bluuebunny/crossref_metadata_2025 huggingface dataset:
Synergistic Growth Inhibitory Effects of Eryngium kotschyi Extracts with
Conventional Cytotoxic Agents: Cisplatin and Doxorubicin against
Human Endometrium Cancer Cells
Authors: Karaboğa Arslan Ayşe Kübra , Paşayeva Leyla , Esen Merve Ayşe , Tugay Osman
Published: August 2021

Background:

Endometrial cancer is one of the most common types of cancer. For this reason,
various studies have been carried out on its treatment and the effects of natural products on this
disease.

Objective:

This study aimed to examine the growth inhibitory effects of Eryngium kotschyi Boiss. ethyl
acetate [EKE] and butanol [EKB] obtained from the main methanol [EKM] extract from the aerial parts
on human endometrium carcinoma [RL95-2] cells and their synergistic effect with cisplatin or doxorubicin.

Methods:

RL95-2 cells were treated with E. kotschyi extracts either alone or in combination with cisplatin
or doxorubicin. The effects on cell growth were determined using the MTT assay and real-time cell
analysis xCELLigence.

Results:

The extracts demonstrated growth inhibitory activity, with a certain degree of selectivity
against the RL95-2 cell line. Synergistic effects of EKE/cisplatin or doxorubicin at different concentration
levels were demonstrated in RL95-2 cells. In some instances, the EKE/doxorubicin combinations
resulted in antagonistic effects. The reduction level of cell viability was different and specific to each
combination for the RL95-2 cell line.

Conclusion:

The growth inhibitory activity of cisplatin or doxorubicin, as a single agent, may be modified
by combinations of the extracts and be synergistically enhanced in some cases. A significant synergistic
effect of EKE on the RL95-2 cell line with cisplatin and doxorubicin was observed. This cytotoxic
effect can be investigated in terms of molecular mechanisms. This study is the first of its kind in the
literature. The mechanisms involved in this interaction between chemotherapeutic drugs and plant extracts
remain unclear and should be further evaluated.
Cytotoxic and Anti-proliferative Effects of Moringa oleifera Lam. on HeLa Cells
Authors: Govender Krishnambal , Moodley Indres , Parboosing Raveen
Published: August 2021

Background:

The aim of the study was to determine the mechanism of Moringa oleifera-induced apoptosis in HeLa cells. HeLa cells over-express cyclin E and cyclin B1, abrogate G0-G1 and G2-M cell cycle arrest, promoting tumorigenesis. Cyclin E, cyclin B1, E2F1 and telomerase expression, and caspase-3 and -7 activation were assessed after 24-treatment with M. oleifera leaf fractions.

Material and methods:

Apoptosis through caspase-3 and caspase-7 activation was determined quantitatively by the FAM FLICA™ Caspase-3/7 assay. Cyclin E, cyclin B1 and E2F1 were quantified by flow cytometry. Telomerase was evaluated by Telomeric repeat amplification protocol (TRAP reaction). The effects on colony formation were assessed by seeding treated cells in six-well plates for 7 days under culture conditions. The MTT assay was used to determine cell survival.

Results:

HeLa cells treated for 24 hours with M. oleifera leaf fractions showed dose-dependent cytotoxicity, activation of caspases-3 and -7, down regulation of cyclin E, cyclin B1, E2F1, and inhibition of telomerase expression. Cell cycle analysis of the dead cell population showed G2-M cellcycle arrest.

Conclusion:

M. oleifera leaf fractions triggered apoptosis through the mitochondrial pathway and cell cycle arrest at G2-M phase in HeLa cells after 24-hour treatment, through down regulation of cyclin E and cyclin B1 expression, and caspase-3 and -7 activation. In addition, M. oleifera leaf extract induces senescence in HeLa cells through the down-regulation of telomerase. Colony formation and cell proliferation were inhibited in a dose-dependent manner, corresponding with telomerase inhibition.
Молекулярно-пучковая эпитаксия нитевидных нанокристаллов InGaN на подложках SiC/Si(111) и Si(111): сравнительный анализ
Authors: Гридчин В.О. , Резник Р.Р. , Котляр К.П. , Драгунова А.С. , Крыжановская Н.В. , Серов А.Ю. , Кукушкин С.А. , Цырлин Г.Э.
Published: August 2021

In this work, InGaN nanowires with a high In content were grown, for the first time, on hybrid SiC/Si substrates and compared with InGaN nanowires grown on Si. It was shown that InGaN nanowires on SiC/Si have lower indium content (by about 10%) compared to the nanowires on Si. The results can be beneficial for studying the growth mechanisms of InGaN nanowires and creating optoelectronic devices in the visible spectral range.
Управляемая нейроморфная динамика систем фазовой синхронизации
Authors: Цырульникова Л.А. , Сафин А.Р.
Published: August 2021

We consider the neuromorphic dynamics of a filter-free phase locked loop with a phase modulation of a reference oscillator. The transition from pulsed single-spike dynamics to the bursting dynamics can be easily controlled by changing the depth and frequency of phase modulation, as well as the gain factor along the ring of the phase locked loop. The possibility of implementing neuromorphic calculations of the "OR" type in the scheme of three phase locked loops mutually coupled through a common control circuit is shown. The presented results can be used in the design of hardware-implemented neuromorphic networks with increased frequency stability, resistant to noise influences.
Stimulating the Young Learner’s Visual- Spatial Intelligence Through Geomaze
Authors: Sarainsong Wulan Patria , Sidiq Brwa Aziz , Dita Aprilia Mardiani
Published: August 2021

The urgency of this research is to implement application-based Geomaze game media at Dharma Wanita Persatuan 1 Kindergarten in Gresik Regency. This study aims to determine the development, feasibility and effectiveness of application-based Geomaze game media in stimulating visual-spatial intelligence of children aged 4-5 years. This research uses the type of research development or R&D with the ASSURE model. This study uses the target participants of children aged 4-5 years in TK Dharma Wanita Persatuan 1 Gresik Regency as the main sample for testing the application-based Geomaze game media and also testing conventional products or LKA, children aged 4-5 years in Kusuma Bangsa Kindergarten as instrument validity test. The results showed that the application-based game media Geomaze was more effective than conventional media or LKA in stimulating visual-spatial intelligence of children aged 4-5 years. This study is expected to be able to contribute to stimulating children’s visual-spatial intelligence and learning media during the current Covid-19 pandemic.
Variations in Patients’ Overall Assessment of Their Health Across and Within Disease Groups Using the EQ-5D Questionnaire: Protocol for a Longitudinal Study in the Swedish National Quality Registers
Authors: Teni Fitsum Sebsibe , Rolfson Ola , Devlin Nancy , Parkin David , Nauclér Emma , Burström Kristina ,   The Swedish Quality Register (SWEQR) Study Group
Published: August 2021

Background

EQ-5D is one of the most commonly used questionnaires to measure health-related quality of life. It is included in many of the Swedish National Quality Registers (NQRs). EQ-5D health states are usually summarized using “values” obtained from members of the general public, a majority of whom are healthy. However, an alternative, which remains to be studied in detail, is the potential to use patients’ self-reported overall health on the visual analog scale (VAS) as a means of capturing experience-based perspective.

Objective

The aim of this study is to assess EQ VAS as a valuation method with an experience-based perspective through comparison of its performance across and within patient groups, and with that of the general population in Sweden.

Methods

Data on nearly 700,000 patients from 12 NQRs covering a variety of diseases/conditions and nearly 50,000 individuals from the general population will be analyzed. The EQ-5D-3L data from the 12 registers and EQ-5D-5L data from 2 registers will be used in the analyses. Longitudinal studies of patient-reported outcomes among different patient groups will be conducted in the period from baseline to 1-year follow-up. Descriptive statistics and analyses comparing EQ-5D dimensions and observed self-assessed EQ VAS values across and within patient groups will be performed. Comparisons of the change in health state and observed EQ VAS values at 1-year follow-up will also be undertaken. Regression models will be used to assess whether EQ-5D dimensions predict observed EQ VAS values to investigate patient value sets in each patient group. These will be compared across the patient groups and with the existing Swedish experience-based VAS and time trade-off value sets obtained from the general population.

Results

Data retrieval started in May 2019 and data of patients in the 12 NQRs and from the survey conducted among the general population have been retrieved. Data analysis is ongoing on the retrieved data.

Conclusions

This research project will provide information on the differences across and within patient groups in terms of self-reported health status through EQ VAS and comparison with the general population. The findings of the study will contribute to the literature by exploring the potential of self-assessed EQ VAS values to develop value sets using an experience-based perspective.

Trial Registration

ClinicalTrials.gov NCT04359628; https://clinicaltrials.gov/ct2/show/NCT04359628.

International Registered Report Identifier (IRRID)

DERR1-10.2196/27669
Potential Uses of Blockchain Technology for Outcomes Research on Opioids (Preprint)
Authors: Gonzales Aldren , Smith Scott R , Dullabh Prashila , Hovey Lauren , Heaney-Huls Krysta , Robichaud Meagan , Boodoo Roger
Published: August 2021

UNSTRUCTURED

The scale and severity of the opioid epidemic call for innovative, multipronged solutions. Research and development is key to accelerate the discovery and evaluation of interventions that support pain and substance use disorder management. In parallel, the use and integration of blockchain technology within research networks holds the potential to address some of the unique challenges facing opioid research. This paper discusses the applications of blockchain technology and illustrates potential ways in which it could be applied to strengthen the validity of outcomes research on the opioid epidemic. We reviewed published and gray literature to identify useful applications of blockchain, specifically those that address the challenges faced by opioid research networks and programs. We then convened a panel of experts to discuss the strengths, limitations, and feasibility of each application. Blockchain has the potential to address some of the issues surrounding health data management, including data availability, data sharing and interoperability, and privacy and security. We identified five primary applications of blockchain to opioids: clinical trials and pharmaceutical research, incentivizing data donation and behavior change, secure exchange and management of e-prescriptions, supply chain management, and secondary use of clinical data for research and public health surveillance. The published literature was limited, leading us to rely on gray literature, which was also limited in its discussion of the technical aspects of implementation. The technical expert panel provided additional context and an assessment of feasibility that was lacking in the literature. Research on opioid use and misuse is challenging because of disparate data stored across different systems, data and system interoperability issues, and legal requirements. These areas must be navigated to make data accessible, timely, and useful to researchers. Blockchain technologies have the potential to act as a facilitator in this process, offering a more efficient, secure, and privacy-preserving solution for data exchange. Among the 5 primary applications, we found that clinical trial research, supply chain management, and secondary use of data had the most examples in practice and the potential effectiveness of blockchain. More discussions and studies should focus on addressing technical questions concerning scalability and tackling practical concerns such as cost, standards, and governance around the implementation of blockchain in health care. Policy concerns related to balancing the need for data accessibility that also protects patient privacy and autonomy in revoking consent should also be examined.
Effects of Telemetric Interventions on Maternal and Fetal or Neonatal Outcomes in Gestational Diabetes: Systematic Meta-Review (Preprint)
Authors: Eberle Claudia , Stichling Stefanie
Published: August 2021

BACKGROUND

In 2019, 1 of 6 births was affected by gestational diabetes mellitus (GDM) globally. GDM results in adverse maternal, fetal, and neonatal outcomes in the short and long term, such as pregnancy and birth complications, type 2 diabetes, metabolic syndrome, and cardiovascular disease. In the context of “transgenerational programming,” diabetes mellitus during pregnancy can contribute to “programming” errors and long-term consequences for the child. Therefore, early therapy strategies are required to improve the clinical management of GDM. The interest in digital therapy approaches, such as telemetry, has increased because they are promising, innovative, and sustainable.

OBJECTIVE

This study aimed to assess the current evidence regarding the clinical effectiveness of telemetric interventions in the management of GDM, addressing maternal glycemic control, scheduled and unscheduled visits, satisfaction, diabetes self-efficacy, compliance, maternal complications in pregnancy and childbirth, as well as fetal and neonatal outcomes.

METHODS

Medline via PubMed, Web of Science Core Collection, Embase, Cochrane Library, and CINAHL databases were systematically searched from January 2008 to April 2020. We included randomized controlled trials, systematic reviews, meta-analyses, and clinical trials in English and German. Study quality was assessed using “A MeaSurement Tool to Assess systematic Reviews” and “Effective Public Health Practice Project.”

RESULTS

Our search identified 1116 unique studies. Finally, we included 11 suitable studies (including a total of 563 patients and 2779 patient cases): 4 systematic reviews or meta-analyses (1 of high quality and 3 of moderate quality), 6 randomized controlled trials (2 of high quality and 4 of moderate quality), and 1 low-quality nonrandomized controlled trial. We classified 4 “asynchronous interventions” and 3 “asynchronous and real-time interventions.” Our findings indicate that telemetric therapy clearly improves glycemic control and effectively reduces glycated hemoglobin A1c levels. Furthermore, in 1 study, telemetry proved to be a significant predictor for a better glycemic control (hazard ratio=1.71, 95% CI 1.11-2.65; P=.02), significantly fewer insulin titrations were required (P=.04), and glycemic control was achieved earlier. Telemetric therapy significantly reduced scheduled and unscheduled clinic visits effectively, and women were highly satisfied with the treatment (P<.05). From fetal and neonatal short-term outcomes, some improving tendencies in favor of telemetry were determined. No long-term outcomes were detected.

CONCLUSIONS

Telemetric interventions clearly improved glycemic control, notably glycated hemoglobin A1c levels, and reduced scheduled and unscheduled clinic visits effectively, which reinforces this digital approach in the treatment of GDM.
Clustering of Hypoglycemia Events in Patients With Hyperinsulinism: Extension of the Digital Phenotype Through Retrospective Data Analysis (Preprint)
Authors: Worth Chris , Harper Simon , Salomon-Estebanez Maria , O'Shea Elaine , Nutter Paul W , Dunne Mark J , Banerjee Indraneel
Published: August 2021

BACKGROUND

Hyperinsulinism (HI) due to excess and dysregulated insulin secretion is the most common cause of severe and recurrent hypoglycemia in childhood. High cerebral glucose use in the early hours results in a high risk of hypoglycemia in people with diabetes and carries a significant risk of brain injury. Prevention of hypoglycemia is the cornerstone of the management of HI, but the risk of hypoglycemia at night or the timing of hypoglycemia in children with HI has not been studied; thus, the digital phenotype remains incomplete and management suboptimal.

OBJECTIVE

This study aims to quantify the timing of hypoglycemia in patients with HI to describe glycemic variability and to extend the digital phenotype. This will facilitate future work using computational modeling to enable behavior change and reduce exposure of patients with HI to injurious hypoglycemic events.

METHODS

Patients underwent continuous glucose monitoring (CGM) with a Dexcom G4 or G6 CGM device as part of their clinical assessment for either HI (N=23) or idiopathic ketotic hypoglycemia (IKH; N=24). The CGM data were analyzed for temporal trends. Hypoglycemia was defined as glucose levels <3.5 mmol/L.

RESULTS

A total of 449 hypoglycemic events totaling 15,610 minutes were captured over 237 days from 47 patients (29 males; mean age 70 months, SD 53). The mean length of hypoglycemic events was 35 minutes. There was a clear tendency for hypoglycemia in the early hours (3-7 AM), particularly for patients with HI older than 10 months who experienced hypoglycemia 7.6% (1480/19,370 minutes) of time in this period compared with 2.6% (2405/92,840 minutes) of time outside this period (P<.001). This tendency was less pronounced in patients with HI who were younger than 10 months, patients with a negative genetic test result, and patients with IKH. Despite real-time CGM, there were 42 hypoglycemic events from 13 separate patients with HI lasting >30 minutes.

CONCLUSIONS

This is the first study to have taken the first step in extending the digital phenotype of HI by describing the glycemic trends and identifying the timing of hypoglycemia measured by CGM. We have identified the early hours as a time of high hypoglycemia risk for patients with HI and demonstrated that simple provision of CGM data to patients is not sufficient to eliminate hypoglycemia. Future work in HI should concentrate on the early hours as a period of high risk for hypoglycemia and must target personalized hypoglycemia predictions. Focus must move to the human-computer interaction as an aspect of the digital phenotype that is susceptible to change rather than simple mathematical modeling to produce small improvements in hypoglycemia prediction accuracy.
Telemental Health For Youth With Chronic Illnesses: Systematic Review (Preprint)
Authors: Lau Nancy , Colt Susannah F , Waldbaum Shayna , O'Daffer Alison , Fladeboe Kaitlyn , Yi-Frazier Joyce P , McCauley Elizabeth , Rosenberg Abby R
Published: August 2021

BACKGROUND

Children, adolescents, and young adults with chronic conditions experience difficulties coping with disease-related stressors, comorbid mental health problems, and decreased quality of life. The COVID-19 pandemic has led to a global mental health crisis, and telemental health has necessarily displaced in-person care. However, it remains unknown whether such remote interventions are feasible or efficacious. We aimed to fill this research-practice gap.

OBJECTIVE

In this systematic review, we present a synthesis of studies examining the feasibility and efficacy of telemental health interventions for youth aged ≤25 years with chronic illnesses.

METHODS

PubMed, Embase, Web of Science, PsycInfo, and Cochrane Database of Systematic Reviews were searched from 2008 to 2020. We included experimental, quasiexperimental, and observational studies of telemental health interventions designed for children, adolescents, and young adults aged ≤25 years with chronic illnesses, in which feasibility or efficacy outcomes were measured. Only English-language publications in peer-reviewed journals were included. We excluded studies of interventions for caregivers or health care providers, mental health problems not in the context of a chronic illness, disease and medication management, and prevention programs for healthy individuals.

RESULTS

We screened 2154 unique study records and 109 relevant full-text articles. Twelve studies met the inclusion criteria, and they represented seven unique telemental health interventions. Five of the studies included feasibility outcomes and seven included efficacy outcomes. All but two studies were pilot studies with relatively small sample sizes. Most interventions were based on cognitive behavioral therapy and problem-solving therapy. The subset of studies examining intervention feasibility concluded that telemental health interventions were appropriate, acceptable, and satisfactory to patients and their parents. Technology did not create barriers in access to care. For the subset of efficacy studies, evidence in support of the efficacy of telemental health was mixed. Significant heterogeneity in treatment type, medical diagnoses, and outcomes precluded a meta-analysis.

CONCLUSIONS

The state of the science for telemental health interventions designed for youth with chronic illnesses is in a nascent stage. Early evidence supports the feasibility of telehealth-based delivery of traditional in-person interventions. Few studies have assessed efficacy, and current findings are mixed. Future research should continue to evaluate whether telemental health may serve as a sustainable alternative to in-person care after the COVID pandemic.
Ethical Issues of Digital Twins for Personalized Health Care Service: Preliminary Mapping Study (Preprint)
Authors: Huang Pei-hua , Kim Ki-hun , Schermer Maartje
Published: August 2021

BACKGROUND

The concept of digital twins has great potential for transforming the existing health care system by making it more personalized. As a convergence of health care, artificial intelligence, and information and communication technologies, personalized health care services that are developed under the concept of digital twins raise a myriad of ethical issues. Although some of the ethical issues are known to researchers working on digital health and personalized medicine, currently, there is no comprehensive review that maps the major ethical risks of digital twins for personalized health care services.

OBJECTIVE

This study aims to fill the research gap by identifying the major ethical risks of digital twins for personalized health care services. We first propose a working definition for digital twins for personalized health care services to facilitate future discussions on the ethical issues related to these emerging digital health services. We then develop a process-oriented ethical map to identify the major ethical risks in each of the different data processing phases.

METHODS

We resorted to the literature on eHealth, personalized medicine, precision medicine, and information engineering to identify potential issues and developed a process-oriented ethical map to structure the inquiry in a more systematic way. The ethical map allows us to see how each of the major ethical concerns emerges during the process of transforming raw data into valuable information. Developers of a digital twin for personalized health care service may use this map to identify ethical risks during the development stage in a more systematic way and can proactively address them.

RESULTS

This paper provides a working definition of digital twins for personalized health care services by identifying 3 features that distinguish the new application from other eHealth services. On the basis of the working definition, this paper further layouts 10 major operational problems and the corresponding ethical risks.

CONCLUSIONS

It is challenging to address all the major ethical risks that a digital twin for a personalized health care service might encounter proactively without a conceptual map at hand. The process-oriented ethical map we propose here can assist the developers of digital twins for personalized health care services in analyzing ethical risks in a more systematic manner.
Pengembangan Sistem Deteksi Kantuk Menggunakan Pengklasifikasi Random Forest pada Sinyal Elektrokardiogram
Authors: Nuryani Nuryani , Khoirun Nisak  , Artono Dwijo Sutomo
Published: August 2021

Kantuk merupakan salah satu penyebab utama kecelakaan dalam lalu lintas, industri manufaktur, maupun pada bidang lain. Untuk itu, sistem yang dapat mendeteksi kantuk secara dini merupakan hal yang sangat penting dalam rangka mengurangi angka kecelakaan akibat kantuk. Kantuk dapat dianalisis melalui Heart Rate Variability (HRV) dari sinyal EKG yang menunjukkan perubahan aktivitas saraf otonom. Pengklasifikasi Random Forest diketahui berkinerja sangat baik serta kuat terhadap overfitting. Oleh karena itu, pada makalah ini dikembangkan sistem deteksi kantuk menggunakan sinyal elektrokardiogram (EKG) dan Random Forest. Sistem deteksi kantuk dilatih menggunakan rekaman EKG dari database DROZY yang dilengkapi Karolinska Sleepiness Scale (KSS). Fitur masukan sistem diekstraksi berdasarkan metode ranah waktu dan ranah frekuensi. Tingkat kantuk diklasifikasikan berdasarkan KSS yang disederhanakan menjadi dua kelas, yaitu kantuk dan terjaga. Random Forest divalidasi dengan metode Out-of-Bag (OOB). Efek dari variasi jumlah estimator dan max feature terhadap kinerja sistem dievaluasi. Fitur diurutkan berdasarkan kepentingannya dan dikombinasikan sebagai masukan sistem dengan berbagai panjang segmentasi EKG. Kinerja terbaik sistem deteksi kantuk yaitu rata-rata akurasi 94,61%, sensitivitas 96,67%, dan specificity 91,67%, yang diperoleh dengan segmentasi 40 detik.
Deteksi Myocardial Infarction Menggunakan Fitur Statistik Segmen-ST Elektrokardiogram dan Analisis Diskriminan
Authors: Dewi Cahya Fitri  , Nuryani Nuryani , Anto Satriyo Nugraha
Published: August 2021

Pada makalah ini dipaparkan deteksi myocardial infarction menggunakan fitur rata-rata statistik, yaitu rata-rata, median, dan simpangan baku. Klasifikasi yang digunakan adalah metode analisis diskriminan yang diimplementasikan menggunakan perangkat lunak MATLAB. Sinyal EKG yang didapatkan dari perangkat tersebut kemudian diproses, lalu dilakukan esktaksi fitur. Hasil dari proses ekstraksi tersebut dinormalisasi agar semua data pasien memiliki standar yang sama dalam besaran gelombang amplitudo. Setelah dilakukan normalisasi, data digunakan sebagai masukan analisis diskriminan. Makalah ini mencoba menggunakan fitur rata-rata, median, dan simpangan baku. Eksperimen ini menggunakan lima belas lead, yang terdiri atas dua belas lead konvensional dan tiga lead posterior. Penambahan tiga lead tersebut memberikan keuntungan dalam menentukan hasil kinerja. Akurasi terbaik yang didapatkan adalah 97,73%, yaitu dengan fitur rata-rata. Eksperimen ini mencoba membandingkan fitur rata-rata dan simpangan baku; rata-rata dan median; simpangan baku dan median; serta rata-rata, median, dan simpangan baku. Dari eksperimen gabungan tersebut didapatkan akurasi yang terbaik adalah 98,84%, yaitu pada fitur simpangan baku dan median.
Aspect Category Classification dengan Pendekatan Machine Learning Menggunakan Dataset Bahasa Indonesia
Authors: Syaifulloh Amien Pandega Perdana  , Teguh Bharata Aji  , Ridi Ferdiana
Published: August 2021

Ulasan pelanggan merupakan opini terhadap kualitas barang atau jasa yang dirasakan konsumen. Ulasan pelanggan mengandung informasi yang berguna bagi konsumen maupun penyedia barang atau jasa. Ketersediaan ulasan pelanggan dalam jumlah besar pada website membutuhkan suatu framework untuk mengekstraksi sentimen secara otomatis. Sebuah ulasan pelanggan sering kali mengandung banyak aspek sehingga Aspect Based Sentiment Analysis (ABSA) harus digunakan untuk mengetahui polaritas masing-masing aspek. Salah satu tugas penting dalam ABSA adalah Aspect Category Detection. Metode machine learning untuk Aspect Category Detection sudah banyak dilakukan pada domain berbahasa Inggris, tetapi pada domain bahasa Indonesia masih sedikit. Makalah ini membandingkan kinerja tiga algoritme machine learning, yaitu Naïve Bayes (NB), Support Vector Machine (SVM), dan Random Forest (RF) pada ulasan pelanggan berbahasa Indonesia menggunakan Term Frequency–Inverse Document Frequency (TF-IDF) sebagai term weighting. Hasil menunjukkan bahwa RF memiliki kinerja paling unggul dibandingkan NB dan SVM pada tiga domain yang berbeda, yaitu restoran, hotel, dan e-commerce, dengan nilai f1-score untuk masing-masing domain adalah 84.3%, 85.7%, dan 89,3%.
Fuzzy Logic Implementation for Accurate Electric Car Battery SoC Measurement
Authors: Muhammad Dzaky Ashidqi  , Miftahul Anwar  , Chico Hermanu B.A.  , Agus Ramelan  , Feri Adriyanto
Published: August 2021

Changes in temperature can affect the accuracy of the estimated SoC value based on voltage. In this study, fuzzy logic was implemented to correct the SoC estimation error caused by the influence of temperature. The system acquired data through sensors and then processed it using the Arduino microcontroller. Parameters in the form of voltage, temperature, and current were processed by Arduino with a fuzzy logic program which was uploaded into it and produced the output of the estimated SoC value. From the observations, it was found that the estimated SoC value from this method had better accuracy with a smaller error than the SoC estimation based on voltage alone. Using the RMSE method, the errors calculated in this method in the process of charging and discharging without running were 2.26 and 7.74, while the SoC estimation error based on voltage alone reached 4.88 and 12.8. In the discharging process with a running car, the SoC estimation results using fuzzy logic also showed accurate results. There was only 1% of SoC value increasing pattern during the discharging process, which the value trend should continue to decrease and should not be an increase. In addition, compared to the previous method applied to the same research object, namely the chemical equilibrium constant method, this method also showed more accurate results.
Una aproximación a la planificación en los archivos universitarios de Ecuador
Authors: Pacios Ana R. , Bravo Ramos María José
Published: August 2021

Se presenta un análisis de la situación actual de la técnica de planificación en los archivos universitarios de Ecuador. Con el objetivo de conocer el uso y la utilidad de la planificación en estos archivos se elaboró una encuesta dirigida a las y los directores o responsables de un universo conformado por 58 archivos de las instituciones de educación superior ecuatorianas, tanto públicas como privadas, acreditadas por el Consejo Superior de Ecuador. La encuesta obtuvo una tasa de respuesta de 43 %. El análisis de los resultados de la encuesta muestra la necesidad de llevar a cabo acciones formativas en gestión y planificación de archivos ante la falta de conocimientos para abordar la elaboración de un plan estratégico. Sólo un escaso número de archivos cuenta con planes estratégicos vigentes alineados a los planes institucionales pero, salvo excepciones, no han sido difundidos a través de sus sitios web.
Improved Exponential Dual to Ratio Type Imputation for Missing Data under Two-Phase Sampling
Authors: Singh B. K.
Published: August 2021

Abstract: In this paper, authors have proposed a class of exponential dual to ratio type compromised imputation technique and corresponding point estimator in two-phase sampling design. Two different sampling designs in two-phase sampling are compared under imputed data. The bias and M.S.E. of suggested estimator is derived in the form of population parameters using the concept of large sample approximation. Numerical study is performed over two populations using the expressions of bias and M.S.E. and efficiency compared with existing estimators. Keywords: Missing data, Bias, Mean squared error (M.S.E), Two-phase sampling, SRSWOR, Compromised Imputation (C.I.).
Stress-strain state analysis of the design of full-turning vertical empennage for aero-spacecraft
Authors: Chistyakov Andrey A. , Timoshenko Valery P.
Published: August 2021

In this work, the most rational schemes to designing the skin of a full-turning vertical empennage element (stabilator) have been studied. Skin designing schemes were chosen according to aero-spacecraft operating conditions in the re-entry trajectory. During designing process, the requirements for reusable structures of tourist-class aero-spacecrafts were taken into account, such as: maximum simplicity and endurance of the product. To determine the mechanical loads acting on the keel during its movement in the air, a numerical simulation of the aerodynamic flow-around the stabilator profile at 5 arbitrary points on the flight path was carried out. The parameters used for the analysis are: flight velocity, density and viscosity of the air. Of the 5 obtained fields of dynamic pressure acting on the stabilator, the field that creates the largest distributed load was used as the boundary condition for the analysis of the stress-strain state of the structure. The problem of mechanical loading of the stabilator was solved separately for each of the previously studied structural schemes of the skin. Based on the obtained calculation results the optimal skin structural scheme was chosen by comparing the displacements on the line connecting ribs.
Designing of the blades of aircraft propellers by the finite element method, taking into account the strength of structure
Authors: Agapov Vladimir P. , Aidemirov Kurban R.
Published: August 2021

The blades of contemporary turboprop engines have a complex spatial configuration. They can be classified as shells. Methods for the shells calculation are well known. A number of computer programs have been created on their basis. However, these programs do not take into account the peculiarities associated with the mutual influence of deformations of the blade and the aerodynamic and inertial loads acting on it. The aim of this work is to develop a method of finite element calculation of aircraft propeller blades taking into account aeroelastic effects and to create a computer program on its basis that is available to a wide range of designers and engineers. The finite element method is used in a geometrically nonlinear formulation. As the initial one, the equilibrium equation is used, which includes a complete nonlinear stiffness matrix and takes into account both conservative and non-conservative loads. The blade of one of the serial propellers was calculated. The effect of deformations on the magnitude of the aerodynamic load and, as a result, on the stresses in the design sections was found and analyzed. The proposed technique and the program compiled on its basis can be used in the design of aircraft propeller blades.
Method for determining the optimal parameters of the chain transmission, taking into account the design of the drive chain
Authors: Belousov Yuri V.
Published: August 2021

Goal . Develop the design of the drive plate chain and methods for determining the optimal parameters of the chain transmission. Methods. Analysis of the designs of standard drive bushing and roller chains, as well as the drive plate chain with internal engagement. Determination of ways to increase the durability of these chains and chain gears from the condition of ensuring the wear resistance of their hinges and increasing their technical and economic indicators. Results . The analysis of designs of standard drive bushing-roller chains and drive plate chains with internal gearing is performed. A promising design of the drive plate chain has been developed. The optimization of transmission parameters, both with standard chains, and with the chain proposed by the authors, providing an increase in their durability and efficiency. In this regard, a method has been developed for determining the greatest elongation of standard chain links, as well as the chain developed by the authors, from the condition of wear resistance of their hinges. A method for determining the optimal transmission ratio of these chain gears has also been developed. It is established that the gear ratio of the transmission with the drive plate chain developed by the authors is determined primarily by the accuracy of manufacturing its hinges. With sufficiently precise manufacturing of chain hinge parts, the gear ratio can be significantly increased, up to u=10 and higher. This will allow you to use gears equipped with this chain in drives with a large gear ratio.
EVIDÊNCIAS DA PLASTICIDADE E ATUALIDADE DA DIVISÃO SEXUAL DO TRABALHO A PARTIR DE QUATRO MODALIDADES CONCRETAS
Authors: Briguglio Bianca , Grecco Fabiana Sanches , Lindôso Raquel Oliveira , Lapa Thaís de Souza
Published: August 2021

Neste artigo, partimos de quatro diferentes modalidades concretas de trabalho: na indústria metalúrgica; na indústria de confecções; nas cozinhas de restaurantes; e no trabalho de catação de materiais recicláveis, para evidenciar a divisão sexual do trabalho, conforme as sociólogas do trabalho, feministas materialistas, Helena Hirata e Danièle Kergoat, a compreendem: como expressão da base material das relações de gênero na sociedade capitalista, regida pelos princípios de separação e de hierarquia, que organizam a divisão social do trabalho entre os gêneros e distribui desigualmente os trabalhos produtivos, domésticos e de cuidados. Com isso, reafirmamos essa concepção de divisão sexual do trabalho como uma chave de leitura teórico metodológica atual, com caráter plástico e comparativo.

ceito.
REFLEXÕES ACERCA DA CONSTITUIÇÃO SEXUADA DO SUJEITO EM DANIÈLE KERGOAT
Authors: De Melo Ávila Maria Betânia , Ferreira Verônica
Published: August 2021

Neste artigo, analisa-se a questão da “mobilização” e a sua relação com a questão da emancipação das mulheres trabalhadoras em Kergoat, isto é, a “passagem do eu para o nós” que, segundo a autora, constitui o “fio condutor que atravessa o conjunto das minhas pesquisas” (KERGOAT, 2018, p. 95). O artigo discute as elaborações de Kergoat baseadas em suas pesquisas empíricas realizadas nos anos 1970, apresenta suas premissas e categorias fundamentais, bem como suas contribuições teórico-políticas para a reflexão contemporânea sobre a constituição das mulheres como sujeito do trabalho e a questão da emancipação considerando as relações sociais de sexo, classe e raça. Como síntese, a incursão no pensamento de Kergoat nos permite pensar a constituição das mulheres como um sujeito no trabalho como uma dimensão que está diretamente relacionada à capacidade das mulheres de se organizarem como coletivo portador de um projeto feminista de igualdade e emancipação.
OS OFÍCIOS NO MUNDO DO TRABALHO CONTEMPORÂNEO
Authors: José Ostronoff Leonardo , Fernando Salla
Published: August 2021

Ofícios e Saberes no Mundo do Trabalho Contemporâneo é uma coletânea organizada por duas professoras experientes na temática do trabalho que conta com a colaboração de diversos autores e do resultado de suas pesquisas. Escapando das tradicionais análises das fábricas, bancos e outros ramos centrais da atividade econômica, o livro discute um objeto pouco explorado nos estudos acadêmicos: o trabalho artesanal. Foram apresentados os seguintes ofícios: telegrafista, alfaiate, costureira, sapateiro, curtumeiro, ceramista, marceneiro, ladrilheiro, amolador de facas, parteira. Uma pluralidade e heterogeneidade que se conecta na resistência ao mundo industrial, tanto na ousadia em não aceitar o controle do tempo taylorista, quanto em continuar realizando um trabalho em que a habilidade manual e a criatividade são exigidas. Dessa maneira, não versa sobre a produção capitalista em larga escala, ao contrário, retrata um aspecto residual a ela, apresentando, através das memórias dos trabalhadores de ofícios artesanais, como resistem à lógica do capital na própria realização do seu trabalho. A coletânea é uma contribuição importante para as reflexões no terreno da Sociologia do Trabalho, abordando desde os aspectos objetivos das atividades laborais, como também os efeitos subjetivos das relações de trabalho no exercício dos ofícios. Os textos desta coletânea fazem um registro das profundas alterações pelas quais muitas ocupações e ofícios abordados foram passando ao longo do tempo; conceito fundamental que percorre o livro todo.
OFENSIVA PATRONAL E VULNERABILIDADE LABORAL
Authors: Colombi Ana Paula Fregnani , Rocha Lemos Patrícia , Gallerani Corrêa Ellen
Published: August 2021

Este artigo analisa os efeitos iniciais da reforma trabalhista de 2017 no ramo de confecções do estado de São Paulo. O universo da pesquisa foi composto por entrevistas semiestruturadas com proprietários de pequenas e grandes empresas da indústria de confecção, um representante da Associação Brasileira da Indústria Têxtil e de Confecção (Abit), dirigentes sindicais do segmento e pela análise de negociações coletivas. Por investigar um fenômeno recente, a pesquisa teve caráter exploratório e buscou identificar as disputas em torno dos principais dispositivos da nova legislação a partir do relato dos empresários e sindicalistas pesquisados. Os resultados apontam para a ampliação da terceirização e do contrato temporário e a configuração de um cenário adverso para a atuação dos sindicatos. Para além de mudanças que reforçam a flexibilização das relações de trabalho, mostra-se que essas alterações contribuem para aprofundar uma prática política e social neoliberal que dissemina a privatização das condutas e a lógica de riscos. Com isso, a relação de assalariamento vai sendo transformada pela queda progressiva de sua dimensão pública.
O MITO DA OUTORGA E A ATUAL LEGISLAÇÃO TRABALHISTA NO BRASIL
Authors: Alves Amauri Cesar , Souza Lima Rocha Marina
Published: August 2021

O presente artigo pretende debater a inconsistência do mito da outorga varguista e demonstrar que a Consolidação das Leis do Trabalho, em 1943, é fruto da pressão dos trabalhadores sobre o capital e o Estado e que esse instrumento normativo vem sendo vilipendiado pelo Estado neoliberal brasileiro, principalmente, a partir de 2017. A construção teórica se dá principalmente em torno da doutrina de Direito do Trabalho e da História, mas conta também com aportes das Ciências Sociais/Sociologia. O objetivo é demonstrar que a legislação trabalhista é fruto de conquistas sociais importantes e que, também por isso, deveria ser protegida. A conclusão é que o Direito do Trabalho cumpriu historicamente uma função de equilíbrio entre capital e trabalho, e sua destruição certamente trará impactos negativos para o sistema, com consequências que poderão ser graves para todos os envolvidos.
YOUNG WORKERS IN FLEXIBLE CAPITALISM
Authors: Fernando Ramalho Martins  , Daniel Wintersberger  , Pires Aline Suelen
Published: August 2021

In this article, we analyse the use of young workers to promote new patterns of work utilisation, illustrating the discussion with an example from Brazilian civil aviation. Data were collected in Brazil during a PhD research. Here we are going to focus on the qualitative element of the study, which draws on 52 interviews with airline and airport workers from a legacy airline (TAM), three low fares companies (GOL, Azul and Webjet) and agencies that provide ground handling services (Swissport and Aero-Park), complemented by three focus groups with a total of 16 workers from low-cost airlines (GOL, Azul, Webjet, Trip). Participants were sampled through local trade union representatives at major airports in São Paulo (Guarulhos and Campinas) and Rio de Janeiro (Galeão and Santos Dumont). Our data shed light on a very dynamic sector that has been making intensive use of a young labour force during a moment of renovation of its competitors, including the low-cost airlines. Thus, our results dwell on the importance of young workers in the implementation of new patterns of labour utilization.
Manifestações Públicas Em Tempos Pandêmicos: Efeitos Da Covid-19 Na Positivação Infraconstitucional Do Direito De Reunião
Authors: Cisneiros Barbosa de Araújo Tiago , Galindo Bruno
Published: August 2021

O artigo aborda as tentativas de regulamentação infraconstitucional do direito de reunião no Brasil, em meio à pandemia de covid-19. Empreende-se a análise da situação, a partir da crise sanitária e das disputas político-ideológicas, com foco na atuação do Legislativo Federal. O objetivo é verificar se os riscos do coronavírus motivaram a apresentação de propostas que estabelecessem mais regras ou limites ao exercício daquela liberdade fundamental. O artigo funda-se em pesquisa qualitativa, utilizando dados públicos, e está dividido em quatro partes. Na primeira, discutem-se conceito, disposições normativas e alcance do direito de reunião. A segunda seção contempla respostas do Executivo e do Judiciário acerca de manifestações no segundo trimestre de 2020, ante a pandemia e o caráter antidemocrático de alguns atos. Na terceira parte, realizam-se levantamento e análise de projetos sobre direito de reunião e suas justificativas, de modo a responder ao problema acerca da influência da covid-19. Por fim, abordam-se as soluções estatais à luz da eficácia e do conteúdo daquele direito, assim como das limitações a sua restrição. Como resultado, refuta-se a hipótese de pesquisa de que a pandemia estimularia tentativas de regulamentação da liberdade de reunião. Em regra, as propostas legislativas têm, como motivação, questões político-ideológicas.
O Ensino Jurídico E O Desenvolvimento Das Habilidades Profissionais Para O Século XXI Na Pandemia De Covid-19: Uma Visão A Partir Dos Docentes Do Estado Do Ceará
Authors: Lins Mateus Rodrigues , Leite Lívia Chaves , Tassigny Mônica Mota
Published: August 2021

Com base em dados coletados a partir de uma amostra de 66 (sessenta e seis) docentes do ensino superior de Direito, este artigo objetiva analisar, no contexto da pandemia do COVID-19, em que medida a migração das aulas presenciais para as aulas síncronas impactaram o ensino jurídico em graduações e pós-graduações de universidades públicas e privadas do Estado do Ceará. A metodologia se deu, principalmente, por meio de pesquisa empírica do tipo survey com a elaboração de formulário no Google Forms, enviadas por e-mail e WhatsApp ao corpo docente de graduações e pós-graduações do curso de Direito de Universidades públicas e privadas do Estado do Ceará. Também se realizou pesquisa bibliográfica com abordagem qualitativa, natureza teórica e caráter descritivo e exploratório. Os resultados à análise dos dados coletados apontam que, embora as aulas fossem preponderantemente presenciais antes da pandemia, as ferramentas virtuais apontam novas possibilidades para que ensino jurídico atinja as expectativas para a formação profissional do século XXI. Concluiu-se, ainda que de forma incipiente, que é possível vislumbrar uma tendência à adaptação e incremento das aulas síncronas no ensino jurídico em graduações e pós-graduações de universidades públicas e privadas do Estado do Ceará.
Racionalidade Neoliberal E Política Pública Urbanística Frente Ao Direito De Participação Popular: Uma Análise Da Adin 0303489-40.2012.8.05.0000
Authors: Nonato Domingos do Nascimento , Raiol Raimundo Wilson Gama , Rebelo Romário Edson da Silva
Published: August 2021

Em um momento sociopolítico muito apropriado, de redefinição da noção prática de representação e soberania popular, reflete-se a respeito da participação da sociedade nas políticas públicas urbanísticas como exercício da referida soberania. Como arena inovadora ou canal de envolvimento da população em geral nas decisões políticas, em vários âmbitos da atuação governamental, a mencionada participação corresponde, na prática, a um mecanismo que serve apenas para validar e legitimar os interesses políticos e econômicos que proliferam nos patamares públicos e privados, inclusive, nos setores hegemônicos, em particular no mercado. Utiliza-se a abordagem qualitativa, a analise bibliográfica e documental, principalmente a ADIn nº 0303489-40.2012.8.05.0000, julgada, no início de 2014, pelo TJ/BA, que decidiu pela inconstitucionalidade parcial e geral de leis do município de Salvador cujo Plano Diretor alteraram, sem garantir ampla e efetiva participação popular. Parte-se da hipótese de que essa participação, decorrente e expressão direta da soberania popular, não se configura automaticamente em arena política apta para oportunizar e consolidar práticas democráticas de gestão pública. A soberania popular funciona como subterfúgio ideológico ou mecanismo artificial que escamoteia a verdadeira face da dominação neoliberal-capitalista traduzida na atuação estatal, que, via de regra, está permeada pelos interesses de setores privados.