bluuebunny/crossref_metadata_2025 huggingface dataset:
Identificação dos fluxos de escoamento superficial em área de relevo tecnogênico a partir do uso de modelos hidrológicos em SIG
Authors: Mathias Dener Toledo , Lupinacci Cenira Maria , Nunes João Osvaldo Rodrigues
Published: November 2020

Este artigo apresenta os resultados do mapeamento das rotas de fluxo do escoamento superficial em área caracterizada por intensas modificações do relevo causadas por intervenções antrópicas. Como estudo de caso foi escolhida a alta bacia do córrego Tucum (São Pedro - SP), por apresentar um cenário marcado pelo avanço da urbanização sobre terrenos com forte suscetibilidade à erosão, com a presença de feições erosivas lineares (ravinas e voçorocas), e um complexo histórico de intervenções buscando o controle de tais processos. Foram utilizados dados primários, obtidos a partir de levantamento topográfico em campo, e executadas operações visando à elaboração de um Modelo Digital de Elevação Hidrologicamente Consistente (MDEHC), no programa ArcGIS 10.1. Em seguida, foi elaborada a Carta de Fluxo Concentrado da área, a partir da modelagem através do algoritmo Multiple Flow, no programa ArcView 3.2. Os resultados permitiram constatar que feições topográficas de detalhe, em especial, terraços tecnogênicos, têm exercido controle marcante sobre as rotas de fluxo do escoamento superficial, contribuindo para a geração de vetores de avanço erosivo das ravinas e voçorocas existentes na área.
Determinación de la eficacia de antihelmínticos para el tratamiento de la gastroenteritis verminosa en caprinos de la provincia de Tucumán
Authors: CHOCOBAR Marianna , DIAMBRA Priscilla , TERÁN ALURRALDE María Del Rosario , BUSTOS María José , PRADO José María , GONZÁLEZ MORENO Candelaria , FERNÁNDEZ Jorge L. , SALINAS Carmen , SOLALIGUE Paola , ROSA Ramiro J.
Published: November 2020

En la Argentina, el 93% de la producción caprina en la Argentina es desarrollada por pequeños productores de agriculturas de subsistencia, quienes, por lo general, utilizan antihelmínticos sin asesoramiento profesional, lo que, probablemente, ha llevado al desarrollo de resistencia, comprometiendo seriamente la sustentabilidad del control de nematodos. El objetivo de este estudio es determinar la eficacia de la ivermectina, el albendazol y el levamisol para el tratamiento de la gastroenteritis verminosa en cuatro grupos de ocho caprinos cada uno, mediante el Test de Reducción del Conteo de Huevos (TRCH). Los resultados demostraron un 100% de reducción del número de HPG para los grupos tratados con albendazol y levamisol y un 17% de reducción para el grupo tratado con ivermectina, con respecto al grupo control, lo que permite inferir que existe resistencia a este fármaco
CBCTBMF decide, em reunião com o Conselho Geral, o adiamento do COBRAC para 2021
Authors: Filho José Rodrigues Laureano
Published: November 2020

O Colégio Brasileiro de Cirurgia e Traumatologia Bucomaxilofacial definiu, em reunião virtual com o Conselho Geral do CBCTBMF, em 18 de agosto, pelo adiamento do COBRAC para junho de 2021. O evento, que seria realizado em junho de 2020, foi adiado para novembro do mesmo ano, devido à COVID-19. Mas, como a pandemia e muitas incertezas persistem, a decisão por um novo adiamento foi tomada com base em uma série de considerações e, também, com o respaldo de uma pesquisa realizada com os participantes inscritos no evento.
Distribusi Bahan Organik pada Sedimen Permukaan Teluk Kelabat, Pulau Bangka
Authors: Nugraha Mohammad Agung , Hudatwi Mu’alimah
Published: November 2020

Transport of organic material in coastal areas plays an important role in the global biogeochemical cycle. The purpose of this study was to examine the distribution of organic material in sediments and to identify sources of organic material in the Kelabat Bay waters. TOC and TN sediments were analyzed by the Walkley Black and Kjeldahl method. The value of TOC, TN, and C/N ratio obtained in the Kelabat Bay waters sediments ranged from 0.04-7.25%, 0.04-0.14%, and 0.67-65.91. The distribution of TOC, TN, and C/N ratio in Kelabat Bay sediments shows that the value in the inner Kelabat Bay is higher than the outside. The source of organic material input in the inner Kelabat Bay comes mainly from terrestrial, while the outer Kelabat Bay mainly comes from aquatic. Transport bahan organik pada wilayah pesisir memainkan peran penting dalam siklus biogeokimia secara global. Tujuan penelitian ini untuk mengkaji distribusi bahan organik pada sedimen serta identifikasi sumber bahan organik perairan Teluk Kelabat. TOC dan TN sedimen dianalisis dengan metode Walkley Black dan Kjeldahl. Nilai TOC, TN, dan rasio C/N yang diperoleh pada sedimen perairan Teluk Kelabat berkisar antara 0,04-7,25%, 0,04-0,14%, dan 0,67-65,91. Distribusi TOC, TN, serta rasio C/N pada sedimen Teluk Kelabat memperlihatkan nilai pada Teluk Kelabat bagian dalam lebih tinggi dibandingkan bagian luar. Sumber masukan bahan organik pada Teluk Kelabat bagian dalam utamanya berasal dari terestrial, sedangkan Teluk Kelabat bagian luar utamanya berasal dari akuatik.
Integral representation for energies in linear elasticity with surface discontinuities
Authors: Crismale Vito , Friedrich Manuel , Solombrino Francesco
Published: November 2020

In this paper we prove an integral representation formula for a general class of energies defined on the space of generalized special functions of bounded deformation (GSBDp{\mathrm{GSBD}^{p}}) in arbitrary space dimensions. Functionals of this type naturally arise in the modeling of linear elastic solids with surface discontinuities including phenomena as fracture, damage, surface tension between different elastic phases, or material voids. Our approach is based on the global method for relaxation devised in [G. Bouchitté, I. Fonseca and L. Mascarenhas, A global method for relaxation, Arch. Ration. Mech. Anal. 145 1998, 1, 51–98] and a recent Korn-type inequality inGSBDp{\mathrm{GSBD}^{p}}, cf. [F. Cagnetti, A. Chambolle and L. Scardia, Korn and Poincaré–Korn inequalities for functions with a small jump set, preprint 2020]. Our general strategy also allows to generalize integral representation results inSBDp{\mathrm{SBD}^{p}}, obtained in dimension two [S. Conti, M. Focardi and F. Iurlano, Integral representation for functionals defined onSBDp\mathrm{SBD}^{p}in dimension two, Arch. Ration. Mech. Anal. 223 2017, 3, 1337–1374], to higher dimensions, and to revisit results in the framework of generalized special functions of bounded variation (GSBVp{\mathrm{GSBV}^{p}}).
Factores pronósticos de gravedad de la infección por SARS-CoV-2
Authors: Rubio Sánchez Ricardo , Lepe Balsalobre Esperanza , Viloria Peñas María del Mar
Published: November 2020

Objetivos

El SARS-CoV-2 es un nuevo coronavirus, responsable de la enfermedad COVID-19. Entre las alteraciones de los parámetros de laboratorio se han descrito leucocitosis con linfopenia, neutrofilia y aumento de dímero D, proteína C reactiva, ferritina, procalcitonina y lactato deshidrogenasa. El objetivo de este estudio ha sido describir las características clínicas y los parámetros de laboratorio de pacientes ingresados con infección por SARS-CoV-2 e identificar factores pronósticos de progresión de la enfermedad.

Materiales

Los pacientes incluidos en el estudio fueron clasificados en dos grupos en función de la gravedad de la infección. Los variables estudiadas fueron los datos demográficos, antecedentes personales, días de ingreso hospitalario, evolución del cuadro neumónico, tratamiento farmacológico y parámetros analíticos. Se realizó un análisis descriptivo de los datos recogidos, así como un análisis multivariante para identificar factores pronósticos de gravedad de la infección.

Resultados

La población de este estudio incluyó a 197 pacientes, considerándose 127 leves y 70 graves. Se encontraron diferencias estadísticamente significativas entre los dos grupos en la mayoría de los parámetros de laboratorio. El análisis multivariante incluyó como factores pronósticos de gravedad la edad avanzada, niveles elevados de leucocitos y concentraciones aumentadas de proteína C reactiva (PCR), γ-glutamiltransferasa (GGT) y procalcitonina (PCT) en el momento del ingreso hospitalario.

Conclusiones

Los factores pronósticos de gravedad de la infección por SARS-CoV-2 identificados en este estudio (edad, leucocitos, PCR, GGT y PCT) permiten predecir el curso de la enfermedad en las etapas iniciales.
Fluctuating neurological symptoms: should I call the neurologist or the hematologist?
Authors: Losa-Rodríguez Rita , Pérez Martínez Carmen , Rodríguez Pérez Gabriel , de la Fuente Graciani Ignacio , Gómez García Lara M.
Published: November 2020

Objectives

The objective of this study was to highlight the role of the clinical laboratory and the relevance of reporting the case immediately to the unit of hematology for the diagnosis and early administration of treatment in the presence of such an urgent hematologic disease as thrombotic thrombocytopenic purpura (TTP).

Case presentation

An elderly patient was referred to the emergency department of our hospital by his general practitioner for speech difficulty, facial asymmetry and weakness in the upper limb. Stroke code was activated. However, laboratory findings (anemia, thrombocytopenia, elevated creatinine, total bilirubin and LDH, negative direct Coombs test) and presence of schistocytes in the peripheral blood smear test were consistent with a completely different diagnosis: TTP thrombotic microangiopathy.

Conclusions

The first diagnostic approach of left hemispheric stroke was not confirmed in the laboratory, with findings of nonautoimmune hemolytic anemia, thrombocytopenia without apparent cause and presence of schistocytes. We should not forget that the clinical manifestations of this condition are widely variable and may include multiorganic dysfunction. Although confirmation of diagnosis is based on ADAMTS-13, its associated high mortalitiy requires immediate treatment on mere suspicion.
A study on the bacterial adhesion of Streptococcus mutans in various dental ceramics: In vitro study
Authors: Bislimi Fuat , Bajevska Jagoda , Garai Mrinmoy , Reka Arianit A.
Published: November 2020

Streptococcus mutans(S. mutans) has been identified as a major etiologic agent of human dental caries and forms a significant proportion of oral streptococci in carious lesions. This study investigates the correlation of surface properties (effect of contact angle [CA] and free surface energy) on three restorative materials (zirconia, nickel–chromium–molybdenum alloy and composites) used in dental prosthetics with bacterial adhesion toS. mutans. Ten samples of each material (zirconia, nickel–chromium–molybdenum alloy and composites) of 8 mm diameter and 2.5 mm thickness were used. Aqueous CA measurements, free surface energy and bacterial adhesion to the sample surfaces were performed. Bacterial adhesion is determined by planting samples in the blood agar cultures and using an electron microscope (scanning electron microscopy [SEM]). The highest values of bacterial adhesion are found in composites, followed by the metal alloy, while the lowest values are observed in zirconia. Measurements show that zirconia has 17 bacteria; Ni–Cr–Mo alloy has 65, while the composite has 80 bacteria. The composites showed the highest degree of bacterial adhesion, compared to the other investigated materials, which correlates with the free surface energy of the samples (24.31 mJ/m2for zirconia, 31.78 mJ/m2for Ni–Cr–Mo alloy and 48.82 mJ/m2for the composite).
An improved reduction method for phase stability testing in the single-phase region
Authors: Nichita Dan Vladimir , Secuianu Catinca
Published: November 2020

A new reduction method for mixture phase stability testing is proposed, consisting in Newton iterations with a particular set of independent variables and residual functions. The dimension of the problem does not depend on the number of components but on the number of components with nonzero binary interaction parameters in the equation of state. Numerical experiments show an improved convergence behavior, mainly for the domain located outside the stability test limit locus in the pressure–temperature plane, recommending the proposed method for any applications in which the problematic domain is crossed a very large number of times during simulations.
Fast Tensor Product Schwarz Smoothers for High-Order Discontinuous Galerkin Methods
Authors: Witte Julius , Arndt Daniel , Kanschat Guido
Published: November 2020

We discuss the efficient implementation of powerful domain decomposition smoothers for multigrid methods for high-order discontinuous Galerkin (DG) finite element methods. In particular, we study the inversion of matrices associated to mesh cells and to the patches around a vertex, respectively, in order to obtain fast local solvers for additive and multiplicative subspace correction methods. The effort of inverting local matrices for tensor product polynomials of degree k is reduced from

𝒪
⁢

(

k

3
⁢
d

)

{\mathcal{O}(k^{3d})}

to

𝒪
⁢

(

d
⁢

k

d
+
1

)

{\mathcal{O}(dk^{d+1})}

by exploiting the separability of the differential operator and resulting low rank representation of its inverse as a prototype for more general low rank representations in space dimension d.
Explore the application of high-resolution nighttime light remote sensing images in nighttime marine ship detection: A case study of LJ1-01 data
Authors: Zhong Liang , Liu Xiaosheng , Yang Peng , Lin Rizhi
Published: November 2020

Nighttime light remote sensing images show significant application potential in marine ship monitoring, but in areas where ships are densely distributed, the detection accuracy of the current methods is still limited. This article considered the LJ1-01 data as an example, compared with the National Polar-orbiting Partnership (NPP)/Visible Infrared Imaging Radiometer Suite (VIIRS) data, and explored the application of high-resolution nighttime light images in marine ship detection. The radiation values of the aforementioned two images were corrected to achieve consistency, and the interference light sources of the ship light were filtered. Then, when the threshold segmentation and two-parameter constant false alarm rate methods are combined, the ships’ location information was with obtained, and the reliability of the results was analyzed. The results show that the LJ1-01 data can not only record more potential ship light but also distinguish the ship light and background noise in the data. The detection accuracy of the LJ1-01 data in both ship detection methods is significantly higher than that of the NPP/VIIRS data. This study analyzes the characteristics, performance, and application potential of the high-resolution nighttime light data in the detection of marine vessels. The relevant results can provide a reference for the high-precision monitoring of nighttime marine ships.
Slope stability evaluation using backpropagation neural networks and multivariate adaptive regression splines
Authors: Liao Zhihao , Liao Zhiwei
Published: November 2020

Slope stability assessment is a critical concern in construction projects. This study explores the use of multivariate adaptive regression splines (MARS) to capture the intrinsic nonlinear and multidimensional relationship among the parameters that are associated with the evaluation of slope stability. A comparative study of machine learning solutions for slope stability assessment that relied on backpropagation neural network (BPNN) and MARS was conducted. One data set with actual slope collapse events was utilized for model development and to compare the performance of BPNN and MARS. Research results suggest that BPNN and MARS models can model the relationship between the safety factor and the slope parameters. Also, the MARS model has the advantages of computational efficiency and easy interpretation.
On the Skitovich–Darmois theorem for complex and quaternion random variables
Authors: Feldman Gennadiy
Published: November 2020

We prove the following theorem. Let

α
=

a
+

i
⁢
b

{\alpha=a+ib}

be a
nonzero complex number. Then the following statements hold: (i)
Let either

b
≠
0

{b\neq 0}

or

b
=
0

{b=0}

and

a
>
0

{a>0}

. Let

ξ
1

{\xi_{1}}

and

ξ
2

{\xi_{2}}

be
independent complex random variables. Assume that the linear forms

L
1

=

ξ
1

+

ξ
2

{L_{1}=\xi_{1}+\xi_{2}}

and

L
2

=

ξ
1

+

α
⁢

ξ
2

{L_{2}=\xi_{1}+\alpha\xi_{2}}

are independent. Then

ξ
j

{\xi_{j}}

are degenerate random variables. (ii) Let

b
=
0

{b=0}

and

a
<
0

{a<0}

.
Then there exist complex Gaussian random variables in the wide sense

ξ
1

{\xi_{1}}

and

ξ
2

{\xi_{2}}

such that they are not complex Gaussian random
variables in the narrow sense, whereas the linear forms

L
1

=

ξ
1

+

ξ
2

{L_{1}=\xi_{1}+\xi_{2}}

and

L
2

=

ξ
1

+

α
⁢

ξ
2

{L_{2}=\xi_{1}+\alpha\xi_{2}}

are independent.
Hecke
*
*
-algebras on locally compact hypergroups
Authors: Tabatabaie Seyyed Mohammad , Sadathoseyni Bentolhoda
Published: November 2020

In this paper, for a discrete hypergroup K and its subhypergroup H, we initiate the related Hecke

*

{*}

-algebra which is an extension of the classical one, and study its basic properties. Especially, we give a necessary and sufficient condition (named (β)) for this algebra to be associative. Also, we show that this new structure is an associative

*

{*}

-algebra if and only if K is a locally compact group.
Effects of quenching and partitioning (Q&P) technology on microstructure and mechanical properties of VC particulate reinforced wear-resistant alloy
Authors: Zhang Bo , Zeng Song-Sheng
Published: November 2020

To improve the wear resistance, toughness, and hardness of alloy, the quenching and partitioning (Q&P) technology was applied in the VC particulate (VCp) reinforced wear-resistant alloys, which were prepared by adding different Mn contents (2–5 wt%). The effects of partitioning time on the distribution of alloying elements shown by EDX mapping, retained austenite fraction, microstructure, macro-hardness, and impact toughness were investigated. The results showed that the effect of carbon partitioning time on the hard phase of the wear-resistant alloy was not significant. However, the carbon partitioning time greatly affected the microstructure and the mechanical properties of alloys, such as retained austenite, hardness, and impact toughness, and there was also a strong correlation with the Mn content. When the Mn content was lower (2.51 wt%), the retained austenite content increased with the carbon partitioning time, which resulted in decreased hardness and increased impact toughness. However, when the Mn content was higher (4.52 wt%), the opposite results occurred. This study provided an application of the Q&P technology in a VCp-reinforced wear-resistant alloy.
Gr. ἀρτιεπής, ved. ṛtvíya‑ vā́k‑, jav. raϑβiiavacah‑
Authors: Massetti Laura
Published: November 2020

The Homeric compound ἀρτιεπής can be understood as a possessive-compound with a case-form or an adverb in the first member. The compound can be connected to the idea of [CORRECT/RIGHT - SAY], and as such to the expression ἄρτια βάζειν ‘to tell right things’ (Hom.). A collocation [*(H)ar‑ - *u̯eku̯‑] lies at the basis of several IIr. compounds and collocations that are etymologically related to ἀρτιεπής: Ved. ṛtavāká‑, Av. arəm.uxti‑, Ved. [ṛtám - say]. Among others, some striking matches can be identified: Ved. ṛtvíya‑ vā́k‑ and YAv. raϑβiia‑ vacah‑, as well as YAv. vacah‑ - ratumant‑, where the tu‑derivatives parallel the ti‑derivatives (Gk. ἄρτι : *arti‑ or *art‑i‑); YAv. arš.uxδa‑, arš.vacah‑ (OAv. ərəš.vacah‑) which may be interpreted as structural matches, probably containing an adverb as first member of compound.
History of the Albanian present suffix ‑i/‑ën from Proto-Indo-European to the modern dialects
Authors: Lopuhaä-Zwakenberg Milan
Published: November 2020

In standard Albanian, there is a restricted class of three intransitive verbs (hip-, ec-, ik-) that shows a suffix ‑i/‑ën in the conjugation of the present singular. In dialects and in Old Albanian, however, this suffix is more prolific. This paper studies the history of this suffix and its function by comparing its use in a wide range of Albanian dialects. Based on the dialectal data a Proto- Albanian inchoative/imperfective function inherited from Proto-Indo-European can be reconstructed for the suffix. This function is still present in the Arbëresh dialect of San Costantino Albanese. As the suffix lost its semantic component, it became a marker for the imperfect in Tosk and southern Geg, while in northern Geg the suffix is used as a present marker in verbs where ambiguity with the imperfect could arise. The verbs hip-, ec-, and ik- were originally transitive verbs which were intransitivized by the suffix ‑i/‑ën. As their original transitive meaning was lost, the suffix was obligatory in these verbs in Proto-Albanian already, a situation that is continued in almost all present dialects.
Zur Entwicklung von ἑκὼν εἶναι im Altgriechischen
Authors: Conti Luz
Published: November 2020

In the construction ἑκὼν εἶναι, grammars identify the function of εἶναι either with the function of an old dative or accusative. However, some scholars consider εἶναι redundant because it is difficult to ascertain its exact semantic and syntactic function. In any case, neither the original meaning of εἶναι in this construction nor the functional relationship of ἑκών with the infinitive has been described satisfactorily. The semantic, syntactic, and pragmatic differences between ἑκών and ἑκὼν εἶναι have not been determined either. This paper analyzes both ἑκών and εἶναι based on a selection of works of different chronology and genres in order to propose both a diachronic and a synchronic explanation of the construction ἑκὼν εἶναι. The data analysis supports the interpretation of εἶναι as a limitative infinitive that developed into a focusing element. In sentences with negative polarity, ἑκὼν εἶναι has regularly evolved into a parenthetical, specifically a self-correction parenthetical.
Syntax of the Hittite infinitive
Authors: Sideltsev Andrei V.
Published: November 2020

The paper reevaluates the evidence for dative case marking of the direct object of the infinitive in Hittite against the Indo-European and cross-linguistic background. It provides a full corpus of relevant examples in Hittite, suggests a new taxonomy of them and proposes that a syntactic rule has to be formulated to account for the non-finite contexts where dative case marks the direct object of the infinitive in Hittite.
Characterization and prevalence of obesity among normal weight college students
Authors: Anderson Kara C. , Hirsch Katie R. , Peterjohn Austin M. , Blue Malia N.M. , Pihoker Alexis A. , Ward Dianne S. , Ondrak Kristin S. , Smith-Ryan Abbie E.
Published: November 2020

Normal weight obesity (NWO) describes individuals who have a normal weight body mass index (BMI), but have an unhealthy amount of body fat. Based on the life-long habits that develop during college, exploring NWO among a college-aged population may be essential in identifying and preventing obesity that develops in early adulthood. This study aimed to characterize NWO among young adults with normal weight BMI. 94 college students (Mean ± SD: Age: 19.6 ± 1.5 yrs; BMI: 21.9 ± 1.8 kg/m2) enrolled during the Fall semester (Aug-Oct) were assessed for body composition by dual energy X-ray absorptiometry to determine body fat percentage, fat mass, lean mass and trunk fat; lifestyle habits were characterized from validated questionnaires. Mean arterial pressure and metabolic biomarkers [total cholesterol, high density lipoproteins, non-high density lipoproteins, and glucose] were evaluated for cardiometabolic health. NWO was defined using data from the National Health and Nutrition Examination Survey (NHANES) for body fat percentage. Data was analyzed by group (NWO vs NWL) and sex. with independent t-tests to investigate continuous data, and chi-square test of independence for categorical data. Rates of NWO for the total sample were 13.8%. Males (n=30) had a higher rate of NWO (26.7%) compared to females (n=64; 7.8%). NWO individuals had higher fat mass (p=0.024), trunk fat (p<0.001), and larger waist to hip ratio (p<0.001) than normal weight lean. NWO also engaged in less vigorous physical activity (p=0.043). The occurrence of NWO among otherwise healthy college students is evident. Identification of these individuals may be an effective component for obesity prevention and treatment. Determining feasible methods to measure body fat in this population is essential, as BMI may mask obesity in a young adult population.
Separation of copper and indium from zinc hydrometallurgy solution
Authors: Deng Zhigan , Zheng Yu , Li Xingbin , Wei Chang , Li Minting , Li Cunxiong , Fan Gang
Published: November 2020

The separation and recovery of copper and indium from a solution arising from the reductive leaching of a zinc leaching residue was studied. Copper was enriched into a copper precipitate produced by iron powder precipitation; indium was hydrolyzed and enriched into a gypsum indium precipitate produced by limestone adjustment of pH. Separation and recovery of both copper and indium were achieved. The results showed that precipitation of copper(II) and arsenic(III) as Cu2O and Cu3As is thermodynamically feasible by adding iron powder to the reductive leach of a zinc leaching residue. Increasing the iron powder addition and reaction temperature promoted the formation of Cu2O and Cu3As. In the process of neutralizing and precipitating indium by adjusting the pH using limestone, indium was mainly concentrated in the precipitate by hydrolytic precipitation. The pH of the neutralization endpoint plays a decisive role in this hydrolytic enrichment. The extent of indium precipitation exceeded 98%, and the indium content of the precipitate reached 3.6 kg/t. Addition of limestone balances the acid across the entire production process. The main phase in the gypsum indium precipitate was CaSO4·2H2O, the stable properties of which create favorable conditions for the recovery of indium in subsequent steps.
Analysis of (α,β)-order coupled implicit Caputo fractional differential equations using topological degree method
Authors: Riaz Usman , Zada Akbar
Published: November 2020

This article is devoted to establish the existence of solution of(α,β)$\left(\alpha ,\beta \right)$-order coupled implicit fractional differential equation with initial conditions, using Laplace transform method. The topological degree theory is used to obtain sufficient conditions for uniqueness and at least one solution of the considered system. Beside this, Ulam’s type stabilities are discussed for the proposed system. To support our main results, we present an example.
Economic Spill-Over of Food Quality Schemes on Their Territory
Authors: Donati Michele , Wilkinson Adam , Veneziani Mario , Antonioli Federico , Arfini Filippo , Bodini Antonio , Amilien Virginie , Csillag Peter , Ferrer-Pérez Hugo , Gkatsikos Alexandros , Gauvrit Lisa , Gil Chema , Hoàng Việt , Knutsen Steinnes Kamilla , Lilavanichakul Apichaya , Mattas Konstadinos , Napasintuwong Orachos , Nguyễn An , Nguyen Mai , Papadopoulos Ioannis , Ristic Bojan , Stojanovic Zaklina , Tomić Maksan Marina , Török Áron , Tsakiridou Efthimia , Bellassen Valentin
Published: November 2020

We study the effect of a set of food quality scheme (FQS) products within the local economy using a local multiplier approach based on LM3 methodology. To evaluate the effective contribution within the local area, we compare each FQS product with its equivalent standard/conventional counterpart. Local multiplier allows us to track the financial flows converging within the local area at the different levels of the supply chain so that we can measure the FQS product role in local economic activation. Overall, the FQS products exhibit a higher positive contribution to the local economy than the standard references. However, there is significant heterogeneity in the impact according to the product categories. In the case of vegetal products, the local economic advantage due to FQS is 7% higher than the reference products, but the statistical tests reject the null hypothesis that the medians are significantly different from zero. On the contrary, animal products exhibit a larger contribution of FQS than the standard counterparts (+24%). The PGI products (+25%) produce the major effect, while PDO products show a median difference lower (+6%). The organic and non-organic products seem to be substantially equivalent in terms of contribution to the local economy, due to the similarity in the downstream processing phase.
Antimalarial properties and preventive effects on mitochondrial dysfunction by extract and fractions of Phyllanthus amarus (Schum. and Thonn) in Plasmodium berghei-infected mice
Authors: Olanlokun John Oludele , Babarinde Cecilia Opeyemi , Olorunsogo Olufunso Olabode
Published: November 2020

Objectives

Broad spectrum antimalarial drugs without deleterious effects on mitochondria are scarce. It is in this regard that we investigated the potency of methanol extract and solvent fractions of Phyllanthus amarus on chloroquine-susceptible and resistant strains of Plasmodium berghei, toxicity and its consequential effects on mitochondrial permeability transition (mPT) pore opening.

Methods

Malaria was induced in male Swiss mice with susceptible (NK 65) strain, divided into groups (n=5) and treated with 100, 200 and 400 mg/kg of methanol extract, n-hexane, dichloromethane, ethylacetate and methanol fractions daily for seven days. Percentage parasitemia and parasite clearance were determined microscopically. The two most potent fractions were tested on resistant (ANKA) strains. Heme and hemozoin contents were determined spectrophotometrically. The mPT, mitochondrial ATPase (mATPase) and lipid peroxidation (mLPO) were determined spectrophotometrically. Similar groups of animals were used for toxicity studies.

Results

Dichloromethane fraction (400 mg/kg) had the highest antimalarial curative effect via least parasitemia (0.49) and high clearance (96.63) compared with the negative control (10.08, 0.00, respectively), had the highest heme and least hemozoin contents (16.23; 0.03) compared with the negative control (8.2, 0.126, respectively). Malaria infection opened the mPT, caused significant increase in mLPO and enhanced mATPase; while dichloromethane fraction reversed these conditions. Serum ALT, AST, ALP, GGT, urea and creatinine of dichloromethane fraction-treated mice decreased relative to control. No significant lesion was noticed in liver and kidney tissue sections.

Conclusions

Dichloromethane fraction of Phyllanthus amarus had the highest antimalarial activity with the highest mito-protective effect and it was well tolerated without toxic effects.
p53 upregulated mediator of apoptosis (Puma) deficiency increases survival of adult neural stem cells generated physiologically in the hippocampus, but does not protect stem cells generated in surplus after an excitotoxic lesion
Authors: Bunk Eva C. , König Hans-Georg , Prehn Jochen H.M. , Kirby Brian P.
Published: November 2020

Objectives

Neurogenesis occurs in the mammalian brain throughout adulthood and increases in response to metabolic, toxic or traumatic insults. To remove potentially superfluous or unwanted neural stem cells/neuronal progenitors, their rate of proliferation and differentiation is fine-tuned against their rate of apoptosis. Apoptosis requires the transcriptional and posttranslational activation of Bcl-2-homolgy domain 3 (BH3)-only proteins. Previously, we demonstrated that the BH3-only protein p53-upregulated mediator of apoptosis (Puma) controls the physiological rate of apoptosis of neural precursor cells in the adult mouse hippocampus. Puma’s role in controlling a lesion-induced increase in neural stem cells is currently not known.

Methods

We employed a model of local, N-methyl-D-asparte (NMDA)-induced excitotoxic injury to the CA1 hippocampal subfield and immunofluorescence labelling to produce increased neural stem cell proliferation/ neurogenesis in the dentate gyrus at two survival times following the excitotoxic lesion.

Results

Deletion of puma failed to rescue any NMDA-induced increase in adult born cells as assessed by BrdU or Doublecortin labelling in the long-term. No difference in the proportion of BrdU/NeuN-positive cells comparing the different genotypes and treatments suggested that the phenotypic fate of the cells was preserved regardless of the genotype and the treatment.

Conclusions

While neurogenesis is up-regulated in puma-deficient animals following NMDA-induced excitotoxicity to the hippocampal CA1 subfield, puma deficiency could not protect this surplus of newly generated cells from apoptotic cell death.
The Past as Prologue: Imagining a Brave New World in Philip Osment’sThis Island’s Mine
Authors: Urie Andrew
Published: November 2020

Employing an interdisciplinary sociopolitical framework, I examine Philip Osment’s playThis Island’s Mine(1988) and demonstrate how it interrogates and repudiates Margaret Thatcher’s neoconservative authoritarian populism. Specifically, I argue that Osment’s play constitutes not only a damning indictment of Thatcherism, but also an enduring work that speaks directly to our present sociopolitical conjuncture, which has witnessed varied forms of reactionary populism sweep nations throughout the international community.
The utility of 68Ga-DOTATATE PET/CT in localizing primary/metastatic pheochromocytoma and paraganglioma in children and adolescents – a single-center experience
Authors: Jaiswal Sanjeet Kumar , Sarathi Vijaya , Malhotra Gaurav , Hira Priya , Shah Ravikumar , Patil Virendra A. , Dalvi Abhay , Prakash Gagan , Lila Anurag R. , Shah Nalini S. , Bandgar Tushar
Published: November 2020

Objectives

Pediatric pheochromocytoma and paraganglioma (PPGL) are rare tumors with limited data on the diagnostic performance of 68Ga-DOTA(0)-Tyr(3)-octreotate positron emission tomography–computed tomography (68Ga-DOTATATE PET/CT). We have described our experience of 68Ga-DOTATATE PET/CT in overall and von Hippel Lindau (VHL)-associated pediatric PPGL and compared its sensitivity with that of 131I-meta-iodobenzyl-guanidine (131I-MIBG), 18F-fluorodeoxyglucose PET/CT (18F-FDG PET/CT), and contrast-enhanced CT (CECT).

Methods

Retrospective evaluation of consecutive PPGL patients (age: ≤20 years), who had undergone at least one functional imaging [131I-MIBG, 18F-FDG PET/CT, and/or 68Ga-DOTATATE PET/CT], was done. Composite of anatomical and all the performed functional imaging scans, image comparator (IC), was considered as the gold standard for sensitivity analysis.

Results

In a cohort of 32 patients (16 males, age at diagnosis: 16.4 ± 2.68 years), lesion-wise sensitivity of 68Ga-DOTATATE PET/CT (95%) was higher than that of both 18F-FDG-PET/CT (80%, p=0.027) and 131I-MIBG (65%, p=0.0004) for overall lesions, than that of 18F-FDG-PET/CT (100 vs. 67%, p=0.017) for primary PPG, and than that of 131I-MIBG (93 vs. 42%, p=0.0001) for metastases. In the VHL (n=14), subgroup, 68Ga-DOTATATE PET/CT had higher lesion-wise sensitivity (100%) compared to 18F-FDG PET/CT (74%, p=0.045) and 131I-MIBG (64%, p=0.0145).

Conclusions

In our pediatric PPGL cohort, overall lesion-wise sensitivity of 68Ga-DOTATATE PET/CT was higher than that of 18F–FDG PET/CT and 131I-MIBG scintigraphy. Hence, we recommend 68Ga-DOTATATE PET/CT as the preferred modality in pediatric PPGL. 68Ga-DOTATATE PET/CT may evolve as a preferred imaging modality for disease surveillance in VHL.
Serum level of NPTX1 is independent of serum MKRN3 in central precocious puberty
Authors: Jeong Hwal Rim , Yoon Jong Seo , Lee Hye Jin , Shim Yeong Suk , Kang Min Jae , Hwang Il Tae
Published: November 2020

Objectives

Makorin ring finger protein 3 (MKRN3) is associated with the initiation of puberty, and loss of function mutation of MKRN3 is the most common genetic cause of central precocious puberty (CPP). A recent study reported that MKRN3 interacts with and suppresses neural pentraxin-1 precursor (NPTX1) activity via polyubiquitination during early puberty in the mouse hypothalamus. This study investigated the correlation between serum NPTX1 and MKRN3 in CPP girls and predicted the potential role of NPTX1 in pubertal progression.

Methods

In this case–control study, we examined 34 girls diagnosed with CPP and 34 healthy prepubertal girls. Anthropometric and hormonal parameters were measured and serum levels of NPTX1 and MKRN3 were evaluated with commercial enzyme-linked immunosorbent assay kits.

Results

Serum MKRN3 level decreased significantly in CPP patients compared to controls (344.48 ± 333.77 and 1295.21 ± 780.80 pg/mL, respectively, p<0.001). Serum MKRN3 tended to decrease as Tanner breast stage increased. However, no significant difference was observed in serum NPTX1 levels between patients and controls (20.14 ± 31.75 ng/mL and 12.93 ± 8.28 ng/mL, respectively, p=0.248). The serum level of NPTX1 did not change significantly with the Tanner breast stage. Serum NPTX1 was correlated with the height standard deviation score (r=0.255; p<0.05), but was not correlated with serum MKRN3 level or the others. Conclusion: Although serum NPTX1 level was independent of serum MKRN3 level, the possibility they might be involved in the progression of puberty or CPP remains. Further research is needed to determine their role in the hypothalamus.
Defending Government Tort Litigation: Considerations for Scholars
Authors: Figley Paul
Published: November 2020

I am honored by the invitation to participate in this symposium on “What Practitioners Can Teach Academics About Tort Litigation” and to share my views from the defense side of government tort litigation. I have a foot in each camp of the practitioner/academic divide. For three decades I defended the federal government in Federal Tort Claims Act (FTCA) litigation, serving for the last 15 of those years as Deputy Director of the FTCA Staff in the Civil Division of the U.S. Department of Justice. I worked with the FTCA and its jurisprudence on a daily basis—litigating cases, assessing and negotiating proposed settlements, advising agencies and Assistant U.S. Attorneys, and commenting on proposed legislation. I left Justice in 2006 to become an academic, a role in which I have had the pleasure of teaching Torts to first year law students and the time and freedom to write about sovereign immunity, the FTCA, and other things.
Fighting the Good Fight: The Insurance Defense Litigator
Authors: Cummins Daniel E.
Published: November 2020

‘Fighting the good fight’ is how some insurance defense attorneys view their position in civil litigation law as they work towards reasonable resolutions of personal injury damages claims and take the frivolous cases all the way to verdict. This writer was requested to analyze the day-to-day practice of an insurance defense litigator in tort matters. The focus of the paper was to provide those in the legal academic field with insight into defense litigation in the tort arena of personal injury matters. This paper endeavors to provide that insight along with suggestions as to areas of training that law students may benefit from if offered in law school to prepare them for the practice of law.
Improved molecular laboratory productivity by consolidation of testing on the new random-access analyzer Alinity m
Authors: Obermeier Martin , Pacenti Monia , Ehret Robert , Onelia Francesco , Gunson Rory , Goldstein Emily , Chevaliez Stéphane , Vilas Alba , Glass Allison , Maree Leana , Krügel Maria , Knechten Heribert , Braun Patrick , Naeth Gudrun , Azzato Francesca , Lucic Danijela , Marlowe Natalia , Palm Michael John , Pfeifer Karin , Reinhardt Birgit , Dhein Jens , Joseph Ajith Mathew , Martínez-García Laura , Galán Juan-Carlos
Published: November 2020

Objectives

Automated molecular analyzers have accelerated diagnosis, allowing earlier intervention and better patient follow-up. A recently developed completely automated molecular analyzer, Alinity™ m (Abbott), offers consolidated, continuous, and random-access testing that may improve molecular laboratory workflow.

Methods

An international, multicenter study compared laboratory workflow metrics across various routine analyzers and Alinity m utilizing assays for human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV), hepatitis B virus (HBV), high-risk human papillomavirus (HR HPV), and sexually transmitted infection (STI) (Chlamydia trachomatis [CT]/Neisseria gonorrhoeae [NG]/Trichomonas vaginalis [TV]/Mycoplasma genitalium [MG]). Three turnaround times (TATs) were assessed: total TAT (sample arrival to result), sample onboard TAT (sample loading and test starting to result), and processing TAT (sample aspiration to result).

Results

Total TAT was reduced from days with routine analyzers to hours with Alinity m, independent of requested assays. Sample onboard TATs for standard workflow using routine analyzers ranged from 7 to 32.5 h compared to 2.75–6 h for Alinity m. The mean sample onboard TAT for STAT samples on Alinity m was 2.36 h (±0.19 h). Processing TATs for Alinity m were independent of the combination of assays, with 100% of results reported within 117 min.

Conclusions

The consolidated, continuous, random-access workflow of Alinity m reduces TATs across various assays and is expected to improve both laboratory operational efficiency and patient care.
Morphosyntactic predictability of translationese
Authors: Nikolaev Dmitry , Karidi Taelin , Kenneth Neta , Mitnik Veronika , Saeboe Lilja , Abend Omri
Published: November 2020

It is often assumed that translated texts are easier to process than original ones. However, it has also been shown that translated texts contain evident traces of source-language morphosyntax, which should presumably make them less predictable and harder to process. We test these competing observations by measuring morphosyntactic entropies of original and translated texts in several languages and show that there may exist a categorical distinction between translations made from structurally-similar languages (which are more predictable than original texts) and those made from structurally-divergent languages (which are often non-idiomatic, involve structural transfer, and therefore are more entropic).
On the equivalence of three-dimensional differential systems
Authors: Zhou Jian , Zhao Shiyin
Published: November 2020

In this paper, firstly, we study the structural form of reflective integral for a given system. Then the sufficient conditions are obtained to ensure there exists the reflective integral with these structured form for such system. Secondly, we discuss the necessary conditions for the equivalence of such systems and a general three-dimensional differential system. And then, we apply the obtained results to the study of the behavior of their periodic solutions when such systems are periodic systems in t.
A case report of cervical pregnancy after in vitro fertilization complicated by tuberculosis and a literature review
Authors: Liu Kun , Zhang Xuehong , Ma Xiaoling , Jia Xueling , Zhao Xiaodong , Yang Xia , Zhang Yufeng
Published: November 2020

Although female genital tuberculosis may lead to infertility, pregnancy is still possible, especially through in vitro fertilization (IVF). In this eventuality, even latent tuberculosis (TB) infection is prone to reactivate. Because some of the symptoms of TB overlap with those of pregnancy, diagnosis and treatment may be delayed. We report the case of a 30-year-old infertile woman with repeated genital tuberculosis (GTB) who underwent two laparoscopic surgeries and anti-TB treatments. The woman conceived through IVF and, unfortunately, a cervical pregnancy was diagnosed, together with a third recurrence of GTB. When the condition became stable after anti-TB treatment, the pregnancy was terminated using oral mifepristone in combination with an ultrasound-guided local injection of methotrexate. The gestational sac was expelled 4 days later with minimal blood loss. In view of the reciprocal influence and interconnection between IVF, pregnancy, and TB, we conducted a literature review to provide valuable information for early diagnosis and treatment, as well as for routine screening before IVF of TB in infertile patients.
Transzendenz berühren. Die (halbe) Kerze als Schnittstelle zwischen Transzendenz und Immanenz im Marienmirakel ‚Erscheinung am Lichtmesstage‘ des ‚Passionals‘
Authors: Gerber Jennifer
Published: November 2020

The miracle play ‘Erscheinung am Lichtmesstage’ of the late medieval ‘Passional’ offers a literary interpretation of the ‘Candlemas’ and its procession with lighted candles. After a woman has been enraptured into transcendent space, she partakes in a light procession together with the Virgin Mary and various other figures. Each of the participants carries a candle, whose light, as the text says, is sacrificed at the end of the procession. One candle, however, becomes subject of a dispute between the woman and a messenger from the Virgin Mary, causing the candle to split in two. The text repeatedly addresses the actual touching of the candle, suggesting that this wax artefact plays an essential role in bridging the immanent and transcendent. This article explores the candle as a ‘Semiophore’, revealing the broad semantic spectrum of the candle and its light. Through the acts of giving, holding, depositing, seizing, pulling, braking, and touching as well as possessing and keeping the candle become the locus of multiple meanings. Ultimately, it functions as a bridge between the ordinary and the divine.
Dazzle, Dangle, and Jangle: Sensory Effects of Scandinavian Gold Bracteates
Authors: Wicker Nancy L.
Published: November 2020

Small pendant discs known as Scandinavian gold bracteates are visually impressive indicators of status and identity during the early medieval Migration Period (c. 450–550 CE). Much of the emphasis in bracteate studies has been on typological classification and iconographic interpretation of the pictures, along with decipherment of the inscriptions, yet the sensory impression made by bracteates has been neglected. For decades, archaeologists considered it futile to speculate on the experiential; however, recent research has begun to contend with the materiality of senses and emotions in the past. In this paper, I focus on the both sensory effect of experiencing the pendants and the emotional impact of the objects on those who wore and handled them. Since bracteates are often discovered in women’s graves and show evidence of wear on their suspension loops, it is assumed that these objects were actually used in life. A spotlight on agency turns the study of bracteates from an emphasis on typology, iconography, and runology to trace instead the agency and multisensory effects of these objects on people and the effects of people’s actions on these items. This allows an examination of how bracteates were entangled with the senses and emotions of those who made, wore, and gazed upon these small but important objects. I consider what it may have felt like to make, receive, wear, lose, or bequeath a bracteate – or to deposit it into a bog or a grave.
Beyond Porn and Discreditation: Epistemic Promises and Perils of Deepfake Technology in Digital Lifeworlds
Authors: Kerner Catherine , Risse Mathias
Published: November 2020

Deepfakes are a new form of synthetic media that broke upon the world in 2017. Bringing photoshopping to video, deepfakes replace people in existing videos with someone else’s likeness. Currently most of their reach is limited to pornography, and they are also used to discredit people. However, deepfake technology has many epistemic promises and perils, which concern how we fare as knowers. Our goal is to help set an agenda around these matters, to make sure this technology can help realize epistemic rights and epistemic justice and unleash human creativity, rather than inflict epistemic wrongs of any sort. Our project is exploratory in nature, and we do not aim to offer conclusive answers at this early stage. There is a need to remain vigilant to make sure the downsides do not outweigh the upsides, and that will be a tall order.