bluuebunny/crossref_metadata_2025 huggingface dataset:
Microwave-Assisted Synthesis of Modified Glycidyl Methacrylate–Ethyl Methacrylate Oligomers, Their Physico-Chemical and Biological Characteristics
Authors: Chyzy Adam , Pawelski Damian , Vivcharenko Vladyslav , Przekora Agata , Bratychak Michael , Astakhova Olena , Breczko Joanna , Drozdzal Pawel , Plonska-Brzezinska Marta E.
Published: January 2022

In this study, well-known oligomers containing ethyl methacrylate (EMA) and glycidyl methacrylate (GMA) components for the synthesis of the oligomeric network [P(EMA)-co-(GMA)] were used. In order to change the hydrophobic character of the [P(EMA)-co-(GMA)] to a more hydrophilic one, the oligomeric chain was functionalized with ethanolamine, xylitol (Xyl), and L-ornithine. The oligomeric materials were characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy, scanning electron microscopy, and differential thermogravimetric analysis. In the final stage, thanks to the large amount of -OH groups, it was possible to obtain a three-dimensional hydrogel (HG) network. The HGs were used as a matrix for the immobilization of methylene blue, which was chosen as a model compound of active substances, the release of which from the matrix was examined using spectrophotometric detection. The cytotoxic test was performed using fluid extracts of the HGs and human skin fibroblasts. The cell culture experiment showed that only [P(EMA)-co-(GMA)] and [P(EMA)-co-(GMA)]-Xyl have the potential to be used in biomedical applications. The studies revealed that the obtained HGs were porous and non-cytotoxic, which gives them the opportunity to possess great potential for use as an oligomeric network for drug reservoirs in in vitro application.
4-Deoxy-l-erythro-5-hexoseulose Uronate (DEH) and DEH Reductase: Key Molecule and Enzyme for the Metabolism and Utilization of Alginate
Authors: Kawai Shigeyuki , Hashimoto Wataru
Published: January 2022

4-Deoxy-l-erythro-5-hexoseulose uronate (DEH), DEH reductase, and alginate lyase have key roles in the metabolism of alginate, a promising carbon source in brown macroalgae for biorefinery. In contrast to the widely reviewed alginate lyase, DEH and DEH reductase have not been previously reviewed. Here, we summarize the current understanding of DEH and DEH reductase, with emphasis on (i) the non-enzymatic and enzymatic formation and structure of DEH and its reactivity to specific amino groups, (ii) the molecular identification, classification, function, and structure, as well as the structural determinants for coenzyme specificity of DEH reductase, and (iii) the significance of DEH for biorefinery. Improved understanding of this and related fields should lead to the practical utilization of alginate for biorefinery.
Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation
Authors: Cianciulli Antonia , Calvello Rosa , Ruggiero Melania , Panaro Maria Antonietta
Published: January 2022

Inflammaging is a term used to describe the tight relationship between low-grade chronic inflammation and aging that occurs during physiological aging in the absence of evident infection. This condition has been linked to a broad spectrum of age-related disorders in various organs including the brain. Inflammaging represents a highly significant risk factor for the development and progression of age-related conditions, including neurodegenerative diseases which are characterized by the progressive dysfunction and degeneration of neurons in the brain and peripheral nervous system. Curcumin is a widely studied polyphenol isolated from Curcuma longa with a variety of pharmacologic properties. It is well-known for its healing properties and has been extensively used in Asian medicine to treat a variety of illness conditions. The number of studies that suggest beneficial effects of curcumin on brain pathologies and age-related diseases is increasing. Curcumin is able to inhibit the formation of reactive-oxygen species and other pro-inflammatory mediators that are believed to play a pivotal role in many age-related diseases. Curcumin has been recently proposed as a potential useful remedy against neurodegenerative disorders and brain ageing. In light of this, our current review aims to discuss the potential positive effects of Curcumin on the possibility to control inflammaging emphasizing the possible modulation of inflammaging processes in neurodegenerative diseases.
Solvent-Free Synthesis, In Vitro and In Silico Studies of Novel Potential 1,3,4-Thiadiazole-Based Molecules against Microbial Pathogens
Authors: Shehadi Ihsan A. , Abdelrahman Mohamad T. , Abdelraof Mohamed , Rashdan Huda R. M.
Published: January 2022

A new series of 1,3,4-thiadiazoles was synthesized by the reaction of methyl 2-(4-hydroxy-3-methoxybenzylidene) hydrazine-1-carbodithioate (2) with selected derivatives of hydrazonoyl halide by grinding method at room temperature. The chemical structures of the newly synthesized derivatives were resolved from correct spectral and microanalytical data. Moreover, all synthesized compounds were screened for their antimicrobial activities using Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Bacillus subtilis, Staphylococcus aureus, and Candida albicans. However, compounds 3 and 5 showed significant antimicrobial activity against all tested microorganisms. The other prepared compounds exhibited either only antimicrobial activity against Gram-positive bacteria like compounds 4 and 6, or only antifungal activity like compound 7. A molecular docking study of the compounds was performed against two important microbial enzymes: tyrosyl-tRNA synthetase (TyrRS) and N-myristoyl transferase (Nmt). The tested compounds showed variety in binding poses and interactions. However, compound 3 showed the best interactions in terms of number of hydrogen bonds, and the lowest affinity binding energy (−8.4 and −9.1 kcal/mol, respectively). From the in vitro and in silico studies, compound 3 is a good candidate for the next steps of the drug development process as an antimicrobial drug.
Supercritical CO2 Extraction of Narcissus poeticus L. Flowers for the Isolation of Volatile Fragrance Compounds
Authors: Baranauskienė Renata , Venskutonis Petras Rimantas
Published: January 2022

The flowers of Narcissus poeticus are used for the isolation of valuable fragrance substances. So far, as the majority of these substances consist of volatile and sensitive to heat compounds, there is a need of developing effective methods for their recovery. In this study, freeze-dried N. poeticus inflorescences were extracted with pure supercritical CO2 (SFE-CO2) and its mixture with 5% co-solvent ethanol (EtOH) at 40 °C. Extract yields varied from 1.63% (12 MPa) to 3.12% (48 MPa, 5% EtOH). In total, 116 volatile compounds were identified by GC-TOF/MS in the extracts, which were divided into 20 different groups. Benzyl benzoate (9.44–10.22%), benzyl linoleate (1.72–2.17%) and benzyl alcohol (0.18–1.00%) were the major volatiles among aromatic compounds. The amount of the recovered benzyl benzoate in N. poeticus SFE-CO2 extracts varied from 58.98 ± 2.61 (24 MPa) to 91.52 ± 1.36 (48 MPa) mg/kg plant dry weight (pdw). α-Terpineol dominated among oxygenated monoterpenes (1.08–3.42%); its yield was from 9.25 ± 0.63 (12 MPa) to 29.88 ± 1.25 (48 MPa/EtOH) mg/kg pdw. Limonene was the major monoterpene hydrocarbon; (3E)-hexenol and heneicosanol dominated among alcohols and phenols; dihydroactinidiolide and 4,8,12,16-tetramethyl heptadecan-4-olide were the most abundant lactones; heptanal, nonanal, (2E,4E)-decadienal and octadecanal were the most abundant aldehydes. The most important prenol lipids were triterpenoid squalene, from 0.86 ± 0.10 (24 MPa) to 7.73 ± 0.18 (48 MPa/EtOH) mg/kg pdw and D-α-tocopherol, from 1.20 ± 0.04 (12 MPa) to 15.39 ± 0.31 (48 MPa/EtOH) mg/kg pdw. Aliphatic hydrocarbons (waxes) constituted the main part (41.47 to 54.93%) in the extracts; while in case of a 5% EtOH the percentage of alkanes was the lowest. The fraction of waxes may be removed for the separation of higher value fragrance materials. In general, the results obtained are promising for a wider application of SFE-CO2 for the recovery of fragrance substances from N. poeticus flowers.
Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives
Authors: Arshad Nasima , Mir Muhammad Ismail , Perveen Fouzia , Javed Aneela , Javaid Memona , Saeed Aamer , Channar Pervaiz Ali , Farooqi Shahid Iqbal , Alkahtani Saad , Anwar Jamshed
Published: January 2022

Imidazolidine and thiazolidine-based isatin derivatives (IST-01–04) were synthesized, characterized, and tested for their interactions with ds-DNA. Theoretical and experimental findings showed good compatibility and indicated compound–DNA binding by mixed mode of interactions. The evaluated binding parameters, i.e., binding constant (Kb), free energy change (ΔG), and binding site sizes (n), inferred comparatively greater and more spontaneous binding interactions of IST-02 and then IST-04 with the DNA, among all compounds tested under physiological pH and temperature (7.4, 37 °C). The cytotoxic activity of all compounds was assessed against HeLa (cervical carcinoma), MCF-7 (breast carcinoma), and HuH-7 (liver carcinoma), as well as normal HEK-293 (human embryonic kidney) cell lines. Among all compounds, IST-02 and 04 were found to be cytotoxic against HuH-7 cell lines with percentage cell toxicity of 75% and 66%, respectively, at 500 ng/µL dosage. Moreover, HEK-293 cells exhibit tolerance to the increasing drug concentration, suggesting these two compounds are less cytotoxic against normal cell lines compared to cancer cell lines. Hence, both DNA binding and cytotoxicity studies proved imidazolidine (IST-02) and thiazolidine (IST-04)-based isatin derivatives as potent anticancer drug candidates among which imidazolidine (IST-02) is comparatively the more promising.
The Role of Strontium in CeNiO3 Nano-Crystalline Perovskites for Greenhouse Gas Mitigation to Produce Syngas
Authors: Ahmad Naushad , Wahab Rizwan , Manoharadas Salim , Alrayes Basel F. , Alam Manawwer , Alharthi Fahad A.
Published: January 2022

The transition metal-based catalysts for the elimination of greenhouse gases via methane reforming using carbon dioxide are directly or indirectly associated with their distinguishing characteristics such as well-dispersed metal nanoparticles, a higher number of reducible species, suitable metal–support interaction, and high specific surface area. This work presents the insight into catalytic performance as well as catalyst stability of CexSr1−xNiO3 (x = 0.6–1) nanocrystalline perovskites for the production of hydrogen via methane reforming using carbon dioxide. Strontium incorporation enhances specific surface area, the number of reducible species, and nickel dispersion. The catalytic performance results show that CeNiO3 demonstrated higher initial CH4 (54.3%) and CO2 (64.8%) conversions, which dropped down to 13.1 and 19.2% (CH4 conversions) and 26.3 and 32.5% (CO2 conversions) for Ce0.8Sr0.2NiO3 and Ce0.6Sr0.4NiO3, respectively. This drop in catalytic conversions post strontium addition is concomitant with strontium carbonate covering nickel active sites. Moreover, from the durability results, it is obvious that CeNiO3 exhibited deactivation, whereas no deactivation was observed for Ce0.8Sr0.2NiO3 and Ce0.6Sr0.4NiO3. Carbon deposition during the reaction is mainly responsible for catalyst deactivation, and this is further established by characterizing spent catalysts.
Prospects of Curcumin Nanoformulations in Cancer Management
Authors: Amekyeh Hilda , Alkhader Enas , Sabra Rayan , Billa Nashiru
Published: January 2022

There is increasing interest in the use of natural compounds with beneficial pharmacological effects for managing diseases. Curcumin (CUR) is a phytochemical that is reportedly effective against some cancers through its ability to regulate signaling pathways and protein expression in cancer development and progression. Unfortunately, its use is limited due to its hydrophobicity, low bioavailability, chemical instability, photodegradation, and fast metabolism. Nanoparticles (NPs) are drug delivery systems that can increase the bioavailability of hydrophobic drugs and improve drug targeting to cancer cells via different mechanisms and formulation techniques. In this review, we have discussed various CUR-NPs that have been evaluated for their potential use in treating cancers. Formulations reviewed include lipid, gold, zinc oxide, magnetic, polymeric, and silica NPs, as well as micelles, dendrimers, nanogels, cyclodextrin complexes, and liposomes, with an emphasis on their formulation and characteristics. CUR incorporation into the NPs enhanced its pharmaceutical and therapeutic significance with respect to solubility, absorption, bioavailability, stability, plasma half-life, targeted delivery, and anticancer effect. Our review shows that several CUR-NPs have promising anticancer activity; however, clinical reports on them are limited. We believe that clinical trials must be conducted on CUR-NPs to ensure their effective translation into clinical applications.
Reflux Extraction Optimization and Antioxidant Activity of Phenolic Compounds from Pleioblastus amarus (Keng) Shell
Authors: Ma Yuan , Meng Ailian , Liu Ping , Chen Yuanyuan , Yuan Anqi , Dai Yemei , Ye Kunyue , Yang Yi , Wang Yiping , Li Zhuoman
Published: January 2022

Phenols were extracted from the Pleioblastus amarus (Keng) shell (PAS) using ethanol. A Plackett–Burman assessment indicated that the factors affecting polyphenol extraction included the ethanol concentration, extraction temperature, liquid to solid ratio, extraction time, and reflux extraction times; the best extraction parameters were the ethanol concentration of 75%, a 20:1 liquid to solid ratio, and an extraction time of 2.1 h. The number of polyphenols was 7.216 mg/g. Furthermore, the phenol composition analysis showed the presence of p-Coumaric acid (196.88 mg /mL) and rutin (312.9 mg /mL), which were used for the in vitro extraction and determination of the antioxidant activity. According to the A, B, C, and D antioxidant activity assays, the ethyl acetate phase was the strongest with low IC50 values of 0.169 ± 0.01 mg/mL, 0.289 ± 0.01 mg/mL, 0.372 ± 0.01 mg/mL, and 1.029 ± 0.03 mg/mL, respectively, confirming high antioxidant activity. For the n-butanol and petroleum ether phases, antioxidant activity was lower. This study showed that the polyphenol extract from Pleioblastus amarus (Keng) shell displayed excellent antioxidant activity, enhancing its practical application.
Alkaline Stable Anion Exchange Membranes Based on Cross-Linked Poly(arylene ether sulfone) Bearing Dual Quaternary Piperidines for Enhanced Anion Conductivity at Low Water Uptake
Authors: Sharma Prem P. , Jeon Yeeun , Kim Dukjoon
Published: January 2022

Alkaline stable anion exchange membranes based on the cross-linked poly(arylene ether sulfone) grafted with dual quaternary piperidine (XPAES-DP) units were synthesized. The chemical structure of the synthesized PAES-DP was validated using 1H-NMR and FT-IR spectroscopy. The physicochemical, thermal, and mechanical properties of XPAES-DP membranes were compared with those of two linear PAES based membranes grafted with single piperidine (PAES-P) unit and conventional trimethyl amine (PAES-TM). XPAES-DP membrane showed the ionic conductivity of 0.021 S cm−1 at 40 °C which was much higher than that of PAES-P and PAES-TM because of the possession of more quaternary ammonium groups in the cross-linked structure. This cross-linked structure of the XPAES-DP membrane resulted in a higher tensile strength of 18.11 MPa than that of PAES-P, 17.09 MPa. In addition, as the XPAES-DP membrane shows consistency in the ionic conductivity even after 96 h in 3 M KOH solution with a minor change, its chemical stability was assured for the application of anion exchange membrane fuel cell. The single-cell assembled with XPAES-DP membrane displayed a power density of 109 mWcm−2 at 80 °C under 100% relative humidity.
Optimized Protocols for the Propagation and Quantification of Infectious Murine Hepatitis Virus (MHV-A59) Using NCTC Clone 1469 and 929 Cells
Authors: Shuipys Tautvydas , Montazeri Naim
Published: January 2022

Murine hepatitis virus (MHV) is a non-human pathogen betacoronavirus that is evolutionarily and structurally related to the human pathogenic viruses SARS-CoV, MERS-CoV, and SARS-CoV-2. However, unlike the human SARS and MERS viruses, MHV requires a biosafety level 2 laboratory for propagating and safe handling, making it a potentially suitable surrogate virus. Despite this utility, few papers discussed the propagation and quantification of MHV using cell lines readily available in biorepositories making their implementations not easily reproducible. This article provides protocols for propagating and quantifying MHV-A59 using the recommended NCTC clone 1469 and clone 929 cell lines from American Type Culture Collection (ATCC). More specifically, the methods detail reviving cells, routine cell passaging, preparing freeze stocks, infection of NCTC clone 1469 with MHV and subsequent harvesting, and plaque assay quantification of MHV using NCTC clone 929 cells. Using these protocols, a BSL-2 laboratory equipped for cell culture work would generate at least 6.0 log plaque-forming units (PFU) per mL of MHV lysate and provide an optimized overlay assay using either methylcellulose or agarose as overlays for the titration of infectious virus particles. The protocols described here are intended to be utilized for persistence and inactivation studies of coronaviruses.
Implementasi Akuntansi Sosial Pengrajin Minyak Kelapa di Desa Kedungkamal Kabupaten Purworejo
Authors: Astuti Diah Ayu Sekar
Published: January 2022

Penelitian ini bertujuan untuk mengetahui penerapan akuntansi sosial yang dilakukan pengrajin minyak kelapa. Penelitian ini di lakukan karena adanya keunikan proses bisnis pengrajin minyak kelapa yaitu adanya simbiosis mutualisme dengan masyarakat sekitar. Data yang diperoleh dianalisis menggunakan metode kualitatif deskriptif. Tempat penelitian di lakukan di Kelurahan Kedungkamal, Kecamatan Grabag, Kabupaten Purworejo. Sumber data yang di gunakan dalam penelitian ini adalah data primer. Pengumpulan data dengan partisipasi langsung wawancara pada pengrajin minyak kelapa maupun tokoh masyarakat setempat. Hasil penelitian menunjukkan pengrajin minyak kelapa membawa keberuntungan bagi masyarakat sekitar, yaitu hasil tanam pohon kelapa dibeli pengrajin kelapa dan penduduk desa mendapatkan pekerjaan. Dampak lingkungan diterima masyarakat berdasarkan nilai-nilai budaya Jawa yaitu prinsip kekeluargaan dan “tepo sliro”. Implikasi penelitian ditujukan kepada aktor quintuple helix untuk menjaga keberlanjutan akuntansi hijau.
Akuntansi Sektor Publik Dalam Potret Khazanah Budaya Melayu
Authors: Briando Bobby
Published: January 2022

Artikel ini merupakan bentuk kritik atas pengadopsian standar akuntansi sektor publik yang berkiblat IFRS. Pengadopsian secara paripurna oleh dewan standar akuntansi terkait standar akuntansi sektor publik sesungguhnya tidak sesuai dengan semangat dan jatidiri bangsa Indonesia, khususnya budaya Melayu. Tulisan ini bertujuan untuk membentuk kesadaran akan khasanah budaya Melayu yang sangat kental dengan nilai-nilai ketuhanan dan berkearifan lokal. Hasil menunjukkan jika pengadopsian secara paripurna terkait standar akuntansi sektor publik tidak sesuai dengan spirit dan khasanah budaya melayu.
Clinical-ultrasound and clinical-morphological characteristics of adnexal torsion in girls and adolescents
Authors: Tuchkina I.O. , Kiebashvili S.V. , Piontkovska O.V. , Romanova N.V.
Published: January 2022

Clinical-ultrasound and clinical-morphological characteristics of adnexal torsion to the improvement of early diagnosis and development of optimal ways of organ-preserving surgical tactics of treatment have been determined. An analysis was carried out of 71 patients with adnexal torsion (group 1– 30 girls of 2–12 years, group 2 – 41 adolescents of 13–17 years). The main clinical signs of adnexal torsion were nonspecific and similar to the well-known clinic of acute abdomen. Ultrasound examination with color doppler mapping (CDM) allowed to suspect adnexal torsion in 44 (62 %) patients. The main echographic features of adnexal torsion were: ovarian enlargement, non-typical location and a change in the structure of ovary, the presence of a free liquid in the cavity of a small pelvis or in the abdominal cavity, «a symptom of springs» (a twisted vascular leg), a decrease or absence of blood flow in CDM. The torsion of intact uterine appendages is installed in 29 patients (twice as often in group 1). In 42 cases were detected the torsion of the uterine appendages, compromised by the presence of tumors and tumor-like formations (twice as often in group 2). In both groups, 36 (50.7 %) organ-preserving and 35 (49.3 %) radical operations were carried out. According to the results of morphological examination of the removed tissues, the following data were obtained: follicular cysts – 15, paratubal cysts – 8, corpus luteum cysts – 8, teratomas – 5, serous cystadenomas – 2, mucinous cystadenoma – 1, paraovarian cysts – 3. Differential diagnosis of adnexal torsion in girls and adolescents should include a thorough collection of anamnestic data, taking into account the features of the clinical course of the disease, the results of a comprehensive examination with an assessment of ultrasound data from CDM, computer and magnetic resonance imaging, which will contribute to the advanced adequate selection of tactics of urgent gynecological intervention. The method of choice for the treatment of adnexal torsion is a minimally invasive surgical intervention – a laparoscopy with organ-preserving operations.

Keywords: adnexal torsion, girls, ultrasound and morphological characteristics.
Investigation of robust ship course control based on auxiliary loop method
Authors: Imangazieva Aliya
Published: January 2022

A novel robust control law is investigated on the problem of ship stabilization on the trajectory, which allows one to compensate perturbations in the parameters of the mathematical model of ship dynamics in cases of their changes caused by external conditions, namely: sea waves, currents, wind gusts, etc. To implement the proposed control law, only measured adjustable values are required such as the yaw angle and the control action that is the angle of the rudder of the ship. The synthesized ship course control system was investigated in MATLAB. The law of controlling the ship’s course
with unknown parameters and external disturbances in the power supply is proposed. The design of the control law is based on a robust auxiliary loop algorithm and Khalil observers. The simulations illustrate the efficiency of the proposed control law.
Centro arqueológico Inka Pakarita un desarrollo turístico en el departamento de Puno, Perú
Authors: Mamani Grecia , Mamani Hugo
Published: January 2022

The study presents the results obtained from an archaeological survey proposing a tourism development plan in the Huertas sector of the peasant community of Huata Quita, district of Cabanillas, department of Puno, where the Inka Pakarita archaeological center is located, since there is evidence of three Funeral Chullpas with galleries of up to three floors belonging to the Pre-Inca culture of Tiahuanaco, where human bones and numerous seed roots (corn, wheat, quinoa) were found, the objective of the study was to encourage the authorities to be interested in the construction of a tourist center to promote and encourage local and national tourism to attract economic resources and promote community development so that there is a management of tourism and thus promote knowledge of archaeological sites. The methodology is purely descriptive; the archaeological prospecting was applied accentuated in the propositional intention. The results reflected the lack of interest and the little value to the archeology of the governmental authorities.
Magnetoelastic constant of thin films determined by a four-point bending apparatus
Authors: Yoshihara Shintaro , Yanagihara Hideto
Published: January 2022

We have developed a method to variably induce lattice strains and to quantitatively evaluate the induced magnetic anisotropy. Both tensile and compressive strains were introduced into epitaxial films of cobalt ferrite (CFO) grown on a single crystal MgO(001) substrate using a four-point bending apparatus made of a plastic material fabricated by a 3D printer. The change in magnetic anisotropy due to bending strain can be measured quantitatively by using the conventional magneto-torque meter. The strain-induced magnetic anisotropy increased with the tensile strain and decreased with the compressive strain as expected from a phenomenological magnetoelastic theory. The magnetoelastic constant obtained from the changes in bending strains shows quantitatively good agreement with that of the CFO films with a uniaxial epitaxial strain. This signifies that the magnetoelastic constant can be evaluated by measuring only one film sample with strains applied by using the bending apparatus.
Extraction and oxidative desulfurization of bitumen from oil sand using n-pentane and ultrasound
Authors: Wakisaka Yoshitaka , Okawa Hirokazu , Saigo Kumi , Kato Takahiro , Sugawara Katsuyasu
Published: January 2022

Oil sand contains about 15 wt% bitumen which contains approximately 5 wt% sulfur. Bitumen must be extracted from sand and desulfurized before use as a fuel. Currently, bitumen is recovered from sand using hot water (80 °C) and sulfur is removed via hydrodesulfurization (200 °C–450 °C), which consumes large amounts of energy. Therefore, we investigated the separation of bitumen from sand and the oxidative desulfurization of bitumen using ultrasound and n-pentane at 20 °C. We successfully extracted 94 wt% bitumen from sand and removed 66.1% of the sulfur via oxidative desulfurization using 15 wt% H2O2 and 5 mol l−1 NaOH.
Edukasi Pentingnya Vaksinasi dan Protokol Kesehatan 5M dalam Menghadapi COVID-19 pada Jemaat Waai
Authors: Margaretha M. A. Apituley  , Febryanti Sariwating  , Aprilia F. Telussa  , Stephany B. Sopacua  , Helenna M. Tahitu  , Wenly Lekahena  , Mansye Ruhulesin  , Megawatty Wuarlela  , Adventia Liklikwatil  , Jelly V. D. Tahitu
Published: January 2022

Virus Corona atau severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adalah virus yang menyerang sistem pernapasan. Penyakit karena infeksi virus ini disebut COVID-19.  Infeksi virus Corona disebut COVID-19 (Corona Virus Disease 2019) dan pertamakali ditemukan di kota Wuhan, China pada akhir Desember 2019. Virus ini menular dengan sangat cepat dan telah menyebar ke hampir semua Negara termasuk Indonesia, hanya dalam waktu beberapa bulan. Di Indonesia masuk pada awal Maret 2020. Dengan adanya virus corona ini pemerintah mengambil banyak tindakan salah satunya adalah Vaksinasi untuk mencegah atau meminimalisir penularan Covid 19 khususnya di Indonesia, namun yang menjadi masalahnya adalah banyak masayarakat yang masih acuh tahu dengan Vaksinasi ataupun dengan Protokol kesehatan 5M. Untuk membantu upaya pemerintah dalam mengahadapi masalah ini maka, Mahasiswa KKN Universitas Kristen Indonesia Maluku Fakultas Theologi Angkatan 2021 akan melakukan program-program guna mengedukasi masyarakat akan pentingnya Vaksinasi dan Protokol Kesehatan 5 M dalam menghadapi Virus Corona, selain itu Kegiatan KKN ini juga mengangkat masalah sampah yang terjadi di jemaat focus kelompok. Kegiatan dilakukan secara berkelompok dan dibimbing oleh instruktur KKN secara online. Setiap program akan dilakukan baik secara online maupun offline dengan penerapan protokol Kesehatan, program-program tersebut antara lain, sosialisasi vaksinasi dan protokol kesehatan 5M,  Pembagian Masker dan Pembuatan Video Kreatif Vaksinasi dan beberapa kegiata lainnya sebagai pendukung. Semua kegiatan ini diharapkan untuk membantu dan  membangun kesadaran Masyarakat untuk dapat mencegah Virus Corona ataupu menyelesaikan msalah yang ada dalam jemaat Waai. Kegiatan kelompok akan di khususkan pada jemaat Waai Kecamatan Salahutu, Kabupaten Maluku Tengah.
Edukasi Pentingnya Disiplin Protokol Kesehatan di Tengah Pandemic COVID-19 pada Jemaat GPM Eden Kudamati
Authors: Helena Berhitu  , Stensya Parera  , Prily Sopacua  , Yunet Salenussa  , Regina Bembuain  , Johan Robert Saimima
Published: January 2022

Jemaat GPM Eden merupakan jemaat yang dilembagakan dari jemaat Rehoboth pada tanggal 12 februari 2012 yang dilakukan melalui tahap yang panjang. Yang mana tahun 2001 melalui persidangan ke 17 jemaat GPM Rehoboth di gedung gereja Getsemani diputuskan untuk dilakukan pemekaran jemaat, mengingat luasnya wilayah pelayanan dan jumlah anggota jemaat GPM rehobot yang terus bertambah. Dan dalam perjalanan waktu sampai sekarang, jemaat GPM Eden mengalami perkembangan baik dari pertambahan jumlah umat, unit dan sektor secara keseluruhan. Sesuai dengan keadaan yang terjadi pada saat ini juga dapat kita ketahui bahwa bangsa ini sedang dilanda dengan adanya COVID-19 dimana ditambah lagi dengan adanya varian baru yaitu varian delta. Hal ini dirasakan di kota Ambon terlebih khusus juga pada jemaat GPM Eden yang tidak terlepas juga dari dampak penyebaran Virus Corona. Untuk  menghindari  angka  penderita  yang  terus  meningkat,  maka pemerintah memberikan pembatasaan kegiatan yang menimbulkan keramaian, menjaga jarak dan menjaga hygenitas pada masyarakat dalam melakukan kegiatan sehari-hari yang dikenal dengan peraturan protokol kesehatan. Hal yang pertama terlihat adalah pada sisi kebersihan, dan juga memperhatikan protokol kesehatan. Oleh karena itu tujuan kegiatan pengabdian masyarakat ini adalah untuk mengingatkan dan membantu pemahaman masyarakat tentang pelaksanaan protokol kesehatan selama pendemi COVID-19 yaitu dengan melakukan pembagian masker, pembagian tempat sampah, pembuatan spanduk mengenai tata cara pemutusan mata rantai COVID-19 dan pentingnya vaksinasi, adanya juga program saberling, bahkan penyemprotan yang di lakukan dalam Jemaat GPM Eden.
Edukasi Vaksin dan Prokes 5M bagi Remaja-Pemuda Sebagai Gerakan Spiritualitas Pro Hidup Hadapi Pandemi COVID-19 di Jemaat Bethania dan Menara Kasih, Klasis GPM Kota Ambon
Authors: Adam Lakarang  , Lidya Parera  , Bernhard Marantika  , Charles Maloky  , Febry Walaia  , Marco Wedilen  , Iluy Noija  , Carollus de Queljoe  , Eklefina Pattinama
Published: January 2022

Pengabdian kepada masyarakat ini ditujukan kepada pemuda-remaja untuk mengikuti vaksin dan mematuhi protokol kesehatan 5M, serta melakukan gerakkan spiritualitas pro hidup dengan aksi bersih lingkungan, mengajak teman sebaya disiplin menggunakan protokol kesehatan 5M. Berbagai cara digunakan untuk memutuskan mata rantai penyebaran Virus Corona. Cara ini dalam masa Pandemi COVID-19 digunakan untuk mewujudkan gerakan spiritualitas pro hidup kepada pemuda dan remaja, juga dengan cara, memberi penjelasan tentang Vaksin, mematuhi protokol kesehatan 5M dan disiplin melakukan gerakan spiritualitas pro hidup dengan merawat diri dan juga merawat teman/orang lain. Ada pun metode pembinaan dimulai dari rencana, pelaksanaan, membangun kerja sama dengan mitra dan pelaksanaan kegiatan. Model gerakan spiritualitas pro hidup yang digunakan adalah mendampingi dan mendorong pemuda remaja mengambil keputusan untuk vaksin dan tetap mematuhi protokkol kesehatan agar pemuda remaja dapat menggerakkan teman sebaya untuk displin protokol kesehatan 5M dan mengikuti vaksin dalam merawat hidup di masa Pandemik COVID-19. Gerakan spiritualitas pro hidup bagi pemuda dan remaja sangat penting bagi masa depan mereka untuk menumbuhkan iman mereka sebagai karya Allah yang menyelamatkan pemuda dan remaja gereja di masa pandemik.
CLINICOPATHOLOGICAL STUDY OF ORAL LESIONS IN A TERTIARY CARE HOSPITAL
Authors: Ponnada Sravani , Latchupatula Lakshmi , Krishna Srivathsav Tadikonda , Atla Bhagyalakshmi
Published: January 2022

Background: Oral cavity is a common site for various non-neoplastic and neoplastic lesions. Majority of
lesions were neoplastic. Tobacco chewing, smoking and alcohol consumption were the common risk
factors implicated in the etiology of malignant oral lesions. Squamous cell carcinoma was the most common lesion of the oral
cavity.
Aims&Objectives: To study the clinicopathological lesions of the oral cavity with respect to age, gender, location, clinical
presentation, histopathological patterns and various risk factors.
Materials And Methods: A retrospective study of 274 oral cavity lesions conducted for period of 2 years from January 2019 to
December 2020 in the department of pathology, Andhra Medical College, Visakhapatnam, Andhra Pradesh.
Results: In our study, the age range of the patients was from 3 years to 87 years. Majority of cases were seen in age group of 41-
50 years. Males were more commonly affected than females with a male to female ratio of 2.51:1. Majority of oral lesions were
malignant. Squamous cell carcinoma was the most common oral lesion. Tongue was the most common site involved in oral
lesions. Mucocele was the commonest non-neoplastic lesion and squamous papilloma was the most common benign lesion.
Leucoplakia was the most common premalignant lesion and Squamous cell carcinoma was the commonest malignant lesion.
Conclusion: Majority of oral lesions were malignant. Squamous cell carcinoma was the most common oral lesion. Early and
accurate identication of potentially malignant oral lesions is important and essential for prevention of morbidity, mortality
and for proper treatment of cases. Along with clinical examination and laboratory investigations, histopathological
examination is still the gold standard to establish a denitive diagnosis and for conrmation of the nature and origin of oral
lesions.
THEMATIC CONTENT ANALYSIS OF OPEN ENDED QUESTION IN A STUDY TO EVALUATE EFFICACY OF EDUCATIONAL PROGRAM ON KNOWLEDGE AND PRACTICES OF BIOMEDICAL WASTE HANDLERS IN A MEDICAL COLLEGE
Authors: Singh Bharat , T Chandrasekhara , J Kalita Bhaskar , Patel Kushagra
Published: January 2022

AIMS: To carry out Thematic Content Analysis of open ended question in a study to evaluate efcacy of
educational program on knowledge and practices of Biomedical Waste Handlers in a medical college
Study design: Exploratory study
Place and Duration of Study: Armed Forces Medical College Pune from June 2019 to December 2020
METHODOLOGY: A total of 37 reviews were received. Many answers were in Hindi, Marathi, English and Roman Hindi
(Transliteration of Hindi in Roman Script) and thus were transcribed to English. Useless data was excluded and codication of
data was carried out. Themes were generated from these data and Thematic Content Analysis was carried out.
RESULTS: The themes prominently noticed were “positive feedback of the training program”, “suggestions for better training”,
and “suggestions for better outcomes”. 10% of the feedbacks were appreciative of the Instructor, 10% of the feedbacks were
appreciative of the conduct of class, and 17% of the suggestions revealed that these programs are indeed helpful and created
awareness. 24% of the feedback received revealed that the gain of knowledge from such program is directly associated with
performance. 14% of the feedbacks laid emphasis on Hands on Training, 17% feedback reected that the timing, duration and
initiation of the program should be suited to the participants, and 7% of the suggestions demanded a need for certication of
such a program.
CONCLUSION: Causes for poor participation to offer suggestion should be evaluated to ensure better feedback and also to
know the exact cause of lassitude – whether organic or systematic. Despite a few inadequacies, the program was much
appreciated with a positive peer to peer feedback.
A PROSPECTIVE STUDY OF FUNCTIONAL AND RADIOLOGICAL OUTCOME OF PERTROCHANTERIC FEMUR FRACTURES TREATED WITH PROXIMAL FEMORAL NAIL ANTI ROTATION II ( PFN A2)
Authors: Maneesh Chandra Kannelli , Kumar A Sandeep , Dinesh Mudra
Published: January 2022

BACKGROUND: Femoral Inter-Trochanteric fracture is one of the most frequently occurring fractures in the elderly,
usually following trivial trauma. In the younger age group of people, it occurs almost always due to high velocity trauma.
OBJECTIVES: This study aimed to study the functional and radiological outcomes of operative management of
intertrochanteric fracture treated by PFN-A2.
MATERIAL & METHODS: A prospective study of 20 cases of intertrochanteric femur fracture treated by PFN-A2,
minimum 6 months of follow up. All cases are evaluated according to Modified Harris Hip Score on residual effects on
clinical ground at final examination. Pain & functional capacity are the two basic considerations for this scoring system.
Points are given for pain, function, range of motion & absence of deformity.
RESULT: Functional result according to Modified Harris Hip score was found to be excellent in 11(55%) patients, good in
5(25%) patients, fair in 3(15%) patients & poor in 1(5%) patients. poor outcome occurs due to development of
complications.
CONCLUSION : PFN A2 has the advantage of minimal incision, shorter operative time, rapid rehabilitation, lower
medical complications among other options.
A PROSPECTIVE STUDY TO EVALUATE THE FUNCTIONAL OUTCOME OF NON- INSTRUMENTED LUMBAR DECOMPRERSSION IN ADULT DEGENERATIVE LUMBAR CANAL STENOSIS [LCS] AND DETERMINE PREDICTIVE FACTORS OF FAVOURABLE OUTCOME
Authors: Prasad Rakesh , N Prasad Sunny
Published: January 2022

AIM AND OBJECTIVES: A prospective study to evaluate the functional outcome of non- instrumented lumbar
decompression in adult degenerative lumbar canal stenosis [LCS] and determine predictive factors of favourable
outcome.
Study details: Patients attending Orthopedic OPD at BARC Hospital, Mumbai, who were operated for adult degerative
LCS from June 2017 to May 2019.
CONCLUSION: The VAS and Beaujon score were stasistically significant when compared to preoperative and 3
months post operatively
DEVELOPMENT AND STANDARDISATION OF SEXUAL SATISFEACTION SCALE
Authors: Abhilash Simple , Neelakandan R. , Jayaraj B.
Published: January 2022

The aim of this study is to develop a comprehensive,valid,and reliable tool to measure the level of sexual satisfaction of
married men and women and has been named as Sexual Satisfaction Scale (SSS).Initially, the item selection was done
based on the past literature and on interviews of 30 happily married couples.Secondly,administration of questionnaire
in 23 married male and females were done and thirdly,administration of draft was done in 200 married male and female
in age ranging 20 - 60 in different cities of Kerala.The reliability established was 0.78 and validity was 0.69.
DO ADIPOSITY INDICES INFLUENCE VO2 MAX WITHIN NORMAL LIMITS? FITNESS VS. FATNESS
Authors: M. Hattiwale Haroon Rashid , H. Hattiwale Shaheenkousar , Dhundasi Salim A. , Ahmed Mohammad Muzammil , Nazeer Mohammed , Mohd Amir Khwaja
Published: January 2022

Introduction: The global burden of obesity doubled in children, tripled in adolescents and adults between 1975 and
2016.The central obesity is strongly associated with risk of type 2 diabetes and coronary artery diseases.Therefore,it is
important to screen/detect obesity and its complications in early stages.Aim: of this study is to evaluate early markers of
adult overweight/obesity, visceral obesity and aerobic fitness in young, healthy men, and also to find out association
between visceral obesity and VO max as adequate research data is not available in this field. Forty young, 2 Methods:
healthy adult men (aged 18-40 years) were randomly selected from the population of Vijayapura,Karnataka,India,in this
study. The anthropometric parameters; weight, height, BMI, BSA, waist circumference and hip circumference were
measured. The waist-hip ratio, Conicity index and A Body surface Index were calculated.VO max was measured by 2
Rockport 1-Mile walk test. A series of Pearson's correlation tests were performed to find out the influence of visceral
adiposity indices on aerobic fitness. Results: All anthropometric parameters and adiposity indices measured in our
study were within the normal range.A significant positive correlation was observed between age vs conicity index and
age vs ABSI.We also found a significant negative correlation between adiposity indices and VO max in young healthy 2
adult males. Conclusion: Waist circumference, waist-hip ratio, conicity index and ABSI can be considered as useful
anthropometric tools to diagnose central/visceral obesity in healthy men with normal BMI.Total fat and visceral fat may
probably have some negative influence on cardiorespiratory function and aerobic fitness.
EXTENT OF ANXIETY AND STRESS AMONG HEALTH CARE WORKERS IN THE STATE OF SIKKIM
Authors: Sengupta Lahiri Arunima , Sherpa Nima Norbu , Bhutia Tenzing Sangay
Published: January 2022

The purpose of this study is to determine the level of anxiety and stress among different groups of Sikkim's health-care
workers, based on gender and previous exposure to ICU duties. The current study's sample included 152 HCWs who
were chosen via stratified random sampling. The anxiety and stress dimension of the Depression Anxiety and Stress
Scale (DASS-21) was used to assess anxiety and stress. Based on gender and previous exposure to ICU duty, different
groups of health care workers were found to have varying levels of anxiety and stress.
Design of In-phase and Quadrature Two Paths Space-Time-Modulated Metasurfaces
Authors: Li Mengmeng , Li Mengmeng , Bilotti Filiberto
Published: January 2022

Space-time-modulated metasurfaces can manipulate electromagnetic waves in space and frequency domain simultaneously. In this paper, an analytical design of space-time- modulated metasurfaces with modulation elements composed of two paths, In-phase (I) and Quadrature (Q), is proposed. The model is derived analytically, the space/frequency domain manipulations are achieved by designing the dimension and time sequence of I and Q paths. In the specular reflection direction, an objective frequency shift of the reflected first order harmonic can be obtained. While, in other directions, the opposite first order harmonic can be easily controlled by changing the dimension of I/Q paths and the objective first order harmonic remains unchanged. Furthermore, with a small dimension of I/Q paths, the first order harmonic can be used for beam scanning by pre-designing the start time of the modulation element. To realize the space-time-modulated metasurface with the required periodically time-varying responses, 2-bit unit-cells loaded with dynamically switchable pin diodes are employed as I/Q modulation. Both analytical and numerical results demonstrate that space and frequency domain manipulations of the reflected fields by the first order harmonics can be simultaneously obtained. The proposed designs have potential applications in wireless communications, radar camouflaging, and cloaking.
Development and Validation of Digital Literacy Scale (DLS) and its Implication for Higher Education
Authors: Hina Amin  , Muhammad Abid Malik  , Bulent Akkaya
Published: January 2022

The study aimes to develop and validate Digital Literacy Scale (DLS) based on Chen’s (2015) theoretical framework which includes nine dimensions: communication, collaboration, critical thinking, creativity, citizenship, character, curation, copyright, and connectedness. A question pool consisting of 62 items based on the nine dimensions of digital literacy was generated on a 5-point Likert-type scale. Content validity of the question pool was sought from experts in terms of clarity of items, language understanding, and relevance. SPSS and AMOS were used for statistical analysis. Using a sample of 349 university students, Exploratory Factor Analysis was employed for reliability analysis, construct validation, and factor structure of the scale. EFA confirms the nine dimensions; however, some items were deleted during this process. Finally, Confirmatory Factor Analysis was employed to check the reliability and validity of the factor structure by using a second sample (n=442). CFA showed that all the values were within the acceptable range (Kaiser-Meyer-Olkin 0.886, the total variance explained 62.87%, Cronbach Alpha 0.894, and the goodness of fit 0.924). Thus a standardized DLS consisting of 36 items and 9 factors (communication, copyright, critical thinking, character, citizenship, curation, connectedness, creativity, and collaboration) was finalized. DLS is a psychometrically sound, reliable, and valid measurement tool that can be used to measure digital literacy.
TRADISI BUDAYA DAN KEARIFAN LOKAL PAULAK UNE DAN MANINGKIR TANGGA PADA PERNIKAHAN BATAK TOBA DI DESA SIGAPITON KECAMATAN AJIBATA: KAJIAN ANTROPOLINGUISTIK
Authors: Situmorang Optapianty , Sibarani Robert
Published: January 2022

Penelitian ini bertujuan untuk mengetahui tradisi Budaya dan Kearifan Lokal Paulak Une dan Maningkir Tangga pada pernikahan Batak Toba di Desa Sigapiton Kecamatan Ajibata. Riset ini betujuan untuk mendeskripsikan Tradisi Budaya dan Kearifan Lokal Paulak une dan Maningkir Tangga pada pernikahan dalam siklus kehidupan Batak Toba, Mendeskripsikan Performansi (Indeksiskalitas dan Partisipasi) tradisi Paulak Une dan Maningkir Tangga pada Pernikahan Batak Toba, Mendeskripsikan Kearifan Lokal yang terdapat dalam tradisi Paulak Une dan Maningkir Tangga pada pernikahan Batak Toba. Teori yang digunakan untuk menganalisis informasi riset ini merupakan teori antropolinguistik mencakup tradisi lisan, kearifan lokal, konsep Performansi (Indeksikalitas dan Partisipasi). Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Hasil dari penelitian ini adalah: Terdapat 14 tradisi perrnikahan Batak Toba diantaranya termasuk Paulak Une dan Maningkir Tangga,terdapat 3 Performansi, 4 partisipasi, 5 indeksikalitas, dan 8 jenis kearifan lokal.
PENINGKATAN KETERAMPILAN MENULIS PANTUN MELALUI MEDIA GAMBAR PADA SISWA KELAS VIII SMP HKBP SIDIKALANG
Authors: Putri Yowana , Lubis Ramadhan Saleh , Saragih Resi Masna Warni , Sitorus Anggreini , Simarmata Farida Br
Published: January 2022

Penelitian ini bertujuan untuk meningkatkan keterampilan menulis pantun melalui media gambar. Data yang peneliti ambil bersumber dari kelas VIII 1 SMP Swasta HKBP dengan jumlah 30 siswa. Jika dilihat dari hasil tes, masih ada siswa yang belu memahami langkah-langkah dan kaidah menulis pantun. Siswa masih kesulitan menuangkan ide-ide serta kosa kata yang mereka miliki. Penelitian ini adalah jenis PTK dengan menggunakan media gambar dan teknik pengumpulan data dengan observasi dan tes. Hasil penelitian menunjukkan bahwa proses peningkatan keterampilan menulis pantun melalui media gambar mengalami peningkatan. Hal ini dapat dilihat dari hasil rata-rata setiap siklus, pada tahap prasiklus hanya mencapai rata-rata 69,1 dan belum mencapai indikator. Namun, terjadi peningkatan pada siklus I dengan rata-rata 79,5 dan pada siklus II terjadi peningkatan kembali dengan rata-rata 82,7. Dengan ini peneliti menyatakan bahwa pembelajaran menulis pantun melalui media gambar dapat meningkatkan keterampilan siswa dalam menulis pantun.