bluuebunny/crossref_metadata_2025 huggingface dataset:
Badut Jalanan: Badut yang Tak Lagi Dianggap Menghibur
Authors: Gymnastiar Tira Wicaksana  , Septianto Hary Prassetyo  , Fatach Toriqo Abimanyu
Published: May 2023

The occurrence of the '19 covid pandemic requires people to reduce activities, and even stop outdoor activities as an effort from policies carried out by the government to stop the spread of '19 covid. But of course, this policy makes people confused, especially people who have jobs that require them to leave the house and do outdoor activities. Not only that, the country's unstable economic condition also makes many companies in Indonesia decide to terminate their cooperation with employees unilaterally to maintain the financial stability of their companies. Therefore, during the pandemic, so much new unemployment was caused by layoffs. But because of this, many people have lost their jobs and those who lack the ability and skills in a field of work are forced to enter a job, or maybe it cannot also be called a job, namely begging, and one form of beggar today is street clowns. This research will focus on the figure of street clowns at the Mastrip Roundabout Red Light, as well as the background that makes them eventually become street clowns. This research is a research that uses qualitative methods with a phenomenological approach, and the theoretical basis used is the theory of Social Action proposed by Max Weber. Data collection using observation, interviews, and documentation.
Realitas Sosial Perempuan Bercadar : Penolakan Dan Penerimaan di Masyarakat Sumbersari Kabupaten Jember
Authors: Galuh Putri Rahayu  , Ida Tri Widiyaningsih  , Alina Ratna Anjali
Published: May 2023

Each religion has its own symbols and uniqueness. Islam is the dominant religion in Indonesia. Islamic women are usually symbolized by the hijab and long clothes. Not infrequently there are also Muslim women who wear the veil. The veil is a face covering for Muslim women that covers all parts of the face except for the eye area, which is combined with a hijab and long clothes which are usually dominated by dark colors. But in Indonesia itself, women who wear the veil reap many pros and cons. This research was conducted to find out how the interactions that occur between women who wear the veil and the surrounding community. This study uses a type of qualitative research with an ethnographic approach. Qualitative research helps researchers to obtain an answer to a symptom, fact or reality that is being faced and to be able to understand a problem that is being studied. Ethnography is the study of culturally shared groups involving the core values and beliefs of their members. The subjects of this study were students studying at several campuses in Jember Regency. The results showed that the motivation of the informants in wearing the veil was as a form of obedience to religion and also to protect and avoid bad things. Several informants stated that they experienced some difficulties in interacting with the surrounding community when they wore the veil. Not infrequently they also receive negative stigma from society. So this is also a big challenge for veiled women in Indonesia, especially in the area around Jember Regency.
Analisis Sistem Informasi Akuntansi Penggajian Karyawan
Authors: Aqib Sandro Erlangga  , Mulan Agalia Sabine
Published: May 2023

Sistem penggajian merupakan faktor yang penting dalam mencapai  tujuan suatu perusahaan, dimana sistem penggajian terdiri dari suatu  kerangka kerja yang saling berhubungan dalam suatu perusahaan yang  berfungsi menginformasikan data biaya tenaga kerja yang dibutuhkan oleh pihak-pihak yang berkepentingan pada perusahaan dan mengatur proses pembayaran atas jasa yang dilakukan oleh karyawan. Pembayaran gaji dan upah yang adil sesuai dengan kinerja dan prestasinya, maka akan berperngaruh positif terhadap bertambahnya nilai dan produktivitas perusahaan. Selain itu sistem akuntansi penggajian yang baik diharapkan mampu mengefektifkan dan mengefesiensikan dalam proses pelaksanaan penggajian, sehingga kendala ataupun permasalahan yang mungkin terjadi dapat dihindari.
Meningkatkan Kreativitas dan Pertunjukan Lagu Cangkurileung dalam Pengembangan Kesenian tari di Saung Angklung Udjo
Authors: Raissa Shafa Argyanti  , Syakilla Putri Syahrani
Published: May 2023

Dalam pembelajaran tari tentunya kreativitas dalam tari dapat dikembangkan dalam berbagai stimulus dan strategi pembelajaran yang akan diterapkan. Salah satunya melalui lagu cangkurileung, dari lagu tersebut penari diharapkan untuk dapat mengembangkan kemampuan kreativitas gerak melalui lagu. Penelitian ini bertujuan untuk mendeskripsikan penerapan lagu cangkurileung yang digunakan pada pengembangan kesenian tari. Saung Angklung Udjo adalah salah satu destinasi yang rutin melaksanakan pertunjukan Kesenian Sunda. Tulisan ini bertujuan untuk menjelaskan seni pertunjukan Saung Angklung Udjo dilihat dari aspek nilai budaya pariwisata, dengan menggunakan metode kualitatif. Hasil penelitian menunjukkan bahwa seni pertunjukan Saung Angklung Udjo adalah seni pertunjukan kesenian khas Jawa Barat yang berlatar belakang budaya Sunda, seperti wayang golek, haleran, tari topeng, calung, angklung, dengan alat musik tradisional, seperti calung dan angklung. Seni pertunjukan tersebut, menggambarkan seni tradisional yang memiliki daya tarik wisata dengan nilai-nilai budaya yang ada di dalamnya, yaitu nilai kehidupan manusia, nilai hubungan manusia dengan alam sekitar, nilai manusia dari aspek waktu, nilai manusia dari makna kerja dan amal perbuatan, serta nilai hubungan manusia dengan manusia yang lain. Maka dapat disimpulkan jika penerapan stimulus lagu cangkurileung pada pengembangan tari untuk meningkatkan kreativitas ini cocok dalam pembelajaran tari, serta stimulus diyakini dapat meningkatkan kreativitas para penari di Saung Angklung Udjo. Saung Aklung Udjo melakukan pertunjukan secara teratur serta mewariskan budaya sunda kepada anak-anak dengan mendidik mereka untuk menguasai seni tradisi sunda dan angklung secara gratis. Anak-anak tersebut akan tampil dalam pertunjukan, diberi honor sehingga diberi bantuan biaya sekolah. Saung Angklung Udjo di dirikan sebagai upaya untuk menyatukan kecintaan kepada anak-anak, seni tradisional, flora dan fauna, alam, serta lingkungan menjadi suatu harmoni, yang nyaman dilihat, didengar, dan dirasakan.
Penggunaan Bahasa Indonesia di Media Sosial
Authors: Ati Sandi Rohayati
Published: May 2023

Penelitian dalam bidang analisis sosiolinguistik telah banyak dilakukan untuk memahami penggunaan bahasa di media sosial, termasuk penggunaan bahasa Indonesia. Penelitian ini bertujuan untuk menganalisis dan menjelaskan fenomena penggunaan bahasa Indonesia di media sosial berdasarkan aspek sosiolinguistik. Metode penelitian yang digunakan adalah metode deskriptif dengan pengumpulan data melalui analisis makna pesan terhadap penelitian- penelitian terdahulu mengenai tema yang serupa. Penelitian ini memberikan pemahaman yang lebih baik tentang penggunaan bahasa Indonesia di media sosial dari perspektif sosiolinguistik. Penelitian selanjutnya dapat mengembangkan konsep-konsep baru dan teori-teori sosiolinguistik untuk memahami lebih jauh penggunaan bahasa di media sosial yang semakin kompleks dan beragam.
Arsitektur Lawang Sewu sebagai Landmark dan Destinasi Wisata Kota Semarang, Jawa Tengah
Authors: Esya Fairuz Nurfadillah  , Jason Derian Richardo
Published: May 2023

Lawang Sewu is a historic building owned by PT KAI in Operational Area 4 Semarang, Central Java. Lawang Sewu is a relic from the Dutch Colonial period. Now Lawang Sewu has become a cultural heritage building that is included in the building protection law. In this museum we can find the legacy of the old PT KAI. Lawang Sewu is also one of the leading tourist attractions in the city of Semarang and witnessed the 5-day battle in Semarang which took place from 14 to 19 August 1949 and is marked by the location of the Tugu Muda Monument which is on the west side of Lawang Sewu or more precisely at the Jalan Pandanaran roundabout. As an architectural and tourist object, Lawang Sewu has the value needed in the definition of a monument and monumental nature. These values include aspects of history, technology, architecture, and culture. Currently the Lawang Sewu building houses a collection of trains in Indonesia from time to time. Collections such as Alkmaar, Edmonson machines, calculating machines, typewriters, replica steam locomotives, securities, and several other collections. This place is also often used for community activities such as exhibitions, festivals, art performances, shooting, wedding parties and photo shoots.
Analisis Penerapan Standar Operasional Prosedur (SOP) Pada Departemen Inventory PT. Rimex International Indonesia Balikpapan
Authors: Isti Prabawani  , Yizrel Junus Kende  , Ratna Ratna
Published: May 2023

SOPs can be defined as documents that describe operational activities carried out daily, with the aim that the work is carried out correctly, precisely, and consistently, to produce products according to predetermined standards” (Tathagati, 2014). The existence of SOP will help the company to achieve company goals. To achieve company goals, the company provides a design in the form of an SOP that will guide employees in carrying out their duties and minimize errors in carrying out the responsibilities of each employee. This study aims to determine the application of standard operating procedures (SOP) in the Inventory Department at PT RIMEX International Indonesia Balikpapan. This type of research is qualitative concerning the 7 main points in the SOP which include efficiency, consistency, minimizing errors, problem-solving, and defense boundaries. There are 3 research informants: One supervisor, one Quality Control, and 1 Warehouseman. Data collection techniques through interviews. The results of the analysis show that Inventory Department employees have implemented the SOP made by the company. The problem found is that there are differences in goods between the recording of goods in the company's recording system and the physical goods between the recording of goods in the company's recording system and the physical goods in the warehouse, such as how many items are left, abandoned and how many items are left in the warehouse.
Pengelolaan Penataan Arsip Bagian SDM dan Umum PT. PELINDO IV (PERSERO) Cabang Balikpapan
Authors: Sari Rahmawati  , Alisa Alsina  , Darna Astriana
Published: May 2023

Archiving is a process or activity that starts from creation, receipt, collection, regulation, control, maintenance, care, and storage as well as evaluation according to a certain predetermined system. As time goes by and also the many activities that have been carried out at PT Pelindo IV (Persero) Balikpapan Branch, more and more archives have been created. The purpose of this study was to find out the causes of archive management and to find out the efforts made in overcoming obstacles to archive management in the HR and general division at PT Pelindo IV (Persero) Balikpapan Branch. The type of research used in this research is descriptive research with a qualitative approach in which data is collected through observations, interviews, and documentation. Based on the research results, several things can be improved for more efficiency and effectiveness in archiving 1) What can be improved is the system currently used. Pelindo IV (Persero) Balikpapan Branch, namely the system regarding this is quite good, it's just that in recovering it is still difficult to find because letters are in other classification sections such as payment archives in the information system classification. 2) Tools and equipment used in managing archives are wooden and glass cabinets. The arrangement is still disorganized because the order folders are just piled up. The archive storage space is too small so many archives accumulate and cannot be put in the cupboard. 3) There are still many archives whose duration of archive destruction is too long, considering the number of incoming documents or document production is quite high and quite a lot because archives that are old and no longer needed will be destroyed within a yearly period.
Keteladanan Kepemimpinan Hamba Tuhan Upaya Penerapan Kesadaran Pentingnya Beribadah
Authors: Juindri Ekinaldi
Published: May 2023

Exemplary leadership of God's servants in carrying out efforts to raise awareness of the importance of worship. This is very important for society. Provide more understanding and exemplary than God's servant who can influence or make an exemplary example that reflects the basic ministry of Jesus the Messiah who is an example. In this study, there is a symptom that causes church members not to consider worship as important in building public awareness to prioritize worship with the aim of each working and glorifying God in worship. The presence of God's servant in the organization to perform ministry. Services that are carried out humbly can encourage the congregation to pray and provide an understanding of the importance of worship which will change the pattern of life that God really wants.
Eksposisi Gambar Allah Menurut Penciptaan Manusia Berdasarkan Kejadian 1:26-28
Authors: Filemon Filemon
Published: May 2023

The purpose of human creation based on the context of Genesis 1:26-28 is that humans were created to relate to other creatures and also to fellow human beings where God wants humans to be fruitful and multiply to fill the earth. Allah created man to fulfill His plan and all His creations belong to Him. The image of God in man reflects the personality of God before man fell into sin. And humans who were created in God's image have the responsibility to subdue all of His creation as a responsibility for God's sovereignty as His representative on earth.
ANALISIS DAN PERANCANGAN SISTEM INFORMASI PENGUPAHAN KARYAWAN OUTSOURCING
Authors: Zafir Ibrahim  , Rifky Aswin
Published: May 2023

PT.Trimegah Cipta Mandiri yang beralamat di Jl.Singa Tengah II Kav. 21-22 adalah suatu perusahaan yang bergerak di bidang jasa yaitu alih daya atau yang dikenal dengan istilah outsourcing. Perusahaan tersebut bahwa selama ini untuk pemasaran masih menggunakan telpon, media cetak dan datang langsung ke perusahaan calon relasi kerja sehingga tidak bisa mengetahui informasi tentang PT.Trimegah Cipta Mandiri dengan lengkap dan up to date dan membutuhkan waktu cukup lama dan biaya cukup banyak . Disamping itu pada saat relasi kerja membutuhkan calon tenaga kerja baru mengalami kesulitan, karena tidak mengetahui secara langsung data tentang calon tenaga kerja baru dan lokasi relasi kerja yang berada diluar kota antara lain Salatiga, Temanggung, Kendal sehingga informasi yang didapat dirasa kurang oleh relasi kerja.
Pengembangan Media Pembelajaran Interaktif Berbasis Web Menggunakan Google Sites untuk Meningkatkan Prestasi Belajar Siswa
Authors: Prayudi Andi , Anggriani Aan Ayu
Published: May 2023

Telah dilakukan penelitian dengan mengembangkan media pembelajaran interaktif berbasis web di SMK IT O’o Dompu menggunakan Google sites  dengan tujuan mempermudah penyampaian materi teknologi jaringan berbasis WAN. Data dianalisis secara deskriptif kuantitatif-kualitatif dengan hasil: ahli media dan materi memperoleh persentase kelayakan 90%, respon siswa 93%, soal pre test 50%, dan soal post test 97%.dilihat dari hasil analisis data media pembelajaran interaktif berbasis web dikatakan layak dengan perolehan skor valid,efektif,dan praktis memenuhi nilai kelayakan. Simpulan penelitian ini adalah media pembelajaran interaktif berbasis video untuk meningkatkan prestasi belajar siswa yang dibuat menggunakan Google sites  layak digunakan sebagai alat bantu dalam mengajar.
Pengembangan Video Animasi Pembelajaran Komputer dan Jaringan Dasar pada Kompetensi Keahlian Multimedia
Authors: Nugraha Ary Fauzy , Burhanuddin  , Prayudi Andi
Published: May 2023

Animasi merupakan sekumpulan gambar yang disusun secara berurutan. Ketika rangkaian gambar tersebut di tampilkan dengan kecepatan yang memadai, maka rangkaian gambar tersebut akan terlihat bergerak. penenliti ini bertujuan membuat produk media video animasi pembelajaran pada mata pelajaran komputer dan jaringan dasar karena tidak adanya media video animasi pada pelajaran tersebut. Media pembelajaran video animasi ini akan menjadi suatu media pembelajaran alternatif media yang menarik bagi siswa saat dalam pembelajaran di kelas serta relatif mudah dalam penyampaianya. Setelah melakukan beberapa tahapan penilaian pada pengembangan dan perancangan media video animasi pembelajaran yang telah dikembangkan selanjutnya akan diterapkan pada sasaran yang sebenarnya. Setalah proses pembuatan produk dan kemudian produk yang dikembangkan akan divalidasi oleh 2 ahli yang terdiri dari ahli materi mendapatkan 76% dan ahli media pembelajaran sebesar 74%. Media video animasi pembelajaran diuji kepada siswa yang telah ditetapkan pada sampel penelitian. Data yang akan dikumpulkan pada tahap ini yaitu terkait dengan tingkat kepraktisan media pembelajaran melalui angket respon siswa, dan tingkat efektivitas melalalui tets pretest dan tes Postets. Berikut disajikan hasil implementasi media pembelajaran berbasis video. Kepraktisan media pembelajaran mendapatkan persentase sebesar 86% sedangkan efektifitas meningkat sebesar 20%.
Kinetic and equilibrium study of arsenic sorption on silanized magnetic amino-functionalized nanocomposite
Authors: Surčić Ljiljana , Tadić Tamara , Nastasović Aleksandra , Marković Bojana , Onjia Antonije
Published: May 2023

Arsenic is a metalloid, which occurs in nature in various forms, but in natural waters mainly in the form of pentavalent oxyanion of arsenate As(V) and trivalent arsenite As(III), which dominates under anaerobic conditions. Arsenic water pollution is a serious problem due to its pronounced negative impact on human health. This paper describes the kinetic and equilibrium studies of the sorption mechanism of oxyanion As(V) in monocomponent aqueous solutions on a silanized magnetic amino-functionalized copolymer of glycidyl methacrylate and ethylene glycol dimethacrylate m-Si-PGME-deta. It has been shown that the sorption of As(V) on m-Si-PGME-deta is a rapid process, initially controlled by ion diffusion rate through solution. After achieving the saturation of the sorbent surface, the sorption rate decreases, because the sorption rate determines the process of intraparticle pore diffusion. The maximum sorption capacity is 5.61 μmolˑg-1.
Methylene blue removal by adsorption on unmodified and modified wood sawdust
Authors: Drljača Dijana , Borković Aleksandra , Dragić Dajana , Botić Tatjana , Mićanović Violeta , Popović Goran , Vukić Ljiljana , Dugić Pero
Published: May 2023

Adsorption, as an easy and effective technique, is widely used to remove a large number of dyes from aqueous solutions. Activated carbon is the most desirable adsorbent, but due to its high cost, its use is limited. Proving the possibility of adsorption and its efficiency performed on cheap adsorbents is a great challenge and interest of many researchers in the past few decades. In this paper, unmodified (P) and modified sawdust obtained in two ways (HCl treatment and NaOH treatment), labeled as PHCl and PNaOH, are used for the removal of the methylene blue dye. Adsorption experiments showed that the optimal time for adsorption is different, for the sample PNaOH – 30 min, for the sample P – 45 min, and for the sample PHCl – 60 min. By applying nonlinear kinetic models to the experimentally obtained data, it was found that the best model that describes this adsorption is pseudo-second-order model. By examining the effect of pH values on adsorption, different results were obtained (for samples P and PHCl the optimal pH value is pH=11, the PNaOH sample is effective in a wider range of pH values). The analysis of the effect adsorbent dose on adsorption process showed that the efficiency of dye removal decreases with increasing mass of adsorbents. The obtained values of the coefficient of determination in Freundlich's model for samples of unmodified (P) and modified sawdust (PNaOH) indicate that the adsorption of the methylene blue dye is multilayer type adsorption. For the PHCl sample, neither the Langmuir nor Freundlich model adequately described MB dye adsorption.
Quantum correlation between spin and motion in quantum chromodynamics matter
Authors: Yin Yi ,   Quark Matter Research Center, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
Published: May 2023

Recently, the \begin{document}$\Lambda$\end{document} polarization has been observed at relativistic heavy-ion collider (RHIC) and large hadron collider (LHC). This observation has inspired many studies on spin dynamics of quantum chromodynamics (QCD) many-body physics, thus opening a new avenue to studying the hot and dense nuclear matter.This paper reviews the recent progress of spin effects in relativistic heavy-ion collisions, with an emphasis on the quantum correlation between spin and motion in QCD matter, including newly discovered shear-induced polarization (SIP), a novel effect that fluid shear polarizes the spin. The linear response theory’s applications to studying those effects are also systematically reviewed. Finally, their observational signatures in experiments are discussed.
APOE expression and secretion are modulated by mitochondrial dysfunction
Authors: Wynne Meghan E , Ogunbona Oluwaseun , Lane Alicia R , Gokhale Avanti , Zlatic Stephanie A , Xu Chongchong , Wen Zhexing , Duong Duc M , Rayaprolu Sruti , Ivanova Anna , Ortlund Eric A , Dammer Eric B , Seyfried Nicholas T , Roberts Blaine R , Crocker Amanda , Shanbhag Vinit , Petris Michael , Senoo Nanami , Kandasamy Selvaraju , Claypool Steven Michael , Barrientos Antoni , Wingo Aliza , Wingo Thomas S , Rangaraju Srikant , Levey Allan I , Werner Erica , Faundez Victor
Published: May 2023

Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more extensive than previously appreciated, as both genetic and pharmacological disruption of the electron transport chain caused upregulation of the Alzheimer’s disease risk factor apolipoprotein E (APOE) and other secretome components. Indirect disruption of the electron transport chain by gene editing of SLC25A mitochondrial membrane transporters as well as direct genetic and pharmacological disruption of either complexes I, III, or the copper-containing complex IV of the electron transport chain elicited upregulation of APOE transcript, protein, and secretion, up to 49-fold. These APOE phenotypes were robustly expressed in diverse cell types and iPSC-derived human astrocytes as part of an inflammatory gene expression program. Moreover, age- and genotype-dependent decline in brain levels of respiratory complex I preceded an increase in APOE in the 5xFAD mouse model. We propose that mitochondria act as novel upstream regulators of APOE-dependent cellular processes in health and disease.
A robust cooperative localization algorithm based on covariance intersection method for multi-robot systems
Authors: Wang Miao , Liu Qingshan
Published: May 2023

Cooperative localization is an arising research problem for multi-robot system, especially for the scenarios that need to reduce the communication load of base stations. This article proposes a novel cooperative localization algorithm, which can achieve high accuracy localization by using the relative measurements among robots. To address uncertainty in the measuring robots’ positions and avoid linearization errors in the extended Kalman filter during the measurement update phase, a particle-based approximation method is proposed. The covariance intersection method is then employed to fuse preliminary estimations from different robots, guaranteeing a minimum upper bound for the fused covariance. Moreover, in order to avoid the negative effect of abnormal measurements, this article adopts the Kullback–Leibler divergence to calculate the distances between different estimations and rejects to fuse the preliminary estimations far from the estimation obtained in the prediction stage. Two simulations are conducted to validate the proposed algorithm. Compared with the other three algorithms, the proposed algorithm can achieve higher localization accuracy and deal with the abnormal measurement.
SEMGROMI—a semantic grouping algorithm to identifying microservices using semantic similarity of user stories
Authors: Vera-Rivera Fredy H. , Puerto Cuadros Eduard Gilberto , Perez Boris , Astudillo Hernán , Gaona Carlos
Published: May 2023

Microservices is an architectural style for service-oriented distributed computing, and is being widely adopted in several domains, including autonomous vehicles, sensor networks, IoT systems, energy systems, telecommunications networks and telemedicine systems. When migrating a monolithic system to a microservices architecture, one of the key design problems is the “microservice granularity definition”,i.e., deciding how many microservices are needed and allocating computations among them. This article describes a semantic grouping algorithm (SEMGROMI), a technique that takes user stories, a well-known functional requirements specification technique, and identifies number and scope of candidate microservices using semantic similarity of the user stories’ textual description, while optimizing for low coupling, high cohesion, and high semantic similarity. Using the technique in four validation projects (two state-of-the-art projects and two industry projects), the proposed technique was compared with domain-driven design (DDD), the most frequent method used to identify microservices, and with a genetic algorithm previously proposed as part of the Microservices Backlog model. We found that SEMGROMI yields decompositions of user stories to microservices with high cohesion (from the semantic point of view) and low coupling, the complexity was reduced, also the communication between microservices and the estimated development time was decreased. Therefore, SEMGROMI is a viable option for the design and evaluation of microservices-based applications. The proposed semantic similarity-based technique (SEMGROMI) is part of the Microservices Backlog model, which allows to evaluate candidate microservices graphically and based on metrics to make design-time decisions about the architecture of the microservices-based application.
Urinary aluminium and its association with autism spectrum disorder in urban preschool children in Malaysia
Authors: Abd Wahil Mohd Shahrol , Ja’afar Mohd Hasni , Md Isa Zaleha
Published: May 2023

Background

The presence of aluminium (Al) in the human body may impact brain neurodevelopment and function, and it is thought to contribute to autism spectrum disease (ASD). The main objective of this study was to assess the association between urinary Al and the development of ASD among Malaysian preschool children in the urban city of Kuala Lumpur.

Method

This was an unmatched case–control study in which children with ASD were recruited from an autism early intervention center and typically developed (TD) children were recruited from government-run nurseries and preschools. Urine samples were collected at home, assembled temporarily at study locations, and transported to the laboratory within 24 h. The Al concentration in the children’s urine samples was determined using inductively coupled plasma mass spectrometry (ICP-MS).

Result

A total of 155 preschool children; 81 ASD children and 74 TD children, aged 3 to 6 years, were enlisted in the study. This study demonstrated that ASD children had significantly higher urinary Al levels than TD children (median (interquartile range (IQR): 2.89 (6.77) µg/dL versus 0.96 (2.95) µg/dL) (p < 0.001). Higher parental education level, non-Malay ethnicity, male gender, and higher urinary Al level were the significant ASD risk factors (adjusted odds ratio (aOR) >1, p < 0.05).

Conclusion

A higher urine Al level was discovered to be a significant risk factor for ASD among preschool children in the urban area of Kuala Lumpur, Malaysia.
Marketing de relacionamento e retenção de clientes: um estudo sobre aspectos influenciadores na fidelização dos clientes no comércio varejista
Authors: Gomes Thiago Eliandro de Oliveira , Almada Vitor Rodrigues , Almirão Darlen de Oliveira , Rizzatti Émerson Oliveira
Published: May 2023

O marketing de relacionamento está diretamente ligado às estratégias de retenção de clientes, pois busca um relacionamento duradouro entre a empresa e seus consumidores por meio do compromisso de entrega de valor. Este artigo propõe identificar os principais atributos do marketing de relacionamento que influenciam na decisão de compra e manutenção dos clientes no comércio varejista de Alegrete, RS. Utilizou-se a abordagem exploratório-descritiva, dividida em etapa qualitativa com aplicação da técnica do incidente crítico, gerada por relatos de experiências positivas e negativas vividas pelo entrevistado. Na etapa quantitativa, foi aplicado um questionário estruturado a 407 clientes, utilizando-se a análise de correlação entre incidentes críticos. Os resultados sugerem que o principal atributo para a retenção de clientes é o atendimento ao cliente. Itens como atendimento, simpatia e atenção se destacaram em ambas as etapas da pesquisa quando relacionados à necessidade de atendimento. Houve correlação entre a idade e a renda dos entrevistados quanto à preferência por itens de tecnologia como site da loja, e-commerce e aplicativos. O público jovem e de alta renda tende a fazer compras online. Conclui-se que é necessário que o comércio de Alegrete se modernize, adote novas tecnologias e busque soluções para satisfazer e reter os clientes.
Impacto de la inversión extranjera directa sobre el desarrollo económico en Sinaloa entre 2015-2020
Authors: Gastélum Rosalinda Gámez , Medina Juan Carlos Meléndrez
Published: May 2023

La IED es una variable que genera impactos positivos en las regiones donde se instala, debido a los efectos directos e indirectos que tiene sobre la economía local, generando un incremento en el desarrollo económico local en última instancia. Sin embargo, es un hecho que esto no siempre será así y, dependerá de las capacidades de cada región, tanto para absorber los efectos positivos esparcidos en su economía por parte de las empresas extranjeras, como para regular las acciones de las mismas. El presente trabajo de investigación se enfoca en describir el impacto que ha tenido la IED sobre el desarrollo económico de una región específica, el estado de Sinaloa, entre los años 2015 y 2020, con el objetivo de aportar información nueva para el beneficio de la entidad.
Evaluation of Sugarcane (Saccharum spp. hybrids) Clones for Yield and Quality and Its Contributing Traits
Authors: Ganapathy S. , Jayakumar J.
Published: May 2023

Evaluation and identification of varieties for different agro-climatic condition is of prime importance in sugarcane cultivation for farmers. The present investigation was undertaken with the objective of evaluation of sugarcane clones for yield and quality and its contributing traits. The Experimental materials consist of five test clones viz., CoA 13322, CoA 13323, CoC 13336, CoC 13337 and CoV 13356 and two standard checks (CoC 01061 and CoA 92081). Observations were recorded for germination per cent (%), number of tillers (x1000/ha), number of millable cane (x1000/ha), cane length (cm), Cane diameter (cm), Single cane weight (kg), cane yield (t/ha), brix (%), Purity (%), sucrose (%), CCS (%) and CCS yield (t/ha). Based on the results of the different clones for different traits evaluated, the clone CoC 13336 was found the best performing clone in respect of cane yield (140.71 t/ha), CCS yield (18.23 t/ha) and other important traits over the standards (checks). The clone CoC 13337 was the next best performing clone for cane yield (139.92 t/ha), CCS yield (17.93 t/ha) and other traits over the standards and these two clones may be promoted for further evaluation trial for the release new sugarcane variety suitable for early season of Tamil Nadu.
Health Care Use and Spending Among Need-Based Subgroups of Medicare Beneficiaries With Full Medicaid Benefits
Authors: Kaufman Brystana G. , Jones Kelley A. , Greiner Melissa A. , Giri Abhigya , Stewart Lucas , He Amanda , Clark Amy G. , Taylor Donald H. , Bundorf M. Kate , Whitaker Rebecca G. , Van Houtven Courtney H. , Higgins Aparna
Published: May 2023

Importance

Beneficiaries dual eligible for Medicare and Medicaid account for a disproportionate share of expenditures due to their complex care needs. Lack of coordination between payment programs creates misaligned incentives, resulting in higher costs, fragmented care, and poor health outcomes.

Objective

To inform the design of integrated programs by describing the health care use and spending for need-based subgroups in North Carolina’s full benefit, dual-eligible population.

Design, Setting, and Participants

This cross-sectional study using Medicare and North Carolina Medicaid 100% claims data (2014-2017) linked at the individual level included Medicare beneficiaries with full North Carolina Medicaid benefits. Data were analyzed between 2021 and 2022.

Exposure

Need-based subgroups: community well, home- and community-based services (HCBS) users, nursing home (NH) residents, and intensive behavioral health (BH) users.

Measures

Medicare and Medicaid utilization and spending per person-year (PPY).

Results

The cohort (n = 333 240) comprised subgroups of community well (64.1%, n = 213 667), HCBS users (15.0%, n = 50 095), BH users (15.2%, n = 50 509), and NH residents (7.5%, n = 24 927). Overall, 61.1% reported female sex. The most common racial identities included Asian (1.8%), Black (36.1%), and White (58.7%). Combined spending for Medicare and Medicaid was $26 874 PPY, and the funding of care was split evenly between Medicare and Medicaid. Among need-based subgroups, combined spending was lowest among community well at $19 734 PPY with the lowest portion (38.5%) of spending contributed by Medicaid ($7605). Among NH residents, overall spending ($68 359) was highest, and the highest portion of spending contributed by Medicaid (70.1%). Key components of spending among HCBS users’ combined total of $40 069 PPY were clinician services on carrier claims ($14 523) and outpatient facility services ($9012).

Conclusions and relevance

Federal and state policy makers and administrators are developing strategies to integrate Medicare- and Medicaid-funded health care services to provide better care to the people enrolled in both programs. Substantial use of both Medicare- and Medicaid-funded services was found across all need-based subgroups, and the services contributing a high proportion of the total spending differed across subgroups. The diversity of health care use suggests a tailored approach to integration strategies with comprehensive set benefits that comprises Medicare and Medicaid services, including long-term services and supports, BH, palliative care, and social services.
Pancreatic cancer‐derived small extracellular vesical ezrin activates fibroblasts to exacerbate cancer metastasis through STAT3 and YAP‐1 signaling pathways
Authors: Chang Yu‐Ting , Peng Hsuan‐Yu , Hu Chun‐Mei , Tien Sui‐Chih , Chen Yi‐Ing , Jeng Yung‐Ming , Chang Ming‐Chu
Published: May 2023

Cancer‐associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC), play an important role in tumorigenesis, metastasis, and chemoresistance. Tumor‐derived small extracellular vesicles (sEVs), which mediate cell‐to‐cell communication between cancer cells and fibroblasts, are also critical for cancer progression and metastasis. However, it remains unclear how PDAC cell‐derived sEVs activate fibroblasts, which contributes to tumor progression. Here, we report that ezrin (EZR) expression in PDAC cell‐derived sEVs (sEV‐EZR) can activate fibroblasts, resulting in increased migration ability and high expression of α‐SMA, PDGFRB, and high production of extracellular matrix in fibroblasts. Reciprocally, sEV‐EZR‐activated fibroblasts enhanced PDAC cell proliferation, invasion, and metastasis to the liver in animal models. Conversely, fibroblasts treated with PDAC cell‐derived sEVs with EZR knockdown resulted in the reduced metastatic ability of PDAC. Mechanistically, we demonstrated that PDAC cell‐derived sEV‐EZR increases the STAT3 and YAP‐1 signaling pathways to induce fibroblast activation, and the activated fibroblasts promote PDAC cell proliferation, invasion, and liver metastasis. Inhibition of the STAT3 and YAP‐1 signaling pathways by gene knockdown can abrogate sEV‐EZR‐induced effects. These findings suggest that targeting the interaction between PDAC cell‐derived sEV‐EZR and fibroblasts is a potential therapeutic strategy for PDAC.
Controllable Bubble Transport on Bioinspired Heteromorphic Magnetically Steerable Microcilia
Authors: Wang Yan , Zhang Liwen , Du Wenxin , Zhou Xinzhao , Guo Yurun , Zhao Song , Liu Guang , Zhang Deyuan , Chen Huawei
Published: May 2023

Controllable transport of underwater gas bubbles is essential in various fields such as gas energy, drug delivery, and heat transfer. Although anisotropic structures are used to transport bubbles, their motion direction can only be adjusted to a limited extent because of weak structural anisotropy and small responsive deformation. Here, anisotropic bubble transport is found on microcilia surfaces of diving beetle's elytra with regular inclination and heteromorphic structure of microcilia, which have hooked tips and crescent‐shaped roots. Inspired by these, a magnetically steerable microcilia surface with large‐range inclination adjustment is proposed for highly controllable bubble transport via a heterogeneous configuration strategy. The dynamic in situ microscopic behavior shows a novel shifting phenomenon of the maximum bubble pinning position from bubble back interface for hydrophobic cilia to front interface for hydrophilic cilia under different cilium wettabilities. This shift varies the bubble shapes from unstable stretching to stable compression, thus increasing the difference in anisotropic transport by three times for hydrophilic cilia. Moreover, bioinspired heteromorphic structures can further enhance such difference by 5.5 times. Based on the proposed theory, several smart functional microcilia are designed to achieve more complex bubble manipulation, thus improving their suitability for widespread application.
Organic Electronic Platform for Real‐Time Phenotypic Screening of Extracellular‐Vesicle‐Driven Breast Cancer Metastasis
Authors: Traberg Walther C. , Uribe Johana , Druet Victor , Hama Adel , Moysidou Chrysanthi‐Maria , Huerta Miriam , McCoy Reece , Hayward Daniel , Savva Achilleas , Genovese Amaury M. R. , Pavagada Suraj , Lu Zixuan , Koklu Anil , Pappa Anna‐Maria , Fitzgerald Rebecca , Inal Sahika , Daniel Susan , Owens Róisín M.
Published: May 2023

Tumor‐derived extracellular vesicles (TEVs) induce the epithelial‐to‐mesenchymal transition (EMT) in nonmalignant cells to promote invasion and cancer metastasis, representing a novel therapeutic target in a field severely lacking in efficacious antimetastasis treatments. However, scalable technologies that allow continuous, multiparametric monitoring for identifying metastasis inhibitors are absent. Here, the development of a functional phenotypic screening platform based on organic electrochemical transistors (OECTs) for real‐time, noninvasive monitoring of TEV‐induced EMT and screening of antimetastatic drugs is reported. TEVs derived from the triple‐negative breast cancer cell line MDA‐MB‐231 induce EMT in nonmalignant breast epithelial cells (MCF10A) over a nine‐day period, recapitulating a model of invasive ductal carcinoma metastasis. Immunoblot analysis and immunofluorescence imaging confirm the EMT status of TEV‐treated cells, while dual optical and electrical readouts of cell phenotype are obtained using OECTs. Further, heparin, a competitive inhibitor of cell surface receptors, is identified as an effective blocker of TEV‐induced EMT. Together, these results demonstrate the utility of the platform for TEV‐targeted drug discovery, allowing for facile modeling of the transient drug response using electrical measurements, and provide proof of concept that inhibitors of TEV function have potential as antimetastatic drug candidates.
Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency
Authors: Cheng Miffy Hok Yan , Leung Jerry , Zhang Yao , Strong Colton , Basha Genc , Momeni Arash , Chen Yihang , Jan Eric , Abdolahzadeh Amir , Wang Xinying , Kulkarni Jayesh A. , Witzigmann Dominik , Cullis Pieter R.
Published: May 2023

The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic lipid component. LNP mRNA systems composed of optimized ionizable lipids often display distinctive mRNA‐rich “bleb” structures. Here, it is shown that such structures can also be induced for LNPs containing nominally less active ionizable lipids by formulating them in the presence of high concentrations of pH 4 buffers such as sodium citrate, leading to improved transfection potencies both in vitro and in vivo. Induction of bleb structure and improved potency is dependent on the type of pH 4 buffer employed, with LNP mRNA systems prepared using 300 mm sodium citrate buffer displaying maximum transfection. The improved transfection potencies of LNP mRNA systems displaying bleb structure can be attributed, at least in part, to enhanced integrity of the encapsulated mRNA. It is concluded that enhanced transfection can be achieved by optimizing formulation parameters to improve mRNA stability and that optimization of ionizable lipids to achieve enhanced potency may well lead to improvements in mRNA integrity through formation of the bleb structure rather than enhanced intracellular delivery.
Highly Integrated Multifunctional Coding Metasurface in Full‐Space Based on Independent Control of Transmission and Reflection
Authors: Xu Peng , Liu Haixia , Li Ruijie , Han Jiaqi , Chen Silong , Li Long
Published: May 2023

Multifunctional metasurfaces working in the transmission‐reflection (TR) state have attracted more attention because the TR metasurface integrating more functionalities saves the occupied space and further expands the control abilities of electromagnetic waves in full space. Herein, a switchable TR coding metasurface is proposed that can not only dynamically regulate the TR states of the x/y polarizations but also realize the independent phase control of the transmitted and reflected x/y polarizations. Subsequently, based on different polarizations control, as the first proof‐of‐concept demonstration, a multifunctional coding metasurface, including the dual‐beam deflection, beam focusing, and vortex beam generation, is demonstrated numerically, theoretically, and experimentally. Meanwhile, as the second proof‐of‐concept demonstration, a switchable multi‐beam metasurface, including dynamic TR amplitude coding, phase coding, and beam‐scanning for both x and y polarizations in full space, is verified numerically and experimentally. Therefore, the proposed highly integrated multifunctional coding metasurface provides a promising way to integrate multifunction and enables full‐space wireless communication.
Metal‐Free Electrochemical Hydroboration of Olefins
Authors: Yuan Qilin , Zhang Xiao , Guo Lin , Yang Chao , Xia Wujiong
Published: May 2023

Herein, we reported the electrochemical hydroboration of olefins to access the organoboron derivatives in a one‐pot reaction under air and at room temperature. This reaction manifold was applied to a broad range of alkenes with 40–90% yields and good functional group tolerance without using a metal catalyst or an additional hydride source. Mechanistic studies suggested that this anodic oxidation conducted in an undivided cell allowing the production of a boron radical species, which initiates the hydroboration of olefins event by a radical addition process.
XO2 (X = Pd, Pt) Monolayers: A Promising Thermoelectric Materials
Authors: Wani Aadil Fayaz , Patra Lokanath , Srinivasan Marutheeswaran , Singh Jaspal , Abdelmohsen Shaimaa A. M. , Alanazi Meznah M. , Dhiman Shobhna , Kaur Kulwinder
Published: May 2023

In this work, the structural, thermoelectric, and electronic properties of XO2 (X = Pd, Pt) monolayers are investigated using density functional approach and Boltzmann transport equations (BTE). These materials are semiconductor in nature having indirect band gap 1.40 (1.69 eV) for PdO2 (PtO2) monolayers. These materials are chemically as well as dynamical stable. The observation of a sharp peak in the vicinity of the Fermi level indicates a high value of the Seebeck coefficient (S). The calculated value of S is 2269 (2734) µV K−1 with respect to n (p)‐type doping at carrier concentration of 1.12 (2.33) × 1013 cm−2 for PdO2 (PtO2) monolayer at 300 K. Calculations reveal a lattice thermal conductivity (κl) of 15.85 and 12.41 Wm−1K−1 for PdO2 and PtO2 monolayers, respectively at room temperature. Monolayer PtO2 shows a larger S and smaller k as compared to PdO2. Due to the maximum value of power factor and minimum value of lattice thermal conductivity, ZT for n‐type doped PtO2 monolayer (1.04) is higher than PdO2 monolayers (0.87). The findings provide a blueprint for evaluating the thermal energy conversion efficiency of XO2 monolayers for potential thermoelectric applications.
m6A‐Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis
Authors: Yang Xia , Bai Qiaorui , Chen Weizhong , Liang Jiaer , Wang Fang , Gu Weiqi , Liu Lei , Li Quanfeng , Chen Zishuo , Zhou Anni , Long Jianting , Tian Han , Wu Jueheng , Ding Xiaofan , Zhou Ningning , Li Mengfeng , Yang Yi , Cai Junchao
Published: May 2023

The importance of mRNA N6‐methyladenosine (m6A) modification during tumor metastasis is controversial as it plays distinct roles in different biological contexts. Moreover, how cancer cell plasticity is shaped by m6A modification is interesting but remains uncharacterized. Here, this work shows that m6A reader insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) is remarkably upregulated in metastatic lung adenocarcinoma (LUAD) and indicates worse prognosis of patients. Interestingly, IGF2BP3 induces partial epithelial‐mesenchymal‐transition (EMT) and confers LUAD cells plasticity to metastasize through m6A‐dependent overactivation of Notch signaling. Mechanistically, IGF2BP3 recognized m6A‐modified minichromosome maintenance complex component (MCM5) mRNAs to prolong stability of them, subsequently upregulating MCM5 protein, which competitively inhibits SIRT1‐mediated deacetylation of Notch1 intracellular domain (NICD1), stabilizes NICD1 protein and contributes to m6A‐dependent IGF2BP3‐mediated cellular plasticity. Notably, a tight correlation of the IGF2BP3/MCM5/Notch axis is evidenced in clinical LUAD specimens. Therefore, this study elucidates a critical role of m6A modification on LUAD cell plasticity in fostering tumor metastasis via the above axis, providing potential targets for metastatic LUAD.