bluuebunny/crossref_metadata_2025 huggingface dataset:
On an Exact Step Length in Gradient-Based Aerodynamic Shape Optimization—Part II: Viscous Flows
Authors: Mohebbi Farzad , Evans Ben , Sellier Mathieu
Published: March 2021

This study presents an extension of a previous study (On an Exact Step Length in Gradient-Based Aerodynamic Shape Optimization) to viscous transonic flows. In this work, we showed that the same procedure to derive an explicit expression for an exact step length βexact in a gradient-based optimization method for inviscid transonic flows can be employed for viscous transonic flows. The extended numerical method was evaluated for the viscous flows over the transonic RAE 2822 airfoil at two common flow conditions in the transonic regime. To do so, the RAE 2822 airfoil was reconstructed by a Bezier curve of degree 16. The numerical solution of the transonic turbulent flow over the airfoil was performed using the solver ANSYS Fluent (using the Spalart–Allmaras turbulence model). Using the proposed step length, a gradient-based optimization method was employed to minimize the drag-to-lift ratio of the airfoil. The gradient of the objective function with respect to design variables was calculated by the finite-difference method. Efficiency and accuracy of the proposed method were investigated through two test cases.
Computational Study of Three-Dimensional Flow Past an Oscillating Cylinder Following a Figure Eight Trajectory
Authors: Peppa Sofia , Kaiktsis Lambros , Frouzakis Christos E. , Triantafyllou George S.
Published: March 2021

The paper presents a computational study of three-dimensional flow past a cylinder forced to oscillate in a uniform stream, following a figure-eight trajectory. Flow simulations were performed for Re = 400, for different cases, defined in terms of the oscillation mode (‘counter-clockwise’ or ‘clockwise’), for values of the ratio, F, of the transverse oscillation frequency to the Strouhal frequency close to 1.0. The results demonstrate that, for F ≤ 1.0, counter-clockwise cylinder motion is associated with positive power transfer from the flow to the cylinder, corresponding to excitation; for the clockwise motion, power transfer is negative at intermediate to high amplitudes, corresponding to damping. For the clockwise mode, in the range F = 0.9–1.1, a transition to two-dimensional vortex street is identified for transverse oscillation amplitude exceeding a critical value. This results from the induced suction of vortices, which moves vortex formation and shedding closer to the cylinder surface, thus resulting in a narrower wake, characterized by an effective lower Reynolds number. Both oscillation modes are characterized by higher harmonics in the lift force spectrum, with the third harmonic being very pronounced, while even harmonics are present for the case of clockwise mode, resulting from a wake transition to a “S + P” mode.
Impact of a Novel Nano-Protectant on the Viability of Probiotic Bacterium Lactobacillus casei K17
Authors: Wang Jinsong , Chen Lanming
Published: March 2021

Probiotics are considered as desirable alternatives to antibiotics because of their beneficial effects on the safety and economy of farm animals. The protectant can ensure the viability of probiotics, which is the prerequisite of the beneficial effects. The objective of this study was to evaluate the effects of a novel nano-protectant containing trehalose, skim milk powder, phytoglycogen nanoparticles, and nano-phytoglycogen Pickering emulsions on the viability of Lactobacillus casei K17 under different conditions. The results indicated that the optimal concentration of the carbohydrate substrate was determined to be 10% skim milk powder (w/w) instead of trehalose. The combination of 10% skim milk powder (w/w), 1% phytoglycogen nanoparticles (w/w), and 10% Pickering emulsions (w/w) was selected as the optimal component of the protectant. Trilayer protectants with an optimal component had a more significant protective effect on the bacteria than that of the monolayer and bilayer protectants, or the control in feed storage, freeze-drying, and simulated gastrointestinal environment. A scanning electron microscope was used to monitor the morphological characteristics of the protectants for different layers on L. casei. In conclusion, the trilayer protectant exhibited a substantial effect on L. casei during storage and consumption, which could be used in the feed and functional food.
Simulation and Non-Invasive Testing of Vinegar Storage Time by Olfaction Visualization System and Volatile Organic Compounds Analysis
Authors: Lin Hao , Lin Jinjin , Song Benteng , Chen Quansheng
Published: March 2021

An olfactory visualization system conducts a qualitative or quantitative analysis of volatile organic compounds (VOCs) by utilizing the sensor array made of color sensitive dyes. The reaction chamber is important to the sensor array’s sufficient and even exposure to VOCs. In the current work, a reaction chamber with an arc baffle embedded in the front of the air inlet for drainage effect was designed. The velocity of field and particle distribution of flow field in the reaction chamber was simulated by COMSOL Multiphysics. Through repeated simulation, the chamber achieved optimal result when the baffle curvature was 3.1 and the vertical distance between the baffle front end and the air inlet was 1.6 cm. Under the new reaction chamber, principal component analysis (PCA) and linear discriminant analysis (LDA) were employed to identify vinegar samples with different storage time through analyzing their VOCs. The LDA model achieved optimal performance when 8 principal components (PCs) were used, and the recognition rate was 95% in both training and prediction sets. The new reaction chamber could improve the stability and precision of an olfactory visualization system for VOCs analysis, and achieve the accurate differentiation and rapid discrimination of Zhenjiang vinegar with different storage time.
Defatted Seeds of Oenothera biennis as a Potential Functional Food Ingredient for Diabetes
Authors: Wang Zhiqiang , Wu Zhaoyang , Zuo Guanglei , Lim Soon Sung , Yan Hongyuan
Published: March 2021

The defatted seeds of Oenothera biennis (DSOB) are a by-product of evening primrose oil production that are currently not effectively used. In this study, α-glucosidase inhibition, aldose reductase inhibition, antioxidant capacity, polyphenol composition, and nutritional value (carbohydrates, proteins, minerals, fat, organic acid, and tocopherols) of DSOB were evaluated using the seeds of Oenothera biennis (SOB) as a reference. DSOB was an excellent inhibitor of α-glucosidase (IC50 = 3.31 μg/mL) and aldose reductase (IC50 = 2.56 μg/mL). DSOB also showed considerable antioxidant capacities (scavenging of 2,2-diphenyl-1-picrylhydrazyl, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid, nitric oxide, peroxynitrite, and hydroxyl radicals). DSOB was a reservoir of polyphenols, and 25 compounds in DSOB were temporarily identified by liquid chromatography coupled with electrospray ionization–quadrupole time of flight–mass spectrometry analysis. Moreover, the carbohydrate, protein, and mineral content of DSOB were increased compared to that of SOB. DSOB contained large amounts of fiber and low levels of sugars, and was rich in calcium and iron. These results imply that DSOB may be a potential functional food ingredient for diabetes, providing excellent economic and environmental benefits.
Repeated Interaction and Its Impact on Cooperation and Surplus Allocation—An Experimental Analysis
Authors: Di Guida Sibilla , Han The Anh , Kirchsteiger Georg , Lenaerts Tom , Zisis Ioannis
Published: March 2021

This paper investigates how the possibility of affecting group composition combined with the possibility of repeated interaction impacts cooperation within groups and surplus distribution. We developed and tested experimentally a Surplus Allocation Game where cooperation of four agents is needed to produce surplus, but only two have the power to allocate it among the group members. Three matching procedures (corresponding to three separate experimental treatments) were used to test the impact of the variables of interest. A total of 400 subjects participated in our research, which was computer-based and conducted in a laboratory. Our results show that allowing for repeated interaction with the same partners leads to a self-selection of agents into groups with different life spans, whose duration is correlated with the behavior of both distributors and receivers. While behavior at the group level is diverse for surplus allocation and amount of cooperation, aggregate behavior is instead similar when repeated interaction is allowed or not allowed. We developed a behavioral model that captures the dynamics observed in the experimental data and sheds light into the rationales that drive the agents’ individual behavior, suggesting that the most generous distributors are those acting for fear of rejection, not for true generosity, while the groups lasting the longest are those composed by this type of distributors and “undemanding” receivers.
Multivariate Analysis Identifies Eight Novel Loci Associated with Meat Productivity Traits in Sheep
Authors: Zlobin Alexander S. , Nikulin Pavel S. , Volkova Natalia A. , Zinovieva Natalia A. , Iolchiev Baylar S. , Bagirov Vugar A. , Borodin Pavel M. , Aksenovich Tatiana I. , Tsepilov Yakov A.
Published: March 2021

Despite their economic value, sheep remain relatively poorly studied animals in terms of the number of known loci and genes associated with commercially important traits. This gap in our knowledge can be filled in by performing new genome-wide association studies (GWAS) or by re-analyzing previously documented data using novel powerful statistical methods. This study is focused on the search for new loci associated with meat productivity and carcass traits in sheep. With a multivariate approach applied to publicly available GWAS results, we identified eight novel loci associated with the meat productivity and carcass traits in sheep. Using an in silico follow-up approach, we prioritized 13 genes in these loci. One of eight novel loci near the FAM3C and WNT16 genes has been replicated in an independent sample of Russian sheep populations (N = 108). The novel loci were added to our regularly updated database increasing the number of known loci to more than 140.
Simultaneous Homozygous Mutations in SLC12A3 and CLCNKB in an Inbred Chinese Pedigree
Authors: Mou Lijun , Wu Fengfen
Published: March 2021

Gitelman syndrome (GS) and Bartter syndrome (BS) type III are both rare, recessively inherited salt-losing tubulopathies caused by SLC12A3 and CLCNKB mutations, respectively. We described a 48-year-old male patient with fatigue, carpopedal spasm, arthralgia, hypokalemic alkalosis, mild renal dysfunction, hypomagnesemia, hypocalciuria, hyperuricemia, normotension, hyperreninemia and chondrocalcinosis in knees and Achilles tendons. His parents are first cousin. Genetic analysis revealed simultaneous homozygous mutations in SLC12A3 gene with c.248G>A, p.Arg83Gln and CLCNKB gene with c.1171T>C, p.Trp391Arg. The second younger brother of the proband harbored the same simultaneous mutations in SLC12A3 and CLCNKB and exhibited similar clinical features except normomagnesemia and bilateral kidney stones. The first younger brother of the proband harbored the same homozygous mutations in CLCNKB and exhibited clinical features of hypokalemia, normomagnesemia, hypercalciuria and hyperuricemia. Potassium chloride, spironolactone and potassium magnesium aspartate were prescribed to the proband to correct electrolytic disturbances. Benzbromarone and febuxostat were prescribed to correct hyperuricemia. The dose of potassium magnesium aspartate was subsequently increased to alleviate arthralgia resulting from calcium pyrophosphate deposition disease (CPPD). To the best of our knowledge, we are the first to report an exceptionally rare case in an inbred Chinese pedigree with simultaneous homozygous mutations in SLC12A3 and CLCNKB. GS and BS type III have significant intrafamilial phenotype heterogeneity. When arthralgia is developed in patients with GS and BS, gout and CPPD should both be considered.
Potential Genetic Contributions of the Central Nervous System to a Predisposition to Elite Athletic Traits: State-of-the-Art and Future Perspectives
Authors: Kitazawa Hiroya , Hasegawa Kazuya , Aruga Daichi , Tanaka Masashi
Published: March 2021

Recent remarkable advances in genetic technologies have allowed for the identification of genetic factors potentially related to a predisposition to elite athletic performance. Most of these genetic variants seem to be implicated in musculoskeletal and cardiopulmonary functions. Conversely, it remains unclear whether functions of the central nervous system (CNS) genetically contribute to elite athletic traits, although the CNS plays critical roles in exercise performance. Accumulating evidence has highlighted the emerging implications of CNS-related genes in the modulation of brain activities, including mental performance and motor-related traits, thereby potentially contributing to high levels of exercise performance. In this review, recent advances are summarized, and future research directions are discussed in regard to CNS-related genes with potential roles in a predisposition to elite athletic traits.
Cognitive Flexibility and Inhibition in Individuals with Age-Related Hearing Loss
Authors: Shende Shraddha A. , Nguyen Lydia T. , Lydon Elizabeth A. , Husain Fatima T. , Mudar Raksha A.
Published: March 2021

Growing evidence suggests alterations in cognitive control processes in individuals with varying degrees of age-related hearing loss (ARHL); however, alterations in those with unaided mild ARHL are understudied. The current study examined two cognitive control processes, cognitive flexibility, and inhibition, in 21 older adults with unaided mild ARHL and 18 age- and education-matched normal hearing (NH) controls. All participants underwent comprehensive audiological and cognitive evaluations including Trail Making Test-B, Verbal Fluency, Stroop, and two Go/NoGo tasks. Group differences in cognitive flexibility and inhibition as well as associations between peripheral and central hearing ability and measures of cognitive flexibility and inhibition were investigated. Findings revealed that the ARHL group took significantly longer to complete the Stroop task and had higher error rates on NoGo trials on both Go/NoGo tasks relative to the NH controls. Additionally, poorer peripheral and central hearing were associated with poorer cognitive flexibility and inhibitory control. Our findings suggest slower and more inefficient inhibitory control in the mild ARHL group relative to the NH group and add to decades of research on the association between hearing and cognition.
Resilience and Euripides’ Heracles
Authors: Pertsinidis Sonia
Published: March 2021

In the midst of the current global health crisis, there is ongoing discussion about the need to cultivate resilience, that is, the ability to survive tragic events, adversity and prolonged stress. This paper engages in a reading of Euripides’ Heracles, a bold and disturbing tragedy in which the eponymous hero suffers several striking reversals of fortune. After being victimized by Hera and unwittingly destroying his family, Heracles resolves to commit suicide. Only two hundred lines later, he resolves to continue to live. This change in outlook is remarkable given the traumatic events that he has just suffered. How does Heracles find the strength to endure? What factors bring about this positive change in Heracles’ perspective? This paper will draw on findings from modern resilience research to shed light on Heracles’ decision. It will discuss the complex combination of internal and external factors that play into Heracles’ change of mind. I argue that the processes that Euripides portrays in his play dramatize many of the protective factors that are said to promote resilience in real life.
Medical Diagnoses, Mode of Residence, and Dental Treatment Demand under General Anesthesia in Special Needs Adults in Innsbruck, Austria. A Retrospective Breakdown of Four and a Half Years
Authors: Schnabl Dagmar , Oberhofer Michael , Barbieri Fabian , Laimer Johannes , Steiner René , Bruckmoser Emanuel , Grunert Ingrid
Published: March 2021

Regarding oral/dental care and attendance, special needs individuals depend on their caregivers’ commitment. The purpose of this retrospective data analysis of adults who received dental general anesthesia (DGA) in Innsbruck, Austria, was a breakdown of demographic parameters (including the mode of accommodation/care), medical diagnoses (comprising intellectual/physical disablement (IPD) or psychiatric (anxiety) disorders (PDs)), and dental therapy performed under DGA. The sample was composed of 233 consecutive adults who underwent DGA from January 2015 to June 2019. Data were analyzed with descriptive and comparative statistics. In total, 133 (57.1%) subjects were male and 100 (42.9%) female; 176 (75.5%) had IPD and 57 (24.5%) PDs; 168 (72.1%) were living at private and 65 (27.9%) at nursing homes. Median age (IQR) was 35.6 (25.7–47.2) years. In the total sample, 5 (2–9) teeth were restored and 2 (0.5–6.5) teeth were extracted. Individuals with PDs had more teeth restored (p = 0.01) and extracted (p < 0.001) than individuals with IPD. Private home residents had more teeth restored (p < 0.001) but less teeth extracted (p = 0.003) than nursing home residents. Special needs individuals’ oral health backlog should be tackled in private and institutional care modalities alike.
Telehealth in Times of COVID-19: Spotlight on Austria
Authors: Kletečka-Pulker Maria , Völkl-Kernstock Sabine , Fassl Anna , Klager Elisabeth , Willschke Harald , Klomfar Sophie , Wochele-Thoma Thomas , Schaden Eva , Atanasov Atanas G.
Published: March 2021

Introduction: With the spread of Coronavirus disease 2019 (COVID-19), the world has been experiencing an extraordinary state of emergency. As patients entering a doctor’s practice can potentially infect medical staff and other patients, using digital alternatives wherever possible is a potential solution to avoiding face-to-face encounters. In these conditions, telemedicine is becoming increasingly relevant. Hence, the aim of this study was to examine telemedicine use and gathered experiences during the COVID-19 pandemic in Austria. Materials and Methods: In June 2020, a representative group of Austrian respondents (n = 1000) was asked via online survey whether they had contacted a doctor during spring of 2020, and, if so, whether they had used a telemedical method to do so. The survey also reflected gathered experiences and degrees of satisfaction with the use of telemedicine. Results: A third (33%) of those who contacted a doctor during the target period did so using telemedical tools. The majority of those with previous telehealth experience were satisfied with the help they received. Patients commonly used a telephone to contact their doctors. The overall assessment of telemedical aids tended to be positive, with more than half (53%) of those surveyed seeing significant advantages, and a 90% satisfaction rate among the respondents who used telehealth services. Conclusion: The outcomes from this work hint at fairly high acceptance of telemedical communication tools in the studied group of the Austrian population. Based on the high rate of satisfaction among patients who used telehealth, it is expected that the use of telehealth services will increase further in the near future.
Multi-Parameter Vital Sign Telemedicine System Using Web Socket for COVID-19 Pandemics
Authors: Pintavirooj Chuchart , Keatsamarn Tanapon , Treebupachatsakul Treesukon
Published: March 2021

Telemedicine has become an increasingly important part of the modern healthcare infrastructure, especially in the present situation with the COVID-19 pandemics. Many cloud platforms have been used intensively for Telemedicine. The most popular ones include PubNub, Amazon Web Service, Google Cloud Platform and Microsoft Azure. One of the crucial challenges of telemedicine is the real-time application monitoring for the vital sign. The commercial platform is, by far, not suitable for real-time applications. The alternative is to design a web-based application exploiting Web Socket. This research paper concerns the real-time six-parameter vital-sign monitoring using a web-based application. The six vital-sign parameters are electrocardiogram, temperature, plethysmogram, percent saturation oxygen, blood pressure and heart rate. The six vital-sign parameters were encoded in a web server site and sent to a client site upon logging on. The encoded parameters were then decoded into six vital sign signals. Our proposed multi-parameter vital-sign telemedicine system using Web Socket has successfully remotely monitored the six-parameter vital signs on 4G mobile network with a latency of less than 5 milliseconds.
Primary School Teachers’ Perspective of Sexual Education in Spain. A Qualitative Study
Authors: Plaza-del-Pino Fernando Jesús , Soliani Isabelle , Fernández-Sola Cayetano , Molina-García Joaquín Jesús , Ventura-Miranda María Isabel , Pomares-Callejón María Ángeles , López-Entrambasaguas Olga María , Ruiz-Fernández María Dolores
Published: March 2021

Sexual education is a part of the teaching-learning process that addresses cognitive, psychological, physical and social aspects of sexuality. The purpose of sexual education is to provide people with knowledge, abilities, attitudes and values that will help them to have good sexual health, well-being and dignity. The objective of this study was to explore the perspective of primary school teachers regarding Sexual Education in school. A descriptive qualitative study was designed based on content thematic analysis. Fifteen open-ended interviews with primary school teachers were carried out, followed by inductive data analysis using ATLAS.ti software. Two key themes emerged from the analysis: “In search of a comprehensive approach to Sexual Education” and “Barriers to Sexual Education in schools: From the lack of training to fear of the families”. We conclude that despite the efforts to implement a comprehensive approach to Sexual Education that recognises sexuality as a right, primary school teachers face difficulties in delivering Sexual Education in schools due to a lack of training and the fear that parents will reject their children being spoken to about sexuality.
COVID-19 Pandemic and Helsinki University Hospital Personnel Psychological Well-Being: Six-Month Follow-Up Results
Authors: Laukkala Tanja , Suvisaari Jaana , Rosenström Tom , Pukkala Eero , Junttila Kristiina , Haravuori Henna , Tuisku Katinka , Haapa Toni , Jylhä Pekka
Published: March 2021

The COVID-19 pandemic has caused an unequally distributed extra workload to hospital personnel and first reports have indicated that especially front-line health care personnel are psychologically challenged. A majority of the Finnish COVID-19 patients are cared for in the Helsinki University Hospital district. The psychological distress of the Helsinki University Hospital personnel has been followed via an electronic survey monthly since June 2020. We report six-month follow-up results of a prospective 18-month cohort study. Individual variation explained much more of the total variance in psychological distress (68.5%, 95% CI 65.2–71.9%) and negative changes in sleep (75.6%, 95% CI 72.2–79.2%) than the study survey wave (1.6%, CI 0.5–5.5%; and 0.3%, CI 0.1–1.2%). Regional COVID-19 incidence rates correlated with the personnel’s psychological distress. In adjusted multilevel generalized linear multiple regression models, potentially traumatic COVID-19 pandemic-related events (OR 6.54, 95% CI 5.00–8.56) and front-line COVID-19 work (OR 1.81, 95% CI 1.37–2.39) was associated with personnel psychological distress but age and gender was not. While vaccinations have been initiated, creating hope, continuous follow-up and psychosocial support is still needed for all hospital personnel.
Associations between Sociodemographic, Dietary, and Substance Use Factors with Self-Reported 24-Hour Movement Behaviors in a Sample of Brazilian Adolescents
Authors: da Costa Bruno Gonçalves Galdino , Chaput Jean-Philippe , Lopes Marcus Vinicius Veber , Malheiros Luis Eduardo Argenta , Silva Kelly Samara da
Published: March 2021

We aimed to identify sociodemographic, dietary, and substance use factors associated with self-reported sleep duration, physical activity (PA), and sedentary behavior (SB) indicators in a sample of Brazilian adolescents. Adolescents (n = 731, 51% female, mean age: 16.4 years) answered a questionnaire. The volume of total PA, sports, non-sports, total SB, leisure-time SB, involuntary SB, sleep duration, dietary behaviors, sociodemographic, and substance use indicators were self-reported. Multilevel linear models were fitted. Females engaged in less total PA, sports, total SB, and leisure-time SB, but in more involuntary SB than males. Age was positively associated with non-sports and involuntary SB. Socioeconomic status was positively associated with total PA. Adolescents who lived with the mother only practiced more sports compared to those living with two parents. Unprocessed food was positively associated with total PA and sports. Processed food was inversely associated with total PA and non-sports, and positively associated with total SB and leisure-time SB. Alcohol use was positively associated with total PA, and tobacco smoking was negatively associated with total PA. No associations were observed for sleep duration. In conclusion, sociodemographic, dietary, and substance use factors are associated with the 24 h movement behaviors among Brazilian adolescents, and some associations are type specific.
Effect of Anti-Rheumatic Treatment on the Periodontal Condition of Rheumatoid Arthritis Patients
Authors: de Smit Menke J. , Westra Johanna , Posthumus Marcel D. , Springer Gerald , van Winkelhoff Arie Jan , Vissink Arjan , Brouwer Elisabeth , Bijl Marc
Published: March 2021

Periodontitis, a bacterial-induced infection of the supporting soft and hard tissues of the teeth (the periodontium), is common in patients with rheumatoid arthritis (RA). As RA and periodontitis underlie common inflammatory pathways, targeting the progression of RA might mediate both periodontitis and RA. On the other hand, patients with RA on immunosuppressive medication have an increased risk of infection. Therefore, the objective of this longitudinal observation study was to assess the effect of methotrexate (MTX) and anti-tumor necrosis factor-α (anti-TNF, etanercept) treatment on the periodontal condition of RA patients. Overall, 14 dentate treatment-naive RA patients starting with MTX and 12 dentate RA patients starting with anti-TNF therapy in addition to MTX were included. Follow-up was scheduled matching the routine protocol for the respective treatments. Prior to the anti-rheumatic treatment with MTX or the anti-TNF therapy in addition to MTX, and during follow-up, i.e., 2 months for MTX, and 3 and 6 months for the anti-TNF therapy in addition to MTX, the periodontal inflamed surface area (PISA) was measured. The efficacy of the anti-rheumatic treatment was assessed by determining the change in RA disease activity (DAS28-ESR). Furthermore, the erythrocyte sedimentation rates were determined and the levels of C-reactive protein, IgM-rheumatoid factor, anti-cyclic citrullinated protein antibodies, and antibodies to the periodontal pathogen Porphyromonas gingivalis, were measured. Subgingival sampling and microbiological characterization of the subgingival microflora was done at baseline. MTX or anti-TNF treatment did not result in an improvement of the periodontal condition, while both treatments significantly improved DAS28 scores (both p < 0.01), and reduced C-reactive protein levels and erythrocyte sedimentation rates (both p < 0.05). It is concluded that anti-rheumatic treatment (MTX and anti-TNF) has negligible influence on the periodontal condition of RA patients.
Reply to Comment on Tsai, Y.-C., et al. Association of Stress-Induced Hyperglycemia and Diabetic Hyperglycemia with Mortality in Patients with Traumatic Brain Injury: Analysis of a Propensity Score-Matched Population. Int. J. Environ. Res. Public Health 2020, 17, 4266
Authors: Tsai Yu-Chin , Wu Shao-Chun , Hsieh Ting-Min , Liu Hang-Tsung , Huang Chun-Ying , Chou Sheng-En , Su Wei-Ti , Hsu Shiun-Yuan , Hsieh Ching-Hua
Published: March 2021

Thank you for Eduardo Mekitarian Filho’s appreciation of our work on the study of stress-induced hyperglycemia (SIH) and diabetic hyperglycemia (DH) in patients with traumatic brain injuries [...]
‘Dr. Google, What Is That on My Skin?’—Internet Searches Related to Skin Problems: Google Trends Data from 2004 to 2019
Authors: Kamiński Mikołaj , Tizek Linda , Zink Alexander
Published: March 2021

The Internet is a common source of health information as search engines propose websites that should answer users’ queries. The study aimed to investigate the search behavior of Google users related to skin clinical signs as well as to analyze their geographical, secular, and seasonal patterns. The data of Google Trends was used to analyze the number of Google searches related to skin problems from January 2004 to December 2019. Thirty-four topics representing dermatologic complaints were identified. The interests of all topics were calculated in proportion to the Relative Search Volume (RSV) of ‘Scar’. Geographical patterns as well as secular and seasonal trends were analyzed. Countries with few users who searched for skin problems were excluded from the analysis. Globally, gaining the most attention were ‘Itch’ proportion to RSV of ‘Itch’ (2.21), ‘Hair loss’ (1.56), ‘Skin rash’ (1.38), ‘Perspiration’ (1.32), and ‘Scar’ (1.00). In 42 of the 65 analyzed countries, ‘Itch’ was the most popular topic, followed by ‘Hair loss’ (n = 7), and ‘Pustule’ (n = 6). The RSV of all topics increases over time, with ‘Comedo’ (5.15 RSV/year), ‘Itch’ (4.83 RSV/year), and ‘Dandruff’ (4.66 RSV/year) being the most dynamic ones. For 23 topics, the highest interest was noted during warm months. Considering skin manifestations, Google users are mainly interested in itch, hair loss, and skin rash. An increasing number of individuals worldwide seem to use Google as a source of health information for dermatological clinical signs during the study period.
The Impact of Collaboration Network on Water Resource Governance Performance: Evidence from China’s Yangtze River Delta Region
Authors: Yi Hongtao , Yang Yan , Zhou Chao
Published: March 2021

Existing studies rarely examine the relationship between network structure and network performance. To fill this research gap, this article collects inter-local collaboration network data from 41 cities in the Yangtze River Delta region of China from 2009 to 2015. Based on the institutional collective action framework and social capital theory, we propose bridging and bonding hypotheses regarding the impact of network structures on governance performance. We employ social network analysis and panel data regression models to test the hypotheses. The results show that the coefficients for closeness centrality and clustering coefficient are statistically significant in this analysis, Wuxi played a central role in the collaboration network and the region had formed a close partner network, confirming the positive effect of bridging and bonding network social capital structures on network performance.
MAternal Mental Health in the WORKplace (MAMH@WORK): A Protocol for Promoting Perinatal Maternal Mental Health and Wellbeing
Authors: Costa Joana , Santos Osvaldo , Virgolino Ana , Pereira M. Emília , Stefanovska-Petkovska Miodraga , Silva Henrique , Navarro-Costa Paulo , Barbosa Miguel , das Neves Rui César , Duarte e Silva Inês , Alarcão Violeta , Vargas Ricardo , Heitor Maria João
Published: March 2021

Women are exposed to increased burden of mental disorders during the perinatal period: 13–19% experience postpartum depression. Perinatal psychological suffering affects early mother-child relationship, impacting child’s emotional and cognitive development. Return-to-work brings additional vulnerability given the required balance between parenting and job demands. The MAternal Mental Health in the WORKplace (MAMH@WORK) project aims to develop and evaluate the effectiveness of a brief and sustainable intervention, promoting (a) maternal mental health throughout pregnancy and first 12 months after delivery, and (b) quality of mother–child interactions, child emotional self-regulation, and cognitive self-control, while (c) reducing perinatal absenteeism and presenteeism. MAMH@WORK is a three-arm randomized controlled trial. A short-term cognitive-behavioral therapy-based (CBT-based) psychoeducation plus biofeedback intervention will be implemented by psychiatrists and psychologists, following a standardized procedure manual developed after consensus (Delphi method). Participants (n = 225, primiparous, singleton pregnant women at 28–30 weeks gestational age, aged 18–40 years, employed) will be randomly allocated to arms: CBT-based psychoeducation intervention (including mindfulness); psychoeducation plus biofeedback intervention; and control. Assessments will take place before and after delivery. Main outcomes (and main tools): mental health literacy (MHLS), psychological wellbeing (HADS, EPDS, KBS, CD-RISC, BRIEF COPE), quality of mother–child interaction, child–mother attachment, child emotional self-regulation and cognitive self-control (including PBQ, Strange Situation Procedure, QDIBRB, SGS-II, CARE-Index), job engagement (UWES), and presenteeism. Intention-to-treat and per-protocol analyses will be conducted; Cohen’s d coefficient, Cramer’s V and odds ratio will be used to assess the effect size of the intervention. MAMH@WORK is expected to contribute to mental health promotion during the perinatal period and beyond. Its results have the potential to inform health policies regarding work–life balance and maternal mental health and wellbeing promotion in the workplace.
Melatonin Supplementation for Six Weeks Had No Effect on Arterial Stiffness and Mitochondrial DNA in Women Aged 55 Years and Older with Insomnia: A Double-Blind Randomized Controlled Study
Authors: Kim Yonghwan , Kang Hee-Taik , Lee Duk-Chul
Published: March 2021

Melatonin is a hormone produced in the pineal gland that controls sleep and circadian rhythm. Some studies have reported antioxidant and anti-inflammatory effects of melatonin that could benefit cardiometabolic function; however, there is a lack of evidence to support these assertions. The aim of this study was to investigate whether melatonin has beneficial effects on arterial stiffness and mitochondrial deoxyribonucleic acid (DNA) in humans. Methods: This study was designed as a double-blind randomized controlled study. Thirty-eight healthy women aged 55 years and older were enrolled. All had insomnia (Pittsburgh Sleep Quality Index (PSQI) ≥ 5), not treated with any medications, for at least three months before enrollment. Subjects were divided into a melatonin and a placebo group according to melatonin supplementation. The melatonin group took 2 mg melatonin every night for six weeks. The cardio–ankle vascular index (CAVI) was used as an indicator of arterial stiffness. After six weeks, CAVI, mitochondrial DNA (mtDNA) copy number in white blood cells (WBCs), and other metabolic indices, such as homeostasis model assessment of insulin resistance (HOMA-IR), were checked. Results: Sleep quality index using PSQI was improved in the melatonin group from a score of 11 to 8 (p = 0.01), but did not change significantly in the control group. However, there was no significant intergroup difference in PSQI. Systolic blood pressure (SBP) decreased in the melatonin group from 135 to 128 mmHg (p = 0.015), while remaining stable in the placebo group. Right CAVI, mitochondrial DNA copy number, and HOMA-IR were not altered in either group. There were no intergroup differences in CAVI, mtDNA, HOMA-IR, or SBP between baseline and week six. Conclusions: We found no evidence that melatonin supplementation improved cardiometabolic parameters like arterial stiffness, mtDNA, or insulin resistance compared to the placebo between baseline and week six. Sleep quality was improved in the melatonin group. Further research, including longer-term studies with higher doses of melatonin, is warranted.
Analysis on the Spatial-Temporal Evolution Characteristics and Spatial Network Structure of Tourism Eco-Efficiency in the Yangtze River Delta Urban Agglomeration
Authors: Sun Yiyang , Hou Guolin
Published: March 2021

Based on the panel data of 41 cities in the Yangtze River Delta from 2008 to 2017, this paper constructs an evaluation indicators system for urban tourism eco-efficiency. By measuring the tourism eco-efficiency in the Yangtze River Delta urban agglomeration, we analyze its spatial-temporal evolution characteristics. Furthermore, the modified gravity model and social network analysis are introduced to explore the spatial network structure of tourism eco-efficiency and its evolution trend.The results show that:(1) The overall eco-efficiency of tourism in the Yangtze River Delta region presents a fluctuating downward trend, among which Jiangsu and Zhejiang have high eco-efficiency, Shanghai and Anhui are relatively low. The gap within the region first increased and then decreased. (2) During this decade, the spatial network structure of tourism eco-efficiency in the Yangtze River Delta has become increasingly loose. The weakening of the network connection strength has led to a decrease in the regional tourism eco-efficiency to a great extent. (3) The network centrality of cities such as Zhoushan, Huzhou, and Huangshan has always maintained a high level, and these cities have firmly occupied the core position of network. (4) The spatial association network of tourism eco-efficiency can be divided into four blocks: “two-way spillover”, “net spillover”, “net benefit” and “agent”. The synergy and spillover effect between various blocks are significant, and there is a spatial polarization trend centered on a few cities. Based on this, this paper puts forward optimization suggestions for the spatial network structure of the Yangtze River Delta urban agglomeration, in anticipation of promoting the improvement of regional tourism eco-efficiency.
Visual Parameters and Retinal Morphology for Polypoidal Choroidal Vasculopathy Pre- and Post-Intravitreal Ranibizumab with or without Photodynamic Therapy: A Short-Term Prospective Study
Authors: Ghoshal Rituparna , Sharanjeet-Kaur Sharanjeet , Fadzil Norliza Mohamad , Ghosh Somnath , Ngah Nor Fariza , Aziz Roslin Azni Binti Abd
Published: March 2021

The objective of this study was to compare visual parameters and retinal layers’ morphology pre-treatment (baseline) and 6 months post-treatment in polypoidal choroidal vasculopathy (PCV) eyes. A single centre, longitudinal, prospective study was conducted at a public tertiary hospital of Malaysia. Visual parameters including distance and near visual acuity (DVA and NVA), contrast sensitivity (CS), reading speed (RS), and different qualitative and quantitative optical coherence tomography (OCT) parameters were evaluated pre- and 6 months post-treatment. Thirty-three naïve PCV eyes of 32 patients (mean age of 67.62 years) were evaluated pre- and post-treatment of intravitreal ranibizumab with and without photodynamic therapy. After treatment, sub retinal fluid decreased from 27 eyes (84.35%) at baseline to 7 eyes (21.88%) at 6 months while pigment epithelium detachment decreased from 32 eyes (100%) at base line to 15 eyes (46.87%) at 6 months. Mean pre-treatment quantitative morphological OCT retinal parameters including thickness and volume of central sub field, center thickness, center minimum, and maximum thickness reduced significantly. Similarly, all visual parameters including DVA, NVA, CS, and RS showed statistically significant improvement. While 89% of the eyes showed improvement in CS, 78%, 71%, and 65% of the eyes showed improvement in NVA, RS, and DVA, respectively. Thus, CS was the most treatment responsive visual parameter.
Psychometric Properties of the Malay Version of the Internet Gaming Disorder Scale-Short Form (IGDS9-SF-M): Evidence from a Sample of Malaysian Undergraduates
Authors: Ling Shiao Ling , Nik Jaafar Nik Ruzyanei , Tan Kit-Aun , Bahar Norharlina , Baharudin Azlin , Ahmad Tajjudin Ahmad Izzat
Published: March 2021

In recent years, increased interest in Internet Gaming Disorder has led to the development of the Internet Gaming Disorder Scale-Short Form. Translation and subsequent validation of such a scale are important for cross-cultural use. The aim of the present study was to examine the psychometric properties (factor structure, reliability, and validity) of the Malay Version of the Internet Gaming Disorder Scale-Short Form using a sample of Malaysian undergraduates. The present sample included 137 Malaysian undergraduates. Participants completed a self-administered online survey containing demographic items, the Malay Version of the Internet Gaming Disorder Scale-Short Form, the Problematic Online Gaming Questionnaire-Short Form, and the Malay Version of the Internet Addiction Test. The present findings confirm the one-factor model of the Malay Version of the Internet Gaming Disorder Scale-Short Form. Good reliability, as measured by Cronbach alpha, was found for the Malay Version of the Internet Gaming Disorder Scale-Short Form. The Malay Version of the Internet Gaming Disorder Scale-Short Form has demonstrated concurrent validity by significantly correlating with the Problematic Online Gaming Questionnaire-Short Form as well as demonstrated convergent validity with respect to the Malay Version of the Internet Addiction Test. The Malay Version of the Internet Gaming Disorder Scale-Short Form is a reliable and valid tool for assessing Internet Gaming Disorder in Malaysian undergraduates. As more research is still needed to confirm the status of Internet Gaming Disorder as a formal disorder, it is hoped that the Malay Version of the Internet Gaming Disorder Scale-Short Form can facilitate future research examining antecedents and consequences of Internet Gaming Disorder in a Malaysian setting.
Post-Traumatic Stress Disorder in the Military Police of Rio de Janeiro: Can a Risk Profile Be Identified?
Authors: Dias Campos Fernanda , Chambel Maria José , Lopes Sílvia , Dias Paulo C.
Published: March 2021

Background: Significant exposure to critical incidents characteristic of military police work has a potentially traumatic effect and multiple consequences for the mental health of these professionals, such as Post Traumatic Stress Disorder (PTSD). This study aims to investigate the occurrence of PTSD in this occupational group and its correlations with socio-demographic and occupational variables. Methods: This is a cross-sectional study of Rio de Janeiro’s Military Police officers (n = 3.577). Data was collected from self-reported questionnaires applied in an institutional health program. Post-Traumatic Stress Disorder Checklist—Civilian version was used to assess PTSD. Results: Rates of 16.9% for full PTSD and 26.7% for partial PTSD were found. Based on logistic regression analysis, female officers and police officers in lower ranks of the military hierarchy and performing administrative duties were found to be at most risk of developing PTSD. Conclusions: These results suggest the need to further understand the predictive organizational and individual variables of PTSD correlated with the increased vulnerability of professionals in order to contribute to institutional policies for the prevention and rehabilitation of these cases.
Changes in Six-Month Prevalence of Circulatory System Diseases among People Aged 20 Years and Older between 2013 and 2018 in Hunan, China
Authors: Rao Zhenzhen , Hua Junjie , Li Ruotong , Fu Yanhong , Li Jie , Xiao Wangxin , He Jieyi , Hu Guoqing
Published: March 2021

Recent changes in population-based prevalence for circulatory system diseases (CSDs) remain unreported either nationally or locally for China. Data were from the two-round health service household interview survey of Hunan Province, China, in 2013 and 2018. A Rao–Scott chi-square test was performed to examine prevalence differences across socio-demographic variables. The overall age-standardized prevalence of CSDs increased substantially between 2013 and 2018 for inhabitants aged 20 years and older (14.25% vs. 21.25%; adjusted odds ratio (OR) = 1.59, 95% CI: 1.24–2.04). Hypertensive disease was the most prevalent type of CSD, accounting for 87.24% and 83.83% of all CSDs in 2013 and in 2018, respectively. After controlling for other socio-demographic factors, the prevalence of CSDs was significantly higher in 2018 (adjusted OR = 1.40), urban residents (adjusted OR = 1.43), females (adjusted OR = 1.12) and older age groups (adjusted OR = 5.36 for 50–59 years, 9.51 for 60–69 years, 15.19 for 70–79 years, and 12.90 for 80 years and older) than in 2013, rural residents, males and the youngest age group (20–49 years). The recent increase in the overall age-standardized CSD prevalence and the large prevalence disparities across urban/rural residents, sex and age groups merit the attention of policymakers and researchers. Further prevention efforts are needed to curb the increasing tendency and to reduce the prevalence of disparities across socio-demographic groups.
Lived Experience Related to the COVID-19 Pandemic among Arabic-, Russian- and Somali-Speaking Migrants in Finland
Authors: Finell Eerika , Tiilikainen Marja , Jasinskaja-Lahti Inga , Hasan Nasteho , Muthana Fairuz
Published: March 2021

Increasing research shows that migrants are disproportionately exposed to coronavirus disease 2019 (COVID-19). However, little is known about their lived experience and related meaning-making. This qualitative study maps COVID-19-related experiences among respondents from three migrant groups living in Finland: Somali-, Arabic- and Russian-speakers (N = 209). The data were collected by telephone interviews over four weeks in March and April 2020. Using inductive thematic analysis, we identified seven themes that illustrate respondents’ multifaceted lived experiences during the first phase of pandemic. The themes depict respondents’ difficulties and fears, but also their resilience and resources to cope, both individually and collectively. Experiences varied greatly between individuals and migrant groups. The main conclusion is that although the COVID-19 pandemic may be an especially stressful experience for migrant populations, it may also provide opportunities to deepen cooperation and trust within migrant communities, and between migrants and their country of settlement. Our analysis suggests that cooperation between local authorities and migrants, trust-building and effective information-sharing can foster positive and functional adaptations to disease-related threats and changing social environments.