bluuebunny/crossref_metadata_2025 huggingface dataset:
Tackling Medication Non-Adherence in Portugal: The Boost of the ENABLE COST Action
Authors: Herdeiro Maria Teresa , Roque Fátima , Jácome Cristina , Maricoto Tiago , Teixeira Pedro Miguel , Moreira Paulo , Gregório João , Correia-de-Sousa Jaime
Published: July 2021

N/a.
Reply to: Biological Therapy in Patients with Rheumatoid Arthritis in a Tertiary Center in Portugal: A Cross-Sectional Study
Authors: Rodrigues Joana Ramos , Santos-Faria Daniela , Afonso Carmo , Tavares-Costa José
Published: July 2021

N/a.
Evaluación tomográfica del cóndilo y fosa mandibular en el tratamiento de las maloclusiones Clase II y Clase III. Revisión de Literatura.
Authors: Chávez–Sevillano Manuel Gustavo , Vidigal Junior Guaracilei Maciel , Quintão Cátia Cardoso Abdo
Published: July 2021

El tratamiento de varias maloclusiones esqueléticas en pacientes niños y jóvenes son realizadas aplicándose fuerzas ortopédicas, buscando alterar el crecimiento o abrir suturas en determinadas regiones anatómicas. El cóndilo (CO) y la fosa mandibular (FM) son regiones que han sido sometidas a fuerzas intensas esperando su remodelación ósea como parte del tratamiento. Debido a los clásicos registros bidimensionales utilizados para evaluar las alteraciones morfológicas anatómicas, muchos resultados han sido controversiales. Con el uso de las tomografías y las modernas técnicas de superposiciones tomográficas,  es posible identificar dichos cambios morfológicos de manera cuantitativa y cualitativa en las estructuras óseas. Se realizó una revisión de literatura integrada de las alteraciones morfológicas del CO y la FM  evaluados por medio de la tomografía computarizada (TC) y la tomografía computarizada de haz cónico (TCHC) en pacientes con maloclusiones  esqueléticas Clase II y Clase III que usaron aparatos con fuerzas ortopédicas. El objetivo fue  identificar en la literatura  los cambios morfológicos que ocurrieron en el CO y la FM después de aplicar los más aceptados protocolos de tratamientos de las respectivas maloclusiones. De esta manera nos permitirá eliminar factores intervinientes como distorsiones, superposiciones no deseadas de estructuras anatómicas y diversos errores de medición que tienen como característica los clásicos registros bidimensionales y que alteran la correcta  información.
Lesiones orales asociadas con VIH. Reporte de 3 casos clínicos
Authors: Aitken-Saavedra Juan , Dos Santos Bianca Camargo , Uchoa Vasconcellos Ana Carolina , Pineda Flores Dustan , Maturana-Ramírez Andrea
Published: July 2021

El síndrome de inmunodeficiencia adquirida (SIDA) es una manifestación clínica avanzada resultante de la infección por el virus de la inmunodeficiencia humana (VIH). Algunas lesiones orales pueden representar los primeros signos clínicos de infección por VIH o ser los marcadores de la progresión de la inmunodepresión causada por el virus. El objetivo de este estudio es presentar tres casos clínicos de pacientes en los que la sospecha de infección por VIH se basó en la presentación de manifestaciones intraorales. Los tres casos incluidos fueron los siguientes: mujer con placas semiadheridas de color blanco amarillentas que se desprendían al raspado y áreas eritematosas compatibles con candidiasis pseudomembranosa; hombre con lesión gingival eritematosa indolora, localizada en la zona del molar inferior, compatible con periodontitis ulceronecrotizante (PUN); y un hombre con lesiones vesiculo-ucerativas en paladar duro, compatible con presentación atípica de herpes simple intraoral recurrente. Es importante destacar el papel del cirujano dentista en el reconocimiento de tales lesiones bucales, que pueden ser las primeras manifestaciones en personas infectadas por el VIH.
Post-pruning storage and toasting of vine-shoots decrease fungicide residues
Authors: Cebrián-Tarancón Cristina , Sánchez-Gómez Rosario , Oliva José , Cámara Miguel Angel , Zalacain Amaya , Salinas M. Rosario
Published: July 2021

The potential use of vine-shoots as enological additives has been recently demonstrated. They can make a positive contribution to the sensorial profile of wines when they have been stored for 6 months after pruning, granulated, toasted under specific conditions and finally added to wines during winemaking. Since fungicide application is a common practice in vineyards, it is necessary to know the possible presence of such residues. In this study, a liquid chromatography-mass spectrometry analytical technique method for determination in vine-shoots of the main vineyard fungicides was developed, and their dissipation after post-pruning storage and toasting process was demonstrated. It was confirmed that the use of vine-shoots as enological additives will not pose a risk to the consumer, if good agricultural practices are used.
Combination of Using Pairwise Comparisons and Composite Reference Series: A New Approach in the Homogenization of Climatic Time Series
Authors: Domonkos Peter
Published: July 2021

The removal of non-climatic biases, so-called inhomogeneities, from long climatic records needs sophistically developed statistical methods. One principle is that usually the differences between a candidate series and its neighbour series are analysed instead of directly the candidate series, in order to neutralize the possible impacts of regionally common natural climate variation on the detection of inhomogeneities. In most homogenization methods, two main kinds of time series comparisons are applied, i.e. composite reference series or pairwise comparisons. In composite reference series the inhomogeneities of neighbour series are attenuated by averaging the individual series, and the accuracy of homogenization can be improved by the iterative improvement of composite reference series. By contrast, pairwise comparisons have the advantage that coincidental inhomogeneities affecting several station series in a similar way can be identified with higher certainty than with composite reference series. In addition, homogenization with pairwise comparisons tends to facilitate the most accurate regional trend estimations. A new time series comparison method is presented here, which combines the use of pairwise comparisons and composite reference series in a way that their advantages are unified. This time series comparison method is embedded into the ACMANT homogenization method, and tested in large, commonly available monthly temperature test datasets.
Calibration Algorithm for MIMU Sensors Group
Authors: Podoprosvetov Aleksei Valerievich , Aliseychik Anton Pavlovich , Orlov Igor Aleksandrovich , Rebrik Sergei Petrovich
Published: July 2021

Non-optical wearable sensors, such as magnetic and inertial measuring units (MIMU), are becoming popular in various fields: sports, medical, industrial - due to their ease of use and relative availability. We propose an algorithm for calibrating wearable sensors based on the rotation algebra. A system for visualizing human kinematics, which is reconstructed from MIMUs' data, is presented.
The Law in the Face of the COVID-19 Pandemic: Early Lessons from Uruguay
Authors: Norouzi Nima , Khanmohammadi Heshmat-ullah , Ataei Elham
Published: July 2021

The Corona crisis is one of the crises that has engulfed the world and Uruguay and has marked all human beings' death and life. This crisis has many legal, political, social, and economic dimensions and has and will have different consequences in this area. So far in the last two centuries, twelve major epidemics of infectious diseases and fifteen famines, and severe droughts have engulfed our world, but this crisis is "of a different kind." It has been less critical to cover the whole world. Infect millions of people, create new words in cultures, and announce major changes in international relations, politics, law, and the world and country economies. No geographical point is safe from this, and it has a serious impact on human relations. This paper is aimed to study the Uruguayan legal system in the post-Covid-19 world. In this paper, Constitutional, Financial, commercial, Labor, Public, and judicial law is discussed in the light of the Covid-19, and its impacts and strategies to mitigate those impacts are mentioned.
Measuring the Low-Income Earner on Housing Access in Urban Areas of Indonesia and Malaysia
Authors: Mohamad Mazliza , Yubaidi Ricco Survival , Hussein Safinaz Mohd , Ismail Rahmah , Isa Suzanna Mohamed , Abdul Aziz Saidatul Nadia
Published: July 2021

The ratio between the increased demand and limited land makes affordable housing in urban areas more difficult to accommodate. Indonesia and Malaysia, as populous countries, face problems related to housing access, especially for low-income earners in urban areas. The research was undertaken for two reasons. First, problems related to housing access for low-income earners in urban areas should be solved as soon as possible. Second, it is necessary to conduct a study in order to analyze and compare these two countries in measuring low-income earners on housing access in urban areas. To this end, the normative legal approach was applied. The materials used in this study were relevant statutes, rules, regulations, journals, articles, thesis, seminar papers, and electronic materials. The result showed that the fulfillment of housing access highly depends on the state’s developmental goals. It is also associated with principles of development that each country adheres to. The government is expected to provide accurate data in measuring low-income earners on housing access. Identification of beneficiaries by combining income classification and ability to housing access may facilitate policymakers with ease when taking affirmative measures. It is necessary to suggest initiative collaboration involving academicians, business sectors, community, and government (ABCG) in Indonesia and Malaysia to provide adequate housing in urban areas.
Manajemen Pembelajaran Jarak Jauh pada Mata Pelajaran PAI dan BP SMP di Kota Tegal
Authors: Kurniawati Indah , B.S Abdul Wachid
Published: July 2021

Abstract

Research on Distance Learning Management (PJJ) in the subject of Islamic Religious Education and Characteristics aims to identify distance learning management conducted on Islamic Education and BP SMP teachers in Tegal City. The distance learning management studied includes the Learning Management System (LMS) and PJJ Applications, the approaches and methods used, as well as the implications for competency attainment and the problems encountered. The Learning Management System and applications used are Google Classroom, WhatsApp, Google Form, Google Meeting, Zoom Cloud Meeting, and AGPAII Digital. The approach used is a scientific approach with the method of Problem Based Learning, Project Based Learning, Inquiry, and Discovery Learning. The implication of distance learning that is carried out is related to the achievement of students' competencies, including Attitude, Spiritual, Social, Knowledge and Skill Competencies. The training was carried out to overcome the problems faced, namely training on the use of LMS and PJJ applications, training on distance learning methods, and training on making ICT-based teaching materials. Effective communication with parents is needed in order to achieve competency attainment.

Abstrak
Penelitian Manajemen Pembelajaran Jarak Jauh (PJJ) pada mata pelajaran Pendidikan Agama Islam dan Budi Pekerti ini bertujuan untuk mengidentifikasi manajemen pembelajaran jarak jauh  yang dilakukan pada guru PAI dan BP SMP di Kota Tegal. Manajeman pembelajaran jarak jauh  yang diteliti meliputi Learning Management Sytem (LMS) dan Aplikasi PJJ, pendekatan dan metode yang digunakan, serta  implikasi terhadap ketercapaian kompetensi dan permasalahan yang ditemui. Learning Management Sytem dan aplikasi yang digunakan adalah Google Classroom, WhatsApp, Google Form, Google Meeting, Zoom Cloud Meeting, dan AGPAII Digital. Pendekatan yang digunakan adalah pendekatan saintifik dengan metode Problem Based Learning, Project Based Learning, Inquiry, dan Discovery Learning. Implikasi dari pembelajaran jarak jauh yang dilakukan berhubungan dengan ketercapaian kompetensi peserta didik, meliputi Kompetensi Sikap, yakni Spiritual dan Sosial, Pengetahuan, dan Ketrampilan. Pelatihan dilakukan untuk mengatasi permasalahan yang dihadapi, yaitu Pelatihan penggunaan LMS dan Aplikasi PJJ, Pelatihan metode pembelajaran jarak jauh, dan pelatihan pembuatan bahan ajar berbasis TIK. Komunikasi efektif dengan orang tua diperlukan guna mencapai ketercapaian kompetensi.
Fans y fanfictions, prácticas de lectura, apropiación y producción analizadas desde la estética de la recepción: el caso de Juego de Tronos y Canción de Hielo y Fuego
Authors: Espinoza Guanilo Antonio Hector
Published: July 2021

Esta investigación pretende analizar la recepción de una obra literaria y audiovisual dentro de una comunidad online de fans y, a partir de ello, la creación de literatura fan fiction por parte de los miembros de esta comunidad, así como su relación con el autor canónico. A través de la aplicación de encuestas y el análisis de contenidos, se pudo conocer sobre los fans de Juego de Tronos/ASOIAF, su producción de textos, y la forma en la que se relacionan en su comunidad. Gracias a esta información, y a la luz de los conceptos tomados de la Estética de la Recepción, se determinó de qué manera los fans vienen a ser una audiencia activa que produce nuevo contenido a partir de apropiarse de la obra original y resignificarla. Queda en evidencia la forma en que consumen la historia canónica y cómo interactúan con ella y sus autores.
Caracterización de las prácticas de innovación abierta en las pymes manufactureras en Bogotá
Authors: Gómez-Cristancho Maria Alejandra , Romero-Albarracin Laura Sofia , Palacios-Osma Jose Ignacio
Published: July 2021

En la actualidad, el principal objetivo de las organizaciones empresariales es aumentar la competitividad, por esta razón la innovación abierta se presenta como proceso facilitador en el desarrollo y el crecimiento de las empresas. Teniendo esto en cuenta, el objetivo del artículo es reconocer la disposición que existe por parte de las empresas a interactuar con otros actores del entorno, como, por ejemplo, la universidad, y así generar procesos colaborativos. Para esto se realizó un análisis de variables cualitativas a través de cuestionarios realizados a algunas empresas pymes —pequeñas y medianas empresas— del sector manufacturero de Bogotá y a docentes e investigadores de la Universidad Distrital. A partir de los resultados del estudio se formula un modelo de integración que caracteriza los factores claves para el desarrollo de procesos de innovación abierta entre los actores analizados. El modelo de integración propuesto busca resaltar los factores relevantes para los actores en estudio, con el fin de que, basados en este, sea posible definir claramente las metodologías, los acuerdos y las plataformas a utilizar entre las partes, garantizando la relevancia de los factores identificados y asegurando que no hay límite entre ellos en los procesos de innovación abierta. El análisis permite concluir que la implementación de este paradigma implica el establecimiento de relaciones de confianza, disposición de las partes, estructuración de un modelo de gestión de innovación y definición de los derechos de autor junto con acuerdos de cooperación claros y específicos.
Incentivos para a escrita e a leitura a partir da prática fotográfica
Authors: Savaris Michele , Passos Cíntia Barbosa , Cezar Claudia Zimmer de Cerqueira
Published: July 2021

O presente relato é resultado de um projeto de extensão que teve como objetivo levar a cabo algumas possibilidades no que diz respeito à relação entre diferentes campos, partindo de dois principais contextos: o da produção fotográfica e o da produção textual escrita. Para isso, propusemos a relação entre fotografia e texto escrito sob dois principais vieses: o primeiro levou em consideração o fato de que fotografia também é texto e, por isso, estabelece pontos de estreitamento com a escrita, inclusive no que se refere à correspondência das linguagens; o segundo buscou pensar a produção de gêneros textuais a partir da fotografia, agregando entre esses dois pontos o processo de criação. Para isso, o projeto foi dividido em três etapas. A primeira contemplou os aspectos teóricos sobre o campo fotográfico e o campo textual; a segunda abordou os processos de escrita a partir de fotografias e seu teor narrativo; a terceira contemplou a compreensão e a reflexão acerca da constituição dos gêneros textuais e o processo artístico a partir das fotografias. Para dar conta desses aspectos, estabeleceu-se um diálogo baseado em conceitos relacionados às disciplinas de Letras, Física e Artes. Os encontros, que eram semanais e aconteciam de forma on-line, contaram com a participação da comunidade interna e externa. Em cada encontro, discutia-se um tema e, ao final, era proposto um desafio, para praticar os conceitos estudados, envolvendo escrita textual e/ou fotografia. Os resultados eram compartilhados com o grande grupo e, em seguida, divulgados no Instagram.
Design of Portable Multicolor LED-Based Optical System for the Photobiomodulation Therapy on Wound Healing Process
Authors: Topaloglu Nermin , Balkaya Ufuk , Çevik Ziyşan Buse Yaralı
Published: July 2021

Photobiomodulation is a practical and non-invasive treatment that triggers cell proliferation, cell differentiation, wound healing, new tissue formation, inflammation and pain reduction with low-level light therapy. Light-emitting diodes (LEDs) are energy-saving, affordable and safe alternatives to laser devices which are recently preferred in photobiomodulation. Although the wavelengths between 600-700 nm are most preferred ones, there is a lack of practical optical systems which study this mechanism in vitro with different wavelengths simultaneously. In this study, a portable and remotely controlled multicolor LED-based system was designed and tested on the wound healing process of human keratinocytes by irradiating the cells homogenously with 3 different wavelengths (460-475 nm as blue, 515-535 nm as green, and 585-595 nm as orange) on different experimental groups at the same time. Its proliferative and wound healing effect was evaluated with cell viability (MTT) analysis and cell migration (scratch) assay, respectively. It was observed that orange-LEDs were designated as the most triggering wavelength in terms of cell proliferation. Also, it was revealed with this device that different wavelengths can reach the intended accelerated wound healing process, so this optical system will be an advantageous design for future practical photobiomodulation studies in vitro.
A Method for Fault Detection in Wireless Sensor Network Based on Pearson's Correlation Coefficient and Support Vector Machine Classification
Authors: Biswas Priyajit , Samanta Tuhina
Published: July 2021

Sensor nodes are tiny low-cost devices, prone to various faults. So, it is imperative to detect those faults. This paper presents a sensor measurement fault detection algorithm based on Pearson's correlation coefficient and the Support Vector Machine(SVM) algorithm. As environmental phenomena are spatially and temporally correlated but faults are somewhat uncorrelated, Pearson's correlation coefficient is used to measure correlation. Then we used SVM to classify faulty readings from normal reading. After classification, faulty readings are discarded. We used network simulator NS-2.35 and Matlab for evaluation of our proposed method. We evaluated our fault detection algorithm using performance metrics, namely, Accuracy, Precision, Sensitivity, Specificity, Recall, F1 Score, Geometric Mean(G_mean), Receiver Operating Characteristics (ROC), and Area Under Curve(AUC).
A Novel Association of Hbq India Trait with Sickle Cell Anemia: A New Insight in Hemoglobinopathies
Authors: Gupta Rakesh Kumar , Verma Kartavya Kumar , Singh Gurmeet
Published: July 2021

HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the heterozygous form or co-inherited with β-thalassemia trait. Herein, we are reporting the third case of novel association of HbQ India with HbS trait hemoglobinopathy in a 30-years-old young male presented with chief complaints of yellowish discoloration of sclera since 5-years with raised serum bilirubin levels along with pedigree analysis of the family.
Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase
Authors: Haraguchi Tokuko , Koujin Takako , Shindo Tomoko , Bilir Şükriye , Osakada Hiroko , Nishimura Kohei , Hirano Yasuhiro , Asakawa Haruhiko , Mori Chie , Kobayashi Shouhei , Okada Yasushi , Chikashige Yuji , Fukagawa Tatsuo , Shibata Shinsuke , Hiraoka Yasushi
Published: July 2021

DNA transfection is an important technology in the life sciences, wherein nuclear entry of DNA is necessary to achieve expression of the exogenous DNA. Non-viral vectors and their transfection reagents are useful as safe tools for transfection. However, they have no effects for transfection of non-proliferating cells, the reason for which remains unknown. This study aimed to elucidate the mechanism by which transfected DNA enters the nucleus for gene expression. To monitor the intracellular behavior of transfected DNA, we introduced a plasmid bearing lacO repeats and RFP-coding sequences into cells expressing GFP-LacI and observed plasmid behavior and RFP expression. RFP expression appeared only after mitosis. Electron microscopy showed that plasmids were wrapped with nuclear envelope (NE)-like membranes or associated with chromosomes at telophase. Depletion of BAF, which is involved in NE reformation, delayed plasmid RFP expression. These results suggest that transfected DNA is incorporated into the nucleus via NE reformation at telophase.
Truncation Effect on Estimation of Transport Parameters for Slug-injection Tracer Tests
Authors: Kurasawa Tomoki , Takahashi Yoshitaro , Suzuki Mariko , Inoue Kazuya
Published: July 2021

For slug-injection tracer tests, tracer concentrations below the detection limit of the measurement instrument can cause truncation of the observed data. This study investigated the truncation effect on the estimation error of parameters based on analytical solutions and the results of a laboratory-scale experiment. Spatial moment analysis was performed to estimate the measured total mass and transport parameters, including the pore velocity and the longitudinal and transverse dispersivities. Increasing the travel distance and detection limit caused the measured mass and dispersivities to be underestimated regardless of the dimensionality because hydrodynamic dispersion occurs with increasing travel distance, which smoothens the concentration front. The one- and two-dimensional cases showed that the truncation effect on the measured mass and longitudinal dispersivity depended on dimensionality. In contrast, the pore velocity showed no such dependence; the center of mass did not change as the unmeasured portion due to truncation was increased because the plume, which exhibited a Gaussian distribution, was truncated symmetrically. In the experiment, the measured mass and dispersivities likewise depended on the travel distance and detection limit, but there were large differences in the detection limit at which the dimensionless parameter reached a value of zero between the experimental results and analytical solution. This is because the initial plume in the experiment was of a finite size. Thus, experimental design factors such as the scale, device, and dimensionality should be considered to minimize the estimation error of transport parameters, excluding the pore velocity.
A Sector-Based Approach To Hybrid TDMA And NOMA With Digital Beamforming For Fairness Improvement In Wireless Powered Communication Networks
Authors: Yoon Deukong , Dahouda Mwamba Kasongo , Maeng Juhyun , Joe Inwhee
Published: July 2021

In recent years, Wireless Powered Communication Network (WPCN) has been a promising technology that can be applied to existing low-power sensor networks and the Internet of Things (IoT). Sensor nodes or IoT devices are usually battery-powered. It is possible to use naturally collectable energy such as solar and wind without using a battery, but this is not a stable supply of energy. Therefore, the idea of operating a sensor network by separately setting a base station that continuously supplies power with radio waves has been presented. ThMris paper proposes an approach for how to combine Non-Orthogonal Multiple Access (NOMA) and Time-Division Multiple Access (TDMA) among various multiple access protocols applicable to wireless powered communication networks. There are some problems using TDMA alone. If a time slot is allocated so that the sum-throughput is maximized, the fairness of nodes is not guaranteed. To cope with these shortcomings, NOMA, which is known as a method to improve fairness, is mixed. Our approach is that cells are divided into sectors so that TDMA is used among sectors while NOMA is used within sectors. In addition, optimization of the sector by sector time allocation for maximum sum-throughput can lead to residual energy in certain sectors. Therefore, a directional digital beamforming adapted to the transmission for each sector is used for efficient energy transmission.
Unlike the previous user clustering, we attempt to generalize the number of nodes for NOMA from the fixed two nodes to any nodes by introducing the sector-based system model. The simulation results show that there is a trade-off between the sum-throughput and fairness because the sum-throughput increases but the fairness decreases as the number of sectors increases. As a result, we can suggest that a balanced range lies in between three and six sectors to satisfy both the sum-throughput and fairness at the same time. Finally, it is proven that our hybrid approach improves fairness significantly with the increasing number of nodes, as compared to the original TDMA only.
Italian Consensus Statement for Promoting Psycho-Social Wellbeing and Engagement in the Care of Inflammatory Bowel Disease Patients
Authors: Graffigna Guendalina , Bosio Caterina , Pagnini Francesco , Volpato Eleonora , Previtali Enrica , Leone Salvatore , D’Amico Ferdinando , Armuzzi Alessandro , Danese Silvio
Published: July 2021

Inflammatory bowel diseases (IBD) are remitting and relapsing diseases that mainly interest the gastrointestinal tract. This is associated with a condition of psycho-social discomfort that prevents the affected person from living normally and deeply compromises the quality of life in terms of personal, work, and interpersonal well-being. Management of IBD patients should include not only clinical but also psychosocial aspects not only clinical but also psychosocial aspects in order to improve patients' wellbeing and quality of life. The promotion of patient engagement is an effective strategy to achieve a better patient's quality of life. Although the undoubted role of patient involvement in the decision making process, to date there is no standardized approach to promote the engagement between physicians and patients and little attention is paid to social and psychological needs of subjects with IBD.To fill this gap, a consensus conference has been organized involving both gastroenterologists, healthcare professionals expert in IBD care and IBD patients in order to define the psychosocial needs of IBD patients and to promote their engagement in daily clinical practice.
Promoting Self-Management Behaviors In Adolescents With Type 1 Diabetes, Using Digital Storytelling: A Randomized Controlled Trial
Authors: Zarifsanaiey Nahid , Shirazi Masoomeh Otrodi , Mehrabi Manoosh , Bagheri Zahra
Published: July 2021

Background: This study aimed to assess the effects of digital storytelling on the self-management behavior of adolescents with type 1 diabetes (TID). Methods: In this randomized controlled clinical trial, 60 adolescents with TID were randomly allocated into two parallel groups: intervention (training with digital storytelling method, n=33) or control (training with a conventional method, n=33). The primary outcome was the assessment of the Self-Management behavior of adolescents with TID (SMOD-A), at baseline and three months after the intervention.Results: The results revealed that digital storytelling can lead to significant improvement in self-management behaviors amongst the adolescents with TID (P=0.005), while in the control group no significant changes were observed (P>0.05). The results also showed that the level of collaboration with parent’s dimension scores had a significant reverse relationship with the adolescent age after digital storytelling (p = 0.048). With respect to HbA1c levels, significant changes were not observed in any of the groups (P>0.05).Conclusions: Digital storytelling is practicable and a potentially beneficial training modality for adolescents with TID.Trial registration: This trial was respectively registered.ClinicalTrials.gov Identifier: IRCT20191220045828N1. Date of registration: Oct 29. 2020(https://clinicaltrials.gov/ct2/show/NCT04608058?term=zarifsanaiey&draw=2&rank=1)
Survival of Patients with Floor of Mouth Squamous Cell Carcinoma Treated with Surgical Resection and Reconstruction
Authors: Maharaj Shivesh , Thokan Nishat
Published: July 2021

Objective. To identify predictors of survival in patients with floor of mouth SCC in order to improve patient selection for resource intensive resection and reconstruction procedures.Study design and setting. A retrospective record review of patients who underwent resection and reconstruction for floor of mouth SCC at Charlotte Maxeke Johannesburg Academic Hospital. Methods. Patient data were collected and analyzed with respect to age, sex, race, tobacco usage, alcohol usage, tumour stage and postoperative chemo-radiation. One- and five-year recurrence and survival rates were also evaluated.Conclusion. The use of alcohol as well as disease stage appear to be significant variables in the risk of recurrence and five-year survival of patients.
Drain Current Modeling of Tunnel FET using Simpson’s Rule
Authors: V Arun A , K Minu K , S Sreelakshmi P , Jacob Jobymol
Published: July 2021

Tunnel Field Effect Transistor can be introduced as an emerging alternate to MOSFET which is energy efficient and can be used in low power applications. Due to the challenge involved in integration of band to band tunneling generation rate, the existing drain current models are inaccurate. A compact analytical model for simple tunnel FET and pnpn tunnel FET is proposed which is highly accurate. The numerical integration of tunneling generation rate in the tunneling region is performed using Simpson’s rule. Integration is done using both Simpson’s 1/3 rule and 3/8 rule and the models are validated against numerical device simulations. The models are compared with existing models and it is observed that the proposed models show excellent agreement with device simulations in the entire region of operation with Simpson’s 3/8 rule exhibiting the maximum accuracy.
Detection of illicit cryptomining using network metadata
Authors: Russo Michele , Šrndić Nedim , Laskov Pavel
Published: July 2021

Illicit cryptocurrency mining has become one of the prevalent methods for monetization of computer security incidents. In this attack, victims' computing resources are abused to mine cryptocurrency for the benefit of attackers. The most popular illicitly mined digital coin is Monero as it provides strong anonymity and is efficiently mined on CPUs. Illicit mining crucially relies on communication between compromised systems and remote mining pools using the de facto standard protocol Stratum. While prior research primarily focused on endpoint-based detection of in-browser mining, in this paper we address network-based detection of cryptomining malware in general. We propose XMR-Ray, a machine learning detector using novel features based on reconstructing the Stratum protocol from raw NetFlow records. Our detector is trained offline using only mining traffic and does not require privacy-sensitive normal network traffic, which facilitates its adoption and integration. In our experiments, XMR-Ray attained 98.94% detection rate at 0.05% false alarm rate, outperforming the closest competitor. Our evaluation furthermore demonstrates that it reliably detects previously unseen mining pools, is robust against common obfuscation techniques such as encryption and proxies, and is applicable to mining in the browser or by compiled binaries. Finally, by deploying our detector in a large university network, we show its effectiveness in protecting real-world systems.
Indigenous Groups and Influenza: Protocol For A Systematic Review and Meta-Analysis
Authors: Alves Daniele Evelin , Røgeberg Ole , Mamelund Svenn-Erik
Published: July 2021

Background: Several studies have documented that indigenous groups have been disproportionally hit by previous pandemics, with some exceptions. The objective of this review and meta-analysis is to provide a comprehensive historical overview of pre-COVID impact of influenza on indigenous groups by combining data from the last five influenza pandemics and seasonal influenza up to date. Methods/Principle Findings: The review will include peer-reviewed original studies published in English, Spanish, Portuguese, Swedish, Danish and Norwegian. Records will be identified through systematic literature search in eight databases: Embase, Medline, Cinahl, Web of Science, Academic Search Ultimate, SocIndex, ASSIA and Google Scholar. Results will be summarized narratively and using meta-analytic strategies. Discussion: To our knowledge, there is no systematic review combining historical data on the impact of both seasonal and pandemic influenza on indigenous populations. By summarizing results across indigenous groups in different countries and historical periods, we aim to provide information on how strong the risk for influenza is among indigenous people, and how consistent this risk is across groups, areas and time. Systematic review registration: PROSPERO registration number: CRD42021246391
Sex and Age Difference in Risk Factor Distribution, Trend, and Long-Term Outcome of Patients Undergoing Isolated Coronary Artery Bypass Graft Surgery
Authors: Sattartabar Babak , Ajam Ali , Pashang Mina , Jalali Arash , Sadeghian Saeed , Mortazavi Hamideh , Mansourian Soheil , Bagheri Jamshid , Karimi Abbas-Ali , Hosseini Kaveh
Published: July 2021

Background

Preoperative coronary artery disease risk factors (CADRFs) distribution and pattern may also have an important role in determining major adverse cardiovascular (MACEs). In this study, we aimed to evaluate the CADRFs distribution and trend over 10 years and also the long-term outcome of CABG in different age-sex categories.
Method:

In this registry-based serial cross-sectional study, we enrolled 24328 patients who underwent isolated CABG and evaluated the prevalence of CADRFs according to sex and age. We also used the Kaplan-Meyer method for long-term outcomes in different age-sex categories’ survival plots.
Results

In general, DLP (56.00%), HTN (53.10%), DM (38.40%), and positive family history (38.30%) were the most frequent risk factors in all patients. Prevalence of HTN, DLP, DM, Obesity and positive family history were all higher in women, all statistically significant. The median follow-up duration was 78.1 months (76.31 to 79.87 months). Men under 50 had the best survival (93.6%) and least incident of MACE (20.8%). Worst survival observed in female patients older than 55 (83.4%) who also had the highest incident of MACE (30.6%)
Conclusion

Although DLP is still the most frequent CADRF among the CABG population, the level of LDL and TG is decreasing. Female patients have more risk factors and worse long-term outcomes (in terms of mortality and MACE incidence) Therefore, health care providers and legislators must pay greater attention to female population CADRFs and ways to prevent them at different levels.
Evaluation of Anti-Cancer Effects of Lycopene extracted from Pink Guava Psidium guajava L. and its Combination with Apigenin or Resveratrol
Authors: PRIAM FABIENNE , Marcelin Odile , Marcus Roselyne , Wijkhuisen Anne , Smith-Ravin Emilie Juliette
Published: July 2021

Background

Active biomolecules extracted from plant biodiversity appear to offer an alternative to the frequently toxic chemotherapy methods used to treat cancer. The micronutrients obtained from certain fruits, including pink guava Psidium guajava L., appear to have this property. We therefore focused on three biomolecules of interest: lycopene and apigenin, the main components in pink guava, and resveratrol, a reference biomolecule with recognized beneficial effects. Our aim was to assess and compare the activities of these micronutrients, first separately and then in combination, on LNCaP cells (prostate cancer) and UACC cells (melanoma).
Methods

MTT assays and confocal microscopy using anti-PCNA and anti-5-α-reductase antibodies enabled us to establish a ranking for these micronutrients for the first time, when they were studied separately to begin with, in terms of their anti-proliferative action.
Results

Apigenin was found to be the most active biomolecule in this respect, followed by lycopene and then resveratrol. In a subsequent study of the combined actions of these molecules, specifically “lycopene-apigenin” and “lycopene-resveratrol”, we found that the “lycopene-apigenin” combination has a stronger anti-cancer activity than the biomolecules used separately, and it is also superior to the “lycopene-resveratrol” combination.
Conclusions

Our study demonstrated the synergistic modes of action of lycopene and apigenin in the guava fruit and the importance of the combination of these two micronutrients in pink guava in order to obtain a high anti-cancer activity.
Immune-Related Long Non-Coding RNA Constructs a Prognostic Signature of Ovarian Cancer
Authors: Sun Xiaoyu , Li Shan , Lv Xuemei , Yan Yuanyuan , Wei Minjie , Wang Xiaobin , He Miao
Published: July 2021

Background
Since ovarian cancer leads to the poor prognosis in women all over the world, we aim to construct an immune-related lncRNAs signature to improve the survival of ovarian cancer patients.
Methods
Normal and cancer patient samples and corresponding clinical data of ovarian were obtained from Genome Tissue Expression (GTEx) portal and The Cancer Genome Atlas (TCGA) database. The predictive signature was constructed by the lasso penalty Cox proportional hazard regression model. The division of different risk groups was accounting for the optimal critical value of the time-dependent ROC curve. Finally, we validated and evaluated the application of this prognostic signature based on the clinical factors, chemo-sensitivity and immune status of different risk groups.
Results
The signature was established from 145 DEirlncRNAs and can be showed as an independent prognostic risk factor with accurate prediction on overall survival in ovarian cancer patients. Further analysis on the application of the prognostic signature showed that patients with low-risk had a better sensitivity to chemotherapy and a higher immunogenicity.
Conclusion
We constructed and verified an effective signature based on DEirlncRNA pairs, which can predict the prognosis, drug sensitivity and immune status of ovarian cancer patients and promote the prognostic estimation and individualized treatment.
Design of Polyhydroxyalkanoate (PHA) Microbeads with Tunable Functional Properties and High Biodegradability in Seawater
Authors: Volant Chloé , Balnois Eric , Vignaud Guillaume , Magueresse Anthony , Bruzaud Stephane
Published: July 2021

Commercial poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) were used to prepare microbeads, with diameter ranging from 50 to 100 µm, by an emulsion-evaporation process. The properties of the beads reveal that the elaboration process enables the formation of spherical particles, that the crystallinity of the former polymer is not altered during the process and that the surface roughness of the particles can be tuned by changing the nature of the lateral chain in the PHA structure, in good correlation with its crystalline behavior. The mechanical properties of the different PHA beads are also found to be intimely linked with the crystalline content of the beads, with modulus varying between 1 to 7 GPa. All these properties are also governing the degradation behavior of these materials, as tested under marine environment. With a rapid degradation, similar to cellulose, and a degradation rate correlated with the crystalline content, these results emphasize the interest in developing PHA materials with tunable functions and degradation properties.
Cooperative Ankle-Exoskeleton Control Can Reduce Effort to Recover Balance After Unexpected Disturbances During Walking
Authors: Bayón Cristina , Keemink Arvid Q.L. , Mierlo Michelle van , Rampeltshammer Wolfgang , Kooij Herman van der , Asseldonk Edwin H.F. van
Published: July 2021

BackgroundIn the last two decades, lower-limb exoskeletons have been developed to assist human standing and locomotion. One of the ongoing challenges is the cooperation between the exoskeleton balance support and the wearer control. Here we present a cooperative ankle-exoskeleton control strategy to assist in balance recovery after unexpected disturbances during walking, which is inspired on human balance responses.MethodsWe evaluated the novel controller in ten able-bodied participants wearing the ankle modules of the Symbitron exoskeleton. During walking, participants received unexpected forward pushes with different timing and magnitude at the pelvis level, while being supported or not by the robotic assistance provided by the controller.ResultsThe results show that the controller was able to reduce participants’ effort while keeping similar ability to counteract and withstand the balance disturbances (average reduction of 10.09% in soleus activity, 5.20% in gastrocnemius medialis activity and 6.67% in gastrocnemius lateralis activity for the stance leg).ConclusionThe proposed controller was able to cooperate with the able-bodied participants in counteracting perturbations, contributing to the state-of-the-art of bio-inspired cooperative ankle exoskeleton controllers for supporting dynamic balance. In the future, this control strategy may be used in exoskeletons to support and improve balance control in users with motor disabilities.
Time to Patients’ Access to New Medicines in Greece: Evaluation of Health Technology Assessment (HTA) Process from July 2018 until January 2021.
Authors: Kourlaba Georgia , Beletsi Alexandra
Published: July 2021

Background: To present the outcome of the Health Technology Assessment (HTA) process in Greece from its onset back in July 2018 till January 2021 and to quantify the median time from marketing authorization (MA) to listing especially for new medicines. Methods: All products included in the reimbursement positive list from July 2018 to January 2021, were identified through the relevant Ministerial Decisions (MDs) posted on the website of the Ministry of Health (MoH) and the Positive Reimbursement Lists issued this period. The following information were collected for these medicines: date that MDs and Positive Reimbursement lists were issued, the legal basis of the initial MA, the MA date, the date of price registration, and the type of the HTA application. The time from MA to listing was calculated. Results: During the study period, 38 MDs were issued from which 35 (92%) were positive and resulted in the inclusion of 318 medicines and 3 (8%) were negatives that excluded 6 medicines. Focusing on new medicines, the median time from MA to listing was found to be 30 months with an interquartile range of 22 to 39 months. This time was statistically significantly shortened for FDC [19.3 (13-35) months], compared to biosimilars [26 (22-35) months, p=0.09] and on patent [38.5 (29-44) months, p=0.008]. For new generics, the corresponding median time was 22 (IQR: 12.5-31) months, statistically significantly lower than that of new medicines (p=0.028). Focusing on the four most common therapeutics areas, the median (IQR) time from MA to listing for new medicines was 28.3 (24.9–32.9) months and 34.9 (21.9-41.1) months, for oncologic and immunosuppressants (p=0.136), respectively, while on the field of cardiovascular and CNS there was no reimbursement of new active substances during the study period. Conclusions: This study showed that it takes a long time for Greek patients to get access to newly registered medicines. Given that the delay in access might result in potential loss of many life years, actions should be taken by policy makers to speed up patients access to new and innovative medicines.
Effectiveness of Double-hit Model (Post-weaning Social Isolation and NMDA Receptor Antagonist) in the Development of Schizophrenic Like Symptoms on Rodents: A Protocol for a Systematic Review.
Authors: Shangase Khanyiso Bright , Magwai Thabo , Oginga Fredrick Otieno , Xulu Khethelo Richman , Mpofana Thabisile
Published: July 2021

BackgroundSchizophrenia is a heterogeneous neuropsychiatric disorder, categorized by positive, negative, and cognitive symptoms. In trying to improve diagnosis and treatment of schizophrenia researchers have turn to “dual hit” models of schizophrenia that are able to reproduce all symptoms of the disorder. The main objective of this protocol is to present a transparent process on how we plan to review the existing international literature on effectiveness of “dual hit” models used to induce schizophrenia on rodents. MethodsLiterature search strategies will be developed using medical search headings (MeSH). The MEDLINE (PubMed), EMBASE, and Google Scholar databases will be used to search for published studies electronically. We will search for studies involving inducing schizophrenic symptoms using “dual hit” rodent model (post-weaning social isolation and NMDA receptor antagonist). Studies will be screened by titles, abstracts, keywords, and synonyms followed by identifying the full-text articles. All studies that will pass the quality assessment will be included. Data will be extracted by two authors independently and in duplicate, from each eligible study in ensuring that there is consistency between reviews. If the design and comparator are sufficiently homogenous for all studies, meta-analysis will be conducted using a random-effect model.DiscussionThe results of this review will contribute in the development of new “dual hit” models that will be able to characterize schizophrenia symptoms better. It will also shed light to researchers on new developments that need to be made in improving animal models of schizophrenia.Systematic reviews registrationPROSPERO CRD42021247585