bluuebunny/crossref_metadata_2025 huggingface dataset:
The association between serum ferritin levels and the risk of gestational diabetes mellitus：a prospective cohort study
Authors: Gao Shen , Su Shaofei , Zhang Enjie , Liu Jianhui , Xie Shuanghua , Zhang Yue , Liu Ruixia , Yue Wentao , Yin Chenghong
Published: July 2023

Background
The relationship of serum ferritin levels with the risk of gestational diabetes mellitus (GDM) remains unclear. The aim of this study is to investigate the association between serum ferritin levels and its change with the incident of GDM.
Methods
A prospective cohort study of 10,871 pregnancies from the China Birth Cohort Study were performed. Serum ferritin levels were measured by direct chemiluminescent method in the first and second trimester. Baseline serum ferritin were categorized into five groups by their quintiles in the first trimester. Serum ferritin changes were divided into four subgroups using the trimester-specific median as cut-off points. GDM was determined by a 75g oral glucose tolerance test at 24–28 weeks of gestation. Multivariate modified Poisson regressions were performed to estimate the independent relationship between serum ferritin levels and its change with the incident GDM.
Results
The median of serum ferritin levels in the first trimester was 57.7 ng/mL, and 13.5% of subjects developed GDM. After multivariate adjustment, the RRs and 95% CIs for incident GDM across baseline serum ferritin quintiles were 1.099 (0.940–1.285), 1.228 (1.055–1.430), 1.186 (1.018–1.383) and 1.179 (1.017–1.367), respectively. Furthermore, subjects with low serum ferritin levels in the first trimester but increased to high level in the second trimester (RR = 1.376,95%CI:1.169–1.612), as well as subjects with consistently high serum ferritin levels in the first and second trimester (RR = 1.351,95%CI:1.185–1.541) had a significantly increased risk of GDM.
Conclusions
Serum ferritin and its changes were independent risk factors of GDM. These findings underscore the importance of keeping iron metabolism at an appropriate level during early to middle pregnancy to reduce the risk of developing GDM.
Efficacy of Risk Messaging Styles on Health Behavior Intention during the COVID-19 Pandemic - Cross-Sectional Comparative Study
Authors: Harris Gaia , Bodas Moran
Published: July 2023

Background
The novel Coronavirus disease (COVID-19) pandemic started in late 2019. Various risk messaging styles were employed to promote public adherence to health guidelines. This study examines the effect of different risk messaging styles on public health intentions.
Methods
A cross-sectional interventional study used a representative sample (N=665) of adult Hebrew speakers in Israel. Participants were recruited through an online survey company and randomly assigned into five intervention groups representing different risk messaging styles and a control group. The study measured and compared health behavioral intention before and after watching the messages and measures of the Health Belief Model (HBM), trust in authorities, and personality traits.
Results
A slight but significant improvement in behavioral intention was observed after watching the broadcasts (+0.06 points on a scale of 1-5), mainly attributed to two of the intervention groups (+0.10 and +0.13 points). The change in behavioral intention was positively correlated with cues to action and self-efficacy. A positive correlation was found between the level of trust in authorities and change in behavioral intention (rs=0.132, P <0.001). After watching all broadcasts, the feelings tended to be either neutral or slightly positive (range: 3.45 to 4.80 on a six-point scale), and not a single broadcast evoked negative feelings exclusively. However, there was no correlation between evoked feelings and change in behavioral intention at the sample level. In a simple linear regression for predicting change in behavioral intention, which included the two most perceived negative and positive broadcasts, there was a trend toward an association between positive feelings and behavioral intention (p=0.055).
Conclusions
The findings may support the argument that risk messaging that evokes positive feelings, compared with negative (e.g., frightening) feelings, have a higher potential to achieve behavioral intention. It is recommended to promote future public health behavior during pandemics using messages that evoke positive feelings, strengthening their sense of self-efficacy in implementing the recommended actions and presenting the information about the optimal behavior in a clear, consistent, and reliable manner. In addition, disaster managers ought to aspire for more public trust in authorities to foster more meaningful change in attitudes toward health regulations.
Fabrication and Electrical Characterization of a Transistor Device Configuration Based on Graphene Oxide Films
Authors: Marin D. S. , Franco-Osorio H. , Prías-Barragán J. J
Published: July 2023

The films of graphene oxide multilayer synthesized from bamboo as material source (GO), by the method of double thermal decomposition (DTD-method), for carbonization temperatures of 973 and 1023 K, exhibited electrical behavior as semiconductor with narrow band-gap energy and conduction mechanism by the Mott 3D variable range hopping, postulating this material as an excellent candidate for the development of electronic devices. This work presents the fabrication procedure and electrical characterization of a transistor configuration based on GO films (GOT). The electrical characterization was carried out in an automated system at low power and it were measured the transistor curves families of input, output, reaction and transfer in GOT devices. The results obtained suggest that GOT devices could be used in switching and voltage attenuation applications in low electrical power circuits, given the electrical behavior obtained as voltage dependent voltage sources with unitary gain approximately.
WITHDRAWN: Elevated glucose promotes DNA replication and cancer cell growth through pRB-E2F1
Authors: Liu Xuan , Zhou Qi , Bai Dongmei , Schrier Jacob
Published: July 2023

Although epidemiological studies have highlighted a link between hyperglycemia and increased risk of cancer, knowledge about the molecular mechanism behind the link is still limited. In this study, we report that high glucose levels (HG) enhance DNA replication, leading to tumor cell growth. Moreover, through genome-wide analyses, we identify E2F1 as the core transcription factor for this HG-induced cell adaptation. Inhibition of E2F1 abrogates the HG-induced DNA synthesis and cell growth, supporting the role of E2F1 in this process. Furthermore, we demonstrate that elevated glucose levels enhance pRB phosphorylation, which plays a role in E2F1 activation. Interestingly, among HG-induced E2F1 target genes, RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) participates in the nucleotide synthesis by catalyzing the generation of the essential dNTP for DNA replication. We show that HG increases cellular dNTP levels in E2F1-RRM2-dependent manner, which correlates to enhanced DNA synthesis and cancer cell growth. Collectively, our findings decipher a pRB-E2F1-RRM2 dependent link between hyperglycemia and cancer cell proliferation and provide a molecular mechanism by which hyperglycemia directs tumor cells to DNA replication.
Exploring the Socio-Technical Imaginary of Artificial General Intelligence in The Bard Large Language Model: A Narrative Analysis on Perspectives and Dialectics
Authors: Bojic Ljubisa , Davidovic Jovan
Published: July 2023

The launch of ChatGPT, a large language model, in November 2022 has generated significant interest and rapid adoption, amassing 1 million users within its first five days and reaching 100 million users in just two months. This has ignited widespread public discussion and debate on the implications of artificial intelligence, drawing attention to the more advanced and controversial concept of Artificial General Intelligence (AGI) exhibiting a broad range of cognitive abilities, such as learning, reasoning, problem-solving, and adapting to new and unfamiliar situations, with potential applications across various fields in society, including healthcare, transportation, and environmental management. This study investigates the presence of a socio-technical imaginary surrounding AGI in the discourse of the Bard large language model through an in-depth interview. Using narrative analysis, we identified dialectics of optimism, pessimism, epochalism, and inevitability in an interview with Bard. Our findings reveal a greater inclination towards optimism (73 segments, 4182 words) than pessimism (56 segments, 3774 words), along with the presence of both inevitability (40 segments, 1458 words) and epochalism (31 segments, 1161 words). These results suggest that Bard reflects the diverse perspectives, beliefs, biases, and narratives on AGI present in the data it was trained on. Optimistic perspectives were identified concerning the potential impact of AGI on numerous aspects of human life, such as education, arts and culture, creativity, relationships, family, economy, governance, environment, and the exploration of the universe. Conversely, pessimistic viewpoints were observed in relation to AGI's potential effects on creativity, relationships, family, unemployment, political stability, interstate conflict, the development of superhumans, media manipulation, intelligence explosion, simulated reality, and a dystopian future. Additionally, a comprehensive examination was conducted on four major themes derived from a qualitative analysis of the interview with Bard. These themes, which include the relationship between humans and AGI, the notion of AGI acquiring a physical body, AGI simulating a universe, and the responsible use of AGI for good, provide valuable insights into the socio-technical imaginary encompassing AGI. The identified concepts have been recognized in existing literature, further illustrating that the socio-technical imaginary surrounding AGI is captured by the LLM. However, the study is limited by the scope of the interview and the organic responses generated by Bard during its testing phase. Further research could explore how the model's representation of AGI discourse may change with additional training and fine-tuning, potentially impacting its utility for understanding the socio-technical imaginary around AGI.
Determination of serum zinc and phosphorus levels in patients with hypothyroidism
Authors: Patel Amrendra Mani , Khan Saba , Inam Ahmad Merajul Hasan , Alam Roshan , Khan Mohammad Mustufa
Published: July 2023

Background Various studies reported that serum zinc (Zn) and phosphorus (P) levels altered in patients with hypothyroidism and vice versa, but results were found inconsistent. Aim It was aimed to find the association between serum Zn and P in patients with hypothyroidism.Material andMethod In this case-control study, a total of 100 subjects (50 newly diagnosed patients of hypothyroidism and 50 controls) were enrolled aged between 25 and 60 years. Biochemical parameters such as thyroid profile, serum Zn, and P were estimated in each subject. A p < 0.05 was considered statistically significant. Result The mean level of body mass index (BMI), thyroid-stimulating hormone (TSH), and serum P was found significantly elevated in cases compared to controls (p < 0.001). However, the mean level of triiodothyronine (T3), thyroxine (T4), and serum Zn was found significantly reduced in cases compared to controls (p < 0.001). The serum Zn has shown a significant negative correlation with T3 and BMI among cases (r= -0.313 p < 0.05, r= -0.338 p < 0.05, respectively). However, Serum P has shown a significant positive correlation with TSH and BMI among cases (r = 0.310 p < 0.05, r = 0.449 p < 0.01, respectively). Regression analysis indicated that serum Zn significantly predicted hypothyroidism (p < 0.00). Similarly, Serum P significantly predicted hypothyroidism (p < 0.007). Conclusion Results showed that serum Zn levels were significantly reduced and serum P levels were significantly elevated in cases compared to controls. The serum Zn and serum P both may act as predictors for hypothyroidism and its complications.
Genetic diversity and population structure of Mastacembelus armatus in the river systems of southern China revealed by microsatellites
Authors: Lin Tingting , Yang Jinlin , Yu Zhide , Feng Yuwei , Qin WeiJian , Lu Baoyue , Cui Mingxiang , Han Chong , Shu Hu
Published: July 2023

Background The Zig-zag eel (Mastacembelus armatus) is an economically important species in southern China. Its natural resources have declined year by year due to overfishing. Understanding its genetic diversity and population structure is very important for resource conservations.Objective We aimed to develop highly polymorphic microsatellites and further use them to complete the genetic diversity and population structure analysis of M. armatus in southern China.Method A total of 188 individuals of M. armatus were collected from 7 locations in different river systems in south China and further used to performed genetic diversity and population structure analysis based on polymorphic microsatellites.Resuls Here, we first successfully developed 28 polymorphic microsatellite markers for zig-zag eels and ten of them were used to examine the genetic diversity and differentiation of 7 populations collected from the major river systems of south China. In total, 224 alleles were found with the 10 microsatellite loci in 7 populations, ranging from 4.6 (NDJ) to 11.1 (XJ), with an average of 8.871 alleles. The average observed and expected heterozygosity ranged from 0.550 (NDJ) to 0.964 (YJ) and from 0.537 (NDJ) to 0.775 (TJ), respectively. The average polymorphism-information content ranged from 0.472 (NDJ) to 0.757 (TJ). Hardy-Weinberg equilibrium test results revealed the loci showed differing deviation in different populations. In total, low level of genetic diversity was only found in HJ and NDJ populations. Besides, evidence of recent bottleneck was found in the HJ populations. Analysis of molecular variation showed that the percent variation within individuals (75.00%) was higher than that among populations (25%). In addition, population structure and the pairwise FST revealed that there was low differentiation among XJ, TJ and YJ populations.Conclusions These data provide important genetic resources for understanding the population differentiation and facilitating genetic conservation and utilization of this species.
Robust optimal control of a nonlinear surface vessel model with parametric uncertainties
Authors:   Department of Mechatronics Engineering, Istanbul Technical University, Jambak Ahmad Irham , Bayezit Ismail
Published: July 2023

This paper presents a fast alternative optimization method for developing a reliable optimal controller that can handle system model parameter uncertainties. The source of uncertainty in this study is identified as hydrodynamic coefficients, which are prone to errors due to the challenges involved in obtaining accurate values. The proposed optimization method utilizes a complex nonlinear ship model provided by Maneuver Modelling Group (MMG) as the reference for the ship motion model. The optimization process is divided into two stages: a blind search followed by bisection optimization, to obtain a robust optimal controller. To demonstrate the effectiveness of the proposed approach, system response analysis and practical tests were performed on Step, M-Turn, and Doublet maneuvers. The results show that the controller parameters obtained from the proposed optimization method are capable of achieving high success rates in controlling a system with uncertain parameters.
Analysis of methods for monitoring the technical condition of high-voltage electronic measuring transformers
Authors: Litvinov S. N. , Lebedev V. D. , Gusenkov A. V.
Published: July 2023

The objectives of the present study included an analysis of statistical data on the failure causes of highvoltage equipment with a particular focus on current and voltage measuring transformers; a study of factors affecting the technical and functional condition of measuring transformers; a review of available methods for monitoring the technical condition of high-voltage electronic measuring transformers; the development of the basic principles of a stationary system for monitoring the technical capabilities of electronic measuring transformers. A review of available scientific publications and copyright objects on the aforementioned problems was conducted. The results were processed using the principles of systematic approach, as well as induction, deduction, classification and abstraction methods. The existing methods for monitoring the technical condition of high-voltage electronic measuring transformers were analyzed. The influence of various regimes and external factors on the technical and functional state of measuring transformers was investigated. The main principles for developing a stationary system for monitoring the technical condition of electronic measuring transformers were formulated. It was established that the failure of measuring transformers in medium voltage networks accounts for 6% of all failures. In 110 kV and higher-voltage networks, this level reaches 7%. It was found that the majority of accidents is associated with damaged insulation, poor-quality manufacturing and installation of the equipment, the impact of operating parameters and external factors on the technical and functional state of measuring transformers. Based on the considered methods for monitoring the technical condition of high-voltage equipment, a functional scheme of a stationary system for monitoring the technical capabilities of electronic measuring transformers at a digital substation is proposed.
A review of international experience in forecasting renewable energy generation using machine learning methods
Authors: Sergeev N. N. , Matrenin P. V.
Published: July 2023

In this work, we conduct an analytical review of contemporary international approaches to forecasting the volume of electricity generated by renewable energy sources, as well as to investigate current problems and prospective solutions in this field. The existing forecasting methods were classified following an analysis of published literature on the development of forecasting models, including those based on physical, statistical and machine learning principles. The application practice of these methods was investigated to determine the advantages and disadvantages of each method. In the majority of cases, particularly when carrying out short-term forecasting of renewable electricity generation, machine learning methods outperform physical and statistical methods. An analysis of the current problems in the field of weather data collection systems allowed the major obstacles to a wide application of machine learning algorithms to be determined, which comprise incompleteness and uncertainty of input data, as well as the high computational complexity of such algorithms. An increased efficiency of machine learning models in the task of forecasting renewable energy generation can be achieved using data preprocessing methods, such as normalization, anomaly detection, missing value recovery, augmentation, clustering and correlation analysis. The need to develop data preprocessing methods aimed at optimizing and improving the overall efficiency of machine learning models for forecasting renewable energy generation was justified. Research in this direction, while taking into account the above problems, is highly relevant for the imp lementation of programs for the integration of renewable energy sources into power systems and the development of carbon-free energy.
Feasibility of using phase-shifting transformers to increase the throughput of interconnected power transmission systems
Authors: Shoiko V. P. , Butakova A. M.
Published: July 2023

This paper discusses measures aimed at improving the efficiency of power systems by increasing the capacity of power transmission lines. To that end, a FACTS technology based on a phase-shifting transformer was used. The feasibility of using phase-shifting transformers to increase the throughput capacity of interconnected power transmission systems was investigated by determining the maximum allowable cross-section flows of the United Energy System of the Urals – the United Energy System of Siberia. The studied cross-section included 500 kV transmission lines and the extended 220 kV Nizhnevartovskaya GRES – Tomskaya transit. Calculations were performed for normal and various post-emergency schemes using the RastrWin3 software package. The regulation of phas e-shifting transformer branches and the direction of power flow in the section were taken into account. For the considered cross -section, the use of a phase-shifting transformer was shown to provide for the 220 kV transit operation in a closed mode. This i mproved the reliability of power supply in the region and allowed the maximum allowable overflow to be increased by 35 – 71%. In addition, similar calculations were carried out for the option of strengthening the 220 kV transit through the construction of a parallel 500 kV line. The effect of increasing the capacity of this option was established to reach 20 –35%. The decisive factor limiting the maximum permissible cross-section flows during 220 kV transit short circuit in the normal and reinforced versions was found to be the current overload of the head sections. Recommendations on the preferable use of an open transit mode are formulated. In conclusion, the efficiency of power systems can be improved by increasing the transmission capacity of power lines through the use of phase-shifting transformers. A segment of the Unified National Power Grid of Russia, where such devices are technologically expedient, was identified.
Improving the quality of metallurgical-grade silicon by acid leaching
Authors: Nemchinova N. V. , Zaitseva A. A.
Published: July 2023

This work deals with the problem of hydrometallurgical refining of metallurgical-grade silicon. Samples of metallurgical-grade silicon after oxidative refining from JSC Silicon, RUSAL (Shelekhov, Irkutsk Oblast, Russia) were subjected to X-ray fluorescence and electron microprobe analysis. The conducted elemental analysis determined their following composition, wt%: Al – 0.53, Fe – 0.6094, Ti – 0.0491, Ca – 0.0628, V – 0.0066, Cr – 0.002, Mn – 0.014, Cu – 0.003, P – 0.010, Ba – 0.007, Ni – 0.007, and Zn – 0.002. The examined samples were found to comprise the following intermetallic compounds: AlFeSi2 (with an admixture of Ca), FeSi2 (with an admixture of Al), and FeSi2Ti (with an admixture of Zr). In order to purify silicon from impurities, 10% H2SO2, HCl, HNO3, as well as 4% HF in different ratios were used as solvents. The feasibility of interactions between the intermetallic compounds and the selected solvents was assessed by calculating changes in the Gibbs energy, which had negative values. Experiments on impurity leaching were carried out using silicon samples with a particle size of –200 µm under constant stirring with a magnetic stirrer under the temperature of 600С, the liquid-to-solid ratio of 5:1, and the leaching duration of 60 min. The highest degree of silicon purification (86.85%) was achieved under leaching with a mixture of sulfuric and hydrofluoric acids in a ratio of 1:1. The use of a mixture of sulfuric and hydrochloric acids at a ratio of 1:3 resulted in the silicon purification of 41.48%. Thus, optimal solvents allowing the maximum purification of silicon from impurities were determined.
The influence of heat treatment type on the fat component and heterocyclic aromatic amines formation in minced poultry meat products
Authors: Aslanova M. A. , Derevitskaya O. K. , Dydykin A. S. , Bero A. L. , Soldatova N. E.
Published: July 2023

In this study the influence of heat treatment type on the change in the fatty acid composition, indices and parameters of fat oxidation, the level of heterocyclic amines formation in the chopped poultry ready-to-eat products enriched with ω‑3 fatty acids and an antioxidant complex were studied. The composition of ingredients and recipes of ready-to-eat products are developed with consideration of the medical and biological requirements for the diets of oncological patients. These ready-to-eat products feature some antioxidant substances in their composition that can bind free radicals, and provide for a reduction in the risk of carcinogens formation during the manufacturing process. The heat treatment was run in several ways, also called as modes — cooking in a microwave oven (MW), cooking in a convection oven in the “convection” mode with preliminary short-term roasting, steam cooking. For comparison, the conventional, i. e. not enriched food sample was used as a control one. The introduction of ω‑3 fatty acids into the food formulation made it possible to change the fatty acid composition towards increasing the proportion of polyunsaturated fatty acids (PUFAs). It was found that the profile of fatty acids was influenced by both the ingredients of the product and the type of its heat treatment. The joint use of a PUFA source and a complex of antioxidants made it possible to obtain a ready-to-eat product with a high level of ω‑3; and to ensure the ratio of ω‑6 group acids: ω‑3 ratio amounts to 1–2:1. Heat treatment of enriched semi-finished products by microwave cooking and by steam cooking showed a lesser effect on the change in the content and composition of polyunsaturated fatty acids — the loss of fatty acids was 1.2% and 2.8%, respectively, while in the “convection” cooking mode with preliminary roasting this loss was equal to 3.5%. It was found that the antioxidant complex in the composition of the food product and gentle heat treatment methods cause less lipid peroxidation and the formation of carcinogenic heterocyclic aromatic amines (HAA) during the food manufacturing process.
PERCEPTIONS, MANAGEMENT METHODS AND CONFLICTS ASSOCIATED WITH SOCIAL CASH TRANSFERS IN RURAL NIGER
Authors:   Departement de Geographie, Ecole Normale Superieure, Universite Abdou Moumouni, BP 10963, Niamey, Niger., Bagna Amadou Abdou
Published: July 2023

Following the example of other African countries, Niger has also set up a social safety net system based on two major programmes: the cash transfer programme and the cash-for-work programme implemented by a project which now constitutes a permanent institutional mechanism of the State. The aim of this system is to strengthen the resilience of poor people suffering from food and nutritional insecurity by regularly transferring them a minimum amount of financialresources. This study focuses on the first programme, cash transfers. It examines the strategies used by beneficiaries to control and manage cash by analysing the perceptions of key players regarding the principles of the intervention. The results show a diversity of ways in which cash is managed and used, which largely reflects the socio-demographic characteristics of the beneficiaries. In addition, the study reveals a number of problems surrounding this cash intervention, which has now become a real dilemma for certain players in the face of the populations lack of understanding.
ANALYSIS OF SYEIKH JUNID THALAS THOUGHTS IN THE FIELD OF ECONOMICS: THE FATHER OF EDUCATIONAL WAQF DEVELOPMENT IN THE ARCHIPELAGO
Authors:   Akademi Pengajian Islam Kontemporari (ACIS), Universiti Teknologi MARA, Shah Alam., Asmadi Yakob Mohd , Hapiz Mahayadin Mohd ,   Akademi Pengajian Islam Kontemporari (ACIS), Universiti Teknologi MARA, Shah Alam., Afandi Mat Rani Mohd ,   Akademi Pengajian Islam Kontemporari (ACIS), Universiti Teknologi MARA, Shah Alam., Fadylawaty Binti Syed Abdullah Sharifah ,   Akademi Pengajian Islam Kontemporari (ACIS), Universiti Teknologi MARA, Shah Alam., Noer Rahmi Asri ,   Universitas Al-Azhar Indonesia. Jakarta.
Published: July 2023

This paper focuses on the study of the thinking of the development of education endowment in the writings of Sheikh Junid Thala, a scholar of the archipelago. This study refers to the Book of Kaifiat, which holds the waqf of Muslims. Apart from writing about waqf, Sheikh Junid also applied the waqfsystem in his studies when he established several schools at that time. Due to the great contribution to the field of waqf, the objective of this study is to look at the leading ideas, thoughts and contributions of Sheikh Junid Thala in developing educational endowments. This is a qualitative studyusing the methodology of text, making reference to books and writings about Sheikh Junid, and the writing of contemporary educational endowment. The study found that Sheikh Junid Thala is a pioneer in the expansion of educational endowment in the archipelago. His writing and thinking related to the endowment of education will be an important reference for developing the endowment of nowadays education. Overall, the discussion of 100 methods of developing waqfassets written by Sheikh Junayd Thala is very interesting to be explored in the context of contemporary waqfimplementation. The economic thinking of Sheikh Junayd Thala, asa waqf development figure of the archipelago is considered updated and qualifies him to be named as the Father of the Development of Waqf Pendidikan Nusantara.
IMPLEMENTATION OF IOT BASED PATIENT HEALTH MONITORING SYSTEM USING ESP32 WEB SERVER
Authors: Ferdous Jannatun , Roy Boyidhanath , Hossen Motalab , Mehedi Islam Md.
Published: July 2023

The focus of this project is to implement an intelligent health care system based on internet of things (IOT) for the measurement of the vital signs like pulse rate, temperature, spo2, using (ESP32 div kit) for wireless wearable sensor controller and ESP32 server. With the system proposed, the doctor can save work time to visit the patients that responsible about them and any facilitates monitoring the huge number of patients. The WI-FI technology is utilized as a communication tool to allow transmission the data remotely. The data of patient are sent to the web server to be stored in the database and view the data on the web page anywhere and anytime using smart devices and alert the doctor to any abnormal state. This work with the intelligent health care system provide an efficient medical service, by collecting and recording the information that include heart rate, temperature and spo2 that enable the doctor to monitor this patient with flexibility and confidence. Also, we highlight the challenges in the implementation of IoT health monitoring system in real world.
CRYPTOCOCCAL INFECTION IN PLHIV : SERIES OF 12 CASES AT THE LABORATORY OF MOHAMMED VI UNIVERSITY HOSPITAL OF MARRAKECH
Authors:   Biology Department, Parasitology-Mycology Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech., El Hakkouni Awatif , Soraa Nabila ,   Biology Department, Microbiology Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech., Amrani Asma ,   Biology Department, Microbiology Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech., Tassi Nora ,   Medicine Department, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech., Mezouari Mostafa ,   Biology Department, Parasitology-Mycology Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech., Moutaj Redouane ,   Biology Department, Parasitology-Mycology Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech.
Published: July 2023

Background: Cryptococcal infection is opportunistic and causes high morbidity and mortality among severely immunocompromised patients, specially those living with HIV/AIDS (PLHIV). Cryptococcus neoformans is the most frequently identified species, incriminated in 90% of cryptococcal meningitis (CM). Methods: This is a descriptive retrospective study over a 2-years period (2021 - 2022) involving 12 PLHIV in whom we have isolated Cryptococcus neoformans from cerebrospinal fluid (CSF), blood culture, respiratory or skin specimen. All patients received antifungal therapy, associated to therapeutic lumbar punctures for those who presented with increased intracranial pressure. The clinical examination findings, laboratory data and evolution under treatment of these patients were reviewed. Results: The twelve patients were all HIV-infected adults, with median age of 41.25 Â± 12.22 years and male predominance with a sex ratio of 1:2. All patients had low CD4 T-cell counts at diagnosis (<100 cells/Âµl). Neurological involvement existed in all patients of this cohort : Isolated CM was diagnosed in three cases (25%). Nine patients (75%) had disseminated cryptococcosis: Central nervous system (CNS) with positive hemoculture in six cases, CNS and pulmonary involvement with positive hemoculture in two cases, CNS and cutaneous involvement with positive hemoculture in one case. Cryptococcus neoformans was identified in all cases. Of the twelve patients, seven (58%) survived with good response to the treatment. Lethality rate was 42%. Conclusion: This study demonstrates cryptococcal disease is a high mortality infection in PLHIV.Priority should be given to access to rapid diagnostic CrAgtests to accessibility to liposomal amphotericin B. This could improve the clinical outcome of the patients in our moroccan context.
CHARACTERISTICS OF GROUND WATER QUALITY AND DRINKING WATER QUALITY INDEX: A CASE STUDY OF CUDDALORE DISTRICT
Authors:   PhD Research Scholar Department of Geography Queen Marys College Chennai ., Jayanthi M. , Geetha G. ,   Assistant Professor & Head of Department of Geography Queen Marys College Chennai.
Published: July 2023

The water and environment has become an emotive issue with the people and policy makers. The chief causes for the pollution of water and environment are anthropogenic activities of human beings. The primary objective of this paper is to study the groundwater quality parameters in the wells of Cuddalore district in Tamil Nadu. The data is collected from the study area for two years i.e., 2002 and 2022. The groundwater contour analysis is done by using Geographical Information System (GIS). The water quality index has calculated based on Total Dissolved Substances (TDS), Nitrate (NO3), Calcium (Ca), Magnesium (Mg), Chloride (Cl), Sulphate (SO4), Fluoride (F), Power of Hydrogen (pH) and Electrical Conductivity (EC) The study reveals that the concentration of major constituents is well within the permissible limits of Indian Standard, except in few cases where Electrical Conductivity, Chlorine and Sulphates concentrations are high. The overall ground water index reveals that the water quality in Cuddalore district has increased considerably from the year 2002 to 2022. Spatially, unsuitable area has increased from the year 2002 to 2022 similarly excellent suitability of drinking water is also increased during the same period. Hence, from the assessment it is recommended to take necessary steps to improve further for the protection of environment and human beings.
Promoting digital employment intention among students of Chinese higher education institutions
Authors: Yu Jinshen , Jiang Songyu , Han Jian , Li Lin , Ke Xiaojun
Published: July 2023

Digital employment is one of the critical concepts of the digital economy for sustainable development. Promoting digital employment intention of potential employees is indispensable for developing the digital economy. The study aims to explore how digital employment policies predict digital employment intentions and to construct a structural equation model. Based on an online survey of 470 students with digital work experience from Chinese higher education institutions, the data were processed using SPSS 26.0 and Amos 26.0. The results uncover that digital employment policies have a positive impact on digital employability (β = 0.538, p < 0.001), digital employment capital (β = 0.524, p < 0.001), and digital employment intentions (β = 0.257, p < 0.001). At the same time, digital employability (β = 0.216, p < 0.001) and digital employment capital (β = 0.505, p < 0.001) also have a positive impact on digital employment intentions. The structural equation model emphasizes the significant mediating effect of digital employability (0.116) and digital employment capital (0.265). Therefore, the government should actively promote digital policies to encourage and enhance digital employment capabilities, promoting digital employment intentions and behaviors. The support and development of digital employability by the entire society, especially schools, and families, is also significant.
Trials on ciprofloxacin removal from wastewater using a photocatalytic membrane reactor
Authors:   National Research and Development Institute for Industrial Ecology, Constantin Mirela Alina , Chiriac Florentina Laura ,   National Research and Development Institute for Industrial Ecology, Ionescu Ioana Alexandra ,   National Research and Development Institute for Industrial Ecology, Constantin Lucian Alexandru ,   National Research and Development Institute for Industrial Ecology
Published: July 2023

Trials on ciprofloxacin removal from real aqueous systems were performed using a photocatalytic membrane reactor with catalyst in suspension. Four sets of four treatment cycles were carried out and experimental results were processed from the statistical point of view in order to assess results reproducibility. Global ciprofloxacin removal efficiencies of more than 99.85% were obtained for all treatment cycles. Coupling of photocatalytic degradation with membrane process allowed catalyst separation and reuse within further treatment cycles. Statistical analyse of experimental data recommends the use of photocatalytic membrane reactors as a feasible option for the advanced removal of pharmaceutical products like ciprofloxacin from real wastewater systems.
Environmental assessment of wastewater from food and beverage production in the Romanian urban water cycle
Authors:   National Research and Development Institute for Industrial Ecology, Petre Valentina Andreea , Vasilache Nicoleta ,   Environmental assessment of wastewater from food and beverage production in the Romanian urban water cycle, Tenea Anda-Gabriela ,   National Research and Development Institute for Industrial Ecology, Paun Iuliana ,   National Research and Development Institute for Industrial Ecology, Vasile Gabriela-Geanina ,   National Research and Development Institute for Industrial Ecology, Rudaru Daniel ,   National Research and Development Institute for Industrial Ecology, Chiriac Florentina Laura ,   National Research and Development Institute for Industrial Ecology
Published: July 2023

The food and beverage industries are considered essential sources of wastewater contaminated with pollutants discharged into the sewerage networks of cities. This study focused on monitoring the analytical parameters regulated in the environmental legislation in force in Romania for factories with various sectors of activity in the processing industry. The main objective is to understand the presence of conventional contaminants in the effluents from the food and alcoholic beverages industry and raise awareness of the effects of spillage in local networks. The study occurred over three years, between 2020 and 2022 when monthly wastewater samples from factories processing chocolate, meat, and alcohol were monitored. Values that exceed the maximum allowed limits were recorded for the meat processing factory due to the processed raw materials. The effluents resulting from the technological processes of meat processing significantly impact the aquatic environment.
A Review of Drug-related Associations Prediction Based on Artificial
Intelligence Methods
Authors: Ma Mei , Lei Xiujuan , Zhang Yuchen
Published: July 2023

Background:

Predicting drug-related associations is an important task in drug development
and discovery. With the rapid advancement of high-throughput technologies and various biological and
medical data, artificial intelligence (AI), especially progress in machine learning (ML) and deep learning
(DL), has paved a new way for the development of drug-related associations prediction. Many studies
have been conducted in the literature to predict drug-related associations. This study looks at various
computational methods used for drug-related associations prediction with the hope of getting a better
insight into the computational methods used.

Methods:

The various computational methods involved in drug-related associations prediction have
been reviewed in this work. We have first summarized the drug, target, and disease-related mainstream
public datasets. Then, we have discussed existing drug similarity, target similarity, and integrated similarity
measurement approaches and grouped them according to their suitability. We have then comprehensively
investigated drug-related associations and introduced relevant computational methods. Finally,
we have briefly discussed the challenges involved in predicting drug-related associations.

Result:

We discovered that quite a few studies have used implemented ML and DL approaches for
drug-related associations prediction. The key challenges were well noted in constructing datasets with
reasonable negative samples, extracting rich features, and developing powerful prediction models or ensemble
strategies.

Conclusion:

This review presents useful knowledge and future challenges on the subject matter with the
hope of promoting further studies on predicting drug-related associations.
Crown in Pediatric Dentistry
Authors: Patil Anil , Nikam Prathamesh P. , Sakhare Dhanashree
Published: July 2023

The basis for safe permanent teeth in infants and teens is laid during the first years of childhood. Several studies have linked dental caries in children to insufficient diet, unhealthy eating habits, and insufficient toothbrushing habits during the first two years of childhood. The emergence of caries in primary teeth increases the chance of developing caries in permanent teeth. Once a tooth has decayed in young children, the paediatric dentist plays a crucial role to return the tooth to its full functioning potential. The technical advancements in dental products utilized in children over the last few decades are a necessary prerequisite because what was acceptable in the past is not necessarily the safest way to treat young patients nowadays. Several alternatives exist to restore carious teeth in paediatric patients, ranging from stainless steel crowns to aesthetic crowns such as strip crowns and zirconium crowns, which are gaining popularity. This chapter contains a description of the crowns in paediatric dentistry.
Topical Application of Fluorides
Authors: Goswami Mousumi , Jain Palak
Published: July 2023

Fluoride is present in natural water sources and occurs as an ionic form of fluorine trace element. It is a safe and effective agent used primarily to prevent dental caries, especially in children. Fluoride can remineralize calcium hydroxyapatite crystals in enamel by forming acid-resistant calcium fluorapatite crystals. It can be administered topically as well as systemically. Topical fluorides form a vital part of preventive oral health programs and help promote enamel remineralization, inhibit bacterial metabolism, and reduce the growth of bacteria in plaque. Various methods for delivering topical fluorides include self-applied toothpaste, gels, mouthwashes, professionally applied varnishes, and other gel forms. This chapter provides an overview of the different topically applied fluoride agents, their mechanism of action and the recommendations for their use in children.
DIP - Desafio de Identificação de Personagens: objectivo, organização, recursos e resultados
Authors: Santos Diana , Mota Cristina , Pires Emanoel , Langfeldt Marcia , Schumacher Fuão Rebeca , Willrich Roberto
Published: July 2023

Este artigo apresenta o Desafio de Identificação de Personagens (DIP) em profundidade. Documenta a sua motivação, as escolhas feitas, o desenrolar do processo de organização, a avaliação conjunta, e os resultados que podemos mostrar, assim como os recursos compilados e que são públicos. Relatamos o que aprendemos com a organização do DIP e o que aprendemos sobre a literatura em português. Por exemplo, nas obras do DIP, (1) o número de personagens femininas é muito inferior ao das personagens masculinas, (2) existem sempre algumas personagens referidas com nomes diferentes na mesma obra, (3) a profissão mais mencionada é a de padre, (4) há mais referência a pais do que a mães, e (5) os diminutivos são bastante frequentes.
A Panorama of Linguistic Landscape Studies
Authors: Gorter Durk , Cenoz Jasone
Published: July 2023

This book provides an overview of how the field of Linguistic Landscape Studies has emerged and developed over the past 20 years, combined with an in-depth exploration of the theoretical approaches, innovative research methods and major themes that have been central to this dynamic area of research.
Association between hemoglobin level and food consumption among female nursing students at King Faisal University, Saudi Arabia
Authors: Abdelrahem Aml Sayed , Alomar Norah , Kumari Sheeba , Albokhamseen Shima I. , Alduhailan Mariam M. , Mousa Ola
Published: July 2023

Anemia exerts significant adverse impacts on health and the economy, both in developing and developed nations across the globe. The physiological and physical changes that transpire during adolescence and early adulthood necessitate heightened nutritional requirements. Among teenagers and young adults, anemia manifests as a frequent condition. The objective of our study was to determine the prevalence of anemia and its contributing factors among female nursing students enrolled at King Faisal University in Al Hasa, located in the Eastern Region of Saudi Arabia. Employing a cross-sectional design, we conducted an investigation involving a cohort of 83 nursing students who were in good health. To ensure adherence to COVID-19 safety protocols, we employed a practical sampling method to collect the samples. Hemoglobin (Hb) levels were assessed using a finger-stick capillary blood sample. According to the World Health Organization (WHO) criteria for diagnosing anemia, hemoglobin levels exceeding 12.0 g/dL indicate the absence of anemia. The study findings revealed that 59% of the participants were diagnosed with anemia due to their low hemoglobin levels. Substantial associations were observed between hemoglobin levels, anemia, and clinical factors such as chronic illnesses, heavy menstrual cycles, and dietary supplements. Based on these outcomes, anemia is highly prevalent among female university students. Furthermore, the research population may be susceptible to anemia if they engage in practices such as tea or coffee consumption, irregular meal patterns, or the intake of foods that impede iron absorption.
Восстановление модели теплового процесса по зашумленным данным
Authors: Андреева Т.А. , Быков Н.Ю. , Климова А.К. , Лукин А.Я.
Published: July 2023

A modification of the algorithm of generative design of the model in the form of a partial differential equation for working with noisy data is proposed. Using the algorithm, the model of the heat and mass transfer process was restored to synthetic and original experimental data on the heating of the environment by a flooded heat source. The thermophysical parameters of the medium are determined, the possibility of using the algorithm to indicate the convection process based on data on the space-time distribution of temperature is shown.