bluuebunny/crossref_metadata_2025 huggingface dataset:
A fotoantropometria como método de análise facial para estimativa de idade forense: revisão sistemática
Authors: Alves Yanka Barbosa , Falcão Tainá Nascimento , Fernandes Loyse Martorano , Nóbrega Johnys Berton Medeiros da , Lima Laíse Nascimento Correia , Machado Carlos Eduardo Palhares , Santiago Bianca Marques
Published: March 2021

O crescimento exponencial de crimes na internet, como a pedofilia, demanda muitas vezes a estimativa da idade a partir das imagens faciais dos indivíduos envolvidos. O objetivo desse estudo foi avaliar a aplicabilidade do método da fotoantropometria para estimativa de idade com fins forenses por meio de uma revisão sistemática. Realizaram-se buscas nas bases PUBMED, SCOPUS, The Cochrane Library, Web of Science, LILACS, CAPES e SIGLE, utilizando MeSH e termos livres com base na estratégia PICO (P: população; I: intervenção; C: comparação; e O: desfecho). Incluíram-se estudos que avaliaram imagens de indivíduos por fotoantropometria para estimativa de idade forense. Procedeu-se extração dos dados e avaliação da qualidade metodológica (QUADAS-2). De 2809 artigos identificados, 37 foram selecionados inicialmente por abordar análise facial através de fotoantropometria. Após leitura na íntegra, identificou-se que 9 estudos que utilizaram o método para estimativa de idade. Com amostra proveniente de 9 nacionalidades diferentes, 5 artigos tiveram suas marcações fotoantropométricas realizadas manualmente, enquanto 4 foram automatizadas. Todos os estudos tiveram agrupamentos de idade próprios para determinação das mesmas, não havendo coincidências entre eles. O método da fotoantropometria foi considerado eficaz para estimativa de idade em 5 artigos, enquanto 4 reportam que mais estudos são necessários para minimizar erros. Somente 3 estudos apresentaram baixo risco de viés por utilizarem padrão de referência aplicável e confiável. A fotoantropometria apresenta aplicabilidade limitada na estimativa de idade forense, havendo evidência questionável acerca de seu uso, devido aos riscos de viés presentes nos estudos.
PALEOMORFOGENESIS BENTANG ALAM KOMPLEKS GUNUNG IJO, KULONPROGO
Authors: Nugrahini Rr. Amara , Hartono Hill Gendoet , Listyani R.A. T.
Published: March 2021

Studi geomorfologi daerah Kompleks Gunung Ijo perlu dilakukan untuk memahami geomorfologi masa lampau. Maksud penelitian adalah mengidentifikasi karakteristik geomorfologi dengan tujuan untuk mendapatkan pemahaman tentang paleomorfogenesis Gunung Ijo. Penelitian dilakukan dengan metode observasi geomorfologi di lapangan dan dibantu dengan analisis petrografi batuan. Gunung Ijo merupakan salah satu gunungapi tua yang membentuk Perbukitan Kulon Progo. Kompleks Gunung Ijo disusun oleh dominasi batuan beku serta batuan gunung api yang berupa lava koheren dan piroklastika, selain oleh batuan sedimen yang berupa batugamping. Kompleks G. Ijo membentuk bentang alam sisa tubuh gunung api purba. Morfologi yang tersisa ini diinterpretasikan sebagai bagian dari tubuh gunungapi purba pada fasies pusat dan proksimal.Kata kunci: G. Ijo, paleomorfogenesis, fasies gunungapi, bentang alam sisa
IDENTIFIKASI RONGGA MENGGUNAKAN METODE GEOLISTRIK KONFIGURASI DIPOLE-DIPOLE DAERAH NUSAKAMBANGAN CILACAP JAWA TENGAH
Authors: Andi  , Setiahadiwibowo Ajimas Pascaning
Published: March 2021

Identifikasi rongga di pulau Nusakambangan menggunakan metode geolistrik konfigurasi dipole-dipole telah dilakukan. Metode ini digunakan untuk memetakan nilai resistivitas secara lateral pada masing-masing lintasan. Pengujian geolistrik tahanan jenis dilakukan dengan menggunakan 4 lintasan dengan panjang bentangan 200 - 400 m. Hasil penelitian menunjukan adanya beberapa pola yang diinterpretasikan sebagai rongga di sepanjang lintasan yang di survei. Pola- pola tersebut yaitu (i) tiga pola klosur pada lintasan A dengan rentang resistivitas lebih dari 4000 ohmmeter, (ii) dua pola klosur pada lintasan B dengan rentang resistivitas lebih dari 10000 ohmmeter (iii) satu pola klosur pada lintasan C dengan rentang resistivitas lebih dari 10000 ohmmeter, dan (iv) dua pola klosur pada lintasan D dengan rentang resistivitas lebih dari 2000 ohmmeter. Hasil penelitian bisa menjadi gambaran untuk menandai lokasi-lokasi di permukaan yang rawan atau berpotensi terjadinya bencana amblesan/sinkhole.Kata Kunci: Dipole-dipole; Geolistrik; Resistivitas; Rongga .
PEMBUATAN WEB BASE SIMULATOR PLANT DENGAN PLC UNTUK KULIAH PRAKTIKUM SECARA DARING
Authors: Muhamad Anda Falahuddin  , ARMAN MUHAMMAD , Farash Arya Pratama  , Muhammad Rasyid Ali
Published: March 2021

Kondisi pandemic COVID-19 membuat kegiatan perkuliahan bergeser menjadi kuliah secara daring. Untuk kegiatan perkuliahan teori relative lebih mudah dilakukan, namun untuk kegiatan praktek diperlukan sarana untuk dalam bentuk suatu simulator plant. Pada penelitian ini buat suatu simulator plant berbasis web dengan menggunakan PLC Logo! Siemens. Tahap awal dari proses ini adalah pembuatan simulator dengan menggunakan PLC Logo! secara local. Simulator ini menggambar hubungan sejumlah input digital dan output digital, yang diprogram menggunakan perangkat lunak Logo! Softcomfort. Selanjutnya dikembangkan web base simulator dengan menggunakan perangkat web editor, sehingga simulator yang dibuat dapat diakses melalui akses web oleh mahasiswa. Pengujian yang dilakukan meliputi pengujian fungsional secara local dan pengujian akses perangkat secara daring oleh mahasiswa. Hasil Pengujian menunjukkan bahwa web base simulator plan ini dapat digunakan sebagai alat bantu praktikum daring dalam lingkungan terbatas.

Kata kunci: Web server, simulator, PLC
EFEKTIVITAS SOFTWARE SPLIT DESKTOP PADA PELEDAKAN
Authors: Sutrisno Agung Dwi
Published: March 2021

Fragmentasi batuan sangat berpengaruh terhadap produktivitas penambangan yang menggunakan peledakan sebagai salah satu metode pembongkaran batuan. Tujuan penelitian ini adalah mengkaji efektivitas penggunaan Software Split Desktop pada analisis fragmentasi batuan hasil peledakan. Pendekatan penelitian ini menggunakan metode pengamatan di lapangan dan laboratorium. Data primer diambil langsung di lapangan dan data sekunder dari perusahaan. Data primer berupa foto fragmentasi hasil peledakan yang dianalisis ukuran fragmentasinya menggunakan Software Split Desktop. Hasilnya, Software Split Desktop dapat menganalisis dengan cepat fragmentasi batuan dengan media foto hasil peledakan. Analisis yang cepat ini dapat segera digunakan untuk mengubah desain peledakan berikutnya, sehingga menjadi lebih efektif.Kata kunci: batubara, konturing, kriging, trianggulasi.
CLINICAL RESULTS OF MOSAICPLASTY IN THE OSTEOCARTILAGINOUS LESIONS OF THE KNEE
Authors: Rădulescu D. M. , Cocor Cristina , Rădulescu A. R.
Published: March 2021

The aim of this paper is to evaluate the medium term postoperative results of mosaicplasty depending on the location and dimension of the cartilaginous defect. This study used the database of University Emergency Hospital Bucharest, the Department of Orthopedics and Traumatology, which recorded a number of 112 mosaicplasties between 2006 and 2012. Mosaicplasty is a surgical technique of autologous transplantation of some osteocartilaginous cylinders from a non-bearing donor area to the area of the cartilaginous defect in the knee. The postoperative functional evaluation was performed by means of the International Knee Documentation Committee (IKDC) score 6 months after the intervention, compared to the IKDC score prior to surgery and Lysholm and International Cartilage Repair Society (ICRS) score for the evaluation of the cartilage one year after surgery. The greatest rise in the IKDC score 6 months after surgery was recorded for the patients with posttraumatic osteocartilaginous lesions. In terms of the quality of recovery of the articular cartilage, assessed by means of the ICRS score, the best results were obtained for small lesions with traumatic etiology located at the medial femoral condyle. The technique of mosaicplasty represents an outstanding solution for patients with non-degenerative osteo-cartilaginous lesions. However, the result of surgery depends on the etiology, location and dimension of the osteochondral defect, as well as on the surgeon’s experience and patient’s compliance with the treatment.
PREDICTIVE FACTORS FOR THE RESPONSE OF LOCAL AND ADVANCED RECTAL CANCER TO NEOADJUVANT RADIOCHEMOTHERAPY
Authors: Constantin Ana
Published: March 2021

Rectal cancer is an aggressive form of cancer whose treatment follows the next steps: neoadjuvant therapy, surgical excision, and postoperative therapy.Currently, they are trying to identify some predictive factors related to the response to neoadjuvant therapy. Among these factors there are: the characteristics of the tumor - according to the TNM classification; the character of the tumor - by monitoring Ki67 protein and mRNA, by thymidylate synthase and EGF determination, as well as independent traits such as age and sex. To the extent in which the factors mentioned anticipate the uselessness of the neoadjuvant therapy, it can be excluded from the treatment plan, which implicitly implies benefits such as reduction of the time interval elapsed until the surgical intervention, and also reduction in the duration and cost of treatment. There are also short-term benefits. The patient will no longer face deterioration in his psychological status and decreased immunity, or other adverse effects of radiochemotherapy.
FREE PERITONEAL FLUID IN TRAUMA PATIENTS: THE PARADIGM SHIFT
Authors: Negoi I. , Păun S. , Hostiuc S. , Stoica B. , Tănase I. , Beuran M.
Published: March 2021

Trauma surgeons are confronted nowadays with various abdominal injuries, with a more and more increased severity, secondary to urban violence and traffic related accidents. We aim to better define the prognostic value of post-traumatic hemoperitoneum (PTH) in the nowadays era of nonoperative management of abdominal lesions, and to correlate it with the current pattern of traumatic injuries. Retrospective study of patients admitted during 24 months. Selections criteria: (1) Traumatic injury; (2) Free peritoneal fluid on preoperative imaging; (3) Surgical exploration of the abdomen. Setting: A level I trauma center. Results: There were 64 patients, with two peak frequencies between 18-35 and 50-70 years old. Abdominal wall ecchymoses were found in 36 (55%) of cases. Out of 64 cases 37 (58.7%) were transportation related, 12 (19%) caused by human aggression and 10 (16.9%) by falls. According to the Trauma Score (TS) there were 50 (78.2%) cases with TS between 14-16, 9 (17.2%) between 10 –13 and 3 (4.8%) with TS <9. More frequent extraabdominal associated lesions were: head injuries – 38 (58.5%), thoracic trauma – 34 (52.3%), orthopedic injuries – 24 (36.9%). Diagnostic peritoneal lavage was performed in 5 (7.8%) cases. FAST has a sensibility of 70.21% and CT scan a sensibility of 100%. Most frequent injured abdominal organs were the spleen – 36 (56.25%), liver 17 (26.56%) and mesentery 14 (21.87%). Laparotomy was performed in 59 (92.2%) of cases, laparoscopy in 2 (3.1%) of cases and conversion to open surgery in 3 (4.7%) cases. Mortality was 23.43%. We observed several predictive factors for mortality on univariate analysis: haemoglobin < 8g/dl (p=0.02), haematocrits < 25% (p=0.01), hemoperitoneum > 1500 ml (p=0.04), colonic trauma (p=0.001), head (p=0.01) and thoracic injuries (p=0.04). Dedicated trauma surgeons should balance between trauma kinetics details, patients’ clinical examination, and diagnostic workup, in an effort to decrease morbidity and mortality secondary to missed injuries or unnecessary laparotomies.
DIABETES MELLITUS IS A NEGATIVE PROGNOSTIC FACTOR FOR ACUTE PANCREATITIS
Authors: Lică M. , Negoi I. , Mircescu G. , Stoica B. , Beuran M.
Published: March 2021

Type 2 Diabetes Mellitus (T2DM) and Acute Pancreatitis (AP) are usually perceived as two different types of pancreatic pathology. Even though, there is a growing evidence that there is a mutual influence between these two diseases.Our aim is to assess the risk of patients with T2DM to develop AP according to the three grades of severity of Atlanta 2012 Classification of AP. We consider the hypotheses that patients with T2DM have a greater risk of more severe forms of AP because they have a reduced resistance for acute illnesses. We analyzed all consecutive cases of Acute Pancreatitis admitted to Surgical Clinic during the entire year of 2014.
MULTIPLE SURGERIES AND LONG-TERM ENDOCRINE FOLLOW-UP IN MEN 2A SYNDROME
Authors: Baloescu Rene , Carsote Mara , Albu Simona Elena , Valea Ana
Published: March 2021

MEN2A (Multiple Endocrine Neoplasia type 2) syndrome, an autosomal dominant condition, requires multiple surgeries in order to prevent or treat different tumours that are related to RET proto-oncogene mutations. Early intervention is most useful in cases with prior genetic confirmation. This is a case report presenting a long medical history of a female suffering of MEN2A syndrome. A 44-year-old woman, with a large family history of different endocrine cancers but no gene testing, is diagnosed at the age of 31 with a thyroid nodule of 1.7 centimeters (cm) which is removed by a partial thyroidectomy. Medullary thyroid cancer (MTC) is confirmed and calcitonin is found high. Total thyroidectomy is performed without consecutive normalization of calcitonin and secondary persistent post-operatory hypoparathyroidism. 6 months later a right laparoscopic adrenalectomy is performed for a pheochromocytoma (Pheo) of 5.2 cm. Despite normal levels of metanephrines and normetanephrines, a left adrenal tumor of 1.5 cm is discovered one year later. One decade later, the blood calcitonin progressively increased and 41 lymph nodes from latero-cervical areas and central neck compartment were removed. 14 of them had MTC metastases. 8 months later, typical endocrine profile suggested a Pheo and laparoscopic left adrenalectomy is performed with chronic adrenal insufficiency needing lifelong hydrocortisone and fludrocortisone replacements. The MEN2A syndrome-related multiple surgeries are correlated with long-term endocrine follow-up in challenging cases such as ours requiring a multi-disciplinary approach. The lack of gene mutation identification during childhood or at close relatives delays the diagnosis and thus the potential curative surgical removal of the thyroid and adrenal tumours with a more severe prognosis.
TENSION GASTROTHORAX: OCCULT CHILDHOOD DIAPHRAGMATIC INJURY PRESENTING AS ACUTE EMERGENCY IN PREGNANCY
Authors: Hussaina Syed Shamshad , Khana Asif , Yawarb Farhana , Alia Sardar , Skainia Muhammad Al , Hummadia Abdulelah
Published: March 2021

We present a case of tension gastrothorax in a 27-year-old primigravida with the complaints ofrespiratory distress. She was hypoxic and tachycardiac. The left thorax was resonant to percussion andhad no air entry. Chest X-ray was not helpful to reach the diagnosis. Later on, the tracheal deviationwas noted and thoracostomy was done. The patient aborted overnight. Greenish fluid in the chestdrain led to an investigation with computed tomography which revealed massive viscerothorax. Reviewof her history revealed that she had a blunt abdominal injury as a child. Laparotomy confirmed theabove findings along with a gastric perforation. Diaphragm and stomach were repaired,gastropexy and caecopexy was done. Occult diaphragmatic injury can complicate the pregnancy.High intra-abdominal pressure during the pregnancy can push much of abdominal contentsthrough the diaphragmatic defect. Creation of angulation at gastroesophageal junction acts as aone-way valve and thus leads to progressive dilation of the stomach, resulting in tensiongastrothorax.
MALIGNIZED BRANCHIAL CYST OR CERVICAL METASTATIC ADENOPATHY WITH PRIMARY TUMOR IN A TONSILLAR HIDDEN CARCINOMA?
Authors: Vrînceanu Daniela , Dumitru M. , Ardeleanu Carmen Maria
Published: March 2021

Cancer of occult origin is defined as a group of primary tumors with metastatic determinations, most commonly lymph nodes for which diagnostic algorithms fail to identify the place of origin of the primary tumor at the time of positive metastasis diagnosis. Squamous cell carcinoma with a truly unknown primary office is a relatively rare entity in the region of the head and neck. Retrospective studies suggest that it accounts for 1-3% of new cases of squamous cell carcinoma of the head and neck. We will present the clinical case of a 76-year-old patient with metastatic left-cervical cystic metastatic adenopathy, initially interpreted as a malignant branchial cyst. Discrepancies in histopathological examination, imaging and clinical examination delayed the performance of adjuvant radiotherapy. We will present details of diagnosis and evolution of the case. The results of the systematic literature review suggest that palatal tonsillectomy has a high overall rate of detection of subclinical primary tumors. Given the significant number of bilateral / contralateral occult tonsil tumors reported in the specialty literature, bilateral tonsillectomy should be considered in determining the diagnosis of squamous cell carcinoma patients of unknown primary origin in the head and neck. Cervical lymph node metastasis with unknown primary tumor remains a difficult topic for head and neck oncology. Most diagnostic and treatment protocols recommend unilateral or bilateral tonsillectomy, with an increased chance of finding an occult tumor in the palatine, unilateral or bilateral tonsils. In the presence of a cystic cervical lymph node metastasis, the first location should be considered as the primary tumor site must be the palatine tonsil.
Case Report: Persistent Primitive Hypoglossal Artery Accompanied by a Basilar Bifurcation Aneurysm Treated by Y-Stent-Assisted Coil Embolization
Authors: Zhang Longhui , Chen Xiheng , Jia Luqiong , Dong Linggen , Wang Jiejun , Liu Peng , Lv Ming
Published: March 2021

Successful embolization of a basilar bifurcation aneurysm associated with a persistent primitive hypoglossal artery (PPHA) using Y-stent-assisted coiling.
Baseline Differences in Anxiety Affect Attention and tDCS-Mediated Learning
Authors: Gibson Benjamin C. , Heinrich Melissa , Mullins Teagan S. , Yu Alfred B. , Hansberger Jeffrey T. , Clark Vincent P.
Published: March 2021

Variable responses to transcranial direct current stimulation (tDCS) protocols across individuals are widely reported, but the reasons behind this variation are unclear. This includes tDCS protocols meant to improve attention. Attentional control is impacted by top-down and bottom-up processes, and this relationship is affected by state characteristics such as anxiety. According to Attentional Control Theory, anxiety biases attention towards bottom-up and stimulus-driven processing. The goal of this study was to explore the extent to which differences in state anxiety and related measures affect visual attention and category learning, both with and without the influence of tDCS. Using discovery learning, participants were trained to classify pictures of European streets into two categories while receiving 30 min of 2.0 mA anodal, cathodal, or sham tDCS over the rVLPFC. The pictures were classifiable according to two separate rules, one stimulus and one hypothesis-driven. The Remote Associates Test (RAT), Profile of Mood States, and Attention Networks Task (ANT) were used to understand the effects of individual differences at baseline on subsequent tDCS-mediated learning. Multinomial logistic regression was fit to predict rule learning based on the baseline measures, with subjects classified according to whether they used the stimulus-driven or hypothesis-driven rule to classify the pictures. The overall model showed a classification accuracy of 74.1%. The type of tDCS stimulation applied, attentional orienting score, and self-reported mood were significant predictors of different categories of rule learning. These results indicate that anxiety can influence the quality of subjects’ attention at the onset of the task and that these attentional differences can influence tDCS-mediated category learning during the rapid assessment of visual scenes. These findings have implications for understanding the complex interactions that give rise to the variability in response to tDCS.
Patterns and Treatment Strategies of Osimertinib Resistance in T790M-Positive Non-Small Cell Lung Cancer: A Pooled Analysis
Authors: Wang Chunsheng , Zhao Kewei , Hu Shanliang , Li Minghuan , Song Yipeng
Published: March 2021

Introduction

Osimertinib resistance is inevitable. The purpose of this study was to explore the predictive value of pretreatment clinical characteristics in T790M-positive non-small cell lung cancer NSCLC patients for the resistance pattern of osimertinib during tumor progression as well as the treatment strategy.

Methods

We performed a literature search in the NCBI PubMed database to identify relevant articles and completed a pooled analysis based on 29 related published studies. The relationship between clinical characteristics, EGFR mutation type, previous treatment history and the gene mutation pattern at resistance to osimertinib was analyzed.

Results

A total of 38 patients were included in the pooled analysis. Patients with an initial epidermal growth factor receptor EGFR mutation status of 19 deletions were more likely to have T790M loss (HR: 12.187, 95% CI: 2.186–67.945, p = 0.004). Patients with an initial EGFR mutation of L858R were more likely to have C797S mutations (HR: 0.063, 95% CI: 0.011–0.377, p = 0.002). The other factors (age, gender, ethnicity, smoking history, previous EGFR-TKI targeted therapy history, history of radiotherapy and chemotherapy) were not associated with the resistance pattern of osimertinib (all p > 0.05).

Conclusions

The type of EFGR mutation in T790M-positive NSCLC patients prior to treatment can predict the resistance pattern to osimertinib. This finding plays a vital role and theoretical basis in guiding clinicians to formulate treatment strategies at the early stage of treatment and rationally combine drugs to overcome EGFR-TKI resistance.
The Diminishing Importance of Primary Site Identification in Cancer of Unknown Primary: A Canadian Single-Center Experience
Authors: Wong Boaz , Vickers Michael M. , Wheatley-Price Paul
Published: March 2021

Background

Cancer of unknown primary (CUP) describes patients with metastatic disease without an identified primary tumor site. Successful diagnosis and treatment of these patients remains difficult. Published guidelines on CUP have highlighted “favorable” subtype groups. We investigated a series of CUP patients to review adherence to guidelines, and identification of primary cancers or “favorable” subtypes.

Methods

Patients with histologically confirmed CUP at an academic institution from 2012 to 2018 were identified. Patient demographics, tumor presentation, diagnostic work-up and treatment information were retrospectively collected from electronic data records for descriptive analysis and compared to published clinical guidelines. The primary endpoint was the proportion of patients where the primary site was identified. Multivariable logistic regression models were used to identify factors associated with primary site identification. Kaplan-Meier survival curves were used to determine factors associated with poorer OS.

Results

Three hundred and five patients were included with a median follow-up time of 4.3 months. Primary tumor sites were identified in 109 patients (37.5%), which was most commonly lung cancer (33%). Statistical analyses did not identify any demographic or initial presentation factors associated with identifying the primary or not. More diagnostic tests did not increase the likelihood of primary site identification (P=0.44). Patients with an identified primary did not have longer OS than other patients (median 5.2 months vs. 4.7 months, P=0.47). 57 patients (18.7%) who had a defined “favorable” subtype experienced superior OS (36.6 months vs. 3.8 months; P<0.0001). Further, patients with good prognostic status who followed published treatment guidelines had longer OS (17.6 months vs. 13.2 months; P=0.04).

Conclusions

CUP remains a difficult cancer to diagnose and treat. These results suggest identifying the primary has less impact than anticipated, but particular efforts to identify patients with “favorable” subtypes of CUP is important prognostically.
Heterogeneous Recommendations for School Attendance in Children With Chronic Kidney Diseases During the COVID-19 Pandemic in Europe
Authors: Schild Raphael , Hopf Luke , Loos Sebastian , Oh Jun , Levtchenko Elena
Published: March 2021

Introduction: After worldwide closures due to the COVID-19 pandemic, schools have reopened in most European countries in late 2020. Consequently, for children with chronic diseases the risks of COVID-19 have to be weighed against the long-time risks of missing school.

Methods: To evaluate the impact of chronic diseases on school attendance for children in Europe during the COVID-19 pandemic we conducted a survey among members of the European Society for Pediatric Nephrology (ESPN) between September and November 2020. We asked for current forms of schooling, the existence of national guidelines, parental concerns, and the pediatric nephrologists recommendations for school attendance for specific virtual patients with chronic kidney disease (CKD).

Results: Recommendations varied widely among pediatric nephrologists. A minority stated that specific recommendations for COVID-19 risk in children with kidney diseases existed in their country from local health authorities (9 of 29 countries; 31%) and/or national pediatric nephrology societies (9 of 29 countries; 31%). Over 90% of physicians have experienced parents keeping their children out of school against medical advice of their health providers and about 50% have experienced their patients being refused by school authorities. Consequently, 25% of all pediatric nephrologists estimated that more than 10% of their patients will not attend school regularly.

Conclusion: COVID-19 causes educational deficits in the already vulnerable population of children with CKD. As the evidence for the course of COVID-19 in children with chronic diseases grows, rapidly adapted recommendations from pediatric societies could help reduce uncertainty among doctors, patients, and parents.
Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis
Authors: Crespo-Facorro Benedicto , Ruiz-Veguilla Miguel , Vázquez-Bourgon Javier , Sánchez-Hidalgo Ana C. , Garrido-Torres Nathalia , Cisneros Jose M. , Prieto Carlos , Sainz Jesus
Published: March 2021

Background: Antipsychotics modulate expression of inflammatory cytokines and inducible inflammatory enzymes. Elopiprazole (a phenylpiperazine antipsychotic drug in phase 1) has been characterized as a therapeutic drug to treat SARS-CoV-2 infection in a repurposing study. We aim to investigate the potential effects of aripiprazole (an FDA approved phenylpiperazine) on COVID-19-related immunological parameters.

Methods: Differential gene expression profiles of non-COVID-19 vs. COVID-19 RNA-Seq samples (CRA002390 project in GSA database) and drug-naïve patients with non-affective psychosis at baseline and after three months of aripiprazole treatment were identified. An integrative transcriptomic analyses of aripiprazole effects on differentially expressed genes in COVID-19 patients was performed.

Findings: 82 out the 377 genes (21.7%) with expression significantly altered by aripiprazole have also their expression altered in COVID-19 patients and in 93.9% of these genes their expression is reverted by aripiprazole. The number of common genes with expression altered in both analyses is significantly higher than expected (Fisher’s Exact Test, two tail; p value = 3.2e-11). 11 KEGG pathways were significantly enriched with genes with altered expression both in COVID-19 patients and aripiprazole medicated non-affective psychosis patients (p adj<0.05). The most significant pathways were associated to immune responses and mechanisms of hyperinflammation-driven pathology (i.e.,“inflammatory bowel disease (IBD)” (the most significant pathway with a p adj of 0.00021), “Th1 and Th2 cell differentiation” and “B cell receptor signaling pathway”) that have been also associated with COVID19 clinical outcome.

Interpretation: This exploratory investigation may provide further support to the notion that a protective effect is exerted by aripiprazole (phenylpiperazine) by modulating the expression of genes that have shown to be altered in COVID-19 patients. Along with many ongoing studies and clinical trials, repurposing available medications could be of use in countering SARS-CoV-2 infection, but require further studies and trials.
ETS Proto-Oncogene 1 Suppresses MicroRNA-128 Transcription to Promote Osteogenic Differentiation Through the HOXA13/β-Catenin Axis
Authors: Li Renyao , Dong Ying , Li Feipeng
Published: March 2021

ETS proto-oncogene 1 (ETS1) has been implicated in osteoporosis (OP), but the exact molecular mechanisms are complex. This work focuses on the impact of ETS1 on the osteogenic differentiation and the molecules involved. A mouse pre-osteoblast cell line MC3T3-E1 was used for in vitro experiments. ETS1 was upregulated during the process of osteogenic differentiation of MC3T3-E1 cells. Overexpression of ETS1 promoted expression of osteogenic markers, alkaline phosphate concentration, and calcareous accumulation in cells. ETS1 was found to specifically bind to miR-128 promoter to suppress its transcription, while miR-128 could target homeobox A13 (HOXA13). Therefore, ETS1 suppressed miR-128 transcription to upregulate HOXA13 expression. Overexpression of HOXA13 promoted the osteogenic differentiation ability of cells and increased the protein level of β-catenin. Either overexpression of miR-128 or downregulation of β-catenin by CWP232228, a β-catenin-specific antagonist, blocked the promoting roles of ETS1 in cells. To conclude, this study provided evidence that ETS1 suppresses miR-128 transcription to activate the following HOXA13/β-catenin axis, therefore promoting osteogenic differentiation ability of MC3T3-E1 cells. This finding may offer novel ideas for OP treatment.
Exploiting Genic Male Sterility in Rice: From Molecular Dissection to Breeding Applications
Authors: Abbas Adil , Yu Ping , Sun Lianping , Yang Zhengfu , Chen Daibo , Cheng Shihua , Cao Liyong
Published: March 2021

Rice (Oryza sativa L.) occupies a very salient and indispensable status among cereal crops, as its vast production is used to feed nearly half of the world’s population. Male sterile plants are the fundamental breeding materials needed for specific propagation in order to meet the elevated current food demands. The development of the rice varieties with desired traits has become the ultimate need of the time. Genic male sterility is a predominant system that is vastly deployed and exploited for crop improvement. Hence, the identification of new genetic elements and the cognizance of the underlying regulatory networks affecting male sterility in rice are crucial to harness heterosis and ensure global food security. Over the years, a variety of genomics studies have uncovered numerous mechanisms regulating male sterility in rice, which provided a deeper and wider understanding on the complex molecular basis of anther and pollen development. The recent advances in genomics and the emergence of multiple biotechnological methods have revolutionized the field of rice breeding. In this review, we have briefly documented the recent evolution, exploration, and exploitation of genic male sterility to the improvement of rice crop production. Furthermore, this review describes future perspectives with focus on state-of-the-art developments in the engineering of male sterility to overcome issues associated with male sterility-mediated rice breeding to address the current challenges. Finally, we provide our perspectives on diversified studies regarding the identification and characterization of genic male sterility genes, the development of new biotechnology-based male sterility systems, and their integrated applications for hybrid rice breeding.
Natural Bacteria Killers: How Bacteriophages Find and Eliminate Their Hosts
Authors: Gonzalez Floricel , Scharf Birgit E.
Published: March 2021

Bacteriophages, also called phages, are viruses that kill bacteria. They do not kill humans, animals, or plants. Phages only kill one or a few types of bacteria. Therefore, we can use phages that only kill disease-causing bacteria as medicines. Using phages ensures that the helpful bacteria stay alive. How do phages kill some bacteria and not others? They recognize specific parts of a bacterial cell. In this article, we describe how phages find their target bacteria even when other microbes are around.
Effect of the Ni/Al Ratio on the Performance of NiAl2O4 Spinel-Based Catalysts for Supercritical Methylcyclohexane Catalytic Cracking
Authors: Song Kyoung Ho , Jeong Soon Kwan , Jeong Byung Hun , Lee Kwan-Young , Kim Hak Joo
Published: March 2021

Supercritical methylcyclohexane cracking of NiAl2O4 spinel-based catalysts with varying Ni/Al deficiencies was investigated. Thus, catalysts with Ni content of 10–50 wt.% were prepared by typical co-precipitation methods. The calcined, reduced, and spent catalysts were characterized by X-ray diffraction, O2 temperature-programmed oxidation, NH3 temperature-programmed desorption, N2 physisorption, O2 chemisorption, scanning and transmission electron microscopy, and X-ray fluorescence. The performance and physicochemical properties of the reference stoichiometric Ni3Al7 catalyst differed significantly from those of the other catalysts. Indeed, the Ni-deficient Ni1Al9 catalyst led to the formation of large Ni particles (diameter: 20 nm) and abundant strong acid sites, without spinel structure formation, owing to the excess Al. These acted with sufficient environment and structure to form the coke precursor nickel carbide, resulting in a pressure drop within 17 min. On the other hand, the additional NiO linked to the NiAl2O4 spinel structure of the Al-deficient Ni5Al5 catalyst formed small crystals (10 nm), owing to the excess Ni, and displayed improved Ni dispersion. Thus, dehydrogenation proceeded effectively, thereby improving the resistance to coke formation. This catalytic behavior further demonstrated the remarkable activity and stability of this catalyst under mild conditions (450 °C and 4 Mpa).
Maximum Expiratory Flow of Children and Adolescents Living at Moderate Altitudes: Proposed Reference Values
Authors: Cossio-Bolaños Marco , Vidal-Espinoza Rubén , Castelli Correia de Campos Luis Felipe , Urzua-Alul Luis , Fuentes-López José Damián , Sulla-Torres Jose , Andruske Cynthia Lee , Gomez-Campos Rossana
Published: March 2021

(1) Background: Spirometry is useful for diagnosing and monitoring many respiratory diseases. The objectives were: (a) compare maximum expiratory flow (MEF) values with those from international studies, (b) determine if MEF should be evaluated by chronological age and/or maturity, (c) develop reference norms for children, and adolescents. (2) Methods: A cross-sectional study was designed with 3900 subjects ages 6.0 and 17.9 years old. Weight, standing height, sitting height, and MEF were measured. Length of the lower limbs, body mass index (BMI), and age of peak height velocity growth (APHV) were calculated. (3) Results: Values for the curves (p50) for females of all ages from Spain and Italy were higher (92 to 382 (L/min)) than those for females from Arequipa (Peru). Curve values for males from Spain and Italy were greater [70 to 125 (L/min)] than the males studied. MEF values were similar to those of Chilean students ages 6 to 11. However, from 12 to 17 years old, values were lower in males (25 to 55 (L/min)) and in females (23.5 to 90 (L/min)). Correlations between chronological age and MEF in males were from (r = 0.68, R2 = 0.39) and in females from (r = 0.46, R2 = 0.21). Correlations between maturity (APHV) and MEF for males were from (r = 0.66, R2 = 0.44) and for females (r = 0.51, R2 = 0.26). Percentiles were calculated for chronological age and APHV. Conclusion: Differences occurred in MEF when compared with other geographical regions of the world. We determined that maturity may be a more effective indicator for analyzing MEF. Reference values were generated using chronological age and maturity.
Mechanical Properties of the Carbon Nanotube Modified Epoxy–Carbon Fiber Unidirectional Prepreg Laminates
Authors: Bakis Gökhan , Wendel Jan-Felix , Zeiler Rico , Aksit Alper , Häublein Markus , Demleitner Martin , Benra Jan , Forero Stefan , Schütz Walter , Altstädt Volker
Published: March 2021

The effect of plasma treatment of the multi-walled carbon nanotube (MWCNT) surface on the fracture toughness of an aerospace grade epoxy resin and its unidirectional (UD) carbon fiber prepreg laminates has attracted scientific interest. A prepreg route eliminates the possible risk of carbon nanotube filtration by unidirectional carbon fibers. X-ray photoelectron spectroscopy results suggested that oxygen atom concentration at the nanotube surface was increased from 0.9% to 3.7% after plasma modification of the carbon nanotubes. A low number (up to 0.5 wt.%) of MWCNTs was added to epoxy resin and their carbon fiber prepreg laminates. Transmission electron micrographs revealed that the plasma treatment resulted in a better dispersion and distribution of MWCNTs in the epoxy resin. Plasma-treated MWCNTs resulted in a more pronounced resistance to the crack propagation of epoxy resin. During the production of the reference and nanotube-modified prepregs, a comparable prepreg quality was achieved. Neat nanotubes agglomerated strongly in the resin-rich regions of laminates lowering the interlaminar fracture toughness under mode I and mode II loading. However, plasma-treated nanotubes were found mostly as single particles in the resin-rich regions of laminates promoting higher energy dissipation during crack propagation via a CNT pull-out mechanism.
Introduction to the Special Issue: Exploring Gender and Sikh Traditions
Authors: Jakobsh Doris R.
Published: March 2021

Gender analysis has not received a great deal of attention within Sikh Studies (Jakobsh 2003) [...]
Real-Time Prognostics of Engineered Systems under Time Varying External Conditions Based on the COX PHM and VARX Hybrid Approach
Authors: Zhu Hongmin
Published: March 2021

In spite of the development of the Prognostics and Health Management (PHM) during past decades, the reliability prognostics of engineered systems under time-varying external conditions still remains a challenge in such a field. When considering the challenge mentioned above, a hybrid method for predicting the reliability index and the Remaining Useful Life (RUL) of engineered systems under time-varying external conditions is proposed in this paper. The proposed method is competent in reflecting the influence of time-varying external conditions on the degradation behaviour of engineered systems. Based on a subset of the Commercial Modular Aero-Propulsion System Simulation (C-MAPSS) dataset as case studies, the Cox Proportional Hazards Model (Cox PHM) with time-varying covariates is utilised to generate the reliability indices of individual turbofan units. Afterwards, a Vector Autoregressive model with Exogenous variables (VARX) combined with pairwise Conditional Granger Causality (CGC) tests for sensor selections is defined to model the time-varying influence of sensor signals on the reliability indices of different units that have been previously generated by the Cox PHM with time-varying covariates. During the reliability prediction, the Fourier Grey Model (FGM) is employed with the time series models for long-term forecasting of the external conditions. The results show that the method that is proposed in this paper is competent for the RUL prediction as compared with baseline approaches.
INTERNET NEWS MEMES WITH POLITICAL OVERTONES IN THE PERCEPTION OF YOUNG PEOPLE
Authors:   Saint Petersburg State University., Gorbatov D. S. , Gurushkin P. Yu. ,   Saint Petersburg State University
Published: March 2021

The purpose of the empirical research described in the article was to study the range of judgments that characterize the social perception of the student youth of Internet news memes with political overtones. The research method was a focus group interview using the Microsoft Teams platform. The four groups included 28 undergraduate students of higher educational institutions of St. Petersburg. The results of the study characterize the attitude of students to attempts to impose political overtones on Internet news memes, reflect their opinions about the mistakes made by the authors, contain arguments about the reasons for the anonymity of the authors of memes, describe the range of views on the problem of the responsibility of the authors of memes for violations of laws. In addition, students ' perceptions about changes in Internet memes, in particular, news memes, in the future were revealed.
الدافعية الذاتية وعلاقتها بالأداء المتميز لدى العاملين في الجامعات الفلسطينية بالمحافظات الجنوبية
Authors: الدجني إياد علي , حمد محمد حسن
Published: March 2021

هدف البحث إلى الكشف عن العلاقة بين كل من الدافعية الذاتية والأداء المتميز للعاملين الإداريين بالجامعات الفلسطينية. ولتحقيق أهداف الدراسة استخدام الباحثان المنهج الوصفي التحليلي. وتكَوّن مجتمع الدراسة من (318) موظفاً وموظفة من الإداريين في الجامعتين (الجامعة الإسلامية، جامعة الأقصى)، وطبقت الاستبانة على عينة الدراسة التي بلغت (232) موظفاً وموظفة، حيث اختيرت عينة الدراسة بطريقة عشوائية طبقية. كما تم تحليل البيانات باستخدام الاختبارات الوصفية المناسبة والاختبارات الاستدلالية اللامعلمية.
أظهرت نتائج الدراسة أن درجة شعور العاملين بالدافعية الذاتية جاءت بنسبة مرتفعة جداً وبوزن نسبي (84.19%)؛ كما أظهرت النتائج أن درجة الأداء المتميز لديهم أيضاً جاء بنسبة مرتفعة جداً بوزن نسبي بلغ (83.6%)، أظهرت نتائج الدراسة أن هناك علاقة طردية قوية ذات دلالة إحصائية بين الدافعية الذاتية ومحاورها الثلاثة (الشعور الذاتي – الشعور بالملكية – القيم التنظيمية) والأداء المتميز لدى العاملين الإداريين في الجامعة الإسلامية وجامعة الأقصى.
وفي ضوء ما تم التوصل إليه من نتائج، أوصى الباحثان بضرورة العمل على تعميق الوعي بمفهوم الأداء المتميز لدى العاملين الإداريين وكذلك القيادات الإدارية بالجامعات الأكاديمية، وضرورة أن تبدي الجامعات الفلسطينية أهمية بالغة في علاج مشكلات العمل.
Pelestarian Budaya Jawa Oleh Sekolah Budaya Tunggulwulung di Kota Malang, Jawa Timur
Authors: Pebrianto Moh. , Hadi Nur
Published: March 2021

This study aims to describe the process of the formation of the Tunggulwulung School of Culture (SBT) in Malang and the form of Javanese cultural preservation carried out by the school of culture. This study uses a qualitative research approach. The process of extracting data was carried out by observation, interviews, and documentation, and literature study. The results showed that the Tunggulwulung School of Culture (SBT) was established to preserve the culture and artistic heritage of the ancestors, particularly Javanese culture and arts. The activities carried out at the Tunggulwulung School of Culture (SBT) include ngangsu kaweruh or conducting studies on cultural history and heritage arts (especially Javanese culture), and others. Based on the AGIL concept by Parsons, the Tunggulwulung School of Culture (SBT) can survive and develop until today due to four aspects. The first is an adaptation, the Tunggulwulung School of Culture (SBT) adapts by freeing people to participate in activities according to their interests and wishes, and free of charge. The second is goal achievement. The school has various activities that are used as a basis for achieving the goal, namely preserving Javanese culture. Then the integration is carried out through the formation of an organizational structure, as well as holding various activities and promotions. The last one is latency, the Tunggulwulung School of Culture (SBT) maintains patterns or systems through innovation in learning models, activities, and promotions.
Patologi Birokrasi Dalam Pengelolaan Tenaga Honorer Di Kabupaten Mamuju Tengah
Authors: Sampar Sampar
Published: March 2021

This study aims to examine and analyze the bureaucratic pathology model in the management of honorary staff in Central Mamuju. Some of the indicators used in this study include perceptions of managerial style, violation of legal norms, low knowledge and skills, dysfunctional behavior and internal situations in various government agencies. The research method used is qualitative by using interviews as a means of extracting secondary data. Information is obtained from local governments, namely the education office, regional civil service agencies, financial institutions, council secretariats, hospitals and honorary staff. The results showed that the management of honorary staff in Central Mamuju district still shows bureaucratic pathology. This is evident in the method of recruiting honorary staff, there are still some individuals who still practice nepotism towards the acceptance of honorary staff; the lack of discipline of honorary staff is part of the pathology of the bureaucracy. Furthermore, the discipline of honorary staff in several OPDs is still not effective; found data dissynchronization / administration mall. Data discrepancies between the SK data issued and the data on the amount of wages disbursed by regional finances; the potential for budget fattening due to the absence of data validation from financial institutions on the number of SKs in each OPD with the reality in the field. Several suggestions were given as input to correct deficiencies in the management of honorary staff in Central Mamuju District.
Kajian Indeks Resiko Bencana dengan Kesiapan Puskesmas dalam Managemen Bencana Kesehatan di Kota Jambi
Authors: Subandi Andi , Noerjoedianto Dwi
Published: March 2021

This study aims to see the service system during a health disaster in the city of Jambi, namely Tahtul Yaman Puskesmas, Tanjung Pinang Health Center, and Aurduri Health Center. The short-term target is to find organizational standards and the role of the puskesmas team in disasters. The research method used survey analytics to assess the roles and functions that were involved in the health disaster management system and to analyze the readiness of 3 health centers in the city of Jambi. From the results of this study, according to the application of the Minister of Health Regulation number 75 of 2019 at the Tahtul Yaman Puskesmas, the Tanjung Pinang Health Center, and the first Aurduri Health Center, it is obtained from (1) There is no clear program regarding disaster management in each cluster at the Puskesmas, ( 2) Rapid Health Assessment (RHA) has not been implemented in the event of a disaster, (3) The coordination flow for the Puskesmas already exists, namely through referrals to the Abdul Manap Regional General Hospital, Jambi City and the Jambi City Health Office.
Efektivitas Pilkada Serentak Tahun 2020 di Tengah Pandemi Covid-19 Indonesia
Authors: Prawitasari Ika , Erowati Dewi
Published: March 2021

This study examines effectiveness 2020 simultaneous regional elections in the midst of Covid-19 pandemic. In addition, indicators of success Pilkada are integrity organizers and public participation in exercising their voting rights. Therefore, looking at 2020 Pilkada which was held in midst Covid-19 pandemic is still an important discourse. This study used descriptive qualitative method. Data collection techniques use primary data obtained from webinars on local political democracy during pandemic and secondary data by citing books, journals, documents and printed media, as well as other supporting materials. The results showed that the 9 December 2020 Pilkada had several threats and opportunities, including; First, threat of high number of positive cases of Covid-19, limited time, process updating voter data, technical guidance for ad hoc administrators, logistical budgets, education and political outreach. Second, opportunities for technology and information as means of political education and political socialization. Third, organizing regional elections by using e-voting, being the right recommendation, seeing use of e-voting can preserve people's voting rights and inhibit spread of Covid-19.