bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic Algorithms for Real-time Routing Traceability: Planning and Optimization
Authors: Smaili Yamina , MOUSS Nadia Kinza , AKSA Karima
Published: September 2022

The customer is king! It is a business/marketing concept. The notion of customer-king refers to that of customer satisfaction. The latter makes it possible to retain the customer and, therefore, to ensure regular cash flow on his part. In the COVID-19 pandemic, daily life has changed and revealed the utmost importance of traceability and standardization to effectively monitor people, assets in the healthcare industry, information, and product distribution.Traceability is among the logistics industry concerns. It plays a vital role in the supply chain to guarantee high service quality and thus maintain the luxurious brand image of the company with reduced distribution costs and increased customer satisfaction. Traceability has seen significant use in recent years thanks to the emergence of technologies such as the Internet of Things (IoT), Intelligent Sensors, and Radio Frequency Identification.... These technologies, involved in the fourth industrial revolution, are viewed as powerful and rapidly growing innovative technologies used to meet the customer pain points, offer better visibility, and add more transparency and reliability to product information throughout their life cycles. This paper presents a contribution to the real-time traceability field through the design of algorithms for dynamic vehicle routing problems (DVRP). It provides a methodology for real-time traceability of vehicles and a Plan Consumers Visit PCV intending to achieve the best solution for the re-optimization on-the-fly or online optimization cost delivery. Thus, it chose the most critical problems in logistics that of several vehicles which start from a common distribution center following a well-defined route without exceeding their charging capacity for serving different customers. Through the IoT technology, real-time information about vehicles and customers' requests can be collected and transmitted to the distribution center for analysis and making better decisions. Even updating the delivery planning is available in real-time in case of receiving new sudden requests during the delivery trip.
Pulmonary function during interscalene block vs supraclavicular block: a single-centre, double-blind, randomized, controlled trial
Authors: WANG Jiajia , HOU Xinwei , ZHANG Xiao , WANG Xueting , QIN Weiwei , LI Qiujie , MA Fuguo , SUN Lixin
Published: September 2022

BACKGROUND: The supraclavicular plexus block (SPB) and interscalene plexus block (IPB) have the potential to pulmonary function, the duration of the potential remains uncertain. So, we compared the effect of SPB and IPB on pulmonary function, especially the duration time.
METHODSː Ninety-eight patients were randomly allocated to group I and group S. The IPB and the SPB procedures were performed with ultrasound guidance before anesthesia induction. An investigator recorded the diaphragm mobility and respiratory function test indicators before the block (T0) and at 30 min (T30 min), 4 h (T4), 8 h (T8), and 12 h (T12) after the block. The diaphragmatic paralysis rate was calculated for above timepoint. The VAS, the recovery time for the sensory and motor block, and adverse reactions within 24 hours of administering the block were also recorded.
RESULTSː The recovery times of diaphragm mobility in group I were longer than those in group S. Compared with group I, group S had a significantly lower diaphragmatic paralysis rate during eupnea breathing at T30 min, and T8 after the block. Similarly, group S had a significantly lower diaphragmatic paralysis rate at deep breathing at T30 min, T8 and T12 after the block. The recovery times of FEV1 and FVC in group I were longer than those in group S. The other results were not statistically significant.
CONCLUSIONSː Ultrasound-guided IPB resulted in a longer periods with a suppressive effect on pulmonary function than SPB.
Clinical Trials Registration：17/12/2019, ChiCTR1900028286
Dietary garlic supplementation positively affects the immunological system of juvenile cobia Rachycentron canadum reared in net pens during winter
Authors: Nóbrega Victor Santos Lira da , Rombenso Artur Nishioka , Pedrosa Virgínia Fonseca , Romano Luis Alberto , Sampaio Luís André , Rodrigues Ricardo Vieira
Published: September 2022

The objective of the present study was to evaluate the effect of garlic (Allium sativum) in the diet of juvenile cobia Rachycentron canadum reared in near shore net pens during winter in the coast of Rio de Janeiro (Brazil). Fish (172 ± 19 g and 31.1 ± 1.4 cm) were stocked in 6 cages (n=40 per cage). Two moist diets were prepared, a control diet without garlic and an experimental diet formulated to include 1% dry garlic. Fish were reared on these diets for 68 days, and at the end of the trial. Growth and survival were not affected by garlic inclusion (P>0.05). On the other side, significant differences (P<0.05) were observed for hematological and immunological parameters. The number of monocytes, thrombocytes, and the neutrophil:lymphocyte ratio were higher (P<0.05) in the control compared to the garlic supplemented diet. Whereas lymphocytes counting and phenotypic expression of lymphocyte receptors CD3 and CD4 were higher in diets containing garlic. Supplementation with 1% of garlic in the diet is recommended to boost the immune system and minimize stress of cobia juveniles farmed in near shore net pens during the winter.
Chemoselective carbene insertion into the N−H bonds of NH3·H2O
Authors: Liu Zhaohong , Yang Yong , Song Qingmin , Li Linxuan , Zanoni Giuseppe , Liu Shaopeng , Xiang Meng , Anderson Edward , Bi Xihe
Published: September 2022

The conversion of inexpensive aqueous ammonia (NH3·H2O) into value-added primary amines by N − H insertion persists as a longstanding challenge in chemistry because of the tendency of Lewis basic ammonia (NH3) to bind and inhibit metal catalysts. Herein, we report a chemoselective carbene N − H insertion of NH3·H2O using a TpBr3Ag-catalyzed two-phase system. Weak coordination by a homoscorpionate ligand enables silver compatible with NH3and H2O and ensures the generation of electrophilic silver carbene. Water promotes subsequent [1, 2]-proton shift to generate N − H insertion mono-substituted products with high chemoselectivity. The end result of the reaction is the coupling of an inorganic nitrogen source with either diazo compounds orN-triftosylhydrazones to produce useful primary amines. Further investigations elucidate the reaction mechanism and the origin of chemoselectivity.
Virtual Surgical Training – first experiences of an online suture course
Authors: Stutz Janine , Pizanis Antonius , Wolf Milan Anton , Fischer Gerrit , Langer Frank , Scherber Philipp-Robert , Orth Marcel , Pohlemann Tim , Fritz Tobias
Published: September 2022

Background: Due to the SARS-CoV-2-pandemic and associated contact restrictions, established lectures and seminars could not take place in presence as usual in 2020. In the first online-based summer semester 2020, the lack of practical content was noted by medical students of our institution. To provide basic practical surgical skills, a hybrid course was developped. A home-based suture kit was given to all medical students and a web-based live suturing skills course was performed.
Methods: A total of 104 medical students participated in the online suturing skills course in 2 remote video sessions (Microsoft Teams®, Redmond, USA) of 90 minutes each. The students were taught theoretical and practical contents of surgical suturing skills and knotting techniques by a surgical resident in small groups of 12 participants. For this purpose, each student was previously given a personal basic surgical instruments training kit. Single stitches, mattress suture, intracutaneous suture and surgical hand knots were trained. In addition, an online questionnaire (Survey Monkey), which was processed before and after the course was performed. Furthermore, the evaluation of surgical skills, the course execution and the intended future medical discipline were investigated via the survey.
Results and conclusion: All students rated increased skills of their suture and knot skills after the course. 80% of them had no experience with basic surgical skills prior to the course. Before the course, 33% of the participants wanted to become a surgeon compared to 41% after the course. The skills to perform single stitches and a surgical hand knot increased by 70% after the course. Also, theoretical knowledge increased after the course. Furthermore, the students were satisfied with the concept and the implementation of the course.
In summary, by means of this online suturing skills course without any personal contact between instructor and student the competence of medical students in basic surgical skills could be improved and students were motivated to pursue a career in surgery. This hybrid format appears as a viable alternative, therefore it should be integrated into the curriculum in addition to courses in presence.
Intracranial Neurofeedback Modulating Neural Activity in the Mesial Temporal Lobe During Memory Encoding: A Pilot Study
Authors: Koizumi Koji , Kunii Naoto , Ueda Kazutaka , Takabatake Kazuhiko , Nagata Keisuke , Fujitani Shigeta , Shimada Seijiro , Nakao Masayuki
Published: September 2022

Removal of the mesial temporal lobe (MTL) is an established surgical procedure that leads to seizure freedom in patients with intractable MTL epilepsy; however, it carries the potential risk of memory damage. Neurofeedback (NF), which regulates brain function by converting brain activity into perceptible information and providing feedback, has attracted considerable attention in recent years for its potential as a novel complementary treatment for many neurological disorders. However, no research has attempted to artificially reorganize memory functions by applying NF before resective surgery to preserve memory functions. Thus, this study aimed (1) to construct a memory NF system that used intracranial electrodes to feedback neural activity on the language-dominant side of the MTL during memory encoding and (2) to verify whether neural activity and memory function in the MTL change with NF training. Two intractable epilepsy patients with implanted intracranial electrodes underwent at least five sessions of memory NF training to increase the theta power in the MTL. There was an increase in theta power and a decrease in fast beta and gamma powers in one of the patients in the late stage of memory NF sessions. NF signals were not correlated with memory function. Despite its limitations as a pilot study, to our best knowledge, this study is the first to report that intracranial NF may modulate neural activity in the MTL, which is involved in memory encoding. The findings provide important insights into the future development of NF systems for the artificial reorganization of memory functions.
Central hepatectomy versus major hepatectomy for patients with centrally located hepatocellular carcinoma; a systematic review and meta-analysis
Authors: Gadallah Edward Atef , Elkomos Beshoy Effat , Khalil Ahmed , fawzy Fawzy Salah , Abdelaal Amr
Published: September 2022

Background and Aim: For those with a centrally located HCC, the two types of liver sectionectomy that can be performed are extended hepatectomy (EH) and central hepatectomy (CH). The aim of this meta-analysis was to compare the short- and long-term outcomes between patients treated with CH and patients treated with EH for those with centrally located HCC.
Method: We searched PubMed, Scopus, Web of Science, Cochrane library for eligible studies from inception to 1 April 2022 and a systematic review and meta-analysis were done to compare the outcomes between the two groups.
Results: we included 9 studies with total of 1674 patients in this study. The pooled results in this meta-analysis showed equal long-term overall survival, Disease free survival, recurrence and mortality between the two groups (5-year OS, RR = 1.14, 95% CI = 0.96-1.35, P = 0.12; I2 = 56%), (5-year DFS, RR = 0.81, 95% CI = 0.61-1.08, P = 0.15; I2 = 60%), (Recurrence, RR =1.04, 95% CI = 0.94-1.15, P = 0.45; I2 = 27%), and (Mortality, RR =0.55, 95% CI = 0.26-1.15, P = 0.11; I2 = 0 %). In addition to that, no significant difference could be detected in the overall incidence of complications between the two groups (Complications, RR =0.94, 95% CI = 0.76-1.16, P = 0.57; I2 = 0 %).However, CH is associated with a remarkable increase in the rate of biliary fistula (Biliary fistula, RR =1.90, 95% CI = 1.07-3.40, P = 0.03; I2 = 0%). And Liver cell failure was higher in case of EH (LCF, RR =0.47, 95% CI = 0.30-0.76, P = 0.002; I2 = 0%). Regarding the operative details, CH is associated with longer operative time (Time of the operation, Mean difference = 0.82, 95% CI = 0.36, 1.27, P = 0.0004; I2 = 57%).
Conclusion: No significant difference in the short and long-term survival and recurrence between CH and MH for CL-HCC. However, CH is associated with greater future remnant liver volume that decreases the incidence of LCF and provides more opportunities for a repeat hepatectomy after tumor recurrence.
Diffuse pigmented villonodular synovitis treated with arthroscopic total synovial peel
Authors: Song Hao-Qiang , Wu Guo-Feng , Qi Wei-zhong , Lin Li-jun
Published: September 2022

Background: Diffuse pigmented villonodular synovitis (PVNS) is prone to recurrence after surgery, and it is difficult to achieve a long-term complete cure.
Objective: To reduce the recurrence rate of PVNS, the author pioneered the arthroscopic synovial peel procedure.
Methods: From March 2014 to July 2020, a total of 19 patients (6 males and 13 females) with diffuse PVNS of the knee were treated in our department and underwent arthroscopic total synovial peel (ATSP). It’s ‘peel’ rather than simple excision. This method is similar to peeling bark. Relapse rates and functional scores were determined, with follow-ups ranging from 12 to 72 months, on average 36 months.
Results: The results were assessed radiographically and functionally, and 2 cases (10.5%) recurred. Preoperative and postoperative functional scores were performed on patients without recurrence, and the average score increased after operation. Compared with the literature, ATSP significantly reduces the postoperative recurrence rate of diffuse PVNS. This approach was found to considerably minimize the recurrence rate of postoperative PVNS in follow-up investigations.
Conclusion: This approach may be a viable option for treating diffuse PVNS via arthroscopy and is worthy of clinical consideration.
Reducing the impact of cardiovascular disease in older people with cancer: a qualitative study of health care providers
Authors: KNOWLES Reegan , KEMP Emma , MILLER Michelle , KOCZWARA Bogda
Published: September 2022

Purpose: Cancer survivors are at greater risk of cardiovascular disease (CVD) than cancer-free controls. Despite evidence-based guidelines recommending CVD risk factor assessment, surveillance and risk-reduction, many people with cancer do not receive adequate CVD care. To address potential barriers and enablers of care, we examined health care professionals’ (HCP) perceptions and experiences of CVD risk assessment and management in people with cancer. Methods: We conducted one focus group and 12 individual interviews to examine HCPs’ perceptions and experiences of CVD care in care. We used reflexive thematic analysis to collect and analyse the qualitative data to construct and understand themes. Results: 21 HCPs participated (8 oncologists, 5 nurses, 3 general practitioners, 2 dietitians, 1 cardiologist, 1 haematologist and 1 physiotherapist). Majority HCPs were aware of CVD risk in cancer, but were concerned they could not deliver CVD care alone due to system-level barriers including lack of time and training. HCPs also perceived patient-level barriers including socioeconomic disadvantage and fatalistic outlook. Despite barriers, HCPs suggested diverse solutions for improving CVD care in cancer including new models-of-care, clinical pathways, risk assessment/management tools and education. Conclusions: The diversity of perceived barriers and suggested solutions identified by HCPs suggests the need for a multilevel approach tailored to context. Future research involving people with cancer is needed to co-design acceptable interventions. Implications for cancer survivors: Improved understanding of HCP’s perceptions can inform the development of new interventions to deliver CVD care to people with cancer to reduce morbidity and mortality.
Pre-calving energy density and rumen protected lysine impacted blood metabolites and biomarkers of liver functions in dairy cows during the transition period.
Authors: Delelesse Girma Debele , Ma Lu , Wang Fang , Callaway Toddy , Bu Dengpan
Published: September 2022

Dairy cow usual faces negative energy balance and disorder of normal organs function due to mismatch between energy intake and energy demands. Negative energy balance directly affects liver function and blood metabolites because of liver used as source of energy supply and center of metabolic activity. The study aimed to determine the effect of pre-calving energy density and rumen-protected lysine on blood metabolites and biomarkers of liver functions in dairy cows during the transition period. Forty 3rd lactation Holstein cows were randomly allocated to one of the four dietary treatments (High energy with rumen-protected lysine (HERPL) = 1.53NEL plus 40 g Lys, High energy without lysine (HECK) = 1.53NEL, Low energy with rumen-protected lysine (LERPL) = 1.37NEL plus 40 g Lys, and Low energy without lysine (LECK) = 1.37NEL arranged in a 2 x 2 factorial design. Blood samples were collected during the transition period and concentrations of blood metabolites and biomarkers of liver functions were measured. Interaction between pre-calving high energy diet and RPL tended to increase plasma albumin, numerically increased glucose, decreased TG, total bilirubin and AST concentrations. The result revealed that pre-calving high energy diet increased insulin, albumin and decreased blood urea nitrogen and total bilirubin concentrations and substantial favor liver functions during the transition period.
Low Prognostic Nutritional Index Contributes to High Risk of Adverse Events in Patients Undergoing Surgical Valve Replacement
Authors: Lian Liyou , Yao Hongxia , Zheng Rujie , Wang Kaijing , Hu Xiang , Chen Chen
Published: September 2022

Background Prognostic nutritional index (PNI) score is a useful indicator to evaluate the nutritional status of patients. However, the nutritional significance of the PNI score and its ability to predict clinical prognosis in patients with surgical valve replacement (SVR) are unknown. The goal of this study was to analyze the association between PNI on admission and adverse events in patients following SVR.Methods This study included 485 patients who underwent successful SVR. Baseline PNI score was calculated before SVR on admission. The patients were divided into high and low PNI groups according to the cut-off value of PNI using the receiver operating characteristic (ROC) curve. Primary outcomes were composite adverse events, defined as worsening heart failure, myocardial infarction, major bleeding, uncontrolled infection, second surgery, post-operative arrhythmia or all-cause death during the follow-up. The association of PNI score and primary outcomes was presented as hazard ratios (HR) with 95% confidence intervals (CI) calculated by adverse events in the crude and multivariate-adjusted Cox Proportional Hazards models.Results Overall, adverse events were observed in 61(13%) patients. ROC curves revealed an area under curve of 0.676 for PNI with a cut-off of 46. The cumulative event rate by Kaplan–Meier analysis was higher in low PNI group (P < 0.001). Adjusted multivariate analysis showed that low PNI was associated with adverse outcomes (HR: 2.303, 95% CI: 1.338-3.964, P = 0.003). Conclusion Low PNI on admission in patients with SVR was associated with higher incidence of clinical adverse events. Using the PNI score to identify individuals with poor nutritional status might be an important method for clinical prognosis prediction, and improving nutritional status during follow-up might help to reduce the risks of adverse outcomes in these patients.
Factors Associated with Risk of NAFLD and Progression in Multiethnic Asians. A Latent Class and Machine Learning Analysis
Authors: Ng Cheng Han , Nah Benjamin , Kaewdech Apichat , Aung Hlaing Bwa , Mak Lung-Yi , Kulkarni Anand V , Muthiah Mark
Published: September 2022

Introduction

Non-alcoholic fatty liver disease (NAFLD) is the commonest liver condition globally. However, Asians with NAFLD are significantly different from the west. Despite the significant prevalence of the disease, studies on Asians particularly from southeast Asians are lacking. Herein, we examine the prevalence, risk factors and different classes of NAFLD based on a multicenter cohort study from five centers in Asia.

Methods

A multicenter study involving the use of vibration-controlled transient elastography (VCTE) for the assessment of NAFLD based on a cutoff of ≥ 288 dB/m and liver fibrosis was examined through liver stiffness measures (LSM). Risk factors were examined through risk ratios (RR) from a generalized linear model and gradient boosting machines (GBM) machine learning model. A latent class analysis (LCA) was additionally conducted to explore subtypes of NAFLD in Asia.

Results

Of the 1,686 individuals included in the analysis, a total of 822 individuals were identified to have NAFLD. Factors that were associated with an increased risk of NAFLD included male gender, elevated serum lipid levels and diagnosis of hypertension or diabetes mellitus with similar findings from GBM. LCA identified two subtypes of NAFLD. Class 1 LCA had lower rates of metabolic dysfunction and were more likely lean relative to Class 2 LCA. However, both classes were at similar risk of clinically significant fibrosis and advance fibrosis. The risk of cirrhosis was higher in Class 1 LCA.

Discussion

The current analysis describes the prevalence and risk factors of NAFLD in a multiethnic Asian cohort with conventional regression and GBM analysis. Subclasses of NAFLD identified from LCA found that patients with lower rates of metabolic dysfunction had similar if not increased rates of fibrosis.
Nitrogen Transformation Processes in Manure Microbiomes of Earthen Pit and Concrete Storages on Commercial Dairy Farms
Authors: Khairunisa Bela Haifa , Loganathan Usha , Ogejo Jactone A. , Mukhopadhyay Biswarup
Published: September 2022

Storing manure is an essential aspect of nutrient management on dairy farms, presenting the opportunity to use it effectively as a fertilizer in crop and pasture production. The storage structures are earthen, concrete, or steel-based constructs. However, this practice presents the potential of losing nitrogen (fertilizer value) and emitting greenhouse gases (environmental stressors) to the atmosphere through microbial and physicochemical processes. We have conducted a study to characterize the relevant microbial processes in two manure storage structures, a clay lined earthen pit and an above-ground concrete storage tank, on commercial dairy farms, to inform the development of mitigation practices to preserve the value of manure. First, we analyzed the 16S rRNA-V4 amplicons generated from manure samples collected from several locations and depths (0.3, 1.2 and 2.1–2.75 meters below the surface) of the storages, identifying a set of OTUs and quantifying their abundances. Then, we inferred the respective metabolic capabilities. These results showed that the manure microbiome composition was more complex and exhibited more location-to-location variation in the earthen pit than in the concrete tank. Further, the inlet and a location with hard surface crust in the earthen pit had unique consortia. The microbiomes in both storages had the potential to generate ammonia but lacked the organisms for oxidizing it to gaseous compounds. However, the microbial conversion of nitrate to emittable N2, NO, and N2O via denitrification and to stable ammonia via dissimilatory nitrite reduction seemed possible; minor quantities of nitrate was present in manure, potentially originating from oxidative processes occurring on barn floor. The nitrate-transformation linked OTUs were more prevalent at the near-surface locations and all depths of the inlet. No anammox bacteria and autotrophic nitrifiers, archaeal or bacterial, were detected in both storages. HydrogenotrophicMethanocorpusculumspecies were the primary methanogens or methane producers, exhibiting higher abundance in the earthen pit. These findings suggested that microbial activities were not the main drivers for nitrogen loss from manure storage, and commonly reported losses are associated with the physicochemical processes. Finally, the microbiomes of stored manure had the potential to emit greenhouse gases such as NO, N2O, and methane.
Efficacy and safety of prone position in COVID-19 patients with respiratory failure: A systematic review and meta-analysis
Authors: Lee Hyeon-Jeong , Kim Junghyun , Choi Miyoung , Choi Won-Il , Joh Joonsung , Park Jungeun , Kim Joohae
Published: September 2022

Background:Prone position has already been demonstrated to improve survival in non-COVID acute respiratory distress syndrome. It has been widely performed in COVID-19 patients with respiratory failure, both in non-intubated and intubated patients. However, the beneficial effect of the prone position in COVID-19 pneumonia still remains unclear. Therefore, we aimed to evaluate the effectiveness and safety of the prone position compared with the non-prone in COVID-19 patients. Methods:We searched the MEDLINE, EMBASE, and Cochrane databases, as well as one Korean domestic database, on July 9, 2021, and updated the search monthly to February 10, 2022. Studies that compared prone and non-prone positions in patients with COVID-19 were eligible for inclusion. The primary outcomes were mortality, need for intubation, and adverse events. The secondary outcomes were the length of stay (LOS) in the hospital or intensive care unit (ICU), ICU-free days, and ventilator-fee days. Subgroup analysis was performed based on the oxygen delivery methods. Results:Of the 1,179 records identified, 4 randomized controlled trials (RCTs) and 16 cohort studies were eligible. In cohort studies, the mortality was not different between the prone and non-prone groups in intubated patients, but the prone position showed a significant survival benefit in the non-intubated patient group regardless of the oxygen delivery method (13 studies, n=2,519; relative risk [RR] 0.59, 95% CI 0.47 to 0.76, P<0.0001, I2=48%). In addition, the prone position reduced the intubation rate in RCTs (3 studies, n=1,256, RR 0.83, 95% CI 0.71 to 0.97, P=0.02) compared with the non-prone position. In both RCTs and cohort studies, there were no significant differences in LOS in the ICU or hospital, ICU-free days, or ventilator-free days between the prone and non-prone positions. Adverse events were mild and similar between the two groups.Conclusion:In non-intubated patients with COVID-19, prone positioning reduced the risk of intubation in patients requiring a high-flow oxygen system and improved survival with similar adverse event rates. Therefore, the prone position should be encouraged in non-intubated COVID-19 patients. However, insufficient evidence supports the beneficial effects of prone positioning in intubated patients.Registration: This study was registered in the Prospective Register of Systematic Reviews on February 16, 2022 (registration number: CRD42022311150).
FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion
Authors: Yan Guijun , Cao Zhiwen , Yan Qiang , Zhang Mei , Zhu Yingchun , Liu Jingyu , Jiang Yue , Zhen Xin , Xu Manlin , Yue Qiuling , Zhou Jidong , Zhou Quan , Wang Xiaoying , Ding Lijun , Sun Haixiang
Published: September 2022

Recurrent implantation failure (RIF) is a rather thorny problem in the clinical practice of assisted reproductive technology. Due to the complex aetiology of RIF, its pathogenesis is far from fully understood, and there is no effective treatment available. Here, We explored the regulatory mechanism of the four half-domains of LIM domain 1 (FHL1), which is significantly downregulated in the endometrium of RIF patients, in blastocyst-epithelial adhesion. Indeed, FHL1 expression was dramatically increased in normal female mid-secretory endometrial epithelial cells and was abnormally reduced in RIF patients. Furthermore, FHL1 overexpression promoted blastocyst-epithelial adhesion, and interfering with FHL1 expression in the mouse uterus significantly inhibited embryo implantation. Mechanistically, FHL1 did not regulate HOXA10 mRNA expression but increased HOXA10 protein stability and activated HOXA10, thereby promoting its regulation of downstream gene expression and the β3 integrin/FAK pathway. Meanwhile, FHL1 regulates HOXA10 function by increasing HOXA10 deacetylation through enhanced binding of HOXA10 and SIRT2. SIRT2-specific inhibitors can significantly inhibit this effect. In the endometrial epithelial cells of RIF patients, the correlation between FHL1 and HOXA10 and its downstream target genes has also been verified. Finally, our data indicated FHL1 is a regulatory molecule that promotes blastocyst-epithelial adhesion. Altogether, downstream dysfunction due to aberrant FHL1 expression is an important molecular basis for embryo implantation failure in patients with RIF and to provide new potential therapeutic targets.
Leveraging on traditional practices to address contemporary healthcare inequities: a case of Kisiizi Community-based Health Insurance Scheme.
Authors: Kakama Alex Ayebazibwe , Atuheire Ambrose , Kahyana Danson
Published: September 2022

Engozi, a traditional health and social-services system has
existed for centuries in southwestern Uganda. Members contributed
funds for: healthcare, transport for patients to hospitals and
burial ceremonies for members. Membership focused on clanship or
neighbourhood. The establishment of “free public healthcare
services” led to the decline of the engozi system. However, due to
inadequate government resource allocation to health sector, the
government health services cannot meet the needs of the rural
communities. Equitable access to healthcare is still unachievable
even after the abolition of user fees. Cost of services is still a
key barrier, and the poor have limited access to quality healthcare
services. CBHI was fronted as one strategy to address such
inequities. In 1996, the Kisiizi community leveraged on the engozi
groups’ traditions to establish the first Community-based Health
Insurance (CBHI) Scheme in Uganda, promoting access to quality
healthcare at a low cost. CBHI has been successful in reducing
out-of-pocket payments, obtaining financial protection against
catastrophic health expenditures and improving access to healthcare
in low-income communities. The goal of this study was to explore
the significance of community values and traditions in addressing
healthcare inequities through a CBHI approach. This study adopted a
case study methodology and qualitative methods., The study was
guided by Woolcock’s social capital theory.

Conclusion: This paper affirms that communities characterized
by solid intra-community ties are more likely to experience success
with CBHI. It adds that compliance to society values and
traditions; and active involvement of community leaders in the
planning and execution of CBHI are essential determinants of
success. Consequently, the CBHI scheme addresses contemporary
healthcare inequities through; breaking financial barriers to
accessing quality healthcare, promoting early healthcare-seeking
behavior, and leads to increased equity in healthcare access and
utilization.
Susceptibility of Neohelice granulata (Decapoda, Varunidae) to White Spot Syndrome Virus (WSSV)
Authors: Moser Juliana Righetto , Marques Maria Risoleta Freire
Published: September 2022

White Spot Syndrome Virus (WSSV) continues to be the most severe viral pathogen to the shrimp industry worldwide. Pacific white shrimp Litopenaeus vannamei is particularly affected by WSSV and this virus has been detected in a wide range of wild crustaceans, including penaeid and non-penaeid shrimp, crayfish, as well as crabs. Crabs have been considered as a dangerous threat to shrimp farms because they are generally believed to be highly tolerant to WSSV and to remain infected for long periods without signs of disease. The burrowing crab Neohelice (= Chasmagnathus) granulata can be commonly found in the surroundings of the shrimp farms in southern Brazil. Here, we investigated the susceptibility of N. granulata to WSSV infection in comparison to L. vannamei. WSSV infectability and host susceptibility were investigated by viral challenge (intramuscular injection) in both species. Viral load in challenged animals was quantified by qPCR in both hemolymph and gills. Furthermore, the transcript levels of sixteen target genes related to the molecular defense status were assessed. The results revealed that N. granulate experimentally infected by WSSV, as well as those naturally infected, showed lethargy, lack of appetite and later gross signs of the disease. Moreover, N. granulate showed to be less susceptible to WSSV when compared to L. vannamei. While no death was observed in crabs before a post-challenge interval of 120 h; shrimp death was seen as early as 48 hours post-infection. Comparative viral load was also assessed by qPCR in gills of captured wild crabs and farmed shrimp naturally infected by WSSV. Transcript levels of target genes were also investigated after WS-challenge between 24 and 48 hpi in shrimp and between 96 and 120 hpi in crab. Differences in gene transcripts were particularly noteworthy with the increase of viral copies at 106 copies.µl− 1. These results indicated that WSSV infection modulated genes related of important cellular responses, such as apoptosis, chaperone function and ion storage, in both shrimp and crab.
Ventral and dorsal aspects of the inferior frontal-occipital fasciculus support verbal semantic access and visually-guided behavioural control
Authors: Alam Tirso RJ Gonzalez , Arias Juan Cruz , Jefferies Elizabeth , Smallwood Jonathan , Davolos Julian Marino
Published: September 2022

The Inferior Frontal Occipital Fasciculus (IFOF) is a major anterior-to-posterior white matter pathway in the ventral human brain that connects parietal, temporal and occipital regions to frontal cortex. It has been implicated in a range of functions, including language, semantics, inhibition and the control of action. Recent research shows that the IFOF can be sub-divided into a ventral and dorsal branch, but the functional relevance of this distinction, as well as any potential hemispheric differences, are poorly understood. Using DTI tractography, we investigated the involvement of dorsal and ventral subdivisions of the IFOF in the left and right hemisphere in a response inhibition task (Go/No-Go), where the decision to respond or to withhold a prepotent response was made on the basis of semantic or non-semantic aspects of visual inputs. The task also varied the presentation modality (whether concepts were presented as written words or images). The results showed that the strength of both dorsal and ventral IFOF in the left hemisphere were associated with participants’ inhibition performance when the signal to stop was meaningful and presented in the verbal modality. This effect was absent in the right hemisphere. The strength of dorsal IFOF was also associated with participants’ inhibition efficiency in difficult perceptually guided decisions. This pattern of results indicates that left dorsal IFOF is implicated in the domain-general control of visually-guided behaviour, while the left ventral branch might interface with the semantic system to support the control of action when the inhibitory signal is based on meaning.
Preparation of High Purity and Whiteness gypsum from Phosphogypsum for CO 2 Mineral Sequestration
Authors: Zhang Man , Fan Xing
Published: September 2022

Phosphogypsum (PG) is a solid waste produced in the production process of wet-process phosphoric acid. Due to the inclusion of various impurities, the purity and whiteness of PG has been greatly reduced, and the application range of phosphogypsum is also limited. This article analyzes the physical properties of PG in detail, and systematically studies the content and distribution of impurities. Based on this, a simple process to efficiently remove almost all impurities in the PG was proposed. The results showed that the purity and whiteness of the purified gypsum(CaSO4) significantly increased to 99% and 92%, respectively. The migration of impurities and the material balance of this process was analyzed. Most importently, the purified gypsum showed high CO2 sequestration efficiency for CO2 mineral sequestration and through which high value added CaCO3 product can be obtained.
Consolidation behavior of various types of slurry tailings co-disposed with waste rock inclusions: a numerical study
Authors: Nguyen Ngoc Dung , Pabst Thomas
Published: September 2022

The co-disposition of mine tailings and waste rock in tailings storage facilities (TSFs) could contribute to increase the consolidation rate and decrease long-term settlement of tailings. Non-linear change of tailings properties during the filling process and interaction between tailings and waste rock inclusion (WRI) are critical to mechanical analysis but can, however, be complicated to simulate. The question of net volume gains or losses of tailings was also raised. In this study, fully coupled analysis which considered continuous variation of hydraulic conductivity and stiffness of tailings were performed to assess the evolution of consolidation of various tailing types in the presence of WRI. Effects of volume ratio of tailings over WRI on the net volume was investigated. Finally, effect of several practical aspects such as filling rates, and instantaneous filling assumption were considered. Results indicated that WRI could increase by 3.3 times the rate of consolidation of tailings. The zone of influence of WRI on tailings consolidation varied for each tailings. Using updated properties showed significant differences compared to models with constant values. The application of WRI can reduce volume available for the storage of tailings and net volumetric change due to settlement of the tailings with or without WRI could be estimated explicitly. Equations predicting evolution of net volume with the changes in the volume ratio of tailings and WRI were accordingly proposed. WRI effects was more pronounced with the increase of the filling rate. Finally, instantaneous filling assumption had little effect on the simulated rate of consolidation.
Role of apelin in vascular smooth muscle cell phenotypic transition: a proatherogenic factor for atherosclerosis
Authors: Santos Luís Miguel Cardoso Dos , Azar Pascal , Brun Cécile , König Stéphane , Roatti Angela , Baertschi Alex J , Chaabane Chiraz , Bochaton-Piallat Marie-Luce
Published: September 2022

Background. During atherosclerotic plaque formation smooth muscle cells (SMCs) switch from a contractile/differentiated to a synthetic/dedifferentiated phenotype We previously isolated differentiated spindle-shaped (S) and dedifferentiated rhomboid (R) SMCs from porcine coronary artery. R-SMCs express S100A4, a calcium binding protein.
Aim. We investigated the role of apelin in this phenotypic conversion, as well as its relationship with S100A4.
Results. We found that apelin was highly expressed in R-SMCs compared with S-SMCs. We observed a nuclear expression of apelin in SMCs within experimentally-induced intimal thickening of the porcine coronary artery and rat aorta. Plasmids targeting apelin to the nucleus (N. Ap) and to the secretory vesicles (S. Ap) were transfected into S-SMCs where apelin was barely detectable. Both plasmids induced the SMC transition towards a R-phenotype. Overexpression of N. Ap, and to a lesser degree S. Ap, led to a nuclear localization of S100A4. Stimulation of S-SMCs with platelet-derived growth factor-BB, known to induce the transition toward the R-phenotype, yielded nuclear expression of both apelin and S100A4.
Conclusion. Apelin induces a SMC phenotypic transition towards the synthetic phenotype. These results suggest that apelin acts via nuclear re-localization of S100A4, raising the possibility of a new complex pro-atherogenic relationship between apelin and S100A4.
Treatment burden for older people with multimorbidity: a cross-sectional study in China
Authors: Dou Liyuan , Jiang Qiuling , Duncan Polly , Li Xiaoping
Published: September 2022

Background: There has been little research in China about treatment burden. Studies internationally have found high treatment burden is associated with number of long-term conditions, low quality of life (QoL) iand poor medication adherence. The purpose of this study is to understand factors associated with high treatment burden for older people with multimorbidity in China. Methods：A cross-sectional survey was conducted from February to May 2022. Through convenience sampling, 353 older people (≥60 years) with multimorbidity (≥2 long-term conditions) admitted to hospital in Zhengzhou, China, were invited to complete a survey including sociodemographic characteristics, long-term conditions and the Chinese version of Multimorbidity Treatment Burden Questionnaire (C-MTBQ). Ordinal logistic regression was used to identify the factors associated with high treatment burden.Results： 342 older people with multimorbidity participated (response rate 92.2%) among whom, the prevalence of no，low，medium, and high treatment burden was 1.2% (4/342)，13.9% (44/342)，49.1% (168/342)，and 36.8% (126/342), respectively. Ordinal logistic regression analysis found high treatment burden was associated with age, monthly household income，type of medical insurance，and number of long-term conditions.Conclusion：Most surveyed older people with multimorbidity experienced medium-to-high treatment burden. Interventions to reduce treatment burden for people with multimorbidity in China, should focus particularly on people at risk of higher treatment burden, namely older people with low income and high number of long-term conditions.
Photon trapping in a time cavity flying with a speed of light
Authors: Babushkin Ihar , Melchert Oliver , Morgner Uwe , Demircan Ayhan
Published: September 2022

A refractive index step, moving at the speed of light, can serve as a trap for weak light waves. Here we shed light on highly unusual features of such trapping, making it fundamentally different from conventional “resting” cavities. First, such trapping can be described as time-tapping rather than space-trapping. Trapping in time provides superior quality Q, but this quality does not anymore impose very narrow spectral lines, breaking thereby the fundamental time-bandwidth limit inherent to most traps of any physical nature. Although the trapped states are almost entirely disconnected from the outer world, a nonreciprocal connection channel involving resonant radiation can be opened and tunably manipulated. Nonreciprocity breaks the balance between the energy currents directed into the trap and back, allowing to load the trap faster than it is possible for reciprocal systems. Exotic, up to now unobserved in optics states such as halo states, and phenomena as anomalously huge delays in transmission occur naturally in a time trap. Beatings between the trapped-in-time modes provide a novel tool for ultrafast shaping of both spectral and temporal waveforms for arbitrary weak wavepackets, even for single photons. Altogether, this promises a highly eﬀicient platform for energy storage, pulse compression, waveform shaping and frequency conversion for ultrafast classical and quantum optics.
Diagnosis of Two-axis Cylindrical Grinder Machining Error
Authors: Roy Rohit , Chieng Wei-Hua , Wu Pei-Sheng , Chiang Chung-Ping
Published: September 2022

This paper attempts to develop a diagnosis method for classifying the machining error sources on the external/internal contour surfaces which are fabricated using a two-axis cylindrical grinding machine. A derivation of the contour profile to grinding wheel motion trajectory and also the grinding wheel motion trajectory to the contour profile equations has been performed. Due to the contours having a sinusoidal polynomial curve instead of a rose curve, the grinding wheel motion trajectory equation is then used to generate the NC code for the machining. The grinding wheel motion trajectory equation is needed for the synthesis of the profile error caused by the motion error as well as the variation of the grinding wheel diameter. The two-axis motion equation is obtained by transforming the non-circular contour equation through the coordinates of the grinding wheel and workpiece. The influence of different machining parameters such as grinding wheel outer diameter error, grinding wheel feed rate, workpiece rotation speed on the external/internal contour profile is being studied and analyzed. The diagnosis method is based on the least square method to assemble the components of the profile error due to each individual error sources. The actual machining with probe system is used to verify the diagnosis result.
Coal–gangue recognition via Multi–branch convolutional neural network based on MFCC in noisy environment
Authors: Jiang HaiYan , Zong DaShuai , Gao KuiDong , Song QingJun , Shao HuZhi , Liu ZhiJiang
Published: September 2022

This paper mainly studies the more accurate recognition of coal–gangue in the noise site environment in the process of top coal caving. Mel Frequency Cepstrum Coefficients (MFCC) smoothing method was introduced in the coal–gangue recognition site. Then, a convolution neural network model with three branches was developed. Experiments show that the proposed coal–gangue recognition method based on multi branch convolution neural network and MFCC smoothing can not only recognize the state of falling coal or gangue, but also recognize the operational state of site device.