bluuebunny/crossref_metadata_2025 huggingface dataset:
Brain oscillation recordings of the audience in a live concert-like setting
Authors: Tervaniemi Mari , Pousi Saara , Seppälä Maaria , Makkonen Tommi
Published: December 2021

There are only a few previous EEG studies that were conducted while the audience is listening to live music. However, in laboratory settings using music recordings, EEG frequency bands theta and alpha are connected to music improvisation and creativity. Here, we measured EEG of the audience in a concert-like setting outside the laboratory and compared the theta and alpha power evoked by partly improvised versus regularly performed familiar versus unfamiliar live classical music. To this end, partly improvised and regular versions of pieces by Bach (familiar) and Melartin (unfamiliar) were performed live by a chamber trio. EEG data from left and right frontal and central regions of interest were analysed to define theta and alpha power during each performance. After the performances, the participants rated how improvised and attractive each of the performances were. They also gave their affective ratings before and after each performance. We found that theta power was enhanced during the familiar improvised Bach piece and the unfamiliar improvised Melartin piece when compared with the performance of the same piece performed in a regular manner. Alpha power was not modulated by manner of performance or by familiarity of the piece. Listeners rated partly improvised performances of a familiar Bach and unfamiliar Melartin piece as more improvisatory and innovative than the regular performances. They also indicated more joy and less sadness after listening to the unfamiliar improvised piece of Melartin and less fearful and more enthusiastic after listening to the regular version of Melartin than before listening. Thus, according to our results, it is possible to study listeners’ brain functions with EEG during live music performances outside the laboratory, with theta activity reflecting the presence of improvisation in the performances.
Tissue Engineering of Canine Cartilage from Surgically Debrided Osteochondritis Dissecans Fragments
Authors: Vapniarsky Natalia , Moncada Lilia , Garrity Carissa , Wong Alice , Filliquist Barbro , Chou Po-Yen , Kapatkin Amy S. , Marcellin-Little Denis J.
Published: December 2021

This study in dogs explored the feasibility of using cartilage fragments removed and discarded during routine palliative surgery for osteochondritis dissecans (OCD) as a source of primary chondrocytes for scaffold-free cartilage tissue-engineering. Primary chondrocytes were obtained from three OCD donors and one age-matched healthy articular cartilage (HAC) donor. After monolayer expansion of primary cells, a three-dimensional spherical suspension culture was implemented. Following this stage, cells were seeded at a high density into custom-made agarose molds that allowed for size and shape-specific constructs to be generated via a method of cellular self-assembling in a scaffold-free environment. Fifty-eight neocartilage constructs were tissue-engineered using this methodology. Neocartilage constructs and native cartilage from shoulder joint were subjected to histological, mechanical, and biochemical testing. OCD and HAC chondrocytes-sourced constructs had uniformly flat morphology and histology consistent with cartilage tissue. Constructs sourced from OCD chondrocytes were 1.5-times (32%) stiffer in compression and 1.3 times (23%) stronger in tension than constructs sourced from HAC chondrocytes and only 8.7-times (81%) less stiff in tension than native tissue. Constructs from both cell sources consistently had lower collagen content than native tissue (22.9%/dry weight [DW] for OCD and 4.1%/DW for HAC vs. 51.1%/DW native tissue). To improve the collagen content and mechanical properties of neocartilage, biological and mechanical stimuli, and thyroid hormone (tri-iodothyronine) were applied to the chondrocytes during the self-assembling stage in two separate studies. A 2.6-fold (62%) increase in compressive stiffness was detected with supplementation of biological stimuli alone and 5-fold (81%) increase with combined biological and mechanical stimuli at 20% strain. Application of thyroid hormone improved collagen content (1.7-times, 33%), tensile strength (1.8-times, 43%), and stiffness (1.3-times, 21%) of constructs, relative to untreated controls. Collectively, these data suggest that OCD chondrocytes can serve as a reliable cell source for cartilage tissue-engineering and that canine chondrocytes respond favorably to biological and mechanical stimuli that have been shown effective in chondrocytes from other animal species, including humans.
Progression and metastasis of small cell lung carcinoma: the role of the PI3K/Akt/mTOR pathway and metabolic alterations
Authors: Krencz Ildiko , Sztankovics Daniel , Danko Titanilla , Sebestyen Anna , Khoor Andras
Published: December 2021

Small cell lung carcinoma (SCLC) is characterized by high metastatic rate and poor prognosis. The platinum-based chemotherapy still represents the backbone of the therapy; however, acquired resistance develops almost in all patients. Although SCLC has been formerly considered a homogeneous disease, recent advances in SCLC research have highlighted the importance of inter- and intratumoral heterogeneity and have resulted in the subclassification of SCLC. The newly described SCLC subtypes are characterized by distinct biological behavior and vulnerabilities that can be therapeutically exploited. The PI3K/Akt/mTOR pathway is frequently affected in SCLC, and its activation represents a promising therapeutic target. Since the mTOR pathway is a master regulator of cellular metabolism, its alterations may also influence the bioenergetic processes of SCLC cells. Despite the encouraging preclinical results, both mTOR and metabolic inhibitors have met limited clinical success so far. Patient selection for personalized therapy, the development of rational drug combinations, and a better understanding of heterogeneity and spatiotemporal evolution of the tumor cells may improve efficacy and can help to overcome acquired resistance. Here we provide a summary of current investigations regarding the role of the mTOR pathway and metabolic alterations in the progression and metastasis formation of SCLC.
A 24-Year Record of Female Reproductive Dynamics in Two Sympatric Mouse Lemur Species in Northwestern Madagascar
Authors: Radespiel Ute , Rakotondravony Romule , Rasoloharijaona Solofonirina , Randrianambinina Blanchard
Published: December 2021

Seasonal reproduction is widespread among primates but the degree of reproductive synchrony and plasticity can vary, even between closely related species. This study compares the dynamics of female reproductive seasonality in two mouse lemur species, Microcebus murinus and M. ravelobensis, in Ankarafantsika National Park, Madagascar, across 24 years. We collected 4321 records of female reproductive state from 1033 individual females (319 M. murinus, 714 M. ravelobensis). The analyses revealed disparate reproductive schedules: While female M. murinus showed high degrees of reproductive synchrony throughout all years, leading to the production of two successive litters, the seasonal onset of estrus (= reproductive activation) in female M. ravelobensis was more flexible than in M. murinus, starting 2-4 weeks earlier, varying by up to 4 weeks between years, and being less synchronized. M. ravelobensis females became reproductively active later in years with more rainfall, in particular rain in February, but the timing of reproductive activation was not related to differences in temperatures. The likelihood of early conception was significantly lower in M. ravelobensis than in M. murinus. This was partly due to delayed reproductive activation in young animals, and a lower likelihood of early conception for females with low body mass in M. ravelobensis. Our results suggest high, adaptive reproductive plasticity in M. ravelobensis that may enable individuals to respond flexibly to yearly environmental changes and expand the reproductive period under favorable conditions. These species differences in reproductive schedules may be the result of the divergent evolutionary histories of the two mouse lemur species in different parts of Madagascar.
Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity
Authors: Hesse Julia , Rosse Mona K. , Steckel Bodo , Blank-Landeshammer Bernhard , Idel Svenja , Reinders Yvonne , Sickmann Albert , Sträter Norbert , Schrader Jürgen
Published: December 2021

CD73-derived adenosine plays a major role in damage-induced tissue responses by inhibiting inflammation. Damage-associated stimuli, such as hypoxia and mechanical stress, induce the cellular release of ATP and NAD+ and upregulate the expression of the nucleotide-degrading purinergic ectoenzyme cascade, including adenosine-generating CD73. Extracellular NAD+ also serves as substrate for mono-ADP-ribosylation of cell surface proteins, which in human cells is mediated by ecto-ADP-ribosyltransferase 1 (ARTC1). Here we explored, whether human CD73 enzymatic activity is regulated by mono-ADP-ribosylation, using recombinant human CD73 in the presence of ARTC1 with etheno-labelled NAD+ as substrate. Multi-colour immunoblotting with an anti-etheno-adenosine antibody showed ARTC1-mediated transfer of ADP-ribose together with the etheno label to CD73. HPLC analysis of the enzymatic activity of in vitro-ribosylated CD73 revealed strong inhibition of adenosine generation in comparison to non-ribosylated CD73. Mass spectrometry of in vitro-ribosylated CD73 identified six ribosylation sites. 3D model analysis indicated that three of them (R328, R354, R545) can interfere with CD73 enzymatic activity. Our study identifies human CD73 as target for ARTC1-mediated mono-ADP-ribosylation, which can profoundly modulate its adenosine-generating activity. Thus, in settings with enhanced release of NAD+ as substrate for ARTC1, assessment of CD73 protein expression in human tissues may not be predictive of adenosine formation resulting in anti-inflammatory activity.
Quantum-safe cryptography: crossroads of coding theory and cryptography
Authors: Wang Jiabo , Liu Ling , Lyu Shanxiang , Wang Zheng , Zheng Mengfan , Lin Fuchun , Chen Zhao , Yin Liuguo , Wu Xiaofu , Ling Cong
Published: December 2021

We present an overview of quantum-safe cryptography (QSC) with a focus on post-quantum cryptography (PQC) and information-theoretic security. From a cryptographic point of view, lattice and code-based schemes are among the most promising PQC solutions. Both approaches are based on the hardness of decoding problems of linear codes with different metrics. From an information-theoretic point of view, lattices and linear codes can be constructed to achieve certain secrecy quantities for wiretap channels as is intrinsically classical- and quantum-safe. Historically, coding theory and cryptography are intimately connected since Shannon’s pioneering studies but have somehow diverged later. QSC offers an opportunity to rebuild the synergy of the two areas, hopefully leading to further development beyond the NIST PQC standardization process. In this paper, we provide a survey of lattice and code designs that are believed to be quantum-safe in the area of cryptography or coding theory. The interplay and similarities between the two areas are discussed. We also conclude our understandings and prospects of future research after NIST PQC standardisation.
Cross-scale trade-off analysis for sustainable development: linking future demand for animal source foods and ecosystem services provision to the SDGs
Authors: Kozicka Marta , Jones Sarah K. , Gotor Elisabetta , Enahoro Dolapo
Published: December 2021

Dietary transition towards higher consumption of animal source foods (ASF) associated with higher incomes across low and middle-income countries could have negative impacts on environmental systems and their potential in the long run to provide services necessary for achieving multiple Sustainable Development Goals (SDGs). In this article, we integrate economic, land use allocation, and biophysical models to investigate trade-offs between the five ecosystem services and their contributions to various SDGs associated with agricultural expansion to meet future demand for ASF, using Tanzania as a case study. Our results show that under the scenario of sustainable socio-economic development, between 2010 and 2030 in Tanzania, per capita income grows by 169% and the share of population at risk of hunger declines from 34.8% to 23%. These changes can be associated on a macro-level with positive contributions to achievement of SDG 1 (No Poverty) and SDG 2 (Zero Hunger). To satisfy feed demand for increased livestock production domestically, an increase by 21.4% of biomass production as compared to 2010 is needed. Analysis of alternative scenarios for meeting this new demand shows potential threats on a landscape level to achieving numerous SDGs and more generally to attaining sustainable food systems. Ecosystem-based contributions primarily decline to SDGs: SDG 3 (Health), SDG 6 (Clean Water), SDG 11 (Sustainable Cities), SDG 13 (Climate) and SDG 15 (Terrestrial Life). We find that higher crop productivity and redesign of agro-ecosystems to increase on-farm tree cover could significantly limit these losses. Alternatively, the growing demand for ASF could be satisfied with imports, which would allow for reducing the trade-offs locally. However, this would result in at least partially only displacing ecosystem service losses to the exporting countries.
The β-Secretase Substrate Seizure 6–Like Protein (SEZ6L) Controls Motor Functions in Mice
Authors: Ong-Pålsson Emma , Njavro Jasenka Rudan , Wilson Yvette , Pigoni Martina , Schmidt Andree , Müller Stephan A. , Meyer Michael , Hartmann Jana , Busche Marc Aurel , Gunnersen Jenny M. , Munro Kathryn M. , Lichtenthaler Stefan F.
Published: December 2021

The membrane protein seizure 6–like (SEZ6L) is a neuronal substrate of the Alzheimer’s disease protease BACE1, and little is known about its physiological function in the nervous system. Here, we show that SEZ6L constitutive knockout mice display motor phenotypes in adulthood, including changes in gait and decreased motor coordination. Additionally, SEZ6L knockout mice displayed increased anxiety-like behaviour, although spatial learning and memory in the Morris water maze were normal. Analysis of the gross anatomy and proteome of the adult SEZ6L knockout cerebellum did not reveal any major differences compared to wild type, indicating that lack of SEZ6L in other regions of the nervous system may contribute to the phenotypes observed. In summary, our study establishes physiological functions for SEZ6L in regulating motor coordination and curbing anxiety-related behaviour, indicating that aberrant SEZ6L function in the human nervous system may contribute to movement disorders and neuropsychiatric diseases.
High Carbon Amendments Increase Nitrogen Retention in Soil After Slurry Application—an Incubation Study with Silty Loam Soil
Authors: Cao Xinyue , Reichel Rüdiger , Wissel Holger , Kummer Sirgit , Brüggemann Nicolas
Published: December 2021

Excess nitrogen (N) after animal slurry application is a persistent problem of intensive agriculture, with consequences such as environmental pollution by ammonia (NH3) and nitrous oxide (N2O) emissions and nitrate (NO3−) leaching. High-carbon organic soil amendments (HCAs) with a large C:N ratio have shown the potential of mitigating unintended N losses from soil. To reduce gaseous and leaching N losses after the application of slurry, a laboratory incubation study was conducted with silt loam soil. We tested the potential of three different types of HCA—wheat straw, sawdust, and leonardite (application rate 50 g C L−1 slurry for each of the three HCAs)—to mitigate N loss after amendment of soil with pig and cattle slurry using two common application modes (slurry and HCA mixed overnight with subsequent addition to soil vs. sequential addition) at an application rate equivalent to 80 kg N ha−1. Compared to the control with only soil and slurry, the addition of leonardite reduced the NH3 emissions of both slurries by 32–64%. Leonardite also reduced the total N2O emissions by 33–58%. Wheat straw reduced N2O emissions by 40–46%, but had no effect on NH3 emission. 15 N labeling showed that the application of leonardite was associated with the highest N retention in soil (24% average slurry N recovery), followed by wheat straw (20% average slurry N recovery). The mitigation of N loss was also observed for sawdust, although the effect was less consistent compared with leonardite and wheat straw. Mixing the slurry and HCA overnight tended to reduce N losses, although the effect was not consistent across all treatments. In conclusion, leonardite improved soil N retention more effectively than wheat straw and sawdust.
Developing connections for engagement in stroke rehabilitation
Authors: Kayes Nicola M. , Cummins Christine , McPherson Kathryn M. , Worrall Linda , Bright Felicity A. S.
Published: December 2021

Background and Aims:

Engagement is increasingly recognised as important for maximising rehabilitation outcome following stroke. However, engagement can be challenging when neurological impairment impacts a persons’ ability to activate the regulatory processes necessary for engagement and in the context of a changed self. We explored engagement in stroke rehabilitation from the perspective of people with stroke with a primary focus on identifying key processes that appeared important to engagement in stroke rehabilitation.

Design and Methods:

This study drew on Interpretive Description methodology. Maximum variation and theoretical sampling were used to capture diversity in the sample and access a depth and breadth of perspectives. Data collection included semi-structured interviews with people with stroke (n = 19). Data were analysed through a collaborative and iterative process drawing on range of analytical tools including coding, memoing, diagramming and group discussions.

Findings:

Our findings highlight that engagement is a complex, nuanced, responsive, flexible and inherently two-way process.Developing connectionsappeared central to engagement with connections taking various forms. The most fundamental was the therapeutic connection between the person with stroke and their practitioner as it provided the foundation on which to build other connections. Connection was made possible through five collaborative processes:Knowing, Entrusting, Adapting, Investing and Reciprocating.

Conclusions:

Engagement is a social and relational process enabled through an inherently person-centred approach and active and ongoing reflexivity – highlighting the importance of a humanising approach to care where aspects of self, care and emotion are evident, for both the person with stroke and their practitioner.
Vicarious Trauma: Exploring the Experiences of Qualitative Researchers Who Study Traumatized Populations
Authors: Smith Erin , Pooley Julie-Ann , Holmes Lisa , Gebbie Kristine , Gershon Robyn
Published: December 2021

Objective:

A substantial body of research exists regarding vicarious trauma (VT) exposure among helping professionals across disciplines and settings. There is limited research, however, on exposure to VT in qualitative researchers studying traumatized populations. The objective of this study was to explore the experiences of qualitative researchers who study traumatized populations and to identify potential protective strategies for reducing the risk of VT.

Methods:

The study utilized a qualitative methodological design. Focus groups and in-depth interviews were conducted using a semi-structured script. Thematic analysis was conducted to identify both risk factors and protective factors associated with VT. A sample of 58 research participants were recruited using a multimodal recruitment strategy.

Results:

Using thematic analysis, the following key themes emerged: exposure to primary trauma, the impact of stigma, organizational context, individual context, and research context. The opportunity for posttraumatic growth was also identified.

Conclusion:

Qualitative researchers of traumatized populations need to recognize the potential for VT and implement appropriate protection strategies from the risk of VT. The development of policies and guidelines that recognize the importance of both self-care and plan for researcher safety and well-being is a potential strategy for building researcher resilience and preventing VT.
Personal or Impersonal Evaluations? Political Sophistication and Citizen Conceptions of the Democratic Process
Authors: Rapeli Lauri , von Schoultz Åsa
Published: December 2021

An energetic scholarly debate discusses possible reforms of representative democracy. Some support participatory forms of democracy, others a more elite-driven or technocratic democracy. This study contributes to the growing literature on the subject by emphasizing political sophistication as a theoretically relevant predictor of attitudes to democracy: different models of democracy make different demands regarding the political sophistication of citizens. The analysis includes two dimensions and three measures of sophistication: personal sophistication measured as political knowledge and internal efficacy, and impersonal sophistication measured as assessment of others’ political competence. Using the 2011 Finnish National Election Study, we find that perceptions of the sophistication of others have a substantial impact on preferences for political decision-making, and that politically sophisticated people support representative democracy. The analysis shows that perceptions of others’ political competence, which has been largely neglected by previous research, is a both theoretically and empirically relevant predictor of preferences for political decision-making processes.
Twelve Votes for an Exit: Compromise and Responsiveness in the Brexit Process
Authors: Giuliani Marco
Published: December 2021

Brexit has been at the centre of the last two British elections and the past legislative term. The UK's exit from the European Union was characterized by a series of parliamentary setbacks, with several government defeats, continuous rebellions and cross-party agreements made to secure control of the agenda. In the research reported in this article, we analyse the parliamentary Brexit process through careful examination of the 12 indicative votes held in Westminster in 2019 to find an alternative solution to Theresa May's exit agreement. We map the choices of each MP along two relevant dimensions, connecting them to the socioeconomic structure of their constituencies as well as to the preferences expressed in the 2016 Brexit referendum. Moreover, we associate these parliamentary behaviours – and thus MPs' attitudes towards compromise and responsiveness – to the gains and losses experienced during the subsequent 2019 general election.
Coronavirus disease 2019 (COVID-19) vaccine intentions and uptake in a tertiary-care healthcare system: A longitudinal study
Authors: Evans Charlesnika T. , DeYoung Benjamin J. , Gray Elizabeth L. , Wallia Amisha , Ho Joyce , Carnethon Mercedes , Zembower Teresa R. , Hirschhorn Lisa R. , Wilkins John T.
Published: December 2021

Objectives:

Healthcare workers (HCWs) are a high-priority group for coronavirus disease 2019 (COVID-19) vaccination and serve as sources for public information. In this analysis, we assessed vaccine intentions, factors associated with intentions, and change in uptake over time in HCWs.

Methods:

A prospective cohort study of COVID-19 seroprevalence was conducted with HCWs in a large healthcare system in the Chicago area. Participants completed surveys from November 25, 2020, to January 9, 2021, and from April 24 to July 12, 2021, on COVID-19 exposures, diagnosis and symptoms, demographics, and vaccination status.

Results:

Of 4,180 HCWs who responded to a survey, 77.1% indicated that they intended to get the vaccine. In this group, 23.2% had already received at least 1 dose of the vaccine, 17.4% were unsure, and 5.5% reported that they would not get the vaccine. Factors associated with intention or vaccination were being exposed to clinical procedures (vs no procedures: adjusted odds ratio [AOR], 1.39; 95% confidence interval [CI], 1.16–1.65) and having a negative serology test for COVID-19 (vs no test: AOR, 1.46; 95% CI, 1.24–1.73). Nurses (vs physicians: AOR, 0.24; 95% CI, 0.17–0.33), non-Hispanic Black (vs Asians: AOR, 0.35; 95% CI, 0.21–0.59), and women (vs men: AOR, 0.38; 95% CI, 0.30–0.50) had lower odds of intention to get vaccinated. By 6-months follow-up, >90% of those who had previously been unsure were vaccinated, whereas 59.7% of those who previously reported no intention of getting vaccinated, were vaccinated.

Conclusions:

COVID-19 vaccination in HCWs was high, but variability in vaccination intention exists. Targeted messaging coupled with vaccine mandates can support uptake.
Spatial and temporal effects on severe acute respiratory coronavirus virus 2 (SARS-CoV-2) contamination of the healthcare environment
Authors: Ziegler Matthew J. , Huang Elizabeth , Bekele Selamawit , Reesey Emily , Tolomeo Pam , Loughrey Sean , David Michael Z. , Lautenbach Ebbing , Kelly Brendan J. ,   for the CDC Prevention Epicenters Program
Published: December 2021

Background:

The spatial and temporal extent of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) environmental contamination has not been precisely defined. We sought to elucidate contamination of different surface types and how contamination changes over time.

Methods:

We sampled surfaces longitudinally within COVID-19 patient rooms, performed quantitative RT-PCR for the detection of SARS-CoV-2 RNA, and modeled distance, time, and severity of illness on the probability of detecting SARS-CoV-2 using a mixed-effects binomial model.

Results:

The probability of detecting SARS-CoV-2 RNA in a patient room did not vary with distance. However, we found that surface type predicted probability of detection, with floors and high-touch surfaces having the highest probability of detection: floors (odds ratio [OR], 67.8; 95% credible interval [CrI], 36.3–131) and high-touch elevated surfaces (OR, 7.39; 95% CrI, 4.31–13.1). Increased surface contamination was observed in room where patients required high-flow oxygen, positive airway pressure, or mechanical ventilation (OR, 1.6; 95% CrI, 1.03–2.53). The probability of elevated surface contamination decayed with prolonged hospitalization, but the probability of floor detection increased with the duration of the local pandemic wave.

Conclusions:

Distance from a patient’s bed did not predict SARS-CoV-2 RNA deposition in patient rooms, but surface type, severity of illness, and time from local pandemic wave predicted surface deposition.
Pollinator-friendly flora in rangelands following control of cheatgrass (Bromus tectorum): a case study
Authors: H. S. Arathi , Hardin Janet
Published: December 2021

Invasive winter annual grasses, such as cheatgrass (Bromus tectorumL.) are considered serious threats to regional biodiversity. Pollinator populations that depend on the native flora are likely to be negatively impacted as these native species may be displaced by the invasive grass species. Colonization by cheatgrass is also predicted to increase risk of wildfires, as dead plant parts provide fuel in the already dry and arid regions of the western United States. Biocontrol, grazing, prescribed burning, or use of broad-spectrum nonselective herbicides have been suggested as possible means to controlB. tectorum. Efficient control may facilitate regrowth of native flora that could in turn support other ecosystem functions. Reporting our findings as a case study, we describe here the results of the application of a preemergent herbicide, indaziflam, that limits germination ofB. tectorumseeds. Herbicide was applied to the study locations during the months of December 2016, January 2017, and February 2017. The data reported here on the diversity of flowering plants were collected between May through September 2018. Herbicide-treated plots showed an increase in diversity and abundance of flowering plants compared to the untreated control within two seasons after cheatgrass control was implemented, suggesting that effective reduction of the population of the invasive annual cheatgrass may help facilitate the growth of native forbs. Further studies are necessary to understand mechanisms that facilitate reestablishment of native flowering species, the long-term consequences of reducing invasive annual grasses and to document any residual effects of the herbicide on ground-nesting pollinators.
The Wilmot Committee: Redefining Relief and National Interest in Britain during the French Revolution
Authors: Muller Hannah Weiss
Published: December 2021

Although anti-Catholicism and anti-Jacobinism primed many Britons to fear what one observer called “the hordes of vagabond French” who reached their shores in the fall of 1792, others launched widespread relief efforts. Among the more remarkable was the Wilmot Committee. This subscription charity convened in September 1792, channeling donations from the public to destitute French priests at a time when the British government remained hesitant to directly aid refugees from revolutionary France. This article situates the committee's particular structures in both their eighteenth-century philanthropic contexts and Britain's history of aid to foreign refugees. It then traces interconnections between charitable giving and wartime exigencies, arguing that the Wilmot Committee, which managed relief efforts first to clergy and then also to laity throughout the subsequent war years in an evolving partnership with government, played a crucial role in shaping and shifting attitudes toward foreigners during an era of ideological revolution. Ultimately, the committee worked alongside legislation like the Aliens and Emigrant Corps Acts to underline that foreigners of different religious persuasions—provided their loyalties were confirmed, their principles appropriate, and their backgrounds appealing—might be mobilized to strengthen national interests. By the 1790s, shared opposition to revolutionary republican ideology came to supersede shared Protestantism in predicting foreigners’ utility to Britain.
Seasonal ice dynamics in the lower ablation zone of Dagongba Glacier, southeastern Tibetan Plateau, from multitemporal UAV images
Authors: Fu Yin , Liu Qiao , Liu Guoxiang , Zhang Bo , Zhang Rui , Cai Jialun , Wang Xiaowen , Xiang Wei
Published: December 2021

Most glaciers on the Tibetan Plateau have experienced continuous mass losses in response to global warming. However, the seasonal dynamics of glaciers on the southeastern Tibetan Plateau have rarely been reported in terms of glacier surface elevation and velocity. This paper presents a first attempt to explore the seasonal dynamics of the debris-covered Dagongba Glacier within the southeastern Tibetan Plateau. We use the multitemporal unoccupied aerial vehicle images collected over the lower ablation zone on 8 June and 17 October 2018, and 13 May 2019, and then perform an analysis concerning climatic fluctuations. The results reveal that the mean surface elevation decrease of the Dagongba Glacier during the warm season ($2.81\pm 0.44$ m) was remarkably higher than the cold season ($0.72\pm 0.45$ m). Particularly notable glacier surface elevation changes were found around supraglacial lakes and ice cliffs where ice ablation rates were $\sim$3 times higher than the average. In addition, a larger longitudinal decline of glacier surface velocity was observed in the warm season than that in the cold season. In terms of further comparative analysis, the Dagongba Glacier experienced a decrease in surface velocity between 1982–83 and 2018–19, with a decrease in the warm season possibly twice as large as that in the cold season.
NEW AMS 14C DATES OF A MULTICULTURAL ARCHAEOLOGICAL SITE FROM THE PALEO-DELTAIC REGION OF WEST BENGAL, INDIA: CULTURAL AND GEO-ARCHAEOLOGICAL IMPLICATIONS
Authors: Naskar Nabanita , Gangopadhyay Kaushik , Lahiri Susanta , Chaudhuri Punarbasu , Sharma Rajveer , Kumar Pankaj , Ojha Sunil , Chopra Sundeep , Ghosh Ahana
Published: December 2021

This study is on the absolute age dating of a multicultural site of Erenda, East Medinipur district, in coastal West Bengal, India. Charcoal samples were collected and measured using the accelerator mass spectrometry (AMS) facility at the Inter-University Accelerator Centre, New Delhi, India. These samples were collected from secured stratigraphic context of two excavated trenches. A careful collection of samples from two trenches provided us with the first calendar dates, 950 BCE and 1979 BCE, of protohistoric sites in coastal West Bengal. These calibrated calendar dates not only have wider significance in terms of archaeology but also methodological implications to understand the relevance of application of AMS from the dynamic coastal landscape in the humid tropics during the late Holocene period.
Francisco Franco Is Back: The Contested Reemergence of a Fascist Moral Exemplar
Authors: Ferrándiz Francisco
Published: December 2021

Based on long-term ethnographic research on contemporary exhumations of mass graves from the Spanish Civil War (1936–1939), as well as analysis of the exhumation of Francisco Franco from the Valley of the Fallen, this paper looks at the ways in which the dictator’s moral exemplarity has evolved over time since his military victory in 1939. During the early years of his dictatorship, Franco’s propaganda machine built the legend of a historical character touched by divine providence who sacrificed himself to save Spain from communism. His moral charisma was enriched by associating his historical mission with a constellation of moral exemplars drawn from medieval and imperial Spain. After his death, his moral exemplarity dwindled as democratic Spain embraced a political discourse of national reconciliation. Yet, since 2000, a new negative exemplarity of Franco as a war criminal has come into sharp focus, in connection with the exhumation of the mass graves of tens of thousands of Republican civilians executed by his army and paramilitary. In recent years, Franco has reemerged as a fascist exemplar alongside a rise of the extreme right. To understand the revival of his fascist exemplarity, I focus on two processes: the rise of the political party Vox, which claims undisguised admiration for Franco’s legacy (a process I call “neo-exemplarity”), and the dismantling in October 2019 of Franco’s honorable burial and the debate over the treatment that his mortal remains deserve (a process I call “necro-exemplarity”).
TRANSCENDING THE INDIVIDUAL/COLLECTIVE MINORITY RIGHTS DIVIDE: A PROCEDURAL SOLUTION
Authors: Körtvélyesi Zsolt
Published: December 2021

Relying on examples from international, EU and comparative law and drawing on insights from the class action literature, this article argues that important advances in minority rights protection can be achieved without the revision of substantive legal provisions and the full-scale embracing of collective rights. Allowing minority members to present their claims on behalf of a larger group (collective procedure), even when such claims ultimately rest on the rights of individuals as opposed to those of the group, strengthens minority rights and can transform our vision of them. An overview of eight interrelated benefits shows not only how these advantages occur, but also why the procedural approach avoids the issues that motivate negative critiques of group rights.
ESTIMATES OF DERIVATIVES OF (LOG) DENSITIES AND RELATED OBJECTS
Authors: Pinkse Joris , Schurter Karl
Published: December 2021

We estimate the density and its derivatives using a local polynomial approximation to the logarithm of an unknown density function f. The estimator is guaranteed to be non-negative and achieves the same optimal rate of convergence in the interior as on the boundary of the support of f. The estimator is therefore well-suited to applications in which non-negative density estimates are required, such as in semiparametric maximum likelihood estimation. In addition, we show that our estimator compares favorably with other kernel-based methods, both in terms of asymptotic performance and computational ease. Simulation results confirm that our method can perform similarly or better in finite samples compared to these alternative methods when they are used with optimal inputs, that is, an Epanechnikov kernel and optimally chosen bandwidth sequence. We provide code in several languages.
Temperature and soils predict the distribution of plant species along the Himalayan elevational gradient
Authors: Maharjan Surya Kumar , Sterck Frank J. , Raes Niels , Poorter Lourens
Published: December 2021

Tropical montane systems are characterized by a high plant species diversity and complex environmental gradients. Climate warming may force species to track suitable climatic conditions and shift their distribution upward, which may be particularly problematic for species with narrow elevational ranges. To better understand the fate of montane plant species in the face of climate change, we evaluated a) which environmental factors best predict the distribution of 277 plant species along the Himalayan elevational gradient in Nepal, and b) whether species elevational ranges increase with increasing elevation. To this end, we developed ecological niche models using MaxEnt by combining species survey and presence data with 19 environmental predictors. Key environmental factors that best predicted the distribution of Himalayan plant species were mean annual temperature (for 54.5% of the species) followed by soil clay content (10.2%) and slope (9.4%). Although temperature is the best predictor, it is associated with many other covariates that may explain species distribution, such as irradiance and potential evapotranspiration. Species at both ends of the Himalayan elevational gradient had narrower elevational ranges than species in the middle. Our results suggest that with further global warming, most Himalayan plant species have to migrate upward, which is especially critical for upland species with narrow distribution ranges.
Local Policy Discretion in Social Welfare: Explaining Subnational Variations in China's De Facto Urban Poverty Line
Authors: Guo Yu , He Alex Jingwei , Wang Fei
Published: December 2021

How do subnational agents exercise policy discretion in the social welfare sphere? To what extent do they do so as a result of various bureaucratic and fiscal incentives? The literature has documented several explanatory frameworks in the context of China that predominantly focus on the realm of developmental policies. Owing to the salient characteristics of the social policy arena, local adaptation of centrally designed policies may operate on distinctive logics. This study synthesizes the recent scholarship on subnational social policymaking and explains the significant interregional disparities in China's de facto urban poverty line – the eligibility standard of the urban minimum livelihood guarantee scheme, or dibao. Five research hypotheses are formulated for empirical examination: fiscal power effect, population effect, fiscal dependency effect, province effect and neighbour effect. Quantitative analysis of provincial-level panel data largely endorses the hypotheses. The remarkable subnational variations in dibao standards are explained by a salient constellation of fiscal and political factors that are embedded within the country's complex intergovernmental relations and fiscal arrangements. Both a race-to-the-top and a race-to-the-bottom may be fostered by distinctive mechanisms. The unique role of provincial governments as intermediary agents within China's political apparatus is illuminated in the social policy arena.
A meta-analysis examining technology-assisted L2 vocabulary learning
Authors: Yu Aiqing , Trainin Guy
Published: December 2021

This meta-analysis examines the effectiveness of technology-assisted second language (L2) vocabulary learning as well as identifies factors that may play a role in their effectiveness. We found 34 studies with 2,511 participants yielding 49 separate effect sizes. Following the procedure developed by Hunter and Schmidt (2004), we corrected for sample size bias and measurement error. The overall effect size for using technology to learn L2 vocabulary was d = 0.64, which is a moderate effect size. The Q statistic indicated a significant variability in effect size, so we followed up with a theory-driven moderator analysis. The results of the moderator analysis revealed that learners benefited more from technology-assisted L2 vocabulary learning with incidental instruction than with intentional instruction; types of assessment were not significant moderators of the effect on technology-assisted L2 vocabulary learning; technology-assisted L2 vocabulary learning is more effective when the target language is close to the learner’s first language; college students benefited more from technology-assisted L2 vocabulary learning than K–12 students; and, finally, mobile-assisted L2 vocabulary learning was more effective than computer-assisted L2 vocabulary learning.
Association of soybean-based food with the prevalence of anaemia among reproductive-aged men and women in rural Central Java, Indonesia
Authors: Lowe Callum , Sarma Haribondhu , Kelly Matthew , Kurscheid Johanna , Laksono Budi , Amaral Salvador , Stewart Donald , Gray Darren
Published: December 2021

Objective:

To assess the association between soybean consumption and anaemic status in Central Java, Indonesia.

Design:

As part of an overarching sanitation improvement intervention in Central Java, Indonesia, we conducted a cross-sectional study in four rural villages. The study consisted of a 24-h food recall, anthropometric measurements, blood Hb measurement and stool sampling to test for soil-transmitted helminth (STH) infection status. A binary logistic regression model was fitted to test the association between soybean consumption and anaemic status after adjusting for socio-demographic factors, STH infection, dietary diversity and anthropometric status.

Setting:

This study took place in four rural villages of Wonosobo regency, Central Java, Indonesia.

Participants:

Participants were rural villagers aged between 15 and 49 years.

Results:

A total sample size of 763 was attained, of which 231 were anaemic. The prevalence of anaemia was 30·2 % among men and women of reproductive age, and highest among young males. Consumption of soybean was high (79·8 %). After adjusting for covariates, the protective association between soybean consumption and anaemia was statistically significant (AOR = 0·53, 95 % CI = 0·30, 0·95,P< 0·05). There was a positive association with anaemia among underweight (AOR = 2·75, 95 % CI = 1·13, 6·69,P< 0·05) and those with high diet diversity (AOR = 1·40, 95 % CI = 1·00, 1·97,P< 0·05).

Conclusions:

Our results were consistent with studies from other countries finding a protective association between soybean consumption and anaemia. This association appeared stronger for tofu than for tempeh. The prevalence of anaemia in rural Central Java is relatively consistent with nation-wide statistics indicating that interventions targeting anaemia are still largely required.
Pulmonary Guardians and Special Regulatory Devices in the Lung of Nile Monitor Lizard (Varanus niloticus) with Special Attention to the Communication Between Telocyte, Pericyte, and Immune Cells
Authors: Mohamedien Dalia , Awad Mahmoud
Published: December 2021

Monitor lizards are acclimatized to a variety of environments. Most of the monitor species are terrestrial, although there are arboreal and semiaquatic monitors. Such accommodation requires unique cellular structure and regulatory devices in various organs, particularly their lungs. This study aimed to report the pulmonary guardians and special regulatory devices that may guard and promote the function of the lungs of the Nile monitor lizards (Varanus niloticus). Specially structured vessels were recorded in the pulmonary tissue involving atypical glomus vessels, vessels with variable wall thickness, and a venule with specialized internal elastic membrane. Moreover, numerous lung resident guardians could be identified including both alveolar and interstitial macrophages, dendritic cells, mast cells, and B- and T-lymphocytes. Pericytes were demonstrated surrounding the capillary endothelium with a characteristic direct hetero-cellular junction with telocytes. Telocytes established a microenvironment through an indirect hetero-cellular junction with the interstitial macrophage, dendritic cells, and pneumocyte type II. Collectively, these data indicate a significant role played by the specially structured vessels and the resident immune cells in guarding the pulmonary tissue of the Nile monitor lizards and promoting its function. Telocytes are suggested to play a key role in angiogenesis and cellular communication to promote the function of the immune cells.
Linear-Time Temporal Answer Set Programming
Authors: AGUADO FELICIDAD , CABALAR PEDRO , DIÉGUEZ MARTÍN , PÉREZ GILBERTO , SCHAUB TORSTEN , SCHUHMANN ANNA , VIDAL CONCEPCIÓN
Published: December 2021

In this survey, we present an overview on (Modal) Temporal Logic Programming in view of its application to Knowledge Representation and Declarative Problem Solving. The syntax of this extension of logic programs is the result of combining usual rules with temporal modal operators, as in Linear-time Temporal Logic (LTL). In the paper, we focus on the main recent results of the non-monotonic formalism called Temporal Equilibrium Logic (TEL) that is defined for the full syntax of LTL but involves a model selection criterion based on Equilibrium Logic, a well known logical characterization of Answer Set Programming (ASP). As a result, we obtain a proper extension of the stable models semantics for the general case of temporal formulas in the syntax of LTL. We recall the basic definitions for TEL and its monotonic basis, the temporal logic of Here-and-There (THT), and study the differences between finite and infinite trace length. We also provide further useful results, such as the translation into other formalisms like Quantified Equilibrium Logic and Second-order LTL, and some techniques for computing temporal stable models based on automata constructions. In the remainder of the paper, we focus on practical aspects, defining a syntactic fragment called (modal) temporal logic programs closer to ASP, and explaining how this has been exploited in the construction of the solver telingo, a temporal extension of the well-known ASP solver clingo that uses its incremental solving capabilities.
Forgetting in Answer Set Programming – A Survey
Authors: GONÇALVES RICARDO , KNORR MATTHIAS , LEITE JOÃO
Published: December 2021

Forgetting – or variable elimination – is an operation that allows the removal, from a knowledge base, ofmiddlevariables no longer deemed relevant. In recent years, many different approaches for forgetting in Answer Set Programming have been proposed, in the form of specific operators, or classes of such operators, commonly following different principles and obeying different properties. Each such approach was developed to address some particular view on forgetting, aimed at obeying a specific set of properties deemed desirable in such view, but a comprehensive and uniform overview of all the existing operators and properties is missing. In this article, we thoroughly examine existing properties and (classes of) operators for forgetting in Answer Set Programming, drawing a complete picture of the landscape of these classes of forgetting operators, which includes many novel results on relations between properties and operators, including considerations on concrete operators to compute results of forgetting and computational complexity. Our goal is to provide guidance to help users in choosing the operator most adequate for their application requirements.