bluuebunny/crossref_metadata_2025 huggingface dataset:
Viruses in human brains: a search for cytomegalovirus and herpes virus 1 DNA in necropsy tissue from normal and neuropsychiatric cases
Authors: Taylor G. R. , Crow T. J.
Published: July 2009

Synopsis

DNA was extracted from the brains of patients with Alzheimer-type dementia, schizophrenia, Huntington's chorea and from patients without neurological disease, and examined for the presence of herpes simplex virus type 1 and human cytomegalovirus sequences. By selecting cloned virus DNA fragments which do not hybridize to normal human DNA we were able to achieve a detection level assessed on reconstruction experiments of 1 virus genome per 50 cells. Screening at such sensitivity did not detect virus sequences in the higher CNS, except in cases of encephalitis or immunosuppression. We conclude that, at this level of sensitivity, these viruses cannot be regarded as normal residents of the higher CNS, and at the time of death they do not appear to be associated with these neuropsychiatric conditions.
Dextroamphetamine-induced arousal in human subjects as a model for mania
Authors: Jacobs D. , Silverstone T.
Published: July 2009

Synopsis

Because of the practical difficulties which arise in studying manic patients, a reproducible model for mania using human subjects would be a valuable adjunct to research in this condition. Dextroamphetamine, given as a single oral 20 mg dose, fulfils the criteria for such a model in that there are very close similarities between the changes which occur after dextroamphetamine and those which have been observed in mania in terms of subjective experience, physiological and endocrine changes, and response to pharmacological agents.
Effects of carbamazepine on serum electrolytes in affectively ill patients
Authors: Joffe Russell T. , Post Robert M. , Uhde Thomas W.
Published: July 2009

Synopsis

The effects on serum electrolytes of carbamazepine, an acute and prophylactic treatment for manic-depressive illness, were assessed in subjects with primary affective disorder. Carbamazepine caused statistically significant, but clinically insubstantial, reductions in serum sodium and calcium, but not in the other electrolytes measured. Decreases in serum sodium and calcium were not related to carbamazepine dose, blood levels, or the degree of clinical improvement. The theoretical implications of these findings are discussed.
Patients in receipt of community psychiatric nursing care in Salford 1976–82
Authors: Wooff K. , Goldberg D. P. , Fryers T.
Published: July 2009

Synopsis

Case register data are used to describe the age and diagnostic distribution of people using the community psychiatric nursing (CPN) service in Salford. Data are related to those in hospital-based psychiatric services. Annual prevalence rates grew dramatically, and increasing numbers of people were found to have received continuous CPN care for 2 years and over. Following the establishment of the CPN service in a primary care setting, the proportion of patients suffering from depression in receipt of CPN care increased, and the resulting overall diagnostic distribution of CPN patients became similar to that of the specialist psychiatric services as a whole. Patients under the sole care of community psychiatric nurses (about 19 % of the total CPN prevalence each calendar year) contributed to an overall increase in treated prevalence. The data indicate that CPN services in Salford are treating the morbidity found at primary care level, rather than reducing the demands made on the traditional services.
Task motivation and problem appraisal in long-term psychiatric patients
Authors: MacCarthy Brigid , Benson Julie , Brewin Chris R.
Published: July 2009

Synopsis

Severely handicapped psychiatric patients in long-term day care were questioned about their perceptions of their skills, motivation to perform a range of everyday tasks, current problems and coping strategies. Patients were found to respond reliably and consistently to these questions. It is argued that effective service planning must take account of patients' views of their difficulties and, in particular, of their subjective priorities.
Disorders of facial recognition, social behaviour and affect after combined bilateral amygdalotomy and subcaudate tractotomy — a clinical and experimental study
Authors: Jacobson Robin
Published: July 2009

Synopsis

Synopsis A case of a 37-year-old patient, 10 years after bilateral amygdalotomy and subcaudate tractotomy for chronic self-mutilation, is described. The clinical picture revealed a complex mental state, including disorders of facial recognition, social behaviour, affect and elements of the Kluver–Bucy syndrome. Mild selective deficits were demonstrated psychometrically in the recognition of familiar and unfamiliar faces. Certain features have been described in rhesus monkeys, but have not previously been reported in humans. Primate studies are discussed, with particular reference to the role of the amygdala in facial recognition.
Premenstrual depression, cortisol and oestradiol treatment
Authors: Crammer J. L.
Published: July 2009

Synopsis

A woman with a 5-year history of frequently recurrent depressions responded poorly to the usual antidepressants. She had a raised plasma cortisol and was made worse by progesterone or by ACTH. An oestradiol/testosterone implant every 4 months abolished all symptoms for at least 8 years, and plasma cortisol returned to normal. This case is relevant to an understanding of premenstrual syndromes and the genesis of depressive illness.
Attitudes to psychiatry in doctors at the end of their first post-graduate year: two-year follow-up of a cohort of medical students
Authors: Sivakumar K. , Wilkinson Greg , Toone Brian K. , Greer Steven
Published: July 2009

Synopsis

The significantly favourable changes in medical students' general attitudes to psychiatry which we found after their 8-week clerkship in psychiatry and at the end of their clinical curriculum were not maintained at the end of their first post-graduate year. Three of their specific attitudes to psychiatry changed significantly in an unfavourable direction over this 2-year period. Our findings suggest that, while favourable changes in students' specific attitudes to psychiatry can be found following a clerkship, these attitudes do not seem to endure and, in some cases, they later become less favourable. The results are discussed with reference to the relationships between undergraduate medical training in psychiatry, attitudes to psychiatry, and subsequent career choice, particularly general practice.
Tribulin in post-traumatic stress disorder
Authors: Davidson J. , Glover Vivette , Clow Angela , Kudler H. , Meador K. , Sandler M.
Published: July 2009

Synopsis

Tribulin (endogenous monoamine oxidase inhibitor/benzodiazepine receptor binding inhibitor) output was measured in the urine of 18 patients with post-traumatic stress disorder (PTSD) and 13 controls. The level of the two inhibitory activities was highly significantly correlated in the group as a whole. There was no difference between output of either inhibitor in patients and controls. However, when the PTSD group was subdivided according to various psychometric ratings, a pattern of output did emerge. Levels of both inhibitory activities were higher in agitated compared with non-agitated subjects, and lower in extroverts compared with introverts. This finding supports the view that tribulin output is raised in conditions of greater arousal.
Spatiotemporal memory and rate of forgetting in acute schizophrenics
Authors: Shoqeirat Mohammed A. , Mayes Andrew R.
Published: July 2009

Synopsis

Some schizophrenics show anomalies in the frontal and temporal lobes. It is uncertain whether the cognitive deficits shown by Type I schizophrenics are caused directly by such anomalies, or by a deficit in the exertion of attentional effort. In this study, 16 acute schizophrenics, who broadly fitted the Type I characterization and their controls were given a battery of cognitive tests. The patients were impaired on effort-demanding tasks such as the Wisconsin Card Sorting Test, a verbal fluency test and the WAIS, which are susceptible in varying degrees to frontal, temporal and parietal lobe lesions. Patients were not disproportionately impaired, however, on a test of temporal memory and another of spatial memory, an impairment pattern that selectively reflects frontal and medial temporal lobe lesions respectively, nor were they impaired on a rate of forgetting task sensitive to medial temporal lobe lesions. These tasks were chosen not only because performance on them is selectively sensitive to frontotemporal lobe lesions, but also because it seems to depend on exerting minimum amounts of attentional effort. It is tentatively concluded that the cognitive deficits shown by Type I schizophrenics are caused by a problem in exerting attentional effort of unknown origin.
Urinary monoamines and monoamine metabolites in subtypes of unipolar depressive disorder and normal controls
Authors: Roy Alec , Pickar David , Douillet Patrice , Karoum Farouk , Linnoila Markku
Published: July 2009

Synopsis

An examination was made of urinary catecholamine and metabolite outputs in 28 unipolar depressed patients and 25 normal controls. The total group of depressed patients had significantly higher urinary outputs of norepinephrine (NE) and its metabolite normetanephrine (NM), and significantly lower urinary outputs of the dopamine metabolite dihydroxyphenylacetic acid (DOPAC), than controls. Patients who met DSM-III criteria for a major depressive episode with melancholia (N = 8) had significantly higher urinary outputs of normetanephrine than controls, whereas patients with a major depressive episode without melancholia (N = 7) and dysthymic disorder patients (N = 8) had levels comparable with controls. We postulate that the higher urinary outputs of norepinephrine and its metabolite, normetanephrine, reflect dysregulation of the sympathetic nervous system in depression.
Somatization disorder in a US Southern community: use of a new procedure for analysis of medical classification
Authors: Swartz Marvin , Blazer Dan , Woodbury Max , George Linda , Landerman Richard
Published: July 2009

Synopsis

The authors examine somatization disorder in a community population, using grade of membership analysis, a new multivariate analytical technique for the analysis of medical classification. The technique is used to examine whether somatic symptoms will cluster into a clinical syndrome resembling somatization disorder, as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), if no a priori assumptions are made about the interrelationship of somatic symptoms or their clustering into clinical syndromes. Grade of membershp analysis is applied to all respondents in the US National Institute of Mental Health Epidemiological Catchment Area Project of the Piedmont region of North Carolina reporting three of more somatic symptoms from the somatization disorder section of the Dagnostic Interview Schedule. The analysis indicates that seven ‘pure’ types, roughly analogous to clusters in cluster analysis, best describe the interrelationship of the symptoms included in the analysis. One ‘pure’ type in the analysis is nearly identical to DSM-III somatization disorder and is associated with demographic characteristics consistently found among patients with DSM-III somatization disorder. The present results demonstrate that symptoms associated with this disorder do cluster in a highly predictable fashion and represent a strong validation of the natural occurrence of an entity resembling somatization disorder.
The significance of subtyping tardive dyskinesia: a study of prevalence and associated factors
Authors: Gureje Oye
Published: July 2009

Synopsis

The prevalence of tardive dyskinesia (TD) in 137 Nigerian psychiatric patients was 27%. There were no differences in the prevalence rate between patients with affective disorder and those with schizophrenia. There were also no significant differences between the sexes but a trend for the more severe forms of dyskinesia to be commoner in females was noticed. Demographic, clinical and treatment variables were investigated for association with TD and each of its two putative subsyndromes: orofacial and appendicular dyskinesias. Two cases of severe and persistent tardive dystonia, associated with orofacial TD, were seen in two young adults, one with relatively short exposure to neuroleptics. After initial univariate screening, multivariate statistical methods revealed that different factors were associated with each of the two subsyndromes. While length of hospitalization correlated significantly with orofacial dyskinesia, cumulative duration of exposure to high-potency neuroleptics and number of ECTs received were significantly associated with appendicular TD. Neither age nor sex correlated with either of the subsyndromes. The findings confirm and extend previous observations suggesting that these dyskinesias may involve different pathophysiological mechanisms.
Bipolar II illness: course and outcome over a five-year period
Authors: Coryell William , Keller Martin , Endicott Jean , Andreasen Nancy , Clayton Paula , Hirschfeld Robert
Published: July 2009

Synopsis

A five year semi-annual follow-up of patients with non-bipolar (N = 442), bipolar II (N = 64) and bipolar I (N = 53) major depression tracked the courses of prospectively observed major depressive, hypomanic and manic syndromes. In all three groups, depression was much more likely in any given week than was hypomania or mania. However, during the majority of weeks, no full syndrome was present and none of the groups exhibited evidence of continuing psychosocial deterioration. Though all three groups exhibited similar times to recovery from index and subsequent major depressive episodes, both bipolar groups had substantially higher relapse rates and developed more episodes of major depression, hypomania and mania. The two bipolar groups, in turn, differed by the severity of manic-like syndromes and thus remained diagnostically stable; the bipolar II patients were much less likely to develop full manic syndromes or to be hospitalized during follow-up. In conjunction with family study data showing that bipolar II disorder breeds true, these data support the separation of bipolar I and bipolar II affective disorder.
Herpes simplex virus, cytomegalovirus and Epstein–Barr virus antibody titres in sera from schizophrenic patients
Authors: Delisi Lynn E. , Smith Suzanne B. , Hamovit Joel R. , Maxwell M. Elizabeth , Goldin Lynn R. , Dingman C. Wesley , Gershon Elliot S.
Published: July 2009

Synopsis

Serum antibody titres to herpes-simplex (HSV-1, 2), cytomegalovirus (CMV), and Epstein–Barr virus capsid antigen (EBV-VCA) were determined in 38 unrelated chronic schizophrenic patients, 11 nuclear families with at least 2 schizophrenic members, and 2 control groups. The distributions of antibody titres to herpes simplex and cytomegalovirus were similar among all groups. Patients had higher anti-EBV-VCA titres than non-hospitalized controls; however, hospital staff members in contact with the patients also had significantly higher antibody titres to EBV-VCA. Antibodies to EBV early antigen (EBV-EA) were also determined for 27 unrelated patients and 24 mental hospital employees. The schizophrenic patients had significantly higher antibody titres to EBV-EA than the hospital worker control group. These data do not support the hypothesis that herpes viruses are associated with the aetiology of schizophrenia. Although elevated anti-EBV early antigen titres may suggest persistent active EBV infection, it is unlikely to be related to the aetiology of the disorder, since discordance for EBV seropositivity was present among sibling pairs concordant for schizophrenia.
Verbal and non-verbal recall by depressed and euthymic affective patients
Authors: Calev Avraham , Korin Yaacov , Shapira Baruch , Kugelmass Sol , Lerer Bernard
Published: July 2009

Synopsis

This study uses matched-tasks methodology in order to test memory function in depressed and euthymic patients with major affective disorder. Neither drug-free depressed patients nor lithium-treated euthymic patients show a differential deficit in verbal versus non-verbal recall. However, while euthymic patients show no memory impairment, drug-free depressives do show poor memory functioning. The results support the view that memory deficits observed in affective patients in the depressed state are transient, secondary manifestations of depression and are neither indicative of underlying organic pathology, nor of abnormal hemispheric laterality. This suggests that memory impairment in depression can be treated by treating depressive symptoms, both chemically and behaviourally. The results also support the view that prophylactic lithium treatment has no adverse effects on these memory tasks.
Sex therapy outcome research: a reappraisal of methodology
Authors: Bancroft J. , Dickerson M. , Fairburn C. G. , Gray J. , Greenwood J. , Stevenson N. , Warner P.
Published: July 2009

Synopsis

In the first section a controlled treatment study of male sexual dysfunction is described. ‘Unlucky’ randomization of subjects yielded treatment groups which differed with respect to variables of possible prognostic significance. Hence the results are largely uninterpretable.

In the second section the predominantly negative or inconsistent findings in sex therapy outcome research are reviewed and methodological problems, such as those described in the first part, are considered as possible reasons for these negative findings. The interrelationships are explored between (i) small treatment groups, (ii) prognostic variability, (iii) bias, (iv) power, and (v) small expected treatment effects. A strategy for future research is proposed, with particular emphasis on the recognition and use of relevant prognostic indices.
Idiot savant calendrical calculators: rules and regularities
Authors: Hermelin B. , O'Connor N.
Published: July 2009

Synopsis

The three experiments described aimed to establish whether the achievements of idiot savant calendrical calculators were based solely on rote memory and arithmetical procedures, or whether these subjects also used rule-based strategies. It was found that, although different structural calendar regularities were tested by using differing experimental paradigms, all subjects could at least use some of the rules under investigation. The more cognitively able subjects could make use of all the three structural regularities of the calendar tested here. It was concluded that idiot savant calendrical calculators can use rule-based strategies to aid them in the calculation of the days on which past and future dates fall.
A re-investigation of the behavioural effects of intracerebral injection in marmosets of cytopathic cerebrospinal fluid from patients with schizophrenia or neurological disease
Authors: Baker H. F. , Ridley R. M. , Crow T. J. , Tyrrell D. A. J.
Published: July 2009

Synopsis

In experiments designed to investigate transmission, cerebrospinal fluid (CSF) from patients with schizophrenia or neurological disease (Huntington's disease) which had been found to induce a cytopathic effect (CPE) in human embryonic fibroblast cell culture was injected intracerebrally into common marmosets. Behavioural observations were made on the animals during a period of 2½ years prior to injection and for 2½ years after injection. In an earlier study (Baker et al. 1983 b) we found that animals injected with CPE + ve CSF became progressively more inactive when compared with those injected with non-cytopathic (CPE – ve) CSF from control patients. In the present study we were unable to replicate this finding. No difference in behaviour emerged between animals injected with control CSF and animals injected with CSF from schizophrenics or patients with neurological disease, nor between animals injected with CPE + ve CSF and animals injected with CPE – ve CSF. The numbers of offspring produced and surviving did not differ between the groups. We conclude that the original findings were due to factors unconnected with the nature of the injected material.
The risk of minor depression before age 65: results from a community survey
Authors: Bebbington Paul , Katz Randy , McGuffin Peter , Tennant Christopher , Hurry Jane
Published: July 2009

Synopsis

Data from a general population survey of psychiatric disorder in Camberwell were used to calculate the risk of a CATEGO-defined depressive episode before the age of 65, using a modification of Strömgren's method.

Current depression was defined as cases within the relevant categories of the CATEGO program and at threshold level or above on the Index of Definition (Wing et al. 1978). A past history of depression was elicited using key symptoms such as persistent tearfulness and depressed mood, already enquired after in the course of the PSE, to identify potential episodes, followed by questions to determine accessory symptoms, duration, and degree of social impairment. Clinical judgement was then used to decide whether the disturbance constituted a significant depressive episode.

Risk under one set of assumptions was 46 % for men and 72 % for women. Using another method based on (untenably) conservative assumptions, it became 16 % and 30 % respectively. The status and implications of these high values are discussed, particularly for genetic studies.
Is sex necessarily a risk factor to depression?
Authors: Wilhelm Kay , Parker Gordon
Published: July 2009

Synopsis

To isolate and quantify possible determinants of any increased prevalence of depressive disorders in women we studied a select group of men and women, initially similar in terms of a number of putative social determinants of depression, and reviewed the sample five years later when social role diversity was anticipated. We used the Diagnostic Interview Schedule (DIS) to generate DSM-III and RDC diagnoses to estimate lifetime depressive disorders, and established (via corroborative reports) the likely accuracy of those data. Despite lifetime depression being a relatively common experience, no significant sex differences in depressive episodes were demonstrated, suggesting the possible irrelevance of biological factors in determining any sex difference. As there was not major social role divergence over the five year study, we interpret the lack of a sex difference as a consequence, and suggest that findings support the view that social factors are of key relevance in determining any female preponderance in depression described in general population studies.
Factorial validity of the EE scales
Authors: Parker Gordon , Hayward Linda , Johnston Penny
Published: July 2009

Synopsis

High ‘expressed emotion’ (EE) has been held to be predictive of a poor course in patients with schizophrenia, a finding that has emphasized the predictive validity of the EE measure. We review appropriate research examining properties of the EE measure to suggest that, in particular, little is known about the construct validity of the EE measure. We report a longitudinal study examining three measures of parental style (EE; Parental Bonding Instrument or PBI; and interviewer ratings). By comparing EE scale scores with ratings derived by an interviewer we find support for the accuracy of the process generating EE scale scores, and by factor analytic techniques we examine the factorial (construct) validity of the EE scales. A principal components analysis suggested two other dimensions of relevance in parents involved with a schizophrenic member (vigilance, and acceptance of illness in their child) which may be of value in predictive studies. We examined the capacity of interviewer-generated scores (as a simple clinical rating) and factor scores (as central constructs) to predict the course, and were unable to discriminate ‘relapsers’ and ‘nonrelapsers’ with either predictor.
Anticholinergic-neuroleptic antagonism in terms of positive and negative symptoms of schizophrenia: implications for psychobiological subtyping
Authors: Singh Man Mohan , Kay Stanley R. , Opler Lewis A.
Published: July 2009

Synopsis

In three studies of comparable design, 47 schizophrenics received anticholinergic anti-Parkinsonism (AP) medications for two to four weeks along the course of neuroleptic treatment. Clinical ratings during the AP phase were contrasted against the preceding and following two-week periods on neuroleptic alone, and these changes were analysed for a total of 27 psychopathology dimensions and for clusters of seven positive and seven negative symptoms. Schizophrenics overall exhibited significant exacerbation of total psychopathology, and positive but not negative symptoms. Only those with a predominantly positive syndrome when drug-free were susceptible to AP therapeutic reversal. However, other subgroup analyses revealed worsening of total psychopathology and positive symptoms among catatonic, schizophreniform, chronic, and good outcome cases, but negative symptoms alone were significantly increased among paranoids. The results were not supportive of a positive–negative dichotomy of schizophrenia, but instead suggested a tripartite model: a distinct paranoid group and a division of the non-paranoids into a positive and a negative type.
The buffer theory of social support – a review of the literature
Authors: Alloway Ruth , Bebbington Paul
Published: July 2009

Synopsis

The buffer theory postulates that social support moderates the power of psychosocial adversity to precipitate episodes of illness. In this paper, we review the theory as applied to minor affective disturbances. Research in this area suffers because of the many disparate conceptualizations of social support and the resulting difficulty of deciding on the content of measures. Moreover, the meaning of the term buffering is itself unclear. These problems have not, however, inhibited research, and many cross-sectional and longitudinal studies have now been carried out. Our review leads to the conclusion that evidence for a buffering role of social support is inconsistent, reflecting methodological differences between studies but probably also indicating that buffering effects are not of dramatic proportions. Moreover, it is possible that the observed relationships are the result of spurious association or contamination of measures.
A community mental health survey in Cantabria: a general description of morbidity
Authors: Vázquez-Barquero J. L. , Díez-Manrique J. F. , Peña C. , Aldama J. , Rodríguez C. Samaniego , Arango J. Menéndez , Mirapeix C.
Published: July 2009

Synopsis

A two-stage mental illness survey of a random sample of persons aged 17 years and over from a rural community in Cantabria, Spain, is described. In the first stage newly qualified doctors and final year medical students interviewed 1223 respondents (583 males and 640 females) at their homes, using the General Health Questionnaire (GHQ-60) and other psychopathological and social questionnaires. In the second stage senior psychiatrists carried out an at-home interview on a sample composed of all those who in the first stage scored above the cut-off point on the GHQ, and of a similar number of persons selected at random from two independent batches of below-threshold scorers on the GHQ. Because of this design the prevalence figures have to be weighted in order to represent the whole first stage sample.

Of the total population, 14·7% (8·1% of the men and 20·6% of the women) had psychiatric disorders as defined by the PSE-ID system. In males depression accounted for about twice as many cases as anxiety states, but in females there was a predominance of a combination of anxiety, phobic and obsessive conditions. Men presented a higher prevalence of disorders over the age of 35, with a peak around the age of forty, while in women the rise of prevalence was over the age of 45. There was, however, no significant association with marital status.

Unemployment was related to mental illness in males but not in females, while the reverse was true of the type of work. In both sexes the presence of children under fourteen in the household was not related to a rise in prevalence. Women exhibited a high rate of mental illness in the low educational level and in the low social and religious integration groups, but in men a rise in prevalence was found in the low social status, low educational level and low social integration groups. Lastly, in both sexes the presence of physical illness was related to mental disorders.
Eating behaviour of male racing jockeys
Authors: King Michael B. , Mezey Gillian
Published: July 2009

Synopsis

Jockeys based in racing stables in the Newmarket and Epsom areas of England were screened using the 26-item Eating Attitudes Test. The mean score of the EAT was 14·9, significantly above that reported for males in other studies. The response rate was poor, but 10 jockeys agreed to a full psychiatric and eating interview. The majority of jockeys interviewed reported food avoidance, the use of saunas, and the abuse of laxatives. Diuretics and appetite suppressants were also used. Bingeing was common, but self-induced vomiting was unusual. Current weights were 13% below, and the lowest reported weights 21% below, matched population mean weights. The relationship between these forms of eating behaviour and clinical eating disorders is discussed.
The Gospel Oak Study: prevalence rates of dementia, depression and activity limitation among elderly residents in Inner London
Authors: Livingston Gill , Hawkins Angel , Graham Nori , Blizard Bob , Mann Anthony
Published: July 2009

SYNOPSIS

The steps to setting up a population register of elderly residents are described. Based upon this, 87·2% of the elderly residents of an inner-city electoral area were screened for memory disorder, depression and activity limitation using the Short CARE. Contact with medical and social agencies was also recorded; 4·7% were classed as cases by the dementia diagnostic scale, sufferers being older and not living alone. Of the residents 15·9% were classed as depressed, this state being more prevalent in those not currently married. The depresse were, in contrast to the demented residents, likely to be in recent contact with hospital and general practitioner. Thirty-two per cent of the population showed impairment in daily activity, these individuals were usually older, not married and receiving hospital care. Sleep disorder and compliant of many somatic symptoms were associated with a diagnosis of depression. In contrast, most respondents with a subjective complaint of memory disorder, which was common in this population, were neither suffering from depression nor dementia.

With this accurate sampling frame and a good response rate, the prevalence rate of clinical depression must be seen as disturbingly high. The prevalence rate of dementia approximated to that of other surveys. This study also indicated that general practitioners' lists may be inaccurate and that non-responders to first approaches for interview, although similar in demographic features to those responding, may contain among them many suffering from dementia.
The relationship between social vulnerability and the occurrence of severely threatening life events
Authors: Champion Lorna
Published: July 2009

SYNOPSIS

Research on the role of life events in the onset of depression has suggested that certain vulnerability factors can increase the risk of disorder in the face of a threatening event. The role of vulnerability factors to increase the likelihood of severs events occurring in the first place has remained largelu unexplored. The vulnerability factor which has received the most attention is a lack of social support, particularly lack of a confiding relationship with a husband for women. A reanalysis of a number of published studies is undertaken; this shows that there is a positive relationship between lack of intimacy and the occurrence of adversity. The implications of this finding are briefly discussed, with emphasis on the need for a life-span developmental perspective in future life events research.
Clinical attributes of schizophrenic skin conductance responders and non-responders
Authors: Gruzelier John H.
Published: July 2009

Synopsis

Nurses rated schizophrenics, subclassified upon the basis of the presence or absence of electrodermal orienting responses, with Wittenborn scales. Amongst non-institutionalized patients responders, who are more highly aroused psychophysiologically than non-responders, were more manic, anxious, assaultive and attention-demanding. Amongst institutionalized patients skin conductance levels and spontaneous fluctuations were associated with behaviour of a schizophrenic character.
Modification of the noradrenaline related effects of smoking by beta-blockade
Authors: Carruthers Malcolm
Published: July 2009

Synopsis

Increases in plasma noradrenaline were found in a group of 12 subjects smoking cigarettes. The associated rises in pulse rate, blood pressure and plasma free fatty acids could be prevented by β-blockade with oxprenolol. This inhibition of the peripheral effects of catecholamines did not affect subjective satisfaction, indicating that central effects or other rewards are more important reinforcers. It is suggested that noradrenaline release in the hypothalamus is the final common pathway to pleasure in many situations, including smoking.
Cerebral function and the EEG in psychiatric disorder: a hypothesis
Authors: Shaw J. C.
Published: July 2009

Synopsis

Independent studies which showed a difference between the EEG frequency spectra of test and control groups have been compared. Some of the test groups included schizophrenic patients, others comprised groups with dyslexia, reading disability and left preference. The EEG differences between the test and control groups are shown to be similar across the studies. It is suggested that the common attribute of the test groups relates to the functional organisation of the brain and that investigation of EEG correlates of this phenomenon may be of value to research into the biological basis of psychiatric illness.
Hypotheses linking neuroses with premature mortality
Authors: Sims Andrew
Published: July 2009

SYNOPSIS

The death risk for psychiatric patients has decreased over the last 30 years but still remains higher than that of the general population. The death risk for patients with a diagnosis of neurosis is higher than that for the general population. Previous studies are enlisted to investigate this mortality for socio-economic characteristics, alcohol and drug abuse, psychopathy and accident proneness. Possible psychosomatic aetiology of disease and subsequent death is examined. Psychological theories for premature death are discussed and some recommendations made for future areas of enquiry.
Dream content and daytime attitudes in anxious and calm women
Authors: Gentil M. Lourdes Felix , Lader Malcolm
Published: July 2009

SYNOPSIS

Twenty female anxious neurotic patients were compared with 25 normal female volunteers, divided into a low anxious normal and a high anxious group, with respect to dream report content. Dream reports were analysed using an objective and reliable method and were correlated with the day-time attitudes of the subjects measured by Semantic Differential techniques.

Anxiety levels influenced both dream reporting and dream content. In particular, aggression towards the dreamer was more common in the anxious patients. Significant correlations were found in all groups between dream content and daytime attitudes. The results were consistent with the ‘continuity’ hypothesis of dream function.
Predictors of post-traumatic stress disorder following physical trauma: an examination of the stressor criterion
Authors: Feinstein Anthony , Dolan Ray
Published: July 2009

SYNOPSIS

A prospective study documenting psychopathology was undertaken in 48 subjects exposed to a range of physical trauma, but whose injuries were of similar severity. No support was found for the DSM-III-R view correlating the severity of the stressor with the development of post-traumatic stress disorder (PTSD). Distress post injury (high scores on the impact of event scale), indicative of difficulty with cognitive assimilation of the traumatic event, was found to be highly predictive of psychiatric morbidity and PTSD at 6 months.
Obsessive-compulsive disorder and schizophrenia in three identical twin pairs
Authors: Lewis S. W. , Chitkara B. , Revelely A. M.
Published: July 2009

SYNOPSIS

Three monozygotic twin pairs are described who are concordant for DSM-III-R obsessive-compulsive disorder while being discordant for schizophrenia or schizoaffiective disorder. Follow-up interview showed the non-psychotic co-twins to have schizotypal personality disorder. It is concluded that obsessive-compulsive and schizophrenia-spectrum disorders can truly co-exits, thus supporting diagnostic changes introduced into DSM-III-R, and may in some cases be inherited together.
Dietary and metabolic effects on rhesus social behaviour: neonatal thyroxine reductions
Authors: Chamove Arnold. S.
Published: July 2009

Synopsis

Assessment was made of the behavioural development of 3 monkeys whose levels of thyroxine were reduced by being given 131I and another 3 monkeys given a thyroxine depressant (TCAP) during the first weeks of life and maintained with low thyroxine levels for 3 months. When subsequently tested at normal thyroxine levels, these experimental subjects showed less positive social behaviour when compared with controls. When confronted with unfamiliar monkeys, the two experimental groups were less fearful than controls and also showed a lack of differential responsiveness in varying social situations, suggesting a low level of emotion. A foetal athyreotic group is also described.
The implications of bilingualism in the study and treatment of psychiatric disorders: a review
Authors: De Zulueta F. I. S.
Published: July 2009

Synopsis

This review of the data on bilinguals in relation to hypnosis, psychotherapy and psychotic disorders presents evidence for the bilateral representation of language in the cerebral hemispheres of bilinguals, and outlines possible links between the neuropsychology of psychotic disorders and the lateralization of language in these patients. The relationship between affective states and the retrieval of memories and language is also explored.
The clinical EEG and personality in mentally abnormal offenders
Authors: Howard R. C.
Published: July 2009

Synopsis

A retrospective survey was undertaken of the clinical EEG in a series of consecutive admissions to Broadmoor Special Hospital (N = 265). Following reporting of the records by visual inspection, the EEGs were classified according to 4 descriptive categories: predominantly monorhythmic; low voltage fast, ‘choppy’ dysrhythmic with excess theta; and dysrhythmic with paroxysmal features. The last 3 categories constituted EEG patterns with atypical or anomalous features. The EEGs of patients with high scores on Welsh's MMPI Anxiety scale (‘withdrawers’) were compared with those of patients with low scores (‘approachers’). Lateralization of paroxysmal EEG features was studied with reference to MMPI personality measures (Blackburn's Impulsivity and Sociability and Welsh's Anxiety), legal diagnosis, type of offence, and relationship to victim. The EEGs were studied in a further sample of 29 admissions who had been assessed, using Hare's Research Scale for the Assessment of Psychopathy (Hare, 1980). While the overall incidence of atypical EEG features reported in the present study (around 60% of cases) was comparable with that reported previously for offender populations, they occurred significantly more frequently in ‘withdrawers’ than in ‘approachers’. This suggests that the high frequency of atypical EEG features in abnormal offenders may be due to the preponderance of ‘withdrawers’ in this population. Patients who had committed violent offences against strangers, as opposed to people known to them, tended to have bilateral paroxysmal features in their EEG. High scores on Hare's Psychopathy scale were significantly associated with prominent Posterior Temporal Slow Activity. The study offers some prospect that the combined use of EEG and personality assessments may be of potential value in the assessment of dangerousness.
Hallucinations in children with conduct and emotional disorders: I. The clinical phenomena
Authors: Garralda M. E.
Published: July 2009

Synopsis

In a retrospective study, children referred to the Maudsley Hospital with conduct or emotional disorders who also suffered from hallucinations were found to be older than other children seen with similar diagnoses, more of them had below-average IQs and they were more frequently admitted as in-patients. In most cases hallucinations were auditory. When compared with a group of 20 controls matched on these differentiating features, the 20 children with hallucinations had more precipitants of illness, a shorter duration of the disorder, symptoms of depression, and a family history of mood changes. They also had more symptoms suggestive of cognitive–perceptual dysfunction.
Hallucinations in children with conduct and emotional disorders: II. The follow-up study
Authors: Garralda M. E.
Published: July 2009

Synopsis

In a controlled study, 20 children with hallucinations and emotional or conduct disorders were followed up into adulthood. The mean follow-up time was 17 years and the mean age at follow-up was 30 years. Hallucinations in childhood did not carry an increased risk for psychoses, depressive illness, organic brain damage or other psychiatric disorders. The continuation of hallucinations and episodes of altered awareness in some of the subjects may indicate a special predisposition to hallucinate.
Type A and Type B behaviour patterns, task type and sensitivity to noise
Authors: Moch Annie
Published: July 2009

Synopsis

The present study examined sensitivity to noise in subjects with Type A and Type B behaviour patterns as a function of the type of task being performed. Twenty Type A and 20 Type B subjects, selected by means of Bortner's scale (French version), were exposed to steadily increasing noise levels (68–110 dBA) while performing two tasks. The first was simple (crossing out) and the second was more complex (memorizing nonsense syllables). There was no difference between the groups on the simple task, but on the more complex task Type A and Type B subjects reacted differently, the former maintaining their level of tolerance while the latter lowered theirs. High investment and the desire to succeed may lead Type A subjects to ignore the acoustic environment and/or to deny the aversive aspects of noise as cognitive strategies for coping with stress.
Suicide among psychiatric patients of a district general hospital
Authors: Fernando Suman , Storm Victor
Published: July 2009

Synopsis

Twenty-two psychiatric patients who committed suicide while receiving hospital treatment or within 3 months of discharge from psychiatric care were studied using general population statistics, a random sample of 100 psychiatric patients and a control group matched individually with the hospital suicides. The rate of suicide among psychiatric in-patients was over 50 times that in the general population. A higher vulnerability to suicide was detected among in-patients (v.other patient groups), men (v.women) and middle-aged patients (v.older and younger patients). Suicides were differentiated from controls in having suffered more losses (P< 0·05), being psychiatrically ill for the first time (P< 0·05), having a past history of deliberate self-harm (P< 0·05), and not receiving a schizophrenic diagnosis (P< 0·02). People with mid-life crises, patients who swing rapidly into depression while receiving treatment, and individuals who are judged to be depressed because of personal problems may carry a particularly high suicide risk during psychiatric treatment.
TRH by slow, continuous infusion: an antidepressant?
Authors: Van Den Burg W. , Van Praag H. M. , Bos E. R. H. , Piers D. A. , Van Zanten A. K. , Doorenbos H.
Published: July 2009

Synopsis

A slow, continuous infusion of 1000μg TRH (thyrotropin releasing hormone) over a period of 4 h had a very faint and diffuse short-lasting beneficial effect on a group of 10 depressive patients. This was assessed in a double blind cross-over trial with placebo. The effect was of no therapeutic value. No difference was found between the depressive patients and a control group of normal subjects in TSH response, T3resin uptake, T4or free thyroxine index values as a consequence of the TRH infusion.
Clinical and social variables which differentiate suicide, open and accident verdicts
Authors: Jacobson Solomon , Bagley Christopher , Rehin Ann
Published: July 2009

Synopsis

A study has been made of cases coming before the Brighton coroner in the period 1970–2. Fifty cases in which a suicide verdict was recorded were specially studied, and relatives and acquaintances of the deceased were interviewed. The information thus obtained was compared with information available to the coroner in considering his verdict in 83 further cases in which he made a verdict of ‘suicide’. The reliability of thewhich the coroner's decision is based was largely validated. A study was made of variables which differentiated ‘suicide’ from 25 ‘open’ and 33 ‘accident’ cases considered by the same coroner. The prevalence of depression did not differentiate ‘suicide’ and ‘open’ cases, and this finding contradicts suggestions that the association of depression and suicide might be an artefact of the method of arriving at a suicide verdict. A number of other demographic and clinical factors did however significantly vary between ‘suicide’, ‘open’ and ‘accident’ cases.
Rehabilitation of psychiatric patients who stayed in hospital more than one year
Authors: Sergeant Howard
Published: July 2009

Synopsis

Fewer than one half (238) of a cohort of 489 psychiatric patients who had stayed in hospital more than one year (longstay) were still in hospital three years later. One third of these ‘old’ longstay patients (170) were discharged and resettled – and 81 elderly patients died. During the same three years 1971–3 a further 108 patients became (new) longstay; 57 remained at the end of the study. The discharged patients were neither readmitted unduly often, nor did they become destitute.
Professionalization and narcotics: the medical and pharmaceutical professions and British narcotic use 1868–1926
Authors: Berridge Virginia
Published: July 2009

Synopsis

This paper analyses the influence of medical professional organization on the formation of attitudes and policies towards narcotics in England. Restrictions on sale were one corollary, and the extension of medical control helped delineate a hypodermic morphine problem and disease theories of ‘inebriety’. In the period 1916–26 the Home Office attempted to impose a penal and nonprofessional policy. The 1926 Rolleston Report marked a compromise between medical professionalism and public policy.
N-acetyl-p-amino-phenol (paracetamol, acetaminophen) in the treatment of acute schizophrenia
Authors: Falloon I. , Watt D. C. , Lubbe K. , Macdonald A. , Shepherd Michael
Published: July 2009

Synopsis

The hypothesis that schizophrenia is caused by the release of prostaglandin E into the hypothalamus and may sometimes be accompanied by an elevation of temperature was examined by a clinical trial of the prostaglandin E suppressant N-acetyl-p-amino-phenol (paracetamol, acetaminophen). Ten acute schizophrenic patients were included in a double-blind, crossover trial of paracetamol and a placebo, in which each treatment was given for a week. Regular 4-hourly temperatures were recorded in all these cases and in 5 non-schizophrenic patients for comparison. The findings provided no evidence that paracetamol mitigated the symptoms of schizophrenia. The temperatures of the schizophrenics were not elevated more than those of the controls, but the number of cases used was probably too small for this finding to be conclusive.