bluuebunny/crossref_metadata_2025 huggingface dataset:
Cu1−Fe Dual Sites for Superior Neutral Ammonia Electrosynthesis from Nitrate
Authors: Zhou Biao , Yu Linghao , Zhang Weixing , Liu Xupeng , Zhang Hao , Cheng Jundi , Chen Ziyue , Zhang Hao , Li Meiqi , Shi Yanbiao , Jia Falong , Huang Yi , Zhang Lizhi , Ai Zhihui
Published: May 2024

The electrochemical nitrate reduction reaction (NO3RR) is able to convert nitrate (NO3−) into reusable ammonia (NH3), offering a green treatment and resource utilization strategy of nitrate wastewater and ammonia synthesis. The conversion of NO3− to NH3 undergoes water dissociation to generate active hydrogen atoms and nitrogen‐containing intermediates hydrogenation tandemly. The two relay processes compete for the same active sites, especially under pH‐neutral condition, resulting in the suboptimal efficiency and selectivity in the electrosynthesis of NH3 from NO3−. Herein, we constructed a Cu1‐Fe dual‐site catalyst by anchoring Cu single atoms on amorphous iron oxide shell of nanoscale zero‐valent iron (nZVI) for the electrochemical NO3RR, achieving an impressive NO3− removal efficiency of 94.8 % and NH3 selectivity of 99.2 % under neutral pH and nitrate concentration of 50 mg L−1 NO3−−N conditions, greatly surpassing the performance of nZVI counterpart. This superior performance can be attributed to the synergistic effect of enhanced NO3− adsorption on Fe sites and strengthened water activation on single‐atom Cu sites, decreasing the energy barrier for the rate‐determining step of *NO‐to‐*NOH. This work develops a novel strategy of fabricating dual‐site catalysts to enhance the electrosynthesis of NH3 from NO3−, and presents an environmentally sustainable approach for neutral nitrate wastewater treatment.
Site‐Selective Distal C(sp3)−H Bromination of Aliphatic Amines as a Gateway for Forging Nitrogen‐Containing sp3 Architectures
Authors: Chen Jinhong , Tan Clarence , Rodrigalvarez Jesus , Zhang Shuai , Martin Ruben
Published: May 2024

Herein, we disclose a new strategy that rapidly and reliably incorporates bromine atoms at distal, secondary C(sp3)−H sites in aliphatic amines with an excellent and predictable site‐selectivity pattern. The resulting halogenated building blocks serve as versatile linchpins to enable a series of carbon‐carbon and carbon‐heteroatom bond‐formations at remote C(sp3) sites, thus offering a new modular and unified platform that expediates the access to advanced sp3 architectures possessing valuable nitrogen‐containing saturated heterocycles of interest in medicinal chemistry settings.
A Hybrid Orbitrap‐Nanoelectromechanical Systems Approach for the Analysis of Individual, Intact Proteins in Real Time
Authors: Neumann Adam P. , Sage Eric , Boll Dmitri , Reinhardt‐Szyba Maria , Fon Warren , Masselon Christophe , Hentz Sébastien , Sader John E. , Makarov Alexander , Roukes Michael L.
Published: May 2024

Nanoelectromechanical systems (NEMS)‐based mass spectrometry (MS) is an emerging technique that enables determination of the mass of individual adsorbed particles by driving nanomechanical devices at resonance and monitoring the real‐time changes in their resonance frequencies induced by each single molecule adsorption event. We incorporate NEMS into an Orbitrap mass spectrometer and report our progress towards leveraging the single‐molecule capabilities of the NEMS to enhance the dynamic range of conventional MS instrumentation and to offer new capabilities for performing deep proteomic analysis of clinically relevant samples. We use the hybrid instrument to deliver E. coli GroEL molecules (801 kDa) to the NEMS devices in their native, intact state. Custom ion optics are used to focus the beam down to 40 μm diameter with a maximum flux of 25 molecules/second. The mass spectrum obtained with NEMS‐MS shows good agreement with the known mass of GroEL.
A Cyclometalated Ruthenium(II) Complex Induces Oncosis for Synergistic Activation of Innate and Adaptive Immunity
Authors: Feng Tao , Tang Zixin , Shu Jun , Wu Xianbo , Jiang Hui , Chen Zhuoli , Chen Yu , Ji Liangnian , Chao Hui
Published: May 2024

An optimal cancer chemotherapy regimen should effectively address the drug resistance of tumors while eliciting antitumor‐immune responses. Research has shown that non‐apoptotic cell death, such as pyroptosis and ferroptosis, can enhance the immune response. Despite this, there has been limited investigation and reporting on the mechanisms of oncosis and its correlation with immune response. Herein, we designed and synthesized a Ru(II) complex that targeted the nucleus and mitochondria to induce cell oncosis. Briefly, the Ru(II) complex disrupts the nucleus and mitochondria DNA, which active polyADP‐ribose polymerase 1, accompanied by ATP consumption and porimin activation. Concurrently, mitochondrial damage and endoplasmic reticulum stress result in the release of Ca2+ ions and increased expression of Calpain 1. Subsequently, specific pore proteins porimin and Calpain 1 promote cristae destruction or vacuolation, ultimately leading to cell membrane rupture. The analysis of RNA sequencing demonstrates that the Ru(II) complex can initiate the oncosis‐associated pathway and activate both innate and adaptive immunity. In vivo experiments have confirmed that oncosis promotes dendritic cell maturation and awakens adaptive cytotoxic T lymphocytes but also activates the innate immune by inducing the polarization of macrophages towards an M1 phenotype.
Unraveling the Unique Strong Metal‐Support Interaction in Titanium Dioxide Supported Platinum Clusters for the Hydrogen Evolution Reaction
Authors: Luo Zhouxin , Han Xiao , Ma Zhentao , Zhang Bingxing , Zheng Xusheng , Liu Yongfeng , Gao Mingxia , Zhao Guoqiang , Lin Yue , Pan Hongge , Sun Wenping
Published: May 2024

Strong metal‐support interaction (SMSI) is crucial to modulating the nature of metal species, yet the SMSI behaviors of sub‐nanometer metal clusters remain unknown due to the difficulties in constructing SMSI at cluster scale. Herein, we achieve the successful construction of the SMSI between Pt clusters and amorphous TiO2 nanosheets by vacuum annealing, which requires a relatively low temperature that avoids the aggregation of small clusters. In situ scanning transmission electron microscopy observation is employed to explore the SMSI behaviors, and the results reveal the dynamic rearrangement of Pt atoms upon annealing for the first time. The originally disordered Pt atoms become ordered as the crystallizing of the amorphous TiO2 support, forming an epitaxial interface between Pt and TiO2. Such a SMSI state can remain stable in oxidation environment even at 400 °C. Further investigations prove that the electron transfer from TiO2 to Pt occupies the Pt 5d orbitals, which is responsible for the disappeared CO adsorption ability of Pt/TiO2 after forming SMSI. This work not only opens a new avenue for constructing SMSI at cluster scale but also provides in‐depth understanding on the unique SMSI behavior, which would stimulate the development of supported metal clusters for catalysis applications.
Photoinitiated Transient Self‐Assembly in a Catalytically Driven Chemical Reaction Cycle
Authors: Valera Jorge S. , López‐Acosta Álvaro , Hermans Thomas M.
Published: May 2024

Chemically fueled chemical reaction networks (CRNs) are essential in controlling dissipative self‐assembly. A key challenge in the field is to store chemical fuel‐precursors or “pre‐fuels” in the system that are converted into activating or deactivating fuels in a catalytically controlled CRN. In addition, real‐time control over catalysis in a CRN by light is highly desirable, but so far not yet achieved. Here we show a catalytically driven CRN that is photoinitiated with 450 nm light, producing activated monomers that go on to perform transient self‐assembly. Monomer activation proceeds via photoredox catalysis, converting the monomer alcohol groups into the corresponding aldehydes that self‐assemble into large supramolecular fibers. Monomer deactivation is achieved by organometallic catalysis that relies on pre‐fuel hydrolysis to release formate (i.e. the deactivating fuel). Additionally, irradiation with 305 nm light accelerates the release of formate by photo‐uncaging the pre‐fuel, leading to a factor of ca. 2 faster deactivation of the monomer. Overall, we show transient self‐assembly upon visible light photoactivation, and tunable life‐times by ultraviolet light.
Enhanced Electron Delocalization Induced by Ferromagnetic Sulfur doped C3N4 Triggers Selective H2O2 Production
Authors: Xu Siran , Yu Yue , Zhang Xiaoyu , Xue Dongping , Wei Yifan , Xia Huicong , Zhang Fuxiang , Zhang Jia‐Nan
Published: May 2024

For the 2D metal‐free carbon catalysts, the atomic coplanar architecture enables a large number of pz orbitals to overlap laterally, thus forming π‐electron delocalization, and the delocalization degree of the central atom dominates the catalytic activity. Herein, designing sulfur‐doped defect‐rich graphitic carbon nitride (S‐Nv‐C3N4) materials as a model, we propose a strategy to promote localized electron polarization by enhancing the ferromagnetism of ultra‐thin 2D carbon nitride nanosheets. The introduction of sulfur (S) further promotes localized ferromagnetic coupling, thereby inducing long‐range ferromagnetic ordering and accelerating the electron interface transport. Meanwhile, the hybridization of sulfur atoms breaks the symmetry and integrity of the unit structure, promotes electron enrichment and stimulating electron delocalization at the active site. This optimization enhances the *OOH desorption, providing a favorable kinetic pathway for the production of hydrogen peroxide (H2O2). Consequently, S‐Nv‐C3N4 exhibits high selectivity (>95 %) and achieves a superb H2O2 production rate, approaching 4374.8 ppm during continuous electrolysis over 300 hour. According to theoretical calculation and in situ spectroscopy, the ortho‐S configuration can provide ferromagnetic perturbation in carbon active centers, leading to the electron delocalization, which optimizes the OOH* adsorption during the catalytic process.
High anticancer activity in short response time exhibited by a new azobenzene derivative and its copper complex
Authors: Dev Samrat , Mitra Debarpan , Sinha Chittaranjan , Das Gaurav , Murmu Nabendu , Maity Amit Ranjan , Pandey Souvik
Published: May 2024

o‐Aminoazotoluene (OAT), capable of photoisomerization, and o‐vanillin, a potent comutagen, have been used to synthesize a new ligand, HL, [C6H4(CH3)N=NC6H3(CH3)N=CHC6H3(OH)(OCH3)], which, upon complexation with copper(II), results in a new copper(II) complex‐Cu(L)2, [Cu{C6H4(CH3)N=NC6H3(CH3)N=CHC6H3(OCH3)O}2]. Both HL and Cu(L)2 have been characterized by single‐crystal X‐ray diffraction measurements along with other analytical techniques, for example, IR spectroscopy, NMR spectroscopy, UV–Vis spectroscopy, elemental analysis and mass spectrometry. These compounds were tested with different in vitro anticancer assay as well as with in silico studies. A comparative study has been demonstrated on anticancer activity of HL and Cu(L)2 with the ligand HAZ, {C6H5N=NC6H4N=CHC6H3(OH)(OCH3)} and its Cu‐complex, [Cu(AZ)2, Cu{C6H5N=NC6H4N=CHC6H3(OCH3)O}2]. The sensing properties of HAZ, along with the synthesis and structural properties of both HAZ and Cu(AZ)2, have been reported by our group earlier. Cytotoxicity measurements on MCF7 cell lines show that Cu(L)2 and Cu(AZ)2 have higher anticancer activity than their corresponding ligands. The apoptotic effect of Cu‐complex was studied through nuclear fragmentation assay and AO/EB dual‐staining assay on MCF7 cell line. The IC50 value of Cu(L)2 in 0.01% DMSO/water after 24‐h treatment was found 4.2 μM, which is one of the lowest values with this response time compared to the other analogous anticancer compounds. Finally, we have evaluated the expression of hERα protein with respect to Cu‐complexes, and it was observed that Cu(L)2 caused more down‐regulation of hERα as compared to Cu(AZ)2.
Tough bilayer thermo‐responsive hydrogel actuator reinforced by Fe3+ complexation
Authors: Tian Shilin , Wang Ziquan , Wang Xusheng , Yang Feng , Shi Hongqi , Wen Huimin , Shen Tianyu , Zhu Zhenkun , Wang Yangxin , Zhao Huaixia
Published: May 2024

Hydrogel actuators usually suffer from the poor mechanical property, which hinders their wide applications. In this study, we propose a tough bilayer hydrogel actuator that can respond quickly to temperature. The hydrogels are composed of poly(N‐isopropylacylamide) (PNIPAM) layer and poly(acrylamide‐co‐acrylic acid) (P(AAm‐co‐AAc)) layer strengthened through Fe3+ complexation with carboxyl groups. By optimizing the PNIPAM content, the resulting bilayer hydrogel P(NIPAM0.9/AAm‐co‐AAc)‐Fe3+ exhibits fast and large‐amplitude bending and recovery in response to temperature. It also shows excellent mechanical properties with a tensile strength of 2.54 MPa, tensile modulus of 3.7 MPa, and toughness of 9.4 MJ/m3, respectively. Besides, the multiple noncovalent interactions within the hydrogels, including Fe+‐mediated coordination and hydrogen bonds, can serve as dynamic but stable associations, leading to a good self‐healing ability. The bilayer hydrogel is further made into a gripper that can effectively and sensitively respond to temperature to capture and release an object, showing its potential application in artificial intelligent devices.
Pure Green Ag–In–Ga–S/Ga–S Quantum Dot Light‐Emitting Diodes with Electron Transport Materials Exhibiting Enhanced Luminescence Properties
Authors: Motomura Genichi , Ohisa Satoru , Uematsu Taro , Kuwabata Susumu , Kameyama Tatsuya , Torimoto Tsukasa , Fujisaki Yoshihide
Published: May 2024

Quantum dots (QDs) are essential luminescent materials with applications in wide‐color‐gamut displays requiring exceptional color reproducibility. Multinary semiconductor QDs composed of groups I, III and VI elements are expected to serve as eco‐friendly materials to replace conventional QDs owing to the potential narrow spectral widths and tunable bandgaps of the former. Although optimized Ag–In–Ga–S/Ga–S core/shell QDs (AIGS QDs) have exhibited vibrant green emissions, electroluminescence from QD‐based light‐emitting diodes (QLEDs) incorporating these AIGS QDs is reduced as a consequence of the effects of defect sites. The present work therefore examines the incorporation of electron transport materials (ETMs) into AIGS QD emitting layers. A device incorporating emitting layers composed of AIGS QDs and 2,4,6‐tris(3‐(3‐pyridyl)phenyl)‐1,3,5‐triazine (TmPPyTz), with the latter acting as a highly conductive ETM, exhibits a low driving voltage and high efficiency. Furthermore, the addition of two ETMs — TmPPyTz and tris(2,4,6‐trimethyl‐3‐(pyridin‐3‐yl)phenyl)borane — is found to provide enhanced luminescence properties because these materials are deposited in the emitting layer in different forms and hence has varying effects in terms of improving conductivity and charge balance. The resulting QLEDs have a sharp spectral width of 30 nm, suggesting a level of color purity suitable for wide‐color‐gamut displays.
Unlocking the therapeutic potential of TRPV3: Insights into thermosensation, channel modulation, and skin homeostasis involving TRPV3
Authors: Lei Jing , Tominaga Makoto
Published: May 2024

Recent insights reveal the significant role of TRPV3 in warmth sensation. A novel finding elucidated how thermosensation is affected by TRPV3 membrane abundance that is modulated by the transmembrane protein TMEM79. TRPV3 is a warmth‐sensitive ion channel predominantly expressed in epithelial cells, particularly skin keratinocytes. Multiple studies investigated the roles of TRPV3 in cutaneous physiology and pathophysiology. TRPV3 activation by innocuous warm temperatures in keratinocytes highlights its significance in temperature sensation, but whether TRPV3 directly contributes to warmth sensations in vivo remains controversial. This review explores the electrophysiological and structural properties of TRPV3 and how modulators affect its intricate regulatory mechanisms. Moreover, we discuss the multifaceted involvement of TRPV3 in skin physiology and pathology, including barrier formation, hair growth, inflammation, and itching. Finally, we examine the potential of TRPV3 as a therapeutic target for skin diseases and highlight its diverse role in maintaining skin homeostasis.
The use of bioluminescent enzyme bioassay for the analysis of human saliva: Advantages and disadvantages
Authors: Kolenchukova Oksana A. , Dedora Anastasia O. , Stepanova Lyudmila V. , Kravchuk Vlada U. , Kratasyuk Valentina A.
Published: May 2024

The purpose of the work was to find optimal conditions for bioluminescent enzymatic analysis of saliva (based on the use of NADH:FMN oxidoreductase + luciferase) and then to determine the biological effect of using bioluminescence assay of saliva to study the physiological state of the body under normal and pathological conditions. The saliva of snowboarders and students were studied in the “rest–training” model. The saliva of patients diagnosed with acute pharyngitis was examined in the “sick–healthy” model. Bioluminescence assay was performed with a lyophilized and immobilized bi‐enzyme system using cuvette, plate, and portable luminometers. The concentrations of secretory immunoglobulin A (sIgA) and cortisol were determined by enzyme immunoassay, and the total protein content was measured by spectrophotometric method. The activity of the bioluminescent system enzymes increased as the amount and volume of saliva in the sample was decreased. The cuvette and plate luminometers were sensitive to changes in the luminescence intensity in saliva assay. Luminescence intensity correlated with the concentrations of sIgA and cortisol. The integrated bioluminescent index for saliva was reduced in the “rest–training” model and increased in the “sick–healthy” model. Thus, the non‐invasive bioluminescent saliva analysis may be a promising tool for assessing the health of the population.
A carbon dot‐based time‐dependent color‐changing room temperature phosphorescent material with facile synthesis
Authors: Zhang Le , Bian Zhentao , Hu Guangzhou
Published: May 2024

Carbon dots have attracted widespread attention due to their excellent optical properties and so on and are therefore used in various fields such as anti‐counterfeiting. There are many reports on carbon dot‐based room‐temperature phosphorescent materials, but there are still fewer reports on carbon dot‐based room‐temperature phosphorescent materials with time‐dependent color‐changing properties. In this work, a time‐dependent color‐changing carbon dot‐based room‐temperature phosphorescent material with the ability to change from green to blue was successfully prepared by a simple one‐pot heating method using hydroxyurea as the only raw material. In this process, hydroxyurea is used as both a carbon and nitrogen source, and in the process of material formation, hydroxyurea also partially forms cyanuric acid as a matrix to make the carbon dots uniformly dispersed in it. By blending the ratio of the dual emission centers of the carbon dots themselves, the final effect of time‐dependent color‐changing is achieved by taking advantage of the intensity changes and color differences of each emission center. The present work provides new ideas for the preparation of time‐dependent color‐changing carbon dot‐based room‐temperature phosphorescent materials.
Clinical relevance of somatic mutations in Chinese lung adenocarcinoma and their prognostic implications for survival
Authors: Li Tongxin , Liu Jie , Zhou Yu , Huang Shengyuan , Wang Dong , Chen Jianrong , Fu Yong , He Ping
Published: May 2024

Background

To comprehensively elucidate the genomic and mutational features of lung cancer cases, and lung adenocarcinoma (LUAD), it is imperative to conduct ongoing investigations into the genomic landscape. In this study, we aim to analyze the somatic mutation profile and assessed the significance of these informative genes utilizing a retrospective LUAD cohort.

Methods

A total of 247 Chinese samples were analyzed to exhibit the tumor somatic genomic alterations in patients with LUAD. The Cox regression analysis was employed to identify prognosis‐related genes and establish a predictive model for stratifying patients with LUAD.

Results

In the Dianjiang People's Hospital (DPH) cohort, the top five frequent mutated genes were (Epidermal growth factor receptor) EGFR (68%), TP53 (30%), RBM10 (13%), LRP1B (9%), and KRAS (9%). Of which, EGFR is a mostly altered driver gene, and most mutation sites are located in tyrosine kinase regions. Oncogene pathway alteration and mutation signature analysis demonstrated the RTK‐RAS pathway alteration, and smoking was the main carcinogenic factor of the DPH cohort. Furthermore, we identified 34 driver genes in the DPH cohort, including EGFR (68%), TP53 (30.4%), RBM10 (12.6%), KRAS (8.5%), LRP1B (8.5%), and so on, and 45 Clinical Characteristic‐Related Genes (CCRGs) were found to closely related to the clinical high‐risk factors. We developed a Multiple Parameter Gene Mutation (MPGM) risk model by integrating critical genes and oncogenic pathway alterations in LUAD patients from the DPH cohort. Based on publicly available LUAD datasets, we identified five genes, including BRCA2, Anaplastic lymphoma kinase (ALK), BRAF, EGFR, and Platelet‐Derived Growth Factor Receptor Alpha (PDGFRA), according to the multivariable Cox regression analysis. The MPGM‐low group showed significantly better overall survival (OS) compared to the MPGM‐high group (p < 0.0001, area under the curve (AUC) = 0.754). The robust performance was validated in 55 LUAD patients from the DPH cohort and another LUAD dataset. Immune characteristics analysis revealed a higher proportion of primarily DCs and mononuclear cells in the MPGM‐low risk group, while the MPGM‐high risk group showed lower immune cells and higher tumor cell infiltration.

Conclusion

This study provides a comprehensive genomic landscape of Chinese LUAD patients and develops an MPGM risk model for LUAD prognosis stratification. Further follow‐up will be performed for the patients in the DPH cohort consistently to explore the resistance and prognosis genetic features.
Outcomes of pirtobrutinib for relapsed/refractory mantle cell lymphoma in compassionate use program in Europe
Authors: Aydilek Enver , Wulf Gerald , Schwarz Friedrich , Bacher Ulrike , Rummel Mathias , Stiefel Olga , Kerkhoff Andrea , Maulhardt Markus , Melchardt Thomas , Pabst Thomas , Lenz Georg , Shumilov Evgenii
Published: May 2024

Background

Mantle cell lymphoma (MCL) is a type of B‐cell lymphoma that is currently incurable. Pirtobrutinib shows promising response rates in heavily pretreated MCL patients according to the approval study, but the real‐world data are scarce.

Methods

In this study, we retrospectively analyzed the efficacy and safety profile of pirtobrutinib in 10 relapsed/refractory MCL patients from compassionate use program (CUP).

Results

On average, the patients underwent three lines of systemic therapy prior to pirtobrutinib and were predominantly BTKi exposed (9/10). The best overall response rate (BORR) was 67%. In a median follow‐up of 8.6 months, the mean duration of response (DOR), progression‐free survival (PFS), and overall survival (OS) were not reached. No new safety signals were documented.

Conclusions

In summary, pirtobrutinib represented a safe and effective treatment option in a small real‐world population.
Clinicopathological features, prognostic factor analysis, and survival nomogram of patients with double primary cancers involving lung cancer
Authors: Hao Yuxuan , Zhang Xiaoye , Cui Guoyuan , Qi Xiaoying , Jiang Zhongxiu , Yu Li
Published: May 2024

Background

Although the incidence of double primary cancers (DPCs) involving lung cancer is rising, they have not been studied sufficiently. This study retrospectively analyzed the clinicopathological and prognostic characteristics of DPC patients with lung cancer and developed a survival nomogram to predict the individual OS rates.

Methods

We included 103 DPC patients with lung cancer from Shengjing Hospital between 2016 and 2021. Based on the 6‐month cancer occurrence interval, the cases were categorized as synchronous DPCs (sDPCs) or metachronous DPCs (mDPCs). Furthermore, the mDPCs were subdivided based on whether the lung cancer occurred first (LCF cohort) or the other cancer occurred first (OCF cohort).

Results

Among the patients, 35 (33.98%) and 68 (66.02%) had sDPCs and mDPCs, respectively. In the mDPCs cohort, 18 (26.47%) belonged to the LCF cohort and 50 (73.53%) to the OCF cohort. The most frequent primary cancer sites were the breast (27.18%), colorectum (22.33%), and urinary system (18.45%). Independent risk factors for progression‐free survival were Stage IV lung cancer (p = 0.008) and failure to undergo radical lung cancer surgery (p = 0.028). The risk factors for OS included squamous carcinoma (p = 0.048), Stage IV lung cancer (p = 0.001), single cancer resection plus drug therapy (p < 0.001), drug therapy alone (p = 0.002), failure to undergo radical lung cancer surgery (p = 0.014), and chemotherapy (p = 0.042). The median OS was 37 months, with 3‐ and 5‐year rates of 50.9% and 35.9%, respectively.

Conclusion

DPCs involving lung cancer account for 1.11% of cases. The breast, colorectum, and urinary system were the most common extra‐pulmonary sites, and mDPCs were more frequent than sDPCs. Radical lung cancer surgery significantly affects prognosis, and drug therapy alone may be preferable when only one tumor is operable. The developed nomogram can accurately predict individual 3‐year and 5‐year OS rates.
Laburnicolamine: A Rare Penillic Acid Congener from the Nematode Cyst‐Associated Fungus Laburnicola nematophila
Authors: Wennrich Jan‐Peer , Holzenkamp Caren , Ashrafi Samad , Maier Wolfgang , Wang Hao , Ibrahim Mahmoud A. A. , Ebada Sherif S. , Stadler Marc
Published: May 2024

A chemical investigation of a methanol extract derived from a solid‐state rice culture of the nematode‐cyst associated fungus Laburnicola nematophila K01 led to the isolation and characterization of a previously undescribed penillic acid analogue named laburnicolamine (1). The chemical structure was elucidated through comprehensive 1D and 2D NMR spectroscopic analyses in methanol‐d4 and DMSO‐d6, alongside with HR‐ESI‐MS spectrometry. The absolute configuration of 1 was concluded through the electronic circular dichroism (ECD) and time‐dependent density functional theory‐ECD (TDDFT‐ECD) computations compared to its acquired spectrum. Biological assays revealed that compound 1 exhibited no significant cytotoxic, antimicrobial, or nematicidal activity.
Electrochemically Enhanced Forward Osmosis Processes Unlocking Efficiency and Versatility
Authors: Yang Euntae , Kim Chang‐Min , Ahmad Ishaq , Jee Hobin , Song Seunghyun , Park Chanwoo , Jung Yudam , Kang Dohyoung , Chae Kyu‐Jung , Kim In S.
Published: May 2024

The growing interest in forward osmosis (FO) for water reclamation and desalination over the past two decades stems from its potential for lower energy consumption. Despite its promise, FO faces significant challenges, such as the lack of an appropriate draw solute, concentration polarization, membrane fouling, and reverse solute flux (RSF). Recent trends in research have focused on combining various technologies with FO to address these challenges. Notably, the integration of electrochemical technologies with FO offers new possibilities. This review covers FO combined with electrochemical cells (FO‐ECs), categorizing them based on their working principles and applications in improving FO. The review discusses different FO‐EC configurations, including (1) electrodialysis‐combined FO for RSF, (2) electro‐FO for water flux enhancement, and (3) electrochemical oxidation‐combined FO and FO with electro‐conductive membranes for self‐cleaning and fouling mitigation. Additionally, it covers (4) reusable electro‐responsive draw solutes, (5) electrochemical osmosis systems for metal removal and energy production, and (6) osmotic microbial fuel cells for energy recovery and other benefits. The review also assesses the practical applicability and potential for achieving carbon neutrality of the FO‐ECs. It concludes with a forward‐looking perspective, outlining future research directions to optimize and expand the use of electrochemical‐enhanced FO technologies.
Synthetic Strategies to Extended Aromatic Covalent Organic Frameworks
Authors: Prieto Tania , Ponte Clara , Guntermann Roman , Medina Dana D. , Salonen Laura M.
Published: May 2024

π‐Conjugated materials are highly attractive owing to their unique optical and electronic properties. Covalent organic frameworks (COFs) offer a great opportunity for precise arrangement of building units in a π‐conjugated crystalline matrix and tuning of the properties through choice of functionalities or post‐synthetic modification. With this review, we aim at summarizing both the most representative as well as emerging strategies for the synthesis of π‐conjugated COFs. We give examples of direct synthesis using large, π‐extended building blocks. COFs featuring fully conjugated linkages such as vinylene, pyrazine, and azole are discussed. Then, post‐synthetic modification methods that result in the extension of the COF π‐system are reviewed. Throughout, mechanistic insights are presented when available. In the context of their utilization as film devices, we conduct a concise survey of the prominent COF layer deposition techniques reported and their aptness for the deposition of fused aromatic systems.
Similarities and Differences of Hydridic and Protonic Hydrogen Bonding
Authors: Lamanec Maximilián , Zienertová Jitka , Špeťko Matej , Nachtigallová Dana , Hobza Pavel
Published: May 2024

Ab initio calculations were employed to investigate the interactions between selected electron‐donating groups, characterized by M−H bonds (where M represents a transition metal and H denotes a hydridic hydrogen), and electron‐accepting groups featuring both σ‐ and π‐holes. The study utilized the ωB97X‐D3BJ/def2‐TZVPPD level of theory. Hydridic hydrogen complexes were found in all complexes with σ‐ and π‐holes. A comparative analysis was conducted on the properties hydridic H‐bond complexes, presented here and those studied previously, alongside an extended set of protonic H‐bonds complexes. While the stabilization energies changes in M−H bond lengths, vibrational frequencies, intensities of the spectral bands, and charge transfer for these complexes are comparable, the nature of hydridic and protonic H‐bonds fundamentally differ. In protonic H‐bond complexes, the main stabilization forces arise from electrostatic contributions, while in hydridic H‐bond complexes, dispersion energy, is the primary stabilization factor due to the excess of electrons and thus larger polarizability at hydridic H. The finding represents an important characteristic that distinguishes hydridic H‐bonding from protonic H‐bonds.
Psychotherapy on an Acute Psychiatric Ward: Preliminary Findings From a Controlled Study
Authors: Cohen‐Chazani Yael , Igra Libby , Hamm Jay A. , Leonhardt Bethany L. , Klion Reid , Cheli Simone , Hasson‐Ohayon Ilanit
Published: May 2024

This study investigated the efficacy of psychotherapy during hospitalization on an acute psychiatric ward. A controlled trial was conducted to assess the effects of Metacognitive Reflection and Insight Therapy (MERIT) upon metacognition and psychiatric symptoms. Data from 40 inpatient women were analysed. Findings included significant interaction effects between group (intervention or control group) and time (preintervention and postintervention) in regard to the metacognitive abilities and general psychiatric symptoms. Participating in MERIT seems to improve one's ability to use reflective knowledge to cope with psychological challenges and to improve symptomatology level.
Oral Drug Dosing After Gastric Bypass and Diet‐Induced Weight Loss: Simpler Than We Think? Lessons Learned From the COCKTAIL Study
Authors: Kvitne Kine Eide , Hjelmesæth Jøran , Hovd Markus , Sandbu Rune , Johnson Line Kristin , Andersson Shalini , Karlsson Cecilia , Christensen Hege , Jansson‐Löfmark Rasmus , Åsberg Anders , Robertsen Ida
Published: May 2024

This article summarizes the lessons learned from the COCKTAIL study: an open, three‐armed, single‐center study including patients with obesity scheduled for treatment with Roux‐en‐Y gastric bypass (RYGB) or nonsurgical calorie restriction, and a normal‐ to overweight control group. The clinical implications of the results from multiple peer‐reviewed articles describing the effects of RYGB, severe caloric restriction, weight loss, and type 2 diabetes on the in vivo activity and protein expression of drug‐metabolizing enzymes (cytochrome P450 (CYP) 1A2, 2C9, 2C19, and 3A) and transporters (DMETs; organic anion‐transporting polypeptide (OATP) 1B1 and P‐glycoprotein (P‐gp)) are discussed in the perspective of three clinically relevant questions: (1) How should clinicians get the dose right in patients after RYGB? (2) Will drug disposition in patients with obesity be normalized after successful weight loss? (3) Are dose adjustments needed according to obesity and diabetes status? Overall, RYGB seems to have a lower impact on drug disposition than previously assumed, but clinicians should pay close attention to drugs with a narrow therapeutic range or where a high maximum drug concentration may be problematic. Whether obesity‐related alterations of DMETs normalize with substantial weight loss depends on the DMET in question. Obesity and diabetes downregulate the in vivo activity of CYP2C19 and CYP3A (only obesity) but whether substrate drugs should be dose adjusted is also dependent on other factors that influence clearance, that is, liver blood flow and protein binding. Finally, we recommend frequent and individualized follow‐up due to high inter‐ and intraindividual variability in these patients, particularly following RYGB.
A fixed‐frequency second‐order generalized integrator phase‐locked loop‐based phase synchronization control in multisegment wireless power transfer systems
Authors: Wang Jintao , Shi Zhuoqun , Sun Qianfang , Guo Yanhua , Hou Yanjin , Liu Zhizhen
Published: May 2024

Multisegment wireless power transfer (MSWPT) technology provides a solution to the challenges of dust‐free environments and automation faced by automated material handling systems (AMHS) in current semiconductor wafer factories. However, variations in track current frequency and phase offset on the transmitting side of the MSWPT technology may lead to significant deficits in energy transmission capability. This paper introduces a method based on the fixed‐frequency second‐order generalized integrator phase‐locked loop (FFSOGI‐PLL) structure for frequency and phase synchronization among multiple transmitters in a MSWPT system. By synchronizing the track currents of multiple transmitters, this method significantly enhances the energy harvesting capacity of the H‐type pickup in the overhead hoist transport (OHT) system, ensuring stable voltage at the receiver (Rx) load. Both theoretical simulations and experiments confirm that the proposed method can effectively capture the phase difference of track current and achieve frequency locking and phase tracking. Building on this theoretical foundation, we constructed three transmitter (Tx) systems and a 1.5 kW Rx equipped with an H‐type pickup. This setup is capable of real‐time monitoring and phase‐synchronization control of track currents with varying phase offsets. The results convincingly demonstrate the strong performance and stability of the proposed method.
Kinetic theory of weakly ionized plasma and electrolyte mixtures including Onsager matrix and frequency dispersion effects
Authors: Ebeling W.
Published: May 2024

We summarize the method of hydrodynamic approximation for weakly ionized plasmas developed with Klimontovich in 1962 and give a generalization to many—component systems using Onsagers matrix theory and including dispersion effects. We develop the conductivity theory of complex plasma and electrolyte mixtures based on the model of charged hard spheres with given non‐additive contact distances, including frequency‐dependent electric fields. These generalizations are made with the aim to allow applications to complex natural systems as atmospheric plasmas and seawater. Finally, we give as an example a numerical calculation of the single ion conductivities of a six‐component seawater model.
Multiband multiple‐input multiple‐output antenna design with high‐resolution circularly polarized wireless communication
Authors: Dhanalakshmi K. M. , Kavya G.
Published: May 2024

A design problem of multiband multi‐input, multi‐output (MIMO) antenna arrays for maximal side lobe level lessening with constraint of a fixed beam width is dealt with. Multiband MIMO antenna is the most promising solution in a communication system, due to its maximal speed, higher data rate, and short‐range communication. Conversely, MIMO faces several complications including designing a proper antenna for a specific bandwidth and lesser antenna efficacy. In this manuscript, a high‐resolution CP multiband MIMO (HS‐CPMB‐MIMO) antenna design for wireless communication is proposed. MIMO antenna plays a vital part in the present wireless technology at MSA. A multiband microstrip line‐fed two‐port hybrid CPMIMO antenna is intended and fabricated. The proposed microstrip feed antenna contains a tapering structure, and the inverted L‐shaped slots in the radiating element are opened on both sides to present notches in sub‐6‐GHz frequencies. The inverted L‐shaped slots is positioned in the middle of asymmetric Z‐shaped radiating elements for enhancing the isolation among the two ports. The invention of a multiband MIMO antenna with four CP bands has an efficient ECC value because of a large L‐shaped slot in the ground as well as a protruding Z‐shape ground stub embedded with circular rings to have highly isolated cells. Finally, the proposed HS‐CPMB‐MIMO antenna design is implemented by utilizing simulation software CST Microwave Studio, and it is evaluated with the performance metrics. The simulation outcomes of the proposed HS‐CPMB‐MIMO antenna provide 36.34%, 57.36%, and 25.33% higher BW, 24.13%, 15.96%, and 21.22% higher gain compared with existing methods.
Invasive freshwater snails are less sensitive to population density than native conspecifics
Authors: Lewis Najev Briante Shevon , Neiman Maurine
Published: May 2024

Understanding how and why some species or lineages become invasive is critically important for effectively predicting and mitigating biological invasions. Here, we address an important unanswered question in invasion biology: do key life‐history traits of invasive versus native lineages within a species differ in response to key environmental stressors? We focus on the environmental factor of population density, which is a fundamental characteristic of all populations, and investigate how changes in density affect native versus invasive Potamopyrgus antipodarum (New Zealand mudsnail). P. antipodarum has invaded 39 countries and detrimentally affects invaded environments. Previous studies of native and invasive populations and from laboratory experiments have demonstrated that growth and reproduction of P. antipodarum is sensitive to population density, though whether and how this sensitivity varies across native versus invasive lineages remains uncharacterized. We quantified individual growth rate and reproduction in P. antipodarum from multiple distinct native and invasive lineages across three different population density treatments. The growth of native but not invasive lineages decreased as density increased. There was no differential effect of density treatment on embryo production of invasive versus native snails, but a significantly higher proportion of snails were reproductive in high density compared to intermediate density for invasive lineages. In native lineages, there were no significant differences in the relative frequency of reproductive snails across density treatments. While the extent to which these results from our laboratory study can be extrapolated to the more complex natural world remain unclear, our findings are consistent with a scenario where differential sensitivity to population density could help explain why some lineages become successful invaders. Our findings also align with previous studies that show that invasive P. antipodarum lineages exhibit a relatively wide range of tolerance to environmental stressors.
Updated range map of an endangered salamander and congeneric competitor reveals different niche preferences
Authors: Werba Jo A. , Miller David A. W. , Brand Adrianne B. , Grant Evan H. Campbell
Published: May 2024

Estimating distributions for cryptic and highly range‐restricted species induces unique challenges for species distribution modeling. In particular, bioclimatic covariates that are typically used to model species ranges at regional and continental scales may not show strong variation at scales of 100s and 10s of meters. This limits both the likelihood and usefulness of correlated occurrence to data typically used in distribution models. Here, we present analyses of species distributions, at 100 × 100 m resolution, for a highly range restricted salamander species (Shenandoah salamander, Plethodon shenandoah) and a closely related congener (red‐backed salamander, Plethodon cinereus). We combined data across multiple survey types, account for seasonal variation in availability of our target species, and control for repeated surveys at locations– all typical challenges in range‐scale monitoring datasets. We fit distribution models using generalized additive models that account for spatial covariates as well as unexplained spatial variation and spatial uncertainty. Our model accommodates different survey protocols using offsets and incorporates temporal variation in detection and availability resulting from survey‐specific variation in temperature and precipitation. Our spatial random effect was crucial in identifying small‐scale differences in the occurrence of each species and provides cell‐specific estimates of uncertainty in the density of salamanders across the range. Counts of both species were seen to increase in the 3 days following a precipitation event. However, P. cinereus were observed even in extremely wet conditions, while surface activity of P. shenandoah was associated with a more narrow range. Our results demonstrate how a flexible analytical approach improves estimates of both distribution and uncertainty, and identify key abiotic relationships, even at small spatial scales and when scales of empirical data are mismatched. While our approach is especially valuable for species with small ranges, controlling for spatial autocorrelation, estimating spatial uncertainty, and incorporating survey‐specific information in estimates can improve the reliability of distribution models in general.
Heterogeneity in breeding productivity is driven largely by factors affecting nestlings and young fledglings in an imperiled migratory passerine
Authors: McNeil Darin J. , Rodewald Amanda D. , Ruiz‐Gutierrez Viviana , Fiss Cameron J. , Larkin Jeffery L.
Published: May 2024

Identifying factors that drive variation in vital rates among populations is a prerequisite to understanding a species' population biology and, ultimately, to developing effective conservation strategies. This is especially true for imperiled species like the golden‐winged warbler (Vermivora chrysoptera) that exhibit strong spatial heterogeneity in demography and responds variably to conservation interventions. Habitat management actions recommended for breeding grounds conservation include timber harvest, shrub shearing, and prescribed fire that maintain or create early successional woody communities. Herein, we assessed variation in the survival of nests [n = 145] and fledglings [n = 134] at 17 regenerating timber harvest sites within two isolated populations in Pennsylvania that differed in productivity and response to habitat management. Although the overall survival of nests and fledglings was higher in the eastern population than the central population, this was only true when the nest phases and fledgling phases were considered wholly. Indeed, survival rates of nestlings and recently fledged young (1–5 days post‐fledging) were lower in the central population, whereas eggs and older fledglings (6–30 days post‐fledging) survived at comparable rates in both populations. Fledglings in the central population were smaller (10% lower weight) and begged twice as much as those in the eastern population, suggesting food limitation may contribute to lower survival rates. Fledgling survival in the central population, but not the eastern, also was a function of habitat features (understory vegetation density [positive] and distance to mature forest [negative]) and individual factors (begging effort [negative]). Our findings illustrate how identifying how survival varies across specific life stages can elucidate potential underlying demographic drivers, such as food resources in this case. In this way, our work underscores the importance of studying and decomposing stage‐specific demography in species of conservation concern.
Synergistic Optimization of Europium‐Doped Yttria for Photoluminescence and Triboelectric Nanogenerator Applications
Authors: Zawar Daksha , Mishra Siju , Rakshita Muddamalla , Pradhan Payal P. , Durga Prasad Kasireddi A. K. , Potu Supraja , Madathil Navaneeth , Pani Jitesh , Kishore Babu Nagumothu , Borkar Hitesh , Rajaboina Rakesh Kumar , Haranath Divi
Published: May 2024

In recent years, multifunctional applications of the same material have gained wide recognition in various fields. The present study reports the synthesis, characterization, and multifunctional applications of europium (Eu)‐doped yttrium oxide (Y2O3) nanophosphor. Synergistic optimization of Eu‐doped Y2O3 results in enhanced photoluminescence (PL) and triboelectric nanogenerator (TENG) performance. Eu‐doped Y2O3 nanophosphors are synthesized using an autocombustion method, and comprehensive characterizations are conducted. The investigations indicate that the Eu doping significantly influences the PL intensity, with the highest emission observed at 3 mol% for powders. The synthesized nanophosphors are blended with silicone to fabricate hybrid films, which are utilized for energy harvesting applications using TENG technology. The TENG devices fabricated with these hybrid films demonstrate a notable relationship between the Eu concentration and the electrical output, achieving peak performance at 1 mol% Eu doping. The maximum output voltage of ≈535 V, short‐circuit current of ≈38 μA, and power density of 800 mW m−2 are observed. Further, TENG is demonstrated in a self‐powered UV photodetector application. The present results contribute to the improvement of sustainable energy technologies and open up a new window for multifunctional materials.