bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibacterial Activity of Lactic Acid Bacteria Isolated from Fermented Wheat (Hamoum) against Pathogenic Bacteria
Authors: Tabak Souhila
Published: May 2023

In the current study, the physicochemical and microbiological characteristics of this fermented wheat Hamoun were described in detail, as well as the soil properties where this type of wheat was stored. The results showed that the Hamoum had concentrations of the lactic acid of 0.25 g ± 0.03 for the Simeto variety (nine years of storage), as well as 0.13 g ± 0.02 and 0.17 g±0.06 for the Ofanto variety following three and six months, respectively, of storage. The water content varied between 8.3 - 9.7 % for grain and between 10.8- 11.5 % for flour. The ash content of grain and flour of 1.43 ± 0.02 and 1.63 ± 0.26, respectively, was above the normal standards. According to these results, fermented wheat is appropriate for human consumption. The results also showed that the soil where the wheat was stored comprised mainly clay and had an alkaline pH of 8.2. The isolation and identification of fermentable germs showed the presence of lactic acid bacteria belonging to the genera Lactobacillus (59 %), Pediococcus (18 %), Leuconostoc (17 %), and Streptococcus (6 %). The antibacterial activities of isolated acid bacteria against pathogenic germs Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 9027), Bacillus cereus (ATCC 14579), and Staphylococcus aureus (ATCC 43300) reflected the presence of strong antibacterial activity, with 62.5 % positive interactions and 100 % pathogenic bacteria inhibited by Lactobacillus.
Amyloid ß1–42 Peptide Induces Galectin-1S8 O-GlcNAcylation to Lead Microglia Migration
Authors: Arrazola Sastre Alazne , Luque Montoro Miriam , LLavero Francisco , Zugaza José L
Published: May 2023

Protein O-GlcNAcylation has been associated with neurodegenerative diseases such as Alzheimer´s disease (AD). O-GlcNAcylation of Amyloid Precursor Protein (APP) regulates both the trafficking and the processing of the APP through the amyloidogenic pathway, resulting in the release and aggregation of the Aβ1-42 peptide. Microglia clear Aβ aggregates and dead cells to maintain brain homeostasis. Here, using LC-MS/MS we reveal that the Aβ1-42 peptide modifies the microglia O-GlcNAcome. We have identified 55 proteins, focusing our research on Galectin-1 protein, since it is a very versatile protein from a functional point of view. Combining biochemical with genetic approaches we demonstrate that Aβ1-42 peptide specifically targets Galectin-1S8 O-GlcNAcylation via OGT. In addition, this Gal-1-O-GlcNAcylated form, in turn, controls human microglia migration. Given the importance of microglia migration in the progression of AD, this study reports the relationship between Aβ1-42 peptide and Serine 8- O-GlcNAcylation of Galectin to drive microglial migration
Expanded PCR Panel Testing for Identification of Respiratory Pathogens and Coinfections in Influenza-like Illness
Authors: Upadhyay Pallavi , Reddy Jairus , Proctor Teddie , Sorel Oceane , Veereshlingam Harita , Gandhi Manoj , Singh Vijay
Published: May 2023

Respiratory tract infections (RTIs) are one of the main causes of hospitalization and mortality causing substantial economic burden to healthcare systems globally. As opposed to the previous belief that respiratory infections are caused by a single pathogen, studies have shown that most RTIs are a result of a combination of bacterial and/or viral pathogens infecting the host. The clinical manifestation of RTIs is very similar (i.e., syndrome), often showing Influenza-like illness (ILI) symptoms. While COVID-19 has dominated ILI over the past few years, there are many other pathogens that are responsible for ILI. In addition, it is not uncommon to have coinfections with multiple pathogens in patients presenting with ILI and that such coinfections can even exacerbate the disease severity of RTIs. Therefore, an insight into coinfections can help with accurate disease prognosis, patient care management and outcomes. The goal of this study was to identify the different organisms in symptomatic patients presenting with ILI.
Mutations in the PIK3C2B, ERBB3, KIT, and MLH1 Genes and their Relationship with Resistance to Temozolomide in Patients with High-grade Gliomas
Authors: Ortiz Gómez León Darío , Contreras Martínez Heidy Johanna , Agudelo Florez Piedad Matilde , Galvis Pareja David Andrés , Pelaez Ronald guillermo
Published: May 2023

Background. The treatment for patients with high-grade gliomas includes radiation therapy and temozolomide. However, some patients do not respond to temozolomide because they have a methylation reversal mechanism through the enzyme O6-methylguanine-DNA-methyltransferase. This biomarker has been used as a prognostic factor in patients receiving treatment with temozolomide. However, not all patients respond in the same way, which suggests the existence of other genes involved in resistance to temozolomide. Materials and Methods. A group of 31 patients with high-grade gliomas was recruited and were clinically, image pattern, and pathologically characterized. The sequencing of 324 genes related to different types of cancer was performed to detect mutations. Subsequently, a statistical analysis was conducted to determine the mutated genes that were most related to resistance to treatment. Results. The genes related to the second relapse of patients with high-grade glioma after the use of temozolomide according to Stupp protocol and metronomic dose were PIK3C2B, KIT, ERBB3, and MLH1. Conclusions. Considering the results obtained, we suggest that the mutations in the four genes and the methylation of the gene promoter that codes for MGMT protein could be related to the clinical evolution of patients with high-grade gliomas and its response to treatment with temozolomide.
On the Deformation Behavior of Composite “Hen’s Eggshell – Polymer Plomb” under Bending
Authors: Panfilov Peter , Zaytsev Dmitry , Mezhenov Maxim , Grigoriev Sergei
Published: May 2023

Deformation behavior of the composite "hen's eggshell - polymer plomb" under bending is examined. Polymer coating does not change the type of behavior of the composite based on eggshell that continues to be brittle despite the mechanical characteristics of the composite could vary in wide limits for brittle structure. Joining "hen's eggshell – polymer plomb" never crack under loading and, hence, it exhibits the high cohesion strength under stresses applied in these experiments. It seems that the composite "hen's eggshell - polymer plomb" could apply as the substitution of the composite "tooth enamel - polymer plomb" under elaboration of novel restorative materials for dentistry, namely, for estimation of their mechanical properties including cohesive strength.
Study of Changes over Time in Breath Alcohol Concentration and Brain Function Induced by Low-Impact Drinking
Authors: Sato Yuichi , Nagano Kosuke , Kinoshita Fumiya , Touyama Hideaki
Published: May 2023

Currently, Japan’s Road Traffic Act uses the breath alcohol concentration (BrAC), which is the concentration of alcohol in 1 L of breath, to enforce the law. However, 400 drunk driving accidents occurred in 2020 when the BrAC was below 0.15 mg/L, which is legal limit in Japan, and cognitive function may be impaired at this concentration. Therefore, we investigated the effects of alcohol consumption at levels below a BrAC of 0.15 mg/L on cognitive function and its change over time using P300, a type of event-related potential, and the concomitant negative variation (CNV). Beer with a 5% alcohol content was used as the drinking load, and the amount of alcohol consumed was determined using a derivation formula that varied according to the subject’s body weight. Electroencephalogram (EEG) measurements were obtained five times before drinking and 10, 30, 50, and 70 min after, and participants were given a go/no-go task to induce event-related potentials during the measurements. The BrAC was measured immediately before the EEG measurement was performed. The results revealed that the alcohol concentration in the exhaled breath increased significantly (p<0.05) at 10, 30, and 50 min after drinking compared with immediately before. In addition, the P300 latency was significantly prolonged (p<0.05), and the early and late CNV amplitudes were significantly increased (p<0.05) in the event-related potentials during these time periods. Moreover, no significant difference was observed in expiratory alcohol concentration at 70 min post-drinking, but significant changes in event-related potentials still occurred. Therefore, our results suggest that cognitive function is impaired in patients with low levels of alcohol consumption, when the BrAC is below the legal limit, and even when the BrAC recovers after the end of alcohol consumption.
Label Design and Extraction in High-Temperature Logistics Based on Concave Coding and MLFFA-DeepLabV3+ Network
Authors: Zhao Xiaoyan , Zhao Pengfei , Yin Yuguo , Tao Luqi , Yan Jianfeng , Zhang Zhaohui
Published: May 2023

Logistics tracking technology at normal temperature is quite mature, but there are few tracking methods for the high-temperature production process. The main difficulties are that the label materials generally used cannot withstand the high temperature for a long time, and the detection devices are vulnerable to environmental impact. A high-temperature logistics tracking solution was developed for a carbon anode used in an aluminum electrolysis factory. It is based on concave coding and a multiscale low-level feature fusion and attention-DeepLabV3+ (MLFFA-DeepLabV3+) network extraction technique for the coded region of the concave coding. The concave coding is printed on the product as a tag that can endure a high temperature of more than 1,200°C, ensuring its integrity and identifiability. Because there is no obvious color distinction between the coding area and the background, direct recognition is ineffective. The MLFFA-DeepLabV3+ network extracts the coding region to improve the recognition rate. The DeepLabV3+ network is improved by replacing the backbone network and adding of a multiscale low-level feature fusion module and convolutional block attention module. Experimental results showed that the mean pixel accuracy and mean intersection over union of the MLFFA-DeepLabV3+ network increased by 2.37% and 2.45%, respectively, compared with the original DeepLabV3+ network. The network structure has only 11.24% of the number of parameters in the original structure. The solution is feasible and provides a basis for high-temperature logistics tracking technology in intelligent manufacturing.
Effectiveness of Pre-Trained Language Models for the Japanese Winograd Schema Challenge
Authors: Takahashi Keigo , Oka Teruaki , Komachi Mamoru
Published: May 2023

This paper compares Japanese and multilingual language models (LMs) in a Japanese pronoun reference resolution task to determine the factors of LMs that contribute to Japanese pronoun resolution. Specifically, we tackle the Japanese Winograd schema challenge task (WSC task), which is a well-known pronoun reference resolution task. The Japanese WSC task requires inter-sentential analysis, which is more challenging to solve than intra-sentential analysis. A previous study evaluated pre-trained multilingual LMs in terms of training language on the target WSC task, including Japanese. However, the study did not perform pre-trained LM-wise evaluations, focusing on the training language-wise evaluations with a multilingual WSC task. Furthermore, it did not investigate the effectiveness of factors (e.g., model size, learning settings in the pre-training phase, or multilingualism) to improve the performance. In our study, we compare the performance of inter-sentential analysis on the Japanese WSC task for several pre-trained LMs, including multilingual ones. Our results confirm that XLM, a pre-trained LM on multiple languages, performs the best among all considered LMs, which we attribute to the amount of data in the pre-training phase.
PEMAHAMAN GURU MUDA DAYAH JAMIAH AL-AZIZIYAH TERHADAP IMPLIKASI PRAKTEK KHITBAH DAN PRAKTEK PEMBATALAN KHITBAH (Studi Analisis Menurut Fikih Syafi'iyah)
Authors: Syarkawi Syarkawi , Fazlon Fazlon , Rahmalia Rahmalia
Published: May 2023

Young Master's Understanding Dayah Jamiah Al- Aziziyah  In this research, it is about the extent of understanding of the sermon, because before and after their request (the bride and groom) claimed to have felt that the bride was the right of the bride to do something unusual but the request was continued until the wedding.

This research is contained by using field studies using a qualitative approach with data collection and information and monitoring methods. The method selected in the analysis of information is the reduction of information, information and gathering conclusions. The position of this research was carried out in Dayah Jamiah Al- Aziziyah.

From the results of the study, it can be concluded that, in the application of the cancellation of the sermon, it leads to using the silence method until the person being applied for comes to say the cancellation of the sermon and returns the object that has been given from the applicant with the understanding and also the cancellation is from a natural perspective. Second, in Islamic thought, the application of this sermon is done on the basis of looking good from the field of wealth, religion, generation and good looks or beauty to want a good successor too. Then in the application of the cancellation of the sermon, it is carried out with a good method with the aim of maintaining brotherhood.
DESAIN BARU LOGO HALAL BADAN PENYELENGGARA JAMINAN PRODUK HALAL; ANTARA URGENSI, SENI, DAN ESENSI
Authors: RACHMAN ABDUL , Maemunah Maemunah , Ulpah Mariya
Published: May 2023

This study aims to analyze the urgency, art, and essence of the new halal logo design issued by the Halal Product Assurance Agency (BPJPH) after the enactment of Law Number 33 of 2014 and Government Regulation Number 39 of 2021 concerning the transfer of authority for administering halal certification from LPPOM of Indonesian Council of Ulama to the Halal Product Guarantee Agency (BPJPH). BPJPH's Halal Logo Design reaps the pros and cons of the Muslim community in Indonesia, both in terms of Arabic writing, the shape of the halal logo that resembles a puppet, and the urgency of a total change from the halal logo of the Indonesian Council of Ulama. This research is interesting to study because the halal logo design is a sign of halal certification of a product and is a halal guarantee for Muslim consumers in Indonesia. This study uses a descriptive qualitative method with a normative juridical approach because it discusses regulations related to guaranteeing halal products in Indonesia both in terms of urgency, art, and essence. This study describes that the total change of the halal logo is not urgent to improve the quality of halal product assurance services in Indonesia. BPJPH's halal logo design puts more emphasis on art than Halal writing in Arabic as a sign that the product is "Halal" so it is difficult to read as a "Halal" sign. The essence of the halal logo is as a sign that the product has been certified halal by BPJPH so that the certainty of halal writing is more considered.

Keywords: logo, halal, BPJPH, urgency
منهج تعليم اللغة العربية في المعهد باب السلام موجواجونج جومبانج
Authors: Nasiruddin Muhammad
Published: May 2023

Abstract his study aims to determine the Arabic language learning curriculum, its implementation as well as its advantages and disadvantages in Pondok Pesantren Babussalam Mojoagung Jombang. By using descriptive qualitative research methods, from the two lodges the researcher found differences in terms of the orientation of Arabic learning and teaching materials for students in the field of Arabic. The results of the research are: 1) the Arabic language learning curriculum at the Islamic Boarding School functionally acts as a guide, instrument and benchmarks to determine the success of learning, by fulfilling the curriculum elements, namely objectives, content / teaching materials, learning activities and evaluation. The four elements are arranged according to the needs and levels of students. 2) In implementing the curriculum, there is a special curriculum in accordance with the Arabic language learning orientation at the Islamic boarding school. 3) The strengths of the Arabic language learning curriculum at the cottage are that the curriculum is both designed according to the needs and ability levels of students, namely middle-level students. The drawback of the Arabic learning curriculum at Pondok Pesantren Babussalam Mojoagung Jombang is that there is no learning plan in the form of developing an Arabic syllabus. Meanwhile, the Basussalam Islamic boarding school uses the modern Islamic boarding school model in Arabic language learning Keywords: curriculum, Arabic language learning.  ملخصتهدف هذه الدراسة إلى معرفة المنهج الدراسي في تعليم اللغة العربية، وتطبيقه، ومزاياه ونقصانه في المعهد باب السلام موجوأجونج جومبانج. باستخدام منهج البحث الكيفي والوصفي فوجد الباحث من حيث الاتجاهات في تعليم اللغة العربية ذلك المعهد نتائج الدراسة كما يلي: 1) يساهم المنهج الدراسي لتعليم اللغة العربية في ذلك المعهد وظيفياً كالدليل والوسيلة والمعيار لمعرفة نجاح التعليم، متكامل العناصر من الأهداف والمحتويات والأنشطة التعليمية والتقويم. ويتم هذه العناصر الأربعة للمنهج الدراسي وفقاً لاحتياجات الطلاب ومستوياتهم، 2) هناك التطوير للمنهج الدراسي الخاص في تطبيق المنهج الدراسي لتعليم اللغة العربية يتلائم مع الاتجاهات في تعليم اللغة العربية في ذلك المعهد، 3) تتمثل المنهج الدراسي لتعليم اللغة العربية في ذلك المعهد من ناحية المزايا وهو المنهج الدراسي المصمم وفقاً لاحتياجات الطلاب ومستوى قدراتهم. والنقصان في المنهج الدراسي لتعليم اللغة العربية في المعهد باب السلام جومبانج هو عدم التخطيط التعليمي من القررات الدراسية في عملية التعليم تطويرياً ويستخدم بأسلوب المعهد في تعليم اللغة العربية.        الكلمات الأساسية: المنهج ،تعليم اللغة العربية.
Analisis Tingkat Kepuasan Mahasiswa Terhadap Kualitas Layanan Akademik di Fakultas Ekonomi dan Bisnis Islam IAIN Samarinda
Authors: Komariah Kokom , Tikawati Tikawati
Published: May 2023

This study aims to describe the analysis of the level of student satisfaction with service quality at the Faculty of Economics and Islamic Business, IAIN Samarinda. This research was conducted by distributing questionnaires to 120 students of class 2017 Islamic Economics Department, Faculty of Economics and Islamic Business, IAIN Smarinda, in order to obtain primary data, namely direct information from respondents about what they felt was satisfaction in getting services at the Department of Economics, FEBI IAIN Samarinda. The questionnaire in this study was taken randomly and divided into 5 aspects of customer satisfaction, namely tangible, reliability, responsibility, assurance, empathy and information system aspects. The findings in this evaluation study indicated that the tangible aspect was felt satisfied by the majority of students. Likewise, the aspects of reliability, responsibility, assurance, empathy, and information system were felt satisfied by the majority of students. Even so, there are several aspects of each variable that need to be improved because there are many students who feel dissatisfied and even dissatisfied with the services provided.
PELUANG INVESTASI DANA HAJI PADA INDUSTRI HALAL DI INDONESIA
Authors: Rachman Abdul
Published: May 2023

AbstractThis study aims to determine non-financial alternative investment instruments for the financial management of Hajj in Indonesia, namely the halal industry. This study analyzes the investment opportunities and strategies in the halal industry. This research method is a descriptive research method using secondary data, namely data from the Central Statistics Agency (BPS), the 2019 Global Moslem Travel Index (GMTI) report, Joint Press Release on the Benefits of Hajj Fund Investment for the People (Ministry of Religion, BAPPENAS, MUI, Ministry Communication and Information), What and How to Invest in Hajj Finance BPKH (Hajj Financial Management Agency), State of the Global Islamic Economy Report 2019/20 and other data related to Hajj financial investments in non-financial instruments. The data collection technique carried out by researchers is by using literature research such as searching for academic literature, halal industry literature, statistics. The finding of this research is that the halal industry is one of the best alternative investment instruments because it is productive and sustainable. The Hajj Fund investment strategy in the halal industry can be done in several ways, first is to collaborate with the world's halal industry players, second is to take a role in the halal supply chain system and third is to invest in the sharia economic digitization sub-sector. Keywords: investment, industry, halal, Hajj      AbstrakPenelitian ini bertujuan untuk mengetahui instrumen investasi alternatif non keuangan bagi pengelolaan keuangan haji di Indonesia, yaitu industri halal. Penelitian ini menganalisis peluang dan strategi investasi di industri halal. Metode penelitian ini adalah metode penelitian deskriptif dengan menggunakan data sekunder yaitu berupa data Badan Pusat Statistik (BPS), report Global Moslem Travel Index (GMTI) 2019, Siaran Pers Bersama tentang Manfaat Investasi Dana Haji untuk Umat (Kementerian Agama, BAPPENAS, MUI, Kementerian Komunikasi dan Informasi), Apa dan Bagaimana Investasi Keuangan Haji BPKH (Badan Pengelola Keuangan Haji), State of the Global Islamic Economy Report 2019/20 dan data lainnya yang berkaitan dengan investasi keuangan haji pada instrumen non keuangan. Teknik pengumpulan data yang dilakukan oleh peneliti yaitu dengan menggunakan literature research seperti pencarian literatur akademis, literatur industri halal, statistik. Penemuan penelitian ini adalah industri halal merupakan salah satu instrumen investasi alternatif terbaik karena bersifat produktif dan berkelanjutan. Strategi investasi Dana Haji pada industri halal dapat dilakukan dengan beberapa cara, pertama adalah melakukan kolaborasi dengan pelaku industri halal dunia, kedua adalah dengan mengambil peran dalam sistem rantai suplai halal (halal supply chain system) dan ketiga adalah berinvestasi pada subsektor digitalisasi ekonomi syariah.Kata kunci: investasi, industri, halal, haji
analsisis perilaku konsumtif pegawai wanita muslimah kab. padang lawas dengan gaya hidup sebagi variabel intervening
Authors: Hsb Zuhria Husnia
Published: May 2023

Artikel ini mendiskusikan tentang perilaku konsumtif pegawai wanita muslimah kab. Padang lawas.. Tujuan dari penelitian ini adalah untuk mengetahui penngaruh langsung dan tidak langsung  antara variabel pengetahuan, religiusitas, lingkungan sosial, budaya, religiusitas, dan konsep diri terhadap perilaku konsumtif pegawai wanita muslimah kab. Padang lawasMetode penelitian ini menggunakan pendekatan kuantitatif dengan path analisys dan menggunakan bantuan program SPSS. Dari hasil uji adapun jumlah responden dalam penelitian ini sebnayak 100 orang. Adapun temuan dalam penelitian ini  lingkungan sosial tidak berpengaruh langsung terhadap gaya hidup, budaya, religiusitas dan konsep diri berpengaruh secara langsung terhadap gaya hidup. Selanjutnya lingkungan sosial tidak berpengaruh langsung terhadap perilaku konsumtif sedangkan untuk budaya, religiusitas dan konsep diri berpengaruh langsung terhadap perilaku konsumtif. Sementara itu, secara tidak langsung lingkungan sosial berpengaruh terhadap perilaku konsumtif dan budaya, religiusitas, konsep diri tidak berpengaruh langsung terhadap perilaku konsumtif.dengan tingkat kepercayaan 95% atau tingkat kesalahan sebesar 5 %.
Intensi Berwisata Berbasis TPB (Theory of Planned Behavior) pada Pariwisata Ramah Halal : Keterlibatan Citra Destinasi, Resiko Pandemi dan Kualitas Pelayanan
Authors: Nuzulia Nuzulia
Published: May 2023

Abstract

Indonesia as a country with the largest archipelago which has a Muslim majority population is a country that has the potential to develop Muslim-friendly tourism. In developing Muslim-friendly tourism, in line with the increasing number of visitors to a tourist destination. Several factors can increase visitors to travel. This study aims to determine the effect of destination image, service quality, and pandemic risk on the intention to travel in halal-friendly tourism. This study involved 100 Muslim respondents who came from East Java and outside East Java. The data collection method uses questionnaires that was distributed online. The data analysis method used is SEM (Structural Equation Modeling). The results showed that the variables of destination image and service quality influenced the Muslim community's intention to travel. Meanwhile, the risk of a pandemic does not affect the intention to travel. These three variables were studied with reference to the theory of planned behavior.

Keywords: Intention, Destination Image, Service Quality, Pandemic Risk, TPB

Abstrak

Indonesia sebagai negara dengan kepulauan terbesar yang memiliki penduduk mayoritas muslim merupakan negara yang memiliki potensi dalam pengembangan pariwisata yang ramah muslim. Dalam ,engembangkan pariwisata ramah muslim, selaras dengan peningkatan jumlah pengunjung pada sebuah destinasi wisata. Ada beberapa faktor yang dapat meningkatkan pengunjung untuk berwisata. Penelitian ini bertujuan untuk mengetahui pengaruh citra destinasi, kualitas pelayanan dan resiko pandemi terhadap intensi berwisata pada pariwisata ramah halal. Penelitian ini melibatkan 100 responden beragama Islam yang berasal dari Jawa Timur maupun luar Jawa timur. Metode pengumpulan data menggunakan keusioner yang disebar secara online. Metode analisis data yang digunakan adalah SEM (Stuctural Equation Modelling). Hasil penelitian menunjukkan bahwa variabel citra destinasi dan kualitas pelayanan memberikan pengaruh kepada intensi masyarakat muslim untuk berwisata. Sedangkan resiko pandemi tidak memberikan pengaruh terhadap intensi berwisata. Ketiga variabel tersebut diteliti dengan beracuan pada theory of planned behaviour.

Kata Kunci: Intensi, Citra Destinasi, Kualitas Pelayanan, Resiko Pandemi, TPB
Drivers and Barriers in the Diversification of Airline Business Models in Turkey (1980-2020): An Institutional Logic Perspective
Authors: ADİLOĞLU YALÇINKAYA Leyla
Published: May 2023

The primary objective of this study is to explore the diversification of airline business models in Turkey in four decades and show the link between the reasons and logic behind the diversification from the institutional logic perspective. For this purpose, airline business models were examined, and critical events in the organizational field were explored based on secondary data. The case study research was conducted to explore the link between the diversifications of the business model and institutional logic. The unit of analysis in this study is multiple cases, and gathered data were examined with the content analysis method. The results show that multiple institutional logics (state and commercial logic) in the field can pave the way or prevent diversifying airline business models. Multiple logics shape the regulations and approaches of the state and other organizations in the field, and these changes may play a role as a barrier or driver for diversification. Each barrier and driver may affect each airline's business model differently. This study contributes to business models and institutional logics literature by providing evidence of the effect of the pattern of approaches of the actors on the airline business models and by showing the relations between these approaches and institutional logic.
Entrenamiento técnico y biomecánico en Natación: El modelo del Centro de Alto Rendimiento de Sierra Nevada
Authors: De la Fuente Caynzos Blanca
Published: May 2023

Desde el comienzo de su actividad, La Unidad de Análisis del Rendimiento Deportivo (UARD) del C.A.R. de Sierra Nevada ha desarrollado protocolos de análisis técnico y de control del entrenamiento que han sido utilizados por nadadores y entrenadores durante sus estancias en el centro. Algunos de los trabajos realizados en este departamento, son: Test de 50 m + Viraje (Arellano, Pardillo & García, 1999), Desarrollo de bases de datos de errores técnicos para la corrección del nado, la salida o los virajes, Pruebas de análisis de la velocidad intraciclo, Análisis tridimensional de la fuerza y la trayectoria de la brazada, etc. La elección de uno u otro test se consensua con los entrenadores en función de la prontitud con la que requieran los resultados, eligiendo métodos que requieren procesamiento de los datos tras la realización de los test o bien sesiones de entrenamiento específico en las que existe aportación de feedback inmediato tras cada ensayo. En cualquier caso, se gestionan y entregan los resultados a través de bases de datos que permiten comparar la evolución de los nadadores a lo largo de sus estancias en el centro o bien comparar la ejecución con otros nadadores de la misma especialidad.
Evaluation of the Antibacterial Efficacy of Diclofenac as Intracanal Medicament Versus Triple Antibiotic Paste Against Enterococcus faecalis in Single Rooted Teeth (A Comparative In-Vitro Study)
Authors: Mohamed Esraa Amin , El-Asfouri Heba Ahmed , Bakry Shaimaa Ibrahim
Published: May 2023

Background: Elimination of intracanal microorganisms is essential for determination of the success of root canal therapy. This can be achieved through combination of mechanical preparation of the root canal along with disinfection with irrigants and intracanal medications. Resistant microorganisms create like E. faecalis an obstacle for achieving optimum disinfection.
Aim: The aim of this study is to evaluate the antimicrobial efficiency of diclofenac potassium paste in comparison to triple antibiotic paste against Enterococcus faecalis count developed in single rooted root canals by bacterial count determination.
Methods: Forty two human extracted single rooted teeth with single canals will be selected for this study. After chemomechanical preparation sample 1 will be collected. After that teeth will be inoculated with E. faecalis and sample 2 will be taken. Then the samples will be divided into 3 groups (n=14) each group for a tested medicament. Group 1 (triple antbiotic paste), group 2(diclofenac potassium paste), and group 3 (no medicament was applied). All teeth will be temporary sealed and left in an incubator for 7 days then sample 3 will be taken after medicament removal. Bacterial reduction count will be counted (CFU/ml) after cultivation in agar culture for all
3 samples.
Finite element and regression analysis for improving Terzaghi’s, Meyerhof’s, Hansen’s and Vesic’s bearing capacity methods
Authors: Pantelidis Lysandros
Published: May 2023

The bearing capacity of shallow foundations is one of the major fields in soil mechanics and foundation engineering. Since 1943, when Terzaghi suggested his famous equation with the three N-factors, several dozens of bearing capacity methods for centrically-vertically loaded strip footings have been proposed in the literature, mainly focusing on refining the Nγ factor. However, the methods proposed by Terzaghi, Meyerhof, Hansen and Vesic remain by far the most popular ones, with the last one to be component of many contemporary design codes. In this paper, the author put these four methods into extensive comparison against the finite element method. From the results it is clear that the scatter of values is a common characteristic, while none of these methods is superior to the others. During the last 100 years, Nγ was either a demon needing exorcise or a scapegoat. The regression analysis carried out by the author, however, clearly showed that it is not Nγ that prevents us from having a reliable analytical prediction for the bearing capacity of (strip) footings. Instead, all methods need a) to get rid of all original depth factors and b) calibration against the Df⁄B parameter (use of the same parameter for all three N-factors). The author applied both non-linear and linear regression analysis. Generally, the performance of all these methods was significantly improved after using a (const_1+ const_2∙Df⁄B) term as multiplier in front of the (untreated) bearing capacity formula and calibrating the constants against regression analysis and finite elements. Finally, the author offered corrected expressions for the four methods mentioned above, not only for the case of rigid footings but also for the case of flexible footings, as regression analysis was also carried out against the respective finite element results. In addition to the above it is mentioned that, in the calibration procedure against finite element analysis, the author considered the non-associated flow rule (ψ=0°). As known, an analysis with a non-associated flow rule is more representative of the actual soil behavior, while it is on the safe side.
Distinction between small RNA-bound and free ARGONAUTE via an N-terminal protein-protein interaction site
Authors: Bressendorff Simon , Sjøgaard Ida Marie , Prestel Andreas , Kragelund Birthe , Poulsen Christian , Brodersen Peter
Published: May 2023

ARGONAUTE (AGO) proteins bind to small non-coding RNAs to form RNA Induced Silencing Complexes (RISCs). In the RNA-bound state, AGO proteins are stable while RNA-free AGOs turn over rapidly. Molecular determinants unique to RNA-free AGO that allow its specific recognition and degradation remain unknown. Here, we show that a confined, linear region in Arabidopsis AGO1, the N-coil, is accessible to antibodies preferentially in the RNA-free state of AGO1. Reanalysis of hydrogen-deuterium exchange data on human Ago2 indicates similar structural flexibility of the N-coil depending on small RNA binding. Unloaded Arabidopsis AGO1 interacts with the autophagy cargo receptor ATI1 via direct contact to specific amino acid residues in the N-coil, and mutation of residues required for ATI1 interaction reduces the degradation rate of unloaded AGO1 in vivo. These results provide insight into the molecular basis for specific recognition and degradation of the RNA-free state of eukaryotic AGO proteins.
Microlensing sheds light on the detection of strong lensing gravitational waves
Authors: Shan Xikai , Chen Xuechun , Cai Rong-Gen , hu bin
Published: May 2023

The strong lensing gravitational wave (SLGW) is a promising transient phenomenon containing rich physics. However, due to the long-wave nature of gravitational waves (GW), poor sky localization makes identifying such events challenging. We propose a new method based on the wave optics effect of the microlensing field embedded in SLGW. The microlensing diffraction/interference fringes can produce frequency-dependent random fluctuations in the waveform. To pin down the microlensing-induced stochastic features in the waveform, we utilize both the template-independent method, cWB and the template-dependent method, Bilby, to reconstruct the waveform with and without microlensing imprints. The mismatching degree of these two waveforms can be treated as an indicator of SLGWs. We forecast the identification rate of this method with the third-generation GW observatory, such as Cosmic Explorer. Our result shows that this method can successfully identify about 2 (out of 180) SLGW events with strong enough microlensing effects per year. This method is entirely data-driven, immune to model priors, and can significantly avoid false positive errors formed by coincident unlensed events.
Building information extraction and earthquake damage prediction in an old urban area based on UAV oblique photogrammetry
Authors: Zhao Yu , Huang Bo , Zhu Zhizhong , Guo Jiachen , Jiang Jianqun
Published: May 2023

Seismic performance investigation and earthquake damage prediction of buildings in old urban areas are of great significance for the resistance to earthquake risks. Building properties are fundamental to the regional earthquake damage prediction. However, the properties of buildings in old urban may be insufficient and outdated. In this paper, the following researches are carried out to address the above problems: based on tilt photogrammetry, the properties including the spatial characteristics of footprint outline, number of storeys, footprint area, roof style and distribution density, etc. are extracted; The typical buildings in the old urban area are further distinguished with the direct spatial features of house, and the age of house is predicted by machine learning; The house model parameters are determined based on the extracted building properties that determine the seismic performance, and the floor shear model is used to carry out elasto-plastic time history analysis to complete the earthquake damage prediction.
Simplified treatment of children 6-59 months with severely low weight-for-age z-score: a study protocol for a 3-arm randomized controlled trial
Authors: Kangas Suvi T. , Ouédraogo Césaire T , Tounkara Moctar , Ouoluoguem Bareye , Coulibaly Issa Niamanto , Haidara Alhousseyni , Diarra Niele Hawa , Diassana Koniba , Tausanovitch Zachary , Ritz Christian , Wells Jonathan C , Briend André , Myatt Mark , Radin Elizabeth , Bailey Jeanette
Published: May 2023

Background
Admissions criteria which treat children with low mid-upper-arm circumference (MUAC), low weight-for-height z-score (WHZ) are not aligned with the evidence on which children are at risk of mortality. An analysis of community-based cohort data from Senegal found that a combination of weight-for-age (WAZ) and MUAC criteria identified all children at risk of near-term death associated with severe anthropometric deficits. This study will address whether children with WAZ<-3 but MUAC ≥ 125mm benefit from therapeutic feeding with ready-to-use therapeutic foods (RUTF) and whether a simplified protocol is non-inferior to the weight-based standard protocol.
Methods
This is a prospective individually randomized controlled 3-arm trial conducted in the Nara health district in Mali. Children aged 6–59 months presenting with MUAC ≥ 125 mm and WAZ <-3 will be randomized to: 1) control group receiving no treatment, 2) simplified treatment receiving 1 sachet of RUTF daily until WAZ ≥-3 for 2 visits, 3) standard treatment receiving RUTF according to WHZ category: a) WHZ<-3 receive 200 kcal/kg/d until WHZ ≥-2 for 2 visits, b) WHZ ≥-3 but <-2 receive 1 sachet daily until WHZ ≥-2 for 2 visits or c) WHZ ≥-2 receive no treatment. All children will be followed-up first fortnightly for 12 weeks and then monthly until 6 months post-enrolment. The primary endpoint will be measured at 2 months with the primary outcome being WAZ as continuous measure. Other outcomes include other anthropometric measurements and a secondary endpoint will be observed at 6 months. A total of 1397 children will be recruited including 209 in the control and 594 in both the simplified and standard arms. The sample size should enable us to conclude on the superiority of the simplified treatment compared to no treatment and on the non-inferiority of the simplified treatment versus standard treatment with a margin of non-inferiority of 0.2 WAZ.
Discussion
This trial aims to generate new evidence on the benefit of treating children with WAZ <-3 but MUAC ≥ 125 mm in order to guide the choice of admission criteria to malnutrition treatment and build evidence on the most efficient treatment protocol.
Trial registration
This trial was registered at clinicaltrials.gov: NCT05248516.
Theta-burst rTMS in schizophrenia to ameliorate negative and cognitive symptoms: study protocol for a double-blind, sham-controlled, randomized clinical trial
Authors: Gábor Csukly , Orbán-Szigeti Boglárka , Suri Karolin , Zsigmond Réka , Hermán Levente , Simon Viktória , Kabaji Anita , Bata Barnabás , Hársfalvi Péter , Vass Edit , Csibri Éva , Farkas Kinga , Réthelyi János
Published: May 2023

Background Treatment effects of conventional approaches with antipsychotics or psychosocial interventions are limited when it comes to reducing negative and cognitive symptoms in schizophrenia. While there is emerging clinical evidence that new, augmented protocols based on theta-burst stimulation can increase rTMS efficacy dramatically in depression, data on similar augmented therapies are limited in schizophrenia. The different patterns of network impairments in subjects may underlie that some but not all patients responded to given stimulation locations. Methods Therefore, we propose an augmented theta-burst stimulation protocol in schizophrenia by stimulating both locations connected to negative symptoms: (1) the left Dorsolateral Prefrontal Cortex (DLPFC), and (2) the vermis of the cerebellum. Ninety subjects with schizophrenia presenting negative symptoms and aging between 18–55 years will be randomized to active and sham stimulation in a 1:1 ratio. The TBS parameters we adopted follow the standard TBS protocols, with 3-pulse 50-Hz bursts given every 200 ms (at 5 Hz) and an intensity of 100% active motor threshold. We plan to deliver 1800 stimuli to the left DLPFC and 1800 stimuli to the vermis daily in two 9.5-minute blocks for four weeks. The primary endpoint is the change in negative symptom severity measured by the Positive and Negative Syndrome Scale (PANSS). Secondary efficacy endpoints are changes in cognitive flexibility, executive functioning, short-term memory, social cognition, and facial emotion recognition. The safety outcome is the number of serious adverse events. Discussion This is a double-blind, sham-controlled, randomized medical device study to assess the efficacy and safety of an augmented theta-burst rTMS treatment in schizophrenia. We hypothesize that social cognition and negative symptoms of patients on active therapy will improve significantly compared to patients on sham treatment. Trial registration The study protocol is registered at 'clinicaltrials.gov 'with the following ID: NCT05100888. All items from the World Health Organization Trial Registration Data Set are registered. Initial release: 10/19/2021.
Breeding practice of indigenous village chickens, and traits and breed preferences of smallholder farmers
Authors: Desta Takele Taye , Wakeyo Oli
Published: May 2023

In developing nations, indigenous village chickens, or IVCs, significantly contribute to rural livelihoods. IVCs are well-suited for small-scale farmers' multiple breeding objectives and low-input, low-output production systems. Although natural selection has a disproportionate impact on the genetic structure of IVCs, small-scale farmers have developed locally tailored breeding practices to get the most out of their flocks. Small-scale farmers' insights on traits and breed preferences and family flock breeding management are presented in this cross-sectional study. Small-scale farmers prefer IVCs that are optimally good in several traits. In contrast to policymakers, who frequently underestimate the significance of IVCs in rural life, small-scale farmers have a balanced view and acknowledge the coexistence of local and commercial chickens. Farmers are unable to achieve their breeding goals by keeping IVCs or production breeds because of the complexity of their breeding goals; instead, this aspiration needs the rearing of both types of chickens. Only 15.7 percent of farmers recruited homegrown cocks to breed their chickens, whereas 84.3 percent outsourced breeding cocks (47.9 percent from the local market and 36.4 percent from neighbors) (χ-squared = 15.976, df = 2, p = 0.0003395). This practice is important to reduce the negative impacts of inbreeding. About 49.2 percent of small-scale farmers believed that consanguineous mating-induced inbreeding had only minor effects. High flock turnover and uncontrolled breeding significantly reduce the rate of inbreeding. Despite the low production of eggs and meat, small-scale farmers prefer local (rank = 1.47) chickens to commercial (rank = 1.61). Farmers' preferences are influenced by the wide range of products and services offered by IVCs. For cocks, fertility, and growth traits were highly sought after, whereas for hens, maternal traits and laying performance were prioritized. Compared to the highlands, the lowlands had a longer egg storage period (t = 2.677, df = 117, p = 0.009, 95 percent CI: -3.7607, -0.5622). The low demand for eggs in the sparsely populated lowland region may be linked to this extended storage, which was practiced regardless of the higher temperature in the lowland region. This study acknowledges the wisdom of small-scale farmers and advocates the incorporation of their insights into a sustainable genetic improvement program.
Performance And Egg Quality Parameters Of Laying Chickens Fed Cassava (Manihot esculenta) Plant Meals Based Diets
Authors: Asaniyan Emmanuel Kehinde
Published: May 2023

The study was carried out to evaluate the effect of partial replacing maize with cassava plant meal on the performance and egg qualities of laying birds. One thousand (1,000) day old Isa Brown pullets were randomly assigned to four treatments of 10 replicates per treatment with each replicate comprising 25 laying pullets. The feeding trial lasted 12 months. The treatments were control (maize-based), cassava plant meal products (CPM 1, CPM2, CPM3). The CPMs were then used to constitute three experimental diets. The diets were 100% cassava-based on replacement of maize and a maize-based control diet. Result showed that CPM3 had a similar (P < 0.01) final weight and weight gain with the control diet (maize based) while CPM1 had the lowest and consumed the highest feed which result in a similar pattern for the FCR. Surprisingly, the highest mortality were recorded in birds fed CPM2 while the lowest (P < 0.0001) was recorded in CPM1 and CPM3. The control diet and CPM3 birds were the fastest birds to lay first egg while CPM 1 were the latest. Diet CPM 1 supported internal egg quality especially egg yolk colour while either CPM 2 or CPM 3 equally supported efficient egg production in terms of FCR/Kg egg mass as maize based diet without compromising the overall egg quality. Thus, CPM3 can successfully be used for partial replacement of maize during maize scarcity and high cost among farmers in developing countries.