bluuebunny/crossref_metadata_2025 huggingface dataset:
Manifestações estudantis na ETF-CSF através do periódico O Mícron (1964-1967)
Authors: Borba Rodrigo Cerqueira do Nascimento
Published: September 2019

O artigo apresenta e analisa representações e discursos encontrados em dez números do periódico estudantil O Mícron produzidos entre 1964 e 1967 pela Agremiação Estudantil Técnico-Industrial, entidade representativa dos estudantes da Escola Técnica Federal Celso Suckow da Fonseca, durante a ditadura civil-militar. Amparados por referenciais da análise do discurso (ORLANDI, 2007) e do campo da História da Educação, dentre eles Bastos (2016) e Nóvoa (1997), produzimos uma narrativa sobre o movimento estudantil no Rio de Janeiro cotejando indícios de disputas, contradições e dissensos que ajudaram a constituir as páginas do impresso. Com esse texto, também almejamos contribuir para o fortalecimentodo movimento historiográfico em prol do uso da imprensa estudantil como fonte histórica.
História da educação no Rio de Janeiro: uma reflexão sobre fronteiras
Authors: Alves de Oliveira Claudia Maria Costa
Published: September 2019

A partir de inventário em programas de pós-graduação no Brasil (1972-2001), são desenvolvidas proposições sobre a delimitação da história da educação como área de estudos e sobre o Rio de Janeiro como campo empírico de pesquisas. Em face da consolidação e profusão quantitativa atual da área, apresenta-se, com base na última década, os trânsitos e fronteiras que imprimem novos contornos para a história da educação, em função da emergência de áreas temáticas específicas do campo. Procura-se demonstrar como o diálogo com os campos da educação e da história continuam necessários para o aprofundamento de categorias como “regional”, “nacional”, “município”, de modo a se erguer uma historiografia da educação fluminense não apartada do domínio das ferramentas do conhecimento histórico.
Instituto de Educação Sarah Kubitschek: as origens da “Brasília de Miécimo” (1957)
Authors: Lima Fábio Souza
Published: September 2019

Este artigo visa contar a história do surgimento do Instituto de Educação Sarah Kubitschek (IESK), na zona oeste da cidade do Rio de Janeiro. Com um campus grande o suficiente para sediar, atualmente, a Universidade Estadual da Zona Oeste (UEZO), a unidade tem suas origens no final da década de 1950, sendo fruto de uma luta política com interesses públicos e privados, dentro de um contexto de expansão da rede de ensino da então capital do Brasil.
Do falso luxo à miséria geral: cidades (in)visíveis
Authors: Almeida Cíntia Borges de
Published: September 2019

A proposta do trabalho visa problematizar as representações de cidade moderna e uma busca pelo controle da população que circulava nesse espaço em transformação a partir dos projetos de reforma urbana pensados para a cidade do Rio de Janeiro, nas primeiras décadas do século XX. Pela análise dos discursos (FOUCAULT, 2001), a partir da imprensa carioca e por via das crônicas publicadas pelo literato Lima Barreto, na revista Careta, compreende-se a educação formal como parte de um projeto civilizatório, imbricada a um projeto urbanístico de cidade. Contudo, verifica-se, nas reformas implementadas pelos poderes públicos, a divisão da cidade entre o desenvolvimento do centro urbano e as mazelas do subúrbio e das favelas, evidenciando uma forjada modernidade observada pelo direcionamento de mais investimentos na cidade para se ver do que na cidade para se viver.
Práticas pedagógicas da escola normal de Niterói na Primeira República
Authors: Ecar Ariadne Lopes
Published: September 2019

Neste artigo apresentamos a constituição das práticas pedagógicas da Escola  Normal de Niterói, na Primeira República. O recorte temporal foi delimitado pelas leis que reformaram a formação de professores fluminense, do fim do século XIX até a década de 1910. As Leis e as Mensagens dos Presidentes de Estado (1892-1924) formam um corpus documental imprescindível para a compreensão da cultura escolar e do estabelecimento do conteúdo programático, das disciplinas, e como ocorriam os exames de admissão, bem como os exames finais de Pedagogia, disciplina basilar da formação de professores. Ora criticada, ora alçada a lugar de destaque, consideramos que a Escola Normal de Niterói exerceu papel exemplar formando professores e contribuindo com a expansão da educação fluminense.
Crianças e processos de significação em movimentos de guarda
Authors: De Medeiros Andréa Borges
Published: September 2019

Este texto tem como propósito refletir sobre movimentos de guarda que geraram um arquivo de práticas numa escola pública do interior de Minas Gerais, envolvendo a equipe escolar bem como crianças e adolescentes. Trata-se de um fragmento de uma tese de doutorado, que teve como foco compreender modos de narrar e de lembrar das crianças quando em contato com práticas vivenciadas na escola. Buscando inspiração na poética barrosiana, a condição do objeto como um inutensílio, foi tomada na relação com aqueles preservados nos espaços de musealização, quando da afirmação de Mário Chagas de que cada observador pesquisa, pergunta e procura depreender dos objetos, pistas que podem indicar vínculos de pertencimentos, bem como singulares processos de rememoração.
ANÁLISE DE PERDA DO SOLO POR EROSÃO NA BACIA HIDROGRÁFICA DO RIO COREAÚ (CEARÁ-BRASIL)
Authors: Sousa Francisco Rodrigo Cunha de , Paula Davis Pereira de
Published: September 2019

O conhecimento da intensidade dos processos erosivos contribui para o planejamento ambiental de bacias hidrográficas, especialmente das bacias inseridas no contexto de semiaridez do Nordeste brasileiro, como é o caso da bacia hidrográfica do rio Coreaú, localizada na porção Noroeste do estado do Ceará. Este estudo tem por objetivo estimar as perdas de solos da bacia hidrográfica do rio Coreaú através do emprego da Equação Universal de Perda de Solo (USLE). O fator de erosividade das chuvas foi calibrado a partir de análises estatísticas de séries históricas de precipitações pluviométricas nos postos inseridos no interior da bacia em questão. As demais variáveis da Equação Universal de Perdas de Solos foram obtidas por meio de Sistema de Informação Geográfica (SIG), destinado à análise geoespacial da bacia hidrográfica. Em síntese, os resultados das análises obtidos pela USLE, demonstram que na bacia do rio Coreaú perde-se, em média, 15,80 t.ha-1.ano-1 de solos, sendo que que 993,709 Km2 da bacia do rio Coreaú apresentam perda anual de solo acima de 50 t.ha-1.ano-1, o que equivale a 9,4 % da área da pesquisa. Nessas áreas, os processos erosivos são bem mais intensos e, muitas vezes, ocorrem diretamente sobre a rocha exposta, pois o solo já foi totalmente carreado.
SANTOS BEACH MORPHODYNAMICS UNDER HIGH-ENERGY CONDITIONS
Authors: Stein Luiza Paschoal , Siegle Eduardo
Published: September 2019

A cidade de Santos está localizada no sudeste do Brasil. É uma região de alta densidade demográfica, alta importância turística e inclui o maior porto da América Latina. Tais atividades estão relacionadas ao mar e impactam e são impactadas pelos processos erosivos da praia local. Aqui, avaliamos a morfodinâmica da praia de Santos como resposta às condições de ondas energéticas. Como a Baía de Santos está voltada para o sul, o arco praial está exposto a ondas de tempestade geradas por frentes frias. Portanto, nosso objetivo foi analisar os dados morfológicos da Praia de Santos durante o período das condições energéticas de abril a agosto. A coleta de dados morfológicos foi realizada em intervalos de aproximadamente 20 dias. Os dados de onda para o período estudado foram extraídos do modelo global de geração de ondas, WaveWatch III (NOAA) e usados como condições de contorno para o modelo de propagação de ondas Delft3D-WAVE. Os resultados do estudo mostram a relação direta entre a incidência de ondas com maiores alturas durante um período de dois ou mais dias (associado a frentes frias) com a perda do volume da praia. A dinâmica da praia varia de leste a oeste. Mesmo com ondas mais altas atingindo a parte mais a oeste exposta da praia, seu volume varia menos que a parte leste mais protegida da praia. Áreas com perfis ligeiramente mais inclinados e que normalmente são menos energéticas (porção leste) apresentam maior variabilidade morfológica, sendo, portanto, mais instáveis e sensíveis a altas energias de onda quando comparadas às áreas altamente dissipativas (porção oeste).
DISTRIBUIÇÃO E CONTEXTO GEOLÓGICO-GEOMORFOLÓGICO DA BAUXITA NA REGIÃO DE ESPERA FELIZ, SUL DA SERRA DO CAPARAÓ, MG/ES
Authors: Da Silva Fabricio Sousa , De Oliveira Fabio Soares , Souza Filho Carlos Roberto
Published: September 2019

Este estudo objetivou identificar e caracterizar o contexto geológico-geomorfólogico das ocorrências de bauxita no sul da Serra do Caparaó, entre os estados de Minas Gerais e Espírito Santo, a partir de dados de espectroscopia de reflectância, difração de raios-X e imagens multiespectrais do sensor Aster. A difração de raios-X evidenciou a presença de gibbsita, caulinita, hematita, goethita e quartzo na bauxita. Espécies minerais equivalentes também foram determinadas a partir da interpretação espectro-mineralógica. A reflectância espectral demonstrou a existência de um nível de degradação diferenciado entre as amostras. A degradação sugere a transformação das condições ambientais (sobretudo bioclimáticas).  Foram utilizadas cinco assinaturas espectrais obtidas em laboratório a partir de amostras de bauxita para classificação espectral da imagem ASTER com o classificador Spectral Angler Mapper (SAM).  Os resultados mostram a distribuição da bauxita em todos os compartimentos geológicos da região. Trabalhos de campo, entretanto, indicam a existência de inconsistências e falsos-positivos. A principal inconsistência está relacionada à presença de bauxita associada aos paragnaisses do Grupo Andrelândia, que sugere não ter sido a principal rocha formadora de bauxita. A maior parte das ocorrências está ligada às rochas da Suíte Caparaó e em posições da paisagem que reiteram a existência de uma paleo-superfície bauxitizada, desnivelada topograficamente.
DATAÇÃO POR LUMINESCÊNCIA OPTICAMENTE ESTIMULADA (LOE) NAS CRISTAS DE PRAIA DO DELTA DO RIO PARAÍBA DO SUL (RJ): CONSIDERAÇÕES SOBRE A EVOLUÇÃO GEOMORFOLÓGICA ENTRE O PLEISTOCENO SUPERIOR E O HOLOCENO
Authors: Da Rocha Thais Baptista , De Vasconcelos Sérgio Cadena , Pereira Thiago Gonçalves , Fernandez Guilherme Borges
Published: September 2019

As cristas de praia são feições arenosas construídas pela ação das ondas que marcam posições pretéritas da linha de costa, em função de flutuações no nível do mar e condições de aporte sedimentar, sendo comumente encontradas nas áreas de influência de deltas dominados por ondas. Recentemente elas têm sido datadas pelo método da Luminescência Opticamente Estimulada (LOE), o que tem permitido a reconstrução paleogeográfica de planícies costeiras durante o Quaternário. Além disso, essas cristas também podem ser utilizadas como paleoindicadores de variações do nível do mar. No delta do rio Paraíba do Sul (RJ), os principais modelos de evolução geomorfológica foram construídos a partir de idades obtidas por radiocarbono, cujas cristas de praia nem sempre fornecem materiais para a datação. Nesse sentido, o objetivo do presente trabalho é investigar a geocronologia das cristas de praia do delta do rio Paraíba do Sul, a partir do método da LOE. Foram coletadas 11 amostras no flanco norte do delta, e 10 amostras no flanco sul. Todas as amostras foram analisadas a partir do Protocolo SAR, com 15 alíquotas cada.  Os resultados corroboraram muitas discussões anteriormente debatidas, a partir de idades estabelecidas por radiocarbano. Porém, os novos resultados de idades LOE estabelecidos diretamente a partir das cristas de praia levantaram novas questões acerca da evolução do delta. No flanco norte, a idade N3 (4.130 ± 580 anos) marca o início da progradação da planície, como resposta ao aporte sedimentar do rio Paraíba do Sul e a diminuição do nível relativo do mar após o Máximo Transgressivo do Holoceno. Os dados geomorfológicos e topográficos mostram que essa progradação foi gerada a partir de regressão forçada. As idades N1 (38.650±3.170 anos) e N2 (9.400±1.300 anos) mostram que o Pleistoceno Superior e a transição entre o Pleistoceno/Holoceno precisam ser melhor investigados. No flanco sul, a datação nas cristas próximas aos truncamentos erosivos sugere que os ciclos erosivos ou de interrupção da progradação podem ultrapassar um século. As estimativas das taxas de progradação mostram que as taxas foram mais rápidas no flanco sul do que o flanco norte, apresentando cerca de 5,0 m/ano e 3,0 m/ano, respectivamente. Esse resultado sugere a possibilidade de uma segunda fonte sedimentar, além do rio Paraíba do Sul, responsável pela construção da planície no flanco sul.
Radiation Diagnostic Techniques for Dynamically Controling the Efficiency of Laser-Induced Thermotherapy for Baker’s Cyst
Authors: Chernyad’ev S. A. , Aretinskiy V. B. , Sivkova N. I. , Zhilyakov A. V. , Korobova N. Yu. , Blinov V. S.
Published: September 2019

A popliteal cyst or Baker’s cyst is easily distinguished from other cystic or solid tumors on the magnetic resonance imaging sections. At the current level of medicine development, many options have been developed for medical and surgical treatments for popliteal cysts; however, there are still disputes on their validity and efficiency. In addition, there is no consensus on the etiology and pathogenesis of the disease. MRI is known to show similar intraarticular changes in asymptomatic patients and articular syndrome patients, which could suggest that intraarticular pathological changes played a secondary role in a number of cases of Baker’s cyst formation. Under these conditions, laser-induced thermotherapy is considered by the authors to be justified. Its main goal is to coagulate the wall of the tissue cyst, which subsequently leads to obliteration of its anastomosis and cavity. Ultrasound control is used to visualize and ensure the safety of manipulation. This paper describes a case of MRI for diagnosing a popliteal cyst and monitoring the efficiency of laser-induced thermotherapy.
Comparative Study of the Reactivity of the Tungsten Oxides WO2 and WO3 with Beryllium at Temperatures up to 1273 K
Authors: Köppen Martin
Published: September 2019

Tungsten oxides play a pivotal role in a variety of modern technologies e.g., switchable glasses, wastewater treatment, and modern gas sensors. Metallic tungsten is used as armor material, for e.g., gas turbines as well as future fusion power devices. In the first case, oxides are desired as functional materials, while in the second case, oxides can lead to catastrophic failures, so avoiding the oxidation of tungsten is desired. In both cases, it is crucial to understand the reactivity of tungsten oxides with other chemicals. In this study, the different reactivities of tungsten oxides with the highly-oxophilic beryllium are studied and compared. Tungsten-(IV)-oxide and tungsten-(VI)-oxide layers are prepared on a tungsten substrate. In the next step, a thin film of beryllium is evaporated on the samples. In consecutive steps, the sample is heated in steps of 100 K from r. t. to 1273 K. The chemical composition is investigated after each experimental step by high-resolution X-ray photoelectron spectroscopy (XPS) of all involved core levels as well as the valence band. A model is developed to analyze the chemical reactions after each step. In this study, we find that tungsten trioxide was already reduced by beryllium at r. t. and started to react to form the ternary compounds BeWO3 and BeWO4 at temperatures starting from 673 K. However, tungsten dioxide is resistant to reduction at temperatures of up to 1173 K. In conclusion, we find WO2 to be much more chemically resistant to the reduction agent Be than WO3.
Molecular Basis of Aromatase Deficiency in a 46, XX Patient with Mutation of Arginine 550 to Tryptophan in POR: Expanding the Endocrine Phenotype in PORD
Authors: Parween Shaheena , Fernández  Cancio Mónica , Benito-Sanz Sara , Camats Núria , Velazquez Maria Natalia Rojas , López-Siguero Juan-Pedro , Udhane Sameer S , Kagawa Norio , Flück Christa , Audì Laura , Pandey Amit
Published: September 2019

Context: Mutations in Cytochrome P450 oxidoreductase (POR) cause a form of congenital adrenal hyperplasia (CAH). We are reporting a novel R550W mutation in POR identified in a 46, XX patient with signs of aromatase deficiency. Objective: Analysis of aromatase deficiency from R550W mutation in POR. Design, Setting, and Patient: Both the child and the mother had signs of virilization. Ultrasound revealed the presence of uterus and ovaries. No defects in CYP19A1 were found, but further analysis with a targeted Disorders of Sexual Development NGS panel (DSDSeq.V1, 111 genes) on a NextSeq (Illumina) platform in Madrid and Barcelona, Spain, revealed compound heterozygous mutations c.73_74delCT/p.L25FfsTer93 and c.1648C>T/p.R550W in POR. WT and R550W POR were produced as recombinant proteins and tested with multiple cytochrome P450 enzymes at University Children’s Hospital, Bern, Switzerland. Main Outcome Measure and Results: R550W POR showed 41% of the WT activity in cytochrome c and 7.7% activity for reduction of MTT. Assays of CYP19A1 showed a severe loss of activity and CYP17A1, as well as CYP21A2 activities, were also lost by more than 95%. Loss of CYP2C9, CYP2C19, and CYP3A4 activities was observed for the R550W-POR. Predicted adverse effect on aromatase activity as well as a reduction in binding of NADPH was confirmed. Conclusions: Pathological effects due to POR R550W were identified, expanding the knowledge of molecular pathways associated with aromatase deficiency. Screening of the POR gene may provide a diagnosis in CAH without defects in genes for steroid metabolizing enzymes.
Preprint: Data on Peer Reviewed Papers about Recreational Disturbance of Coastal Avifauna
Authors: Simpson Greg D. , Marasinghe Sumudu , Newsome David , Perera Priyan
Published: September 2019

This data descriptor summarizes the process applied to identify, screen, select and gather data from the content of 142 peer-reviewed papers/sources that report on the sources and impacts of recreational disturbance on coastal avifauna. While populations of resident and migratory coastal avifauna are under threat and diminishing rapidly across the planet, and particularly in association with Asian flyways, many governments are leveraging booming global demand for coastal recreation and tourism in order to deliver economic development to regional communities. The summary data shared via this data description was extracted from papers collected in a systematic literature review that was designed to explore the global literature on the recreational disturbance of coastal avifauna in order to elucidate the state of the global knowledge regarding this issue and to identify management strategies that could be applied at tropical Asian destinations to minimize the impacts of recreational disturbance and thus enhance the ecological sustainability of coastal recreation and tourism across the region. The data shared via the Excel worksheet associated with this data descriptor was extracted from peer-reviewed articles published in English between 1 January 2000 and the 31 December 2018 with the full text of the article available online. These articles were found by searching several online indexing several databases including Scopus, Web of Science, ProQuest and Google Scholar.
Lista anotada de Bombicóideos (Lepidoptera:Bombycoidea) del Parque Nacional Natural Utría, Colombia
Authors: Prada Lara Liliana , Correa-Carmona Yenny , Clavijo Giraldo Alejandra , Vargas Sergio Andrés , Parrales Dumar Ariel
Published: September 2019

Se presenta una lista anotada de especies de las familias Bombycidae, Saturniidae y Sphingidae recolectadas en el Parque Nacional Natural Utría, Chocó, Colombia. El muestreo se realizó en cuatro hábitats del parque durante 31 días, utilizando una trampa de luz con un bombillo de vapor de mercurio. Se registraron 35 especies: 19 Saturniidae, 15 Sphingidae y 1 Bombycidae. Por primera vez para el departamento del Chocó se registran 18 especies. Se resaltan los registros de las especies Syssphinx chocoensis, endémica del Chocó colombiano, Manduca dalica dalica depositada por primera vez en una colección colombiana y el quinto instar de Isognathus scyron. El número de individuos recolectados concuerda con la hipótesis de la fobia lunar. El presente trabajo es la primera aproximación a la diversidad de estas familias para el Parque Nacional Natural Utría.
Madurez de procesos en pequeñas empresas manufactureras de México
Authors: Carballo-Mendívil Blanca , Arellano-González Alejandro , Ríos-Vázquez Nidia Josefina
Published: September 2019

Rev.esc.adm.neg

Se presentan los resultados de un proyecto cuyo objetivo fue realizar un diagnóstico de procesos con enfoque de madurez, de pequeñas empresas manufactureras en México, con la intención de obtener datos de su situación actual como insumo para el futuro planteamiento de propuestas de mejora. 

En este artículo se muestra una síntesis de la literatura relacionada al tema de madurez organizacional, donde se detecta que son pocos los modelos aplicables a este tipo empresas, y menores aún aquellos con enfoque adecuado para el diagnóstico de procesos, por lo que se utilizó el modelo de la Arquitectura del Desempeño Organizacional en una Cadena de Suministro (ADOCS), el cual establece doce procesos organizacionales agrupados en cuatro categorías, y se diseñan instrumentos en formato de rúbrica para identificar el nivel de cumplimiento de cada proceso con respecto a ideales establecidos a partir de modelos teóricos, calculando el nivel de madurez alcanzado de los cuatro propuestos. 

Los hallazgos muestran que la mayoría de estas empresas operan con un nivel de madurez artesanal, lo cual indica que se tiene conocimiento general sobre el enfoque de mejora continua, pero no se han formalizado ni sistematizado los procesos, aunque si se implementan esporádicamente mejoras con un enfoque correctivo.
NDRG2 combined with EGFR improved its prognostic value for lung adenocarcinoma
Authors: Yang Bo , Li Xiao-Ping , Zhou Hong-Gang , Jiang Tao , Xiao Ting , Wei Yu-Li , Zhang Liang , Wang Wen-Chen , Zhang Wei-Dong
Published: September 2019

Background N-Myc downstream-regulated gene2 (NDRG2) plays an important role in lung adenocarcinoma (LUAD). Epidermal growth factor receptor (EGFR) mutation has significantly improved prognosis in patients with adenocarcinoma. We aimed to elucidate the clinical value of NDRG2/EGFR as a prediction of prognosis in patients with lung adenocarcinoma.Materials and Methods Immunohistochemistry and western blot analysis were conducted to detect the expression of NDRG2 protein. Association between NDRG2/EGFR expression and clinicopathological parameters of the patients were examined. Serum Carcinoembryonic antigen (CEA) level was examined prior to treatment in patients with LUAD. Patients’ survival rate was assessed by Kaplan–Meier. Candidates for independent prognostic biomarkers were analyzed using a COX proportional hazard model.Results NDRG2 levels were significantly decreased in patients with lung adenocarcinoma. NDRG2 levels were positively correlated with CEA and EGFR. Advanced stages were significantly associated with low expression of NDRG2. Patients with NDRG2-high combined with EGFR-positive expression had the best prognosis during the 5-year follow-up period. Meanwhile, COX regression analysis showed that the conjoined expressions of NDRG2-low/EGFR-positive, NDRG2-high/EGFR-positive and vascular invasion were independent prognostic indicators for lung adenocarcinoma.Conclusion NDRG2 is of more prognosis value as the biomarker for lung adenocarcinoma when analyzed combined with the EGFR expression.
MDR1 polymorphisms are not related to Xeliri and Xelox chemoresistance in colorectal cancer
Authors: Al-Ghafari Ayat B. , Alqahtani Areej M. , Alturki Suzan N. , Doghaither Huda Abdulaziz Al , Tashkandi Hanaa M. , Abusanad Atlal M. , Alkhayyat Shadi S. , Omar Ulfat M. , Zeeneldin Ahmed A.
Published: September 2019

Background Multidrug resistance member 1 (MDR1) is located on chromosome 7 and encodes P-glycoprotein (Pgp), which is universally accepted as a drug resistance biomarker. MDR1 polymorphisms may change either the protein expression or function, suggesting its possible association with cancers, including colorectal cancer (CRC). Thus, this study aimed to determine the effects of MDR1 polymorphisms on the drug response of Saudi CRC patients.Methods DNA samples were obtained from 62 CRC patients and 100 healthy controls. The genotypes and allele frequencies of the MDR1 polymorphisms G2677T and T1236C were determined by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP).Results No significant difference was observed in the genotype distribution and allele frequency of T1236C between the CRC the patients and the controls. However, G2677T was found to play a highly significant protective role against the progression of CRC. Moreover, the results showed that none of the genotypes in SNPs T1236C and G2677T affected chemoresistance to Xeliri and Xelox.Conclusions T1236C in the MDR1 gene is not related to CRC risk, and G2677T protects against the development of CRC. Both MDR1 polymorphisms are not associated with the risk of chemoresistance.
Maintenance phototherapy for the treatment of early stage mycosis fungoides
Authors: Gara Soumaya , Litaiem Noureddine , Bacha Takwa , OUEDRAOGO Djamila Sandra , Jmour Yosra , Zeglaoui Faten
Published: September 2019

Background : Phototherapy has been a mainstay of treatment of early stages (Ia-IIa) of mycosis fungoides (MF). Despite this, there is no internationally standardized phototherapy regimen schedule for MF. Efficacy of maintenance therapy is poorly evaluated especially in patients with dark phototype (IV-VI). Methods : Thirty patients with early stage MF treated with PUVA therapy and narrowband UVB therapy from January 2004 to January 2016 at a single institution were retrospectively reviewed. Recurrence rate and recurrence-free survival were assessed in patients who received maintenance phase and in those who underwent follow-up. Results : Seventeen patients had patch stage disease while 16 patients had plaque stage disease. Most of the patients (22, 73%) had dark phototype. Nineteen patients received NB-UVB therapy, while 11 patients received PUVA. Mean follow-up period was 36,1 + 13 months. There was no significant association between the recurrence rate and recurrence free survival in patients who received maintenance phase and those who underwent follow-up. Conclusions: Phototherapy is a safe and effective treatment option for patients with early stage MF. Evidence supporting the use of maintenance phase for the treatment of early stages MF is lacking.
Tibetan wild asses (Equus Kiang) were superior to domestic donkeys (Equus Asinus) in terms of the composition and function of gut microbial community
Authors: Liu Hongjin , Zhao Xinquan , Xu Shixiao , Zhao Liang , Hu Linyong , Xu Tianwei , Zhao Na , Zhang Xiaoling , Li Qi , Chen Dongdong , He Fuquan , Chen Xin
Published: September 2019

Background: Tibetan wild asses are the only wild species of perissodactyls on the Qinghai-Tibetan Plateau, and appears on the International Union for Conversation of Nature (IUCN) 2012 Red List of threatened species. The gut microbiota has a great effect on the health and nutrition of the host, however, scant research is available on the characteristics of their intestinal microbiota. Therefor, understanding the gut microbita composition and function of TWAs can provide a theoretical for the situ conservation of wild animals in the future. Results: To characterize its composition and function, we analyzed the intestinal microbiota of wild asses and domestic donkeys by high-throughput sequencing of the 16s rDNA regions. No significant difference in alpha diversity was detected between these two groups. Beta diversity showed that the bacterial community structure of wild asses was acutely different from domestic donkeys. At the phylum level, the two dominant phyla of Bacteroidetes and Firmcutes in wild asses were significantly higher than that in domestic donkeys. At the genus level, Ruminococcaceae_NK4A214 , Phascolarctobacterium , Coprostanoligenes_group , Lachnospiraceae_XPB1014_group and Akkermansia in wild asses were significantly higher than domestic donkeys. Moreover, statistical comparisons showed that 40 different metabolic pathways exhibited significant differences . Among them, 29 pathways had richer concentrations in wild asses than domestic donkeys, mainly amino acid metabolism, carbohydrate metabolism, and energy metabolism. Of note, network analysis showed that wild asses harbored a relatively more complex bacterial network than domestic donkeys, possibly reflecting the specific niche adaption of gut bacterial communities through species interactions. Conclusions: Wild asses were superior to that of domestic in gut microbial community composition and function. For wild animal conservation, wild asses are more suitable to survive in wild than to be domesticated or captive. Key words: Tibetan wild asses, domestic donkeys, 16S ribosomal RNA gene, gut microbiota
MMP-9 contributes to glomerulosclerosis by causing profibrotic changes in podocytes and glomerular endothelial cells
Authors: Qiao Xi , Guo Jianhong , Loron M , Liu Lixin , Rao Padmashree , Zhao Ye , Cao Qi , Wang Yiping , Wang Yuan Min , Lee Vincent VW , Alexander Stephen I , Harris David CH , Zheng Guoping
Published: September 2019

Background Glomerulosclerosis is characterized by progressive (myo)fibroblast accumulation and collagen deposition involving profibrotic changes of podocytes and endothelial cells. A profibrotic role of MMP-9 in interstitial fibrosis has been reported. Whether MMP-9 plays a role in glomerulosclerosis is not clear yet. Methods A mouse glomerulosclerosis model [adriamycin nephropathy (AN)] was produced in MMP-9-/- and wild-type control BALB/c mice. All animals were sacrificed at 4 weeks after injection. Albuminuria (albumin to creatinine ratio) and calculated GFR were measured. Gomori Trichrome (GT) and Sirius Red (SR) staining were used for assessment of glomerular fibrosis. Profibrotic changes of podocytes or glomerular endothelial cells were examined by confocal microscopy using immunofluorescence staining (IF) of desmin or α-SMA with P-cadherin or VE-cadherin. Results Albuminuria was reduced while GFR was increased in MMP-9-/- AN mice compared with those of wild-type mice. Confocal microscopy showed a significant decrease in podocytes double-stained with P-cadherin and desmin and decrease in glomerular endothelial cell co-staining with VE-cadherin and α-SMA, demonstrating that MMP9-/- AN mice were protected from profibrotic changes in podocytes and glomerular endothelial cells. Glomerulosclerosis was significantly reduced in MMP-9-/- AN mice compared to that of WT, as demonstrated by GT and SR staining. Conclusions MMP-9 contributes to profibrotic changes in podocytes and glomerular endothelial cells and thereby glomerulosclerosis.
Gingivitis in Mice and the Role of Angiogenesis
Authors: Saghiri Mohammad Ali , Moghadam Mona Momeni , Fakharzadeh Amir , Morgano Steven M , Asatourian Armen , Sheibani Nader
Published: September 2019

Background Gingivitis is the first step in an abnormal oral condition, which degrades connective tissue and eventually converts to periodontal diseases leading to alveolar bone and tooth loss. Thrombospondin-1 (TSP1) and Bcl-2 are key regulators of angiogenesis. The transition from gingivitis into periodontitis has four stages and disease progression depends very heavily on changes to the surrounding vasculature structures. We hypothesized that vascular dysfunction plays an important role in the progression of gingivitis. Here we have measured Gingival Crevicular Fluid (GCF) levels in TSP1 and Bcl-2-deficient mice, in which vascular structures are affected, while also looking at the roles that age and gender play in this process. Methods Thirty mice (15 males and 15 females) were divided into three groups of ten (n=10): group A (WT), group B (TSP1 -/-), and group C (Bcl-2 -/-) were subjected to collection of Gingival Crevicular Fluid (GCF). Saliva was collected from different groups of mice after subcutaneous injection of pilocarpine. For the WT group, GCF was monitored for 3, 4, 5 and 6 weeks and the contribution of age was also considered. RESULTS: Samples from Bcl-2 -/- mice showed significantly lower levels of GCF and salivary secretions, while TSP1-/- mice were larger and secreted more saliva. Moreover, the TSP1-/- mice GCF level was significantly higher than that of both the WT and Bcl-2 -/- mice. CONCLUSIONS: The absence of Bcl-2 and TSP1 significantly affects the amount of GCF flow in mice. This current study confirms the important role that alteration of pro- and anti-angiogenic factors can play in the progression of gingivitis and in the amount of salivary secretions. Thus, this type of modulation of angiogenic proteins provides a great opportunity and a novel platform for developing enhanced oral care products of the future. TSP1 showed significantly more saliva secretion, and a larger volume of periodontal pocket. This means that higher level saliva secretion can affect periodontal pocket volume and eventually oral hygiene.
Yarning about oral health: perceptions of urban Australian Aboriginal and Torres Strait Islander Women
Authors: Butten Kaley , Johnson Newell W. , Hall Kerry K. , Toombs Maree , King Neil , O’Grady Kerry-Ann F.
Published: September 2019

Background: Many factors influence how a person experiences oral health and how such experiences may facilitate supportive oral health behaviours. Women in particular face different challenges due to their environment, responsibilities and physiological differences to men. Within Australia, Aboriginal and Torres Strait Islander women are reported to have poorer oral health and are faced with additional barriers to supporting their oral health compared with non-Indigenous women. The objective of this paper is to report the experiences and perceptions of oral health from the perspective of urban, Aboriginal and Torres Strait Islander women. Methods: The present data derive from a descriptive study that used yarning circles and face-to-face interviews with women who were mothers/carers of urban, Aboriginal and/or Torres Strait Islander children. This was a qualitative study to investigate the impact of child oral health on families. Participants used the opportunity to share their own personal experiences of oral health as women, thus providing data for the present analyses. Information collected was transcribed and analysed thematically Results: 20 women shared their personal narratives on the topic of oral health which were reflective of different time points in their life: growing up, as an adult and as a mother/carer. Although women are trying to support their oral health across their life-course, they face a number of barriers, including a lack of information and the costs of accessing dental care. The teenage years and pregnancy were reported as important time periods for oral health support. Conclusions: To improve the oral health of Indigenous Australian women, policymakers must consider the barriers reported by women and critically review current oral health information and services. Current oral health services are financially out of reach for Indigenous Australian women and there is not sufficient or appropriate, oral information across the life-course.
Have our strictures changed? Analysis of Current Characteristics and Management of Urethral Stricture Disease in Zaria, Nigeria
Authors: Oyelowo Nasir , Ahmed Muhammed , Bello Ahmad , Lawal Ahmad Tijani , Maitama Husseni Yusuf , Muhammad Muhammad Salihu , Abdulsalam Khalifa , Bilyaminu lawal Bola , Olagunju Jemila
Published: September 2019

Introduction:
Urethral stricture is a common cause of lower urinary tract symptoms in the middle aged and elderly men. Its presentation and management is closely linked with its etiology and this varies across geographical regions of the world as well as over time.
We hereby review the etiology, characteristics and presentation of men with urethral strictures in a tertiary hospital in northern Nigeria over a year and compare it with previous studies in the region.
Patients and Methods
The study was a prospective study from January-December 2016, all patients with urethral strictures and who consented to the study were enrolled into the study. Data was collected using a structured study profoma and analyzed using SPSS version 23.
Results
The mean age was 44.1 years with a range of 13-71 years. The bulbar urethra was the site of most strictures with a frequency of 65%. The etiology was infection in majority of the patients with a frequency of 53.3%. Post traumatic strictures occurred in 33.3% while iatrogenic and catheter –Induced strictures were seen in 7.1% and 6% respectively. 88% had no previous intervention for the stricture prior to presentation.The complications from urethral strictures observed in the patients were acute urinary retention in 83.4% urethrocutaneous fistulae in 2.4% and urosepsis in 1.2% of the patients. 11% presented with no complication.68% of these patients were managed by excision and end to end anastomosis, 15 % had a penile pedicled flap 12% , a buccal mucosa graft urethroplasty and 5% with staged urethroplasty
The trends in etiology of urethral stricture disease in the region reported is: Ahmed etal in zaria (1990) Infection accounted for 66.50% , post traumatic stricture 31.50%. Ntia et al Sokoto (2006)found infection as aetiology in 44.70% and post-traumatic strictures in 47.40%. Ofoha et al in Jos however found Infection in 53.30% and post traumatic 40.30%
Conclusion
Though there is a gradual rise in post-traumatic and iatrogenic strictures in our environment, Post inflammatory strictures still predominates. It is however infrequently accompanied by fistulae as seen decades ago. These strictures are mostly long segments single bulbar strictures
Comparison of the oncological and functional outcomes of brachytherapy and radical prostatectomy for localized prostate cancer
Authors: Wang Fei , Ding Xue fei , Luan Yang , Xu Yao-zong , Guo Cheng-hao , Zhu Liang-yong
Published: September 2019

Objective:To compare the oncological and functional outcomes of brachytherapy(BT) and radical prostatectomy(RP) in patients with localized prostate cancer(PCa).Methods:We retrospectively analyzed data from 415 patients with localized PCa who were treated with RP (n= 280) or BT (n=135) at Northern Jiangsu People's Hospital between November 2012 and April 2019. Biochemical relapse-free survival(bRFS) and cancer-specific survival (CSS) were compared. Multivariate Cox regression analysis was used to evaluate bRFS. Health-related quality of life(HRQoL) was measured using the Expanded Prostate Cancer Index Composite(EPIC) questionnaire.Results:The BT group was older, had a higher initial PSA, and had a higher proportion of high-risk patients. The median follow-up time was 38.6 months. The 3-year bRFS was 77.3% in the RP group versus 84.0% in the BT group(P=0.246). For the RP group, the 3-year bRFS for patients presenting with low-, intermediate-, and high-risk disease was 90.3%, 79.6% and 71.3%, respectively, compared with 90.9%, 93.8% and 80.7% in the BT group(P=0.948,0.213,0.263, respectively). The 3-year CSS was 96.1% in the RP group versus 94.5% in the BT group(P=0.948). For the RP group, the 3-year CSS for patients presenting with low-, intermediate-, and high-risk disease was 100%, 100% and 92.8%, respectively, compared with 100%, 100% and 92.4%, for the BT group(P=0.620). Based on multivariate Cox regression analysis, clinical T stage ≥ T2b was the main independent prognostic factor for bRFS. Regarding the quality of life, compared with the baseline, both treatments produced a significant decrease in different aspects of HRQoL at 3, 6 and 12 months after treatment. Patients in the BT group had lower HRQoL with regard to urinary irritation/obstruction and bowel function or bother, while patients in the RP group had lower HRQoL concerning urinary incontinence and sexual function or bother. There was no significant difference in HRQOL aspects between the two groups after follow-up for 2 years compared with the baseline.Conclusion:BT provides equivalent oncological control outcomes for patients with localized PCa compared with RP. Clinical T stage ≥ T2b was the independent prognostic factor for bRFS. BT had better HRQoL compared with RP, except for urinary irritation/obstruction and bowel function or bother, but returned to baseline after 2 years.
Clinical effect analysis and radiographic outcomes of Isobar TTL system for two-segmental lumbar degenerative disease: a retrospective study
Authors: Ji Zhisheng , Ji Zhi-Sheng , Yang Hua , Yang Yu-Hao , Li Shao-Jin , Luo Jian-Xian , Zhang Guo-Wei , Lin Hong-Sheng
Published: September 2019

Background: Non-fusion fixation is an effective way to treat lumbar degeneration. The present study evaluated the clinical effect analysis and radiographic outcomes of Isobar TTL system for two-segmental lumbar degenerative disease.
Method: Forty-one patients with two-segmental lumbar degenerative disease who underwent surgical treatment by Isobar TTL dynamic stabilization system (n=20) and rigid system (n=21) from January 2013 to June 2017. The mean follow-up period was 23.6 (range 15–37) months. Clinical outcomes were evaluated by oswestry dysfunction index (ODI), visual analogue score (VAS) and modified Macnab. Radiographic evaluations included the height of intervertebral space and range of motion (ROM) of the operative segments and proximal adjacent segment. The intervertebral disc signal change was classified by the modified Pfirrmann grade and University of California at Los Angeles (UCLA) system.
Results: The clinical outcomes including the ODI and VAS were significantly improved in two groups after operation, but the difference between two groups was not significant. In addition, the clinical efficacy of modified Macnab in two groups was similar too. Radiologic outcomes include height of intervertebral space, lumbar mobility and intervertebral disc signal. The height of intervertebral space of upper adjacent segments of L2/3 in the rigid group were significantly lower than those in the Isobar TTL group at the last follow-up. Furthermore, the number of fixed segment ROM of L3/4 in Isobar TTL group was significantly lower than pre-operation, suggesting that fixed segment ROMs in Isobar TTL group were limited. And, the ROM of upper adjacent segments of L2/3 in the last follow-up of rigid group increased significantly, while the ROM of L2/3 in Isobar TTL group haven’t changed after operation. At last, the incidence of adjacent segment degeneration was significantly greater in the rigid group than the Isobar TTL group according to modified Pfirrmann grading system and the UCLA system.
Conclusion: Isobar TTL system could get a good clinical effect for treatment of two-segmental lumbar degenerative disease. Compared with rigid fixation, Isobar TTL system can get better radiographic outcomes and maintain the mobility of the stabilized segments with less influence on the proximal adjacent segment.
Intra-aortic Balloon Pump Therapy for Anterior ST-elevation Myocardial Infarction with Cardiogenic Shock: An Observational Cohort Study
Authors: Zhou Kuo , Lyu Shuzheng , Dai Jing , Tian Jinfan , Cui Kongyong , Yan Yunfeng , Chen Lingxiao , Qin Zheng , Zhou Yutian
Published: September 2019

Background As a mechanical circulatory assistance, intra-aortic balloon pump (IABP) has been widely used for cardiogenic shock (CS), although recent clinical trials questioned its impact on acute myocardial infarction patients, nothing is hitherto known on the contribution of IABP to CS patients after anterior wall infarction. The aim of this study was to investigate the efficacy and safety of IABP therapy in patients presenting with anterior ST-elevation myocardial infarction (STEMI) complicated by CS.Methods We conducted a retrospective study of 215 consecutive patients presenting with CS after STEMI in the anterior wall between January 2006 and August 2017, including 125 patients in the IABP group and 90 patients in the control group.Results At 30 days, 60 (48.0%) patients in the IABP group and 58 (64.4%) patients in the control group had died (P=0.017). The Kaplan-Meier survival curves showed the cumulative survival rate in the IABP group was consistently higher than control group (P=0.009 by Log-Rank test). Nevertheless, IABP increased the occurrence of thrombocytopenia (21.6% vs. 2.2%, P<0.001) and lower limb complications (20.0% vs. 2.2%, P<0.001) at the same time. Subgroup analyses by Cox regression showed a better trend of prognoses in patients aged less than 60 years old (HR=0.49, 95% CI=0.26-0.91, P=0.025), male (HR=0.53, 95% CI=0.34-0.83, P=0.005), no history of hypertension (HR=0.47, 95% CI=0.26-0.87, P=0.017) and systolic blood pressure less than 80 mm Hg (HR=0.40, 95% CI=0.22-0.73, P=0.009). At 12-month follow-up, all-cause mortality in the IABP group was obviously lower than the control group (52.5% vs. 74.1%, P=0.002), there were no significant differences in other adverse cardiovascular events (P=1.000).Conclusions The combination of IABP use is associated with reduced 30-day and 12-month mortality in patients with anterior STEMI complicated by CS, though thrombocytopenia and lower limb complications are frequently observed.
Combined therapy of somatostatin analogues with pegvisomant for the treatment of acromegaly: a meta-analysis of prospective studies
Authors: Ma Lingyun , Luo Daohuang , Yang Ting , Wu Songtao , Li Min , Chen Chaoyang , Zhou Shuang , Ma Lingyue , Wu Ye , Zhou Ying , Cui Yimin
Published: September 2019

Background: Acromegaly is a rare, chronic and severe disease . Drug therapy including somatostatin analogues , dopamine receptor agonists and growth hormone receptor antagonists are commonly used to treat patients who do not responde to surgery. T he use of combination therapy with PEG and SAs has become more common over the last decade . We performed this study t o accurately evaluate the effect of combination therapy of somatostatin analogues (SAs) with pegvisomant (PEG) on acromegalic patients. Methods: PubMed, EMBASE, The Cochrane Library, and ClinicalTrials.gov were searched for relevant studies. Prospective clinical trials treating acromegaly with the co-administration of SAs and PEG were included. We performed a meta-analysis by using Stata 12.1 . Sensitivity analysis was conducted to explore heterogeneity. Results: Eight studies were included in this meta-analysis. The overall rate of serum insulin-like growth factor 1 (IGF-1) normalization was 75% (95% CI: 50%–93%; I 2 =93.60%). The combination therapy did not significantly change patients’ fasting plasma glucose (ES: 0.011 mmol*L -1 ; 95% CI: − 0.374 to 0.397 mmol*L -1 ; P=0.954) or glycosylated haemoglobin (ES: -0.106%; 95% CI: − 0.302% to 0.089%; P=0.285) while decreasing the fasting plasma insulin (ES: −21.487 pmol*L-1; 95% CI: −35.713 to -7.260 pmol*L-1; P=0.003). Elevation of liver enzyme levels was found in 14% (95% CI: 10% to 19%) of the patients. Conclusions: Combined therapy of SAs and PEG effectively normalized IGF-1 levels in most of the patients whose IGF-1 level was greater than the upper limit of normal after high dose SAs monotherapy. The combination therapy significantly decreased patients’ fasting plasma insulin. However, improved fasting plasma glucose or glycosylated haemoglobin was not found during the combination therapy. Moreover, elevated liver enzyme levels were observed in a small number of patients, which suggests a need for liver function monitoring. Trial registration We have our protocol registered in PROSPERO. (Registration number: CRD42019115549)