bluuebunny/crossref_metadata_2025 huggingface dataset:
Table S13 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Table S13. Random forest predictive performance results for only primary tumor samples. Full results for all random forest models using 15 different feature sets, trained on only primary tumor samples (n = 69). Mean and standard deviation AUC results across 500 evaluations are reported for both OS and PFS.
Supplementary Fig S14 from CD36+ Proinflammatory Macrophages Interact with ZCCHC12+ Tumor Cells in Papillary Thyroid Cancer Promoting Tumor Progression and Recurrence
Authors: Zhang Xin , Guo Limei , Tian Wenyu , Yang Ying , Yin Yue , Qiu Yaruo , Wang Weixuan , Li Yang , Zhang Guangze , Zhao Xuyang , Wang Guangxi , Lin Zhiqiang , Yang Meng , Zhao Wei , Lu Dan
Published: November 2024

Supplementary Figure S14
Table S11 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Table S11. Univariate Cox regression results for only primary tumor samples. Univariate Cox regression results for OS and PFS for all features, restricted to only primary tumor samples.
Supplementary Fig S11 from CD36+ Proinflammatory Macrophages Interact with ZCCHC12+ Tumor Cells in Papillary Thyroid Cancer Promoting Tumor Progression and Recurrence
Authors: Zhang Xin , Guo Limei , Tian Wenyu , Yang Ying , Yin Yue , Qiu Yaruo , Wang Weixuan , Li Yang , Zhang Guangze , Zhao Xuyang , Wang Guangxi , Lin Zhiqiang , Yang Meng , Zhao Wei , Lu Dan
Published: November 2024

Supplementary Figure S11
Supplementary Fig S10 from CD36+ Proinflammatory Macrophages Interact with ZCCHC12+ Tumor Cells in Papillary Thyroid Cancer Promoting Tumor Progression and Recurrence
Authors: Zhang Xin , Guo Limei , Tian Wenyu , Yang Ying , Yin Yue , Qiu Yaruo , Wang Weixuan , Li Yang , Zhang Guangze , Zhao Xuyang , Wang Guangxi , Lin Zhiqiang , Yang Meng , Zhao Wei , Lu Dan
Published: November 2024

Supplementary Figure S10
Supplementary Fig S1 from CD36+ Proinflammatory Macrophages Interact with ZCCHC12+ Tumor Cells in Papillary Thyroid Cancer Promoting Tumor Progression and Recurrence
Authors: Zhang Xin , Guo Limei , Tian Wenyu , Yang Ying , Yin Yue , Qiu Yaruo , Wang Weixuan , Li Yang , Zhang Guangze , Zhao Xuyang , Wang Guangxi , Lin Zhiqiang , Yang Meng , Zhao Wei , Lu Dan
Published: November 2024

Supplementary Fig. S1 Enrichment of CD36+ pro-inflammatory macrophage in cancer correlates with poor outcome of patients with PTC.
Figure S4 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S4. Random forest predictive performance results with increased spatial network trimming threshold. Main text Figure 6 repeated if edges in spatial networks are trimmed with a higher threshold of 100 pixels (∼48.8 μm).
Figure S3 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S3. Univariate Cox regression results with increased spatial network trimming threshold. Covariates found to be significant in Univariate Cox regressions for (A) OS and (B) PFS outcomes. Results are shown for main text Figure 5 if edges in spatial networks are trimmed with a higher threshold of 100 pixels (∼48.8 μm). Hazard ratio estimates are colored by feature category.
Table S1 from An Engineered Self-biomineralized Oncolytic Adenovirus Induces Effective Antitumor Immunity and Synergizes With Immune Checkpoint Blockade
Authors: Wang Shibing , Yang Xue , Ma Ying-Yu , Wu Junjie , Jin Ketao , Zhao Ruibo , Zou Hai , Mou Xiaozhou
Published: November 2024

Table S1. Primer sequences used for qRT-PCR analysis and probe
Figure S2 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S2. Clinical/immunohistochemical feature distributions. Histograms of clinical/immunohistochemical features: (A) age, in years, (B) ATF6 status (histology score), (C) H3K14Ace status (histology score), (D) DUSP1 status (histology score), (E) CBX2 status (histology score), and (F) counts of BRCA Mutation status, where an N/A value indicates that the patient was not tested.
Figure S7 from An Engineered Self-biomineralized Oncolytic Adenovirus Induces Effective Antitumor Immunity and Synergizes With Immune Checkpoint Blockade
Authors: Wang Shibing , Yang Xue , Ma Ying-Yu , Wu Junjie , Jin Ketao , Zhao Ruibo , Zou Hai , Mou Xiaozhou
Published: November 2024

Figure S7. Immuno-gating strategies of flow cytometry analysis.
Figure S5 from An Engineered Self-biomineralized Oncolytic Adenovirus Induces Effective Antitumor Immunity and Synergizes With Immune Checkpoint Blockade
Authors: Wang Shibing , Yang Xue , Ma Ying-Yu , Wu Junjie , Jin Ketao , Zhao Ruibo , Zou Hai , Mou Xiaozhou
Published: November 2024

Figure S5. Individual tumor growth curve. The tumor volume was measured every two or three days. Once the tumor volume of the mouse exceeded 2000 mm3, it was no longer measured.
Figure S14 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S14. Median neighbor distances in the spatial networks. Heatmap of the median distances (μm) between spatial network neighbors of pairs of cell types aggregated across all edges included in the final set of samples.
Figure S10 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S10. Example antibody staining images. Raw antibody staining images are shown here for an example FOV (FOV ID 9).
Supplementary Figure 8 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 8. Correlation between TMB (FoundationOne) and Ecotyper CD8 S3 signature in urothelial carcinoma of the IMVigor210 patient cohort.
Supplementary Figure 5 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 5. The distribution of Ecotyper CD8 T cell S3, epithelial cell S4, and dendritic cell S3 scores in different Lund2 and TCGA molecular subtypes of urothelial carcinomas of the IMVigor210 dataset. TAA burdens are shown as color gradient. P-values are based on two-tailed Welch’s T test. *, P < 0.05, **, P < 0.01, ***, P < 0.001, ****, P < 0.0001.
Supplementary Figure 4 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 4. HEPA based TAB better-prioritized responders in the IC0 group of the IMVigor210 urothelial carcinoma cohort than known CTA burden (left) and FMOne tumor mutation burden (right).
Figure S5 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Authors: Georgiev Peter , Han SeongJun , Huang Amy Y. , Nguyen Thao H. , Drijvers Jefte M. , Creasey Hannah , Pereira Joseph A. , Yao Cong-Hui , Park Joon Seok , Conway Thomas S. , Fung Megan E. , Liang Dan , Peluso Michael , Joshi Shakchhi , Rowe Jared H. , Miller Brian C. , Freeman Gordon J. , Sharpe Arlene H. , Haigis Marcia C. , Ringel Alison E.
Published: November 2024

Supplemental Figure 5
Supplementary Figure 3 from Tumor-Associated Antigen Burden Correlates with Immune Checkpoint Blockade Benefit in Tumors with Low Levels of T-cell Exhaustion
Authors: Wang Yue , Hu Mengying , Finn Olivera J. , Wang Xiao-Song
Published: November 2024

Supplementary Figure 3. The p-values for TAB, CTB, TMB, molecular subtypes, and clinical variables in the multivariate models containing all variables when the effects from other variables are removed. (a) Patient subjects of the IC0 group in the IMVigor210 cohort. (b) Patient subjects of the IC1-2+ group in the IMVigor210 cohort. The p-value of the coefficient of each variable is calculated by ANOVA. The left panel shows multivariate logistic regression to model binary response, adjusting for the presence of other covariates. The right panel shows multivariate Cox proportional hazard regression to model overall survival. Patient subjects stratified by IC0 or IC1-2+ groups in the IMVigor210 cohort are included in the analyses. A type-II ANOVA is applied to the fitted logistic regression or Cox proportional hazard regression models to evaluate the significance of each covariate independently, ensuring that the unique contribution of each marker is assessed in the presence of others. The analysis highlights the relative importance of each marker, with p-values indicating their individual contributions to predicting binary response, after accounting for confounding effects from the other variables.
Figure S7 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S7. Photographs of ALG hydrogels cultured with PBS and H2O2 as indicated.
Figure S16 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S16. Individual tumor growth curves of primary untreated (A) and distant untreated (B) TNBC PDX tumor-bearing mice subjected to different treatments (related to Fig. 7B and C, respectively).
Figure S12 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S12. Individual tumor growth curves of parental MDA-MB-231 tumor-bearing mice subjected to different treatments (related to Figure 5B).
Figure S11 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S11. Semiquantitative statistical analysis of percentages of specific areas affected by pimonidazole based on the fluorescence images in Figure 4I. (***p < 0.001, **p < 0.01).
Figure S1 from Engineered CAR-NK Cells with Tolerance to H2O2 and Hypoxia Can Suppress Postoperative Relapse of Triple-Negative Breast Cancers
Authors: Liu Yan , Chen Jiahui , Tian Jia , Hao Yu , Ma Xinxing , Zhou Yehui , Feng Liangzhu
Published: November 2024

Figure S1. H2O2 contents in the blood and tumor interstitial fluid of parental MDA-MB-231 tumors (A), brain metastatic MDA-MB-231 tumors (B), and MDA-MB-468 tumors (C). (***p < 0.001).
Figure S5 from The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Authors: Pant Ayush , Jain Aanchal , Chen Yiyun , Patel Kisha , Saleh Laura , Tzeng Stephany , Nitta Ryan T. , Zhao Liang , Wu Caren Yu-Ju , Bederson Maria , Wang William Lee , Bergsneider Brandon Hwa-Lin , Choi John , Medikonda Ravi , Verma Rohit , Cho Kwang Bog , Kim Lily H. , Kim Jennifer E. , Yazigi Eli , Lee Si Yeon , Rajendran Sakthi , Rajappa Prajwal , Mackall Crystal L. , Li Gordon , Tyler Betty , Brem Henry , Pardoll Drew M. , Lim Michael , Jackson Christopher M.
Published: November 2024

Figure S5: Ccr6 ablation reduces Treg immunosuppression of CD8 T cells in the context of tumor growth.
Data from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
Authors: Georgiev Peter , Han SeongJun , Huang Amy Y. , Nguyen Thao H. , Drijvers Jefte M. , Creasey Hannah , Pereira Joseph A. , Yao Cong-Hui , Park Joon Seok , Conway Thomas S. , Fung Megan E. , Liang Dan , Peluso Michael , Joshi Shakchhi , Rowe Jared H. , Miller Brian C. , Freeman Gordon J. , Sharpe Arlene H. , Haigis Marcia C. , Ringel Alison E.
Published: November 2024

Abstract
Progressive decline of the adaptive immune system with increasing age coincides with a sharp increase in cancer incidence. In this study, we set out to understand whether deficits in antitumor immunity with advanced age promote tumor progression and/or drive resistance to immunotherapy. We found that multiple syngeneic cancers grew more rapidly in aged versus young adult mice, driven by dysfunctional CD8+ T-cell responses. By systematically mapping immune cell profiles within tumors, we identified loss of tumor antigen–specific CD8+ T cells as a primary feature accelerating the growth of tumors in aged mice and driving resistance to immunotherapy. When antigen-specific T cells from young adult mice were administered to aged mice, tumor outgrowth was delayed and the aged animals became sensitive to PD-1 blockade. These studies reveal how age-associated CD8+ T-cell dysfunction may license tumorigenesis in elderly patients and have important implications for the use of aged mice as preclinical models of aging and cancer.
Patients with Opioid Use Disorder Choosing Treatment with Extended-Release Naltrexone: A 6-Month Naturalistic Study
Authors: Brenna Ida Halvorsen , Waleur Karin Merethe , Benth Jūratė Šaltytė , Solli Kristin K. , Mordal Jon , Løberg Else-Marie , Weimand Bente , Tanum Lars
Published: November 2024

Introduction: The treatment efficacy of extended-release naltrexone (XR-NTX) for opioid use disorder (OUD) has been demonstrated in several studies, but not in naturalistic settings where opioid agonist treatment (OAT) is freely accessible. This study aimed to examine the different treatment outcomes of XR-NTX in a setting where the participants freely chose XR-NTX as a treatment option instead of OAT. Methods: This was a 24-week open-label clinical prospective cohort study conducted in an outpatient setting at five hospitals in Norway. The study included 161 participants aged 18–65 years with OUD. Intramuscular injections of XR-NTX were administered every 4 weeks for 24 weeks. Measurements included retention in treatment, reasons for treatment discontinuation, days of use of opioids, other illicit substances and alcohol, level of heroin craving, treatment satisfaction, and adverse events (AEs). Results: Of 161 included participants, the mean age was 38 years, and 24% were women; 138 received at least one dose of the study medication (modified intention-to-treat [MITT] population), and mean time in treatment was 18.1 weeks (95% CI: 16.8–19.4). The majority of the MITT population (84; 60.9%) completed 24 weeks of treatment in the study. There was a significant decrease in the overall use of opioids (p < 0.001) and the use of alcohol, and other illicit substances were low. The participants generally reported high treatment satisfaction and low heroin cravings. Those who completed the 24 weeks of treatment reported significantly fewer days of opioid use (p < 0.001) and higher treatment satisfaction (p < 0.001) than those who discontinued treatment before 24 weeks. No serious AEs were directly related to XR-NTX use. Conclusion: This study demonstrated high retention rates, decreased opioid use, and low use of other illicit substances and alcohol. Participants also reported low cravings for heroin and high treatment satisfaction. Completion of the full 24-week treatment resulted in lower opioid use and increased treatment satisfaction compared to those who discontinued treatment before 24 weeks. The observed higher retention and reduced opioid use, compared to other studies, may be attributed to participants’ strong motivation for opioid abstinence facilitated by XR-NTX treatment.
“Todos os desaparecimentos são forçados”: entrevista com May-ek Querales e Blanca Martínez
Authors: Araújo Fábio , Azevedo Desirée de Lemos , Rodrigues Lorrane Campos
Published: November 2024

Entrevista realizada por Fábio Araújo (Fundação Oswaldo Cruz/Fiocruz); Desirée de Lemos Azevedo (Centro de Antropologia e Arqueologia Forense/Unifesp) e Lorrane Campos Rodrigues (Centro de Antropologia e Arqueologia Forense/Unifesp) com as pesquisadoras May-ek Querales, doutora em antropologia social, pesquisadora do tema das migrações forçadas e sua relação com o desaparecimento de pessoas no México, atualmente, compõe a Assembléia de Coordenação do Grupo de Investigaciones en Antropología Social y Forense (GIASF); e, Blanca Martínez, defensora de direitos humanos, diretora do Centro Diocesano para los Derechos Humanos Fray Juan de Larios, e assessora das Fuerzas Unidas por Nuestros Desaparecidos en Coahuila y México.
Racionalidades educacionais (pós-) pandêmicas: atlas 2022
Authors:   Universidade de São Paulo. Faculdade de Educação, Aquino Julio Groppa
Published: November 2024

O presente trabalho encerra a trilogia Racionalidades Educacionais (Pós-)Pandêmicas, resultante da pesquisa iniciada, durante 2022, no Programa Ano Sabático do Instituto de Estudos Avançados da Universidade de São Paulo. O estudo, em seus três volumes, devotou-se a perspectivar as racionalidades em circulação no campo educacional brasileiro durante o triênio 2020-2022, depois da eclosão da pandemia de COVID-19. Neste trabalho, o ano de 2022 foi focalizado, sendo que os dois anos anteriores foram contemplados nos volumes antecedentes. É necessário frisar que o leitmotiv temático do estudo não foi a crise sanitária da COVID-19, mas seus efeitos sobre o ideário educacional. Interessavam-nos menos iniciativas pedagógicas x ou y em face da pandemia e mais as reverberações do fenômeno sobre o éthos pedagógico como um todo. Tratou-se, assim, de escrutinar as discussões que despontaram ou ganharam força quando o campo pedagógico-escolar teve de se haver com um acontecimento sócio-histórico sem precedentes. É no encalço desse desafio que a pesquisa, como um todo, se postulou. As bases teóricas do estudo foram sumarizadas nas apresentações dos volumes anteriores, de modo que não serão retomadas aqui. No ponto de vista empírico, o estudo voltou-se à produção acadêmica brasileira da área de educação, no quadrante dos periódicos acadêmicos (a discriminação dos periódicos e das instâncias responsáveis por eles encontra-se ao final do trabalho). A escolha de tal nicho discursivo como fonte exclusiva do estudo ancora-se no pressuposto de que se trata de um suporte documental tão caudaloso quanto estratégico, na medida em que opera como caixa de ressonância do que o campo fomentou no plano das ideias durante o triênio analisado. Ao mesmo tempo, partimos da premissa de que, dada sua circulação aberta, os periódicos firmam-se como vetor de indução de determinadas pautas discursivas no interior do mesmo campo.
Clinical Features and Outcomes of Pediatric
MYH7
‐Related Dilated Cardiomyopathy
Authors: de Frutos Fernando , Ochoa Juan Pablo , Webster Gregory , Jansen Mark , Remior Paloma , Rasmussen Torsten B. , Sabater‐Molina Maria , Barriales‐Villa Roberto , Girolami Francesca , Cesar Sergi , Fuentes‐Cañamero M. Eugenia , Alvarez García‐Rovés Reyes , Wahbi Karim , Limeres Javier , Kubanek Milos , Slieker Martijn G. , Sarquella‐Brugada Georgia , Abrams Dominic J. , Dooijes Dennis , Domínguez Fernando , Garcia‐Pavia Pablo ,   for the European Genetic Cardiomyopathies Initiative Investigators
Published: November 2024

Background

Although genetic variants in
MYH7
are the most frequent cause of pediatric genetic dilated cardiomyopathy (DCM), there are no studies available describing this entity. We sought to describe clinical features, analyze variant location, and explore predictors of bad prognosis in pediatric
MYH7
‐related DCM.

Methods and Results

We evaluated clinical records from 44 patients (24 men; median age at diagnosis, 0.54 [interquartile range, 0.01–10.8] years) with pathogenic/likely pathogenic variants in
MYH7
diagnosed with DCM at pediatric age (<18 years) followed at 13 international centers. We also explored risk factors associated with a composite end point of end‐stage heart failure defined as heart transplantation or heart failure–related death. Twenty‐two patients (50%) were diagnosed at age <6 months, including 7 (16%) at birth. Left ventricular (LV) hypertrabeculation features were present in 15 (38%), particularly among patients with genetic variants in the head domain. After a median follow‐up of 6.1 years (interquartile range, 1.9–13.4), 15 patients (36%) required a heart transplant (n=14) or died due to end‐stage heart failure (n=1), 15 patients (36%) persisted with systolic dysfunction despite treatment, 12 (29%) had a significant increase in LV ejection fraction, and 2 were lost to follow‐up. Overall, end‐stage heart failure event rate was 25% at 5 years. New York Heart Association class III to IV (hazard ratio [HR], 7.67 [95% CI, 2.16–27.2];
P
=0.002) and LV ejection fraction ≤35% (HR, 4.00 [95% CI, 1.11–14.4];
P
=0.03) were the best predictors of bad prognosis.

Conclusions

Pediatric
MYH7
‐related DCM is characterized by early onset, frequent LV hypertrabeculation, and poor prognosis. Advanced New York Heart Association class and low LV ejection fraction emerged as predictors of end‐stage heart failure.
Experimental Manipulation of the Bilateral Posterior Parietal Cortex Strengthens Associative Memory in Healthy Participants: A Continuous Theta-burst Stimulation
Authors: Cheng Lulu , Li Xinzhao , Hao Zeqi , Li Jing , Zhao Mengqi , Zhan Linlin , Li Mengting , Gu Haiyan , Jia Xize
Published: November 2024

To test whether targeting left and right posterior parietal cortex (PPC) with continuous theta-burst stimulation (cTBS) in healthy adults would strengthen associative memory (AM) performance. This study consisted of two experiments (a behavioral experiment and a formal experiment during each of the two experimental sessions). In Experiment 1, 18 adults (one male, ages = 22.83 ± 3.92 years) were included in the behavioral phase and 18 adults (seven male, ages = 40.11 ± 12.27 years) in the stimulation phase. There were 120 neutral facial images paired with 120 two-character nouns and then divided into six test versions (10 male faces and 10 female faces paired with 20 different nouns were considered as one version). In the behavioral experiment, participants were tested by six-version tests to assess memory materials, and in the formal experiment, participants' face–word AM performance was measured by certified tests based on a cued recall paradigm. Furthermore, 30 adults (seven male, ages = 20.97 ± 1.85 years) and 15 adults (five male, ages = 22.27 ± 1.29 years) participated in Experiment 2, respectively. Stimuli and procedure were the same as in Experiment 1, but the AM test was based on a forced-choice paradigm. Experiment 1 did not yield anticipated outcomes; Experiment 2 showed that cTBS of left and right PPC strengthened the AM performance compared with the control condition. In conclusion, cTBS to left and right PPC improved AM in healthy adults, which provided further experimental evidence for strengthening AM by cTBS.
Updated Taxonomy of Chinese Phlomoides: description of three newly recorded species and their systematic placement
Authors: ZHAO YUE , LAZKOV GEORGII A. , TURGINOV ORZIMAT T. , SALMAKI YASAMAN , ZHOU XIN-XIN , LI WEN-JUN , XIANG CHUN-LEI
Published: November 2024

Phlomoides iliensis, P. dshungarica and P. rotala, previously known only from Kazakhstan, are newly recorded in Xinjiang Uygur Autonomous Region, China. Molecular phylogenetic analyses using eight plastid DNA markers (atpB-rbcL, psbA-trnH, rpl16, rpl32-trnL, rps16, trnK, trnL-trnF, trnT-trnL) revealed that these three species are nested within Clade VI, with their relationships to similar or allied species discussed. This study increases the total number of Phlomoides species in China to 64. In addition, diagnostic characters, updated morphological descriptions, detailed illustrations, and a key that encompasses all 16 Phlomoides species found in the Xinjiang Uygur Autonomous Region are provided.
Impatiens mogangensis (Balsaminaceae), a new species from Yunnan, China
Authors: LYU LING , HUANG QING , SHUI YU-MIN , ZHANG JIN-GUO , CHEN WEN-HONG
Published: November 2024

Impatiens mogangensis, a new species discovered in the limestone region of southeast Yunnan, China, is described and illustrated. Based on characteristics such as extremely contracted pedicels, connate lateral united petals, and four-locular ovary, this species is classified within Impatiens sect. Semeiocardium. Within the section, I. mogangensis resembles I. morsei morphologically in the white-tipped, yellow and brown-striated flowers, obconic capsule, and brick-shaped seeds. Additionally, I. mogangensis is similar to I. bonii in their reflexed lower lobes of lateral united petals, obconic capsules, and brick-shaped seeds, but can be distinguished from I. morsei and I. bonii by having 5–7 pairs of lateral leaf veins, serrate leaf margins, and falcate lower lobes of the lateral united petals. Besides, I. mogangensis is confined to the limestone region in Mogang village of south-eastern Yunnan and does not overlap with the distribution of I. morsei and I. bonii. In conclusion, the new species we proposed is a morphological transitional type between I. morsei and I. bonii respectively with their endemic geographical distributions.
Investigating Oxide Formation and Growth in Inconel 718 Oxidized at High Temperatures
Authors: Ha Seong-Ho , Choi Jaegu , Kim Dong-Hyuk
Published: November 2024

In this study, oxide formation and growth in Inconel 718 oxidized at 1,000 °C and 1,100 °C were investigated using scanning electron microscopy and phase diagrams including oxygen partial pressure. Inconel 718 showed significantly improved oxidation resistance compared to that
of Nickel 201 with no alloying elements. The oxide layer of Inconel 718 consisted of a Cr-rich upper layer and Nb-rich lower layer. In addition, the oxide layer of Inconel 718 at 1,100 °C was significantly Ti-enriched. NiO crystals were found to be oxidized on Nickel 201, which were grown
long in the thickness direction, whereas the oxide layer composed of fine and equiaxed Cr2O3 crystals was observed in the case of Inconel 718. Based on the phase diagram plotted for the oxygen partial pressure, primary Cr2O3, secondary Nb2O,
and Nb2O5 were followed by spinel oxide formation in Inconel 718.
Molecular Interactions of Barium Oxide Nanofluid at Different Temperatures
Authors: Prakash P. , John J. Catherine Grace , Jeevaraj A. Kingson Solomon , Hashem Mohamed , Yahia M. E.
Published: November 2024

In many industrial and scientific applications, low heat transfer is one of the main issues with heat exchanger fluids. This covers refrigeration systems, heat exchangers in solar hot water panels, high-power transformers, and engine cooling. In order to cope with these problems in
the thermal sector, nanofluids have the potential to be highly significant heat exchanger materials. Barium oxide nanofluids have a high thermal conductivity and are inexpensive, making them ideal for a wide range of thermal applications. Hytherm600 nanofluids based on barium oxide are synthesised
and presented in this study. Dispersed throughout the base fluid, Hytherm600, are BaO nanoparticles at varying concentrations (0.001–0.006 g). The FT-IR is used to characterise the BaO:Hytherm600 nanofluids. The ultrasonic velocity is computed between 300 K and 323 K for a range of concentrations
and temperatures. Analysing a number of acoustical parameters, such as compressibility, free length, specific impedance, molar compressibility, Rao’s constant, relaxation time, internal pressure, free energy, and free volume, can help explain the behaviour of ultrasonic velocity. These
acoustical parameters were calculated from observed values of ultrasonic velocity and density using standard equations and relations related to the molecular interactions among the particles and the base fluid. Variations in ultrasonic velocity and other computed acoustic characteristics are
utilised to assess the heat conductivity of BaO:Hytherm600 nanofluids since adding a modest volume percent of nanoparticles to a base fluid greatly increases its thermal conductivity.
Prevention of occlusal caries using VanishTM XT: an 18-month follow-up randomized clinical trial
Authors: Baik Alaa , Alamoudi Najlaa , Felemban Osama , El-Housseiny Azza , Almabadi Eman , Baik Khadijah , Altuwirqi Amani , Masoud Ibrahim
Published: November 2024

Aim

To evaluate the effectiveness of a light curable resin-modified glass ionomer varnish (VanishTM XT) in the prevention of occlusal caries compared to topical fluoride varnish in newly erupted first permanent molars over 18 months.

Methods

A randomized controlled clinical trial was conducted using a split-mouth design. A total of 53 participants aged 6–9 years with 97 pairs of caries-free newly erupted first permanent molars were enrolled in the study. Each molar in the pair was randomly assigned either to the experimental group, which received the VanishTM XT Extended Contact Varnish, or to the control group, which received topical fluoride varnish (VanishTM 5% Sodium Fluoride White Varnish). Follow-ups were performed at 6, 12, and 18 months to evaluate dental caries development.

Results

At the 6-month follow-up, caries development was significantly higher in the control group (7.8%) than that in the experimental group (0%) (P = 0.031). At the 12-month follow-up, significantly (P = 0.012) more occlusal caries developed in the control group (12.2%) compared to the experimental group (1.2%). At the 18-month follow-up, significantly (P = 0.002) more occlusal caries developed in the control group (14.3%) compared to the experimental group (1.1%).

Conclusion

Compared to fluoride varnish, VanishTM XT was significantly more effective in preventing caries on the occlusal surfaces of newly erupted first permanent molars at 6, 12, and 18 months.

Trial registration

Registration number at ClinicalTrials.gov: NCT04579536 on 08/10/ 2020, retrospectively registered.
What can be done to ease the transition to becoming a new paediatric registrar?
Authors: Long Sarah A. , Alam Shouja M. A. , Allery Lynne A.
Published: November 2024

Background

The transition period of becoming a new paediatric registrar has limited study. Consequently, the learning needs of such trainees are unclear including educational interventions that may improve the process. This qualitative study examined the negative and positive experiences of transitioning paediatric trainees to identify learning needs and subsequently derive educational interventions that are perceived to ease transition.

Methods

This was a qualitative study of semi-structured interviews with Wales deanery paediatric speciality trainees 3 and 4 (ST3 and ST4) undergoing transition to registrar. Participants were asked to recall one positive and one negative experience during transition using the critical incident technique (CIT). Transcribed responses were coded and thematically analysed and categorised into higher and lower order themes.

Results

Six paediatric trainees were interviewed for the study. A total of eighteen codes relating to learning needs were identified and dichotomised into two higher order themes; clinical skills, and leadership and management skills, with further exploration into lower order themes. Clinical skills included child protection procedures, difficult communication with relatives, emergencies, childhood death, difficult procedures, tertiary level neonatal care, managing family anxiety and expectations, dealing with uncertainty and running clinics. Leadership and management skills involved clinical decision making by new registrars, leading ward rounds, managing workload, leading a team and supervising junior colleagues. For educational interventions, sixty-seven initial codes were recorded and combined to form thirty-two lower order themes under six higher order themes. This outlined six educational interventions perceived to ease the transition to the registrar grade including; acting up whilst a senior house officer, seniors providing feedback, seniors providing support, staff providing support, trainee familiarisation with the new registrar placement and trainees maximising SHO learning opportunities.

Conclusions

This study provided a grounding upon which further research can be based, by identifying learning needs within the themes of clinical skills and leadership and management skills, as well as providing further descriptions of perceived beneficial educational interventions that ease transition to paediatric registrar. Furthermore, this study proposes evidence-based recommendations involving five key stakeholders to improve the experience of transition for future trainees. These stakeholders include; trainees, seniors, educators, nursing staff and rota coordinators.
Patient-centered care in pulmonary fibrosis: access, anticipate, and act
Authors: Hofman Delian E. , Magrì Tonia , Moor Catharina C. , Richeldi Luca , Wijsenbeek Marlies S. , Waseda Yuko
Published: November 2024

Comprehensive care integrates individual patient needs and is highly valued for patients with pulmonary fibrosis (PF). The importance of a patient-centered care approach is rooted in the unpredictable progressiveness of the disease course in PF. The respiratory impairment associated with PF has a major impact on the quality of life for both patients and their caregivers. We believe that prioritizing patient preferences could improve the shared decision making process and may ultimately lead to better health outcomes. Despite the growing emphasis for this approach, it remains challenging to adopt it in clinical practice. In this review, we propose the comprehensive Triple A Care Model, consisting of the domains Access, Anticipate, and Act, which emphasizes core elements of patient-centered care for patients with PF. We will provide an overview of the unmet needs in care for patients with PF and elaborate on the current methods for delivering patient-centered care. The latest insights into symptom management and supportive measures and several approaches to improving access to care are discussed, in line with the most recent guidelines.
The role of economic evaluation in modelling public health and social measures for pandemic policy: a systematic review
Authors: Rossiter Shania , Howe Samantha , Szanyi Joshua , Trauer James M. , Wilson Tim , Blakely Tony
Published: November 2024

Background

Dynamic transmission models are often used to provide epidemiological guidance for pandemic policy decisions. However, how economic evaluation is typically incorporated into this technique to generate cost-effectiveness estimates of pandemic policy responses has not previously been reviewed.

Methods

We systematically searched the Embase, PubMed and Scopus databases for dynamic epidemiological modelling studies that incorporated economic evaluation of public health and social measures (PHSMs), with no date restrictions, on 7 July 2024.

Results

Of the 2,719 screened studies, 51 met the inclusion criteria. Most studies (n = 42, 82%) modelled SARS-CoV-2. A range of PHSMs were examined, including school closures, testing/screening, social distancing and mask use. Half of the studies utilised an extension of a Susceptible-Exposed-Infectious-Recovered (SEIR) compartmental model. The most common type of economic evaluation was cost-effectiveness analysis (n = 24, 47%), followed by cost-utility analysis (n = 17, 33%) and cost–benefit analysis (n = 17, 33%).

Conclusions

Economic evaluation is infrequently incorporated into dynamic epidemiological modelling studies of PHSMs. The scope of this research should be expanded, given the substantial cost implications of pandemic PHSM policy responses.
Deciphering the microbial communities in ticks of Inner Mongolia: ecological determinants and pathogen profiles
Authors: Li Chunfu , Ma Rui , Gao Ai , Jiang Na , Sang Chunli , Zhang Yanli , Tian Haoqiang , Li Jian , Hu Wei , Feng Xinyu
Published: November 2024

Background

Ticks are vectors of numerous pathogens, with their bacterial composition, abundance, diversity, and interaction influencing both their growth and disease transmission efficiency. Despite the abundance of ticks in Inner Mongolia, China, comprehensive data on their microbial communities are lacking. This study aims to analyze the microbial communities within ticks from Inner Mongolia to inform innovative control strategies for interrupting pathogen transmission.

Methods

Tick samples were collected from animals and vegetation in multiple locations across Inner Mongolia and stored at − 80 °C. Ticks were identified using morphological keys and molecular biology methods. Full-length 16S rRNA gene sequencing was performed on collected samples. Bacterial community composition and diversity were mainly analyzed using bioinformatic tools such as QIIME, phyloseq, and DESeq2. Alpha diversity was assessed using Chao1, ACE, and Shannon indices, while beta diversity was evaluated using Bray-Curtis dissimilarity matrices. LEfSe analysis was applied to identify taxa associated with ecological and biological variables.

Results

A total of 5,048,137 high-quality read counts were obtained, forming an average of 789.3 OTUs per sample. Proteobacteria, Firmicutes, and Bacteroidetes were the most dominant phyla. Bacterial community composition varied significantly with geography, with Dermacentor nuttalli showing a higher abundance of Rickettsia in Xilingol League, while other regions had different dominant genera. The microbial community also differed based on the feeding status of ticks. Additionally, the microbiota of engorged ticks showed organ specificity. Pathogen detection efforts revealed the presence of nine pathogens across all three tick species. D. nuttalli was found to carry a significantly higher burden of pathogenic bacteria, making it the most potentially threatening tick species in Inner Mongolia.

Conclusions

The study highlights significant variations in tick microbiomes influenced by geographic location, feeding status, and tick species. It underscores the importance of enhancing tick and tick-borne disease surveillance in Inner Mongolia for early detection and control of emerging pathogens.

Graphical Abstract
Real-time modeling of transient crustal deformation through the quantification of uncertainty deduced from GNSS data
Authors: Ohno Keitaro , Ohta Yusaku , Takamatsu Naofumi , Munekane Hiroshi , Iguchi Masato
Published: November 2024

We propose a new method for real-time uncertainty monitoring of earthquake and volcano source models using data from the global navigation satellite system (GNSS) and explore its application concerning observation station placement. The Geospatial Information Authority of Japan operates two main types of GNSS earth observation network system (GEONET) coordinates for crustal deformation monitoring on different time scales: post-processing analysis values and real-time GEONET analysis system for rapid deformation monitoring (REGARD). REGARD uses the Markov Chain Monte Carlo (MCMC) method termed real-time automatic uncertainty estimation of a coseismic single rectangular model using GNSS data (RUNE) for single rectangular fault model estimation to handle uncertainty. Thus far, no GNSS monitoring system can automatically detect transient crustal deformation events, such as volcanic activity and earthquake swarms, on timescales of a day or less. We extended RUNE and developed a core program for a new monitoring system for earthquake and volcanic source models and their uncertainties. Our program achieved automatic and stable MCMC utilization for rectangular fault, dike, Mogi, and spheroid models by increasing the computational speed, improving search efficiency, and adjusting hyperparameters. The program automatically determines the standard deviation of the likelihood function assuming a normal distribution with weights for each observation station. The calculation time was within 15 s for 1 × 106 samples on a standard 1U server. We assessed the reliability of the developed method using synthetic and observed GNSS data from the 2015 Sakurajima volcanic event. The results were consistent with the assumed model and previous studies and indicated an advantage in automatically quantifying uncertainty in a short computation time. Based on MCMC samples, we developed a new visualization algorithm to indicate areas on a map in which the number of observation stations should be expanded. We assessed the reliability using data from the 2023 Noto Peninsula earthquake [Mj 6.5]. The results indicate that the algorithm is helpful in studying the placement of stations. The above model extensions and their application are essential to achieve a rapid quantitative understanding of disaster events near urban areas and for utilizing this information in emergency response activities.

Graphical Abstract
Investigating the hypothermic effects of fluoroquinolone antimicrobials on non-bacterial fever model mice
Authors: Hara Ryohei , Taguchi Kazuaki , Ogino Hiromi , Okamoto Yuko , Enoki Yuki , Kizu Junko , Hori Seiji , Matsumoto Kazuaki
Published: November 2024

Background

Fluoroquinolone (FQ) antimicrobials have antipyretic effects during the treatment of bacterial infections; however, it is not clear whether these are due to their antimicrobial activities or their hypothermic effects. In this study, we investigated the hypothermic effects of FQ antimicrobials (ciprofloxacin [CPFX], gatifloxacin [GFLX], and levofloxacin [LVFX]) on fever by evaluating rectal body temperature changes in a mouse model of non-bacterial fever.

Methods

CPFX, GFLX, and LVFX were administered intraperitoneally to non-bacterial fever model mice induced by yeast. Rectal body temperature was measured up to 180 min after administration.

Results

A decrease in rectal body temperature of up to 1.2 °C for CPFX, 3.4 °C for GFLX, and 1.0 °C for LVFX was observed. The decrease in temperature was induced by an increase in the plasma concentration of FQ antimicrobials, suggesting that they are responsible for the temperature reduction. Focusing on glucocorticoids, one thermoregulation mechanism, we investigated the substances responsible for the reduction in rectal body temperature induced by FQ antimicrobials. Aminoglutethimide (an inhibitor of glucocorticoid production) were premedicated, followed by intraperitoneal administration of GFLX in the yeast-induced fever mouse model, resulting in attenuated GFLX-induced hypothermic effects.

Conclusions

These results suggest that certain antipyretic effects of CPFX, GFPX, and LVFX during fever may contribute to their hypothermic effects; certain mechanisms are glucocorticoid-mediated.
Evaluating distributed acoustic sensing for crosswell seismic surveys with helical and linear fibers using conventional P-, SH-, and SV-wave sources
Authors: Koedel U. , Stork A. L. , David A. , Fechner T.
Published: November 2024

Seismic borehole tomography with standard seismic sources and receivers provides higher-resolution results compared to alternative conventional seismic surveys. The development of distributed acoustic sensing (DAS) for seismic surveys offers practical advantages over conventional sensors, such as higher spatial resolution, repeatable measurements, and time savings. This study details the use of DAS in conjunction with conventional seismic sources at the Svelvik CO2 Field Lab to conduct P-, SH-, and SV-wave crosswell surveys, comparing data obtained from helically wound and linear DAS fibers to evaluate their suitability for crosswell measurements. The use of such controlled active sources allows the generation of controlled, high-energy acoustic signals with defined characteristics that allow noise to be separated, resulting in cleaner and more reliable DAS data for further processing. The P-wave survey provided the best DAS response, and signals were recorded the full length of the borehole (approximately 100 m). The variations in signal-to-noise ratio (S/N) with incidence angle between DAS data sets from different cables indicate that it may be useful to record data on linear and helically wound cable for crosswell surveys to ensure the best P-wave response at source-receiver paths at the same depth. However, for SV-wave surveys, a linear fiber produces higher S/N data. Fluctuations in data quality are observed along the borehole due to differences in cable coupling. SH waves are recorded with low S/N on the DAS, as were the conventional data. Overall, wave arrival times in the DAS data are consistent with conventional data. The comparisons in this study show that good quality crosswell DAS data can be obtained for P- and SV-wave sources, thus providing repeatable, cost-effective SV measurements for time-lapse crosswell tomographic surveys.
Reviews
Authors: Aitken Julie
Published: November 2024

Understanding Environmental Pollution, fourth edition, by Marquita K. Hill, 2020
Metabolic dysfunction in severe mental illness: updates on prevalence, aetiology and treatment options
Authors: Needham Nicole , Kamenská Ivana , Meadowcroft Ben , Brown Rachel , Grossi Helen
Published: November 2024

Metabolic dysfunction is an established phenomenon in people with severe mental illness (SMI), and it has a higher prevalence than in the general population. It is associated with increased morbidity and mortality, and effective recognition and management are essential to enable good psychiatric care. Despite widespread awareness of this disparity for several decades, health outcomes continue to worsen, highlighting the need for more effective preventive and treatment measures. This article outlines the risk factors that contribute to metabolic dysfunction in this population, including genetic, environmental and pharmacological factors, and considers underlying metabolic pathophysiological processes as part of SMI itself. To aid discussions with patients, recognition and interpretation of metabolic risk factors are outlined, together with mitigating strategies. Novel areas of uncertainty are discussed, including the use of a ketogenic diet. This article advocates use of the term ‘metabolic psychiatry’, to increase awareness of the significant overlap between psychiatric illness and metabolic dysfunction.