bluuebunny/crossref_metadata_2025 huggingface dataset:
Charting the Course for Bureaucratic Reform: The Path to Progress in Purwakarta Regency
Authors: Satibi Iwan
Published: August 2024

The policy of preparing a bureaucratic reform road map for the Government of Purwakarta Regency is a strategic decision in line with the strengthening demands and needs of the community. The presence of an institutional bureaucratic reform road map has provided an opportunity for regional governments, including the Purwakarta Regency Government, to ensure the creation of improved governance. Comprehensively, the focus of changes in bureaucratic reform within the Purwakarta Regency Government includes 8 areas of bureaucratic reform, namely apparatus mentality, supervision, accountability, governance institutions, human resources for the state civil apparatus, laws and regulations, and public services. The results of the study found that in order to improve the quality of the policy road map for bureaucratic reform to be designed, there are three main things that must be updated, including; first, the road map for bureaucratic reform must project more on matters that are implementative in nature rather than matters that are merely formalities. Second, programs and activities that are designed must be realistic, so that they can be implemented up to work units. Third, policy analysis related to governance must be carried out in a more holistic, comprehensive and anticipatory manner so as to be able to capture real progress, challenges and problems of bureaucratic reform.
Implementation of Indonesia's Sea Defense Strategy Policy In Facing Military Threats to Support Sea Power
Authors: Putri Puja Sari , Ansori Ansori , Syifaranie S. Reghina R. , Nurlaily Anis , Jati Hafidz K.
Published: August 2024

Indonesia in realizing the World Maritime Axis country requires good physical and mental conditions where all elements greatly affect the performance and performance of the country in carrying out defense and security in order to achieve national goals. This article uses a qualitative method. Regarding the Implementation of the Archipelago Sea Defense Strategy Policy in Facing Military Threats to Support Sea Power. Using the theory of policy implementation according to Edward III, namely Communication, Resources, Disposition and Bureaucratic Structure. To obtain data using the Library Research method, which includes the use of books, scientific journals, trade publications, magazines, newspapers, the internet, and artifacts. That when viewed based on Edward III's first policy implementation theory of communication that good communication will bring Indonesia into defense diplomatically with the country concerned without having to go to war, disposition requires Indonesia to take an active role in collective security efforts in the ASEAN Regional region so as to create decisions that can be mutually agreed upon in cases of territorial waters or state borders in the ASEAN Regional region, resources require Indonesia to understand the current threat spectrum that the glass of power of great power countries has occurred in the region so that the government must take the right steps in fulfilling both human resources and defense equipment, and finally the bureaucratic structure where all elements responsible for marine security must take part in maintaining marine security and defense and minimizing the egocentricity of each institution in order to achieve national goals
Kampanye Catcalling Pada Perempuan Di Media Sosial
Authors: Nurfudiniyah  , Hakim Lukman
Published: August 2024

Sexual harassment is an issue that has long been a social problem, especially in Indonesia. The number of sexual harassment cases is increasing every year and most of them are dominated by verbal sexual harassment such as catcalling. One of the social media that campaigns for the issue of catcalling is the Instagram account @dearcatcallers.id. This study discusses how the catcalling campaign for women on the Instagram account @dearcatcallerd.id. This study aims to find out the discourse behind the @dearcatcallers.id campaign content using Norman Fairclough's Critical Discourse Analysis. This study resulted in the finding that @dearcatcallers.id created and shared its content in response to harassment events that occurred in the form of survivor narratives or videos from third parties, not in the form of content that was intentionally made about catcalling. The story is rewritten or disseminated by emphasizing several meanings so that the essence of catcalling can be accepted by netizens. For example, making Bold Style writing, using exclamation points, emoticons, everyday language, and terms that have positive connotations.
Pengaruh Komunikasi Visual Desain Grafis Buku Mizan Terhadap Minat Baca Anak
Authors: Chairiyah Ummy , Achmad Fandi
Published: August 2024

Children's books that use graphic design are currently in great demand by children. Mizan Publisher has published a book that utilizes the concept of graphic design as a way to attract children's reading interest. Graphic design elements in children's books are the key to successful persuasion.This study aims to measure the extent to which graphic design as a propaganda medium affects reading interest. The research uses a quantitative method through parametric statistics with a Likert scale. The correlation analysis is examined by using simple linear regression analysis, Pearson correlation test,  and coefficient of determination test. Based on the simple regression test the result has revealed that the value of r = 0.767 and has a coefficient of determination of 17.7%. Which shows that there is a positive and very strong relationship between the influence of visual communication on graphic design of Mizan's book on reading interest by 17.7%.
Jurnalisme Kampus: Sistem Penugasan Dan Pola Komunikasi Pers Mahasiswa UINSA Surabaya
Authors: Emeraldien Fikry Zahria , Nurhayati Alfina , Rotuzzakia Choe , Rofi' M. Ianur
Published: August 2024

The existence of a student press institution at a university, through which the students can enhance their creativity with regard to journalism as well as a laboratory for students of the department of communication and broadcast, is pivotal. UIN Sunan Ampel Surabaya has campus press and broadcasting institutions, such as campus television, radio, tabloids, and bulletins. This research seeks to examine the communication patterns of journalists and the professionalism of the assignment system within the student press institution at UIN Sunan Ampel Surabaya. Using an ethnographic approach, this study has found that there are similarities in the news production system of student press with professional press institutions. Meanwhile, the communication pattern of the student press organization is multi-directional with a strong sense of brotherhood
Strengthening of simply supported deep beams with openings using steel-reinforced ECC and externally bonded CFRP sheets
Authors: Hamoda Ahmed , Yehia Saad A. , Abadel Aref A. , Sennah Khaled , Shahin Ramy I.
Published: August 2024

In many practical applications, openings in deep beams are essential for accommodating services like ducts, pipes and cables. However, openings can significantly disrupt the load-transfer mechanism and reduce the shear strength of the beam, potentially leading to premature failure. Strengthening techniques are thus used to restore or enhance the load-carrying capacity and structural performance of deep beams with openings. The effectiveness of a novel strengthening approach that combines reinforced engineered cementitious composites (ECCs) and externally bonded carbon-fibre-reinforced polymer (CFRP) sheets was investigated. ECC reinforced with galvanised steel wire mesh was applied to the beam sides, with steel anchors to connect it to the concrete. CFRP sheets were then glued onto the hardened ECC surface. ECCs are highly ductile, fibre-reinforced cementitious materials with superior crack resistance and energy dissipation capabilities. Externally bonded CFRP sheets provide additional shear reinforcement and confinement owing to their high tensile strength. Six reinforced concrete deep beam specimens were fabricated and tested to investigate the effects of opening shape (rectangular or circular) and size on shear capacity. Load–deflection responses, crack patterns and failure modes were obtained. A non-linear finite-element model, developed to simulate the strengthening technique, was validated using the experimental findings. The results of this work provide valuable guidelines for enhancing the performance of deep beams with openings using reinforced ECCs and externally bonded CFRP sheets.
Prediction of ultimate bearing capacity of RC beams after fire: data-driven method
Authors: Liu Chaofeng , Liu Qianqian , Zhang En , Zhao Yan , Wang Ling , Liu Caiwei
Published: August 2024

The ultimate bearing capacity of reinforced concrete (RC) beams after exposure to fire was investigated using numerical simulations, regression fitting and machine learning techniques to examine the thermal and mechanical properties of the beams after high-temperature exposure. A series of fire and static load tests was conducted on seven RC T-beams. Based on the experimental observations and considering the effects of high-temperature concrete spalling and steel–concrete bond degradation, a numerical model was developed to simulate the temperature distribution and structural behaviour of RC T-beams. The accuracy of the numerical model was validated by comparing the cross-sectional temperature profiles and ultimate bearing capacities after fire exposure with experimental results. A dataset of 500 samples was established, with variables including fire exposure time, depth of concrete spalling, spalling area ratio and loading conditions. Regression fitting and machine learning techniques were used to establish predictive formulas and models for estimating the ultimate bearing capacity of RC T-beams after fire exposure. The accuracy of both methods was found to be within 10%.
Paracellular Transport and Renal Tubule Calcium Handling
Authors: Yu Alan S.L. , Curry Joshua N.
Published: August 2024

The kidney plays a major role in maintenance of serum calcium concentration, which must be kept within a narrow range to avoid disruption of numerous physiologic processes that depend critically on the level of extracellular calcium, including cell signaling, bone structure, and muscle and nerve function. This defense of systemic calcium homeostasis comes, however, at the expense of the dumping of calcium into the kidney tissue and urine. Because of the large size and multivalency of the calcium ion, its salts are the least soluble among all the major cations in the body. The potential pathologic consequences of this are nephrocalcinosis and kidney stone disease. In this review, we discuss recent advances that have highlighted critical roles for the proximal tubule and thick ascending limb in renal calcium reabsorption, elucidated the molecular mechanisms for paracellular transport in these segments, and implicated disturbances in these processes in human disease.
Maps and the Burdens of Belonging: Identity and Resistance in Gurnah’s By the Sea and Owuor’s The Dragonfly Sea
Authors: Binju Gargi
Published: August 2024

This article examines the relationship between maps, identity, and belonging in two post-colonial  novels set in the Western Indian Ocean region: Abdulrazak Gurnah’s By the Sea (2001) and Yvonne Adhiambo Owuor’s The Dragonfly Sea (2019). Through close textual analysis, I argue that these novels portray maps not merely as static remnants of colonialism but as dynamic artefacts that both reflect and shape post-colonial identities in nuanced ways. I highlight how these novels depict maps as having a degree of agency, capable of both oppressing and offering pathways to self-discovery for post-colonial subjects. By highlighting the themes of naming, representation, and identity concerning maps across both texts, I argue for a coherent cross-reading of the plurality and contestation inherent in the post-colonial reading of maps.
The Importance of Reservoir Geomechanic Modelling for Carbon Sequestration, Storage, and Utilization: A Case Study from East Natuna
Authors: Cherdasa Jeres Rorym , Ariadji Tutuka , Sapiie Benjamin , Siagian Ucok W.R.
Published: August 2024

East Natuna is well known for its huge natural gas reserves with a very high CO2 content. The appearance of CO2 content in an oil and gas field is always considered as waste material, and will severely affect the economic value of the field. The higher the content, the more costly the process, both technically and environmentally. In this research, the newly proposed reservoir management approach called CSSU (Carbon Sequestration, Storage, and Utilization) method is trying to be applied to change the paradigm of CO2 from waste material into economic material. The CSSU method is an integration of geological, geophysical, reservoir engineering, and engineering economics with the determination of technical and economic optimization of the use of CO2 produced as the working fluid in a power generation system that has been conditioned through an injection-production system in geological formations. Reservoir simulation modeling is done by three models, namely: Compositional, Compositional + Geomechanical Coupling, and Compositional + Geomechanical Coupling + Thermal. There is a difference in the the total injection between Compositional + Geomechanical Coupling and ordinary Compositional simulations of 1-2 % due to factors such as Modulus Young, Poisson's Ratio, Angle of Internal Friction, and Biot's Coefficient which affect the reservoir pore volume calculations and the total CO2 fluid injection calculation. The changes in geomechanical parameters will affect the CSSU techno-economic analysis where a 30 % change in the rock compressibility and poisson ratio parameters will effect changes in the electrical energy amounts being produced by 0.01 MW or 0.33 %, and in an economic value of 4 MMUS $ or 2.24 %.
Pandemi Sürecinde Öğretmenlerin Psikolojik Sağlamlık Düzeyleri ile Hayat Boyu Öğrenme Yeterlilikleri Arasındaki İlişki
Authors: Özsoy Metin , Akfırat Osman Nejat
Published: August 2024

Bu araştırma, pandemi sürecinde görev yapan öğretmenlerin psikolojik sağlamlıkları ve hayat boyu öğrenme yeterlilikleri değişkenleri arasında bulunan ilişkiyi incelemeyi amaçlamaktadır. Araştırma İstanbul ili Tuzla ilçesinde görevine devam eden 414 öğretmenle gerçekleştirilmiştir. Veri toplama aracı olarak Yaşam Boyu Öğrenme Anahtar Yeterlikleri Ölçeği ve Yetişkin Psikolojik Sağlamlık Ölçeği kullanılmıştır. Veri analizinde t testi, ANOVA, korelasyon ve regresyon uygulanmıştır. Normal dağılım göstermeyen alt boyutlar için parametrik olmayan testler kullanılmıştır. Ulaşılan sonuçlar, öğretmenlik mesleğine devam eden kişilerin psikolojik sağlamlıklarının ve hayat boyu öğrenme yeterlilik düzeylerinin iyi durumda olduğunu göstermiş, eğitim düzeyi ve mesleki çalışmalara katılım geçmişi gibi faktörlerin bu yeterlikleri etkilediğini ortaya koymuştur. Psikolojik sağlamlık açısından yaş ve medeni durumun etkisi belirlenmiştir. Ayrıca, öğretmenlerin hayat boyu öğrenme yeterlilikleri ile psikolojik sağlamlıkları arasında korelasyonel olarak anlamlı bir ilişki olduğu ve regresyon analizine göre öğretmenlerin hayat boyu yeterlilik düzeylerinin psikolojik sağlamlık düzeylerini yordadığı tespit edilmiştir. Hayat boyu öğrenme yeterliliği öğretmenler için psikolojik sağlamlıkları adına koruyucu bir faktör olarak nitelenebilir. Araştırmadan elde edilen sonuçlar, ilgili alan yazınıyla uyumlu olarak tartışılmıştır. Psikolojik sağlamlık kavramının günümüz dünyasında büyük önem kazandığı göz önüne alındığında mevcut koruyucu faktörlere bilimsel olarak yenilerini ekleyebilmek oldukça önemlidir. Öğretmenlere yönelik eğitim programları ve faaliyetler, öğretmenlerin hayat boyu öğrenme becerilerini desteklemeye yönelik olarak tasarlanması ve uygulanması öneri olarak sunulabilir.
Sınıflarında Mülteci Çocuklar Bulunan Okul Öncesi Öğretmenlerinin Aile Katılımı Çalışmalarına İlişkin Görüşlerinin İncelenmesi
Authors: Güngör Burcu , Gügen Rabia Hümeyra , Çap Aleyna , Gündoğdu Ayşenur , Öztürk Zehra , Yanıkcan Mina Ecem , Bekar Rabia Yaren
Published: August 2024

Bu araştırma, sınıfında mülteci çocukların bulunduğu okul öncesi öğretmenlerinin aile katılımı çalışmalarına yönelik görüşlerini incelemeyi ve deneyimlerini belirlemeyi amaçlamaktadır. Fenomenolojik bir araştırma yaklaşımı benimsenmiştir. Araştırmanın verileri, ölçüt örneklem yöntemiyle belirlenen 12 farklı okuldan 28 okulöncesi öğretmeni ile yapılan yarı yapılandırılmış görüşmeler aracılığıyla toplanmıştır. Elde edilen veriler kodlanarak temalara ayrılmış ve içerik analizi ile değerlendirilmiştir. Araştırmanın sonuçlarına göre, öğretmenler mülteci ailelerle en sık telefon aracılığı ile arama ve mesajlaşma, yüz yüze iletişim, çeviri programları ve tercümanlar aracılığı ile iletişim kurmaktadır. Ayrıca, aile katılımı çalışmaları çoğunlukla anne – çocuk etkinlikleri, bilgilendirme toplantıları, kültür tanıtımı ve mutfak etkinlikleri şeklinde gerçekleştirilmektedir. Öğretmenlerin mülteci ailelerle yaşadıkları sorunlar arasında sınıfların kalabalık olmasından dolayı öğretmenlerin mülteci çocuklara ve ailelerine ayıracak vaktinin ve göstereceği ilginin yeterli olmaması, dil sorunu yüzünden mülteci aileler ile sağlıklı bir iletişim kuramaması, güvenilir çeviri kaynaklarının az olması ve Türkçe dil kurslarının yetersiz olması öne çıkmaktadır. Çalışmaya katılan öğretmenler, ailelerden çocuğun evdeki gelişimlerine destek olmalarını ve okulla iş birliği yapmalarını beklemektedir. Bu çalışma, mülteci aileler ile çalışan öğretmenlerin çocukların gelişimlerini destekleme, maddi ve manevi olarak çabalarının karşılığını alma gibi içsel – dışsal motivasyon kaynaklarına sahip olduklarını ancak zaman zaman mülteci ailelerin dilini bilmedikleri ve mülteci ailelerle çalışmada deneyimsiz oldukları için kendilerini yetersiz hissettiklerini ortaya koymaktadır.
A EFICÁCIA DA SEITAI TERAPIA INSTRUMENTAL NO MANEJO DA DOR LOMBAR: UMA ABORDAGEM INTEGRATIVA E HOLÍSTICA
Authors: Gurek Erivelton Fontes , Pinto Junior Airton Rodrigues
Published: August 2024

Este estudo visa analisar a eficácia da Seitai terapia instrumental, uma técnica oriental focada no realinhamento estrutural e muscular, na gestão da Dor Lombar (DL). Por meio de uma revisão detalhada da literatura existente, examinamos os tipos de DL, os mecanismos fisiológicos subjacentes à Seitai e sua aplicabilidade na prática clínica contemporânea, enfatizando a necessidade de abordagens holísticas e multidisciplinares no tratamento da dor. A Dor Lombar é um problema clínico e socioeconômico significativo, afetando a qualidade de vida e a capacidade de trabalho. Classificada de aguda a crônica, este estudo foca na terapia Seitai como uma abordagem promissora para seu tratamento. A DL é uma das principais causas de incapacidade global, afetando pessoas de todas as idades e profissões. Sua etiologia varia, sendo a dor mecânica relacionada a componentes estruturais da coluna vertebral a mais comum. O diagnóstico e tratamento da DL representam desafios, especialmente devido à sua natureza muitas vezes idiopática. Abordagens multidimensionais são essenciais para um tratamento eficaz. A Seitai terapia instrumental, uma técnica da Medicina Oriental, foca no realinhamento estrutural e muscular, oferecendo uma intervenção não farmacológica e minimamente invasiva. Este método realça o autocuidado e a recuperação funcional, utilizando instrumentos específicos para aplicar estímulos mecânicos, promovendo mecanotransdução e reparação de tecidos. Estudos mostram que a Seitai é eficaz no tratamento da DL, proporcionando benefícios desde o alívio sintomático até a melhoria na função física e modulação da dor. A inclusão desta técnica em tratamentos multidisciplinares pode ser benéfica para o manejo eficaz da DL.
Bilateral Localised Primary Ureteric Amyloidosis
Authors: Padmanabha Vijayan
Published: August 2024

Amyloidosis is a group of diseases in which insoluble proteins called amyloids deposit in tissues and cause problems with body functions. It is not a form of cancer but is a serious condition. It may be symptomatic or localized. The latter is a rare condition and the affection of the ureter has been reported in fewer than 50 cases so far. This case is unique because of its presentation with features of a urothelial tumor of the upper tract and bilateral involvement of the ureter. The affection of the ureters was separated by more than a decade. Given the knowledge gained after treating the first lesion, it was possible to anticipate and suspect a similar lesion affecting the other ureter. A conservative and reconstructive surgery was performed with gratifying results.
Nuclear Isolation and Purification Protocol for Single-Cell Methods v1
Authors: Barreto Corona Guillermo , Hall Amelia
Published: August 2024

This protocol describes how to isolate and purify nuclei from solid tissue for use in single-cell library construction methods. The resulting nuclei are suitable for a variety of single-cell assays such as droplet-based methods like 10x Genomics Chromium and hybridization-based methods like SHARE-seq. Through sequencing we have verified that the resulting nuclei created through this protocol show a low percentage of mitochondrial RNA.
Immunofluorescence and confocal microscopy v1
Authors: Adriaenssens Elias
Published: August 2024

This protocol details the process of immunofluorescence and confocal microscopy.
Purification of SRC kinase v1
Authors: Adriaenssens Elias
Published: August 2024

This protocol details the purification of SRC kinase.
Treatment of D. melanogaster with small molecules in fly food v1
Authors: Kaempf Natalie , Verstreken Patrik
Published: August 2024

This protocol describes the preparation of fly food with small molecules to treat flies during their aging. It can be adapted for any treatments. Details for small molecules used can be found in the "Materials" section
Purification of CCPG1-GST v1
Authors: Adriaenssens Elias
Published: August 2024

This protocol details the purification of CCPG1-GST, its analysis by SDS-PAGE and Coomassie staining.
Methods and instruments used in the literature to quantitatively analyze the acceptability of pharmaceutical interventions for the prevention and treatment of neglected tropical diseases: a systematic review v1
Authors: Duguay Claudia
Published: August 2024

Acceptability is one of the four core components of the right to health and one of the seven factors that are considered in formulating recommendations as part of the World Health Organization guidelines, yet it remains challenging to define and measure.Neglected tropical diseases (NTDs) are a group of 21 diseases that affect people living in vulnerable circumstances, and it is estimated that over 1.6 billion people worldwide require either preventive or curative interventions for at least one NTD. Quantitatively measuring a subjective attribute, such as the acceptability of pharmaceutical interventions for the prevention and treatment of NTDs, presents a fundamental challenge. In this systematic review, We will comprehensively outline various methodologies employed to measure and analyze acceptability of pharmaceutical interventions across different studies and NTDs.
Baseplate Implantation for Two-Part Chamber System v1
Authors: Choi Jiwon , Amjad Usamma , N Schwerdt Helen
Published: August 2024

This protocol describes how to implant a "baseplate" onto the skull. The baseplate forms the bottom layer of the full chamber, which is completed in the second surgical procedure by mounting a "second" or "third" phase (described in another protocol entitled, "Craniotomy, and Second and Third Phase Implantation to Complete Two-Part Chamber System"). The baseplate is thin enough (8 - 10 mm) that it can be completely enclosed subcutaneously. Therefore, this piece is implanted first and as a separate piece in order to create an aseptic environment for healing and to promote osseointegration without risk of infectious species spreading through the chamber margins.
Immunoprecipitation v1
Authors: Adriaenssens Elias
Published: August 2024

This protocol details the process of immunoprecipitation.
Purification of GST-WIPI1/WIPI2d/WIPI3/WIPI4 v1
Authors: Adriaenssens Elias
Published: August 2024

This protocol details the purification of GST-tagged WIPI1/2d/3/4.
Purification of GST-TEX264 v1
Authors: Adriaenssens Elias
Published: August 2024

This protocol details the purification and analysis of GST-TEX264.
Análisis del tiempo de crecimiento bacteriano en los hemocultivos realizados en un hospital de la orinoquía colombiana
Authors:   Hospital Regional de la Orinoquía, Aranguren Reina Erika Marcela , Saavedra Parra Julio César ,   Hospital Regional de la Orinoquía, Avellaneda Curcho Luis Carlos ,   Hospital Regional de la Orinoquía, García Agudelo Lorena ,   Hospital Regional de la Orinoquía
Published: August 2024

Introducción: Las infecciones del torrente sanguíneo han presentado cambios importantes en su epidemiología, etiología y clínica, destacándose actualmente por su significativa morbilidad y mortalidad, además de un aumento en su incidencia en todo el mundo. Objetivo: determinar tiempo de crecimiento bacteriano en los hemocultivos y compararlo entre bacterias gramnegativas y grampositivas. Materiales y Métodos: Estudio descriptivo y retrospectivo de todos los hemocultivos tomados a la población atendida con sospecha de sepsis en un hospital en los años 2021 y 2022. Resultados: Un total de 5257 hemocultivos, con crecimiento bacteriano en el 21,15% (1112) de las muestras, bacterias gram negativas el 65,29% (n=726) y grampositivas 34,71% (n=386). El tiempo más corto de crecimiento bacteriano en todos los hemocultivos se presentó en Klebsiella pneumoniae ssp pneumoniae (3,60 horas) y el tiempo máximo de crecimiento bacteriano fue en Staphylococcus hominis ssp hominis (93,80 horas). El tiempo mínimo de crecimiento bacteriano de gram negativas, la media fue de 15,86 horas (DE ± 10.78 horas). El tiempo mínimo de crecimiento bacteriano de gram positivas, la media fue de 16,41 horas (DE± 8,20 horas). Conclusiones: Los tiempos de crecimiento bacteriano son similares en bacterias gram negativas y gram positivas, sin embargo, se destaca que el tiempo mínimo de crecimiento se obtuvo en un germen gram negativo y el máximo en un germen gram positivo.
Artificial deformity creation in treatment of soft tissue wounds and lower leg bones defect: a case report
Authors: Khominets Vladimir V. , Mikhailov Sergey V. , Shchukin Alexey V. , Nagornyi Evgenii B. , Zhumagaziev Sayan E. , Tsoy Danil R.
Published: August 2024

Background. The problem of treating wounded patients with defects of soft tissues and bones of the extremities continues to be relevant. One of the ways to close soft tissue defects, especially in case of bone tissue loss, after open fractures of the extremities is acute shortening and creation of artificial angular deformity of the segment.
The aim of the study — to demonstrate the possibilities of acute shortening and angulation of the segment as a technique to replace soft tissue and bone defects in treatment of a patient with a gunshot wound to the lower leg.
Case description. A 30-year-old wounded man was admitted to the clinic with an extensive defect in soft tissues and bones of the lower leg in the middle third. To reduce the wound size, acute shortening and angulation of the lower leg was performed. The intentional angular deformation was 24º, shortening — up to 8 cm. The residual soft tissue wound defect was closed with local tissues and split skin autograft. The tibia was fixed by the Ilizarov hinge-distraction apparatus with following gradual correction of the angular deformity. After that, one performed osteotomy of the tibia in order to eliminate shortening with the Ilizarov method (the distraction rate of 1 mm per day). After restoring the length of the lower leg, in order to replace the defect along the anterior surface of the tibia, a marginal “flake” was formed from a displaced fragment. At a follow-up examination, in 18 months after the injury the patient walks with full weight bearing on the injured limb without any additional means of support, continues to perform military service duties in accordance with his position.
Conclusions. The presented clinical case demonstrates that acute shortening of a limb segment with creation of artificial angular deformity is an effective method for temporary closure of a gunshot defect of soft tissues. The technique allowed closing critical soft tissue defect of the lower leg and restoring the anatomy (length) of the segment. Consequently, one was able to achieve satisfactory treatment results and restore the functions of an injured limb. Besides, acute temporary shortening technique eliminated the need to perform technically sophisticated and lengthy microsurgical reconstructions, which are associated with a flap replacement for closure of soft tissue defects in a shotgun fracture area.
The Cytotoxicity of Agaro-Oligosaccharides and Neoagaro-Oligosaccharides on Macrophage Cells
Authors: Pratitis Visi Endah , Puspitasari Pinki Anggrahini , Hanbal Mayland Muhammad , Tsabitah Khansa , Juliadmi Dian , Saksono Budi , Wijayanti Nastiti
Published: August 2024

Agarose is a polysaccharide from red algae. Enzymatic hydrolysis of agarose can produce Agaro-Oligosaccharidess (AOS) and Neoagaro-Oligosaccharidess (NAOS). Different times of enzymatic hydrolysis can produce different types of AOS and NAOS based on their degree of polymerization (DPs). This study aims to examine the cytotoxicity of AOS and NAOS with different hydrolysis times on the macrophage cell line RAW 264.7. The parameters used were the percentage of cell viability and IC50 value. The cytotoxicity test using MTT assay and One-way ANOVA were used as statistical tests. The results showed that AOS-0 at a concentration below 125 µg/mL was not toxic and showed moderate toxicity up to a high concentration of 1000 µg/mL, while AOS hydrolyzed for 24 h (AOS-24) was not toxic to RAW 264.7 cells at all concentrations tested. The different results were shown in all NAOS samples, which were highly toxic to RAW 264.7 cells in the 125 to 1000 µg/mL, indicating that it was concentration dependent. The results showed that different hydrolysis times caused differences in the structure of AOS and NAOS compounds and influenced the toxicity level. Research development for further studies on antioxidants and anti-inflammatory needs more attention to the sample type and hydrolysis time.
Effect of Nutritional Supplementation High in Polyunsaturated Fatty Acids (PUFA) on the Nutritional Status of Advanced Cervical Cancer Patients Receiving Radiotherapy
Authors: Wuryanti Sri
Published: August 2024

BACKGROUNDIn 30-90% of cancer patients, weight loss is caused by inadequate intake, changes in metabolism, and inflammatory and humoral responses between the host and tumor. Longitudinal studies have shown that cancer patients who experience weight loss have a worse prognosis than those with stable weight. This change is thought to affect therapeutic response. Polyunsaturated Fatty Acids (PUFA) omega-6 : omega-3 intake ratio of about 1-2 : 1 may fight cancer growth. Several publications reported that PUFA omega-3 has pro-apoptotic, anti-inflammatory, anti-proliferative and anti-angiogenic effects. This study aims to determine the effect of high PUFA nutritional supplementation on the nutritional status of advanced cervical cancer patients who receive radiotherapy.METHODSThis study was a double-blind Randomised Clinical Trial on advanced cervical cancer patients at the Radiotherapy Department, Cipto Mangunkusumo Hospital (RSCM), Jakarta, from April 2013 to April 2014. The study subjects were taken consecutively, through randomization divided into two groups, namely the treatment and control groups. During radiation, the subjects received nutritional supplementation containing isocaloric and isoproteins with a ratio of omega-6 : omega-3 fatty acids = 1.27 : 1 and control. During treatment, weekly evaluations were conducted, including body weight and acute radiation side effects.RESULTSA total of 31 subjects out of 45 subjects were able to complete the study, with 16 subjects in the treatment group and 15 subjects in the control group. Before treatment, socio-demographic status, omega-6 and omega-3 fatty acid intake patterns, nutritional and clinical status were not significantly different. The body weight of the treatment group that received high PUFA nutritional supplementation with a ratio of omega-6 : omega-3 fatty acids = 1.27 : 1 was relatively more stable, while the control group that received nutritional supplementation without PUFA decreased (p = 0.539), but the ∆ weight loss in each group was not significantly different (p = 0.149).CONCLUSIONSPUFA supplementation can maintain the nutritional status of cervical cancer patients by maintaining body weight.
Knowledge attitude and practice of pharmacovigilance among community pharmacy in India: a questionnaire study
Authors: Selvam Sindhu , Karthik S. , Sankaravadivel Asha Rani , Durai Kalai Selvi , Rajarathinam Narmatha , Raja Sneha , Jothibabu Ishwaryaa
Published: August 2024

Background: Pharmacovigilance (PV or PhV), also known as drug safety, is the pharmacological science relating to the collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. The Pharmacovigilance Program of India (PvPI), which has been functioning since July 2010, was renamed by the Ministry of Health and Family Welfare of the Indian government. This study main objective to assess the current knowledge, attitude and practice of pharmacovigilance in community pharmacist.
Methods: Self-prepared and validated questionnaires were distributed among community pharmacists in India through online forms for 8 months, a cross-sectional questionnaire-based survey was used, with convenience sampling utilized. Responses from 2205 subjects were analyzed.
Results: The primary objective of this study was to assess the demographic details of the community pharmacists as well as the distribution of knowledge, Attitude, Practice on Pharmacovigilance, out of 2205 Community Pharmacist 1109 (50.3%) were male and 1016 (49.7%) were female. More than half of the respondents (54%) was familiar about the definition of pharmacovigilance. Out of 2205 respondents, 240 respondents thought that reporting adverse drug reaction is unnecessary. Among 2205 respondents, 445 respondents have not experienced ADR in their patients during their professional practice.
Conclusions This study determined the Assessment of Knowledge, Attitude and practice of Pharmacovigilance among Community Pharmacist in India. According to this study, community pharmacists are good in attitude but they were not knowledgeable and not effective in practice.
A case of generalized bullous fixed drug eruptions induced by ceftriaxone
Authors: Rathva Trushti , Sinha Anita , Solanki Vaibhav , Kanjariya Dilip
Published: August 2024

Fixed drug eruption (FDE) is a delayed-type hypersensitivity reaction to a systemic medication. Generalized bullous fixed drug eruption (GBFDE) is a rare variant involving generalized bullae and erosions across multiple anatomical sites. A 66-year-old female with dialysis-dependent chronic kidney disease presented with fever and chills, and subsequently developed multiple erythematous to bluish annular nodules with central bullae on the hands, feet, tongue, buccal mucosa, and lips after ceftriaxone administration. Clinical examination revealed no prior history of drug allergies. Diagnostic assessments showed elevated serum creatinine and other parameters consistent with renal impairment. The suspected drug was discontinued, and patient treated with oral prednisolone, levocetirizine, topical betamethasone, and fusidic acid. Oral paste and gargles were prescribed for mucosal involvement. This case highlights the importance of recognizing ceftriaxone-induced GBFDE, particularly in patients with chronic kidney disease on haemodialysis. Prompt identification and cessation of the offending drug, along with appropriate therapeutic interventions, are critical for preventing future episodes and ensuring patient safety.
Evaluation of primary high-grade osteosarcoma by surgical resection in PT Birta city hospital
Authors: Belbase Rupesh Jung , Rayamajhi Asmita , Lamichhane Ritu , Basnet Anil Kimar , Limbu Kumud Kumar , Nepali Dikshya
Published: August 2024

Background: Classic OS had a 20% five-year survival rate during most of the 20th century. Adjuvant chemotherapy was first used to treat OS in the 1970s, raising survival rates to 50%. The standard course of treatment for OS includes surgery, neoadjuvant chemotherapy, and adjuvant chemotherapy. When treating a patient with soft tissue and bone sarcomas, the extent of surgical procedures is frequently described using surgical oncologic classifications. Radical resection refers to the removal of the whole bone or compartment harboring the tumor, whereas wide resection refers to the removal of the affected area of the bones with a cuff of healthy tissue.
Methods: The study conducted a retrospective analysis of 120 patients who visited to orthopedic outpatient department of PT Birta city hospital and research center, Nepal from October 2019 to November 2022. Radical resection was defined as the removal of the entire affected bone, while wide resection was described as partial bone excision. The baseline characteristics of the patients were analyzed and the data regarding radical and wide resection in osteosarcoma (OS) was evaluated.
Results: The analyzed report shows that 65/120 (54.1%) radical resections and 55/120 (45.8%) wide excisions were the extent of the resection. On the other hand, a central review of the extent of resection data revealed 100/120 (83.3%) wide excisions and 20/120 (16.6%) radical resections.
Conclusions: OS is currently treated with extensive resection, neoadjuvant chemotherapy, and adjuvant chemotherapy, with a strict emphasis on the overall intensity of treatment and prompt restart of post-resection chemotherapy.
Functional outcome of intertan nailing in intertrochanteric fractures: a retrospective study utilizing Oxford hip score
Authors: S. S. Varun Roheet , E. R. Mithun , S. Muthukumar
Published: August 2024

Background: This study evaluates the functional outcome of intertan nailing in intertrochanteric fractures in terms of the Oxford Hip Score (OHS).
Methods: Twenty-eight patients (10 males, 18 females, mean age: 75.2 years, range: 60-94 years) were analyzed. Mean follow-up period was 6 months (3–8 months) and 5 patients were lost to follow-up.
Results: The overall average OHS was 37.2, with scores varying from 22 to 47. Nine patients had OHS scores above 40, indicating satisfactory function, while 10 patients scored between 30-39, denoting mild loss of function. Four patients had OHS scores of 20–29, indicating a moderate to severe loss of function.
Conclusions: These findings indicate the varied functional outcomes of intertan nailing in intertrochanteric fractures and highlight the importance of individualized treatment strategies.
A study of outcome of diaphyseal fractures of radius and ulna in paediatric age group treated with titanium elastic nailing system
Authors: Bedge Vijayanand , M. V. Rakesh , B. Darshan , Belaval Naveen M.
Published: August 2024

A study of outcome of diaphyseal fractures of radius and ulna in paediatric age group treated with titanium elastic nailing system. The current study is an attempt to find out the functional outcome, radiological union, and complications of paediatric diaphyseal radius and ulna fracture treated with titanium elastic nail. This is a prospective study of twenty-five patients of age group 6 years to 16 years diagnosed with a diaphyseal fracture of radius and ulna treated with percutaneous nailing with titanium elastic nails in Department of Orthopaedics, S Nijalingappa Medical College and HSK Hospital, Bagalkot between November 2019 to April 2022. Clinical, functional and radiological outcomes were assessed with Anderson et al criteria for 6 months. In terms of union and range of motion using Anderson et al criteria 20 patients had excellent results, 2 patients had satisfactory results and one patient had an unsatisfactory result. There were no cases of poor results. Five cases had complications like Nail prominence, elbow stiffness, olecranon bursitis and super skin infection. The radiological union was achieved in a mean time of 8.24±2.62 weeks. Complications resolved after implant removal. Titanium elastic nail system showed excellent results in terms of bony union, functional outcome with minimal complications which resolve after nail exit. Therefore, titanium elastic nail system should be considered as an effective alternative of conservative management for forearm fractures in pediatric age group.
Diagnosis of ADSSL1 Mutation-Induced Myopathy Through Electrophysiology and Genetic Tools
Authors: Chae Dong Jin , Lee Yung Jin , Hong Mi Jin , Sim Cho E. , Kim Seung-Eun , Park Jong Bum
Published: August 2024

Mutations in the adenylosuccinate synthase 1 (ADSSL1) gene, resulting in adenylosuccinate synthase deficiency, are a rare genetic anomaly characterized by muscular weakness, elevated serum creatine kinase levels, and pathological muscle findings. However, these clinical symptoms are similar to those observed in many other myopathies, increasing the risk of misdiagnosis. In an era of rapidly expanding genetic knowledge, the authors sought to verify the diagnostic utility of electromyography for genetic disorders. Through combined electrophysiological and genetic studies, a patient initially thought to have Becker’s muscular dystrophy was conclusively diagnosed with ADSSL1 mutagenic myopathy. This case underscores the importance of re-evaluating diseases that do not follow the typical clinical progression of traditional myopathies, especially in light of recent diagnostic advancements.
Prevention and Treatment of Post-Paralytic Synkinesis: Critical Changes Following Severe Facial Palsy
Authors: Kim Jin
Published: August 2024

Facial synkinesis following severe facial palsy has been observed clinically across a wide range of patient groups, from infants to older adults, indicating that it is not limited to any specific demographic. In one of the largest studies on the natural progression of idiopathic peripheral facial nerve palsy, synkinesis was reported in approximately 16% to 55% of patients. The severity of facial synkinesis generally correlates with the severity of the initial facial palsy. Various types of nerve injuries have been categorized based on the extent of damage to the endoneurium, perineurium, and axons. Aberrant responses and ephaptic transmission following facial nerve injury are responsible for the clinical manifestations of facial synkinesis. It is crucial to minimize facial synkinesis in the early stages and to ablate it in the chronic stages to effectively manage this challenging complication following severe facial palsy. We advocate for physical therapy, including neuromuscular retraining during the acute phase, as a viable option for patients at high risk of developing facial synkinesis after a severe episode of Bell’s palsy. This approach helps prevent excessive movement (hyperkinesis) and enables patients to recognize and manage unwanted co-contractions (synkinesis). Several treatments targeting the facial nerve and muscles are available, including chemo-denervation, selective myectomy, and selective neurectomy. These interventions aim to address aberrant regeneration and peripheral ephaptic transmission.
Antioxidants and their vital significance in periodontal health
Authors: Gupta Anjali , Singh Siddharth Kumar , Mathur Tushar , Roy Sayak
Published: August 2024

Given that periodontitis is so common worldwide, there is growing interest in this condition. The disruption of the vital balance between the virulence factors generated by bacteria and the inflammatory host response leads to this inflammatory disease. Several attempts have been made before to treat this illness and restore periodontal health. The gold standard has been seen to be nonsurgical debridement, which targets the underlying cause. Nonetheless, studies have indicated that an unbalanced diet and dietary deficiencies may have an impact on the periodontium. Therefore, an effort toward the maintenance of optimal conditions, as well as the improvement of oral health, necessitates the introduction of adjunctive nutritional therapy, which can benefit the patients. Antioxidants in the diet have some remarkable benefits and valuable properties that play an irreplaceable role in the maintenance of periodontal health. These have emerged as excellent adjuncts that can enhance the outcomes of conventional periodontal therapy. The aim of this review article is to highlight some of these dietary antioxidants that can make a notable difference by striking a balance between health and disease.
A rare case of an aggressive dentigerous cyst associated with a supernumerary tooth
Authors: George Megha Mary , Abraham Lijoy , Naikmasur Venkatesh , Nandimath Kirty
Published: August 2024

Dentigerous cyst is the most common developmental odontogenic cyst which is associated with an impacted tooth and are commonly diagnosed at an early age. If unnoticed they can grow and expand into a large lesion. In this article, we report a case of a large dentigerous cyst which was aggressive and expansile involving the mandible, crossing the midline and associated with a partially developed, supernumerary tooth. The patient was a 48-year-old male, who had noticed a swelling in the oral cavity for 2 years. The patient was treated with cystic enucleation and the postoperative healing was satisfactory.
Polidocanal sclerotherapy for lingual hemangioma- A case report
Authors: B Utham Chand , B Aravind Anto , Sharma Amit Kumar , Sharma Vikram , Kumar Praveen , Tomar Mridang
Published: August 2024

Hemangiomas are benign growths characterized by abnormal blood vessel proliferation, frequently found in the head and neck area, including the tongue, cheek mucosa, and lips. They are among the most common neoplasms in infancy, with prevalence estimated at 1-3% in neonates and 10% in one-year-old children. Females and Caucasians are more commonly affected, with 60% of cases occurring in the head and neck region. Typically, hemangiomas present as single lesions in 80% of cases and are thought to be developmental rather than neoplastic. Despite their benign nature, oral hemangiomas pose clinical challenges in dentistry due to potential complications such as bleeding and ulceration. Treatment approaches vary and should be tailored to individual cases for the best outcomes. Sclerotherapy is highlighted as a non-invasive and cost-effective method that swiftly achieves satisfactory results. This case study illustrates successful treatment of a tongue hemangioma using sodium tetradecyl sulfate, a sclerosing agent, which resulted in complete resolution of the lesion, underscoring sclerotherapy's efficacy as a prompt and nonsurgical treatment option.
Decode telangiectatic granuloma- A case report
Authors: Ahuja Annapurna , Zarrin Rabia , Manisha  , Roy Supratik
Published: August 2024

A benign hyperplastic lesion called an oral telangiectatic granuloma typically develops in the mouth as a result of trauma or long-term irritation. It is a non-neoplastic lesion which is known by various names according to its etiopathogenesis. The term "telangiectatic granulomas" describes the histological characteristics of these tumors, which include subepithelial proliferation of small, thin-walled blood vessels in the loose connective tissues, inflammatory cell infiltrates, and typical granulation tissue. It is an inflammatory lesion that affects skin, oral mucosa, gingiva, lips, tongue & skin. The term pyogenic granuloma is actually a misnomer. This case study describes an 18-year-old female patient who experienced swelling in the jaw's mandibular front tooth region for two months. Following an internal bevel gingivectomy, a telangiectatic granuloma was suggested by the histological result. Three months later, there has been no reduction in the keratinized tissue's width. After the etiological factor is eliminated, the sample is surgically excised and sent for a biopsy. Although there is a potential of relapse, this is the recommended course of treatment for Telangiectatic Granuloma.