bluuebunny/crossref_metadata_2025 huggingface dataset:
ACCOUNTABILITY COMO ATRIBUTO AO CONTROLE SOCIAL DAS POLÍTICAS PÚBLICAS NO BRASIL
Authors: De Oliveira Reis Ana Karina Guimarães , Dumont Filipe Moreira , Da Silva Welesson Flávio , Martins Simone
Published: July 2023

O presente artigo objetiva analisar, de forma integrativa, os artigos científicos que relacionam o controle social à accountability publicados em periódicos disponibilizados na plataforma SCIELO. Como estratégia para a busca, foram filtrados os estudos acerca do tema, critérios de restrição e strings de busca em 4 etapas, os quais geraram uma amostra final de 18 artigos cujas temáticas atenderam à questão de pesquisa. Os resultados foram setorizados e apresentados em subseções para melhor compreensão das abordagens. As análises apontaram que há uma maior quantidade de estudos relacionados à temática no âmbito da saúde, os quais totalizam 52%; já se tratando das demais políticas públicas os resultados foram os seguintes: Assistência Social 8%, Educação 12%, Esporte 8%, Toda e qualquer política pública 16% e Trabalho 4%. O conteúdo dos artigos encontrados se mostrou satisfatoriamente diverso. Concluiu-se que, embora existam poucas publicações que fundamentam o controle social nos preceitos da accountability, os artigos encontrados revelam que o exercício do controle pode ser realizado de diferentes formas, o que vai de encontro aos estudos das instâncias formais de participação e controle social.
Systemic Lupus Erythematosus and Skin Damage: Patient’s Experience
Authors: Yosr Boussoukaya , Maissa Thabet , Syrine Kouki , Hana Elkarouss , Ahmed Guiga , Wissal Ben Yahia , Amel Amara , Amira Atig , Neirouz Ghannouchi
Published: July 2023

Systemic lupus erythematosus (SLE) is a non-organ-specific autoimmune disease that affects young patients and women in particular. We describe a Cross-sectional study conducted in the internal medicine department of Farhat Hached University Hospital in Sousse, Tunisia. We interviewed 12 patients with SLE about what they know about SLE, their skin symptoms and the measures they take on a daily basis to protect themselves. The DLQI questionnaire was used to evaluate their dermatological quality of life using.
Identity and Phenotypic Variability of a Passion Fruit Cultivar in Lucban, Quezon Province, Philippines
Authors: Presas Jeric , Trinidad Krizz Audrie , Borines Nic Oswald , Barrera Wilfredo
Published: July 2023

The passion fruit cultivar in Lucban, Quezon, Philippines is poorly described. To address this knowledge gap, this study characterized the phenotypic features and variability that exists in the plantation of passion fruit in Lucban. A total of 68 morpho-agronomic descriptors (32 quantitative and 36 qualitative) were used for the characterization. The results showed that the distinguishing characteristics of the cultivar were light green branch color, long and wide leaf with trilobate division and nectaries on the petiole, campanulate hypanthium, wavy corona filament, nectaries on the sepal, white color of the perianth and corona ring filaments with deep purple color at the base, and yellow peel and pulp color. Based on these characteristics, this study confirmed that the identity of the passion fruit cultivar is Passiflora edulis f. flavicarpa Degener. Some notable variants were observed – including purplish green branches, scarce anthocyanin on the reproductive parts, and fruit with oval fruit shape and lenticels arranged in a striated pattern. The scaled principal component analysis identified nine principal components (PCs) that explain at least 80% of the total variation in quantitative characters, whereas three PCs explain about 78% of the total variation in qualitative characters. Further characterization using molecular markers could be done to supplement the results of this study. Nevertheless, the results are significant for reintroduction, pre-breeding, and ex situ conservation of passion fruit germplasm.
Analisis Putusan Pengadilan Negeri Surabaya No. 746/Pdt.G/2021/Pn.Sby Tentang Pelanggaran Asas Itikad Baik Dalam Perjanjian Pengikatan Jual Beli Tanah di Kota Surabaya Dikaitkan Dengan Kitab Undang-Undang Hukum Perdata
Authors: Henokh Alexandro Pohan Rafael , Pujiwati Yani , Agus Saleh Kilkoda
Published: July 2023

Asas itikad baik dalam perjanjian merupakan faktor yang sangat penting. Dalam praktik peradilan di Indonesia standar dalam pengertian asas itikad baik dan kriteria itikad baik masih sangat beragam meskipun pengaturannya telah diatur pada Pasal 1338 ayat (3) Kitab Undang-Undang Hukum Perdata. Salah satunya adalah dalam kasus pada Putusan Pengadilan Negeri Surabaya Nomor 746/Pdt.G/2021/PN.Sby. Tujuan penelitian ini adalah untuk menganalisis pertimbangan majelis hakim dalam Putusan Nomor 746/Pdt.G/2021/PN.Sby berdasarkan Kitab Undang-Undang Hukum Perdata dan Peraturan Perundang-undangan lainnya yang berkaitan seperti Undang-Undang Nomor 5 Tahun 1960 dan Peraturan Pemerintah Nomor 24 Tahun 1997 dan untuk menentukan serta mengukur kriteria itikad baik dari seorang calon pembeli dalam melaksanakan transaksi jual beli tanah. Penelitian menghasilkan kesimpulan bahwa pertimbangan majelis hakim dalam Putusan Pengadilan Negeri Surabaya Nomor 746/Pdt.G/2021/PN.Sby tidak tepat dan bertentangan dengan fakta hukum karena majelis hakim tidak menggunakan Putusan Pengadilan Negeri Surabaya Nomor 891/Pid.B/2020/PN.Sby dan Putusan Nomor 892/Pid.B/2020/PN.Sby sebagai dasar pertimbangan, berdasarkan kedua putusan tersebut perjanjian pengikatan jual beli tanah antara para pihak seharusnya batal demi hukum dan pertimbangan majelis hakim dalam Putusan Nomor 746/Pdt.G/2021/PN.Sby dalam mempertimbangkan pembeli dinyatakan sebagai pembeli yang beritikad baik merupakan pertimbangan yang tidak tepat.
Pengaruh Kombinasi Genggam Jari dan Aromaterapi Jasmine Terhadap Nyeri Pasien Post Operasi Sectio Caesarea
Authors: Dewi Utaminingsih Triana , Agustina Rika , Misnawati Zuli , Sandiana Puput
Published: July 2023

Mothers with sectio caesarea will experience several problems such as pain, impaired mobility and anxiety. The pain felt by the mother of Sectio Caesarea can come from the incision scar under the abdomen. However, the severity of pain experienced by the mother will differ depending on the psychological and physiological as well as the pain tolerance experienced by the mother. Non-pharmacological therapies that can be given to reduce pain are a combination of finger grips and Jasmine aromatherapy. The method used in this study is a descriptive case study design with a case study approach based on the application of evidence-based practice of giving a combination of finger grip with jasmine aromatherapy. The sample of 2 people in this study was mothers after sectio caesarea surgery.  This case study was conducted in June 2022. The measuring instrument uses a numerical pain intensity scale. The results obtained from both pain subjects can decrease from moderate pain decreased to mild pain. There was a reduction in pain after a combination of finger grips and Jasmine aromatherapy in post-sectio caesarea mothers. Suggestions for the public are expected to be able to independently apply finger gripping techniques with a combination of jasmine aromatherapy in reducing pain.
Analysis of the Influence of Product Completeness, Service and Price on Consumer Repeat Purchase Decisions
Authors: Yusuf Susanto Andy , Sutanto J.E.
Published: July 2023

This study aims to determine the effect of product completeness, service, and price on consumer purchasing decisions at Sumber Sehat Departemen Store, Singaraja - Bali. The variables studied were product completeness (X1), service (X2), price (X3) and customer purchasing decision (Y). Product completeness variable has 4 (four) indicators, which are the diversity of products sold, the variety of products sold, the availability of products sold, and the availability of various brands. Service variable have 5 (five) indicators, which are physical facilities, reliability, certainty, responsiveness, empathy. Price variable has 3 (three) indicators, which are price affordability, price competitiveness and price benefits suitablility. Purchasing decision variable has 5 (five) indicators, which are product preference, brand preference, store preference, time preference and quantity preference. The analytical tool used is multiple linear regression with the help of SPSS software. The population in this study is the total consumers of Sumber Sehat Convenience Store in 2021, namely as many as 531 consumers and the sampling method used is Slovin formula with a tolerated margin of error of 5%, so that a sample of 228 respondents is obtained. The results of this study indicate that the variable product completeness, service and price have a positive and significant effect on the consumer purchasing decision variable. Furthermore, the variables of product completeness, services and prices simultaneously have a positive and significant effect on the consumer purchasing decision variable.
Efektifitas Pendidikan Kesehatan Tanda Bahaya Kehamilan Terhadap Kepatuhan Antenatal Care Di Masa Covid-19
Authors: Mardiana Ujung Riance
Published: July 2023

Every pregnancy carries risks for the mother. Early detection of danger signs and symptoms during pregnancy is the best effort to prevent serious disruption to pregnancy or the safety of pregnant women. During this Covid-19 pandemic, to get health services, you must maintain health protocols such as wearing masks, washing hands, and maintaining a minimum distance of 1 meter. The survey results found K1 in 2020 as many as 258 people (74.1%) and K4 as many as 198 people (57%). There are 24 pregnant women with high risk with causes including Chronic Energy Deficiency (KEK), grande multi gravida, pregnancy interval of less than 1 year, age at risk, hepatitis, HIV and Post SC. This study aims to see the effectiveness of providing health education about the danger signs of pregnancy on Antenatal Care Compliance during the Covid-19 Period. This type of research is an action research type of pre-experimental one-group pre-post test design, by means of a group before being given a pre-test and after a post-test. The population and sample were all pregnant women in the working area of ??the Siatas Barita Health Center who were present at the time of the implementation of the pregnant women class totaling 41 people. Test the validity of the instrument using the Corrected Item-Total Correlation of each question item. Reliability test using Croanbach's Alpha value. Methods Data analysis is the univariate method to get an overview of the frequency distribution of respondents from each variable. Bivariate analysis was carried out to test whether there was an effect of each independent variable with the dependent variable using Wilcoxon test statistics and the results were narrated. Based on the results of the questionnaire from 41 respondents, a pre-test was carried out as much as 29.3% had less knowledge and 70.7% had good knowledge. After the post test, there was an increase in knowledge of pregnant women even though there were still some who were lacking, namely 14.6% and 85.4% had good knowledge. In the table of results for the normality test, it shows that the value of sig. Pre test > 0.05, namely p = 0.062 and the value of sig. Post test > 0.05, namely p = 0.071, so it can be concluded that the results of the normality test of the pre-test and post-test of the research sample are normally distributed and can be continued with a different test using paired t-test with pre-test results of 21.00 ± 5.394 and posttest 23 ,05 ± 4,593. This means that there is an increase in respondents' knowledge about health education about pregnancy danger signs. Furthermore, based on the significance value (p-value) of 0.009 (<0.05). Based on the results of statistical tests, the treatment of health education about the danger signs of pregnancy has a significant influence on the knowledge of pregnant women about antenatal care compliance in pregnant women during the covid-19 period.
Fungsi Badan Permusyawaratan Desa dalam Pembentukan Peraturan Desa di Desa Sadha, Kecamatan Golewa Selatan, Kabupaten Ngada
Authors: Lidwina Meme Maria , Buyanaya Hyronimus , Tuan Yohanes
Published: July 2023

Badan Permusyawaratan Desa (BPD) sebagai badan legislative di tingkat Desa sekaligus wakil dari masyarakat Desa diberikan kewenangan penuh untuk menerapkan budaya demokrasi di tingkat Desa, baik dalam hal pengawasan terhadap pemerintah Desa maupun dalam hal penampungan aspirasi masyarakat Desa. BPD diharapkan menjadi wadah menampung aspirasi bagi masyarakat Desa untuk menyampaikan ide atau gagasan mereka agar dapat terealisasi dalam pembangunan dan kebijakan yang ada di Desa, berperan aktif dalam hal pelaksanaan tugas dan fungsinya. Tujuan dari penelitian ini adalah untuk mengetahuai peran BPD Desa Sadha, Kecamatan Golewa Selatan, Kabupaten Ngada dalam pembentukan peraturan Desa. Tipe penelitian yang digunakan dalam penelitian ini adalah penelitian deskriptif kualitatif. Analisa data pada penelitian yang bersifat kualitatif berlandasan pada penggunaan keterangan secara lengkap dan mendalam menginterprestasikan data tentang variable, bersifat non-kulitatif dan dimaksudkan untuk melakukan eksplorasi mendalam dan tidak meluas terhadap fenomena. Hasil penelitian menunjukkan bahwa kinerja BPD dalam bidang aspirasi masyarakat meliputi cara BPD dalam menampung aspirasi masyarakat. Cara yang dilakukan BPD dalam menampung dan menyalurkan aspirasi adalah dengan keterbukaan BPD dengan masyarat setempat.
Reflexión sobre la evolución histórica del principio de secreto profesional del abogado: el caso español
Authors: Monterde García Juan Carlos
Published: July 2023

El derecho-deber de secreto profesional es uno de los principios fundamentales de la Deontología jurídica. Este principioobliga principalmente al abogado a no revelar los datos confidenciales de sus clientes, especialmente en el ámbito penal. Reconocido internacionalmente en el mundo del Derecho, dicha figura en nuestro país es regulada en diversas normas, entre las que podemos destacar en primer lugar la Constitución Española de 1978 (en adelante, CE), donde se reconoce el derecho del abogado a no declarar contra su defendido. De igual modo, la Ley Orgánica del Poder Judicial (en adelante, LOPJ), el Código Penal (en adelante, CP) de 1995, y sobre todo el Estatuto General de la Abogacía Española (en adelante, EGAE) y el Código Deontológico de la Abogacía Española (en adelante, CDAE).Sin embargo, para entender los principios en los que se basa la normativa vigente, hemos de conocer los orígenes del deber general de secreto profesional, partiendo de la Antigüedad clásica (Grecia y Roma). El presente trabajo trata de profundizar en dichos antecedentes históricos, de manera particular en el caso español.
RANCANG BANGUN SISTEM INFORMASI PEMESANAN ANGGREK BERBASIS WEB PADA DESA DAUH PALA TABANAN
Authors: Agung Siaomitri Gusti Ayu , Agus Oka Gunawan I Made , Sandi Wiarsana I Gede
Published: July 2023

Masyarakat Desa Dauh Pala Kabupaten Tabanan merupakan salah satu masyakarat yang membudiyakan beberapa jenis anggrek. Namun proses pemasaran anggreknya masih dilakukan secara manual. Proses pemasaran secara manual tentu memiliki kelemahannya, dimana pada era bisnis digital ini konsumen tentunya akan lebih tertarik apabila dapat melihat katalog dalam sebuah website penjualan. Berdasarkan kajian yang dilakukan, sebuah sistem informasi pemesanan sangat berperan dalam memaksimalkan operasional sebuah pemesanan barang. Sehingga untuk mendukung layanan operasional pada hasil budidaya masyarakat Desa Dauh Pala perlu dikembangkan sistem informasi yang akan mempermudah kegiatan pemesanan anggrek. Berdasarkan penelitian yang telah dilakukan, sistem berhasil dirancang menggunakan model perancangan Data Flow Diagram dan Entity Relationship Diagram. Pengembangan sistem informasi pemesanan anggrek berbasis web berhasil dilakukan dengan menggunakan Framework Laravel. Hasil implementasi menghasilkan sistem yang dapat diakses oleh 2 jenis pengguna, dengan fungsionalitas utama adalah pengelolaan pesanan anggrek. Pengujian fungsionalitas dari setiap akses pengguna sistem telah dijalankan dengan baik menggunakan metode blackbox testing dengan hasil yang sesuai dengan kebutuhan fungsionalitas yang sudah ditetapkan pada akses administrator dan pemesan. Adapun saran yang dapat ditujukan untuk mengembangkan penelitian kedepannya adalah dapat dilakukan pengembangan lanjutan terkait fungsionalitas integrasi pembayaran dan jasa pengiriman.
HUBUNGAN ANTARA BEBAN KERJA DENGAN TURNOVER INTENTION PADA PERAWAT DI RUANG HCU RUMAH SAKIT Dr. ISKAK TULUNGAGUNG
Authors: Rahagia Rasi
Published: July 2023

Latar Belakang: Perawat merupakan salah satu tenaga kesehatan yang memiliki peran penting dalam memberikan pelayanan kesehatan kepada pasien. Beban kerja yang tinggi dapat merujuk pada tuntutan tugas yang berat, jumlah pasien yang banyak, jadwal kerja yang padat, dan tanggung jawab yang besar. Turnover intention merujuk pada niat atau keinginan individu untuk meninggalkan pekerjaan mereka dalam waktu yang relatif dekat. Tujuan: Untuk menganalisis hubungan beban kerja dengan turnover intension pada perawat di ruang HCU Metode: Penelitian ini yaitu analitik korelasional dengan pendekatan cross sectional. Sampel dalam penelitian ini berjumlah 37 orang. Sampel diambil dengan teknik purposive sampling. Hasil penelitian diuji dengan uji statistik Pearson dengan signifikansi α = <0,05 dengan program SPSS 23. Instrumen penelitian dengan menggunakan kuesioner beban kerja dan CBAS (Caring Behaviors Assessment Scale). Penelitian ini dilakukan di RS Dr. Iskak Tulungagung. Hasil: Hasil uji korelasi Pearson dengan taraf kesalahan (α) = 0,05, diperoleh nilai p = 0,011. Ini berarti ada hubungan signifikan antara beban kerja dengan turnover intension pada perawat di ruang HCU rumah sakit Dr. Iskak Tulungagung. Kesimpulan: Semakin rendah beban kerja semakin memungkinkan bagi perawat menunjukkan turnover intension dalam memberikan asuhan keperawatan.

 

Kata Kunci : Beban kerja, turnover intension, perawat
Organizational agility capabilities and sustainable competitive advantage in private multi-Practice hospitals in Kenya
Authors: Ngeche John , Kaluyu Veronicah
Published: July 2023

This study’s purpose was to explore the relationship between organizational agility and sustained competitive advantage among Kenyan Private Multi-Practice Hospitals (PMPHs). The study was driven by positivism philosophy and used a descriptive correlational research design. The target population included 690 managers from 46 private level 5 hospitals in Kenya from which a sample of 253 managers was obtained using stratified simple random sampling technique. To gather data, a standardized questionnaire was administered. The collected data were analysed using descriptive statistics (means, percentages, frequencies and standard deviations) and structural equation modelling. The findings from the study established that organizational agility of the PMPHs in Kenya had a significant positive effect on their sustained competitive advantage (β= 0.556, CR = 5.158, p <0.05). There are implications from the study findings for Kenya's private hospital administration to enhance the organizational agility capabilities of their hospitals such as sensing capabilities, leveraging capabilities and reconfiguration capabilities, as an avenue to effectively, and efficiently respond to the complex and dynamic external environment.
MENAKAR ARGUMENTASI YURIDIS-PASTORAL KEBIJAKAN USKUP DIOSESAN DALAM MEMBATASI LAYANAN SAKRAMEN PADA MASA PANDEMI COVID -19
Authors: Jehaut Rikardus
Published: July 2023

The purpose of the present article is to analyse the juridical and pastoral basis behind the policy on the limitation of sacramental service for the faithful introduced by Diocesan Bishop as the Church’s authority in the face of the spreading COVID -19 epidemic. The analysis aims to answer questions not only concerning the conformity of the policy with the Code of Canon law 1983, but also pertaining the issue of the rights of the faithful to receive sacrament. In relation to these questions, the author concludes that the introduction of the policy was adequate and necessary for the sake of the salvation of body of the people as a whole and in accord with the Church’s law. On the other hand, the author also point out that the above-mentioned policy must be always carried out properly without ignoring the rights of the faithful. Therefore, the article postulates that it is very important for the Diocesan Bishop to maintain a rational balance between the salvation of body of the people as a whole and Christ’s faithful’s rights to receive sacraments from the Church.
Architecture and enhanced-algorithms to manage servers-processes into network: a management system
Authors: AlFayez Fayez
Published: July 2023

This work investigates minimizing the makespan of multiple servers in the case of identical parallel processors. In the case of executing multiple tasks through several servers and each server has a fixed number of processors. The processors are generally composed of two processors (core duo) or four processors (quad). The meaningful format of the number of processors is 2k, and k ≥ 0. The problem is to find a schedule that minimizes the makespan on 2k processors. This problem is identified as NP-hard one. A new network architecture is proposed based on the addition of server management. In addition, two novel algorithms are proposed to solve the addressed scheduling problems. The proposed algorithms are based on the decomposition of the main problem in several sub-problems that are applied to develop new heuristics. In each level of the generated tree, some results are saved and used to decompose the set of processes into subsets for the next level. The proposed methods are experimentally examined showing that the running time of the proposed heuristics is remarkably better than its best rival from the literature. The application of this method is devoted to the network case when there are several servers to be exploited. The experimental results show that in 87.9% of total instances, the most loaded and least loaded subset-sum heuristic (MLS) reaches the best solution. The best-proposed heuristic reaches in 87.4% of cases the optimal solution in an average time of 0.002 s compared with the best of the literature which reaches a solution in an average time of 1.307 s.
Farm Diversification in Haryana, India: Case Studies
Authors: Jose Elizabeth , Ponnusamy K.
Published: July 2023

In the late 1960s, the Green Revolution enabled India to overcome a severe food shortage and achieve food grain self-sufficiency, particularly in the case of wheat and paddy. Continuous mono cropping system threatens the sustainability of future agricultural production in terms of soil, water, climate and market parameters which warrants a diversified farming system enabling farmers to use their resources efficiently with its ecological benefits. Recent trends in crop farming witnessed a multifold shift towards paddy and wheat specialization in Haryana. So farm diversification is an important strategy to maintain the sustainability of state agriculture. The present study was undertaken to explore the potential of farm diversification in Haryana. Case studies were conducted among selected farmers from the three districts representing three agro ecological zones of Haryana (Kaithal from AEZ1, Hisar from AEZ2 and Bhiwani from AEZ3). The case study included parameters like area and number of enterprises and cost details and net returns from each diversified enterprise. The study concludes that, various methods utilized by the successful farmers specialized in a particular venture serve as the model for fellow farmers who are similarly interested in the same experience. Subsidies, incentives and training programmes of government agencies promoted the farmers to get involved in the allied enterprises. This study highlights the need for incentives and training programmes for further promoting farm diversification in the state.
Use of Some Metalferrites as Catalyst in Benzil-Benzilicacid Rearrangement Reaction
Authors: Godha Neha , Ameta Suresh C.
Published: July 2023

Magnesium ferrite was used to catalyse the Benzil-Benzilic acid rearrangement reaction of 1,2-rearrangement of 1,2-diketones to α-hydroxy carboxylic acids in presence of a base. Magnesium ferrite was prepared by hydrothermal process. It was characterized by Field Emission Scanning Electron Microscopy (FESEM), X-Ray Diffraction Spectroscopy (XRD), and Energy Dispersive X-Ray Spectroscopy (EDX). The crystalline size of magnesium ferrite was found to have 82.47nm and these are irregular in shape. It was found that the yield of the product (benzilic acid) in the presence of Mg ferrite was 81.6%, which is almost 2.3 times the yield obtained in the absence of catalyst. A comparative study was made with different metal ferrites as catalyst and it was found that the activity of metal ferrites followed the order:
MgFe2O4 > Cu Fe2O4 > Ni Fe2O4 > Co Fe2O4 > Zn Fe2O4
Effectiveness of Extension and Advisory Services Provided by Input Dealers during COVID-19 Pandemic
Authors: Mathuabirami V. , Karthikeyan C. , Devi M. Nirmala , Ganapati Patil Santosh , J. Paul Mansingh
Published: July 2023

Aim: The main aim of this research is to study the input dealers’ perception towards the extension ad advisory services provided during COVID-19 pandemic.

Study Design: Cross section research design.

Place and Duration of Study: Coimbatore and Tiruvallur districts of Tamil Nadu, India. Two years (2021-2022).

Methodology: From the selected two districts 70 extension officials were randomly selected for conducting the study. Data were collected from the input dealers who delivered extension and advisory services to farmers during COVID-19 pandemic. Paper-Pencil survey method was used to collect data from the farmers. The survey approach is useful for evaluating opinions and trends by gathering quantitative data. A separate scale was developed for assessing the input dealer’s perception towards the effectiveness of extension and advisory services. CIPP model of evaluation was used for developing scale to measure the input dealer’s perception towards the EAS. The developed scale were validated by the experts. A scale was measured using 5-point Likert scale with 1 denoting "strongly disagree and 5 denoting “strongly agree” were employed in this study.

Results: Majority of the input dealers (70.00%) had medium to very high level of perception towards the effectiveness of extension and advisory services. Input dealer’s perceived that they possessed necessary skills and experience for delivering extension and advisory services. They also perceived that services were made available to farmers on time, door delivery of services were provided, increased agricultural production and productivity of farmers which lead to increased income of the farmers.

Conclusion: Effectiveness of extension and advisory services provided by input dealers during COVID-19 pandemic was effective in input dealer’s perception. Therefore policy makers must propose a policy in a way that government service provider will work along with the input dealers for delivering extension and advisory services to the farming community. Pluralistic extension approach will be the best option for extension service provider.
Evaluation of Genetic Diversity in Sodic Soil-grown Barnyard Millet (Echinochloa frumentacea (Roxb.) Link) Germplasm
Authors: Sampath L. , Dhanalakshmi R. , Kalaimagal T. , Susmitha D. , Antony B. J.
Published: July 2023

Aims: Barnyard millet (Echinochloa frumentacea) is a significant tiny millet crop characterized by because of its high nutritional value, exceptional ability to withstand extremes of climate, and short duration. Globally, the area under salt affected soil is expanding. Therefore, genetic diversity analysis was conducted to identify genetically diverse genotypes for yield improvement under sodic condition.

Study Design: Randomised block design.

Place and Duration of Study: An experiment was carried under sodic soil condition at Anbil Dharmalingam Agricultural College and Research Institute, Trichy, Tamil Nadu.

Methodology:  Ninety two genotypes of barnyard millet, including two commercial check varieties, MDU1 and CO (KV) 2. Plant height (cm), inflorescence length (cm), inflorescence width (cm), lower raceme length (cm), flag leaf length (cm), flag leaf width (cm), number of leaves on main tiller, number of productive tillers per plant, and grain yield per plant (g) were the nine quantitative traits that were recorded. GENRES software version 3.11 was used for analysing the data.

Results: For all of the analysed attributes, the genotypes showed significant differences based on the analysis of variance. Ninety two genotypes were divided into nine groups according to nine quantitative features using Mahalanobis D2-Statistics. Cluster II was the one with the greatest number with 25 genotypes, followed by cluster V with 22 genotypes, Cluster VI with 17 genotypes, Cluster IV with 11 genotypes, Cluster I with 8 genotypes, Cluster VIII with 4 genotypes, Cluster III and VII with only 2 genotypes per cluster, and Cluster IX with just 1 genotype. Cluster IV was second in terms of intra-cluster distance, after Cluster VIII. The largest inter-cluster distance was observed between clusters I (TNAUF01000021 - EF 37, TNAUF01000022 - EF 38, TNAUF01000022 - EF 39, etc.) and IX (MDU1).

Conclusion: Choosing these genotypes as parents from genetically diverse clusters for breeding programmes might produce heterotic hybrids that produce enough genetic diversity in barnyard millet genotypes under sodic soil conditions.
Lived Experiences of Patients Hospitalized With Acute Decompensated Heart Failure and Kidney Dysfunction
Authors: Bernacki Gwen M. , O’Hare Ann M. , Assefa Mahlet , O’Brien Kevin D. , Prince David K. , Kirkpatrick James N. , Bansal Nisha , Butler Catherine R.
Published: January 2025

Importance

For patients hospitalized with acute decompensated heart failure (ADHF), the presence of kidney dysfunction can substantially shape prognosis and treatment options. Yet little is known about the lived experiences of these medically vulnerable patients.

Objective

To elicit accounts of the illness and care experiences of patients currently or recently hospitalized with ADHF and kidney dysfunction in order to identify potential opportunities to improve care.

Design, Setting, and Participants

This qualitative study of patients with ADHF and kidney dysfunction was conducted at 3 hospitals within an academic health system serving the Greater Seattle area between February 2022 and February 2023. Patients were recruited from those enrolled in a parent study of patients hospitalized with ADHF. A sample of patients who had either acute kidney injury and/or chronic kidney disease were invited to participate in 1 or more qualitative interviews during hospitalization or approximately 3 months postdischarge.

Main Outcomes and Measures

Transcribed interviews were analyzed using inductive thematic analysis.

Results

A total of 40 interviews were conducted among 28 participants. The mean (SD) participant age was 67 (12) years, and 8 (28%) identified as female, 4 as Black [14%], and 20 as White [71.4%]. Qualitative analysis resulted in 4 dominant themes: (1) pervasive impact of functional limitation, (2) adapting goals and changing expectations, (3) struggling to interpret clinical information, and (4) decisional roles and relationships with clinicians. Participants described how their illness had shaped their day-to-day function, life space, and sense of self. They did not always speak in explicit terms about prognosis but most recognized limits on longevity and life options and had started to rethink their priorities. Most participants were engaged in a process of trying to understand the medical aspects of their illness and care, often drawing on their own embodied experience of illness. They had particular difficulty grasping the significance of kidney dysfunction and connecting this to the symptoms they were experiencing. Participants did not always feel equipped or empowered to engage in clinical decision-making, tending to trust the clinicians caring for them.

Conclusions and Relevance

Interviews with adults currently or recently hospitalized with ADHF and kidney dysfunction highlight the importance of improving education, communication, and engagement in care among members of this medically vulnerable group.
A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria
Authors: Dunkley Truman , Shain Daniel H. , Klein Eric A.
Published: January 2025

Bioenergetic profiles of psychrophiles across domains of life are unusual in that intracellular ATP levels increase with declining temperature. Whole‐transcriptome sequencing of the glacier ice worm Mesenchytraeus solifugus revealed a unique C‐terminal extension on the ATP6 protein, which forms part of the proton pore of mitochondrial ATP synthase (Complex V). This extension, positioned near the proton exit pore, comprises alternating histidine residues thought to increase proton flux through Complex V leading to elevated ATP synthesis. To test this hypothesis, we fused the M. solifugus C‐terminal extension to Escherichia coli AtpB (the ATP6 orthologue) and observed a ~ 5‐fold increase in ATP synthesis. This enhancement was unidirectional as we observed no change to ATP hydrolysis rates. These findings offer an avenue for identifying critical factors associated with ice worm adaptation.
FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production
Authors: Otsuka Yushi , Yano Masato
Published: January 2025

FAM136A deficiency has been associated with Ménière's disease. However, the underlying mechanism of action of this protein remains unclear. We hypothesized that FAM136A functions in maintaining mitochondria, even in HepG2 cells. To better characterize FAM136A function, we analyzed the cellular response caused by its depletion. FAM136A depletion induced reactive oxygen species (ROS) and reduced both mitochondrial membrane potential and ATP production. However, cleaved caspase‐9 levels did not increase significantly. We next investigated why the depletion of FAM136A reduced the mitochondrial membrane potential and ATP production but did not lead to apoptosis. Depletion of FAM136A induced the mitochondrial unfolded protein response (UPRmt) and the expression levels of gluconeogenic phosphoenolpyruvate carboxykinases (PCK1 and PCK2) and ketogenic 3‐hydroxy‐3‐methylglutaryl‐CoA synthases (HMGCS1 and HMGCS2) were upregulated. Furthermore, depletion of FAM136A reduced accumulation of holocytochrome c synthase (HCCS), a FAM136A interacting enzyme that combines heme to apocytochrome c to produce holocytochrome c. Notably, the amount of heme in cytochrome c did not change significantly with FAM136A depletion, although the amount of total cytochrome c protein increased significantly. This observation suggests that greater amounts of cytochrome c remain unbound to heme in FAM136A‐depleted cells.
Biomimetic Fibrous Bone Substitute Manufacture Through Non‐Solvent‐Assisted 3D Printing
Authors: Zhang Kunxi , Fang Haowei , Cheng Xiangyang , Li Jinyan , Zeng Jiujiang , Zhang Tao , Cui Haiyan , Gu Huijie , Yin Jingbo
Published: January 2025

The manufacturing of biomimetic bone characterized by an organic–inorganic combination and fibrous structure has garnered significant attention. Inspired by the formation of multi‐layered fibrous structures in bone tissue, this study is based on the fibril assembled from poly(γ‐benzyl‐L‐glutamate) (PBLG) in helicogenic solvent, proposing a non‐solvent‐assisted 3D printing method for realizing the PBLG 3D printing while generating biomimetic fiber structures in One‐Step to mimic the formation of collagen fiber bundles. The unprintable mixture of PBLG and hydroxyapatite nanoparticles (nHA) in 1,4‐dioxane exhibits extrudability, self‐supporting properties, and plasticity in ethanol. Meanwhile, ethanol‐assisted printing leads to the spontaneous growth of PBLG‐fibrils into submicron‐fibers. Moreover, the integration of nHA with PBLG‐fibers through hydrogen bonding contributes to the improvement of printability and mechanical properties. This method of ethanol‐assisted fiber generation is successful with concentrated PBLG solutions, overcoming the limitation of previous research that focused only on dilute solutions. To expand the printable window, an ethanol‐gel is developed as a support to achieve omnidirectional printing, resolving the issue of interlayer collapse caused by gravity and the conflict between printability and biomimetic fibers generation, optimizing the biomimetic bone manufacturing, leading to the precise biomimetic design of bone structures.
Gravity‐Switch‐Triggered Triboelectric Nanogenerator for Multi‐Directional Wave Energy Harvesting
Authors: Huo Da , Yang Xinglin , Pan Yijiang , Su Jianye
Published: January 2025

As global energy demands increase, reliance on fossil fuels intensifies environmental and resource pressures, driving the exploration of renewable sources. With its high energy density and potential to meet global energy needs, wave energy attracts significant attention. Despite the abundance of wave energy resources, efficiently harvesting multi‐directional wave energy remains challenging. This study introduces a gravity‐switch‐triggered triboelectric nanogenerator (GS‐TENG) designed to enhance the efficiency of wave energy collection. The GS‐TENG uses a gravity switch to control circuit connections and disconnections, optimizing the internal structure and experimentally adjusting the number of nylon balls to enhance output performance. In experiments, the GS‐TENG demonstrated adaptability to various wave directions and achieved a short‐circuit current of 22.2 µA, an open‐circuit voltage of 196 V, and a transferred charge of 75 nC under specific conditions. This showcases its superior performance in low‐frequency wave energy collection. Additionally, the device successfully lit 100 LEDs in a simulated wave environment, validating its potential for practical applications. The research on GS‐TENG provides an effective approach for harvesting wave energy and lays significant theoretical and experimental foundations for further development of wave energy collection technologies.
Covalent Affibody‐Molecular Glue Drug Conjugate Nanoagent for Proximity‐Enabled Reactive Therapeutics
Authors: Gao Wenhui , Yang Xiaoyuan , Li Qingrong , Liu Yingchun , Huang Wei , Xia Xuelin , Yan Deyue
Published: January 2025

Sulfur‐fluoride exchange (SuFEx) reaction is an emerging class of click chemistry reaction. Owing to its efficient reactivity under physiological conditions, SuFEx reaction is used to construct covalent protein drugs. Herein, a covalent affibody‐molecular glue drug conjugate nanoagent is reported, which can irreversibly bind with its target protein through proximity‐enabled SuFEx reaction. As a proof of concept, a latent bioreactive unnatural amino acid fluorosulfate‐L‐tyrosine (FSY) is first introduced at site 36 of the affibody with cysteine mutation (ZHER2:342‐Cys) to produce ZHER2:342‐36FSY‐Cys. Subsequently, ZHER2:342‐36FSY‐Cys is coupled with a molecular glue drug (CR8) to yield an amphiphilic conjugate of ZHER2:342‐36FSY‐CR8, which can self‐assemble into affibody–drug conjugate nanoagent (ZHER2:342‐36FSY‐CR8 ADCN) in PBS. When ZHER2:342‐36FSY‐CR8 ADCN specific binds to human epidermal growth factor receptor 2 (HER2) on cancer cells, the FSY36 of ZHER2:342 approaches to the His490 of HER2 and ultimately reacts with each other to form a covalent bond via SuFEx reaction. Such a covalent binding mode endows ZHER2:342‐36FSY‐CR8 ADCN with permanent binding ability to effectively increase the concentration of drugs in tumor. Eventually, the covalent ZHER2:342‐36FSY‐CR8 ADCN exhibits an outstanding tumor inhibition ratio of 90.03 ± 4.29% in HER2‐positive ovary tumor models, strikingly higher than that of the noncovalent one (64.25 ± 7.71%).
Machine Vision Applications for Welfare Monitoring in Aquaculture: Challenges and Opportunities
Authors: Fitzgerald Amy , Ioannou Christos C. , Consuegra Sofia , Dowsey Andrew , Garcia de Leaniz Carlos
Published: January 2025

Increasing consideration of welfare in aquaculture has prompted interest in non‐invasive methods of monitoring that avoid unnecessary stress and handling. Machine vision (MV) provides a potential solution to these needs, as it can be used for non‐invasive monitoring of animal health and welfare in real‐time. We examined the practical applications of MV for welfare monitoring in aquaculture, the hardware and algorithms used for automated data collection, and the main challenges and solutions for data processing and analysis. The most common application of MV has been the estimation of size‐related metrics (growth, biomass) in fish, but key aspects of welfare, such as monitoring of parasites and disease or detection of stress‐related behaviours, are lagging behind. Numerous camera setups have been used, ranging from single to stereoscopic cameras and from emersed to submerged cameras, but these have often been used under optimal conditions that may not always reflect those prevalent in industry (high densities, low visibility), likely overestimating performance. Object detection algorithms, such as YOLO, have been the approach of choice for most MV applications in aquaculture, but our review has identified an increasing number of alternatives that can help circumvent some of the challenges posed by high densities and poor lighting typical of commercial farms. MV has the potential to transform welfare monitoring in aquaculture, but there are still important challenges that need to be overcome before it can become mainstream, namely the ability to detect ectoparasites and diseases, identify abnormal behaviours, and work across taxa, particularly in crustaceans.
3D Rotary Wet‐Spinning (RoWS) Biofabrication Directly Affects Proteomic Signature and Myogenic Maturation in Muscle Pericyte–Derived Human Myo‐Substitute
Authors: Reggio Alessio , Fuoco Claudia , De Paolis Francesca , Deodati Rebecca , Testa Stefano , Celikkin Nehar , Volpi Marina , Bernardini Sergio , Fornetti Ersilia , Baldi Jacopo , Biagini Roberto , Seliktar Dror , Cirillo Carmine , Swieszkowski Wojciech , Grumati Paolo , Cannata Stefano , Costantini Marco , Gargioli Cesare
Published: January 2025

Skeletal muscle tissue engineering (SMTE) has recently emerged to address major clinical challenges such as volumetric muscle loss (VML). Here, we report a rotary wet‐spinning (RoWS) biofabrication technique for producing human myo‐substitutes with biomimetic architectures and functions. Here, we demonstrate how the proposed technique may be used to establish a well‐tailored, anisotropic microenvironment that promotes myogenic differentiation of human skeletal muscle–derived pericytes (hPeri). Using high‐resolution mass spectrometry–based proteomics with the integration of literature‐derived signaling networks, we uncovered that (i) a 3D biomimetic matrix environment (PEG‐fibrinogen) confers a less mitogenic microenvironment compared to standard 2D cultures, favoring the formation of contractile‐competent bundles of pericyte‐derived myotubes in an anchoring‐independent 3D state and (ii) the RoWS method promotes an upregulation of muscle matrix structural protein besides increasing contractile machinery proteins with respect to 3D bulk cultures. Finally, in vivo investigations demonstrate that the 3D‐biofabricated myo‐substitute is fully compatible with the host ablated muscular tissue, exhibiting myo‐substitute engraftment and muscle regeneration in a mouse model of VML. Overall, the results show that RoWS offers a superior capability for controlling the myogenic differentiation process on a macroscale and, with future refining, may have the potential to be translated into clinical practice.
Sprayed Aqueous Microdroplets for Spontaneous Synthesis of Functional Microgels
Authors: Li Xin , Zhang Wenjing , Li Helin , Shuai Qi , Zhang Xingcai , Pich Andrij
Published: January 2025

The development of sustainable synthesis route to produce functional and bioactive polymer colloids has attracted much attention. Most strategies are based on the polymerization of monomers or crosslinking of prepolymers by enzyme‐ or cell‐mediated reactions or specific catalysts in confined emulsions. Herein, a facile solution spray method was developed for spontaneous synthesis of microgels without use of confined emulsion, additional initiators/catalysts and deoxygenation, which addresses the challenges in traditional microgel synthesis. The polarization of air‐water interface of the microdroplets can spontaneously split hydroxide ions in water to produce hydroxyl radicals, thereby initiating polymerization and crosslinking in air environment. This synthesis strategy is applicable to a variety of monomers and enables the fabrication of microgels with tunable chemical structures and variable sizes. Importantly, the synthesis route also allows for the preparation of enzyme‐ or drug‐loaded microgels via the in situ encapsulation, which also display high enzymatic activity and stimuli‐triggered drug release. Therefore, this work not only is of great significance to macromolecular science and microdroplet chemistry, but also may bring new insights into cellular biochemistry and even prebiotic chemistry due to the prevalence of microdroplets in the environment.
Ultrasonic‐Assisted Adsorptive Uptake of Malachite Green Dye Onto Zn/Cu‐Layered Double Oxide: Spectrophotometric and Smartphone‐Based Detection
Authors: Pandey Bhamini , Singh Poonam , Kumar Ravinder
Published: January 2025

In this work, efforts have been made to synthesize novel Zn/Cu‐layered double oxide by performing calcination of Zn/Cu‐layered double hydroxide, which was later used as an adsorbent for the uptake of toxic azo dye. Malachite green (MG) was used as a model cationic dye for assessing the practicability of dye wastewater treatment. From batch experiments study, it was evident that ultrasonication‐assisted adsorption enables 90% of the MG to be removed from water within 30 min at neutral pH conditions. The ultrasound‐assisted sorption process was driven by the acoustic cavitation process, which facilitated a homogeneous distribution of active adsorption sites on surface of the adsorbent resulting efficient removal of dye molecules. As predicted by the Langmuir isotherm model, the sorbent exhibited maximum adsorption capacity of 128.20 mg/g, and based on kinetic measurements, the pseudo‐second‐order adsorption model was found to be most accurate. The kinetic studies also revealed that intraparticle diffusion is the rate‐limiting step of the adsorption process. The current study also demonstrates smartphone‐assisted estimation of adsorbed MG dye in order to provide a simple, convenient, cost‐effective, and instrument‐free method to quantify dye concentration. A smartphone‐based app called “ColorPicker” was used to calculate MG dye adsorption rate in real time based on RGB values and colorimetric responses. The percent removal obtained using smartphone app (87%) was in agreement with the data obtained using UV–vis spectroscopy (90%). As a result of its excellent properties, Zn/Cu‐LDO appears to be a potential candidate for wastewater remediation.