bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurovascular crossing patterns between leash of Henry and deep branch of radial nerve: implications for neurointervention and diagnostic imaging
Authors: Mohana-Borges Aurea V. R. , Silva Livia Tavane S. D. , Mohana-Borges Ronaldo S. , Statum Sheronda , Jerban Saeed , Wu Yuanshan , Barrère Victor , Souza Sergio A. L. , Chung Christine B.
Published: July 2024

Objective

To detail the neurovascular crossing patterns between the leash of Henry (LoH) and the deep branch of the radial nerve (DBRN) in supination and pronation of the forearm, using imaging methods with anatomic correlation.

Materials and methods

This cross-sectional study was performed ex vivo with HRUS and MRI with anatomic correlation on 6 samples and in vivo with HRUS with Doppler on 55 participants scanned bilaterally. The in vivo participants were enrolled over a 6-month period. The crossing patterns between the LoH and DBRN were assessed ex vivo and in vivo. Additional morphological features of the DBRN, LoH, and fat plane were assessed in vivo only. Biometric features of the participants were recorded. Statistical analyses were performed using Shapiro–Wilk, parametric and non-parametric tests.

Results

The most common neurovascular crossing pattern was the ascending branch of the radial recurrent artery (RRAab) crossing below (ex vivo: 83.3%, in vivo: 85.3%) and the muscular branch crossing above (ex vivo: 100%, in vivo: 63.2% %) the DBRN. Both the deep and superficial surfaces of the DBRN exhibited an intimate relationship with the vessels of the LoH. A positive correlation between vessel diameter and anthropometric factors was observed. In addition, the muscular branch exhibited a significantly smaller diameter than the RRAab.

Conclusion

Our study detailed the relationship between the LoH and the DBRN and highlighted the high incidence of vessel crossing above the DBRN at the level of the muscular branch. Knowledge of neurovascular crossings is crucial for understanding neurovascular entrapment syndromes and planning interventional procedures to reduce vascular complications.
Immunohistochemical ERG positivity is associated with decreased PSMA expression and lower visibility in corresponding [68Ga]Ga-PSMA-11 PET scans of primary prostate cancer
Authors: Rupp Niels J. , Freiberger Sandra N. , Ferraro Daniela A. , Laudicella Riccardo , Heimer Jakob , Muehlematter Urs J. , Poyet Cédric , Moch Holger , Eberli Daniel , Rüschoff Jan H. , Burger Irene A.
Published: July 2024

Purpose

TMPRSS2:ERG gene fusion negatively regulates PSMA expression in prostate adenocarcinoma (PCa) cell lines. Therefore, immunohistochemical (IHC) ERG expression, a surrogate for an underlying ERG rearrangement, and PSMA expression patterns in radical prostatectomy (RPE) specimens of primary PCa, including corresponding PSMA-PET scans were investigated.

Methods

Two cohorts of RPE samples (total n=148): In cohort #1 (n=62 patients) with available RPE and preoperative [68Ga]Ga-PSMA-11 PET, WHO/ISUP grade groups, IHC-ERG (positive vs. negative) and IHC-PSMA expression (% PSMA-negative tumour area, PSMA%neg) were correlated with the corresponding SUVmax. In the second cohort #2 (n=86 patients) including RPE only, same histopathological parameters were evaluated.

Results

Cohort #1: PCa with IHC-ERG expression (35.5%) showed significantly lower IHC-PSMA expression and lower SUVmax values on the corresponding PET scans. Eight of 9 PCa with negative PSMA-PET scans had IHC-ERG positivity, and confirmed TMPRSS2::ERG rearrangement. In IHC-PSMA positive PCa, IHC-ERG positivity was significantly associated with lower SUVmax values. In cohort #2, findings of higher IHC-PSMA%neg and IHC-ERG expression was confirmed with only 0-10% PSMA%neg tumour areas in IHC-ERG-negative PCa.

Conclusion

IHC-ERG expression is significantly associated with more heterogeneous and lower IHC-PSMA tissue expression in two independent RPE cohorts. There is a strong association of ERG positivity in RPE tissue with lower [68Ga]Ga-PSMA-11 uptake on corresponding PET scans. Results may serve as a base for future biomarker development to enable tumour-tailored, individualized imaging approaches.
Topographic Analysis of the Nipple–Areolar Complex Sensation in Superomedial Pedicle Breast Reduction
Authors: Sonmez Mehmet , Saglam Murat Enes
Published: July 2024

Background

Surgeons meticulously perform breast reductions, while ensuring vascular integrity of the pedicle and Nipple–Areolar complex (NAC) to prevent any complication. It is crucial to remember that loss of sensation is also substantial complication, mainly due to unique characteristic features of the NAC. This study aimed to compare early and long-term sensory results by performing topographic analysis of NAC sensation after superomedial pedicle breast reduction.

Methods

A prospective study was conducted by including nonrandomized female patients who underwent breast reduction surgery with wise pattern excision superomedial pedicle technique between January 2019 and June 2022. Semmes-Weinstein Monofilament (SWM) test performed at preoperatively, 3–6 months and 15–18 months postoperatively. NAC complex was divided into four equal quadrants and nipple: superomedial (SM), inferomedial (IM), inferolateral (IL), superolateral (SL) and Nipple (N). Touch-Test® Sensory Evaluator Chart was used to evaluate sensory results.

Results

None of the patients had any loss of sensation during preoperative SWM test. In postoperative 3–6 months, statistically significant differences were observed between N and SL (p = 0.002), SL and IM (p < 0.05), SM and IM (p < 0.05). In postoperative 15–18 months, there was no difference between the quadrants and nipple (p = 0.07). In early and long-term comparisons of the same quadrants, IL less pronounced than other quadrant comparisons (p = 0.034). A statistical difference was observed in overall NAC score (p < 0.05).

Conclusions

It would be beneficial to inform patients overall NAC sensation in the postoperative may not be as good as preoperative, there might be variations in NAC sensation across different quadrants in early period.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Poleward shifts in commercial fishing vessel distribution over the Bering Sea shelf, 2013–2022
Authors: Vlietstra Lucy S. , Thoenen Jake E.
Published: July 2024

Recent studies have documented poleward shifts in heavily targeted fish stocks on the Bering Sea Shelf. This study investigated whether commercial fishing vessels in the region have also shifted their distribution poleward in recent years. We used Vessel Management System data generated between January 1, 2013, and December 31, 2022, to identify regions over the shelf where vessel activity increased (emerging hot spots) and where it decreased (emerging cold spots) during this time period. We hypothesized that emerging hot spots would occur at the northern edge of the vessel operating range, while emerging cold spots would occur at the southern edge. Overall, northward shifts in vessel distribution were most evident during October–February and July–August, when the range of emerging hots spots was centered 204–515 km to the N, NE, or NW of the center of the range of emerging cold spots. The trend was strongest in August, when emerging hot spots were widespread in the Northern Bering Sea. We did not attempt to identify factors driving these distributional shifts, but the timing of shifts did coincide with the busiest fishing seasons over the Bering Sea Shelf and, in part, the open seasons for walleye pollock (Gadus chalcogrammus). If groundfish populations continue to move poleward with climate change, this study may serve as a window into the early stages of a long-term redistribution of commercial fishing effort in the Bering Sea, a region supporting one of the largest fishing industries in the world.
Drivers of the mean biases of the tropical atmospheric circulation in a moist static energy framework
Authors: Fan Chen-Shuo , Dommenget Dietmar
Published: July 2024

In this study, we apply the moist static energy for first baroclinic mode (MSEB) model to examine the drivers of the mean tropical atmospheric circulation biases over oceanic regions. The model diagnoses the vertical motion in an air column of the tropical regions based on net energy heat flux and advection of moisture or heat into the air column in relation to the stability of the air column due to the gradients in moist static energy. Analysis of Coupled Model Intercomparison Project (CMIP) and Atmospheric Model Intercomparison Project (AMIP) simulations helped to identified errors intrinsic to the atmospheric models or errors due to atmosphere–ocean coupling process. Despite some limitations of the MSEB model, our multi-model mean analysis over the entire tropical ocean reveals that the primary drivers of the tropical circulation biases mostly result from intrinsic atmospheric model errors in top of the atmosphere longwave radiation and surface latent heats fluxes, suggesting a link to biases in the hydrological cycle. Oceanic coupling significantly enhanced some of the biases. Biases in the advection of moist static energy also play an important role, while biases in the gross moist stability profiles play only a minor role. Further, we examine the inter-model variations in four main regional large-scale biases (double-ITCZ, Pacific cold tongue, southward shift of ITCZ over the Atlantic, and dipole bias over the Indian Ocean). The analysis suggests that regional bias patterns across general circulation models are primarily driven by coupling errors, except for the bias in the Indian Ocean, which is intrinsic to the atmospheric model but amplified by coupling. Notably, longwave radiation biases at the top of the atmosphere are prevalent among the four bias patterns, as well as biases in moisture advection over the Atlantic. Our results underscore the significant role of net longwave radiation at the top of the atmosphere, an aspect not sufficiently emphasized in previous studies.
Effect of whey protein-derived decapeptide on mood status and blood variables in healthy adults: a randomized, double-blind, placebo-controlled cross-over trial
Authors: Suzuki Katsuya , Okamatsu Yoriko , Uchida Ryo , Sasahara Ikuko , Takeshita Masamichi , Sato Wataru , Kitahara Yoshiro , Murakami Hitoshi
Published: July 2024

Purpose

The importance of maintaining good mental health with overall well-being has recently drawn attention from various fields. Functional peptides found from various protein sources reportedly reduce mental health problems. We found a new decapeptide (AJI-801) from whey proteins, which can possibly improve mood status and increase blood acetyl-L-carnitine (ALC) and fibroblast growth factor 21 (FGF21) levels. In this study, we assessed the effects of a single intake of whey protein hydrolysate containing a high amount of AJI-801 (WPH) on blood variables and mood status.

Methods

A randomized, double-blind, placebo-controlled cross-over trial of two doses of WPH (100 and 500 mg) was conducted. Participants, aged between 20 and 59 years with fatigue were allocated to two groups based on the WPH doses received, and set first test food in each study. The blood ALC and FGF21 levels at baseline and after 60, 120, and 180 min of test food intake were analyzed and the responses to the questionnaire items for mood status were obtained at baseline and after 60 and 180 min of test food intake.

Results

There were no significant differences in the blood ALC and FGF21 levels between the two groups. As mood status, intake of 500-mg WPH (including 2.5-mg AJI-801) showed significant improvement in Depression/Dejection of the Profile of Mood States Questionnaire second edition and visual analog scale score for depression, as compared to the placebo.

Conclusions

Intake of AJI-801 500-mg WPH (including 2.5-mg AJI-801) contributes to the improvement of feeling down in healthy persons with fatigue.

Trial registration

University Hospital Medical Information Network Clinical Trial Registry (UMIN 000046829).
Prediction of bone invasion of oral squamous cell carcinoma using a magnetic resonance imaging-based machine learning model
Authors: Öztürk Elif Meltem Aslan , Ünsal Gürkan , Erişir Ferhat , Orhan Kaan
Published: July 2024

Objectives

Radiomics, a recently developed image-processing technology, holds potential in medical diagnostics. This study aimed to propose a machine-learning (ML) model and evaluate its effectiveness in detecting oral squamous cell carcinoma (OSCC) and predicting bone metastasis using magnetic resonance imaging (MRI).

Materials-methods

MRI radiomic features were extracted and analyzed to identify malignant lesions. A total of 86 patients (44 with benign lesions without bone invasion and 42 with malignant lesions with bone invasion) were included. Data and clinical information were managed using the RadCloud Platform (Huiying Medical Technology Co., Ltd., Beijing, China). The study employed a hand-crafted radiomics model, with the dataset randomly split into training and validation sets in an 8:2 ratio using 815 random seeds.

Results

The results revealed that the ML method support vector machine (SVM) performed best for detecting bone invasion (AUC = 0.999) in the test set. Radiomics tumor features derived from MRI are useful to predicting bone invasion from oral squamous cell carcinoma with high accuracy.

Conclusions

This study introduces an ML model utilizing SVM and radiomics to predict bone invasion in OSCC. Despite the promising results, the small sample size necessitates larger multicenter studies to validate and expand these findings.
Impact of preocular and ocular circulatory dynamics on the vascular density of retinal capillary plexuses and choriocapillaris
Authors: Vallée Rodolphe , Körpe Dilsah , Vallée Jean-Noël , Tsiropoulos Georgios N. , Gallo Castro Daniela , Mantel Irmela , Pournaras Constantin J. , Ambresin Aude
Published: July 2024

Purpose

To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.

Methods

A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FAAT), start (FAstartLF) and end (FAendLF) of laminar flow, and arterial time (ICGAAT), respectively. OCT angiography VDs were superficial (VDSCP) and deep (VDDCP) RCPs and CC (VDCC) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.

Results

177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VDSCP and VDDCP were significantly inversely correlated with FAAT, FAstartLF and FAendLF likewise VDCC with ICGAAT. Correlations were stronger in patients without CVR than with CVR. CVR, FAAT, FAstartLF and FAendLF were more strongly correlated with VDDCP than VDSCP. FAAT, FAstartLF and FAendLF significantly impacted VDSCP and VDDCP, likewise ICGAAT impacted VDDCP. VDDCP was most strongly impacted by FAAT and FAstartLF.

Conclusion

Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.
The Complexity of Finding and Enumerating Optimal Subgraphs to Represent Spatial Correlation
Authors: Enright Jessica , Lee Duncan , Meeks Kitty , Pettersson William , Sylvester John
Published: July 2024

Understanding spatial correlation is vital in many fields including epidemiology and social science. Lee et al. (Stat Comput 31(4):51, 2021. https://doi.org/10.1007/s11222-021-10025-7) recently demonstrated that improved inference for areal unit count data can be achieved by carrying out modifications to a graph representing spatial correlations; specifically, they delete edges of the planar graph derived from border-sharing between geographic regions in order to maximise a specific objective function. In this paper, we address the computational complexity of the associated graph optimisation problem. We demonstrate that this optimisation problem is NP-hard; we further show intractability for two simpler variants of the problem. We follow these results with two parameterised algorithms that exactly solve the problem. The first is parameterised by both treewidth and maximum degree, while the second is parameterised by the maximum number of edges that can be removed and is also restricted to settings where the input graph has maximum degree three. Both of these algorithms solve not only the decision problem, but also enumerate all solutions with polynomial time precalculation, delay, and postcalculation time in respective restricted settings. For this problem, efficient enumeration allows the uncertainty in the spatial correlation to be utilised in the modelling. The first enumeration algorithm utilises dynamic programming on a tree decomposition of the input graph, and has polynomial time precalculation and linear delay if both the treewidth and maximum degree are bounded. The second algorithm is restricted to problem instances with maximum degree three, as may arise from triangulations of planar surfaces, but can output all solutions with FPT precalculation time and linear delay when the maximum number of edges that can be removed is taken as the parameter.
Integrated operating room planning and scheduling: an ILP-Based off-line approach for emergency responsiveness at a local hospital in Naples
Authors: Boccia Maurizio , Mancuso Andrea , Masone Adriano , Sterle Claudio
Published: July 2024

This paper addresses a real-world Integrated Operating Room Planning and Scheduling (IORPS) problem encountered by a local hospital in Naples, characterized by stringent emergency management constraints, requiring treatment initiation within a 20-minute time-window. We tackle this problem by an original Integer Linear Programming formulation, capable of dealing with different operating room management strategies (open, block and block-modified). Our work differs from conventional cost-focused models by adopting a patient-oriented objective function, aligning with public hospitals obligations. The proposed method has been validated using real-world data provided by the hospital. The performed experimentation demonstrates the efficiency of the approach, capable of determining the optimal solution within an acceptable computation time that aligns with hospital requirements. Moreover, it also highlights the relevance of using our optimization approach to reduce delays in emergency responsiveness. This confirms its practical usage as a substitute for the current manual procedure.
A biased random-key genetic algorithm for the knapsack problem with forfeit sets
Authors: Cerulli Raffaele , D’Ambrosio Ciriaco , Raiconi Andrea
Published: July 2024

This work addresses the Knapsack Problem with Forfeit Sets, a recently introduced variant of the 0/1 Knapsack Problem considering subsets of items associated with contrasting choices. Some penalty costs need to be paid whenever the number of items in the solution belonging to a forfeit set exceeds a predefined allowance threshold. We propose an effective metaheuristic to solve the problem, based on the Biased Random-Key Genetic Algorithm paradigm. An appropriately designed decoder function assigns a feasible solution to each chromosome, and improves it using some additional heuristic procedures. We show experimentally that the algorithm outperforms significantly a previously introduced metaheuristic for the problem.
Evaluation of the effect of adjunctive diode laser application on peri-implant crevicular fluid biomarker levels: a randomized controlled trial
Authors: Erduran Nazan Ece , Guncu Guliz N. , Akman Abdullah C. , Acar Buket , Pinar Asli , Karabulut Erdem , Nohutcu Rahime M.
Published: July 2024

Objectives

To assess both the clinical and immunological effectiveness of diode laser therapy when used as an adjunct to non-surgical mechanical therapy in managing peri-implantitis.

Materials and methods

A cohort of 27 participants, comprising 21 females and 6 males, agreed to take part in this investigation. 37 dental implants with peri-implantitis diagnosis were randomly allocated to either the laser group (n = 19) or the control group (n = 18). Evaluation of peri-implant clinical parameters and collection peri-implant crevicular fluid (PICF) samples occurred at baseline, as well as at 3 and 6-month follow-up intervals. The level of various biomarkers (TWEAK, IL-1β, sclerostin, IL-17, RANKL, OPG and IL-10) within the PICF were quantified using enzyme-linked immunosorbent assay.

Results

Significant time-dependent decreases in clinical and biochemical parameters were detected in both groups compared to the baseline. There were marked differences between the groups in terms of periodontal parameters, except probing depth, and IL-1β, IL-17, sclerostin levels in PICF at 3rd month follow-up. However, no statistically significant difference was detected at 6th month.

Conclusions

Diode laser seems to be a reliable tool as an adjunct for supporting the nonsurgical mechanical treatment during the early stages of peri-implantitis. Furthermore, the findings suggest that IL-17, sclerostin and IL-1β may serve as promising biomarkers for assessing efficacy of peri-implantitis treatment.

Clinical relevance

Based on these outcomes, clinicians may consider the application of adjunctive use of diode laser to non-surgical peri-implantitis treatment to achieve better clinical and immunological improvements than nonsurgical peri-implantitis therapy alone in just early healing period. However, it should be noted that there was no difference between the two methods in the long term.
Relationship between fundus sex index obtained using color fundus parameters and body height or axial length in the Kumejima population
Authors: Yamashita Takehiro , Asaoka Ryo , Iwase Aiko , Sakai Hiroshi , Terasaki Hiroto , Sakamoto Taiji , Araie Makoto
Published: July 2024

Purpose

To investigate the relationship between the fundus sex index obtained from fundus photographs and body height or axial length in the Kumejima population.

Study Design

Prospective cross-sectional observational population study.

Methods

Using color fundus photographs obtained from the Kumejima population, 1,653 healthy right eyes with reliable fundus parameter measurements were included in this study. The tessellation fundus index was calculated as R/(R + G + B) using the mean value of the red-green-blue intensity in the eight locations around the optic disc and foveal region. The optic disc ovality ratio, papillomacular angle, and retinal vessel angle were quantified as previously described. The masculine or feminine fundus was quantified using machine learning (L2 regularized binominal logistic regression and leave one out cross validation), with the range of 0–1 as the predictive value, and defined as the fundus sex index. The relationship between the fundus sex index and body height or axial length was investigated using Spearman’s correlation.

Results

The mean age of the 838 men and 815 women included in this study was 52.8 and 54.0 years, respectively. The correlation coefficient between fundus sex index and body height was − 0.40 (p < 0.001) in all, 0.01 (p = 0.89) in men, and − 0.04 (p = 0.30) in women, and that between fundus sex index and axial length was − 0.23 (p < 0.001) in all, − 0.12 (p < 0.001) in men, and − 0.13 (p < 0.001) in women.

Conclusion

This study shows that a larger number of masculine fundi tend to have longer axial lengths in each sex group. However, sex index was not significantly related with body height either in men or in women.
Effect of a silvopastoral system with Leucaena diversifolia on enteric methane emissions, animal performance, and meat fatty acid profile of beef steers
Authors: Molina-Botero Isabel Cristina , Villegas Daniel M. , Montoya Alejandro , Mazabel Johanna , Bastidas Mike , Ruden Alejandro , Gaviria Hernan , Peláez Juan David , Chará Julián , Murgueitio Enrique , Moorby Jon , Arango Jacobo
Published: July 2024

The aim of this research was to evaluate dietary inclusion of Leucaena diversifolia into a grass monoculture (GM) diet and its influence on enteric methane emissions, animal live weight gain and meat fatty acid content of steers. Two GM diets comprised Urochloa hybrid cv. Cayman or U. brizantha cv. Toledo; silvopastoral (SPS) mixed diets included an association of either grass with L. diversifolia in a 74:26 (grass:legume) planting ratio. The experiment was conducted over 16 months with 14 Brahman x Angus crossbred steers (374±7.5 kg body weight), divided into two diet groups. Steers were weighed periodically during the experiment, and methane emissions were quantified with the polytunnel technique. The meat quality and fatty acid profile were measured after slaughtering the steers. Energy density, total and digestible dry matter intake and crude protein were higher in steers fed SPS than GM (P≤0.05). At the end of the experiment, animals from SPS weighed on average 63 kg more than animals offered GM (535 vs. 472 kg; P=0.025). Net methane emitted by steers offered SPS was 142 g per day, this is equivalent to 15% less than emissions from animals that were offered GM (168 g; P=0.007). The meat fatty acid profile was similar between diets, except for cervoniv-DHA and omega-6: omega-3 ratio, which were higher in steers consuming GM diet (P≤0.05). The results of this study suggest that the inclusion of L. diversifolia improves nutrient intake, increases animal productivity, reduces daily enteric methane emission, and decreases the omega-6: omega-3 ratio in meat.
Pogonoloma macrorhizum (Basidiomycota, Agaricales) in Slovak landscape: a distinct fungus of Quercus cerris stands transitional in space and time
Authors: Kunca Vladimír , Holec Jan , Olah Branislav , Zehnálek Petr , Kučera Tomáš
Published: July 2024

The lack of precise data on the environmental requirements of the conspicuous fungus with a northern distribution limit in Slovakia, Pogonoloma macrorhizum, initiated our study. Its identity was verified by sequencing of ITS and 28 S nrDNA regions. The analysis of trophic status by stable-isotope ratio of carbon and nitrogen suggested that the species is probably ectomycorrhizal. For the seventeen sampling sites, environmental data were obtained and information on landscape development and management were retrieved from historical maps and aerial orthophotographs. All these parameters were analysed by multivariate ordination methods. In Slovakia, P. macrorhizum is found in thermophilous to mesophilous stands on acidic soils with a pH ranging from 4.1 to 6.2. These habitats are dominated by Quercus cerris, with non-frequent tree taxa of Carpinus betulus and Quercus petraea agg. The key environmental drivers shaping the habitat of P. macrorhizum were identified as time since deforestation, with the presence of old Q. cerris individuals (former solitary trees of pastures) and soil characteristics. The fungus appears to be a species of transitional habitats historically affected by grazing. These transitions occur between thermophilic and mesophilic sites, including oak forest communities, dry steppic grasslands and forest edges, as well as spontaneously overgrown pastures and forests with a closed canopy. It is regrettable that the Q. cerris stands in Slovakia are under threat, particularly because of felling and the lack of grazing in forests. Furthermore, recent silvicultural practices have resulted in the replacement of oaks (Quercus spp.) by hornbeam (Carpinus betulus) and the formation of closed stands.
Experimental and numerical investigation of the solid cold-welding properties of the APB process of Al/Cu bulk composites
Authors: Bandhu Din , Altayeh Aiham O. , Ghazaly Nouby M. , Juraev Nizomiddin , Ibrahim Muwafaq Khazaal , Reddy R. Meenakshi , Naderian F.
Published: July 2024

Nowadays, the use of bimetallic laminates with special capabilities is increasing and has experienced high growth. These properties include high mechanical properties, corrosion resistance, lightweight, and thermal stability. Among the technologies of multilayer composite materials, Accumulative Press Bonding (APB) as a solid-phased method of welding is one of the most common techniques for the production of multilayer composites. One of the most important aims for this choice is the press pressure, which can create a strong and suitable mechanical connection between produced metal layer components. In this study, the APB method has been used to produce bimetal aluminum/copper bulk composites as its novelty for the first time. After that, the effect of pressing parameters such as strain and number of layers on the stress distribution has been investigated. The shear stress among the layers reached 4 MPa for the samples with eight layers which is a good condition to generate a successful bonding. With increasing the thickness reduction ratio, the stress applied to the layers has also increased. As the thickness decreases, the interlayer shear stresses also increase which leads to a better bonding between layers. With increasing the thickness reduction ratio, the amount of layers sinking in each other was greater than before, which led to the crushing of copper layers along the entire length of the sample. During the process, as the number of passes increased, the volume of virgin material in the direction of the press rose, which led to increased compaction and better adhesion of Al and Cu layers to each other. The bonding strength enhances from 47 to 95 N for samples manufactured with one and four cycles of APB due to the increment of virgin metal normal to the pressing direction showing a 102% enhancement.
Preliminary investigation of a wearable device for evaluating muscular effort and fatigue at workplace
Authors: Papetti Alessandra , Mandolini Marco , Brunzini Agnese , Germani Michele
Published: July 2024

Controls and prevention activities for musculoskeletal disorders are increasingly encouraged in the industrial context. Several ergonomic assessment techniques exist. However, they primarily focus on the biomechanical and postural load requirements of job tasks and rely on self-report and observational methods rather than direct measurements, which are often too intrusive. This study investigates whether a commercially available low-intrusive and low-cost wearable sensor can be utilised to assess muscular effort and fatigue, thereby improving decision-making in work and workstation design. For this purpose, the potential of the Myo™ armband has been explored. The electrical activity of the upper limbs (arm and forearm) was evaluated through 15 physically tasks (manual handling and assembly) conducted in laboratory conditions. Satisfactory results were obtained from the correlation and significance analysis, considering the EMG signal, the Borg scale, and the activity level (e.g., load, distance, n° of repetitions). Further experimentation was conducted to validate the proposed approach in a real production facility.
Mesenchymal stromal cells and their secretory products reduce the inflammatory crosstalk between islets and endothelial cells
Authors: Dewhurst-Trigg Rebecca , Hopkinson Jessica , Richardson Sarah , Jones Peter , Rackham Chloe
Published: July 2024

Purpose

Preculturing isolated islets with Mesenchymal Stromal Cells (MSCs) improves their functional survival in vitro and subsequent transplantation outcomes in vivo. The MSC secretory product Annexin A1 (ANXA1) is a key modulator of MSC-mediated improvements in islet function. The current study aims to determine the influence of MSCs and defined MSC secretory products, including ANXA1, on the inflammatory crosstalk between isolated islets and Endothelial Cells (ECs), using in vitro models of the clinically-preferred intraportal islet transplantation niche.

Methods

Islets were cultured alone, with MSCs, or with MSC secretory products and exposed to pro-inflammatory cytokines. Islet gene expression of C-C Motif Chemokine Ligand 2 (CCL2), C-X-C Motif Chemokine Ligand (CXCL)-10 (CXCL10) and CXCL1 were assessed by RT-qPCR. EC activation was induced with 100 U/ml TNF for 24 h. Islet-EC co-cultures were used to determine the influence of MSCs, or MSC secretory products on the inflammatory crosstalk between isolated islets and ECs. VCAM-1 and ICAM-1 expression were assessed at the mRNA and protein level in ECs, using RT-qPCR and immunofluorescence.

Results

MSCs reduce pro-inflammatory cytokine-induced islet CCL2, CXCL10, and CXCL1 gene expression, which is partially mimicked by ANXA1. MSCs and ANXA1 have a similar capacity to reduce TNF-induced EC activation. Isolated islets exacerbate TNF-induced EC activation. Preculturing islets with MSCs reduces islet-exacerbated EC activation. ANXA1 reduces islet-exacerbated EC activation, when present during the islet preculture and islet-EC co-culture period.

Conclusion

MSC-derived secretory factors, including ANXA1, may be used in islet transplantation protocols to target donor islet and host EC inflammation at the intraportal niche.
Socioeconomic Factors Determining Multidimensional Child Poverty Groups in Central America: A Measurement Proposal from the Wellbeing Approach Using a Comprehensive Set of Children’s Rights
Authors: Guillén-Fernández Yedith B.
Published: July 2024

This article aims to show that multidimensional child poverty (MCP) is determined by several socioeconomic factors that influence the formation of stratified groups of poor children under five years of age living in Central America. This study advocates for a comprehensive set of children's rights with the purpose of addressing the different facets of child poverty from the perspective of child well-being, in order to estimate the incidence of MCP, by including multiple childhood deprivations and socioeconomic determinants. Child-specific indicators and household deprivation indicators are considered in the estimation of MCP. The study also states that child poverty is a complex concept, which includes the various types of deprivations experienced by children in the Central American societies and their deprivations are considered as the denial of children’s rights. Therefore, the MCP is estimated based on a conditional latent class analysis that includes not only manifest deprivation variables, but also socioeconomic determinants that help to better predict the incidence and probabilities of children being multidimensionally poor according to different poverty strata. The socioeconomic factors that show high risks of MCP are rural areas, indigenous children, young mothers and low levels of education attained by the head of the household, among others. One of the reasons to investigate the MCP for Belize and El Salvador is because there are few studies that address this problem for these countries and this research sheds light on the characteristics of early childhood poverty. The results indicate that the incidence of MCP is 49% in Belize and 76% in El Salvador. The research work concludes that the International Rights of the Child provide the opportunity to implement comprehensive social policies in Central America to eradicate child poverty.
On analysis of a system of non-homogenous boundary value problems using hausdorff derivative with exponential kernel
Authors: Ullah Shafi , Shah Kamal , Sarwar Muhammad , Hleili Manel , Ali Arshad , Abdeljawad Thabet
Published: July 2024

In recent years, the fractals (Hausdorff) derivatives with fractional order under various types kernel have gained attention from researchers. The aforesaid area has many applications in the description of intricate and irregular geometry of various processes. Numerous studies utilizing the fractional derivatives (HFDs) for initial value problems have been carried out. But the boundary value problems using the said concepts have been very rarely studied. Thus, a coupled system with non-homogenous boundary conditions (BCs) is examined in this study by using fractals fractional derivative in Caputo Fabrizio sense. To establish the required conditions for the existence and uniqueness of solution to the considered problem, we apply the Banach and Krasnoselskii’s fixed point theorems. Furthermore, some results related to Hyers-Ulam (H-U) stability have also deduced. We have included two pertinent examples to verify our results.
Carbon Dioxide Fluxes from Peri-urban Tidal Flats in South China
Authors: Chen Zhao Liang , Lee Shing Yip
Published: July 2024

Coastal ecosystems are recognized as important carbon reservoirs. However, assessments of coastal carbon dioxide (CO2) fluxes often neglect unvegetated tidal flats, particularly in peri-urban areas. This study investigated the gross primary production (GPP), net primary production (NPP), and total respiration (TR) of three tidal flats in Hong Kong, one of the largest cities in South China, during both summer and winter seasons to understand their CO2 fluxes. Results showed that GPP of three tidal flats was significantly higher in winter than in summer. However, no significant seasonal variations in TR were observed among the tidal flats. Structural equation modelling was used to examine the drivers of CO2 fluxes in the three tidal flats. The model showed that temperature and microphytobenthos abundance were identified as positive drivers of GPP, while sediment mud content had a positive effect on TR. The estimated daily NPP of these tidal flats ranged from -0.853 to 0.112 g C m−2 d−1, which is lower than the mean value reported for global vegetated coastal wetlands. Despite some seasonal and spatial variations, those peri-urban tidal flats may be considered as weak CO2 sources rather than CO2 sinks.
Battery-electric powertrain system design for the HorizonUAM multirotor air taxi concept
Authors: Jäger Florian , Bertram Oliver , Lübbe Sascha M. , Bismark Alexander H. , Rosenberg Jan , Bartscht Lukas
Published: July 2024

The work presented herein has been conducted within the DLR internal research project HorizonUAM, which encompasses research within numerous areas related to urban air mobility. One of the project goals was to develop a safe and certifiable onboard system concept. This paper aims to present the conceptual propulsion system architecture design for an all-electric battery-powered multirotor electric Vertical Takeoff and Landing (eVTOL) vehicle. Therefore, a conceptual design method was developed that provides a structured approach for designing the safe multirotor propulsion architecture. Based on the concept of operation the powertrain system was initially predefined, iteratively refined based on the safety assessment and validated through component sizing and simulations. The analysis was conducted within three system groups that were developed in parallel: the drivetrain, the energy supply and the thermal management system. The design process indicated that a pure quadcopter propulsion system can merely be designed reasonably for meeting the European Union Aviation Safety Agency (EASA) reliability specifications. By adding two push propellers and implementing numerous safety as well as passivation measures the reliability specifications defined by EASA could finally be fulfilled. The subsequent system simulations also verified that the system architecture is capable of meeting the requirements of the vehicle concept of operations. However, further work is required to extend the safety analysis to additional system components as the thermal management system or the battery management system and to reduce propulsion system weight.
Stability of Saltwater‐Freshwater Mixing Zones in Beach Aquifers With Geologic Heterogeneity
Authors: Olorunsaye Olasunkanmi , Heiss James W.
Published: July 2024

Saltwater‐freshwater mixing zones in beach aquifers support biogeochemical reactions that moderate chemical loads in fresh groundwater discharging to marine ecosystems. Existing laboratory and numerical modeling studies have demonstrated that fluid density gradients in the mixing zone can lead to free convection and the formation of density instabilities, or salt fingers, under a range of hydrologic, morphologic, and hydrogeologic conditions. However, salt fingers have rarely been observed in real‐world beach aquifers despite a growing body of field studies investigating intertidal mixing zones. In this study, we used geostatistical methods to generate randomly distributed assemblages of fine and medium sand and incorporated those geologic realizations into variable‐density variably‐saturated flow and salt transport simulations to explore the influence of geologic structure on mixing zone stability in tidally‐influenced beaches. Ensemble‐averaged model results show that geologic heterogeneity inhibits salt finger formation and promotes a stable intertidal mixing zone due to enhanced dispersion. This effect is highest for high degrees of heterogeneity and for more laterally connected geologic architecture. Compared to hydraulically equivalent homogeneous models, sediments with moderate to high heterogeneity produce mixing zones that are on average 19%–29% smaller and 3–10 times more stable due to the absence of the downward convection and seaward movement of salt fingers. The models indicate that geologic heterogeneity may explain the lack of field observations of salt fingers in real‐world intertidal mixing zones. The findings have implications for predicting the onset of free convection in beaches and for understanding intertidal pore water biogeochemistry and chemical fluxes to the ocean.
Quantification of Mixing Depth Using the Gradient Richardson Number in Submerged Aquatic Vegetation Meadows
Authors: Matsumoto H. , Nakayama K.
Published: July 2024

Upper layer thickness (mixing depth) is an essential parameter for estimating the dissolved inorganic carbon and carbon flux at the water surface based on their association with the vertical flux of dissolved inorganic carbon. Previous studies quantified the mixing depth without SAV meadow or penetration depth in the SAV meadow without stratification and wind stress. However, mixing depth related to interaction with submerged aquatic vegetations (SAVs), stratification, and wind stress has yet to be quantified in the previous studies. Our study is the first to quantify the theoretical mixing depth with SAVs according to wind stress, SAV height, and drag coefficient. Theoretical mixing depth was quantified from modeled vertical temperature profile, vertical profile of horizontal velocity, and gradient Richardson number (Rig,veg). We found that mixing depth at a Rig,veg of 100 demonstrated good agreement with numerical results on average, with the mixing depth estimated in this study (hU,this study) showing high applicability to observations at Komuke Lagoon. Moreover, hU,this study increased with the increasing wind stress and decreasing drag coefficient and SAV height. Further, we found that SAV meadows with stratification and wind stress could be divided into four hydrodynamic regimes: non‐vegetated layers, upper vegetated layers, thermoclines, and benthic boundary layers. Our findings help us estimate mixing depth or vertical flux without complicated numerical simulation and understand flow interaction with SAV, wind stress, and stratification.
Enhanced Carbon Accumulation in China's New Coastal Wetlands Over the 21st Century
Authors: Shen Xiaoyi , Ke Chang‐Qing , Cai Yu , Li Haili , Xiao Yao
Published: July 2024

Wetlands formed by natural sediment deposition account for a large proportion of new coastal lands, and these new wetlands usually have active ecosystems and obvious ecological effects. However, previous studies largely overlooked this sediment‐caused wetland expansion, and the spatiotemporal variation in these wetlands and future response to sea‐level rise (SLR) have not been determined. Here, we employed satellite observations to quantify the seaward expansion of coastal lands in China over the past two decades. A total land expansion of 6,651 km2 was found, and wetlands and artificial surfaces dominated, accounting for 32% and 25%, respectively. Subsequently, we utilized an integrated model to estimate the response of these new wetlands to SLR in the 21st century, that is, we estimated the wetland gain from sediment deposition and loss due to SLR. The results indicate that under the current condition of sediment availability, the area of China's new coastal wetlands is projected to increase by 200%–261% compared to that in 2020 based on four SLR scenarios, despite the unavoidable impact of SLR. These increases are accompanied by the continuous enhancement of carbon accumulation. Wetland changes are influenced by factors such as sediment deposition, SLR and storm surges, as well as the continued effect of local natural and anthropogenic factors. These results show the importance of understanding the ecological effects of new wetlands and constructing specific protection measures for sustainable development.
Impacts of Massive Topographies on Heat Waves in Global Drylands
Authors: Tan Ziyuan , Liu Yuzhi , Li Dan , Tang Weiqi , Gao Jie , Dong Xuefeng
Published: July 2024

Large‐scale topographies affect global extreme weather and climate though dynamic and thermal forcing. However, the impacts of typical topographies on heat waves in different drylands globally remain unclear. In this study, we find that heat waves are mainly occurred in global drylands during 1940–2022. The frequencies and intensities of heat waves in global drylands have significantly increased after 1980s. Multiple numerical model simulations reveal that the impact range of Asian topography on heat waves in global drylands is widest, not only in East Asia, Central, and west Asia locally, but also can reach as far as North Africa and North America. While the impact ranges of topographies in Africa, Arabian Peninsula, North America, and South America on heat waves in drylands are relatively narrow, which are concentrated in localized and their surroundings. These conclusions could provide clues to understand the influence of topography on global weather and climate extremes.
Evaluating initial screening practices for calcium dysregulation after acute traumatic spinal cord injury: a retrospective review
Authors: Chaggar Rajbir , Gill Ranjodh
Published: July 2024

Objectives

The purpose of this study was to determine the frequency of which calcium homeostasis markers are obtained in the acute setting after an initial traumatic spinal cord injury (TSCI).

Design

Retrospective chart review of a limited data set linking ICD 10 codes designating TSCI to corresponding calcium homeostasis markers for patients with an initial chart encounter for TSCI.

Setting

A level 1 trauma center in Virginia, United States

Methods

The statistical software SPSS was used to calculate summary statistics including frequency, mean, and standard deviation for calcium homeostasis markers (basic metabolic panel, magnesium, spot urine calcium, testosterone panel, liver function tests, Vitamin D level, C-telopeptide, parathyroid hormone, celiac panel, DXA imaging report) as well as the mean and standard deviation for time to first check of the marker.

Results

Most markers were not obtained besides calcium. Only 10 of 80 (12.5%) of subjects had a Vitamin D level (mean 28, SD 23) checked during acute admission (mean days to check 1.5, SD 1.6), with most other markers checked much less frequently.

Conclusions

Most calcium homeostasis markers were not checked on acute admission after TSCI. Future studies on implementing a standardized calcium homeostasis marker protocol for monitoring and potential medical intervention should be explored.