bluuebunny/crossref_metadata_2025 huggingface dataset:
LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1
Authors: Shen Qiming , Sun Yanbin , Xu Shun
Published: September 2020

Background

Non-small cell lung cancer (NSCLC) is one of the major types of lung cancer, which is a prevalent human disease all over the world. LncRNA LINC01503 is a super-enhancer-driven long non-coding RNA that is dysregulated in several types of human cancer. However, its role in NSCLC remains unknown.

Methods

Thirty NSCLC patients were recruited between April 2012 and April 2016. Luciferase reporter assay, qRT-PCR, Cell Counting Kit-8 (CCK-8), Transwell migration assay, RNA pull-down assay, western blotting, 5-ethynyl-29-deoxyuridine (EdU) assays, and flow cytometry were utilized to characterize the roles and relationships among LINC01503, miR-342-3p, and LASP1 in NSCLC. The transplanted mouse model was built to examine their biological functions in vivo.

Results

We demonstrated that the expression of lncRNA LINC01503 and LIM and SH3 domain protein 1 (LASP1) were upregulated and miR-342-3p was downregulated in NSCLC samples and cell lines. Functional experiments revealed that inhibiting the expression of LINC01503 or over-expression of miR-342-3p inhibited NSCLC growth and metastasis both in vitro and in vivo. In addition, LINC01503 could bind to miR-342-3p and affect the expression of LASP1.

Conclusion

These results provide a comprehensive analysis of the roles of LINC01503 as a competing endogenous RNA (ceRNA) in NSCLC progression.
Association between changes in economic activity and catastrophic health expenditure: findings from the Korea Health Panel Survey, 2014–2016
Authors: Lee Hyeon Ji , Lee Doo Woong , Choi Dong-Woo , Oh Sarah Soyeon , Kwon Junhyun , Park Eun-Cheol
Published: September 2020

Background

The rate of catastrophic health expenditure (CHE) continues to rise in South Korea. This study examined the association between changes in economic activity and CHE experiences in South Korea.

Methods

This study analyzed the Korea Health Panel Survey data using a logistic regression analysis to study the association between changes in economic activity in 2014–2015 and the participants’ CHE experiences in 2015. The study included a total of 12,454 individuals over the age of 19. The subgroup analyses were organized by sex, age, health-related variables, and household level variables, and the reasons for leaving economic activity.

Results

Those who quit economic activities were more likely to experience CHE than those who continued to engage in economic activities (OR [odds ratio] = 2.10; 95% CI [confidence interval]: 1.31–3.36). The subgroup analysis results, according to health-related variables, showed that there is a tendency to a higher Charlson comorbidity index, a higher OR, and, in groups that quit their economic activities, people with disabilities were more likely to experience CHE than people without disabilities (OR = 5.63; 95% CI 1.71–18.59, OR = 1.82; 95% CI 1.08–3.08, respectively). Another subgroup analysis found that if the reason for not participating in economic activity was a health-related issue, the participant was more likely to experience CHE (active → inactive: OR = 2.40; 95% CI 0.61–9.43, inactive → inactive OR = 1.65; 95% CI 1.01–2.68).

Conclusions

Those individuals who became unemployed were more likely to experience CHE, especially if health problems precipitated the job loss. Therefore, efforts are needed to expand coverage for those people who suffer from high medical expenses.
Repair of distal thumb degloving injury using combination of reverse dorsoradial flap of the thumb and middle finger proper digital arterial island flap
Authors: Hao Ruizheng , Wang Bin , Wang Hui , Yang Huanyou , Huo Yongxin
Published: September 2020

Background

To examine the efficacy of combination of the reverse dorsoradial flap of the thumb and middle finger proper digital arterial island flap for repair of distal thumb degloving injury.

Methods

Twelve patients with mechanical distal thumb degloving injuries were treated between February 2017 and August 2019. A combination of the reverse dorsoradial flap of the thumb and the middle finger proper digital arterial island flap were used. Semmes–Weinstein (SW) monofilament and static two-point discrimination (S-2PD) tests, active range-of-motion (ROM) of the joints, cold intolerance, visual analog scale (VAS) score patient complications, and patient satisfaction were sequentially evaluated.

Results

Two cases with postoperative flap blisters were treated at time of dressing changes up to successful scab formation. One case with postoperative arterial crisis of finger arterial dorsal branch vessel was successfully released in the pedicle. Ten cases healed by first intention and 2 cases by secondary intention. Twelve patients received follow-up examinations between 3 and 20 months (average 13 months) post-treatment, and all exhibited full, soft flaps with no fingertip pain.

Conclusion

The combined use of the reverse dorsoradial flap of the thumb and the middle finger proper digital arterial island flap is a practical and effective approach to surgical repair of distal thumb degloving injuries.
Spectrum of microarchitectural bone disease in inborn errors of metabolism: a cross-sectional, observational study
Authors: Sidhu Karamjot , Ali Bilal , Burt Lauren A. , Boyd Steven K. , Khan Aneal
Published: September 2020

Background

Patients diagnosed with inborn errors of metabolism (IBEM) often present with compromised bone health leading to low bone density, bone pain, fractures, and short stature. Dual-energy X-ray absorptiometry (DXA) is the current gold standard for clinical assessment of bone in the general population and has been adopted for monitoring bone density in IBEM patients. However, IBEM patients are at greater risk for scoliosis, short stature and often have orthopedic hardware at standard DXA scan sites, limiting its use in these patients. Furthermore, DXA is limited to measuring areal bone mineral density (BMD), and does not provide information on microarchitecture.

Methods

In this study, microarchitecture was investigated in IBEM patients (n = 101) using a new three-dimensional imaging technology high-resolution peripheral quantitative computed tomography (HR-pQCT) which scans at the distal radius and distal tibia. Volumetric BMD and bone microarchitecture were computed and compared amongst the different IBEMs. For IBEM patients over 16 years-old (n = 67), HR-pQCT reference data was available and Z-scores were calculated.

Results

Cortical bone density was significantly lower in IBEMs associated with decreased bone mass when compared to lysosomal storage disorders (LSD) with no primary skeletal pathology at both the radius and tibia. Cortical thickness was also significantly lower in these disorders when compared to LSD with no primary skeletal pathology at the radius. Cortical porosity was significantly greater in hypophosphatasia when compared to all other IBEM subtypes.

Conclusion

We demonstrated compromised bone microarchitecture in IBEMs where there is primary involvement of the skeleton, as well as IBEMs where skeletal complications are a secondary outcome. In conclusion, our findings suggest HR-pQCT may serve as a valuable tool to monitor skeletal disease in the IBEM population, and provides insight to the greatly varying bone phenotype for this cohort that can be used for clinical monitoring and the assessment of response to therapeutic interventions.
Genome resequencing data for Iranian local dogs and wolves
Authors: Amiri Ghanatsaman Zeinab , Wang Guo-Dong , Asadi Fozi Masood , Zhang Ya-Ping , Esmailizadeh Ali
Published: September 2020

Objective

The data provided herein represent the whole-genome resequencing data related to three wolves and three Iranian local dogs. The understanding of genome evolution during animal domestication is an interesting subject in genome biology. Dog is an excellent model for understanding of domestication due to its considerable variety of behavioral and physical traits. The Zagros area of current day Iran has been identified as one of the initial centers of animal domestication. The availability of the complete genome sequences of Iranian local canids can be a valuable resource for researchers to address questions and testing hypotheses on the dog domestication process.

Data description

We collected blood samples from six Iranian local canids including two hunting dogs (Saluki breed), a mastiff dog (Qahderijani ecotype) and three wolves. We extracted genomic DNA from blood samples. Sequence data were produced using the Illumina HiSeq 2500 system. All sequence data are available in the National Genomics Data Center (NGDC), Genome Sequence Archive (GSA) database under the accession of CRA001324 and the National Center for Biotechnology Information (NCBI) under the accession of PRJNA639312. The short-read sequences with the mean depth of 16X were aligned to the dog reference genome (CanFam3.1) and achieved 99% coverage of the reference assembly. The obtained information from this experiment will be useful in evolutionary biology.
Reducing Glut2 throughout the body does not result in cognitive behaviour differences in aged male mice
Authors: Morrice Nicola , van Aalten Lidy , McNeilly Alison , McCrimmon Rory J. , Pearson Ewan R. , Langston Rosamund , Sutherland Calum
Published: September 2020

Objectives

GLUT2 is a major facilitative glucose transporter, expressed from the SLC2A2 gene, with essential roles in the liver. Recent work in mice has shown that preventing Glut2 production in specific neuronal populations increases sugar-seeking behaviour, highlighting the importance of Slc2a2 gene expression in the brain. It implies that reduced GLUT2 in the brain, due to genetic polymorphisms or disease, impacts health through behaviour change. Defects in glucose transport in the brain are observed in conditions including type-2 diabetes and dementia. Few studies have directly examined the effect of modulating neuronal glucose transporter expression on cognitive function. The aim of this study was to investigate whether inactivating one Slc2a2 allele throughout the body had major effects on cognition. Cognitive tests to assess recognition memory, spatial working memory and anxiety were performed in Slc2a2 whole-body heterozygous mice (i.e. reduced Glut2 mRNA and protein), alongside littermates expressing normal levels of the transporter.

Results

No significant effects on neurological functions and cognitive capabilities were observed in mice lacking one Slc2a2 allele when fed a chow diet. This suggests that the minor variations in GLUT2 levels that occur in the human population are unlikely to influence behaviour and basic cognition.
Alterations in gene expression in the spinal cord of mice lacking Nfix
Authors: Matuzelski Elise , Essebier Alexandra , Harris Lachlan , Gronostajski Richard M. , Harvey Tracey J. , Piper Michael
Published: September 2020

Objective

Nuclear Factor One X (NFIX) is a transcription factor expressed by neural stem cells within the developing mouse brain and spinal cord. In order to characterise the pathways by which NFIX may regulate neural stem cell biology within the developing mouse spinal cord, we performed an microarray-based transcriptomic analysis of the spinal cord of embryonic day (E)14.5 Nfix−/− mice in comparison to wild-type controls.

Data description

Using microarray and differential gene expression analyses, we were able to identify differentially expressed genes in the spinal cords of E14.5 Nfix−/− mice compared to wild-type controls. We performed microarray-based sequencing on spinal cords from n = 3 E14.5 Nfix−/− mice and n = 3 E14.5 Nfix+/+ mice. Differential gene expression analysis, using a false discovery rate (FDR) p-value of p < 0.05, and a fold change cut-off for differential expression of >  ± 1.5, revealed 1351 differentially regulated genes in the spinal cord of Nfix−/− mice. Of these, 828 were upregulated, and 523 were downregulated. This resource provides a tool to interrogate the role of this transcription factor in spinal cord development.
Microbial dark matter filling the niche in hypersaline microbial mats
Authors: Wong Hon Lun , MacLeod Fraser I. , White Richard Allen , Visscher Pieter T. , Burns Brendan P.
Published: September 2020

Background

Shark Bay, Australia, harbours one of the most extensive and diverse systems of living microbial mats that are proposed to be analogs of some of the earliest ecosystems on Earth. These ecosystems have been shown to possess a substantial abundance of uncultivable microorganisms. These enigmatic microbes, jointly coined as ‘microbial dark matter’ (MDM), are hypothesised to play key roles in modern microbial mats.

Results

We reconstructed 115 metagenome-assembled genomes (MAGs) affiliated to MDM, spanning 42 phyla. This study reports for the first time novel microorganisms (Zixibacterial order GN15) putatively taking part in dissimilatory sulfate reduction in surface hypersaline settings, as well as novel eukaryote signature proteins in the Asgard archaea. Despite possessing reduced-size genomes, the MDM MAGs are capable of fermenting and degrading organic carbon, suggesting a role in recycling organic carbon. Several forms of RuBisCo were identified, allowing putative CO2 incorporation into nucleotide salvaging pathways, which may act as an alternative carbon and phosphorus source. High capacity of hydrogen production was found among Shark Bay MDM. Putative schizorhodopsins were also identified in Parcubacteria, Asgard archaea, DPANN archaea, and Bathyarchaeota, allowing these members to potentially capture light energy. Diversity-generating retroelements were prominent in DPANN archaea that likely facilitate the adaptation to a dynamic, host-dependent lifestyle.

Conclusions

This is the first study to reconstruct and describe in detail metagenome-assembled genomes (MAGs) affiliated with microbial dark matter in hypersaline microbial mats. Our data suggests that these microbial groups are major players in these systems. In light of our findings, we propose H2, ribose and CO/CO2 as the main energy currencies of the MDM community in these mat systems.
Deep learning-based question answering system for intelligent humanoid robot
Authors: Budiharto Widodo , Andreas Vincent , Gunawan Alexander Agung Santoso
Published: September 2020

Background

The development of Intelligent Humanoid Robot focuses on question answering systems that can interact with people is very limited. In this research, we would like to propose an Intelligent Humanoid Robot with the self-learning capability for accepting and giving responses from people based on Deep Learning and Big Data knowledge base. This kind of robot can be used widely in hotels, universities, and public services. The Humanoid Robot should consider the style of questions and conclude the answer through conversation between robot and user. In our scenario, the robot will detect the user’s face and accept commands from the user to do an action.

Findings

The question from the user will be processed using deep learning, and the result will be compared to the knowledge base on the system. We proposed our Deep Learning approach, based on Recurrent Neural Network (RNN) encoder, Convolution Neural Network (CNN) encoder, with Bidirectional Attention Flow (BiDAF).

Conclusions

Our evaluation indicates that using RNN based encoder with BiDAF gives a higher score, than CNN encoder with the BiDAF. Based on our experiment, our model get 82.43% F1 score and the RNN based encoder will give a higher EM/F1 score than using the CNN encoder.
The relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanically ventilated patients
Authors: Levin Gabrielle , Boyd J. Gordon , Day Andrew , Hunt Miranda , Maslove David M. , Norman Patrick , O’Callaghan Nicole , Sibley Stephanie , Muscedere John
Published: September 2020

Introduction

Immunological dysfunction is common in critically ill patients but its clinical significance and the optimal method to measure it are unknown. The level of tumor necrosis factor alpha (TNF-α) after ex-vivo whole blood stimulation with lipopolysaccharide (LPS) has been proposed as a possible method to quantify immunological function. We hypothesized that in a cohort of critically ill patients, those with a lower post-stimulation TNF-α level would have increased rates of nosocomial infections (NIs) and worse clinical outcomes.

Methods

A secondary analysis of a phase 2 randomized, multi-centre, double-blinded placebo-controlled trial. As there was no difference between treatment and control arms in outcomes and NI rate, all the patients were analyzed as one cohort. On enrolment, day 4, 7, and weekly until day 28, whole blood was incubated with LPS ex-vivo and subsequent TNF-α level was measured. Patients were grouped in tertiles according to delta and peak TNF-α level. The primary outcome was the association between NIs and tertiles of TNF-α level post LPS stimulation; secondary outcomes included ICU and 90-day mortality, and ICU and hospital length of stay.

Results

Data was available for 201 patients. Neither the post LPS stimulation delta TNF-α group nor the peak TNF-α post-stimulation group were associated with the development of NIs or clinical outcomes. Patients in the highest tertile for post LPS stimulation delta TNF-α compared to the lowest tertile were younger [61.1 years ± 15.7 vs. 68.6 years ± 12.8 standard deviations (SD) in the lowest tertile], had lower acuity of illness (APACHE II 25.0 ± 9.7 vs. 26.7 ± 6.1) and had lower baseline TNF-α (9.9 pg/mL ± 19.0 vs. 31.0 pg/mL ± 68.5). When grouped according to peak post-stimulation TNF-α levels, patients in the highest tertile had higher serum TNF-α at baseline (21.3 pg/mL ± 66.7 compared to 6.5 pg/mL ± 9.0 in the lowest tertile).

Conclusion

In this prospective multicenter study, ex-vivo stimulated TNF-α level was not associated with the occurrence of NIs or clinical outcomes. Further study is required to better ascertain whether TNF levels and ex-vivo stimulation can be used to characterize immune function in critical illness and if other assays might be better suited to this task.
The roles of miRNA, lncRNA and circRNA in the development of osteoporosis
Authors: Yang Yang , Yujiao Wang , Fang Wang , Linhui Yuan , Ziqi Guo , Zhichen Wei , Zirui Wang , Shengwang Wang
Published: September 2020

Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of life of patients. However, epigenetic mechanisms involved in the development of osteoporosis remain unclear. There is accumulating evidence that epigenetic modifications may represent mechanisms underlying the links of genetic and environmental factors with increased risk of osteoporosis and bone fracture. Some RNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been shown to be epigenetic regulators with significant involvement in the control of gene expression, affecting multiple biological processes, including bone metabolism. This review summarizes the results of recent studies on the mechanisms of miRNA-, lncRNA-, and circRNA-mediated osteoporosis associated with osteoblasts and osteoclasts. Deeper insights into the roles of these three classes of RNA in osteoporosis could provide unique opportunities for developing novel diagnostic and therapeutic approaches to this disease.
Roles of fibrinolytic factors in the alterations in bone marrow hematopoietic stem/progenitor cells during bone repair
Authors: Okada Kiyotaka , Nishioka Minoru , Kaji Hiroshi
Published: September 2020

In bone tissues, metabolic turnover through bone resorption by osteoclasts and bone formation by osteoblasts, termed bone remodeling, is strictly controlled and maintains homeostasis. Fibrinolytic factors are expressed in osteoclasts and osteoblasts, and are involved in bone remodeling through bone resorption and formation. The repair/regeneration process after bone injury is divided into the acute inflammatory, repair, and remodeling stages. Osteoblasts, osteoclasts, chondrocytes, and macrophages involved in the bone repair process originate from hematopoietic stem/progenitor cells (HSPCs) and mesenchymal stem cells (MSCs) in the bone marrow. Therefore, stem cells in the bone marrow may be strongly influenced by bone injury. The urokinase-type PA (u-PA)/plasminogen (Plg) system functions in macrophage accumulation/phagocytosis through chemokines in the acute inflammatory stage, and Plg increases blood vessel-related growth factor expression, being involved in vascularization in mice. Plasminogen activator inhivitor-1 (PAI-1) causes bone loss and delayed bone repair through the inhibition of osteoblast differentiation in a drug-induced diabetes model in mice. Plg is considered to induce transforming growth factor-β (TGF-β) production in macrophages in the bone repair process, TGF-β release from the extracellular matrix through the activation of matrix metalloproteinase-9 (MMP-9), and stromal cell-derived factor-1 (SDF-1) expression in endosteal preosteoblasts, leading to the induction of bone marrow HSPCs in mice. Based on the above, establishment of a fibrinolytic factor-targeting method efficiently promoting bone repair/regeneration and fracture healing, and development of a new osteoporosis treatment method and diagnostic marker are awaited.
Placard in Hand: A Simple, Inexpensive Intervention to Improve On-Treatment Visit Compliance in a Safety Net Radiation Oncology Patient Population
Authors: Moeller Alexander R. , Clancy Pauline E. , Qureshi Muhammad Mustafa , Guill Jacklyn R. , Dyer Michael A. , Hirsch Ariel E. , Truong Minh-Tam , Mak Kimberley S.
Published: September 2020

PURPOSE:

On-treatment visits (OTVs) for patients undergoing radiotherapy (RT) should occur every five fractions. Compliance with OTVs was identified as a potential issue in a safety-net patient population. This study determined if brightly colored placards given to patients improved OTV compliance.

MATERIALS AND METHODS:

A retrospective analysis of all patients with lung cancer receiving RT from October 1, 2015 to September 30, 2017 evaluated OTV compliance before (No Placard) and after (Placard) the placard was introduced in the clinic. Analysis of variance, χ2 tests, and Fisher’s exact tests were performed to assess differences in continuous and categorical patient and treatment variables, respectively.

RESULTS:

The No Placard group included 48 patients who were scheduled for 151 OTVs. The Placard group included 50 patients who were scheduled for 187 OTVs. The percentage of missed OTVs in the No Placard group was 9.3% (14/151), versus 2.1% (4/187) in the Placard group ( P = .004). Patients in the No Placard group were more likely to speak English (97.9% v 86.0%; P = .060), were less likely to have stage I-III disease (75% v 88%; P = .097), and received lower mean RT doses (48.2 Gy v 55.6 Gy; P = .007). On multivariate analysis adjusting for language, stage, and RT dose, the adjusted mean rate of missed OTVs in the No Placard group was 7.1%, versus 1.4% in the Placard group ( P = .019).

CONCLUSION:

A significant increase in compliance of OTVs was observed with the introduction of brightly colored placards. This represents a simple, inexpensive method to improve OTV compliance in a safety-net setting and may be applicable to other patient populations.
Mental health status and quality of life among Cambodian migrant workers in Thailand
Authors: Chamroen Pall , Samphors Sim , Rachutorn Thiwakorn , S. Dewey Rebecca , Pisey Vong
Published: September 2020

Background:  Migrant workers have become a major issue for Thailand. Most of the migrants are from Myanmar, Cambodia, and Laos. Most are employed in jobs referred to as the “3 Ds”; difficult, dangerous and dirty. However, little is known concerning the living and working conditions, or health-related quality of life of these migrant workers. This study aims to determine factors influencing the quality of life of Cambodian migrant workers in Thailand.

Methods: A cross-sectional study was conducted among 1,211 Cambodian migrant workers in Thailand, using multistage random sampling from eight districts of the two provinces (Sa Kaeo and Surin) with a structured questionnaire interview. The WHOQOL-BREF was used to measure Quality of Life (QOL) with Cronbach’s alpha of 0.77. Mental health status was assessed using the Perceived Stress Scale (PSS) and Center for Epidemiological Studies-Depression (CES-D) scale with Cronbach’s alpha of 0.83. Descriptive statistics provide participant characteristics. Multilevel logistic regression (MLR) were used to determine which factors significantly impacted the outcome measures in terms of the adjusted odds ratio (AOR). P<0.05 was considered statistically significant.

Results: About one third of these migrant workers had a poor quality of life (34.52%; 95%CI: 31.84-37.20), and had moderate-to-high levels of stress (67.96%; 95%CI: 65.33-70.59), and symptoms of depression (69.69%; 95%CI: 67.10-72.29). After controlling other covariate factors, the factors associated with poor QOL were a high level perceived of stress (AOR=3.64; 95%CI: 2.41-5.49; p<0.001); living with family and relatives (AOR=3.63; 95%CI: CI 2.42-5.45; p<0.001); and housing being provided by their employer (AOR=2.66; 95%CI: 1.74-4.08; p<0.001).

Conclusion: Stress was strongly associated with QOL. The living environment was found to be the next most influential factor on QOL. Mental health programs aimed at helping migrant workers to cope with stress and to improve their living conditions will help improve QOL in the target group.
Case Report: Spontaneous perforation of a bicornuate uterus with concomitant sarcoma
Authors: Yim Soobin , Yeo Inji , Lee Myunghwa , Kyeong Kyu-Sang , Cho Hye-yon , Kang Jung Bae , Kyung Min Sun
Published: September 2020

A 47-year-old nulliparous, virginal woman presented to the emergency department with acute abdominal pain. Emergency pelvic ultrasonography and abdominal CT were taken, which showed a significant amount of hemoperitoneum and a bicornuate uterus with about 18cm x 10cm mass on the left uterus. Since the mass had increased vascularity and irregular margins, we thought that the mass could be a uterine sarcoma. Pelvic MRI and PET/CT were taken additionally for oncologic evaluation before surgery. Intraoperative findings showed a ruptured bicornuate uterus with a large mass within the left uterine horn. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Pathologic analysis confirmed an undifferentiated uterine sarcoma. Therefore, we report a case of spontaneous rupture of bicornuate uterus with concomitant sarcoma occurred in a 47-year-old woman.
Development of Types of Culture of Thinking in a Trimodal Organization in the Context of Business Transformation
Authors: Fedorenko A. , Lysenko E.
Published: September 2020

Business transformation requires changes in management business models and types of thinking culture. Human resources play a special role in these processes. The article analyzes the transition of PAO Sberbank, Russia's leading financial institution, to a trimodal organization and the corresponding types of thinking culture - run, change and disrupt. The study of the compliance of the personnel development system with the specifics of a tri-modal organization, conducted using the author's structured interview, showed their imbalance. The authors offer recommendations for the development of the types of culture of thinking change and disrupt, which are most conducive to effective business transformation in accordance with the organization's strategy. The novelty of the study is the first attempt to explore the types of culture of thinking three-modal organization, the practical importance - to develop a specific program for their development.
Diagnostics of the Professional Applicability of Public Administration Staff
Authors: Ershova L. , Selivonenko O.
Published: September 2020

The issue of the effectiveness of public administration is particularly acute in times of crisis and requires, first of all, special attention to the process of holding office by candidates, to assess their professional suitability. The article defines the difficulties of diagnosing the professional fitness of a public civil servant, identifies the need for its assessment as a three-pronged process of measurement, forecasting and formation. The analysis of domestic and foreign experience in assessing the professional aptitude of a public administration specialist shows the similarity of assessment systems and the application of the principle of competitive selection of personnel. The article emphasizes the need to introduce competence-oriented tasks into the assessment procedure that allow determining the zone of development of professional fitness of a civil servant.
Natural Gas Energy Consumption Strategy by Iron and Steel Industry Enterprises
Authors: Koksharov V. , Kirshina I.
Published: September 2020

The existing modern conceptual approaches to the formation of an assessment of the natural gas consumption strategy in the steel industry do not allow assessing comprehensively all the processes that occur in the enterprise affecting the efficiency of natural gas consumption. Due to the fact that natural gas acts an important role as a universal energy resource, both in the economy and in international politics, the modern strategy for assessing the consumption of natural gas in the steel industry is becoming a key factor in increasing competitiveness and guaranteeing sustainable economic growth of the country's steel industry.

The article proposes a conceptual approach to the development of the model in order to assess the strategy of natural gas consumption at iron and steel enterprises, which allows timely management decisions to be taken to increase the organization of efficient energy consumption at the enterprise.

Based on the proposed conceptual approach to assessing the strategy of natural gas consumption at the iron and steel industry, it can be stated that this assessment is interconnected with the assessment of the integral criterion for the implementation of the goals of organizing effective energy management.
Digitalization of the Economy: Problems and Prospects
Authors: Garnov Andrey , Bykova O. , Perepelica D.
Published: September 2020

The article presents the positive and negative externalities of the formation of the digital economy of Russia. The reasons for these problems
Przydrożne sacrum w pamięci lokalnej
Authors: Cichoń Stanisław Szczepan
Published: September 2020

A Roadside Sacrum in Local Memory. Study of the Myślenice Land

The article analyses selected examples of roadside shrines typical for the area of the Myślenice land, Poland. The author points at the characteristic elements of small architecture that reflects spiritual values cultivated by past generations living in the region. The current population scattered across the Myślenice land cultivates with care the individual and collective memory of their ancestors embraced in well-shaped stone blocks of the shrines.
The Air War vs. the Ground Game: An Analysis of Multichannel Marketing in U.S. Presidential Elections
Authors: Zhang Lingling , Chung Doug J.
Published: September 2020

This study jointly examines the heterogeneous effects of television advertising and field operations in U.S. presidential elections.
Evolution of the Greater Manchester Nutrition and Hydration Programme
Authors: Farrer Kirstine , Rose Emma , Haynes Dave , Edwards Steven , McLaughlin John
Published: September 2020

Older adults in the community are at risk of malnutrition and dehydration. The present article aims to outline an intervention and a population-health approach to raise awareness of the importance of good nutrition and hydration in later life. This was addressed by developing strong partnership working, governance frameworks and local steering committees. Through the Greater Manchester Nutrition and Hydration Programme, 39 500 older people have been asked about appetite and weight loss and/or used the PaperWeight Armband to date. A total of 5586 people from this population were found to be at risk of malnutrition. All were provided resources, advice and signposting to address this issue. The gross fiscal return on investment over a 5-year period was 3.2-fold and the net present budget impact was £800 000. The long-term cashable fiscal return on investment was estimated at 2.69. This very promising approach has potential to enable older adults to extend their healthy life span and deliver cost savings to the health and care system.
Supply and demand: Preparing for the next pandemic
Authors: Tkachenko Vladimir
Published: September 2020

To ensure we are ready for another global outbreak, the pharmaceutical industry must take time to reflect on its previous actions, learn from past mistakes and ensure it can respond quickly and definitively to the next crisis
Can patients ask to amend their medical records?
Authors: Molodynski Jayne
Published: September 2020

Dr Jayne Molodynski, medicolegal consultant at Medical Protection, provides advice and guidance on whether patients can request amendments to their medical records
La lectura entre els infants i els joves a catalunya (2018-2019)
Authors: Centelles Jaume
Published: September 2020

En aquest capítol es fa palès un cert estancament del grau d’assoliment de les competències lectores per part dels infants i joves, i es reflexiona sobre algunes de les possibles causes d’aquesta inèrcia conformista que ens porta a un «anar fent» que ens impedeix aprofitar el potencial humà del país. També es relacionen alguns plans institucionals de suport a la lectura, la consolidació d’activitats reeixides —jornades, congressos, grups de treball— que mostren interès de fer de la lectura una pedra angular de l’educació i s’apunten algunes idees o situacions que ens allunyen de l’optimisme que hauria de motivar-nos, si és que ens volem constituir definitivament com a societat lectora.
Roundtable discussion: Thinking together from within the times that worry us.
Authors: Cielemęcka Olga , Rogowska-Stangret Monika , Bhambra Gurminder K. , Pető Andrea , Loyer Jessie , Ivancheva Mariya , Hlín Halldórsdóttir Nanna
Published: September 2020

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Mapping of sexist violence in Valencia (Spain)
Authors: Alonso Sanz Amparo
Published: September 2020

This article examines the ways in which issues of women’s safety in public spacesmight be integrated into artistic practices in art education from an intersectional and queer review of gender in the city. It considers the contributions from human geography, feminism and affect theory, trying to incorporate all of those perspectives into a pedagogical proposal. The first part of the article introduces the main issues to be explored, acknowledging them in the context of recent public debates in Spain that were related to gender and urban safety. The second part presents the results of a participatory, ephemeral, vindictive and artistic action developed with students of amaster’s degree in Secondary Education Teaching in the specialty of visual arts at theUniversity of Valencia: An action of mapping the sexist violence in Valencia. Lastly, the article concludes with the presentation of emotional and educational profits gained by used practices.
Affects, activisms and resistances facing the impacts of Capitaloceno: an embodied learning experience in Chile
Authors: Aedo María Paz , Cabaña Gabriela
Published: September 2020

The planetary transformations of Capitalocene affect us in multiple and heterogeneous forms. In this context, activisms emerging as embodied, experiential and situated manifestations of affectation. This article is an exploration of the activisms and resistances against impacts that Capitalocene -specifically, the extractivism- has had in Chilean society, from the perspective and experience of our own trajectories as global south academics and activists, committed to the entanglements that emerge constantly in the face of the impacts. Our work refers to the affects and resistances that we as authors have had the chance to experience in spaces of training and companionship of activists who resist in territories affected by the mining, agro-export and energy industry; and those who studied the Diploma in Social Ecology and Political Ecology from the Group of Agroecology and the Environment at the University of Santiago, offered between 2013 and 2017. Based on these experiences, we argue that the "affective turn" offers an indispensable perspective about hegemony, resistances and political changes in the current crisis.
Editorial
Authors: De Riba Mayoral Silvia , Estalayo Bielsa Paula
Published: September 2020

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Racial and Ethnic Differences in Behavioral Problems and Medication Use Among Children With Autism Spectrum Disorders
Authors: Quebles Irina , Solomon Olga , Smith Kathryn A. , Rao Sowmya R. , Lu Frances , Azen Colleen , Anaya Grace , Yin Larry
Published: September 2020

We examined racial and ethnic differences in the prevalence of behavioral problems measured by the Child Behavioral Checklist (CBCL), sleep disturbances measured by the Child Sleep Habits Questionnaire (CSHQ), and medication use among children with Autism Spectrum Disorders (ASD). We analyzed data from the Autism Treatment Network (ATN) dataset for 2,576 children ages 6 to 18 years of age diagnosed with ASD. Multivariable logistic regression accounting for age, gender, Diagnostic and Statistical Manual of Mental Disorders (4th Edition – Text Revision), diagnosis (Autistic Disorder, PDD-NOS, Asperger's Disorder), and parents' education did not show any racial or ethnic differences in behavioral challenges, conduct problems, or sleep disturbances for any of the groups, but Black children had lower odds of Total Problem Behaviors and Asian children had lower odds of Hyperactivity compared to White children. As a group, children from racial and ethnic minorities had lower odds of Total Problem Behaviors and Conduct Problems compared to White children. Hispanic children had lower odds of medication use for Behavioral Challenges, Total Problem Behaviors, Hyperactivity, and Conduct Problems. Asian children had lower odds of medication use for Behavioral Challenges, Total Problem Behaviors, and Hyperactivity; and had close to lower odds in medication use for Conduct Problems. Black children had lower odds for medication use for Total Problem Behaviors only. As a group, children from racial and ethnic minorities had lower odds for medication use for Behavioral Challenges, Total Problem Behaviors, Hyperactivity, and Conduct problems, but not for Sleep Disturbances. While these results are consistent with previous studies showing that White children are significantly more likely to receive psychotropic medication compared to children from racial and ethnic minority groups, we found no such differences for sleep challenges, suggesting that they are more consistently identified and equitably treated than other behavioral problems associated with ASD. We draw upon Andersen's (1995) Behavioral Model of Healthcare Use to suggest predisposing, enabling, and needs factors that may contribute to this pattern of racial and ethnic differences in the use of medications among children ASD.
3D printed waveguides based on photonic crystal fiber designs for complex fiber-end photonic devices
Authors: Bertoncini Andrea , Liberale Carlo
Published: September 2020

Optical waveguide segments based on geometrically unbound photonic crystal fiber (PCF) designs could be exploited as building blocks to realize miniaturized complex devices that implement advanced photonic operations. Here, we show how to fabricate optical waveguide segments with PCF designs by direct high-resolution 3D printing and how the combination of these segments can realize complex photonic devices. We demonstrate the unprecedented precision and flexibility of our method by fabricating the first-ever fiber polarizing beam splitter based on PCFs. The device was directly printed in one step on the end-face of a standard single-mode fiber and was 210 µm long, offering broadband operation in the optical telecommunications C-band. Our approach harnesses the potential of high-resolution 3D printing and of PCF designs paving the way for the development of novel miniaturized complex photonic systems, which will positively impact and advance optical telecommunications, sensor technology, and biomedical devices.
Empiric Versus Clarithromycin Resistance–Guided Therapy for Helicobacter pylori Based on Polymerase Chain Reaction Results in Patients With Gastric Neoplasms or Gastric Mucosa-Associated Lymphoid Tissue Lymphoma: A Randomized Controlled Trial
Authors: Kim Jue Lie , Cho Soo-Jeong , Chung Su Jin , Lee Ayoung , Choi Jinju , Chung Hyunsoo , Kim Sang Gyun
Published: September 2020

INTRODUCTION:

We investigated to compare the effect of empirical therapy vs clarithromycin resistance–guided tailored therapy (tailored therapy) for eradication of Helicobacter pylori.

METHODS:

In this prospective, single center, open-label randomized controlled trial, we enrolled 72 patients with H. pylori infection from January 2019 through June 2019 in Korea. The patients were randomly assigned to both groups received empirical (n = 36) or tailored therapy (n = 36). Empirical therapy was defined as triple therapy with esomeprazole, amoxicillin, and clarithromycin for 10 days irrespective of clarithromycin resistance. Tailored therapy was triple or quadruple therapy with esomeprazole, metronidazole, tetracycline, and bismuth for 10 days based on genotype markers of resistance determined by gastric biopsy. Resistance-associated mutations in 23S rRNA were confirmed by multiplex polymerase chain reaction. Eradication status was assessed by 13C-urea breath test, and the primary outcome was eradication rates.

RESULTS:

H. pylori was eradicated in 27 patients (75.0%), given empirical therapy and 32 patients (88.9%) treated with tailored therapy (P = 0.136) in intention-to-treat analysis. In per protocol analysis, the eradication rate was 97.0% and 81.8% in tailoredvs empirical groups (P = 0.046). Although clarithromycin-resistant H. pylori was eradicated in 3/9 (33.3%) with empirical therapy, it was treated in 11/12 (91.7%) with tailored therapy (P = 0.009). There was no difference in compliance between 2 groups. The rate of adverse events of the tailored group was higher than that of the empirical group (P = 0.036) because quadruple therapy had more side effects than those of triple therapy (P = 0.001).

DISCUSSION:

Tailored therapy based on polymerase chain reaction is a good alternative to increase eradication rates in a region of high prevalence of clarithromycin resistance (see Visual Abstract, Supplementary Digital Content 1, http://links.lww.com/CTG/A342).
The role of molecular testing in thyroid tumors
Authors: Kachko Vera A. , Platonova Nadezhda M. , Vanushko Vladimir E. , Shifman Boris M.
Published: September 2020

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; Endocrinology Research Centre, Moscow, Russia
Thyroid cancer is the most common endocrine gland cancer. In the last few decades, the molecular diagnostics for thyroid tumors have been widely researched. It is one of the few cancers whose incidence has increased in recent years from microcarcinomas to common, large forms, in all age groups, from children to the elder people. Most researches focus on the genetic basis, since our current knowledge of the genetic background of various forms of thyroid cancer is far from being complete. Molecular and genetic research has several main directions: firstly, differential diagnosis of thyroid tumors, secondly, the prognostic value of detected mutations in thyroid cancer, and thirdly, targeted therapy for aggressive or radioactive iodine-resistant forms of thyroid cancer. In this review, we wanted to update our understanding and describe the prevailing advances in molecular genetics of thyroid cancer, focusing on the main genes associated with the pathology and their potential application in clinical practice.
Vicente de Mello
Authors: Eboli Nogueira Pedro Caetano
Published: September 2020

O presente artigo se destina a analisar os trabalhos contidos em duas exposições individuais do fotógrafo Vicente de Mello ocorridas simultaneamente no Rio de Janeiro no ano de 2018. Tratam-se de In Orbit​, ​exibida entre os dias 25 de maio e 6 de agosto na Galeria Lurixs, e curada por Ivo Mesquita; e Monolux​, que ocupou o MAM entre 17 de março e 9 de setembro, com curadoria de Eucanaã Ferraz. Compreendemos de que modo a poética do artista exerce um profundo questionamento no que concerne às relações entre a imagem e seu referente, além de acionar o caráter mnemônico e colecionista que circunvizinha o meio fotográfico. Traçamos um diálogo do trabalho do artista com algumas das vertentes mais destacadas da fotografia contemporânea, sublinhando o caráter conceitual que permeia sua obra e colocando-a em paralelo com teóricos da fotografia.
Mídia tática como conceito operativo nas artes visuais
Authors: Spíndola Motta Fernandes Thiago
Published: September 2020

Este artigo apresenta o conceito de mídia tática, seu surgimento nas formas de ativismo associadas à mídia, bem como suas raízes na ética punk e no pensamento de Michel de Certeau, com objetivo de identificar suas manifestações no campo das artes visuais, e em particular na arte contemporânea brasileira. Acreditamos que esse conceito, ainda pouco explorado por estudiosos da arte, pode ativar novos olhares para trabalhos artísticos que fazem uso subversivo e poético das mídias de massa, desviando-as de seus fins originais.
O que é contemporâneo no colecionismo de arte contemporânea?
Authors: Vargas da Rosa Nei
Published: September 2020

A questão-título do artigo parte da premissa filosófica agambeniana para pensar o que pode ser apontado como novo nos processos de institucionalização de coleções privadas de arte contemporânea no Brasil e quais contribuições estão sendo feitas para o desenvolvimento do sistema da arte. Para tanto, dados coletados em uma tese de doutoramento que investiga as repercussões sociais e artísticas dessa tipologia de instituições são cruzados com outra pesquisa organizada em metodologia qualiquantitativa e trabalho de campo que identificou colecionadoras e colecionadores nas cinco regiões do País. As pesquisas adotam a modelagem conceitual do sistema da arte como ambiente no qual as narrativas artísticas são tramadas em um complexo arranjo de fatores histórico-conjunturais, colocando em permanente confronto seus limites e noções. São abordadas as estratégias de institucionalização, suas escalas heterogêneas de atuação e o papel que desempenham, marcando a configuração e o funcionamento de diferentes modelos adotados para dar visibilidade e legitimação a coleções em um país de dimensão continental e identidades culturais multifacetadas
Cenas de Ódio, Morte e Progresso
Authors: Vieira Marco Antônio
Published: September 2020

"Cenas de Ódio, Morte e Progresso" é um polípitico instalativo que teve lugar na DeCurators, espaço de experimentação artístico-curatorial em Brasília.  A obra de João Angelini, que aqui se desdobra em quatro alegorias, aponta para a política genocida de extermínio de populações vulneráveis que marcam a lógica colonialista e tornam a história do Brasil um pesadelo alegórico. Todas as exposições da DeCurators são pensadas a partir da espacialidade da galeria. Invariavelmente, portanto, a vitrina da galeria e seu pequeno espaço interno prestam-se à mostração cênica e teatral que marcam a lógica de representação ocidental mas igualmente mergulham o sujeito do olhar na atmosferas imersiva encerrada na experiência instalativa.