bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanocurcumin Potential Effect of SOD Enzyme and Caspase-3 Expression in Lead-Acetate Induced Rats Ovarian Granulosa Cells
Authors: Anis Satus Syarifah  , Sri Agus Sudjarwo  , Hendy Hendarto  , Reny I’tishom  , Supriyanto
Published: April 2021

Aim: This study investigated the potential effect of nanocurcumin on the increase of SOD enzyme expressionand decrease of caspase-3 in lead acetate-induced rats ovarian granulosa cells.Materials and Methods: Forty five female rats were divided into 5 groups, the negative control group (ratsreceiving corn oil, one hour later receiving distilled water), positive control group (rats receiving corn oil,one hour later receiving lead acetate of 40 mg/kg bw) and experimental groups 1, 2 and 3 (rats receivingnanocurcumin 50 mg, 100 mg and 200 mg/kg bw). One hour after administering the nanocurcumin, therats received 40 mg/kg of lead acetate. All groups received oral treatment once a day for 26 days. Onday 27 the rats were sacrificed and the expression of SOD and caspase-3 enzymes were measured usingimmunohistochemical methods.Results: This study found that lead acetate decreased SOD enzyme expression and increased caspase-3. Incontrast, nanocurcumin increased SOD enzyme and decreased caspase-3 expression in lead acetate-inducedrats ovarian granulosa cells.Conclusion: Nanocurcumin has potential as a strong natural antioxidant by affecting the increase of SODand the decrease of caspase-3 cells in lead acetate-induced rats ovarian granulosa cells.
The Influence of Roleplay Simulation on the Moral Development of Children Aged 8-9 Years Old
Authors: Aris Kurniyanto  , Ahmad Yusuf
Published: April 2021

Background : A lack of moral development might increase negative moral behavior. Drama, as a part ofrole-play, can stimulate the moral development of children aged 8-9 years.Objective : The purpose of this study is to explain the effect of role-play on the moral development ofchildren aged 8-9 yearsMethod : This research applied pre-experimental one-group pre-post test design. The population in thisstudy was children aged 8-9 years with a total of 47 children. A sample of 15 respondents was taken usingpurposive sampling. The independent variable in this study is role-play stimulation, while the dependentvariable is the moral development of children aged 8-9 years. Data collection was done using observationsheets, then analyzed using Wilcoxon Signed Rank Test with significance ? = 0.05.Result: Wilcoxon Signed Rank Test shows that stimulation through role-play can influence the moraldevelopment of children aged 8-9 years with p = 0.001.Conclusion: The results of this study conclude that role-play stimulation can improve children’s moraldevelopment.
Toothbrushing And Dietary Behavior of Children Aged 3–6 Years with Early Childhood Caries in Impoverished Community of Semampir District, Surabaya
Authors: Ardianti Maartrina Dewi  , Satiti Kuntari  , Tania Saskianti  , Berliana Ayu Prawesti Permatasari  , Adinda Putri
Published: April 2021

Objective: This research aimed to observe tooth brushing and dietary behavior of children aged 3–6years with early childhood caries (ECC) in impoverished communities, Semampir District, Surabaya City.Materials and Methods: This was descriptive observational with cross-sectional design study in 50 samplesof mother whom their children diagnosed with ECC. Research instrument using questionnaires based oncaries risk assessment (CRA) which modified. Results: Most samples showed good tooth brushing behavior,which includes brushing frequency and duration, routines using toothpaste, had tooth brushing initiative andindependently brushing teeth. The majority of samples had poor dietary behavior which includes snackinghabit frequency, time management, fruit and milk consumption. Conclusion: Most children aged 3–6 yearsin impoverished communities, Semampir District of Surabaya already had good brushing teeth behavior, butthey had poor diet which explain high prevalence of caries.
GPx1-rs1050450 Gene Polymorphism Association with End Stage Renal Disease in Type2 Diabetic Patients of Babylon Province/Iraq
Authors: Asma’a H. Mohamed  , Ali H. Al-Saadi  , Haider K. Zaidan
Published: April 2021

Background: Glutathione Peroxidase-1 is an antioxidant enzyme, play an important role in defense againstoxidative stress. In Pro198Leu (C/T) polymorphism of Glutathione gene variation which result in loweringenzyme activity increasing microvascular complications of diabetic patients. Aim: This study was aimed toestimate the relationship between GPX1 gene variation and the risk of develop and progression of end stagerenal disease in type I diabetic nephropathy patients. In this study, it has been examined 140 type I diabetesmellitus patients with nephropathy and 40 healthy control. Results: All samples have been genotyped byusing polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques.In diabetic nephropathy patients, there were a significant elevation in in the variation (TT) genotype and (T)allele frequencies compared with control group.Conclusions: Using major Iraqi diabetic patients of Babylon province we studied the transforming effect ofGPX1 gene polymorphism on the risk of development diabetic nephropathy, this study was found that the(TT) genotype of GPX1 SNPs increases the risk of development diabetic nephropathy, while (CC) genotypedecreases the chance for developing disease. These results will gave the way for better perception of thegenetic influencing on the development and progression of diabetic nephropathy.
Requirement Specification to Develop Digital Health Promotion Platform for Millenial and Post-Millenial Generations in Surabaya Indonesia
Authors: Atik Qurrota A’Yunin Al-Isyrofi  , Sri Widati  , Rachmat Hargono
Published: April 2021

Background: Surabaya is facing various urban problems that are increasingly complex. Therefore,innovative solutions are needed such as digital health promotion for millenial and post-millenial as thelargest segment of internet users. The aim of this study is to identify the requirement specification to developdigital health promotion platform for millenial and post millenial generations in Surabaya.Methods: This research used qualitative methods with case study approach. This study used purposefulsampling on 24 informants, consists of several related parties who met the criteria. Data collection techniquewas carried out through in-depth interview and documents review.Results: The requirement specifications were classified into 4 domains (functional, technical, interface,performance requirements). Functional requirements consist of procedures, menus, features, content, data,information, control mechanism, and parties involved. Technical requirements include programs, networks,size, and types of digital devices. Interface requirements consist of visual display related to user interfaceand operating system. Performance requirements include several aspects such as speed, accuracy, efficiency,effectiveness, security, etc.Conclusion: Digital health promotion platform requirement specification must be tailored to the needs ofmillenial and post-millenial generations. If these requirements can be met, the target will be easier to acceptand use digital health promotion platform.
Pathophysiology of Sickle Cell Anemia : Review Article
Authors: Ghusoon G Al- Janabi  , Ali A. Al-Fahham  , Ruqaya kareem Mohammed
Published: April 2021

About 5–7% of the world population have an unhealthy hemoglobin (Hb) gene . The most common form ofhemoglobinopathy globally is sickle cell disease. Sickle cell disorder (SCD) is the major predominant innateclutter of Hb amalgamation stamped through a change within the ? globin gene, which result within thesubstitution of glutamate corrosive with valine at the 6th codon and union of Hb S a which is a hemoglobin,beneath hypoxic states, coming about within the abnormality of RBCs (Red Blood Corpuscles). The lysis oferythrocytes result in raise in extracellular hemoglobin, hence hoisting liking and official to open nitric oxideor antecedents of nitric oxide in this manner diminishing its levels and assist partaking to vasoconstriction .Sickle ruddy blood cells since of their hardness to stream by means of the micro-circulation, results in visitvaso-occlusive scenes, destitute micro-vascular blood stream, ischemic damage, and myocardial localizednecrosis . The clinical highlights of sickle cell anemia are constant hemolytic weakness, an elevatedvulnerability to diseases, repetitive difficult Vaso-Occlusive Emergency (VOC) and a brought down lifehope .
Profile of Determinant Factors on Drug Allergy Severity in Indonesian Children at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Authors: Bagas Triambodo  , Azwin Mengindra Putera  , Bambang Hermanto
Published: April 2021

Background: Drug allergy in children is a rare case that needs special attention. Identifying the factorsthat affect the severity of drug allergy is important for the improvement of drug allergy management inIndonesian children. Objective: to analyze the factors that influence drug allergy severity in Indonesianchildren. Methods: This study used a retrospective design and consecutive sampling in 2014-2018. The datacollected included sex, types of allergy-causing drugs, previous allergy history, parental allergy history, andclinical manifestations. The data were analyzed by using a logistic regression test where the statistical testresults were significant if p <0.05. Results: The average age of the participants was 93.00 ± 50.54 monthswith a median value of 84 (12 - 204) months. Drug allergy severity in children is influenced by severalthings, such as the type of drug (? = 5.76; 95% CI 1.29 - 25.70; p = 0.022), sex (? = 1.27; 95% CI 0.30 - 5.36;p = 0.743), previous allergy history (? = 2.44; 95% CI 0.10 - 58.67; p = 0.583), and a drug allergy history onparents (? = 0.65; 95% CI 0.06 - 6.75; p = 0.719). Conclusion: There is a significant relationship betweendrug allergy severity and the type of drug whereas sex, previous allergy history, and a history of allergy onparents do not find a significant connection.
Assessment of Psychological Wellbeing Among Elderly Residents at Nursing Homes in Middle Euphrates
Authors: Bashaer Mohsen Ali  , Ali Kareem Al-Juboori
Published: April 2021

As people get older, may show shifts in the main sources that contribute to their well-being, in responseto the changing circumstances and abilities inherent in aging. The relocation to care homes considered asstressful event for the elderly people. A descriptive study is carried throughout the present study in orderto achieve the early stated objectives. The selection of the sample through a non - probability purposivesample consist of 60 elderly persons that are selected from the total population of elderly residents at nursinghomes. The data is collected by means of Ryff scales of psychological well-being (shorten version) . Thedata is collected by using structured interview technique with the elderly residents in nursing homes. Theanalysis indicates that the highest percentage of the elderly’s group have moderate level of psychologicalwellbeing (mean of score=3.29) (81.67%). The level of psychological well-being is affected by their gender.The study recommends to focus on managing the problems existing among the elderly and monitoring theirpsychological state.
Assess Nurses Knowledge Regarding Extravasation NonCytotoxic Medication in Baghdad Teaching Hospital
Authors: Batool Kadham Hussin
Published: April 2021

Background: vesicant no cytotoxic drugs are used broadly in present medicine for therapy changes conditionin hospitals most of them are registered to be peripheral cannulation. According to the literature, one vitalcomplication caused by cannulation applied for intravenous fluid therapy is extravasation.Objectives: to estimate knowledge about extravasation no cytotoxic drags.Methodology: A non-experimental design was carried out to evaluate the registered nurse’s knowledgeregarding extravasation non- cytotoxic medication in Baghdad teaching hospital an indiscriminate sampleconsisting of 100 nurses was selected, and a questionnaire was distributed to measure their knowledge of thesubject of the research. The statistical program version 23 Spss was used. The Results: were the majorityof females with 60% and the rest males. Most of the study participants (55%) were ages between 20 and29 years old. Study participants’. (43%) of the were secondary nursing school. The majority of participants(37%) experienced in hospital wards between 1-5years.Conclusions: The current study concluded that most of the member’s nurse’s deficiency necessary knowledgeabout extravasations of no cytotoxic medications. this study recommends that nurses have to participate inmore in-depth educational programs
Study on the Factors for Reporting Nosocomial Infections in Hospitalized Patients
Authors: Chaib Yassine  , Elanssari Anas  , Aouane Mahjoub  , Hamama Samir  , Chakhtoura Khalid  , Abdelmajid Soulaymani
Published: April 2021

Reporting nosocomial infections (NI) is a goal of alert and awareness, and an essential link in the currentpolicy of controlling health risks.From the health professionals and health authorities point of view, the reporting objectives are to set up analert system allowing the quick detection of unusual INs, and to verify, if necessary, that corrective mesuresare implementedThe present study did not fail to highlight a set of factors influencing the non-reporting of (NI) among thecaregivers at El Idrissi Hospital in Kenitra, namely : a) personal factor, b) organizational factors and, c)institutional factorsThe NI reporting plays an important role in the prevention of infectious risks, in the improvement of thequality of care. Thus, it would be intersting to examine the factors related to the non-reporting of NI
The Effect of Amniotic Membrane Stem Cell Metabolite Product (AMSP-MP) Combine with Vitamin E after Microneedling in Photoaging Progress
Authors: Cita Rosita Sigit Prakoeswa  , Agatha Anindhita Ayu Ardhaninggar  , Riyana Noor Oktaviyanti  , Irmadita Citrashanty  , Maylita Sari  , Menul Ayu Umborowati  , Dwi Murtiastutik
Published: April 2021

Introduction: The photoaging is a cumulative process. Amniotic Membrane Stem Cell Metabolite Products(AMSC-MP) that contain cytokines and growth factors that have a role in the skin’s rejuvenation process.Vitamin E is an antioxidant that has a photoprotective effect. Topical combination of AMSC-MP and VitaminE are expected to have an effect on clinical photoaging improvement.Objective: To evaluate the effect of topical combination of AMSC-MP with vitamin E after microneedlingcompared with AMSC metabolite products after microneedling.Methods: A total 60 photoaging women were included in this experimental analytic, controlled, matchingresearch. Each participant’s face was allocated to topical combination of AMSC-MP and vitamin E inintervention group and AMSC-MP only in control group. Microneedling modality was use to enhanceepidermal penetration. Three treatment sessions were repeated at two weeks’ interval.Results: From the comparison of the two groups showed there were significant different of mean value inwrinkle, skin tone and UV spots with p-value < 0,005 in the intervention grup. While pore and polarized spotdo not show significant differences between two groups.Conclusion: The administration of a topical combination of MP-AMSC and vitamin E after microneedlingprovides clinical improvement in photoaging.
Severe Pneumonia: Etiology and Outcome in a Tertiary Hospital in Indonesia
Authors: Daniel Maranatha, Mawardi  , Hamzah
Published: April 2021

Background: Severe pneumonia represents a subset of life-threatening pneumonia. The mortality rate ofpatients with severe pneumonia is considerably high. This study aims to determine the etiology and outcomeof severe pneumonia.Methods: An observational prospective study was conducted from September 2017 to September 2018 onpneumonia patients in a tertiary hospital. Clinical and diagnostic evaluations were carried out to assess theseverity of the disease, etiology, comorbidities, and several other factors associated with outcomes.Results: 140 pneumonia patients were evaluated and 41 patients met the severe pneumonia criteria. Apathogen was found in 20 community-acquired pneumonia (CAP) and 13 hospital-acquired pneumonia(HAP). The most frequently isolated pathogen from the sputum culture of patients with either severe CAPor HAP was Acinetobacter baumannii. The mortality rate of severe HAP patients was higher than thatof severe CAP patients (84% vs. 65%), but the difference was nonsignificant. Most of the subjects hadcomorbidities (CAP 75%, HAP 61.6%). Procalcitonin (PCT) and C-reactive protein (CRP) levels in severeCAP were higher than those in severe HAP (PCT 7.7 vs 6.0, p=0.658; CRP 163.1 vs 93.6, p=0.580), but thedifferences were also nonsignificant.Conclusion: The most frequently isolated pathogens from the sputum culture of patients with severepneumonia were Acinetobacter baumanii, which should be considered at the time of diagnosis and empiricalantibiotic therapy. Severe pneumonia was often accompanied by comorbidities, inflammation responsesincrease in both severe CAP and HAP with a high mortality rate.
Comparison the Serum Level of Paraoxonase Activity in Frequent Relapse and Infrequent Relapse Patients with Nephrotic Syndrome
Authors: Dhuha A. Hussain  , Sinan A. Ibrahim  , Raid J. Mohamed
Published: April 2021

Nephrotic syndrome (NS) is distinguished by heavy proteinuria (urine protein:creatinine ratio ?2000 mg/gor ?300 mg/dL, or 3+ protein on urine dipstick), hypoalbuminemia (?2.5 g/dL), and edema. Leakage ofmassive amounts of serum proteins into the urine leads to a hypercoagulable state, a higher rate of infectiousdisease, and the dysregulation of fluid balance. Idiopathic nephrotic syndrome (INS)is one of the most common renal problems in children encountered in day-to-day nephrology practices.The present study was aimed to evaluate the oxidant/ antioxidant status by measuring paraoxonase (PON)activities as well as total antioxidant capacity in steroid sensitive nephrotic syndrome (frequent and infrequentrelapse) and compares it with healthy control children . Paraoxonase activity by spectrophotometer in threegroups consisted of age and sex matched (30) patients with Frequent relapse nephrotic syndrome FRNS ,(30) patients with infrequent relapse nephrotic syndrome (IFRNS) and (30) healthy control children. Theserum level of paraoxonase activity in infrequent relapse group was 101.61±43.0 IU which far less thanfrequent relapse group (160.44±44.22 IU) or controls (228.35±32.35 IU) with highly significant differences.Of note, the difference between control group and frequent relapse group was highly significant.
Effect of Cyanide on the Liver Histological and Biochemical Status
Authors: Dhurgam Jameel Mohamed  , Ghusoon G Al- Janabi  , Abbas Natroud Bashi
Published: April 2021

The biochemical and histological response of the rats following dosed on the potassium cyanide wasexamined in this study, about 36 rats were randomly divided into sex groups ; G0 which considers the controlgroup, G1 oral dosed with potassium cyanide concentration 500ppm (500U/L), G2 dosed with concentration1000ppm (1g/L), waiting for a long time 21 days before anatomy the animal. G3, G4, and G5 dosed with2000ppm, 2500ppm, and 3000ppm, respectively to study the effect of high dose concentration on the liverhistology, liver enzyme and lipid profile and determined LD50 (lethal dose), and LC50 (lethal concentration).After anatomy, the animal experiment to study the liver histological and determine the effect of potassiumcyanide concentration on the liver enzymes such as HDL, triglyceride, and cholesterol, compared the resultwith the control group and previous studies . The study indicated the presence of a significant increase (P?0.05) in ALP in the G1 , a non-significant increase (P? 0.05) in the G2 , the G3 and G4 groups suffered froma significant increase (P? 0.05) while the G5 group suffered from a non-significant decrease (P? 0.05) incomparison with G0. The present study also showed that there was a significant increase (P ? 0.05) in GPT inthe G1 , G2 , G3 , G4 in comparison with G0. The study also indicated the presence of a significant increase(P ? 0.05) in GOT In the G1 , G2 and G3 compared to the G0.
Ketogenic Diet Slows Down Weight Gain in Juvenile Mus musculus with Benzopyrene as Cancer Inducer
Authors: Dita Mega Utami  , Lilik Herawati  , Reny I’tishom  , Mohammad Anam Al-Ari  , Muhammad Miftahussurur  , Purwo Sri Rejeki
Published: April 2021

Objective: This study aims to analyze the ketogenic diet that slows down weight gain in juvenile Musmusculus induced with benzopyrene (BZP). Method: Thirty-six female mice (Mus musculus), 6-8 weeks old,weighted 15-25 grams were divided into six groups randomly. K1 (negative control, standard diet) inducedwith oleum olivarum, while K2 (positive control, standard diet), P1 (ketogenic diet 1), P2 (ketogenic diet 2),P3 (ketogenic diet 3) and P4 (ketogenic diet 4) induced with BZP subcutaneously in the right breast at a doseof 0.3mg/20gBB/day for 14 days. The ketogenic diet was given for the next 28 days. Data were analyzedusing the ANOVA and post hoc LSD test. Results: After 42 days, the ketogenic diet mice experiencedslower weight gain (p=0.000) because BZP induced neurotoxicity and the administration of the ketogenicdiet in juvenile mice induced neurohormonal changes. The ketogenic diet increased ketone plasma level(p=0.000) and reduced blood glucose levels (p=0.002) due to nutritional ketosis state. Conclusions: Theketogenic diet with fat:protein ratio 60:30 slows down weight gain, increased ketone levels and decreasedblood glucose levels in juvenile mice with BZP as cancer inducer.
Factors Related to Postnatal Care Utilization in Indonesia in 2018: An Ecological Study
Authors: Eni Purwaningsih  , Hario Megatsari  , Agung Dwi Laksono  , Mursyidul Ibad
Published: April 2021

Postnatal care is very crucial in the postnatal period because it is a critical period for babies. This study aimsto analyze the factors related to postnatal care utilization (1st neonatal visits) in Indonesia. The ecologicalanalysis was conducted using secondary data from the Ministry of Health of the Republic of Indonesiareport in 2018. All provinces were taken as samples. Apart from postnatal care utilization, 5 other variablesanalyzed as independent variables were the ANC 1st visit, ANC 4th visits, poverty depth index, percentageof health centers with sufficient midwives, and the ratio of gynecologist per 100,000 population. The resultsshow there was a tendency for a positive relationship between ANC 1st visit and 1st neonatal visit. The higherthe ANC 1st visit coverage, the higher the 1st neonatal visit coverage (p = 0.034). Meanwhile, there was alsoa trend towards a positive relationship between the ANC 1st visit and the 1st neonatal visit. The higher thecoverage of the ANC 4th visit, the higher the coverage of the 1st neonatal visit (p = 0.040). Moreover, povertydepth index, percentage of health centers with sufficient midwives, and the ratio of gynecologist per 100,000population were found to have no significant correlation with 1st neonatal visits. It could be concluded thatfrom the 5 independent variables analyzed, 2 variables were proven to be ecologically positively related topostnatal care utilization (1st neonatal visit), namely ANC 1st visit and ANC 4th visit.
Alveolar Bone Density after the Orthodontic Treatment in Patients of Rsgm Universitas Airlangga
Authors: Ernie Maduratna Setiawatie  , Mohamad Rubianto  , Muhammad Naufal Ilmi Roswand
Published: April 2021

Background: There is a relation between the orthodontic therapy and the periodontal tissue. In the movingteeth and planning treatment, the periodontal tissue is very influential in an orthodontic therapy. During themovement of the teeth, all components of the periodontal tissue such as the bones, periodontal ligaments,and gingiva will change and move together. Some studies indicate a decrease in alveolar bone fraction andalveolar bone density. The changes in density are seen by comparing the new bone mineralization withthe old bones. Purpose: This research aims to analyze the differences in alveolar bone density after anorthodontic treatment in patients of RSGM Universitas Airlangga. Methods: This study used a patient’spanoramic radiograph at the time before the orthodontic treatment and the time after it. Photographs ofpanoramic radiographs were measured using a digital densitometer. Results: The results of the studyrevealed a decrease in alveolar bone density after orthodontic treatment, both anterior and posterior. Theaverage decrease in the anterior was 35.4%, while in the posterior was a decrease of 31.5%. Conclusion:There was a decrease in the alveolar bone density after orthodontic treatment in the anterior and posteriorsections.
Improving Mental Health of Adolescents through Self-Presentation
Authors: Ferina Agustia Yuarta  , Ira Nurmala
Published: April 2021

Mental health is currently the problem faced by youth especially during the pandemic of COVID-19.Adolescents use of social media is also increasing due to this coronavirus pandemic. This situation have riskof increasing the risk of lower mental health of Adolescent as the impact of posting their self-presentationthrough a social media such as Instagram. Instagram is a social media platform that has a rapid user growth.Indonesia is one of the countries with highest number of users. Instagram users recorded as of May 2020had reached 9.2 million users. Instagram as social media is a means for users to present themselves towide audience. Self-presentation can be in the form posting photos or videos on their Instagram socialmedia accounts. By posting photos, user hope to get feedback in the form of likes and comments. Thisresearch aims at the improving mental health of adolescent through self-presentation. This research usedis secondary data obtained from journal database. The sample was 35 scientific articles obtained from thebasis of screening journal that has been screened using pre determine inclusion criteria. The result found thatself-presentation on social media Instagram was related to giving or managing impression, popular, selfdisclosure, narcissistic behavior, self-image and self-esteem that in turn will result in lowering adolescentmental health if it is not manage well.
Comparison of Palatal Rugae Pattern among Indian and Malaysian Population
Authors: Firoz Ismail  , Rejeeh.E.P  , Rajesh.H  , Nabeel Abdul Vahid
Published: April 2021

Background: Tools for establishing identity is invaluable part of forensic sciences form the beginningof the profession. Odontology is one of such branches which in early days started in its crude form withidentification of different species and races within the species, currently is an individual subject withspecialist societies, journals and courses. Palatal rugae, was identified to be a potential tool for establishingidentity few centuries back itself but is not validated even today to be part of standard protocols. This is apilot study comparing two racial groups i.e., Indian and Malaysian with established parameters for palaterugae aiming at testing the feasibility of the parameters to be used in identification of individuals and racialgroups and also to provide preliminary data to make way to larger studies.Aims and Objectives: The aim of this pilot study is to explore the feasibility of palate prints as tool foridentification by, studying palate print in Indian and Malaysians and Comparison of plate Rugosity betweenIndians and Malaysians students for identification.Methodology: Study population was male Indian and Malaysian Medical and Dental students, age between18-25 years studying at Mangalore, India. Sample size 80 (40 in each group); were selected for studying ofPalatal Rugae. The palate impressions were collected using maxillary alginate cast. The parameters assessedwere: Total number of rugae, number of primary rugae (length- 5 to 10 mm), secondary rugae (3-5mm),fragmentary rugae (less than 3 mm). Comparison for two populations was done using non-parametric MannWhitney Test.Results: There were no statistically significant differences among the Indians and Malaysians in totalnumber and number secondary rugae in both sides more in Indians than Malaysians.There was statistically significant difference in number of the primary rugae and the fragmentary rugae,which in both sides were more in Indians than Malaysians.Conclusion: In conclusion, palatal rugae pattern are unique to an individual and their use in forensicidentification has been advocated and applied. Our study demonstrated significant difference in the numberof primary rugae on each side. It was more in Indians than Malaysians. This study demonstrated theuniqueness of rugae pattern in different individuals. Thus, it appears to be an effective & reliable source ofidentification.
Shape and Unification Pattern of Palatal Rugae as a Race Identification Tool- A Cross-Sectional Study
Authors: Firoz Ismail  , Rejeesh.E.P  , Rajesh.H  , Nabeel Abdul Vahid
Published: April 2021

Background: One of the integral parts of forensic medicine is identification of individuals from biologicalsamples and from the anatomical signatures. Identification of individuals, races, species, gender from theanatomical signatures of teeth and oral cavity is one of such branches which existed in practice in crudeform even before origin of the Forensic odontology as a specialization. Individual variations in Palatal rugaepattern, and its biometric value as a potential tool for establishment of identity was reported centuries back. It’snot standardised or included in the regular standard protocols even today in the age of artificial intelligence.In this pilot study we are comparing two racial groups i.e., Indian and Malaysian with established parametersfor palate rugae with an objective of testing feasibility and validation for identification of individuals andracial groups and also to provide preliminary data for larger studies.Aims and Objectives: The aim of this pilot study is to explore the feasibility of palate rougoscopy as a toolfor race identification by studying the shape and unification Pattern of Palatal Rugae in Indian and Malaysianpopulation.Methodology: Study population was male Indian and Malaysian Medical and Dental students, aged 18-25years studying at Mangalore, India. Sample size 80 (40 in each group); were selected for studying PalatalRugae. The palate impressions were collected using maxillary alginate cast. The parameters assessed were:shape an unification based on classification of Thomas & Kotze. Comparison for two populations was doneusing non-parametric Mann-Whitney Test.Results : Predominant Shape: The Curvy patterns were more common in Malaysians compared to Indian.The Wavy patterns were more common in Malaysians than Indians.The Circular patterns were more commonin Indians than Malaysians.Predominant unification: Diverging patterns were more in Malaysians than Indians and Converging patternswere more in Indians than Malaysians and statistically significant.Conclusion : In the present study the Malaysians had predominantly curvy and wavy patterns and Indianshad circular shapes. Straight patterns were seen equally in both the populations. Although unification ofthe palate rugae was seen, the diverging patterns is more in Malaysians and Converging patterns more inIndians.
The D614G Mutation in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Glycoprotein: A MiniReport
Authors: Arif Nur Muhammad Ansori
Published: April 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a quickly spreading virus that posesa major burden on global human health. Thus, it is essential to develop COVID-19 vaccines. Vaccinedevelopment might not be easy, as a consequence of mutations. This study aimed to demonstrate the D614Gmutation in SARS-CoV-2 spike glycoprotein from Indonesia. 102 isolates from the GISAID EpiCoVdatabase and the Wuhan-Hu-1 isolate (reference sequence) from GenBank, NCBI were used in this study.BioEdit employed to examine the D614G mutation in the spike glycoprotein of SARS-CoV-2. In this report,there are 56 D614G mutations among 102 SARS-CoV-2 isolates. In summary, this report might suggestthat the D614G mutation implicates the COVID-19 pandemic in Indonesia. Nevertheless, this report was apreliminary study and this study recommends expanding molecular epidemiology and surveillance programsto monitor COVID-19
Discovery of Therapeutic Targets and Potential Drugs to Fight Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2): A Review
Authors: Arif Nur Muhammad Ansori
Published: April 2021

SARS-CoV-2, the causative agent of COVID-19, has led to more than two million deaths worldwide. Thereare currently no specific therapies approved to treat COVID-19 and drug repositioning, rather than newdrug discovery, which may be the best short-term option for controlling the pandemic. In this review, theauthor discusses important viral targets such as the papain-like protease, RNA-dependent RNA polymerase,3-chymotrypsin-like protease, and spike protein. The information about chemical compounds and targetsprovided in this review will aid further in vitro and in vivo studies to discover drugs to treat COVID-19.
Determinant of Intention E-cigarettes Use Among a Sample of Senior High School Students in Surabaya
Authors: Hendra Eka Alifiyanto  , Sri Widati  , Rachmat Hargono
Published: April 2021

Background: The prevalence of smoking in Indonesia in 2018 among adolescents (10-18 years old)was 9.1%. Surabaya has 9,28% of boys who are active smokers and acknowledged smoking everyday. Adolescents using conventional cigarettes are also tend to be interested to using e-cigarette.Objective: The aim of this study was to analyze the factors that associate the intention of e-cigarettes use inadolescents in Surabaya.Method: The type of study was observational analytic design with cross sectional. The sample size wasdetermined by cluster random sampling, in 8 school which includes 291 students. Data collection wasthrough filling out the online questionnaire and analyzed using logistic regression test to determine theassociation between variables.Results: This results of this study show that the factors that have positively associated to intentions ofe-cigarettes use by adolescent are instrumental attitudes (3,035), injunctive norm (2,561), descriptive norm(4,896) and self efficacy (3,526). Experiential attitude and perceived control did not associated the intentionof adolescents e-cigarette use.Conclusion: Providing education to adolescents, parents and educational stakeholders about the dangers ofusing e-cigarettes and restrictions on adolescents access to e-cigarettes should take considered the long-termimpact of e-cigarette.
A Prediction Model of Mortality in Patients Hospitalized with Diabetic Ketoacidosis in a Tertiary Referral Hospital in Surabaya, Indonesia
Authors: Hermina Novida  , Fajar Setiyawan  , Soebagijo Adi Soelistijo
Published: April 2021

Background: The mortality rate of diabetic ketoacidosis (DKA) remains high in Indonesia. Differentpatterns were contributing to DKA mortality from previous studies. We aim to identify clinical and laboratoryfindings as mortality predictors of DKA.Methods: This retrospective study was conducted in a tertiary referral hospital in Surabaya. Medical recordsof DKA patients from January 2016 to December 2018 were analyzed. Clinical and laboratory data wereobtained from medical records for three years period. Clinical outcome was defined as either dischargedhome or death.Results: Fifty-six among 116 DKA patients did not survive during hospitalized. Age of 60 or older, thedepressed mental state with GCS below 13, potassium serum less than 3.5 mmol/L, and bicarbonate serumless than 15 mmol/L are found to be significant as independent factors of mortality in DKA patients.Conclusion: The mortality rate of DKA patients in this study is still high. It independently associatedwith the age of 60 years or older, depressed mental state, hypokalemia, and low bicarbonate level. Earlystratification of these predictors would help to treat patients accordingly.
Influence of the method of accounting for pore pressure in the water-resistant layer on the calculation of foundation precipitation
Authors:   NIIOSP named after N.M. Gersevanov JSC Research Center of Construction, Тrufanov Alexander
Published: April 2021

Рассматривается факторы, влияющие на расчет осадки фундамента условного здания в связи с учетом природного порового давления в водоупорных слоях. Приведено сравнение расчета осадки фундамента условного здания с учетом и без учета порового давления методом послойного суммирования и методом конечных элементов. Определены основные факторы влияния порового давления на величину расчетной осадки: размер сжимаемой зоны, модуль деформации и параметры переуплотнения грунтов. Отмечено разнонаправленное действие факторов на величину расчетной осадки.
Engineering method for calculating foundation settlements over the cavity resulted from dissolution of karst subjected rocks located under a hydraulic structure
Authors:   NIIOSP named after N.M. Gersevanov JSC Research Center of Construction, Potapova Evgeniya ,   Moscow State University named after M.V. Lomonosov, Kholmyanskiy Mikhail ,   NIIOSP named after N.M. Gersevanov JSC Research Center of Construction, Pushilin Andrey ,   NIIOSP named after N.M. Gersevanov JSC Research Center of Construction, Sarana Ekaterina ,   NIIOSP named after N.M. Gersevanov JSC Research Center of Construction
Published: April 2021

С применением модификации метода «типовых кривых», разработанного для прогноза осадок поверхности над подземными выработками, и с учетом результатов гидрогеологических фильтрационных расчетов проведено комплексное оценивание масштабов карстопроявлений и осадок основания гидротехнического сооружения. Карстовые полости полагаются образующимися вследствие процессов фильтрации воды в растворимой породе, подстилающей грунтовую толщу, на которую опирается фундамент сооружения. С учетом указанных условий предложена состоящая из дугэллипса модель формы сечения полости.Размеры полостей и вызываемые имиосадки поверхности основания оцениваются для различных участков основания с учетом распределения значений скорости фильтрации в породе и данных о переменной мощности защитного слоя глин. Прогнозируемые значения осадок предлагается использовать для обоснования необходимости противокарстовых мероприятий и для районирования их параметров.
Updating regulatory framework for underlying soil bases and foundations on permafrost soils
Authors:   NIIOSP named after N.M. Gersevanov JSC Research Center of Construction, Alekseev Andrey , Rabinovich Mikhail ,   Moscow State University of Civil Engineering (MGSU)
Published: April 2021

Prospects for the development of Russia’s northern territories requires active improvement of existing and development of new regulatory documents regulating the usage of permafrost soils as underlying soil bases for buildings and structures. The introduction of new materials and technologies, the arrival of modern technologies, machines and mechanisms to the construction industry, has exacerbated the need to revise the civil engineering regulatory framework concerning permafrost conditions.
Does signal reduction imply predictive coding in models of spoken word recognition?
Authors: Luthra Sahil , Li Monica Y. C. , You Heejo , Brodbeck Christian , Magnuson James S.
Published: April 2021

Pervasive behavioral and neural evidence for predictive processing has led to claims that language processing depends upon predictive coding. Formally, predictive coding is a computational mechanism where only deviations from top-down expectations are passed between levels of representation. In many cognitive neuroscience studies, a reduction of signal for expected inputs is taken as being diagnostic of predictive coding. In the present work, we show that despite not explicitly implementing prediction, the TRACE model of speech perception exhibits this putative hallmark of predictive coding, with reductions in total lexical activation, total lexical feedback, and total phoneme activation when the input conforms to expectations. These findings may indicate that interactive activation is functionally equivalent or approximant to predictive coding or that caution is warranted in interpreting neural signal reduction as diagnostic of predictive coding.
Community Based Tourism dalam Pengelolaan Desa Wisata Giriloyo, Wukirsari, Imogiri, Bantul
Authors: Suwarjo Suwarjo
Published: April 2021

The results of study showed that community-based community in Giriloyo Tourism Village can be used for all community of batik artisans community who joined in paguyuban batik. Community agility from the stages of planning, evaporation, to activities. Forum meetings from hamlet level, batik community to tourist village become a forum for the community to convey aspirations and campaigns-inspiring activities.  To motivate the community in Giriloyo Tourism Village, the following suggestions are offered: 1) the need for optimization of community meeting vessels to explore the potentials of interest for batik. Special tours special outbound and traditional culinary; 2) to increase the interest of the young generation of batik handicrafts in Giriloyo Tourism Village, can organize annual event with batik and staining pattern creations. Competition can be done in groups and there is no relationship that can be established relationships and close cooperation between adolescents.
Belenggu Patriarki pada Peran Laki-Laki Bangsawan Jawa dalam Film Kartini Karya Hanung Bramantyo
Authors: Marsya Ulmi , Faladhin Johan
Published: April 2021

The struggle of Raden Ayu Kartini to gain freedom for Javanese women who were hindered by the great walls of culture and tradition, often associated with patriarchal culture which was said to give more privileges to men than women. But in fact the privileges possessed by men instead of giving freedom, it also binds his mind to the true roles and behavior of men who have been established in the patriarchal culture itself.
Reformulasi Regulasi Radio Komunitas di Indonesia
Authors: Yudaninggar Kartika Sari
Published: April 2021

Community Radio (CR) in Indonesia has emerged as a media that able to disseminate information to audience. Since this function can not be fullfiled by both private and public radios, CR is important for audience especially for those who lives in remote or even blank spot area. However, Government regulation on CR is feared to deprive the existence of CR. The regulation ranging from limitation of frequency allocation, criteria on coverage area and limited emmitance strength compare to public and private radios.  This imply that the Government has never supported the existence of Community Radio. Government and Indonesia Broadcasting Commistion (KPI), as the powerful bodies, ought to reevaluate broadcasting regulation especially on Community Radio. Reformulation on the regulation is needed to maximilize the function of CR in Indonesia as independent media and to support democratization in the broadcasting system in Indonesia.
EFEKTIVITAS SOCIAL MEDIA INSTAGRAM #PASARSENENUKM TERHADAP PENINGKATAN PROMOSI UKM DI INDONESIA
Authors: Wardhani Alysha Tri , Uljanatunnisa Uljanatunnisa , Hendrayani Yani
Published: April 2021

#PasarsenenUKM Service is a service on Instagram social media that made public relations Ministry of SME and RI. The purpose this research is to know how much Social Media effectiveness Instagram #pasarsenenUKM to increase promotion of SMES in Indonesia. The theory used is The Hierarchy of Effects Concept, this theory explains the steps that consumers take to make decisions. The method used is quantitative with this type of an expreslanative research. The chosen population is an Instagram followers @KemenkopUKM as much as 186,000 people, using Yamane formula and then obtained the sample number of 100 respondents. This research uses questionnaire deployment techniques to get data. Based on the calculation  the test results T obtained t count 11.921 > T table 1.661, it can be concluded that Ho rejected and Ha accepted meaning that Social Media effectiveness the Instagram #pasarsenenUKM has significant influence on the improvement of SME promotion in Indonesia.
SOCIAL CLIMBER IDENTITY AND MEMORY : POTRET DIRI SEBAGAI OBJEKTIVITAS HIPERREALITAS KEHIDUPAN DAN DEGRADASI MEMORI
Authors: Yudhistira Nurfian
Published: April 2021

This study examines the development of photographic technology that facilitates the development of the phenomenon of social climbing by highlighting the hyperreality of social media, thereby resulting in the emergence of a new identity for social climbers. Photography technology has evolved over time. Digital technology has created instant technology that makes it easy for camera users to operate cameras with automatic adjustment features, therefore the technology industry is constantly looking for ways to develop and make smartphones. Smartphones integrate image and communication technology into one device, making it easier for users to communicate. This smart phone supports online access to social media because of its features that can be connected to the internet. So anyone can share their photography using this tool and also social media. social media makes it easy for everyone to access information including personal activities that are shared, so that phenomena that are often referred to as social climbing phenomena are phenomena marked by social media users who are competing to improve their social status on online social media. The phenomenon of social climbing makes someone create a new identity for themselves on social media. Creating a life that is exaggerated from its original reality or also called hyperreality. This study aims to provide education related to the use of photography and social media, so that people do not fall into the phenomenon of false identities in social media.
Alman Misyonerliğinin Yakın Doğu’daki En Büyük Müessesesi: Suriye Yetimhanesi (1860-1917)
Authors: Şi̇mşek Muttalip
Published: April 2021

19. Yüzyılın ikinci yarısı ile 20. yüzyılın ilk çeyreği, Osmanlı Devleti'nde Batılı misyonerlerin en faal olduğu zaman dilimini ifade etmektedir. Osmanlı sınırları içerisinde misyonerlerin en fazla önem verdiği bölgelerden birisi de, üç semavî din 368 TÜRKÇE ÖZETLER mensuplarınca kutsal kabul edilen Kudüs ve çevresidir. Alman misyoneri Johann Ludwig Schneller tarafından Kudüs'te kurulan Suriye Yetimhanesi, bölgede yürüttüğü misyon çalışmaları, bakımı üstlenilen çocuklara verilen eğitim ve kurumun bünyesinde oluşturulan akademik birimler, atölyeler ve tarımsal işletmeleri ile bölgenin en büyük misyon kuruluşu olmuştur. Yetimhane kurulduğunda sadece erkek çocukların bakımı sağlanırken kısa bir süre sonra yetimhaneye kızlar ile gözleri görmeyen çocuklar da alınmaya başlanmış ve bu çocukların temel eğitimden mesleki eğitimlerine kadar bütün ihtiyaçları burada karşılanmıştır. Yetimhaneye her din ve milletten çocuk alınmış, ancak Kudüs'te bir "Protestan Arap orta sınıfı" oluşturmayı hedefl eyen Schneller ailesi, yetimhanede kalan çocukların büyük bir kısmını Protestan yapmışlardı. Üstelik yetimhaneye ait atölye ve tarımsal birimler zamanla öylesine büyümüştü ki, bir hayır kurumu olarak tesis edilen Suriye Yetimhanesi, 20. yüzyılın başlarında pek çok alanda üretim yapan bir ticarî işletme haline dönüşmüş ve bölgede Alman nüfuzunun yer edinmesinde önemli bir rol oynamıştı.