bluuebunny/crossref_metadata_2025 huggingface dataset:
Progression Free Survival, Overall Survival, and Relapse Rate in Endometrioid Ovarian Cancer and Synchronous Endometrial-Ovarian Endometrioid Cancer (SEO-EC): Results from a Large Retrospective Analysis
Authors: Pecorino Basilio , Laganà Antonio Simone , Chiantera Vito , Ferrara Martina , Di Stefano Andrea Benedetto , Di Donna Mariano Catello , Sorrentino Felice , Nappi Luigi , Mikuš Mislav , Scollo Paolo
Published: November 2022

Background and Objectives: We aimed to evaluate Progression Free Survival (PFS), Overall Survival (OS), and relapse rate in women affected by endometrioid ovarian cancer and synchronous endometrial-ovarian endometrioid cancer (SEO-EC). As secondary outcome, we assessed whether systematic pelvic and para-aortic lymphadenectomy could be considered a determinant of relapse rate in this population. Materials and Methods: We performed a retrospective analysis of women with diagnosis of endometrioid ovarian cancer or SEO-EC between January 2010 to September 2020, and calculated PFS, OS and relapse rate. Results: In almost all the patients (97.6%) who underwent systematic pelvic and para-aortic lymphadenectomy, there were no lymph node metastases confirmed by histology. We did not find a significant difference (p = 0.6570) for the rate of relapse in the group of women who underwent systematic pelvic and para-aortic lymphadenectomy (4/42; 9.5%) compared with the group of women who did not undergo the same procedure (1/21; 4.8%). During a median follow-up was 23 months, both PFS and OS were excellent. Conclusions: Women affected by early-stage low-grade endometrioid cancer and SEO-EC without apparent lymph node involvement at pre-operative imaging showed a very low rate of lymph node metastasis and similar relapse rate with or without lymphadenectomy.
Enhancing Bioactive Saponin Content of Raphanus sativus Extract by Thermal Processing at Various Conditions
Authors: Yang Min , Hou Chih-Yao , Hsu Hsien-Yi , Hazeena Sulfath Hakkim , Santoso Shella Permatasari , Yu Cheng-Chia , Chang Chao-Kai , Gavahian Mohsen , Hsieh Chang-Wei
Published: November 2022

Pickled radish (Raphanus sativus) is a traditional Asian ingredient, but the traditional method takes decades to make this product. To optimize such a process, this study compared the saponin content of pickled radishes with different thermal processing and traditional processes (production time of 7 days, 10 years, and 20 years) and evaluated the effects of different thermal processes on the formation of radish saponin through kinetics study and mass spectrometry. The results showed that increasing the pickling time enhanced the formation of saponin in commercial pickled radishes (25 °C, 7 days, 6.50 ± 1.46 mg g−1; 3650 days, 23.11 ± 1.22 mg g−1), but these increases were lower than those induced by thermal processing (70 °C 30 days 24.24 ± 1.01 mg g−1). However, it was found that the pickling time of more than 10 years and the processing temperature of more than 80 °C reduce the saponin content. Liquid chromatography–mass spectrometry (LC-MS) analysis showed that the major saponin in untreated radish was Tupistroside G, whereas treated samples contained Asparagoside A and Timosaponin A1. Moreover, this study elucidated the chemical structure of saponins in TPR. The findings indicated that thermal treatment could induce functional saponin conversion in plants, and such a mechanism can also be used to improve the health efficacy of plant-based crops.
Selective Structural Derivatization of Flavonoid Acetamides Significantly Impacts Their Bioavailability and Antioxidant Properties
Authors: Isika Daniel Kasungi , Sadik Omowunmi A.
Published: November 2022

Flavonoids show abundant favorable physicochemical and drug related properties, leading to substantial biological applications which are limited by undesirable properties such as poor solubility, high polarity, low bioavailability, and enzymatic degradations. Chemical modification with bioisosteres can be used to address some of these challenges. We report the synthesis and characterization of partial flavonoid acetamide derivatives from quercetin, apigenin and luteolin and the evaluation of their structure-activity relationships based on antioxidant, bioavailability, drug likeness, and toxicity properties. The sequential synthesis was achieved with 76.67–87.23% yield; the structures of the compounds were confirmed using 1H & 13C NMR characterizations. The purity of each compound was determined by HPLC while the molecular weights were determined by mass spectrometry. The % bioavailability was determined using the dialysis tubing procedure and the values were in the range 15.97–38.12%. The antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and expressed as the IC50 values which were in the range 31.52–198.41 µM. The drug likeness and the toxicity properties of compounds 4, 5, 7, 11 and 15 were predicted using computational tools and showed satisfactory results. A structure-activity relationship evaluation reveals that hydroxyl and methylene groups attached on the 2-phenylchromen-4-one structure of the flavonoid play a colossal role in the overall antioxidant and bioavailability properties. The improved bioavailability and excellent drug relevance and toxicity properties present flavonoid acetamide derivatives as prospective drug candidates for further evaluations.
Development and Psychometric Characteristics of an Instrument to Assess Parental Feeding Practices to Promote Young Children’s Eating Self-Regulation: Results with a Portuguese Sample
Authors: Gomes Ana Isabel , Roberto Magda Sofia , Pereira Ana Isabel , Alves Cátia , João Patrícia , Dias Ana Rita , Veríssimo João , Barros Luísa
Published: November 2022

A parental child-centered feeding approach is likely to keep children’s biological mechanisms activated while eating, protecting them in an obesogenic context. However, few feeding practice measures assess parents’ behaviors to guide and prompt children to identify and respond appropriately to their signs of hunger and satiety. We aimed to develop and study the reliability, validity, and measurement invariance of a new scale to assess parental feeding practices to promote children’s self-regulation of food intake. To pursue this aim, we conducted two descriptive, cross-sectional, online studies in Portugal in an online format; a total of 536 parents of 2- to 6-year-old children completed the evaluation protocol. Factorial analysis findings support the theoretical organization proposed for the scale. The confirmatory factorial analysis supported a first-order factor structure with two subscales, Prompting for eating self-regulation and Teaching about eating consequences, with eight items in total. Both scales presented good internal consistency and adequate temporal stability, with a significant, positive, and moderate relationship. The results showed metric invariance for the child’s sex. Both types of practices were positively correlated with the child’s enjoyment of food. Prompting for eating self-regulation showed negative associations with parents’ emotional lack of control, children’s satiety responsiveness, slowness in eating, and fussiness. Preliminary studies confirmed both the validity and reliability of the instrument and the adequacy of adopting a self-regulatory approach when assessing child-centered feeding practices. Combining this instrument with others that assess coercive practices can be beneficial to capture ineffective parents’ behaviors on children’s eating self-regulation.
Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life: A Comparative Study with Infants at Term
Authors: Castillo Salinas Félix , Montaner Ramón Alicia , Castillo Ferrer Félix-Joel , Domingo-Carnice Adrià , Cordobilla Begoña , Domingo Joan Carles
Published: November 2022

An observational comparative study was designed to assess the fatty acids profile in erythrocyte membrane phospholipids of 30 preterm neonates (<32 weeks gestation) at birth and after 1 month of life versus a convenience sample of 10 infants born at term. The panel of fatty acids included the families and components of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and n-6 and n-3 polyunsaturated fatty acids (PUFAs) as well as enzyme activity indexes and fatty acids ratios. At birth, the comparison of fatty acid families between preterm and term neonates showed a significantly higher content of SFAs and n-6 PUFAs, and a significantly lower content of MUFAs and n-3 PUFAs in the preterm group. After 30 days of life, significantly higher levels of n-6 PUFAs and significantly lower levels of n-3 PUFAs among preterm neonates persisted. At 30 days of birth, n-6 PUFA/n-3 PUFA and arachidonic acid (ARA) ARA/DHA remained significantly elevated, and DHA sufficiency index significantly decreased in the preterm group. The pattern of n-3 PUFA deficiency at birth and sustained for the first month of life would support the need of milk banking fortified with DHA and the use of DHA supplementation in breastfeeding mothers.
Unravelling the Complex Relationship between Diet and Nephrolithiasis: The Role of Nutrigenomics and Nutrigenetics
Authors: D’Ambrosio Viola , Ferraro Pietro Manuel , Lombardi Gianmarco , Friso Simonetta , Gambaro Giovanni
Published: November 2022

Nephrolithiasis is an increasingly prevalent condition, especially in high income countries, and is associated with high morbidity. Extraordinary progress in genetics made the identification of genetic forms of nephrolithiasis possible. These genetic diseases are usually rare and do not account for the most common forms of nephrolithiasis that are the result of several factors such as environment, dietary habits, and predisposing genes. This knowledge has shaped what we classify as nephrolithiasis, a condition that is now recognized as systemic. How and to what extent all these factors interact with one another and end in kidney stone formation, growth, and recurrence is not completely understood. Two new research fields have recently been trying to give some answers: nutrigenomics and nutrigenetics. These fields have the aim of understanding the intricate diet/genome interface that influences gene expression regulation mainly through epigenetic mechanisms and results in specific medical conditions such as cancer, metabolic syndrome, and cardiovascular diseases. Epigenetics seems to play a crucial role and could represent the link between environmental factors, that we are constantly exposed to, and risk factors for nephrolithiasis. In this systematic review, we summarize all the available evidence of proven or hypothesized epigenetic mechanisms related to nephrolithiasis.
The Relationship between Nutrient Intake and Cataracts in the Older Adult Population of Korea
Authors: Lee Sangyun , Lee Soyeon , Jeong Myeonghyeon , Jung Sunwoo , Lee Myoungjin , Yoo Sunyong
Published: November 2022

Cataracts are a prevalent ophthalmic disease worldwide, and research on the risk factors for cataracts occurrence is actively being conducted. This study aimed to investigate the relationship between nutrient intake and cataracts in the older adult population in Korea. We analyzed data from Korean adults over the age of 60 years (cataract: 2137, non-cataract: 3497) using the Korean National Health and Nutrition Examination Survey. We performed univariate simple and multiple logistic regressions, adjusting for socio-demographic, medical history, and lifestyle, to identify the associations between nutrient intake and cataracts. A higher intake of vitamin B1 in the male group was associated with a lower incidence of cataracts. A lower intake of polyunsaturated fatty acids and vitamin A, and a higher intake of vitamin B2 in the female group were associated with a higher incidence of cataracts. Our study demonstrated that polyunsaturated fatty acids, vitamin A, and vitamin B2 could affect the incidence of cataracts according to sex. The findings could be used to control nutrient intake for cataract prevention.
Selected Aspects of Nutrition in the Prevention and Treatment of Inflammatory Bowel Disease
Authors: Panufnik Paulina , Więcek Martyna , Kaniewska Magdalena , Lewandowski Konrad , Szwarc Paulina , Rydzewska Grażyna
Published: November 2022

Inflammatory bowel disease has become a global health problem at the turn of the 21st century. The pathogenesis of this disorder has not been fully explained. In addition to non-modifiable genetic factors, a number of modifiable factors such as diet or gut microbiota have been identified. In this paper, the authors focus on the role of nutrition in the prevention of inflammatory bowel disease as well as on the available options to induce disease remission by means of dietary interventions such as exclusive and partial enteral nutrition in Crohn’s disease, the efficacy of which is reported to be comparable to that of steroid therapy. Diet is also important in patients with inflammatory bowel disease in the remission stage, during which some patients report irritable bowel disease-like symptoms. In these patients, the effectiveness of diets restricting the intake of oligo-, di-, monosaccharides, and polyols is reported.
The Effect of TGFβ1 in Adipocyte on Inflammatory and Fibrotic Markers at Different Stages of Adipocyte Differentiation
Authors: Maharjan Babu Raja , McLennan Susan V. , Twigg Stephen M. , Williams Paul F.
Published: November 2022

Transforming growth factor beta (TGFβ) is a versatile cytokine. Although a profibrotic role of TGFβ is well established, its effect on tissue inhibitor of metalloproteinase (TIMPs) and inflammatory mediators are incompletely described. This study investigates the profibrotic and pro-inflammatory role of TGFβ1 during adipocyte differentiation. NIH3T3L1 cells were used for the in vitro study and were differentiated by adding a standard differentiation mix either with rosiglitazone (R-Diff) or without (S-Diff). Recombinant TGFβ1 (2 ng/mL) was added to the undifferentiated preadipocyte during the commitment stage and at the terminal differentiation stage. TGFβ1 treatment significantly decreased adiponectin mRNA at both early commitment (>300 fold) and terminal differentiated cells [S-Diff (~33%) or R-Diff (~20%)]. TGFβ1 upregulated collagen VI mRNA and its regulators connective tissue growth factor (CCN2/CTGF), TIMP1 and TIMP3 mRNA levels in undifferentiated preadipocytes and adipocytes at commitment stage. But in the terminal differentiated adipocytes, changes in mRNA and protein of collagen VI and TIMP3 mRNA were not observed despite an increase in CCN2/CTGF, TIMP1 mRNA. Although TGFβ1 upregulated interleukin-6 (IL6) and monocyte chemoattractant protein-1 (MCP1) mRNA at all stages of differentiation, decreased tumor necrosis factor-α (TNFα) mRNA was observed early in adipocyte differentiation. This study highlights the complex role of TGFβ1 on extracellular matrix (ECM) remodeling and inflammatory markers in stimulating both synthetic and inhibitory markers of fibrosis at different stages of adipocyte differentiation.
Formulation of Lipid-Based Nanoparticles for Simultaneous Delivery of Lapatinib and Anti-Survivin siRNA for HER2+ Breast Cancer Treatment
Authors: Eljack Sahar , David Stephanie , Chourpa Igor , Faggad Areeg , Allard-Vannier Emilie
Published: November 2022

In this work, lipid-based nanoparticles (LBNP) were designed to combine tyrosine kinase inhibitor (TKI) Lapatinib (LAPA) with siRNA directed against apoptosis inhibitor protein Survivin (siSurvivin) in an injectable form. This nanosystem is based on lipid nanocapsules (LNCs) coated with a cationic polymeric shell composed of chitosan grafted through a transacylation reaction. The hydrophobic LAPA is solubilized in the inner oily core, while hydrophilic siRNA is associated electrostatically onto the nanocarrier’s surface. The co-loaded LBNP showed a narrow size distribution (polydispersity index (PDI) < 0.3), a size of 130 nm, and a slightly positive zeta potential (+21 mV). LAPA and siRNA were loaded in LBNP at a high rate of >90% (10.6 mM) and 100% (4.6 µM), respectively. The siRNA-LAPA_LBNP was readily uptaken by the human epidermal growth factor receptor 2 overexpressed (HER2+) breast cancer cell line SK-BR-3. Moreover, the cytotoxicity studies confirmed that the blank chitosan decorated LBNP is not toxic to the cells with the tested concentrations, which correspond to LAPA concentrations from 1 to 10 µM, at different incubation times up to 96 h. Furthermore, siCtrl.-LAPA_LBNP had a more cytotoxic effect than Lapatinib salt, while siSurvivin-LAPA_LBNP had a significant synergistic cytotoxic effect compared to siCtrl.-LAPA_LBNP. All these findings suggested that the developed modified LBNP could potentiate anti-Survivin siRNA and LAPA anti-cancer activity.
An Algorithm to Extract the Boundary and Center of EUV Solar Image Based on Sobel Operator and FLICM
Authors: Li Shuai , Zhang Jianhua , Liu Bei , Jiang Chengzhi , Ren Lanxu , Xue Jingjing , Song Yansong
Published: November 2022

An algorithm to extract the disk boundary and center of EUV solar image using the Sobel operator, Fuzzy Local Information C-Means Clustering algorithm (FLICM), and the least square circle fitting method is proposed in this paper. The Sobel operator can determine the solar disk boundary preliminarily, and then the image is processed further using the FLICM algorithm. After the background is removed based on the clustered image and the boundary points can be highlighted, these points are fitted using the least square circle fitting method as the final boundary circle. The solar data used in this paper was from the observation of the Solar Dynamics Observatory Atmospheric Imaging Assembly (SDO/AIA) instrument. The 2523 19.3 nm solar images covering solar minimum, moderate solar activity, and more active suns were calculated using the proposed algorithm to analyze the accuracy statistically. The statistical comparison results demonstrate that the method is accurate and effective. This method can support the processing of solar EUV images and serve the operational system of a space weather forecast.
Numerical and Experimental Studies on the Micro-Doppler Signatures of Freely Flying Insects at W-Band
Authors: Diyap Murat , Zadeh Ashkan Taremi , Moll Jochen , Krozer Viktor
Published: November 2022

Remote sensing techniques in the microwave frequency range have been successfully used in the context of bird, bat and insect measurements. This article breaks new ground in the analysis of freely flying insects by using a continuous-wave (CW) radar system in W-band, i.e., higher mm-wave frequencies, by measuring and analyzing the micro-Doppler signature of their wing beat motion. In addition to numerical and experimental methods, the investigation also includes the development of a new signal processing method using a cepstrogram approach in order to automatically determine the wing beat frequency. In this study, mosquitoes (culex pipiens) and bees (apis mellifera) are considered as model insects throughout the measurement campaign. It was found that 50 independent micro-Doppler measurements of mosquitoes and bees can be clearly distinguished from each other. Moreover, the proposed radar signal model accurately matches the experimental measurements for both species.
Assessing Corneal Endothelial Damage Using Terahertz Time-Domain Spectroscopy and Support Vector Machines
Authors: Chen Andrew , Harris Zachery B. , Virk Arjun , Abazari Azin , Varadaraj Kulandaiappan , Honkanen Robert , Arbab Mohammad Hassan
Published: November 2022

The endothelial layer of the cornea plays a critical role in regulating its hydration by actively controlling fluid intake in the tissue via transporting the excess fluid out to the aqueous humor. A damaged corneal endothelial layer leads to perturbations in tissue hydration and edema, which can impact corneal transparency and visual acuity. We utilized a non-contact terahertz (THz) scanner designed for imaging spherical targets to discriminate between ex vivo corneal samples with intact and damaged endothelial layers. To create varying grades of corneal edema, the intraocular pressures of the whole porcine eye globe samples (n = 19) were increased to either 25, 35 or 45 mmHg for 4 h before returning to normal pressure levels at 15 mmHg for the remaining 4 h. Changes in tissue hydration were assessed by differences in spectral slopes between 0.4 and 0.8 THz. Our results indicate that the THz response of the corneal samples can vary according to the differences in the endothelial cell density, as determined by SEM imaging. We show that this spectroscopic difference is statistically significant and can be used to assess the intactness of the endothelial layer. These results demonstrate that THz can noninvasively assess the corneal endothelium and provide valuable complimentary information for the study and diagnosis of corneal diseases that perturb the tissue hydration.
Adoption of Blockchain Technology Facilitates a Competitive Edge for Logistic Service Providers
Authors: Noor Adeeb
Published: November 2022

Blockchain is attracting tremendous attention in the logistics industry on account of its cutting-edge appeal, potential for integration within the sector, and capacity to disrupt established practices. Among other things, blockchain technology promises to open up new horizons in traceability, transparency, accuracy, and safety throughout the supply chain. However, as an emerging technology, blockchain is still relatively nascent, and familiarity with the technology is limited, as are its implementations. In addition, there is a dearth of studies concerning blockchain technology specifically, as it pertains to transport and logistics, as opposed to finance and cryptocurrency. It remains unknown what factors enable blockchain adoption by logistics service providers and how its adoption affects firm performance and capabilities. This research examines extant literature and conducts research on an eminent global transportation company to elucidate the potential influence of blockchain adoption on firm performance. The results of this work support the model that advancing theory-driven and empirical blockchain studies will increase firm capabilities and foster a competitive edge in the emerging digitalized era.
Design and Validation of Lifetime Extension Low Latency MAC Protocol (LELLMAC) for Wireless Sensor Networks Using a Hybrid Algorithm
Authors: Hai Tao , Zhou Jincheng , Padmavathy T. V. , Md Abdul Quadir , Jawawi Dayang N. A. , Aksoy Muammer
Published: November 2022

As the battery-operated power source of wireless sensor networks, energy consumption is a major concern. The medium-access protocol design solves the energy usage of sensor nodes while transmitting and receiving data, thereby improving the sensor network’s lifetime. The suggested work employs a hybrid algorithm to improve the energy efficiency of sensor networks with nodes that are regularly placed. Every node in this protocol has three operating modes, which are sleep mode, receive mode, and send mode. Every node enters a periodic sleep state in order to conserve energy, and after waking up, it waits for communication. During the sleep mode, the nodes turn off their radios in order to reduce the amount of energy they consume while not in use. As an added feature, this article offers a channel access mechanism in which the sensors can send data based on the Logical Link Decision (LLD) algorithm and receive data based on the adaptive reception method. It is meant to select acceptable intermediary nodes in order to identify the path from the source to the destination and to minimize data transmission delays among the nodes in the network scenario. Aside from that, both simulation and analytical findings are used to examine the activity of the suggested MAC, and the created models are evaluated depending on their performance. With regard to energy consumption, latency, throughput, and power efficiency, the result demonstrates that the suggested MAC protocol outperforms the corresponding set of rules. The extensive simulation and analytical analysis showed that the energy consumption of the proposed LELLMAC protocol is reduced by 22% and 76.9% the end-to-end latency is 84.7% and 87.4% percent shorter, and the throughput is 60.3% and 70.5% higher than the existing techniques when the number of node is 10 and 100 respectively.
Influence of the Government Department on the Production Capacity Reserve of Emergency Enterprises Based on Multi-Scenario Evolutionary Game
Authors: You Xinshang , Zhao Shuo , Yang Yanbo , Zhang Dongli
Published: November 2022

With the frequent occurrence of world emergency events, the emergency management of government departments in various countries is facing great challenges. In the context of the COVID-19 pandemic, the shortage of various emergency resources is prominent, and the emergency supplies reserve combined by governments and enterprises is an important guarantee for dealing with emergency management problems. This paper mainly studies the impact of a government sustainability-oriented innovation policy on the production capacity reserve of security emergency enterprises (SEEs), and constructs an evolutionary game model between the local government and SEEs. Then, it focuses on the impact of a reputation mechanism on the government enterprise cooperative reserve. According to the condition of a country, the central government’s punishment mechanism is introduced, and the evolutionary and stable strategies of the behavior choices of the local government and SEEs are compared and analyzed. Combined with the evolution degree of emergency events, the numerical simulation analysis is used to deduce and simulate the multi scenario of the example model. The results show that the reputation mechanism can effectively promote the evolution of government and enterprises to the ideal state under various scenarios. When the punishment intensity of the central government is higher than the total benefit of the implementation of the mere formality policy by the local government, it can effectively prevent the omission of the local government. This study provides a new idea for the government to formulate reasonable policies to promote SEEs to reserve production capacity, which is more conducive to government enterprise cooperation to deal with emergency events.
Assessment of Rainwater Harvesting Facilities Tank Size Based on a Daily Water Balance Model: The Case of Korea
Authors: Khan Amjad , Park Yoonkyung , Park Jongpyo , Kim Reeho
Published: November 2022

Factors affecting rainwater resource management for the present and future include population growth, urbanization, and climate change. Rainwater harvesting (RWH) allows multiple urban water-related issues to be mitigated. In this study, a spreadsheet-based daily water balance model was developed to analyze the existing laws and regulations regarding the storage tank size of RWH facilities. Six buildings at different locations were selected for this study. Two are office buildings, two are school buildings, and two are sports buildings. The term “RWH facility evaluation criteria” is collectively used for rainwater supply satisfaction rate, rainwater guarantee rate, and rainwater utilization rate. A green roof can hold the rainwater for some time, reducing the peak flow and runoff volume. The results provide evidence that, among the selected studied buildings, buildings having a combination of a green roof and RWH facility score the highest in terms of RWH facility evaluation criteria, even though the actual tank size is much smaller than the standard tank size. This is the case with the Yesan County Office, in which a green roof connected to a small (66 m3) rainwater storage tank is installed. As a green roof can decrease the runoff volume, the rainwater can be managed efficiently with less pumping energy and only a small storage tank.
Spatiotemporal Patterns of Extreme Precipitation Events over Jhelum River Basin
Authors: Ahmad Ijaz , Wang Li , Ali Faisal , Zhang Fan
Published: November 2022

Climate change has a wide range of impacts on Pakistan’s water resources system, followed by increased magnitude, frequency and intensity of extreme events. Therefore, investigating the variations in extreme climatic events is vital in planning and developing agriculture and water conservation projects. Hence, the present study investigated the spatiotemporal variability of extreme precipitation indices (EPIs) over the Jhelum River basin (JRB) using the Mann-Kendall (MK) and innovative trend analysis (ITA) methods. In addition, variations in the event-based extreme precipitation (EEPs) and time distribution patterns (TDPs) were analyzed because EPIs considered the daily precipitation values only and the combined effect of the extreme events that last for more than 1 day were often neglected. The results show that the fixed and station-related EPIs, i.e., R10, R20, R25, CWD, Prcpt and R95p, exhibited significant decreasing trends at 06, 05, 04, 04, 07 and 05 stations, whereas an increasing trend was evident for consecutive dry days (CDD) at nine stations with a magnitude of 0.33 days/year, indicating a rise in the drought events compared to floods. Moreover, precipitation events with an amount of 40–290 mm, duration of 4–7 days and concentration ratio of 0.7–0.95 were found to be dominant across JRB. Therefore, an increase in the CDD and a decrease in the consecutive wet days (CWD) may change the magnitude, intensity and frequency of extreme precipitation events and consequently pressure the availability of water resources. Therefore, the findings of this study may help understand the precipitation variability over JRB and play a pivotal role in future development projects.
Numerical Analysis of a TEG and mPCM Enhancement System for BIPVs Using CFD
Authors: Kang Yong-Kwon , Joung Jaewon , Kim Minseong , Lee Hyun-Hwa , Jeong Jae-Weon
Published: November 2022

Building-integrated photovoltaics (BIPVs) are the most promising systems for net-zero energy buildings. However, there are few practical cases because of shortcomings, such as the lack of solar tracking and the rapid rise in PV surface temperature. Therefore, methods of increasing the efficiency of BIPVs have been proposed and studied. These include using phase change material (PCM) or heat fins, wavelength selection, decreasing the PV surface temperature, or using a thermoelectric generator (TEG) and convection cooling to utilize the waste heat from the PV. Many preceding studies have been conducted on TEG and convection heat dissipation methods to utilize as much waste heat as possible. Therefore, in this study, a TEG–PCM hybrid system using mPCM was proposed to improve constructability. Herein, the appropriate phase change temperature of the PCM, the heat fin spacing in the PCM container, and the TEG arrangement were analyzed through computational fluid dynamics (CFD)-based simulations. The appropriate melting temperature of the PCM, the heat fin interval, and the arrangement of the TEG for the proposed system are 25 °C, 20 mm, and 140 mm, respectively. In order to achieve optimal efficiency, it is necessary to consider an appropriate amount of heat transfer, and it has been confirmed that if there are too many thermoelectric elements, the opposite effect occurs.
History and Future Challenges of Roadkill Research in South Korea
Authors: Hong Sungwon , Park Hee-Bok , Kim Mihyun , Kim Hyo Gyeom
Published: November 2022

Roadkill has been one of the most problematic issues with wildlife under urbanization. South Korea, one of the fastest industrializing countries in the world, has been affected by the same roadkill issues and has researched how to mitigate wildlife–vehicle collisions (WVCs). In the present study, we aimed to (i) review scientific studies concerning roadkill conducted in South Korea (51 domestic, 15 international papers, 19 reports, and 1 thesis), (ii) compare bibliographic networks between international and South Korean roadkill studies, and (iii) discuss future challenges. From a search in the core collection of Web of Science peer-reviewed papers published from 1992 to 2022, keywords were extracted to create a bibliometric visualization map, using VOSviewer. Among the 85 articles related to WVCs, those about eco-corridors have steadily increased since 1998, while mitigation system and roadkill articles have been published since the mid-2000s. With increased awareness, more systems have been established, and research related to WVCs has been increasingly established. Currently, there are two systematic roadkill monitoring systems in South Korea, and an increasing number of modeling studies have suggested where roadkill hotspots are located. How to mitigate roadkill incidents has also been explored. A comparison of associations between international and Korean research shows that the network structures of Korean society were more disconnected and less dispersed. In addition, the keywords were narrower than those used in studies from the international community. Although studies on landscape connectivity and road ecology are few, their number and scope in South Korea have increased and broadened. These studies could be more rapidly developed in the future as some systems are equipped.
Integrated Collaborative Governance Approaches towards Urban Transformation: Experiences from the CLEVER Cities Project
Authors: Bradley Sean , Mahmoud Israa H. , Arlati Alessandro
Published: November 2022

Within the framework of CLEVER Cities Horizon 2020, London, Milan, and Hamburg are putting in place nine Urban Living Labs in order to implement Nature-based Solutions that address urban challenges in socially disadvantaged neighborhoods. In this article, the means by which co-creation processes and pathways may lead to innovation in governance structures are considered. Through a comparative case study analysis, this research aims to identify integrated, collaborative governance frameworks that are complex and adaptive, as well as reflect the actual changes in governance in cities. Herein, ULLs are intended not just as a vehicle for place-based urban regeneration but also as a starting point for collaborative governance. In this article, it is considered how co-creation pathways may lead to innovation in current local governance structures and achieve transformational change. This paper analyzes the collaborative governance dynamic models at three points in time in the three cities. It is also considered how co-creation pathways may lead to innovation in current local governance structures and achieve transformational change.
Industrial Poverty Alleviation, Digital Innovation and Regional Economically Sustainable Growth: Empirical Evidence Based on Local State-Owned Enterprises in China
Authors: Lin Chuan , Zhai Haomiao , Zhao Yanqiu
Published: November 2022

This paper takes the industrial poverty alleviation of local state-owned enterprises in China as the research object, and takes the local state-owned enterprises listed in Shanghai and Shenzhen A shares in China from 2016 to 2020 as the sample to empirically test the impact of industrial poverty alleviation on the sustainable economic growth of the region and consider the regulatory effect of digital innovation. This study found that China’s local industrial poverty reduction behavior in state-owned enterprises can effectively promote regional economic growth. Moreover, the digital innovation produced a regulating effect; that is, if enterprises carry out digital innovation and have a higher degree of digital innovation, their industrial poverty alleviation behavior will have a stronger role in promoting regional economic growth. This conclusion still holds even after controlling for factors of robustness and endogeneity. In addition, the study of influence mechanisms found that the proportion of primary industry in GDP was the mediating effect of industrial poverty alleviation on regional economic growth, and the proportion of primary industry in GDP had a partial mediating effect. Further heterogeneous group testing shows that the impact of industrial poverty alleviation on regional economically sustainable growth is more obvious in agriculture-related, local state-owned enterprises; non-high-tech, local state-owned enterprises; and local state-owned enterprises with subsequent poverty alleviation plans. The empirical evidence in this paper verifies the role of local state-owned enterprises’ participation in industrial poverty alleviation in promoting regional economic growth. It is a useful supplement to the research literature on the economic consequences of Chinese enterprises’ participation in targeted poverty alleviation, which helps to better understand such a phenomenon and also provides a powerful explanation for China’s poverty alleviation achievements.
Assessment of 3D Geoportals of Cities According to CityGML Standard Guidelines
Authors: Maciąg Klaudia , Leń Przemysław
Published: November 2022

Along with the development of three-dimensional computer graphics, methods of collecting and making 3D spatial data available became a significant issue covering the interoperability of data derived from multiple sources. Between 2006 and 2008, the Open Geospatial Consortium designed a CityGML model as a proposal for a uniform classification, graphic representation, construction, and storage of 3D objects. A considerable part of three-dimensional visualisations, now gaining popularity, make use of solutions based on the CityGML standard, with which they are compatible to various degrees. The survey involved a comprehensive analysis of sixteen generally accessible 3D geoportals of cities in Europe, Asia, and North America in terms of their broad-sense functionality as well as technical and thematic compatibility with the assumptions of CityGML standards. The level of realisation of various features related to the provided spatial data services was evaluated, taking into account elements that the present-day world literature deems to be particularly desirable. The analysis resulted in an elaborate ranking of websites according to 21 criteria. The most common objects and features of the analysed geoportals were also detailed. In addition, the authors presented several solutions to improve the quality of three-dimensional geoportals of cities by implementing external data from various sources.
Is the Size of the City Important for the Quality of Urban Life? Comparison of a Small and a Large City
Authors: Petrikovičová Lucia , Kurilenko Victoria , Akimjak Amantius , Akimjaková Beáta , Majda Peter , Ďatelinka Anton , Biryukova Yulia , Hlad Ľubomír , Kondrla Peter , Maryanovich Daliborka , Ippolitova Lyubov , Roubalová Marie , Petrikovič Jozef
Published: November 2022

In the recent past, the question of determining the optimal city size in relation to the quality of urban life (QoUL) was raised of city inhabitants. This article has evaluated the correlation of the QoUL index in cities in relation to the number of inhabitants. We also deal with selected variables for which we assume a relationship with QoUL. The authors who calculated the indices of the quality of urban life equated the quality of life with its objective dimension considered as the quality of the place. It turned out that growth in the number of inhabitants of Slovak cities did not correlate with improving quality of life. Our article examined QoUL in two different countries on a scale of 0–10 through questionnaires. The obtained values are a subjective assessment. From a global point of view, one city is small and the other is big. The small city achieved better results in international rankings of quality of life, and it was assumed that this fact would also be reflected in the quantification of the quality of urban life. One hypothesis was that a small city will achieve better urban life quality values than a large city. The paper presents the results of measurement and correlation.
Can Decision Support Systems Help Improve the Sustainable Use of Fungicides in Wheat?
Authors: Prahl Ketel Christian , Klink Holger , Hasler Mario , Hagen Susanne , Verreet Joseph-Alexander , Birr Tim
Published: November 2022

Wheat is one of the most economically important field crops worldwide. Foliar diseases are a major threat to wheat productivity and are primarily managed by implementing less susceptible cultivars and using fungicides. With the “Farm to Fork” strategy under consideration by the European Union to reduce pesticide usage by 50% by 2030, this elucidates the importance of utilizing decision support systems (DSS) to optimize fungicide applications. Therefore, three DSSs of different origins, namely the IPM-Wheat Model Schleswig-Holstein (scientific), the ISIP system (federal), and the xarvio© FIELD MANAGER (commercial), were analysed under maritime climate conditions at three locations in a high input area of wheat cultivation in northern Germany from 2019 to 2021. Fungicide efficacy was evaluated for yield as well as for the management of prevalent pathogens (Septoria tritici blotch, glume blotch, tan spot, powdery mildew, stripe rust, and leaf rust) on two different commercially available cultivars (highly and moderately susceptible). Compared to a stage-oriented standard system, no significant decrease in yield was observed in both cultivars, despite up to a 50% reduction in fungicide use through the use of DSSs. This was attributed to an optimized timing of fungicide applications, which resulted in slightly lower but still tolerable disease suppression efficacy compared to the stage-oriented system. In conclusion, minor disease severities are often overestimated, and DSSs can help improve the sustainability of fungicide use in wheat and pesticides in general.
Review of the Applications of Kalman Filtering in Quantum Systems
Authors: Ma Kezhao , Kong Jia , Wang Yihan , Lu Xiao-Ming
Published: November 2022

State variable and parameter estimations are important for signal sensing and feedback control in both traditional engineering systems and quantum systems. The Kalman filter, which is one of the most popular signal recovery techniques in classical systems for decades, has now been connected to the stochastic master equations of linear quantum mechanical systems. Various studies have invested effort on mapping the state evolution of a quantum system into a set of classical filtering equations. However, establishing proper evolution models with symmetry to classical filter equation for quantum systems is not easy. Here, we review works that have successfully built a Kalman filter model for quantum systems and provide an improved method for optimal estimations. We also discuss a practical scenario involving magnetic field estimations in quantum systems, where non-linear Kalman filters could be considered an estimation solution.
Large-Scale Solar Wind Phenomena Affecting the Turbulent Cascade Evolution behind the Quasi-Perpendicular Bow Shock
Authors: Rakhmanova Liudmila S. , Riazantseva Maria O. , Zastenker Georgy N. , Yermolaev Yuri I.
Published: November 2022

The Earth’s magnetosphere is permanently influenced by the solar wind. When supersonic and superalfvenic plasma flow interacts with the magnetosphere, the magnetosheath region is formed, which is filled with shocked turbulent plasma. Varying SW parameters influence the mechanisms of formation of this boundary layer, including the dynamics of turbulence behind the bow shock. The effect of the solar wind on the development of turbulence in the magnetosheath was demonstrated recently based on broad statistics of spacecraft measurements. The present study considers the multipoint observations of turbulent fluctuations in the solar wind, in the dayside magnetosheath and at the flanks, to analyze the evolution of the turbulent cascade while the solar wind plasma enters the magnetosheath. Observations of the magnetosheath behind the quasi-perpendicular bow shock are analyzed to exclude the influence of the bow shock topology from consideration. Three basic types of solar wind flows are considered: slow undisturbed solar wind, compressed regions, and interplanetary manifestations of coronal mass ejections. The results show surviving Kolmogorov scaling behind the bow shock for steady solar wind flow and amplification of the compressive fluctuations at the kinetic scales at the magnetosheath flanks for the solar wind associated with compressed plasma streams. During interplanetary manifestations of the coronal mass ejection, the spectra in the dayside magnetosheath substantially deviate from those observed in the solar wind (including the absence of Kolmogorov scaling and steepening at the kinetic scales) and restore at the flanks.
Prevalence of Human Coronaviruses in Children and Phylogenetic Analysis of HCoV-OC43 during 2016–2022 in Riyadh, Saudi Arabia
Authors: Alamri Khalid A. , Farrag Mohamed A. , Aziz Ibrahim M. , Dudin Gani Asa , Mohammed Arif Ahmed , Almajhdi Fahad N.
Published: November 2022

With the emergence of SARS-CoV-2, routine surveillance combined with sequence and phylogenetic analysis of coronaviruses is urgently required. In the current study, the four common human coronaviruses (HCoVs), OC43, NL63, HKU1, and 229E, were screened in 361 clinical samples collected from hospitalized children with respiratory symptoms during four winter seasons. RT-PCR-based detection and typing revealed different prevalence rates of HCoVs across the four seasons. Interestingly, none of the four HCoVs were detected in the samples (n = 100) collected during the winter season of the COVID-19 pandemic. HCoV-OC43 (4.15%) was the most frequently detected, followed by 229E (1.1%). Partial sequences of S and N genes of OC43 from the winter seasons of 2015/2016 and 2021/2022 were used for sequence and phylogenetic analysis. Multiple sequence alignment of the two Saudi OC43s strains with international strains revealed the presence of sequence deletions and several mutations, of which some changed their corresponding amino acids. Glycosylation profiles revealed a number of O-and N-glycosylation sites in both genes. Based on phylogenetic analysis, four genotypes were observed with Riyadh strains grouped into the genotype C. Further long-term surveillance with a large number of clinical samples and sequences is necessary to resolve the circulation patterns and evolutionary kinetics of OC43 in Saudi Arabia.
Simultaneous Production of a Virus-Like Particle Linked to dsRNA to Enhance dsRNA Delivery for Yellow Head Virus Inhibition
Authors: Worawittayatada Jaruwan , Angsujinda Kitipong , Sinnuengnong Rapee , Attasart Pongsopee , Smith Duncan R. , Assavalapsakul Wanchai
Published: November 2022

A co-expressed Penaeus stylirostris densovirus (PstDNV) capsid and dsRNA specific to the yellow head virus (YHV) protease (CoEx cpPstDNV/dspro) has been shown to suppress YHV replication in the Pacific white-legged shrimp (Litopenaeus vannamei). However, maintaining two plasmids in a single bacterial cell is not desirable; therefore, a single plasmid harboring both the PstDNV capsid and the dsRNA-YHV-pro gene was constructed under the regulation of a single T7 promoter, designated pET28a-Linked cpPstDNV-dspro. Following induction, this novel construct expressed an approximately 37-kDa recombinant protein associated with a roughly 400-bp dsRNA (Linked cpPstDNV-dspro). Under a transmission electron microscope, the virus-like particles (VLP; Linked PstDNV VLPs-dspro) obtained were seen to be monodispersed, similar to the native PstDNV virion. A nuclease digestion assay indicated dsRNA molecules were both encapsulated and present outside the Linked PstDNV VLPs-dspro. In addition, the amount of dsRNA produced from this strategy was higher than that obtained with a co-expression strategy. In a YHV infection challenge, the Linked PstDNV VLPs-dspro was more effective in delaying and reducing mortality than other constructs tested. Lastly, the linked construct provides protection for the dsRNA cargo from nucleolytic enzymes present in the shrimp hemolymph. This is the first report of a VLP carrying virus-inhibiting dsRNA that could be produced without disassembly and reassembly to control virus infection in shrimp.