bluuebunny/crossref_metadata_2025 huggingface dataset:
Joint inversion with petrophysical constraints using indicator functions and the extended alternating direction method of multipliers
Authors: Wang Ke , Yang Dikun
Published: October 2022

Joint inversions often need to construct an objective function with multiple complex constraining terms, which usually increase the computational cost, take a long time to converge, and often are nondifferentiable. We have developed a joint inversion framework that implements petrophysical constraints by indicator functions and solves the optimization problem using the alternating direction method of multipliers (ADMM). An indicator function can describe arbitrary ranges and relationships of multiple physical property parameters by a feasible set. Objective functions involving multiple nondifferentiable terms are numerically not easy to solve, so we adopt an extended alternating direction method of multipliers (eADMM) that separates the terms as independent subproblems and select the most straightforward and efficient solving technique for each of them. With the eADMM, every objective function term can generate its own model, and the models are forced to converge through equality constraints. Such a mechanism brings further efficiency from parallelization and the flexibility of allowing the final inversion model to not strictly obey the model constraints because of uncertainties in the data and petrophysical information. Our approach is tested on two synthetic examples of joint inversion of gravity and magnetic data. The first example contains two blocks having the same magnetic susceptibility but different densities. Our synthetic inversions verify that the combination of the indicator function and eADMM method effectively recovers exact boundaries and values. The second example uses the data synthesized from a realistic kimberlite exploration project. Our joint inversion can distinguish two kimberlite facies, image their position, and even delineate the boundary between the two facies with much improved accuracy. Based on the same model, the robustness of our method also has been tested with inexact and incorrect petrophysical information. The simplicity, flexibility, effectiveness, and efficiency make our approach a good candidate for a wide range of applications in joint inversion.
Learning stochastic filtering
Authors: Ramakrishnan Rahul O. , Auconi Andrea , Friedrich Benjamin M.
Published: October 2022

We quantify the performance of approximations to stochastic filtering by the Kullback-Leibler divergence to the optimal Bayesian filter. Using a two-state Markov process that drives a Brownian measurement process as prototypical test case, we compare two stochastic filtering approximations: a static low-pass filter as baseline, and machine learning of Volterra expansions using nonlinear Vector Auto-Regression (nVAR). We highlight the crucial role of the chosen performance metric, and present two solutions to the specific challenge of predicting a likelihood bounded between 0 and 1.
Survivin: A Potential Marker of Resistance to Somatostatin Receptor Ligands
Authors: Herkenhoff Clarissa G Borba , Trarbach Ericka B , Batista Rafael Loch , Soares Iberê Cauduro , Frassetto Fernando Pereira , do Nascimento Felipe Barjud Pereira , Grande Isabella Pacetti Pajaro , Silva Paula P B , Duarte Felipe H G , Bronstein Marcello D , Jallad Raquel S
Published: October 2022

Context

Invasive and somatostatin receptor ligand (SRL)-resistant pituitary tumors represent a challenge in the clinical practice of endocrinologists. Efforts have been made to elucidate reliable makers for both. Survivin and eukaryotic translation initiation factor-binding protein 1 (4EBP1) are upregulated in several cancers and involved in apoptosis and cell proliferation.

Objective

We explored the role of these markers in somatotropinomas.

Methods

Immunostains for survivin and 4EBP1, and also for somatostatin receptor type 2 (SSTR2), Ki-67, and cytokeratin 18, were analyzed in tissue microarrays containing 52 somatotropinoma samples. Tumor invasiveness was evaluated in all samples while drug resistance was evaluated in 34 patients who received SRL treatment. All these parameters were correlated with first-generation SRL (fg-SRL) responsiveness and tumor invasiveness.

Results

Low survivin expression (P = 0.04), hyperintense signal on T2 weighted image (T2WI) (P = 0.01), younger age (P = 0.01), sparsely granular adenomas (SGA) (P = 0.04), high postoperative growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels (P = 0.049 and P < 0.001, respectively), and large postoperative tumor size (P = 0.02) were associated with resistance to fg-SRL. Low survivin and SSTR2 expression and high 4EBP1 expression were associated with SGA (P = 0.04, P = 0.01, and P = 0.001, respectively). Younger age (P = 0.03), large tumor pre- and postoperative (P = 0.04 and P = 0.006, respectively), low SSTR2 expression (P = 0.03), and high baseline GH and IGF-1 (P = 0.01 and P = 0.02, respectively) were associated with tumor invasiveness. However, survivin, 4EBP1, Ki-67, and granulation patterns were not associated with tumor invasion.

Conclusion

This study suggests that low survivin expression is predictive of resistance to fg-SRL in somatotropinomas, but not of tumor invasiveness.
The CRL4 E3 ligase Mahjong/DCAF1 controls cell competition through the transcription factor Xrp1, independently of polarity genes
Authors: Kumar Amit , Baker Nicholas E.
Published: October 2022

Cell competition, the elimination of cells surrounded by more fit neighbors, is proposed to suppress tumorigenesis. Mahjong (Mahj), a ubiquitin E3 ligase substrate receptor, has been thought to mediate competition of cells mutated for lethal giant larvae (lgl), a neoplastic tumor suppressor that defines apical-basal polarity of epithelial cells. Here, we show that Drosophila cells mutated for mahjong, but not for lgl [l(2)gl], are competed because they express the bZip-domain transcription factor Xrp1, already known to eliminate cells heterozygous for ribosomal protein gene mutations (Rp/+ cells). Xrp1 expression in mahj mutant cells results in activation of JNK signaling, autophagosome accumulation, eIF2α phosphorylation and lower translation, just as in Rp/+ cells. Cells mutated for damage DNA binding-protein 1 (ddb1; pic) or cullin 4 (cul4), which encode E3 ligase partners of Mahj, also display Xrp1-dependent phenotypes, as does knockdown of proteasome subunits. Our data suggest a new model of mahj-mediated cell competition that is independent of apical-basal polarity and couples Xrp1 to protein turnover.
Διαφορική έκφραση καρκινικών δεικτών σε παθήσεις του πνεύμονα
Authors: Κυρίτσης Αθανάσιος
Published: October 2022

Η πλειονότητα των microRNAs μεταγράφεται από την πολυμεράση ΙΙ του RNA και συντίθενται τα πρωταρχικά μετάγραφα miRNA (pri-miRNAs), τα οποία αποκτούν 5΄καλύπτρα και 3΄ πολυ(Α) ουρά. Σύμφωνα με το ισχύον μοντέλο της μεσολαβούμενης από miRNAs γονιδιακής σίγησης, τα ώριμα miRNAs στρατολογούν ένζυμα γνωστά ως απαδενυλάσες που καταλύουν το πρώτο και συχνά καθοριστικότερο βήμα στην αποικοδόμηση των mRNA-στόχος, δηλαδή τη βράχυνση της ουράς πολυ(Α). H πολυ(Α) εξειδικευμένη ριβονουκλεάση (PARN), το καλύτερα χαρακτηρισμένο μέλος της υπεροικογένειας των DEDD αποαδενυλασών, εμπλέκεται εκτός των άλλων στα όψιμα στάδια ωρίμανσης αρκετών μη-κωδικών μορίων RNA. Στην παρούσα διατριβή, αρχικά δείχνουμε πως η PARN επιδρά στα επίπεδα έκφρασης μιας υποομάδας miRNAs σε κύτταρα NCI-H520, προερχόμενα από πλακώδες καρκίνωμα πνεύμονα. Ενδιαφέρον παρουσιάζει το γεγονός πως μεταξύ των απορυθμισμένων miRNAs, συγκαταλέγονται τα miR-29a και miR-1207, τα οποία φέρονται να στοχεύουν την 3΄ αμετάφραστη περιοχή του mRNA της PARN, σύμφωνα με τα δεδομένα που ανακτήθηκαν από in silico προγράμματα πρόβλεψης. Ακολούθως, δείχθηκε πως η PARN κατακρημνίζεται με επιλεγμένα pri-miRNAs και ρυθμίζει την κατάσταση πολυαδενυλίωσης τους. Σε μια προσπάθεια ταυτοποίησης παραγόντων που θα μπορούσαν να στρατολογούν την PARN στα πολυαδενυλιωμένα pri-miRNAs-στόχος, δείξαμε πως ο παράγοντας τμήσης και πολυαδενυλίωσης 6 (CPSF6), η μεγαλύτερη υπομονάδα του συμπλόκου CFIm, αλληλεπιδρά με την PARN και από κοινού επηρεάζουν τα επίπεδα έκφρασης τόσο των πρωταρχικών όσο και των ώριμων μορφών των εξεταζόμενων miRNA-29a και miRNA-1207. Aπό την άλλη, σύμφωνα με τα αποτελέσματα δοκιμασίας λουσιφεράσης, τα προαναφερθέντα miRNAs στοχεύουν την 3΄UTR του mRNA της PARN και ρυθμίζουν την έκφραση της. Ακολούθως, δείχθηκε πως διατάραξη των επιπέδων έκφρασης της PARN και των υπό μελέτη miRNAs, επηρεάζει την μεταναστευτικότητα κυττάρων NCI-H520. Τέλος, προτείνουμε ένα μοντέλο το οποίο περιγράφει τη δυναμική σχέση μεταξύ της PARN και του miR-29a-3p και επιχειρούμε να τονίσουμε τη βιολογική σημασία αυτής.
Η διαπίστωση της αγιότητας αυτοκρατόρων και μελών αυτοκρατορικών οικογενειών στο Βυζάντιο από τον 4ο έως τον 10ο αιώνα
Authors: Νικολόπουλος Χρήστος
Published: October 2022

Η διατριβή μου ασχολείται με τους αυτοκράτορες ή τα μέλη των αυτοκρατορικών οικογενειών μίας συγκεκριμένης βυζαντινής περιόδου (4ος - 10ος αι.) που αναφέρονται σε διάφορα αγιολόγια, συναξάρια, μηναία ή άλλα αγιολογικά κείμενα της βυζαντινής ή μεταγενέστερης περιόδου. Τα πρόσωπα είναι πολλά. Το Συναξάριο της Κωνσταντινούπολης (Ι΄ αι.) αναφέρει δεκάδες αυτοκρατορικά πρόσωπα. Άλλα συναξάρια ή μηναία της βυζαντινής περιόδου αναφέρονται σε περισσότερα ή λιγότερα πρόσωπα. Σε αυτά θα πρέπει να προστεθούν και τα πρόσωπα εκείνα που αναφέρονται μόνο σε νεότερα αγιολογικά κείμενα (π.χ. του 20ου αι.). Γιατί λοιπόν κάποια αγιολογικά κείμενα αναφέρουν αυτά τα πρόσωπα; Ποιοί ήταν οι λόγοι που προχώρησαν σε αυτήν την αναφορά; Μπορούμε να καταλήξουμε σε ένα μοτίβο;
Recent advances on dimensionality reduction for high-dimensional data analysis with applications
Authors: Ντότσης Κίμων
Published: October 2022

Μεγάλης κλίμακος ακατέργαστα δεδομένα μπορεί να αποτύχουν στην ορθή επιλογή και εκτίμηση ενός μοντέλου, γεγονός που συχνά αποδίδεται στην ύπαρξη πολυσυγγραμμικότητας μεταξύ των μεταβλητών, και γι' αυτό συστήνεται η προεπεξεργασία των δεδομένων ώστε να επιτευχθεί καλύτερη μοντελοποίηση και οπτικοποίηση. Για την αντιμετώπιση της τροχοπέδης που δημιουργούν τα ακατέργαστα δεδομένα, μεταξύ άλλων δυσκολιών, αναπτύχθηκαν οι Τεχνικές Μείωσης Διάστασης σε μια προσπάθεια να μετριαστεί το μέγεθος των υπερβολικά παραμετροποιημένων λύσεων που προκύπτουν σε χώρους υψηλών διαστάσεων. Στόχος αυτής της διατριβής, η οποία χρησιμοποιεί εργαλεία πολυμεταβλητής στατιστικής ανάλυσης δεδομένων, είναι να διερευνήσει, να αναλύσει, να συγκρίνει και να βελτιώσει υφιστάμενες τεχνικές, ενώ παράλληλα να εισάγει νέες για την αντιμετώπιση της πολυσυγγραμμικότητας και τη μείωση του χώρου (διάστασης) δεδομένων υψηλών διαστάσεων. Ειδικότερα, η παρούσα διδακτορική διατριβή σκιαγραφεί αρχικά το θεωρητικό πλαίσιο της μη επιβλεπόμενης τεχνικής της Ανάλυσης Κύριων Συνιστωσών καθώς και της αντίστοιχης επιβλεπόμενης δηλ. της μεθόδου Μερικών Ελάχιστων Τετράγωνων. Λόγω της ικανότητάς τους να επιτυγχάνουν μείωση διάστασης κατά την ανάλυση συνόλων δεδομένων υψηλών διαστάσεων, και οι δύο τεχνικές θεωρούνται βέλτιστες για δημιουργία νέων μεταβλητών. Η χρήση της πρώτης σε συνδυασμό με άλλες τεχνικές μείωσης διάστασης, καθώς και η τροποποίηση της δεύτερης, - ώστε να λειτουργεί ταυτόχρονα και ως τεχνική επιλογής μεταβλητών αλλά και ως τεχνική δημιουργίας μεταβλητών-, εφαρμόστηκαν και μελετήθηκαν διεξοδικά στους τομείς της οικονομετρίας, χρηματοοικονομικής και αναλογιστικής επιστήμης. Τέλος, στη διατριβή αυτή προτείνεται ένα εύρωστο και εύκολα ερμηνεύσιμο μη επιβλεπόμενο κριτήριο επιλογής μεταβλητών (Elastic Information Criterion), το οποίο είναι ικανό να εντοπίζει μοτίβα αλληλεξάρτησης μεταξύ των μεταβλητών ενός dataset. Το συγκεκριμένο κριτήριο δρα ταυτόχρονα (i) ως κριτήριο αξιολόγησης της ύπαρξης ή/και του βαθμού της πολυσυγγραμμικότητας και (ii) ως τεχνική επιλογής μεταβλητών.
The Isiac cults in Roman Greece
Authors: Μαϊκίδου-Πουτρίνο Δάφνη
Published: October 2022

Η έρευνα αυτή στοχεύει στη συλλογή και συστηματική παρουσίαση του υλικού πολιτισμού που σχετίζεται με τις Iσιακές θεότητες σε συγκεκριμένες περιοχές της Ρωμαϊκής Ελλάδας και την καταγραφή τους στα συγκείμενά τους, όπου αυτό είναι δυνατό. Επικεντρώνομαι στα υλικά τεκμήρια (αρχιτεκτονική, γλυπτική, επιγραφικά στοιχεία, νομίσματα, διάφορα άλλα αντικείμενα περιλαμβάνονται σε εξαιρετικές περιπτώσεις) που βρίσκονται όχι μόνο στα ιερά των Ισιακών θεοτήτων, αλλά και στους δημόσιους χώρους των πόλεων, τα νεκροταφεία και το οικιακό περιβάλλον. Καθώς ολόκληρη η Ρωμαϊκή Ελλάδα είναι ένας απέραντος χώρος, έχει επιλεγεί για να τεθούν κάποια γεωγραφικά όρια από τη Μακεδονία έως την Αττική. Ταυτόχρονα, τα χρονολογικά όρια εκτείνονται από το δεύτερο μισό του πρώτου αιώνα π.Χ. έως τον τέταρτο αιώνα μ.Χ. Όλα τα παραπάνω είναι συνυφασμένα καθώς οι άνθρωποι που ζούσαν στη Ρωμαϊκή Ελλάδα δόμησαν την Ισιακή θρησκευτική τους εμπειρία μέσα από τον υλικό πολιτισμό. Η Ρωμαϊκή Ελλάδα ήταν ένα πολυπολιτισμικό περιβάλλον με ελληνικές, ρωμαϊκές, και σε αυτή την περίπτωση ξεχωρίζω και τις αιγυπτιακές συνιστώσες. Ο Ελλαδικός πολιτιστικός χώρος ήταν λοιπόν μέρος ενός πυκνού δικτύου επικοινωνιών. Οι Ισιακές θεότητες μελετώνται ως μέρος αυτού του δικτύου. Η λατρεία τους είχε μια κοινή γενέτειρα: την Αίγυπτο. Οι διαφοροποιήσεις που παρατηρούνται στο ελληνικό πολιτιστικό τοπίο προέρχονται από πολλούς παράγοντες: ποιος και πότε εισήγαγε πτυχές της λατρείας, ποιες ήταν οι προϋπάρχουσες θεότητες σε κάθε τοποθεσία και ποια ήταν η σχέση που είχε κάθε πόλη με τους Ρωμαίους. Κατά συνέπεια, η συμβολή αυτής της έρευνας στη μελέτη των Ισιακών λατρειών στοχεύει να δράσει σε περισσότερες από μία διαστάσεις. Προσφέρω μια συστηματική συλλογή των δεδομένων σε κάθε ξεχωριστή περιοχή και τοποθεσία σε μια τεράστια έκταση που δεν έχει μελετηθεί σε βάθος. Εκτός από την κάλυψη αυτού του κενού στην έρευνα, χρησιμοποιώ θεωρητικές προσεγγίσεις για να συνεισφέρω σε μια ολιστική θεώρηση των Ισιακών λατρειών σε αυτές τις περιοχές και να προσεγγίσω τους δρώντες ανθρώπους πίσω από τα αντικείμενα. Ως εκ τούτου, τα ερευνητικά ερωτήματα συγκεντρώνονται γύρω από τρία διαφορετικά θέματα: το πρώτο δίνει έμφαση στον υλικό πολιτισμό, το δεύτερο επικεντρώνεται στον τρόπο δομής της επικοινωνίας μεταξύ των ανθρώπων και του θείου σε κάθε τοποθεσία και το τρίτο επισημαίνει τις συνδέσεις του υλικού πολιτισμού και των λατρευτικών πρακτικών με ανάλογα ιερά σε άλλες τοποθεσίες της Ελλάδας και την αναγνώριση των κοινών ή και παγκόσμιων χαρακτηριστικών της έκφρασης της λατρείας που σχετίζονται με αυτή την γεωγραφική περιοχή. Επιπλέον, η λατρεία της ηπειρωτικής Ελλάδας συχνά συγκρίνεται και παραλληλίζεται τόσο με Ανατολικές όσο και με Δυτικές περιοχές της Ρωμαϊκής Αυτοκρατορίας.
Familial hypercholesterolemia. Perspectives on FH registry systems
Authors: Pavlatou Niki , Kadda Olga , Marvaki Christina , Kolovou Genovefa
Published: October 2022

Familial Hypercholesterolemia (FH) is a genetic cause of premature Cardiovascular Disease (CVD) which is the leading cause of morbidity and mortality worldwide. In Greece, it is estimated that 90% of patients remain undiagnosed. Patients with FH are at high risk for cardiovascular events, peripheral arterial disease, stroke and death at a young age. Therefore, early detection of these is important for the implementation of appropriate preventive measures. Patient medical records are a powerful tool for recording and monitoring the disease and promoting clinical practices, thus helping to improve outcomes and reduce the cost of healthcare. Simultaneously with the registers, patient-centered management, multidisciplinary teamwork, involvement of primary care physicians, patient networks and support teams are required. Of most importance is the Greek online register system of people with familial hypercholesterolemia, by the Hellenic Atherosclerosis Society in collaboration with major hospital centers and the Hellenic College of Atherosclerosis Treatment registration system in the community. The purpose is to find people who are suffering from FH, to diagnose, to educate them and to put them under treatment and follow-up. In conclusion, effective care of patients with dyslipidemia requires: a) detailed evaluation of medical history, b) clinical and laboratory tests, and c) patient education programs regarding lifestyle changes and disease management. The above strategies of care will help reduce time and cost of medical treatment, obtain better clinical outcome and improve patients’ quality of life.
Management of acute pancreatitis in the Emergency Department
Authors: Tsiampas Ioannis
Published: October 2022

Background: Heterogeneity in clinical manifestations and outcome of pancreatitis constitutes an obstacle for the creation of a common treatment algorithm by the scientific community.

Aim: The aim of the present study was to systematically review the management of cases of acute pancreatitis in Emergency Department (ED) and her correlation with outcome.

Methods: Search the database Pubmed and were included observational studies and randomized trials in adults in English.

Results: The search yielded 13 studies. Of these, 3 concerned the diagnostic approach of the disease in ED and concluded that lipase is the most reliable test in diagnosis, while computed tomography of the abdomen is not recommended as a routine examination. 5 out of 13 studies analyzed the usefulness of disease severity classification systems, with the BISAP and HASP score appearing as reliable as the APACHE II and RANSON score, but having an advantage in rapid patient evaluation. The last 5, studied the need for immediate therapeutic / invasive method, with the time of surgery from the arrival at the ED being decisive as it affects the outcome of the disease. It is generally seen that the early invasive method is gaining ground in the treatment of the disease.

Conclusion: The main goal is to predict the most severe forms of the disease in order to receive the right (invasive or not) treatment to improve survival and quality of life.
Tax audit
Authors: Savin Aleksandr , Mel'nik Margarita , Dvoreckaya Vera , Glazkova Galina , Suhareva Irina , Rogulenko Tat'yana
Published: October 2022

The textbook discusses aspects of improving the practice of tax and customs control. The theoretical aspects of building a tax audit system, the specifics of the practices of auditing individual taxes and customs value are highlighted. A brief description of the system of taxes and fees of Russia is given, the prospects for its further improvement are considered.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of higher educational institutions studying in the economic areas of training "Audit and control", "Taxes and taxation", "Tax audit".
Law enforcement agencies
Authors: Mironov Anatoliy , Ryabov Sergey
Published: October 2022

The textbook has been prepared on the basis of studying the theoretical and practical provisions of the organization and functioning of state-governmental law enforcement structures directly related to issues of security and law and order in the territory of the Russian Federation. Information is provided on the main activities, goals, objectives, structure, principles of organization and powers of law enforcement agencies, taking into account changes in legislation in the process of reforming the system of public authorities and management.
Meets the requirements of the federal state educational standards of secondary vocational education of the latest generation.
For students of secondary specialized and higher educational institutions studying in the specialty and direction of training "Jurisprudence", as well as for teachers and practitioners.
Modern electrical substations
Authors: Popadyuk Tat'yana , Smirnova Irina , Linder Nataliya , Trachuk Arkadiy , Nalbandyan Gayk , Karikova Anastasiya , Pogosyan Aleksandra , Litvin Irina , Paskalova Galina , Solncev Il'ya , Hovalova Tat'yana , Hachaturyan Mihail , Sharkova Antonina
Published: October 2022

The textbook provides general information about the operating modes of electrical systems and substations, methods for calculating short-circuit currents and selecting electrical equipment for substations and power grids, classification of substations is given, designs of manual control transformers, high-voltage and low-voltage substations are considered, issues of their relay protection, requirements of electrical installation rules and technical operation rules for the device and operation of substations.
It is intended for students of the training direction 13.03.02 "Electric power and electrical engineering", and can also be useful for students of secondary vocational education, masters and electrical engineers who improve their technical level on the job.
Circular economy: ensuring sustainable development and competitiveness of the region
Authors: Antonova Irina , Kormishkina Lyudmila , Salimova Tat'yana , Gerhard Sheve , Stefan Hyuzig , Gumerova Gyuzel' , Butneva Aleksandra , Shaymieva El'mira , Animica Evgeniy , Timiryasova Asiya , Burmistrov Vyacheslav , Abzalilova Leysan , Smirnov Vitaliy
Published: October 2022

The monograph summarizes the accumulated domestic and foreign experience in the field of closed-cycle economics, outlines modern approaches to the formation of sustainable development of regions, makes proposals for improving regional management systems based on the introduction of innovative business models of this type, and also considers issues of standardization and regulatory support of the closed-cycle economy.
It is intended for postgraduates, undergraduates, bachelors studying in the areas of training and specialties "Quality Management", "Standardization, metrology", "Innovation management" and "Technosphere safety". It may be of interest to managers, specialists and a wide range of people interested in improving the processes and results of their activities based on the principles of sustainable development.
Tax system: theoretical and methodological aspect. Tax product
Authors: Privalov Nikolay , Privalova Svetlana , Tarasevich Aleksey , Romanovskiy Mihail
Published: October 2022

The monograph examines the theoretical issues of taxes and the tax system: their essence, functions, classifications. The authors propose original concepts of the methodology of socio-economic systems, a political economic version of taxes as a "product" involved in the exchange processes of the state and other sectors of the economy.
It is addressed to all those interested in economics, researchers, teachers, students and postgraduates of economic specialties.
The multi-currency standard and the global financial market
Authors: Alekseev Petr , Antropov Vladislav , Barabanov Valeriy , Bich Mihail , Zharikov Mihail , Krylova Lyubov' , Kuznecov Aleksey , Morozov Sergey , Navoy Anton , Saharov Dmitriy , Golovnin Mihail , Perskaya Viktoriya
Published: October 2022

The monograph was prepared by a team of authors of the Financial University under the Government of the Russian Federation based on the results of research carried out at the expense of budgetary funds under the state assignment of the Financial University.
The directions, forms and prospects of creating a multi-currency standard in the process of transformation of the world monetary and financial system are investigated. An integral model for assessing the sectoral development of the global financial market has been developed. The possibilities of adapting the Russian financial market to innovative digital technologies in the context of the formation of a new monetary and financial paradigm are considered.
It is of interest to researchers, teachers, postgraduates, students specializing in the study of international economic relations, as well as to a wide range of readers interested in the problems of the development of the world monetary and financial system and the global financial market.
The social wealth of the innovation system
Authors: Sazhina Muza , Kashirova Anna , Makarov Stanislav , Osiop Egor
Published: October 2022

The monograph reveals the key socio-economic problems of the innovation economy: its content as a knowledge economy and its role in evolutionary development; human capital (living intelligence) as the main resource of the innovation economy. Much attention is paid to the institutional support of innovation through a system of institutions and mutually beneficial contracts. The mixed mechanism of implementation of innovative activity as a synthesis of spontaneous market self-regulation and conscious public administration is shown. The result of the "social control" of society and the state is the coordination of the actions of economic entities and the ordering of economic processes.
The most important institution of human society is the family as a strong power in the state. And the person himself with his knowledge, culture, ethics and morality is the main value of society. The main purpose of the family is to reproduce life and provide a person with everything necessary. The state as an institution manages a person's education and health, helps to change his lifestyle, strengthening humanity, ethics, morality and culture of life.
The modern global economy remains a sphere of domination of market egoism. It is the market that performs the function of morality as a person and society as a whole. In the global economy, a person is not a representative of the people, but a representative of the system, a standard way of life. And he should live in communication based on respect for each other.
It is concluded that today the main wealth of society is not material, but social wealth: the person himself with his knowledge, culture, ethics and morality is a living intellect; a family with the reproduction of life; immaterial knowledge that covers all types of work that cannot be calculated and paid, where the motive is the joy of free cooperation, free giving and community. In this "invisible economy" people mutually teach each other humanity and create a culture of joint thinking and living together. The State and society must preserve and increase the social wealth of human society.
For students and postgraduates of economic and managerial specialties, as well as for anyone interested in this problem.
The continuous formation of the stochastic culture of schoolchildren in the context of the digital transformation of general education
Authors: Polyakova Anna , Sergeeva Tat'yana , Kitaeva Irina
Published: October 2022

The material presented in the monograph shows the possibilities of continuous teaching of mathematics at school, namely, the significant potential of modern information and communication technologies, with the help of which it is possible to form elements of stochastic culture among students. Continuity in learning is considered from two positions: procedural and educational-cognitive. In addition, a distinctive feature of the book is the presentation of the digital transformation of general education as a way to overcome the "new digital divide". Methodological features of promising digital technologies (within the framework of teaching students the elements of the probabilistic and statistical line) that contribute to overcoming the "new digital divide": artificial intelligence, the Internet of Things, additive manufacturing, machine learning, blockchain, virtual and augmented reality are described.
The solution of the main questions of probability theory and statistics in the 9th grade mathematics course is proposed to be carried out using a distance learning course built in the Moodle distance learning system. The content, structure and methodological features of the implementation of the stochastics course for students of grades 10-11 of a secondary school are based on the use of such tools in the educational process as an online calculator for plotting functions, the Wolfram Alpha service, Google Docs and Google Tables services, the Yaklass remote training, the Banktest website.", interactive module "Galton Board", educational website "Mathematics at school".
It will be interesting for students, undergraduates, postgraduates, mathematics teachers, as well as specialists improving their qualifications in the field of pedagogical education.
Innovations and modern business models
Authors: Popadyuk Tat'yana , Smirnova Irina , Linder Nataliya , Trachuk Arkadiy , Nalbandyan Gayk , Karikova Anastasiya , Pogosyan Aleksandra , Litvin Irina , Paskalova Galina , Solncev Il'ya , Hovalova Tat'yana , Hachaturyan Mihail , Sharkova Antonina
Published: October 2022

The textbook gives a general idea of innovations and modern business models. The concept and role of innovations in the modern world are considered, including the theory of innovations and their classification, the structure and dynamics of the innovation process; the concept of a business model, types of business models, as well as the development of business modeling in the digital economy are highlighted.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of higher educational institutions studying in the direction of training "Management".
Numerical methods in assessing and predicting the quality of heat-protective clothing
Authors: Abramov Anton , Rodicheva Margarita , Shustov Yuriy , Kiselev Mihail , Azanova Al'bina
Published: October 2022

The monograph discusses the issues of thermal calculations of packages of textile materials and clothing sets. A generalized calculation method is presented, within which computational problems can be solved, as well as the data necessary for its implementation.
The study of the presented material will allow specialists in the field of clothing design, students studying in the areas of training 27.03.01 (27.04.01) "Standardization and metrology", 29.03.01 (29.04.01) "Technologies and design of textile products", to obtain the necessary theoretical foundation for solving numerical modeling problems in assessing the quality of heat-protective clothing.
Circular model of economic growth: experience, opportunities and barriers
Authors: Ratner Svetlana , Nazarova Liliya , Kirdasinova Kasiya , Karapetyan Anna
Published: October 2022

The concept of a circular (or circular/closed cycle) economy is quite new for the Russian scientific literature on economics and management. Having originated initially in countries experiencing serious resource constraints and (or) acute environmental problems, a few months ago it seemed to be a curious idea for Russia, allowing in the long term to achieve simultaneous preservation and even an increase in economic growth rates without the concomitant increase in the expenditure of natural resources and the inevitably associated increase in the burden on the environment. However, the dramatically changed economic situation due to unprecedented sanctions pressure, the freezing of the country's financial resources and the destruction of a huge number of production chains forces us to take a fresh look at the concept of a circular economy and shift the focus of research on its possible practical applications from environmental aspects to such topical economic aspects as creating new jobs, products and services, preserving the quality of life of the population while decrease in purchasing power, etc. A feature of the monograph is the focus on new opportunities for economic growth that the circular economy provides, even in conditions of severe resource (including financial) constraints.
It is intended for students, masters, postgraduates, researchers, as well as practitioners from the field of management with modern circular business models and methods of organizing production and consumption processes according to the circular type.
Fundamentals of dissertation management
Authors: Reznik Semen , Petrov Petr , Treschevskiy Yu.
Published: October 2022

The textbook discusses the management system of the processes of training and certification of scientific personnel in Russia.
Considerable attention is paid to the preparation, organization and conduct of dissertation research, preparation for the defense of a dissertation, organization of personal activities of a graduate student.
For students of higher educational institutions who associate their future with master's and postgraduate studies; for graduate students of higher educational institutions, as well as for anyone interested in the problems of dissertation management.
Dimensional effects in phase transitions and physical properties of ferroics
Authors: Nechaev Vladimir , Shuba Andrey , Gridnev Stanislav , Topolov Vitaliy
Published: October 2022

The monograph presents mathematical methods and a set of mathematical models describing, within the framework of phenomenological theory, phase transitions in 0D-. 1D-, 2D-, 3D-dimensional ferroelectrics, ferroelastics, ferromagnets and their static and dynamic physical properties near the phase transition point. The influence of the parameters characterizing the ferroic sample and its interaction with the environment on the features of the phase transition, phase transition temperature shift, heat capacity, generalized susceptibilities is analyzed. Mathematical models of multilayer thin-film structures and composite materials, where one of the components is a ferroic nanoparticle, are considered. In general, modern ideas about dimensional effects in ferroelectrics, ferroelastics, ferromagnets and mechanisms of purposeful influence on their properties are sufficiently fully covered.
It is intended for researchers, students and postgraduates of physical specialties of universities interested in fundamental problems of formation of physical properties of low-dimensional materials. Research engineers, developers of new materials can use the presented material as a scientific and methodological basis to support the development of optimal solutions for their creation.
Problems in the management of a geriatric patient with colorectal cancer based on ICNP® - a case report
Authors: Gierosz Daria , Mess Eleonora
Published: October 2022

Colorectal cancer is the third most common malignancy among the population. The average incidence is over 65 years of age. The majority of cases are not hereditary and sporadic infections predominate. The aim of this study was to determine the most important nursing problems of a patient with colorectal cancer , as well as to recognize his bio-psycho-social situation. Using interview technique, physical examination, observation and research tools such as standardized scales and indicators. This allowed to prepare and implement a holistic nursing proces. The most important nursing problems in the analyzed case were: hypoxia of the patient, limitation of independence as a result of weakness of the organism, pain in the bony button, dehydration, occurrence of skin changes in the stoma area, anxiety and lack of acceptance of the disease state. There were also knowledge deficits regarding dietary recommendations, as well as the effects of nicotine on the human body.
ETHER - a partially forgotten anesthetic
Authors: Pożarowska Kinga , Rosińska Agata , Orczykowski Maciej , Tyszkiewicz Marcin , Choina Magdalena
Published: October 2022

INTRODUCTION: Ether is the common name for diethylether (CH3-CH2-O-CH2-CH3). It is a colorless, volatile and highly flammable liquid with a characteristic pungent odor. It was widely used as an anesthetic in the past and is now a component of solvents. 

PURPOSE OF THE WORK: The purpose of this paper is to introduce ether as a potentially forgotten substance in the world of Western medicine. Its history, current use, potential for abuse for narcotic purposes, addiction, and the benefits of anesthesia with this agent in impoverished countries.

DESCRIPTION OF THE STATE OF KNOWLEDGE: Ether was first synthesized in 1540 by Valerius Cordus. Ether is characterized by rapid absorption, rapid distribution in the central nervous system and rapid, short-lasting effects. Ether has high solubility in blood/gas, which slows both induction and recovery of anesthesia. In developing countries, it is suggested that ether be used as an intraoperative analgesia. But it should be remembered, despite the new psychoactive substances, other inexpensive and readily available intoxicants can be found, among them ether. It has been noted in numerous publications that abuse of ether is associated with abuse of other drugs and/or alcohol dependence.

SUMMARY: It is important to remember that ether compounds are widespread. People struggling with the urge to abuse substances can get these substances easily and cheaply. On the other hand, ether anesthesia is a great solution for developing countries. There are situations there that due to lack of funds, some operations are carried out without anesthesia. Ether is cheap, and administering anesthesia with it is quite simple, and could give wonderful relief to these patients.
Children in care
Authors: Kemmis John
Published: October 2022

The final shape of the Children and Families Bill, introduction of the 26-week care proceedings target, expansion of free childcare and school meals, and doing more with less in the face of further public sector funding cuts – these are just some of the issues professionals and services will grapple with over the coming year. With the election just around the corner, CYP Now's 2014 Report invites sector leaders to pinpoint the challenges that lie ahead
Growing your own talent
Authors: Hayes Derren
Published: October 2022

Derren Hayes meets Denise Hatton, chief executive of YMCA England
Vision of a grand coalition
Authors: Puffett Neil
Published: October 2022

Neil Puffett meets Javed Khan, chief executive at Barnardo's
Working with dyslexic children
Authors: Anderson Stephanie
Published: October 2022

Children who are dyslexic need not be held back by the condition, but early identification is key, says Stephanie Anderson
Child protection competition backed by Narey
Authors: Narey Martin
Published: October 2022

Government adviser Martin Narey defends the role of the private sector in delivering public services and says it could improve social care for children
First aid for babies and children
Authors: Stoddart Paul
Published: October 2022

Everyone working in a childcare setting should be able to respond effectively when faced with an incident requiring first aid knowledge
Better training and more government investment tops childcare wish list
Authors: McCardle Laura
Published: October 2022

With childcare set to be a key battleground in next year's general election, CYP Now gets the views of early years and children's organisations on what their main policy priorities are for a future government
Jobs and Training Trends
Authors: Goddard Charlotte
Published: October 2022

Youth work courses are continuing to adapt to meet changing employment conditions in the sector. Charlotte Goddard examines how institutions are preparing students for employment opportunities
Seeking a New Life
Authors: Hunt Louise
Published: October 2022

Each year, hundreds of young asylum seekers enter the UK in search of help and protection. Louise Hunt went to visit the Kent Refugee Action Network, one of the projects attempting to support these vulnerable children and young people to make a new life in a strange land
Working with co-parents
Authors: Rhodes Honor
Published: October 2022

Co-parents – individuals with dual parenting roles – are a growing group that early years practitioners need to be mindful of
A service in transition
Authors: Hayes Derren
Published: October 2022

Derren Hayes talks to Dalton Leong, chief executive of the Children's Trust
Helping children with Crohn's
Authors: Barker David
Published: October 2022

Crohn's disease is a growing problem that can cause great discomfort and anxiety to children and young people who suffer with the condition
Fears raised over premium use
Authors: McCardle Laura
Published: October 2022

Allowing providers to choose how they use the early years pupil premium could see it offset losses elsewhere
The It Crowd
Authors: Fursland Eileen
Published: October 2022

Dangers posed by cyberspace and prized gadgets are a concern for those working with looked-after children. Eileen Fursland explores the more positive contribution technology makes to young lives
Call for action plan on FGM
Authors: Gosby Catrin
Published: October 2022

The home affairs committee has published a report calling for a national action plan on female genital mutilation. Catrin Gosby, researcher at Coram Children's Legal Centre, examines the report's proposals
Getting Away from it All
Authors: Lepper Joe
Published: October 2022

Residential trips have formed a core part of youth provision over many years. Joe Lepper explores how these sometimes life-changing experiences have evolved to meet the needs of young people today
Establish a mentoring programme
Authors: Smart Junior
Published: October 2022

Mentors can play an important supportive part in the lives of children and young people who lack positive role models to look up to
Urgent action needed for Neets
Authors: Fitzjohn Laura
Published: October 2022

Councils need more powers to drive improvement in 16-19 education and training, says Ofsted's Lorna Fitzjohn
Panel of experts set out to get adoption sector's ‘house in order’
Authors: Puffett Neil
Published: October 2022

Members of the government's new Adoption Leadership Board explain how they will help ensure adoption reforms change local services on the ground and improve the system for children and adoptive parents
Respond to domestic violence
Authors: Neate Polly
Published: October 2022

Knowing how to respond to children experiencing domestic violence can make all the difference in ensuring they get the right support
Councils make their case for more self-rule
Authors: McCardle Laura
Published: October 2022

Following the Scottish independence referendum, local government groups call for English councils to gain more control of children's budgets
Doncaster's deliverer
Authors: Puffett Neil
Published: October 2022

Neil Puffett meets Paul Moffat, chief executive, Doncaster Children's Services Trust
Sector divided over merits of mandatory abuse reporting
Authors: Puffett Neil
Published: October 2022

Recent high-profile child abuse cases have led to a growing support for mandatory reporting of abuse allegations. But some experts believe such moves could have unintended consequences that could harm the child protection system
Campaigner for expansion
Authors: Puffett Neil
Published: October 2022

Neil Puffett speaks to Andy Elvin, chief executive of Tact
Children's rights and the internet
Authors: Anderson Kirsten
Published: October 2022

Kirsten Anderson, research and policy manager at Coram Children's Legal Centre, examines recent guidance on balancing children's right to access information with the need to protect them from harm
Councils prepare for integrated education and health reviews
Authors: McCardle Laura
Published: October 2022

Bringing together the health and early development reviews for two-year-olds could smooth the assessment process for parents, but experts fear a lack of resources and services will result in little impact on children's outcomes
Protection system ‘fails adolescents’
Authors: Puffett Neil
Published: October 2022

Experts say councils must ensure local child protection procedures meet the needs of older children
Local authorities devise plans to beat child sexual exploitation
Authors: Puffett Neil , McCardle Laura
Published: October 2022

Despite recent reports criticising child protection agencies for failings over their handling of sexual exploitation, some local authorities are taking the lead on awareness-raising to tackle the problem and identify those at risk
Minister sets bar for extending support to children in care homes
Authors: Hayes Derren
Published: October 2022

A grassroots movement may have succeeded in getting the government to look again at supporting children in residential care until they are 21, but many hurdles need to be overcome before it will get ministerial backing
Tackling Truancy sanctions and support
Authors: Lepper Joe
Published: October 2022

A major government crackdown on truancy includes a ban on term-time holiday and steeper fines for parents. Joe Lepper explores the success of different approaches to ensuring children attend school
Tackling obesity in children
Authors: Fry Tam
Published: October 2022

Obesity can have far-reaching consequences on children's lives, so professionals must take action when they spot the warning signs
Local projects tackle youth gangs
Authors: Puffett Neil
Published: October 2022

A report on the Ending Gang and Youth Violence programme highlights good practice to learn from
Tackling mental illness
Authors: Daniel Matthew
Published: October 2022

Mental health problems among children and young people are on the increase and the support available is getting harder to access
Cutting reoffending tops YOT list
Authors: Puffett Neil
Published: October 2022

Developing a good understanding of young offenders' circumstances is key to preventing reoffending
High aspirations for all
Authors: McCardle Laura
Published: October 2022

Laura McCardle meets Chris Wright, chief executive of Catch22
The A to Z of Evaluation
Authors: Lepper Joe
Published: October 2022

Good evaluation is critical for both children's services providers and commissioners since work that can demonstrate results is more likely to gain funding. Joe Lepper covers all the essentials in this A to Z guide
Access to sexual health services
Authors: Yarrow Elizabeth
Published: October 2022

Elizabeth Yarrow, senior researcher at Coram Children's Legal Centre, summarises recent research that explores the impact of the law on young people's access to sexual and reproductive health services
Championing Young People's Health
Authors: Hunt Louise
Published: October 2022

GPs and voluntary youth organisations are joining forces to improve primary care services for young people. Louise Hunt visits one of the trial projects in Liverpool and looks at the lessons learned so far
Working to prevent knife crime
Authors: Ribeiro Monique
Published: October 2022

Addressing the reasons why a young person is carrying a knife can be central to diverting them from risky behaviour
A provocative president
Authors: Puffett Neil
Published: October 2022

Neil Puffett meets Alan Wood, the new president of the ADCS
Your guide to the Children and Families Act
Authors: Hayes Derren , McCardle Laura , Puffett Neil
Published: October 2022

What the act means for everyday practice across the children's workforce
Prepare young people for interviews
Authors: Reed Kirsty
Published: October 2022

In a tough jobs market, young people need support to improve their chances of getting on the first rung of the employment ladder
Careers reforms fail to convince
Authors: McCardle Laura
Published: October 2022

Experts say new guidance on school careers advice are a “step in the right direction” rather than a solution
Defender of a just cause
Authors: Puffett Neil
Published: October 2022

Neil Puffett meets Lord McNally, chair of the Youth Justice Board
Is there any legal aid safety net?
Authors: Hurrell Anita
Published: October 2022

The safeguard for those needing legal assistance in areas of law not generally covered by legal aid has not been working, explains Anita Hurrell, legal and policy officer at Coram Children's Legal Centre
Promoting sexual identity tolerance
Authors: Marston Kate , Charlesworth Jonathan
Published: October 2022

Children's professionals have a duty to celebrate diversity and educate children and young people to respect same-sex relationships
Councils fear impact of more cuts
Authors: Hayes Derren
Published: October 2022

Local authorities warn of dire consequences if the government pushes ahead with spending reductions
Councils struggle to meet rise in demand for child protection
Authors: Puffett Neil
Published: October 2022

Freedom of Information Act data shows there has been a rise over the past year in the number of children in care and on child protection plans, with children's services leaders warning of major consequences for how councils work
Councils and charities absorb the impact of Whitehall spending cuts
Authors: Hayes Derren
Published: October 2022

Recent cuts to government department budgets look set to be the start of a new round of austerity in public sector spending. Three experts outline the impact these cuts will have and offer ideas on how the effect can be minimised