bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Impact of Social and Built Environment Factors on Body Size among Breast Cancer Survivors: The Pathways Study
Authors: Shariff-Marco Salma , Von Behren Julie , Reynolds Peggy , Keegan Theresa H.M. , Hertz Andrew , Kwan Marilyn L. , Roh Janise M. , Thomsen Catherine , Kroenke Candyce H. , Ambrosone Christine , Kushi Lawrence H. , Gomez Scarlett Lin
Published: April 2023

Abstract
Background: As social and built environment factors have been shown to be associated with physical activity, dietary patterns, and obesity in the general population, they likely also influence these health behaviors among cancer survivors and thereby impact survivorship outcomes.

Methods: Enhancing the rich, individual-level survey and medical record data from 4,505 breast cancer survivors in the Pathways Study, a prospective cohort drawn from Kaiser Permanente Northern California, we geocoded baseline residential addresses and appended social and built environment data. With multinomial logistic models, we examined associations between neighborhood characteristics and body mass index and whether neighborhood factors explained racial/ethnic/nativity disparities in overweight/obesity.

Results: Low neighborhood socioeconomic status, high minority composition, high traffic density, high prevalence of commuting by car, and a higher number of fast food restaurants were independently associated with higher odds of overweight or obesity. The higher odds of overweight among African Americans, U.S.-born Asian Americans/Pacific Islanders, and foreign-born Hispanics and the higher odds of obesity among African Americans and U.S.-born Hispanics, compared with non-Hispanic whites, remained significant, although somewhat attenuated, when accounting for social and built environment features.

Conclusions: Addressing aspects of neighborhood environments may help breast cancer survivors maintain a healthy body weight.

Impact: Further research in this area, such as incorporating data on individuals' perceptions and use of their neighborhood environments, is needed to ultimately inform multilevel interventions that would ameliorate such disparities and improve outcomes for breast cancer survivors, regardless of their social status (e.g., race/ethnicity, socioeconomic status, nativity). Cancer Epidemiol Biomarkers Prev; 26(4); 505–15. ©2017 AACR.

See all the articles in this CEBP Focus section, “Geospatial Approaches to Cancer Control and Population Sciences.”
Data from Farm Characteristics, Allergy Symptoms, and Risk of Non-Hodgkin Lymphoid Neoplasms in the Agricultural Health Study
Authors: Hofmann Jonathan N. , Hoppin Jane A. , Lynch Charles F. , Poole Jill A. , Purdue Mark P. , Blair Aaron , Alavanja Michael C. , Beane Freeman Laura E.
Published: April 2023

Abstract
Background: Because of unique exposures, studies among farmers may yield insights into the relationship between allergies and non-Hodgkin lymphoid (NHL) neoplasms. We evaluated farm characteristics, allergic symptoms and conditions, and risk of NHL including specific subtypes in the Agricultural Health Study, a prospective cohort of farmers and spouses from North Carolina and Iowa.

Methods: We identified 710 incident cases of NHL (including chronic lymphocytic leukemia and multiple myeloma) among 82,370 participants with baseline data on crop and animal exposures, including 454 cases among 52,850 participants with baseline data on recent allergy symptoms (rhinitis) and living on a farm during childhood. HR and 95% confidence intervals (CI) were calculated using multivariable-adjusted proportional hazards models.

Results: We observed reduced risks of NHL among farmers and spouses with rhinitis at baseline (HR, 0.63; 95% CI, 0.51–0.79), related to growing soybeans (HR, 0.80; 95% CI, 0.67–0.96), and among farmers who handled stored grains or hay (HR, 0.66; 95% CI, 0.52–0.82). Growing up on a farm was associated with increased NHL risk (HR, 1.51; 95% CI, 1.15–1.98). Results did not differ significantly by NHL subtype.

Conclusions: Both the reduced risk of NHL among those with allergy symptoms and specific farm exposures in adulthood, and the increased risk among those who grew up on a farm suggest that the host immune response to agricultural allergens may influence NHL development.

Impact: This prospective study is, to our knowledge, the first to investigate the relationship between allergy symptoms and NHL risk in farmers; confirmation of these findings in other farming populations is warranted. Cancer Epidemiol Biomarkers Prev; 24(3); 587–94. ©2015 AACR.
Data from Geospatial Patterns in Human Papillomavirus Vaccination Uptake: Evidence from Uninsured and Publicly Insured Children in North Carolina
Authors: Trogdon Justin G. , Ahn Thomas
Published: April 2023

Abstract
Background: Human papillomavirus (HPV) vaccination coverage is far below the national objective set by Healthy People 2020. This paper explores spatial patterns in HPV vaccination uptake.

Methods: Secondary data for publicly funded HPV vaccinations among age-eligible children from 2008 through 2013 from the North Carolina Immunization Registry (NCIR) were used in 2014 in an ecological analysis at the ZIP code tabulation area (ZCTA) level. We tested for spatial autocorrelation in unadjusted HPV vaccination rates using choropleth maps and Moran's I. We estimated nonspatial and spatial negative binomial models with spatially correlated random effects adjusted for demographic, economic, and healthcare variables drawn from the 2010 U.S. Census Bureau, 2008–2012 American Community Survey, 2010 ZIP Business Patterns, and the 2012–2013 Area Resource File.

Results: The NCIR revealed areas of especially low rates in publicly funded HPV vaccinations among uninsured and means-tested, publicly insured children. For boys, but not girls, ZCTAs tended to have HPV vaccination rates that were similar to their neighbors. This result was partially explained by included ZCTA characteristics, but not wholly.

Conclusions: To the extent that the geospatial clustering of vaccination rates is due to causal influences from one ZCTA to another (e.g., through information networks), targeting interventions to increase HPV vaccination in one area could also lead to increases in neighboring areas.

Impact: Spatial targeting of HPV vaccination, especially in clusters of low vaccination areas, could be an effective strategy to reduce the spread of HPV and related cancers. Cancer Epidemiol Biomarkers Prev; 24(3); 595–602. ©2015 AACR.
Data from Longitude Position in a Time Zone and Cancer Risk in the United States
Authors: Gu Fangyi , Xu Shangda , Devesa Susan S. , Zhang Fanni , Klerman Elizabeth B. , Graubard Barry I. , Caporaso Neil E.
Published: April 2023

Abstract
Background: Circadian disruption is a probable human carcinogen. From the eastern to western border of a time zone, social time is equal, whereas solar time is progressively delayed, producing increased discrepancies between individuals' social and biological circadian time. Accordingly, western time zone residents experience greater circadian disruption and may be at an increased risk of cancer.

Methods: We examined associations between the position in a time zone and age-standardized county-level incidence rates for total cancers combined and 23 specific cancers by gender using the data of the Surveillance, Epidemiology, and End Results Program (2000–2012), including four million cancer diagnoses in white residents of 607 counties in 11 U.S. states. Log-linear regression was conducted, adjusting for latitude, poverty, cigarette smoking, and state. Bonferroni-corrected P values were used as the significance criteria.

Results: Risk increased from east to west within a time zone for total and for many specific cancers, including chronic lymphocytic leukemia (both genders) and cancers of the stomach, liver, prostate, and non-Hodgkin lymphoma in men and cancers of the esophagus, colorectum, lung, breast, and corpus uteri in women.

Conclusions: Risk increased from the east to the west in a time zone for total and many specific cancers, in accord with the circadian disruption hypothesis. Replications in analytic epidemiologic studies are warranted.

Impact: Our findings suggest that circadian disruption may not be a rare phenomenon affecting only shift workers, but is widespread in the general population with broader implications for public health than generally appreciated. Cancer Epidemiol Biomarkers Prev; 26(8); 1306–11. ©2017 AACR.
Data from Exposure to Diagnostic Radiological Procedures and the Risk of Childhood Acute Lymphoblastic Leukemia
Authors: Bailey Helen D. , Armstrong Bruce K. , de Klerk Nicholas H. , Fritschi Lin , Attia John , Lockwood Liane , Milne Elizabeth
Published: April 2023

Abstract
Background: Diagnostic irradiation of the mother during pregnancy increases the risk of childhood acute lymphoblastic leukemia (ALL). There is inconsistent evidence on associations between ALL and other parental or childhood diagnostic irradiation. The aim of this analysis is to investigate whether diagnostic X-rays of the mother before birth, of the father before conception, or of the child increased the risk of childhood ALL.

Methods: Data from 389 cases and 876 frequency-matched controls were analyzed using unconditional logistic regression, adjusting for study matching factors and potential confounders. A meta-analysis of our findings in relation to paternal X-rays before conception with the published findings of previous studies was also conducted.

Results: There was no evidence of an increased risk with maternal abdominal X-rays before the birth of the index child or with the child having any X-rays more than 6 months before the censoring date. The odds ratio (OR) for any paternal abdominal X-ray before conception was 1.17 [95% confidence interval (95% CI), 0.88-1.55], and 1.47 (95% CI, 0.98-2.21) for more than one X-ray. The OR for any paternal intravenous pyelogram before conception was 3.56 (95% CI, 1.59-7.98). The pooled OR for this study with previous studies of any paternal abdominal X-rays before conception was 1.17 (95% CI, 0.92-1.48).

Conclusions: There was some evidence of an increased risk of ALL in the offspring if the father had more than one abdominal X-ray before conception or had ever had an intravenous pyelogram.

Impact: We plan to repeat this analysis by using pooled data to improve precision. Cancer Epidemiol Biomarkers Prev; 19(11); 2897–909. ©2010 AACR.
Data from Temporal Trends in Colorectal Cancer Screening among Asian Americans
Authors: Fedewa Stacey A. , Sauer Ann Goding , Siegel Rebecca L. , Smith Robert A. , Torre Lindsey A. , Jemal Ahmedin
Published: April 2023

Abstract
Asian Americans (AA) are less likely to be screened for colorectal cancer compared with non-Hispanic Whites (NHW), with a widening disparity for some AA subgroups in the early 2000s. Whether these patterns have continued in more recent years is unknown. We examined temporal trends in colorectal cancer screening among AA overall compared with NHWs and by AA subgroup (Chinese, Japanese, Korean, Filipino, South Asian, Vietnamese) using data from the 2003, 2005, 2007, and 2009 California Health Interview Surveys. Unadjusted (PR) and adjusted (aPR) prevalence ratios for colorectal cancer screening, accounting for sociodemographic, health care, and acculturation factors, were calculated for respondents ages 50 to 75 years (NHW n = 60,125; AA n = 6,630). Between 2003 and 2009, colorectal cancer screening prevalence increased from 43.3% to 64.6% in AA (P ≤ 0.001) and from 58.1% to 71.4% in NHW (P ≤ 0.001). Unadjusted colorectal cancer screening was significantly lower among AA compared with NHW in 2003 [PR = 0.74; 95% confidence interval (CI), 0.68–0.82], 2005 (PR = 0.78; 95% CI, 0.72–0.84), 2007 (PR = 0.91; 95% CI, 0.85–0.96), and 2009 (PR = 0.90; 95% CI, 0.84–0.97), though disparities narrowed over time. After adjustment, there were no significant differences in colorectal cancer screening between the two groups, except in 2003. In subgroup analyses, between 2003 and 2009, colorectal cancer screening significantly increased by 22% in Japanese, 56% in Chinese, 47% in Filipino, and 94% in Koreans. In our study of California residents, colorectal cancer screening disparities between AA and NHW narrowed, but were not eliminated and screening prevalence among AA remains below nationwide goals, including the Healthy People 2020 goal of increasing colorectal cancer screening prevalence to 70.5%. Cancer Epidemiol Biomarkers Prev; 25(6); 995–1000. ©2016 AACR.
Data from Diagnostic Metabolomic Blood Tests for Endoluminal Gastrointestinal Cancer—A Systematic Review and Assessment of Quality
Authors: Antonowicz Stefan , Kumar Sacheen , Wiggins Tom , Markar Sheraz R. , Hanna George B.
Published: April 2023

Abstract
Advances in analytics have resulted in metabolomic blood tests being developed for the detection of cancer. This systematic review aims to assess the diagnostic accuracy of blood-based metabolomic biomarkers for endoluminal gastrointestinal (GI) cancer. Using endoscopic diagnosis as a reference standard, methodologic and reporting quality was assessed using validated tools, in addition to pathway-based informatics to biologically contextualize discriminant features. Twenty-nine studies (15 colorectal, 9 esophageal, 3 gastric, and 2 mixed) with data from 10,835 participants were included. All reported significant differences in hematologic metabolites. In pooled analysis, 246 metabolites were found to be significantly different after multiplicity correction. Incremental metabolic flux with disease progression was frequently reported. Two promising candidates have been validated in independent populations (both colorectal biomarkers), and one has been approved for clinical use. Networks analysis suggested modulation of elements of up to half of Edinburgh Human Metabolic Network subdivisions, and that the poor clinical applicability of commonly modulated metabolites could be due to extensive molecular interconnectivity. Methodologic and reporting quality was assessed as moderate-to-poor. Serum metabolomics holds promise for GI cancer diagnostics; however, future efforts must adhere to consensus standardization initiatives, utilize high-resolution discovery analytics, and compare candidate biomarkers with peer nonendoscopic alternatives. Cancer Epidemiol Biomarkers Prev; 25(1); 6–15. ©2015 AACR.
Data from Sleep Duration and Disruption and Prostate Cancer Risk: a 23-Year Prospective Study
Authors: Markt Sarah C. , Flynn-Evans Erin E. , Valdimarsdottir Unnur A. , Sigurdardottir Lara G. , Tamimi Rulla M. , Batista Julie L. , Haneuse Sebastien , Lockley Steven W. , Stampfer Meir , Wilson Kathryn M. , Czeisler Charles A. , Rider Jennifer R. , Mucci Lorelei A.
Published: April 2023

Abstract
Background: Sleep deficiency is a major public health problem. There are limited human data on whether sleep duration or disruption are risk factors for prostate cancer.

Methods: We prospectively followed 32,141 men in the Health Professionals Follow-Up Study who reported their typical sleep duration in 1987, 2000, and 2008. We identified 4,261 incident prostate cancer cases, including 563 lethal cases through 2010. Sleep disruption was assessed in 2004 among 19,639 men, with 930 prostate cancer cases (50 lethal) identified from 2004 to 2010. Cox proportional hazards models were used to evaluate the association between sleep insufficiency and risk of overall and lethal prostate cancer.

Results: In 1987, 2% of men reported sleeping ≤5 hours per night. We found no association between habitual sleep duration or change in sleep duration with the risk of advanced or lethal prostate cancer. We also found no association between waking up during the night, difficulty falling asleep, or waking up too early, and risk of prostate cancer. In 2004, 6% of men reported never feeling rested when they woke up; these men had an increased risk of developing lethal prostate cancer compared with those who reported always feeling rested when they woke up (RR, 3.05; 95% CI, 1.15–8.10).

Conclusions: We found no consistent association between self-reported sleep duration or sleep disruption and any of our prostate cancer outcomes.

Impact: We did not find support for a consistent association between self-reported sleep and risk of advanced or lethal prostate cancer in this large cohort of men. Cancer Epidemiol Biomarkers Prev; 25(2); 302–8. ©2015 AACR.
Data from MicroRNA Polymorphisms and Risk of Colorectal Cancer
Authors: Schmit Stephanie L. , Gollub Jeremy , Shapero Michael H. , Huang Shu-Chen , Rennert Hedy S. , Finn Andrea , Rennert Gad , Gruber Stephen B.
Published: April 2023

Abstract
Background: miRNAs act as post-transcriptional regulators of gene expression. Genetic variation in miRNA-encoding sequences or their corresponding binding sites may affect the fidelity of the miRNA–mRNA interaction and subsequently alter the risk of cancer development.

Methods: This study expanded the search for miRNA-related polymorphisms contributing to the etiology of colorectal cancer across the genome using a novel platform, the Axiom miRNA Target Site Genotyping Array (237,858 markers). After quality control, the study included 596 cases and 429 controls from the Molecular Epidemiology of Colorectal Cancer study, a population-based case–control study of colorectal cancer in northern Israel. The association between each marker and colorectal cancer status was examined assuming a log-additive genetic model using logistic regression adjusted for sex, age, and two principal components.

Results: Twenty-three markers had P values less than 5.0E−04, and the most statistically significant association involved rs2985 (chr6:34845648; intronic of UHRF1BP1; OR = 0.66; P = 3.7E−05). Furthermore, this study replicated a previously published risk locus, rs1051690, in the 3′-untranslated region of the insulin receptor gene INSR (OR = 1.38; P = 0.03), with strong evidence of differences in INSR gene expression by genotype.

Conclusions: This study is the first to examine associations between genetic variation in miRNA target sites and colorectal cancer using a genome-wide approach. Functional studies to identify allele-specific effects on miRNA binding are needed to confirm the regulatory capacity of genetic variation to influence risk of colorectal cancer.

Impact: This study demonstrates the potential for an miRNA-targeted genome-wide association study to identify candidate susceptibility loci and prioritize them for functional characterization. Cancer Epidemiol Biomarkers Prev; 24(1); 65–72. ©2014 AACR.
Data from Circulating DNA and Survival in Solid Tumors
Authors: Ocaña Alberto , Díez-González Laura , García-Olmo Dolores C. , Templeton Arnoud J. , Vera-Badillo Francisco , José Escribano María , Serrano-Heras Gemma , Corrales-Sánchez Verónica , Seruga Bostjan , Andrés-Pretel Fernando , Pandiella Atanasio , Amir Eitan
Published: April 2023

Abstract
Background: The ability to undertake molecular analysis to inform on prognosis and predictors of response to therapy is limited by accessibility of tissue. Measurement of total circulating free DNA (cfDNA) or circulating tumor DNA (ctDNA) in peripheral blood may allow easier access to tumor material and help to predict clinical outcomes.

Methods: A systematic review of electronic databases identified publications exploring the association between cfDNA or ctDNA and overall survival (OS) in solid tumors. HRs for OS were extracted from multivariable analyses and included in a meta-analysis. Pooled HRs were computed and weighted using generic inverse variance and random-effect modeling. For studies not reporting multivariable analyses, univariable ORs were estimated from Kaplan–Meier curves for OS at 1 and 3 years.

Results: Thirty-nine studies comprising 4,052 patients were included in the analysis. Detection of ctDNA was associated with a significantly worse OS in multivariable analyses [HR, 2.70; 95% confidence interval (CI), 2.02–3.61; P < 0.001). Similar results were observed in the univariable analyses at 3 and 1 year (OR, 4.83; 95% CI, 3.20–7.28; P < 0.001).There was also a statistically significant association between high total cfDNA and worse OS for studies reporting multivariable and univariate data at 3 years (HR, 1.91; 95% CI, 1.59–2.29; P < 0.001 and OR, 2.82; 95% CI, 1.93–4.13; P < 0.001, respectively).

Conclusions: High levels of total cfDNA and presence of ctDNA are associated with worse survival in solid tumors.

Impact: Circulating DNA is associated with worse outcome in solid tumors. Cancer Epidemiol Biomarkers Prev; 25(2); 399–406. ©2015 AACR.
Data from Quantification of Circulating miRNAs by Droplet Digital PCR: Comparison of EvaGreen- and TaqMan-Based Chemistries
Authors: Miotto Elena , Saccenti Elena , Lupini Laura , Callegari Elisa , Negrini Massimo , Ferracin Manuela
Published: April 2023

Abstract
Droplet digital PCR (ddPCR) has been successfully used with TaqMan assays to assess gene expression through the quantification of mRNA and miRNA. Recently, a new ddPCR system that can also run DNA-binding dye-based assays has been developed but it has not yet been tested for miRNA. We tested and compared the feasibility of quantifying miRNA with the new QX200 Droplet Digital PCR system when used with EvaGreen dye– and TaqMan probe–based assays. RNA from plasma and serum of 28 patients with cancer and healthy persons was reverse-transcribed and quantified for two circulating miRNAs and one added exogenous miRNA, with both EvaGreen dye–based miRCURY LNA miRNA assays and TaqMan assays. Amplification and detection of target miRNAs were performed on the QX200 ddPCR system. Conditions required to run miRCURY LNA miRNA assays were optimized. The EvaGreen-based assay was precise, reproducible over a range of concentrations of four orders of magnitude, and sensitive, detecting a target miRNA at levels down to 1 copy/μL. When this assay was compared with TaqMan assays, high concordance was obtained for two endogenous miRNAs in serum and plasma (Pearson r > 0.90). EvaGreen dye–based and TaqMan probe–based assays can be equally used with the ddPCR system to quantify circulating miRNAs in human plasma and serum. This study establishes the basis for using EvaGreen dye–based assays on a ddPCR system for quantifying circulating miRNA biomarkers and potentially other low-abundance RNA biomarkers in human biofluids.

See all the articles in this CEBP Focus section, “Biomarkers, Biospecimens, and New Technologies in Molecular Epidemiology.”

Cancer Epidemiol Biomarkers Prev; 23(12); 2638–42. ©2014 AACR.
Data from Variants in 6q25.1 Are Associated with Mammographic Density in Malaysian Chinese Women
Authors: Mariapun Shivaani , Ho Weang Kee , Kang Peter Choon Eng , Li Jingmei , Lindström Sara , Yip Cheng Har , Teo Soo Hwang
Published: April 2023

Abstract
Background: Mammographic density is an established risk factor for breast cancer and has a strong heritable component. Genome-wide association studies (GWAS) for mammographic density conducted in women of European descent have identified several genetic associations, but none of the studies have been tested in Asians. We sought to investigate whether these genetic loci, and loci associated with breast cancer risk and breast size, are associated with mammographic density in an Asian cohort.

Methods: We conducted genotyping by mass spectrometry in 1,189 women (865 Chinese, 187 Indian, and 137 Malay). Quantitative measurements of mammographic density were performed using ImageJ, a fully automated thresholding technique. The associations of SNPs to densities were analyzed using linear regression models.

Results: We successfully evaluated the associations of 36 SNPs with mammographic densities. After adjusting for age, body mass index, parity, and menopausal status, we found that in our cohort of 865 Malaysian Chinese, three SNPs in the 6q25.1 region near ESR1 (rs2046210, rs12173570, and rs10484919) that were associated with mammographic density, breast cancer risk, or breast size in previous GWAS were significantly associated with both percentage density and absolute dense area. We could not replicate the most significant association found previously in European women (rs10995190, ZNF365 gene) because the minor allele was absent for Asian women.

Conclusion: We found that the directions of genetic associations were similar to those reported in Caucasian women.

Impact: Our results show that even in Asian women with lower population risk to breast cancer, there is shared heritability between mammographic density and breast cancer risk. Cancer Epidemiol Biomarkers Prev; 25(2); 327–33. ©2015 AACR.
Data from Global Cancer in Women: Burden and Trends
Authors: Torre Lindsey A. , Islami Farhad , Siegel Rebecca L. , Ward Elizabeth M. , Jemal Ahmedin
Published: April 2023

Abstract
This review is an abbreviated version of a report prepared for the American Cancer Society Global Health department and EMD Serono, Inc., a subsidiary of Merck KGaA, Darmstadt, Germany, which was released at the Union for International Cancer Control World Cancer Congress in Paris in November 2016. The original report can be found at https://www.cancer.org/health-care-professionals/our-global-health-work/global-cancer-burden/global-burden-of-cancer-in-women.html. Staff in the Intramural Research Department of the American Cancer Society designed and conducted the study, including analysis, interpretation, and presentation of the review. The funding sources had no involvement in the study design, data analysis and interpretation, or preparation of the review.

There are striking disparities in the global cancer burden in women, yet few publications highlight cancer occurrence in this population, particularly for cancers that are not sex specific. This article, the first in a series of two, summarizes the current burden, trends, risk factors, prevention, early detection, and survivorship of all cancers combined and seven sites (breast, cervix, uterine corpus, ovary, colorectum, lung, and liver) that account for about 60% of the cancer burden among women worldwide, using data from the International Agency for Research on Cancer. Estimated 2012 overall cancer death rates in general are higher among women in low- and middle-income countries (LMICs) than high-income countries (HICs), despite their lower overall incidence rates, largely due to inadequate access to early detection and treatment. For example, the top mortality rates are in Zimbabwe (147 deaths per 100,000) and Malawi (138). Furthermore, incidence rates of cancers associated with economic development (e.g., lung, breast, colorectum) are rising in several LMICs. The burden of cancer among women could be substantially reduced in both HICs and LMICs through broad and equitable implementation of effective interventions, including tobacco control, HPV and HBV vaccination, and screening (breast, cervix, and colorectum). Cancer Epidemiol Biomarkers Prev; 26(4); 444–57. ©2017 AACR.

See related article by Islami et al. in this CEBP Focus section, “Global Cancer in Women.”
Data from Do Men and Women Need to Be Screened Differently with Fecal Immunochemical Testing? A Cost-Effectiveness Analysis
Authors: Meulen Miriam P. van der , Kapidzic Atija , Leerdam Monique E. van , van der Steen Alex , Kuipers Ernst J. , Spaander Manon C.W. , de Koning Harry J. , Hol Lieke , Lansdorp-Vogelaar Iris
Published: April 2023

Abstract
Background: Several studies suggest that test characteristics for the fecal immunochemical test (FIT) differ by gender, triggering a debate on whether men and women should be screened differently. We used the microsimulation model MISCAN-Colon to evaluate whether screening stratified by gender is cost-effective.

Methods: We estimated gender-specific FIT characteristics based on first-round positivity and detection rates observed in a FIT screening pilot (CORERO-1). Subsequently, we used the model to estimate harms, benefits, and costs of 480 gender-specific FIT screening strategies and compared them with uniform screening.

Results: Biennial FIT screening from ages 50 to 75 was less effective in women than men [35.7 vs. 49.0 quality-adjusted life years (QALY) gained, respectively] at higher costs (€42,161 vs. −€5,471, respectively). However, the incremental QALYs gained and costs of annual screening compared with biennial screening were more similar for both genders (8.7 QALYs gained and €26,394 for women vs. 6.7 QALYs gained and €20,863 for men). Considering all evaluated screening strategies, optimal gender-based screening yielded at most 7% more QALYs gained than optimal uniform screening and even resulted in equal costs and QALYs gained from a willingness-to-pay threshold of €1,300.

Conclusions: FIT screening is less effective in women, but the incremental cost-effectiveness is similar in men and women. Consequently, screening stratified by gender is not more cost-effective than uniform FIT screening.

Impact: Our conclusions support the current policy of uniform FIT screening. Cancer Epidemiol Biomarkers Prev; 26(8); 1328–36. ©2017 AACR.
Data from Comparison of Triage Strategies for HPV-Positive Women: Canadian Cervical Cancer Screening Trial Results
Authors: Isidean Sandra D. , Mayrand Marie-Hélène , Ramanakumar Agnihotram V. , Rodrigues Isabel , Ferenczy Alex , Ratnam Sam , Coutlée François , Franco Eduardo L.
Published: April 2023

Abstract
Background: High-risk human papillomavirus (HR-HPV) testing has become a preferred cervical cancer screening strategy in some countries due to its superior sensitivity over cytology-based methods for identifying cervical intraepithelial neoplasia of grade 2 or worse (CIN2+). Improved sensitivity has been accompanied by reductions in specificity and concerns regarding overscreening and overtreatment of women with transient or nonprogressing HR-HPV infections. Triage of HR-HPV+ women to colposcopy is, thus, warranted for appropriate management and treatment.

Methods: Using data from the Canadian Cervical Cancer Screening Trial (CCCaST), we compared the performance of cytology and HR-HPV strategies to detect CIN2+ among HR-HPV+ women (age, 30–69 years). Colposcopy referral rates and performance gains from adding other HR-HPV genotypes to HPV16/18+ triage were also evaluated.

Results: A strategy referring all women HPV16/18+ and HPV16/18−, but with atypical squamous cells of undetermined significance or worse cytology (ASC-US+) had the highest sensitivity [82.5%; 95% confidence interval (CI), 70.9%–91.0%] but yielded the highest colposcopy referral rate. HPV16/18+ triage was the next most sensitive strategy (64.1%; 95% CI, 51.1%–75.7%). Low-grade squamous intraepithelial lesion or worse cytology (LSIL+) triage yielded a low sensitivity (32.8%; 95% CI, 21.9%–45.4%) but had the most favorable specificity (93.6%; 95% CI, 91.0%–95.6%), positive predictive value (41.5%; 95% CI, 28.1%–55.9%), and colposcopy referral rate of strategies examined. HPV viral load triage strategies did not perform optimally overall. Inclusion of HR-HPV genotypes 31 and 52 to HPV16/18+ triage provided the highest sensitivities.

Conclusion: Concerns surrounding HPV-based screening can be effectively mitigated via triage.

Impact: Balancing the benefits of HPV-based primary cervical screening with informed management recommendations for HR-HPV+ women may decide the success of its widening utilization. Cancer Epidemiol Biomarkers Prev; 26(6); 923–9. ©2017 AACR.
Supplementary Data from Induction of Noxa Sensitizes Human Colorectal Cancer Cells Expressing Mcl-1 to the Small-Molecule Bcl-2/Bcl-xL Inhibitor, ABT-737
Authors: Okumura Kenji , Huang Shengbing , Sinicrope Frank A.
Published: April 2023

Supplementary Data from Induction of Noxa Sensitizes Human Colorectal Cancer Cells Expressing Mcl-1 to the Small-Molecule Bcl-2/Bcl-xL Inhibitor, ABT-737
Related Article from Photodynamic Therapy: A Light in the Darkness?
Authors: Lin Alexander , Hahn Stephen M.
Published: April 2023

Related Article from Photodynamic Therapy: A Light in the Darkness?
Supplementary Data from Intratumoral Expression of Mature Human Neutrophil Peptide-1 Mediates Antitumor Immunity in Mice
Authors: Wang Yong-sheng , Li Dan , Shi Hua-shan , Wen Yan-jun , Yang Li , Xu Ning , Chen Xian-cheng , Chen Xiang , Chen Ping , Li Jiong , Deng Hong-xin , Wang Chun-ting , Xie Gang , Huang Shan , Mao Yong-qiu , Chen Li-juan , Zhao Xia , Wei Yu-quan
Published: April 2023

Supplementary Data from Intratumoral Expression of Mature Human Neutrophil Peptide-1 Mediates Antitumor Immunity in Mice
Supplementary Movie S3 from Development and Characterization of a Novel In vivo Model of Carcinoid Syndrome
Authors: Jackson Lindsey N. , Chen L. Andy , Larson Shawn D. , Silva Scott R. , Rychahou Piotr G. , Boor Paul J. , Li Jing , DeFreitas Gilberto , Stafford W. Lane , Townsend Courtney M. , Evers B. Mark
Published: April 2023

Supplementary Movie S3 from Development and Characterization of a Novel In vivo Model of Carcinoid Syndrome
Related Article from Palettes of Vaccines and Immunostimulatory Monoclonal Antibodies for Combination
Authors: Melero Ignacio , Martinez-Forero Ivan , Dubrot Juan , Suarez Natalia , Palazón Asis , Chen Lieping
Published: April 2023

Related Article from Palettes of Vaccines and Immunostimulatory Monoclonal Antibodies for Combination
Supplementary Data from Circulating Levels of Soluble KIT Serve as a Biomarker for Clinical Outcome in Gastrointestinal Stromal Tumor Patients Receiving Sunitinib following Imatinib Failure
Authors: DePrimo Samuel E. , Huang Xin , Blackstein Martin E. , Garrett Christopher R. , Harmon Charles S. , Schöffski Patrick , Shah Manisha H. , Verweij Jaap , Baum Charles M. , Demetri George D.
Published: April 2023

Supplementary Data from Circulating Levels of Soluble KIT Serve as a Biomarker for Clinical Outcome in Gastrointestinal Stromal Tumor Patients Receiving Sunitinib following Imatinib Failure
Supplementary Data from Expression of p21 Protein Predicts Clinical Outcome in DLBCL Patients Older than 60 Years Treated with R-CHOP but not CHOP: A Prospective ECOG and Southwest Oncology Group Correlative Study on E4494
Authors: Winter Jane N. , Li Shuli , Aurora Vikas , Variakojis Daina , Nelson Beverly , Krajewska Maryla , Zhang Lijun , Habermann Thomas M. , Fisher Richard I. , Macon William R. , Chhanabhai Mukesh , Felgar Raymond E. , Hsi Eric D. , Medeiros L. Jeffrey , Weick James K. , Weller Edie A. , Melnick Ari , Reed John C. , Horning Sandra J. , Gascoyne Randy D.
Published: April 2023

Supplementary Data from Expression of p21 Protein Predicts Clinical Outcome in DLBCL Patients Older than 60 Years Treated with R-CHOP but not CHOP: A Prospective ECOG and Southwest Oncology Group Correlative Study on E4494
Supplementary Data from Induction of Bim Expression Contributes to the Antitumor Synergy Between Sorafenib and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Inhibitor CI-1040 in Hepatocellular Carcinoma
Authors: Ou Da-Liang , Shen Ying-Chun , Liang Ja-Der , Liou Jun-Yang , Yu Sung-Liang , Fan Hsiang-Hsuan , Wang Da-Sheng , Lu Yen-Shen , Hsu Chiun , Cheng Ann-Lii
Published: April 2023

Supplementary Data from Induction of Bim Expression Contributes to the Antitumor Synergy Between Sorafenib and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Inhibitor CI-1040 in Hepatocellular Carcinoma
Supplementary Data from Marked Activity of Irinotecan and Rapamycin Combination toward Colon Cancer Cells In vivo and In vitro Is Mediated through Cooperative Modulation of the Mammalian Target of Rapamycin/Hypoxia-Inducible Factor-1α Axis
Authors: Pencreach Erwan , Guérin Eric , Nicolet Céline , Lelong-Rebel Isabelle , Voegeli Anne-Claire , Oudet Pierre , Larsen Annette K. , Gaub Marie-Pierre , Guenot Dominique
Published: April 2023

Supplementary Data from Marked Activity of Irinotecan and Rapamycin Combination toward Colon Cancer Cells In vivo and In vitro Is Mediated through Cooperative Modulation of the Mammalian Target of Rapamycin/Hypoxia-Inducible Factor-1α Axis
CCR Translation for the Article from Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes
Authors: Huang Yi , Stewart Tracy Murray , Wu Yu , Baylin Stephen B. , Marton Laurence J. , Perkins Brandy , Jones Richard J. , Woster Patrick M. , Casero Robert A.
Published: April 2023

CCR Translation for the Article from Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes
Supplementary Figure 5 from Metabolic Imaging: A Link between Lactate Dehydrogenase A, Lactate, and Tumor Phenotype
Authors: Serganova Inna , Rizwan Asif , Ni Xiaohui , Thakur Sunitha B. , Vider Jelena , Russell James , Blasberg Ronald , Koutcher Jason A.
Published: April 2023

PDF file - 326K
Supplementary Figure 1 from Species D Adenoviruses as Oncolytics against B-cell Cancers
Authors: Chen Christopher Y. , Senac Julien S. , Weaver Eric A. , May Shannon M. , Jelinek Diane F. , Greipp Philip , Witzig Thomas , Barry Michael A.
Published: April 2023

PDF file - 884KB
Supplementary Figure 2 from Metabolic Imaging: A Link between Lactate Dehydrogenase A, Lactate, and Tumor Phenotype
Authors: Serganova Inna , Rizwan Asif , Ni Xiaohui , Thakur Sunitha B. , Vider Jelena , Russell James , Blasberg Ronald , Koutcher Jason A.
Published: April 2023

PDF file - 192K
Supplementary Figure 2 from Metadherin Promotes Hepatocellular Carcinoma Metastasis through Induction of Epithelial–Mesenchymal Transition
Authors: Zhu Kai , Dai Zhi , Pan Qi , Wang Zheng , Yang Guo-Huan , Yu Lei , Ding Zhen-Bin , Shi Guo-Ming , Ke Ai-Wu , Yang Xin-Rong , Tao Zhong-Hua , Zhao Yi-Ming , Qin Yi , Zeng Hai-Ying , Tang Zhao-You , Fan Jia , Zhou Jian
Published: April 2023

PDF file - 2.5MB
Supplementary Figure 1 from Enhancement of 5-Fluorouracil-induced In Vitro and In Vivo Radiosensitization with MEK Inhibition
Authors: Urick Mary Ellen , Chung Eun Joo , Shield William P. , Gerber Naamit , White Ayla , Sowers Anastasia , Thetford Angela , Camphausen Kevin , Mitchell James , Citrin Deborah E.
Published: April 2023

PDF file - 69K
Supplementary Data 3 from Serum Autoantibody Signature of Ductal Carcinoma In Situ Progression to Invasive Breast Cancer
Authors: Mangé Alain , Lacombe Jérôme , Bascoul-Mollevi Caroline , Jarlier Marta , Lamy Pierre-Jean , Rouanet Philippe , Maudelonde Thierry , Solassol Jérôme
Published: April 2023

PDF file - 112K
Supplementary Data 2 from Serum Autoantibody Signature of Ductal Carcinoma In Situ Progression to Invasive Breast Cancer
Authors: Mangé Alain , Lacombe Jérôme , Bascoul-Mollevi Caroline , Jarlier Marta , Lamy Pierre-Jean , Rouanet Philippe , Maudelonde Thierry , Solassol Jérôme
Published: April 2023

PDF file - 93K
Supplementary Figure Legend from High XRCC1 Protein Expression Is Associated with Poorer Survival in Patients with Head and Neck Squamous Cell Carcinoma
Authors: Ang Mei-Kim , Patel Mihir R. , Yin Xiao-Ying , Sundaram Sneha , Fritchie Karen , Zhao Ni , Liu Yufeng , Freemerman Alex J. , Wilkerson Matthew D. , Walter Vonn , Weissler Mark C. , Shockley William W. , Couch Marion E. , Zanation Adam M. , Hackman Trevor , Chera Bhishamjit S. , Harris Stephen L. , Miller C. Ryan , Thorne Leigh B. , Hayward Michele C. , Funkhouser William K. , Olshan Andrew F. , Shores Carol G. , Makowski Liza , Hayes D. Neil
Published: April 2023

PDF file - 73KB
Supplementary Figure 1 from High XRCC1 Protein Expression Is Associated with Poorer Survival in Patients with Head and Neck Squamous Cell Carcinoma
Authors: Ang Mei-Kim , Patel Mihir R. , Yin Xiao-Ying , Sundaram Sneha , Fritchie Karen , Zhao Ni , Liu Yufeng , Freemerman Alex J. , Wilkerson Matthew D. , Walter Vonn , Weissler Mark C. , Shockley William W. , Couch Marion E. , Zanation Adam M. , Hackman Trevor , Chera Bhishamjit S. , Harris Stephen L. , Miller C. Ryan , Thorne Leigh B. , Hayward Michele C. , Funkhouser William K. , Olshan Andrew F. , Shores Carol G. , Makowski Liza , Hayes D. Neil
Published: April 2023

PDF file - 157KB
Supplementary Figure 5 from Disruptive TP53 Mutation Is Associated with Aggressive Disease Characteristics in an Orthotopic Murine Model of Oral Tongue Cancer
Authors: Sano Daisuke , Xie Tong-Xin , Ow Thomas J. , Zhao Mei , Pickering Curtis R. , Zhou Ge , Sandulache Vlad C. , Wheeler David A. , Gibbs Richard A. , Caulin Carlos , Myers Jeffrey N.
Published: April 2023

PDf file - 279K
Supplementary Figure 3 from Disruptive TP53 Mutation Is Associated with Aggressive Disease Characteristics in an Orthotopic Murine Model of Oral Tongue Cancer
Authors: Sano Daisuke , Xie Tong-Xin , Ow Thomas J. , Zhao Mei , Pickering Curtis R. , Zhou Ge , Sandulache Vlad C. , Wheeler David A. , Gibbs Richard A. , Caulin Carlos , Myers Jeffrey N.
Published: April 2023

PDf file - 156K
Supplementary Table 2 from Copy Number Gain of 1q25 Predicts Poor Progression-Free Survival for Pediatric Intracranial Ependymomas and Enables Patient Risk Stratification: A Prospective European Clinical Trial Cohort Analysis on Behalf of the Children's Cancer Leukaemia Group (CCLG), Société Française d'Oncologie Pédiatrique (SFOP), and International Society for Pediatric Oncology (SIOP)
Authors: Kilday John-Paul , Mitra Biswaroop , Domerg Caroline , Ward Jennifer , Andreiuolo Felipe , Osteso-Ibanez Teresa , Mauguen Audrey , Varlet Pascale , Le Deley Marie-Cecile , Lowe James , Ellison David W. , Gilbertson Richard J. , Coyle Beth , Grill Jacques , Grundy Richard G.
Published: April 2023

PDF file - 68K, Pooled analysis of prognostic factors for overall survival stratified on treatment cohort for 147 iFISH evaluable patients. Shows a pooled analysis of prognostic factors for overall survival stratified on treatment cohort for 147 iFISH evaluable patients.
Supplementary Table 1 from Copy Number Gain of 1q25 Predicts Poor Progression-Free Survival for Pediatric Intracranial Ependymomas and Enables Patient Risk Stratification: A Prospective European Clinical Trial Cohort Analysis on Behalf of the Children's Cancer Leukaemia Group (CCLG), Société Française d'Oncologie Pédiatrique (SFOP), and International Society for Pediatric Oncology (SIOP)
Authors: Kilday John-Paul , Mitra Biswaroop , Domerg Caroline , Ward Jennifer , Andreiuolo Felipe , Osteso-Ibanez Teresa , Mauguen Audrey , Varlet Pascale , Le Deley Marie-Cecile , Lowe James , Ellison David W. , Gilbertson Richard J. , Coyle Beth , Grill Jacques , Grundy Richard G.
Published: April 2023

PDF file - 77K, Clinicopathological data and chromosome arm imbalance results for the SNP array cohort. Shows clinicopathological data and chromosome arm imbalance results for the SNP array cohort.
Supplementary Table 1 from A Small-Molecule Inhibitor Targeting the Mitotic Spindle Checkpoint Impairs the Growth of Uterine Leiomyosarcoma
Authors: Shan Weiwei , Akinfenwa Patricia Y. , Savannah Kari B. , Kolomeyevskaya Nonna , Laucirica Rudolfo , Thomas Dafydd G. , Odunsi Kunle , Creighton Chad J. , Lev Dina C. , Anderson Matthew L.
Published: April 2023

PDF file, 673KB, Impact of MK-5108 on the IC50 of gemcitabine or docetaxel in ULMS cell lines.
Supplementary Figure 5 from Overexpression of GOLPH3 Promotes Proliferation and Tumorigenicity in Breast Cancer via Suppression of the FOXO1 Transcription Factor
Authors: Zeng Zhaolei , Lin Huanxin , Zhao Xiaohui , Liu Guanglin , Wang Xi , Xu Ruihua , Chen Kun , Li Jun , Song Libing
Published: April 2023

PDF file - 159K, IHC analysis of GOLPH3, Ki67 and cyclin D1 expression and H&E staining in tumor xenograft tissues
Supplementary Figure 2 from Overexpression of GOLPH3 Promotes Proliferation and Tumorigenicity in Breast Cancer via Suppression of the FOXO1 Transcription Factor
Authors: Zeng Zhaolei , Lin Huanxin , Zhao Xiaohui , Liu Guanglin , Wang Xi , Xu Ruihua , Chen Kun , Li Jun , Song Libing
Published: April 2023

PDF file - 95K, IHC analysis of GOLPH3 expression in normal breast tissues and breast cancer tissues with different degrees of differentiation
Supplementary Figure 1 from Overexpression of GOLPH3 Promotes Proliferation and Tumorigenicity in Breast Cancer via Suppression of the FOXO1 Transcription Factor
Authors: Zeng Zhaolei , Lin Huanxin , Zhao Xiaohui , Liu Guanglin , Wang Xi , Xu Ruihua , Chen Kun , Li Jun , Song Libing
Published: April 2023

PDF file - 45K, GOLPH3 expression is upregulated in breast cancer
Supplementary Figure 1, Tables 1-7 from Resection of Non–Small Cell Lung Cancers Reverses Tumor-Induced Gene Expression Changes in the Peripheral Immune System
Authors: Kossenkov Andrew V. , Vachani Anil , Chang Celia , Nichols Calen , Billouin Shere , Horng Wenhwai , Rom William N. , Albelda Steven M. , Showe Michael K. , Showe Louise C.
Published: April 2023

PDF file - 153K
Supplementary Table 1 from Prognostic Immune Markers in Non–Small Cell Lung Cancer
Authors: Suzuki Kei , Kachala Stefan S. , Kadota Kyuichi , Shen Ronglai , Mo Qianxing , Beer David G. , Rusch Valerie W. , Travis William D. , Adusumilli Prasad S.
Published: April 2023

Supplementary Table 1 from Prognostic Immune Markers in Non–Small Cell Lung Cancer
Supplementary Table 1 from Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma
Authors: Turley Ryan S. , Fontanella Andrew N. , Padussis James C. , Toshimitsu Hiroaki , Tokuhisa Yoshihiro , Cho Eugenia H. , Hanna Gabi , Beasley Georgia M. , Augustine Christina K. , Dewhirst Mark W. , Tyler Douglas S.
Published: April 2023

PDF file, 55KB, Summary of tumor response to systemic bevacizumab and regional melphalan.
Supplementary Figure 2 from Bevacizumab-Induced Alterations in Vascular Permeability and Drug Delivery: A Novel Approach to Augment Regional Chemotherapy for In-Transit Melanoma
Authors: Turley Ryan S. , Fontanella Andrew N. , Padussis James C. , Toshimitsu Hiroaki , Tokuhisa Yoshihiro , Cho Eugenia H. , Hanna Gabi , Beasley Georgia M. , Augustine Christina K. , Dewhirst Mark W. , Tyler Douglas S.
Published: April 2023

PDF file, 71KB, Bevacizumab does not alter in vitro LPAM chemosensitivity.
Supplementary Table 1 from Aflibercept (VEGF Trap) in Inoperable Stage III or Stage IV Melanoma of Cutaneous or Uveal Origin
Authors: Tarhini Ahmad A. , Frankel Paul , Margolin Kim A. , Christensen Scott , Ruel Christopher , Shipe-Spotloe Janice , Gandara David R. , Chen Alice , Kirkwood John M.
Published: April 2023

PDF file - 16K
Supplementary Table 1 from PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients
Authors: Lotan Tamara L. , Gurel Bora , Sutcliffe Siobhan , Esopi David , Liu Wennuan , Xu Jianfeng , Hicks Jessica L. , Park Ben H. , Humphreys Elizabeth , Partin Alan W. , Han Misop , Netto George J. , Isaacs William B. , De Marzo Angelo M.
Published: April 2023

PDF file - 69KB, Correlation of PTEN protein status by immunohistochemistry (IHC) with PTEN genomic status by sequencing in NCI-60 cell line panel.
CCR Translation for This Article from Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth
Authors: Nagaraj Nagathihalli S. , Washington M. Kay , Merchant Nipun B.
Published: April 2023

CCR Translation for This Article from Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth
Supplementary Figure Legend 1 from ON 01910.Na Is Selectively Cytotoxic for Chronic Lymphocytic Leukemia Cells through a Dual Mechanism of Action Involving PI3K/AKT Inhibition and Induction of Oxidative Stress
Authors: Chapman Colby M. , Sun Xiameng , Roschewski Mark , Aue Georg , Farooqui Mohamed , Stennett Lawrence , Gibellini Federica , Arthur Diane , Pérez-Galán Patricia , Wiestner Adrian
Published: April 2023

PDF file - 44K
Related Article from Increasing Potential of HER3 Signaling in Colon Cancer Progression and Therapy
Authors: Gespach Christian
Published: April 2023

Related Article from Increasing Potential of HER3 Signaling in Colon Cancer Progression and Therapy
Supplementary Data from A 4-Gene Signature Associated with Clinical Outcome in High-Grade Gliomas
Authors: de Tayrac Marie , Aubry Marc , Saïkali Stephan , Etcheverry Amandine , Surbled Cyrille , Guénot Frédérique , Galibert Marie-Dominique , Hamlat Abderrahmane , Lesimple Thierry , Quillien Véronique , Menei Philippe , Mosser Jean
Published: April 2023

Supplementary Figures S1-S9; Supplementary Tables S1-S5.