bluuebunny/crossref_metadata_2025 huggingface dataset:
Rare Immune-Related Adverse Events. A Clinical Case of Sjögren's Syndrome on the Background of Immunotherapy in а Patient with Lung Adenocarcinoma
Authors:   National Medical Research Radiological Center, Karagodina Yu.B. , Ruban M.S. , Savchina V.V. , Bolotina L.V. , Fedenko A.A. , Kornietskaya A.L.
Published: May 2024

Given the rapid expansion of indications for immune checkpoint inhibitors therapy in the clinical practice of oncologists, as well as the emergence of new drugs with similar mechanisms of action, knowledge of rare immune-related adverse events is extremely important for physicians, both in terms of their early detection and optimisation of treatment tactics. Despite their rarity, the spectrum of rheumatological manifestations is quite broad, which requires the continued detailed accumulation and analysis of clinical material. The present clinical observation convincingly demonstrates that when prescribing immune checkpoint inhibitors in case of symptoms suspicious of Sjögren's syndrome, a thorough history and a complete examination, including specialized diagnostic tests to evaluate salivary and lacrimal gland function, should be performed. The differential diagnosis of Sjögren's syndrome with other nosologies requires serum autoantibody testing and salivary gland biopsy. Prompt referral of the patient to a rheumatologist is critical, to avoid delay in making a correct diagnosis. Early diagnosis and timely treatment of toxic reactions are the key to successful anti-tumour therapy. Achieving this goal requires close collaboration between multidisciplinary physicians, the patient, and the patient's family.
Analysis of the Incidence of Colorectal Cancer in the Krasnoyarsk Region
Authors:   V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Zukov R.A. , Serbayeva M.S. , Safontsev I.P. , Zabrodskaya T.Ye. , Gorbunova Ye.A. ,   A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary, Karapetyan A.M.
Published: May 2024

The article analyzes the incidence rates of colorectal cancer in men and women of the Krasnoyarsk region over the past 10 years. Based on the considered trends, forecasts for the further epidemiological situation are made and population groups are selected in which the primary search for oncological pathology of the colon and rectum at an early stage should be concentrated in the near future.
Efficiency and Safety of Pantoprazol in Treatment of Patients with Acid Dependent Diseases in Russia: Multicenter Observe Research
Authors:   Russian University of Medicine, Moscow, Mayev I.V. , Zaborovsky A.V. , Tararina L.A. , Andreev D.N. , Yunina D.V.
Published: May 2024

The aim – evaluate the clinical effect and adherence to pantoprazole (Nolpaza®) therapy in patients with acid-dependent diseases in real clinical practice. Pantoprazole occupies a special place among various representatives of proton pump inhibitors (PPI) due to the peculiarities of its pharmacokinetics and pharmacodynamics. Thus, the area under the curve (AUC), correlating with the severity of acid-suppressive effect, is significantly higher for pantoprazole than for other PPIs. In addition, pantoprazole has a longer-lasting antisecretory effect because it is the only PPI that binds to both cysteine 813 and deep-lying cysteine 822. Of all PPIs, pantoprazole least blocks the CYP2C19 isoenzyme involved in multidrug metabolism, ensuring minimal drug interactions. Material and methods. Data collection for further analysis was performed using specially designed electronic individual registration cards of two groups of patients: the first – patients with gastroesophageal reflux disease (GERD), receiving therapy with Nolpaza®; the second – patients with peptic ulcer disease (PU) / erosive gastritis and patients with an indication for Helicobacter pylori eradication, receiving therapy with Nolpaza® as part of the eradication therapy regimen. Conclusion. According to the results of the conducted study it was possible to evaluate the clinical effect and tolerability of Nolpaza® therapy using the data of more than 14 thousand patients with GERD, gastritis, duodenitis, gastric and duodenal ulcer, drug-induced gastropathy, 98% of whom had gastrointestinal complaints before the beginning of treatment, while by the end of therapy the complaints remained in full in less than 1% of patients. The results of esophagogastroduodenoscopy at the end of therapy with Nolpaza® confirmed positive dynamics in 99.8% of cases, and the vast majority of patients achieved complete endoscopic remission. Positive dynamics was also observed in the majority of patients who were tested for H. pylori infection. The efficacy of eradication therapy with Nolpaza® amounted to 88.2%. The study provided a high assessment of patient adherence throughout the follow-up period.
Treatment of Hepatic Failure by Intraportal Administration of Autological Bone Marrow Mononuclear Cells in a Patient With Liver Cirrhosis: the First Experience of the Moscow City Cliniсal Botkin Hospital
Authors:   S.P. Botkin City Clinical Hospital, Moscow, Shabunin А.V. , Bedin V.V. , Pavlov Ch.S. , Levina О.N. , Drozdov P.А. , Oleynik Yu.A. , Chechenin G.M. , Tsurkan V.А. ,   Russian Medical Academy of Continuous Professional Education, Moscow,   Sechenov University, Moscow
Published: May 2024

Hepatic failure is one of the most common manifestation of liver cirrhosis. Currently, there are no medication or invasive procedure, which can reliably improve liver function. Research on the use of autologous bone marrow mononuclear stem cells to correct the morphofunctional manifestations of acute and chronic liver failure is encouraging. This clinical case demonstrates the safety and clinical effectiveness of intraportal administration of autologous bone marrow mononuclear cells obtained by apheresis after stimulation with granulocyte-macrophage colony-stimulating factor.
Comparative Effectiveness of Different Treatment Regimens with Rifaximin-α in Patients with Minimal Hepatic Encephalopathy and Liver Cirrhosis (Analysis of 6-Month Follow-Up)
Authors:   North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Bakulin I.G. , Ivanova K.N. , Abdrakhmanov A.V.
Published: May 2024

Minimal hepatic encephalopathy (MHE) is the earliest and mildest form of hepatic encephalopathy (HE), however, its occurrence is associated with an unfavorable prognosis for cirrhosis in patients in this category. MHE increases the number of falls, injuries, patients getting into road traffic accidents, and accidents, which has serious consequences for the quality of life, and also affects the increase in the frequency of hospitalizations and mortality in patients in this category. Timely correction of cognitive impairment is the key to treating and reversing MHE, as well as improving the quality of life in patients with cirrhosis. Objectives. To study the optimal regimens for the use of rifaximin-α and study its effect on the main clinical and laboratory parameters and quality of life of patients with MHE against the background of cirrhosis during long-term treatment. Material and methods. Inclusion criteria: men and women from 18 to 75 years old; availability of CPU; presence of MHE; signed voluntary informed consent. Non-inclusion criteria: refusal to participate in the study; acute hepatitis; HIV co-infection; severe comorbid pathology; mental illness; Wilson – Konovalov disease. Research methods: clinical examination (analysis of patient complaints, assessment of objective status); laboratory tests (ammonia levels); assessment of the severity of liver disease according to the Child – Pugh scale; assessment of the degree of HE based on the results of psychometric tests (number connection test, animal naming test, brief mental status scale); quality of life questionnaire (SF-36). Results. In the absence of rifaximin-α therapy, there is a deterioration in the quality of life due to a decrease in indicators of the mental component of health, as well as an increase in time in performing the psychometric number connection test. Against the background of continuous and cyclic therapy with rifaximin-α in patients with cirrhosis and MHE during 6 months of observation, the level of capillary blood ammonia decreases. Conclusions. When comparing the effectiveness of continuous and course therapy with rifaximin-α, the results did not show significant differences, which indicates the equivalence of these treatment regimens after 6 months of observations.
A interdisciplinaridade no Ensino Médio como facilitadora da aprendizagem de alunos nas escolas públicas de Inaciolândia-GO
Authors: Queiroz Katia Rubia dos Santos , Neves Adriana Cristina Amuy , Moura Cleine Borges Alves de , Moura Iris Divina Alves de , Silva Joviano Martins da , Silva Geracina Pereira da , Silva Francisca Maria da , Silva Maykon Douglas Ferreira da
Published: May 2024

O estudo em questão concentra-se na prática interdisciplinar no ensino médio, particularmente em escolas públicas localizadas em Inaciolândia-Goiás. O principal objetivo desta pesquisa foi analisar as ações dos professores para promoverem a aprendizagem dos alunos por meio da prática interdisciplinar. Para obter uma visão clara da situação, foi aplicado um questionário estruturado para uma amostra de sessenta professores, caracterizando-se num estudo quantitativo. Este estudo foi descritivo e os dados foram tabulados por meio de gráficos e porcentagens. Por meio deste instrumento, buscou-se capturar as percepções, os desafios e as abordagens pedagógicas relacionadas à prática interdisciplinar. Percebeu-se como a interdisciplinaridade é incorporada na rotina escolar e quais os obstáculos metodológicos e estruturais encontrados pelos educadores. Este estudo evidencia que a interdisciplinaridade é percebida como uma ferramenta pedagógica valiosa, com potencial para enriquecer a experiência educacional dos alunos no ensino médio. No entanto, sua implementação efetiva requer atenção às nuances e desafios apresentados, incluindo a necessidade de formação continuada dos docentes e a disponibilidade de recursos didáticos adequados.
Study of analgesic narcotic medicines range at the regional level
Authors:   Yaroslav-the-Wise Novgorod State University, Antropova G. A. , Stepanova E. N. ,   Center for Certification and Quality Control of Medicinal Products, Okonenko T. I. ,   Yaroslav-the-Wise Novgorod State University
Published: May 2024

Analgesic narcotic analgesics are the basis for the treatment of pain syndromes. Russia is undergoing import substitution processes for the production of narcotic analgesics, and appropriate actions are being taken to ensure the growth of the production base of the pharmaceutical industry. The results of a study of the range of opioid analgesics on the Russian market, as well as in the Novgorod region, are presented. The period of regulation based on prohibitions, restrictions, additional responsibilities, which caused certain problems in the quality of pain therapy, is being replaced by a period of greater concern for the needs of patients. The article shows the processes of a significant increase in the release of narcotic analgesics in sufficient quantities and in various dosage forms. The Novgorod region has a sufficient range of analgesic narcotic analgesics in modern dosage forms.
Growth and Yield Variance and Heritability Estimates among Some Local and Improved Varieties of Bambara Groundnut (Vigna subterranean L. Verdc)
Authors: Mshelmbula Barka , Daniya Umar , Ogah Godwin , Akomolafe Festus , Tsaku Amadu Namson , Ikhajiagbe Beckley
Published: May 2024

The current investigation demonstrated that all the seeds taken into consideration generally had different varietal characteristics with the exception of several growth characteristics, notably the stem girth where the improved varieties outperformed the local Bambara nuts. The local Bambara nut varieties (Jan Iri) had the highest parameters measured compared to others. The huge variation in yield component recorded for this variety made the promise it displayed astounding. Due to the importance of the genotype-by-environment interaction on the expression of all the examined characters, the phenotypic coefficients of variation for each character were all more significant than the genotypic coefficients of variation. Three examined features, including number of pods per plant, number of pods per plot, and number of seeds per plot, all had high heritability estimates (84.96, 99.24, and 99.35, respectively). The quantity of seeds produced by each plant and the dried weight of each plot were moderately recorded at 32.48 and 38.63, respectively. Number of pods per plot (140.01) and number of seeds per plot (176.83) both showed strong genetic advance and with high heritability also. However, fresh weight per plot (109.12) revealed low heredity along with high genetic advance. Looking at the number of seeds per plant, the number of pods per plant, and the number of seeds per plant, a substantial positive association was found.
Modelling seasonal cycle and trends of atmospheric methane by utilising isotopic observations, and insights of methane emissions
Authors:   , Mannisenaho Vilma
Published: May 2024

Methane is one of the greenhouse gases, which have a warming effect on the climate. Methane is emitted to the atmosphere from various processes both naturally and by human actions. The atmospheric concentration of methane has more than doubled since pre-industrial times. In the 21st century methane concentrations were nearly stable until 2006. After that atmospheric methane concentrations started to increase and simultaneously the observed methane carbon stable isotopic ratio started to decrease. The magnitude of methane in the atmosphere is well known, but there are still uncertainties on the contribution of different emissions sources and the magnitude of individual emission sources. The focus of the thesis is the atmospheric trends of methane and its isotopic ratios, and to determine contribution of emissions to seasonal cycles and to improve methane emission estimates for wetlands. Research in this thesis uses methane isotopic source signatures in an atmospheric transport model to separate methane sources. The modelled trends are compared with the trends from observations. The atmospheric trends are produced together by emissions and sinks, and the dominating factors depend on location. Results from this thesis suggest that anthropogenic emissions from Emissions Database for Global Atmospheric Research (EDGAR) inventory need revisions, e.g., the seasonality of emissions does not agree with atmospheric observations. This thesis also suggests that the ratio of biogenic to fossil-based emissions should be re-evaluated. Analysis of atmospheric isotopic trends with observations suggest that fossil-based anthropogenic emissions have been overestimated, and biogenic anthropogenic emissions have been underestimated after 2012.The results from this thesis work demonstrate that combining soil state data from satellites is useful in determining the wetland emissions during the periods when soil is freezing and thawing. Also, it was found that emission estimates of process-based models for wetland emission differ significantly in responses to temperature and precipitation, which may affect the results significantly. This thesis highlights the importance of isotopes in studying methane emissions and the importance of accurate methane emission estimates. This work also demonstrates that satellite-based data on soil state is an effective way to improve methane emission estimates.
Confronting Sexual Abuse in Sacred Spaces
Authors: Editors Intersections
Published: May 2024

This article reviews the special issue of The Revealer which was focused on sexual abuse in the Catholic Church and other places of worship.
The Threat to Sacred Lives, Knowledge, and Landscapes
Authors: Editors Intersections
Published: May 2024

This article describes the research and workshops of "Religion and Climate Change in Cross-Cultural Perspective" project organized by the Center for Latin American and Latino Studies at American University.
Citizen Ethics as Living Traditions
Authors: Editors Intersections
Published: May 2024

This article showcases the edited book Indonesian Pluralities which explores democracy and religious plurality in Indonesia.
The Kremlin and the Russian Orthodox Church: A Homophobic Alliance
Authors: Editors Intersections
Published: May 2024

An article highlighting an episode of the God and Government podcast focused on the anti-LGBTQ political alliance between the Russian government and the Russian Orthodox Church.
What's Wrong With Rights for Children?
Authors: Editors Intersections
Published: May 2024

This article recounts some of the key issues raised by an Emory University conference which investigates the United State's failure to ratify the UN Convention on the Rights of Children.
The Sacred Himalaya Initiative
Authors: Editors Intersections
Published: May 2024

This article details the Sacred Himalaya conference at the New School's India and China Institute which explores the interplay between religion and ecology in the Himalayan region.
Climate Politics and the Power of Religion
Authors: Editors Intersections
Published: May 2024

This article offers a summary of the book Climate Politics and the Power of Religion by Evan Berry.
The Politics of Religion at Home and Abroad
Authors: Editors Intersections
Published: May 2024

This article describes a three-year research project at Northwestern University that explores the relationship between politics, religion, and law in the United States and globally.
COMPREENSÕES E CONCEPÇÕES SOBRE AS TECNOLOGIAS NO CENÁRIO DE FORMAÇÃO DOCENTE EM EDUCAÇÃO FÍSICA
Authors: De Souza Santos Rodrigo , Dorenski Sergio , Mezzaroba Cristiano
Published: May 2024

O cenário de formação docente constantemente é alvo de discussões no que diz respeito às temáticas que envolvem as tecnologias. Muito se discute sobre a inclusão ou não destes elementos nas instituições educacionais, mas pouco se busca identificar e compreender sob quais compreensões e concepções conceituais os professores, responsáveis por mediar os processos educativos, são formados para atuar nesse cenário. Portanto, o objetivo deste trabalho é identificar as concepções e compreensões metodológicas e conceituais das tecnologias no cenário de um curso de formação inicial docente em Educação Física. Para a coleta dos dados, foi aplicado o questionário online por meio de formulários e entrevista semiestruturada, sendo analisados mediante o procedimento da análise de conteúdo. Os resultados apontam o seguinte contexto: 1) a compreensão das tecnologias como linguagem estruturante do contemporâneo. 2) A compreensão de tecnologia como elemento indissociável da cultura docente. 3) a compreensão das tecnologias enquanto artefatos que adentram as instituições com interesses financeiros e mercadológicos. Dessa forma, esse cenário evidencia a necessidade de imersão educacional no campo das tecnologias, cientes das suas diversas concepções epistemológicas, linguagens e narrativas que transcorrem por elas, inclusive no cenário de formação de professores.
INFLUÊNCIA DA ORATÓRIA DE MARCO TÚLIO CÍCERO NA EDUCAÇÃO RETÓRICA DO RATIO STUDIORUM
Authors: Cavalini Gabriel Mingareli , Franco Alexandre Souza
Published: May 2024

Neste trabalho, tem-se por objetivo mostrar a influência da oratória de Marco Túlio Cícero (106 – 43 a.C.) na educação retórica do Ratio Studiorum. Nas pegadas desse processo, apresenta-se um panorama geral dos livros retóricos de Cícero e a proposta do filósofo para a formação do perfeito orador, que se dava por meio de três características essenciais: disposição natural, conhecimento das técnicas do discurso e profunda cultura. Esse ideal humanista do orador ciceroniano fomentará o discurso humanista do século XVI. A Companhia de Jesus, nascida nesse contexto e imbuída pelo espírito humanista de seu tempo, encontrará em Cícero a base da proposta formativa da eloquência, expressa no Ratio Studiorum. Tal formação se dava por meio dos estudos de Gramática, Humanidades e Retórica, tendo por metodologia a prática de preleções, traduções e exercícios de memória.
SISTEM INFORMASI GEOGRAFIS BERBASIS WEB SEBARAN LOKASI FASILITAS KESEHATAN DI KOTA TOMOHON
Authors: Posumah Alfivania Dehelena , Kekenusa John Socrates , Weku Winsy Christo Deilan
Published: May 2024

Perkembangan teknologi saat ini berkembang dengan sangat cepat, bahkan telah menjadi kebutuhan pokok masyarakat di era globalisasi saat ini. Teknologi SIG merupakan teknologi alat bantu yang dapat merepresentasikan dunia nyata di atas monitor komputer. Penelitian ini bertujuan untuk membuat aplikasi sistem informasi geografis berbasis web yang berisi informasi mengenai sebaran lokasi fasilitas kesehatan yang ada di Kota Tomohon. Berdasarkan metode perancangan waterfall dan menggunakan Google Maps API dalam menentukan titik koordinat dari fasilitas kesehatan yang ada dengan menggunakan latitude dan longitude dari tempat wisata tersebut untuk pembuatan WebGIS menunjukan bahwa dengan menggunakan fitur maps yang ada di dalam WebGIS bisa mempermudah masyarakat mengetahui lokasi rumah sakit maupun puskesmas.
Aplikasi Sistem Informasi Taman Pendidikan Al-Qur’an (TPA) Az-Zikra Berbasis Website Menggunakan Metode Rapid Application Development
Authors: Salsabila Nurul Nikma , Kekenusa John Socrates , Ngangi Stephano Caesar Wenston
Published: May 2024

Pada era modern seperti sekarang, pemanfaatan teknologi informasi telah menjadi bagian penting dalam aktivitas sehari-hari. Sistem informasi merupakan sistem yang mengolah data menjadi sebuah informasi dan website sebagai media sarana penyampaian informasi yang menjadi sangat penting. Taman Pendidikan Al-Qur’an (TPA) Az-zikra merupakan lembaga pendidikan non-formal jenis keagamaan komunitas muslim yang menjadikan al-Qur’an sebagai materi utamanya, dan untuk menjadikan generasi muda yang qur’ani dan membumikan Al-Qur’an. Berlokasi di Kecamatan Patampanua, Kabupaten Pinrang, Sulawesi Selatan, dan didirikan pada tahun 2016. Tempat ini memfokuskan bagi anak-anak yang beragama islam dengan rentang usia 7-12 tahun.  Namun, dalam pengelolaan data, TPA Az-zikra menggunakan metode konvensional. Pencatatan pendaftar, santri, pengajar, dan data internal TPA dilakukan secara manual,  menyebabkan data tersebar dan sulit dikelola. Selain itu, minimnya usaha dalam menyebarkan informasi mengenai TPA Az-zikra juga mengakibatkan rendahnya pengetahuan masyarakat tentang lembaga ini. Untuk mengatasi masalah ini, peneliti bertujuan untuk membuat suatu aplikasi sistem informasi berbasis website dengan menggunakan metode rapid application development (RAD). Penelitian ini menghasilkan sebuah aplikasi sistem informasi berbasis website yang dapat digunakan untuk memudahkan pengguna mendaftar menjadi santri pada Taman Pendidikan Al-Qur’an (TPA) Az-zikra secara online, dan pada pihak Taman Pendidikan Al-Qur’an (TPA) Az-zikra akan lebih mudah dalam mengelola data santri, data pengajar dan informasi-informasi penting tentang Taman Pendidikan Al-Qur’an (TPA) Az-zikra agar dapat diketahui oleh masyarakat luar.
SCREENING AND CHARACTERIZATION OF POTENTIAL CYPERMETHRIN-DEGRADING BACTERIA VIA PHENOTYPIC AND MOLECULAR TECHNIQUES
Authors: Aborisade W. T., , Ajao A. T. , Ntagbu F. G. , Lawal R. T.
Published: May 2024

The need for sustainable management of cypermethrin, a widely used synthetic pesticide with significant ecological impact, calls for urgent concerns among environmental stakeholders. Therefore, in this study, the potential cypermethrin-degrading (PCD) bacteria were screened and identified from the soil samples collected from the Cowpea farm of Teaching and Research farm of Kwara State University, Nigeria. The bacterial strains were screened and isolated through enrichment techniques and identified using the standard phenotypic and molecular techniques. The potential for cypermethrin utilisation was determined in the cypermethrin-treated mineral salt medium. The three PCD bacterial strains isolated were PCD1 (Lysinibacillus fusiformis), PCD2 (Bacillus sonorensis), and PCD3 (Achromobacter sp.). Molecular characterization confirmed the identities and revealed high sequence similarity with known species. The accession numbers for these strains are MF973057 (PCD1), MF973058 (PCD2), and MF973059 (PCD3). The growth-dependent utilization of cypermethrin using the optical density values (OD 600 nm) showed the highest OD value on day six (PCD2: 0.60 and PCD3: 0.65) and day nine (PCD1: 0.80) respectively. The observed increases in optical density (OD 600 nm) affirmed their potential for cypermethrin degradation. While the strains exhibit promise in metabolizing cypermethrin, further research is needed to assess their suitability for bioremediation.
VALIDATION OF KEY PERFORMANCE INDICATORS OF MOBILE TELECOMMUNICATION OPERATORS USING ENSEMBLE MODELS AND ARTIFICIAL NEURAL NETWORKS WITH NIGERIAN COMMUNICATION COMMISSION’S THRESHOLDS
Authors: Awofolaju T.T. , Lasisi H.O. , Ajewole T.O. , Adebayo S., , Olawuyi, A.A. , Adeagbo F.M. , Asafa M.O.
Published: May 2024

This paper presents the comparative studies among the predictive models used for the validation of the key parameter indicators of mobile network operators with the Nigerian Communication Commission’s threshold. Four Key Performance Indicators were predicted using artificial neural networks and ensemble models which include bagging and LSBoost models. The Key Performance Indicators and weather parameters for six locations in Southwestern Nigeria were employed. MATLAB R2020a was employed to develop the three models. Microsoft Excel was used in the analysis of the dataset. The bagging model gave the best average compliance of 94% and 100% for CSSR and TCH Congestion Rate respectively while the ANN model yielded the best average compliance of 76.7% and 85.2% for DCR and SDCCH Congestion Rate respectively..
DEVELOPMENT OF A DECISION SUPPORT SYSTEMFOR LEGAL CASE ANALYSIS AND DECISION MAKING USING RECURRENT NEURAL NETWORK
Authors: Sobowale A. A. , Omodunbi B. A. , Abdul-Hameed T. A. , Sobowale P. O. , Amuzat B. J.
Published: May 2024

Over the last few decades, there have been substantial developments in a variety of domains, including computer science, artificial intelligence, and machine learning, which has accelerated the evolution of intelligent systems such as decision support systems with applications in fields such as healthcare, finance, manufacturing, transportation and legal systems. Decision Support Systems (DSS) in legal systems also known as Judicial Decision Support Systems (JDSS) are designed to assist judges and other legal professionals in making legal decisions. JDSS can be used in various areas of law, such as criminal law, civil law, and family law. JDSS can be helpful in various ways, such as reducing the time and effort required to make legal decisions, increasing consistency and fairness in legal decisions, and providing judges and legal professionals with access to relevant legal information and expertise. However, JDSS also have limitations and challenges, such as the need for accurate and up-to-date legal data and the potential for bias in the data or algorithms used in the system. This research work developed a system to assist legal practitioners and it is also designed to enhance the efficiency, transparency, and accessibility of the judicial process. The performance of the developed system was evaluated using some metrics and the following results were obtained: accuracy of 80%, 87% precision, 87% sensitivity/recall and an F1-score of 87%.
Primary Hydatid Cyst of the Abdominal Wall in Children: A Case Report and Literature Review
Authors: Sebahiga C. , Sylla H. , Aballa N. , Ouafi K. El , Fouraiji K. , Saiad M. Oulad
Published: May 2024

Introduction: In endemic areas, hydatid cyst disease is a serious health problem, typically associated with parasitic infections affecting primarily the liver and lungs. However, cases of hydatid cysts in the abdominal wall are rare. We surgically treated a 13-year-old boy with this condition, and we also provided a brief literature review on this topic. Conclusion: Hydatid cyst should be sought in the differential diagnosis of abdominal wall masses. Its preoperative diagnosis plays an important role in preventing rupture with subsequent anaphylaxis and recurrence. Surgery remains the primary treatment modality.
Localization of Hydatid Cysts in Muscle at the Level of the Limbs: About Seven Cases
Authors: Elalouani Elmehdi , Boussouga Mustapha , Berrada Salah
Published: May 2024

Echinicoccose anthropozoonose or hydatidosis is due to larva of a tapeworm: Echinococcus granulosis developped in humans and some animals and transmitted by the dog. A rare localization of hydatid disease is within soft parts. Herein we present a retrospective study of 7 cases with isolated and primary hydatid cyst in peripheral muscles. The preferred population was rural man (85.7%) with mean age of 43.4%, how was consulted for swelling and a very slowly growing mass, and it has grown last 3 months; without any other physical finding at his systemic examination. Thigh is reported to be involved 6 out of 7, 4 at the lodge adductors. Imaging tests and immunological reactions are very helpful in making preoperative diagnosis but histology confirmed that. All patients underwent a surgical excision supplemented by anthelmintics chemotherapy.
ESTRATÉGIAS E IMPLICAÇÕES NO MANEJO TERAPÊUTICO DO QUADRO DEPRESSIVO NA INFÂNCIA E ADOLESCÊNCIA
Authors: Saraiva Silva Júlia , Dalana de Sousa Neves Fabrícia , Dantas de Medeiros Maria Luiza , Bertozo de Lima Ângelo Lucas Mateus , Alves de Aguiar Mellane , Nunes Alves de Sousa Milena
Published: May 2024

Introdução: Os transtornos depressivos são a maior causa de incapacidade em todo o mundo, influenciando negativamente no dia a dia de quem possui o distúrbio. O tratamento em crianças e adolescentes dessa enfermidade apresenta grande relevância, entretanto ainda se revela como uma temática pouco abordada. Objetivo: Analisar estratégias terapêuticas existentes e suas implicações para o tratamento da depressão em crianças e adolescentes. Método: Foi adotado o método de Revisão Sistemática do tipo Integrativa da Literatura. A busca na Publisher Medline e World Wide Science foi efetivada pelo uso dos Descritores em Ciências da Saúde em inglês Therapeutics, Child, Adolescents e Depression, combinados com o operador booleano AND. A partir dos critérios de elegibilidade foram pré-selecionados 1853 artigos e a amostra final se constituiu de 27 documentos. Resultados: As terapias disponíveis no tratamento da depressão em crianças e adolescentes são diversas, apresentando implicações negativas e positivas. Neste sentido, a terapia medicamentosa isolada apresentou resposta positiva, contudo, resultados melhores quando associada à terapia cognitivo comportamental (TCC). Importante mencionar que a TCC isolada não gerou benefícios. As terapias alternativas também abordadas, como a estimulação transmagnética, apresentaram resultados positivos quando usadas como coadjuvantes no tratamento. Conclusão: Diante dos achados, observa-se que a associação entre a terapia cognitiva comportamental e terapia medicamentosa apresenta-se como melhor alternativa terapêutica, apontando diversas implicações positivas na melhora do quadro depressivo de crianças e adolescentes.
IMPACTO DO USO DE PRÓTESE TOTAL NA QUALIDADE DE VIDA DE PACIENTES IDOSOS: REVISÃO DE LITERATURA
Authors: Inácio Araújo Geovanna , Matias de França Gescica Natália , Da Silva Sousa Mota Ana Beatriz , Vieira Andrade Jahnsley Lorran Santiago , Inácio Azevedo Karynne , De Souza Viana Larissa , Rodrigues Dias Marcus Vinicius , Melo Mendes dos Santos Roberta , Furtado Carvalho Roberta
Published: May 2024

INTRODUÇÃO: O edentulismo pode causar diversos problemas físicos e psicológicos, afetando desde a mastigação, até a capacidade de sorrir. No entanto, com o uso da prótese total, esses problemas podem ser minimizados, tendo assim um impacto significativo na qualidade de vida e autoestima dos idosos. OBJETIVOS: Este trabalho tem como objeto de estudo a qualidade de vida dos pacientes idosos que optam pelo uso da prótese total.  METODOLOGIA: Trata-se de uma revisão de literatura integrativa, onde foram utilizados 06 artigos encontrados através da base de dados PubMed e LILACS. Os critérios de inclusão foram artigos da língua português e inglesa, publicados entre os anos de 2018 a 2021. Os critérios de exclusão foram teses, dissertações, artigos pagos e trabalhos de conclusão de curso. RESULTADOS: A perca dentária ainda é uma realidade infeliz para muitos pacientes, especialmente para os idosos. As alterações advindas do edentulismo incluem aos níveis funcional, neuromuscular e fisiológico. Como opção de tratamento para o edentulismo, a prótese total convencional representa uma alternativa viável e segura para a maioria dos pacientes idosos. CONCLUSÃO: O edentulismo em idosos ainda constitui um desafio para os profissionais da odontologia, onde a prótese total tem um impacto significativo na qualidade de vida dos idosos, prevenindo pressão aos tecidos bucais, proporcionando conforto e alívio de dor, devolvendo a capacidade de sorrir sem constrangimento, melhorando sua autoimagem e interação social.
Panorama epidemiológico das internações por Flutter e Fibrilação Atrial no Brasil nos últimos anos
Authors: Lolato Tainara , Alves de Lima Leandro , Henrique Santana Amanda , Santos de Souza Uilma , Souza Barros Rafael , Diego Santana de Freitas Francisco , Hasegawa Iasmin , Leandro Costa Feitosa Vicente , Claudia de Moraes Bastos Castilho Rivas Ana , Santos de Oliveira Bruno , Kristina Magalhães Brito Hellen , Lara de Paula Miranda Ianna
Published: May 2024

Este artigo tem por objetivo analisar o panorama epidemiológico das internações e óbitos por fibrilação atrial e flutter atrial, no Brasil, nos últimos cinco anos. Foram utilizados dados secundários referentes à morbidade hospitalar por fibrilação atrial e flutter atrial disponíveis no site do Departamento de Informática do Sistema Único de Saúde (DATASUS). No Brasil foram registradas 335.317 internações por fibrilação atrial e flutter atrial ocorridos entre 2019 e 2023. Conclui-se que a incidência da fibrilação atrial e flutter se mostrou maior em pacientes do sexo masculino, sendo as mulheres menos acometidas.
A INCIDÊNCIA DA STAPHYLOCOCCUS AUREUS EM HOSPITAIS: REVISÃO DE OBRA
Authors: Nascimento Evelyn Caroline Pantoja do , Santos Pollianna Cristina dos , Castro Samuel Henrique Malcher de
Published: May 2024

O gênero Staphylococcus aureus  (S. aureus) é  um  dos  microrganismos  mais  comuns  no ambiente hospitalar, sendo responsáveis por muitas das infecções adquiridas no hospital. Este patógeno possui  vários  mecanismos  de  virulência,  incluindo  a  formação  de  biofilme  e  a multirresistênciaà antibióticos. Trata-se de uma revisão integrativa de literatura. A busca dos estudos ocorreu entre abril e maio de 2024 nas bases de dados Biblioteca Virtual em Saúde (BVS), PubMed e SciELO. Como descritores foram selecionadas expressões constituintes dos Descritores em Ciências da Saúde (DeCS) da BVS e da Medical Subject Headings (MeSH): “Infecção hospitalar”, “Staphylococcus aureus” e “Resistência a Medicamentos”. A resistência do Staphylococcus aureus a antibióticos é um grande desafio clínico, principalmente devido à rápida disseminação de cepas resistentes. A detecção da Staphylococcus aureus em hospitais pode ser realizada por diferentes métodos, incluindo culturas microbiológicas, testes de suscetibilidade a antibióticos e técnicas moleculares avançadas como a PCR em tempo real. O tratamento de infecções por Staphylococcus aureus geralmente envolve antibioticoterapia e terapia combinada, dependendo da gravidade da infecção. A incidência da Staphylococcus aureus em hospitais é um problema significativo que requer atenção e medidas de controle eficazes. A resistência a antibióticos por parte da bactéria torna o tratamento das infecções mais desafiador, destacando a importância da prevenção.
DESIGN OF A MEDICAL INFORMATION SUBSYSTEM FOR DISPENSARY OBSERVATION
Authors: Новиков М.К. , Коровин Е.Н. , Новикова Е.И. , Сергеева М.А.
Published: May 2024

В настоящее время в РФ проводится всеобщая диспансеризация взрослого населения. Диспансеризация и диспансерное наблюдение необходимы для профилактики, раннего выявления и в дальнейшем квалифицированного лечения хронических неинфекционных заболеваний. Все хронические заболевания развиваются постепенно и не на пустом месте. Условия, при которых вероятность возникновения заболевания становится выше, называются факторами риска. Факторы риска можно выявить задолго до того, как возникнут первые симптомы заболевания, а их коррекция позволяет значительно снизить и даже полностью предупредить развитие заболевания. К тому же выявить эти факторы значительно проще и дешевле, чем потом диагностировать и лечить уже развившийся недуг. Кроме того, выявление заболевания на ранних стадиях его развития позволяет значительно быстрее и эффективнее провести лечение и даже достигнуть полного выздоровления. Для разработки подсистемы для диспансерного наблюдения была построена контекстная диаграмма деятельности и диаграммы декомпозиции, диаграммы классов, и разработана структурированная база данных. С помощью данной подсистемы работник медицинского учреждения сможет регистрировать новых пациентов, заносить их в общую базу, назначать прием, формировать отчеты, а также отображать информацию в цифровом виде на экране монитора, а также в бумажном печатном виде

Currently, the Russian Federation is conducting a general medical examination of the adult population. Clinical examination and clinical observation are necessary for prevention, early detection and further qualified treatment of chronic non-infectious diseases. All chronic diseases develop gradually and not out of nowhere. Conditions that make the disease more likely to occur are called risk factors. Risk factors can be identified long before the first symptoms of the disease appear, and their correction can significantly reduce and even completely prevent the development of the disease. In addition, identifying these factors is much easier and cheaper than later diagnosing and treating an already developed disease. In addition, identifying the disease in the early stages of its development allows treatment to be carried out much faster and more effectively and even to achieve complete recovery. To develop a subsystem for clinical observation, a contextual activity diagram and decomposition diagrams, class diagrams were built, and a structured database was developed. Using this subsystem, a healthcare worker will be able to register new patients, enter them into a common database, make appointments, generate reports, and display information digitally on a monitor screen, as well as in printed paper form
Green Cover Depletion and its Projection over the Upcoming Years
Authors: Rakshan Guptaa
Published: May 2024

The green cover of the Earth, which includes wetlands, grasslands, forests, and other vegetated areas, is essential to preserving ecological balance and promoting biodiversity. However, in recent years, human activities like deforestation, urbanization, and agricultural expansion have been driving an alarming pace of reduction in this essential green cover. The planet's general health, wildlife habitats, and climate change are all significantly impacted by this depletion. It is crucial to comprehend the mechanics of the reduction of green cover and forecast its future trends in order to create conservation plans that work and to lessen environmental damage.
Distracted driving: its Causes and Effects
Authors: Rakshan Guptaa
Published: May 2024

Distracted driving is a major problem for road safety as it is one of the main global causes of collisions and deaths. Distracted driving rates are still startlingly high even with major improvements in car safety systems and laws. This widespread problem demands a thorough examination of its origins and consequences, especially from the perspective of data science, which provides strong instruments and techniques for deciphering complicated events. All activities that take attention away from the core job of driving fall under the umbrella phrase of "distracted driving". Three broad categories of distractions exist: visual (distracting one's eyes from the road), manual (distracting one's hands from the wheel), and cognitive (distracting one's thinking from driving). Using a cell phone to text or chat, eating, drinking, interacting with other passengers, and modifying in-car entertainment or navigation systems are typical instances. Because distracted driving is a complex phenomenon that interacts with a range of environmental, behavioral, and technological factors, efforts to reduce its influence are made more difficult.
ТЕОРИЯ САТИРЫ В ТВОРЧЕСТВЕ Ф.А. ЭМИНА
Authors: Ахмадова Т.Х.
Published: May 2024

В статье предпринята попытка рассмотреть роль жанра сатиры в творчестве Ф.А. Эмина, для которого главной целью было говорить правду, стремиться быть верным последователем истины. В своих произведениях он открыто высмеивал «высоких» поэтов, которые стремились превратить творчество в служение божественной поэзии, ставить его выше реальной жизни. Он отрицал необходимость приукрашивать истинную природу вещей, отказывался переименовывать их. Эмин призывал своих читателей видеть ярко и четко представленные пороки и добродетели, не стесняясь описывать красоту добродетели и мерзость порока. Разделял идеи Эмина, Н.И. Новиков считал, что сатира должна быть резкой, остроумной и воздействовать на общество, выявлять и осмеивать недостатки и глупости людей, особенно властей. Отметим, что термин «критический писатель» впервые был употреблен Эминым в 1769 г., когда он принял активное участие в полемике по вопросу о сатире. Также Эмин выступал с защитой сатиры и против самовластия, угнетения и социального неравенства. В романе "Письма Эрнеста и Доравры" поднял вопрос о методе изображения правды жизни, стремясь показать ее такой, какова она на самом деле, не приукрашивая. В своих произведениях он не утаивал мрачные стороны действительности, выступая как противник самовластия, угнетения и социального неравенства, поэтому сатира для Эмина была оружием в борьбе с недостатками современного общества.
ОБ ОСОБЕННОСТЯХ ЯЗЫКА РОМАНА Ф.М. ДОСТОЕВСКОГО «ИДИОТ»
Authors: Джабраилова Л.Э. , Садулаева М.Х.
Published: May 2024

В своей статье мы рассматриваем характерные черты художественного стиля Достоевского, умело использующего языковые средства для создания особой психологической атмосферы в своем произведении. Перед авторами стоит цель представить каждый образ произведения так, чтобы читатель почувствовал его самостоятельность, независимость его идей от сознания автора и рассказчика. В ходе исследования мы обратились к способам воспроизведения предметного мира в романе «Идиот». Лексические единицы, которые автор использовал для описания интерьеров, сразу дают дополнительную информацию, помогающую формированию образа героя. Для более точной характеристики обстановки писатель берет существительные с уменьшительно-ласкательными суффиксами, созвучные с образом героя лексемы, неопределенные местоимения создают эффект таинственности и загадочности происходящего. Важной особенностью языка произведений Достоевского являются частые намеренные нарушения сочетаемости слов. Каламбуры Достоевского вводятся не только для создания комического эффекта: они служат для создания более глубокого и многогранного изображения того или иного явления. Инверсия формирует особое поэтическое звучание художественного текста произведения. Достоевский не отказывается от включения в текст «Идиота» некоторых популярных и даже клишированных слов и выражений. Преобладание эмоционально-оценочной лексики в художественном мире романа «Идиот» также является характерной чертой его индивидуального художественного стиля.
Activated zinc pyrithione in topical treatment of atopic dermatitis: a case report
Authors: Litovkina Alla O. , Smolnikov Evgeniy V. , Elisyutina Olga G. , Fedenko Elena S.
Published: May 2024

Atopic dermatitis is a systemic multifactorial genetically determined inflammatory skin condition characterized by an impairment of the epidermal barrier and Type 2 inflammation. Atopic dermatitis is highly prevalent, especially among children. Many authors consider atopic dermatitis as the initial stage of the atopic march, which typically manifests in the first year of life. Topical agents such as topical glucocorticosteroids and topical calcineurin inhibitors are the first-line treatments for atopic dermatitis. In recent years, there has been an increasing use of modern systemic anti-inflammatory agents, such as monoclonal antibodies and Janus kinase inhibitors.
Therapy of patients with atopic dermatitis is aimed at relieving itching, improving skin barrier function, reducing inflammation, preventing skin infection and exacerbations. The effectiveness of treatment lies not only in improving the symptoms and quality of life of patients with atopic dermatitis, but also in preventing them from developing chronic or severe symptoms.
Modern topical glucocorticosteroids and their combinations, have a proven high safety profile. However, available data on adverse events associated with their use often lead patients and their parents to develop a negative, phobic attitude towards treatment with these drugs. Zinc pyrithione, an activated form of zinc, is a safe and highly effective medication with anti-inflammatory, antifungal, and antibacterial properties.
This article presents two clinical cases of moderate to severe atopic dermatitis in children, demonstrating the effectiveness of using activated zinc pyrithione in comprehensive therapy for this condition.
Automatic Data Extraction Utilizing Structural Similarity From A Set of Portable Document Format (PDF) Files
Authors: Satria Hadipurnawan , Primanita Anggina
Published: May 2024

Instead of storing data in databases, common computer-aided office workers often choose to keep data related to their work in the form of document or report files that they can conveniently and comfortably access with popular off-the-shelf softwares, such as in Portable Document Format (PDF) format files. Their workplaces may actually use databases but they usually do not possess the privilege nor the proficiency to fully utilize them. Said workplaces likely have front-end systems such as Management Information System (MIS) from where workers get their data containing reports or documents.These documents are meant for immediate or presentational uses but workers often keep these files for the data inside which may come to be useful later on. This way, they can manipulate and combine data from one or more report files to suit their work needs, on the occasions that their MIS were not able to fulfill such needs. To do this, workers need to extract data from the report files. However, the files also contain formatting and other contents such as organization banners, signature placeholders, and so on. Extracting data from these files is not easy and workers are often forced to use repeated copy and paste actions to get the data they want. This is not only tedious but also time-consuming and prone to errors. Automatic data extraction is not new, many existing solutions are available but they typically require human guidance to help the data extraction before it can become truly automatic. They may also require certain expertise which can make workers hesitant to use them in the first place. A particular function of an MIS can produce many report files, each containing distinct data, but still structurally similar. If we target all PDF files that come from such same source, in this paper we demonstrated that by exploiting the similarity it is possible to create a fully automatic data extraction system that requires no human guidance. First, a model is generated by analyzing a small sample of PDFs and then the model is used to extract data from all PDF files in the set. Our experiments show that the system can quickly achieve 100% accuracy rate with very few sample files. Though there are occasions where data inside all the PDFs are not sufficiently distinct from each other resulting in lower than 100% accuracy, this can be easily detected and fixed with slight human intervention. In these cases, total no human intervention may not be possible but the amount needed can be significantly reduced.