bluuebunny/crossref_metadata_2025 huggingface dataset:
Myopathologic trajectory in Duchenne muscular dystrophy (DMD) reveals lack of regeneration due to senescence in satellite cells
Authors: Cardone Nastasia , Taglietti Valentina , Baratto Serena , Kefi Kaouthar , Periou Baptiste , Gitiaux Ciryl , Barnerias Christine , Lafuste Peggy , Pharm France Leturcq , Pharm Juliette Nectoux , Panicucci Chiara , Desguerre Isabelle , Bruno Claudio , Authier François-Jerome , Fiorillo Chiara , Relaix Frederic , Malfatti Edoardo
Published: October 2023

Duchenne muscular dystrophy (DMD) is a devastating X-linked muscular disease, caused by mutations in the DMD gene encoding Dystrophin and affecting 1:5000 boys worldwide. Lack of Dystrophin leads to progressive muscle wasting and degeneration resulting in cardiorespiratory failure. Despite the absence of a definitive cure, innovative therapeutic avenues are emerging. Myopathologic studies are important to further understand the biological mechanisms of the disease and to identify histopathologic benchmarks for clinical evaluations. We conducted a myopathologic analysis on twenty-four muscle biopsies from DMD patients, with particular emphasis on regeneration, fibro-adipogenic progenitors and muscle stem cells behavior. We describe an increase in content of fibro-adipogenic progenitors, central orchestrators of fibrotic progression and lipid deposition, concurrently with a decline in muscle regenerative capacity. This regenerative impairment strongly correlates with compromised activation and expansion of muscle stem cells. Furthermore, our study uncovers an early acquisition of a senescence phenotype by DMD-afflicted muscle stem cells. Here we describe the myopathologic trajectory intrinsic to DMD and establish muscle stem cell senescence as a pivotal readout for future therapeutic interventions.
Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
Authors: Yukawa Kayo , Yamamoto-Mcguire Satomi , Cafaro Louis , Hong Christine , Kamme Fredrik , Ikezu Tsuneya , Ikezu Seiko
Published: October 2023

Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau pathology evolves in Alzheimer’s disease (AD). The protein expression level of TTBK1 is elevated in the cortex brain tissues with AD patients compared to the control subjects. We therefore hypothesized that antisense oligonucleotide (ASO) based targeting Ttbk1 could prevent the accumulation of phosphorylated tau, thereby delaying the development of tau pathology in AD. Here we show that in vivo administration of ASO targeting mouse Ttbk1 (ASO-Ttbk1) specifically suppressed the expression of Ttbk1 without affecting Ttbk2 expression in the temporal cortex of PS19 tau transgenic mice. Central administration of ASO-Ttbk1 in PS19 mice significantly reduced the expression level of representative phosphor-tau epitopes relevant to AD at 8 weeks post-dose, including pT231, pT181, and pS396 in the sarkosyl soluble and insoluble fractions isolated from hippocampal tissues as determined by ELISA and pS422 in soluble fractions as determined by western blotting. Immunofluorescence demonstrated that ASO-Ttbk1 significantly reduced pS422 phosphorylated tau intensity in mossy fibers region of the dentate gyrus in PS19 mice. RNA-sequence analysis of the temporal cortex tissue revealed significant enrichment of interferon-gamma and complement pathways and increased expression of antigen presenting molecules (Cd86, Cd74, and H2-Aa) in PS19 mice treated with ASO-Ttbk1, suggesting its potential effect on microglial phenotype although neurotoxic effect was absent. These data suggest that TTBK1 is an attractive therapeutic target to suppress TTBK1 without compromising TTBK2 expression and pathological tau phosphorylation in the early stages of AD.
Concordance between head and neck MRI and histopathology in detecting laryngeal subsite invasion among patients with laryngeal cancer
Authors: Mohamad Issa , Hejleh Taher Abu , Qandeel Monther , Al-Hussaini Maysa , Koro Sami , Taqash Ayat , Almousa Abdelatif , Abuhijla Fawzi , Abuhijlih Ramiz , Ajlouni Fatenah , Al-Ibraheem Akram , Laban Dima Abu , Hussein Tariq , Mayta Ebrahim , Al-Gargaz Wisam , Hosni Ali
Published: October 2023

Background

Accuracy of head and neck MRI (HN-MRI) in predicting tumor invasion of laryngeal site/subsites in patients with laryngeal cancer prior to laryngectomy is poorly evaluated in the literature. Therefore, we aim to evaluate the diagnostic value of HN-MRI in accurate pre-operative estimation of tumor invasion to laryngeal subsites in patients with laryngeal cancer.

Methods

Patients with laryngeal cancer who underwent HN-MRI for cancer staging and underwent total laryngectomy between 2008 and 2021 were included. Sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of HN-MRI in predicting tumor invasion of laryngeal subsites were calculated based on concordance between the HN-MRI and histopathological results.

Results

One hundred and thirty-seven patients underwent total laryngectomy [primary: 82/137(60%), salvage 55/137(40%)]. The utilization of HN-MRI resulted in the downstaging of 16/137 (11.6%) patients and the upstaging of 8/137 (5.8%) patients. For the whole cohort, there was a significant discordance between HN-MRI and histopathology for T-category; out of 116 cT4a disease, 102(87.9%) were confirmed to have pT4a disease, and out of 17 cT3 disease, 9(52.9%) were confirmed to have pT3 disease, p < 0.001. The MRI overall diagnostic accuracy of predicting tumor invasion was 91%, 92%, 82%, 87%, 72%, 76%, 65% and 68% for base of tongue, arytenoid, vocal cord, posterior commissure, pre-epiglottic space, cricoid cartilage, inner thyroid cortex, and subglottis, respectively.

Conclusions

In patients with laryngeal cancer undergoing total laryngectomy, HN-MRI demonstrates promising accuracy in predicting tumor invasion of specific laryngeal subsites (e.g., base of tongue). Our findings showed the potential of HN-MRI as a valuable tool for pre-operative planning and treatment decision-making in this patient population.
Effects of combined application of benzoic acid and 1-monolaurin on growth performance, nutrient digestibility, gut microbiome and inflammatory factor levels in weaned piglets
Authors: Wei Kai , Yang Xia , Zhao Huasheng , Chen Huanchun , Bei Weicheng
Published: October 2023

Background

Our previous study observed that benzoic acid and 1-monolaurin have a synergistic bactericidal effect. Moreover, their improvement effect of benzoic acid and 1-monolaurin on the growth performance and diarrhea of weaned piglets was better than the two feedings alone. However, it is not clear how the combination of benzoic acid and 1-monolaurin affects the growth performance of weaned piglets. Therefore, 100 weaned piglets (mean weight 7.03 ± 1.04 kg, mean weaning age 26 d) were randomly divided into two groups: (1) basal diet control (CON); (2) basal diet supplemented with 0.6% benzoic acid and 0.1% 1-monolaurin (CA). The experiment lasted 28 days after weaning. The effects of benzoic acid and 1-monolaurin supplementation on growth performance, apparent nutrient digestibility, intestinal flora composition and function, and inflammatory factor levels of weaned piglets were investigated.

Results

The feed conversion efficiency of piglets in the CA group between 15 and 28 d and 1 and 28 d after weaning was significantly higher than that in the CON group (P < 0.05). Additionally, the diarrhea proportion and frequency of piglets in the CA group 1–14 days post-weaning were significantly decreased (P < 0.05). The apparent digestibility of dry matter, organic matter and crude protein of piglets in the CA group was significantly higher than the CON group on days 14 and 28 (P < 0.05). The microbial composition in the cecal digesta of piglets was detected. The results indicated that the CA group piglets were significantly supplemented with g_YRC22 at day 14 and g_Treponema, g_Pseudomonas, and g_Lachnobacterium at day 28 (P < 0.05; log LDA > 2). No significant difference was observed between the CON and CA groups in the content of short-chain fatty acids. In addition, serum IL−1β level significantly decreased at day 28 in the CA group compared with the CON group, while serum endotoxin content was significantly reduced at day 14.

Conclusion

Therefore, dietary supplementation of 0.6% benzoic acid and 0.1% 1-monolaurin enhanced growth performance and nutrient digestibility, affected gut microflora composition, and decreased systemic inflammatory response and intestinal permeability of weaned piglets. These outcomes provide a theoretical basis for applying of benzoic acid and 1-monolaurin over weaned piglets.
Cognitive performance outcomes: considerations for drug development
Authors: Zupan Zorana
Published: October 2023

Ensuring that cognitive assessments are fit for purpose is critical in the evaluation of the clinical benefit of new therapeutic interventions. Although guidelines for Clinical Outcome Assessments (COA) are available, performance outcome (PerfO) assessments, and in particular those assessing cognition (Cog-PerfOs) are more complex and have additional requirements that need to be considered. I outline three areas where further discussion around validation methods for Cog-PerfOs and best practices is warranted: (1) content validity (2) ecological validity, and (3) construct validity in multinational contexts. I conclude with a discussion of several potential avenues for the improvement of validation of Cog-PerfOs used to evaluate the efficacy of medical products that target cognitive symptomatology. These include the involvement of cognitive psychologists in establishing content validity of Cog-PerfOs, evaluating the congruence of laypeople’s and expert understanding of cognitive concepts, supplementing qualitative with quantitative evidence when establishing content validity, demonstrating ecological validity, and ensuring normative data are available in multinational contexts.
AI temporal planning for energy smart buildings
Authors: Georgievski Ilche , Shahid Muhammad Zamik , Aiello Marco
Published: October 2023

Buildings are responsible for about one-third of industrialised countries’ overall energy consumption and greenhouse gas emissions. As if this was not enough, recently, energy prices significantly increased and affected all economic areas. Making buildings more efficient and effective is the step needed toward cost reductions. Key enablers of cost-effectiveness are leveraging batteries, awareness of and adaptability to energy prices, and integrating powerful reasoning techniques to optimally and flexibly operate buildings. Researchers have tackled many of these aspects using a variety of approaches. Whereas a less investigated one is that of AI planning to coordinate actions and save energy in buildings. However, generating plans based on signals of energy prices and leveraging batteries is still an open research problem. To address this high-potential aspect, we engineer an AI planning system for improving the energy-cost effectiveness in buildings by coordinating the building’s operation based on day-ahead prices and the use of a battery, all without sacrificing the comfort of building occupants. We propose to exploit temporal planning due to its powerful modelling and reasoning features, especially in explicitly addressing time. We evaluate the effectiveness of the system in several scenarios with varying building environmental conditions. We compare the energy cost from using our planning system to a baseline cost, where we record a reduction of 43rage in favour of our system.
Quantum–classical co-simulation for smart grids: a proof-of-concept study on feasibility and obstacles
Authors: Vereno Dominik , Khodaei Amin , Neureiter Christian , Lehnhoff Sebastian
Published: October 2023

With the rising complexity of our electricity infrastructure, smart grid simulations increasingly rely on co-simulation, which involves jointly executing independent subsystem simulations. However, in large-scale simulation scenarios, such as those involving costly power-flow analysis, co-simulation may experience computational-performance issues. Quantum computing offers a potential solution through quantum–classical co-simulation, in which one or more simulators of an otherwise classical co-simulation are executed on quantum hardware. However, there is no practical realization of this concept that establishes its feasibility. To address this gap, we integrate a quantum power flow simulator with a smart grid co-simulation and conduct an exploratory simulation study using a fictitious case-study scenario. The experiments demonstrate the feasibility of quantum–classical co-simulation; at the same time, they highlight four obstacles to the concept’s realization in practice: (1) To use quantum computing for co-simulation, session-based scheduling is required. (2) Distributed simulation limits possible applications and requires proximity of computing resources. (3) For the efficient extraction of classical information from the quantum states, we need carefully designed operators. (4) Current hardware limitations—such as noise susceptibility and the lack of quantum random access memory—limit practical near-term uses of quantum power flow; therefore, attention should be turned to alternative applications that are more promising in the near term. These findings pave the way for future research on quantum–classical co-simulation and its potential applications in smart grids.
INTERCEPT H3: a multicenter phase I peptide vaccine trial for the treatment of H3-mutated diffuse midline gliomas
Authors: Grassl Niklas , Sahm Katharina , Süße Heike , Poschke Isabel , Bunse Lukas , Bunse Theresa , Boschert Tamara , Mildenberger Iris , Rupp Anne-Kathleen , Ewinger Max Philipp , Lanz Lisa-Marie , Denk Monika , Tabatabai Ghazaleh , Ronellenfitsch Michael W. , Herrlinger Ulrich , Glas Martin , Krex Dietmar , Vajkoczy Peter , Wick Antje , Harting Inga , Sahm Felix , von Deimling Andreas , Bendszus Martin , Wick Wolfgang , Platten Michael
Published: October 2023

Introduction

Diffuse midline gliomas (DMG) are universally lethal central nervous system tumors that carry almost unanimously the clonal driver mutation histone-3 K27M (H3K27M). The single amino acid substitution of lysine to methionine harbors a neoantigen that is presented in tumor tissue. The long peptide vaccine H3K27M-vac targeting this major histocompatibility complex class II (MHC class II)-restricted neoantigen induces mutation-specific immune responses that suppress the growth of H3K27M+ flank tumors in an MHC-humanized rodent model.

Methods

INTERCEPT H3 is a non-controlled open label, single arm, multicenter national phase 1 trial to assess safety, tolerability and immunogenicity of H3K27M-vac in combination with standard radiotherapy and the immune checkpoint inhibitor atezolizumab (ATE). 15 adult patients with newly diagnosed K27M-mutant histone-3.1 (H3.1K27M) or histone-3.3 (H3.3K27M) DMG will be enrolled in this trial. The 27mer peptide vaccine H3K27M-vac will be administered concomitantly to standard radiotherapy (RT) followed by combinatorial treatment with the programmed death‐ligand 1 (PD-L1) targeting antibody ATE. The first three vaccines will be administered bi-weekly (q2w) followed by a dose at the beginning of recovery after RT and six-weekly administrations of doses 5 to 11 thereafter. In a safety lead-in, the first three patients (pts. 1–3) will be enrolled sequentially.

Perspective

H3K27M-vac is a neoepitope targeting long peptide vaccine derived from the clonal driver mutation H3K27M in DMG. The INTERCEPT H3 trial aims at demonstrating (1) safety and (2) immunogenicity of repeated fixed dose vaccinations of H3K27M-vac administered with RT and ATE in adult patients with newly diagnosed H3K27M-mutant DMG.

Trial registration

NCT04808245.
Early onset Caroli’s disease with associated renal cystic disease presented with recurrent fever and epigastric pain: a case report
Authors: Mishra Abhishek , Mallick Achinta Kumar , Singh A. K. , Mishra Anushree
Published: October 2023

Background

Caroli’s disease is characterized by non-obstructive dilatation of intrahepatic biliary radicals with formation of calculi followed by recurrent episodes of cholangitis. It is a rare congenital malformation and often remains silent, diagnosed accidentally. But if kept unattended, and without any early intervention, it may lead to fatal residual complications. Hence, its early recognition is of utmost importance to prevent recurrent cholangitis, hepatic abscess, liver cirrhosis and cholangiocarcinoma. Hence, we feel that this case must be reported so as to increase awareness among physicians regarding this entity.

Case presentation

We hereby report a case of 10-year-old boy who reported with complaints of recurrent episodes of fever, breathing difficulty and multiple episodes of epigastric abdominal pain with apparently healthy siblings. His routine investigation, laboratory parameters were within normal limits. Ultrasonography abdomen showed liver with normal echo-texture with varying sized multiple thin walled cysts involving both the lobes, right more than left with saccular dilatation of 2nd and 3rd order intra-hepatic biliary radicals without calcification without any colour flow on Doppler evaluation. The common hepatic and common bile ducts were normal in calibre and lumen. Magnetic resonance imaging abdomen had similar findings and upper GI endoscopy was also normal. He was finally diagnosed to be a case of Caroli’s disease and was managed with broad spectrum antibiotics, ursodeoxycholic acid, multivitamins, and calcium supplements. He made an uneventful recovery thereafter. Parents were counselled about the risk of cholangitis and cholangiocarcinoma and was referred to tertiary care centre for genetic counselling and for future need of liver transplantation.

Conclusion

Age presentation of Caroli’s disease varies. Majority present during adolescence and early adulthood. This often poses a diagnostic challenge owing its rare entity and silent presentation. A strong index of suspicion and prompt diagnosis is warranted to prevent its fatal residual complications.
Characteristics of low back pain and its associated factors among healthcare providers at a tertiary hospital in Sylhet city: a cross-sectional study
Authors: Islam Mohammad Jahirul , Ahmed Sohel , Islam Khandaker Md Kamrul , Al Mamun Muhammad Abdullah , Roy Shankar Kumar , Chakraborty Shishir Ranjan
Published: October 2023

Background

Healthcare providers serve as the backbone of the healthcare system, yet they frequently have low back pain (LBP) due to ergonomic factors. Therefore, the objective of this research was to identify the characteristics of LBP and its associated factors among healthcare providers in Bangladesh.

Methodology

In this cross-sectional study, 310 medical providers, both male and female, participated. An interviewer-administered questionnaire was used to evaluate data regarding different measures of LBP. The chi-square test and descriptive statistics were used to evaluate the data. To identify the predicted risk factor for LBP, binary logistic regression was performed.

Result

A total of 51.9% of healthcare providers reported having LBP at least once a day in the past 12 months, 25.8% had chronic LBP, 18.1% had to take time off work due to LBP, and 57.89% had received combination medication and physiotherapy in the previous 12 months. The advanced age (41–59 years) adjusted odds ratio (AOR) = 1.83, 95% confidence interval (CI) = 1.04–3.22; p = 0.034), lifting objects (AOR = 2.00, 95% CI = 1.06–3.78; p = 0.032), awkward position (AOR = 6.54, 95% CI = 3.04–14.10; p = 0.001), physical exercise (AOR = 3.81, 95% CI = 2.23–6.52; p = 0.001), and comorbidities (AOR = 1.79, 95% CI = 1.00–3.20) were predictors for developing LBP at least once in the past 12 months.

Conclusion

According to this study, more than half of healthcare professionals reported having LBP at least once in the previous 12 months. Good working posture, ergonomic knowledge, and safe lifting techniques are essential to getting rid of this problem. In addition, good medical attention and regular exercise are required.
Brain-derived neurotrophic factor is associated with cardiometabolic risk factors in HIV patients on combination antiretroviral therapy in Ghana
Authors: Yeboah Kwame , Otu Francys Frimpong , Agyekum Jennifer Adjepong , Dzudzor Bartholomew
Published: October 2023

Background

Brain-derived neurotrophic factor (BDNF) has been implicated in the development of cardiometabolic risk factors in some populations. However, few studies have investigated the role of BDNF and cardiometabolic risk factors in HIV patients despite the plethora of evidence linking HIV infection with the dysregulation of circulating BDNF levels. We investigated the association between serum BDNF and cardiometabolic risk factors in HIV patients in a primary hospital in Ghana. We recruited 450 participants, comprising 150 combination antiretroviral (cART)-treated HIV patients, 150 cART-naïve HIV patients, and 150 non-HIV controls. Data on sociodemographic parameters and medical history were collected using a structured questionnaire. Fasting venous blood samples were collected to measure plasma glucose levels, lipid profiles, and BDNF. Metabolic syndrome (MetS) was defined using the joint interim statement criteria.

Results

Compared to untreated HIV patients and uninfected controls, the proportion of participants having MetS was high in cART-exposed HIV patients (26.8% vs 21.1% vs 52.1%, respectively, p < 0.001). Generally, BDNF levels were higher in uninfected controls compared with untreated and cART-exposed HIV patients [7.1 (3.4–13.3) vs 4.9 (2.7–9.6) vs 5.6 (2.9–8.9) ng/ml, p = 0.025]. In participants without MetS, square root-transformed serum BDNF was lowest in cART-exposed HIV patients, followed by untreated HIV patients, with uninfected controls having the highest (1.8 ± 0.8 vs 2.4 ± 1.2 vs 2.9 ± 1.2 ng/ml, p < 0.001). MetS was associated with serum BDNF levels in only the cART-exposed HIV patients [OR (95% CI) = 2.98 (1.64–5.41), p < 0.001]. In cART-exposed HIV patients, an increase in BDNF was associated with increased likelihood of having impaired fasting glucose [2.49 (1.51–4.11), p < 0.001], high systolic blood pressure [1.64 (1.1–2.46), p = 0.016], and hypertriglyceridemia [2.73 (1.65–4.52), p < 0.001], as well as decreased likelihood of having low HDL cholesterol levels [0.32 (0.19–0.56), p < 0.001].

Conclusion

In our study population, MetS was higher in cART-exposed HIV patients. HIV patients have low levels of serum BDNF, especially those without MetS. BDNF was associated with MetS and its components in HIV patients on cART management.
Unexpected Durable Complete Response With Anti–PD-L1 Blockade in Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report With Host and Tumor Biomarker Analysis
Authors: Pesántez David , Indacochea Alberto , Angelats Laura , Sirico Marianna , Victoria Iván , Sanfeliu Esther , Teixido Cristina , González-Navarro Azucena E. , Galván Patricia , Brasó-Maristany Fara , Jares Pedro , Juan Manel , Prat Aleix , Schettini Francesco , García-Corbacho Javier
Published: October 2023

We extensively characterized a metastatic UPS with a 71-month lasting complete response to immunotherapy.
A Moonless Night
Authors: Suess Solveig Qu
Published: October 2023

Curated Spaces features the work of artist and filmmaker Solveig Qu Suess. This essay provides narrative and visual context for her film Little Grass. The film explores the history of geopolitical division between China and the West through the lens of her mother’s career as an optical engineer, expelled from the Chinese state in 1987 for marrying a Western colleague. “A Moonless Night” offers a reflection on memory, belonging, Cold War politics, and state power.
Demystification and feasibility of CRISPR technology and gene editing in African laboratories
Authors: Jemaà Mohamed
Published: October 2023

Clustered regularly interspaced short palindromic repeats, or CRISPR, is a powerful molecular biology tool that is enabling high-quality genetic research and engineering. However, for practical reasons, but more specifically because of the lack of training and the rapid development of gene-editing technology, the technique is still not well established in African laboratories. For this reason, a consortium formed by the Institut Pasteur of Tunis and Learn and Win decided to organise an international conference and workshop on CRISPR technology in particular and gene editing in general, focusing on the low-budget model more appropriate to the African context. From 12 to 17 June 2023, more than 200 interdisciplinary researchers and students from the life sciences and more than 20 international speakers and trainers gathered at the Institut Pasteur in Tunis, Tunisia, for the First African Conference and Workshop on CRISPR to discuss the latest gene editing technologies and discoveries. This Meeting Review describes the scientific event and highlights the main outcomes of both the conferences and the practical sessions. The symposium was a real success and thrives to educate, train and network international and young scientists in the field of gene editing and gene engineering.
Auditor Tenure and Misreporting: Evidence from a Dynamic Oligopoly Game
Authors: Cheynel Edwige , Zhou Frank S.
Published: October 2023

We estimate an infinite-horizon dynamic oligopoly model of audit firm tenure and misstatements and evaluate a policy counterfactual involving mandatory audit firm rotation. Longer tenure lowers the cost of producing audits, increasing audit quality and reducing audit fees. Thus clients are less likely to misstate and more likely to keep the incumbent audit firm as tenure increases. By reducing the value of retaining audit firms, mandatory rotation leads to large increases in auditor switches, even before the term limit, implying increases in the switching costs borne by clients. Misstatement rates increase because audit firms endogenously lower audit quality and newly hired audit firms have lower quality. Overall, the model suggests caution when evaluating the costs and benefits of government oversight over the audit profession.

This paper was accepted by Suraj Srinivasan, accounting.

Funding: The authors thank the financial support from the Olin Busiiness School and the Wharton School of the University of Pennsylvania.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.4944 .
O lugar da Instalação Literária na Literatura Brasileira Contemporânea
Authors: Santos Carolina Barbosa Lima e , Moraes Paulo Eduardo Benites de
Published: October 2023

As práticas estéticas contemporâneas têm sido marcadas, com um aumento cada vez mais significativo, por aquilo que Florencia Garramuño denomina como “instabilidade” na configuração de suas respectivas produções. No âmbito literário, este aspecto instável advém de fatores como a expansão da literatura e seus respectivos deslocamentos poéticos, estimulados pela convivência destes textos com arquivos de toda sorte, tais como fotografias, apropriação e colagem de elementos de outras obras, além de manipulações gráficas e tipográficas em suas construções discursivas. Este processo crescente de fixação de imagens e outras formas de visualidade na página impressa cedem lugar para pensarmos sobre o conceito de instalação, comumente utilizado no campo das Artes Visuais, nas obras literárias, bem como refletirmos sobre o papel do escritor diante dessas manipulações intermidiáticas para a composição de suas respectivas proposições artísticas. Partindo desta perspectiva interartística, este artigo busca mapear, a partir das obras de Luiz Ruffato, Verônica Stigger e André Vallias, as condições de emergência da expansão literária no âmbito da literatura contemporânea brasileira.
Achados Intermidiáticos na Literatura Eletrônica de Wattpad
Authors: Da Silva Gramiani Celeste Jennifer , De Souza Sérgio Ferreira Rogério
Published: October 2023

Este artigo almeja apresentar investigações no campo de intersecção entre Estudos Literários e Interartes. Para isso, parte de alguns dos principais registros presentes em uma tese de doutoramento já defendida na área de Literatura. A pesquisa objetivou dissertar a respeito das perspectivas em relação à manifestação literária de cunho eletrônico, em especial, aquela produzida em Wattpad, uma plataforma virtual de autopublicação. Neste texto, o foco se debruça sobre a obra Aika, assinada por Lúcia Lemos, uma wattpader brasileira. Os livros dessa autora são exemplos da arte que possui caráter intermidiático, pois neles diferentes mídias se convergem, criando resultados ímpares. Em função do caminho trilhado, os aportes teóricos de alguns estudiosos se fizeram necessários, tal como é o caso de Vilém Flusser, Claus Clüver, João Maria Mendes e Irina Rajewsky. Em geral, percebemos que a Literatura Eletrônica têm logrado conquistar espaço dentre as muitas formas de ser, estar e existir do texto quando em tempos contemporâneos e digitais, sobretudo se sob a tenda da intermidialidade.Palavras-chave: Literatura eletrônica. Intermidialidade. Autoria independente. Wattpad.
Representação de mídia e transmidiação em quadrinhos: o caso de Sabrina, de Nick Drnaso
Authors: Augusta Pires de Figueiredo Camila
Published: October 2023

Nos estudos de intermidialidade, os processos de representação de mídia e de transmidiação tratam da maneira como certas características midiáticas são transformadas ao serem transferidas de uma determinada mídia a outra. A análise desses fenômenos envolvendo determinado tipo de mídia qualificada ou de produtos de mídia específicos segundo Lars Elleström (2014; 2017; 2021) pode ajudar a identificar as formas pelas quais essas mídias comunicam informações específicas e com que finalidade. Neste trabalho pretendo examinar as estratégias de representação de mídia e de transmidiação em quadrinhos, tomando como exemplo o caso de Sabrina, de Nick Drnaso, primeira graphic novel a ser indicada ao prêmio literário Man Booker Prize. Meu objetivo é refletir sobre a função comunicacional de tais fenômenos midiáticos na obra, buscando entender como esses tipos de transformação de mídia atuam nos processos de significação. A partir de alguns exemplos de Sabrina, aponto como tais fenômenos afetam a maneira como interpretamos os eventos narrativos, em especial as notícias que reverberam o assassinato da personagem que dá nome ao livro.
Uma abordagem intermidiática: lendo imgens e tipos em Dom Pantero, de Ariano Suassuna
Authors: Malafaia Rosana da Silva
Published: October 2023

O presente artigo possui como tema o estudo das imagens e dos tipos gráficos no Romance de Dom Pantero no palco dos pecadores, de Ariano Suassuna. Seu principal objetivo foi investigar as relações intermidiáticas provocadas a partir da leitura dos desenhos e das letras que compõem a narrativa. Ao inserir na tessitura do enredo mídias imagéticas, o autor produz efeitos de sentidos que ultrapassam o sentido hermenêutico. A análise dessas mídias interfere na construção de sentidos da narrativa, além de permitir que o leitor conecte linguagens sem hierarquizações. Diante de tamanha complexidade, este artigo buscou realizar esta investigação amparado nos seguintes pesquisadores da área: Clauss Clüver (2006; 2011) e Irina Rajewsky (2012) embasaram as reflexões relativas às artes enquanto mídias e à categorização das mídias, respectivamente; Maria Cristina Ribas (2007; 2018), no que tange a Intermidialidade como método de análise da obra; Alex Martoni (2020) e Gumbrecht (2010) no resgate aos efeitos de presença produzidos, quando o escritor faz referência à determinada mídia na tessitura do romance. As reflexões obtidas demonstraram como os estudos sobre Intermidialidade ampliam o sentido da obra, oferecendo ao leitor diferentes modos de ler e compreender o texto.
(Co)creando contextos participativos, representativos y colaborativos: concretizaciones del trabajo en equipo democratizador en y desde el trabajo social ultramoderno.
Authors: Curbelo Hernández Emiliano A.
Published: October 2023

El trabajo en equipo democratizador en y desde el Trabajo Social ultramoderno supone una novedosa visión que, en parte, incluye y conecta con algunos elementos de la actual definición del Trabajo Social a nivel global, es así como, aplicados en y desde el marco de los equipos de trabajo, ensalzan planteamientos participativos, representativos y colaborativos. Más allá de lo que se desarrolla en y desde el Trabajo Social tradicional, supone transitar a nuevas perspectivas ultramodernas que priorizan la diversidad entre y de lo técnico-profesional con el mundo de la afectividad y la emocionalidad, intentado asignar mayor protagonismo, no solamente a los profesionales, sino a las personas perceptoras de una ayuda profesionalizada. De análisis de las concretizaciones del enfoque del trabajo en equipo democratizador, vista desde nuestra disciplina, trata el presente manuscrito.
Elaboración de estados de la cuestión utilizando el recurso de las bases de datos. hacia la intervención para personas sordas desde el trabajo social, una revisión de publicaciones
Authors: Murcia Albañil Diana Marcela , Fernández Mostaza, María Esther
Published: October 2023

El debate actual sobre los protocolos de intervención para las personas sordas y la fusión de las líneas epistemológicas en la intervención de Trabajo Social, agrega complejidad a las discusiones relacionadas con el enfoque diferencial y la diversidad de las subjetividades sordas. En este trabajo se presentan los hallazgos en el estado de la cuestión y de manera general el análisis de las taxonomías discursivas de las perspectivas sobre la cultura sorda en clave de secuencia histórica. A partir de estos hallazgos se reflexiona sobre la manera de producir cono-cimiento desde la búsqueda en bases de datos y las posibles dificultades emergentes de esta tarea. Para concluir, el escrito llama la atención sobre la necesidad de generar más estudios que conecten las investigaciones recientes en torno a las subjetividades sordas desde lo empírico en conexión con producciones teóricas de circulación en bases de datos.
Los grupos multifamiliares en la rehabilitación psicosocial de personas con trastorno mental desde la mirada del Trabajo Social con grupos
Authors: Manchado Flores Miguel Ángel
Published: October 2023

Aproximación teórica mediante revisión bibliográfica a los Grupos Multifamiliares (GMF) como una de las actuales intervenciones familiares desarrolladas en centros diurnos no residenciales de rehabilitación psicosocial para personas con trastorno mental grave (TMG) de la Comunidad Autónoma de Madrid (CAM) incidiendo sobre las bases teóricas del modelo de Terapia Interfamiliar (TIF) y desde la perspectiva del Trabajo Social con Grupos. Se revisa mediante encuesta la presencia y características generales de Grupos Multifamiliares en una muestra de 63 dispositivos entre Centros de Rehabilitación Psicosocial (CRPS), Centros de Rehabilitación Laboral (CRL) y Centros de Día (CD) de la Red de Atención Social a Personas con Enfermedad Mental grave y duradera de la CAM.
Introduction: A Key Text for the Early Americas
Authors: Lamas Carmen E.
Published: October 2023

Abstract: For almost two centuries, the author and the editors of the first historical novel in Spanish published in the Americas, Jicotencal , remained unnamed. On the basis of documentary evidence, this symposium identifies the author as Cayetano Lanuza, and the true editors of the book as the New York firm of Lanuza, Mendía & Co.
Commentary on "Circumcision"
Authors: Kogan Claudio J.
Published: October 2023

Abstract: This commentary draws upon the author's experience in bioethics and as a physician, ordained Rabbi, and certified Mohel (a Jewish professional qualified to perform infant male circumcisions (MC)). People's identity and adherence to a religious belief are frequently cited reasons for deciding whether to circumcise their male children. For Jewish and Muslim males, circumcision is considered essential. In this commentary, the author uses his medical, religious, and bioethical knowledge, expertise, and experience to address common arguments used in opposing nontherapeutic male circumcision of minors. In these narratives, half of the parents agreed with circumcision, and half did not. The parents against circumcision cite human rights violations, security, privacy, and bodily integrity issues and refer to circumcision as genital mutilation, while those who agree argue that circumcision should be done for religious reasons to prevent health issues, promote hygiene and cleanness, avoid cancer, or for later sexual enjoyment. After evaluating the evidence, the author states that parents should be free to either consent or decline MC for a son. Though a reoccurring theme in these narratives was for mothers to leave the circumcision decision up to their male partners, the author concludes that women have considerable power regarding the decision.
Perspective féminine sur la dictature dans Femmes au temps des carnassiers de Marie-Célie Agnant
Authors: Jurney Florence Ramond
Published: October 2023

Abstract: Perspective féminine sur la dictature de Duvalier, le dernier roman de Marie-Célie Agnant met en scène la dictature et comment le traumatisme qui y est lié s'insère dans le présent des générations suivantes et le hante. C'est sous le signe de l'échange et des conversations partagées qu'a lieu cette négociation de souvenirs. Plusieurs types d'échanges prennent place dans ce roman de Marie-Célie Agnant et ce sont ces moments qui guideront cet article. Tout d'abord, la mise en parallèle des voix de deux femmes d'une même généalogie mais de différentes générations : si l'une se bat pour continuer à faire entendre sa voix dès les débuts de la dictature, l'autre s'acharne à exposer le traumatisme utilisé pour renforcer une mise au silence automatique. Ensuite, les échanges entre diverses femmes visant à soutenir les deux protagonistes : visites de courtoisie, "othermothering," amitiés entre femmes, toutes mettent en exergue ce qui rapproche ces femmes. Enfin, ce sont les différentes incursions du traumatisme dans le présent et ses représentations qui sont au centre de cette dernière partie : l'art (écriture de Junon, peinture de Soledad) a-t-il une place dans la reconstruction du moi après les débordements de la dictature ? La vengeance a-t-elle une place dans cette conversation, et si oui, laquelle et à quelles fins ?
"Elle ne me quitte pas": Isabelle Eberhardt and Language in Leïla Sebbar's Lettre à mon père
Authors: Goellner Sage
Published: October 2023

Abstract: This article analyzes Leïla Sebbar's interest in and representation of Isabelle Eberhardt, who crisscrosses Sebbar's texts as an imaginary precursor who possesses many of Sebbar's own contradictions and aspirations. This essay examines how Sebbar uses the figure of Eberhardt in exploration of her Franco-Algerian linguistic and cultural identity. Drawing principally from three works, Lettres parisiennes : autopsie d'un exil (1986), "Isabelle l'Algérien" (1988), and Lettre à mon père (2021), the author argues that Sebbar's depiction of Eberhardt as a multilingual French and Arabic speaker connects the two sides of Sebbar's divided identity. In addition, Sebbar's emphasis on the fact that both women write and publish in French underscores the powerful link between them. In these works, Eberhardt acts as a cipher for Sebbar and remains a touchstone of Sebbar's reflections upon identity, language, and reconciliation.
Hand acupuncture point localization method based on a dual-attention mechanism and cascade network model
Authors: Wang Hao , Liu Li , Wang Ying , Du Senhao
Published: October 2023

Deep learning techniques have, to a certain extent, solved the problem of overreliance on clinical experience for traditional acupoint localization, but the accuracy and repetition rate of its localization still need to be improved. This paper proposes a hand acupoint localization method based on the dual-attention mechanism and cascade network model. First, by superimposing the dual-attention mechanism SE and CA in the YOLOv5 model and calculating the prior box size using K-means++ to optimize the hand location, we cascade the heatmap regression algorithm with HRNet as the backbone network to detect 21 predefined key points on the hand. Finally, “MF-cun” is combined to complete the acupoint localization. The FPS value is 35 and the average offset error value is 0.0269, which is much lower than the error threshold through dataset validation and real scene testing. The results show that this method can reduce the offset error value by more than 40% while ensuring real-time performance and can combat complex scenes such as unequal lighting, occlusion, and skin color interference.
Dual-band plasmon-induced transparency based on a vanadium dioxide ring resonator terahertz metamaterial
Authors: Wang Yunqing , Lang Peng , Ji Boyu , Xu Yang , Song Xiaowei , Lin Jingquan
Published: October 2023

A dynamically tunable dual-band plasmon-induced transparency metamaterial structure based on a vanadium dioxide ring resonator is proposed in this work. Two discrete transparent windows are excited in the terahertz spectrum and analyzed with a multipole expansion method for this system. A broader transparent window is formed by the destructive interference of the electric dipole and magnetic dipole modes, while the other is induced by the excitation of a pseudo-anapole mode, which originates from the coupling of the higher order multipoles of magnetic dipole and electric quadrupole. Based on this proposed system, the sensing sensitivity can reach 160 and 37 GHz/RIU with group delays of 3.4 and 37.9 ps at these two transparent windows. The proposed metamaterial device provides a new pathway for the design of the PIT effect for sensing, optical storage, and new terahertz functional devices.
Active matrix driven electrophoretic display with in-plane switching layout and driving waveform for reflective and transparent modes
Authors: Liu Yunhe , Fan Qitian , Liu Guangyou , Li Zhuohang , Liu Jie , Yang Jinglan , Zhou Tao , Zeng Zheng , Qin Zong , Yang Bo-Ru
Published: October 2023

In-plane switching electrophoretic display (IPS-EPD) is an emerging field of display technology which achieves particles moving horizontally through a lateral electric field. Compared to vertically driven electrophoretic display (V-EPD), IPS-EPD exhibits the feasibility of transparent display function. However, most of the previous research was hindered by long response time, low optical transmittance, or complex structures. In this paper, we have proposed a newly developed electrode layout and driving waveform for IPS-EPD, achieving a device with fast response time of 0.32 s, high transmittance of 58.07%, good transmittance-contrast ratio of 11.25, and simple structure, which show a significant improvement over other related research. Additionally, we elucidated the physical mechanism for the device through developing a particles motion simulation. Finally, we presented a prototype of an IPS-EPD with TFT panel, which exhibits excellent performance in various application scenarios, making it a possible application prospect in mobile phone cases, glasses, windows, and so on.
Electrostatic discharge induced degradation of optical-electrical properties and defect evolution of GaAs-based oxide-confined VCSELs
Authors: Zhang Jide , Yang Shaohua , Liao Wenyuan , Wang Puning , Liu Yuebo , Lu Guoguang , Wang Xiaohua , Wei Zhipeng
Published: October 2023

GaAs-based oxide-confined vertical-cavity surface-emitting lasers (VCSELs) exhibit relatively low resistance against reliability-related damage. In order to gain a deeper understanding of the degradation and failure mechanism in oxide-confined VCSELs caused by electrostatic discharge (ESD)-induced defect proliferation, we investigated the effects of ESD stress on the degradation of optical-electrical characteristics and the evolution of defects in VCSELs under human body model test condition. The degradation threshold values for forward and reverse ESD pulse amplitudes were estimated to be 200 V and -50 V, respectively. Notably, VCSELs demonstrated greater sensitivity to reverse bias ESD compared to forward bias ESD. Analysis of optical emission and microstructure provided evidence that the device failure is attributed to an increase in ESD current density, leading to the multiplication of dark line defects (DLDs) originating from the edge of the device's oxide aperture. The formation of defects occurred suddenly in discrete events within small regions, rather than progressing gradually and uniformly. These defects propagated and led to damage across the entire active region. We believe that our results would be meaningful for improving the reliability of VCSEL in the future.
Kinematic target surface sensing based on improved deep optical flow tracking
Authors: Lu Lei , Liu Hao , Fu Hongliang , Su Zhilong , Pan Wei , Zhang Qinghui , Wang Jinhui
Published: October 2023

Reconstruction of moving target surfaces based on active image sensing techniques, such as phase-shifting profilometry, has attracted intensive research in recent years. The measurement error caused by object motion can be addressed successfully by tracking the object movement. However, it either requires high-cost color imaging equipment or is limited by the assumption of 2D translation movement. Therefore, this paper proposes what we believe to be a new method to reconstruct the kinematic object surfaces with any 2D movement sensed by affordable monochrome camera. An improved RAFT optical flow algorithm is proposed to track the object based on the object fringe pattern image directly. The feature points on the object are retrieved immune to the fringe pattern illumination. Then, the RANSAC algorithm and an iteration selection process are employed to select feature points with high quality optical flow. At last, the motion is described mathematically, and the dynamic object is reconstructed successfully. Experiments are presented to verify the effectiveness of the proposed method.
Altruistic motivation or instrumental motivation: The spatial spillover effect of corporate social responsibility on corporate green innovation
Authors: Chen Doudou , Peng Zhen
Published: October 2023

In recent years, the concept of corporate social responsibility has gained more attention from investors, and green innovation has become a key factor in China’s economic growth. Despite this, regional disparities still remain, and the impact of corporate social responsibility on green innovation in local and surrounding areas is worth exploring. This article uses a Spatial Durbin Model to analyze the spatial spillover effect and mechanism of corporate social responsibility on green innovation of A-share listed companies in China from 2010 to 2020. The results show that corporate social responsibility behavior motivated by "tools" has a negative effect on local enterprises’ green innovation, while also having a negative spillover effect on surrounding areas, thus affecting the spatial pattern of green innovation. Further research suggests that fulfilling corporate social responsibility can attract investors, alleviate financing constraints, and change corporate resource investment strategies, thus promoting cross-regional resource flow and enhancing green innovation. The results of this study remain consistent when the matrix and variables are changed. This article provides new insights into corporate social responsibility and green innovation, and offers policy recommendations to improve green innovation in enterprises.