bluuebunny/crossref_metadata_2025 huggingface dataset:
An evidence-based guide to occlusion and articulation. Part 4: Unworn dentitions
Authors: Owen CP
Published: June 2022

SUMMARY AND PREAMBLE TO THE SERIESAlthough this is essentially a review, it has not been written in the passive, third-person style normally associated with scientific writing, as it is intended to be thought-provoking and, hopefully, educational. It has therefore been written in more of a conversational style, and is aimed at students, dentists and dental technicians who are receptive to a slightly different view of occlusion and articulation, based on evidence. Occlusion is a topic that has become a kind of archaic minefield of conflicting ideas, propositions, and above all, solutions, most of which are based on a complete lack of understanding of the evolution and development of teeth, and by extension, of clinically objective evidence. That in itself is a statement of conflict (and perhaps even heretical), but it is by way of warning that this guide is not going to be much like anything you will find in standard text-books of dentistry or dental technology. It is, rather, an attempt to help you navigate through what you will read elsewhere, in the hope that eventually you will find an understanding that you can live with. It will appear as a sequential series in 7 Parts.
What’s new for the clinician– summaries of recently published papers
Authors: Yengopal V
Published: June 2022

More than 90% of the world’s population suffer from one or more oral conditions that affects their oral health related quality of life. Edentulism (partial or full) is a major public health problem especially in poorer settings where people have limited options to manage tooth pain, tooth decay or periodontal disease. Often the only treatment option available is tooth extraction resulting in early tooth loss. In other settings, for example, the Western Cape, cultural and traditional norms practiced over generations has resulted in some of the highest edentulism rates in the world.

Placement of a stainless steel crown (SSC) is the most commonly recommended restoration following endodontic treatment of primary molars,1 as it provides a good coronal seal, preventing microbial infiltration or restoration failure over time. However, dental aesthetics are compromised due to colour characteristics of the SSCs, which may influence child's and parent's acceptance, especially when compared to more aesthetic options such as composite resins (CRs).
Probing Status Quo Bias in Dentistry
Authors: Sykes Leanne M , Babiolakis George P
Published: June 2022

The status quo bias in dentistry refers to a practitioner's preference for certain treatment modalities and resistance to contemplating the need for a change. Lack of updating skills and amending their work routine accordingly can result in them providing treatment that is dated or even totally obsolete. It could even be detrimental to their patient's oral health and open them up to the risk of litigation. The concept of Continuing Professional Development (CPD) was introduced to try enforce clinicians to improve their knowledge and skills, and keep abreast of current best practice recommendations. However, it should not be seen as a mere points collecting exercise that has little effect on bringing about changes in their work. Dentists need to continually review their work, and make adjustments when necessary in order to do better and be better. Only then canthey claim to be acting in their patients’ best interest and fulfilling their duty of beneficence.
Optimizing chronic inflammatory demyelinating polyneuropathy care with subcutaneous immunoglobulin: The Polyneuropathy and Treatment with Hizentra Open-Label Extension (PATH OLE) study and beyond
Authors: Mazen M. Dimachkie
Published: June 2022

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a heterogeneous, acquired autoimmune neurological disorder affecting peripheral nerves. CIDP is characterized by progressive weakness, reduced or absent tendon reflexes and impaired sensory function in the lower and upper limbs. CIDP diagnosis is mainly based on clinical, laboratory and electrophysiologic criteria and there are currently no diagnostic or prognostic biomarkers. First-line treatment options include corticosteroids, intravenous immunoglobulin (IVIg) and plasma exchange (PLEX). While IVIg and corticosteroids are the most common therapies administered for CIDP, there are challenges associated with their use, including systemic adverse events (AEs), some of which can be serious. Studies have shown that subcutaneous immunoglobulin (SCIg) may be associated with improved quality of life, which is attributed partially to the patients’ freedom to administer SCIg at home and at their convenience. While AEs with SCIg mostly consist of local site reactions, SCIg is associated with fewer systemic AEs compared with IVIg, and these are commonly mild, though severe reactions may rarely occur. A number of studies in the last decade have assessed SCIg in CIDP. One of these studies, the Polyneuropathy and Treatment with Hizentra® (PATH) study, was a global phase 3, double-blind, randomized, placebo-controlled trial that assessed the efficacy, safety, and tolerability of SCIg treatment in patients with CIDP. Based on the results of the PATH study, the US Food and Drug Administration (FDA) approved SCIg as a maintenance treatment for CIDP in 2018. This review summarizes and discusses the results of the PATH study and its open-label extension (OLE) study and provides an overview of the April 2021 update to the Hizentra® FDA-approved U.S. package insert based on findings from the PATH OLE. In addition, the review highlights key elements of the second revision of the European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) guideline for the diagnosis and treatment of CIDP. Finally, this review discusses the characteristics of patients with CIDP who may benefit from SCIg treatment.
Effects of Melatonin on Sleep Quality and Disease Activity in Patients With Rheumatoid Arthritis
Authors: Palimi Tayebeh , Zilaee Marzie , Rajaei Elham , Karandish Majid
Published: June 2022

Background and Objective In rheumatoid arthritis (RA) patients sleep disturbance is one of serious and prevalent problems. Considering the known effects of melatonin on sleep quality and inflammation, this study aimed to investigate melatonin supplementation effect on quality of sleep and disease activity in patients with RA.Methods In this randomized, placebo-controlled trial (double-blind), 64 RA patients were selected and divided into experimental and placebo groups randomly; experimental group received 3 mg/d of melatonin and another group consumed placebo for 60 days. Before and after the investigation, assessment of the quality of sleep determined using the Pittsburgh Sleep Quality Index (PSQI). Disease Activity Score-28 (DAS28) and the Visual Analogue Scale (VAS) questionnaires were used for evaluation of disease activity and pain intensity, respectively.Results Melatonin significantly reduced PSQI, DAS28 and VAS scores, when values compared with baseline. In contrast to placebo group, good sleep quality within the melatonin group increased significantly compared to baseline and this improvement in sleep quality was significant when compared between groups. The scores of DAS28 and pain VAS at the end of trial were significantly reduced compared to the baseline in both groups. However, reduction in the DAS28 and VAS scores of the melatonin group were stronger than reductions in the placebo receiving group.Conclusions This study results revealed that melatonin was safe and effective in improving sleep quality and reducing DAS28 and pain VAS scores in RA patients.
The Need for Titration With Polysomnography of Noninvasive Positive Pressure Ventilation in a Patient With Hypoventilation Syndrome With Kyphoscoliosis
Authors: Ji Ki-Hwan
Published: June 2022

Attended noninvasive positive airway pressure (PAP) with polysomnography (PSG) is recommended for determining the level of ventilatory support and bilevel PAP required for patients with chronic alveolar hypoventilation syndromes. We present a case of a 24-year-old male with kyphoscoliosis who presented with dyspnea. The patient was diagnosed with chronic alveolar hypoventilation and had bilevel PAP titrated by referring to tidal volume and arterial gas analysis during the day. After further titration with PSG there was stable ventilation during non-rapid eye movement sleep but unstable on entering rapid eye movement sleep.
RiboTag protocol for Brain Endothelial Cells v1
Authors: OH Won-Jong
Published: June 2022

Brain endothelial cells (BECs) are important conduits that deliver oxygen and nutrients, protect parenchyma cells from toxins, and drain wastes to maintain brain homeostasis. Impairment of BECs has been implicated in diverse neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Therefore, molecular analysis of BECs is important for understanding the molecular pathogenesis of these neurological diseases. Even though many transcriptome analyses for BECs have been developed, mRNA levels do not necessarily correlate with the levels of actively translated proteins. Translatome analysis using RiboTag mice, in which Rpl22, a ribosomal component, is tagged by the hemagglutinin epitope under Cre recombinase activation, could serve as an excellent tool that overcomes these caveats.However, implementation of this technique is limited by high noise-to-signal ratios as well as the low yield of mRNAs from BECs, which limits bulk gene expression analysis. In this study, we established a protocol to isolate highly pure mRNAs from BECs in the cortex of Tie2-Cre; Rpl22HA/HA mice by using a cell strainer to trap blood vessels prior to immunoprecipitation. According to the results of RT–PCR, the specificity of the mRNA pools isolated by our protocol was much higher than that of the pools isolated by the standard protocol. We were also able to generate a high-quality cDNA library for RNA-seq with the small amount of mRNA isolated with our protocol. Thus, this optimized method will be useful for future studies of BECs at the molecular level.
QGP-1 cell line maintenance protocol v1
Authors: not provided bellampalli.shreya
Published: June 2022

QGP-1 cell line maintenance protocol; thawing and passaging QGP-1 cells
[RETRACTED] https://www.facebook.com/PrimaKapselnDeutschland/ v1
Authors: not provided christophermsneed
Published: June 2022

[RETRACTED]

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SARS-CoV-2 Infection and Viral Replication of Human Lung Organoids v2
Authors: Baumgardt Morris
Published: June 2022

This protocol describes the working steps to infect human alveolar-like organoids with SARS-CoV-2 and quantify the viral replication at defined time points post infection via plaque assay and viral E gene quantitative reverse transcription PCR (RT-qPCR)
[RETRACTED] KetoXmed Liquid:-Work Or Hoax v1
Authors: not provided ketoxmedliquid
Published: June 2022

[RETRACTED]

That is where we come in. We will let you know everything to consider about KetoXmed before getting them! We need to cause explicit you to take full advantage of any enhancement you request. That infers being particularly educated prior to making an endeavor.
Integration von Betriebsdaten
Authors: Görtz Dennis , Hahnen Frank , Hanisch Felix , Hauer Markus , Neugebauer Torsten
Published: June 2022

Konzepte wie die NAMUR Open Architecture (NOA) beschreiben ein Rahmenkonzept, wie bislang ungenutzte Daten auf verschiedenen Ebenen der Automatisierungspyramide erschlossen werden können. Dabei werden häufige Engpässe der Datenkommunikation wie Steuerungen oder Leitsysteme umgangen, allerdings unter Beibehaltung bzw. Verbesserung der Cybersicherheit. Bei Bayer hat die immer engere Zusammenarbeit von IT- und OT-Funktionen die Entwicklung einer Datenintegrationslösung ermöglicht, die wir Data Integration Layer for Manufacturing IT (DIL4MIT) nennen. Sie folgt der NOA-Architektur und nutzt Werkzeuge, Lösungen und Servicekonzepte von IT-Dienstleistern in der Domäne der Prozessleittechnik, um Standorten und Anlagen weltweit Produktionsdatenkonnektivität auf effiziente Weise und mit voller Kostentransparenzermöglichen zu können. Dieser Beitrag beschreibt das DIL4-MIT-Konzept im Detail, zeigt die Analogie zu NOA auf und gibt einen Ausblick auf weitere Entwicklungen. Die Nutzung der so gewonnenen Daten wird an einzelnen Anwendungsfällen illustriert.
Bewertung von Wasserstoff- Wertschöpfungsketten
Authors: Beck Jan-Philip , Fay Alexander
Published: June 2022

Der Ausbau einer globalen Wasserstoffwirtschaft schreitet immer weiter voran. Damit H2 jedoch seine Rolle als substituierender Energieträger wahrnehmen kann, ist die Betrachtung von kompletten Wasserstoff-Wertschöpfungsketten unabdingbar. Dieser Beitrag stellt eine Methode vor, um gezielt verschiedene komplette Wasserstoff-Wertschöpfungsketten miteinander vergleichen zu können, ohne dabei beim Anwender ein umfangreiches Wissen aller notwendigen Einflussgrößen vorauszusetzen. Die Methode wird eingesetzt, um  exemplarisch drei Wertschöpfungsketten mit Hilfe von verschiedenen Bewertungskriterien zu bewerten.
Collection and Use of Information by Counter-Intelligence in the Context of Human Rights Protection
Authors: Dimich Antonina , Petrov Valentyn , Sliusarchuk Ivan , Mishchyshyn Nataliia , Fornolyak Valentyna
Published: June 2022

Obtaining complete and reliable information during counter-intelligence activities is very critical. The extraction, analytical processing, and use of information regarding signs and facts of intelligence, terroristic, and other activities of special services of foreign states, as well as organisations, individual groups, and individuals to the detriment of the state security of Ukraine is legally established as its main task. One of the main tasks of intelligence and counter-intelligence is to collect information in the interests of national security on the facts and signs of activities that threaten the sovereignty, territorial integrity, and constitutional order of the state, that is, its main system-forming component, using all possible sources. The purpose of such information collection is to assist the executive branch of government in developing internal and external policy, as well as to develop strategic and tactical decisions in the implementation of national policy. The purpose of this study was to identify the problems of collecting and using information by counter-intelligence, to develop a strategy to overcome such problems, and to investigate the legal principles of protecting human rights in the process of this activity. The results of the study will contribute to the development of the theory of national security, the obtained definition of the legal regime for collecting and using information about an individual or legal entity regarding which counter-intelligence actions are performed, will assist intelligence and counter-intelligence units in ensuring the protection of human rights during such activities.
Enforced Disappearance in Peru: A Step towards a National Policy to Search for Disappeared Persons
Authors: Serranò Agata
Published: June 2022

This paper aims to explore, firstly, what impact enforced disappearance -committed during the internal armed conflict which occurred between 1980 and 2000 in Peru - had on victims’ family members. Secondly, measures taken by the Peruvian State for the search, exhumation, identification and restitution of the remains of disappeared persons will be examined. Thanks to the analysis of 8 qualitative interviews with family members of disappeared persons and/or leaders of associations dedicated to supporting them, this paper will analyse the needs of family members of disappeared persons, which are still unmet and that constitute a future challenge for the Peruvian state.
Judicial Balacing of Parental Objection to Medical Treatment on the Basis of Religious Beleifs and Children Right to Life in Nigeria
Authors: Eyongndi David Tarh-Akong , Adeniji Samuel A.
Published: June 2022

Children being vulnerable, have special protection under the law through their parents or guardian who are responsible for them; and make decisions for them because they lack legal capacity. One of these decisions a parent/guardian makes is determining the religion of a child. Once the parent/guardian chooses the religion of the child, the child may become bound by its practices throughout childhood. While the right of parents to determine the religion of their children is recognised by domestic, regional and international laws, the way courts in Nigeria treat this recognition suggests that the right is not absolute. This paper adopts the doctrinal methodology in interrogating the extent to which Nigerian Courts permit the observation by a child of the religious practices of his/her parent in relation to submission to medical treatment in order to protect the child’s right to life. This paper argues that law and morality are media of social control but have their convergence and divergence. It further argues that sanctity of human life which for many forbids suicide, requires that even adults should not be allowed to object to medical treatment which refusal may result in death which can be seen as “disguised suicide.” These authors examined the Supreme Court decision in Medical Dental Practitioners Disciplinary Council v. Okonkwo and found that; Nigerian Courts recognise parent right to choose their children religion and practices however, any religious practice prejudicial to the child based on the “best interest” principle provided under the Child Right Act and its States equivalent will be jettisoned. It examines the practice in Britain and Canada and draw lessons for Nigeria. This paper recommends public enlightenment, prohibition of harmful religious beliefs such as objection to life-saving medical procedure by parents for minors as means of    balancing parents/guardian right to choose their children religious beliefs and preservation of the children right to life.
Feminism and Pornography: from mainstream pornography (hetero-patriarchal) to post-porn (non binary)
Authors: Valero Heredia Ana
Published: June 2022

Along with prostitution, and more recently surrogate motherhood, pornography has been a contentious issue within the feminist movement ever since the 1970s. Perceived by abolitionists as the prelude to rape, for pro-Sex feminists it represents an ideal vehicle for expressing desire for women and minority sexual identities, and has a considerable transformative capacity. The latter school of thought proposes a paradigm shift and has aligned itself with Queer Theory, which advocates a non-binary approach to sexual identities through Post-porn. This study critically analyses the main arguments put forward by feminism in the field of pornography: women's rights and the principle of no-harm.
Intersex Legal activism. United Nations on the Human Rights of Intersex People
Authors: Winter Pereira Luisa
Published: June 2022

For some years now, two intersex associations, Brújula Intersex and Stop Intersex Genital Mutilation, have been coordinating the participation in evaluation processes of the rights of intersex people convened by the United Nations. This article will try to analyse the legal strategies of these two associations to obtain the condemnation of several states by the United Nations. The ultimate goal is to draw a common thread of life stories, functioning of medical devices, silencing by governmental authorities, and possibilities for intersex people's agency.
Trans Rights: The Ongoing Debate in Latin American Legal Agendas
Authors: López Hidalgo Sebastián
Published: June 2022

This article offers an overview of the Trans people's rights agenda in Latin America. It focuses on various Latin American countries to reveal how the route towards rights has been marked by a binary and medicalizing approach to non-normative identities, directly influenced by the traditional and conservative moral projects prevalent in the region. It also accounts for some recent normative and case-law developments, which however coexist with restrictive norms that criminalize the rights of gender-diverse people. It concludes that the recognition of Trans people’s rights is often insufficient, that it contributes to rendering Trans diverse realities invisible, thus reinforcing discrimination.
The right to gender self-determination in Spain. Lessons from Autonomous Communities
Authors: Flores Anarte Laura
Published: June 2022

Law 3/2007, regulating the rectification of a person's official sex, is still in force in Spain. Although it does not demand reassignment surgery, it pathologizes the reassignment process, among other shortcomings. Since its enactment, 14 of Spain’s 17 Autonomous Communities (Regions) have legislated on the subject, mostly on the basis of self-determination, in an attempt to compensate for the perceived deficiencies in national legislation. This paper analyses and compares the legislative approach to gender identity and the rights of Trans people at a national and regional level.
A Curriculum-Based Approach to Learning Trajectories in Middle School Algebra
Authors: Martinez Mara V , Castro-Superfine Alison , Stoelinga Timothy
Published: June 2022

Our aim is to contribute to the body of research on learning trajectories (LTs) in mathematics by making visible a process for articulating a hypothetical learning trajectory implicit in a widely adopted, reform-based, middle-grades mathematics curriculum. In doing so, we highlight considerations, decisions, and challenges we faced as part of this work. By describing our LT articulation process, our aim is to highlight ways in which curriculum-specific LTs can be articulated to serve as a more proximal and instrumental tool for teachers’ instructional practice. Furthermore, to illustrate we describe how the products of the work were used in practice-based professional learning experiences with middle-grades mathematics teachers.
Medidas no convencionales en libros de texto mexicanos. Un análisis desde la Etnomatemática y el Enfoque ontosemiótico
Authors: Morales-Garcia Lizzet , Rodríguez-Nieto Camilo Andrés
Published: June 2022

El propósito de esta investigación fue el tratamiento de las unidades de medida no convencional promovidas en libros de texto de Matemáticas de la Educación Primaria en México. Se consideraron nociones teóricas y metodológicas del Programa Etnomatemática y el Enfoque Ontosemiótico (EOS). Como resultado se evidencia que, en los libros de texto se promueve el uso de unidades de medida de longitud (paso, codo, cuarta, dedo, vara, palmo, hilo o cordón y tira de papel); de capacidad (vaso y el molde de gelatina); de peso (sopeso, y balanza) y de tiempo (palmadas y reloj de arena).Donde las configuraciones epistémicas de objetos primarios permitieron caracterizar estas unidades de medida en términos de situaciones-problema, lenguaje, concepto-definición, procedimientos, proposiciones y argumentos. Se concluye que, las unidades de medida presentado en este estudio son el son el no convencional que ofrecen los materiales curriculares, para que los estudiantes y profesores, realicen procesos de medición, equivalencias y conversiones, así como resolver problemas extramatemáticos para contribuir al desarrollo de las competencias en torno al tema de la medida. Además, permite que el profesor reconozca la diversidad de unidades de medidas y las vincule con el contexto escolar de sus estudiantes.
Long-term complications after injuries of the male genitalia (results of a retrospective analysis)
Authors: Al-Vadzhikh M.A. A. , Vinogradov I. V. , Kapto A. A.
Published: June 2022

Genital injuries in men were most common among young people aged 18 to 45 (62.5 %). This is a group of able-bodied people and people who plan to have children. This makes this problem socially significant. Evaluation of the results and outcomes of treatment of injuries of the scrotum and penis should be carried out in a comprehensive manner. The assessment should assess the clinical component, radiation methods (ultrasound, ultrasound dopplerography, urethrocystography), disorders of spermatogenesis (spermogram), quality of life. The frequency of occurrence and severity of violations in all the designated groups of criteria for injuries of the scrotum organs correlate with the main assessment criteria – the degree of damage, the duration of the injury. The article presents the results of long-term consequences in patients after injuries of the genitals in men. The article also presents recommendations for the treatment of patients after injuries of the genitals in men, rehabilitation methods and recommendations for the medical examination of patients who have suffered injuries of the male genitals.
Efficacy of pure olive oil and PRF in the prevention of postoperative peritoneal adhesions
Authors: ALTINTAŞ URAL Dilan , ALTINTAŞ AYKAN Duygun , SEYİTHANOĞLU Muhammed , BAHAR Abdulkadir Yasir , KARAKAYA Ali Erdal , GÜLER Ahmet Gökhan
Published: June 2022

Purpose: In this study, we applied platelet rich fibrin (PRF) and pure olive oil on the incision surfaces of rats. We aimed to examine whether PRF may be used safely to prevent peritoneal adhesions.

Materials and Methods: Fourty rats were divided into 4 groups (n=8). Eight rats, not included in the study groups, were used to obtain PRF material. Group 1 had no surgical procedure, Group 2 was operated without medication, Group 3 was operated and received 1cc olive oil, Group 4 was operated and received 1 cc PRF. After 21 days, cecum areas were examined histopathologically. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and platelet-derived growth factor (PDGF) levels were measured in serum by ELISA.

Results: The adhesion scores and severity of fibrosis in Group 3 and 4 were significantly lower than Group 2. Plasma TNF-α value was significantly higher in Group 2 than Group 4. Plasma PDGF value was significantly higher in Group 2 than Group 3 and 4.

Discussion: PRF reduced intestinal adhesion by inhibiting the proliferation of fibroblasts and inflammatory cells, and promoting the proliferation of mesothelial cells. PRF has anti-inflammatory effect and prevented postop adhesions, based mainly on growth factors and cytokines in its content.
Effects of different endotracheal tube cuff pressures on dysphagia after anterior cervical spine surgery
Authors: URAL Sedef Gülçin , TÖR İbrahim Hakkı
Published: June 2022

of two different endotracheal cuff pressures on postoperative dysphagia, sore throat, dysphonia, and hospital stay in anterior cervical spine surgery.

Materials and Methods: Seventy patients scheduled for surgery were randomly divided into two groups. After intubation, the endotracheal cuff pressure was inflated to 20 cmH2O and 25 cmH2O in Group I (n=35) and Group II (n=35), respectively. The degree of dysphagia was assessed with the Bazaz dysphagia score. The sore throat was evaluated via Visual Analog Scale. Total pain score regarding the operation site was evaluated using VAS. Hoarseness was evaluated based on the presence of any changes to the voice asharsh or strained. Dysphagia, dysphonia, and sore throat were assessed on the post-surgical 1st and 24th hours.

Results: No differences in demographic data were present between the groups. Dysphagia and sore throat at the post-surgical 1st and 24th hours were significantly lesser in Group I than in Group II. The frequency of dysphonia was significantly less in Group I than compared to Group II only at the post-surgical 1st hour. No differences in VAS scores at the post-surgical 1st and 24th hours were present between the groups.

Conclusion: In this study, it was shown that the risk of developing dysphagia after surgery was significantly reduced with 20 cmH2O endotracheal cuff pressure compared to 25 cmH2O. Also, lower cuff pressure was associated with a milder sore throat, less hoarseness at 1 hour postoperatively, and a shorter hospital stay.
Effectiveness of the CLUE protocol in COVID-19 triage
Authors: ACAR Hüseyin , YAMANOĞLU Adnan , ARIKAN Cüneyt , BİLGİN Serkan , AKYOL Pınar Yeşim , KAYALI Ahmet , KARAKAYA Zeynep
Published: June 2022

Purpose: The purpose of this study was to evaluate the effectiveness of the CLUE protocol in COVID-19 triage.

Materials and Methods: Patients who presented to the emergency department due to dyspnea with oxygen saturation below 95 % and were diagnosed with COVID-19 by reverse transcription polymerase chain reaction (RT-PCR) tests were included in this prospective, observational study. Patients included in the study underwent lung ultrasound (LUS) in the light of the CLUE protocol, and were accordingly given LUS scores of between 0 and 36, also within the scope of the protocol. Patients were placed under observation, and clinical outcomes of discharge from the emergency department, admission to the ward, and admission to intensive care or discharge were recorded. ROC analysis was applied in the calculation of threshold values for LUS scores predicting discharge, admission to intensive care, and mortality.

Results: Forty-five patients with a mean age of 63 ± 18 years were included in the study. Fifteen patients (33 %) were treated on an outpatient basis and discharged, while 12 (27 %) were admitted to the ward and 18 (40 %) to the intensive care unit. Mortality occurred in 15 (33 %) patients. An LUS score lower than 3 was 97 % sensitive and 80 % specific for discharge, a score greater than 10 was 94 % sensitive and 78 % specific for admission to the intensive care unit, and a score higher than 11 was 93 % sensitive and 87 % specific for mortality. Based on regression analysis, an LUS score higher than 10 emerged as an independent risk factor for intensive care requirement, a score lower than 3 for discharge, and a score over 11 for mortality.

Conclusion: The CLUE protocol may be a useful bedside test in COVID-19 triage, and one that does not involve radiation or require laboratory tests.
Effect of geraniol and vitamin C on diethylnitrosamine induced experimental hepatocellular carcinogenesis
Authors: TAŞKIN ŞENOL Gamze , KAPLAN Halil Mahir , BOYAN Neslihan , OĞUZ Özkan , ŞİNGİRİK Ergin
Published: June 2022

Purpose: This study aimed to investigate the protective effect of geraniol and vitamin C on the experimental hepatocellular carcinogenesis (HCC) model by inducing FL83B hepatocyte cell lines with diethylnitrosamine (DENA).

Materials and Methods: The cells prepared in the medium were incubated with DENA (5 μM), geraniol (5 μM), and vitamin C (50 μM) for 48 hours in an incubator at 37 °C and 5% CO2. Groups were designed as follows: Group 1 (Control), group 2 (DENA Control), group 3 (DENA+Geraniol), group 4 (DENA+Vitamin C), and group 5 (DENA+Geraniol+Vitamin C) on standard cell culture plates. Six plates from each experimental group were studied. After the homogenization was centrifuged, analyses of pathway mediators NF-ĸB, AIF, caspase-3, BCL-2, bax, gadd153, GRP78, and COX were performed by the Elisa method.

Results: The expression of Bax, caspase-3, COX-2, NFkB, GADD153, AIF, and GRP78 increased in cancer cells when compared to group 1 and decreased in other groups where antiproliferative agents were applied. Bcl-2 expression is decreased when compared to group 1, and expression is increased in other groups where antiproliferative agents are applied.

Conclusion: There was a significant hepatoprotective effect in the groups administered geraniol+vitamin C on pathway mediators in a DENA-induced HCC model.
Development of ANCA-associated vasculitis after COVID-19 in a patient with Lynch syndrome and atypical hemolytic uremic syndrome
Authors: OZER Hakan , ÖZTÜRK Yasin , YÖNET Fethi
Published: June 2022

COVID-19 can be asymptomatic or cause very serious clinical pictures that can affect multiple systems. As the disease progresses, our clinical experience and the clinical presentations and management strategies we encounter also become more diverse and distinct. Anti Neutrophil Cytoplasmic Antibody (ANCA) positivity is particularly used as an indicator in the diagnosis of small vessel vasculitis such as granulomatous polyangitis, microscopic poliarteritis nodosa (m-PAN), and eosinophilic granulomatous polyangiitis (eGPA). ANCA-associated vasculitis can present with severe respiratory symptoms. Management of this group of patients is very difficult because COVID -19 pneumonia can very often be mistaken for these complaints and leads to serious limitations in the immunosuppressive treatment that should be used in the management of ANCA-associated vasculitis. At the beginning of the epidemic, our knowledge was limited by the increased susceptibility to infections and more severe disease in patients receiving immunosuppressive therapy for the combination of COVID -19 and vasculitic syndromes, whereas subsequently vasculitis cases were reported secondary to infections. In our case, the diagnoses of atypical hemolytic uremic syndrome (A-HUS) and Lynch syndrome were made, and the diagnosis of vasculitis due to new-onset ANCA positivity and alveolar hemorrhage after COVID -19 pneumonia was successfully treated with immunosuppressants.
Impact of Ergodic versus Nonergodic Seismic Hazard Estimation on the Risk Assessment of Liquefaction-Induced Ground Damage
Authors: Liu Chenying , Macedo Jorge
Published: June 2022

The seismic risk assessment of liquefaction-induced ground damage requires the hazard estimation of ground-motion intensity measures (IMs) through probabilistic seismic hazard analyses (PSHA). Current practice implements PSHA using ground-motion models (GMMs) developed under the ergodic assumption, which considers that the distribution of ground-motion IMs over time at a single site is the same as the distribution of ground-motion IMs over space. With the rapid growth of ground-motion databases, recent efforts have shown that ground-motion recordings are affected by location-specific systematic and repeatable effects favoring the transition to nonergodic approaches. However, the impact of using ergodic versus nonergodic PSHA (accounting for source, path, and site repeatable effects) on the risk assessment of liquefaction-induced damage has not been explored, which is the objective of this study. We consider three sites in California with different availability of ground-motion data to investigate the effects of the amount of available information on constraining repeatable effects and how this affects the final risk estimates within a nonergodic approach. In this context, the nonergodic-based estimates are compared against their ergodic counterparts, and insights are shared. The results from site-specific and regional assessments show important differences between ergodic and nonergodic estimates in terms of the mean risk and its uncertainty; the differences are dependent on the amount of data, and highlight the value of information (i.e., data) in nonergodic approaches.
Yulaf (Avena sativa L.) Tanelerinin Ultrasonik Destekli Etanolik Ekstraksiyonunun Toplam Antioksidan Kapasitesi, Radikal Süpürücü Aktivitesi ve Yağ Asidi Kompozisyonunun Belirlenmesi
Authors: ERDOĞAN Ümit , K. ERDOĞAN Gözde
Published: June 2022

Bu çalışmada yulaf tanelerinin ultrasonik destekli ekstraksiyonu ile elde edilen ekstraktların toplam antioksidan kapasitesi, serbest radikal süpürme aktivetisinin belirlenmesinin yanı sıra yulaf ekstraktının yağ asidi profili ve toplam tokoferol içeriğinin belirlenmesi amaçlandı. Bu amaçla, bakır iyonları (Cu2+) azaltıcı antioksidan güç testi (CUPRAC) metoduna göre yulaf taneleri ekstraktlarının toplam antioksidan kapasitesi belirlendi. Aynı zamanda, 1,1-difenil-2-pikril-hidrazil (DPPH•) yöntemine göre yulaf ekstraktlarının radikal süpürme kapasitesi araştırıldı. Yulaf ekstraktının yağ asidi komposizyonu GC-FID analizlerine göre belirlendi. Toplam tokoferol içeriği ise spektrofotometrik olarak belirlendi. Yulaf taneleri ekstraktının CUPRAC metoduna göre toplam antioksidan kapasitesi 1.5 ± 0.03 mmol TR /100g-yulaf taneleri ekstraktı olarak hesaplandı. Yulaf ekstraktının DPPH• radikali süpürme aktivitesi ise 2.02 ± 0.01 mmol TR /100 g – yulaf ekstraktı olarak hesaplandı. Yulaf özleri, güçlü antioksidan ve radikal süpürme yeteneği sergiledi. GC-FID sonuçları yulaf ekstraktının doymamış yağ asitlerince zengin olduğunu (Oleik asit, %43; Linoleik asit, %34) ortaya çıkardı. Yulaf taneleri ekstraktlarının toplam tokoferol içeriği ise 1376.3 ± 16 mg/kg-yulaf ekstrakt olarak bulundu.
Innovational Leadership: A new construct and validation of a scale to measure it
Authors: Contreras Francoise , Espinosa Juan Carlos , Dornberger Utz
Published: June 2022

Due to the current highly competitive business environment, companies need committed employees with innovative behaviors who contribute to innovation in the company. In this regard, we propose the construct Innovational Leadership, a specific style of leadership that promotes such manners. Likewise, we present the process of construction and validation of the Innovational Leadership Scale (ILS-16) through three sequential studies analyzing psychometric properties. These studies were conducted with different samples for a total of 367 employees. The results demonstrated that the ILS-16 is a valid and reliable unidimensional scale for assessing the proposed construct. This study involves scholars who will have the possibility to build new models, and also managers because ILS-16 constitutes a practical tool to measure innovational leadership in their companies.
Aportes de la psicología positiva a la creación y soporte de organizaciones saludables: revisión de alcance
Authors: Hernández Rincón Sandra Patricia , Aguilar Bustamante María Constanza , Peña-Sarmiento Martha del Rosario
Published: June 2022

La revisión proporciona una descripción del concepto y las propiedades asociadas a la organización saludable desde el enfoque de la psicología positiva. Para mapear la evidencia científica publicada entre el año 2011 y 2020, se empleó la metodología de revisión de alcance, y para examinar el contenido y las características metodológicas de las publicaciones, en esta revisión de alcance se efectuó un análisis temático. Dado que la mayoría de los estudios identificados hacen uso del modelo de organización saludable y resiliente, es evidente que existe un espacio significativo frente a su aplicación y beneficios, sobre todo en contextos latinoamericanos. Se discuten los desafíos de adoptar un marco conceptual de salud más integral, teniendo en cuenta el carácter multidimensional y dinámico de la salud, desde una perspectiva sistémica.
How to Take a Good Clinical History in Cases of Allergic Reactions to Medications
Authors: García-Avilés C , Martín-Lázaro J , Gastaminza G
Published: June 2022

The clinical history is the cornerstone of the doctor's work. When assessing patients consulting for a suspected hypersensitivity reaction to a drug, the details collected in the patient's clinical history are essential when deciding which tests to perform and for making recommendations about which drugs the patient should avoid and which can be taken. This area is especially important today, since many patients are labeled as allergic to drugs, especially penicillins, without this being the case. This article reviews the importance of the clinical history in a patient with a hypersensitivity reaction to a drug and considers which data should be collected. Likewise, a record-based model is proposed to help standardize the clinical history.
From the inside: Dancing between burnout and engagement in a prison
Authors: García-Callao Laura , Aenishänslin Bárbara , Rodríguez-Jiménez Rosa María
Published: June 2022

Objectives: Professionals who work in prisons present high levels of chronic stress that affect their daily performance and health. The incorporation of training workshops on emotional regulation and stress coping strategies from a psycho-body approach could have a positive impact on their well-being. This article presents an exploratory study that analyzes chronic stress, emotional repertoire and body awareness, of a sample of 15 professionals from a prison, together with the effect produced by an intervention through training workshops with Dance Movement Therapy. Material and method: A mixed methodology with a pretest-posttest design was used. The variables of burnout, engagement, emotional repertoire and body awareness were measured. With the information obtained from a participatory focus group, a six-hour body awareness program was designed and implemented, during which participants completed reflective diaries for subsequent analysis. Results: High levels of stress and low body awareness were found. Qualitative analysis generated evidence for improvements in body awareness and the incorporation of coping strategies based on listening to body sensations and emotional regulation. Pre-post test analysis for a subsample (n = 4) of the total showed improvements in different subscales, not statistically significant, but with medium effect sizes. Discussion: Despite the limitations of the study, the results are promising. The participants value the workshop very positively and consider having incorporated tools to cope with work stress.
Mental and behavioral disorders in the prison context
Authors: Gómez-Figueroa Helen , Camino-Proaño Armando
Published: June 2022

Introduction: During the execution of sentences in prison units, there are deficiencies within the adaptation mechanisms of persons deprived of liberty, this varies depending on the place where they serve the sanction and the length of stay in it. Objectives: To collect information on the prevalence of mental and behavioural disorders in the prison setting, as well as the importance of early psychiatric intervention. Material and method: Theoretical review. Primary sources of information: scientific articles from indexed journals, in specialized medical information search engines. Original publications on mental and behavioural disorders in the prison and prison context were included, from 2016 to April 2021, with an analytical, observational, prospective, retrospective, cross-sectional and randomized design, systematic reviews and meta-analyzes, complete articles, carried out in any country, with subjects over 15 years of age, of any sex or gender, in English and Spanish. Results: 16 articles were included in this theoretical review. The prevalence of mental disorders within the prison population is high; depression, anxiety, substance use and psychotic disorders predominate. The importance of having mental health programmes in prisons, with initial diagnosis and personalized interventions, was observed. The authors recommend psychopharmacological interventions and cognitive behavioural management. Discussion: The need to restructure the mental health approach in prisons was evidenced, and early diagnosis and personalized follow-up should be guaranteed. Pharmacological intervention and, to a greater degree, cognitive behavioural therapy seem to be effective for these types of patients.
The effect of drip irrigation on the formation of the root system of raspberry seedlings in the conditions of the Non-black soil zone of Russia
Authors: Dubenok N. N. , Ilchenko K. Yu. , Gemonov A. V.
Published: June 2022

Relevance. Currently, there is an acute problem of meeting the growing demand for berry and fruit products. One of the ways to intensify agricultural production in the field of horticulture and crop production is to increase the efficiency of environmental management through the use of resource-saving technologies. One of these technologies is drip irrigation, which improves the quality of crop production.

Materials and methods. Field studies were carried out on the territory of the educational and experimental farm of the laboratory "Michurinsky Garden" of the Russian State Agrarian University – Moscow Timiryazev Agricultural Academy. The experiment was established in the fall of 2018 and is a two-factor study of various levels of moisture on the growth and development of raspberry seedlings. The first factor included options for maintaining soil moisture in the range: 1) control (without irrigation); 2) not less than 60% of the lowest moisture capacity; 3) not less than 70% of the lowest moisture capacity; 4) not less than 80% of the lowest moisture capacity. The second factor was the raspberry varieties Solnyshko and Nagrada.

Results. Constructed moisture contours according to the study options showed that drip irrigation contributes to the optimum moisture concentration in the soil for seedlings. The most developed root system in comparison with the control was obtained on irrigated variants with maintaining a moisture content of at least 70 and 80% of the lowest moisture capacity. Here, the maximum values of the volume of the root system, the number of roots, and the average length of the root were obtained. It was revealed that in variants with irrigation, the root system of seedlings spreads in the upper layer (mainly 5-15 cm).