bluuebunny/crossref_metadata_2025 huggingface dataset:
Ekspresi Protein Resuscitation promoting factor-D Mycobacterium tuberculosis pada sel CHO-K1 secara in-vitro
Authors: Pratama Wahyu Agung , Rukmana Andriansjah , Sjatha Fithriyah
Published: October 2020

Abstrak Protein Resuscitation promoting factor–D (Rpf-D) merupakan protein transmembran dari Mycobacterium tuberculosis dan dieskpresikan pada fase reaktivasi infeksi laten menjadi aktif. Protein Rpf-D tersusun atas 154 asam amino berukuran 16 kDa yang dikode oleh 456 basa dari famili gen-Rpf. Pada studi sebelumnya, kami telah berhasil mengklona gen rpfD dari Mycobacterium tuberculosis strain Beijing kedalam plasmid pcDNA3.1, dikenal sebagai pcDNA3.1-rpfD. Dalam studi ini, kami mentransfeksi sel mamalia CHO-K1 dengan plasmid rekombinan pcDNA3.1-rpfD dan dilanjutkan dengan pewarnaan imunologis menggunakan serum mencit yang telah diimunisasi dengan pcDNA3.1-rpfD sebagai vaksin DNA. Hasil pewarnaan menunjukkan bahwa protein RpfD mampu diekspresikan pada sel mamalia. Selain itu, protein rekombinan yang diekspresikan ini terbukti bersifat imunogenik dan mampu menginduksi respon imun humoral pada hewan uji mencit Balb/C berupa IgG1, IgG2a, IgG2b dan IgG3. Hasil penelitian ini menunjukan potensi pemanfaatan protein rekombinan RpfD untuk penelitian lanjutan pengembangan vaksin ataupun uji diagnosis tuberkulosis. Kata kunci: Resuscitation promoting factor-D, Mycobacterium tuberculosis, sel CHO-K1, transfeksi, immunostaining Abstract Resuscitation promoting factor-D (Rpf-D) protein is known as a component of Mycobacterium tuberculosis cell wall which highly expressed in reactivation state of latent tuberculosis to turn in to an active infection. Rpf-D protein is a small protein consist of 154 amino acids encoded by 465 nucleotides in Rpf-gene family and having 16 kDa in size. In our previous study, we had successfully cloned Rpf-D gene of Mycobacterium tuberculosis Beijing strain into pcDNA3.1 plasmid expression system, which named as pcDNA3.1-rpfD later on. In this study, we transfect pcDNA3.1-rpfD into CHO-K1 mammalian cell line followed by immunostaining using mice sera immunized with pcDNA3.1-rpfD as DNA vaccine. Our result shows that our recombinant pcDNA3.1-rpfD construct can express recombinant RpfD protein in mammalian cells. On the other hand, this expressed recombinant protein has been proven to be immunogenic and able to induce a humoral immune response in Balb/C mice especially IgG1, IgG2a, IgG2b, and IgG3. Our study has shown the potency of recombinant RpfD protein which can be further developed as vaccine or diagnostic approach for tuberculosis. Keywords: Resuscitation promoting factor-D, Mycobacterium tuberculosis, CHO-K1 cells, transfection, immunostaining
Efek Protektif Sinergis Kombinasi Minyak Jintan Hitam (Nigella sativa) Komersial dan Madu terhadap Nefrotoksisitas pada Tikus akibat Cisplatin
Authors: Noviana Rita , Ilmiawan Muhammad In‟am , Handini Mitra
Published: October 2020

Abstrak Cisplatin (CP) merupakan agen kemoterapi yang banyak digunakan dan menyebabkan nefrotoksisitas. Minyak jintan hitam (MJH) dan madu (M) diketahui memiliki efek nefroprotektif. Tujuan: Mengetahui efek dan sinergitas kombinasi MJH dan madu pada kadar malondialdehid (MDA) ginjal tikus yang diberi pajanan CP. Metode: Penelitian ini menggunakan 30 ekor tikus jantan yang dibagi menjadi 10 kelompok: Kontrol Normal (KN) (diet ad libitum), MJH1 (1 mL/kgBB MJH), MJH2 (2 mL/kgBB MJH), M1 (3,7 mL/kgBB M), M2 (7,4 mL/kgBB M), MJH1-M1 (1 mL/kgBB MJH dan 3,7 mL/kgBB M), MJH1-M2 (1 mL/kgBB MJH dan 7,4 mL/kgBB M), MJH2-M1 (2 mL/kgBB MJH dan 3,7 mL/kgBB M), MJH2-M2 (2 mL/kgBB MJH dan 7,4 mL/kgBB M), dan CP (diet ad libitum). MJH dan madu diberikan secara oral selama 21 hari. Pada hari ke-18, KN diberikan NaCl 0,9% 1 ml/kgBB sedangkan sisanya diberikan CP dosis tunggal 8 mg/kgBB secara intraperitoneal. Kadar MDA ginjal diukur menggunakan metode thiobarbituric acid reactive substances (TBARS). Didapatkan kadar MDA ginjal yang lebih rendah pada semua kelompok dosis tunggal dan kombinasi dibandingkan dengan kelompok CP (p=0,000). Semua kelompok dosis kombinasi memiliki indeks kombinasi <1. Kombinasi MJH dan madu memberikan efek protektif sinergis terhadap kerusakan oksidatif jaringan ginjal tikus akibat pajanan CP. Kata kunci: Minyak jintan hitam, madu, indeks kombinasi, cisplatin, nefrotoksisitas Abstract Cisplatin (CP) is a widely used chemotherapeutic agent that induces nephrotoxicity. Nigella sativa oil (NSO) and honey (H) have demonsrated nephroprotective effect. To investigate the effect and synergy of NSO and honey combination on kidney malondialdehyde (MDA) levels in CP-induced rats. Thirty male rats were divided into ten groups: Normal Control (NC), NSO1, NSO2, H1, H2, NSO1-H1, NSO1-H2, NSO2-H1, NSO2-H2, and CP-treated group which received ad libitum diet, 1 mL/kgbwt. NSO, 2 mL/ kgbwt. NSO, 3.7 mL/kgbwt. H, 7.4 mL/kgbwt. H, 1 mL/kgbwt. NSO and 3.7 mL/kgbwt. H, 1 mL/kgbwt. NSO and 7.4 mL/kgbwt. H, 2 mL/kgbwt. NSO and 3.7 mL/kgbwt. H, 2 mL/kgbwt. NSO and 7.4 mL/kgbwt. H, ad libitum diet, respectively, for 21 days. On the 18th day, NC group received 1 ml/kgbwt. NaCl 0.9% while the rest received 8 mg/kgbwt. single dose CP intraperitoneally. Kidney MDA levels was measured using thiobarbituric acid reactive substance (TBARS) method. Kidney MDA levels was significantly lower in all single and combination dose treatment groups compared to CP-treated group (p=0,000). Combination index of all combination dose treatment groups is <1. NSO and honey combination provided synergistic protective effect against CP-induced oxidative damage in kidney tissue in rats. Keywords: Nigella sativa oil, honey, combination index, cisplatin, nephrotoxicity
KESIAPAN MANAJEMEN PUSKESMAS DALAM MENJALANKAN PROGRAM INDONESIA SEHAT DENGAN PENDEKATAN KELUARGA (PIS-PK) DI INDONESIA
Authors: Mujiati Mujiati , Sugiharti Sugiharti , Masitoh Siti , Laelasari Eva
Published: October 2020

ABSTRACT

Indonesian Health Program with Family Approach (PIS-PK) is one of the health development priority programs by visiting family to increase target coverage and access to health services. This research was conducted by quantitative approach through interview using a structured questionnaire to Head of PHC or Head of Administration Division or PIS-PK officer) or PHC officer who understand about PIS-PK in 9699 PHC in 34 provinces. Data were analyzed descriptively. The results showed that PHC that had been trained in PIS-PK was better prepared in management compared to PHC that had not been trained. PHC that had been trained by PIS-PK were better prepared in availability of human resources, budget, RUK and RPK, availability of PIS-PK instruments, presence of socialization, availability of computers with internet access, monthly and quarterly administration has been carried out, and presence evaluation. PHC are expected to prepare these aspects so that they can be prepared management to carry out PIS-PK. It is expected that District/ city health offices able to carry out routine monitoring and evaluation, supervision and technical assistance to the PHC.

Keywords: Readiness; Primary health care’s management; Indonesian Health Program with Family Approach

 

ABSTRAK

Program Indonesia Sehat dengan Pendekatan Keluarga (PIS-PK) merupakan salah satu program prioritas pembangunan kesehatan yang dilaksanakan oleh Puskesmas dengan cara mendatangi keluarga untuk meningkatkan jangkauan sasaran dan akses pelayanan kesehatan. Program PIS-PK dilaksanakan secara bertahap sejak tahun 2016, oleh karena itu perlu dilakukan analisis tentang kesiapan manajemen Puskesmas dalam menjalankan PIS-PK.  Analisis dilakukan dengan menggunakan data laporan Riset Ketenagaan Kesehatan (Risnakes) 2017 terpublikasi. Data Risnakes dikumpulkan dengan pendekatan kuantitatif melalui wawancara menggunakan kuesioner terstruktur pada Kepala Puskesmas, Kepala Bagian Tata Usaha atau Penanggungjawab PIS-PK atau petugas puskesmas yang memahami tentang PIS-PK di 9.697 Puskesmas di 34 provinsi. Hasil analisis menunjukkan Puskesmas yang sudah melaksanakan pelatihan PIS-PK (78,8%) lebih siap secara manajemen dibanding dengan Puskesmas yang belum melaksanakan pelatihan PIS-PK (49,9%). Kesiapan dalam pelaksanaan PIS-PK  karena puskesmas lebih siap dalam aspek ketersediaan SDM, anggaran, telah disusunnya RUK dan RPK, ketersediaan instrumen PIS-PK, adanya sosialisasi, ketersediaan komputer dengan akses internet, telah dilakukannya lokmin bulanan dan triwulanan, serta adanya evaluasi kehadiran. Puskesmas diharapkan dapat menyiapkan aspek-aspek tersebut agar siap secara manajemen untuk menjalankan PIS-PK. Diharapkan Dinas Kesehatan Kabupaten/Kota dapat melakukan monitoring, evaluasi, supervisi dan bimbingan teknis program secara rutin kepada puskesmas.

Kata kunci: Manajemen puskesmas, pelatihan, PIS-PK
Deteksi Virus Dengue pada Nyamuk Aedes aegypti (Diptera: Culicidae) yang Tersebar di Kabupaten Sumba Timur dan Sumba Barat Daya
Authors: Noshirma Monika , Willa Ruben Wadu , Kazwaini Muhammad , Wibowo Arief
Published: October 2020

Abstract

Incidence Rate (IR) of Dengue fever in east and southwest Sumba district in 2015 amounted to 10.7‰ and 12.95‰ respectively. The phenomenon which is often found during this time is the transovarial transmission of the dengue virus in Ae. aegypti mosquitoes. The purpose of this research was to determine the presence of viral infections in Ae. aegypti mosquitoes through transovarial. It was a descriptive study with a cross-sectional design. The sample was an adult Ae. aegypti mosquito that is 8 to 10 days old. Dengue virus in mosquito body was checked by using immunocytochemical method Streptavidin Biotin Peroxidase Complex (ISBPC) at headsquash preparation. The resultshowed that the transovarial infection presence in male and female Ae. aegypti in East and Southwest Sumba District with Transovarial Infection Rate (TIR) in females and males ranging from 41.67%-41.92 and 25.00 – 50.00% respectively. The female and males mosquitoes TIR in East Sumba district were ranging from 20.00%-40.00% and 35.00%-40.00% respectively. East and Southwest Sumba districts are a high potential area for the transmission of dengue hemorrhagic fever with the presence of dengue virus in Ae. aegypti.

Abstrak

Incidence Rate (IR) Demam Berdarah Dengue di Kabupaten Sumba Barat Daya dan Kabupaten Sumba Timur pada tahun 2015 masing-masing sebesar 10,7‰ dan 12,95‰. Fenomena yang sering ditemukan selama ini adalah transmisi trans-ovari virus dengue pada nyamuk Ae. aegypti. Tujuan penelitian adalah untuk mengetahui adanya infeksi virus dengue pada nyamuk Ae. aegypti melalui trans-ovari. Penelitian ini merupakan studi deskriptif dengan desain potong lintang. Sampelnya adalah nyamuk Ae. aegypti dewasa yang telah berumur delapan sampai 10 hari. Pemeriksaan virus Dengue dalam tubuh nyamuk menggunakan metode Imunositokimia Streptavidin Biotin Peroxidase Complex (ISBPC) pada sediaan headsquash. Hasil penelitian infeksi virus dengue pada Ae. aegypti betina maupun jantan di Kabupaten Sumba Barat Daya menunjukkan adanya infeksi virus dengue melalui trans-ovari dengan Transovarial Infection Rate pada nyamuk betina berkisar antara 41,67% - 41,92, dan pada nyamuk jantan 25,00 – 50,00%. Transovarial Infection Rate di Kabupaten Sumba Timur pada nyamuk betina yang berkisar antara 20,00% - 40,00% dan pada nyamuk jantan 35,00% - 40,00%. Kesimpulannya Kabupaten Sumba Barat Daya dan kabupaten Sumba Timur merupakan daerah yang berpotensi untuk terjadinya penularan DBD dengan ditemukannya infeksi virus dengue pada nyamuk Ae. aegypti betina maupun jantan.
ANALISIS 3M PLUS SEBAGAI UPAYA PENCEGAHAN PENULARAN DEMAM BERDARAH DENGUE DI WILAYAH PUSKESMAS MARGAASIH KABUPATEN BANDUNG
Authors: Kurniawati Ratna Dian , Ekawati Ekawati
Published: October 2020

Dengue Haemorrhagic Fever (DHF) is an infectious disease that causes death. Bandung Regency experienced a trend of increasing the prevalence of DHF in the last three years of 2014-2016. Margaasih Primary Health Care was one of the endemic areas of DHF. One of the efforts to prevent and control disease transmission is the 3M Plus activity. The purpose of this study was to determine the relationship between 3M Plus activities with DHF incidence. The study design used observational with a cross-sectional approach. The population in this study was all households with a total of 6,988 families in Margaasih village. The sample of this research is 95 families. All data collection was conducted using a stratified random sampling technique. The bivariate test results showed the relationship between several 3M plus activities, such as draining water reservoirs, activities to close water reservoirs, recycle used items that can hold water, and the habit of hanging clothes with the incidence of DHF. While the installation of wire and the use of mosquito nets during sleep did not show a relationship with the DHF incidence.

 

 

 

Abstrak

Demam Berdarah Dengue merupakan penyakit menular yang menyebabkan kematian. Kabupaten Bandung mengalami tren peningkatan prevalensi DBD tiga tahun terakhir periode 2014-2016 dan Puskesmas Margaasih adalah salah satu daerah endemis DBD. Salah satu upaya pencegahan dan pengendalian terhadap penularan DBD adalah dengan kegiatan 3M Plus. Tujuan penelitian ini adalah mengetahui hubungan antara 3M Plus (menguras tempat-tempat penampungan air minimal seminggu sekali, menutup rapat-rapat tempat penampungan air, mendaur ulang barang bekas yang dapat menampung air, memasang kawat kasa, pemakaian kelambu saat tidur dan kebiasaan tidak menggantung pakaian di dalam rumah) dengan kejadian DBD. Desain penelitian menggunakan observasional dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh Kepala Keluarga yang berjumlah 6.988 KK di Desa Margaasih. Sampel penelitian ini berjumlah 95 KK. Teknik Pengambilan Sampel dengan stratified random sampling di RW 13 dan RW 5 Desa Margaasih. Hasil uji bivariat menunjukkan terdapat hubungan antara kegiatan menguras penampungan air, kegiatan menutup penampungan air, mendaur ulang barang-barang bekas yang dapat menampung air dan kebiasaan menggantung baju dengan kejadian DBD. Hasil berbeda ditunjukkan variabel pemasangan kawat dan pemakaian kelambu saat tidur, kedua variabel tersebut tidak memiliki hubungan dengan kejadian DBD.
What Will It Take to Recruit and Train More Underrepresented Minority Physicians in Family Medicine? A CERA Survey Analysis
Authors: Roulier Julia P. , Sung Jaeyun
Published: October 2020

Background and Objectives: Both the Society of Teachers of Family Medicine (STFM) and the American Academy of Family Physicians have developed strategic plans to increase the training of underrepresented minority in medicine (URMM) family physicians to meet the needs of an increasingly diverse patient population in the United States. This study examines data from the 2017 Council of Academic Family Medicine (CAFM) Educational Research Alliance (CERA) Program Directors (PD12) Survey to assess whether recruitment strategies increase the diversity of underrepresented minority physicians in family medicine.
Methods: Data were collected from an online electronic survey administered by the CERA of family medicine program directors in 2018. The data included specific questions about the diversity of URMM residents in family medicine programs and about initiatives that were used in their recruitment. We analyzed the data using the Pearson χ2 criteria for cause and effect of two variables.
Results: Family medicine residency programs that have initiatives dedicated to increasing resident diversity have a higher percentage of URMM residents. Specifically, residency programs that have URMM recruitment strategies are 2.5 to 4 times more likely to have a diverse residency population than those programs without strategies (P<.001-.015).
Conclusions: Striving to improve diversity in family medicine residency training in accordance with the ideals of STFM will require programs to design and implement initiatives to increase recruitment of URM residents.
BIBLIOMETRIC STUDY OF SCIENTIFIC PRODUCTION ON HANDBALL
Authors: Pardo Ibáñez Alberto , Madera Gil Joaquín , Pellicer Chenoll Maite
Published: October 2020

O objetivo deste estudo foi realizar uma análise bibliométrica da produção científica do handebol com estes objetivos: (1) caracterizar as publicações (2) analisar a produtividade, (3) identificar as áreas temáticas e as revistas de pesquisa e (4) apresentar as diferentes redes de co-ocorrência. A análise consistiu no cálculo de indicadores bibliométricos básicos e foi realizada uma análise de co-ocorrência para estabelecer as relações entre autores, entre citações de artigos científicos e entre palavras-chave de autores. Foram analisados 1637 artigos originais e 90 revisões em 399 revistas. Um total de 4752 autores assinaram artigos relacionados ao termo handebol. Os principais tópicos foram "handball" e "ACL", e encontramos uma tendência nos últimos anos em aumentar a presença de artigos da área de treinamento.
PADRONIZAÇÃO DA UTILIZAÇÃO DE EMBALAGEM EM UMA EMPRESA DE MEDIDORES DE ENERGIA POR MEIO DAS FERRAMENTAS DA QUALIDADE
Authors: Silva Franscisco Evangelista da , Loos Mauricio Johnny
Published: October 2020

Em um mercado cada vez mais competitivo, as organizações vêm buscando reduzir o custo de fabricação de seus produtos e serviços prestados, através do aperfeiçoamento de seus processos, eliminando atividades que não acrescentar valor ao produto, identificando os gargalos e solucionando suas causas raízes. A utilização de determinadas técnicas e ferramentas da qualidade tornou-se um mecanismo indispensável para as organizações, na busca pela solução de problemas e melhoria contínua dos processos organizacionais. Neste contexto, este artigo tem como objetivo demonstrar um trabalho realizado em uma empresa fabricante de medidores de energia, onde foi possível padronizar a utilização de embalagens por meio das ferramentas da qualidade. Além da padronização das embalagens, através deste trabalho foi possível reduzir as variedades de itens de embalagens, diminuir o dead stock no almoxarifado, melhorar o gerenciamento dos itens na produção e aumentar o poder de barganha na compra de embalagens. Todas essas melhorias favoreceram para a redução do custo dos produtos e tornar a empresa mais competitiva no mercado.
Volver a la Pedagogía
Authors: Prieto Castillo Daniel
Published: October 2020

La propuesta de mediación pedagógica, que desarrollamos con nuestro recordado Francisco Gutiérrez Pérez surgió en dos universidades guatemaltecas en los últimos años de la década de 1980, en el marco de un sistema en modalidad a distancia. Ambos veníamos de un largo trabajo en el campo de la comunicación y la educación tanto en espacios comunitarios y populares como en sistemas de enseñanza formal.
Pengaruh Media Perebusan Terhadap Komposisi Mineral Kerang Air Tawar Meti (Batissa violacea Lamarck, 1818)
Authors: Handayani Kiki Rizki , Yuyun Yonelian , Jamaluddin
Published: October 2020

This research aims were to analyzed mineral composition of fresh and processed meti freshwater mussels (Batissa violacea Lamarck,1818) and to know the effect of boiling media on the mineral composition with various added boiling media conditions that are water, NaCl 1%, and acetic acid 0.5%. Mineral compositions were tested with microwave digestion and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) method. Mineral composition of fresh mussel were consisted of calcium (Ca) 10412 mg/kg, cobalt (Co) 0,182 mg/kg, copper (Cu) 3,54 mg/kg, magnesium (Mg) 345 mg/kg, mangan (Mn) 13,6 mg/kg, phosphor (P) 7753 mg/kg, potassium (K) 1163 mg/kg, sodium (Na) 291 mg/kg, and zinc (Zn) 44,2 mg/kg. The results of research on freshwater mussels in boiling media of water, NaCl 1%, and acetic acid 0.5% gave effect on the levels of minerals of calcium (Ca), magnesium (Mg), phosphor (P), potassium (K), sodium (Na ), cobalt (Co), copper (Cu), mangan (Mn) and there is no effect on the levels of zinc (Zn).
State-owned enterprises’ corporate governance: Evidence from a Portuguese company
Authors: Vicente Joana Andrade
Published: October 2020

This paper analyses state-owned enterprises’ (SOEs) corporate governance, addressing whether there are differences between these and private enterprises that make it necessary to formulate a specific corporate governance theory for the former. This will be achieved through a case study based on Carris company, mitigating the lack of empirical knowledge in this field and taking a step forward by clearly proving what it is suggested by the literature: SOEs’ governance particularities actually influence their day-to-day business and financial viability. That helps to highlight the urgency to apply adequate corporate governance techniques to SOEs, more aligned with their characteristics. SOEs have a different legal status, more volatile operating goals, soft budget constraints, lack of public service contracts (and consequent mismatch of the corresponding compensatory allowances due for the public service provided), and different criteria for professional appointment and selection. More importantly, they suffer from multiple principals’ phenomenon: multiple principals, multiple problems. It is, therefore, recommended some changes regarding their corporate governance, such as the incorporation of the comply-or-explain principle; introduction of a code of best practices in the public managers’ appointment process; and contractual arrangements regarding the public service provided, with the multiannual allocation of the corresponding compensatory allowances.
ELECTROSPUN PROTEIN NANOFIBERS AND THEIR FOOD APPLICATIONS
Authors: İNCE YARDIMCI Atike , TARHAN Özgür
Published: October 2020

Electrospun nanofibers with their large surface area, high porosity, small pore sizes, and ability of the high loading of active agents possess many structural and functional advantages for food applications. Proteins play significant roles in physicochemical and structural properties in foods. There has been a great interest in using proteins for the fabrication of nanofibers through electrospinning technique. Due to their molecular weight, most of the proteins are non-spinnable alone however; their spinnability can be enhanced by the incorporation of food-grade biocompatible polymers. In this review, the basics of the electrospinning technique were introduced first, followed by detailed information about electrospun nanofibers formed using plant and animal proteins. Common polymers blended with proteins to enhance their spinnability were also discussed. It the last part, the use of electrospun nanofibers in various food applications such as encapsulation of bioactive components, enzyme immobilization, and food packaging was emphasized.
Influence of sodium valproate treatment on body mass and insulin resistance parameters in children with epilepsy
Authors: Dimitrijevic Aleksandar , Stojanovic Radan , Bogicevic Dragana , Mitic Vesna , Nikolic Dimitrije
Published: October 2020

Introduction/Objective. One of the main side effects in patients undergoing valproic acid treatment is weight gain, which might be the reason for drug discontinuation, especially in adolescent girls, and it also has to be considered before introducing the drug. The main goal of our study is to investigate a possible influence of antiepileptic therapy with sodium valproate on weight and glucose homeostasis in pediatric patients with epilepsy. Methods. The investigation included 49 healthy children with recently diagnosed epilepsy. We measured height, weight, and serum 12-hour overnight fasting glucose and insulin level before initiation and after six- and 12-month valproic acid treatment periods. The body mass index and homeostasis model assessment indexes were calculated for each patient and correlated after the initiation of therapy and after six and 12 months of therapy. Results. We found that children significantly gained weight with statistical significance (p < 0.01) even after six months of therapy with a significant glucose metabolism change and statistical difference in average serum glucose and insulin levels (p < 0.05). Conclusion. Our results show that a 12-month treatment with valproic acid in children with epilepsy has a great impact on weight gain and glucose homeostasis and metabolism. We strongly recommend that all children with recently diagnosed epilepsy at the initiation of valproate therapy should be closely monitored on a six-month basis. Consultations with a nutritionist is advised especially in children with a preexisting body weight problem.
Correction of post-traumatically scarred upper lip with hyaluron filler
Authors: Ivanjac Filip , Radenkov Tanja
Published: October 2020

Introduction. It is generally known that dermal fillers are widely used in anti-aging medicine, to provide volume in healthy skin and mucous tissue. Fillers can also be successfully used with concave scars in order to lift the tissue and to give third dimension to the retracted skin surface. The aim of this case report was to show successful non-surgical treatment with hyaluron filler of the post-traumatically deformed upper lip. Case outline. We report a case of a woman with asymmetric partly incompetent upper lip, after trauma and primary surgical reconstruction. After almost 12 years, reconstruction with hyaluron filler was performed, using linear retrograde and bolus technique. Conclusion. Presented case correction of the posttraumatic scar of the upper lip illustrates that good aesthetic results could be achieved with hyaluron fillers.
The Impact of Empagliflozin on Obstructive Sleep Apnea and Cardiovascular and Renal Outcomes: An Exploratory Analysis of the EMPA-REG OUTCOME Trial
Authors: Neeland Ian J. , Eliasson Bjorn , Kasai Takatoshi , Marx Nikolaus , Zinman Bernard , Inzucchi Silvio E. , Wanner Christoph , Zwiener Isabella , Wojeck Brian S. , Yaggi Henry K. , Johansen Odd Erik
Published: October 2020

OBJECTIVE

To explore the effects of empagliflozin on the incidence of obstructive sleep apnea (OSA) and its effects on metabolic, cardiovascular (CV), and renal outcomes among participants with or without OSA in the EMPA-REG OUTCOME trial.

RESEARCH DESIGN AND METHODS

Participants with diabetes and CV disease were randomized to empagliflozin (10 and 25 mg) or placebo daily in addition to standard of care. OSA was assessed by investigator report using Medical Dictionary for Regulatory Activities version 18.0, and CV outcomes were independently adjudicated. Analyses were performed using multivariable-adjusted Cox regression models.

RESULTS

OSA was reported in 391 of 7,020 (5.6%) participants at baseline. Those with OSA were more likely to be male (83% vs. 71%) and to have moderate to severe obesity (BMI ≥35 kg/m2; 55% vs. 18%). Over a median of 3.1 years, empagliflozin had similar placebo-adjusted reductions in HbA1c, waist circumference, and systolic blood pressure, regardless of OSA status, but a larger effect on weight (adjusted mean ± SE difference at week 52: OSA vs. no OSA −2.9 ± 0.5 vs. −1.9 ± 0.1 kg). Incidence of 3-point major adverse CV events, CV death, heart failure hospitalization, and incident or worsening nephropathy in the placebo group was 1.2- to 2.0-fold higher for those with baseline OSA compared with those without. Empagliflozin significantly reduced the risk for outcomes regardless of OSA status (P-interaction all >0.05). Fifty patients reported a new diagnosis of OSA through 7 days after medication discontinuation, and this occurred less often with empagliflozin treatment (hazard ratio 0.48 [95% CI 0.27, 0.83]).

CONCLUSIONS

In EMPA-REG OUTCOME, participants with OSA had greater comorbidity and higher frequency of CV and renal events. Empagliflozin had favorable effects on risk factors and CV and renal outcomes regardless of preexisting OSA and may also reduce the risk for new-onset OSA.
A Comparative Study of Deixis Used by Foreign and Local English Teachers in Vocational High School
Authors: Mayori Winda , Adi Jaya Putra Nyoman , Suarnajaya I Wayan
Published: October 2020

This study aims to analyze the types of deixis by using Levinson’s theory, find out the dominant types of deixis, and the reasons behind the uses of deixis by foreign and local English teachers. The study used a qualitative method particularly a case study. The data sources of this study were the foreign and local English teachers’ utterances. The data were obtained through a classroom observation and interview technique. The data were analysed using Miles and Hubermans’s interactive model. The findings showed that five types of deixis were found in the foreign and local English teacher’s utterances, namely person deixis, place deixis, time deixis, discourse deixis, and social deixis. The dominant types of deixis in both the English teachers’ utterances were person deixis.  The reasons behind the uses of deixis were also explained in this study
Pesma Apps as Android-based Integrated Applications for Mahasantri Pesma KH Mas Mansur UMS
Authors: Khafid Bisrul , Putri Devi Afriyantari Puspa
Published: October 2020

Pesantren Mahasiswa Internasional KH Mas Mansur (Pesma) has a shuttle facility for everyone who lives there. However, the use of the shuttle is not optimal because the ordering procedure still uses manual techniques. It contrasts with the rapid development of industry 4.0 and the mission of Pesma to get digitalization. This paper describes the effort to improve Pesma shuttle bookings by developing an application. The application is built upon the Android Studio 3.5.1 platform and uses Firebase real-time database. The development method implements the System Development Life Cycle (SDLC), Waterfall. The research results in an application called “Pesma Apps” that can be used by staff and mahasantri. Testing the Pesma apps, we obtained sufficiently good results where the black box testing proves that all functions work well. A usability testing using SUS with 30 respondents produces a good result at the level of 72.6, which suggests that the application is accepted.
Intake, gain and carcass traits of Hereford and Charolais bulls offered diets based on triticale, barley and grass silages
Authors: Huuskonen Arto Kalevi , Jaakkola Seija , Manni Katariina
Published: October 2020

Total mixed rations (TMR) based on grass silage (GS), triticale silage (TS), mixture of GS and TS, barley silage (BS) and mixture of GS and BS were fed to fifty Hereford (HF) and fifty Charolais (CH) bulls. The proportion (g kg-1 dry matter [DM]) of the silages in the TMRs were as follows: (1) GS (600); (2) TS (600); (3) GS (300) and TS (300); (4) BS (600); (5) GS (300) and BS (300). Concentrate proportion was 400 g kg-1 DM. According to feed analyses, the GS had 15 and 8% higher metabolizable energy (ME) concentration as well as 51 and 49% higher crude protein (CP) concentration compared to TS and BS, respectively. Average DM intake (DMI) on TS and BS containing diets was higher compared to GS as a sole forage (p=0.001). Compared to the TS based rations the use of BS rations increased daily DMI by 5% (p<0.05). In CH bulls, DMI decreased 0.8 kg d-1when GS partially replaced TS or BS while in HF bulls the use of silage mixtures slightly increased DMI (0.23 kg d-1). The live weight gain (LWG) and carcass gain of the CH bulls were 5 and 26% higher, respectively, compared to the HF bulls. Inclusion of GS in the diet increased LWG and carcass gain with TS but decreased them with BS (interaction p<0.01). The experiment demonstrated lower feeding value of TS compared to BS in the diet of the bulls. Whole crop silage based rations increased DMI compared to GS as a sole forage in the TMR. When GS partially replaced TS or BS, interactions in LWG and carcass gain results demonstrated higher feeding value for BS and lower for TS compared to GS. Feeding treatments had only minor effects on carcass traits of the bulls.
Persepsi Siswa Sekolah Menengah Atas (SMA) terhadap Perpustakaan Proklamator Bung Hatta Bukittinggi
Authors: Putra Agung Dwino , Nelisa Malta
Published: October 2020

Abstract The purpose of this research are (1) find out how the perceptions of high school students towards the librarians of the Bung Hatta Proclamator Library. (2) find out how the perceptions of senior high school students to the collection of Bung Hatta Proclamator Library. (3) knowing how perceptions of senior high school students to the services of Bung Hatta's Proclamator Library. (4) knowing the perceptions of high school students on Bung Hatta Proklamator Library facilities.Keywords: Perceptions, Students, Bung Hatta's Proclamator Library
Persepsi Pegawai Unit Kearsipan SKPD terhadap Aplikasi Sistem Informasi Kearsipan Daerah (SIKEDA) dan Jaringan Informasi Kearsipan Daerah (JIKEDA) di Pemerintahan Kota Bukittinggi
Authors: Suherman Agus , Ardoni Ardoni
Published: October 2020

AbstractIn this paper we discuss the SKPD Filing Unit Employee Perception of the Regional Archival Information System Application (SIKEDA) and the Regional Archival Information Network (JIKEDA) in  the City Government of Bukittinggi. The purpose of this study is to determine the competence and optimal shield of SKPD employees in inputting files to the SIKEDA application.This type of research is descriptive research with a qualitative approach. The location of this study was carried out in 5 SKPD Institutions in Bukittinggi, namely: (1) the Library and Archives Office of Bukittinggi City, (2) the Education and Culture Office of the City of Bukittinggi, (3) the Youth and Sports Pariwasata Service of the City of Bukittinggi, (4) the Health Service City of Bukittinggi, (5) Social Service of the city of Bukittinggi. The object of the study was SKPD employees in five government agencies in the city of Bukittinggi. Writing this paper aims to describe (1) To describe the optimization of the use of SIKEDA and JIKEDA applications by Admin node SIKEDA in supporting records management in the city administration of the City of Bukittinggi; (2) To describe the competencies possessed by HR in SKPD in utilizing information technology in the application of SIKEDA and JIKEDA applications in the City Government of Bukittinggi.Data was collected by observation and direct interviews with SKPD employees in the Bukittinggi city government and literature studies in the application of electronic records in the government of the City of Bukittinggi.Based on the discussion, it can be concluded that the First Employee in the SKPD in the City Government of Bukittinggi is still not optimal in inputting the archive to the sikeda Second application.iKeywords: optimization, competence, electronic archives.
Sistem Alih Media pada Koleksi Khusus Bung Hatta di UPT Perpustakaan Proklamator Bung Hatta Bukittinggi
Authors: Putra Aldo Maha , Desriyeni Desriyeni
Published: October 2020

Abstract The writing of this paper aims to explain the process of media transfer in the special collection of Bung Hatta and find out the obstacles that occur in the process of media transfer in the special collection of Bung Hatta and to know the efforts to overcome the obstacles in the process of media transfer in the special collection of Bung Hatta in the Bung Hatta Library Proclamation Unit. This type of research is descriptive in nature, which wants to describe the activities of digital media transfer as an effort to preserve the special collection of Bung Hatta at the Bung Hatta Library Proclamation Unit. Data collection techniques through direct observation to the location and interviews and data collection by reading and studying sources in the form of books, literature, and literature studies. Based on the processed data it can be concluded that. First, the process of media transfer activities at the Bung Hatta special collection at the Bung Hatta Library was carried out in three stages, namely: (a) the process of taking pictures (b) the editing process, and (c) the process of packaging the book for media transfer. Second, the obstacles that occur in the process of media transfer in the special collection of Bung Hatta in the Bung Hatta Proclamator Library are: (a) facilities and infrastructure that are still inadequate, (b) lack of expertise in carrying out media transfer activities in the Bung Hatta special collection, and (c) media transfer activities have not been included in the library budget. Third, the efforts made to overcome the obstacles in the process of media transfer at the special collection of Bung Hatta at the Bung Hatta Library Proclamation Unit UPT are: (a) completing facilities and infrastructure to support media transfer activities as well as preparing special rooms that are impermeable to light, (b) adding energy experts and also conduct training for other staff, and (c) incorporate media transfer activities into the library budget so that these activities run optimally and sustainably. Keywords: Transferring Media, Bung Hatta's Special Collection
Pembuatan Direktori Lokasi Bermain Skateboarding di Sumatera Barat
Authors: Putra Dian Mega , Desriyeni Desriyeni
Published: October 2020

AbstractWriting this paper aims to create a directory of locations for skateboarding in West Sumatra. The method used in this paper is descriptive research, which examines a group of people, an object, a condition, a thought, or a class of events in the present. Data collection is done by observation, interview, and literature study. Based on data analysis, it can be concluded as follows. First, the obstacles in making a skateboarding directory location in West Sumatra can be described as follows. (a) the writer has difficulty finding a clear place about the location of skateboarding. These constraints are due to the absence of a clear pointer or direction to a skateboarding location. (b) the distance from the downtown or downtown. These constraints are due to inadequate access to locations. The author must ask and explain to the surrounding community in detail in a location in order to get to the point where to skateboard. (c), the authors find it difficult to find the right sources for more detailed information on a skateboarding location. The existence of these obstacles is due to ignorance of the community and skateboarding community about the place. The author only gets some clear information when making observations. Second, the author's attempt to do so is as follows. (a) the author does his best to make clear road and road directions to a skateboarding location with the help of the surrounding community and the communities in the place. With the help of the community and community in making instructions at a predetermined point or better known by the community. (b) the author tries to minimize the distance to the location of skateboarding by asking the informant or the right informant at a skateboarding location. (c) the author tries his best to do interviews with several people to get clear and precise information about a skateboarding location. The resource person can come from the community itself or the community around the location.Keywords: directory, skateboarding, West Sumatera
Pembuatan Direktori Sanggar Tari di Kota Padang
Authors: Rusmaidi Indah , Desriyeni Desriyeni
Published: October 2020

AbstractThis paper discusses the Making of a Dance Studio Directory in the City of Padang. The purpose of this paper is (a) to describe the making of a directory of dance studios in the city of Padang; (B) describing the transition in creating a directory of dance studios in Padang City; (c) describe the business in making a directory of dance studios in the city of Padang. This research was conducted using descriptive methods by describing the subject or object based on visible facts. Data collected through observation, interviews, and literature study. Based on the research that has been done, it can be concluded, first, the steps in the process of making dance studios in the city of Padang are (a) data collection that collects all information relating to which is not in doubt to be made in the directory; (B) collect all data obtained; (c) Focus on a vision that has been created; (d) making books so that they are easier to produce and making books more directed; (e) determine the subject, the subject used in making the directory is the name of the street, location of each studio; (f) classification or grouping, grouping data that has been collected and adjusted to the subjects that have been determined; (g) directory design that is by making cover designs, and compiling information from directories. Second, the challenges involved in making a dance studio directory in Padang City are as follows: (a) when collecting data the writer had difficulty in finding the dance studio to be addressed. This is because there are some studios that do not have banners or name bars installed. Discusses some problems in finding the studio; (B) some studios that the author visits the owner often go to the studio or the owner is out of town because they have to accompany their students in the race; (c) difficulties in contacting the studio owner. Third, the non-related ones involved in making directories include; (a) the name of the studio; (b) the name of the owner; (c) year of establishment; (d) number of students; (e) hours of practice; (f) address; (g) telephone number; (h) location plan; and (i) studio photos.Keywords: Manufacture, Directory, Dance Studio
Strategi Pustakawan dalam Pemanfaatan Perpustakaan Oleh Siswa di SMA Negeri 1 Lubuk Alung Kabupaten Padang Pariaman
Authors: Putri Ningsih Ramayana , Ardoni Ardoni
Published: October 2020

AbstractThis paper discusses the Strategy of Librarians in the Use of Libraries by Students in Lubuk Alung 1 High School in Padang Pariaman Regency. The purpose of this paper is to describe the Strategy of Librarians in the Use of Libraries by Students in Lubuk Alung 1 High School in Padang Pariaman Regency. This research was conducted using descriptive methods through a qualitative approach. Data was collected through literature studies, observations and direct interviews with the Head of Library of SMA Negeri 1 Lubuk Alung, Padang Pariaman Regency. Based on the discussion in the previous chapter, it can be concluded that the Librarian's Strategy in Library Utilization by Students in Lubuk Alung 1 High School in Padang Pariaman Regency is as follows: (a) require students to become members of the library and borrow textbooks; (b) providing collections that are in accordance with the curriculum; (c) collaborating with other libraries in meeting collection needs; (d) do not apply penalties for returning late books; (e) make outdoor reading rooms; (f) creating a class library; (g) conducting tutoring activities; (h) provide virtual library services; (i) provide audiovisual services; (j) provide supporting services; and (k) organizing competitions and giving awards to students.Keywords: Strategies, Librarians, Library Utilization
Perilaku Pencarian Informasi Mahasiswa Jurusan Teknologi Pendidikan Tahun 2016 di Perpustakaan Universitas Negeri Padang
Authors: Ramadanti Novya
Published: October 2020

AbstractThis paper discusses the 2016 information seeking behavior of Education Technology Department students at the Padang State University Library. The purpose of writing this paper is to describe: (1) information seeking behavior of 2016 Education Technology students at the Padang State University Library; (2) obstacles in conducting information searches at the Padang State University Library; (3) efforts that can be made to overcome obstacles in conducting information searches at the Padang State University Library. Data collection is done through questionnaires or questionnaires. Based on the results of the study concluded as follows: (1) information seeking behavior of Education Technology Department students in 2016 from the front information seeking behavior of students gave a positive response, (2) obstacles encountered in conducting information searches among them: (a) no information they need ; (b) the incomplete collection needed; (c) there are difficulties in finding collections because they are on different shelves than the OPAC system; (d) inadequate internet network; (e) the service of librarians who are unfavorable and unwise, (3) efforts that can be made to overcome obstacles in seeking information are: (a) providing and completing collections according to the needs of students and lecturers; (b) compile a collection rack that is compatible with the OPAC search engine, so that users can easily find the information they need; (c) improving internet network facilities so that they are not slow, because most students often use the internet to find information they need; (d) as a librarian, it is better to serve the user well and wisely so that they can help the users who find it difficult to find the information needed.Keywords: behavior, information, students, librarians.
Pembuatan Indeks Beranotasi Surat Kabar Terbitan Sumatra Barat tentang Kebudayaan Minangkabau
Authors: Fahrulrozi M Ikhsan , Ardoni Ardoni
Published: October 2020

Abstract The library at the Padang City Library and Archives Service is one of the libraries that provides services for users. Index is a tool to retrieve information quickly and accurately, with the index user can easily find information when needed without the need to read the entire contents of newspaper articles. In accordance with the needs of users related to information, we need more complex information tracking tools such as annotated indexes of newspaper articles. One means of tracing information by subject is the subject of Minangkabau culture. Users who need information about Minangkabau culture will find it easier to find that information through an index search tool.Keywords: Annotated Index of Newspapers Published in West
Penelusuran Informasi Lulusan Program Studi Pendidikan Bahasa Indonesia Fakultas Bahasa dan Seni
Authors: Tusya'diah Delima , Rahmah Elva
Published: October 2020

AbstractShearch for information on graduates of Indonesian Language Study Programs a the Faculty of Language and Art. Paper. Library and Archives Information Study Program, Indonesia dan Regional Language and Literature Departement, Language and Art Faculty, Padang State University. In this paper we discuss the search for graduates of the UNP Language and Arts Faculty of Indonesia Language Study Program. The purpose of this study was to determine the profile of Indonesia Education Study Program graduates and to know the competency and employment of these graduation. The research method approach used is a qualitatif method. Data was collected using questionnaires. The location of this study was carried out on the application or distributing questionnaires through social media. The object of the search was the Inodesian Language Education alumni who responded to 47 alumni. The data collection technique was by sharing questionnaires through WhatsApp media. Analyze the data used by using the google form application. First based on the results of the study, concluded the following matters. Graduates of the Indonesian Language Study program every year do not settle or go up and down, many respondents are among women with the dominant year of entry in 2014, the lenght of the waiting period for employment before graduation 1-3 months while their first job is < 3 months. The two Indonesian Language Education alumni are mostly looking for work through the internet, the level, and they work in the education sector, both private and obtain the first salary of RP. 1.000.000 and the first salary of Rp. 1.000.000- IDR 2.000.000.Keyword: search; education; alumni