bluuebunny/crossref_metadata_2025 huggingface dataset:
Health workers’ perspectives on the occurrence and management of antimicrobial resistance at the human-animal-environment interface in Uganda
Authors: Muleme James , Kibira Simon P.S. , Ssempebwa John C. , Mugambe Richard K. , Kankya Clovice , Munyeme Musso , Kisaka Stevens , Isunju John Bosco , Ninsiima Lesley Rose , Musoke David
Published: January 2023

Background
The role of human, animal and environmental health workers is increasingly being recognized and linked to the emergence and transmission of antimicrobial resistance (AMR). Little has been done in low and middle-income countries despite the seriousness of this public health challenge. Our study explored the perspectives of health workers on the occurrence, transmission, and management of AMR at the human-animal-environment interface.
Methods
We conducted a descriptive qualitative study within Wakiso district, central Uganda between August and October 2022, using focus group discussions (4) with village health teams (VHTs) and key informant interviews (12) with other cadres of health workers. Data were managed in NVivo 12 and analyzed using thematic network analysis exploiting both deductive and inductive approaches.
Findings:
Animal health workers had better knowledge of AMR occurrence compared to their counterparts from the human and environmental health sectors. VHTs had a limited understanding of the AMR concept, even though they believed that drug-resistant infections were a growing concern in the community. Advancement in technology was viewed as being both a facilitator and a barrier to AMR occurrence and management. Cultural norms underlying animal production and close interactions between humans and animals were reported as key drivers for AMR spillover and amplification. Laxity in policy implementation, unskilled human resource, and weak surveillance systems for AMR were reported to be the underlying gaps in its management. Most participants advocated for a One Health strategy in combatting AMR at a community level.
Conclusion
Culture-driven solutions, diagnosis before treatment, more sensitization of community health workers, and improved regulation of drug use as well as multi-sectoral collaborations may create a suitable environment for the implementation of one-health approaches in the management of AMR.
Higher incidence of new atrial fibrillation in hospitalised COVID-19 patients compared to lower respiratory tract infection, however, less patients anticoagulated at discharge
Authors: Induruwa Isuru , Cattermole Elizabeth , Paisey Christopher , Ne Colver Ken Howe , Khadjooi Kayvan
Published: January 2023

Background
Infection is a well-known contributor to developing cardiac arrythmias such as atrial fibrillation (AF), which contributes to over 25% of all ischaemic stroke. We wanted to quantify the incidence of first-diagnosed (new) AF (nAF) during hospitalisation with COVID-19 compared to a lower respiratory tract infection (LRTI), as well as compare anticoagulation rates at discharge, reasons for non-prescription of anticoagulation and determine factors associated with developing nAF with COVID-19.
Methods
We analysed a comprehensive hospital coding database on patients hospitalised due to COVID-19+/-AF or LRTI +/-AF, between 1/3/2020 and 31/12/2020 at a large tertiary hospital in the UK. Incidence of nAF during COVID-19 or LRTI, and the proportions of nAF patients discharged on anticoagulation and reasons for non-prescription from both cohorts were quantified.
Results
2243 patients were hospitalised with LRTI and 488 with COVID-19. nAF was diagnosed in significantly more COVID-19 patients compared to LRTI (7.0% vs 3.6%, P=0.003). However, significantly less COVID-19 patients were discharged on anticoagulation compared to LRTI (19.2% vs 55.9%, P=0.003) despite similar CHA2DS2-VASc scores, and lower ORBIT scores. 14/26 LRTI +nAF patients had documented contraindication not to be anticoagulated, whereas only 1/12 patients with COVID-19 +nAF did. Patients who developed nAF during hospitalisation with COVID-19 were older (P<0.001), had pre-existing congestive cardiac failure (P=0.004), ischaemic heart disease (IHD) or peripheral vascular disease (PVD) (P<0.001), and a higher CHA2DS2-VASc score (P=0.02). Older age (Odds ratio (OR) 1.03, P=0.007) and IHD/PVD (OR 2.87, P=0.01) increased the odds of developing nAF with COVID-19.
Conclusion
Higher incidence of nAF and lower anticoagulation rates in COVID-19 patients were observed, compared to LRTI. A larger proportion of COVID-19 +nAF patients did not have a clear documented reason for non-prescription of anticoagulation in their notes. Whilst we await further research and clear guidelines, a pragmatic approach would be to holistically consider anticoagulation in all patients with COVID-19+nAF and a high ischaemic stroke risk.
Resveratrol Prevents Apoptosis, allowing Preosteoblastic MC3T3-E1 cells to Proliferate and Differentiate
Authors: Cai Weiye , Song Chao , Liu Fei , Chen Rui , Gao Silong , Guo Daru , Mou Ning , Xiong Zhongwei , Liu Zongchao
Published: January 2023

The purpose of this study was to investigate the mechanism by which resveratrol (Res) inhibits apoptosis and promotes proliferation and differentiation of preosteoblastic MC3T3-E1, laying the groundwork for the treatment of osteoporosis (OP). The TCMSP database was used to find the gene targets for Res. The GeneCards database yielded the gene targets for OP. Following the discovery of potential gene targets, GO, KEGG, and Reactome enrichment analysis were conducted. Verifying the major proteins involved in apoptosis can bind to Res using molecular docking. CCK8 measured the proliferative activity of mouse preosteoblasts in each group following Res intervention. Alkaline phosphatase staining (ALP) and alizarin red staining to measure the degree of osteogenic differentiation. RT-qPCR to determine the expression levels of Runx2 and OPG genes for osteogenic differentiation ability of cells. Western blot to measure the degree of apoptosis-related protein activity in each group following Res intervention. The biological processes investigated for GO of Res therapeutic OP involved in cytokine-mediated signaling pathway, negative regulation of apoptotic process, Aging, extrinsic apoptotic signaling pathway in absence of ligand, according to potential therapeutic target enrichment study. Apoptosis, FoxO signaling pathway, and TNF signaling pathway are the primary KEGG signaling pathways. Recactome pathways are primarily engaged in Programmed Cell Death, Apoptosis, Intrinsic Apoptotic Pathway, and Caspase activation via extrinsic apoptotic signaling pathways. This research established a new approach for Res treatment of OP by demonstrating how Res controls the apoptosis-related proteins TNF, IL6, and CASP3 to suppress osteoblast death and increase osteoclastogenesis.
Phase I clinical trial of CD19 CAR-T cells expressing CXCR5 protein for the treatment of relapsed or refractory B-cell lymphoma
Authors: Wang Jiaxi , Jiang Yirong , Luo Min , Lu Wenyi , He Jixiang , Zhang Meng , Yao Zhuoxin , Jin Xin , Xiao Xia , Chen Jianhang , Li Guangchao , Ding Wen , Zhang Zhiyin , Zhao Mingfeng
Published: January 2023

Background
The difficulty of CD19 CAR-T cells entering solid tumors is one of the reasons for its poor efficacy in the treatment of lymphoma.The chemokine CXCL13 secreted by stromal cells of the lymph nodes, induces the homing of B and T lymphocytes who express its receptor CXCR5. Pre-clinical trials have shown that CD19 CAR-T cells expressing CXCR5 could increase its migration to the tumor microenvironment and enhance the anti-tumor function of CD19 CAR-T cells.
Methods
We generated a novel anti-CD19 CAR-expressing CXCR5 protein. Then, we conducted a phase I clinical trial to evaluate safety and efficacy of CXCR5 CD19 CAR-T cells in the treatment of relapsed or refractory (R/R) B-cell lymphoma.
Results
We recruited 10 patients with R/R B-cell lymphoma undergoing CXCR5 CD19 CAR-T cells therapy. The objective response rate was 80%, complete response rate was 50%. The progression-free survival of these ten patients was 5 months (95% CI 1.02-8.98 months), while the median overall survival was 17.76 months (95% CI 13.54-21.98 months). The incidence of grade 1 and grade 2 cytokine release syndrome (CRS) was 70% and 20%, respectively. No patient experienced grade 3 or higher level of CRS, neurotoxicity and infusion-related dose toxicity.
Conclusions
In this study, we suggest that the results obtained here can pave the way for CXCR5 CD19 CAR-T cells to be investigated in a trial with broader patient populations.
Trial registration
The trials were registered at www.chictr.org.cn as ChiCTR2100052677 and ChiCTR1900028692.
Influence of molybdenum and organic sources of copper and sulfur on performance and blood mineral concentration in lambs
Authors: Conti Renata M.C. , Silva Thiago H. , Guimarães Iuli C.S.B. , Bezerra Helena V.A. , Netto Arlindo Saran , Rodrigues Paulo H.M. , Pacheco José C.G. , Zanetti Marcus A.
Published: January 2023

This study aimed to evaluate the effects of molybdenum (Mo) and organic and inorganic sources of copper (Cu) and sulfur (S) on performance and blood concentration of these minerals in lambs. Forty male non-castrated crossbred Dorper x Santa Inês lambs (20 ± 1.2 kg of body weight and 90 ± 2 d of age) were randomly allocated into one of the 10 following treatments: T0) control, basal diet; T1) Mo; T2) inorganic Cu and inorganic S; T3) inorganic Cu and organic S; T4) organic Cu and inorganic S; T5) organic Cu and organic S; T6) Mo plus inorganic Cu and inorganic S; T7) Mo plus inorganic Cu and organic S; T8) Mo plus organic Cu and inorganic S; T9) Mo plus organic Cu and organic S. The animals were kept in individual pens and received a total mixed ration during 84 days. Body weight and blood sampling was performed every 28 days. All animals were slaughtered after 84 days and carcass traits were evaluated. No effects of treatments were observed on body weight and carcass traits. Dietary molybdenum and sulfur-supplemented animals had reduced serum concentrations of copper and ceruloplasmin. Also, an interaction among Mo x Cu sources x S sources was detected for both copper and ceruloplasmin serum concentrations. Organic sources of Cu and S led to increased serum concentration of S. Further, Mo supplementation influenced positively its blood concentration.
Culturally sensitive translation of the Perceived Stress Scale and the Multi-dimensional Scale of Perceived Social Support into Marathi language
Authors: Shidhaye Rahul , Thanage Chitra , Bangal Vidyadhar , Behere Nilam Shivajirao , Pulate Vandana , Tambe Sonali , Tilekar Swanand
Published: January 2023

Purpose: Perceived Stress Scale (PSS) and the Multi-dimensional Scale of Perceived Social Support (MSPSS) are widely used globally (and in India) to assess the perceived stress and perceived social support respectively. Local language versions of these tools have been validated in different parts of the world and some Indian languages, but these studies have been carried out in populations outside India. Translation and validation of these tools in Marathi language is not yet undertaken.
Methods: We used the following steps to translate and adapt the PSS and the MSPSS into Marathi: forward translation, feedback from the bilingual committee, cognitive interviewing and pre-testing, backward translation, comparison of the original English versions with the back-translated English versions, and the assessment of conceptual and operational equivalence which was done using the Pearson’s correlation coefficients and the Bland-Altman approach.
Results: There was a very high correlation between the English and the Marathi version of the PSS (0.97) and the MSPSS (0.98). For the self and interviewer administered versions, Pearson’s Correlation Coefficient was slightly lower for the PSS (0.76, p=0.01), but for MSPSS it was 0.97 (p<0.001). The agreement between the two language versions of both the scales and the self and interviewer-administered versions was also established using the Bland-Altman plots.
Conclusion: The outputs of this study, i.e., the self and interviewer-administered Marathi language versions of the PSS and the MSPSS are based on a systematic approach of culturally sensitive translation, and these can now be further used for assessment of their psychometric validity.
1,400 Years of Climate Change in the Northern Hemisphere
Authors: Morando Marco
Published: January 2023

Anthropogenic Global Warming is the Climate Change main cause. Nevertheless, several authors indicated the solar activity and the Atlantic Multi-decadal Oscillation variation as additional forcing. This article considers the amplification of the solar radiation and of the Atlantic Multi-decadal Oscillation’s variation, via sea ice cover albedo feedbacks in the Arctic regions, as forcing Climate change in complement to Anthropogenic Global Warming. A physical model, using the sunspot number count and the Atlantic Multi-decadal Oscillation index as inputs, simulates the average global temperature anomaly and the Arctic Sea Ice Extension for the past twelve centuries. This model represents innovative progress in understanding how existing studies on Arctic Sea ice’s albedo feedbacks can help complement the Anthropogenic Global Warming models, thus helping to define more precise models for future climate change. In addition, the North Atlantic Oscillation index across 1,200 years is determined and, through its correlation with temperature and precipitation anomaly, the climate history of 15 different European and Northern Hemisphere regions is modelled. The results are then compared with quantitative and qualitative benchmarks from the literature, to evaluate their level of accuracy in simulating the historical data. For purpose of simplicity, the model does not consider anthropogenic global warming. Nevertheless, the natural forcing described in this article shall be considered complementary to anthropogenic global warming effects. Manmade forcing will be included in a future model to be developed by the author.
Virtual Reality in der Schule
Authors: Schäfer Caterina , Rohse Dorina , Gittinger Micha , Wiesche David
Published: January 2023

Dieser Beitrag präsentiert und diskutiert die Ergebnisse aus vier interdisziplinären Ratingkonferenzen, in denen Schüler:innen, Lehrpersonen und Expert:innen aus Entwicklung Medienpädagogik und Wissenschaft Bedenken und Potenziale des schulischen Einsatzes von Virtual Reality (VR) diskutieren. VR ist, obwohl zunehmend als Bildungstechnologie anerkannt, in der Schule noch nicht grundständig angekommen. Anhand der inhaltlich strukturierenden qualitativen Inhaltsanalyse nach Kuckartz und induktiver Kategorienermittlung werden aus den Daten vier Hauptkategorien abgeleitet. Es fehlt laut den Akteur:innen an technischer Ausstattung sowie Erfahrungen, Ideen und erprobten Konzepten für den schulischen Unterricht. Einem Mehraufwand steht ein schwer einzuschätzender Mehrwert entgegen. Gleichzeitig attestieren die Teilnehmenden VR-gestützten Lernumgebungen eine Vielzahl an Potenzialen wie immersives Lernen, barrierefreie Zugänge und Möglichkeiten für eine differenzierte Unterrichtsgestaltung. Der Beitrag zeigt auch, dass weder der wissenschaftliche Diskurs noch die teilnehmenden Akteur:innen bisher konkrete Aspekte eines verkörperten Lernens in, mit und durch VR (Extended Embodied Education) beachten. Eine Zusammenarbeit der im Schulkontext beteiligten Akteur:innen ist im Sinne einer Netzwerkarbeit zur Implementierung von VR in der Schule erstrebenswert.
Development of identification criteria for fruit vodkas (Part 1. Sample preparation ways)
Authors: Krikunova L. N. , Ulyanova E. V. , Tomgorova S. M. , Andrievskaya D. V. , Trofimchenko V. A.
Published: January 2023

The  development of reliable identification criteria for various  types of foods,  including fruit  vodkas,  is one  of the top-priority directions of scientific research in the field of quality control. The review examines different approaches to solution to a problem of searching identification criteria for fruit vodkas that will allow differentiating products by a type of fruit  raw materials, their grade  and region of origin.  To this  end, instrumental methods of analysis were used, including spectral, high performance liquid chromatography (HPLC) and gas chromatography coupled to mass  spectrometry (GC–MS) as the  main  method. When  detecting minor  aroma-forming substances using  the  latter method, it is necessary, first  of all, to  carry  out  the  special  sample preparation that includes extraction and  concentration of target substances. The  present review  examines three main  types of sample preparation (liquid  extraction, solid-phase extraction, supercritical fluid extraction) and  modifications of these methods. Their  comparative analysis was carried out  with  respect to  labor  intensity, extraction effectiveness, volatile aroma-forming compounds significantly different by polarity, reproducibility and  sustainability. It has been  shown  that a type of sample preparation affects  reproducibility and sensitivity of an instrumental analytic method, which is especially important for identification of some  minor  compounds, which concentration can be regarded as indicators for identification of fruit  raw materials. It has been  concluded that among  the  examined methods of sample preparation, the most  promising for the development of identification criteria for fruit vodkas is headspace solid-phase microextraction (HS-SPME) as this  method is highly  effective in terms of extraction of target components including minor.
Study of the composition of the residual microflora of milk after pasteurization
Authors: Sviridenko G. M. , Komarova T. V. , Uskova E. E.
Published: January 2023

The article presents the results of studies of the composition of the residual microflora of pasteurized milk, depending on the bacterial landscape and the initial contamination of raw milk. The thermal stability of test  cultures of microorganisms that significantly affect the  quality and  storage capacity of fermented dairy products has been  studied. To study  the  composition of the  residual microflora of milk after  pasteurization, sterile milk was infected with  test  cultures of microorganisms at doses  from  101 CFU/cm3 to 107 CFU/cm3. After infection, the  milk was pasteurized at temperatures of (72 ± 1) °C and  (80 ± 1) °C with  a holding time  of 10–20  seconds. The detection and  enumeration of microorganisms was carried out  by standardized microbiological methods. Microorganisms were identified by visual assessment of dominant colonies and cell morphology in micropreparations. The thermal stability of microorganisms important for dairy products, in particular cheeses, the source of which  is raw milk, has been  studied. It has been  established that of the  coccal  forms,  the  greatest risks are associated with  enterococci. Escherichia coli at  infection doses  above 106 CFU/cm3 partially retains viability both  at low-temperature and  at high-temperature pasteurization. Pasteurization temperatures do not have  a lethal effect on spore  bacilli, their number in pasteurized milk does not decrease, regardless of the  initial dose of infection. Low-temperature pasteurization activates the process of clostridial spore  germination. The ability to reactivate cells after  thermal shock was observed in Escherichia coli, Staphylococcus aureus, Pseudomonas, and  mold  fungi.  Thus,  the  residual microflora of milk  subjected to  low-temperature pasteurization is represented by enterococci, thermophilic streptococci, micrococci, staphylococci, asporogenous bacilli  and  spore bacteria. The above microorganisms constitute  the  residual microflora of pasteurized milk and are involved in the  maturation of cheeses, determining their quality and  safety,  [as well as] affecting the  storage capacity of the finished product.
A Systematic Literature Review on SOTA Machine learning-supported Computer Vision Approaches to Image Enhancement
Authors: Klaiber Marco , Klopfer Jonas
Published: January 2023

Image enhancement as a problem-oriented process of optimizing visual appearances to provide easier-toprocess input to automated image processing techniques is an area that will consistently be a companion to computer vision despite advances in image acquisition and its relevance continues to grow. For our systematic literature review, we consider the major peer-reviewed journals and conference papers on the state of the art in machine learning-based computer vision approaches for image enhancement. We describe the image enhancement methods relevant to our work and introduce the machine learning models used. We then provide a comprehensive overview of the different application areas and formulate research gaps for future scientific work on machine learning based computer vision approaches for image enhancement based on our results
Sentiment Analysis of COVID-19 Vaccines in Indonesia on Twitter Using Pre-Trained and Self-Training Word Embeddings
Authors: Agustiningsih Kartikasari Kusuma , Utami Ema , Alsyaibani Muhammad Altoumi
Published: January 2023

Sentiment analysis regarding the COVID-19 vaccine can be obtained from social media because users usually express their opinions through social media. One of the social media that is most often used by Indonesian people to express their opinion is Twitter. The method used in this research is Bidirectional LSTM which will be combined with word embedding. In this study, fastText and GloVe were tested as word embedding. We created 8 test scenarios to inspect performance of the word embeddings, using both pre-trained and self-trained word embedding vectors. Dataset gathered from Twitter was prepared as stemmed dataset and unstemmed dataset. The highest accuracy from GloVe scenario group was generated by model which used self-trained GloVe and trained on unstemmed dataset. The accuracy reached 92.5%. On the other hand, the highest accuracy from fastText scenario group generated by model which used self-trained fastText and trained on stemmed dataset. The accuracy reached 92.3%. In other scenarios that used pre-trained embedding vector, the accuracy was quite lower than scenarios that used self-trained embedding vector, because the pre-trained embedding data was trained using the Wikipedia corpus which contains standard and well-structured language while the dataset used in this study came from Twitter which contains non-standard sentences. Even though the dataset was processed using stemming and slang words dictionary, the pre-trained embedding still can not recognize several words from our dataset.
Epidemic Data Analysis of Three Variants of COVID-19 Spread in Indonesia
Authors: Syafarina Inna , Wirahman Taufiq , Iryanto Syam Budi , Latifah Arnida Lailatul
Published: January 2023

Three variants of COVID-19 had been found in Indonesia. A control strategy may rely on the transmission rate of the variant. This study aims to investigate how the variants spread in Indonesia by computing a basic and effective reproduction number on the national and province scale. The basic reproduction number shows the indicator of initial transmission rate of alpha variant computed by an exponential growth rate model. The effective reproduction number describes the dynamic of the transmission rate estimated based on a Bayesian approach. This study revealed that each variant shows different characteristics. The alpha variant of COVID-19 in Indonesia was mainly initiated from big cities, then it spread to all provinces quickly because the control strategies were not established well at the beginning. A rapid increase of the effective reproduction number about July 2021 showed a novel delta variant, but it could be managed quite well by a large number of testing and stronger restrictions. Before the end of 2021, a novel variant omicron was also shown by the steeper change of the effective reproduction number. Thus, the variant spread rate can be estimated by how steep the effective reproduction number change is.
Bimodal Keystroke Dynamics-Based Authentication for Mobile Application Using Anagram
Authors: Yunanto Prasti Eko , Barmawi Ari Moesriami
Published: January 2023

Currently, most of the smartphones recognize uses based on static biometrics, such as face and fingerprint. However, those traits were vulnerable against spoofing attack. For overcoming this problem, dynamic biometrics like the keystroke and gaze are introduced since it is more resistant against spoofing attack. This research focuses on keystroke dynamics for strengthening the user recognition system against spoofing attacks. For recognizing a user, the user keystrokes feature used in the login process is compared with keystroke features stored in the keystroke features database. For evaluating the accuracy of the proposed system, words generated based on the Indonesian anagram are used. Furthermore, for conducting the experiment, 34 participants were asked to type a set of words using the smartphone keyboard. Then, each user’s keystroke is recorded. The keystroke dynamic feature consists of latency and digraph which are extracted from the record. According to the experiment result, the error of the proposed method is decreased by 23.075% of EER with FAR and FRR are decreased by 16.381% and 10.41% respectively, compared with Kim’s method. It means that the proposed method is successful increase the biometrics performance by reducing the error rates
O negro na literatura potiguar contemporânea
Authors: Humberlan Arruda De Oliveira Francisco , Angélica Braga do Nascimento Marília , De Souza Farias Ana Clara , Siqueira Cunha Ana Luiza
Published: January 2023

Este artigo é fruto de projeto de pesquisa que visou investigar as imagens do negro na literatura potiguar contemporânea. Como os estudos sobre a produção poética do Rio Grande do Norte são mais voltados para o início do século XX e a modernidade, este artigo analisa, a partir dos fundamentos teóricos, literários e culturais da figura do negro na contemporaneidade, as imagens suscitadas na poesia potiguar dos anos iniciais do século XXI. Este trabalho traz um recorte temporal compreendido entre os anos 2000 e 2021 focalizando três escritores: Alexandre Alves, Drika Duarte e Helena Monteiro. A seleção dos poemas levou em consideração dois critérios: i) a produção poética significativa em volume e/ou recepção crítica e; ii) a autoria e/ou temática do negro. Como aporte teórico, o artigo usa o conceito de Literatura Afrodescendente, de Duarte (2002), o de Literatura Suprarregional, de Arendt (2011), e o de Imagologia, de Ribeiro (2005). A nossa hipótese é a de que a escrita poética, de 2000 a 2020 no Rio Grande do Norte, é sucumbida pela noção de regional como espaço geográfico natural e pela crítica literária. Ainda que políticas identitárias tenham sido fomentadas no recorte temporal em questão, a imagem do negro é minimizada na produção poética potiguar, e a sua representação ocorre por meio de vozes dissonantes, e dispersas, no cenário cultural e literário potiguar.
Só se aprende a fazer, fazendo! desenvolvendo as competências argumentativas dos discentes: o trabalho com o gênero textual artigo de opinião
Authors: De França José Marcos Ernesto Santana , FERREIRA SUELY DE SOUSA MARTINS
Published: January 2023

A argumentação está presente em inúmeras práticas discursivas do cotidiano, tanto por meio da escrita, como também através da oralidade. Nessa direção, o presente artigo tem como objetivo propor o ensino do gênero textual artigo de opinião como ferramenta pedagógica para o desenvolvimento de competências argumentativas dos discentes. Nesse passo, analisa-se a construção da argumentação na produção de artigos de opinião por alunos do 8º ano a partir de uma sequência didática, junto a uma escola pública de ensino fundamental do município de Crato-CE. A metodologia adotada na pesquisa foi de base qualitativa, com foco na modalidade pesquisa-ação, com base nas experiências de regência da pesquisadora durante o Estágio Supervisionado I, do curso de Letras. Para isso, a fundamentação teórica foi ancorada na orientação teórico-metodológica do Interacionismo Sociodiscursivo (ISD), com os autores Schneuwly e Dolz (2004), com foco no gênero textual artigo de opinião, segundo Boff, Köche e Marinello (2009) e Bräkling (2000), e nos aspectos teóricos da argumentação com Perelman e Olbrechts-Tyteca (2014), Fiorin (2015) e Koch e Elias (2016). A análise das produções textuais que constituíram o corpus permitiu observar avanços significativos quanto ao desenvolvimento argumentativo dos discentes entre a produção inicial e a produção final, além de evidenciar que as práticas de ensino voltadas para a argumentação auxiliam na formação do sujeito crítico-reflexivo e que o trabalho com o artigo de opinião se mostra um forte aliado para o desenvolvimento da competência argumentativa dos discentes.
A concordância verbal na fala de coruripenses (Alagoas)
Authors: Sedrins Adeilson , Dos Santos Vieira Pollyanna Vanessa
Published: January 2023

Este artigo apresenta os resultados de um estudo sobre a variação no fenômeno da concordância verbal em dados de fala de moradores do município de Coruripe, localizado no interior do Estado de Alagoas, considerando, principalmente, a atuação da variável escolaridade como elemento condicionante no uso de formas disponíveis. O corpus da pesquisa foi constituído por dados de fala de 36 informantes nascidos e residentes no município e o modelo teórico-metodológico em que o estudo foi desenvolvido foi o da Teoria da Variação e da Mudança Linguística (LABOV, 1972). Os resultados apontam que quanto maior a escolaridade, maior a ocorrência de concordância padrão entre os falantes, no entanto, considerando os percentuais de aplicação da forma padrão, observamos que se distancia daquele encontrado em comunidades bastantes urbanizadas, falantes do português.
Palladium-Catalyzed C-N Coupling in the Synthesis of Benzodiazepines
Authors: Grewal Pooja , Kaur Navjeet
Published: January 2023

This review article is focused on the reactions, which include the syntheses of various classes of benzodiazepines in the presence of a Pd catalyst. The catalyst used here belongs to the transition metal group and nowadays, there is keen interest in numerous methods for the coupling reaction in the presence of a catalyst to prepare the biologically active heterocyclic compounds. In particular, the use of domino reactions as inter- or intramolecular processes is reported as an efficient and eco-compatible tool to obtain differently functionalized benzodiazepines. 2,3-benzodiazepines having pharmaceutical interest are synthesized via asymmetric catalysis. The catalyst used in this synthesis is palladium-chiral bidentate phosphine complex and thiazolium-derived carbine. The 1,3-benzodiazepines are prepared by A3 coupling. In this reaction, the propargylamine was first added to the isocyanates. After that, hydroxylation of alkyne occurs in the presence of a Pd catalyst in a one-pot manner to yield the 1,3-benzodiazepines.
Strategic One-pot Synthesis of Glycosyl Annulated Phosphorylated/ Thiophosphorylated 1,2,3-Triazole Derivatives Using CuFe2O4 Nanoparticles as Heterogeneous Catalyst, their DFT and Molecular Docking Studies as Triazole Fungicides
Authors: Bendi Anjaneyulu , Rao Gullapalli Bhaskara Dharma
Published: January 2023

In the present study, we have introduced an efficient solvent-free protocol for the synthesis of glycosyl annulated phosphorylated/thiophosphorylated 1,2,3-triazole derivatives using reusable CuFe2O4 magnetic nanoparticles as a heterogeneous catalyst with the protocols of popular click chemistry approach. Quantum chemical calculations of all the reactants and products have been calculated using density functional theory with Spartan-18 software. In addition, the molecular docking studies of all the glycosyl annulated phosphorylated/thiophosphorylated 1,2,3- triazole derivatives have been studied as effective fungicides against CaCYP51 (PDB ID 5EQB), protein of P. infestans effector target site (PDB ID: 2NAR), and SsCYP51(PDB code: 6CR2) using Autodock Vina and Discovery Studio software. Among the three different proteins, the binding energies of the compounds (5a-d) with CaCYP51 (PDB ID 5EQB) have shown better results in the range of 7.0 to 7.4 kcal/mol. Hence, these compounds may be used as strong fungicides for the inhibition of CaCYP51 (PDB ID 5EQB). In conclusion, the synthesized compounds may be better useful in agrochemical applications as vital fungicides.
The COVID-19 Pandemic and Psychological Health Problems: Repeated Cross-Sectional Study
Authors: Hysenaj Arben , Dorambari Diedon , Hoxha Agron
Published: January 2023

Introduction:

The COVID-19 pandemic strained many aspects of daily life, and the propensity of the virus to spread rapidly affected the world, bringing both stress and psychological health problems throughout the world. This study aims to investigate the level of psychological issues and problems among the population during the COVID-19 pandemic.

Methodology:

This was a repeated cross-sectional study (N = 650) made of Pre-Pandemic (n = 338) and During-Pandemic COVID-19 (n = 312) samples conducted in Dardania (Kosovo) municipalities of Prishtina, Prizren, Ferizaj, Gjilan, Gjakova, Peja, Podujeva, Suhareka, Mitrovica, and Vushtrri. The study used both the Demographic Questionnaire and the General Health Questionnaire 28.

Results:

There was a significant difference between the two samples in psychological health problems in general (p = .001), as well as depression (p = .001), social dysfunction (p = .001), somatization (p = .001), anxiety and insomnia (p = .001) in particular. Furthermore, Chi-square analysis showed a very large effect size for participants’ reported accidents, natural disasters, losing a loved one, chronic illnesses, displacement, Domestic violence, imprisonment, and especially divorce.

Conclusion:

The COVID-19 pandemic increased psychological health problems, and there is a need for the mobilization of psychological health experts to support and decrease the level of risk in the population in future times.
A Digital Lifestyle Coach (E-Supporter 1.0) to Support People With Type 2 Diabetes: Participatory Development Study
Authors: Hietbrink Eclaire A G , Middelweerd Anouk , van Empelen Pepijn , Preuhs Katharina , Konijnendijk Annemieke A J , Oude Nijeweme-d’Hollosy Wendy , Schrijver Laura K , Laverman Gozewijn D , Vollenbroek-Hutten Miriam M R
Published: January 2023

Background

A healthy lifestyle, including regular physical activity and a healthy diet, is becoming increasingly important in the treatment of chronic diseases. eHealth interventions that incorporate behavior change techniques (BCTs) and dynamic tailoring strategies could effectively support a healthy lifestyle. E-Supporter 1.0 is an eCoach designed to support physical activity and a healthy diet in people with type 2 diabetes (T2D).

Objective

This paper aimed to describe the systematic development of E-Supporter 1.0.

Methods

Our systematic design process consisted of 3 phases. The definition phase included the selection of the target group and formulation of intervention objectives, and the identification of behavioral determinants based on which BCTs were selected to apply in the intervention. In the development phase, intervention content was developed by specifying tailoring variables, intervention options, and decision rules. In the last phase, E-Supporter 1.0 integrated in the Diameter app was evaluated using a usability test in 9 people with T2D to assess intervention usage and acceptability.

Results

The main intervention objectives were to stimulate light to moderate-vigorous physical activities or adherence to the Dutch dietary guidelines in people with T2D. The selection of behavioral determinants was informed by the health action process approach and theories explaining behavior maintenance. BCTs were included to address relevant behavioral determinants (eg, action control, self-efficacy, and coping planning). Development of the intervention resulted in 3 types of intervention options, consisting of motivational messages, behavioral feedback, and tailor-made supportive exercises. On the basis of IF-THEN rules, intervention options could be tailored to, among others, type of behavioral goal and (barriers to) goal achievement. Data on these variables could be collected using app data, activity tracker data, and daily ecological momentary assessments. Usability testing revealed that user experiences were predominantly positive, despite some problems in the fixed delivery of content.

Conclusions

The systematic development approach resulted in a theory-based and dynamically tailored eCoach. Future work should focus on expanding intervention content to other chronic diseases and lifestyle behaviors, enhancing the degree of tailoring and evaluating intervention effects on acceptability, use, and cost-effectiveness.
Training Staff Across the Veterans Affairs Health Care System to Use Mobile Mental Health Apps: A National Quality Improvement Project
Authors: McGee-Vincent Pearl , Mackintosh Margaret-Anne , Jamison Andrea L , Juhasz Katherine , Becket-Davenport Colleen , Bosch Jeane , Avery Timothy J , Glamb Lauren , Hampole Shilpa
Published: January 2023

Background

The National Center for PTSD, within the Department of Veterans Affairs (VA), has developed a suite of free, publicly available, evidence-informed apps that can reach an increasing number of veterans and bridge gaps in care by providing resources to those who are not engaged in mental health treatment. To expand the reach of these apps, staff across VA service lines learned about these apps, their features and limitations, and how to introduce them to veterans.

Objective

This study aimed to develop, disseminate, and evaluate a training for multidisciplinary staff as part of a national quality improvement project to increase the reach of mobile mental health apps as a resource for veterans.

Methods

Sites from all of VA’s 18 geographic regions enrolled in this project. At each site, a minimum of 25 VA staff members who had direct contact with veterans, including staff from the mental health service line and all other service lines, were recruited to participate. Training included a 3-hour multidisciplinary core module, and a 1-hour clinical integration module designed specifically for mental health clinicians. Owing to the COVID-19 pandemic, the trainings were adapted to a live, web-based format. Pre- and posttraining surveys assessed program reach (ie, participants enrolled per site), satisfaction, and effectiveness of the training as measured by changes in knowledge, basic skills, and behavioral intentions to use apps with veterans.

Results

A total of 1110 participants representing 34 disciplines at 19 VA sites completed the training. Overall, 67% (743/1109) of participants were mental health staff members. Sites averaged 58.4 participants (SD 36.49, median [IQR] 51). Most (961/1024, 93.85%) participants were satisfied with the training and reported that they (941/1018, 92.44%) would recommend it to others. App knowledge scores significantly increased from pretraining (mean 80.8% correct, SD 15.77%) to posttraining (mean 91.1% correct, SD 9.57%; P<.001). At posttraining, participants also reported greater confidence in their ability to show veterans how to download (z=−13.86; P<.001) and use VA mental health apps (z=−15.13; P<.001). There was near universal endorsement by staff for their intentions to recommend apps to veterans as well as their ability to think of at least one specific veteran to whom they could recommend an app. Staff also reported a strong motivation to encourage other VA staff to share apps with veterans.

Conclusions

The training far exceeded the initial goals for staff recruitment and training for all three metrics. Overall, 33% (366/1109) of participants came from service lines outside of mental health, indicating the feasibility of introducing these mental health resources during medical appointments and in other contexts.
REDCap as a platform for cutaneous disease management in Street Medicine outreach: A cross-sectional study (Preprint)
Authors: Eachus Emily , Rasul Taha , Schwartz Kayla , Keri Jonette , Mathew Megan , Bergholz Daniel
Published: January 2023

BACKGROUND

People experiencing unsheltered homelessness (PEUH) are a vulnerable patient cohort who suffer from high levels of disease morbidity and mortality [1]. Because this population experiences complicated and frequent barriers to care, these patients are often unable to receive timely and specialized care. Research Electronic Data Capture (REDCap) is a modular web application that can be used to create databases for clinical research and projects [4].

OBJECTIVE

This cross-sectional study evaluates the use of a custom, REDCap-based electronic medical record in cutaneous disease management for a Miami-based Street Medicine organization.

METHODS

Between July 2021 - January 2022, REDCap records were retrieved pertaining to skin or nail-based problems among PEUH. In cases that required further elaboration, additional fields were added into patient charts such as wound care (Figure 2a).

RESULTS

Among 140 unique patients seen in a street setting, 112 diagnoses were recorded. The sample evaluated included 68.1% males and 31.9% females. The patient cohort was diverse, with 50.2% black, 45.8% white, and the remainder asian or native american. The highest morbidity lesions in terms of disability and risk for infection encountered were chronic wounds and ulcers, many of which required multiple care instances.

CONCLUSIONS

The use of a free, customizable REDCap system was instrumental in recording cutaneous diseases among PEUH, both for treatment and follow-up purposes. REDCap can be a promising tool for charitable organizations with limited funding by virtue of its cost-effective and accessible management of sensitive patient data. REDCap-based electronic medical records appear to be valuable adjuncts to established Street Medicine teams, particularly for the use of specialized services like dermatology. These can be modified for special circumstances and patient populations, thereby improving the delivery of care to people experiencing unsheltered homelessness in a cost-effective manner.
Acceptance of Telemedicine Compared to In-Person Consultation From the Providers' and Users’ Perspectives: Multicenter, Cross-Sectional Study in Dermatology (Preprint)
Authors: Maul Lara Valeska , Jahn Anna Sophie , Pamplona Gustavo S P , Streit Markus , Gantenbein Lorena , Müller Simon , Nielsen Mia-Louise , Greis Christian , Navarini Alexander A , Maul Julia-Tatjana
Published: January 2023

BACKGROUND

Teledermatology is currently finding its place in modern health care worldwide as a rapidly evolving field.

OBJECTIVE

The aim of this study was to investigate the acceptance of teledermatology compared to in-person consultation from the perspective of patients and professionals.

METHODS

This multicenter, cross-sectional pilot study was performed at secondary and tertiary referral centers of dermatology in Switzerland from August 2019 to January 2020. A customized questionnaire addressing demographics and educational data, experience with telemedicine, and presumed willingness to replace in-patient consultations with teledermatology was completed by dermatological patients, dermatologists, and health care workers in dermatology.

RESULTS

Among a total of 664 participants, the ones with previous telemedicine experience (171/664, 25.8%) indicated a high level of overall experience with it (patients: 73/106, 68.9%, dermatologists: 6/8, 75.0%, and health care workers: 27/34, 79.4%). Patients, dermatologists, and health care workers were most likely willing to replace in-person consultations with teledermatology for minor health issues (353/512, 68.9%; 37/45, 82.2%; and 89/107, 83.2%, respectively). We observed a higher preference for telemedicine among individuals who have already used telemedicine (patients: P<.001, dermatologists: P=.03, and health care workers, P=.005), as well as among patients with higher educational levels (P=.003).

CONCLUSIONS

This study indicates that the preference for teledermatology has a high potential to increase over time since previous experience with telemedicine and a higher level of education were associated with a higher willingness to replace in-patient consultations with telemedicine. We assume that minor skin problems are the most promising issue in teledermatology. Our findings emphasize the need for dermatologists to be actively involved in the transition to teledermatology.

CLINICALTRIAL

ClinicalTrials.gov NCT04495036; https://classic.clinicaltrials.gov/ct2/show/NCT04495036
The Impact of COVID-19 and Exposure to Violent Media Content on Cyber Violence Victimization Among Adolescents in South Korea: National Population-Based Study (Preprint)
Authors: Lee Eugene , Schulz Peter J , Lee Hye Eun
Published: January 2023

BACKGROUND

Because of the COVID-19 pandemic and consequent stay-at-home mandates, adolescents faced isolation and a decline in mental health. With increased online activity during this period, concerns arose regarding exposure to violent media content and cyber victimization among adolescents. Yet, the precise influence of pandemic-related measures on experiences of cyber violence remains unclear. Hence, it is pertinent to investigate whether the pandemic altered the dynamics of cyber violence victimization for individuals.

OBJECTIVE

This study aims to investigate the effects of COVID-19 and exposure to violent media content on cyber violence victimization among adolescents in South Korea.

METHODS

We used national survey data from 2019 (n=4779) and 2020 (n=4958) to investigate the potential impact of COVID-19 on the prevalence of cyber violence among young adolescents. The data encompassed responses from elementary fourth-grade students to senior high school students, probing their exposure to violent media content, average internet use, as well as experiences of victimization and perpetration.

RESULTS

The analysis revealed a noteworthy decline in cyber victimization during 2020 compared with 2019 (B=–0.12, t=–3.45, P<.001). Furthermore, being a perpetrator significantly contributed to cyber victimization (B=0.57, t=48.36, P<.001). Additionally, younger adolescents (β=–.06, t=–6.09, P<.001), those spending more time online (β=.18, t=13.83, P<.001), and those exposed to violent media (β=.14, t=13.89, P<.001) were found to be more susceptible to victimization.

CONCLUSIONS

Despite the widespread belief that cyber violence among adolescents surged during COVID-19 due to increased online activity, the study findings counter this assumption. Surprisingly, COVID-19 did not exacerbate cyber victimization; rather, it decreased it. Given the strong correlation between cyber victimization and offline victimization, our attention should be directed toward implementing real-life interventions aimed at curbing violence originating from in-person violence at school.