bluuebunny/crossref_metadata_2025 huggingface dataset:
Kinetic analysis of dominant intraprostatic lesion of prostate cancer using quantitative dynamic [18F]DCFPyL-PET: comparison to [18F]fluorocholine-PET
Authors: Yang Dae-Myoung , Li Fiona , Bauman Glenn , Chin Joseph , Pautler Stephen , Moussa Madeleine , Rachinsky Irina , Valliant John , Lee Ting-Yim
Published: January 2021

Purpose

Identification of the dominant intraprostatic lesion(s) (DILs) can facilitate diagnosis and treatment by targeting biologically significant intra-prostatic foci. A PSMA ligand, [18F]DCFPyL (2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid), is better than choline-based [18F]FCH (fluorocholine) in detecting and localizing DIL because of higher tumour contrast, particularly when imaging is delayed to 1 h post-injection. The goal of this study was to investigate whether the different imaging performance of [18F]FCH and [18F]DCFPyL can be explained by their kinetic behaviour in prostate cancer (PCa) and to evaluate whether DIL can be accurately detected and localized using a short duration dynamic positron emission tomography (PET).

Methods

19 and 23 PCa patients were evaluated with dynamic [18F]DCFPyL and [18F]FCH PET, respectively. The dynamic imaging protocol with each tracer had a total imaging time of 22 min and consisted of multiple frames with acquisition times from 10 to 180 s. Tumour and benign tissue regions identified by sextant biopsy were compared using standardized uptake value (SUV) and tracer kinetic parameters from kinetic analysis of time-activity curves.

Results

For [18F]DCFPyL, logistic regression identified Ki and k4 as the optimal model to discriminate tumour from benign tissue (84.2% sensitivity and 94.7% specificity), while only SUV was predictive for [18F]FCH (82.6% sensitivity and 87.0% specificity). The higher k3 (binding) of [18F]FCH than [18F]DCFPyL explains why [18F]FCH SUV can differentiate tumour from benign tissue within minutes of injection. Superior [18F]DCFPyL tumour contrast was due to the higher k4/k3 (more rapid washout) in benign tissue compared to tumour tissue.

Conclusions

DIL was detected with good sensitivity and specificity using 22-min dynamic [18F]DCFPyL PET and avoids the need for delayed post-injection imaging timepoints. The dissimilar in vivo kinetic behaviour of [18F]DCFPyL and [18F]FCH could explain their different SUV images.

Clinical Trial Registration NCT04009174 (ClinicalTrials.gov).
Streptococci as the new dominant aetiological factors of mastitis in dairy cows in north-eastern Poland: analysis of the results obtained in 2013–2019
Authors: Kaczorek-Łukowska E. , Małaczewska J. , Wójcik R. , Duk K. , Blank A. , Siwicki A. K.
Published: January 2021

The objective of our study was to evaluate prevalence of selected bacterial and fungal pathogens of mastitis in dairy cattle in north-eastern Poland. Our study was conducted from 2013 to 2019 in 1,665 clinically and sub-clinically infected quarter milk samples (2013, n = 368; 2014, n = 350; 2015, n = 290; 2016, n = 170; 2017, n = 173; 2018, n = 224; and 2019, n = 90). The isolation and identification of the pathogens were performed in keeping with generally accepted microbiological procedures. In 2013, mastitis was most commonly caused by Staphylococcus aureus (24%), Streptococcus spp. (22%), Streptococcus agalactiae (12%) and coagulase-negative staphylococci (11%). In 2014, the most common pathogens were Streptococcus spp. (25%), Staphylococcus aureus (18%) and coagulase-negative staphylococci (10%); in 2015, 2016, 2017, 2018 and 2019, Streptococcus spp. (from 39–49%) were the most frequent strains isolated from the quarter milk samples. Other pathogens were isolated occasionally (below 15% in all years). In conclusion, the role of environmental bacteria has been gradually increasing in the Warmia Province. The importance of infectious pathogens has been decreasing, indicating the efficacy of the applied preventive programmes and a need for the development of new programmes targeting environmental pathogens.
Effectiveness of task-shifting for the detection of diabetic retinopathy in low- and middle-income countries: a rapid review protocol
Authors: Bascaran Covadonga , Mwangi Nyawira , D’Esposito Fabrizio , Gordon Iris , Ulloa Juan Alberto Lopez , Mdala Shaffi , Ramke Jacqueline , Evans Jennifer R. , Burton Matthew
Published: January 2021

Background

Diabetic retinopathy is the most common ocular complication of diabetes and a cause of vision loss in adults. Diabetic retinopathy screening leading to early identification of the disease followed by timely treatment, can prevent vision loss in people living with diabetes. A key barrier to the implementation of screening services in low- and middle-income countries is the low number of ophthalmologists per million population. Interventions that shift screening to non-ophthalmology cadres have been implemented in programmes in low- and middle-income countries and are routinely used in high-income countries. The aim of this rapid review is to summarise the published literature reporting the effectiveness of task-shifting interventions for the detection of diabetic retinopathy by non-ophthalmologists in low- and middle-income countries.

Methods

We will search MEDLINE, Embase, Global Health and Cochrane Register of Studies for studies reporting task-shifting interventions for diabetic retinopathy detection. The review will include studies published in the last 10 years in the English language. We will include any interventional or observational comparative study measuring outcomes in terms of participation or access to diabetic retinopathy detection services (uptake) and quality of diabetic retinopathy detection services (detection, severity, diagnostic accuracy). For included studies, cost-effectiveness of the task-shifting intervention will also be presented. Two reviewers will screen search results independently. The risk of bias assessment and data extraction will be carried out by one reviewer with verification of 10% of the papers by a second reviewer. The results will be synthesised narratively.

Discussion

Differences in health systems organization, structure and resources will determine the need and success of task-shifting interventions for DR screening. The review will examine how these interventions have been used and/or tested in LMICs. The results will be of interest to policy makers and programme managers tasked with designing and implementing services to prevent and manage diabetes and its complications in similar settings.

Systematic review registration

OSF: https://osf.io/dfhg6/.
Comparison of respiratory pathogen colonization and antimicrobial susceptibility in people with cystic fibrosis bronchiectasis versus non-cystic fibrosis bronchiectasis: a protocol for a systematic review
Authors: Verma Salony , Mathew Joseph L. , Ray Pallab
Published: January 2021

Background

Both cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis are characterized by permanent bronchial dilation, impaired mucociliary clearance, and development of chronic colonization and infection. Although the major airway microbiota in both CF and non-CF bronchiectasis may be similar, there are some differences in clinical and microbiologic features. There may also be differences in antibiotic susceptibility patterns between the CF and non-CF populations. Therefore, analysis and comparison of the microbiota and antibiotic susceptibility pattern in CF bronchiectasis versus non-CF bronchiectasis would help to improve the management of both conditions.

Methods

Two authors will independently search the electronic databases PubMed, EMBASE, the Cochrane Library, and LIVIVO, for studies reporting bacterial colonization of the respiratory tract in adults and children diagnosed with bronchiectasis in either CF or non-CF. We will include studies examining any respiratory tract specimen, using conventional bacterial culture or other specialized techniques such as molecular methods. We will also examine the antimicrobial susceptibility patterns in people with CF bronchiectasis versus non-CF bronchiectasis. The authors will independently assess the risk of bias in each included study using the Newcastle Ottawa Scale (NOS). We will present the data with descriptive statistics and provide pooled estimates of outcomes, wherever it is feasible to perform meta-analysis. Heterogeneity in studies will be explored by visual inspection of forest plots as well as using the Higgins and Thompson I2 method. We will contact the corresponding authors of studies where data is/are missing and try to obtain the missing data. We will undertake sensitivity analysis to explore the impact of study quality and subgroup analysis based on pre-set criteria. We will prepare a summary of findings’ table and assess the confidence in the evidence using the GRADE methodology.

Discussion

To date, there are no locally applicable evidence-based guidelines for antimicrobial treatment of non-CF bronchiectasis patients. In general, treatment is based on extrapolation of evidence in people with CF bronchiectasis. An insight into the microbiota and antimicrobial susceptibility patterns in the two conditions would facilitate appropriate rather than empiric antimicrobial therapy and hopefully reduce the burden of antimicrobial resistance created by rampant usage of antibiotics.

Systematic review registration

The protocol has been registered in PROSPERO on July 26, 2020 (PROSPERO registration number: CRD42020193859).
$L^{\infty }$ decay estimates of solutions of nonlinear parabolic equation
Authors: Wang Hui , Chen Caisheng
Published: January 2021

In this paper, we are interested in $L^{\infty }$

L
∞

decay estimates of weak solutions for the doubly nonlinear parabolic equation and the degenerate evolution m-Laplacian equation not in the divergence form. By a modified Moser’s technique we obtain $L^{\infty }$

L
∞

decay estimates of weak solutiona.
Current and near-term advances in Earth observation for ecological applications
Authors: Ustin Susan L. , Middleton Elizabeth M.
Published: January 2021

There is an unprecedented array of new satellite technologies with capabilities for advancing our understanding of ecological processes and the changing composition of the Earth’s biosphere at scales from local plots to the whole planet. We identified 48 instruments and 13 platforms with multiple instruments that are of broad interest to the environmental sciences that either collected data in the 2000s, were recently launched, or are planned for launch in this decade. We have restricted our review to instruments that primarily observe terrestrial landscapes or coastal margins and are available under free and open data policies. We focused on imagers that passively measure wavelengths in the reflected solar and emitted thermal spectrum. The suite of instruments we describe measure land surface characteristics, including land cover, but provide a more detailed monitoring of ecosystems, plant communities, and even some species then possible from historic sensors. The newer instruments have potential to greatly improve our understanding of ecosystem functional relationships among plant traits like leaf mass area (LMA), total nitrogen content, and leaf area index (LAI). They provide new information on physiological processes related to photosynthesis, transpiration and respiration, and stress detection, including capabilities to measure key plant and soil biophysical properties. These include canopy and soil temperature and emissivity, chlorophyll fluorescence, and biogeochemical contents like photosynthetic pigments (e.g., chlorophylls, carotenoids, and phycobiliproteins from cyanobacteria), water, cellulose, lignin, and nitrogen in foliar proteins. These data will enable us to quantify and characterize various soil properties such as iron content, several types of soil clays, organic matter, and other components. Most of these satellites are in low Earth orbit (LEO), but we include a few in geostationary orbit (GEO) because of their potential to measure plant physiological traits over diurnal periods, improving estimates of water and carbon budgets. We also include a few spaceborne active LiDAR and radar imagers designed for quantifying surface topography, changes in surface structure, and 3-dimensional canopy properties such as height, area, vertical profiles, and gap structure. We provide a description of each instrument and tables to summarize their characteristics. Lastly, we suggest instrument synergies that are likely to yield improved results when data are combined.
Efforts to mitigate the economic impact of the COVID-19 pandemic: potential entry points for neglected tropical diseases
Authors: Ehrenberg John P. , Utzinger Jürg , Fontes Gilberto , da Rocha Eliana Maria Mauricio , Ehrenberg Nieves , Zhou Xiao-Nong , Steinmann Peter
Published: January 2021

Background

The damage inflicted by the coronavirus diseases 2019 (COVID-19) pandemic upon humanity is and will continue to be considerable. Unprecedented progress made in global health over the past 20 years has reverted and economic growth has already evaporated, giving rise to a global recession, the likes of which we may not have experienced since the Second World War. Our aim is to draw the attention of the neglected tropical disease (NTD) community towards some of the major emerging economic opportunities which are quickly appearing on the horizon as a result of COVID-19.

Main text

This scoping review relied on a literature search comprised of a sample of articles, statements, and press releases on initiatives aimed at mitigating the impact of COVID-19, while supporting economic recovery. Of note, the donor scenario and economic development agendas are highly dynamic and expected to change rapidly as the COVID-19 pandemic unfolds, as are donor and lender priorities.

Conclusions

The NTD community, particularly in low- and middle-income countries (LMICs), will need to work quickly, diligently, and in close collaboration with decision-makers and key stakeholders, across sectors at national and international level to secure its position. Doing so might enhance the odds of grasping potential opportunities to access some of the massive resources that are now available in the form of contributions from corporate foundations, trust funds, loans, debt relieve schemes, and other financial mechanisms, as part of the ongoing and future economic development agendas and public health priorities driven by the COVID-19 pandemic. This paper should serve as a starting point for the NTD community to seek much needed financial support in order to sustain and revitalize control and elimination efforts pertaining to NTDs in LMICs.
What factors are most important for the development of the maternal–fetal relationship? A prospective study among pregnant women in Danish general practice
Authors: Ertmann Ruth K. , Bang Christine W. , Kriegbaum Margit , Væver Mette S. , Kragstrup Jakob , Siersma Volkert , Wilson Philip , Lutterodt Melissa C. , Smith-Nielsen Johanne
Published: January 2021

Background

Development of the maternal antenatal attachment (MAA) constitutes an important aspect of the transition into motherhood. Early identification of women at risk of developing a poor MAA provides possibilities for preventive interventions targeting maternal mental health and the emerging mother-infant relationship. In this study, we investigate the relative importance of an extensive set of psychosocial, pregnancy-related, and physiological factors measured in the first trimester of pregnancy for MAA measured in third trimester.

Methods

A prospective study was conducted among pregnant women in Danish general practice (GP). Data were obtained in the first and the third trimester from pregnancy health records and electronic questionnaires associated with routine GP antenatal care visits. The Maternal Antenatal Attachment Scale (MAAS) was used to assess maternal antenatal attachment. The relative importance of potential determinants of maternal antenatal attachment was assessed by the relative contribution of each factor to the fit (R2) calculated from multivariable regression models.

Results

The sample consisted of 1328 women. Low antenatal attachment (Total MAAS ≤ 75) was observed for 513 (38.6%) women. Perceived social support (having someone to talk to and having access to practical help when needed) emerged as the most important determinant. Furthermore, scores on the MAAS decreased with worse self-rated health, poor physical fitness, depression, increasing age, having given birth previously, and higher education.

Conclusion

Pregnant women reporting lack of social support and general low physical and mental well-being early in pregnancy may be at risk for developing a poor MAA. An approach targeting both psychosocial and physiological well-being may positively influence expectant mothers’ successful adaptation to motherhood.
An eye-tracking study of interpersonal threat sensitivity and adverse childhood experiences in borderline personality disorder
Authors: Seitz Katja I. , Leitenstorfer Johanna , Krauch Marlene , Hillmann Karen , Boll Sabrina , Ueltzhoeffer Kai , Neukel Corinne , Kleindienst Nikolaus , Herpertz Sabine C. , Bertsch Katja
Published: January 2021

Background

Previous eye-tracking studies provide preliminary evidence for a hypersensitivity to negative, potentially threatening interpersonal cues in borderline personality disorder (BPD). From an etiological point of view, such interpersonal threat hypersensitivity might be explained by a biological vulnerability along with a history of early life adversities. The objective of the current study was to investigate interpersonal threat hypersensitivity and its association with adverse childhood experiences (ACE) in patients with BPD employing eye-tracking technology.

Methods

We examined a sample of 46 unmedicated, adult female patients with BPD and 25 healthy female volunteers, matched on age and intelligence, with a well-established emotion classification paradigm with angry, fearful, happy, and neutral facial expressions. ACE were assessed retrospectively with the Childhood Trauma Questionnaire.

Results

Patients as compared to healthy volunteers reflexively directed their gaze more quickly towards the eyes of emotional and neutral faces and did not adapt their fixation patterns according to the facial expression presented. Misclassifying emotional and neutral faces as angry correlated positively with the patients’ self-reported ACE.

Conclusions

Building on and extending earlier findings, our results are likely to suggest a visual hypervigilance towards the eyes of emotional and neutral facial expressions and a childhood trauma-related anger bias in patients with BPD. Given the lack of a clinical control group, the question whether these findings are specific for BPD has to remain open. Thus, further research is needed to elucidate the specificity of altered visual attention allocation and the role of ACE in anger recognition in patients with BPD.
Study on thickness-dependence characteristics of bismuth ferrite (BFO) for ultraviolet (UV) photodetector application
Authors: Kossar Shahnaz , Amiruddin R. , Rasool Asif
Published: January 2021

The present research work reports on the fabrication of ultraviolet (UV) photodetectors using bismuth ferrite (BiFeO3, BFO) thin films with varying thickness. Using the spray pyrolysis technique, BFO thin films were deposited on the glass substrate at 673 K. The deposited BFO thin films were characterized by Raman and FTIR spectroscopic analysis. The morphological analysis reveals uniform grain distribution for the prepared BFO samples. The optical analysis reveals that transmittance value decreases upon an increase in the thickness of BFO thin films and the calculated optical band gap value lies between 2.0 to 2.3 eV. The varying thickness of the BFO active layer was stacked between ITO and Al electrodes and the current–voltage (I–V) characteristics of the fabricated ITO/BFO/Al devices were studied under dark and UV illumination (λ = 365 nm). It was observed that BFO with an optimum thickness (365 nm) exhibits higher photoresponsivity of 110 mA/W with an external quantum efficiency (EQE) of 37.30%. The impact of different thickness of the BFO active layer, the role of adsorption and desorption of oxygen (O2) molecules upon the surface of BFO layers towards UV photoresponse characteristics were investigated.
Inappropriate antibiotic prescribing for acute bronchiolitis in Colombia: a predictive model
Authors: Buendía Jefferson Antonio , Feliciano-Alfonso John Edwin
Published: January 2021

Introduction

Acute bronchiolitis is the leading cause of hospitalization in the pediatric population. The inappropriate prescription of antibiotics in acute bronchiolitis is associated with bacterial resistance, higher costs, and risk of adverse effects in this population. The objective of this work is to develop a predictive model of inappropriate use of antibiotics in children with acute bronchiolitis in Colombia.

Methods

A retrospective cohort study was conducted in patients under 2 years of age with a diagnosis of acute bronchiolitis from two hospitals in Rionegro, Colombia. To identify factors independently associated with inappropriate use of antibiotics, we used logistic regression and estimated odds ratios (ORs). To assess discrimination, area under the curve (AUC) was estimated with a 95% confidence interval and plotted using AUC–ROC plots. To correct sampling bias of variance parameters and to evaluate the internal validity of the model, repeated curved validation “tenfold cross-validation” was used, comparing the area under the ROC curve obtained in the repetitions with that observed in the model

Results

A total of 415 patients were included. 142 patients (34.13%) had a prescription of some antibiotic during their hospital stay. In 92 patients (64.78%, 95% CI 56.3 to 72.6%) the prescription of antibiotics was classified as inappropriate. Age older than 1 year, chest retractions, temperature between 37.5 °C and 38.5 °C and leukocyte count between 10,000 and 15,000 million/mm3 were the predictive variables of inappropriate use of medications in this population.

Conclusion

The presence of fever between 37.5 °C and 38.5 °C, leukocytosis between 10,000 and 15,000 million/mm3, and age older than 1 year and presence of chest retractions, should alert the physician regarding the high risk of inappropriate prescription of antibiotics. Patients with acute bronchiolitis with a score on our scale greater than 2 should be carefully evaluated regarding the need for the use of antibiotics, if prescribed.
Magnetotelluric study in the Los Lagos Region (Chile) to investigate volcano-tectonic processes in the Southern Andes
Authors: Segovia Maria Jose , Diaz Daniel , Slezak Katarzyna , Zuñiga Felipe
Published: January 2021

To analyze the process of subduction of the Nazca and South American plates in the area of the Southern Andes, and its relationship with the tectonic and volcanic regime of the place, magnetotelluric measurements were made through a transversal profile of the Chilean continental margin. The data-processing stage included the analysis of dimensional parameters, which as first results showed a three-dimensional environment for periods less than 1 s and two-dimensional for periods greater than 10 s. In addition, through the geomagnetic transfer function (tipper), the presence of structural electrical anisotropy was identified in the data. After the dimensional analysis, a deep electrical resistivity image was obtained by inverting a 2D and a 3D model. Surface conductive anomalies were obtained beneath the central depression related to the early dehydration of the slab and the serpentinization process of the mantle that coincides in location with a discontinuity in the electrical resistivity of a regional body that we identified as the Nazca plate. A shallow conductive body was located around the Calbuco volcano and was correlated with a magmatic chamber or reservoir which in turn appears to be connected to the Liquiñe Ofqui fault system and the Andean Transverse Fault system. In addition to the serpentinization process, when the oceanic crust reaches a depth of 80–100 km, the ascending fluids produced by the dehydration and phase changes of the minerals present in the oceanic plate produce basaltic melts in the wedge of the subcontinental mantle that give rise to an eclogitization process and this explains a large conductivity anomaly present beneath the main mountain range.
Strength models of the terrestrial planets and implications for their lithospheric structure and evolution
Authors: Katayama Ikuo
Published: January 2021

Knowledge of lithospheric strength can help to understand the internal structure and evolution of the terrestrial planets, as surface topography and gravity fields are controlled mainly by deformational features within the lithosphere. Here, strength profiles of lithosphere were calculated for each planet using a recently updated flow law and taking into account the effect of water on lithospheric deformation. Strength is controlled predominantly by brittle deformation at shallow depths, whereas plastic deformation becomes dominant at greater depths through its sensitivity to temperature. Incorporation of Peierls creep, in which strain rate is exponentially dependent on stress, results in the weakening of plastic strength at higher stress levels, and the transition from brittle to ductile deformation shifts to shallower depths than those calculated using conventional power-law creep. Strength in both the brittle and ductile regimes is highly sensitive to the presence of water, with the overall strength of the lithosphere decreasing markedly under wet conditions. The markedly low frictional coefficient of clay minerals results in a further decrease in brittle strength and is attributed to expansion of the brittle field. As plastic strength is influenced by lithology, a large strength contrast can occur across the crust–mantle boundary if deformation is controlled by ductile deformation. Effective elastic thickness for the terrestrial planets calculated from the rheological models indicates its close dependence on spatiotemporal variations in temperature and the presence of water. Although application of the strength models to observed large-scale surface deformational features is subject to large extrapolation and uncertainties, I emphasize the different sensitivity of these features to temperature and water, meaning that quantifying these features (e.g., by data from orbiting satellites or rovers) should help to constrain the internal structure and evolution of the terrestrial planets.
History matters: the long-term impact of historical immigrant size on current xenophobia in Japan
Authors: Gong Shun , Wang Senhu
Published: January 2021

Many studies have addressed how current immigrant size affects the strength of xenophobia from the perspectives of intergroup contact and ethnic competition theories. Can native residents’ current xenophobia be explained by historical immigrant size? To explore this question, we use historical immigrant size and a survey dataset to investigate the long-term effects of historical immigrant size on current xenophobia in Japan. The results show that historical immigrant size increases current xenophobia in Japan, which may be due to previous negative contact experiences between immigrants and native residents, and the negative effects persist. The implications of these findings for our understanding of the relationship between immigrant size and xenophobia are discussed.
Fentanyl compared to buprenorphine for atrial fibrillation ablation analgesia and sedation: a retrospective cross-sectional study
Authors: Kinoshita Teruhisa , Harada Mitsunori , Takimoto Norio , Shibata Daichi , Sakakibara Takashi , Adachi Mamoru
Published: January 2021

Background

The effects of general anesthesia with deep sedation and conscious sedation have been compared for sedation management in the perioperative period for radiofrequency catheter ablation of the heart to treat atrial fibrillation. However, there is no consensus as to which drug to use for conscious sedation. This study aimed to investigate analgesic and sedative drugs suitable for perioperative ablation.

Methods

We retrospectively examined 93 patients who underwent atrial fibrillation ablation at Kariya Toyoda General Hospital between December 2017 and April 2019 and investigated differences in the outcomes, such as depth of sedation and postoperative adverse events between the buprenorphine hydrochloride (n = 46) and fentanyl citrate (n = 47) groups.

Results

The depth of sedation was similar between the two groups, without significant between-group differences in postoperative vomiting. The number of additional injections of thiamylal sodium to manage discomfort and pain during ablation were significantly lower in the fentanyl group. Additionally, the cumulative area product, cumulative total air kerma, 1-year postoperative atrial fibrillation recurrence rate, and postoperative complications were not significantly different between the two groups.

Conclusions

Although there were no significant differences in the efficacy or safety between buprenorphine hydrochloride and fentanyl citrate as analgesics used during atrial fibrillation ablation, intraoperative body movements and patient discomfort could be reduced to a greater extent with the use of fentanyl.
Development of an intervention to increase adherence to nebuliser treatment in adults with cystic fibrosis: CFHealthHub
Authors: Arden M. A. , Hutchings M. , Whelan P. , Drabble S. J. , Beever D. , Bradley J. M. , Hind D. , Ainsworth J. , Maguire C. , Cantrill H. , O’Cathain A. , Wildman M.
Published: January 2021

Background

Cystic fibrosis (CF) is a life-limiting genetic condition in which daily therapies to maintain lung health are critical, yet treatment adherence is low. Previous interventions to increase adherence have been largely unsuccessful and this is likely due to a lack of focus on behavioural evidence and theory alongside input from people with CF. This intervention is based on a digital platform that collects and displays objective nebuliser adherence data. The purpose of this paper is to identify the specific components of an intervention to increase and maintain adherence to nebuliser treatments in adults with CF with a focus on reducing effort and treatment burden.

Methods

Intervention development was informed by the Behaviour Change Wheel (BCW) and person-based approach (PBA). A multidisciplinary team conducted qualitative research to inform a needs analysis, selected, and refined intervention components and methods of delivery, mapped adherence-related barriers and facilitators, associated intervention functions and behaviour change techniques, and utilised iterative feedback to develop and refine content and processes.

Results

Results indicated that people with CF need to understand their treatment, be able to monitor adherence, have treatment goals and feedback and confidence in their ability to adhere, have a treatment plan to develop habits for treatment, and be able to solve problems around treatment adherence. Behaviour change techniques were selected to address each of these needs and were incorporated into the digital intervention developed iteratively, alongside a manual and training for health professionals. Feedback from people with CF and clinicians helped to refine the intervention which could be tailored to individual patient needs.

Conclusions

The intervention development process is underpinned by a strong theoretical framework and evidence base and was developed by a multidisciplinary team with a range of skills and expertise integrated with substantial input from patients and clinicians. This multifaceted development strategy has ensured that the intervention is usable and acceptable to people with CF and clinicians, providing the best chance of success in supporting people with CF with different needs to increase and maintain their adherence. The intervention is being tested in a randomised controlled trial across 19 UK sites.
Green bonds issuance: insights in low- and middle-income countries
Authors: Otek Ntsama Ursule Yvanna , Yan Chen , Nasiri Alireza , Mbouombouo Mboungam Abdel Hamid
Published: January 2021

Former reports of Environmental, Social and Governance (ESG) tended to focus on the equity side of investing, and today green bonds also offer and introduce sustainability factors. This paper is about the relevance, potential benefits and key arguments for countries with low-and middle-incomes where financial markets are not comparable with those in developed countries. We begin by stating clearly the relevance of a green economy transformation, highlight the development challenges they face and talk about how a green economy approach can help to solve these challenges. Then an outline of the progress that has been made in this panel, and the economic and social benefits that a green economy can potentially offer to Low- and Middle-Income countries (LMIC’s) will be underlined. Finally, we will make recommendations on the range of potential areas for intervention.
Identification of differentially expressed genes, signaling pathways and immune infiltration in rheumatoid arthritis by integrated bioinformatics analysis
Authors: Ge Yanzhi , Zhou Li , Chen Zuxiang , Mao Yingying , Li Ting , Tong Peijian , Shan Letian
Published: January 2021

Background

The disability rate associated with rheumatoid arthritis (RA) ranks high among inflammatory joint diseases. However, the cause and potential molecular events are as yet not clear. Here, we aimed to identify differentially expressed genes (DEGs), pathways and immune infiltration involved in RA utilizing integrated bioinformatics analysis and investigating potential molecular mechanisms.

Materials and methods

The expression profiles of GSE55235, GSE55457, GSE55584 and GSE77298 were downloaded from the Gene Expression Omnibus database, which contained 76 synovial membrane samples, including 49 RA samples and 27 normal controls. The microarray datasets were consolidated and DEGs were acquired and further analyzed by bioinformatics techniques. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of DEGs were performed using R (version 3.6.1) software, respectively. The protein-protein interaction (PPI) network of DEGs were developed utilizing the STRING database. Finally, the CIBERSORT was used to evaluate the infiltration of immune cells in RA.

Results

A total of 828 DEGs were recognized, with 758 up-regulated and 70 down-regulated. GO and KEGG pathway analyses demonstrated that these DEGs focused primarily on cytokine receptor activity and relevant signaling pathways. The 30 most firmly related genes among DEGs were identified from the PPI network. The principal component analysis showed that there was a significant difference between the two tissues in infiltration immune.

Conclusion

This study shows that screening for DEGs, pathways and immune infiltration utilizing integrated bioinformatics analyses could aid in the comprehension of the molecular mechanisms involved in RA development. Besides, our study provides valuable data related to DEGs, pathways and immune infiltration of RA and may provide new insight into the understanding of molecular mechanisms.
The moderation effect of identity exploration and basic psychological needs satisfaction on flourishing of Chinese rural children
Authors: Guo Sijia , Cheung Chau Kiu Jacky , Hu Jieyi , Ning Xuan
Published: January 2021

Most studies equate children’s mental health to a state of flourishing, which is a positive feeling and functions in their lives. Identity exploration and the satisfaction of three basic psychological needs are universal and crucial indicators of children’s flourishing. First, according to identity crisis theory, children in the pre-adolescence period begin to explore their own identities, a process which significantly affects their development and flourishing. Meanwhile, self-determination theory points out that the basic psychological needs, namely the needs for autonomy, competence, and relatedness, are essential for children’s development and flourishing in the worldwide. Accordingly, this study examined how identity exploration affects the flourishing of rural children in China, one kind of collectivism cultural contexts, with the interaction effect of identity exploration and basic psychological needs satisfaction. To understand the interaction effect of identity exploration and basic psychological needs satisfaction on rural children’s flourishing, we form a theoretical framework combining identity crisis theory and self-determination theory. Both these two theories emphasize the importance of self in facilitating mental health and the development of functioning. Specifically, identity crisis theory focuses on intrapsychic process, while self-determination theory stresses the influence of the surrounding environment on the individual, which provides a solid foundation for integrating these two theories to explore rural children’s flourishing in China. Accordingly, this study collected 520 left-behind children and 475 other rural children in Liaoning Province in Mainland of China, and used regression analysis to measure the associations among variables. This study found that identity exploration and basic psychological needs satisfaction positively affect rural children’s flourishing respectively, while their interaction effects negatively affect on their flourishing.
The impact of predictability on dual-task performance and implications for resource-sharing accounts
Authors: Broeker Laura , Ewolds Harald , de Oliveira Rita F. , Künzell Stefan , Raab Markus
Published: January 2021

The aim of this study was to examine the impact of predictability on dual-task performance by systematically manipulating predictability in either one of two tasks, as well as between tasks. According to capacity-sharing accounts of multitasking, assuming a general pool of resources two tasks can draw upon, predictability should reduce the need for resources and allow more resources to be used by the other task. However, it is currently not well understood what drives resource-allocation policy in dual tasks and which resource allocation policies participants pursue. We used a continuous tracking task together with an audiomotor task and manipulated advance visual information about the tracking path in the first experiment and a sound sequence in the second experiments (2a/b). Results show that performance predominantly improved in the predictable task but not in the unpredictable task, suggesting that participants did not invest more resources into the unpredictable task. One possible explanation was that the re-investment of resources into another task requires some relationship between the tasks. Therefore, in the third experiment, we covaried the two tasks by having sounds 250 ms before turning points in the tracking curve. This enabled participants to improve performance in both tasks, suggesting that resources were shared better between tasks.
How a picture becomes a word: individual differences in the development of language-mediated visual search
Authors: Chabal Sarah , Hayakawa Sayuri , Marian Viorica
Published: January 2021

Over the course of our lifetimes, we accumulate extensive experience associating the things that we see with the words we have learned to describe them. As a result, adults engaged in a visual search task will often look at items with labels that share phonological features with the target object, demonstrating that language can become activated even in non-linguistic contexts. This highly interactive cognitive system is the culmination of our linguistic and visual experiences—and yet, our understanding of how the relationship between language and vision develops remains limited. The present study explores the developmental trajectory of language-mediated visual search by examining whether children can be distracted by linguistic competitors during a non-linguistic visual search task. Though less robust compared to what has been previously observed with adults, we find evidence of phonological competition in children as young as 8 years old. Furthermore, the extent of language activation is predicted by individual differences in linguistic, visual, and domain-general cognitive abilities, with the greatest phonological competition observed among children with strong language abilities combined with weaker visual memory and inhibitory control. We propose that linguistic expertise is fundamental to the development of language-mediated visual search, but that the rate and degree of automatic language activation depends on interactions among a broader network of cognitive abilities.
Improvement of the optical properties after surface error correction of aluminium mirror surfaces
Authors: Ulitschka M. , Bauer J. , Frost F. , Arnold T.
Published: January 2021

Ion beam finishing techniques of aluminium mirrors have a high potential to meet the increasing demands on applications of high-performance mirror devices for visible and ultraviolet spectral range. Reactively driven ion beam machining using oxygen and nitrogen gases enables the direct figure error correction up to 1 μm machining depth while preserving the initial roughness. However, the periodic turning mark structures, which result from preliminary device shaping by single-point diamond turning, often limit the applicability of mirror surfaces in the short-periodic spectral range. Ion beam planarization with the aid of a sacrificial layer is a promising process route for surface smoothing, resulting in successfully reduction of the turning mark structures. A combination with direct surface smoothing to perform a subsequent improvement of the microroughness is presented with a special focus on roughness evolution, chemical composition, and optical surface properties. As a result, an ion beam based process route is suggested, which allows almost to recover the reflective properties and an increased long-term stability of smoothed aluminium surfaces.
Cardiac function and cognitive function in patients with obstructive sleep apnea
Authors: Vahedi Ensieh , Khosravi Arezoo , Alizadian Rahman , Badri Taleb
Published: January 2021

Objectives

This study was designed to evaluate echocardiographic findings in patients with obstructive sleep apnea (OSA) with cognitive impairment and compare it with the control group.

Methods

Sixty-seven OSA patients and 52 group of healthy controls were evaluated prospectively by Mini-Mental State Examination questionnaire and trans-thoracic echocardiography.

Results

The cognitive impairment and diastolic dysfunction were 19.6% (P = .002) and 18.4% (P = .016) more prevalent in OSA group compared to the control group. The mean tricuspid regurgitant gradient, pulmonary artery size, and transmitral A velocity were higher, but mean right ventricular peak systolic velocity, tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), transmitral E/A ratio, and annular E’ velocity were lower in the OSA group than the control group. Comparing the patients with and without cognitive disorders, showed significant differences regarding the size of right atrium, TAPSE and FAC (P < .05).

Conclusions

OSA patients need accurate cardiac examinations, early diagnosis, and interventions to prevent the progression of cardiac dysfunction, especially older male patients with higher BMI and impaired cognition. Further studies are needed to determine the exact link between the OSA, obesity, and cardiac physiology.
Comparative analysis of the antioxidant capacity and lipid and protein oxidation of soy and oats beverages
Authors: Moretto Laura , Tonolo Federica , Folda Alessandra , Scalcon Valeria , Bindoli Alberto , Bellamio Marco , Feller Emiliano , Rigobello Maria Pia
Published: January 2021

Soy (Glycine max) and oats (Avena sativa) are plant sources used in milk-alternative beverages. However, protein and lipid constituents of these food matrices can undergo alterations during the storage. In this work, a commercial formulation of soy and oat-based beverages were comparatively evaluated. During the 12 months of shelf life and two following months, their phenolic content, antioxidant capacity, lipid peroxidation, protein carbonyl formation and protein breakdown were assessed. Total phenolic content and antioxidant capacity of soy and oat-based beverages were maintained during the entire period of 14 months. Both beverages did not show any increase in spontaneous lipid peroxidation beyond the basal level, however, due to the different content of unsaturated fats, when lipid peroxidation was stimulated, soy exhibited a major peroxidizability with respect to oat beverage. Oxidative alteration of proteins, estimated as carbonyl group formation, presented no increase with respect to the basal levels both in soy and oat beverages for all 14 months. Finally, soy proteins showed a gradual increase of proteolytic activity up until half of the shelf life, while oat did not show significant changes in protein fragmentation. In conclusion, both soy and oat beverages resulted oxidatively stable throughout their storage. We suggest that phytochemicals might guarantee the oxidative stability of the product, possibly in combination with antioxidant bioactive peptides, which already have well-known benefits on human health.

Graphical abstract
Neuroleptic malignant syndrome: clinical expression, complication, course, and atypical clinical picture
Authors: Oneib Bouchra , Zaimi Ouafae
Published: January 2021

Background

Neuroleptic malignant syndrome (NMS) is an uncommon and lethal side effect of neuroleptics. The clinical expression of this syndrome is diverse. Even with criteria diagnosis, it is hard to recognize it easily.

We report a series of 25 cases of NMS among patients hospitalized in psychiatric service at Oujda for 5 years. We have described the clinical characteristics of NMS in these patients, the treatments received, the management, and the course of this syndrome.

Results

Most of the patients are hospitalized for psychotic or affective disorders according to the Diagnostic and Statistical Manual of Mental Disorders (DSM V) criteria. 92% of patients received conventional neuroleptic, and half of them were under the injectable form. No patient took long-acting injectable antipsychotics. 36% of patients received neuroleptics for the first time. NMS appeared in the first week after the admission in psychiatric service among 24 patients. The most common clinical and biological signs were muscular rigidity, the elevation of creatine phosphokinase (CPK), and alteration of blood pressure. Other symptoms were found in proportion varied between 24% and 72%. 32% of the patients did not develop complications. One patient developed renal failure. All patients recovered, and no deaths were recorded.

Conclusions

Early recognition of NMS help to rescue patient. It is necessary to detect this syndrome even in the absence of main signs such as fever.
Beyond the Sun
Authors: Starosielski Nicole
Published: January 2021

This article tracks solarity beyond the sun. It documents what the author calls embedded solarities, the manifestations of being solar in social practice, infrastructural assemblages, and human and non-human life. Focusing on two cases of mediating sunlight in agricultural practice—the management of chickens’ reproductive cycles and the negotiation of shade for agricultural laborers—the article dismantles the classical solar subject, who simply receives the sun’s rays as a gift. Instead of assuming that solar reception simply produces growth, this article proposes that sunlight can be accessed only through mediation. Moreover, it can be weaponized through architectural and social formations as easily as it can be made beneficial. In place of a model that privileges the sun as the source of generous radiance and humans as its primary recipients, an attunement to embedded solarities directs attention to the solar resources, effects, and affects latent in the environment. In particular, it directs us to the phenomenon of radiant life—the ways that life not only is sustained through the ongoing management of solar radiance, but also is itself materialized as radiant, entangled in a field of spectral exchange.