bluuebunny/crossref_metadata_2025 huggingface dataset:
Highly Sensitive Electrochemical Pb(II) Sensors Based on MoS2/rGO Nanocomposites by Square Wave Voltammetry
Authors: Liu Shixing , Liu Xingnan , Xie Baozhu , Liu Xin , Hu Haibing
Published: July 2022

Currently, heavy metal ion contamination in water is becoming more and more common, especially Pb(II), which is a serious threat to human health. In this experiment, MoS2/rGO nanocomposites were used to modify glassy carbon electrodes and square wave voltammetry(SWV) electrochemical detection method was selected to detect trace Pb(II) in water. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) showed that MoS2 nanoparticles were uniformly distributed on the rGO films. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) showed that MoS2/rGO has higher sensitivity and conductivity. After determining the optimal experimental parameters, the MoS2/rGO modified glassy carbon electrodes exhibited high sensitivity (57.57 μA μM−1) and low limit of detection (0.060 μM) for Pb(II) as well as good interference resistance and stability.
Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth
Authors: Eckberg Kara , Weisser Ivan , Buttram Daniel , Somia Nikunj , Igarashi Peter , Aboudehen Karam S.
Published: July 2022

This study identified scAAV/DJ as effective in transducing epithelial cells of the metanephric organ culture (MOC). We used scAAV/DJ shRNA to knockdown Pvt1 in cystic MOCs derived from Pkd1-null embryos. Downregulation of Pvt1 reduced cyst growth and decreased levels of c-MYC protein. These data suggest that suppression of Pvt1 activity in autosomal dominant polycystic kidney disease might reduce cyst growth.
Assessing the Potential of the Strategic Formation of Urban Platoons for Shared Automated Vehicle Fleets
Authors: Wang Senlei , Correia Gonçalo Homem de Almeida , Lin Hai Xiang
Published: July 2022

This paper addresses the problem of studying the impacts of the strategic formation of platoons in automated mobility-on-demand (AMoD) systems in future cities. Forming platoons has the potential to improve traffic efficiency, resulting in reduced travel times and energy consumption. However, in the platoon formation phase, coordinating the vehicles at formation locations for forming a platoon may delay travelers. In order to assess these effects, an agent-based model has been developed to simulate an urban AMoD system in which vehicles travel between service points transporting passengers either forming or not forming platoons. A simulation study was performed on the road network of the city of The Hague, Netherlands, to assess the impact on traveling and energy usage by the strategic formation of platoons. Results show that forming platoons could save up to 9.6% of the system-wide energy consumption for the most efficient car model. However, this effect can vary significantly with the vehicle types and strategies used to form platoons. Findings suggest that, on average, forming platoons reduces the travel times for travelers even if they experience delays while waiting for a platoon to be formed. However, delays lead to longer travel times for the travelers with the platoon leaders, similar to what people experience while traveling in highly congested networks when platoon formation does not happen. Moreover, the platoon delay increases as the volume of AMoD requests decreases; in the case of an AMoD system serving only 20% of the commuter trips (by private cars in the case-study city), the average platoon delays experienced by these trips increase by 25%. We conclude that it is beneficial to form platoons to achieve energy and travel efficiency goals when the volume of AMoD requests is high.
A Magnetically Capsule Robot for Biomedical Application
Authors: Fu Qiang , Zhang Xi , Zhang Songyuan , Fan Chunliu , Cai Zhuocong , Wang Lili
Published: July 2022

Magnetic-driven capsule robot has been widely studied due to its advantages of safety and reliability. However, when doctors carry out clinical examination, the capsule robot cannot achieve the ideal control effect due to the influence of the external magnetic field air gap. This paper is based on the kinetic energy theorem, combined with the principle of spiral mechanism in mechanical design foundation to construct a calculation method of energy utilization and to improve the control effect of capsule robot, suitable for the human gastrointestinal tract precise control of capsule robot to perform a variety of complex tasks. By calculating the energy utilization rate of the capsule robot under the control of external magnetic field, the method can improve the energy utilization rate by improving the equation parameters, so that the capsule robot can run according to the doctor’s ideal performance in practical application. Based on the analysis of the magnetic driven screw capsule robot, the model of the utilization rate of the external magnetic field of the capsule robot is established, and the fluid simulation of the capsule robot is carried out by using the method of computational fluid dynamics. The simulation results and experimental results show that the control effect of capsule robot can be improved by calculating the energy utilization rate of the robot, which is of great significance to human clinical examination and treatment.
Identification of a Two-lncRNA Signature with Prognostic and Diagnostic Value for Hepatocellular Carcinoma
Authors: Liu Huiying , Zhu Jianjun , Guo Lingling , Zhang Hongjuan , Liu Shuxiong , Kou Xiaoxia
Published: July 2022

Background. Accumulating evidence has revealed the important role of long noncoding RNAs (lncRNA) in tumorigenesis and progression of hepatocellular carcinoma (HCC). This study aimed to identify potential lncRNAs that can serve as diagnostic and prognostic signatures for HCC. Methods. Expression profiling analysis was performed to identify differentially expressed lncRNAs (DElncRNA) between HCC and matched normal samples by integrating two independent microarray datasets. Functional Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were explored by Gene Set Variation Analysis. The prognostic and diagnostic models were developed based on two DElncRNAs. Real-time PCR was used to quantify the relative expressions of candidate lncRNAs. Results. Two robust DElncRNAs were identified and verified by quantitative PCR between HCC and matched normal samples. Function enrichment analysis revealed that they were associated with the wound healing process. The two lncRNAs were subsequently used to construct a prognostic risk model for HCC. Patients with high-risk scores estimated by the model showed a shorter survival time than low-risk patients (

P
<
0.001

). Besides, the two lncRNA-based HCC diagnostic models exhibited good performance in discriminating HCC from normal samples on both training and test sets. The values of area under the curve (AUC) for early (I–II) and late (III–IV) HCC detection were 0.88 and 0.93, respectively. Conclusions. The two wound healing-related DElncRNAs showed robust performance for HCC prognostic prediction and detection, implying their potential role as diagnostic and prognostic markers for HCC.
An Empirical Study on Coordinated Development between Ecological Environment and Regional Economy by Big Data Mathematical Model Analysis in Tibetan Area
Authors: Gao Li , Fu Liping , Tsai Sang-Bing
Published: July 2022

The cold and high altitude Tibetan area (hereinafter referred to as Tibetan area) is a special geographical area in western China. Whether the local economic development and EE (ecological environment) are coordinated or not directly affects the sustained and healthy economic and social development of the whole Tibetan area. Firstly, this paper discusses the relationship between economic growth and EE on the basis of existing related theoretical research. Then, 15 indicators of economic system and environmental system were selected, and the coupling degree model and coupling coordination degree model were constructed to quantitatively analyze the dynamic model of regional economic and EE coupling and coordinated development in Tibetan areas from 2010 to 2020. The research found that in the past 11 years, the comprehensive index of EE of four regions in Tibetan areas has changed from 0.5 to 0.6, and the comprehensive index of the economy of four regions in Tibetan areas has changed from 0.51 to 0.74. On the whole, the coordination degree and coordinated development degree of green development in Tibetan areas have changed at the same time compared with the years, and since 2016, both of them have had the same trend and both of them are beginning to develop in a good direction. Since 2017, the economic development has been relatively advanced, while the EE has lagged behind, showing a fluctuating state, while the level of coordinated development has been continuously improved. This study has certain reference value for promoting ecological protection and green development in Tibetan areas.
Entrepreneurship Behavior of Indigenous Fish Farmers in Eastern Chitwan, Nepal
Authors: Paudel Samyog , Regmi Reja , Subedi Milan , Karki Tilak
Published: July 2022

Aquaculture has great potential in the Terai region of Nepal due to the suitability of pond resources and government attempts to improve the fisheries sector. The majority of fish farmers in Chitwan belong to indigenous nationalities. Entrepreneurship skills help in uplifting local rural communities but due to the lack of attractiveness and economic production of fish in Chitwan, there is a higher chance of fish enterprise failure. Hence, an immediate need of assessing entrepreneurial behavior was felt and the study was carried out among indigenous fish farmers of Eastern Chitwan. For data collection, a questionnaire survey was conducted among eighty random respondents and a key informant interview was performed with expert farmers and fish scientists using the convergent parallel mixed method. Collected data were analyzed using SPSS version 22 and MS Excel. The entrepreneurial behavioral index (EBI) was calculated for each respondent, and it was assessed with various sociological and production factors. Average EBI was found among respondents. Most of the surveyed entrepreneurs have a low level of innovativeness, farming knowledge, and leadership while a medium level of motivation and decision‐making ability. From the t‐test, it was found that factors like AKC (Agriculture Knowledge Centre) visit, farming type, and organizational membership are significant but farmers’ gender, extension consultation, training, information source, education, and experience are nonsignificant with respondents’ entrepreneurship. Farmers who do commercial farming, visit AKC, and are members of social organizations have relatively more entrepreneurial behavioral indexes than other farmers. For the improvement of fish enterprises in the study area, training related to fisheries innovativeness, fish farming knowledge, and leadership is recommended through the collaboration of AKC and social organizations.
Voice Detection and Deep Learning Algorithms Application in Remote English Translation Classroom Monitoring
Authors: Niu Zhenyu
Published: July 2022

With the continuous development of cellular networks, the traffic from voice services increases gradually. The wireless sensor network (WSN) is a distributed network consisting of a large number of peripheral nodes distributed in the surveillance area. The nodes in the network complete it in a self-organizing form, and the sink node collects the data from each sensor node. When sending data, the nodes near the receiver will quickly run out of energy and cannot perform further transmission tasks. The resulting “power supply emptiness” problem has a great impact on network performance. Therefore, the power consumption of the network must be considered when designing the WSN routing algorithm. In order to effectively improve students’ academic performance and monitor students’ teaching conditions, the classroom remote monitoring system places two cameras in the university’s English translation classroom and uses technology to merge the information to execute the entire process. By recording the course, we can save the teacher’s classroom content and the student’s classroom performance and upload the recorded video in real time. In addition, the classroom remote monitoring system is a multiclient system, divided into teacher and student terminals. The user can log in, watch the video, and perform other necessary operations.
Removal of Toxic Metal Ions from Aqueous Solutions in Integrated Clay Adsorption and Electroflotation
Authors: Teixeira Raimundo Nonato Pereira , Neto Vicente Oliveira Sousa , Oliveira Juliene Tomé , Amorim Lucas Fontenele , Neto Eliezer Fares Abdala , de Quadros Melo Diego , Coutinho Henrique Douglas Melo , Kim Bonglee , Menezes Jorge Marcell Coelho , do Nascimento Ronaldo Ferreira
Published: July 2022

Most galvanic process industries treat their effluents by chemical precipitation methods. Such a method produces an amount of galvanic sludge that is often disposed of inappropriately to the environment, causing major environmental damage. These rejects present high concentrations of toxic metallic ions, such as copper (Cu(II)), lead (Pb(II)), nickel (Ni(II)), and cadmium (Cd(II)). Several alternatives have been proposed to contribute in a cheaper and efficient way to treat these effluents. This study aimed to describe the results obtained in the removal of the concentrations of Cu(II), Ni(II), Cd(II), and Pb(II) ions, present in an aqueous solution, by the use of a hybrid system combining the adsorption and electroflotation processes simultaneously. The adsorbent materials used were two Brazilian soil clays classified as sodium clay (SC) and ferric clay (FC). For the electroflotation process, aluminum, iron, and stainless-steel electrodes were used. The obtained data showed good efficiency in the removal of the four metallic ion concentrations. The best results presented a reduction in the concentration of Cu(II), Ni(II), Cd(II), and Pb(II) ions of 50.11%, 36.71%, 21.59%, and 23.43%, respectively, when it was used the hybrid system formed by the ferrous clay as adsorbent and the aluminum electrode for the electroflotation process.
Organic Photoelectric Materials and Organic Photoelectric Devices Based on Smart Image Sensors
Authors: Huang Gang
Published: July 2022

With the development of the times in recent years, people’s requirements for vision are no longer limited to the original foundation. As the core of research in this field, organic electroluminescence has paid great attention to the research points in the application of organic optoelectronic materials and devices in the world. From the relevant scientific research results in recent years, for example, organic light-emitting diodes can be used in flat-panel displays and solid-state lighting, organic photovoltaic cells can be used as a clean and renewable energy source to effectively alleviate the current energy needs of society, and organic storage, sensors, and so on show great promise for application. It can be seen that the research of organic optoelectronic materials and their devices will be the core hot spot of future new energy research. In the past, traditional organic optoelectronic materials are updated through the regulation strategy of covalent modification of the molecular structure. In recent years, new effective methods have been obtained to regulate the properties of excited states through physical stimulation (such as mechanical force, temperature, electric field, and magnetic field). The type of research experiment in this paper is based on the current hot smart image sensor, with the addition of organic complexes of mononuclear metal platinum and iridium metal and the organic optoelectronic device in the form of host and guest doping. The experimental results show that using PVK without energy transfer, polyvinyl carbazole (PVK) had been widely used as blue luminescent material and hole transport layer in electroluminescent device research. Simple mononuclear platinum and iridium metal complexes cannot obtain white light. For OPV devices, by selecting the correct solvent to control the bulk heterojunction, it exhibits better photovoltaic performance. Solvents play an important role in phase separation. In organic solar cells (OPV) consisting of an electron donor (D) and an acceptor (A), optimizing the D-A interface produces efficient charge separation, effectively separating excitons at the D-A interface and forming continuous electron and hole transport channels, and effective charge transport between electrodes plays a positive role.
Effect of PCI Standardized Telephone Follow-Up Service Mode on Out-of-Hospital Complications, Rehospitalization Rate, and Quality of Life of Discharged Patients with Acute Coronary Syndrome after PCI
Authors: Zhang Luyan , Tian Yaling , Ren Hong , Zhu Aihong , Dong Li , Wang Xiuqin , Han Xiaoyu
Published: July 2022

Objective. To explore the effect of percutaneous coronary intervention (PCI) standardized telephone follow-up service mode on out-of-hospital complications, rehospitalization rate, and life quality of discharged acute coronary syndrome (ACS) patients after PCI. Methods. From August 2020 to March 2022, 218 ACS patients who were discharged after PCI were included. The controls accepted routine nursing care, and the researches accepted PCI standardized telephone follow-up service mode. The nursing satisfaction, rehospitalization rate, out-of-hospital complication rate, blood lipid level, and life quality score were taken as the comparisons. Results. The nursing satisfaction of study group (100.00%) was significantly higher than that of control group (88.07%). The rehospitalization rate was dramatically lower in the study group (3/109; 2.75%) than in the control group (25/109; 22.94%) (

P
<
0.05

). In addition, compared with the control group, the incidence of complications (acute myocardial infarction and angina pectoris) was significantly reduced in the study group outside the hospital (

P
<
0.05

). The blood lipid levels of TCHO, TG, LDL-C, and HDL-C were lower in the study group than in the controls. Further, after nursing, the quality of life score of the two groups was both decreased with a higher quality of life score in the study group (

P
<
0.05

). Conclusion. The application of PCI standardized telephone follow-up service mode in discharged patients with acute coronary syndrome after PCI can reduce out-of-hospital complications and rehospitalization rate and improve blood lipid level and life quality.
An Efficient Parallel Laplace Transform Spectral Element Method for the Two-Dimensional Schrödinger Equation
Authors: Shao Wenting
Published: July 2022

In this paper, a parallel Laplace transform spectral element method for the linear Schrödinger equation and the cubic nonlinear Schrödinger equation is introduced. The main advantage of this new scheme is that it has the high accuracy of spectral methods and the parallel efficiency of the Laplace transform method. The key idea is twofold. First, Laplace transform is utilized to eliminate time dependency and the subsequent boundary value problems are discretized by using spectral element method. Second, a parallel Laplace transform method is developed to improve the computational efficiency. For the cubic nonlinear Schrödinger equation, the increment linearization technique is employed to deal with the nonlinear terms. Numerical experiments are addressed to demonstrate the accuracy and effectiveness of the proposed method. Compared with the Crank–Nicolson scheme, the CPU time is greatly saved by the parallel Laplace transform for both linear and nonlinear problems.
Influence of Iguratimod on Bone Metabolism in Patients with Rheumatoid Arthritis: A Meta-analysis
Authors: Deng Li , Yao Fangling , Tian Feng , Luo Xiaowen , Yu Shenyi , Wen Zhenhua
Published: July 2022

Background. Influence of iguratimod on bone mineral density (BMD) and biomarkers of bone metabolism in patients with rheumatoid arthritis (RA) remains not determined. Accordingly, a meta-analysis was performed for systematical evaluation. Methods. Relevant randomized controlled trials (RCTs) were retrieved by searching of PubMed, Embase, Cochrane’s Library, China National Knowledge Infrastructure (CNKI), and Wanfang databases. A random-effect model was used to pool the results. Results. In total, 24 RCTs including 2439 patients with RA contributed to the meta-analysis. Pooled results showed that compared to methotrexate alone, additional use of iguratimod 25 mg Bid for 12∼24 weeks significantly improved lumbar-spine BMD (mean difference [MD]: 0.12, 95% confidence interval [CI]: 0.04 to 0.20,

p
=
0.002

, I2 = 39%) in patients with RA. Moreover, treatment with iguratimod was associated with increased serum osteoprotegerin (MD: 180.36 pg/ml, 95% CI: 122.52 to 238.20,

p
<
0.001

, I2 = 48%), and decreased serum receptor activator for nuclear factor kappa-B ligand (MD: −10.65 pmol/l, 95% CI: −15.59 to −5.72,

p
<
0.001

, I2 = 53%). In addition, iguratimod was associated with increased bone formation markers such as the serum N-terminal middle molecular fragment of osteocalcin (MD: 4.23 ng/ml, 95% CI: 3.74 to 4.71,

p
<
0.001

, I2 = 35%) and total procollagen type I amino-terminal propeptide (MD: 9.10 ng/ml, 95% CI: 7.39 to 10.80,

p
<
0.001

, I2 = 86%), but decreased the bone resorption marker such as serum β-C terminal cross-linking telopeptide of type 1 collagen (MD: −0.18 pg/ml, 95% CI: −0.21 to −0.14,

p
<
0.001

, I2 = 70%). Conclusions. Iguratimod could prevent the bone loss and improve the bone metabolism in patients with RA.
Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing
Authors: Yang Juan , Pi Anjuan , Yan Lele , Li Juan , Nan Sha , Zhang Jing , Hao Yuhui
Published: July 2022

Propolis is a kind of reduct collected by bees from various plant sources. Because propolis is a mixture, it has a variety of biological activities, excellent anti-inflammatory and bactericidal effects. Especially in the treatment of infectious wounds, acute wounds, burns, and scalds and promoting wound healing, more and more scientists began to apply it to the research field of wound healing. The standard preparation of propolis combined with other compound components has a safer and less toxic effect in the treatment of trauma. In order to more effectively use propolis products in wound treatment. This paper reviews the effect and treatment mechanism of propolis on different types of wound healing, as well as the synergistic effect of propolis and other compounds, in order to provide ideas for the further exploration of the biological activity and pharmacological function of propolis in the future, as well as its in-depth development in the field of wound healing. It will also provide a theoretical reference for the further development and utilization of propolis.
Technology and Security Analysis of Cryptocurrency Based on Blockchain
Authors: Yu Chao , Yang Wenke , Xie Feiyu , He Jianmin
Published: July 2022

Blockchain technology applied to cryptocurrencies is the dominant factor in maintaining the security of cryptocurrencies. This article reviews the technological implementation of cryptocurrency and the security and stability of cryptocurrency and analyzes the security support from blockchain technology and its platforms based on empirical case studies. Our results show that the security support from blockchain technology platforms is signiﬁcantly insufﬁcient and immature. In addition, we further Zyskind and Nathan (2015) and Choi (2019) and find that the top ten platforms play critical roles in security support and have signiﬁcant advantages in terms of funds, duration, and human resources. Moreover, these platforms provide computational resources and beneﬁts to the consensus algorithm selection for blockchain practitioners. Second, encryption ensures the security of cryptocurrencies. On the one hand, the digital signatures identify the identity of the signatory and the transaction. However, the principle of the hash algorithm (SHA256) conﬁrms ownership. Meanwhile, SHA256 is infeasible to compute in the reverse direction and is difficult to attack. Furthermore, the records in the blockchain can be queried by every participant, making the system information transparent and open reliable. Third, compared to the study of Fu and Fang 2016, we find that the blockchain structure is composed of security components and basic components of six layers that are independent and cannot be extended completely and have a certain coupling among them. Fourth, the underlying ledger structures of Bitcoin and DAG are highly correlated to their security. Specifically, we follow Sompolinsky et al. (2016) and detect that the structure of SPECTRE ensures network security and robustness from its block production, conflict resolution, and generated trusted transaction sets. Meanwhile, the voting algorithm of SPECTRE makes resolving conflicting transactions by calculating votes and ensuring the transaction information that is virtually unable to be tampered with possible. In particular, the security calculation power of SPECTRE can reach 51% and resist “double‐spend attacks” and “censorship attacks” effectively. In addition, the RDL framework of SPECTRE achieves security conﬁrmation of transferring funds. Moreover, PHANTOM identifies evil blocks by employing block connectivity analysis and ensures its security. Eventually, we also expand the studies of (Sompolinsky et al., 2016 and Sompolinsky et al., 2017) and compare the basic characteristics of the protocols of Bitcoin, SPECTRE, and PHANTOM and find that protocols play imperative roles throughout the implementation process of cryptocurrency. In addition, the underlying ledger structure and consensus mechanism make up a blockchain while the confirmation time, throughput limit, and ordering are prerequisites for smart contracts.
TRIM66 Promotes Malignant Progression of Non-Small-Cell Lung Cancer Cells via Targeting MMP9
Authors: Xu Yufen , Yang Qi , Fang Zhixian , Tan Xiaoli , Zhang Ming , Chen Wenyu
Published: July 2022

Lung cancer has a higher incidence and mortality rate than other cancers, and over 80% of lung cancer cases were classified as non-small-cell lung cancer (NSCLC). TRIM66 is one of the crucial members of TRIM, which has a deep connection with the behavior of various malignant tumors. But it remains uncertain regarding its exact function and underlying mechanism in NSCLC. In our study, qRT-PCR and Western blot were employed to validate that TRIM66 was overexpressed in NSCLC. The migration, invasion, and epithelial-mesenchymal transformation (EMT) progression of NSCLC cells were determined by Western blotting and Transwell experiments after knocking down TRIM66, and it was found that knockdown TRIM66 inhibited the migration, invasion, and EMT processes of NSCLC cells. Next, the binding relationship between TRIM66 and MMP9 was verified by Co-IP assay. After determining the interaction between them, rescue assays showed that overexpression of MMP9 was capable to promote the migration, invasion, and EMT of NSCLC cells. However, the transfection of si-TRIM66 could reverse this facilitating effectiveness. To sum up, we concluded that by targeting MMP9, TRIM66 could exert a cancer-promoting role in the progression of NSCLC cells.
Intelligent City 3D Modeling Model Based on Multisource Data Point Cloud Algorithm
Authors: Wu Youping , Zhou Zhihui
Published: July 2022

With the rapid development of smart cities, intelligent navigation, and autonomous driving, how to quickly obtain 3D spatial information of urban buildings and build a high-precision 3D fine model has become a key problem to be solved. As the two-dimensional mapping results have constrained various needs in people’s social life, coupled with the concept of digital city and advocacy, making three-dimensional, virtualization and actualization become the common pursuit of people’s goals. However, the original point cloud obtained is always incomplete due to reasons such as occlusion during acquisition and data density decreasing with distance, resulting in extracted boundaries that are often incomplete as well. In this paper, based on the study of current mainstream 3D model data organization methods, geographic grids and map service specifications, and other related technologies, an intelligent urban 3D modeling model based on multisource data point cloud algorithm is designed for the two problems of unified organization and expression of urban multisource 3D model data. A point cloud preprocessing process is also designed: point cloud noise reduction and downsampling to ensure the original point cloud geometry structure remain unchanged, while improving the point cloud quality and reducing the number of point clouds. By outputting to a common 3D format, the 3D model constructed in this paper can be applied to many fields such as urban planning and design, architectural landscape design, urban management, emergency disaster relief, environmental protection, and virtual tourism.
Mobile Terminal Equipment and Methods of Martial Arts Movement Correction in Intelligent Physical Education Environment
Authors: Xu Meng , Shi Yaya
Published: July 2022

In recent years, the physical quality of middle school students in China has generally declined, which has attracted the attention of the state and the Ministry of education. With the development of Internet technology, China’s physical education teaching environment has gradually become intelligent. This article mainly studies the mobile terminal equipment and methods of martial arts movement correction in the intelligent physical education environment. 21 young martial arts athletes were selected as the research objects. In the experiment, functional screening (FMS) was used to test the martial arts athletes, followed by FMS tests and scores. A video camera was used to record the motion test from the subjects’ sagittal and frontal planes. Using wireless sensor technology to collect the athletes’ motion signals, after the twelfth week, the FMS, SEBT, and the number of successful routines were tested on the two groups of athletes, respectively. The pre-test data and the post-correction data of the two test indicators were compared and analyzed. There is no significant difference. The necessary statistics and integration of the obtained data are carried out by using the calculation methods in sports statistics. The experimental data showed that the average total scores of FMS screening test of Changquan athletes and Taijiquan athletes were 14.71 ± 1.52 and 16.20 ± 1.32, respectively. The results of the research on the mobile terminal equipment and methods of martial arts movement correction in the intelligent sports environment show that the mobile terminal equipment can improve the independent training ability of athletes, and at the same time has a good correction effect on irregular movements.
Dynamical Alert of Thought and Politics Teaching Based on the Long- and Short-Term Memory Neural Network
Authors: Hu Xiaodi , Sturdivant David
Published: July 2022

To strengthen and develop the thought and politics work in state-owned schools, schools must explore the theoretical system of thought and politics construction in the practice of scientific development ideas guiding school development, actively innovate the practice model and implement early warning management for thought and politics projects. This is because only by accurately analyzing the problems and causes can we seek more reasonable measures for the laws of thought and politics practice education for modern students. At present, promoting the deep integration of thought and politics teaching projects with information technology has become an important means of thought and politics teaching projects in schools. However, with the explosive growth of network data, the structure becomes more and more complex, and learners face the problem of information overload as more and more information overflows in the network environment. Precise support for students with learning disabilities is a research direction for precision thinking education, and most existing support strategies in schools include manual statistics of failed subjects, written warnings, or corrective measures through simple correlation algorithms. In this paper, we propose a dynamical alert for thought and politics teaching based on the Long-Short-Term Memory Neural Network (LSTM), which uses a powerful global optimization function to optimize the parameters of the deep LSTM neural network. The experimental results show that the average execution time of LSTM is 19.46 seconds and 8.24 seconds lower than that of SCB-DBSCAN and CFSFDP, respectively, which shows that the execution time of the LSTM algorithm is faster and more accurate. Therefore, the LSTM algorithm is feasible and effective. The LSTM-based dynamic warning of thought and politics teaching can predict students’ subject performance more accurately and has certain validity and feasibility.
A Cross-Sectional Seroepidemiological Study on Infectious Bursal Disease in Backyard Chickens in the Mymensingh District of Bangladesh
Authors: Mili Sharmin Akhter , Islam Md. Saiful , Al Momen Sabuj Abdullah , Haque Zobayda Farzana , Pondit Amrita , Hossain Md. Golzar , Hassan Jayedul , Saha Sukumar
Published: July 2022

Infectious bursal disease (IBD) is a highly contagious disease that causes significant economic loss in chickens. A cross-sectional study was conducted in the Mymensingh district of Bangladesh to determine the seroprevalence of IBD virus (IBDV) antibodies in backyard chickens and their association with different epidemiological risk factors. A total of 460 serum samples were randomly collected from backyard chickens that had not been previously vaccinated against IBDV. The collected sera were examined using an enzyme-linked immunosorbent assay (ELISA). Data on epidemiological risk factors were collected through face-to-face interviews with owners and subjected to both uni- and multivariable risk analyses to determine their association with IBDV infection. Using ELISA, the overall seroprevalence of IBDV antibodies in backyard chickens was 83.4% (95% confidence interval: 79.8%–86.6%), among which, a significantly higher seroprevalence was recorded in females (83.4%, 345/350), 4–6 weeks age group (95.3%, 244/256), and unhealthy (95.0%, 57/60) backyard chickens than those of males, other age groups, and healthy chickens, respectively. Furthermore, chickens reared in free-ranging housing systems (93.3%, 280/300) and poor-conditioned houses (98.0%, 147/150) showed a significantly higher seropositivity of IBDV antibodies than those reared in separated housing systems and other hygienic-conditioned houses, respectively. Moreover, compared with their counterparts, a higher but nonsignificant seroprevalence of IBDV antibodies was observed in backyard chickens that were selected from Fulbaria Upazila (88.8%; 80/90) and which were brought from the marketplace (85.7%, 60/70). A higher seropositivity of IBDV antibodies was shown to be statistically associated with various critical epidemiological risk factors, indicating that field strains of IBDV were exposed in backyard chickens and could be readily transferred horizontally. Proper prevention and control methods, villagers’ awareness of IBD, and the rapid and widespread use of seroepidemiological investigations could help to reduce the spread of IBDV infection in backyard chickens.
miR-135a-5p Suppresses TBK1 and Activates NRF2/TXNIP Antioxidant Pathway in LPS-Driven ALI in Mice
Authors: Zou Guotao , Zeng Yiwen , Wang Yingjuan , Luo Yong
Published: July 2022

Objective. Acute inflammation and oxidative stress are present in large numbers in patients with acute lung injury (ALI). This investigation probed miR-135a-5p/TBK1 axis within ALI together with its new therapeutic target. Methods. MLE-12 cultures were treated with lipopolysaccharide (LPS) and transfected with miR-135a-5p mimics or TBK1 vector. An ALI mouse model was also established. Analysis was done on the relationships between TBK1 and miR-135a-5p. Inflammatory components, SOD, MDA, and ROS content were all assessed. Results. Obvious inflammatory lesions were observed in lung tissues of ALI mice. Overexpression of miR-135a-5p or TBK1 knockdown remarkably decreased IL-1β, IL-6, and TNF-α serum concentrations and increased IL-10 level within lung tissues. Activated NRF2/TXNIP pathway and oxidative stress were additionally found within ALI murines, which were regulated by miR-315a-5p and TBK1. Further research revealed that miR-135a-5p negatively regulated TBK1 expression to mediate proinflammatory response and oxidative stress. Conclusion. miR-135a-5p targeted TBK1 to regulate inflammatory/oxidative stress responses in ALI. Such results might bring a new potential target for ALI treatment.
Alcohol Extract of YFXJ Decoction Reverses the Drug Resistance of Human Lung Adenocarcinoma Cell Line A549/DDP
Authors: Liu Zhongliang , Ding Yaping , Tian Yizhou , Yu Da
Published: July 2022

Objective. Lung cancer is the wide and common tumor. This study was designed to explore the effect of YFXJ formula on non-small-cell lung cancer (NSCLC) cell lines. Methods. YFXJ formula (mainly composed of Astragalus membranaceus, Atractylodes macrocephala, Radix Saposhnikoviae, Radix Glehniae, coix seed, Herba Sabina chinensis, Hedyotis diffusa, Pericarpium Citri Reticulatae, sarcophagus martensii, Prunella vulgaris, Meretrix meretrix, and oyster) was extracted with 75% ethanol. We performed MTT, FACS, TUNEL, and mass spectrometry to study the effect of YFXJ formula on A549/DDP cells. Results. The results showed that YFXJ could inhibit the growth of A549/DDP cells, and it can reverse the sensitivity of A549/DDP cells to cisplatin. YFXJ inhibits the expression of MDR1, MRP1, and LRP genes in A549/DDP cells. Conclusion. YFXJ formula can reverse the drug resistance of A549/DDP cell, which could be through activation of autophagy.
[Retracted] Synergistic Effect Analysis of Ecological Protection and Environmental Law and Ecological Civil Code
Authors: Zeng Linyichen , Zhang Shuo
Published: July 2022

In order to further curb the damage to the ecological environment from the perspective of legal synergistic supervision, a synergistic analysis method between the ecological protection environmental law and the ecological Civil Code is proposed. Coordinated supervision, with the new Civil Code as the research background, from the perspective of interpretation, explores the solution to the problem of “ecological environmental damage” in the newly promulgated Civil Code for behavior that damages the ecological environment. The research results believe that, from the perspective of rights, environmental rights should be regarded as the concentrated expression of rights in the sense of private law in the ecological environment law. Article 1234 of the Tort Liability Section stipulates that “the state‐specified agency or the law‐specified organization” as the representative of environmental public interests proposes damage. The request resolves the legitimacy of relevant agencies and organizations as civil subjects to represent environmental public interests. Finally, it clearly stipulates the responsibility for ecological restoration, expands the way of undertaking tort liability caused by environmental damage, and solves the problem that it was limited to “restoration” in the past and could not be actually performed.
Application of Artificial Intelligence Technology in Computer Network Security Communication
Authors: Li Fulin
Published: July 2022

In order to cope with the frequent challenges of network security issues, a method of applying artificial intelligence technology to computer network security communication is proposed. First, within the framework of computer network communication, an intelligent protocol reverse analysis method is proposed. By converting the protocol into an image and establishing a convolutional neural network model, artificial intelligence technology is used to map the data to the protocol result. Finally, use the model to test the test data to adjust the model parameters and optimize the model as much as possible. The experimental results show that compared with the test model, the results obtained after training with the deep convolutional neural network model in this paper have increased the accuracy by 2.4%, reduced the loss by 38.2%, and reduced the running time by 42 times. The correctness and superiority of the algorithm and model are verified.
Pediatric Cancer By Race, Ethnicity and Region in the United States
Authors: Rees Judy R. , Weiss Julie E. , Riddle Bruce L. , Craver Karen , Zens Michael Scot , Celaya Maria O. , Peacock Janet L.
Published: July 2022

Background:

In a 2018 descriptive study, cancer incidence in children (age 0–19) in diagnosis years 2003 to 2014 was reported as being highest in New Hampshire and in the Northeast region.

Methods:

Using the Cancer in North America (CiNA) analytic file, we tested the hypotheses that incidence rates in the Northeast were higher than those in other regions of the United States either overall or by race/ethnicity group, and that rates in New Hampshire were higher than the Northeast region as a whole.

Results:

In 2003 to 2014, pediatric cancer incidence was significantly higher in the Northeast than other regions of the United States overall and among non-Hispanic Whites and Blacks, but not among Hispanics and other racial minorities. However, there was no significant variability in incidence in the states within the Northeast overall or by race/ethnicity subgroup. Overall, statistically significantly higher incidence was seen in the Northeast for lymphomas [RR, 1.15; 99% confidence interval (CI), 1.10–1.19], central nervous system neoplasms (RR, 1.12; 99% CI, 1.07–1.16), and neuroblastoma (RR, 1.13; 99% CI, 1.05–1.21).

Conclusions:

Pediatric cancer incidence is statistically significantly higher in the Northeast than in the rest of the United States, but within the Northeast, states have comparable incidence. Differences in cancer subtypes by ethnicity merit further investigation.

Impact:

Our analyses clarify and extend previous reports by statistically confirming the hypothesis that the Northeast has the highest pediatric cancer rates in the country, by providing similar comparisons stratified by race/ethnicity, and by assessing variability within the Northeast.
Cancer Effects of Low to Moderate Doses of Ionizing Radiation in Young People with Cancer-Predisposing Conditions: A Systematic Review
Authors: Canet Maelle , Harbron Richard , Thierry-Chef Isabelle , Cardis Elisabeth
Published: July 2022

Moderate to high doses of ionizing radiation (IR) are known to increase the risk of cancer, particularly following childhood exposure. Concerns remain regarding risks from lower doses and the role of cancer-predisposing factors (CPF; genetic disorders, immunodeficiency, mutations/variants in DNA damage detection or repair genes) on radiation-induced cancer (RIC) risk. We conducted a systematic review of evidence that CPFs modify RIC risk in young people. Searches were performed in PubMed, Scopus, Web of Science, and EMBASE for epidemiologic studies of cancer risk in humans (<25 years) with a CPF, exposed to low–moderate IR. Risk of bias was considered. Fifteen articles focusing on leukemia, lymphoma, breast, brain, and thyroid cancers were included. We found inadequate evidence that CPFs modify the risk of radiation-induced leukemia, lymphoma, brain/central nervous system, and thyroid cancers and limited evidence that BRCA mutations modify radiation-induced breast cancer risk. Heterogeneity was observed across studies regarding exposure measures, and the numbers of subjects with CPFs other than BRCA mutations were very small. Further studies with more appropriate study designs are needed to elucidate the impact of CPFs on RIC. They should focus either on populations of carriers of specific gene mutations or on common susceptible variants using polygenic risk scores.
Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients Aged 85 Years Old or Older Is Associated with a Good Prognosis Compared to Conservative Treatment without Any Invasive Procedure
Authors: Yamada Shinya , Dohi Osamu , Harusato Akihito , Iwai Naoto , Horie Ryusuke , Yasuda Takeshi , Yamada Nobuhisa , Horii Yusuke , Majima Atsushi , Zen Keika , Kimura Hiroyuki , Yagi Nobuaki , Naito Yuji , Itoh Yoshito
Published: July 2022

Introduction: Studies have reported the feasibility of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in elderly people with respect to both short- and long-term outcomes. As the elderly population in society increases, the requirement for managing super-elderly patients aged ≥85 years with EGC will also increase. This study aims to identify the long-term clinical outcomes of ESD for clinical T1N0 EGC in patients aged ≥85 years. Methods: A total of 370 consecutive patients aged ≥85 years with clinical T1N0 EGC who were managed in 11 institutions were reviewed retrospectively. On the basis of treatment strategy, we compared the overall survival (OS) and disease-specific survival (DSS) after performing propensity score-matched analysis between patients undergoing ESD (ESD group) and those not undergoing treatment (conservative treatment group). The potential prognostic factors were also investigated in the propensity score-matched patients. Results: After propensity score matching, we found that the 3-year OS and DSS rates were significantly higher in the ESD group than in the conservative treatment group (OS, 82.2% vs. 50.5%; p < 0.001; DSS, 100% vs. 80.1%; p = 0.008). Furthermore, ESD was identified as a significant factor for prolonged OS, whereas Charlson comorbidity index (CCI) ≥3 and prognostic nutritional index (PNI) <36.2 were associated with reduced OS. Conclusion: ESD was associated with improved OS in patients with clinical T1N0 EGC aged ≥85 years compared with the absence of treatment. Furthermore, CCI and PNI were helpful for patient selection.
Katheterbasierte Luftstrommessung zur Beurteilung der Kollateralventilation: Kein Unterschied zwischen Spontanatmung und HF-Jetventilation
Authors: Kempa Axel Tobias
Published: July 2022

Background: Endobronchial valve therapy has proven to reduce lung hyperinflation and decrease disease burden in patients with severe lung emphysema. Exclusion of collateral ventilation (CV) of the targeted lobe by using an endobronchial assessment system (Chartis; PulmonX, Drive Redwood City, CA, USA) in combination with software-based fissure integrity analysis (FCS [fissure completeness score]) of computed tomography scans of the lung are established tools to select appropriate patients for endobronchial valve treatment. So far, there is no conclusive evidence if the ventilation mode during bronchoscopy impacts the outcome of Chartis assessments. Methods: Patients with Chartis assessments and software-based quantification of FCS (StratX; PulmonX, Drive Redwood City, CA, USA) were enrolled in this retrospective study. During bronchoscopy, pulmonary fissure integrity was evaluated with the Chartis assessment system in each patient first under spontaneous breathing and subsequently under high-frequency (HF) jet ventilation. Results: In total, 102 patients were analyzed. Four Chartis phenotypes CV positive (CV+), CV negative (CV-), low flow, and low plateau in spontaneous breathing and HF jet ventilation were identified. The frequency of each Chartis phenotype per lobe was similar in both settings. When comparing Chartis assessments in spontaneous breathing and HF jet ventilation, there was an overall good concordance rate for all analyzed fissures. In agreement, receiver operating characteristic analysis of the FCS showed an almost similar prediction for CV+ and CV- status independent of the ventilation modes. Conclusion: Chartis assessment in spontaneous breathing and HF jet ventilation had similar rates in detecting CV in lung emphysema. Our results suggest that both modes are equivalent for the assessment of CV.