bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of PF-543 Derivatives Using Simple Synthetic Methods and Their Biological Effect Analysis for the Development of Anticolorectal Cancer Agents
Authors: Shrestha Jitendra , Lee Joo-Youn , Park Eun-Young , Baek Dong Jae
Published: September 2020

Background:

Sphingolipids, even in extremely low doses, regulate various physiological
functions. Particularly, immune and cancer cells might be controlled by changes in the sphingosine-
1-phosphate (S1P) levels, and S1P has been studied for a long time as a major target for new drug
development. Sphingosine kinase (SK) phosphorylates sphingosine to produce S1P. An increase in
the S1P levels promotes the growth of cancer cells. SK has 2 isoforms, SK1 and SK2, both of which
are involved in the growth of cancer cells.

Objective:

PF-543 has been developed as an SK1 inhibitor and has a non-lipid structure that differs
from those of general SK inhibitors. While PF-543 has a potent SK1 inhibitory effect, and has low
anticancer activity in some types of cancer cells. Therefore, the development of other PF-543 derivatives
is needed.

Methods:

We designed a structurally simplified derivative of PF-543. To primarily demonstrate that
the designed structure was biologically active, 8 derivatives were synthesized by a 2-step method
using the commercial starting material, and their biological activities were evaluated.

Results:

The SK1-inhibitory effects of the synthesized derivatives were not higher than that of PF-
543. However, the anticancer activity and apoptotic effect of the derivatives were similar to those of
PF-543, despite their fabrication from a simple modification of the PF-543 structure. In a docking
study, the derivatives were found to bind SK1 in a form similar to PF-543.

Conclusion:

Our analogs, which are similar to PF-543, showed comparable anticancer activity, indicating
that the synthesized derivatives are structurally more efficient for anticancer activity than
PF-543. Therefore, our study provides important information that may be useful for developing new
anticancer substances that target SK1.
Asymmetric Organocatalyzed Warfarin Synthesis in Aqueous and Nonaqueous Media: A Discussion in the Era of COVID-19 Pandemic
Authors: Mondal Anirban , Bhowmick Kartick C.
Published: September 2020

The recent widespread infection of COVID-19 in the entire world has created a pandemic
situation with a serious health challenge to mankind. Numerous incidents of cardiovascular diseases
were found among COVID-19 patients with a significantly high morbidity rate. Medication
with several anticoagulant or blood thinner drugs are being performed on COVID-19 patients with
atrial fibrillation and cardiovascular ailments to minimize the incidence of death. Warfarin is a
widely used anticoagulant and cardiovascular drug prescribed as its sodium salt. S-Enantiomer is
two to five times more active than R-enantiomer as an anticoagulant. Synthesis of enantiomerically
pure warfarin is thus a rational and extremely important task. Organocatalyzed synthetic strategies
may be considered as important avenues to produce optically pure warfarin in comparison to biocatalysis
and chiral metal complex catalysis. Herein, a comprehensive review of the asymmetric
organocatalyzed synthesis of warfarin catalyzed by diamine based organocatalysts, amino acidbased
organocatalysts, quinine based organocatalysts, and proline derived organocatalysts in both
aqueous and non-aqueous media has been discussed.
Momordica balsamina L.: An Appraisal on Morphology, Ecological Diversity,
Phytochemistry, Pharmacological and Biotechnological Applications
Authors: Sabiu Saheed , Aruwa Christiana Eleojo , Mohanlall Viresh , Baijnath Himansu
Published: September 2020

Background:

Momordica balsamina L. is a monoecious climbing vine and perennial herb native to the tropical
regions of Asia, Arabia and the Caribbean, and with prominent presence in Nigeria, Botswana, Namibia, Swaziland and
Southern African provinces. While evidence of its anecdotal usage as medicine exist, scientific reports complementing the
claims are still emerging or at their infancy.

Objective:

This review appraised the morphology, therapeutic and biotechnological significance of M. balsamina.

Method:

Online resources such as Google Scholar, PubMed, ScienceDirect and MeSH were utilized for literature search
and included relevant information from inception till May 2020 to streamline sought outcomes for in-depth discussion.

Results:

The data gathered and considered worthy of inclusion in this study revealed that M. balsamina is rich in phytonutrients of medicinal significance with cucurbitane-type triterpenoids, balsamin and momordins well characterized and fully elucidated. These compounds and other novel bioactive agents in M. balsamina have found remarkable pharmacological relevance and could further be harnessed for use against several debilitating human disorders.

Conclusion:

The potential applications of M. balsamina as nutraceutical and pharmaceutical agent should not be undermined. Also, with the inadequate toxicological data on this wild species, its consumption should be with caution and
translational studies that could advance scientific knowledge and aid better understanding of both its pharmacokinetics
and pharmacodynamics without sidelining its potent biotechnological applications are highly encouraged. It is hoped that
this paper will provide baseline information that could serve as a guide and inspiration for further studies on the prospects
of M. balsamina.
Inspecting Briquette Machine with Different Faults
Authors: Garg Divesh , Garg Reena , Garg Vanita
Published: September 2020

Background:

A briquette machine can be considered very useful in modern times as the
need for energy consumption is increasing rapidly. Considering the harm to the environment, the
study of the briquette machine is the need of present times. In this paper, the operative unit is considered
as briquette machine, also known as bio-coal, which is used for agroforestry waste.

Objective:

A single operative unit has been analyzed stochastically. The inspection of the breakdown
of a unit reveals the feasibility of the unit under the supervision of either ordinary or expert
repairmen. Two types of faults are revealed by the repairmen, either minor or major. Minor faults
are repaired immediately by the same repairmen, but whenever a major fault is held, the machine’s
fault will be handled by an expert person.

Method:

It is assumed that the repair needs no modification once served. Availability, Mean-time
for system failure, and profits are analyzed by utilizing the Regenerative point graphical technique
and Semi-markov process.

Result:

The study reveals that the mean-time for system failure of the system model goes on decreasing
as the failure rate increases and the availability goes on decreasing as failure-rate increases.
Moreover, the study shows that the systems' profit goes down on an increase in Failure-rate.

Conclusion:

Findings of the study support the hypothesis that the limits of failure/repair/inspection
rate will surely have effective profitability. Moreover, it is found that the utility of the scale of operation
can easily be derived. The practical importance of biomass briquettes for burning coal or
wood is very well appreciated.
Dealing with COVID-19: Lessons Learned from the Italian Experience
Authors: Aliberti Silvana Mirella , De Caro Francesco , Boccia Giovanni , Caruso Rosario , Capunzo Mario
Published: September 2020

Italy was the first western nation affected by the pandemic and was observed as a pilot case in
the management of the new coronavirus epidemic. The outbreak of COVID-19 disease has been challenging
in Italy. On June 25, 2020 there were 239,821 total cases, of which 33,592 were deaths nationwide.
Three lessons emerged from this experience that can serve as a blueprint to improve future plans for the
outbreak of viruses. First, early reports on the spread of COVID-19 can help inform public health officials
and medical practitioners in effort to combat its progression; second, inadequate risk assessment related to
the urgency of the situation and limited reporting to the virus has led the rapid spread of COVID-19; third,
an effective response to the virus had to be undertaken with coherent system of actions simultaneously.
Comparative analysis of shielding characteristics of signal-blocking cables for railway transport
Authors: Andreev V. A. , Bulkhin A. K. , Popov B. V. , Popov V. B.
Published: September 2020

The objective of this article is to compare the shielding characteristics of the most applicable signal-blocking cables designs. In this paper, based on calculations and experimental studies, a comparative analysis of the shielding characteristics of cables with a solid pressed screen and a screen consisting of an aluminum-polyethylene tape and a layer of aluminum wires is performed. Special attention is paid to the characteristics of the influence of external electric fields. Measurements of the ideal protective action coefficient of signal-blocking cable samples were made, and an estimated calculation of shielding attenuation was performed. For a comparative assessment of the influence of external transverse high-frequency fields, measurements of transient attenuation at the near end were made on samples of signalblocking cables under study. It is shown that the shielding characteristics of cables with a solid aluminum screen are better than those of cables with a screen made of aluminum-polyethylene tape and aluminum wire layer. Recommendations are given – on electrified railways, preference should be given to signal-blocking cables with a solid aluminum screen.
Overview of diagnostic methods for electric pump units of satellite platforms
Authors: Matveev S. A. , Zhukov Y. A. , Korotkov E. B. , Shirobokov O. V. , Nadezhin M. I. , Ladygin A. P.
Published: September 2020

The article gives a brief description of the electric pump unit of the satellite thermal control system as an electromechanical subsystem. General issues of development of diagnostics systems for electromechanical systems are considered. Defects of system parts and the reasons leading to failures of electromechanical units are determined. Using modern sources, an overview of methods and approaches to solving problems of diagnosing defects in the mechanical, electrical, and electromagnetic parts of the systems under study is presented. The advantages and disadvantages of modern approaches are noted. A diagnostic chart of prospective current diagnostics is shown. The paper gives an effectiveness assessment of various methods and practical recommendations for the use of the presented methods for the diagnostics system design for electric pump units of satellite systems. Promising areas of research in the field of diagnostics of electromechanical systems, such as the use of current methods or methods based on neural networks, have been identified.
A Reflective Account on Human Translation and Interpreting Faced with the Automated Text and Speech Processing Tools
Authors: Munyangeyo Théophile
Published: September 2020

This reflection aims to depict the prospective position and role of translation and interpreting in the globalised world. Demographic factors point to a long-lasting multilingualism, which reflects the co-existence of linguistic identities within a variety of settings. From schools, to workplaces and communities, different languages are and will continue to be in use. In many countries, there is an increasing wave of using vernacular and migrant languages in education. However, the current global academic discourse on language situations does not sufficiently reflect this new looming reality. The focus of translation and interpreting studies has traditionally been placed on those languages that were perceived as internationally important. One would assume that economic and diplomatic interests have influenced that approach and attitude. With changes affecting the globalised world in relation to the rise of some emerging economies and new resources, it is clear that the interlingual communication will be one of the greatest challenges of the coming age. In this regard, a new paradigm in overall language promotion and education must be formulated within which human translation and interpretation continue be seen as important skills to be generally acquired.
SHINUAZRI'S PHENOMENON IN THE EUROPEAN CULTURE
Authors:   Cong Wan Tong Pacific State University, Wan Tong Cong , Martynova N.V. ,   N.V. Martynova  Pacific State University
Published: September 2020

The phenomenon of chinoiserie, so-called «kitayschiny» (from the French. «Chinoiserie»), determines the specific art solutions, often far from authentic Chinese art, embodied representation of Europeans on the life of China and established in the framework of the phenomenon of style, define some morphological features of European art. The authors of this article, touching the history and development of chinoiserie, considering the principles of the transformation of European stylistic solutions, fell under the spell of the distant and unknowable East.
Itinerarios de movilidad y precarización: experiencias y narrativas infantiles sobre la crisis habitacional
Authors: Carrasco Pons Silvia
Published: September 2020

Este artículo analiza las experiencias infantiles de la crisis económica y de la situación de emergencia habitacional en España a través de las narrativas de niños y niñas. Estas se han obtenido a partir de una etnografía comparativa en dos escuelas ubicadas en barrios desfavorecidos de la región metropolitana de Barcelona, durante la cual se han realizado entrevistas con niños y niñas implementando técnicas participativas y visuales. Los relatos de estos menores destacan por la des-responsabilización de los miembros del grupo doméstico de su situación de precariedad. Los niños y niñas reproducen ideologías dominantes – y adultas – sobre la vivienda, aunque también crean sus propias representaciones sobre qué constituye un “hogar” y cómo les afecta su situación habitacional. Finalmente, las narrativas permiten identificar vínculos entre trayectorias de movilidad, interpretadas a partir de los conceptos de “movilidad inter-residencial” y “movilidad intra-residencial”.
Goffman y las situaciones sociales: algunas enseñanzas teórico-metodológicas
Authors: Ribes Alberto Javier
Published: September 2020

El objetivo de este artículo es extraer algunas enseñanzas que creemos fundamentales para la sociología, y para las ciencias sociales en general, del enfoque sociológico de Goffman. Presentaremos, pues, una sociología de la práctica sociológica de Goffman. Trataremos de mostrar que la obra de Goffman es fundamentalmente una teoría de la situación social moderna, y, al tiempo, una sociología de algunas situaciones sociales concretas. En la obra de Goffman encontramos un espacio central, las situaciones habituales de la vida cotidiana, y cuatro espacios que se relacionan con ese espacio principal y también entre ellos: las situaciones sociales laxas, las situaciones de monitorización extrema, las situaciones al-margen y las situaciones sociales totales.
La protección ocupacional de nuevos riesgos sociales: conciliación y formación proporcionada por la empresa
Authors: Doblytė Sigita , Gutiérrez Rodolfo , Pruneda Gabriel
Published: September 2020

Una parte creciente del desarrollo del Bienestar Ocupacional (BO) gira en torno a la protección de nuevos riesgos sociales, principalmente mediantes programas ofrecidos por las empresas para facilitar la conciliación entre vida personal y laboral, y la formación continua. Estos programas son de singular importancia para la protección activa de la empleabilidad en un contexto postindustrial. Este artículo tiene como objetivo ofrecer un mapa del desarrollo reciente del BO. Se inicia con una perspectiva comparada dentro del ámbito europeo, para luego describir los perfiles de los beneficiaros de esos programas y analizar cómo las características de las empresas y de los puestos de trabajo condicionan el acceso a los mismos. Los resultados confirman el carácter limitado del BO en el caso español, pero también indican trayectorias recientes de expansión de los principales beneficios, conciliación y formación; algo que tiene gran interés por ocurrir durante un ciclo de crisis
Mapeando a la élite en las universidades chilenas. Un análisis cuantitativo-multidimensional
Authors: Villalobos Cristóbal , Quaresma María Luisa , Franetovic Gonzalo
Published: September 2020

Uno de los más importantes mecanismos de producción y reproducción de las élites sigue siendo la educación. Este artículo busca mapear a las élites en el campo universitario chileno, identificando las principales carreras y universidades en donde este grupo se concentra y, además, tipificando cómo estas instituciones promueven (o no) los procesos de movilidad de las élites. A través de un análisis estadístico diversificado, se concluye que las élites académicas y sociales en Chile se concentran principalmente en dos selectos grupos: en unas pocas instituciones tradicionales, con alto prestigio y alto nivel de selectividad; y en algunas instituciones nuevas, de carácter privado y focalizadas en capturar a los grupos sociales más altos del país. Adicionalmente, los resultados muestran que el sistema de educación chileno promueve bajos niveles de movilidad de la élite, estructurándose en un sistema que permite perpetuar los procesos de su reproducción de este grupo.
Prácticas de distinción, justificación y reproducción de la elite: evidencia de los ámbitos financiero y tributario en Chile
Authors: Atria Curi Jorge , Hernández Aracena Javier
Published: September 2020

Este artículo aborda los fenómenos de construcción y persistencia de las elites desde una perspectiva de prácticas sociales, enfocándose específicamente en los procesos de distinción, justificación y reproducción. Con base en 53 entrevistas en profundidad a miembros de la elite económica en Santiago de Chile, se analizan distintas prácticas simbólicas, relacionales e institucionales asociadas a este grupo, favoreciendo la conservación de posiciones, privilegios y centralidad en el contexto de profundas transformaciones sociales y económicas en el país. Partiendo de estos hallazgos, el desarrollo económico chileno se muestra impulsado por prácticas apoyadas en procesos adscriptivos y no meritocráticos de asignación de posiciones y recursos.
Cuidados y crisis del coronavirus: el trabajo invisible que sostiene la vida
Authors: Moré Corral Paloma
Published: September 2020

Esta reflexión aborda la organización social de los cuidados a la luz de la crisis de la COVID-19. Los argumentos aquí expuestos se apoyan en la literatura existente y en mi propio trabajo de campo, con el doble objetivo de esbozar un análisis sobre esta crisis y de lanzar preguntas que abran líneas de investigación en este nuevo escenario.

Los trabajos de cuidados se exploran en dos sentidos: por un lado, las actividades que normalmente se prestan como servicios públicos o privados y que durante el estado de alarma son realizados en los hogares, siendo compatibilizados en muchos casos con el teletrabajo; por otro lado, las actividades que han seguido prestándose en tanto que son "esenciales".
Aislamiento de Escherichia coli productora de toxina Shiga (STEC) en heces de ganado y detección de factores de virulencia asociados con su patogénesis
Authors: Quiguanás-Guarín Edwin , Granobles-Velandia Claudia , Arango-Gil Brayan , Giraldo-Rubio Valentina , Castaño-Osorio Jhon
Published: September 2020

Objetivo: Aislar STEC en las heces del ganado bovino en el municipio de Ulloa, Valle del Cauca y detectar factores de virulencia asociados con la patogénesis. Materiales y métodos: Se tomaron 21 muestras provenientes de bovinos, las cuales fueron tomadas directamente del recto del animal mediante hisopos. Las muestras se procesaron hasta obtener colonias puras a las cuales se les evaluó la presencia de los genes stx1, stx2, eae, saa y hlyA mediante PCR y posteriormente, se evaluó el efecto citotóxico de las muestras positivas sobre células Vero (ATCC-CCL-81.4). Resultados: De las 21 muestras de heces de bovinos,12 presentaron bacterias con uno o ambos genes stx. Se obtuvieron 106 aislamientos totales de STEC y se observaron diferencias en cuanto a la presencia y ausencia de los genes de virulencia evaluados en los aislamientos de cada bovino, obteniendo cinco combinaciones de genes. 48 aislamientos presentaron únicamente el gen stx2 y 58 presentaron tanto el gen stx1 como el gen stx2; de los 106 aislamientos, se detectaron 44 con el gen hlyA y 57 con el gen saa. Conclusiones: Todos los sobrenadantes de STEC analizados mostraron actividad citotóxica sobre las células Vero, mientras que en ausencia de STEC las células formaron monocapa después de 48 h de incubación. Este trabajo es el primer reporte en Colombia que aporta información sobre la presencia de STEC en el ganado bovino, la presencia de factores de virulencia y el potencial efecto citotóxico que poseen estas cepas nativas.
Association of prodromal type 1 diabetes with school absenteeism of Danish schoolchildren: a population-based case control study of 1,338 newly diagnosed children
Authors: Thingholm Peter , Gaulke Amanda , Eriksen Tine M. , Svensson Jannet , Skipper Niels
Published: September 2020

Objectives To investigate
school absenteeism before the clinical diagnosis in children who developed type
1 diabetes.

Research Design and
Methods Population based retrospective case control study involving all Danish
public-school children that developed type 1 diabetes (n= 1 338) from 2010-2017 matched 1:5 on sex and date of birth to children without
diabetes (n= 6 690). Monthly absenteeism was compared 12 months before to 12 months after the diagnosis of type 1 diabetes.

Results Seven to 12 months before the diabetes diagnosis the mean
(SD) number of days
absent from school per month was 0.93 (1.78) among children with diabetes and
0.93 (1.82) among controls (difference:
-0.004 days, p=0.94). From 4 months before diagnosis, children who
developed diabetes had a statistically significant increase in absenteeism
compared with controls (difference: 0.24 days, p<0.05).

CONCLUSION Children
who were diagnosed with type 1 diabetes had increased school absenteeism 4
months prior to diagnosis.
Effects of DPP-4 Inhibitor Linagliptin versus Sulfonylurea Glimepiride as Add-On to Metformin on Renal Physiology in Overweight Patients with Type 2 Diabetes (RENALIS): A Randomized, Double-Blind Trial
Authors: Muskiet Marcel H.A. , Tonneijck Lennart , Smits Mark M. , Kramer Mark H.H. , Ouwens D. Margriet , Hartmann Bolette , Holst Jens J. , Touw Daan J. , Danser A.H. Jan , Joles Jaap A. , Raalte Daniël H. van
Published: September 2020

OBJECTIVE To
compare effects of the DPP-4 inhibitor linagliptin , with a sulfonylurea on renal
physiology in metformin-treated T2DM-patients.

RESEARCH-DESIGN AND
METHODS In this double-blind randomized trial, 46 overweight
T2DM-patients without renal impairment received once-daily linagliptin (5mg) or
glimepiride (1mg) for 8 weeks. Fasting GFR and effective renal plasma flow
(ERPF) were determined by inulin and para-aminohippuric-acid clearances. Fractional
excretions (FE), urinary damage-markers, and circulating DPP-4-substrates (a.o.
GLP-1, and SDF-1α) were measured.

RESULTS HbA1c-reductions were similar with linagliptin (–0.45±0.09%)
and glimepiride (–0.65±0.10%) after 8 weeks (P=0.101). Linagliptin
versus glimepiride did not affect GFR, ERPF, estimated intrarenal hemodynamics
or damage-makers. Only linagliptin increased FENa and FEK,
without affecting FELithium. Linagliptin-induced change in FENa correlated with SDF-1α
(R=0.660), but not with other DPP-4-substrates.

CONCLUSIONS Linagliptin
does not affect fasting renal hemodynamics compared to glimepiride in T2DM
patient. DPP-4-inhibition promotes modest natriuresis, possibly mediated by SDF-1α,
likely distal to the macula-densa.
Analisis Penyaluran dan Penggunaan Dana Desa (Studi pada Nagari Tujuah Koto Talago, Kecamatan Guguak, Kabupaten 50 Kota)
Authors: Marthalina Intan , Sebrina Nurzi
Published: September 2020

This research aims to determine the Distribution and Use of Village Funds In villages in Tujuah Koto Talago, Guguak District, Limapuluh Kota District West Sumatrera, there are three (3) aspects in the use and distribution of village funds namely Financial Aspects in Use of Village Funds, Aspects of Procurement of Goods and Services in the Use of Village Funds and Aspects of Reliability of Internal Control Systems. To achieve that goal, qualitative research method with interpretative approach is used. Data Sources are Primary data and Secondary data. Data collection techniques are carried out by observation, interviews, and document. The results showed:(1) Finance in the use of village funds in disbursement has been delayed, namely liquid one-stage funds in May and second stage funds in September and prioritized use of infrastructure (2) procurement of goods and services in the use of village funds are carried out efficiently, effectively, transparently, community empowerment, mutual cooperation and accountability (3). Reliability of SPI is carried out based on the internal environment, risk assessment, control activities, information and communication and monitoring carried out by the sub-district head, nagari guardian, nagari, bamus and the communityKeywords: Distribution and Use of Village Funds
Pengaruh Karakteristik Pemerintah Daerah Terhadap Kondisi Financial Distress Pemerintah Daerah Kabupaten dan Kota Se-Indonesia Periode 2015-2017
Authors: Sari Mutiara , Arza Fefri Indra
Published: September 2020

This study aims to obtain empirical evidence about the influence of the characteristics of local governments on local government financial distress in districts and cities throughout Indonesia for the period 2015-2017 whose data was obtained from the BPK and BPS. The dependent variable in this study is financial distress and its independent variables, namely the characteristics of local governments which consist of financial independence, the degree of decentralization, the complexity of local governments that are proxied by population, expansion of regions proxied by the administrative age of regional governments and area. The value of financial independence, population and regional expansion has a positive and significant effect on financial distress, while the value of the decentralization degree and area has a negative and significant effect on the financial distress of the regency and city governmen in Indonesia.Keywords: Local Government Finance, Characteristics of Local Government; Financial Distress
AnalisisKinerja Keuangan Perusahaan Sektor Pertambangan yang Terdaftar di Jakarta Islamic Index dengan Menggunakan Economic Value Added
Authors: Fitra Halkadri , Agustin Henri , Taqwa Salma , Mulyani Erly
Published: September 2020

This study aims to determine the financial performance of mining sector companies listed on the Jakarta Islamic Index based on EVA (Economic Value Added) analysis. The research conducted is a descriptive study with a quantitative approach using secondary data from 2014 to 2018 obtained from the Indonesia Stock Exchange and companies that are the object of research. The study population is all mining sector companies listed on the Jakarta Islamic Index while the sample uses a purposive sampling method with the sample taken is the mining sector companies listed on the Jakarta Islamic Index in the June-November 2019 period. Data analysis starts from the calculation of net operating profit after taxes, weighted average capital costs, invested capital, costs of capital and finally calculating EVA values from 2014 to 2018. The results show that the financial performance of mining companies listed on the Jakarta Islamic Index is well indicated by positive EVA values so it can be concluded that the management of the company has been able to provide added value to shareholders and investors.Keywords:Cost of Capital, EVA, Weighted Average Cost Of Capital
PKM Peningkatan Kemampuan Aparatur Nagari Dalam Mengelola Keuangan Nagari di Kabupaten Padang Pariaman Melalui Pelatihan Pengelolaan Keuangan Desa
Authors: Arza Fefri Indra , Handayani Dian Fitria , Honesty Fiola Finomia
Published: September 2020

The implementation of village fund management even though there are rules as references in its financial management does not mean that it does not encounter various obstacles. The main obstacle faced by village officials is the competency problem of inadequate apparatus, and the lack of training and mentoring obtained to improve their competence. Some efforts are needed for empowerment which in the discourse of community development are linked to the concepts of self-reliance, participation, networking and social justice.This empowerment effort is carried out in the form of training activities provided to the village apparatus (nagari) village financial management processes, especially in preparing the budget. This training activity will be carried out through several stages. The activities carried out are: initial observation to find out the problems and needs of partners, and training of village apparatus related to village budgeting. After the material was given, participants were then given training on village budget formulation and village RKP preparation training. Based on the results of the exercise, it is known that most of the trainees were able to understand the procedures for drafting Village Budget and have been able to compile Village Budget well. Besides that in the preparation of the Village RKP, most of the training participants were also able to complete the training well.Keywords: Village Financial Management, Village Budget, Village RKP
Analisis Praktek Income Smoothing dan Faktor Penentunya Pada Perusahaan Indek LQ45 di Indonesia
Authors: Tasman Abel , Mulia Yudi Suci
Published: September 2020

Income smoothing is a management strategy to reduce the level of earnings fluctuations to achieve the desired level of profit by shifting revenue and expenses among different reporting periods. Income smoothing could adversely affect the decision-making process of investment. Income smoothing was tested by using The Eckel Index (1981) to define the companies into smoothers category and non-smoothers category. Eckel index compares coefficient variation for change in net income with changes in net sales over a period. This study aims to determine the effect of independent variables that are firm value, company size, profitability, dividend payout ratio and financial leverage to the dependent variable that is income smoothing. This reserach uses logistic regression analysis. The population in this study is companies listed on the LQ45 Index in 2013-2017. The method used for sampling is purposive sampling with the sample size is 105. The result of this study shows that, simultaneously, independent variables significantly affect the dependent variable. Partially, company size and profitability have a negative significant effect on income smoothing, the dividend payout ratio has a positive significanteffect on income smoothing, while firm value and financial leverage have a negative no significant affect on income smoothingKeywords: firm value, company size, profitability, dividend payout ratio, financial leverage, income smoothing
Pengaruh Mekanisme Corporate Governance Terhadap Konservatisme Akuntansi Dengan Intensitas Fair Value Sebagai Pemoderasi
Authors: Alvino Kazbarani , Sebrina Nurzi
Published: September 2020

The purpose of this research is to examine the effect of corporate governance mechanisms that are moderated by fair value on the level of accounting conservatism. The corporate governance mechanism consists of an independent commissioner, an institutional ownership structure, a foreign ownership structure and audit quality.  Research conducted on manufacturing companies and financial companies listed on the Stock Exchange period 2016-2018, purposive sampling method was used to determine the research sample so that 93 manufacturing companies and 52 financial companies was obtained. Hypothesis testing is done by multiple regression methods. The results showed that the independence of commissioners had a positive effect on the level of accounting conservatism. In manufacturing companies, institutional ownership structure does not affect the level of conservatism, whereas in financial companies, institutional ownership structure influences the level of accounting conservatism. Other corporate governance mechanisms, foreign ownership and audit quality, do not influence the level of accounting conservatism in both manufacturing and financial companies. The intensity of fair value in both sectors of the company has a negative effect, or weakens the relationship of corporate governance mechanisms to the level of accounting conservatism Keywords: Accounting Conservatism; Fair Value; Corporate Governance
Peranan Penyusunan Laporan Keuangan Dalam Penyajian Informasi Keuangan Pada BMT At-Taqwa Muhammadiyah Sumatera Barat
Authors: Suwita Leli Wita
Published: September 2020

This study aims to analyze how the role of financial statement preparation is to find out information relating to the financial position and performance of a corporate entity which includes the realization of the budget report, balance sheet, cash flow statement, and reports on the financial statement notes. The research method used is a qualitative method that compares financial statements between 2016 and 2018. The financial statements presented by BMT At-Taqwa Muhammadiyah West Sumatra in the form of a balance sheet and income statement, where an increase in value from the reporting date of the current year with the previous year, of the report there are still shortcomings in the reporting. BMT At-Taqwa Muhammadiyah West Sumatra is recommended to make all financial reports needed by financial information from BMT At-Taqwa Muhhammadiyah West Sumatra.Keywords: Role; Financial Statements; Financial Information.
Reinventar a primavera, ou as filiações da revolta
Authors: Didi-Huberman Georges
Published: September 2020

O artigo discute a questão do recomeçar em Ernst Bloch e Aby Warburg, relacionando-o ao retorno e à repetição, bem como ao papel da imaginação na acepção blochiana de utopia. Nesse sentido, repensa-se o lugar do Renascimento na história da arte, enquanto se discute uma genealogia da revolta que envolve a insurreição camponesa de Thomas Müntzer e a insurreição científica de Giordano Bruno, mas também a posição de Martinho Lutero face à sublevação, na chave de uma iconografia política. Neste movimento, destacam-se aproximações relevantes e frutíferas entre os pensamentos de Bloch e Warburg sobre as especificidades do retorno de ambos ao Renascimento e, deste, à Antiguidade.
The Factors Affecting the Business Expectation of Human Resources in Entertain and Event Management
Authors: Thuong Do Huy , Hong Nguyen Thi Phuong
Published: September 2020

This research analysizes the factors affecting the business expectations of human resources in entertainment and event management. The research results have showed that of the 5 factors affecting the human resource expectations of businesses in entertainment and event management, the factor “professional knowledge” has the biggest impact on the expectations of the businesses. Next to it are “attitude”, “skill” and “ability”. The factor “fundamental knowledge” has the least influence on the expectations of the businesses.
O primeiro cinema nas páginas das revistas curitibanas (1907-1913)
Authors: Kaminski Rosane
Published: September 2020

Este artigo discute os vestígios do primeiro cinema em Curitiba, Brasil, nas páginas das principais revistas ilustradas que circularam na cidade entre 1907-1913. Naqueles anos, entre outros aspectos da modernização urbana, os serviços gráficos se expandiam em Curitiba, o que permitiu ampla circulação de revistas ilustradas com charges, publicidades e fotografias. Tais periódicos faziam constantes remissões aos lugares de consumo do cinema, que chegara na cidade por intermédio de empreendedores europeus. Em 1909, por exemplo, a revista de humor intitulada“Cinema”evidenciou algumas das conexões existentes entre as próprias revistas ilustradas e aquele primeiro cinema, todos partícipes de um novo tipo de consumo cultural. O objetivo do texto é avaliar aquelas revistas enquanto catalisadoras de um fenômeno cultural amplo, do qual elas mesmas participavam, e cujas dimensões eram transnacionais.
O Malho, a imprensa empresarial e a criação da revista O Tico-Tico.
Authors: Gonçalves Roberta Ferreira
Published: September 2020

A modernização das oficinas da revista O Malho, em 1905, levou ao processo de segmentação de impressos e a consequente organização empresarial que deu origem à Empreza O Malho e, posteriormente, a Sociedade Anônima O Malho. A criação da revista ilustrada infantil O Tico-Tico neste mesmo ano representou um passo fundamental na concretização do projeto editorial da empresa, que visava atingir a toda a família com suas revistas. A revista O Tico-Tico, ao mesmo tempo projeto intelectual e jornalístico, acabou se tornando a principal referência para a manutenção da empresa até os anos 1960. Neste artigo, nosso objetivo é refletir sobre a criação da revista O Tico-Tico como um evento importante para a organização empresarial de O Malho, por sua vez uma referência importante para a reorganização estrutural da imprensa periódica no século XX.
A neologia no português do Brasil: resultados de pesquisas sistemáticas e tendências para o futuro da área
Authors: Serra Luís Henrique , Ribeiro Pâmela Teixeira , Mota Ariane Vicente
Published: September 2020

Este texto é uma revisão crítica da conferência apresentada pela professora Ieda Maria Alves no evento Abralin ao Vivo – Linguists Online. A conferência ocorreu em 19 de julho de 2020 e foi intitulada O que os estudos sobre a neologia do português do Brasil (PB) nos ensinam?. Na exposição, a pesquisadora propôs uma reflexão sobre o que pode ser estabelecido por meio da observação sistemática dos neologismos do PB e, para isso, dividiu sua apresentação em três partes, a saber: conceito de neologia e neologismo, neologia e aspectos culturais, e neologia e lexicografia. Ao longo da apresentação, a professora demonstrou que a pesquisa em neologia contribui para os estudos do léxico do português, bem como para os estudos de morfologia, sintaxe, semântica, entre muitos outros aspectos observáveis que podem ser analisados em uma língua, além de possibilitar a compreensão dos aspectos sociais, históricos e culturais do Brasil.
A Study of Adjustment of College Student In Relation To Certain Variables in Bharuch Distract
Authors: Kapadiya N. B.
Published: September 2020

The present study was conducted on adjustment in surat city. A random sample was selected from four urban and rural colleges and studying in B. Sc and M. Sc Adjustment is one of the most important psychological activities of human being. The present study was conducted on 5 urban college and 5 rural college students. K. G. Desai adjustment inventory was administered and to find out the result T – test was applied. The findings reveal that there are no significant difference between adjustment scores of boys and girls, B.A and M.A students. The third group find of the study reveals that is a significant difference between adjustment scores of urban and rural College.
Clinicians dilemma in the management of acute flare-up wheeze with asthma: An update
Authors: Paramesh Haralappa
Published: September 2020

Asthma is the earliest onset of non-communicable respiratory disease with a significant psycho-socio economic burden. Each country have their own guidelines to manage asthma for their need based on availability, accessibility, and affordability. The acute flare-up of asthma, where there is a progressive increase of symptoms of asthma, causing higher morbidity and mortality. The clinician often confronts with a dilemma in the management – in confirming the diagnosis of asthma, look for the risks for flare-up and mortality, followed by assessing the severity of flare-up for proper management. There is some dilemma in using the nebulized steroid in acute flare-up of asthma. The author highlights the current knowledge in clearing those issues for the practicing clinicians.
Comorbidity of acne and disorders of intestinal microbiocenosis: theoretical and real
Authors:   Omsk State Medical University, Omsk, Russia, Trukhan Dmitry I.
Published: September 2020

Совершенствование диагностических возможностей обусловливает значимый рост клинических ситуаций, когда уже сложно говорить о наличии у пациента одного заболевания – в настоящее время в большинстве клинических случаев присутствует сочетанная или сопутствующая патология. В рамках обзора рассмотрены вопросы коморбидности акне и нарушений кишечного микробиоценоза в теоретическом и практическом аспектах. В 1930 г. был сформулирован гастроэнтерологический механизм связи между эмоциональными и нервными состояниями (беспокойством, депрес-сией) и кожными заболеваниями (такими как прыщи/акне) и обозначен как gut–brain–skin axis (ось «кишечник–мозг–кожа»). В течение нескольких десятилетий эта гипотеза была бездействующей. Однако в обзорах последнего десятилетия приведены многочисленные факты, косвенно свиде-тельствующие о праве гипотезы «кишечник–мозг–кожа» на существование и являющиеся базисом предположительной коморбидности акне и на-рушений кишечного микробиоценоза. В реальной клинической практике эта связь не представляется столь очевидной и требует дальнейшего из-учения механизмов и эффектов оральных пробиотиков при акне. Ключевые слова: акне, нарушения кишечного микробиоценоза, коморбидность, гипотеза «кишечник–мозг–кожа», пробиотик, пребиотик, гастроэн-теролог, дерматолог. Для цитирования: Трухан Д.И. Коморбидность акне и нарушений кишечного микробиоценоза: теоретическая и реальная. Consilium Medicum. 2020 (22); 7: 73–77. DOI: 10.26442/20751753.2020.7.200280
The theme of syphilis in fiction XVI–XX centuries
Authors:   Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia, Golousenko Igor Yu. , Medvedev Kirill I. ,   Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Published: September 2020

До начала ХХ в. сифилис был довольно распространенным заболеванием, что нашло яркое, запоминающееся отражение в художественной лите-ратуре тех времен. Этот факт сыграл большую роль в распространении знаний о последствиях этого заболевания среди читающей публики, так как специальная медицинская литература доступна лишь небольшой прослойке населения, преимущественно вооруженной специальным образо-ванием. Ключевые слова: сифилис, последствия инфекции, художественная литература. Для цитирования: Голоусенко И.Ю., Медведев К.И. Тема сифилиса в художественной литературе XVI–XX вв. Consilium Medicum. 2020; 22 (7): 84–86. DOI: 10.26442/20751753.2020.7.200326
A study on fungal speciation and drug susceptibility testing
Authors: Shaik Mujafar  , Boddu Ganesh  , Kesani Meghana  , Nuthalapati Amani  , Shaik Faizan Ali
Published: September 2020

Fungal infections affect many people but most of these do not come to light as they are mild in clinical presentation. Candidiasis is the frequent fungal infection involving mucosa, skin, nails and internal organs caused by different species of Candida and Candida albicans being the prototype. The clinical manifestations vary with duration and severity. It occurs mostly as a comorbid disease with a primary disease or disorder. Candida comes under the phylum Fungi Imperfecti, order Moniliales and family Cryptococcaceae. Genus Candida comprises of 20 important species recognised as pathogenic in humans, of which 7 are renowned opportunistic pathogens. The following are some of the known species: Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Candida guilliermondii, Candida parapsilosis, Candida lusitaniae, Candida kefyr, Candida rugosa, Candida dubliniensis and Candida viswanathii. Among all the fungi, 600 species are identified to be causing infections in human. Candida albicans being one of the normal human commensals may cause infections from mild to severe forms, which is influenced by molecules that helps in adhesion and invasion, hydrolases, yeast to hyphal transition, biofilms etc. In general, equal importance has not been give to fungal infections as is being given for bacterial infections. Nowadays newly emerging species are on the tract as to cause infections and their identification profile being indeterminate, which could be confirmed only by molecular methods. Overall C.tropicalis was the frequent species causing infections clinically and resistance was demonstrated against azoles and caspofungin by C.albicans and C.krusei. This may be due to extensive use of echinocandins as empirical therapy without susceptibility testing which can increase the development of resistance and may deduct treatment options. Hence, routine antifungal susceptibility testing has to be done. Out of all these things accurate epidemiological analysis and data can be provided regarding the burden of fungal infections around the globe. As tip of the iceberg, most of the fungal infections are not being reported as it is unnoticed without prominent clinical presentation and due to lack of complete documentation.
HEGEMONI PENGUASA TERHADAP WANITA DALAM PERTUNJUKAN KIDUNG SRI BEDHAYA
Authors: Hartikaningsih NFN , Andayani NFN , Wibowo Prasetyo Adi Wisnu
Published: September 2020

Monologue drama performances in Javanese seem rarely found. The monologue drama Song of Sri Bedhaya created by Trisno Santoso applies feminism as his approach. The purpose of this research is to describe and explain the form of ruler's hegemony towards women in the performance of the Song of Sri Bedaya by Trisno Santoso. The research method used in this research is descriptive qualitative with literature study and is not tied to the place of research. The results of the discussion in this study found 4 forms of authority hegemony towards women in the Song of Sri Bedhaya by Trisno Santoso, among others tend to say rude to subordinates, give threats to abdi, orders to meet personal affairs and play with women.Pertunjukan drama monolog dengan bahasa Jawa sepertinya jarang ditemukan. Drama monolog Kidung Sri Bedhaya yang diciptakan oleh Trisno Santoso menerapkan feminisme sebagai pendekatannya. Tujuan penelitian ini adalah mendeskripsikan dan menjelaskan bentuk hegemoni penguasa terhadap wanita dalam pertunjukan Kidung Sri Bedaya karya Trisno Santoso. Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan studi pustaka dan tidak terikat dengan tempat penelitian. Hasil pembahasan dalam penelitian ini ditemukan 4 bentuk hegemoni penguasa terhadap wanita dalam pertunjukan Kidung Sri Bedhaya karya Trisno Santoso, antara lain cenderung berkata kasar terhadap bawahan, memberikan ancaman kepada abdi, perintah untuk memenuhi urusan pribadi dan mempermainkan wanita.