bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Ambident Heterocyclic Reactivity: Alkylation of 2‐Substituted‐4‐ methylbenzimidazoles.
Authors: HAQUE M. R. , RASMUSSEN M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of Fused γ‐Lactams by Intramolecular Nitrone Cycloaddition.
Authors: CHIACCHIO U. , BUEMI G. , CASUSCELLI F. , PROCOPIO A. , RESCIFINA A. , ROMEO R.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of 2,3‐Dihydro‐3‐thioxo‐thienoisothiazole 1,1‐Dioxides with Diazomethane and Diazoethane.
Authors: UNTERHALT B. , MOGHADDAM S.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Biological Activity of Uncondensed 2‐Thiazolidones with Polymethylene Bridges.
Authors: ORLINSKII M. M. , ZIMENKOVSKII B. S. , STETS V. R.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Method for the Preparation of 2,2′‐Substituted‐2,3‐dihydro‐3‐ phenyl‐1,3,4‐thiadiazoles Using Trimethylsilyl Chloride.
Authors: MATSUBARA Y. , KITANO K. , TSUTSUMI A. , YOSHIHARA M. , MAESHIMA T.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrogeneration and Structural Discussion of 6‐Benzyl‐3,5‐ diphenylhydroxypyranones.
Authors: LOZANO J. I. , BARBA F.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Azacarbazoles.
Authors: BLACHE Y. , CHAVIGNON O. , SINIBALDI‐TROIN M. E. , GUEIFFIER A. , TEULADE J. C. , TROIN Y. , GRAMAIN J. C.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Reactions and Interconversions of Some 2‐(Trimethylsilyl) ethyl Substituted Sulfur Compounds
Authors: SCHWAN A. L. , BRILLON D. , DUFAULT R.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Method for Synthesis of 1‐Acylamino‐alkenylphosphonic Acids, Their Analogues and Derivatives.
Authors: BROVARETS V. S. , ZYUZ' K. V. , BUDNIK L. V. , SOLODENKO V. A. , DRACH B. S.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fluorene Ylides.
Authors: KOLODYAZHNYI O. I. , USTENKO S. N.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transformation Products of Sclareol. Part 15. Tetrahydrofuranyl Compounds with Rearranged Bicyclohomofarnesane Carbon Skeleton via Interaction of Bicyclohomofarnesane‐8α,12‐diol with Cationite KU‐ 23.
Authors: DRAGALIN I. P. , ZADOROZHNAYA L. A. , VLAD P. F.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Studies Toward Zoapatanol (I).
Authors: PAIN G. , DESMAELE D. , D'ANGELO J.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Base‐Catalysed Isomerization of Eugenol (I): Solvent‐Free Conditions and Microwave Activation.
Authors: LOUPY A. , LE NGOC THACH LE NGOC THACH
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Acetic Anhydride with Monoterpene Amine Oxides Possessing the 2,7‐Dimethyloctane Skeleton.
Authors: PETRUSHKINA E. A. , GALAKHOV M. V. , ZAKHARKIN L. I.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclopentaannulation of Podocarpic Acid Derivatives via (η6‐Arene) tricarbonylchromium(0) Complexes: Ring D Modification.
Authors: CAMBIE R. C. , RUTLEDGE P. S. , STEVENSON R. J. , WOODGATE P. D.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ring A Modification of Podocarpic Acid Derivatives: Functionalization and Cyclopentaannulation of Ring C via (η6‐Arene) tricarbonylchromium(0) Complexes.
Authors: CAMBIE R. C. , RUTLEDGE P. S. , STEVENSON R. J. , WOODGATE P. D.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of myo‐Inositol 1,4,6‐Trisphosphate, an Analogue of myo‐ Inositol 1,4,5‐Trisphosphate.
Authors: WATANABE Y. , OGASAWARA T. , OZAKI S. , HIRATA M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Macleanine, a Unique Type of Dinitrogenous Lycopodium Alkaloid.
Authors: AYER W. A. , MA Y.‐T. , LIU J.‐S. , HUANG M.‐F. , SCHULTZ L. W. , CLARDY J.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lupin Alkaloids. Part 6. Stereochemistry of Bis‐quinolizidine Alkaloids with γ‐Oxo‐α,β‐enamine System
Authors: BRUKWICKI T. , WYSOCKA W. , NOWAK‐WYDRA B.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regio‐ and Stereoselective Synthesis of Carbocyclic 2′,3′‐Dideoxy‐3′‐ fluoro Nucleosides as Potential Antiviral Agents.
Authors: NAKAYAMA T. , MATSUMURA Y. , MORIZAWA Y. , YASUDA A. , UCHIDA K. , TAKASE H. , MURAKAMI Y. , ATARASHI S. , IKEUCHI T. , OSADA Y.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of (8S, 9S, 11R, 12R, 15S)‐9,11‐Dideoxy‐9,11‐ ethanoprostaglandin‐H2.
Authors: VALEEV F. A. , GAISINA I. N. , MIFTAKHOV M. S. , TOLSTIKOV G. A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Actinomycin Analogs. Part 18. Actinomycin Derivatives Containing Bithiazole Fragments of Bleomycin.
Authors: BANNIKOV S. E. , ANDRONNIKOVA G. P. , GLIBIN E. N.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cytotoxic 6‐Substituted 5,6‐Dihydro‐2H‐pyran‐2‐ones (I) from a Brazilian Medicinal Plant, Chorisia crispiflora.
Authors: MATSUDA M. , ENDO Y. , FUSHIYA S. , ENDO T. , NOZOE S.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Directions in Intercalation Research
Authors: DRESSELHAUS M. S. , DRESSELHAUS G.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oscillatory Reactions on Single Crystal Surfaces
Authors: IMBIHL R.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Homoleptic Noble Metal Carbonyl Cations
Authors: WEBER L.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electroenzymatic Synthesis
Authors: STECKHAN E.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: X‐Ray Structural Studies of Metal‐Nucleoside and Metal‐Nucleoside Monophosphate Complexes: New Perspectives
Authors: TERRON A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Thermal Stability, and Photocatalytic Activity of Nanocrystalline Gallium Nitride via the Reaction of Ga2O3 and NH4Cl at Low Temperature.
Authors: Zhang Hong , Chen Youjian , Fu Li , Ma Jianhua
Published: August 2010

Nanocrystalline GaN is synthesized from a mixture of Ga2O3 and NH4Cl in the presence of metallic Mg as reductant (autoclave, 650 °C, 8 h).
ChemInform Abstract: Reinterpretation of Three Crystal Structures of Alkali Oxoiodiate(V) — Description of the [I3O8]‐ Anion and the Infinite 2D [I3O‐8]∞ Anion.
Authors: Gautier‐Luneau Isabelle , Suffren Yan , Jamet Helene , Pilme Julien
Published: August 2010

The compounds α‐Cs2I4O11, β‐Cs2I4O11, and Rb2I6O15 (OH)2·H2O are re‐described as (III), (II), and (VI), respectively, showing the presence of the [I3O8]‐ anion.
ChemInform Abstract: New Ternary Boride Carbides RE10B9+xC10‐x (RE: Gd, Tb; x ≈ 0.2): Infinite Boron Carbon Branched Chains.
Authors: Babizhetskyy Volodymyr , Hiebl Kurt , Mattausch Hansjuergen , Simon Arndt
Published: August 2010

The title compounds are prepared by melting stoichiometric mixtures of the elements under Ar for 8 h at 1790 and 1840 K, for the Gd and Tb samples, respectively, followed by annealing in silica tubes at 1270 K for one month.
ChemInform Abstract: A New Example of the Structure Type A2[{Z2R4}X9]: Synthesis and Crystal Structure of Na2[{(ON)Ce4}Cl9].
Authors: Schurz Christian M. , Meyer Monika , Meyer Gerd , Schleid Thomas
Published: August 2010

Single crystals of the new title compound are prepared by reaction of Ce, CeCl3, and NaN3 in a reactive NaCl flux (850 °C, 7 d).
ChemInform Abstract: Synthesis of Er5(BO3)2F9 and Properties of RE5(BO3)2F9 (RE: Er, Yb).
Authors: Haberer Almut , Kaindl Reinhard , Konzett Juergen , Glaum Robert , Huppertz Hubert
Published: August 2010

Er5(BO3)2F9 is obtained from an equimolar mixture of Er2O3, B2O3, and ErF3 (BN crucible, multianvil apparatus, 3 GPa, 800 °C, 20 min).
ChemInform Abstract: [Sn9HgSn9]6‐: An Intermetalloid Zintl Ion with Two Sn9 Connected by Heteroatom.
Authors: Yong Li , Boeddinghaus M. Bele , Faessler Thomas F.
Published: August 2010

The new compound (III) crystallizes in the space group P$\bar 1$ with Z = 2 (single crystal XRD).
ChemInform Abstract: Synthesis, Crystal Structures, and Vibrational Spectra of Novel Azidopalladates of the Alkali Metals Cs2[Pd(N3)4] and Rb2[Pd(N3)4]·2/3H2O.
Authors: Afyon Semih , Hoehn Peter , Somer Mehmet
Published: August 2010

The transparent dark orange title compounds are prepared by slow evaporation of aqueous solutions of K2PdCl4 and CsN3 or RbN3 (25 °C, 12—24 h; caution: the products are highly explosive).
ChemInform Abstract: Synthesis of 1,2‐ and 1,4‐Amino Alcohols from 1,3‐Dienes via Oxazines. Rearrangements of 1,4‐Amino Alcohol Derivatives to Oxazolines.
Authors: Werner Lukas , Hudlicky Jason Reed , Wernerova Martina , Hudlicky Tomas
Published: August 2010

A variety of 1,4‐N‐acetylamino alcohols are prepared from dienes by standard procedures.
ChemInform Abstract: An Effective Procedure for the Synthesis of Acid‐Sensitive Epoxides: Use of 1‐Methylimidazole as the Additive on Methyltrioxorhenium‐Catalyzed Epoxidation of Alkenes with Hydrogen Peroxide.
Authors: Yamazaki Shigekazu
Published: August 2010

A catalytic system combining MeReO3 and 3‐methylpyrazole with 1‐methylimidazole is successfully applied to the epoxidation of various alkenes with hydrogen peroxide.
ChemInform Abstract: Mild, Base‐Free Copper‐Catalyzed N‐Arylations of Heterocycles Using Potassium Aryltrifluoroborates in Water under Air.
Authors: Joubert Nicolas , Basle Emmanuel , Vaultier Michel , Pucheault Mathieu
Published: August 2010

An efficient N‐arylation becomes possible under air using an inexpensive Cu catalyst in water.
ChemInform Abstract: Exploration of Amino‐Functionalized Ionic Liquids as Ligand and Base for Heck Reaction.
Authors: Liu Jie , Liu Hongqiang , Wang Lei
Published: August 2010

The key feature of the method is that the Pd species and ionic liquids are easily recovered and reused six times with constant activity.
ChemInform Abstract: Ionic Liquid: An Efficient and Recyclable Medium for the Synthesis of Octahydroquinazolinone and Biscoumarin Derivatives.
Authors: Khurana Jitender M. , Kumar Sanjay
Published: August 2010

Both Biginelli reaction to octahydroquinazolinones (IV) and condensation to biscoumarin derivatives (VII) are performed in ionic liquids.
ChemInform Abstract: BF3·OEt2: An Efficient Catalyst for Transesterification of β‐Ketoesters.
Authors: Yang Jinhui , Ji Congbin , Zhao Yanmin , Li Yunfeng , Jiang Shizhi , Zhang Zhiwei , Ji Yongqiang , Liu Wanyi
Published: August 2010

Aliphatic, α‐bromo or ‐cyano and α,β‐unsaturated esters do not undergo the transesterification reaction.
ChemInform Abstract: Synthesis of Imides and Amides from Diacetyl‐L‐Tartaric Acid Anhydride.
Authors: Naz Sara , Zaidi Javid H. , Mehmood Tahir , Wali Sher , Ali Muhammad , Taha Muhammad , Khan Khalid M.
Published: August 2010

The product obtained is determined by steric as well as electronic factors.
ChemInform Abstract: Catalytic Synthesis of 3‐Alkoxyacrylic Acid Esters under Neat Conditions.
Authors: Wang Junhua , Wang Honglin , Ren Hongmin
Published: August 2010

Under neat conditions, the presented reaction occurs much more rapidly than in solvent.
ChemInform Abstract: Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N‐Phosphinylimines Employing La(III)‐TFAA Activation.
Authors: Kinoshita Hidenori , Ingham Oscar J. , Ong Winnie W. , Beeler Aaron B. , Porco John A. Jr.
Published: August 2010

N‐Phosphinylimines such as (I) undergo nucleophilic additions such as aza‐Friedel—Crafts reactions, aza‐ene reactions, tandem aza‐Prins/Friedel—Crafts reactions and tandem reactions with 1,3‐dienes to give a series of non‐cyclized and cyclized products or the bis‐indan (XIX).
ChemInform Abstract: Highly Stereoselective Preparation of Tertiary Homoallylic Alcohols with Multiple Stereogenic Centers.
Authors: Takeda Takeshi , Nishimura Takuya , Yatsumonji Yasutaka , Noguchi Keiichi , Tsubouchi Akira
Published: August 2010

A method for the construction of three or four adjacent stereocenters at the tertiary homoallylic alcohols is presented.
ChemInform Abstract: Asymmetric, Organocatalytic, Three‐Step Synthesis of α‐Hydroxy‐(E)‐β,γ‐unsaturated Esters.
Authors: Hess Lindsey C. , Posner Gary H.
Published: August 2010

The method includes preparation of the α‐selenyl aldehydes, Wittig reaction, oxidation and the spontaneous [2,3]‐sigmatropic rearrangement.
ChemInform Abstract: Silica‐Bonded S‐Sulfonic Acid: An Efficient and Recyclable Solid Acid Catalyst for the Three‐Component Synthesis of α‐Amino Nitriles.
Authors: Niknam Khodabakhsh , Saberi Dariush , Sefat Maryam Nouri
Published: August 2010

The one‐pot process affords the synthetically important title compounds within a short time in good to excellent yields.
ChemInform Abstract: Recyclable Gallium as Catalyst Precursor for a Convenient and Solvent‐Free Method for the Intermolecular Addition of Sulfonamides to Alkenes.
Authors: Jaspers Daniel , Kubiak Raphael , Doye Sven
Published: August 2010

GaI3, generated in situ under optimized conditions, is highly efficient for the inter‐ and intramolecular addition of toluenesulfonamides to C=C double bonds.
ChemInform Abstract: An Improved Method for the Synthesis of γ‐DDB.
Authors: Song Chuanjun , Zhao Peng , Hu Zhiqiang , Shi Shuai , Cui Yanmei , Chang Junbiao
Published: August 2010

A highly regioselective bromination of protected gallates and an anhydride‐linker assisted intramolecular Ullmann reaction are the key steps in an improved method for the synthesis of unsymmetrical γ‐dimethylenedioxobiphenyl compound (VII).
ChemInform Abstract: p‐Terphenyl as Unexpected By‐Product in the Synthesis of 2,5‐Diphenylpyrrole from Acetophenone Oxime and Phenylacetylene.
Authors: Petrova O. V. , Mikhaleva A. I. , Sobenina L. N. , Trofimov B. A.
Published: August 2010

Special experiments show that (V) is formed neither from acetophenone oxide nor phenylacetylene but via dimrization of the hydroxymethylation product obtained from educt (I) and solvent DMSO (II).
ChemInform Abstract: Enantioselective Arylations Catalyzed by Carbohydrate‐Based Chiral Amino Alcohols.
Authors: Wouters Ana Dioneia , Trossini Gustavo H. G. , Stefani Helio A. , Luedtke Diogo S.
Published: August 2010

The most efficient ligand is the one derived from D‐xylose bearing a furanoside backbone and a morpholino group.
ChemInform Abstract: Cytotoxicity and Utility of 1‐Indanone in the Synthesis of Some New Heterocycles.
Authors: Hegazi Bahira , Mohamed Hanan Ahmed , Dawood Kamal Mohamed , Abdel‐Rahem Badria Farid
Published: August 2010

A variety of new benzimidazole, 1,2,4‐triazin‐5(2H)‐one, 4‐thiazolidinone, 1,3‐thiazole, hydrazone, imide and bis‐hydrazone derivatives is synthesized using 1‐indanone as starting material.
ChemInform Abstract: Chiral Phosphoric Acid Catalyzed Addition of Dihydropyrans to N‐Acyl Imines: Stereocontrolled Access to Enantioenriched Spirocyclic Oxazoletetrahydropyrans with Three Contiguous Stereocenters.
Authors: Li Guilong , Kaplan Matthew J. , Wojtas Lukasz , Antilla Jon C.
Published: August 2010

The first catalytic asymmetric addition of dihydropyran derivatives to N‐acyl imines proceeds with high yields and enantioselectivities.
ChemInform Abstract: 1‐Aryl‐2‐nitro‐3‐trichloromethylaziridines: Synthesis and Structure.
Authors: Berestovitskaya V. M. , Makarenko S. V. , Bushmarinov I. S. , Lyssenko K. A. , Smirnov A. S. , Stukan E. V.
Published: August 2010

Polyfunctional aziridines (IV) are obtained in a complete stereospecific fashion via addition of aromatic amines (II) to propene (I) and dehydrobromination of the resulting adducts (III).
ChemInform Abstract: Gold‐Catalyzed Intramolecular Oxidative Cross‐Coupling of Nonactivated Arenes.
Authors: Hopkinson Matthew N. , Tessier Arnaud , Salisbury Andrew , Giuffredi Guy T. , Combettes Lorraine E. , Gee Antony D. , Gouverneur Veronique
Published: August 2010

The novel cascade reaction of benzyl‐substituted allenoates affords tricyclic indenofuranone‐type products.
ChemInform Abstract: Polyfunctional Pyrazoles. Part 5. Preparative Synthesis of 1‐Aryl‐4‐formylpyrazole‐3‐carboxylic Acids
Authors: Bratenko M. K. , Barus M. M. , Vovk M. V.
Published: August 2010

based on the reaction of pyruvate N‐aroylhydrazines (IV) with Vilsmeier reagent
ChemInform Abstract: Synthesis and SAR of Derivatives Based on 2‐Biarylethylimidazole as Bombesin Receptor Subtype‐3 (BRS‐3) Agonists for the Treatment of Obesity.
Authors: Liu Jian , et al. et al.
Published: August 2010

Starting from the key intermediate (IV), synthetic pathways to both C—C and C—N linked biaryl derivatives are described.
ChemInform Abstract: Palladium‐Catalyzed Oxime Assisted Intramolecular Dioxygenation of Alkenes with 1 atm of Air as the Sole Oxidant.
Authors: Zhu Ming‐Kui , Zhao Jun‐Feng , Loh Teck‐Peng
Published: August 2010

The incorporation of atmospheric O2 into synthetically useful compounds under extremely mild conditions makes the title methodology environmentally benign, economical, and practical.
ChemInform Abstract: Efficient Solvent‐Free Synthesis of Thiazolidin‐4‐ones from Phenylhydrazine and 2,4‐Dinitrophenylhydrazine.
Authors: Neuenfeldt Patricia D. , Drawanz Bruna B. , Siqueira Geonir M. , Gomes Claudia R. B. , Wardell Solange M. S. V. , Flores Alex F. C. , Cunico Wilson
Published: August 2010

Arylhydrazones (I) react with mercaptoacetic acid to give the desired thiazolidinones.
ChemInform Abstract: Structure‐Based Drug Design of Tricyclic 8H‐Indeno[1,2‐d][1,3]thiazoles as Potent FBPase Inhibitors.
Authors: Tsukada Tomoharu , Takahashi Mizuki , Takemoto Toshiyasu , Kanno Osamu , Yamane Takahiro , Kawamura Sayako , Nishi Takahide
Published: August 2010

A series of new tetracyclic indenothiazoles is designed and synthesized with the aid of structure‐based drug design (14 examples).
ChemInform Abstract: HBF4·OEt2 as a Versatile Reagent for the Hosomi—Sakurai Allylation and Prins Cyclization: One‐Pot Synthesis of Symmetrical 4‐Fluorotetrahydropyrans.
Authors: Yadav J. S. , Reddy B. V. Subba , Anusha B. , Reddy U. V. Subba , Reddy V. V. Bhadra
Published: August 2010

The tandem process affords the target compounds in a diastereoselective manner.
ChemInform Abstract: Synthesis of [5‐(1H‐1,2,3‐Triazol‐4‐yl)‐1,3,4‐oxadiazol‐2‐yl]pyridines.
Authors: Pokhodylo N. T. , Shiika O. Ya. , Matiichuk V. S. , Obushak N. D.
Published: August 2010

via reaction of 1,2,3‐triazolylcarbonyl chlorides (I) and tetrazolyl‐substituted pyridines (II) (22 examples)
ChemInform Abstract: Rhodium(III)‐Catalyzed Isoquinolone Synthesis: The N—O Bond as a Handle for C—N Bond Formation and Catalyst Turnover.
Authors: Guimond Nicolas , Gouliaras Christina , Fagnou Keith
Published: August 2010

A new approach to C—N bond formation starting from benzhydroxamic acids is developed.
ChemInform Abstract: Photoinduced Tandem Reactions of Isoquinoline‐1,3,4‐trione with Alkynes to Build Azapolycycles.
Authors: Yu Haitao , Li Jinbo , Kou Zhuangfei , Du Xuewen , Wei Yi , Fun Hoong‐Kun , Xu Jianhua , Zhang Yan
Published: August 2010

Irradiation of isoquinoline (I) with alkynes allows facile access to various novel aza‐polycycles.
ChemInform Abstract: Novel Methods to Functionalize Thiazolo[4,5‐c]pyridines.
Authors: Girijavallabhan Vinay , Arasappan Ashok , Bennett Frank , Huang Yuhua , Njoroge F. George , MacCoss Malcolm
Published: August 2010

Functionalization of the parent compound (III) as an interesting biological core structure at the 4‐ and 6‐position via the corresponding pyrido N‐oxides [cf.
ChemInform Abstract: Preparation of 6‐Chloropyrazolo[3,4‐b]pyridine‐5‐carbaldehydes by Vilsmeier—Haack Reaction and Its Use in the Synthesis of Heterocyclic Chalcones and Dipyrazolopyridines.
Authors: Quiroga Jairo , Diaz Yurina , Insuasty Braulio , Abonia Rodrigo , Nogueras Manuel , Cobo Justo
Published: August 2010

A synthesis of pharmacologically interesting novel carbaldehydes (III) is described and their utility for the synthesis of title derivatives (V) and (VI) is demonstrated.
ChemInform Abstract: Highly Efficient Three‐Component Synthesis of 1H‐Indazolo[1,2‐b]phthalazinetrione Derivatives Catalyzed by Heteropolyacids.
Authors: Wang Hong‐Juan , Zhang Xiao‐Nan , Zhang Zhan‐Hui
Published: August 2010

The reaction conditions are optimized and a plausible reaction mechanism is proposed.
ChemInform Abstract: Diversity‐Oriented Synthesis of Benzimidazole, Benzoxazole, Benzothiazole and Quinazolin‐4(3H)‐one Libraries via Potassium Persulfate—CuSO4‐Mediated Oxidative Coupling Reactions of Aldehydes in Aqueous Micelles.
Authors: Kumar Atul , Maurya Ram Awatar , Saxena Deepti
Published: August 2010

The diversity‐oriented synthesis of the title heterocycles in aqueous micelles shows the advantages of short reaction times, high yields, high chemoselectivities, low coast, and environmental friendliness.
ChemInform Abstract: Synthesis of Uracil Derivatives and Their Alkylation: An Approach to Peptide Non‐nucleic Acid Monomers.
Authors: Jachak Madhukar N. , Birari Dilip R. , Toche Raghunath B. , Ghagare Maruti G. , Bagul Sandeep M.
Published: August 2010

The introduction of various functionalities at N‐1 position of uracils (II) leads to derivatives of type (IV).
ChemInform Abstract: Synthesis of Some New Nitrogen Bridge‐Head Pyrido[1,2,4]triazepines
Authors: Abdel‐Megid M.
Published: August 2010

via ring closure reactions of 1,6‐diaminopyridine (I) with some interesting 1,3‐dielectrophiles
ChemInform Abstract: Synthesis of Unnatural Selenocystines and β‐Aminodiselenides via Regioselective Ring‐Opening of Sulfamidates Using a Sequential, One‐Pot, Multistep Strategy.
Authors: Baig Nasir Baig Rashid , Chandrakala R. N. , Sudhir V. Sai , Chandrasekaran Srinivasan
Published: August 2010

Formation of peptide derivatives is also described.
ChemInform Abstract: Total Synthesis and Structural Revision of Vannusals A and B: Synthesis of the Originally Assigned Structure of Vannusal B.
Authors: Nicolaou K. C. , Ortiz Adrian , Zhang Hongjun , Dagneau Philippe , Lanver Andreas , Jennings Michael P. , Arseniyadis Stellios , Faraoni Raffaella , Lizos Dimitrios E.
Published: August 2010

Vannusal B (Ia) is prepared and found to be not the natural product.
ChemInform Abstract: Total Synthesis and Structural Revision of Vannusals A and B: Synthesis of the True Structures of Vannusals A and B.
Authors: Nicolaou K. C. , Ortiz Adrian , Zhang Hongjun , Guella Graziano
Published: August 2010

Various synthetic approaches concerning diastereomers of the title compounds lead to the result that the natural substances are represented by structure (Ia)(vannusal B) and (Ib)(vannusal A).
ChemInform Abstract: Two Novel Norsesquiterpene Peroxides from Basidiomycete Steccerinum ochraceum
Authors: Liu Dong‐Ze , Dong Ze‐Jun , Wang Fang , Liu Ji‐Kai
Published: August 2010

steperoxide A (Ia) and (B) (Ib)
ChemInform Abstract: Two New Asymmetric Sesquiterpene Dimers from the Rhizomes of Ligularia muliensis
Authors: Fei Dong‐Qing , Wu Qiu‐Hong , Li Shi‐Gang , Gao Kun
Published: August 2010

isolation, structure determination and cytotoxicity of ligulamulienin A (I) and B (II)
ChemInform Abstract: Amaranzoles B—F, Imidazole‐2‐carboxy Steroids from the Marine Sponge Phorbas amaranthus. C24‐N‐ and C24‐O‐Analogues from a Divergent Oxidative Biosynthesis
Authors: Morinaka Brandon I. , Pawlik Joseph R. , Molinski Tadeusz F.
Published: August 2010

isolation and structures of the new title compounds (I)—(III)
ChemInform Abstract: Bioactive Constituents from Chinese Natural Medicines. Part 36. Four New Acylated Phenylethanoid Oligoglycosides, Kankanosides J1, J2, K1, and K2, from Stems of Cistanche tubulosa.
Authors: Pan Yingni , Morikawa Toshio , Ninomiya Kiyofumi , Imura Katsuya , Yuan Dan , Yoshikawa Masayuki , Muraoka Osamu
Published: August 2010

Isolation and structure elucidation of four new oligoglycosides, epimeric kankanosides J (I) and K (II), resp., are described.
ChemInform Abstract: The Raputindoles: Novel Cyclopentyl Bisindole Alkaloids from Raputia simulans.
Authors: Vougogiannopoulou Konstantina , Fokialakis Nikolas , Aligiannis Nektarios , Cantrell Charles , Skaltsounis Alexios‐Leandros
Published: August 2010

Raputindoles A‐D (I)—(IV) are isolated and structurally characterized.
ChemInform Abstract: A New Flavonoid from Selaginella tamariscina (Beauv.) Spring
Authors: Tan Gui‐Shan , et al. et al.
Published: August 2010

isolation and structure determination of the new flavanoid (I), together with two natural products (II) and (III)
ChemInform Abstract: 7‐Phenylplatensimycin (IIIa) and 11‐Methyl‐7‐phenylplatensimycin (IIIb): More Potent Analogues of Platensimycin
Authors: Jang Ki Po , Kim Chan Hyuk , Na Seong Wook , Jang Dong Seok , Kim Hiyoung , Kang Heonjoong , Lee Eun
Published: August 2010

synthesis of the title compounds (III) utilizing a carbonyl ylide cycloaddition strategy
ChemInform Abstract: Halogenated Analogues of 1′‐Acetoxychavicol Acetate, Rev‐Export Inhibitor from Alpinia galanga, Designed from Mechanism of Action.
Authors: Tamura Satoru , Shiomi Atsushi , Kimura Tominori , Murakami Nobutoshi
Published: August 2010

A quinone methide intermediate is assumed to be essential for exerting the inhibitory activity of 1′‐acetoxychavicol acetate (ACA), the Rev‐export inhibitor from the medicinal plant Alpinia galanga.
ChemInform Abstract: Synthetic Studies on Natural Products. Part 73. Stereoselective Synthesis of Bioactive Natural Spiroacetals Aculeatins A and B.
Authors: Das Biswanath , Krishnaiah Martha , Sudhakar Chithaluri
Published: August 2010

A new and efficient route to spiroacetals aculeatin A (VI) and B (VII) is presented.
ChemInform Abstract: The First F‐Ring Modified Ciguatoxin Analogue Showing Significant Toxicity.
Authors: Ishihara Yuuki , Lee Nayoung , Oshiro Naomasa , Matsuoka Shigeru , Yamashita Shuji , Inoue Masayuki , Hirama Masahiro
Published: August 2010

The total synthesis of a 10‐membered F‐ring analogue of 51‐hydroxyCTX3C is described which constitutes the first example of an F‐ring modified ciguatoxin that exhibits potent cytotoxicity as well as mouse acute toxicity.
ChemInform Abstract: Lignans from Santalum album and Their Cytotoxic Activities
Authors: Matsuo Yukiko , Mimaki Yoshihiro
Published: August 2010

isolation and cytotoxic activities of the new neolignan (I) and four known lignans
ChemInform Abstract: Developing an Anion Host for Lipid A Binding and Antibacterial Activity.
Authors: Henderson Luke C. , Li Jian , Nation Roger L. , Velkov Tony , Pfeffer Frederick M.
Published: August 2010

New structural amphiphiles (I) bind the diphosphate lipid A anion and show potential as lead compounds for the development of novel antibacterial agents.
ChemInform Abstract: Chimeric Microtubule Disruptors.
Authors: Potter Barry V. L. , et al. et al.
Published: August 2010

Integrating pharmacophore elements from 2 series of methoxyestradiol and colchicine, a new class of microtubule disruptors (I) and (II) is formed.
ChemInform Abstract: Bulk Nanocrystalline and Amorphous Magnetic Materials
Authors: Groessinger Roland , Turtelli Reiko Sato
Published: August 2010

Review: 141 refs.
ChemInform Abstract: Mechanism of Generation of Volatile Species by Aqueous Boranes
Authors: D'Ulivo Alessandro
Published: August 2010

Review: 82 refs.
ChemInform Abstract: Theory of Absolute Rates of Gas/Solid Interface Reactions
Authors: Tovbin Yu. K.
Published: August 2010

Review: 153 refs.
ChemInform Abstract: Ferromagnetic Shape Memory Alloy Actuators
Authors: Liang Yuanchang , Taya Minoru
Published: August 2010

Review: 68 refs.
ChemInform Abstract: Crystalline Oxides on Silicon
Authors: Reiner James W. , Kolpak Alexie M. , Segal Yaron , Garrity Kevin F. , Ismail‐Beigi Sohrab , Ahn Charles H. , Walker Fred J.
Published: August 2010

Review: 145 refs.
ChemInform Abstract: Recent Progress of New Catalytic Synthetic Methods for Nitrogen Heterocycles Based on Hydrogen Transfer Reactions
Authors: Yamaguchi Ryohei , Fujita Ken‐ichi , Zhu Mingwen
Published: August 2010

Review: 62 refs.
ChemInform Abstract: Steroids: Partial Synthesis in Medicinal Chemistry
Authors: Hanson James R.
Published: August 2010

Review: 285 refs.
ChemInform Abstract: Chemical Synthesis of Homogeneous Glycopeptides and Glycoproteins
Authors: Kajihara Yasuhiro , Yamamoto Naoki , Okamoto Ryo , Hirano Kiriko , Murase Takefumi
Published: August 2010

Review: 101 refs.
ChemInform Abstract: P‐Ligands Bound to Chiral Biomolecules
Authors: Malan Christophe , Ward Thomas R.
Published: August 2010

Review: 63 refs.
ChemInform Abstract: Recent Progress in Synthesis and Applications of Fluorinated Carbohydrates
Authors: Cheng Yuan , Guo Ai‐Ling , Guo Dian‐Shun
Published: August 2010

Review: 96 refs.
ChemInform Abstract: Controlled Preparation of Heterogeneous Catalysts for Chemo‐ and Enantioselective Hydrogenation Reactions
Authors: Ferretti Osmar Alberto , Casella Monica Laura
Published: August 2010

Review: 135 refs.
ChemInform Abstract: Catalytic Properties of Single Site Catalysts Prepared via Surface Organometallic Chemistry on Oxides and on Metals
Authors: Basset Jean‐Marie , Baudouin Anne , Bayard Francois , Candy Jean‐Pierre , Coperet Christophe , De Mallmann Aimery , Godard Gregory , Kuntz Emile , Lefebvre Frederic , Lucas Christine , et al. et al.
Published: August 2010

Review: 118 refs.
ChemInform Abstract: And If Everything Was as Easy as a “Click”: Cu(I)‐Catalyzed 1,3‐Dipolar Cycloaddition Between Terminal Alkynes and Azides
Authors: Lucas Romain , Zerrouki Rachida , Krausz Pierre
Published: August 2010

Review: 27 refs.
ChemInform Abstract: Ring‐Closing Metathesis of Dienes and Enynes
Authors: Mori Miwako
Published: August 2010

Review: 198 refs.
ChemInform Abstract: Transition Metal Catalyzed Cyclization Reactions of Functionalized Alkenes, Alkynes, and Allenes
Authors: Patil Nitin T. , Yamamoto Yoshinori
Published: August 2010

Review: 247 refs.
ChemInform Abstract: Cyclic Carbometallation of Alkenes, Arenes, Alkynes and Allenes
Authors: Grigg Ron , Inman Martyn
Published: August 2010

Review: 211 refs.
ChemInform Abstract: Intramolecular 1,2‐Addition and 1,4‐Addition Reactions
Authors: Lu Xiyan , Han Xiuling
Published: August 2010

Review: 263 refs.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition
Authors: Hashimoto Takuya , Maruoka Keiji
Published: August 2010

Review: 304 refs.
ChemInform Abstract: Photocyclization Reactions
Authors: Griesbeck Axel G.
Published: August 2010

Review: 177 refs.
ChemInform Abstract: Free Radical Cyclization Reactions
Authors: Zimmerman Joke , Halloway Amanda , Sibi Mukund P.
Published: August 2010

Review: 204 refs.
ChemInform Abstract: Recent Advances in Retrometabolic Drug Design (RMDD) and Development
Authors: Bodor N. , Buchwald P.
Published: August 2010

Review: 64 refs.
ChemInform Abstract: The Chemistry and Biology of Cytochalasans
Authors: Scherlach Kirstin , Boettger Daniela , Remme Nicole , Hertweck Christian
Published: August 2010

Review: 159 refs.
ChemInform Abstract: Antitubercular Potential of Plants: A Brief Account of Some Important Molecules
Authors: Negi Arvind S. , Kumar Jonnala K. , Luqman Suaib , Saikia Dharmendra , Khanuja Suman P. S.
Published: August 2010

Review: 102 refs.
ChemInform Abstract: Structure and Stability of the Heteroannulated [8‐10]Circulenes: A Quantum‐Chemical Study
Authors: Gribanova Tatyana N. , Zefirov Nikolay S. , Minkin Vladimir I.
Published: August 2010

Review: 41 refs.
ChemInform Abstract: Chemomechanics with Molecular Force Probes
Authors: Huang Zhen , Boulatov Roman
Published: August 2010

Review: 56 refs.
First molecules, biological chirality, origin(s) of life
Authors: Caglioti Luciano , Micskei Károly , Pályi Gyula
Published: August 2010

Origin(s) of biological chirality appear(s) to be intimately connected to origin(s) of life. Prebiotic evolution toward these important turning points can be traced back to single chiral molecules. These can be small (monomeric) units as amino acids or monosaccharides or oligomers as oligo‐RNA type molecules. Earlier speculations about these two kinds of entries to biological chirality are critically reviewed. Chirality, 2011. © 2010 Wiley‐Liss, Inc.
Estimating chromatographic enantioselectivity (α) from gradient enantioselective chromatography data
Authors: Gong Xiaoyi , Craven Tim , Schafer Wes , Pirzada Zainab , Biba Mirlinda , Welch Christopher J.
Published: August 2010

Calculation of chromatographic enantioselectivity (α) is critically important in enantioselective chromatographic method development studies. The fact that α can only be calculated from isocratic elution conditions, whereas gradient elution conditions are predominantly used in method development screening, presents some problems for the use of α as a scoring indicator for automated, intelligent enantioselective chromatography method development systems. In this study, an empirical algorithm was developed to estimate α at isocratic conditions based upon information collected from a gradient elution. The algorithm was validated for SFC applications and has been shown to accurately predict enantioselectivity for a wide variety of racemic test analytes eluted on different chiral column and mobile phase conditions. Chirality, 2011. © 2010 Wiley‐Liss, Inc.
Three‐dimensional direct simulation of a droplet impacting onto a solid sphere with low‐impact energy
Authors: Yan‐Peng Li , Huan‐Ran Wang
Published: August 2010

In this paper, a numerical model is developed for direct simulation of droplet impinging onto a spherical surface on a fixed Eulerian mesh. The model couples the level‐set method and the interfacial cell immersed boundary method to the single‐fluid formulation of the Navier–Stokes equations which are solved by a finite‐volume projection technique. Moving contact lines are modelled here with a simple static contact angle model. The model is shown to converge, and to agree with previous work in the literature. The model is then applied to investigate the impact behaviour of a droplet onto solid sphere of different diameters at low Weber number and low Reynolds number. The simulation results show that the droplet used in present study seems to deposit on different spherical surfaces through oscillating. The simulated results also suggest that the impacted‐sphere size has a significant effect on the impact dynamics of the droplet. A local breakage phenomenon may be found in the centre of the droplet collision with a smaller sphere during the first recoiling stage. A regime map is then established to provide quantitative analysis for the breakage mode of the current impacting process.
Sorafenib in patients with metastatic renal cell carcinoma refractory to either sunitinib or bevacizumab
Authors: Garcia Jorge A. , Hutson Thomas E. , Elson Paul , Cowey C. Lance , Gilligan Timothy , Nemec Cheryl , Dreicer Robert , Bukowski Ronald M. , Rini Brian I.
Published: August 2010

BACKGROUND:

Bevacizumab and sunitinib are standard initial therapy in metastatic renal cell carcinoma (mRCC). Despite common use, the safety and activity of sorafenib in bevacizumab‐ or sunitinib‐refractory mRCC have not been prospectively investigated.

METHODS:

Metastatic RCC patients with Response Evaluation Criteria in Solid Tumors (RECIST)‐defined disease progression (PD) after treatment with either bevacizumab or sunitinib received twice daily 400 mg of sorafenib in a multicenter, prospective phase 2 study. Dose escalation was permitted in the absence of significant toxicity. The primary endpoint was tumor burden reduction rate, defined as the proportion of patients with ≥5% reduction in the sum of RECIST‐defined target lesions without other PD. Secondary endpoints included progression‐free survival (PFS), duration of response, overall survival, and safety. A 2‐stage accrual design was used to test the alternative hypothesis that the tumor burden reduction rate was >20% versus <5%.

RESULTS:

Forty‐eight patients were enrolled. The tumor burden reduction rate was 30% (95% confidence interval [CI], 17%‐45%). One unconfirmed objective partial response was observed. The median PFS was 4.4 months (95% CI, 3.6‐5.9). There was no association of PFS and tumor shrinkage with response to prior therapy. Most treatment‐related adverse events were of mild‐to‐moderate intensity, and included fatigue, hypertension, diarrhea, and palmoplantar erythrodysesthesia (PPE). Patients previously treated with bevacizumab tended to develop more PPE (P = .03) and mucositis (P = .06), whereas sunitinib‐treated patients tended to develop more skin rash (P = .06).

CONCLUSIONS:

Administration of sorafenib is safe and feasible in patients with mRCC refractory to either bevacizumab or sunitinib. Modest clinical activity was observed supporting current practice patterns of sequential vascular endothelial growth factor‐targeted therapy in mRCC. Cancer 2010. © 2010 American Cancer Society.
Endoscopic esophageal tumor length
Authors: Gaur Puja , Sepesi Boris , Hofstetter Wayne L. , Correa Arlene M. , Bhutani Manoop S. , Watson Thomas J. , Swisher Stephen G. ,   Members of the M. D. Anderson Esophageal Cancer Group and the University of Rochester School of Medicine and Dentistry Foregut Group
Published: August 2010

BACKGROUND:

Pathologic esophageal tumor length (pL) is an independent predictor of long‐term survival. However, whether patients with longer (high‐risk) tumors can be identified by endoscopy before surgery has not been established. The objective of the current study was to determine the value of endoscopically measured tumor length (cL) in predicting overall survival in patients with esophageal adenocarcinoma.

METHODS:

All patients with esophageal adenocarcinoma who had undergone resection without neoadjuvant therapy and who had documented preoperative endoscopy findings were identified retrospectively by using prospectively collected databases at 2 institutions: The University of Texas M. D. Anderson Cancer Center (n = 164; training set) and University of Rochester Medical Center (n = 109; validation set). Esophageal tumors were assessed preoperatively by endoscopy for cL, depth (cT), and lymph node involvement (cN). Univariate and multivariate analyses of cL and other standard prognostic factors were performed.

RESULTS:

In the training set, cL was correlated directly with pL (Pearson correlation [r] = 0.683;P< .001). Regression tree analyses suggested an optimum cutoff point of cL >2 cm to identify patients with decreased long‐term survival (5‐year survival rate: cL >2 cm, 29%; cL ≤2 cm, 78%;P< .001). Multivariate Cox regression analysis demonstrated that cL >2 cm was an independent risk factor for long‐term survival (hazard ratio, 2.3; 95% confidence interval, 1.1‐4.4;P= .02) even after controlling for age, cT, and cN. Validation with the validation dataset confirmed that cL was correlated directly with pL (r= 0.657;P< .001) and predicted long‐term survival using a cL cutoff point of >2 cm (hazard ratio, 2.8; 95% confidence interval, 1.4‐5.8;P= .004; univariate analysis).

CONCLUSIONS:

Endoscopic esophageal tumor length was identified as an independent predictor of long‐term survival and may help to identify high‐risk patients before they receive cancer‐directed therapy. Cancer 2011. © 2010 American Cancer Society.