bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinan pengungkapan aset biologis pada perusahaan agrikultur yang terdaftar di BEI
Authors: Fitriasuri Fitriasuri , Putri Melinda Astria
Published: October 2022

This study aims to empirically prove the effect of biological assets intensity, firm size, Ownership Concentration, type of KAP, firm growth, and profitability on the disclosure of biological assets.. This type of research  is quantitative research. The population in this study is all financial data of agricultural companies listed on the IDX in 2019-2021 as many as 26 companies. The sampling technique in this study used a purposive sampling technique for as many as 14 companies. The data analysis technique used descriptive statistical analysis, classical assumption test, multiple linear regression analysis, Coefficient of Determination, Simultaneous Test (F-Test), and Partial Test (T-Test) processed with SPSS 26. The results of this test indicate that the variable biological asset intensity and profitability have a significant positive effect on the disclosure of biological assets, and the type of KAP variable has a significant negative effect on the disclosure of biological assets. While the variables of firm size, ownership concentration, and firm growth do not affect the disclosure of biological assets.
Faktor-Faktor Yang Mempengaruhi Good Governance dengan Sumber Daya Manusia sebagai Variabel Moderasi
Authors: Edinov Sally , Taufik Taufeni , Basri Yesi Mutia , Indrawati Novita , DP Emrinaldi Nur
Published: October 2022

This study aims to find the empirical evidence of the influence about the Government's of Internal Control System, Fixed Assets Administration, Organizational Culture, Organizational Commitment and Information Technology on Good Governance with Human Resources as the moderating variable. This research was conducted in the work unit of Directorate General of Natural Resources and Ecosystem Conservation, the Ministry of Environment and Forestry. The sampling technique used is the census d method by sending a questionnaire to the Nation Civil Apparatus using the application of Financial Accounting System at the agency level. Of the 225 questionnaires distributed, 218 were processed using WarpPLS 7.0 analysis. The results of the study prove that there is an influence of the Government's Internal Control System and Fixed Assets Administration on Good Governance. Meanwhile, Organizational Culture, Organizational Commitment and Information Technology cannot affect Good Governance. Human Resources are only able to moderate the relationship between the Government's Internal Control System and Fixed Assets Administration with Good Governance but are not able to moderate the relationship between Organizational Culture, Organizational Commitment, Information Technology and Good Governance.
Kinerja Keuangan Sebelum dan Masa Pandemi Covid-19 Pada Perusahaan BUMN
Authors: Hasan Amir , Mas Nasharuddin , Sopanah Ana
Published: October 2022

This study aims to determine the impact of the Covid-19 pandemic on the company's financial performance. In this study, the approach used by researchers was quantitative and comparative research. The population of this study is all construction service companies of State-Owned Enterprises listed on the Indonesia Stock Exchange in the period before the Covid-19 pandemic (2018-2019) and during the Covid-19 pandemic (2020-2021), totaling 4 companies. The data source used in this study is secondary data, from annual reports. In this study, the analytical methods used are descriptive quantitative analysis and inferential analysis. Inferential statistical analysis used in this study were paired sample t-test and independent sample t-test. The results of the overall hypothesis test show that there are differences in financial performance between before and during the Covid-19 pandemic, state-owned construction service companies listed on the Indonesia Stock Exchange. Over the past four years, infrastructure development carried out by state-owned construction companies has experienced a good increase. Problems occurred when the spread of the Covid-19 virus began in 2019 which resulted in 2020 infrastructure development being delayed. The delay in the end also affected the financial condition of SOEs. For companies, profits are not only ways and efforts to increase them, but also think about what to do to improve company performance so that they can maintain stability, growth and achievement on profits. The company's performance is related to the company's efforts in managing the resources it has in generating profits that can increase the company's prosperity.
Akuntabilitas Dalam Pandangan Sakai Sambayan
Authors: Purba Sondang Selida Apryastuti , Kristianti Ika , Matitaputty Jean Stevany
Published: October 2022

The determination of the village fund budget that is carried out every year continues to increase and is seen in its management not in line with good village financial management, as evidenced by the discovery of misuse of village funds arising from the lack of accountability in several villages spread across Indonesia. This study aims to see how the role of local wisdom of sakai sambayan in increasing accountability for financial management amidst the diversity of ethnic and religious communities in Rejomulyo Village, Palas sub-district, South Lampung regency. This research is a qualitative research with primary data sources obtained through interviews and documentation with research sources, namely village officials, village consultative bodies, and community leaders in Rejomulyo Village. The research analysis technique used is data reduction, data presentation, and drawing conclusions. The results and discussion in this study indicate that local wisdom of sakai sambayan in Rejomulyo Village can improve the realization of village financial management accountability, this is due to the positive noble values ??of local wisdom of sakai sambayan, namely cooperation, kindness, and upholding the truth that we can live and apply in stages. The stages of village financial management will contain and realize good accountability. The management of village funds in Rejomulyo Village has been carried out in accordance with the applicable rules, namely Permendagri number 20 of 2018 regarding the stages of village financial management including planning, implementation, administration, reporting, and accountability.
Determinan Deteksi Financial Statement Fraud
Authors: Patmawati Patmawati , Rahmawati Meita , Hidayat Muhammad , Damar Sagara Sitepu Christian
Published: October 2022

This study aims to empirically test the determinants of financial statement fraud  detection with the Beneish M-Score, F-Score and Altman Z-Score models. The difference between this study and the previous study is that this study adds the F-Score model variable  which is a financial statement fraud detection model developed using the scaled logistic probability technique. The population of this study is all banks listed on the Indonesia Stock Exchange. The samples in this study were perbankan that met the  purposive sampling criteria. Based on the results of statistical tests obtained from the results of the study, the Beneish M-Score model  has a significant effect on the financial statementt fraud variables, namely the Gross Margin Index (GMI) and the Asset Quality Index (AQI) variable while the Days Sales in Receivables Index (DSRI) variable, Leverage Index (LVGI),  Total Accruals to Total Assets (TATA), and the Sales General and Administrative Expenses Index (SGAI) have no effect on the financial statement fraud variable. The F-Score  variable states that only the Change in cash sales (Ch CS) variable has a significant effect on financial statement fraud while the change in receivable variable (Ch Rev), change in inventories (Ch Inv) and the change in earnings variable (Ch Ear) have a significant effect on the  financial statement fraud variable.  Meanwhile, the Altman Z-Score variable states that the  Z-Score1 variable and the Z-Score3  variable have a significant effect on the financial statement fraud  variable while the  Z-Score2 variable and the Z-Score5  variable have no significant effect.
Idiopathic Peripheral Facial Palsy and Preclampsia: A Case Report
Authors: M Jalal , S Haddout , K Ikouch , O Wajih , A Lamrissi , S Bouhya
Published: October 2022

During pregnancy, pre-eclampsia can be associated to idiopathic peripheral facial nerve palsy. It can be explained by similar physiopathological mechanisms. Facial palsy usually appears during the third trimester of pregnancy or in the early postpartum period. The prognosis is generally good and is not affected by the pregnancy. The occurrence of peripheral facial palsy during pregnancy should alert the obstetrician to look for a possible pre-eclampsia. We report a case of a patient with pre-eclampsia who developed idiopathic peripheral facial palsy during the third semester of pregnancy. Evolution was favorable, following treatment combining anti-hypertensive medication, corticosteroid therapy and ophthalmologic care.
Interest in the Classification of Caesarean Section According to Robson at Teaching Hospital GABRIEL TOURE at Bamako, Mali
Authors: SISSOKO Abdoulaye , TEGUETE Ibrahima , FANE Seydou , BOCOUM Amadou , DJIRE Mohamed Yaya , BAGAYOKO Moussa Arouna , KODIO Amose , DIARRA Siaka , FOMBA Amadou , THERA Tiounkani , TRAORE Youssouf , MOUKORO Niani
Published: October 2022

Caesarean section rates (CSR) are steadily increasing worldwide with levels exceeding the maximum recommended by the WHO. To identify factors that may contribute to the improvement of CSR and to ensure an audit and feedback mechanism, we conducted this study of C-section according to Robson’s classification that identifies 10 mutually exclusive groups based on obstetric characteristics. This was a cross-sectional study from January 1, 2003 to December 31, 2013 on parturients who gave birth in the obstetrics department of the Gabriel TOURE University Teaching Hospital (UTH), which is a 3rd level health structure. We recorded 28,376 deliveries with 9,509 cases of C-section, with a rate of 33.5% (9,509/28,376). Robson's classes 3, 1, 5 and 10 constituted the largest populations and were the greatest contributors to the overall CSR with 7.6%, 7.4%, 5.9% and 5.4% respectively. The emergency admission (evacuation) rate was particularly high among Robson classes 5 and 3 with 57.1% and 46.6% of parturients evacuated, respectively. Classes 1, 3, and 10 had the highest number of cases and indications for emergency C-section. We recorded 298 cases of maternal death or 1.05% (298/28,376) of which 180 or 1.9% (180/9,509) of maternal death related to C-section, it was higher in groups 1, 3 and 10 with respectively 17.8%, 26.6% and 31.6% of cases of death. For fetal prognosis, the overall rate of stillbirth by C-section was 9.2% and was worse in groups 10, 7, 3 and 4 with 23.2%, 10.7%, 9.8% and 9.2% of stillbirths respectively. The stillbirth rate was higher in classes 9 and 10.
Live Delivery in a 46.5-Year-Old Woman in Overt Menopause by Restoring Follicular Sensitivity to Follicle Stimulating Hormone (FSH)
Authors: Check Jerome H. , Check Diane L. , Richardson Kiana
Published: October 2022

For almost 40 years, there have been several publications where ovulation induction has occurred by lowering elevated serum follicle stimulating hormone (FSH) to up-regulate down-regulated FSH receptors on granulosa theca cells thus restoring follicular sensitivity to endogenous gonadotropins resulting in live deliveries. The majority of case reports used ethinyl estradiol to lower FSH. The advantage of ethinyl estradiol is that it does not add to the serum estradiol and thus allows the physician to better determine follicular maturation. To date the oldest woman to have ovulation induction and live delivery despite menopause was aged 45. A 46.5-year-old woman with 9 months of amenorrhea with a serum estradiol <15 pg/mL and a serum FSH of 117 mIU/mL was given ethinyl estradiol 20 micrograms daily. She attained a mature follicle on day 44 and conceived with natural intercourse with vaginal progesterone supplementation in the luteal phase. She delivered a full-term healthy chromosomally normal baby. Interestingly, she also had a successful live delivery when we treated her with progesterone in the luteal phase at age 42 when her day 3 serum FSH was 47 mIU/mL. Besides a luteal phase defect, she failed to release the egg from the follicle first naturally then with 10,000 units of human chorionic gonadotropin (hCG) but finally did release and conceived with the novel use of granulocyte colony stimulating factor, which was used again at age 46.5. Live deliveries are uncommon in women aged 46 even with regular menses and normal egg reserve. Precedents are important in medicine. Thus, this case represents the oldest woman with documented menopause to conceive naturally.
Psychological and Social Effects of Infertility on Women: A Mixed Method Research
Authors: Olowokere Adekemi E. , Olowookere Jane O. , Komolafe Abiola O. , Oyelade Oyeyemi O. , Olajubu Aanuoluwapo O. , Aladegboye Mercy K.
Published: October 2022

Background: Infertility is one of the most devastating experiences among infertile women in Nigeria. This is due to the socio-cultural significance attached to childbearing in Nigerian society. This study was conducted to assess and explore the psychological and social effects of infertility, identify the support system and coping strategies available to and utilized by infertile women selected from Gynecological Clinic of Owo Federal Medical Centre. Methods: The current research was a cross-sectional study and it used a convergent mixed method approach to collect data from September, 2017 to January, 2018. Structured questionnaire and in-depth interview guide were used to collect data from 152 and 10 infertile women who were selected by purposive sampling. Quantitative data were analyzed using descriptive statistics and multinomial logistics regression in SPSS20 at 0.05 level of significance. The interviews were analyzed via content analysis. Results: The most prevalent psychological and social effects of infertility experienced by the women were frustration with the different treatment procedures (79.6%) and having sex for purpose of procreation only (78.9%). Higher age (OR = 2.95, CI = 1.68 - 5.29, P=0.01), monogamous family (OR = 6.70, CI = 1.68 - 26.74, P = 0.01) and parity (OR = 4.21, CI = 0.42 - 41.76, P=0.03) significantly influenced psychological effects of infertility while zero parity (OR =1.34, CI = 0.89 - 4.56, P = 0.01) was the only factor that significantly determine the social effects of infertility. The qualitative results show that the women experienced a range of psychological and social issues ranging from grief to negative self-concept, inordinate desire for sexual intercourse, societal stigma, social withdrawal and isolation. Conclusion: The study concluded that infertile women experience a range of psychological and social issues. The findings from both the quantitative and qualitative assessment indicated the need to provide more psychosocial support for women with infertility.
The Rare Association of Ectopic Pregnancy and Hydatidiform Mole: A Case Report
Authors: Alexandre Bobbio dos SANTOS , Barbara Gobetti PANCIERI , Camila Correia RIOS , Leticia Lanna de BRITO E SILVA , Rubens Bermudes MUSIELLO , Antonio CHAMBO FILHO
Published: October 2022

An ectopic molar pregnancy is a rare event, occurring in 1 in every 20,000–100,000 pregnancies. The condition may present as a complete or partial molar pregnancy and the ectopic site can vary as in a non-molar ectopic pregnancy. When a molar pregnancy presents as a tubal ectopic pregnancy, the risks related to both conditions, including tubal rupture and progress to malignancy, are compounded. The definitive diagnosis is normally reached by histopathology of the surgical specimen, since imaging tests are usually unable to differentiate between a molar and a non-molar ectopic pregnancy. While the specific histological findings may confirm the diagnosis of hydatidiform mole, immunohistochemistry is essential to differentiate between a complete and a partial molar pregnancy. Although in the majority of cases surgical resection is considered the definitive treatment, it is estimated that 20% of patients with a molar pregnancy may develop gestational trophoblastic neoplasia, hence requiring a risk-specific follow-up. This report describes a case of a tubal molar pregnancy and includes a review of clinical, diagnostic and therapeutic aspects, as well as a discussion on the particularities of this rare association.
Challenges in Allergy Diagnostics and Solutions Worth Considering
Authors: Kos Snjezana , Sanders Robert-Jan
Published: October 2022

The introduction of molecular components has led to exponential growth in the field of allergy diagnosis over the last two decades and allergy testing is now more complex and comprehensive. Most specialists who do not deal with the management of allergy patients on a daily basis may find it difficult to stay up-to-date with current developments in the field, which, in practice, may lead to unnecessary or nontargeted testing. The primary objective of this review is to briefly summarise the major differences in past immunoglobulin E testing compared to modern methods. The secondary objective is to give an overview of approaches that are, in the authors’ opinions, worth considering as concepts because they address two fundamental issues in allergy management: how to relate results of immunoglobulin E testing to severity of symptoms, and how to increase the pretest probability of an allergy and facilitate management of an allergic patient.
Raising the Clinical Bar Beyond Current Biologics in Uncontrolled Persistent Asthma: Translating Emerging Data in Future Clinical Decisions
Authors: Stutfield Sarah
Published: October 2022

Asthma is a heterogeneous disease with multiple phenotypes, caused by a complex interplay of inflammatory pathways. Up to 70% of patients with asthma have Type 2 inflammation, characterised by the presence of interleukin (IL)-4, IL-5, and IL-13. Uncontrolled persistent asthma represents a considerable disease burden associated with a higher rate of exacerbations, more frequent hospitalisations, greater oral corticosteroid (OCS) use, more impaired lung function, reduced health-related quality of life (QoL), and Type 2 inflammatory comorbidities versus controlled asthma. There remains an unmet need for new therapies for patients with uncontrolled persistent asthma. Several agents targeting mediators of Type 2 inflammation are in clinical development for severe asthma, including prostaglandin D2 receptor 2 (DP2)/chemoattractant receptor-homologous molecule expressed on Th2 (CRTh2) antagonists and monoclonal antibodies (mAb) that specifically bind IL-33, IL-25, thymic stromal lymphopoietin (TSLP), and IL-4 receptor (IL-4Rα). Dupilumab blocks signalling of IL-4 and IL-13 and is under investigation in various diseases driven by Type 2 inflammation. In Phase III clinical trials in patients with uncontrolled, persistent asthma, dupilumab was well tolerated and demonstrated significant efficacy versus placebo in reducing the rate of asthma exacerbations, and improving lung function, asthma symptoms, and QoL. This article summarises the proceedings of a symposium held at the European Academy of Allergy and Clinical Immunology (EAACI) 2018 Congress, which brought together an international faculty of experts to explore current understandings of asthma pathophysiology, with particular focus on Type 2 inflammatory pathways, and to provide an overview of current therapies, unmet medical needs, and the potential role of emerging biologics in the treatment of uncontrolled persistent asthma.
Allergy to Stinging Insects: Diagnosis and Management
Authors: Perkins Jessica B. , Yates Anne B.
Published: October 2022

Stinging insects that cause allergic reactions belong to the order Hymenoptera, which includes wasps, hornets, bees, yellow jackets, true hornets, and stinging ants. Individuals stung by these insects can have different clinical outcomes, from common local reactions to severe systemic reactions. Anaphylaxis as a result of insect stings can result in death; therefore, individuals with a history of systemic reaction to stings should be further evaluated and treated. A history of systemic reaction to insect stings and immunoglobulin E sensitivity to specific insect venoms, determined by blood or skin testing, are criteria for venom immunotherapy administration. Venom immunotherapy modulates the immune system to make the recipient less sensitive to venom and can be curative. All individuals with a history of systemic reaction to insect stings should be provided with an adrenaline auto-injector and educated in avoidance measures to prevent future stings. This review will discuss the diagnosis of venom allergy, the management of venom allergic individuals with venom immunotherapy, and identification of risk factors for severe anaphylaxis to insect stings. This review will also aid clinicians in discussing avoidance measures with patients.
Towards Optimised Management of Cow’s Milk Protein Allergy
Authors: Pedder Amanda
Published: October 2022

This symposium took place during the 2018 meeting of the European Academy of Allergy and Clinical Immunology (EAACI). Focussing on the fundamental issues of suboptimal management of patients with cow’s milk protein allergy (CMPA), the speakers discussed key themes for optimising management. Prof Madrazo-de la Garza evaluated the challenges of diagnosis and management of CMPA in infants. Nonspecific symptoms, indicative of other conditions, mean that CPMA is often misdiagnosed as lactose intolerance, a rare condition in infants. Increased awareness of CMPA symptoms and a clear distinction from lactose intolerance may facilitate earlier, accurate diagnosis and implementation of appropriate dietary interventions. Dr Nutten followed by exploring variability in the composition of commercialised extensively hydrolysed formulas (eHF) intended for the management of CMPA and the associated potential clinical impact. Large variations in peptide profiles and residual allergenicity reflect a lack of definition for eHF composition. Although the clinical trials required to confirm the efficacy of eHF by demonstrating tolerance in >90% of infants with CMPA are performed, composition analyses for characterisation, quality control, and reproducibility are crucial for ensuring safe and suitable products throughout the product lifecycle. Prof O’Mahony concluded the meeting by focussing on the importance of the gut microbiome in food allergy. The establishment of a stable gut microbial community closely tracks host growth and immune development. Delayed or altered establishment leads to microbiome immaturity, which has been associated with an increased risk of food allergies. Nutritional strategies, such as the use of eHF containing lactose, to support microbiome development complement existing CMPA treatment.
What Is the Role of the Environment (Exposome) in Inflammatory Bowel Disease?
Authors: Zennaro Carlotta
Published: October 2022

OPENING Day 2 of the 17th Congress of European Crohn’s and Colitis Organisation (ECCO), James Lindsay, Professor of Inflammatory Bowel Disease, Barts Health NHS Trust, London, UK, and The London School of Medicine, Queen Mary University of London, UK, discussed the influence of the environment on the risk of developing inflammatory bowel disease (IBD). The presentation discussed the pathways that mediate environmental impact on IBD as well as the limitations of presently available research, giving a valuable insight into what future studies could be conducted to ultimately determine the role of environmental factors in IBD.

The present understanding of IBD, an inflammatory disease, which includes Crohn’s disease (CD) and ulcerative colitis (UC), is that the condition arises from an immune response to micro-organisms of the intestinal flora in genetically susceptible individuals. In addition to disease pathogenesis, other important aspects such as progression, extraintestinal manifestations, and immunogenicity to therapies, are yet to be well understood. While the genetics base is clear, it does not account for the discordance of disease in monozygotic twins, the increased incidence in second generation immigrants, or the rapid increase in IBD cases in the last 50 years. In light of these observations, Lindsay expressed the importance of examining the role of the environment, which, he stressed, does not comprise a single factor, but a multitude of factors that are likely to impact disease onset and natural history.
Predicting the ignition sequences in a separated stratified swirling spray flame with stochastic flame particle tracking
Authors: Xie Qing , Yang Siheng , Cheng Hao , Zhang Chi , Ren Zhuyin
Published: October 2022

Stochastic flame particle tracking in conjunction with non-reacting combustor simulations can offer insights into the ignition processes and facilitate the combustor optimization. In this study, this approach is employed to simulate the ignition sequences in a separated dual-swirl spray flame, in which the newly proposed pairwise mixing-reaction model is used to account for the mass and energy transfer between the flame particle and the surrounding shell layer. Based on the flame particle temperature, the particle state can be classified in to burnt, hot gas, and extinguished. The additional state of hot gas is introduced to allow the flame particles with high temperature to survive from nonflammable region and then potentially to ignite the nearby favourable regions. The simulations of the separated stratified swirl spray flame reveal two different ignition pathways for flame stabilization. The first showed that some flame particles from the spark would directly enter the main recirculation zone resulting from the velocity randomness and then ignite both sides of the combustor simultaneously. The second showed that flame particles from the spark would ignite the traversed regions following the swirl motion inside the combustor. The predicted ignition sequences were compared with the evolution of flame morphology recorded by high-speed imaging from experiments, showing qualitative agreement.
GAMBARAN KESIAPAN IBU HAMIL TRIMESTER III DALAM MENGHADAPI PERSALINAN DI MASA PANDEMI COVID-19
Authors: Anita Yuliani Anita
Published: October 2022

Pandemi Covid-19 berdampak pada banyak sektor termasuk pelayanan kesehatanmaternal. Banyak keterbatasan pada bidang maternal, seperti keengganan ibu hamilmelakukan pemeriksaan ke fasilitas kesehatan karena takut tertular, ketidaksiapanlayanan dari fasilitas kesehatan, banyaknya informasi bohong yang tidak sesuai mengenaiCovid-19, dan khawatir akan kesiapan tempat persalinan yang ada. Ibu hamil yangdisertai komorbid mempunyai dampak yang lebih berat untuk penyakitnya sehinggalebih riskan terhadap proses persalinannya. Pemeriksaan kehamilan dan persiapanpersalinan yang baik, sangat penting dilakukan agar keadaan ibu dan janin sehat. Fasilitaskesehatan terstandar sudah menerapkan protokol Covid-19 dengan baik, tetapi belumcukup data yang dapat menggambarkan bagaimana kesiapan ibu hamil untuk melakukanpersalinan di fasilitas kesehatan ini. Penelitian ini bertujuan untuk melihat gambarankesiapan persalinan di masa pandemi pada ibu hamil trimester-III dengan jenis penelitiandeskriptif. Sampelnya adalah ibu hamil trimester III sejumlah 75 orang. Lokasi penelitiandi Klinik Utama Barokah Kota Bandung. Hasil penelitian ini menunjukan sebagian besarresponden pada aspek fisik dalam kategori siap yaitu sebanyak 71 orang (94,67%).Sebagian besar responden pada aspek psikologis dalam kategori siap yaitu sebanyak70 orang (93,33%). Seluruh responden pada aspek finansial dalam kategori siap yaitusebanyak 75 orang (100%) serta sebagian besar responden pada aspek kultural dalamkategori siap yaitu sebanyak 69 orang (92 %). Simpulan penelitian ini adalah bahwasebagian besar responden memiliki kesiapan yang tinggi dalam menghadapi persalinan dimasa pandemi Covid-19 terutama aspek fisik, psikologis, finansial dan kultural. Kesiapanyang paling dominan ada pada aspek finansial.
PENGALAMAN IBU YANG MELAHIRKAN DENGAN ASUHAN KEBIDANAN KOMPLEMENTER TAHUN 2021
Authors: Puspitasari Nike Arta , Hukmilah Himayatul
Published: October 2022

Nyeri persalinan kala I merupakan pengalaman yang menimbulkan perasaan khawatirdan takut sehingga dapat memperberat rasa nyeri persalinan. Rasa cemas dan takut dapatmeningkatkan aktivitas sistem saraf simpatis, serta meningkatkan sekresi katekolamin,sehingga proses persalinan menjadi lebih lama Berbagai upaya dilakukan untukmengatasi nyeri persalinan, salah satunya penatalaksanaan nonfarmakologi seperti asuhankebidanan komplementer. Penelitian tentang pengalaman ibu yang melahirkan denganasuhan kebidanan komplementer belum banyak dilakukan. Penelitian ini bertujuan untukmenemukan makna atau arti melahirkan dalam konteks asuhan kebidanan komplementer.Jenis penelitian ini adalah kualitatif dengan pendekatan fenomenologi. Teknik sampelyang digunakan pada penelitian ini adalah purposive sampling. Wawancara dilakukan diklinik dan tempat tinggal Informan dengan menggunakan pedoman wawancara mendalam.Analisis hasil wawancara menggunakan analisis menurut Miles dan Huberman. Hasilpenelitian didapatkan bahwa 1) Alasan ibu melahirkan di klinik Bumi Sehat Bahagia (BSB)terdiri dari kualitas pelayanan, sumber informasi, pengalaman, dan jarak 2) Pengalamanibu melahirkan dengan asuhan kebidanan komplementer terdiri dari kontraksi semakinkuat, nyaman, tenang, lebih bertenaga, durasi persalinan lebih singkat, intensitas nyeriberkurang. Asuhan kebidanan komplementer yang diberikan terdiri dari pijat endorphin,pijat oksitosin, pemberian buah kurma, terapi birth ball, pemberian aromaterapi, terapimurottal Al-Qur’an 3) Makna bersalin dengan asuhan kebidanan komplementer terdiridari merasa diperhatikan, peran bidan yang maksimal, minim trauma, lebih bertenaga, dandurasi persalinan lebih singkat
EFEKTIFITAS TERAPI KOMPLEMENTER : TUINA AKUPOIN DAN FACIAL LOVING TOUCH DALAM MENINGKATKAN PRODUKSI ASI
Authors: Miraturrofi’ah Mira
Published: October 2022

Latar Belakang : Air Susu Ibu (ASI) adalah sumber gizi dan makanan paling aman serta ideal bagi bayi usia 0-6 bulan. ASI mengandung hampir 200 unsur zat makanan. WHO merekomendasikan pemberian ASI selama minimal 6 bulan. UNICEF memastikan bahwa bayi yang diberi susu formula memiliki kemungkinan meninggal pada bulan pertama sebesar 25 kali lebih besar dibandingkan bayi yang diberi ASI eksklusif. Dalam pelaksanaannya pemberian ASI eksklusif tidak selalu lancar. Penelitian di Australia mengemukakan bahwa 29% ibu nifas berhenti memberikan ASI akibat produksi ASI menurun. Penurunan ASI pada hari-hari pertama setelah melahirkan dapat disebabkan kurangnya stimulasi hormon prolaktin dan oksitosin yang berperan penting dalam kelancaran produksi ASI.

Tujuan penelitian ini adalah membandingkan terapi komplementer Tuina Akupoin dan Facial Loving Touch (FLT) dalam meningkatkan produksi ASI.

Metode : Penelitian comparative design dengan rancangan two group pretest and posttest design. Pretest dilakukan melalui pengukuran produksi ASI dengan pumping elektrik selama 5 menit. Kemudian dilakukan intervensi. Grup I diberikan intervensi Tuina Akupoint, sementara Grup II diberikan intervensi FLT. Lama intervensi setiap kelompok 20 menit. Pengelompokan didasarkan pada responden mana memenuhi kriteria inklusi terlebih dahulu. Posttest dilakukan dengan mengukur produksi ASI selama 5 menit.

Hasil : Kedua intervensi efektif meningkatkan produksi ASI (p-value Grup I = 0.000 < 0.05 & Grup II = 0.000 < 0.05), namun kelompok intervensi Tuina Akupoint memiliki nilai rata-rata produksi ASI lebih besar yaitu 8.0 dibandingkan kelompok intervensi FLT 4.05.

Simpulan : Terapi komplementer Tuina Akupoint dapat dijadikan salah satu alternativ dalam meningkatkan produksi ASI.
SKRINING PERKEMBANGAN ANAK USIA 5 – 6 TAHUN DENGAN KUESIONER PRA SKRINING PERKEMBANGAN (KPSP)
Authors: Barbara Maria A.D
Published: October 2022

Perkembangan anak merupakan sebuah proses kontinu yang terjadi sejak masa konsepsi hingga dewasa. Berdasarkan studi pendahuluan yang dilakukan di RA ( Raudhatul athfal ) Ath-Thohiriyah terdapat 7 dari 10 orang anak yang masih belum bisa menggambar orang dengan minimal memuat 6 bagian tubuh, menyebutkan jenis-jenis warna, mengetahui fungsi benda, dan masih belum mengenali beberapa kata sifat benda. Menurut Kepala Sekolah RA Ath-Thohiriyah, diketahui bahwa di RA tersebut belum pernah dilakukan test deteksi dini tumbuh kembang. Penelitian ini bertujuan untuk mengetahui bagaimana perkembangan anak usia 5 – 6 tahun di RA Ath-Thohiriyah Cililin Tahun 2021. Rancangan penelitian ini menggunakan metode deskriptif. Sampel yang digunakan yaitu anak usia 5 – 6 tahun di RA Ath-Thohiriyah Cililin beserta ibu/pengasuhnya sebanyak 41 orang. Pengambilan sampel dalam penelitian ini menggunakan total sampling. Data yang digunakan yaitu data primer dengan menggunakan KPSP. Analisis data menggunakan univariat dalam bentuk presentase. Kategori perkembangan sesuai sebanyak (32%), kategori perkembangan meragukan sebanyak (36%), dan kategori perkembangan penyimpangan sebanyak (32%). Hampir setengahnya responden berada dalam kategori perkembangan meragukan.
FACTORS RELATED TO HEPATITIS B IN PREGNANT WOMEN
Authors: Surya Atmaja Rani Widiyanti
Published: October 2022

The prevalence of hepatitis is 0.4% of the population in Indonesia, of which 1-5% are pregnant women with hepatitis B virus. The purpose of this study was to determine the relationship between maternal characteristics, knowledge of hepatitis B, prevention attitudes, family history, immunization history, sexual activity, traditional medicine and rest with the incidence of Hepatitis B in Cirebon Regency in 2020. Analytical study with a case-control approach with Chi-square test and logistic regression. The number of samples using the Stanley Lemeshow formula obtained 42 people, taken by purposive sampling at the Waruroyom and Mundu Health Centers. Family history of hepatitis was only found in pregnant women with hepatitis B, namely 2 people (21.4%) with a p value of 0.32 and an OR value of 3.545 with a confidence interval between 2.149 to 5.850. The majority of pregnant women with hepatitis B did rest 6 hours/day that is 10 people (71.4%) while those who do not have hepatitis B majority do rest <6 hours/day that is 20 people (71.4%) with p value 0.021 and OR value 0.160 with a confidence interval of 0.039 to with 0.662. Variables related to the incidence of Hepatitis B in pregnant women are education, traditional medicine and rest. The greatest and smallest relationship strengths were education (OR:154,324) and rest (OR:18,932). Pregnant women with low education need to be given information or health education about hepatitis.
PENGEMBANGAN MEDIA VIDEO DAN KOMIK PENDIDIKAN KESEHATAN REPRODUKSI TENTANG BAHAYA PERNIKAHAN DINI BAGI SISWA/I SMP TAHUN 2020
Authors: Diyah Diyah Sri Yuhandini , Jubaedah Entin , Sriyatin Sriyatin
Published: October 2022

Kurangnya pengetahuan remaja mengenai pernikahan dini memberikan risiko 2,3 kali lebih besaruntuk melakukan pernikahan dini. Promosi kesehatan berupa video dan komik merupakan salahsatu sarana yang dapat menampilkan informasi kesehatan kepada remaja sehingga meningkatkanpengetahuan yang diharapkan dapat merubah perilaku yang mendukung kesehatan. Penelitianini bertujuan untuk melakukan pengembangan media video dan komik pendidikan kesehatanreproduksi tentang bahaya pernikahan dini bagi siswa/i SMP di Kota Cirebon. Metode penelitianadalah metode penelitian pengembangan (RnD). Prosedur penelitian yang dilakukan dalampenelitian ini 1) potensi dan masalah, 2) pengumpulan data, 3) desain produk, 4) validasi desain,5) revisi desain, 6) uji coba produk, 7) revisi produk, 8) uji coba pemakaian, 9) revisi produk,10) produksi masal. Hasil Uji Validasi Desain dari ahli materi video sebesar 93,8%, 97,7%, dan100% dan dari ahli materi komik sebesar 100%, 95%, dan 98% dan dari ahli media video sebesar100% dan komik sebesar 100%. Tahap uji coba produk pada lapangan utama (kelompok terbatas)dengan subyek 13 siswa, untuk video dengan hasil sebesar 92,90% dan untuk komik sebesar95,5% (sangat baik). Dengan demikian hasil temuan video dan komik edukatif tentang bahayapernikahan dini dikategorikan layak untuk dilanjutkan pada uji coba pemakaian pada kelompokyang lebih luas.
ASPEK RELIGIUSITAS DAN PSIKOSOSIAL PASIEN LUKA KAKI DIABETIK TIPE MIXULCER GRADE 4
Authors: Syabariyah Sitti , Nisa Afdhalun , Anggraeni Wini , Kadriatun Tutur
Published: October 2022

Gangguan ulkus kaki pada penderita diabetes ini menciptakan masalah sosial yang kompleks karenabeban keuangan yang ditimbulkan dari tingginya biaya pengobatan dan penyembuhan. Selainberat, morbiditas kaki diabetik menyebabkan lama hari perawatan di rumah sakit berkepanjangan,timbulnya masalah psikososial dan sosial baik bagi pasien maupun keluarganya. Penelitianini bertujuan untuk menggali pengalaman pasien ulkus kaki diabetic tentang aspek religiusitasdan psikososial setelah diberikan perawatan luka dengan terapi adjuvant vibrasi dan murotalquranic. Penelitian ini menggunakan metode penelitian kualitatif case study dengan pendekatanfenomenologi. Sampel dipilih dengan purposive sampling. Data wawancara dianalisis denganmenggunakan Collaizi. Hasil didapatkan dengan wawancara mendalam terhadap 1 kasus kelolaan(case study pasien perempuan, usia 65 tahun dengan lama perawatan 12 minggu. Hasil penelitiandidapatkan 2 tema (religiusitas dan psikososial) terdiri dari 5 sub tema religiusitas dan yaitu1) keyakinan, 2) praktek agama, 3) penjiwaan,4) pengetahuan agama dan 5) konsekuensi. Temapsikososial terdiri 1) perubahan yang dirasakan pasien; 2) cara mengatasi perubahan psikososialpasien; 3) faktor pendukung dan penghambat dalam mengatasi perubahan psikososial pasien; 4)harapan pasien dalam mengatasi perubahan psikososial. Kemampuan perawat dalam menggaliaspek religiusitas dan psikososial pasien perlu dilakukan selama perawatan untuk meningkatkanmotivasi dan percepatan penyembukan luka pasien.
HUBUNGAN TEKANAN DARAH DENGAN KEJADIAN STROKE DI UNIT GAWAT DARURAT
Authors: Dabalok Ristonilassius , Murtiningsih  , Iin Inayah
Published: October 2022

Stroke merupakan suatu gangguan pada pembuluh darah otak, yang menjadi penyebabutama kematian dan kecacatan di seluruh dunia. Kondisi tekanan darah yang meningkatdalam waktu yang lama memicu terjadinya kerusakan lapisan pembuluh darah menjaditidak elastis. Penelitian ini bertujuan untuk mengetahui adanya hubungan antara tekanandarah systole dan diastole terhadap kejadian stroke pada pasien yang masuk di unitgawat darurat Rumah Sakit A. Bandung. Penelitian ini menggunakan metode deskriptifkuantitatif dengan pendekatan cross-sectional pada 65 responden yang berusia 17 hinga65 tahun, dengan analisa data menggunakan uji korelasi spearman rho. Hasil penelitianmenunjukkan bahwa ada hubungan yang signifikan antara tekanan darah systole dengankejadian hipertensi dengan p-value 0,020, dan adanya hubungan yang signifikan antaratekanan darah diastolee dengan kejadian stroke dengan p-value 0,015. Simpulan yangdapat ditarik adalah tekanan darah tinggi berkontribusi sebagai penyebab kejadian stroke.Peneliti menyarankan agar pasien hipertensi melakukan daya dan upaya mengkontroltekanan agar terhindar dari penyakit stroke.
PERAN KELUARGA DALAM MERAWAT ANGGOTA KELUARGA YANG MENDERITA TB PARU DI RUANGAN SANTO IGNATIUS RUMAH SAKIT SANTA ELISABETH MEDAN
Authors: Situmorang Teresia , Derang Imelda , Sirait Imelda , Simorangkir Lindawati
Published: October 2022

Tuberkulosis paru adalah penyakit yang dapat ditularkan langsung melalui kuman TB (Mycobacterium tuberculosis), dan  menjadi krisis di seluruh dunia sehingga dilakukanlah suatu program pengendalian yang disponsori Nasional (RNTCP). Hal  ini yang paling berperan  adalah keluarga, berupa dukungan fisik dan fsikologis  dalam merawat anggota keluarga. Penelitian ini bertujuan guna mengulas lebih jauh peran keluarga dalam merawat anggota keluarga yang sedang menderita penyakit TB paru. Adapun metodologi penelitian yang akan digunakan dalam penelitian ini adalah dengan menggunakan metode kualitatif fenomenologis, yang mana dalam penelitian ini pula terdiri dari 6 orang informan yang berasal dari keluarga inti dengan ketentuan terdapat anggota keluarga yang menderita TB paru tersebut. Dari hasil  penelitian diperoleh 6 thema yaitu 1) Pengetahuan keluarga, tingkat keseriusan, dan penularan, 2) Hambatan keluarga, 3) Keyakinan keluarga, 4) Dukungan keluarga dan Kesehatan setempat 5) Pendampingan, pemenuhan nutrisi, dan pengawasan 6) Pemahaman keluarga mengenai  lingkungan sehat. Hal ini diakibatkan karena keluarga belum memahami penularan dai TB paru, kurang ekonomi, waktu dan pengetahuan, kurangkanya informasi selama proses pengobatan, kurangnya pengawasan dalam pemberian obat dan gizi, serta keluarga tidak menyadari akan pentingnya lingkungan sehat. Berdasarkan hasil yang telah diperoleh tersebut, dapat disimpulkan bahwa kurangnya peran keluarga dalam merawat anggota keluarga yang menderita TB paru. Dari hasil tersebut dapat disimpulkan bahwa peran keluarga dalam merawat anggota keluarga TB paru kurang. Sehingga diharapkan lebih meningkatkan adanya pendampingan keluarga bagi anggota keluarga yang TB paru seperti memperhatikan gizi, mengawasi untuk minum obat, mengingatkan istirahat, menanyakan keluhan, menemani kontrol ke Puskesmas atau Rumah sakit agar tidak putus obat, serta memperhatikan lingkungan bersih dan sehat.
ANALISIS BIAS KOGNITIF MASYARAKAT TERHADAP INFORMASI HOAKS TENTANG COVID-19
Authors: Tarwati Kartika , Danismaya Irawan , Safariyah Erna
Published: October 2022

Informasi yang diterima oleh masyarakat selama masa pandemi COVID-19 tidak selalubenar. Salah satu bentuk yang muncul pada saat menerima berita hoax adalah biaskognitif. Bias kognitif dipengaruhi oleh memori seseorang. Sehingga keputusan ataurespon yang diberikan banyak bergantung pada pengetahuan, emosi, dan pengalaman.Terdapat lima jenis bias kognitif yang dibahas pada penelitian ini. Tujuan dari penelitianini adalah untuk menganalisis jenis bias kognitif yang muncul pada masyarakat saatmenerima informasi hoax mengenai COVID-19. Metode yang digunakan pada penelitianini adalah deskripsi analisis. Tempat yang dipilih untuk dilakukannya penelitian ini adalahKecamatan Lembursitu di Kota Sukabumi. Pada saat penelitian ini dilakukan, KotaSukabumi sedang berada pada PPKM Level 4. Terdapat 396 responden yang telah dipilihmenggunakan purposive sampling untuk menjawab 20 pertanyaan yang telah diberikandalam bentuk google form. Hasil yang diperoleh adalah ada lima bias kognitif yangmuncul. kelima jenis bias kognitif tersebut adalah neglecting probability, social proof,Dunning-Kruger bias,confirmation bias dan bandwagon effect. Kelimanya muncul padaresponden dengan rentang usia 10-59 tahun. Sementara itu, hanya neglecting probabilitydan bandwagon effect yang muncul pada masyarakat dengan rentang usia 60-69. Kondisitersebut dapat dipengaruhi oleh tingkat literasi dari masyarakat Lembursitu yang masihperlu ditingkatkan lagi dan juga penggunaan dari sosial media yang aktif. Oleh karenaitu, Pemerintah Kota Sukabumi dengan terus memberikan informasi terbaru dan akuratmelalui sumber informasi yang mudah diakses masyarakat dan penguatan dibidangliterasi bagi masyarakat
Engineering elastic bioactive composite hydrogels for promoting osteogenic differentiation of embryonic mesenchymal stem cells
Authors: Wang Min , Guo Yi , Deng Zexing , Xu Peng
Published: October 2022

The development of bioactive materials with good mechanical properties and promotion of stem cell osteogenic differentiation has important application prospects in bone tissue engineering. In this paper, we designed a novel organic‒inorganic composite hydrogel (FPIGP@BGN-Sr) utilizing diacrylated F127 (DA-PF127), β-glycerophosphate-modified polyitaconate (PIGP) and strontium-doped bioactive glass nanoparticles (BGN-Sr) through free radical polymerization and coordination interactions and then evaluated its promoting effect on the osteogenic differentiation of mouse embryonic mesenchymal stem cells in detail. The results showed that the FPIGP@BGN-Sr hydrogel exhibited a controlled storage modulus by changing the amount of BGN-Sr. Notably, the FPIGP@BGN-Sr hydrogel possessed excellent elastic ability with a compressive strain of up to 98.6% and negligible change in mechanical properties after 10 cycles of compression. In addition, the FPIGP@BGN-Sr hydrogel had good cytocompatibility, maintained the activity and proliferation of mouse embryonic mesenchymal stem cells (C3H10T1/2), and effectively enhanced the activity of alkaline phosphatase, osteogenic gene expression and biomineralization ability of the cells. In conclusion, the excellent mechanical properties and osteogenic biological activity of the FPIGP@BGN-Sr hydrogel make it a promising organic‒inorganic composite bioactive material for stem cell-based bone regeneration.
Recent advances in bacteria-mediated cancer therapy
Authors: Liang Shuya , Wang Chao , Shao Yingchun , Wang Yanhong , Xing Dongming , Geng Zhongmin
Published: October 2022

Cancer is among the leading cause of deaths worldwide. Although conventional therapies have been applied in the fight against the cancer, the poor oxygen, low extracellular pH, and high interstitial fluid pressure of the tumor microenvironment mean that these treatments fail to completely eradicate cancer cells. Recently, bacteria have increasingly been considered to be a promising platform for cancer therapy thanks to their many unique properties, such as specific tumor-targeting ability, high motility, immunogenicity, and their use as gene or drug carriers. Several types of bacteria have already been used for solid and metastatic tumor therapies, with promising results. With the development of synthetic biology, engineered bacteria have been endowed with the controllable expression of therapeutic proteins. Meanwhile, nanomaterials have been widely used to modify bacteria for targeted drug delivery, photothermal therapy, magnetothermal therapy, and photodynamic therapy, while promoting the antitumor efficiency of synergistic cancer therapies. This review will provide a brief introduction to the foundation of bacterial biotherapy. We begin by summarizing the recent advances in the use of many different types of bacteria in multiple targeted tumor therapies. We will then discuss the future prospects of bacteria-mediated cancer therapies.
The uniformity and stability of cellular mass density in mammalian cell culture
Authors: Liu Xili , Oh Seungeun , Kirschner Marc W.
Published: October 2022

Cell dry mass is principally determined by the sum of biosynthesis and degradation. Measurable change in dry mass occurs on a time scale of hours. By contrast, cell volume can change in minutes by altering the osmotic conditions. How changes in dry mass and volume are coupled is a fundamental question in cell size control. If cell volume were proportional to cell dry mass during growth, the cell would always maintain the same cellular mass density, defined as cell dry mass dividing by cell volume. The accuracy and stability against perturbation of this proportionality has never been stringently tested. Normalized Raman Imaging (NoRI), can measure both protein and lipid dry mass density directly. Using this new technique, we have been able to investigate the stability of mass density in response to pharmaceutical and physiological perturbations in three cultured mammalian cell lines. We find a remarkably narrow mass density distribution within cells, that is, significantly tighter than the variability of mass or volume distribution. The measured mass density is independent of the cell cycle. We find that mass density can be modulated directly by extracellular osmolytes or by disruptions of the cytoskeleton. Yet, mass density is surprisingly resistant to pharmacological perturbations of protein synthesis or protein degradation, suggesting there must be some form of feedback control to maintain the homeostasis of mass density when mass is altered. By contrast, physiological perturbations such as starvation or senescence induce significant shifts in mass density. We have begun to shed light on how and why cell mass density remains fixed against some perturbations and yet is sensitive during transitions in physiological state.