bluuebunny/crossref_metadata_2025 huggingface dataset:
Engineering a Minimal 1185 Bp Cloning Vector from a Puc18 Plasmid Backbone with an Extended Multiple Cloning Site
Authors: Staal Jens , De Schamphelaire Wouter , Beyaert Rudi
Published: July 2018

Minimal plasmids play an essential role in many intermediate steps in molecular biology. They can for example be used to assemble building blocks in synthetic biology or be used as intermediate cloning plasmids that are ideal for PCR-based mutagenesis methods. A small backbone also opens up for additional unique restriction enzyme cloning sites. Here we describe the generation of a ~1kb fully functional cloning plasmid with an extended multiple cloning site (MCS). To our knowledge, this is the smallest high-copy cloning vector ever described.
PENGARUH ASPEK-ASPEK KEPEMIMPINAN PARTISIPATIF KEPALA DESA TERHADAP PEMBANGUNAN PENDIDIKAN NONFORMAL
Authors: Husain H. Walidun
Published: July 2018

The purpose of this research was to discover the influence of participative leadership aspects of village head either partially or simultaneously to the education development. The research was conducted in Gorontalo region in 2010 and the population BPD, LPM, village officials, elementary school and elementary school committee. The samples were selected by proportional random sampling technique and the main instrument employed rating scale tests in the form of close statements with alternative answers. To complete the discussion qualitatively, the research used interview technique for the Regent of Gorontalo district, the head of national education office, and other parties which considered important. After analyzing the data with path analysis, the research concluded, participative leadership aspects of village head either partially or simultaneously, give real contribution to education development.
PENGEMBANGAN MODEL BAHAN BELAJAR MANDIRI BERBASIS ANDRAGOGI UNTUK MENINGKATKAN KOMPETENSI PENDIDIK ANAK USIA DINI
Authors: Hulukati Wenny
Published: July 2018

This research aims at creating a model of self- learning materials to improve PAUD teacher’s competence in facilitating and developing learning in early childhood education. The model to be developed based on andragogy approach consists of the learning and teaching materials, learning and teaching guidelines, and assessment and evaluation guidelines. To reach the research objectives. research and development method was employed. The data was collected through observation, interview, questionnaire, and test. Data analysis used qualitative analysis capturing the analysis of preliminary research data, the result of expert validation, and try out data. Quantitative analysis was also integrated in this study for the experiment data. The result of this study shows that the self learning materials developed in this research can improve the early childhood education teacher’s competence in teaching and learning process. It is recommended therefore to use this andragogy principles based model of self learning package for early childhood education teachers.
PENGEMBANGAN MODEL KOMUNITAS TERAPEUTIK (THERAPEUTIC COMMUNITY) BERBASIS IMAN DAN TAKWA UNTUK MEMBINA AKHLAK MULIA
Authors: Endang Busri
Published: July 2018

This study was based on the researcher’s concern about worsening drugs abuse in the community. Drugs Rehabilitation Center Wisma Sirih Pontianak provides assistance for parents of drugs abuse victims by applying “Therapeutic Community” (TC) method. The method was considered as containing less religious faith values for character building, so it has further been developed into “Religious Faith-Based Therapeutic Community for Character Building of Drugs Addicts”. The study aims at describing the application of TC method, assessing the strengths and weaknesses of TC method, formulating a theoretical concept of religious faith-based TC model for good character building, and evaluating the effectiveness of TC model in fostering good character. The study adopts R&D method and qualitative approach. Data were collected with interview, observation, and literature review. Findings can be described as follows TC model could develop good behaviors of drugs addicts, the characteristics of the TC model include belief in the essence of Thoyyibah meaning, focused prayers, knowledge and reflection, ikramul muslimin, tash hihun niyyah, dakwah and tabligh, making the residents quit the drugs, recovered faster, get well, and invite their friends to stay away from the drugs.
IMPLEMENTASI MODEL PEMBELAJARAN KEMANDIRIAN BERBASIS SATYA DAN DARMA PRAMUKA DALAM MEMBENTUK GENERASI MUDA MANDIRI PADA KEGIATAN ALAM TERBUKA
Authors: Muchtar Utang Mochamad , Trisnamansyah Sutaryat
Published: July 2018

The aims of out of school education is to make independent human, especially the young generation. Now, many problems which found in young generations, like juvenile delinquency, drugs, rape, and the otehers problem which impacts of the weakness nation’s potential, so it must be done. Scouting method is a solution which expacted to give education value to make indpendent young generation. This sarticle specially discuss abaout implementation indepence learning model based Satya and Darma’s Scout to make independent young generation in open natural activity. This article conclude that effectiveness of independence learning model in open natural activity if implemented according to scout’s fundamental principles and method by a deeper understanding the meaning of the life in universe.
POLA PENGENDALIAN SOSIAL MASYARAKAT MULTIKULTURAL
Authors: Rivaie Wanto
Published: July 2018

The result of this research indicated that: (1) the couses of Dayak, Melayu and Madura ethnics in Sebangki Villages, Landak District, West Kalimantan avoided from conlict are because of the competition of jobsorder are very little. The limitation of physical infrastructures building like: streets, electricity, and telephone or celularphone that can be used for social movement, relatively long distance between village to village and the most of existing government and education institution, as well as institutions of religious, politics, and the family function still are efectif to maintain threir daily social life; (2) social interactional models between Dayak,Melayu and Madura can be conducted through married system, economic activities, institutions: of adat Dayak Kanayatn, social/ education, religious, and politics; (3) the construction ofsocial capital between those etnics is very strong ; (4) the social engineering which conducted by government institution and the existing institutions of: adat, social/ education, religious, politics, and the family function in Sebangki villages are very high. The methods of social control within multicultural ethnics in Sebangki use persuasive and coersief techniques. This techniques may be appropriate because they can give positive responses for the whole people as well as motivate people to have more interactions and consequently tighten the social capital and social integration among ethnics in Sebangki.
PENGEMBANGAN MODEL PELATIHAN PERMAINAN TRADISIONAL EDUKATIF BERBASIS POTENSI LOKAL DALAM MENINGKATKAN PENGETAHUAN DAN KETERAMPILAN ORANG TUA ANAK USIA DINI
Authors: Badu Ruslin W.
Published: July 2018

The aim of this research is to deliver a training model that can increase the knowledge and skill of the parents of the early children to perform education in the family environment. To reach the goal it is developed the educative traditional game based on the local potency. After attending the training, it is expected that the skill and knowledge of the parents in applying the traditional game can be increased.The method of this study is research and development model. The subject of the research was the parents of the early-age children who were staying to take care of their children during their study at the PAUD Kota Gorontalo, 50 of which were used in the previous study and the other 40 were used in the model implementation, and they were divided into two groups, the experiment and control groups (20 for each).The purposive sampling, the test, interview, questionnaire, and documentation study were applied in this research. It applied the quasy experiment (Non Equivalent Group Pretest-Posttest Design). The research result indicates local potency based educative traditional game model has effectively increased the knowledge and skills of the early age children’s parents at PAUD Kota Gorontalo.
MODEL KOMUNITAS PRAKTEK BERBASIS MODAL SOSIAL UNTUK PENINGKATAN MUTU PENDIDIKAN KEWIRAUSAHAAN MASYARAKAT
Authors: Tohani Entoh , Sujarwo Sujarwo
Published: July 2018

This study aims to develop model of community of practice based on social capital for improving quality of the community entrepreneurship education and also to contribute the decision making process for community development, theory and practice development. The study used research and development approach which consisted of four steps: need assessment, designing of the conceptual model, and try out in limited field. Taking place in Yogyakarta Special Province, the study selected the community entrepreneurship education in Gunung Kidul Regency and the enterprise learning groups in Bantul Regency. In this study, data collection used interview, observation, documentation and questionare, and analysis of data used qualitative and quantitative technique. The result shows that it`s could be developed the model of community of practice based on social capital for developing the entrepreneurship education quality and also guidance for managing the model which was be validated. The other finding are actions of the model development could be able to encourage consciousness of the target groups to build, manage, and keep the community practice in their enterprise, motivated the target group to participate actively in their enterprise and find out new understanding and knowledge by held learning activities. So that, it is needs to implementation the community of practice based social capital model in developing community entrepreneurship education in future for continuing and controlling the quality.
KEMAMPUAN MENYELESAIKAN SOAL CERITA MATEMATIKA
Authors: Kaprinaputri Astra Puspita
Published: July 2018

This study aims to describe the ability of Kumon’s students, 7-8 years old, in solving mathematics word problems. This study done in December 2012 used cumulative approach with survey method. The respondents were the students of Kuman Course in North Jakarta. The data collected by distributing the questions to the respondents were analyzed applying simple statistic technique. Findings show that 86%of the respondents belong to high category while 14% belong to medium category. and no students belongs to low category. The implication of this study is Kumon students have the ability to solve mathematics word problem, but they still have to do more exercises in solving mathematics word problems continually. Besides, the Kumon Course should use media in the teaching of mathematics word problems.
KEMAMPUAN SOSIALISASI DAN GERAK MANIPULATIF BERBASIS KELOMPOK PADA ANAK USIA 4-5 TAHU
Authors: Sumantri Mohamad Syarif , Endrawati Tjia
Published: July 2018

The purpose of this study is to answer the problem of how to improve the social skills of children aged 4-5 years through group -based manipulative motion activity. The research was carried out in the children group of 4-5 years old at The Kindergarten of IPEKA Sunter, North Jakarta as from March through May 2011. The research method used an action research approach through cycles: initial assessment planning, action, observation and reflection, the research carried out in 2 cycles, data collected by the instrument type observation, interviews and documents,with mixmethod data analysis, and data validity by triangulation methods and sources. The results of data analysis show an overall group -based manipulative movement has increased the social skills of children aged 4-5 years was 76.77 % , makes no difference that drives the improvement of learning outcomes is through manipulative motion activity -based group has given children the opportunity to interact intensively, fun atmosphere, providing the freedom of choice of activity , active child, role sharing, collaboration, and empathy. The implication of this study is if the activity group -based manipulative movement properly made and programmed it will have a positive impact on the development potential of the socialization of children.
PENGEMBANGAN KURIKULUM PROGRAM PAKET B
Authors: Hadiyanti Puji
Published: July 2018

The Community Learning Center (CLC) as an educational institution to implement Package A Program is assigned to produce the graduates having equivalent competence as Junior High School does. Besides, the learners are also expected to be able to meet their needs and solve their problems. CLC has to develop the existing curriculum to complete its tasks as expected. This research is intended to know the curriculum at CLC of Tunas Bangsa, Probolinggo District, East Java, and how it develops and implements the curriculum. The research conducted as from April through July 2010, reviewed the existing curriculum using qualitative method and then developed the curriculum on the basis of local needs and potentials. The result of the study is an integrated curriculum to be used by tutors and will encourage them to improve theircompetence.
THE INFLUENCE OF MARKETING MIX ON DECISIONS TO BE A ISLAMIC BANKING CUSTOMER IN CIANJUR REGENCY
Authors: Husaeni Uus Ahmad
Published: July 2018

Keputusan masyarakat untuk memilih perbankan
syariah di Kabupaten Cianjur sangat rendah. Saat
ini, nasabah perbankan syariah di Kabupaten
Cianjur hanya sekitar 5-8 % dari total penduduk
yang berjumlah 2.335 juta jiwa. Padahal, 98 %
penduduk di Kabupaten Cianjur beragama Islam
yang juga dikenal sebagai kota santri. Oleh karena
itu, perlu dilakukan pengujian apakah marketing
mix yang meliputi produk, harga, tempat, dan
promosi mampu mempengaruhi keputusan
menjadi nasabah perbankan syariah. Penelitian ini
bertujuan untuk menguji pengaruh produk, harga,
tempat, dan promosi terhadap keputusan menjadi
nasabah perbankan syariah. Alat analisis yang
digunakan dalam penelitian ini adalah analisis
regresi linear berganda. Hasil penelitian, secara
simultan menunjukkan bahwa produk, harga,
tempat, dan promosi berpengaruh signifikan
terhadap keputusan menjadi nasabah perbankan
syariah, sedangkan sisanya dijelaskan oleh faktor
lain yang tidak diikutsertakan dalam penelitian
ini.
Formalization and elaboration of a company’s business strategy
Authors: V. Balashova Karina , M. Batkovskiy Aleksandr , A. Kalachikhin Pavel , G. Semenova Elena , F. Telnov Yury , V. Fomina Alena
Published: July 2018

The article deals with issues of formalization and elaboration of business strategies. The authors have formulated a hypothesis that there is no universal strategy ensuring maxi¬mum benefit to an enterprise. The choice of a company’s strategy is considered from the point of view of a game-theoretical interpretation as a competition component. The process of engineering a company’s business strategy is presented in the form of a technological network. The study shows the possibility of automating the selection of a strategy by decision-making support systems. The article outlines the problem of classifying enterprise strategies by general features. The structure of a company’s strategy is formalized as a relationship of a set of strategic objectives in the S.M.A.R.T. technique and a set of means to achieve the goals limited by a company’s capabilities. The authors examine the indicator structure for achieving strategic goals. A definition is given to the type and form of a strategy based on the pattern concept. The article defines a methodology for assessing the probability of achieving the strategic goal. A new concept of a fluid strategy has been introduced along with several other variations of business strategies that might be encountered.
İşiten ve İşitme Yetersizliği Olan Öğrencilerin Özetleme Becerilerinin Karşılaştırmalı Olarak İncelenmesi
Authors: Sümer Halime Miray , Turna Cebrail
Published: July 2018

Bu çalışmada sekizinci sınıfta öğrenim gören işiten ve işitme
yetersizliği olan öğrencilerin öyküleyici metinleri özetleme becerileri ve
oluşturulan metinlerin bağdaşıklık düzeyleri açısından değerlendirilmesi
amaçlanmıştır. Araştırmanın çalışma grubunu Ankara İli’nde sekizinci sınıfta
öğrenim gören 15 işitme yetersizliği olan öğrenci, 15 işiten öğrenci
oluşturmaktadır. Yapılan analiz sonucunda özetlemenin içerik, biçim, dil ve
anlatım, metin yapısı alt boyutlarında ve özetleme toplam puanda işitme
yetersizliği olan öğrenciler ve işiten öğrenciler arasında anlamlı bir fark
bulunmuştur. İşiten öğrenciler özetleme becerisinin alt boyutlarına ve özetleme
becerisi toplam puanlarına göre işitme yetersizliği olan öğrencilerden daha
yüksek olduğu görülmüştür. Bağdaşıklık düzeyinde ise gönderim, eksiltili
anlatım, bağlama öğeleri alt boyutlarında ve bağdaşıklık araçlarını toplam
kullanım sıklıklarında işitme yetersizliği olan öğrenciler ve işiten öğrenciler
arasında anlamlı bir fark bulunmuştur. Bağdaşıklık düzeyinin değiştirim alt boyutunda
işiten ve işitme yetersizliği olan öğrenciler arasında anlamlı bir fark
bulunmamıştır.
The Use of Think, Pair, Share Learning Method to Improve Vocabulary Mastery of the Second Class Students of Muhammadiyah Vocational High School, Salatiga in Academic Year 2011/2012
Authors: Hidayati Ida Ubaidah
Published: July 2018

The Aim of this research is to what extent does "Think, Pair, Share" use to improve the students' interest in the teaching-learning process for second class students of SMK Muhammadiyah Salatiga. The methodology of the study is classroom action research, where the writer as a teacher in the teaching-learning process, and writer had a partner as observer in learning activities. The objectives of the study are to what extent does "Think, Pair, Share" use to improve the vocabulary mastery, and to what extent does "Think, Pair, Share" use to improve the vocabulary mastery for the second year students of SMK Muhammadiyah Salatiga. The writer applied test, namely pre-test, and post-test. She implemented three cycles. Each consists of planning, implementation of the action, observation, and reflection. The finding shows that Think, Pair, Share learning method can improve vocabulary in teaching-learning process. It can be seen by the result of pretest and posttest in cycle I is 5.49, cycle II is 6.32, and cycle III is 8.03. From the result is greater than t-table with n=33 is 0.42. It means that the use of TPS can improve the student's vocabulary mastery.
Enhancing Students’ Ability in Writing Descriptive Text through Graphic Organizers
Authors: Maslichah Maslichah , Tarwiyah Siti
Published: July 2018

Graphic organizers are visual displays of crucial content information designed to benefit learners who have difficulty organizing information and it could help the students to build and generate ideas. The study was aimed at finding the answers to the following research questions: (1) How is the implementation of graphic organizers to enhance students' ability in writing the descriptive text? (2) How is the enhancement of students' ability in writing descriptive text through graphic organizers? This study was a classroom action research. The data were obtained through documentation, observation, and test. It was conducted in three cycles with the 24 eighth grade students of MTs Nurul Islam Juwangi in the academic year of 2016/2017. The result of this research showed that students’ ability was improved in each cycle after they were taught using graphic organizers. They were better in their descriptive text writing concerning content, organization, vocabulary, language use, and mechanic.
Code Alternations in Bilingual Representation and a Communication Strategy in Tuan Guru Bajang’s Islamic Speech
Authors: Thohir Lalu
Published: July 2018

The present writing is a study of code alternation in TGB’s Islamic speech. TGB which stands for “Tuan Guru Bajang” is a well-known name for Dr. M. Zainul Majdi, M.A, a famous Islamic preacher in Lombok and at present, he is the governor of West Nusa Tenggara province. The data of this study were obtained from one of TGB’s Islamic speech recordings. They were first classified into inter-sentential switching, tag-switching, and intra-sentential switching and then they were analyzed to know their functions which involve a topic switch, effective and repetitive functions. The findings show that intra-sentential switching which reflects repetitive function appeared most frequently in TGB’s Islamic speech. The code alternation in TGB’s Islamic speech represents bilingualism and has proved to be an effective strategy in communication.
Hybrid Learning of Daviq.com in the Subject of Teaching Listening and Speaking
Authors: Rizal Daviq
Published: July 2018

The term hybrid learning was used to describe online learning combined with face-to-face interaction in the classroom. There are two research questions the first question is how the development of hybrid learning in http://daviqr.com/ is. The second one is how the moodle-based hybrid learning of http://daviqr.com/ as a teaching model in the subject of teaching listening and speaking to the students of English Department of IAIN Walisongo Semarang in the academic year of 2013/2014 is. This research is a research and development, which has the population of all fourth semester English department students of the Faculty of Teachers' Training and Education, IAIN Walisongo Semarang that takes the subject of Teaching Listening and Speaking in the academic year 2013/2014, which consists of three classes. The number of population is 120 students. Regarding the research findings that there are some main reasons why most students agree that the hybrid learning course is an exciting course and why they prefer the hybrid online course or the combination between online and traditional classroom. First, the course outline and objectives were made clear. Second, they learned a lot from this hybrid course. Third, the reading materials were clear and informative. Fourth, the level of this hybrid course is just right. Fifth, the total study load of this hybrid course is in proportion to the number of semester credits is just right. Sixth, the amount of their interaction with other students is a little better. Seventh, the quality of their interaction with other students is a little better. Eighth, the amount of their interaction with the instructor is a little better. Ninth, the quality of their interaction with the instructor is a little better and about the same. Tenth, compared to a face-to-face (traditional) class of equal credits, the workload of this online course is somewhat more. There are some recommendations I should give. First, UIN Walisongo Semarang must design e-learning for lecturers as many students like hybrid courses. Second, the faculty must improve the quality of Wi-Fi hotspots.
Heme Oxygenase and the Skin in Health and Disease
Authors: Szabo Imre Lorinc , Kenyeres Anna , Szegedi Andrea , Szollosi Attila Gabor
Published: July 2018

The skin is often introduced as the largest organ of the human body which – being uniquely exposed to
external stress – faces several types of challenges, from physical, chemical, biological, and immunological origin.
Therefore, the skin is also a site where inflammation, oxidative stress and cellular damage occurs regularly. Heme
oxygenase (HO), primarily functioning in the catabolism of heme, is a very important cytoprotective enzyme that
has antioxidant, anti-inflammatory and anti-apoptotic properties. Given the need for an enzyme with such a combination
of attributes in the skin, it is not surprising that HO is involved in physiological processes as well as
pathological conditions of the skin. In the recent decade, a huge effort was undertaken to identify treatments that
modify HO-activity for the treatment of inflammatory or malignant skin diseases. In this review, we highlight the
role of HO in the skin in physiological conditions as well as in relevant dermatological diseases such as atopic
dermatitis, psoriasis and melanoma.
Parkinson’s Disease: Alpha Synuclein, Heme Oxygenase and Biotherapeutic Countermeasures
Authors: Haines David D. , Trushin Maxim V. , Rose Stephen , Bernard Iloki Assanga Simon , Mahmoud Fadia F.
Published: July 2018

Neurodegenerative disorders have been and remain persistent sources of enormous suffering throughout
human history. The tragedy of their impact on human relationships, physical vitality, and fundamental dignity
cannot be understated. Parkinson’s disease (PD), one of the most common of these terrible illnesses, has a global
incidence of approximately two-to-four percent of the human population, along with devastating social and economic
impact. The present review analyzes aspects of PD pathophysiology that offer particularly attractive strategies
for the development of improved prevention and therapy. The occurrence, symptoms, pathogenesis, and
etiology of PD are considered, with focus on how the Alpha synuclein protein, which normally regulates neurotransmitter
release, is aggregated by oxidative stressors into toxic inclusions, prominently including Lewy bodies
and insoluble fibrils that disrupt the organization of brain areas responsible for motor control. The contribution to
a progressively prooxidant tissue environment resulting from interaction between advanced glycation end
products (AGEs) and their cognate receptors (RAGEs) is examined here as a significant driver of PD. This review
also explores strategies currently being developed by a U.S.-Russian team that may reduce the risk and severity of
PD by use of recombinant atoxic derivatives (ad) of botulinum neurotoxins (BoNT/A ad), that traffic inducers of
the cytoprotective enzyme heme oxygenase to selected midbrain neurons, at which Alpha synuclein aggregation
occurs. Considered together, the topic material presented here provides both researchers and clinicians with a
short but concise overview of the current understanding of PD pathology and approaches to biotherapeutic
(precision) countermeasures to its onset and progression.
Chemistry and Pharmacology of Luliconazole (Imidazole Derivative): A Novel Bioactive Compound to Treat Fungal Infection-A Mini Review
Authors: Mishra Arun K. , Kumar Arvind , Singh Harpreet , Verma Shweta , Sahu Jagdish K. , Mishra Amrita
Published: July 2018

Background:

Currently, ringworm treatment drugs include two major categories: first, propylene
amine drugs, such as terbinafine, butenafine and naftifine, which exert their bactericidal effects
through inhibiting squalene cyclase, causing the lack of ergosterol and accumulation of squalene. The
second category of imidazole drugs includes miconazole, econazole, clotrimazole, ketoconazole and
bifonazole.

Mechanism:

These synthetic antifungal agents exhibits their action by inhibiting the lanosterol 14α-
demethylation activity of fungal cell, leading to the prevention of the ergosterol synthesis of cell membrane,
changing the cell membrane permeability, and resulting in the loss of important intracellular fungal
material and causing fungal death.

Applications:

At present, Imidazole antifungal agents are commonly used drugs in clinical treatment of
ringworm with extensive clinical applications.

Conclusion:

The present review covers the chemistry and detailed pharmacology aspects of luliconazole.
Determination of Verapamil in Exhaled Breath Condensate by Using Microextraction and Liquid Chromatography
Authors: Pourkarim Fariba , Shayanfar Ali , Khoubnasabjafari Maryam , Akbarzadeh Fariborz , Sajedi-Amin Sanaz , Jouyban-Gharamaleki Vahid , Jouyban Abolghasem
Published: July 2018

Background:

Developing a simple analysis method for quantification of drug concentration is one of the essential issues in pharmacokinetic and therapeutic drug monitoring studies.

Objective:

A fast and reliable dispersive liquid-liquid microextraction procedure was employed for preconcentration of verapamil in exhaled breath condensate (EBC) samples and this was followed by the determination with high-performance liquid chromatography-ultraviolet detection.

Methods:

A reverse-phase high-performance liquid chromatography (RP-HPLC) combined with a dispersive liquid-liquid microextraction method (DLLME) was applied for quantification of verapamil in the EBC samples. The developed method was validated according to FDA guidelines.

Results:

Under the optimum conditions, the method provided a linear range between 0.07 and 0.8 µg.mL-1 with a coefficient of determination of 0.998. The intra- and inter-day relative standard deviation and relative error values of the method were below 15%, which indicated good precision and accuracy. The proposed method was successfully applied for the analysis of verapamil in two real samples with concentrations of 0.07 and 0.09 µg.mL-1.

Conclusion:

The established HPLC-UV-DLLME method could be applied for the analysis of verapamil in human EBC samples.
Dual Antibacterial and Anticancer Activity of 4-Benzoyl-1-dichlorobenzoylthiosemicarbazide Derivatives
Authors: Kapron Barbara , Czarnomysy Robert , Paneth Agata , Wujec Monika , Bielawski Krzysztof , Bielawska Anna , Swiatek Lukasz , Rajtar Barbara , Polz-Dacewicz Malgorzata , Plech Tomasz
Published: July 2018

Objective/Method: A group of 4-benzoyl-1-dichlorobenzoylthiosemicarbazides endowed
with antibacterial activity was evaluated for its cytotoxic properties against breast cancer cells (MCF-7,
MDA-MB-231) and head and neck squamous cell carcinomas (FaDu, SCC-25). Cytotoxicity of the investigated
compounds was measured using MTT and [3H]-thymidine incorporation bioassays.

Result:

1-(2,3-Dichlorobenzoyl)-4-(2-methylbenzoyl)thiosemicarbazide (TA-4), 1-(2,4-dichlorobenzoyl)-
4-(2-methylbenzoyl)thiosemicarbazide (TA-18), and 1-(2,4-dichlorobenzoyl)-4-(4-nitrolbenzoyl)-
thiosemicarbazide (TA-20) were found to possess anticancer activity equipotent or even stronger than
that of reference drug – etoposide. In order to clarify the molecular mode of action of the mentioned
compounds, the relaxation assay kit for human DNA topoisomerase II was used. It turned out that reduction
of viability of cancer cells was a result of inhibition of human DNA topoII. Molecular docking
studies proved that 4-benzoyl-1-dichlorobenzoylthiosemicarbazides strongly interact with DNAdependent
subunit of that enzyme.
Tweeting the Author: Tao Lin’s Performance of Authorial Identity on Twitter
Authors: Greene Justin Russell
Published: July 2018

This article takes a closer look at how the American author Tao Lin uses Twitter to perform his authorial identity. Twitter serves as a primary platform for Lin to shape and reshape the public images of him as an author. Lin’s Twitter presence operates as 140-character bursts of authorial self-presentation. The tweets he chooses to post combined with his views on Twitter as a presentational platform show that Lin is conscious of his identity performance, especially online. With this knowledge, he uses the language of Twitter to enact his authorial identity and influence the representations that circulate in the literary world, but he fell short because of the dominant role print media play in images of authorship. To counteract this and gain cultural legitimacy for his online identity in the literary world, Lin resorts to remediating his Twitter profiles into a fetishized print book. Lin’s coquettish relationship with Twitter shows his audience that the platform is more than a place to generate attention for oneself; it is a site for the continual reshaping of identity on a mass scale.
Modal sosial dan media sosial pada masyarakat cyber di Desa Melung, Kabupaten Banyumas
Authors: Malik Imam , Dwiningrum Siti Irene Astuti
Published: July 2018

Penelitian ini bertujuan untuk mendeskripsikan: (1) penggunaan media sosial, (2) memetakan modal sosial, dan (3) menganalisis peran modal sosial dalam membentuk pola penggunaan media sosial yang ada pada masyarakat cyber di desa Melung. Penelitian ini menggunakan pendekatan kualitatif dengan kajian fenomenologi. Unit analisisnya adalah masyarakat desa Melung. Data primer diperoleh dari hasil wawancara terhadap berbagai kategori informan di desa Melung. Analisis data dilakukan dengan mengumpulkan data, mereduksi data, dan verifikasi yang dilakukan secara bertahap. Hasil penelitian menunjukan bahwa media sosial di desa Melung digunakan sebagai media promosi bagi masyarakat untuk mempromosikan desa mereka sebagai desa wisata. Keberadaan media sosial dan pemanfaatanya sebagai media promosi didukung oleh kepercayaan masyarakat terhadap kepala desa. Kpercayaan masyarakat terhadap kepala desa berperan sebagai modal sosial yang ada di desa Melung. Keberadaan modal sosial yang dimiliki oleh masyarakat berperan sebagai pembentuk masyarakat cyber dan juga faktor utama terealisasinya pembangunan jaringan interenet di desa Melung.Kata kunci: media sosial, masyarakat cyber, modal sosial SOCIAL CAPITAL AND SOCIAL MEDIA IN CYBER SOCIETY IN THE MELUNG VILLAGE, REGENCY OF BANYUMASAbstractThis study aims to describe: (1) the use of social media, (2) mapping social capital, and (3) analyzing the role of social capital in shaping the patterns of using social media that exist in the cyber community in Melung village. This research used qualitative approach with phenomenology study. The unit of analysis is Melung village society. Primary data were obtained from interview on various categories of informants in Melung village. Data analysis was done by collecting data, reducing data, and verification which done in stages. The results showed that social media in Melung village was used as a media campaign for the community to promote their village as a tourist village. The existence of social media and their use was supported by the public's trust in the village head. The public's trust in the village head served as a social capital in the village Melung. The role of social capital that exists was as reinforcement in shaping the cyber community and the main factor of the realization, construction of the interenet network in the Melung  village.Keywords: social media, cyber society, social capital
Pendidikan karakter dalam Serat Tripama karya Mangkunegara IV
Authors: Wardhani Novia Wahyu , Muhadjir Noeng
Published: July 2018

Tujuan penelitian ini adalah untuk menggali kembali nilai-nilai kearifan lokal masa lalu seperti dalam Serat Tripama Karya Mangkunegara IV sehingga dapat dibedakan mana yang harus diteladani dan mana yang tidak tetapi dapat dijadikan materi analisis nilai dalam pembelajaran. Metode yang digunakan adalah metode kualitatif dengan pendekatan interpretasi, hermeneutik, dan verstehen. Teknik analisis yang digunakan adalah analisis data model interaktif yang terdiri dari pengumpulan data, reduksi data, penyajian data, dan verifikasi. Hasil penelitian ini adalah tidak semua nilai dapat dijadikan sumber keteladanan bagi pembentukan karakter peserta didik.  Nilai yang dapat diteladani adalah nilai niat yang baik, pengabdian yang tulus disertai dengan usaha, dan kerelaan berkorban pada kebenaran.Kata kunci: pendidikan karakter, serat tripama, Mangkunegara IV CHARACTER EDUCATION IN SERAT TRIPAMA BY MANGKUNEGARA IVAbstractThe purpose of this research is to dig again values local knowledge the past as work in the Serat Tripama Mangkunegara iv so as to be distinguishable which one to role models all and which ones have not but can be used as matter analysis value in learning. Methods used was a qualitative methodology with the approach interpretation, hermeneutic, and verstehen. Technique the analysis used is interactive data analysis model consisting of data collection, reduction data, presentation of data, and verification. The result of this research is not all value can be used as a source of exemplary for the establishment of character school tuition. Value that can be role models all is the value of good reasons, devotion sincere accompanied by business, and mutual consent sacrifice to the truth.Keywords: character education, serat tripama, Mangkunegara IV
Penanaman nilai-nilai religius di madrasah aliyah Nahdlatul Wathan Pancor Lombok Timur Nusa Tenggara Barat
Authors: Manan Abd. Latif , Kuntoro Sodiq A. , Sudrajat Ajat
Published: July 2018

Penelitian ini dimaksudkan untuk; (1) mengetahui dan mengkaji upaya penanaman nilai-nilai religius di Madrasah Aliyah Nahdlatul Wathan Pancor Lombok Timur; (2) menganalisis faktor-faktor penghambat pengembangan nilai-nilai religius di Madrasah Aliyah Nahdlatul Wathan Pancor Lombok Timur. Metode yang digunakan dalam penelitian ini adalah metode studi kasus dengan pendekatan kualitatif. Penelitian dilakukan di Madrasah Aliyah Nahdlatul Wathan Kelurahan Pancor Kabupaten Lombok Timur Provinsi Nusa Tenggara Barat. Data diperoleh melalui observasi, wawancara, dan dokumentasi. Teknik analisis data menggunakan reduksi data, display data, penarikan serta pengujian kesimpulan. Hasil penelitian menunjukkan bahwa: (1) Penanaman  nilai-nilai religius di Madrasah Aliyah Nahdlatul Wathan Pancor ditempuh melalui beberapa upaya, yakni: (a) melalui kegiatan belajar mengajar di dalam kelas maupun di luar kelas melalui kegiatan keagamaan; (b) menggunakan berbagai strategi; serta (c) menjalin kerja sama sekolah dengan orang tua siswa; (2) faktor-faktor yang mempengaruhi penanaman nilai-nilai religius berasal dari faktor guru, siswa, dan orang tua siswa.Kata kunci: nilai, religius, perilaku keagamaan siswa  INCULCATING RELIGIOUS VALUES IN MADRASAH ALIYAH NAHDLATUL WATHAN PANCOR EAST LOMBOKAbstractThis research is intended for: (1) knowing and reviewing the effort of inculcating religious values in Madrasah Aliyah Nahdlatul Wathan Pancor East Lombok; (2) analyzing the factors that hamper the Inculcating of religious values in Madrasah Aliyah Nahdlatul Wathan Pancor East Lombok. The method used in this research is case study method with qualitative approach. The research was conducted at Madrasah Aliyah Nahdlatul Wathan, Pancor Sub-District, East Lombok Regency, West Nusa Tenggara Province. Data were obtained through observation, interviews, and documentation. Data analysis techniques using data reduction, data display, and drawing and verifying conclusions. The results showed that: (1) inculcating of religious values in Madrasah Aliyah Nahdlatul Wathan Pancor taken through several efforts, namely: (a) through teaching and learning activities in the classroom or outside the classroom through religious activities; (b) using various strategies, and (c) establish school cooperation with parents of students; (2) factors influencing the inculcating of religious values are derived from teachers, students, and parents.Keywords: values, religious, student’s religious behavior
A Patient-Facing Diabetes Dashboard Embedded in a Patient Web Portal: Design Sprint and Usability Testing
Authors: Martinez William , Threatt Anthony L , Rosenbloom S Trent , Wallston Kenneth A , Hickson Gerald B , Elasy Tom A
Published: July 2018

Background

Health apps and Web-based interventions designed for patients with diabetes offer novel and scalable approaches to engage patients and improve outcomes. However, careful attention to the design and usability of these apps and Web-based interventions is essential to reduce the barriers to engagement and maximize use.

Objective

The aim of this study was to apply design sprint methodology paired with mixed-methods, task-based usability testing to design and evaluate an innovative, patient-facing diabetes dashboard embedded in an existing patient portal and integrated into an electronic health record.

Methods

We applied a 5-day design sprint methodology developed by Google Ventures (Alphabet Inc, Mountain View, CA) to create our initial dashboard prototype. We identified recommended strategies from the literature for using patient-facing technologies to enhance patient activation and designed a dashboard functionality to match each strategy. We then conducted a mixed-methods, task-based usability assessment of dashboard prototypes with individual patients. Measures included validated metrics of task performance on 5 common and standardized tasks, semistructured interviews, and a validated usability satisfaction questionnaire. After each round of usability testing, we revised the dashboard prototype in response to usability findings before the next round of testing until the majority of participants successfully completed tasks, expressed high satisfaction, and identified no new usability concerns (ie, stop criterion was met).

Results

The sample (N=14) comprised 5 patients in round 1, 3 patients in round 2, and 6 patients in round 3, at which point we reached our stop criterion. The participants’ mean age was 63 years (range 45-78 years), 57% (8/14) were female, and 50% (7/14) were white. Our design sprint yielded an initial patient-facing diabetes dashboard prototype that displayed and summarized 5 measures of patients’ diabetes health status (eg, hemoglobin A1c). The dashboard used graphics to visualize and summarize health data and reinforce understanding, incorporated motivational strategies (eg, social comparisons and gamification), and provided educational resources and secure-messaging capability. More than 80% of participants were able to successfully complete all 5 tasks using the final prototype. Interviews revealed usability concerns with design, the efficiency of use, and content and terminology, which led to improvements. Overall satisfaction (0=worst and 7=best) improved from the initial to the final prototype (mean 5.8, SD 0.4 vs mean 6.7, SD 0.5).

Conclusions

Our results demonstrate the utility of the design sprint methodology paired with mixed-methods, task-based usability testing to efficiently and effectively design a patient-facing, Web-based diabetes dashboard that is satisfying for patients to use.
Evaluating a Web-Based Social Anxiety Intervention Among Community Users: Analysis of Real-World Data (Preprint)
Authors: McCall Hugh Cameron , Helgadottir Fjola Dogg , Menzies Ross G , Hadjistavropoulos Heather D , Chen Frances S
Published: July 2018

BACKGROUND

Social anxiety is both harmful and prevalent. It also currently remains among the most undertreated major mental disorders, due, in part, to socially anxious individuals’ concerns about the stigma and expense of seeking help. The privacy and affordability of computer-aided psychotherapy interventions may render them particularly helpful in addressing these concerns, and they are also highly scalable, but most tend to be only somewhat effective without therapist support. However, a recent evaluation of a new self-guided, 7-module internet-delivered cognitive behavioral therapy intervention called Overcome Social Anxiety found that it was highly effective.

OBJECTIVE

The initial evaluation of Overcome Social Anxiety revealed that it led to significant reductions in symptom severity among university undergraduates. The aim of this study was to extend the results of the initial study and investigate their generalizability by directly evaluating the intervention’s effectiveness among a general community sample.

METHODS

While signing up for Overcome Social Anxiety, users consented to the usage of their anonymized outcome data for research purposes. Before and after completing the intervention, users completed the Fear of Negative Evaluation Scale (FNE), which we employed as the primary outcome measure. Secondary outcome measures included the Depression Anxiety Stress Scales (DASS) and 2 bespoke questionnaires measuring socially anxious thoughts (Thoughts Questionnaire) and avoidance behaviors (Avoidance Questionnaire).

RESULTS

Participants who completed the intervention (102/369, 27.7%) experienced significant reductions in the severity of their symptoms on all measures employed, including FNE (P<.001; Cohen d=1.76), the depression subscale of DASS (P<.001; Cohen d=0.70), the anxiety subscale of DASS (P<.001; Cohen d=0.74), the stress subscale of DASS (P<.001; Cohen d=0.80), the Thoughts Questionnaire (P<.001; Cohen d=1.46), and the Avoidance Questionnaire (P<.001; Cohen d=1.42).

CONCLUSIONS

Our results provide further evidence that Overcome Social Anxiety reduces the severity of social anxiety symptoms among those who complete it and suggest that its effectiveness extends to the general community. The completion rate is the highest documented for a fully automated intervention for anxiety, depression, or low mood in a real community sample. In addition, our results indicate that Overcome Social Anxiety reduces the severity of symptoms of depression, physiological symptoms of anxiety, and stress in addition to symptoms of social anxiety.
Feasibility Randomized Controlled Trial of ImpulsePal: Smartphone App–Based Weight Management Intervention to Reduce Impulsive Eating in Overweight Adults (Preprint)
Authors: van Beurden Samantha B , Smith Jane R , Lawrence Natalia S , Abraham Charles , Greaves Colin J
Published: July 2018

BACKGROUND

ImpulsePal is a theory-driven (dual-process), evidence-informed, and person-centered smartphone app intervention designed to help people manage impulsive processes that prompt unhealthy eating to facilitate dietary change and weight loss.

OBJECTIVE

The aims of this study were to (1) assess the feasibility of trial procedures for evaluation of the ImpulsePal intervention, (2) estimate standard deviations of outcomes, and (3) assess usability of, and satisfaction with, ImpulsePal.

METHODS

We conducted an individually randomized parallel two-arm nonblinded feasibility trial. The eligibility criteria included being aged ≥16 years, having a body mass index of ≥25 kg/m2, and having access to an Android-based device. Weight was measured (as the proposed primary outcome for a full-scale trial) at baseline, 1 month, and 3 months of follow-up. Participants were randomized in a 2:1 allocation ratio to the ImpulsePal intervention or a waiting list control group. A nested action-research study allowed for data-driven refinement of the intervention across 2 cycles of feedback.

RESULTS

We screened 179 participants for eligibility, and 58 were randomized to the intervention group and 30 to the control group. Data were available for 74 (84%, 74/88) participants at 1 month and 67 (76%, 67/88) participants at 3 months. The intervention group (n=43) lost 1.03 kg (95% CI 0.33 to 1.74) more than controls (n=26) at 1 month and 1.01 kg (95% CI −0.45 to 2.47) more than controls (n=43 and n=24, respectively) at 3 months. Feedback suggested changes to intervention design were required to (1) improve receipt and understanding of instructions and (2) facilitate further engagement with the app and its strategies.

CONCLUSIONS

The evaluation methods and delivery of the ImpulsePal app intervention are feasible, and the trial procedures, measures, and intervention are acceptable and satisfactory to the participants.

CLINICALTRIAL

International Standard Randomized Controlled Trial Number (ISRCTN): 14886370; http://www.isrctn.com/ISRCTN14886370 (Archived by WebCite at http://www.webcitation.org/76WcEpZ51)