bluuebunny/crossref_metadata_2025 huggingface dataset:
Standardization of Panax ginseng: Current Status of Global Trade, Demands, and Development
Authors: Fan Jia-Wei , Xu Xiao-Ting , Cheng Han , Sang Zhen , Shi Yan-Hong
Published: April 2023

Panax ginseng, as a kind of rare and valuable Chinese materia medica with the largest global trade volume, has been widely applied in many fields, such as medicine, food, health care, and production of daily chemical products. It is widely used in Asia, Europe, and America. However, its global trade and standardization present different features and an uneven development in different countries or regions. As the main country for its production and consumption, Panax ginseng in China is characterized by its large cultivation area and high total yield and is mainly sold as a raw material or primary processed product. By contrast, Panax ginseng produced in South Korea is mainly sold in manufactured products. Besides, European countries, as another consumption market of Panax ginseng, pay more attention to the research and development of its products. Although Panax ginseng has been widely recorded in various national pharmacopoeias and regional standards, the current standards of Panax ginseng differ in quantity, composition, and distribution, and the existing standards cannot be enough to meet the demands of its global trade. Based on the above issues, we systemically summarized and analyzed the status and features of Panax ginseng standardization and put forward suggestions on the development needs of international standardization of Panax ginseng to guarantee its quality and safety, regulate the order of its global trade, and resolve trade disputes, thereby promoting the high-quality development of the Panax ginseng industry.
Solar system physical treatment using a turbulator and nanomaterial through absorber duct
Authors: Ajour Mohammed N. , Rawa Muhyaddin J. H. , Milyani Ahmad H. , Li Meicheng
Published: April 2023

A three-part tape-enhanced tube was used in the current hypothetical solar unit to save the most radiation possible. The three parts were joined at different angles ([Formula: see text]). The parameters of the carrier base fluid after mixing with CuO nanopowder were calculated using a homogeneous model. By adjusting the range of Y[Formula: see text], multiple layers were used to precisely depict the behavior of flow close to the wall. The results show the components of irreversibility as bar charts, velocity contours, and exergy drop contours. The tape angle ([Formula: see text]) and inlet velocity were thought to be the main driving forces. An evaluation of the accommodation’s validity using numerical data shows that it is sufficient. The wall temperature decreases by about 0.0257% as the nanofluid angle rises and more collisions with the wall take place. Xd falls off roughly 5.19% from 0∘ to 45∘ and 5.87% from 0∘ to 90∘ as the angle [Formula: see text] rises. As [Formula: see text] rises, the entropy of friction increases by 9.88%. The outer wall cools by about 0.87% and Xd falls by about 92.3% when [Formula: see text] and Re rises.
Disentangling Hype from Practicality: On Realistically Achieving Quantum Advantage
Authors: Hoefler Torsten , Häner Thomas , Troyer Matthias
Published: April 2023

What are the promising applications to realize quantum advantage?
Unlocking the Potential of Fully Homomorphic Encryption
Authors: Gorantala Shruthi , Springer Rob , Gipson Bryant
Published: April 2023

Exploring the transformational potential of FHE and the path toward adoption of its "stack."
A Reconfigurable Architecture for Real-time Event-based Multi-Object Tracking
Authors: Gao Yizhao , Wang Song , So Hayden Kwok-Hay
Published: April 2023

Although advances in event-based machine vision algorithms have demonstrated unparalleled capabilities in performing some of the most demanding tasks, their implementations under stringent real-time and power constraints in edge systems remain a major challenge. In this work, a reconfigurable hardware-software architecture called REMOT, which performs real-time event-based multi-object tracking on FPGAs, is presented. REMOT performs vision tasks by defining a set of actions over attention units (AUs). These actions allow AUs to track an object candidate autonomously by adjusting its region of attention and allow information gathered by each AU to be used for making algorithmic-level decisions. Taking advantage of this modular structure, algorithm-architecture codesign can be performed by implementing different parts of the algorithm in either hardware or software for different tradeoffs. Results show that REMOT can process 0.43–2.91 million events per second at 1.75–5.45 W. Compared with the software baseline, our implementation achieves up to 44 times higher throughput and 35.4 times higher power efficiency. Migrating the Merge operation to hardware further reduces the worst-case latency to be 95 times shorter than the software baseline. By varying the AU configuration and operation, a reduction of 0.59–0.77 mW per AU on the programmable logic has also been demonstrated.
Adaptive Thiele interpolation
Authors: Celis Oliver Salazar
Published: April 2023

The current implementation of Thiele rational interpolation in Maple (the Thieleinterpolation routine) breaks down when the points are not well-ordered. In this article, it is shown how this breakdown can be avoided by ordering the interpolation points in an adaptive way.
P4RROT: Generating P4 Code for the Application Layer
Authors: Györgyi Csaba , Laki Sándor , Schmid Stefan
Published: April 2023

Throughput and latency critical applications could often benefit of performing computations close to the client. To enable this, distributed computing paradigms such as edge computing have recently emerged. However, with the advent of programmable data planes, computations cannot only be performed by servers but they can be offloaded to network switches. Languages like P4 enable to flexibly reprogram the entire packet processing pipeline. Though these devices promise high throughput and ultra-low response times, implementing application-layer tasks in the data plane programming language P4 is still challenging for an application developer who is not familiar with networking domain. In this paper, we first identify and examine obstacles and pain points one can experience when offloading server-based computations to the network. Then we present P4rrot, a code generator (in form of a library) which allows to overcome these limitations by providing a user-friendly API to describe computations to be offloaded. After discussing the design choices behind P4rrot, we introduce our proof-of-concept implementation for two P4 targets: Netronome SmartNIC and BMv2. To demonstrate the applicability of P4rrot, we investigate case studies in the context of publish-subscribe sensor data processing and real-time data streaming, supporting, in particular, MQTT-SN and MoldUDP packets.
Automating Library Migrations with Error Prone and Refaster
Authors: Ossendrijver Rick , Schroevers Stephan , Grelck Clemens
Published: April 2023

Software projects use a significant number of external libraries to speed up development and deliver high-quality software in a cost-effective way. Requirements placed on external libraries can change over time and libraries may cease to be maintained or evolve in incompatible ways. Consequently, a library may no longer be fit for purpose and require replacement. Such a
library migration
is generally performed manually and may be complex, error-prone, and time-consuming, especially for large codebases. It follows that an automated approach to library migrations is preferred.

We consider the suitability of Error Prone and Refaster, two Google tools capable of refactoring Java programs, for automated library migration. For validation we consider a migration in a proprietary industrial codebase as well as an actively developed open source codebase. We show that using out-of-the-box Error Prone and Refaster full migration of RxJava 2-referencing files is possible in only 35% and 0% of such files, respectively.

To increase the capabilities and be able to migrate more Rx-Java 2-referencing files completely, we create extensions to Error Prone and Refaster. Therefore we propose and create extensions that improve the accuracy with which Refaster templates are matched, as well as the correctness of their replacement operations. We additionally propose a set of Error Prone extensions to facilitate rewriting method return types. Together they enable a new class of rewrite operations especially relevant to library migrations. Lastly, several generalizations and improvements of existing Error Prone plugins are discussed. Together these improvements enable a new class of rewrite operations, especially relevant to library migrations. Using the proposed extensions, we manage to fully migrate an additional 35% of the RxJava 2-referencing files in the industrial codebase, and an initial 39% of such files in the open source codebase.
Heterogeneously Functionalized Electrode Materials for Energy Conversion and Storage Processes
Authors: Chen Tse-Wei , Ramachandran Rasu , Veerakumar Pitchaimani , Chen Shen-Ming , Veeraraghavan Vishnu Priya , Mariyappan Vinitha , Kannan Ramanujam , Raja Paulsamy
Published: April 2023

Heterogeneous based functionalized nanocomposite materials have attracted considerable attention in both energy storage and conversion process, due to their fast electron transfer process and their ling-life cycles. Herein, the review briefly discussed different kinds of techniques, which are used for the fabrication of carbon based nanocomposites like sol-gel, hydrothermal (HT), in situ polymerization and electrochemical methods, etc In particularly, functionalized carbon decorated nanocomposites have been focused on the designing and development of rational candidate for future energy technologies. Especially, the highlighted nanocomposites have become more attention in the area of energy technologies mainly caused by their larger electrode surface area, high mechanical strength, excellent electrochemical properties, and rapid electrochemical redox behaviour. Considerable advancements in the combinations of nanoscale based composite devices have the platforms to develop new energy storage technology to fulfill the global energy demands. Finally, it summarizes the recent advantages of carbon supported composite, which significantly enhanced their electrochemical energy storage devices properties like high capacitance and boosted specific capacitive values.
Facile Preparation of V2O5 Hollow Microspheres with Mesoporous on the Shell and Their Electrochemical Properties for Lithium-Ion Batteries
Authors: Dong Xuelu , Dong Fangyuan , Zhu Keke , Li Haibo , Zeng Suyuan , Cui Chuansheng , Fu Chonggang , Wang Lei
Published: April 2023

In this work, vanadium pentoxide (V2O5) hollow microspheres with mesoporous on the shell were prepared by a solvothermal process followed by a high-temperature calcination step in air. The as-prepared hollow microspheres exhibit the mesoporous structure on the shells, which provide channels for electrolyte transfer and show excellent lithium storage properties for lithium-ion batteries. The electrochemical performances of formed V2O5 porous-hollow microsphere anodes were investigated and analyzed. Among the formed samples, integral V2O5 hollow microspheres with mesoporous on the shell achieved a reversible capacity of 710.2 mA h g−1 after 400 cycles at a current density of 0.5 A g−1. The results demonstrate an ascendant electrochemical characteristic of as-prepared V2O5 hollow microspheres with mesoporous on the shell for the energy storage devices.
Extracellular Electron Transfer of Weak Electricigens in the Presence of a Competing Electron Acceptor
Authors: Aiyer Kartik , Doyle Lucinda E.
Published: April 2023

To maximise microbial electroactivity in bioelectrochemical systems, soluble electron acceptors are typically omitted as they compete with the electrode. While practical, this approach provides engineered conditions that do not reflect the natural environment of electroactive microorganisms, which may contain both soluble and insoluble electron acceptors. This study investigates the behaviour of weak electricigens, a relatively understudied category of microorganisms whose members switch between non-electroactive and electroactive states. Enrichments were performed in microbial fuel cells containing both an electrode and the soluble alternative fumarate to probe extracellular electron transfer of weak electricigens. Using fluorescence spectroscopy, chromatography and voltammetry, the electron shuttle riboflavin was not found in these conditions but was found in controls in which only the electrode was available to reduce. Despite this dichotomy in ability to perform riboflavin-based mediated electron transfer, communities of weak electricigens were similarly electroactive in each condition (19.36 ± 0.9 mW m−2 vs 20.25 ± 2.0 mW m−2). 16S rRNA gene sequencing revealed similar communities enriched in each condition, but with differing abundance. Understanding extracellular electron transfer in natural environments is of both fundamental and applied interest, as it can inform the design of real-world bioelectrochemical systems whose influents are likely to contain competing electron acceptors.
The TMEM43 S358L mutation affects cardiac, small intestine, and metabolic homeostasis in a knock-in mouse model
Authors: Orgil Buyan-Ochir , Munkhsaikhan Undral , Pierre Joseph F. , Li Ning , Xu Fuyi , Alberson Neely R. , Johnson Jason N. , Wetzel Glenn T. , Boukens Bastiaan J. D. , Lu Lu , Towbin Jeffrey A. , Purevjav Enkhsaikhan
Published: April 2023

This manuscript describes the findings of our investigation of cardiac, small intestine, and metabolic features of Tmem43-S358L mouse model. By investigating interorgan pathologies, we uncovered multiple mechanisms of the S358L-induced disease, and these unique mechanisms likely appear to contribute to the disease pathogenesis. We hope our findings are important and novel and open new avenues in the hunting for additional diagnostic and therapeutic targets in subjects carrying TMEM43 mutation.
Working towards the Active Participation of Underrepresented Populations in Research: A Scoping Review and Thematic Synthesis
Authors: Gallegos D. , Durham J. , Rutter C. , McKechnie R.
Published: April 2023

Research has historically focussed on participants who are relatively easy to access; those who have resources (time and literacy) to respond to surveys, who can travel, and are socially connected. Failure to meaningfully engage with intended participants and achieve representativeness in participation risks diminishing the applicability and impact of research findings to local contexts. Motivated by goals of social justice and health equity, this scoping review sought to identify strategies to effectively engage and integrate the “authentic voice” of populations that are described as vulnerable or precarious and therefore perceived as “hard-to-reach.” A system tic search strategy identified 34 eligible papers. Articles underwent (i) a title and abstract screening by two reviewers, followed by (ii) a full text review of eligible articles by one author. Free-form research problem mind-mapping was applied to facilitate analysis and generate creative associations between ideas. Thematic and content analysis was then applied to generate themes and subthemes. Four high-level themes emerged: key players, trust and rapport, navigating structural precarity, and moving beyond “participation.” We identified that substantial shifts in researcher mindsets are required to reframe perceptions of vulnerability and move towards strengths-based approaches. Efforts need to be directed towards establishing deep trust and rapport through early engagement and social reciprocity. Systemic barriers to research participation and partnership must be addressed to overcome issues of structural precarity. We urge researchers and practitioners to embrace “scholar activism” and to actively dismantle the precarity that limits active “participation” and to build deliberate strategies to create forums where the “authentic” voice can be amplified.
An Unusual Case of a Perforated Meckel’s Diverticulum
Authors: Mendoza Alvarez Lybil , Rajderkar Dhanashree , Beasley Genie L.
Published: April 2023

Background. Meckel’s diverticulum, the most common congenital anomaly of the gastrointestinal tract, typically presents in children with gastrointestinal bleeding. Case Presentation. An 11-year-old Caucasian male presented with a 6 week history of abdominal pain, vomiting, and diarrhea. He was found to have iron deficiency anemia, markedly elevated serum and fecal inflammatory markers, and imaging showing a contained bowel perforation. He was evaluated for infectious etiologies and later underwent extensive testing for inflammatory bowel disease. Ultimately, he was found to have a Meckel’s diverticulum, which was successfully resected and led to resolution of his gastrointestinal complaints. Conclusions. This case report highlights one of the more rare presentations in children, which is intestinal perforation. Symptoms of a Meckel’s diverticulum can overlap with those of inflammatory bowel disease, as demonstrated by our patient. Clinicians should be familiar with criteria to establish diagnosis of inflammatory bowel disease, and if diagnosis isn’t fully supported by testing, they should expand the differential and consider Meckel’s diverticulum.
A Semianalytical Mathematical Model and Seepage Characteristics of Off‐Center Fractured Vertical Wells with Multiwing Asymmetrical Fractures
Authors: Ji Anzhao , Wang Yufeng , Xu Youjie , Zhang Guangsheng , Liu Xuefen
Published: April 2023

The complexity of formation conditions leads to multiwing asymmetric fractures after large‐scale fracturing. According to a well pattern model and reservoir characteristics, a testing well is away from the center of the reservoir, and the existing well‐test mathematical model cannot meet the field data analysis demand. Therefore, the mathematical model for the fractured wells with multiwing asymmetrical fractures is established. The model solution of the Laplace domain is obtained by the Laplace transform, nonuniform fracture discretization, and pressure drop superposition principle. The model is compared with the numerical model in this paper, and the result shows that the presented semianalytical model and the calculation method are correct. The eight main flow stages are divided according to pressure derivative characteristics and the seepage process of off‐center fractured vertical wells with multiwing asymmetrical fractures. The larger off‐center distance will lead to higher pressures and derivative curves. Larger fracture asymmetry factors are higher pressures and derivative curves during bilinear and linear flow regimes. The field data show that the model is applicable and that the model can give the guidance of fractured well formation evaluation.
Intraclass Switching among IL17 Inhibitors in Psoriasis: A Real‐Life, Long‐Term Single‐Center Experience
Authors: Cavallo Francesco , Borriello Silvia , Mastorino Luca , Dapavo Paolo , Quaglino Pietro , Ribero Simone
Published: April 2023

Interleukin 17 (IL‐17) inhibitors such as secukinumab, ixekizumab, and IL17 receptor (IL17RA) inhibitor brodalumab have proved to be highly effective and safe in psoriasis treatment. Still, a substantial proportion of patients show a primary or secondary inefficacy. When this happens, the clinician can change the therapeutical axis (swap) or perform an intraclass switch among IL‐17 inhibitors. The latter option could allow us to address some comorbidity better, spare the other axis in case of the future inefficacy, and avoid interacting with other molecules with a different safety profile. To date, no sufficient data are available on the efficacy of a second IL‐17 inhibitor therapy. Our study included 29 patients with moderate to severe psoriasis undergoing an intraclass switch among IL‐17 inhibitors. The mean PASI dropped from 11.1 ± 6.1 to 5.2 ± 6.6 at week 16, with response maintained at week 28 and week 52 (3.4 ± 4.2 and 3.0 ± 4.3, respectively) with no occurrence of serious adverse events. Our data support the evidence that intraclass switch among IL‐17 inhibitors is a safe and effective therapeutic option in these patients. This trial is registered with SS_DERMO_20.
A New Bayesian Network-Based Generalized Weighting Scheme for the Amalgamation of Multiple Drought Indices
Authors: Raza Muhammad Ahmad , Almazah Mohammed M. A. , Al-ansari Nadhir , Hussain Ijaz , Al-Duais Fuad S. , Naser Mohammed A.
Published: April 2023

Drought is one of the most multifaceted hydrologic phenomena, affecting several factors such as soil moisture, surface runoff, and significant water shortages. Therefore, monitoring and assessing drought occurrences based on a single drought index are inadequate. The current study develops a multiscalar weighted amalgamated drought index (MWADI) to amalgamate multiple drought indices. The MWADI is mainly based on the normalized average dependence posterior probabilities (ADPPs). These ADPPs are obtained from Bayesian networks (BNs)-based Markov Chain Monte Carlo (MCMC) simulations. Results have shown that the MWADI correlates more with the standardized precipitation index (SPI) and the standardized precipitation temperature index (SPTI). As proposed, the MWADI synthesizes drought characteristics of different multiscalar drought indices to reduce the uncertainty of individual drought indices and provide a comprehensive drought assessment.
Stress-Strain Relationship of Clay in Dongting Lake Area Based on Three Damage Factors
Authors: Chen Qiu-Nan , Xu Xiao-Di , Yang Zhen-Yu , Ma Bin-Hui , Hu Wei , He Yong-Chao , Huang Xiao-Cheng , Lei Yong
Published: April 2023

CU test and CD test were performed to capture the stress-strain characteristics of the clay in Dongting Lake area, China. Since the classical constitutive model cannot ideally describe the strain hardening behavior of the clay, an improved constitutive model that involved three damage factors was proposed. The damage first factor

D

1

, which represents elemental volume strength

F

, was fitted by the Weibull function. The second and third damage factors

D

2

and

D

3

, which represent the porosity ratio

e

and the drainage rate

P

ε

respectively, were fitted by Harris function. The CD test damage model is constructed by

D

1

,

D

2

, and

D

3

. In the CU test, the porosity ratio

e

is a constant value, and the drainage volume is 0, so that

D

2

is constant value and

D

3

is 0. Therefore, the CU test damage model of the clay was constructed using the damage first factor

D

1

. In the end, the accuracy of the proposed CU/CD damage constitutive models of the clay was validated with the experimental results. It is found that the results fitted by the proposed methodology are in good agreement with the experimental results.
Study on Gain Regularity of High Power Microwave Obtained by Using Path Encoding Pulse Compression
Authors: Fang Jinyong , Zhai Chang , Wu Jiangniu , Zhang Haoliang , Huang Huijun , Batani Dimitri
Published: April 2023

This study is the further research of the path encoding pulse compression technique. In this study, the regularity of pulse compression gain is studied by adopting the numerical simulation and experiment measurement methods. For the lossless cavity, the power gain has the characteristic of equal pulse length with equal compression gain contribution according to the numerical simulation results. It means that the pulse compression gain is increased linearly along with the time length of the input pulse. The obtained pulse power gains are equal for the two subpulses intercepted arbitrarily form the input pulse with equal time length for the pulse compression. For the lossy cavity, the power gain usually does not increase significantly after the length of input pulse reaches to a certain value. The gain contribution decreases gradually along with the increase of time length of input pulse until the growth rate of gain contribution equals to zero. Assuming two subpulses with equal time length were intercepted from the input pulse, the gain contribution of the earlier subpulse is lower than that of the later subpulse. The measured results verified the simulated gain contribution regularity according to the established experimental system.
Supplementary Data from Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc− Activity
Authors: McCormick Patrick N. , Greenwood Hannah E. , Glaser Matthias , Maddocks Oliver D.K. , Gendron Thibault , Sander Kerstin , Gowrishankar Gayatri , Hoehne Aileen , Zhang Tong , Shuhendler Adam J. , Lewis David Y. , Berndt Mathias , Koglin Norman , Lythgoe Mark F. , Gambhir Sanjiv S. , Årstad Erik , Witney Timothy H.
Published: April 2023

Supplementary Data from Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc− Activity
Supplemental Table 7 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors
Authors: Gonzalez Nicole , Rao Nina , Dean Michael , Lee Donghyuk , Hurson Amber N. , Baris Dalsu , Schwenn Molly , Johnson Alison , Prokunina-Olsson Ludmila , Friesen Melissa C. , Zhu Bin , Rothman Nathaniel , Silverman Debra T. , Koutros Stella
Published: April 2023

Cosine similarities for all signatures
Supplemental Table 5 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors
Authors: Gonzalez Nicole , Rao Nina , Dean Michael , Lee Donghyuk , Hurson Amber N. , Baris Dalsu , Schwenn Molly , Johnson Alison , Prokunina-Olsson Ludmila , Friesen Melissa C. , Zhu Bin , Rothman Nathaniel , Silverman Debra T. , Koutros Stella
Published: April 2023

REC and nitro-PAH signatures in New England
Supplemental Table 4 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors
Authors: Gonzalez Nicole , Rao Nina , Dean Michael , Lee Donghyuk , Hurson Amber N. , Baris Dalsu , Schwenn Molly , Johnson Alison , Prokunina-Olsson Ludmila , Friesen Melissa C. , Zhu Bin , Rothman Nathaniel , Silverman Debra T. , Koutros Stella
Published: April 2023

specific TP53 mutations and ever diesel
Supplemental Table 2 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors
Authors: Gonzalez Nicole , Rao Nina , Dean Michael , Lee Donghyuk , Hurson Amber N. , Baris Dalsu , Schwenn Molly , Johnson Alison , Prokunina-Olsson Ludmila , Friesen Melissa C. , Zhu Bin , Rothman Nathaniel , Silverman Debra T. , Koutros Stella
Published: April 2023

study characteristics
Supplementary Table 4 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: April 2023

Supplementary Table 4: Multivariable competing-risks regression model for the prediction of death of CVD causes and CAD causes
Supplementary Table 3 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: April 2023

Supplementary Table 3: Sensitivity analyses by Cox regression considering additional covariates
Supplementary Table 15 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: April 2023

Supplementary Table 15: Cox regression analyses evaluating the effect of mosaic chromosomal alterations on the risk of any cause of death by cancer type
Supplementary Table 12 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: April 2023

Supplementary Table 12: Cox regression analyses of the effect of mosaic chromosomal alterations on the risk of death of cardiovascular disease causes per cancer type
Supplementary Table 1 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: April 2023

Supplementary Table 1: Primary diagnostic codes for selected cancers
Table S6 from Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Authors: Li Wanxin , Zhou Xuan , Yuan Shuai , Wang Lijuan , Yu Lili , Sun Jing , Chen Jie , Xiao Qian , Wan Zhongxiao , Zheng Ju-Sheng , Zhang Cai-Xia , Larsson Susanna C. , Farrington Susan M. , Law Philip , Houlston Richard S. , Tomlinson Ian , Ding Ke-Feng , Dunlop Malcolm G. , Theodoratou Evropi , Li Xue
Published: April 2023

Table S6 shows the forward MR analyses of 24 gut microbiota with the risk of colorectal cancer.
Table S4 from Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Authors: Li Wanxin , Zhou Xuan , Yuan Shuai , Wang Lijuan , Yu Lili , Sun Jing , Chen Jie , Xiao Qian , Wan Zhongxiao , Zheng Ju-Sheng , Zhang Cai-Xia , Larsson Susanna C. , Farrington Susan M. , Law Philip , Houlston Richard S. , Tomlinson Ian , Ding Ke-Feng , Dunlop Malcolm G. , Theodoratou Evropi , Li Xue
Published: April 2023

Table S4 shows the SNPs for colorectal cancer.
Supplementary Methods from Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Authors: Li Wanxin , Zhou Xuan , Yuan Shuai , Wang Lijuan , Yu Lili , Sun Jing , Chen Jie , Xiao Qian , Wan Zhongxiao , Zheng Ju-Sheng , Zhang Cai-Xia , Larsson Susanna C. , Farrington Susan M. , Law Philip , Houlston Richard S. , Tomlinson Ian , Ding Ke-Feng , Dunlop Malcolm G. , Theodoratou Evropi , Li Xue
Published: April 2023

Supplementary Methods shows the formulas for calculating F-statistics.
Data from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors
Authors: Gonzalez Nicole , Rao Nina , Dean Michael , Lee Donghyuk , Hurson Amber N. , Baris Dalsu , Schwenn Molly , Johnson Alison , Prokunina-Olsson Ludmila , Friesen Melissa C. , Zhu Bin , Rothman Nathaniel , Silverman Debra T. , Koutros Stella
Published: April 2023

AbstractBackground:
Diesel exhaust is a complex mixture, including polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs (nitro-PAH), many of which are potent mutagens and possible bladder carcinogens. To explore the association between diesel exposure and bladder carcinogenesis, we examined the relationship between exposure and somatic mutations and mutational signatures in bladder tumors.
Methods:
Targeted sequencing was conducted in bladder tumors from the New England Bladder Cancer Study. Using data on 797 cases and 1,418 controls, two-stage polytomous logistic regression was used to evaluate etiologic heterogeneity between bladder cancer subtypes and quantitative, lifetime estimates of respirable elemental carbon (REC), a surrogate for diesel exposure. Poisson regression was used to evaluate associations between REC and mutational signatures.
Results:
We observed significant heterogeneity in the diesel-bladder cancer risk relationship, with a strong positive association among cases with high-grade, nonmuscle invasive TP53-mutated tumors compared with controls [ORTop Tertile vs.Unexposed, 4.8; 95% confidence interval (CI), 2.2–10.5; Ptrend < 0.001; Pheterogeneity = 0.002]. In muscle-invasive tumors, we observed a positive association between diesel exposure and the nitro-PAH signatures of 1,6-dintropyrene (RR, 1.93; 95% CI, 1.28–2.92) and 3-nitrobenzoic acid (RR, 1.97; 95% CI, 1.33–2.92).
Conclusions:
The relationship between diesel exhaust and bladder cancer was heterogeneous based on the presence of TP53 mutations in tumors, further supporting the link between PAH exposure and TP53 mutations in carcinogenesis. Future studies that can identify nitro-PAH signatures in exposed tumors are warranted to add human data supporting the link between diesel and bladder cancer.
Impact:
This study provides additional insight into the etiology and possible mechanisms related to diesel exhaust-induced bladder cancer.
Supplementary Table S2 from A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
Authors: Ding Nan , You A-Bin , Yang Hu , Hu Guo-Sheng , Lai Chun-Ping , Liu Wen , Ye Feng
Published: April 2023

Table S2: Sequence information for probes and primers used in this article.
Supplementary Figure S5 from A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
Authors: Ding Nan , You A-Bin , Yang Hu , Hu Guo-Sheng , Lai Chun-Ping , Liu Wen , Ye Feng
Published: April 2023

Figure S5: EP300 is lowly expressed in CRC tissues and positively correlated with RERE.
Study Protocol from KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial
Authors: Joensuu Heikki , Wardelmann Eva , Eriksson Mikael , Reichardt Annette , Hall Kirsten Sundby , Schütte Jochen , Cameron Silke , Hohenberger Peter , Sihto Harri , Jost Philipp J. , Lindner Lars H. , Bauer Sebastian , Nilsson Bengt , Kallio Raija , Pesonen Tommi , Reichardt Peter
Published: April 2023

Study protocol
Supplementary Figure S3 from A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
Authors: Ding Nan , You A-Bin , Yang Hu , Hu Guo-Sheng , Lai Chun-Ping , Liu Wen , Ye Feng
Published: April 2023

Figure S3: Representative densitometry graphics of Western blot data.
Supplementary Figure S1 from A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
Authors: Ding Nan , You A-Bin , Yang Hu , Hu Guo-Sheng , Lai Chun-Ping , Liu Wen , Ye Feng
Published: April 2023

Supplementary Figure S1: The parental genes of CircRERE and circPARM1 are lowly expressed in CRC tissues and predict poor prognosis in CRC patients.
Supplementary Table 1 from EIF4A3 Acts on the PI3K–AKT–ERK1/2–P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma
Authors: Yu Wenhao , Liang Jinghui , Fang Tao , Jiang Jin , Zhao Renchang , Li Rongyang , Han Jingyi , Tian Hui
Published: April 2023

Sequence of small interfering RNA
Supplementary Table 6 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: April 2023

Normalized Read Pileup and Differential Enrichment Clusters of MOLM13 H3K27Ac CUT&Tag (6 Hours After Drug Treatment) at Enhancers and Promoters
Supplementary Table 2 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: April 2023

Transcription Factor Enrichment Analysis of MOLM13 Bulk RNA-Seq (24 Hours After Drug Treatment)
Supplementary Table 17 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: April 2023

GSEA of Primary AML Bulk RNA-Seq (24 Hours After Drug Treatment)
Supplementary Table 14 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: April 2023

Regulon Enrichment Analysis of Primary AML Blast Bulk RNA-seq from 681 Patient Samples
Supplementary Table 10 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: April 2023

Correlation of Regulon Enrichment Signatures with MYC Gene Expression in Primary AML
Supplementary Materials and Methods from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: April 2023

Supplementary Materials and Methods
Supplementary Fig. 9 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: April 2023

SPI1 knockdown does not disrupt dual FLT3/LSD1 inhibition synergy.
Supplementary Fig. 8 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: April 2023

Combined FLT3/LSD1 inhibition does not substantially alter myeloid differentiation.
Supplementary Fig. 3 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: April 2023

Epigenetic impact of dual FLT3/LSD1 inhibition.
Supplementary Figure Legend 1 and Supplementary Table 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress
Authors: Sannino Sara , Manuel Allison M. , Shang Chaowei , Wendell Stacy G. , Wipf Peter , Brodsky Jeffrey L.
Published: April 2023

Legend to supplementary figure S1 and Table S1 containing a list of reagents and chemicals used to perform the experiments in the manuscript
Supplementary Fig. 1 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Authors: Yashar William M. , Curtiss Brittany M. , Coleman Daniel J. , VanCampen Jake , Kong Garth , Macaraeg Jommel , Estabrook Joseph , Demir Emek , Long Nicola , Bottomly Daniel , McWeeney Shannon K. , Tyner Jeffrey W. , Druker Brian J. , Maxson Julia E. , Braun Theodore P.
Published: April 2023

Drug synergy between FLT3 and LSD1 inhibitors in FLT3-ITD and FLT3-wildtype cell lines.
Supplementary Figure S4 from Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer
Authors: Lang Liwei , Chen Fanghui , Li Yamin , Shay Chloe , Yang Fan , Dan Hancai , Chen Zhuo G. , Saba Nabil F. , Teng Yong
Published: April 2023

Validation the expression levels of top five most upregulated genes (identified from RNA-seq) in radioresistant CAL27 (A) and HN6 (B) cells using qRT-PCR. *p<0.05; **p<0.01.
Supplementary Figure S3 from Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer
Authors: Lang Liwei , Chen Fanghui , Li Yamin , Shay Chloe , Yang Fan , Dan Hancai , Chen Zhuo G. , Saba Nabil F. , Teng Yong
Published: April 2023

Inhibitory effect of three c-Met inhibitors on c-Met phosphorylation in CAL27 cells. CAL27 cells were treated with 2.5 µM SU11274, foretinib or crizotinib for 24 hours, followed by Western blotting analysis.
Supplementary Figure S2 from Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer
Authors: Lang Liwei , Chen Fanghui , Li Yamin , Shay Chloe , Yang Fan , Dan Hancai , Chen Zhuo G. , Saba Nabil F. , Teng Yong
Published: April 2023

Cell proliferative potential between radioresistant and parental CAL27 and HN6 cells determine by MTT assays three days after incubation.
Data from Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer
Authors: Lang Liwei , Chen Fanghui , Li Yamin , Shay Chloe , Yang Fan , Dan Hancai , Chen Zhuo G. , Saba Nabil F. , Teng Yong
Published: April 2023

Radiotherapy plays an essential role in the treatment of head and neck squamous cell carcinoma (HNSCC), yet radioresistance remains a major barrier to therapeutic efficacy. A better understanding of the predominant pathways determining radiotherapy response could help develop mechanism-informed therapies to improve cancer management. Here we report that radioresistant HNSCC cells exhibit increased tumor aggressiveness. Using unbiased proteome profiler antibody arrays, we identify that upregulation of c-Met phosphorylation is one of the critical mechanisms for radioresistance in HNSCC cells. We further uncover that radioresistance-associated HNSCC aggressiveness is effectively exacerbated by c-Met but is suppressed by its genetic knockdown and pharmacologic inactivation. Mechanistically, the resulting upregulation of c-Met promotes elevated expression of plexin domain containing 2 (PLXDC2) through activating ERK1/2-ELK1 signaling, which in turn modulates cancer cell plasticity by epithelial–mesenchymal transition (EMT) induction and enrichment of the cancer stem cell (CSC) subpopulation, leading to resistance of HNSCC cells to radiotherapy. Depletion of PLXDC2 overcomes c-Met–mediated radioresistance through reversing the EMT progress and blunting the self-renewal capacity of CSCs. Therapeutically, the addition of SU11274, a selective and potent c-Met inhibitor, to radiation induces tumor shrinkage and limits tumor metastasis to lymph nodes in an orthotopic mouse model. Collectively, these significant findings not only demonstrate a novel mechanism underpinning radioresistance-associated aggressiveness but also provide a possible therapeutic strategy to target radioresistance in patients with HNSCC.
Significance:
This work provides novel insights into c-Met-PLXDC2 signaling in radioresistance-associated aggressiveness and suggests a new mechanism-informed therapeutic strategy to overcome failure of radiotherapy in patients with HNSCC.
A Marked Eosinophilic Infiltration in Mucosa Could Be a Better Predictive Factor for Intractable Non-Esophageal Eosinophilic Gastrointestinal Disorders
Authors: Ishihara Shingo , Kuribayashi Shiko , Sato Keigo , Kudo Tomohiro , Yamazaki Setsuo , Inoue Teruki , Hazama Yoichi , Furuya Kensuke , Nakayama Tetsuo , Hachisu Yoko , Marubashi Kyoko , Uraoka Toshio ,   Gunma Gastrointestinal Research Group
Published: April 2023

Introduction: Non-esophageal eosinophilic gastrointestinal disorders (non-EoE EGIDs) are rare, but their prevalence has recently increased. Although it has been reported that one-half of patients with non-EoE EGIDs have intractable clinical courses, their clinical features are not fully understood. Methods: This is a multicenter retrospective study in which 10 institutions in Japan participated. Clinical databases from January 1998 to December 2020 were reviewed to identify patients with non-EoE EGIDs. A total of 44 patients were identified; they were divided into two groups based on their clinical course: an intractable group and a non-intractable group. The clinical features were compared between the two groups by a logistic regression analysis. Remarkable eosinophilic infiltration (REI) was defined histologically when the maximal counts of mucosal eosinophils reached a threshold level in the respective area of biopsy. Results: Prevalence of drug allergy and eosinophil counts more than 500/μL (EOS), vomiting symptoms, abnormalities of the stomach, duodenum, and jejunum on computed tomography (upper gastrointestinal abnormality on computed tomography [UACT]), and REI were significantly different between the two groups. Among the factors that were potentially associated with an intractable clinical course, logistic regression revealed that REI, EOS, and UACT were significant factors. Based on an analysis of the area under the receiver operator characteristic curve, a combination of REI and EOS had the lowest Akaike’s information criterion, indicating the best model to predict an intractable clinical course. Conclusions: REI may predict an intractable course in patients with non-EoE EGIDs. In addition, the combination of REI and EOS was a better predictor than REI alone.
Adrenal Tuberculosis: A Case Report and Literature Review
Authors: Huang Hao , Gao Liang , Li YaDong , Tan Wei , Wu Hao , Yuan Ye , Liu Chuan
Published: April 2023

Adrenal tuberculosis (TB) is a rare disease, which is difficult to diagnose because of its atypical symptoms. We reported a 41-year-old female who was admitted to hospital due to a left adrenal tumor, which was found in health examination without any symptoms. Abdominal CT showed a mass in her left adrenal. The results of blood test were normal. A retroperitoneal laparoscopic adrenalectomy was carried out, and adrenal TB was finally pathologically diagnosed. Following this, examinations focusing on TB were conducted which revealed negative results except for T-cell enzyme-linked immunospot. After the operation, the hormone level was normal. However, a wound infection occurred, which was recovered after antituberculosis treatment. In conclusion, even if there is no evidence of TB, we should be alert when diagnosing adrenal masses. Examinations of pathology, radiography, and hormone play important roles in determining the definite diagnosis of adrenal TB.