bluuebunny/crossref_metadata_2025 huggingface dataset:
MLink: Linking Black-Box Models for Collaborative Multi-Model Inference
Authors: Yuan Mu , Zhang Lan , Li Xiang-Yang
Published: July 2022

The cost efficiency of model inference is critical to real-world machine learning (ML) applications, especially for delay-sensitive tasks and resource-limited devices. A typical dilemma is: in order to provide complex intelligent services (e.g. smart city), we need inference results of multiple ML models, but the cost budget (e.g. GPU memory) is not enough to run all of them. In this work, we study underlying relationships among black-box ML models and propose a novel learning task: model linking. Model linking aims to bridge the knowledge of different black-box models by learning mappings (dubbed model links) between their output spaces. Based on model links, we developed a scheduling algorithm, named MLink. Through collaborative multi-model inference enabled by model links, MLink can improve the accuracy of obtained inference results under the cost budget. We evaluated MLink on a multi-modal dataset with seven different ML models and two real-world video analytics systems with six ML models and 3,264 hours of video. Experimental results show that our proposed model links can be effectively built among various black-box models. Under the budget of GPU memory, MLink can save 66.7% inference computations while preserving 94% inference accuracy, which outperforms multi-task learning, deep reinforcement learning-based scheduler and frame filtering baselines.
Enhancing Column Generation by a Machine-Learning-Based Pricing Heuristic for Graph Coloring
Authors: Shen Yunzhuang , Sun Yuan , Li Xiaodong , Eberhard Andrew , Ernst Andreas
Published: July 2022

Column Generation (CG) is an effective method for solving large-scale optimization problems. CG starts by solving a subproblem with a subset of columns (i.e., variables) and gradually includes new columns that can improve the solution of the current subproblem. The new columns are generated as needed by repeatedly solving a pricing problem, which is often NP-hard and is a bottleneck of the CG approach. To tackle this, we propose a Machine-Learning-based Pricing Heuristic (MLPH) that can generate many high-quality columns efficiently. In each iteration of CG, our MLPH leverages an ML model to predict the optimal solution of the pricing problem, which is then used to guide a sampling method to efficiently generate multiple high-quality columns. Using the graph coloring problem, we empirically show that MLPH significantly enhances CG as compared to six state-of-the-art methods, and the improvement in CG can lead to substantially better performance of the branch-and-price exact method.
Bi-CMR: Bidirectional Reinforcement Guided Hashing for Effective Cross-Modal Retrieval
Authors: Li Tieying , Yang Xiaochun , Wang Bin , Xi Chong , Zheng Hanzhong , Zhou Xiangmin
Published: July 2022

Cross-modal hashing has attracted considerable attention for large-scale multimodal data. Recent supervised cross-modal hashing methods using multi-label networks utilize the semantics of multi-labels to enhance retrieval accuracy, where label hash codes are learned independently. However, all these methods assume that label annotations reliably reflect the relevance between their corresponding instances, which is not true in real applications. In this paper, we propose a novel framework called Bidirectional Reinforcement Guided Hashing for Effective Cross-Modal Retrieval (Bi-CMR), which exploits a bidirectional learning to relieve the negative impact of this assumption. Specifically, in the forward learning procedure, we highlight the representative labels and learn the reinforced multi-label hash codes by intra-modal semantic information, and further adjust similarity matrix. In the backward learning procedure, the reinforced multi-label hash codes and adjusted similarity matrix are used to guide the matching of instances. We construct two datasets with explicit relevance labels that reflect the semantic relevance of instance pairs based on two benchmark datasets. The Bi-CMR is evaluated by conducting extensive experiments over these two datasets. Experimental results prove the superiority of Bi-CMR over four state-of-the-art methods in terms of effectiveness.
A First Mathematical Runtime Analysis of the Non-dominated Sorting Genetic Algorithm II (NSGA-II)
Authors: Zheng Weijie , Liu Yufei , Doerr Benjamin
Published: July 2022

The non-dominated sorting genetic algorithm II (NSGA-II) is the most intensively used multi-objective evolutionary algorithm (MOEA) in real-world applications. However, in contrast to several simple MOEAs analyzed also via mathematical means, no such study exists for the NSGA-II so far. In this work, we show that mathematical runtime analyses are feasible also for the NSGA-II. As particular results, we prove that with a population size larger than the Pareto front size by a constant factor, the NSGA-II with two classic mutation operators and three different ways to select the parents satisfies the same asymptotic runtime guarantees as the SEMO and GSEMO algorithms on the basic OneMinMax and LOTZ benchmark functions. However, if the population size is only equal to the size of the Pareto front, then the NSGA-II cannot efficiently compute the full Pareto front (for an exponential number of iterations, the population will always miss a constant fraction of the Pareto front). Our experiments confirm the above findings.
Constitutive modelling of non-cohesive soils under high-strain rates: a consistency approach
Authors: Zambrano-Cruzatty Luis E. , Yerro Alba , Macedo Jorge
Published: July 2022

Rapid loading of sands is a common issue in geotechnical engineering problems such as projectile or free-fall impact. At high strain rates (HSR), soils show more strength and enhanced dilation (viscoplastic behaviour) compared to the response at low rates (inviscid behaviour). However, few constitutive models account for the viscoplasticity of sands. Hence, the development of viscoplastic models is highly desired. Usually, viscoplasticity is modelled using overstress methods. However, overstress methods impose an overall modification of the constitutive equations, which prevents control of the evolution of internal state variables and the enforcement of the consistency condition. In this study, a generalised consistency–viscoplasticity method is proposed and applied to a non-associative modified Mohr–Coulomb model with coupled stress–dilation relation. The influence of strain rate is incorporated using a work–energy approach by way of an inertial coefficient. Two explicit integration strategies are proposed and compared, and guidelines for their implementation are shared. The numerical response of the model is tested by using drained triaxial simulations under constant axial strain rate, relaxation and impact loading. The results indicate that the consistency–viscoplasticity is a feasible alternative to simulate soil behaviour under HSR, capturing reasonably well the observed experimental responses.
Adaptation of The Academic Resilience Scale (ARS-30): Turkish Version Validity and Reliability Study
Authors: CENGİZ Serkan , PEKER Adem
Published: July 2022

The present study aims to adapt the “Academic Resilience Scale-30” (ARS-30) into Turkish and examine its validity and reliability. The Ars-30 consists of a three-factor structure: perseverance, reflective and adaptive help-seeking, negative affectivity, and emotional response. The study sample consisted of 687 students. As a result of the CFA analysis, it was determined that the scale was in good agreement with the three-factor structure determined in its original form. Similar scale validity analyzes of the scale were made with the general self-efficacy scale and significant positive relationships were determined between both scales. The overall reliability Cronbach Alpha coefficient of the ARS-30 is.89; The Cronbach’s alpha coefficients of the ARS-30 subscales varied from .71 to .85, thus indicating an acceptable level. As a result, it can be said that ARS-30 is a valid and reliable measurement tool for university students in Turkey.
Awe Therapy: Fundamentals, Formulation and Usage Area
Authors: TANHAN Fuat , DENİZ Mehmet Engin , AKGÜN Gülşah Ezgican
Published: July 2022

Human life is in danger of losing the ties with humanity and spirituality as a result of massive dependency on digitalization, modern life and advancements. A potential solution is the cultivation of awe feeling in the field of psychology, which is an emotional perception of wonder and admiration, i.e., witnessing a massive view such as Grand Canyon, a sky full with hundreds of stars or undergoing a mystical experience. In this study, first the literature was meticulously scanned and the researches on awe were compiled within the framework of what this feeling is, its formulation, philosophy. Then, awe's usage areas in Existential and Transpersonal psychology are given, and in addition, therapy suggestions that can strengthen this feeling in patients are also presented. Consequently we believe that awe should be used more in therapies for the elevation of public health and life satisfaction.
The Relationship Between Emotional Autonomy, Functions of Identity and Career Adaptability in Psychological Counselor Candidates: The Mediating Role of Career Decision-Making Self-Efficacy
Authors: AKINCI Funda Nur , ERYILMAZ Ali
Published: July 2022

In this study, the mediating role of career decision-making self-efficacy in the relationship between career adaptability and emotional autonomy and functions of identity psychological counselor candidates who are students of psychological counseling and guidance undergraduate program at the university was examined. The sample of the research consists of 384 psychological counselor candidates studying at state universities. In the study, "Career Adaptability Scale", "Emotional Autonomy Scale", "Functions of Identity Scale", "Career Decision Making Self-Efficacy Scale" were used and data was collected using a personal information form created by the researcher. The theoretically constructed model was analyzed by Structural Equation Modeling (SEM) and bootstrapping technique. According to SEM results, career adaptability is affected directly by emotional autonomy and functions of identity and at same time it is influenced through career decision-making self-efficacy as a mediating variable. The established model was validated by both direct and mediating effects between variables. The results and limitations of the study were discussed within the framework of the past studies.
Моделирование устойчивости электромеханического преобразователя при осевых нагрузках
Authors: Ким К.К. , Колесник М.Б. , Иванов С.Н.
Published: July 2022

Приведен алгоритм исследования электромеханического преобразователя при осевых нагрузках. Объектом моделирования является асинхронный электродвигатель с интегрированным механизмом линейного перемещения, предмет исследования - механические напряжения, возникающие в конструкционных элементах двигателя. Представлены результаты моделирования и анализа механической устойчивости. Экспериментальные результаты получены с использованием пакетов T-Flex и SolidWorks Simulation. На основе зависимостей, полученных применительно к электроприводу задвижки трубопровода, показана возможность определения вращающего момента двигателя, нагруженного осевыми напряжениями. Предложенный подход позволяет минимизировать мощность электропривода при вариативности осевых нагрузок.
1. Sınıf Öğrencilerine Çıkarma İşleminin Öğretiminde Drama Yönteminin Kullanımından Yansımalar
Authors: ÇOLAK Gülçak , AYDOĞDU İSKENDEROĞLU Tuba
Published: July 2022

Bu çalışmanın amacı, yaratıcı drama yöntemi ile işlenen matematik dersinin sınıf içindeki yansımalarını ortaya koymak ve ders sonrasında öğrencilerin görüşlerinin belirlenmesidir. Araştırmada ilköğretim 1. sınıfa devam etmekte olan 14 öğrenci ile yaratıcı drama yöntemi kullanılarak matematik dersi yapılmıştır. Bu araştırmada nitel araştırma yaklaşımı benimsenmiş ve veriler gözlem, sınıf ortamında çalışma yaprakları uygulanarak ve uygulamanın sonunda seçilen bazı öğrencilerle görüşme yapılarak toplanmıştır. Ardından veriler betimsel analiz kullanılarak analiz edilmiştir. Araştırmanın sonucunda yaratıcı drama yönteminin matematik dersi için uygun bir yöntem olduğu, öğrencilerin ders süresince aktif olmalarının matematik dersine karşı motivasyonlarının artmasına katkı sağladığı sonucuna varılmıştır. Ders sürecinde kullanılan materyallerin dersi somut hale getirmesi çıkarma işlemi konusunun öğrenilmesini kolaylaştırdığı görülmüştür. Bu sonuçlar doğrultusunda yaratıcı drama yönteminin öğrenme ortamlarında daha sık kullanılması, öğretmenler için seminerler ve ilgili kitapların oluşturulması gerektiği önerilmiştir.
[RETRACTED] TestoChews – Real Customer Review After 30 Days v1
Authors: not provided portanolrena
Published: July 2022

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Authors: not provided jhontyrodes
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Authors: Hung Tsu-Chun
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A study of the Inverse Gaussian Process with hazard rate functions-based
drifts applied to degradation modelling
Authors: Rodríguez-Picón Luis Alberto , Méndez-González Luis Carlos , JC Pérez-Olguín , Iván , Hernández-Hernández Jesús Israel
Published: July 2022

The stochastic modelling of degradation processes requires different characteristics to be
considered, such that it is possible to capture all the possible information about a phenomenon under study. An important characteristic is what is known as the drift in some stochastic
processes; specifically, the drift allows to obtain information about the growth degradation rate of the characteristic of interest. In some phenomenon’s the growth rate cannot be
considered as a constant parameter, which means that the rate may vary from trajectory to
trajectory. Given this, it is important to study alternative strategies that allow to model this
variation in the drift. In this paper, several hazard rate functions are integrated in the inverse
Gaussian process to describe its drift in the aims of individually characterize degradation
trajectories. The proposed modelling scheme is illustrated in two case studies, from which
the best fitting model is selected via information criteria, a discussion of the flexibility of the
proposed models is provided according to the obtained results.
Empirical Validation of a Model for Predicting Students' Sense of Belonging and School Engagement as a Function of Classroom Management Practices
Authors: St-Amand Jérôme , Smith Jonathan , Rasmy Aziz
Published: July 2022

Over the last two decades, several studies have overlooked at-school belonging and engagement, two dimensions that are associated with several positive outcomes. However, the relative influence that contexts and interventions may have on these components has received much less attention. In this study, school belonging and engagement were examined as a function of the implementation and application of classroom rules. The study took place in two Moroccan schools, and participants were 238 students from 9th grade (101 boys, 137 girls; Mage = 15.1) living in the cities of Casablanca and Témara. They all completed a questionnaire that allowed to measure their belonging and engagement in conjunction with the manner in which rules are implemented and applied. Correlational and structural equation modeling methods were used to analyze the aforementioned relationships. Results showed that implementation of classroom rules had a positive effect on school belonging, which, in turn, had a positive effect on school engagement. These results indicated the need to conduct further empirical research to measure the contribution of classroom management practices on school belonging.
Exploring Expressions of Possible Selves with High School and College Students with Learning Disabilities
Authors: James Morgan Branch , Williams Sarah Carver , Hock Michael F. , Inlow Jamie S. , Moore Dominic A. , Jones J. Tanner
Published: July 2022

In this article, we explore a program designed to engage high school and college students with learning disabilities (LD) in conversations about their hopes, expectations, and fears for the future. We explore the mindset of students by focusing on their self-identified passions for life and sense of strengths and limitations. We found that males and females differed in goals related to Academics, Work Ethic, Degree Specific Statements, and Money and Finances. For example, females emphasized “Academic Goals” more frequently than males and focused on topics such as GPA and work ethic in school. However, males made more “Degree Specific Statements” than females, more often emphasizing the desire to be financially stable or have a career with a large income. These differences suggest that college transition staff may want to focus on goals identified by male and female students with LD as a way to be more responsive to student self-identified goals.
Adaptability, Personality, and Social Support: Examining Links with Psychological Wellbeing Among Chinese High School Students
Authors: Holliman Andrew , Cheng Feifei , Waldeck Daniel
Published: July 2022

The first year of boarding senior high school marks a period of great change for students. The extent to which students are able to adjust to successfully navigate this change (adaptability) likely has an impact on their psychological wellbeing. It has also been theorized that students’ personality traits and perceived social support may impact upon their adaptability and, directly and/or indirectly through adaptability, influence their psychological wellbeing. However, the literature examining independent and mediating effects of adaptability on psychological wellbeing is sparse particularly among students from non-Western cultures. In the present study, 102 grade-one high school students in China, were surveyed for their personality, perceived social support, adaptability, and psychological wellbeing (life satisfaction, mental well-being, and psychological distress). Findings showed that adaptability (along with neuroticism, extraversion, and social support) made a significant independent contribution to students’ psychological wellbeing. Further, adaptability was found to fully mediate the relationships between personality (conscientiousness and neuroticism) and psychological wellbeing, and to partially mediate the relationships between extraversion and psychological wellbeing, and social support and psychological wellbeing. These findings have important theoretical and practical implications for researchers and educators who are seeking to support students’ adjustment to boarding senior high school.
Basic Psychological Needs, Class-related Emotions and Satisfaction with Life in Spanish Teachers
Authors: Fierro-Suero Sebastián , J. Almagro Bartolomé , S. Becker Eva , Sáenz-López Pedro
Published: July 2022

The objective of this study was to examine possible antecedents and consequences of teachers’ emotions in the classroom. Based on a cognitive-social perspective and self-determination theory, we examined the relationship between basic psychological needs (BPNs), teachers’ class-related emotions and teachers’ life satisfaction. A sample of 595 teachers from Andalusia (Spain) participated in an online survey. A structural equation model was tested, in which BPNs predicted teachers’ emotions (β = .69; p < .001 positive emotions and β = -.42; p < .001 negative emotions). In addition, BPNs (β = .36; p < .001) and positive emotions (β = .23; p < .001) predicted satisfaction with life. The results show that the fulfilment of work-related BPNs is important to generate positive emotions and well-being in teachers. In addition, the study is the first to provide extensive details on the psychometric properties for assessing teacher emotions with the Achievement Emotions Questionnaire - Teachers (AEQ-T) in a Spanish sample.
Multi-level PWM Inverter for PV Systems Improving the THD
Authors: Simran Shainey , Nayak Roshan
Published: July 2022

In the last few years, the use of semiconductors in the electronic market has increased a lot, due to which its utilization in power electronic devices has also increased greatly, including UPS, AC drives, HVDC transmission line rectifiers, inverters and many more. We categorize the inverter in many ways like diode line capacitor cascade h-bridge diode climb like this but we do voltage source inverter in two ways if we look like multi-level inverter then two-level inverter multi-level letter Maybe and we are using multi-level inverter here. In this paper, we are discussing the performance of second level inverter using space vector PWM and further using for mains performance using disposition multicarrier moderation. In this paper we are using fuzzy logic to control WM, the factors we are working out are the total harmonics distortion switching frequency switching losses and the number of switching devices. Here the complete simulation is using MATLAB/Simulink software.
Quality Testing of Raw and Filtered Grey-water Emerging from Kitchen Sink: A Case Study
Authors: Paithankar Deepak N , Kumar Shashi R
Published: July 2022

The limited freshwater supplies in arid regions have created alternative water management strategies. Data indicates that
grey-water generation varies from 39-85% in various countries. Grey-water treatment and reuse can be a helpful nonpotable water source for toilet draining, watering gardens, car and floor washing, etc. Treated grey-water should be clean,
hygienic, environment-friendly and cost-effective. The goal of this research is (i) to test the parameters of raw grey-water
(ii) create a filter bed (iii) test parameters of treated grey-water (iv) Compare the parameters of raw and treated grey-water
(v) describe the area of use.
Fear of COVID 19 and the relation to resilience, meaning in life and subjective well being - Comparison between American and Israeli health care workers
Authors: Armstrong Amy , Hawley Carolyn , Su Ya , Marmor Anat , Sviri Sigal , Schwartz Isabella , Siri Shimon , Meiner Zeev
Published: July 2022

While COVID-19 has had a detrimental impact on most of the world's population, it has especially affected health care workers (HCWs) who are on the front lines fighting the virus. How HCWs cope with the pandemic have recently been explored. Differences across cultural and health care system settings related to fear of COVID 19 and measures of wellbeing may provide further insight to the coping mechanisms and experiences of HCWs during this worldwide pandemic. The overall subjective well-being and meaning in life scores are noticeably higher for the American participants whereas the fear of COVID and resilience scores are close in both studies, with slightly higher resilience and lower fear in the Israeli HCWs. Age, ethnicity and lower resilience were found to be significantly associated with higher fear of COVID-19 in both cohorts. In the Israeli participants, education level and life satisfaction were also associated with lower fear of COVID19 whereas in the American cohort, gender and relationship were also associated. These results suggest that albeit the cultural differences, similar mechanisms namely age and resilience, are important in coping with fear of the COVID-19 pandemic among both cohorts of HCWs. Therefore, it is important to enhance resilience in order to reduce the psychological burden of the pandemic among HCWs. This study was conducted prior to the availability of a vaccine.
Breast Ultrasound: Pitfalls, Tricks, and Tips. An Approximation for Radiologists in Training
Authors: Chico Maria , Swiecicki Maria , Pesce Karina , Andrieu Pamela
Published: July 2022

Breast ultrasound diagnostic performance depends not only on the operator's experience but also on the correlation of the results with other modalities. Therefore, a strong understanding of the acquisition technique and imaging optimization and the potential pitfalls in interpreting these studies is essential for achieving an adequate diagnosis. However, the trainees’ exposure to image optimization and ultrasound physics may be limited, impacting the quality of the examinations. Therefore, this review aims to provide an approach to breast US acquisition and interpretation, highlighting and illustrating tips for avoiding misinterpretations, mainly for trainees.
Cardiovascular Outcomes associated with Oral Anticoagulants, Antiplatelets and No-Treatment after Atrial Fibrillation Ablation: A Nationwide Cohort Study
Authors: Karasoy Deniz , Gislason Gunnar , Torp-Pedersen Christian , Olesen Jonas , Anselmino Matteo , Fruelund Patricia , Larsen Jacob , Riahi Sam
Published: July 2022

Objective: We investigated the long-term cardiovascular outcomes associated with direct oral anticoagulants (DOACs), antiplatelets and No-Treatment compared to warfarin beyond 90-days after atrial fibrillation (AF) catheter ablation. Methods: We identified 12,010 AF patients undergoing first-time ablation in Denmark (2002-2018) and analyzed stroke, serious bleeding, cardiovascular death and the composite of these three endpoints (MACE) by incidence rates (IR) per 1000 person-years and Cox proportional-hazard models. Results: The median age was 62 years (interquartile range [IQR]: 54-68 years); 28.8% were female, 7225 (60.2%) patients were younger than 65-years, and 6927 (57.7%) patients had CHA2DS2-VASc score≥2. Over a total of 65,990 person-years follow-up commencing 90-days after first-time ablation, warfarin, DOACs, antiplatelets and ‘No-treatment’ exposures covered 30,877 (46.8%), 9,452 (14.3%), 6,003 (9.1%) and 19,657 (29.8%) person-years, respectively. There was no difference between DOACs vs warfarin (HR 1.04 [0.77-1.42]95%CI) while antiplatelets (HR 1.50 [1.11-2.05]95%CI) and No-Treatment (HR 1.50 [1.15-1.94]95%CI) were associated with a significantly higher rate of stroke. DOACs (HR 0.70 [0.54-0.92]95%CI), antiplatelets (HR 0.58 [0.41-0.82]95%CI) and No-Treatment (HR 0.52 [0.39-0.69]95%CI) were associated with a significantly lower rate of serious bleeding compared with warfarin. We found no difference between DOACs and warfarin (HR 0.87 [0.61-1.25]95%CI) while Antiplatelets (HR 1.42 [1.04-1.94]95%CI) and No-treatment (HR 2.77 [2.16-3.56]95%CI) were associated with a significantly higher rate of cardiovascular death. We observed no difference with DOACs (HR 0.86 [0.70-1.05]95%CI), antiplatelets (HR 1.04 [0.84-1.27]95%CI) or No-Treatment (HR 1.10 [0.93-1.31]]95%CI) compared to warfarin in multivariable analyses regarding the composite endpoint of MACE. Conclusions: Our study indicates a better bleeding risk profile associated with DOACs than warfarin in patients undergoing AF ablation, but no difference for the endpoints of stroke, cardiovascular death, or the composite endpoint of MACE. Despite the favourable bleeding risk, antiplatelets and No-Treatment compared with warfarin appear hazardous due to a higher rate of stroke and cardiovascular death.
The Influences of COVID-19 Lockdown Measures on Physical Activity, Sedentary and Screen Time Behaviour of University Rugby Players in the Western Cape, South Africa
Authors: Young MEM. , Petersen TL. , Reid DL. , Magerman Z.
Published: July 2022

The COVID-19 pandemic has brought on many challenges to everyday life. The pandemic caused many lifestyles changes with social distancing becoming essential to prevent the spread of the virus and ensuring the safety of individuals. The main concerns were the influence on physical activity levels. Lockdown measurements restricted access to equipment and facilities that affected rugby players' training needs. Universities turned to online learning requiring student-athletes to spend more screen time, leading to sedentary behaviour affecting overall performance and well-being. This study aimed to explore the influences of COVID-19 lockdown measures on physical activity levels, screen time usage, and sedentary lifestyle among rugby players at a university in the Western Cape. Ethics was obtained from the University of the Western Cape Humanities and Social Sciences Research Ethics Committee (HS21/5/20). An exploratory qualitative approach was followed. Online semi-structured interviews were conducted with ten rugby players (5 males, 5 females), purposefully selected from a historical disadvantaged institution in the Western Cape. Data collected were transcribed verbatim, and Atlas Ti V9 was used to conduct thematic analysis. Trustworthiness was ensured using member checks, building a coherent justification for themes, rich, thick description to give context to the study, and describing the behaviour and experiences of the participants to convey the findings in a way that was understandable. The main findings of this study are summarised in three themes (physical activity, sedentary behaviour and screen time use) and eight sub-themes that emerged from the data. The key findings showed that most participants struggled to remain physically active throughout the strict lockdown measures due to a lack of support from coaches and the closure of sports facilities. Participants were once that it caused a significant decrease in a player's level of physical activity leading to an increase in sedentary behaviour and screen time usage. The changing institutional landscape also caused players to spend more time online, contributing to the sedentary lifestyle. Support from coaches during pandemics or situations where social engagement is restricted is of the essence. This includes emotional support, exercise programs, and sourcing equipment for rugby players to remain physically active and fit.
Unresectable Hepatoblastoma, Living Donation and Pre-Transplant Factors Associated with Event-Free Survival
Authors: Neto Joao , Feier Flavia , Pugliese Renata , Candido Helry , Porta Gilda , Miura Irene , Chapchap Paulo , Fonseca Eduardo
Published: July 2022

Background: The mainstays of irresectable hepatoblastoma (HB) treatment are surgical resection and cisplatin based (CB) chemotherapy (CHT). However, adequate patient selection is a key to achieve acceptable disease-free survival in patients with unresectable HB undergoing liver transplantation (LT). Procedure: This single-center retrospective analysis of 28 children with HB submitted to LDLT from 1996 to 2019 aimed at determining the pre-transplant factors associated with worse post-transplant event-free survival. The clinical variables collected were gender, age, PELD score (Pediatric End-Stage Liver Disease scoring system), type of neoadjuvant CHT (CB versus other regimens), pre- and post- CHT AFP levels, %AFP reduction post CHT (AFP pre-CHT – AFP post- CHT /AFP pre- CHT), PRETEXT stage, primary versus rescue LDLT, time between diagnosis and LDLT, presence of metastases at diagnosis, follow-up time. Results: Patients were divided in groups according to the occurrence of the event (recurrence/death) after LDLT – 10 patients in the event-yes and 18 patients in the event-no. Probability of 5-y event-free survival was 63.9%. AFP reduction < 70% (HR=4.33, 95%CI 1.1 to 16.95, p=0.03), and time from diagnosis to LT > 12 months (HR=4.11, 95%CI 1.14 to 14.76, p=0.03) were associated with higher recurrence/death in the Cox regression analysis. Alpha-fetoprotein (AFP) reduction post-CHT > 70% had a good performance in determining disease-free survival, with a calculated AUC of 0.8. Conclusion: LT for HB is the preferred treatment option for unresectable HB, with no distant metastasis and adequate response to CHT. AFP reduction < 70%, and time from diagnosis to LT > 12 months were associated with higher recurrence/death However, due to the limited number of patients in this study, a larger number of patients is required to corroborate these findings.
A Synthetic Small Molecule Carbazole SH-I-125 Degrades Androgen Receptor and Overcomes Castration-Resistance and Enzalutamide-Resistance in Prostate Cancer Cells
Authors: Amin Karishma , Hou Shu-Jie , Brown-Clay Joshua , Brown Milton , Banerjee Partha
Published: July 2022

Resistance to clinical anti-androgens is an ongoing problem in the treatment of castration-resistant prostate cancer (CRPC). Although second generation anti-androgens demonstrate initial clinical benefit, patients often develop resistance to these therapies, evidenced by rising serum PSA levels and disease progression. Several mechanisms including the expression of androgen receptor (AR) splice variants contribute to the reactivation of AR signaling in drug-resistant prostate cancer. Novel therapies that target AR signaling and suppress growth in castration-resistant and anti-androgen-resistant prostate cancer are essential for the effective management of advanced disease. We developed a synthetic small molecule analog of mahanine, SH-I-125, a compound with the ability to disrupt androgen receptor signaling and induce apoptosis in castration-resistant and drug-resistant prostate cancer cellular models. SH-I-125 disrupted AR signaling and induced apoptosis in CRPC cells and anti-androgen-resistant prostate cancer cells in a manner more effective than clinical anti-androgens, enzalutamide and ARN509. Furthermore, SH-I-125 decreased full-length AR and its splice variant AR-V7 levels in 22Rv1 prostate cancer cells by a proteasome-dependent mechanism. These findings indicate the therapeutic potential of SH-I-125 in prostate cancer patients that have progressed on currently approved therapies for CRPC.
Researches on the COVID-19 epidemic in the world within a nonextensive SIR model
Authors: Liu Yang , Yu Chen-Yue , Shen Ke-Ming
Published: July 2022

The coronavirus disease 2019 (COVID-19) epidemic was investigated within a general Susceptible-Infectious-Removed (SIR) model, especially the distributions of its dead cases and infectious ones. This paper applied its nonextensive modification with respect to more realistic situations. A time-dependent SIR model was modified when particularly regarding control and mitigation measures in response to the societal impacts of epidemics and pandemics. We validated all the theoretical results by fitting the derived q -distributions with data from the COVID-19 pandemic in the world. It was found that not all the changeable fit parameters are independent, some of which shared common properties, a result corroborated by our model prediction. Our modified SIR model was proved to be effective in fitting the COVID-19 epidemic distributions. The relative non-extensive parameter was strongly connected with the freedom of systems, which thus threw a light upon the prevention and treatment of disease next in the world.
ARCH-GARCH Analysis: An Approach to Determine The Price Volatility of Red Chili
Authors: Lestari Etty Puji , Prajanti Sucihatiningsih Dian Wisika , Wibawanto Wandah , Adzim Fauzul
Published: July 2022

Red chili is an agricultural commodity with high price volatility. Several previous studies stated that volatility was caused by weather effect on red chili production and shocks on public consumption. However, the other research stated that volatility was caused by the government’s import of red chili. This research aimed to analyze the price volatility of red chili in Semarang Regency on January 2019 to February 2020. The ARCH-GARCH method was applied in this study. This research showed that the price volatility of red chili occurred at the beginning, middle, and end of the year due to climate change, changes in public consumption patterns on religious holidays, and oversupply. However, the prevalence of Indonesia’s imports of red chili did not affect the price volatility. The government is suggested to implement a mapping policy and planting patterns to ensure the supply of red chili.
The Role of Gratitude and Family Support on Psychological Well-Being of Mothers with Autistic Children
Authors: Hizbullah Kahfi , Mulyati Rina
Published: July 2022

Having a child with an autistic spectrum disorder is a challenge for parents, especially mothers, which can hinder the fulfillment of optimal psychological functions so that the mother’s psychological well-being is disturbed. Internal situations such as gratitude and the presence of external support from the family can be factors that can encourage increased psychological well-being in mothers. This study observed the effects of gratitude and family support on mothers’ psychological well-being with children with an autism spectrum disorder. The instruments in this study used the gratitude scale, the family support scale and Ryff’s Psychological Well-Being Scales-short version distributed online. The subject in this study was 98 people, and the data collected were analyzed using the Doubled Linear Regression test using JASP software. The results showed the significance value of p0.05; thus, gratitude and family support had a role or effect on mothers’ psychological well-being with children with an autism spectrum disorder. Meanwhile, the effective contribution for gratitude was 17.39%, and family support was 21.53%. For future research, gratitude and emotion-based therapies such as emotion regulation training can be used as an intervention in experimental research to improve psychological well-being.
Functional and radiological outcome of autologous platelet rich plasma in chronic plantar fasciitis: A prospective study
Authors: Parikh Dharav Shekhar , Kumar R. Surendher , D Rajarajan , Kumar G Prasanna
Published: July 2022

Plantar fasciitis is one of the most common causes of foot pain. It results from sustained stress of weight bearing - hopping, jumping, running -which results in micro trauma to plantar fascia which further leads to plantar fasciitis. It constitutes 11% to 15% of all foot symptoms. Its prevalence is 8% to 10% in general population. It commonly affects at the age of 40 to 60 years. Recently platelet rich plasma was used in treating in degeneration, muscle and tendon injuries. Hence, the present study aimed to assess the treatment outcome of autologous platelet rich plasma injection in treatment of plantar fasciitis.

In this prospective study, we enrolled 35 patients with plantar fasciitis coming to OPD or casualty. Patients satisfying inclusion criteria were selected based on consecutive sampling. 11 patients responded well to conservative management and 3 patients had loss of follow up. The different scoring systems were adopted such as VAS and AOFAS for pain assessment. The thickness of plantar fascia was determined by ultrasound technique. Autologous platelet rich plasma was prepared and the same was injected. The outcome analysis was done at 2 weeks, 3 months, and 6 months; and compared with pre injection values.

From pre-injection to up to post-6 months period, the VAS reduction was statistically significant (P<0.0001). All the time interval, the AOFAS was increased which was statistically significant (P<0.001). The injection was effective in reducing the thickness of plantar fascia, which was found to be statistically significant at all the time intervals (P<0.001).

Autologous PRP injection for chronic plantar fasciitis was found to be an effective treatment modality for chronic plantar fasciitis.
Efficacy of intra-lesional injection of platelet rich plasma in reccurent plantar fasciitis- A case study
Authors: Das Partha Pratim , Das Chinmoy
Published: July 2022

Planter fasciitis is the most common cause of heel pain in patients attending the orthopaedic clinics. Pathophysiology involves micro tears in the tendon leading to haemorrhage, rough granulation tissue formation and later repair. Even though the different treatment modalities have been claimed to be effective in treating this condition due to its chronic nature and tendency to recur with resumption of activity, no single modality has been considered. Platelet-rich plasma (PRP) injection as a treatment that has been used in recent times for various enthesopathies. It repairs incompletely healed injuries thereby reducing pain and increasing function. We report a series of 5 cases of recurrent Plantar Fasciitis treated with PRP injections.
Arthritis with osteoporosis crippled the elderly during Covid-19 pandemic: A silent killer?
Authors: Govil Gaurav , Tomar Lavindra , Dhawan Pawan
Published: July 2022

The COVID-19 pandemic impacted the elderly both directly by the affection due to infection and indirectly by the aggravation of the pre-existing medical comorbidities. The management of the chronic diseases took a relative back-seat for an active treatment protocol strategy. The clinicians emphasised on the conservative measures to manage arthritis and osteoporosis. The delayed assessment had a profound negative impact with significant progression of arthritis and osteoporosis amongst the elderly.

The crippling effect of COVID-19 pandemic in the elderly presented furthermore with the advanced stages of arthritis and worsened osteoporosis for the management. The delay in timely offer of surgery for the arthritic joint compromised the functional outcomes. There has been a silent worsening with increased morbidity and mortality.

The literature review and guidelines formulated emphasized on the timely remedial measures either surgical or conservative for the management of arthritis and osteoporosis in an elderly to halt the silent progression, allow a healthy lifestyle with an improved quality of life. The elderly should have priority for an individualized management strategy even during the pandemic to reduce this “silent” morbidity and mortality.
As implicações da senciência de peixes: qual é o impacto do bem-estar animal na piscicultura e na qualidade da carne?
Authors: Fernandes Laylla Nunes , Melo Letícia Maria De , Lima Marieli De
Published: July 2022

A senciência e o bem-estar na cadeia produtiva de peixes durante algum tempo foram negligenciados. Atualmente, estudos buscam entender a relação entre o estresse e as alterações provocadas nos peixes. O objetivo desta revisão de literatura foi reunir dados hematológicos, bioquímicos, neurofisiológicos e comportamentais de peixes frente ao estresse nessa cadeia produtiva. Para a busca de conteúdo utilizaram-se sete bases científicas e as seguintes palavras-chave: animal welfare, stunning method, fish, stress, slaughter, humane slaughter, capturing stress, effect of quality e shelf-life. Para a elaboração da revisão foram utilizadas 42 referências. Os dados revelaram que a criação, captura e transporte de peixes de maneira inadequada podem desencadear maiores níveis de cortisol plasmático, alimentação e crescimento prejudicados. Alternativas como renovação de água em tanques de criação ou estratégias alimentares (uso de óleos essenciais, cúrcuma e probióticos) podem reduzir o estresse e seus prejuízos, propiciando bem-estar na aquicultura. O abate é uma etapa crítica na obtenção de peixes, principalmente se realizado por métodos não humanitários. Pesquisas demonstraram que a insensibilização ou o abate por termonarcose (hipotermia) e o abate por corte branquial favorecem comportamentos aversivos, relativa demora em inconsciência, rápida depleção de ATP, prejuízo ao rigor mortis e na qualidade e rendimento da carne (coloração, textura, oxidação lipídica e desnaturação proteica). Eletrocussão, uso de gases, percussão e a combinação entre esses métodos demonstram ser mais humanitários, favorecendo a qualidade da carne. Porém, as operações de insensibilização e abate são variáveis, sendo necessários mais estudos que definam padrões humanitários para espécies na aquicultura.
Relação entre a assistência estudantil e a proposta curricular de ensino médio integrado no âmbito do Instituto Federal da Paraíba (IFPB)
Authors: Santos Jessyca Mayara Nunes dos , Almeida Emmanuelle Arnaud , Monteiro Nerijane De Almeida , Silva Edna Dias da
Published: July 2022

A Educação Profissional e Tecnológica possui como um de seus pressupostos a transformação de realidades, sobretudo a dos mais pobres. A assistência estudantil surge com o objetivo de disponibilizar a esse público o mínimo necessário para que possa acessar a educação de modo efetivo. Nesse sentido, o objetivo geral do presente estudo é analisar a relação entre a assistência estudantil e a proposta curricular do ensino médio integrado no contexto do Instituto Federal de Educação, Ciência e Tecnologia da Paraíba (IFPB), tendo como base princípios orientadores da proposta curricular de Libâneo (2015). Para tanto, procedeu-se à análise do Projeto Pedagógico-Curricular do Curso Técnico Integrado em Mineração do IFPB – Campus Campina Grande, de modo a identificar elementos que relacionem os pressupostos da assistência estudantil e da organização curricular de Libâneo com o referido curso. Trata-se, pois, de uma pesquisa qualitativa, de classificação teórica, com tipologia bibliográfica e documental. Entre os resultados obtidos tem-se a compreensão de que a inclusão social, a diversidade cultural e a participação coletiva são conceitos indissociáveis na formulação de uma proposta de currículo integrado que tem como alvo a educação igualitária e emancipatória dos sujeitos, em que a assistência estudantil agrega-se como facilitador dessa proposta, sendo indispensável enquanto houver desigualdades no contexto estudantil.