bluuebunny/crossref_metadata_2025 huggingface dataset:
Rewizja i kodyfikacja kanonów we współczesnym prawosławiu
Authors: Kałużny Tadeusz
Published: March 2024

Celem niniejszego artykułu jest prezentacja istotnych aspektów aktualnej debaty na temat rewizji i kodyfikacji kanonów w Kościele prawosławnym. Temat został rozwinięty w czterech częściach. Na początku zwrócono uwagę na problemy w stosowaniu dawnych kanonów w życiu dzisiejszego Kościoła prawosławnego. Następnie ukazano wysuwane propozycje i podejmowane we współczesnym prawosławiu próby kodyfikacji kanonów. W trzeciej zaprezentowano poglądy współczesnych teologów i kanonistów prawosławnych na temat potrzeby i możliwości realizacji tego przedsięwzięcia. W końcowej części zestawiono wyniki refleksji i sformułowano wnioski. Z przeprowadzonych badań m.in. wynika, że propozycja rewizji i kodyfikacji świętych kanonów nie jest w sposób jednolity postrzegana przez teologów i kanonistów prawosławnych. W podejściu do tej kwestii można odnotować dwa przeciwstawne stanowiska: zwolenników i przeciwników. Ostatecznie stwierdzono, że właściwym forum dla wypracowania wspólnego stanowiska w badanej sprawie jest sobór całego prawosławia.
Chrystologia na Filipinach
Authors: Klejnowski-Różycki Dariusz
Published: March 2024

Filipiny w religijnej mozaice Azji stanowią pewien wyjątek: są krajem, gdzie większość obywateli jest katolikami. Jest to kraj podbity najpierw przez Hiszpanów, następnie przez Amerykę. Rażące różnice społeczne wywarły także znamię na duchowości Filipińczyków. Chrystologia na Filipinach kształtuje się pod wpływem kultu Dzieciątka Jezus (Santo Niño), Cierpiącego Chrystusa „Czarnego Nazarejczyka”, obrzędów Wielkiego Tygodnia, w którym wyśpiewywany jest epicki utwór Pasyon Pilapil, co utrwala – zdaniem wielu teologów – postawę bierności i cierpiętnictwa. Z drugiej strony teologowie uprawiają specyficznie filipiński nurt teologii wyzwolenia – „teologii walki” odwołując się do przesłanek Biblijnych w Starym Testamencie jak i w Nauczaniu Pana Jezusa. Równowaga między tymi dwoma nurtami jest dużym i inspirującym wyzwaniem chrystologii.
Editorial: Interpretação da Bíblia na Igreja
Authors: Silvano Zuleica Aparecida
Published: March 2024

Celebram-se os 30 anos do Documento da Pontíficia Comissão Bíblica, finalizado no dia 15 de abril de 1993, em língua francesa, mas publicado oficialmente, e em todas as línguas modernas, no dia 18 de novembro de 1993. Esse tema foi estudado pela Comissão Bíblica entre os anos de 1989 a 1993, quando o texto foi finalizado. No dia 23 de abril de 1993, o papa João Paulo II convocou o Colégio dos Cardeais residentes em Roma, o corpo diplomático, os professores do Pontifício Instituto Bíblico e os membros da Comissão para uma audiência solene, com o objetivo de comemorar o centenário da publicação da encíclica Providentissimus Deus (1893), de Leão XIII, o cinquentenário da Divino Afflante Spiritu (1943), de Pio XII, e comentar o novo documento. Nessa ocasião o documento “Interpretação da Bíblia na Igreja” foi aprovado.
Os peixes na reflexão ecoteológica da Bíblia Hebraica
Authors: Grenzer Matthias , Gross Fernando
Published: March 2024

The millennial texts that form the Hebrew Bible bring with them a significant reflection on non-human beings, that is, abiotic beings, plants, and animals. Thus, an ecotheology is born that discovers nature as the word of God and sees the human being amid other creatures. Moreover, it indicates the urgency of respectful coexistence and the ethics of care and/or stewardship since all beings are residents of a common home. In the present study, the Hebrew Bible is visited in search of the thirty-four presences of the word commonly translated as "fish", knowing that there are no mentions of species of this aquatic animal. The aim is to bring together the elements that, present in different literary-historical contexts, establish an ecotheological reflection. Thus, the research proposed here is part of the green reading of biblical texts. Thirty years ago, at the time of the publication of the ecclesial document “The Interpretation of the Bible in the Church”, this theme had not yet gained greater visibility. Today, however, it is urgent.
Fundamentalismo e Dispensacionalismo
Authors: Xavier Liniker Henrique
Published: March 2024

In this article, we address the definition of modernity, highlighting how the evolution of this concept has repercussions in the realms of religion and individual identity, leading to a plurality that translates into a crisis of meaning. From this standpoint, the text connects such ideas with the theological and social responses that emerge as reactions to these phenomena. Subsequently, the focus shifts to the phenomenon of fundamentalism, treating it as a paradoxical consequence of modernity, which attempts to resolve the crisis of meaning by resorting to a strict interpretation of sacred texts. The analysis proceeds to discuss the impact of this fundamentalism on the attitudes of evangelical groups regarding conflicts in the Middle East, with special emphasis on the tension between Israel and Palestine. In this section, the article outlines how certain fundamentalist readings of the Bible, specifically dispensationalism, lead to a political interpretation of the sacred texts, contributing to a perspective that denies the principles of modernity and its complexities.
Os princípios da reforma do processo de nulidade matrimonial proposto pelo romano pontífice Francisco
Authors: Conceicao Wellington Reis da
Published: March 2024

One of the great concerns of Pope Francis' ministry is to promote a Church on the way out, in which people separated from the Church are effectively welcomed from a synodal perspective. Within this perspective, Pope Francis promulgated on August 15, 2015, the Motu proprio on the reform of the process for declaring marriage null and void, the Mitis Iudex Dominus Iesus for the Latin Church, and came into force on December 8, 2015, as per the can. 8, § 1. This article, whose theme is: the principles of reform of the marriage nullity process proposed by the Roman Pontiff Francis, indicates the origin of the fundamental legal principles that determined the changes promoted by the Pope and their possible applicability in diocesan Tribunals and Dioceses. Thus, the methodological itinerary was based on studies, analyzes of the motu proprio Dominus and Iesus, other documents and articles related to the topic, which are available in the bibliography of this article. The purpose of this article is to present the foundations of the changes implemented by Pope Francis and motivate Canonical Tribunals and Dioceses to implement these new developments with the primary objective of salus animarum, can. 1752.
Dos textos ao testemunho
Authors: Mareano Marcus Aurélio Alves
Published: March 2024

Este texto apresenta o testemunho de vida de Johan Konings, reconhecido biblista belga que exerceu maior parte do seu ministério no Brasil. Partiremos da descrição de alguns breves traços biográficos principais. Então, refletiremos a respeito de três aspectos, que destacamos da sua vida: a primazia da Palavra de Deus; a consideração pelos diferentes contextos; e a vivência da Palavra de Deus. Recorreremos aos textos escrito pelo autor e desenvolveremos algumas impressões pessoais. Ao final, perceberemos que a vida de Konings ensina, mais do que seus escritos, um modo de ser no mundo. Ele nos deixa um legado para aprendermos e seguirmos adiante.
Plantas medicinais utilizadas no processo de cicatrização de feridas
Authors: Gadelha Amanda Nerissa Lima , Aquino Greicy Kelly Sousa , Silva Flávia Garcez da , Reis Elaine Cristiny Evangelista dos
Published: March 2024

Objetivo: Identificar quais plantas medicinais são utilizadas no processo de cicatrização de feridas. Métodos: Revisão Integrativa de Literatura, a qual buscou respostas para a questão de pesquisa: Quais plantas medicinais são utilizadas no processo de cicatrização de feridas? Onde passou pelas seguintes etapas: 1. Elaboração da pergunta norteadora; 2. Estabelecimentos de critérios para inclusão e exclusão de estudos; 3. Busca ou amostragem de estudos na literatura; coleta de dados; 4. Análise dos estudos incluídos; 5. Discussão dos resultados e 6. Apresentação da revisão integrativa. Resultados: A análise dos dados coletados apontou que dentre as diversas plantas encontradas na natureza, a Aloe vera (Babosa), Calendula officinallis (Calêndula), Stryphnodendron barbatiman (Barbatimão) e Orbignya phalerata (Babaçu), além de possuírem ação antibacteriana e anti-inflamatória, também possuem propriedades cicatrizantes, sendo utilizadas no processo de cicatrização de feridas. Considerações finais: Diante dos dados, percebe-se que o uso de plantas medicinais se tornou uma alternativa, nas práticas integrativas e já tem destaque até mesmo na atenção primária, mostrando a necessidade de realizar novos estudos de comprovação científica, para atualizações das publicações.
Strategi Pemberdayaan Kepemudaan Dalam Meningkatkan Perekonomian Masyarakat Di Kedah
Authors: Hakim Arif Rahman , Hanafi Imam , Zuliana Azwa Zuliana Azwa , Mardiah Adwa
Published: March 2024

Peningkatan perekonomian masyarakat Malaysia terutama di Negeri Kedah melalui pemberdayaan kepemudaan masih ditenggarai memiliki beberapa permasalahan padahal peningkatan ekonomi dengan melibatkan kepemudaan sangat berperan untuk pembangunan jangka Panjang. Pengembangan kualitas, keterampilan, kepribadian serta kecakapan kepemudaaan jelas tidak bisa dicapai dengan hanya mengikuti pendidikan formal, tetapi dapat dilakukan melalui bentuk pemberdayaan kepemudaan dengan wadah organisasi atau kegiatan lainnya. Peningkatan ekonomi masyarakat di Kedah dengan pemberdayaan kepemudaan difokuskan melihat strategi yang tepat dalam pelaksanaan kedepan. Pelaksanaan peningkatan ekonomi masyarakat di Kedah sejauh ini belum berhasil dan membutuhkan peninjauan kembali terkait strategi yang digunakan. Hal ini disebabkan pemerataan sosialisasi pemerataan kinerja kepemudaan dan tingginya penolakan terhadap usia muda. Koordinasi kemitraan strategis antara pemerintah, swasta dan kepemudaan di Kedah dengan bantuan dalam bentuk dana dan peluang usaha sejauh ini masih belum berjalan secara efektif.
Upaya Meningkatkan Partisipasi Masyarakat Dalam Politik Dan Proses Pemerintahan Di Kedah
Authors: Syafhendry Syafhendry , Manaf Halimah Abdul , Novita Yosi , Saputra Siswan Ahmad
Published: March 2024

Partisipasi merupakan komponen penting dalam membangkitkan kemandirian dan proses pemberdayaan. Partisipasi aktif masyarakat dalam setiap proses pengambilan keputusan merupakan hal terpenting dalam pemberdayaan. Mulai menguatnya kesadaran politik yang menyuarakan dilaksanakannya proses demokratasi dalam praktik pemerintahan di Malaysia perlu mendapat perhatian serius, baik dari pemerintah Malaysia maupun pemerintah bagian di Kedah serta dari kelompok masyarakat yang ada di Kedah. Namun masih terdapat beberapa persoalan mendasar bagi upaya tumbuhnya proses demokratisasi politik dan pemerintahan di Kedah dan Malaysia pada umumnya. Pemecahan permasalahan ini perlu melibatkan lintas sector, adanya kerja sama yang baik antara pemerintah bagian Kedah, pemerintah Malaysia serta kelompok masyarakat sipil setempat untuk membangun partisipasi masyarakat di dalam proses politik dan pembangunan. Peningkatan Kerjasama dan Kolaborasi. Penting untuk membangun kemitraan yang kuat untuk membangun cultur demokrasi antara pemerintah Kedah, pemerintah Malaysia dan masyarakat sipil. Tujuan dari Kerjasama lintas sector disini adalah untuk meningkatkan partisipasi masyarakat untuk terlibat secara langsung dalam proses politik dan pembangunan di Kedah dan Malaysia.
Manajemen Tata Kelola Bumdes Dalam Pengembangan Usaha Di Bumdesa Karya Usaha Bersama
Authors: Zubaidah Evi , Rusadi Sylvina
Published: March 2024

Bumdes sebagai lembaga pengungkit perekonomian desa melalui peningkatan layanan umum dan mengoptimalkan asset desa, begitu juga dengan Bumdesa karya usaha Bersama merupakan lembaga yang melaksanakan berbagai program perekonomian yang memiliki beberapa uniat usaha yang berfungsi untuk menambah perekonomian masyarakat disekitar. Berdasarkan permasalahan yang dihadapi bumdesa karya usaha Bersama disalah satu unit usahanya yaitu unit usaha air minum masak masih mengalami kendala yakni dalam pencatatan laporan ke pihak manajer BUMDesa masih melakukan sistem manual sehingga sering terjadi kesalahan dan kekeliruan, hal ini menjadi perhatian untuk dilakukan pelaksanan pengabdian dengan cara Melaksanakan sosialisasi dan praktek ke pihak BUMDesa dan juga pegawai khusus yang ada di unit usaha Air Minum Masak tersebut, Dan juga dilakukan pendampingan langsung tentang tata cara penggunaan sistem elektronik tersebut yang sudah dibuat dan disiapkan oleh Tim PKM. Dengan adanya layanan digital tersebut diharapkan pegawai pada bagian unit usaha masak dapat menikmati layanan secara mandiri berbasis digital melalui smartphone untuk bisa terhubung langsung dengan manajer BUMDesa dan juga ke bagian bendahara Bumdesa untuk pelaporan setiap unit usahanya.
The solvability of difference schemes with universal approximation of ѕows in boundary conditions
Authors: Паасонен В.И.
Published: March 2024

Исследуется способ аппроксимации граничных условий с произвольным порядком точности, основанный на односторонних многоточечных разностных аналогах потоков максимально возможной точности на данном шаблоне. Рассматриваемая технология универсальна в смысле однообразия алгоритма при любых порядках точности схемы и в смысле независимости граничного условия от вида решаемого уравнения. Исследована проблема реализации и разрешимости разностной задачи путем приведения ҡдлинныхә граничных условий к эквивалентным двухточечным условиям. Сформулированы условия диагонального преобладания в строках матрицы приведенной системы, соответствующих граничным соотношениям. Показано, что обсуждаемая универсальная технология расчета, в отличие от традиционных способов, не порождает проблем при расщеплении многомерных задач на одномерные.

One of the ways of setting the difference boundary conditions with high order of accuracy is based on the direct multi-point one-sided approximation of the ѕows. Such boundary relations, unlike traditional ones, are universal in the sense of uniformity of their structure at different orders of accuracy, as well as in the sense of their independence from the differential equation being solved. In addition, this technology does not create any obstacles in splitting multidimensional problems into one-dimensional ones, since the boundary conditions turn out to be the same universal onedimensional ones at the intermediate steps. However, the number of nodes in the boundary relation stencil, i. e. the ҡlengthә of the boundary condition, increases as the order of accuracy of the scheme increases. This leads to a violation of the traditional tridiagonal structure of the matrices to be reversed, and a related violation of the diagonal predominance in the rows corresponding to ҡlongә boundary conditions. Although extensive experience of applying universal boundary conditions in numerical simulations of various types of boundary value problems has not revealed violations of computational stability, this technique required a theoretical justiҥcation. This paper addresses the question of the solvability of such problems and the stability of calculations when they are implemented by the proposed method. For this purpose, matrix rows with ҡlongә boundary conditions are reduced by means of local Gaussian procedures to equivalent short two-point rows, and the solvability and stability conditions for solutions of the transformed systems are established based on the requirement of a diagonal predominance in the transformed rows corresponding to the boundary conditions. A general criterion for diagonal predominance in a transformed string is formulated for an arbitrary order of ѕow approximation. For several difference schemes up to the fourth order of accuracy, it is found that the criterion is satisҥed unconditionally or under not burdensome restrictions on the ratio of grid steps.
New Learning Policies and The Impact of The Covid-19 Pandemic on Education in Indonesia
Authors: Sood Muhammad , Sada Clarry
Published: March 2024

The COVID-19 pandemic has spread throughout the world that has a very detrimental impact on many parties and paralyzed many sectors, including the education sector. The education system, especially in Indonesia, has become unstable due to the pandemic. New policies in learning have been initiated by the government still encounter any difficulties in their implementation. However, almost all elements of education have been complaining about this. The psychological impact is not only experienced by students, but educators and parents also experience mental health problems caused by the pandemic. Nevertheless, the responsibility cannot be imposed by the government only, but all layers of the existing educational elements must be able to work hand in hand, with the same conditions and unpreparedness. Therefore, education in Indonesia will be able to recover and operate again as it should, even though it must implement a new learning policy to prevent the spread of the COVID-19 pandemic.Keywords: COVID-19, Education, Learning Policy, Psychology, Indonesia
Developing Multimedia-Call in Writing Using Field Trip Animation Model for the Eight - Graders at SMPIT Al Mumtaz, Indonesia
Authors: Kurniawan Heri , Ikhsanudin Ikhsanudin
Published: March 2024

This research aimed to develop Multimedia Computer Assisted Language Learning (Multimedia CALL) using a field trip animation model (FTA model) into supplementary material for the eighth graders in writing recount text. It was a research and development study. The research subjects were 8th-graders from both homogeneous gender classes of SMPIT Al Mumtaz Pontianak. The research procedure systematically comprised need analysis, needs exploration, the contextual realization of the materials, pedagogical materials development, the physical materials design, and materials evaluation. The needs analysis results revealed that they needed the supplementary writing material, providing integrated reading and listening practices, along with multi facilities so that they were able to compose a topic about a sightseeing trip for 200 words or above. Therefore, the researcher designed four serial and contextual writing learning units, enhanced by the enriched multimedia CALL tools in the material. Besides, the material evaluation found the material was appropriate and practical for the students to write a recount text.Keywords: Development, writing learning material, recount text, field trip animation based model, and Multimedia CALL
Improving Students’ Reading Comprehension on Descriptive Text by Using Crossword Puzzle
Authors: Englis Nina , Sudarsono Sudarsono
Published: March 2024

The purpose of this research is to find out the improvement of students’ reading comprehension in finding general information, specific information and textual reference of the descriptive text by using crossword puzzle of VIIF of SMPN 19 Pontianak. The participants of the research were 17 male students and 15 female students. The researcher conducted classroom action research in two cycles. After implementing the crossword puzzle as the media of teaching descriptive text, the researcher found that 100% of the students could find general information, 87.5% of the students could find specific information and textual reference of the descriptive text about public building. It showed that crossword puzzle could improve students’ reading comprehension, in terms of finding general information, specific information and textual reference of descriptive text after using crossword puzzle. Further, crossword puzzle also could improve the students’ activeness in learning process, students’ spelling was also improved. The crossword puzzle gives benefits for the students. It is recommended for the future research to do the similar research by using crossword puzzle platform that can be accessed by mobile phone. Keywords: reading comprehension, descriptive text, action research
The Use of Bingo Game in Teaching Vocabulary to The Seventh Grade Students
Authors: Rahmaniah Sailatur , Salam Urai , Wardah Wardah , Regina Regina , Rezeki Yanti Sri
Published: March 2024

This research aimed to discover the use of the Bingo game on the students’ vocabulary of MTs Al-Jihad Pontianak. This research took a preexperimental study. The sample of this research was 22 grade 7a students with total cluster sampling method. The data on this study were gathered through a written test in the form of multiple choice consist of 20 items for both pretest and posttest. As a procedure, the researcher divided the students into four groups, then gave the students picture bingo. The researcher mentioned the name of the word of the pictures twice, the groups of students have to write the name of vocabulary that the researcher said. The group who has finished write vocabulary in every picture should shouts “Bingo”. The result of t-test was 22.20, higher than t-critical (22.20 > 2.051). It revealed that the null hypothesis (H0) was rejected and the alternative hypothesis (Ha) was accepted. Finding also showed that the score of the effect size of the treatment was 1,77, categorized as “strong” effect. It can be concluded that Bingo game has a strong significant effect on vocabulary achievement of grade 7 students of MTs Al Jihad Pontianak. Keywords: Bingo game, Pre-Experimental Research, Vocabulary
Improving Student’s Speaking Ability Through Role Play to Teach the Tenth-Grade Students
Authors: Chandra Lelyana , Salam Urai , Rosnija Eni , Wardah Wardah
Published: March 2024

The objective of this research was to improve the Tenth Grade students speaking ability of SMA Negri 3 Pontianak in the academic year 2021/2022 with the use of Role Play technique. It was a classroom action research which consisted of three cycles. The subjects of this research were students of Tenth Grade B Class. The data were qualitative data, it was collected by observing the teaching and learning process. The data were in the form of observation checklist and field note. The procedures of the research were planning, acting, observing and reflecting. The result of this research showed that use of Role Playing technique, it found that the speaking abilty of the student had singnificant improved, it helped the student to be more braver and confident to speak in English. The fluency and the elements of Role Play itself also helped them to enrich their speaking in English. Keywords: Role Play, Classroom Action Research, Speaking
Designing My Vocabulary Learning (MVL) as an Interactive Multimedia to Teach The Seventh-Grade Students of SMPN 3 Sungai Ambawang
Authors: Apmi Adrianus Tendi , Suhartono Luwandi , Bunau Eusabinus , Wardah Wardah
Published: March 2024

This research aimed to design MVL as interactive multimedia to support the process of teaching vocabulary to the seventh-grade students of SMPN 3 Sungai Ambawang. This research took the form of developmental research. The researcher has done three passes of ADDIE, which is ADD (Analysing, Designing, and Developing). While analyzing the data, the researcher followed the following six procedures: acquire involved with the data, create the initial codes, look for themes, identify themes, and compose them. The product was evaluated by expertise by looking at three criteria: correctness, reliability, and usability. The content analysis proceeds to be converted into descriptive data. The result of this study is an MVL product with three subtopic materials: things in the classroom, things in the kitchen, and things in the living room. Each subtopic consists of two activities: material and exercise. This product has been validated by an expert by using an assessment rubric based on three criteria: correctness, reliability, and usability.Keywords: Development Research, My Vocabulary Learning, Vocabulary Teaching, and Learning, Vocabulary
An Analysis of Students’ Speaking Anxiety in English Foreign Language (EFL)
Authors: Sundayanti Hestiana , Surmiyati Surmiyati , Bunau Eusabinus , Sumarni Sumarni
Published: March 2024

This research aimed at determining students’ speaking anxiety levels and how they anticipate or the strategies to reduce it. Researchers used a descriptive mixed approach to explore and explain data about student anxiety. This research involved 122 grade 8 students of SMP Negeri 3 Sungai Raya. In collecting data, researchers use the instrument FLSA questionnaire and interviews. From the results of the questionnaire, the categories of students’ anxiety were determined to be 3 categories of mild, moderate, and severe anxiety levels. The results showed that 15 students were at low anxiety level, 88 students were included in moderate anxiety, and 19 students were at severe anxiety level. Furthermore, the results of the interview, the way they anticipate speaking anxiety is by controlling their breathing, be brave, encourage themselves, and practice regularly. Keywords: Speaking Anxiety, EFL, Descriptive Study
Designing Cartoons for Mnemonic Strategy in Teaching Vocabulary of Analytical Exposition Text
Authors: Fitriani Nabila , Apriliaswati Rahayu , Bunau Eusabinus
Published: March 2024

The objective of this research was to design cartoons by using mnemonic strategy to teach the vocabulary in analytical exposition texts for the eleventh grade students of SMAN 6 Pontianak. This research followed the procedure of ADD (Analysis, Design, and Develop) phase of the complete procedure ADDIE. In Analyzing phase, the English teacher was interviewed after observing the class. In Designing phase, the first draft was produced after a process including searching for the texts and analyzing the vocabulary difficulty in those based on CEFR levels. In Developing phase, the cartoons were drawn and colored digitally using Clip Studio Paint. They were presented in A4 PDF document format using Canva as a tool to design the layout. To make the learning process interactive, the product was also cross-posted on liveworksheets.com. The complete development was followed by product evaluation. The result indicated that the product is categorized as “excellent” with the value of 3.89 using Likert Scale. This research produced a book entitled Analytical Exposition Text Vocabulary.Keywords: Cartoons, Mnemonic, Vocabulary
Analyzing The Speaking Anxiety of The Sixth Semester Students of English Language Education Department
Authors: Nuraprianti Yeni , Hertami Diah Ayu
Published: March 2024

In our globalized era, English has become the predominant language for communication. While mastering English speaking is essential, many students grapple with speaking anxiety. This research paper delves into the challenges students face in acquiring speaking skills and the strategies employed for overcoming them. Using a qualitative approach with a descriptive study method, the aim is to comprehend and articulate these issues. Data collection involved student questionnaires. Results reveal varying levels of speaking anxiety at Universitas Tanjungpura, with prevalent strategies for mitigation including increased practice, self-control, and preparation. These findings hold implications for educators and institutions, suggesting a need to tailor support and interventions to enhance students' English-speaking proficiency. Recognizing and addressing these challenges can contribute to more effective language education strategies in a globalized academic environment.Keywords: English language education students, speaking anxiety
Augmentation of Structure Information to the Sequence-Based Machine Learning-Assisted Directed Protein Evolution
Authors: Yutzy Lane , Nguyen Kenny , Vallet Peter , Li Jianxiong , Yu Jielin , He Ronggui , Yan Le , Kim Joohyun , Jung Jangwook
Published: March 2024

Directed evolution (DE) mimics natural selection to improve the functions of a target protein. Machine learning (ML) has significantly streamlined DE by aiding in several steps, which includes identifying starting variants, generating diverse libraries and modeling sequence-fitness relationships. To date, the majority of ML-assisted DE (MLDE) approaches has relied predominantly on sequence information due to the challenges and cost of obtaining protein structure information. Here, we introduce a structure-augmented MLDE (saMLDE) approach for selecting high fitness variants from a library of Protein G B1 domain. We adopted and applied a zero-shot sequence-based prediction method (offering the potential to discover new insights without extensive training data) to select an initial training library of 96 variants for the saMLDE campaign. To leverage protein structure information, we used protein structure prediction with AlphaFold2 and molecular docking simulations performed with Rosetta FlexPepDock, resulting in structure-based features derived with an induced fit model. After three rounds of the saMLDE campaign, we demonstrated that saMLDE incorporating structural information gradually improves the average fitness scores and the precision of predicted binders. In addition, we found that the initial library selection with zero-shot subset selection methods significantly impacted the average fitness scores and precision, consequently influencing the overall directed evolutionary trajectories.
Dark State Concentration Dependent Emission and Dynamics of CdSe Nanoplatelet Exciton-Polaritons
Authors: Chang Woo Je , Zeng Hongfei , Terry Weatherly Connor , Provazza Justin , Liu Pufan , Weiss Emily , Stern Nathaniel , Tempelaar Roel
Published: March 2024

The recent surge of interest in polaritons has prompted fundamental questions about the role of dark states in strong light-matter coupling phenomena. Here, we systematically vary the relative number of dark state polaritons by controlling the number of stacked CdSe nanoplatelets confined in a Fabry-Pérot cavity. We find the emission spectrum to change significantly with an increasing number of nanoplatelets, with a gradual shift of the dominant emission intensity from the lower polariton branch to a manifold of dark states. Through accompanying calculations based on a kinetic model, this shift is rationalized by an entropic trapping of excitations by the dark state manifold, while a weak dark state dispersion due to local disorder explains their non-zero emission. Our results point towards the relevance of the dark state concentration to the optical and dynamical properties of cavity-embedded quantum emitters with ramifications for Bose- Einstein condensate formation, polariton lasing, polariton-based quantum transduction schemes, and polariton chemistry.
Streamlining Lateral Flow Assay (LFA) Data Analysis: A MATLAB® Live Script for Integrated Batch Image Processing and Limit of Detection Determination
Authors: Saxena Karan , Toley Bhushan
Published: March 2024

Lateral flow assays (LFAs) are widely utilized for rapid point-of-care diagnostics in various fields; however, their quantitative image analysis is frequently hindered by repetitive manual processes and inconsistencies, typically involving the use of combinations of image processing and data analysis software tools. This protocol introduces a MATLAB live-script-based code for the integrated batch processing of LFA images and standard curve development. This code simplifies quantitative LFA analysis by automating image processing, peak detection, statistical analysis, and data fitting to a 4-parameter logistic curve for accurate Limit of Detection (LoD) determination. This approach significantly minimizes manual intervention and the potential for human error, thereby enhancing reproducibility. This addresses the critical need for efficient and reliable LFA data analysis in research laboratories. By offering a standardized method for LFA image processing and data analysis, this protocol facilitates faster and more consistent research outcomes.
A REVIEW ON FUTURE PERSPECTIVES IN TARGETING THE RNA CAPPING IN DENGUE VIRUS BY NS5 METHYLTRANSFERASE
Authors: Vashisht Kapil , C. Pandey Kailash
Published: March 2024

Dengue is a clinically important arboviral disease and its global estimated burden is worrisome for the national and international health agencies. The Dengue virus (DENV) NS5 is the largest and most conserved non-structural protein among flaviviruses; for its crucial role in RNA synthesis and capping, it has been explored as a therapeutic target. In this review article, we have discussed the role of RNA capping and how it is critical for the viral RNA stability and evasion from the host immune sensors. With the structural information and mutagenesis studies describing DENV NS5 methyltransferase mechanistic role in sequential methylation, selective inhibitors for methyltransferase (MTase) domain have been identified. Despite, extensive studies, we could find only limited number of inhibitors targeting the capping process in vitro; but no clinically relevant inhibitors have been reported till date, particularly owed to the non-specificity and toxicity issues. In the future perspective section, we propose novel enzyme engineering strategies to develop a therapeutic protein that can be administered in severe Dengue cases to bring down the viral load. The proposed engineered MTase can have characteristics not only limited to enhanced affinity to viral RNA than native MTase and accomplishing defective or non-canonical methylation, that can render the viral RNA unstable or prone to host immune sensors. The engineered MTase can be delivered via state of art delivery systems such as nanoparticles, chimeric proteins, protein cages etc.
COMPARATIVE PHYTOCHEMICAL, MINERAL, PROXIMATE AND ORGANIC COMPOUND STUDY OF FOLIAR EXTRACTS OF CAPSICUM SPECIES WITH THEIR ANTIMICROBIAL POTENTIALS
Authors: O. Adepoju Adeyinka , Roy Macaulay Milson M , O Omotoso Ifeoluwa , G Adewumi Aderiike , A. Osundara Olukemi
Published: March 2024

Capsicum variants are significant spices in traditional diets because they provide nutritional and medicinal benefits and contain high levels of vitamins A and C. Determining the near-term, chemical, biochemical, and antibacterial potentials of foliar extracts of Capsicum annuum and C. chinense is the main goal of this work. The primary goal of this study was to examine the biochemical components of the extracts of Capsicum spp. in relation to their antibacterial potentials. Standard techniques were used to study the proximate and phytochemical analyses of these extracts, and Gas Chromatography-Mass Spectrometry (GCMS) was employed to assess the elemental and organic content of the leaves. By using the disc-diffusion method, the bioactive components and antibacterial efficacy of 7 bacterial and 3 fungus isolates were examined. The biochemical analyses showed that the leaves have a high crude protein content and low dry matter content. Studies on phytochemicals revealed that among the other phytochemicals found, C. annuum and C. chinense were rich in cardiac glycoside but low in tannin. In the extracts of the, it was discovered that Mn, Zn, Cu, Na, K, Mg, Ca, Fe, and P were among the different mineral elements present. There were found to be 16 different organic compounds in all, falling into five different chemical categories: esters, alkanoates, alkanoic acids, alkanols, and alkanes. The methanolic extracts of C. annuum and C. chinense exhibit notable effectiveness against all chosen bacterial and fungal isolates when used at a dosage range. These plant species’ methanolic extracts were discovered to be full of chemical and biological components. As a result, these chemicals’ synergistic actions are anticipated to have positive effects on nutrition and health. Therefore, it is advised to consume a lot of food that contains these components.
PONERINE ANT (HYMENOPTERA: FORMICIDAE) AS VECTORS FOR BACTERIA IN PUBLIC HEALTH CENTRE, MADURAI, TAMIL NADU, INDIA
Authors: Rajagopal Thangavel , Muthukatturaja Marimuthu , Kaliswari Manickam , Selvarani Subbiah , Ponmanickam Ponnirul , Seva rkodiyone Subramanian
Published: March 2024

Ants (Hymenoptera: Formicidae) are a highly sociable and diversified groups of insects found in tropical regions. They coexist harmoniously with humans and are well-adapted to urban environment. Several studies have found that ants can carry pathogenic microbes in their environments and cause infections / spread pathogens. The present study aimed to identify and characterize bacterial biomes presence on the body surface of the Ponerine ant, Leptogenys chinensis, collected from various wards at the Government Rajajii Hospital, Madurai, Tamil Nadu, India. A total of nine bacterial isolates were isolated from the external body surface of the ants, among which 55.55 % were Gram-positive bacilli (Bacillus spp., Corynebacterium sp., and Paenibacillus spp.), 11.11 % were Gram-positive cocci (Staphylococcus sp.) and 33.33 % were Gram-negative bacilli (Pseudomonas spp. and Enterobacter sp.), reportedly in hospitals around the world. The findings of the present investigation, Ponerine ants could carry Gram-positive bacilli, Gram-positive cocci and Gram-negative bacilli bacteria. This emphasizes the significance of ants as mechanical vectors for the spread of pathogens in the hospital environments.
SIMPLE EXTRACTION OF THE HYDROXY-APATITE FROM THE EGYPTIAN NILE TILAPIA (OREOCHROMIS NILOTICAS) FISH SCALES
Authors: Talat Rashad Rama
Published: March 2024

This study aims to recycle the fish scales to extract the hydroxyl-apatite (HApT) compound via a simple and fast chemical treatment of the Egyptian Nile Tilapia (Oreochromis niloticas) fish scales. The method depends on both the NaOH and/or the HCl solutions to dissolve the fish scales then precipitate the HApT 30-32% of the start. The product was characterized by the elemental analysis, Fourier Transform Infrared Spectroscopy (FTIR), X-rays Diffraction (XRD), Field Emission Scanning Microscopy (FESEM), Energy Dispersive X-rays spectroscopy (EDX), and Thermo-Gravimetric Analysis (TGA). The results of the FTIR and XRD have revealed the main peaks of an amorphous/crystalline mixed HApT phase that was almost thermally stable after elimination of the entrapped water of preparation and/or the residual organic portion. The particles have exhibited soft homogeneous morphology rather than specifically shaped particles with a 2.25 Ca/P ratio as indicated by the results of the SEM and EDX analysis. The particle size distribution (PSD) analysis has indicated a range of particle size ~250 – 2500 nm with 50% of sample volume < 1 μm. It can be concluded from the results that the studied method is an efficient and economic approach for the HApT extraction as well as the fish scales recycling.
Efficient transmission of FECG signal using MIMO – OFDM
Authors: Preethi D.
Published: March 2024

The extraction of Fetal Electrocardiogram (FECG) during labor or prenatal phases of pregnancy holds significant importance for early prediction of heart abnormalities. The accuracy of the extracted FECG is crucial for effective diagnosis, but the presence of external noises, particularly from the Maternal ECG (MECG), poses a major challenge in obtaining precise information. To address this issue in biomedical data processing, the study employs Finite Impulse Response (FIR) filters using an array multiplier. One notable challenge encountered in this process is the interference caused by external noises, leading to higher delay and power dissipation. In response, a modified High-Performance Multiplier (HPM) based modified booth multiplier is thoroughly reviewed and validated. This modification aims to enhance overall performance and enable high-speed operations in filtering the FECG signals. The effectiveness of these modified multipliers is assessed using ECG signal information collected from the MIT-BIH Arrhythmia Database, comprising 120 samples. In addition to noise filtering, the study explores the validation of Multiple-Input Multiple-Output Orthogonal Frequency Division Multiplexing (MIMO-OFDM) transceivers. These transceivers play a crucial role in ensuring the effective transmission of the extracted FECG signals. The research reveals a significant reduction, up to 80.4%, in both area and power dissipation during simulations conducted in Xilinx ISE 9.1 and Cadence Virtuoso. This achievement highlights the potential for improved efficiency and reliability in the processing and transmission of FECG signals, paving the way for advancements in early detection of fetal heart abnormalities.
Patrimonios en riesgo: actividades productivas en áreas naturales protegidas. El caso del Parque Nacional El Chico, Hidalgo, México
Authors: Gómez Aiza Adriana , Ortega Meza Daniela , Pulido Silva María Teresa
Published: March 2024

La información histórica del territorio que ocupa el Parque Nacional El Chico (PNECh), en el estado de Hidalgo, México, pone en perspectiva los cambios en los emplazamientos humanos y los usos que ha tenido ese territorio. Se presta especial atención a las actividades económicas que se desarrollaron en la región. Primero la minería, detonante de la fundación de las localidades asentadas en la zona y de la decisión de resguardar los recursos naturales de los bosques circundantes. Desde ese contexto se reflexiona sobre la adopción del ecoturismo como alternativa de desarrollo sostenible para las áreas naturales protegidas. El Chico ejemplifica algunos de los alcances y límites de las políticas ambientales en México.
Gender characteristics of hematuria during lithokinetic therapy in patients with nephrolithiasis
Authors: Barinov E. , Grigoryan Kh. , Yureva A. , Giller D.
Published: March 2024

Purpose. To study gender characteristics of the severity of hematuria and compensatory mechanisms of the proaggregant component of hemostasis in patients with nephrolithiasis when prescribing litokinetic therapy (LCT), including nonsteroidal anti-inflammatory drugs (NSAIDs).
Material and methods. The prospective study included 60 patients (group 1 – 30 men; group 2 – 30 women) with imaging signs of the presence of stones in the urinary tract. For 7 days, patients underwent standard LCT, including NSAIDs, an α1A-blocker (tamsulosin) and antibiotics. In vitro, the activity of the TP receptor for TxA2 and purine P2Y receptors (P2Y1 and P2Y12) was studied on a platelet suspension after 24, 48, 72 hours, 5 and 7 days. Platelet aggregation was assessed using the turbidimetric method using a ChronoLog analyzer (USA).
Results. At the hospitalization stage, in both groups (before the introduction of NSAIDs), hyperreactivity of the TP-receptor was observed, and in men the activity of the TP receptor was lower, and hematuria (p<0.05) was higher than in women. The pharmacokinetics of NSAIDs in men was characterized by inhibition of cyclooxygenase (COX) in two time periods – 72 hours and 7 days, as a result of which the synthesis of TхA2 in platelets decreased and hematuria increased 4.4 times (p<0.001) compared with the hospitalization stage. In women, COX inhibition occurred within 5 days; At the same time, the preservation of normal reactivity of the TP-receptor and purine P2Y receptors ensured the implementation of a compensatory platelet response, limiting the severity of hematuria.
Conclusion. Analysis of the mechanisms of gender differences in hematuria in nephrolithiasis is important for developing a personalized medicine strategy when prescribing NSAIDs.
Pathological anatomy of COVID-19
Authors: Redko A. , Bunga O.
Published: March 2024

The paper provides a review of the literature on pathologoanatomical features of different organs affected by SARS-CoV-2 virus. Signs of necrosis and dystrophy, various circulatory disorders were mainly detected. Morphologic features are not specific for COVID-19; they can also be detected in other systemic infections and shock. This should be taken into account during the pathological autopsy. At the same time, some studies show a connection between SARS-CoV-2 and some diseases with an etiology that is not fully understood, so additional research is required.
UM RELATO DE EXPERIÊNCIA: A PSICOLOGIA HOSPITALAR COMO FORMAÇÃO ACADÊMICA.
Authors: Arouche Raylanne Costa
Published: March 2024

O artigo fala a respeito do que norteou a estagiária de Psicologia na prática externa com a Psicologia hospitalar e perinatal. O artigo se propôs a esclarecer sobre como o psicólogo atua em uma matern
200 Perguntas e resposta sobre suinocultura
Authors: Ferro Diogo Alves da Costa , Ferro Rafael Alves da Costa , Silva Marianne Pereira , Freitas Paulo Vitor Divino Xavier de , Silva Bruna Paula Alvas da , Santos Aracele Pinheiro Pales dos , Santos Kayto José Gonçalves dos
Published: March 2024

A obra e vasta em perguntas e respostas do cotidiano sobre criação de suínos, conta com muitos detalhes e traz a luz ao vasto conhecimento sobre o assuntos, vale ressaltar o desfecho de alguns casos complexos. A suinocultura ou suinicultura é o ramo da Zootecnia que se dedica à criação racional de suínos. Num sistema intensivo, os animais são mantidos em confinamento, e recebem ração balanceada, práticas sanitárias e instalações apropriadas.
The effect of a single cycle of ischemia on bar velocity during bench press exercise
Authors: Bichowska-Paweska Marta , Gawel Dawid , Trybulski Robert , Jarosz Jakub , Losinska Kinga , Fostiak Krzysztof , Vieira Joao Guilherme
Published: March 2024

Introduction: The main goal of this study was to investigate the effects of a single cycle of ischemia applied before the bench press exercise on acute bar velocity changes. Materials and Methods: Twelve physically active males participated in the study. The experiment followed a randomized, cross-over design under two testing conditions. The experimental condition involved the application of a single cycle of ischemia (5 minutes; 80% arterial occlusion pressure [AOP]) before the first set of bench press exercise (2 sets at 60% 1RM). The control condition did not use ischemia. The peak and mean bar velocities were measured using a linear position transducer. Results: Two-way repeated measures ANOVA revealed no statistically significant differences in the peak or mean bar velocity between the ischemia and control conditions both during the first and the second set of the bench press exercise. Conclusions: The results of this study indicate that a single cycle of ischemia applied before the bench press exercise did not influence changes in peak or mean bar velocity.
RECOMMENDATIONS ON THE USE OF OER IN DESIGNING A COURSE
Authors: Tila Dorina
Published: March 2024

The focus of this review paper is to provide data-based recommendations for the use of Open Educational Resources (OERs), which are customised by the lecturer and possibly curated by the students. The use of OER has been advocated mainly because of the cost savings to students, as they are a free or low-cost alternative to traditional textbooks. However, this article also uses students' responses to find new ways of using OERs to enhance student learning in the classroom. Strategies offered are encouraging the use of OERs and curating them to improve student networking through discussion as well as within a student team.