bluuebunny/crossref_metadata_2025 huggingface dataset:
Benefits of Elective Para-Aortic Radiotherapy for pN1 Prostate Cancer Using Arc Therapy (Intensity-Modulated or Volumetric Modulated Arc Therapy): Protocol for a Nonrandomized Phase II Trial (Preprint)
Authors: Draulans Cédric , Joniau Steven , Fonteyne Valérie , Delrue Louke , Decaestecker Karel , Everaerts Wouter , Dirix Piet , Van den Bergh Laura , Crijns Wouter , Vandendriessche Hans , Van Wynsberge Lodewijk , Ost Piet , Lumen Nicolaas , Buelens Pieterjan , Haustermans Karin , Berghen Charlien , De Meerleer Gert
Published: June 2018

BACKGROUND

In patients with prostate cancer (PCa) with histopathologically proven pelvic lymph node (LN) metastasis (pN1) after extended pelvic lymph node dissection (ePLND), multimodality treatment consisting of treatment of the primary tumor and whole pelvic radiotherapy (WPRT) combined with androgen deprivation therapy (ADT) offers promising results, leading to better cause-specific survival rates compared with ADT alone. However, in case more than one pelvic LN is invaded by the tumor, approximately 40% of the patients relapse biochemically and clinically. Clinical relapse is present in the para-aortic LNs (M1a disease) in up to 77% of the relapsing cases.

OBJECTIVE

We hypothesize that, based on the evidence that positive LNs represent the door to hematogenous dissemination, elective para-aortic irradiation will reduce the development of both retroperitoneal nodal (M1a) and distant metastasis (M1b or M1c disease), postpone the need for palliative ADT, and prolong the time to castration-refractory disease.

METHODS

To test this hypothesis, we will conduct a prospective, nonrandomized phase II trial to study the efficacy of additional elective para-aortic radiotherapy (PART) in pN1 patients compared with those who were historically treated with adjuvant WPRT alone. We aim to include 137 patients with PCa and presence of pN1 disease after ePLND. With this number of patients, an improvement of 15% in the 5-year clinical relapse-free survival can be detected with a power of 80%.

RESULTS

Recruitment of patients for this trial started in 2017 and will be completed approximately by March 2020.

CONCLUSIONS

This is the first phase II trial to investigate the benefits of an elective PART in patients with PCa. The results of this trial will potentially serve as a sound base for a later randomized phase III trial. All participants are given a PART information sheet and required to give written informed consent. Results are expected to be published in a peer-reviewed journal.

CLINICALTRIAL

ClinicalTrials.gov NCT03079323; https://clinicaltrials.gov/ct2/show/NCT03079323 (Archived by WebCite at http://www.webcitation.org/73ELimv1d)

INTERNATIONAL REGISTERED REPOR

PRR1-10.2196/11256
Exploring Big Data Analytic Approaches to Cancer Blog Text Analysis (Preprint)
Authors: Raghupathi Viju , Zhou Yilu , Raghupathi Wullianallur
Published: June 2018

BACKGROUND

In recent years researchers have begun to realize the value of social media as a source for data that helps us understand health-related phenomena. Health blogs in particular are rich with information for decision-making. While there are web crawlers and blog analysis software that generate statistics related to blogs, these are relatively primitive and are not useful computationally to aid with the analysis and understanding of the social networks and medical blogs that are evolving around healthcare. There is a need for sophisticated tools to fill this gap. Furthermore, to our knowledge there are not many big data studies or applications in the text analytics of cancer blogs. This study attempts to fill this specific gap while analyzing cancer blogs.

OBJECTIVE

In this exploratory research, we examine the potential of applying big data analytic techniques to the analysis of blogs that exist in the cancer domain. Our objective is twofold: to extract from the blogs, patterns and insight about cancer diagnosis, treatment, and management; and to apply advanced computation techniques in processing large amounts of unstructured health data.

METHODS

We applied the big data analytics architecture of Hadoop MapReduce via the Cloudera platform to the analysis of cancer blog content, in order to extract patterns and insight on cancer diagnoses. We apply a series of algorithms to gain insight into the content and develop a vocabulary and taxonomy of keywords based on existing medical nomenclature. By applying a number of algorithms, we gained insight into the blog content. The study identifies, for instance, the most discussed topics as well as associations that relate to key phenomena

RESULTS

Using several text analytic algorithms, including word count, word association, clustering, and classification, we were able to identify and analyze the patterns and keywords in cancer blog postings. This gave insight into some of the key issues that are discussed in blogs such as the type of cancer (breast cancer being the dominant topic), diagnosis, treatments, and others.

CONCLUSIONS

In general, big data analytics has the potential to transform the way practitioners and researchers gain insight from health social media, especially those in free text, unstructured form. Big data analytics and applications in health-related social media are still at an early stage, and rapid acceleration is possible with the advancements in models, tools, and technologies.
Amylolytic ability of bacteria isolated from termite (Coptotermes sp.) gut
Authors: Mulyani Putri Dwi , Hamid Radhiyah Mardhiyah , Janatunaim Rifqi Zahroh , Purwestri Yekti Asih
Published: June 2018

BSR 2, BSR 3, BSR 8, and BSR 9, different bacteria isolated from the termite gut, have been shown to possess cellulolytic activities, but their amylolytic ability has heretofore been unknown. This study attempted to fill in this knowledge gap. The formation of a clear zone using the iodine test showed that the bacteria were able to produce and secrete amylase. Based on the results, the best cultivation times for strains BSR 2, BSR 3, BSR 8, and BSR 9 were 6, 3, 2, and 2 d, respectively, yielding amylase activities of 2.59 ± 0.13 U/mg, 2.00 ± 0.08 U/mg, 1.67 ± 0.10 U/mg, and 1.55 ± 0.12 U/mg, respectively. BSR 2 had the highest amylase activity compared with the other bacterial isolates. The optimum ph for bacterial amylase activity of BSR 2 was 7.0, and the optimum temperature was 40°C. The molecular characterization of isolates BSR 2, BSR 3, BSR 8, and BSR 9 was based on 16S rRNA gene sequences. Isolates BSR 8 and BSR 9 were thus identified as Brevibacillus parabrevis and Brevibacillus sp. With similarities amounting to 92.48% and 95.91%, while the BSR 3 isolate was identified as Pseudomonas alcaligenes with a similarity of 94.29%, and the BSR 2 isolate could not be identified yet.
Isolation of actinomycetes from maize rhizosphere from Kupang, East Nusa Tenggara Province, and evaluation of their antibacterial, antifungal, and extracellular enzyme activity
Authors: Fatmawati Umi , Lestari Yulin , Meryandini Anja , Nawangsih Abdjad Asih , Wahyudi Aris Tri
Published: June 2018

Actinomycetes are the one of the components of the rhizospheric microbial population and useful for producing secondary metabolites such as lytic enzymes, antibiotics, and antifungal. The aim of the study was to isolate the actinomycetes from maize rhizosphere collected from Kupang, East Nusa Tenggara. The screening was focused on the actinomycetes that showed the ability to produce antibacterial, antifungal, and extracellular enzymes such as amylase, cellulase, and protease. The actinomycetes were isolated using Humic-Acid Vitamin B (HV) agar media. The antagonistic assay was tested against Escherichia coli, Staphylococcus aureus, Sclerotium rolfsii and Fusarium oxysporum. Isolate JKP-8 was an isolate that showed the highest activity in inhibiting the growth of E. coli and S. aureus bacteria. Isolate JKP-5 showed the highest activity in inhibiting the growth of F.oxysporum. There were no actinomycetes isolates that showed an ability to inhibit the growth of S. rolfsii fungus based on dual culture assay. JKP-3 and JKP-4 isolates exhibited the highest ability to hydrolyze amylum, while JKP-5 and JKP-8 isolates exhibited the highest ability to hydrolyze CMC. The results of the amplification of 16S rRNA gene in selected potential isolates JKP 5 and JKP 8 indicated that both isolates belong to the genus Streptomyces.
Use of microsatellite markers to detect heterozygosity in an F2 generation of a black rice and white rice cross
Authors: Kristamtini Kristamtini , Taryono Taryono , Basunanda Panjisakti , Murti Rudi Hari
Published: June 2018

The aim of this research was to know the heterozygosity of F2  generation from black rice and white rice crossing using microsatellite marker.  The research material consisted of F2 Sx G plant population from black rice (S) and white rice Situbagendit (G) crosses, female parent of black rice (S), male parent of white rice (G), chemical and organic fertilizer, chemicals and tools for molecular activity and 3 microsatellite markers related to color properties  (RM 220, RM 224 and RM 252). All of plant populations (generation F2, parent female, parent male) were planted in fields up to harvest. Young leaves (30 days after planting) all of plant populations were molecularly analyzed using 3 microsatellite markers (RM 220, RM 224 and RM 252). Stages of this activity include DNA isolation, PCR reaction, and visualization of PCR results using Metaphore Agarose Gel Electrophoresis. The results showed that the percentage of the number of individual plants showing heterozygous pattern in F2 S × G plant generation was 50% (RM 220); 40% (RM 224) and 60% (RM 252), so the RM 252 microsatellite marker was effectively used as a DNA-assisted selection tool on the crossbreed of black rice with white rice.
Infraestructura carretera y economía regional. El caso de los productores de ajo de Oaxaca y Puebla
Authors: Tapia Guerrero Luis Arturo
Published: June 2018

En este artículo se analiza la relación entre infraestructura carretera y desarrollo regional, a través del estudio de caso de la crisis del ajo oaxaqueño. Mediante la revisión de los datos de infraestructura carretera y agropecuarios, se propone que esta crisis se ha configurado en el marco de un incremento en la accesibilidad carretera, que abrió Oaxaca a mayores intercambios comerciales con la región, en especial con Puebla. Esto generó un reacomodo de los agentes económicos según sus capacidades productivas, y una multiplicación de efectos no esperados, sobre todo el desplazamiento comercial o la reclusión a la subsistencia de los productores sin capacidad para competir y enfrentados a una economía estatal incapaz de absorberlos.
Identidades em Reinvenção: O Fortalecimento Coletivo de Estudantes Indígenas no Meio Universitário
Authors: Viana Iclicia , Maheirie Kátia
Published: June 2018

A presença indígena nos espaços acadêmicos tem crescido nos últimos anos, especialmente por conta das politicas de ação afirmativa. A entrada neste universo - espaços historicamente brancos e elitizados - tem produzido fissuras no olhar estereotipado construído sobre povos indígenas e, ao mesmo tempo, tem visibilizado os preconceitos e racismos de nossa sociedade. Neste cenário, a formação superior tem sido reivindicada, cada dia mais, como instrumento de luta necessário para o fortalecimento dos movimentos indígenas. Este texto discute aspectos gerais da presença indígena nas universidades brasileiras, bem como a potência na reinvenção identitária e no fortalecimento de coletivos, marcando a universidade como um novo território de fronteira e de luta que afeta e é afetada pelos povos indígenas. Palavras chave: povos indígenas –– políticas de ação afirmativa – identidade – psicologia e povos indígenas.
A Relação Profissionais de Saúde - Usuários do SUS: Problematizando o Termo "Ajuda"
Authors: Rodrigues Isabela Tellis , Moreira Janine
Published: June 2018

As relações de poder dentro de uma Estratégia de Saúde da Família (ESF) são reflexos das relações de poder na sociedade, variando de acordo com a formação de cada profissional e, consequentemente, com o status social e acadêmico que cada profissão “detém”. Na equipe mínima da ESF, a medicina está no topo da hierarquia, seguida pelas demais profissões, ainda em uma lógica biologicista e hospitalocêntrica. “Dizer a palavra” ou silenciar está diretamente relacionado com o status profissional. Essa lógica presente na relação entre os profissionais é reproduzida na relação com usuários do serviço.  Para superar essa condição, se faz necessário assumir uma posição de dialogicidade nesses espaços, problematizando a “lógica de ajuda”, a qual advém da lógica da compaixão, e que esconde uma noção de superioridade da equipe profissional, e instalando-se, em seu lugar, a lógica da solidariedade, a qual só é possível a partir da corresponsabilização da saúde.
Entre Saúde Mental e a Escola: a Gestão Autônoma da Medicação
Authors: Chaves Felipe Alan Mendes , Caliman Luciana Vieira
Published: June 2018

Quando nos referimos a um trabalho em Saúde Mental com crianças e adolescentes, é quase inevitável não nos deparar com os atravessamentos do universo escolar. Não poucas vezes os encaminhamentos de crianças para os serviços de saúde mental envolvem os ditos problemas de aprendizagem e a demanda por medicamentos e laudos, principalmente os relacionados ao Transtorno de Déficit de Atenção e Hiperatividade (TDAH). Neste artigo, esboçamos considerações sobre as práticas produzidas no entrecruzamento da Saúde Mental e a escola resultantes de uma pesquisa-intervenção que objetivou cartografar tais articulações e as pistas para construir um trabalho intersetorial. Para tanto, acompanhamos um grupo de Gestão Autônoma da Medicação (GAM), composto por pesquisadores, familiares de crianças em tratamento com psicotrópicos e trabalhadores do Centro de Atenção Psicossocial para infância e Adolescência de Vitória/ES (CAPSi).
Editorial - Investigar, Intervir, Inventar: Do Imprescindível entre Saúde Mental e Atenção Básica
Authors: Paulon Simone Mainieri , Londero Mário Francis Petry , Righi Liane Beatriz
Published: June 2018

Editorial
Cartografia e Hermenêutica nos Enlaces da Pesquisa Participativa / Interlacings of Cartography and Hermeneutics in Participatory Research
Authors: Righi Liane Beatriz , Gonçalves Cristiane Holzschuh
Published: June 2018

Avaliação de Quarta Geração e Método Cartográfico têm sido referências importantes para pesquisas no campo da saúde mental, mas são poucos os registros de suas conexões. A análise da investigação “Qualificação da Saúde Mental na Atenção Básica” visa contribuir para discutir características que a composição entre os dois referenciais metodológicos pode imprimir às pesquisas deste campo. A maneira como a investigação conectou os dois referenciais resultou em ampliação da participação.Palavras-chave: Avaliação; Pesquisa Qualitativa; Cartografia; Saúde Mental; Atenção Primária em Saúde.
E se nós fossemos Jacques Rivière? / What if we were Jacques Rivière?
Authors: Correa-Urquiza Martin
Published: June 2018

A relação epistolar entre Antonin Artaud e seu editor, Jacques Rivière, sugere neste artigo a possibilidade de uma outra maneira de se relacionar com a chamada loucura. Propõe uma visão que permite um freio para a patologização constante das identidades sociais no campo da saúde mental. Para Rivière, Artaud era antes poeta do que louco; escritor antes que sujeito da loucura, e a partir daí o interpela, o acompanha. O editor aparece, então, como um tipo de gentil provocador, um hipocrático literário, um gerador de novos contextos de possibilidades, de canais para o fluir criativo de Artaud. E foi precisamente esse fluir acompanhado, o que mais tarde permitiria ao poeta francés, conseguir uma relativa recuperação. O artigo é apresentado como um breve ensaio teórico a partir do qual propõe a possível exploração de outras formas de se relacionar com a questão do sofrimento psíquico e da saúde mental.Palavras-chave: Loucura; Artaud; Despatologização; Identidade; Saúde Mental.
CHARACTERISTICS OF MEAT PRODUCTIIVITY OF CHUB, SQUALIUS CEPHALUS (L., 1758) FROM UPPER AKCAY RIVER, BUYUK MENDERES BASIN (TURKEY)
Authors: Sasi Huseyin , Saidu Mohammed
Published: June 2018

The meat productivity of
chub (Squalius cephalus) and
the relationship between various organs of the body were determine  after catching 153 fish samples from upper
Akcay River, South Aegean Region between June 2012 and May 2013.  In this study, the following results are
obtained; percentage of head weight 16.00%, visceral weight 9.90%, fins weigh
6.30% and Meat productivity 67.10%. 
Depending on their age between I and VII, chub population meat
efficiency percent was determined as 64.44; 66.86; 70.63; 71.73; 71.31; 71.01
and 67.60 respectively. These results show that meat production increased as
the age increases. It was later proposed to catch fish that have reach maturity
age and are larger than 16,20cm length. Results showed that meat productivity  of fish was increased  after age 
V. in this river.
NEW RECORD OF THE KIZILIRMAK KILLIFISH (Aphanius marassantensis Pfleiderer, Geiger & Herder, 2014) FROM SÜREYYABEY DAM LAKE IN YEŞİLIRMAK BASIN
Authors: Benzer Semra
Published: June 2018

The aim of this was to quantify morphometries
characteristic of Aphanius marassantensis from Süreyyabey Dam Lake in
2016.  Some morphometric characters of
samples were measured. These characteristics were standard length (SL), total
length (TL) body weight (W), head length, preorbital distance, eye diameter,
postorbital distance, head depth, predorsal distance, prepelvic distance,
preanal distance, pectoral fin - pelvic fin distance,  pelvic fin - anal fin distance, body depth,
dorsal fin (anterior end) – anal fin distance, dorsal fin (posterior end) –
anal fin distance, postdorsal distance, postanal distance, caudal peduncle
length (dorsal),  caudal peduncle length
(ventral),  caudal peduncle depth, dorsal
fin base length, anal fin base length, pectoral fin length,  pelvic fin length, dorsal fin length, anal
fin length. The SL of 100 individuals ranged from 20 to 38 mm. The TL of individuals
were between 28 and 45 mm, and W ranged between 0.37 and 1.91 g.
Electrochemical oxidation of carbon monoxide: From platinum single crystals to low temperature fuel cells catalysts. Part I: Carbon monoxide oxidation onto low index platinum single crystals
Authors: Grgur Branimir , Markovic Nenad , Lucas Chriss , Ross Philip
Published: June 2018

The electrochemical oxidation of carbon monoxide and the interfacial
structure of the CO adlayer (COads) on platinum low index single crystals,
Pt(111), Pt(100) and two reconstruction of Pt(110), were examined using the
rotation disk electrode method in combination with the in situ surface X-ray
diffraction scattering technique. The mechanism of CO oxidation is discussed
on the basis of the findings that, depending on the potential, two energetic
states ofCOads exist on the platinum surfaces. Thus, at lower potentials,
weakly bonded states (COads,w) and at higher potentials strongly bonded
states (COads,s) are formed. The mechanism of the oxidation of
hydrogen-carbon monoxide mixtures is also proposed.
The effect of organic molecules adsorption on hydrogen absorption in relation to the hydrogen evolution reaction
Authors: Vracar Ljiljana
Published: June 2018

The competitive adsorption of organic molecules (2,7-naphthalenedisulfonic
acid) and adsorbed His of interest in relation to its influence on H absorption
into a Pd-Ni electrodeposited alloy. The experimental results, in acid
solution, show an enhancement of the coverage of the electrode surface with
adsorbed H due to the competitive adsorption of organic molecules that
interfere with H atoms, through lateral attractive interactions between the
adsorbed species and communal electronic effects, leading supposedly to a
decreased probability of H entry into the alloy. Chemisorbed H is, on the
other hand, an intermediate in the HER, so the enhancement of the electrode
coverage in the presence of co-adsorbed organic molecules promotes the
hydrogen evolution reaction.
The effect of the composition of the dispersing medium of oxide sols on the electrocatalytic activity of sol-gel obtained RuO2-TiO2/Ti anodes
Authors: Mitrovic Dejan , Panic Vladimir , Dekanski Aleksandar , Milonjic Slobodan , Atanasoski Radoslav , Nikolic Branislav
Published: June 2018

The influence of the addition of methanol, ethanol, 1-propanol and 2-propanol
to the dispersing medium of amixture of RuO2 and TiO2 sols on the
electrochemically active surface area for proton exchange, as well as on the
electrocatalytic activity for the chlorine evolution reaction (CER) of
RuO2-TiO2/Ti electrode obtained by sol-gel procedure was investigated. The
electrochemically active surface area was examined by cyclic voltammetry,
while the analysis of the activity for the CER was performed by polarization
measurements. The stability of the obtained anode coatings was also checked
by an accelerated stability test. The anode properties depend on the number
of C atoms in the alcohol molecule, as well as on the elapsed time between
the preparation of the sols/alcohol mixture and its application onto the
titanium support. The addition of alcohol increased the activity of the
anodes for the CER, compared to those prepared without the addition, but
their stability was smaller.
Electrochemical properties and thermal stability of epoxy coatings electrodeposited on aluminium and modified aluminium surfaces
Authors: Miskovic-Stankovic Vesna , Lazarevic Zorica , Kacarevic-Popovic Zorica
Published: June 2018

The corrosion behaviour of epoxy coatings electrodeposited on aluminium, as
well as on electrochemically and chemically modified aluminium were
investigated during exposure to 3 % NaCl. Electrochemical impedance
spectroscopy (EIS) and thermogravimetric analysis (TGA) were used for the
determination of the protective properties of epoxy coatings on aluminium,
anodized aluminium, phosphatized and chromatized-phosphatized aluminium. The
protective properties of epoxy coatings on anodized and
chromatized-phosphatized aluminium are significantly improved with respect
to the same epoxy coatings on aluminium and phosphatized aluminium: higher
values of the pore resitance and charge-transfer resistance, lower values of
the coating capacitance, double-layer capacitance and relative permittivity
(from EIS) smaller amount of absorbed water inside the coating (From TGA).
On the other hand, the lower values of the ipdt temperature indicate a lower
thermal stability of the epoxy coatings on anodized and
chromatized-phosphatized aluminium.
New methods of controlled monolayer-to-multilayer deposition of Pt for designing electrocatalysts at an atomic level
Authors: Brankovic S.R. , Wang J.X. , Adzic R.R.
Published: June 2018

Two new methods for monolayer-to-multileyer Pt deposition are presented. One
involves Pt deposition by the replacement of an UPD metal monolayer on an
electrode surface and the other the spontaneous deposition of Pt on Ru. The
first method, exemplified by the replacement of a Cu monolayer on a Au(111)
surface, occurs as a spontaneous irreversible redox reaction in which the Cu
monolayer is oxidized by Pt cations, which are reduced and simultaneously
deposited. The second method is illustrated by the deposition of Pt on a
Ru(0001) surface and on carbon-supported Ru nanoparticles. This deposition
takes place upon immersion of a UHV-prepared Ru(0001) crystal or Ru
nanoparticles, reduced in H2, in a solution containing PtCl6 2- ions. The
oxidation of Ru to RuOH by a local cell mechanism appears to be coupled with
Pt deposition. This method facilitates the design of active Pt-Ru catalysts
with ultimately low Pt loadings. Only a quarter of a monolayer of Pt on Ru
nanoparticles yields an electrocatalyst with higher activity and CO
tolerance for H2/CO oxidation than commercial Pt-Ru alloy electrocatalysts
with considerably higher Pt loadings.
Copper electrodeposition from a copper acid baths in the presence of PEG and NaCl
Authors: Jovic V.D. , Jovic B.M.
Published: June 2018

Copper electrodeposition from copper acid solutions containing PEG and NaCl
has been investigated onto Cu(111), Cu(100) and polycrystalline copper
electrodes using polarization and EIS measurements. The adsorption of
sulphate and chloride anions, and PEG molecules, was investigated onto
Cu(111) and Cu(100) by cyclic voltammetry and differential capacitance
measurements. Differential capacitance vs. potential curves recorded onto
Cu(100) in solutions containing 0.1 M H2SO4, 0.1 M H2SO4 + 10-3 M PEG and
0.1MH2SO4 + 10-3MPEG + 10-3MNaCl confirm that ?specific adsorption?
of PEG molecules occurs in the absence of NaCl in the solution, in the
potential region of copper electrodeposition, e.g., between -1.0 V and -0.5
V vs. SSE. In the presence of chloride ions, the adsorption of PEG molecules
is suppressed and there is no evidence of adsorption of neutral PEG
molecules. It is shown that hysteresis, appearing on the polarization curves
of copper electrodeposition, is not a consequence of competition between
inhibition provided by the Cl-PEG/Cu2+/Cu+/Cu interface and the catalytic
effects of Cl-MPSA/Cu2+/Cu+/Cu interaction, because hysteresis is present in
the solution containing only PEG and NaCl, e.g., in the absence of MPSA. EIS
measurements confirm the simultaneous occurrence of two processes during
copper electrodeposition: deposition of copper by discharge of Cu2+ ions and
?specific adsorption? and discharge of some heavily charged species, most
probably containing Cu, PEG and Cl.
Operation time and intraoperative fluoroscopy time in different internal fixation methods for subtrochanteric fractures treatment
Authors: Mitkovic Milan , Milenkovic Sasa , Micic Ivan , Kostic Igor , Stojiljkovic Predrag , Mitkovic Milorad
Published: June 2018

Introduction/Objective. Subtrochanteric fractures are unstable, tending to a varus, antecurvatum, and shortening deformity. The aim of this paper was to compare operation time and fluoroscopy time between different internal fixation methods in the treatment of subtrochanteric fractures. Method. The prospective study of the group of 27 patients with a subtrochanteric fracture treated by the SIF (selfdynamisable internal fixator with a trochanteric unit) method had been done. Operation time and fluoroscopy time values from this group were compared to the same parameters data from the literature for intramedullary (IM) nails, proximal femur locking plates (PF-LCP), dynamic condylar screws (DCS), and the 95?-angled blade plate. Results. In the SIF group, operation time was 62.2 (25?140) minutes and fluoroscopy time was 43 (20?95) s. Average operation time from the literature data was: 102.1 (43?181) minutes for IM nail, 94.2 (75?129) minutes for PF-LCP, 105.3 (70?166) minutes for DCS and 221.5 (171?272) minutes for blade plate. Average fluoroscopy time from the literature data was: 109.6 (34?250) seconds for IM nail, 102.3 (47?180) seconds for PF-LCP, 238 seconds for DCS. Operation time and intraoperative fluoroscopy time were higher in IM nail, PF-LCP, DCS and blade plate comparing to SIF method (p < 0.05). Conclusion. The above mentioned difference could be explained by a degree of required accuracy in the initial operative technique maneuvers, by used number of screws and by the type of the fracture reduction performance in different fixation methods. Operation time during IM nailing of subtrochanteric fractures sometimes can be shorter than average operation time in SIF method, what could be explained by the skill of the surgeon to perform as fast closed reduction for insertion of guide wire.
The Common HNF1A Variant I27L Is a Modifier of Age at Diabetes Diagnosis in Individuals With HNF1A-MODY
Authors: Locke Jonathan M. , Saint-Martin Cécile , Laver Thomas W. , Patel Kashyap A. , Wood Andrew R. , Sharp Seth A. , Ellard Sian , Bellanné-Chantelot Christine , Hattersley Andrew T. , Harries Lorna W. , Weedon Michael N.
Published: June 2018

There is wide variation in the age at diagnosis of diabetes in individuals with maturity-onset diabetes of the young (MODY) due to a mutation in the HNF1A gene. We hypothesized that common variants at the HNF1A locus (rs1169288 [I27L], rs1800574 [A98V]), which are associated with type 2 diabetes susceptibility, may modify age at diabetes diagnosis in individuals with HNF1A-MODY. Meta-analysis of two independent cohorts, comprising 781 individuals with HNF1A-MODY, found no significant associations between genotype and age at diagnosis. However after stratifying according to type of mutation (protein-truncating variant [PTV] or missense), we found each 27L allele to be associated with a 1.6-year decrease (95% CI −2.6, −0.7) in age at diagnosis, specifically in the subset (n = 444) of individuals with a PTV. The effect size was similar and significant across the two independent cohorts of individuals with HNF1A-MODY. We report a robust genetic modifier of HNF1A-MODY age at diagnosis that further illustrates the strong effect of genetic variation within HNF1A upon diabetes phenotype.
Effect of Empagliflozin on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial (E-LIFT Trial)
Authors: Kuchay Mohammad Shafi , Krishan Sonal , Mishra Sunil Kumar , Farooqui Khalid Jamal , Singh Manish Kumar , Wasir Jasjeet Singh , Bansal Beena , Kaur Parjeet , Jevalikar Ganesh , Gill Harmendeep Kaur , Choudhary Narendra Singh , Mithal Ambrish
Published: June 2018

OBJECTIVE

Sodium–glucose cotransporter 2 (SGLT-2) inhibitors have been shown to reduce liver fat in rodent models. Data regarding the effect of SGLT-2 inhibitors on human liver fat are scarce. This study examined the effect of empagliflozin (an SGLT-2 inhibitor) on liver fat in patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) by using MRI-derived proton density fat fraction (MRI-PDFF).

RESEARCH DESIGN AND METHODS

Fifty patients with type 2 diabetes and NAFLD were randomly assigned to either the empagliflozin group (standard treatment for type 2 diabetes plus empagliflozin 10 mg daily) or the control group (standard treatment without empagliflozin) for 20 weeks. Change in liver fat was measured by MRI-PDFF. Secondary outcome measures were change in alanine transaminase (ALT), aspartate transaminase (AST), and γ-glutamyl transferase (GGT) levels.

RESULTS

When included in the standard treatment for type 2 diabetes, empagliflozin was significantly better at reducing liver fat (mean MRI-PDFF difference between the empagliflozin and control groups −4.0%; P < 0.0001). Compared with baseline, significant reduction was found in the end-of-treatment MRI-PDFF for the empagliflozin group (16.2% to 11.3%; P < 0.0001) and a nonsignificant change was found in the control group (16.4% to 15.5%; P = 0.057). The two groups showed a significant difference for change in serum ALT level (P = 0.005) and nonsignificant differences for AST (P = 0.212) and GGT (P = 0.057) levels.

CONCLUSIONS

When included in the standard treatment for type 2 diabetes, empagliflozin reduces liver fat and improves ALT levels in patients with type 2 diabetes and NAFLD.
Quality investigation of alumina ceramic laser cutting based on vapor-to-melt ratio
Authors: Luo Yonghao , Wang Xuyue , Wu Di
Published: June 2018

In order to reveal the relationship between vapor-to-melt ratio and processing quality in pulsed laser cutting of alumina ceramic sheets, experiments are carried out to obtain variations of the vapor-to-melt ratio with laser power, scanning speed, and thickness of ceramic sheet. By the morphological observation and analysis, the influence of the vapor-to-melt ratio on cutting quality is summarized. It is found that the vapor-to-melt ratio is increased with the increase of laser power, while it is decreased with the increase of scanning speed and the increase of sheet thickness. A good processing quality with suitable kerfs' width, better uniformity, and smaller roughness is obtained at a relatively large value of vapor-to-melt ratio. However, the excessive vapor-to-melt ratio will cause the deterioration of cutting stability and quality. Therefore, to meet the requirement, the vapor-to-melt ratio is controlled at around 0.1 to get 250 μm of average kerfs' width and Ra less than 3.2 μm of uniform kerfs. It reveals that the vapor-to-melt ratio is more intuitive to reflect the connection between the forms of material removal and cutting quality in laser processing, which provides an important theoretical and experimental support in the field of precision laser cutting on alumina ceramic sheets.
Picosecond laser micro-drilling, engraving and surface texturing of tungsten carbide
Authors: Wang Xincai , Zheng Hongyu
Published: June 2018

The results on picosecond laser micro-drilling, engraving, and surface texturing of tungsten carbide (WC) substrate are presented. A systematic study was conducted on the influence of various laser parameters on the characteristics of laser machined features. The machined features such as micro-holes, engraved structures, and surface textures were evaluated with an optical microscope, scanning electron microscope/energy dispersive x-ray spectrometer. Under the identified optimum laser parameters, high quality different sized holes, engraved structures, and two-scale (micro/nano) surface textures on WC substrates were produced. The developed process has potential to be applied in the manufacturing of WC substrate based components for precision engineering industry.
Laser-based plastic-metal-joining with self-organizing microstructures considering different load directions
Authors: van der Straeten Kira , Olowinsky Alexander , Gillner Arnold
Published: June 2018

Innovative multi-material lightweight construction enables reducing dead weight while maintaining and preferably boosting the components' performance. The implementation of multi-material parts (e.g., plastic-metal-components) requires reliable joining processes since a direct connection between these materials is not feasible due to their different physical and chemical properties. In order to avoid additional weight through adhesive bonding, riveting or fasteners, thermal direct joining with a modified metal surface is a promising approach. Within a first process step, the metal surface is modified by laser-microstructuring. To enlarge the boundary surface and create undercut structures, random self-organizing micro- and nanostructures are generated with ultrashort pulsed laser radiation on stainless steel samples. In the subsequent direct thermal joining process, both joining partners are clamped together. The metal is heated up with diode laser radiation, and through heat conduction, the polymer melts and flows into the generated cavities. After cooling-down, a firm joint between both materials is created, which is based on mechanical interlocking and increased specific adhesion between the joining partners. The mechanical strength of the joint depends strongly on the load direction. In the presented contribution, the strength of the joint between stainless steel and glass-fiber-reinforced and non-reinforced thermoplastics (PP) is investigated for three different load directions (tensile shear, tensile and peel).
Analysis of the interaction between the temperature field and the weld seam morphology in laser transmission welding by using two different discrete laser wavelengths
Authors: Geißler Bastian , Laumer Tobias , Wübbeke Andrea , Lakemeyer Patrick , Frick Thomas , Schöppner Volker , Schmidt Michael
Published: June 2018

Laser transmission welding is a non-contact and efficient process technology for joining thermoplastic polymers. In the conventional process, laser sources in the wavelength range of 1 μm are usually used. Therefore, most of the laser radiation is transmitted through the upper joining partner and absorbed only in the lower joining partner. As a result, the possibilities to influence the temperature field especially in the upper joining partner are limited. To overcome these limitations, an additional thulium fiber-laser with a wavelength of 1.94 μm is used in this study and coaxially aligned with a diode laser. The use of an additional thulium fiber-laser leads to a significant absorption in the upper joining partner. Through this approach, it is shown that the temperature field and the weld seam geometry can be influenced by using these two different discrete laser wavelengths. Depending on the intensity distribution of both lasers, an increase of the size of the heat affected zone in the upper joining partner can be observed. In order to develop a better process understanding, a thermal finite element model is built up and verified by comparing the calculated size of the heat affected zone for different process parameters with the experimental data. The model is able to represent the influence of both laser sources on the temperature field and is used to calculate characteristics of the temperature field, such as maximum temperatures or cooling rates. The characteristics are then used to explain the weld seam morphology, such as occurrence and size of spherulitic structures in the weld seam.
Tendances canadiennes en matière de mortalité liée aux opioïdes et d’invalidité découlant d’un trouble de
consommation d’opioïdes, à la lumière de l’Étude sur la charge mondiale de morbidité (1990-2014)
Authors: Orpana Heather M. , Lang Justin J. , Baxi Maulik , Halverson Jessica , Kozloff Nicole , Cahill Leah , Alam Samiah , Patten Scott , Morrison Howard
Published: June 2018

Introduction

Plusieurs régions du Canada ont récemment connu de brusques hausses de
surdoses d’opioïdes ainsi que des hospitalisations et des décès connexes. Cet article traite
de la mortalité liée aux opioïdes et de l'invalidité découlant d'un trouble de consommation
d’opioïdes au Canada entre 1990 et 2014, à la lumière des données de l’Étude sur la
charge mondiale de morbidité (ÉCMM).

Méthodologie

Nous avons utilisé les données de l’ÉCMM pour décrire l'évolution (1990
à 2014) en matière de mortalité liée aux opioïdes et d’invalidité découlant d’un trouble de
consommation d’opioïdes en calculant les années de vie ajustées du facteur invalidité
(AVAI), les décès, les années de vie perdues (AVP) et les années vécues avec invalidité
(AVI). Nous avons également comparé les taux d’AVP et d’AVAI pour 100 000 au Canada,
aux États-Unis et dans d'autres régions.

Résultats

Le taux normalisé selon l’âge d’AVAI lié aux opioïdes au Canada était de 355,5
par 100 000 en 2014, soit un taux supérieur au taux mondial de 193,2 mais inférieur au
taux de 767,9 aux États-Unis. Entre 1990 et 2014, le taux normalisé selon l’âge d’AVP
attribuables aux opioïdes a augmenté de 142,2 % au Canada alors qu’il a diminué de
10,1 % à l’échelle mondiale. Les AVI ont contribué à une plus grande proportion du
fardeau global lié aux opioïdes que les AVP, et ce, dans tous les groupes d’âge. La perte de
santé a été plus importante chez les hommes que chez les femmes, et particulièrement
marquée chez les 25 à 29 ans.

Conclusion

Le fardeau sur la santé dû à la mortalité liée aux opioïdes et à l’invalidité
découlant d’un trouble de consommation d’opioïdes au Canada est important et s’est
considérablement alourdi entre 1990 et 2014. Ces données révèlent la nécessité d’agir en
santé publique, notamment par le renforcement de la surveillance des divers méfaits liés
aux opioïdes.
At-a-glance - Hospitalizations and emergency department visits due to opioid poisoning in Canada
Authors: O’Connor Shannon , Grywacheski Vera , Louie Krista
Published: June 2018

The rise in opioid-related harms is an issue of increasing public health importance in
Canada. This analysis used data from the Hospital Morbidity Database and the National
Ambulatory Care Reporting System to determine the number of opioid poisoning hospitalizations
and emergency department visits in Canada. Opioid poisoning hospitalizations
have increased over the past 10 years, reaching 15.6 per 100 000 population in
2016/17. Emergency department visits due to opioid poisoning have also increased in
Alberta and Ontario, the two provinces that collect emergency department data at the
level of detail required for this analysis. These findings highlight the importance of pan-
Canadian surveillance of opioid-related harms, as well as the need for evidence-based
policies to help reduce these harms.
At-a-glance - Impact of drug overdose-related deaths on life expectancy at birth in British Columbia
Authors: Ye Xibiao , Sutherland Jenny , Henry Bonnie , Tyndall Mark , Kendall Perry Robert William
Published: June 2018

We quantified the contributions of leading causes of death and drug overdose to changes
in life expectancy at birth over time and inequalities by sex and socioeconomic status in
British Columbia. From 2014 to 2016, life expectancy at birth declined by 0.38 years and
drug overdose deaths (mainly opioid-involved) contributed a loss of 0.12 years of the
decrease. The analysis also demonstrated that the higher drug overdose mortality
among males and among those in lower socioeconomic status communities contributed
to a differential decrease in life expectancy at birth for males and for those in the latter
category.
Emoticonların İletişim Aracı Olarak Kullanılmasına Yönelik Öğrenci Tutumlarının İncelenmesi
Authors: SÖNMEZ Hülya
Published: June 2018

Bu
çalışmada öğrencilerin duygu ve düşüncelerini yazılı olarak ifade etmek için
sıklıkla kullandığı emoticonlara yönelik tutumları incelenmiştir. Yapılan
literatür taraması sonucunda emoticonların son zamanlarda araştırmacıların
dikkatini çekse de bu konunun birçok yönden hâlâ araştırılması gerektiği
belirlenmiştir. Özellikle eğitimde
emoticonların yeri ve öneminin tam olarak aydınlatılmaması bu çalışmayı daha elzem
kılmıştır. Öğrencilerin okul içinde ve dışında kullandıkları emoticonlara
yönelik tutumları belirlemek amacıyla “Anlamlı Suratları (Emoticon) Kullanma
Tutum Ölçeği” (ASK TO)
geliştirildi. Konu alanı uzmanları ve ölçme değerlendirme uzmanlarının görüş ve
önerileriyle tamamlanan ölçeğin pilot uygulaması elli öğrenci ile yapıldı.
Bunun sonucunda gözden geçirilen ölçek ve eki, sekizinci sınıfta eğitim-öğretim
gören 297 öğrenciye uygulandı. Toplanan veriler SPSS 17 istatistik programında
analiz edilerek ölçeğin geçerlilik, güvenirlik ve faktör analizleri yapıldı.
Yapılan güvenirlik analizi sonucunda ölçeğin Cronbach's Alpha değeri (,844)
olarak belirlenmiş olup; ölçeğin oldukça güvenilir olduğu saptandı. Faktör
analizinde ise KMO (,872)  ve Barlet testi (p= ,000)  anlamlı
bulunarak
faktör homojenliğinin iyi olduğu belirlenmiştir. Araştırmanın sonunda
öğrencilerin emoticonlarla ilgili tutumlarının olumlu olduğu belirlenmiştir. Bu
bulgu sonucunda emoticonların eğitimde yararlı ve etkili bir araç olarak nasıl
kullanılacağı önerilmiştir.
Introduction
Authors: Almeida Fábio Ferreira
Published: June 2018

Georges Canguilhem – Dossier
The Birth of the Clinic and the Sources of Archaeological History
Authors: Delaporte François
Published: June 2018

The year 2013 marked the 50th anniversary of the publication of a classic of the historiography of sciences, Michel Foucault’s The birth of the clinic: An archaeology of medical gaze. In different parts of the world, events were organized to reflect on this important work. The article argues that if one cannot draw a direct line linking the work of the leading historians-philosophers of the twentieth-century sciences in France to Michel Foucault’s archaeological study of the clinic, we must recognize that the author of The Birth of the Clinic has taken up from these historians-philosophers the methodological and conceptual tools that made it possible to study the history of science and knowledge in a new way.
Wassup! Methamphetamine
Authors: Manuel Carmen
Published: June 2018

Defying the odds of methamphetamine (P)…The kaupapa is eXpressed through the lenses of personal eXperiences of an independent Māori wahine and the impacts these eXperiences have had on my life. To understand this unique journey of resilience in restoration of my mana and wairua I had to go back to my roots. In Te Ao Maori I found our whanau “TriX of the Trade” a modern platform with 3 interactive Kaitiaki; Whakapapa, Whakakoha and Whakamana. We call this Taonga Tuku Iho, knowledge passed down through generations to get us by. Once acknowledged connections to the healing process began “Taitimu Taiaha – The turning of tides, flipping the script and moving with the times”. The struggle makes us stronger giving us a stauncher positioning “Kia mau tonu tou mauri - Keepn it Real”
Medical Anthropology – New Paradigms, New Limits
Authors: BĂRBULESCU Elena
Published: June 2018

This study provides a short review of a new field emerging in Romanian anthropology research – medical anthropology. After presenting a short description of the influences in the history of this field during the past seven decades in the western academic field, the author describes the origins and the trajectory this field has taken in Romania in the period after 1989, when the political regime changed. The paper shows that even if the concerns in medical anthropology are not entirely new, the emerging shape of the field--especially in terms of the interdisciplinary topics approached—demonstrates the continuing contemporary social implications of the work. The result has been a new and evolving discipline in Romanian social anthropology. In addition to describing the modern terrain of this new field, the author also mentions some of recent medical anthropology studies and the heterogeneity that lies at the core of their approaches.
Rezumat: Antropologie medicală – noi paradigme, noi limite. Articolul face o scurtă prezentare a unui nou câmp disciplinar apărut în cercetarea antropologică - antropologia medicală. După o scurtă descriere a influenţelor din istoria acestui domeniu pentru ultimele şapte decade în câmpul academic occidental, autoarea analizează originea şi traiectoria pe care această disciplină o are în România de după 1989. Articolul arată că deşi preocupările de antropologie medicală nu sunt cu totul noi, forma emergentă a disciplinei - în special în ceea ce priveşte subiectele interdisciplinare abordate - demonstrează continuitatea cu implicaţiile sociale contemporane. Rezultatul este în fapt apariţia unei noi discipline în antropologia socială românească. Autoarea mai analizează, în afara terenului modern al acestui câmp disciplinar, câteva dintre studiile recente de antropologie medicală, precum şi eterogenitatea care stă la baza acestor abordări.
Cuvinte-cheie: antropologie medicală, antropologie, biomedicină, pluralism medical, etnomedicină.
Reasons for Theism of the Person Side Notes to Roger Pouivet’s Paper: Against Theistic Personalism
Authors: Grimi Elisa
Published: June 2018

___ not requested by the Editors.
O desenvolvimento do aplicativo APPrendendo como incentivo à utilização do Tablet Educacional
Authors: Messa Menezes Júnior Jorge Alberto , Marques da Rocha Karla
Published: June 2018

O presente artigo apresenta o resultado da pesquisa desenvolvida no Programa de Mestrado Profissional em Tecnologias Educacionais em Rede (PPGTER) da Universidade Federal de Santa Maria (UFSM), que tratou do desenvolvimento de um aplicativo para dispositivos móveis, o APPrendendo, como meio de incentivo aos professores, da rede pública estadual da cidade de Alegrete-RS, a utilizarem o recurso Tablet Educacional, recebido através de um projeto governamental de fomento às tecnologias educacionais. Partindo da hipótese de que os Tablets foram pouco utilizados devido a carência de aplicativos específicos voltados aos docentes, utilizando-se de procedimentos da pesquisa-ação, buscou-se levantar as dificuldades enfrentadas na proposta, e a partir, desenvolver um aplicativo objetivando contornar o problema. O app foi desenvolvido utilizando a metodologia Engenharia Web e a abordagem Híbrida. Os requisitos foram obtidos em oficinas, que consistiram de encontros com os professores para validação e apresentação de protótipos do app. Concluído o app, foi aplicado um questionário para avaliá-lo. Analisados os dados, constatou-se que os professores consideraram o aplicativo apto para ser utilizado como recurso metodológico em suas práticas. Verificou-se também, que o processo de desenvolvimento do app, em colaboração com os docentes, contribuiu para sensibilizações, sendo mais um fator de fomento à sua utilização