bluuebunny/crossref_metadata_2025 huggingface dataset:
Sex Difference Among Patients Undergoing Semiquantitative Tc99m Sesta Mibi Myocardial Scintigraphy as a Prognostic Indicator
Authors: Abdelhamed Heba , Abdelhai Shaimaa , Abdelaziz Mahmoud , Eltahlawi Mohammad
Published: August 2022

Purpose: Coronary artery disease (CAD) and its related mortality differ between both sex. We study the sex difference in the occurrence of major adverse cardiac events (MACE) among patients undergoing MPI for the detection of CAD and the predictors of MACE among those populations.Methods: This is a prospective cohort study involving patients with known or suspected CAD undergoing MPI for ischemia evaluation from January 2018 to July 2020. All patients were subjected to resting and exercise stress ECG, Gated 99mTc-Sestamibi (MIBI) myocardial perfusion SPECT (GSPECT) using one day stress/rest protocol. All patients were followed up for 1 year or till the occurrence of cardiac event whichever was earlier.Results: one-hundred and sixty-eight patients were enrolled. The mean follow-up period was 13.8 ± 5.3 months. MACE occurred in 25 patients. There was significant difference between MACE & non-MACE groups regarding sex with more MACE among females. High SDS score, high SWTS score, DM and female sex were independent predictors for MACE.Conclusion: MACE is more among women, and female sex is an independent predictor of MACE in CAD patients. Abnormal MPI with higher SDS and SWTS scores are independent predictors for MACE. Females have different model in MACE prediction than males.
Efficient degradation of hydroquinone by a metabolically engineered Pseudarthrobacter sulfonivorans strain
Authors: Sun Haili , Tai Xisheng , Chen Yingquan , Gao Tianpeng , Zhang Wei , Liu Guangxiu , Chen Ximing , Dyson Paul
Published: August 2022

Pseudarthrobacter sulfonivorans strain Ar51 can degrade crude oil and multi-substituted benzene compounds efficiently at low temperatures. However, it cannot degrade hydroquinone, which is a key intermediate in the degradation of several other compounds of environmental importance, such as 4-nitrophenol, g-hexachlorocyclohexane, 4-hydroxyacetophenone and 4-aminophenol. Here we co-expressed the two subunits of hydroquinone dioxygenase from Sphingomonas sp. strain TTNP3 with different promoters in the strain Ar51. The strain with 2 hdnO promoters exhibited the strongest hydroquinone catabolic activity. However, in the absence of antibiotic selection this ability to degrade hydroquinone was lost due to plasmid instability. Consequently, we constructed a hisD knockout strain, which was unable to synthesise histidine. By introducing the hisD gene onto the plasmid, the ability to degrade hydroquinone in the absence of antibiotic selection was stabilised. In addition, to make the strain more stable for industrial applications, we knocked out the recA gene and integrated the hydroquinone dioxygenase genes at this chromosomal locus. This strain exhibited the strongest activity in catabolizing hydroquinone, up to 470 mg/L in 16h without antibiotic selection. Additionally, this activity was shown to be stable when the strain has cultured in medium without antibiotic selection after 20 passages.
GEO: Enhancing Combinatorial Optimization with Classical and Quantum Generative Models
Authors: Alcazar Francisco Fernandez , Perdomo-Ortiz Alejandro , Vakili Mohammad Ghazi , Kalayci Can
Published: August 2022

We introduce a new framework that leverages machine learning models known as generative models to solve optimization problems. Our Generator-Enhanced Optimization (GEO) strategy is flexible to adopt any generative model, from quantum to quantum-inspired or classical, such as Generative Adversarial Networks, Variational Autoencoders, or Quantum Circuit Born Machines, to name a few. Here, we focus on a quantum-inspired version of GEO relying on tensor-network Born machines and referred to hereafter as TN-GEO. We present two prominent strategies for using TN-GEO. The first uses data points previously evaluated by any quantum or classical optimizer, and we show how TN-GEO improves the performance of the classical solver as a standalone strategy in hard-to-solve instances. The second strategy uses TN-GEO as a standalone solver, i.e., when no previous observations are available. Here, we show its superior performance when the goal is to find the best minimum given a fixed budget for the number of function calls. This might be ideal in situations where the cost function evaluation can be very expensive. To illustrate our results, we run these benchmarks in the context of the portfolio optimization problem by constructing instances from the S&P 500 and several other financial stock indexes. We show that TN-GEO can propose unseen candidates with lower cost function values than the candidates seen by classical solvers. This is the first demonstration of the generalization capabilities of quantum-inspired generative models that provide real value in the context of an industrial application. We also comprehensively compare state-of-the-art algorithms in a generalized version of the portfolio optimization problem. The results show that TN-GEO is among the best compared to these state-of-the-art algorithms; a re- markable outcome given the solvers used in the comparison have been fine-tuned for decades in this real-world industrial application. We see this as an important step toward a practical advantage with quantum-inspired models and, subsequently, with quantum generative models.
Application of procalcitonin, C-reactive protein and white blood cell count for the rapid diagnosis of Clostridium difficile infection in patients with inflammatory bowel disease
Authors: Xie Shuhua , Wu Zhongwen , Chen Peisong , Wang Dong , Liao Kang , Liu Min , Zhang Shihong , Chen Yili
Published: August 2022

Background: The incidence of Clostridium difficile infection (CDI) has increased in recent years in patients with inflammatory bowel disease (IBD). C. difficile is a toxin-producing bacterium, and CDI results in the worsening of the underlying IBD, increasing the risks of IBD treatment failure, surgery and hospitalization. Since the symptoms of CDI overlap with those of IBD, it is challenging to make a differential diagnosis. Therefore, early, rapid and reliable diagnostic tools that can identify CDI in IBD patients would be valuable to clinicians. Methods: This study enrolled 135 patients with IBD. Among them, 44 patients were diagnosed with CDI, and 42 patients were diagnosed with viral or fungal infections; 49 patients without infections were enrolled in the control group. The diagnostic values of procalcitonin (PCT), C-reactive protein (CRP) and the white blood cell count (WBC) in the peripheral blood were examined. A receiver operating characteristic (ROC) curve was used to analyse the diagnostic value of these parameters. Results: In this study, the PCT and CRP levels were significantly higher in patients with CDI than in non-CDI patients (including patients with viral/fungal infections and the control group; p<0.001 and p<0.05, respectively). In the ROC curve analysis of the IBD-CDI group and the control group, PCT and CRP predicted IBD-CDI with an area under the curve (AUC) of 0.826 [95% confidence interval (CI) 0.743–0.909, p=0.000] and 0.663 [95% confidence interval (CI) 0.551–0.774, p=0.007], respectively. The WBC count was inferior as diagnostic tool for CDI. The sensitivity was 56.82% (95% CI: 41.03% to 71.65%), the specificity was 91.84% (95% CI: 80.40% to 97.73%), and the LR (+) was 6.96 for PCT for the diagnosis of CDI. Conclusions: The present study demonstrated the superiority of PCT over CRP and the WBC for the rapid diagnosis of CDI in IBD patients. Additionally, PCT can be used to predict the clinical outcomes.
Bioetički i kaznenopravni odgovori na specifičnosti kaznenog djela trgovanja dijelovima ljudskog tijela
Authors: Jeličić Ana , Aljinović Nevena
Published: August 2022

Trgovanje dijelovima ljudskog tijela jedno je od najsurovijih oblika zločina suvremenog doba. Aktualnost ovog fenomena pojačavaju okolnosti njegove isprepletenosti s organiziranim kriminalom i ljudskim očajem. Posljedice su trgovanja dijelovima ljudskog tijela: (I) pogibeljne za »darivatelje«; (II) prosperitetne za »posrednike«; te (III) životno uvjetovane za »primatelje«. U ovom se radu analizira fenomen trgovanja dijelovima ljudskog tijela u neposrednoj vezi s razvojem transplantacijske medicine i kirurgije. Transplantacija ljudskih organa gravitira prema indikativnoj etici odgovornosti te postepeno nadilazi imperativnu etiku dužnosti. Međutim, s etičkog i moralnog gledišta, darivanje ljudskih organa predstavlja čin sebedarja, što komercijalizaciju ljudskih organa čini neprihvatljivom jer vrijeđa ljudsko dostojanstvo. Osim etičkih implikacija, u ovom se radu analiziraju međunarodni dokumenti koji se odnose na problematiku trgovanja dijelovima ljudskog tijela te hrvatsko normativno uređenje predmetne materije, dok se zaključno iznose bioetički i kaznenopravni odgovori na razmotrenu problematiku.
Perspektive pravnih i bioetičkih razmatranja sa stajališta medicinskog prava
Authors: Mujović Hajrija
Published: August 2022

Važan predmet bioetičkih i pravnih razmatranja čine odnosi i manifestacije u aktualnoj medicinskoj praksi u pogledu obavljanja djelatnosti i pružanja usluga zdravstvene zaštite. To je naročito od značaja kada je riječ o neslaganjima, suprotstavljenim i kolizijskim pravilima, etičkom i pravnom ishodištu različitih normi, i donošenju medicinskih odluka. Neophodan je odgovarajući analitički i metodološki pristup putem tumačenja i komparacije, da bi se ustanovile manjkavosti koje zbog odsustva dijaloga često ostaju na površini, nevidljive. Cilj je ovoga razmatranja istaknuti osnove bioetičkih principa, s jedne strane, te pravno-logičkog sistema normi u medicinskom postupanju, s druge strane. Zaključak stavlja naglasak na otklanjanje kolizijskih elemenata odnosa, a afirmiranje pomažućih i dopunjujućih aspekata, s otvaranjem usporednih perspektiva i točaka presjecanja, u službi napretka zakonitosti rada, razvijanja dobre medicinske prakse i poštovanja ljudskih prava u zdravstvu.
On the separation of Hall and Ohmic nonlinear responses
Authors: Tsirkin Stepan , Souza Ivo
Published: August 2022

The symmetric and antisymmetric parts of the
linear conductivity describe the dissipative (Ohmic) and
nondissipative (Hall) parts of the current. The Hall current is
always transverse to the applied electric field regardless of its
orientation; the Ohmic current is purely longitudinal in cubic
crystals, but in lower-symmetry crystals it has a transverse
component whenever the field is not aligned with a principal axis.
In this work, we extend that analysis beyond the linear regime. We
consider all possible ways of partitioning the current at any order
in the electric field without taking symmetry into account, and find
that the Hall vs Ohmic decomposition is the only one that satisfies
certain basic requirements. A general prescription is given for
achieving that decomposition, and the case of the quadratic
conductivity is analyzed in detail. By performing a symmetry
analysis we find that in five of the 122 magnetic point groups the
quadratic dc conductivity is purely Ohmic and even under time
reversal, a type of response that is entirely disorder mediated.
Climatic projections of Western India using global and regional climate models
Authors: Shaikh Mohdzuned Mohmedraffi , Lodha Pradeep , Lalwani Prashant , Mehta Darshan
Published: August 2022

This research work aimed to project and analyze climatic variability using GCMs and RCMs in the Hathmati River Basin, which happens to be one of the most important tributaries of Western India. The analysis included a baseline period from 1980 to 2014 and a future scenario (2050s) under a representative concentration pathway (RCP4.5). Following the evaluation of bias correction methods, distribution mapping and power transformation were used for temperature and precipitation projection, respectively. The 2050 s RCP4.5 simulations showed an increase in precipitation to 1,015.54 mm from 936.91 mm giving around a 8.45% increase in average precipitation. For temperature, the maximum temperature was around a 7.05% increase taking the average temperature to 34.21 from 33.97. The minimum temperature was 20.24 from 20.41 showing a positive change of around 8.4%. The future precipitation and temperature change projected might worsen the water stress and increase the probability of the occurrence of severe events, and hence mitigation strategies and management options to reduce this negative impact should be encouraged.
Oxygen aeration efficiency of gabion spillway by soft computing models
Authors: Srinivas Rathod , Tiwari Nand Kumar
Published: August 2022

The current paper deals with the performance evaluation of the application of three soft computing algorithms such as adaptive neuro-fuzzy inference system (ANFIS), backpropagation neural network (BPNN), and deep neural network (DNN) in predicting oxygen aeration efficiency (OAE20) of the gabion spillways. Besides, classical equations, namely multivariate linear and nonlinear regressions (MVLR and MVNLR), including previous studies, were also employed in predicting OAE20 of the gabion spillways. The analysis of results showed that the DNN demonstrated relatively lower error values (root mean square error, RMSE = 0.03465; mean square error, MSE = 0.00121; mean absolute error, MAE = 0.02721) and the highest value of correlation coefficient, CC = 0.9757, performed the best in predicting OAE20 of the gabion spillways; however, other applied models, such as ANFIS, BPNN, MVLR, and MVNLR, were giving comparable results evaluated to statistical appraisal metrics of the relative significance of input parameters based on sensitivity investigation, the porosity (n) of gabion materials was observed to be the most critical parameter, and gabion height (P) had the least impact over OAE20 of the spillways.
Efficiencies and mechanism of enhanced coagulation pre-treatment on domestic sewage with PAC-HCA compound
Authors: Yan Zichun , Shen Li , Pei Zhibing , Yang Mingxia , Zhang Wei
Published: August 2022

Poly dimethyl diallyl propyl ammonium chloride (HCA) and poly aluminum chloride (PAC) were used to prepare complex coagulants for the enhanced coagulation (EC) pretreatment of domestic sewage. The influences of hydraulic conditions, the dosage ratio of PAC-HCA complex coagulants, initial pH value, and dosage on the removal efficiency of SS, COD, and TP in domestic sewage were investigated. The fractal dimension and Zeta potential were used to verify and characterize the experimental results. The results showed that the optimum coagulant conditions were as follows: G1 = 200.0–265.0 s−1, T1 = 1.5 min, G2 = 40.0 s−1, T2 = 5 min, PAC: HCA = 25:1, dosage = 15 mL/L, pH = 8. At the mentioned point, the removal rates of SS, COD, and TP are 98.74%, 44.63%, and 89.85%, respectively. In addition, through comparative tests, PAC-HCA compound coagulants show better treatment efficiency than PAC and HCA used alone. When the HCA dosage was 15 mg/L, Zeta potential and flocs fractal dimension was 2.29 mv and 0.9844, respectively. This indicates that PAC-HCA has a good treatment effect on domestic sewage, and the mechanism of enhanced coagulation to remove nutrients is mainly electrical neutralization.
Comparativo de tipo de mensaje ante el conflicto en estudiantes de telesecundaria y colegio católico
Authors: De la Rosa Vazquez Cecilia Sarahi , Garza-Sánchez Rosa Isabel
Published: August 2022

La agresividad, evitación y cooperatividad son tres estilos de comunicación ante el conflicto, siendo esta última la idónea para la solución de conflictos mediante la paz. El objetivo de la investigación fue identificar diferencias significativas entre el tipo de mensaje ante el conflicto de los estudiantes de un colegio católico privado y una telesecundaria pública de la ciudad de Saltillo Coahuila, México. En el estudio participaron 203 alumnos mexicanos de secundaria con edades que van desde los 11 hasta los 16 años (M=13,06, DE=0,9). El instrumento utilizado fue el Conflictalk, que incluye 3 componentes: agresividad (compuesta por 6 ítems); cooperatividad (compuesta por 6 ítems) y evitativo (compuesto por 6 ítems). La fiabilidad fue 0,785 según el coeficiente de alfa de Cronbach. El procedimiento de recolección de datos fue mediante una encuesta autoaplicada a partir de un muestreo no probabilístico de tipo intencional. Los datos se analizaron con estadísticos descriptivos y comparativos mediante la prueba U de Mann-Whitney a un nivel de significancia p<0,05. Los resultados arrojaron diferencias significativas en los componentes de agresividad y evitación a favor de la telesecundaria pública y un estilo cooperativo más presente en las mujeres.
ANALYSIS OF THE EFFECT OF PRACTICE AND SUPPLY CHAIN INTEGRATION ON OPERATIONAL PERFORMANCE OF SMEs IN MALANG CITY
Authors: Yoga Tirta , Koestiono Djoko , Wahyuningtyas Agustina Shinta Hartati
Published: August 2022

This study was conducted to evaluate the practice of implementing Supply Chain Management (SCM) and Supply chain Integration (SCI) on operational performance in Small and Medium Enterprises (SMEs) in Malang City. This study aims to determine the effect of SCM practices on supply chain integration, the effect of SCM on operational performance, and the effect of supply chain integration on operational performance. Data collection in this study was carried out by distributing 100 questionnaires to owners or managers of SMEs in Malang City which the criteria are food and beverage agro-industry SMEs located in Malang City and have carried out supply chain management (SCM) activities for at least 1 year. The analytical method used in testing the research hypothesis is using multiple regression. The results of the study found that 1) there is a positive influence of supply chain management practices on operational performance, 2) there is a negative influence of supply chain integration on operational performance, 3) supply chain management practices and supply chain integration simultaneously have a positive effect on operational performance in SMEs in the Malang City.
THE INFLUENCE OF CUSTOMER VALUE ON MARKETING PERFORMANCE FOR SMALLHOLDER RUBBER FARMERS IN KUANTAN MUDIK DISTRICT, KUANTAN SINGINGI REGENCY
Authors: Huda Washilatul , Khaswarina Shorea , Kusumawaty Yeni
Published: August 2022

The success of customer value can affect the marketing performance of rubber. The research was conducted in Kuantan Mudik District, Kuantan Singingi Regency, Riau. The purpose of this study was to determine the effect of customer value on emotional value, social value, quality value, and price value on smallholder rubber farmers. The population in this study were 205 farmers, the sample was taken 15% of the population of 31 farmers selected by simple random sampling technique. Analysis of the data used is multiple linear regression analysis with SPSS application. The results of the study explain sig.t value for X1 is 0.003, sig.t value of X2 is 0.014, sig. t value of X3 is 0.021 which is smaller than the 0.05 level of significance. This means that X1, X2, and X3 partially have a significant effect marketing performance. While sig t value of X4 is 0.216 which is greater than the significant level, means price value partially has no significant effect marketing performance. f-test results sig.f value of 0.000 is smaller than the significant level of 0.05, meaning that the customer value seen from the emotional, social, quality, and price values simultaneously has a significant effect on increasing marketing performance.
Dampak Ruang Terbuka Hijau Terhadap Lingkungan Mikro Di Kawasan BSD (Bumi Serpong Damai) City Kota Tangerang Selatan (Studi Kasus di Taman Kota 1 dan Taman Kesehatan)
Authors: Azka Aulia Muhammad , Ariffin Ariffin
Published: August 2022

BSD City adalah salah satu kawasan di kota Tangerang Selatan yang memiliki berbagai fasilitas untuk kemudahan mobilitas penghuninya. Dibangunnya berbagai macam fasilitas memicu pada tergerusnya area terbuka di kawasan tersebut. Tujuan penelitian ini ialah untuk mempelajari ruang terbuka hijau (RTH) terhadap pembentukan lingkungan mikro serta menentukan RTH yang berkontribusi lebih besar dalam pembentukan lingkungan mikro di antara Taman Kota 1 dan Taman Kesehatan di Kawasan BSD City. Penelitian dilaksanakan pada bulan Oktober – Desember 2020 di Taman Kota 1 dan Taman Kesehatan BSD City Kota Tangerang Selatan. Adapun alat dan bahan yang digunakan selama proses penelitian yakni berupa thermohygrometer HTC-2, luxmeter ASA-803, anemometer GM816, meteran, kamera ponsel, alat tulis, serta peta kota Tangerang Selatan dan peta kedua RTH. Metode penelitian yang digunakan yakni metode observasi dengan purposive sampling Hasil penelitian menunjukkan bahwa baik Taman Kota 1 BSD maupun Taman Kesehatan BSD mampu membentuk lingkungan mikro yang baik. Taman Kota 1 mampu membentuk lingkungan mikro yang lebih baik dibandingkan dengan Taman Kesehatan. Hal tersebut ditunjukkan dengan lebih rendahnya suhu udara, lebih tingginya nilai RH, serta lebih rendahnya intensitas cahaya matahari. Sementara laju kecepatan angin di antara keduanya masih relatif sama. Lingkungan mikro di dalam masing-masing RTH juga terbukti mampu memberikankontribusi lebih terhadap lingkungan mikro dibandingkan lingkungan mikro di luar RTH.
Pengaruh Berbagai Komposisi Media Tanam Pada Pertumbuhan dan Hasil Tanaman Bawang Merah (Allium ascalonicum L.) Varietas Bauji
Authors: Damayanti Erlinda , Barunawati Nunun
Published: August 2022

Komoditas Bawang Merah memiliki peluang bisnis yang besar di Indonesia. Sebagai salah satu bahan pokok, bawang merah memiliki beragam manfaat mulai dari bumbu masakan hingga produksi obat herbal. Karena manfaat dan kebutuhan yang beragam inilah membuat tingkat konsumsi bawang merah di Indonesia tinggi. Namun produksi belum mampu memenuhi kebutuhan pasar. Tujuan dari penelitian ini ialah mendapatkan komposisi media tanam yang tepat untuk pertumbuhan dan hasil tanaman bawang merah varietas Bauji. Penelitian ini dilaksanakan pada bulan Maret sampai Mei 2021 di Kelurahan Cinambo, Kecamatan Cisaranten Wetan, Kota Bandung, Jawa Barat dengan menggunakan Rancangan Acak Kelompok non Faktorial dengan 3 kali pengulangan. Terdapat 10 perlakuan kombinasi media tanam ialah P1 = Media tanah : pupuk kandang kambing : pasir (1 : 2 : 1) P2 = Media tanah : pupuk kandang kambing : pasir (1 : 1 : 2) P3 = Media tanah : pupuk kandang kambing : pasir (1 : 1 : 1) P4 = Media tanah : pupuk kandang kambing : pasir (2 : 1 : 1) P5 = Media tanah : pupuk kandang kambing : pasir (2 : 2 : 1) P6 = Media tanah : pupuk kandang sapi : pasir (1 : 2 : 1) P7= Media tanah : pupuk kandang sapi : pasir (1 : 1 : 2) P8 = Media tanah : pupuk kandang sapi : pasir (1 : 1: 1) P9 = Media tanah : pupuk kandang sapi : pasir (2 : 1 : 1) P10= Media tanah : pupuk kandang sapi : pasir (2 : 2 : 1). Penelitian dilakukan secara distruktif dan non distruktif. Hasil penelitian menunjukan bahwa perbedaan komposisi media tanam tidak memberikan pengaruh nyata pada pertumbuhan dan hasil tanaman bawang merah kecuali pada luas daun. Hal ini dapat dimungkinkan bahwa varietas Bauji lebih sesuai dibudidayakan di daerah dataran rendah sampai dataran sedang.
Acceptance of family caregiving in the older adults: A validation of theory through a descriptive correlational study
Authors:   College of Nursing, Angeles University Foundation, Angeles, Philippines, et al. Feliciano
Published: August 2022

This descriptive correlational study on theory validation aimed at validating one of the propositions of the theory that states, “Family caregiving trajectory is influenced by factors such as resources” with a purposive sample of 304 family caregivers in Pampanga. To facilitate the validation of the proposition, the study aimed to determine the correlation between the older adults and family caregivers' characteristics with family caregiver burden using an instrument composed of the socio-demographic profile, Barthel Index (BI) of independence, caregiving self-efficacy scale, and Zarit burden interview scale. Caregiver burden was predicted by the identified older adults’ and caregivers’ characteristics by 28.1% with respect to the R square value of 0.281. Of all identified characteristics of the older adults and family caregivers, co-morbidity presence (p=.027; B=-3.641), lack of financial support (p=.009; B=5.539), decreasing level of independence (p=.000; B=-0.134) and low efficacy in the control of upsetting thoughts (p=.000; B=-2.359) were predictive of caregiver burden. The negative connotation related to aging and “everlasting caregiving” showed a relative interest in understanding caregiver burden experience. The resources, while infused on older adults’ and family caregivers’ characteristics showed a good prediction of older adults’ independence level, financial support and presence of co-morbidities, and family caregivers’ self-efficacy towards caregiver burden. Therefore, resources come from various forms, and they play an integral part in impacting a successful family caregiving trajectory.
The Beneficial and Adverse Effects of Phytoestrogens
Authors:   Department of Surgical Research and Techniques, The Heart and Vascular Center, Semmelweis University, Faculty of Medicine, Budapest 1089, Nagyvárad square 4., Hungary, Blázovics Anna , Csorba Botond ,   Eötvös Loránd Bilingual Primary School, Százhalombatta 2440, Liszt Ferenc walk 2., Hungary, Ferencz Andrea ,   Department of Surgical Research and Techniques, The Heart and Vascular Center, Semmelweis University, Faculty of Medicine, Budapest 1089, Nagyvárad square 4., Hungary
Published: August 2022

The most well-known phytoestrogens (flavonoids, isoflavonoids, lignans, coumestans, stilbenes, and prenylflavonoids) are isoflavonoids, which are important active ingredients in medicinal and food plants. They are highly abundant in the Fabaceae family. More than 1,000 types of isoflavonoids have been isolated from nearly 300 kinds of plants, and more are being discovered through modern analytical methods. Glycosides O and C of isoflavonoids are poorly absorbed in the intestine. They are converted by bacterial esterases and/or β-glycosidase enzymes to aglycones, which are absorbed more efficiently. Their bioavailability shows significant differences due to variation in the intestinal microflora of various races. The compounds formed during their biotransformation are structurally similar to estrogens. In Traditional Chinese medicine, several herbs rich in phytoestrogens are used to prevent and cure various diseases, such as osteoporosis, cardiovascular diseases, diabetes mellitus, hypertension, hyperlipidemia, tumors, and inflammation; additionally, 185 herbs are used to treat menopausal symptoms. Some of these herbs can be used to alleviate the unpleasant symptoms of menopause and treat breast and prostate cancer. From a nutritional physiology perspective, the consumption of Glycine max and Vigna unguiculata should be emphasized. Soy has been consumed in China for about 5,000 years while it was introduced to Europe nearly 300 years ago. Soybean cultivation in Hungary dates back only 100 years. The assessment of the efficacy of phytoestrogens is unclear. Although several experimental and molecular biology studies have shown favorable results, studies on humans have not shown prominent therapeutic benefits. However, comparing and interpreting the findings of modern studies might elucidate the therapeutic utility of phytoestrogens.
From the Cochrane Library: Visual Inspection and Dermoscopy, Alone or in Combination, for Diagnosing Keratinocyte Skin Cancers in Adults (Preprint)
Authors: Klein Colleen M , Sivesind Torunn E , Dellavalle Robert P
Published: August 2022

UNSTRUCTURED
The Practice of Research Innovation in Higher Learning Institutions: Implication for Quality Education Mwanza-Tanzania
Authors: Gerold Mkulu Demetria
Published: August 2022

This study explored practice of research innovation in higher learning institutions; implication for quality Education. Higher learning with high provision of research activities would attract finance from different agencies. Globally, research exploration contributes significant benefits to society. The study posed three objectives: to identify roles of research in higher learning institutions in Mwanza, determine areas for research innovation in higher learning, to examine possible strategies to curb challenges facing research innovation. Three higher learning institutions in Mwanza city were involved. The research adopted mixed paradigms. A number of 140 respondents were involved in the study. The study adopted cross-sectional survey design, which allows the researcher to visit the field in a single point of time, collect both narrative and quantitative information concurrently, analyze separately and merge it at the end of the study. Data gathering were questionnaires, descriptive guide, and observation. Instruments were validated, piloted; the result indicated 0.81 Cronbach Alpha demonstrating that tools were acceptable. Information was coded using descriptive statistics with the assistance of the package for Social Sciences (SPSS) Version 21. Narrative data was subjected to word clouds program. Various themes emerged and used in report writing. The findings displayed that; research enables learners to be critical thinkers, problem solvers, empower the youths, gives self-confidence, it gives autonomy and provides monetary funds. However, were varieties of challenges facing research innovation as monetary capital, lack of institutional partnership and low learners registration. Hence, government should set policy that would ensure research is given paramount priority in all learning.
PHYTOCHEMICAL ANALYSIS AND SCREENING THE BIOLOGICAL ACTIVITIES OF UNRIPE PODS OF PONGAMIA GLABRA VENT
Authors: RAVISANKAR NARAYANAN , KAYALVIZHI R. , BHARATHI KUPPUVELSAMY VANITHA
Published: August 2022

Objective: Pongamia glabra vent is widely used in folk medicine. The chemicals found in these have gained prominence in various studies. The phytochemical constituents of the benzene extract of the unripe pods of Pongamia Glabra Vent were investigated qualitatively and quantitatively using standard methods.
Methods: The compounds belonging to the group of flavonoids were isolated from benzene extracts of unripe pods of Pongamia Glabra Vent.
Results: A total six known natural compounds were separated and purified by chromatography techniques and five compounds were isolated and identified as flavonoid derivatives such as lanceolatin B, Karanjin, Pongapin, Kanjone, Pinnatin and the other one is a furanodibenzoyl methane namely Pongamol.
Conclusion: Physical studies such as UV, IR, 1H and 13C NMR, Mass and Element analysis have been used to confirm the structures of the isolated compounds. In the study, all compounds exhibited strong antibacterial activity against selected bacteria and fungi. The compound of C06 showed better antioxidant performance compared to standard ascorbic acid and butylated hydroxytoluene.
PHYSIOCHEMICAL, IN-VITRO, EX-VIVO AND IN-VIVO EVALUATION OF TRANSDERMAL PATCHES BASED ON QBD APPROACH: AN OVERVIEW
Authors: DUBEY RUPAL , POTHUVAN UMADOSS , PANDEY ARUN KUMAR , GUPTA BHASKAR KUMER
Published: August 2022

There are various forms of prescription drugs available in the market for human and animal purposes, which may be administered for acute or chronic treatment. And a variety of dosage regimens of different dosage forms are found in general, among which one of the treatment modes is the transdermal route. The Transdermal Tract Route is a more accurate way to get into the skin without pain, faster to systemic circulation than the oral route and the drug reaches the systemic circulation in a controlled transmission.
Improving the transdermal system poses an additional challenge to maintain Quality by Design (QbD) with quality, consistency, reproduction, stability and efficiency. With the QbD method of pharmaceutical product production, product quality is considered much faster than waiting until the end to be tested for quality. In essence, this includes determining the sources of the unpredictability that may be contributing to the process. This approach ensures that the causes of quality problems are identified. The main result is a pharmaceutical product manufactured to meet pre-determined quality requirements from the outset.
In essence, this includes determining the sources of the unpredictability that may be contributing to the process. This approach ensures that the causes of quality problems are identified. The main result is a pharmaceutical product manufactured to meet pre-determined quality requirements from the outset.
Critical quality attribute (CQA) and Critical Process Parameters can be used to establish QbD (CPP). During the construction of a transdermal design, it is important to check the various key parameters that help maintain the Quality Target Product Profile (QTPP) of the drug product.
ANTI-INFLAMMATORY POTENTIAL OF ALOE VERA IN ORAL MUCOSITIS THERAPY: SYSTEMATIC REVIEW
Authors: CHANDRA VERRELY CHRISTIAN , NUR’AENY NANAN , WAHYUNI INDAH SUASANI
Published: August 2022

This review aims to analyse the potency of Aloe vera for Oral Mucositis (OM) therapy. Articles searched using the keywords “Oral Mucositis” AND “Aloe vera”, conducted through PubMed, ScienceDirect, and Cochrane Library databases, and adapted to the PICO (Population, Intervention, Comparison, Outcome) framework. The inclusion criteria for articles were: Randomized Controlled Trial (RCT) study design; in English; full paper available; published in the range between 2011-2021 and with low risk of bias. RoB-tools JADAD Oxford Quality Scoring System was used. This paper writing refers to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. A total of 5 (five) articles met the criteria for a qualitative review and all showed a high range of quality articles. It was found that both Aloe vera solution 70% and Aloe vera gel 10% showed a reduction of radiotherapy or chemotherapy-induced oral mucositis grade. Aloe vera mouthwash has an equal anti-inflammation effect compare to benzydamine on the patient with radiotherapy-induced oral mucositis, whereas the use of other formula containing Aloe vera with other herbal materials did not show an anti-inflammatory effect. Drug formulation containing Aloe vera can be used as an alternative therapy in the management of Oral Mucositis (OM) with anti-inflammatory potency that can reduce pain and the severity of oral mucositis.
A COMPARATIVE PHYSICO CHEMICAL ANALYSIS OF AMṚTOTTARA KVATHA AND IT’S PRAVAHI KVATHA
Authors: S. SREELAKSHMI , MOHANAN ARUN , P. K VINEETH
Published: August 2022

Objective: Herbal decoctions are commonly used pharmaceutical dosage form in Ayurveda. The major drawback of decction is short shelf life. To increase the shelf-life preservatives are used. The effectiveness of decoctions added with preservative is not evaluated yet. Pravāhi kvātha is fermented decoctions prepared to increase the shelf life as well as the palatability of decoctions. In the present study, an attempt has been made compare the efficacy of freshly prepared herbal decoction, decoction added with preservative and fermented decoction.
Methods: To compare the efficacy, the three samples were subjected to analytical study through organoleptic, physicochemical and other advanced chromatographic and instrumental analysis. For scientifically validating the effectiveness the samples were analysed for Physico chemical parameters, HPTLC, Gallic acid estimation, HR LC-MS and DPPH assay.
Results: After the physico chemical analysis it was found that the parameters of three samples was within permissible limit. The anti-oxidant potential of three samples were proved by the DPPH free radical scavenging activity. The I50 value of three samples shows only less variation and all the sample possess good anti-oxidant potential. Phyto chemical evaluation of the three samples were compared wit HPTLC, Gallic acid estimation and HR LCMS analysis.
Conclusion: The study shows that the modification of Kaṣāya to Pravāhi Kvātha will not affect its therapeutic efficacy rather it adds more therapeutic value due to the presence of newly synthesized compounds. Addition of Sodium benzoate preservative doesn’t alter the therapeutic efficacy of Amṛtottara Kaṣāya and it won’t produce any toxic chemicals by the interaction with drugs.
GCMS ANALYSIS ON ANDROGRAPHIS PANICULATA SEED EXTRACT AND ITS ANTICANCER ACTIVITY
Authors: S. RAJESWARI , R. VIDYA , P. AMUDHA
Published: August 2022

Objective: Andrographis paniculata was an ancient medicinal herb recorded in Ayurvedic system of medicine from long times. The present study is to determine the bioactive phytocomponents present in Andrographis paniculata seed, extraction done using ethanol and Human Liver Cancer (HepG2) cells are used to prove the anticancer activity.
Methods: Gas Chromatography-Mass Spectroscopy (GCMS) analysis is used for determining the bioactive constituents of the Andrographis paniculata seed. To prove the in vitro anticancer activity, the MTT assay was done on Human Liver Cancer (HepG2) cells.
Results: GCMS analysis of Andrographis paniculata seed extract result determined the presence of 15 active bio components. These various potent bioactive compounds have been proved to possess various pharmacological activities, viz., antimicrobial, antidiabetic, antioxidant, anti-inflammatory and anticancer properties, which were supported by previous findings. The natural compounds with therapeutic effects on traditional medicine have paved the way for evaluating the Andrographis paniculata seeds for cytotoxic activity on HepG2 cell lines. The ethanol extract of Andrographis paniculata seeds was used on HepG2 to evaluate the cytotoxicity; Cisplatin (15 µg/ml) is used as standard with various concentration like 200, 100, 50 and 25 µg/ml were used. The bioactive compounds present in Andrographis paniculata seed extract revealed significant cytotoxicity activity against HepG2 cells with IC50 value of 103.03µg/ml.
Conclusion: The cytotoxic effect was found to be concentration-dependent and increased concentration of Andrographis paniculata seed extract showed increased cytotoxicity. The result suggest Andrographis paniculata seed extract have bioactive agents which when treated on hepatocellular carcinoma cells poses excellent anticancer activity.
IN VITRO ANTICANCER, ANTIOXIDANT AND MOLECULAR DOCKING STUDIES OF 4-AMINOBENZAMIDE METAL COMPLEXES
Authors: NARASIMHAVARMAN S. , RAJASEKAR K. , MANDAL SUDIP KUMAR , SELVARANI R. , VEERAVEL C.
Published: August 2022

Objective: Mixed ligand complexes of Cu(II) and Cd(II) with 4-aminobenzamide(4-ABZ) have been synthesized under microwave irradiation and they were characterized by elemental analysis, estimation of metal ion, molar conductivity, magnetic study, FT-IR, Far-IR, electronic spectra, NMR (1H and 13C) and EPR spectral studies. 
Methods: The data of microanalysis and metal estimation showed that the complexes have the composition of [M(L1)2(L2)2] for Cu(II) and [M(L1)(L2)2] for Cd(II) complex respectively. The conductivity data confirmed the neutral nature of the complexes. The tetrahedral geometry of the Cd(II) complex was confirmed using UV-Visible spectra. The tetragonally distorted octahedral stereochemistry of Cu(II) complex was further confirmed by UV and EPR spectral studies. The diamagnetic nature and probable geometry of Cd(II) complex were also confirmed using NMR spectral studies, which are also compared with free 4-aminobenzamide. The in vitro bio-potential activities of 4-ABA and Cd(II) complex were screened for E. coli and C. Albicans microorganisms by Agar disc diffusion methods. 
Results: The cancer study of Cu(II) complex and antioxidant activity of DPPH free radical scavenging method of Cd(II) complex were measured and compared with 4-aminobenzamide and standard drugs. The breast cancer studies were also identified using the targeted proteins viz., BRCA1, PR and EGFR by molecular docking study.
Conclusion: In the present study, we synthesized new metal complexes of Cu(II) and Cd(II) with 4-ABA and nitrite ion by microwave irradiation method. The analytical data show that the metal-ligand stoichiometry they are non-electrolytes in acetonitrile solution. The spectral data show that the synthesized ligand binds with metal ions through the nitrogen atom of the 4-ABA and oxygen atoms of the nitrite ion.
DEVELOPMENT AND IN VITRO EVALUATION OF VALSARTAN-LOADED RESEALED ERYTHROCYTES
Authors: ELHASSAN GAMAL OSMAN , MOHAMED JAMAL MOIDEEN MUTHU
Published: August 2022

Objective: Resealed erythrocyte technique has attempts for preparation of valsartan loaded reservoir type using red blood cell as a carrier.

Methods: The resealed erythrocytes were prepared by using glutaraldehyde as a cross-linking agent by Preswell dilution technique and sodium chloride as the medium has been made to predict mechanism of drug release and absorption based on the order of release. The prepared resealed erythrocytes was characterised as a percentage of cell recovery drug content, osmotic shock, turbulence fragility, osmotic fragility, in vitro drug release studies, and hemoglobin content study.

Results: The result of the study showed that the resealed erythrocytes prepared with sodium chloride (9 %) showed biconcave shape, an assay of 6.5±0.4 %, osmotic shock (0.028±0.004 µg/ml), turbulence fragility of 0.228±0.046 µg/ml, and 44.38±5.54 % drug release in 8 h. The drug release kinetics was studied and found that release from spherical matrices, first-order model with non-fickian diffusion with and the dissolution occurs in planes that are parallel to the drug surface pattern.

Conclusion: VaL administration could be avoided the number of drawbacks associated with systemic delivery and perhaps maintain a relatively constant plasma level during a lengthy course of treatment.
El T-MEC y la tercera generación de arreglos laborales: De las experiencias previas en Latinoamérica al futuro previsible para las relaciones industriales mexicanas
Authors: Covarrubias V. Alex , Dufour-Poirier Mélanie
Published: August 2022

En Norteamérica existe un nuevo marco normativo dirigido a replantear los términos de intercambio comercial entre Canadá, México y Estados Unidos, y a incidir en sus relaciones laborales. El estudio se dirige a evaluar las condiciones como se está produciendo el tránsito hacia un nuevo modelo laboral en México, partiendo de la experiencia previa y seis acuerdos comerciales de Estados Unidos con 11 países de América Latina y el Caribe. La evidencia reunida muestra que los cambios hasta ahora producidos son limitados y focalizados en industrias estratégicas trasnacionales como la automotriz. Se postula entonces que sólo ocurrirá una transformación de las relaciones laborales si y solo si los cambios legislativos son respaldados y procesados por los diferentes stakeholders involucrados –i.e., una orquestación desde abajo que pueda extenderse y ser respaldada por la sociedad civil.
Automatic Speech to Sign Language Software for Translation (ASSiST) for Hearing-Impaired
Authors: Sahetya Divya N , Bhojraj Nandlal , T Shreekanth , Singhania Shreepriya , Bijlani Samhita
Published: August 2022

Abstract: A total of 63 million people in India have hearing impairment, which is a common cause of disability. Due to communication barriers, these individuals are at risk for reduced cognitive skills and language deficits which may contribute to their poor general and oral health. Instructing these individuals regarding oral health concerns, treatment options and prognosis is often challenging for dental professionals. An Automatic Speech to Sign Language Translation Software (ASSiST) was developed to improve brushing technique among children with hearing impairment. The programming of Automatic Speech Recognition (ASR) system was done using Linear Predictive coding (LPC) algorithm for extraction of Speech Signals and Artificial Neural Networks as a classifier and recognizer. This tool is tested to help imparting oral hygiene instructions in the form of a sequence-based brushing technique to the children chair side which when spoken by the dentist translates it into the respective regional sign language which is displayed on the screen.
Pengaruh Penggunaan Campuran Minyak Sawit dan Olein Sawit terhadap Sifat Fisikokimia dan Sensori Selai Cokelat
Authors: Hasibuan Hasrul Abdi , Hardika Aga Prima , Hendrawan Wawan
Published: August 2022

Minyak sawit merupakan minyak nabati berbentuk semi padat yang berpotensi digunakan sebagai lemak dalam pembuatan selai cokelat. Di samping itu, fraksi cair minyak sawit berupa olein sawit (super olein) dapat meningkatkan daya oles selai cokelat. Penelitian ini dilakukan untuk mengkaji sifat fisiko kimia dan sensori selai cokelat menggunakan campuran minyak sawit dan olein super pada rasio 71,4:28,6, 57,1:42,9, 42,9:57,1 dan 28,6:71,4. Formula selai cokelat yang dibuat yaitu lemak 35%, gula 44,6%, kakao bubuk 10%, susu bubuk 10%, lesitin 0,32%, garam 0,03% dan vanilla 0,05%. Selai cokelat dikarakterisasi meliputi ukuran partikel, kadar lemak, titik leleh, komposisi asam lemak, komposisi triasilgliserol dan kandungan lemak padat serta uji organoleptik. Ukuran partikel dan kadar lemak tidak berbeda nyata sedangkan titik leleh lemak, komposisi asam lemak, komposisi triasilgliserol dan kandungan lemak padat berbeda nyata pada setiap formula. Dari hasil uji organoleptik menunjukkan bahwa jumlah olein super yang lebih banyak (71,4%) lebih disukai oleh panelis. Pada formula tersebut, selai cokelat memiliki ukuran partikel 0,08 mm, kadar lemak 40,0%, titik leleh lemak 19,2°C, komposisi asam lemak (asam palmitat 38,3%, asam stearat 6,7%, asam oleat 42,2%, dan asam linoleat 9,9%), komposisi triasilgliserol (POP 35,9%, PLP 10,0%, POS 7,7%, POO 25,2% dan PLO 7,3%), serta kandungan lemak padat pada suhu 25°C dan 30°C masing-masing sebesar 5,4% dan 2,1%.
GAYA BAHASA DALAM LIRIK LAGU “LUGHĀT AL-‘ALAM” KARYA HUMOOD ALKHUDHER
Authors: Asyifah Nahdia
Published: August 2022

Lagu merupakan salah satu jenis karya sastra, lagu merupakan syair yang memiliki bait yang bermakna dan memiliki gaya bahasa tertentu yang dilukiskan oleh pengarang. Lirik lagu Lughāt Al-‘Alam menggambarkan tentang kasih sayang seorang ibu terhadap anaknya, Bahasa yang digunakan dalam lirik lagu ini mengandung makna kiasan, sehingga peneliti ingin menguraikan gaya bahasa yang terdapat dalam lirik lagu ini. Adapun tujuan dari penelitian ini adalah untuk mendeskripsikan ragam gaya bahasa yang terdapat dalam lirik lagu Lughāt Al-‘Alam karya Humood Alkhudher. Metode yang digunakan dalam analisis ini adalah metode kualitatif deskriptif. Metode kualitatif sederhana dilakukan melalui alur induktif atau proses dan peristiwa penjelas sehingga suatu generalisasi sebuah kesimpulan dari proses atau peristiwa tersebut dapat ditarik, sedangkan metode deskriptif merupakan prosedur dari adanya problem solving (pemecahan masalah) yang hendak diselidiki. Metode pengumpulan data yang digunakan adalah metode simak dengan teknik catat, guna untuk memperoleh data yang relevan, dan teknik catat merupakan teknik lanjutan. Hasil dari penelitian ini adalah pengarang menggunakan dua gaya Bahasa dalam lirik lagu, diantaranya adalah: 4 buah majas Hiperbola, 1 buah majas paradoks, dan 1 buah majas personifikasi.
Fenomena Perkembangan Musik Kontemporer di Arab
Authors: Salbiah Rahma , Ibnu Burdah
Published: August 2022

Fenomena yang terjadi sekarang sangat menyita perhatian banyak orang salah satunya di dunia seni musik, ada banyak perubahan yang terjadi dari waktu ke waktu. Tulisan ini bertujuan untuk menganalisis beberapa musik varian baru atau pembaharuan musik lama yang hadir di kalangan masyarakat Timur Tengah. Ada banyak faktor yang mempengaruhi masuknya musik varian baru ini, salah satunya adanya sistem modernisasi dari pihak pemerintah. Ada banyak tujuan yang dihadirkan akan pengadaan datangnya musik baru yang berbentuk konser, banyak spekulasi berdatangan baik positif maupun negatif karena munculnya budaya baru yang sebelumnya belum pernah hadir di kalangan masyarakat Timur Tengah. Dalam fenomena modernisasi di Timur Tengah ini terdapat suatu hal yang menarik, yaitu adanya faktor internal dan eksternal munculnya varian musik terbaru ini. Banyak konflik batin yang dirasakan oleh kaum muda akan kebijakan pemerintah, sehingga mereka menggunakan media sosial untuk ajang komunikasi membahas tatanan baru mengenai musik varian baru tersebut.