bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutritional Status in Patients with Medication-Related Osteonecrosis of the Jaw (MRONJ)
Authors: Laimer Johannes , Höller Alexander , Pichler Ute , Engel Raphael , Neururer Sabrina B. , Egger Alexander , Griesmacher Andrea , Bruckmoser Emanuel
Published: May 2021

Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe side effect of mostly antiresorptive drugs. The aim of this prospective clinical study was to evaluate the nutritional status in MRONJ patients scheduled for surgical treatment (intraoral soft tissue closure). The following parameters were evaluated: body weight, body height, BMI, nutritional risk index (NRI), bioelectric impedance analysis (BIA), vitamins A, B12, D3, E, K1, folic acid, iron, total protein, transferrin, ferritin, prealbumin, albumin, and zinc. All subjects were admitted to hospital four to five days before surgery and sip-fed with Nutritia Fortimel Compact Protein in addition to regular oral food intake. During surgery, a nasogastric tube was inserted and only removed on hospital discharge five days postoperatively. A total of 58 patients could be included. Half of the MRONJ patients were identified to be at risk for malnutrition. Deficiencies regarding protein levels were revealed, whereas hardly any relevant deficits of micronutrients were noted. The intraoral wound healing four weeks post-surgery was highly satisfactory with a low dehiscence rate of intraoral mucosal sites. Of all parameters analyzed, the dehiscence rate at the last follow-up four weeks post-surgery was significantly influenced by vitamin K, transferrin, and ferritin levels (p = 0.030, p = 0.004, and p = 0.023, respectively). In conclusion, perioperative dietary counselling and appropriate nutritional therapy are important supportive measures in MRONJ patients scheduled for intraoral soft tissue closure.
A Case of Primary Ciliary Dyskinesia Caused by a Mutation in OFD1, Which Was Diagnosed Owing to Clostridium difficile Infection
Authors: Hasegawa Rina , Suzuki Shinji , Nishimata Shigeo , Kashiwagi Yasuyo , Inagaki Natsuko , Kawashima Hisashi
Published: May 2021

We report a Japanese 5-year-old boy with primary ciliary dyskinesia (PCD) which was diagnosed owing to Clostridium difficile (CD) infection caused by prolonged antibiotic exposure. He had intractable otitis media with effusion (OME) and had abdominal pain and diarrhea for 4 months after starting antibiotics administration. His stool contained CD toxin. After vancomycin treatment, his symptoms improved and his stools did not contain CD toxin. His past medical history included frequent pneumonia. We, therefore, performed electron microscopy of the biopsy specimen from his nasal mucosa and genetic testing, and he was diagnosed with PCD. PCD is a rare inherited genetic disease causing ciliary dysfunction, which is very difficult to diagnose because some children without PCD also develop the same symptoms. Therefore, children who have intractable OME, rhinosinusitis, frequent pneumonia, or bronchitis and are taking antibiotics for long periods of time should be checked for underlying diseases, such as PCD.
Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies
Authors: Lodewijckx Inge , Cools Jan
Published: May 2021

The cytokine interleukin-7 (IL-7) and its receptor are critical for lymphoid cell development. The loss of IL-7 signaling causes severe combined immunodeficiency, whereas gain-of-function alterations in the pathway contribute to malignant transformation of lymphocytes. Binding of IL-7 to the IL-7 receptor results in the activation of the JAK-STAT, PI3K-AKT and Ras-MAPK pathways, each contributing to survival, cell cycle progression, proliferation and differentiation. Here, we discuss the role of deregulated IL-7 signaling in lymphoid malignancies of B- and T-cell origin. Especially in T-cell leukemia, more specifically in T-cell acute lymphoblastic leukemia and T-cell prolymphocytic leukemia, a high frequency of mutations in components of the IL-7 signaling pathway are found, including alterations in IL7R, IL2RG, JAK1, JAK3, STAT5B, PTPN2, PTPRC and DNM2 genes.
Hexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide—Induced Apoptotic Toxicity
Authors: Meanti Ramona , Rizzi Laura , Bresciani Elena , Molteni Laura , Locatelli Vittorio , Coco Silvia , Omeljaniuk Robert John , Torsello Antonio
Published: May 2021

Hexarelin, a synthetic hexapeptide, exerts cyto-protective effects at the mitochondrial level in cardiac and skeletal muscles, both in vitro and in vivo, may also have important neuroprotective bioactivities. This study examined the inhibitory effects of hexarelin on hydrogen peroxide (H2O2)-induced apoptosis in Neuro-2A cells. Neuro-2A cells were treated for 24 h with various concentrations of H2O2 or with the combination of H2O2 and hexarelin following which cell viability and nitrite (NO2−) release were measured. Cell morphology was also documented throughout and changes arising were quantified using Image J skeleton and fractal analysis procedures. Apoptotic responses were evaluated by Real-Time PCR (caspase-3, caspase-7, Bax, and Bcl-2 mRNA levels) and Western Blot (cleaved caspase-3, cleaved caspase-7, MAPK, and Akt). Our results indicate that hexarelin effectively antagonized H2O2-induced damage to Neuro-2A cells thereby (i) improving cell viability, (ii) reducing NO2− release and (iii) restoring normal morphologies. Hexarelin treatment also reduced mRNA levels of caspase-3 and its activation, and modulated mRNA levels of the BCL-2 family. Moreover, hexarelin inhibited MAPKs phosphorylation and increased p-Akt protein expression. In conclusion, our results demonstrate neuroprotective and anti-apoptotic effects of hexarelin, suggesting that new analogues could be developed for their neuroprotective effects.
Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies
Authors: Abdildinova Aizhan , Kurth Mark J. , Gong Young-Dae
Published: May 2021

Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and also is widely used for the synthesis of peptidomimetics. Small molecules including heterocycles serve as a core for hundreds of drugs, including peptidomimetic molecules. This review covers solid-phase synthesis strategies for peptidomimetics molecules based on heterocycles.
Curcumin-Loaded Micelles Dispersed in Ureasil-Polyether Materials for a Novel Sustained-Release Formulation
Authors: Nicolau Costa Kammila Martins , Sato Mariana Rillo , Barbosa Tellys Lins Almeida , Rodrigues Meiry Gláucia Freire , Medeiros Ana Cláudia Dantas , Damasceno Bolívar Ponciano Goulart de Lima , Oshiro-Júnior João Augusto
Published: May 2021

Vulvovaginal candidiasis (VVC) is a vulvar/vaginal infection that affects approximately 75% of women worldwide. The current treatment consists of antimicrobials with hepatotoxic properties and high drug interaction probabilities. Therefore, this study aimed to develop a new treatment to VVC based on micelles containing curcumin (CUR) dispersed in a ureasil-polyether (U-PEO) hybrid. The physical-chemical characterization was carried out in order to observe size, shape, crystallinity degree and particle dispersion in the formulation and was performed by dynamic light scattering (DLS), scanning electron microscopy (SEM), X-ray diffraction (XRD) and through in vitro release study. The results of DLS and SEM exhibited micelles with 35 nm, and encapsulation efficiency (EE) results demonstrated 100% of EE to CUR dispersed in the U-PEO, which was confirmed by the DRX. The release results showed that CUR loaded in U-PEO is 70% released after 10 days, which demonstrates the potential application of this material in different pharmaceutical forms (ovules and rings), and the possibility of multidose based on a single application, suggesting a higher rate of adherence.
Targeted RNAi of BIRC5/Survivin Using Antibody-Conjugated Poly(Propylene Imine)-Based Polyplexes Inhibits Growth of PSCA-Positive Tumors
Authors: Jugel Willi , Aigner Achim , Michen Susanne , Hagstotz Alexander , Ewe Alexander , Appelhans Dietmar , Schackert Gabriele , Temme Achim , Tietze Stefanie
Published: May 2021

Delivery of siRNAs for the treatment of tumors critically depends on the development of efficient nucleic acid carrier systems. The complexation of dendritic polymers (dendrimers) results in nanoparticles, called dendriplexes, that protect siRNA from degradation and mediate non-specific cellular uptake of siRNA. However, large siRNA doses are required for in vivo use due to accumulation of the nanoparticles in sinks such as the lung, liver, and spleen. This suggests the exploration of targeted nanoparticles for enhancing tumor cell specificity and achieving higher siRNA levels in tumors. In this work, we report on the targeted delivery of a therapeutic siRNA specific for BIRC5/Survivin in vitro and in vivo to tumor cells expressing the surface marker prostate stem cell antigen (PSCA). For this, polyplexes consisting of single-chain antibody fragments specific for PSCA conjugated to siRNA/maltose-modified poly(propylene imine) dendriplexes were used. These polyplexes were endocytosed by PSCA-positive 293TPSCA/ffLuc and PC3PSCA cells and caused knockdown of reporter gene firefly luciferase and Survivin expression, respectively. In a therapeutic study in PC3PSCA xenograft-bearing mice, significant anti-tumor effects were observed upon systemic administration of the targeted polyplexes. This indicates superior anti-tumor efficacy when employing targeted delivery of Survivin-specific siRNA, based on the additive effects of siRNA-mediated Survivin knockdown in combination with scFv-mediated PSCA inhibition.
Crocetin as New Cross-Linker for Bioactive Sericin Nanoparticles
Authors: Perteghella Sara , Rassu Giovanna , Gavini Elisabetta , Obinu Antonella , Bari Elia , Mandracchia Delia , Bonferoni Maria Cristina , Giunchedi Paolo , Torre Maria Luisa
Published: May 2021

The nose-to-brain delivery route is used to bypass the blood–brain barrier and deliver drugs directly into the brain. Over the years, significant signs of progress have been made in developing nano-drug delivery systems to address the very low drug transfer levels seen with conventional formulations (e.g., nasal solutions). In this paper, sericin nanoparticles were prepared using crocetin as a new bioactive natural cross-linker (NPc) and compared to sericin nanoparticles prepared with glutaraldehyde (NPg). The mean diameter of NPc and NPg was about 248 and 225 nm, respectively, and suitable for nose-to-brain delivery. The morphological investigation revealed that NPc are spherical-like particles with a smooth surface, whereas NPg seem small and rough. NPc remained stable at 4 °C for 28 days, and when freeze-dried with 0.1% w/v of trehalose, the aggregation was prevented. The use of crocetin as a natural cross-linker significantly improved the in vitro ROS-scavenging ability of NPc with respect to NPg. Both formulations were cytocompatible at all the concentrations tested on human fibroblasts and Caco-2 cells and protected them against oxidative stress damage. In detail, for NPc, the concentration of 400 µg/mL resulted in the most promising to maintain the cell metabolic activity of fibroblasts higher than 90%. Overall, the results reported in this paper support the employment of NPc as a nose-to-brain drug delivery system, as the brain targeting of antioxidants is a potential tool for the therapy of neurological diseases.
Characteristics of Nonstatic Quantum Light Waves: The Principle for Wave Expansion and Collapse
Authors: Choi Jeong Ryeol
Published: May 2021

Nonstatic quantum light waves arise in time-varying media in general. However, from a recent report, it turned out that nonstatic waves can also appear in a static environment where the electromagnetic parameters of the medium do not vary in time. Such waves in Fock states exhibit a belly and a node in turn periodically in the graphic of their evolution. This is due to the wave expansion and collapse in quadrature space, which manifest a unique nonstaticity of the wave. The principle for wave expansion and collapse is elucidated from rigorous analyses for the basic nonstatic waves which are dissipative and amplifying ones. The outcome of wave nonstaticity can be interpreted in terms of the coefficient of the quadratic exponent in the exponential function appearing in the wave eigenfunction; if the imaginary part of the coefficient is positive, the wave expands, whereas the wave collapses when it is negative. Using this principle, we further analyze novel nonstatic properties of light waves which exhibit complicated time behaviors, i.e., for the case that the waves not only undergo the periodical change of nodes and bellies but their envelopes exhibit gradual dissipation/expansion as well.
The Effects of Biochar on Indigenous Arbuscular Mycorrhizae Fungi from Agroenvironments
Authors: Videgain-Marco María , Marco-Montori Pedro , Martí-Dalmau Clara , Jaizme-Vega María del Carmen , Manyà-Cervelló Joan Josep , García-Ramos Francisco Javier
Published: May 2021

The effects of biochar on soil–plant–microorganisms systems are currently being extensively investigated. Considering that arbuscular mycorrhizal fungi (AMF) play an essential role in nutrient dynamics, the present study aims at understanding vine shoot-derived biochar effects on AMF activity and the impact of their multiplication in soils on water-stress resistance of plants. Three agronomic tests were performed in greenhouse pots. The first experiment evaluated the effects of three factors: final pyrolysis temperature for biochar production (400 °C and 600 °C), application rate (0 weight-wt.- % as a control, 1.5 wt. %, and 3.0 wt. %) and texture of the growing media (sandy-loam and clay-loam origin) on AMF, microbial communities and phosphatase activity. In the second experiment, an indigenous consortium of AMF was multiplied through the solid substrate method and sorghum as a trap plant with biochar addition. This process was compared to a control treatment without biochar. Obtained inocula were tested in a third experiment with lettuce plants under different water irrigation conditions. Results from the first experiment showed a general increase in AMF activity with the addition of the biochar produced at 400 °C in the sandy-loam texture substrate. Results of the second experiment showed that the biochar addition increased AMF root colonization, the number of AMF spores and AMF infective potential. Results of the third experiment showed that biochar-derived AMF inoculum increased AMF root colonization, AMF spores, dry biomass and the SPAD index in a lettuce crop under low-water irrigation conditions.
Synthesis of a New Phosphonate-Based Sorbent and Characterization of Its Interactions with Lanthanum (III) and Terbium (III)
Authors: Wei Yuezhou , Salih Khalid A. M. , Hamza Mohammed F. , Fujita Toyohisa , Rodríguez-Castellón Enrique , Guibal Eric
Published: May 2021

High-tech applications require increasing amounts of rare earth elements (REE). Their recovery from low-grade minerals and their recycling from secondary sources (as waste materials) are of critical importance. There is increasing attention paid to the development of new sorbents for REE recovery from dilute solutions. A new generation of composite sorbents based on brown algal biomass (alginate) and polyethylenimine (PEI) was recently developed (ALPEI hydrogel beads). The phosphorylation of the beads strongly improves the affinity of the sorbents for REEs (such as La and Tb): by 4.5 to 6.9 times compared with raw beads. The synthesis procedure (epicholorhydrin-activation, phosphorylation and de-esterification) is investigated by XPS and FTIR for characterizing the grafting route but also for interpreting the binding mechanism (contribution of N-bearing from PEI, O-bearing from alginate and P-bearing groups). Metal ions can be readily eluted using an acidic calcium chloride solution, which regenerates the sorbent: the FTIR spectra are hardly changed after five successive cycles of sorption and desorption. The materials are also characterized by elemental, textural and thermogravimetric analyses. The phosphorylation of ALPEI beads by this new method opens promising perspectives for the recovery of these strategic metals from mild acid solutions (i.e., pH ~ 4).
Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers
Authors: Sharma Ameya , Puri Vivek , Kumar Pradeep , Singh Inderbir , Huanbutta Kampanart
Published: May 2021

Various systematic phases such as inflammation, tissue proliferation, and phases of remodeling characterize the process of wound healing. The natural matrix system is suggested to maintain and escalate these phases, and for that, microfibers were fabricated employing naturally occurring polymers (biopolymers) such as sodium alginate, gelatin and xanthan gum, and reinforcing material such as nanoclay was selected. The fabrication of fibers was executed with the aid of extrusion-gelation method. Rifampicin, an antibiotic, has been incorporated into a biopolymeric solution. RF1, RF2, RF3, RF4 and RF5 were coded as various formulation batches of microfibers. The microfibers were further characterized by different techniques such as SEM, DSC, XRD, and FTIR. Mechanical properties and physical evaluations such as entrapment efficiency, water uptake and in vitro release were also carried out to explain the comparative understanding of the formulation developed. The antimicrobial activity and whole blood clotting of fabricated fibers were additionally executed, hence they showed significant results, having excellent antimicrobial properties; they could be prominent carriers for wound healing applications.
Endochondral Ossification Induced by Cell Transplantation of Endothelial Cells and Bone Marrow Stromal Cells with Copolymer Scaffold Using a Rat Calvarial Defect Model
Authors: Xing Zhe , Jiang Xiaofeng , Si Qingzong , Finne-Wistrand Anna , Liu Bin , Xue Ying , Mustafa Kamal
Published: May 2021

It has been recently reported that, in a rat calvarial defect model, adding endothelial cells (ECs) to a culture of bone marrow stromal cells (BMSCs) significantly enhanced bone formation. The aim of this study is to further investigate the ossification process of newly formed osteoid and host response to the poly(L-lactide-co-1,5-dioxepan-2-one) [poly(LLA-co-DXO)] scaffolds based on previous research. Several different histological methods and a PCR Array were applied to evaluate newly formed osteoid after 8 weeks after implantation. Histological results showed osteoid formed in rat calvarial defects and endochondral ossification-related genes, such as dentin matrix acidic phosphoprotein 1 (Dmp1) and collagen type II, and alpha 1 (Col2a1) exhibited greater expression in the CO (implantation with BMSC/EC/Scaffold constructs) than the BMSC group (implantation with BMSC/Scaffold constructs) as demonstrated by PCR Array. It was important to notice that cartilage-like tissue formed in the pores of the copolymer scaffolds. In addition, multinucleated giant cells (MNGCs) were observed surrounding the scaffold fragments. It was concluded that the mechanism of ossification might be an endochondral ossification process when the copolymer scaffolds loaded with co-cultured ECs/BMSCs were implanted into rat calvarial defects. MNGCs were induced by the poly(LLA-co-DXO) scaffolds after implantation, and more specific in vivo studies are needed to gain a better understanding of host response to copolymer scaffolds.
Advances in Biofabrication for Tissue Engineering and Regenerative Medicine Applications
Authors: Domingos Marco , Moxon Sam
Published: May 2021

Biofabrication strategies continue to gain considerable interest in the efforts to develop methods for better replicating in vitro models of human tissues [...]
UV-Curable Bio-Based Polymers Derived from Industrial Pulp and Paper Processes
Authors: Pezzana Lorenzo , Malmström Eva , Johansson Mats , Sangermano Marco
Published: May 2021

Bio-based monomers represent the future market for polymer chemistry, since the political economics of different states promote green ventures toward more sustainable materials and processes. Industrial pulp and paper processing represent a large market that could advance the use of by-products to avoid waste production and reduce pollution. Lignin represents the most available side product that can be used to produce a bio-based monomer. This review is concentrated on the possibility of using bio-based monomer derivates from pulp and the paper industry for UV-curing processing. UV-curing represents the new frontier for thermoset production, allowing a fast reaction cure, less energy demand, and the elimination of solvent. The growing demand for new monomers increases research in the environmental field to substitute for petroleum-based products. This review provides an overview of the main monomers and relative families of compounds derived from industrial processes that are suitable for UV-curing. Particular focus is given to the developments reached in the last few years concerning lignin, rosin and terpenes and the related possible applications of these in UV-curing chemistry.
Fabrication and Characterization of Chitosan—Tamarind Seed Polysaccharide Composite Film for Transdermal Delivery of Protein/Peptide
Authors: Malviya Rishabha , Tyagi Anchal , Fuloria Shivkanya , Subramaniyan Vetriselvan , Sathasivam Kathiresan , Sundram Sonali , Karupiah Sundram , Chakravarthi Srikumar , Meenakshi Dhanalekshmi Unnikrishnan , Gupta Nandan , Sekar Mahendran , Sudhakar Kalvatala , Fuloria Neeraj Kumar
Published: May 2021

Transdermal drug delivery is used to deliver a drug by eliminating the first-pass metabolism, which increases the bioavailability of the drug. The present study aims to formulate the chitosan—tamarind seed polysaccharide composite films and evaluate for the delivery of protein/peptide molecules. Nine formulations were prepared and evaluated by using different parameters, such as physical appearance, folding endurance, thickness of film, surface pH, weight variation, drug content, surface morphology, percentage moisture intake and uptake, drug release kinetics, and drug permeability. The film weight variance was observed between 0.34 ± 0.002 to 0.47 ± 0.003 g. The drug level of the prepared films was found to be between 96 ± 1.21 and 98 ± 1.33μg. Their intake of moisture ranged between 2.83 ± 0.002 and 3.76 ± 0.001 (%). The moisture absorption of the films ranged from 5.33 ± 0.22 to 10.02 ± 0.61 (%). SEM images revealed a smooth film surface, while minor cracks were found in the film after permeation tests. During the first 4 days, drug release was between 13.75 ± 1.64% and 22.54 ± 1.34% and from day 5 to day 6, it was between 72.67 ± 2.13% and 78.33 ± 3.13%. Drug permeation during the first 4 days was 15.78 ± 1.23 %. Drug permeation (%) during the first 4 days was between 15.78 ± 1.23 and 22.49 ± 1.29 and from day 5 to day 6, it was between 71.49 ± 3.21 and 77.93 ± 3.20.
Machine Learning Based Optimization Model for Energy Management of Energy Storage System for Large Industrial Park
Authors: Gao Ying , Li Jigeng , Hong Mengna
Published: May 2021

Renewable energy represented by wind energy and photovoltaic energy is used for energy structure adjustment to solve the energy and environmental problems. However, wind or photovoltaic power generation is unstable which caused by environmental impact. Energy storage is an important method to eliminate the instability, and lithium batteries are an increasingly mature technique. If the capacity is too large, it would cause waste and cost would increase, but too small capacity cannot schedule well. At the same time, the size of energy storage capacity is also constrained by power consumption, whereas large-scale industrial power consumption is random and non-periodic. This is a complex problem which needs a model that can not only dispatch but also give a reasonable storage capacity. This paper proposes a model considering the cycle life of a lithium battery and the installation parameters of the battery, and the electricity consumption data and photovoltaic power generation data of an industrial park was used to establish an energy management model. The energy management system aimed to reduce operating costs and obtain optimal energy storage capacity, which is constrained by lithium battery performance and grid demand. With the operational cost and reasonable battery capacity as the optimization objectives, the Deep Deterministic Policy Gradient (DDPG) method, the greedy dynamic programming algorithm, and the genetic algorithm (GA) were adopted, where the performance of lithium battery and the requirement of power grid were the constraints. The simulation results show that compared with the current forms of energy, the three energy management methods reduced the cost of capacity and operating of the energy storage system by 18.9%, 36.1%, and 35.9%, respectively.
Multi-Dimensional Drought Assessment in Abbay/Upper Blue Nile Basin: The Importance of Shared Management and Regional Coordination Efforts for Mitigation
Authors: Bayissa Yared , Moges Semu , Melesse Assefa , Tadesse Tsegaye , Abiy Anteneh Z. , Worqlul Abeyou
Published: May 2021

Drought is one of the least understood and complex natural hazards often characterized by a significant decrease in water availability for a prolonged period. It can be manifested in one or more forms as meteorological, agricultural, hydrological, and/or socio-economic drought. The overarching objective of this study is to demonstrate and characterize the different forms of droughts and to assess the multidimensional nature of drought in the Abbay/ Upper Blue Nile River (UBN) basin and its national and regional scale implications. In this study, multiple drought indices derived from in situ and earth observation-based hydro-climatic variables were used. The meteorological drought was characterized using the Standardized Precipitation Index (SPI) computed from the earth observation-based gridded CHIRPS (Climate Hazards Group InfraRed Precipitation with Station) rainfall data. Agricultural and hydrological droughts were characterized by using the Soil Moisture Deficit Index (SMDI) and Standardized Runoff-discharge Index (SRI), respectively. The monthly time series of SMDI was derived from model-based gridded soil moisture and SRI from observed streamflow data from 1982 to 2019. The preliminary result illustrates the good performance of the drought indices in capturing the historic severe drought events (e.g., 1984 and 2002) and the spatial extents across the basin. The results further indicated that all forms of droughts (i.e., meteorological, agricultural, and hydrological) occurred concurrently in Abbay/Upper Blue Nile basin with a Pearson correlation coefficient ranges from 0.5 to 0.85 both Kiremt and annual aggregate periods. The concurrent nature of drought is leading to a multi-dimensional socio-economic crisis as indicated by rainfall, and soil moisture deficits, and drying of small streams. Multi-dimensional drought mitigation necessitates regional cooperation and watershed management to protect both the common water sources of the Abbay/Upper Blue Nile basin and the socio-economic activities of the society in the basin. This study also underlines the need for multi-scale drought monitoring and management practices in the basin.
Seasonal Trends in Movement Patterns of Birds and Insects Aloft Simultaneously Recorded by Radar
Authors: Shi Xu , Schmid Baptiste , Tschanz Philippe , Segelbacher Gernot , Liechti Felix
Published: May 2021

Airspace is a key but not well-understood habitat for many animal species. Enormous amounts of insects and birds use the airspace to forage, disperse, and migrate. Despite numerous studies on migration, the year-round flight activities of both birds and insects are still poorly studied. We used a 2 year dataset from a vertical-looking radar in Central Europe and developed an iterative hypothesis-testing algorithm to investigate the general temporal pattern of migratory and local movements. We estimated at least 3 million bird and 20 million insect passages over a 1 km transect annually. Most surprisingly, peak non-directional bird movement intensities during summer were of the same magnitude as seasonal directional movement peaks. Birds showed clear peaks in seasonally directional movements during day and night, coinciding well with the main migration period documented in this region. Directional insect movements occurred throughout the year, paralleling non-directional movements. In spring and summer, insect movements were non-directional; in autumn, their movements concentrated toward the southwest, similar to birds. Notably, the nocturnal movements of insects did not appear until April, while directional movements mainly occurred in autumn. This simple monitoring reveals how little we still know about the movement of biomass through airspace.
Comparing PlanetScope to Landsat-8 and Sentinel-2 for Sensing Water Quality in Reservoirs in Agricultural Watersheds
Authors: Mansaray Abubakarr S. , Dzialowski Andrew R. , Martin Meghan E. , Wagner Kevin L. , Gholizadeh Hamed , Stoodley Scott H.
Published: May 2021

Agricultural runoff transports sediments and nutrients that deteriorate water quality erratically, posing a challenge to ground-based monitoring. Satellites provide data at spatial-temporal scales that can be used for water quality monitoring. PlanetScope nanosatellites have spatial (3 m) and temporal (daily) resolutions that may help improve water quality monitoring compared to coarser-resolution satellites. This work compared PlanetScope to Landsat-8 and Sentinel-2 in their ability to detect key water quality parameters. Spectral bands of each satellite were regressed against chlorophyll a, turbidity, and Secchi depth data from 13 reservoirs in Oklahoma over three years (2017–2020). We developed significant regression models for each satellite. Landsat-8 and Sentinel-2 explained more variation in chlorophyll a than PlanetScope, likely because they have more spectral bands. PlanetScope and Sentinel-2 explained relatively similar amounts of variations in turbidity and Secchi Disk data, while Landsat-8 explained less variation in these parameters. Since PlanetScope is a commercial satellite, its application may be limited to cases where the application of coarser-resolution satellites is not feasible. We identified scenarios where PS may be more beneficial than Landsat-8 and Sentinel-2. These include measuring water quality parameters that vary daily, in small ponds and narrow coves of reservoirs, and at reservoir edges.
Day and Night Clouds Detection Using a Thermal-Infrared All-Sky-View Camera
Authors: Wang Yiren , Liu Dong , Xie Wanyi , Yang Ming , Gao Zhenyu , Ling Xinfeng , Huang Yong , Li Congcong , Liu Yong , Xia Yingwei
Published: May 2021

The formation and evolution of clouds are associated with their thermodynamical and microphysical progress. Previous studies have been conducted to collect images using ground-based cloud observation equipment to provide important cloud characteristics information. However, most of this equipment cannot perform continuous observations during the day and night, and their field of view (FOV) is also limited. To address these issues, this work proposes a day and night clouds detection approach integrated into a self-made thermal-infrared (TIR) all-sky-view camera. The TIR camera consists of a high-resolution thermal microbolometer array and a fish-eye lens with a FOV larger than 160°. In addition, a detection scheme was designed to directly subtract the contamination of the atmospheric TIR emission from the entire infrared image of such a large FOV, which was used for cloud recognition. The performance of this scheme was validated by comparing the cloud fractions retrieved from the infrared channel with those from the visible channel and manual observation. The results indicated that the current instrument could obtain accurate cloud fraction from the observed infrared image, and the TIR all-sky-view camera developed in this work exhibits good feasibility for long-term and continuous cloud observation.
Sequence Image Datasets Construction via Deep Convolution Networks
Authors: Jin Xing , Tang Ping , Zhang Zheng
Published: May 2021

Remote-sensing time-series datasets are significant for global change research and a better understanding of the Earth. However, remote-sensing acquisitions often provide sparse time series due to sensor resolution limitations and environmental factors such as cloud noise for optical data. Image transformation is the method that is often used to deal with this issue. This paper considers the deep convolution networks to learn the complex mapping between sequence images, called adaptive filter generation network (AdaFG), convolution long short-term memory network (CLSTM), and cycle-consistent generative adversarial network (CyGAN) for construction of sequence image datasets. AdaFG network uses a separable 1D convolution kernel instead of 2D kernels to capture the spatial characteristics of input sequence images and then is trained end-to-end using sequence images. CLSTM network can map between different images using the state information of multiple time-series images. CyGAN network can map an image from a source domain to a target domain without additional information. Our experiments, which were performed with unmanned aerial vehicle (UAV) and Landsat-8 datasets, show that the deep convolution networks are effective to produce high-quality time-series image datasets, and the data-driven deep convolution networks can better simulate complex and diverse nonlinear data information.
Airborne LiDAR-Derived Digital Elevation Model for Archaeology
Authors: Štular Benjamin , Lozić Edisa , Eichert Stefan
Published: May 2021

The use of topographic airborne LiDAR data has become an essential part of archaeological prospection, and the need for an archaeology-specific data processing workflow is well known. It is therefore surprising that little attention has been paid to the key element of processing: an archaeology-specific DEM. Accordingly, the aim of this paper is to describe an archaeology-specific DEM in detail, provide a tool for its automatic precision assessment, and determine the appropriate grid resolution. We define an archaeology-specific DEM as a subtype of DEM, which is interpolated from ground points, buildings, and four morphological types of archaeological features. We introduce a confidence map (QGIS plug-in) that assigns a confidence level to each grid cell. This is primarily used to attach a confidence level to each archaeological feature, which is useful for detecting data bias in archaeological interpretation. Confidence mapping is also an effective tool for identifying the optimal grid resolution for specific datasets. Beyond archaeological applications, the confidence map provides clear criteria for segmentation, which is one of the unsolved problems of DEM interpolation. All of these are important steps towards the general methodological maturity of airborne LiDAR in archaeology, which is our ultimate goal.
Optical Remote Sensing Image Denoising and Super-Resolution Reconstructing Using Optimized Generative Network in Wavelet Transform Domain
Authors: Feng Xubin , Zhang Wuxia , Su Xiuqin , Xu Zhengpu
Published: May 2021

High spatial quality (HQ) optical remote sensing images are very useful for target detection, target recognition and image classification. Due to the influence of imaging equipment accuracy and atmospheric environment, HQ images are difficult to acquire, while low spatial quality (LQ) remote sensing images are very easy to acquire. Hence, denoising and super-resolution (SR) reconstruction technology are the most important solutions to improve the quality of remote sensing images very effectively, which can lower the cost as much as possible. Most existing methods usually only employ denoising or SR technology to obtain HQ images. However, due to the complex structure and the large noise of remote sensing images, the quality of the remote sensing image obtained only by denoising method or SR method cannot meet the actual needs. To address these problems, a method of reconstructing HQ remote sensing images based on Generative Adversarial Network (GAN) named “Restoration Generative Adversarial Network with ResNet and DenseNet” (RRDGAN) is proposed, which can acquire better quality images by incorporating denoising and SR into a unified framework. The generative network is implemented by fusing Residual Neural Network (ResNet) and Dense Convolutional Network (DenseNet) in order to consider denoising and SR problems at the same time. Then, total variation (TV) regularization is used to furthermore enhance the edge details, and the idea of Relativistic GAN is explored to make the whole network converge better. Our RRDGAN is implemented in wavelet transform (WT) domain, since different frequency parts could be handled separately in the wavelet domain. The experimental results on three different remote sensing datasets shows the feasibility of our proposed method in acquiring remote sensing images.
Canopy Parameter Estimation of Citrus grandis var. Longanyou Based on LiDAR 3D Point Clouds
Authors: Liu Xiangyang , Wang Yaxiong , Kang Feng , Yue Yang , Zheng Yongjun
Published: May 2021

The characteristic parameters of Citrus grandis var. Longanyou canopies are important when measuring yield and spraying pesticides. However, the feasibility of the canopy reconstruction method based on point clouds has not been confirmed with these canopies. Therefore, LiDAR point cloud data for C. grandis var. Longanyou were obtained to facilitate the management of groves of this species. Then, a cloth simulation filter and European clustering algorithm were used to realize individual canopy extraction. After calculating canopy height and width, canopy reconstruction and volume calculation were realized using six approaches: by a manual method and using five algorithms based on point clouds (convex hull, CH; convex hull by slices; voxel-based, VB; alpha-shape, AS; alpha-shape by slices, ASBS). ASBS is an innovative algorithm that combines AS with slices optimization, and can best approximate the actual canopy shape. Moreover, the CH algorithm had the shortest run time, and the R2 values of VCH, VVB, VAS, and VASBS algorithms were above 0.87. The volume with the highest accuracy was obtained from the ASBS algorithm, and the CH algorithm had the shortest computation time. In addition, a theoretical but preliminarily system suitable for the calculation of the canopy volume of C. grandis var. Longanyou was developed, which provides a theoretical reference for the efficient and accurate realization of future functional modules such as accurate plant protection, orchard obstacle avoidance, and biomass estimation.
Removal Mechanisms of Slag against Potentially Toxic Elements in Soil and Plants for Sustainable Agriculture Development: A Critical Review
Authors: Mehmood Sajid , Wang Xiukang , Ahmed Waqas , Imtiaz Muhammad , Ditta Allah , Rizwan Muhammad , Irshad Sana , Bashir Saqib , Saeed Qudsia , Mustafa Adnan , Li Weidong
Published: May 2021

Potentially toxic element (PTE) pollution is a major abiotic stress, which reduces plant growth and affects food quality by entering the food chain, and ultimately poses hazards to human health. Currently, the use of slag in PTE-contaminated soils has been reported to reduce PTEs and toxicity in plants. This review highlights the role of slag used as a fertilizer for better crop production and sustainable agricultural development. The application of slag increased the growth, yield, and quality of crops under PTE toxicity. The mechanisms followed by slag are the immobilization of PTEs in the soil, enhancement of soil pH, changes in the redox state of PTEs, and positive changes in soil physicochemical and biological properties under PTE toxicity. Nevertheless, these processes are influenced by the plant species, growth conditions, imposition length of stress, and type of slag used. The current review provides an insight into improving plant tolerance to PTE toxicity by slag-based fertilizer application and highlights the theoretical basis for applying slag in PTE-contaminated environments worldwide.
A Comprehensive Appraisal of the Wild Food Plants and Food System of Tribal Cultures in the Hindu Kush Mountain Range; a Way Forward for Balancing Human Nutrition and Food Security
Authors: Abdullah Abdullah , Khan Shujaul Mulk , Pieroni Andrea , Haq Aminul , Haq Zahoor Ul , Ahmad Zeeshan , Sakhi Shazia , Hashem Abeer , Al-Arjani Al-Bandari Fahad , Alqarawi Abdulaziz A. , Abd_Allah Elsayed Fathi
Published: May 2021

The tribal belt of the Hindu Kush mountains is famous for its unique culture, ethnography, wild food plants, food systems, and traditional knowledge. People in this region gather wild plants and plant parts using them directly or in traditional cuisine, or sell them in local markets. However, there is a huge lack of documentation of the food system, particularly that related to wild food plants (WFP). In the current study, we focus on the uses and contributions of WFPs in the traditional tribal food system of the Hindu Kush valleys along the Pakistan–Afghanistan border. Ethnobotanical data were gathered through questionnaire surveys of 84 informants, including 69 men and 15 women, belonging to 21 different villages of the chosen area. In tribal societies men and women rarely mix and thus very few women took part in the surveys. We documented 63 WFP species belonging to 34 botanical families, of which 27 were used as vegetables, 24 as fruits, six in different kinds of chutneys (starters), and six as fresh food species. Fruits were the most used part (41%), followed by leaves (24%), aerial parts (24%), seeds (7%), stems (3%), and young inflorescences (1%). The reported uses of Carthamus oxyacantha, Pinus roxburghii seeds, and Marsilea quadrifolia leaves are novel for the gastronomy of Pakistan. The results reveal that WFPs provide a significant contribution to local food systems and play a role in addressing human nutritional needs, which are usually not met through farming practices. The tribal peoples of the Hindu Kush use WFPs for their nutritional value, but also as a cultural practice—an inseparable component of the tribal community’s lifestyle. This important traditional knowledge about the gathering and consumption of WFPs, however, is eroding at an alarming rate among younger generations due to the introduction of fast-food, modernization, and globalization. Therefore, appropriate strategies are imperative not only to safeguard traditional plants and food knowledge and practices, as well as the cultural heritage attached to them, but also to foster food security and thus public healthcare via local wild foods in the region.
Conflicting Narratives of Deep Sea Mining
Authors: Hallgren Axel , Hansson Anders
Published: May 2021

As land-based mining industries face increasing complexities, e.g., diminishing return on investments, environmental degradation, and geopolitical tensions, governments are searching for alternatives. Following decades of anticipation, technological innovation, and exploration, deep seabed mining (DSM) in the oceans has, according to the mining industry and other proponents, moved closer to implementation. The DSM industry is currently waiting for international regulations that will guide future exploitation. This paper aims to provide an overview of the current status of DSM and structure ongoing key discussions and tensions prevalent in scientific literature. A narrative review method is applied, and the analysis inductively structures four narratives in the results section: (1) a green economy in a blue world, (2) the sharing of DSM profits, (3) the depths of the unknown, and (4) let the minerals be. The paper concludes that some narratives are conflicting, but the policy path that currently dominates has a preponderance towards Narrative 1—encouraging industrial mining in the near future based on current knowledge—and does not reflect current wider discussions in the literature. The paper suggests that the regulatory process and discussions should be opened up and more perspectives, such as if DSM is morally appropriate (Narrative 4), should be taken into consideration.
Social Controls and Bonds of Public Information Consumer on Sustainable Utilization and Provision for Computing
Authors: Hwang Kumju , Um Hyemi
Published: May 2021

In public areas, employees are both consumers and producers in information. For sustainable usage of information, employees should be aware of information systems security (ISS). Information systems security (ISS) is critical in further developing public sector information systems, such as e-government. Most ISS breaches are committed by insiders rather than outsiders. This study investigates the applicability of adult social bond theory, which proposes social controls in the form of social bonds that provide deterrence based on the potential shame an employee would feel from committing an ISS breach. The proposed research model consists of four antecedents for adult social bonds: commitment, attachment, belief and job stability. Individual ISS compliance is set as the dependent variance and deterrence and shame are set as the mediators between social bonds and compliance. Analysis of 672 data points largely supports the research model, proving the applicability to ISS of social bonds and social control. Belief seems to have the strongest effect on individual compliance. Implications are discussed and further studies are proposed.
Toward Sustainable Environmental Management of Healthcare Waste: A Holistic Perspective
Authors: Alharbi Nouf Sahal , Alhaji Jawaher Haji , Qattan Malak Yahia
Published: May 2021

The management of healthcare waste requires a sustained and holistic approach involving a range of parties. This is challenging for governments, especially in developing countries, where waste management systems have limited capacities for addressing the issue. Using Saudi Arabia as a case study, this paper followed a multi-method approach, including policy analysis, observation, semi-structured interviews, and a focus group, to explore the country’s healthcare waste management system. The study estimated that Saudi government hospitals across the country, every year, throw away in landfills paper (27,000 tons), plastic (15,000 tons), food (10,000 tons), glass (8000 tons), and metal (7000 tons). Regrettably, all these tons of materials end up in landfills without any form of recycling. A number of challenges were identified, reflecting mainly the lack of a legal framework, waste training, coordination among stakeholders, and social responsibility. This study generated new knowledge about waste management systems by exploring how their performance is shaped by the processes occurring at the policy, organization, and individual levels.