bluuebunny/crossref_metadata_2025 huggingface dataset:
PERSONNEL MANAGEMENT IN THE CONDITIONS OF SOCIAL RESPONSIBILITY OF THE ENTERPRISE
Authors: Харченко Тетяна , Жун Мао , Михайлик Руслана
Published: November 2021

Peculiarities of personnel management at enterprises, means of influencing the employee in the development of labor relations are determined. The comparative characteristics of the most important socially responsible business models are considered. Attention is paid to the importance of personnel responsibility policy. The role of the concept of social responsibility of personnel management, which is based on the integration and consideration of the bilateral relationship between social responsibility and personnel management, is indicated. It is concluded that the creation of purposeful principles of personnel management involves a clear management mechanism for goals and results, taking into account modern requirements and capabilities of consumers, the socio-psychological state of staff in the constant development of scientific and technological progress.
Domestic Violence in Immigrant Communities: Case Studies (Punjabi)
Authors: Chaze Ferzana , Osborne Bethany J. (Bethany Joy) , Medhekar Archana , George Purnima
Published: November 2021

This document contains excerpts from the book Domestic Violence in Immigrant Communities: Case Studies by Dr. Ferzana Chaze, Dr. Bethany Osborne, Ms. Archana Medhekar and Dr. Purnima George that have been translated into Punjabi so that a wider audience can access them. The book is a freely accessible educational resource to be used in training with social work and legal practitioners.

The translated case studies in this document are real life stories of immigrant women who have experienced domestic violence in Canada. The cases emerged from closed legal case files handled by Archana Medhekar Law Office and reflect the stories of racialized immigrant women who experienced domestic violence in Canada and who sought legal help. Permission to carry out this research was received from the Research Ethics Board of both Ryerson University and Sheridan College in June 2019. All cases included in this research took place within the past ten years and were closed for at least one year prior to the start of the research.

In addition to the case studies, included are questions for discussion with community groups on the topic of domestic violence. We hope you will find this tool useful as you engage your communities on issues around domestic violence.
Understanding of Financial Literacy as a Moderating Variable on the Effect of Financial Technology on Financial Inclusion in Lubuklinggau City, Indonesia
Authors: Martini Martini , Sardiyo Sardiyo , Septian Reza , Anggreni sy Devi , Nurdiansyah Deni
Published: November 2021

This study investigates the effect of fintech on financial inclusion, and financial literacy, it was able to influence financial literacy on financial inclusion in Lubuklinggau. The research was conducted by distributing questionnaires to eight districts in the city of Lubuklinggau with a total sample of 401 people who use fintech as the main requirement. Data analysis was carried out with WarpPLS to identify direct and indirect effects on the tested variables. Based on the results, the perception of the ease and effectiveness of using fintech does not affect financial inclusion in Lubuklinggau. People are still not familiar with fintech and consider fintech as a new financial system and not easy to use. The level of risk and interest in using fintech has a significant influence on the financial inclusion variable in the Lubuklinggau. The indirect analysis explains it proves that financial literacy is able to moderate perceptions of the ease of using fintech and reduce the risk of fintech itself on financial inclusion. However, financial literacy is not able to moderate the effectiveness of using fintech and interest in financial inclusion to use of fintech after understanding financial literacy, people become more selective in using fintech.
Karakteristik Kanker Payudara
Authors: Herawati Andi , Rijal Syamsu , Arsal Andi St Fahira , Purnamasari Reeny , Abdi Dian Amelia
Published: November 2021

Kanker payudara menempati urutan pertama jumlah kasus kanker sekaligus menjadi penyebab kematian terbesar akibt kanker di dunia setia tahunnya. Adapun fakto risiko yang erat kaitannya dengan peningkatan insiden kanker payudara yaitu jenis kelamin perempuan, usia > 50 tahun, riwayat keluarga dan genetik, riwayat penyakit payudara, riwayat mentruasi/menarche dini (<12 tahun) atau menopause lambat (>55 tahun), riwayat reproduksi (tidak memiliki anak dan tidak menyusui), hormonal, obesitas, konsumsi alkohol, riwayat radiasi dinding data, serta faktor lingkungan.
Aesthetic Sustainability
Authors: Lehtinen Sanna
Published: November 2021

This chapter provides a philosophical history of the categories through which people experience places and describe encounters. It asks us to consider whether what is considered attractive actually translates into the durable objects and practices needed for sustainability. Engaging the developing psychological science of ‘nudging’, the author finds a new use for design aesthetics to influence human behaviours and tastes so that decisions align with sustainability goals.
Imagining Godzilla: An Art Research Network Platform
Authors: Best Andy
Published: November 2021

This chapter is an extended contribution from a collection of artists headed by Andy Best and Merja Puustinen. Best and Puustinen’s project, ‘Imagining Godzilla’, turned their Polynesian-style sailing catamaran into a research vessel on the Baltic Sea. With other artists on board, the catamaran became a mobile platform for creative-research projects on topics ranging from undersea Internet cables, new materialist explorations of phosphate circulation, audio-visual technologies and knowledge, and performative/auto-ethnographic accounts that probe the boundaries of life on land and sea.
Effect of using isolated interannual and decadal time scales on the water balance of the Amazon basin
Authors: Moura RG , Correia FWS , Veiga JAP , Capistrano VB , Kubota PY
Published: November 2021

In this study, we evaluated the isolated effects of interannual and decadal time scales on the water balance of the Amazon basin. This research is interesting because it brings the dynamical response of water balance components to a particular ocean-scale variability. For this, we used the Brazilian Global Atmospheric Model (BAM) and SST filtering techniques. The impact of isolated interannual and decadal time scales was quantified for episodes of ENSO and the Atlantic dipole (AD). The results show that isolated interannual scales weaken the impacts of El Niño and La Niña on water balance components in the northern Amazon and northeastern Brazil. Such weakening is more evident in episodes of El Niño than in those of La Niña. This indicates that El Niño is more dependent on other time scales (in addition to interannual) than is La Niña. In relation to the Atlantic, a positive AD increases (decreases) precipitation in the northern (southern) Amazon basin in the experiment with all SST time scale variabilities. On the other hand, when the decadal scale is isolated, an increase in precipitation in the northern basin is not observed, losing the dipole pattern in the precipitation anomaly between the northern and southern Amazon basin. BAM is not sensitive to a negative AD when SST is isolated in the decadal scale. These results are important for monitoring the climate of humid tropical regions, mainly for the study of ENSO, since, according to recent research, these extreme events will be increasingly frequent and intense.
Ranunculus polyphyllus Willd. still grows in Slovakia
Authors: Dítě Daniel , Balla Miloš , Dítě Zuzana
Published: November 2021

Ranunculus polyphyllus is a Eurosiberian species of the Eurasian forest-steppe zone, extremely rare in the western part of its distribution range, in Central Europe. In Slovakia, this lowland semiaquatic plant has its westernmost border, where only a few historic locations are known, and which have not been confirmed since 1965: one on the Podunajská nížina Lowland and three on the Východoslovenská nížina Lowland. These records, however, do not include any vegetation data. The species has been recently rediscovered in Slovakia on the Východoslovenská nížina Lowland: one historical site was confirmed in 2020 in the periodically inundated pasture near Strážne settlement, and a second site was found in 2021 near Zemplínske Hradište in a flooded depression in intensively used agricultural land which was formerly used as rice fields. In its European range, this species has been observed only in natural wetlands, and its ability to occupy secondary habitats has not yet been reported. Here we provide new data on the recent occurrence of Ranunculus polyphyllus in Slovakia with regard to its vegetation and habitat conditions.
Contaminación físico química en zonas de fracking
Authors: Guerrero-Useda María Eugenia
Published: November 2021

A pesar del consenso científico hacia la necesidad de limitar el calentamiento global, la urgencia por la provisión autónoma de recursos energéticos ha llevado a muchos Estados a autorizar proyectos que aplican técnicas no convencionales de extracción de combustibles fósiles, como es el caso de la perforación horizontal y la fracturación hidráulica de esquisto de gran volumen. Aunque son pocos los estudios que presentan evidencias concluyentes, estas técnicas son acusadas de acarrear peligros al ambiente y la salud de las personas que trabajan y habitan zonas de fracking, de tal manera que los Estados están ante la disyuntiva de extender algunos años la autonomía energética exprimiendo hasta el final sus reversas de gas natural y petróleo, o buscar algún equilibrio con el planeta moviéndose hacia fuentes energéticas más sostenibles. A partir de la revisión de trabajos que presentan evidencias de contaminación física y química y otros impactos al ambiente en zonas donde se ha desarrollado la técnica del fracking, se presenta un panorama de riesgos para las personas que habitan cerca de plataformas de extracción y los peligros de desarrollar proyectos de fracking en zonas climáticas tropicales.
Mitigación de altas sensaciones térmicas del municipio Bosconia-Cesar a través de forestación con especies nativas.
Authors: Vanegas Padilla Angélica Patricia , Jurado-Fuentes Oriana Carolina , López-Hernández Ronny Javier , Gómez-González Jorge Eduardo
Published: November 2021

Las altas temperaturas o condiciones de sensación térmica revelan inestabilidad en la comunidad Bosconense debido a la presencia de elevados niveles en la zona urbana a causa de la contaminación vehicular, malas prácticas ambientales y topografía desventajosa, alcanzando niveles de “estrés térmico”. Se realizó análisis multitemporal de: humedad relativa, temperatura, velocidad del viento, puntos de calor y sensación térmica para los años 2000, 2010, 2015 y 2020. También una caracterización del suelo basada en bibliografías y ambientalistas locales, encontrando 20.694 ha’s deforestadas entre 2000-2020 en toda Bosconia. Se presentó metodología de forestación con especies nativas (Cañaguate, Mango, Puy y Roble) y metodología de monitoreo sobre las variables humedad relativa, radiación solar, temperatura y velocidad del viento para evaluar eficacia. Añadiendo monitoreo a la radiación solar para futuras investigaciones locales. Posteriormente, se implementó la forestación y socialización con actores públicos, privados y población aledaña sobre los beneficios y cuidados que deben tenerse, estableciendo los periodos e instrumentos para evaluar la mitigación.

High temperatures or thermal sensation conditions reveal instability in the Bosconense community due to the presence of high levels in the urban area due to vehicular pollution, bad environmental practices and disadvantageous topography, reaching levels of “thermal stress”. Multitemporal analysis of: relative humidity, temperature, wind speed, hot spots and thermal sensation was carried out for the years 2000, 2010, 2015 and 2020. Also, a characterization of the soil based on bibliographies and local environmentalists, finding 20,694 ha's deforested between 2000 -2020 throughout Bosconia. Afforestation methodology with native species (Cañaguate, Mango, Puy and Roble) and monitoring methodology on the variables relative humidity, solar radiation, temperature and wind speed were presented to evaluate efficacy. Adding solar radiation monitoring for future local research. Subsequently, afforestation and socialization with public and private actors and the surrounding population about the benefits and care that should be taken was implemented, establishing the periods and instruments to evaluate mitigation.
Факторная структура моторики учащейся молодежи
Authors: Ш. Х. Ханкельдиев , С. Р. Ураимов
Published: November 2021

В работе излагаются основы понимания существа дела, тех научных основ построения процесса, на которых строятся методические советы, делает оправданным их применение. Учитывая уровень теоретической подготовленности выпускников факультета физического воспитания по данной проблеме, авторы стремились быть максимально доступными при изложении закономерностей развития двигательных способностей. Чем больше проникает наука о физическом воспитании в сферу спорта, тем больше знаний необходимо для их осмысленного применения в практике работы педагога. Авторы стремились при изложении материала давать конкретные методические рекомендации по совершенствованию физических качеств и о методике их воспитания, что будет способствовать будущим учителям школьной системы образования, выпускникам факультетов физического воспитания расширить диапазон своих теоретических знаний в сфере изучаемого вопроса. Монография предназначена для студентов, аспирантов и преподавателей высших учебных заведений; всех, кто интересуется физическим воспитанием и спортом.
Implementasi Sistem Registration Authority dan Personal Security Environment menggunakan Smart Card
Authors: Guarddin Gladhi , Alwan Jundi Ahmad
Published: November 2021

Penelitian ini bertujuan untuk menghasilkan analisis, rancangan, dan prototipe Personal Security Environment (PSE) menggunakan smart card. Analisis dan rancangan dilakukan dengan berdasarkan peraturan perundangan tentang infrastruktur kunci publik (IKP) dan sertifikat elektronik, dokumen peraturan PSrE Induk, spesifikasi Konsorsium Smart Card Indonesia (KSCI). Analisis dan rancangan tersebut kemudian diimplementasikan menjadi sebuah prototipe sistem Registration Authority (RA) yang bertugas untuk melakukan pendaftaran sertifikat elektronik bagi pengguna dan melakukan penyimpanan ke dalam PSE berupa smart card berbasis chipset Xirka yang merupakan Kartu Tanda Mahasiswa (KTM) Universitas Indonesia. Hasil implementasi menunjukkan bahwa seluruh skenario pengujian berhasil dilaksanakan dengan catatan kunci privat dan sertifikat elektronik masih diimplementasikan di dalam field chipset Xirka yang diperuntukkan sebagai penyimpanan foto dan fingerprint.
THE CURRENT STATE OF THE IMPLEMENTATION OF IT-REAL ESTATE IN RUSSIA
Authors: Malygina Olesya I. , Popp Ekaterina A. , Yevsyukova Inna N.
Published: November 2021

The third digital revolution leads to the emergence of a huge amount of geospatial data. A digital double is a digital three-dimensional copy of a real-world environment in which all available geospatial data is presented in a geo-referenced and object-oriented manner. Semantically enriched three-dimensional models of cities with reference to artificial intelligence can become powerful centers of integrated information for computer spatial analysis of cities and their modern development as independent managed units.
CONSIDERATION OF THE IMPACT OF USE-RESTRICTED ZONES IN THE LAND VALUATION PROCESS: RATIONALE, MAIN PROBLEMS AND SOLUTIONS
Authors: Mezhuyeva Tatyna V. , Pichueva Ekaterina S.
Published: November 2021

The article substantiates the inclusion of the influence factor of use-restricted zones in the composition of price factors and analyzes the main problems that arise in the process of evaluating land plots located in these zones.
STATE CADASTRAL ASSESSMENT OF REAL ESTATE AND NATURAL RESOURCES IN THE DIGITAL ECONOMY OF RUSSIA (DEFINITION OF ECONOMIC STANDARDS FOR THE RATIONAL USE OF REAL ESTATE PROPERTIES AND NATURAL RESOURCES)
Authors: Vlasov Alexander D.
Published: November 2021

Methodological and organizational problems of accounting, appraisal of real estate objects and natural resources of Russia are posed. The technology of accounting and determination of economic standards for the rational use of real estate and natural resources in the digital economy of Russia based on artificial intelligence is proposed.
NEW OPPORTUNITIES OF THE APPLICATION OF THE THREE-DIMENSIONAL INVENTORY ON THE BUILT-IN TERRITORIES, ENSURING THE LEGAL RIGHTS OF PROPERTY OWNERS
Authors: Avrunev Evgeny I. , Vylegzhanina Valerija V. , Giniyatov Ilgiz A. , Timonov Viktor A.
Published: November 2021

The article discusses the possibility of using a unified digital information platform containing information about real estate in 3D format from a legal point of view within the framework of the integrated development of municipalities. The concept of a 3D parcel was further developed: it is proposed to introduce new concepts such as a valid 3D parcel, a potential 3D parcel, and a preferential 3D parcel. In addition, the possibility of managing the development of built-up urban areas within the framework of the renovation of dilapidated housing through integrated development of the territory taking into account the growth of the urban population is being considered.
CADASTRAL REGISTRATION AND EVALUATION OF AGRICULTURAL LAND PLOTS IN RUSSIA IN THE DIGITAL ECONOMY
Authors: Vlasov Alexander D.
Published: November 2021

Methodological and organizational problems of accounting, evaluation of real estate objects and natural resources of Russia are set, and ways of their solution in the digital economy are proposed.
FACTORS OF FORMATION OF REAL ESTATE VALUE
Authors: Ilyinykh Anastasiya L.
Published: November 2021

One of the most important prerequisites for the effective use of land resources and real estate objects is the correct determination of its cadastral or market value, which allows you to establish reasonable amounts of payments for land and real estate, primarily tax payments. The composition of the main factors of the formation of the value of real estate objects for the purposes of cadastral and market valuation is considered. The cost factors characteristic of residential premises are highlighted.
Анализ применения параметрического и непараметрического методов обработки на примере данных значений силы тяжести
Authors: Кобелева Наталья Николаевна , Бексултанова Зарина Баранкуловна
Published: November 2021

В статье рассматриваются результаты исследования применения непараметрической обработки геодезических измерениий. Выполнен сравнительный анализ параметрической и непараметрической оценки с результатами геодезических измерений на примере определения силы тяжести. Для реализации данного исследования использовалось программное обеспечение Statgraphics 18 и мастер диаграмм Microsoft Excel. По результам измерений вычислены такие характеристики как медиана, среднее арифметическое, стандартное отклонение и дисперсия, а также получены значения доверительных интервалов для измерений силы тяжести в расчете двухсот семидесяти отсчетов с сейсмозащитой и без сейсмозащиты. Приведены разности между полученной шириной доверительных интервалов для двух приемов, построены диаграммы, проведен анализ полученных результатов.
Анализ кадастровой оценки земельных участков в составе земель сельскохозяйственного назначения на территории Новосибирской области
Authors: Комиссаров Александр Владимирович , Репотецкая Милена Юрьевна , Арутюнов Денис Вадимович
Published: November 2021

В статье проведен анализ результатов государственной кадастровой оценки земель сельскохозяйственного назначения на территории Новосибирской области за 2020 год. Рассмотрена динамика кадастровой стоимости земельных участков в составе земель сельскохозяйственного назначения в разрезе муниципальных районов за 2015 и 2020 годы и выявлены основные недостатки результатов оценки земельных участков.
Применение геоинформационных технологий при мониторинге полосы отвода автомобильных дорог
Authors: Костеша Владимир Александрович , Колесникова Ирина Константиновна
Published: November 2021

Статья посвящена теме мониторинга полосы отвода автомобильных дорог с использованием геопортала, разработанного на базе Государственного университета по землеустройству. Рассмотрены основные проблемы, возникающие в процессе эксплуатации земельно-имущественного комплекса автомобильных дорог. Особое внимание уделено мониторингу использования земель в границах полосы отвода и придорожной полосы. Проанализировано влияние незаконных съездов и «залесения» полосы отвода на безопасность дорожного движения.
Проблемы и перспективы геопространственных данных при внедрении в цифровую экономику для управления территориями
Authors: Крюков Семен Михайлович , Ершов Анатолий Викторович
Published: November 2021

В статье приведены возможности применения геоинформационной системы QGIS при ведении землеустроительных и кадастровых работ. Описаны функциональные возможности продукта, а также программные модули и мобильное приложение, используемые при работе в данной сфере.
Проблемы и перспективы геопространственных данных при внедрении в цифровую экономику для управления территориями
Authors: Кузнецов Сергей Михайлович , Малыгина Олеся Игоревна
Published: November 2021

Развитие применения геопространственнх данных с использованием концепции интернета вещей является перспективным направлением, в котором уже начали работу ведущие компании в области геоинформационных услуг. В статье рассмотрены проблемы и перспективы геопространственных данных при внедрении в цифровую экономику для управления территориями. Особое внимание уделено программе «Цифровая экономика Российской Федерации», а также проблемам связанным с принятием управленческих решений: сокращением технических, политических и организационных барьеров.
Проблема утилизации отходов
Authors: Майманова Елена Аркадьевна , Бочкарева Ирина Ивановна
Published: November 2021

В результате постоянного роста численности населения, развития промышленности, повышения социально-экономических потребностей людей, увеличивается количество образующихся твердых отходов, которые при неправильном сборе, обезвреживании и хранении нарушают устойчивость экологических систем и тем самым наносят ущерб окружающей среде. В связи с этим изучение принципов и проблем обращения с отходами превращается в одну из актуальных тем экологических, социальных и экономических исследований.
Исследование изменений нормативно-правовой базы в сфере землеустройства
Authors: Митрофанова Наталья Олеговна , Добротворская Надежда Ивановна , Норкин Владимир Игоревич , Свирина Ангелина Сергеевна
Published: November 2021

В статье рассмотрены современные проблемы, связанные с использованием земельных ресурсов в России, в частности, современное состояние сфере землеустройства. Основная проблема заключается в снижении роли землеустройства как научного и производственного явления, что приводит к принятию необъективных решений по планировке территории, использования земельных ресурсов и в целом к снижению эффективности управления земельно-имущественным фондом страны.

Цель исследования заключается в рассмотрении изменений в законодательстве, регулирующем землеустройство. В результате исследования проведена оценка эффективности современных землеустроительных мероприятий, а также сравнение содержания двух федеральных законов. Сделаны выводы о положительных изменениях законодательства в сфере землеустройства.
К вопросу актуальности работ по установлению границ зон затопления и подтопления (на примере территории города Новосибирска)
Authors: Дубровский Алексей Викторович , Скоринская Елена Андреевна
Published: November 2021

В Российской Федерации только начинаются работы по установлению зон затопления

и подтопления. Законодательно установлено внесение сведений о границах этих зон в единый государственный реестр недвижимости. Однако, при этом существует ряд нормативно-правовых и технологических вопросов, которые не решены и работы по установлению зон затопления и подтопления не выполнены в полном объеме. В статье дано описание основных руководящих нормативных документов, а также показаны новшества, которые внесли данные законы для усовершенствования процедуры установления зон затопления и подтопления.
Актуальные особенности осуществления государственной регистрации прав на недвижимое имущество
Authors: Иваненко Полина Евгеньевна , Стегниенко Елена Сергеевна
Published: November 2021

В статье рассмотрена процедура подачи документов для государственной регистрации прав на недвижимое имущество в электронном виде, изучена статистика заявлений, поданных с помощью электронных ресурсов, в условиях пандемии. Разработана процессуальная схема осуществления государственной регистрации прав при подаче документов в электронном виде, выявлены недостатки существующей системы.
Кадастровый и бухгалтерский учет объектов недвижимости
Authors: Ильиных Анастасия Леонидовна , Скрылева Яна Сергеевна
Published: November 2021

Вопросы кадастрового и бухгалтерского учета объектов недвижимости важны для российских организаций, так как в составе активов многих из них такие объекты занимают значительную долю. Некорректный учет объектов недвижимости существенно искажает финансовую отчетность российских компаний и вводит в заблуждение заинтересованных пользователей. Объекты недвижимости – особые товары. В первую очередь, это связано с тем, что право собственности и другие вещные права на них, ограничение, возникновение, переход и прекращение этих прав подлежат государственной регистрации в Едином государственном реестре недвижимости после их кадастрового учета. При этом, права на имущество, подлежащие государственной регистрации, возникают с момента их регистрации.
The homeomorphism of Minkowski space and the separable complex Hilbert space: the physical, mathematical and philosophical interpretations
Authors: Penchev Vasil
Published: November 2021

A homeomorphism is built between the separable complex Hilbert space and Minkowski space by meditation of quantum information. That homeomorphism can be interpreted physically as the invariance to a reference frame within a system and its unambiguous counterpart out of the system. The same idea can be applied to Poincaré’s conjecture hinting at another way for proving it, more concise and meaningful physically. Furthermore, the conjecture can be generalized and interpreted in relation to the pseudo-Riemannian space of general relativity therefore allowing for both mathematical and philosophical interpretations of the force of gravitation due to the mismatch of choice and ordering. Mathematically, that homeomorphism means the invariance to choice, the axiom of choice, well-ordering, and well-ordering “theorem” and can be defined generally as “information invariance”. Philosophically, the same homeomorphism implies transcendentalism The fundamental concepts of “choice”, “ordering” and “information” unify physics, mathematics, and philosophy.
Deprem ve Çevresel Etkiler Altındaki Yığma Binaların Davranışı
Authors: Erdil Baris , Korkut Fuat , Aydın Mahsum , Yaltay Namık
Published: November 2021

Türkiye'nin doğu sınırında yer alan ve sürekli olarak sert hava koşulları etkisinde bulunan yığma yapılar 2020 yılında birden fazla depreme de maruz kalmışlardır. Aynı gün bölgeyi sarsan 5.9 büyüklüğündeki iki depreme ilave olarak 4 ay sonra bölgede bir deprem daha meydana gelmiştir. Depremlerin yanı sıra yılda 124 donma-çözülme döngüsü meydana gelmekte ve bölgede yaklaşık 103 gün kar ve yağmur görülmektedir. Hem sürekli hem de periyodik olarak uygulanan çevresel etkiler ve kısa sürede önemli olan depremler, yığma yapıların yapısal performansını önemli ölçüde etkilemektedir. Depremlerden sonra yapılan arazi araştırmalarında, binaların hiçbirinin mevcut yönetmeliklere uymadığı, temellerin ve duvarların çevresel etkiler nedeniyle hasar gördüğü ve bu hasarların sismik yükleme nedeniyle ya arttığı ya da yıkıma yol açtığı görülmüştür. Hasar gören binaların yanı sıra bazı binaların köşelerinden lokal olarak güçlendirildiği gözlemlenmiştir. Duvarların yanal kapasitesini artırmak için çatlak köşelere L şeklinde betonarme kolonlar eklenmiştir. Bu tarz bir güçlendirmenin uygulandığı binaların bahsi edilen depremlerde hasar görmemesi sebebi ile yöntemin düşük şiddetli depremler için uygun olabileceği görülmüştür.
Perencanaan Instalasi Penangkal Petir Pada Bangunan Industri Bengkel Pembuatan Mesin CV. Karya Brawijaya
Authors: Duanaputri Rohmanita , Ruwah Joto  , Sigi Syah Wibowo  , Fery Nova Dwi Prasetyo
Published: November 2021

Petir merupakan kejadian alam yang terjadi karena loncatan muatan listrik antara awan dan bumi. Kerusakan akibat sambaran petir yang ditimbulkan dapat membahayakan peralatanperalatan serta manusia yang berada di dalam gedung tersebut. Pada kondisi ini keharusan bagi gedung untuk memasang penangkal petir agar terhindar dari sambaran petir. Di era ini, industri Indonesia semakin berkembang pesat dan banyak menggunakan peralatan sistem dengan komponen listrik, khususnya di sebuah industri Bengkel Mesin Agroindustri CV. Karya Brawijaya. CV. Karya Brawijaya didirikan pada tahun 2009, merupakan sebuah industri yang memproduksi mesin agroindustri. Dalam perencanaan sistem proteksi eksternal metode yang banyak digunakan adalah metode penangkal petir konvensional dan elektrostatik, oleh karena itu untuk mengkaji lebih lanjut, hasil observasi yang telah dilakukan ke industri tersebut masih belum ada sistem penangkal petir sehingga penulis akan mencoba merencanakan dan membandingkan perencanaan kedua jenis penangkal petir yaitu penangkal petir Konvensional (Franklin) dan Elektrostatik (E.F. Lightning Protection System) dari segi perlindungan, teknis, ekonomis, kelebihan dan kekurangannya. Metode penelitian dan observasi dilakukan pada area gedung CV. Karya Brawijaya, dengan teknik pengumpulan data melalui observasi secara langsung, wawancara, dan studi literature, sehingga didapatkan data denah gedung (tinggi, lebar dan panjang bangunan) dan data hari guruh tahun 2019 (IKL 243) kemudian dengan data yang diperoleh digunakan untuk menghitung parameter-parameter dalam perencanaan instalasi penangkal petir sesuai standar dari SNI 07015-2004 dan PUIPP. Sehingga diperoleh hasil untuk perencanaan metode konvensional (Franklin) dengan penempatan terminasi udara menggunakan metode bola bergulir didapatkan 9 finial terpasang dengan bangunan dapat menahan arus sampai 160,06 kA dan untuk metode elektrostatik (E.F. Lightning Protection System) dengan 1 finial bangunan dapat menahan arus sampai 23,737 kA, dan bila melebihi nilai tersebut akan ditangkap penangkal petir.
New Insights Into Biopesticides: Solid and Liquid Formulations of Essential Oils and Derivatives
Authors: López María D. , Cantó-Tejero Manuel , Pascual-Villalobos María J.
Published: November 2021

Essential oils and derivatives have shown effective insecticidal activity against different agricultural pests. However, the use of these bioactive compounds can result in negative effects due to their high volatility and difficult handling. Both solid and liquid formulations of essential oils have been developed in recent years. Currently, there are some commercial products available in the market, but they are still scarce and mainly based on liquid formulations. Solid formulations developed through spray-drying, including complex or micro/nanospheres, present differences in encapsulation efficiency, particle size, and controlled release, depending mainly on the wall material or surfactant content. Spray-dried essential oils have clear advantages over liquid formulations in terms of biological protection and storage. However, liquid formulations are usually easier scaled and applied. This review focuses on the advances of essential oils in both solid and liquid formulations (focusing on nanoemulsions) and derivatives to allow for their proper use in agriculture.
Folic Acid–Modified miR-491-5p–Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1
Authors: Ju Guanqun , Liu Bing , Ji Mingfei , Jin Rui , Xu Xiaojian , Xiao Yongshuang , Li Jie , Xu Dongliang , Huang Yuhua , Hou Jianquan
Published: November 2021

Epoxide hydrolase 1 (EPHX1) has been reported to be related to the development of several tumors. However, the regulation of castration-resistant prostate cancer (CRPC) development by EPHX1 has not been reported. We used proteomic technology and found that the EPHX1 protein was highly expressed in CRPC tissues and the CRPC cell line C4-2. We performed screening and found that EPHX1 is a direct target of miR-491-5p. High miR-491-5p expression significantly reduced the EPHX1 level in C4-2 cells and inhibited C4-2 cell proliferation and migration. Zeolite imidazolate framework-8 (ZIF-8) has good thermal stability, a simple synthesis method, tumor site stability, and specific acid responsiveness. We synthesized ZIF-8 nanodrug vectors to deliver miR-491-5p into C4-2 cells. After loading miR-491-5p into ZIF-8, we modified the ZIF-8 surface with folic acid (FA) as the target group (FA@ZIF-8). Our synthesized nanodrug carrier showed less cytotoxicity to C4-2 cells even at 200 μg/ml. Modified FA could increase the efficiency of nanomaterial entry into C4-2 cells. FA@miR-491-5p@ZIF-8 could stably release miR-491-5p for a long period in both phosphate-buffered saline (pH 7.4) and acetate buffer (pH 4.8), and miR-491-5p was released faster at the beginning of the experiment in acetate buffer (pH 4.8). FA@miR-491-5p@ZIF-8 significantly reduced C4-2 cell proliferation and migration, and FA@miR-491-5p@ZIF-8 had a better effect than miR-491-5p alone. In vivo, FA@miR-491-5p@ZIF-8 significantly inhibited CRPC growth in nude mice. Overall, we verified that miR-491-4p regulated CRPC development by targeting EPHX1. The drug nanocarrier FA@miR-491-5p@ZIF-8 not only significantly reduced C4-2 CRPC cell proliferation and migration but also significantly inhibited CRPC growth. Our research provides a theoretical basis for treatment and treatment strategies for CRPC.
Gut-Evolved Candida albicans Induces Metabolic Changes in Neutrophils
Authors: Reales-Calderon Jose Antonio , Tso Gloria H. W. , Tan Alrina S. M. , Hor Pei Xiang , Böhme Julia , Teng Karen W. W. , Newell Evan W. , Singhal Amit , Pavelka Norman
Published: November 2021

Serial passaging of the human fungal pathogen Candida albicans in the gastrointestinal tract of antibiotics-treated mice selects for virulence-attenuated strains. These gut-evolved strains protect the host from infection by a wide range of pathogens via trained immunity. Here, we further investigated the molecular and cellular mechanisms underlying this innate immune memory. Both Dectin-1 (the main receptor for β-glucan; a well-described immune training molecule in the fungal cell wall) and Nod2 (a receptor described to mediate BCG-induced trained immunity), were redundant for the protection induced by gut-evolved C. albicans against a virulent C. albicans strain, suggesting that gut-evolved C. albicans strains induce trained immunity via other pathways. Cytometry by time of flight (CyTOF) analysis of mouse splenocytes revealed that immunization with gut-evolved C. albicans resulted in an expansion of neutrophils and a reduction in natural killer (NK) cells, but no significant numeric changes in monocytes, macrophages or dendritic cell populations. Systemic depletion of phagocytes or neutrophils, but not of macrophages or NK cells, reduced protection mediated by gut-evolved C. albicans. Splenocytes and bone marrow cells of mice immunized with gut-evolved C. albicans demonstrated metabolic changes. In particular, splenic neutrophils displayed significantly elevated glycolytic and respiratory activity in comparison to those from mock-immunized mice. Although further investigation is required for fully deciphering the trained immunity mechanism induced by gut-evolved C. albicans strains, this data is consistent with the existence of several mechanisms of trained immunity, triggered by different training stimuli and involving different immune molecules and cell types.
Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
Authors: Wang James Jiqi , He Zuowen , Yang Yan , Yu Bo , Wang Hong , Ding Hu , Cui Guanglin , Wang Luyun , Wang Dao Wen , Jiang Jiangang
Published: November 2021

Pheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate. This study explored the efficacy and safety of applying chlorpromazine on PMC patients. The study included seven patients (median age, 42 years; range, 14–57 years) diagnosed with pheochromocytoma. Four consecutive PMC patients were admitted to our critical care unit between 2016 and 2020 due to abdominal or waist pain, nausea, and vomiting. Their blood pressure (BP) fluctuated between 200–330/120–200 and 40–70/30–50 mmHg. Chlorpromazine (25 or 50 mg) was injected intramuscularly, followed by continuous intravenous infusion (2–8 mg/h). The patients' BP decreased to 100–150/60–100 mmHg within 1–3 h and stabilized within 3–5 days. Two weeks later, surgical tumor resection was successfully performed in all four patients. Similar clinical outcomes were also obtained in three patients with sporadic PMC reported in the literature who received chlorpromazine treatment, which reduced their BP readings from >200/100 mmHg to 120/70 mmHg. Our observations, combined with sporadic reports, showed that chlorpromazine efficiently controlled PMC. Thus, future studies on the use of chlorpromazine are warranted.
Winter Tick Burdens for Moose Are Positively Associated With Warmer Summers and Higher Predation Rates
Authors: Hoy Sarah R. , Vucetich Leah M. , Peterson Rolf O. , Vucetich John A.
Published: November 2021

Climate change is expected to modify host-parasite interactions which is concerning because parasites are involved in most food-web links, and parasites have important influences on the structure, productivity and stability of communities and ecosystems. However, the impact of climate change on host–parasite interactions and any cascading effects on other ecosystem processes has received relatively little empirical attention. We assessed host-parasite dynamics for moose (Alces alces) and winter ticks (Dermacentor albipictus) in Isle Royale National Park over a 19-year period. Specifically, we monitored annual tick burdens for moose (estimated from hair loss) and assessed how it covaried with several aspects of seasonal climate, and non-climatic factors, such as moose density, predation on hosts by wolves (Canis lupus) and wolf abundance. Summer temperatures explained half the interannual variance in tick burden with tick burden being greater following hotter summers, presumably because warmer temperatures accelerate the development of tick eggs and increase egg survival. That finding is consistent with the general expectation that warmer temperatures may promote higher parasite burdens. However, summer temperatures are warming less rapidly than other seasons across most regions of North America. Therefore, tick burdens seem to be primarily associated with an aspect of climate that is currently exhibiting a lower rate of change. Tick burdens were also positively correlated with predation rate, which could be due to moose exhibiting risk-sensitive habitat selection (in years when predation risk is high) in such a manner as to increases the encounter rate with questing tick larvae in autumn. However, that positive correlation could also arise if high parasite burdens make moose more vulnerable to predators or because of some other density-dependent process (given that predation rate and moose density are highly correlated). Overall, these results provide valuable insights about interrelationships among climate, parasites, host/prey, and predators.
Association Between Insulin-like Growth Factor-1 rs35767 Polymorphism and Type 2 Diabetes Mellitus Susceptibility: A Meta-Analysis
Authors: Zeng Qiaoli , Zou Dehua , Zeng Qiaodi , Chen Xiaoming , Wei Yue , Guo Runmin
Published: November 2021

Background: Insulin-like growth factor-1 (IGF-1) has been demonstrated to increase fatty acid β oxidation during fasting, and play an important role in regulating lipid metabolism and type 2 diabetes mellitus (T2DM). The rs35767 (T > C) polymorphism, a functional SNP was found in IGF-1 promoter, which may directly affect IGF-1 expression. However, the inconsistent findings showed on the IGF-1 rs35767 polymorphism and T2DM risk.

Methods: We performed a comprehensive meta-analysis to estimate the association between the IGF-1 rs35767 and T2DM risk among four genetic models (the allele, additive, recessive and dominant models).

Results: A total 49,587 T2DM cases and 97,906 NDM controls were included in the allele model, a total 2256 T2DM cases and 2228 NDM controls were included in the other three genetic models (the additive; recessive and dominant models). In overall analysis, the IGF-1 rs35767 was shown to be significantly associated with increased T2DM risk for the allele model (T vs. C: OR = 1.251, 95% CI: 1.082–1.447, p = 0.002), additive model (homozygote comparisons: TT vs. CC: OR = 2.433, 95% CI: 1.095–5.405, p = 0.029; heterozygote comparisons: TC vs. CC: OR = 1.623, 95% CI: 1.055–2.495, p = 0.027) and dominant model (TT + CT vs. CC: OR = 1.934, 95% CI: 1.148–3.257, p = 0.013) with random effects model. After omitting Gouda’s study could reduce the heterogeneity, especially in the recessive model (TT vs. CC + CT: I2 = 38.7%, p = 0.163), the fixed effects model for recessive effect of the T allele (TT vs. CC + CT) produce results that were of borderline statistical significance (OR = 1.206, 95% CI: 1.004–1.448, p = 0.045). And increasing the risk of T2DM in Uyghur population of subgroup for the allele model.

Conclusion: The initial analyses that included all studies showed statistically significant associations between the rs35767 SNP and type 2 diabetes, but after removing the Gouda et al. study produced results that were mostly not statistically significant. Therefore, there is not enough evidence from the results of the meta-analysis to indicate that the rs35767 SNP has a statistically significant association with type 2 diabetes.
Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis
Authors: Xu Huixuan , Yu Haiyan , Liu Lixiong , Wu Hongwei , Zhang Cantong , Cai Wanxia , Hong Xiaoping , Liu Dongzhou , Tang Donge , Dai Yong
Published: November 2021

Objective

Genetic studies on ankylosing spondylitis (AS) have identified more than 100 pathogenic genes. Building a bridge between these genes and biologically targeted therapies is the current research hotspot.

Methods

We integrated single-cell assaying transposase-accessible chromatin sequencing (scATAC-seq) and single-cell RNA sequencing (scRNA-seq) to explore the key genes and related mechanisms associated with AS pathogenesis.

Results

We identified 18 cell types in peripheral mononuclear cells from patients with AS and normal controls and summarized the cell-type-specific abnormal genes by scRNA-seq. Interestingly, we found that the pathogenic gene NFKB involved in AS progression originated from CD8+ T cells. Moreover, we observed an abnormal tumor TNF pathway mediated by abnormal expression of TNF, NFKB, FOS, JUN, and JUNB, and scATAC-seq results confirmed the abnormal accessible binding sites of transcriptional factors FOS, JUN, and JUNB. The final magnetic bead sorting and quantitative real-time PCR(RT-qPCR) confirmed that NFKB, FOS, JUN, and JUNB in CD8+ T cells differed in the AS group.

Conclusions

Our results revealed a possible mechanism by which NFKB abnormally regulates FOS, JUN, and JUNB and drives AS progression, providing a novel perspective from a single cell point of view in AS.
Immune Evasive Effects of SARS-CoV-2 Variants to COVID-19 Emergency Used Vaccines
Authors: Zhang Yandi , Banga Ndzouboukou Jo-Lewis , Gan Mengze , Lin Xiaosong , Fan Xionglin
Published: November 2021

Coronavirus disease 2019 (COVID-19) pandemic is a serious threat to global public health and social and economic development. Various vaccine platforms have been developed rapidly and unprecedentedly, and at least 16 vaccines receive emergency use authorization (EUA). However, the causative pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has continued to evolve and mutate, emerging lots of viral variants. Several variants have successfully become the predominant strains and spread all over the world because of their ability to evade the pre-existing immunity obtained after previous infections with prototype strain or immunizations. Here, we summarized the prevalence and biological structure of these variants and the efficacy of currently used vaccines against the SARS-CoV-2 variants to provide guidance on how to design vaccines more rationally against the variants.
Characterization of Circulating Androgens, Cortisol and Estrogens During Normal, Abnormal and False Pregnancy in Bottlenose Dolphins (Tursiops truncatus) Under Managed Care
Authors: Steinman K. J. , Montano G. A. , Robeck T. R.
Published: November 2021

The few hormone studies on bottlenose dolphin (Tursiops truncatus) pregnancy with different reproductive outcomes, e.g., normal birth, stillbirth and abortion, have mostly focused on progestagens or relaxin. However, recent analysis of androgens, glucocorticoids and estrogens has shown they are also biomarkers of cetacean pregnancy. Therefore, our objective was to examine circulating concentrations of androgens, glucocorticoids and estrogens during bottlenose dolphin pregnancies with different reproductive outcomes, including normal pregnancy (NORM, n = 27), failure to thrive (FTT, n = 17), perinatal loss (PNL, n = 20), early loss (EL, n = 12) and false pregnancy (FP, n = 16), to determine if they could be potential indicators of reproductive or fetal health. We analyzed longitudinal serum samples (n = 654) from 57 bottlenose dolphins and 92 reproductive events for testosterone, androstenedione, cortisol, estradiol and estrone conjugates. Testosterone concentrations were higher during EL compared to NORM and lower during FP at MID (day 121 – 240 post ovulation/conception) and LATE (day 241 – end of FP) stages (months post conception/ovulation [MPC, MPO] seven through ten, P < 0.05). During FTT, androstenedione concentrations were increased compared to NORM pregnancies in the EARLY and LATE stages (P ≤ 0.05), and concentrations were reduced during FP (P < 0.05). For cortisol, FTT pregnancies had higher concentrations compared to NORM during all stages (P < 0.05), while PNL had higher cortisol during EARLY and LATE stages (P < 0.05). Estradiol concentrations were lower for EL and FP compared to NORM (P < 0.05), while estrone conjugates were only reduced during FP (P < 0.05). Based on our results only cortisol may be a useful predictor of PNL, while both cortisol and androstenedione were useful for distinguishing FTT pregnancies. Similarly, both testosterone and estradiol during EL and FP were different from NORM. Our data indicate a suite of pregnancy specific hormone biomarkers to evaluate maternal and fetal health in bottlenose dolphins should include cortisol, androgens and estrogens. This research also highlights the importance on non-progestagen hormones as sentinels of cetacean pregnancy and fetal health.