bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pelarut Terhadap Reaksi Penataan Ulang Claisen dan Siklisasi Senyawa Alil 1-Naftil Eter dengan Metode Microwave Assisted Organic Synthesis (MAOS)
Authors: Pramesti Indah Nur , Okada Yutaka
Published: September 2022

Reaksi penataan ulang Claisen merupakan salah satu reaksi penting untuk pembentukan ikatan baru karbon-karbon dalam sintesis organik. Secara umum, reaksi penataan ulang Claisen hanya dapat berlangsung dalam kondisi reaksi yang cukup ekstrim yaitu suhu yang tinggi 180-225oC dengan waktu yang lama. Dalam penelitian ini dilakukan sintesis alil 1-naftil eter terlebih dahulu melalui reaksi substitusi gugus alil pada senyawa 1-naftol dengan pemanasan pada suhu 58oC selama 8 jam. Produk reaksi alilasi dianalisis kemurniannya dengan menggunakan HPLC dan H-NMR. Selanjutnya, reaksi penataan ulang Claisen pada senyawa hasil sintesis alil 1-naftil eter berhasil dilakukan pada suhu reaksi yang rendah dan waktu yang singkat menggunakan metode Microwave Assisted Organic Synthesis(MAOS) dan katalis FeCl3. Karakterisasi menggunakan GC-MS menunjukkan senyawa yang terbentuk adalah 2-alil-1-naftol (produk penataan ulang Claisen), 2-metil-2,3-dihidronaftofuran (produk siklisasi) dan 1-naftol sebagai produk balik. Hasil penelitian menunjukkan bahwa reaksi penataan ulang Claisen dan siklisasi pada senyawa alil 1-naftil eter berlangsung optimum dengan menggunakan pelarut 1,2-dikloroetana pada suhu 80oC selama 20 menit dengan radiasi microwave.
Karakteristik dan Aktivitas Antibakteri pada Edible Film Berbasis Pati Ubi Kayu dengan Penambahan Minyak Cengkeh
Authors: Wijaya Aprisilia Risky
Published: September 2022

Kesadaran konsumen terhadap makanan berkualitas dan ramah lingkungan semakin tinggi. Beberapa penelitian telah mengembangkan produk pengemas yang edible dan aktif. Penelitian ini bertujuan untuk menghasilkan edible film yang memiliki aktivitas antibakteri. Pembuatan edible film pada penelitian ini menggunakan bahan dasar pati yang diekstrak dari ubi kayu. Bahan tambahan yang digunakan yaitu Carboxymethyl cellulose, gliserol dan minyak cengkeh. Variasi konsentrasi minyak cengkeh yang digunakan yaitu 1%, 2% dan 3%. Berdasarkan analisis Gas Chromatography-Mass Spectra (GC-MS), komponen utama dari minyak cengkeh adalah eugenol. Eugenol berperan terhadap aktivitas antibakteri pada edible film. Semakin tinggi konsentrasi minyak cengkeh, semakin tinggi daya hambat bakteri. Edible film dengan penambahan minyak cengkeh 3% memiliki daya hambat bakteri yang tertinggi yaitu 8,5 mm untuk bakteri Escherichia coli dan 11,3 mm untuk bakteri Staphylococcus aureus. Tingkat kelarutan edible film menurun seiring dengan penambahan minyak cengkeh yaitu 78,77%-39,38%. Penambahan minyak cengkeh pada pembuatan edible film berbasis pati mampu menghambat pertumbuhan bakteri Staphylococcus aureus dan Eschericia coli. Namun, semakin tinggi penambahan minyak cengkeh akan menurunkan tingkat kelarutan edible film.
International Production and Trade in the IC Industry Based on Complex Network SNA under COVID-19
Authors: Teng Chunnan , Lien Yungchih , Chen Homin
Published: September 2022

Social network analysis (SNA) is an effective method for characterizing networks from various specific perspectives. Global trade contracted sharply in 2020 owing to the COVID-19 pandemic, and growth is expected to be lower than the pre-pandemic trends. This study takes countries worldwide as the primary unit of analysis and uses different procedures of social network analysis (SNA), including network density, centrality, and core-periphery structure, and applies them to the field of trade in electronic integrated circuit products (ICPT). In addition to static and descriptive analysis, this study also uses of tools such as Ucinet 6.732 for visual analysis, visual analysis, and more convenient and precise display of the network structure of ICPT. The important countries play a central role in determining the overall structural features. The core-periphery structure in the network from both spatial and temporal perspectives, data on electronic integrated circuit products for the period 2015-2021 were used in SNA. This study found that the ICPT network became denser from 2015 to 2021 but declined and picked up in 2018 and 2020. Moreover, the core-peripheral structure exists in the ICPT network. The main core network countries are Taiwan, Hong Kong, Singapore, mainland China, Malaysia, Japan, the Philippines, Thailand, Vietnam, and other Asian countries, including the United States and Germany.
Iterative Qubits Management for Quantum Search
Authors: Mu Wenrui
Published: September 2022

Recent advances in quantum computing systems attract tremendous attention. Commercial companies, such as IBM, Amazon, and IonQ, have started to provide access to noisy intermediate-scale quantum computers. Researchers and entrepreneurs attempt to deploy their applications that aim to achieve a quantum speedup. Grover’s algorithm and quantum phase estimation are the foundations of many applications with the potential for such a speedup. While these algorithms, in theory, obtain marvelous performance, deploying them on existing quantum devices is a challenging task. For example, quantum phase estimation requires extra qubits and a large number of controlled operations, which are impractical due to low-qubit and noisy hardware. To fully utilize the limited onboard qubits, we develop a distributed application with a key-value data structure based on Grover’s algorithm called IQuCS . Consider a database with duplicates. By encoding each element to a binary type with a unique key and forming a key-value pair, we can count the number of occurrences of each element in the database based on quantum computing. We have optimized the operation process by filtering data points to make it more efficient. To determine the effect of this optimization, we evaluate it with datasets of different sizes and with different numbers of duplicates. With the assistance of classical computers, IQuCS can reduce the problem set for each query. Due to this reduction, IQuCS requires fewer qubits. Through the iterative management, IQuCS achieves a reduction of qubit virtualized consumption, up to 66.2%, with reasonable accuracy.
Penanganan Jalan Berdasarkan Umur Sisa Perkerasan dan Internatioanl Roughness Index (IRI) pada Ruas Jalan Nasional Simpang Kayu Ara - Batas Kabupaten Pelalawan Provinsi Riau
Authors: Putra Benny Hamdi Rhoma , Alwinda Yosi , Yogi Yogi , Elianora Elianora
Published: September 2022

Jalan nasional merupakan jalan yang digunakan sebagai penghubung antar daerah dengan kapasitas dan lajur jalan yang besar, sehingga dapat menunjang dan meningkatkan pertumbuhan ekonomi masyarakat. Jalan nasional Simpang Kayu Ara – Batas Kebupaten Pelalawan merupakan satu satunya akses masuk ke Kota Pekanbaru dari Provinsi Jambi. Penelitian ini bertujuan untuk mengetahui kondisi dan jenis preservasi jalan yang ada di ruas jalan nasional Simpang Kayu Ara – Batas Kebupaten Pelalawan. Adapun panjang segmen jalan ini adalah 3,6 Km. Penelitian ini menggunakan metode kuantitatif berdasarkan data sekunder dari Balai Pelaksanaan Jalan Nasional Provinsi Riau. Parameter yang digunakan dalam menentukan jenis kegiatan preservasi jalan adalah nilai Remaining Structural Life (RSL) dan International Roughness Index (IRI). Melalui penelitian ini didapatkan kondisi dan jenis preservasi ruas jalan nasional Simpang Kayu Ara – Batas Kabupaten Pelalawan bahwa nilai IRI adalah 82,86% dalam kondisi sedang, 17,14% rusak ringan. Adapun kebutuhan akan kegiatan preservasi pada jalan ini sebanyak 68,57% bagian jalan memerlukan perawatan rutin, 11,43% memerlukan structural overlay dan 20% jalan memerlukan rekonstruksi.
A New Multi-Objective Comprehensive Optimization Model for Homogeneous Slope Reinforced by Anti-Slide Piles: Insights from Numerical Simulation
Authors: Xu Chao , Xue Lei , Cui Yuan , Guo Songfeng , Zhai Mengyang , Bu Fengchang
Published: September 2022

Landslides have posed a huge threat to the ecological environment and human society all over the world. As the most conventional reinforcement method, anti-slide piles are widely used in the reinforcement of slopes. Currently, more and more attention has been paid to the low-cost and high-efficiency optimal design of anti-slide piles. However, limitations in the method of the optimization design for slopes reinforced with piles still exist. In this paper, a new multi-objective comprehensive optimization method was proposed for the optimization of the slope reinforced with anti-slide piles. The factor of safety, internal force, and deflection of piles were selected as the optimization indexes, and the optimization index weight was determined by integrating the subjective and objective weights. The influence of pile locations, pile lengths, and pile spacings on the reinforcement effect of a homogeneous slope was analyzed via the numerical simulation. Through the simulation case analysis, the proposed model had achieved good effects on the optimization design of anti-slide piles, which could effectively reduce the engineering costs. The optimization results showed that the best reinforcement effect for the homogeneous slope could be obtained when the anti-slide piles with the critical pile length and small pile spacing were located in the middle of the slope. This provides a new solution for the optimization design of other types of complex slopes and has broad application prospects.
Application of quantitative decision-making tools in planning for seasonal variations of fever cases reporting at the medical emergency of a tertiary care hospital in New Delhi
Authors: Sharma Nishant , Madaan Nirupam , Gupta Anant
Published: September 2022

Background
The healthcare industry of today is defined by patient centricity, perishability, intangibility and heterogenicity. Healthcare managers are faced with a challenge to maximize results by utilizing minimum resources. Forecasting is one of the techniques that help them in planning services. However, the accuracy of the forecast depends on multiple factors such as time horizon, the technique that is applied and certain irregular variations, which may be beyond the control of managers.
Methods
A retrospective record analysis was done to analyze trends in the monthly footfall in the emergency. Forecasting techniques were applied to predict the number of fever cases that were expected during a particular time period, based on which, the quantum of supplies needed was calculated using linear programming model. The actual and predicted number of patients that visited the emergency for 4 years was tabulated.
Results
It was observed that the demand for different consumables increased by 33–200% during the peak season. The Mean Absolute Deviation (MAD) was calculated to be 3981.22, Mean Absolute Percentage Error (MAPE) was 30.17% and the Tracking Signal varied between − 1.78 and + 0.86 which indicates that the forecast method was fairly accurate.
Conclusion
The same method may be applied to forecast the number of patients and accordingly the quantum of resources required for their management.
Study protocol for implementing videorecording of acute neonatal interventions to create reflexivity; the Neoflix project
Authors: Heesters Veerle , Zanten Henriette A van , de Boer Linsey CC , Visser Remco , Heijstek Veerle , Pas Arjan B te , Witlox Ruben SGM
Published: September 2022

Purpose: The environment of the NICU can be dynamic and emergent. Video-reflection of neonatal interventions gives an objective view on clinical practice. Although video-reflection is increasingly used, it is focused mostly on technical aspects. The focus of video-reflection can also be shifted towards teamwork and context. However, no studies have explained the set-up for video-reflexive sessions of neonatal interventions and how to use it to drive change and improvement neonatal interventions. We aim to identify success factors and prerequisites for implementation of video-reflexivity and to create a manual for other departments.
Methods: video-reflexive sessions will be conducted at the NICU of the LUMC. Interventions that are recorded include 1) line insertions, 2) intubations and MIST procedures and 3) neonatal resuscitations at birth. Caregivers can choose to record interventions they perform, are offered the option of reviewing the recordings and are invited to attend the multidisciplinary reflexive sessions. Observations regarding insights, ideas and discussions will be evaluated. Action-research will be performed to make improvements in neonatal care based.
Results and conclusion: Institutional research ethics approval has been acquired. Results will be published in peer-reviewed journals and presented at relevant conferences. Findings will be presented to caregivers to inform them of ongoing improvements of neonatal interventions. Time is limited in an acute care department, not all caregivers can attend each session. We distribute findings from the reflexive sessions among all caregivers. Our proposal is based on the experience of a single center level III NICU.
Blastocystis sp. reduces chemotherapeutic potency of 5- fluorouracil against colorectal cancer
Authors: KUMARASAMY VINOTH , Kuppusamy Umah Rani , Jayalakshmi Pailoor , Govind Suresh Kumar
Published: September 2022

Blastocystis is an enteric protozoan parasite with extensive genetic variation and unclear pathogenicity. It is commonly associated with gastrointestinal symptoms in immunocompromised individuals including colorectal cancer (CRC) patients. In this study, we explored the in vitro and in vivo effects of Blastocystison the activity of a commonly used CRC chemotherapeutic agent, 5-FU. The cellular and molecular effects of solubilized antigen of Blastocystisin the presence of 5-FU were investigated using HCT116, human CRC cell line and CCD 18-Co, normal human colon fibroblast cells. For the in vivo study, 30 male Wistar rats were divided into six groups, as follows; Control Group: oral administration of 0.3ml Jones' medium, Group A: rats injected with azoxymethane (AOM), Group A-30FU: Rats injected with AOM and administered 30mg/kg 5-FU, Group B-A-30FU: rats inoculated with Blastocystis cysts, injected with AOM and administered 30mg/kg 5-FU, Group A-60FU: rats injected with AOM and administered 60mg/kg 5-FU and Group B-A-60FU: rats inoculated with Blastocystis cysts, injected with AOM and administered 60mg/kg 5-FU. The in vitro study revealed that the inhibitory potency of 5-FU at 8µM and 10µM was reduced from 57.7% to 31.6% (p<0.001) and 69.0% to 36.7% (p<0.001) respectively when co-incubated with Blastocystis antigen for 24 hours. However, the inhibitory potency of 5-FU in CCD-18Co cells was not significantly affected in the presence of Blastocystis antigen. The reduced inhibitory potency of 5-FU against cancer cell proliferation due to the presence of Blastocystis is consistent with the upregulation of expression of type 2 cytokines, transforming growth factor (TGF-β) and nuclear factor E2-related factor 2 (Nrf2) gene expression. An increased inflammation and abnormal histopathological findings along with a significant cancer multiplicity and adenoma incidence were evident in the intestine of the B-A-30FU and B-A-60FU groups when compared with the A-30FU and A-60FU groups respectively. Our in vitro and in vivo findings indicate that Blastocystis infection could potentially interfere with chemotherapy regimens such as 5-FU in CRC patients undergoing chemotherapy.
Clinical impact of cardiac magnetic resonance in patients with suspected coronary artery disease associated with chronic kidney disease (AQUAMARINE-CKD study): study protocol for a randomized controlled trial
Authors: Noguchi Teruo , Ota Hideki , Matsumoto Naoya , Morita Yoshiaki , Oshita Akira , Kawasaki Eiji , Kawasaki Tomohiro , Moriwaki Kensuke , Kato Shingo , Fukui Kazuki , Hoshi Tomoya , Watabe Hiroaki , Kanaya Tomoaki , Asaumi Yasuhide , Kataoka Yu , Otsuka Fumiyuki , Takagi Kensuke , Yoneda Shuichi , Sawada Kenichiro , Iwai Takamasa , Matama Hideo , Honda Satoshi , Fujino Masashi , Miura Hiroyuki , Nishimura Kunihiro , Takase Kei
Published: September 2022

Background
Although screening for coronary artery disease (CAD) using computed tomography coronary angiography in patients with stable chest pain has been reported to be beneficial, patients with chronic kidney disease (CKD) might have limited benefit due to complications of contrast agent nephropathy and decreased diagnostic accuracy as a result of coronary artery calcifications. Cardiac magnetic resonance (CMR) has emerged as a novel imaging modality for detecting coronary stenosis and high-risk coronary plaques without contrast media that is not affected by coronary artery calcification. However, clinical use of this technology has not been robustly evaluated.
Methods
AQUAMARINE-CKD is an open parallel-group prospective multicenter randomized controlled trial of 524 patients with CKD at high risk for CAD estimated based on risk factor categories for a Japanese urban population (Suita score) recruited from 6 institutions. Participants will be randomized 1:1 to receive CMR examination that includes non-contrast T1-weighted imaging and coronary magnetic angiography (CMR group) or standard examinations that include stress myocardial scintigraphy (control group). Randomization will be conducted using a web-based system to ensure allocation concealment and incorporate minimization. The primary outcome is a composite of death from CAD, all-cause death, nonfatal myocardial infarction, nonfatal ischemic stroke, ischemia-driven unplanned coronary intervention (percutaneous coronary intervention, coronary bypass surgery, or hospitalization for unstable angina pectoris).
Discussion
This is the first study to look at the implementation of CMR in an outcome-focused patient care pathway. This study will have major implications for the management of patients with CKD at high risk for CAD.
Trial registration:
Japan Registry of Clinical Trials (jRCT) number 1052210075. Registered on September 10, 2021, http://apps.who.int/trialsearch/ListBy.aspx?TypeListing=0
Type of adjuvant endocrine therapy and disease-free survival in patients with early HR-positive/HER2-positive BC: analysis from the phase III randomized ShortHER trial
Authors: DIECI MARIA VITTORIA , BISAGNI GIANCARLO , BARTOLINI STEFANIA , FRASSOLDATI ANTONIO , VICINI ROBERTO , BALDUZZI SARA , D’AMICO ROBERTO , CONTE PIERFRANCO , GUARNERI VALENTINA
Published: September 2022

Background
We evaluated the impact of the type of endocrine therapy on disease-free survival (DFS) in patients with HR-positive/HER2-positive BC enrolled in the phase III ShortHER trial.
Methods
Short-HER randomized 1254 patients with HER2-positive early BC to 9 weeks vs 1 year of adjuvant trastuzumab combined with anthracycline-taxane chemotherapy. The type of adjuvant endocrine was collected during the first 5 years of follow-up and was classified as: aromatase inhibitor (AI), tamoxifen and aromatase inhibitor (TAM-AI), or tamoxifen (TAM). The use of gonadotropin-releasing hormone analogues (GnRHa) was also collected. DFS was calculated from randomization to disease recurrence, second primary tumor, or death.
Results
784 patients with HR-positive BC were included: 60.5% postmenopausal, median age 55 years. The pattern of endocrine therapy was: 59.6% AI, 23.8% TAM, 16.6% TAM-AI. At a median follow up of 8.7 years, patients who received AI had a significantly better DFS vs patients who received TAM or TAM-AI: 8-yr DFS 86.4% vs 79.7%, log-rank P = 0.013 (HR 1.52, 95%CI 1.09–2.11). In multivariate analysis, the type of endocrine therapy maintained a significant association with DFS (HR 1.64, 95% CI 1.07–2.52, p = 0.025 for TAM/TAM-AI vs AI). Among premenopausal patients aged ≤ 45 years (97% receiving TAM or TAM-AI), the use of GnRHa was associated with longer DFS: 8-yr DFS rate 85.2% vs 62.6% (log-rank p = 0.019, HR 0.41, 95% CI 0.19–0.88).
Conclusions
In this post-hoc analysis of the ShortHER trial adjuvant treatment with AI was independently associated with improved DFS. Subgroup analysis in young premenopausal patients suggests benefit with ovarian suppression.
Trial registration:
NCI ClinicalTrials.gov number: NCT00629278. Registered 5 March 2008. Retrospectively registered (first patient in December 2007).
Pharmacological investigation on acute and sub-acute studies of Arsenicum album in Experimental Rats
Authors: Lal Roshan , Sharma Mahima , Behera Sangita , Regar Raj Kumar , Tripathi Deepika , Kumar GV Narasimha , Singh Satvinder , Verma Digvijay , Gupta Pankaj , Kaushik Subhash , Khurana Anil
Published: September 2022

Purpose
Arsenic album in its various potencies are frequently prescribed by homoeopathic practitioners for wide range of human anomaly in everyday life. However, reports on safety and effects of Arsenic album are not available till date to support its usage. Therefore the objective of study is to evaluate the acute and subacute oral toxicity of Arsenic albumin 6C, 30C and 200C in experimental rats.
Materials and Methods
Arsenic album (6C, 30C, 200C) was administered orally at 2000 µl/kg to access acute toxicity in Wistar rats and observed for toxic signs up to 14 days. For subacute oral toxicity study, it was administered for 28 days. Animals were observed for clinical signs, change in body weights, feed intake and water intake. Hematological, biochemical, organ weight, histopathological analysis were assessed.
Results
No mortality at a dose of 2000 µl/kg of Arsenic album in acute toxicity study, which indicates that oral LD50 of arsenic album (6C, 30C, 200C) is > 2000 µl/kg. In subacute toxicity study, Arsenic album (6C, 30C, 200C) orally at 200 µl/kg did not show any significant changes in body weight, feed consumption, water intake, hematological and biochemical parameters compared to normal group. Furthermore, no pathological changes were observed in histopathology of treated rats compared to normal group.
Conclusion
Collectively, results suggest that the Arsenic album (6C, 30C, 200C) is safe and produces no toxicity when administered for prolonged duration at 200 µl/kg in Wistar albino rats.
Spinocerebellar Ataxia type 3 is rare in the Peruvian Population
Authors: Cornejo-Olivas Mario , Solis-Ponce Lesly , Araujo-Aliaga Ismael , Milla-Neyra Karina , Ortega Olimpio , Illanes-Manrique Maryenela , Mazzetti Pilar , Manrique-Enciso Carla , Cubas-Montecino Diana , Saraiva-Pereira Maria Luiza , Jardim Laura B. , Sarapura-Castro Elison
Published: September 2022

Spinocerebellar ataxia type 3 or Machado-Joseph Disease (MJD/SCA3) is the most prevalent autosomal dominant cerebellar ataxia worldwide, but its frequency varies by geographic region. We describe MJD/SCA3 patients diagnosed in a tertiary healthcare institution in Peru. In a cohort of 341 individuals with clinical ataxia diagnosis, seven MJD/SCA3 probands were identified and their pedigrees extended, detecting a total of 18(5%) MJD/SCA3 cases. Out of 682 alleles from this cohort, the 23-CAG repeat was the most common ATXN3allele (32.1%), followed by the 14-CAG repeat allele (26%). Normal alleles ranged from 12 to 38 repeats while pathogenic alleles ranged from 61-75 repeats. We identified 101 large normal (LN) alleles (14.8%). Five out of seven families declared an affected family member traced back to foreign countries (England, Japan, China, and Trinidad and Tobago). MJD/SCA3 patients showed ataxia, accompanied by pyramidal signs, dysarthria and dysphagia as well as abnormal oculomotor movements. In conclusion, ATXN3 allelic distribution in non-MJD/SCA3 patients with ataxia is similar to the distribution in normal individuals around the world, whereas LN allele frequency reinforces no correlation with the frequency of MJD/SCA3. Evidence of an abnormal MJD/SCA3 phenotype was not found. Further haplotypes are required to confirm the foreign origin of MJD/SCA3 in the Peruvian population.
Clinicopathological features and prognostic factors analysis of multiple synchronous distinct subtypes of primary thyroid carcinoma
Authors: Dai Quanwei , Fu Xinghao , Ding Yalei , He Qi , Qiu Xinguang
Published: September 2022

Purpose: To investigate the clinicopathological features, diagnosis, treatment and prognosis of multiple synchronous distinct subtypes of primary thyroid carcinomas
Methods: The clinical data of 68 cases of synchronous carcinomas of the thyroid(STC) admitted to the Department of Thyroid Surgery in our hospital from January 2013 to December 2021 were reviewed.，According to the pathological type, they were divided into the Synchronous differentiated and differentiated thyroid Carcinoma(SDDTC)group (42 cases), the Synchronous medullary and differentiated thyroid Carcinoma(SMDTC)group (18 cases), and the Synchronous Anaplastic and differentiated thyroid Carcinoma (SADTC)group (8 cases). The diagnosis, treatment and survival of patients in each group were analyzed.
Results: Women with coexisting thyroid cancer were predominant (59 cases). Most of the symptoms were found on physical examination and neck mass. In the SDDTC group, the median age of patients in the SDDTC group, SADTC group and SMDTC group was 47.5 (28-74) years old, 68.5 (26-75) years old, and 56.5 (39-74) years old. The age of the SADTC group and SMDTC group was older than that of the SDDTC group (P=0.04, P=0.03), and lymph node metastasis was more likely to occur (P=0.02, P<0.01).The disease course time, tumor location, clinical stage, and mortality of the SADTC group were significantly different from those of the SDDTC group and SMDTC survival was 38.5 months. The tumor-free survival was 0-90 months, 19.1% of patients developed distant metastasis, 11.8% of patients had postoperative recurrence, and the survival rate was 91.18%. Cox model multivariate analysis showed that cervical lateral lymph node metastasis and tumor stage III/IV were independent risk factors for progression-free survival(PFS).The comparison results of the survival curves showed that the overall survival(OS)of the patients in the SADTC group was significantly worse (P<0.01), while there was no significant difference in the PFS of different pathological types (χ2=5.024, P=0.081).The OS of different treatment methods was significantly different (P=0.002), but there was no significant difference in OS between local recurrence and distant metastases with or without surgery (χ2=0.954, P=0.329).
Conclusions: The STC has relatively unique clinical characteristics, and most patients can get a better prognosis after radical surgery. Pathological type, lateral cervical lymph node metastasis, tumor stage and treatment are important factors which affect the prognosis of the disease. Since there are two distinct tumors with different aggressiveness, treatment options and prognosis, individualized management is required.
Next-generation network transmission control protocol based on deep learning
Authors: M Nisha Angeline , Shivaranjani M , Manikandan S K , Gokul C
Published: September 2022

Long-term networks suffer from higher performance degradation and larger delays, making 5G wireless communications networks the best option for broadcasting and dealing with emergency situations. Obstructions and misalignment issues in the 5G millimetre wave spectrum can cause the link to be severed and the network to be severely impacted.. An intelligent Transport Control Protocol (iTCP) for a disaster 5G millimetre wave system is proposed in this study.iTCP learns about a node's movement and transmission power, and adjusts the congestion control window based on this information. In terms of network security and performance, iTCP outperforms TCP NewReno, Vegas, Westwood, Cubic, and Compound.
Neural activation patterns evoked by social inference in the laboratory predict the number of real-life social contacts
Authors: Tusche Anita , Spunt Robert , Paul Lynn , Tyszka Julian , Adolphs Ralph
Published: September 2022

We regularly infer other people’s thoughts and feelings from observing their actions, but it remains unknown how this ability contributes to successful social behavior and interactions. We show that neural activation patterns during social inferences obtained in the laboratory predict the number of social contacts in the real world in three community samples (total n=126) and a population with autism (n=23) (social network index, SNI). Cross-validated predictions were localized selectively to the right posterior superior temporal sulcus (pSTS) and were specific for social inferences, not nonsocial ones. Moreover, the multivariate pattern of brain activation during social inferences generalized across participants in the neurotypical and autism group (cross-sample prediction). Brain activations in pSTS also predicted autism-like trait scores (AQ, SRS-2) in neurotypical individuals and symptom severity scores (ADOS SA) in the autism group. These findings indicate that neural activations produced while thinking about other people’s mental states predict variance in other indices of social functioning - beyond the number of real-world social connections. Together, these findings point towards social inference as a latent variable that comes into play relatively ubiquitously in real-life social behavior. The results also demonstrate the potential of using localized, process-specific neurobiomarkers of cognitive abilities that contribute to social behavior as robust predictors of people’s social functioning in the real world.
Predicting pathological highly invasive lung cancer from preoperative 18F-FDG PET/CT with multiple machine learning models
Authors: Onozato Yuki , Iwata Takekazu , Uematsu Yasufumi , Shimizu Daiki , Yamamoto Takayoshi , Matsui Yukiko , Ogawa Kazuyuki , Kuyama Junpei , Sakairi Yuichi , Kawakami Eiryo , Iizasa Toshihiko , Yoshino Ichiro
Published: September 2022

Purpose: The efficacy of sublobar resection of primary lung cancer have been proven in recent years. However, sublobar resection for highly invasive lung cancer increases local recurrence. We developed and validated multiple machine learning models predicting pathological invasiveness of lung cancer based on preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and computed tomography (CT) radiomic features.
Methods: Overall, 873 patients who underwent lobectomy or segmentectomy for primary lung cancer were enrolled. Radiomics features were extracted from preoperative PET/CT images with the PyRadiomics package. Seven machine learning models and an ensemble of all models (ENS) were evaluated after 100 iterations. In addition, the probability of highly invasive lung cancer was calculated in a nested cross-validation to assess the calibration plot and clinical usefulness, and to compare to consolidation tumour ratio (CTR) on CT images, one of the generally used diagnostic criteria.
Results: In the training set, when PET and CT features were combined, all models achieved an area under the curve (AUC) of ≥ 0.880. In the test set, ENS showed the highest mean AUC of 0.880 and smallest standard deviation of 0.0165, and when the cutoff was 0.5, accuracy of 0.804, F1 of 0.851, precision of 0.821, and recall of 0.885. In the nested cross-validation, the AUC of 0.882 (95% CI: 0.860-0.905) showed a high discriminative ability, and the calibration plot indicated consistency with a Brier score of 0.131. A decision curve analysis showed that the ENS was valid with a threshold probability ranging from 3% to 98%. Accuracy showed an improvement of more than 8% over the CTR.
Conclusion: The machine learning model based on preoperative 18F-FDG PET/CT images was able to predict pathological highly invasive lung cancer with high discriminative ability and stability. The calibration plot showed good consistency, suggesting its usefulness in quantitative risk assessment.
Utero-vaginal anastomosis in cases of cervical malformations; Long term follow- up and fertility challenges
Authors: Fouad Reham , Zayed Mohamed
Published: September 2022

Purpose: To study the long-term results of utero-vaginal anastomosis in cases of cervical malformations.
Methods: this is a retrospective cohort study. Nine patients presented with cryptomenorrhea due to cervical malformations (5 patients with cervical agenesis and vaginal aplasia, 2 patients with cervical agenesis and upper vaginal aplasia, and two patients with cervical dysgenesis in form of cervical obstruction). Five patients had utero-vaginal anastomosis (UVA) with McIndoe vaginoplasty. Four patients had UVA without vaginoplasty. Follow up was done by transabdominal and/or transvaginal ultrasound monthly for the first three months then every six months thereafter for a duration that ranged from 15 to 82 months.
The main outcome measures are achieving menstruation, dysmenorrhea, pelvic inflammatory disease (PID), needed interventions after primary surgery, infertility, and pregnancy rate.
Results: 9 (100%) patients achieved menstruation, one (12%) experienced severe dysmenorrhea, two (22%) had PID, seven (78%) needed dilatation of the anastomosis site, three (33%) needed reoperation, 9 (100%) had primary infertility, two (28.5%) achieved clinical pregnancy, and only one (14%) ended by live birth.
Conclusion: Conservative surgeries for cervical malformation is a promising choice for relieving the obstructive symptoms. Regular dilatation is recommended. Pregnancy is a remote hope that is hindered by many challenges.
Identification and Validation of RNA Methylation-Related Related Alternative Splicing Gene Signature for Low Grade Glioma to Predict Survival and Immune Landscapes
Authors: Ma Chenggong , Bao Yunong , Xu Jiazhe , Xiao Bo , Li Hui
Published: September 2022

Background
Lower-grade glioma (LGG) is a crucial pathological type of Glioma. The present study aimed to explore multiple RNA methylation regulator-related AS events and investigate their prognostic values in LGG.
Methods
The prognostic model for Low-Grade Glioma was established by using the LASSO regression analysis. To validate prognostic value, we performed Kaplan-Maier survival analysis, ROC curves and nomograms. The ESTIMATE algorithm, the CIBERSORT algorithm and the ssGSEA algorithm were utilized to explore the role of the immune microenvironment in LGG. Subsequently, we then used GO, KEGG and GSEA enrichment analysis to explore the functional roles of these genes. In addition, we employed the GDSC database to screen potential chemotherapeutic agents.
Results
Eight RNA methylation related AS events were involved in construct a survival and prognosis model, which had good ability of independent prediction for patients with LGG. Patients in the high-risk group had shorter life expectancy and higher mortality, while patients in the low-risk group had a better prognosis. We constructed a nomogram which showed an excellent predictive performance for individual OS. The risk score exhibited a close correlation with some immune cells and expression of immune checkpoints. Patients in high-risk group were characterized by immunosuppressive microenvironment and poor response to immunotherapy, and were sensitive to more chemotherapeutic drugs. Pathway and functional enrichment analyses further confirmed that significant differences existed in immune landscape between the two subgroups.
Conclusion
The prognostic RNA Methylation-related Alternative Splicing signature we constructed could constitute a promising prognostic biomarker, which could serve to optimize treatment regimens.
Cholesterol removal in goat milk cheese and its chemical, textural
and sensory evaluation during storage
Authors: bastola Krishna
Published: September 2022

The experiment was conducted in a 2 x 3 x 3 factorial arrangement by having
two types (control and cholesterol reduced) goat milk cheeses, which were assigned to
three different storage temperatures (-18, 4, and 22°C) and three different storage
periods (0, 2, and 4 months). The objectives of this study were to: (1) evaluate
cholesterol removal rate of the CR cheese, (2) determine nutrient composition of CC
and CR cheeses and (3) compare pH, lipolysis, textural and sensory characteristics of
the 2 types of cheeses stored at 3 different temperatures for 3 storage periods. Results
showed that mean contents (%) of moisture, fat, ash, protein, and carbohydrate of CC
cheeses were: 41.4, 26.9, 3.87, 28.2 and 3.87, and those of CR cheeses were: 41.1, 22.9,
4.84, 35.1, and 3.93, respectively. The fat content of CR cheese was significantly lower
than that of CC cheese, indicating that significant part of fat was lost during cream
separation of the original cheese milk. Mean cholesterol concentration (mg/100g
cheese) of control and cholesterol removed cheese were 115.062 and 81.97 respectively,
suggesting that the cholesterol removal rate was only 28.7 %, which is substantially
lower than previous reports on bovine milk cheese studies. With respect to pH changes
in CC and CR cheeses during the 4 month storage at -18, 4 and 22 °C temperatures, CC
cheese had lower pH than CR cheese. There were no significant differences in pH
values for the different temperatures. However, the 2-way interaction effect of cheese
type x storage period showed significant (P<0.01) differences in pHs, Concerning
textural characteristics of the experimental cheeses, the textural parameters of CC
cheese had higher mean values than those of CR cheese for fresh samples. The ADV
values of control cheeses were higher than that of CR cheese samples. The 3-way
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interaction effect of cheese type x temperature x storage period showed highly
significant effect on acid degree value in both CC and CR cheeses. The 2-way
interaction of storage time x batch effect was also significant (P<0.01 and P<001) for
ADV values.The results of sensory evaluation on the CC and CR goat Cheddar cheeses
revealed that cooked flavor was not affected by main factors nor by their interactions.
However, storage period made greater influence on sweetness, freshness, high acid,
coarse, crumbly, sandy and color of the experimental cheese samples. On the other hand,
storage temperature had no impact on any of the sensory properties.
Development of a test strip for rapid detection of Gymnodinium catenatum
Authors: Fang Junhua , Li Shuyue , Liu Xiaoxiao , He Weixin , Li Lingyue , Zhang Jiazhao , Zhang Changgong , Zhou Kefu
Published: September 2022

Harmful algal blooms (HABs) are major ecological and environmental problems in China's coastal waters and seriously threaten the stability of the marine ecosystem and human health. Gymnodinium catenatum is a toxic red tide dinoflagellate. It can produce paralytic shellfish toxins (PSP), which cause serious hazards to marine organisms, public health and safety. In this paper, a test strip based on colloidal gold immunochromatography (GICG) was developed for the rapid detection of Gymnodinium catenatum. The experimental results showed that the test trip has good specificity and sensitivity. It not only detects the different components of Gymnodinium catenatum but also may detect algal toxins. The lowest density of Gymnodinium catenatum that can be detected by this test strip is approximately 120 cells/mL. Cross-reaction indicated that the test strip had a high specificity for Gymnodinium catenatum. This test strip provides a rapid method for on-site detection of Gymnodinium catenatum and a reference method for the monitoring of other harmful algae to serve as an early warning of upcoming red tides. It also provides a new way to prepare more detection methods for toxic algal toxins.
Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation
Authors: Yoshinari Miku , Nishibata Yuka , Masuda Sakiko , Nakazawa Daigo , Tomaru Utano , Arimura Yoshihiro , Amano Koichi , Yuzawa Yukio , Sada Ken-Ei , Atsumi Tatsuya , Dobashi Hiroaki , Hasegawa Hitoshi , Harigai Masayoshi , Takasaki Yoshinari , Saito Masaya , Matsuo Seiichi , Makino Hirofumi , Ishizu Akihiro
Published: September 2022

Background
Neutrophil extracellular traps (NETs) are critically involved in microscopic polyangiitis (MPA) pathogenesis, and some patients with MPA possess anti-NET antibody (ANETA). Anti-myosin light chain 6 (MYL6) antibody is an ANETA that affects NETs. This study aimed to determine the significance of anti-MYL6 antibody in MPA.
Methods
The influence of anti-MYL6 antibody on NET formation and actin rearrangement necessary for NET formation was assessed by fluorescent staining. An enzyme-linked immunosorbent assay was established to detect serum anti-MYL6 antibody, and the prevalence of this antibody in MPA was determined. Furthermore, the disease activity and response to remission-induction therapy of MPA were compared between anti-MYL6 antibody-positive and -negative MPA patients.
Results
Anti-MYL6 antibody disrupted G-actin polymerization into F-actin, suppressing phorbol 12-myristate 13-acetate-induced NET formation. Serum anti-MYL6 antibody was detected in 7 of 59 patients with MPA. The Birmingham vasculitis activity score (BVAS) of anti-MYL6 antibody-positive MPA patients was significantly lower than anti-MYL6 antibody-negative MPA patients. Among the nine BVAS evaluation items, the cutaneous, cardiovascular, and nervous system scores of anti-MYL6 antibody-positive MPA patients were significantly lower than anti-MYL6 antibody-negative MPA patients, although other items, including renal and chest scores, were equivalent between the two groups. The proportion of patients with remission 6 months after initiation of remission-induction therapy in anti-MYL6 antibody-positive MPA patients was significantly higher than in anti-MYL6 antibody-negative MPA patients.
Conclusions
Collective findings suggested that anti-MYL6 antibody disrupted actin rearrangement necessary for NET formation and could reduce the disease activity of MPA.
EnTube: A Dataset for YouTube Video Engagement Analytics
Authors: Le Truong , Nguyen-Thi Minh-Vuong , Le Huy , Vo Quoc-Thang , Le Tung , Nguyen Huy Tien
Published: September 2022

YouTube, one of the largest online video-sharing platforms today, has provided a place for content creators to share information and earn extra income. Anticipating whether a video will be engaged by viewers or not is an essential factor in helping video creators improve video content and quality before publishing. To facilitate this task, we build an annotated dataset of 23,738 videos collected from 72 YouTube channels in Vietnam that were in four categories (i.e., comedy, travel-and-events, education, science-and-technology) and published over 12 years. We evaluate a number of metrics for measuring video engagement to propose a novel measure which determines the engagement of a video via Q score. Using our proposed measure, we annotate videos with three levels of engagement including Engage, Neutral, and not Engage. From the supervised dataset, we constructed a multimodal model to infer the degree of engagement based on the content of a YouTube video such as title, audio, thumbnails, video, and tags. We believe our dataset and metric to be useful for engagement analytics as well as studies on social media content.
Early fluid-free macula and stability assessment: real world experience with Brolucizumab
Authors: Vadalà Maria , Grassi Maria Oliva , Alaimo Francesco , Moavero Chiara , Viggiano Pasquale , Boscia Francesco , Cillino Salvatore , Bonfiglio Vincenza Maria Elena
Published: September 2022

Purpose: Brolucizumab is the most recent anti-vascular endothelial growth factor (anti-VEGF) agent commercialized, approved for neovascular age-related macular degeneration (nAMD) as the first indication. A fluid-free retina and no recurrence of fluids are the new targets of retinal therapy, and early clinical experience with Brolucizumab shows strong effectiveness in drying retinal fluid. This study presents the results of real-world experience in treating nAMD naïve patients with intravitreal Brolucizumab.
Methods: This prospective observational study included 28 treatment-naïve eyes from two centres who underwent therapy with intravitreal injection of Brolucizumab for age-related neovascular macular degeneration. Several parameters were evaluated, including central retinal thickness (CRT), central retinal volume (CRV), intraretinal fluid (IRF), subretinal fluid (SRF), detachment of pigment retinal epithelium (PED), and subretinal hyper-reflective material (HRSM), from baseline up to 16 weeks.
Results: CTR and CRV reduced in a significant manner at w16 (p<0.0001 and p=0.01 respectively). SRF, IRF, PED, and HRSM almost disappeared in most cases. At w16, resolution of clinical activity was assessed at 86% to 89%, with PED showing a slower response. Interestingly, the cohort showed resolution of signs at w4 up to 82% of the eyes, after only one IVT-B. Visual acuity improved from 0.76 at baseline to 0.55 logMAR at w16 (p=0.002).
Conclusion: Our report strongly associated the effectiveness of the three-monthly induction treatment with a quick resolution of fluids in nAMD patients treated with Brolucizumab.
GADD34 activates p53 and may have utility as a marker of atherosclerosis
Authors: Tomiyoshi Go , Nakamura Rika , Shinmen Natsuko , Yoshida Yoichi , Mine Seiichiro , Machida Toshio , Kitamura Kenichiro , Iwase Katsuro , Iwadate Yasuo , Hiwasa Takaki , Kuroda Hideyuki
Published: September 2022

We previously identified growth arrest and DNA-damage-inducible gene 34 (GADD34) as a marker of ischemic stroke. In the present study, serum levels of anti-GADD34 antibodies were found to be significantly higher in patients with acute ischemic stroke or chronic kidney disease compared to healthy donors. We then examined the biological function of GADD34 by transfection into human osteosarcoma U2OS cells. Knockdown of GADD34 by siRNA resulted in enhanced cell proliferation, which was suppressed by knockdown of MDM2. Luciferase reporter assays revealed that the transactivation ability of p53 enhanced by genotoxic anticancer drugs such as camptothecin and etoposide was further potentiated by the presence of GADD34 and attenuated by co-transfection with p53 shRNA expression plasmids. Western blotting demonstrated increased p53 protein levels after treatment with camptothecin, which was also potentiated by GADD34 but suppressed by GADD34 siRNA, ATM siRNA, and wortmannin, an ATM inhibitor. GADD34 levels increased in response to treatment with camptothecin or adriamycin, and this increase was attenuated by MDM2 siRNA. Immunoprecipitation with anti-GADD34 antibodies followed by Western blotting with anti-MDM2 antibodies indicated ubiquitination of GADD34 is mediated by MDM2. Accordingly, GADD34 may function as a ubiquitination decoy to reduce p53 ubiquitination and increase p53 protein levels. Increased neuronal death due to activation of p53 by GADD34 may account for the elevated serum levels of anti-GADD34 antibodies observed in patients with acute ischemic stroke.
Investigation of the Effect of Impact Test Temperatures on the Compression After Impact Behavior of Composite Plates
Authors: BELEVİ Melih , NEJABATI Aıdın , KARASU Haşim Fırat
Published: September 2022

Bu çalışmanın amacı darbe testi sıcaklığının ve levha malzemesinin, kompozit levhaların darbe sonrası bası dayanımına etkisini tespit etmektir. Testler için her biri 3 tabakalı olan biaxial cam elyaf/epoksi, karbon elyaf/epoksi ve kevlar elyaf/epoksi plakalar hazırlanmıştır. Farklı sıcaklıklarda (-20 ⁰C, 20 ⁰C ve 60 ⁰C’de) 50 J’lük darbe uygulanmış olan numunelere sıkıştırma (Darbe sonrası bası “CAI”) testleri yapılmıştır. Testler INSTRON 1114 test makinesinde, ASTM D7137 standardına göre hazırlanan Boeing test aparatı ve yük hücresi kullanılarak uygulanmıştır. Numunelerin kalınlık ve genişliğine göre küçük ayarlamalar yapılabilen aparat ile numuneler üzerine bası uygulanarak hasar üzerindeki etkisi incelenmiştir. Yük hücresinden elde edilen bilgileri kullanarak her numune için kuvvet-deplasman eğrisi oluşturulmuş ve numunelerin taşıyabileceği maksimum kuvvet elde edilmiştir. Hasar mekanizmasının anlaşılması için hasar gözlemi yapılmıştır. Test sonuçları, sıcaklık değişimlerinin bütün numunelerde darbe sonrası bası davranışını etkilediğini göstermektedir. Levha malzemesinin de hasarın büyüklüğünde etkili olduğu görülmüştür.