bluuebunny/crossref_metadata_2025 huggingface dataset:
The Possible Impact of Quantum Annealing on Cybersecurity
Authors: Leśniak Mateusz , Wroński Michał , Burek Elżbieta
Published: December 2024

Quantum annealing is an approach to quantum computing that serves as an alternative to general-purpose quantum computing. However, the cryptographic community does not currently view quantum annealing as a significant threat to cryptographic algorithms. Recent findings indicate that quantum annealing could be used for the efficient cryptanalysis of stream ciphers. Furthermore, although additional analysis is necessary, cryptanalysis with quantum annealing appears to require a relatively small amount of resources, suggesting its practical applicability. This contrasts with Grover's algorithm, which necessitates quantum circuits of substantial depth and billions of quantum gates. This paper will explore the potential cybersecurity risks if the implications of quantum annealing are not taken seriously.
The Safety Management System in Aviation Companies
Authors: Kałużna Ewa
Published: December 2024

This article presents the key elements of the functioning of the safety management system in an aviation organization. Enterprises must have safety-related issues in line with international and internal regulations. While striving to achieve an acceptable level of safety, enterprises develop safety indicators, the purpose of which is, among other things, to assess the effectiveness of the safety management system. In order to respond appropriately to an emerging threat, it is necessary to have a mechanism for efficiently assessing risks and their severity, thanks to which the units responsible will be able to develop a plan for necessary actions to weaken or completely eliminate the threat.
The Ukrainian War of Values
Authors: Rosół Piotr
Published: December 2024

The role of ethical values in history is often overlooked. The main role ascribed to the political, economic and military aspects of history diminishes the role of norms and values. At the same time, the perspective concentrating on the history of culture, mentality and daily life provides a viewpoint from which ethical norms and values are treated as an aspect of culture and have limited influence on other aspects of history.
In this paper, I present the importance of ethical values and historical justifications, referring to them based on the example of Volodymyr Zelenskyy’s speeches during the first year of Russia’s full-scale war against Ukraine. This provides an opportunity to analyze an example of the role ethical values play in the Ukrainian struggle against Russia and justify the thesis that ethics plays an important part in geopolitical security and defense.    
This paper consists of four parts: first, the author briefly describes the importance of ethical values for historiography and certain aspects of the historical context in which Zelenskyy’s speeches will be interpreted throughout the text. Secondly, the issue of nihilism in history is described, with particular attention to Zelenskyy’s opposition toward it. The next part describes historical determinism as a tool to justify abhorrent actions, and the final part describes the value ascribed to freedom by Zelenskyy, especially as a prerequisite for the existence of other ethical values and as a method to search for an answer to aggression, war, and evil.
Adapting to New Threats on the Example of Byzantine Eastern Frontier in the Tenth Century CE
Authors: Wierzbiński Szymon
Published: December 2024

One of the most important challenges every country faces is the ability to respond to the changing political environment. History provides enormous material in this regard, which is eagerly used by scholars, for example, in the discourse on conflicts and wars. In this respect, the course of the Byzantine-Arab conflict in the tenth century is particularly worth mentioning. In this text, the author attempts to identify the mechanisms of reforms in the administrative and military spheres that allowed the Empire to avert a crisis on its eastern borders and, over time, go on the offensive. Due to the specificity of the field of knowledge, the dominant research method was source confrontation and discussion with the literature on the subject. This text is divided into several parts, including the introduction, the part devoted to administrative reforms, the part relating to reforms in the functioning of the army (general remarks, discipline, battle preparation, aftermath instructions, preferences regarding the selection of commanders) and the summary. It appears that the reforms implemented by the Byzantine Empire were deliberate and resulted in averting the Arab threat in the tenth century.
A Study of the Trajectory of an Aerobalistic Rocket Based on the 9m723 Missile
Authors: Dziczkaniec Rafał , Noga Tomasz , Matysek Krzysztof , Umiński Piotr
Published: December 2024

This article presents the modeling of and research on the flight trajectory of an aeroballistic missile using MATLAB/Simulink software. This article adopts the 9M723 rocket as a focus of research because the Iskander system missile is an ideal example of an SRBM (Short-range ballistic missile), which, due to the shape of its flight trajectory, is quite a challenge for the defending side. The research was carried out by performing a series of computer simulations of the 9M723 rocket model in six degrees of freedom, where flight parameters were examined for the boost, mid-course and terminal phases. The parameters of the 9M723 rocket were gathered from publicly accessible data, with estimations of mass-inertial, aerodynamic, and motor thrust characteristics conducted using AutoCAD and Prodas software tools. Simulation studies show an envelope of possible trajectories of the 9M723 missile. Terminal maneuvers result in a significant reduction in the final velocity of the missile. Moreover, the maneuvering capabilities of the Iskander system rocket above 25 km altitude are very limited due to the small control surface and low air density. Due to its high velocity during flight (up to 2 km/s), the Iskander remains in the theoretical missile defense range only temporarily. The research conducted on the trajectory of an aeroballistic missile allows us to learn the flight parameters of SRBMs and investigate the spectra of threats that anti-missile defense systems face.
The flight simulation program used in this article was initially developed to analyze civil rockets. However, for the purpose of this article, it has been adapted for the analysis of a military rocket.
Targeting Potential of Iron Oxide Nanoparticles and Gallic Acid Decorated Nano Lipidic Carriers-Infused Lipid Nanoparticles- In-vitro and In-vivo Studies
Authors: V Sandhiya
Published: December 2024

I was investigating the essay with the aforementioned title, which appears to be both innovative and crucial. Gallic acid exhibits lipid oxidation activity and possesses antioxidant properties. The environmental sensitivity presents the potential for the advancement of new carrier systems. The detrimental side effects of traditional cancer therapies aggravate the condition, and therapeutic options are limited.
Formulation of Morinda Citrifolia L. Dried Extract in Tablet form by Direct Compression and Evaluation Using Design of Experiments
Authors: S.T.V. Raghavamma , Bodi Sai Krishnaveni , Nadendla Rama Rao
Published: December 2024

Introduction: The work aims to prepare tablets of Morinda citrifolia hygroscopic dry powder extract by direct compression method and applying DoE 32 factorial design. 
Methods: All the statistical calculations and interpretation of the results were carried out using the Design Experiment 10 software version. Nine different formulation trials were conducted. Varying concentrations of binder (Ethyl cellulose) and disintegrating agents (Microcrystalline cellulose) are considered as two independent variables. Magnesium stearate, polyethene glycol-4000, sucrose and starch are used as bulking agents. The effect of the two variables on the hardness, time of disintegration and in vitro drug release were evaluated. 
Results: All the materials were compatible and found stable during the study.  Among the nine different formulations, F9 formulation with binder and disintegrating in a 20:40 ratio showed 90.31% drug release. From the overlay plot, the F10 checkpoint batch was formulated and evaluated. F10 formulation was the most suitable formulation with a hardness of 5.2Kg/cm2, a disintegrating time of 31.6 min with 86.98% drug release.
Conclusion: DoE 32 factorial design can be used to formulate tablets of Morinda citrifolia hygroscopic dry powder extract. The F10 formulation is considered as the optimized preparation. According to the Design of experiments, it is concluded that as the concentration of binder and disintegrating agent increases then the hardness, disintegration and percent drug release of the formulation also increases.
Solid Dispersion Incorporated Indomethacin Oro- Dispersible Tablet
Authors: Qureshi Aminabi , Shaikh Umaima , Shaikh Mehrunnisa , Parkar Wafa , Lal Maria , Baig Mirza Salman
Published: December 2024

Aim: This study aimed to enhance the dissolution profile of indomethacin by formulating oro-dispersible tablets, using the Solid Dispersion technique and PEG 6000 and PVP K-30 as carriers.
Method: Solid Dispersion (SD) of indomethacin were prepared using the kneading method. Pre-compression studies include evaluating granules' density and flow properties, while post-compression studies assessed tablet properties such as hardness, friability, wetting time, dissolution, drug content and material interactions.
Result: All pre- and post-compressional parameters were found within pre-determined limits. FTIR indicated no remarkable interaction between the polymers and the drug in the SDs. The dissolution study showed that the formulation with a 1:1 ratio of indomethacin to PVP K-30 and PEG 6000 exhibited the fastest dissolution rate, releasing 99.53% of the drug within 15 minutes.
Conclusion: The study successfully formulated oro-dispersible tablets of indomethacin using the SD technique with PVP K-30 and PEG 6000 as carriers. These SD granules exhibited excellent flow properties. Whereas tablets showed appropriate physical characteristics, and rapid dissolution rates, which can improve effectiveness of the drugs like indomethacin. This approach offers a promising solution for patients who have trouble taking tablets.
Cutting-Edge Developments in utilizing Lipid Nano-carrier for Enhanced Drug Delivery
Authors: Chauhan Dr. Shikha Baghel , Singh Astha , Singh Indu
Published: December 2024

Nanocarriers have emerged as promising drug delivery systems due to their unique properties and capabilities. This abstract provides an overview of the concept of nanocarriers as drug delivery systems, highlighting their significance and potential applications. The report begins by introducing the background and significance of drug delivery systems. It emphasizes the limitations of conventional drug delivery methods and the need for more efficient and targeted approaches. Nanocarriers offer a solution to these challenges by providing controlled and targeted drug delivery, leading to improved therapeutic outcomes. The advantages and challenges of nanocarriers as drug delivery systems are discussed. The advantages include enhanced drug stability, prolonged drug release, improved bioavailability, and targeted delivery to specific tissues or cells. However, challenges such as manufacturing complexity, regulatory considerations, and potential toxicity need to be addressed for successful clinical translation. The report then highlights the different types of nanocarriers used in drug delivery, including lipid-based nanocarriers, polymeric nanocarriers, and inorganic nanocarriers. Each type is briefly described, along with their synthesis methods, properties, and applications. The report also covers the principles of drug delivery using nanocarriers, focusing on the mechanisms of drug loading and release from nanocarriers. It discusses the factors influencing drug release kinetics and the strategies employed for enhanced drug delivery, such as targeting strategies. Finally, the report concludes by emphasizing the importance of nanocarriers in various therapeutic applications, including cancer drug delivery, central nervous system drug delivery, gene delivery, vaccines, and treatment of infectious diseases. It also highlights the future perspectives and challenges in the field of nanocarrier-based drug delivery systems.
Digital Twins in Drug Discovery: A Paradigm Shift Shaping Pharmaceutical Innovation
Authors: VT Iswariya , Asireddy Sathvika Reddy , Vallarapu Nanda Krishnaveni , Madhira Jayaprakash , T Ramarao
Published: December 2024

Digital twin technology is a groundbreaking concept of constructing virtual replicas of physical entities and processes. It operates at the juncture of Artificial Intelligence and the Internet of Things, emerging as a significant competence in Model-Based Systems Engineering (MBSE). This transformative technology fosters a profound link between the digital and physical realms by incorporating physical models, sensor updates, multidisciplinary models, and multi-scale and multi-probability simulations in a virtual space. The applications of digital twins extend across diverse domains, including industrial production, product design, healthcare, and drug discovery. Benefits encompass predictive modelling, cost reduction, personalized medicine, and improved quality control. Nevertheless, digital twin technology challenges complexity, validation, quality assurance, and availability. In the pharmaceutical sector, digital twins are poised to revolutionize drug development, accelerate clinical trials, and enhance the safety and efficacy of pharmaceuticals. In networking, they also promise efficient data-driven network management, enabling innovation and rich network applications. However, this evolution has challenges, particularly the stringent regulatory requirements, data privacy concerns, and ethical implications. As digital twin technology matures, it will be pivotal in reshaping the future of healthcare and pharmaceuticals. This dynamic transformation signifies the industry's commitment to innovation, with the promise of delivering enhanced patient outcomes while remaining steadfast in compliance with evolving regulatory standards.
PTK Kolaboratif: Pembelajaran Kooperatif TGT Berbatuan Permainan CTA dalam Meningkatkan Keaktifan Peserta Didik pada Pembelajaran Kimia
Authors: Ifan Rivaldo  , Andromeda Andromeda  , Laksminawati Yunaz  , Nofri Yuhelman
Published: December 2024

Penerapan pembelajaran berkelompok berbantuan LKPD dengan model pembelajaran tertentu belum mampu memaksimalkan keterlibatan dan keaktifan peserta didik selama belajar karena cenderung hanya mengandalkan teman kelompoknya. Penelitian ini dilakukan sebagai upaya memperbaiki kualitas pembelajaran kimia dari segi keaktifan peserta didik melalui penggunaan pembelajaran kooperatif tipe Teams Game Tournament (TGT) berbantuan permainan Choose Take Answer (CTA). Penelitian dilakukan terhadap 33 peserta didik kelas X SMA pada bulan Mei selama dua siklus. Setiap siklus meliputi beberapa tahapan yaitu perencanaan, pelaksanaan, observasi, dan refleksi. Setiap rangkaian kegiatan penelitian dilakukan secara kolaboratif bersama dosen pembimbing, guru kimia, dan rekan sejawat. Lembar observasi digunakan untuk mencatat aktivitas belajar peserta didik yang meliputi aktivitas belajar dasar (mengamati, menanya/mencoba, dan mencari) dan aktivitas belajar lanjut (berdialog, mengkomunikasikan, dan berkolaborasi) sebagai indikator keaktifan peserta didik selama tindakan. Data yang diperoleh dianalisis secara deskriptif kuantitatif. Hasil penelitian menunjukkan keaktifan peserta didik pada pembelajaran kimia pada siklus I sebesar 50,5% (kategori sedang) dan siklus II sebesar 72,1% (kategori sedang). Peningkatan keaktifan terjadi secara signifikan mulai dari sebelum tindakan, tindakan siklus I, hingga tindakan siklus II dengan besar kenaikan dari keadaan awal sebesar 31,8%. Hasil ini menunjukkan keaktifan belajar peserta didik pada pembelajaran kimia dapat ditingkatkan melalui penerapan pembelajaran kooperatif TGT berbantuan permainan CTA, sehingga dapat diterapkan pada pembelajaran di sekolah sebagai alternatif solusi untuk meningkatkan aktivitas peserta didik.
IMPLEMENTATION OF MONITORING SIDE EFFECTS OF DRUGS IN DRUG-RESISTANT TUBERCULOSIS PATIENTS IN REFERRAL HOSPITALS: A QUALITATIVE STUDY
Authors: Elmiawati Latifah  , Endang Yuniarti  , Rinto Susilo  , Hidayah Karuniawati  , Azizah Nur , Dyah Aryani Perwitasari  , Syifa Imelda
Published: December 2024

Drug-resistant tuberculosis (TB) is a public health problem that poses major challenges to patients, health workers, society, and the health care system. This research is a qualitative study to explore the implementation of drug side-effect monitoring and the role of health workers in handling side-effect monitoring medication for tuberculosis patients. We collected data through Focus Group Discussions (FGD) and conducted direct, in-depth interviews. The informants in this study were doctors, pharmacists, and nurses who were directly involved in treating drug-resistant tuberculosis patients. Two drug-resistant TB referral hospitals in the Cirebon area hosted the research. INVIVO 12 was used for qualitative analysis. Both hospitals still need to optimise the mechanism for tracking drug side effects in drug-resistant TB patients in accordance with the technical guidelines. Doctors at both hospitals play a significant role in implementation compared to other health workers. The similar role of doctors in both hospitals in implementation is in initial examination and history taking, determining causality, management, and education regarding drug side effects. Pharmacists have a similar role in managing drug side effects and documenting "unwanted events". The role of nurses in both hospitals is similar, namely providing patients with education on drug side effects. Efforts are needed to increase the implementation of monitoring of drug side effects by conducting assessments of the causality of drug side effects and documentation using specific instruments according to standards, ensuring the ensuring the completeness of manual monitoring forms, and providing continuous drug side effect monitoring training for health workers.
Síndrome Torácico Agudo en pacientes con Anemia Falciforme: Reporte de dos casos en pediatría
Authors: Chu Eleisca , Jaramillo Jonathan , Wald Yara , Luis Aida , Caparó Elizabeth , González Benilda
Published: December 2024

Introducción: El Síndrome Torácico en drepanocitosis, se define como un proceso agudo caracterizado principalmente por fiebre y dolor torácico, acompañado de nuevos infiltrados en la radiografía de tórax. Caso Clínico: Los pacientes pueden debutar con un síndrome torácico como se describe en el segundo caso o desarrollarlo durante una estancia hospitalaria causada por otro proceso, como se describe en el primer caso. Es la segunda complicación más frecuente y puede afectar a cualquier grupo de edad, con pico de incidencia entre los 2 y 4 años. Es un cuadro que puede ser muy severo con riesgo vital, por lo que su sospecha, reconocimiento y vigilancia evolutiva, determina en muchos de ellos el pronóstico. Se presentan 2 casos de pacientes con Síndrome Torácico que presentaron pródromos distintos, en donde el enfoque multidisciplinario jugó un papel crucial en la evolución satisfactoria de ambos.
Desafío diagnóstico
Authors: Cueto-Felgueroso Ferrero Paula
Published: December 2024

Paciente masculino de 12 años, sin antecedentes personales de interés, procedente del área del Darién. Consulta en Hospital debido a fiebre no cuantificada periódica, astenia, anorexia y pérdida de peso de un mes de evolución. Asociando la última semana cuadro de dificultad respiratoria progresiva. En la radiografía de tórax se observa cardiomegalia (Figura 1) por lo que se realiza ecocardiografía donde se observa dilatación severa de las 4 cavidades cardíacas. Al reinterrogar a la familia del paciente refieren que previamente vivían en la zona de Bocas del Toro, en una casa de madera, donde había chinches y alacranes.
Resolution of Credit Agreement Disputes Due To Force Majeure From The Perspective of Syariah Banking
Authors: Addinur Addinur , Djaja Benny , Sudirman Maman
Published: December 2024

This study analyzes the impact of recession on credit contracts in Islamic banking, especially in e-commerce activities. Murabahah-based credit contracts, which are used as financing products based on credit sales, involve the customer's obligation to pay installments according to the agreement. However, recessionary conditions create difficulties for customers in fulfilling their obligations, thus creating the potential for payment delays that can be detrimental to the bank. From an Islamic legal perspective, conditions beyond human control, such as recession, can be categorized as force majeure, which provides a legal basis for customers to delay payments. Legal resolution of this situation requires an approach that accommodates the principle of justice, where the imposition of fines for delayed payments is often viewed as a form of usury by some scholars, because it is considered an addition that is not in accordance with Islamic principles. This study aims to provide a comprehensive understanding of dispute resolution based on the concept of murabahah in Islamic banking, by considering the impact of recession on the sustainability of credit contracts, while offering solutions that are in line with Islamic legal principles and protection of the rights of customers and banks.
Prediction of Poisson's ratio for hydraulic fracturing operations in the Oligocene formations in the Bach Ho field
Authors: Truong Tu Van , Nguyen Vinh The , Nguyen Long Khac , Nguyen Thinh Van , Nguyen Hung Tien , Nguyen Tai Trong , Kieu Thinh Duc ,   Hanoi University of Mining and Geology, Hanoi, Vietnam
  Zarubezhneft E&P Vietnam, HoChiMinh City, Vietnam
  Thuy Loi University, Hanoi, Vietnam
Published: December 2024

In rock geomechanics analysis, Poisson's ratio is one of the critical factors that affect mechanical properties of rocks and soils, wellbore stability, in situ stress, drilling efficiency, and hydraulic fracturing design. There are two conventional methods for measuring Poisson's ratio, they are called acoustic wave method and compression testing of core sample. In the first, the Poisson's ratio is determined based on well-log data known as dynamic values. Conversion formulas need to be established for different geological conditions to obtain reliable computational results. However, the determination of each suitable conversion formula is time and money-consuming, as well as the process, is relatively complicated. The latter method must be performed in the laboratory with high accuracy equipment and requires the availability of core samples obtained through the coring process with high expenditure. To overcome the limitations of these two methods, the authors used the Artificial Intelligence technique to establish correlations between the value of Poisson's ratio and drilling parameters (e.g., weight on bit, flow rate, torque, annulus velocity, pressure losses) in the Oligocene formation of the Bach Ho field. Two machine learning algorithms including Random Forest (RF) and Decision Tree (DT) were applied in this study. On the other hand, the offset data from Well A and Well B penetrated through the Oligocene formation of the Bach Ho field were used to build, train, and verify the accuracy of the artificial intelligence simulations. Both wells have similarities in lithological characteristics and composition. The results indicated that the Artificial Intelligence models are highly accurate in predicting the value of Poisson's ratio, with correlation coefficient results for the RF model and the DT model being at 0.79 and 0.76 respectively.
Geological setting and gold mineralisation characteristics at the Me Xi, Vinh Linh, Quang Tri, Vietnam
Authors: Le Truong Xuan , Tran Hai Thanh , Zaw Khin , Le Thu Thi ,   Hanoi University of Mining and Geology, Hanoi, Vietnam
 Center for Excellence in Analysis and Experiment, Hanoi University of Mining and Geology, Hanoi, Vietnam
 CODES ARC Centre of Excellence in Ore Deposits, University of Tasmania, Private Bag , Hobart, Tasmania 00, Australia
Published: December 2024

The Me Xi gold deposit is located in Vinh Linh, Quang Tri, Truong Son Fold Belt, Vietnam, about 45 km to the east of the Sepon Mineral District, Laos PDR. Gold mineralisation at Me Xi is predominantly hosted in siltstone and subordinate calcareous siltstone, sandstone, shale, black shale and calcareous shale of Ordovician - Early Silurian Long Dai formation that were metamorphosed at greenschist facies. The igneous rocks that are closest to Me Xi deposit include undated porphyritic dolerite and mafic dykes. Two gold mineralisation zones consisting of eight mineralised bodies have been recorded, in which the main zone is ~ 640 m long and ~10÷60 m wide. The largest gold mineralisation body has a length of ~220 m and a width of ~0.5÷3 m. Gold mineralisation occurred mainly as stockwork quartz-sulphide veins that were typically characterised by the brittle deformation of host rocks. At least four hydrothermal stages were observed at the deposit, of which gold was accumulated in the stage 2 veins and possibly stage 3 veins that has similar mineralogical assemblage and alteration patterns to those of the stage 2. These stockwork stages 2 and 3 veins predominantly consist of pyrite and minor chalcopyrite, gold, arsenopyrite, pyrrhotite and galena in association with strong silicification, chloritisation, sericitisation and subordinate decalcification. The pre-Au stage 1 veins are rarely observed, but this hydrothermal stage records an initial deformation of the host sequence. The post-Au stage 4 is characterised by carbonate-rich quartz stockwork veins with local patches of sulphides.
The initial research results on the improvement of offshore axial pile capacity calculation using CPTu data at block A, offshore Vietnam
Authors: Truong Can Thanh , Le Long Kim , Le Quyen Van ,   Seahorse Marine & Energy JSC, Ba Ria – Vung Tau, Vietnam
  PTSC Geos & Subsea Services Co, Ba Ria – Vung Tau, Vietnam
  Freelance Consultant in Geotechnical Research, Hanoi, Vietnam
Published: December 2024

This paper presents the use of CPTu data in calculation of offshore axial pile capacity based on the CPT-based methods recommended in Appendix C of API RP 2GEO (2014) which are the Simplified ICP-05 Method (Method 1); Offshore UWA-05 Method (Method 2); Fugro-05 Method (Method 3); and NGI-05 Method (Method 4). Formerly, the strength values of cohesionless layers were usually taken from onshore laboratory results or if there were none done, the values were generally assumed based on recommendations of API RP 2A-WSD (2000) standard which often resulted in unconservative axial pile capacity. With the availability of CPTu data which better reflects the in-situ soil conditions, the selection of design parameters for cohesionless layers is improved and consequently, the improved axial capacity calculation both in tension and compression. The improvement in predicted axial pile capacity allows better pile design (for example, choice of pile length, optimization of pile diameter) and hence the economical aspects of the final design at a later design stage. Results from the analyses by CPT-based methods indicate that Method 1, 2 and 3 produce comparable results of capacities in both compression and tension, whereas Method 4 shows somewhat a deviation from the other 3 methods. Hence, a conservative approach to using the capacities calculated by method 4 and especially the API RP 2A-WSD (2000) method should be exercised properly by applying appropriate safety factors.
Human Papilloma Virüsünün Cinsel Fonksiyon Bozukluğuna Etkisi Var Mıdır?
Authors: Gündüz Ceyda Su , Arslan Tarus Hamide , Ölmez Yalazı Rüveyda , Demirci Nurdan
Published: December 2024

Yüksek riskli human papilloma virüslerinin serviks, vulva, vajina, baş ve boyun kanserleri de dahil olmak üzere birçok kanserin gelişme riskini artırdığı bilinmektedir. Kanserlerin yanı sıra, human papilloma virüs enfeksiyonları genital siğiller, infertilite ve cinsel fonksiyon bozukluğuna da neden olabilmektedir. Bu derlemede human papilloma virüsünün cinsel fonksiyon bozukluğuna etkisine yönelik literatür incelenmiştir. Literatür incelemesinde kadınlarda human papilloma virüs testi pozitifliğinin doğrudan cinsel fonksiyonda bozulmaya ya da dolaylı olarak suçluluk, öfke, üzüntü, damgalanma ve utanç gibi duygulara neden olarak cinsel ilgi-istek düzeyinde ve cinsel ilişki sıklığında azalmaya neden olabildiği belirlenmiştir. Bununla birlikte erkeklerde doğrudan prematür ejakülasyon ve erektil disfonksiyon gelişme riskini arttırabildiği ya da dolaylı olarak depresyon, anksiyete, damgalanma ve bulaştırma korkusu gibi duygulara neden olarak cinsel disfonksiyona neden olabildiği görülmüştür. Bu nedenle human papilloma virüsü ile enfekte bireylere bakım veren hemşireler, bireyleri psikolojik ve cinsel fonksiyon açısından değerlendirmeli ve buna yönelik önlemler almalıdır.
Popüler Diyete Bağlı Gelişen Diyabetik Ketoasidoz: Olgu Sunumu
Authors: Özcan Aysel , Çelik Zehra Margot , Yıldız Ergül
Published: December 2024

Tip 1 ve tip 2 Diyabetes Mellitusun ciddi komplikasyonlarından biri olan diyabetik ketoasidozun patofizyolojisinde, insülin yetersizliği sonrası gelişen düzenleyici hormonların birleşik etkileri yer almaktadır. Diyabetik ketoasidoz, hızlı tanı ve tedavi gerektiren kritik bir durumdur. Tedavi hedefleri arasında; sıvı ve elektrolit dengesinin düzeltilmesi, kan gazının, serum glikoz seviyeleri ve osmolaritesinin normal sınırlara getirilmesi, asidoz ve ketozisin düzeltilmesi yer almaktadır. Bu olguda, 57 yaşında erkek tip 2 diyabet hastasının kanıta dayalı öneriler dışında uyguladığı popüler bir diyet olan su diyeti sonrası diyabetik ketoasidoz gelişim süreci ele alınmıştır. Hasta, yatağa bağımlı bir hale gelerek uzun süre hastanede tedavi görmüş ve bu süreçte perkütan endoskopik gastrostomi ile beslenmiştir. Yaklaşık 8 ay boyunca tedavi gören hasta, tedavi gördüğü palyatif bakım servisinde ex olmuştur. Popüler diyetlerin hızlı ağırlık kaybı vaat etmesi ve bilinçsizce uygulanması, özellikle kronik hastalığı olan bireyler için sağlık riskleri oluşturabilir. Bu nedenle, hastaları yanlış seçimlerden korumak için sağlık ve beslenme konularında multidisipliner yaklaşımlar benimsenmeli ve sağlık profesyonelleri birincil bilgi kaynağı olmalıdır.
Kronik Hastalığı Olan Bireylere Bakım Verenlerde Bakım Yükü, İyilik Hali ve Sabır Düzeyleri Arasındaki İlişki
Authors: Kaplan Uyan Tuğçe , Aydınlı Ayşe , Ağralı Hatice
Published: December 2024

Amaç: Bu araştırmanın amacı kronik hastalığı olan bireylere bakım verenlerde bakım yükü, iyilik hali ve sabır düzeyleri arasındaki ilişkinin belirlenmesidir.
Gereç ve Yöntem: Bu araştırma tanımlayıcı ve ilişki arayıcı tipte bir araştırmadır. Araştırmanın evreninin bir kamu hastanesinde tedavi almakta olan hastaların bakım verenleri (n=285) oluşturmuştur. Araştırmamızın verileri, “Kişisel Bilgi Formu”, “Bakım Verme Yükü Ölçeği”, “İyilik Hali Yıldızı Ölçeği” ve “Sabır Ölçeği” ile elde edilmiştir. Araştırmada elde edilen veriler SPSS (Statistical Package for Social Sciences) 20.0 programı kullanılarak analiz edilmiştir.
Bulgular: Bakım verenlerin yaş ortalaması 46.94 ± 15.36 olup, %66.3’ü kadın ve %64.2’si çalışmıyordur. Korelasyon analizi sonucunda Bakım Verme Yükü Ölçeği ile İyilik Hali Yıldızı Ölçeği arasında negatif yönde zayıf ilişki (r=-0.277 p
Women’s Views of Birth Labor Satisfaction Questionnaire: Turkish Validity and Reliability Study
Authors: Altınsoy Büşra , Atilla Rabia , Mecdi Kaydırak Meltem , Oskay Ümran
Published: December 2024

Aim: The purpose of this research was to evaluate the validity and reliability of the Turkish translation of the "Women's Views of Birth Labor Satisfaction Questionnaire (WVBLSQ)", a tool designed to gauge postpartum women's contentment with the birthing experience.
Material and Method: In this methodological study, 320 healthy women who gave birth spontaneously vaginally in the postnatal unit of a state hospital in the Central Anatolia Region of Türkiye participated. The study data were collected between April 2023 and April 2024. The WVBLSQ and the participant introduction form were utilized to gather data. The study's methods included language and content validity, item analysis, test-retest reliability, and exploratory internal consistency coefficients.
Results: The women's average age was 27.09±5.76 years. After the fifth and sixth sub-dimensions were removed from the 26-item version of the scale, Cronbach's alpha value was found to be 0.77 when the reliability of the scale and its seven sub-dimensions were evaluated separately. The sub-dimensions in the scale are ‘Professional support in labour, home assessment at the beginning of labour, expectation of labour, spouse/partner support during labour, control, environment during labour and pain relief’. For each of the scale's sub-dimensions, the Cronbach's α value ranged from 0.26 to 0.75. The results of the test-retest used to assess the scale's temporal invariance revealed that there was a highly significant correlation between the measures.
Conclusion: The Turkish version of the scale proved to be suitable for assessing labor satisfaction in women who had normal spontaneous labor.
Sağlık Hizmetlerinde Süreç Madenciliği Hakkında Bibliyometrik Analiz
Authors: Çelik Ufuk , Yılmaz Özer
Published: December 2024

Amaç: Bu çalışma sağlık hizmetlerinde süreç madenciliği kullanımına yönelik yayınlanmış çalışmaların bibliyometrik analiz yöntemi ile analiz edilerek çalışmaların eğilimini ve literatürün güncel durumunu ortaya koymayı amaçlamaktadır
Gereç ve Yöntem: Veriler Web of Science (WOS) Core Collection, Scopus ve PubMed veri tabanlarında 01.2004-10.2024 tarihleri arasındaki bilimsel çalışmalardan, R programlama dili bibliometrix paketi kullanılarak ve “Process Mining” & “health OR healthcare OR medical OR hospital” araması kullanılarak elde edilmiştir.
Bulgular: Çalışmaya 1002 yayın dahil edilmiştir. 69 farklı ülkeden 2622 farklı yazar tarafından gerçekleştirilen çalışmalarda en üretken ülkeler İtalya, Almanya, Hollanda ve İspanya’dır. En fazla üç yazarlı çalışmaların (n=188) yapıldığı görülmektedir. Çalışmaların %98’i (n=982) İngilizce dilinde yayınlanmıştır. Tüm yayınlarda en çok kullanılan 5 anahtar kelime “sağlık hizmeti, süreç madenciliği, veri madenciliği, süreç modelleri” ve “model” kelimeleridir. Yayınlara en çok katkı sağlayan üniversiteler Leeds (n=89) ve Valensiya Politeknik (n=88) üniversiteleridir. Analize dahil edilen 390 makaleden en çok yayın yapan dergi “Journal of Biomedical Informatics” dergisidir (n=20). İkinci sırada yer alan “International Journal of Environmental Research and Public Health” dergisindeki yayın sayısı ise on beştir.
Sonuç: Çalışma sonucunda sağlık hizmetlerinde süreç madenciliği çalışmalarına olan ilginin özellikle 2016 yılından sonra artışa geçtiğini göstermektedir. Çalışma sonuçlarının kurumların ve sağlık profesyonellerinin süreç madenciliği çalışmalarında iş birliği yapabilmesine yardımcı olacağı düşünülmektedir.
The Future of Education: How Mobile Learning, Microlearning, and Gamification are Revolutionizing Architecture Learning
Authors: Widyakusuma Aryani , Sudibyo Afriq Sarwarana Ramadhan
Published: December 2024

Human education has undergone various cycles of reform, yet many current education systems still rely on rigid models that do not meet the individual needs of students. Along with the advancement of technology and the digital revolution, there is a need for significant changes in the way education is delivered, especially in architectural education. This research aims to explore how mobile learning, microlearning, and gamification can revolutionize architecture education by meeting the increasingly diverse needs of students. This research uses a descriptive methodology that combines case studies and literature reviews to analyze current phenomena in architecture education. Findings show that the implementation of gamification, micro-learning, and mobile learning increases engagement, customization, and flexibility in architecture learning. Students now seek learning experiences that are interactive and customizable to their personal needs. By utilizing AI-based tools and more dynamic learning methods, educators can create learning environments that are more productive and responsive to the demands of the digital age. Architecture education in Indonesia, in particular, needs to adapt to international standards and modern challenges such as environmental sustainability. This research underscores the importance of integrating new technologies in architectural education to create more relevant and effective learning experiences. By adopting a more flexible and technology-driven approach, architecture education can better prepare students to face challenges in the world of work.
Legalization of Marijuana in the Medical Sector: A Criminal Law Perspective
Authors: Amalia Mia , Sandi Chintia , Mulyana Aji
Published: December 2024

Marijuana is a plant that is illegal in Indonesia today. This is regulated in law 35 of 2009 concerning narcotics.2009 on narcotics. Although the use of marijuana is still reaping the pros and cons, one of the followingorganization LGN (lingkat ganja nusantara) is fighting for legalization and expanding to educate the public.educate the public. Marijuana, which is viewed negatively by society, in fact provides many benefits for the medical sector where it is used as a drug.benefits for the medical sector where it is used as an alternative treatment with the doctor's compliance. The conclusion of this study is that the government continues to prohibit the legalization and use of marijuana for medical purposes with the aim of protecting all Indonesian people from new problems that are at risk of arising and to strengthen the government's narrative about marijuana policy for medical purposes requires empirical testing by involving academics to strengthen government policy arguments and clinical trials.
Burning for Science—a Woman in a Technical Field
Authors: Kohse-Höinghaus Katharina
Published: December 2024

Katharina Kohse-Höinghaus was born in Germany’s industrial Ruhr area in 1951. Science fascinated her early on — this never changed and propelled her life into a stellar academic career. After studying chemistry, she cut her own path from atmospheric chemistry to combustion science.
Constantly she created new trails between physics, chemistry, materials science, and engineering to explore combustion, pollutant emissions, and new analytical techniques.
Challenges like a dual-career family and raising funds for cross-border science led to many out-of-the-box initiatives, including science education for kids and students.
Katharina is famous for never running out of fuel: She became the first female President of the International Combustion Society and of Germany’s Bunsen Society, served on numerous boards and received many awards. Her trailblazing life for women in STEM worldwide is remarkable and her engaging story will be enjoyed by all!
Chapter 3: Networks, Organizations, and Participation
Authors: Kohse-Höinghaus Katharina
Published: December 2024

In my academic career, I have been interested not only in research but also in the environment in which creativity, scholarly interaction, and innovation can flourish. Developing an understanding of the mechanics of academic processes on committees and in institutions at the national and international levels has been both labor-intensive and rewarding. Through my participation in such activities, I could question traditional approaches and propose new ones but, for both, I needed adequate exposure to relevant decision-making bodies, an informed background, and an unchallenged scientific standing. Participation in academic governance and functions at various levels provided me with a view of the bigger picture and gave me ideas for change and its implementation. A network suitable for discourse and collaboration and a broad interdisciplinary perspective were key elements for these activities. [...]
Integrated coastal management and marine spatial planning in South African law
Authors: Metuge DN
Published: December 2024

South Africa’s national environmental management instruments, including the Integrated Coastal Management Act, 2008 (‘the NEM: ICMA’), provide statutory mechanisms for achieving cooperative governance in implementing environmental norms. Indeed, the NEM: ICMA provides for establishing integrated coastal management plans within the coastal zone, including South Africa’s coastal waters. In terms thereof, its provisions will prevail in the event of any conflict relating to coastal management. Moreover, the NEM: ICMA only requires that its provisions ‘be read, interpreted and applied in conjunction with the National Environmental Management Act, 1998 [NEMA]’. However, the recently adopted Marine Spatial Planning Act 2018 (MSPA) contains provisions that purport to override the provisions of any other instrument that conflicts with its requirements regarding plans that impact the marine environment. Certainly, it provides that ‘[a]ny right, permit, permission, licence or any other authorisation issued in terms of any other law must be consistent with the approved marine area plans’. This article explores the regulatory overlaps between the NEM: ICMA and the MSPA. It has identified potential areas of conflict with regard to the application of the NEM: ICMA, requirements for the approval of coastal management programmes and the contents thereof, coastal authorisations, coastal use permits, and coastal discharge permits. It confirms that the burden of regulatory consistency with marine spatial planning instruments and approved marine area plans is on other environmental instruments. It concludes with recommendations to prevent regulatory conflicts between the NEM: ICMA and the MSPA.
Driver Drowsiness Detection System for Accident Prevention
Authors: K. Avinash Babu  , G Eswara Rao
Published: December 2024

The abstract highlights the importance of driver drowsiness detection as a critical component of vehicle safety technology, with the goal of preventing accidents brought on by drowsy drivers. According to studies, driver fatigue possibly a factor in 20% of traffic accidents, underscoring the importance of developing efficient accident-avoidance strategies. The research focuses on a particular illustration of an automated tiredness detection system intended to improve driver safety by tracking unsafe driving practices. The primary objective of the research is to develop an automated system capable of accurate analysis the blink patterns of the driver's eyes. It detects modifications to the distance between the eyes and reflects eye blink events using an infrared-based eye blink sensor. The location of the visual is indicated by the sensor's output, which is high when the eye is closed and low when it is open. The project includes a circuit that, in the event that it detects indicators of tiredness, such closed eyes, while driving, sounds an alarm, namely a buzzer next to the driver. By offering a real-time alarm mechanism, this technology seeks to address the risks related to driver weariness and enhance overall road safety.
Arima Model for Gold Price Prediction
Authors: Bottu Rama  , B. Chandrakala  , K. Srujana  , B. Sravanthi
Published: December 2024

Despite increases in 2017 and 2018, the price of gold has been stagnant globally since 2013. The price volatility of gold will significantly influence how people, businesses, and nations choose to invest. This study focuses on the World Gold Council's data for gold prices from Jan 2018 to Feb 2023, and it uses the ARIMA model to forecast and analyze the daily Indian rupee (per ounce) gold price for the month of Feb 2023. The accuracy of models is also estimated in this study using AC, PAC, and BIC. Results from experiments show that ARIMA (4,1,4) is the best model for predicting the Indian price of gold (National Currency Unit per troy ounce). For consumers to comprehend the effectiveness of gold prices and make wise investment decisions, the estimate outcomes of the ARIMA Model are essential.
Kilise-Devlet Çatışmasının Gölgesinde XI. Yüzyıl Papalık Reformu
Authors: Dinleyici Mustafa Furkan
Published: December 2024

Yaklaşık iki bin yıllık bir geçmişe sahip olan Papalık, tarihsel süreç içeri-sinde pek çok dönüm noktası tecrübe etmiştir. Bu dönüm noktalarından biri de XI. yüzyılda gerçekleşen Papalık reformu ya da çoğunlukla kullanılan ismiyle Gregoryan Reform’dur. Bu reformu önemli kılan husus, uzun yıllar-dır Avrupa’da devam eden Kilise-Devlet ilişkisinde bir kırılım yaratması ve bu kırılımın Papalık politikalarında ciddi bir dönüşüm meydana getirmesi-dir. Bu bağlamda, XI. yüzyıl Papalık Reformu’nu ele alan çalışmanın kap-samını; reformun ortaya çıkışını etkileyen tarihsel süreç, reformun Papalık tarafından benimsenmesi ve sistemli bir hale gelmesi ve Papa VII. Grego-rius’un makama gelişiyle birlikte reform sürecinde yaşanan dönüşüm oluş-turmaktadır. Reform sürecinin anlaşılabilmesi adına çalışmada ilk olarak reform öncesi dönemde Papalığın içinde bulunduğu durum ele alınmıştır. Cluny hareketinin ortaya çıkışı ve reforma etkisinden kısaca bahsedilmiş ve reform hareketinin yalnızca ruhban sınıfı tarafından değil keşişler ve halk arasında da benimsendiği gösterilmeye çalışılmıştır. Ardından IX. Leo’nun Papalık makamına gelmesiyle birlikte Kilise’de reformist yaklaşımın yaygın-laşması ve Leo’nun haleflerinin reformu sistemleştirme çabalarında değinil-miştir. Son olarak VII. Gregorius’un Alman İmparatoru IV. Henry ile girdiği mücadele ve bu mücadelenin sonuçlarından bahsedilerek çalışma sonlandı-rılmıştır.
Determining the Usefulness of Land Information Management System (LIMS) in Ending Land Disputes in Zimbabwean A1 Farms
Authors: Agnes Makomo , Masarira T.P
Published: December 2024

This study sought to determine the usefulness of the Land Information Management System (LIMS) for the resolution of Land Disputes in Marondera District A1 resettlement areas. The research was inspired by the continued occurrence of land disputes in Marondera A1 Farms. The main thrust of the research was to determine to assess the usefulness of the LIMS model in ending land disputes in Marondera District A1 farms. The study adopted a mixed research approach hinged on pragmatism research philosophy. A cross-sectional survey research design was used. The research used stratified random sampling for quantitative data whilst purposive sampling was used for the collection of qualitative data. Structured questionnaires and interview guides were the two major instruments that were used. A sample size of 373 participants was drawn from the Department of Lands Marondera, the Zimbabwe Lands Commission, Extension officers, and A1 farmers in areas of Wenimbi, Mushandira, and Ruware in Marondera. The sample size was arrived at using the Raosoft sample size calculator. The sample size for qualitative data was not predetermined but was arrived at using the saturation principle. In the analysis of quantitative data, tables, descriptive statistics, and inferential statistics were produced using Statistical Package for the Social Sciences (SPSS) version 23. The presentation of qualitative data followed a thematic approach in which responses were shown using word cloud analysis. The study revealed that the improved LIMS will enable land registration, land use planning, land dispute resolution, and data analysis and reporting. It was recommended in the study that the government encourage open communication and collaboration among local communities, farmers, and authorities to address grievances and prevent conflicts, fostering a sense of shared responsibility and ownership. Also with LIMS government conducts a thorough audit to identify and resolve issues related to land ownership, boundaries, and usage, helping to prevent future disputes.