bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute binocular diplopia: peripheral or central?
Authors: Kremmyda Olympia , Frenzel Claudia , Hüfner Katharina , Goldschagg Nicolina , Brem Christian , Linn Jennifer , Strupp Michael
Published: August 2020

Objectives

Acute diplopia is a diagnostic challenge for clinicians, in particular in the emergency department. The most common cause of acute diplopia are ocular motor nerve palsies (OMP). In this prospective study, we focused on identifying the most crucial signs and symptoms for differentiating between peripheral and central OMP.

Methods

We prospectively evaluated 56 non-consecutive patients who presented at our emergency department with acute binocular diplopia (≤ 10 days). The patient history was taken using a standardized questionnaire and patients underwent a neurological, neuro-ophthalmological and neuro-otological examination, including measurement of the subjective visual vertical (SVV), Harms tangent screen test, and cranial MRI.

Results

Forty-six out of 56 patients were diagnosed with an ocular motor cranial nerve palsy (OMP), 21 of peripheral and 23 of central origin; in two patients, the etiology remained unknown. The following features were different in peripheral and central OMP: (1) the presence of vertigo/dizziness was more frequent in central (43.5%) than in peripheral (9.5%) OMP. (2) Central ocular motor signs, such as saccadic smooth pursuit, additional internuclear ophthalmoplegia, skew deviation, and saccade palsies, were also found more frequently in the central than in the peripheral group (86.7% vs. 33.3%). (3) Further, a pathological SVV deviation by monocular testing of the non-affected eye was also more common in central (77.3%) than in peripheral OMP (38.9%). The presence of all three factors has a positive predictive value of 100% (CI 50–100%) for the presence of a central lesion.

Conclusions

In acute diplopia due to central OMP, the most important accompanying symptom is vertigo/dizziness, and the most important clinical signs are central ocular motor disorders (which require examination of the non-paretic eye) and an SVV deviation in the non-paretic eye.
Review of preventative HIV vaccine clinical
trials in South Africa
Authors: Laher Fatima , Bekker Linda-Gail , Garrett Nigel , Lazarus Erica M. , Gray Glenda E.
Published: August 2020

New HIV infections continue relentlessly in southern Africa, demonstrating
the need for a vaccine to prevent HIV subtype C. In South Africa, the country with the
highest number of new infections annually, HIV vaccine research has been ongoing since
2003 with collaborative public-private-philanthropic partnerships. So far, 21 clinical
trials have been conducted in South Africa, investigating seven viral vectors, three DNA
plasmids, four envelope proteins, five adjuvants and three monoclonal antibodies. Active
vaccine candidates have spanned subtypes A, B, C, E and multi-subtype mosaic sequences.
All were well tolerated. Four concepts were investigated for efficacy: rAd5-gag/pol/nef
showed increased HIV acquisition in males, subtype C ALVAC/gp120/MF59 showed no
preventative efficacy, and the trials for the VRC01 monoclonal antibody and
Ad26.Mos4.HIV/subtype C gp140/ aluminum phosphate are ongoing. Future trials are planned
with DNA/viral vector plus protein combinations in concert with pre-exposure
prophylaxis, and sequential immunization studies with transmitted/founder HIV envelope
to induce broadly neutralizing antibodies. Finally, passive immunization trials are
underway to build on the experience with VRC01, including single and combination
antibody trials with an antibody derived from a subtype-C-infected South African donor.
Future consideration should be given to the evaluation of novel strategies, for example,
inactivated-whole-virus vaccines.
Management of post-traumatic craniovertebral junction dislocation: A PRISMA-compliant systematic review and meta-analysis of casereports
Authors: Klepinowski Tomasz , Limanówka Bartosz , Sagan Leszek
Published: August 2020

Although historically considered fatal, with the advent of improved pre-hospital care, traumatic dislocation of the craniovertebral junction (CVJ) has been increasing in prevalence in neurosurgical centers. As more survivors are reported each year, a timely review with meta-analysis of their management seems necessary. PRISMA checklist was followed step by step. PubMed and Web of Science databases were searched using words “craniovertebral junction dislocation” and their corresponding synonyms. Study eligibility criteria included research studies from 2015 onwards that delineated adult and pediatric patients with confirmed post-traumatic atlantooccipital dislocation (AOD) or atlantoaxial dislocation (AAD) who survived until proper treatment. Of 1475 initial records, 46 articles met eligibility criteria with a total of 141 patients with traumatic CVJ dislocation. Of the patients, 90 were male (63.8%). Mean age of the cohort was 33.3 years (range 1–99 years). Trauma that most often led to this injury was road traffic accident (70.9%) followed by falls (24.6%). The majority of authors support posterior instrumentation of C1-C2 (45.2%) especially by means of Goel-Harms method. At mean follow-up of 15.4 months (range 0.5–60 months), 27.2% of treated patients remained neurologically intact. Of initially symptomatic, 59% improved, 37% were stable, and 4% deteriorated. Instrumenting the occiput in cases of pure AAD was associated with lower chance of neurological improvement in chi-square test (p = 0.0013) as well as in multiple linear regression (β = − 0.3; p = 0.023). The Goel-Harms C1-C2 fusion is currently the most frequently employed treatment. Many survivors remain with no deficits or improve, rarely deteriorate. Involving the occiput in stabilization in cases of AAD without AOD might be related with worse neurological prognosis.
Group Theoretical Derivation of Consistent Free Particle Theories
Authors: Nisticò Giuseppe
Published: August 2020

The difficulties of relativistic particle theories formulated by means of canonical quantization, such as those of Klein–Gordon and Dirac, ultimately led theoretical physicists to turn to quantum field theory to model elementary particle physics. In order to overcome these difficulties, the theories of the present approach are developed deductively from the physical principles that specify the system, without making use of canonical quantization. For a free particle these starting assumptions are invariance of the theory and covariance of position with respect to Poincaré transformations. In pursuing the approach, the effectiveness of group theoretical methods is exploited. The coherent development of our program has shown that robust classes of representations of the Poincaré group, discarded by the known particle theories, can in fact be taken as bases for perfectly consistent theories. For massive spin zero particles, six inequivalent theories have been determined, two of which do not correspond to any of the current ones; all of these theories overcome the difficulties of Klein–Gordon one. The present lack of the explicit transformation properties of position with respect to boosts prevents the complete determination of non zero spin particle theories. In the past a particular form of these transformation properties was adopted by Jordan and Mukunda. We check its consistency within the present approach and find that for spin $$\frac{1}{2}$$

1
2

particles there is only one consistent theory, which is unitarily related to Dirac’s; yet, once again, it requires classes of irreducible representations previously discarded.
An adaptive large neighborhood search heuristic for the planar storage location assignment problem: application to stowage planning for Roll-on Roll-off ships
Authors: Hansen Jone R. , Fagerholt Kjetil , Stålhane Magnus , Rakke Jørgen G.
Published: August 2020

This paper considers a generalized version of the planar storage location problem arising in the stowage planning for Roll-on/Roll-off ships. A ship is set to sail along a predefined voyage where given cargoes are to be transported between different port pairs along the voyage. We aim at determining the optimal stowage plan for the vehicles stored on a deck of the ship so that the time spent moving vehicles to enable loading or unloading of other vehicles (shifting), is minimized. We propose a novel mixed integer programming model for the problem, considering both the stowage and shifting aspect of the problem. An adaptive large neighborhood search (ALNS) heuristic with several new destroy and repair operators is developed. We further show how the shifting cost can be effectively evaluated using Dijkstra’s algorithm by transforming the stowage plan into a network graph. The computational results show that the ALNS heuristic provides high quality solutions to realistic test instances.
Rheum rhaponticum and Rheum rhabarbarum: a review of phytochemistry, biological activities and therapeutic potential
Authors: Kolodziejczyk-Czepas Joanna , Liudvytska Oleksandra
Published: August 2020

The Rheum genus (Polygonaceae) covers about 60 species of rhubarbs, including specimens with a long ethnomedicinal history in Asia, Europe and other regions of the world. The work reviews available literature (until March, 2020) on phytochemical profile, ethnomedicinal recommendations, biological activities, pharmacological uses and future prospects for therapeutic applications of Rheum rhabarbarum L. (garden rhubarb) and Rheum rhaponticum L. (rhapontic rhubarb). Although the above species are well-known vegetables, scientific interest in these plants is a relatively new issue; most of evidence of their biological activities and therapeutic potential derives from the last 15 years. Rhubarbs contain numerous bioactive substances, belonging to diverse groups of phytochemicals, e.g. stilbenes, anthraquinones and flavonoids. The registered special extract of R. rhaponticum (ERr731®) is administered to alleviate the menopause-related complaints. Furthermore, both ethnomedicinal surveys and recent studies on bioactive substances from rhubarbs indicate that these plants may have significantly broader range of beneficial effects such as antioxidant, anti-inflammatory, antimicrobial and cardioprotective activities.
Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group
Authors: Olsen Alexander , Babikian Talin , Bigler Erin D. , Caeyenberghs Karen , Conde Virginia , Dams-O’Connor Kristen , Dobryakova Ekaterina , Genova Helen , Grafman Jordan , Håberg Asta K. , Heggland Ingrid , Hellstrøm Torgeir , Hodges Cooper B. , Irimia Andrei , Jha Ruchira M. , Johnson Paula K. , Koliatsos Vassilis E. , Levin Harvey , Li Lucia M. , Lindsey Hannah M. , Livny Abigail , Løvstad Marianne , Medaglia John , Menon David K. , Mondello Stefania , Monti Martin M. , Newcombe Virginia F.J. , Petroni Agustin , Ponsford Jennie , Sharp David , Spitz Gershon , Westlye Lars T. , Thompson Paul M. , Dennis Emily L. , Tate David F. , Wilde Elisabeth A. , Hillary Frank G.
Published: August 2020

The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group’s short-term, intermediate, and long-term goals.
Hybrid compliance compensation for path accuracy enhancement in robot machining
Authors: Hähn Felix , Weigold Matthias
Published: August 2020

Robot machining processes with high material removal rates lack of high path accuracy mainly due to the low stiffness of industrial robots. The low stiffness leads to process forces caused deviations of the tool center point (TCP) from the planned position of more than 1 mm in industrial applications. To enhance the path accuracy a novel hybrid compliance compensation is developed. It combines a force sensor and model based online compensation with forces of an offline simulation to instantly react to predictable high force changes e.g. at a milling cutter exit from the work piece. The method is applied to a KUKA KR 300 robot. A compliance model based on a forward kinematic with virtual joints is implemented on an external controller. Cartesian or axis specific compensation values are calculated and transferred to the robot via a control circuit. A compliance measurement method is developed and a force torque sensor is mounted to the flange of the robot. The system is validated in with Cartesian and axis specific compensation values as well as with and without pilot control.
Smooth estimation of size distributions in an oriented cylinder model
Authors: Jongbloed Geurt , McGarrity Kimberly S. , Sietsma Jilt
Published: August 2020

Kernel estimators are proposed for estimating the cumulative distribution functions and the probability density functions of several quantities of interest in a stereological oriented cylinder model. This oriented cylinder model was developed to represent anisotropic microstructural features in materials. The asymptotic properties of these estimators are studied, and the estimators are applied to two banded dual phase steel microstructures. The estimation method is quite general and can also be applied to distributions of other univariate quantities of interest.
Clinical characteristics and treatment of delirium in palliative care settings
Authors: Portela Millinger Filipe , Fellinger Matthäus
Published: August 2020

Delirium is commonly seen in palliative care. It usually develops over a short period of time and is characterized by a disturbance of attention and awareness. As delirium is associated with increased mortality, prevention and early identification of this severe neurocognitive disorder is of high clinical relevance. This paper provides a brief overview of risk factors, preventive measures, current screening and diagnostic procedures, as well as nonpharmacological and pharmacological treatment options of delirium in the palliative care setting.
Enabling trade across borders and food security in Africa
Authors: Bonuedi Isaac , Kamasa Kofi , Opoku Eric Evans Osei
Published: August 2020

Widespread food insecurity remains a daunting challenge in Africa, despite significant gains in global efforts to eliminate hunger over the last three decades. This paper examines the effects of easing trade across borders – through reductions in documents, time, and costs to export and import – on food security outcomes in Africa. To control for endogeneity, this paper employs the first-difference instrumental variable estimator based on panel data covering 45 African countries over the period 2006–2015. The results reveal that poor trade facilitation constitutes a significant driver of food insecurity in Africa. In particular, ineffective trade facilitation is associated with significant increments in the prevalence of undernourishment and depth of food deficit, as well as reductions in dietary energy supply adequacy and access to sanitation facilities. The results show that food availability and food access are significantly hampered by higher documentation requirements and lengthier export and import times. The results suggest that reductions in delays from documentary and border compliance promise to be the most effective trade facilitation reforms to enhance food security in Africa.
Water quality assessment using NSFWQI, OIP and multivariate techniques of Ganga River system, Uttarakhand, India
Authors: Matta Gagan , Nayak Anjali , Kumar Avinash , Kumar Pawan
Published: August 2020

Ganga River water is very much stressed with the rapidly increasing population, climate change and water pollution that increase domestic, agricultural and industrial needs. This study assesses the surface water quality of the River Ganga in India, using NSFWQI, OIP and multivariate techniques. During the current study, water samples from Ganga River were collected for the assessment of 19 physico-chemical determinants from 20 sampling locations. Water quality indices (WQIs) is used to classify the overall impact of different variables of water. Multivariate techniques were utilized to assess the water conditions for productive management of fresh water quality. The WQI results showed that surface water quality varied at the selected sampling sites among medium and good categories. The PCA generates the 6 principle components which highly contributes (80.3%) in influencing the hydro-chemistry of river water. Agricultural waste runoff, untreated effluents and many other anthropogenic activities were identified as main contributor in decreasing the water quality of the River Ganga. To maintain and protect this fresh water resources against contamination, the usage of stringent policies and rules are expected to preserve fresh water resources for people in the future.
Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis
Authors: Liang Xiaojuan , Tao Cong , Pan Jianfei , Zhang Lilan , Liu Lulu , Zhao Ying , Fan Yiping , Cao Chunwei , Liu Jiali , Zhang Jin , Lam Sin Man , Shui Guanghou , Jin Wanzhu , Li Wei , Zhao Jianguo , Li Kui , Wang Yanfang
Published: August 2020

RNF20, an E3 ligase critical for monoubiquitination of histone H2B at lysine 120 (H2Bub), has been implicated in the regulation of various cellar processes; however, its physiological roles in adipocytes remain poorly characterized. Here, we report that the adipocyte-specific knockout of Rnf20 (ASKO) in mice led to progressive fat loss, organomegaly and hyperinsulinemia. Despite signs of hyperinsulinemia, normal insulin sensitivity and improved glucose tolerance were observed in the young and aged CD-fed ASKO mice. In addition, high-fat diet-fed ASKO mice developed severe liver steatosis. Moreover, we observed that the ASKO mice were extremely sensitive to a cold environment due to decreased expression levels of brown adipose tissue (BAT) selective genes, including uncoupling protein 1 (Ucp1), and impaired mitochondrial functions. Significantly decreased levels of peroxisome proliferator-activated receptor gamma (Pparγ) were observed in the gonadal white adipose tissues (gWAT) from the ASKO mice, suggesting that Rnf20 regulates adipogenesis, at least in part, through Pparγ. Rosiglitazone-treated ASKO mice exhibited increased fat mass compared to that of the non-treated ASKO mice. Collectively, our results illustrate the critical role of RNF20 in control of white and brown adipose tissue development and physiological function.
Enhanced Pseudo-Capacitive Contributions to High-Performance Sodium Storage in TiO2/C Nanofibers via Double Effects of Sulfur Modification
Authors: Zhang Yan , Huang Yuanye , Srot Vesna , van Aken Peter A. , Maier Joachim , Yu Yan
Published: August 2020

Pseudo-capacitive mechanisms can provide higher energy densities than electrical double-layer capacitors while being faster than bulk storage mechanisms. Usually, they suffer from low intrinsic electronic and ion conductivities of the active materials. Here, taking advantage of the combination of TiS2 decoration, sulfur doping, and a nanometer-sized structure, as-spun TiO2/C nanofiber composites are developed that enable rapid transport of sodium ions and electrons, and exhibit enhanced pseudo-capacitively dominated capacities. At a scan rate of 0.5 mV s−1, a high pseudo-capacitive contribution (76% of the total storage) is obtained for the S-doped TiS2/TiO2/C electrode (termed as TiS2/S-TiO2/C). Such enhanced pseudo-capacitive activity allows rapid chemical kinetics and significantly improves the high-rate sodium storage performance of TiO2. The TiS2/S-TiO2/C composite electrode delivers a high capacity of 114 mAh g−1 at a current density of 5000 mA g−1. The capacity maintains at high level (161 mAh g−1) even after 1500 cycles and is still characterized by 58 mAh g−1 at the extreme condition of 10,000 mA g−1 after 10,000 cycles.
The Development of Aerobic and Anaerobic Fitness with Reference to Youth Athletes
Authors: Armstrong Neil , Welsman Jo
Published: August 2020

Purpose

To challenge current conventions in paediatric sport science and use data from recent longitudinal studies to elucidate the development of aerobic and anaerobic fitness, with reference to youth athletes.

Methods

(1) To critically review the traditional practice of ratio scaling physiological variables with body mass and, (2) to use multiplicative allometric models of longitudinal data, founded on 1053 (550 from boys) determinations of 10–17-year-olds’ peak oxygen uptake ($$ {{\text{V}}\text{O}}_{2} $$

VO

2

) and 763 (405 from boys) determinations of 11–17-year-olds’ peak power output (PP) and mean power output (MP), to investigate the development of aerobic and anaerobic fitness in youth.

Results

The statistical assumptions underpinning ratio scaling of physiological variables in youth are seldom met. Multiplicative allometric modelling of longitudinal data has demonstrated that fat free mass (FFM) acting as a surrogate for active muscle mass, is the most powerful morphological influence on PP, MP, and peak $$ {{\text{V}}\text{O}}_{2} $$

VO

2

. With FFM appropriately controlled for, age effects remain significant but additional, independent effects of maturity status on anaerobic and aerobic fitness are negated.

Conclusions

Ratio scaling of physiological variables with body mass is fallacious, confounds interpretation of the development of anaerobic and aerobic fitness, and misleads fitness comparisons within and across youth sports. Rigorous evaluation of the development of anaerobic and aerobic fitness in youth requires longitudinal analyses of sex-specific, concurrent changes in age- and maturation-driven morphological covariates. Age and maturation-driven changes in FFM are essential considerations when evaluating the physiological development of youth athletes.
C1,α-estimates for the near field refractor
Authors: Gutiérrez Cristian E. , Tournier Federico
Published: August 2020

We establish local

C^{1,\alpha }

estimates for one source near field refractors under structural assumptions on the target, and with no assumptions on the smoothness of the densities.
Making behavioral science integral to climate science and action
Authors: FISCHHOFF BARUCH
Published: August 2020

The behavioral sciences were there at the beginning of the systematic study of climate change. However, in the ensuing quarter century, they largely faded from view, during which time public discourse and policy evolved without them. That disengagement and the recent reengagement suggest lessons for the future role of the behavioral sciences in climate science and policy. Looking forward, the greatest promise lies in projects that make behavioral science integral to climate science by: (1) translating behavioral results into the quantitative estimates that climate analyses need; (2) making climate research more relevant to climate-related decisions; and (3) treating the analytical process as a behavioral enterprise, potentially subject to imperfection and improvement. Such collaborations could afford the behavioral sciences more central roles in setting climate-related policies, as well as implementing them. They require, and may motivate, changes in academic priorities.
Echoes of the Past: Women, Memories and Disc-on-Bow Brooches in Vendel- and Viking-period Scandinavia
Authors: Glørstad Zanette T. , Røstad Ingunn M.
Published: August 2020

This article examines the development, handling, and depositions of disc-on-bow brooches from the sixth to tenth centuriesadin the Vendel and Viking periods in Norway and mainland Sweden. A revised typological framework is presented, and the context of these brooches explored. The authors discuss their preservation, re-use, fragmentation, and ritual meaning within ongoing social negotiations and internal conflicts from the late Vendel period into the Viking Age. References to the past in Viking-Age society and the significance of women for maintaining narratives of the past are considered, as are levels of access, control, and definition of narratives of the past in times of social redefinition.
Tracing the modes of China's revisionism in the Indo-Pacific: a comparison with pre-1941 Shōwa Japan
Authors: Natalizia Gabriele , Termine Lorenzo
Published: August 2020

The People's Republic of China (PRC) has irrefutably reached ‘great power’ status. As a consequence, most studies argue that it has adopted a revisionist posture towards the US-led international order. However, this image tells us little about Beijing's revisionist strategy, particularly whether it is revolutionary or incremental and what this implies in terms of actual policies. The current article posits that the PRC is behaving as an incremental revisionist and aims at tracing its modes. To verify this hypothesis, the analysis focuses on Beijing's policies towards its regional security order. In this light, it diachronically compares post-Cold War China (1989–2019) with the paradigmatic case of a revolutionary revisionist in the Indo-Pacific region: Shōwa Japan in the Interwar period (1926–1941). The findings offer a helpful contribution to the literature, providing the foundation for a more nuanced theoretical definition of incremental revisionism.
Editorial
Authors: Hamant Olivier
Published: August 2020

Like many scientific communities, plant science has moved to a new era with the rise of quantitative approaches. This is not merely about high-resolution quantification methods or the generation of massive datasets through omics; the quantitative revolution is much deeper because it unfolds the rich complexity behind plant life.
Effects of maternal supplementation with fully oxidised β-carotene on the reproductive performance and immune response of sows, as well as the growth performance of nursing piglets
Authors: Chen Jun , Chen Jiaming , Zhang Yinzhi , Lv Yantao , Qiao Hanzhen , Tian Min , Cheng Lin , Chen Fang , Zhang Shihai , Guan Wutai
Published: August 2020

The present study was conducted to evaluate the impact of dietary fully oxidised β-carotene (OxBC, C40H60O15) supplementation during the perinatal period on immune status and productivity in a sow model. At day 85 of pregnancy, 150 sows were allocated to one of three dietary treatments with fifty sows per treatment. The three experimental diets were supplemented with 0, 4 or 8 mg/kg OxBC in the basal diet. The feeding trial was conducted from gestation day 85 until day 21 of lactation. Dietary OxBC supplementation greatly enhanced colostrum IgM, IgA and IgG levels, and the IgM and IgG content of 14-d milk. Dietary OxBC supplementation decreased the TNF-α and IL-8 levels in colostrum, as well as the TNF-α and IL-18 levels in 14-d milk. There was also a tendency towards an increase in the soluble CD14 level in 14-d milk. Although dietary treatments did not affect average daily feed intake nor backfat thickness loss during lactation, dietary OxBC supplementation tended to enhance litter weight and individual piglet weight at weaning. There was a trend towards increased lactose concentration in 14-d milk with increasing dietary OxBC. It is concluded that dietary supplementation with OxBC during the perinatal period enhances the lactose concentration of sow milk and the immune status of sows, which is reflected by improved cytokine status and immunoglobulin concentrations in colostrum and milk, and thus tending to increase litter weight and individual piglet weight at weaning. The results also provide a scientific nutritional reference for perinatal mothers due to the biological similarity between pigs and humans.
Consumption of ultra-processed foods and health status: a systematic review and meta-analysis
Authors: Pagliai G. , Dinu M. , Madarena M. P. , Bonaccio M. , Iacoviello L. , Sofi F.
Published: August 2020

Increasing evidence suggests that high consumption of ultra-processed foods (UPF) is associated with an increase in non-communicable diseases, overweight and obesity. The present study systematically reviewed all observational studies that investigated the association between UPF consumption and health status. A comprehensive search of MEDLINE, Embase, Scopus, Web of Science and Google Scholar was conducted, and reference lists of included articles were checked. Only cross-sectional and prospective cohort studies were included. At the end of the selection process, twenty-three studies (ten cross-sectional and thirteen prospective cohort studies) were included in the systematic review. As regards the cross-sectional studies, the highest UPF consumption was associated with a significant increase in the risk of overweight/obesity (+39 %), high waist circumference (+39 %), low HDL-cholesterol levels (+102 %) and the metabolic syndrome (+79 %), while no significant associations with hypertension, hyperglycaemia or hypertriacylglycerolaemia were observed. For prospective cohort studies evaluating a total population of 183 491 participants followed for a period ranging from 3·5 to 19 years, highest UPF consumption was found to be associated with increased risk of all-cause mortality in five studies (risk ratio (RR) 1·25, 95 % CI 1·14, 1·37;P< 0·00001), increased risk of CVD in three studies (RR 1·29, 95 % CI 1·12, 1·48;P= 0·0003), cerebrovascular disease in two studies (RR 1·34, 95 % CI 1·07, 1·68;P= 0·01) and depression in two studies (RR 1·20, 95 % CI 1·03, 1·40;P= 0·02). In conclusion, increased UPF consumption was associated, although in a limited number of studies, with a worse cardiometabolic risk profile and a higher risk of CVD, cerebrovascular disease, depression and all-cause mortality.
Supplementing grass-based cattle feeds with legume leaves and its effects on manure quality and value as a soil improver for an Anthropic Ferralsol in Rwanda
Authors: Mukangango Marguerite , Nduwamungu Jean , Naramabuye Francois Xavier , Nyberg Gert , Dahlin A. Sigrun
Published: August 2020

Combined use of lime, animal manure and inorganic fertilisers is effective in replenishing the fertility of degraded acid soils. However, many smallholder farmers lack access to sufficient amounts of these inputs to improve the fertility and reduce the aluminium toxicity of Ferralsols. Organic manures are available but often have low nutrient content, which limits their ability to supply nutrients to soils. In a two-factor field experiment over four seasons on an Anthropic Ferralsol in Southern Province, Rwanda, we assessed (i) the effect of cattle manure on soil properties at a reduced rate affordable to smallholder farmers compared with that of NPK fertiliser applied, with and without lime also at a reduced rate, and (ii) the effect of supplementing grass in a basal cattle diet with legume leaves on manure quality and its effect on soil properties. Manure from cattle fed only the grass Chloris gayana (grass-only manure) and from cattle fed C. gayana supplemented with Acacia angustissima leaves (grass+legume manure) was applied at 5 t dry matter ha-1 (25% of the recommended rate) at the beginning of each growing season. NPK was applied as split doses supplying a total rate of 70 kg N ha-1. Lime was applied annually at a rate of 2.0 t CaO ha-1, which was 25% of the rate required to neutralise total acidity at the site. All amendments were applied only to the soil surrounding the maize plants (planting stations), which is estimated at 25% of the plot area. Maize stover was left on plots after harvest and planting stations were retained over all growing seasons. All treatments altered soil properties at the planting stations. Lime generally increased pH but there was no significant difference between lime plus manure treatments and non-limed manure treatments. Soil organic carbon concentration and cation exchange capacity were higher in manure and NPK treatments than in non-fertilised treatments. The manure treatment increased soil water-holding capacity compared with the NPK and non-fertilised treatments. There was no significant difference in total N, Ca2+, Mg2+ and K+ between the NPK and manure treatments. Micro-dosing animal manure can thus replace mineral fertiliser plus lime for soil fertility replenishment in smallholder farming. Grass+legume manure contained higher concentrations of total N, Ca, Mg, K and Na than grass-only manure, but its effect on soil properties did not differ significantly from that of grass-only manure.
A creaturely wisdom: Suffering, compassion and grace in Isaac of Nineveh
Authors: Duca Valentina
Published: August 2020

In the writings of Isaac of Nineveh, a seventh-century East Syriac solitary, one finds a profound compassion for every created being, including wild animals, heretics and demons. This article shows that this compassionate attitude towards external negative entities is rooted in the creature's relationship with its own condition of vulnerability. This vulnerability is distinctive of the human condition. Isaac conceives of the passions as attempts to remove this ontological condition, proposing that one can instead learn to deal with it and to ‘take it on’. This occurs through a demanding exercise of relationship with one's suffering self, and only once this relationship has been discovered does grace reveal itself to the creature. Grace, therefore, emerges from Isaac's writings as something that never removes one's creaturely poverty, but reveals itself only to the person who has the courage to experience, ‘bear’ and ‘take on’ this poverty.
Reliable knowledge, true freedom: The remnant of the analogia temporalis in the theology of Robert Jenson and its implications for the epistemology–freedom debate
Authors: Garton Alexander D.
Published: August 2020

While Karl Barth balances the reliability of revelation with divine counterfactual freedom through the analogia temporalis, Robert Jenson rejects this form of analogy, arguing that it posits an unknowable reality of God behind revelation. He instead transposes metaphysics into narratological terms, arguing that this secures the reliability of revelation and divine freedom, since it means God is future to (and so undetermined by) events in time. This metric for divine freedom cannot, however, replace counterfactual possibility; hence, the analogia temporalis (presupposed in counterfactuals) re-emerges in Jenson's theology. This form of analogy is essential in balancing the reliability of revelation with divine freedom.
Transmission of viral pathogens in a social network of university students: the eX-FLU study
Authors: Zivich P.N. , Eisenberg M.C. , Monto A.S. , Uzicanin A. , Baric R. S. , Sheahan T. P. , Rainey J. J. , Gao H. , Aiello A. E.
Published: August 2020

Previous research on respiratory infection transmission among university students has primarily focused on influenza. In this study, we explore potential transmission events for multiple respiratory pathogens in a social contact network of university students. University students residing in on-campus housing (n = 590) were followed for the development of influenza-like illness for 10-weeks during the 2012–13 influenza season. A contact network was built using weekly self-reported contacts, class schedules, and housing information. We considered a transmission event to have occurred if students were positive for the same pathogen and had a network connection within a 14-day period. Transmitters were individuals who had onset date prior to their infected social contact. Throat and nasal samples were analysed for multiple viruses by RT-PCR. Five viruses were involved in 18 transmission events (influenza A, parainfluenza virus 3, rhinovirus, coronavirus NL63, respiratory syncytial virus). Transmitters had higher numbers of co-infections (67%). Identified transmission events had contacts reported in small classes (33%), dormitory common areas (22%) and dormitory rooms (17%). These results suggest that targeting person-to-person interactions, through measures such as isolation and quarantine, could reduce transmission of respiratory infections on campus.
Resilience in the aftermath of hurricanes: Fluctuations in a Critically Endangered population of West Indian WoodpeckersMelanerpes superciliaris nyeanusover two decades
Authors: AKRESH MICHAEL E. , ASKINS ROBERT A. , KING DAVID I. , HAYES FLOYD E. , BARRY PATRICIA E. , HAYES WILLIAM K.
Published: August 2020

Cyclonic storms (often called hurricanes, typhoons, or cyclones) often cause population declines in vulnerable bird species, and the intensity of these storms appears to be increasing due to climate change. Prior studies have reported short-term impacts of hurricanes on avifauna, but few have examined long-term impacts. Over two decades (1993–2018), we periodically surveyed a subspecies of West Indian WoodpeckerMelanerpes superciliaris nyeanuson San Salvador, a small island in The Bahamas, to determine its distribution on the island, habitat use, and effects of hurricanes on abundance and population size. We conducted passive and playback surveys, supplemented with mist-netting. Woodpeckers were found only in the northern part of San Salvador, despite extensive surveys throughout other accessible areas of the island. Birds occupied areas with taller coppice adjacent to sabal palmSabal palmettogroves, which were used for nesting. After hurricanes with >160 kph winds passed over San Salvador, woodpecker densities declined to 35–40% of pre-hurricane densities, but generally recovered back to pre-hurricane densities within 2–3 years. Based on an estimated density of woodpeckers within a ~1,400 ha occupied area, we calculated a population size of approximately 240 individuals (CI = 68-408). However, the population declined to far lower numbers immediately following hurricanes. Under IUCN Red List criteria,M. s. nyeanusclassifies as ‘Critically Endangered’, and could be especially sensitive to future hurricanes if they occur at a high enough frequency or intensity to prevent the population from rebounding. Given the small size, isolation, and vulnerability of this population, we recommend preservation of the core habitat, continued monitoring, and further research. Our study shows that small, threatened bird populations can be resilient to the effects of hurricanes, but increased intensity of hurricanes, in combination with other threats, may limit this resilience in the future.
Excess mortality and shortened life expectancy in people with major mental illnesses in Taiwan
Authors: Pan Yi-Ju , Yeh Ling-Ling , Chan Hung-Yu , Chang Chin-Kuo
Published: August 2020

Aims

Given the concerns of health inequality associated with mental illnesses, we aimed to reveal the extent of which general mortality and life expectancy at birth in people with schizophrenia, bipolar disorder and depressive disorder varied in the 2005 and 2010 nationally representative cohorts in Taiwan.

Methods

Two nationally representative samples of individuals with schizophrenia, bipolar disorder and depressive disorder were identified from Taiwan's national health insurance database in 2005 and 2010, respectively, and followed-up for consecutive 3 years. The database was linked to nationwide mortality registry to identify causes and date of death. Age-, gender- and cause-specific mortality rates were generated, with the average follow-up period of each age- and gender-band applied as ‘weighting’ for the calculation of expected number of deaths. Age- and gender-standardised mortality ratios (SMRs) were calculated for these 3-year observation periods with Taiwanese general population in 2011/2012 as the standard population. The SMR calculations were then stratified by natural/unnatural causes and major groups of death. Corresponding life expectancies at birth were also calculated by gender, diagnosis of mental disorders and year of cohorts for further elucidation.

Results

The general differential in mortality rates for people with schizophrenia and bipolar disorder remained wide, revealing an SMR of 3.65 (95% confidence interval (CI): 3.55–3.76) for cohort 2005 and 3.27 (3.18-3.36) for cohort 2010 in schizophrenia, and 2.65 (95% CI: 2.55–2.76) for cohort 2005 and 2.39 (2.31-2.48) for cohort 2010 in bipolar disorder, respectively. The SMRs in people with depression were 1.83 (95% CI: 1.81–1.86) for cohort 2005 and 1.59 (1.57-1.61) for cohort 2010. SMRs due to unnatural causes tended to decrease in people with major mental illnesses over the years, but those due to natural causes remained relatively stable. The life expectancies at birth for schizophrenia, bipolar disorder and depression were all significantly lower than the national norms, specifically showing 14.97–15.50 years of life lost for men and 15.15–15.48 years for women in people with schizophrenia.

Conclusions

Compared to general population, the differential in mortality rates for people with major mental illnesses persisted substantial. The differential in mortality for unnatural causes of death seemed decreasing over the years, but that due to natural causes remained relatively steady. Regardless of gender, people with schizophrenia, bipolar disorder and depression were shown to have shortened life expectancies compared to general population.
Corona and the climate: a comparison of two emergencies
Authors: Vinke Kira , Gabrysch Sabine , Paoletti Emanuela , Rockström Johan , Schellnhuber Hans Joachim
Published: August 2020

Social media summary

Lessons from the corona crisis can help manage the even more daunting challenge of anthropogenic global warming.
Low carbohydrate diet score and odds of neuromyelitis optica spectrum	disorder: A case-control study
Authors: Rezaeimanesh Nasim , Jahromi Soodeh Razeghi , Ghorbani Zeinab , Moghadasi Abdorreza Naser , Hekmatdoost Azita , Moghadam Nahid Beladi , Sahraian Mohammad Ali
Published: August 2020

Abstract. Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating inflammatory disease of The Central nervous system. We aimed to investigate the association between low carbohydrate diet (LCD) and NMOSD odds. Method: Seventy NMOSD patients with definite diagnosis and 164 hospital-based controls were enrolled in this case-control study. Dietary data was obtained using a validated 168-item food frequency questionnaire. To determine the LCD score, participants were stratified into 11 groups according to carbohydrate, protein, fat, animal fat, animal protein, vegetable fat and vegetable protein intakes. Higher intake of protein and fat, and lower intake of carbohydrate received a higher score between 0-10. Macronutrients scores were summed together and LCD scores calculated. The association between LCD scores and likelihood of being assigned to NMOSD group was investigated using multiple regression models. Results: Total LCD scores increased from the median of 21.00 in the first decile to 53.00 in the tenth decile of LCD score. After adjustment for confounding factors including age, gender, BMI, energy intake, cigarette smoking and alcohol consumption, an inverse association was detected between LCD scores and odds of NMOSD. The odds of suffering from NMOSD declined significantly about 78% (OR: 0.22; 95% CI: 0.05–0.87) and 76% (OR: 0.24; 95% CI: 0.06–0.93) in the fifth and sixth deciles of LCD score compared to the first decile. Conclusion: From the obtained results it can be speculated that higher carbohydrate and lower protein and fat intakes may be associate with the increased odds of NMOSD. However, further studies are needed to confirm these results.
AMOC Recovery in a Multicentennial Scenario Using a Coupled Atmosphere‐Ocean‐Ice Sheet Model
Authors: Ackermann L. , Danek C. , Gierz P. , Lohmann G.
Published: August 2020

We simulate the two Coupled Model Intercomparison Project scenarios RCP4.5 and RCP8.5, to assess the effects of melt‐induced fresh water on the Atlantic meridional overturning circulation (AMOC). We use a newly developed climate model with high resolution at the coasts, resolving the complex ocean dynamics. Our results show an AMOC recovery in simulations run with and without an included ice sheet model. We find that the ice sheet adds a strong decadal variability on the freshwater release, resulting in intervals in which it reduces the surface runoff by high accumulation rates. This compensating effect is missing in climate models without dynamic ice sheets. Therefore, we argue to assess those freshwater hosing experiments critically, which aim to parameterize Greenland's freshwater release. We assume the increasing net evaporation over the Atlantic and the resulting increase in ocean salinity, to be the main driver of the AMOC recovery.
Large‐Scale Desalination and the External Impact on Irrigation‐Water Salinity: Economic Analysis for the Case of Israel
Authors: Slater Yehuda , Finkelshtain Israel , Reznik Ami , Kan Iddo
Published: August 2020

Recent agroeconomic studies in water‐scarce countries such as Spain, Australia, Saudi Arabia, and Israel have revealed the economic viability of irrigating high‐value crops with desalinated water. However, the worldwide growth of large‐scale desalination capacities is primarily designed to resolve urban‐water scarcity, disregarding the impact of desalination on irrigation‐water salinity. We develop a dynamic hydroeconomic programming model where infrastructure capacities and allocations of water quantities and salinities in a regional water distribution network are endogenous. We show that subsidizing desalination is socially warranted because the associated reduction in irrigation‐water salinity is an external effect of water consumption by all water users. Empirical application to the entire state of Israel indicates that large‐scale desalination of seawater and treated wastewater for irrigation is optimal. This result stems from the large share of irrigation‐intensive salinity‐sensitive high‐value crops, motivated by Israel's policies to support local agriculture. Ignoring salinity results in a 45% reduction in desalinated irrigation water, a 29% reduction in farming profits, a 250% increase in water suppliers' profits, and an average deadweight loss of $1,200 a year per hectare of arable land.
Lake Ice—and Ecosystems—in a Warming World
Authors: Cook Terri
Published: August 2020

Extending ice records and standardizing sampling protocols are among recommendations to help researchers better predict how changing ice cover will affect aquatic ecosystems.