bluuebunny/crossref_metadata_2025 huggingface dataset:
Damage maps of façades of a public university
Authors: SANTOS Bruna Letícia Costa , AZEVEDO Vinícius Francis Braga , JÚNIOR José Maria de MOURA , CAVALCANTI Lucas Rodrigues , PÓVOAS Yêda Vieira
Published: April 2023

For a building to perform well during its useful life, it is essential that exist an adequate control during the design and execution phases of the structure, as well as periodic maintenance, over the years, after its construction. The Polytechnic School of Pernambuco (POLI) was founded 110 years ago and consists of several blocks of buildings that were built over the years, therefore, the institution is susceptible to exposure to building defects due to the useful life of the blocks, to the various materials in which they were built and the lack of periodic maintenance. The objective of this research was to carry out the identification of the building defects present on the façades of Block D of POLI and to elaborate their respective damage maps. As a methodology, a case study was carried out, where visual inspections were made through photographic records, then, the elaboration of damage maps through AutoCAD software. After inspection of the façades, the high presence of building defects was identified, especially on the front façade, among which the main ones were peeling paint and dirt. The damage maps made possible to gather the defects present in a relatively precise and easy to understand way, being a fundamental document to help the necessary maintenance of Block D plan, to guarantee its conservation.
Determination of Dominant Phyllosphere Microbial Community in Rubber Trees with Powdery Mildew
Authors: Shan Jiaxin , Wu Hua , Miao Weiguo , Li Xiao , Lin Chunhua
Published: April 2023

Background
Rubber tree powdery mildew is an important fungal leaf disease of rubber tree caused by obligate parasitic bacteria. It is one of the most important diseases in rubber planting areas around the world. The pathogen of rubber tree powdery mildew was previously named Oidium heveae, and its pathogen name is currently Erysiphe quercicola. Leaf-associated microbiomes are currently a new and hot research field for molecular ecology, and the biomass in plant ecosystems is also very large and the biological community is extremely rich.
Results
This study used high-throughput sequencing and other molecular techniques to analyze the structure and diversity of the dominant fungi and bacteria communities of rubber tree leaves in four representative rubber-producing areas in Hainan Province, China (BS, DZ, WN, WZS) after white powder disease occurred. It was found that the dominant bacterial phyla in the four regions were Cyanobacteria, Proteobacteria and Actinobacteria, and the dominant bacterial genus was Cyanobacteria. The dominant fungal phyla in the four regions were Ascomycota, Fungi_unclassified and Basidiomycota.There is significant difference in fungal community composition and relative abundance at genus levels between different areas. We explored the effect of rubber tree powdery mildew on its phyllosphere microbes found that in the same area, there is little difference in community structure between healthy leaves and grade 3 diseased leaves, which only affect the community abundance, while there is significant difference in community composition of different areas. This conclusion also confirms that in the harsh phyllosphere environment, rubber tree phyllosphere microbes need to maintain a good symbiotic relationship with hosts and pathogenic bacteria for surviving and evolving.
Conclusions
This study analyze the structure and diversity of the dominant fungi and bacteria communities of rubber tree leaves in four representative rubber-producing areas in Hainan Province, China after white powder disease occurred. This project the first time to study the influence of Erysiphe on leaf microorganisms of rubber trees. The conclusion confirms that in the harsh phyllosphere environment, rubber tree phyllosphere microbes need to maintain a good symbiotic relationship with hosts and pathogenic bacteria for surviving and evolving.
Partial repair in reinforced concrete using corrosion inhibitor
Authors: Bezerra José Emidio Alexandrino
Published: April 2023

In general, the standards recommend that repairs in places affected by corrosion have done by removing the concrete around the oxidized reinforcement. However, this can pose risks to the integrity of the structure, especially in relation to the pillars, and here, they were present in abbreviated form. To evaluate the difference in effectiveness between the two options for structural repairs, a qualitative laboratory research carried out, based on the variation of corrosion potentials measured with a Cu/CuSO4 semi-cell, in prismatic specimens submitted to corrosion tests induced by chlorides. Then, the use of anodic or cathodic corrosion 'the partial repairs, although they presented inferior results to the total repairs, in relation to the initiation of the corrosion, they are better that the common structural concrete. This, indicating that, they can be a good option for extending the useful life of the structure, with lower risks and costs.
Screening and verification of potential gene targets in the metastasis of breast cancer by bioinformatics analysis and immunohistochemistry
Authors: Wu Qi-Qiao , Liu Kun , Wu Wei-Xun , Liu Juan , Chen Huan , Guan Ying-Ying , Xu Jian-Fang , Sun Jing , Lin Xin
Published: April 2023

BACKGROUND
Breast cancer (BC), one of the most common cancers among females worldwide, has a high mortality rate, especially for patients with BC metastasis. However, BC metastasis pathogenesis has not yet been completely elucidated.
METHODS
We integrated multiple databases to clarify and verify potential key candidate biomarkers and signal transduction pathways in BC metastasis. Differentially expressed genes (DEGs) of breast cancer metastasis and non-metastasis sites were screened using microarray data from three publicly available datasets (GSE14776, GSE103357 and GSE32489). GEO2R, DAVID 6.8, STRING, Cytoscape, GEPIA 2.0 and R 4.0.5 were utilized in this study. The correlations between hub genes and clinical value were validated through the GEPIA online tool, UALCAN and immunohistochemistry (IHC) stain.
RESULTS
A total of 295 DEGs were identified, which were significantly enriched in terms related to focal adhesion, and cell division. KEGG pathway analysis showed that significant pathways included the MAPK signaling pathway, the Rap1 signaling pathway, cell adhesion molecules. Eight hub genes (TYMS, SKA1, ADCY7, POLR3H, CDCA8, PRC1(ASE1), KIF14, and MX1 and two biomarkers (PRC1 and POLR3H) with significantly prognostic values were screened by multi-omics data analysis and verified by IHC stain.
CONCLUSIONS
In this study, we identified a robust set of potential candidate biomarkers in BC metastasis, which would provide potential value for its early diagnosis and prognosis, and would promote molecular targeting therapy for BC metastasis.
Intelligence-learning driven resource allocation for B5G Ultra-Dense Networks: A structured literature review
Authors: Anzaldo Alexis , Rodríguez Marcela D. , Andrade Ángel G.
Published: April 2023

Network densification is a suitable solution to improve the capacity of future mobile networks. However, deploying massive low-power base stations sharing the radio spectrum will cause increased interference reducing the ultra-dense networks (UDN) performance. Resource Allocation (RA) proposals have been developed for decades to meet mobile subscribers' data traffic and QoS demands and to prevent harmful interference. However, as networks evolve and mobile applications request more bandwidth, high data rates, and ultra-reliable low latency, the RA problem has become more complex. Machine Learning (ML) techniques have recently been explored to significantly reduce the computational complexity of RA problems and improve overall UDN performance compared to traditional methods. This paper systematically focuses on the most relevant research contributions that use ML techniques to produce accurate channel and power allocation results in UDN. A total of 56 articles were analyzed from a thorough selection process from manuscripts published from 2010 to 2022 in different academic databases. We describe the main aim of these research works and, according to the ML technique applied, have classified them into ANN-based, RL-based, or DRL-based models. Also, we identify the design features of reinforcement learning strategies used to enhance Key Performance Indicators (KPIs), such as energy and spectral efficiency, throughput, interference, or fairness. Research directions are discussed based on the findings.
Recovering Scientific Literature on COVID-19 using level-based Text Analysis
Authors: Padilla-Cuevas Josu , Cuevas-Rasgado Alma Delia , Reyes-Ortiz José A. , Bravo Maricela
Published: April 2023

The pandemic caused by the SARS-CoV-2 virus has generated numerous scientific texts on the subject, including symptoms, drugs, treatments, and vaccines. These documents are written in natural language and lack a computer-processable structure, which causes a tedious and time-consuming manual analysis. Thus, Information Retrieval (IR) approaches are increasingly necessary to analyse Spanish scientific texts. Therefore, this paper presents approaches based on text analysis levels to retrieve relevant documents about COVID-19 from the Spanish literature. The approaches include preprocessing scientific texts, recovering relevant documents using text analysis levels (probabilistic, similarity, and semantic), and an evaluation process. The main aim of the approaches is to rank the scientific documents considering their relevance to the input question. The evaluation task is done with 100 COVID-19 questions and a dataset of 249,000 scientific texts in Spanish. The results show that the probabilistic approach achieved an F-measure of 85%, supported by document filtering using the Latent Dirichlet Allocation (LDA) algorithm.
Deep Implicit Supervision with Multiscale Feature Mapping for COVID-19 Detection in Chest Radiography Images
Authors: Aloraini Mohammed , Habib Shabana , Albattah Waleed , Alsharekh Mohammed F. , Islam Muhammad , Khan Sheroz
Published: April 2023

The COVID-19 pandemic is considered one of the major outbreaks all over the world, having a serious impact on human health and state economies. One of the important steps involved in fighting against COVID-19 is the early detection of positive patients and keeping them under observation in special care. Detecting COVID-19 from chest X-ray (CX) images is an efficient way to diagnose patients. Therefore, researchers investigated the specific abnormalities in the CX of COVID-19-positive patients. However, the detection accuracy of these methods is not enough for real-time implementation therefore, we develop an effective and efficient model for COVID-19 detection that obtains a better balance among accuracy, specificity, and sensitivity using three benchmark datasets. In the proposed work, a multiscale feature extraction mechanism is used to capture rich spatial information, which improves the discriminative ability of the model to detect COVID-19. Afterward, an implicit deep supervision mechanism is used to increase the interaction among information flows through dense connections. Lastly, a channel attention module selectively highlights the contribution between different feature maps. The experimental results of our model using three benchmark datasets including CXI, XDC, and CRD, demonstrate that our model surpassed the state-of-the-art approaches by achieving higher accuracy, specificity, and sensitivity.
Ficus Lyrata Bark Extract Alleviates Steatosis in Obesity- Induced Non-Alcoholic Fatty Liver Disease in Rats
Authors: Taher Rehab F. , El-Sammad Nermin M. , Mousa Amria M. , Balabel Esraa A. , Youssef Elham M. , Afifi Ahmed H. , Abdel-Rahman Sahar S. , Anwar Nayera , Hassan Sherien K.
Published: April 2023

The authors have requested that this preprint be removed from Research Square.
MicroRNA-485-5p targets keratin17 to regulate pancreatic cancer cell proliferation and invasion via the FAK / SRC / ERK pathway
Authors: Chen Peng , Pan Meng , Shen Zhengchao , Yang Yuquan , Wang Xiaoming
Published: April 2023

It is crucial to probe into the biological effect and mechanism of miRNA-485-5p regulating KRT17 in pancreatic cancer (PC) to understand its pathogenesis and identify potential biological targets. The bioinformatics means were used to evaluate the clinical significance of KRT17 expression in the TCGA database. TargetScan database analysis in conjunction with dual luciferase and RNA Immunoprecipitation (RIP) experiments was used to probe the interaction relationship of miRNA-485-5p with KRT17. The expression of miRNA-485-5p and KRT17 in PC tissue and cancer cell lines was detected by Q-PCR paired with western blot assay. The biological function of miRNA-485-5p in regulating KRT17 was investigated in the PC cell line via gene silencing/overexpression technique. A western blot experiment was utilized to investigate the regulatory effect of KRT17 on cell cycle-related proteins and the FAK/Src/ERK signal pathway. The level of KRT17 was dramatically increased in PC tissues and this significantly decreased the survival rate of PC patients. TargetScan in combination with dual luciferase and RIP experiments verified the miRNA-485-5p target KRT17. The expression of KRT17 was high in the PC cell line, although the expression of miRNA-485-5p was low. Silencing KRT17 or overexpression of miRNA-485-5p significantly inhibited PC cell viability, proliferation, invasion, and colony formation, while promoting apoptosis. In contrast, overexpression of KRT17 drastically reversed the function of miRNA-485-5p. The silenced KRT17 remarkably downregulated the expression of cyclinD1, CDK1, CDK2, p-FAK, p-Src, and p-ERK proteins in the PC cells. Generally, an essential signaling cascade of miRNA-485-5p/KRT17/FAK/Src/ERK influences the biological functions of PC cells.
The Effects of Gender on the Acquisition of English Negative Polarity Items : For Korean Secondary School Students
Authors:   British And American Language And Literature Association Of Korea, Kim Bokyeong
Published: April 2023

In this study, an empirical survey was conducted on Korean secondary school students to understand the effect of gender on the acquisition of English negative polarity items(NPIs). Age and gender were classified to find out the frequency rate of NPIs in the subject and object positions. Looking at the commonalities of male and female students, first, the frequency of NPIs was higher in the object position than in the subject position. These results indicate that Korean secondary school students have a high awareness of NPIs regardless of gender. Second, The frequency of NPIs was high in the first graders, who were in the lowest grade in the subject and object positions. This suggests that age has an effect on the acquisition of NPIs. Looking at the differences between male and female students in acquiring NPIs, a significant difference between first and third graders was confirmed in the case of male students as a result of the post - hoc test in the subject position. In the case of female students, there was no significant difference in subject and object position across all grades. In summary, first, it was confirmed that there was a difference between male and female students in the frequency of NPIs. Second, there was a difference in the frequency rate of NPIs according to the grade. Third, there was a difference in the response rate of NPIs according to subject and object position. It is hoped that the results of this study will serve as a reference for the education of male and female students related to NPIs and negatives in the field of English education. In order to generalize the results of this study, insufficient samples and cases should be supplemented in subsequent studies.
A Melodramatic Failure in All That Heaven Allows
Authors:   British And American Language And Literature Association Of Korea, Choi Jung Sun
Published: April 2023

While examining female liberation and agency in Douglas Sirk’s All That Heaven Allows, this essay furthers the work of Thomas Elsasser and Elizabeth R. Anker to elucidate the ways in which Sirk diverges from melodramatic conventions in the cinematic narrative structure. Moreover, this essay points out the inherent flaw of the melodramatic narrative structure of women’s films. This flaw essentially shows that the suffering female protagonist succeeds in freeing herself by finding a new home, a place of freedom, only to fail in the end because she already knows the reality/the real ending about her inescapable fate. Sirk criticizes the ideological system that shapes and influences gender relations rather than an individual villain. The system that Sirk critiques is one in which women are allowed to transgress and revolt against the assumed oppressor but are simultaneously trained to act docile and accept the supposed inevitable failure of her revolt.
Indian Nationalism and Postcolonial Ethics in Amitav Ghosh’s The Shadow Lines
Authors:   British And American Language And Literature Association Of Korea, Sohn Sukjoo
Published: April 2023

This paper examines the ways in which Amitav Ghosh’s The Shadow Lines portrays the lives of its main characters in terms of ethics and freedom in the aftermath of the partition of India in 1947 and the partition of Pakistan in 1971. Instead of focusing on the binary opposition between nationalism and cosmopolitanism, this research aims to redefine the notion of them, thus raising the need for a new concept of ethics against the background of the historical events in India. By comparing the main characters’ ethical practices in the postcolonial context, the paper shows how cosmopolitanism based on alternative imagination and ethical life can contribute to bringing about the possibility of reconciliation and solidarity between the first world and the third world.
Beyond Ethical Violence to Sympathy for Coexistence: Goerge Eliot’s Middlemarch
Authors:   British And American Language And Literature Association Of Korea, Pyun Kyung - mi
Published: April 2023

This study aims to analyse the vision of sympathy in George Eliot's Middlemarch, reflecting on the singularity of others and common vulnerability in human life discussed in Judith Butler's Precarious life, Giving an Account of Oneself. Middlemarch is set in the fictional provincial village, Middlemarch in England during the early 1830s, the age of English reform. Middlemarch reveals the roots of the precarious lives of Dorothea Brooke and other characters. In other words, it surfaces the process of overcoming ethical violence, which is structured in an imperfect social environment, through sympathy toward others. Further, it focuses on the interdependence and interconnectedness of society and individuals as well as among individuals. Eliot emphasizes sympathy as a medium for emerging from institutionalized ethical violence in society. Eliot resonates with Butler in that the novel explores and urges ways to practice reconciliation and a harmonious life for the coexistence of 'I,' 'you,' and 'us.' For Eliot and Butler, the relationship for a livable life begins with sympathetic imagination that draws attention to the sufferings and losses of others, and common vulnerability of human beings.
Patriotism in Modern Russia: a value criterion of the level of legal consciousness
Authors: Ponedelkov A. V. , Slizovsky D. E. , Shatkovskaya T. V.
Published: April 2023

Patriotism can be valuable only when a person makes certain conscious decisions and takes concrete active actions. Thus, patriotism, like other values, can be realized through awareness of its prescriptive power and its acceptance by a person as a principle of activity. The disclosure of the essence of patriotism by Ivan Ilyin makes it possible to formulate such moral principles as respect, love and pride in one’s motherland. In addition, the essence of patriotism forms the primacy of the national legal culture (but not its exclusivity), uniformity of ways and methods of the spiritual life of the people, preservation of the established spiritual and moral way of Russian life (national character), and peculiar acts of national structure and self-determination. Patriotism also presupposes the unity of the national cultural system and the spiritual and cultural achievements of the people, the creative unity of people in the national culture, the brotherhood of peoples and the inviolability of national autonomous life. The authors proceed from the understanding that the operation of these principles is the basis of state legal consciousness and the unity of the internal life of the state union. Therefore, it requires their recognition, legal protection and regulation at the federal level.
User Request for Content Produced by Female Influencers Online
Authors: Nikolaeva M. V.
Published: April 2023

The article represents the trends in information content, which is produced by the most popular Russian women bloggers. The purpose of the article is to study the discursive fields formed by female influencers in the Russian segment of the online space. Women influencers are able to formulate the gender specificity of published content, which leads to the transformation of discursive fields, first in the online space, and then in offline reality. The main channel of communication between influencers and the target audience is social media, which, on the one hand, provide an illusory freedom of expression, on the other hand, build a new, latently functioning hierarchical system for managing public opinion. Having a direct channel of communication with the audience, female influencers are able to broadcast the gender agenda, reproduce gender stereotypes, fixing them in the existing transit of social action from online to offline space. As a result of the network and linguo-discursive analysis, conclusions were drawn about which discursive fields broadcast by female influencers are the most popular among users, which in the future will not only construct their lifestyle, but also affect the perception of the gender agenda that reveals various aspects of a woman (self-realization, family, career, politics, education, etc.).
Assessment of implementation of smart university management system: The case of Kazakh Ablai Khan University of International Relations and World Languages
Authors: Seitbatkalova Aliya , Tamenova Saltanat , Tarman Bulent , Mukan Saken , Yeralina Elmira
Published: April 2023

The effective functioning of a smart university management system significantly improves higher education institutions’ competitiveness. This study aims to assess the implementation of a smart university management system on the example of Kazakh Ablai khan International Relations and World Languages University. The paper considers elements of a smart university system (smart learning technology infrastructure, smart faculty staff, and smart students) from the university managers’ and students’ viewpoints using the stepwise algorithm to raise the university’s competitiveness. During the study, 2700 students were surveyed to assess the implementation and operation of smart systems at the university, and ten experts (the expert team consists of deans and head of departments) were interviewed to identify the weights of each element. The survey results showed that the technology infrastructure for smart learning at the university is at a lower level (50%) than the competence of the teaching staff (60%) and students (89%). Furthermore, based on standardized factor scores and the weighted average, the implementation level of a smart university management system is low – C (0.498), where the weighted assessment of smart learning technology infrastructure is 0.2, smart teaching faculty – 0.19, and smart students – 0.108. According to the results, the university management needs to develop the smart learning technology infrastructure (free Wi-Fi, smart education environment, and smart classrooms) and improve the qualifications of its teaching staff (knowledge and skills, content of the courses, and educational process).
Functional instant beverages
Authors: Tabakaev Anton , Tabakaeva Oksana , Prikhodko Yury
Published: April 2023

Brown algae are a source of hydrothermal extracts that can serve as an effective raw material for instant beverages. This article offers new formulations of functional instant beverages made of concentrated fruit juices and algal extracts of Saccharina japonica and Sargassum miyabei Yendo. The research objective was to define their bioactive and antioxidant profiles.

The research featured S. miyabei Yendo and S. japonica brown algae from the Far East of Russia, their dry hydrothermal extracts, and instant drinks based on these extracts combined with concentrated juices of cranberry, sea buckthorn, and chokeberry. The list of methods included spectrophotometry, high-performance liquid chromatography, and gas chromatography.

The hydrothermal algal extracts of S. miyabei and S. japonica were rich in fucoidan, phenolic compounds, and iodine. The new instant beverages underwent a sensory evaluation. They contained iodine, phenolic compounds, vitamins (ascorbic acid), fucoidan, pectin, flavonoids, anthocyanins, catechins, carotenoids, and tocopherols. All the samples could be classified as functional, but the best antiradical properties belonged to the sample with black chokeberry juice and S. miyabei.

The new functional instant beverages had a high radical-binding activity, which reached 96.3%. One portion (200 mL) covered 27–30% of the recommended daily intake of iodine and 22–50% of vitamin C. The obtained results prove that instant beverages made of S. japonica and S. miyabei Yendo can be used as functional products.
Staff Potential of the Regional Education System: The Concept and Evaluation Methods
Authors: Morozova Elena , Golubickaya Lyubov' , Kochneva Oksana
Published: April 2023

In many regions, the system of education is experiencing a personnel shortage, both quantitatively and qualitatively. High requirements for teaching staff determine the necessity for thoughtful and scrupulous approach to the development of teachers’ potential. The research aims to define the concept of regional education system personnel potential and develop a system of indicators for its analysis, which is the first step to provide educational institutions with high-quality personnel. Based on the analysis of scientific and methodological sources on the content and structure of human potential, the authors propose definition of regional education system human potential, as well as quantitative and qualitative indicators of its characteristics. Quantitative indicators are analyzed using statistical data, qualitative ones are investigated mainly using sociological and socio-psychological methods..
Russian Bancassurance Market Development in Modern Conditions
Authors: Solovova Aleksandra , Gavrilenko Irina
Published: April 2023

The instability of modern economy forces economic entities to revise their business development strategies and risk management methods. As a result, financial intermediaries (banks and insurance companies) as financial market participants are cooperating to carry out joint activities and solve emerging problems. This leads to the development of bancassurance, one of the most promising ways to advance the Russian financial market. The purpose of the study is to analyze the bancassurance market and identify prospects for its development. The authors provide various definitions for the bancassurance concept, propose a new definition, and consider the interaction models as well as advantages and disadvantages of interaction between banks and insurance companies. To study the bancassurance market the researchers used statistical data of the Central Bank of the Russian Federation and the RAEX Rating Agency for 2012–2020. The authors examined the structure and dynamics of the market as a whole and by segments. The bancassurance accounts for more than a third of the total insurance market volume and continues to grow. The structure of the bancassurance market has radically changed since 2012. The least developed segment is bank risk insurance, most of which is devoted to insurance of bank employees. Non-credit insurance is the most developed, but its share is gradually decreasing. Credit insurance is less developed, but its share is steadily growing due to life and health insurance of consumer loans borrowers..
Areas for Artificial Intelligence Implementation in Kuzbass Healthcare: Sociological Aspects
Authors: Golovko Ol'ga , Kharlampenkov Evgeny
Published: April 2023

The article analyzes the structure of morbidity in the region and identifies the main directions for artificial intelligence implementation in Russia. In order to identify the attitude of clinical physicians towards the artificial intelligence products, the authors performed a sociological survey. To develop the artificial intelligence in the Kemerovo Region it is necessary to use artificial intelligence products and build competence centers for implementing these products in regional healthcare. The main ways of development are strategic programs; creative teams within scientific and educational centers; introduction of automated workplaces for doctors. The authors’ proposals can improve the accuracy of diagnosis, simplify the treatment of patients with various diseases, and rise the healthcare of the Kemerovo region – Kuzbass to a new level.
A Study on the Difference of Comment Use Motivation between Webtoon and Web Novel
Authors:   The Korean Publishing Science Society, Park Seong Eun , Kim Jin Woong
Published: April 2023

The purpose of this study is to investigate the influence of webtoon and web novel users' motivation to use comments (reading) among web contents. As a part of this, we examined the effect of comment use on the relationship between satisfaction and influence, and the relationship between motivation and satisfaction, and examined whether there is a difference between platforms (webtoons and web novels). As a result of the analysis, it was composed of two motives for use (communication, leisure pursuit) and three motives for use of comments (fun to read comments, search for public opinion and information, and criticism) through factor analysis. Both communication motivation and leisure motivation were partially mediated by the relationship between communication motivation and leisure motivation -> fun to read comments -> satisfaction. On the other hand, when comparing the influence of the motivation for using comments between webtoons and web novels, it was analyzed that public opinion, information search and criticism had no mediating effect in common, and the difference was the motivation for reading comments.
Transient Receptor Potential Canonical 5 (TRPC5) Channels Activator,
BTD [N-{3-(adamantan-2-yloxy)-propyl}-3-(6-methyl-1,1-dioxo-2H-1λ6,2,4-
benzothiadiazin-3-yl)-propanamide)] Ameliorates Diabetic Cardiac Autonomic
Neuropathy in Rats
Authors: Sharma Shyam Sunder , Adhya Pratik
Published: April 2023

Background:

Diabetic cardiac autonomic neuropathy (DCAN) is a serious diabetic
complication with no approved pharmacological agents for its treatment. Parasympathetic system
dysfunction characterized by vagal nerve damage is one of the major drivers of DCAN. The
TRPC5 or transient receptor potential canonical 5 channel is a promising target in autonomic
dysfunction; however, its role in vagal nerve damage and subsequent DCAN has not yet been
elucidated. The present study investigated the role of the TRPC5 channel in DCAN using
[N-{3-(adamantan-2-yloxy)-propyl}-3-(6-methyl-1,1-dioxo-2H-1λ6,2,4-benzothiadiazin-3-yl) propanamide)]
or BTD, which is a potent TRPC5 activator.

Objective:

The role of the TRPC5 channel and its activator, BTD, was investigated in the treatment
of parasympathetic dysfunction associated with DCAN.

Methods:

Type 1 diabetes was induced in male Sprague-Dawley rats using streptozotocin. The
alterations in cardiac autonomic parameters in diabetic animals were assessed by heart rate variability,
hemodynamic parameters, and baroreflex sensitivity. TRPC5's role in DCAN was investigated
by treating diseased rats with BTD (1 and 3 mg/kg, i.p. for 14 days). BTD's beneficial effects
in parasympathetic dysfunction were assessed by western blotting, estimating oxidative stress and
inflammatory markers in the vagus nerve.

Results:

BTD treatment (3 mg/kg, i.p.) once daily for 14 days ameliorated heart rate variability,
hemodynamic dysfunction, and baroreflex sensitivity in diseased rats. BTD treatment down regulated
TRPC5 expression by increasing the activity of protein kinase C in the vagus nerve. It also
down-regulated the apoptotic marker CASPASE-3 and also exerted potent anti-inflammatory action
on pro-inflammatory cytokines levels in the vagus.

Conclusion:

BTD ameliorated parasympathetic dysfunction associated with DCAN by virtue of its
TRPC5 modulatory, anti-inflammatory, and anti-apoptotic properties.
Metabolic Associated Fatty Liver Disease in Children and Adolescents:
Mechanisms of a Silent Epidemic and Therapeutic Options
Authors: Mosca Antonella , Volpe Luca Della , Sartorelli Maria Rita , Comparcola Donatella , Veraldi Silvio , Alisi Anna , Maggiore Giuseppe
Published: April 2023

Non-alcoholic fatty liver disease (NAFLD) is now identified as a hepatic sign of meta-
bolic syndrome and is the most frequent cause of chronic liver disease in all ages. It is assumed that
a genetic predisposition associated with epigenetic factors participates in the evolution of this condi-
tion. Visceral obesity and insulin resistance (IR) have always been considered the most important
causative factors of Metabolic Syndrome (MetS) and NAFLD, but currently, the interaction be-
tween genetic heritage and environmental factors is increasingly considered fundamental in the
genesis of metabolic disorders associated with NAFLD. In fact, in patients with NAFLD, insulin resistance, arterial hypertension, abdominal obesity, dyslipidemia and reduced intestinal permeability
have often been found, as well as a higher prevalence of coronary artery disease, obstructive sleep
apnea, polycystic ovary syndrome and osteopenia, which define a MetS framework. Early diagnosis
is needed to prevent disease progression through primarily lifestyle interventions. Unfortunately, at
present, there are no molecules recommended for pediatric patients. However, several new drugs
are in clinical trials. For this reason, targeted studies on the interaction between genetics and envi-
ronmental factors involved in the development of NAFLD and MetS and on the pathogenetic mech-
anisms that determine the evolution in non-alcoholic steatohepatitis (NASH), should be implement-
ed. Therefore, it is desirable that future studies may be useful in identifying patients at risk of de-
veloping NAFLD and MetS early.
ЖИТТЄВІ ДРАМИ ПОВСТАНСЬКОГО ХІРУРГА «ПАСТЕРА» (ЗА МАТЕРІАЛАМИ СУДОВОЇ СПРАВИ ГАЛУЗЕВОГО АРХІВУ СБУ): ДО 80-РІЧЧЯ СТВОРЕННЯ УПА
Authors: І. Д. Любчик
Published: April 2023

Зважаючи на цьогорічні виклики війни і ювілейну дату – 80 річчя з часу створення УПА прагнемо пригадати призабутих повстанських постатей, чия діяльність була зосереджена не стільки на військовій боротьбі – скільки на боротьбі за людське життя. Метою статті є розкрити сторінки життя у повстанському підіпіллі, на той час ще не дипломованого хірурга «Пастера». Вперше намагатимемося це робити, через судову справу Олексія Миколайовича Зеленюка, з галузевого архіву СБУ в Івано- Франківській області. Його життя це драма нескореного українця, який народився на Вінничиі, вчився і розпочав свою лікарську практику на Одещині, він повстанську боротьбу з окупаційними режимами у білому халаті на Станіславщині (нині Івано-Франківщина), а після тяжких по- невірянь у засланні продовжив свою лікарську діяльність на Львівщині.

Ключові слова: Українська повстанська армія, «Пастер», Олексій Зеленюк, хірург, повстанський шпиталь, Червоний хрест, Прикарпаття
Фотолюминесценция в композитах на основе поливинилденфторида и наполнителя CaGa-=SUB=-2-=/SUB=-S-=SUB=-4-=/SUB=-:Eu-=SUP=-2+-=/SUP=-
Authors: Тагиев О.Б. , Асадов Е.Г. , Казымова Ф.А. , Ибрагимов Т.Д. , Рамазанова И.С. , Нуралиев А.Ф.
Published: April 2023

The excitation and photoluminescence spectra of composites based on PVDF and filler CaGa2S4:Eu2+ were not measured at room temperature. The photoluminescence spectra were analyzed at different concentrations of Eu2+ ions and it was found that the position of the maximum of the PL spectra does not change with an increase in the content of Eu2+ ions in the compound, and the maximum of the PL spectrum in all percentages is ~550 nm with the electronic transition 4f 65d1 → 4f 75d.
A Breath of Fresh Air - Lung Transplantation Has Come of Age
Authors: Keshavamurthy Suresh , Russell Cody
Published: April 2023

A boundless spectrum of chronic lung diseases is said to effect over 500 million persons globally. Lung transplantation is a well-established therapeutic option for patients suffering from end-stage lung diseases, however waitlist mortality and primary graft failure remain major determinants as post-transplantation 5-year survival is just above 50 percent. Recent innovations in lung transplantation have been aimed at increasing organ availability, improving allograft quality, function, and longevity. Ex-vivo Lung Perfusion (EVLP) is an exciting modality responsible for multiple paths of lung allograft reconditioning as well as significantly extending preservation times. Mechanical circulatory support (MCS), specifically extracorporeal membrane oxygenation (ECMO) has consistently gained popularity not only for its use as a bridge to transplantation, but also its intraoperative role. In tandem, EVLP and ECMO have shown promising results in increasing the number of lung transplantations performed, therefore decreasing waitlist mortality. Primary graft dysfunction (PGD) and chronic lung allograft rejection (CLAD) continue to be the most feared predictors of poor outcomes. In this review we will highlight the historical progression of lung transplantation, its encumbrance, and the most recent advancements in promising techniques for long-term allograft protection and patient survival.
Measuring levels of hormones in osteoporosis Iraqi women patients
Authors: Kareem Juhi Ali , Abdul- Razzaq Al-Faraji Aliaa Saadoon
Published: April 2023

This study was conducted to investigate the effect of the hormone progesterone and testosterone on osteoporosis in women, and it was found that there are statistically significant differences between the hormone progesterone and there are no statistically significant differences for the hormone testosterone. The ELISA method measured the testosterone concentration in the blood and the progesterone concentration. The purpose of the study measuring the levels of some hormones in osteoporosis Iraqi women patients. Fifty (50) women patients with osteoporosis were admitting Baghdad Teaching Hospital with osteoporosis and 40 healthy populations, and it was conducted in Baghdad Teaching Hospital/ Bone density examination unit/ in Baghdad-Iraq. Endocrine testing Estrogen content was measured following the manufacturer's instructions using available human Uno ELISA kits (Immunolab GmbH, Kassel, Germany). Results showed a significant difference (P-value of 0.0038) in progesterone between the two study groups. The mean of patient groups was mean±SD (6.759 ± 6.705), and control groups were mean±SD (11.03 ± 6.546). The main risk factor for osteoporosis is the presence of more progesterone when comparing patients with healthy women. As for testosterone, there are no significant differences; that is, it does not affect women

Keywords: ELISA Technique, progesterone, testosterone
The Impact of Secure Messaging in the Treatment of Patients With Diabetes Within a Primary Care Setting: Protocol for a Scoping Review
Authors: Lawal Abdul , Menon Devidas , Affleck Ewan , Stafinski Tania
Published: April 2023

Background

Diabetes—a high-burden chronic disease—requires lifetime active management involving the use of different tools and health care resources to improve patient health outcomes. Recent studies have demonstrated promising results regarding the impact of the use of virtual care technology on the treatment of chronic diseases, such as diabetes. However, it is unclear whether the use of technologies, such as secure messaging, improves the quality of care and reduces diabetes-related costs to the health care system.

Objective

The purpose of our scoping review is to explore what is known about the use of secure messaging in the treatment of diabetes within the primary care setting and how its impact has been assessed from the patient and health system perspectives. Our review aims to understand to what extent secure messaging improves the quality of diabetes care.

Methods

Our scoping review will follow the 6-step Arksey and O’Malley methodological framework, as well as the Joanna Briggs Institute methodology for scoping reviews and their recommended tools. The tools to guide the development and reporting of the review in a structured way will include the Population, Concept, and Context framework and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines and checklist. The search strategy was developed iteratively in collaboration with a professional information specialist. Furthermore, a peer review of electronic search strategies was also conducted by an independent, third-party, professional information specialist. A systematic literature search will be conducted against databases, including Ovid MEDLINE ALL, Embase, APA PsycINFO, Cochrane Library on Wiley, CINAHL on EBSCO, and PubMed. Grey literature sources will also be searched for relevant literature. Literature on the use of secure messaging in the treatment of diabetes (types 1 and 2) within a primary care setting will be included. Two reviewers will review the literature based on the inclusion criteria in the following two steps: (1) title and abstract review and (2) full-text review. Discrepancies will be discussed to reach consensus where possible; otherwise, a third reviewer will resolve the dispute.

Results

The results and a final report are expected to be completed and submitted to a peer-reviewed journal in 6 months.

Conclusions

The review will examine existing literature to identify the impact of secure messaging in diabetes treatment within primary care settings. Research gaps will also be identified to determine if there is a need for further studies.

International Registered Report Identifier (IRRID)

DERR1-10.2196/42339
Community Collage Service (KKN) student assistance to improve women's health by detecting breast cancer and cervical cancer in Amansari Village, Karawang Regency
Authors: Widianti Dini , Yusnita Yusnita , Komalasari Rita
Published: April 2023

Non-communicable diseases are responsible for 71% of the premature deaths worldwide. Unfortunately, 77% of those deaths occurred in the developing countries including Indonesia. In response, universities can provide potentially empowering health promoting programs for tackling the risk factors of non-communicable diseases. This study was aimed to explain the process of how to empower universities for tackling these non-communicable diseases’ risk factors through the Health Promoting University (HPU) program. This study was a descriptive study. The population included Indonesian universities that were involved in the HPU development program in 2019-2021 in collaboration with Universitas Gadjah Mada and The Ministry of Health Republic Indonesia. Sample subjects were the total population of 40 universities. Data were collected through observations, unstructured interviews, and documents. Observations were performed in 25 universities. Meanwhile, unstructured interviews were conducted with 34 respondents. Data were analyzed descriptively. The process of the HPU development and the focus programs were varied. Many factors contributed to the process of the HPU development, such as the HPU development strategies, the university leaders’ commitment, networking, social capital, and participants’ capacity in the health promotion. According to the HPU development process from 2019-2021, the HPU development strategy performed in 2021 was the most structured and comprehensive. The capacity building, mentoring system, leader commitment, and networking strongly contributed to the success of the HPU development. This study emphasizes the importance of the university leaders’ awareness toward health and the potential resources of the university for tackling the risk factors of the non-communicable diseases.
Assessing the acceptability of the health education program in Dengue prevention and control in Buon Ma Thuot city in Dak Lak province, Vietnam
Authors: Pham Giang Huong
Published: April 2023

Dengue fever is a serious human arboviral infection that globally spreads and is a top concern amongst health care professionals and governments including Vietnam. The best measure to prevent and control dengue is vector control which is supported by social mobilization and health education. This study assessed the acceptability of health education programs in dengue fever prevention and control for the first time in Dak Lak Province, which is located in the endemic area of dengue fever in Vietnam. This study was an implementation research with qualitative methods. Nine in-depth interviews and six focus group discussions involving thirty-four informants were conducted at province, district, and ward levels. The acceptability was analyzed based on the seven components of the Theoretical Framework of Acceptability. Thirty-four informants ranging from ages 26 to 54 years participated. All belonged to the delivering or receiving groups of the health education program. The years of experience of the delivering group were at least two years with the health education program in dengue prevention and control and all individuals in the receiving group participated in the program. Six components, namely affective attitude, perceived effectiveness, intervention coherence, ethicality, and self-efficacy, were coded in all transcripts. Meanwhile, none of the interviews mentioned the opportunity cost. Overall, the acceptability of the health education program in dengue fever prevention and control was considered to be positive. However, the transformation from education to behavior requires time for acceptance and the persistence of the education program. Besides, the major burden of the program was the limited budget that could lead to inadequate facilities for indirect communication and low human resources.
Development of an emergency volunteer-based call center for COVID-19 within the university setting
Authors: Qaimamunazzala Hayu
Published: April 2023

In response to concerns in the general public due to the Coronavirus Disease 2019 (COVID-19) pandemic, Universitas Gadjah Mada established a COVID-19 call center with the aid of volunteers. This study aims to describe the experience of developing and implementing an emergency volunteer-based call center addressing questions on COVID-19 by a higher academic institution along with the frequency and characteristics of the received calls in 2020. This descriptive observational study was conducted using secondary data to describe the implementation of a call center on COVID-19 at Universitas Gadjah Mada (UGM) between March and December 2020. Data were collected from organization documents and the caller response database. The data were analyzed descriptively. The development process included system development, volunteer recruitment, online training, and implementation. The volunteers logged a total of 150 calls during the 10-month study period. The highest frequency of calls was in March 2020 with 35 calls and the lowest was in August 2020 with only 3 calls. The majority of callers were from Yogyakarta and members of the UGM community. The main issues raised by callers were people seeking general information regarding COVID-19, recommendations regarding their health status, government and university policy related concerns, and logistics. Tele-outreach is a beneficial method to address public distress during a global pandemic, which could be managed with the aid of trained volunteers.