bluuebunny/crossref_metadata_2025 huggingface dataset:
Proximate composition, phytochemical and antimicrobial activity of aqueous and ethanolic extracts of Hunteria umbellata on some clinical isolates
Authors: Udinyiwe C.O. , Aghedo E.S.
Published: March 2022

A medicinal plant is any plant which has therapeutic used and are used for drug production. The use of medicinal plants for traditional uses is well known in rural areas and many developing countries. This study was undertaken to evaluate the antibiotic and therapeutic importance of the extracts of Hunteria umbellata against selected clinical isolates known to cause diseases to man. Agar well diffusion method was used to determine the antibacterial activity of Hunteria umbellata. The proximate composition showed that carbohydrate with 71.55±0.10 % had the highest value. The elemental composition analyzed showed that Fe had the highest amount. The phytochemical screening of both aqueous and ethanolic extracts showed the presence of oxalate, phytate, tannins, flavonoids, saponins, alkaloids, phenols, cyanogenic glycoside and anthraquinones. The clinical isolates E. coli, S. pneumonia, S. pyogenes, S. aureus, Staphylococcus sp., P. aeruginosa, Micrococcus sp., Klebsiella sp., Proteus sp., Bacillus sp., S. epidermidis, Candida albicans, S. cerevisiae. The zone of inhibition of aqueous and ethanolic extracts in comparison with the conventional antibiotics showed that the extracts had better antibacterial properties. The results obtained showed the important use of H. umbellata in ethnomedicine.
A new species of Nephopterix Hübner, 1825 from the Canary Islands, Spain (Lepidoptera: Pyralidae: Phycitinae)
Authors: Larsen Knud
Published: March 2022

A new species is described from the Canary Islands in the genus Nephopterix Hübner, 1796 (Lepidoptera: Pyralidae: Phycitinae), Nephopterix subangustella sp. nov. The new species is closely related to Nephopterix angustella (Hübner, 1796) but differs by its slightly smaller size, more narrow wings and paler inconspicuous markings on the wing. In the genitalia the sacculus is more bent and the spines in the bursa are much larger. The larvae are found in flowers and seeds of Maytenus canariensis ((Loes.) Kunk. & Sund.). The adult moths, male and female genitalia of the two Nephopterix species are illustrated, along with the type locality. New records of N. angustella from Turkey and mainland Africa are published.
Costus speciosus J Koenig (Costaceae) exerts anti-proliferative effect on breast cancer cells via induction of cell cycle arrest and inhibition of activity of metalloproteinase-2
Authors: Bawakid Nahed O. , Abdel-Lateff Ahmed , El-Senduny Fardous F. , Alarif Walied M.
Published: March 2022

Purpose: To Investigate the antiproliferative effect of n-hexane-diethyl ether fraction of Costus speciosus (NP) on triple negative breast cancer (MDA-MB-231) cells, and the mechanism involved.

Methods: Maceration with methanol (CH3OH) was used for extraction of Costus speciosus rhizomes. Chromatographic separation was used to obtain the non-polar fraction (NP) via elution with n-hexane:(C2H5)2O at a volume ratio of 9:1. The cytotoxic effect of NP was evaluated against two breast cancer cell lines i.e., triple negative (MDA-MB-231) and positive ER (MCF-7) employing 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT) assay, and the IC50 values were estimated. Cell cycle was determined with flow cytometry, while the likely mechanism involved in the cytotoxic effect was investigated using comet assay, immunofluorescence, clonogenic and scratch assays, zymography and detection of the antioxidant markers.

Results: NP produced potent cytotoxicity against MDA-MB-231, with IC50 value of 4 ± 0.03 μg/mL, whereas its IC50 for MCF-7 was 27 ± 1.3 μg/mL. It induced apoptosis via cell cycle arrest at G1 phase. Moreover, NP markedly decreased levels of superoxide dismutase (SOD), reduced glutathione (GSH), and matrix metalloprotease-2 (MMP-2), in MDA-MB-231 cells. Moreover, it inhibited cancer cell migration and colony formation.

Conclusion: Non-polar fraction of Costus speciosus (NP) exerted cytotoxic effect on triple negative breast cancer cells (MDA-MB-231) and positive ER (MCF-7). It inhibited cancer cell migration and colony formation. Interestingly, NP arrested the breast cancer cell cycles at sub-G1 phase, inhibited SOD and MMP-2, and decreased GSH levels. It induced apoptosis via DNA damage, downregulation of mutant p53, and over-expressions of the cell cycle inhibitors p21 and p27.
Model statistic regional pentru estimarea diametrului de bază al molidului în funcție de diametrul cioatei la înălțimea de referință de 30 cm
Authors: Popa Ionel , Popa Andrei , Horvath Arnold , Ștețco Istrate , Korpos Attila
Published: March 2022

În practica silvică adeseori se impune estimarea diametrului de bază și a volumului arborilor pornind de la diametrul cioatei rămase după extragere. Elaborarea de tabele dendrometrice locale privind derivarea diametrului de bază funcție de diametrul cioatei reprezintă o necesitate pentru administrația silvică. În prezentul studiu s-a calibrat un model regresiv local, de tip parabolic cu modelarea varianței reziduale, pentru obținerea diametrului de bază la molid funcție de diametrul cioate cu înălțimea de 30 cm,  reprezentativ pentru fondul forestier administrat de Ocolul silvic de regim Gheorgheni. Setul de date utilizat pentru estimarea parametrilor modelului statistic este format din 4050 de arbori din 111 arborete, cu caracteristici biometrice variate. Modelul statistic propus și volumele unitare diferențiate pe clase de producție permite o evaluarea mai corectă a pagubelor provenite din tăieri ilegale, având o fiabilitate ridicată în condițiile fondului forestier administrat de OSR Gheorgheni.
Identificarea factorilor dăunători care afectează culturile forestiere – principii generale și un studiu de caz
Authors: Olenici Nicolai
Published: March 2022

Culturile forestiere din solarii, pepiniere, plantații etc. sunt afectate frecvent de numeroși factori dăunători și prevenirea sau limitarea pagubelor cauzate de acești factori necesită o diagnosticare corectă și rapidă a lor. Diagnosticarea corectă este însă un proces complicat și în literatura noastră de specialitate nu sunt prezentate informații cu privire la modul în care ar trebui să se procedeze, astfel încât să se ajungă la un diagnostic corect într-un timp cât mai scurt. În lucrarea de față sunt prezentați pașii unei abordări sistematice, meniți să faciliteze acest proces: obținerea imaginii de ansamblu sau înțelegerea contextului, analizarea unor eșantioane reprezentative prelevate din cultura afectată, analizarea în dataliu a organelor vătămate; analizarea și sinteza informațiilor obținute, respectiv stabilirea diagnosticului. Principiile generale sunt susținute de numeroase exemple din experiența autorului sau din literatura de specialitate. Pentru ilustrarea modului de aplicare a abordării sistematice în diagnosticarea dezechilibrelor fiziologice, a bolilor sau a vătămărilor cauzate de diverși factori, se prezintă - ca studiu de caz – felul în care s-a procedat pentru stabilirea cauzei nerăsăririi plantulelor de molid într-o cultură efectuată în solar. Aplicând, la acest caz concret, principiile menționate, s-au cules informații pe baza cărora au fost invalidate patru dintre ipotezele formulate în vederea explicării fenomenului menționat (semințele semănate au fost de calitate necorespunzătoare; germinarea semințelor nu s-a produs din cauza deficitului sau excesului de apă; plantulele nu au răsărit fiind afectate de frigul survenit după semănare; plantulele nu au răsărit din cauza vătămării lor în sol de către diverse organisme). Toate informațiile culese s-au coroborat în sensul validării celei de a cincea ipoteze, respectiv moartea semințelor aflate în procesul de germinare ca urmare a efectului toxic al substanței folosite pentru dezinfectarea patului germinativ (Basamid, care are ca substanță activă dazomet). Acesta este un exemplu elocvent pentru importanța pe care o are cunoașterea contextului în care s-a produs fenomenul studiat. Fără informațiile obținute în această fază a investigațiilor, un diagnostic corect și relativ rapid nu ar fi fost posibil.
Specialistul silvic Zeno Oarcea: ”Am văzut tinerețea fără bătrânețe”
Authors: Drăgoi Marian , Ciornei Laurențiu
Published: March 2022

A terminat Facultatea de Silvicultură ca șef de promoție, fiind unul dintre cei mai valoroși amenajiști ai generației sale. În 1964, cu ocazia unor amenajări din Masivul Retezat a reușit să extindă, prin amenajament, suprafața Parcului Național, de la 14.000 la peste 30.000 de hectare. Nu a reușit însă mai multe, deoarece autoritățile comuniste nu au dorit ca parcurile naționale să fie și administrate. Nu s-a lăsat și l-a contactat inclusiv pe Nicolae Ceaușescu care inițial i-a dat ”undă verde”, dar demersul a fost blocat de un activist din cadrul Direcției Păduri din minister. Între 1973 și 1978 a realizat întreaga structură de organizare și administrare a întregii rețele de parcuri naționale, cele 13 care sunt și astăzi : Buila-Vânturarița, Călimani, Ceahlău, Cheile Bicazului-Hășmaș, Cheile Nerei-Beușnița, Cozia, Domogled-Valea Cernei, Defileul Jiului, Munții Măcinului, Munții Rodnei, Piatra Craiului, Retezat, Semenic-Cheile Carașului. Toate eforturile depuse de silvicultorul Zeno Oarcea au fost desăvârșite în 2003, iar pentru stăruința sa este considerat Pionierul parcurilor naționale din România.
Un profesor bun reușește să explice și să se facă înțeles. Un profesor extraordinar reușește să inspire!
Authors: Palaghianu Ciprian
Published: March 2022

În 25 iunie 2021, Facultatea de Silvicultură a sărbătorit un astfel de profesor extraordinar. Universitatea „Ștefan cel Mare” din Suceava i-a acordat titlul de PROFESOR EMERITUS domnului Profesor universitar doctor inginer Radu Leontie Cenușă.Motivarea acestei distincții este fondată pe mai multe fapte:(i) rolul de creator de școală forestieră pe care Profesorul l-a avut. Și aici mă refer nu doar la rolul pe care l-a avut alături de domnul Radu Ichim, Nicolae Geambașu sau Ion Barbu în susținerea ideii de reînființare a Facultății de Silvicultură în Bucovina ci și la rolul în consolidarea colectivului și instruirea promoțiilor de silvicultori în spiritul respectului față de pădure;(ii) generoasa carieră didactică și științifică a domniei sale, activitatea sa de cercetare cuprinzând un număr impresionant de proiecte, cărți, articole sau comunicări recunoscute și apreciate de comunitatea științifică forestieră.
A cincea ediție a Conferinței Internaționale „Managementul integrat al resurselor de mediu” din 29 octombrie 2021, Suceava, România.
Authors: Coșofreț Cosmin
Published: March 2022

A cincea ediție a Conferinței Internaționale „Managementul integrat al resurselor de mediu” a avut loc pe 29 octombrie 2021 în Suceava, România. Cele mai importante sesiuni ale conferinței au fost: (i) Bioeconomia forestieră, (ii) Biodiversitatea pădurilor, silvicultura și starea de sănătate a pădurii , (iii) Ecosisteme forestiere și clima și (iv) Evaluarea, modelarea și managementul pădurilor. Prezentările au fost în conformitate cu preocupările societății despre mediu, păduri și schimbările climatice ce evidențiază faptul că societatea trebuie să accepte iminența transformărilor importante ale mediului înconjurător.
Academicianul Victor Giurgiu și contribuția sa la dezvoltarea învățământului universitar silvic din Bucovina
Authors: Horodnic Sergiu Andrei , Roibu Cătălin-Constantin
Published: March 2022

Profesorul universitar Victor Giurgiu, cu o remarcabilă şi prolifică activitate prin ştiinţă şi pentru știință, a fost unul din cei mai aprigi promotori și susținători ai calității actului didactic și ai cercetării științifice autentice. La începutul anilor ’90, academicianul Victor Giurgiu a contribuit definitoriu la crearea şi dezvoltarea şcolii silvice superioare în proaspăt înfiinţata universitate suceveană.

Sunt subliniate cele mai reprezentative contribuţii ale domnului academician Victor Giurgiu, în măsură să contureze personalitatea sa ştiinţifică şi academică, însoţite de prezentarea câtorva repere biografice.

Lucrarea este un omagiu încărcat de recunoştinţă al întregului colectiv al Facultăţii de Silvicultură din Suceava a cărei evoluţie a fost puternic marcată de activitatea distinsului magistru.
On Statistical Limit Points in a Fuzzy Valued Metric Space
Authors: Aytar S. , Yamancı U. , Gürdal M.
Published: March 2022

We introduce the concepts statistical cluster and statistical limit points of a sequence of fuzzy numbers in a fuzzy valued metric space. Then we obtain some inclusion relations between the sets of limit points, statistical limit points and statistical cluster points for a sequence of fuzzy numbers.
One Approach to Solve Some Problems of Management Under Uncertainty
Authors: Tsabadze Teimuraz , Prangishvili Archil
Published: March 2022

We consider the approaches to making decisions for control problems in nonstandard situations with a lack of the previous experience and incomplete knowledge of the considered problem. In such cases we usually cannot do without expert evaluations which lead to the process of group decision-making, and it becomes necessary to solve a problem of alternatives aggregation. It has been proposed to solve such problems by means of fuzzy sets. The approach is based on the coordination index and the similarity of finite collections of fuzzy sets and takes into account the specific character of the fuzzy aggregation operator. The approach is discussed and its algorithm is presented. An example of the application of the proposed method is given.
A DFA Approach for Motion Model Selection in Sensor Fusion
Authors: Bostanci Erkan
Published: March 2022

This paper investigates the use of different motion models in order to choose the most suitable one, and eventually reduce the Kalman filter errors in sensor fusion for user tracking applications. A Deterministic Finite Automaton (DFA) was employed using the innovation parameters of the filter. Results show that the approach presented here reduces the filter error compared to a static model and prevents filter divergence.
Applying Fuzzy Delphi Method and Fuzzy Analytic Hierarchy Process for Ranking Marine Casualties
Authors: Etebarian Akbar , Shirvani Alireza , Soltani Iraj , Moradi Ali
Published: March 2022

Marine accidents, particularly those that involve pollution and large fatalities, bring into question the safety of shipping and the quality of ships and their crews. Whether or not such questions are justified, it is marine accidents that provide a poor image of the industry, which attract considerable attention. Incidents that particularly attract attention are those causing loss of life, pollution of the environment and the loss of ship and or cargo. Usually, People have a tendency to focus on the consequences of an accident rather than its root causes, so MCDM1 could improve to find the root cause elements by providing more precise decision parameters. Due to the complexity of Marine accident investigation, this study aims to provide a systematic approach to determine the degree of most influence parameters (cause and effect) in accident occurrence, in order to improve marine safety in direction of Good Governance; in the study two phase procedures are proposed. The first stage utilizes Fuzzy Delphi Method to obtain the critical factors of the Marine Accident Investigation by interviewing the related connoisseurs. In the second stage, Fuzzy Analytic Hierarchy Process is applied to pair fuzzy numbers as the measurable indices and finally to rank degree of each influence criterion within accident investigation. This study considers 1 Goal, 4 Aspects and 31 Criteria (Parameters), and establishes a ranking model that provides decision makers to assess the prior ordering of reasons and sorts by most effective parameter involved Marine Accident occurrence. The empirical study indicates that the "" People, Working and living conditions, Effect "" is the high ranking aspect and ""Ability, Skills and knowledge of workers"" is the most important evaluation criterion considered in overall experts view derived from Fuzzy Delphi Analytical Hierarchy Processing (FDAHP). The demonstration of how the prior order of accident maker parameters of connoisseurs is addressed as well. Therefore, ranking the priority of every influencing criterion (parameter), shall help the decision makers in marine transportation, to emphasize the area to improve and act accordingly to prevent future marine accidents.
Multi-level Image Classification Using Fuzzy Petri Net
Authors: Ivasic-Kos M. , Ribaric S. , Ipsic I.
Published: March 2022

For a multi-level image classification, a knowledge representation scheme based on Fuzzy Petri Net with fuzzy inference algorithms is used. A simple graphical Petri net notation and a welldefined semantics displaying the process of reasoning through inference trees are used for visualization of the knowledge base and explanations of derived conclusion. Used knowledge representation formalism has the ability to show a probability of concepts and relations. The procedures of image multi-level classification using fuzzy recognition and inheritance algorithms on a knowledge representation scheme, as well as experimental results of image semantic interpretation, are presented.
Comparison of Ki-67 index values between patients with operated giant prolactinomas and macroprolactinomas
Authors: CANDER Soner , ÖZ GÜL Özen
Published: March 2022

Objective: Data on whether there is a histopathological difference in cellular features as determined with Ki-67 between giant prolactinomas and smaller macroprolactinomas are not fully clear. In this study, we aimed to compare Ki-67 value between patients followed-up with diagnosis of macroprolactinoma and giant prolactinoma and operated for different reasons.

Methods: Files of 15 patients with giant prolactinomas and 16 patients with macroprolactinomas who had been operated with various indications were retrospectively evaluated. Similar number of patients were included to carry out a reasonable analysis. Patients’ demographics (age and gender), age at the time of diagnosis, tumor diameter during the diagnosis and at the last follow-up visit, initial and last PRL and Ki-67 values were compared between the groups. Ki-67 value was studied with MIB-1 monoclonal antibody method.

Results: The mean age and gender were similar between the patients with macroprolactinomas and giant prolactinomas. The mean longest tumor diameter at diagnosis was measured as 18.13±9.42 mm in the macroprolactinoma and 47.07±9.70 mm in the giant prolactinoma group (p
Evaluation of Patients Performed with Saline Infusion Test with a Pre-Diagnosis of Primary Hyperaldosteronism
Authors: ATEŞ Coşkun , ADA Gül , MERCAN SARIDAŞ Filiz , AYDEMİR Ensar , HOCAOĞLU Erhan , ÖZ GÜL Özen , CANDER Soner , ERSOY Canan , ERTÜRK Erdinç
Published: March 2022

Background: Primary hyperaldosteronism (PHA) is a primarily treatable cause of arterial hypertension characterized by low plasma renin and high aldosterone levels. The prevalence of secondary hypertension as a common endocrine cause is 5-13%. The plasma aldosterone/renin ratio (ARR) is the best available method for PHA screening. One or more confirmatory tests may be required to confirm or exclude patients' diagnoses. One frequently used confirmatory test is the saline infusion test (SİT). We aimed to screen the patients who underwent SİT with the preliminary diagnosis of PHA and to compare the results of the patients diagnosed with essential hypertension (EH) and PHA.

Material and Methods: Seventy-seven patients with a history of drug-resistant hypertension or unexplained spontaneous or diuretic-induced hypokalemia or adrenal incidentaloma, or a family history of early-onset hypertension or cerebrovascular accident at a young age (0.05). Basal plasma aldosterone (p
Retrospective evaluation of radioactive iodine ablation therapy in the Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) and Thyroid tumors with uncertain malignity potential
Authors: GÖKTUĞ Mehmet Refik , ÖZ GÜL Özen , CANDER Soner
Published: March 2022

Background: Noninvasive Follicular Thyroid Neoplasm (NIFTP), Well differantiated thyroid tumor with uncertain malignity potential (WDT-UMP), follicular thyroid tumor with uncertain malignity potential (FT-UMP), and Hurtle cell neoplasia with uncertain malignity potential (HCN-UMP) have been included in the classification of thyroid tumors by WHO, with the incidence of thyroid cancer increasing every passing year. There is no consensus regarding the follow-up and treatment processes of these tumors. Our study aims to shed light on our clinical practice by evaluating the follow-up processes of the groups with and without radioactive iodine ablation in patients followed up with these diagnoses.

Material and Methods: The 49 patients older than 18 years of age and followed for at least 12 months, who were performed subtotal and total thyroidectomy between 2015 and 2020 and were diagnosed with WDT- UMP, FT-UMP, HCN-UMP, and NIFTP according to histopathological examination were included to the study.

Results: Tumor type rates did not differ between the groups that received and did not receive RAI treatment (p=0.361). The mean follow-up period did not differ between the groups that received and did not receive RAI treatment. Also the rates of RAI treatment according to tumor size did not differ (p=0.413). Tumor size was larger than 4 cm in 13 patients, and 1 patient from this group had received RAI treatment. Recurrence was not detected in the 49 patients included in our study who received or not receive RAI treatment.

Conclusions: Some studies recommend giving RAI to these borderline thyroid tumors larger than 4 cm. But in our study no recurrence was detected in patients who did not receive RAI. That supports the view that patients could be followed without RAI treatment even if they are large tumors.
Retrospective Evaluation of the Efficiency of Therapeutic Plasmapheresis in Thyrotoxic Patients
Authors: MERCAN SARIDAŞ Filiz , ZOR TURNA Tugce , AYDEMİR Ensar , ATEŞ Coşkun , HOCAOĞLU Erhan , CANDER Soner , ÖZ GÜL Özen , ÖZKALEMKAŞ Fahir , ERTÜRK Erdinç , ERSOY Canan
Published: March 2022

Background: Therapeutic plasma exchange (TPE) is a treatment method that can be used to provide euthyroidism before permanent treatment in patients with severe thyrotoxicosis, in cases of thyroid storm and in cases where antithyroid drug (ATD) cannot be used due to side effects or ineffectiveness. This study presented our results and experience on TPE in thyrotoxic patients. Material and Methods: The data of 10 patients who underwent plasmapheresis for thyrotoxicosis in Bursa Uludag University Faculty of Medicine Endocrinology Clinic were retrospectively analyzed and compared with the literature. Results: Ten patients, 6 female and 4 male, were included. The cause of hyperthyroidism was Graves’ disease in 8 patients and toxic multinodular goiter (TMNG) in 2 patients. It was observed that the reason for applying plasmapheresis in the patients was primarily due to toxic hepatitis. The mean number of plasmapheresis required to maintain euthyroidism was 4 (1-8). While no difference was found between the thyroid-stimulating hormone (TSH) results before and after TPE, free T4 (fT4) and free T3 (fT3) values were statistically significantly lower after TPE. It was observed that the leukocytes were considerably higher after TPE and the sodium and calcium values were markedly lower after TPE in the patients. After TPE, 7 patients underwent total thyroidectomy, 1 patient received radioactive iodine (RAI) treatment, and 2 were discharged with ATD treatment. Conclusions: TPE is an effective and safe treatment option that can be applied in cases where it is necessary to provide rapid euthyroidism before permanent treatments or non-thyroid surgical procedures or to treat life-threatening thyrotoxicosis. It requires experience in application and follow-up and provides rapid euthyroidism when performed in experienced centres.
A Single Center Retrospective Analysis of Patients with Recurrent Papillary Thyroid Carcinoma Undergoing Radiofrequency Ablation
Authors: HOCAOĞLU Erhan , AYDEMİR Ensar , ATEŞ Coşkun , MERCAN SARIDAŞ Filiz , NAS Omer Fatih , İNECİKLİ Mehmet Fatih , CANDER Soner , ÖZ GÜL Özen , ERTÜRK Erdinç , ERSOY Canan
Published: March 2022

Background: Radiofrequency ablation (RFA) is used in selected patients with recurrent or metastatic thyroid cancer who have high surgical risk or do not accept surgical treatment. However, long-term follow-up data are limited. Here, we present our single-center experience with the use of RFA in the treatment of recurrent or metastatic papillary thyroid carcinoma (PTC).

Material and Methods: Patients who underwent RFA for recurrent or metastatic PTC at Bursa Uludag University Faculty of Medicine between September 2014 and January 2021 were included. The data in the endocrinology outpatient clinic follow-ups of the patients were analyzed retrospectively.

Results: A total of 10 patients, 11 RFA procedures, and 13 residual or metastatic sites were evaluated. The mean age was 44.50±14.04 years. The mean largest diameter of the tumor in which RFA was applied was 11.85±5.95 mm. Patients developed no major complications. Two patients experienced minor complications. The mean follow-up duration was of 51.20±19.86 months. During the follow-up period, 12 (92.30%) of 13 RFA sites completely disappeared. In one patient (7.69%) residual tumor tissue was detected after RFA. There was no recurrence at the procedure site. A significant decrease was found in the largest diameter of the treated regions after RFA (p=0.002). Thyroglobulin and anti-thyroglobulin levels were not significantly different before and after RFA (p=0.44 and p=1.00, respectively).

Conclusions: RFA is highly effective and safe for locally recurrent PTC. It shows promise as an alternative to surgery to control locoregional recurrence of PTC.
Comparison of Clinical Progress of Covid-19 Patients Followed in the Hospital by Vaccination Status
Authors: YİĞİT Sidelya Ecem , GÖKMEN İffet Beril , OKUTURLAR Yıldız , KÖKSAL İftihar
Published: March 2022

Background: Although Covid-19 vaccines cannot prevent infection with SARS-CoV-2, they do allow infected people to have a milder illness. In unvaccinated people, the disease progresses more severely and the disease can be fatal. Both inactivated (Sinovac) and mRNA (Biontech-Pfizer) vaccines are used in Turkey. In this retrospective study, clinical course, radiological involvement and some laboratory parameters that are important for Covid-19 were compared in unvaccinated and vaccinated patients who were infected and followed up in the hospital.

Material and methods: Patients between the ages of 17-95 who were hospitalized in the Covid-19 isolation wards between June 2021 and November 2021 were included in the study. Various datas of patients were scanned retrospectively from the hospital registry system.

Results: While there was no difference in the mean age, highest fibrinogen, D-dimer, ferritin, creatinine, interleukin-6 (IL6) values and Covid-19 PCR test negative times besides antibody levels, Group 2 (7.8 days) was found to be discharged significantly earlier than Group 1 (12.69 days) (p=0.046). There was a significant difference in low-dose thoracic computed tomography (CT) findings between the two groups (p= 0.023).

Discussion: Our study results showed that regardless of the type of vaccine, vaccination against Covid-19 reduces hospitalization rates, length of stay and prevents serious involvement in the lungs.
Medication Errors and Potentially Inappropriate Medication Use in Elderly Patients Admitted to the General Internal Medicine Outpatient Clinic of a University Hospital
Authors: PESEN Ercan , DEMİRCAN Celaleddin , SIĞIRLI Deniz
Published: March 2022

Background: The frequency of chronic diseases, number of drugs used, and number of medication errors have increased in the elderly. In this study, we aimed to determine the prevalence of potentially inappropriate medication (PIM) use and medication errors in elderly patients admitted to a university hospital and to identify the influencing factors.

Material and Methods: In this prospective cross-sectional study, the patients’ characteristics, drug use patterns, and medication errors in the previous month were recorded in detail. Following this, PIM use was assessed according to the 2015 Beers Criteria.

Results: A total of 721 elderlay patients (60.9% female and 39.1% male) were included in this study. The mean number of drugs used by the patients per day was 4.6±2.8 and the rate of polypharmacy was 49.4%. The rate of medication errors was 54.2%, that of PIM use was 30.1%, and that of adverse drug reactions was 22.5%; these rates were higher in patients with polypharmacy. The most common medication error, PIM use, and adverse drug reaction were the omission of a daily dose (36.5%), inappropriate use of proton pump inhibitors (10%), and gastrointestinal system-related symptoms (7.7%), respectively. Diabetes mellitus and depression were found to be independent factors associated with medication errors.

Conclusions: In the present study, patient-related medication errors, PIM use, and adverse drug reactions were more frequently observed in elderly patients with polypharmacy. In addition, medication errors were more commonly observed in elderly with diabetes mellitus and depression.
Radiotherapy could increase the efficacy of immunotherapy in non-small cell lung cancer
Authors: OCAK Birol , SARIHAN Süreyya , ŞAHİN Ahmet Bilgehan , DAKİKİ Bahar , CANER Burcu , GÜLŞEN Kemal , TANRIVERDİ Özgür , DELİGÖNÜL Adem , ÇUBUKÇU Erdem , EVRENSEL Türkkan
Published: March 2022

Background: In non-small cell lung cancer (NSCLC), immunotherapy is a treatment option in patients without targetable mutations in second and later lines. Nevertheless, there is no validated test that can predict immunotherapy response.

Material and Methods: Our study aimed to investigate the effect of radiotherapy (RT) on survival in patients with NSCLC receiving immunotherapy after first-line chemotherapy. Twenty-five patients diagnosed with NSCLC and received immunotherapy after at least one previous chemotherapy line were included in our study.

Results: The median age of the patients was 61.7 (26.6-81.2) years. 19 (76%) patients were male. 11 (44%) of the patients had received immunotherapy in the second-line and 14 (66%) in ≥3 lines. Patients had received a median of 5 cycles (1-27) of immunotherapy. RT to immunotherapy interval was 6.4 months (1.0-11.8). Partial response was observed in 12 patients, stable disease in 8 patients, progression in 1 patient, and hyperprogression in 4 patients. Median progression-free survival (PFS) was 4.4 months (95% CI; 3.2-5.6), and median overall survival (OS) was 16.4 months (95% CI; 5.6-27.3). 14 (56%) of the patients had received RT. RT was administered to 12 patients before immunotherapy, and two patients received RT to bones during immunotherapy. The patients who received RT had statistically longer PFS (4.9 vs 3.9 months, p=0.012) and OS (18.7 vs 7.3 months, p=0.023) comparing those without RT.

Conclusions: Our findings showed that RT significantly improved the survival in patients who received immunotherapy, pointing that RT may have an influential role in immunotherapy response.
Process of Life Cycle Installation of Wastewater Treatment and up to Water Reuse
Authors: Tampubolon Frances Roi Seston , Yuwono Arief Sabdo , Tambunan Armansyah Halomoan , Achsani Noer Azam
Published: March 2022

The life cycle assessment (LCA) of the wastewater treatment plant (WWTP) has several categories in the resulting impact analysis. One of them is a wastewater treatment plant on campus or university. Various emissions from WWTP and their impact factors are analyzed using software and utilizing the Eco-inventory database. Recycled water from factories has a positive impact on the categories assessed. System treatment overrides the effects of recycled water in other types such as potential terrestrial eco-toxicity, global warming potential, particulate matter formation, fossil depletion potential, and others. However, untreated sewers’ social effects and the environmental impact of compost generated by the system have not been thoroughly analyzed by a more holistic analysis. By using the LCA method, these results can be seen in Enim River’s environment expressed in GWP units (global warming potential) and human health expressed in ODP units (Ozone Depletion Potential). Several studies have also been conducted on LCA, which has problems with wastewater. One of the most recent research analyses various wastewater treatment strategies, such as aerobic against anaerobic, chemical versus chemical, and biological combinations. The Enim River is found in the Indonesian province of South Sumatra. The Muara Enim Regency area is where the river flows from upstream to downstream. The Enim River is a child of the Lematang River. The GWP value had a GWP of 16% before being treated in wastewater, and it had a GWP of 41.3% after being treated with sewage. This result means that treating wastewater requires energy to do so. Before treatment, the MDP value was 10.4%, and after treatment was 20.4%. However, further action after the management of wastewater gives significant value to the assessment of GWP, MDP, and ODP. The three results provided a reduction value for the reuse of treated water and reused as water needs.
Classroom engagement through short stories and motivational messages
Authors: Kumar Santosh , Haque Sanjana , Zhou Lina , Spivey Christina A
Published: March 2022

Objective: The objective of this study is to introduce short stories and motivational messages on soft skills in pharmacy didactic courses to improve classroom engagement.         Methods: Surveys were then conducted on the impact of students’ understanding of soft skills and their impact on classroom engagement.   Results: The survey results from the two classes (2022 and 2023) of first year students showed that they gained an understanding of soft skills appropriately. The strategy also improved their classroom engagement and well-being. A further survey from a class of 2023 third year students indicated the strategy continued to be helpful in subsequent years. The results from students’ feedback also showed that students generally appreciated the strategy, and it helped them stay positive and engaged in the classroom.     Conclusion: Overall, the study concluded that this unique delivery of soft skill information helped students in classroom engagement and helped them learn various soft skill sets.
Aeromonas allosaccharophila, an emerging opportunist pathogen for farmed hybrid sturgeon (Acipenser baerii × Acipenser schrencki), in southwest China
Authors: Huang Ya , Liu Hongli , Geng Yi , Chen Defang , Ouyang Ping , Yang Shiyong , Yin Lizi , Luo Wei , Wang Jun , Huang Xiaoli
Published: March 2022

Aeromonas allosaccharophila belongs one of the causative agent of Aeromonas disease in teleosts. Here, we reported on multiple outbreaks of A. allosaccharophila with mortality up to 80% in farmed hybrid sturgeon in Sichuan, China, from 2019 to 2021. This was the first study to A. allosaccharophila from diseased hybrid sturgeons by phenotypic characterization and 16S rRNA analysis. The typical clinical signs of these fish were intestinal segments empty and often with yellow mucus or swelling. Histopathological observation of diseased fish infected with A. allosaccharophila showed the intestinal villus structure disappeared and the intestinal mucosa epithelium was necrotic and shed. Experimental infection indicated that A. allosaccharophila was the pathogen responsible for the mortalities. Antibiotic sensitivity test results showed that A. allosaccharophila was resistant to ampicillin, neomycin, tetracycline, and penicillin, while sensitive to sulfamethoxazole, streptomycin, florfenicol, enrofloxacin, and cefoxitin. Our

findings provide references for the disease diagnosis and treatment.
Pengembangan Kemampuan Mengajar Tutor dengan Metode Student Centered Learning Pada PKBM Bumi Literasi
Authors: Soraya Grabiella Dinamika  , Dewi Shinta Wulandari Lubis
Published: March 2022

The government through the Ministry of Education and Culture has facilitated the community to be able to improve education and living standards through non-formal education (PNF), one of which is called the Community Learning Activity Center (PKBM). PKBM can organize Equality Education Package A/B/C, the legality is regulated in Law no. 20/2003. In organizing this package program, teaching and learning activities in PKBM are guided by teaching staff who are called tutors. However, it is found that tutors who have diverse educational backgrounds, so the skills and teaching methods applied are still very simple and monotonous. This was also found in the PKBM Bumi Literasi located in Sigara-gara Village, Patumbak District, Deli Serdang Regency. Based on the results of interviews and on-site observations, the tutors explained that such teaching methods had an impact on decreasing the learning interest of the learning community. Based on this, the team assumed the need to introduce the Student Centered Learning (SCL) teaching method to all PKBM Bumi Literasi tutors. So, the purposes of community service are to 1) introduce the methods, benefits, and functions of SCL to tutors, 2) explain the types of SCL methods, and 3) provide strategies and recommendations in applying SCL in the learning process. From the results of community service activities, the N-gain number is 0.70, which is normalized into the high category. This shows that after getting knowledge and exposure to material about SCL, the knowledge and teaching ability of PKBM Literacy tutors has increased
Ekspansi Pasar dan Peningkatan Kualitas UMKM Sepatu Desa Gemawang, Kabupaten Semarang Melalui Kegiatan Pelatihan
Authors: Winarti Diah , Annisa Peby Amalya  , Febriana
Published: March 2022

The pandemic that occurred about 1 year ago had an impact on the decline in the economy. Small business units in Gemawang Village felt the impact, such as decreased sales, capital, hampered distribution, and difficulty in raw materials. Digital-based business development is an alternative to saving the business unit sector during the Covid-19 pandemic. Business units in Gemawang Village experienced various problems such as difficulties in marketing batik shoe products online due to the lack of workers and the ability to utilize technology. The purpose of community service activities is to increase the amount of production from each business unit along with increasing turnover, modifying packaging, prices, shapes, expanding product marketing by selling through digital markets from related units, improving branding,  educating each unit in the use of e-commerce., marketing, and good packaging, optimizing the utilization of village potential and increasing the income of each production unit and the community around Gemawang Village. The results of community service show results that can increase people's income through the production of shoes that look more varied, attractive and fashion. The model is not monotonous and when used it is more comfortable on the feet with varied and quality packaging. Community service activities carried out by the IAAS UNDIP team to the community in Gemawang village are very useful and can increase the amount of production from each business unit along with an increase in turnover. People are highly motivated to produce their shoes by modifying the packaging, model, and shape. Thus, it will expand product marketing, increase branding, so that it can increase the income of the Gemawang village community
Pelatihan Tatacara Sholat bagi Anak-anak di Masjid Jamik Tunggal Bhakti Kelurahan 20 Ilir D I Kecamatan Ilir Timur 1 Palembang
Authors: Nurbuana  , Sri Safrina  , Fitriana  , Zaimuddin
Published: March 2022

Prayer is one of the obligatory acts of worship for Muslims. In carrying out prayers, of course, one must know about the conditions, pillars and correct prayer procedures so that prayers do not become in vain. Based on the observations made, there are still children who pray without knowing about the conditions, pillars and correct procedures due to the lack of motivation and knowledge about prayer that they get. Hi, this is the background for carrying out community service regarding prayer procedures for children. The service activities were attended by 30 children consisting of boys and girls. The purpose of this activity is for children to gain knowledge about good and correct prayer procedures, so that later they can practice it in everyday life. The form of this activity is in the form of training that provides added value for the community, especially children, which is delivered through the lecture method, question and answer and demonstration (practice). The results of this community service went well, were successful and received good support in the Jami' Tunggal Bakti Mosque community
Pelatihan Pemanfaatan E-Commerce Dalam Meningkatkan Pendapatan Ekonomi Muslimah Masjid Darul Hannan
Authors: Nursobah  , Arfyanti Ita
Published: March 2022

Every service activity carried out by lecturers is expected to help the community in facilitating the community in helping to increase economic income during this pandemic, this service aims to provide insight to Muslim women at the Darul Hannan Mosque where participants are teenagers to mothers who participate in the organization regarding the use of internet networks and social media, as for ways that can be done to improve the economy, namely by taking advantage of the availability of e-commerce in marketing various types of products and services, the stages carried out in a service are creating training forums such as workshops where the activity will explain the benefits of e-commerce. -commerce, scope and achievements of e-commerce, goals of e-commerce and participants are taught directly from account creation to transaction processing. This activity can be said to introduce communication media, technology and the ease of starting a business in the era of digital technology. The results obtained are the audience's knowledge of the type of e-commerce and the ease of use of e-commerce
Pemanfaatan Aplikasi Google Form Sebagai Media Ujian Online Seleksi Karyawan Baru PT Indeks Media Teknologi Pada Era Pandemi
Authors: Ita Arfyanti  , Nursobah Nursobah
Published: March 2022

The era of the pandemic or a situation in which many countries have locked down in various regions due to the spread of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) or the covid-19 virus and caused a lot of economic chaos due to the long suspension of activities that led to ordered by the government to break the chain of the spread of the virus, the pandemic era caused many companies to go out of business and led to an increase in the number of unemployed. PT Indeks Media Teknologi is one of the companies that is developing in distributing and producing goods in the form of equipment and gas cylinder safety which is widely used by the community, the high number of unemployed in the pandemic era, has led to a high rate of submission of job applications to companies, especially the private company PT Indeks Media Teknologi. The selection of employee recruitment certainly has certain requirements, one of which is by giving prospective employees several written knowledge exams to see the prospective employees according to the needs of the company, this can be done by using online media to provide access to prospective new employees in taking the exam so that the the company did not violate the provisions of the lockdown. One application that can be used as an online exam provider facility is Google Form where this application is a feature provided by Google for free by having various models and types of exam methods. Through the provision of training on the benefits of using google forms, PT Indeks Media Teknologi was able to solve problems in the difficulty of recruiting new employees in giving written exams during the pandemic era
Pelatihan Pemantapan Sistem Operasi Linux Sebagai Bekal Persiapan Uji Kompetensi Ujian Nasional Tingkat Kejuruan
Authors: Agus Perdana Windarto  , Anjar Wanto  , Mesran Mesran
Published: March 2022

According to the title of the program, the method of ipteks maintenance that is used is learning and exploring the Linux Operating System. Pelatihan keterampilan ditunjang dengan ceramah, tanya jawab, dan juga langsung praktek di laboratorium komputer. Modul pelatihan diberikan kepada peserta sebagai alat kegiatan praktek di laboratorium. The goal of this program's implementation is to improve the performance of SMK UISU students through the use of word processing applications, as well as to teach SMK UISU students about the Linux Operating System, in order to reduce the gap between SMK UISU student performance and the national average. Based on the results of the evaluation and the lessons learned during the implementation of the P2M program, we can conclude that the program is capable of providing significant and timely benefits to khalayak anak-anak panti asuhan, which has become a khalayak sasaran in the process. Pelatihan like this is a very effective way of providing new knowledge and understanding in the field of information technology in the context of the various learning processes that take place in schools across the country
Pendampingan Berbasis Media Sosial Pada Penderita Covid 19 dengan Isolasi Mandiri di Kecamatan Margadana Kota Tegal
Authors: Umriaty  , Seventina Nurul Hidayah  , Meyliya Qudriani
Published: March 2022

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is a new type of coronavirus that has never been previously identified in humans. The virus is mainly transmitted from symptomatic people to other people who are in close proximity through droplets. Social restrictions are the government's policy choice as an effort to reduce transmission. People with COVID-19 have an obligation to limit their interactions with other people. The option of self-isolation at home is taken for patients with mild symptoms. This activity aims to provide assistance to Covid-19 patients. Assistance is provided through social media, namely Whatsapp. There were three families who were given assistance in this activity. The information provided is the treatment of Covid-19 patients at home and the prevention of transmission to family members. In addition to providing information, activities are also carried out in the form of partnerships with the Sumurpanggang Health Center for reporting patient conditions. To meet nutritional needs, partnerships are made with mobile vegetable traders. Assistance activities are carried out since the patient is confirmed positive for Covid-19 through an antigen examination for up to 14 days. As a result, Covid-19 patients were able to go through a period of self-isolation and no new cases were found in family members. Suggestions for the community are optimizing the right information about the care of Covid-19 patients who are self-isolating at home