bluuebunny/crossref_metadata_2025 huggingface dataset:
Paravasal Connective Tissue Parameters Vs. Morpho-Functional Indicators In The Intraorgan Blood Vessels Of The Younger Men Lungs
Authors: Nickel Victoria V. , Efremova Vlada P.
Published: October 2021

Objective — The objective of this research was to identify correlations between the paravasal components connective tissue of the blood vessels of lungs and their morpho-functional parameters. Material and Methods — In order to determine the structure of the paravasal connective tissue, the histotopographic and histological examination of lung preparations of 20 men corpses of the first mature age period was held, to determine the capacity and capacitive characteristics of the vascular bed, the determination of the Kernogan index (IK) and the veno-arterial index (VAI) were carried out. Results — It was ascertained that in the structure of the paravasal connective tissue two layers could be conditionally distinguished – the "central" and "peripheral", differing in the architectonics of the fibrous component, the nature of interaction with nearby anatomical structures. It was also revealed that infrared venous vessels IK was expressed in a greater degree in comparison with arterial. When determining VAI vascular, the channel revealed that the area of venous vessels prevailed over the arterial area. Besides, the clear correlation relationships of the structural elements of the paravasal connective tissues were investigated with arterial and venous vessel capacity values and their capacitive characteristics. Conclusion — The presence of correlation relationships confirmed a clear interaction between structural organization of the paravasal connective tissue and the functional activity of the blood vessels, providing optimal hemodynamic conditions in the organ.
Job Satisfaction Among Pharmacists
Authors: Smolina Viktoriya A. , Novokreshchenova Irina G. , Novokreshchenov Igor V.
Published: October 2021

Job satisfaction among pharmacists affects the quality of pharmaceutical care and patient health. Our study targeted the evaluation of job and salary satisfaction levels in pharmacists and the factors affecting these levels. Methods — We conducted the survey of 407 pharmacists working at community pharmacies in Saratov Oblast (Russia). Results — The proportions of pharmacists satisfied with their jobs and their salaries were 77.1±0.4% and 52.8±0.4%, respectively. We discovered that salary satisfaction was influenced primarily by the household composition (p=0.004) and professional commitment (p<0.001). Pharmacists who were more satisfied with their jobs belonged to the age category ‘up to 44 years’ (p=0.002). They were less likely to change their employment (p<0.001) and more likely to experience positive emotions when performing their professional activities (p<0.001). Also, they were more satisfied with their salaries (p<0.001), committed to their profession (p<0.001), and more likely to perceive the social importance of their profession (p<0.001). Conclusion — Our findings suggested that formal traits of pharmaceutical professionals had a smaller impact on their job satisfaction, while the greatest impact was caused by the personal characteristics (perception of the social importance of their profession, professional commitment), salary satisfaction, age and frequency of changing jobs.
Features Of Anxiety And Attention In Elementary School Students Of The Russian North
Authors: Bartosh Olga P. , Bartosh Tatiana P. , Mychko Marina V.
Published: October 2021

A child’s body in the contemporary educational process with innovative programs and electronic devices, along with insufficient motor activity, against the background of low reserve capacity in the North, experiences the psychoemotional stress. The objective of our study was to investigate the anxiety and attention in elementary school students in the northern cities of Magadan Oblast. The study was conducted on elementary school students (9.9±0.05 years of age) in the regional center of Magadan and the remote town of Magadan Oblast, Susuman. Group I consisted of 108 Magadan school students, whereas Group II included 82 Susuman school students. Methods — we used the methodology of multidimensional assessment of childhood anxiety (MACA). To investigate the function of attention, we used the method of proofreading modified by V.N. Amatuni. Results — the number of anxious children was 42% in Magadan and 26% in Susuman. Magadan children were significantly more anxious than their Susuman peers on five of ten scales: in connection with the evaluation by others (M±SE: p=0.013; Me [Q1; Q3]: p<0.05); in their relationships with teachers (p=0.003; p<0.01); in terms of their learning success (p=0.016; p<0.05); in situations of knowledge testing (p=0.022; p<0.05); and they also exhibited an increase in their autonomic reactivity associated with anxiety (p=0.040; p<0.05). It was revealed as well that the neurodynamic characteristics of attention were better in the group of Susuman children. Conclusion — It can be assumed that elementary school students in small remote towns are less at risk of school maladjustment and are more efficient than their peers living in larger cities, where anxiety is higher, which complicates the learning process.
Competitiveness and cohesion in Romania's regional development: a territorial approach
Authors: Mitrică Bianca , Săgeată Radu , Mocanu Irena , Grigorescu Ines , Dumitraşcu Monica
Published: October 2021

The assessment of the socio-economic disparities at the regional level is one of the priority development topics. In particular, in formerly socialistic-planned countries, the development driven by the transition period, the accession to the European Union and the economic crisis, the regional disparities are present. The main aim of the research has been to identify the most competitive and the most cohesive Development Regions in Romania by computing, mapping and analysing two secondary indices (Territorial Competitiveness and Territorial Cohesion). Overall, the investigation shows that economic performance is more consolidated in central and western regions based on their mature and innovative industries, better-developed services and urbanisation/suburbanisation processes, while the eastern and southern development regions, with predominantly rural traits, experienced a significant industrial decline and social deprivation. The most competitive Development Region is Bucharest-Ilfov, given the advantage conferred by Bucharest Capital City, the main economic and social polarising centre in Romania. For reducing regional disparities, the Cohesion Policy should allocate increased funds for countries with least developed regions. The study provides the result of quantitative and qualitative analysis on the regional-level territorial disparities in Romania that could easily be considered as guidelines in the decision-making process while trying to achieve the competitiveness and cohesion goals.
Effect of Ultrasonic Assisted on The Degree of Deacetylation of Chitosan Extracted from Portunus Pelagicus
Authors: Buanasari Buanasari , Sugiyo Warlan , Rustaman Heri
Published: October 2021

The technology for extracting chitin from shell and other materials needs to be continuously improved, including its conversion to chitosan. Chitosan is a biocompatible polymer, biodegradable, non-toxic, water-soluble at pH below 6.5, and it has protonated amino groups. The benefits of chitosan in industry, food and medicine make it necessary to fully study an efficient chitosan synthesis method and the results can be applied on an industrial scale. This study examined the effect of ultrasonic-assisted in increasing the degree of deacetylation of chitosan produced from Portunus pelagicus shell waste. The production process of chitosan goes through the stages of deproteination, demineralization and deacetylation. All these steps are ultrasound assisted processes with a frequency of 40 kHz through a digital ultrasonic cleaner. Ultrasonic-assisted chitin and chitosan were examined using FTIR spectrometry. The results showed that the ultrasonic method was able to increase the deacetylation degree of chitin with a value of 68.45±0.11% compared to 62.52±0.08% without ultrasonic. Application of ultrasonic assisted deacetylation gave a deacetylation degree of 85.35 ± 0.20%, higher than without ultrasonic 80.24 ± 0.19%.  Physically, ultrasonic-assisted chitosan is smoother and brighter in color. The ultrasonic-assisted chitosan manufacturing method could increase the deacetylation degree and produce high grade chitosan.
Early Marriage Problems in Indonesia
Authors: Angkasa Aghnat Bintang
Published: October 2021

Marriage in Indonesia is based or regulated in Act No. 1 of 1974 concerning Marriage. In Chapter 2, article 7, paragraph 1 reads "Marriage is only permitted if the man has reached the age of 19 (nineteen) years and the woman has reached the age of 16 (sixteen) years". In this paper I will discuss about marriage at a young age or what we are familiar with the term early marriage. The main factor of early marriage is the role of parents in family communication. In this study it is hoped that the community in particular the parents (family) can increase the support and care for the teenagers to be better in the future.
Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience
Authors: Liu Yuan , Guo Siyi , Wu Jinsong , Wang Rongai , Liu Jinbo , Liu Yan , Lv Bin , Liu Nan , Jiang Ling , Zhang Xiaoli
Published: October 2021

The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n  = 152) and 2017–2021 (group B, n  = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-female ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in group B. Moreover, patients in group B showed significantly lower serum calcium, alkaline phosphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also milder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years.
Extreme hyponatraemia due to primary polydipsia and quetiapine-induced SIAD
Authors: Mc Donald Darran , Mc Donnell Tara , Crowley Rachel Katherine , Brosnan Elizabeth
Published: October 2021

Hyponatraemia is the most common electrolyte disturbance in hospitalised patients and is associated with numerous adverse outcomes. Patients with schizophrenia are particularly susceptible to hyponatraemia, in part due to the close association between this condition and primary polydipsia. We report the case of a 57-year-old woman with schizophrenia and primary polydipsia who was receiving inpatient psychiatric care. She became increasingly confused, had multiple episodes of vomiting, and collapsed 1 week after being commenced on quetiapine 300 mg. On examination, she was hypertensive and her Glasgow coma scale was nine. She had a fixed gaze palsy and a rigid, flexed posture. Investigations revealed extreme hyponatraemia with a serum sodium of 97 mmol/L. A CT brain demonstrated diffused cerebral oedema with sulcal and ventricular effacement. A urine sodium and serum osmolality were consistent with SIAD, which was stimulated by the introduction of quetiapine. The antidiuretic effect of vasopressin limited the kidney’s ability to excrete free water in response to the patients' excessive water intake, resulting in extreme, dilutional hyponatraemia. The patient was treated with two 100 mL boluses of hypertonic 3% saline but deteriorated further and required intubation. She had a complicated ICU course but went on to make a full neurological recovery. This is one of the lowest sodium levels attributed to primary polydipsia or second-generation antipsychotics reported in the literature.

Learning points

The combination of primary polydipsia and SIAD can lead to a life-threatening, extreme hyponatraemia.

SIAD is an uncommon side effect of second-generation anti-psychotics.

Serum sodium should be monitored in patients with primary polydipsia when commencing or adjusting psychotropic medications.

Symptomatic hyponatraemia is a medical emergency that requires treatment with boluses of hypertonic 3% saline.

A serum sodium of less than 105 mmol/L is associated with an increased risk of osmotic demyelination syndrome, therefore the correction should not exceed 8 mmol/L over 24 h.
Development of active packaging films based on quaternary ammonium chitosan, polyvinyl alcohol and litchi (Litchi chinensis Sonn.) pericarp extract
Authors: Liu Juge , Yao Xiyu , Yun Dawei , Zhang Man , Qian Chunlu , Liu Jun
Published: October 2021

Litchi (Litchi chinensis Sonn.) pericarp contains abundant polyphenols that are suitable materials for developing active packaging films. In this study, 1 wt%, 3 wt% and 5 wt% of litchi pericarp extract (LPE) was added into quaternary ammonium chitosan (QAC) and polyvinyl alcohol (PVA) matrix to develop active packaging films. The structural, physical and functional properties of QAC-PVA (QP) films were compared with LPE (QP-LPE films) and without LPE (QP films). Results showed QP film had a heterogenous cross-section whereas QP-LPE films displayed rough and uneven cross-sections. After adding LPE, the N–H, O–H, C – H and C=O stretching bands of QP films shifted due to the formation of intermolecular interactions between LPE and film matrix. LPE made the colorless QP film turned brown. QP-LPE films presented lower ultraviolet–visible light transmittance than QP film. After adding LPE, film thickness increased from 0.091 to 0.103 mm, film water vapor permeability increased from 14.98 × 10−11 to 17.21 × 10−11 g m−1 s−1 Pa−1, film oxygen permeability increased from 0.16 to 0.22 cm3 mm m−2 day−1 atm−1, film tensile strength increased from 14.10 to 17.41 MPa, and film elongation at break decreased from 36.94% to 25.13%. QP-LPE films quickly released polyphenols in distilled water within 4 h and displayed potent antioxidant activity. The antimicrobial ratio of the film against Escherichia coli, Salmonella typhimurium, Staphylococcus aureus and Listeria monocytogenes was elevated from 50.40−68.04% to 58.93−91.38% after adding LPE. Results suggested QP-LPE films could be utilized as antioxidant and antimicrobial packaging materials in food industry.
Cuestionario de evaluación de estrategias de aprendizaje para estudiantes universitarios (CEVEAPEU) validación con estudiantes guatemaltecos1
Authors: Aldana-Rabanales Karla Irene
Published: October 2021

El objetivo de este estudio fue determinar los parámetros de validez y confiabilidad del cuestionario de evaluación de estrategias de aprendizaje de los estudiantes universitarios (CEVEAPEU) al aplicarlo a una muestra de estudiantes guatemaltecos. El diseño es no experimental, transversal con enfoque cuantitativo y alcance descriptivo. Se aplicó en una primera etapa como pilotaje a una muestra de 72 estudiantes del primer año para verificar la validez aparente. Posteriormente, a una muestra de 341 estudiantes de segundo y tercer año, ambas fueron muestras no probabilísticas. Se procedió a establecer el nivel de confiabilidad por medio del alfa de Cronbach, se obtuvo para el total del instrumento un α = 0.914. Con el programa Factor Analysis, se realizó el análisis factorial exploratorio de cada una de las seis subescalas para determinar la validez de constructo. Se aplicó una matriz de dispersión de correlaciones policóricas, con rotación Varimax. Se omitieron los ítems con cargas factoriales inferiores a 0.300 absolutas, o que no se agruparon en un factor que tuviera tres ítems como mínimo. El programa también brindó el alfa ordinal para cada uno de los factores por subescalas y se obtuvo una aproximación al análisis factorial confirmatorio con indicadores adecuados. Como resultado, de las seis subescalas, dos mostraron factores según el modelo teórico original, y cuatro de las seis difirieron, reduciéndose el número de factores y/o de ítems para la muestra de estudiantes guatemaltecos. El instrumento final, en esta aplicación, según cargas factoriales, quedó conformado por seis subescalas, 19 estrategias y 83 ítems.
Role of catestatin in development and decompensation of heart failure: a literature review
Authors: Meshcheryakov Yu. V. , Gubareva I. V. , Gubareva E. Yu. , Alekseeva A. Yu.
Published: October 2021

The current literature review covers the role of sympathetic nervous system activation (SNS) and the significance of a new biomarker catestatin (CST), which is a chromogranin A-derived peptide, for assessing prognosis of patients with heart failure (HF). This review details the works devoted to CST metabolism and its role in clinical conditions with excessive catecholamine production, including the ability to counterbalance the adverse effects of SNS on cardiovascular system. The paper also presents the central results of studies on HF patients and shows the correlation of the CST level with HF functional class and stage. In addition, particular attention is paid on the possibilities and potential benefits of assessing the CST in addition to conventional management of patients hospitalized due to acute decompensated heart failure.
Biomarkers ST2 and interleukin 33 for assessing the severity of cardiac inflammation and fibrosis in patients with chronic heart failure
Authors: Drapkina O. M. , Kontsevaya A. V. , Kravchenko A. Ya. , Budnevskiy A. V. , Tokmachev R. E. , Chernik T. A.
Published: October 2021

Chronic heart failure (CHF) is a pathology that affects more than 37 million people worldwide. Despite the introduction of new drugs into practice, that have proven their effectiveness in the treatment of patients with CHF, the life expectancy of these patients is growing at a slow pace. At the same time, the insufficient effect of neurohormonal blockers for the treatment of patients with CHF with preserved ejection fraction (CHFpEF), which prevails in the general structure of CHF, indicates a significant role of unidentified pathological processes in the development of this form of the disease. In recent years, the role of cardiac fibrosis has been actively studied within the framework of the investigation of the pathogenesis of CHFpEF, the probable biomarkers of which are interleukin (IL) 33 and suppression of tumorigenicity 2 (ST2). This literature review examines the influence of the IL-33/ ST2 interaction as a biomarker of cardiac fibrosis on the course of CHF and the possibilities of its practical application.
Hypertrophic obstructive cardiomyopathy in a heart transplant recipient: a case report
Authors: Golovina G. A. , Stavenchuk T. V. , Kizhvatova N. V. , Kosmacheva E. D.
Published: October 2021

The article presents a case report of developing the classic hypertrophic obstructive cardiomyopathy in a 66-year-old male heart transplant recipient within 5 years after orthotopic heart transplantation. The characteristics of this pathology are discussed.
Preoperative hyperlactatemia and early mortality after liver transplantation: selection of important variables using random forest survival analysis
Authors: Cheong Yuseon , Lee Sangho , Lee Do-Kyeong , Kim Kyoung-Sun , Sang Bo-Hyun , Hwang Gyu-Sam
Published: October 2021

Background: Generally, lactate levels > 2 mmol/L represent hyperlactatemia, whereas lactic acidosis is often defined as lactate > 4 mmol/L. Although hyperlactatemia is common finding in liver transplant (LT) candidates, association between lactate and organ failures with Acute-on-chronic Liver Failure (ACLF) is poorly studied. We searched the important variables for pre-LT hyperlactatemia and examined the impact of preoperative hyperlactatemia on early mortality after LT. Methods: A total of 2,002 patients from LT registry between January 2008 and February 2019 were analyzed. Six organ failures (liver, kidney, brain, coagulation, circulation, and lung) were defined by criteria of EASL-CLIF ACLF Consortium. Variable importance of preoperative hyperlactatemia was examined by machine learning using random survival forest (RSF). Kaplan-Meier Survival curve analysis was performed to assess 90-day mortality.Results: Median lactate level was 1.9 mmol/L (interquartile range: 1.4, 2.4 mmol/L) and 107 (5.3%) patients showed > 4.0 mmol/L. RSF analysis revealed that the four most important variables for hyperlactatemia were MELD score, circulatory failure, hemoglobin, and respiratory failure. The 30-day and 90-day mortality rates were 2.7% and 5.1%, whereas patients with lactate > 4.0 mmol/L showed increased rate of 15.0% and 19.6%, respectively. Conclusion: About 50% and 5% of LT candidates showed pre-LT hyperlactatemia of > 2.0 mmol/L and > 4.0 mmol/L, respectively. Pre-LT lactate > 4.0 mmol/L was associated with increased early post-LT mortality. Our results suggest that future study of correcting modifiable risk factors may play a role in preventing hyperlactatemia and lowering early mortality after LT.
An Experiment on Growth Performance, Specific Growth Rate (SGR) and Feed Conversion Ratio (FCR) of Rohu (Labeo rohita) and Tilapia (Oreochromis niloticus) in Tank Based Intensive Aquaculture System
Authors: Md. Hashibur Rahman , Md. Arifuzzaman
Published: October 2021

The growth and survival are considered as the crucial factors that should be taken into consideration in any aquaculture system. The experiment was aimed to evaluate the growth performance and subsequent survival rate of the rohu (Labeo rohita) and tilapia (Oreochromis niloticus). It is important to evaluate the growth responses in relation to Feed Conversion Ratio (FCR) and assessment of the total production of the culture unit. As per the recommended stocking density of 320 fishes/decimal in intensive aquaculture system 8 fry per tank was released to assess the growth performance, survival and production of both rohu (T1) and tilapia (T2). During experimental period, there were three replications for each treatment and feed was supplied at the rate of 12%, 8%, and 4% of the body weight of rohu and 20%, 15%, and 10% of the body weight of tilapia in 1st, 2nd and 3rd month for T1 and T2, respectively. The initial weight of individual tilapia was 7.52±1.81 gm and 14.75±0.19 gm for T1 and T2, respectively. The mean final weight was 44.01±4.03 g for T1 and 139.94±1.29 for T2. The weight gains of fish were 36.49±4.09 gm and 125.19±1.29 gm for T1 and T2, respectively. The mean percent weight gain of tilapia was higher in T2 (1715.05±0.00) than T1 (485.23±0.00). The Specific Growth Rates (SGR) of T1 and T2 were found 4.98±2.28 and 6.26 ±3.83, respectively. There was significant difference (p>0.05) in term of SGR between the treatments. Feed Conversion Ratio (FCR) in T1 and T2 were 2.86±0.14 and 2.23±0.18, respectively. Higher total production was obtained in T2 (1119.52 gm) than T1 (278.19 gm) with 100% survival in both the treatments. The water quality parameters for both of the species were within the suitable range. This study reveals a promising arena for fish culture in tank-based intensive aquaculture system as an efficient way of overcoming the scarcity of water and land. This culture system may be an excellent way of producing fish in a small parcel of land with securing the propitious production and expected outcomes within a limited period of time.
Effetti della malattia tiroidea sul sistema cardiovascolare
Authors: Raddino Riccardo , Cersosimo Angelica , Bianchi Alfio Ernesto , Maggi Antonio
Published: October 2021

Gli ormoni tiroidei hanno un impatto significativo sulla funzione e sulla struttura cardiaca. Gli effetti cardiaci intracellulari dell’ormone tiroideo T3 si esplicano attraverso due meccanismi: genomico e non genomico, mentre la definizione di ipertiroidismo o di ipotiroidismo si basa sui livelli sierici di TSH e di concentrazioni libere degli ormoni T3 e T4 (FT3, FT4).L’ipertiroidismo è caratterizzato da un aumento della frequenza cardiaca a riposo, del volume sanguigno, della gittata sistolica, della contrattilità miocardica, della frazione di eiezione e da un miglioramento del rilassamento diastolico. L’ipotiroidismo è associato a una ridotta gittata cardiaca a causa del ridotto rilassamento della muscolatura liscia vascolare e della ridotta disponibilità di ossido nitrico endoteliale con conseguente rigidità arteriosa, aumento della resistenza vascolare sistemica e minor ritorno venoso. In considerazione degli effetti dell’ormone T3 sui cardiomiociti e sulla fisiologia cardiovascolare e metabolica, sarebbe indicata una precoce ricerca sierica dei valori di TSH, FT3 e FT4 in tutti quei pazienti con disfunzione diastolica, fibrillazione atriale, PAH, blocchi atrioventricolari, così da garantire un trattamento precoce che può invertire l’evoluzione clinica e prevenire, così, il rischio di morte cardiovascolare.
Using Internet of Things application for Monitoring Photo-Voltaic Panel Based on Ask Sensors Cloud
Authors: Mansour  S.  Farhan Mohammed Hassan Majhool, Haider Th. Salim Alrikabi,
Published: October 2021

Internet of Things (IOT) devices and monitoring systems are essential for the accurate, reliable, and proper functioning of photovoltaic (PV) solar energy systems. The data acquisition and monitoring system ensure adequate operation and ascertain system malfunctions before they become significant problems. The IOT integrates ordinary items using modern technology in the physical scope. It is all feasible to utility voltage, current, temperature, and humidity sensors. The current research focuses on developing a cost-effective, accessible, and steadfast data monitoring system. A microcontroller-based data logger is stored in a cloud. The data can be downloaded directly from the website using the IoT technique because photovoltaic (PV) panels are built-in faraway locations and humans cannot reach them. The suggested system demonstrates the online utilization of solar PV power.
Digital technologies in prostate cancer prevention and early diagnosis
Authors: Lazarev A. F. , Petrova Valentina D. , Pokornyak V. P. , Lazarev S. A. , Marchkov V. A. , Ganov D. I.
Published: October 2021

Background. Prostate cancer is one of the most common malignant neoplasms in males. The Russian Federation observed the same patterns: the incidence of prostate cancer is steadily growing, without the tendency to decrease. Currently, no effective methods are available for prostate cancer early diagnosis and screening.
Aim. To improve the effectiveness of prostate cancer prevention and early diagnosis with new digital technologies for high-risk cancer group formation
Material and methods. Data from the Cancer Registry population in the Altai regional cancer center, Barnaul City was used. The Cancer Registry includes information about 253,000 patients with malignant neoplasms, including 14,482 males suffering from prostate cancer. Based on the targeted prevention method of A.F. Lazarev, Method for determining the risk of prostate cancer (Patent 2692987) and Automated program for early diagnosis of prostate cancer (certificate of state registration of the computer program No. 2019663514) was developed, which simplifies the stage of forming groups of precancerous high oncorisk and increases prostate cancer detection, as well as develops personalized targeted preventive measures for each patient.
Results. The study formed a group of 328 patients with precancerous high oncorisk for prostate cancer in the Cancer Registry, wherein an in-depth examination revealed 26 patients with prostate cancer, which was 7.9%. Stages I and II were established in 97.8%.
Conclusion. The web application Automated program for early diagnosis of prostate cancer allows the group formation of high-risk patients who are a targeted search for prostate cancer. The testing process allows a large number of patients to be examined in a short time. The automated program for the early diagnosis of prostate cancer allows a statistically significant increased prostate cancer detection, as well as personalized preventive measure suggestions for each patient.
Paulo Leminski e a expressão poética da “várzea”
Authors: Kühn Ana Érica Reis da Silva
Published: October 2021

Este artigo analisa como Paulo Leminski forjou uma expressão poética da “várzea” para a sua poesia, visando tornar a sua obra criativa acessível ao público mediano. A “várzea” é uma palavra utilizada pelo poeta, e consta nas suas cartas e poemas. Trata-se de uma referência ao que está à margem da cultura erudita. Consideramos que os recursos que favorecem a comunicação com o leitor horizontal, a exemplo dos jogos paronomásticos e sonoros, a brevidade e a coloquialidade, tão presentes na dicção leminskiana, fazem parte do que o poeta concebeu como “várzea” poética. Para tecermos nossa análise, nos debruçamos sobre poemas, ensaios críticos, e, também, sobre as epístolas enviadas ao amigo Bonvicino. As cartas guardam um diálogo teórico-crítico que lança luz sobre o entendimento e o encaminhamento que Leminski concedeu a sua poesia.
prosa através
Authors: Dos Passos Lucas
Published: October 2021

No início dos anos 1980, surgiu em Curitiba uma revista que teria vida curta e que veicularia, em três de suas primeiras edições, novela inédita e incompleta de Paulo Leminski. “Minha classe gosta/Logo, é uma bosta.” não figura em nenhum dos livros de Leminski; ficou, assim, circunscrita àqueles três números da Raposa magazine – revista de cultura que, desde a capa, prometia vincular “humor e rumor”. O clima contracultural da Curitiba – e do Brasil – dos anos 1980 se vê refletido não só na idealização da revista, como também de maneira especial na novela leminskiana, que opera uma releitura da década anterior sem obliterar as questões políticas que estavam no centro das discussões. Com vistas a alinhar as questões éticas levantadas pela narrativa em pauta ao apuro estético de um poeta muito atento às revoluções formais do século XX, esta análise se acerca do texto de Leminski municiada das considerações de Theodor Adorno (1982; 2003) sobre a importância da forma como conteúdo sedimentado – que medeia e incorpora a barbárie do mundo –, com apoio nas leituras feitas por Jaime Ginzburg (2012) e Verlaine Freitas (2008); além disso, ensaios de Roberto Schwarz (1978), Carlos Alberto Messeder Pereira (1993), Elio Gaspari (2000; 2014) e Bernardo Kucinski (2001) ajudarão a compor o cenário histórico brasileiro dos anos 1960 aos 1980.
De como anseios se tornam ensaios
Authors: Moreira Paula Renata
Published: October 2021

O presente artigo tem por objetivo analisar uma pequena parte da produção ensaística de Paulo Leminski, personagem polímata, que agiu em várias frentes, tendo escrito poemas, romances, contos, entre outros gêneros, bem como operou em ramos variados da cultura, como a produção visual. Em relação à obra ensaística, escreveu para grande imprensa, atuou em publicações alternativas e lançou livros. Neste artigo, serão postos em evidência alguns textos tanto republicados quanto feitos especialmente para o lançamento de seu primeiro livro de ensaios, Anseios crípticos: anseios teóricos: peripécias de um investigador do sentido no torvelinho das formas e ideias, de 1986, pela Criar Edições, de Curitiba. Os ensaios analisados relacionam-se a temas recorrentes na poética deste autor. Intenciona-se, assim, perceber como as manifestações “teórico-críticas” de Leminski entram em consonância com sua atividade poética.
Galáxia dark no fio da navalha de Walter Benjamin
Authors: Bomfim Monalisa Medrado
Published: October 2021

Galáxias (1984) é um livro de Haroldo de Campos que transita entre linguagens e suportes. Entre as experimentações de Galáxias (1984), destaco a transcriação cinematográfica, operada por Julio Bressane e Haroldo de Campos. A dupla produziu dois vídeos-poemas: Galáxia albina (1992) e Infernalário: logodédalo – Galáxia dark (1993). O objetivo desse trabalho foi pensar a transcriação do poema Galáxias (1984) para o vídeo-poema Infernalário: logodédalo – Galáxia dark (1993) por meio da navalha benjaminiana que compõe a teoria poética de Haroldo de Campos. Teceu-se a análise a partir dos fragmentos 4 e 48 de Galáxias (1984) e do ensaio “Sobre o conceito da história” (1940) de Walter Benjamin, elencando aspectos estéticos e críticos que permitiram problematizar e trazer o vídeo-poema para as discussões do presente.
Clics de Curitiba pelo polaco louco
Authors: Fernandes Ana
Published: October 2021

O poeta curitibano Paulo Leminski, em colaboração com o fotógrafo Jack Pires, publicam, em 1976, Quarenta Clics em Curitiba. O volume reúne quarenta páginas soltas, sem numeração, que os autores chamam de “pranchas”. Quarenta fotografias, de Pires, e quarenta poemas, de Leminski, são integrados no mesmo espaço de leitura que compõe o livro-objeto ou livro-caixa. A arquitetura do livro, sua estrutura solta e sem numeração, impede qualquer sequencialização orientada de leitura, e cria o que pode ser interpretado como a memória de um deslocamento des-hierarquizado por ruas sem endereço, numa cidade paratática. Impedido de criar focos de atenção, sequências ou estruturas narrativas, o fotolivro “recria” o ato de passear pela cidade, ou o que pode ser interpretado como um deslocamento por instantes ou ocorrências independentes da cidade. Quarenta Clics é o mais notável experimento do envolvimento do poeta com sua cidade, a presença do registro imediato do cotidiano curitibano. Exploro, neste artigo, o experimento intermidiático que é Quarenta Clics em Curitiba, com atenção a densa relação poeta-cidade.
Investigation of the Biocontrol Effectiveness of Some Bacterial Strains on Eggplant Gray Mold Disease (Botrytis cinerea) in in vitro and in vivo conditions
Authors: AKÇA Alican , TOZLU Elif
Published: October 2021

Gray mold agent Botrytis cinerea (teleomorph: Botryotinia fuckliana (de Barry) Whetzel) causes significant yield losses in many economically important vegetables. Chemicals are used in the control to reduce yield loss. As a result of the intensive use of chemicals in the control of plant diseases, human health and the environment are adversely affected. Therefore, interest in environmentally friendly control practices has increased recently. One such application is the use of benefical bacteria in the biological control of diseases. In this study; biocontrol potentials of 12 bioagent bacteria strains (1 Bacillus cereus, 2 Bacillus megaterium, 2 Bacillus pumilus, 2 Bacillus subtilis, 1 Bacillus thuringiensis subsp. kurstaki, 1 Paenibacillus polymyxa, 2 Pantoea agglomerans and 1 Pseudomonas fluorescens) have been determined against gray mold disease agent B. cinerea on eggplant in vitro and in vivo. Pseudomonas chlororaphis supsp. aurofaciens and Bacillus amyloliquefaciens, which were the most efficient strains found in vitro conditions, were also effective against B. cinerea in vivo. In conclusion, it was determined that two most effective bacterial strains could be used as a biocontrol agent in the biological control of B. cinerea in eggplant growing.
Türkiye Akdeniz Kıyılarında Derin Su Pembe Karidesinde (Parapenaeus longirostris, H. Lucas 1846) Oksidatif Stres Parametreleri, Metal Birikimi ve Sağlık Risk Değerlendirmesi
Authors: DOĞAN Serdar , DUYSAK Önder , DUYSAK Taner , UĞURLU Erkan
Published: October 2021

Bu çalışmada; Akdeniz’in İskenderun ve Antalya lokal balıkçılarından Eylül 2020’de temin edilen derin su pembe karideslerinde (Parapenaeus longirostris, H. Lucas 1846) kas dokusunda birikim gösteren demir (Fe), bakır (Cu), çinko (Zn), manganez (Mn), nikel (Ni), kobalt (Co), Alüminyum (Al), krom (Cr), kadmiyum (Cd) ve kurşun (Pb) metal düzeyleri, ve yine aynı dokulardaki Malondialdehit (MDA) seviyesi ve Katalaz (KAT) enzim aktivitesi belirlenmiştir. Bu iki bölgede tüketilen karideslerde insan sağlığı riskleri, haftalık tüketim miktarları ve kanser risk değerlendirmeleri hesaplanmıştır. Hesaplanan en yüksek metal konsantrasyonu Antalya’da Fe (35.976±2.992 mg kg-1), en düşük birikim ise aynı istasyonda Cd (0.002±0.001 mg kg-1) için hesaplanmıştır. Oksidatif stres parametrelerinden MDA miktarı İskenderun’da avlanan karideslerde 11.06±0.36 nmol mg-1 protein, Antalya’da avlanan karideslerde 8.63±0.13 nmol mg-1 protein, KAT enzim aktivitesinin ise Antalya’da 3.7±0.15 k g-1 protein ve İskenderun’da 6.6±0.4 k g-1 protein olarak hesaplanmıştır. Bu sonuçlara göre ağır metal birikiminin karides türünde lipid peroksidasyonuna neden olduğu anlaşılmıştır. İnsan sağlığı riskleri, tahmini haftalık tüketim (EWI) değerlerinin, Avrupa Gıda Güvenliği (EFSA) ve Gıda Tarım/Dünya Sağlık Örgütü (FAO/WHO) tarafından belirlenen tolere edilebilir haftalık alım (PTWI) değerlerinin altında olduğu belirlenmiştir. Tüketici açısından kanser dışı sağlık risklerinin göstergesi olan hedef tehlike katsayısı (THQ) ve tehlike indeksi (HI) değerleri
Vamos todos aprender a ler: formador de palavras
Authors: Dueñas Ximena , Duarte Salcedo Catalina , de Almeida Sargiani Renan , Navas Ana Luiza
Published: October 2021

"Vamos todos aprender a ler" é uma iniciativa de alfabetização inicial do BID, por meio da qual são oferecidos materais para alunos e professores e recursos para a sala de aula. O programa tem como objetivo fornecer ferramentas de apoio e seqüência de atividades de ensino explícito das habilidades fundamentais para a alfabetização com base na história de personagens animais cujo nome se inicia por um fonema alvo. Este formador de palavras é um recurso que serve para fortalecer a conexão entre os fonemas (sons) e os grafemas (letras) podendo ser utilizado para expandir as atividades de leitura e de escrita. Trata-se de um material complementar que, como metodologia ativa, busca ampliar o desenvolvimento e consolidar aprendizagens.
Vamos todos aprender a ler: Caderno 3 do aluno: primeiro ano
Authors: Dueñas Ximena , Duarte Salcedo Catalina , de Almeida Sargiani Renan , Navas Ana Luiza
Published: October 2021

"Vamos todos aprender a ler" é a iniciativa de alfabetização inicial do BID, a qual por meio de materiais para o aluno, o professor e a sala de aula, visa fornecer ferramentas de apoio ao processo de alfabetização inicial. O programa é organizado a partir de uma cartela fonológica apresentando para cada fonema (letra sonora) um personagem caracterizado por um animal. Esta cartilha para o aluno do primeiro ano do ensino fundamental permite que ele faça os exercícios do terceiro bimestre. Está prevista a entrega de uma cópia para cada aluno.
Vamos todos aprender a ler: Caderno 2 do aluno: pré-escola
Authors: Dueñas Ximena , Duarte Salcedo Catalina , de Almeida Sargiani Renan , Navas Ana Luiza
Published: October 2021

"Vamos todos aprender a ler" é uma iniciativa de alfabetização inicial do BID, por meio da qual são oferecidos materais para alunos e professores e recursos para a sala de aula. O programa tem como objetivo fornecer ferramentas de apoio e seqüência de atividades de ensino explícito das habilidades fundamentais para a alfabetização com base na história de personagens animais cujo nome se inicia por um fonema alvo. Esta cartilha para o aluno da pré-escola permite que a criança faça os exercícios do segundo semestre. Está prevista a entrega de uma cópia para cada aluno.
Vamos todos aprender a ler: Guia do professor: primeiro ano
Authors: Dueñas Ximena , Duarte Salcedo Catalina , de Almeida Sargiani Renan , Navas Ana Luiza
Published: October 2021

"Vamos todos aprender a ler" é uma iniciativa de alfabetizaçao inicial do BID, por meio da qual sao oferecidos materais para alunos e professores e recursos para a sala de aula. O programa tem como objetivo fornecer ferramentas de apoio e sequencia de atividades de ensino explícito das habilidades fundamentais para a alfabetizaçao com base na história de personagens animais cujo nome se inicia por um fonema alvo. Este guia do professor do primeiro ano do ensino fundamental o orienta nas atividades a serem realizadas com os alunos durante o ano escolar. Está prevista a entrega de uma cópia para cada professor.
Experimental measurements on the effect of vehicle movement direction on received signal power in V2V communication
Authors: KUZULUGİL Kenan , HASIRCI Zeynep , ÇAVDAR İsmail
Published: October 2021

Vehicle-to-Vehicle (V2V) communication has been a popular topic in recent years. V2V communication channel measurements in different environments and scenarios have been performed to reveal the effect of different parameters such as vehicles, buildings, or trees. However, vehicle movement direction is generally neglected when the measurement data are analyzed. In this study, V2V channel measurements were carried out in open roads similar to a highway but with less traffic. The measurement data are divided into two groups: the vehicles approaching each other and moving away from each other. The effect of vehicle movement direction on the received signal power is indicated by comparing the received signal power values of these two groups. The results show that the received signal power differs depending on vehicle movement direction. However, according to our findings, it is not clear which movement direction causes more path loss. The authors suggest that vehicle movement direction should be taken into account in analyzing, modeling, and simulations of V2V communication channel.
The investigation of fuel properties of mixtures obtained by adding waste sunflower biodiesel and ethanol to euro diesel fuel
Authors: AYDIN Fatih
Published: October 2021

Energy production from waste in the world will be an indispensable factor for the future of countries. Countries that can produce their own energy in the world will be superior to other countries. In this study, waste sunflower oil was converted to methyl ester by transesterification method and biodiesel was produced. A Ternary mixture was made from biodiesel, ethanol and euro diesel fuel obtained from waste sunflower oil and test fuels were produced in the forms of D90B5E5, D80B10E10, D70B15E15 and D60B20E20. The kinematic viscosities of the test fuels at 40 0C, density, water contents, pH values, color specifications, calorific values, cloud points, yield points, freezing, copper strip corrosion tests, CFPP tests and cetane index tests were carried out and fuel properties were determined. As a result of the tests, it was found out that the most suitable engine fuel mixture was D90B5E5. It can be used for internal combustion engines by adding ethanol to the Biodiesel – Euro diesel fuel mixture and in this way, an environmentally friendly fuel mixture is obtained and energy conversion is achieved from waste.
Word-embedding Based Text Vectorization Using Clustering
Authors: Yuferev Vitaly I. , Razin Nikolai A.
Published: October 2021

It is known that in the tasks of natural language processing, the representation of texts by vectors of fixed length using word-embedding models makes sense in cases where the vectorized texts are short.

The longer the texts being compared, the worse the approach works. This situation is due to the fact that when using word-embedding models, information is lost when converting the vector representations of the words that make up the text into a vector representation of the entire text, which usually has the same dimension as the vector of a single word.

This paper proposes an alternative way for using pre-trained word-embedding models for text vectorization. The essence of the proposed method consists in combining semantically similar elements of the dictionary of the existing text corpus by clustering their (dictionary elements) embeddings, as a result of which a new dictionary is formed with a size smaller than the original one, each element of which corresponds to one cluster. The original corpus of texts is reformulated in terms of this new dictionary, after which vectorization is performed on the reformulated texts using one of the dictionary approaches (TF-IDF was used in the work). The resulting vector representation of the text can be additionally enriched using the vectors of words of the original dictionary obtained by decreasing the dimension of their embeddings for each cluster.

A series of experiments to determine the optimal parameters of the method is described in the paper, the proposed approach is compared with other methods of text vectorization for the text ranking problem – averaging word embeddings with TF-IDF weighting and without weighting, as well as vectorization based on TF-IDF coefficients.
ESTIMATION OF RELIABILITY OF CLINICAL STUDY RESULT OF BOVHYALURONIDASE AZOXYMER MEDICATION APPLIED TO CATS WITH UROLOGICAL DISEASES
Authors:   Federal State Budgetary Educational Institution of Higher Education Saint Petersburg State University of Veterinary Medicine, Nazarova A.V. , Semenov B.S. ,   Federal State Budgetary Educational Institution of Higher Education Saint Petersburg State University of Veterinary Medicine, Kuznetsova T. Sh. ,   Federal State Budgetary Educational Institution of Higher Education Saint Petersburg State University of Veterinary Medicine
Published: October 2021

The article interprets the results of a randomized, blind, placebo-controlled, confirmatory clinical study of the efficacy of bovhyaluronidase azoxymer (BA) applied to cats with urological diseases, conducted in parallel groups on the basis of “Bars” veterinary clinics in Petersburg and the Department of Obstetrics and Operative Surgery of St. Petersburg State University of Veterinary Medicine from November 2018 to August 2020. To prove the causal relationship between the application of BA and a significant decrease of the number of complications in the postoperative period, we used a three-stage system for analyzing the results. The reliability of our study is confirmed by the following: 1) a sufficient sample number corresponding to that calculated at the planning stage of the clinical study (53 cats: 24 were included in the experimental group and 29 were in the control group) that had indications for surgery on the urethra and / or bladder; 2) a sufficient value of the confirmed effect: when BA was used, the risk of complications was 80.9% lower, and the chance of complications decreased by 12.2 times; 3) correct randomization and blinding, which made it possible to obtain representative samples: block randomization and blinding by territory were carried out; 4) standardization of animal registration and data collection: all animals were examined in accordance with the requirements of GOST R 58090-2018 “Clinical examination of nonproductive animals”; 5) the presence of placebo control. The revealed decrease of the frequency of complications with BA is explained by the action mechanism of the studied medication in the body. The results of clinical studies indicate that application of BA medication in the therapy of companion animals is clinically justified and can be extended beyond the observed population. The obtained results allow us to assert that application of BA significantly reduces the complications associated with the performed surgical intervention or the recurrence of the disease within six months after the first operation.