bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics of neurovegetative disorders in ischemic heart disease patients after coronavirus disease 2019 (COVID-19)
Authors: Manuilov S. M. , Mikhailovska N. S.
Published: April 2024

The aim of the study. To examine the frequency and spectrum of cognitive, anxiety-depressive, autonomic disorders and their interrelationship in patients with coronary heart disease (CHD) after COVID-19 infection.
Materials and methods. The study involved 71 patients with CHD, stable angina pectoris FC II–III (age 69.0 [64.0; 76.0] years): group 1 (main) – 31 CHD patients after COVID-19; group 2 (comparison) – 40 CHD patients without COVID-19 history. Spectral and temporal HRV parameters were assessed using 24-hour Holter ECG monitoring, anxiety-depressive disorders (ADD) – using the HADS scale, cognitive status of patients – according to the MoCa scale.
Results. CHD patients after COVID-19 had a higher frequency of ADD detection and a greater anxiety level (16 [10; 24] versus 10 [9; 13] points, p < 0.05), depression (14 [8; 20] versus 11 [10; 12] points, p < 0.05) as compared to patients without previous history of COVID-19. At the same time, the predominance of the anxiety component over the depressive one in patients of both groups has been revealed. In CHD patients after COVID-19, a decrease in the total MoCa scale score has been found as compared to patients without COVID-19: 24 [22; 26] versus 28 [26; 30] points, p < 0.05. There was an association between the total level of anxiety and depression and the severity of cognitive impairment (r = -0.36, p < 0.05). CHD patients exposed to COVID-19 showed an increased sympathetic and parasympathetic tone of the central nervous system within 24 hours, an increased LF/HF ratio during the active period, activation of slow-acting humoral regulation mechanisms amid increasing stress index and centralization index. In the group of patients with CHD after COVID-19, a wide range of correlations between the rate of ADD, cognitive disorders and HRV parameters has been found.
Conclusions. Patients with coronary heart disease recovered from COVID-19 have shown an increase in the incidence and degree of ADD and cognitive disorder manifestations which was accompanied by autonomic dysfunction resulting in stress on the functional and adaptive state of the cardiovascular system. The association between ADD, autonomic and cognitive disorders in patients with coronary heart disease after COVID-19 has confirmed the common pathogenetic links of the disorders found.
Immunohistochemical characteristics of epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma
Authors: Shyshkin M. A. , Kabachenko V. O.
Published: April 2024

The epithelial-mesenchymal transition (EMT) plays a crucial role in the development of pancreatic ductal adenocarcinoma (PDAC). There are insufficient and contradictory data in the scientific literature on the peculiarities of epithelial and mesenchymal marker expression in PDAC ducts and EMT zone, which requires further research on the role of EMT in the development and progression of PDAC.
Aim: to conduct a comprehensive assessment of epithelial and mesenchymal markers of EMT in the PDAC ducts and EMT zone at different degrees of differentiation.
Materials and methods. A comprehensive pathomorphological and immunohistochemical examination including 49 cases of surgical material from patients with PDAC, divided into groups of moderate (G2) and low degree of tumor differentiation (G3).
Results. PDAC was characterized by low levels of E-cadherin expression in both ducts and EMT – Me = 22.58 % [12.81; 36.23] and Me = 25.17 % [19.04; 35.37], respectively (p > 0.05). Only membrane expression of the marker was detected in the ducts and membrane-cytoplasmic one – in the EMT zone without significant differences in the groups. There was a significant decrease in the ductal β-catenin expression (p < 0.05) in G2 with membrane-cytoplasmic staining (Me = 15.58 % [10.42; 26.24]), in G3 – with membrane (Me = 4.42 % [2.35; 5.93]); in the EMT zone, only membrane-cytoplasmic expression was observed in both groups without significant difference (p > 0.05). Membrane expression of CK7 was positive in 100 % of PDAC, significantly lower at G2 (Me = 19.51 % [10.70; 27.24]; Me = 26.19 % [20.93; 30.05], p < 0.05), and CK18 (Me = 21.34 % [9.68; 29.96] – in G2, in G3 – Me = 22.50 % [8.24; 40.08], p > 0.05). Expression of α-SMA and Vim was seen in spindle-shaped stromal cells, around tubular and trabecular structures with membrane-cytoplasmic staining. There was no significant difference between α-SMA in G2 and G3, the level of vimentin was significantly lower in G3 (p < 0.05).
Conclusions. The features of PDAC E-cadherin, β-catenin, CK7 and CK18 marker expression indicate a greater EMT process at the periphery of the tumor and its severity increases with tumor progression. The optimal markers to determine the mesenchymal phenotype of PDAC cells are α-SMA and vimentin.
Study of factors influencing the occurrence of conflicts in pharmacies
Authors: Zarichna T. P. , Chervonenko N. M. , Brahar N. O.
Published: April 2024

The aim of the study was to investigate the factors influencing the occurrence of conflicts in pharmacies during the provision of pharmaceutical care, with the subsequent goal of optimizing the social and psychological climate within the team and improving the quality of service to the population.
Materials and methods. Systematic-analytical, mathematical statistical, comparative, and sociological research methods were employed in the study. Descriptive statistics were utilized to present the obtained data. To assess the significance of individual factors, the questionnaire results were converted into corresponding component weights (Wij).
Results. The study of conflicts between visitors and pharmacy employees, from the point of view of visitors, revealed several key findings. Most customers expressed dissatisfaction with the prices of medicines and medical devices (Wij = 1.00). Additionally, there were concerns about the perceived quality of the products (Wi j= 0.67), and some customers reported feeling distressed due to the unavailability of necessary medicines (Wij = 0.57). The study, conducted from the point of view of employees, focused on conflicts between employees and visitors. The findings revealed that conflicts most often arise due to dissatisfaction with the prices of medicines and medical devices (Wij = 1.00). Additionally, issues such as requests to dispense over-the-counter medicines from the list of prescription drugs (Wij = 0.70) and returning medicines to the pharmacy after purchase (Wij = 0.67) were identified as contributing factors. The analysis of factors that provoke conflicts in the pharmacy team revealed several key contributors. The most significant include the inadequate behavior of employees (Wij = 1.00), inconsistency in words, assessments, and actions of some team members with the expectations and requirements of others (Wij = 0.89), and psychological incompatibility between employees (Wij = 0.88). The study of conflicts between the administration and subordinates in the pharmacy revealed frequent occurrences linked to several factors. Most notably, conflicts were associated with an imperfect bonus system (Wij = 1.00), high workload (Wij = 0.92), and a perceived lack of career development opportunities (Wij = 0.76).
Conclusions. The factors that contribute to the emergence of conflict situations in pharmacies have been identified and studied. Approaches to preventing and resolving conflicts by pharmacy employees are proposed.
Investigation of antioxidant interaction between ascorbic acid and rutin in medicine “Ascorutin”
Authors: Maslov O. Yu. , Komisarenko M. A. , Kolisnyk S. V. , Golik M. Yu.
Published: April 2024

Phytomedicines are combined pharmaceuticals containing various groups of phenolic compounds. It is known that phenolic compounds are powerful antioxidants, but their level of antioxidant activity during interactions has not been previously studied.
The aim of the work was to investigate interaction between ascorbic acid and rutin in medicine “Ascorutin”.
Materials and methods. The objects of the study were one series of tablets “Ascorutin,” rutin, and ascorbic acid. The level of antioxidant activity was measured by the potentiometric method.
Results. The level of antioxidant activity of model solutions of rutin was 265.51 ± 1.00 mmol-eq./L, ascorbic acid – 99.00 ± 1.00 mmol-eq./L, a combination of rutin and ascorbic acid – 255.60 ± 1.00 mmol-eq./L, and medicine “Ascorutin” – 256.52 ± 1.00 mmol-eq./L. An experimental value of the level of antioxidant activity of “Ascorutin”, the combination of rutin and ascorbic acid was 30 % less than theoretical values.
Conclusions. The antioxidant interaction of ascorbic acid and rutin in “Ascorutin” medicine has been studied. It has been established that the combination of rutin and ascorbic acid has an antagonistic effect. The findings of this research will serve as a stimulus for exploring the interaction of bioactive substances and selecting their optimal combinations for the development of pharmaceuticals, special food products, food, and cosmetic products.
Identification and analysis of the expression of genes, involved in insulin signals transmission in the development of experimental type 2 diabetes mellitus
Authors: Ivanenko T. V. , Vynokurova A. V.
Published: April 2024

Type 2 diabetes mellitus is a significant concern due to its high prevalence and impact on global health. Ongoing scientific research aims to enhance our understanding of the mechanisms involved in the development and progression of diabetes and devise effective strategies for its treatment. This involves the development of new pharmacological treatments, including novel antidiabetic drugs, and the exploration of individualized approaches to therapy.
The mechanisms underlying type 2 diabetes are intricate, involving various aspects of physiology and biochemistry. Gaining insight into the development and progression of type 2 diabetes mellitus through modern laboratory diagnostic methods is crucial for the development of effective treatment and prevention strategies for diabetes.
The aim of the study is to identify and analyze a panel of genes, involved in insulin signals transmission in the development of experimental type 2 diabetes mellitus.
Materials and methods. The analysis of gene expression involved in insulin signal transmission was conducted using real-time reverse transcription-polymerase chain reaction (RT-qPCR) on the CFX-96 Touch™ system (Bio-Rad, USA). The RT2Profiler™ PCR Array Rat Diabetes kit (QIAGEN, Germany) was employed for this purpose.
Results. Based on the study results, the activity of the genes involved in insulin signal transmission can be categorized as follows: genes with low expression compared to the control group of animals, where ∆∆Ct <30 (Akt2, Mapk14, Pik3r1); genes in which no significant changes were detected in the samples compared to the control group (Irs1, Irs2, Pik3cd); no genes with high expression were observed compared to the control group.
Conclusions. In the development of experimental type 2 diabetes mellitus, genes involved in insulin signal transmission (Akt2, Mapk14, Pik3r1) exhibited significantly low expression levels (Akt2 – 2.9, Mapk14 – 5.01, Pik3r1 – 8.87) where ∆∆Ct <30, compared to the control group of animals. Conversely, no significant changes were observed in the expression of genes Irs1, Irs2, Pik3cd, also involved in insulin signal transmission, during the development of experimental type 2 diabetes mellitus, compared to the control group of experimental animals.
The choice of surgical correction method depending on the etiology of decompensated chronic venous insufficiency
Authors: Rusyn V. I. , Pavuk F. M. , Rusyn V. V. , Borsenko M. I.
Published: April 2024

Aim. To evaluate the immediate and distant results of treatment depending on the etiology of chronic venous insufficiency in the stage of decompensation.
Materials and methods. This work presents an analysis of the results of treatment of 342 patients of CEAP 6 with manifestations of chronic vein insufficiency on the background of varicose disease (VD) and post-thrombotic syndrome (PTS) in the surgical clinic of the Transcarpathian Regional Clinical Hospital named after A. Novak (Uzhhorod) for the last 10 years. At least 169 patients had VD (CEAP 6). Post-thrombotic syndrome (occlusive form) was observed in 173 patients (CEAP 6). The ratio of women to men in VD was 3:1, and in PTS was 3:2.
Results. In patients of group I (crossectomy + short stripping + distal scleroobliteration), postoperative complications developed in only 2 (4.3 %) patients in the form of suppuration of the operative wound on the thigh and lymphorrhea. With extended venectomy + SEPS, early postoperative complications were observed in 5 (6 %) patients: three patients had suppuration of the postoperative wound on the thigh, and two patients had lymphorrhea. In classical venectomy + Linton’s operation, inguinal wound suppuration occurred in 2 (5.3 %), lymphorrhea in 3 (7.9 %) patients. Suppuration of the postoperative wound on the lower leg was observed in another 3 (7.9 %) patients. The long-term outcomes in the patients of the group I were: 9 (19.1 %) patients had partial recanalization of the perforated veins of the group of great saphenous vein (GSV) on the lower leg, and one (2.1 %) had complete recanalization. Trophic ulcer (TU) did not heal in one patient after conservative treatment, relapse of TU occurred in 7 (4.1 %) patients. In patients of the group II thrombosis of the cross autovenous shunt (during Palma’s operation) in the early postoperative period was observed in 5 (8.5 %) patients, during autovenous shunting and Husni’s operation (transposition of the GSV into the popliteal vein) in no case. During Linton’s operation, suppuration of the postoperative wound was observed in 7 (15.9 %) cases. TU did not heal with conservative treatment in 5 (56 %) patients.
Conclusions. In the stage of decompensation of VD, pathogenetically justified treatment is crossectomy, venectomy with elimination of horizontal reflux in the zone of trophic ulcer. Trophic ulcers <5 cm and >2 cm deep I–II degrees are treated conservatively after surgery and heal independently within a year. Phlebectomy and CE of the affected limb are contraindicated in PTS. Pathogenetically justified method of treatment is reconstructive and restorative surgery to restore main blood flow with elimination of horizontal reflux in the zone of trophic ulcer.
Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases
Authors: Holovko T. O. , Bohmat L. F. , Shevchenko N. S. , Volkova Yu. V. , Sukhova L. L. , Pavlova O. S.
Published: April 2024

It is known that the dysfunction of the endothelium has crucial role in many pathological conditions and underlines adverse cardiovascular events.
The aim of our study was to determine biologically active substances in the blood that affect endothelial function and homocysteine level in adolescents with rheumatic diseases.
Materials and methods. We examined 68 patients with rheumatic diseases, among them 25 patients with systemic lupus erythematosus (SLE) and 43 patients with juvenile idiopathic arthritis (JIA). Obtained results were compared with similar indicators of peers from the control group. All patients received basic therapy for 12 or more months at the time of examination. Biologically active substances (Homocysteine (Hcy), vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP)) were studied by enzyme-linked immunosorbent assay, brain natriuretic peptide (NT-proBNP) by competitive immunoassay, and angiotensin-converting enzyme (ACE) by turbidimetric FAPGG kinetics method.
Results. Patients with rheumatic diseases had a significantly higher level of BNP (p < 0.01). These changes were most significant in patients with SLE. The level of Hcy did not differ from the similar indicator of the control group, but in patients with SLE it was significantly higher (p < 0.01) than in patients with JIA.
Conclusions. In patients with rheumatic diseases, biologically active substances level affecting the endothelium function depends on the disease. Biologically active substances affecting the function of the endothelium were within normal values. Thus, in children with SLE compared with JIA children, an increase in Hcy and NT-proBNP, and a decrease in ACE and hs-CRP protein were found. In children with JIA, normal levels of Hcy and ACE are accompanied by an increase in NT-proBNP and hs-CRP. In adolescents aged 10–18 years with SLE and JIA, multidirectional changes in biologically active substances and homocysteine, affecting the endothelial function of blood vessels were found.
Diagnosis of acute diverticulitis colon and its purulent – destructive complications
Authors: Mylytsia M. M. , Tymchuk O. B. , Kazakov V. S.
Published: April 2024

Aim. To determine the diagnostic effectiveness of clinical, laboratory and instrumental methods for detecting acute diverticulitis and its perforation complications.
Materials and methods. Retrospective analysis of clinical, laboratory and instrumental diagnostics of 655 patients with a diagnosis of “acute diverticulitis”, and evaluation of its diagnostic accuracy.
Results. Clinical and laboratory diagnosis of acute diverticulitis and its perforated forms allows to suspect this disease as the most likely among other acute inflammatory diseases of the abdomen; at the same time, the sensitivity of these methods for detecting complicated forms does not exceed 51.2 %. Abdominal ultrasound diagnostic has a high sensitivity of 95.3 % and specificity of 99.6 % in the diagnosis of acute diverticulitis and its complications: sensitivity of 88.7 %, specificity of 99.7 %, and could be a leading method verification of this disease. Abdominal CT, which has similar accuracy, could be used as a second-line method in cases of unclear ultrasound data and absence of a free peritonitis clinic.
Conclusions. The sensitivity of clinical methods for detecting complicated forms of acute diverticulitis of the colon does not exceed 51.2 %. The sensitivity of ultrasound diagnosis of acute diverticulitis is 95.3 %, the specificity is 99.6 %, and its complicated forms are 88.7 % and 99.7 %, respectively, which makes this method essential in diagnosis and differential diagnosis. CT according to various indicators should be used as a method of the second line of diagnosis. Ultrasound and CT diagnostics allow monitoring the course of the pathological process and the effectiveness of treatment of acute diverticulitis complicated forms.
Association of preexisting anti-thyroid antibodies and body mass index with prognosis of lung cancer patients treated with PD-1/PD-L1 inhibitors
Authors: Lu Chaoyin , Zhang Dongqing , Chen Lingqiao , Luo Yan , Feng Ping , Gu Xuemei , Wu Wenjun
Published: April 2024

Objectives

Immune checkpoint inhibitors are a new beneficial medication in the treatment of cancer. Whether preexisting TPOAb was related to longer overall survival (OS) is controversial. This retrospective study analyzed the OS and progression-free survival (PFS) of patients with lung cancer, and explored predictive factors associated with the efficacy of PD-1/PD-L1 inhibitors treatment.

Methods

Patients with lung cancer who were hospitalized in the First Affiliated Hospital of Wenzhou Medical University between January 1, 2020 and December 30, 2020 were enrolled. Thyroid function, TPOAb, TGAb, and prognostic nutritional index levels and body mass index were analyzed. Supervising physicians independently assessed patient staging, OS, and PFS. Demographic data, pathological type, and previous treatment history were also collected.

Results

In total, this study enrolled 69 patients, with ages of 46–80 years old. Patients with lower weight showed reduced OS and PFS rates relative to those with normal weight and overweight (p<0.05). The single patient with large cell neuroendocrine carcinoma (LCNEC) exhibited a 1-, 1.5- and 2-year OS rate lower than that of the patients diagnosed with squamous cell carcinoma, small cell lung cancer, or adenocarcinoma (p<0.05). This LCNEC patient also had lower 1-, 1.5-, and 2-year PFS rates compared to adenocarcinoma patients (p<0.05). TPOAb and TGAb levels were unrelated to OS or PFS. Multivariate Cox regression analyses revealed a positive association between body mass index, OS, and PFS.

Conclusions

Patients with lower body weight were predictive of poorer survival outcomes when receiving PD-1/PD-L1 inhibitors treatment as compared to patients with normal weight and overweight. However, positive baseline TGAb and TPOAb levels were not associated with increased OS or PFS in patients with lung cancer.
Factores del comercio social que contribuyen en la decisión de compra del consumidor millennial del estado de Baja California
Authors: Miranda Zavala Ana María , Cruz Estrada Isaac
Published: April 2024

El objetivo de la presente investigación es determinar los factores del comercio social que contribuyen en la decisión de compra del consumidor millennial residente del estado de Baja California, México. Se trata de un estudio transversal, descriptivo y correlacional. Se realizó una revisión de literatura conceptualizando el comercio social (s-commerce). Para el tamaño de la muestra se utilizó una confianza de 97% y un error de 4.2% que corresponde a la representatividad de la población de estudio. Se aplicaron 667 cuestionarios a consumidores millennials, y se realizó un análisis factorial exploratorio. Como resultado se obtuvieron cuatro componentes que contribuyen con la decisión de compra: (1) Atención y seguimiento a las necesidades del cliente durante y posterior a la compra, (2) Proceso de compra segura y eficiente, (3) Estrategias de publicidad y (4) Programas de fidelización. Se concluye que los millennials consideran a las redes sociales una necesidad y tienen una actitud positiva hacia las compras a través del s-commerce y la publicidad, se sienten motivados por los comentarios en las redes sociales, además, toman en cuenta la opinión de otros usuarios antes de realizar la compra.
WYKRESY FAZOWE HYDROLIZATÓW O RÓŻNYM STOPNIU DEPOLIMERYZACJI OTRZYMANYCH NA BAZIE SKROBI MODYFIKOWANYCH CHEMICZNIE
Authors: WITCZAK TERESA , PYCIA KAROLINA , WIKIERA AGNIESZKA , WITCZAK MARIUSZ
Published: April 2024

Background. One of the best ways to present the relationship between phase changes and the stability of food products related to water content and temperature change is a phase diagram. The aim of the pre-sented research was to develop phase diagrams for maltodextrins obtained from native potato starch and acetylated potato starch (E14120) and distarch phosphate (E1412). For this purpose, glass transition curves and freezing curves were determined using the DSC (differential scanning calorimetry) method. As part of the research, an attempt was also made to assess the impact of modification of the original material and the degree of saccharification on the parameters that determine storage stability. Samples with different water activity were obtained by placing dried maltodextrins in an environment with different humidity. The glass transition temperature and freezing temperature were determined using DSC. The results were described using the Gordon and Taylor equation and the Chen equation, and phase diagrams were prepared. Results and conclusions. The glass transition temperature of anhydrous maltodextrins (Tgs) varied in the range of 131.4 ÷ 172.5 ºC depending on the type of modification of base starch and DE. The glass transition temperature (Tg) of all samples decreased with increasing water activity. The obtained values of the k constant of the Gordon-Taylor model ranged from 4.81 to 5.70, and the parameters of the Chen model varied from -0.334 to -0.123 (parameter B) and from 0.074 to 0.117 (parameter E). The values of unfreezable water Xw' (from 0.218 to 0.218 kg of water/kg of sample) and temperature Tm' (from -18.6 to -14.9 °C) and Tg' (from -42.1 to -22.4 °C) determined using a phase diagram for individual maltodextrin samples depended on DE and the type of modification of base starches. The research performed allows us to conclude that native and modified starch hydrolysates were characterized by different thermal proper-ties, which provides wide possibilities of their use in industrial processes.
Solar Power and the Struggle for Electrification in Africa
Authors: Ojong Nathanael
Published: April 2024

Off-grid solar technologies have emerged as one of the remedies to Africa’s severe lack of access to electricity. Evidence from Ghana, Malawi, Tanzania, and Kenya suggests that these systems positively affect income generation, education, health, and safety and security. Despite its potential, off-grid solar power’s technical limitations, combined with concerns about durability and environmental impact, underscore the need for more comprehensive solutions. Addressing Africa’s electrification crisis requires a multifaceted approach involving collaboration among various stakeholders to ensure sustainable, reliable, and inclusive energy access.
Africa in the World Arena
Authors: Grundy Kenneth W.
Published: April 2024

Excerpts from an essay published by Current History in 1967.
Performatividad de género durante el tránsito migratorio en De Nadie (2005) de Tin Dirdamal
Authors: Rodríguez Sonia A.
Published: April 2024

During a time of global massive exodus, I explore the documentary De Nadie (2005) by Tin Dirdamal. Through a variety of narrative instances, this film presents the still very present migrant conditions and the experience of Central American individuals traversing Mexico in their journey to the United States. Considering the exclusion in the past of feminine migrant characters, contemporary cinema and literary narrative present cultural and social meanings that bring to life the presence of women as protagonists in their vertiginous border crossing, under mobility regimes. These narratives provide evidence of women’s identity transcendence beginning with their displacement. In specific, I examine De Nadie (2005) under the lense of gender performativity of the Honduran María, before and during her migratory mobilization.
Exilio, lengua y territorio en Néstor Díaz de Villegas
Authors: Dias Alves de Sousa Pacelli
Published: April 2024

In this article, we analyze the relations between exile, language and territory in a lecture of some selected poems written by Néstor Díaz de Villegas (Cienfuegos, 1956), in his books Vicio de Miami (1997) and Confesiones del estrangulador de Flagler Street (1998). The axis proposed seeks to comprehend, on one hand, some aspects of his poetics, as it was constructed in his first published books and, on the other hand, to analyze his texts in perspective with the Cuban exile condition during the period of the Mariel Crisis (1980), taking into account especially its repercussions in the cultural field.
Stock Price Forecasting using the Machine Learning Based on the Historical Stock Prices
Authors: Vaghela Vimalkumar B. , Champaneria Tushar A. , Rajput Hitesh D.
Published: April 2024

Forecasting stock price is an imperative financial subject matter that has involved researchers’ attention for numerous years. The successful stock price forecasting helps to profit the company or individual otherwise it makes the problem of loss. Stock forecasting involves an assumption that basic information publicly accessible in the past has some predictive relationships to the future stock returns. This proposed research work tries to help the company and investors in the stock market to come to a decision for better timing for buying or selling stocks based on the information extracted from the historical prices of such stocks.
Depression Among Indian Students and Its Association with Perceived TMA Academic Environment, Living Arrangements and Personal Issues
Authors: Rakhmatullaev Elyorbek , Bhat Faizan Shafi
Published: April 2024

The point of the ponder is to discover the level of discouragement among college understudies over sexual orientation, scholarly stream, semesters, recognition of family environment and relationship with guardians, scholarly execution, and family wage. In expansion, the think about analyzes the affiliation between students' seen college scholarly environment, living courses of action, individual issues, and sadness. Seven speculations were defined for confirmation. An add up to of 717 understudies were selected taking after the multistage cluster inspecting strategy, and information were collected by an extraordinarily planned organized survey, scholastic accomplishment record and a standardized College Understudies Misery Stock. Discoveries unveiled that 37.7%, 13.1%, and 2.4% of the understudies were enduring from direct, extreme, and amazingly serious misery. A critical contrast was found over semester, that's, semester II students detailed the next level of misery than semester III understudies. So distant as scholastic stream is concerned, understudies from humanities and social science were found to be enduring from more sadness compared to understudies from science and administration streams. The think about advance unveiled that the understudies who detailed positive sees almost the college scholarly environment and living courses of action had lower level of misery compared to their partners. Individual resilience's such as being able to sharing individual issues with others and doing customary work out were found to be related with positive mental wellbeing. The discoveries of the consider emphasize the require for quick mental wellbeing back administrations for approximately 15.6% of the understudies who were either enduring from serious or greatly extreme sadness at the Tashkent medical academy
Correlation coefficients (R-values) as potential indicators of water quality deterioration for the tropical urban lakes
Authors: Yap Chee Kong , Syazwan Wan Mohd , Nulit Rosimah , Mustafa Muskhazli , Yap Chee Wah , Ismail Mohamad Saupi , Cheng Wan Hee , Kumar Krishnan , Yusuf Mohammed Adana , Ong Meng Chuan , Okamura Hideo , Horie Yoshifumi , Setyawan Ahmad Dwi
Published: April 2024

This study demonstrates the possible application of correlation coefficient (R-values) to reflect the water quality status of tropical urban lakes. Ten water quality parameters were measured from contaminated and unpolluted urban lakes at Kelana Jaya, Malaysia. The correlation analysis on the water quality parameters revealed that the polluted lake had higher numbers of significant correlation coefficients with highly significant levels of P< 0.001, attributable to the broader ranges of water quality metrics acquired from the former. This work provides baseline evidence for the potential use of R-values as prospective markers of water quality degradation in tropical urban lakes.
Segmental thoracic anesthesia for transabdominal colectomy with spontaneous ventilation through combined spinal-epidural block. Case report with video
Authors: Imbelloni, MD, PhD Luiz Eduardo , Fornasari, MD Marcos , Sant’Anna, MD Raphael , Fialho, MD José Carlos , Rivoli, MD Anna Lúcia Calaça , Neto, MD, PhD Sylvio Valença de Lemos
Published: April 2024

Introduction: The combined spinal-epidural (CSE) technique offers advantages over the epidural or single injection spinal anesthesia alone. Assessing the distance between the dura mater and the spinal cord in the thoracic region with magnetic resonance imaging showed that there is a large space that allows the needle to enter without reaching the spinal cord. Segmental thoracic spinal anesthesia is being used in several types of surgery. Case report: A woman aged 73 years, 64 kg, 163 cm, physical status ASA II, type II diabetic, with systemic arterial hypertension, was scheduled for resection of a tumor in the right colon. The CSE was placed at the T9-T10 interspace and 10mg 0.5% hyperbaric bupivacaine was injected into the subarachnoid space. The epidural catheter (20G) was then inserted four centimeters. Sedation was obtained with 1mg of midazolam as needed (total 5mg). Two hours after 0.5% bupivacaine had to be administered in a bolus of 25 mg through the catheter. There was no necessity for the use of vasopressor drugs or atropine. Conclusion: This case has provided evidence that segmental spinal anesthesia can be an effective anesthetic technique for gastrointestinal surgery with spontaneous ventilation, and the infusion of 0.1% bupivacaine with an elastomeric pump provided 40 hours of analgesia.
Detection of epileptiform discharges by patient state index and density spectral array during anesthetic emergence after resection of hemispheric brain tumor. Case report
Authors: Arzate Ana Ilayali Moreno , Corona Alejandro Obregon
Published: April 2024

Background: Processed electroencephalogram (EEGp) plays a crucial role in anesthesia as a quantitative and automated method for assessing anesthetic depth. It utilizes mathematical algorithms to furnish objective measures, offering an intuitive interface for anesthesiologists lacking specialized neurophysiology training. Among the array of visual graphical analyses, the Density Spectral Array (DSA) stands out as particularly promising. DSA furnishes a comprehensive and visual depiction of the patient's brain activity, aiding anesthesiologists in maintaining optimal anesthetic depth during surgical procedures Conclusion: This report underscores the potential of analyzing Case report: A 51-year-old male with a medical history of neurofibromatosis type 2 and a frontal hemispheric brain tumor underwent resection in the operating room under total intravenous anesthesia. Anesthetic depth was monitored utilizing SedLine® Patient Status Index (PSi). The resection proceeded uneventfully; however, upon extubation, EEG processing revealed epileptiform discharges concurrent with tonic-clonic movement of the right hand electroencephalogram waveforms alongside the latest SedLine-derived Density Spectral Array to confirm the presence of partial epileptic seizures during the immediate post-extubation and postoperative phases following brain tumor resection. Employing advanced monitoring techniques like Density Spectral Array aids in early detection of neurological complications, facilitating timely intervention and potentially enhancing patient outcomes during the critical postoperative period.
Quantum chaos of the BKL scenario
Authors: Piechocki Włodzimierz
Published: April 2024

The Belinski-Khalatnikov-Lifshitz (BKL) scenario concerns the existence of generic singularity of general relativity. Evolving towards that singularity, spacetime enters a chaotic phase. We consider a model of the BKL scenario to get insight into the corresponding quantum dynamics. The integral quantization of the BKL model leads to quantum evolution devoid of singularity. The quantum fluctuations seem to be unable to suppress the classical chaos. These interesting features of quantum dynamics result from the never vanishing variance of considered quantum dynamics. We suggest that these results generalize to a quantum model (to be constructed) of the original BKL scenario.
Coding Review: Amount and/or Complexity of Data
Authors:   American Academy of Pediatrics
Published: April 2024

This article reviews the amount and/or complexity of data to be reviewed and analyzed as an element of medical decisionmaking (MDM) performed during an evaluation and management (E/M) service. This includes the following:

Review of results of tests ordered at a prior visit Order for and independent interpretation of tests Documents from a unique entity Discussions about management or test interpretation
Connecting Coding and Clinical Practice Guidelines: Obesity
Authors:   American Academy of Pediatrics
Published: April 2024

This article reviews coding for obesity-related services, including appropriate diagnosis and procedure codes for the following services:

Preventive screening services Preventive counseling services Evaluation and management (E/M) services to treat obesity Behavioral health services Pediatric bariatric surgery
Coding Visits to Treat Overweight and Obesity
Authors:   American Academy of Pediatrics
Published: April 2024

This article reviews examples of office and other outpatient evaluation and management (E/M) services for treatment of overweight and obesity, including the following.:

Time-based code selection Code selection based on medical decision-making (MDM)
Biomass and bioethanol production of the shrub Ulex europaeus (Fabaceae) estimated with remote sensor imagery in the Andean paramos
Authors: Osorio-Castiblanco Diego F.
Published: April 2024

Introduction: Gorse (Ulex europaeus, family Fabaceae) is an evergreen shrub native to Europe and invasive in the Andean high-mountain tropical paramos. Objective: To quantify the extent of a biological invasion within a paramo near Los Nevados National Natural Park in Tolima, Colombia, and evaluate bioeconomic solutions to encourage shrub eradication while promoting the local economy and industry. Methods: An object-based supervised classification approach was conducted using UAS (Uncrewed Aircraft Systems)-based RGB imagery and a Planet-derived NDVI (Normalized Difference Vegetation Index) layer, both from 2022, to quantify the area invaded. This value, the height obtained from a UAS-derived nDSM (Normalized Digital Surface Model), and a pair of allometric equations found in the literature were employed to estimate the gorse aboveground biomass (AGB) and aboveground available fuel, also known as fuel load. Then, documented bioethanol production estimations were applied to calculate its potential extraction based on the AGB values. Results: The invaded area was quantified to be 66 465 m2, with an overall accuracy rate of 85.3 %. Furthermore, the fuel load was found to be approximately half of the AGB, which poses a high risk of fire in the ecosystem. The findings also suggest that up to USD 88 933.7 could be generated if all gorse in the study area is exploited to produce bioethanol. Conclusions: This study underscores the urgency of managing the biological invasion of gorse in the Andean paramo and suggests the potential for bioeconomic solutions to mitigate the impact of these invasions.
Digestive proteases of Morelet’s crocodile (Crocodylus moreletii) in three life stages
Authors: Castillo-Rodríguez Manuel Alejandro , Rangel-Mendoza Judith Andrea , Peña-Marín Emyr Saúl , Álvarez-González Carlos Alfonso , López-Luna Marco Antonio , Maytorena-Verdugo Claudia Ivette
Published: April 2024

Introduction: Morelet’s crocodile (Crocodylus moreletii) is a species distributed in the Mexican southeast and threatened due to multiple pressures. Objective: To characterize the digestive proteases in the acid phase (stomach) and alkaline phase (intestine) of three life stages of C. moreletii in captivity (hatchling, juvenile, and adult). Methods: Total alkaline and acid protease activities were quantified using casein and haemoglobin as substrates. Trypsin, chymotrypsin, leucine aminopeptidase, and elastase activities were quantified using synthetic substrates. Protease profiles were analysed by SDS-PAGE and Native-PAGE. Results: The specific activity of acid and alkaline proteases showed differences between the three stages, finding the highest activity in the juveniles. Trypsin, chymotrypsin, leucine aminopeptidase, and elastase activities were higher in hatchlings. There were differences in optimum pH and temperature of acid and alkaline proteases, trypsin, and leucine aminopeptidase between the three stages, demonstrating the diversification of the enzymes according to different stages, as well as the presence of specific isoforms in each stage of C. moreletii. The acid phase zymogram showed four bands with pepsin-like acid activity in the hatchling and juvenile crocodile, while in the adult only two of the four bands were detected. The alkaline zymogram showed that the hatchling had the highest number of activity bands compared to the other stages, corresponding to the high specific activity reported in the alkaline phase. Conclusions: Digestive proteases of Morelet’s crocodile differ in their biochemical characteristics and the number of proteases between hatchling, juvenile, and adult. This could help in the future design of balanced diets as well to the sustainable management and production of this species.
First records of the families Metapelmatidae and Neanastatidae (Hymenoptera, Chalcidoidea) in Saudi Arabia
Authors: Usman Syeda Uzma , Khan Farmanur Rahman , Ahmad Syed Kamran , Alhewairini Saleh Sulaiman , Anwar Prince Tarique
Published: April 2024

The families Metapelmatidae and Neanastatidae (Hymenoptera, Chalcidoidea) are recorded for the first time from Saudi Arabia based on the presence of Metapelma mirabile Brues, 1906 and Neanastatus africanus Ferrière, 1938, respectively.
Análisis fitoquímico de compuestos de interés terapéutico del muérdago Psittacanthus Calyculatus ubicado en el cerro del Palenque de Purísima del Rincón, Guanajuato
Authors: Flores Sierra José de Jesús , Sánchez Guevara Daniela , Xoca Orozco Luis Ángel , Hernández Mendoza Gustavo , Reyes Bautista Raúl
Published: April 2024

Psittacanthus calyculatus es una plaga significativa en México distribuida en el centro y sur causando pérdidas económicas. Para encontrarle un valor agregado se realizó un perfil fitoquímico para identificar compuestos con actividad terapéutica. Se realizaron dos métodos de extracción: metanol/acetona/agua y acuoso. La identificación fitoquímica fue mediante el uso de reactivos que causaban cambio en la coloración, evidenciándose fenoles, flavonoides, alcaloides, entre otros. Los fenoles se cuantificaron por Folin-Ciocalteu, encontrándose mayor concentración (p< 0.03) en extracción acuoso de flor (EAF) (32.84 ± 1.2 mg EAG/ml) que en extracción metanol/acetona/agua de flor (EMAAF), hoja extracción metanol/acetona/agua (EMAAH) y extracción acuosa de hoja (EAH) (13.71 ± 1, 20.1± 0.3, 12.39 ± 0.4 mg EAG/ml, respectivamente). Los flavonoides se cuantificaron por colorimetría,  encontrándose más concentración en EAF (49.8 ± 2 mg EC/ ml) (p≤0.02) con respecto a EMAAF, EMAAH y EAH (9.5 ±1, 20.4 ± 0.5 y 10.3 ± 5 mg EC/ ml, respectivamente). La actividad antioxidante fue medida por DPPH, todos los extractos mostraron actividad antioxidante, de acuerdo con el valor IC50 para EMAAF y EMAAH fueron 0.058 y 0.0035 mg/ml (p<0.03) respectivamente, para EAF y EAH fueron 0.15 y 0.08 mg/ml (p<0.03) respectivamente. Estos resultados sugieren que Psittacanthus calyculatus posee una importante actividad antioxidante, esto puede deberse al contenido de fitoquímicos, lo cual se sugiere que esta planta puede ser una importante fuente de nutrientes naturales, con actividad quimioterapéutica.
The Effects of Different Breathing Techniques on Lower Extremity Muscle Function and Postural Stability
Authors: Baek Gwangyeol , Shin Yun-A , Lee Kun-Ho
Published: April 2024

OBJECTIVES This study examines the effects of bracing versus hollowing breathing techniques on lower limb muscle function and postural stability, aiming to identify the most effective breathing strategy for functional movement.METHODS Conducted on ten healthy males in their twenties without back or musculoskeletal issues, the study involved pre-experiment training in both breathing techniques. It assessed maximal strength, endurance, and power during knee flexion and extension, alongside postural stability, with both eyes open and closed, using the non-parametric Wilcoxon signed-rank test for analysis.RESULTS Except for certain specific measurements (right flexor muscle peak torque, left flexor muscle total work, and right extensor muscle power), statistical analysis showed significant differences in Knee muscle function favoring the bracing technique (p<.05). While postural stability tests showed no significant overall differences between the techniques, an observable trend emerged: the hollowing group showed superior performance in one-foot balance tasks, whereas the bracing group demonstrated better outcomes in two-footed stances.CONCLUSIONS It is anticipated that bracing breathing will positively influence muscle training, surpassing the effects of hollowing by bolstering the strength, endurance, and power of the lower limbs. However, for postural stability, the hollowing technique may offer advantages in tasks requiring higher balance acuity, like one-legged standing. In contrast, bracing appears more effective for simpler stability tasks. These findings underscore breathing techniques' role in physical performance, highlighting the need for further, detailed research considering posture and musculoskeletal influences.
Curly lettuce production using cassava wastewater as a potassium source
Authors: Torres Jose Luiz R. , Vieira Dinamar M. da S. , Barreto Antônio C. , Charlo Hamilton C. de O. , Loss Arcangelo , Thuler Robson T. , Camargo Reginaldo de , Lemes Ernane M.
Published: April 2024

ABSTRACT Cassava wastewater (CWW) is a natural biofertilizer successfully tested as a source of K in long-cycle crops; however, it still needs to be better evaluated in short-cycle crops. This study aimed to evaluate the use of CWW as a source of K in the growth, yield, and physicochemical quality of curly lettuce. The study was conducted in a greenhouse, in a randomized block design arranged in a 5 × 2 + 1 factorial scheme, with four replicates. Five CWW doses were evaluated as an exclusive source of K: 0, 60, 120, 180, and 240 kg ha-1 of K2O; two forms of application: 1-total dose at planting: 2-application of 50% of the dose at planting + 50% of the dose in topdressing, and an additional treatment: 100% mineral fertilization at 120 kg ha-1 of K2O dose, using KCl as the source. The number of leaves (NL), plant height (PH), fresh mass (FM), dry mass (DM), moisture (MO), ashes (ASH), fibers (FB), lipids (LIP), proteins (PTN), and carbohydrates (CHO) contents were evaluated. All agronomic attributes of lettuce showed lower values when fertilized only with CWW than mineral fertilization. Lettuce fertilized only with CWW, depending on total or split application and dose, showed higher ASH, FB, LIP, PTN, and CHO contents reaching 4.05, 3.97, 1.75, 7.11, and 3.63%, respectively, compared to mineral fertilization. The CWW can potentially be used as a complementary K source in lettuce cultivation, as its exclusive use does not replace traditional mineral fertilization.
EFETIVIDADE DE TECNOLOGIA EDUCACIONAL EM FORMATO DE VÍDEO SOBRE BANHO DOMICILIAR DO RECÉM-NASCIDO A TERMO
Authors: Corrêa Bianca da Silva Ornellas , Góes Fernanda Garcia Bezerra , Silva Aline Cerqueira Santos Santana da , Silva Maria da Anunciação , Goulart Maithê de Carvalho e Lemos , Campos Brenda Lucas , Silva Liliane Faria da
Published: April 2024

RESUMO Objetivo: avaliar a efetividade de uma tecnologia educacional em formato de vídeo no conhecimento de familiares cuidadores sobre banho domiciliar do recém-nascido a termo. Método: estudo quantitativo com delineamento quase-experimental, de grupo único, do tipo antes e depois, realizado entre fevereiro e junho de 2023, no Alojamento Conjunto de um hospital municipal da baixada litorânea do Estado do Rio de Janeiro. A coleta de dados foi composta por três etapas (pré-teste, intervenção e pós-teste) e utilizou-se para análise o teste de McNemar para comparar a proporção de acertos antes e após a intervenção. Adotou-se p<0,05. Resultados: participaram 107 familiares, sendo 86 mulheres (80,4%). Verificou-se aumento de 36,5% no total de respostas corretas no pós-teste após o uso da tecnologia educacional. A maioria das questões apresentou aumento no número de acertos (n=16; 88,9%), sendo mais da metade com diferença estaticamente significativa entre o pré-teste e o pós-teste. Destacaram-se as questões sobre utilização de marcas variadas de produtos de higiene, uso de talco, cuidados com o coto umbilical e o tipo de banho mais indicado, bem como temperatura e duração do banho. Conclusão: o vídeo educativo “Como dar o banho do recém-nascido em casa” se mostrou efetivo no aumento do conhecimento sobre o banho domiciliar do recém-nascido a termo. Assim, pode-se utilizar o vídeo avaliado sobre o tema como uma tecnologia educacional em saúde com as famílias, a fim de promover um cuidado mais seguro ao recém-nascido.