bluuebunny/crossref_metadata_2025 huggingface dataset:
A new parallel data geometry analysis algorithm to select training data for support vector machine
Authors: Shi Yunfeng , Lv Shu , Shi Kaibo
Published: January 2024

Support vector machine (SVM) is one of the most powerful technologies of
machine learning, which has been widely concerned because of its
remarkable performance. However, when dealing with the classification
problem of large-scale datasets, the high complexity of SVM model leads
to low efficiency or become impractical. Due to the sparsity of SVM in
the sample space, this paper presents a new parallel data geometry
analysis(PDGA) algorithm to reduce the training set of SVM, which helps
to improve the efficiency of SVM training. The PDGA introduce
mahalanobis distance to measure the distance from each sample to its
centroid, and based on this, define hyperellipsoid spatial density to
help remove dense redundant data. When further reducing the training
set, cosine angle distance analysis method is proposed to determine
whether the samples are redundant data, to ensure that the valuable data
are not removed. Different from the previous data geometry analysis
methods, the PDGA algorithm is implemented in parallel, which leading to
substantial saving in the computational cost. Experimental results on
artificial dataset and 6 real datasets show that the algorithm can adapt
to different sample distributions, significantly reduce the training
time and memory requirements without sacrificing the classification
accuracy, and its performance is significantly better than the other 4
competitive algorithms.
Effective analysis of platelet transfusion dose in hematological pediatric patients with thrombocytopenia：A single center retrospective cohort study
Authors: Liu Qin , Chen Xin , Duan Ling , Chen Ping , Gan Shan , Xie Songli , Chen Hanwei , Li Jingxing , Hu Hongbing
Published: January 2024

Background: Platelet transfusion is a common method to prevent
hemorrhage in hematological pediatric patients. There is a shortage of
platelet resources in many district of China. Small-dose platelet
transfusion may be an effective measure to solve these problems.
Methods: A retrospective analysis of platelet transfusion in 96
hematological pediatric patients with thrombocytopenia. According to the
actual platelet dosage transfused, we divided the cases into two groups:
low-dose platelet transfusion group (<3.0×10^11
platelet/m2, LDC, n=109) and high-dose platelet transfusion group
(≥3.0×10^11 platelet/m2, HDC, n=90). To evaluate the effect of
platelet transfusion, we assessed the post-transfusion platelet
increment (PPI) values, changes of hemoglobin after platelet transfusion
and calculated the corrected count increment (CCI) at 24h after
transfusion between the two groups. We also recorded adverse reactions
during transfusion. Results: Through statistical analysis, we found that
there was no statistical difference in the 24h CCI value, hemoglobin
change value and the effective rate of platelet transfusion between LDC
and HDC groups. There was no adverse reaction in the LDC group, but 1
adverse reaction case in the HDC group. Conclusion: Low dose platelet
transfusion is effective in pediatric patients with thrombocytopenia.
Association between adequacy of prenatal care and severe maternal morbidity among teenage pregnancies in South Korea: a nationwide population-based retrospective cohort study
Authors: Nam Jin Young , Oh Sarah , Park Eun-Cheol
Published: January 2024

Objective: To study the association between the risk of severe maternal
morbidity and adequacy of prenatal care in teenage pregnancies. Design:
Population-based retrospective cohort study. Setting: National Health
Insurance Service National Delivery Cohort in Korea Population: A total
of 23,202 delivery cases including pregnant teenagers aged 13 to 19
years and gestational age ≥ 37 weeks between 2003 and 2018. Methods: We
used a generalized estimating equation model with adjustment for all
covariates to determine the adjusted relative risk (RR) associated with
severe maternal morbidity. Main Outcome Measures: severe maternal
morbidity, Kessner Adequacy of Prenatal Care Index Results: Severe
maternal morbidity occurred in 723 (3.1%) of the 23,202 delivery cases
investigated, over a 16-year period. The risk of severe maternal
morbidity was 1.8-fold higher in teenagers with inadequate prenatal care
(RR 1.81, 95% confidence interval [CI] 1.39– 2.37) and 1.6-fold
higher in those with intermediate prenatal care (RR 1.59, 95% CI
1.33–1.87) than in those with adequate prenatal care. Synergistic
effects of inadequate prenatal care and maternal comorbidity were
observed on severe maternal morbidity. Conclusion: This study confirmed
that inadequate prenatal care was associated with the risk of severe
maternal morbidity among pregnant teenagers. Notably, maternal
comorbidity and inadequate prenatal care produced synergistic effects on
severe maternal morbidity. Therefore, public health policy makers should
focus on the development and implementation of programs to ensure
adequate prenatal care and support financial accessibility of healthcare
to improve teenage mothers’ health.
Is minimally invasive mitral valve surgery inappropriate for redo-surgery or elderly patients? -- Study of 55 consecutive cases following minimally invasive mitral valve replacement via right mini-thoracotomy
Authors: Nakayama Taisuke , Nakamura Yoshitsugu , Yasumoto Yuto , Yoshiyama Daiki , Kuroda Miho , Nishijima Shuhei , Tsuruta Ryo , Narita Takuya , Ito Yujiro
Published: January 2024

Background: Minimally invasive mitral valve surgery has been established
as a routine procedure at our institution. In the present study, early
and mid-term outcomes of patients who underwent minimally invasive
mitral valve replacement (MIMVR), including redo-operations and elderly
patients, during the 5-year post-surgery period were analyzed to review
short-term morbidity and mortality, and mid-term results. Methods:
Preoperative variables, intraoperative findings, and postoperative
outcomes of MIMVR patients treated from January 2014 to November 2020
and prospectively stored in a database were reviewed. Survival and
freedom from cerebrovascular events were evaluated using life tables and
Kaplan-Meier analysis. Results: A total of 445 patients underwent
minimally invasive mitral valve surgery during the study period, of whom
55 received mitral valve replacement (MVR), including 18 cases of
redo-MVR and 10 elderly (≥80 years old) patients. Mean age at the time
of surgery was 70.7±11.3 years. The number of patients who underwent
conversion to a sternotomy was 0, while 30-day mortality was noted in
one (2%). For all MIMVR cases, 1- and 5-year survival was 90.8±3.9 %
and 76.5±7.1%, respectively. Furthermore, freedom from cerebrovascular
events and anticoagulation-related complications was 94.3±3.2% and
84.2±6.3% at 1 and 5 years, respectively. In univariate analysis,
independent predictors of hospital mortality and prolonged hospital stay
included infectious endocarditis, while previous cardiac surgery and
elderly status were not significant factors. Conclusions: MIMVR can be
performed safely and effectively for redo-MVR and in elderly patients
with very few perioperative complications. Early and mid-term outcomes
in the present cohort were acceptable.
Storming the castle: A case report of multi-system dysregulation in a child with Castleman disease
Authors: DeMarsh Samantha , Kendall Nicole , Bacha Christine , Ardoin Stacy , Rose Melissa
Published: January 2024

Castleman Disease is a rare non-clonal lymphoproliferative disorder that
predisposes towards adults with very few reported cases in children.
Presented is a 12-year-old male with progressive abdominal pain,
vomiting, and fever. Laboratory testing showed elevated inflammatory
markers, hemolysis, kidney injury, coagulopathy, thrombocytopenia, and
refractory hypocalcemia. Imaging demonstrated an adrenal mass,
hepatosplenomegaly, generalized lymphadenopathy, and increased bone
marrow uptake without focality. The diagnosis of Castleman Disease was
made with tissue biopsy and marked disease regression occurred after
high dose steroids and interleukin-6 inhibition. Awareness of Castleman
disease in a pediatric patient is essential to providing adequate and
timely care.
Evaluation of extracellular electron transfer in Pseudomonas aeruginosa by a novel co-expression of nicotinate mononucleotide adenyltransferase and quinolate phosphoribosyltransferase genes
Authors: Ajunwa Obinna , Odeniyi Olubusola , Garuba Emmanuel , Nair Mrinalini , Marsili Enrico , Onilude Abiodun
Published: January 2024

Pseudomonas aeruginosa (PA) is an electrogenic bacterium, in which
extracellular electron transfer (EET) is mediated by
microbially-produced phenazines, especially pyocyanin. Increasing EET
rate in electrogenic bacteria is key for the development of biosensors
and bioelectrofermentation processes. In this work, the production of
pyocyanin and Nicotinamide Adenine Dinucleotide (NAD) synthetase in the
electrogenic strain PA-A4 is determined in microbial fuel cells (MFCs).
The MFC potentials correlates with the NAD synthetase activity and with
pyocyanin production. With the fusion and combined overexpression of
nicotinic acid mononucleotide adenyltransferase (nadD) and quinolic acid
phosphoribosyltransferase (nadC) genes, which are distant on the PA
genomic map, faster co-transcription and increased NAD synthetase
activity is enabled. The resulting PA-A4 nadD+nadC shows both increased
pyocyanin concentration and MFC potential than the unmodified strain.
Extracellular respiratory mechanisms in PA are linked with NAD
metabolism, and targeted increased yield of NAD could directly lead to
enhanced EET. However, this is the first report of electrogenicity
enhancement in PA by fusion and combined overexpression of nadD and nadC
genes.
The bounce-off effect on the initial collection efficiency of Brownian aerosols in fibrous filtration.
Authors: Chang You-Im , Liao Keng-Yi , Jang Larry
Published: January 2024

By using the Brownian dynamics simulation method, the bounce-off effect
of aerosol particles on their initial collection efficiencies in fibrous
filtration is investigated in the present work. Based on the simulation
results and available aerosol filtration experimental data, two new
correlations for predicting the initial collection efficiency are
derived. It is found that the correlations developed in this work
provide accurate agreement with available experimental results.
Association between neutrophilic granulocyte percentage and diabetes mellitus in Cushing’s syndrome patients: a cross-sectional study
Authors: WANG BAOMIN , Yang Yumei , Yuan Haoyue , Li Xiaomu
Published: January 2024

Background: Glucose metabolism is frequently impaired in patients with
Cushing’s syndrome (CS), which is caused by chronic exposure to
glucocorticoid excess. Inflammation plays a central role in the
pathophysiology of diabetes mellitus (DM). The present study aimed to
investigate the potential associations of inflammatory blood cell
parameters, including white blood cell (WBC) count, neutrophils count,
neutrophilic granulocyte percentage (NEUT%), lymphocyte count (LYM),
lymphocyte proportion (LYM%) with diabetes mellitus in Cushing’s
syndrome patients. Materials and Methods: This cross-sectional study was
performed in Zhongshan Hospital, Fudan University, China. A total 150
patients with Cushing’s syndrome were retrospectively screened from
2017-2019. The demographic, clinical data, and blood samples were
documented (lipids, adrenal, glucose, inflammatory blood cell
parameters). Statistical analyses were carried out by using SPSS
software package version 13.0. Results: The prevalence of diabetes
mellitus was 38.7% in Cushing’s syndrome. Patient with DM had higher
WBC, neutrophils, NEUT% levels than patients without DM (P <
0.05). As the NEUT% increased, there was a step-wise increase in
glucose and HbA1c level. Additionally, in the multivariate logistic
regression, NEUT% was an independent risk factor for the development of
DM, regardless of gender, age, BMI, triglyceride and 12MN cortisol level
(OR=2.542, 95%CI 1.337-4.835, P<0.001). Conclusions: In
conclusion, elevated NEUT% level was associated with diabetes in
patients with Cushing syndrome. The neutrophils granulocyte percentage
may be used as a new predictor for diabetes in Cushing’s syndrome
patients.
Distribution of arrhythmic events in COVID-19 patients receiving favipiravir and hydroxychloroquine
Authors: Karadavut Serhat , Altintop Ismail
Published: January 2024

Background: Favipiravir, first used for novel influenza strains, is
being used today in coronavirus disease 2019 (COVID-19). While many
studies have been reported in the literature on hydroxychloroquine’s
(HQ) arrhythmogenic adverse effects, data on favipiravir are limited.
The authors purposed to demonstrate that the arrhythmic effects of
favipiravir are not negligible. Methods: The researchers conducted a
retrospective observational study on 194 COVID-19 patients. The study
population was classified into two groups based on the treatment
regimen: favipiravir (n=101) and HQ (n=93). Pre/post-medication
electrocardiograms were evaluated for arrhythmic events. Results: Twenty
of 101 (19.8%) subjects in the favipiravir group and 13 of 93 (13.9%)
subjects in the HQ group had arrhythmogenic events (p=0.42). The most
frequent arrhythmic events in the favipiravir group were sinus
bradycardia (13 of 20, 65%) and third-degree atrioventricular block (4
of 20, 20%). Corrected QT (QTc) prolongation was the most seen
arrhythmogenic adverse effect (9 of 13, 69%) in the HQ group. The
proportion of patients with prolonged QTc were higher in the HQ group
than the favipiravir group (9 vs. 3, p=0.04). However, the difference
between final and baseline QTc did not differ between the HQ and the
favipiravir group (11 [IQR:-9—57] vs. 12 [IQR:-7—103],
p=0.59, respectively). The change between pre and post-treatment heart
rate was more remarkable in the favipiravir group than the HQ group (12
[IQR:-6—70] vs. 5 [IQR:-8—41], p<0.001,
respectively). Conclusions: Favipiravir was significantly associated
with sinus bradycardia requiring drug withdrawal. Clinicians should more
routinely implement arrhythmia monitoring for patients receiving
favipiravir.
Extraprostatic Extension In Multiparametric MRI; Is Presurgical Detection Possible?
Authors: Ayaz Muzaffer , Gülseren Yıldız , Inan Ibrahim , Kabaalioglu Adnan , Yıldırım Asıf
Published: January 2024

ABSTRACT PURPOSE: The aim of this study was to evaluate the efficacy of
1.5T MRI using lesion length (LL) and tumor-capsule contact length (TCL)
in detecting extraprostatic extension (EPE) in prostate cancer (PCa).
MATERIALS and METHODS: A total of 110 patients who underwent radical
prostatectomy due to PCa were enrolled. Preoperative MR images of the
patients were evaluated retrospectively by two independent observerswho
did not know the histopathological results. The observers evaluated LL
and TCL. The radiological findings, including lesion location, were
verified using histopathological mapping. RESULTS: Multiparametric MR
examination of the prostate demonstrated low sensitivity but high
specificity, with significant differencesfor detecting EPE (Observer 1,
p < 0.0001; Observer 2, p = 0.003). The increased PI-RADS
score correlated positively with the increased EPE rate. The LL and TCL
demonstrateda statistically significant difference between patients with
and without EPE. The TCL was a significant parameter for EPE, with high
sensitivity and low specificity for both observers. Cut-off values were
obtained for both the LL and TCL. CONCLUSION: The results revealed that
1.5T MRI demonstrated low sensitivity and high specificity in detecting
EPE. The LL and TCL may be beneficial indirectly in detecting EPE.
Keywords: Prostate Cancer; Capsular Invasion; Extraprostatic Extension;
Multiparametric Prostate MR; Tumor-Capsule Contact Length
Analysis and prediction of supermarket energy consumption time series with significant fractional order characteristics
Authors: Wang Jing , Liu Yi , Wu Haiyan , Chen YangQuan , Viola Jairo
Published: January 2024

The actual industrial processes are always accompanies by many
non-Gaussian behaviors due to the systems complexity. These behaviors
are fractional order characteristics, which are very difficult to
analyze by traditional analysis methods. This paper presents a detail
fractional order theory analyses based on the fractional order
characteristics present in industrial process. Initially, the -stable
distribution is employed to fit the probability density distribution of
the data and the auto correlation function is applied to find the long
range dependence characteristic hidden in the process. Next, a re-scaled
range method and multifractal detrended fluctuation analysis method is
applied to analyze the fractional order features of the process in
detail. Then, a fractional auto-regressive integrated moving average
model (FARIMA) is proposed to predict accurately of the time series
based on the fractional order characteristic of the system. Experimental
results show that the superiority for prediction model with fractional
order thinking.
Stereotactic body radiation therapy for refractory premature ventricular contractions that originate from the left ventricular summit: a case report
Authors: Huang Li-hong , Gao Zhi-Zhang , Li Wei-Yong , Zhang Hou-Cai , Zheng Jian-Wei , Liu Xing-Peng
Published: January 2024

The case highlights an available method to minimize the target volume
and reduce the radiation dose by using a temporary catheter, to reduce
the long-term risk of radiotherapy for ventricular arrhythmias.
Mitochondrial phylogenomics and historical biogeography of family Tephritidae (Diptera)
Authors: Zhang Yue , Li Hu , Feng Shiqian , Qin Yujia , Meyer Marc De , Virgilio Massimiliano , Singh Sandeep , Jiang Fan , Priscilla Kawi Anastasia , Susanto Agus , Martinez-Sañudo Isabel , Wu Jiajiao , BADJI Kemo , Fekrat Lida , Davaasambuu Undarmaa , Li ZHIHONG
Published: January 2024

The Tephritidae is one of the largest families of Diptera with high
diversity and globally wide distribution, including a range of important
agricultural pests. However, the origin, phylogeny and evolution history
of Tephritidae remain poorly understood. We undertook the first
comprehensive mitogenomic study covering phylogenetic reconstruction,
divergence time estimation and historical biogeography analyses by
analyzing 147 mitochondrial genomes representing three subfamilies,
seven tribes, 11 genera and 82 species. The results recovered all the
three subfamilies, seven tribes and 11 genera as monophyletic group.
Within Dacini subfamily, our phylogeny strongly supported the sister
group relationship of (Zeugodacus + Dacus) + Bactrocera, which further
supported to raise Zeugodacus as generic level of Dacini. On the other
hand, our molecular phylogenetic analyses did not align well with the
currently recognized subgeneric designations within Ceratitis, Dacus and
Zeugodacus. Some subgenera were recovered as polyphyletic or
paraphyletic, implying the incongruence between morphological characters
and mitogenomic data. Neither the taxa within the Ceratitis FARQ complex
nor those within the Bactrocera dorsalis complex could be clearly
distinguished as distinct species corresponding to the morphospecies by
mitochondrial phylogenetic tree. Divergence time estimation and
historical biogeography analyses indicated that the earliest common
ancestor of the Tephritidae, originated in the Palearctic realm at
138.92-71.44 Ma, with the subsequent divergence into Dacinae +
Trypetinae and Tephritinae at 115.19-67.45 Ma equally in the Palearctic
realm. Dacini might have originated in Laurasia rather than Gondwana and
diverged into Bactrocera and Dacus + Zeugodacus at 48.43-28.70 Ma after
India plate docked with Laurasia.
Office blood pressure versus ambulatory blood pressure monitoring in Spanish children with and without obesity
Authors: Santaliestra-Pasíasa Alba M , Herráiz-Gastesi Gonzalo , Pérez-Gimeno Gloria , Villagrasa Pilar Samper , Moreno Luis A , Leis Rosaura , Aguilera Concepción , Ruperez Azahara , Bueno-Lozano Gloria
Published: January 2024

Background: Paediatric primary hypertension is partly attributable to
the childhood obesity epidemic. 24-hour ambulatory blood pressure
monitoring could better identify blood pressure alterations in this
group. The aim of the present study is to estimate the proportion of
blood pressure abnormalities in obese children and the prevalence of the
different blood pressure categories according to the American Heart
Association. Procedure: A case-control study was designed (n=154,
53.2%boys) including 77 obese and 77 normal-weight children aged 7-15
years. International Obesity Task Force reference values were used to
define obesity and normal weight. Office blood pressure and ambulatory
blood pressure for 24h were assessed and children were classified
according to the American Heart Association categories. Results: Means
of systolic and diastolic blood pressure were higher in obese
participants. Office’s systolic hypertension was present in 19.5% of
obese vs 5.2% of normal-weight and night-time systolic hypertension
affected 11.7% of obese vs 2.6% of normal-weight (p <0.05).
Non-dipping was present in 54.5% of obese vs 35.1% of normal-weight in
the systolic register (p=0.015). Prevalence of abnormal blood pressure
loads was higher in obese. Exclusively in the night-time, ambulatory
hypertension was diagnosed in obese children (3.9%). A high proportion
of obese were uncategorized. Conclusions: A high proportion of blood
pressure abnormalities has been observed taking into consideration the
entire 24h, daytime and night-time periods. Only with the office BP
reading, the primary hypertension seems to be over-diagnosed. There is
still an urgent need for more comprehensive studies linking ambulatory
blood pressure patterns to cardiovascular event
Prenatal counseling for extreme prematurity at the limit of viability: a scoping review
Authors: Proost L De , Geurtzen Rosa , M'hamdi Hafez Ismaili , Reiss Irwin , Steegers Eric , Verweij E.J.T. (Joanne)
Published: January 2024

This scoping review identifies characteristics of prenatal counseling
for extreme prematurity at the limit of viability. Embase, Medline, Web
of Science, Cochrane, CINAHL, and Google Scholar were searched. 47
articles were included. Almost half of them were published between 2018
and 2021. The following characteristics could be identified:
personalization, parent-physician relationships, shared decision-making,
bias, emotions and anxiety, psychosocial factors, parental values,
religion, spirituality and hope, quality of life, and uncertainty. A
trend in time towards personalization was also remarkable. However, more
research is needed on parental perspectives on personalizing prenatal
counseling.
The effect of atropine used in dobutamine stress echocardiography on pupil diameter
Authors: Soulis Dimitrios , Papaioannou Theodore , Zozolou Maria , Daskalopoulou Stella , Vlachopoulos Charalampos , Bethanis Dimitrios , Triantafyllou Dimitrios
Published: January 2024

Aims The aim of this study is to investigate whether atropine when
administered in persons without glaucoma during dobutamine stress
echocardiography causes pupillary dilation. Methods and Results 144
patients referred for dobutamine stress echocardiography (DSE) study
without any history of glaucoma were observed. 39 were excluded from the
study because they did not receive atropine. Pupil diameter was measured
at the same light conditions before and after each study session. 105
patients received during DSE atropine doses from 0.1 mg to 1.25mg (most
patients received 0.25-0.75mg). For the total of 210 examined eyes pupil
diameter remained statistically unaltered after each DSE test
(3.65±0.799 mm before vs 3.63±0.766 mm after, p=0.737 respectively).
Similarly, pupil diameter remained unchanged when left and right eyes
were separately compared (Right Eye: 3.770 ± 0.812 before vs 3.752 ±
0.745 mm after, p=0.821 and Left eye: 3.521±0.770 before vs 3.499 ±
0.770 mm after, p=0.806, respectively). Diameter of right and left pupil
remained unaltered also after grouping patients by gender and iris
pigmentation. Age, weight, atropine dose and propranolol dose are not
correlated with changes in pupil diameter. Conclusion Intravenous
atropine, in usual doses administered in dobutamine stress
echocardiography, does not cause mydriasis in adults without glaucoma.
This is an indication that – though it is not currently recommended–
atropine use during DSE in patients with narrow angle glaucoma may be
potentially safe; further studies are needed to investigate this option.
Complete genome and pathogenesis of a novel recombinant Senecavirus A isolate in China
Authors: Li Chen , Wu Xiaoyan , Wang Xiaoli , Shi Jianli , Liu Chang , Peng Zhe , Han Hong , Xu ShaoJian , Wang Shuo , Ma Yingru , Zheng Limei , Li Jun , Wang Zhao
Published: January 2024

The Senecavirus A (SVA), formerly called Seneca Valley virus (SVV) which
was first isolated in the United States (US) in 2002. In this study, a
SVA strain was isolated from a pig herd in Shandong Province in China
and designated as SVA-CH-SDGT-2017. The full-length genome, excluding
the poly (A) tail of the SVA isolates, was 7280 nucleotides long, with
the genomic organization resembling and shares high nucleotide
identities of 90.7% to 96.9% with other previously reported SVA
isolates. To investigate the pathogenicity of the SVA isolate,
experimental infections of pigs were performed. The SVA strains
successfully infected the pigs, evidenced by presence of virus shedding
and robust serum neutralizing antibody responses. Moreover, the
contact-exposed pigs showed 100-fold reduction compared to that of
inoculated group. Our findings provide useful data for studying the
pathogenesis and transmission of SVA in pigs.
IMPACT OF PANDEMIC ON COVID-19 QUALITY OF LIFE AND EFFECTING FACTORS AMONG ADULTS WITH LONG COVID: FAMILY HEALTH CENTERS BASED STUDY
Authors: YILMAZEL GÜLAY , KELEŞ EMRE
Published: January 2024

Aim: The aim of the study was to evaluate impact of pandemic on COVD-19
quality of life and effecting factors among adults wıth long COVID.
Methods: The study included 440 individuals applying at family health
centers for any reason. Participants were asked to complete a survey
after their written consent was received. The survey consisted of two
parts: the first related to socio-demographic information; the second
including “COVID-19 Quality of Life Scale” and the “Perception Health
Scale” . Mean, median, Kruskal Wallis and Mann-Whitney U tests and
Sperman Correlation analysis were used in analysis. Results: Of the
participants, 40.9% were male, 59.1% were female as well as 33.2% had
at least one long COVID symptoms, 44.5% were reported that symptoms
continued for 1-3 months. In addition, the median age was 41 years, the
body mass index was 24.6 kg/m2. The median time since first infected was
7 month. The median COV19-QoL and Perception of Health Scale scores were
3.0 and 40.0 respectively. Among the prolonged COVID symptoms,
fatigue/tiredness was shown with 53.2%. Other common symptoms were
muscle pain (27.1%), headache/dizziness (24.1%), difficulty thinking
or concentrating (20.9%), difficulty in breathing and heart palpitation
(20.0%). The COV19-QoL median score significantly differed by education
level, existing chronic conditions, COVID-19 treatment type, number of
experienced long COVID symptoms and continuation of the symptoms
p<0.05. There was significant correlation between COV19-QoL
and age, time since first infected and perceived health score
(p<0.05) . Conclusion: Aging, low education, existing chronic
conditions, hospitalization, number of long symptoms, continuation of
symptoms, and perception of health were risky factors for impact of the
pandemic on COVID-19 quality of life. Specific rehabilitation services
and programmes seems to be urgent need in overcoming this issue and to
improve health. Key words: Long COVID, COVID-19, quality of life,
adults, family health
The prognostic significance of preoperative CA-125 levels in uterine papillary serous carcinomas
Authors: cakir ilker , Karataşlı Volkan , Gülseren Varol , Ayaz Duygu , Can Behzat , Çakır Zübeyde Emiralioğlu , gorgulu goksen , kuru oguzhan , Sancı Muzaffer , gokcu mehmet
Published: January 2024

Aim: This study aimed to determine the relationship between preoperative
cancer antigen(CA) 125 levels and clinicopathologic prognostic factors
as well as appropriate cut-off levels for pure uterine papillary serous
carcinoma (UPSC). Methods: Study data were collected from the documents
and electronic medical records of patients who were diagnosed with pure
UPSC between 2005 and 2020 in our institution. The association between
clinicopathological variables and CA-125 were analyzed. The accuracy of
the preoperative serum CA125 value in predicting metastasis sites was
evaluated by the receiving operating characteristic (ROC) curve analysis
and the most appropriate cut-off values available were selected.
Results: Seventy-eight patients met the study criteria. Median value of
preoperative serum CA-125 level was higher in patients with omental(p
<0.001), ovarian(p <0.001), cervical involvement (p
= 0.017) and deep myometrial invasion(≥50%) (p = 0.001). According to
the ROC curve, the optimal cut-off value of preoperative CA125 level for
predicting omental involvement was 35.5 U/mL (sensitivity: 93.8%,
specificity: 79.3%), cervical involvement was 15.0 U/mL (sensivity:
86.8%, specificity: 44.7%) and ovarian involvement was 32.5 U/mL
(sensivity: 77.3%, specificity: 72.2%). Conclusion: An elevated level
of preoperative serum CA-125 is a marker for omental, ovarian, cervical
involvement and deep myometrial invasion. There is a need for future
studies to evaluate the role of CA-125 in predicting recurrence and
survival in UPSC. Key Words: Cervical involvement, Cutoff value,
Preoperative CA-125, Uterine papillary serous carcinoma
“Chiari II malformation with Trisomy 18 – A rare bird
Authors: Yaqoob Sadia , Saleem Amna , Jaiswal Vikash , Ruxmohan Samir , Zakhary Christine
Published: January 2024

Studies have revealed an association of neural disfigurement with
trisomy 18. Hereby, we report a rare coalition of Trisomy 18 and Arnold
Chiari malformation along with myelomeningocele in a premature neonate.
Despite managing hydrocephalus, the patient’ condition deteriorated over
time due to underlying cardiothoracic defects.
Social behaviors shift properties that are beneficial to plants in two-member consortia of Bacillus velezensis
Authors: Shao Jiahui , Liu Yan , Ding Hongyu , Xu Wenjuan , Zhao Xinye , Xie Jiyu , Fan Ben , Zhang Ruifu , Xu Zhihui , Shen Qirong
Published: January 2024

Bacillus spp. strains that are beneficial to plants are widely used in
commercial biofertilizers and biocontrol agents for sustainable
agriculture. Generally, functional Bacillus strains are applied as
single strain communities since the principles of synthetic microbial
consortia constructed with Bacillus strains remain largely unclear.
Here, we demonstrated that the kin discrimination system directly
affects the survival and function of two-member consortia composed of B.
velezensis SQR9 and FZB42 in the rhizosphere. A mutation in the global
regulator Spo0A of SQR9 markedly reduced the boundary phenotype with
wild-type FZB42, and the combined use of the spo0A mutant and FZB42
improved biofilm formation, root colonization and the production of
secondary metabolites that are beneficial to plants. We further
confirmed the correlation between the swarm discrimination phenotype
within community members and effects that are beneficial to plants in
greenhouse experiments. Our results provide evidence that social
interactions among bacteria could be an influencing factor in achieving
a desired community-level function.
Sharing wildlife conservation through 4 billion views on YouTube
Authors: Vins Mark , Aldecoa Mario , Hines Hunter N
Published: January 2024

YouTube is an online video sharing platform attracting billions of users
from global audiences. Videos containing wildlife are a popular subject,
with such content being a valuable tool for educating on wildlife
initiatives and having the potential to make a meaningful impact on
future conservation. Here we examine the YouTube channel
BraveWilderness. This channel has uploaded 662 videos and recently
surpassed 4 billion views for their wildlife-centric and
conservation-themed content. BraveWilderness shows diverse biodiversity
from a multitude of habitats, and often highlights under-represented
taxa. Successful videos, such as those that go viral, can be examined to
understand what images and messages resonate with a wide audience,
thereby informing conservation practitioners on future outreach efforts.
As internet use continues to expand, and the need for content increases,
scientists can benefit from participating with and directly contributing
to entertaining and educational digital media efforts beyond traditional
means of scientific communication.
Serum ischemia-modified albumin as an oxidative stress biomarker in lung tuberculosis patient
Authors: Demir Elif , Giden Zeliha Demir
Published: January 2024

Aim of Study: The goal of this study was to evaluate ischemia-modified
albumin (IMA) as a novel marker of oxidative stress in tuberculosis
patients and to investigate changes occurring in patients. Methods: Our
study included 50 patients with active lung tuberculosis and 48 healthy
controls. Serum ischemia-modified albumin was measured with automated
spectrometric method and results were compared statistically. Results:
We found that IMA levels were significantly higher in pulmonary
tuberculosis patients than in the control group. Albumin levels were
significantly lower in the patient group than in the control group.
Conclusion: The results of our study showed that we can use this
parameter as a new oxidative stress marker in the pathogenesis of
pulmonary tuberculosis. Evaluation of IMA and albumin parameters in
patients with pulmonary tuberculosis may contribute significantly to the
evaluation of these patients.
Mixed monotone iterative technique for fractional evolution equations IS-asymptotically periodic problem with non-instantaneous impulses
Authors: Li Qiang , Yuan Tianjiao , Wu Xu
Published: January 2024

In this paper, we discuss the existence of $IS$-asymptotically
$\omega$-periodic mild L-quasi-solutions for a class of
fractional evolution equations with non-instantaneous impulses. Under a
new concept of upper and lower solutions, a new monotone iterative
technique is constructed, and the necessary conditions for the existence
of extremal coupled mild $L$-quasi-solutions are obtained. Finally, an
example is given to illustrate the effectiveness of our theoretical
results.
Experience on Treating Variations of Facial Nerve in Cochlear Implant with Endoscopic Assistant of Access to the Round Window
Authors: Li Yifan , Tong Busheng , Qiu Jianxin
Published: January 2024

Objectives: Cochlear implant is the only solution of profound
sensorineural hearing loss. The round window implant provides minimal
injury to the inner ear, and may preserve the residual hearing, and the
key to insert the electrode array is to expose the round window, but
displaced facial nerve may hinder the visualization of the round window.
The aim of the study was to expose the round window and preserve the
full function of facial nerve with endoscopic assistant. Design: Cases
with variant facial nerve were observed with rigid endoscopy. The
locations of round window were assessed by endoscopy and we performed
retrofacial approach, or using “suspended” facial nerve technology to
expose the round window by shifting the facial nerve posteriorly.
Paticipants: Three cases were collected with variant facial nerve, two
cases performed retrofacial approach, one case performed “suspended”
facial nerve technology. Results: All cases inserted electrode array in
round window and preserve the residual hearing, and none of the cases
suffered facial nerve injury, chorda tympani nerve injury, misplacement
of the electrode array, and other complications. Conclusion: Rigid
endoscopy can provide a clear vision of round window, and assistant the
electric array insertion during cochlear implant surgery.
Peri-mitral Atrial Flutter Changed into Single Loop Biatrial Flutter during Ablation
Authors: Su Jialin , Wannenburg Thomas
Published: January 2024

Background: Anterior line ablation for peri-mitral atrial flutter (AFL)
is associated with biatrial flutter due to disruption of the electrical
conduction in the left atrial septum. Tachycardia cycle length (TCL)
prolongation during anterior line ablation of peri-mitral AFL can be due
to change of the AFL into a single loop biatrial flutter. Method: An AFL
case with valvular disease, cardiac surgery and prior ablation was
confirmed to be counterclockwise peri-mitral flutter with isthmus
identified on the left atrial septum by LAT, bipolar voltage and
propagation mapping. Ablation on the anterior and septum left atrium
(LA) targeting the isthmus prolonged TCL from 266 ms to 286 ms. A second
map was performed for both the left atrium (LA) and the right atrium
(RA). Result: The activation in LA remained to be counterclockwise, but
there was interruption of the LAT. The reentrant circuit was
counterclockwise single loop biatrial, involving the whole LA and the RA
septum with Bachmann bundle and the inferior posterior septum being the
connection between RA and LA. The AFL was terminated by alation at the
RA superior septum below SVC. Conclusion: Counterclockwise peri-mitral
flutter can change into single loop biatrial flutter during anterior
line ablation. RA mapping should be considered if there is prolonging of
TCL without termination of the AFL and if there is interruption of LAT.
The biatrial flutter can be terminated by ablation at the Bachmann
bundle insertion in the RA.
Effects of the 52% low-sodium salt applied to CM-DASH diet in hypertensive patients with type 2 diabetes：A Randomized Controlled Trial
Authors: Mu Lisha , Rao Huakun , Yu Pingping , Xu Huini , Wang Hao , Chen Dan , Tang Jie , Gong Tao , Li Jing , Mei Ying , Mu Lihong
Published: January 2024

Background and Aims: The DASH diet have been proven to be effective in
lowering blood pressure (BP), but it is rarely used in people with type
2 diabetes (T2D), especially in the Chinese population. We aimed to
evaluate the effects of 52% low- sodium salt applied to CM-DASH diet in
patients with hypertension and T2D. Methods and Results: This trial is a
single-blind, randomized controlled study conducted from December 2019
to November 2020 at Chongqing, China. 61 participants were randomly
allocated to intervention group or control group for 8 weeks.2
participants were lost, and 59 patients were finally included in the
analysis. The systolic blood pressure (SBP) and diastolic blood pressure
(DBP) of intervention group and control group were significantly
decreased compared with baseline, but there was no difference between
groups. The 24-hour urine Na+ and Cl- of the two groups decreased
significantly after intervention, but the increase of 24-hour urine K+
and the decrease of Na+/ K+ ratio were only observed in the intervention
group. Furthermore,the urine urinary albumin creatinine ratio (UACR) and
serum creatinine of two groups also decreased from baseline.
Conclusions: Following the CM-DASH diet in hypertensive patients with
T2D has beneficial effects in improving SBP and DBP. and the application
of 52% low-sodium salt has a significant effect in reducing sodium
intake and increasing potassium intake.
Pharmacokinetic Developability And Disposition Profiles Of Bispecific Antibodies
Authors: Datta-Mannan Amita , Brown Robin , Key Stephanie , Cain Paul , Feng Yiqing
Published: January 2024

Therapeutic strategies utilizing multi-functional and bispecific
antibodies (BsAb) that engage multiple pathways are a promising way to
improve and prolong efﬁcacy of biologics in complex disease indications.
In the early stages of discovery, BsAbs often exhibit a broad range of
pharmacokinetic (PK) behavior. Optimization of the neonatal Fc receptor
(FcRn) interactions and removal of undesirable physiochemical properties
have been used to improve the ‘pharmacokinetic developability’ for
various monoclonal antibody (mAb) therapeutics, yet there is a sparsity
of such information for BsAbs. The present work evaluated the influence
of FcRn interactions and inherent physiochemical properties on the
pharmacokinetics of two related single chain variable fragment (scFv)
based BsAbs. Despite their close relation, the two BsAbs exhibited
disparate PK in cynomolgus monkeys with BsAb-1 having aberrant clearance
of ~2 mL/hr/kg and BsAb-2 displaying a typical PK with a
clearance of ~0.2 mL/hr/kg. Evaluation of the
biophysical characteristics of the molecules, such as charge,
non-specific binding, thermal stability, and hydrophobic properties, as
well as FcRn interaction characterization showed some differences.
In-depth drug disposition results revealed that poor physical stability
and incomplete release from FcRn are the primary factors these
contributed to the rapid clearance of the BsAb with aberrant PK.
Comparison of the Effect of Hydroxychloroquine Versus Favipiravir on SARS-CoV-2 PCR Conversion Time in Healthcare Workers with COVID-19
Authors: Çörtük Mustafa , Güvenç Unal , Sucu Pakize , Çeğilli Ercan , Başlılar Şeyma , Baydili Kürşad Nuri , Arslan Melih Akay , Kök Mualla , Çınarka Halit
Published: January 2024

Background and aim: Coronavirus disease 2019 (COVID-19) has spread
rapidly all over the world and has become a pandemic. Although negative
reports have been reported about the use of hydroxychloroquine (HCQ) in
patients with moderate to severe disease and hospitalized COVID-19
patients, its effect on RT-PCR negativity is unknown, mostly in mild
disease and outpatients. In this study, the effects of HCQ and
favipiravir on RT-PCR negation were compared. Methods: In this
multicenter, retrospective, cross-sectional study, consecutively
presenting COVID-19 patients who were positive for RT-PCR between 13
March 2020 and 15 January 2021 were analyzed. Negative RT-PCR results
and times were recorded in the follow-up of the patients. All of the
patients included in the study consisted of heathcareworkers and the
patients were divided into two groups as HCQ or favipiravir users.
Results: The favipiravir and HCQ patient groups were similar in terms of
age, gender, comorbidities, and hospitalization rate. The median number
of PCR-negative cases on the seventh day of treatment was significantly
higher in the HCQ group (p = 0.007). The median RT-PCR negation time was
9 days in the HCQ group versus 10 days in the favipiravir group (p =
0.006). Conclusion: The use of HCQ shortens the RT-PCR negative time
compared to favipiravir in patients who are in the relatively young age
group and have a definite diagnosis of COVID-19. This result is
important in terms of viral spread and contamination. There were no side
effects that required a change in treatment in either drug group.
Acute megakaryoblastic leukemia mimicking a disseminated tumor
Authors: Lam Suet Ying , Ha Shau Yin , So Chi-Chiu , Cheuk Ka Leung , Chow Terry TW
Published: January 2024

Acute megakaryoblastic leukaemia is an uncommon form of paediatric
cancer. Extramedullary leukaemia in acute megakaryoblastic leukaemia is
rare, which is reported to be associated with increased risk of
induction death. This atypical presentation makes diagnosis difficult.
Tissue biopsy from extramedullary site tumour can mimic other small
blood cell tumours. This report describes a case of this rare
presentation in a very young girl who presented with abdominal
distension as if she had metastatic solid tumour.
Adjuvant technologies in Medical History Taking: A historical overview
Authors: Neto Helio Rocha , Cavalcanti Maria , Telles-Correia Diogo
Published: January 2024

Introduction: History taking (HT) is the basis for medical practice.
Although its format lacks a standard, many HT tools (HTT) were
developed, applied, and automated throughout history. Our aim is to
build a history line about HTT development and its pros and cons.
Method: We accessed Medline and LILACS database through the BVS search
engine, using HTT equivalents in English, Portuguese, French, Spanish,
and German. Original papers and reviews about HTT aiming general
practice were selected, and their content comprehensively analyzed and
discussed, following PRISMA guidelines. Results: From 24904 initial
entries about HT since 1900, 105 were selected for analysis. First HTT
was identified before the 1st World War, mainly as mental screening
tools. Later, other general practices HTT were developed, integrating
statistical and branching reasoning. Two advantages were consistently
reported about clinician time saving and improvement on information
gathering. However, their use did not become widespread, restricted to
research scenarios and specific guidelines for clinical intervention.
Conclusions: HTT benefits may result from the systematization of HT, and
it is not clear if it results in economic and quality of care
improvement. However, systematization of HT and the use of computational
processing power may help medical practice and should not be overlooked.
Better comprehension of the diagnostic HT clinical act will help
comprehend how HTT may be useful for clinical practice, reasoning and
doctor patient relationship.
New interpretation of TB-IGRAS quantification of peripheral blood IFN-γ in the progression of lung cancer
Authors: Peng Yizhi , Yin Sheng , Wang Min
Published: January 2024

Abstract: Objective: To explore the new interpretation of quantification
of peripheral blood IFN-γ by TB-IGRAS in various cancers and the
progression of lung cancer ; Methods: A total of 389 patients and 127
healthy volunteers admitted to the Second Xiangya Hospital from June
2018 to April 2021 were recruited, including 259 patients with lung
cancer, 27 patients with liver cancer, and 103 patients with hematologic
tumors. 10mL heparin sodium was collected for anticoagulation and
TB-IGRAS was performed within 24 hours. SPSS version 26.0 software was
used to analyze these results . Results: The concentrations of IFN-γ in
healthy control group, lung cancer group, liver cancer group and
hematological malignancy group were 517.91(352.83-750.75),
1022.61(253.41-2872.23), 2764.87(953.23-7084.61) and
11106.41(259.41-3326.28)pg/mL, respectively. The IFN-γ concentration in
lung cancer group was higher than that in healthy control group (P
<0.001), liver cancer group (P =0.01) and hematological
malignancy group (P < 0.001). The concentrations of IFN-γ in
the non-metastatic lung cancer group and the metastatic group were
2893.57(1092.94-7592.89) pg/mL and 1554.63(308.43-4927.04) pg/mL,
respectively, the concentrations of IFN-γ in the non-metastatic group
were higher than those in the metastatic group (P <0.001).
Conclusion: The quantification of IFN-γ produced by peripheral blood T
cells after PHA stimulation by TB-IGRAS test might explain, to some
extent, the different responsiveness of various cancers to ICI
treatment. Monitoring lung cancer patients might help to judge whether
they have a tendency to further metastasis.