bluuebunny/crossref_metadata_2025 huggingface dataset:
Duty-Cycle-Based Pre-Emption Protocol for Emergency Networks
Authors: Kim Gayoung , Rim Minjoong
Published: December 2021

This paper proposes a new duty-cycle-based protocol for transmitting emergent data with high priority and low latency in a sensor network environment. To reduce power consumption, the duty cycle protocol is divided into a listen section and a sleep section, and data can only be received when the receiving node is in the listen section. In this paper, high-priority transmission preempts low-priority transmission by distinguishing between high-priority preamble and low-priority preamble. However, even when a high priority transmission preempts a low priority transmission such that the high priority transmission is received first, if the sleep period is very long, the delay may be large. To solve this problem, the high priority short preamble and high priority data reduce receiver sensitivity and increase coverage through repeated transmission. If there are several receiving nodes within a wide coverage, the receiving node that wakes up first can receive the transmission, thus reducing the delay. The delay can also be further reduced by alternately reducing the sleep cycle of one node among the receiving nodes that can receive it. This paper shows that emergent data can be transmitted effectively and reliably by reducing the delay of high-priority data to a minimum through the use of preemption, coverage extension, and an asymmetric sleep cycle.
A Comparison of Three Airborne Laser Scanner Types for Species Identification of Individual Trees
Authors: Prieur Jean-François , St-Onge Benoît , Fournier Richard A. , Woods Murray E. , Rana Parvez , Kneeshaw Daniel
Published: December 2021

Species identification is a critical factor for obtaining accurate forest inventories. This paper compares the same method of tree species identification (at the individual crown level) across three different types of airborne laser scanning systems (ALS): two linear lidar systems (monospectral and multispectral) and one single-photon lidar (SPL) system to ascertain whether current individual tree crown (ITC) species classification methods are applicable across all sensors. SPL is a new type of sensor that promises comparable point densities from higher flight altitudes, thereby increasing lidar coverage. Initial results indicate that the methods are indeed applicable across all of the three sensor types with broadly similar overall accuracies (Hardwood/Softwood, 83–90%; 12 species, 46–54%; 4 species, 68–79%), with SPL being slightly lower in all cases. The additional intensity features that are provided by multispectral ALS appear to be more beneficial to overall accuracy than the higher point density of SPL. We also demonstrate the potential contribution of lidar time-series data in improving classification accuracy (Hardwood/Softwood, 91%; 12 species, 58%; 4 species, 84%). Possible causes for lower SPL accuracy are (a) differences in the nature of the intensity features and (b) differences in first and second return distributions between the two linear systems and SPL. We also show that segmentation (and field-identified training crowns deriving from segmentation) that is performed on an initial dataset can be used on subsequent datasets with similar overall accuracy. To our knowledge, this is the first study to compare these three types of ALS systems for species identification at the individual tree level.
Clustering by Errors: A Self-Organized Multitask Learning Method for Acoustic Scene Classification
Authors: Zheng Weiping , Mo Zhenyao , Zhao Gansen
Published: December 2021

Acoustic scene classification (ASC) tries to inference information about the environment using audio segments. The inter-class similarity is a significant issue in ASC as acoustic scenes with different labels may sound quite similar. In this paper, the similarity relations amongst scenes are correlated with the classification error. A class hierarchy construction method by using classification error is then proposed and integrated into a multitask learning framework. The experiments have shown that the proposed multitask learning method improves the performance of ASC. On the TUT Acoustic Scene 2017 dataset, we obtain the ensemble fine-grained accuracy of 81.4%, which is better than the state-of-the-art. By using multitask learning, the basic Convolutional Neural Network (CNN) model can be improved by about 2.0 to 3.5 percent according to different spectrograms. The coarse category accuracies (for two to six super-classes) range from 77.0% to 96.2% by single models. On the revised version of the LITIS Rouen dataset, we achieve the ensemble fine-grained accuracy of 83.9%. The multitask learning models obtain an improvement of 1.6% to 1.8% compared to their basic models. The coarse category accuracies range from 94.9% to 97.9% for two to six super-classes with single models.
Trajectory Design for UAV-Based Data Collection Using Clustering Model in Smart Farming
Authors: Qayyum Tariq , Trabelsi Zouheir , Malik Asad , Hayawi Kadhim
Published: December 2021

Unmanned aerial vehicles (UAVs) play an important role in facilitating data collection in remote areas due to their remote mobility. The collected data require processing close to the end-user to support delay-sensitive applications. In this paper, we proposed a data collection scheme and scheduling framework for smart farms. We categorized the proposed model into two phases: data collection and data scheduling. In the data collection phase, the IoT sensors are deployed randomly to form a cluster based on their RSSI. The UAV calculates an optimum trajectory in order to gather data from all clusters. The UAV offloads the data to the nearest base station. In the second phase, the BS finds the optimally available fog node based on efficiency, response rate, and availability to send workload for processing. The proposed framework is implemented in OMNeT++ and compared with existing work in terms of energy and network delay.
Opto-Thermal Investigation of Additively Manufactured Steel Samples as a Function of the Hatch Distance
Authors: Höfflin Dennis , Rosilius Maximilian , Seitz Philipp , Schiffler Andreas , Hartmann Jürgen
Published: December 2021

Nowadays, additive manufacturing processes are becoming more and more appealing due to their production-oriented design guidelines, especially with regard to topology optimisation and minimal downstream production depth in contrast to conventional technologies. However, a scientific path in the areas of quality assurance, material and microstructural properties, intrinsic thermal permeability and dependent stress parameters inhibits enthusiasm for the potential degrees of freedom of the direct metal laser melting process (DMLS). Especially in quality assurance, post-processing destructive measuring methods are still predominantly necessary in order to evaluate the components adequately. The overall objective of these investigations is to gain process knowledge make reliable in situ statements about component quality and material properties based on the process parameters used and emission values measured. The knowledge will then be used to develop non-destructive tools for the quality management of additively manufactured components. To assess the effectiveness of the research design in relation to the objectives for further investigations, this pre-study evaluates the dependencies between the process parameters, process emission during manufacturing and resulting thermal diffusivity and the relative density of samples fabricated by DMLS. Therefore, the approach deals with additively built metal samples made on an EOS M290 apparatus with varying hatch distances while simultaneously detecting the process emission. Afterwards, the relative density of the samples is determined optically, and thermal diffusivity is measured using the laser flash method. As a result of this pre-study, all interactions of the within factors are presented. The process variable hatch distance indicates a strong influence on the resulting material properties, as an increase in the hatch distance from 0.11 mm to 1 mm leads to a drop in relative density of 57.4%. The associated thermal diffusivity also reveals a sharp decrease from 5.3 mm2/s to 1.3 mm2/s with growing hatch distances. The variability of the material properties can also be observed in the measured process emissions. However, as various factors overlap in the thermal radiation signal, no clear assignment is possible within the scope of this work.
Optically-Powered Wireless Sensor Nodes towards Industrial Internet of Things
Authors: Souza Letícia C. , Neto Egidio R. , Lima Eduardo S. , Junior Arismar Cerqueira Sodré
Published: December 2021

We report the experimental implementation of optically-powered wireless sensor nodes based on the power-over-fiber (PoF) technology, aiming at Industrial Internet of Things (IIoT) applications. This technique employs optical fibers to transmit power and is proposed as a solution to address the hazardous industrial environment challenges, e.g., electromagnetic interference and extreme temperatures. The proposed approach enables two different IIoT scenarios, in which wireless transmitter (TX) and receiver (RX) nodes are powered by a PoF system, enabling local and remote temperature data monitoring, with the purpose of achieving an intelligent and reliable process management in industrial production lines. In addition, the system performance is investigated as a function of the delivered electrical power and power transmission efficiency (PTE), which is the primary performance metric of a PoF system. We report 1.4 W electrical power deliver with PTE = 24%. Furthermore, we carry out a voltage stability analysis, demonstrating that the PoF system is capable of delivering stable voltage to a wide range of applications. Finally, we present a comparison of temperature measurements between the proposed approach and a conventional industrial programmable logic controller (PLC). The obtained results demonstrate that PoF might be considered as a potential technology to power and enhance the energy efficiency of IIoT sensing systems.
Associations between Fluctuating Shame, Self-Esteem, and Sexual Desire: Comparing Frequent Porn Users and a General Population Sample
Authors: van Tuijl Piet , Verboon Peter , van Lankveld Jacques J. D. M.
Published: December 2021

In the present study, we explore the proposed cyclic models for problematic hypersexuality (PH) that involve shame, self-esteem, and sexual desire. These cyclic models are characterized by temporal associations but have not been investigated previously with intensive longitudinal designs. In this study, we collected up to 70 measurements per participant within a period of seven consecutive days, which allowed us to investigate associations between fluctuations of shame, self-esteem, and sexual desire. Participants were divided in four subgroups: (1) women (n = 87); (2) men (n = 46) from a general population convenience sample; (3) men watching porn >2 times per week, showing non-problematic hypersexuality (NH; n = 10); and (4) men watching porn >2 times per week, experiencing PH (n = 11). Multilevel analyses, including cross-level interactions, were used to investigate between-group differences in intraindividual processes. Results showed that prior increases in shame forecasted higher current sexual desire for men with PH, but not for the other groups, suggesting that men with PH use sexual desire to downregulate dysphoric feelings of shame. Differences between groups in associations between self-esteem and sexual desire were also found. Based on our results, we propose the Split Pleasure/Shame model, which represents emotion dysregulation in PH, and juxtapose this with the pleasurable experience of sex by non-PH groups. Further intensive longitudinal research is necessary to test this model and, more generally, to investigate the fluctuating nature of sexual desire.
Sources of Meaningful Work for Blue-Collar Workers
Authors: Saari Tiina , Leinonen Minna , Tapanila Katriina
Published: December 2021

Research on the meaningfulness of work has increased in recent years, yet there is a limited body of qualitative studies on the topic. This article analyzes how the four basic psychological needs, namely autonomy, competence, relatedness, and beneficence, are articulated as sources of meaningful work by blue-collar workers. The research data consist of responses (N = 679) to one open-ended question in a survey and semi-structured interviews (N = 29) with blue-collar workers from property services and the manufacturing industry in Finland. The data were analyzed by theory-driven content analysis. The main findings are: first, autonomy, competence, relatedness, and beneficence appear as sources of meaningfulness in blue-collar work. Second, blue-collar workers see their work as autonomous and requiring diverse competences. Relatedness in blue-collar work entails having good relations with co-workers and striving to maintain those relationships. Beneficence is multilevel: helping clients, co-workers, organization and even the whole society through work. Organizations should develop organizational practices that may enhance the meaningfulness of work, such as opportunities to use and develop occupational skills. This article participates in the discussion about how satisfying these four basic psychological needs can be a source of meaningful work and offers a sociological-contextual perspective on the discussion about meaningfulness of work.
Active Aging through Later Life and Afterlife Planning: Shūkatsu in a Super-Aged Japan
Authors: Chan Hui Hsien , Thang Leng Leng
Published: December 2021

In Japan, the term shūkatsu—referred as the planning for later life and for the afterlife—has gained popularity due to high amount of mass media exposure in recent years. This paper examines shūkatsu from the active aging framework, contending that shūkatsu is an important activity that contributes to active aging, as the process of conscientious planning encourages older Japanese people to remain active. Data for this study were obtained from qualitative interviews that were conducted with 40 older middle-class Japanese citizens residing in Nagoya. Explored through a life course perspective, the study examined how salient factors, such as personal history, experiences, roles, anxieties, life-changing events, and cultural practices, have influenced older Japanese people in their shūkatsu decision-making process. In the process of understanding how the Japanese respond to changing family relationships and sociocultural transformations, the emphasis on living a “good old age” for better social, psychological, and physical well-being strongly reflects the agency to age actively. In a super-aged Japan, shūkatsu may be a vital strategy that not only ensures a better quality of life for the older population and their children, but it also contributes to individual’s sense of usefulness and satisfaction, as they are actively involved in the planning and management of their own later and afterlife choices.
Gender Parity in Spain: Attainments and Remaining Challenges
Authors: Árbol-Pérez Isabel , Entrena-Durán Francisco
Published: December 2021

The purpose of this article is to study the progress made in Spain in terms of gender parity and the challenges still pending to be achieved in this regard. To attain this objective, first of all, the authors review the successive legal regulations aimed at reaching gender equality that have been enacted in Spain. Furthermore, the considerations and findings made are based on the use of quantitative and qualitative methodologies. On the one hand, from a quantitative viewpoint, different statistical data provided mainly by the Spanish Statistics National Institute are analyzed. From these data, the authors prepare a set of tables and figures that allow them to show that, despite the undoubted legislative advances attained, clear gender inequalities continue in Spain. On the other hand, the authors base their assertions both on their participant observation and on a reinterpretation and reanalysis of the results of two previous qualitative researches. One of the most remarkable outcomes of the use of this qualitative methodology is the persistence in Spain of diverse signs of macho mentality. This persistence not only manifests itself among many men, it is also shared by a large number of women.
The Effect of the OCB Gap on Task Performance with the Moderating Role of Task Interdependence
Authors: Yang Yuha , Chae Heesun
Published: December 2021

Using the social exchange theory and the social cognitive perspective in group dynamics, this study seeks to examine how different individuals in the degree of engagement in organizational citizenship behavior (OCB) among members of a team (i.e., the OCB gap) can affect their work performance across varying levels of task interdependence. The research hypotheses were tested empirically using field data regarding 146 employee-supervisor dyads collected from 41 teams in South Korea. The results of the hierarchical linear modeling (HLM) analysis indicate that having a lover level of OCB engagement than the group average induces feelings of indebtedness in employees, and this sense of obligation is stronger in a high level of task dependence context. We further discuss the theoretical and practical implications of this research and suggest areas for future research.
Comparative Analysis and Statistical Optimization of Fuel Economy for Sustainable Vehicle Routings
Authors: Alsaadi Naif
Published: December 2021

In this 21st century, there has been an increase in the usage of renewable products for the economic drifting of vehicle transportations systems. Furthermore, due to recent trends in climate change, researchers have started focusing on statistical optimization techniques for sustainable vehicle routings. However, until now, a major gap has been noticed in the multidomain statistical analysis for optimizing the parametric levels of the vehicle fuel economy. Therefore, in this research work, two widely utilized cars (Toyota and GMC Yukon) are considered on a particular route of Jeddah for the collection of the fuel economy data under the realistic conditions of air conditioner temperature, traffic patterns, and tire pressure. The outcomes of the factorial design of the experiment highlight that the fuel economy is optimal under the low air conditioner temperature, light traffic patterns, and 34 PSI tire pressure. Three replications of the fuel economy have been considered, and the statistical significance of the correlated variables has been justified by implementing the analysis of variance (ANOVA) approach on the various levels of fuel economy. During the analysis, the statistical hypothesis for random exogenous factors has been developed by incorporating a multivariate regression model. The outcomes highlight that both air conditioner temperature and traffic patterns in Jeddah have a significant negative effect on fuel economy. Results also depict that the effect of air conditioner temperature, traffic patterns, and tire pressure is substantially higher for heavy-engine automobiles such as the GMC Yukon compared to light-engine cars (Toyota Corolla). Furthermore, a normality test has also been considered to validate the outcomes of the proposed model. Therefore, it is highly recommended to utilize the proposed methodology in optimizing the trends of fuel economy for sustainable vehicle routings. Based on the findings of multidomain statistical analysis, it is also highly recommended the utilization of the Toyota Corolla car model for investigating the correlation of external undeniable factors (braking frequency, metrological conditions, etc.) with the trends of vehicle fuel economy.
Psychology of Dwelling and Visual Appropriations—An Anthropological Application
Authors: Mocrei-Rebrean Lucian
Published: December 2021

We find ourselves situated within a world that can be experienced visually, for the first time, in its wholeness. Using conceptual analysis, we intend to show that notions born within the practice of habitation, such as the sense of place, place attachment, and hearth, can help us evaluate the psychological implications of the images of Earth taken from space. We chose a phenomenological approach to human habitation because it allows concepts pertaining to connected and inherently interdisciplinary fields, for instance environmental psychology or human geography, to be reunited under the umbrella of an anthropological interpretation. The sensory and imaginary connotations of the notion of place may be noticed starting from the distinction between space as mathematical abstraction and concrete places being experienced directly. An analysis of the nature of this connection leads to the finding that we actively imagine and reimagine the surrounding world as an unfolding space in which we are constantly attempting to dwell. What is of particular interest for us is the manner in which technologically-mediated visual experience may inspire cognitive representations or may generate profound emotions, such as the attachment to a particular place. Therefore, the value of imagination for the anthropology of habitation is not rendered by its compensatory role, but by its link to ontogenesis. Familiar places, which continue to attract us, are capable of triggering unique imaginary processes, reveries which refer us to the primordial steps of ontogenesis with outmost intensity. The process of subjective appropriation of the world begins with that privileged space of origin specific to each of us, the space which we identify with most intensely. Thus, the psychological impact of the image of Earth from space: we become intensely aware that this planet is our Place within a hostile universe.
Digitalization in Food Supply Chains: A Bibliometric Review and Key-Route Main Path Analysis
Authors: Rejeb Abderahman , Rejeb Karim , Abdollahi Alireza , Zailani Suhaiza , Iranmanesh Mohammad , Ghobakhloo Morteza
Published: December 2021

Technological advances such as blockchain, artificial intelligence, big data, social media, and geographic information systems represent a building block of the digital transformation that supports the resilience of the food supply chain (FSC) and increases its efficiency. This paper reviews the literature surrounding digitalization in FSCs. A bibliometric and key-route main path analysis was carried out to objectively and analytically uncover the knowledge development in digitalization within the context of sustainable FSCs. The research began with the selection of 2140 articles published over nearly five decades. Then, the articles were examined according to several bibliometric metrics such as year of publication, countries, institutions, sources, authors, and keywords frequency. A keyword co-occurrence network was generated to cluster the relevant literature. Findings of the review and bibliometric analysis indicate that research at the intersection of technology and the FSC has gained substantial interest from scholars. On the basis of keyword co-occurrence network, the literature is focused on the role of information communication technology for agriculture and food security, food waste and circular economy, and the merge of the Internet of Things and blockchain in the FSC. The analysis of the key-route main path uncovers three critical periods marking the development of technology-enabled FSCs. The study offers scholars a better understanding of digitalization within the agri-food industry and the current knowledge gaps for future research. Practitioners may find the review useful to remain ahead of the latest discussions of technology-enabled FSCs. To the authors’ best knowledge, the current study is one of the few endeavors to explore technology-enabled FSCs using a comprehensive sample of journal articles published during the past five decades.
Visible Domain Photocatalysis Performance of Ti-Si Thermal-Sprayed Coatings
Authors: Uncu Ionut , Roata Ionut Claudiu , Croitoru Catalin , Machedon-Pisu Teodor
Published: December 2021

Cost and performance-effective materials used in advanced oxidation processes such as photocatalysis have obtained widespread attention in recent years. In this study, thermal spraying was used as a one-step method to obtain thick visible-light-active photocatalyst coatings on two types of substrates, namely, plain carbon steel and copper. A mixed metallic titanium–silicon powder bearing 10% wt. Si was used as feedstock. The optical bandgaps of the coatings were close to 1.000 eV, allowing good photodecoloration efficiencies (>89%) and mineralization efficiencies (>67%) for methylene blue dye from aqueous solutions under visible light irradiation. The photodegradation process could be successfully modelled by the Langmuir–Hinshelwood pseudo-first-order kinetic model, with reaction rate constants k between 0.16 and 1.06 h−1.
Willingness to Pay for Irrigation Services in the Cold Winter Deserts of Uzbekistan
Authors: Kassie Girma T. , Boboev Hasan , Sharma Ram , Akramkhanov Akmal
Published: December 2021

Irrigation facilities in the cold winter deserts (CWDs) of Uzbekistan are very traditional and poorly managed, resulting in low water use efficiency and low productivity. Improving the irrigation facilities in these deserts is a key priority for the country. This study intended to contribute towards the development of the irrigation systems through identification and quantification of the relative implicit values smallholder farmers confer to the key characteristics of irrigation facilities. We elicited preferences with discrete choice experiments, estimated willingness to pay for these attributes using random parameters logit models, and analyzed heuristics in the choice process using a series of latent class models. Our results show that farmers have clear preferences for higher watering frequency and no interest in sharing irrigation water with downstream users. We also observed that there are distinct groups of farmers with comparable but different levels of preference. The development of irrigation facilities in the water-scarce parts of Uzbekistan would benefit from careful consideration of the preferences of the target communities and targeting of the schemes based on the broad heterogeneities within the communities. This will aid in the maintenance of irrigation systems and, as a result, increase agricultural production and productivity.
Digital Gifts and Tourism Mementos: A Sustainable Approach
Authors: Mantas Panagiotis , Ioannou Zafeiria-Marina , Viennas Emmanouil , Pavlidis George , Sakkopoulos Evangelos
Published: December 2021

Touristic destinations all around the world are struggling to digitally transform the touristic experience and the touristic products they offer and to capitalize a good experience with new tourists and returning ones. There is a lot of research on digital solutions assisting tourism, but it does not provide a follow-up digital product, therefore depending only on physical gifts, postcards and mementos. In this work, we propose a novel platform that can provide a personalized digital memento or digital gift for every route or tourist destination that can become the digital point of reference of visitors’ experience giving new dimensions for commercialization to the existing physical mementos at the gift shops. The purpose of this study is to analyze what comprises a memorable touristic experience and to design and, finally, present a total solution that builds and offers a personal e-souvenir of a touristic experience to the tourist for him to hold, sport and share just using his mobile phone. We propose a digital memento-building platform that includes the personalized experience in visits taking place while in vacations. The visitors are usually taking pictures along routes they follow that later need further organization and processing and that in no way substitutes the physical mementos. In our approach, we propose a solution that generates a unique and personalized e-souvenir through a collage of the selfies and photos creating the digital equivalent of the touristic postcards but in our case personalized with the visitor photos with minimum amount of effort and produced real-time. Our approach is also providing a platform to the photographers and designers of touristic destinations to build and graphically generated memento artifacts—templates specific for one or more destinations or routes. In this way, the approach serves the tourism industry vertically, covering all aspects, i.e., the tourist-visitor, the tourism professional players such as photographers, designers of physical mementos and, of course, the touristic destination providing a digital footprint to server marketing of the destination through sharing on social media and word-of-mouth, of course. To support our approach, we have built and run a fully working prototype in the touristic center of Athens, Greece, with real users and designers for several weeks during summer vacations. The results have been greatly encouraging from end-users and professionals. The study shows that it is possible for various lines of business to come together and work along one another for an improve touristic experience using mobile technologies in a personalized, targeted approach. The touristic destination, graphic designers, photographers, tourist agent specialists, software developers and visitors can all now have a digital personalized memorable gift from the visit.
E-Commerce and the Factors Affecting Its Development in the Age of Digital Technology: Empirical Evidence at EU–27 Level
Authors: Bădîrcea Roxana Maria , Manta Alina Georgiana , Florea Nicoleta Mihaela , Popescu Jenica , Manta Florin Liviu , Puiu Silvia
Published: December 2021

The purpose of this study is to identify the factors influencing e-commerce and to evaluate the long and short-term impacts on the development of e-commerce activity. After establishing the hypotheses to verify, we use multiple panel regressions to test the influence of education level, consumer’s residence, consumer’s labour market status, internet banking, mobile and non-mobile users on the development of e-commerce. For this matter, in this paper, by adopting the fully modified ordinary least squares (FMOLS) method and a vector error correction model (VECM), we performed an empirical analysis of the nexus between education level, consumer’s residence, consumer’s labour market status, internet banking and mobile and non-mobile users and e-commerce, based on panel data for EU–27 countries from 2011 to 2020. The results of the study indicate that all the variables involved in the two econometric models and associated with education level, consumer’s residence, labour market status, internet banking, mobile and non-mobile users, all have significant impacts on the development of e-commerce. Most of the variables positively influence the development of e-commerce except for internet purchases by individuals un-employed and for internet purchases by non-mobile users that are negatively correlated with e-commerce activity.
Uremic Toxins and Protein-Bound Therapeutics in AKI and CKD: Up-to-Date Evidence
Authors: Chen Jia-Huang , Chiang Chih-Kang
Published: December 2021

Uremic toxins are defined as harmful metabolites that accumulate in the human body of patients whose renal function declines, especially chronic kidney disease (CKD) patients. Growing evidence demonstrates the deteriorating effect of uremic toxins on CKD progression and CKD-related complications, and removing uremic toxins in CKD has become the conventional treatment in the clinic. However, studies rarely pay attention to uremic toxin clearance in the early stage of acute kidney injury (AKI) to prevent progression to CKD despite increasing reports demonstrating that uremic toxins are correlated with the severity of injury or mortality. This review highlights the current evidence of uremic toxin accumulation in AKI and the therapeutic value to prevent CKD progression specific to protein-bound uremic toxins (PBUTs).
αVβ3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells
Authors: Reis Vinicius Pinho dos , Keller Markus , Schmidt Katja , Ulrich Rainer Günter , Groschup Martin Hermann
Published: December 2021

The Flavivirus genus includes a number of important viruses that are pathogenic to humans and animals and are responsible for outbreaks across the globe. Integrins, a family of heterodimeric transmembrane molecules expressed in all nucleated cells mediate critical functions of cell physiology and cell cycle. Integrins were previously postulated to be involved in flavivirus entry and to modulate flavivirus replication efficiency. In the present study, mouse embryonic fibroblasts (MEF), lacking the expression of αVβ3 integrin (MEF-αVβ3−/−), were infected with four different flaviviruses, namely yellow fever virus (YFV), West Nile virus (WNV), Usutu virus (USUV) and Langat virus (LGTV). The effects of the αVβ3 integrin absence in double-knockout MEF-αVβ3−/− on flavivirus binding, internalization and replication were compared to the respective wild-type cells. Binding to the cell surface for all four flaviviruses was not affected by the ablation of αVβ3 integrin, whereas internalization of USUV and WNV was slightly affected by the loss of αVβ3 integrin expression. Most interestingly, the deletion of αVβ3 integrin strongly impaired replication of all flaviviruses with a reduction of up to 99% on virus yields and a strong reduction on flavivirus anti-genome RNA synthesis. In conclusion, our results demonstrate that αVβ3 integrin expression in flavivirus-susceptible cell lines enhances the flavivirus replication.
Prediction of Novel Drug Targets and Vaccine Candidates against Human Lice (Insecta), Acari (Arachnida), and Their Associated Pathogens
Authors: Ali Abid , Ahmad Shabir , de Albuquerque Pedro Machado Medeiros , Kamil Atif , Alshammari Fahdah Ayed , Alouffi Abdulaziz , da Silva Vaz Itabajara
Published: December 2021

The emergence of drug-resistant lice, acari, and their associated pathogens (APs) is associated with economic losses; thus, it is essential to find new appropriate therapeutic approaches. In the present study, a subtractive proteomics approach was used to predict suitable therapeutics against these vectors and their infectious agents. We found 9701 proteins in the lice (Pediculus humanus var. corporis) and acari (Ixodes scapularis, Leptotrombidium deliense), and 4822 proteins in the proteomes of their APs (Babesia microti, Borreliella mayonii, Borrelia miyamotoi, Borrelia recurrentis, Rickettsia prowazekii, Orientia tsutsugamushi str. Boryong) that were non-homologous to host proteins. Among these non-homologous proteins, 365 proteins of lice and acari, and 630 proteins of APs, were predicted as essential proteins. Twelve unique essential proteins were predicted to be involved in four unique metabolic pathways of lice and acari, and 103 unique proteins were found to be involved in 75 unique metabolic pathways of APs. The sub cellular localization analysis of 115 unique essential proteins of lice and acari and their APs revealed that 61 proteins were cytoplasmic, 42 as membrane-bound proteins and 12 proteins with multiple localization. The druggability analysis of the identified 73 cytoplasmic and multiple localization essential proteins revealed 22 druggable targets and 51 novel drug targets that participate in unique pathways of lice and acari and their APs. Further, the predicted 42 membrane bound proteins could be potential vaccine candidates. Screening of useful inhibitors against these novel targets may result in finding novel compounds efficient for the control of these parasites.
The Effectiveness of Post-Vaccination and Post-Infection Protection in the Hospital Staff of Three Prague Hospitals: A Cohort Study of 8-Month Follow-Up from the Start of the COVID-19 Vaccination Campaign (COVANESS)
Authors: Petráš Marek , Lesná Ivana Králová , Večeřová Livia , Nyčová Elka , Malinová Jana , Klézl Petr , Nezvedová Martina , White Rachel Elizabeth , Máčalík Roman , Dáňová Jana , Čelko Alexander M. , Adámková Věra
Published: December 2021

Continuous assessment of the effectiveness of approved COVID-19 vaccines is crucial to gain an insight into the longer-term impact on health outcomes, and eventually boosting public confidence. For this reason, we conducted a multicenter, retrospective cohort study using data on infection and vaccination rates among employees of three Prague hospitals in the period between 27 December 2020 and 31 August 2021. The post-vaccination and post-infection protectiveness were assessed in a total of 11,443 hospital workers who were followed up for more than 14 days either after their Comirnaty vaccination or study enrolment, depending on their previous SARS-CoV-2 infection. The effectiveness of full vaccination against any SARS-CoV-2 infection achieved 88.3% (83.2–91.8%) over the eight months of follow-up, a figure not much different from the 92.5% (76.5–97.6%) level of protection built by a previous infection. Despite this, the post-vaccination level of protection declined to about 65% between June and August. No case of breakthrough infection was registered among hospital workers having received one or two vaccine doses more than three months after previous infection. The eight-month effectiveness of the Comirnaty vaccine exhibited a declining trend requiring a new booster dose. The need for vaccination in the previously infected employees was not demonstrated conclusively in this study.
Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer
Authors: Kim Young Jin , Kim Chang Hyun
Published: December 2021

From the perspective of survival outcomes, the cancer survival of colorectal cancer (CRC) in the whole stage has improved. Peritoneal metastasis (PM) is found in approximately 8% to 15% of patients with CRC, with a poorer prognosis than that associated with other sites of metastases. Randomized controlled trials and up-to-date meta-analyses provide firm evidence that cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) could significantly improve overall survival compared with systemic chemotherapy alone in selected patients with CRC-PM. Practical guidelines recommend that the management of CRC-PM should be led by a multidisciplinary team carried out in experienced centers and consider CRS plus HIPEC for selected patients. In this review, we aim to provide the latest results of land mark studies and an overview of recent insights with regard to the management of CRC-PM.
World ratings: features of formation and impact on the on the country’s economic growth
Authors: Shmahelska Marina
Published: December 2021

The article investigates the ratings formation as a special type of activity that is actively implemented in a market economy. The process of creating a rating system is considered. It is established that the analysis results of economic entities activities are expressed as the results of evaluation in the rating scale. The main difference between the concepts of «rating» and «ranking» is determined, which allows building economic entities according to the ranking, that is, according to one of the indicators. The criteria that underlie the classification of ratings are analyzed. It is noted that in the economic literature, in most cases, it is carried out by rating agencies and companies. It is established that the rating process, as a business, has not only a methodological, but also a certain moral component. The regulatory element of rating agencies and features of their national and international rating scales are studied. A set (system) of national rating scales are determined, which provides the most complete and objective assessment of the issuer’s creditworthiness. The ratings of international rating agencies, which are assigned, usually, on two scales: international and national, are studied. It has been proven that changes in ratings play an important role for transactions with interest rate risks, as information for investors in decision making. The main methods of rating are established, which are largely closed. The leading credit ratings of international agencies, which are used by portfolio investors in decision-making, including country and regional ratings, are named. The main advantages that provide credibility to the ratings are substantiated, such as: the agency’s reputation; the agency has a generally recognized and accessible reporting methodology; differences in approaches to the analysis of rating subjects.
Chinese social credit system: key features and possibility of using in Ukraine
Authors: Shved Vadym
Published: December 2021

The article considers the key features of the social credit (rating) system implementation and functioning, which is the main tool for digitalization of Chinese society, and in the future is considered by the Chinese authorities as a basic mechanism of electronic government. The historical retrospective of the phenomenon of social rating emergence and development, which was later transformed into social credit, is presented. Attention is paid to the differences in the implementation and functioning of the social credit system, depending on regional characteristics. The participants in the social credit system and the main mechanisms for collecting information for the social credit level formation, including through the mandatory use of specially designed ID-cards, and recently the almost widespread use of the verification for a person by face, have been determined. Despite the position of the Chinese authorities, according to which the use of the social credit system is successful, a list of shortcomings that are now inherent in this system, both of an author’s and of an expert nature, is given. The practice of implementation the state digital eco-environment «Diia» (State and I), which is a key tool for building a digital state, as well as the functional content of the «Diia» eco-environment (service) and its main components, is analyzed. The basic shortcomings that are now inherent in the service are determined, in particular, the key tool in the fight against coronavirus – «Diia. Vdoma», as well as the controversial character of the proposed innovation for the business environment «Diia. City». The features of the declared novel of the relationship between the citizen and state ‒ the concept of «paperless», are studied. The issue of regulation of the «Diia» eco-environment functioning is raised in the context of the legislative introduction of the concept of «paperless» announced on September 1, 2021. The conclusion is substantiated that the basic mechanisms are already being introduced in Ukraine, which form the basis for the Chinese social credit system functioning, in particular, through the tools of citizensʼ verification. On the basis of the analysis carried out, proposals are made to improve the functionality of the «Diia» eco-environment.
THE MAIN DIRECTIONS OF MODERNIZATION OF TRAINING OF THE FUTURE BIOLOGY TEACHERS FOR THE IMPLEMENTATION OF HEALTH-SAVING TECHNOLOGIES IN PROFESSIONAL WORK
Authors: DYACHENKO-BOHUN M. , MICHEENKO A. , GAFIAK A.
Published: December 2021

In the article the basic directions of modernization of training of the future biology teachers for the implementation of health-saving technologies in professional work. The modernization of the educational process in higher educational institutions provide a qualitative transformation of biology training future teachers to realization health-saving technologies on par with the best international standards. The necessity of the use of interactive teaching methods, the individualization of the educational process, the widespread involvement of advanced multimedia and Internet technologies.

Ways to improve the teaching of natural sciences and implement innovative systems for training of teachers in healthcare is fundamentalization training, competence development, the use of active forms and methods of teaching. These areas of modernization of the educational process in higher educational institutions will provide qualitative transformation of the biology training of teachers to implement technology to preserve the health of the world's best standards.

Support innovation orientation training future teachers of natural sciences to implement health-saving technologies in educational institutions in the conditions of possible learning environment that combines educational and scientific activities, implements innovative research and educational programs

This will ensure the readiness of future biology teachers to use technology to preserve the health of their educational activities.
PECULIARITIES OF ORGANIZATION OF UNIVERSITY STUDENTS OF LINGUISTIC DEPARTMENTS’ DISTANT LEARNING «THEORETICAL COURSE OF THE EGLISH LANGUAGE»
Authors: ZADIL’S’KA H.
Published: December 2021

High requirements to quality of professional preparation of university students of linguistic departments at distant learning open wide access to the educational and educational resources that give possibilities to great students’ activity and fundamentally new means of their studies. The purpose of the article is to reveal the content of innovative teaching methods in the process of distant learning for the formation of the professional competence to university students of linguistic departments in theoretical course of the English language. A great number of research workers have been involved in the study of different problems of theory and practice of distant learning to university students of linguistic departments, but the problem must be investigated deeper at the present situation with Covid 19.The article emphasizes the need to find the ways to integrate the latest technologies into the distant learning process. Emphasis is placed on innovative learning technologies that have been successfully implemented in the present day educational process. The use of the Internet and computer technologies in the process of teaching English to university students of linguistic departments will increase students’ interest and motivation for learning, their communicative competence. The article deals with the peculiarities of using the Internet and computer technologies, modern platforms and programmes in teaching English at the process of distant learning. The article contains descriptions of such modern platforms as Zoom, GoogleClassroom, LearningApps and such programmes as English Audio Books, English Stories (Offline), Practice English Speaking та English Speaking PracticeApp, as well as the possibilities of their use in the process of teaching speaking, listening comprehension, reading and writing to university students of linguistic departments. All of the programs and online resources described in the article are free and accessible to an English teacher. The teacher can use a certain set of Internet resources, but also to create the own materials necessary for learning.