bluuebunny/crossref_metadata_2025 huggingface dataset:
The beaty of Allegorical attribution in the Qur’anic discourse and its rhetorical purposes (A Rhetorical, Descriptive and Analytical Study)
Authors: Nazar Dr. Shabana , Shafiullah Dr. Hafiz , Yousaf Dr. Muhammad Shuaib
Published: September 2022

The Scholars, in this Article, intended to bring to light the cream of folk Literature of “Allegorical attribution(الاسناد المجازي)  in the Qur’anic discourse  and its rhetorical purposes” by prescription and description of its properties and features. The Method followed in this research is " Rhetorical , Descriptive and Analytical Study" The Research is actually an investigated of Stylistic Features of Allegorical attribution . It will inspire readers to get recreated from the World best academic Treasury of Proverbs and Aphorisms having diversified forms. Moreover this Research will also appeal the Scholars who want to make further research in the Stylistic Study of Allegorical attribution. As per our research, we studied all kinds of psychical Metaphor and I explained it with examples in the light of authentic books of rhetoric written by islamic scholars.
An Overview of the Qu’rānīc Concept of “Jahi’liyyah” and Various Trends of the Present Age
Authors: Anjum Samina , Khubaib Dr. Muhammad
Published: September 2022

The system of this universe has been running under the divine commands of Allah Almighty on fixed and unchangeable principles for centuries. These laws of Nature are the sunnah of Allah Almighty or the religion of this Universe. If man violates these natural laws, doing so is to one's own detriment. Ethical laws as the religion of mankind are also made for the benefit of human beings. These rules are indispensable for the accuracy of human interactions to build society on the right foundations protect it from harms and to create a good society in it. Violation of these laws is more harmful than violation of natural laws. Loss of breaking moral rules is not only limited to his own self, but it also affects the other person or more human lives. Ignoring all these principles of the universe man thinks that he can make rules for himself by building his intellect and can run his life as he pleases and can be successful. This baseless thinking of man is due to the interests of the transient life and this is the starting point of his ignorance. Ignorance is actually the name of deviating from the guidance of Allah and rejecting His command. The word used for his condition is “Jahi’liyyah” at every stage of humanity, if the guidance revealed by Allah is turned away, man will suffer ignorance. Allah Almighty has mentioned four different tendencies of ignorance (Jahi’liyyah) in his last book Qu’rān. These are the general tendencies that man has been suffering from in every age when he puts aside the divine guidance. The forms of ignorance described in the Qu’rān are common in our society today. Modern ignorance is a scientific ignorance which is proving to be more dangerous for humanity than the ancient ignorance. The religion of Islam is all knowledge which removes the darkness of ignorance in every age.
Counter Narrative on Extremism and Terrorism in Islamic Perspective and Role of Muslim Thinkers in Establishment of Peace: Analytic Study of Pakistan’s Efforts to combat violent Extremism
Authors: Abbasi Muhammad Umar Riaz
Published: September 2022

Islam is the true religion of peace, reconciliation, and harmony, which primarily deals with the sanctity of human beings without discrimination of religion, creed, and ethnic group. The subject of Divine Commandments is humanity which can be derived from the address of Allah almighty in the Holy Quran "O people' 'The Holy Prophet Muhammad SAWW said, "The best among people who is the source of benefit for the whole humanity". Pakistan has been facing the challenge of extremists and terrorism since 9/11 and has sacrificed thousands of lives in the war on terror. Despite greater securitization, surveillance, examining, and numerous counterterrorism measures, the problem appears to worsen rather than improve. While there may be success stories of terror plans being stopped and radicals being funneled into De-radicalization programs, the tragic reality is that innumerable young people continue to be exposed to extremist propaganda, mainly through social media. In this paper, I have elaborated Islamic perspective on counterterrorism with the help of divine commandments and a rational approach that Universalism and moderation are what Islam stands for. It is a religion of peace, protection, and human rights; there is no room for oppression and injustice in Islam. In the second phase of a research paper, I have analyzed the academic contributions of Muslim Thinkers to encounter extremism and terrorism. I have also highlighted the narrative of the Paigham-I-Pakistan joint declaration of scholars of various schools of thought to create harmony and peace in the country.
Religious and political rights of minorities in constitution of Pakistan and Islamic teachings
Authors: Hussain Bilawal , Ali Khawaja Arshid , Malik Dr. Mussarat
Published: September 2022

Islam is the natural and universal religion that permits every creed of world to enjoy the freedom of their own religion, this is a religion which is for all human beings, free of religious boundaries allowing each of the theology, bent of minds, school of thoughts and people around the world. It is beauty of Islam, who cares especially for Non-Muslims as to fulfill their fundamental rights of their religion and society.  Islam, the religion is a road map of life, wherein Pakistan, the home land of then Muslims of sub-continent, is found by Quaid-e-Azam Muhammad Ali Jinnah in the name of Islam. Muslims are the largest population in Pakistan living with non-Muslims  side by side like Hindus, Budhs, Sikhs, Christians and others. The constitution of Pakistan guards the rights of the minorities in the fields of religio-socio-political rights in the society with greater importance. Religion and politics have  immense role in human life, religion is a way to interact with creator and spiritual satisfaction, whereby politics is a way  to interact and  manage affairs of  people ,In the Islam and constitution of Pakistan minorities are given religious freedom and protection. They may perform their religious customs, they may vote any one and they are given special seats in provincial as well as federal government. In this article  diverse religious and political rights of minorities are brought into the lights of Islam and construction of Pakistan
Characteristics of Mustafa (S.A.W.W) in Archaeology Literature of Sufis
Authors: Rehman Dr. Ammara , Yaqoob Hafiz Sajid
Published: September 2022

The contributions of Sufis have been universally accepted in the promotion and spread of Islam, especially in the awakening of love and obedience for the last Holy Prophet Muhammad (S.A.W.W). Moreover, they have prominent role in developing the concern for here after thereby inculcating piety and enlightening the mind and heart of the Muslims followers. In order to illuminate the hearts of Muslims with the pure spirit of Islam, these scholars not only have delivered speeches but have also struggled in written form. They ensured the chastisement of souls in every possible way. The discussion on different aspects of the life of the Holy Prophet (S.A.W.W) along with various and wide ranged debates on Tasawwuf are quite prominent in the malfuzati literature of these saints if analyzed. For they have presented the life of Holy Prophet (S.A.W.W), in front of the followers, as a perfect model to be followed. They have given special details to the beliefs regarding Holy Prophet (S.A.W.W) describing His ethics, respect and love, specialties and miracles and his rights on his ummah. This article deals with these specialties presented in malfuzati literature.
Tradition of Hamd o Naat in Urdu dastan Starting to 1820
Authors: Abbas Dr. Naseem , Ijaz Dr. Sumaira
Published: September 2022

Urdu Dastan writing was started in 1635 and the first dastan was Subrus by Mullah Wajhi. The tradition of Hamd o Naat in dastan was also started at the same time. Previously, it was strongly traditioned in Urdu Masnavi. This article presents a critical analysis of this tradition from 17th century to first two decades of 19th century. Ata Hussain Tehseen, Shah Alam Sani, Meer Hassan Shah Haqeeqat are the major writers of 18th century. In 19th century, the major contribution to this tradition was made by Fort William College, Calcutta. Haider Bakhsh Haideri, Meer Amman, Sher Ali Afsos, Nehal Chand Lahori, Hafeez ud din Ahmad and Kazim Ali Jawan are the prominent writers of Fort William College and they strengthen end the tradition of Hamd o Naatr in dastan. This article shows that the Urdu Dastaan is the reflection of our religious values in an impressive manner.
Dimension of Al Hadith knowledge in Eight century
Authors: Aslam Dr. Tahir , Ali Dr. Ashfaq , Sohail Dr. Muhammad
Published: September 2022

The saying/ narration of the Holy Prophet Muhammad(PBUH) have been collected and transform as books of Ahdith. The aim and objective of the effort was to conceive the message of Muhammad (PBUH) among the people of his time (Sahaba)and the generation came afterward.8th century witnessed remarkable contribution made by the Islamic intellectuals and writers in promoting and projecting of AL Hadith knowledge.

This article reflects the work in the following fields:
Religious and educational services of Said Nursi: Research Review
Authors: Parveen Dr. Zakra
Published: September 2022

Said Nursi was the prominent scholar of the 20th century. He worked for betterment of Islam. He was in favor of modern education in Turkey that was why he gave his own education system which was the blend of traditional and modern concepts of education. In spite of the resistance of traditional religious scholar, he did not leave his struggle for harmonize the Islam to modern trends. In this article, humble effort is made to highlight his religious and educational services.
Research Review of women’s issues of ghusl in the light of the Narrations of the wives of the Rasool (PBUH)
Authors: Naz Hina , Bano Dr. Najma
Published: September 2022

Purity is called ‘Tahart’ in Arabic Tahart is not only cleanliness but also the purity of  body, soul, clothes and environment. Islam gives guiding principles of life and purity and cleanliness have such a great importance in these principles that it seems as if the religion of Islam is based on them. In Islam particular emphasis is placed on ghusl to achieve purity. Ghusl of Janabah, menstruation, nifas  and istihaza are directly related to men and women. The wives of the Rasool (PBUH) have played unparalleled role in this regard. By putting aside the “shari” shame and modesty, they have shad light on the different types and methods of ghusl. Modern issues related to ghusl such as artificial hair, dentures, nail polish, earring, nosering and prostheses are also mentioned in this article. So that people now a days take care of these things during ghusl and attain complete purity. Because of the imitation of modernism in the modern era, man is moving away from the basic Islamic teachings and is becoming a victim of various physical, mental and psychological confusions. There is a need to spread Islamic teachings about purity and holiness. This article will be useful for the young generation. So that they have awareness and consciousness in this regard.
A Critical Study on the Fundamentals of Masalih and Mafasid’s Attainments in the light of Sharia’s Objectives.
Authors: Hasan Shah Muhammad Mahmood ul , Tayyabi Dr. Anwarullah , Shah Dr. Muhammad Ahmad
Published: September 2022

Islam is a complete code of life and a religion for all humankind. Its injunctions invite humanity to balance their approach towards themselves and all living and non-living things in the universe to preserve the ultimate objective of existence and an opportunity to succeed in the world and the hereafter. Its very commandments lead towards benefits (Masalih) and prevent from harms (Mafasid) in every sphere of life and the afterlife and have a simple purpose to provide comfort peace, respect, justice and most importantly a loving but submissive relationship with Almighty Allah. It’s a daunting task to grasp the actual objectives of Islamic Sharia and the most difficult part is to understand the basic sources and principles of recognitions of Masalih and Mafasid. Ergo, this article deals with the significance of reason and its logical tools to highlight and show the Sharia’s answers of the contemporary issues as well as remaining instruments of identifications of Masalih and Mafasid in the light of the Sharia’s objectives for a successful human life and the betterment of the whole world and the afterworld.
OS HONORÁRIOS PERICIAIS E A ATUAÇÃO DO PERITO JUDICIAL EM CIÊNCIAS RADIOLÓGICAS LEGAIS
Authors: Da Luz Silva Wendell , Siqueira Dias Richard
Published: September 2022

O surgimento das atividades periciais remontam a necessidade do profissional técnico de auxiliar o Poder Judiciário na tomada de decisão. O magistrado não dispõe do conhecimento científico sobre todas as áreas profissionais e, por este motivo, pode nomear um Perito Judicial para que possa esclarecer os fatos do processo. A atuação do Profissional das Técnicas Radiológicas perante o Poder Judiciário possui direta interferência nas demais áreas do radiodiagnóstico, pois, a emissão de laudos e pareceres não se finda nas palavras individuais do profissional que as profere, mas, demonstra o entendimento de uma classe inteira sobre determinado assunto. Sendo necessário a formulação de leis especificamente criadas para delimitar, legitimar, apoiar e organizar a atuação destes profissionais, carecendo da concentração em um único Código Diceológico e Deontológico dos Peritos Judiciais em Ciências Radiológicas Legais.
LONA CLÍNICA: UMA FERRAMENTA PARA O MANEJO DE CASOS CLÍNICOS
Authors: Jonatha dos Santos Ferreira Rubens , Carla Estellita Vogeley Ana , Loísa de Lima e Silva Araújo Ana
Published: September 2022

Propósito: O presente estudo tem como objetivo desenvolver, a partir das ferramentas do Design Thinking e do Business Model Canvas, um recurso visual dinâmico que permite o diálogo sobre insights gerados por toda pesquisa e desempenho clínico para melhorar o gerenciamento de casos clínicos. Método: O modelo diamante duplo foi utilizado como abordagem metodológica para definir o problema. A partir disso, foi possível definir os principais fatores agravantes para o problema, bem como a definição do problema central. Resultados: Como resultado, nove tópicos foram selecionados como pontos-chave para o sucesso na gestão clínica e esses tópicos podem ser personalizados para outras clínicas, pois são padrão na área da saúde. O Clinical Canvas resume as ideias dos líderes no projeto de saúde para permitir que os profissionais de saúde desenvolvam a capacidade de criar seu próprio laboratório ou avaliar criticamente seu desempenho, com base no gerenciamento eficaz de casos clínicos, úteis para o planejamento estratégico e os fins de gestão de casos clínicos que tradicionalmente existem. Para avaliações qualitativas e quantitativas realizadas com cuidadores, será utilizada uma forma digital iterativa. Conclusão: A Tela Clínica sintetiza insights de líderes em design de saúde para permitir que os profissionais de saúde desenvolvam a capacidade de criar seu próprio laboratório ou avaliar criticamente seu desempenho, com base no gerenciamento clínico eficaz de casos clínicos, úteis para fins estratégicos de planejamento e gerenciamento de casos clínicos que tradicionalmente existem.
Mecanismos de resistência ao T-DM1 em pacientes com câncer de mama HER2 positivos: uma revisão sistemática
Authors: Figueiredo Mariana Caetano , Rissetto Nicoli Gueno , Tanaka Rhenan Tolentino , Dombroski Viviane , Cervini Ricardo , Dal Pont Gustavo Colombo , Centa Ariana
Published: September 2022

O trastuzumab-entansina (TDM-1) é um fármaco anticorpo conjugado a drogas (ADCs) utilizado no tratamento direcionado ao câncer de mama HER2-positivo com importante eficácia clínica, porém é percebido em alguns pacientes resistência a esse medicamento, o que se mostrou um obstáculo para o tratamento oncológico. O presente estudo busca conhecer os mecanismos de resistência ao TDM-1 em pacientes com câncer de mama HER2 positivos, encontrados em 6 artigos da literatura, baseando-se em uma revisão sistemática. Foram encontrados dez mecanismos envolvidos na resistência ao TDM-1, sendo eles: expressão diminuída de HER2, dita como forma de resistência em três dos artigos revisados; STAT3 ativados de forma anômala; superexpressão da proteína caveolae; maior ativação da via NRG1/HER3; atividade de efluxo aumentada; expressão do gene SLC; expressão e a fração polimerizada da tubulina B III diminuída; a presença de um número maior de cromossomos; células cancerosas gigantes e aneuploides e a superexpressão do gene YES. Constatou-se, por fim, que conhecer cada um desses mecanismos de resistência é de extrema importância para o desenvolvimento de novas terapias oncológicas.
COVID-19 vaccine’s knowledge, attitude, and perception of healthcare students in India after the second wave of a pandemic
Authors: Sharma Ashaben , Chanan Ritika , Patil Kiran , Dwivedi Shivam
Published: September 2022

Background: The COVID-19 vaccine has been increasingly discussed in India since its first approval in January 2021, prioritizing healthcare workers including healthcare students. Since healthcare students (future healthcare workers) play a vital role in vaccination coverage, this study aimed to assess the knowledge, attitude, and perception toward the COVID-19 vaccine of healthcare students after the second wave of the Pandemic. Method: A web-based questionnaire survey tool was developed, delivered over “Google Forms”, and was filled out randomly among the intended population in many states of India after the COVID-19 pandemic second wave. The questionnaire contained an informed consent form along with questions related to socio-demographics, knowledge, attitude, and perception, toward the COVID-19 vaccine. The data was collected in excel and based on the result we prepared our statistical graphs. Multivariate regression and Bivariate were utilized to identify differences among subgroups with diverse sociodemographic characteristics. Result: Most students had below-average knowledge regarding the COVID-19 vaccine. The highest percentage of correct responses were from postgraduate medical students living in urban areas and the lowest was from undergraduate nursing students living in rural areas.
Study of morbidity, mortality and survival of low birth weight babies born in a tertiary care hospital Vadodara Gujarat
Authors: Patel Maharshi Vinod , Parmar Piyushkumar C. , Somani Abhishek , Bharat Bhavsar S.
Published: September 2022

Introduction: The birth weight of an infant is strongly conditioned by health and nutritional status of mother and is an important determinant of survival, healthy growth and development of the newborn. Low Birth Weight has been defined by World Health Organization as weight at birth of less than 2500 grams. Materials and Methods: 252 babies having birth weight between 2.0 Kg to 2.5 Kg born during August 2012 to January 2013 in Jamnabai Hospital of Vadodara city were included in this prospective study of six month for assessing Survival rate and morbidity among them. Results: All 249 babies (3 drop out), who were followed up 6 months survived. Prevalence rate (sick babies) varied from 17.27 % to 41.2 %, Prevalence rate (Morbidity) varied from 18.07 % to 42.4%. Common morbidities were fever, cough, cold, diarrhea, vomiting, rash. Babies who were fully immunized had lesser morbidity compared to babies who were not fully immunized. Conclusion: The 6 months prospective study which was carried out on small sample of specific group of babies in Urban area has value that it reflects the situation of babies in middle and lower middle class families.
Prevalence of viral hepatitis amongst dental patients attending university dental clinics in Basrah
Authors: Al-Marashi Ahmed Ali , Refaat Majed Mohamed , Haji Sarah
Published: September 2022

Background: Hepatitis is a highly infectious blood-borne disease affecting the population worldwide. The dental team is highly susceptible to acquiring the disease if get injured by contaminated sharp objects. Immunization against hepatitis B became widely obligatory for dental students and dental team members. Materials and Methods: This retrospective study collected data from the university of Basrah dental clinics. Patients attending oral surgery department clinics from January 2021 to December 2021 were screened for Viral Hepatitis B and Viral Hepatitis C by lateral flow test strips. Data were collected and prevalence was calculated. Results: The sample included 561 patients, having 12 patients being excluded for missing information and the remaining 549 were included in the quantitative assessment. The test results for Hepatitis B revealed 5 total prevalence of 0.91%. For the test results for Hepatitis C, there was a total prevalence of 0.73%. Conclusions: The prevalence of Hepatitis B and Hepatitis C are relatively low among dental patients. However, the importance of screening is highly recommended to minimize the risk of transmission.
association of baseline C-reactive protein, D-dimer, and lymphocytes levels with health-related quality of life in severe COVID-19 survivors
Authors: Utami Ida Ayu Ika Wari , Somia I Ketut Agus , Arisanti Ni Luh Putu Eka , Rai Ida Bagus Ngurah , Kusumawardani Ida Ayu Jasminarti Dwi , Candrawati Ni Wayan , Artana I Gusti Ngurah Bagus
Published: September 2022

This study examined the association between baseline inflammatory markers and HrQoL (assessment using the SF-36 instrument) in severe COVID-19 survivors with cross-sectional observational analysis. The total subject is 80 people. Poor HrQoL findings based on the Physical Component Summary (PCS) were seen in 22 individuals (27.5%), and poor HrQoL findings based on the Mental Component Summary (MCS) were seen in 22 individuals (27.5%). The results showed that eight subjects (47.1%) with high D-dimer levels had poor PCS and MCS scores, with the same PR 2.1 (CI 95% 1.069-4.196;p=0.042). High levels of D-dimer and a duration of 12-16 weeks of confirmation were independently associated with PCS values ​​with PR values ​​of 5.5 (95% CI 1.190 – 25.144;p=0.029) and 4.5 (95% CI 1.402 – 14.647; p= 0.012). Meanwhile, a history of not taking routine medication for the treatment of comorbid diseases was a predictor that was independently associated with the MCS value, PR 0.3 (95% CI 0.115 – 0.956; p=0.041). This conclusion is CRP; absolute lymphocyte levels were not associated with HrQoL of severe COVID-19 survivors.
Study of neutrophil to lymphocyte ratio as a prognostic marker in COVID-19 infection-our experience at teritary care hospital
Authors: Reddy A. Smita , Rajakumar K. , Saritha C. , Ravuri Swarupa , Devi B. V. Anuradha , Jestadi Anunayi , Reddy Danda Samyukta , Madhuri K.
Published: September 2022

Background: To evaluate the prognostic value of Neutrophil to lymphocyte ratio (NLR) in Covid -19 patients at our district area hospital/ Teritary care center. Methods: It is a prospective study from 1-8-2021 to 30-9-2021. Patients  who presented with complaints of  Fever, sore throat, body pains, cough, breathlessness, diarrhoea were evaluated at the triage area of the Hospital. Throat swab was taken and RT-PCR was done and only 200 confirmed cases were included in the study. Patient blood samples were collected and processed in SYSMAX 5 -part, Heamotology analyser in the Hospital Central Laboratory. The patients CBP was processed in the laboratory NLR value calculated and tabulated. Results:  Out of 200 cases number of Males were 145(72.5%) more compared to the female were 55(27.5%), with NLR value 1.0-3.9 in74 cases(37%) ,4.0- 6.9 in 63 cases (33%) , 7.0 – 9.9 in 25 cases (12.5%), 10-12.9 in 17 (8.5%) cases , 13-15.9 7 cases(3.5%), 16 -18.9 3 cases(1.5%) ,19-21.9 9 cases(4.5%) ,22-24.9 0 cases, 25-27.9 0 cases , 28-30.9 2 cases ( 1%). Conclusion: NLR Value more than 3.5 found to be significant and it is correlating with the patients symptoms.
Assessment of vitamin D status in rheumatoid arthritis patients
Authors: Malhotra Neeraj Kumar , Waraich Harsimrat Singh , Khatri Kavin
Published: September 2022

Background: Vitamin D is a secosteroid hormone involved in bone and calcium metabolism. It is involved in the regulation of calcium homeostasis, as it regulates calcium absorption from the gastrointestinal system. The present study was conducted to assess vitamin D status in RA patients. Materials & Methods: 112 Rheumatoid arthritis patients of both genders were put in group I. Healthy subjects were also enrolled and put in group II. Disease activity score of RA patients was calculated. Disease severity was assessed according to the value of DAS28 score as follows- Remission: DAS28 ≤2.6 Low disease activity: 2.6 5.1. 25 (OH)-Vitamin D Xpress ELISA Kit was used for the quantitative measurement of Vitamin D3 {25 (OH)-D3} in serum. Results: Group I had 62 males and 50 females and group II had 70 males and 42 females. Disease activity was remission, low, moderate and high with mean serum calcium level (mg/dl) as 8.92, 8.34, 8.22 and 8.01 and vitamin D (mg/dl) as 35.6, 31.4, 22.3 and 14.8 respectively.
Prediction of deleterious non-synonymous SNPs of human TLR2 gene associated with bacterial meningitis and hearing impairment by computational approach
Authors: Manikandan Palanisamy
Published: September 2022

Background: Bacterial meningitis is the most serious infection of the central nervous system and often occurs in children under the age of 5 years and leads to hearing loss, learning disabilities. Several studies have reported the genetic variation in a gene that is involved in the innate immune system and affects the susceptibility, severity of bacterial infection during meningitis. Methodology: Hence the present study was performed to insights the single nucleotide polymorphisms in pathogen recognition genes especially those that play an essential role in the innate immune system. Toll-like receptor 2 (TLR2) was selected to analyze the association of TLR2 in bacterial meningitis. The coding and non-coding SNPs of the human TLR2 gene was retrieved from the NCBI database and were subjected to various computational prediction tools including SIFT, PolyPhen-2, Imutnat, to predict the high-risk deleterious SNPs and the effect of single amino acid substitutions and structural and functional impact of these mutations was predicted with project HOPE, SNP-GO tools. Results: The result revealed that among the 501 non-synonymous, 9 deleterious SNPs were sorted by SFIT, Polyphen-2 and I mutant serve with SFIT score, DDG score, and PISC score which are equal to 1.
A study on sarcoidosis with clinical profile, diagnosis and treatment
Authors: Venksteswararao K. , Raviraju T. , Addepalli Syam Kumar
Published: September 2022

Background: Sarcoidosis is a multisystem granulomatous disease of unknown etiology and a close mimic of Tuberculosis in TB endemic are as which poses a diagnostic challenge. Objective: The main objective of the study is to determine the prevalence of Sarcoidosis with respect to its clinical profile, diagnosis and treatment. Methodology: The present study is a descriptive study with20 documented cases of Sarcoidosis from South India; the study span was from 2011 to 2021with Particular reference to cardiac and other organ involvement. Results: The results showed pulmonary involvement in 100% of patients followed by peripheral Lymph nodal involvement in 70% of patients which offered easy and cost effective diagnosis .Cardiac involvement was noted in 15% of patients as against scarce case reports from India. Ocular and Cutaneous involvement was seen in 15% of patients each. Kidneys and Parotids were involved in 5% of Patients. It should be suspected in any patient with appropriate clinical/radiological findings and the diagnosis of non-caseating granuloma should be made from an easily accessible peripheral site, followed by bronchoscopic and other methods. It should be differentiated from Tuberculosis and other granulomatous lesions. It is a steroid responsive condition and carries good prognosis.
Comparison of the dynamic HIP screw to PFN (proximal femoral nail) for unstable peri trochanteric femur fracture
Authors: Gupta Anuraag Ghanshyamdas , Raghuwanshi Gajendrasingh Ranjitsingh , Adhikari Archit Ajit , Jadhao Amit Bansilal
Published: September 2022

Introduction: One of the most common fractures in the elderly is inter-trochanteric fractures where surgical management allows better functional and rehabilitation outcomes making it a treatment of choice. Aim: To compare radiological, functional, and clinical outcomes following treatment of unstable intertrochanteric femur fractures using dynamic hip screw (DHS) or proximal femur nail (PFN). Methods: The study assessed 120 subjects with unstable intertrochanteric femur fractures where 60 were treated with DHS and the other 60 with PFN. For assessment of the outcomes, Harris hip scores were used. Results: Most surgeries were done in 56-70 minutes in 30% (n=18) subjects and 37% (n=22) subjects in DHS and PFN group respectively which was statistically non-significant with p=0.86. Most common complication was lateral cortex shattering in 16.6% (n=10) study subjects followed by ill-fitting jig in 13.3% (n=8) study subjects and distal locking difficulty in 10% (n=6) study subjects respectively. Mean Harris hip score was higher in PFN group (83.5±2.38) compared to DHS group (82.1±2.32).
A paediatric English linguistics intervention on spoken language for English-speaking parents of deaf children having hearing problems
Authors: Al Anazi Nawaf , Sajid Muhammad Khalid Mehmood , Aljarrah Khaled , Iqbal Zafar
Published: September 2022

Background: This research aimed to find internet information about hearing loss, hearing technology, and spoken language acquisition for Pakistani English-speaking families of deaf or hard-of-hearing children (DHH). Methods: The existence or lack of parent education material on various websites was investigated using an exploratory, descriptive methodology. The research looked at the many Internet resources available. Results: Many websites with information for parents of DHH children acquiring spoken communication were found to be international. Each website was examined in fifteen different content categories. These websites featured English content. According to the present research findings, internet resources for Pakistani English-speaking parents with DHH students struggling with spoken dialect are typically less and less and not deeply involved. Conclusion: A Paediatric English Linguistics Mediation on Spoken Language for Parents of Deaf Children with Hearing Problems in Pakistani English internet alternatives for Pakistani English-speaking parents of DHH children who are having difficulty with spoken dialect are becoming fewer and more uninvolved.
HUBUNGAN TINGKAT KECEMASAN DAN SIKAP MAHASISWA STIKES INTAN MARTAPURA DENGAN LEARNING FROM HOME DI MASA PANDEMI COVID-19 TAHUN 2021
Authors: Hairina Lestari Devi
Published: September 2022

Pendahuluan: Pemerintah Indonesia pertama kali memvalidasi kasus Covid-19 pada bulan Maret 2020 dan semenjak itu pemerintah Indonesia memberlakukan aturan untuk tinggal di rumah dan meniadakan sementara kegiatan di luar rumah seperti perkuliahan. Aturan pemerintah untuk melakukan pendidikan dari rumah membuat sebagian mahasiswa merasa khawatir dan tertekan karena harus mengikuti pendidikan secara online. Tujuan: Penelitian ini bertujuan untuk mengetahui korelasi kecemasan dan sikap mahasiswa saat menjalani learning from home. Metode: Desain penelitian ini menggunakan korelasi dengan rancangan cross sectional, teknik sampling yang digunakan ialah total sampling dengan jumlah responden sebanyak 68 mahasiswa. Hasil: Uji korelasi dengan menggunakan Uji Spearman’s Rho diperoleh nilai signifikan 0,48 yang menunjukan bahwa kolerasi cukup (0,26-0,50) antara hubungan tingkat kecemasan dan sikap mahasiswa dengan learning from home. Kesimpulan: Ada hubungan antara tingkat kecemasan dan sikap mahasiswa dengan learning from home. Saran: Peneliti selanjutnya sebaiknya meneliti tentang faktor-faktor lain yang dapat menyebabkan terjadinya kecemasan saat learning from home.
Taxonomic revision of the Australian native bee subgenus Callalictus (Hymenoptera: Halictidae: Halictini: genus Lasioglossum)
Authors:   Museums Victoria, Walker Kenneth L.
Published: September 2022

The Australian Lasioglossum Curtis 1833 subgenus Callalictus Michener 1965 is revised. Of the eight available names listed by Michener (1965), four are placed in synonymy and one species is recombined into Lasioglossum (Austrevylaeus Michener 1965) providing three valid species for the subgenus Callalictus. New synonymies and valid and recombined names proposed for Lasioglossum (Callalictus) are as follows: Lasioglossum (Callalictus) tooloomense (Cockerell 1929a) syn. nov. = Lasioglossum (Callalictus) aurantiacum (Cockerell 1916); Lasioglossum (Callalictus) ruficolle (Friese 1924) syn. nov., Lasioglossum (Callalictus) rufocollare (Cockerell 1930) syn. nov. and Lasioglossum (Callalictus) anomalum (Rayment 1935) syn. nov. = Lasioglossum (Callalictus) callomelittinum (Cockerell 1910); Lasioglossum (Callalictus) musgravei (Cockerell 1929b) is valid; and, Lasioglossum (Callalictus) contaminatum (Cockerell, 1929b) comb. nov. is moved to Lasioglossum (Austrevylaeus) contaminatum. Males of two Callalictus species have highly modified fore and mid tarsal segments. All valid species are redescribed, and keys to both sexes, montaged diagnostic images and distribution maps are provided to assist with species identifications.
Application Of The Concept Of Singular Value Decomposition For The Making Of Watermark In Documents
Authors: Sinurat Sinar , Edward R Siagian
Published: September 2022

Watermark is a part of steganography that is used by many users in electronic and non-electronic documents. Watermark certainly does not guarantee the safe use or modification of the document, but only the legitimacy of ownership of the document. Watermarking is a part of steganography that is used by many users in electronic and non-electronic documents. Watermarking certainly does not guarantee the safe use or modification of the document, but only the legitimacy of ownership of the document. Establishing a digital watermark will improve the owner's document security. Hiding a label by inserting datum bits in the image segment using Singular Value Decomposition (SVD), as a part of Watermarking. Watermark domains are digital documents in the form of videos, images, text, sound. Watermarking applications built by applying singular value decomposition to numbers
Harnessing the BOP Ecosystems of China and India for Competitive Advantage
Authors: Cheung Mee-Shew , Krishnan Hema , Lee Mina
Published: September 2022

Sustainable development of the base-of-the-pyramid (BOP) is a critical issue in a global society. This study provides an ecosystem framework to develop the BOP segment, particularly in China and India. The BOP segment is the low-income household, mainly residing in rural areas. Traditionally, the BOP segment has been understood as a customer segment. We suggest that the BOP can be suppliers, employees, entrepreneurs, and customers. In other words, a BOP venture exists within an ecosystem and contributes to the ecosystem. This ecosystem includes shareholders, governments, the general public, communities, competitors, non-governmental organizations, special interest groups, employees, supply chain partners, and customers. Specifically, we explain how the BOP can play multiple roles, using the context of the fast-moving consumer goods (FMCG) industry in China and the telecommunications industry in India. To mitigate inequality within nations and enhance the standard of living, governments should also nurture the BOP ecosystem. This framework is applicable in other parts of the world.
Invitro Study on the Combined Effects of Natural Ingredients and Antimicrobial Drugs as Novel Anti Biofilm Approach
Authors: Kehkashan . , Ashraf Aqeela , Chaudhry Afeefa , Yasmeen Roheela
Published: September 2022

Biofilm forming bacteria stick to one another or to the different surfaces or interface. Biofilm formation is not a good thing in many ways as they go with low metabolic rate and passed with less number of cell divisions. Objective: To find some novel anti-biofilm approaches against biofilms. Methods: Soil and water samples were collected from four sites. Soil samples were collected from agricultural land and road side of Hudiara village, Lahore, Pakistan. However, water samples were collected from BRB canal which is situated in village Barki and from tube well of village Hudiara located in Lahore district Punjab, Pakistan. For biochemical identification of isolates different types of biochemical tests such as MR, VP, SIM (motility), H2S, catalase, Indole and nitrate reduction were performed. Results: Some antibiotics and their combinations with different other antibiotics were checked and it was noticed the overall effects of antibiotics on bacterial biofilms have positive effects except disprin and Levofloxacin. While, Ciprofloxacin was found as an effective antibiotic. Combination of ciprofloxacin and disprin was used in order to remove the biofilm and it worked well to remove the biofilm. Conclusions: Different antimicrobial medications, all-natural compounds, and combinations of various antibiotics, including ciprofloxacin-disprin, clarithromycin-moxifloxacin, and certain all-natural ingredients like honey, ginger, and lemon juice, were utilized to remove bacterial biofilms. Thus, it can be said that most of the combinations produced better biofilm removal outcomes than the individual elements did.
Receptor Tyrosine Kinases Mediated Cell Signalling Pathways
Authors: Jawad Ahmad Fridoon
Published: September 2022

A small number of signalling pathways, including receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCRs), are activated by plasma membrane receptors in order for cells to respond to external cues. In addition to transmitting, these pathways also process, encode, and integrate both internal and external signals. In recent years, it has become clear that different spatio-temporal activation profiles of the same set of signalling proteins lead to different gene-expression patterns and various physiological responses. These findings suggest that the precise temporal control and relative spatial distribution of activated signal transducers are necessary for important cellular decisions such as cytoskeletal reorganisation, cell-cycle checkpoints, and cell death (apoptosis). Due to their crucial function in the control of embryogenesis, cell survival, motility, proliferation, differentiation, glucose metabolism, and apoptosis, RTK-mediated signalling pathways have drawn a lot of attention from scientists.
A significant number of serious human diseases, including diabetes, cancer, chronic inflammatory syndromes, and developmental defects, are caused by RTK signalling dysfunction. RTKs undergo allosteric transitions (the insulin receptor, for instance) or dimerization in response to stimulation, which activates the intrinsic tyrosine-kinase activity. Numerous cytoplasmic proteins receive a biochemical signal from subsequent phosphorylation of numerous tyrosine residues on the receptor, which causes them to move to the cell surface. Through intricate biochemical circuits of protein-protein interactions and covalent modification cascades, the resulting cellular reactions take place.
The earlier theories of discrete linear pathways, which connected extracellular signals to the expression of particular genes, have been replaced by an emerging picture of interconnected signalling networks, raising concerns about the specificity of signal-response events. In actuality, all RTK-mediated pathways share a common protein complement that mediates signal transduction downstream of RTKs. The expression of nuclear transcription factors is induced by the activation of kinase and phosphatase cascades, such as the mitogen-activated protein kinase (MAPK) cascades, which are both activated by GPCRs and RTKs. There is no single protein or gene that determines the specificity of a signal for any given receptor pathway.
Instead, the temporal and spatial dynamics of the components of downstream signalling control specificity. A classic example is the distinctive biological response to EGF and nerve growth factor stimulation of PC12 cell lines (NGF). Cell proliferation is temporarily induced by EGF, whereas cell differentiation is temporarily triggered by sustained MAPK activation by NGF. However, there are many variables that affect how MAPK cascades behave. Depending heavily on their subcellular localization and their recruitment to scaffold proteins, MAPK cascades can produce oscillations, abrupt switches, bistable dynamics.
Hypogonadism in Benign Prostate Hyperplasia: A Cross Sectional Study
Authors: Khan Ismail , Aftab Younus Malik , Shoaib Mohammad , Haris Muhammad , Ullah Wazir Noman , Jehangir Khan Muhammad , Haris Sobia , Deeba Farah
Published: September 2022

Benign prostatic hyperplasia is a common health problem affecting men older than 50 years. It is estimated that 30 million men have benign prostatic hyperplasia related clinical features Objective: The objective of this study was to find out the relationship between hypogonadism in patients presenting with benign prostate hyperplasia at tertiary care center. Methods: A descriptive cross-sectional study conducted at Urology Department Lady Reading Hospital Peshawar for a period of one year from June 2019 to May 2020. A total of 361 patients with benign prostate hyperplasia were studied. The sampling technique was consecutive non probability sampling and WHO sample size calculator was used for sample size determination. Serum testosterone level was done all patients as per inclusion criteria. All the data was analyzed in SPSS version 20.0. Results: The mean age, height weight, BMI and testosterone level of qualitative variables were 56.42±10.05, 167.54±9.97, 64.96±12.92, 23.07±4.96 and 15.36±6.36 respectively. The testosterone level decreased with ageing in different age groups. 29.6% patients of our study were 50-59 years old. The hypertensive and diabetic patients with BPH were 31.3% and 22.4% respectively. Out of 361 patients 67 were hypo gonadal men making 18.6%. The hypogonadism had statistically significant mean values of serum testosterone level (p<0.001). Conclusions: This study concluded on the analytical findings that hypogonadism is significantly associated with benign prostate hyperplasia. The testosterone levels decrease with the increase of age and thus patients with low testosterones are more prone to develop benign prostate hyperplasia.
Effect of Specific Stabilization Exercise Along with Muscle Relaxation Technique to Treat Lumbopelvic Pain During Pregnancy
Authors: Shafiq Bushra , Javaid Hina , Mehmood Sajid , Mahmood Anam , Pervez Maria
Published: September 2022

Pain in lower back area amid pregnancy is a typical gripe among women frequently viewed as an inescapable disadvantage of an ordinary Pregnancy. Spinal Specific Stabilizing Exercises and Progressive Muscle Relaxation Techniques are popular form of physiotherapy management in preventing lumbopelvic pain that limits the activities of daily living in patients during and after gestation period. These Specific Stabilization Exercises strengthen Abdominal and Para spinal muscles, which control Lumbopelvic stability Objective: To compare the effects of Specific Stabilizing Exercises and Specific Stabilizing Exercises along with Progressive Muscle Relaxation Technique in prevention and management of Lumbopelvic Pain during pregnancy. Methods: 30 women were randomized to six-week workout plan comprising both Particular workout for stabilization and Progressive Muscle Relaxation Techniques in experimental group and 30 were randomized as control group including only the Specific Stabilizing Exercises. Lumbopelvic torment was evaluated on Visual Analog Scale (VAS) of torment force. Results:  The control and the experimental group were comparable at baseline. The experimental group receiving both exercises showed significant improvement in intensity of perceived pain (p = 0.002) at the termination of 6 weeks’ treatment plan in comparison to control group receiving only specific stabilization exercise Conclusion:  Specific Stabilizing Exercises along with Progressive Muscle Relaxation Technique reduced pain significantly in pregnant women with lumbar and pelvic girdle pain.
Incidence of Occult Inguinal Hernia Diagnosed with Ultrasound in Patients with Groin Pain
Authors: Hashim Muhammad , Uzair Muhammad , Yousaf Farooq Syed Muhammad , Arslan Haider Muhammad , Hanif Babar , Iman Zahra Syeda , Esha Ali Hafiza Iman , Zahid Warda , Jamil Ramesha , Hashmi Seemal
Published: September 2022

Inguinal Hernia is one of the most common problems affecting the population coming with groin pain. Objective: To find the incidence of occult inguinal hernia diagnosed with ultrasound in patients with groin pain. Methods: Descriptive study was conducted at Gilani Ultrasound Centre. Data of 200 participants were designated done with suitable sample method. Data were analyzed by SSPS version 24.0. Results:  Out of 200 male patients the Mean Age ± SD ratio is 23.1±15.7. 38(19%) patients presented with pain bilaterally, left sided pain was presented in 43(21.5%) patients and right sided pain was presented in 119(59.5%) patients. In 25(12.5%) patients occult inguinal hernia was detected and in 175(87.5%) patients occult inguinal hernia was not detected. In 2(1%) patients occult inguinal hernia was detected bilaterally, in 6(3%) patients occult inguinal hernia was detected on left side and in 17(8.5%) patients it was detected on right side. The mean size of the defect on right side was 2.24 and on left side was 5.0. Conclusions: Study concluded that occult inguinal hernia detected in 12.5% patients and majority of them were young adults. Due to the sensitive nature of groin ultrasound, patients may be referred for it if the results of the clinical examination are inconclusive or negative.
Comparing Effectiveness of Median Nerve Mobilization with and without Transverse Carpal Ligament Stretching in Patients with Carpal Tunnel Syndrome
Authors: Shabbir Sidrah , Rasheed Ayesha , Ayyaz Asma , Rasheed Yumna , Saleem Amna
Published: September 2022

Carpal tunnel is the narrow space which is present between smaller bones of hand and an important ligament of hand which is called transverse carpal ligament. Compression of median nerve occurs commonly at wrist which results in Carpal Tunnel Syndrome (CTS). Objective: To compare effectiveness of median nerve mobilization with and without transverse carpal ligament stretching in patients with carpal tunnel syndrome. Methods: In this study, 34 patients were randomly assigned into one of two groups, each with 17 individuals. For two weeks, group B received a combination therapy strategy of Neurodynamics and transverse carpal ligament stretching, while group A only received neurodynamics. After two weeks, there was an improvement in functioning and pain. The DASH questioner and VAS were filled at baseline. The current RCT was conducted at the Akhtar Saeed Trust Hospital in Lahore. SPSS was used to conduct the analysis. Results: In the present study of 34 patients independent sample t test was applied as the mean difference was less in group B, which used a combination treatment method of transverse carpal ligament stretching and neurodynamics, compared to group A, which used only neurodynamics. The p value is less than 0.05, indicating that the results were significant. In comparison to group A, results of group B in which combined treatment approach was applied found to be more substantial and superior. Conclusions: Group B, which included both neurodynamics and transverse carpal ligament stretching, was shown to be more effective than group A, which solely used neurodynamics.