bluuebunny/crossref_metadata_2025 huggingface dataset:
CircRNA circ-0110102 Function as Anti-oncogenic Gene in Hepatocellular Carcinoma through Modulating miR-580-5p/CCL2 Pathway
Authors: Wang Xinxing , Sheng Wei , Xu Tao , Xu Jiawen , Chen Juntao , Rong Zhonghou , Wang Zhiyi , Du Dongdong , Wang Yadong , Gao Ruyi , Zhang Zhenhai
Published: July 2020

Background

Circular RNAs (circRNAs) have been shown to have critical regulatory roles in tumor biology, whereas their contributions in hepatocellular carcinoma (HCC) still remains enigmatic. The purpose of this study was to investigate the molecular mechanisms involved in hsa_circ_0110102 in the occurrence and development of HCC.
Results

hsa_circ_0110102 was significantly down-regulated in HCC cell lines and tissues, low hsa_circ_0110102 expression levels were associated with poor prognosis. Knockdown hsa_circ_0110102 significantly inhibited cell proliferation, migration and invasion. In addition, the interaction between hsa_circ_0110102 and miR-580-5p was predicted and verified by luciferase assay and RNA pull-down, indicating that hsa_circ_0110102 function as sponge of miR-580-5p. Moreover, miR-580-5p which could directly bind to the 3’-UTR of CCL2 and induce its expression, then active the COX-2/PGE2 pathway in macrophage via FoxO1 in p38 MAPK dependent manner. Furthermore, the Δ256 mutant of FoxO1 showed no activation effect. These results concluded that hsa_circ_0110102 act as a sponge for miR-580-5p and decreased CCL2 secretion in HCC cells, then inhibits pro-inflammatory cytokine release from activated macrophage by regulating the COX-2/PGE2 pathway.
Conclusions

These results indicating that hsa_circ_0110102 serves as a potential prognostic predictor or therapeutic target for HCC.
Peripheral blood occludin level as a biomarker for preoperative cerebral edema in patients with brain tumors
Authors: Shi Shu-hai , Cheng Jing-li , Zhang Chun-yang , Liang Tao , Zhang Yun-xin , Sun Yong-xing , Zhao Ying , Li Wei-li , Wang Bao-guo
Published: July 2020

ObjectiveCerebral edema is a common complication of brain tumors in the perioperative period. However, there is currently no reliable and convenient method to evaluate the extent of brain edema. The objective of this study is to explore the ability of serum occludin level to predict the extent of perioperative brain edema and outcome in patients with brain tumors.MethodsThis prospective study enrolled 55 patients with brain tumors and 24 healthy controls from Sanbo Brain Hospital from June 2019 through November 2019. Serum occludin level was measured preoperatively and on postoperative day 1. Peritumoral edema was assessed preoperatively using magnetic resonance imaging. Pericavity brain edema on postoperative day 1 was evaluated using computed tomography.ResultsCompared with healthy controls, serum occludin level was higher in patients with brain tumors both preoperatively and postoperatively (P < 0.001). Serum occludin level was significantly positively correlated with the extent of brain edema preoperatively (r = 0.78, P < 0.001) and postoperatively (r = 0.59, P < 0.001). At an optimal cutoff of 3.015 ng/mL, preoperative serum occludin level discriminated between mild and severe preoperative brain edema with a sensitivity of 90.48% and a specificity of 84.62%. At an optimal cutoff value of 3.033 ng/mL, postoperative serum occludin level distinguished between mild and severe postoperative brain edema with a sensitivity of 97.30% and a specificity of 55.56%. ConclusionsSerum occludin level is associated with cerebral edema and could potentially be used as a biomarker for perioperative cerebral edema.
Canadian Emergency Medicine and Critical Care Physician Perspectives on Pandemic Triage in COVID-19
Authors: Mulla Ali , Bigham Blair L. , Frolic Andrea , Christian Michael D.
Published: July 2020

Purpose: Local and regional policies to guide the allocation of scarce critical care resources have been developed, but the views of prospective users are not understood. We sought to investigate the perspectives of Canadian acute care physicians towards triaging scarce critical care resources in the COVID-19 pandemic. Methods: We rapidly deployed a brief survey to Canadian emergency and critical care physicians in April 2020 to investigate current attitudes towards triaging scarce critical care resources and identify subsequent areas for improvement. Descriptive and between-group analyses along with thematic coding were used.Results: The survey was completed by 261 acute care physicians. Feelings of anxiety related to the pandemic were common (65%), as well as fears of psychological distress if required to triage scarce resources (77%). Only 49% of respondents felt confident in making resource allocation decisions. Both critical care and emergency physicians favored multidisciplinary teams over single physicians to allocate scarce critical care resources. Critical care physicians were supportive of decision making by teams not involved in patient care (3.4/5 vs 2.9/5 p=0.04), whereas emergency physicians preferred to maintain their involvement in such decisions (3.4/5 vs 4.0/5 p=0.007). Free text responses identified five themes for subsequent action including the need for further guidance on existing triage policies, ethical support in decision making, medico-legal protection, additional tools for therapeutic communications, and healthcare provider psychological support. Conclusion: There is an urgent need for collaboration between policymakers and frontline physicians to develop critical care resource triage policies that wholly consider the diversity of provider perspectives across practice environments.
Ammonium removal of biological roughing filter for rural drinking water pretreatment
Authors: Zeng Jie , Chabi Kassim , Hu Yue , Zhang Shenghua , Yu Xin
Published: July 2020

Ammonium pollution of source water has become a challenge in rural water supply. Biological roughing filtration combining with low energy consumption and simple operation would be a potential solution to this issue. This study was conducted to investigate ammonium removal by biological up-flow roughing filter packed with ceramic media. Low flow rate did affect the ammonium removal and higher flow rate was suggested, while intense backwashing only showed a slight impact. At 4 m/h, an average reduction of about 51% was obtained, and NH4+-N effluent concentration could be below 0.5 mg/L within a NH4+-N loading rate of 0.1 kg/(m3·d). Biomass and biological activity assessment were performed as well as microbial community analysis. High abundance of nitrifying bacteria contributed to ammonium removal with Nitrospira and Nitrosomonas accounting for 6.59% and 1.12% of the bacteria community, respectively. In addition, the roughing filter showed high turbidity removal efficiency of about 70%. This study suggested that a biological roughing filter could be employed to help rural drinking water plants adapt to the seasonal change and moderate deterioration of source water quality in terms of ammonium pollution with low-cost and simple operation.
¿Incide la ISO 14000 en el desempeño exportador de las empresas colombianas?
Authors: García-Castiblanco Claudia Paola , Díaz-Ariza Diana Marcela , Pinzón-Muñoz Carlos Andrés
Published: July 2020

Los sistemas de gestión ambiental, como los que certifica la Organización Internacional para la Estandarización - ISO 14000, buscan garantizar el buen manejo de los recursos en las empresas, de forma tal que se establezcan prácticas amigables con el ambiente. Son diversas las razones que pueden motivar a las empresas a desarrollar procesos de certificación, como poder cumplir con estándares internacionales y de esta manera acceder a mercados en el extranjero. Siendo Colombia uno de los países en los que más se ha incrementado la adopción de la certificación ISO 14000, vale la pena peguntar si este proceso les genera a las compañías un aumento en el volumen de sus exportaciones. Esta investigación se realiza en el marco de la teoría de la competitividad ambiental. El estudio es de corte transversal e identifica empresas certificadas y que además son exportadoras, midiendo su comportamiento frente a un grupo de compañías no certificadas mediante una prueba de hipótesis no paramétrica. Como resultado se encuentra que existe una diferencia significativa entre los volúmenes exportados por las empresas certificadas y los de las que no lo están, aunque no se puede afirmar que su éxito en ventas en el extranjero se deba a la ISO 14000.
Estimación del costo económico del homicidio en el municipio de San José de Cucúta 2010-2017
Authors: Zambrano-Miranda Mario de Jesús , Pinzón-Solano Chanberlayn , Pontón-Álvarez Marcela
Published: July 2020

El presente artículo tiene como finalidad establecer una estimación del costo del homicidio en el municipio de San José de Cúcuta, tomando como método de estimación la jurisprudencia sobre reparación directa para establecer el costo de una vida perdida, partiendo inicialmente de la revisión de cifras oficiales de la Policía Nacional (PONAL) sobre el homicidio, desarrollando un análisis descriptivo con el uso de la bioestadística, para exponer la perdida de años por causa del asesinato arrojando así una mirada humana frente a los datos, además del uso de la cartografía con la cual se logra evidenciar las interacciones en el territorio entre comunas y estratos sociales, es evidente que el principal sitio de ocurrencia de los hechos son los espacios públicos, pero las mujeres en comparación con los hombres padecen en mayor medida homicidios en espacios privados, la mayor afectación se da en las personas más jóvenes teniendo una connotación económica fuerte ya que se da en la edad más productiva, de igual forma es necesario generar políticas públicas más acertadas para atender este problema, basada en los datos y conocimiento.
One Pot Enzyme-Catalyzed Cascade Benefit Systems
Authors: Jiang Chengjun , Cheng Guilin , Xu Fan , Wu Qi
Published: July 2020

Enzyme-catalyzed cascade reactions have attracted an increasing attention with many advantages,
such as environmental protection, high efficiency and no need for intermediate purification.
The present overview has summarized enzymatic cascade benefit systems, including double-enzyme,
multi-enzyme, and chemical-enzyme catalytic one-pot reactions. With the continuous developments
in protein engineering, metabolic engineering, synthetic biology and systems biocatalysis, multi-step
biotransformations will expand the scope of application, as well as enhance the biocatalytic efficiency.
Antibody-Based Targeted Interventions for the Diagnosis and Treatment of Skin Cancers
Authors: Madheswaran Suresh , Mungra Neelakshi , Biteghe Fleury A.N. , De la Croix Ndong Jean , Arowolo Afolake T. , Adeola Henry A. , Ramamurthy Dharanidharan , Naran Krupa , Khumalo Nonhlanhla P. , Barth Stefan
Published: July 2020

Background:

Cutaneous malignancies most commonly arise from skin epidermal cells. These cancers may rapidly progress from benign to a metastatic phase. Surgical resection represents the gold standard therapeutic treatment of non-metastatic skin cancer while chemo- and/or radiotherapy are often used against metastatic tumors. However, these therapeutic treatments are limited by the development of resistance and toxic side effects, resulting from the passive accumulation of cytotoxic drugs within healthy cells.

Objective:

This review aims to elucidate how the use of monoclonal Antibodies (mAbs) targeting specific Tumor Associated Antigens (TAAs) is paving the way to improved treatment. These mAbs are used as therapeutic or diagnostic carriers that can specifically deliver cytotoxic molecules, fluorophores or radiolabels to cancer cells that overexpress specific target antigens.

Results:

mAbs raised against TAAs are widely in use for e.g. differential diagnosis, prognosis and therapy of skin cancers. Antibody-Drug Conjugates (ADCs) particularly show remarkable potential. The safest ADCs reported to date use non-toxic photo-activatable Photosensitizers (PSs), allowing targeted Photodynamic Therapy (PDT) resulting in targeted delivery of PS into cancer cells and selective killing after light activation without harming the normal cell population. The use of near-infrared-emitting PSs enables both diagnostic and therapeutic applications upon light activation at the specific wavelengths.

Conclusion:

Antibody-based approaches are presenting an array of opportunities to complement and improve current methods employed for skin cancer diagnosis and treatment.
Влияние топографических дефектов на супергидрофобные свойства покрытий на основе ZnO
Authors: Муслимов А.Э. , Асваров А.Ш. , Шабанов Н.C. , Каневский В.М.
Published: July 2020

Results of investigation of hydrophobic properties of ZnO coating with different surface morphology are given. It was shown that for the case of ZnO samples with surface roughness in the nanometer range, the Wenzel state is realized, and for microstructured samples - the Сassie state. For a sample with multimodal surface roughness, a superhydrophobic state was achieved with an edge angle of 151 ° and an adhesion operation of 8.82 mJ/m2. It has been demonstrated that the presence of micrometer defects on the surface of superhydrophobic samples leads to instability of the Сassie state, and as the radius of water drops increases, the Сassie-Wenzel transition is realized.
Изопериодические гетероструктуры Ga-=SUB=-x-=/SUB=-In-=SUB=-1-x-=/SUB=-Sb-=SUB=-y-=/SUB=-As-=SUB=-z-=/SUB=-P-=SUB=-1-y-z-=/SUB=-/InP для планарных p-n-фотодиодов
Authors: Лунина М.Л. , Лунин Л.С. , Алфимова Д.Л. , Пащенко А.С. , Пащенко О.С.
Published: July 2020

Isoperiodic heterostructures GaxIn1-xSbyAszP1-y-z/InP at a 1.06 to 1.6 μm wavelength interval were grown by the method of floating-zone recrystallization with temperature gradient. Absolute spectral sensitivity of ~ 0.59 A/W and a speed of ~ 10 ns were achieved. Threshold sensitivity for the fabricated photodiodes was in the range 2·10^-10 to 5·10^-11 W with a signal-to-noise ratio of 10.
Analysis of Diabetes Apps to Assess Privacy-Related Permissions: Systematic Search of Apps
Authors: Flors-Sidro José Javier , Househ Mowafa , Abd-Alrazaq Alaa , Vidal-Alaball Josep , Fernandez-Luque Luis , Sanchez-Bocanegra Carlos Luis
Published: July 2020

Background

Mobile health has become a major vehicle of support for people living with diabetes. Accordingly, the availability of mobile apps for diabetes has been steadily increasing. Most of the previous reviews of diabetes apps have focused on the apps’ features and their alignment with clinical guidelines. However, there is a lack of knowledge on the actual compliance of diabetes apps with privacy and data security guidelines.

Objective

The aim of this study was to assess the levels of privacy of mobile apps for diabetes to contribute to the raising of awareness of privacy issues for app users, developers, and governmental data protection regulators.

Methods

We developed a semiautomatic app search module capable of retrieving Android apps’ privacy-related information, particularly the dangerous permissions required by apps, with the aim of analyzing privacy aspects related to diabetes apps. Following the research selection criteria, the original 882 apps were narrowed down to 497 apps that were included in the analysis.

Results

Approximately 60% of the analyzed diabetes apps requested potentially dangerous permissions, which pose a significant risk to users’ data privacy. In addition, 28.4% (141/497) of the apps did not provide a website for their privacy policy. Moreover, it was found that 40.0% (199/497) of the apps contained advertising, and some apps that claimed not to contain advertisements actually did. Ninety-five percent of the apps were free, and those belonging to the “medical” and “health and fitness” categories were the most popular. However, app users do not always realize that the free apps’ business model is largely based on advertising and, consequently, on sharing or selling their private data, either directly or indirectly, to unknown third parties.

Conclusions

The aforementioned findings confirm the necessity of educating patients and health care providers and raising their awareness regarding the privacy aspects of diabetes apps. Therefore, this research recommends properly and comprehensively training users, ensuring that governments and regulatory bodies enforce strict data protection laws, devising much tougher security policies and protocols in Android and in the Google Play Store, and implicating and supervising all stakeholders in the apps’ development process.
Visual and Personalized Quality of Life Assessment App for People With Severe Mental Health Problems: Qualitative Evaluation
Authors: Buitenweg David , van de Mheen Dike , Grund Jean-Paul , van Oers Hans , van Nieuwenhuizen Chijs
Published: July 2020

Background

QoL-ME is a digital visual personalized quality of life assessment app for people with severe mental health problems. Research reveals that e-mental health apps frequently suffer from low engagement and fall short of expectations regarding their impact on patients’ daily lives. Studies often indicate that e-mental health apps ought to respect the needs and preferences of end users to achieve optimal user engagement.

Objective

The aim of this study was to explore the experiences of users regarding the usability and functionality of QoL-ME and whether the app is actionable and beneficial for patients.

Methods

End users (n=8) of QoL-ME contributed to semistructured interviews. An interview guide was used to direct the interviews. All interviews were audiorecorded and transcribed verbatim. Transcriptions were analyzed and coded thematically.

Results

Analysis revealed 3 main themes: (1) benefit, (2) actionability, and (3) characteristics of the QoL-ME. The first theme reveals that the QoL-ME app was beneficial for the majority of respondents, primarily by prompting them to reflect on their quality of life. The current version is not yet actionable; the actionability of the QoL-ME app may be improved by enabling users to view their scores over time and by supplying practical advice for quality of life improvements. Overall, participants had positive experiences with the usability, design, and content of the app.

Conclusions

The QoL-ME app can be beneficial to users as it provides them with insight into their quality of life and elicits reflection. Incorporating more functionalities that facilitate self-management, such as advice and strategies for improving areas that are lacking, will likely make the app actionable. Patients positively regarded the usability, design, and contents of the QoL-ME app.
Artificial Intelligence in the Fight Against COVID-19: Scoping Review
Authors: Abd-Alrazaq Alaa , Alajlani Mohannad , Alhuwail Dari , Schneider Jens , Al-Kuwari Saif , Shah Zubair , Hamdi Mounir , Househ Mowafa
Published: July 2020

Background

In December 2019, COVID-19 broke out in Wuhan, China, leading to national and international disruptions in health care, business, education, transportation, and nearly every aspect of our daily lives. Artificial intelligence (AI) has been leveraged amid the COVID-19 pandemic; however, little is known about its use for supporting public health efforts.

Objective

This scoping review aims to explore how AI technology is being used during the COVID-19 pandemic, as reported in the literature. Thus, it is the first review that describes and summarizes features of the identified AI techniques and data sets used for their development and validation.

Methods

A scoping review was conducted following the guidelines of PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews). We searched the most commonly used electronic databases (eg, MEDLINE, EMBASE, and PsycInfo) between April 10 and 12, 2020. These terms were selected based on the target intervention (ie, AI) and the target disease (ie, COVID-19). Two reviewers independently conducted study selection and data extraction. A narrative approach was used to synthesize the extracted data.

Results

We considered 82 studies out of the 435 retrieved studies. The most common use of AI was diagnosing COVID-19 cases based on various indicators. AI was also employed in drug and vaccine discovery or repurposing and for assessing their safety. Further, the included studies used AI for forecasting the epidemic development of COVID-19 and predicting its potential hosts and reservoirs. Researchers used AI for patient outcome–related tasks such as assessing the severity of COVID-19, predicting mortality risk, its associated factors, and the length of hospital stay. AI was used for infodemiology to raise awareness to use water, sanitation, and hygiene. The most prominent AI technique used was convolutional neural network, followed by support vector machine.

Conclusions

The included studies showed that AI has the potential to fight against COVID-19. However, many of the proposed methods are not yet clinically accepted. Thus, the most rewarding research will be on methods promising value beyond COVID-19. More efforts are needed for developing standardized reporting protocols or guidelines for studies on AI.
Psychological Impacts of the COVID-19 Outbreak on Chinese International Students: Examining Prevalence and Associated Factors
Authors: Zhao Yilin
Published: July 2020

Background: As the international community has grappled to bring the corona virus disease 2019 (COVID-19) under control, many social factors have emerged and unbearable pressure has been placed on us all. This study aimed to explore the psychological symptoms and influencing factors of the pandemic on Chinese international students. Method: Post-Traumatic Stress Disorder (PTSD) symptoms and other psychological symptoms were investigated using the PTSD Checklist Civilian Version (PCL-C) and the Depression, Anxiety, Stress Scale-21 (DASS-21). Demographic data and data pertaining to the impact of COVID-19 on Chinese international students was also collected.Result: Chinese international students in their fourth year of university education showed higher depressive symptoms, anxiety symptoms, and stress symptoms than students in other years of their degree programs. Each of these psychological symptoms were higher for Chinese international students in high school than for students in their first and second years of university education. Chinese international students who were abroad were found to be most anxious about the risk of infection, financial stress, and travel restrictions following the COVID-19 outbreak.Conclusion: Our study suggest that the effect of COVID-19 on Chinese international students’ psychological symptoms are significant. Our results are valuable for legislators and healthcare providers, who may need to develop effective psychological interventions for Chinese international students.
ОСОБЕННОСТИ ТЕХНОЛОГИИ ИЗГОТОВЛЕНИЯ ТОНКОПЛЕНОЧНЫХ ПРИПОЙНЫХ ПОКРЫТИЙ AU(80)SN(20)
Authors: Фомин А.В. , Иванов В.В. , Филоменко Е.М.
Published: July 2020

В настоящей работе представлены результаты разработки технологии получения тонкопленочных припойных покрытий Au(80)Sn(20) при помощи электронно-лучевого нанесения чередующихся слоев олова и золота. На основании исследований фазообразованиия в изготавливаемых покрытиях разработана схема напыления, позволяющая получить припой, свойства которого удовлетворяют требованиям процесса пайки лазерных диодов к теплоотводящему основанию.
ОСАЖДЕНИЕ СВЕРХТОНКИХ ПЛЕНОК В ВАКУУМЕ ДЛЯ ИЗДЕЛИЙ НАНОЭЛЕКТРОНИКИ
Authors: Панфилов Ю.В. , Родионов И.А. , Рыжиков И.А. , Бабурин А.С. , Москалев Д.О. , Лотков Е.С.
Published: July 2020

Представлены результаты исследований процесса осаждения пленок толщиной менее 100 нм методом электронно-лучевого испарения на специальном вакуумном технологическом оборудовании. Приведены результаты расчета величины энергомассопереноса для получения пленок ITO, Ag и Al с заданной структурой, однородностью состава и шероховатостью
МОДИФИКАЦИЯ И СИНТЕЗ АТОМОВ ВОДОРОДА МЕХАНИЧЕСКИМ ВЗАИМОДЕЙСТВИЕМ
Authors: Деулин Е.А. , Иконникова Е.И. , Коновалов П.И. , Емельяненко Р.О.
Published: July 2020

Авторы рассмотрели физические основы процессов генерации рентгеновских лучей и изотопов водорода при сухом трении. Результаты экспериментов показывают, что тритий также является рентгеновским излучением, возникающим в результате процесса трения.
ПОЛУЧЕНИЕ ПЬЕЗОЭЛЕКТРИЧЕСКИХ ПЛЕНОК ALN РЕАКТИВНЫМ ВЧ-МАГНЕТРОННЫМ РАСПЫЛЕНИЕМ
Authors: Белянин А.Ф. , Багдасарян А.С. , Налимов С.А.
Published: July 2020

Представлены условия получения текстурированных пленок AlN на подложках различных материалов методом реактивного ВЧ-магнетронного распыления. Электронной микроскопией, рентгеновской дифрактометрией, энергетической дисперионной спектроскопией и спектроскопией комбинационного рассеяния света показано влияние условий получения на строение пленок. Представлены результаты использования пленок AlN в качестве пьезоэлектрического слоя устройств на поверхностных акустических волнах. Показана возможность контроля пьезоэлектрической эффективности пленок AlN по спектрам комбинационного рассеяния света.
FINITE ELEMENT MODELING OF TEMPERATURE FIELDS ON THE CUTTING EDGE IN THE DRY HIGH-SPEED TURNING OF AISI 1045 STEEL
Authors: Pérez Roberto , Hernández Luis , Quesada Ana , Pino Julio , Zayas Enrique
Published: July 2020

High-speed turning is an advanced and emerging machining technique that, in contrast to the conventional machining, allows the manufacture of the workpiece with high accuracy, efficiency and quality, with lower production costs and with a considerable reduction in the machining times. The cutting tools used for the conventional machining cannot be employed for high-speed machining due to a high temperature induced in machining and a lower tool life. Therefore, it is necessary to study the influence of high cutting speeds on the temperature distribution in different typologies of cutting tools, with the aim of evaluating their behavior. In this paper, a finite element method modeling approach with arbitrary Lagrangian-Eulerian fully coupled thermal-stress analysis is employed. The research presents the results of different cutting tools (two coated carbide tools and uncoated cermet) effects on average surface temperature fields on the cutting edge in the dry high-speed turning of AISI 1045 steel. The numerical experiments were designed based on different cutting tools like input parameters and different temperature field zones like dependent variables in the dry high-speed turning of AISI 1045 steel. The results indicate that the dry high-speed turning of AISI 1045 steel does not influence significantly the temperature field zones when P10, P15 or P25 inserts are used. Therefore, the use of a dry high-speed turning method, which reduces the amount of lubricant and increases productivity, may represent an alternative to turning to the extent here described.
Oncopedia, software educativo para el aprendizaje de la oncología pediátrica en la carrera de Medicina
Authors: Hernández-García Frank , Robaina-Castillo José Ignacio , Pérez Calleja Norma Ciríaca , González Díaz Elena Del Carmen , Angulo Peraza Blanca Margarita , Hidalgo Ávila Milena , Lazo Herrera Luis Alberto
Published: July 2020

Introducción: Las tecnologías de la informática y las comunicaciones han alcanzado un papel fundamental dentro del proceso de enseñanza-aprendizaje. La enseñanza de la oncología pediátrica en Cuba atraviesa por dificultades que pudieran ser solucionadas a partir del uso eficiente de estas tecnologías. Objetivo: elaborar y validar un producto informático de tipo software educativo sobre oncología pediátrica como apoyo educativo para el aprendizaje de esta temática por estudiantes de medicina. Método: Se realizó una investigación de tipo innovación tecnológica en el periodo de octubre del 2016 a octubre del 2017 en la Facultad de Ciencias Médicas “Dr. José Assef Yara” de Ciego de Ávila. Se delimitaron tres etapas de trabajo, de búsqueda de información, de diseño y confección y comprobación. El programa utilizado como soporte fue Mediator 9.0. Se trabajó con 20 expertos que emitieron sus valoraciones sobre el producto, 21 usuarios definidos por 15 estudiantes del cuarto año de la carrera de Medicina, y seis profesores de Pediatría. Resultados: Se elaboró un producto informático de tipo software educativo, que aborda temas de oncopediatría. Tras su elaboración fue evaluada por expertos como un material funcional con características que le permiten ser aplicado a la docencia médica. Los usuarios afirmaron su satisfacción tras el trabajo con el software. Conclusiones: Oncopedia es un producto atractivo, factible, y fácil de navegar, que hace de su información un texto comprensible, claro, inteligible y bien secuenciado e interrelacionado, capaz de ser utilizado como medio de enseñanza en las universidades médicas del país.
Estrés académico en estudiantes de odontología: asociación con apoyo social, pensamiento positivo y bienestar psicológico
Authors: Luna David , García-Reyes Sandra , Soria-González Erika Araceli , Avila-Rojas Milton , Ramírez-Molina Víctor , García-Hernández Biceida , Meneses-González Fernando
Published: July 2020

Introducción: Estudiantes de odontología presentan altos niveles de estrés académico. El estudio de su relación con variables salutogénicas como el apoyo social, pensamiento positivo y bienestar psicológico podría ser de utilidad para su intervención, potenciar la función benéfica del estrés y evitar sus efectos adversos.Objetivo: Determinar el nivel de estrés académico y sus fuentes en estudiantes de odontología e identificar su asociación con el apoyo social, pensamiento positivo y bienestar psicológico. Establecer si el apoyo social, pensamiento positivo y bienestar psicológico son predictores del estrés académico en esta población.Método: Estudiantes de odontología completaron una batería con una ficha de identificación y los instrumentos Cuestionario de Estrés Académico en la Universidad (CEAU), Escala reducida de Apoyo Social Percibido, Familiar y de Amigos (AFA-R), Escala de Positividad (EP) y la Escala de Bienestar Psicológico para Adultos (BIEPS-A).Resultados: Participaron 146 estudiantes, 104 mujeres y 42 hombres. El nivel de estrés académico, el apoyo social y el pensamiento positivo fue moderado; mientras que el nivel del bienestar psicológico fue alto. Comparadas con hombres, las mujeres mostraron mayor estrés académico (p < 0.01) y menor bienestar psicológico (p < 0.05). El estrés académico correlacionó negativamente con el bienestar psicológico (r = –0.41) y el apoyo social (r = –0.29), pero solo en mujeres. Una regresión lineal múltiple indicó que el bienestar psicológico (ß = –0.27) y el sexo femenino (ß = –0.26) fueron predictores del nivel de estrés académico (p = 0.01). Las situaciones que generaron mayor estrés fueron el desempeño académico y la perspectiva a futuro respecto a su profesión.Conclusiones: Identificar variables salutogénicas predictores del estrés académico, favorece el diseño de estrategias de intervención y el desarrollo positivo de estudiantes de odontología.
Enfermedad por coronavirus: La importancia de enseñar zoonosis bajo el enfoque de “Una Sola Salud”
Authors: Cortés Manuel E.
Published: July 2020

COVID-19 se ha convertido en una nueva pandemia del siglo XXI. Esta carta destaca la importancia de enseñar zoonosis a estudiantes de salud, bajo el enfoque de “Una Sola Salud” como forma de prepararse para enfrentar este tipo de amenazas.
KOMPOSISI PROKSIMAT DAN INDEKS GLIKEMIK NIRA AREN
Authors: Solang Margaretha , Ningsih N. Ismail Yurnia , D. Uno Wirnangsih
Published: July 2020

Penelitian ini bertujuan untuk mengevaluasi komposisi proksimat dan nilai indeks glikemik nira aren. Analisis kadar air menggunakan metode oven, protein menggunakan metode semimikro kjeldhal, kadar abu menggunakan metode thermografimetri, dan lemak menggunakan metode ekstruksi langsung dengan alat soxhlet, karbohidrat menggunakan metode by difference, dan gula mengunakan metode Luff schoorl . Analisis indeks glikemik menggunakan perhitungan luas area dibawah kurva menggunakan metode finger-prick capillary blood. Pengukuran kadar glukosa darah pada 10 orang responden yang diberi glukosa murni dan nira aren. Hasil penelitian menunjukkan nira aren mengandung 91,1% air, 0,28% kadar abu, 0,41% protein, 0% lemak, 8,21% karbohidrat dan 0,67% jumlah gula. Rata-rata glukosa darah responden setelah mengkonsumsi glukosa murni dan nira aren pada menit ke-0, 30, 60, 90, 120 yaitu sebagai berikut 93,2 mg/dL, 155,4 mg/dL, 124,2 mg/dL, 93,8 mg/dL, 79,1 mg/dL, dan 81,8 mg/dL, 118,6 mg/dL, 92,6  mg/dL, 74,1 mg/dL, dan 63,7 mg/dL. Nilai indeks glikemik nira aren adalah 35,56 berada pada kategori rendah, sehingga nira aren merupakan minuman alternatif untuk menjaga kadar gula darah.
MEMÓRIA DA IMAGINAÇÃO - REFLEXOS DA PQ 2019
Authors: Fantová Marketa , Muniz Rosane
Published: July 2020

O rosto da Quadrienal de Praga (PQ) tem mudado lentamente de um estilo de apresentação tradicional, com competições nacionais expostas em uma galeria, para um evento experimental imersivo, um festival. Mas a questão-chave e a principal missão da PQ ainda é a mesma: encontrar maneiras interessantes de apresentar e exibir performance design / cenografia. Como curadora da PQ 2019 e também do próximo evento que acontecerá em 2023, apresento neste breve ensaio as mudanças que vêm ocorrendo ao longo dos anos, e não apenas por uma curadoria, mas por uma equipe de curadores que trabalha para discutir a visão artística, em que desenvolvemos colaborativamente um conceito geral para todos os projetos do festival - um exemplo do trabalho em equipe que buscávamos em nossas exposições e performances. Palavras-ChavesPQ 2019. Quadrienal de Praga. Curadoria. Curador.
Los jóvenes portadores del aprendizaje y habilidades digitales
Authors: Godínes Juan Carlos Valdés , Coelho Patricia Margarida Farias
Published: July 2020

El artículo tiene como base un proyecto de investigación diagnóstico realizado por el Grupo de Investigación “Estudios en Cultura Digital, Sus implicaciones en la Educación y Difusión de la Ciencia”en  colaboración com el grupo de investigación "Formación de Profesores y Tecnologías Digitales: medios, modelos de enseñanza y teorías de aprendizaje" de Brasil. El problema de investigación consistió en hacer una aproximación a las denominadas Habilidades Digitales (HaDi) y al Aprendizaje Digital (ApDi), desde una perspectiva del “ser digital”, lo cual implica un planteamiento diferente a la tradicional idea utilitaria de las Tecnologías de la Información y la Comunicación (TIC); para esto se investigó a los jóvenes  universitarios en tanto portadores del objeto de estudio y sus características, ubicándolos principalmente en su entorno sociocultural cotidiano, más allá del ámbito escolar.Al final del trabajo se pretende que los resultados encontrados puedan incorporarse a enfoques y prácticas educativos escolares relacionados con la implementación de las TIC, que propicien una mejor correspondencia entre los entornos socioculturales no escolarizados y la escuela para alcanzar prácticas docentes más significativas.
A escritora Anita Philipovsky
Authors: Oliveira Loraine Lopes de , Martiniak Vera Lucia
Published: July 2020

Este artigo tem como objetivo analisar as condições materiais que favoreceram a projeção de Anita Philipovsky no campo da literatura. A poetisa pontagrossense fez parte do grupo das escritoras pioneiras no Paraná, publicou seus textos de forma notória no período de 1910 a 1930. Estes, defendiam a ampliação das possibilidades de ensino para as mulheres, na medida em que estas, deveriam ter acesso a outros cursos, além da formação para o magistério. Por sua atuação na sociedade em defesa da educação feminina, a poetisa pode ser compreendida como uma exceção entre as mulheres de seu tempo, na medida em que contrariou os padrões esperados de uma mulher da sociedade republicana: não se casou e não teve filhos. A trajetória intelectual da poetisa e a defesa da educação feminina são analisadas a partir da consulta em fontes primárias que permitem identificar fatores que contribuíram para sua projeção na sociedade, como o círculo social que frequentava, as condições materiais favoráveis para custear sua formação e a influência do pai na literatura.
Educação de pessoas surdas
Authors: Dorziat Ana , Nascimento Edleide Silva do , Romário Lucas
Published: July 2020

O presente estudo teve como objetivo analisar os impactos de um processo de formação continuada de educadores/as, com foco na educação de pessoas surdas, nas práticas educativas de uma escola pública de João Pessoa-PB. Os procedimentos adotados foram: a formação de um grupo de estudo com o público-alvo (educadores/as), realizado quinzenalmente, intercalando aulas de Língua Brasileira de Sinais (Libras) e debates sobre a educação de pessoas surdas; e a observação de práticas educativas, que serviram de parâmetro para confrontar os conhecimentos adquiridos nos momentos formativos. Realizamos 18 (dezoito) encontros, dos quais participaram nove educadores/as, entre professores/as titulares e tutores, professora de AEE, instrutor de Libras, intérprete e especialista. Os dados mostraram que, embora as questões relativas à educação de pessoas surdas envolvam aspectos mais amplos, as discussões realizadas nos momentos formativos tiveram alguns impactos na atuação dos/as profissionais que deles participaram, contribuindo para a construção de uma educação mais inclusiva.
Teorizar o conhecimento
Authors: Sanches Silvana Colombelli Parra , Nascimento Adir Casaro
Published: July 2020

Neste artigo se transita pelo conhecimento produzido no campo da educação em suas dimensões epistêmicas, axiológicas, ontológicas e antropológicas, afim de desembocar nos estudos pós-coloniais ou pós-críticos. Trilhou-se pelos caminhos paradigmáticos do racionalismo, empirismo, positivismo, a fenomenologia, o marxismo e, por último, os autores da modernidade/colonialidade em interface com temáticas relacionadas aos projetos, políticas e tensionamentos educacionais hegemônicos e contra-hegemônicos em âmbito local, regional, nacional e internacional. Este panorama possibilitou, não um aprofundamento e sim um percurso fluido e didático pelas perspectivas teóricas que se apresentam a um professor-pesquisador.
Inteligência artificial em processos de extração de conhecimento KDD e KDT
Authors: Da Silva Luis Roberto Albano Bueno
Published: July 2020

Este artigo visa apresentar, os processos relativos à extração de conhecimento em banco de dados e textos, bem como a técnica de sua aplicação que utiliza inteligência artificial e redes neurais. Busca também, apresentar os possíveis impactos dos paradigmas da inteligência artificial fraca e forte nos processos de extração de conhecimento e promover reflexões à cerca dos mesmos e do impacto científico e social de pesquisas de transição de um modelo para o outro. Além disso, busca contextualizar a tecnologia dentro de um campo permeado em senso comum e visão falaciosa, oriunda do entretenimento e desconhecimento. Para tal, uma revisão de literatura foi desenvolvida sobre extração de conhecimento, para posterior apresentação de reflexões e considerações sobre modelos e visão da tecnologia dentro dos âmbitos das humanidades digitais. Percebeu-se após revisão e análise que as tecnologias de inteligência artificial forte precisam ser protagonizadas para uma melhor utilização das ferramentas de extração de conhecimento, bem como a educação sobre inteligência artificial deve ser promovida entre pesquisadores a fim de mitigar problemas atualmente percebidos.
Jornalismo
Authors: Bertolini Jeferson
Published: July 2020

Este artigo apresenta pesquisa sobre a relação entre jornalismo e biopoder (técnica de poder que busca produzir corpos economicamente ativos). O objetivo é apurar se o conteúdo veiculado por programas jornalísticos sobre saúde é compatível com o biopoder e se isso torna o jornalismo um operador do biopoder. O trabalho usa análise de conteúdo. Adota o programa Bem Estar, da Rede Globo, como objeto de estudo. A relação entre biopoder e jornalismo deve ser estudada porque, de um lado, há uma técnica de poder que busca reger a vida dos indivíduos, tornando-os mais aptos ao mundo capitalista, e, de outro, há um campo midiático que fala às massas.
O umbral inferior da semiótica
Authors: Morales Campos Arturo
Published: July 2020

Abordar o fenómeno semiósico da iconicidade requer não apenas de suportes teóricos de ordem semiótico. Nas últimas seis décadas, tem surgido diálogos altamente construtivos entre as humanidades e as ciencias cognitivas. Isso tem permitido entender ao ser humano desde uma perspectiva mais ampla: como uma entidade biológica e a sua vez cultural.

A presente pesquisa analisa algumas propostas de Umberto Eco, relativas à iconicidade, que verificaremos através de determinados aportes provenientes das ciencias cognitivas. A partir de nossos resultados, proponemos uma ferramenta conceptual, o signo icônico germinal, com a qual, pensamos que a semiótica poderia contribuir à referida aproximação inter ou transdisciplinar.
Not without a head
Authors: Figueiredo Carolina
Published: July 2020

By taking the streets in various demonstrations since 2013, the Brazilian people has answered the call of different internet based social movements. However, there was a denial, both on the part of the individuals, as well as on the part of the movements that there were leaderships behind the organization of the demonstrations, more specifically of the pro-impeachment demonstrations, creating what we call the myth of absence of leadership. This paper aims to deconstruct this myth and to point some of the leaderships behind the pro-impeachment demonstrations that occurred in 2016 in Brazil.
A desconstrução do western em os deuses e os mortos
Authors: Parente Francisco Etruri , Tenório Leda
Published: July 2020

No presente artigo surpreende-se um insuspeito e tanto mais interessante diálogo entre o gênero faroeste e uma obra de referência do Cinema Novo Brasileiro, Os deuses e os mortos de Ruy Guerra. Considerando as particulares relações deste movimento com a questão social brasileira, busca mostrar como o realizador subverte não apenas as regras do gênero, mas a figura do herói, num período já marcado pelas famosas intervenções desconstrutivas de Akira Kurosawa e Sergio Leone, aqui também considerados.
Flora vascular y vivienda de interés social en Villavicencio: conflictos con la conservación de la biodiversidad
Authors: Cruz Fernandez Johanna , Castro Arguello Giovanny Stiven , Ortiz Moreno Martha Lucia
Published: July 2020

Colombia presenta alrededor de 24.530 plantas vasculares. Sin embargo, esta riqueza florística está disminuyendo o presentando algún grado de amenaza, debido a que su hábitat se ha reducido por el desarrollo de actividades realizadas por el hombre como es la urbanización, minería y otras. Esta misma tendencia se observa en Villavicencio. Por ello, la presente investigación tiene como objetivo analizar la diversidad florística remanente en las rondas hídricas del Caño Zuria y humedal La Madrid ubicadas en el barrio homónimo. Para llevar a cabo la investigación, se realizaron muestreos oportunistas donde se colecto material vegetal en estado reproductivo y se identificaron a especie. Como resultados se encontró que la flora asociada al humedal La Madrid posee 19 especies de plantas vasculares agrupadas en 13 familias, siendo Poaceae la mejor representada. De las especies registradas hay dos que están en la categoría de amenaza preocupación menor (LC), las cuales son Andropogon bicornis y Solanum jamaicense. En la flora asociada a la ronda hídrica del caño Zuria se encontraron 21 especies de plantas vasculares agrupadas en 11 familias, de estas la dominante fue Melastomaceae con seis especies, seguida por Araceae con tres especies. De las especies registradas, Psychotria poeppigiana se encuentra en la categoría de amenaza preocupación menor (LC). Los análisis realizados muestran que el desarrollo urbano no sostenible amenaza la biodiversidad de la flora y la oferta de servicios ecosistémicos asociados a las rondas hídricas del caño Zuria y humedal La Madrid en el municipio de Villavicencio.
Tratabilidad de los lixiviados del relleno sanitario los corazones de la ciudad de Valledupar mediante el uso de carbón activado
Authors: Trujillo Romero Omar Enrique , Quintero Tovar Andres Luciano , Vega Suarez Julio Cesar
Published: July 2020

La investigación realizada evaluó la tratabilidad en términos de remoción de materia orgánica (DQO) presente en  los lixiviados del relleno sanitario Los  Corazones de la ciudad Valledupar, a través del proceso de adsorción con carbón activado, desarrollado bajo dos modelos  de flujo hidráulico (reactores continuos y discontinuos) analizando variables como dosis, tiempo de contacto y PH, con la finalidad de comparar y obtener el mayor rendimiento en la  remoción de carga orgánica de los lixiviados en estudio.

Para reactores discontinuos con lixiviado crudo se obtuvieron resultados de un 67% de remoción de materia orgánica, modificando el PH a 3 se obtuvieron resultados de un 80 % de remoción de materia orgánica, obteniendo a su vez las mejores condiciones de remoción de DQO en el modelo de flujo discontinuo empleando dosis de 100g/l con tiempos de contacto de 90 minutos.

El reactor continuo se utilizó con caudal de 6 ml/min, tiempo de retención hidráulico de 90 min, dosis utilizada de 640g de carbón activado, donde se ensayó con lixiviado crudo obteniéndose remociones de carga orgánica del 83%, ajustando el pH a 3  se obtuvo remociones del 97%.
Pronóstico del caudal del río Cravo sur, sector del Morro – Puente la Cabuya, departamento de Casanare, Colombia
Authors: Higuera Infante Linson Javier , Rojas Vergara William
Published: July 2020

Colombia presenta una gran red hidrográfica en la región de los llanos orientales donde el Instituto de Hidrología, Meteorología y Estudios Ambientales IDEAM cuenta con estaciones hidrometeorológicas capaces de llevar registros de lluvia en el tiempo, siendo estas necesarias para la realización de estudios que permitan efectuar seguimiento a esta red y así fundamentar la toma de decisiones en sectores que se ven afectados por las variaciones climáticas que se presentan.De acuerdo a la situación mencionada, se pretende pronosticar el caudal circundante al Municipio de Yopal y obtener elementos que sirvan de base para prever y minimizar riesgos especialmente al sector del agro colombiano el cual, es característico de esta región.Se plantea un estudio de caso del caudal en la cuenca media del Río Cravo Sur en una serie temporal de periodicidad mensual desde el año 1975 hasta el 2014, luego se realiza un análisis exploratorio de datos el cual, permite visualizar los estadísticos descriptivos que sirven para evaluar el comportamiento general de la serie, posteriormente se analiza la misma con el fin de determinar el modelo más apropiado para el pronóstico.Como resultado, se determinó que, a lo largo del tiempo, los caudales tienden levemente a aumentar, pero sin generar riesgos superiores a los que en la actualidad está expuesta la región especialmente en épocas de constantes lluvias; esta estimación se ajusta a las características propias de la estación y depende única y exclusivamente de su historia.