Assessment of Coronary Artery Distensibility by Intravascular Ultrasound
Authors: Nakatani Satoshi , Yamagishi Masakazu , Tamai Jun , Goto Yoichi , Umeno Tetsuhiro , Kawaguchi Akito , Yutani Chikao , Miyatake Kunio 
Published: June 2012

Background
Atherosclerotic change in the coronary artery is associated with an impaired vessel wall distensibility. However, there are few data regarding the relation between vessel wall morphology and distensibility. Therefore, with intravascular ultrasound, we assessed coronary artery distensibility in angiographically normal coronary segments of humans.

Methods and Results
Data were analyzed at 35 angiographically normal coronary sites where circumferential or noncircumferential lesions were demonstrated by ultrasound in 22 patients (mean age, 55 years). After intracoronary injection of 500 μg nitroglycerin (NTG), coronary luminal area was measured with intravascular ultrasound (30 MHz, 3.5F to 4.3F, 1800 rpm). Intracoronary pressure was simultaneously measured with a 2F micromanometer-tipped catheter located at the left main coronary artery. The coronary distensibility index was calculated as 10-fold the ratio of luminal area change to intracoronary pressure change during a cardiac cycle. Another pressure-independent vascular stiffness index, β, was derived by the following formula: β=[ln(SBP/DBP)]/(dD/diastolic mean diameter), where SBP is systolic intracoronary pressure, DBP is diastolic intracoronary pressure, and dD is the difference between systolic and diastolic diameters. At the sites where luminal areas were measured, thickness of intima-media complex, defined as the distance between the intimal leading edge and the adventitial leading edge, was determined as an index of the severity of atherosclerosis. In seven segments, distensibility index was determined before and after NTG injection to examine the effect of NTG on coronary distensibility. In all examined sites, including circumferential and noncircumferential lesions, the luminal area was 12.6±5.0 mm
2
during systole and 11.6±4.6 mm
2
during diastole, and the calculated coronary distensibility index ranged from 0 to 0.83 mm
2
/mm Hg. The thickness of the intima-media complex ranged from 0.12 to 1.30 mm, suggesting the presence of various grades of atherosclerosis even in the absence of angiographic lesions. There was a poor inverse correlation between thickness of the intima-media complex and distensibility index (
r
=.19,
y
=−0.17
x
+0.41,
P
=.29). However, when noncircumferential lesions were excluded for evaluation, there was a significant inverse correlation between them (
r
=.58,
y
=−0.50
x
+0.72,
P
<.01). Under these conditions, the thickness of the intima-media complex also correlated with the value of β (×10
−1
), which ranged from 0.28 to 3.99 (
r
=.70). After NTG injection, coronary distensibility increased by an average of 71% in the segments with a thin intima-media complex, whereas it did not substantially change in those with a relatively thick intima-media complex.

Conclusions
These results suggest that coronary distensibility is impaired in the coronary sites accompanying occult atherosclerosis, none of which can be detected by the conventional angiography. NTG can augment coronary distensibility in the segments without a markedly thickened intima-media complex. We suggest that thickness of the intima-media complex can contribute to determining the coronary distensibility in clinical settings.