bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of inorganic and organic pollutants from a Belgian wastewater treatment plant on adjacent surface and groundwaters
Authors: Luo Mingyue , Su Yiqi , Vandeputte Delphine Jenny , Jia Yuwei , Li Guanlei , Baeyens Willy , Huysmans Marijke , Elskens Marc , Gao Yue
Published: January 2024

Under the pressure of global droughts and water shortage, it is essential to evolve toward a sustainable and robust water system. One possible avenue is the maximum reuse of treated wastewater, but the quality of which determines its reuse. Therefore, inorganic (Cd, Pb, Cr, Ni, Cu, and As) and organic (xenoestrogens and polycyclic aromatic contaminants, PACs) contaminants were monthly monitored in an effluent of the wastewater treatment plant (WWTP), the surrounding surface waters and the local groundwater in Belgium. Dissolved and particulate concentrations of inorganic contaminants in these water bodies were analyzed. In addition, Diffusive Gradients in Thin-films (DGT) was used in situ to obtain bioavailable metal fractions. In the WWTP effluent and surface waters, only Ni exceeds the Annual Average-Environmental Quality Standard (AA-EQS), while in the groundwater, dissolved As was the predominant element. Moreover, in the surface and effluent waters the highest lability degrees were observed for Cd and Ni. The concentrations of these metal species in the effluent water were lower than in the other water bodies. Micro-organic pollutants, xenoestrogens and PACs were analyzed by dual Estrogen and Aryl hydrocarbon Receptor - Chemical Activated LUciferase gene eXpression (ER & AhR-CALUX) assays. Since the annual averaged (AA) bioequivalent concentration of E2 (0.18 ng/L) is below the AA-EQS standard (0.4 ng/L), and the bioequivalent concentration of benzo[a]pyrene never exceeded the maximum admissible concentration (MAC), the reclamation and reuse of treated wastewater for groundwater replenishment and agricultural irrigation should pose no environmental problems, at least in a short-term.
Inclusion properties for classes of $$p-$$valent functions associated with linear operator
Authors: Aouf M. K. , Mostafa A. O. , El-Hawsh G. M.
Published: January 2024

The purpose of the present paper is to introduce subclasses of $$p-$$

p
-

valent functions defined by linear operator. Inclusion relationships for functions in these subclasses are discussed.
Linear integral operators on $$L_p$$ spaces representing polynomial covariance type commutation relations
Authors: Djinja Domingos , Silvestrov Sergei , Tumwesigye Alex Behakanira
Published: January 2024

In this work, we present methods for constructing representations of polynomial covariance type commutation relations $$AB=BF(A)$$

A
B
=
B
F
(
A
)

by linear integral operators in Banach spaces $$L_p$$

L
p

. We derive necessary and sufficient conditions on the kernel functions for the integral operators to satisfy the covariance type commutation relation for general polynomials F, as well as for important cases, when F is arbitrary affine or quadratic polynomial, or arbitrary monomial of any degree. Using the obtained general conditions on the kernels, we construct concrete examples of representations of the covariance type commutation relations by integral operators on $$L_p$$

L
p

. Also, we derive useful general reordering formulas for the integral operators representing the covariance type commutation relations, in terms of the kernel functions.
Exploring what makes learning meaningful for postgraduate business students in higher education
Authors: Zeivots Sandris , Tyrrell Jessica , Wardak Dewa
Published: January 2024

While research exists on what constitutes meaningful learning, our study reveals the term meaningful is an ill-defined concept that is interpreted in multiple ways, often from a teacher-centric perspective. Less is known about what constitutes meaningfulness in the context of higher education, particularly in business education. This qualitative study seeks to identify postgraduate student perspectives on what is meaningful in higher education to inform the design of authentic and transformative learning experiences. Focus groups were conducted to gain insights into students’ most meaningful learning experiences across four postgraduate business subjects. We conducted a thematic analysis of the student data by inductively coding the transcripts and comments. Students derived the most value from learning experiences that incorporated real-world connections, social encounters, or productive challenges. We also found that students’ discussions of meaningfulness were relatively superficial, suggesting that postgraduate students may not be primed to consider meaningfulness in relation to their learning. We thus problematise the term meaningful and conclude by proposing ‘learning highs’ as a new tentative conceptual frame for future research identifying learning situations in which meaningful experiences occur.
VERITE: a Robust benchmark for multimodal misinformation detection accounting for unimodal bias
Authors: Papadopoulos Stefanos-Iordanis , Koutlis Christos , Papadopoulos Symeon , Petrantonakis Panagiotis C.
Published: January 2024

Multimedia content has become ubiquitous on social media platforms, leading to the rise of multimodal misinformation (MM) and the urgent need for effective strategies to detect and prevent its spread. In recent years, the challenge of multimodal misinformation detection (MMD) has garnered significant attention by researchers and has mainly involved the creation of annotated, weakly annotated, or synthetically generated training datasets, along with the development of various deep learning MMD models. However, the problem of unimodal bias has been overlooked, where specific patterns and biases in MMD benchmarks can result in biased or unimodal models outperforming their multimodal counterparts on an inherently multimodal task, making it difficult to assess progress. In this study, we systematically investigate and identify the presence of unimodal bias in widely used MMD benchmarks, namely VMU-Twitter and COSMOS. To address this issue, we introduce the “VERification of Image-TExt pairs” (VERITE) benchmark for MMD which incorporates real-world data, excludes “asymmetric multimodal misinformation” and utilizes “modality balancing”. We conduct an extensive comparative study with a transformer-based architecture that shows the ability of VERITE to effectively address unimodal bias, rendering it a robust evaluation framework for MMD. Furthermore, we introduce a new method—termed Crossmodal HArd Synthetic MisAlignment (CHASMA)—for generating realistic synthetic training data that preserve crossmodal relations between legitimate images and false human-written captions. By leveraging CHASMA in the training process, we observe consistent and notable improvements in predictive performance on VERITE; with a 9.2% increase in accuracy. We release our code at: https://github.com/stevejpapad/image-text-verification
Third-Country Regime and Equivalence: The Swiss Perspective
Authors: Darbellay Aline
Published: January 2024

This paper discusses the role of the third-country regime and equivalence from the Swiss perspective. It provides an analysis of the evolution of the Swiss approach. The various reactions to EU developments have ranged from the attempt to implement a reciprocity principle, to the resort to unilateral recognition. An overarching purpose of the Swiss equivalence framework has consisted of the relentless pursuit of a competitiveness objective. Yet the decline of equivalence as a market access mechanism has led to favouring other market access routes. This paper concludes that the recent reforms have initiated a roadmap towards an increasing autonomy of Swiss financial market law.
Deep Q-learning with hybrid quantum neural network on solving maze problems
Authors: Chen Hao-Yuan , Chang Yen-Jui , Liao Shih-Wei , Chang Ching-Ray
Published: January 2024

Quantum computing holds great potential for advancing the limitations of machine learning algorithms to handle higher dimensions of data and reduce overall training parameters in deep learning (DL) models. This study uses a trainable variational quantum circuit (VQC) on a gate-based quantum computing model to investigate the potential for quantum benefit in a model-free reinforcement learning problem. Through a comprehensive investigation and evaluation of the current model and capabilities of quantum computers, we designed and trained a novel hybrid quantum neural network based on the latest Qiskit and PyTorch framework. We compared its performance with a full-classical CNN with and without an incorporated VQC. Our research provides insights into the potential of deep quantum learning to solve a maze problem and, potentially, other reinforcement learning problems. We conclude that reinforcement learning problems can be practical with reasonable training epochs. Moreover, a comparative study of full-classical and hybrid quantum neural networks is discussed to understand these two approaches’ performance, advantages, and disadvantages to deep Q-learning problems, especially on larger-scale maze problems larger than 4$$\times $$
×
4.
Accuracy Analysis for Explicit-Implicit Finite Volume Schemes on Cut Cell Meshes
Authors: May Sandra , Laakmann Fabian
Published: January 2024

The solution of time-dependent hyperbolic conservation laws on cut cell meshes causes the small cell problem: standard schemes are not stable on the arbitrarily small cut cells if an explicit time stepping scheme is used and the time step size is chosen based on the size of the background cells. In May and Berger (J Sci Comput 71: 919–943, 2017), the mixed explicit-implicit approach in general and MUSCL-Trap (monotonic upwind scheme for conservation laws and trapezoidal scheme) in particular have been introduced to solve this problem by using implicit time stepping on the cut cells. Theoretical and numerical results have indicated that this might lead to a loss in accuracy when switching between the explicit and implicit time stepping. In this contribution, we examine this in more detail and will prove in one dimension that the specific combination MUSCL-Trap of an explicit second-order and an implicit second-order scheme results in a fully second-order mixed scheme. As this result is unlikely to hold in two dimensions, we also introduce two new versions of mixed explicit-implicit schemes based on exchanging the explicit scheme. We present numerical tests in two dimensions where we compare the new versions with the original MUSCL-Trap scheme.
Experimental sensing quantum atmosphere of a single spin
Authors: Zhu Kehang , Yang Zhiping , Jiang Qing-Dong , Chai Zihua , Li Zhijie , Zhao Zhiyuan , Wang Ya , Shi Fazhan , Duan Chang-Kui , Rong Xing
Published: January 2024

Understanding symmetry-breaking states of materials is a major challenge in the modern physical sciences. Quantum atmosphere proposed recently sheds light on the hidden world of these symmetry broken patterns. Yet, no experiment has been performed to demonstrate its potential. In our experiment, we prepare time-reversal-symmetry conserved and broken quantum atmosphere of a single nuclear spin and successfully observe their symmetry properties. Our work proves in principle that finding symmetry patterns from quantum atmosphere is conceptually viable. It also opens up entirely new possibilities in the potential application of quantum sensing in material diagnosis.
Better-than-chance prediction of cooperative behaviour from first and second impressions
Authors: Schniter Eric , Shields Timothy W.
Published: January 2024

Could cooperation among strangers be facilitated by adaptations that use sparse information to accurately predict cooperative behaviour? We hypothesise that predictions are influenced by beliefs, descriptions, appearance and behavioural history available for first and second impressions. We also hypothesise that predictions improve when more information is available. We conducted a two-part study. First, we recorded thin-slice videos of university students just before their choices in a repeated Prisoner's Dilemma with matched partners. Second, a worldwide sample of raters evaluated each player using videos, photos, only gender labels or neither images nor labels. Raters guessed players’ first-round Prisoner's Dilemma choices and then their second-round choices after reviewing first-round behavioural histories. Our design allows us to investigate incremental effects of gender, appearance and behavioural history gleaned during first and second impressions. Predictions become more accurate and better-than-chance when gender, appearance or behavioural history is added. However, these effects are not incrementally cumulative. Predictions from treatments showing player appearance were no more accurate than those from treatments revealing gender labels and predictions from videos were no more accurate than those from photos. These results demonstrate how people accurately predict cooperation under sparse information conditions, helping explain why conditional cooperation is common among strangers.
Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology
Authors: Elemam Noha M. , Mekky Radwa Y. , Rashid Gowhar , Braoudaki Maria , Youness Rana A.
Published: January 2024

The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion and metastasis. Taking a closer look at the tumour-immune microenvironment, a complex network and crosstalk between infiltrating immune cells and cancer cells mediated by cytokines, chemokines, exosomal mediators and shed ligands are present. Cytokines such as interleukins can influence all components of the tumour microenvironment (TME), consequently promoting or suppressing tumour invasion based on their secreting source. Interleukin-10 (IL-10) is an interlocked cytokine that has been associated with several types of malignancies and proved to have paradoxical effects. IL-10 has multiple functions on cellular and non-cellular components within the TME. In this review, the authors shed the light on the regulatory role of IL-10 in the TME of several malignant contexts. Moreover, detailed epigenomic and pharmacogenomic approaches for the regulation of IL-10 were presented and discussed.
The relationship between caffeine and its metabolites and bone mineral density in postmenopausal women: a cross-sectional analysis from the NHANES database
Authors: Liao Sheng , Zhou Jianhong , Chen Hui , Wei Wei , Ye Feng , Zhang Yidong , Zhang Zhongrong
Published: January 2024

We aim to explore the association between caffeine and its metabolites and bone mineral density (BMD) in postmenopausal women. Data of 4286 postmenopausal women were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2009–14 in this cross-sectional study. Weighted linear regression and stepwise regression analyses were used to screen the covariates. Weighted univariate and multivariate linear regression analyses were used to explore the associations between caffeine and its metabolites and BMD. The evaluation index was estimated value (β) with 95 % confidence intervals (CIs). We also explored these relationships in age subgroups. The median BMD level among the eligible women was 0⋅7 gm/cm2. After adjusting for covariates including age, body mass index (BMI), fat intake, Calcium (Ca) supplements, diabetes mellitus (DM), angina pectoris, parental history of osteoporosis (OP), anti-osteoporosis therapy, poverty income ratio (PIR), vitamin D (VD) supplements, coronary heart disease (CHD), and previous fracture, we found that caffeine intake was not significantly related to the BMD reduction (β = 0, P = 0⋅135). However, caffeine metabolites, including MethyluricAcid3, MethyluricAcid7, MethyluricAcid37, Methylxanthine3, and Methylxanthine37, were negatively associated with the BMD (all P < 0⋅05). In addition, MethyluricAcid37 and Methylxanthine37 were negatively associated with BMD in females aged <65 years old, while MethyluricAcid3 and Methylxanthine3 were noteworthy in those who aged ≥65 years old. The roles of caffeine and its metabolites in BMD reduction and OP in postmenopausal women needed further exploration.
‘That’s Not Something That’s Necessarily on the Radar’: Educators’ Perspectives on Dysgraphia
Authors: Kalenjuk Elvira , Subban Pearl , Laletas Stella , Wilson Sue
Published: January 2024

This qualitative study focused on educators’ perspectives of teaching students with dysgraphia. Dysgraphia can be referred to as a specific learning disorder (SLD) in writing and includes difficulties with handwriting, spelling, and/or composition skills. To explore the educators’ experiences, an interpretative phenomenological analysis method was implemented. This involved generating semistructured interviews and locating key concepts from these interviews, in tandem with researcher reflections. The results indicated that educators developed their self-efficacy in supporting students with dysgraphia on the job, augmented by self-guided and external searches for information about dysgraphia. The participants described their colleagues as generally unable to provide them with dysgraphia-specific knowledge due to a lack of awareness of dysgraphia within schools. Two of the three educators pursued Multisensory Structured Language training, departing the classroom to work in private tuition. Three teachers offered strategies for supporting students with dysgraphia, such as explicit, systematic, scaffolded, and repetitive instruction coupled with assistive technologies or lined paper and slant boards. The study concluded that dysgraphia-specific professional learning, coupled with collective efficacy, could proactively build teachers’ capacity and self-efficacy in supporting dysgraphia within an inclusive education context. These measures would more aptly support students with dysgraphia to reach their potential.
Whither dominance? An enduring evolutionary legacy of primate sociality
Authors: Altschul Drew M.
Published: January 2024

This article discusses dominance personality dimensions found in primates, particularly in the great apes, and how they compare to dominance in humans. Dominance traits are seen in virtually all primate species, and these dimensions reflect how adept an individual is at ascending within a social hierarchy. Among great apes, dominance is one of the most prominent personality factors but, in humans, dominance is usually modeled as a facet of extraversion. Social, cultural, and cognitive differences between humans and our closest ape relatives are explored, alongside humanity’s hierarchical and egalitarian heritage. The basic characteristics of dominance in humans and nonhuman great apes are then described, alongside the similarities and differences between great apes. African apes live in societies each with its own hierarchical organization. Humans were a possible exception for some of our history, but more recently, hierarchies have dominated. The general characteristics of high-dominance humans, particularly those living in industrialized nations, are described. Dominance itself can be subdivided into correlated subfactors: domineering, prestige, and leadership. Various explanations have been posed for why dominance has declined in prominence within human personality factor structures, and several possibilities are evaluated. The value of dominance in personality research is discussed: dominance has links to, for instance, age, sex, aggression, self-esteem, locus of control, stress, health, and multiple socioeconomic status indicators. The piece concludes with recommendations for researchers who wish to assess dominance in personality.
‘The very term mensuration sounds engineer-like’: measurement and engineering authority in nineteenth-century river management
Authors: Dishington Rachel
Published: January 2024

Measurement was vital to nineteenth-century engineering. Focusing on the work of the Stevenson engineering firm in Scotland, this paper explores the processes by which engineers made their measurements credible and explains how measurement, as both a product and a practice, informed engineering decisions and supported claims to engineering authority. By examining attempts made to quantify, measure and map dynamic river spaces, the paper analyses the relationship between engineering experience and judgement and the generation of data that engineers considered to be ‘tolerably correct’. While measurement created an abstract and simplified version of the river that accommodated prediction, this abstraction had to be connected to and made meaningful in real river space despite acknowledged limitations to measuring practice. In response, engineers drew on experience gained through the measuring process to support claims to authoritative knowledge. This combination of quantification and experience was then used to support interventions in debates over the proper use and management of rivers. This paper argues that measurement in nineteenth-century engineering served a dual function, producing both data and expertise, which were both significant in underpinning engineering authority and facilitating engineers’ intervention in decision making for river management.
The Multidirectional Diaspora: Writing Chinese Migration History in a Time of Global Racial Reckoning
Authors: Zhou Taomo
Published: January 2024

In On not speaking Chinese, cultural studies scholar Ien Ang characterizes migrant scholars as ‘tactical interventionists’; instead of making counter-hegemonic claims, they usually bring out the contradictions and the violence inherent in all posited truths. In the spirit of this claim, I thought long and hard about how to make the best use of my connections to both worlds – my lived experience of growing up in China and my access to academic resources in English-language academia. As James Gethyn Evans will show in his essay in this roundtable, ‘decolonizing’ the field of Chinese history should involve the dual tasks of questioning the hegemonic narratives propagated by the People’s Republic of China (PRC) government and the concentration of knowledge production in the Global North. Without the participation of PRC-based scholars, the current ‘decolonization’ movement would become a Western enterprise just like colonization.
In vitro evaluation of nanocomposites of linseed mucilage and k-carrageenan loaded with Achyrocline satureioides nanoemulsion: a gradual-release candidate of antimicrobials for the treatment of bovine mastitis
Authors: Machado Gabriela Tasso Pinheiro , Ferreira Roberto Gabriel , Veleirinho Maria Beatriz , Honorato Luciana Aparecida , Ramos Roberta de Oliveira , Silva Marcos Antônio Segatto , Kuhnen Shirley
Published: January 2024

This research paper presents the development and evaluation of pioneering nanocomposites (NCs) based on the combination of k-carrageenan and linseed mucilage. When loaded with macela extract nanoemulsion they present an innovative approach for the sustained release of antimicrobial herbal constituents, specifically tailored for bovine mastitis treatment. The NCs, encompassing various ratios of k-carrageenan and linseed mucilage polymers (8:2, 7:3, and 5:5 w/w) with 1.25 mg of macela extract/g of gel, underwent in vitro assessment, emphasizing viscosity, degradation speed, release of herbal actives from macela nanoemulsion and antimicrobial activity. The NCs exhibited thermoreversible characteristics, transitioning from liquid at 60°C to a gel at 25°C. NCs allowed a gradual release of phenolic compounds, reaching approximately 80% of total phenolics release (w/v) within 72 h. NCs inhibited the growth of MRSA (ATCC 33592) until 8 h of incubation. No toxic effect in vitro of NCs was found on MAC-T cells. Thus, the developed materials are relevant for the treatment of bovine mastitis, especially in the dry period, and the data support future evaluations in vivo.
Zoonotic risks of pathogens from dairy cattle and their milk-borne transmission
Authors: Holzhauer Menno , Wennink Gerrit Jan
Published: January 2024

Dairy products are major sources of high-quality protein and bioavailable nutrients and dairy production contributes to local, regional and national-level economies. Consumption of raw milk and raw milk products does, however, carry a zoonotic risk, as does direct contact with cattle by farm husbandry staff and other employees. This review will mainly focus on the latter, and deal with it from the standpoint of a well-developed dairy industry, using the example of the Netherlands. With regard to dairy cattle, the main bacterial pathogens are Salmonella spp., Listeria monocytogenes and Leptospira hardjo as well as Brucella abortus and Chlamydia abortus. The main viral pathogens associated with dairy are Rift Valley fever virus, rabies virus, cowpox virus and vaccinia virus. The main parasitological infections are Echinococcus granulosis, Cryptosporidium parvum and Giardia duodenalis, however, the last mentioned have mainly swimming pools as sources of human infection. Finally ectoparasites such as lice and mites and Trichophyton verrucosum may affect employees. Some pathogens may cause health problems due to contamination. Bacterial pathogens of importance that may contaminate milk are Campylolobacter jejuni, Escherichia coli, Mycobacterium avium subsp. paratuberculosis, Leptospira hardjo and Salmonella typhimurium. Excretion of zoonotic viruses in milk is negligible in the Netherlands, and the endoparasite, Toxocara vitulorum is mainly found in suckling and fattening calves, whilst the risk in dairy cattle is limited. Excretion of transmissible spongiform encephalopathies (TSEs) or mycoses in milk are not expected and are, therefore, not of importance here.

Being aware of the risks and working according to hygiene standards can substantially limit zoonotic risks for employees. Additionally, diseased employees are advised to limit their contact with cattle and to indicate that they work with cattle when consulting a physician. To prevent zoonotic risks through excretion of pathogens in milk, standard hygiene measures are necessary. Further, using only pasteurised milk for consumption and/or processing of milk can considerably limit the risks. If these measures are not possible, well-constructed monitoring can be followed. Monitoring programmes already exist for pathogens such as for Salmonella spp., Leptospira hardjo and Mycobacterium avium subsp. paratuberculosis. For others, like Campylobacter jejuni and E. coli, programmes are not available yet as far as we know.
Global sociology and its discontents
Authors: Roudometof Victor
Published: January 2024

Sociology emerged in the course of Western modernization; its major classical-era statements are preoccupied with modernity and its impact on national societies. After decolonization, ‘Third World’ modernization paved the way for the notion of globalization. The sociology of globalization is a current specialty within US and European sociological associations. The promise of global sociology has been on the agenda of the International Sociological Association since at least 1990. At a deeper level, global sociology requires un-thinking the role of core concepts such as modernity or religion or society vis-à-vis their Western origins. Global Studies and post-colonial sociology, two of the most widely known research fields claiming global intent, are examined with respect to whether they provide adequate conceptual resources for global sociology. While the research agendas of both offer promising insights, inquiry suggests that both suffer from important drawbacks. The sociological tradition is now facing an impasse; fragmentation may persist, but other possibilities also exist. No grand solution is perhaps possible. A truly global sociology may eventually emerge from the original interpretations that develop from non-Western historical paths.
Percutaneous pulmonary valve implantation in a patient with a single pulmonary artery and distal narrowing
Authors: Szeliga Judyta , Moszura Tomasz , Góreczny Sebastian
Published: January 2024

Percutaneous pulmonary valve implantation is established as a safe and effective method of treating patients with disfunction of right ventricular outflow tract. Modifications of this method allow for an increasingly wider use of this less invasive treatment. We present a staged percutaneous pulmonary valve implantation into a single-branch pulmonary artery in a paediatric patient with tetralogy of Fallot after patch repair.
The Artist as a Subscription: Patching music as an artistic device
Authors: McConville Thomas
Published: January 2024

This article aims to explore the concept of patched/versioned musical works as creative ecologies. It identifies how the internet’s involvement in music creation and dissemination influences choices related to the release of such works. Throughout this writing, the author looks at the increasingly volatile structures surrounding recorded music in the early twenty-first century as a result of streaming platforms such as Spotify and video-based social media sites such as TikTok becoming the primary means for music consumption. It explores this volatility as a method for approaching the release of new music within dynamic musical ecosystems and looks at the growing art scene focusing on this way of working, drawing parallels between artistry and subscription-based services where content continually evolves over time.
Predictors of anemia in mothers and children in Uttar Pradesh, India
Authors: Larson Leila M , Thomas Tinku , Kurpad Anura V , Martorell Reynaldo , Hoddinott John , Adebiyi Victoria , Swaminathan Sumathi , Neufeld Lynnette M
Published: January 2024

Objective:

Anemia affects more than half of Indian women and children, but the contribution of its causes remains unquantified. We examined interrelationships between hemoglobin and nutritional, environmental, infectious, and genetic determinants of anemia in non-pregnant mothers and children in Uttar Pradesh (UP).

Design:

We conducted a cross-sectional survey of households in 25 districts of UP between October and December 2016. We collected socio-demographic data, anthropometry, and venous blood in 1238 non-pregnant mothers and their children. We analyzed venous blood samples for malaria, hemoglobin, ferritin, retinol, folate, zinc, vitamin B12, C-reactive protein (CRP), α1-acid glycoprotein (AGP), and β-thalassemia. We used path analysis to examine pathways through which predictors of anemia were associated with hemoglobin concentration.

Setting:

Rural and urban households in 25 districts of UP.

Participants:

Mothers 18-49 years and children 6-59 months in UP.

Results:

A total of 36.4% of mothers and 56.0% of children were anemic, and 26.7% of women and 44.6% of children had iron deficiency anemia. Ferritin was the strongest predictor of hemoglobin [β (95% CI) = 1.03 (0.80, 1.27) g/dL in women and 0.90 (0.68, 1.12) g/dL in children]. In children only, red blood cell folate and AGP were negatively associated with hemoglobin and retinol was positively associated with hemoglobin.

Conclusions:

Over 70% of mothers and children with anemia had iron deficiency, needing urgent attention. However, several simultaneous predictors of hemoglobin exist, including nutrient deficiencies and inflammation. The potential of iron interventions to address anemia may be constrained unless coexisting determinants are jointly addressed.
ENSO and NAO Linkage to Strong Volcanism and Associated Post‐Volcanic High‐Latitude Winter Warming
Authors: Dogar Muhammad Mubashar , Fujiwara Masatomo , Zhao Ming , Ohba Masamichi , Kosaka Yu
Published: January 2024

High‐latitude winter warming was observed following strong tropical volcanism, which has long been believed to be due to the volcanic‐induced positive North Atlantic Oscillation (NAO) phase. However, recent works argue that this warming is caused by El Niño–Southern Oscillation (ENSO) variability instead of volcanoes. Moreover, some studies further argue that El Niño and volcanoes work together to produce this post‐volcanic NAO winter warming. To better understand these arguments on post‐volcanic high‐latitude winter warming, we conducted ENSO‐preconditioned volcanic experiments. Our simulations strongly suggest that the post‐eruption Eurasian winter warming is caused by a post‐eruption positive NAO phase and not by coexisting ENSO‐preconditioned variability. Additionally, we find that the El Niño‐preconditioned volcanic eruption enhances the El Niño phase; however, the neutral and La Niña‐preconditioned eruptions do not lead to an ENSO–like response. These findings are helpful to better understand volcanic‐induced circulation impacts and have important implications for the interpretation of model results and post‐volcanic prediction.
Ensemble Bayesian Model Averaging Projections of Wind‐Speed Extremes for Wind Energy Applications Over China Under Climate Change
Authors: Zhao Xiaohu , Huang Guohe , Lu Chen , Li Yongping , Ren Jiayan
Published: January 2024

Wind energy has grown rapidly in recent years as a measure to control carbon emissions and mitigate climate change. Extreme wind can damage wind turbines, cause losses to wind power plants, limit economic benefits of wind energy facilities, and disrupt regional grid balance. Therefore, an accurate assessment of extreme wind speeds at wind turbine hub height and their spatiotemporal variation under climate change is critical for the planning of wind energy and for guaranteeing regional energy security. In this study, the 100‐m extreme wind speeds in China are estimated using an empirical downscaling and Bayesian model averaging ensemble method with the latest ERA5 reanalysis and 20 global climate models (GCMs) from the Coupled Model Intercomparison Project phase 6 (CMIP6). Two shared socioeconomic pathways (SSP), that is, SSP2‐4.5 and SSP5‐8.5, are considered to account for the uncertainty in anthropogenic emissions. According to the results, the highest extreme wind speeds are primarily found in Inner Mongolia, northeast China, western Tibet, and the eastern coastal region. Extreme wind speeds in central and southeastern China are projected to increase by approximately 2% in the middle (2031–2060) and the end (2071–2100) of the 21st century relative to the baseline period (1985–2014). Summer extreme wind speeds in northwestern Tibet are expected to increase by more than 9% at the end of the century. The findings of this study indicate that it is important to take the present and projected changes in local wind extremes into account when choosing locations for wind power plants and wind energy installations.
Characteristics and Mechanism of Interhemispheric Coupling in Austral Winter Revealed by Long‐Term Reanalysis Data for the Whole Middle Atmosphere
Authors: Koshin Dai , Sato Kaoru
Published: January 2024

Global characteristics of dynamical fields for the interhemispheric coupling (IHC) initiated with a sudden stratospheric warming (SSW) in the southern hemisphere in the austral winter were examined using the global reanalysis for the whole neutral atmosphere from a data assimilation with satellite observations over 15 years of 2005–2019. Even in the austral winter, a strong cold equatorial stratosphere associated with the SSW, which is essential for the IHC, occurs about once every two years. The mechanism of the IHC in the austral winter is basically similar to that in the boreal winter. However, there are two significant differences in the IHC characteristics between the austral and boreal winters. One is that the SSW in the austral winter occurs mainly at midlatitudes, whereas the SSW in the boreal winter occurs mainly at high latitudes. As a result, a warm temperature anomaly simultaneously appears in the southern polar mesosphere in the austral winter, which is not observed for the boreal winter. The other is related to the seasonal variation of the quasi‐two‐day wave activity and induced forcing and gravity wave forcing in the summer mesosphere. For the IHC events occurring in July, when these wave activities and forcings are high, the response in the summer mesosphere is similar to that of the boreal winter. In contrast, for late August and September, when these wave forcings are weak, the response in the summer mesosphere is small. This result indicates that the IHC characteristics are largely influenced by the seasonal variation of these waves.
Contrasting Styles of Salt‐Tectonic Processes in the Ionian Zone (Greece and Albania): Integrating Surface Geology, Subsurface Data, and Experimental Models
Authors: Soto J. I. , Tranos M. D. , Bega Z. , Dooley T. P. , Hernández P. , Hudec M. R. , Konstantopoulos P. A. , Lula E. , Nikolaou K. , Pérez R. , Pita J. P. , Titos J. A. , Tzimeas C. , Herra Sánchez de Movellán A.
Published: January 2024

The Ionian Zone (IZ) is one of the key elements of the fold and thrust belt (FTB) of the Albanian and Hellenides orogen and contains large outcrops of Triassic evaporites. The IZ consists of various thrust sheets with a general westward vergence, stacking over the Apulian and Pre‐Apulian zones, and repeating a thick carbonate sequence of Upper Triassic to Eocene age. Thrusting becomes younger toward the west with a piggyback sequence, starting during the latest Oligocene Epoch in the Internal Ionian and ending in the Pliocene in the External Ionian. We have studied the IZ in southern Albania and northwestern Greece using field observations and borehole data and by fully interpreting a recently acquired 2D seismic data set. Our objectives are to establish the geometry and nature of the contacts associated with the major Triassic outcrops, to unravel precursor salt diapirs, and to assess their role during the Alpine contraction. Salt structures include gentle salt pillows, isolated salt plugs and diapirs, thrust welds, and salt walls. Combining these observations with experimental modeling results, we show how these structures control the geometry and kinematics of the Alpine thrusts or the location and kinematics of recent strike‐slip faults. Salt minibasins have also been identified, demonstrating salt mobility conditioned Mesozoic sedimentation in the Ionian Basin. The use of salt‐tectonics principles to evaluate the structural style and evolution of the IZ FTB also opens new directions for interpreting the subsurface structure and evolution of the region.
N-acetylcysteine during critical neurodevelopmental periods prevents behavioral and neurochemical deficits in the Poly I:C rat model of schizophrenia
Authors: Romero-Miguel Diego , Casquero-Veiga Marta , Lamanna-Rama Nicolás , Torres-Sánchez Sonia , MacDowell Karina S. , García-Partida José A. , Santa-Marta Cristina , Berrocoso Esther , Leza Juan C. , Desco Manuel , Soto-Montenegro María Luisa
Published: January 2024

Schizophrenia is a chronic neurodevelopmental disorder with an inflammatory/prooxidant component. N-acetylcysteine (NAC) has been evaluated in schizophrenia as an adjuvant to antipsychotics, but its role as a preventive strategy has not been sufficiently explored. We aimed to evaluate the potential of NAC administration in two-time windows before the onset of symptoms in a schizophrenia-like maternal immune stimulation (MIS) rat model. Pregnant Wistar rats were injected with Poly I:C or Saline on gestational day (GD) 15. Three different preventive approaches were evaluated: 1) NAC treatment during periadolescence in the offspring (from postnatal day [PND] 35 to 49); 2) NAC treatment during pregnancy after MIS challenge until delivery (GD15–21); and 3) NAC treatment throughout all pregnancy (GD1–21). At postnatal day (PND) 70, prepulse inhibition (PPI) and anxiety levels were evaluated. In vivo magnetic resonance (MR) imaging was acquired on PND100 to assess structural changes in gray and white matter, and brain metabolite concentrations. Additionally, inflammation and oxidative stress (IOS) markers were measured ex vivo in selected brain regions. MIS offspring showed behavioral, neuroanatomical, and biochemical alterations. Interestingly, NAC treatment during periadolescence prevented PPI deficits and partially counteracted some biochemical imbalances. Moreover, NAC treatments during pregnancy not only replicated the beneficial outcomes reported by the treatment in periadolescence, but also prevented some neuroanatomical deficits, including reductions in hippocampal and corpus callosum volumes. This study suggests that early reduction of inflammation and prooxidation could help prevent the onset of schizophrenia-like symptoms, supporting the importance of anti-IOS compounds in ameliorating this disorder.
Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients
Authors: Pozzi Marco , Vantaggiato Chiara , Brivio Francesca , Orso Genny , Bassi Maria Teresa
Published: January 2024

The metabolic effects induced by antipsychotics in vitro depend on their action on the trafficking and biosynthesis of sterols and lipids. Previous research showed that antipsychotics with different adverse effects in patients cause similar alterations in vitro, suggesting the low clinical usefulness of cellular studies. Moreover, the inhibition of peripheral AMPK was suggested as potential aetiopathogenic mechanisms of olanzapine, and different effects on autophagy were reported for several antipsychotics. We thus assessed, in clinically-relevant culture conditions, the aetiopathogenic mechanisms of olanzapine, risperidone and ziprasidone, antipsychotics with respectively high, medium, low metabolic risk in patients, finding relevant differences among them. We highlighted that: olanzapine impairs lysosomal function affecting autophagy and autophagosome clearance, and increasing intracellular lipids and sterols; ziprasidone activates AMPK increasing the autophagic flux and reducing intracellular lipids; risperidone increases lipid accumulation, while it does not affect lysosomal function. These in vitro differences align with their different impact on patients. We also provided evidence that metformin add-on improved autophagy in olanzapine-treated cells and reduced lipid accumulation induced by both risperidone and olanzapine in an AMPK-dependent way; metformin also increased the production of bile acids to eliminate cholesterol accumulations caused by olanzapine. These results have different clinical implications. We demonstrated that antipsychotics with different metabolic impacts on patients actually have different mechanisms of action, thus supporting the possibility of a personalised antipsychotic treatment. Moreover, we found that metformin can fully revert the phenotype caused by risperidone but not the one caused by olanzapine, that still activates SREBP2.
Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive
Authors: Mitchell Caitlin S. , Campbell Erin J. , Fisher Simon D. , Stanton Laura M. , Burton Nicholas J. , Pearl Amy J. , McNally Gavan P. , Bains Jaideep S. , Füzesi Tamás , Graham Brett A. , Manning Elizabeth E. , Dayas Christopher V.
Published: January 2024

Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like states in animals. Whilst there is a clear relationship between stress and motivational drive, the mechanisms underpinning this association remain unclear. One hypothesis is that the endocrine system, via corticotropin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus (PVN; PVNCRH), initiates a hormonal cascade resulting in glucocorticoid release, and that excessive glucocorticoids change brain circuit function to produce depression-related symptoms. Another mostly unexplored hypothesis is that the direct activity of PVNCRH neurons and their input to other stress- and reward-related brain regions drives these behaviors. To further understand the direct involvement of PVNCRH neurons in motivation, we used optogenetic stimulation to activate these neurons 1 h/day for 5 consecutive days and showed increased acute stress-related behaviors and long-lasting deficits in the motivational drive for sucrose. This was associated with increased Fos-protein expression in the lateral hypothalamus (LH). Direct stimulation of the PVNCRH inputs in the LH produced a similar pattern of effects on sucrose motivation. Together, these data suggest that PVNCRH neuronal activity may be directly responsible for changes in motivational drive and that these behavioral changes may, in part, be driven by PVNCRH synaptic projections to the LH.
The magnitude and variability of neurocognitive performance in first-episode psychosis: a systematic review and meta-analysis of longitudinal studies
Authors: Catalan Ana , McCutcheon Robert A. , Aymerich Claudia , Pedruzo Borja , Radua Joaquim , Rodríguez Victoria , Salazar de Pablo Gonzalo , Pacho Malein , Pérez Jose Luis , Solmi Marco , McGuire Philip , Giuliano Anthony J. , Stone William S. , Murray Robin M. , Gonzalez-Torres Miguel Angel , Fusar-Poli Paolo
Published: January 2024

Neurocognitive deficits are a core feature of psychotic disorders, but it is unclear whether they affect all individuals uniformly. The aim of this systematic review and meta-analysis was to synthesize the evidence on the magnitude, progression, and variability of neurocognitive functioning in individuals with first-episode psychosis (FEP). A multistep literature search was conducted in several databases up to November 1, 2022. Original studies reporting on neurocognitive functioning in FEP were included. The researchers extracted the data and clustered the neurocognitive tasks according to the seven Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) domains and six additional domains. Random-effect model meta-analyses, assessment of publication biases and study quality, and meta-regressions were conducted. The primary effect size reported was Hedges g of (1) neurocognitive functioning in individuals at FEP measuring differences with healthy control (HC) individuals or (2) evolution of neurocognitive impairment across study follow-up intervals. Of 30,384 studies screened, 54 were included, comprising 3,925 FEP individuals and 1,285 HC individuals. Variability analyses indicated greater variability in FEP compared to HC at baseline and follow-up. We found better neurocognitive performance in the HC group at baseline and follow-up but no differences in longitudinal neurocognitive changes between groups. Across the 13 domains, individuals with FEP showed improvement from baseline in all studied domains, except for visual memory. Metaregressions showed some differences in several of the studied domains. The findings suggest that individuals with FEP have marked cognitive impairment, but there is greater variability in cognitive functioning in patients than in HC. This suggests that subgroups of individuals suffer severe disease-related cognitive impairments, whereas others may be much less affected. While these impairments seem stable in the medium term, certain indicators may suggest potential further decline in the long term for a specific subgroup of individuals, although more research is needed to clarify this. Overall, this study highlights the need for tailored neurocognitive interventions for individuals with FEP based on their specific deficits and progression.