-T3)= 0,49±0,39 - 0,64±0,54. Regulation in the TTG-T4 hormone pair, regardless of gender and breed of animals, is carried out on the principle of positive feedback (the higher the level of TTG in the blood, the greater the concentration of thyroxine). Functional communication in the TTG-T3 pair in the body of pigs and boars within the physiological scale of TSH concentrations is supported by the principle of direct and feedback, as well as the principle of "active regulation of vegetative func-tions".
TO THE ULTRASTRUCTURAL ORGANIZATION OF EPITHELIOCYTES OF EXOCRINE GLANDS
Authors:   FSBEI HE ", Momot N.V. ,   Primorsk State Agricultural Academy", Kolina Y.A. ,   FSBEI HE "Primorsk State Agricultural Academy", Kamliya I.L. ,   FSBEI HE "Primorsk State Agricultural Academy"
Published: March 2021

Pieces of the sublingual multi-duct salivary glands of a domestic sexually mature large white pig were fixed in a 4 % paraform solution in 0.1 M phosphate buffer (pH = 7.4) with addi-tional fixation in a 1 % OsO4 solution, dehydrated in alcohols of increasing concentration. Taking into account the recommendations of G. Gayer, pieces of organs were poured into araldite accord-ing to the standard technique. Contrasting was performed according to Reynolds. In the cytoplasm of the mucocytes of the sublingual multi-duct salivary gland, the agranu-lar endoplasmic reticulum predominates, which gives oxyphilic staining. According to electron microscopic studies of mucous glandulocytes in the acini of the sub-lingual salivary glands of domestic pigs, the secretory vacuoles of the cytoplasm are large, with pro-nounced electron-dense membranes. The content of vacuoles in mucocytes of one acinus is differ-ent.
PREVENTION AND CONTROL OF AFRICAN SWINE FEVER
Authors:   FSBEI HE ", Momot N.V. ,   Primorsk State Agricultural Academy", Kolina Y.A. ,   FSBEI HE "Primorsk State Agricultural Academy", Kamliya I.L. ,   FSBEI HE "Primorsk State Agricultural Academy"
Published: March 2021

As a result of laboratory investigations, the Rosselkhoznadzor Maritime Inter-Blast Veteri-nary Laboratory confirmed the presence of DNA from the African Pig Plague (ACS) virus in the wild and in private accessories in the Primorsky Territory. In all of 2019, 50 APC flares were recorded, although the province was previously consid-ered to be a APC success. Veterinary specialists of the Primorsky Krai region in April 2020 man-aged to eliminate all pockets of African plague of pigs. In April 2020, the Russian veterinary spe-cialists of the Primorskaya Krai region managed to eliminate all pockets of African pig plague. However, by mid-2020, Primorje experienced new outbreaks of APC, with 45 cases recorded by early autumn. The disease can occur at any time of the year. The source of the ACS causative agent is sick and sick pigs. Since the virus can spread not only with infected viral animals, including the incubation pe-riod, but also through various infected objects, the products of the infected pigs are particularly dangerous (meat, meat products, lard, blood, bones, hides, etc.). Virus-infected food and combat wastes used to feed pigs without careful venting have in most cases infected pigs with the African plague. Natural and legal persons who are the owners (owners) of pigs are obliged to carry out pre-ventive measures to prevent the emergence and spread of ACS.
RECEPTION TIMES AND CLINICAL DIAGNOSTICS OF DISEASES OF ORNAMENTAL AND EXOTIC ANIMALS
Authors:   FSBEI HE ", Nikitin I.N. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Trofimova E.N. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Nikiforova N.A. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: March 2021

The article presents materials on the regulation of labor of veterinary specialists who provide services to decorative and exotic animals. As an example for calculating the norms of time for ad-mission and clinical diagnostics, the calculations of the costs of working time for the clinical exami-nation of a rabbit, chinchilla, guinea pig, rat are presented; X-ray examination of the chest in a bird in 2 projections, ultrasound examination of the abdominal organs in a rat, taking blood from large and medium-sized parrots. There have been established 24 norms of time for admission and clinical diagnosis of diseases of decorative and exotic animals.
TIME REGULATIONS FOR CARRYING OUT PREVENTIVE ANTIEPISOOTIC MEASURES IN ORNAMENTAL AND EXOTIC ANIMALS
Authors:   FSBEI HE ", Nikiforova N.A. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: March 2021

The article presents materials on the regulation of labor of veterinary specialists providing services to decorative and exotic animals. As an example, the calculations of the time norms for vac-cination of ferrets against infectious diseases, deworming of rabbits, treatment of raccoons and rats against ectoparasites are given. Scientifically grounded norms of time of veterinarians for carrying out preventive antiepizootic measures among decorative and exotic animals have been established.
THE INCIDENCE OF BRUCELLOSIS IN ANIMALS AND ITS EPIDEMIC PROJECTION IN THE RUSSIAN FEDERATION
Authors:   FSBI ", Nurlygayanova G.A. ,   Central Scientific and Methodological Veterinary Laboratory", Belousov V.I. ,   FSBI "Central Scientific and Methodological Veterinary Laboratory", Varentsova A.A. ,   FSBI "Central Scientific and Methodological Veterinary Laboratory", Sharypov A.S. ,   FSBI "Central Scientific and Methodological Veterinary Laboratory", Grudev A.I. ,   FSBI "Central Scientific and Methodological Veterinary Laboratory", Skvortsova A.N. ,   FSBI "Central Scientific and Methodological Veterinary Laboratory"
Published: March 2021

In the Russian Federation, for the period from 2014 to 2019, the largest number of patients with brucellosis was detected among cattle – 55,591 heads and small cattle - 8,814 heads, which is 80.7 % and 12.8 %, respectively, of the total number of animals that respond positively to brucello-sis. Brucellosis of cattle was detected in 28 subjects of the Russian Federation, brucellosis of small cattle-in 8, brucellosis of horses in 9, brucellosis of pigs and deer (marals) in three subjects, respec-tively. In 2019, 397 cases of the disease were registered in the country.
SHOCK VOLUME OF BLOOD RATS EXPOSED TO DIFFERENT MOTOR MODES
Authors:   FSBEI HE ", Vasenkov N.V. ,   Kazan State Power Engineering University", Sviatova N.V. ,   FSBEI HE "Russian State University of Justice Kazan Branch", Valiyev R.M. ,   FSBEI HE "Russian State University of Justice Kazan Branch", Sadykova A.M. ,   FGAOU VO "Kazan (Volga Region) Federal University", Ratova E.N. ,   FGAOU VO "Kazan (Volga Region) Federal University"
Published: March 2021

The article provides data on the dynamics of the shock volume of blood of immature rats ex-posed to three modes of motor activity – unlimited, strengthened and sharply enhanced. The shock volume of blood rat rats in all the experimental groups we studied increases with age, but the in-crease depends on the mode of motor activity. The authors concluded that the mode of sharply in-creased motor activity has an inhibitory effect on the development of the shock volume of blood rats.
DIAGNOSTIC CRITERIA FOR RADIOGRAPHY AND COMPUTED TOMOGRAPHY IN ASSESSING SHOULDER JOINT PATHOLOGIES IN DOGS
Authors:   Federal State Budgetary Educational Institution of Higher Education “Moscow State Academy of Veterinary Medicine and Biotechnology - M.V. K.I. Scriabin ", Pavlovskaya E.A. , Pozyabin C.V. ,   Federal State Budgetary Educational Institution of Higher Education “Moscow State Academy of Veterinary Medicine and Biotechnology - M.V. K.I. Scriabin ", Starynina V.S. ,   Federal State Budgetary Educational Institution of Higher Education “Moscow State Academy of Veterinary Medicine and Biotechnology - M.V. K.I. Scriabin "
Published: March 2021

CT-scan can often be a method, which complements the information gaining from X-ray film deciphering because it allows to see a 3D image of bone tissue defect and soft tissue structure. In many arthropathies, which need a surgical operation, CT-scan is rather ordered after an X-ray for a surgical appointment.
FATTY ACID COMPOSITION OF ZOPHOBAS MORIO MEAL WORM AND HERMETIA ILLUCENS GARVES AND THEIR EFFECT ON LIVING WEIGHT OF YOUNG WHITE RATS
Authors:   FSBEI HE ", Papaev R.M. ,   Kazan State Academy of Veterinary Medicine named after N.E. Bauman ", Shalamova G.G. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine named after N.E. Bauman ", Motina T.Yu. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine named after N.E. Bauman ", Talan M.S. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine named after N.E. Bauman "
Published: March 2021

The article presents the results of studies of the fatty acid composition of Zophobas morio mealworms and Hermetia illucens larvae. It was found that the insects contained saturated and mono- and polyunsaturated fatty acids. Comparative analysis of insects showed that the most at-tractive in terms of unsaturated acids was the composition of mealworms, where sapienic, linoleic, oleic and cervonic fatty acids prevailed. More than 70 % of the larvae contained saturated fatty ac-ids with a significant proportion of lauric and myristic acids. It was found that the use of mealworms Zophobas morio and larvae of Hermetia illucens in live and dried form in feeding young white rats provided an increase in live weight by 12.1-16.7 and 11.4-14.0 % in comparison with control animals.
IMPROVEMENT OF THE PREOPERATIVE ECHOCARDIOGRAPHIC SCREENING METHODS IN DWARF BREEDS DOGS
Authors:   FGBOU VO ", Rudenko A.A. ,   Moscow State University of Food Production", Vatnikov Yu.A. ,   FGAOU VO "Peoples' Friendship University of Russia", Morozov I.A. ,   FGBOU VO "Moscow State University of Food Production", Rudenko P.A. ,   FGAOU VO "Peoples' Friendship University of Russia"
Published: March 2021

The article presents the results of assessing the informativeness of the improved technique of preoperative echocardiographic screening study in dwarf dog breeds. Evaluation of the ratio of the sizes of the left atrium to the root of the aorta, the pulmonary vein to the right branch of the pulmo-nary artery, normalized to the body weight of the end-systolic and end-diastolic dimensions, the fraction of the shortening of the left ventricle, the velocity of the peak E of the transmitral blood flow and the time of isovolumic relaxation makes it possible to carry out an effective preoperative assessment functional state of the cardiovascular system in dwarf dogs. These indicators do not de-pend on the body weight of dogs and characterize the state of remodeling, systolic and diastolic functions of the left chambers of the heart. Determination of the complex of these echocardiograph-ic parameters within 8-11 minutes makes it possible to assess the pumping function of the heart, to predict and reduce the risk of developing cardiogenic pulmonary edema.
BLOOD PROTEINS AND THEIR INFORMATIVENESS IN ASSESSING THE ADAPTIVE RESOURCES OF CHICKENS UNDER TECHNOLOGICAL STRESS
Authors:   FSBEI HE ", Sayfutdinova L.N. ,   South Ural State Agrarian University", Derkho M.A. ,   FSBEI HE "South Ural State Agrarian University"
Published: March 2021

In the body of chickens, when exposed to the technological factor (the density of birds in the cage), a stress reaction developed as a result of activation of the hypathalamic-pituitary-adrenal system. The response and state of the neuroendocrine pathway is associated with the magnitude of the technological stress factor. When it is increased by 1.50 times, the maximum changes in the body of chickens are detected 4 hours after the start of the experiment. At the same time, the level of corticosterone and cortisol in the blood of birds increases by 3.42 and 2.99 times, increasing the rate of catabolic reactions in protein metabolism. Therefore, the amount of total protein in the blood-stream of chickens increases by 34.32 %, albumins by 26.74 %, urea and uric acid by 2.07 and 2.29 times, and the activity of AsAT and AlAT increases by 2.15 and 4.53 times (p<0.05). The catabolic processes involve mainly blood albumins, whose nitrogen is used for the synthesis of uric acid. This is evidenced by a decrease in the value of Alb/uric acid by 42.74 % (p<0.05). With an increase in the density of birds in the cage by 2 times, the reaction of the GGNS more pronounced and long-lasting. Although the maximum changes are registered 2 hours after the initiation of stress, they per-sist throughout the study period. At the same time, the level of corticosterone and cortisol in the blood of chickens increases by 4.17 and 3.67 times, the concentration of total protein by 39.44 %, both due to albumins (by 41.78 %) and globulins (by 37.82 %); the increase in the amount of urea and uric acid is 2.18 and 2.45 times. Both albumins and blood globulins are subjected to oxidative decomposition, which determines the decrease in the ratio TP/Urea, Alb/urea at, TP/uric acid and Alb/uric acid at 35.72-43.18 %. At the same time, the activity of AlAT increases by 7.56 times and AsAT by 2.21 times, determining the predominant use of carbon residues of free amino acids in the processes of gluconeogenesis (AlAT/AsAT increased by 3.75 times).
THE MECHANISM OF ENDOCRINE REGULATION OF THE SEXUAL CYCLE AND THE NORMALIZATION OF REPRODUCTIVE FUNCTION IN THE HOLSTEIN HEIFERS
Authors:   FSBEI HE RGATU P.A. Kostycheva, Stepashin S.N.
Published: March 2021

In a large dairy company in the Ryazan region, studies of the mechanism of endocrine regu-lation of the estrial cycle were carried out, as well as ways of normalization of reproductive function were studied. Experimental data were obtained on the heifers of the Holstein breed of the same age. In a comparative aspect, the economic efficiency of the methods used is assessed. The drugs and methods used differed qualitatively from each other. For the first time, the combined use ofPGF Wakes Forte and Sedimin drugs has been proven to increase the probability of pregnancy in heifers of the same age by an average of 30 %.
PHYSIOLOGICAL AND IMMUNOLOGICAL PARAMETERS OF CALVES WHEN STIMULATING MOTHERS WITH THE IMMUNOMODULATOR AZOXIVET IN COMBINATION WITH SINESTROL 2 %
Authors:   FGBOU VO ", Terent'ev S.S. ,   Nizhny Novgorod State Agricultural Academy", Velikanov V.I. ,   FGBOU VO "Nizhny Novgorod State Agricultural Academy", Klyapnev A.V. ,   FGBOU VO "Nizhny Novgorod State Agricultural Academy", Chvala A.V. ,   FGBOU VO "Nizhny Novgorod State Agricultural Academy", Sletov A.O. ,   FGBOU VO "Nizhny Novgorod State Agricultural Academy", Larina Yu.V. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: March 2021

The aim of the study was to research the effect of Azoxivet in combination with Sinestrol 2 % on the development of calf resistance. The experiment was carried out in the Dalnekonstanti-novsky district of the Nizhny Novgorod region. To assess the effectiveness of the experiment, the first portion of colostrum was analyzed for Ig concentration, and to analyze the development of calf resistance, immunological, morphological and biochemical analyzes of the venous blood obtained before drinking the first portion of colostrum, one hour after drinking, the next day, on the 7th, 14th and days of life were performed. As a result, an increase in the fraction of γ-globulins in the blood of calves was recorded as early as an hour after drinking colostrum, and the peak of the indicator fell on the daily age. In addition, there was an active increase in the immunological parameters of calves.
EXTENT OF DISTRIBUTION DIGITAL DERMATITIS IN THE COWS ON THE FARM
Authors:   FSBEI HE ", Finogenova A.Р. ,   Ulyanovsk State Agrarian University named after P.A. Stolypin ", Ivanova S.N. ,   FSBEI HE "Ulyanovsk State Agrarian University named after P.A. Stolypin ", Ermolaev V.A. ,   FSBEI HE "Ulyanovsk State Agrarian University named after P.A. Stolypin ", Terentyeva N.Yu. ,   FSBEI HE "Ulyanovsk State Agrarian University named after P.A. Stolypin "
Published: March 2021

The aim of the work was to study the degree of spread of finger dermatitis in the conditions of the farm SPK named after N. K. Krupskaya in the Melekessky district of the Ulyanovsk region. A clinical study revealed 90 heads (7.5 %) with various stages of limb damage. Of these, 2 heads (0.16 %) were found with lesions of both hind limbs. Among all affected cows, the largest number were animals with the degree of M3 (48 %), and the smallest with the stage of M4 (14.4%). Among dry cows revealed: with the lesion stage M1 - 8 heads (25 %), M2 – 3 heads (9. %), M3 – 15 heads (47 %), M4 – 6 heads (18 %). The percentage correspondence of affected cattle, depending on the number of lactation, its stages and average daily milk productivity, remained in the range of 5-6 %. The increase in the number of diseased animals was measured. in addition, there was a sharp in-crease in the number of animals with both hind limbs affected (from 14.4 % to 20.5 % of the total number), which also indicates an aggravation of the development of the inflammatory process.
METHOD OF SELECTION COWS FOR MILKING ON A ROBOTIC INSTALLATION
Authors:   FSBEI HE ", Khisamov R.R. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Zagidullin L.R. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Kayumov R.R. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Lomakin I.V. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: March 2021

A new method of selecting cows for milking on a robotic milking installation is presented. The method includes a two-stage selection of first lactation cows. At the first stage, first-calf heifers are selected according to the optimal requirements for the udder. At the second stage, animals se-lected according to the number of voluntary milking. Animals that have this indicator less than the average for the herd by 1 sigma are rejected from the herd. Economic research has been carried out to test the method. It was found that 11 % of first-calf heifers were assigned to the cull group. They were milked 28.5 % less than animals of the main group. First-calf heifers of the main group surpass their peers in the culling group in terms of milk yield by 42.2 %.
THE EFFECTIVENESS OF THE USE OF FEED ADDITIVES IN THE DIET OF BROILER CHICKENS IN THE STUDY OF ITS PHARMACOLOGICAL PROPERTIES
Authors:   FSBEI HE ", Shantyz A.H. ,   Kuban State Agrarian University named after I.T. Trubilin ", Yeganyan E.S. ,   FSBEI HE "Kuban State Agrarian University named after I.T. Trubilin ", Luneva A.V. ,   FSBEI HE "Kuban State Agrarian University named after I.T. Trubilin ", Zholobova I.S. ,   FSBEI HE "Kuban State Agrarian University named after I.T. Trubilin ", Marchenko E.Yu. ,   FSBEI HE "Kuban State Agrarian University named after I.T. Trubilin ", Lysenko Yu.A. ,   FSBEI HE "Kuban State Agrarian University named after I.T. Trubilin "
Published: March 2021

The authors of this article evaluated the effectiveness of the use of a feed additive based on soy protein hydrolysate of the enzymatic cleavage method in combination with iodine and selenium in broiler chickens in the framework of studying its pharmacological properties. The indicators of livestock safety in the experimental group by the end of the experiment were 100.0 %, and in the control group − 84.0 %. In the experimental group, the increase in live body weight was 13.9 % higher compared to the group that did not receive a feed supplement. According to the calculations, the cost of compound feed per 1 kg of weight gain of poultry during the growing period in the ex-perimental group was 1.8 kg, which was 14.2 % lower compared to the control group. The slaughter yield of carcasses in the experimental group was 66.7 %, while in the control group − 62.0%. During the veterinary and sanitary examination, it was determined that the meat of the experimental and control group of broiler chickens was obtained from a healthy bird and was of good quality and suitable for further processing.
IMMUNOLOGICAL ASPECTS OF LEUKEMIA AND TUBERCULOSIS OF CATTLE
Authors:   FSBEI HE ", Yakupov T.R. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Zinnatov F.F. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Maslennikov N.N. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: March 2021

The results of studies of cow blood serum samples for the detection of anti-mycobacterial and anti-leukemic antibodies the article described. Samples were obtained from tuberculin-responsive and non-tuberculin-resistant animals, as well as animals infected and uninfected with BLV. The data proving that in more than 30 % of samples obtained from animals reacting to PPD anti-leukemia antibodies are found in ELISA and anti-mycobacterial antibodies in more than 40 % of RID positive samples.
INFLUENCE OF LEPTIN (LEP) GENE POLYMORPHISM ON DAIRY AND MEAT PRODUCTIVITY OF HOLSTEIN HEIFERS
Authors:   TatNIISKh FRC KazSC RAS, Gaynutdinova E.R. , Safina N.Yu. ,   TatNIISKh FRC KazSC RAS, Shakirov Sh.K. ,   TatNIISKh FRC KazSC RAS, Varlamova M.I. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: March 2021

The aim of this study was to research the association between leptin gene polymorphism in Holstein cows with their dairy and meat traits of productivity. To conduct DNA testing on the LEP gene blood samples were selected from 228 Holstein heifers. Animal genotyping according to the leptin gene was performed by AC-PCR. All possible genotypes of the LEP gene were identified in the course of DNA testing. Frequency of occurrence of genotypes and alleles was ranked as fol-lows: CC – 32.5 %, TC – 49.1 %, TT – 18.4 % and C – 0.57, T – 0.43. The results of this study show that animals with genotype TT of LEP gene can be useful in breeding for the improvement of population of Holstein cattle by economic traits associated to the dairy and meat productivity. This research was supported by the FASO Russia project АААА-А18-118031390148-1.
RESULTS OF STUDYING THE EMBRYOTOXIC ACTIVITY OF THE NEW COMPOUND "DS/16" IN WHITE RATS
Authors:   FSBEI HE ", Gizzatullin R.R. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Gizzatullina R.R. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Shangaraev R.F. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Lutfullin M.H. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: March 2021

The embryotoxic activity of the compound "DS/16" was studied in white rats. It was found that when intragastric administration of the drug "DS/16" in animals at a dose of 60 mg / kg (1/20 part of a single dose of LD50), from 5-10 days of pregnancy, does not significantly affect the fetal embryonic development in the antenatal and postnatal period.
IMMUNOBIOLOGICAL PROPERTIES OF AN ASSOCIATED VACCINE AGAINST IN-FECTIOUS KERATOCONJUNCTIVITIS OF CATTLE BASED ON ANTIGENS OF BACTE-RIA MORAXELLA BOVIS AND MORAXELLA BOVOCULI
Authors:   FSBSI ", Dupleva L.Sh. ,   Federal Center for Toxicological, Radiation and Biological Safety", Spiridonov G.N. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety", Khusainov I.T. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety", Makhmutov A.F. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety"
Published: March 2021

An associated vaccine against infectious keratoconjunctivitis in cattle based on the antigens of the bacteria Moraxella bovis and Moraxella bovoculi is presented. As antigens, the vaccine con-tains formalin-inactivated cell suspensions of bacterial strains Moraxella bovis «G97-VNIVI» and Moraxella bovoculi «SH-CH6-DEP» taken in the same proportions and the adsorbent is 6 % alumi-num hydroxide gel. The results of studying the immunobiological properties of an associated vaccine against cat-tle ICC based on antigens of bacteria Moraxella bovis and Moraxella bovoculi are presented. The data obtained show that the associated vaccine remained sterile, harmless and antigenically active during the observation period.
GRAMIN AND ITS TOXICOLOGICAL ASSESSMENT
Authors:   FSBEI HE ", Ivanovskiy A.A. ,   State Agrotechnological University", Timkina E.Yu. ,   FSBEI HE "State Agrotechnological University"
Published: March 2021

The aim of the research was to study the acute and subchronic toxicity of the drug gramine in white mice. The micromycete Drechslera graminea served as the basis for the creation of the gra-mine preparation. Experiments to determine the acute toxicity of the preparation gramine were car-ried out on outbred white mice (males) weighing 18-20 grams. The drug was administered to ani-mals intraperitoneally, once in doses from 400 to 2400 mg/kg. 6 mice were used for each dose. The condition of the animals was monitored for 14 days. The dose causing the death of 50 % of the an-imals (LD50) and the absolutely lethal dose (LD100) were determined. LD50 was calculated by the Kerber method. The study of subchronic toxicity of gramine was carried out for 30 days. The drug was administered to 10 mice intramuscularly daily, in the first 4 days, gramine was injected at a dose of 0.1 LD50, and then every 4 days the dose was increased 1.5 times and finally it was 1520 mg/kg. To determine the cumulative properties of the drug in white mice, a "subchronic toxicity" test was used. The reliability of the results obtained was taken into account in accordance with the Student's t-criterion at P <0.05. As a result, it was found that the average lethal dose (LD 50) of gramine for white mice is 1334 mg/kg, LD 100 - 2400 mg/kg. Studies of the subchronic toxicity of gramine showed that doses of the drug from 133 to 450 mg/kg did not cause significant changes in the behavioral responses of laboratory mice, and a pronounced toxigenic effect began to appear at a dose of 675 mg/kg and continued to increase after a further increase in doses of gramine (1013-1520 mg/kg), while causing mortality reaching the level of 50 %. It was found that gramine with intraperi-toneal administration of the LD50 of gramine for white mice corresponds to 1334 mg/kg, which al-lows the drug to be classified as a low-toxic substance. The cumulation coefficient of gramine is 1.14, which corresponds to the group of drugs with pronounced cumulation.
STUDY OF THE TOXIC EFFECT ON THE ORGANISM OF WHITE RATS AND RABBITS OF THE COMPOSITION OF MEDICINES
Authors:   FSBSI ", Idiyatov I.I. ,   Federal Center for Toxicological, Radiation and Biological Safety", Galyautdinova G.G. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety", Khalikova K.F. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety", Yamalova G.R. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety", Malaniev A.V. ,   FSBSI "Federal Center for Toxicological, Radiation and Biological Safety"
Published: March 2021

The article presents materials on the study of the toxicity of a complex of therapeutic and prophylactic agents, including choline chloride, succinic acid, xymedon, sorbitol, a suspension of lactic and propionic acid microorganisms, on the organism of laboratory animals in the experiment on white rats and rabbits. Based on the results of primary screening, the agent is recommended for eliminating the consequences of animal toxicosis, hepatoprotection and metabolic correction. Ac-cording to the results of the studies, it was found that this composition, in accordance with the ex-isting classification, is low-toxic, does not have a local irritating effect on the mucous membranes of the eyes and skin, does not possess cumulative properties, therefore, has prospects for further re-search.
INFLUENCE OF NANO-STRUCTURAL SAPROEL ON THE LIVING WEIGHT OF THE GOES AND THE QUALITY OF THEIR MEAT
Authors:   FSBEI HE ", Alimov I.F. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: March 2021

The article shows that the use of nanostructured sapropel in the form of feed additives in doses of 0.5-1.5 % to the dry matter of feed during the cultivation of geese contributes to an in-crease in their live weight by 7.9-11.1 % in comparison with control analogues. Also, the use of nanostructured sapropel as a feed additive at a dose of 1.0 % in the cultivation of geese showed the best results for increasing meat productivity. A physical and chemical study showed that the content corresponded to the required standards of cadmium and lead.
INCREASING NONSPECIFIC STABILITY OF SERVICE DOGS
Authors:   FSBEI HE ", Ishtudov A.A. ,   Chuvash State Agrarian University", Semenov V.G. ,   FSBEI HE "Chuvash State Agrarian University", Nikitin D.A. ,   FSBEI HE "Chuvash State Agrarian University", Ivanova E.N. ,   FSBEI HE "Chuvash State Agrarian University"
Published: March 2021

A biopreparation Dog-Stim-N-B was developed and a scientific and practical justification was given for its feasibility in the canine center for raising dogs of the German shepherd breed. Se-lective mobilization of morphological and biochemical profiles of blood, cellular and humoral factors of nonspecific resistance of dog organism is established against the background of intramuscular injection of first-tested biopreparation Dog-Stim-N-B and previously tested Prevention-N-E. The biologics used in the experiments showed a wide range of bio-effects: activated the production of red blood cells and increased the concentration of hemoglobin in the blood of dogs, that is, im-proved hematopoiesis, but did not have a stimulating effect on the production of white blood cells; caused physiological eosinophilia, moderate neutrophylopenia with neutrophilic nucleus shift to the right and lymphocytosis; increased protein metabolism, mainly due to synthesis of albumin and γ-globulin fractions; activated cellular and humoral factors of nonspecific resistance of the organism.
DYNAMICS OF CLINICAL AND BIOCHEMICAL INDICATORS OF BLOOD IN CORRECTION OF PAIN SYNDROME WITH "GABAPENTIN" AND "FLEXOPROFEN"
Authors:   Federal State Budgetary Educational Institution of Higher Education ", Klyukin S.D. ,   Saratov State Agrarian University named after N.I. Vavilov ", Salautin V.V. ,   Federal State Budgetary Educational Institution of Higher Education "Saratov State Agrarian University named after N.I. Vavilov ", Pudovkin N.A. ,   Federal State Budgetary Educational Institution of Higher Education "Saratov State Agrarian University named after N.I. Vavilov ", Salautina S.E. ,   Federal State Budgetary Educational Institution of Higher Education "Saratov State Agrarian University named after N.I. Vavilov "
Published: March 2021

The aim of this work was to study the dynamics of clinical indicators biohimicheskogo serum carnivores in the relief of pain drugs, "Gabapentin" and "Flexiprobe». For the study, a control group and two experimental groups were formed on the principle of pairs of analogues of 34 animals (17 dogs and 17 cats) in each. Intact animals (n=34, dogs-17, cats-17) were intramuscularly adminis-tered the drug "Sodium chloride 0.9 %" at a dose of 1 ml/kg at intervals of 24 hours for 7 days. An-imals of the experimental groups with pain syndrome were treated according to the following scheme: in the first experimental group (n=34, dogs-17, cats-17), the drug "Gabapentin" was used orally or rectally as a drug for the correction of pain syndrome in a dose of 10-60 mg/kg at intervals of 24 hours for 7 days, the optimal dose was selected depending on the type and severity of pain. In the second experimental group (n=34, dogs-17 heads, cats-17 heads), the drug "Flexoprofen" was administered subcutaneously or intramuscularly at a dose of 2 mg/kg at intervals of 24 hours for 7 days to correct the pain syndrome. The diagnostic marker of pain syndrome is a violation of electro-lyte metabolism in the blood serum in dogs and cats, characterized by a significant increase in sodi-um levels from 138.2±3.7 mmol/l to 194 ±4.2 mmol/l and a decrease in calcium levels to 2.4±0.7 mmol/l in dogs and 2.3±0.8 mmol/l in cats. The maximum therapeutic effectiveness of drugs with the least number of side effects is achieved by multimodal use of the drugs "Gabapentin"and " Flexoprofen".
EFFICACY OF PROBIOTIC PREPARATIONS IN SALMONELLOSIS OF BROILER CHICKENS
Authors:   FGBOU VO MGAVMiB - MVA named after K.I. Scriabin, Koba I.S. , Pchelnikov A.V. ,   FGBOU VO MGAVMiB - MVA named after K.I. Scriabin
Published: March 2021

We conducted experiments on the prophylactic and therapeutic effectiveness of the drugs Monosporin, Prolam and Bacell in the experimental infection of broiler chickens Salmonella enter-itidis. As a result, it was found that the use of probiotic agents Monosporin, Prolam and Bacell pre-vents the incidence of broiler chickens with salmonellosis of 66.7 %. The use of an antibacterial drug against the background of the use of probiotic agents in-creases the therapeutic effectiveness to 80 %, while when using only one antibiotic, its therapeutic effect was 57 %, which is 3 % lower compared to the group where only probiotic drugs were used.
MORPHOLOGY OF THE VENOUS SYSTEM OF KIDNEYS IN DOGS IN THE POSTNATAL PERIOD OF ONTOGENESIS
Authors:   FSBEI HE ", Matveev O.A. ,   Orenburg State Agrarian University", Torshkov A.A. ,   FSBEI HE "Orenburg State Agrarian University", Pashinin N.S. ,   FSBEI HE "Orenburg State Agrarian University"
Published: March 2021

The article presents data on the dynamics of morphometric parameters of the diameter of the caudal vena cava and renal veins of dogs in the postnatal period of ontogenesis, the peculiarities of the course and branching of extra- and intraorganic venous vessels of the kidneys of dogs, as well as the formation of the right and left renal veins in the gates of the organ. The increase in the diameter of the caudal vena cava and renal veins of dogs in the postnatal period of ontogenesis is uneven. An intense increase in the diameter of the caudal vena cava in dogs was detected at 3 months. and seven years. The diameter of the renal veins increases rapidly by 3 months. the age of the animals. In most cases, the intraorgan renal veins of the dogs on the right and left form one trunk of the efferent renal vein. The formation of the right renal vein in the gates of the organ occurs in three ways: two, three and four trunks, and the left renal vein by the fusion of two interlobar veins. The double trunk of the right renal vein is rarely recorded. The data obtained in the course of morphological study on the venous system of the kidneys of dogs can be used for op-erative access to organs.
PENGARUH FEE AUDIT, AUDIT TENURE, ROTASI AUDIT DAN REPUTASI AUDITOR TERHADAP KUALITAS AUDIT
Authors: Purnomo Listiya Ike , Aulia Jihan
Published: March 2021

This study aims to empirically examine the effect of audit fees on audit quality, the effect of audit tenure on audit quality, the effect of audit rotation on audit quality, and the effect of auditor reputation on audit quality. The population of this study is property and real estate companies listed on the Indonesia Stock Exchange (IDX) in 2013-2017. The research sampling technique used purposive sampling. The research samples obtained were as many as 25 property and real estate companies in 2013-2017. The analytical method used is logistic regression analysis. The results based on partial hypothesis testing indicate that audit fees affect audit quality and audit tenure affect audit quality. While audit rotation does not affect audit quality and auditor reputation does not affect audit quality. Keywords: Audit Quality, Audit Fee, Audit Tenure, Audit Rotation and Auditor Reputation
O Estado da Arte da Imunoterapia no Tratamento do Câncer de Mama Triplo-Negativo: Principais Drogas, Associações, Mecanismos de Ação e Perspectivas Futuras
Authors: Tavares Dione Fernandes , Cardoso-Júnior Laércio Moreira , Ribeiro Victoria Chaves , Britto Renata Lopes
Published: March 2021

Introdução: O câncer de mama e o mais comumente diagnosticado em mulheres e uma das principais causas de morte por câncer em mulheres em todo o mundo. Apesar, ou talvez por causa, de sua natureza agressiva e da falta de tratamentos direcionados atuais, pesquisas clínicas e laboratoriais significativas estão fornecendo opções de tratamento diferenciadas. Historicamente, a quimioterapia tem sido a única opção viável de tratamento sistêmico para doenças precoces e avançadas. No entanto, ensaios clínicos publicados recentemente mostraram que a imunoterapia tem um papel importante no paradigma de tratamento dessa condição devastadora. Objetivo: Demonstrar o estado da arte da imunoterapia no tratamento do câncer de mama triplo-negativo. Método: Revisão integrativa de literatura, entre janeiro/2020 a marco/2020, a partir das bases de dados PubMed, SciELO, International Clinical Trials Registry Platform e LILACS, por meio dos descritores “Imunoterapia”, “Neoplasias da mama” e “Neoplasias de mama triplo negativas” e seus respectivos correspondentes em inglês. Resultados: Foram encontrados 465 artigos; destes, 457 foram excluídos após aplicação dos critérios metodológicos. Assim, restaram oito artigos que atendiam aos critérios de inclusão, demonstrando os principais agentes terapêuticos utilizados, mecanismos de ação e combinações terapêuticas. Encontraram-se 25 ensaios clínicos em andamento na plataforma de registro de ensaios clínicos International Clinical Trials Registry Platform. Conclusão: Embora a imunoterapia seja algo recente, seus resultados com agentes inibidores da PARP, PD-1 e PD-L1 demonstraram resultados satisfatórios. Novos ensaios com subgrupos estratificados de acordo com biomarcadores tumorais específicos são necessários, a fim de avaliar se algum subgrupo tem maior benefício ao tratamento.
Association between weather factors and dengue in Dhaka: a time-series analysis
Authors: Shaheen Shafia
Published: March 2021

Background: There was an epidemic of dengue fever that happened  in Bangladesh  in the year of 2019. Temperature of this country has been raising which leads to changing in rainfall pattern. This study was aimed to investigate the relationship of weather factors and dengue incidence in Dhaka.

Methods: A time series analysis was carried out by using 10 years weather data as average , maximum and minimum monthly temperature, average monthly humidity and average and cumulative monthly rainfall. Reported number of dengue cases was extracted from January 2009 to July 2019. Firstly, dengue incidence rate was  calculated. Correlation analysis and negative binomial regression model was developed.

Results: Dengue incidence rate had sharp upward trend. Dengue incidence and mean, maximum and minimum average temperature showed statistically significant negative correlation at 3 months' lag. Highest incidence Rate Ratio (IRR) of dengue was found at minimum average temperature at 0 and I-month lag. Average humidity showed positive and significant correlation with dengue incidence at 0-month lag. Average and cumulative rainfall also showed negative and significant correlation only at 3-months lag period.

Conclusion: Weather variability influences dengue incidence and the association between the weather factors are non­ linear and not consistent. So the study findings should be evaluated area basis with other local factors to develop early warning for dengue epidemic prediction.

JOPSOM 2020; 39(1): 43-49
Corticosteroid treatment reduces headache in eosinophilic meningitis: a systematic review
Authors: Khamsai Sittichai , Sawanyawisuth Kittisak , Senthong Vichai , Limpawattana Panita , Chindaprasirt Jarin , Intapan Pewpan M , Maleewong Wanchai , Tiamkao Somsak , Chotmongkol Verajit , Ngamjarus Chetta
Published: March 2021

Background: Eosinophilic meningitis (EOM) is an emerging parasitic disease that can be found worldwide, of which acute severe headache is a presenting symptom. Although such headaches may persist for up to 2 months, studies have found corticosteroid to be effective in reducing this symptom. As the most recent systematic review was published in 2015, the aim of this study was to provide a more up-to-date examination of the role of corticosteroids in EOM.

Methods: We included randomized controlled trials of corticosteroid treatment for EOM regardless of comparators. Research articles published in five databases were searched and evaluated. The primary outcome was headache, which was compared among various treatment regimens.

Results: We found a total of 257 articles after duplication removal. Of those, two met the study criteria. According to these studies, oral prednisolone alone or in a combination of albendazole resulted in fewer patients with headache after a 2-week course of treatment compared with placebo (maximum of 9.1% vs. 45.5%). The duration of headache was also shorter in the prednisolone arm vs. placebo (maximum of 5 vs. 13 days). There were no serious side effects reported.

Conclusion: A 2-week course of treatment with oral corticosteroid with or without albendazole reduced headaches in patients with EOM.
Nutrition as prevention and treatment of osteoporosis
Authors: Stránský M , Ryšavá L
Published: March 2021

Osteoporosis is a systemic disease of the skeleton, characterized
by reduction of bone mass and concurrent deterioration of bone
structure. Consequently, bones are more fragile, and there is
increased risk of fractures. The potential for acquisition of
maximum bone mass is influenced by a number of factors.
Among those are heredity, sex, nutrition, endocrine factors,
mechanical influences and some risk factors. The best
documented nutrient for metabolism of bone is calcium. Major
role in the pathogenesis of osteoporosis have some micro and
macro nutrients, prebiotics, alcohol, alternative diets, starvation
and anorexia. Meta analysis of 29 randomized trials showed that
supplementation with calcium and vitamin D3 reduces risk of
bone fractures by 24 % and significantly reduces loss of bone
mass. Osteoporosis has multi factor etiology. Osteoporosis is one
of diseases which are influenced by nutrition and life style. It is
preventable by means of adequate nutrition and sufficient
physical activity.
Omega-3 fatty acids and cardiovascular disease risk: do we understand the relationship?
Authors: Vrablík M , Prusíková M , Šnejdrlová M , Zlatohlávek L
Published: March 2021

There is a large body of evidence documenting the effects of
long-chain polyunsaturated fatty acids with the first double bond
at the third position from methyl-terminal (so called omega-3
fatty acids (FAs)) on different components of cardiovascular
disease (CVD) risk. However, it may seem the more answers on
the topic we learn, the more questions remain to be elucidated.
There are three levels of evidence documenting the impact of
fish omega-3 FAs on CVD risk. Epidemiological data have shown
unequivocally the increased intake of fish is associated with lower
CVD morbidity and mortality. Numerous experimental studies
have shown (almost always) positive effects of omega-3 FAs on
lipoprotein metabolism, coagulation and platelet function,
endothelial function, arterial stiffness etc. Most importantly, there
are a few prospective clinical endpoint trials (DART, JELIS, GISSI
Prevenzione and GISSI-HF) that have examined the impact of
omega-3 FAs supplementation on cardiovascular outcomes in
different patient populations. Recent meta-analyses of these and
other clinical studies have yielded somewhat conflicting results.
In this review we will summarize current evidence of omega-3
FAs effects on cardiovascular risk focusing on new data from
recent clinical trials as well as possible practical implications for
clinical practice.