bluuebunny/crossref_metadata_2025 huggingface dataset:
A polifonia da existência: aportes metodológicos para uma pesquisa biográfica em perspectiva antropológica
Authors: Silva Anaxsuell Fernando
Published: July 2019

O gênero biográfico tem alcançado ultimamente grande sucesso. Tanto entre o públicoacadêmico quanto entre o público em geral, tal fenômeno mundial registra ocorrênciaem diversas áreas do conhecimento, dentre as quais podem-se destacar o jornalismo e aliteratura. As ciências sociais, especialmente a antropologia, ainda de maneira tímida, buscamcontribuir epistemologicamente com esse campo. Neste artigo, objetivamos apresentaralguns apontamentos teórico-metodológicos a respeito da pesquisa e escrita biográfica,notadamente o dissenso entre Bourdieu e Sartre. E, como alternativa metodológica,apresentamos as discussões de Roland Barthes a respeito da noção de romance polifônico.Nosso objetivo é construir um espaço de debate privilegiado na interlocução entre teorias,fontes, métodos e abordagens. E, a partir da construção desse espaço comunicacional,discutiremos os modos de apreensão de uma experiência pessoal e as formas de reavaliação ereconstrução do passado a partir das relações entre indivíduos, grupos e sociedade, para quese possa explicitar os mecanismos culturais e políticos de sua produção, a partir de dimensõescoletivas e institucionais que atuam em narrativas de afirmação/construção da história.
Memorial
Authors: Cano Ignacio
Published: July 2019

Memorial para concorrer à promoção à Professor Titular.
‘The future's extremely bright’
Authors: Grieve Paula
Published: July 2019

Paula Grieve, oversight and monitoring lead at Bupa Dental Care, enlightens us about her career
The Moroccan experience
Authors: Box Rosie
Published: July 2019

Receptionist Rosie Box reveals how volunteering inspired her to train as a dental nurse
New onset of diabetes after transplant
Authors: Egan Lisa , Sheejo Sini
Published: July 2019

New onset of diabetes after transplant (NODAT) is the development of diabetes post-transplant secondary to both insulin resistance and insulin insufficiency, which can be exacerbated by immunosuppressant medication. This article discusses the diagnosis of NODAT, as well as the available ways of managing this condition
Öğretmen Adaylarının Matematik Öğretimine Yönelik Eğitsel Dijital Oyun Tasarımlarının ve Tasarım Sürecine ilişkin Görüşlerinin İncelenmesi
Authors: YILDIZ DURAK Hatice , KARAOĞLAN YILMAZ Fatma Gizem
Published: July 2019

Bu çalışmanın amacı öğretmen adaylarının matematik
öğretimine yönelik eğitsel dijital oyun tasarımlarının ve tasarım sürecine
ilişkin görüşlerinin incelenmesidir. Araştırmada nitel araştırma desenlerinden
durum çalışması kullanılmıştır. Katılımcılar bir devlet üniversitesinde
İlköğretim Matematik Öğretmenliği üçüncü sınıfında öğrenim görmekte olan toplam
30 öğretmen adayıdır. Bu çalışmada yarı yapılandırılmış görüşme formu
kullanılmış ve öğrenci projeleri incelenmiştir. Katılımcılar 14 hafta süren
Matematik öğretimini amaçlayan bir eğitsel dijital oyun tasarlama sürecine
dahil edilmişlerdir. Çalışmada nitel verilerin yanı sıra katılımcıların
hazırladıkları oyunlar analiz edilmiştir. Araştırma sonuçları, öğretmen
adaylarının görüşlerine göre, eğitsel dijital oyun tasarlama sürecinin akademik
alanda en çok problem çözme becerilerini geliştirdiğini, yaratıcılık
kazandırdığını, matematik alanında teknolojiyi kullanabilme yeterlilikleri
geliştirdiğini; teknoloji yeterliliği bağlamında öğretmen adaylarının en çok
teknoloji kullanma yeterliliği kazanma noktasında gelişim gösterdiğini göstermiştir.
Can meso-governments use metagovernance tools to tackle complex policy problems?
Authors: Connell Andrew , Martin Steve , St Denny Emily
Published: July 2019

In recent years, a range of countries have devolved significant powers, responsibilities and funding to the regional level. This paper explores how and why the resulting meso-governments may use the tools of metagovernance. A detailed empirical analysis of homelessness policy in Wales found that skilful deployment of metagovernance tools enabled its meso-government to exploit the advantages of geographical and relational proximity to policy communities, while mitigating some of the constraints of its intermediate constitutional status, including limited formal powers and policy capacity. Junior government officials played multiple roles in homelessness networks, shaping and steering them through active network management while also participating in them. This ‘governor-participant’ role blurs the distinction made in the existing literature between ‘hands-on’ and ‘hands-off’ metagovernance tools. It also shows that, in the case of meso-governments at least, it is possible for low-ranking officials to exercise greater agency in policy development than has previously been assumed.
Digital government, public participation and service transformation: the impact of virtual courts
Authors: Moore Sarah
Published: July 2019

Governments around the world are building online infrastructures which they hope will become the main channels through which they interact with citizens. This new, globally dominant orthodoxy in policymaking is closely tied to design-thinking which claims that digital technology addresses the dual crises of state capacity and public trust. Through an examination of virtual courts, this paper offers a critical analysis of the organising principles and the effects of the digital government revolution. It shows that virtual courts reconfigure the role of the public in ‘seeing justice being done’, leading to the emergence of a new ‘visuality of technocracy’. However, it questions the claim that digital technology will transform public services and increase public trust. Creating new virtual spaces and interfaces is not a costless endeavour and, while it may make public services more convenient, it recasts citizens as passive viewers of justice and individual users of public services.
Le mouvement populaire en Algérie: vers une rupture systémique? Sur les racines socio-historiques de la crise algérienne
Authors: Abderrezak Adel
Published: July 2019

El propósito de este artículo no es hacer relación del reciente movimiento popular acontecido en Argelia, ni hacer una cronología de hechos. Tenemos que recontextualizar históricamente este sistema de poder en su dimensión política y económica para poder comprender cómo se puso fin al ciclo de Bouteflika.
Le regard de Dib et Camus sur le paysage algérien
Authors: Leguen Brigitte
Published: July 2019

Mohamed Dib y Albert Camus ambos nacieron en Argelia rodeados por el mismo paisaje. En este artículo analizaremos cómo cada uno percibe el espacio y sus significados.
Genética: um fator de influência na formação da personalidade
Authors: Freitas Dayanne da SIlva , Viana Lucian da Silva , Figueiredo Cunha Carlos Leonardo , Silva Artenira da Silva e , Suarez Mariela Andrea Medeiros
Published: July 2019

Objetiva-se analisar a genética como um fator de influência na formação da personalidade, dando enfoque na interação entre gene e ambiente, e o que revelam os estudos sobre esses e outros fatores. Realizou-se uma pesquisa sistemática em livros, dissertações e revistas eletrônicas, sobre a importância dos fatores genéticos no desenvolvimento da personalidade. Os resultados apontam que as predisposições genéticas podem levar as pessoas a realizar mudanças em seu ambiente, e o ambiente pode levar os genes a se tornarem atuantes ou não. Em vista disso, a maior parte dos psicólogos hoje em dia aceita uma visão interacionista, sugerindo que as influências genéticas e ambientais estão ligadas a determinação da forma final da personalidade. A personalidade de cada indivíduo representa assim, uma combinação regular de fatores genéticos e de experiências de vida. É necessária uma profunda reflexão quanto ao modo como esses e outros fatores interagem. Os estudos sobre a temática ainda não foram esgotados, mas esta é uma característica da ciência, e, é provável que os dados que estão em falta, continuem sendo inseridos à medida que as pesquisas avançarem.
A política da AIDS no Brasil: uma revisão da literatura
Authors: Sousa Adelaine Maria de , Lyra Arine , De Araújo Carla Cristiana França , Pontes Juliana Leão , Freire Romero Correia , Pontes Taciana Leão
Published: July 2019

A AIDS é uma doença causada pelo vírus HIV e corresponde ao estágio mais avançado da infecção que ataca o sistema imunológico. É considerada uma pandemia. Não possui um perfil epidemiológico único. Devido à inexistência de uma política pública estruturada pelo Estado visando seu combate surgiram um grande número de ONGs voltadas para a doença no país. A política de enfrentamento ganhou força ao atingir diversos grupos sociais, quando a sociedade civil se mobilizou e garantiu sua priorização, a pressão política e financiamento estável, inclusive o incentivo internacional. Atualmente o Brasil apresenta uma das mais modernas políticas de enfrentamento à AIDS; é referência internacional.
EVALUATION OF UNDERGROUND STRUCTURES SUBJECTED TO SEISMIC LOADS
Authors: Pruška Jan
Published: July 2019

The paper is focused on the evaluation of the effect of earthquakes on underground structures. Free-field analysis is one solution of this task common mainly in engineering tunnelling practice, but it has some rather simplified aspects (e.g. equivalent shear strain is constant). Pseudostatic finite element calculation combines free-field analysis and the advantages of a FEM model. Dynamic effects are introduced in the form of displacements prescribed along the vertical boundaries of the FEM model in a usually static manner. This approach also implies constant material parameters for the geological profile in the horizontal direction, an arbitrary geometry of excavation, soil structure interaction and description of share waves as a time-dependent 1D analysis of the so called free-field column. Moreover, there is shown an example comparing pseudo-static FEM analysis with an analytical method. Finally, the advantages of the pseudo-static FEM method are presented.
Interruption of Medium-Voltage Direct-Currents by Seperation of Contact Elements in Mineral Oil Using an Ultra Fast Electro-Magnetic Actuator
Authors: Jugelt S. , Leu C.
Published: July 2019

The increasing usage of medium-voltage direct-current in upcoming electrical energy grid topologies requests novel solutions for MVDC switching. The interruption of direct-currents is accomplished by enforcing a current zero crossing by adequate means and preventing reignition due to the recovering dc voltage. This paper evaluates the rapid separation of the contact elements in mineral oil leading to a liquid flow around the contact elements and the switching arc. The energy turnover of dielectric liquids interacting with an electric arc is considerably higher leading to heavily increased arc voltages compared to dielectric gases. This paper confirms results of earlier publications and carries them further towards a possible usage in an MVDC switching or protection device. Thus a contact arrangement surrounded by mineral oil in combination with an ultra fast electro-magnetic actuator is introduced and performed measurements are discussed.
Numerical Investigation, Including Experimental Validation, of an Axially Blown, Stable Arc in Argon
Authors: Galletti B. , Kassubek F. , Buffoni M. , Carstensen J. , Stoller P. C.
Published: July 2019

In this work we present the outcome of a numerical validation study conducted with an arc model developed within a computational fluid dynamics (CFD) tool. The numerical investigations were aimed at reproducing the spatially resolved temperature data obtained with an experiment in which an axially symmetric argon arc was established in the observation region. The full absorption spectrum has been computed for argon and then compressed with minimum loss of information to a relatively small set of bands. The latter has been used for solving the radiative transfer equation in a computationally affordable, yet accurate way. The comparison between the arc temperature simulated with the reduced absorption data and the measured one is presented.
Diagnostics of Plasma Pencil Discharge for Chemical Analysis
Authors: Slavíček P. , Hrdlicka A. , Dvorakova M. , Kanicky V.
Published: July 2019

We present diagnostics of plasma pencil discharge as alternative excitation source for analytical chemistry. The plasma pencil is special type of rf plasma nozzle at atmospheric pressure. Through this nozzle flows working gas argon with aerosol. The aerosol sample introduction system employed a double pass Scott spray chamber with a pneumatic concentric nebulizer. The parameters of the plasma were calculated by optical emission spectroscopy.
EFECTO DE DIFERENTES MULCHINGS SOBRE EL CRECIMIENTO DE UNA PLANTACIÓN DE DURAZNEROS (Prunus persicae L.) VARIEDAD OPODEPE EN ZAVALLA, PROVINCIA DE SANTA FE
Authors: FLORES P. , AUSILIO A. , LEONE A. , POGGI D. , QUADRELLI A. , SOLINI I. , LÓPEZ M. , MONTI F. , CATRARO M.
Published: July 2019

El objetivo de esta investigación fue determinar el efecto de mulchings orgánicos e inorgánicos sobre el crecimiento de durazneros var. Opodepe en el sur de la Prov. de Santa Fe. Las variables evaluadas fueron humedad de suelo, pH, conductividad (CE) y crecimiento del cultivo. La humedad del suelo alcanzó los mayores valores en mulching orgánico, no existiendo diferencias significativas con respecto al inorgánico. No se registraron valores de pH que comprometieran el desarrollo de los durazneros. La CE aumentó en el mulching inorgánico, pero con valores no limitantes para el desarrollo del cultivo. Las variables de crecimiento mostraron los mejores resultados en mulching inorgánico. Este manejo asegura un eficiente establecimiento del cultivo porque permite un excelente control de las malezas sin necesidad de recurrir al control químico, ni mecánico, mientras que se recomienda utilizar mulching orgánico recién cuando el monte frutal está establecido.
EFECTOS DE TANINOS CONDENSADOS DE Schinopsis balansae EN LA DIETA DE CABRAS LECHERAS SOBRE PARÁMETROS PRODUCTIVOS
Authors: MARTINEZ G. M. , SUAREZ V. H. , OLMOS L. H. , ALFARO R. J. , ALFARO E. J. , YANES R. P. , OROSCO S. M.
Published: July 2019

La utilización de taninos condensados de quebracho (TCQ) puede resultar beneficiosa, inocua o perjudicial en el comportamiento productivo de los rumiantes. El objetivo del presente trabajo fue el de evaluar los efectos de la inclusión de TCQ al 2% del consumo estimado de materia seca (CMS) en la dieta de cabras lecheras sobre el consumo, la producción y la composición de leche. Se emplearon 16 cabras Saanen en inicio de lactancia. El periodo experimental fue de 11 semanas. Los tratamientos fueron: sin suministro de taninos condensados de quebracho (STQ) y con suministro (CTQ). El diseño experimental fue un diseño completamente al azar con mediciones repetidas en el tiempo. El análisis estadístico de los datos se realizó a través del programa InfoStat versión 2017p. No se registraron diferencias estadísticamente significativas para ninguno de los parámetros productivos considerados. Por lo que es posible concluir que la inclusión de TCQ en las condiciones y dosis empleada no reportó beneficio alguno en los parámetros evaluados.
Activation of Small Organic Molecules on Ti2+-Rich TiO2 Surfaces: Deoxygenation vs. C–C Coupling
Authors: Kräuter Jessica , Mohrhusen Lars , Thiedemann Tim , Willms Michael , Al-Shamery Katharina
Published: July 2019

Rutile TiO2 is an important model system for understanding the adsorption and conversion of molecules on transition metal oxide catalysts. In the last decades, point defects, such as oxygen vacancies and Ti3+ interstitials, exhibited an important influence on the reaction of oxygen and oxygen-containing molecules on titania surfaces. In brief, partially reduced TiO2 containing a significant amount of Ti3+ is often more active for the conversion of such molecules. In this study, we investigate an even higher reduced surface prepared by argon ion bombardment of a rutile TiO2 (110) single crystal. By X-ray photoelectron spectroscopy we show that, besides Ti4+, this surface is almost equally dominated by Ti3+ and Ti2+. To probe the reactivity of these highly reduced surfaces, we have adsorbed two different classes of oxygen-containing molecules and utilized temperature programmed reaction spectroscopy to investigate the conversion. While alcohols (in this case methanol) already show a defect-dependent partial conversion in a deoxygenation reaction on the (stochiometric or slightly reduced) rutile TiO2 (110) surface, ketones (e.g. acetone) are usually not converted on the rutile TiO2 (110) surface independent on the bulk defect density. Here, we present a nearly full conversion for both molecules via deoxygenation reactions and reductive C–C coupling, forming different hydrocarbons at different temperatures between 375 K and 640 K on the sputtered Ti2+ rich surface.
Impact of Two High-Volume Set Configuration Workouts on Resistance Training Outcomes in Recreationally Trained Men
Authors: Karsten Bettina , Fu Yue (Leon) , Larumbe-Zabala Eneko , Seijo Marco , Naclerio Fernando
Published: July 2019

Karsten, DB, Fu, Y, Larumbe-Zabala, DE, Seijo, DM, and Naclerio, DF. Impact of two high-volume set configuration workouts on resistance training outcomes in recreationally trained men. J Strength Cond Res 35(2S): S136–S143, 2021—This study compared the effects of 2 weekly equalized by volume, loading zone and frequency resistance training designs using repetition to failure (RTF) or not to failure (NTF), on body composition, strength, and mechanical power. Based on individual baseline maximal strength, 18 recreationally resistance-trained men were pair-matched and consequently randomly assigned to an RTF (n = 9) or an NTF (n = 9) protocol. Subjects trained for 6 weeks using 2 different routines performed once per week (2 workouts per week). The RTF protocol comprised 4 sets of 10 repetitions per exercise with 2-minute rest and the NTF involved 8 sets of 5 repetitions per exercise with 1-minute rest. Subjects were tested pre- and post-intervention for maximal strength, upper- and lower-body power, fat-free mass, limb circumferences, and muscle thickness. Compared to baseline, both groups improved (p < 0.01) the maximal loads lifted in the bench press (RTF +9.44 ± 3.00 kg; NTF +7.22 ± 4.41 kg) and the squat (RTF +9.44 ± 4.64 kg; NTF +11.1 ± 10.33 kg) exercises, but only the NTF group increased (p < 0.05) upper-body power (+15.73 ± 12.59 W). Conversely, only the RTF group showed significant (p < 0.05) increase of the elbow flexors (+3.44 ± 5.11 mm) and vastus medialis (+3.28 ± 2.32 mm) thickness, whereas both groups enhanced anterior deltoid thickness (RTF +1.84 ± 1.68 mm, p < 0.05; NTF +2.76 ± 2.63 mm, p < 0.01). Although both training strategies improved strength, the RTF group elicited superior hypertrophic outcomes, whereas the NTF protocol resulted in more favorable improvements for upper-body power.
Scientific Basis for Eccentric Quasi-Isometric Resistance Training: A Narrative Review
Authors: Oranchuk Dustin J. , Storey Adam G. , Nelson André R. , Cronin John B.
Published: July 2019

Oranchuk, DJ, Storey, AG, Nelson, AR, and Cronin, JB. The scientific basis for eccentric quasi-isometric resistance training: A narrative review.J Strength Cond Res33(10): 2846–2859, 2019—Eccentric quasi-isometric (EQI) resistance training involves holding a submaximal, yielding isometric contraction until fatigue causes muscle lengthening and then maximally resisting through a range of motion. Practitioners contend that EQI contractions are a powerful tool for the development of several physical qualities important to health and sports performance. In addition, several sports involve regular quasi-isometric contractions for optimal performance. Therefore, the primary objective of this review was to synthesize and critically analyze relevant biological, physiological, and biomechanical research and develop a rationale for the value of EQI training. In addition, this review offers potential practical applications and highlights future areas of research. Although there is a paucity of research investigating EQIs, the literature on responses to traditional contraction types is vast. Based on the relevant literature, EQIs may provide a practical means of increasing total volume, metabolite build-up, and hormonal signaling factors while safely enduring large quantities of mechanical tension with low levels of peak torque. Conversely, EQI contractions likely hold little neuromuscular specificity to high velocity or power movements. Therefore, EQI training seems to be effective for improving musculotendinous morphological and performance variables with low injury risk. Although speculative due to the limited specific literature, available evidence suggests a case for future experimentation.
Three DNA Polymorphisms Previously Identified as Markers for Handgrip Strength Are Associated With Strength in Weightlifters and Muscle Fiber Hypertrophy
Authors: Grishina Elina E. , Zmijewski Piotr , Semenova Ekaterina A. , Cięszczyk Paweł , Humińska-Lisowska Kinga , Michałowska-Sawczyn Monika , Maculewicz Ewelina , Crewther Blair , Orysiak Joanna , Kostryukova Elena S. , Kulemin Nickolay A. , Borisov Oleg V. , Khabibova Sofya A. , Larin Andrey K. , Pavlenko Alexander V. , Lyubaeva Ekaterina V. , Popov Daniil V. , Lysenko Evgeny A. , Vepkhvadze Tatiana F. , Lednev Egor M. , Bondareva Elvira A. , Erskine Robert M. , Generozov Edward V. , Ahmetov Ildus I.
Published: July 2019

Grishina, EE, Zmijewski, P, Semenova, EA, Cięszczyk, P, Humińska-Lisowska, K, Michałowska-Sawczyn, M, Maculewicz, E, Crewther, B, Orysiak, J, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, EA, Vepkhvadze, TF, Lednev, EM, Bondareva, EA, Erskine, RM, Generozov, EV, and Ahmetov, II. Three DNA polymorphisms previously identified as markers for handgrip strength are associated with strength in weightlifters and muscle fiber hypertrophy. J Strength Cond Res 33(10): 2602–2607, 2019—Muscle strength is a highly heritable trait. So far, 196 single nucleotide polymorphisms (SNPs) associated with handgrip strength have been identified in 3 genome-wide association studies. The aim of our study was to validate the association of 35 SNPs with strength of elite Russian weightlifters and replicate the study in Polish weightlifters. Genotyping was performed using micro-array analysis or real-time polymerase chain reaction. We found that the rs12055409 G-allele near the MLN gene (p = 0.004), the rs4626333 G-allele near the ZNF608 gene (p = 0.0338), and the rs2273555 A-allele in the GBF1 gene (p = 0.0099) were associated with greater competition results (total lifts in snatch and clean and jerk adjusted for sex and weight) in 53 elite Russian weightlifters. In the replication study of 76 sub-elite Polish weightlifters, rs4626333 GG homozygotes demonstrated greater competition results (p = 0.0155) and relative muscle mass (p = 0.046), adjusted for sex, weight, and age, compared with carriers of the A-allele. In the following studies, we tested the hypotheses that these SNPs would be associated with skeletal muscle hypertrophy and handgrip strength. We found that the number of strength-associated alleles was positively associated with fast-twitch muscle fiber cross-sectional area in the independent cohort of 20 male power athletes (p = 0.021) and with handgrip strength in 87 physically active individuals (p = 0.015). In conclusion, by replicating previous findings in 4 independent studies, we demonstrate that the rs12055409 G-, rs4626333 G-, and rs2273555 A-alleles are associated with higher levels of strength, muscle mass, and muscle fiber size.
Acute Effects of “Composite” Training on Neuromuscular and Fast Stretch-Shortening Cycle Drop Jump Performance in Hurling Players
Authors: Byrne Paul J. , Moody Jeremy A. , Cooper Stephen-Mark , Kinsella Sharon
Published: July 2019

Byrne, PJ, Moody, JA, Cooper, SM, and Kinsella, S. Acute effects of “composite” training on neuromuscular and fast stretch-shortening cycle drop jump performance in hurling players. J Strength Cond Res 35(12): 3474–3481, 2021—“Composite” training is a term developed by the authors and defined as the combination of a plyometric exercise with an explosive activity such as a sprint run, performed as a “combined repetition”/session. The purposes of this study were to investigate the acute effect of a “composite” training session on neuromuscular and fast stretch-shortening cycle bounce drop jumps (BDJs) in hurling players' immediately, after session, and after 7 days of recovery. Eight hurling players first completed a drop jump test to identify individual BDJ drop height, followed 72 hours later with a single “composite” training session. Three repetition maximum (3RM) back squat strength, BDJ, countermovement jump (CMJ), and sprint performance testing were performed 10 minutes before and immediately after session and 7 days after session. An analysis of variance reported a significant decrease in CMJ measures (height, velocity, and eccentric rate of force development) and sprint performance from presession to postsession (p ≤ 0.05). Moreover, a significant increase was evident for CMJ performance (height and power), sprint performance (5 and 20 m), 3RM back squat strength, and BDJ performance (reactive strength index and height) from postsession to post–7-day recovery (p ≤ 0.05). Pairwise comparisons indicated that absolute and relative 3RM strength significantly increased from presession to post–7 days (absolute 3RM: p = 0.0001; relative 3RM: p = 0.01). The findings indicate that “composite” training results in an immediate decline in CMJ measures after session possibly due to acute muscle fatigue, and supercompensation augments maximum lower-limb strength after 7 days of recovery.
Evaluation of Cement Paste Cylinder Preparation Methods for Mechanical Property Measurements
Authors: Hansen Bradley S. , Howard Isaac L.
Published: July 2019

Testing cement paste (CP) cylinders for thermal, mechanical, or both properties has gained some recent traction, with thermal methods (e.g., the recently completed ASTM C1753) being more developed than mechanical property assessments. CP contains water, cementitious materials, and sometimes admixtures; no sand or aggregates. Currently there is no standard production method for CP cylinders. As such, the objectives of this article are to assess the variability of CP mechanical properties from multiple methods and then recommend a CP cylinder preparation method considering overall properties and variability. The recommended method prepares specimen tops in a similar manner to one common method for concrete cylinders (i.e., strike off the specimen top). The rationale for selecting this approach was this method produced essentially the same average compressive strength as existing approaches but with slightly less variability and no extra effort. The proposed method had compressive strength coefficients of variations of 17 % or less when specimens were tested within 0.5 hours of removal from moist curing. The proposed method is able to produce specimens with density and moisture content coefficients of variation of less than 1 %.
Engaging Young Men in the HIV Prevention and Care Continua: Experiences From Young Men of Color Who Have Sex With Men
Authors: Kubicek Katrina , Beyer William J. , Wong Carolyn F. , Kipke Michele D.
Published: July 2019

Sexual minority individuals experience barriers to receiving equitable health care. Research also indicates that young men who have sex with men (YMSM), particularly young men of color, have limited engagement in the HIV care continuum and there are significant disparities across the continuum. This study aims to uncover how providers can engage YMSM of color in all forms of care, including primary care and HIV prevention through an HIV prevention continuum. This qualitative study reports data from the Healthy Young Men's Cohort Study; a total of 49 YMSM participated in the eight focus groups. This study provides a description of YMSM's overall health concerns, experiences with health care, and under what circumstances YMSM seek care. We then present a model describing the salient characteristics of a HIV prevention continuum for YMSM of color and provide clear areas for education, intervention, and policy change to support better overall health for YMSM of color.
p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model
Authors: Martínez-Mármol Ramón , Mohannak Nika , Qian Lei , Wang Tong , Gormal Rachel S. , Ruitenberg Marc J. , Vanhaesebroeck Bart , Coulson Elizabeth J. , Meunier Frédéric A.
Published: July 2019

Alzheimer's disease (AD) is associated with the cleavage of the amyloid precursor protein (APP) to produce the toxic amyloid-β (Aβ) peptide. Accumulation of Aβ, together with the concomitant inflammatory response, ultimately leads to neuronal death and cognitive decline. Despite AD progression being underpinned by both neuronal and immunological components, therapeutic strategies based on dual targeting of these systems remains unexplored. Here, we report that inactivation of the p110δ isoform of phosphoinositide 3-kinase (PI3K) reduces anterograde axonal trafficking of APP in hippocampal neurons and dampens secretion of the inflammatory cytokine tumor necrosis factor-alpha by microglial cells in the familial AD APPswe/PS1ΔE9(APP/PS1) mouse model. Moreover, APP/PS1 mice with kinase-inactive PI3Kδ (δD910A) had reduced Aβ peptides levels and plaques in the brain and an abrogated inflammatory response compared with APP/PS1 littermates. Mechanistic investigations reveal that PI3Kδ inhibition decreases the axonal transport of APP by eliciting the formation of highly elongated tubular-shaped APP-containing carriers, reducing the levels of secreted Aβ peptide. Importantly, APP/PS1/δD910Amice exhibited no spatial learning or memory deficits. Our data highlight inhibition of PI3Kδ as a new approach to protect against AD pathology due to its dual action of dampening microglial-dependent neuroinflammation and reducing plaque burden by inhibition of neuronal APP trafficking and processing.

SIGNIFICANCE STATEMENTDuring Alzheimer's disease (AD), the accumulation of the toxic amyloid-β (Aβ) peptide in plaques is associated with a chronic excessive inflammatory response. Uncovering new drug targets that simultaneously reduce both Aβ plaque load and neuroinflammation holds therapeutic promise. Using a combination of genetic and pharmacological approaches, we found that the p110δ isoform of phosphoinositide 3-kinase (PI3K) is involved in anterograde trafficking of the amyloid precursor protein in neurons and in the secretion of tumor necrosis factor-alpha from microglial cells. Genetic inactivation of PI3Kδ reduces Aβ plaque deposition and abrogates the inflammatory response, resulting in a complete rescue of the life span and spatial memory performance. We conclude that inhibiting PI3Kδ represents a novel therapeutic approach to ameliorate AD pathology by dampening plaque accumulation and microglial-dependent neuroinflammation.
Performing White and Fine
Authors: Thomas Quincy
Published: July 2019

In this article I explore the ways my identity was shaped while I attended Bob Jones University in Greenville, South Carolina. Bob Jones University has been praised by some for its fundamentalist stands, its focus on Christian education, and its tireless pursuit of excellence. Unfortunately for me, a young African American man, this was also a place where I experienced hurtful jokes, slurs, institutional racism, and racist microaggressions. I argue that the aftereffects of these events are analogous to the effects experienced by survivors of posttraumatic stress disorder and sexual abuse victims. I call upon my memories of Bob Jones University and how my time at the university prompted myriad feelings that ran the gamut from painful to poignant.
Monomethylfumarate protects against ovariectomy-related changes in body composition
Authors: Bollag Anna E , Guo Tianyang , Ding Ke-Hong , Choudhary Vivek , Chen Xunsheng , Zhong Qing , Xu Jianrui , Yu Kanglun , Awad Mohamed E , Elsalanty Mohammed , Johnson Maribeth H , McGee-Lawrence Meghan E , Bollag Wendy B , Isales Carlos M
Published: July 2019

Osteoporosis, low bone mass that increases fracture susceptibility, affects approximately 75 million individuals in the United States, Europe and Japan, with the number of osteoporotic fractures expected to increase by more than three-fold over the next 50 years. Bone mass declines with age, although the mechanisms for this decrease are unclear. Aging enhances production of reactive oxygen species, which can affect bone formation and breakdown. The multiple sclerosis drug Tecfidera contains dimethylfumarate, which is rapidly metabolized to monomethylfumarate (MMF); MMF is thought to function through nuclear factor erythroid-derived-2-like-2 (NRF2), a transcription factor activated by oxidative stress which induces the expression of endogenous anti-oxidant systems. We hypothesized that MMF-elicited increases in anti-oxidants would inhibit osteopenia induced by ovariectomy, as a model of aging-related osteoporosis and high oxidative stress. We demonstrated that MMF activated NRF2 and induced anti-oxidant NRF2 target gene expression in bone marrow-derived mesenchymal stem cells. Sham-operated or ovariectomized adult female mice were fed chow with or without MMF and various parameters were monitored. Ovariectomy produced the expected effects, decreasing bone mineral density and increasing body weight, fat mass, bone marrow adiposity and serum receptor activator of nuclear factor-kappa-B ligand (RANKL) levels. MMF decreased fat but not lean mass. MMF improved trabecular bone microarchitecture after adjustment for body weight, although the unadjusted data showed few differences; MMF also tended to increase adjusted cortical bone and to reduce bone marrow adiposity and serum RANKL levels. Because these results suggest the possibility that MMF might be beneficial for bone, further investigation seems warranted.
Мудрість як форма інтелектуальної зрілості
Authors: Міщиха Лариса
Published: July 2019

У статті здійснено теоретичний аналіз дефініції «мудрість»; розкривається її зміс­тово-смислове наповнення. Мудрість розглядається автором як інтелектуально-мо­раль­на особистісна складова. Піднімається проблема співвідношення понять «розум­ність» – «мудрість».

На основі емпіричного дослідження здійснено порівняльний аналіз інтерпретацій вищезгаданого поняття між різними віковими категоріями осіб, зокрема, майбутніми психологами (студентами) та людьми старшого віку.
Прояви макіавеллізму в міжособистісній взаємодії студентської молоді
Authors: Вітюк Надія , Вітюк Святослав
Published: July 2019

У статті репрезентовано результати проведеного авторами теоретичного та емпіричного дослідження проблеми макіавеллізму. Розкрито зміст поняття «макіавеллізм», визначено основні маркери макіавеллізму в мотиваційній, когнітивній, емоційній та поведінковій сферах особистості. Подано результати дослідження рівня макіавеллізму студентської молоді, проаналізовано прояви макіавеллізму в міжособистісних стосунках студентів, розглянуто особистісні та соціальні на­слід­ки їх маніпулятивної поведінки.
Гендерна толерантність як соціально-психологічний феномен
Authors: Демчина Ольга
Published: July 2019

У статті проаналізовано основні теоретико-методологічні підходи науковців щодо розуміння феномену толерантності та його складників. Висвітлено поняття «гендеру» у соціально-конструктивістському трактуванні, на основі якого сформовано та проана­лі­зовано поняття «гендерної толерантності». Уточнено зміст поняття «гендерна толе­рант­ність» як особистісного утворення і виділено характеристики, які її утворюють. Про­ведено теоретичний аналіз досліджень гендерної толерантності у соціально-психо­ло­гічному контексті, визначено ймовірні моделі гендерної толерантності та сформульо­вано принципи толерантності у міжособистісних відносинах.
Genome Size Evolution Differs BetweenDrosophilaSubgenera with Striking Differences in Male and Female Genome Size inSophophora
Authors: Hjelmen Carl E , Blackmon Heath , Holmes V Renee , Burrus Crystal G , Johnston J Spencer
Published: July 2019

Genome size varies across the tree of life, with no clear correlation to organismal complexity or coding sequence, but with differences in non-coding regions. Phylogenetic methods have recently been incorporated to further disentangle this enigma, yet most of these studies have focused on widely diverged species. Few have compared patterns of genome size change in closely related species with known structural differences in the genome. As a consequence, the relationship between genome size and differences in chromosome number or inter-sexual differences attributed to XY systems are largely unstudied. We hypothesize that structural differences associated with chromosome number and X-Y chromosome differentiation, should result in differing rates and patterns of genome size change. In this study, we utilize the subgenera within the Drosophila to ask if patterns and rates of genome size change differ between closely related species with differences in chromosome numbers and states of the XY system. Genome sizes for males and females of 152 species are used to answer these questions (with 92 newly added or updated estimates). While we find no relationship between chromosome number and genome size or chromosome number and inter-sexual differences in genome size, we find evidence for differing patterns of genome size change between the subgenera, and increasing rates of change throughout time. Estimated shifts in rates of change in sex differences in genome size occur more often in Sophophora and correspond to known neo-sex events.
The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans
Authors: Lee Hanee , Kang Junsu , Ahn Soungyub , Lee Junho
Published: July 2019

Although multiple determinants for establishing polarity in membranes of epithelial cells have been identified, the mechanism for maintaining apicobasal polarity is not fully understood. Here, we show that the conserved Hippo kinase pathway plays a role in the maintenance of apicobasal polarity in the developing intestine of Caenorhabditis elegans. We screened suppressors of the mutation in wts-1—the gene that encodes the LATS kinase homolog, deficiency of which leads to disturbance of the apicobasal polarity of the intestinal cells and to eventual death of the organism. We identified several alleles of yap-1 and egl-44 that suppress the effects of this mutation. yap-1 encodes a homolog of YAP/Yki, and egl-44 encodes a homolog of TEAD/Sd. WTS-1 bound directly to YAP-1 and inhibited its nuclear accumulation in intestinal cells. We also found that NFM-1, which is a homolog of NF2/Merlin, functioned in the same genetic pathway as WTS-1 to regulate YAP-1 to maintain cellular polarity. Transcriptome analysis identified several target candidates of the YAP-1-EGL-44 complex including TAT-2, which encodes a putative P-type ATPase. In summary, we have delineated the conserved Hippo pathway in C. elegans consisting of NFM-1-WTS-1-YAP-1-EGL-44 and proved that the proper regulation of YAP-1 by upstream NFM-1 and WTS-1 is essential for maintenance of apicobasal membrane identities of the growing intestine.
Improving Information Sharing for Youth in Foster Care
Authors: Greiner Mary V. , Beal Sarah J. , Dexheimer Judith W. , Divekar Parth , Patel Vikash , Hall Eric S.
Published: July 2019

There are ∼443 000 children in child protective custody (ie, foster care) in the United States. Children in protective custody have more medical, behavioral, and developmental problems that require health care services than the general population. These health problems are compounded by poor information exchange impeding care coordination. Health care providers often do not know which of their patients are in protective custody and are not privy to the critical social history collected by child protective services, including placement history and maltreatment history. Meanwhile, the custodial child protection agency and designated caregivers (ie, foster caregivers and kinship providers) often lack vital elements of the health history of children in their care, which can result in poor health care delivery such as medication lapses, immunization delay, and poor chronic disease management. In this case study, we address this critical component of health care delivery for a vulnerable population by describing a process of developing an information sharing system between health care and child welfare organizations in collaboration with child protection community partners. Lessons learned include recommended steps for improved information sharing: (1) develop shared community vision, (2) determine shareable information components, (3) implement and analyze information sharing approaches, and (4) evaluate information sharing efforts. A successful example of advocating for improvement of information sharing for youth in protective custody is explored to highlight these steps. In collaboration with child protective services, pediatricians can improve information sharing to impact both health care delivery and child protection outcomes.
Cultivating Research Skills During Clinical Training to Promote Pediatric-Scientist Development
Authors: Hurst Jillian H. , Barrett Katherine J. , Kelly Matthew S. , Staples Betty B. , McGann Kathleen A. , Cunningham Coleen K. , Reed Ann M. , Gbadegesin Rasheed A. , Permar Sallie R.
Published: July 2019

Physician-scientists represent a critical component of the biomedical and health research workforce. However, the proportion of physicians who spend a significant amount of effort on scientific research has declined over the past 40 years. This trend has been particularly noticeable in pediatrics despite recent scientific work revealing that early life influences, exposures, and health status play a significant role in lifelong health and disease. To address this problem, the Duke University Department of Pediatrics developed the Duke Pediatric Research Scholars Program for Physician-Scientist Development (DPRS). The DPRS is focused on research training during pediatric residency and fellowship. We aim to provide sufficient research exposure and support to help scholars develop a research niche and scholarly products as well as identify the career pathways that will enable them to achieve their research goals. Herein, we describe the DPRS’s organizational structure, core components, recruitment strategies, and initial results, and we discuss implementation challenges and solutions. Additionally, we detail the program’s integration with the department’s residency and fellowship training programs (with particular reference to the challenges of integrating research into small- to medium-sized residency programs) and describe the development and integration of related initiatives across Duke University School of Medicine. The program served as the basis for 2 successful National Institutes of Health Stimulating Access to Research in Residency (R38) applications, and we hope it will serve as a model to integrate formalized research training for residents and fellows who wish to pursue research careers in academic medicine.
Making psychedelics into medicines: The politics and paradoxes of medicalization
Authors: Noorani Tehseen
Published: July 2019

This commentary considers efforts to turn psychedelics into medications that can be administered through healthcare systems as examples of “medicalization.” I draw on ethnographic research both inside and outside of university-based clinical trials from 2014 to date, together with analogous examples from psychiatry and drug research and development. Rather than taking a normative stance on medicalization, I situate it in a wider political, economic, and cultural context to better understand its logics and effects. I begin by suggesting the resurgence of psychedelic science has been concerned with medicalization from the outset, recently prompting a crisis in the “psychedelics community” over its self-identity and values. Next, against the confident public messaging surrounding psychedelics, I consider how attempts to scale up and market psychedelic-assisted therapy could end up undermining the safety and efficacy of the therapy itself. I then outline the movements to decriminalize, legalize, and minimize the harms and risks of using psychedelics in their currently illicit therapeutic and recreational modalities. Finally, I explore how working toward psychedelic medicalization over the coming years may influence the movements toward decriminalizing and legalizing psychedelics use, focusing on the underarticulated ways in which medicalization may disregard or even hinder, rather than help, decriminalization and legalization efforts. I call attention to how the cost of gaining approval for therapies incentivizes the development of diluted-yet-profitable forms of psychedelic-assisted treatments, and how frameworks developed for “proper use” demarcate what counts as “abuse” and enable those with newly sanctioned access to psychedelics to condemn afresh their illicit use.
DIGITAL CUSTOMER ENGAGEMENT DIMENSIONS IN DIGITAL TRANSFORMATION AND A FRAMEWORK SUGGESTION FOR RETAIL BANKING
Authors: AKGÜL Yakup , RUBACI Hadi
Published: July 2019

Although there are many implications regarding customer experience, retention, loyalty etc. the comprehensive approach for digital customer engagement still needs more attention. Digital platforms leave customer alone with his or her community without bank’s involvement. This approach requires a good business understanding that will match the CE network with digital capabilities. Since the customer engagement is one of the four pillars of digital transformation, retail banks should start to measure digital CE score based on each customer group as a holistic approach to cover full cycle.Transactional customers who have low relational and emotional exchange will switch the brand easily since they have big price and satisfaction sensitivity. Delighted customers have a good commitment level but requiring interaction and relationship with the brand. Loyal customer’s commitment level changes easily based on market conditions, however they have a good relationship level with the brand. Fans have good relationship and commitment level with the brand. They advocate for the brand easily.Keywords: Customer Engagement, Digital Customer Engagement, Digital Transformation, Customer Relationship ManagementJEL classification: M15, M31, O32
ANALYSIS OF THE RELATIONSHIP BETWEEN INFLATION, BUDGET DEFICIT AND MONEY SUPPLY IN TURKEY BY ARDL APPROACH 1980-2017
Authors: ERDİL ŞAHİN Begüm
Published: July 2019

Inflation is considered as a monetary phenomenon and its increase is linked with money supply according to the Monetarist view. In other words, the increase in budget deficits leads to an increase in money supply and as a result, inflation rates rise. Inflation is based on fiscal policies rather than monetary policies according to Price Level Fiscal Theory. Accordingly, increasing budget deficits leads to increases in loans, thus causes interest rates to rise and consequently inflation rises as money supply increases. In this study, the relationship between inflation, budget deficit and money supply in Turkey is analyzed using the ARDL bounds testing approach for the 1980-2017 period. According to the empirical results, there was a positive and significant relationship between inflation and budget deficit both in the long and short term.Keywords: Inflation, Deficit, Money Supply, Turkey, ARDLJel Codes: E31, E51, E52