bluuebunny/crossref_metadata_2025 huggingface dataset:
Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes
Authors: Chen Min , Ohm Daniel T. , Phillips Jeffrey S. , McMillan Corey T. , Capp Noah , Peterson Claire , Xie Emily , Wolk David A. , Trojanowski John Q. , Lee Edward B. , Gee James , Grossman Murray , Irwin David J.
Published: March 2022

Network analyses inform complex systems such as human brain connectivity, but this approach is seldom applied to gold-standard histopathology. Here, we use two complimentary computational approaches to model microscopic progression of the main subtypes of tauopathy versus TDP-43 proteinopathy in the human brain. Digital histopathology measures were obtained in up to 13 gray matter (GM) and adjacent white matter (WM) cortical brain regions sampled from 53 tauopathy and 66 TDP-43 proteinopathy autopsy patients. First, we constructed a weighted non-directed graph for each group, where nodes are defined as GM and WM regions sampled and edges in the graph are weighted using the group-level Pearson's correlation coefficient for each pairwise node comparison. Additionally, we performed mediation analyses to test mediation effects of WM pathology between anterior frontotemporal and posterior parietal GM nodes. We find greater correlation (i.e., edges) between GM and WM node pairs in tauopathies compared with TDP-43 proteinopathies. Moreover, WM pathology strongly correlated with a graph metric of pathology spread (i.e., node-strength) in tauopathies (r= 0.60,p< 0.03) but not in TDP-43 proteinopathies (r= 0.03,p= 0.9). Finally, we found mediation effects for WM pathology on the association between anterior and posterior GM pathology in FTLD-Tau but not in FTLD-TDP. These data suggest distinct tau and TDP-43 proteinopathies may have divergent patterns of cellular propagation in GM and WM. More specifically, axonal spread may be more influential in FTLD-Tau progression. Network analyses of digital histopathological measurements can inform models of disease progression of cellular degeneration in the human brain.

SIGNIFICANCE STATEMENTIn this study, we uniquely perform two complimentary computational approaches to model and contrast microscopic disease progression between common frontotemporal lobar degeneration (FTLD) proteinopathy subtypes with similar clinical syndromes during life. Our models suggest white matter (WM) pathology influences cortical spread of disease in tauopathies that is less evident in TDP-43 proteinopathies. These data support the hypothesis that there are neuropathologic signatures of cellular degeneration within neurocognitive networks for specific protienopathies. These distinctive patterns of cellular pathology can guide future efforts to develop tissue-sensitive imaging and biological markers with diagnostic and prognostic utility for FTLD. Moreover, our novel computational approach can be used in future work to model various neurodegenerative disorders with mixed proteinopathy within the human brain connectome.
BUSINESS PLANNING TRAINING PROGRAM TO DEVELOP ENTREPRENEURIAL INTERESTS OF THE YOUNGER GENERATION IN TEGALSARI VILLAGE OF TEGALSARI CITY
Authors: Habibi Beni , Apriani Dewi , Yulianto A. Rony
Published: March 2022

A step is needed to build entrepreneurial interests of the younger generation, one of which is to create a program that accommodates the aspirations of generations to increase their business interests, namely through entrepreneurial training programs. Business planning training program for the younger generation is done in Tegalsari Village, Tegalsari. This business planning training program aims to increase entrepreneurial interest for young people and guide the business preparation process ranging from the introduction of types of businesses to the preparation of businesses through examples of businesses made by participants. Based on the results of the training activities that have been carried out, it can be drawn as follows. Participants' knowledge of entrepreneurship is very strong as seen from pre-test and post-test results. This result is quite proud because most participants are participants who have received entrepreneurial counseling in the previous year. The delivery of knowledge about the preparation of business planning can improve the knowledge and understanding of participants about the objectives and benefits and the importance of making business planning before deciding to be entrepreneurial

Diperlukan sebuah langkah untuk membangun minat berwirausaha para generasi muda yaitu salah satunya dengan membuat sebuah program yang menampung aspirasi para generasi untuk meningkatkan minat usahanya yaitu melalui program pelatihan kewirausahaa. Program pelatihan perencanaan usaha untuk generasi muda ini di lakukan di kelurahan Tegalsari Kota Tegal. Program pelatihan perencanaan usaha ini bertujuan untuk meningkatkan minat wirausaha bagi kalangan muda dan membimbing proses penyusunan usaha mulai dari pengenalan jenis â€“ jenis usaha sampai dengan menyusun usaha melalui contoh usaha yang dibuat oleh peserta. Berdasarkan hasil pelaksanaan kegiatan pelatihan yang telah dilakukan, dapat ditarik simpulan sebagai berikut. Pengetahuan peserta mengenai kewirausahaan tergolong sangat kuat yang terlihat dari hasil pre-test dan post-test. Hasil ini cukup membanggakan karena sebagian besar peserta adalah peserta yang telah mendapatkan penyuluhan kewirausahaan pada tahun sebelumnya. Penyampaian pengetahuan tentang penyusunan perencanaan usaha dapat meningkatkan pengetahuan dan pemahaman peserta mengenai tujuan dan manfaatnya serta pentingnya membuat perencanaan usaha sebelum memutuskan berwirausaha.
RAISING AWARENESS OF VILLAGE ARCHIVES ORDERLY THROUGH RECORD MANAGEMENT ASSISTANCE PROGRAM BASED ON SIMULATION VIDEO
Authors: Ismiyati Ismiyati , Pramusinto Hengky , Marimin Marimin , Handayani Bestari Dwi , Sholikah Mar'atus
Published: March 2022

Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan aparatur desa dan meningkatkan kesadaran akan pentingnya tertib arsip di Desa Kenteng. Upaya meningkatkan keterampilan dan kesadaran aparat desa dalam mengelola arsip sesuai kaidah yang berlaku dilakukan melalui pendampingan teknis penataan arsip sesuai kaidah kearsipan di lingkungan pemerintahan. Hasil dari kegiatan masyarakat ini menunjukkan partisipasi peserta sangat tinggi dalam kegiatan webinar record management. Kegiatan webinar berkaitan dengan teknik penataan arsip. Kegiatan webinar dimaksudkan sebagai pengganti kegiatan sosialisasi secara langsung, karena masa pandemi COVID-19 mengharuskan segala bentuk kegiatan tatap muka dikurangi. Untuk itu, kegiatan pengabdian dilakukan dengan acara webinar. Setelah diberikan webinar, dilanjutkan dengan pendampingan teknis kearsipan dengan cara simulation video di lapangan tentang penataan kembali arsip sesuai klasifikasi yang ada, dengan tujuan agar aparatur desa tertib akan arsip. Selain itu, arsip yang dibutuhkan dapat mudah ditemukan kembali. Evaluasi kegiatan webinar dan pendampingan penataan arsip ini menunjukkan bahwa seluruh aparatur desa menunjukkan peningkatan dalam kemampuan dan kesadaran terhadap tertib arsip desa.

The purpose of this community service activity is to increase the knowledge of village apparatus and raise awareness of the importance of orderly archives in Kenteng Village. Efforts to improve the skills and awareness of village officials in managing archives in accordance with applicable rules are carried out through technical assistance in the arrangement of archives in accordance with archival rules in the government environment. The results of this community activity showed very high participation of participants in record management webinar activities. Webinar activities related to archival structuring techniques. Webinar activities are intended as a substitute for direct socialization activities, as the COVID-19 pandemic requires all forms of face-to-face activities to be reduced. Therefore, devotional activities are carried out with webinar events. After being given a webinar, followed by archival technical assistance by means of simulation video in the field about the rearranging of archives according to existing classifications, with the aim of orderly village apparatus will archive. In addition, the required archives can be easily rediscovered. Evaluation of webinar activities and assistance in the arrangement of this archive shows that all village apparatus shows improvement in the ability and awareness of the orderly village archives.
Impact of GH administration on skeletal endpoints in adults with overweight/obesity
Authors: Dichtel Laura E , Haines Melanie S , Gerweck Anu V , Bollinger Bryan , Kimball Allison , Schoenfeld David , Bredella Miriam A , Miller Karen K
Published: March 2022

Objective

Overweight/obesity is associated with relative growth hormone (GH) deficiency and increased fracture risk. We hypothesized that GH administration would improve bone endpoints in individuals with overweight/obesity.

Design

An 18-month, randomized, double-blind, placebo-controlled study of GH, followed by 6-month observation.

Methods

In this study, 77 adults (53% men), aged 18–65 years, BMI ≥ 25 kg/m2, and BMD T- or Z-score ≤ −1.0 were randomized to daily subcutaneous GH or placebo, targeting IGF1 in the upper quartile of the age-appropriate normal range. Forty-nine completed 18 months. DXA, volumetric quantitative CT, and high-resolution peripheral quantitative CT were performed.

Results

Pre-treatment mean age (48 ± 12 years), BMI (33.1 ± 5.7 kg/m2), and BMD were similar between groups. P1NP, osteocalcin, and CTX increased (P < 0.005) and visceral adipose tissue decreased (P = 0.04) at 18 months in the GH vs placebo group. Hip and radius aBMD, spine and tibial vBMD, tibial cortical thickness, and radial and tibial failure load decreased in the GH vs placebo group (P < 0.05). Between 18 and 24 months (post-treatment observation period), radius aBMD and tibia cortical thickness increased in the GH vs placebo group. At 24 months, there were no differences between the GH and placebo groups in bone density, structure, or strength compared to baseline.

Conclusions

GH administration for 18 months increased bone turnover in adults with overweight/obesity. It also decreased some measures of BMD, bone microarchitecture, and bone strength, which all returned to pre-treatment levels 6 months post-therapy. Whether GH administration increases BMD with longer treatment duration, or after mineralization of an expanded remodeling space post-treatment, requires further investigation.
Género, empoderamiento y complejidad: un conflicto de la mujer en el contexto de la modernidad
Authors: Madero Zambrano Kendy , Del Toro Rubio Moraima , Vallejo Arias Sandra Lorena
Published: March 2022

El rol femenino suele ser estereotipado, sin embargo, con el paso del tiempo la mujer ha adquirido progresivamente mayor empoderamiento y protagonismo en la sociedad, lo que ha permitido el desempeño de diversos roles al tiempo, tales como, estudiante, trabajadora, madre y cónyuge. El objetivo del estudio es identificar la percepción de mujeres frente a la multiplicidad de roles y su impacto social en la actualidad. Se realizó un estudio cualitativo, fenomenológico y hermenéutico, con una población de 19 estudiantes. Se aplicaron entrevistas semiestructurada sobre aspectos sociodemográficos y experiencias de las estudiantes en sus roles. La experiencia de sus roles fueron calificadas como duras, complejas, difíciles y le atribuyen significado de responsabilidad, compromiso, sacrificio. Se encontró que prevalecieron los sentimientos de dolor, tristeza y frustración. La sensación que más experimentan es la satisfacción y el empoderamiento; y percibieron muy escaso su tiempo. Las experiencias de las mujeres en el ejercicio de los roles, resultaron complejos y cargados de sentimientos encontrados y efectos históricamente marcados por el género, sin embargo, la satisfacción que genera en su crecimiento personal prevalece. No obstante, en el imaginario de las mujeres la repercusión social que esto genera recae en el descuido de la crianza de sus hijos.
Ámbitos de justificación biográfica de la decisión de no tener hijos
Authors: Rojas Betancur Hector Mauricio , Hernández Quirama Andrea
Published: March 2022

Se analizan, desde rutas biográficas de adultos que han decidido no tener hijos y no ejercer roles de maternidad o paternidad, los dispositivos de justificación en el contexto de la sobrepoblación y la responsabilidad ambiental. Se realizó un estudio cualitativo, fenomenológico con entrevistas en profundidad a personas adultas, residentes en distintas ciudades de Colombia, que decidieron no ser madres o no ser padres. Se concluye que la decisión de no tener hijos es una especie de fractura biográfica que transgrede los preceptos sociales sobre la reproducción y como el tema de la superpoblación y la crisis ambiental, es el mejor contexto social de legitimación de las decisiones sobre la no reproducción.
Las cinco vías y la “verdad fundamental” de la Metafísica tomista
Authors: Miró i Comas Abel
Published: March 2022

La Metafísica es la ciencia que estudia el ente en cuanto ente; toda realidad, bajo su prisma, es contemplada según su relación con el acto de esse. La noción de ente es, a su vez, el punto de apoyo que le permite ascender hasta Dios (Ente por esencia) y, desde Él, descender hasta las criaturas (entes por participación). En el presente estudio nos preguntamos por el punto de partida del punto de partida de la Metafísica entendida como Ontología: ¿de dónde sale la noción metafísica de ente?, ¿cuál es su vínculo con la experiencia del hombre ordinario? El conocimiento del ente y, por lo tanto, de su constitutivo formal, que es el esse, ya está presupuesto, aunque de un modo confuso, implícito, en la experiencia cotidiana del hombre; la noción metafísica de ente es la explicitación de un conocimiento en el que el hombre ya se encuentra connaturalmente instalado. La tesis que defendemos aquí, siguiendo a Fray Norberto del Prado, O. P., es que el tránsito de este conocimiento latente del ente como primum cognitum a su explicitación científica, en la noción de ente como terminus metaphysicalis, se realiza a través de las cinco vías de Santo Tomás (Summa Theologiae, I, q.2, a.3). En cada una de las vías, desde su mismo punto de arranque, ya está presente —aunque subterráneamente— la tesis de la composición acto-potencial de los seres creados entre essentia y esse y, por consiguiente, un cierto conocimiento del ente y del misterio del esse. En nuestro estudio, vamos a poner de manifiesto cómo esta tesis —que, junto con la identidad entre essentia y esse en la Causa Primera, constituye lo que Norberto del prado llama la “verdad fundamental de la filosofía cristiana”— ya está ejerciendo su influjo en las cinco vías. Por último, a modo de conclusión, expondremos de qué modo las cinco vías se condensan en la cuarta, y cómo a través de ella —que ya está presupuesta en el punto de partida de todas las demás— se realiza el tránsito del conocimiento ordinario del hombre a la noción científica de ente.
World global demining problem: Ukrainian vector
Authors:   National Academy of Sciences of Ukraine, Kyiv, Ukraine, Horbulin Volodymyr
Published: March 2022

The global problem of demining with a projection on Ukraine is actualized. The place and role of mine weapons in modern low-intensity wars, including the hybrid war against Ukraine, are highlighted. The consequences and problematic issues of mine wars for the world and Ukraine are considered on a systematic basis. The situation with the development of mine detection tools in other countries is analyzed. A multi-subject analysis of the situation related to the demining of Ukrainian territories is conducted, and conclusions were made about its current state. The importance of developing research in Ukraine aimed at creating the latest means of detecting explosive devices is emphasized.
Systemic risks in an unstable society: Social and cultural-informational dimensions
Authors:   Institute of Sociology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine, Skokova Lyudmyla
Published: March 2022

The article presents the main results of research work at the Institute of Sociology of the National Academy of Sciences of Ukraine. It is emphasized that the instability of social processes in the global context is associated with systemic risks of exogenous and endogenous nature, in turn, states of instability and crises (economic, financial, political, coronavirus, etc.) provoke the deployment and layering of systemic risks in different spheres of public life. Sociological interpretation of systemic risks involves attention to the specifics of the functioning of social institutions, the characteristics of socio-psychological and cultural-information climate, the direction of attitudes and practices of citizens. Based on a generalized vision of theoretical and methodological approaches to the study of risks, analysis of empirical data from opinion polls (monitoring "Ukrainian Society" Institute of Sociology of NAS of Ukraine and other data) sociological analysis of manifestations and localizations of systemic risks of poverty, social tension, education and employment, e-democratization, leisure participation, digital media is carried out.
Material Aspects of Building and Craft Traditions
Authors: Feiglstorfer Hubert
Published: March 2022

The manual production of objects and buildings significantly shapes the material culture of societies. Knowledge concerning the ideal properties of materials obtained from nature, techniques of processing raw materials, and the skills needed to manufacture certain products have been passed down from generation to generation over the centuries. Many buildings, as well as objects in daily use, which we consider cultural heritage today, have their origin in the skills of crafts(wo)men and the craft traditions to which they belong. In contrast to workers in the industrial prefabrication of products, crafts(wo)men have to be able to react flexibly to different natural conditions. The properties of naturally occurring raw materials such as clay, stone or wood can vary greatly. Crafts(wo)men must constantly draw upon and adapt the knowledge, skills and techniques they have learned in order to optimize the quality of their products. The author of this book is an architect and architectural historian, which is why his research makes strong reference to craft traditions in construction. In addition, he researches building materials, their properties and processing methods, with a focus on clay and clay building techniques. Bringing these main research areas together enables the observation of building craft traditions from different perspectives. The social status of materials and processing methods can differ greatly between societies. This book focuses on Buddhist architecture in the Himalayas, where the author has been conducting research for over 20 years. Certain behavioral patterns, such as ritually walking around the perimeter of religious buildings and objects, reinforce their symbolic value in the respective community. These meanings, in turn, are made tangible through certain materials, shapes, colors, or textures used in the buildings themselves. In the course of the research, it became clear that particular traditional processing methods can be found in various craft disciplines. For example, the method of polishing roofs or walls is used in the manufacture of certain religious objects such as clay sculptures, and also in the manufacture of everyday objects such as clay ovens or pottery. Traditional knowledge about such processing methods is spread over large parts of the Himalayas and is regionally adapted to the respective crafts. The Himalayan region is ideal for this research due to its diverse natural conditions. Different altitudes, topographies, vegetation, climatic and geological conditions have shaped building and handicraft traditions across this region. This book clearly shows connections between natural conditions and regional building and craft traditions, as well as their combined influence on material culture in the Himalayas.
"A Lidl und a Tanc" oder "There's no Business like Showbusiness"
Authors: Berg Klaus
Published: March 2022

Ein unaufgeschnittenes Exemplar von Emanuel Ringelblums "Kronika Getta Warszawskiego", ergänzt um Besprechungen und Theater-Anzeigen der Ghettozeitung "Gazeta Żydowska" ließ das unglaubliche Bild gefeierter Theater-Aufführungen und großer Publikumserfolge im Warschauer Ghetto erstehen. Auf Basis dieser hier erstmals ins Deutsche übersetzten Quellen legt Klaus Berg eine nahezu vollständige Dokumentation über die Theater im Warschauer Ghetto vor, die eine Würdigung der Künstler/innen erlaubt und für die weitere Forschung, ebenso wie für populärwissenschaftliche Darstellungen, wegweisend sein dürfte.
PENERAPAN MODEL COOPERATIVE LEARNING TIPE BAMBOO DANCING TERHADAP KEMAMPUAN KOGNITIF MATEMATIKA SISWA
Authors: Halawati Firda , Saepudin Aep
Published: March 2022

Tujuan penelitian ini untuk: mengetahui penerapan tipe bamboo dancing, untuk mengetahui kemampuan kognitif matematika siswa; untuk mengetahui penerapan tipe bamboo dancing terhadap kemampuan kognitif matematika. Penelitian ini menggunakan quasi eksperimental design. Dalam pengambilan sampel menggunakan teknik purposive sampling. Penelitian menggunakan dua kelas yaitu IVA sebanyak 22 siswa sebagai kelas eksperimen dan IVB sebanyak 27 siswa sebagai kelas kontrol. Instrumen penelitian berupa soal tes pilihan ganda. Soal tes diberikan pada tes awal (pretest) dan soal tes akhir (posttest). Sebelum soal tes diberikan diuji terlebih dahulu instrumen tes berupa, uji validitas, uji reliabilitas, tingkat kesulitan soal, dan daya pembeda soal dianalisis terlebih dahulu. Analisis data pengujian hipotesis dalam penelitian ini menggunakan Independent Samples T-Test yang sebelumnya telah diuji untuk normalitas dan homogenitas. Hasil penelitian ini menunjukkan bahwa (1) Penerapan tipe bamboo dancing berjalan dengan baik dan efektif hal ini dapat dilihat dari hasil kenaikan rata-rata kelas eksperimen yang menggunakan tipe bamboo dancing (2) Data hasil tes awal dan tes akhir dari kedua kelas tersebut dianalisis, diperoleh hasil rata-rata tes awal (pretest) kelas eksperimen sebesar 54,55 dan tes akhir (postest) sebesar 87,14 sehingga terdapat kenaikan sebesar 59,74%. Sedangkan rata-rata tes awal (pretest) kelas kontrol sebesar 53,33 dan tes akhir (postest) sebesar 72,19 sehingga terdapat kenaikan sebesar 35,36%. Hal ini diperkuat dengan uji perbedaan rata-rata (Uji-t) yang diperoleh  >  yaitu 5,324>1,678 dan nilai signifikannya dibawah 0,05 yaitu 0,00<0,05. Berdasarkan uji N-Gain diperoleh nilai N-Gain kelas eksperimen sebesar 0,72 yang berkriteria tinggi dan kelas kontrol sebesar 0,51 yang berkriteria sedang. (3) Berdasarkan hasil ini menunjukkan bahwa Ha diterima dan Ho ditolak maka dapat disimpulkan terdapat pengaruh penggunaan  tipe bamboo dancing terhadap kemampuan kognitif matematika.
ANALISIS KENDALA SISTEM BELAJAR DARING TERHADAP PEMBELAJARAN MATEMATIKA DI KAMPUS
Authors: Niani Cukri Rahmi , Rahma Cukri
Published: March 2022

Wabah Covid-19 yang telah menyebar hampir ke seluruh wilayah Indonesia memaksa kita untuk melakukan segala akitivitas dari rumah termasuk kegiatan belajar mengajar di sekolah atau kampus. Pemerintah telah menetapkan bahwa proses belajar mengajar harus dilakukan dari rumah (daring) selama masa pandemi covid-19. Selama proses pembelajaran daring dilaksanakan, banyak kendala yang dihadapi baik dari pihak dosen maupun mahasiswa. Penelitian ini dilakukan untuk mengetahui kendala sistem belajar daring yang mempengaruhi proses pembelajaran matematika pada mahasiswa. Kendala yang dilihat meliputi kendala kuota internet, kendala keluarga, kendala jaringan, kendala fasilitas Hp/Lattop dan kendala materi pembelajaran.Teknik pengumpulan data menggunakan data primer berupa kuesioner. Pemecahan masalah menggunakan teknik analisis regresi linier berganda. Berdasarkan hasil penelitian diperoleh model regresinya . Dapat disimpulkan bahwa kendala kuota internet (x2)  mempeunyai hubungan sebesar 24%  dengan pembelajaran matematika, selanjutnya keluarga (x3) memiliki hubungan 23%, jaringan internet (x1) sebesar 19%, fasilitas Hp/Lattop (x5)  14% dan meteri pembelajaran (x4) sebesar 8%.
KEMAMPUAN REPRESENTASI MATEMATIS PESERTA DIDIK PADA MATERI RELASI DAN FUNGSI DI KELAS VIII B SMP DARUL ULUM SEKAMPUNG
Authors: Merliza Pika
Published: March 2022

Kemampuan representasi matematis merupakan salah satu kemampuan yang harus dikuasai peserta didik di era digital karena berkaitan dengan kemampuan komunikasi dan pemecahan masalah. Untuk itu dibutuhkan penelitian yang bertujuan untuk mendeskripsikan kemampuan representasi peserta didik pada materi relasi dan fungsi pada peserta didik di kelas VIII B di SMP Darul Ulum Sekampung. Jenis penelitian yakni deskriptif, dengan subjek penelitian berjumlah 23 peserta didik kelas VII B. Teknik pengumpulan data dengan tes dan wawancara. Berdasarkan hasil penelitian, diketahui bahwa kemampuan representasi matematis peserta didik sudah dalam kategori baik, dimana kemampuan representasi visual dalam kategori baik sedangkan kemampuan representasi verbal masih dalam kategori sedang.
KEMAMPUAN BERPIKIR KREATIF MATEMATIS SISWA SMP DALAM MENYELESAIKAN SOAL PROBLEM POSING
Authors: Aba Maria Martini , Rukman Nia Kurniaty , Fatmawati Agustin
Published: March 2022

The Ministry of Education and Culture (2016) states that one of the learning objectives in the 2013 curriculum is to develop creative activities that involve imagination, intuition, and discovery by developing divergent, original thinking, curiosity, making predictions and guesses, and experimenting. The fact that the creative thinking ability of Indonesian students is still low is shown in the results of the Program for International Student Assessment (PISA) in mathematical ability, placing Indonesia at 62 out of 70 countries (OECD, 2016). The provision of problem-posing model questions is expected to stimulate students to think creatively by generating new ideas or ideas to develop existing information and finally students begin to propose new problems according to their understanding of the mathematical concepts being studied. The purpose of this study was to describe students' mathematical creative thinking ability seen from the indicators of creative thinking abilities, namely fluency, flexibility and novelty in solving problem posing question. The research method used is a survey method with the research subject being class VIIIG SMPN 1 Malang. The results obtained, the average score of the fluency indicator is 14.81 or 87.10% in the high category, the average score of the flexibility indicator is 4.64 or 51.61% in the low category, and the novelty indicator is 1.16 or 6, 45% with low category. This shows that the creative thinking ability of students in solving problem-posing questions is low.
Current approaches to screening for cervical cancer
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Burka O.A. ,   MC DILA, Kyiv, Tutchenko T.M. ,   SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine», Kyiv,   MC DILA, Kyiv
Published: March 2022

Considering the significant changes in approaches to the prevention of cervical cancer that have taken place over the past decades, the article considers the concept of primary, secondary and tertiary levels of preventive measures on cancer pathology in general, the nature and purpose of screening studies, the requirements to diagnostic tests that can be used as a screening. The modern approaches to cervical screening as a key component of secondary prevention of cervical cancer, the features of existing screening programs based on the initial determination of highly oncogenic strains of human papillomavirus virus alone and in combination with cytological research are considered in detail. Key words: cervical cancer, dysplasia, cervical intraepithelial neoplasia, human papillomavirus, screening.
Using the ERAS program in the work of the perinatal center for safe planned surgical treatment of primary progressive chronic venous disease during pregnancy
Authors:   CNE Regional Perinatal Center of the Rivne Regional Council, Аntonyuk-Кysil V. , Dziubanovskyi I. ,   State Pedagogical University Ternopil State Medical University named after Gorbachevsky, Yenikeeva V. ,   CNE Regional Perinatal Center of the Rivne Regional Council, Lichner S. ,   CNE Regional Perinatal Center of the Rivne Regional Council, Lypnyi V. ,   CNE Regional Perinatal Center of the Rivne Regional Council
Published: March 2022

The article presents 457 pregnant women’s planned surgical treatment results in the 2nd and 3rd trimesters with primary progressive chronic venous disease (CVD) C2-4s, Ep, As, p, Pr (according to CEAR 2002 classification) according to the ERAS program. As a result of the study, it was noted that the use of the ERAS’ ideology for the pregnant women planned surgical treatment with CVD required the implementation in general and in some of its components adaptation to these patients, scrupulous compliance with them at all stages (before, during and after) surgery. The most important in this program is a multidisciplinary approach to treating pregnant women, their hospitalization in a specialized obstetric hospital on the day of surgery, the use of perinatal psychotherapy for preparing the pregnant woman and the fetus before surgery, performing surgical interventions by a vascular surgeon so-called mono technologist or obstetric vascular surgeon. These factors contributed to the clinical 97% effectiveness achievement elective surgical treatment with 100% absence of all postoperative complications for the fetus and mother, prevented premature birth, helped to reduce the number and severity of postoperative complications from postoperative wounds that did not require additional treatment, did not affect fetal development, pregnancy course; ensured the childbirth and the postpartum period safety; comfortable pregnancy in the postoperative period with a decrease in the hospital stay length with the fastest possible patient’s return of the patient to their daily lifestyle was formed. All operated patients did not need medical support in the postoperative and postpartum periods, except for the use of elastic knitwear with compression class 2 (stockings or socks) during physical activity. Key words: non-obsessive-compulsive disorder, ERAS program, non-obstetric scheduled surgical treatment.
HELLP-syndrome: a modern look at the problem
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Zhabitskaya L.A.
Published: March 2022

The article presents a comprehensive analysis of modern data on severe disorder of pregnancy – HELLP-syndrome. New data on the prevalence, risk factors and pathogenesis of this pathology are presented, clinical symptoms and diagnostic criteria are described. The systematization of the results of recent studies has made it possible to formulate the features of differential diagnosis of HELLP-syndrome with so-called imitators of this pathology. According to the latest recommendations of FIGO and the main clinical guidlines, management of pregnant women with HELLP-syndrome are given. There are also recommendations for platelet transfusion (with/without other blood products) based on the platelet count, delivery method, active bleeding and coagulopathy. Key words: HELLP-syndrome, diagnostic criteria, treatment.
Modern aspects of bacterial vaginosis and medical tactics
Authors:   Donetsk National Medical University, Liman, Ayzyatulov R.F. , Ayzyatulova E.M. ,   Donetsk National Medical University, Liman
Published: March 2022

The objective: find out some etiopathogenetic aspects of bacterial vaginosis and develop optimal treatment methods to preserve the active reproductive potential of women. Materials and methods. The diagnosis of bacterial vaginosis was made on the basis of data from clinical and laboratory research methods. The following criteria were taken into account: homogeneous vaginal discharge, increased pH of the contents of the vagina, positively modified test, key cells in smears. Conducted microscopy of the contents of the vagina, aminotest, pH of the contents of the vagina, microbiological examination. Results. In making a diagnosis, along with the symptoms of the disease, microbiological research methods play a leading role. Modern approaches to the treatment of patients with bacterial vaginosis, currently considered as a violation of the microecology of the vagina, are somewhat different from those in the treatment of patients with urogenital infections. For complete treatment, it is necessary to identify microorganisms that are involved in the formation of bacterial vaginosis. Of particular difficulty is the treatment of bacterial vaginosis when combined with sexually transmitted infections, which requires antibiotic therapy, which further enhances the process of vaginal dysbiosis. Conclusion. Bacterial vaginosis is a violation of the vaginal ecosystem, requires timely diagnosis, adequate therapy and preventive measures. It is necessary to identify and eliminate endogenous or exogenous factors leading to changes in the vaginal ecosystem. Key words: bacterial vaginosis, etiology, pathogenesis, diagnosis, clinic, treatment.
Thrombophilia and obstetric complications
Authors:   Zhytomyr Medical Institute, Zabolotnov V.A. , Khvatova O.O. ,   Zhytomyr Medical Institute, Sehedina Y.P. ,   Zhytomyr Medical Institute
Published: March 2022

This article discusses the relationship of thrombophilia with obstetric complications. In women with habitual miscarriage, do not perform screening for hereditary thrombophilia. With habitual miscarriage, women should undergo screening before pregnancy to detect antiphospholipid antibodies. Positive screening results are an indication for the appointment of LMWH and aspirin. Women with IVF do not investigate for hereditary thrombophilia and do not do LMWH therapy. Do not perform an assessment of congenital thrombophilia in women with miscarriage, with a history of childbirth with FGR, pre-eclampsia and premature detachment of the normally located placenta. Key words: thrombophilia, antiphospholipid syndrome, obstetric complications, miscarriage.
Features of course of pregnancy, labors and functional condition of fetoplacental complex a t women with the combined pathology of uterus and mammary glands
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kiev, Polyulyakh O.A.
Published: March 2022

The objective: to study features of a course of pregnancy, labors and a functional condition of fetoplacental complex at women with the combined pathology of uterus and mammary glands. Materials and methods. It was carried out complex clinical-laboratory and functional inspection 120 women who depending on existence of benign pathology of mammary glands and were parted on corresponding at groups and subgroups. In complex of the conducted researches were included clinical, ekhografical, dopplerometrical, cardiotocografical, endocrinological, biochemical and statistical. Results. Results of research testify to existence of direct dependence of frequency of obstetric and perinatal complications respectively from existence of the combined pathology with the obvious prevails at combination of diffuse dysplasia of mammary glands and an adenomyosis. Results of complex assessment functional condition of fetoplacental complex at patients with the combined pathology testify to existence of features of placental dysfunction which is absent at patients only with diffuse dysplasia of mammary glands, gains the compensated character at combination to uterus leiomyoma, and at a combination to an adenomyosis are the main reason of high frequency of perinatal pathology owing to placental dysfunction. Conclusion. The received results needs to be considered when developing algorithm of diagnostic and treatment-and-prophylactic actions at women with the combined pathology of uterus and mammary glands. Key words: pregnancy, labors, fetoplacental complex, diffuse dysplasia of mammary glands, uterus leiomyoma, adenomyosis.
Lifestyle modification as auxiliary pregravid preparation and prevention of obstetric complications in women with adenomyosis
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova NAMS of Ukraine, Kiev, Skripchenko N.Ya. , Pavlova O.M. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova NAMS of Ukraine, Kiev, Mazur T.M. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova NAMS of Ukraine, Kiev
Published: March 2022

The objective: to evaluate the effectiveness of the proposed method of lifestyle correction as an auxiliary pregravid preparation and prevention of obstetric complications in women with adenomyosis. Patients and methods. 65 patients of reproductive age (29–32 years) with adenomyosis in 1–2 stage. Control group – 38 healthy women. Differences between the groups: pregravid preparation (group 1 received dietary recommendations and metered physical exercises, group 2 – combined oral contraceptives) and pregnancy (group І received progesterone therapy and diet therapy, group ІІ received exclusively progesterne therapy). Levels of progesterone, placental lactogen, tumor necrosis factor, interleukin-6, percentage of pregnancy, early miscarriage risks and reproductive loss were studied. Results. In 87% of women with adenomyosis there were manifestations of inflammation of different localization in pelvis, infertility – in 94% of women. The level of IL-6 in women with adenomyosis before treatment was increased by almost 2.6 times. The increase in tumor necrosis factor- is associated with dysfunction of the inner organs, as possible development factor of septic complications. The reduction of progesterone in patients with adenomyosis confirms the pathogenetic mechanism of the disease. In group I, 80% (28) had pregnancy, 42.8% (12) had risk of miscarriage, 14.3% (4) cases of reproductive loss. Pregnancy in group II was detected in 80% (24) cases, of which 50% (12) had a risk of miscarriage and 6 (25%) reproductive losses. Conclusions. Pregravidal preparation, which includes physical activity and dietary nutrition, contributed to improve reproductive function, normalized of the cytokine and hormonal profile in the progression of pregnancy, and contributed to the reduction in obstetric and perinatal losses in women with adenomyosis. Key words: adenomyosis, pregravidder training, lifestyle correction, pregnancy, obstetric complications.
Modern view on Great obstetrical syndromes (Foreign literature review)
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kiev, Romanenko T.H. , Mitsoda R.M. ,   FPE SHEE Uzhgorod national University, Bobik Y.Y. ,   FPE SHEE Uzhgorod national University, Lemish N.Y. ,   FPE SHEE Uzhgorod national University
Published: March 2022

The literature review summarizes the data about etiology, pathogenesis and possible methods of prophylaxis of great obstetrical syndromes. It is proven that these syndromes are caused by defective deep placentation due to obstruction, absent or partial transformation of spiral arteries of deciduo-myometrial interface, that is caused by hormonal imbalance. The perspective method of prophylaxis of great obstetrical syndromes is intake of medications, that might have a modulating effect of the factors mentioned above. Key words: great obstetrical syndromes, defective deep placentation, deciduo-myometrial interface, spital arteries, oxidative stress, decidual immune cells, preimplantational factor, progesterone-induced blocking factor, progesterone, dydrogesterone.
Screen Time: Society Costs vs Revenues of Transnational Corporations
Authors:   Volgograd State Agrarian University, Skokov Roman , Dugina Tatiana ,   Volgograd State Agrarian University
Published: March 2022

The article presents the periodization of the theory of behavioral design and the theory of time. The direction of the modern stage of development of behavioral design is digital technologies of persuasion, the tools of which are used to influence the behavior of users of social networks, video hosting and other digital goods. Social media accounts for half of the screen time. The business model of multinational technology corporations in the use of screen time is to advertise, collect and sell user data, which can also be accompanied by the formation of a shadow market. Digital persuasion technologies are addictive and provide an increase in the time users spend on social networks. When assessing the use of unproductive screen time, the lost value of time must be taken into account. Social losses of unproductive use of digital goods are significant and tend to grow in a pandemic, turning into revenue for companies. In the absence of public and state regulation of the use of digital technologies of persuasion in digital goods and their uncontrolled use, children and youth are the most vulnerable category. Within the framework of the evolutionary development of synergetics, the source of which is disequilibrium, instability, irreversibility and nonlinearity of time, it is necessary to pay attention to the mechanism of self-organization of users.
Identification of Dependence Between Financial Instruments for Structuring a Venture Round of Financing and the Portfolio Company’s Investment Stage of Development
Authors:   National Research University Higher School of Economics, Makushina Elena
Published: March 2022

The purpose of this article is to identify the financial instruments that a venture capital fund uses when structuring а round of financing and the investment stages of development of a portfolio company. Based on a systematic literature review we investigated the portfolio companies’ investment stages, at which venture capital investments are made: seed stage, start-up stage, early stage, expansion stage. As a result of this study the definition of “venture investments” has been clarified. This article examines the financial instruments that venture capital funds use to structure a deal with portfolio companies’ founders on the venture stages of development. It has been established that the choice of financial instruments is the result of the negotiation process between the venture capital fund and new venture founders and depends on the risk of failure, which is determined by the investment stage of the portfolio company. Moreover, shortcomings of the national legislative regulation system were highlighted, and positive trends were noted in the national rule-making process – the adoption of a federal law that establishes the procedure for using a convertible loan. The possible ways of structuring the transaction between the founders and domestic venture capital funds formed under investment partnership agreements were identified. The results obtained can be used to build a venture infrastructure with operating mechanisms that are understandable for foreign investors.
Modelling Credit Process
Authors:   Orenburg State University, Revtova Elena
Published: March 2022

The article examines the economic phenomenon of credit. The target is to develop a model for element interaction method in the credit process. Hypothesis: it is assumed that scientific research based on a systematic approach is able to reveal the interacting elements in the credit process detail this process and describe the mechanism of its management. The following universal scientific methods have been used: the “black box” method, the element interaction method and the method of interaction of elements in the system with feedback. A three main components have been obtained. The first one is process model of a “black box” loan. The model contains the necessary resource for transformation in the credit process, the block-converter and the pattern of functional dependence the output has acquired on its input. The second one is a simple universal model of the relationship between the elements of the credit process in the system. The model shows the interacting elements of the credit, the specificity of the interaction of the elements, the result of the interaction of the elements of the credit and the effect on the credit and its external environment. The third one is a universal model of the relationship between the elements of the credit process in a system with feedback. The mechanism of regulating processes in the loan has been observed, identified and shown through feedback. The study has provided evidence that to start credit process in target groups they should be in disposition: one lacks all monetary and non-monetary resources whereas the other has an overflow of them; the interacting elements in the loan are efficiency, capacity to pay and pay back; feedback facility can regulate the processes moving in the credit system. Study results having been discovered through research expand the scientific understanding of the processes taking place inside loan. They can be used for an in-depth study of the loan by detailing the components of the model, and for modelling different scenarios of the credit process and its management modes.
The Fourth Industrial Revolution and a Modern Model of Functioning of Economic Systems (Reflections on the Book: Bloommart, T. The Fourth Industrial Revolution and Business: How to Compete and Develop in the Era of Singularity [Text] : Transl. from English / T. Bloommart, S. van den Brook with the participation of E. Koltof. – Moscow : Alpina Pablisher, 2019. – 204 p.)
Authors:   Volgograd State University, Averina Irina
Published: March 2022

The article examines the main points of the book by T. Bloommart and S. Brook “The Fourth Industrial Revolution and Business: How to Compete and Develop in the Era of the Singularity”. The author reflects on the phenomena “technological singularity”, “singular environment”, “ecosystem”, “technological platform”, “exponential and divergent development of economic systems”, “synergistic innovation culture” and their defining influence on the Industrial Revolution 4.0. The issues of changes in the labor market (the emergence of new professions and the dying off of a number of old ones), in business management models (the need for bimodal business management), radical transformations of competitive advantages (avoiding mass production and focusing on a specific consumer, returning capital from countries with cheap labor), the impact of existing or generated institutional barriers on economic systems of various levels within the studied phenomenon. The tasks of economic entities have been determined for the mega- (economic growth, dissonance between environmental friendliness and innovation, the impact of the global financial system on the rate of technological change); macro- ; and meso- (creation and development of new technological platforms and ecosystems, personnel training); microlevel (implementation of a bimodal model management, identification and timely preparation of the organization for adaptation in the presence of disruptive technologies in the industry, the need for the exponential development of the organization), which confront them with new technological realities that require timely resolution in the future.