bluuebunny/crossref_metadata_2025 huggingface dataset:
Usucapião extrajudicial: Inovação que conferiu celeridade ao procedimento declaratório de aquisição originária da propriedade imobiliária e revela-se meio adequado de solução de conflitos
Authors: Lourenço Heuler Costa , Denardi Eveline Gonçalves
Published: January 2025

Neste artigo, trataremos da análise da usucapião imobiliária, forma de aquisição, espécies, e a tramitação de seu procedimento declaratório pela via extrajudicial, ou seja, perante o Cartório de Registro de Imóveis da circunscrição do imóvel usucapiendo. Deste modo, seria o procedimento extrajudicial o mais seguro e célere para a declaração de tal direito? Os métodos empregados neste artigo são o dedutivo, sistêmico e axiológico, com emprego de pesquisa bibliográfica (doutrina, artigos científicos e legislação). Com efeito, o Poder Judiciário brasileiro está abarrotado de processos causados por motivos diversos, dentre eles, a ineficiência e a burocracia dos demais Poderes, materializadas pela desigualdade social, pela má gestão dos recursos públicos e pela corrupção. O problema é crônico e extremamente preocupante. Diante disso, crescem no país métodos adequados de solução de conflitos de interesses. Atualmente, a extrajudicialização é um dos mais eficientes e bem aceitos pelos operadores do direito, pois seus fatores preponderantes são a celeridade e a segurança jurídica. Dentre alguns exemplos, mencionam-se o divórcio direto, o inventário e a partilha, a conversão de união estável em casamento e a usucapião extrajudicial, recentemente instituída no Código de Processo Civil de 2015. Esta modalidade de aquisição originária da propriedade revela-se importantíssima, na medida em que serve para regularizar posses de imóveis, urbanos e rurais, num curto prazo de tempo, fortalecendo o setor imobiliário e a economia. A tramitação da usucapião extrajudicial ocorrerá em Cartório de Registro de Imóveis, desde que não haja oposição, e substitui o velho e moroso processo judicial de usucapião, o qual, per si, não possui prioridade de tramitação.
Analisis Efektivitas Implementasi Manajemen Talenta Aparatur Sipil Negara Dalam Upaya Pengembangan Karir Pegawai pada Instansi Kementerian Lingkungan Hidup dan Kehutanan
Authors: Basuki Afryantho Dwi , Rajab Ridwan , Sondang Silitonga Mala
Published: January 2025

Manajemen talenta berfokus sangat luas dengan mempersiapkan dan mengembangkan pegawai yang tepat pada pekerjaan. Kebijakan Manajemen Talenta ASN telah diamanatkan pada Peraturan Presiden Nomor 18 Tahun 2020 tentang Rencana Pembangunan Jangka Menengah Nasional 2020 – 2024 yang selanjutnya disebut (Perpres No 18 tahun 2020) yang secara garis besar memfokuskan pada Peningkatan Sumber Daya Manusia yang berkualitas dan berdaya saing dan Penguatan stabilitas Politik Hukum, Pertahanan dan keamanan serta Transformasi Pelayanan Publik. penelitian ini memiliki tujuan untuk mengetahui Bagaimana Evaluasi Implementasi Kebijakan Manajemen Talenta Dalam Upaya Pengembangan Karir Pegawai Negeri Sipil Pada Instansi Kementerian Lingkungan Hidup dan Kehutanan. Metode penelitian yang   digunakan   dalam   penelitian   ini   adalah   metode   deskriptif   dengan   pendekatan   kualitatif. Dimaksudkan agar penelitian ini mampu mengungkap fakta di lapangan secara lebih dalam dan lebih intensif atas pelaksanaan kebijakan manajemen talenta sehingga dapat memberi gambaran bagaimana strategi implementasi kebijakan manajemen talenta dalam upaya pengembagan karir PNS di Kementerian Lingkungan Hidup dan Kehutanan dapat berjalan dengan teknik pengumpulan data melalui wawancara, observasi dan telaah dokumen. penelitian ini juga menemukan hambatan-hambatan yang terjadi dalam pelaksanaan implementasi Kebijakan Manajemen Talenta Dalam Upaya Pengembangan Karir Pegawai Negeri Sipil Pada Instansi Kementerian Lingkungan Hidup dan Kehutanan, mulai dari standar kebijakan yang belum jelas, anggaran yang terbatas, komunikasi antar organisasi yang belum sempurna, kurangnya dukungan menyeluruh terhadap implmentasi dan juga pimpinan yang tidak mampu mengidentifikasi dan mengembangkan bakat internal.
Kata Kunci: Aparatur Sipil Negara, Implementasi Kebijakan, Kementrian Lingkungan Hidup dan Kehutanan, Manajemen Talenta.
PRODUCTION OF COMPOUND FEEDS IN THE CONDITIONS OF FARMS WITH LOADED RESERVATION OF DOSING AND MIXING
Authors:   Livestock farming institute of NAAS of Ukraine, Kharkiv, Ukraine, PISKUN Viktor , YATSENKO Yuriy ,   Poltava State Agrarian University, Poltava, Ukraine, ANTONENKO Sergii ,   Livestock farming institute of NAAS of Ukraine, Kharkiv, Ukraine, ZOLOTAROV Andrii ,   Livestock farming institute of NAAS of Ukraine, Kharkiv, Ukraine
Published: January 2025

Two options for resource-saving technology of mechanized production of compound feeds and PVMS with flexible connections were developed and implemented in farm conditions with loaded backup of Tweighing batchers and mixers and with loaded backup of mixers.
The studies have established that the dosing accuracy of 0.1 kg., the mixer shaft revolutions have an impact on the mixing quality indicator, so at 30 rpm. mixing quality is 95.18%, and at 46 rpm. – 96.1% and 1 min of mixing. Based on a multifactor experiment, polynomial linear and quadratic models were obtained for the mixing quality of compound feed ingredients due to the factors: rotation speed, number of blades and operating time with a mixer volume of 0.54 m3. The time spent on performing operations for the production of compound feed was determined and two versions of the cycle diagrams of the process of compound feed production of technological lines were constructed: with loaded redundancy of weighing batchers and mixers and with loaded redundancy of mixers.
The time of the initial cycle of the process of compound feed production of technological lines was established:
– with the redundancy of weighing batchers and mixers, the time of the initial cycle was 9.7 min. and the established cycle was 6.9 min.
– with the redundancy of mixers, the time of the initial cycle of the process of compound feed production of technological lines with a capacity of 2 tons per hour was 9.7 min. and the established cycle was 5.9 min.
It was established that the productivity of technological lines for the production of compound feed was:
– using technology with flexible connections and loaded redundancy of two weighing batchers and two mixers – 1.974 t.
– using technology with flexible connections and a weighing dispenser, which provides unloading of raw material components in two opposite directions and loaded redundancy of two mixers – 2.307 t.
Introduction
Authors: Gossard Julia
Published: January 2025

Introduction to the Special Section: Teaching History in the Time of Generative AI.
An Interview with Jeffery Washburn and Jennifer McCutchen
Authors: Gossard Julia
Published: January 2025

In January 2024, Critical Humanities published “AI Meets AI: ChatGPT as a Pedagogical Tool to Teach American Indian History” from Jeffrey Washburn and Jennifer McCutchen. The following interview expands on the ideas covered in their article and provides additional thoughts for our readers on the growth and future of AI, especially as it relates to the history of marginalized peoples.
Analisis Pelaksanaan ART Dan PrEP Dalam Membendung HIV: Perspektif Syariah
Authors: Rosidi Mohd Harifadilah , Ismail Abdul Manan , Mokhtar Ahmad Wifaq
Published: January 2025

Kadar peningkatan jangkitan baru HIV yang didominasikan oleh golongan muda disebabkan seks bebas terutamanya hubungan seks lelaki dengan lelaki sangat membimbangkan. Pada masa yang sama, pencegahan dan rawatan HIV dalam kalangan golongan LGBT di Malaysia merupakan isu kompleks yang melibatkan aspek perubatan dan sosial.Oleh itu, kajian ini bertujuan untuk menilai perkembangan pencegahan dan rawatan HIV di Malaysia dalam mengekang penularannya terhadap masyarakat sekaligus menganalisis perspektif Syariah terhadap usaha tersebut. Hasil daripada kajian ini menunjukkan pemberian ART dan PrEP oleh KKM dalam memerangi HIV di Malaysia adalah bertepatan dengan Syariah sesuai dengan tuntutan mencegah dan merawat penyakit serta menghilangkan kemudaratan. Walaubagaimanapun, mengamalkan Islam dalam kehidupan dengan menjauhi larangan agama mampu mengelakkan diri daripada jangkitan HIV. Kajian ini mencadangkan pihak KKM memperkasakan lagi usaha pencegahan dan rawatan HIV sementara ahli akademik serta pihak berautoriti agama juga perlu mengambil tanggungjawab untuk menyumbang kepada usaha memperbaiki Kesihatan awam dengan pengintegrasian nilai-nilai Islam dalam program kesihatan di Malaysia
Game Interaktif Wordwall Sebagai Inovasi Media Pembelajaran Digital Pada Anak Usia Dini
Authors: Nursarofah Nisna , Gandana Gilar , Rahman Taopik
Published: January 2025

Perkembangan teknologi yang terus berkembang berpengaruh pada bidang pendidikan. Anak usia dini sudah mengenal yang namanya teknologi, bahkan anak-anak lebih pintar dalam mengoperasikan teknologi khusunya handphone. Hal tersebut perlu menjadi perhatian khusus pendidik dalam menciptakan lingkungan yang nyaman bagi anak dan menyediakan media pembelajaran yang menarik bagi anak. Untuk mencapai hal tesebut, guru dapat menggunakan game interaktif wordwall sebagai media pembelajaran yang merupakan aplikasi website untuk membuat permainan interaktif dengan berbagai template yang tersedia. Dengan menggunakan template-termplate tersebut, pendidik dapat membuat konten materi yang sesuai dengan kebutuhan anak. Metode penelitian yang digunakan ini yaitu studi literatur yang bertujuan untuk menggali informasi mengenai game interaktif wordwall sebagai inovasi media pembelajaran digital pada anak usia dini. Hasil penelitian menunjukkan bahwa game interaktif wordwall efektif digunakan dalam pembelajaran khusunya pada anak usia dini. Karena ketika digunakan dalam proses pembelajaran dapat meningkatkan motivasi dan hasil belajar yang signifikan.
Analisis Pembelajaran Berbasis Puzzle Terhadap Keterampilan Motorik Halus Anak Usia Dini di TK Negeri Sangia
Authors: Maesyarah Maesyarah , Kaharuddin Kaharuddin , Wahyuningsih Sri
Published: January 2025

Penelitian ini bertujuan untuk mengetahui kemampuan motorik halus pada Anak Usia Dini di TK Negeri Sangia. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kualitatif. Jenis penelitian ini termaksud penelitian lapangan (field research) yakni penelitian berlangsung dilapangan dalam hal ini dilakukan di TK Negeri Sangia Kec. Sape. Sumber Data dan Teknik Pengumpulan Data. Sumber data dapat ditinjau dari dua macam yaitu data primer dan data sekunder. Data Primer yaitu data yang diperoleh secara langsung dari tempat penelitian, yaitu di sekolah TK Negeri Sangia Kec. Sape melakukan wawancara dengan, guru-guru, dan Data sekunder yaitu data yang diperoleh dari bahan dokumentasi berupa laporan-laporan kegiatan yang ada hubungannya dengan masalah yang diteliti. Teknik pengumpulan data dalam penelitian ini peneliti menggunakan teknik yaitu sebagai berikut: Observasi, Wawancara (interview), dan Dokumentasi. Instrument Penelitian yang digunakan dalam penelitian ini menggunakan Pedoman observasi, Pedoman wawancara, dan Pedoman dokumentasi. Pengujian Kredibilitas Data untuk memperoleh keabsahan data yang sudah diperoleh, maka penelitian menggunakan pengujian kredibilitas data  menggukanan Member Check (Cek Berulang-Ulang), Cross Check dan Triangulasi data. Hasil dari penelitian ini dapat mengidentifikasi perbaikan spesifik dalam keterampilan motorik halus pada anak dan memberikan rekomendasi untuk mengintegrasikan metode pembelajaran berbasis puzzle ke dalam pendidikan Anak Usia Dini. Penggunaan Puzzle akan berdampak positif pada perkembangan motorik halus anak. Permainan Puzzle juga memiliki pengaruh signifikan dalam mengembangkan keterampilan motorik halus anak usia 4-5 tahun di TK Negeri Sangia. Temuan ini akan memberikan dasar untuk merekomendasikan penggunaan permainan Puzzle sebagai bagian dari metode pembelajaran di pendidikan Anak Usia Dini.
Efektifitas Bermain Tanah Liat Plered dalam Mengembangkan Keterampilan Motorik Halus Anak Usia Dini
Authors: Amri Fadhila Alfiyatul , Muqodas Idat , Justicia Risty
Published: January 2025

Tujuan dari penelitian ini untuk menguji efektifitas bermain tanah liat dalam meningkatkan keterampilan motorik halus anak usia dini. Masih banyak anak yang saat ini keterampilan motorik  belum terstimulasi dengan baik  dikarenakan minimnya metode pembelajaran yang diberikan guru. Keterampilan motorik halus menjadi suatu stimulasi yang penting untuk anak agar tidak terhambat perkembangan anak yang lainnya. Tanah liat menjadi salahsatu media pembelajaran berbasis natural untuk berkembangan motorik halus anak bisa optimal. Penelitian ini menggunakan pendekatan kuantitatif dengan metode penelitian Pre-eksperimen dengan one-group pretest-posttest test design. Populasi pada penelitian ini berasal dari TK di kota Bekasi dengan jumlah sampel pada penelitian ini sejumlah 32 anak antar usia 5-6 tahun. Instrumen yang digunakan berupa lembar observasi. Teknik analisis data yang di gunakan berupa analisis statistik parametrik. Hasil penelitian yang didapat ditemukan perbedaan antara rata-rata pretest dan postest. Data di dapatkan hasil rata-rata pretes 55,78 dan postes 92,81. Hasil penelitain menunjukkan bahwa bermain tanah liat Plered efektif untuk mengembangkan perkambangan motorik halus anak. Dengan adanya penelitian ini, diharapkan dapat menjadi acuan untuk program pembelajaran kedepan nya untuk meningkatkan perkembangan motorik halus yang anak miliki.
Seni Musik Sebagai Pendekatan Pembelajaran Berbasis Budaya di Sekolah Dasar
Authors: Loustiawaty Lousy , Fitriyani Yani , Andri Nur Patrio
Published: January 2025

Kesenian musik merupakan salah satu kekayaan budaya dalam masyarakat, seni berperan  dalam  pemenuhan  kebutuhan  dasar  pendidikan  manusia  seperti  untuk memenuhi  kebutuhan  dasar  estetika,  pengembangan  sikap  dan  kepribadian  dan  sebagai determinan terhadap kecerdasan. Penelitian ini bertujuan untuk ini mengkaji penggunaan seni musik sebagai pendekatan pembelajaran dalam pembelajaran seni musik di sekolah dasar. Penelitian ini menggunakan pendekatan kualitatif. Metode yang digunakan adalah deskriptif bertujuan untuk mengamati dan menganalisis serta menggambarkan pentas seni sebagai pendekatan pembelajaran dalam pendidikan seni musik. Subjek penelitian ini adalah peserta didik sekolah dasar kelas III. Hasil penelitian menunjukan bahwa seni musik dapat meningkatkan keterlibatan peserta didik, memfasilitasi pemahaman konsep yang lebih mendalam, dan memperkaya pengalaman belajar secara keseluruhan. Melalui pendekatan interdisipliner yang menggabungkan teori pendidikan, psikologi, dan seni. Penelitian ini menunjukkan bahwa integrasi musik dalam proses pembelajaran tidak hanya meningkatkan motivasi dan partisipasi peserta didik untuk belajar, tetapi juga mengembangkan keterampilan kognitif dan sosial mereka. Hasil penelitian ini diharapkan dapat memberikan wawasan baru bagi pendidik dan praktisi untuk mengadopsi metode pembelajaran yang lebih kreatif dan efektif.
Finger Painting Multisensorik Sebagai Media Pembelajaran Inovatif Dalam Mengakselerasi Kreativitas Anak Usia Dini
Authors: Safira Triana , Aziz Thorik
Published: January 2025

Penelitian ini bertujuan untuk mengkaji penggunaan finger painting multisensorik sebagai media pembelajaran dalam mengakselerasi kreativitas anak usia dini di RA Ar-Rozzaq Bluto Sumenep. Penelitian menggunakan pendekatan kualitatif dengan desain studi kasus dengan melibatkan 15 anak usia 4-6 tahun, lima pendidik, dan orang tua siswa. Pengumpulan data dilakukan melalui observasi partisipatif, wawancara semi-terstruktur, dan dokumentasi selama 2 bulan. Hasil penelitian menunjukkan finger painting multisensorik efektif dalam mengembangkan kreativitas anak dalam aspek eksplorasi warna, pembentukan pola, koordinasi motorik halus, dan kepercayaan diri. Aktivitas ini juga mendukung perkembangan kognitif, bahasa, sosial, dan emosional anak. Meski menghadapi tantangan keterbatasan sarana, sekolah berhasil mengembangkan solusi melalui pemanfaatan sumber daya lokal dan sistem rotasi kelompok.
EFFECTS OF MATERNAL AGE ON THE RISK OF BIRTH DEFECTS IN ZAMFARA STATE NIGERIA USING LOGISTIC REGRESSIONS MODEL
Authors:   Department of Science Laboratory Technology Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria, . Abdullahi , . Aliyu ,   Department of Science Laboratory Technology Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria, . Lasisi ,   Department of Statistics Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria, O. Nurudeen ,   Department of Statistics Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria
Published: January 2025

Birth defects refer to physical or functional abnormalities that happen during prenatal period and can lead to physical or cognitive disabilities, or even death. The causes of birth defects are often complex and can involve genetic, environmental, nutritional, and socioeconomic factors. This research work aimed to examine the effects of the communication between age of maternal and parity on adverse pregnancy outcomes in Zamfara State, Nigeria. Maternal data were categorized according to age of the maternal and number of parity. The data were analyzed using logistic regression method of analysis and the data were analyzed using R-Statistical software and the results shown that the maternal age of 30 year above without parity having low birth defects, followed by maternal age of 20-29 year without parity and less than 20 year old maternal without parity was having higher chance of birth defects. Also, maternal age with birth parity, with year old; maternal age of 20-29 year old; and maternal age of year old were having the following chances of birth defects, 0.04, 0.02 and 0.004 respectively. More so, it was concluded that odds ratios was used to measure the effects and relationship between the age group, the study found that, maternal age year old has higher significant effect on birth defect outcome, with odds ratios of birth defect of 10 times higher than a maternal age year old, compared to maternal age of between 20 – 29 year old with the odds of birth defect of 5 times larger than of maternal age year old.
SMART RIDE BOOKING AND NAVIGATION SYSTEM
Authors:   Department of Electronics and Communication, Ahalia School of Engineering and Technology, Palakkad, Kerala- 678557, K S Akhil , Krishna KK Amith ,   Department of Electronics and Communication, Ahalia School of Engineering and Technology, Palakkad, Kerala- 678557, P Arjun ,   Department of Electronics and Communication, Ahalia School of Engineering and Technology, Palakkad, Kerala- 678557, P Aswath ,   Department of Electronics and Communication, Ahalia School of Engineering and Technology, Palakkad, Kerala- 678557, Jaseem J Muhammed ,   Department of Electronics and Communication, Ahalia School of Engineering and Technology, Palakkad, Kerala- 678557, Balamurugan Dr. V. ,   Department of Electronics and Communication, Ahalia School of Engineering and Technology, Palakkad, Kerala- 678557, P S Gayathri ,   Department of Electronics and Communication, Ahalia School of Engineering and Technology, Palakkad, Kerala- 678557
Published: January 2025

Most college students residing outside of their
homes never possess a vehicle, due to which they are
unable to go around between courses, cafeteria, ground,
Sports arena, etc. This bicycle rental scheme in GPS
tracking, QR scanning, online payment, locking and
unlocking automatically through android application
and all the features on a single android application. This
scheme also has an admin website where all the
information of user and bikes are stored also history of
bikes, payment and rides for security purposes. Bus
services is provided in the campus, but the time schedule
may not be ideal to the students. Thus, students may
prefer different modes of transport if they have a choice.
This alternative now takes the shape of bike sharing
services and is found to be very useful and affordable
way for navigation within the campus.
ON THE ISSUE OF INVALIDITY OF MARRIAGES (MARRIAGE UNIONS) REGISTERED ON THE TERRITORY OF THE RUSSIAN FEDERATION
Authors:   Mordovian State University. N.P. Ogarev, Saransk, Russian Federation, GALAEVA LYUDMILA A.
Published: January 2025

The article is devoted to the peculiarities of legal regulation of relations related to the establishment of facts that impede the conclusion and registration of marriages in the territory of the Russian Federation. The author analyzes the specifics of establishing such circumstances as «the presence of another registered marriage», including that of foreign citizens, as «recognition of a person as incompetent due to a mental disorder by virtue of a court decision» and highlights the legal problems of fictitious marriages complicated by a foreign element. It is significant that the study is devoted to the problems of introducing centralized information resources-registries-into this area of legal regulation of social relations. The goals and objectives of the stated research topic are resolved in the context of clarifying the legal issues of the systemic interpretation of family law and legislation on the legal status of foreign citizens in the Russian Federation. The author comes to the conclusion about the need for further improvement of the legislation determining the functioning of information resources-registries that allow promptly establishing facts that impede the conclusion of marriage or complicate its registration for purposes not related to the creation of a family.
Enhancing rabbit farming efficiency with integrated genomics and nutritional strategies
Authors: Goswami Naqash , Solomon Ahamba Ifeanyi , Kinkpe Lionel , Mujtaba Shah Ali , Xiangyang Ye , Song Bing , Dong Xianggui , Wang Shuhui , Ren Zhanjun
Published: January 2025

Rabbit farming plays a crucial role in meeting the global demand for high-quality meat and sustainable agricultural practices. In recent years, significant attention has been directed toward the integration of Genomic-Assisted Selection (GAS) and Precision Nutrition (PN) as synergistic strategies to improve productivity and animal welfare in rabbit production systems. This integration is particularly critical given the intricate interplay between genetic predispositions and nutritional demands in optimizing rabbit farming outcomes. The present review systematically explores the genetic diversity inherent to rabbit breeds, examines the impact of key genetic traits on productivity and welfare metrics, and highlights advancements in genomic research and associated tools within the context of rabbit breeding practices. By examining the importance of personalized nutrition tailored to individual rabbit requirements, as well as nutritional strategies to optimize productivity and longevity. In this regard, we provide essential understanding for farmers and researchers in the rabbit farming industry. Our goal is to provide a new perspective on the significance of this integrated approach and its implications for future practices and research in rabbit production, emphasizing the need for continued efforts to harness the full potential of genomics and nutrition in enhancing rabbit farming practices.
Exploring the potential of some natural indoles as antiviral agents: quantum chemical analysis, inverse molecular docking, and affinity calculations
Authors: Belal Amany , Abdou Aly , Miski Samar F. , Ali Mohamed A. M. , Ghamry Heba I. , Obaidullah Ahmad J. , Zaky Mohamed Y. , Hassan Ahmed H. E. , Roh Eun Joo , Al-Karmalawy Ahmed A. , Ibrahim Mona H.
Published: January 2025

Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections represent critical global health challenges due to the high morbidity and mortality associated with co-infections. HIV, the causative agent of acquired immunodeficiency syndrome (AIDS), infects 4,000 people daily, potentially leading to 1.2 million new cases by 2025, while HCV chronically affects 58 million people, causing cirrhosis and hepatocellular carcinoma. Indole-based compounds play a crucial role in antiviral drug development due to their “privileged scaffold” structure. This study investigates the antiviral potential of natural indoles, gardflorine A–C, derived from Gardneria multiflora Makino, a plant traditionally used to treat various ailments. We employed molecular docking, ADMET analysis, and computational techniques [frontier molecular orbital (FMO), natural bond orbital (NBO), and density functional theory (DFT)] to evaluate these compounds” potential as multi-target antiviral agents against HIV and HCV proteins.
Characteristics of meteorology and freeze-thaw in high-latitude cold regions: a case study in Da Xing’anling, Northeast China (2022–2023)
Authors: Shang Yunhu , Cao Yapeng , Li Guoyu , Gao Kai , Zhang Hang , Sheng Jie , Chen Dun , Lin Juncen
Published: January 2025

Meteorological characteristics and freeze-thaw processes are crucial indicators guiding regional economic development and practical production. The Da Xing’anling Mountains, serving as a transitional zone between continuous permafrost and seasonal frozen ground in northeastern China’s high latitudes, understanding the meteorological parameters and freeze-thaw development patterns in this region can significantly enhance the accuracy of permafrost zoning maps and validate climate simulation models. Based on meteorological and ground temperature monitoring data from 2022–2023, this study analyzed the meteorological characteristics and seasonal freeze-thaw processes of Jagdaqi (southern Da Xing’anling Mountains), which is located at the boundary between permafrost and seasonally frozen soil. The results indicate: (1) At a height of 5 m, the annual average temperature is 1.04°C. The air-freezing index and air-thawing index are −2318.95°Cd and 2698.52°Cd, respectively, categorizing it as a severe cold region. (2) The total annual precipitation is 397.1 mm, with summer rainfall accounting for 77.4% and winter rainfall only 11.3%. (3) The prevailing wind direction is from the northwest, accounting for approximately 47% of the total annual wind direction frequency. Annual wind speeds range from 0.045 to 10.33 m/s, with an average speed of 1.51 m/s. (4) At heights of 5 m and 10 m, the annual average relative humidity is 63.49% and 62.1%, respectively, reaching its lowest in May at 44.58% and 43.38%. (5) The study area is located in a seasonal frozen ground region, with maximum frost depths occurring in early to mid-March, ranging between 1.93–1.99 m, classified as middle-thick seasonally frozen ground. These findings hold valuable implications for ecological conservation, resource management, and engineering construction, enhancing the accuracy and applicability of models and permafrost zoning maps in this region.
Lipid metabolism indicators provide tools for the diagnosis of non-alcoholic fatty liver disease: results of a nationwide survey
Authors: Wang Yongxin , Fu Chang , Jin Hengwei , Yang Yibo , Li Xiaocong , Liu Kai
Published: January 2025

Background

Cardiometabolic index (CMI), visceral adiposity index (VAI), and lipid accumulation product (LAP) are lipid-related parameters that reflect central obesity, which is closely associated with the development of non-alcoholic fatty liver disease (NAFLD). The aim of this study is to investigate the effectiveness of these lipid-related parameters in diagnosing NAFLD and to compare their predictive abilities.

Methods

This population-based study extracted datasets from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. CMI, VAI, and LAP were included in the multivariate logistic model as both continuous and categorical variables to assess the relationship between different lipid-related parameters and NAFLD. To further elucidate this connection, we utilized restricted cubic splines and conducted subgroup analysis. Additionally, the receiver operating characteristics (ROC) curve was employed to evaluate the predictive effectiveness of CMI, VAI, and LAP for NAFLD.

Results

The study included 2,878 adults as the study population, of whom 1,263 participants were diagnosed with NAFLD. When lipid-related parameters were analyzed as continuous variables, they showed a positive correlation with NAFLD. The OR(95%CI) were 2.29(1.81,2.89) for CMI (per 1-unit), 1.40(1.28,1.52) for VAI (per 1-unit) and 1.15(1.11,1.20) for LAP (per 10-units). This correlation remains statistically significant when the lipid-related parameters are analyzed as categorical variables. In descending order of diagnostic capability for NAFLD, the AUC values are as follows: LAP (0.794), CMI (0.752), and VAI (0.719).

Conclusion

CMI, VAI, and LAP may be important clinical indicators for identifying NAFLD, with LAP demonstrating the best predictive ability among them.
Genomic deletions on 16p11.2 associated with severe obesity in Brazil
Authors: da Silva Assis Izadora Sthephanie , Salum Kaio Cezar Rodrigues , Felício Rafaela de Freitas Martins , Palhinha Lohanna , de Medeiros Abreu Gabriella , Silva Tamara , Mattos Fernanda Cristina Carvalho , Rosado Eliane Lopes , Zembrzuski Verônica Marques , Campos Junior Mario , Maya-Monteiro Clarissa Menezes , Cabello Pedro Hernán , Carneiro João Regis Ivar , Bozza Patrícia Torres , da Fonseca Ana Carolina Proença
Published: January 2025

Introduction

Genetic obesity is considered a rare disease, affecting up to 10% of patients with severe early-onset obesity. Over the past years, significant advances have been made; however, the majority of patients are misdiagnosed with polygenic obesity. Thus, this study aimed to identify deleterious copy number variations (CNVs) linked to obesity and explore the clinical phenotypes.

Method

The sample comprised 195 adults with severe obesity (BMI≥35kg/m2) who developed this phenotype during childhood or adolescence. We investigated the CNV using Multiplex Ligation-dependent Probe Amplification [MLPA] and real-time PCR. Chromosomal microarray analysis was used to assess the extent of genomic alterations.

Results

One patient showed a ~206 kb deletion in the distal of the 16p11.2 region, encompassing twelve genes. The gene linked to the development of severe obesity was SH2B1. This alteration was found in a male patient with metabolic syndrome (MS), and hypertension. Two patients exhibited a large deletion in the proximal of the 16p11.2 region. One patient showed a ~534 kb deletion without twenty-nine genes. This female patient had hypertension and bronchitis. The other patient presented a ~598 kb deletion of the proximal 16p11.2 region, including thirty-two genes. This female patient exhibited MS, and moderate binge-eating disorder.

Conclusion

Our study showed three genomic deletions at the 16p11.2 region in patients with severe obesity from Brazil. These results support the clinical utility of genetic testing to identify patients with the genetic form of obesity who may benefit from specific medical treatment, family genetic counseling, and targeted therapeutic intervention.
Evaluating the influence of anti-PD-1 immunotherapy combined with IMRT on thyroid dysfunction in nasopharyngeal carcinoma
Authors: Chen Liqianqi , Li Zihuang , Li Xianming , Wu Shihai , Gong Long , Xu Gang , Chen Shanyi , Zhang Yucong
Published: January 2025

Background

Immunotherapy represents a major breakthrough in malignant tumor treatment in recent years. Anti-PD-1 immunotherapy has significantly prolonged Event-free Survival (EFS) in Nasopharyngeal Carcinoma (NPC). However, its potent anti-tumor effects can also attack normal tissues and organs, leading to immune-related adverse effects (irAE), with the thyroid being one of the most commonly affected organs. This study aims to analyze the incidence and related factors of thyroid dysfunction in NPC patients receiving anti-PD-1 immunotherapy with/without Intensity-modulated radiotherapy (IMRT), and further explore whether radiotherapy interacts with thyroid immune-related adverse reactions.

Methods

108 NPC patients receiving immunotherapy combined with chemotherapy or chemoradiotherapy were retrospectively included. Data collected included smoking status, BMI, presence of thyroid nodules, staging, treatment modality, thyroid mean dose (Dmean), percentage of thyroid volume receiving more than x Gy, pituitary mean dose (Dmean), and TSH and FT4 levels per cycle. T-tests, rank-sum tests, multivariate logistic regression analysis, ROC curves, and Cox proportional hazards models were used to evaluate the effects of anti-PD-1 immunotherapy combined with chemoradiotherapy on thyroid function.

Results

Patients with pre-treatment smoking history, thyroid nodules, and cervical lymph node metastasis were more likely to develop thyroid dysfunction (P<0.05). During treatment, 81 patients developed varying degrees of thyroid dysfunction. Subclinical hyperthyroidism (33.9%) was most common in the immunotherapy plus chemoradiotherapy group, while subclinical hypothyroidism (23.9%) was most common in the immunotherapy plus chemotherapy group. Compared to the immunotherapy plus chemotherapy group, the immunotherapy plus chemoradiotherapy group showed higher incidence and severity of hyperthyroidism (median peak FT4 concentration: 19.11 pmol/L vs 16.21 pmol/L) (P=0.001). The immunotherapy plus chemoradiotherapy group showed lower incidence but increased severity of hypothyroidism compared to the immunotherapy plus chemotherapy group, though these differences were not statistically significant.

Conclusion

NPC patients with smoking history, thyroid nodules, and cervical lymph node metastasis have significantly increased risk of thyroid dysfunction when receiving anti-PD-1 immunotherapy combined with IMRT. The combination of anti-PD-1 immunotherapy and IMRT increases both the incidence and severity of thyroid dysfunction.
Severe Guillain-Barré syndrome with concurrent optic neuritis in a pediatric patient: a case report
Authors: Xue Xin , Bao Yingcun , Yu Yakun , Li Qun , Liu Mei , Li Xiaoling
Published: January 2025

Introduction

Guillain-Barré syndrome (GBS) is a rare, immune-mediated polyneuropathy primarily affecting the peripheral nervous system. Diagnosis is often supported by neuroconduction studies showing polyradiculoneuropathy and cerebrospinal fluid (CSF) analysis revealing albumin-cytological dissociation. However, these features may not appear in the early stages, leading to potential misdiagnosis. The central nervous system (CNS) is generally not affected due to differences in antigen expression, optic neuritis (ON), a demyelinating inflammation of the optic nerve, occasionally co-occurs with GBS as a rare variant. Although GBS can manifest with various neurological symptoms, the co-occurrence of optic neuritis (ON) is rare, especially in pediatric cases. This report documents the first known case in China of a child with severe GBS complicated by ON, which developed following an upper respiratory infection.

Case presentation

A 14-year-old male presented with acute progressive quadriparesis and visual impairment following a febrile illness. On admission, he displayed severe respiratory and autonomic instability requiring mechanical ventilation. Neurological examination revealed flaccid paralysis of all four limbs with absent reflexes, along with bilateral optic neuritis, confirmed by MRI showing inflammation of the optic nerve. Initial cerebrospinal fluid (CSF) analysis was normal, but subsequent testing revealed elevated protein levels typical of GBS. Neurophysiological studies indicated widespread demyelinating and axonal damage.

Interventions and outcomes

The patient received intravenous immunoglobulin (IVIG) therapy, high-dose corticosteroids, and, given the severe progression, rituximab. Despite initial worsening, gradual improvement in muscle strength and visual acuity was observed over several weeks. At three months, the patient was discharged with significantly restored function, with muscle strength nearing baseline and partial visual recovery.

Conclusion

This case highlights the clinical complexity of GBS with ON in pediatric patients, emphasizing the importance of timely immunomodulatory treatment. It also underscores the need for awareness of overlapping central and peripheral autoimmune neuropathies to improve diagnostic accuracy and patient outcomes.
Antibodies against neuronal surface antigens in acute stroke: a systematic review and meta-analysis
Authors: Paolucci Matteo , Zini Andrea , Morelli Luana , Liguori Rocco , Giannoccaro Maria Pia
Published: January 2025

Background

Antibodies against neuronal surface antigens (NSA-Abs), particularly against the NMDA receptor (NMDAR-Ab), have been reported in acute stroke patients (ASP). However, their role in stroke is far from being understood.

Methods

We conducted a systematic review and meta-analysis to investigate: 1) the frequency of NSA-Abs in patients with acute stroke compared to controls; 2) the de novo appearance of NSA-Abs after stroke; and 3) their effects on the clinical outcome.

Results

We included nine studies in the qualitative analysis and seven in the quantitative analysis. Analyses were restricted to NMDAR-Abs due to the lack of data about other NSA-Abs. Considering only studies that adopted a cell-based assay, IgA-IgM NMDAR-Abs isotypes (but not the IgG) were found more frequently in patients with acute stroke (OR 2.69, 95% CI 2.00–3.62, I2 = 4%). There was no de novo NMDAR-Abs formation after stroke. There was no statistical difference in mean discharge/day–7 NIHSS (SMD 0.21, 95% CI -1.10–1.52, I2 = 84%) and 3–12-month mRS (SMD 0.38, 95% CI -0.56-1.32, I2 = 78%) between patients with stroke with and without NMDAR-Abs seropositivity.

Conclusions

Serum IgA/IgM NMDAR-Abs are more frequent in patients with stroke than controls. Due to several methodological issues, these findings should be interpreted cautiously. Additional, methodologically robust studies are needed to clarify the prevalence and significance of NMDAR-Abs in patients with stroke.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022241278#:~:text=https%3A//www.crd.york.ac.uk/prospero/display_record.php%3FID%3DCRD42022241278, identifier CRD42022241278.
Orbital cycle records in shallow unconsolidated sediments: implications for global carbon cycle and hydrate system evolution in deep-sea area sediments of the Qiongdongnan Basin
Authors: Dong Yang , Wang Ren , Liang Jinqiang , He Yulin , Ren Jinfeng , Shi Wanzhong , Wei Xiaosong , Du Hao , Xie Xiangyang , Busbey Arthur B.
Published: January 2025

Introduction

Milankovitch theory has extensive application in sequence stratigraphy and the establishment of time scales. However, it is rarely applied to shallow strata rich in hydrates. Cyclostratigraphic analysis of the Quaternary unconsolidated sediments can help identify climate and sea level changes that correspond to orbital cycles and improve our understanding of the dynamic evolution of hydrates.

Methods

Using the natural gamma-ray log data from the deepwater area well W01 in the Qiongdongnan Basin, Milankovitch cycle analysis was conducted to identify the primary astronomical period in W01. Anchored to existing AMS-14 C age from bivalve shell as reference point, an astronomical age scale of W01 was established. Simultaneously, through the analyses of major trace elements and total organic carbon content (TOC) in sediment samples, how astronomical orbital cycles influenced past environmental conditions. Furthermore, employing sedimentary noise models, the relative sea level change of well W01 was reconstructed.

Results

Sedimentary cycles of 27.34 m and 6.73 m were identified in the GR data from well W01, corresponding to orbital periods of 405 kyr and 100 kyr eccentricity, with a duration of approximately 2.5 Myr. The spectral analysis of paleoenvironmental proxies reveals a sedimentary cycle of approximately 27 m, while the sedimentary noise model reconstructs the fluctuating rise in sea level change. An obliquity modulation period of approximately 170 kyr was identified in the TOC data, which may reflect the combined effects of obliquity and other orbital parameters.

Discussion

Spectral analysis of paleoenvironmental indicators showed that long eccentricity cycle had varying degrees of influence on changes in paleoclimate, paleosalinity, and paleoredox conditions. Additionally, a 1.2 Myr cycle was identified as a significant factor influencing sea level changes during the early Pleistocene in the South China Sea (SCS). In addition, it is confirmed that the dominant period of the glacial-interglacial cycle in the SCS from 0.6 Ma to the present is 100 kyr period. Synthesize the above analysis, during phases of low amplitude in the 405 kyr cycle or minimum value of the 100 kyr cycle, which are associated with lower temperature, conditions become more conducive to hydrate accumulation.
Role of crevice size induced microenvironment variation within the gap in initiating crevice corrosion of 201 stainless steel
Authors: Ge Hao-Jing , Bai Yi-Han , Zhang Hang , Yuan Hao-Ran , Zhu Ze-Jie , Liu Pan , Zeng Yun-Xiong , Wang Jiang-Ying
Published: January 2025

The effects of the real-time changes in the microenvironment within the crevice caused by the change in crevice size on the induction of crevice corrosion of 201 stainless steel (201-SS) in 1 M (pH = 4.00) NaCl solution were evaluated using conventional methods and scanning electrochemical microscopy (SECM) containing potentiometric probes. Results show that a decrease in pH and an increase in the Cl− concentration within the gap are the pivotal determinants of crevice corrosion initiation. A narrower crevice creates a more aggressive corrosive environment. After immersion for 48 h, the corresponding pH values at the mouths of crevice with widths of 100, 250, 400 and 550 μm dropped to 1.64, 2.26, 2.73 and 2.88, respectively. The crevice size affects the accumulation rate of erosive ions and the initiation time of pits corrosion within the crevice, through the volume and diffusion effect. The coupling effect of the decrease in pH value and the increase in concentration of chloride ions is the main driver for the negative shift of the open circuit potential (OCP) and corrosion potential of 201-SS.
Associations between systemic immune-inflammatory index and visceral adipose tissue area: results of a national survey
Authors: Liao Yayun , Zhou Kejian , Lin Baoquan , Deng Shan , Weng Baohui , Pan Liya
Published: January 2025

Background

Global health issues related to obesity are growing. Visceral adipose tissue (VAT) significantly contributes to complications associated with obesity. Reducing adipose tissue accumulation can improves inflammation. However, it is still unknown how the systemic immune-inflammation index (SII) and VAT area are related.

Methods

With the help of multivariate linear regression and smooth curve fitting, the relationship between SII and VAT area was explored with data from the 2013 and 2014 National Health and Nutrition Examination Survey (NHANES). Analyzing subgroups and testing for interaction were used to investigate whether the relationship was accurate across demographics.

Results

From 20 to 59 years of age, 3,290 individuals were observed to have a positive correlation between SII and VAT area. In accordance with the fully adjusted model, the VAT area increased by 9.34 cm2 for every unit increase in log SII [β = 9.34, 95% CI (4.02, 14.67)]. In the highest quartile of SII, the VAT area was 5.46 cm2 [β = 5.46, 95% CI (2.21, 8.71)] higher than that in the lowest quartile. Additionally, the population that was overweight or obese showed a stronger positive correlation.

Conclusion

SII has a positive correlation with VAT area in US adults. SII may be valuable in clinical applications to evaluate the severity of VAT area.
Clinical applications and research progress of totally implantable venous access ports: a literature review
Authors: Huang Xiao-Min , Li Xia , Deng Jie , Chen Jiong , Qian Liang
Published: January 2025

Totally implantable venous access port (TIVAP), a novel intravenous infusion system that is used for long-term intravenous treatment, has become increasingly popular among cancer patients undergoing chemotherapy and other patients requiring long-term intravenous infusions. This technology has been introduced into clinical practice in China, with successful results. Nevertheless, there are still certain problems; for instance, China has not set up a specialized regulatory agency to oversee research and set guidelines for the comprehensive life-cycle management of TIVAP. Additionally, there exists a disparity in standardized operations and complication management related to TIVAP, which has resulted in variable outcomes, complications, and patient satisfaction with TIVAP implantation across different medical units in China. Therefore, this article aims to provide a systematic overview of the clinical applications and maintenance of TIVAP, both domestically and internationally. Furthermore, this review investigated the latest strategies and associated research on TIVAP implantation and complication management, aiming to provide a basis for standardized surgical and maintenance procedures, protocols to minimize complications, and approaches for enhancing the overall quality of life for patients.
Resistance spikes of NiO/ZnO heterostructures in magnetic field
Authors: Sun Yu-Ze , Qiu Li-Peng , Gao Shi-Long , Cao Shi-Ze , Wang Shuai-Jie , Han Wen-Peng , Zhang Jun , Long Yun-Ze
Published: January 2025

NiO/ZnO semiconductor heterostructures were fabricated via electrospinning to investigate their resistance behavior under varying magnetic fields. The resistance of the heterostructures was measured at different temperatures and in magnetic fields of varying strength and direction. Resistance spikes of 1.3%, 5.2%, and 10.7% were observed at 300 K, 290 K, and 280 K, respectively. These resistance variations were found to be influenced by both the magnetic field magnitude and direction, as well as light illumination. The observed phenomena are attributed to the interaction between the heterojunction and the magnetic field, alongside changes in spin electron orientation. This study demonstrates the potential of combining heterostructures and magnetic fields to modulate resistance, offering promising applications for optoelectronic and magnetoelectronic devices.
DFMA: an improved DeepLabv3+ based on FasterNet, multi-receptive field, and attention mechanism for high-throughput phenotyping of seedlings
Authors: Jia Liangquan , Wang Tao , Li Xiangge , Gao Lu , Yu Qiangguo , Zhang Xincheng , Ma Shanlin
Published: January 2025

With the rapid advancement of plant phenotyping research, understanding plant genetic information and growth trends has become crucial. Measuring seedling length is a key criterion for assessing seed viability, but traditional ruler-based methods are time-consuming and labor-intensive. To address these limitations, we propose an efficient deep learning approach to enhance plant seedling phenotyping analysis. We improved the DeepLabv3+ model, naming it DFMA, and introduced a novel ASPP structure, PSPA-ASPP. On our self-constructed rice seedling dataset, the model achieved a mean Intersection over Union (mIoU) of 81.72%. On publicly available datasets, including Arabidopsis thaliana, Brachypodium distachyon, and Sinapis alba, detection scores reached 87.69%, 91.07%, and 66.44%, respectively, outperforming existing models. The model generates detailed segmentation masks, capturing structures such as the embryonic shoot, axis, and root, while a seedling length measurement algorithm provides precise parameters for component development. This approach offers a comprehensive, automated solution, improving phenotyping analysis efficiency and addressing the challenges of traditional methods.