bluuebunny/crossref_metadata_2025 huggingface dataset:
Reactogenicity and safety of AS03B-adjuvanted H5N1 influenza vaccine in children: an open-label, one-way, crossover trial
Authors: Izurieta Patricia , Kosalaraksa Pope , Frenette Louise , Dramé Mamadou , Innis Bruce L. , Vaughn David W , Schuind Anne
Published: March 2018

Background

Human cases of highly pathogenic avian-origin influenza A/H5N1 infection continue to be reported to the World Health Organization, and recent outbreaks of human cases of other zoonotic influenza strains highlight the continued need for strategies to mitigate influenza pandemic potential.

Methods

A Phase II–III randomized, placebo-controlled, observer-blind trial was conducted to assess the immunogenicity, reactogenicity, and safety of two 1.9 μg hemagglutinin doses of AS03B-adjuvanted H5N1 (AS03B-H5N1; A/Indonesia) vaccine in children (6 months to <18 years old) of Thailand, the United States, and Canada (Year 1, published elsewhere). After database lock in Year 1, the trial was unblinded, and children who had been randomized to receive placebo and continued to fulfill the eligibility criteria were invited to participate in an open-label, one-way, crossover safety extension phase, in which they received AS03B-H5N1 vaccine. Here we report the safety analysis in Year 2.

Results

A total of 155 children were vaccinated in Year 2. The most frequent solicited adverse event (AE) during 7 days post vaccination was injection site pain. Irritability or fussiness was reported in about one-third of younger children (aged <6 years) during 7 days post vaccination and was the most common solicited general AE in this age group. Postvaccination temperature (≥38°C) was reported in 4 (5.1%) children. The most common solicited general AEs in older children (aged ≥6 years) were muscle aches, headache, and fatigue. The AS03B-H5N1 vaccine had a clinically acceptable safety profile up to 385 days post vaccination.

Conclusions

Safety in the crossover phase was acceptable and consistent with that observed in vaccine recipients in the randomized, blinded phase of the study.

Clinical trial registration

ClinicalTrials.gov: NCT01310413.
Exploring the association between glucose-6-phosphate dehydrogenase deficiency and color blindness in Southeast Asia
Authors: Soontarawirat Ingfar , Imwong Mallika , Woodrow Charles J. , Cheepsunthorn Chalisa Louicharoen , Day Nicholas P.J. , Paul Richard , Singhasivanon Pratap
Published: March 2018

Background

Glucose-6-phosphate dehydrogenase (G6PD) deficiency poses problems for the treatment of Plasmodium vivax malaria, as the 8-aminoquinolines, used to eliminate liver hypnozoites, cause hemolysis in G6PD-deficient individuals.G6PD deficiency is an X-linked disorder that can be linked to other conditions determined by genes located nearby on the Xq28 band of the X chromosome, including red–green color blindness. A Karen population has undergone recent positive selection for G6PD deficiency with extended long-range haplotypes around G6PD.

Objectives

To determine the association between G6PD deficiency and color blindness in a Karen population that lives in an area endemic for P. vivax and that is already known to display long-range haplotypes around G6PD because of the recent positive selection of the Mahidol G6PD deficiency allele.

Method

We examined the phenotypic association between G6PD deficiency and color blindness.

Results

Of 186 male participants successfully assessed for color blindness using the Ishihara 38 plates test, 10 (5.4%) were red–green color blind, while 1 individual was totally color blind. There was a nonsignificant trend toward negative association (repulsion) between G6PD deficiency and red–green color blindness; 34/35 individuals with the Mahidol variant of G6PD deficiency had normal vision, while 9 of the 10 red–green color blind individuals were G6PD normal. A single individual had both conditions.

Conclusions

Despite the long-range haplotype associated with G6PD deficiency in this population, color blindness is not informative in terms of predicting G6PD deficiency in this population. The most likely explanation is that there are multiple genetic causes of red–green color blindness.
Screening antibiotics using an Hoechst 33342 dye-accumulation assay to detect efflux activity in Acinetobacter baumannii clinical isolates
Authors: Choi In-Sun , Kim Choon-Mee , Jang Sook-Jin
Published: March 2018

Background

Understanding the contribution of efflux pumps to the resistance of antibiotics is useful when considering strategies for antimicrobial therapy.

Objectives

To assess the role of efflux activity on the resistance of antibiotics commonly used in hospitals.

Methods

We analyzed the efflux activity of 120 clinical isolates of Acinetobacter baumannii using an Hoechst 33342 (H33342) dye-accumulation assay. We compared the indicators for efflux activity of susceptible and non-susceptible groups of each of 16 tested antibiotics. To determine the role of efflux activity on resistance to an antibiotic, we used 3 criteria based on the results of the H33342-accumulation assay.

Results

The evaluation suggests that efflux activity contributed to resistance to the following 11 antibiotics: cefepime, cefotaxime, ceftazidime, ciprofloxacin, gentamicin, imipenem, meropenem, piperacillin, piperacillin/tazobactam, ticarcillin/ clavulanic acid, and tigecycline. However, ampicillin/sulbactam, minocycline, and trimethoprim/sulfamethoxazole did not meet the criteria, suggesting resistance may not be mediated by efflux activity. A significant difference in efflux activity was observed between bacteria belonging to the multidrug-resistant Acinetobacter baumannii (MDRAB) group and those belonging to the non-MDRAB group.

Conclusions

Efflux activity may contribute to multidrug resistance and particularly resistance to numerous antibiotics used in hospitals. These antibiotics would be good candidates for combination therapeutic regimens consisting of an antibiotic and an efflux pump inhibitor as an adjuvant to combat drug efflux.
The use of Monte Carlo simulation to predict vancomycin dosage for methicillin-resistant Staphylococcus aureus in Thai patients of various ages and with varying degrees of renal function
Authors: Pitaksontayothin Krairerk , Santimaleeworagun Wichai , Pongchaidecha Manat , Houngsaitong Jantana , Srisena Panuwit
Published: March 2018

Background

To our knowledge, no study reported so far has investigated appropriate vancomycin dosing, which is important for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection in Thai patients of various ages and with varying degrees of renal function.

Objectives

To predict vancomycin dosing for MRSA in Thai patients of various ages and with varying degrees of renal functions.

Methods

Monte Carlo simulation and minimal inhibitory concentration (MIC) distribution of MRSA from a hospital in Thailand were used to predict the area under the curve in 24 h/MIC >400 and trough concentration (C
trough) <20 mg/L of 9 vancomycin dosage regimens for Thai patients stratified by age and renal function.

Results

Vancomycin dosing at least 2.5 g per day can attain cumulative fraction of response (CFR) of ≥90% in every age group. Vancomycin dosage achieving CFR of ≥90% for simulated patients with creatinine clearance (CLcr) was calculated using the Cockcroft–Gault equation. Appropriate vancomycin doses for Thai patients infected with MRSA with CLcr of <40, 40–60, >60–80, and >80 mL/min were 1.5 g every 24 h, 1.25 g every 12 h, 1 g every 8 h, and 1.75 g every 12 h, respectively. However, more than a half of patients simulated using these regimens have a vancomycin C
trough of >20 mg/L.

Conclusions

Although vancomycin doses attaining a CFR of ≥90% can treat MRSA infection effectively, the regimens may cause kidney injury. The regimens have a probability of target attainment of 100%, and most patients can attain C
trough of <20 mg/L.
Leibniz on Innate Ideas and Kant on the Origin of the Categories
Authors: Vanzo Alberto
Published: March 2018

In his essay against Eberhard, Kant denies that there are innate concepts. Several scholars take Kant’s statement at face value. They claim that Kant did not endorse concept innatism, that the categories are not innate concepts and that Kant’s views on innateness are significantly different from Leibniz’s. This paper takes issue with those claims. It argues that Kant’s views on the origin of intellectual concepts are remarkably similar to Leibniz’s. Given two widespread notions of innateness, the dispositional notion and the input/output notion, intellectual concepts are innate for Kant no less than for Leibniz.
Global existence of a radiative Euler system coupled to an electromagnetic field
Authors: Blanc Xavier , Ducomet Bernard , Nečasová Šárka
Published: March 2018

We study the Cauchy problem for a system of equations corresponding to a singular limit of radiative hydrodynamics, namely, the 3D radiative compressible Euler system coupled to an electromagnetic field. Assuming smallness hypotheses for the data, we prove that the problem admits a unique global smooth solution and study its asymptotics.
ALD anti-reflection coatings at 1ω, 2ω, 3ω, and 4ω for high-power ns-laser application
Authors: Liu Hao , Jensen Lars , Ma Ping , Ristau Detlev
Published: March 2018

Atomic layer deposition (ALD) facilitates the deposition of coatings with precise thickness, high surface conformity, structural uniformity, and nodular-free structure, which are properties desired in high-power laser coatings. ALD was studied to produce uniform and stable Al2O3 and HfO2 single layers and was employed to produce anti-reflection coatings for the harmonics (1ω, 2ω, 3ω, and 4ω) of the Nd:YAG laser. In order to qualify the ALD films for high-power laser applications, the band gap energy, absorption, and element content of single layers were characterized. The damage tests of anti-reflection coatings were carried out with a laser system operated at 1ω, 2ω, 3ω, and 4ω, respectively. The damage mechanism was discussed by analyzing the damage morphology and electric field intensity difference. ALD coatings exhibit stable growth rates, low absorption, and rather high laser-induced damage threshold (LIDT). The LIDT is limited by HfO2 as the employed high-index material. These properties indicate the high versatility of ALD films for applications in high-power coatings.
Spectral analysis of the He-enriched sdO-star HD 127493
Authors: Dorsch Matti , Latour Marilyn , Heber Ulrich
Published: March 2018

The bright sdO star HD127493 is known to be of mixed H/He composition and excellent archival spectra covering both optical and ultraviolet ranges are available. UV spectra play a key role as they give access to many chemical species that do not show spectral lines in the optical, such as iron and nickel. This encouraged the quantitative spectral analysis of this prototypical mixed H/He composition sdO star. We determined atmospheric parameters for HD127493 in addition to the abundance of C, N, O, Si, S, Fe, and Ni in the atmosphere using non-LTE model atmospheres calculated with TLUSTY/SYNSPEC. A comparison between the parallax distance measured by Hipparcos and the derived spectroscopic distance indicate that the derived atmospheric parameters are realistic. From our metal abundance analysis, we find a strong CNO signature and enrichment in iron and nickel.
Chemical fingerprints of He-sdO stars
Authors: Schindewolf Markus , Németh Peter , Heber Ulrich , Battich Tiara , Bertolami Marcelo M. Miller , Latour Marilyn
Published: March 2018

The chemical composition of helium-rich hot subluminous O stars plays an important role to understand and model their formation history. We present a spectroscopic analysis of four He-sdO stars,CD-31° 4800, [CW83] 0904- 02, LSS 1274 and LS IV +10° 9. The analysis is based on archival optical and UV high-resolution spectra. We used Tlusty200/Synspec48 to compute line blanketed non-LTE model atmospheres and their corresponding synthetic spectra and derive the atmospheric parameters as well as the abundances of the most prominent elements. All stars have helium-dominated atmospheres with hardly any hydrogen and temperatures between 42000 K and 47000 K while their surface gravity spans between log g = 5.4 and 5.7. CD-31° 4800 shows an enrichment of nitrogen and the characteristic pattern of hydrogen burning via the CNO-cycle, while the rest of the elements have about the solar abundance. This points to the slow merger of two helium white dwarfs as the most likely origin for this system. The other three stars are enriched in carbon, nitrogen and neon while their intermediate mass element’s abundance scatters around the solar value. They were possibly formed in the deep mixing late hot flasher scenario.
Secondary metabolites of Antarctic fungi antagonistic to aquatic pathogenic bacteria
Authors: Zhao Huibin , Cai Chuner , Liu Xiaoyu , Jiao Binghua , Chen Bo , Cai Menghao , He Peimin
Published: March 2018

Polar microbial derived antibiotics have potential as alternatives to traditional antibiotics in treating fish against pathogenic bacteria. In this paper, 23 strains of polar fungi were fermented to detect bacteriostatic products on three aquatic pathogenic bacteria, subsequently the active fungus was identified. It was indicated that secondary metabolites of 23 strains weredistinct; of these, the extract of strain B-7 (belonging toBjerkanderaaccording to molecular identification) demonstrated a strong antibacterial activity toStreptococcus agalactiae,Vibrio anguillarumandAeromonas hydrophilaATCC7966 by Kirby-Bauerpaper strip method. During one fermentation cycle, the pH curve of the fermentation liquor became lowest (4.0) on the 4thday and rose back to 7.6 finally after 5 days, The residual sugar curve was decreased before stablising on the 6thday. It is presumed that a large amount of alkaline secondary metabolites might have been produced during fermentation. This study focuses on antagonism between aquatic pathogenic bacteria and fermentation metabolites from Antarctic fungi for the first time, which may provide data on research of antibiotics against aquatic pathogenic bacteria.
Study of Seizure-Manifested Hartnup Disorder Case Induced by Novel Mutations in SLC6A19
Authors: Zhu Yanmei , Chen Li , He Jia , Chen Yan , Gou Haiyan , Ma Long , Qu Youyang , Liu Yu , Wang Di , Zhu Yulan
Published: March 2018

Aim

The aim of the study is to investigate a variation in the gene SLC6A19 in a female patient with Hartnup disorder manifested only by seizure.

Methods

DNA samples collected from the patient and her parents were analyzed and twelve exons of the SLC6A19 gene were amplified and sequenced.

Results

We found c.47C>T and c.1522G>A mutations in the gene SLC6A19 belonging to the patient, which are missense mutations inherited from her parents. The c.47C>T mutation is from her father and c.1522G>A is inherited from her mother. The parents are both heterozygous healthy carriers.

Conclusion

Two novel mutations of the SLC6A19 gene are revealed in the female patient with Hartnup disorder, exhibiting no typical dermatologic problems, but having dramatic neurological symptoms.
Decoding Byzantine ekphraseis on works of art. Constantine Manasses’s description of earth and its audience
Authors: Foskolou Vicky
Published: March 2018

The study deals with ekphraseis on works of art and poses the question as to how far these texts can be a reliable source for the study or even the reconstruction of the artefacts they describe. Based on reception theory and readerresponse criticism, in the paper is proposed that as every text, byzantine ekphraseis on artworks presuppose an audience or readership, i. e. the one the author had in mind and on the basis of which he encoded his message. In order to decode this message and by extension to extract any information about the described works of art we must aim to discover their “intended reader”, and identify his or her “horizon of expectations. This proposal is tested in the study of a well known piece of this kind, Manasses’s description of a mosaic floor with a depiction of Earth. The author’s dialogue with the earlier tradition of ekphraseis, his readership’s “horizon of expectations” combined with historical facts, allow us to suppose that Manasses is describing a composition with Xenia scenes and an asarotos motif (unswept floor) created in the early byzantine period and preserved in the Great Palace of Constantinople up to the twelfth century.
The Global Economy in the 21st Century: Will the Trends of the 20th Century Continue?
Authors: Gomułka Stanisław
Published: March 2018

This paper compares three lists of basic ‘stylized facts’ of global economic growth and proposes a list of five ‘stylized trends’ that describe the main developments of the global economy in the 20th century. The author’s main purpose is to answer the question whether, in the light of the contemporary growth theory and demographic forecasts, these trends are likely to continue in the 21st century. Considering this theory, it is argued that the global economy rate of growth of the per capita gross domestic product (GDP) is likely to continue to be high in the first half of the current century, but decline significantly in the second half. This paper offers forecasts for the average growth rates during this century, and the levels by its end, of the per capita GDP for the technology frontier area (TFA) of the world, and for the countries outside the TFA. According to these forecasts, the strong divergence trend of the 19th and 20th centuries will be replaced by a strong convergence between the TFA and the other countries during the 21st century.
Studies on the flammability of polypropylene/ammonium polyphosphate and montmorillonite by using the cone calorimeter test
Authors: Hanna A.A. , Nour M.A. , Souaya E.R. , sherief M.A. , Abdelmoaty A.S.
Published: March 2018

Fire performance of polypropylene (PP) containing different percentages of ammonium polyphosphate (APP) with montmorillonite (Mt) or treated montmorillonite (MtT) was carried out by using the cone calorimeter test (CCT). Different samples from ammonium polyphosphate and montmorillonite were mixed with 90% polypropylene. The characterization of the prepared samples indicates that there is incorporation between the components of the samples. Heat release rate (HRR), peak heat release rate (PHRR), average heat release rate (Av-HRR), and time to ignition (TTI) of the samples were obtained from the cone calorimeter test. Also, the fire performance index (FPI) and the fire growth rate (FIGRA) were calculated. The interpretation of the curves and the parameters results from the cone calorimeter test which indicates that the addition of montmorillonite to APP increases its action as a flame retardant for PP. Moreover, the samples contain acid treatment montmorillonite showed an increase in the efficiency of ammonium polyphosphate when used. This result may be due to an increase in the SiO2 content by acid treatment.
Organic biocides hosted in layered double hydroxides: enhancing antimicrobial activity
Authors: Cruz Alejandra Santana , Flores Jorge , Guerra Roberto , Felipe Carlos , Lima Enrique
Published: March 2018

Samples of layered double hydroxides containing carbonates as compensating anions were prepared by the urea method. These LDHs were used as hosts of anions coming from pipemidic and nalidixic acid. XRD results confirm that these anions were hosted in the interlayer space of LDHs. Further, from27Al NMR MAS characterization of an interaction between the brucite-like layers and anions was suggested. Then the hybrids LDHs were used as biocide ofSalmonella typhiandEscherichia coli. The release profile of pipemidic and nalidixic anions from hybrid LDHs occurs for periods as long as 3.5 hours. The free-organic acid LDHs were not able to killS.Typhi, neitherE.coli. In contrast, the hybrids LDHs eliminate almost completely bacteria within short times.
Bioassay-directed fractionation of a blood coagulation factor Xa inhibitor, betulinic acid from Lycopus lucidus
Authors: Tan Yin-Feng , Wang Qiong , Gong Jing-Wen , Zhang Xu-Guang , Li Yong-Hui , Zhang Jun-Qing , Li You-Bin
Published: March 2018

Thrombosis is a major cause of morbidity and mortality worldwide and plays a pivotal role in the pathogenesis of several cardiovascular disorders, including acute coronary syndrome, unstable angina, myocardial infarction, sudden cardiac death, peripheral arterial occlusion, ischemic stroke, deep-vein thrombosis, and pulmonary embolism. Anticoagulants, antiplatelet agents, and fibrinolytics can reduce the risks of these clinical events. Especially, the blood coagulation factor Xa (FXa) inhibitor is a proven anticoagulant. Promoting blood circulation, using traditional Chinese medicine (TCM), for the treatment of these diseases has been safely used for thousands of years in clinical practice. Therefore, highly safe and effective anticoagulant ingredients, including FXa inhibitors, could be found in TCM for activating the blood circulation. One FXa inhibitor, a pentacyclic triterpene (compound 1, betulinic acid) characterized by IR, MS and NMR analyses, was isolated from the ethyl acetate fraction of Lycopus lucidus by bioassay-directed fractionation. Compound 1 exhibited an inhibitory effect on FXa with IC50 25.05 μmol/L and reduced the thrombus weight in an animal model at 25-100 mg/kg. These results indicate that betulinic acid could be the potential for anticoagulant therapy.
Synthesis, characterization, in-vitro antimicrobial properties, molecular docking and DFT studies of 3-{(E)-[(4,6-dimethylpyrimidin-2-yl)imino]methyl} naphthalen-2-ol and Heteroleptic Mn(II), Co(II), Ni(II) and Zn(II) complexes
Authors: Chioma Festus , Ekennia Anthony C. , Osowole Aderoju A. , Okafor Sunday N. , Ibeji Collins U. , Onwudiwe Damian C. , Ujam Oguejiofo T.
Published: March 2018

Heteroleptic divalent metal complexes [M(L) (bipy)(Y)]•nH2O (where M = Mn, Co, Ni, and Zn; L = Schiff base; bipy = 2,2’-bipyridine; Y = OAc and n = 0, 1) have been synthesized from pyrimidine Schiff base ligand 3-{(E)-[(4,6-dimethylpyrimidin-2-yl)imino]methyl} naphthalen-2-ol, 2,2’-bipyridine and metal(II) acetate salts. The Schiff base and its complexes were characterized by analytical (CHN elemental analyses, solubility, melting point, conductivity) measurements, spectral (IR, UV-vis, 1H and 13C-NMR and MS) and magnetometry. The elemental analyses, Uv-vis spectra and room temperature magnetic moment data provide evidence of six coordinated octahedral geometry for the complexes. The metal complexes’ low molar conductivity values in dimethylsulphoxide suggested that they were non-ionic in nature. The compounds displayed moderate to good antimicrobial and antifungal activities against S. aureus, P. aeruginosa, E. coli, B. cereus, P. mirabilis, K. oxytoca, A. niger, A. flevus and R. Stolonifer. The compounds also exhibited good antioxidant potentials with ferrous ion chelation and, 1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assays. Molecular docking studies showed a good interaction with drug targets used. The structural and electronic properties of complexes were further confirmed by density functional theory calculations.
M-Polynomials and Topological Indices of Dominating David Derived Networks
Authors: Kang Shin Min , Nazeer Waqas , Gao Wei , Afzal Deeba , Gillani Syeda Nausheen
Published: March 2018

There is a strong relationship between the chemical characteristics of chemical compounds and their molecular structures. Topological indices are numerical values associated with the chemical molecular graphs that help to understand the physical features, chemical reactivity, and biological activity of chemical compound. Thus, the study of the topological indices is important. M-polynomial helps to recover many degree-based topological indices for example Zagreb indices, Randic index, symmetric division idex, inverse sum index etc. In this article we compute M-polynomials of dominating David derived networks of the first type, second type and third type of dimension n and find some topological properties by using these M-polynomials. The results are plotted using Maple to see the dependence of topological indices on the involved parameters.
Assessing theory with practice: an evaluation of two aspectual-semantic classification models of gerundive nominalizations
Authors: Fonteyn Lauren
Published: March 2018

This study present a corpus-based comparison of two aspectual-sematic classification models proposed in theoretical literature (unidimensional vs. bidimensional) by applying them to a set of nominal and verbal gerunds from the Modern English period. It (i) summarises the differences between unidimensional and bidimensional classification models and (ii) the potential problems associated with them. Despite the difficulties of studying semantic aspect in Present-day as well as historical data, this study will argue that, (iii) at least for deverbal nominalization patterns, it is possible to take a bidimensional approach and maintain a clear distinction between, on the one hand,aspectfeatures of the nominalized situation (stativity/dynamicity, durativity/punctuality, and telicity/atelicity), andtemporal boundednessof that situation. The question of which semantic classification model to use, then, is not so much one of which one is practically feasible in a corpus analysis, but rather which one is best suited to describe the attested variation. In order to determine the best model (in terms of parsimony and descriptive accuracy), (iv) the models were compared by means of ‘akaike weights’. To describe the variation between nominal and verbal gerunds in Early and Late Modern English, the bidimensional model outperformed the unidimensional one, showing that (v) the aspectual-semantic distinctions between Modern English nominal and verbal gerunds are a matter of bothaspectandtemporal boundedness.
Hybrid Discontinuous Galerkin Discretisation and Domain Decomposition Preconditioners for the Stokes Problem
Authors: Barrenechea Gabriel R. , Bosy Michał , Dolean Victorita , Nataf Frédéric , Tournier Pierre-Henri
Published: March 2018

Solving the Stokes equation by an optimal domain decomposition method derived algebraically involves the use of nonstandard interface conditions whose discretisation is not trivial. For this reason the use of approximation methods such as hybrid discontinuous Galerkin appears as an appropriate strategy: on the one hand they provide the best compromise in terms of the number of degrees of freedom in between standard continuous and discontinuous Galerkin methods, and on the other hand the degrees of freedom used in the nonstandard interface conditions are naturally defined at the boundary between elements. In this paper, we introduce the coupling between a well chosen discretisation method (hybrid discontinuous Galerkin) and a novel and efficient domain decomposition method to solve the Stokes system. We present the detailed analysis of the hybrid discontinuous Galerkin method for the Stokes problem with nonstandard boundary conditions. The full stability and convergence analysis
of the discretisation method is presented, and the results are corroborated by numerical experiments.
In addition, the advantage of the new preconditioners over more classical choices is also supported by numerical experiments.
An Autonomous Residential Smart Distribution Board: A Panacea for Demand Side Energy Management for Non-Smart Grid Networks
Authors: Olakanmi Oladayo O. , Adetoyi Oluyemi , Fajemisin Oluwafemi
Published: March 2018

Despite the benefits of demand response in energy management, the non-existence of its key concepts; dynamic pricing and smart grid, in some countries makes its impracticable in these countries, therefore making energy management unattainable for their consumers. This paper proposed a Smart Distribution Board (SDB) using a priority model for energy management in non-smart grid network. An historical consumption signatures of user’s loads were used to develop a priority model for load units of the SDB. Performance comparison was carried out between the SDB and a conventional Distribution Board which has no level of intelligence. Results obtained indicated that the SDB correctly emulated the energy usage pattern of users, thereby ensuring load preference is maximally satisfied autonomously within a limited budgeted energy and period.
VP-fronting: Movement vs. dislocation
Authors: Ott Dennis
Published: March 2018

While VP-fronting in English has various properties that are generally taken to be hallmarks of$$\overline A $$-movement, other properties of the construction militate against an analysis in terms of displacement of VP to the clausal periphery. Such an analysis falls short of providing principled answers to the questions of why the trace of VP-fronting must be nominal, why certain kinds of morphological mismatches between the fronted VP and its trace are possible, why fronting of remnant VPs is impossible, and others. This article proposes an analysis of English VP-fronting – plausibly extending to English ’topicalization’ in general – based on the observation that the construction shares these non-movement properties with left-dislocation of VP in German. Connectivity effects, on such an approach, are the result of ellipsis. By assimilating VP-fronting to dislocation, the analysis furnishes principled explanations for the striking asymmetries between English-type VP-fronting (dislocation) and German-type VP-fronting ($$\overline A $$-movement).
Autenticidad y falseamiento en Respiración artificial, de Ricardo Piglia
Authors: Oliva Abarca Jesús Eduardo
Published: March 2018

En este artículo se examinan las formas en que la literatura, en específico, el género novelístico, recurre a procedimientos discursivos y estrategias textuales empleados en la elaboración de relatos factuales. El caso particular aquí analizado, la novela Respiración artificial, de Ricardo Piglia, se constituye a partir de textos de diferente naturaleza, cuya autenticidad es puesta constantemente en duda. El falseamiento al que estos textos son sometidos por medio de la ficción permitiría sostener la idea de que la novela de Piglia, al emplear las mismas herramientas de los relatos empíricos, problematiza las relaciones que la literatura establece con la realidad.
Fichte o Deleuze, ¿quién es el dogmático?
Authors: Ferreyra Julián
Published: March 2018

Fichte y Deleuze se interpelan recíprocamente cuando caracterizan -cada cual a su modo- al dogmatismo como el enemigo del pensamiento auténticamente filosófico. En este artículo, reconstruiremos y compararemos tales caracterizaciones para, a partir de ellas, interrogar a ambas ontologías y contemplarlas bajo una nueva luz. En Deleuze, se estudiará de qué manera el Yo al cual ubica -en todas sus dimensiones- en el plano empírico puede hacer afirmaciones no-dogmáticas acerca de los planos que son su condición trascendental: lo intensivo y lo virtual. En Fichte, se interpetará la célebre fórmula Yo = Yo no como una forma de la identidad sino de una inmanencia que nunca se cierra sobre sí misma, sino que produce eternamente la multiplicidad de lo real.
Claudia Rocha y Claudia Carranza (coords.). Los habitantes del encanto. Seres extraordinarios en comunidades indígenas de América, San Luis Potosí, El Colegio de San Luis / Secretaría de Cultura del Gobierno del Estado de San Luis Potosí, 2015.
Authors: Arranz Conrado J.
Published: March 2018

Claudia Rocha y Claudia Carranza (coords.). Los habitantes del encanto. Seres extraordinarios en comunidades indígenas de América, San Luis Potosí, El Colegio de San Luis / Secretaría de Cultura del Gobierno del Estado de San Luis Potosí, 2015, 197 pp.
La presencia de Dios en el castillo interior. En torno a la complementariedad de la antropología mística de Santa Teresa de Jesús y la antropología fenomenológica de Edith Stein
Authors: González  Suárez Lucero
Published: March 2018

El artículo tiene el propósito de mostrar los principales puntos de encuentro entre la antropología mística de Santa Teresa de Jesús y la antropología fenomenológica de Edith Stein, en lo tocante a la comprensión del alma. Se trata de exhibir la plena conformidad que existe entre el la antropología mística teresiana y la antropología fenomenológica de Stein. Esta meditación es la antropología filosófica por su objeto; fenomenología, por el método empleado; hermenéutica, porque el análisis se dirige fundamentalmente a tres construcciones textuales: Las moradas del castillo interior, Ser finito y ser eterno y El castillo del alma. La tesis que trataré de probar es que si la naturaleza humana se define por la apertura al misterio de Dios, la comprensión integral del ser humano tiene que considerar los testimonios místicos.
La integración de las artes a través de una propuesta didáctica en educación secundaria obligatoria: música, plástica y expresión corporal
Authors: Botella Nicolás Ana María , Adell Valero José Rafael
Published: March 2018

El presente artículo desarrolla una propuesta experimental para la integración de las artes: música, plástica y expresión corporal en el marco de la Educación Secundaria Obligatoria. Se trata de plantear una experiencia interdisciplinar que se pueda llevar a la realidad del aula de Secundaria y que permita desarrollar la creatividad y la sensibilidad artísticas, tomando como base el arte contemporáneo. El principal objetivo consiste en generar y construir un armazón metodológico (interdisciplinariedad, trabajo por proyectos y cooperación) sobre el que se puedan desarrollar experiencias activas y técnicas novedosas cuyo interés fomente la aproximación a la cultura. En este contexto, se antepone la realización del proceso pedagógico, al resultado que se obtendrá por medio de la experiencia. La esencia del proyecto radica en la integración de las diferentes artes para conseguir un propósito común, permitiendo así una mejor adecuación a los objetivos y contenidos del currículum oficial. Esta propuesta es posible desarrollarla en el aula y permite una mejor comprensión del fenómeno artístico: al no tratarlo como una isla con respecto a otras disciplinas y dotarlo de un significado es posible llegar a un arco más amplio de personalidades atendiendo, al mismo tiempo, una visión no unívoca del sentido del arte.
¿Por qué una publicidad ética? Las campañas más polémicas
Authors: Pellicer Jordá María Teresa
Published: March 2018

La publicidad tiene una gran importancia en la sociedad actual. Determina buena parte de nuestros actos y de nuestra forma de ser. De ahí la importancia de que ésta cumpla con las normas éticas, destacando de entre todas ellas la veracidad. El actual estado de cosas permite que la publicidad sea ejercida sin control por cualquier persona, en cualquier momento y sin garantías para el consumidor. Este, igualmente, se está viendo cada vez más bombardeado por información publicitaria constante y contradictoria, que hace difícil que pueda ejercer un juicio verdaderamente informado y sano con respecto a qué productos compra, como los compra y cuando. En esta situación, los derechos de los consumidores están tan amenazados como la imagen pública de la propia publicidad. Se pierde el respeto a la mentira como arma de convicción y se sacrifican los resultados a largo plazo a favor de tendencias cortoplacistas amparadas en pseudo-filosofías comerciales: se acosa al consumidor con marketing telefónico y digital, ante la falta generalizada de ideas y se buscan soluciones fáciles, en vez de acudir a la verdadera creatividad.  En este artículo se ofrecen razones que sustentan estas afirmaciones y que permiten apostar por una verdadera ética publicitaria.
Sensorimotor Representation of Speech Perception. Cross-Decoding of Place of Articulation Features during Selective Attention to Syllables in 7T fMRI
Authors: Archila-Meléndez Mario E. , Valente Giancarlo , Correia Joao M. , Rouhl Rob P. W. , van Kranen-Mastenbroek Vivianne H. , Jansma Bernadette M.
Published: March 2018

Sensorimotor integration, the translation between acoustic signals and motoric programs, may constitute a crucial mechanism for speech. During speech perception, the acoustic-motoric translations include the recruitment of cortical areas for the representation of speech articulatory features, such as place of articulation. Selective attention can shape the processing and performance of speech perception tasks. Whether and where sensorimotor integration takes place during attentive speech perception remains to be explored. Here, we investigate articulatory feature representations of spoken consonant-vowel (CV) syllables during two distinct tasks. Fourteen healthy humans attended to either the vowel or the consonant within a syllable in separate delayed-match-to-sample tasks. Single-trial fMRI blood oxygenation level-dependent (BOLD) responses from perception periods were analyzed using multivariate pattern classification and a searchlight approach to reveal neural activation patterns sensitive to the processing of place of articulation (i.e., bilabial/labiodental vs. alveolar). To isolate place of articulation representation from acoustic covariation, we applied a cross-decoding (generalization) procedure across distinct features of manner of articulation (i.e., stop, fricative, and nasal). We found evidence for the representation of place of articulation across tasks and in both tasks separately: for attention to vowels, generalization maps included bilateral clusters of superior and posterior temporal, insular, and frontal regions; for attention to consonants, generalization maps encompassed clusters in temporoparietal, insular, and frontal regions within the right hemisphere only. Our results specify the cortical representation of place of articulation features generalized across manner of articulation during attentive syllable perception, thus supporting sensorimotor integration during attentive speech perception and demonstrating the value of generalization.
Pengembangan Perangkat Pembelajaran Telaah Kurikulum Matematika 1 Mengintegrasikan Kreativitas dan Karakter Cerdas Melalui Pembelajaran Kooperatif Berbasis Asesmen Proyek
Authors: Asikin Muhammad , Rochmad Rochmad , Kurniasih Ary Woro
Published: March 2018

Tujuan penelitian ini adalah mengetahui bagaimana proses dan hasil pengembangan Perangkat Pembelajaran Telaah Kurikulum Matematika 1 Mengintegrasikan Kreativitas Dan Karakter Cerdas Melalui Pembelajaran Kooperatif Berbasis Asesmen Proyek. Penelitian ini merupakan penelitian pengembangan. Produk yang dikembangkan dan diuji cobakan dalam penelitian ini adalah perangkat pembelajaran Telaah kurikulum matematika 1 mengintegrasikan kreativitas dan karakter cerdas melalui pembelajaran kooperatif berbasis asesmen proyek.. Adapun model pengembangan perangkat yang akan digunakan pada penelitian ini adalah model yang dikembangkan oleh Plomp (1997). Perangkat yang dikembangkan kemudian divalidasi ahli dan diujicobakan. Model pembelajaran yang digunakan adalah pembelajaran kooperatif. Subjek penelitian ini mahasiswa Telaah Kurikulum Matematika 1 sebanyak 45 orang.Pengembangan perangkat pembelajaran telaah kurikulum matematika 1 mengintegrasikan kreativitas dan karakter cerdas melalui pembelajaran kooperatif berbasis asesmen proyek mengacu pada teori pengembangan yang dikemukakan oleh Plomp dengan fase-fase (1) investigasi awal, (2) Design, (3) Realisasi, dan (4) Tes, evaluasi, dan revisi. Perangkat yang dikembangkan meliputi penggalan silabus, (2) satuan acara perkuliahan, (3) kontrak perkuliahan, (4) instrumen penilaian kreativitas, (5) angket penilaian diri karakter cerdas, (6) instrumen penilaian pelaksanaan peer teaching, (7) lembar pengamatan kreativitas mahasiswa, (8) asesmen proyek (9) Tes matematika yang sesuai dengan dengan pembelajaran kooperatif dengan integrasi kreativitas dan karakter cerdas pada telaah kurikulum matematika 1 yang mengintegrasikan kreativitas dan karakter cerdas melalui pembelajaran kooperatif berbasis asesmen proyek. Hasil pengembangan Perangkat Pembelajaran Telaah Kurikulum Matematika 1 Mengintegrasikan Kreativitas dan Karakter Cerdas Melalui Pembelajaran Kooperatif Berbasis Asesmen Proyek diperoleh perangkat yang valid. Implementasi pengembangan Perangkat Pembelajaran Telaah Kurikulum Matematika 1 Mengintegrasikan Kreativitas dan Karakter Cerdas Melalui Pembelajaran Kooperatif Berbasis Asesmen Proyek menunjukkan praktis dan efektif.
Analisis Kemampuan Calon Guru Matematika Dalam Pengajuan Masalah Ditinjau dari Gaya Kognitif Field Independent dan Field Dependent
Authors: Abdara Amirulmukminin
Published: March 2018

Penelitian ini bertujuan untuk mendeskripsikan kemampuan calon guru matematika dalam pengajuan masalah ditinjau dari gaya kognitif field independent (FI) dan field dependent (FD). Terdapat dua subjek dalam penelitian ini, yaitu mahasiswa calon guru Pendidikan Matematika semester VI, IKIP Mataram. Gaya kognitif subjek ditentukan berdasarkan skor pemberian instrument GEFT dan kemampuan pengajuan masalah diperoleh melalui TPM dan wawancara. SFI dan SFD masing-masing mengajukan 10 masalah dari informasi berbentuk grafik dan kalimat verbal. Secara umum, kemampuan SFI lebih bagus dibandingkan SFD yaitu: (1) SFI mengajukan 7 masalah sementara SFD hanya mengajukan 5 masalah yang berkaitan dengan aritmetika sosial, (2) SFI mampu mengajukan masalah yang memenuhi semua unsur sintaksis dan semantik, sementara masalah yang diajukan SFD dari informasi grafik hanya memuat 2 unsur sintaksis dan 2 unsur semantik dan dan masalah yang diajukan dari informasi kalimat verbal masing-masing memuat 2 unsur sintaksis dan 3 unsur semantik, (3) SFI mengajukan 5 masalah, sementara SFD hanya mengajukan 1 masalah yang memuat data baru, (4) SFI mengajukan 2 masalah yang tidak bisa diselesaikan karena rasa penasaran, sementara SFD mengajukan 5 masalah yang tidak dapat diselesaikan karena kesalahan pemilihan kata, dan (5) SFI mengajukan masalah yang termasuk kategori mudah, sedang, dan sulit, sementara masalah yang diajukan SFD hanya masuk kategori masalah mudah.This is descriptive research with qualitative approach which has purpose to describe the skill of preserve teacher in problem posing observed from cognitive style of field independent (FI) and field dependent (FD). The subjects are two the mathematic students in the sixth semester, IKIP Mataram. Cognitive style of each subject was determined by giving GEFT instrument and to know the skill of preserve mathematics teacher in posing problem was obtained through TPM and interview. SFI and SFD each posed ten problems from graph information and verbal sentence. SFI has better skill in problem posing than SFD: (1) SFI posed seven problems, while SFD only posed five problems related to arithmetic, (2) on SFI, all problems which were posed fulfilled all syntaxes and semantic elements which had been decided. While, the graph information of SFD could only posed the information which showed two syntaxes elements and two semantic elements, and each posed problems of verbal sentence information has two syntaxes elements and three semantic elements, (3) SFI pose five new data, while SFD could only show one problem which contained new data, (4) SFI posed two unsolved problems because of wondering, while SFD posed five unsolved problems because of choosing words error, and (5) SFI posed problems were included in each easy, middle and difficult category, while SFD only posed problem in easy category.
Improvement Students� Spatial Ability and Self Confidence Through Inquiry Learning With Geogebra at SMA Negeri 19 Medan
Authors: Malau Tuti Mariani
Published: March 2018

This study aims to find out the difference of spatial ability and self confidence students improvement who were taught through inquiry learning model with GeoGebra (ILMG) and inquiry learning model without GeoGebra (ILMWG). The population of the study was the students at SMAN 19 Medan. The sample was the tenth grade students who randomly selected. Experimental 1 class were taught by ILMG and experimental 2 class were taught by ILMWG. The instruments of this study were spatial ability test and self confidence scale. The data were analyzed with the analysis of variance and Mann-Whitney analysis. In general, The results of the study shows that the improvement of students spatial ability and self confidence who were taught through ILMG higher than ILMWG.Penelitian ini bertujuan untuk melihat perbedaan peningkatan kemampuan keruangan dan percaya diri siswa yang diajar dengan model pembelajaran inkuiri berbantuan GeoGebra (MPIG) dan model pembelajaran inkuiri tanpa berbantuan GeoGebra (MPITG). Populasi dari penelitian ini adalah siswa-siswi SMA Negeri 19 Medan. Sampelnya adalah siswa kelas X yang dipilih secara acak. Kelas eksperimen 1 diajar dengan menggunakan MPIG dan kelas eksperimen 2 diajar dengan menggunakan MPITG. Instrumen penelitian ini adalah tes kemampuan keruangan dan skala percaya diri. Data dianalisis dengan menggunakan analisis kovarian dan uji Mann-Whitney. Hasil penelitian secara umum menunjukkan bahwa peningkatan kemampuan keruangan dan percaya diri siswa yang diajar melalui MPIG lebih tinggi daripada melalui MPITG.
Lietuvos socialinių verslų novatoriškumas ir darniosios inovacijos: socialinių verslininkių patirtys
Authors: Novelskaitė Aurelija , Pučėtaitė Raminta , Pušinaitė-Gelgotė Rasa
Published: March 2018

This paper focuses on the perceptions of women social entrepreneurs of in the field of innovativeness forms and sustainable innovations. It presents empirical findings derived from interviews (n=18) with women representatives of social businesses in Lithuania. An analysis of the interview materials reveals that women social entrepreneurs define innovativeness on both individual and organizational levels, but the definition of sustainable innovation was related to moreglobal contexts and technological advancement. The findings correspond to the results of previous works in the field. Thus, on the one hand, the findings denote the universality of the topic; on the other hand, this shows the validity of the Lithuanian study.
Vyras tėvas kaip socialinių paslaugų gavėjas: istorinės patirties raiška socialinio darbuotojo profesinėje komunikacijoje
Authors: Eidukevičiūtė Julija
Published: March 2018

Each community has social groups that are not affected by the measures of common social policy that help in ensuring family welfare. In those cases, families need an individual social worker’s help in order to integrate into the society, overcome exclusion and poverty. The modern approach to the family as the most important to a child and responsible for his/her social development, and therefore the relationship of the social workers with the family in the process of providing aid should essentially differ from that of the Soviet family welfare system, when the parents had to comply with the norms established by the state, comply with the state-defined ideology. The article aims to discuss how a social worker provides help to a man-father by constructing an interaction with the whole family. The article is built on a qualitative hermeneutical and methodological perspective, which allows us to highlight the importance of social communication and historical experience in the process of family help.

Keywords: fatherhood, social work, hermeneutics
Lyties dimensija socialiniame versle: Lietuvos socialinių verslininkių patirtys
Authors: Novelskaitė Aurelija , Pučėtaitė Raminta , Pušinaitė-Gelgotė Rasa
Published: March 2018

This paper explores how women – social entrepreneurs – perceive the mission of their social businesses and the effects of gender in the context of such businesses. An analysis of interviews (n=18) with representatives of social businesses in Lithuania reveals that the mission of a social business is either strongly pragmatic (in the organizations that have the legal status of a social enterprise), dissociated from social impact or a rather vague one but that emphasizes goodwill. Meanwhile, the gender dimension in social businesses is approached in rather stereotypical ways: the effect of gender is either ignored or interpreted by stereotypically separating the traditionally female (e.g., caring for and bringing up children) and male (e.g., engineering) fields of activities.