bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptional and Translational Dynamics of Zika and Dengue Virus Infection
Authors: Singh Kamini , Martinez Maria Guadalupe , Lin Jianan , Gregory James , Nguyen Trang Uyen , Abdelaal Rawan , Kang Kristy , Brennand Kristen , Grünweller Arnold , Ouyang Zhengqing , Phatnani Hemali , Kielian Margaret , Wendel Hans-Guido
Published: June 2022

Zika virus (ZIKV) and dengue virus (DENV) are members of the Flaviviridae family of RNA viruses and cause severe disease in humans. ZIKV and DENV share over 90% of their genome sequences, however, the clinical features of Zika and dengue infections are very different reflecting tropism and cellular effects. Here, we used simultaneous RNA sequencing and ribosome footprinting to define the transcriptional and translational dynamics of ZIKV and DENV infection in human neuronal progenitor cells (hNPCs). The gene expression data showed induction of aminoacyl tRNA synthetases (ARS) and the translation activating PIM1 kinase, indicating an increase in RNA translation capacity. The data also reveal activation of different cell stress responses, with ZIKV triggering a BACH1/2 redox program, and DENV activating the ATF/CHOP endoplasmic reticulum (ER) stress program. The RNA translation data highlight activation of polyamine metabolism through changes in key enzymes and their regulators. This pathway is needed for eIF5A hypusination and has been implicated in viral translation and replication. Concerning the viral RNA genomes, ribosome occupancy readily identified highly translated open reading frames and a novel upstream ORF (uORF) in the DENV genome. Together, our data highlight both the cellular stress response and the activation of RNA translation and polyamine metabolism during DENV and ZIKV infection.
Epidemic and Evolutionary Characteristics of Swine Enteric Viruses in South-Central China from 2018 to 2021
Authors: Li Chang , Lu Hongyu , Geng Chao , Yang Keli , Liu Wei , Liu Zewen , Yuan Fangyan , Gao Ting , Wang Shuangshuang , Wen Ping , Song Haofei , Tian Yongxiang , Zhou Danna
Published: June 2022

Swine enteric viruses are a major cause of piglet diarrhea, causing a devastating impact on the pork industry. To further understand the molecular epidemiology and evolutionary diversity of swine enteric viruses, we carried out a molecular epidemiological investigation of swine enteric viruses (PEDV, PDCoV, PoRVA, and TGEV) on 7107 samples collected from pig farms in south-central China. The results demonstrated that PEDV is the predominant pathogen causing piglet diarrhea, and its infection occurs mainly in relatively cold winter and spring in Hunan and Hubei provinces. The positive rate of PEDV showed an abnormal increase from 2020 to 2021, and that of PoRVA and PDCoV exhibited gradual increases from 2018 to 2021. PEDV-PoRVA and PEDV-PDCoV were the dominant co-infection modes. A genetic evolution analysis based on the PEDV S1 gene and ORF3 gene revealed that the PEDV GII-a is currently epidemic genotype, and the ORF3 gene of DY2020 belongs to a different clade relative to other GII-a strains isolated in this study. Overall, our results indicated that the variant PEDV GII-a is the main pathogen of piglet diarrhea with a trend of outbreak. G9 is the dominant PoRVA genotype and has the possibility of outbreak as well. It is therefore critical to strengthen the surveillance of PEDV and PoRVA, and to provide technical reserves for the prevention and control of piglet diarrhea.
Pathophysiology of Influenza D Virus Infection in Specific-Pathogen-Free Lambs with or without Prior Mycoplasma ovipneumoniae Exposure
Authors: Robinson Ema , Schulein Clyde , Jacobson B. Tegner , Jones Kerri , Sago Jonathon , Huber Victor , Jutila Mark , Bimczok Diane , Rynda-Apple Agnieszka
Published: June 2022

Polymicrobial pneumonias occur frequently in cattle, swine, and sheep, resulting in major economic losses. Individual pathogens comprising these complex infections may be mild on their own but can instead exhibit synergism or increase host susceptibility. Two examples of such pathogens, Mycoplasma ovipneumoniae (M. ovipneumoniae) and influenza D viruses (IDVs), naturally infect domestic sheep. In sheep, the role of M. ovipneumoniae in chronic nonprogressive pneumonia is well-established, but the pathogenesis of IDV infection has not previously been studied. We utilized a specific-pathogen-free sheep flock to study the clinical response to IDV infection in naïve vs. M. ovipneumoniae-exposed lambs. Lambs were inoculated intranasally with M. ovipneumoniae or mock infection, followed after four weeks by infection with IDV. Pathogen shedding was tracked, and immunological responses were evaluated by measuring acute phase response and IDV-neutralizing antibody titers. While lamb health statuses remained subclinical, M. ovipneumoniae-exposed lambs had significantly elevated body temperatures during IDV infection compared to M. ovipneumoniae-naïve, IDV-infected lambs. Moreover, we found a positive correlation between prior M. ovipneumoniae burden, early-infection IDV shedding, and IDV-neutralizing antibody response. Our findings suggest that IDV infection may not induce clinical symptoms in domestic sheep, but previous M. ovipneumoniae exposure may promote mild IDV-associated inflammation.
Cytokine and Lymphocyte Profiles in Dogs with Atopic Dermatitis after Allergen-Specific Immunotherapy
Authors: Majewska Alicja , Dembele Kourou , Dziendzikowska Katarzyna , Prostek Adam , Gajewska Małgorzata
Published: June 2022

Canine atopic dermatitis (cAD) is a chronic and recurrent inflammatory and pruritic skin disease in dogs. Currently, allergen-specific immunotherapy (ASIT) is the only identified disease-modifying intervention for allergic diseases. It decreases the symptoms triggered by allergens and prevents recurrence of the disease in the long-term. The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. ASIT was applied for 6 months. Blood samples for further analyses were collected from patients in the third and sixth month of immunotherapy. Six out of seven dogs receiving ASIT showed a positive effect. A reduction in cytokine levels (IL-13, TNF-α) in peripheral blood of cAD patients and changes in the number of specific T cell subpopulations—reduction of Tc cells (CD8+) and increase of activated T cells (CD3+CD25+)—confirmed the beneficial effect of the applied ASIT. In addition, a significantly higher percentage of Treg cells (CD4+CD25+FOXP3+) was noted in cAD patients before treatment compared to healthy dogs. After 3 months of therapy, the percentage of Tregs significantly decreased, and after 6 months, it increased significantly again.
Faith, Fear, and Facts: A COVID-19 Vaccination Hesitancy Intervention for Black Church Congregations
Authors: Peteet Bridgette , Watts Valerie , Tucker Eunique , Brown Paige , Hanna Mariam , Saddlemire Amanda , Rizk Miriam , Belliard Juan Carlos , Abdul-Mutakabbir Jacinda C. , Casey Samuel , Simmons Kelvin
Published: June 2022

Background: Blacks are dying from the novel coronavirus of 2019 (COVID-19) at disproportionate rates and tend to have more COVID-19 vaccine hesitancy than Whites. These disparities may be attributable to health knowledge and government/medical mistrust stemming from negative experiences with the medical system historically and presently (e.g., the Tuskegee Experiment, provider maltreatment). Method: The present study assessed COVID-19 vaccine hesitancy and the effectiveness of a 1.5 h, dialogue-based, web intervention hosted by an academic–community partnership team. The webinar included approximately 220 male and female, English speaking, Black churchgoers in the western U.S. The webinar focused on the psychology of fear and facts about the vaccine development. Results: The sample was mostly females who had higher vaccine hesitancy than men. A third of participants feared hospitalization if they contracted COVID-19. Many participants reported that learning facts about COVID-19 was most impactful. Statistical analyses indicated an increased willingness to get vaccinated after the webinar in comparison to before (t(25) = −3.08, p = 0.005). Conclusion: The findings suggest that virtual webinars may be effective at reducing COVID-19 vaccine hesitancy among Black churchgoers and may be applicable in addressing other health behaviors.
Safety and Efficacy of an Oncolytic Adenovirus as an Immunotherapy for Canine Cancer Patients
Authors: Martín-Carrasco Clara , Delgado-Bonet Pablo , Tomeo-Martín Beatriz Davinia , Pastor Josep , de la Riva Claudia , Palau-Concejo Paula , del Castillo Noemí , García-Castro Javier , Perisé-Barrios Ana Judith
Published: June 2022

The use of oncolytic viruses is an innovative approach to lyse tumor cells and induce antitumor immune responses. Eight dogs diagnosed with carcinoma/adenocarcinoma were intratumorally treated with ICOCAV15, an oncolytic canine adenovirus (CAV). To evaluate the treatment’s safety, a blood count, biochemistry, and coagulation test were performed before treatment and during follow-up. Immune populations were analyzed by flow cytometry. Anti-adenovirus antibodies were also determined. The immune infiltration, vascularization, and viral presence in the tumor were determined by CD3, CD4, CD20, CD31 and CAV by immunohistochemistry. All the dogs maintained a good quality of life during follow-up, and some had increased median survival time when compared with dogs treated with chemotherapy. No treatment-related adverse effects were detected. The Response Evaluation Criteria In Solid Tumors criteria were also assessed: two patients showed a partial response and the rest showed stable disease at various times during the study. ICOCAV15 was detected inside the tumor during follow-up, and antiviral antibodies were detected in all patients. Furthermore, the tumor-infiltrating immune cells increased after viral administration. Therefore, we suggest that intratumorally administered ICOCAV15 could represent as a new tool for the treatment of canine carcinoma because it is safe, well-tolerated by dogs, and shows promising results.
Macroscopic Lattice Boltzmann Method for Shallow Water Equations
Authors: Zhou Jian Guo
Published: June 2022

The lattice Boltzmann method (LBM) is characterised by its simplicity, parallel processing and easy treatment of boundary conditions. It has become an alternative powerful numerical method in computational physics, playing a more and more important role in solving challenging problems in science and engineering. In particular, the lattice Boltzmann method with the single relaxation time (SLBM) is the simplest and most popular form of the LBM that is used in research and applications. However, there are two long-term unresolved problems that prevent the SLBM from being an automatic simulator for any flows: (1) stability problem associated with the single relaxation time and (2) no method of direct implementation of physical variables as boundary conditions. Recently, the author has proposed the macroscopic lattice Boltzmann method (MacLAB) to solve the Navier–Stokes equations for fluid flows, resolving the aforementioned problems; it is unconditionally stable and uses physical variables as boundary conditions at lower computational cost compared to conventional LBMs. The MacLAB relies on one fundamental parameter of lattice size δx, and is a minimal version of the lattice Boltzmann method. In this paper, the idea of the MacLAB is further developed to formulate a macroscopic lattice Boltzmann method for shallow water equations (MacLABSWE). It inherits all the advantages from both the MacLAB and the conventional LBM. The MacLABSWE is developed regardless of the single relaxation time τ. Physical variables such as water depth and velocity can directly be used as boundary conditions, retaining their initial values for Dirichlet’s boundary conditions without updating them at each time step. This makes not only the model to achieve the exact no-slip boundary condition but also the model’s efficiency superior to the most efficient bounce-back scheme for approximate no-slip boundary condition in the LBMs, although the scheme can similarly be implemented in the proposed model when it is necessary. The MacLABSWE is applied to simulate a 1D unsteady tidal flow, a 2D steady wind-driven flow in a dish-shaped lake and a 2D steady complex flow over a bump. The results are compared with available analytical solutions and other numerical studies, demonstrating the potential and accuracy of the model.
A Field Experiment Verification of Theoretical Exponent N1 for FAVAD Method in Defining the Relationship of Pressure and Water Losses
Authors: Dundović Igor , Tadić Lidija
Published: June 2022

The current problem of managing water losses in water supply systems relies on engineering predictions of expected outcomes based on pressure manipulations using hydraulic models or other computational methods. The objective of this experiment was to conduct a field test to validate the theoretical N1 exponent of the fixed and variable area discharges (FAVAD) method. By knowing the pipe material and measuring the pressure and minimum night flow (MNF), the N1 exponent can be defined and compared to recommendations in the literature. Field measurements and experiments were performed in a small settlement in Croatia consisting of 278 house connections and 7.4 km of PVC material pipe network. Pressure manipulation was performed on a pressure-reducing valve (PRV). The resulting value of N1 = 1.76 from the experiment agrees with the literature graphs, which indicate a value of N1 between 1.5 and 2.0. Considering the difference between the studied values and the theoretically calculated MNF of 4%, it can be concluded that the implementation of the presented methodology to determine the N1 exponent can be used in practice. This type of field testing is important because such tests are difficult to perform due to the extensive pressure manipulations during the tests, which can affect the consumers and cause disturbances in the water distribution.
Water-Saving Potential of Different Agricultural Management Practices in an Arid River Basin
Authors: Zhang Wang , Tian Yong , Feng Yu , Liu Jie , Zheng Chunmiao
Published: June 2022

Water scarcity threatens food security in arid areas, highlighting the importance of water-saving agriculture for food production. Agricultural management practices are developed to improve water-use efficiency, and their water-saving effects are generally evaluated at the field scale rather than the regional scale. To figure out the regional water-saving potential of irrigation methods and mulching practices, the FAO AquaCrop model was first calibrated and validated at the three experimental stations. With aggregating spatial information, a distributed model was constructed and validated in a typical arid river basin of northwest China. Twelve combinations of soil mulching (plastic and straw) and irrigation methods (basin, furrow, drip, and subsurface drip) were simulated using the model to evaluate the effect of agricultural management practices on crop evapotranspiration (ET), crop water productivity, and regional water consumption. The results showed that soil mulching, advanced irrigation methods, and their combinations reduced noneffective soil evaporation (E) and the E/ET ratios and improved crop water productivity. Plastic mulching combined with subsurface drip irrigation is the most promising practice, increasing the crop water productivity of seed maize and spring wheat by 18.2% and 11.1% on average and reducing regional crop water consumption by 7.7% (75.0 million m3) and 7.4% (72.7 million m3), respectively. The reduction in irrigation water extraction ranged from 20.6% under furrow irrigation with straw mulching to 68.7% under subsurface drip irrigation with plastic mulching. This study quantitatively assessed the water-saving potential of soil mulching, irrigation methods, and their combinations to reduce agricultural water use, offering practical implications for the management and development of water-saving agriculture in arid areas.
Power Curtailment Analysis of DC Series–Parallel Offshore Wind Farms
Authors: Lakshmanan Padmavathi
Published: June 2022

This paper analyzes one of the most important power capture challenges of the DC series–parallel collection system, called the power curtailment losses. The wind speed difference between the series-connected turbines causes over- and under-voltage conditions in the output voltage of the MVDC (medium-voltage DC) converters of the wind turbine. The power curtailment losses caused by the upper-voltage tolerance levels of the MVDC converters of the wind turbines are analyzed considering a redundancy-based upper-voltage limiting condition. This analysis emphasizes the importance of choosing suitable voltage tolerance levels for the MVDC converters of wind turbines based on the wind farm configuration. The annual energy curtailment losses are quantified and evaluated by a comparative case study performed on a DC series–parallel-connected wind farm rated at 200 MW with the redundancy-based upper-voltage limiting condition.
The Formation of Public Opinion In Foreign Policy: An Investigation of Turkey–Netherlands Diplomatic Tensions Portrayed By Hurriyet, Sabah, And Sozcu Daily National Newspapers
Authors: KARADUMAN Murad , DURU Muhammet Erdem
Published: June 2022

The period in which academic interests intensify on the concept of public opinion on a controversial issue is observed to be in parallel with the period in which migration from villages to cities accelerate and mass societies begin to emerge. During the same period, the concept also gained importance in political life. At the moment, all powers have to take into account the element of public opinion when making decisions both in domestic policy and in foreign policy. Public opinion has an importance on domestic policy as well as on foreign policy in terms of influencing decisions. Mass media play an important role in establishing, informing, and spreading the public opinion.The purpose of this study is to analyze the diplomatic tension between the Netherlands and Turkey, which arose beginning on the first days of March 2017 and became a full-blown crisis on March 10th and 11th, through discourse analysis of newspapers’ headlines on the axis of mass media, public opinion, and foreign policy. For this purpose, the discourse analysis model of Teun A. Van Dijk was used and the front pages of Hürriyet, Sabah, and Sözcü newspapers were analyzed starting from March 12th, 2017 on which the incident appeared on press to April 17th, 2017, on which first unofficial results of Constitutional Amendment Referendum of April 16th were announced to the public. The findings of this study suggest that newspapers display an ideological bias rather than informing the public about foreign policy.
Modern approaches to the diagnosis of occupational hearing loss in workers exposed to noise
Authors:   Federal Budget Institution of Science Ufa Research Institute of Occupational Medicine and Human Ecology, Volgareva Alfiya D. , Shaykhlislamova Elmira R. ,   Scientific, Organizational and Methodological Work, Federal Budget Institution of Science Ufa Research Institute of Occupational Medicine and Human Ecology, Gallyamova Svetlana A. ,   Federal Budget Institution of Science Ufa Research Institute of Occupational Medicine and Human Ecology, Gimranova Galina G. ,   Ufa Research Institute of Occupational Medicine and Human Ecology, Professor of therapy and occupational diseases of Bashkir State Medical University, Valeeva Elvira T. ,   Ufa Research Institute of Occupational Medicine and Human Ecology, Associate Professor of therapy and occupational diseases of Bashkir State Medical University, Chudnovets Guzel M. ,   Ufa Research Institute of Occupational Medicine and Human Ecology, Galimova Rasima R. ,   Ufa Research Institute of Occupational Medicine and Human Ecology
Published: June 2022

Due to the high prevalence of professional hearing loss, the difficulty of making decisions on the further working capacity of the employee, the issues of objectification of the assessment of the hearing condition among employees of «noise» productions, ensuring their reliability are very relevant. Based on the analysis of the results of tonal threshold audiometry and registration of short-latency auditory evoked potentials in 30 patients with impaired auditory function of professional origin, the difference in latencies of registered potentials, amplitudes and intervals was determined in comparison with a group of persons without industrial acoustic contact. The present study has shown that the test has sufficient informativeness in solving complex examination issues of interned patients with comorbid pathology of the circulatory organs by this age, and can be recommended for use for differential diagnosis of lesions of the central parts of the auditory analyzer in case of discrepancy with the results of tonal threshold audiometry.
Augmented video consultations in care homes during the COVID-19 pandemic: a qualitative study
Authors: Ochieng Lorraine , Salehi Mahan , Ochieng Rebecca , Nijhof Dewy , Wong Richard , Gupta Vinay , Prasad Rishabh , Ochieng Bertha
Published: June 2022

Background

The COVID-19 pandemic necessitated an unprecedented implementation of remote consultations in UK primary care services. Specifically, older adults in care homes had a high need for infection prevention owing to their existing health conditions. GP practices in the East Midlands incorporated augmented video consultations (AVC) with the potential to support remote healthcare assessments for older adults at care homes.

Aim

To explore GPs' and care home staff's experiences of the use of AVC as a mechanism to perform remote examinations of older adults in care homes.

Design & setting

Qualitative interviews were conducted with GPs and care home staff in the East Midlands, UK, during May–August 2020.

Method

A convenience sample of GPs (n= 5), nurses (n= 12), and senior healthcare assistants (n= 3) were recruited using a purposive approach. Data were collected through semi-structured telephone interviews and analysed using framework analysis.

Results

Findings from participants indicated that AVC enabled real-time patient examinations to aid diagnosis and promoted person-centred care in meeting the needs of older adults. The participants also discussed the challenges of video consultations for patients with cognitive impairment and those receiving end-of-life care.

Conclusion

AVCs show great potential in terms of GPs providing primary care services for care homes. However, healthcare staff must be involved in the development of the technology, and consideration should be given to the needs of older adults with cognitive impairment and those receiving end-of-life care. It is also vital that training is available to encourage confidence and competency in implementing the technology.
The Effects of Inductive-Deductive Grammar Instruction on Students’ Grammatical Accuracy
Authors: Noveria Anita
Published: June 2022

The research investigated the effect of inductive-deductive teaching instruction developed from the five-step procedure by Widodo (2006). To be more specific, this research attempted to explore the significant difference between the combined inductive-deductive approach and conventional approach (deductive approach only) on the EFL students’ grammar achievement. A quasi-experimental design specifically non-equivalent group design was applied in this research in which the two experimental and control groups were compared. The subject of this research was the first-year university students of UIN Alauddin Makassar who were registered in the intensification program of English language. The instruments used were the initial and final tests of students. The results showed that after treatment, the experimental group increased by 0.36 or 36% and the control group was only 0.22 or 22%. In conclusion, there were significant achievement differences between the two groups after undergoing treatment: the combined inductive-deductive approach (experimental group) and deductive approach (control group).
The Use of VGPM to Estimate Oceanic Primary Production: A “Tango” Difficult to Dance
Authors: Lee Zhongping , Marra John F.
Published: June 2022

One of the primary goals of launching an ocean color satellite is to obtain over the global ocean synoptic measurements of primary production (PP), a measure of phytoplankton photosynthesis. To reach this ultimate goal, in addition to precise measurements of radiance at the satellite altitude and robust data processing systems, a key requirement is to link primary production with satellite-derived products, where a model must be developed and applied. Although many models have been developed in the past decades, the vertically generalized production model (VGPM) developed by Behrenfeld and Falkowski, due to its simplicity and ease of use with satellite products, has been a de facto “standard” for the estimation of PP from ocean color measurements over the past 20+ years. Thus, it has significantly influenced the ocean color remote sensing and the biological oceanographic communities. In this article, we discuss the limitations of VGPM (and PP models based on chlorophyll concentration) in estimating primary production.
Danish Water Supply Areas and their links to water production facilities: an open-access data set
Authors: Schullehner Jörg
Published: June 2022

This data set establishes the missing link between drinking-water quality monitoring data at the water production facility level in the Danish national geodatabase Jupiter and supply areas. Water Supply Areas (WSAs) were collected at municipality level, digitised and linked to the waterworks they are supplied by. Infrastructural changes between 1978 and 2019 were taken into account by allowing WSA polygons to change over time. The number of active WSAs decreased from 3172 in 1978 to 2602 in 2019. The data set consists of longitudinal WSA polygons and a table linking WSAs to the water production facility identification in the Jupiter database, allowing the estimation of current and historical drinking-water quality across Denmark. In combination with the Danish Address Register and the Civil Registration System, this data set allows exposure assessments of drinking-water quality at high spatiotemporal resolution for the entire Danish population. Therefore, this data set is an essential part of studying health effects of drinking-water quality in epidemiological research in Denmark.
The Bow and Arrow in Sangam Literature
Authors: P.L Malathi , G Stephen
Published: June 2022

Scholars point out that the Sangam period dates back to the Veerayuga period. It is also believed to be the Iron Age. Society in the longest hierarchy of mankind. It can be seen from the association's work that the various types have evolved and evolved into different stages. The association work is not complete and does not belong to the same period, and there is ample evidence to learn about the different ethnic community in the association. Exoduses speak of emotional departmental discipline and Exodus speaks of heroic battles. Songs praising the war also showcase the weapons. Data on tools such as bows and arrows are also available. The bow and arrow are symbolically identified with certain concepts with a social background. The bow and arrow set out to illustrate societal evolution and biological values. The purpose of this article is to discuss the movements of the bow and arrow community, although numerous weapons are found in literary references.
Meningkatkan Kemampuan Pemecahan Masalah Matematika Siswa Melalui Media Pembelajaran Interaktif Articulate Storyline Pada Materi Peluang
Authors: Habuke Fregita , Hulukati Evi , Pauweni Khardiyawan A.Y
Published: June 2022

This study aims to improve students' mathematical problem-solving ability using articulate storyline interactive learning media in SMP N 2 Telaga Biru. This research is a Classroom Action Research. The subjects are grade VIII students consisting of 20 students. The data collection techniques include observation and test. The data analysis includes data analysis of teacher observations, student observations, and analysis of problem-solving ability test results. The research procedure includes action planning, implementation, observation, and reflection. This research was conducted in stages with two cycles, namely cycle I and cycle II. The tests and observations obtained from the two cycles showed that students' mathematical problem-solving ability increased in cycle II.
Pemodelan Survival Pasien Covid-19 dengan Hazard Non-Proporsional
Authors: Hidayat Rahmat , Sam Marwan , Wardi Ridha Yulyani , Iskandar M. Ishaq
Published: June 2022

This article compares two survival models namely Extended Cox and Stratified Cox. These two survival models are alternative models if the proportional assumption of the Cox proportional hazard model is not met. The comparison of the models was carried out using data on the resilience of Covid-19 patients in Palopo City, South Sulawesi. After modeling using the Extended Cox and Stratified Cox models, the AIC values are compared to see a better model. The results obtained indicate that modeling the resilience of Covid-19 patients in Palopo City is better by using Stratified Cox.
Jel İçeren Sıvılaşabilir Zeminde Donma Direncinin İncelenmesi
Authors: GÜLTEKİN Asker Alp , EVİRGEN Burak
Published: June 2022

Dinamik etkilere maruz kalan ince kumlu-siltli zeminlerde, düşük plastisiteli killerde ve hatta gelen ivmenin büyüklüğüne bağlı olarak çakıllı zeminlerde dahi sıvılaşma olayı meydana gelebilmektedir. Bu sorunu önlemek amacıyla mekanik veya kimyasal zemin iyileştirme teknikleri kullanılmaktadır. Yüksek su emme kapasitesine sahip sodyum poliakrilatın zemine karıştırılması veya enjeksiyonu da kimyasal zemin iyileştirme tekniklerindendir. Ortamdaki su ile etkileşime girdiğinde jel forma dönüşen bu malzemenin, dona maruz kalan bölgelerde zemin içerisinde donması durumundaki davranışı bilinmemektedir. Bu amaçla, referans numuneleriyle birlikte %5,00, %10,00, %15,00 ve %20,00 oranlarında sodyum poliakrilat jeli içeren kumlu zemin numuneleri −20℃’de dondurulmuş ve serbest basınç deneyi uygulanmıştır. Ayrıca, kumlu numunelere ağırlıkça %5,00 oranında bentonit kili eklenerek deneyler tekrarlanmıştır. Jel içeriğiyle birlikte su muhtevasının artmasına bağlı olarak tüm numunelerin serbest basınç dayanımları artmasına rağmen, bentonit içeren numunelerde ortalama %14,00 daha düşük değerler elde edilmiştir. Diğer taraftan bentonit içermeyen donmuş numunelerde genel olarak birim şekil değiştirme değerleri artarken, bentonitli numunelerde azalmaktadır. Zemin içerisinde jel formda olan viskoz yapı, donma işlemi sırasında meydana gelen hacim artışını sönümleyerek donma kabarması sorununu engellemektedir. Ancak, sodyum poliakrilat ile iyileştirilen sıvılaşmaya karşı hassas kumlu zeminlerde yetersiz doygunluk durumunda taşıma kapasitesi kayıplarının dikkate alınması gerekmektedir.
Kil-Biyokütle Kompoziti: Ni (II)’nin Etkin Giderimi için Çevre Dostu Hibrit Adsorban
Authors: SAYIN Fatih
Published: June 2022

Bu çalışmada, doğal kil minerali: Capsicumannuum (C. annuum) L. çekirdekleri bazlı kompozit bir adsorban (CCAC) hazırlanmıştır. CCAC'nin adsorpsiyon performansı, Ni (II) uzaklaştırma ve adsorpsiyon kapasitesi açısından değerlendirildi. Deneysel koşullar, metal çözeltisinin başlangıç pH'ı, CCAC miktarı, başlangıç metal iyonu konsantrasyonu ve temas süresi parametreleri araştırılarak optimize edilmiştir. CCAC ile Ni (II) adsorpsiyonu için optimum pH: 7.0, CCAC miktarı: 0.06 g ve temas süresi: 20 dakika olarak bulunmuştur. Adsorpsiyon izotermleri sık kullanılan modeller ile belirlenmiştir. Langmuir izoterm modeli ile maksimum tek tabakalı adsorpsiyon kapasitesi 126mg g-1 olarak belirlenmiştir. CCAC’nin fonksiyonel grupları ve yüzey morfolojisi sırasıyla FT-IR ve SEM analizleri kullanılarak araştırılmıştır. Bulgular, kimyasal ve kendiliğinden gerçekleşen bir Ni(II) adsorpsiyon sürecini işaret etmiştir. Son olarak, bu çalışmadan elde edilen tüm sonuçlar, basit olarak üretilebilen, maliyeti uygun ve sağlam bir kompozit adsorban olan CCAC'nin nikel iyonları ile kirlenmiş suların arıtılması için uygun bir aday olduğunu göstermektedir.
The Antiviral Effect of the Propolis from Turkey on the Replication of Autographa californica nuclear polyhedrosis virus (AcNPV) Developed in Spodoptera frugiperda Cell Culture
Authors: ERTÜRK Ömer , BAŞKAN Ceren
Published: June 2022

In this study, the influence of propolis extracts gathered from Turkey on the replication of Autographa californica nuclear polyhedrosis virus (AcNPV) developed in Spodoptera frugiperda culture was researched through examining changes in cytopathic influences, hydroxyl radical mediated DNA damage and progeny virus concentration. By making use of propolis extract, we found inhibiting effect on cytopathic changes and DNA damage. It was found that propolis extracts on the cytopathic changes and hydroxyl radical-mediated DNA damage were similar to the control. The results showed that propolis has a protective effect on DNA exposed with H2O2. In terms of the production of occlusion bodies in Sf9 cells, no important difference was found between the average percentage of contaminated cells in contaminated control cells when the concentration of propolis is 3.125, and 1.5625 μg/mL (4.018 (Plaque forming units (PFU) pfu/mL and 5.145 pfu/mL respectively) (p<0.05) and no significant difference was found between the average number of occlusion bodies in the contaminated control cells and the contaminated cells in the concentration of propolis. Respectively 98.70% and 98.67% reduction were found in virus titter with propolis extracts when the concentration of propolis extracts 100, 50 μg/mL were included 1 h p.i. (p<0.05). However, different concentrations of propolis extract reduced the number of progeny viruses significantly.
Ergenlik Döneminde Zihinsel Engelli Çocuğu Olan Annelerin Deneyimlerinin İncelenmesi
Authors: HAZAR Zehra , BÜTÜN AYHAN Aynur
Published: June 2022

Bu çalışmada ergenlik döneminde zihinsel engelli çocuğa sahip annelerin deneyimlerinin incelenmesi amaçlanmıştır. Ergenlik döneminde zihinsel engelli 15 çocuk annesi çalışmaya dahil edilmiştir. Çocuk ve aile hakkında bilgi almak için “Genel Bilgi Formu” ayrıca annelerin yaşam deneyimleri hakkındaki görüşlerini belirlemek amacıyla “Yarı-Yapılandırılmış Görüşme Formu” kullanılmıştır. Araştırma kapsamında elde edilen veriler MAXQDA 2020 programı kullanılarak analiz edilmiştir.Çalışmamızda, annelerin engelli çocuklarının dünyaya gelmesinden ergenlik sürecine kadarki deneyimleri sırasında yaşadıkları en büyük problemin psikolojik rahatsızlıklar olduğu tespit edilmiştir. Annelerin deneyimlediği bu süreç içerisinde mevcut ve geleceğe dair problemler; bilgilendirme eksikliği, bağımsızlık ve gelecekte çocuklarına kimin bakacağı yönünde endişelerinin olduğu vurgulanmıştır. Bazı anneler tarafından, ergenlik döneminin getirdiği değişikliklerin çocuklarının davranışlarında genellikle farklılık yaratmadığı ifade edilirken, bazı anneler bu değişim sürecine uyum sağlamakta zorlandıklarını belirtmişlerdir. Bununla birlikte devlet desteği, eğitim imkânlarının yetersizliği, nitelikli eğitimci sayısının azlığı da yaşanan problemler olarak ifade edilmiştir. Çalışmada, ergenlik dönemindeki zihinsel engelli çocuk ile ilgili bilgilendirme çalışmalarının yapılması ve annelerin sorunlarının giderilmesine yönelik psikolojik destek programlarının oluşturulması önerilmektedir.
Kajian Pustaka Sintesis Nanoselulosa dari Tandan Kosong Kelapa Sawit sebagai Filler Pembuatan Tisu Toilet
Authors: Hidayatulloh Irwan , Widyanti Emmanuela Maria , Aztaris Chandra , Melanitria Awalum , Lidya Elizabeth
Published: June 2022

Tisu merupakan salah satu jenis kertas yang terbuat dari serat kayu. Peningkatan kebutuhan tisu di masyarakat meningkatkan penebangan pohon. Tandan kosong kelapa sawit (TKKS) merupakan limbah dari kelapa sawit yang mengandung selulosa tinggi dan memiliki potensi untuk dimanfaatkan sebagai filler dalam pembuatan tisu. Penelaahan kajian pustaka ini dilakukan untuk mengetahui potensi pemanfaatan nanoselulosa TKKS sebagai filler pembuatan tisu toilet. Sesuai persyaratan, bahan untuk tisu diharapkan mempunyai kandungan selulosa 70 %. Perhitungan kadar selulosa optimum dengan delignifikasi ditentukan dari regresi linear menggunakan software SPSS Statistics 25. Rancangan variabel proses menggunakan software Minitab 19. Metode perancangan yang digunakan dalam percobaan adalah placket burman. Hasil delignifikasi optimum didapatkan pada suhu 150-160°C, NaOH 15-17,5%, dan waktu 20-40 menit. Ukuran diameter nanoselulosa terkecil sebesar 5-10 nm, didapatkan dengan proses hidrolisis asam menggunakan H2SO4 30% pada suhu 60°C selama 120 menit. Nanoselulosa dapat digunakan sebagai filler dalam pembuatan tisu toilet, karena dapat menghasilkan rongga yang dapat menyerap molekul air dan meningkatkan kekuatan lapisan kertas.

Tissue is a type of paper, made from wood fibers. The elevation of tissue necessity in the society will rise the trees logging. Oil palm empty fruit bunches (OPEFB) is waste from oil palm mill which contains high cellulose and has a lot of potential to be used, one of that is as a filler in the manufacture of tissue. The literature review was conducted to determine the potential utilization of cellulose in OPEFB as a filler in the manufacture of toilet paper. According to the requirements, the material for tissue is expected to have a cellulose content of 70%. Estimation of optimum cellulose content with delignification was determined by linear regression using SPSS Statistics 25 software. The optimum delignification results were obtained at a temperature of 150-1600C, NaOH 15-17.5%, and 20-40 minutes. The lowest diameter of nanocellulose is 5-10 nm, obtained by acid hydrolysis using 30% H2SO4 at 600C for 120 minutes. The nanocellulose is used as a filler in the manufacture of toilet paper, because it can produce holes that can absorb water molecules and increase the strength of the paper layer.
KATILIM VE MEVDUAT BANKALARININ FARKINDALIK DÜZEYİNİN KARŞILAŞTIRILMASI: İÇ ANADOLU BÖLGESİNDE BİR ARAŞTIRMA
Authors: KILINÇ Ebrar , AYDIN Yüksel
Published: June 2022

Bu çalışmada, İç Anadolu Bölgesinde faaliyet göstermekte olan katılım bankaları ve mevduat bankalarının, banka müşterileri tarafından neden tercih edildiğinin ve banka müşterilerinin katılım ve mevduat bankaları üzerindeki memnuniyet derecesi ölçülmesi amaçlanmıştır. Bu amaçla çalışmada kullanılan veri setine ilişkin değerlendirmelerin yapılabilmesi için frekans analizleri ve parametrik istatistiksel testlerden yararlanılmıştır. Çalışmanın ampirik sonuçlarından elde edilen bulgulara göre ise, katılım bankalarının banka müşterileri tarafından tercih edilmesinin en önemli sebebi, literatürde iddia edildiği gibi faiz hassasiyeti olmayıp, günümüzde katılım bankalarının mevduat bankaları ile eşit haklara sahip olmasından kaynaklandığı tespit edilmiştir. Ayrıca çalışmada, internet bankacılığı ve mobil bankacılık işlemlerinin, katılım ve mevduat bankalarının tercih edilmesindeki en önemli iki etken olduğu ve bireylerin mevduat bankalarını katılım bankalarına kıyasla daha fazla tercih ettiği sonucuna da ulaşılmıştır.
Interacciones en grupos de aprendizaje on line
Authors: Tirado Morueta Ramón , Aguaded Gómez José Ignacio , Méndez Garrido Juan Manuel
Published: June 2022

Este estudio, en el marco del proyecto "Drog@", del Programa de la Unión Europea "Interreg III-A" (España-Portugal), se propone describir el progreso de las interacciones en grupos de aprendizaje en red como un indicador de la consolidación del grupo, diferenciando entre intervenciones centradas en la tarea, en los contenidos y de carácter afectivas. Tras explorar la evolución de tales tipos de interacciones a lo largo de un curso, identificamos cuatro tipos de modelos: crecimiento final, discreto, regular y decreciente. Se observan indicios de la importancia de las intervenciones afectivas en su papel de estímulo a la participación, la presencia social, y el sentimiento de pertenencia y cooperación entre sus miembros. No obstante, hay que avanzar en estudios que combinen estrategias cuantitativas, ampliando el control a variables personales y ambientales que permitan obtener resultados más concluyentes y predictivos sobre el comportamiento y evolución de los grupos de aprendizaje on line.
Metodologías activas en la dirección estratégica de la empresa: implicación de los alumnos en el análisis estratégico de la universidad
Authors: Gargallo Castel Ana
Published: June 2022

En el marco del Espacio Europeo de Educación Superior, se desean adaptar las actividades y prácticas desarrolladas en el campo de la docencia con los alumnos, dentro y fuera del aula, con el objetivo de que los estudiantes alcancen nuevas competencias y habilidades que les sean útiles en su posterior desempeño profesional. Entre las prácticas con las que se ha buscado lograr implicación y compromiso de los alumnos, dentro de la asignatura Dirección Estratégica de la Empresa, se encuentra el estudio aplicado del análisis estratégico a empresas con las que tengan una relación directa, entre ellas la universidad. Tras este análisis estratégico los alumnos han concluido que la universidad española se enfrenta, actualmente, a importantes cambios en el entorno a los que debe responder con una adecuada planificación estratégica, que englobe todos sus ámbitos de actuación y que apoye el fortalecimiento de una estrategia de diferenciación basada en la calidad y la excelencia. A modo de ejemplo, se ofrecen los resultados más destacables del análisis DAFO realizado por los alumnos de la asignatura para la Facultad de Ciencias Sociales y Humanas, centro al que pertenecen.
O ensino de Ciências e Biologia nas turmas de eja: experiências no município de Sorriso-MT
Authors: Morais Francisco Alexandro de
Published: June 2022

A Educação de Jovens e Adultos na atualidade é uma alternativa viável para que as pessoas possam retomar seus estudos e garantir uma formação profissional e intelectual. Contudo, suas propostas curriculares são bastante compactas, podendo vir a dificultar a aprendizagem dos alunos devido à sobrecarga de conteúdo em um curto espaço de tempo, principalmente das disciplinas da área das Ciências Biológicas. Por esta razão, o trabalho analisou a proposta curricular das disciplinas de Ciências e Biologia nas turmas da EJA do Distrito de Boa Esperança do Norte no município de Sorriso - MT, além de verificar a compreensão e aprendizagem dos conteúdos por parte dos alunos com a utilização de recursos diversos. A pesquisa foi realizada com os alunos da EJA do Ensino Fundamental e Médio da Escola Estadual Cristiano de Araújo Pires entre outubro e novembro do ano de 2007. Foram utilizadas aulas expositivas, leituras e produção de textos baseados em livros didáticos, revistas e artigos científicos nas disciplinas de Biologia e Ciências, além da análise das propostas curriculares dessas disciplinas. Observou-se que os alunos conseguiram contextualizar muitos dos conteúdos e temas das disciplinas de Ciências e Biologia, principalmente com a utilização do livro didático, associado com revistas e artigos científicos. As propostas curriculares destas disciplinas ainda apresentam sobrecarga de conteúdos em relação à sua carga horária, havendo dessa forma necessidade de uma reformulação para disponibilizar apenas conteúdos de relevância para a realidade dos alunos.
A criança e o jogo: um olhar sobre formas de negociação
Authors: Saad Guirra Frederico Jorge , Prodócimo Elaine
Published: June 2022

O jogo e as brincadeiras são formas de atividade bastante interessantes e constituem um importante instrumento de troca entre a criança e o meio cultural em que ela vive. No entanto, para que essa troca aconteça, tornam-se necessários certos tipos de negociações sobre as regras que irão permear as brincadeiras, para que elas ocorram de maneira educativa e de forma a garantirem a satisfação de quem participa delas. Como processos educativos, deveriam ocupar, na escola, um importante papel e tornarem-se um grande aliado dos professores, principalmente na Educação Infantil, como possibilidade de mediar o conhecimento. Com o intuito de investigar a natureza das negociações ocorridas no contexto do jogo e como elas surgem, foi realizada uma pesquisa entre crianças do Centro Social Urbano, da Rede Municipal de Barra do Garças/MT, cujos resultados são relatados neste texto, que conclui com a afirmação de que, no jogo e na brincadeira, a criança se identifica com o meio, manifesta suas emoções, tendo oportunidade de verdadeira aprendizagem.
Enseñanza plurilingüe en centros de educación secundaria: análisis de resultados
Authors: Grisaleña Urrecho Jesús , Alonso García Esmeralda , Campo Postigo Alejandro
Published: June 2022

Las distintas investigaciones sobre el uso del inglés como lengua vehicular en los modelos de enseñanza plurilingüe, afirman que se aumenta el ritmo de adquisición de la lengua sin que se produzcan efectos negativos apreciables. La presente investigación surge del interés por analizar el grado de eficacia de los proyectos de los centros que participan en la Experiencia Plurilingüe en la Comunidad Autónoma del País Vasco. Combina los aspectos cualitativos del análisis de casos con otros de tipo más cuantitativo en los que se analizan los resultados obtenidos por el alumnado en diferentes pruebas de competencia lingüística en inglés.Las pruebas se han realizado a lo largo de dos curso escolares intentado comprobar el progreso conseguido por el alumnado que ha participado en la experiencia. De igual manera, se han recabado datos y opiniones de los diferentes colectivos implicados: alumnado, profesorado y familias. Tanto unos como otros son la base de las conclusiones y recomendaciones que se presentan en la investigación.
Contribuições da metodologia da modelagem matemática para os cursos de formação de professores
Authors: Cargnin-Stieler Marinez , Bisognin Vanilde
Published: June 2022

Neste artigo descrevem-se os resultados de uma pesquisa realizada com alunos do curso de Licenciatura em Matemática, utilizando-se a M odelagem Matemática como metodologia de ensino. Por meio de uma experiência concreta, investigaram-se as contribuições e possibilidades que essa metodologia pode oferecer à aprendizagem de conceitos matemáticos. Verificou-se que a M odelagem Matemática possibilitou o contato com problemas do cotidiano e de interesse dos alunos, o desenvolvimento da capacidade de criar situações-problema, de fazer conjecturas, de resolver, de analisar e de interpretar as soluções, relacionando-as com o tema proposto. Por parte dos alunos, percebeu-se também uma mudança de atitude. Houve comprometimento com o trabalho desenvolvido; interesse e motivação pela disciplina; desenvolvimento de habilidades para a investigação e compreensão do papel sociocultural da matemática.
Possibilidades educativas e de inclusão social e digital com a TVDi: uma breve análise do cenário brasileiro
Authors: Vizconde Veraszto Estéfano , Oliveira Simon Fernanda de , Silva Dirceu da , Ferreira do Amaral Sérgio , Pires de Camargo Éder , Assis de Miranda Nonato
Published: June 2022

Este trabalho procura apresentar dados que justifiquem a utilização da Televisão Digital interativa (TVDi) como meio capaz de auxiliar na inclusão digital e social no Brasil. Através de dados do IBGE (Brasil, 2008a, 2008b) é possível perceber que a TV é o segundo utensílio mais presente nos domicílios brasileiros. Somando a esse fato o precário acesso à internet, vigente em nosso país, é fácil demonstrar que a migração das mais variadas mídias para o ambiente televisivo digital e interativo poderá não só mudar hábitos e consumo da nossa população, como também ser fator decisivo para uma Educação a Distância (EAD) diferenciada e consistente.