bluuebunny/crossref_metadata_2025 huggingface dataset:
The BV action of 3D twisted R-Poisson sigma models
Authors: Chatzistavrakidis Athanasios , Ikeda Noriaki , Šimunić Grgur
Published: October 2022

Abstract

We determine the solution to the classical master equation for a 3D topological field theory with Wess-Zumino term and an underlying geometrical structure of a twisted R-Poisson manifold on its target space. The graded geometry of the target space departs from the usual QP structure encountered in the AKSZ construction of topological sigma models, the obstruction being attributed to the presence of the Wess-Zumino 4-form. Due to the inapplicability of the AKSZ construction in this case, we set up the traditional BV/BRST formalism for twisted R-Poisson sigma models in any dimension, which feature an open gauge algebra and constitute multiple stages reducible constrained Hamiltonian systems. An unusual feature of the theories is that they exhibit non-linear openness of the gauge algebra, in other words products of the equations of motion appear in them. Nevertheless, we find the BV action in presence of the 4-form twist in 3D, namely for a specific 4-form twisted (pre-)Courant sigma model. Moreover, we provide a complete set of explicit formulas for the off-shell nilpotent BV operator for untwisted R-Poisson sigma models in any dimension.
Gravity and the crossed product
Authors: Witten Edward
Published: October 2022

Abstract

Recently Leutheusser and Liu [1, 2] identified an emergent algebra of Type III1 in the operator algebra of $$ \mathcal{N} $$
N
= 4 super Yang-Mills theory for large N. Here we describe some 1/N corrections to this picture and show that the emergent Type III1 algebra becomes an algebra of Type II∞. The Type II∞ algebra is the crossed product of the Type III1 algebra by its modular automorphism group. In the context of the emergent Type II∞ algebra, the entropy of a black hole state is well-defined up to an additive constant, independent of the state. This is somewhat analogous to entropy in classical physics.
Posterior acetabular wall morphology is an independent risk factor that affects the occurrence of acetabular wall fracture in patients with traumatic, posterior hip dislocation
Authors: Graulich Tilman , Gräff Pascal , Omar Pacha Tarek , Örgel Marcus , Macke Christian , Omar Mohamed , Krettek Christian , Liodakis Emmanouil
Published: October 2022

Purpose

Smaller posterior acetabular walls have been shown to independently influence the risk for bipolar hip dislocation. We asked whether differences would also be observed in patients with traumatic posterior hip dislocation with and without posterior wall fractures.

Methods

Between 2012 and 2020 we observed 67 traumatic posterior hip dislocations. Of these, 43 traumatic posterior hip dislocations in 41 patients met the inclusion criteria. Eighteen dislocations were excluded with an acetabular fracture other than posterior wall fracture and six dislocations had insufficient computed tomography (CT) data. The mean age was 41 ± 11 years, 32 males and nine females. We observed 26 traumatic hip dislocations with posterior wall fractures and 17 without. All patients underwent polytrauma CT scans and postoperative/postinterventional pelvic CT scans. On axial CT-scans, posterior wall determining angles were measured.

Results

Patients with posterior wall fractures were not significantly older than patients without posterior wall fractures (42 ± 12 vs. 38 ± 10 years; p = 0.17). Patients without posterior wall fractures had significantly smaller posterior acetabular sector angles (84° ± 10°) than did patients with posterior wall fractures (105° ± 12°) (p < 0.01; OR 1.178). Likewise, the posterior wall angle was significantly smaller in patients without posterior wall fracture (62° ± 9°) than in those with posterior wall fractures (71° ± 8°) (p < 0.01; OR 1.141).

Conclusion

Both posterior acetabular sector angle and posterior wall angle are independent factors determining the posterior wall fracture morphology in patients with traumatic posterior hip dislocation. Age and the observed trauma mechanism did not differentiate between traumatic posterior hip dislocations with and without posterior wall fractures.
LC–MS/MS and GC–MS based phytochemical perspectives and antimicrobial effects of endophytic fungus Chaetomium ovatoascomatis isolated from Euphorbia milii
Authors: Shaker Kamel H. , Zohair Moustafa M. , Hassan Amal Z. , Sweelam Heba-tollah M. , Ashour Warda E.
Published: October 2022

The antimicrobial activity of endophytic fungi isolated from Euphorbia milii was evaluated against Gram-positive, Gram-negative bacteria, unicellular yeast, and filamentous fungi. Chaetomium ovatoascomatis NRC was identified morphologically and genetically as the most active strain. The total ethyl acetate extract of C. ovatoascomatis NRC demonstrated significant antimicrobial activity against Gram-negative; Escherichia coli, Salmonella enteric, and fungi; Aspergillus niger with MIC of 62.5 ug/ml. Whereas n-hexane fraction demonstrated broader activity against Gram-positive; Bacillus subtilis, Lactobacillus cereus, Gram-negative; Escherichia coli and Salmonella enteric, fungi; Candida albicans and F. solani. LC–MS/MS analysis of ethyl acetate strain extract and GC–MS analysis of the n-hexane fraction were used to identify the metabolites of the strain extract. LC–MS/MS determined three major metabolites with potential antimicrobial activities including grevilline B, aflatoxin G2 and apigenin. GC–MS analysis of n-hexane fraction tentatively identified 30 compounds, where 9,12-octadecadienoic acid methyl ester was the major compound.
Ferroptosis Inducers in Thyroid Cancer
Authors: Sekhar Konjeti R. , Cyr Sriram , Baregamian Naira
Published: October 2022

Purpose

Papillary thyroid carcinoma (PTC) progression imparts reduced patient survival. Tumor resistance and progression can be influenced by Glutathione (GSH) metabolism. Glutathione peroxidase 4 (GPX4) regulates GSH oxidation to prevent lipid peroxidation of cell membranes during increased oxidative stress and regulates ferroptosis cell death pathway in tumor cells. This study examines the differential ferroptosis effects by GPX4 inhibitors in thyroid cancer cell and 3‐D spheroid in vitro models.

Materials and methods

We examined differential effects of GPX4 inhibitors on PTC cells (K1, MDA‐T32, MDA‐T68) with BRAF and RAS mutations, and TERT promoter and PIK3CA co‐mutations. The effects of GPX4 inhibitors on ferroptosis activation, proliferation, oxidative stress, and activation of signaling pathways were assessed by Western blot, total (GSH) and oxidized glutathione (GSSG) levels, ROS induction, RT‐qPCR, migration, and proliferation assays.

Results

GPX4 inhibitors induced ferroptosis, rising ROS, GSH depletion, arrested tumor cell migration, increased DNA damage, suppressed mTOR pathway and DNA repair response in PTC cells in vitro. Differential responses to DNA damage and GPX4 levels were observed between 3‐D PTC spheroids and thyroid cancer cells in a monolayer model.

Conclusion

Effective GPX4 inhibition with various inhibitors induced a robust but differential activation of ferroptosis in monolayer thyroid tumor cell and 3‐D PTC spheroid models. Our study is the first of its kind to determine the differential effects of GPX4 inhibitors on thyroid cancer cells with diverse mutational signatures. We have identified a novel mechanism of action of GPX4 inhibition in preclinical in vitro models of thyroid cancer that can be further exploited for therapeutic benefit in advanced therapy‐resistant thyroid cancers.
Parathyroidectomy for Normocalcemic Primary Hyperparathyroidism is Associated with Improved Bone Mineral Density Regardless of Postoperative Parathyroid Hormone Levels
Authors: Lui Michael S. , Clemente‐Gutierrez Uriel , Vodopivec Danica M. , Chang Shandel L. , Shirali Aditya S. , Huang Bernice L. , Chiang Yi‐Ju , Fisher Sarah B. , Grubbs Elizabeth G. , Guise Theresa A. , Graham Paul H. , Perrier Nancy D.
Published: October 2022

Background

Biochemical cure in normocalcemic primary hyperparathyroidism (nPHPT) is defined as parathyroid hormone (PTH) level normalization 6 months after parathyroidectomy. However, recent studies show that a significant number of nPHPT patients have persistent PTH elevation postoperatively. We sought to correlate changes in PTH levels with skeletal outcomes after parathyroidectomy in nPHPT patients.

Methods

Adult patients who underwent parathyroidectomy at a tertiary referral center for sporadic PHPT between 2010 and 2020 were reviewed. Pre‐ and postoperative (6 months, 18 months, and last follow‐up) laboratory and bone mineral densities (BMD) were recorded. Primary outcome was 18‐month postoperative BMD change in the lumbar spine (LS), total hip (TH) and femoral neck (FN) in normocalcemic and hypercalcemic PHPT (hPHPT) patients.

Results

Of 661 patients included, 68 had nPHPT. nPHPT patients frequently had multigland disease (31% vs. 18%, p = 0.014), more bilateral cervical explorations (22% vs. 13%, p = 0.042), and fewer achieved biochemical cure (76% vs. 95%, p < 0.001) than hPHPT patients. Twenty‐eight nPHPT patients had BMD data for comparison. Overall, nPHPT patients had improvement in the LS (1.84%, p = 0.002) and TH (1.64%, p = 0.014). When stratified by postoperative PTH levels, nPHPT patients with persistent PTH elevation had more BMD improvement at the TH than those who normalized PTH (3.73% vs. − 0.83%, p = 0.017). There was no difference in improvement at the LS or FN (p = NS).

Conclusion

Parathyroidectomy is associated with improved BMD in nPHPT patients with bone disease. Although one in four nPHPT patients had elevated postoperative PTH levels persisting throughout the study, BMD improvement was still seen regardless of postoperative PTH level normalization.
Studies on the interactions of retinal dopamine with choroidal thickness in the chicken
Authors: Mathis Ute , Feldkaemper Marita , Liu Hong , Schaeffel Frank
Published: October 2022

Purpose

Recently, an increasing number of studies relied on the assumption that visually induced changes in choroidal thickness can serve as a proxy to predict future axial eye growth. The retinal signals controlling choroidal thickness are, however, not well defined. We have studied the potential roles of dopamine, released from the retina, in the choroidal response in the chicken.

Methods

Changes in retinal dopamine release and choroidal thickness changes were induced by intravitreal injections of either atropine (250 µg or 360 nMol), atropine combined with a dopamine antagonist, spiperone (500 µMol), or spiperone alone and were tracked by optical coherence tomography (OCT). To visually stimulate dopamine release, other chicks were exposed to flicker light of 1, 10, or 400 Hz (duty cycle 0.2) and choroidal thickness was tracked. In all experiments, dopamine and 3,4-Dihydroxyphenylacetic acid (DOPAC) were measured in vitreous, retina, and choroid by high-performance liquid chromatography with electrochemical detection (HLPC-ED). The distribution of the rate-limiting enzyme of dopamine synthesis, tyrosine hydroxylase (TH), neuronal nitric oxide synthase (nNOS), vascular endothelial growth factor (VEGF), and alpha2A adrenoreceptors (alpha2A-ADR) was studied in the choroid by immunofluorescence.

Results

The choroid thickened strongly in atropine-injected eyes, less so in atropine + spiperone–injected eyes and became thinner over the day in spiperone alone-, vehicle-, or non-injected eyes. Flickering light at 20 lx, both 1 and 10 Hz, prevented diurnal choroidal thinning, compared to 400 Hz, and stimulated retinal dopamine release. Correlation analysis showed that the higher retinal dopamine levels or release, the thicker became the choroid. TH-, nNOS-, VEGF-, and alpha2A adrenoreceptor–positive nerve fibers were localized in the choroid around lacunae and in the walls of blood vessels with colocalization of TH and nNOS, and TH and VEGF.

Conclusions

Retinal DOPAC and dopamine levels were positively correlated with choroidal thickness. TH-positive nerve fibers in the choroid were closely associated with peptides known to play a role in myopia development. Findings are in line with the hypothesis that dopamine is related to retinal signals controlling choroidal thickness.
Molecular (cox1), geographical, and host record investigation of monogeneans Mazocraes australis (Mazocraeidae), Polylabris sillaginae, and P. australiensis (Microcotylidae)
Authors: Hossen Md. Shafaet , Barton Diane P. , Wassens Skye , Shamsi Shokoofeh
Published: October 2022

This study determines the occurrence and molecular characterisation of Monogenea from three commercially important Australian fish: Australian sardine Sardinops sagax (Jenyns), Australian anchovy Engraulis australis (White), and eastern school whiting Sillago flindersi McKay. Earlier studies have provided only morphological species identification, whereas this study combines both morphological and molecular methods. A total of 247 fish across 3 species, sourced from the New South Wales and Victorian coasts, were examined for Monogenea. A total of 187 monogenean parasites were recovered from the gills. The overall prevalence, mean intensity, and mean abundance were 34%, 2.23, and 0.78, respectively. The parasites were initially classified morphologically as three species across two families. Family Mazocraeidae was represented by Mazocraes australis Timi et al. J Parasitol 85:28–32, 1999, and family Microcotylidae by Polylabris sillaginae (Woolcock, Parasitology 28:79–91, 1936) Dillon, Hargis, and Harrises, 1983 and P. australiensis Hayward, 1996. Molecular identification of parasites was conducted through sequencing of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene. The fish hosts in the present study were also barcoded (mitochondrial cox1 gene) to confirm specific identities. There was no comparable cox1 sequence available in GenBank for the parasites found in the present study. However, the phylogenetic tree clustered the monogenean species identified in this study according to their familial groups of Mazocraeidae and Microcotylidae. The presence of M. australis on E. australis and S. sagax was confirmed in this study. Polylabris australiensis was only found on S. sagax but Si. flindersi was found to be a host for both Polylabris species. This study is the first to explore the mitochondrial cox1 genes of these three-monogenean species. These findings will serve as a foundation for future monogenean research in Australian waters and elsewhere.
„Psychologe war so Luxusgeschenk“ – emotionale Herausforderungen und psychoonkologische Versorgungsbedarfe von Menschen mit einer Lungenkrebsdiagnose
Authors: Fügemann Hella , Goerling Ute , Gödde Kathrin , Rieckmann Nina , Holmberg Christine
Published: October 2022

Hintergrund

Lungenkrebsbetroffene sind besonders stark durch psychischen Stress belastet. Gleichzeitig sind die Inanspruchnahmeraten von psychoonkologischer Unterstützung relativ gering. Es ist wenig über die Gründe der (Nicht‑)Inanspruchnahme bekannt.

Fragestellung

Welche emotionalen Herausforderungen erleben Menschen mit Lungenkrebs? Was sind ihre Gründe für die (Nicht‑)Inanspruchnahme psychoonkologischer Unterstützung?

Material und Methode

Es wurden qualitative Interviews mit 20 Lungenkrebsbetroffenen ausgewertet, die im Rahmen der CoreNAVI-Studie durchgeführt wurden.

Ergebnisse

Die Befragten erleben psychischen Stress in Form von Unsicherheiten und Zukunftsängsten. Auch den Druck, schnell von einer Behandlung in die nächste gehen zu müssen und keine Zeit für sich zu haben, nehmen die Betroffenen als belastend wahr. Das offene Sprechen, ohne das persönliche Umfeld belasten zu müssen, sowie konkrete Ratschläge erleben die Nutzer*innen der Psychoonkologie als große Hilfestellung. Die Nichtinanspruchnahme wird durch fehlenden Bedarf und mangelnde Kapazitäten begründet. Zudem werden Vorbehalte gegenüber psychologischer Unterstützung deutlich.

Schlussfolgerung

Betroffene mit Lungenkrebs erleben psychische und emotionale Belastungen auch durch die Vielzahl und Dichte an Therapien. Daraus resultierende fehlende Kapazitäten könnten eine Erklärung für die geringe Inanspruchnahme von psychoonkologischer Unterstützung sein. Eine stärkere Gewichtung der Psychoonkologie gegenüber aufwendigen medizinischen, oft nur geringfügig lebensverlängernden Therapien sowie der Abbau von Vorbehalten gegenüber psychologischer Hilfe sollten in der Versorgungspraxis verstärkt in den Fokus rücken.
Determinants and outcomes of bloodstream infections related to obesity
Authors: Edwards Felicity , Glen Kate , Harris Patrick N. A. , Paterson David L. , Laupland Kevin B.
Published: October 2022

Although obesity is a major healthcare problem that is increasing in many populations worldwide, there are limited studies that have examined its contribution to infectious diseases morbidity and mortality. The aim of this study was to examine the clinical determinants and outcomes of bloodstream infections among patients with obesity. All adults within the publicly funded healthcare system in Queensland, Australia, identified with a BSI during 2017–2019 were included and the presence of obesity was based on discharge International Classification of Diseases (ICD-10) codes. Clinical features, microbiology, and outcomes were compared among obese and non-obese subjects. A total of 24,602 incident BSI were identified among 21,613 Queensland residents; of which 4,579 (21.2%) and 17,034 (78.8%) were classified as obese or non-obese, respectively. Obese patients were less likely to have community associated infections and were more likely to be younger, female, have higher comorbidity scores, and have bone and joint or soft tissue infections as compared to non-obese subjects. Obese patients had a lower proportion of Escherichia coli BSI and higher proportions of b-haemolytic streptococci. Although obese patients had longer hospital admissions and more repeat incident BSI within 1 year, they had lower overall case fatality. In a logistic regression model, obesity was associated with a lower risk for 30-day case fatality (adjusted odds ratio 0.51, 95% confidence interval 0.45–0.58). Obesity is associated with significant differences in the determinants and outcome of BSI. Increasing rates of obesity is likely to influence the epidemiology of BSI in populations.
Does competition improve hospital performance: a DEA based evaluation from the Netherlands
Authors: Dohmen Peter , van Ineveld Martin , Markus Aniek , van der Hagen Liana , van de Klundert Joris
Published: October 2022

Many countries have introduced competition among hospitals aiming to improve their performance. We evaluate the introduction of competition among hospitals in the Netherlands over the years 2008–2015. The analysis is based on a unique longitudinal data set covering all Dutch hospitals and health insurers, as well as demographic and geographic data. We measure hospital performance using Data Envelopment Analysis and distinguish three components of competition: the fraction of freely negotiated services, market power of hospitals, and insurer bargaining power. We present new methods to define variables for each of these components which are more accurate than previously developed measures. In a multivariate regression analysis, the variables explain more than half of the variance in hospital efficiency. The results indicate that competition between hospitals and the relative fraction of freely negotiable health services are positively related to hospital efficiency. At the same time, the policy measure to steadily increase the fraction of health services contracted in competition may well have resulted in a decrease in hospital efficiency. The models show no significant association between insurer bargaining power and hospital efficiency. Altogether, the results offer little evidence that the introduction of competition for hospital care in the Netherlands has been effective.
Viewing Time Measures of Sexual Interest and Sexual Offending Propensity: An Online Survey of Fathers
Authors: Pezzoli Patrizia , Babchishin Kelly , Pullman Lesleigh , Seto Michael C.
Published: October 2022

Relative viewing times (VTs)—time required to view and evaluate sexually salient images—discriminate individuals with a sexual interest in children, as indirectly indexed by their history of sexual offending against children, from those without such history. In an online sample of 652 fathers, we measured VTs and sexual attraction ratings to child and adult images. We assessed participants’ sexual offending history and propensity (self-reported likelihood to have a sexual contact with a child, a non-consensual sexual contact with an adult, and propensity toward father–daughter incest). In contrast with VT studies involving clinical or forensic samples, VTs and attraction ratings failed to discriminate participants with a sexual offending history. VTs successfully distinguished participants with a propensity to sexually offend against children but failed to identify those with a propensity toward incest. Conversely, attraction ratings distinguished participants with a propensity toward incest but failed to identify those with a propensity to sexually offend against children. Correlations between VTs and attraction ratings were small. Results illustrate, for the first time, the distribution of VT measures in community fathers, support the feasibility of online administration of VT tasks to detect propensity to sexually offend against children, and indicate that sexual interest in children and incest propensity are distinct.
Synthesis of glycyrrhetinic acid-modified liposomes to deliver Murrayafoline A for treatment of hepatocellular carcinoma
Authors: Dinh Cuc Thi , Vu Ha Thi , Phan Quynh Thi Huong , Nguyen Linh Phuong , Tran Toan Quoc , Van Tran Dung , Quy Nguyen Ngoc , Pham Dung Thuy Nguyen , Nguyen Duong Thanh
Published: October 2022

Hepatocellular carcinoma is a common type of cancer associated with a high mortality rate. Among several bioactive compounds, Murrayafoline A (MuA) has been proved as a bio substance that exhibits great potentials in treating liver cancer. In order to overcome the high cytotoxicity and low solubility of MuA, a delivery system based on nanocarriers is necessary to deliver MuA towards the desired target. In the present study, 18β-glycyrrhetinic acid (GA), which is known as a ligand for liver targeting, was used to construct the cholesterol-poly (ethylene glycol)-glycyrrhetinic acid (GA-PEG-Chol) conjugate and liposome for MuA administration. The compound was then examined for therapeutic efficacy and safety in HUVEC and HepG2 cells in 2D and 3D cell cultures. Results have shown that MuA-loaded liposomes had IC50 value of 2 µM in HepG2 and had the cytosolic absorption of 8.83 ± 0.97 ng/105 cells, while The IC50 value of MuA-loaded liposomes in HUVEC cell lines was 15 µM and the the cytosolic absorption was recorded as 3.62 ± 0.61 cells. The drug test on the 3D cancer sphere platform of the HepG2 cancer sphere showed that MuA-loaded GA liposomes had the highest efficacy at a concentration of 100 µg/mL. In short, these results suggest that MuA-loaded GA liposomes have the potential for maintenance drug delivery and liver targeting.
Acting on Values: A Novel Intervention Enhancing Hedonic and Eudaimonic Well-Being
Authors: Bojanowska Agnieszka , Kaczmarek Łukasz D. , Urbanska Beata , Puchalska Malwina
Published: October 2022

Individuals increase well-being by acting on their values rather than merely endorsing them. We developed a novel intervention (“Acting on Values,” AoV), motivating individuals to initiate values-related behavior over four weeks. Building upon the theory of Basic Human Values, we expected that intervention recipients would increase their hedonic and eudaimonic well-being relative to a control group. We also expected the AoV interventions to cause similar effects as a mindfulness group. 783 volunteers (N = 268 completers) were assigned into three groups: AoV intervention, mindfulness, and a waiting list. Individuals who completed the AoV intervention achieved higher satisfaction with life, positive affect, and eudaimonic well-being, and lower negative affect than the control group. The well-being effects of the AoV intervention did not differ significantly from the mindfulness intervention effects. Our findings suggest that the AoV intervention is an efficacious method of increasing hedonic and eudaimonic well-being. It contributes to the diversity of well-being facilitation methods.
A Novel Thermo-Mechanical Processing Route Exploiting Abnormal Grain Growth in Heusler-Type Co–Ni–Ga Shape Memory Alloys
Authors: Lauhoff C. , Pham T. , Paulsen A. , Krooß P. , Frenzel J. , Eggeler G. , Niendorf T.
Published: October 2022

Heusler-type Co–Ni–Ga shape memory alloys attracted significant scientific attention owing to excellent superelasticity in single-crystalline state. However, due to pronounced anisotropy, polycrystalline Co–Ni–Ga suffers from transformation-induced constraints at grain boundaries and, thus, premature failure upon thermo-mechanical loading. The present study reports on a novel thermo-mechanical processing route. Hot rolling followed by solution-annealing promotes abnormal grain growth, eventually leading to high-performance single-crystalline structures. The procedure proposed offers great potential for a direct microstructure design.
Bacteria inactivation by sulfate radical: progress and non-negligible disinfection by-products
Authors: Zhou Xin , Ren Xiaoya , Chen Yu , Feng Haopeng , Yu Jiangfang , Peng Kang , Zhang Yuying , Chen Wenhao , Tang Jing , Wang Jiajia , Tang Lin
Published: October 2022

Sulfate radicals have been increasingly used for the pathogen inactivation due to their strong redox ability and high selectivity for electron-rich species in the last decade. The application of sulfate radicals in water disinfection has become a very promising technology. However, there is currently a lack of reviews of sulfate radicals inactivated pathogenic microorganisms. At the same time, less attention has been paid to disinfection by-products produced by the use of sulfate radicals to inactivate microorganisms. This paper begins with a brief overview of sulfate radicals’ properties. Then, the progress in water disinfection by sulfate radicals is summarized. The mechanism and inactivation kinetics of inactivating microorganisms are briefly described. After that, the disinfection by-products produced by reactions of sulfate radicals with chlorine, bromine, iodide ions and organic halogens in water are also discussed. In response to these possible challenges, this article concludes with some specific solutions and future research directions.
Optimal Design of the Superstructure of an Offshore Tourism Platform by Using Numerical Simulation
Authors: Yang Ruquan , Wang Hongbo , Chen Chaohe
Published: October 2022

This paper aims to reduce the wind resistance of the self-designed offshore tourism platform by optimizing its superstructure, and a transparent shape design is finally suggested. A numerical simulation was performed to calculate the wind load on the platform to test the effect of wind resistance reduction. Two original scale models (sealed and transparent) were established in accordance with the design requirements. The numerical simulation uses the FLUENT software combined with the built-in self-compiled user-defined function (UDF). The stochastic wind was also applied on the basis of the Davenport wind spectrum. The detached eddy simulation (DES) model was used to solve the NS equation. Numerical simulation results show that the wind resistance reduction for the transparent shape model is subtle in the horizontal direction but can effectively reduce the drag force and moment in the vertical direction. Moreover, the force variation of the transparent shape model under different wind attack angles decreases, which reduces the wind load fluctuations.
Consent for Medical Treatment of Trans Youth
Authors: Jowett Steph
Published: October 2022

Access to medical treatment for trans youth occupies a haphazard and dynamic legal landscape. In this comprehensive scholarly analysis of the historical and current legal principles, Steph Jowett examines the medico-legal nexus of regulation of this healthcare in Australia and in England and Wales. This is informed by an in-depth discussion of the medical literature on treatment for trans youth, including clinical guidelines, the outcomes of treatment and outcomes for trans youth who are unable to be treated. With illustrative examples and clear language, Jowett argues that legal barriers to clinical practice should be congruent with and reflect the current state of medical knowledge. Not only does Jowett assess the extent to which key legal decisions have been consistent with medical knowledge in the past, but she offers a nuanced, comparative perspective that will inform reform efforts in the future.
Existence of the zero-temperature limit of equilibrium states on topologically transitive countable Markov shifts
Authors: BELTRÁN ELMER , LITTIN JORGE , MALDONADO CESAR , VARGAS VICTOR
Published: October 2022

Consider a topologically transitive countable Markov shift
$\Sigma $
and a summable locally constant potential
$\phi $
with finite Gurevich pressure and
$\mathrm {Var}_1(\phi ) < \infty $
. We prove the existence of the limit
$\lim _{t \to \infty } \mu _t$
in the weak
$^\star $
topology, where
$\mu _t$
is the unique equilibrium state associated to the potential
$t\phi $
. In addition, we present examples where the limit at zero temperature exists for potentials satisfying more general conditions.
Induced dormancy in Indian meal moth Plodia interpunctella (Hübner) and its impact on the quality improvement for mass rearing in parasitoid Habrobracon hebetor (Say)
Authors: Hasan Md. Mahbub , Hasan Md. Mehedi , Rahman A. S. M. Shafiqur , Athanassiou Christos G. , Tussey Dylan A. , Hahn Daniel A.
Published: October 2022

A steady supply of hosts at the susceptible stage for parasitism is a major component of mass rearing parasitoids for biological control programs. Here we describe the effects of storing 5th instar Plodia interpunctella larvae in dormancy on subsequent host development in the context of host colony maintenance and effects of the duration of host dormancy on the development of Habrobracon hebetor parasitoids reared from dormant hosts. We induced dormancy with a combination of short daylength (12L:12D) and lower temperature (15°C), conditions known to induce diapause in this species, and held 5th instar larvae of P. interpunctella for a series of dormancy durations ranging from 15 to 105 days. Extended storage of dormant 5th instar larvae had no significant impacts on survival, development, or reproductive potential of P. interpunctella, reinforcing that dormant hosts have a substantial shelf life. This ability to store hosts in dormancy for more than 3 months at a time without strong negative consequences reinforces the promise of using dormancy to maintain host colonies. The proportion of hosts parasitized by H. hebetor did not vary significantly between non-dormant host larvae and dormant host larvae stored for periods as long as 105 days. Concordant with a prior study, H. hebetor adult progeny production from dormant host larvae was higher than the number of progeny produced on non-dormant host larvae. There were no differences in size, sex ratio, or reproductive output of parasitoids reared on dormant hosts compared to non-dormant hosts stored for up to 105 days. Larval development times of H. hebetor were however longer when reared on dormant hosts compared to non-dormant hosts. Our results agree with other studies showing using dormant hosts can improve parasitoid mass rearing, and we show benefits for parasitoid rearing even after 3 months of host dormancy.
Glory and Humiliation in the Making of V. D. Savarkar's Hindu Nationalism
Authors: Visana Vikram
Published: October 2022

In the European tradition, political emotion in the form of individual and collective glory was usually constrained by norms of legitimate political conduct defined by public virtue. This article describes an alternative relationship between glory and political reason by reconstructing the political thought of V. D. Savarkar, the architect of Hindu nationalism. The article argues that the relational concepts of glory and humiliation were at the heart of actualizing ‘Hindu-ness’ or Hindutva as a sovereign political category. The genealogy and development of Hindu nationalism is traced from the formative space of the colonial prison during Savarkar's incarceration from 1911 to 1937, the ideology's subsequent refining and dissemination, to its final form after Partition in 1947. Supplementing Savarkar's political treatises and histories, this article is the first to analyse his poetry as political thought. Together, these writings show how scriptural Hindu concepts like the gunas and prakriti were appropriated to justify a fraught majoritarian unity defined against endogenous shame sanctions and exogenous humiliation. In order to achieve this, political reason was yoked to a perspectivist history enabling Hindu self-overcoming, which was personified by communal heroes who embodied a passionate Hindu will to power.
Intersectional Inequalities in Anthropometric Failure among Indian Children: Evidence from the National Family Health Survey (2015-2016)
Authors: Adhikari Tulsi , Tripathi Niharika , Yadav Jeetendra , Tolani Himanshu , Rao M. Vishnu Vardhana , Kaur Harpreet , Chalga Manjeet Singh
Published: October 2022

Increasing body of health planning and policy research focused upon unravelling the fundamental drivers of population health and nutrition inequities, such as wealth status, educational status, caste/ethnicity, gender, place of residence, and geographical context, that often interact to produce health inequalities. However, very few studies have employed intersectional framework to explicitly demonstrate how intersecting dimensions of privilege, power, and resources form the burden of anthropometric failures of children among low-and-middle income countries including India. Data on 2,15,554 sampled children below 5 years of age from the National Family Health Survey 2015-2016 were analysed. This study employed intersectional approach to examine caste group inequalities in the anthropometric failure (i.e. moderate stunting, severe stunting, moderate underweight, severe underweight, moderate wasting, severe wasting) among children in India. Descriptive statistics and multinomial logistic regression models were fitted to investigate the heterogeneities in the burden of anthropometric failure across demographic, socioeconomic and contextual factors. Interaction effects were estimated to model the joint effects of socioeconomic position (household wealth, maternal education, urban/rural residence and geographical region) and caste groups with the likelihood of anthropometric failure among children.

More than half of under-5 children suffered from anthropometric failure in India. Net of the demographic and socioeconomic characteristics, children from the disadvantageous caste groups whose mother were illiterate, belonged to economically poor households, resided in the rural areas, and coming from the central and eastern regions experienced disproportionately higher risk of anthropometric failure than their counterparts in India. Concerted policy processes must recognize the existing heterogeneities between and within population groups to improve the precision targeting of the beneficiary and enhance the efficiency of the nutritional program among under-5 children, particularly for the historically marginalized caste groups in India.
Hadrian in Germany and the Construction of the Limes Palisade in a.d. 120
Authors: Thiel Andreas
Published: October 2022

Germania Inferior and Germania Superior, along the Rhine, and neighbouring Raetia were provinces inherited by Hadrian which lacked major external threats and had the potential to become flourishing parts of the Roman Empire. Relying on his personal knowledge of the regional situation he strengthened civilian self-government by gradually reducing the role of the military. Apart from the legions, all other units were stationed in a small defined cordon at the edge of Roman territory. Together with the now well-dated building of the palisade as a continuous running barrier, Hadrian's initiatives might be seen as an imperial gift to the provincials.
Making Food Modernity: Science and Technology in Late Soviet Nutrition and Food Production
Authors: Kochetkova Elena
Published: October 2022

From the mid-1950s, industrial food manufacturing has become a key priority of the Soviet economy. Increasing the production of agricultural and manufactured foodstuffs was a matter of improving living standards, which from 1961 the Soviet leadership declared as a crucial step in achieving the aims of communism. At the same time, since the 1950s and 1960s, the role of science and technology in making food products has significantly increased, promising improvements in both the quantity and quality of nutrition. Specialists played a key role in incorporating traditional foods into the complex nexus of modern science and technologies of production and they developed new qualities of food they called ‘modern’. Food modernity was based on the strong belief in the power of chemical elements, microbiology and modern technologies of production to make healthier, tastier and more sustainable food products. By the 1970s, hygiene also became a crucial element of production, incorporated into the system of labour incentives at Soviet enterprises. These attempts, however, co-existed with food shortages, infrastructural problems and a low production culture that became especially obvious by the 1980s. This paper demonstrates the controversy of Soviet industrial food-making: strong beliefs in food science as the trigger for increasing living standards co-existed with backward industrial infrastructures which left ‘modern food’ a matter of experiment rather than real production. This reveals a pivotal problem in the Soviet economy, where intensive research met insufficient infrastructures for implementation.
Polynomials over structured grids
Authors: Nica Bogdan
Published: October 2022

We study multivariate polynomials over ‘structured’ grids. Firstly, we propose an interpretation as to what it means for a finite subset of a field to be structured; we do so by means of a numerical parameter, the nullity. We then extend several results – notably, the Combinatorial Nullstellensatz and the Coefficient Theorem – to polynomials over structured grids. The main point is that the structure of a grid allows the degree constraints on polynomials to be relaxed.
A rise and fall of a Chaghadaid community: demographic growth and crisis in ‘late-medieval’ Semirech'ye (Zhetysu), circa 1248–1345
Authors: Slavin Philip
Published: October 2022

This article analyses long-term population dynamics—growth, decline, sex- and age-composition—in Chaghadaid-era Central Asia in the context of the ‘Late-medieval Crisis’. It is based on a unique dataset of 630 epitaphs from two East Syriac (‘Nestorian') graveyards in the Semirech'ye region (Northwest Tian Shan, North Kyrgyzstan), boosted by archaeological and osteological evidence from the same graveyards. This epigraphic corpus is truly unique in the sense that this is the only surviving data that allow the undertaking of such a quantitative reconstruction of pre-modern Central Asian demography. A close analysis of the corpus, based on the ‘excess mortality’ method, reveals rapid demographic growth between circa 1270 and 1330, despite frequent short-term mortality crises, caused, most likely, by a combination of environmental and political factors. The population growth came to a sudden halt because of a major plague outbreak in 1338–1339, killing about three-quarters of the local population, and initiating what was known as the Black Death of 1347–1353 in West Eurasia and North Africa. The analysis of sex and age ratios indicates that the local population regime was heavily male-dominated. The plague of 1338–1339 targeted primarily younger women, most likely due to pregnancy-related hazards; conversely, in other crisis years, adult males were more susceptible. The findings of the article are wrapped into the wider context of the ‘Late-medieval Crisis’.
Co-creating Danish cohousing
Authors: Andersen Michael Asgaard , Lyhne Mette Boisen
Published: October 2022

In this article, we explore how different kinds and varying degrees of co-creation have shaped cohousing in Denmark over the past half century. The first part of the article is concerned with how this is related to types of ownership and ways of establishing new communities; the second part to the role of the architect, arguing for more experimental and open processes; and the third part to resident mix and community life, which raises questions of diversity and the unfinished. The article concludes with a discussion of how the accumulated experiences may contribute to strengthening a sense of belonging and community in future cohousing during the processes of both construction and habitation.
Fear in disguise: defensive architecture and façade permeability in shaping the urban experience of Belfast’s public spaces
Authors: Abdelmonem Mohamed Gamal
Published: October 2022

This article investigates architectural responses to everyday sociospatial practices in public spaces in the postconflict urban landscape of Belfast, where public buildings and façades impact pedestrian flows and movement patterns in the public space. While the city has an extended history of vibrant public spaces and active urban life throughout the first half of the twentieth century, devastating memories of the so-called Troubles leave imprints of division across the city’s public spaces. Inscribed by memories of conflict and violence, ground floor façades are mainly solid, disengaging, and do not encourage fluid movement across their thresholds. This article argues that the architectural design of public buildings and spaces characterise attributes of a reciprocal reproduction of memories of fear. A comparative analysis of the architecture of four different public spaces in Belfast city centre highlights factors that inform the relationship between the building façades, ease of accessibility, and use of the public space.
Ketamine-assisted meaning-centered psychotherapy for a patient with severe suicidal behavior
Authors: Forcén Fernando Espí , Marengo Laura , Behn Maya
Published: October 2022

There is a current debate in society as to whether depression can be a terminal illness. Meaning-centered psychotherapy (MCP) and psychedelic medicines have both been shown to treat existential distress in palliative care settings. We are reporting the case of a patient for whom MCP combined with ketamine was an effective treatment for his recurrent and severe depressive disorder with suicidal ideation. His complex assessment and management of suicide (CAMS) scores improved significantly with this treatment modality. Ketamine is generally well tolerated and can enhance treatment outcomes in patients undergoing MCP.
Genetic diversity and marker trait association for yield attributing traits in accessions of common bean (Phaseolus vulgarisL.) in India
Authors: Gupta Chainika , Salgotra Romesh Kumar , Alvarez Venegas Raul , Mahajan Reetika , Koul Umang
Published: October 2022

Common bean (Phaseolus vulgarisL.) is a highly economically important crop worldwide and a particularly important source of protein and minerals for people in less developed countries. Improving yield is a vital objective to meet the increasing demand for food due to the expanding human population. The present study was undertaken to study the genetic architecture of agronomic traits of common bean in India, particularly in the north-western Himalayan region. Marker-trait association (MTA) analysis was performed in a population of 100 common bean accessions using polymorphic microsatellite markers.Population structure analysis based on SSR markers divided the accessions into three main subpopulations. Ten significant MTAs were found using general linear model (GLM) and mixed linear model (MLM) approaches. We found two markers i.e. BM142 and J04555 associated with 100 seed weight and pods per plant common in both the GLM and MLM approach markers. All the MTAs were considered as major MTAs contributing more than 25% phenotypic variation. The significant quantitative trait loci identified in this study could be used in marker-assisted breeding to accelerate the genetic improvement of yield and development of high yielding common beans lines.
Influence of Bilingualism on Behavioral and Electrophysiological Parameters of Cognitive Control
Authors: Försterling Marlene , Hainke Laura , Redkina Anna , Sauseng Paul
Published: October 2022

Abstract: Bilingualism has been associated with better cognitive control as compared to monolingualism. However, the robustness of the respective findings is subject to a recent debate, and moderators should be taken into consideration. We reasoned that groups immersed in their second language should show a greater bilingual advantage in cognitive control as compared to non-immersed participants. Further, stimulus language (first or second language), word similarity in the two languages (similar or dissimilar), as well as congruency between ink and word were varied. Forty-five participants from three different language groups (Romance, Slavic, and German) conducted a Stroop task while EEG was recorded. Higher cognitive control demand was operationalized as (1) longer reaction times, (2) higher error rates, (3) stronger N400, (4) increased Late Positive Complex (LPC), and (5) stronger Frontal Midline Theta activity. The classical Stroop interference effect was replicated for all dependent variables. Contrary to expectation, participants immersed in their second language did not exhibit any inhibition advantage in the Stroop task. Moreover, higher script similarity between first and second languages led to faster response times in general. Results are discussed in light of the current debate on the existence of a bilingual advantage in cognitive control.
Single Session Anodal Transcranial Direct Current Stimulation on	Different Cortical Areas
Authors: Erdoğan Ezgi Tuna , Küçük Zeynep , Eskikurt Gökçer , Kurt Adnan , Ermutlu Numan , Karamürsel Sacit
Published: October 2022

Abstract: Transcranial direct current stimulation (tDCS) studies in healthy volunteers have shown conflicting results in terms of modulation in pain thresholds. The aim of this study was to investigate how single session anodal tDCS and modulated tDCS (mtDCS) of distinct cortical areas affected pain and perception thresholds in healthy participants. Five different stimulation conditions were applied at different cortical sites to 20 healthy volunteers to investigate the effects of tDCS and mtDCS (20 Hz) on pain and perception thresholds. TDCS over the motor cortex (M1), mtDCS over the motor cortex, tDCS over the dorsolateral prefrontal cortex (DLPFC), mtDCS of the DLPFC, and mtDCS over the occipital cortex were the stimulation conditions. All of the stimulations were anodal. The stimulations were given in a randomized order at 20-minute intervals. For comparison, electrical pain and perception thresholds were obtained from the right middle finger before and during the tDCS. After each measurement, participants were asked to give a score to their pain. In repeated measures analysis of variance (RM-ANOVA) test, the Condition × Time interaction showed no significant influence on changes in pain, perception thresholds, and pain scores ( p = .48, p = .89, and p = .50, respectively). However, regardless of the condition types, there was a significant difference in pain and perceptual thresholds during tDCS ( p = .01, p = .025, respectively). Our findings did not support difference in pain and perception modulation by a single session anodal tDCS over M1 and DLPFC compared to the occipital cortex in healthy volunteers. The increase in all thresholds during tDCS, irrespective of conditions, and peripheral sensations, including an active control group, taken together, suggest a placebo effect of active tDCS. Future studies about pain and perception in healthy subjects should consider the level of experimental pain and a strong placebo effect.