bluuebunny/crossref_metadata_2025 huggingface dataset:
The CBIT+TMS Trial: study protocol for a two-phase randomized controlled trial testing neuromodulation to augment behavior therapy for youth with chronic tics
Authors: Conelea Christine , Greene Deanna , Alexander Jennifer , Houlihan Kerry , Hodapp Sarah , Wellen Brianna , Francis Sunday , Mueller Bryon , Hendrickson Timothy , Tseng Angela , Chen Mo , Fiecas Mark , Lim Kelvin , Opitz Alexander , Jacob Suma
Published: June 2023

Background: Comprehensive Behavioral Intervention for Tics (CBIT) is a first-line treatment for tic disorders that aims to improve controllability over tics that an individual finds distressing or impairing. However, it is only effective for approximately half of patients. Supplementary motor area (SMA)-directed neurocircuitry plays a strong role in motor inhibition, and activity in this region is thought to contribute to tic expression. Targeted modulation of SMA using transcranial magnetic stimulation (TMS) may increase CBIT efficacy by improving patient ability to implement tic controllability behaviors.
Methods: The CBIT+TMS trial is a two-phase, milestone driven early-stage randomized controlled trial. The trial will test whether augmenting CBIT with inhibitory, noninvasive stimulation of SMA with TMS modifies activity in SMA-mediated circuits and enhances tic controllability in youth ages 12-21 years with chronic tics. Phase 1 will directly compare two rTMS augmentation strategies (1Hz rTMS vs. cTBS) vs. sham in N = 60 participants. Quantifiable, a priori “Go/No Go Criteria” guide the decision to proceed to Phase 2 and selection of the optimal TMS regimen. Phase 2 will compare the optimal regimen vs. sham and test the link between neural target engagement and clinical outcomes in a new sample of N = 60 participants.
Discussion: This clinical trial is one of few to date testing TMS augmentation of therapy in a pediatric sample. Results will provide insight into whether TMS is a potentially viable strategy for enhancing CBIT efficacy and reveal potential neural and behavioral mechanisms of change.
Trial registration: ClinicalTrials.gov Identifier: NCT04578912. Registered October 8, 2020. https://clinicaltrials.gov/ct2/show/NCT04578912
Forming mechanism of leaf-like integral outside finned tubes by a combination method of knurling and cutting-bending
Authors: Zou Yang , Tang Kairui , Guo Guiqing , Tang Yong
Published: June 2023

A combination method of knurling and cutting-bending is proposed to manufacture leaf-like integral outside finned tubes (LIOFT). The numerical analysis method was used to explore the material fracture and plastic forming processes. Single-factor experiments were used to establish quantitative relationships between process parameters and forming quality to guide the design of experimental parameters. The results of the numerical analysis revealed that the teeth of the knurled tube were cut by the tool's main cutting edge and then slide-bent along the rake face and minor cutting edge during the forming process. The knurling direction significantly affects the fin height and shift, a reasonable knurling direction increases the fin height by 40.1% while reducing the fin shift by 94.0%. Increasing the friction coefficient and tool feeding speed slightly increases the fin height but reduces the fin strength and finning ratio. The combination of experimental parameters was optimized based on the numerical analysis results, and a LIOFT with a maximum fin height of 3.46 mm was manufactured accordingly.
Air pollution and thyroid abnormalities: Systematic review and meta-analysis
Authors: Rohani Farahnaz , Rezayat Arash Akhavan , Rohani Behnaz , Liaghat Amirreza , Najafi Sara , Jafari Niloufar , Rezayat Shima Akhavan , Joulaei Hasan
Published: June 2023

Background Air pollution exposure can trigger a wide range of thyroid dysfunction in different population groups. This systematic review and meta-analysis aimed to find the association between air pollution and thyroid dysfunction in the general population and neonate, pregnant and cancerous people. Methods Electronic databases, including Web of Science, PubMed, Scopus, and Embase, were searched for all published articles from 27 October 2021. The Newcastle Ottawa Scale checklist was used to assess the quality of individual studies. Relevant demographic data and the intended results of the selected studies were extracted, and their adjusted odds ratios were pooled using random and fixed effect analysis based on the heterogenicity index. Results After applying the search strategies, twenty-six articles were included in our study. Overall, the association between air pollution and thyroid cancer, neonatal hypothyroidism, maternal thyroid function, and thyroid function in the general population was discussed in four, eight, ten, and four studies, respectively. There was a significant association between PM2.5exposure and maternal hypothyroxinemia with pooled OR of 1.241 (95%CI, 1.089–1.415), p-value < 0.001. No positive relationship existed between NO2 exposure and maternal hypothyroxinemia with pooled OR of 1.007 (95%CI, 0.840–1.207), p-value = 0.941. The investigation of the relationship between PM2.5exposure and congenital hypothyroxinemia showed a significant association between them, with pooled OR of 1.017 (95%CI, 1.002–1.032), p-value = 0.024. Conclusions Air pollution could influence thyroid function, especially in pregnant women and newborn infants. This study and similar investigations provide evidence of air pollution toxicity for healthcare systems.
Effect of He 2+ Ion Irradiation on the Mechanical Properties of Automated Fibre Placement (Afp) Cf-peek Thermoplastics Composites
Authors: Oromiehie Ebrahim. , Nair Vishnu , Short Ken. , Wei Tao. , Bhattacharyya Dhriti. , Prusty B. Gangadhara
Published: June 2023

Carbon fiber-reinforced polyetheretherketone (CF-PEEK) composites have gained significant usage across diverse industries like automotive and aerospace due to their desirable characteristics. These properties encompass recyclability, low density, high strength, wear resistance and thermal stability. High fluence ion irradiation is of interest for fundamental reasons and for potential applications in aerospace industry, as the components will be subjected to a high radiation environment once they escape the earth’s atmosphere. The ion irradiation of CF-PEEK is accompanied by radiation-induced effects, which drastically change the structure and properties of irradiated material. Since the resistance of CF-PEEK to radiation damage has not been studied extensively, this study aims to understand the effect of high-energy He2+ ions on the microstructure and properties of CF-PEEK composites manufactured using automated fibre placement (AFP) under different processing conditions. The samples have been radiated with 5 MeV He2+ ions using an energy degrader wheel to create a layer with relatively uniform damage. Then, were characterized using optical and scanning electron microscopy and their hardness was evaluated using nanoindentation. It was observed that, irradiation increases the hardness of the fibres in all cases. Also, fibre orientation affects the hardness in a statistically significant manner in both unirradiated and irradiated conditions.
Integrating climate adaptation strategies in spatial decision support systems
Authors: Povak Nicholas A. , Manley Patricia N. , Wilson Kristen N.
Published: June 2023

With the onset of rapid climate change and the legacy of past forest management and fire suppression policies, the capacity for forested landscapes to maintain core functionality and processes is being challenged. As such, managers are tasked with increasing the pace and scale of management to mitigate negative impacts of future large disturbances and improve resilience and climate adaptation of large landscapes. Such an effort will require consensus building, with partners and stakeholders to determine where to allocate scarce resources. We present a methodology to identify strategic (where to go) and tactical (what to do) priorities across large landscapes to assist in project level planning. The model integrates a spatial assessment of current ecological and resource conditions and spatial outputs from a landscape succession and disturbance simulation model (LANDIS-II) to assess the potential to achieve desired conditions under climate change with ongoing disturbances. Based on the expected trajectory of landscape conditions over time, the model applies multivalent reasoning (aka, fuzzy logic) to provide spatial decision support for four management strategies (Monitor, Protect, Adapt, and Transform) across the landscape. We apply these methods to a 970,000-ha landscape in the central Sierra Nevada Mountains of California with a focus on managing for improved carbon sequestration. By including future landscape conditions in the model, decisions made at the stand-level are inherently tied to and influenced by larger landscape-level processes that are likely to have the greatest influence on future landscape dynamics. Evaluations are adaptable to incorporating multiple metrics to capture the many resources management can influence such as forest resilience, fire dynamics, biodiversity conservation, and carbon sequestration. Model outputs could also be used as inputs into optimization models to assess tradeoffs and synergies between these conditions and resources, technical and economic feasibilities, and to develop long-term management plans.
Tuning optical, dielectric, and electrical properties of Carboxymethyl cellulose (CMC) doped with Cobalt ferrite (CoFe2O4) nanoparticles via laser ablation for flexible electronic devices
Authors: Menazea Abdelrhman A. , El-Morsy M. A.
Published: June 2023

The authors have requested that this preprint be removed from Research Square.
Unveiling the structure of umbu tree dispersal units through x-ray imaging
Authors: Rodrigues Allana Mellyse Barbosa , Torres Maria Fernanda Oliveira , Nunes Valdinete Vieira , Souza Juliana Lopes , Santana Natali Aparecida , MANN RENATA SILVA
Published: June 2023

Characterizing dispersal structures is crucial for species identification and selecting diverse germplasm. This study aimed to investigate the morphology of Spondias tuberosa dispersion units and assess the efficacy of x-ray imaging in characterizing their internal morphology. X-ray imaging successfully revealed the internal structures, enabling the identification of filled, translucent, malformed, and empty seeds. The morphological analysis provided valuable insights into the dispersal units and presented a non-destructive and efficient method for future germplasm studies.
Energy scheduling based-two layers interval optimization in a smart energy hub system with multi-performance of the hydrogen storage system and demand side management
Authors: Javid Seyed Saeed Mosayebi , Derakhshan Ghasem , Hakimi Seyed mehdi
Published: June 2023

A smart energy hub (SEH) is one of the significant opportunities in smart grids as a distinguished framework for optimal energy consumption and generation. The energy price uncertainty in energy markets for energy optimization is the main challenge for achieving economic modeling of energy consumption and generation. This paper proposes optimal energy scheduling in a SEH under uncertainty of electricity prices in the day ahead in the energy market. The proposed optimization approach is implemented by a two-layer interval approach considering uncertainties for minimizing energy generation cost. In first layer optimization, electrical demand subject to the optimal level of electrical consumption is modified by the demand shifting strategy by using the demand side management (DSM). In second-layer optimization, the interval approach is used for modeling uncertainty; and energy generation cost is converted to Bi-objective functions including average and deviation costs with conflict nature than each other. Also, the multi-performance of the hydrogen storage system based-electrical and natural gas generation is considered for managing uncertainties in second layer optimization. Since the interval optimization approach is proposed in the second layer, minimizing the average cost and deviation cost are formulated as Bi-objective functions by the augmented epsilon-constraint method. In the following, the LINMAP procedure is utilized to achieve maximum compatibility and the best trade-off consequence in the Pareto frontier of the multi-objective functions. Finally, the proposed optimization approach is modeled as a numerical simulation in the three case studies to verify obtained results by implementing the DSM and hydrogen storage system participation.
RETRACTED: Genetic Variability, Correlation and Path Analysis Studies Among Different Tulip Genotypes
Authors: RANA NEPU , Sharma Puja , Dhiman Sita Ram , Kashyap Bharati , Dogra Rajesh Kumar , Sharma Anju , Sharma Poonam
Published: June 2023

The authors have requested that this preprint be removed from Research Square.
TUBERCULOUS MENINGOENCEPHALITIS COMPLICATED BY TUBERCULOUS ABSCESSES IN AN IMMUNOCOMPETENT INFANT: A CASE REPORT
Authors:   Department of Pediatrics A. Child Mother Hospital. CHU Mohammed VI. Marrakech., Maiga O. , Himer J. El ,   Department of Pediatrics A. Child Mother Hospital. CHU Mohammed VI. Marrakech., Traore A.O ,   Department of Pediatrics Reanimation. Child Mother Hospital. CHU Mohammed VI. Marrakech., Mghar S. ,   Department of Pediatrics A. Child Mother Hospital. CHU Mohammed VI. Marrakech., Fakiri K. El ,   Department of Pediatrics A. Child Mother Hospital. CHU Mohammed VI. Marrakech., Rada N. ,   Department of Pediatrics A. Child Mother Hospital. CHU Mohammed VI. Marrakech., Draiss G. ,   Department of Pediatrics A. Child Mother Hospital. CHU Mohammed VI. Marrakech., Younouss Said ,   Department of Pediatrics Reanimation. Child Mother Hospital. CHU Mohammed VI. Marrakech., Bouskraoui M. ,   Department of Pediatrics A. Child Mother Hospital. CHU Mohammed VI. Marrakech.
Published: June 2023

Central nervous system tuberculosis is a major cause of morbidity and mortality in developing countries. Intracranial tuberculoma is rare and is one of the most serious cases of tuberculosis. We report a case of tuberculous meningoencephalitis complicated by tuberculous abscesses, in a 10-month-old boy with angina and otorrhea 42 days ago. A CT scan of the brain and Rochers TDM showed aggressive bilateral otomastoiditis, more marked on the left, multiple left supratentorial brain formations with subfactorial and temporal involvement in relation to abscesses. Mycobacterium tuberculosis was isolated in the CSF fluid and in the brain pus after surgical drainage. Good clinical and radiological improvement was observed after surgery and treatment with corticosteroids and antituberculosis drugs.
HUMAN RESOURCE MANAGEMENT AND ORGANIZATIONAL PERFORMANCE
Authors:   Doctor of Business Administration (D.B.A.) in Management, Founder and CEO, Biotech Industries Co., Ltd., Thailand., Khuay Guan Lionel Lee , Channuwong Sukhumpong ,   Chairman of Academic Committee, Doctor of Philosophy (Ph.D.) in Modern Organizational Management, Faculty of Liberal Arts, Krirk University, Thailand., Wongmajarapinya Kulpornpath ,   Doctor of Philosophy (Ph.D.) in Modern Organizational Management, Founder and CEO, Thai Smile Bus Company Limited, Thailand.
Published: June 2023

Human resource management is one of the most important components to increase organizational performance. This is because human resources are the most valuable assets that can drive the organization to grow and prosper, and to be able to compete in the global market. This paper aimed to study the important components of human resource management and a linkage between human resource management and organizational performance based on the literature review. The results of the study showed that human resource management can help the organization to elicit and extract knowledge, skill, expertise, talent and competency of employees to work for the success and growth of the organization. Without effective human resource management, the organization cannot run its business to reach its goals and objectives. Therefore, each organization focuses on recruiting and selecting knowledgeable, skillful and competent employees and pay them with fair benefits and compensation to create their organizational commitment so that that they work to increase organizational performance. In addition, the organization should train unknowledgeable and unskillful employees to have more knowledge and skills required to work for the organization.
GLUOSE 6-PHOSPHATE ISOMERASE DEFICIENCY: A RARE ENTITY
Authors: Thakkar Simran , Padwal Namita , Karnik Niteen
Published: June 2023

A young male presented to us with the chief complaints of jaundice, non-bilious vomiting and intermittent high-grade fever in the background of past history of recurrent blood transfusions.On examination, he had pallor, icterus with a massive non tender splenomegaly and his laboratory parameters were suggestive of indirect hyperbilirubinemia with low haptoglobin and elevated lactate dehydrogenase levels with reticulocytosis and erythroid hyperplasia on bone marrow aspiration. His Direct and indirect coombs test were negative.To rule out hemoglobinopathies, his hemoglobin electrophoresis was sent, which turned out to be normal. Hence, red blood cell membrane and enzyme studies were carried out which revealed Glucose-6-phosphate isomerase deficiency.
ASSESSING AWARENESS OF BASIC LIFE SUPPORT AMONG NURSING STAFF WORKING IN THE WARD (S) OF A LEADING TERTIARY CARE CENTER IN KOLKATA: A CROSS-SECTIONAL AUDIT
Authors:   Department of Emergency Medicine, Peerless Hospitex Hospital and Research Centre Limited, Kolkata, India., Priya Amrutha , Hazra Darpanarayan ,   Department of Emergency Medicine, Peerless Hospitex Hospital and Research Centre Limited, Kolkata, India., Dasgupta Indraneel ,   Department of Emergency Medicine, Peerless Hospitex Hospital and Research Centre Limited, Kolkata, India.
Published: June 2023

A profound understanding of BLS is crucial for nursing staff assigned to the general ward in a hospital. Consistently staying updated will enable early identification of sick patients, leading to better patient outcomes. Making regular audits and mandatory monitoring of nurses knowledge of BLS will ensure enhanced quality of care.
TYPES OF SUBSTANCE USES AMONG SAUDI FEMALE USERS IN JEDDAH, KINGDOM OF SAUDI ARABIAFROM 2008 TO 2017: CASE - CONTROL STUDY
Authors:   Administration of Public Health in Jeddah, Ministry of Health, Saudi Arabia., A. Khalawi Alaa , Alsahafi Abdullah ,   Administration of Public Health in Jeddah, Ministry of Health, Saudi Arabia., Algarni Abdullah ,   Administration of Public Health in Jeddah, Ministry of Health, Saudi Arabia., K. Filemban Maimona ,   Administration of Public Health in Jeddah, Ministry of Health, Saudi Arabia., A. Bakhsh Eman ,   Administration of Public Health in Jeddah, Ministry of Health, Saudi Arabia., A. Alqusibri Asmaa ,   Model of Care in Medina Health Cluster, Ministry of Health, Saudi Arabia., A. Subke Abeer ,   Saudi Board for Preventive Medicine in Jeddah, Ministry of Health, Saudi Arabia., Alhaeli Alaa ,   Administration of Public Health in Jeddah, Ministry of Health, Saudi Arabia., Hawsawi Taghreed ,   Administration of Public Health in Jeddah, Ministry of Health, Saudi Arabia., A. Khalawi Yaseen ,   Uhud Hospital, Madinah Health Complex, Ministry of Health, Saudi Arabia., F. Alhejaili Fawaz ,   Directorate of Health Affairs in Jeddah, Ministry of Health, Saudi Arabia., Alahmadi Bayan ,   Madinah Health Cluster, Network Executive Management, Ministry of Health, Saudi Arabia.
Published: June 2023

Background: Substance use is a major public health problem, necessitating further investigation in Saudi Arabia. This research was carried out to evaluate the patterns of substance use among Saudi women. Method:This was a case-control studyconducted in Jeddah. Data was collected and analyzed using Chi-square tests. Results: The mean age of the cases (meanÂ± SD) was 29.9Â±10.9 years, while that of controls was 33.7Â±10.9 years. Most (71%) cases were smoking nicotine, (61.8%)using cannabis, and (47.3%) using amphetamine. Most of them were single (37%), separated (4.8%), or divorced (24.2%). More cases than controls were likely to have been in multiple marriages (p<0.001), have a lower education level (p<0.001), be unemployed (p<0.001), have a household income of less than 5000 SR (p<0.001), and live in families in conflicts (p<0.001).Tuberculosis (p=0.012), HIV (p=0.036), hepatitis C or B (p=0.044), and sickle cell disease (p<0.001)were more prevalent in cases than controls.Casesalso hada significantly higher prevalence of schizophrenia, depression, bipolar and personality disorders (all p<0.001) than controls. Conclusion:These findings indicate the high prevalence of substance use in young Saudi females and the association with socio-economic, demographic, and mental health factors.
Relation between defects in the lumbar spine and the position and dimensions of individual vertebrae in German Shepherds
Authors: DZIERZĘCKA MAŁGORZATA , PAŚKO SŁAWOMIR , WADOWSKA IZA , KOWALUK TOMASZ , ŁUSZCZEWSKA-SIERAKOWSKA IWONA , CHARUTA ANNA
Published: June 2023

The German Shepherd is among the breeds most prone to pathologies of the lumbosacral spine. The aim of the study was to examine how the presence of spine pathology affects the shape of the lumbar spine and dimensions of individual vertebrae. Mathematical analysis consisted of three measurements for each lumbar vertebra. Based on the analysis, it was concluded that there was a correlation between the height of the first five vertebrae and the occurrence of the lumbosacral transitional vertebra (LTV). It was also shown that spondylosis manifested most often with a change in the distance between individual lumbar vertebrae. There was no correlation between the incidence of spondylosis and the height of the vertebral canal. In conclusion, the presence of a LTV significantly changes the dimensions of other vertebrae in the lumbar spine, which can lead to other pathological changes in the vertebral column.
Efficiacy of albendazole and paromomycin treatments against natural Giardia spp. infection in calves
Authors: KÖSE ONUR , KIYICI REYDA , PALA MUSTAFA FURKAN , ADANIR RAMAZAN , KARAAYVAZ BAYRAM KUDRET , KARACA MEHMET , AKKAN HASAN ALTAN
Published: June 2023

The aim of the present study was to evaluate and compare the efficiacy of albendazole and paromomycine treatments against natural Giardia spp. infection in calves. The calves were divided in two groups of six animals each with similar parasitic loads of Giardiaspp. cysts. Albendazole (20 mg/kg) and paromomycin (50 mg/kg) were administrated orally to group A and group P, respectively, for three consecutive days. The efficiacies of drugs evaluated by analyzing the reduction in cyst excretion in native fecal examinations on days 0, 3, 7, 10, 14, 21 and 28. In addition, percentages of reduction for days 3, 7, 10, 14, 21 and 28 according to day 0 were evaluated. The geometric mean of fecal cyst excretion in both groups started to decrease from the 3rd day, in paromomycin group the decrease continued steadily throughout the examination days starting from the 3rd day, despite that in the albendazole group the cyst amount increased in the 7th day and then decreased again. Cyst excretion reached zero in all animals at the 21st and 28th days in group P and group A, respectively. The percentage of reduction started with a high rate of 47.72% on the third day and reached 100% on the 21st day in the paromomycin group. In the albendazole group, the percentage of reduction started with a rate of 35.29% on the third day and reached 100% on the 28th day. As a result, paromomycin was found to be more effective compared to albendazole in terms of both the regularity of the mean cyst reduction and the time it takes for the cyst excretion to reach zero.
State Regulation of the Economy in the Era of War and Revolution
Authors:   James Madison University, Moore Colleen M.
Published: June 2023

I. V. Potkina’s new monograph examines state intervention in the economy during World War I by analyzing legislation enacted by the tsarist and Provisional governments between 1914 and 1917. Her analysis highlights the main areas of economic intervention, the economic priorities of the respective administrations, the quantitative distribution of regulatory activity by year, and the evolution of the legislative process in response to the extraordinary circumstances of wartime. The author concludes that the imperial government regulated the economy effectively during the war and more successfully than its Provisional successor. This conclusion challenges the prevailing narrative of the “backward” autocracy’s mismanagementof the war effort as the primary reason for its collapse and compels a reconsideration of the question: If the tsarist regime efficiently managed the wartime economy, then why was it overthrown? This review focuses on Potkina’s treatment of regulatory policies regarding wartime prohibition and the establishment of fixed prices for necessities to illustrate the discrepancy between official and popular perceptions of the relative success of the state’s interventional measures. Prohibition was greeted with pogroms of premises trading in spirits and cases of poisoning by non-potable substances such as denatured alcohol, and most of the government’s price-fixing resolutions applied only to goods procured for the armed forces, not those sold to the population in the rear. Potkina attributes the causes of the revolution to the disloyalty of public organizations that constituted the liberal political opposition, but this explanation fails to account for the popular dimension of the events of February, which remains a task for future researchers.
Metaphor as a means of describing flavor in the contemporary English-speaking culture
Authors:   HSE University, Nagornaya Alexandra V.
Published: June 2023

The paper presents an analysis of metaphors used to describe flavor in the 21st century English-speaking culture. The analysis is based on the modern theories of taste developed within the Humanities and the most relevant ideas of Metaphor Studies. Among the latter is J.Zinken’s Discourse Metaphor Theory. According to it, metaphor can serve as a framing device, setting conceptual landmarks for oral and written narratives. The research was conducted on the basis of the culinary show MasterChef. The author made a sample of five hundred metaphors, which is representative enough to achieve the main objective of the research: to reveal the patterns of metaphorical activity in conceptualizing flavor and model the metaphoric landscape of flavor. The research shows that the metaphoric landscape of flavor is constructed around several discourse metaphors: flavor is an event, flavor is a dimensional object, flavor is balance, flavor is a living being, flavor is a form of art. Each discourse metaphor can be used as it is, represented in speech by the most typical verbal means. It can also be represented by its subordinate forms. For instance, the subordinate forms for the event metaphor are flavor is motion, flavor is an impact, flavor is an explosion, and others. Genetically different metaphors may be combined within one description conveying different aspects of flavor. Metaphor expands the repertoire of means used for communicating flavor experience and is a full-fledged means of its cognition and verbalization, alongside qualia terms.
Aspects of media communication in social networks
Authors:   Tomsk Polytechnic University, Kobenko Yuriy V.
Published: June 2023

The peer-reviewed two-volume monograph Social Networks: A Comprehensive Linguistic Analysis (2021) is devoted to the study of the existence of language in modern social networks. The first volume covers the general issues of the linguistic study of Internet communication, its linguocognitive and discursive aspects, as well as its characteristic speech genres. The second volume provides a description of linguo-personological, conflictological and linguo-didactic aspects of communication in social networks. Each volume has a predetermined structural sequence: an introduction by the scientific editor, three chapters, and an off-text bibliographiс list. Social networks in today’s world implement mainly the integrative function of language, aimed at overcoming spatio-temporal restrictions. An auxiliary machine translation option provided for major international Internet platforms also aims to remove the language barrier. The disintegrative potential of social networks, as an antinomic pandan of the integrative function, is manifested in the physical isolation and anonymization of users. The leading trends in the intralinguistic nature of media interaction should be recognized as the determination of industry terminologies as well as the hybridization of texts (turning them into hypertexts by supplying hyperlinks, supplying them metacommunicative symbols, etc.). The extralinguistic features include the massive nature of Internet bilingualism. In general, social networks continue the transhumanistic mission of language in the virtual space: to serve as a means of overcoming the negative aspects of being through the mediatization of man and society, which is expressed by such properties of Internet communication as achronism, acentricity (rhizomorphism), hybridity and alinearity.
Mother and adult daughter: The connection between their psychological well-being and the mother’s parental attitudes
Authors:   St. Petersburg State University, Troshikhina Evgenia , Danilova Marina ,   St. Petersburg State University
Published: June 2023

In psychology, attention to the study of human well-being has increased. The question is how psychological well-being transmitted from mother to daughter, if it is. Aim: to study the relation between the psychological well-being and parental attitudes of mothers with the psychological well-being of adult daughters. Hypothesis: psychological well-being is transmitted from mother to daughter both directly and through the mother’s parental attitudes, with the specificity in periods of adulthood. The sample of 111 dyad mother — daughters from Russia included two groups. The first group consisted of daughters 20–25 years (M=22) and mothers 39–50 years (M=45), the second — daughters 26–40 years (M=33) and mothers 51– 65 years (M=56). Methods: Psychological Well-being Scale (Ryff), Satisfaction with Life Scale (Diener), Fordyce Emotions Questionnaire, Rosenberg Self-esteem Scale, Parental Attitude Research Instrument (Schaefer, Bell). Correlation and factor analysis was conducted. Results: in general, the psychological well-being is transmitted from mother to adult daughter directly and through the mother’s parental attitudes towards equality, independence, and acceptance. However, the mother with high components of “life goal” and “positive relationships with others” has a more pronounced authoritarian control over the early-adult daughter. In daughters, this leads to a decrease of the psychological well-being, but to an increase in happiness. The psychological well-being of middle-adult daughter is correlated with that of the mother, both directly and through the mother’s attitudes towards acceptance and independence. The high psychological well-being of the late-adult mother serves as a buffer when faced with her daughter’s separation, allowing finding new aspirations.
Factors of cognitive complexity of test questions in psychophysiological studies
Authors:   St. Petersburg State University, Gorbunov Ivan , Kuprikova Marina ,   St. Petersburg State Institute of Psychology and Social Work
Published: June 2023

The paper presents the results of a study of the functional state evaluations of the brain during auditory perception. The subjects listened 60 questions with different linguistic characteristics, taken from polygraph database templates, and answered to them. This characteristics: is the number of different types of words, the percentage of words from different parts of speech, the number of negations, the presence of forms of personal pronouns and their place in the question, the number of letters, the percentage of vowels, the position of intonational stress. As psychological characteristics that affect the functional state of the brain, the following were measured: verbal intelligence according to the R.Amthauer’s test, personal and situational anxiety according to the Spielberger — Khanin test. To measure the functional state of the brain, a 19-channel EEG was recorded in the 10–20% system. The functional state of the brain was assessed by calculating the fractal dimension of the EEG using the method. The sample consisted of students and employees of a number of educational institutions in St Petersburg, 9 men and 8 women aged 19 to 59 years. An analysis of the experimental data made it possible to confirm the hypothesis about the influence of the measured questionnaire characteristics, the linguistic characteristics of the questions, and the psychological characteristics of the subjects on the fractal dimension of the EEG. EEG analysis in various leads revealed two EEG “complexity” factors related to the frontal and occipital areas of the brain. A regression model was obtained for assessing the cognitive complexity of a particular test question, which is reflected in the complexity of the EEG curve of the subject perceiving this question. The resulting model allows you to select questions for psychophysiological examination that have the required level of cognitive complexity. The results of the work testify to the importance of such an indicator as the fractal dimension of the EEG for studying the functional state of the brain and its dependence both on the personal and biological characteristics of a person, and on the emotional state and complexity of the information received by the analyzers.
Structural-level organization of conflict competence in the professional activities of a manager
Authors:   Demidov Yaroslavl State University, Kashapov Mergalyas , Lukina Anastasia ,   Demidov Yaroslavl State University, Makhnovets Sergey ,   Tver State University
Published: June 2023

A high level of conflictogenicity in the educational environment, an increase of objective and subjective causes of conflicts, necessitate the formation and development of conflict competence among the heads of educational institutions. The relevance of research in this direction is due to a certain contradiction between the demands of practice for the prevention and resolution of conflicts and the real lack of a description and theoretical justification for the patterns of the structural-level organization of conflict competence. The starting point is the position of the scientific school of V.D. Shadrikov, according to which the implementation of the metasystem approach in line with the theory of systemogenesis makes it possible to explain the features of the development and functioning of complex systems, as well as their structural-level organization. This approach is a development and transformation of the system approach and describes qualitatively different properties of complex psychological systems, which include conflict competence. The purpose of the study is to identify the essential properties and features of the manifestation of the structural-level organization of the manager’s conflict competence. In the course of the study, the methodology “Complex Questionnaire of Metacognitive Potential” (A.A.Karpov) was used. To establish the basic qualities of the leader’s conflict competence, the following methods were used: “Diagnostics of the leading type of response (M.M.Kashapov, T.G.Kiseleva); “Conflict competence” (M.V.Bashkin, V.A.Gorshkova, A.M.Voskresensky). The research was carried out on a sample of 240 directors of educational organizations. For the first time, the essential properties and features of the functional content of conflict competence subsystems were discovered, the interrelationships of the composition of the structural and functional components of conflict competence at the subsystem level of its organization were revealed, the natural relations of the severity of the leading type of response in a conflict situation and the subsystems of metacognitive potential were characterized, and the features of the system-wide level of the structural organization of conflict competence were determined. Taking into account the results obtained contribute to the development of measures to support the heads of educational institutions for the purpose of psychoprophylaxis of their professional destructions.
Statistical quality control based on control charts and process efficiency index by the application of fuzzy approach (case study: Ha'il, Saudi Arabia)
Authors: Ben Khedher Nidhal , Boudjemline Attia , Aich Walid , Zeddini Mohamed Ali , Calderon-Madero Jorge E.
Published: June 2023

Fuzzy methods using linguistic expressions and fuzzy numbers can provide a more accurate examination of manufacturing systems where data is not clear. Researchers expanded fuzzy control charts (CCs) using fuzzy linguistic statements and investigated the current process efficiency index to evaluate the performance, precision, and accuracy of the production process in a fuzzy state. Compared to nonfuzzy data mode, fuzzy linguistic statements provided decision makers with more options and a more accurate assessment of the quality of products. The fuzzy index of the actual process efficiency analyzed the process by considering mean, target value, and variance of the process simultaneously. Inspection of household water meters in Ha'il, Saudi Arabia showed the actual process index values were less than 1, indicating unfavorable production conditions. Fuzzy methods enhance the accuracy and effectiveness of statistical quality control in real-world systems where precise information may not be readily available. In addition, to provide a new perspective on the comparison of urban water and sewage systems, the results obtained from fuzzy-CC were compared with various machine learning methods such as artificial neural network and M5 model tree, in order to identify and understand their respective advantages and limitations.
MILITARY-TECHNICAL COOPERATION BETWEEN ISRAEL AND INDIA: PROSPECTS FOR THE FORMATION OF A STRATEGIC PARTNERSHIP
Authors: Maryasis D. A. , Fedorchenko A. V.
Published: June 2023

Military-technical cooperation (MTC) is an important component of the Israeli-Indian cooperation. This article provides the periodization of the military-technical cooperation of the two countries. Both the factors contributing to the strengthening of bilateral cooperation in this area and the factors that are an obstacle to this are analyzed. A brief overview of the available literature on this topic is provided, while the opinion of not only Israeli and Indian authors directly, but also experts from other countries is studied. The works of Russian researchers are considered separately. The authors come to the conclusion that, despite the mutual interest of the two countries in the development of military-technical cooperation, one should not expect the formation of a strategic alliance between the two countries on the basis of cooperation in this area. A special place in the work is given to the issues of competition between Russia and Israel in the Indian arms market.
Moda ve Reklam Bağlamında ‘‘Nesne Olarak Kadın Bedeni’’ Dönemlere Göre İlişkisel Analiz
Authors: Ergül Güvendi Nurgül
Published: June 2023

Bu makalede kadın bedeninin nesne olarak kullanımının dönemlere göre moda ve reklam sektörü açısından ilişkilerini ortaya koymak amaçlanmıştır. Bu amaçla reklam tarihi ve moda sektörü dönemlere ayrılarak karşılaştırmalı analiz yapılmıştır. Araştırmada veri toplama yöntemi genel tarama modeli olup, verilerin analizinde ise feminist teori ve eleştirel teoriden yararlanılmıştır. Araştırma sonuçlarımıza göre incelenen hemen her dönemde hem reklam hem moda sektöründe kadın bedeninin özellikle cinsel bir araç olarak ön plana çıkarıldığı görülmektedir. Moda ve reklam sektörü arasında görülen ortak özelliklerden birisi de cinsel çağrışımlar için dikkat çekici renklerin (pembe, kırmızı) kadınla özdeşleştirilmesidir. Reklam sektöründe kadın bedeninin konumlandırılma biçiminin moda sektörüne kıyasla çok daha frapan, iddialı, pornografik yaklaşımlarla kurgulandığı söylenebilir. 2000 yılı sonrası ideal kadın bedeni algısını eleştirmeye yönelik moda ve reklam sektöründe görülen yaklaşımlarda ise verilen mesaj açısından kadının metalaştırılmasına bir eleştiri olmasına karşın aslında kadının benzer konularla gündemde kalmasına sebebiyet verilmesidir.
Synthesis, Characterization and Biosafety Evaluation of Hollow Gold
Nanospheres
Authors: Zhang Lu , Zhang Xiao-Yan , Hu Yu-Lan , You Jian
Published: June 2023

Objectives:

In order to assess the biosafety of HAuNS using zebrafish models and the
cancer cell lines HepG2, HEK293, and A549, this study prepared HAuNS in a variety of sizes and
alterations.

Methods:

By oxidizing cobalt nanoparticles encased in gold shells, HAuNS were created. In the
meantime, PEG- and PEI-coated HAuNS were created. The diameters of the HAuNS that were
produced were 30~40 nm, 50~60 nm, and 70~80 nm. MTT assay was used to assess the toxicity of
HAuNS on HepG2, HEK293, and A549 cells. For the investigation of their toxicities, HAuNS
(50~60 nm) of various concentrations were incubated with zebrafish embryos. Then, cell death
was determined using acridine orange staining.

Results:

In a cell line model, it was demonstrated that purified HAuNS exhibit lower toxicity than
unpurified HAuNS. Meanwhile, it was discovered that surface-modified HAuNS was less hazardous
than unmodified HAuNS. Unpurified HAuNS (50–60 nm) exposure to embryos caused deformity
and increased mortality. Moreover, embryos exposed to HAuNS displayed an increase in
cell death, showing that HAuNS can put zebrafish under physiological stress.

Conclusion:

The possible toxicity of HAuNS is now more understood thanks to this investigation.
The details could improve our comprehension of the nanotoxicity of medication delivery systems.
Comparing HAuNS (50~60nm) to the other two particle sizes, its toxicity was quite low. Compared
to unpurified HAuNS, purified HAuNS displayed less toxicity. Comparing PEI-HAuNS and
HAuNS to PEG-HAuNS, cytotoxicity was found to be lower. Our data support the use of pure
HAuNS, HAuNS-PEG, and HAuNS (50~60nm) as possible photothermal conductors when seen
as a whole.
Regulatory Effect of Electroacupuncture on Hypothalamic Serotonin and
its Receptor in Rats with Cerebral Ischemia
Authors: Ma Tongjun , Li Chenyu , Nie Zeyin , Miao Huachun , Wu Feng
Published: June 2023

Background:

Previous studies have shown that the neurological damage caused by
middle cerebral artery occlusion (MCAO) is not only limited to local infarction but can also cause
secondary damage in distant sites, such as the hypothalamus. 5-hydroxytryptamine (5-HT)/ 5-HT
transporter (5-HTT) and 5-HT receptor 2A (5-HT2A) are important in the treatment of cerebrovascular
diseases.

Objective:

This study aimed to study the effect of electroacupuncture (EA) on the expression of 5-
HT, 5-HTT, and 5-HT2A in the hypothalamus of rats with ischemic brain injury and to explore the
protective effect and potential mechanism of EA on the secondary injury of cerebral ischemia.

Methods:

Sprague-Dawley (SD) rats were randomly divided into three groups: sham group, model
group, and EA group. The permanent middle cerebral artery occlusion (pMCAO) method was used
to induce ischemic stroke in rats. In the EA group, the Baihui (GV20) and Zusanli (ST36) points
were selected for treatment, which was administered once per day for two consecutive weeks. The
neuroprotective effect of EA was evaluated by nerve defect function scores and Nissl staining. The
content of 5-HT in hypothalamus was detected by enzyme linked immunosorbent assay (ELISA),
and the expression of 5-HTT and 5-HT2A were detected by Western blot.

Results:

Compared with that in the sham group, the nerve defect function score in the model group
rats was significantly increased, the hypothalamus tissue showed obvious nerve damage, the levels
of 5-HT and the expression of 5-HTT were significantly reduced, and the expression of 5-HT2A
was significantly increased. After 2 weeks of EA treatment, the nerve defect function scores of
pMCAO rats were significantly reduced, the hypothalamic nerve injury was significantly reduced,
the levels of 5-HT and the expression of 5-HTT were significantly increased, and the expression of
5-HT2A was significantly decreased.

Conclusion:

EA has a certain therapeutic effect on hypothalamic injury secondary to permanent
cerebral ischemia, and its potential mechanism may be closely related to the upregulation of 5-HT
and 5-HTT expression and the downregulation of 5-HT2A expression.
Predicting Antitumor Activity of Anthrapyrazole Derivatives using
Advanced Machine Learning Techniques
Authors: Gackowski Marcin , Pluskota Robert , Koba Marcin
Published: June 2023

Background:

Anthrapyrazoles are a new class of antitumor agents and successors to
anthracyclines possessing a broad range of antitumor activity in various model tumors.

Objective:

The present study introduces novel QSAR models for the prediction of antitumor activity
of anthrapyrazole analogues.

Methods:

The predictive performance of four machine learning algorithms, namely artificial neural
networks, boosted trees, multivariate adaptive regression splines, and random forest, was studied
in terms of variation of the observed and predicted data, internal validation, predictability,
precision, and accuracy.

Results:

ANN and boosted trees algorithms met the validation criteria. It means that these procedures
may be able to forecast the anticancer effects of the anthrapyrazoles studied. Evaluation of
validation metrics, calculated for each approach, indicated the artificial neural network (ANN)
procedure as the algorithm of choice, especially with regard to the obtained predictability as well
as the lowest value of mean absolute error. The designed multilayer perceptron (MLP)-15-7-1
network displayed a high correlation between the predicted and the experimental pIC50 value for
the training, test, and validation set. A conducted sensitivity analysis enabled an indication of the
most important structural features of the studied activity.

Conclusion:

The ANN strategy combines topographical and topological information and can be
used for the design and development of novel anthrapyrazole analogues as anticancer molecules.