bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacto del covid-19 al comercio en México
Authors: Magaña Pérez Edith Lorena , Silva Hernández Francisca , Martínez Prats Germán
Published: April 2023

This analysis aims to give an overview of how commerce in Mexico has been affected due to the health crisis caused by the covid-19 pandemic, where it has shown significant changes in the way companies have adapted to the imposed changes by governments and even more importantly changes in consumer tastes and preferences, where the current health contingency has accelerated this transition, attracting a greater number of customers who purchase products through digital platforms. Small companies have been the most affected by registering losses that for some have meant their definitive closure, as they do not have enough capital to cope with the changes, and on the contrary, this has been a great opportunity and excellent support for companies that They have been able to adapt and change sales methods and strategies to achieve a good position in competitive markets, leading to potential economic growth. All the challenges that Mexico has presented are also opportunities that it could use in its favor to achieve economic stability, since other countries currently see Mexico as a platform for their investments. However, it is necessary to reinforce and give security to these investments to consolidate them and thus make the offers more attractive to attract more investors to our country. Also, we will analyze how it has affected families in Mexico, this being an important factor to carry out the trade. A family without employment derived from the current situation is detrimental to companies and in the same way the creation of new jobs offers greater possibilities to acquire products. To complement the topic, a comparison will be made with other similar methodological works, concluding that this crisis has marked an important point in the evolution of the economy in Mexico, with both positive and negative results. After the first case of COVID-19 was known, the first thing that became evident is its easy contagion, since in just three months this virus had reached various countries, generating several questions about a new disease worldwide, based on what above the World Health Organization declares the coronavirus a pandemic on March 11, 2020.
Evaluación de herramientas de software libre, para el sistema operativo Windows, en la adquisición de evidencias de la memoria RAM
Authors: Gutiérrez Oquendo Henry
Published: April 2023

The objective of this article, is to evaluate free software tools of the Windows operating system, for the acquisition of evidence of RAM memory, using the ISO/IEC 25010 standard that defines characteristics and measures of quality of use of a product. The above takes into consideration the technical form for RAM dump analysis and the use of the specific tools DumpIt, FTK Imager, Windows Forensic Toolchest (WFT), OS Forensic and RamCapturer.

In order to guarantee the usefulness of the selected tools, it is contemplated to define, classify, identify, obtain, analyze and interpret results obtained with the Volatility tool, and thus be able to detect which instrument recovers more, the most efficient one that affects the evidence less. The latter is of utmost importance, since a very subtle alteration could change the HASH obtaining large scale problems in a trial.
Impacto de la auditoria operativa aplicada a las empresa
Authors: Santiz Gómez Pedro Antonio
Published: April 2023

Companies always seek that their processes or activities are done safely, efficiently, but above all have control of everything that is carried out within it, having an efficient operational area implies a lot of work which sometimes companies find difficult to do or in all expenses invest their money in this aspect. For this the audit has a branch that is of great help for these problems of the companies since with it it is known if the processes are being efficient, if they are generating benefits to the company improving its effectiveness, as well as the profitability of this, it is the operational audit which is responsible for reviewing that the processes are being well applied, as well as verify that the allocated resources are being used in a reasonable manner for the benefit of the entity. This research will address how the operational audit has helped companies to have better processes by ensuring and constantly verifying that they meet the objectives established by the directive, thus leading to the company being effective, profitable, and competitive.
Impacto de la evasión fiscal a través de las empresas que deducen operaciones simuladas en México
Authors: Hernández Martínez Marcela , Martínez Prats Germán , Silva Hernández Francisca
Published: April 2023

Tax evasion has been a very delicate issue that has existed in recent years because it involves not paying the taxes to which either the person or the company is obliged, so contributions have been affected by presenting monetary losses for this type of crime. One of the most used methods in recent years because of the creation of electronic invoicing has been the purchase of invoices where a non-existent operation is simulated to increase the expenses of the company which causes a reduction in the payment of their taxes. This article will describe how these companies affect contributions, but above all how tax evasion has been able to continue to be carried out with the different security schemes that the tax authority has implemented to avoid them.
Auditoría interna, efectividad en la detección de errores en las empresas
Authors: León Zapata Jacqueline
Published: April 2023

Companies seek to have an always efficient and adequate operation, both externally and internally, the latter being the most important because all the processes carried out within the organization have an impact on its profitability, for them there are various tools that provide adequate control of all the processes carried out within it. But this does not mean that they are free of errors, since these occur frequently within companies due to various factors in which most of the human factor is involved, so it is important to detect them to avoid irregularities in the various processes that are carried out that is why there is the internal audit this is responsible for examining, verify and ensure that everything is done correctly in accordance with the procedures already established as well as the respective rules. This study will address the effectiveness of the application of this audit in companies to detect errors within it. It will be carried out through two methodologies in conjunction with the descriptive and the documentary to reach the objective of the research.
Contabilidad, desarrollo efectivo dentro de las microempresas
Authors: López López Vasti Yamileth
Published: April 2023

Accounting is a science applied to economic areas, where through it the record and financial control of the own resources of a natural or legal person is kept, to which, through accounting tools and systems, they keep their various financial records where they are captured to provide a detailed report of their financial situation where it is made known if it is being profitable, as if it presents losses but above all to help managers make the right decisions for the mutual benefit of the company, the research aims to see how accounting has a positive impact on microenterprises and how through its use in them they improve their processes and have a better management of resources, it will be done by means of a descriptive methodology.
The importance of the regulation of public enterprises
Authors: Ibraimi Xhemazie , Ziberi Besime , Brestovci Albulena
Published: April 2023

The rule of law is a necessary issue for the economic development of a country, while its absence hinders economic development (Krever, 2011). The main aim of this study is to analyze the way of governing and supervising public enterprises in the case of Kosovo. This study shed light on the importance they have in the development and balance of the legal system of a state and a functioning democracy which together enable the preservation, increase of responsibility, and reduction of undue political influence. Good corporate governance following the provisions of domestic law and the lack of political influence of the Government in these bodies is a good signal and indicator for foreign investors and lenders that investing and lending to such companies is safe as the lack of governance enables market disruption while on the other hand deprives citizens of quality public services. Based on ownership, publicly owned enterprises (POEs) are organized into central POEs owned by the Government of Kosovo and local POEs owned by one or more municipalities. The Government and the municipalities exercise their rights in these enterprises through the election of the board of directors (Ministry of Economic Development, 2018). Lack of good governance discourages foreign investors and thus slows down the further evolution of ownership and stagnation in the development of the country’s economy.
A speciation continuum within repeated origin of hypertrophied lips in cyprinid fish from East Africa
Authors: Levin Boris , Komarova Aleksandra , Simonov Evgeniy , Tiunov Alexei , Levina Marina , Golubtsov Alexander , Kondrashov Fyodor , Meyer Axel
Published: April 2023

Trophic specialization plays a major role in ecological speciation.
Multiple adaptive radiations among cyprinid fish of the genus
Labeobarbus were recently discovered in riverine environments of the
Ethiopian Highlands, East Africa. These radiations contain parallel
diversifications of trophic morphology, including thick-lipped or
‘rubberlip’ phenotype, whose trophic function remains largely
unexplored. To test the adaptive value of thickened lips, to identify
the ecological niche of the thick-lipped ecomorphs, and to test of these
ecomorphs are the products of speciation we studied six sympatric pairs
of ecomorphs with hypertrophied lips and the normal lip structure from
different riverine basins. Trophic morphology, diet, stable isotope (15N
and 13C) signatures as well as mtDNA markers and genome-wide SNP
variation were analyzed. Our results show that thick-lipped ecomorphs
partition trophic resources with generalized ecomorphs in only one half
of the examined sympatric pairs despite the pronounced divergence in lip
structure. In these thick-lipped ecomorphs that were trophically
diverged, the data on their diet along with the elevated 15N values
suggest an insectivorous specialization different from the basal
omnivorous-detritivouros feeding mode of generalized ecomorphs. Genetic
data confirmed an independent and parallel origin of all six lipped
ecomorphs. Yet, only one of those six thick-lipped ecomorphs had a
notable genetic divergence with sympatric non-lipped ecomorphs based on
nuclear SNPs data (FST = 0.21). Sympatric pairs can be sorted by
combinations of phenotypic, ecological, and genetic divergence within
the speciation continuum from an ecologically non-functional mouth
polymorphism via ecologically functional polymorphism to completed
speciation via divergent evolution.
An introductory review of the thermal structure of subduction zones: I. Motivation and selected examples
Authors: Keken Peter van , Wilson Cian R
Published: April 2023

The thermal structure of subduction zones is fundamental to our understanding of physical and chemical processes that occur at active convergent plate margins. These include magma generation and related arc volcanism, shallow and deep seismicity, and metamorphic reactions that can release fluids. Computational models can predict the thermal structure to great numerical precision when models are fully described but this does not guarantee accuracy or applicability. In a pair of companion papers the construction of thermal subduction zone models, their use in subduction zone studies, and their link to geophysical and geochemical observations is explored. In part I the motivation to understand the thermal structure is presented based on experimental and observational studies. This is followed by a description of a selection of thermal models for the Japanese subduction zones.
Urban growth analysis using remote sensing and GIS techniques to support decision-making in Algeria-the case of the city of Setif
Authors: Slimani Nabil , Raham Djamel
Published: April 2023

Rapid urbanization in Algeria is causing significant problems, such as the
emergence of unplanned neighborhoods, and local authorities need to apply
modern tools like geomatics to monitor and update spatial planning databases
to support sustainable development. More to the point, these
tools-geographic information systems (GIS) and remote sensing (RS) are of
assistance to update the spatial planning and development database so as to
support the decision-making. In fact, for understanding the purpose of the
process of urban growth in the region of the interior high plateaus, we
chose the city of Setif as it represents an urban and economic pole in the
region. Besides, economic activities exacerbate the phenomenon of rapid and
unplanned urban growth alongside the environmental impact thereof. In the
light of the obtained results, there exists a significant increase in urban
lands and a significant decline in forests and agricultural lands, as the
urban area has tripled from 10.4% in 1985 to 20.3 in 2003 and to 29.7% in
2021. At the same time, the agricultural area has then shrunk from 76.4% in
1985 to 65.8 in 2003 and to 55.5% in 2021, while the forest areas have
decreased from 5.04% in 1985 to 4.4 in 2003 and to 2.3% in 2021.
Use of web-based GIS applications in geography teaching-the implications from Türkiye
Authors: Ocak Fatih , Döker Mehmet , Ünsal Ömer
Published: April 2023

Geography, as a discipline which examines the earth, aims to increase
analytical thinking skills by instilling spatial thinking (ST) skills in
students. The youth who enrich a sense of space with these talents will
effectively solve the spatial problems they encountered. In the modern
world, where spatial issues are frequently being faced with, ST is extremely
important for analyzing and interpreting data. Geographical information
systems (GIS) appear as a method commonly used to process data and transform
it into spatial information. In this context, despite the renewal of the
secondary education (SE) geography curriculum in T?rkiye, with the
components required for the use of GIS at the SE level, prevented the use of
GIS in SE from reaching the desired level. Developments in technologies have
also caused significant changes in the field of GIS with the power of cloud
technologies and, the work done in the personal computer environment has
been moved to the internet environment. Web GIS applications, which can be
used via a web browser, are much easier to use than desktop software and can
reach many users from any device with the internet. Within the scope of the
study, a sample application was designed to use web GIS tools in geography
teaching. With the application, it is possible to assess the students?
achievements in the geography lessons regarding verbal and spatial data.
Thus, it was aimed to ensure the active participation of the students in the
geography lessons, develop their ST ability, and perception of space.
Determination of winter tourism potential areas in Türkiye using a GIS-based multi-criteria analysis
Authors: Uyan Mevlut , Sert Emra , Osmanli Nurullah , Gulmez Kamil
Published: April 2023

Tourism, one of the expeditiously growing and most important sectors,
contributes to the national economy by increasing employment and foreign
exchange income. As in many countries, the place of tourism in the country's
economy is very important in T?rkiye (formerly known as Turkey). As one of
the sources that have contributed significantly to the country's economy for
many years, it has played a locomotive role in its development. T?rkiye is
trying to increase its share of international tourism revenues with
investments and incentives. Although it is a country that draws attention
with its areas suitable for winter tourism, the development of winter
tourism centers is very slow when some aspects are taken into account. Konya
Province is one of the few religious and cultural tourism centers of
T?rkiye. The region has qualified winter tourism areas. Bringing these areas
to tourism can be an important resource for both the provincial and national
economy. This study proposes a Geographical Information System based Multi
Criteria Evaluation (MCE) model using Best Worst Method (BWM) to identify
the most suitable locations for winter tourism facilities in the Konya
region of T?rkiye. Among some suitable areas determined according to the
results of the analysis, Alada? Mountain in Derbent region has been seen as
the most suitable place for winter tourism investments, as it has all the
features such as snow quality, transportation, and snowy day duration that
should exist in a winter tourism center.
Systemic embolic events associated with persistent foramen ovale: A case report
Authors: Kokovic Tijana , Batinic Nikola , Zivanovic Zeljko , Till Viktor
Published: April 2023

Introduction. Embolization into the systemic circulation through the
persistent foramen ovale is known as paradoxical embolization. Coexistence
of paradoxical embolism with pulmonary thromboembolism is rare and it
requires detailed examination. The objective of this study was to present an
unusual case of stroke that was complicated by the occurrence of pulmonary
thromboembolism, with thrombosis of the superior mesenteric artery, and
arterial infarction of numerous visceral organs, a few days after its onset.
Case Report. A 60-year-old female patient was admitted to the Emergency
Center with clinical symptoms of acute ischemic stroke, with sudden left
hemiparesis. Computed tomography showed a fresh ischemia in the basin of the
right anterior cerebral artery. The initial clinical course was favorable,
with gradual regression of neurological symptoms. On the seventh day of
hospitalization, the patient presented with a sudden worsening of symptoms.
Computed tomography confirmed multiple infarctions of the liver, spleen and
both kidneys, partial thrombosis of the superior mesenteric artery, as well
as thrombosis of both pulmonary arteries and two fresh ischemic zones,
namely right temporal and parieto-occipital, cortico- subcortical. A
persistent foramen ovale was found by transesophageal echocardiography,
which also confirmed the existence of an atrial septal aneurysm. In the
further course, there was an improvement of symtoms. The patient was
referred for further rehabilitation therapy. A surgical closure of
persistent foramen ovale was indicated. Conclusion. Paradoxical embolism
remains a pathology rarely mentioned by clinicians, although it can affect
the functional and vital status and prognosis of the patient. Good cardiac
evaluation and detection of persistent foramen ovale in every patient with
embolic ischemia is of great importance.
The experience of cities during the COVID 19 pandemic: What are we going to do now?
Authors: Petrovic Mina , Vukelic Jelisaveta
Published: April 2023

The Covid 19 pandemic, taken as a social crisis, has pointed to the high vulnerability of the basic organizational principles of modern society and the inherent inequalities, particularly those related to the urban space. Therefore, the first part of the paper presents ideas and practices initiated by the Covid 19 pandemic regarding (re)conceptualization of urban mobility and (re)organization of urban spaces in searching for more sustainable and resilient solutions, in Europe and the developed world. Secondly, the analysis addresses ecological modernization and the entrepreneurial (smart) city models as conceptual frames that limit considerably the approach to urban sustainability and resilience, both in general and in a pandemic context. The concluding part highlights the missing political will and economic interest to deal with the pandemic as an opportunity to reset existing urban policies/measures and seek to balance the economic, social and ecological dimensions of urban development. By employing critical sociological thinking on contemporary cities, the authors emphasize the need to recognize social and environmental justice issues in urban sustainability discourse and practice.
Development of Automated Water Delivery System for Microirrigation in Bangladesh for Okra Cultivation
Authors: Zannat Rafatul , Rahman Md. Mostafizar , Akter Sharmin , Rana Md. Masud , Oliver Md. Moinul Hosain , Ali Md. Aslam , Md. Moniruzzaman  , Uddin Md. Zamil , Saha Khokan Kumar
Published: April 2023

Okra is a well-known and economically important vegetable grown in Bangladesh for consumption and seed production. The yield of okra is low compared to developed countries that can be increased using irrigation water efficiently. Traditional irrigation methods are used for okra cultivation in the developing countries, resulting in significant water loss. One of the options that appears to be promising for reducing this water loss is drip irrigation since it applies water directly to the plant’s root zone. However, farmers frequently complain about manual inspection and water wastage from the overhead tanks in small-scale microirrigation systems. An automated microirrigation system can help to solve this problem. This approach was developed at Bangabandhu Sheikh Mujibur Rahman Agricultural University to evaluate the performance of okra in terms of plant growth, seasonal water usage, and yield factors. For a better understanding of specialist crop irrigation management, the effectiveness of water utilization was also investigated. The experimental field was set up in a Randomized Complete Block Design (RCBD) from March to May 2021, with three different treatments such as T1 (Conventional irrigation), T2 (Drip irrigation) and T3 (Timer drip irrigation), for comparing the treatments with four replications. To construct an automated microirrigation system, a pump controller with sensing probes to regulate the water level in the irrigation tank and irrigation timers for watering the okra field depending on scheduling were used. According to the data, only the length of the pod varied significantly, whereas the other factors were non-significant. The yield components, such as the weight of pod per plant and yield, did not varied significantly among the treatments. The highest (12.95 kg/m3) and the lowest (10.47 kg/m3) water use efficiency were obtained in T3 (Timer drip irrigation) and T1 (Conventional irrigation) respectively. The study reveals that automated microirrigation technology can save 11% more irrigation water than conventional irrigation.
Towards Better Balanced IPRs: Improving Access to Health through Better Access to Education
Authors: Jankoska Elena , Ilievski Viktor
Published: April 2023

This is an excerpt from a larger work on biotechnology patents and access to healthcare looking to provide an alternative, rather indirect solution that might improve the whole IPRs environment and ease the longstanding strife between access to health and patent protection.
This paper argues that increase of the overall standard in developing and least developed countries through provision of better education, in turn, supported by IPRs resources, can contribute to better access to healthcare and novel patented medicines.
For this purpose, an analytical method is used going through various approaches to IPRs ranging from public-private interests, information and patents, individualism and IPRs as well as looking into the concept of knowledge economy. Human rights, albeit the common battleground, deserve their rightful place in this paper, however, they are not directly addressed to leave room for the other aspects mentioned. It concludes with the findings that IPRs contribution to education might be beneficial for both IPRs holders and the general society.
This article derives from a doctoral dissertation “Biotechnology Patent Protection in the Information Era” to be defended in the spring term of 2022-2023 at the Istanbul Commerce University (Istanbul Ticaret Üniversitesi).
New Media Disruption Towards Mainstream Media Resistance (Study of Fajar and Tribun Timur Daily in Makassar City)
Authors: Erniwati  , Unde Andi Alimuddin , Cangara Hafied , Hidayatullah Fauzan
Published: April 2023

The phenomenon of disruption penetrates all lines of life. Technological advances influence almost all human activities and activities. Conventional media loyal to their old style will slowly lose their fans. The methodology used in this study is qualitative-descriptive, with a case study approach consisting of several cases in Fajar & Tribun Timur Makassar using a purposive sampling technique. This study's results indicate decreased newspaper readers, but print media advertising growth is still growing. Some factors affected were the decline in circulation turnover triggered by a decline in public interest in reading Beria through print media. The strategy is digitizing newspapers through e-papers, content innovation, networking, and organizational restructuring. The disruption of new media by the Fajar & Tribun Timur newspaper industry managers process opportunities and threats. Opportunities in question are 1) the Strength of human resources in providing accurate information to the public. 2) Establish collaboration with stakeholders. 3) The company's management's Strength in response to journalistic style changes. 4) Technology Development. While the threats faced are 1) The presence of new media. 2) The speed of new media in providing information compared to the mainstream media. 3) High costs and 4) Business competitors. The electronic world is full of creations and cyber-journalistic abilities that can be combined in synergy with print media. This step can only be done if the leadership of this new media is controlled by a team that has technological, management, and cyber journalistic skills that are highly competitive in information competition.
Characterization of somatic and metabolic antigens of Cysticercus cellulosae and determination of immunodominant proteins
Authors:   Department of Veterinary Public Health and Epidemiology, Nagpur Veterinary College, Nagpur, Maharashtra, India, Satyaprakash Kaushik , Ahmed Khan Wiqar , Namdeorao Zade Nandkishor , Prabhakarrao Chaudhari Sandeep , Vasant Shinde Shilpshri
Published: April 2023

The present study shows the characterization of four somatic antigens (Whole Cyst Antigen (WCA), Cystic Fluid Antigen (CFA), Scolex Antigen (SA) and Membrane-Body Antigen (MBA)) and one metabolic antigen (Excretory-Secretory Antigen (ESA)) prepared from Cysticercus cellulosae originated from a naturally infected pig. Immunodominat proteins were determined using hyper immune rabbit sera. The Sodium Dodecyl SulphatePolyacrylamide Gel Electrophoresis (SDS-PAGE) profile of the antigens revealed different numbers and patterns of protein bands in the range of 11.80 to 176.74 kDa. The electrophoretic pattern of ESA also revealed a number of closely placed indistinct bands in the range of 20-34 kDa.. The proteins in the lower molecular weight range (< 30 kDa) in the case of WCA, CFA, ESA, and the medium molecular weight range (30-60 kDa) in the case of SA and MBA were observed to be immunodominant in the Enzyme-Linked Immunoelectrotransfer Blot (EITB) assay. These immunodominant proteins could be further investigated as potential diagnostic antigens in the serodiagnosis of cysticercosis in pigs, and neurocysticercosis in human patients.
Plasma pharmacokinetics and dosage regimen of cefpirome sulfate in ewes
Authors:   Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Banaskantha, Gujarat, India, Sarvaiya Vaidehi N. , Sadariya Kamlesh A. , Bhavsar Shailesh K. , Thaker Aswin M.
Published: April 2023

Cefpirome is fourth- generation cephalosporin class of drug with a broad spectrum of activity against Grampositive and Gram- negative organisms. A pharmacokinetic study of single dose intravenous (IV) and intramuscular (IM) administration of cefpirome sulfate (10 mg/kg body weight) was conducted using High Performance Liquid Chromatography (HPLC) and the pharmacokinetic parameters established were utilized to calculate optimal dosage regimens in ewes. Following IV administration of cefpirome in ewes the mean value of the elimination rate constant (β), elimination half life (t½β), the area under the plasma drug concentration-time curve (AUC0-∞), the area under the first moment of the plasma drug concentration (AUMC), the mean residence time (MRT), the apparent volume of distribution (Vdarea) and total body clearance (ClB) were 0.43 ± 0.04 h-1, 1.68 ± 0.21 h, 82.71 ± 3.76 mg.h/mL, 211.06 ± 23.99 mg.h2 /mL, 2.51 ± 0.19 h, 0.28 ± 0.03 L/kg and 0.11 ± 0.00 L/h/kg, respectively, while following IM administration of cefpirome the mean values were 0.33 ± 0.01 h-1, 2.04 ± 0.06 h, 73.27 ± 4.04 mg.h/mL, 229.02 ± 20.32 mg.h2 /mL, 3.09 ± 0.12 h, 0.45 ± 0.03 L/kg and 0.14 ± 0.01 L/h/kg, respectively. The bioavailability following IM administration of cefpirome was 88.85 ± 4.07 %. Cefpirome concentration in plasma was maintained above the target MIC (≥0.25 mg/mL) for 12 h. The therapeutic dosage regimen calculated using the pharmacokinetic parameters generated by the intravenous route of drug administration indicated the most appropriate dose of cefpirome to maintain MIC at ≥ 0.25 µg/mL with a dosage interval of 12 h, would be 13.00 mg/kg body weight in ewes.
The use of an autologous platelet-rich fibrin (PRF) membrane for the treatment of deep corneal ulcers in dogs
Authors: Demir Aynur , Erdikmen Dilek O. , Sevim Zeynep T. , Altundağ Yusuf
Published: April 2023

The aim of this study was to evaluate the clinical efficacy of a platelet-rich fibrin (PRF) membrane, which is considered to be a new alternative surgical method in the treatment of vision-threatening corneal ulcers in dogs. Fourteen dogs (17 eyes) of various breeds and ages with deep corneal ulcers were treated surgically with a PRF membrane transplantation. The corneal ulcer of all the patients was closed with an autologous platelet-rich fibrin membrane. In the first 10 days after the operation, it was observed that the fibrin membrane partially melted, and corneal epithelialization and granulation tissue occurred in and around the ulcer area due to the graft material. Pain was significantly relieved, and conjunctival inflammation was noticeably improved. From the 20th day after the surgery, the granulation tissue was gradually cleaned. It was determined that all the eyes had vision. The most common complications after surgery were corneal pigmentation and fibrosis of varying severity. The use of autologous fibrin membranes is a safe and effective surgical alternative for the closure and healing of corneal ulcers. Our findings show that the autologous platelet-rich fibrin membrane is useful and effective in treating canine corneal deep ulcers.
Isolation of heterophils from peripheral blood in hens and analysis of heterophil functions by flow cytometry - a methodological study
Authors: Matur Erdal , Erek Mert , Ergen Ezgi , Acar Bolat Bilge , Özcan Mukaddes
Published: April 2023

The aim of this study was to modify the flow cytometric method, which is used for analyzing neutrophils, to analyse the functions of avian heterophils. The blood samples used in the experiments were obtained from hens in slaughterhouses. Blood samples were collected from 10 hens for each trial. Within the scope of the present study, trials were carried out regarding the amount of blood, cell suspension, dihydrorodamine-123 (DHR-123), phorbol-12- myristate-13-acetate (PMA), and N-formyl-methionyl-leucyl-phenylalanine (fMLP), as well as the storage duration of blood samples and incubation time. The results showed that 0.5-3 ml of blood could be used to detect heterophil functions, and it would be ideal to conduct analyses using fresh blood samples. In addition, the results showed that blood stored at +4 °C for up to 8 hours may be also used if necessary. In order to isolate the cells, centrifugation for 30 minutes is sufficient, and it is appropriate to use a 30µL cell suspension. 2µL of DHR-123 should be used as a chemical probe to measure heterophil functions. Excessive use of DHR-123 affected the heterophil functions negatively. In addition, it was observed that using 2µL of fMLP, which is used as an oxidative burst stimulant, and 2µL of PMA as a stimulant of chemotaxic activity, were sufficient. It was concluded that incubation at 41 °C for 5 minutes after stimulating the heterophils is also sufficient. We conclude that the methods established in this study could be used to isolate heterophils and to analyze them by flow cytometry. Therefore, this study would contribute to further research and clinical studies in poultry.
Similarities and differences between vibriosis in European sea bass caused by Vibrio anguillarum and Vibrio harveyi
Authors:   Croatian Veterinary Institute, Department for Fish and Mollusc Diseases, Zagreb, Croatia, Zupičić Ivana Giovanna , Pavlinec Željko , Veić Tina , Oraić Dražen , Zrnčić Snježana
Published: April 2023

Vibrioses caused by different members of the genus Vibrio are common diseases in aquaculture characterised by systemic infections, high mortalities, and economic losses of fish and shellfish. Farming of European sea bass (Dicentrarchus labrax) and gilthead seabream (Sparus aurata) has rapidly grown over the last decade in Croatia but its economic efficacy is significantly jeopardized by losses due to Vibrio anguillarum and Vibrio harveyi infection. Therefore, we studied and compared the most prominent similarities and differences in the environmental conditions, clinical signs and conventional and molecular diagnostic methods of vibriosis caused by both bacterial pathogens. Outbreaks in sea bass and sea bream caused by V. anguillarum mostly occur during the spring and autumn, following a fast increase or decrease in the sea temperature, whereas infections with V. harveyi occur during the summer months at a temperature above 20o C. They have a similar clinical appearance in the acute form but in subacute forms they differ. V. anguillarum infection is characterized by massive haemorrhages in the abdominal wall, while during infection with V. harveyi keratitis, corneal opacity and uncoordinated swimming behaviour are noticed. Necropsy disclosed haemorrhages in the liver, intestine and stomach during infection with V. anguillarum, and sero-catarrhal enteritis with distension of the intestine and ascites in the case of V. harveyi. Although molecular tools enable correct identification, in this study we defined the main differences capable of distinguishing V. anguillarum from V. harveyi based on traditional bacteriological identification such as sensitivity to O/129 (10 µg) and novobiocin, and the enzymatic activity of β-galactosidase, arginine dihydrolase and amygdalin fermentation.
The effect of intra-articular platelet-rich plasma, bio-physically activated PRP and mesenchymal stem cell administration for interleukins in dogs with osteoarthritis
Authors:   Department of Surgery, Faculty of Veterinary Medicine, Selçuk University, Konya, Turkey, Parlak Kurtuluş , Üney Kamil , Uzunlu Elgin Orçum , Yalçin Mustafa , Arican Mustafa
Published: April 2023

The aim of this study was to determine the levels of cytokines (TNF-α, PGE2 , IL-1β, IL-6, IL-10) in synovial fluid samples from joints affected by osteoarthritis (OA), and to assess the efficacy of a single intraarticular (IA) injection of an autologous platelet rich plasma (PRP), mesenchymal stem cells (MSCs), bio-physically activated platelet rich plasma (B-PRP) and their combinations for treatment of OA in dogs. Thirty-six different breeds, gender, age and weight dogs affected by OA were used as materials. The groups were divided into: PRP, MSCs, PRP + MSCs, B-PRP, B-PRP + MSCs and SC (Saline Control). Only one dose was injected. The primary inclusion criterion for the dogs was that they had no systemic disease. The Genesis Cell System was used for preparation of autologous PRP, and the platelets were counted before injection. The Genesis Autologous Cell System 2 (30ml) was used as the bio-physical activator in preparation of the PRP. The bio-PRP physical activator device was mounted on one end and the other end of the activator was left empty. Biovalda Health Technology Inc. was used for producing allogeneic adipose stem cells. Cytokines (TNF-α, PGE2 , IL-1β, IL-6, IL-10) in terms of quantities were measured using enzyme-linked immunosorbent assay (ELISA) from the synovial fluid samples before treatment and on the 0, 15th, 30th, 60th and 90th days of treatment. In all cases, clinic and radiographic examinations were performed on the 0, 15th, 30th, 60th and 90th days. The results obtained from the PRP + MSCs combination group were more successful compared to the other groups. It was noted that successful results could be obtained with PRP alone or in combination with stem cells, especially if repeated intra-articular injections are required. Also future studies are needed to understand the effectiveness of B-PRP. Only the B-PRP and MSCs combination were effective on many enzymes, but varying results were obtained in all cases.
Reporting that meets the needs of the owners of the organization
Authors: Tkachuk N. V.
Published: April 2023

The subject of the study is to find ways to improve the usefulness of accounting data for its owners. The article highlights the interpretation of the concept of «owner of the organization»: the owners of all units of property, only the holders of the right to vote; only shareholder. It is concluded that financial statements are both a mandatory and a voluntary source of information for transactions on the transfer of ownership of a share and share. The situations of using accounting data on a mandatory basis are highlighted: to calculate the actual value of a share when a participant leaves the company or is expelled from it, and on a voluntary basis: to determine the transaction price when buying and selling shares or shares when it is impossible to evaluate the enterprise as a business. The author proved that the principle of conservatism does not allow to calculate the adequate property value of a share or share according to the organization’s financial statements.

It is concluded that the calculation of the actual value of the participant’s share should be based on the assessment of the value of the enterprise as a business. The necessity of harmonization of normative documents regulating the procedure for the functioning of legal entities and the procedure for the formation of financial statements is substantiated.
Flexible, classic and hybrid project management methodologies: advantages and disadvantages
Authors: Nigmatullin R. K. , Dmitriev A. G.
Published: April 2023

The purpose of the work. Nowadays, competition in the market is increasing, which requires organizations to ensure advanced positions for survival. As practice shows, project management method is one of the most demanded and effective management methods. This study aims to examine the efficacy of flexible project management methodologies by contrasting them with conventional methodologies and evaluating the feasibility of integrating them into a hybrid methodology.

Methods and Materials: The complex, systemic and comparative approaches are the methodological basis of the study and are mainly based on methods of analysis and systematization.

Results: The article describes the analysis of the most demanding flexible project management methods. Each method has its own characteristics and specific criteria for comparison. Moreover, a comparison between flexible and traditional project management approaches was carried out, and the concept of method hybridization was introduced to integrate diverse methodologies at distinct phases of the project.

Conclusion: The choice of project management methodology depends on many conditions, such as the complexity of the task, the presence of an experienced team and methodology of its work, the established interaction with the customer, and many other details. Each of them shows its effectiveness under different conditions. Using a hybrid methodology that combines the advantages of different methods allows them to be applied in practice in project management.
Philippine National Rural Development Programs and the ordinary Filipino’s Life Satisfaction
Authors: Melgar Arlette L.
Published: April 2023

This research is about determining the major rural development concept and programs implemented by the national government and how they impact the ordinary Filipino’s life satisfaction. the The study found that (1)The national rural development program is anchored on providing access to financing for agricultural production; (4) A significant part of the national rural development program is for calamity assistance (5) There is a  slow pace of agrarian reform; (6) There is weak job creation in the rural areas thus period 2001-2009 has seen the most Filipinos forced abroad to find work in the country’s history wherein 1.42 million were deployed last year which was equivalent to almost 3,900 Filipinos leaving every day; and (7) There is the whole issue of livelihood sustenance, technical knowhow, technology, competition, cost of production, unpredictable calamities  and most of all, ready markets for the produce in the rural areas.      After twenty (20) years, the ordinary Filipno does not base his life satisfaction on whether or not the national government can develop the rural areas.
A Case of Pediatric Sternal Fracture Diagnosed by POCUS
Authors: Mori Takaaki , Teng Sung Shin
Published: April 2023

A previously healthy, 4-year-old boy visited our emergency department due to chest pain after a fall from a skate scooter. Physical examination revealed tenderness over the sternal body. Point of care ultrasound (POCUS) of the sternum demonstrated a discontinuation of a hyperechoic structure of the sternal cortex, suggesting a sternal fracture. POCUS did not detect intraperitoneal fluid, pericardiac effusion, or pneumothorax. Plain radiograph confirmed the diagnosis of isolated sternal fracture and the patient was discharged with conservative treatment. POCUS was useful not only in diagnosing a sternal fracture but also to rule out concurrent injuries.
A Longitudinal Evaluation of a Multimodal POCUS Curriculum in Pediatric Residents
Authors: Sabnani Reshma , Willard Celia S. , Vega Carolina , Binder Zachary W.
Published: April 2023

Introduction: Pediatric residency programs often do not include a point of care ultrasound (POCUS) curriculum.  We analyzed a novel POCUS curriculum for pediatric residents that incorporated an online question bank (QB), in addition to a traditional teaching model of didactic instruction and hands-on learning experience.  Methods: Four high-yield POCUS topics were chosen: Focused Assessment by Sonography for Trauma (FAST), soft tissue, lung, and cardiac. Residents completed online multiple-choice quizzes before and after each of four in-person learning sessions, taught by ultrasound faculty and fellows.  At the end of the academic year participants completed a knowledge retention quiz. Confidence surveys were administered to participants throughout the course of the study.  Differences in means were compared by Student’s t-test.  Results: Learners demonstrated post-intervention score improvement for each of the four modules.   Retention testing demonstrated retained improvement for the soft tissue and cardiac modules, but not for the FAST module. Self-reported confidence increased across all four topics.  Conclusion: A multimodal POCUS curriculum utilizing a combination of an online QB and in-person teaching demonstrated lasting knowledge for pediatric trainees.
Delayed Iatrogenic Bladder Rupture Diagnosed by POCUS in the Emergency Department
Authors: Lu Helen J. , Lee Edward H. , Alerhand Stephen
Published: April 2023

Bladder rupture is an uncommon injury that leads to significant morbidity and mortality. Though occurring mostly due to trauma, this life-threatening pathology may also occur spontaneously or after a procedure such as transurethral resection of bladder tumor (TURBT). Computed tomography (CT) cystography is the standard imaging modality for diagnosis. However, this test is unlikely to be ordered in a patient with undifferentiated abdominal pain unless there is specific suspicion for this diagnosis. In our emergency department, a 48 year-old male with history of bladder cancer and TURBT two weeks prior to arrival presented with severe abdominal pain and difficulty urinating for 3 days. Point of care ultrasound (POCUS) revealed an irregularly shaped bladder, likely site of bladder rupture, and large amount of abdominal free fluid with sediment. These findings prompted an expedited diagnostic CT scan with cystography. Emergent exploratory laparotomy ultimately confirmed a small bladder defect with 2.5 L of urinary ascites. The diagnosis of non-traumatic bladder rupture can be overlooked in patients presenting with a peritonitic abdominen. The typically ordered test for such patients is standard CT, which carries a high false-negative rate for bladder rupture. This case highlights the utility of POCUS in facilitating a rapid diagnosis.
Varlık Fiyat Balonları ve BIST 100 Volatilitesine Etkisi
Authors: KARCIOĞLU Reşat , AKYOL ÖZCAN Kübra
Published: April 2023

Günümüzde ekonomilerin, işletmelerin başarılı ve sürdürülebilir bir şekilde büyümesi için sermaye piyasaları önem arz etmektedir. Varlık fiyatları alternatif yatırım araçları olmaları yönüyle hisse senedi piyasaları ile etkileşim içindedir. Dolayısıyla varlık fiyatlarında oluşan balonların hisse senedi piyasaları ile ilişki içinde olması beklenmektedir.
Bu çalışmada 08:2010 ile 10:2022 arası aylık verilerle Dolar, Euro, Bitcoin, CDS ve mevduat faizi değişkenlerinde balon varlığı incelenmiştir. Ele alınan değişkenlerde balon oluşumunun varlığı durumunda bu balonların BIST 100 endeksi oynaklığına etkilerinin incelenmesi amaçlanmıştır. Balonların varlığı SADF ve GSADF testleri ile analiz edilirken, TARCH ve ARCH-GARCH modelleri yardımıyla oynaklık belirlenmeye çalışılmıştır. USD, Euro, Bitcoin değişkeni için ele alınan dönem boyunca istatistiksel olarak önemli balon oluşumları söz konusu iken, CDS ve mevduat değişkeni için söz konusu dönemde istatistiksel olarak önemli bir balon oluşumu gözlemlenmemiştir. USD ve Euro değişkenlerinde meydana gelen balonların BIST 100 endeks getirisinde oynaklığı artırdığı söylenebilir. Ancak BITCOIN de yaşanan balonların istatistiksel olarak anlamlı bir etkisinin olmadığı görülmüştür.
EVIDÊNCIAS CIENTÍFICAS RELACIONADAS AOS CONHECIMENTOS, ATITUDES E PRÁTICA DE GESTANTES SOBRE O CONTROLE GLICÊMICO
Authors: De Queiroz Viviane Cordeiro , Andrade Smalyanna Sgren da Costa , Bezerra Iolanda Carlli da Silva , Delmiro Andrezza Rayana da Costa Alves , Da Silva Mirian Alves , Oliveira Simone Helena dos Santos
Published: April 2023

Objetivo: analisar a produção científica acerca do conhecimento, atitude e prática de gestantes sobre o controle glicêmico. Métodos: revisão integrativa da literatura, a partir de artigos publicados no período de 2016 a 2022, nas bases de dados CINAHL, Medline e Web of Science e nas ferramentas de busca PubMed, BVS e Google Scholar. Dos 686 artigos identificados, 19 foram selecionados para compor a presente revisão. Resultados: O conhecimento das gestantes sobre controle glicêmico se mostrou satisfatório quando associado às que já sabiam do diagnóstico da doença. Os Conteúdos mais abordados nos estudos foram manejo da glicemia, efeito materno-fetal, seguimento da dieta, fatores de risco, definição da doença e tratamento.  A atitude e a prática foram insatisfatórias na maioria dos achados, com preocupações centradas na incapacidade de viver uma vida normal no futuro. As principais práticas no manejo da diabetes por gestantes estão relacionadas ao uso da insulina. Conclusão: investimentos em educação em saúde sobre diabetes mellitus gestacional são essenciais para favorecer o autocuidado desde o diagnóstico até o acompanhamento pós-parto, podendo contribuir a prevenção de complicações durante o período gestacional e parto.