bluuebunny/crossref_metadata_2025 huggingface dataset:
Cultural adaptation of the Integrated Palliative care Outcome Scale for neurological symptoms
Authors: Dillen Kim , Goereci Yasemin , Dunkl Veronika , Müller Anne , Fink Gereon R. , Voltz Raymond , Hocaoglu Mevhibe , Warnke Clemens , Golla Heidrun
Published: April 2023

Objectives

Standardized measures for assessing neurological patients needing palliative care remain scarce. The Integrated Palliative care Outcome Scale for neurological patients in its short form (IPOS Neuro-S8) helps assess and identify patients’ symptom burden and needs early but has not yet been validated in German. The aim was to culturally adapt and translate the IPOS Neuro-S8 into the German health-care context and evaluate its face and content validity.

Methods

Cultural adaptation study following the first 6 out of 8 phases of the Palliative care Outcome Scale measures manual: (1) conceptual definition, (2) forward translation to German, (3) backward translation to English, (4) expert review, (5) cognitive debriefing, (6) proofreading. Neurological patients needing palliative care and clinical staff of the Department of Palliative Medicine or Neurology of the University Hospital of Cologne were included. Data were analyzed using thematic content analysis and descriptive statistics.

Results

A total of 13 patients and 16 clinical staff participated in this study. The expert review panel (phase 4) consisted of 11 additional members. While patients (n = 9) and clinical staff (n = 11) confirmed that the IPOS Neuro-S8 is an intelligible tool that is well accepted (phase 5), some linguistic and cultural differences were found between the original English and German versions. These mainly concerned the items mouth problems and spasms.

Significance of results

The German version of the IPOS Neuro-S8 has demonstrated face and content validity and captures relevant symptoms of neurological patients needing palliative care. Its psychometric properties, including construct and criterion validity, will be investigated next.
Conceptualizing responsibility in world politics
Authors: Sienknecht Mitja , Vetterlein Antje
Published: April 2023

Moral responsibility is a prominent concept used in political discourses and theoretical debates. Yet disagreement remains on how it could work in practice. When attempting to address global challenges such as global poverty, combating atrocities, or artificial intelligence, approaches often revert to retrospective accounts of responsibility that focus on non-compliance with regulatory frameworks. As a result, cases where prospective responsibility would be required often go unaddressed. In this article, we introduce an analytical conceptualization of responsibility that should help to guide the application of moral responsibility in such situations. In the first step, we develop a typology that distinguishes between four types of responsibility: ‘obligatory’, ‘structural’, ‘prescribed’, and ‘discursive’. Second, we identify responsibility gaps for each responsibility type. Third, we introduce different ethical principles from political theory that help to identify potential responsibility relations. We illustrate the utility of this framework with the example of climate change, where ethical principles beyond the contribution principle have already been applied. The paper facilitates new perspectives in political debates about how to allocate responsibility in light of global challenges and enhances theoretical debates in International Relations scholarship.
“Ministering at the Altar of Slavery”: Religious slavery conflict and social movement repression
Authors: George Kristin
Published: April 2023

Why did some American Protestant denominations experience slavery-related schism during the nineteenth century, while others appear to have been unaffected by slavery conflict? I conduct a comparative case study of four national Protestant denominations and find that slavery-related schism was not a consequence of a particular theological orientation, but instead occurred when denominational leaders lacked the capacity to repress abolitionism. In all four denominations, leaders attempted to stifle the abolition movement to avoid conflict. Their capacities to do so differed, however: in some denominations, diffusely distributed authority created openings for abolitionist mobilization, eventually leading to irreconcilable conflict and schism. In other denominations, concentrated authority enabled repression, leaders blocked abolitionist mobilization, and schism was avoided. This research shows that non-state targets of social movements can use “soft” forms of repression to undermine movement mobilization, but that their capacity to do so is constrained by organizational characteristics. It also demonstrates the critical role of organizational dynamics in shaping religious responses to contentious issues more broadly.
work & care - Der Weg zur Vereinbarkeitskompetenz
Authors: Bischofberger Iren
Published: April 2023

Im Zentrum des Buches stehen Personen, die neben ihrer Erwerbstätigkeit auch Sorgeverantwortung tragen für kranke, beeinträchtigte oder hochaltrige Angehörige - also „work & care“. Dieses Thema gewinnt immer mehr an Aufmerksamkeit, denn es steht im Schnittfeld zweier knapper Ressourcen - des privaten unbezahlten Sorgepotenzials für Nahestehende einerseits und des Erwerbspotenzials andererseits. 
Das thematische Feld wird systematisch aufgearbeitet - sowohl begrifflich-theoretisch, als auch analytisch und unter Einbezug der internationalen Forschung. Auf dieser Wissensgrundlage fragen die AutorInnen systematisch danach, welche fachlichen, disziplinären und politischen Konsequenzen daraus erwachsen - für die Pflegewissenschaft im Speziellen und für die gesundheitspolitischen Reformen im Allgemeinen. Aus diesen intensiv verfolgten Spuren ergebensich Konturen einer breit hergeleiteten personalen und organisationalen Vereinbarkeitskompetenz. 
Das Buch fördert die überfällige Weiterentwicklung der Pflegewissenschaft v.a. im deutschsprachigen Raum, die nicht im bisherigen Torso von Forschung, Hochschulbildung, Pflegemanagement und klinischer Praxis stehen bleiben darf, sondern auch die Bühne der wissenschaftlichen Politikberatung bespielen muss. Denn hier ist Meinungsbildung im Dialog mit Behörden und Politik sowohl für die Pflegewissenschaft als auch die Orchestrierung von „work & care“ angezeigt.
Spatial Heterogeneity of Vegetation Resilience Changes to Different Drought Types
Authors: Zhang Yu , Liu Xiaohong , Jiao Wenzhe , Wu Xiuchen , Zeng Xiaomin , Zhao Liangju , Wang Lixin , Guo Jiaqi , Xing Xiaoyu , Hong Yixue
Published: April 2023

Resilience is a fundamental concept for vegetation health. The increasing drought frequency and severity may pose severe threat to vegetation resilience. However, it is still not clear how vegetation resilience is evolving in response to climate change in pivotal biographical zones. Here, we examined the resilience changes in terms of leaf area index (LAI, an indicator of canopy structure) and gross primary productivity (GPP, an indicator of carbon uptake) in responding to the Standardized Precipitation‐Evapotranspiration Index (SPEI) and vapor pressure deficit (VPD) over China's Loess Plateau and Qinling Mountains. Linking remote sensing variables and tree ring width allows the upscaling of plot‐based vegetation growth information. We further explored potential explanatory factors associated with the heterogeneous spatial distributions of resilience changes. Results revealed that the resilience of GPP weakened more than LAI in response to drought, suggesting that compared to LAI, productivity requires more time to recover to the pre‐drought levels. Regionally, the change of vegetation resilience on the Loess Plateau and in high‐altitude areas was highly susceptible to SPEI and VPD, respectively. The observed spatial heterogeneity in resilience changes was mainly attributed by climate zone, water deficit, and their interactions. Our findings provide direct and empirical evidence that the vegetation in the Loess Plateau and Qinling Mountains is gradually losing resilience. The results indicate that sustained ecosystem water deficit and atmospheric dryness will continue to threaten vegetation survival and terrestrial ecosystem service.
Extracting Exospheric Temperature From Daytime Ionospheric Electron Density Profiles
Authors: Li Shaoyang , Ren Zhipeng , Yue Xinan , Liu Libo , Yu Tingting , Wei Yong
Published: April 2023

Given that the ionosphere is strongly determined by the thermosphere and its state depends on thermospheric parameters, we propose a new method to extract exospheric temperature (Tex) from electron density (Ne) profiles based on the relationship between the variations in Tex and Ne profiles established through simulation. Ne profiles and corresponding Tex from the Millstone Hill incoherent scatter radar (ISR) observations are used to test the method. ISR Ne profiles are used for Tex retrieval and ISR Tex is used to make a comparison with Tex calculated by model and retrieved Tex. The results show that the retrieved Tex effectively captures diurnal, anomalous and short‐period variations. The relative deviation between the retrieved–observed Tex is approximately 2%, which is significantly improved compared with the Mass Spectrometer Incoherent Scatter model, especially under disturbed conditions. This result confirms that thermospheric temperature variation can be deduced from ionospheric profiles and our method can be considered a useful tool to obtain Tex from Ne profiles.
Redox‐Independent Low Water Solubility in Quartz and Implications for Water Storage in the Crust
Authors: Zhang Kai , Yang Tao , Yang Xiaozhi
Published: April 2023

Quartz is an important mineral constituent of the continental crust, which commonly contains trace amounts of water as hydroxyl in the lattice. Despite considerable efforts to document the roles of pressure, temperature, and chemistry on water storage in quartz, the effect of redox state, a key thermodynamic factor in Earth sciences, has not been well established. We assessed the redox effect on water solubility in quartz at 2 and 10 kbar and 800°C, by equilibrating two natural gem‐quality crystals with water over a range of redox conditions. Recovered samples show infrared absorption bands at 3,100–3,600 cm−1. Dehydration experiments at 1200°C (room pressure) suggest that the two bands at ∼3,197 and 3,293 cm−1 are linked to Si‐O overtones, with the other bands to hydroxyl. The water solubility, ∼3.7–32.2 ppm wt. H2O, is redox‐independent, differing from other minerals such as feldspar, pyroxenes, garnet, rutile, and olivine in which the water solubility is significantly redox‐dependent. This provides evidence that the water incorporation in quartz is not controlled by polyvalent elements and/or other redox‐linked mechanisms. Considering the roles of Al, Li, and B in incorporating water and its low solubility over remarkable variations in the abundances of those elements in most natural samples, quartz is not a major water carrier compared to other nominally anhydrous minerals (NAMs) in the crust. The partitioning of water between quartz and other crustal NAMs such as feldspar, pyroxenes, rutile, and garnet is redox‐influenced, and is unlikely to be constant in the crust.
Nonlinear Growth and Physiological Responses of White Spruce at North American Arctic Treeline
Authors: Lévesque Mathieu , Andreu‐Hayles Laia , D’Arrigo Rosanne , Oelkers Rose , Buckley Brendan M.
Published: April 2023

Much is still unknown about the growth and physiological responses of trees to global change at the northern treeline. We combined tree‐ring width data with century‐long stable carbon and oxygen isotope records to investigate growth and physiological responses of white spruce at two treeline sites in the Canadian Arctic to concurrent increases in temperature, atmospheric CO2concentration (ca), and decline in sea ice extent over the past century. The tree‐ring records were assessed during three periods with contrasting climatic conditions: (a) the early 20th century warming, (b) the 1940–1970 cooling period, and (c) the anthropogenic late 20th century warming period. We found opposing growth trends between the two sites, but similar carbon isotope discrimination (Δ13C) and intrinsic water‐use efficiency (iWUE) trajectories. While tree growth (defined as basal area increment) increased at the site nearer to the Arctic Ocean during the 20th century following the rise in temperature and sea ice loss, growth declined after 1950 at the more interior site. At both sites, Δ13C slightly increased over these periods. However, trees showed a nonlinear response to increasedca, shifting after 1970 from a passive stomatal response (i.e., no changes iniWUE) to an active response (i.e., a moderate ∼12% increase iniWUE). Further, our isotope‐based findings do not support the idea that temperature‐induced drought stress caused the divergent growth trends at our treeline sites. This study thus highlights nonlinear and complex physiological and growth adjustments to concomitant changes in temperature, sea ice extent, andcaover the last century at the northern treeline.
The synaptic hypothesis of schizophrenia version III: a master mechanism
Authors: Howes Oliver D. , Onwordi Ellis Chika
Published: April 2023

The synaptic hypothesis of schizophrenia has been highly influential. However, new approaches mean there has been a step-change in the evidence available, and some tenets of earlier versions are not supported by recent findings. Here, we review normal synaptic development and evidence from structural and functional imaging and post-mortem studies that this is abnormal in people at risk and with schizophrenia. We then consider the mechanism that could underlie synaptic changes and update the hypothesis. Genome-wide association studies have identified a number of schizophrenia risk variants converging on pathways regulating synaptic elimination, formation and plasticity, including complement factors and microglial-mediated synaptic pruning. Induced pluripotent stem cell studies have demonstrated that patient-derived neurons show pre- and post-synaptic deficits, synaptic signalling alterations, and elevated, complement-dependent elimination of synaptic structures compared to control-derived lines. Preclinical data show that environmental risk factors linked to schizophrenia, such as stress and immune activation, can lead to synapse loss. Longitudinal MRI studies in patients, including in the prodrome, show divergent trajectories in grey matter volume and cortical thickness compared to controls, and PET imaging shows in vivo evidence for lower synaptic density in patients with schizophrenia. Based on this evidence, we propose version III of the synaptic hypothesis. This is a multi-hit model, whereby genetic and/or environmental risk factors render synapses vulnerable to excessive glia-mediated elimination triggered by stress during later neurodevelopment. We propose the loss of synapses disrupts pyramidal neuron function in the cortex to contribute to negative and cognitive symptoms and disinhibits projections to mesostriatal regions to contribute to dopamine overactivity and psychosis. It accounts for the typical onset of schizophrenia in adolescence/early adulthood, its major risk factors, and symptoms, and identifies potential synaptic, microglial and immune targets for treatment.
Thermophilic Dehalococcoidia with unusual traits shed light on an unexpected past
Authors: Palmer Marike , Covington Jonathan K , Zhou En-Min , Thomas Scott C , Habib Neeli , Seymour Cale O , Lai Dengxun , Johnston Juliet , Hashimi Ameena , Jiao Jian-Yu , Muok Alise R , Liu Lan , Xian Wen-Dong , Zhi Xiao-Yang , Li Meng-Meng , Silva Leslie P , Bowen Benjamin P , Louie Katherine , Briegel Ariane , Pett-Ridge Jennifer , Weber Peter K , Tocheva Elitza I , Woyke Tanja , Northen Trent R , Mayali Xavier , Li Wen-Jun , Hedlund Brian P
Published: April 2023

Although the phylum Chloroflexota is ubiquitous, its biology and evolution are poorly understood due to limited cultivability. Here, we isolated two motile, thermophilic bacteria from hot spring sediments belonging to the genus Tepidiforma and class Dehalococcoidia within the phylum Chloroflexota. A combination of cryo-electron tomography, exometabolomics, and cultivation experiments using stable isotopes of carbon revealed three unusual traits: flagellar motility, a peptidoglycan-containing cell envelope, and heterotrophic activity on aromatics and plant-associated compounds. Outside of this genus, flagellar motility has not been observed in Chloroflexota, and peptidoglycan-containing cell envelopes have not been described in Dehalococcoidia. Although these traits are unusual among cultivated Chloroflexota and Dehalococcoidia, ancestral character state reconstructions showed flagellar motility and peptidoglycan-containing cell envelopes were ancestral within the Dehalococcoidia, and subsequently lost prior to a major adaptive radiation of Dehalococcoidia into marine environments. However, despite the predominantly vertical evolutionary histories of flagellar motility and peptidoglycan biosynthesis, the evolution of enzymes for degradation of aromatics and plant-associated compounds was predominantly horizontal and complex. Together, the presence of these unusual traits in Dehalococcoidia and their evolutionary histories raise new questions about the timing and selective forces driving their successful niche expansion into global oceans.
Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials
Authors: Girithar Hemaasri-Neya , Staats Pires Ananda , Ahn Seong Beom , Guillemin Gilles J. , Gluch Laurence , Heng Benjamin
Published: April 2023

Breast cancer (BrCa) is the leading cause of cancer incidence and mortality in women worldwide. While BrCa treatment has been shown to be highly successful if detected at an early stage, there are few effective strategies to treat metastatic tumours. Hence, metastasis remains the main cause in most of BrCa deaths, highlighting the need for new approaches in this group of patients. Immunotherapy has been gaining attention as a new treatment for BrCa metastasis and the kynurenine pathway (KP) has been suggested as one of the potential targets. The KP is the major biochemical pathway in tryptophan (TRP) metabolism, catabolising TRP to nicotinamide adenine dinucleotide (NAD+). The KP has been reported to be elevated under inflammatory conditions such as cancers and that its activity suppresses immune surveillance. Dysregulation of the KP has previously been reported implicated in BrCa. This review aims to discuss and provide an update on the current mechanisms involved in KP-mediated immune suppression and cancer growth. Furthermore, we also provide a summary on 58 studies about the involvement of the KP and BrCa and five clinical trials targeting KP enzymes and their outcome.
Learning naturalistic driving environment with statistical realism
Authors: Yan Xintao , Zou Zhengxia , Feng Shuo , Zhu Haojie , Sun Haowei , Liu Henry X.
Published: April 2023

For simulation to be an effective tool for the development and testing of autonomous vehicles, the simulator must be able to produce realistic safety-critical scenarios with distribution-level accuracy. However, due to the high dimensionality of real-world driving environments and the rarity of long-tail safety-critical events, how to achieve statistical realism in simulation is a long-standing problem. In this paper, we develop NeuralNDE, a deep learning-based framework to learn multi-agent interaction behavior from vehicle trajectory data, and propose a conflict critic model and a safety mapping network to refine the generation process of safety-critical events, following real-world occurring frequencies and patterns. The results show that NeuralNDE can achieve both accurate safety-critical driving statistics (e.g., crash rate/type/severity and near-miss statistics, etc.) and normal driving statistics (e.g., vehicle speed/distance/yielding behavior distributions, etc.), as demonstrated in the simulation of urban driving environments. To the best of our knowledge, this is the first time that a simulation model can reproduce the real-world driving environment with statistical realism, particularly for safety-critical situations.
Entanglement asymmetry as a probe of symmetry breaking
Authors: Ares Filiberto , Murciano Sara , Calabrese Pasquale
Published: April 2023

Symmetry and symmetry breaking are two pillars of modern quantum physics. Still, quantifying how much a symmetry is broken is an issue that has received little attention. In extended quantum systems, this problem is intrinsically bound to the subsystem of interest. Hence, in this work, we borrow methods from the theory of entanglement in many-body quantum systems to introduce a subsystem measure of symmetry breaking that we dub entanglement asymmetry. As a prototypical illustration, we study the entanglement asymmetry in a quantum quench of a spin chain in which an initially broken global U(1) symmetry is restored dynamically. We adapt the quasiparticle picture for entanglement evolution to the analytic determination of the entanglement asymmetry. We find, expectedly, that larger is the subsystem, slower is the restoration, but also the counterintuitive result that more the symmetry is initially broken, faster it is restored, a sort of quantum Mpemba effect, a phenomenon that we show to occur in a large variety of systems.
Carbon sequestration by multiple biological pump pathways in a coastal upwelling biome
Authors: Stukel Michael R. , Irving John P. , Kelly Thomas B. , Ohman Mark D. , Fender Christian K. , Yingling Natalia
Published: April 2023

Multiple processes transport carbon into the deep ocean as part of the biological carbon pump, leading to long-term carbon sequestration. However, our ability to predict future changes in these processes is hampered by the absence of studies that have simultaneously quantified all carbon pump pathways. Here, we quantify carbon export and sequestration in the California Current Ecosystem resulting from (1) sinking particles, (2) active transport by diel vertical migration, and (3) the physical pump (subduction + vertical mixing of particles). We find that sinking particles are the most important and export 9.0 mmol C m−2 d−1 across 100-m depth while sequestering 3.9 Pg C. The physical pump exports more carbon from the shallow ocean than active transport (3.8 vs. 2.9 mmol C m−2 d−1), although active transport sequesters more carbon (1.0 vs. 0.8 Pg C) because of deeper remineralization depths. We discuss the implications of these results for understanding biological carbon pump responses to climate change.
Hidden vulnerability of US Atlantic coast to sea-level rise due to vertical land motion
Authors: Ohenhen Leonard O. , Shirzaei Manoochehr , Ojha Chandrakanta , Kirwan Matthew L.
Published: April 2023

The vulnerability of coastal environments to sea-level rise varies spatially, particularly due to local land subsidence. However, high-resolution observations and models of coastal subsidence are scarce, hindering an accurate vulnerability assessment. We use satellite data from 2007 to 2020 to create high-resolution map of subsidence rate at mm-level accuracy for different land covers along the ~3,500 km long US Atlantic coast. Here, we show that subsidence rate exceeding 3 mm per year affects most coastal areas, including wetlands, forests, agricultural areas, and developed regions. Coastal marshes represent the dominant land cover type along the US Atlantic coast and are particularly vulnerable to subsidence. We estimate that 58 to 100% of coastal marshes are losing elevation relative to sea level and show that previous studies substantially underestimate marsh vulnerability by not fully accounting for subsidence.
Association between smoking and all-cause mortality in Parkinson’s disease
Authors: Yoon Seo Yeon , Park You Hyun , Lee Sang Chul , Suh Jee Hyun , Yang Seung Nam , Kang Dae Ryong , Kim Yong Wook
Published: April 2023

We aimed to investigate the association between smoking status and all-cause mortality of Parkinson’s disease (PD). Among the whole nationwide population data from Korea National Health Insurance Service, newly diagnosed PD was selected, and all-cause mortality was evaluated. The systematic review was performed through a literature search on the PubMed, EMBASE, and Cochrane Central Register of Controlled Trials databases. Among 26,080 individuals with PD, there was no significant association between smoking status and all-cause mortality in a nationwide cohort study (ex-smoker, HR 0.1.03, 95% CI 0.97–1.10; current smoker, HR 1.06, 95% CI 0.96–1.16). The systematic review, including six prospective cohort studies, also found a nonsignificant association. PD smokers tended to have fewer deaths from neurologic causes but were significantly more likely to die from smoking-related cancers such as lung cancer. We presented a nonsignificant association between smoking and mortality of PD, and cigarette smoking is not recommended in individuals with PD.
High protein-containing new food by cell powder meat
Authors: Choi Bumgyu , Park Sohyeon , Lee Milae , Jung Sungwon , Lee Hyun , Bang Geul , Kim Jiyu , Hwang Heeyoun , Yoo Ki Hyun , Han Dongoh , Lee Seung Tae , Koh Won-Gun , Hong Jinkee
Published: April 2023

Demand for a new protein source to replace meat is increasing to solve various issues such as limited resources and food shortages. Diverse protein sources are being developed, but alternative proteins such as plants or insects need to improve people’s perceptions and organoleptic properties. Therefore, cell-based meat research is intensively conducted, and most studies are aimed at scale-up and cost-down via the research of scaffolds and culture media. Here, we proposed a new food by cell powder meat (CPM), which has a high protein content and a meaty flavor. The powder was manufactured 76% more cost-effectively with less serum than the conventional culture medium and without 3D scaffold. Due to its comprehensive characteristics, the potential applicability of CPM in the cell-based meat industry could be expected.
The effect of different aqueous solutions ratios of Ocimum basilicum utilized in AgNPs synthesis on the inhibition of bacterial growth
Authors: Qaeed Motahher A. , Hendi Abdulmajeed , Obaid Ahmed S. , Thahe Asad A. , Osman Abdalghaffar M. , Ismail A. , Mindil A. , Eid Alharthi A. , Aqlan Faisal , Osman Nadir M. A. , AL-Farga Ammar , Al-Maaqar Saleh M. , Saif Ala’eddin A.
Published: April 2023

This study examined the effect of varying concentrations of Ocimum basilicum aqueous extract, which was done via the green synthesis of Silver nanoparticles (AgNPs), on the identification of the most effective concentration for bacteria inhibitory activity. Different concentrations of the aqueous Ocimum basilicum extract (0.25, 0.50, 0.75 and 1.00 mM) were used as reducing and stabilizing agent to synthesize AgNPs by means of the reduction method. The crystal structure and morphology of the NPs were characterized UV–Vis spectra, X-ray diffraction (XRD) and scanning electron microscopy (SEM). The antibacterial efficacy of AgNPs was studied against E. coli ATCC 35218 using well diffusion, MIC, MBC, and time-kill curve. The dark yellow color of the Ocimum basilicum aqueous solution indicates the successful synthesis process of the AgNPs. UV-spectra of the AgNPs display a gradual increase of absorption in sequence with concentration increase of aqueous Ocimum basilicum extract solution from 0.25 to 1.00 mM. This, in turn, led to a shift in the wavelength from 488 to 497 nm, along with a change in the nanoparticle size from 52 to 8 nm. The tests also showed a high activity of the particles against bacteria (E. coli), ranging between 15.6 and 62.5 µg/ml. Based on AgNPs, it was confirmed that an aqueous Ocimum basilicum extract can be used as an effective, reducing and stabilizing agent for the synthesis of different sizes of AgNPs based on the solvent concentration. The AgNPs also proved to be effective in inhibiting and killing bacteria.
Cotton functionalized with polyethylene glycol and graphene oxide for dual thermoregulating and UV-protection applications
Authors: Kumar Amit , Kebaili Imen , Boukhris Imed , Vaish Rahul , Kumar Anuruddh , Park Hyeong Kwang Benno , Joo Yun Hwan , Sung Tae Hyun
Published: April 2023

A thermoregulating smart textile based on phase change material (PCM) polyethylene glycol (PEG) was prepared by chemically grafting carboxyl-terminated PEG onto cotton. Further deposits of graphene oxide (GO) nanosheets were made on the PEG grafted cotton (PEG-g-Cotton) to improve the thermal conductivity of the fabric and to block harmful UV radiation. The GO-PEG-g-Cotton was characterized by Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), Raman spectroscopy, X-ray diffraction (XRD), x-ray photoelectron spectroscopy (XPS), and field emission-scanning electron microscopy (FE-SEM). With an enthalpy of 37 and 36 J/g, respectively, the DSC data revealed that the functionalized cotton's melting and crystallization maxima occurred at 58 °C and 40 °C, respectively. The thermogravimetric analysis (TGA) presented that GO-PEG-g-Cotton was thermally more stable in comparison to pure cotton. The thermal conductivity of PEG-g-Cotton increased to 0.52 W/m K after GO deposition, while pure cotton conductivity was measured as 0.045 W/m K. The improvement in the UV protection factor (UPF) of GO-PEG-g-Cotton was observed indicating excellent UV blocking. This temperature-regulating smart cotton offers a high thermal energy storage capability, better thermal conductivity, thermal stability, and excellent UV protection.
Comparing the effectiveness of two surgical techniques for treating lower lid epiblepharon in children: a randomized controlled trial
Authors: Takeuchi Masaki , Matsumura Nozomi , Ohno Tomoko , Fujita Takeshi , Asano Mizuki , Mizuki Nobuhisa
Published: April 2023

A multicenter randomized controlled trial was conducted to compare the effectiveness of incisional and nonincisional surgical techniques for treating lower lid epiblepharon in children. The study included 89 eyes from 50 children aged 3–15 years (mean, 7.5 ± 2.4 years) with moderate lower lid epiblepharon. Patients were randomly assigned to either incisional (modified Hotz procedure with lid margin splitting; 45 eyes of 25 patients) or nonincisional (44 eyes of 25 patients) surgery groups. Treatment outcomes and changes in astigmatism were evaluated 6 months after surgery. Incisional surgery provided a significantly higher percentage (77.8%) of well-corrected treatment results (P = 0.026; odds ratio, 2.88; 95% confidence interval, 1.07–8.22) than nonincisional surgery (55.4%). The mean change in astigmatism 6 months after surgery was − 0.24 ± 0.42 and − 0.01 ± 0.47 D in the incisional and nonincisional surgery groups, respectively. The improvement in astigmatism was significantly higher in the incisional surgery group than in the nonincisional surgery group (P = 0.008). The incisional surgical treatment for moderate epiblepharon in children resulted in a higher number of well-corrected patients, indicating an absence of both ciliary touch and superficial keratitis as well as statistically significant improvements in astigmatism correction.
A new silesaurid from Carnian beds of Brazil fills a gap in the radiation of avian line archosaurs
Authors: Müller Rodrigo T. , Garcia Maurício S.
Published: April 2023

Comprising the oldest unequivocal dinosauromorphs in the fossil record, silesaurs play an important role in the Triassic radiation of dinosaurs. These reptiles provide the main source of information regarding the ancestral body plan of dinosaurs, as well as the basis for biogeographic models. Nevertheless, the co-occurrence of silesaurs and the oldest unequivocal dinosaurs is rare, which hampers reliable ecological inferences. Here we present the first species of silesaur from the oldest unequivocal dinosaur-bearing beds from Brazil. Amanasaurus nesbitti gen. et sp. nov. possesses a unique set of femoral traits among silesaurs, including the oldest occurrence of an anterior trochanter separated by the femoral shaft by a marked cleft. Its femoral length indicates that the new species rivals in size with most coeval dinosaurs. This find challenges the assumption that in faunas where silesaurs and unambiguous dinosaurs co-occurred, silesaurs were relatively smaller. Moreover, the presence of dinosaur-sized silesaurs within ecosystems with lagerpetids, sauropodomorphs and herrerasaurids reinforces the complex scenario regarding the early radiation of Pan-Aves. Silesaurs—independent of their phylogenetic position—persisted during most of the Triassic Period, with its plesiomorphic body size advancing through the dawn of dinosaurs, instead of silesaur lineages decrease in body size through time.
A comprehensive toxicological analysis of trans-fatty acids (TFAs) reveals a pro-apoptotic action specific to industrial TFAs counteracted by polyunsaturated FAs
Authors: Hirata Yusuke , Kashiwabara Naoki , Nada Yuki , Inoue Aya , Sato Emiko , Noguchi Takuya , Matsuzawa Atsushi
Published: April 2023

trans-Fatty acids (TFAs) are unsaturated fatty acids containing at least one carbon–carbon double bond in trans configuration, which are classified into two groups according to their food source: industrial TFAs (iTFAs) and ruminant TFAs (rTFAs). Previous epidemiological evidence has demonstrated a preferential association of iTFAs, rather than rTFAs, with various diseases including cardiovascular diseases. However, it is still unknown how iTFAs exert their specific toxicity and what effective treatments are available to mitigate their toxicity. Here, we performed a comprehensive toxicological assessment of TFAs based on the toxicity mechanism that we established previously. We found that iTFAs including elaidic acid (EA), but not other types of fatty acids including rTFAs, had a strong pro-apoptotic effect upon treatment of extracellular ATP, a damage-associated molecular pattern that induces apoptosis through the apoptosis signal-regulating kinase 1 (ASK1)-p38 MAP kinase pathway. We also found that polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA), potently suppressed EA-dependent increase in ASK1 activation and apoptosis. These results demonstrate that iTFAs specifically exert toxicity by targeting ASK1, and that PUFAs serve as their effective suppressor. Our study provides a molecular basis for risk assessment of foods, and for new prevention and treatment strategies for TFA-related diseases.
The relationship between physical activity and premenstrual syndrome in senior high school students: a prospective study
Authors: Chen Zhuo , Imai Kazuhiro , Zhou Xiao
Published: April 2023

Reproductive-aged women experience somatic and affective symptoms of premenstrual syndrome (PMS) which affect their daily life and work, but there are limited tracking data on senior high school-age female students. To investigate the characteristics and incidence of PMS, and to detect the relationship between physical exercise participation and PMS in female students of senior high school. A prospective study was conducted among senior high school female students aged 14–16 years. The participant was asked to finish two questionnaires. One questionnaire collected information about demographic data and PMS symptoms which were recorded on a daily calendar named Daily Record of Severity of Problems (DRSP) per day. Another questionnaire was physical exercises participation questionnaire, collecting times of physical education (PE) class participation, exercise times, exercise type participation in morning exercise and recess exercise, times of morning exercise, times of recess exercise per week, recess exercise time, and autonomous exercise participation of students. The data were prospectively recorded for three consecutive months. Odds ratio (OR) with 95% confidence intervals (CI) was performed for results of the multivariate logistic regression analysis model. A total of 233 participants completed the prospective study, 78 (33.5%) participants experienced PMS. The incidence of the participants with mild PMS was 20.2% while moderate PMS was 11.6% and severe PMS was 1.7%. The most common somatic symptom was fatigue while the most common affective symptom was cannot concentrate. Participants with PE classes less than 2 times per week were 4.43 times (OR 4.43, 95% CI 1.18–16.6, p < 0.05) more possible to experience PMS than those with 2 times PE classes per week. PMS is a frequent phenomenon in senior high school female students. Female students with 2 times PE classes per week show a lower incidence of PMS. This study encouraged senior high school-age females to take more physical exercises per week and could be helpful to create a no-pharmacology coping strategy.
Plants exposed to titanium dioxide nanoparticles acquired contrasting photosynthetic and morphological strategies depending on the growing light intensity: a case study in radish
Authors: Vatankhah Akram , Aliniaeifard Sasan , Moosavi-Nezhad Moein , Abdi Sahar , Mokhtarpour Zakieh , Reezi Saeed , Tsaniklidis Georgios , Fanourakis Dimitrios
Published: April 2023

Due to the photocatalytic property of titanium dioxide (TiO2), its application may be dependent on the growing light environment. In this study, radish plants were cultivated under four light intensities (75, 150, 300, and 600 μmol m−2 s−1 photosynthetic photon flux density, PPFD), and were weekly sprayed (three times in total) with TiO2 nanoparticles at different concentrations (0, 50, and 100 μmol L−1). Based on the obtained results, plants used two contrasting strategies depending on the growing PPFD. In the first strategy, as a result of exposure to high PPFD, plants limited their leaf area and send the biomass towards the underground parts to limit light-absorbing surface area, which was confirmed by thicker leaves (lower specific leaf area). TiO2 further improved the allocation of biomass to the underground parts when plants were exposed to higher PPFDs. In the second strategy, plants dissipated the absorbed light energy into the heat (NPQ) to protect the photosynthetic apparatus from high energy input due to carbohydrate and carotenoid accumulation as a result of exposure to higher PPFDs or TiO2 concentrations. TiO2 nanoparticle application up-regulated photosynthetic functionality under low, while down-regulated it under high PPFD. The best light use efficiency was noted at 300 m−2 s−1 PPFD, while TiO2 nanoparticle spray stimulated light use efficiency at 75 m−2 s−1 PPFD. In conclusion, TiO2 nanoparticle spray promotes plant growth and productivity, and this response is magnified as cultivation light intensity becomes limited.
Effects of biochar-based materials on nickel adsorption and bioavailability in soil
Authors: Gao Weichun , He Wei , Zhang Jun , Chen Yifei , Zhang Zhaoxin , Yang Yuxiao , He Zhenjia
Published: April 2023

The potential for toxic elements to contaminate soil has been extensively studied. Therefore, the development of cost-effective methods and materials to prevent toxic element residues in the soil from entering the food chain is of great significance. Industrial and agricultural wastes such as wood vinegar (WV), sodium humate (NaHA) and biochar (BC) were used as raw materials in this study. HA was obtained by acidizing NaHA with WV and then loaded onto BC, which successfully prepared a highly efficient modification agent for nickel-contaminated soil, namely biochar-humic acid material (BC-HA). The characteristics and parameters of BC-HA were obtained by FTIR, SEM, EDS, BET and XPS. The chemisorption of Ni(II) ions by BC-HA conforms to the quasi-second-order kinetic model. Ni(II) ions are distributed on the heterogeneous surface of BC-HA by multimolecular layer adsorption, which accords with the Freundlich isotherm model. WV promotes better binding of HA and BC by introducing more active sites, thus increasing the adsorption capacity of Ni(II) ions on BC-HA. Ni(II) ions in soil are anchored to BC-HA by physical and chemical adsorption, electrostatic interaction, ion exchange and synergy.
35,000 years of recurrent visits inside Nerja cave (Andalusia, Spain) based on charcoals and soot micro-layers analyses
Authors: Medina-Alcaide Mª Ángeles , Vandevelde Ségolène , Quiles Anita , Pons-Branchu Edwige , Intxaurbe Iñaki , Sanchidrián José Luis , Valladas Hélène , Deldicque Damien , Ferrier Catherine , Rodríguez Eva , Garate Diego
Published: April 2023

Charcoal and micro-layers of soot trapped in speleothems from the inner galleries of Nerja Cave were analysed through an interdisciplinary study. The absolute dating of the prehistoric subterranean activity of the cave and the identification of different phases of visits to the deep parts are presented and discussed. The charcoal analysis includes anthracological analysis and SEM–EDX. The soot analysis includes optical microscopy, Raman spectroscopy and TEM–EDX, and the microcounting of soot microlayers. The 14C dating of 53 charcoals identified 12 phases of prehistoric visits to the cave between 41,218 and 3299 cal. BP, putting back the origin of human occupation of this emblematic cave by 10,000 years. The interdisciplinary analysis of the soot microlayers allowed us to perform a high-precision zoom on the last three visitation phases identified by Bayesian analysis (8003–2998 cal. BP.), demonstrating that these phases contain at least 64 distinct incursions, with an average of one visit every 35 years for the Neolithic period. Spatial analysis showed that not all areas of the cave were used in the same periods, highlighting the repetition of visits to certain specific sectors of the Lower Galleries of the cave. Lastly, the anthracological data indicate a cross-cultural and unique use of Pinus tp. sylvestris-nigra wood for lighting activities over an extended period between the Gravettian and Upper Magdalenian.
Production and characterization of anthocyanin-rich beer from black wheat by an efficient isolate Saccharomyces cerevisiae CMS12
Authors: Singh Arshpreet , Singh Saumya , Kansal Sushil K. , Garg Monika , Krishania Meena
Published: April 2023

Beer is the world’s third most popular fermented beverage. It is typically made from malted barley. Tropical countries must import barley from temperate countries for brewing, which is an expensive process. Therefore, it is critical to investigate alternative possible substrates for beer production in order to meet the growing demand for high-nutritional-quality beer. The current study involves the creation of a fermented beverage from anthocyanin-rich black wheat with the help of yeast, Saccharomyces cerevisiae CMS12, isolated from fruit waste. Characterization (UV, HPLC, NMR, FTIR, and ICPMS) was then performed, as well as a comparative study with white (amber) wheat beer. Further, process parameters optimization included initial sugar concentration, inoculum size, and pH. Black wheat wort contained 568 mg GAE/L total phenolic content, 4.67 mg/L anthocyanin concentration, 6.8% (v/v) alcohol content, and a pH of 4.04. The sensory analysis revealed that black wheat beer was more acceptable than white wheat beer. The developed fermented beverage has enormous commercialization potential.
Long-term outcomes of patients with primary intestinal follicular lymphoma managed with watch-and-wait strategy
Authors: Iwamuro Masaya , Tanaka Takehiro , Ennishi Daisuke , Matsueda Kazuhiro , Yoshioka Masao , Miyahara Koji , Sakaguchi Chihiro , Nishimura Mamoru , Nagahara Teruya , Mannami Tomohiko , Takenaka Ryuta , Oka Shohei , Inoue Masafumi , Takimoto Hidetaka , Inaba Tomoki , Kobayashi Sayo , Toyokawa Tatsuya , Tsugeno Hirofumi , Suzuki Seiyuu , Sawada Sachiko , Tanaka Shouichi , Tsuzuki Takao , Okada Hiroyuki
Published: April 2023

Patients with primary intestinal follicular lymphoma are often followed-up without a specific treatment, and this approach is called the “watch-and-wait approach.” However, the long-term outcomes of this patient group have not been sufficiently investigated. We enrolled patients with primary intestinal follicular lymphoma who were diagnosed before 2016 and managed with the watch-and-wait approach in 20 institutions. We retrospectively investigated the overall, disease-specific, and event-free survival rates as well as the rate of spontaneous regression. Among the 248 patients with follicular lymphoma with gastrointestinal involvement, 124 had localized disease (stage I or II1). We analyzed the data of 73 patients who were managed using the watch-and-wait approach. During the mean follow-up period of 8.3 years, the follicular lymphoma had spontaneously resolved in 16.4% of the patients. The 5-year and 10-year overall survival rates were 92.9% and 87.1%, respectively. With disease progression (n = 7), initiation of therapy (n = 7), and histologic transformation to aggressive lymphoma (n = 0) defined as events, the 5-year and 10-year event-free survival rates were 91.1% and 86.9%, respectively. No patient died of progressive lymphoma. Thus, both 5-year and 10-year disease-specific survival rates were 100%. In conclusion, an indolent long-term clinical course was confirmed in the patients with primary intestinal follicular lymphoma. The watch-and-wait strategy is a reasonable approach for the initial management of these patients.
Genetic susceptibility for autoimmune diseases and white blood cell count
Authors: Vaitinadin Nataraja Sarma , Stein C. Michael , Mosley Jonathan D. , Kawai Vivian K.
Published: April 2023

Some autoimmune (AI) conditions affect white blood cell (WBC) counts. Whether a genetic predisposition to AI disease associates with WBC counts in populations expected to have low numbers of AI cases is not known. We developed genetic instruments for 7 AI diseases using genome-wide association study summary statistics. Two-sample inverse variance weighted regression (IVWR) was used to determine associations between each instrument and WBC counts. Effect size represents change in transformed WBC counts per change in log odds-ratio of the disease. For AI diseases with significant associations by IVWR, polygenic risk scores (PRS) were used to test for associations with measured WBC counts in individuals of European ancestry in a community-based (ARIC, n = 8926), and a medical-center derived cohort (BioVU, n = 40,461). The IVWR analyses revealed significant associations between 3 AI diseases and WBC counts: systemic lupus erythematous (Beta = − 0.05 [95% CI, − 0.06, − 0.03]), multiple sclerosis (Beta =  − 0.06 [− 0.10, − 0.03]), and rheumatoid arthritis (Beta = 0.02 [0.01, 0.03]). PRS for these diseases showed associations with measured WBC counts in ARIC and BioVU. Effect sizes tended to be larger among females, consistent with the known higher prevalence of these diseases among this group. This study shows that genetic predisposition to systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis was associated with WBC counts, even in populations expected to have very low numbers of disease cases.