bluuebunny/crossref_metadata_2025 huggingface dataset:
Axially Chiral Biaryl Diols Catalyze Highly Enantioselective Hetero‐Diels—Alder Reactions Through Hydrogen Bonding.
Authors: Unni Aditya K. , Takenaka Norito , Yamamoto Hisashi , Rawal Viresh H.
Published: May 2005

For Abstract see ChemInform Abstract in Full Text.
Mild and Efficient Silylcyanation of Aldehydes Catalyzed by Zirconium Complex.
Authors: Kim Sung Soo , Lee Jun Tae , Song Dae Ho , Lee Ik‐Mo , Park Sun Young
Published: May 2005

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Ketone Synthesis by Intramolecular Acylation or Organorhodium(I) with Ester.
Authors: Miura Tomoya , Sasaki Taisuke , Nakazawa Hiroki , Murakami Masahiro
Published: May 2005

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Synthesis of Some New Pyridazine, 1,2,4‐Triazine and 1,3,4‐Thiadiazole Derivatives.
Authors: Farag Ahmad M. , Dawood Kamal M. , Abdel‐Aziz Hatem A.
Published: May 2005

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Estrogen Receptor Ligands. Part 11. Synthesis and Activity of Isochromans and Isothiochromans.
Authors: Liu Jian , et al. et al.
Published: May 2005

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Biphasic Aerobic Oxidation of Alcohols Catalyzed by Poly(ethylene glycol)‐Stabilized Palladium Nanoparticles in Supercritical Carbon Dioxide.
Authors: Hou Zhenshan , Theyssen Nils , Brinkmann Axel , Leitner Walter
Published: May 2005

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Synthesis of Dendritic Catalysts and Application in Asymmetric Transfer Hydrogenation.
Authors: Chen Ying‐Chun , Wu Tong‐Fei , Jiang Lin , Deng Jin‐Gen , Liu Hui , Zhu Jin , Jiang Yao‐Zhong
Published: May 2005

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Remarkable Selectivity in Addition of Alcohols to Epoxydienes of 5,7‐Bicyclic and 5,7,6‐Tricyclic Systems.
Authors: Boyer Francois‐Didier , Hanna Issam
Published: May 2005

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Asymmetric Epoxidation of cis‐Alkenes Mediated by Iminium Salts: Highly Enantioselective Synthesis of Levcromakalim.
Authors: Page Philip C. Bulman , Buckley Benjamin R. , Heaney Harry , Blacker A. John
Published: May 2005

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Bromination of Carbon—Carbon Double Bonds Involving Oxidation of NaBr in an Ionic Liquid.
Authors: Ying Taokei , Bao Weiliang , Zhang Yongmin
Published: May 2005

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Highly Reactive, General, and Long‐Lived Catalysts for Coupling Heteroaryl and Aryl Chlorides with Primary Nitrogen Nucleophiles.
Authors: Shen Qilong , Shekhar Shashank , Stambuli James P. , Hartwig John F.
Published: May 2005

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Synthesis and Applications of Chiral Organoboranes Generated from Sulfonium Ylides.
Authors: Aggarwal Varinder K. , Fang Guang Yu , Schmidt Andreas T.
Published: May 2005

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Tandem Intramolecular Carbolithiation—Transmetalation: From Lithium to Copper or Boron Chemistry.
Authors: Ortiz Rosa , Yus Miguel
Published: May 2005

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Stille Reactions Catalytic in Tin: A “Sn—F” Route for Intermolecular and Intramolecular Couplings.
Authors: Gallagher William P. , Maleczka Robert E. Jr.
Published: May 2005

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Equilibrium Control in Enyne Metathesis: Crossover Studies and the Kinetic Reactivity of (E,Z)‐1,3‐Disubstituted‐1,3‐dienes.
Authors: Geissert Anthony J. , Diver Steven T.
Published: May 2005

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Spiro‐annulation of Barbituric Acid Derivatives and Its Analogues by Ring‐Closing Metathesis Reaction.
Authors: Kotha Sambasivarao , Deb Ashoke Chandra , Kumar Ramanatham Vinod
Published: May 2005

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P2O5/SiO2 as a Mild and Efficient Reagent for Acylation of Alcohols, Phenols and Amines under Solvent‐Free Conditions.
Authors: Eshghi Hossein , Shafieyoon Parvaneh
Published: May 2005

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Copper‐Catalyzed Allylic Hydroxyamination and Amination of Alkenes with Boc‐Hydroxylamine.
Authors: Kalita Biswajit , Nicholas Kenneth M.
Published: May 2005

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Two New Irreversible Inhibitors of Dihydrodipicolinate Synthase: Diethyl (E,E)‐4‐Oxo‐2,5‐heptadienedioate and Diethyl (E)‐4‐Oxo‐2‐heptenedioate.
Authors: Turner Jennifer J. , Healy Jackie P. , Dobson Renwick C. J. , Gerrard Juliet A. , Hutton Craig A.
Published: May 2005

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Synthesis and Reactions of N‐o‐Anisylsulfonylmethyl‐ and N‐o‐sec‐Butoxysulfonylmethylcarbodiimides with Aldehydes.
Authors: Tandon Vishnu K. , Singh Kunwar A. , Rai Sanjay , van Leusen Albert M.
Published: May 2005

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Synthesis of Azulen‐3‐ylheterocyclic Compounds Using 2‐(3‐Methoxycarbonylazulen‐1‐yl)ethynyltriphenylphosphonium Bromide.
Authors: Morita Noboru , Moriyama Shiro , Shoji Taku , Nakashima Masashi , Watanabe Masataka , Kikuchi Shigeru , Ito Shunji , Fujimori Kunihide
Published: May 2005

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Metal Carbene Promoted Sequential Transformations for the Enantioselective Synthesis of Highly Functionalized Cycloheptadienes.
Authors: Deng Liang , Giessert Anthony J. , Gerlitz Oksana O. , Dai Xing , Diver Steven T. , Davies Huw M. L.
Published: May 2005

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A Novel and Efficient Synthesis of Bicyclo[2.2.2]octenones and Sigmatropic Shifts in Ground and Excited States: Stereoselective Route to cis‐Decalins and Diquinane Frameworks.
Authors: Singh Vishwakarma , Iyer Sridhar R. , Mobin Shaikh M.
Published: May 2005

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Reductive Monoalkylation of Aromatic and Aliphatic Nitro Compounds and the Corresponding Amines with Nitriles.
Authors: Nacario Ruel , Kotakonda Shailaja , Fouchard David M. D. , Tillekeratne L. M. Viranga , Hudson Richard A.
Published: May 2005

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A Simple One‐Pot Procedure for the Iminium Salt Formation: An Efficient Route to β‐Arylethylamines.
Authors: Ku Yi‐Yin , Grieme Tim , Pu Yu‐Ming , Bhatia Ashok V. , King Steve A.
Published: May 2005

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Synthesis and Biological Evaluation of New Clofibrate Analogues as Potential PPARα Agonists.
Authors: Perrone Maria Grazia , Santandrea Ernesto , Dell'Uomo Natalina , Giannessi Fabio , Milazzo Ferdinando Maria , Sciarroni Anna Floriana , Scilimati Antonio , Tortorella Vincenzo
Published: May 2005

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Chemoselective Reduction of Ketones: Trifluoromethylketones versus Methylketones.
Authors: Sasaki Shigeru , Yamauchi Takayasu , Kubo Hajime , Kanai Masatomi , Ishii Akihiro , Higashiyama Kimio
Published: May 2005

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Synthesis of a Bulky and Electron‐Rich Derivative of SEGPhos and Its Application in Ru‐Catalyzed Enantioselective Hydrogenation of β‐Ketoesters.
Authors: Wan Xiaobing , Sun Yanhui , Luo Yunfei , Li Dao , Zhang Zhaoguo
Published: May 2005

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Stereoselective Dihydroxylation Reactions of γ‐Amino‐α,β‐unsaturated Esters via Their Aryl Ketimine Derivatives.
Authors: Oh Joon Seok , Jeon Jongho , Park Do Yeon , Kim Young Gyu
Published: May 2005

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Synthesis of Enantiopure Sulfinimines (Thiooxime S‐Oxides) Catalyzed by Yb(OTf)3 from p‐Toluenesulfinamide and Aldehydes in Mild Reaction Conditions.
Authors: Jiang Zhi‐Yong , Chan W. H. , Lee A. W. M.
Published: May 2005

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Triaryl Bis‐sulfones as a New Class of Cannabinoid CB2 Receptor Inhibitors: Identification of a Lead and Initial SAR Studies.
Authors: Lavey Brian J. , Kozlowski Joseph A. , Hipkin R. William , Gonsiorek Waldemar , Lundell Daniel J. , Piwinski John J. , Narula Satwant , Lunn Charles A.
Published: May 2005

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A Task‐Specific Ionic Liquid [bmim]SCN for the Conversion of Alkyl Halides to Alkyl Thiocyanates at Room Temperature.
Authors: Kamal Ahmed , Chouhan Gagan
Published: May 2005

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A Palladium Chugaev Carbene Complex as a Modular, Air‐Stable Catalyst for Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Moncada Adriana I. , Khan Masood A. , Slaughter LeGrande M.
Published: May 2005

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Thiazolylalanine‐Derived Catalysts for Enantioselective Intermolecular Aldehyde—Imine Cross‐Couplings.
Authors: Mennen Steven M. , Gipson John D. , Kim Yoona R. , Miller Scott J.
Published: May 2005

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Highly Enantioselective Phenyl Transfer to Aryl Aldehydes Catalyzed by Easily Accessible Chiral Tertiary Aminonaphthol.
Authors: Ji Jian‐Xin , Wu Jing , Au‐Yeung Terry T.‐L. , Yip Chiu‐Wing , Haynes Richard K. , Chan Albert S. C.
Published: May 2005

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An Efficient and Practical Synthesis of β‐Hydroxyl Ketones Catalyzed by Trisodium Phosphate under Ultrasound.
Authors: Li Ji‐Tai , Xu Wen‐Zhi , Chao Xi , Li Tong‐Shuang
Published: May 2005

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Highly Enantioselective Phenylacetylene Addition to Aromatic Ketones Catalyzed by Cinchona Alkaloid—Aluminum Complexes.
Authors: Liu Lei , Wang Rui , Kang Yong‐Feng , Chen Chao , Xu Zhao‐Qing , Zhou Yi‐Feng , Ni Ming , Cai Hua‐Qing , Gong Mao‐Zhen
Published: May 2005

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PtBr2‐Catalyzed Consecutive Enyne Metathesis—Aromatization of 1‐(1‐Methoxy‐but‐3‐enyl)‐2‐(1‐alkynyl)benzenes: Dual Role of the Pt Catalyst.
Authors: Bajracharya Gan B. , Nakamura Itaru , Yamamoto Yoshinori
Published: May 2005

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Masked 3‐Aminoindan‐1‐ones by a Palladium‐Catalyzed Three‐Component Annulation Reaction.
Authors: Arefalk Anna , Larhed Mats , Hallberg Anders
Published: May 2005

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First Synthesis of Enantiopure 1,6‐Difunctionalized Dodecahydrobenz[f]indenes.
Authors: Scaglione Jamie B. , Rath Nigam P. , Covey Doublas F.
Published: May 2005

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Influence of Polymerization Degree of Poly‐L‐Leucine Catalyst and Substituent Effect on the Julia‐Colonna Asymmetric Epoxidation of Benzalacetophenones.
Authors: Takagi Ryukichi , Begum Shahnaz , Siraki Akiko , Yoneshige Arata , Koyama Kin‐ichirou , Ohkata Katsuo
Published: May 2005

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Fluorinated Chiral Secondary Amines as Catalysts for Epoxidation of Olefins with Oxone.
Authors: Ho Chun‐Yu , Chen Ying‐Chun , Wong Man‐Kin , Yang Dan
Published: May 2005

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Tetracyanoethylene Oxide Not Only Oxidizes Sulfides to Sulfoxides but also Reduces Sulfoxides to Sulfides.
Authors: Nakayama Juzo , Tai Ayako , Iwasa Sachiko , Furuya Tomohiro , Sugihara Yoshiaki
Published: May 2005

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Highly Diastereoselective Synthesis of Tetrahydrofurans via Lewis Acid Catalyzed Cyclopropane/Aldehyde Cycloadditions.
Authors: Pohlhaus Patrick D. , Johnson Jeffrey S.
Published: May 2005

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I‐‐Catalyzed Methyl—Oxygen Bond Cleavage in 2‐Methoxyfurans. An Efficient Synthesis of Butenolides.
Authors: Ma Shengming , Lu Lianghua , Lu Ping
Published: May 2005

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Reaction of β,β‐Dinitrostyrenes with Acetylacetone.
Authors: Trukhin E. V. , Sheremet E. A. , Masalovich M. S. , Berestovitskaya V. M.
Published: May 2005

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Synthesis and Antibacterial Activities of 5‐Hydroxy‐4‐amino‐2(5H)‐furanones.
Authors: Lattmann Eric , Dunn Simon , Niamsanit Suwanna , Sattayasai Nison
Published: May 2005

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Diels—Alder Reaction and Double Phenylation in Reaction of Thiophenes with Diphenyliodonium Triflate.
Authors: Zhang Bian‐Xiang , Nuka Takato , Fujiwara Yuzo , Yamaji Teizo , Hou Zhaomin , Kitamura Tsugio
Published: May 2005

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Organolanthanoid‐Catalyzed Intramolecular 5‐endo‐dig Hydroamination: An Unusual anti‐Markovnikov Cyclization.
Authors: Molander Gary A. , Hasegawa Hikaru
Published: May 2005

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4,5‐Disubstituted cis‐Pyrrolidinones as Inhibitors of 17β‐Hydroxysteroid Dehydrogenase II. Part 1. Synthetic Approach.
Authors: Cook James H. , Barzya Jeremy , Brennan Catherine , Lowe Derek , Wang Yamin , Redman Aniko , Scott Wiliam J. , Wood Jill E.
Published: May 2005

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Bis(aminopyrrolidine)‐Derived Ureas (APUs) as Potent MCH1 Receptor Antagonists.
Authors: Dyck Brian , et al. et al.
Published: May 2005

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Novel Isoindoline Compounds for Potent and Selective Inhibition of Prolyl Dipeptidase DPP8.
Authors: Jiaang Weir‐Torn , Chen Yuan‐Shou , Hsu Tsu , Wu Ssu‐Hui , Chien Chia‐Hui , Chang Chung‐Nien , Chang Sheng‐Ping , Lee Shiow‐Ju , Chen Xin
Published: May 2005

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The Facile and Efficient Michael Addition of Indoles and Pyrrole to α,β‐Unsaturated Electron‐Deficient Compounds Catalyzed by Aluminum Dodecyl Sulfate Trihydrate [Al(DS)3]×3H2O in Water.
Authors: Firouzabadi Habib , Iranpoor Nasser , Nowrouzi Farhad
Published: May 2005

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Reactions of 3‐Phenyl‐8‐triphenylphosphoimino‐1‐azaazulene with Aryl Isocyanate, Aryl Isothiocyanate, and Carbon Disulfide.
Authors: Nagamatsu Kentaro , Fujii Hiroyuki , Abe Noritaka , Kakehi Akikazu
Published: May 2005

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Synthesis and in vitro Selective anti‐Helicobacter pylori Activity of Pyrazoline Derivatives.
Authors: Bizzarri B. , et al. et al.
Published: May 2005

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2‐Mercaptoimidazoles, a New Class of Potent CCR2 Antagonists.
Authors: Van Lommen Guy , Doyon Julien , Coesemans Erwin , Boeckx Staf , Cools Marina , Buntinx Mieke , Hermans Bart , VanWauwe Jean
Published: May 2005

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Benzimidazole Derivatives as Novel Nonpeptide Luteinizing Hormone‐Releasing Hormone (LHRH) Antagonists. Part 1. Benzimidazole‐5‐sulfonamides.
Authors: Hashimoto Kentaro , et al. et al.
Published: May 2005

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Design, Synthesis, and Evaluation of Oxazole Transthyretin Amyloidogenesis Inhibitors.
Authors: Razavi Hossein , Powers Evan T. , Purkey Hans E. , Adamski‐Werner Sara L. , Chiang Kyle P. , Dendle Maria T. A. , Kelly Jeffery W.
Published: May 2005

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A New Facile Chemoenzymatic Synthesis of Levamisole.
Authors: Kamal Ahmed , Khanna G. B. Ramesh , Krishnaji T. , Ramu R.
Published: May 2005

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Non‐peptidic Small Molecule Inhibitors of XIAP.
Authors: Park Cheol‐Min , Sun Chaohong , Olejniczak Edward T. , Wilson Alan E. , Meadows Robert P. , Betz Stephen F. , Elmore Steven W. , Fesik Stephen W.
Published: May 2005

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1,3‐Dipolar Cycloaddition of Trimethylsilyl Azide to Propynals and Dimerization of 1H‐1,2,3‐Triazole‐5‐carbaldehydes to Tricyclic Bis‐hemiaminals.
Authors: Demina M. M. , Novopashin P. S. , Sarapulova G. I. , Larina L. I. , Smolin A. S. , Fundamenskii V. S. , Kashaev A. A. , Medvedeva A. S.
Published: May 2005

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Synthesis of 4H,5H‐Pyrano[3,2‐c][1]benzopyran‐5‐ones in Aqueous Media.
Authors: Wang Jing , Shi Daqing , Zhuang Qiya , Wang Xiangshan , Hu Hongwen
Published: May 2005

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One‐Pot Synthesis of 2‐Amino‐4‐aryl‐5‐oxo‐5,6,7,8‐tetrahydro‐4H‐1‐benzopyran‐3‐carbonitriles in Aqueous Media.
Authors: Shi Daqing , Mou Jie , Zhuang Qiya , Wang Xiangshan
Published: May 2005

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Studies on Novel Synthetic Methodologies. Part 47. Synthesis of Coumarins via a Pechmann Condensation Using Heterogeneous Catalysts.
Authors: Das Biswanath , Venkateswarlu Katta , Mahender Gurram , Holla Harish
Published: May 2005

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Novel 3‐Aminochromans as Potential Pharmacological Tools for the Serotonin 5‐HT7 Receptor.
Authors: Holmberg Paer , Tedenborg Lars , Rosqvist Susanne , Johansson Anette M.
Published: May 2005

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Direct Synthesis of Heterobiaryls by Radical Addition to Pyridine: Expeditious Synthesis of Chelating Ligands.
Authors: Crich David , Patel Mitesh
Published: May 2005

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Palladium‐Catalyzed C—C Coupling Reactions in the Enantioselective Synthesis of 2,4‐Disubstituted 4,5‐Dehydropiperidines Using Galactosylamine as a Stereodifferentiating Auxiliary.
Authors: Knauer Stephen , Kunz Horst
Published: May 2005

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An Efficient Route to 5,5′′‐Diaryl‐2,2′:6′,2′′‐terpyridines Through 2,6‐Bis(1,2,4‐triazin‐3‐yl)pyridines.
Authors: Kozhevnikov Valery N. , Kozhevnikov Dmitry N. , Shabunina Olga V. , Rusinov Vladimir L. , Chupakhin Oleg N.
Published: May 2005

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Synthesis and SAR Studies of 3‐Phenoxypropyl Piperidine Analogues as ORL1 (NOP) Receptor Agonists.
Authors: Palin Ronald , et al. et al.
Published: May 2005

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Discovery of 2,3,5‐Trisubstituted Pyridine Derivatives as Potent Akt1 and Akt2 Dual Inhibitors.
Authors: Zhao Zhijian , et al. et al.
Published: May 2005

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Synthesis of Isoquinoline Derivatives Using ROM—RCM of Cyclobutene‐yne.
Authors: Mori Miwako , Wakamatsu Hideaki , Tonogaki Keisuke , Fujita Reiko , Kitamura Tsuyoshi , Sato Yoshihiro
Published: May 2005

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1‐(Phenyl)isoquinoline Carboxamides: A Novel Class of Subtype Selective Inhibitors of Thyrotropin‐Releasing Hormone (TRH) Receptors.
Authors: Jiang Jian‐kang , Thomas Craig J. , Neumann Susanne , Lu Xinping , Rice Kenner C. , Gershengorn Marvin C.
Published: May 2005

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Synthesis of Imidazo[1,2‐a][1,8]naphthyridines under Microwave Irradiation.
Authors: Mogilaiah K. , Reddy G. Randheer , Reddy Ch. Srinivas
Published: May 2005

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Quinazolinethiones and Quinazolinediones, Novel Inhibitors of Inosine Monophosphate Dehydrogenase: Synthesis and Initial Structure—Activity Relationships.
Authors: Haughan Alan F. , et al. et al.
Published: May 2005

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The Discovery of a Selective, High Affinity A2B Adenosine Receptor Antagonist for the Potential Treatment of Asthma.
Authors: Zablocki Jeff , et al. et al.
Published: May 2005

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4‐(2‐Pyridyl)piperazine‐1‐benzimidazoles as Potent TRPV1 Antagonists.
Authors: Shao Bin , Huang Jincheng , Sun Qun , Valenzano Kenneth J. , Schmid Lori , Nolan Scott
Published: May 2005

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Allosteric Akt (PKB) Inhibitors: Discovery and SAR of Isozyme Selective Inhibitors.
Authors: Lindsley Craig W. , et al. et al.
Published: May 2005

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Syntheses and Properties of the Major Hydroxy Metabolites in Humans of Blonanserin AD‐5423, a Novel Antipsychotic Agent.
Authors: Ochi Takeshi , Sakamoto Masato , Minamida Akira , Suzuki Kenji , Ueda Tomohiko , Une Teruaki , Toda Hiroshi , Matsumoto Kazuya , Terauchi Yoshiaki
Published: May 2005

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A Convenient One‐Pot Synthesis of Asymmetric 1,3,5‐Triazine‐2,4,6‐triones and Its Application Towards a Novel Class of Gonadotropin‐Releasing Hormone Receptor Antagonists.
Authors: Guo Zhiqiang , Wu Dongpei , Zhu Yun‐Fei , Tucci Fabio C. , Pontillo Joseph , Saunders John , Xie Qiu , Struthers R. Scott , Chen Chen
Published: May 2005

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Antinociceptive Activity of New Imidazolidine Carbonyl Derivatives. Part 4. Synthesis and Pharmacological Activity of 8‐Aryl‐3,4‐dioxo‐2H,8H‐6,7‐dihydroimidazo[2,1‐c][1,2,4]triazines.
Authors: Sztanke Krzysztof , Fidecka Sylwia , Kedzierska Ewa , Karczmarzyk Zbigniew , Pihlaja Kalevi , Matosiuk Dariusz
Published: May 2005

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1‐Aryl‐4,6‐diamino‐1,2‐dihydrotriazine as Antimalarial Agent: A New Synthetic Route.
Authors: Kidwai M. , Mothsra P. , Mohan R. , Biswas S.
Published: May 2005

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Novel Spiroanellated 1,2,4‐Trioxanes with High in vitro Antimalarial Activities.
Authors: Griesbeck Axel G. , El‐Idressy Tamer T. , Hoeinck Lars‐Oliver , Lex Johann , Brun Reto
Published: May 2005

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1,4‐Benzodiazepine‐2,5‐diones as Small Molecule Antagonists of the HDM2—p53 Interaction: Discovery and SAR.
Authors: Lu Tianbao
Published: May 2005

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The Development of Potent and Selective Bisarylmaleimide GSK3 Inhibitors.
Authors: Engler Thomas A. , et al. et al.
Published: May 2005

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New Synthetic Approach to Substituted 4,5‐Dihydro‐1,3‐dioxepines
Authors: Fedorenko V. Yu. , Bulygina T. V. , Shtyrlin Yu. G. , Klimovitskii E. N.
Published: May 2005

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Access to the New Isoindolo[1,3]benzothiazocinones via the Combination of N‐Acyliminium Chemistry and Friedel—Crafts Type π‐Cyclization.
Authors: Cul Armelle , Daich Adam , Decroix Bernard , Sanz Gerard , Van Hijfte Luc
Published: May 2005

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Reactions of Phenylenedioxytrihalophosphoranes with Arylacetylenes. Part 7. Reaction of 2,2,2‐Trichloro‐4‐fluoro‐1,3,2λ5‐benzodioxaphosphole with Phenylacetylene.
Authors: Mironov V. F. , Shtyrlina A. A. , Varaksina E. N. , Efremov Yu. Ya. , Konovalov A. I.
Published: May 2005

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Synthesis and Antifungal Activity of Noble 5‐Arylamino‐ and 6‐Arylthio‐4,7‐dioxobenzoselenazoles.
Authors: Ryu Chung‐Kyu , Han Ja‐Young , Jung Ok‐Jai , Lee Su‐Kyung , Lee Jung Yoon , Jeong Seong Hee
Published: May 2005

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Total Synthesis of (+)‐Kuhistaferone
Authors: Fujita Mari , Shindo Mitsuru , Shishido Kozo
Published: May 2005

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Suberoretisteroids A—E, Five New Uncommon Polyoxygenated Steroid 24‐Ketals from the Hainan Gorgonian Suberogorgia reticulata
Authors: Zhang Wen , Guo Yue‐Wei , Gavagnin Margherita , Mollo Ernesto , Cimino Guido
Published: May 2005

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Synthesis and Antagonist Activities of 4‐Aryl‐Substituted Conformationally Restricted Cyclopentenyl and Cyclopentanyl‐Glutamate Analogues.
Authors: Ung Alison T. , Pyne Stephen G. , Batenburg‐Nguyen Uta , Davies Andrew S. , Sherif Azlifa , Bischoff Francois , Lesage Anne S. J.
Published: May 2005

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Structure‐Based Design, Synthesis and Biochemical Testing of Novel and Potent Smac Peptido‐Mimetics.
Authors: Sun Haiying , Nikolovska‐Coleska Zaneta , Chen Jianyong , Yang Chao‐Yie , Tomita York , Pan Hongguang , Yoshioka Yoshiko , Krajewski Krzysztof , Roller Peter P. , Wang Shaomeng
Published: May 2005

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Synthesis and Tuberculostatic Activity of Methyl Esters of Some Amino Acids with Symm‐Tetrazine Moieties.
Authors: Rusinov G. L. , Latosh N. I. , Ishmetova R. I. , Kravchenko M. A. , Ganebnykh I. N. , Sokolov V. A. , Chupakhin O. N.
Published: May 2005

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Polyhydroxyazepanes Mimicking Monosaccharides: Synthesis of an α‐D‐Galacto‐Like Iminoheptitol.
Authors: Li Hongqing , Bleriot Yves , Mallet Jean‐Maurice , Zhang Yongmin , Rodriguez‐Garcia Eliazar , Vogel Pierre , Mari Silvia , Jimenez‐Barbero Jesus , Sinay Pierre
Published: May 2005

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Thiomidoyl Approach to the Synthesis of α‐Sialosides.
Authors: De Meo Cristina , Parker Olivia
Published: May 2005

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Applying Asymmetric Dihydroxylation to the Synthesis of Difluorinated Carbohydrate Analogues: A 1,1‐Difluoro‐1‐deoxy‐D‐xylulose.
Authors: Cox Liam R. , DeBoos Gareth A. , Fullbrook Jeremy J. , Percy Jonathan M. , Spencer Neil
Published: May 2005

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The Chemistry of Indoles. Part 124. Short‐Step Synthesis of an Antibiotic, 6‐Cyano‐5‐methoxy‐12‐methylindolo[2,3‐a]carbazole.
Authors: Somei Masanori , Yamada Fumio , Suzuki Yoshiaki , Ohmoto Shinobu , Hayashi Hiroyuki
Published: May 2005

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Total Synthesis of the Tricyclic Marine Alkaloids (‐)‐Lepadiformine, (+)‐Cylindricine C, and (‐)‐Fasicularin via a Common Intermediate Formed by Formic Acid‐Induced Intramolecular Conjugate Azaspirocyclization.
Authors: Abe Hideki , Aoyagi Sakae , Kibayashi Chihiro
Published: May 2005

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Preparation of 2′,3′‐Oxirane‐Fused Carbocyclic Nucleosides Based on N‐Substituted 2‐Azabicyclo[2.2.1]hept‐5‐en‐3‐ones.
Authors: Ishikura Minoru , Matsumoto Kota , Murakami Atsushi
Published: May 2005

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Stereoselective Synthesis of 9‐β‐D‐Arabianofuranosyl Guanine and 2‐Amino‐9‐(β‐D‐arabianofuranosyl)purine.
Authors: Yu Xue‐Jun , Li Gai‐Xia , Qi Xiou‐Xiang , Deng You‐Quan
Published: May 2005

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Discovery and Synthesis of a Potent, Selective and Orally Bioavailable EP4 Receptor Agonist
Authors: Young Robert N. , et al. et al.
Published: May 2005

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Ring‐Closing Metathesis Approach to Dictyostatin.
Authors: Kangani Cyrous O. , Brueckner Arndt M. , Curran Dennis P.
Published: May 2005

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Marine Bacteria. Part 28. Anticancer and Antibacterial Trioxacarcins with High Antimalaria Activity from a Marine Streptomycete and Their Absolute Stereochemistry
Authors: Maskey Rajendra P. , Helmke Elisabeth , Kayser Oliver , Fiebig Heinz H. , Maier Armin , Busche Andreas , Laatsch Hartmut
Published: May 2005

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Synthesis of Lanopylin B1.
Authors: Snider Barry B. , Zhou Jingye
Published: May 2005

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CRM‐51006, a New Phospholipase C (PLC) Inhibitor, Produced by Unidentified Fungal Strain MT51005
Authors: Oh Won Keun , Oh Hyuncheol , Kim Bo Yeon , Kim Beom Seok , Ahn Jong Seog
Published: May 2005

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YM‐92447 (Spinosulfate A), a Neuraminidase Inhibitor Produced by an Unidentified Pycnidial Fungus
Authors: Shibazaki Mitsuyoshi , Tanaka Koichi , Nagai Koji , Watanabe Masato , Fujita Shigeo , Suzuki Kenichi , Okada Gen , Yamamoto Tomoko
Published: May 2005

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Solventless Synthesis of Bi2S3 (Bismuthinite) Nanorods, Nanowires, and Nanofabric.
Authors: Sigman Michael B. Jr. , Korgel Brian A.
Published: May 2005

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Hydrothermal Synthesis of Ultralong and Single‐Crystalline Cd(OH)2 Nanowires Using Alkali Salts as Mineralizers.
Authors: Tang Bo , Zhuo Linhai , Ge Jiechao , Niu Jinye , Shi Zhiqiang
Published: May 2005

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Structure and Thermal Stability of Novel Fluorophosphate Glasses.
Authors: Sun Hongtao , Zhang Liyan , Xu Shiqing , Dai Shixun , Zhang Junjie , Hu Lili , Jiang Zhonghong
Published: May 2005

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Gas‐Phase Catalysis by Atomic and Cluster Metal Ions: The Ultimate Single‐Site Catalysts
Authors: Boehme Diethard K. , Schwarz Helmut
Published: May 2005

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Thermal Conductivity of Crystalline and Amorphous Ices and Its Implications on Amorphization and Glassy Water
Authors: Andersson Ove , Inaba Akira
Published: May 2005

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A Combined Vacuum Ultraviolet Laser and Synchrotron Pulsed Field Ionization Study of BCl3
Authors: Yang Jie , Mo Yuxiang , Lau K. C. , Song Y. , Qian X. M. , Ng C. Y.
Published: May 2005

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One‐Dimensional Assemblies of Nanoparticles: Preparation, Properties, and Promise
Authors: Tang Zhiyong , Kotov Nicholas A.
Published: May 2005

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Half‐Sandwich‐Type Complexes with Non‐Fischer‐Type Carbene Ligands: Synthesis, Molecular Structure, Substitution, and C—C Coupling Reactions
Authors: Werner Helmut
Published: May 2005

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Polymorphism and Luminescent Behavior of Linear, Two‐Coordinate Gold(I) Complexes
Authors: Balch Alan L.
Published: May 2005

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Silver(I) —N‐Heterocyclic Carbenes
Authors: Lin Ivan J. B. , Vasam Chandra Sekhar
Published: May 2005

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Heteropolyalanes, ‐Gallanes, ‐Indanes, and ‐Thallanes
Authors: Uhl Werner , Roesky Herbert W.
Published: May 2005

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Single Electron Transfer Reactions in the Synthetic Organometallic Chemistry of First‐Row Transition Metals.
Authors: Smith Kevin M.
Published: May 2005

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Approaches to the Total Synthesis of Calycotomine, a Widespread 1‐Hydroxymethyl‐Substituted Simple Tetrahydroisoquinoline
Authors: Kaufman Teodoro S.
Published: May 2005

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Regioselective Cross‐Coupling Reactions of Multiple Halogenated Nitrogen‐, Oxygen‐, and Sulfur‐Containing Heterocycles
Authors: Schroeter Sven , Stock Christoph , Bach Thorsten
Published: May 2005

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Phosphazenes with Pyridine Groups
Authors: Diefenbach Ursula
Published: May 2005

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Carbohydrates: From “Chirons” to New Glycosubstances
Authors: Sharma G. V. M. , Krishna Palakodety Radha
Published: May 2005

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Chemistry of N‐(1H‐indol‐3‐ylmethyl)‐N,N‐dimethylamine (Gramine)
Authors: Semenov B. B. , Granik V. G.
Published: May 2005

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Phospho‐Transfer Processes Leading to P—C Bond Formation
Authors: Fletcher Matthew D.
Published: May 2005

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The Wittig and Related Reactions
Authors: Abell Andrew D. , Edmonds Michael K.
Published: May 2005

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Applications of Phosphorus (III) and (V) Compounds as Reagents in Synthesis
Authors: Aitken R. Alan , Karodia Nazira
Published: May 2005

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Organolithium in Asymmetric Processes
Authors: Wu George G. , Huang Mingsheng
Published: May 2005

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Application of Microwave Irradiation, Solid Supports and Catalysts in Environmentally Benign Heterocyclic Chemistry
Authors: Carrillo Jose Ramon , Diaz‐Ortiz Angel , De La Hoz Antonio , Moreno Andres , Gomez Maria Victoria , Prieto Pilar , Sanchez‐Migallon Ana , Vazquez Ester
Published: May 2005

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Recent Developments in the Chemistry of Isoxazol‐5‐ones
Authors: Beccalli Egle Maria , Pocar Donato , Zoni Caterina
Published: May 2005

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Unique Synthetic Opportunities on the Borderline of Cyclophosphazene Chemistry and Supramolecular Chemistry
Authors: Brandt Krystyna
Published: May 2005

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Construction and Functionality of Supramolecules Based on Cyclotriphosphazenes
Authors: Inoue Kenzo , Itaya Tomoyuki
Published: May 2005

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Microtubule‐Stabilizing Agents as a New Breakthrough in Tumor Therapy: Total Synthesis of Laulimalide
Authors: Mulzer Johann
Published: May 2005

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Nitropyridines: A Partnership of Technologies
Authors: Lush Rachel , McCarthy Paul , Arber Anthony , Millar Ross
Published: May 2005

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Aryl Ketones
Authors: Campagne J. M. , Six Y.
Published: May 2005

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Synthesis of Sumanene, a Fullerene Fragment
Authors: Kellogg Richard M.
Published: May 2005

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Cyclopropanones and Their Precursors
Authors: Salaun J.
Published: May 2005

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Cyclobutanones and Their Precursors
Authors: Salaun J.
Published: May 2005

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Homogeneous Transition Metal Catalyzed Enantioselective Reductive Amination
Authors: Tararov Vitali I. , Kadyrov Renat , Riermeier Thomas H. , Boerner Armin
Published: May 2005

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Sulfonate Leaving Groups for Nucleophilic Substitution Reactions: Improved Structures and Procedures
Authors: Netscher Thomas
Published: May 2005

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The Passerini Reaction
Authors: Banfi Luca , Riva Renata
Published: May 2005

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Saturated and Unsaturated Ketones with a β‐ or More Remote Heteroatom Substituent
Authors: Harrison‐Marchand A. , Chataigner I. , Maddaluno J.
Published: May 2005

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Saturated and Unsaturated Ketones with an Additional Carbonyl, Nitrile, or Carboxy Substituent or Equivalent at a β‐ or More Remote Position: Synthesis of the Ketone Functionality
Authors: Chataigner I. , Harrison‐Marchand A. , Maddaluno J.
Published: May 2005

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Enones
Authors: Marsden S. P.
Published: May 2005

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Ynones
Authors: Nelson A.
Published: May 2005

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α‐Heterosubstituted Ketones
Authors: Suffert J.
Published: May 2005

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α,α‐Diheterosubstituted Ketones
Authors: Parrain J.‐L. , Thibonnet J.
Published: May 2005

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Synthesis from Enones by Formation of C—C Bonds
Authors: Plaquevent J.‐C. , Cahard D. , Guillen F.
Published: May 2005

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Synthesis from Other Ketones
Authors: Plaquevent J.‐C. , Cahard D. , Guillen F.
Published: May 2005

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Synthesis by Addition
Authors: Figadere B. , Franck X.
Published: May 2005

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Synthesis from Thioketones, Acetals, Cyanohydrins, Enol Ethers, Enamines, Other Ene Derivatives, and Related Compounds
Authors: Desmaele D.
Published: May 2005

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Recent Applications of Trifluoroacetaldehyde Ethyl Hemiacetal for the Synthesis of Trifluoromethylated Compounds
Authors: Gong Yuefa , Kato Katsuya
Published: May 2005

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Introduction to Heteroatom Analogues of Aldehydes and Ketones
Authors: Padwa A.
Published: May 2005

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Regio‐ and Stereoselective Addition Reactions of Carbon Nucleophiles to Epoxides
Authors: Crotti Paolo , Di Bussolo Valeria , Macchia Franco , Pineschi Mauro
Published: May 2005

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Fluorous Protecting Groups and Tags for Solution‐Phase Synthesis
Authors: Zhang Wei
Published: May 2005

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Comparative Study of Carbonyl Protecting Groups in the Synthesis of Hydrocortisone‐21‐acetate
Authors: Rehman M. Z. , Kazi A. A. , Ahmad S. , Khan G. R.
Published: May 2005

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Calorimetric and Computational Study of Sulfur‐Containing Six‐Membered Rings
Authors: Juaristi Eusebio , Notario Rafael , Roux Maria Victoria
Published: May 2005

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New Insight to Excitons in Conjugated Polymers
Authors: Kirova N. , Brazovskii S.
Published: May 2005

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Proton‐Coupled Intramolecular Electron Transfer in Ferrocene‐Quinone Conjugated Oligomers and Polymers
Authors: Murata Masaki , Nishihara Hiroshi
Published: May 2005

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Investigations of the Primary Events in a Bacterial Photoreceptor for Photomotility: Photoactive Yellow Protein (PYP)
Authors: Changenet‐Barret Pascale , Espagne Agathe , Plaza Pascal , Hellingwerf K. J. , Martin Monique M.
Published: May 2005

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Cytochrome P450 in Silico: An Integrative Modeling Approach
Authors: de Graaf Chris , Vermeulen Nico P. E. , Feenstra K. Anton
Published: May 2005

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High Rate Production of Hydrogen/Methane from Various Substrates and Wastes
Authors: Nishio Naomichi , Nakashimada Yutaka
Published: May 2005

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On‐Microchip Multiphase Chemistry — A Review of Microreactor Design Principles and Reagent Contacting Modes
Authors: Doku George N. , Verboom Willem , Reinhouldt David N. , van den Berg Albert
Published: May 2005

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Superconducting Magnets and Their Applications
Authors: Gourlay Stephen A. , Sabbi Gianluca , Kircher Francois , Martovetsky Nicolai , Ketchen Don
Published: May 2005

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Molecular Recognition in Organic Crystals: Directed Intermolecular Bonds or Nonlocalized Bonding?
Authors: Dunitz Jack D. , Gavezzotti Angelo
Published: May 2005

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Mechanistic Aspects of Metal‐Catalyzed C—C and C—X Bond‐Forming Reactions
Authors: Echavarren Antonio M. , Cardenas Diego J.
Published: May 2005

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Theoretical Studies on Domino Cycloaddition Reactions
Authors: Domingo Luis R.
Published: May 2005

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Electron and Energy Transfer Modulation with Photochromic Switches
Authors: Raymo Francsco M. , Tomasulo Massimiliano
Published: May 2005

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Postoperative intensity‐modulated radiotherapy in sinonasal carcinoma
Authors: Duthoy Wim , Boterberg Tom , Claus Filip , Ost Piet , Vakaet Luc , Bral Samuel , Duprez Frederic , Van Landuyt Marianne , Vermeersch Hubert , De Neve Wilfried
Published: May 2005

BACKGROUND

Carcinoma of the paranasal sinuses is rare. Standard therapeutic modalities consist of surgery and radiotherapy (RT). Because of the often advanced stage and the vicinity of optic structures, RT‐induced ocular toxicity is a feared side effect of conventional RT. Intensity‐modulated radiotherapy (IMRT) is a relatively new technique, which is implemented with the hypothesis that, compared with conventional RT, it would result in a lower rate of ocular toxicity for an equal local control (LC).

METHODS

Between 1998 and 2003, 39 consecutive patients received postoperative irradiation by means of IMRT for an adenocarcinoma (n = 31) or squamous cell carcinoma (n = 8) of the paranasal sinuses (n = 36) or nasal cavity (n = 3). T‐classification was T2 in 41%, T3 in 15%, T4a in 23%, and T4b in 21% of patients. Invasion through the cribriform plate was seen in 11 patients. Orbital invasion was present in 36% of patients. The median delivered dose was 70 gray (Gy) (range, 60–70 Gy). The authors compared the overall survival (OS) and LC of the patients with a historic cohort (HC) (n = 30), treated with conventional or 3‐dimensional conformal RT.

RESULTS

The median follow‐up was 31 months. The actuarial OS rates were 68% at 2 years and 59% at 4 years. The actuarial LC rates were 73% at 2 years and 68% at 4 years. Invasion through the cribriform plate was a significant prognostic factor for LC and OS, with a median time to local disease recurrence of 7 months if present, and a 2‐year LC rate of 90% if not present. In the comparison between the IMRT and HC groups, no significant differences were found for LC and OS. Acute toxicity was mild. Two patients developed decreased vision after RT. No RT‐induced blindness was observed.

CONCLUSIONS

Postoperative IMRT for sinonasal carcinoma resulted in good LC, with a low acute toxicity and no RT‐induced blindness. Cancer 2005. © 2005 American Cancer Society.
Evaluation of shark cartilage in patients with advanced cancer
Authors: Loprinzi Charles L. , Levitt Ralph , Barton Debra L. , Sloan Jeff A. , Atherton Pam J. , Smith Denise J. , Dakhil Shaker R. , Moore Dennis F. , Krook James E. , Rowland Kendrith M. , Mazurczak Miroslaw A. , Berg Alan R. , Kim George P.
Published: May 2005

BACKGROUND

Shark cartilage has been a popular complementary or alternative medicine intervention. The basis for this popularity is the claim that sharks rarely get cancer because of the high proportion of cartilage in the shark's body. However, early studies were equivocal. Therefore, a clinical trial was conducted to look at the impact of shark cartilage in patients with advanced cancer. The primary goal of this trial was to determine whether a shark cartilage product improved overall survival for patients with advanced cancer who were getting standard care. Secondary research goals were to evaluate toxicities, tolerability, and quality of life associated with this shark cartilage product.

METHODS

The study was a two‐arm, randomized, placebo‐controlled, double‐blind, clinical trial. Patients with incurable breast or colorectal carcinoma had to have good performance status and organ function. Patients could be receiving chemotherapy. Patients were all to receive standard care and then to be randomly selected to receive either a shark cartilage product or an identical‐appearing and smelling placebo 3 to 4 times each day.

RESULTS

Data on a total of 83 evaluable patients were analyzed. There was no difference in overall survival between patients receiving standard care plus a shark cartilage product versus standard care plus placebo. Likewise, there was no suggestion of improvement in quality of life for patients receiving the shark cartilage, compared with those receiving placebo.

CONCLUSION

This trial was unable to demonstrate any suggestion of efficacy for this shark cartilage product in patients with advanced cancer. Cancer 2005. © 2005 American Cancer Society.
A multicenter retrospective study of chemotherapy for recurrent intracranial ependymal tumors in adults by the Gruppo Italiano Cooperativo di Neuro‐Oncologia
Authors: Brandes Alba A. , Cavallo Giovanna , Reni Michele , Tosoni Alicia , Nicolardi Linda , Scopece Luciano , Franceschi Enrico , Sotti Guido , Talacchi Andrea , Turazzi Sergio , Ermani Mario
Published: May 2005

BACKGROUND

No data on the role of chemotherapy in recurrent ependymal tumors are available in adults. The aim of the current study was to investigate outcomes after salvage chemotherapy in this setting.

METHODS

A retrospective review was made of the charts of 28 adults (≥ 18 years) with progressive or recurrent ependymal tumors after surgery and radiotherapy, who received chemotherapy between 1993 and 2003 in 3 institutions of the Gruppo Italiano Cooperativo di Neuro‐Oncologia network.

RESULTS

Thirteen patients (46.3%) received cisplatin‐based chemotherapy (Group A) and 15 (53.7%) received regimens without cisplatin (Group B). Platinum‐based chemotherapy yielded 2 complete responses (CR) (15.4%) and 2 (15.4%) partial responses (PR), whereas 7 patients (53.8%) remained stable (SD). After regimens without cisplatin, there were no CR, 2 PR (13.3%), and 11 SD (73.3%). The overall median time to progression was 9.9 months (95% confidence interval [95% CI], 7.5–21.7 months), 9.9 months (5.2–not reached) for Group A and 10.9 months (95% CI, 7.17–23.9 months) for Group B. The overall median survival (OS) was 40.7 months (95% CI, 16–not reached), 31 months (21–not reached) for Group A and 40.7 months (13.4–not reached) for Group B.

CONCLUSIONS

Cisplatin‐based chemotherapy achieved a higher response rate, but did not prolong disease progression‐free survival or OS. More active regimens for the salvage treatment of ependymal tumors have yet to be found. Cancer 2005. © 2005 American Cancer Society.
Acute leukemia during pregnancy
Authors: Chelghoum Youcef , Vey Norbert , Raffoux Emmanuel , Huguet Françoise , Pigneux Arnaud , Witz Brigitte , Pautas Cécile , de Botton Stéphane , Guyotat Denis , Lioure Bruno , Fegueux Nathalie , Garban Frédéric , Saad Hussam , Thomas Xavier
Published: May 2005

BACKGROUND

Acute leukemia (AL) requiring cytotoxic treatment occurring during pregnancy poses a very difficult therapeutic dilemma.

METHODS

By means of a mail questionnaire, information on a series of 37 patients with a diagnosis of AL during pregnancy was collected from 13 French centers between December, 1988 and November, 2003.

RESULTS

Thirty‐one patients had acute myeloid leukemia (AML), and 6 patients had acute lymphoblastic leukemia (ALL). Nine patients were diagnosed during the first trimester, 10 patients were diagnosed during the second trimester, and 18 patients were diagnosed during the third trimester. Fifteen pregnancies ended with therapeutic or spontaneous abortion. There were 13 normal deliveries, including 1 gemellary pregnancy, and 9 Cesarean sections. Twenty‐three healthy babies survived from the 37 pregnancies, of whom 15 babies had been exposed to chemotherapeutic agents. A complete remission was achieved in 34 patients. Eleven women had severe extrahematologic complications during the induction remission course. The median disease‐free survival (DFS) was not reached, with a 5‐year DFS of 54%. Ten patients developed recurrent disease. Overall, 12 of 37 pregnant women died from leukemia.

CONCLUSIONS

Pregnancy does not affect the course of AL. In the first trimester, termination of pregnancy should be discussed because of the potential fetal consequences of chemotherapy. Chemotherapy treatment during the second or third trimester may not require termination of pregnancy, because as remission of AL and delivery of a normal infant are likely to be obtained. Cancer 2005. © 2005 American Cancer Society.