bluuebunny/crossref_metadata_2025 huggingface dataset:
Formulated Phospholipids as Non-Canonical TLR4 Agonists
Authors: Liang Hong , Lykins William R. , Seydoux Emilie , Guderian Jeffrey A. , Phan Tony , Fox Christopher B. , Orr Mark T.
Published: November 2022

Immunogenic agents known as adjuvants play a critical role in many vaccine formulations. Adjuvants often signal through Toll-like receptor (TLR) pathways, including formulations in licensed vaccines that target TLR4. While TLR4 is predominantly known for responding to lipopolysaccharide (LPS), a component of Gram-negative bacterial membranes, it has been shown to be a receptor for a number of molecular structures, including phospholipids. Therefore, phospholipid-based pharmaceutical formulations might have off-target effects by signaling through TLR4, confounding interpretation of pharmaceutical bioactivity. In this study we examined the individual components of a clinical stage oil-in-water vaccine adjuvant emulsion (referred to as a stable emulsion or SE) and their ability to signal through murine and human TLR4s. We found that the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) activated TLR4 and elicited many of the same immune phenotypes as canonical TLR4 agonists. This pathway was dependent on the saturation, size, and headgroup of the phospholipid. Interestingly, DMPC effects on human cells were evident but overall appeared less impactful than emulsion oil composition. Considering the prevalence of DMPC and other phospholipids used across the pharmaceutical space, these findings may contextualize off-target innate immune responses that could impact preclinical and clinical development.
Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?
Authors: Kovacs Tamas , Nagy Peter , Panyi Gyorgy , Szente Lajos , Varga Zoltan , Zakany Florina
Published: November 2022

Cyclodextrins, representing a versatile family of cyclic oligosaccharides, have extensive pharmaceutical applications due to their unique truncated cone-shaped structure with a hydrophilic outer surface and a hydrophobic cavity, which enables them to form non-covalent host–guest inclusion complexes in pharmaceutical formulations to enhance the solubility, stability and bioavailability of numerous drug molecules. As a result, cyclodextrins are mostly considered as inert carriers during their medical application, while their ability to interact not only with small molecules but also with lipids and proteins is largely neglected. By forming inclusion complexes with cholesterol, cyclodextrins deplete cholesterol from cellular membranes and thereby influence protein function indirectly through alterations in biophysical properties and lateral heterogeneity of bilayers. In this review, we summarize the general chemical principles of direct cyclodextrin–protein interactions and highlight, through relevant examples, how these interactions can modify protein functions in vivo, which, despite their huge potential, have been completely unexploited in therapy so far. Finally, we give a brief overview of disorders such as Niemann–Pick type C disease, atherosclerosis, Alzheimer’s and Parkinson’s disease, in which cyclodextrins already have or could have the potential to be active therapeutic agents due to their cholesterol-complexing or direct protein-targeting properties.
Examining Routine Pediatric Vaccination Availability in Community Pharmacies in Washington State
Authors: McKeirnan Kimberly Caye , Motzner Madison Shea , Kherghehpoush Sorosh
Published: November 2022

To address diminishing pediatric vaccination rates resulting from the COVID-19 pandemic, the Public Readiness and Emergency Preparedness (PREP) Act allows pharmacists, technicians, and pharmacy interns to administer any vaccine that the Advisory Committee on Immunization Practices (ACIP) guidelines recommend for all patients aged 3 years and older. A survey was conducted to evaluate the role of pharmacy personnel in the community setting providing immunizations for the pediatric patients. Sixty-seven pharmacies were contacted in a state where pharmacists are allowed to administer vaccinations to any patient over the age of six months. Of the 58 respondent pharmacies offering vaccinations for pediatric patients, the most commonly reported vaccines included influenza (97%), tetanus, diphtheria, and pertussis (88%), hepatitis (71%), human papillomavirus (69%), meningococcal vaccines (66%), polio (45%), and Haemophilus influenzae type b vaccine (40%). Nearly all respondent pharmacies (56/58) reported having at least one of the ACIP-recommended routine childhood vaccinations available for patients under the age of 18. Community pharmacies are well-positioned to administer routine vaccinations to pediatric patients and address declining pediatric vaccination rates.
The Biostimulant Effect of Hydroalcoholic Extracts of Sargassum spp. in Tomato Seedlings under Salt Stress
Authors: Sariñana-Aldaco Oscar , Benavides-Mendoza Adalberto , Robledo-Olivo Armando , González-Morales Susana
Published: November 2022

Currently, the use of biostimulants in agriculture is a tool for mitigating certain environmental stresses. Brown algae extracts have become one of the most important categories of biostimulants in agriculture, and are derived from the different uses and positive results obtained under optimal and stressful conditions. This study aimed to examine the efficacy of a foliar application of a hydroalcoholic extract of Sargassum spp. and two controls (a commercial product based on Ascophyllum nodosum and distilled water) with regard to growth, the antioxidant system, and the expression of defense genes in tomato seedlings grown in nonsaline (0 mM NaCl) and saline (100 mM NaCl) conditions. In general, the results show that the Sargassum extract increased the growth of the seedlings at the end of the experiment (7.80%) compared to the control; however, under saline conditions, it did not modify the growth. The Sargassum extract increased the diameter of the stem at the end of the experiment in unstressed conditions by 14.85% compared to its control and in stressful conditions by 16.04% compared to its control. Regarding the accumulation of total fresh biomass under unstressed conditions, the Sargassum extract increased it by 19.25% compared to its control, and the accumulation of total dry biomass increased it by 18.11% compared to its control. Under saline conditions, the total of fresh and dry biomass did not change. Enzymatic and nonenzymatic antioxidants increased with NaCl stress and the application of algal products (Sargassum and A. nodosum), which was positively related to the expression of the defense genes evaluated. Our results indicate that the use of the hydroalcoholic extract of Sargassum spp. modulated different physiological, metabolic, and molecular processes in tomato seedlings, with possible synergistic effects that increased tolerance to salinity.
Endophytic Beauveria bassiana Induces Oxidative Stress and Enhances the Growth of Fusarium oxysporum-Infected Tomato Plants
Authors: Nchu Felix , Macuphe Neo , Rhoda Ilyaas , Niekerk Lee-Ann , Basson Gerhard , Keyster Marshall , Etsassala Ninon G. E. R.
Published: November 2022

Studying the mechanisms through which endophytic fungi confer protection to host plants against parasites will contribute toward elucidating the endophytic fungi–plant–pathogen relationship. In this study, we evaluated the effects of endophytic Beauveria bassiana on the antioxidant activity, oxidative stress, and growth of tomatoes infected with the fusarium wilt pathogen, Fusarium oxysporum f. sp. lycopersici (FOL). Tomato seedlings were inoculated with B. bassiana conidia and then contaminated with FOL experimentally. Four treatments (Control [T1], FOL only [T2], B. bassiana only [T3], and B. bassiana and FOL [T4]) were assessed. The plants from the B. bassiana and FOL treatment (T4) were significantly taller (DF = 3, 56; p < 0.001) and produced more leaves and aerial part biomass than those treated with only FOL (T2). Remarkably, plants in the two treatments with FOL (T2 and T4) had the lowest antioxidant activities; meanwhile, plants from the FOL treatment (T2) had the lowest ROS (superoxide and hydroxyl radicals) contents. Broadly, strong positive correlations between ROS and all the plant growth parameters were recorded in this study. While the current results revealed that the endophytic entomopathogen B. bassiana enhanced antioxidant capacity in plants, it did not improve the antioxidant capacity of F. oxysporum-infected plants. It is possible that the pathogenic FOL employed a hiding strategy to evade the host immune response and the antagonistic actions of endophytic B. bassiana. In conclusion, B. bassiana inoculum enhanced the growth of tomatoes infected with FOL, induced higher oxidative stress in both F. oxysporum-infected and -uninfected tomatoes, and improved antioxidant activities in plants inoculated with B. bassiana only.
Potassium Application Enhanced Plant Growth, Mineral Composition, Proximate and Phytochemical Content in Trachyandra divaricata Kunth (Sandkool)
Authors: Bulawa Bakholise , Sogoni Avela , Jimoh Muhali Olaide , Laubscher Charles Petrus
Published: November 2022

Wild leafy vegetables are commonly included in the diet of people in rural homesteads. Among various wild edible vegetables in South Africa, Trachyandra divaricata (Sandkool) is one of the most abundant but underutilized due to the dearth of literature on its cultivation and nutritional value. In the present study, the effect of potassium application and pruning on growth dynamics, mineral composition, and proximate and phytochemical content in T. divaricata were evaluated. Treatments consisted of three potassium concentrations (0.0072, 0.0144, and 0.0216 M) supplemented in the form of potassium sulphate (K2SO4) with four pruning levels (unpruned, 5, 10, and 15 cm) applied in each treatment. The potassium doses were added to the nutrient solution, while the control treatment was sustained and irrigated with nutrient solution only. The results revealed a significant increase in flower bud yield, height, total dry and wet weight of shoots and roots, as well as ash and neutral detergent fibre in plants irrigated with 0.0072 M of K2SO4 without pruning. Conversely, chlorophyll content and Ca were comparable among treatments, while the highest yield of Na, P, N, and Zn was recorded in treatment 100 mL of K2SO4 with 10 cm pruning. Likewise, the highest antioxidant value (Polyphenols, Flavonol and DPPH) was obtained from plants irrigated with 0.0072 M of K2SO4 with 10 cm pruning. Based on these findings, T. divaricata is a promising leafy vegetable as a minimum dose (0.0072 M) of K with moderate pruning optimised its productivity in terms of growth, biomass parameters, nutritional content, and antioxidant potential. Due to its rich nutritional value, the plant should be domesticated and studied further for its potential nutraceutical benefits.
The Impact of Salt Accumulation on the Growth of Duckweed in a Continuous System for Pig Manure Treatment
Authors: Lambert Marie , Devlamynck Reindert , Fernandes de Souza Marcella , Leenknegt Jan , Raes Katleen , Eeckhout Mia , Meers Erik
Published: November 2022

Duckweed (Lemna) is a possible solution for the treatment of aqueous waste streams and the simultaneous provision of protein-rich biomass. Nitrification-Denitrification effluent (NDNE) from pig manure treatment has been previously used as a growing medium for duckweed. This study investigated the use of a continuous duckweed cultivation system to treat NDNE as a stand-alone technology. For this purpose, a system with a continuous supply of waste streams from the pig manure treatment, continuous biomass production, and continuous discharge that meets the legal standards in Flanders (Belgium) was simulated for a 175-day growing season. In this simulation, salt accumulation was taken into account. To prevent accumulating salts from reaching a toxic concentration and consequently inhibiting growth, the cultivation system must be buffered, which can be achieved by altering the depth of the system. To determine the minimum depth of such a system, a tray experiment was set up. For that, salt accumulation data obtained from previous research were used for simulating systems with different pond depths. It was found that a depth of at least 1 m is needed to prevent a significant relative growth inhibition at the end of the growing season compared to the start. This implies a high water consumption (5–10 times more than maize). As a response, a second cultivation system was investigated for the use of more concentrated NDNE. For this purpose, salt tolerance experiments were conducted on synthetic and biological media. Surprisingly, it was observed that duckweed grows better on diluted NDNE (to 75% NDNE, or EC of 8 mS/cm) than on a synthetic medium (EC of 1.5 mS/cm), indicating the potential of such a system.
Research Progress on Dormancy Mechanism and Germination Technology of Kobresia Seeds
Authors: Wang Na , Zhang Zhonghua , Xu Wenhua , Zhou Huakun , Ning Rongchun
Published: November 2022

Kobresia is a subfamily of Cyperaceae, a perennial herbaceous plant that stores a large amount of organic carbon and nutrients (nitrogen, phosphorus, etc.) in the soil. This type of grass is soft and appreciated by all kinds of farm animals. It is one of the predominantly excellent fodder on the Qinghai–Tibet Plateau. Its good growth plays an important role in developing the local economy and maintaining ecological balance on the Qinghai–Tibet Plateau as well. The main objectives of this review are to systematically present and analyze the factors responsible for the low germination rate of Kobresia and to analyze the physical and chemical methods that are used in order to alleviate dormancy and to improve the germination rate of Kobresia seeds. This is performed in order to lay the foundation for future research in this field. At the same time, we have analyzed the research deficiencies and formulated recommendations for the future. This review will provide comprehensive information in order to reduce the cost of planting Kobresia, as well as to provide theoretical support and technical guidance for the purposes of ecosystem restoration and livestock development.
Dynamic Response of Components Containing Polymer Composites in the Resonance Region for Vibration Amplitudes up to 5g
Authors: Murčinková Zuzana , Adamčík Pavel , Sabol Dominik
Published: November 2022

This paper focuses on high-speed-operation textile machines with the aim of increasing the rotational speed by operating within the resonance region to vibration amplitudes up to 5g. The native design does not allow keeping the vibration amplitude under 5g, which is a safe operation mode, for revolutions more than 120,000 min−1. The innovative modification of the design was made by the incorporation of polymer composite materials with carbon dust, glass hollow microspheres, and silica sand fillers to the rotor-bearing casing; moreover, through the incorporation of a multilayered foam composite structure and particle damper to the pressure plate of the mechanical machine system. By using the approach of supplementing with high-damping composites, the existing native design can be used, thus avoiding the costly production of new components and subassemblies with modified shapes and dimensions. Twelve possible combinations of mentioned modifications were tested, evaluated and compared with the native design made of steel, as standard structure material in mechanical engineering. The average vibration amplitudes were evaluated in the region before the resonance peak and in the range of the resonance peak, i.e., 120,000–135,000 min−1. Significant vibration amplitude reductions in the range from 30 to 70% of the average vibration amplitude were obtained. The vibration amplitude reduction results were evaluated considering the mass through the amplitude reduction efficiency coefficient.
Norbornene as Key for a Possible Efficient Chemical Recycling in Structures Based on Ethylene
Authors: Calles-Valero Antonio F. , García-Peñas Alberto , Cerrada María L. , Gómez-Elvira José M.
Published: November 2022

Different circular strategies attempt to increase the energy efficiency or reduce the accumulation of plastic in landfills through the development of circular polymers. Chemical recycling is essential to recover the initial monomers from plastic residues for obtaining new goods showing the same properties as those using virgin monomers from the initial feedstocks. This work addresses the preparation of poly(ethylene-co-norbornene) copolymers for a promising generation of materials for energy applications that could be treated by chemical recycling. The thermal and thermo-oxidative stability for these copolymers with norbornene is higher than for the neat PE, while their degradation exhibits an activation energy lower than that observed in PE, pointing out that chemical recycling would require a lower energy consumption.
Thermochemical Transition in Non-Hydrogen-Bonded Polymers and Theory of Latent Decomposition
Authors: Tsioptsias Costas
Published: November 2022

Although thermosets and various biopolymers cannot be softened without being decomposed, the vast majority of thermoplastics are believed to exhibit thermal transitions solely related to physical alterations of their structure—a behavior typical of low molecular weight substances. In this study, Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and Thermogravimetry (TGA) were used to study the softening of four common non-hydrogen-bonded thermoplastic polymers (polypropylene, polypropylene-grafted-maleic anhydride, poly(vinyl chloride) and polystyrene) along with a hydrogen-bonded polymer as a reference, namely, poly(vinyl alcohol). It is shown that the softening of these polymers is a thermochemical transition. Based on fundamental concepts of statistical thermodynamics, it is proposed that the thermal transition behavior of all kinds of polymers is qualitatively the same: polymers cannot be softened without being decomposed (in resemblance with their incapability to boil) and the only difference between the various types of polymers is quantitative and lies in the extent of decomposition during softening. Decomposition seems to reach a local maximum during softening; however, it is predicted that polymers constantly decompose even at room temperature and, by heating, (sensible) decomposition is not initiated but simply accelerated. The term “latent decomposition” is proposed to describe this concept.
The Synergistic Toughening and Strengthening Effects of Cork Particles and Nanocellulose on Rosin-Based Epoxy Resin
Authors: Sun Jingrong , Bai Jinmeng , Li Jingjing
Published: November 2022

In order to develop a bio-based epoxy resin with high mechanical and thermal performance, cork particles and nanocellulose were introduced into the rosin-based epoxy resin to improve the toughness, stiffness and thermal stability. The flexural properties of the epoxy composites indicated that the strength and modulus were reduced when the content of cork particles was relatively high (>3%) due to the low stiffness and modulus of cork itself. However, the flexural performance was significantly improved after the addition of 1% nanocellulose. In contrast to the flexural properties, the impact toughness results showed the synergistic toughening effects of nanocellulose and cork particles on the rosin-based epoxy resin. The highest impact toughness of 13.35 KJ/m2 was found in the epoxy composite with 1% cellulose nanofibers and 3% cork particles, an increase of 149.07% compared to the neat epoxy. Cork particle size also had a significant effect on the mechanical properties of the composites. Both the flexural and impact results showed first a rise and then a fall with a decrease in the cork size. TGA results indicated cork particles and nanocellulose could have a synergistic enhancing effect on the thermal stability of the rosin-based epoxy resin. This work can add value to rosin and cork waste and widen the industrial applications of the epoxy resin.
Potent Application of Scrap from the Modified Natural Rubber Production as Oil Absorbent
Authors: Thitithammawong Anoma , Saiwari Sitisaiyidah , Salaeh Subhan , Hayeemasae Nabil
Published: November 2022

The production of raw natural rubber always ends up with leftover latex. This latex is later collected to produce low grades of rubber. The collection of this latex also depends on the latex’s quality. However, reproducing the latex may not be applicable if the latex contains many specks of dirt which will eventually be discarded. In this work, an alternative solution was to utilize such rubber in a processable form. This scrap rubber (SR) from the production of natural rubber grafted with polymethyl methacrylate (NR-g-PMMA) production was recovered to prepare an oil-swellable rubber. The rubber blends were turned into cellular structures to increase the oil swellability. To find the suitable formulation and cellular structure of the foam, the foams were prepared by blending SR with virgin natural rubber (NR) at various ratios, namely 0/100, 20/80, 30/70, 50/50, 70/30, 80/20, and 100/0 (phr/phr). The foam formation strongly depended on the SR, as it prevented gas penetration throughout the matrix. Consequently, small cells and thick cell walls were observed. This structure reduced the oil swellability from 7.09 g/g to 5.02 g/g. However, it is interesting to highlight that the thermal stability of the foam increased over the addition of SR, which is likely due to the higher thermal stability of the NR-g-PMMA waste or SR. In summary, the blending NR with 30 phr of SR provided good oil swellability, processability, and morphology, which benefit oil recovery application. The results obtained from this study will be used for further experiments on the enhancement of oil absorbency by applying other key factors. This work is considered a good initiative for preparing the oil-absorbent material based on scrap from modified natural rubber production.
Improving the Powder Properties of an Active Pharmaceutical Ingredient (Ethenzamide) with a Silica Nanoparticle Coating for Direct Compaction into Tablets
Authors: Tadauchi Tatsuki , Yamada Daiki , Koide Yoko , Yamada Mayumi , Shimada Yasuhiro , Yamazoe Eriko , Ito Takaaki , Tahara Kohei
Published: November 2022

To improve the powder properties of active pharmaceutical ingredients (APIs), we coated APIs with silica nanoparticles using a dry process that allowed for direct compression into tablets. The dry coating performed with different apparatuses (a batch-type high-speed shear mixer (Mechanomill) and a continuous conical screen mill (Comil)) and properties of the resulting dry-coated APIs were compared. Ethenzamide (ETZ), which has low powder flowability, was selected as the host particle to be improved and the colloidal silicas Aerosil 200 and R972 were used as the guest particles. Both coating processes and types of silica nanoparticles improved the powder flowability (angle of repose) of ETZ under unstressed conditions. Inverse gas chromatography demonstrated that dry coating with silica nanoparticles reduced the surface free energy and improved the homogeneity of the surface energy distribution of ETZ particles. Under the stress conditions of a shear cell test, the Mechnomill-based treatment improved the powder flowability of ETZ from that of untreated ETZ; however, the Comil-based treatment did not improve the flowability. The mechanical shear force exerted by Comil was apparently insufficient for interactions between host and guest particles. However, the properties of tableted ETZ were enhanced even when the silica nanoparticles were coated using Comil.
Fermentation Wastes from Chrypthecodinium cohnii Lipid Production for Energy Recovery by Anaerobic Digestion
Authors: Eusébio Ana , Moniz Patrícia , Lopes da Silva Teresa , Marques Isabel Paula
Published: November 2022

Wastes generated during the cultivation of marine microalga Crypthecodinium cohnii and after the lipid extraction process, were energetically valorized into biogas production through anaerobic digestion (AD). The tested wastes were extracted microalgae (Ae) with hexane (AeH) using supercritical extraction methods (AeS) and the supernatant obtained after culture medium centrifugation (M). The digestion of the algae biomass in the admixture with the supernatant medium (AeH+M+I and AeS+M+I) provided a higher methane content and a higher methane yield (582 and 440 L CH4/kg VS) than the substrates Ae and M, individually digested (155 and 96 L CH4/kg VS, respectively). Flow cytometry monitoring processes during AD indicated that the yield of the accumulated biogas was influenced by the operating conditions. The mixture of AeH+M+I was the only assay with a proportion of cells with less damaged membranes after AD, providing the highest methane yield and productivity (582 L CH4/kg VS and 31 L CH4/kg VS.d, respectively) and the highest energetic potential of 5.8 KWh/kg VS of all the substrates. From the results, AD integration to lipid production by C. cohnii to recover energy from the generated wastes enhanced the sustainability of the entire process and promoted the practice of zero waste.
Are Plants Capable of Pheomelanin Synthesis? Gas Chromatography/Tandem Mass Spectrometry Characterization of Thermally Degraded Melanin Isolated from Echinacea purpurea
Authors: Kurkiewicz Slawomir , Marek Łukasz , Kurkiewicz Małgorzata , Kurkiewicz Adam , Dzierżęga-Lęcznar Anna
Published: November 2022

Echinacea is a widely used plant medicine, valued especially for its well-documented ability to stimulate the immune system. It has been suggested that melanin could be one of the bioactive factors responsible for the immunostimulatory properties of the plant. The biological functions of melanin pigments are closely related to their chemical composition and structural features. The aim of this study was to characterize the melanin from Echinacea purpurea based on the analysis of thermal degradation products of the well-purified pigment extracted from the dried herb. The melanin was pyrolyzed, and the resulting products were separated by gas chromatography and identified using a triple quadrupole mass spectrometer operating in full scan and multiple reaction monitoring modes. Three groups of marker products were detected in the melanin pyrolysate: polyphenol derivatives, nitrogen-containing heterocycles devoid of sulfur, and benzothiazines/benzothiazoles. This suggests that E. purpurea produces three structurally different melanin pigments: allomelanin, eumelanin, and pheomelanin, which in turn may affect the biological activity of the herb. Our results provide the first-ever evidence that plants are capable of synthesizing pheomelanin, which until now, has only been described for representatives of the animal and fungal kingdoms.
Analysis of the Corrosion Process with the Application of the Novel Type of Coupon Installation
Authors: Musik Daniel , Wójcik Krzysztof , Sekuła-Wybańska Małgorzata , Konopacki Maciej , Rakoczy Rafał
Published: November 2022

The corrosion process leads to high power consumption, high maintenance costs and the loss of commercial income during downtime in various branches of industry. The proper methods to measure and forecast the corrosion process would help intervene in process production where corrosion is a common phenomenon. Therefore, the main aim of this experimental study is to improve the widely used corrosion monitoring methods with corrosion coupons. As part of this work, the installation for testing corrosion process under controlled conditions and with the application of mild steel coupons is proposed. The measurement concept is to install the coupons in a stream with the corrosion liquid (these conditions should be controlled). The numerical simulations of the fluid flow in the coupon installation were carried out, and the obtained results in the form of a velocity map allowed us to propose the placement of the coupons in the tested installation in such a way that the flowing liquid evenly washed the coupon surface. The developed coupon installation was tested for aggressive corrosive conditions, which were assessed using the water stability indices (Langelier Saturation Index and Ryznar stability index). Moreover, the inductively coupled plasma optical emission spectroscopy analysis characterised the liquid samples from the tested coupon installation. The corrosion process for the applied conditions was defined based on the corrosion rate of the tested coupons. This process was also confirmed by obtaining the Raman spectrum for the used corrosion coupons. The obtained investigation contributes significantly by developing the novel coupon installation and demonstrating the procedure for testing the corrosion process with the application of coupons. This setup and method might be successfully applied for accelerated laboratory tests.
Estimation of Pollution Levels and Assessment of Human Health Risks from Potentially Toxic Metals in Road Dust in Mymensingh City of Bangladesh
Authors: Kabir Md Humayun , Rashid Md Harun , Wang Qingyue
Published: November 2022

The assessment of toxic metals pollution in road dust in Mymensingh city, Bangladesh and its impact on the health risk of human exposure to toxic metals, is inadequate. A comprehensive investigation was conducted in different land use areas, i.e., commercial areas (CA), medically facilitated areas (MFA), residential areas (RA), and park areas (PA), to determine levels of Cr (chromium), Mn (manganese), Ni (nickel), Co (cobalt), Cu (copper), Zn (zinc), As (arsenic), Cd (cadmium), and Pb (lead) using inductively coupled plasma mass spectroscopy (ICP-MS). We planned to use different pollution indices, such as the geoaccumulation index (Igeo), contamination factor (CF), degree of contamination (Cdeg), ecological risk (Er), pollution load index (PLI), and enrichment factor (EF), to measure the level of contamination in the road dust of Mymensingh City. The average concentration (mg/kg) ranges of toxic metals in the road dust at different land use areas of Mymensingh City were: Cr (40.8–85.5), Mn (370.7–589.2), Co (6.2–8.7), Ni (22.7–34.2), Cu (29.5–72.2), Zn (236.2–467.1), As (4.9–6.29), Cd (0.32–1.07), and Pb (27.4–81.7), respectively. The CF and PLI results showed that the road dust in these zones was contaminated with toxic metals. The indicator Igeo revealed that CA was found to be ‘moderately to heavily contaminated’ ranked with Zn and Cd. Calculation of EF indicated that Cu, Zn, As, Cd, and Pb were highly enriched, while others were moderately enriched. According to the Cdeg findings, CA, MFA, and RA have very high degrees of contamination (Cdeg ≥ 24), while PA was classified as having a considerable degree of contamination (12 ≤ Cdeg < 24). The Er index showed that only Cd posed a ‘medium potential ecological risk’ to a ‘high ecological potential risk’ in road dust. The most common route of exposure was ingestion. The study indicated that the hazard quotient (HQ) and hazard index (HI) in CA, MFA, RA, and PA were less than one for children and adults, which were at a noncarcinogenic risk. The only exception was for children exposed to manganese (HI > 1) in all land use areas. In the research area, no significant carcinogenic health risk was observed for Cr, Ni, As, Cd, and Pb.
Natural Hallucinogens in Mental Health
Authors: Santos Rafael Guimarães Dos , Hallak Jaime Eduardo Cecilio
Published: November 2022

In the last two decades, an increasing trend has unfolded toward the possible beneficial uses of natural hallucinogenic substances for treating mental health disorders [...]
The Sacred Writing of Knowledge: Interpreting the True Form Charts of the Man-Bird Mountain in Taoism
Authors: Cai Linbo
Published: November 2022

The True Form Charts of the Man-Bird Mountain (人鳥山真形圖, or TFCMBM) are important ritual images created by ancient Taoists. Scholars envisage them as the “fairy mountain map” (仙山圖) or “fairyland picture” (仙境圖) imagined by ancient Taoists. However, TFCMBM is actually a description of the mechanism of the “convergence of celestial and terrestrial qi”(天地氣交) in the human body. According to ancient Chinese medicine, the mechanism of the inter-induction of qi (氣交) controls the transmission and transformation of food, circulation of qi-blood in the body, and generation and storage of vital essence. Ancient Taoist priests referred to the mechanism of the inter-induction of qi as “regulating qi in Central Yellow” (黃中理炁) and as a kind of image, “the true shape of the human bird mountain” to guide novice Taoists in meditation (存思) and activating qi (行氣). This study argues that the TFCMBM is a portrayal of the mechanism of the inter-induction of qi and reveals the Taoist method of writing sacred knowledge and its cognitive nature.
Correction: Moghimi et al. Automatic Relative Radiometric Normalization of Bi-Temporal Satellite Images Using a Coarse-to-Fine Pseudo-Invariant Features Selection and Fuzzy Integral Fusion Strategies. Remote Sens. 2022, 14, 1777
Authors: Moghimi Armin , Mohammadzadeh Ali , Celik Turgay , Brisco Brian , Amani Meisam
Published: November 2022

There was an error in the original publication [...]
Modeling and Analysis of Microwave Emission from Multiscale Soil Surfaces Using AIEM Model
Authors: Yang Ying , Chen Kun-Shan , Jiang Rui
Published: November 2022

Natural rough surfaces have inherent multiscale roughness. This article presents the modeling and analysis of microwave emission from a multiscale soil surface. Unlike the linear superposition of different correlation functions with various correlation lengths, we applied the frequency modulation concept to characterize the multiscale roughness, in which the modulation does not destroy the surface’s curvature but only modifies it. The multiscale effect on emission under different observation geometries and surface parameters was examined using an AIEM model. The paper provides new insights into the dependence of polarized emissivity on multiscale roughness: V-polarized emissivity is much less sensitive to multiscale roughness across the moisture content from dry to wet (5–30%). The H-polarized is sensitive to multiscale roughness, especially at higher moisture content. The predicted emissivity will have considerable uncertainty, even for the same baseline correlation length, without accounting for the multiscale roughness effect. V-polarized emissivity is less sensitive to the multiscale effect than H-polarized and the higher modulation ratio indicates larger emissivity. The higher modulation ratio indicates larger emissivity. Multiscale roughness weakens the polarization difference, particularly in higher moisture conditions. In addition, ignoring the multiscale effect leads to underestimated emissivity to a certain extent, particularly at the larger RMS height region. Finally, when accounting for multiscale roughness, model predictions of emission from a soil surface are in good agreement with two independently measured data sets.
Comparing Different Light Use Efficiency Models to Estimate the Gross Primary Productivity of a Cork Oak Plantation in Northern China
Authors: Liu Linqi , Gao Xiang , Cao Binhua , Ba Yinji , Chen Jingling , Cheng Xiangfen , Zhou Yu , Huang Hui , Zhang Jinsong
Published: November 2022

Light use efficiency (LUE) models have been widely used to estimate terrestrial gross primary production (GPP). However, the estimation of GPP still has large uncertainties owing to an insufficient understanding of the complex relationship between water availability and photosynthesis. The plant water stress index (PWSI), which is based on canopy temperature, is very sensitive to the plant stomatal opening and has been regarded as a good indicator for monitoring plant water status at the regional scale. In this study, we selected a cork oak plantation in northern China with an obvious seasonal drought as the research object. Using the ground-observed data, we evaluated the applicability of the LUE models with typical water stress scalars (MOD17, MODTEM, EC-LUE, ECM-LUE, SM-LUE, GLO-PEM, and Wang) in a GPP simulation of the cork oak plantation and explored whether the model’s accuracy can be improved by applying PWSI to modify the above models. The results showed that among the seven LUE models, the water stress scalar had a greater impact on the model’s performance than the temperature stress scalar. On sunny days, the daily GPP simulated by the seven LUE models was poorly matched with the measured GPP, and all models explained only 23–52% of the GPP variation in the cork oak plantation. The modified LUE models can significantly improve the prediction accuracy of the GPP and explain 49–65% of the variation in the daily GPP. On cloudy days, the performance of the modified LUE models did not improve, and the evaporative fraction was more suitable for defining the water stress scalar in the LUE models. The ECM-LUE and the modified GLO-PEM based on PWSI had optimal model structures for simulating the GPP of the cork oak plantation under cloudy and sunny days, respectively. This study provides a reference for the accurate prediction of GPP in terrestrial ecosystems in the future.
Wideband Versatile Receiver for CubeSat Microwave Front-Ends
Authors: Cardillo Emanuele , Cananzi Renato , Vita Paolo
Published: November 2022

One of the main features of CubeSats is represented by their extreme versatility, e.g., maintaining the same overall structure for different purposes. This requires high technological flexibility achievable in a cost-effective way while maintaining compact sizes. In this contribution, a microwave receiver specifically designed for CubeSat applications is proposed. Due to the wide input operating bandwidth, i.e., 2 GHz–18 GHz, it can be exploited for different purposes, e.g., satellite communication, radars, and electronic warfare systems. This is beneficial for CubeSat systems, whereby the possibility to share the same front-end circuit for different purposes is a key feature in reducing the overall size and weight. The downconverter was designed to minimize the spurious contributions at low frequency by taking advantage, at the same time, of commercial off-the-shelf components due to their cost-effectiveness. The idea behind this work is to add flexibility to the CubeSat communication systems in order to be reusable in different contexts. This feature enables new applications but also provides the largest bandwidth if required from the ground system. An accurate experimental characterization was performed to validate the downconverter performance with the aim of allowing easy system integration for the new frontier of CubeSat technologies. This paves the way for the most effective implementation of the Internet of Things (IoT), machine-to-machine (M2M) communications, and smart-everything services.
Realization of Crowded Pipes Climbing Locomotion of Snake Robot Using Hybrid Force–Position Control Method
Authors: Wang Yongdong , Kamegawa Tetsushi
Published: November 2022

The movement capabilities of snake robots allow them to be applied in a variety of applications. We realized a snake robot climbing in crowded pipes. In this paper, we implement a sinusoidal curve control method that allows the snake robot to move faster. The control method is composed of a hybrid force–position controller that allows the snake robot to move more stably. We conducted experiments to confirm the effectiveness of the proposed method. The experimental results show that the proposed method is stable and effective compared to the previous control method that we had implemented in the snake robot.
Explainable AI Algorithms for Vibration Data-Based Fault Detection: Use Case-Adadpted Methods and Critical Evaluation
Authors: Mey Oliver , Neufeld Deniz
Published: November 2022

Analyzing vibration data using deep neural networks is an effective way to detect damages in rotating machinery at an early stage. However, the black-box approach of these methods often does not provide a satisfactory solution because the cause of classifications is not comprehensible to humans. Therefore, this work investigates the application of the explainable AI (XAI) algorithms to convolutional neural networks for vibration-based condition monitoring. Thus, the three XAI algorithms GradCAM, LRP and LIME with a modified perturbation strategy are applied to classifications based on the Fourier transform as well as the order analysis of the vibration signal. The following visualization as frequency-RPM maps and order-RPM maps allows for an effective assessment of saliency values for variable periodicity of the data, which translates to a varying rotation speed of a real-world machine. To compare the explanatory power of the XAI methods, investigations are first carried out with a synthetic data set with known class-specific characteristics. Both a visual and a quantitative analysis of the resulting saliency maps are presented. Then, a real-world data set for vibration-based imbalance classification on an electric motor, which runs at a broad range of rotation speeds, is used. The results indicate that the investigated algorithms are each partially successful in providing sample-specific saliency maps which highlight class-specific features and omit features which are not relevant for classification.
How Did COVID-19 Pandemic Impact Safety Performance on a Construction Project? A Case Study Comparing Pre and Post COVID-19 Influence on Safety at an Australian Construction Site
Authors: Selleck Roberta , Cattani Marcus , Hassall Maureen
Published: November 2022

COVID-19 had a significant impact on construction projects due to labor shortages and COVID-19 restrictions, yet little is known about the impact it had on construction safety. To address this gap, an Australian construction project was selected to study the impact of COVID-19 on safety performance, safety climate and safety leadership. The study collected data from safety climate surveys, leading and lagging safety indicators and used linear regression to compare safety performance pre and post the onset of COVID-19. Our results showed after the onset of COVID-19 there was a significant reduction (Pr > F at 0.05%) in incident rate, an improvement in supervisor safety leadership and safety climate, and satisfaction with organisational communication. The study identified the increase level of safety awareness due to COVID-19 did not result in an increase in the level of engagement in safety leadership. Interestingly, participation in the safety leadership activities did not improve until a change of Project Manager occurred. The study determined leaders who establish a positive safety climate within a project could negate the safety performance impact of COVID-19. The study confirms the importance of site safety leadership in maintaining engagement in risk management and the value of focused safety communication.
An Inquiry into Bhutanese Agriculture Research–Practice Gaps Using Rogers Innovation Adoption Attributes and Mode 2 Knowledge Production Features
Authors: Dorji Kinley , Miller Judith , Wu Shubiao
Published: November 2022

Investigation into the relevance and utility of bridging gaps between knowledge and practice is necessary to justify such endeavors to public funding agencies. This study investigated the underlying causes of the research–practice gap in the Bhutanese context with the aim to realign the relevance of agricultural research and to enhance practice using Rogers innovation attributes on features of Mode 2 knowledge production features. Out of 233 articles published by three agricultural journal publishers, only 110 articles that met our criteria were included in this study. Principal component analysis (PCA) for 23 variables yielded five variables that contributed 90% of the total variation. The first two dimensions contained 39.34% of the total dataset inertia, which was significantly greater than the reference value (17.19%) obtained by simulating 959 data tables of equivalent size based on a normal distribution. Further, cluster analysis differentiated the observations into three distinct clusters that significantly differed in their variable descriptive values. The innovation attributes ‘complexity’ and ‘compatibility’ received the highest score, while ‘observability’ had the lowest score. Under innovation diffusion elements, ‘time’ and ‘social system’ aspects were the least considered, thus affecting the innovation adoption. The ‘context of application’ of innovation had the highest score (65%), whereas ‘diffusion’ of the knowledge under transdisciplinarity received the lowest score. Both the diversity of ‘discipline’ and ‘organization’ inclusion under heterogeneity received the lowest score. Informal communication and social dimension received the lowest score among the Mode 2 knowledge production variables. Bhutan followed conventional, linear, and unidirectional approaches to research and extension diffusion systems, by which research institutions innovate, and extension workers bring innovation to potential adopters. Bhutanese research policy and strategy must consider reframing relevant agriculture innovation systems to keep abreast of modern technology development.
Research on the Effect of Particle Size on the Interface Friction between Geogrid Reinforcement and Soil
Authors: Zhao Yunfei , Yang Guangqing , Wang Zhi , Yuan Shaopeng
Published: November 2022

For projects such as roads and railways, different fillers are often selected, and these also relate to the area where the project is located, so the characteristics of the filling soil should be considered in the design. However, the characteristics of the soil used in geosynthetic-reinforced soil (GRS) structure design are routinely simple soil properties and are not based on testing of soil with reinforcement. In order to study the influence of fillers with different particle sizes on the interface friction characteristics between the geogrid and soil, a self-developed large-scale pull-out testing machine was used. Under the action of a normal static load, pull-out tests were carried out with different fillers, such as sand, silt and gravel. According to the test results, the greater the stress applied in the normal direction, the greater the maximum pull-out force. As for the different fillers, shear stress from material with a larger particle size, such as gravel, was larger than that of sand and silt. Finally, to reveal the pattern of how the soil particles moved during the pull-out test, from a microscopic point of view, and the effect on particle–mesh size ratio, a series of discrete element method (DEM) analyses were conducted by PFC2D. The results indicated that a larger particle is more likely to rotate and move during the test, and this makes the interlocking effect greater between the geogrid and the soil, which leads to a larger pull-out force in the laboratory test.