bluuebunny/crossref_metadata_2025 huggingface dataset:
Nurturing Teacher Resilience: Transformational Leadership as a Protective Factor Against Burnout
Authors: Marwani Marwani , Megayanti Windi , Ilias Mohd Faeez
Published: January 2025

This study aims to analyze the role of transformational leadership in overcoming teacher burnout in schools. This study uses a qualitative approach with a case study design, where data is collected through interviews, observations, and documentation. Techniques for filtering important information, presenting structured data, and drawing accurate conclusions based on existing findings are used to analyze the data. The results of the study indicate that transformational leadership in schools plays an important role in overcoming teacher burnout. Idealized influence creates a sense of trust and recognition while inspiring motivation and connects teachers' work to a larger purpose, thereby helping to reduce burnout. Intellectual stimulation encourages creativity and innovation through open communication, which also contributes to preventing burnout. In addition, individual consideration provides personalized support and supports the professional growth and emotional well-being of teachers, thereby reducing the risk of burnout in the school environment. This study provides implications for effective leadership practices in the educational context. It offers insights for principals and education managers to apply a transformational leadership approach to overcome teacher burnout in schools.
Inspiring Excellence: How Transformational Leadership Shapes Institutional Performance in Higher Education
Authors: Aziz Abd , Rachman Poppy , Zamilah Ainun
Published: January 2025

This study aims to analyze transformational leadership in shaping institutional performance in higher education, based on Bernard M. Bass's perspective integrated with spiritual values and local wisdom. The approach used is a qualitative case study type, where data is collected through interviews, observations, and documentation. Data were analyzed using thematic analysis techniques based on the Miles and Huberman model, which allows the identification of key themes related to transformational leadership practices. The results of the study indicate that the application of transformational leadership that integrates cultural and spiritual values can increase the motivation and involvement of lecturers and staff while contributing to improved academic performance. Through five main dimensions, namely idealized influence, inspirational motivation, intellectual stimulation, individualized consideration, and cultural-spiritual synergy, this study proves that this approach is able to encourage increased institutional performance in higher education. The implication of this study is the importance of considering the cultural and spiritual context in leadership practices in educational institutions. The integration of these values not only creates a harmonious academic environment but also strengthens innovation, collaboration, and engagement, thus supporting the achievement of institutional goals in a sustainable manner.
From Text to Context: Building an Inclusive Organizational Culture in Islamic Boarding School-Based Higher Education Institutions
Authors: Kadi Titi , Tamam Badrut
Published: January 2025

This study aims to analyze the management of the cultivation of Wasathiyah Islamic values in Islamic boarding school-based universities. This study uses a qualitative approach with a case study type. Data collection techniques used include in-depth interviews, observation, and documentation. Data were analyzed through three stages: data condensation, data presentation, concluding, and verifying the findings. The study results indicate that the management of the cultivation of Wasathiyah values in universities is integrated into curriculum planning and campus management, which reflects the principles of religious moderation and diversity. Both universities emphasize role models as the primary method in teaching, with Wasathiyah values implemented in the curriculum and applied in campus life through attitudes of tolerance and inclusivity. Evaluation of the cultivation is carried out periodically to assess the impact and suitability of the program with student needs. This study provides implications for integrating religious moderation values in Islamic boarding school-based higher education to create an inclusive, tolerant academic environment and build moderate character among students. The Wasathiyah-based curriculum can be a model for other universities to develop education that supports religious harmony and social tolerance.
Transforming Education: The Impact of Transformational Leadership on Staff Performance
Authors: Soim Soim
Published: January 2025

This study aimed to examine and analyze the relationship between the variables of idealized influence, inspirational motivation, intellectual stimulation, and individualized consideration on the performance of educational staff. This study used a quantitative and explanatory approach through a survey technique. The questionnaire was compiled based on the research variables, namely transformational leadership and educational staff performance. Because the exact population size is unknown, the sample size was calculated using the Cochran formula. Data were collected from 100 educational staff members who were the sample of this study. Data analysis was carried out using multiple regression analysis and the Sobel test. The results of the study showed that idealized influence had a positive and significant effect on the performance of educational staff; inspirational motivation had a positive and significant effect on the performance of educational staff; intellectual stimulation had a positive and significant effect on the performance of educational staff; and individualized consideration had a positive and significant effect on the performance of educational staff. Leaders and management can utilize this study's results to improve educational staff performance. The variables that affect the performance of educational staff can be used as targets for change to improve performance.
The Influence of B-SE on the Health Behavior of Santri Islamic Boarding School Related to Dengue Fever Prevention
Authors: Dewi Novela Eka Candra , Safitri Siti Zulfiana , Putriyana Sofiyatul , Andini Sulis Cahya
Published: January 2025

Dengue Hemorrhagic Fever (DHF) is a significant health issue in tropical regions, including Indonesia, particularly in environments like Islamic boarding schools with high population density and sanitation challenges. This study evaluates the effectiveness of Booklet-Self Education (B-SE) in improving knowledge and clean and healthy living behavior (PHBS) among students for DHF prevention. Using a quasi-experimental pretest-posttest group design, 204 female students were divided into experimental and control groups, each with 102 participants. The experimental group received B-SE-based health education. Results revealed a significant improvement in the knowledge and PHBS practices of the experimental group, with a p-value of 0.000 (p<0.05). These findings highlight the potential of B-SE as an effective educational tool for fostering PHBS and preventing DHF in boarding school settings. The study suggests that incorporating such educational media into health programs can reduce DHF prevalence and enhance public health awareness in similar environments.
IMPLEMENTASI APLIKASI BANGKIT DALAM VALIDASI DAN VERIFIKASI ANGKA KEMISKINAN
Authors: Hidayat Muh. Ryan Rahmatul
Published: January 2025

Kemiskinan merupakan kondisi di mana kebutuhan dasar manusia, seperti pangan, kesehatan, pendidikan, dan pekerjaan, tidak terpenuhi secara memadai sehingga menghambat kemampuan individu untuk bertahan hidup dan mengembangkan kehidupannya. Di Kabupaten Majalengka, permasalahan kemiskinan teridentifikasi dengan persentase mencapai 11,21%, sementara total jumlah penduduknya sekitar 1,35 juta jiwa. Penelitian ini bertujuan untuk menggali lebih dalam karakteristik kemiskinan serta melakukan verifikasi dan validasi data penduduk miskin, khususnya di Kecamatan Lemahsugih. Metode penelitian yang digunakan adalah metode Deskritp kualitatis. Selain itu, dilaksanakan juga observasi lapangan dan wawancara dengan memanfaatkan aplikasi BANGKIT sebagai sarana untuk menentukan skor akhir kemiskinan berdasarkan indikator-indikator tertentu. Aplikasi ini memungkinkan peneliti untuk menganalisis dimensi-dimensi kemiskinan secara komprehensif dan memperoleh gambaran yang lebih mendalam mengenai kondisi sosial-ekonomi masyarakat setempat. Hasil menunjukkan bahwa Kecamatan Lemahsugih memiliki 3.934 Kepala Keluarga (KK) yang telah terdata sebagai keluarga miskin dan menjadi sasaran utama verifikasi serta validasi. Melalui proses ini, diharapkan akan diperoleh pemahaman yang lebih akurat mengenai penyebab, dinamika, dan sebaran kemiskinan di wilayah tersebut. Dengan demikian, temuan penelitian ini diharapkan dapat menjadi landasan bagi perumusan kebijakan publik yang lebih tepat sasaran, peningkatan efektivitas program penanggulangan kemiskinan, serta penguatan kolaborasi antara pemerintah daerah, lembaga sosial, dan masyarakat dalam upaya pengentasan kemiskinan di Kabupaten Majalengka, khususnya di Kecamatan Lemahsugih.
Optimalisasi Pelayanan Pemerintah Daerah yang Efektif
Authors: Haeranah Haeranah
Published: January 2025

Kebijakan publik merupakan salah satu upaya pemerintah dalam melaksanakan tugas dan fungsinya untuk memenuhi kebutuhan masyarakat. Proses perencanaan, penyusunan, pengundangan, penyebarluasan, implementasi, dan evaluasi kebijakan pemerintah daerah merupakan bagian penting dalam siklus kebijakan publik. Penelitian ini bertujuan untuk mengkaji secara komprehensif proses tersebut dan memberikan pemahaman yang lebih baik tentang peran dan tantangan yang dihadapi dalam pelaksanaannya. Metode yang digunakan dalam penelitian ini adalah studi pustaka dengan pendekatan deskriptif kualitatif. Hasil penelitian menunjukkan bahwa perencanaan kebijakan pemerintah daerah dimulai dari identifikasi masalah, penetapan tujuan, analisis kebijakan, hingga pengambilan keputusan. Setelah perencanaan selesai, kebijakan disusun dan diundangkan agar dapat diketahui oleh publik. Selanjutnya, kebijakan disebarluaskan agar dapat diimplementasikan oleh semua pihak yang terkait. Implementasi kebijakan meliputi tahapan sosialisasi, persiapan, pelaksanaan, dan monitoring serta evaluasi. Evaluasi dilakukan untuk menilai efektivitas dan efisiensi kebijakan serta mengidentifikasi permasalahan yang muncul selama proses implementasi. Dalam proses perencanaan, penyusunan, pengundangan, penyebarluasan, implementasi, dan evaluasi kebijakan pemerintah daerah, terdapat beberapa landasan teori yang dapat digunakan sebagai acuan. Teori pengambilan keputusan dan teori perencanaan strategis merupakan landasan teori yang penting dalam proses perencanaan kebijakan. Sementara itu, teori implementasi kebijakan dan teori evaluasi kebijakan dapat digunakan dalam proses implementasi dan evaluasi kebijakan. Kesimpulannya, proses perencanaan, penyusunan, pengundangan, penyebarluasan, implementasi, dan evaluasi kebijakan pemerintah daerah merupakan proses yang kompleks dan memerlukan dukungan yang kuat dari semua pihak terkait. Penerapan teori-teori yang relevan dapat membantu dalam memperbaiki kualitas kebijakan yang dihasilkan. Oleh karena itu, penelitian dan pengembangan kebijakan publik harus terus dilakukan untuk mencapai tujuan yang diharapkan.
Collaborative Governance Dalam Perencanaan Pembangunan di Kabupaten Bekasi Provinsi Jawa Barat
Authors: Sartika Ika
Published: January 2025

Development planning is a crucial aspect in the implementation of the regional government, but the developments carried out so far tend to be planned centrally was dominated by the regional government. The collaborative governance approach to development planning is believed to be able to improve the quality of development planning that is oriented towards regional progress and community welfare. The study aims to examine collaborative governance in regional development planning along with supporting and inhibiting factors for collaborative governance in regional development planning in Bekasi Regency. The study uses a qualitative descriptive research design, where research data is obtained through data collection techniques of interviews, observations, and documentation studies. The analysis technique uses descriptive techniques including data collection, data condensation, data presentation, and drawing conclusions. The results of the study are as follows: 1) Collaborative governance in regional development planning is not optimal in terms of the weak implementation of face-to-face dialogue, low mutual trust built between collaboration actors, and lack of public trust in the regional development planning process, as well as lack of mutual understanding with the dynamics of differences in interests in the process of preparing regional development planning; 2) Collaborative governance in development planning is supported by the existence of basic rules in the form of regulations at the central and regional levels as references in regional development planning, the availability of adequate human resources in regional development planning, and the facilitative leadership of the Acting Regional Head who is quite proactive in regional development planning. Meanwhile, the inhibiting factors are the absence of a mechanism to increase community participation and the dynamics of differences in interests in regional development planning. Research suggestions require regional governments to initiate joint cross-sectoral forums and community elements that hold intensive dialogues, as well as increasing socialization and education of the community so that they can be proactively involved in providing input and criticism of regional development planning.
 Keywords: Collaborative Governance, Regional Government, Regional Development Planning.
Analisis Kebijakan Kota Layak Anak di Kota Banda Aceh Menurut Indikator Kota Layak Anak
Authors: Nabila Asyiatun , Rassanjani Saddam , Afrijal Afrijal
Published: January 2025

Kota Layak Anak (KLA) merupakan kebijakan strategis yang bertujuan memastikan pemenuhan hak anak melalui sinergi pemerintah, masyarakat, dan dunia usaha. Penelitian ini bertujuan menganalisis implementasi kebijakan KLA di Kota Banda Aceh dengan fokus pada tujuh indikator kelembagaan sebagaimana diatur dalam Peraturan Menteri Negara Pemberdayaan Perempuan dan Perlindungan Anak Republik Indonesia Nomor 12 Tahun 2011 tentang Indikator Kabupaten/Kota Layak Anak. Penelitian ini menggunakan metode kualitatif dengan teknik pengumpulan data berupa wawancara, observasi, dan dokumentasi. Informan terdiri dari aparatur pemerintah, tokoh masyarakat, serta perwakilan lembaga masyarakat yang relevan. Hasil penelitian menunjukkan bahwa Banda Aceh belum sepenuhnya mencapai status Kota Layak Anak. Beberapa indikator kelembagaan, seperti alokasi anggaran khusus dan keterlibatan lembaga masyarakat, telah diterapkan, namun belum optimal. Rencana Aksi Daerah Kota Layak Anak belum tersedia, dan keterlibatan dunia usaha masih terbatas. Di tingkat gampong, pemahaman konsep KLA masih rendah, sehingga implementasi kebijakan belum merata. Diperlukan penguatan sinergitas antara Pemerintah Kota dan gampong, alokasi anggaran khusus, serta pelibatan dunia usaha melalui pembentukan Asosiasi Perusahaan Sahabat Anak Indonesia (APSAI). Dengan langkah-langkah ini, diharapkan implementasi KLA dapat dipercepat, sehingga pemenuhan hak anak di Banda Aceh dapat terealisasi secara menyeluruh.
Membangun Birokrasi yang Responsif melalui Implementasi Prinsip Serve Citizens, Not Customers di RSUD Berkah Kabupaten Pandeglang
Authors: Hadid Qothrunnada
Published: January 2025

Sektor kesehatan merupakan pilar penting dalam pembangunan suatu negara. Telah menjadi kewajiban bagi pemerintah untuk menyediakan pelayanan kesehatan yang bermutu dan sesuai dengan kebutuhan masyarakat. Agar dapat merancang pelayanan kesehatan yang sesuai dengan harapan dan kebutuhan masyarakat, maka diperlukan birokrasi yang responsif dan keterlibatan masyarakat dalam setiap proses pelayanan. Paradigma pelayanan publik baru (new public service) hadir sebagai pendekatan yang relevan untuk mewujudkan pelayanan kesehatan yang lebih berorientasi pada masyarakat. Oleh karena itu, penelitian ini bertujuan untuk memahami bagaimana prinsip Serve Citizens, Not Customers pada New Public Service diimplementasikan dalam konteks pelayanan kesehatan dan kendala apa saja yang dihadapi, tepatnya di RSUD Berkah Kabupaten Pandeglang. Penelitian ini menggunakan metode kualitatif yang pengumpulan datanya dilakukan melalui studi kepustakaan, observasi, dan wawancara. Hasil penelitian ini menunjukkan bahwa RSUD Berkah Kabupaten Pandeglang telah berhasil menerapkan prinsip Serve Citizens, Not Customers dari konsep New Public Service. Selain itu, telah terlihat implementasi yang baik pada aspek fairness (keadilan) serta personal attention (perhatian pribadi). Meskipun demikian, penelitian ini juga mengidentifikasi bahwa aspek reliability (keandalan) dan convience (kenyamanan) masih perlu dioptimalkan serta masih terdapat beberapa kendala yang harus dihadapi untuk meningkatkan kualitas pelayanan secara keseluruhan.
Kata Kunci: Implementasi, Pelayanan Publik, Birokrasi, New Public Service.
LOCALIZING THE SUSTAINABLE DEVELOPMENT GOALS THROUGH VOLUNTARY LOCAL REVIEWS IN THE GAMBIA
Authors: Jonga Modou
Published: January 2025

This paper explores the importance of Voluntary Local Reviews (VLR) in the localization and acceleration of the attainment of a powerful global blueprint to deliver a better future. The paper regard Local voluntary Reviews as accelerators and an inclusive approach for the localization of the 2030 Agenda. According to the 2030 Agenda (A/RES/70/1: Transforming Our World: The 2030 Agenda for Sustainable Development) encourages member states to “conduct regular and inclusive reviews of progress at the national and sub-national levels, which are country-led and country-driven”. The value of VLR in advancing SDG implementation has been increasingly recognized at national and international level. The Paper used documentary sources to gather information relevant to the thematic area. These included journal articles, books, local and regional governments reports. The researcher also examined the VLR pilot reviews in The Gambia supported by the United Nations Department of Economic and Social Affairs (UN DESA) and other relevant partners. The Paper strongly recommends peer-to-peer learning to enrich VLR processes at local level with a view to bolster local action.
Gambaran Lingkungan Fisik, 3M pada Rumah Penderita DBD di Kelurahan Wonosari Jaya Distrik Wania
Authors: Irawan Angki
Published: January 2025

Latar Belakang: Penularan DBD dipengaruhi oleh faktor lingkungan yang meliputi lingkungan fisik, kimia dan biologi. Lingkungan sangat berperan dalam distribusi keberadaan organisme vektor dari penyakit DBD. Tujuan:Tujuan penelitian ini adalah untuk mengetahui gambaran lingkungan fisik rumah, 3M pada rumah penderita DBD di Kelurahan Wonosari Jaya Distrik Wania . Metode: Penelitian ini menggunakan kuantitatif deskriptif dengan populasi dan sampel sebanyak 32 rumah penderita DBD (total sampling). Teknik pengumpulan data mengunakan kuesioner, lembar observasi, dan termohygrometer. Hasil: Hasil penelitian menunjukkan lingkungan fisik (lantai rumah diplester/keramik 29 (90,63%),kepadatan hunian memenuhi syarat 24(75%), ventilasi berkasa memenuhi syarat 24(75%), keberadaan breeding place 16(50%), suhu > 250C 32(100%), kelembaban 40-60% 32(100%)), Pelaksanaan 3M (Menguras tempat penampungan air 25(78,13%), Menutup tempat penampungan air 24(75%), dan Tidak mengubur barang bekas 30(93,75%)). Kesimpulan: lingkungan fisik rumah yang meliputi suhu cukup tinggi, dan pelaksanaan 3M yaitu banyaknya rumah yang tidak mengubur barang bekas. Oleh karena itu diharapkan masyarakat agar melakukan pemberantasan sarang nyamuk dengan menerapkan praktik 3M.
Gambaran Bionomik Nyamuk Anopheles Sp. di RW 02 Kelurahan Kamoro Jaya Kabupaten Mimika
Authors: Marpaung Dhorkas
Published: January 2025

Latar Belakang: Malaria masih menjadi tantangan kesehatan masyarakat utama di dunia, terutama di daerah tropis dan subtropik. RW 02 Kelurahan Kamoro Jaya didapati kondisi lingkungannya ternyata banyak habitat nyamuk Anopheles sp, namun tidak adanya informasi tentang gambaran bionomik nyamuk Anopheles sp. Tujuan: penelitian ini bertujuan untuk mengetahui gambaran bionomik nyamuk Anopheles sp. di RW 02 Kelurahan Kamoro Jaya, Kabupaten Mimika. Metode yang digunakan adalah survei deskriptif, dengan jumlah sampel adalah seluruh tempat perindukan di RW 02 Kelurahan Kamoro Jaya, di mana sampel diambil berdasarkan durasi waktu yang ditentukan dengan menghitung Kepadatan Man Biting Rate (MBR) dan Indeks Habitat Nyamuk. Hasil: Berdasarkan tempat menggigit dikelompokkan menjadi nyamuk endofagik dan nyamuk eksofagik. Tingkat Man Biting Rate (MBR) nyamuk di RW 02 Kelurahan Kamoro Jaya Tahun 2024 adalah 12 Ekor/Orang/Malam. Kepadatan jentik nyamuk Anopheles sp. di RW 02 Kelurahan Kamoro Jaya adalah 2 ekor per area. Indeks Habitat melebihi baku mutu yaitu 16%. Kesimpuan: Nyamuk Anopheles sp terbanyak merupakan nyamuk bersifat eksofagik (suka menggigit di luar rumah) sehingga peru dilakukan edukasi kepada masyarakat terkait aktivitas di luar rumah dan perlu dilakukan pengendalian vektor oleh petugas puskesmas serta masyarakat.
Rethinking research through artistic experimentation
Authors: Cacciatore Silvia , Panozzo Fabrizio
Published: January 2025

The primary objective of this paper is to examine, both theoretically and empirically, two distinct approaches through which artistic research intersects with academia. This examination is undertaken to critically evaluate the paradigmatic tensions arising from the juxtaposition of unfettered artistic exploration and the escalating pressures for demonstrable outcomes, accountability, and process transparency inherent in managerial contexts. Consequently, the theoretical underpinnings of artistic interventions within organizational settings will be explicated, emphasizing the academic community’s exploration and application of such modes of artistic inquiry. Conversely, the approach of art-based research will be delineated, emphasizing its utilization of artistic modalities to investigate phenomena through a scientific lens. Moreover, prominent theories positing academic research as constraining artistic experimentation will be outlined. Finally, drawing upon four case reports conducted within academic environments, a novel method will be proposed to mitigate the encroachment of increasingly institutionalized approaches towards the arts.
Strategies for making artistic research public: a case study of the Uniarts Helsinki Research Pavilion project
Authors: Aavanranta Otso , Elo Mika , Rouhiainen Leena
Published: January 2025

This article presents and discusses the Uniarts Helsinki Research Pavilion project, a biennial platform for developing public outreach of artistic research. Launched in 2015, the Research Pavilion has been iterated five times, three editions in the context of the Venice Biennale and two editions in Helsinki, Finland. Drawing on the experience provided by this long-term commitment to foster public outreach of artistic research, the article discusses central management and policy–related negotiations and issues that have become apparent during the Research Pavilion project. In its first part, the article presents the origin and genealogy of the Research Pavilion project, and briefly outlines the operational framing and contexts of its four first editions. The related theoretical underpinnings concerning the development of artistic research are also addressed. In its second part, the text focuses on the latest, fifth iteration of the Research Pavilion, proceeding to critically analyse its policy framework in terms of the cross-pollination as well as the pushes and pulls between academia and independent arts field, the inclusion of an artist-researcher residency programme within the Research Pavilion, and the underlying ethical issues. The article concludes by suggesting that the tensions and negotiations within the Research Pavilion project may reflect the larger context of artistic research, and it discusses possible further steps within a changing macro-political situation.
Recent advances in innovative biomaterials for promoting bladder regeneration: processing and functionalization
Authors: Zhang Yi , Ding Fu’an , Han Junjie , Wang Zongliang , Tian Wenjie
Published: January 2025

The bladder is a dynamic organ located in the lower urinary tract, responsible for complex and important physiological activities in the human body, including collecting and storing urine. Severe diseases or bladder injuries often lead to tissue destruction and loss of normal function, requiring surgical intervention and reconstruction. The rapid development of innovative biomaterials has brought revolutionary opportunities for modern urology to overcome the limitations of tissue transplantation. This article first summarized the latest research progress in the processing approaches and functionalization of acellular matrix, hydrogels, nanomaterials, and porous scaffolds in repairing and reconstructing the physiological structure and dynamic function of damaged bladder. Then, we discussed emerging strategies for bladder regeneration and functional recovery, such as cell therapy, organoids, etc. Finally, we outlined the important issues and future development prospects of biomaterials in bladder regeneration to inspire future research directions. By reviewing these innovative biomaterials and technologies, we hope to provide appropriate insights to achieve the ultimate goal of designing and manufacturing artificial bladder substitutes with ideal performance in all aspects.
How cells align to structured collagen fibrils: a hybrid cellular Potts and molecular dynamics model with dynamic mechanosensitive focal adhesions
Authors: Keijzer Koen A. E. , Tsingos Erika , Merks Roeland M. H.
Published: January 2025

Many mammalian cells, including endothelial cells and fibroblasts, align and elongate along the orientation of extracellular matrix (ECM) fibers in a gel when cultured in vitro. During cell elongation, clusters of focal adhesions (FAs) form near the poles of the elongating cells. FAs are mechanosensitive clusters of adhesions that grow under mechanical tension exerted by the cells’ pulling on the ECM and shrink when the tension is released. In this study, we use mathematical modeling to study the hypothesis that mechanical reciprocity between cells and the ECM is sufficient for directing cell shape changes and orientation. We show that FAs are preferentially stabilized along the orientation of ECM fibers, where cells can generate higher tension than in directions perpendicular to the ECM fibers. We present a hybrid computational model coupling three mathematical approaches: first, the cellular Potts model (CPM) describes an individual contractile cell; second, molecular dynamics (MD) represent the ECM as a network of cross-linked, deformable fibers; third, a set of ordinary differential equations (ODEs) describes the dynamics of the cell’s FAs, in terms of a balance between assembly and a mechanoresponsive disassembly. The resulting computational model shows that mechanical reciprocity suffices for stiffness-dependent cell spreading, local ECM remodeling, and ECM-alignment-dependent cell elongation. These combined effects are sufficient to explain how cell morphology is influenced by the local ECM structure and mechanics.
Exploring the antifungal potential of Cannabis sativa-derived stilbenoids and cannabinoids against novel targets through in silico protein interaction profiling
Authors: Kırboğa Kevser Kübra , Karim Aman , Küçüksille Ecir Uğur , Rudrapal Mithun , Khan Johra , Achar Raghu Ram , Silina Ekaterina , Manturova Natalia , Stupin Victor
Published: January 2025

Cannabinoid and stilbenoid compounds derived from Cannabis sativa were screened against eight specific fungal protein targets to identify potential antifungal agents. The proteins investigated included Glycosylphosphatidylinositol (GPI), Enolase, Mannitol-2-dehydrogenase, GMP synthase, Dihydroorotate dehydrogenase (DHODH), Heat shock protein 90 homolog (Hsp90), Chitin Synthase 2 (CaChs2), and Mannitol-1-phosphate 5-dehydrogenase (M1P5DH), all of which play crucial roles in fungal survival and pathogenicity. This research evaluates the binding affinities and interaction profiles of selected cannabinoids and stilbenoids with these eight proteins using molecular docking and molecular dynamics simulations. The ligands with the highest binding affinities were identified, and their pharmacokinetic profiles were analyzed using ADMET analysis. The results indicate that GMP synthase exhibited the highest binding affinity with Cannabistilbene I (−9.1 kcal/mol), suggesting hydrophobic solid interactions and multiple hydrogen bonds. Similarly, Chitin Synthase 2 demonstrated significant binding with Cannabistilbene I (−9.1 kcal/mol). In contrast, ligands such as Cannabinolic acid and 8-hydroxycannabinolic acid exhibited moderate binding affinities, underscoring the variability in interaction strengths among different proteins. Despite promising in silico results, experimental validation is necessary to confirm therapeutic potential. This research lays a crucial foundation for future studies, emphasizing the importance of evaluating binding affinities, pharmacokinetic properties, and multi-target interactions to identify promising antifungal agents.
Safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention: a single-center experience
Authors: Wang Huanhuan , Cui Cheng , Liu Dan , Liu Hongmei , Tian Tao , Liu Minghao , Zhang Bo , Zou Tongqiang , Gao Zhan , Gao Lijian , Liu Haibo
Published: January 2025

Aim

To evaluate the safety of brachial artery (BA) sheath removal after heparin neutralization with a half dose of protamine immediately after percutaneous coronary intervention (PCI).

Methods

The clinical data of 209 consecutive patients who underwent PCI through the BA at Fu Wai Hospital between September 2019 and June 2024 were retrospectively collected. In group I, the brachial sheath was removed 4 h after the PCI procedure. In group II, circulating heparin was neutralized with a half dose of protamine sulfate, and the brachial sheath was removed immediately after the procedure.

Results

There were no cases of acute stent thrombosis, nonfatal myocardial infarction or in-hospital mortality in either group. In group II, there were two cases of pseudoaneurysm, one of which was transfer to surgery and the other was manually compressed. No severe puncture site-related bleeding occurred. The levels of hemoglobin were similar between the two groups before and after the PCI procedure (p > 0.05).

Conclusions

The BA sheath can be safely removed immediately after PCI by neutralizing heparin with a half dose of protamine. But we still need to be vigilant about the occurrence of pseudoaneurysms.
Bile acids and incretins as modulators of obesity-associated atherosclerosis
Authors: Kirsch Andrijana , Gindlhuber Juergen , Zabini Diana , Osto Elena
Published: January 2025

Obesity is one of the major global health concerns of the 21st century, associated with many comorbidities such as type 2 diabetes mellitus (T2DM), metabolic dysfunction-associated steatotic liver disease, and early and aggressive atherosclerotic cardiovascular disease, which is the leading cause of death worldwide. Bile acids (BAs) and incretins are gut hormones involved in digestion and absorption of fatty acids, and insulin secretion, respectively. In recent years BAs and incretins are increasingly recognized as key signaling molecules, which target multiple tissues and organs, beyond the gastro-intestinal system. Moreover, incretin-based therapy has revolutionized the treatment of T2DM and obesity. This mini review highlights the current knowledge about dysregulations in BA homeostasis in obesity with a special focus on atherosclerosis as well as athero-modulating roles of incretins and currently available incretin-based therapies.
An early warning system for oil wells based on improved long short-term memory network
Authors: Li Jinman , Zhang Chunsheng , Lin Yang , Liu Yimeng , Jin Qingshuang , Xiao Tianhao , Liu Xiaoqi , Zhang Ying
Published: January 2025

Timely and accurate oil well production warnings are crucial for optimizing oilfield management and enhancing economic returns. Traditional methods for predicting oil well production and early warning systems face significant limitations in terms of adaptability and accuracy. Artificial intelligence offers an effective solution to address these challenges. This study focuses on the ultra-high water cut stage in water-driven medium-to-high permeability reservoirs, where the water cut—defined as the ratio of produced water to total produced fluid—exceeds 90%. At this stage, even small fluctuations in water cut can have a significant impact on oil production, making it a critical early warning indicator. We use statistical methods to classify wells and define adaptive warning thresholds based on their unique characteristics. To further improve prediction accuracy, we introduce a Long Short-Term Memory (LSTM) model that integrates both dynamic and static well features, overcoming the limitations of traditional approaches. Field applications validate the effectiveness of the model, demonstrating reduced false alarms and missed warnings, while accurately predicting abnormal increases in water cut. The early warning system helps guide the adjustment of injection and production strategies, preventing water cut surges and improving overall well performance. Additionally, the incorporation of fracture parameters makes the model suitable for reservoirs with fractures.
Heat stroke-induced Guillain–Barré syndrome: a case report and literature review
Authors: Pang Yang , Li Feijie , Li Si , Yuan Jiaojiao
Published: January 2025

In recent years, there has been an increase in complications related to heat stroke (HS), especially those affecting the neurological system. The co-occurrence of HS and Guillain–Barré syndrome (GBS) is exceptionally rare, with fewer than 15 documented cases. This case report describes a patient who developed GBS following an HS and includes a literature review that highlights the rarity of this neurological complication. This study aimed to increase awareness and aid in clinical decision-making regarding the management of classic HS.
Positive association of triglyceride glucose index and gestational diabetes mellitus: a retrospective cohort study
Authors: Zhang Jie , Fang Xia , Song Zhan , Guo Xue-ke , Lin Dong-mei , Jiang Fei-na , Lin Lin , Cai Zhu-hua
Published: January 2025

Background

Gestational diabetes mellitus (GDM) is a common metabolic disorder with important health implications for both mother and offspring. This study aims to assess the relationship between the Triglyceride Glucose (TyG) index and GDM and explore its clinical significance.

Methods

A retrospective cohort study included 631 singleton pregnant women. The study collected data on the TyG index, glucose levels, and clinical outcomes from all participants. Research objectives were validated using logistic regression analysis and Receiver Operating Characteristic curves.

Results

We found an independent correlation between TyG index and increased risk of GDM, with an odds ratio (OR) of 3.11 (95% confidence interval (CI): 2.09-4.63, P<0.001). The spline model revealed a linear association between TyG index and GDM in early pregnancy (non-linear P=0.748), and the risk of GDM increased with the increase of TyG index. In addition, we found that TyG has high diagnostic performance in predicting GDM, with an AUC value of 0.668. Combined with Age, it can improve predictive performance, with an AUC value of 0.684. Compared to the lower quartile of the TyG index, women in the higher quartile have a higher incidence of premature birth, hypertensive disorders of pregnancy, and intrahepatic cholestasis of pregnancy (ICP). In the GDM group, the TyG index was negatively correlated with 25 (OH) D and TBIL, and positively correlated with FBG, TG, and TC.

Conclusions

The TyG index is strongly linked to the development of GDM and is an independent risk factor for predicting it. Monitoring TyG levels in early pregnancy is valuable for identifying women at high risk for GDM.
Prenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring
Authors: Kaimal Amrita , Hooversmith Jessica M. , Al Mansi Maryam H. , Cherry Ariana D. , Garrity Jillian T. , Holmes Philip V. , MohanKumar Puliyur S. , MohanKumar Sheba M. J.
Published: January 2025

Significance

Women are at increased risk for mood disorders, which may be partly attributed to exposure to endocrine-disrupting chemicals (EDCs) during sensitive periods such as pregnancy. Exposure during these times can impact brain development in the offspring, potentially leading to mood disorders in later life. Additionally, fluctuating levels of endogenous estrogens, as seen during pregnancy, or the use of oral contraceptives, can further elevate this risk. This study examines the cumulative effects of prenatal EDC exposure combined with chronic low-dose 17β-estradiol (E2) treatment in adulthood on neurobehavioral outcomes.

Methods

Pregnant Sprague-Dawley rats were orally dosed with vehicle, bisphenol A (BPA) (5 μg/kg body weight (BW)/day), low-dose (LD) diethylhexyl phthalate (DEHP) (5 μg/kg BW/day), high-dose (HD) DEHP (7.5 mg/kg BW/day), or a combination of the two (BPA+DEHP) from gestational days 6-21. At 3 months of age, female offspring were implanted with slow-release E2 pellets or were sham-implanted. Following a 90-day treatment period, behavioral testing was conducted, and serum hormones and brain monoamine levels were analyzed.

Results

Chronic E2 treatment in controls increased anxiety and reduced active coping behaviors. In DEHP- and BPA+DEHP-exposed offspring, E2 treatment reversed some of these effects. Dose-dependent alterations in circulating hormone levels and brain monoamines were observed. Dysregulation of the stress axis was particularly notable with the higher dose of DEHP.

Conclusions

Overall, prenatal EDC exposure altered behavior, hormones, and brain monoamines, with adult E2 treatment further exacerbating some of these effects in female offspring.
Organic iron at ultralow doses catalyzes hydrogen peroxide to eliminate cyanobacterial blooms: a study on algicidal effects and mechanisms under natural conditions
Authors: Lin Yongdong , Niu Ziru , Li Juan , Li Sijin , Li Hai , Li Lei
Published: January 2025

Hydrogen peroxide (H2O2) is gaining recognition as an eco-friendly and highly effective algicide for combating cyanobacterial blooms. This study investigates the algicidal potential of H2O2 catalyzed by both inorganic and organic iron. Our findings indicate that inorganic iron (FeSO4) shows minimal catalytic activity on H2O2 under varying light conditions. In contrast, organic iron, specifically the combination of H2O2, EDTANaFe, and light irradiation, demonstrates significant algicidal effects. The optimal dosages were identified as 10 mg/L for H2O2 and 3 mg/L for Fe3+.The limited efficacy of inorganic iron stems from the transformation of Fe2+ to Fe3+ ions via the Fenton reaction. Under neutral conditions, Fe3+ ions precipitate as large-sized goethite, which adheres to the extracellular polymeric substances (EPS) of cyanobacterial cells, thereby hindering H2O2 catalysis and hydroxyl radical (·OH) formation in natural waters. Conversely, the combination of light radiation and organic iron salts greatly enhances the algicidal efficiency of H2O2. This synergy accelerates H2O2 decomposition and facilitates the production of a substantial amount of OH radicals by altering the Gibbs free energy. Thus, bright and sunny conditions, particularly in the afternoon, are crucial for effectively combating cyanobacterial blooms using Fenton-like reagents. The methodology presented in this study offers a viable solution to global cyanobacteria bloom issues and elucidates the mechanisms driving its efficacy.
The role of technological innovation and institutional quality in environmental and economic growth sustainability in emerging Asian countries
Authors: Zhang Ruiyue , Jing Liu , Li Yutong , Guo Xu
Published: January 2025

Economic activities based on primary industrial operations and fossil fuel energy cause environmental pollution by releasing carbon dioxide that is harmful to the environment. Green technological innovation and institutional quality are considered important tools to reduce environmental emission levels and promote economic growth. However, there are few studies that explore the role of technological innovation and institutional quality in exacerbating environmental pollution from the perspective of emerging Asian countries. Thus, this study unveils the influence of green technology innovation, institutional quality, renewable energy use and non-renewable energy use on per capita carbon emissions and per capita economic growth in emerging Asian countries from 1995 to 2022. The current study uses second-generation augmented mean group and common correlated effects mean group panel methods, taking into account residual cross-sectional dependence and heterogeneity to reveal long term relationship between dynamics. The analysis results emphasize that every 1% expansion of technological innovation can strongly reduce per capita carbon dioxide emissions by 0.329%, while effectively boosting per capita economic growth by 0.397%. However, every 1% improvement in institutional quality can effectively promote per capita carbon dioxide emissions and per capita economic growth by 0.243% and 0.362% respectively. Moreover, renewable energy strongly reduces environmental emissions and promotes economic enhancement, while non-renewable energy considerably stimulates environmental pollution and economic progress. Based on the revealed exploration, this study recommends that emerging markets in Asia should strengthen their respective institutional quality to focus on investing in green technology innovation and renewable energy projects to achieve sustainable development goals.
VHRTrees: a new benchmark dataset for tree detection in satellite imagery and performance evaluation with YOLO-based models
Authors: Topgül Şule Nur , Sertel Elif , Aksoy Samet , Ünsalan Cem , Fransson Johan E. S.
Published: January 2025

Natural and planted forests, covering approximately 31% of the Earth’s land area, are crucial for global ecosystems, providing essential services such as regulating the water cycle, soil conservation, carbon storage, and biodiversity preservation. However, traditional forest mapping and monitoring methods are often costly and limited in scale, highlighting the need to develop innovative approaches for tree detection that can enhance forest management. In this study, we present a new dataset for tree detection, VHRTrees, derived from very high-resolution RGB satellite images. This dataset includes approximately 26,000 tree boundaries derived from 1,496 image patches of different geographical regions, representing various topographic and climatic conditions. We implemented various object detection algorithms to evaluate the performance of different methods, propose the best experimental configurations, and generate a benchmark analysis for further studies. We conducted our experiments with different variants and hyperparameter settings of the YOLOv5, YOLOv7, YOLOv8, and YOLOv9 models. Results from extensive experiments indicate that, increasing network resolution and batch size led to higher precision and recall in tree detection. YOLOv8m, optimized with Auto, achieved the highest F1-score (0.932) and mean Average Precision (mAP)@0.50 Intersection over Union threshold (0.934), although some other configurations showed higher mAP@0.50:0.95. These findings underscore the effectiveness of You Only Look Once (YOLO)-based object detection algorithms for real-time forest monitoring applications, offering a cost-effective and accurate solution for tree detection using RGB satellite imagery. The VHRTrees dataset, related source codes, and pretrained models are available at https://github.com/RSandAI/VHRTrees.
A genome-wide association study identified candidate regions and genes for commercial traits in a Landrace population
Authors: Ma Guojian , Tan Xihong , Yan Ying , Zhang Tianyang , Wang Jianhua , Chen Xiaoling , Xu Jingya
Published: January 2025

Backfat thickness (BFT) and feed conversion ratio (FCR) are important commercial traits in the pig industry. With the increasing demand for human health and meat production, identifying functional genomic regions and genes associated with these commercial traits is critical for enhancing production efficiency. In this research, we conducted a genome-wide association study (GWAS) on a Landrace population comprising 4,295 individuals with chip data for BFT and FCR. Our analysis revealed a total of 118 genome-wide significant signals located on chromosomes SSC1, SSC2, SSC7, SSC12, and SSC13, respectively. Furthermore, we identified 10 potential regions associated with the two traits and annotated the genes within these regions. In addition, enrichment analysis was also performed. Notably, candidate genes such as SHANK2, KCNQ1, and ABL1 were found to be associated with BFT, whereas NAP1L4, LSP1, and PPFIA1 genes were related to the FCR. Our findings provide valuable insights into the genetic architecture of these two traits and offer guidance for future pig breeding efforts.
The effect of HLA genotype on disease onset and severity in CTLA-4 insufficiency
Authors: Posadas-Cantera Sara , Mitsuiki Noriko , Emmerich Florian , Patiño Virginia , Lorenz Hanns-Martin , Neth Olaf , Dybedal Ingunn , Taskén Kjetil , Schäffer Alejandro A. , Grimbacher Bodo , Gámez-Díaz Laura
Published: January 2025

Introduction

Human Cytotoxic-T-lymphocyte-antigen-4 (CTLA-4) insufficiency caused by heterozygous germline mutations in CTLA4 is a complex immune dysregulation and immunodeficiency syndrome presenting with reduced penetrance and variable disease expressivity, suggesting the presence of disease modifiers that trigger the disease onset and severity. Various genetic and non-genetic potential triggers have been analyzed in CTLA-4 insufficiency cohorts, however, none of them have revealed a clear association to the disease. Multiple HLA haplotypes have been positively or negatively associated with various autoimmune diseases and inborn errors of immunity (IEI) due to the relevance of MHC in the strength of the T cell responses.

Methods

In this exploratory study, we investigated the association of disease onset, severity and clinical manifestations of CTLA-4 insufficiency with specific HLA class I (A, B and C) and class II (DRB1 and DQB1) alleles in forty-three individuals harboring heterozygous mutations in CTLA4. Twenty-six out of the 43 recruited individuals presented moderate or severe clinical symptoms whereas 17 were completely healthy. HLA frequency analysis, odds ratio analysis and genetic linkage analysis were used.

Results

The principal statistical analyses showed no positive association between the HLA genotypes analyzed with the disease onset or the disease severity. We found potential risk associations of HLA-DQB1*05:01 and HLA-DRB1*01:02 with respiratory tract involvement and HLA-C*05:01 with affection of the neurological system in the CTLA-4-insufficient patients. Additionally, we found a potential protective association of HLA-DRB1*01:01 with gastrointestinal symptoms.

Discussion

Even though, our findings suggest that HLA-A, -B, -C, DRB1, and DQB1 do not contribute to the onset or severity of disease in CTLA-4 insufficiency, certain HLA-alleles may influence the manifestation of specific symptoms. We advocate for further investigation of specific class I and class II HLA alleles as potential disease modifiers in larger clinical cohorts of CTLA-4 insufficiency.