bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards Profit Optimization During Online Participant Selection in Compressive Mobile Crowdsensing
Authors: Chen Yueyue , Guo Deke , Bhuiyan MD Zakirul Alam , Xu Ming , Wang Guojun , Lv Pin
Published: August 2019

A mobile crowdsensing (MCS) platform motivates employing participants from the crowd to complete sensing tasks. A crucial problem is to maximize the profit of the platform, i.e., the charge of a sensing task minus the payments to participants that execute the task. In this article, we improve the profit via the data reconstruction method, which brings new challenges, because it is hard to predict the reconstruction quality due to the dynamic features and mobility of participants. In particular, two Profit-driven Online Participant Selection (POPS) problems under different situations are studied in our work: (1) for S-POPS, the sensing cost of the different parts within the target area is the Same. Two mechanisms are designed to tackle this problem, including the ProSC and ProSC+. An exponential-based quality estimation method and a repetitive cross-validation algorithm are combined in the former mechanism, and the spatial distribution of selected participants are further discussed in the latter mechanism; (2) for V-POPS, the sensing cost of different parts within the target area is Various, which makes it the NP-hard problem. A heuristic mechanism called ProSCx is proposed to solve this problem, where the searching space is narrowed and both the participant quantity and distribution are optimized in each slot. Finally, we conduct comprehensive evaluations based on the real-world datasets. The experimental results demonstrate that our proposed mechanisms are more effective and efficient than baselines, selecting the participants with a larger profit for the platform.
The open PCA pump project
Authors: Hatcliff John , Larson Brian , Carpenter Todd , Jones Paul , Zhang Yi , Jorgens Joseph
Published: August 2019

Building safe and secure interoperable medical devices with accompanying assurance artifacts is challenging. Many start-up companies have great ideas for innovation, but are not familiar with appropriate safety/security-critical engineering processes, architecture principles, risk management, and assurance techniques. Larger, more experienced, companies may face hurdles in re-engineering their devices for interoperability and greater security. In academia, researchers often have good techniques for addressing some of the issues above, but are not familiar with how a realistic medical device is developed and assured. Building a prototype medical device for a classroom project or research work to validate proposed techniques is often a huge effort.

The Open PCA Pump illustrates a full suite of realistic development artifacts including use cases, requirements, architecture models, verified source code, testing and simulation infrastructure, risk management artifacts, and assurance cases that can be used to develop shared understanding of medical device innovations across the academic, industry, and regulatory communities.1
A use error taxonomy for improving human-machine interface design in medical devices
Authors: Silva Carlos , Masci Paolo , Zhang Yi , Jones Paul , Campos José C.
Published: August 2019

Use error is one of the leading causes of medical device incidents. It is crucial for all stakeholders to have a unified means to better understand, classify, communicate, and prevent/avoid medical device use errors. In this paper, we present our ongoing work on developing a new use error taxonomy for medical devices that has the potential to enable fine-grained analysis of use errors and their root causes in system design. Our ultimate goal is to create a generic framework that can be used by medical device designers to better identify effective design solutions to mitigating use errors.
The benefits of using interactive device simulations as training material for clinicians
Authors: Bernardeschi Cinzia , Masci Paolo , Caramella Davide , Dell'Osso Ruggero
Published: August 2019

This paper reports on our experience in developing training material for a hospital, in the form of an interactive simulation of a medical device routinely used in the hospital. The subject device is a commercial contrast media injector used in Computed Tomography (CT) scans. The specification of the device was reverse engineered using in combination the user manual, direct interaction with the real device, and the results of a field study we conducted that focused on how expert users routinely operate the device. The interactive simulation greatly helped to identify critical workflows that could induce accidental use errors that lead to dangerous situations such as failure to correctly detect air-in-line before starting the injection. The interactive simulation proved also useful to stimulate a constructive discussion within a multidisciplinary team of engineers and clinicians, about possible design improvements to the device that could prevent the identified critical workflows.
RePulmo
Authors: Nguyen Hung , Ivanov Radoslav , DeMauro Sara B. , Weimer James
Published: August 2019

Remote physiological monitoring is increasing in popularity with the evolution of technologies in the healthcare industry. However, the current solutions for remote monitoring of blood-oxygen saturation, one of the most common continuously monitored vital signs, either have inconsistent accuracy or are not secure for transmitting over the network. In this paper, we propose RePulmo, an open-source platform for secure and accurate remote pulmonary data monitoring. RePulmo satisfies both robustness and security requirements by utilizing hospital-grade pulse oximeter devices with multiple layers of security enforcement. We describe two applications of RePulmo, namely (1) a remote pulmonary monitoring system for infants to support the Children's Hospital of Philadelphia (CHOP) clinical trial; (2) a proof-of-concept of a low SpO2 smart alarm system.
CognitiveEMS
Authors: Preum Sarah , Shu Sile , Hotaki Mustafa , Williams Ronald , Stankovic John , Alemzadeh Homa
Published: August 2019

This paper presents our preliminary results on development of a Cognitive assistant system for
Emergency Medical Services (CognitiveEMS)
that aims to improve situational awareness and safety of first responders.
CognitiveEMS
integrates a suite of smart wearable sensors, devices, and analytics for real-time collection and analysis of in-situ data from incident scene and delivering dynamic data-driven insights to responders on the most effective response actions to take. We present the overall architecture of
CognitiveEMS
pipeline for processing information collected from the responder, which includes stages for converting speech to text, extracting medical and EMS protocol specific concepts, and modeling and execution of an EMS protocol. The performance of the pipeline is evaluated in both noise-free and noisy incident environments. The experiments are conducted using two types of publicly-available real EMS data: short radio calls and post-incident patient care reports. Three different noise profiles are considered for simulating the noisy environments: cafeteria, people talking, and emergency sirens. Noise was artificially added at 3 intensity levels of low, medium, and high to pre-recorded audio data. The results show that the i) state-of-the-art speech recognition tools such as Google Speech API are quite robust to low and medium noise intensities; ii) in the presence of high noise levels, the overall recall rate in medical concept annotation is reduced; and iii) the effect of noise often propagates to the final decision making stage and results in generating misleading feedback to responders.
Cardiac intramural electrical mapping reveals focal delays but no conduction velocity slowing in the peri-infarct region
Authors: Trew Mark L. , Engelman Zoar J. , Caldwell Bryan J. , Lever Nigel A. , LeGrice Ian J. , Smaill Bruce H.
Published: August 2019

Altered electrical behavior alongside healed myocardial infarcts (MIs) is associated with increased risk of sudden cardiac death. However, the multidimensional mechanisms are poorly understood and described. This study characterizes, for the first time, the intramural spread of electrical activation in the peri-infarct region of chronic reperfusion MIs. Four sheep were studied 13 wk after antero-apical reperfusion infarction. Extracellular potentials (ECPs) were recorded in a ~20 × 20-mm2 region adjacent to the infarct boundary (25 plunge needles <0.5-mm diameter with 15 electrodes at 1-mm centers) during multisite stimulation. Infarct geometry and electrode locations were reconstructed from magnetic resonance images. Three-dimensional activation spread was characterized by local activation times and interpolated ECP fields ( n = 191 records). Control data were acquired in 4 non-infarcted sheep ( n = 96 records). Electrodes were distributed uniformly around 15 ± 5% of the intramural infarct boundary. There were marked changes in pacing success and ECP morphology across a functional border zone (BZ) ±2 mm from the boundary. Stimulation adjacent to the infarct boundary was associated with low-amplitude electrical activity within the BZ and delayed activation of surrounding myocardium. Bulk tissue depolarization occurred 3.5–14.6 mm from the pacing site for 39% of stimuli with delays of 4–37 ms, both significantly greater than control ( P < 0.0001). Conduction velocity (CV) adjacent to the infarct was not reduced compared with control, consistent with structure-only computer model results. Insignificant CV slowing, irregular stimulus-site specific activation delays, and obvious indirect activation pathways strongly suggest that the substrate for conduction abnormalities in chronic MI is predominantly structural in nature.

NEW & NOTEWORTHY Intramural in vivo measurements of peri-infarct electrical activity were not available before this study. We use pace-mapping in a three-dimensional electrode array to show that a subset of stimuli in the peri-infarct region initiates coordinated myocardial activation some distance from the stimulus site with substantial associated time delays. This is site dependent and heterogeneous and occurs for <50% of ectopic stimuli in the border zone. Furthermore, once coordinated activation is initiated, conduction velocity adjacent to the infarct boundary is not significantly different from control. These results give new insights to peri-infarct electrical activity and do not support the widespread view of uniform electrical remodeling in the border zone of chronic myocardial infarcts, with depressed conduction velocity throughout.
Exosomes derived from induced vascular progenitor cells promote angiogenesis in vitro and in an in vivo rat hindlimb ischemia model
Authors: Johnson Takerra K. , Zhao Lina , Zhu Dihan , Wang Yang , Xiao Yan , Oguljahan Babayewa , Zhao Xueying , Kirlin Ward G. , Yin Liya , Chilian William M. , Liu Dong
Published: August 2019

Induced vascular progenitor cells (iVPCs) were created as an ideal cell type for regenerative medicine and have been reported to positively promote collateral blood flow and improve cardiac function in a rat model of myocardial ischemia. Exosomes have emerged as a novel biomedicine that mimics the function of the donor cells. We investigated the angiogenic activity of exosomes from iPVCs (iVPC-Exo) as a cell-free therapeutic approach for ischemia. Exosomes from iVPCs and rat aortic endothelial cells (RAECs) were isolated using a combination of ultrafiltration and size-exclusion chromatography. Nanoparticle tracking analysis revealed that exosome isolates fell within the exosomal diameter (<150 nm). These exosomes contained known markers Alix and TSG101, and their morphology was validated using transmission electron microscopy. When compared with RAECs, iVPCs significantly increased the secretion of exosomes. Cardiac microvascular endothelial cells and aortic ring explants were pretreated with RAEC-Exo or iVPC-Exo, and basal medium was used as a control. iVPC-Exo exerted an in vitro angiogenic effect on the proliferation, tube formation, and migration of endothelial cells and stimulated microvessel sprouting in an ex vivo aortic ring assay. Additionally, iVPC-Exo increased blood perfusion in a hindlimb ischemia model. Proangiogenic proteins (pentraxin-3 and insulin-like growth factor-binding protein-3) and microRNAs (-143-3p, -291b, and -20b-5p) were found to be enriched in iVPC-Exo, which may mediate iVPC-Exo induced vascular growth. Our findings demonstrate that treatment with iVPC-Exo promotes angiogenesis in vitro, ex vivo, and in vivo. Collectively, these findings indicate a novel cell-free approach for therapeutic angiogenesis.

NEW & NOTEWORTHY The results of this work demonstrate exosomes as a novel physiological mechanism by which induced vascular progenitor cells exert their angiogenic effect. Moreover, angiogenic cargo of proteins and microRNAs may define the biological contributors in activating endothelial cells to form a new capillary plexus for ischemic vascular diseases.

Listen to this article's corresponding podcast at https://ajpheart.podbean.com/e/angiogenic-exosomes-from-vascular-progenitor-cells/ .
Evaluating the Utility and Prevalence of HPV Biomarkers in Oral Rinses and Serology for HPV-related Oropharyngeal Cancer
Authors: D'Souza Gypsyamber , Clemens Gwendolyn , Troy Tanya , Castillo Rachel G. , Struijk Linda , Waterboer Tim , Bender Noemi , Pierorazio Phillip M. , Best Simon R. , Strickler Howard , Wiley Dorothy J. , Haddad Robert I. , Posner Marshall , Fakhry Carole
Published: August 2019

Performance of commercially available human papillomavirus (HPV) assays (approved for cervical HPV detection) is unknown for detecting HPV-related oropharyngeal cancer (HPV-OPC). Assays for detection of HPV DNA [ELISA (DEIA) and Cobas], and RNA (Aptima) in oral rinse samples, and serum HPV oncogene antibodies were evaluated. Sensitivity and specificity of each test was explored among HPV-OPC cases and controls. Biomarker prevalence was evaluated among 294 “at-risk” people (screening) and 133 “high-risk” people [known to previously have oral oncogenic HPV (oncHPV) DNA and/or HPV16 E6/E7 antibodies detected]. HPV16 E6 antibodies had the best overall test performance with sensitivity of 88%, compared with oral HPV16 DNA sensitivity of 51% by DEIA and 43% by Cobas (each P < 0.001). Specificity was comparable in each of these tests (≥98%). When positivity for any oncHPV type was compared with HPV16 for the same test, sensitivity was comparable (60% vs. 51%, 40% vs. 43%, and 92% vs. 88% for DEIA, Cobas, and E6 antibodies, respectively), but specificity was reduced (93%–97%). Aptima had poor sensitivity (23%). Sensitivity decreased when cotesting HPV16 oral rinse DNA and E6 antibodies (37%–48%), or multiple E antibodies (69%–72%). HPV16 DNA were detected in ∼2% of the at-risk by either DEIA or Cobas and up to 15% of the high-risk population. HPV16 E6 seroprevalence was 2.3% and 2.4% in the at-risk and high-risk populations, respectively. Oral rinse HPV testing had moderate-to-poor sensitivity for HPV-OPC, suggesting many true positives would be missed in a potential screening scenario. HPV16 E6 serum antibody was the most promising biomarker evaluated.
Effect of Gonadotrophin-Releasing Hormone Agonist Addition for Luteal Support on Pregnancy Outcome in vitro Fertilization/Intracytoplasmic Sperm Injection Cycles: A Meta-Analysis Based on Randomized Controlled Trials
Authors: Ma Xiaoling , Du Wenjing , Hu Junping , Yang Yuan , Zhang Xuehong
Published: August 2019

Purpose: The meta-analysis aimed to evaluate the effect of gonadotrophin-releasing hormone agonist (GnRH-a) addition for luteal support on pregnancy outcome in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles. Methods: Meta-analysis. Results: A total of 3,584 cycles were identified from 13 randomized controlled trials. The cumulative analysis showed that GnRH-a addition for luteal supports significantly improved live birth rate (relative risk [RR] = 1.52; 95% CI 1.20–1.94; p = 0.0006), the clinical pregnancy rate (RR 1.21; 95% CI 1.11–1.33; p < 0.0001), ongoing pregnancy rate (RR 1.18; 95% CI 1.06–1.32; p = 0.004), pregnancy rate (RR 1.36; 95% CI 1.01–1.82; p = 0.04), implantation rate (RR 1.44; 95% CI 1.17–1.77; p = 0.0007), and multiple pregnancy rate (RR 1.40; 95% CI 1.04–1.88; p = 0.03) in comparison with control, but not for the incidence of ovarian hyperstimulation syndrome (RR 0.96; 95% CI 0.32–2.89; p = 0.94). We also found that GnRH-a addition for luteal support had a tendency to decrease the abortion rate (RR 0.72; 95% CI 0.56–0.93; p = 0.01). Conclusions: Overall, the current meta-analysis showed a substantial efficacy of GnRH-a addition for luteal support on pregnancy outcomes in women undergoing IVF/ICSI and support the use of GnRH-a in luteal phase to improve the success of IVF/ICSI.
The Long-Term Risk of Dementia after Transient Global Amnesia: A Population-Based Cohort Study in Taiwan
Authors: Hsieh Sun-Wung , Chen Chun-Hung , Huang Poyin , Li Chien-Hsun , Yang Shan-Tzu , Yang Yuan-Han
Published: August 2019

Background: Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of larger anterograde and milder retrograde amnesia that lasts up to 24 h. Objectives: We aimed to investigate the long-term risk of dementia up to 8 years in subjects with TGA. Method: We conducted a control cohort study using the Taiwan National Health Insurance Research database from 2005 to 2012 with an 8-year follow-up period. From all potential participants >18 years of age without dementia history, we identified TGA subjects and non-TGA controls with age, gender and comorbidities matched in a 1:3 ratio. The yearly incidence of dementia was compared in TGA and non-TGA cohorts. The cumulative hazard ratio (HR) of dementia was estimated. The risk factors of dementia after TGA were investigated. Results: A total of 181 TGA subjects and 543 non-TGA controls were included in the study. There were 14 dementia cases in the 181 TGA cohorts during the follow-up period with yearly incidence rates of 20.14 per 1,000 person. The adjusted HR for dementia in TGA cohorts was 2.23 (95% CI 1.12–4.44, p = 0.023) compared with non-TGA cohorts after adjusting for age, gender and comorbidities. Age and diabetes were significantly associated with dementia in TGA. Conclusions: TGA increased the long-term risk of dementia. Age and diabetes were notable factors associated with dementia after TGA.
Traditional and Digital Biomarkers: Two Worlds Apart?
Authors: Babrak Lmar M. , Menetski Joseph , Rebhan Michael , Nisato Giovanni , Zinggeler Marc , Brasier Noé , Baerenfaller Katja , Brenzikofer Thomas , Baltzer Laurenz , Vogler Christian , Gschwind Leo , Schneider Cornelia , Streiff Fabian , Groenen Peter M.A. , Miho Enkelejda
Published: August 2019

The identification and application of biomarkers in the clinical and medical fields has an enormous impact on society. The increase of digital devices and the rise in popularity of health-related mobile apps has produced a new trove of biomarkers in large, diverse, and complex data. However, the unclear definition of digital biomarkers, population groups, and their intersection with traditional biomarkers hinders their discovery and validation. We have identified current issues in the field of digital biomarkers and put forth suggestions to address them during the DayOne Workshop with participants from academia and industry. We have found similarities and differences between traditional and digital biomarkers in order to synchronize semantics, define unique features, review current regulatory procedures, and describe novel applications that enable precision medicine.
Comparison of Two Different Fibrinogen Concentrates in an in vitro Model of Dilutional Coagulopathy
Authors: Groene Philipp , Wiederkehr Tobias , Kammerer Tobias , Möhnle Patrick , Maerte Melanie , Bayer Andreas , Görlinger Klaus , Rehm Markus , Schäfer Simon T.
Published: August 2019

Introduction: Fibrinogen concentrates are widely used to restore clot stability in situations of bleeding. Fibrinogen preparations are produced using different production methods, resulting in different compounds. Thus, different preparations might have a distinct impact on blood coagulation. We tested the effect of fibrinogen concentrates Haemocomplettan® (CSL Behring, Marburg, Germany) and fibryga® (Octapharma GmbH, Langenfeld, Germany) on the impairments induced by 60% dilutional coagulopathy in vitro. Materials and Methods: The influence of the fibrinogen concentrates fibryga® and Haemocomplettan® on colloid (gelatine, hydroxyethyl starch [HES], albumin)-induced or crystalloid (Ringer’s acetate)-induced dilutional coagulopathy was analysed using rotational thromboelastometry (ROTEM®) and standard laboratory tests. The following experimental conditions were analysed in vitro: whole blood, 60% dilution (40% blood and 60% diluent) ± 50 or 100 mg/kg–1 fibryga® or Haemocomplettan®, respectively. Results: Dilution with either diluent resulted in prolonged clotting time (CT) in an extrinsic activated test (CTEXTEM) and decreased maximum clot firmness (MCFFIBTEM) as expressed, e.g., by gelatine: (59.5 s [62/54.8] vs. 95 s [102.8/86.8]; p < 0.001 and 14 mm [16/10.5] vs. 3 mm [4–3]; p < 0.001). Substitution after 60% dilution with HES resulted in no difference between the preparations, except for shorter thrombin time with fibryga® (14 s [15/14] vs. 18 s [18.8/17]; p = 0.0093; low dose). CTEXTEM was higher with Haemocomplettan® in a gelatine-induced dilution (51 s [54.5/47.5] vs. 63 s [71/60.3]; p = 0.0202; low dose) whereas thrombin time was lower with fibryga® (19.5 s [20.8/19] vs. 27 s [29/25.3]; p = 0.0017). In dilution with albumin, differences in CTEXTEM (69 s [76.5/66] vs. 56 s [57/53.3]; p = 0.0114; low dose) and thrombin time (18 s [18/17] vs. 24.5 s [25.8/24]; p = 0.0202; low dose) were seen. In dilution with crystalloid solution, again differences in CTEXTEM (53.5 s [57.8/53] vs. 45 s [47/43]; p = 0.035; low dose) and thrombin time (17 s [17/16] vs. 23.5 s [24/23]; p = 0.0014; low dose) were seen. Fibrinogen levels were more increased by high-dose substitution of both preparations. Conclusion: Based on this data it can be stated that both fibryga® and Haemocomplettan® had the same performance in our in vitro model except for CTEXTEM and thrombin time.
Incidence of Morphea following Adjuvant Irradiation of the Breast in 2,268 Patients
Authors: Partl Richard , Regitnig Peter , Lukasiak Katarzyna , Winkler Peter , Kapp Karin Sigrid
Published: August 2019

Background: Morphea of the breast is an autoimmune reaction of the subcutaneous connective tissue which can be triggered by exposure to ionizing radiation. The literature suggests incidence rates of 1:500 to 1:3,000 which, however, do not seem to match the very small number of cases reported. Objectives: The aim of the present study was to determine the incidence of morphea following irradiation of the breast in order to generate more evidence about the frequency of this serious and mutilating complication. Method: Retrospective analysis of patient data who underwent adjuvant radiotherapy in the period 2009–2018 following breast-conserving surgery and who made use of the recommended radiooncology follow-up examinations in 2018. Analysis was done by descriptive statistics. Results: Of a total of 5,129 patients who had undergone radiotherapy over a 10-year period, follow-up data were available in 2,268 patients. In 2,236 patients (98.6%) the breast had been irradiated using conventional fractionation schemes with a total dose of 50–50.4 Gy; 32 (1.4%) were given a total dose of 40.05 Gy in 15 fractions. During the observation period, 6 patients were diagnosed with morphea (4 unilateral and 2 bilateral) by punch biopsies resulting in a cumulative incidence proportion of 0.26% (95% CI: 0.24–0.28), translating into 1 case for every 378 irradiated patients. Conclusions: In the case studies reported to date, morphea is described as a very rare complication. In contrast, our data suggest a cumulative incidence of 1:378, which is higher than other authors have estimated. This leads us to suspect that in a large number of patients, morphea is incorrectly diagnosed as an infection (in the early stages) and radiation-induced fibrosis (in later stages).
Late-Life Tourette Syndrome Is a Cause of Unexpected Cursing in the Elderly
Authors: Qualls Clifford , Appenzeller Otto
Published: August 2019

Tourette syndrome is a tic disorder with onset in childhood. By contrast, we report a new Tourette syndrome with onset in late life. We use statistics to support our contention that this behavioral disorder is a hitherto unrecognized variety of Tourette syndrome. There are three tic disorders distinguished by the types of tics present (motor, vocal/ phonic, or both) and by the length of time that the tics have been present. Individuals with chronic tic disorder have either motor tics or vocal tics which have been present for more than 1 year.
Gestão da paisagem, gestão da cidade: quais os legados do Rio de Janeiro Patrimônio Mundial?
Authors: Ribeiro Rafael Winter
Published: August 2019

Este artigo discute a relação entre a inscrição da cidade do Rio de Janeiro na Lista de Patrimônio Mundial da Unesco, a emergência da paisagem como instrumento de políticas públicas e o processo de constituição de novos espaços políticos de gestão do patrimônio e da cidade. Dividido em duas partes, na primeira discute o contexto e legado do processo de inscrição do Rio de Janeiro na Lista de Patrimônio Mundial para a discussão sobre paisagem e política urbana no Brasil, feita a partir de três temas centrais: a paisagem no centro da atenção pública, a ampliação da noção de paisagem empregada e a necessidade de participação através da construção de espaços políticos da gestão. Na segunda parte, tomando a discussão recente da geografia política sobre as características de espaços políticos, através do acompanhamento das reuniões do Comitê Gestor da Paisagem Carioca, o artigo aponta os desafios ainda existentes para conciliar as necessidades e vontades que a inscrição coloca e os entraves para a apropriação de todo o seu potencial, sobretudo para a constituição de novos modelos de gestão mais democráticos a partir de espaços políticos da gestão da cidade e do patrimônio.
Os registros audiovisuais de Ozualdo Candeias e as memórias do Cinema da Boca em Santa Efigênia
Authors: Franco Herta
Published: August 2019

Neste artigo, propomos uma análise da produção do fotógrafo e diretor de cinema Ozualdo Candeias sobre a Rua do Triunfo, no centro de São Paulo, onde estava situado o chamado “Cinema da Boca do Lixo”, entre os anos 1960 e 1980. As obras registram a paisagem e os profissionais engajados na atividade cinematográfica exercida em dezenas de empresas dedicadas à produção, distribuição, locação e exibição de filmes, atraídas para os arredores das estações ferroviárias e rodoviária. As imagens analisadas foram feitas entre os anos 1960 e 2000, período marcado pela refuncionalização do Centro, que incluiu a patrimonialização da região e a formação de um novo polo cultural para a cidade. Assim, além de serem fonte para a história do cinema paulistano, esses registros contribuem para os estudos sobre a história de São Paulo e sobre cultura visual, elucidando aspectos fundamentais para a compreensão das dinâmicas espaciais e sociais existentes na região. Revelam, ainda, uma perspectiva sobre as relações de trabalho ocultada pela narrativa dominante, que estigmatiza a área em razão dos problemas sociais existentes. A partir desses registros, pretende-se identificar elementos recorrentes na construção das memórias do “Cinema da Boca”, uma vez que as obras de Candeias foram frequentemente resgatadas em audiovisuais dedicados ao tema.
Acervos museológicos e a cidade: pensando o acesso ao patrimônio artístico e cultural
Authors: Gobira Pablo , Corrêa Fernanda , De Almeida Karla Danitza
Published: August 2019

Discutimos, neste trabalho, os acervos artísticos em instituições públicas na cidade de Belo Horizonte, Minas Gerais, Brasil. Buscamos compreender como tais espaços têm (ou não têm) desenvolvido políticas de acesso ao seu patrimônio artístico e cultural voltadas para contextos locais (município, estado e país) e internacionais. Procuramos amparo no debate internacional sobre políticas de cultura voltadas para os acervos, bem como analisamos a política local impactada pela relativamente recente preocupação na cidade com as características museológicas de seus equipamentos, como a Política Nacional de Museus (PNM), o Sistema Brasileiro de Museus (SBM) e a Organização das Nações Unidas para a Educação, a Ciência e a Cultura (Unesco). O enfoque em Belo Horizonte se dá objetivamente na escolha de três acervos: o Acervo Artístico Museológico da Universidade do Estado de Minas Gerais (UEMG), o acervo do Museu de Arte da Pampulha (MAP) e o acervo da Academia Mineira de Letras (AML).
Resenha: Domesticidade, gênero e cultura material
Authors: Félix Rogério Ricciluca Matiello
Published: August 2019

Resenha do livro Domesticidade, gênero e cultura material. Organização: Flávia Brito do Nascimento, José Tavares Correia de Lira, Silvana Barbosa Rubino, Joana Mello de Carvalho. 2017.
A Rede Brasileira de Coleções e Museus Universitários: proposição, pesquisa, colaboração e manifestação de apoio ao Museu Nacional da Universidade Federal do Rio de Janeiro e ao Instituto Brasileiro de Museus.
Authors: Silva Mauricio Candido da
Published: August 2019

A Rede Brasileira de Coleções e Museus Universitários surgiu em abril de 2017, a partir de necessidade de articulação entre estudantes, professores, pesquisadores e profissionais que atuam nos museus universitários brasileiros. Seu maior objetivo é a preservação e divulgação do acervo museológico universitário. A Rede funciona cotidianamente por meio de um grupo de e-mail e periodicamente organiza reuniões paralelas dentro de encontros acadêmicos no campo da museologia, em diferentes regiões do Brasil. Após o trágico incêndio ocorrido no Museu Nacional da UFRJ e a publicação da Medida Provisória 850/18, que propõe o fim do Instituto Brasileiro de Museus, a Rede se transformou num importante canal de articulação e manifestação entre diferentes profissionais e pesquisadores envolvidos com a preservação e promoção do patrimônio museológico universitário. O presente trabalho relata e aponta a importância das redes de cooperação como importantes instrumentos estratégicos e operacionais de luta para o processo contínuo e perene característico da preservação e promoção do patrimônio museológico universitário.
Análise dos projetos e das obras no Palácio Foz, em Lisboa, entre 1887 e 1904: contributo para a sua reconstituição arquitetónica e construtiva
Authors: Moreira Anabela Mendes , Serrano Inês Domingues
Published: August 2019

A caracterização arquitetónica e construtiva de um edifício é fundamental em qualquer processo de intervenção. A proficiência desses processos depende, em grande medida, do conhecimento profundo do edifício e da correta interpretação das alterações que nele se tenham operado. A reconstituição construtiva, sobretudo de edifícios mais antigos e que foram submetidos a maior número de intervenções no decurso do tempo, nem sempre é possível, dada a inexistência ou a insuficiência de registos escritos do seu projeto inicial, ou das suas sucessivas alterações. Existem, porém, exceções que se referem principalmente a edifícios com maior notabilidade, onde é possível revisitar o processo projetual, através de registos coevos, e, no caso de obras mais recentes, identificar e analisar os estratos referentes às várias intervenções, através da análise documental geralmente depositada em arquivos institucionais. Neste artigo procede-se à possível reconstituição arquitetónica e construtiva dos elementos do envelope (cobertura e paredes exteriores) de um dos edifícios mais distintos da cidade de Lisboa, o Palácio Foz, erigido na sequência do terramoto de 1755. O trabalho de pesquisa realizado focou-se na análise dos requerimentos submetidos pelo Marquês da Foz à Câmara Municipal de Lisboa no período compreendido entre 1887 e 1904. Os referidos requerimentos correspondem a pedidos escritos de alterações, ampliações e renovações construtivas solicitados pelo proprietário. Este estudo pretende identificar e datar as principais alterações arquitetónicas e construtivas realizadas no envelope do edifício, relativamente à construção inicial, enquadrando-as com as alterações urbanísticas da zona envolvente. Pretende-se, assim, contribuir para a caracterização da história arquitetónica e construtiva do edifício, explicitando a relação entre as práticas construtivas e o contexto urbano durante aquele período.
As Antichità Romane de Piranesi: um projeto para catalogação e conservação das ruínas da Antiguidade no século XVIII
Authors: Rodrigues Angela Rosch
Published: August 2019

Durante o século XVIII, o interesse pela arquitetura da Antiguidade Clássica se amplificou a partir de descobertas arqueológicas na Península Itálica. Nesse contexto, o arquiteto, arqueólogo e gravurista Giovanni Battista Piranesi teve um papel de destaque para o desenvolvimento de questões ligadas à historicização da arquitetura. Foi a partir de seu fascínio pelas ruínas e da observação e das aferições in loco, em especial de Roma e arredores, que Piranesi se estabeleceu como uma referência intelectual e artística, utilizando gravuras e textos como seus principais instrumentos retóricos. Este trabalho tem como objetivo verificar a influência de Piranesi na observação e preservação do passado, tendo como recorte uma de suas obras magnas: as Antichità Romane (1756) – uma publicação em quatro tomos embasada no intuito de conservar as antiguidades por meio da catalogação. A abordagem documental e criativa adotada para as Antichità Romane teve grandes repercussões, nutrindo os debates em curso sobre a investigação do passado, e apresentou reflexos que nortearam os preceitos do restauro moderno, que se cristalizariam a partir do início do século XIX. Pode-se concluir que Piranesi fez uma relevante contribuição para o amadurecimento da forma de se relacionar com o passado, objetivando estudos e a preservação das ruínas por meio de princípios que se tornariam fundamentais para o restauro, como o levantamento pormenorizado, a análise dos edifícios a partir de reconstituições hipotéticas e a predisposição para a conservação e para a mínima intervenção.
Coronary Microcirculation in Aortic Stenosis
Authors: McConkey Hannah Z.R. , Marber Michael , Chiribiri Amedeo , Pibarot Philippe , Redwood Simon R. , Prendergast Bernard D.
Published: August 2019

Aortic stenosis is a heterogeneous disorder. Variations in the pathological and physiological responses to pressure overload are incompletely understood and generate a range of flow and pressure gradient patterns, which ultimately cause varying microvascular effects. The impact of cardiac-coronary coupling depends on these pressure and flow effects. In this article, we explore important concepts concerning cardiac physiology and the coronary microcirculation in aortic stenosis and their impact on myocardial remodeling, aortic valve flow patterns, and clinical progression.
Examining the Operator Learning Curve for Percutaneous Coronary Intervention of Chronic Total Occlusions
Authors: Young Michael N. , Secemsky Eric A. , Kaltenbach Lisa A. , Jaffer Farouc A. , Grantham James A. , Rao Sunil V. , Yeh Robert W.
Published: August 2019

Background:

Advances in chronic total occlusion percutaneous coronary intervention (CTO PCI) techniques have led to increased procedural success rates among operators. While utilization of CTO PCI has disseminated widely, the learning curve for new operators has not been well-defined.

Methods:

Between July 2009 and December 2015, 93 875 CTO PCI cases were extracted from the CathPCI Registry. We delineated a cohort of new CTO operators performing <10 CTO PCI cases per given year. In-hospital outcomes for subsequent CTO PCIs were stratified by the number of prior cases accrued by each operator. Multivariable regression models were used to estimate differences in outcomes with increasing experience. The primary outcome was major adverse cardiovascular events defined as the composite of death, myocardial infarction, stroke, tamponade, or urgent coronary artery bypass grafting.

Results:

Among 70 916 cases performed by 7251 new operators, procedure success rate was 61.4% and major adverse cardiovascular event rate was 4.2%. Meanwhile, the rate of major bleeding was 4.0%, myocardial infarction 2.0%, mortality 0.6%, tamponade 0.3%, and renal failure 0.2%. Adjusted regression models demonstrated piecewise linear improvements in guidewire crossing, stent placement, and procedure success with accrued volume, albeit with increased contrast use, fluoroscopy time, and bleeding. Major adverse cardiovascular event rates were stable beyond the 12th case (odds ratio per 5 case increase 1.00; 95% CI, 0.98–1.03,
P
=0.7980).

Conclusions:

Among a large number of new CTO PCI operators in the United States, there exists an experiential learning curve for procedural success. However, there were higher rates of bleeding despite case experience, while major adverse cardiovascular events remained relatively unchanged after initiation.
Assessment and Treatment of Patients With Type 2 Myocardial Infarction and Acute Nonischemic Myocardial Injury
Authors: DeFilippis Andrew P. , Chapman Andrew R. , Mills Nicholas L. , de Lemos James A. , Arbab-Zadeh Armin , Newby L. Kristin , Morrow David A.
Published: August 2019

Although coronary thrombus overlying a disrupted atherosclerotic plaque has long been considered the hallmark and the primary therapeutic target for acute myocardial infarction (MI), multiple other mechanisms are now known to cause or contribute to MI. It is further recognized that an MI is just one of many types of acute myocardial injury. The Fourth Universal Definition of Myocardial Infarction provides a taxonomy for acute myocardial injury, including 5 subtypes of MI and nonischemic myocardial injury. The diagnosis of MI is reserved for patients with myocardial ischemia as the cause of myocardial injury, whether attributable to acute atherothrombosis (type 1 MI) or supply/demand mismatch without acute atherothrombosis (type 2 MI). Myocardial injury in the absence of ischemia is categorized as acute or chronic nonischemic myocardial injury. However, optimal evaluation and treatment strategies for these etiologically distinct diagnoses have yet to be defined. Herein, we review the epidemiology, risk factor associations, and diagnostic tools that may assist in differentiating between nonischemic myocardial injury, type 1 MI, and type 2 MI. We identify limitations, review new research, and propose a framework for the diagnostic and therapeutic approach for patients who have suspected MI or other causes of myocardial injury.
The Neural Correlates of Time: A Meta-analysis of Neuroimaging Studies
Authors: Nani Andrea , Manuello Jordi , Liloia Donato , Duca Sergio , Costa Tommaso , Cauda Franco
Published: August 2019

During the last two decades, our inner sense of time has been repeatedly studied with the help of neuroimaging techniques. These investigations have suggested the specific involvement of different brain areas in temporal processing. At least two distinct neural systems are likely to play a role in measuring time: One is mainly constituted of subcortical structures and is supposed to be more related to the estimation of time intervals below the 1-sec range (subsecond timing tasks), and the other is mainly constituted of cortical areas and is supposed to be more related to the estimation of time intervals above the 1-sec range (suprasecond timing tasks). Tasks can then be performed in motor or nonmotor (perceptual) conditions, thus providing four different categories of time processing. Our meta-analytical investigation partly confirms the findings of previous meta-analytical works. Both sub- and suprasecond tasks recruit cortical and subcortical areas, but subcortical areas are more intensely activated in subsecond tasks than in suprasecond tasks, which instead receive more contributions from cortical activations. All the conditions, however, show strong activations in the SMA, whose rostral and caudal parts have an important role not only in the discrimination of different time intervals but also in relation to the nature of the task conditions. This area, along with the striatum (especially the putamen) and the claustrum, is supposed to be an essential node in the different networks engaged when the brain creates our sense of time.
Neural Mechanisms for Monitoring and Halting of Spoken Word Production
Authors: Hansen Samuel J. , McMahon Katie L. , de Zubicaray Greig I.
Published: August 2019

During conversation, speakers monitor their own and others' output so they can alter their production adaptively, including halting it if needed. We investigated the neural mechanisms of monitoring and halting in spoken word production by employing a modified stop signal task during fMRI. Healthy participants named target pictures and withheld their naming response when presented with infrequent auditory words as stop signals. We also investigated whether the speech comprehension system monitors inner (i.e., prearticulatory) speech via the output of phonological word form encoding as proposed by the perceptual loop theory [Levelt, W. J. M. Speaking: From intention to articulation. Cambridge, MA: MIT Press, 1989] by presenting stop signals phonologically similar to the target picture name (e.g., cabbage–CAMEL). The contrast of successful halting versus naming revealed extensive BOLD signal responses in bilateral inferior frontal gyrus, preSMA, and superior temporal gyrus. Successful versus unsuccessful halting of speech was associated with increased BOLD signal bilaterally in the posterior middle temporal, frontal, and parietal lobes and decreases bilaterally in the posterior and left anterior superior temporal gyrus and right inferior frontal gyrus. These results show, for the first time, the neural mechanisms engaged during both monitoring and interrupting speech production. However, we failed to observe any differential effects of phonological similarity in either the behavioral or neural data, indicating monitoring of inner versus external speech might involve different mechanisms.
Is There Such a Thing as Orthogonyms?
Authors: Raykowski Wes
Published: August 2019

The article explores the cognitive semantics thesis that lexical expressions function as points of access to vast repositories of schematic concepts arising from embodied experience. By comparing various forms of communication, I find that expressions in art, science, and technology display a pattern in which expressions prompting the sense of intensity, magnitude and force are often combined into products with expressions that prompt the sense of extent, multitude and displacement. This pattern seems to be largely absent from natural language. I argue that lexical items activate the same pattern, though in a less direct way.
Cognitive Semantics, Linguistic Typology and Grammatical Polysemy: “Possession” and the English Genitive
Authors: Goddard Cliff , Wierzbicka Anna
Published: August 2019

This paper explores the cognitive semantics of the typological category “possession” using the Natural Semantic Metalanguage (nsm) approach. At the macro level, we argue that “possession” is not a unitary cognitive category for speakers, but instead represents an aggregation of diverse semantic schemas which center around three distinct conceptual anchor points: ownership, body-parts, and kinship relations. It is shown how each of these conceptual anchor points can be clearly identified using the nsm metalanguage of semantic primes and molecules. At the micro level, the paper undertakes a close examination of the cognitive semantics of English s-genitives in the frame [THIS SOMEONE’S] SOMETHING, e.g. Mary’s ring, Mary’s shoes, Mary’s drawing, Mary’s plate, Mary’s train. It is argued that the wide range of use of the s-genitive can be captured in a set of five semantic schemas, which constitute a network of grammatical polysemy.
Cabdio crassus, a new species of cyprinid fish (Teleostei: Cyprinidae) from the Kaladan River of Mizoram, India
Authors: LALRAMLIANA LALRAMLIANA , LALRONUNGA SAMUEL , SINGH MAHENDER
Published: August 2019

Cabdio crassus, a new fish species, is described from the Kaladan River in Mizoram, India. The new species is distinguished from all its congeners by having a ventral keel extending from the middle of the chest, between the posterior base of the pectoral fin and along the abdomen up to the anus (vs. more or less keeled median scales from mid-point of abdomen between posterior base of pelvic fin up to anus in all other Cabdio) and 11½–12½ branched anal-fin rays (vs. 7 in C. jaya and 9 in both C. morar and C. ukhrulensis). It is further distinguished from C. morar and C. ukhrulensis by possessing more lateral-line scales (45–51 vs. 38–42 in C. morar and 35–37 in C. ukhrulensis), more predorsal scales (20–23 vs. 17–18 in C. morar and 14 in C. ukhrulensis) and more lateral transverse scales (½7/1/3½ vs. 5/1/2 in both C. morar and C. ukhrulensis). It also differs from C. jaya in having fewer lateral-line scales (45–51 vs. 52–60), more lateral transverse scales (½7/1/3½ vs. 5/1/3) and more pharyngeal tooth-rows (3 vs. 2). Furthermore, the cytochrome c oxidase sub unit I (coi) gene sequence separates Cabdio crassus from all other Cabdio species (interspecies distance ranges from 7.8–12.3%). The anomalies observed among the GenBank sequences of the genus Cabdio are discussed and resolved.
Attenuation Correction over Ocean for the HIWRAP Dual-Frequency Airborne Scatterometer
Authors: Meneghini R. , Liao L. , Heymsfield G. M.
Published: August 2019

An important objective in scatterometry is the estimation of near-surface wind speed and direction in the presence of rain. We investigate an attenuation correction method using data from the High-Altitude Imaging Wind and Rain Airborne Profiler (HIWRAP) dual-frequency scatterometer, which operates at Ku and Ka band with dual conical scans at incidence angles of 30° and 40°. The method relies on the fact that the differential normalized surface cross section, δσ
0 = σ
0(Ka) − σ
0(Ku), is relatively insensitive to wind speed and direction and that this quantity is closely related to the magnitude of the differential path attenuation, δA = A(Ka) − A(Ku), arising from precipitation, cloud, and atmospheric gases. As the method relies only on the difference between quantities measured in the presence and absence of rain, the estimates are independent of radar calibration error. As a test of the method’s accuracy, we make use of the fact that the radar rain reflectivities just above the surface, as seen along different incidence angles, are approximately the same. This yields constraint equations in the form of differences between pairs of path attenuations along different lines of sight to the surface. A second validation method uses the dual-frequency radar returns from the rain just above the surface where it can be shown that the difference between the Ku- and Ka-band-measured radar reflectivity factors provide an estimate of differential path attenuation. Comparisons between the path attenuations derived from the normalized surface cross section and those from these surface-independent methods generally show good agreement.