bluuebunny/crossref_metadata_2025 huggingface dataset:
Why does the river erosion situation become more complicated in the Mekong delta?
Authors:   Former Director of Southern Institute for Water Resources Planning, Nguyen Ngoc Anh
Published: June 2018

Being a young river located in the delta that has been forming for a few thousand years now and developing during the several hundred years in the recent past under the pressure of socio-economic development, the impact of climate changes, rise in the sea level, and the Mekong upstream development, the riverbeds and coasts in the Mekong Delta have currently transformed the erosion from an acceptable "chronic" and "essential" situation to a complicated, unpredictable, and alarming one. This is the cause behind the serious damages to local people and the infrastructures along the river banks and coastlines. Understanding the basic causes, recognizing the continuous trends, or proposing the effective and feasible response solutions are the most important problems for the local people and the authorities, those of the Central Government and the those in the localities. Therefore, we must prepare for river banks' or coastlines' and valuable materials' or entities' protection, plan and stabilize the populated areas along the river banks and coasts, especially in the high-risk erosion areas. These are the major contents that would be presented as follow.
Synthesis and antimicrobial evaluation with DFT study for new thiazole derivatives
Authors: Abbas Sumayah Saadi , Kubba Ammar A.Razzak Mahmood
Published: June 2018

Two compounds,[2-amino-4-(4-nitro phenyl) 1,3-thiazole],(4) and [2-amino-4-(4-bromo phenyl) 1,3-thiazole],(5), were synthesized by refluxing thiourea (1) with each of  para-ntiro and para-bomophanacyl bromides(2) and (3) respectively, in absolute methanol. Then, by reaction of [5] with 3,5-dinitrobenzoyl chloride in dimethylformamide (DMF) yielded  (6) .On the other hand, reaction of (4) with chloroacetyl chloride in dry benzene afforded (7), which is  upon treatment with thiourea in absolute methanol, afforded (8) . The characterization of the titled compounds were done utilizing FTIR spectroscopy, 1HNMR, CHNS elemental analysis and by measurements of  their physical properties. The synthesized compounds had been screened for their, in vitro  preliminary antimicrobial activity against four Gram positive bacteria (Staph. aureus, Micrococcus luteus, Bacillus subtilis and Bacillus pumilus),  and four Gram negative bacteria (Pseud.aeroginosa, E.coli, Proteus mirabilis and Klebsiella pneumoniae)and three fungi species: (Saccharomyces cerevisiae, Candida Tropicalis and Candida albicans) using a minimum  inhibitory concentration (MIC) of 100 µg\ml of derivative  in dimethylsulfoxide, by  well diffusion method.

Compound (6) showed moderate antibacterial activity against some tested Gram positive bacteria (Bacillus pumilus and Bacillus Subtilis) and a moderate antifungal activity towards Candida albicans. Computational study was performed   to calculate some of the thermodynamic parameters of synthesized derivatives by using density functional theory (DFT).
Mechanical properties and fracture mechanism of glass fiber/epoxy composites
Authors: Li Jian , Su Haidi , Gao Xueshan , Ju Linfeng
Published: June 2018

Glass fiber/epoxy composites exhibit varied behaviors in the Z direction (the direction perpendicular to the layers) and × direction (the direction parallel to the layers). The mechanical properties of these materials, subject to quasi-static compressive and tensile loadings, are investigated using a tensile testing machine and by means of the pasting strain gauge method. The results of the tests show that the compressive strength in the Z direction is higher than that in the × direction, whereas tensile strength exhibits the opposite. A split Hopkinson pressure bar was used to investigate the dynamic behavior of the composite. The strain rate-reinforcement effect of the material can clearly be found. In the Z direction and × direction, compressive strength attains its maximum at a strain rate of 2030 s−1 and 2100 s−1 respectively. The maximum compressive strength in the Z direction is 90 MPa higher than that in the × direction. At the same strain rate, the elastic modulus in the Z direction is higher than that in the × direction, which means that stiffness in the Z direction is higher than that in the × direction. The focus then turns to failure modes and fracture mechanisms of the composite. A scanning electron microscope shows that a macroscopic brittle fracture is mainly caused by fiber breakage and matrix cracking. However, shear failure of the matrix and delamination and buckling of the glass fiber laminates also lead to macroscopic shear failure.
Effect of cell size on the energy absorption of closed-cell aluminum foam
Authors: Xu Jinglin , Liu Jianqing , Gu Wenbin , Wang Zhenxiong , Liu Xin , Cao Tao
Published: June 2018

Aluminum foam could be used as a defense against explosion and shock wave. Its energy absorption capability is an important indicator to evaluate its blast resisting ability. But since the impedance of aluminum foam is much lower than that of metal, it is hard to measure its exact stress-strain relation by means of the traditional Split Hopkinson pressure bar (SHPB) method. To evaluate the energy absorption characteristic of aluminum foams of varied cell sizes, an improved SHPB method is proposed. This improved method can enhance the accuracy of the stress-strain curve of aluminum foam and by using a longer striker, might increase the strain on the samples. Two aluminum foams of different cell sizes were selected. The experimental results show that the cell size of the aluminum foam and the strain rate have a significant effect on the compressive characteristics and energy absorption. Smaller cell aluminum foam is stronger than that with larger cells due to fewer flaws in the microstructure. Aluminum foam of a smaller cell size can absorb more energy than larger cell aluminum foam due to higher plateau stress. The energy absorption of smaller cell aluminum foam increases by 42 % at strain rate 3579 s−1 compared with quasi-static compression while larger cell foam increases 55 % at a strain rate of 1586 s−1.
UTILIZING A WEBSITE TO INCREASE EDUCATION QUALITY AWARENESS IN WEST KALIMANTAN RURAL VILLAGES
Authors: Ernawaty Ernawaty , Chandra Yakob Utama
Published: June 2018

Education already become a basic human right since they were born. But geographical condition differentiates the level of education quality they get. Especially in most development countries with low implementation of ICT (Information, Communication, and Technology). In this digital era, it is hard to achieve an effective and efficient learning environment in rural areas. Infrastructures and teaching tools in those areas are very humble. Few books can be read. With limited educational background, social-economy issues will always keep remain. Love Borneo is an organic community that want to make a change for children in rural villages in West Kalimantan. They build a facility called Rumah Baca that provide good quality books suitable for children. They collect donated books and some money to buy books and educational games for children. Since 2015, they already build 10 Rumah Baca. But there are still so many villages that need this kind of facility. To build awareness about education for children in rural villages, this article discusses the development of a dedicated website called www.loveborneo.org that provides up to date information about this community and their activities. People around the world can access this website and can officially support this community. www.loveborneo.org is only one example of ICT implementation to help rural citizens.
ANDROID APPLICATION FOR DETECTION OF SKIN CANCER USING EXPERT SYSTEM
Authors: Udjaja Yogi
Published: June 2018

Skin cancer is an abnormal growth of human skin that can damage skin cells. By knowing the symptoms of skin cancer as early as posssible, it is helpful in preventing the spread of cancer cells and treatment. There are many factors that cause skin cancer, but in general the cause is exposure to ultraviolet rays from the sun.  Therefore, an expert system application is required to detect skin cancer.  By using backward chining and probalility methode; which data is in form of someone’s risk factor and clinical sympthoms, then the application will provide temporary diagnosis.  This application is built in an android platfrom because in its development android is more used than other platforms. The accuracy obtained from this application is 96.67%.
THE INFLUENCE OF SERVICE QUALITY, PERCEIVED VALUE AND CORPORATE IMAGE TOWARD INPATIENT SATISFACTION ON PRIVATE HOSPITAL
Authors: Novela Selly , Ronaldy Johanes
Published: June 2018

The purpose of this research was to determine the influence of service quality, perceived value, and corporate image of the hospital toward inpatient satisfaction of private hospitals in Jabodetabek.  This study is categorized as a survey research, where researchers distributed questionnaires to 155 respondents who had been inpatients in private hospitals in Jabodetabek area. The method that used in this research is quantitative method and descriptive analysis. The method used in this research is simple and multiple linear regressions using SPSS v20. The results of this research showed that service quality, perceived value, and corporate image of Private Hospitals in Jabodetabek have significantly affect patient satisfaction on private hospitals in Jabodetabek.
Reflexões sobre a mudança de paradigmas no ensino tecnológico
Authors: Nascimento Erlande D Ávila D Ávila , Souza Ana Claúdia Ribeiro de , De Oliveira Silmar Antonio Buchner
Published: June 2018

Este artigo discute a relação entre as mudanças de paradigmas no ensino tecnológico. Apresentamos a pesquisa bibliográfica, com uma breve revisão e análise da obra de Thomas Khun ‘A estrutura das revoluções cientificas’ à luz de ideias como: as revoluções como mudanças de concepção de mundo, trazendo um debate importante sobre a prática científica. Discutimos sobre Tecnologia na educação: São mudanças necessárias? E o Ensino tecnológico, uma revolução científica possível? A discussão aponta para compreensão de que a mudança de paradigmas na educação, leva-nos a ver o mundo de maneira diferente, e na medida em que compreendemos o que vemos e fazemos, poderemos dizer que, após uma revolução científica, reagiremos diferente sobre percepção de mundo e o conceito de ensino tecnológico. A discussão é ampla e necessária ser debatida, tendo em vista a falta e insuficiência de ações inovadoras que aumentem o debate sobre mudanças de paradigmas na educação e as consequências para o ensino tecnológico.
Processo editorial em revistas científicas: o gerenciamento de produtos na Revista Educitec
Authors: De Andrade Tatiane Sabino da Silva , Gonzaga Amarildo Menezes
Published: June 2018

Este estudo tem o objetivo de compreender como ocorre o processo editorial e o gerenciamento de produtos numa revista científica, tendo como referencial norteador a Revista de Estudos e Pesquisas sobre Ensino Tecnológico (EDUCITEC). Tal busca culminou na imersão da pesquisadora no âmbito da Educitec, integrando a equipe editorial, de modo a conhecer o cotidiano desta. A investigação pautou-se nos trabalhos submetidos, aceitos e publicados nas três edições da Revista Educitec. Desvelamos que a submissão de trabalhos categorizados em artigos, relatos de experiências e resenhas, faz parte de uma condição processual, no que tange a avaliação, revisão, edição e publicação dos trabalhos e que envolve experiências relacionadas ao ensino tecnológico, onde a comunicação científica é aprimorada.
Uso de recursos tecnológicos nos Telecentros: construindo práticas de formação continuada
Authors: Santana Ieda Lucia , Coelho Iandra Maria
Published: June 2018

Este artigo é resultado parcial de uma pesquisa que está sendo desenvolvida no Mestrado Profissional em Ensino Tecnológico, do Instituto Federal de Educação, Ciência e Tecnologia do Amazonas. Nessa proposta, apresentamos uma investigação, de natureza exploratória, que tem como objetivo identificar os recursos tecnológicos utilizados nos Telecentros de Manaus e as dificuldades encontradas, visando contribuir para a mediação de práticas formativas dos servidores responsáveis por coordenar estes espaços.  Numa perspectiva metodológica, contempla procedimentos de análise documental e a realização de um questionário que contou com a participação de 69 coordenadores. Os resultados identificam entre os recursos mais utilizados, o software Movie Maker, as pesquisas na internet e ferramentas do BrOffice, para a realização de projetos, oficinas e atividades socioeducativas. Entre as dificuldades destacam-se problemas com a infraestrutura e a resistência dos docentes quanto ao uso das ferramentas tecnológicas para o acesso à informação e conhecimentos complementares às atividades escolares.
Pesquisa em educação: desafios na formação de professores no IFMT Campus Confresa
Authors: Tasinaffo Alves Ana Claudia , Palma Rute Cristina Domingos da , Leão Marcelo Franco , Lopes Thiago Beirigo
Published: June 2018

O presente trabalho apresenta os resultados de uma pesquisa que objetivou quantificar quais as temáticas foram investigadas pelos professores nos projetos de pesquisa desenvolvidos no Instituto Federal de Mato Grosso (IFMT) Campus Confresa, a fim de discutir a importância da Pesquisa em Educação nos cursos de formação inicial de professores. Para tanto, buscou-se fazer um levantamento dos projetos aprovados pelos professores desse Campus em editais da própria instituição. Em 2010, o Campus foi inaugurado e iniciou a oferta de dois cursos de licenciaturas e a partir de 2015 passou a ser quatro cursos para formação de professores. No entanto, um curso estava em processo de extinção e não havia oferta de novas matrículas. Após o levantamento dos projetos, no período de 2010 a 2015, verificou-se que foram desenvolvidos vários projetos de pesquisas, entretanto, apenas uma pequena parcela voltada à temas relacionados a área de Ensino ou de Educação. Diante dos resultados, faz-se urgente a discussão e formação de grupos de pesquisa voltadas para a formação de professores pesquisadores para o exercício da docência.
Interdependence of body mass index with handgrip strength and endurance among apparently healthy teenagers
Authors: Hammed Adebisi I. , Obaseki Chigozie O.
Published: May 2018

This study investigated the relationship of body mass index (BMI) with handgrip strength and endurance among apparently healthy Nigerian Teenagers. A total of 200 secondary school students participated in this study. Body height and body weight were measured with a wall–mounted stadiometer in meters (m) and bathroom weighing scale in kilogram (kg) respectively. Body mass index (BMI) was then calculated using the formula weight (kg)/height (m2). An electronic handgrip dynamometer was used to measure handgrip strength (HGS) in kg and handgrip endurance (HGE) in seconds (s). The relationship of BMI with HGS and HGE was analyzed using Pearson’s product moment coefficient of correlation. Then, differences in BMI, HGS and HGE across gender categories were analyzed using the independent sample t-test. The outcome of this study showed that BMI correlated proportionately and significantly (p < 0.05) with HGS and HGE. Also, a significant difference (p < 0.05) exists in HGS and HGE across gender characteristics.  This study therefore concluded that BMI is a determinant of HGS and HGE among apparently healthy Nigerian Teenagers and thus, could be considered as a marker of nutritional and health status, as well as physical fitness of these individuals. Also, a gender difference does influence HGS and HGE among apparently healthy Nigerian Teenagers.
تطبيق طريقة القراءة السريعة فى تعليم مهارة القراءة صف الحادى عشر للبنات بمعهد دار الأبرار بونى
Authors: Jamal Mardhiana
Published: June 2018

هذ البحث يبحث عن تطبيق طريقة القراءة السريعة ((Quantum Reading فى تعليم مهارة القراءة صف الحادى عشر للبنات بمعهد دار الأبرار بونى. وتستخدم الباحثة منهجا وصفيا على المدخل الكيفي، بطريقتين لأدوات البحث هما: الملاحظة والمقابلة. وأما المشكلة التى تواجهها الطالبات فى تعليم مهارة القراءة هي عدم قدرة الطالبات وكفائتهن في إجابة الأسئلة وصعوبة في فهم مادة قراءة اللغة العربية. ذلك لأنهن يعتمدن نظام حفظ المادة بعدم فهم المادة. فتقدم الباحثة في هذا البحث لإجابة سؤال واحد هي:كيف تطبيق طريقة القراءة السريعة فى تعليم مهارة القراءة صف الحادى عشر للبنات بمعهد دار الأبرار بونى ؟.وأما النتيجة هي: أن تطبيق القراءة السريعة فى تعليم مهارة القراءة جيد جدا لأن الطالبات يستطعن على فهم نص القراءة بسرعة ويزداد حبهن في القراءة، باتباع الشروط المذكورة في خطوات  تطبيق القراءة السريعة.
Perancangan Media Pembelajaran Listrik Statis dan Dinamis Berbasis Android
Authors: Zaus Mahesi Agni , Wulansari Rizky Ema , Islami Syaiful , Pernanda Doni
Published: June 2018

This study discusses about design of static electricity and dynamic electricity learning media based on Android. designed learning media containing static and dynamic electrical materials that are abstract and not visible to see. The material is described in real and easily understood by learners. The method used in the design of learning media is System Development Life Cycle Waterfall model. And the design model of learning media using Unified Modeling Language with Use case diagram, flowchart and then developed using Adobe Flash CS6 tool. The results of this study indicate that the learning tool of static and dynamic electricity based on android easy to use for learners and teachers in the learning process.Keyword : Learning Tools, Android, Static Electricity, Dynamic Electricity
Teknik Marker Based Tracking Augmented Reality untuk Visualisasi Anatomi Organ Tubuh Manusia Berbasis Android
Authors: Perwitasari Ika Devi
Published: June 2018

This study aims to learn the technique of Marker Based Tracking Augmented Reality which is implemented for Visualization of Anatomy of Human Body Organs. Augmented Reality Visualization Applications Anatomy of the Human Body Organ is built on the Android mobile platform device. In the analysis of the application interface design using the approach of User Center Design. Testing the application using Usability Test. Based on the results of implementation and testing, Marker Based AR technique successfully applied in making Visualization Applications Anatomy Human Body Organs on Android Platform. Applications use markers to display digital content 2D images of the brain, eyes, heart, and lungs. The results of the Usability Test show users can see organ anatomy information very clearly and users are very interested in using the applications created because it provides a different experience in learning.Keywords : Augmented Reality, Marker Based Tracking, Human Organs, User Center Design
Penerapan Metode Pembelajaran Matematika Berbasis ICT pada SDN 14 Kecamatan Lubuk Begalung Padang
Authors: Putri Ranti Eka
Published: June 2018

Learning media is a container, facilities or facilities that can provide convenience to educators to convey messages or information to be received well and interesting by students. Selection of appropriate learning media will give effect and influence in realizing the achievement of learning objectives. With the availability of instructional media, educators can create classroom situations, determine what teaching methods will be used in different situations and create a healthy emotional climate among learners. In the process of teaching and learning at SDN 14 Padang, what happens in learning often happen the teaching process runs ineffectively. A lot of time, and energy wasted while the goal of learning cant be achieved even happen noises or voice that is not important in communication between teachers and students. For that purpose, it is designed the instructional media which is devoted to the field of mathematics study in discussing material about multiplication, division, addition and subtraction by using Adobe Flash CS3.

Keywords : Learning Media, ICT, Adobe Flash CS3
Sistem Pendukung Keputusan Pemilihan Penerimaan Beasiswa Berprestasi Menggunakan Metode Elimination Et Choix Traduisant La Realite
Authors: Tasril Virdyra
Published: June 2018

Selection of grantee candidates in SMA Negeri 20 Bagan Deli is still done manually. Prospective scholarship recipients are selected based on the criteria determined by SMA Negeri 20 Bagan Deli. One of the best methods used for this problem is the ELECTRE method and is also one of the most effective methods for making multiple decision choices with clear features that are not clear. This method uses conditions where inappropriate alternatives are eliminated to obtain the expected results. Therefore, this method is widely used for cases that have many options but few criteria are involved. This research is expected to provide convenience for the school in determining scholarships on their students.

Keywords: Decision Support System, Electre, Scholarship
Case Based Reasoning untuk Diagnosis Penyakit Jantung Menggunakan Metode Minkowski Distance
Authors: Wahyudi Eka , Pradasari Novi Indah
Published: June 2018

Case Based Reasoning is a computer system that used for reasoning old knowledge to solve new problems. It works by looking at the closest old case to the new case. This research attempts to establish a system of CBR  for diagnosing heart disease. The diagnosis process  is done by inserting new cases containing symptoms into the system, then  the similarity value calculation between cases  uses the minkowski distance similarity. Case taken is the case with the highest similarity value. If a case does not succeed in the diagnosis or threshold less than 0.80, the case will be revised by experts. Revised successful cases are stored to add the system knowledge. Method with the best diagnostic result accuracy will be used in building the CBR system for heart disease diagnosis. The test results using medical records data validated by expert indicate that the system is able to recognize diseases heart using minskowski distance similarity correctly of 100 percent. Using minkowski get accuracy of 100 percent.

 Keywords : Case Based Reasoning, Minkowski Distance Similarity.
Expo Milano 2015: effetti sulle performance delle strutture alberghiere
Authors: Mauri Aurelio G. , Sainaghi Ruggero
Published: May 2018

I grandi eventi possono determinare significativi effetti sulle performance delle destinazioni turistiche e delle imprese che in esse operano. Tuttavia, in letteratura si è posta maggiormente l'attenzione sui fattori non economici generati da queste "special occasion". Il presente articolo vuole contribuire a colmare questo gap, esplorando i benefici economici generati dall'esposizione mondiale "Milan World Expo 2015" sul comparto alberghiero di Milano.L'articolo, partendo dagli studi pregressi che hanno analizzato le forme di stagionalità in questa destinazione, configura quattro periodi, identificati considerando soprattutto i segmenti attratti dalla Città (business, fieristico e leisure). La base dati utilizzata (STR) consente di disporre di informazioni giornaliere relative a occupazione, tariffa media (ADR) e RevPAR e permette di sviluppare un approccio longitudinale (periodo 2004-2015).Le evidenze emerse suggeriscono il rilevante impatto generato da Expo sia sulle stagionalità, sia sulle performance operative. Con riferimento a queste ultime, il RevPAR è cresciuto, in termini reali, del 68% considerando il dato di partenza (2004) e del 50% rispetto al 2014. Non meno importante è la crescita della saturazione della capacità ricettiva (+25%) e del prezzo medio reale (+34%).
Stima ed interpretazione nella determinazione del prezzo edonico degli immobili: il caso di Genova
Authors: Bruzzo Alessia
Published: May 2018

Questo lavoro contiene un'analisi empirica volta a interpretare la determinazione dei prezzi di mercato delle abitazioni secondo quanto sostenuto dalla teoria del prezzo edonico applicata ad un'ampia zona di tipo marittimo, il comune di Genova.L'analisi empirica si basa su un campione specificatamente creato raccogliendo i dati relativi l'offerta immobiliare catturata in un determinato periodo del 2015. L'obiettivo proposto è puramente empirico e punta ad interpretare il ruolo esercitato dalle diverse caratteristiche intrinseche di un'abitazione nella determinazione del suo prezzo. Questo tipo di analisi viene fatta su un campione eterogeneo, caratterizzato tanto da zone ad alta valutazione, di tipo per lo più turistico o prestigioso, quanto da zone suburbane industriali di basso valore e zone urbane collegate all'attività portuale. Comparando il modello semplice con la teoria del prezzo edonico, otteniamo quattro differenti regressioni, due per ogni modello: un modello robustoOLS e un modello clusterizzato con variabili strumentali. Come nel lavoro di Caglayan (2013), il modello edonico stimato restituisce migliori e più precisi risultati rispetto al modello di tipo semplice. E all'interno del modello di tipo edonico le variabili di tipo strumentali performano meglio rispetto al modello robusto OLS.
Different health related days in a calendar year observing worldwide
Authors: Laskar MS
Published: June 2018

There are many world days observed throughout the year related to specific health issues or conditions. Thus observing the different health related days maintaining a high-profile focus on universal health coverage via a series of events with global and local conversations about ways to achieve ‘Health for All’ is emphasized. The idea of observing such health related days for awareness is to spread knowledge on health issues and empower people in the decision making on health diagnosis and medical treatments. The observations seem to be reinforcing that it is a good step, and it might be even sufficient to address the health issue. Specific health related day may just be one day, but it is a day that needs to remind the importance of health as something that needs to be a part of everyday life. This article gives a brief description of different health related days in a calendar year observing worldwide.Mediscope Vol. 5, No. 1: Jan 2018, Page 1-4
Risk factors and causes associated with maternal mortality in a rural tertiary level hospital in Bangladesh
Authors: Tazri SA , Ahmed M , Shumsun MN , Raza AM
Published: June 2018

The aim of the study was to find out the risk factors and causes of maternal mortality in rural hospitals of Bangladesh. The retrospective study was conducted at the Department of Obstetrics and Gynaecology, Jahurul Islam Medical College Hospital with duration of 3 years from May 2009 to April 2012. Total number of maternal deaths was 21 yielding the rate of maternal death as 7.0 per 1000 live births during the study period. The risk factors were age ranging from 21 to 25 years, primigravida, low socioeconomic condition, and less antenatal checkup. Eclampsia was the leading cause of death followed by obstetric hemorrhage, unsafe abortion, obstructed labour.Mediscope Vol. 5, No. 1: Jan 2018, Page 28-32
An Integrated Cyber Security Risk Management Approach for a Cyber-Physical System
Authors: Kure Halima Ibrahim , Islam Shareeful , Razzaque Mohammad Abdur
Published: May 2018

A cyber-physical system (CPS) is a combination of physical system components with cyber capabilities that have a very tight interconnectivity. CPS is a widely used technology in many applications, including electric power systems, communications, and transportation, and healthcare systems. These are critical national infrastructures. Cybersecurity attack is one of the major threats for a CPS because of many reasons, including complexity and interdependencies among various system components, integration of communication, computing, and control technology. Cybersecurity attacks may lead to various risks affecting the critical infrastructure business continuity, including degradation of production and performance, unavailability of critical services, and violation of the regulation. Managing cybersecurity risks is very important to protect CPS. However, risk management is challenging due to the inherent complex and evolving nature of the CPS system and recent attack trends. This paper presents an integrated cybersecurity risk management framework to assess and manage the risks in a proactive manner. Our work follows the existing risk management practice and standard and considers risks from the stakeholder model, cyber, and physical system components along with their dependencies. The approach enables identification of critical CPS assets and assesses the impact of vulnerabilities that affect the assets. It also presents a cybersecurity attack scenario that incorporates a cascading effect of threats and vulnerabilities to the assets. The attack model helps to determine the appropriate risk levels and their corresponding mitigation process. We present a power grid system to illustrate the applicability of our work. The result suggests that risk in a CPS of a critical infrastructure depends mainly on cyber-physical attack scenarios and the context of the organization. The involved risks in the studied context are both from the technical and nontechnical aspects of the CPS.
Headphone-To-Ear Transfer Function Estimation Using Measured Acoustic Parameters
Authors: Liu Jinlin , Deng Huiqun , Ji Peifeng , Yang Jun
Published: June 2018

This paper proposes to use an optimal five-microphone array method to measure the headphone acoustic reflectance and equivalent sound sources needed in the estimation of headphone-to-ear transfer functions (HpTFs). The performance of this method is theoretically analyzed and experimentally investigated. With the measured acoustic parameters HpTFs for different headphones and ear canal area functions are estimated based on a computational acoustic model. The estimation results show that HpTFs vary considerably with headphones and ear canals, which suggests that individualized compensations for HpTFs are necessary for headphones to reproduce desired sounds for different listeners.
Correction: Recent Advances in Atmospheric Chemistry of Mercury
Authors: Si Lin , Ariya Parisa ,   Atmosphere Editorial Office
Published: May 2018

The published paper [1] has been updated to remove instances of copied text from other publications [2–6].[...]
Assessment of Air Thermal Conditions in the Lowland Part of South-Western Poland for Agriculture Development Purposes
Authors: Kalbarczyk Robert , Kalbarczyk Eliza , Ziemiańska Monika , Raszka Beata
Published: June 2018

The recognition of changes in the course of agricultural thermal periods is vital when it comes to determining appropriate measures for adapting agriculture to climate change. The present study examined changes in air temperature between 1951 and 2014 in the area of south-western Poland. A statistically significant, positive linear trend was confirmed for the annual average temperature, seasonal averages, and monthly averages in the periods spanning February–May and July–August. From the beginning of the 21st century, the period of winter dormancy of plants started increasingly later; farming and plant vegetation periods started increasingly earlier, and the period of active plant growth was prolonged. Among the considered agricultural periods, the growing season was the most prolonged. The duration of the farming period was also significantly longer, but the winter dormancy period was shortened. The negative linear trend of days when the temperature stood at <0 °C was statistically confirmed for temperature in the entire region and most of the stations. In terms of predicting the consequences of the changes that were observed today over the next decades, this is not an easy task. However, the nature of these changes suggests that further cultivation of winter crops may require far-reaching adaptation measures.
Coupled Simulations of Indoor-Outdoor Flow Fields for Cross-Ventilation of a Building in a Simplified Urban Array
Authors: Murakami Yuki , Ikegaya Naoki , Hagishima Aya , Tanimoto Jun
Published: June 2018

Computational fluid dynamics simulations with a Reynolds-averaged Navier-Stokes model were performed for flow fields over a building array and inside a building in the array with different building opening positions. Ten combinations of opening locations were selected to investigate the effect of the locations on indoor cross-ventilation rates. The results of these simulations show that the exterior distributions of mean wind speed and turbulence kinetic energy hardly differ even though building openings exist. Although similar patterns of outdoor flow fields were observed, the opening positions produced two different types of ventilations: one-way and two-way. In one-way ventilation, the wind flows through the opening are unidirectional: diagonally downward at the windward wall. In two-way ventilation, both inflow and outflow simultaneously occur through the same opening. Determination of ventilation rates showed that the ventilation types can explain what type of ventilation rate may be significant for each opening location.
Opacity Effects on Pulsations of Main-Sequence A-Type Stars
Authors: Guzik Joyce , Fontes Christopher , Fryer Chris
Published: June 2018

Opacity enhancements for stellar interior conditions have been explored to explain observed pulsation frequencies and to extend the pulsation instability region for B-type main-sequence variable stars. For these stars, the pulsations are driven in the region of the opacity bump of Fe-group elements at ∼200,000 K in the stellar envelope. Here we explore effects of opacity enhancements for the somewhat cooler main-sequence A-type stars, in which p-mode pulsations are driven instead in the second helium ionization region at ∼50,000 K. We compare models using the new LANL OPLIB vs. LLNL OPAL opacities for the AGSS09 solar mixture. For models of two solar masses and effective temperature 7600 K, opacity enhancements have only a mild effect on pulsations, shifting mode frequencies and/or slightly changing kinetic-energy growth rates. Increased opacity near the bump at 200,000 K can induce convection that may alter composition gradients created by diffusive settling and radiative levitation. Opacity increases around the hydrogen and 1st He ionization region (∼13,000 K) can cause additional higher-frequency p modes to be excited, raising the possibility that improved treatment of these layers may result in prediction of new modes that could be tested by observations. New or wider convective zones and higher convective velocities produced by opacity increases could also affect angular momentum transport during evolution. More work needs to be done to quantify the effects of opacity on the boundaries of the pulsation instability regions for A-type stars.
Redesigning TOR Kinase to Explore the Structural Basis for TORC1 and TORC2 Assembly
Authors: Hill Andrew , Niles Brad , Cuyegkeng Andrew , Powers Ted
Published: June 2018

TOR is a serine/threonine protein kinase that assembles into distinct TOR Complexes 1 and 2 (TORC1 or TORC2) to regulate cell growth. In mammalian cells, a single mTOR incorporates stably into mTORC1 and mTORC2. By contrast, in Saccharomyces cerevisiae, two highly similar Tor1 and Tor2 proteins exist, where Tor1 assembles exclusively into TORC1 and Tor2 assembles preferentially into TORC2. To gain insight into TOR complex assembly, we used this bifurcation in yeast to identify structural elements within Tor1 and Tor2 that govern their complex specificity. We have identified a concise region of ~500 amino acids within the N-terminus of Tor2, which we term the Major Assembly Specificity (MAS) domain, that is sufficient to confer significant TORC2 activity when placed into an otherwise Tor1 protein. Consistently, introduction of the corresponding MAS domain from Tor1 into an otherwise Tor2 is sufficient to confer stable association with TORC1-specific components. Remarkably, much like mTOR, this latter chimera also retains stable interactions with TORC2 components, indicating that determinants throughout Tor1/Tor2 contribute to complex specificity. Our findings are in excellent agreement with recent ultrastructural studies of TORC1 and TORC2, where the MAS domain is involved in quaternary interactions important for complex formation and/or stability.
Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses
Authors: Nguyen Teresa , Avci Naze G. , Shin Dong Ho , Martinez-Velez Naiara , Jiang Hong
Published: May 2018

With the progress of immunotherapy in cancer, oncolytic viruses (OVs) have attracted more and more attention during the past decade. Due to their cancer-selective and immunogenic properties, OVs are considered ideal candidates to be combined with immunotherapy to increase both specificity and efficacy in cancer treatment. OVs preferentially replicate in and lyse cancer cells, resulting in in situ autovaccination leading to adaptive anti-virus and anti-tumor immunity. The main challenge in OV approaches is how to redirect the host immunity from anti-virus to anti-tumor and optimize the clinical outcome of cancer patients. Here, we summarize the conceptual updates on oncolytic virotherapy and immunotherapy in cancer, and the development of strategies to enhance the virus-mediated anti-tumor immune response, including: (1) arm OVs with cytokines to modulate innate and adaptive immunity; (2) combining OVs with immune checkpoint inhibitors to release T cell inhibition; (3) combining OVs with immune co-stimulators to enhance T cell activation. Future studies need to be enforced on developing strategies to augment the systemic effect on metastasized tumors.
Factors Influencing the Clinical Presentation of Breakthrough Pain in Cancer Patients
Authors: Mercadante Sebastiano , Marchetti Paolo , Cuomo Arturo , Caraceni Augusto , Mediati Rocco , Vellucci Renato , Mammucari Massimo , Natoli Silvia , Lazzari Marzia , Dauri Mario , Adile Claudio , Airoldi Mario , Azzarello Giuseppe , Bandera Mauro , Blasi Livio , Cartenì Giacomo , Chiurazzi Bruno , Costanzo Benedetta , Degiovanni Daniela , Fusco Flavio , Guardamagna Vittorio , Iaffaioli Vincenzo , Liguori Simeone , Palermo Loredana , Mameli Sergio , Masedu Francesco , Mattioli Rodolfo , Mazzei Teresita , Melotti Rita , Menardo Valentino , Miotti Danilo , Moroso Stefano , Pascoletti Gaetano , De Santis Stefano , Orsetti Remo , Papa Alfonso , Ricci Sergio , Scelzi Elvira , Sofia Michele , Tonini Giuseppe , Valle Alessandro , Aielli Federica ,   On behalf of the IOPS-MS Study Group
Published: June 2018

Background: The aim of this study was to identify potential variables influencing the clinical presentation of breakthrough cancer pain (BTP). Methods: Cancer patients with a diagnosis of BTP were enrolled. Demographic and clinical characteristics, as well as background pain and BTP characteristics were collected. Multivariate analyses were conducted to assess the correlation between BTP characteristics and the variables examined. Results: Data of 4016 patients were analysed. Average daily number of BTP episodes was 2.4, mean intensity was 7.5, and a mean duration was 43.3 min. A short onset BTP was observed in 68.9% of patients. In 30.5% of patients BTP was predictable. There were 86.0% of participants who reported a marked interference of BTP with their daily activities. Furthermore, 86.8% of patients were receiving opioids for the management of BTP. The average time to meaningful pain relief was 16.5 min and 70.9% of patients were satisfied with their BTP medications. Age, head and neck cancer, Karnofsky, background pain intensity, predictable and fast onset BTP were independently associated with the number of BTP episodes. BTP pain intensity was independently associated with background pain intensity, fast onset BTP, and Karnofsky. Neuropathic pain mechanism was independently associated with unpredictable BTP. Variables independently associated with a longer duration of BTP were age, place of visit, cancer diagnosis, disease-oriented therapy, background pain intensity and mechanism, and unpredictable BTP. Age, Karnofsky, background pain intensity, fast onset, and long duration of BTP were independently associated with interference with daily activity. Conclusions: BTP has a variable presentation depending on interdependent relationships among its different characteristics.
Frequency of EBV LMP-1 Promoter and Coding Variations in Burkitt Lymphoma Samples in Africa and South America and Peripheral Blood in Uganda
Authors: Liao Hsiao-Mei , Liu Hebing , Lei Heiyan , Li Bingjie , Chin Pei-Ju , Tsai Shien , Bhatia Kishor , Gutierrez Marina , Epelman Sidnei , Biggar Robert J. , Nkrumah Francis , Neequaye Janet , Ogwang Martin D. , Reynolds Steven J. , Lo Shyh-Ching , Mbulaiteye Sam M.
Published: June 2018

Epstein-Barr virus (EBV) is linked to several cancers, including endemic Burkitt lymphoma (eBL), but causal variants are unknown. We recently reported novel sequence variants in the LMP-1 gene and promoter in EBV genomes sequenced from 13 of 14 BL biopsies. Alignments of the novel sequence variants for 114 published EBV genomes, including 27 from BL cases, revealed four LMP-1 variant patterns, designated A to D. Pattern A variant was found in 48% of BL EBV genomes. Here, we used PCR-Sanger sequencing to evaluate 50 additional BL biopsies from Ghana, Brazil, and Argentina, and peripheral blood samples from 113 eBL cases and 115 controls in Uganda. Pattern A was found in 60.9% of 64 BL biopsies evaluated. Compared to PCR-negative subjects in Uganda, detection of Pattern A in peripheral blood was associated with eBL case status (odds ratio [OR] 31.7, 95% confidence interval: 6.8–149), controlling for relevant confounders. Variant Pattern A and Pattern D were associated with eBL case status, but with lower ORs (9.7 and 13.6, respectively). Our results support the hypothesis that EBV LMP-1 Pattern A may be associated with eBL, but it is not the sole associated variant. Further research is needed to replicate and elucidate our findings.
Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia
Authors: Lipof Jodi , Loh Kah , O’Dwyer Kristen , Liesveld Jane
Published: June 2018

Acute myeloid leukemia (AML) is a disease that affects adults aged 65 years and above, and survival in this population is poor. Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for these patients but is underutilized due to frequent comorbidities and perceived higher risk of treatment-related mortality and non-relapse mortality. Increasing data supports the utility of allo-HCT in fit older patients after intensive chemotherapy resulting in improvement of outcomes. With the development of reduced intensity and non-myeloablative conditioning regimens that are associated with lower rates of treatment-related toxicity and mortality, this has allowed more older patients with AML to receive allo-HCT. In this review, we provide some guidance on appropriate selection of older patients as transplant candidates, benefits and risks associated with allo-HCT, conditioning regimen choice, and stem cell transplant sources as they relate to the conduct of stem cell transplantation in older patients.
The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer
Authors: Pepe Felice , Visone Rosa , Veronese Angelo
Published: June 2018

The hsa-mir-483 gene, located within the IGF2 locus, transcribes for two mature microRNAs, miR-483-5p and miR-483-3p. This gene, whose regulation is mediated by the the CTNNB1/USF1 complex, shows an independent expression from its host gene IGF2. The miR-483-3p affects the Wnt/β-catenin, the TGF-β, and the TP53 signaling pathways by targeting several genes as CTNNB1, SMAD4, IGF1, and BBC3. Accordingly, miR-483-3p is associated with various tissues specific physiological properties as insulin and melanin production, as well as with cellular physiological functions such as wounding, differentiation, proliferation, and survival. Deregulation of miR-483-3p is observed in different types of cancer, and its overexpression can inhibit the pro-apoptotic pathway induced by the TP53 target effectors. As a result, the oncogenic characteristics of miR-483-3p are linked to the effect of some of the most relevant cancer-related genes, TP53 and CTNNB1, as well as to one of the most important cancer hallmark: the aberrant glucose metabolism of tumor cells. In this review, we summarize the recent findings regarding the miR-483-3p, to elucidate its functional role in physiological and pathological contexts, focusing overall on its involvement in cancer and in the TP53 pathway.
Nitrogen-Doped Porous Carbon Derived from Bamboo Shoot as Solid Base Catalyst for Knoevenagel Condensation and Transesterification Reactions
Authors: Mi Bingbing , Chen Xiufang , Jiang Changle , Wang Jingxin , Chen Xiujuan , Zhang Bo , Liu Xianmiao , Liu Zhijia , Fei Benhua
Published: June 2018

Highly porous nitrogen-doped carbons derived from bamboo shoots (BSNCs) were prepared through an in-situ synthesis method. The results showed that BSNCs had a large specific surface area, a relatively high nitrogen content and hierarchically porous structures. The catalytic properties of BSNCs were evaluated based on Knoevenagel condensation and transesterification reactions. Deprotonated BSNC-700 exhibited high efficiency for the model reactions as a solid base catalyst, and the superior sample deprotonated in tBuOK solution with a concentration of 0.1 increased the conversion rate from 16.1% to 76.0% for Knoevenagel condensation. The two reactions proceeded smoothly in the presence of deprotonated BSNC-700. The results also showed that the catalyst could be recycled for several times for Knoevenagel condensation. The results from this research will provide a guideline to develop bamboo shoot as a precursor to fabricate a superb solid base catalyst.
Robust Initialization of Rigorous Process Simulations of Multiple Dividing Wall Columns via Vmin Diagrams
Authors: Ränger Lena-Marie , Preißinger Ulrich , Grützner Thomas
Published: June 2018

Dividing Wall Columns (DWCs) allow the separation of a ternary mixture in one column shell by applying a vertical partition wall, yielding a reduction of operational and capital costs of up to 30%. Multiple DWC (mDWC), the consequent advancement of standard DWC, makes use of more than one partitioning wall, allowing the separation of quaternary or even higher mixtures in one column shell accompanied by a further reduction of energy consumption. Since no dedicated models for these columns are available in commercial process simulators, thermodynamic consistent flowsheets have to be designed and implemented. The thermally fully coupled Petlyuk arrangement is one important example. However, the initial convergence of these substituting flowsheets is demanding, since a large number of meaningful initial guesses have to be provided. A promising method for generating these first estimates are minimum vapor (Vmin) diagrams. All internal flows can be extracted from these diagrams and used for robust initialization of the simulation. The goal of this work is to present the Vmin method in a comprehensive way in order to initialize mDWC simulations to predict the separation of four component mixtures. Additionally, the adaptation of the diagram to configurations different than Petlyuk arrangements for mDWC is evaluated and a systematic procedure to obtain them is presented. In the end, an example of a converging simulation is given, which was obtained with the values from the Vmin diagram.