bluuebunny/crossref_metadata_2025 huggingface dataset:
Position-Specific Attentional Skills in Team Sports: A Comparison between Defensive and Offensive Football Players
Authors: Klatt Stefanie , Nerb Josef
Published: June 2021

Over the last few decades, technical as well as cognitive skills and their relation to position-specific skill requirements have been extensively investigated as indicators for players’ performance in team sports. To explore the impact of positioning in football on inattentional blindness we employed dynamic tasks that presented an unexpected object and analyzed its noticing rates in three different experiments. In Experiment 1, amateur and expert football players performed a well-established inattentional blindness task of counting the number of times a basketball was passed between two groups while an unexpected, non-sport specific object was introduced to the situation. Noticing rates were higher for strikers compared to players of other playing positions. The findings support a position-specific advantage regarding inattentional blindness for more offensive players compared to more defensive players. Using the same inattentional blindness task, this finding was investigated in Experiment 2 in more detail, i.e., by differentiating between more playing positions. Results revealed that offensive players (in particular strikers) observed unexpected objects more frequently than defensive players. Experiment 3 used a newly developed football-specific task requiring participants to find solutions in different game situations with an unexpected free-standing player appearing in one of these situations. Defensive players again showed more inattentional blindness than offensive players (in particular offensive mid-fielders), i.e., offensive players perceived the unmarked player more often. This indicates that players not only differ in the conscious perception of unexpected objects that are irrelevant to the sport as a function of their playing position, but also show differences when the perception of the unexpected relevant object is useful for finding tactical solutions in a given game situation. Our findings provide further insight into the importance of the definition of position-specific skill requirements in team sports.
Research on Performance Evaluation and Optimization Theory for Thermal Microscope Imaging Systems
Authors: Zhang Bozhi , Gao Meijing , Rosin Paul L. , Sun Xianfang , Chang Qiuyue , Yan Qichong , Shang Yucheng
Published: June 2021

Infrared imaging theory is an important theoretical basis for the design of infrared imaging systems, but there is no research on infrared imaging theory for designing thermal microscope imaging systems. Therefore, we studied the performance evaluation and optimization theory of thermal microscope imaging systems. In this paper, we analyzed the difference in spectral radiant flux between thermal microscope imaging and telephoto thermal imaging. The expression of signal-to-noise ratio of the output image of the thermal microscope imaging systems was derived, based on the analysis of the characteristics of thermal microscope imaging. We studied the performance evaluation model of thermal microscope imaging systems based on the minimum resolvable temperature difference and the minimum detectable temperature difference. Simulation and analysis of different detectors (ideal photon detector and ideal thermal detector) were also carried out. Finally, based on the conclusion of theoretical research, we carried out a system design and image acquisition experiment. The results show that the theoretical study of thermal microscope imaging systems in this paper can provide reference for the performance evaluation and optimization of thermal microscope imaging systems.
Experimental Evaluation of Connectors Performance for Modular Double-Skinned Composite Tubular Wind Turbine Tower
Authors: Kim Sungwon , Hong Hyemin , Han Taek Hee
Published: June 2021

Three types of connectors were proposed and tested for a modular double-skinned composite tubular (DSCT) wind turbine tower, which is composed of two concentric steel tubes filled with concrete between them. The three proposed types were a socket type connector, an H-type connector, and a bolted–welded with shear key connector. Using the proposed connectors, three modular DSCT tower specimens and a single-body specimen were built. Then, quasi-static tests were conducted to evaluate the performance of the three types of connectors, and their behavioral characteristics and failure modes were analyzed. The test results showed that the bolted–welded with shear key connector specimen exerted an almost equal moment resisting capacity as the single-body specimen; however, the other modular specimens exerted only half the moment resisting capacity of the single-body specimen. Moreover, the results showed that the bolted–welded with shear key connector is applicable in a modular DSCT wind turbine tower as it has equal ductility, maximum lateral displacement, and energy dissipation as the single-body specimen.
Evaluation of Morphological Changes in Grapes Coated with a Biosurfactant Extract Obtained from Corn Steep Liquor
Authors: Martínez-Arcos Andrea , López-Prieto Alejandro , Rodríguez-López Lorena , Pérez-Cid Benita , Vecino Xanel , Moldes Ana Belén , Cruz José Manuel
Published: June 2021

In this work, grapes were coated with a multifunctional biosurfactant extract obtained from corn steep liquor after liquid–liquid extraction with ethyl acetate. This biosurfactant extract has been demonstrated to not only possess a surfactant capacity but also antimicrobial activity. Hence, it could be an excellent preservative for fruits, as it is more biodegradable and more biocompatible than chemically synthetized preservatives. However, before applying this biosurfactant as a preservative on fruits, it is necessary to study the changes in the surface properties of fruits produced by the addition of this bioactive compound. Therefore, in this work, grapes coated with an aqueous solution containing 1 g/L of the biosurfactant extract were subjected to surface analysis using non-invasive technologies, including profilometry. 2D digital photographs of the surface and parametric roughness of grapes were obtained. They revealed that the biosurfactant extract decreased the roughness of the grape surface compared with non-coated grapes and reduced the changes in the shape of the grapes over time. Moreover, it was observed that the biosurfactant extract increased the hydrophobicity of the grape surface observing higher contact angle compared with non-coated grapes.
Heat Transfer Correlations for Star-Shaped Fins
Authors: Bošnjaković Mladen , Čikić Ante , Muhič Simon , Holik Mario
Published: June 2021

Star-shaped fins are a newer type of fin for which correlations for heat transfer and pressure drop do not yet exist in the literature. Therefore, correlation equations for air-side heat transfer and pressure drop in a finned heat exchanger with star-shaped stainless-steel fins in staggered arrangement were developed in this work. To obtain these correlations, a numerical analysis of the basic heat exchanger geometry and another 21 variants of heat exchanger geometry was performed using computational fluid dynamics, and then the results of laboratory tests of a model of heat exchangers with star-shaped fins were used. In the numerical analysis, the fin pitch, the fin thickness, and the air velocity at the inlet to the heat exchanger were varied. The Nusselt (Nu) and Euler (Eu) numbers were determined for each variation analyzed. Initial correlations for Nu and Eu were derived using the least-squares deviation method. The correlation coefficients thus obtained were adjusted to agree with the results of the laboratory tests. The deviation of the final obtained correlation for Nu from the experimental test results was up to 10% in the range of Re < 3500, whereas for higher values of Re, the deviation was less than 2%. The Eu correlation deviated from experimental results up to 19% in the range of Re < 4000, whereas in the range of Re > 5600, the deviation was less than 1%. The correlations were valid in the range 2000 < Re < 16,000.
Design and Application of Simulating Cutting Experiment System for Drum Shearer
Authors: Peng Tianhao , Li Changpeng , Zhu Yanmin
Published: June 2021

When the shearer cuts coal or rock with different hardness, it will produce corresponding cutting state information. This paper develops a simulation cutting experiment system for the drum shearer based on similarity theory. It took the spiral cutting drum of a shearer as the research target and derived the principal similarity coefficients through the dimensional analysis method. Meanwhile, this paper designed the structure of the cutting power system and hydraulic system. Then, it chose a certain amount of coal powder as an aggregate, cement 325# as cementing material, sand, and water as auxiliary materials to prepare simulated coal samples. The paper adopted the orthogonal experiment method and used a proportion of cement, sand, and water as the influencing factors in designing a simulated coal sample preparation plan. In addition, it utilized the range analysis method to research the influence of various factors on the density and compressive strength of simulated coal samples. Finally, it conducted simulated coal sample cutting tests. The results show that the density of the simulated coal samples is between 1192.59 Kg/m3–1483.51 Kg/m3, and the compressive strength range reaches 0.16 MPa–3.94 MPa. The density of the simulated coal sample is related to the mass proportion of cement and sand. When the ratio gradually increases, the influence of sand increases. Furthermore, the compressive strength is linearly proportional to the proportion of cement. The self-designed simulation cutting experiment system could effectively carry out the relevant experiments and obtain the corresponding cutting condition signals through the sensors. There are differences in vibration signals generated by cutting different strength materials. Extracting the kurtosis value as the characteristic value can distinguish various cutting modes, which can provide a reliable experimental solution for the research of coal-rock identification.
A Study on the Analysis of the Effects of Passenger Ship Abandonment Training Using VR
Authors: Chae Chong-Ju , Kim Daegun , Lee Hyeong-Tak
Published: June 2021

Virtual reality (VR) has been adopted for education and training in numerous lines of work. In the field of maritime education and training (MET), training with VR has been implemented in areas such as engine room system familiarization, dangerous work onboard familiarization, and emergency response. In addition, in line with current trends in maritime autonomous surface ship (MASS) technology developments, trial applications of VR have been implemented to understand the applicability of this type of vessel. Moreover, there is an increasing need to reinforce education/training in MET to reduce ship accidents. The purpose of this study is to investigate the level of satisfaction with VR education/training, the impact of that education, and matters requiring training emphasis for implementation. To this end, the training participants’ satisfaction with VR training was compared to that of video training, and items of strategic importance in the training content were identified using Borich’s needs assessment, after which the educational impact of VR training was compared to that of video training. The results of this study are expected to contribute to the extended application of MET using VR, and can help in identifying areas for emphasis in training to reduce maritime accidents.
Multi-Objective Optimisation of Tyre and Suspension Parameters during Cornering for Different Road Roughness Profiles
Authors: Papaioannou Georgios , Jerrelind Jenny , Drugge Lars
Published: June 2021

Effective emission control technologies and novel propulsion systems have been developed for road vehicles, decreasing exhaust particle emissions. However, work has to be done on non-exhaust traffic related sources such as tyre–road interaction and tyre wear. Given that both are inevitable in road vehicles, efforts for assessing and minimising tyre wear should be considered. The amount of tyre wear is because of internal (tyre structure, manufacturing, etc.) and external (suspension configuration, speed, road surface, etc.) factors. In this work, the emphasis is on the optimisation of such parameters for minimising tyre wear, but also enhancing occupant’s comfort and improving vehicle handling. In addition to the search for the optimum parameters, the optimisation is also used as a tool to identify and highlight potential trade-offs between the objectives and the various design parameters. Hence, initially, the tyre design (based on some chosen tyre parameters) is optimised with regards to the above-mentioned objectives, for a vehicle while cornering over both Class A and B road roughness profiles. Afterwards, an optimal solution is sought between the Pareto alternatives provided by the two road cases, in order for the tyre wear levels to be less affected under different road profiles. Therefore, it is required that the tyre parameters are as close possible and that they provide similar tyre wear in both road cases. Then, the identified tyre design is adopted and the optimum suspension design is sought for the two road cases for both passive and semi-active suspension types. From the results, significant conclusions regarding how tyre wear behaves with regards to passenger comfort and vehicle handling are extracted, while the results illustrate where the optimum suspension and tyre parameters have converged trying to compromise among the above objectives under different road types and how suspension types, passive and semi-active, could compromise among all of them more optimally.
Nash Equilibrium Sequence in a Singular Two-Person Linear-Quadratic Differential Game
Authors: Glizer Valery Y.
Published: June 2021

A finite-horizon two-person non-zero-sum differential game is considered. The dynamics of the game is linear. Each of the players has a quadratic functional on its own disposal, which should be minimized. The case where weight matrices in control costs of one player are singular in both functionals is studied. Hence, the game under the consideration is singular. A novel definition of the Nash equilibrium in this game (a Nash equilibrium sequence) is proposed. The game is solved by application of the regularization method. This method yields a new differential game, which is a regular Nash equilibrium game. Moreover, the new game is a partial cheap control game. An asymptotic analysis of this game is carried out. Based on this analysis, the Nash equilibrium sequence of the pairs of the players’ state-feedback controls in the singular game is constructed. The expressions for the optimal values of the functionals in the singular game are obtained. Illustrative examples are presented.
Histone H3K4 Methyltransferases as Targets for Drug-Resistant Cancers
Authors: Yang Liu , Jin Mingli , Jeong Kwang Won
Published: June 2021

The KMT2 (MLL) family of proteins, including the major histone H3K4 methyltransferase found in mammals, exists as large complexes with common subunit proteins and exhibits enzymatic activity. SMYD, another H3K4 methyltransferase, and SET7/9 proteins catalyze the methylation of several non-histone targets, in addition to histone H3K4 residues. Despite these structural and functional commonalities, H3K4 methyltransferase proteins have specificity for their target genes and play a role in the development of various cancers as well as in drug resistance. In this review, we examine the overall role of histone H3K4 methyltransferase in the development of various cancers and in the progression of drug resistance. Compounds that inhibit protein–protein interactions between KMT2 family proteins and their common subunits or the activity of SMYD and SET7/9 are continuously being developed for the treatment of acute leukemia, triple-negative breast cancer, and castration-resistant prostate cancer. These H3K4 methyltransferase inhibitors, either alone or in combination with other drugs, are expected to play a role in overcoming drug resistance in leukemia and various solid cancers.
CIRCNV: Detection of CNVs Based on a Circular Profile of Read Depth from Sequencing Data
Authors: Zhao Hai-Yong , Li Qi , Tian Ye , Chen Yue-Hui , Alvi Haque A. K. , Yuan Xi-Guo
Published: June 2021

Copy number variation (CNV) is a common type of structural variation in the human genome. Accurate detection of CNVs from tumor genomes can provide crucial information for the study of tumor genesis and cancer precision diagnosis. However, the contamination of normal genomes in tumor genomes and the crude profiles of the read depth make such a task difficult. In this paper, we propose an alternative approach, called CIRCNV, for the detection of CNVs from sequencing data. CIRCNV is an extension of our previously developed method CNV-LOF, which uses local outlier factors to predict CNVs. Comparatively, CIRCNV can be performed on individual tumor samples and has the following two new features: (1) it transfers the read depth profile from a line shape to a circular shape via a polar coordinate transformation, in order to improve the efficiency of the read depth (RD) profile for the detection of CNVs; and (2) it performs a second round of CNV declaration based on the truth circular RD profile, which is recovered by estimating tumor purity. We test and validate the performance of CIRCNV based on simulation and real sequencing data and perform comparisons with several peer methods. The results demonstrate that CIRCNV can obtain superior performance in terms of sensitivity and precision. We expect that our proposed method will be a supplement to existing methods and become a routine tool in the field of variation analysis of tumor genomes.
Ratiometric Fluorescent Biosensors for Glucose and Lactate Using an Oxygen-Sensing Membrane
Authors: Duong Hong Dinh , Rhee Jong Il
Published: June 2021

In this study, ratiometric fluorescent glucose and lactate biosensors were developed using a ratiometric fluorescent oxygen-sensing membrane immobilized with glucose oxidase (GOD) or lactate oxidase (LOX). Herein, the ratiometric fluorescent oxygen-sensing membrane was fabricated with the ratio of two emission wavelengths of platinum meso-tetra (pentafluorophenyl) porphyrin (PtP) doped in polystyrene particles and coumarin 6 (C6) captured into silica particles. The operation mechanism of the sensing membranes was based on (i) the fluorescence quenching effect of the PtP dye by oxygen molecules, and (ii) the consumption of oxygen levels in the glucose or lactate oxidation reactions under the catalysis of GOD or LOX. The ratiometric fluorescent glucose-sensing membrane showed high sensitivity to glucose in the range of 0.1–2 mM, with a limit of detection (LOD) of 0.031 mM, whereas the ratiometric fluorescent lactate-sensing membrane showed the linear detection range of 0.1–0.8 mM, with an LOD of 0.06 mM. These sensing membranes also showed good selectivity, fast reversibility, and stability over long-term use. They were applied to detect glucose and lactate in artificial human serum, and they provided reliable measurement results.
Do Advanced Spatial Strategies Depend on the Number of Flight Hours? The Case of Military Pilots
Authors: Giancola Marco , Verde Paola , Cacciapuoti Luigi , Angelino Gregorio , Piccardi Laura , Bocchi Alessia , Palmiero Massimiliano , Nori Raffaella
Published: June 2021

Background: Military pilots show advanced visuospatial skills. Previous studies demonstrate that they are better at mentally rotating a target, taking different perspectives, estimating distances and planning travel and have a topographic memory. Here, we compared navigational cognitive styles between military pilots and people without flight experience. Pilots were expected to be more survey-style users than nonpilots, showing more advanced navigational strategies. Method: A total of 106 military jet pilots from the Italian Air Force and 92 nonpilots from the general population matched for education with the pilots were enrolled to investigate group differences in navigational styles. The participants were asked to perform a reduced version of the Spatial Cognitive Style Test (SCST), consisting of six tasks that allow us to distinguish individuals in terms of landmark (people orient themselves by using a figurative memory for environmental objects), route (people use an egocentric representation of the space) and survey (people have a map-like representation of the space) user styles. Results: In line with our hypothesis, military pilots mainly adopt the survey style, whereas nonpilots mainly adopt the route style. In addition, pilots outperformed nonpilots in both the 3D Rotation Task and Map Description Task. Conclusions: Military flight expertise influences some aspects of spatial ability, leading to enhanced human navigation. However, it must be considered that they are a population whose navigational skills were already high at the time of selection at the academy before formal training began.
Innovative Use of Low-Cost Digitisation for Smart Information Systems in Construction Projects
Authors: Babaeian Jelodar Mostafa , Shu Feiya
Published: June 2021

The low-level application of digital tools and information systems in construction implies that many projects cannot meet modern requirements and standard of work of advanced industries. This study adopts a practical and diagnostic approach to identify key attributes and implementation processes of information systems in construction and logistics. To have triangulation of knowledge, a three-step methodology is adopted. Initially an exploratory analysis of previous literature is performed. Secondly a diagnostic analysis of IS applications in construction is achieved by case studies. Finally, expert interviews are performed to examine and consolidate the findings. The study illustrated practical and innovative applications of low-cost digital tools in IS development and created a framework for documentation of these discrete and mostly unshared practices. It is recommended that the construction sector should embrace more advance technologies to minimise human intervention and enhance real-time capabilities. The practicality of how different low-cost and off-the-shelf tools and digital platforms can be combined is discussed and demonstrated. The study provides a clear distinction for practitioners and academics as to what is being practiced in comparison to the dominant theories.
The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study
Authors: Doello Kevin , Mesas Cristina , Quiñonero Francisco , Perazzoli Gloria , Cabeza Laura , Prados Jose , Melguizo Consolacion , Ortiz Raul
Published: June 2021

Sodium selenite acts by depleting enzymes that protect against cellular oxidative stress. To determine its effect alone or in combination with gemcitabine (GMZ) in pancreatic cancer, we used PANC-1 and Pan02 cell lines and C57BL mice bearing a Pan02-generated tumor. Our results demonstrated a significant inhibition of pancreatic cancer cell viability with the use of sodium selenite alone and a synergistic effect when associated with GMZ. The molecular mechanisms of the antitumor effect of sodium selenite alone involved apoptosis-inducing factor (AIF) and the expression of phospho-p38 in the combined therapy. In addition, sodium selenite alone and in association with GMZ significantly decreased the migration capacity and colony-forming ability, reduced tumor activity in multicellular tumor spheroids (MTS) and decreased sphere formation of cancer stem cells. In vivo studies demonstrated that combined therapy not only inhibited tumor growth (65%) compared to the untreated group but also relative to sodium selenite or GMZ used as monotherapy (up to 40%), increasing mice survival. These results were supported by the analysis of C57BL/6 albino mice bearing a Pan02-generated tumor, using the IVIS system. In conclusion, our results showed that sodium selenite is a potential agent for the improvement in the treatment of pancreatic cancer and should be considered for future human clinical trials.
Eradication of Measurable Residual Disease in AML: A Challenging Clinical Goal
Authors: Bernasconi Paolo , Borsani Oscar
Published: June 2021

In non-promyelocytic (non-M3) AML measurable residual disease (MRD) detected by multi-parameter flow cytometry and molecular technologies, which are guided by Consensus-based guidelines and discover very low leukemic cell numbers far below the 5% threshold of morphological assessment, has emerged as the most relevant predictor of clinical outcome. Currently, it is well-established that MRD positivity after standard induction and consolidation chemotherapy, as well as during the period preceding an allogeneic hematopoietic stem cell transplant (allo-HSCT), portends to a significantly inferior relapse-free survival (RFS) and overall survival (OS). In addition, it has become absolutely clear that conversion from an MRD-positive to an MRD-negative state provides a favorable clinical outcome similar to that associated with early MRD negativity. Thus, the complete eradication of MRD, i.e., the clearance of the few leukemic stem cells—which, due to their chemo-radiotherapy resistance, might eventually be responsible of disease recurrence—has become an un-met clinical need in AML. Nowadays, this goal might potentially be achieved thanks to the development of novel innovative treatment strategies, including those targeting driver mutations, apoptosis, methylation patterns and leukemic proteins. The aim of this review is to analyze these strategies and to suggest any potential combination able to induce MRD negativity in the pre- and post-HSCT period.
Establishment of a Novel In Vitro Model of Endometriosis with Oncogenic KRAS and PIK3CA Mutations for Understanding the Underlying Biology and Molecular Pathogenesis
Authors: Hossain Mohammad Mahmud , Nakayama Kentaro , Shanta Kamrunnahar , Razia Sultana , Ishikawa Masako , Ishibashi Tomoka , Yamashita Hitomi , Sato Seiya , Iida Kouji , Kanno Kosuke , Ishikawa Noriyoshi , Kiyono Tohru , Kyo Satoru
Published: June 2021

Endometriosis-harboring cancer-associated somatic mutations of PIK3CA and KRAS provides new opportunities for studying the multistep processes responsible for the functional and molecular changes in this disease. We aimed to establish a novel in vitro endometriosis model to clarify the functional behavior and molecular pathogenesis of this disorder. Immortalized HMOsisEC10 human ovarian endometriotic epithelial cell line was used in which KRAS and PIK3CA mutations were introduced. Migration, invasion, proliferation, and microarray analyses were performed using KRAS and PIK3CA mutant cell lines. In vitro assays showed that migration, invasion, and proliferation were significantly increased in KRAS and PIK3CA mutant cell lines, indicating that these mutations played causative roles in the aggressive behavior of endometriosis. Microarray analysis identified a cluster of gene signatures; among them, two significantly upregulated cancer-related genes, lysyl oxidase (LOX) and pentraxin3 (PTX3), were associated with cell proliferation, invasion, and migration capabilities. Furthermore, siRNA knockdown of the two genes markedly reduced the metastatic ability of the cells. These results suggest that endometriosis with KRAS or PIK3CA mutations can significantly enhance cell migration, invasion, and proliferation by upregulating LOX and PTX3. We propose that LOX and PTX3 silencing using small molecules could be an alternative therapeutic regimen for severe endometriosis.
Next-Generation Molecular Imaging of Thyroid Cancer
Authors: Jin Yuchen , Liu Beibei , Younis Muhsin H. , Huang Gang , Liu Jianjun , Cai Weibo , Wei Weijun
Published: June 2021

An essential aspect of thyroid cancer (TC) management is personalized and precision medicine. Functional imaging of TC with radioiodine and [18F]FDG has been frequently used in disease evaluation for several decades now. Recently, advances in molecular imaging have led to the development of novel tracers based on aptamer, peptide, antibody, nanobody, antibody fragment, and nanoparticle platforms. The emerging targets—including HER2, CD54, SHP2, CD33, and more—are promising targets for clinical translation soon. The significance of these tracers may be realized by outlining the way they support the management of TC. The provided examples focus on where preclinical investigations can be translated. Furthermore, advances in the molecular imaging of TC may inspire the development of novel therapeutic or theranostic tracers. In this review, we summarize TC-targeting probes which include transporter-based and immuno-based imaging moieties. We summarize the most recent evidence in this field and outline how these emerging strategies may potentially optimize clinical practice.
Selective Oxidation of Isobutane to Methacrylic Acid and Methacrolein: A Critical Review
Authors: Zhang Li , Paul Sébastien , Dumeignil Franck , Katryniok Benjamin
Published: June 2021

Selective oxidation of isobutane to methacrolein (MAC) and methacrylic acid (MAA) has received great interest both in the chemical industry and in academic research. The advantages of this reaction originate not only from the low cost of the starting material and reduced process complexity, but also from limiting the use of toxic reactants and the production of wastes. Successive studies and reports have shown that heteropolycompounds (HPCs) with Keggin structure (under the form of partially neutralized acids with increased stability) can selectively convert isobutane to MAA and MAC due to their strong and tunable acidity and redox properties. This review hence aims to discuss the Keggin-type HPCs that have been used in recent years to catalyze the oxidation of isobutane to MAA and MAC, and to review alternative metal oxides with proper redox properties for the same reaction. In addition, the influence of the main reaction conditions will be discussed.
Massive Gastric Hemorrhage after Indomethacin Therapy: A Rare Presentation and Critical Management in an Extremely Preterm Infant
Authors: Chen Yen-Ju , Chu Wei-Ying , Yu Wen-Hao , Chen Chau-Jing , Chia Shu-Ti , Wang Jieh-Neng , Lin Yung-Chieh , Wei Yu-Jen
Published: June 2021

Indomethacin has been widely used in preterm infants with hemodynamically significant patent ductus arteriosus (PDA). Gastrointestinal complications of indomethacin have been reported in 5% of treated neonates. However, massive gastric mucosa hemorrhage is a rarely reported complication. To the best of our knowledge, the infant in this report is the smallest reported in the literature to have undergone successful surgery for such a complication. A male preterm infant weighing 566 g was born at 252/7 weeks of gestational age without a complicated maternal history. Soon after birth, he received nasal noninvasive respiratory support and minimal feeding. PDA was observed since the first day of life (DOL), treatments were initiated on the second DOL for the hemodynamical significance, and PDA was closed after two courses of indomethacin therapy (0.2 mg/kg). At midnight on the seventh DOL, generalized pallor, bloody gastric drainage, and a distended stomach were observed. Massive gastric bleeding was suspected. He suffered from intermittent hypotension, which was corrected with blood products and fluid resuscitation under monitoring with a radial arterial line. Gastric lavage with cooling saline was performed twice but in vain. Prior to surgical consultation, intravascular volume transfusion was given twice. An exploratory laparotomy was arranged after obtaining the parents’ consent. Blood oozing from the gastric mucosa was observed through gastrostomy and was successfully stopped via epinephrine-soaked gauze compression. After the operation, his clinical course remained uneventful, and he was discharged without neurological anomaly at two-year follow-up. Physicians need to be cautious of indomethacin’s effect on platelet dysfunction in preterm infants with multiple predisposing factors. The tendency for mucosal bleeding should be continuously monitored after indomethacin therapy.
Sintering/Crystallization and Viscosity of Sealing Glass-Ceramics
Authors: Rodríguez-López Sonia , Pascual Maria
Published: June 2021

Two glass-ceramics sealants for solid-oxide fuel cells (SOFC) in the system BaO/SrO-MgO-B2O3-SiO2 have been analysed according to relevant sealing parameters such as sintering and crystallization of the glass powders and dilatation and viscosity evolution with crystallization of glass-ceramic compacts. Special emphasis is given to the crystallization kinetics and mechanism, crystalline phases formed and the role of viscosity in the whole sealing process. The slower crystallization rate of the strontium-containing glass composition results in good joining with the interconnect steel before the glass starts to crystallize and increases its viscosity. This avoids and excessive sealing temperature and offers better compatibility with the start up and working temperature of an SOFC (750–850 °C).
Specialty Photonic Crystal Fibers and Their Applications
Authors: Novoa David , Joly Nicolas Y.
Published: June 2021

This year not only commemorates the 60th anniversary of nonlinear optics with the seminal experiment of second harmonic generation [...]
Effect of Fly Ash Belite Cement on Hydration Performance of Portland Cement
Authors: Gong Yongfan , Yang Jianming , Sun Haifeng , Xu Fei
Published: June 2021

Fly ash belite cement is a green, low carbon cementitious material, mainly composed of hydraulic minerals of dicalcium silicate and calcium aluminate. In this study, we used fly ash belite cement to control the setting time, hydration heat, strength, composition and microstructure of hydration products in Portland cement. Results showed that incorporating fly ash belite cement into Portland cement can shorten the setting time, accelerate hydration reaction speed, enhance early hydration heat release rate of silicate minerals and reduce total hydration heat. Moreover, replacing composite cement with 30% FABC causes the 90 d compressive strength of pastes and mortars to reach 107 and 46.2 MPa, respectively. The mechanical properties can meet the requirements of P·F 42.5 cement. During the hydration reaction process, clinker and Portland cement have a synergistic hydration effect. Notably, hydration of fly ash belite cement promotes the formation of C-S-H gel, Ettringite and calcium hydroxide, thereby significantly enhancing long-term strength. With the increase of FABC contents, the long-term strength would be improved with the densification of hydration products. The porosity has a great influence on the strength, and the high porosity was the main cause of the low early strength of FABC pastes. FABC and its composite cement show promise for mass concrete applications and can be applied as a setting agent for Portland cement.
The Effect of Genomic DNA Contamination on the Detection of Circulating Long Non-Coding RNAs: The Paradigm of MALAT1
Authors: Markou Athina N. , Smilkou Stavroula , Tsaroucha Emilia , Lianidou Evi
Published: June 2021

The presence of contaminating gDNA in RNA preparations is a frequent cause of false positives in RT-PCR-based analysis. However, in some cases, this cannot be avoided, especially when there are no exons–intron junctions in the lncRNA sequences. Due to the lack of exons in few of long noncoding RNAs (lncRNAs) and the lack of DNAse treatment step in most studies reported so far, serious questions are raised about the specificity of lncRNA detection and the potential of reporting false-positive results. We hypothesized that minute amounts of gDNA usually co-extracted with RNA could give false-positive signals since primers would specifically bind to gDNA due to the lack of junction. In the current study, we evaluated the effect of gDNA and other forms of DNA like extrachromosomal circular DNAs (eccDNAs) contamination and the importance of including a DNAse treatment step on lncRNAsexpression.As a model, we have chosen as one of the most widely studied lncRNAs in cancer namely MALAT1, which lacks exons. When we tested this hypothesis in plasma and primary tissue samples from NSCLC patients, our findings clearly indicated that results on MALAT1 expression are highly affected by the presence of DNA contamination and that the DNAse treatment step is absolutely necessary to avoid false positive results.
NGS Analysis Revealed Digenic Heterozygous GCK and HNF1A Variants in a Child with Mild Hyperglycemia: A Case Report
Authors: Iafusco Fernanda , Maione Giovanna , Mazzaccara Cristina , Di Candia Francesca , Mozzillo Enza , Franzese Adriana , Tinto Nadia
Published: June 2021

Monogenic diabetes (MD) represents a heterogeneous group of disorders whose most frequent form is maturity-onset diabetes of the young (MODY). MD is predominantly caused by a mutation in a single gene. We report a case of a female patient with suspected MD and a positive family history for diabetes and obesity. In this patient, two gene variants have been identified by next-generation sequencing (NGS): one in the Glucokinase (GCK) gene reported in the Human Gene Mutation Database (HGMD) and in the literature associated with GCK/MODY, and the other in the hepatocyte nuclear factor 1A (HNF1A) gene not previously described. The GCK variant was also identified in the hyperglycemic father, whereas the HNF1A variant was present in the mother. This new case of digenic GCK/HNF1A variants identified in a hyperglycemic subject, evidences the importance of NGS analysis in patients with suspected MD. In fact, this methodology will allow us to both increase the number of diagnoses and to identify mutations in more than one gene, with a better understanding of the genetic cause, and the clinical course, of the disease.
A Novel Method to Determine Basic Probability Assignment Based on Adaboost and Its Application in Classification
Authors: Fu Wei , Yu Shuang , Wang Xin
Published: June 2021

In the framework of evidence theory, one of the open and crucial issues is how to determine the basic probability assignment (BPA), which is directly related to whether the decision result is correct. This paper proposes a novel method for obtaining BPA based on Adaboost. The method uses training data to generate multiple strong classifiers for each attribute model, which is used to determine the BPA of the singleton proposition since the weights of classification provide necessary information for fundamental hypotheses. The BPA of the composite proposition is quantified by calculating the area ratio of the singleton proposition’s intersection region. The recursive formula of the area ratio of the intersection region is proposed, which is very useful for computer calculation. Finally, BPAs are combined by Dempster’s rule of combination. Using the proposed method to classify the Iris dataset, the experiment concludes that the total recognition rate is 96.53% and the classification accuracy is 90% when the training percentage is 10%. For the other datasets, the experiment results also show that the proposed method is reasonable and effective, and the proposed method performs well in the case of insufficient samples.
A Data Science Analysis of Academic Staff Workload Profiles in Spanish Universities: Gender Gap Laid Bare
Authors: Cabero Ismael , Epifanio Irene
Published: June 2021

This paper presents a snapshot of the distribution of time that Spanish academic staff spend on different tasks. We carry out a statistical exploratory study by analyzing the responses provided in a survey of 703 Spanish academic staff in order to draw a clear picture of the current situation. This analysis considers many factors, including primarily gender, academic ranks, age, and academic disciplines. The tasks considered are divided into smaller activities, which allows us to discover hidden patterns. Tasks are not only restricted to the academic world, but also relate to domestic chores. We address this problem from a totally new perspective by using machine learning techniques, such as cluster analysis. In order to make important decisions, policymakers must know how academic staff spend their time, especially now that legal modifications are planned for the Spanish university environment. In terms of the time spent on quality of teaching and caring tasks, we expose huge gender gaps. Non-recognized overtime is very frequent.
The Corporate Social Responsibility of Polish Energy Companies
Authors: Stuss Magdalena M. , Makieła Zbigniew J. , Herdan Agnieszka , Kuźniarska Gabriela
Published: June 2021

If corporate social responsibility (CSR) is expected to work efficiently, there should be a standardised approach for implementation of the CSR concept for all businesses, including companies operating in the energy sector. Although many companies declare compliance with CSR standards, further investigation should be undertaken to evaluate if and how those standards have been applied in practice. The aim of this research is to examine the level of standardisation of the CSR activities within Polish energy companies and explore the good practices developed by those companies. The Polish energy companies have been selected for the investigation as the literature review we conducted demonstrates that there is limited research in this area and there is a knowledge gap regarding how Polish energy companies apply CSR regulation in practice. To accomplish the stated aims, the following research questions were developed: (1) What is the essence of applying the CSR concept in Polish energy companies, and at what level of development is the concept applied? (2) To what extent do Polish energy companies have a common approach to the CSR concept, and in what areas are there differences? (3) To what extent have Polish energy companies applied global CSR standards and solutions? (4) Is there a gap between the declared measures of CSR and their actual implementation in Polish energy companies? The research methodology of this study is based on a systematic literature review of the sources acquired from databases such as ProQuest, Emerald, SCOPUS and the Jagiellonian University Library. The multiple case study approach was identified as the most suitable research tool. Companies for the study were selected according to their affiliation to the energy sector and listing on the main market of the Warsaw Stock Exchange. These two assumptions allowed us to base this study on the largest Polish energy companies that have international status. Six areas of CSR annual report disclosures have been identified and used for the investigation and analysis. This research looks at similarities and difference between these six aspects of CSRs disclosed by Polish energy companies. The investigation allows us to conclude that the top three energy companies use similar tools to build their CSR strategies: formalised CSR concept, published CSR reports, disclosure of CSR information on the company website, CSR related activities offered to stakeholders, obtained CSR certificates, and CSR awards. This indicates the existence of a standardised approach to CSR across Polish energy companies.
Proposal for an Integrated Framework for Electronic Control Unit Design in the Automotive Industry
Authors: Buczacki Aleksander , Piątek Piotr
Published: June 2021

The automotive sector is facing challenges in terms of the requirements for guaranteeing the safety and security of cars. In respect of the engineering process, it is challenging to incorporate functional safety, safety of the intended functionality, and cybersecurity requirements into electrical vehicles. All of these aspects impact not only the vehicles or ECUs produced, but also the structures of the organizations by which the products are created. Based on current standards, drafts of future standards, and an analysis of the performance of a real design process for the ECU of an electrical vehicle, we propose an integrated design framework from the perspective of cybersecurity. Therefore, a stronger emphasis is placed on correct estimations of cybersecurity activity processes. As they affect all areas of development, these estimations cannot be isolated considering the ECU’s design process. More cooperation between various stages of the process is required in order to provide complete products at an early stage of design and development. The challenge is the identification of overlapping activities and the combination of design efforts in order to reduce the time and costs of an engineering project. A dedicated process entity will be proposed to an engineering division to manage cybersecurity processes.
Applying Harmonised Geothermal Life Cycle Assessment Guidelines to the Rittershoffen Geothermal Heat Plant
Authors: Douziech Mélanie , Tosti Lorenzo , Ferrara Nicola , Parisi Maria Laura , Pérez-López Paula , Ravier Guillaume
Published: June 2021

Heat production from a geothermal energy source is gaining increasing attention due to its potential contribution to the decarbonization of the European energy sector. Obtaining representative results of the environmental performances of geothermal systems and comparing them with other renewables is of utmost importance in order to ensure an effective energy transition as targeted by Europe. This work presents the outputs of a Life Cycle Assessment (LCA) performed on the Rittershoffen geothermal heat plant applying guidelines that were developed within the H2020 GEOENVI project. The production of 1 kWhth from the Rittershoffen heat plant was compared to the heat produced from natural gas in Europe. Geothermal heat production performed better than the average heat production in climate change and resource use, fossil categories. The LCA identified the electricity consumption during the operation and maintenance phase as a hot spot for several impact categories. A prospective scenario analysis was therefore performed to assess the evolution of the environmental performances of the Rittershoffen heat plant associated with the future French electricity mixes. The increase of renewable energy shares in the future French electricity mix caused the impact on specific categories (e.g., land use and mineral and metals resource depletion) to grow over the years. However, an overall reduction of the environmental impacts of the Rittershoffen heat plant was observed.
Estimation of Frequency-Dependent Impedances in Power Grids by Deep LSTM Autoencoder and Random Forest
Authors: Bagheri Azam , Bongiorno Massimo , Gu Irene Y. H. , Svensson Jan R.
Published: June 2021

This paper proposes a deep-learning-based method for frequency-dependent grid impedance estimation. Through measurement of voltages and currents at a specific system bus, the estimate of the grid impedance was obtained by first extracting the sequences of the time-dependent features for the measured data using a long short-term memory autoencoder (LSTM-AE) followed by a random forest (RF) regression method to find the nonlinear map function between extracted features and the corresponding grid impedance for a wide range of frequencies. The method was trained via simulation by using time-series measurements (i.e., voltage and current) for different system parameters and verified through several case studies. The obtained results show that: (1) extracting the time-dependent features of the voltage/current data improves the performance of the RF regression method; (2) the RF regression method is robust and allows grid impedance estimation within 1.5 grid cycles; (3) the proposed method can effectively estimate the grid impedance both in steady state and in case of large transients like electrical faults.