bluuebunny/crossref_metadata_2025 huggingface dataset:
Kebijakan Hukum Pelayanan Kefarmasian Di Indonesia (Suatu Tinjauan Penguatan Dan Perlindungan Hukum Apoteker Dan Pasien Pada Layanan Kefarmasian)
Authors: Wahyudin Wahyudin , Nufus Lale Syifaun
Published: June 2022

Dalam upaya percepatan peningkatan derajat kesehatan masyarakat Indonesia yang salah satunya dapat terpenuhinya perlindungan bagi pasien pada layanan kefarmasian, maka tentu peran tenaga farmasi di dalam diskursusnya salah satu faktor pendukung utama di satu sisi. Persis pada posisinya yang strategis tersebut di sisi lain, isu hukum penting yang dipertanyakan ialah bagaimana bentuk kebijakan Pemerintah kepada para tenaga farmasi di Indonesia, yang dalam hal ini terkait dengan sifat kewenangan, hak dan kewajibannya. Atribut-atribut hukum yang demikian adalah entitas penting yang dapat mempengaruhi jaminan eksistensi tenaga farmasi sebagai pembantu pemerintah dalam ikhtiar percepatan peningkatan derajat kesehatan masyarakat Indonesia. Selain itu kebijakan bentukan standar pelayanan kefarmasian bagi pasien juga merupakan entitas yang sangat penting sebagai tolok ukur yang turut serta mempengaruhi signifikansi dalam terpenuhinya kepuasan layanan kesehatan yang memadai bagi masyarakat. Penelitian ini menggunakan metode penelitian hukum normatif. Bahan hukum yang digunakan yaitu bahan hukum primer dan sekunder. Bahan hukum primer yaitu Undang-Undang, dan bahan hukum sekunder yaitu buku dan jurnal yang berkaitan dengan penelitan ini.
Pediatric scorpionism in southwest Turkey: the experience of a training and research hospital
Authors: ÇALIŞKAN Duygu , KUYBULU Ayça Esra Akkaya
Published: June 2022

Aim: The aim of this study was to evaluate the clinical and laboratory features and prognosis of scorpion stings in children.Methods: This was a retrospective study of children with scorpion stings, who were admitted to the pediatric emergency department in Alanya Alaaddin Keykubat University (ALKU) Training and Research Hospital between the 1st of January 2019 and the 31st of December 2020. Demographic data, admission date, time periods from sting to admission to hospital and geographical location in which the sting occurred were recorded. Recordings were also made of the affected body sites, local and systemic signs and symptoms of envenomation, results of hematological and biochemical laboratory tests, management, length of hospital stay and outcome.Results: In total, medical records of 111 children were reviewed. Patients were separated according to the clinical findings into three groups, seventy patients (63.1%) with mild symptoms and thirty-four patients (30.6%) with moderate symptoms, seven patients (6.3%) with severe symptoms. There was one exitus due to scorpion stings in the study period. Forty-one (37%) patients were hospitalised, and seven patients (6.3%) were hospitalised in the pediatric intensive care unit. Five patients (4%) received doxazosin and nineteen (17%) patients had antivenom therapy. Hospitalization in the intensive care unit was necessary for seven cases. No patient exhibited sequelae at the hospital discharge.Conclusions: Scorpion stings in our region mostly result in mild envenomation. Doxazosin, an analog of prazosin more readily available in our country, can be considered as a treatment option in serious scorpion envenomations with significant sympathetic symptoms.
Inovasi Alat Pemanggang Berbahan Bakar Elpiji Untuk Rumah Tangga
Authors: Surya Awang , Nurkholis Nurkholis , Sholih Hilman
Published: June 2022

The most common method used in grilling food is by burning charcoal and food ingredients such as fish and meat, heated from the heat of the charcoal burning. This charcoal grill has the disadvantage that it will produce pollutants into the air. Technically, charcoal grills are more complicated to implement, because during the grilling process the fire must be continuously controlled so that it does not go out. Charcoal grilled food will also get dirty easily. This activity is carried out with the aim of getting a grill design that is easy to operate at home. The method used is engineering research. The activities undertaken are literature study, field observation and design. The result of this activity is the design of a grill that can be operated at home with ease.
Особливості застосування безпілотних літальних апаратів при виконанні завдань логістичного забезпечення військ в сучасних збройних конфліктах
Authors: Леках А. А. , Гурін О. М. , Старцев В. В. , Гурін І. О. , Просяник В. В.
Published: June 2022

Розглянуто можливі області застосування безпілотних літальних апаратів в системі логістичного забезпечення Збройних Сил України. Проведено аналіз існуючих видів безпілотних літальних апаратів, описано їх особливості застосування. Проведено аналіз закордонного досвіду використання та розробок безпілотних технологій в області вантажних перевезень та евакуації персоналу. Визначено переваги безпілотних літальних апаратів при поєднанні з традиційними засобами переміщення та доставки матеріально-технічних засобів. Розглянуто перспективні сфери застосування безпілотних авіаційних технологій, які направлені на підвищення ефективності системи логістичного забезпечення військових частин і окремих підрозділів при веденні операцій (бойових дій) у сучасних збройних конфліктах.
Огляд та аналіз сучасних радіотехнічних систем навігації
Authors: Дукін Г. Ю. , Карлов Д. В. , Висоцький О. В. , Коробецький О. В.
Published: June 2022

У роботі проводиться огляд та аналіз радіотехнічних систем для ближньої навігації, які застосовуються або можуть бути застосовані для вирішення навігаційних задач у військовому та цивільному сегменті авіації України. Висвітлений сучасний стан комплектування наземними  навігаційними системами підрозділів військової і цивільної авіації, розглянуті проблеми переходу на нові радіотехнічні системи, наданий зрівняльний аналіз тактико-технічних характеристик систем, які представляють найбільший інтерес для військової авіації.
Medication use evaluation: The impact of introducing Nalbuphine on hospital management of Meperidine
Authors:   Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Tsai I-Hsuan , Hu Hsin-Yueh ,   Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Kuo Chen-Chun ,   Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Cheng Kuang-I ,   Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Lu Ying-Hao ,   Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan,   School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
Published: June 2022

Meperidine was often used for postoperative pain relief, but it has addictive and neurotoxic side effects. In order to reduce the use of Meperidine and meet the needs of clinical use, the hospital started using Nalbuphine in August 2018, and the effectiveness for about three years was analyzed with the expectations of reducing the risk of Meperidine use and improving the safety of analgesic treatment. The clinical departments in the hospital advocated that Nalbuphine can replace Meperidine, and the notification of short message service for those with large usages was enhanced. Finally, the data on the changes in the usage of Meperidine and Nalbuphine from August 2018 to December 2021 were collected. Overall, the usage of Nalbuphine increased month by month after it was introduced; in contrast, the average monthly usage of Meperidine decreased from 545 in 2018 to 47 in 2021. It was found that a key point of the golden cross appeared for the use of the two drugs one year after Nalbuphine was introduced. In conclusion, Nalbuphine can indeed replace Meperidine to meet the clinical needs for pain relief when it is used in hospitals. In addition, the annual drug purchase cost of Meperidine can be significantly saved to improve the effectiveness of hospital operations, so the non-controlled drug Nalbuphine has the added benefit of drug profit. Finally, it is hoped that other medical institutions can learn and apply these research findings to the management of controlled drugs in the hospital. Keywords: Meperidine, Nalbuphine, patient safety, hospital management.
ANALISIS MANAJEMEN RISIKO TERHADAP PENGGUNAAN E-BANKING (MOBILE BANKING DAN INTERNET BANKING) PADA BANK BNI SYARIAH
Authors: Siregar Hotnaida , Dinia Juharati , Septiani Retno
Published: June 2022

E-banking is an application that launches banks in order to improve operational activities with a variety of financial and non financial transactions. One of the banks that launches Electronic transactions is BNI Syariah bank. E-banking is a twenty-four-hour banking service provided for finance to be able to conduct banking transactions through mobile phones connected to the internet. E-banking at BNI Syariah Bank. As background research because there is an increase in the use of electronic transactions at the time of this pandemic. The ease of use of e-banking can be put aside by some people to reduce, lie and break into savings funds. This research is a literature study conducted by collecting data through the annual report book and BNI Syariah website by reading, recording and managing data so that it gets results. The data collection is done at secondary data sources which are then analyzed by qualitative descriptive methods. The results show that BNI Syariah carries out risk management on the use of electronic transactions by following Bank Indonesia Regulation No. 13/23 / PBI / 2011 concerning the Implementation of Risk Management for Sharia Commercial Banks and Sharia Business Units. In addition, to avoid risk, BNI Syariah provides tips on safe tips, requirements, how to register in accordance with procedures, and also limits transactions in the use of E-banking to avoid fraud, requiring use and problems of use.Keyword: BNI Syariah E-banking
STRATEGI PENETRASI PASAR UNTUK MENINGKATKAN DAYA SAING PERUSAHAAN E-COMMERCE DI INDONESIA
Authors: Putri Zhulaydar Esa , Labibah Nida Khoirun Nahda , Baidlowi Zulfa Fauziah Irsyada , Sari Diah Novita , Asmaranti Kirena Farah , Abiyasa Ilham Akbar
Published: June 2022

This research aims to describe the market penetration strategies used by companies, especially the Indonesian e-commerce industry, to increase their competitiveness. This research occupies a qualitative method toward Indonesia’s e-commerce industry, especially the three dominating companies, such as Shopee, Tokopedia, and Bukalapak. This study uses descriptive research, and our data sources are documents and literature about market penetration strategies conducted by e-commerce industries. The result showed that their strategy to do the market penetration is price adjustment, cooperation, or collaboration, offering some special promos, developing the features and services, and using artists and influencers as brand ambassadors.Keywords: Economy, Strategic Management, Market Penetration, Competitiveness, E-Commerce
ANALISIS STRATEGI BAURAN PEMASARAN TERHADAP PENINGKATAN PELANGGAN PADA LEMBAGA RAFI BIMBEL TANGERANG
Authors: Setyaningsih Fatma
Published: June 2022

This study aims to determine and analyze the effect of product, price, place, promotion, process, physical evidence and people one by one as well.  simultaneously to increase customers at the Rafi Bimbel Institute in Tangerang.  The research sample consisted of 85 parents of students whose children attended tutoring at the Rafi Bimbel Institute, Tangerang.  The data analysis technique used is multiple linear regression analysis, t test, F test and analysis of the coefficient of determination.  The research conducted resulted in the form of multiple linear regression equation Y = 3.032-0.134 X1 +0.007 X2 + 0.142 X3 + 0.338X4 + 0.458 X5 + 0.348 X6 + 0.181 X7 + e.  The t test produces a place and a process that has a significant effect on increasing customers at the Tangerang Rafi Bimbel Institute.  While the t test for price, promotion, product, people and physical evidence shows that there is no significant effect on increasing customers in Rafi Bimbel's Tutoring in Tangerang.  The F test produces product, price, place, promotion, process, physical evidence and people simultaneously have a significant effect on increasing customers in Rafi Bimbel's Tutoring in Tangerang.  Analysis of the coefficient of determination results in the influence of product, price, place, promotion, process, physical evidence and people simultaneously on the increase in customers at Rafi Bimbel's Tutoring in TangerangKeywords: Service Marketing Mix and Customer Improvement
Sexual Function in Breast Cancer Patients: A Review of the Literature
Authors: Castillo Helena , Mension Eduard , Cebrecos Isaac , Anglès Sònia , Castelo-Branco Camil
Published: June 2022

Background: Breast cancer (BC) is the most prevalent cancer among females worldwide. Despite having survival rates beyond 90% in 5 years nowadays, BC has also the highest rates of lost disability-adjusted life years (DALYs) among all cancers. Sexual dysfunction (SD) is one of the most important causes of the problem, affecting between 40–80% of BC survivors. However, SD remains underdiagnosed and undertreated in the clinical practice. Therefore, this review is aimed to evaluate the assessment of SD in Breast Cancer Survivors (BCS) as well as specific causes affecting their sexual function and the potential therapeutic options for these patients. Methods: In December 2021, a search of observational studies evaluating the sexual function in BCS was performed through Ovid Medline, Embase, PubMed, Cochrane register of controlled trials (CCTR), Cochrane database of systematic reviews (CDSR), Cumulative Index to Nursing & Allied Health Literature (CINAHL) and Google scholar to identify potentially relevant publications. Articles that evaluated non-gynecological cancers were excluded, as well as those focusing on the sexuality of men. Results: Despite being such a prevalent entity and given the particularities of how BC affects the sexuality of patients, SD is not usually discussed in the clinical practice in BCS for various reasons, remaining therefore underdiagnosed and undertreated. SD in BC patients has a multifactorial aetiology, including among others, the effect of BC treatments (related to vaginal mucosae, fatigue, and joint pain), the psychological impact of the diagnostic itself and sociocultural influences related to the alteration of the breast. Various strategies have been suggested to treat SD in BC patients, including pharmacological, physical and psychological options. Evidence shows that vaginal moisturizers and psyco-educational therapies focusing on sexual health and couple-based ones improve sexual function; while systemic treatments and general psychological therapy have not demonstrated benefit. Regarding exercise programmes, body image perception has shown to be improved after a one-year strength training program. Conclusions: SD is a multifactorial condition that affects the quality of life of millions of BCS worldwide, severely underdiagnosed and undertreated up to date. A systematic assessment of sexual function in BCS could be useful to diagnose all cases prematurely to give adequate care and prevent its worsening. Specific treatment options for BCS are key potential investigation targets for the near future.
Ginseng Protects ACE2-Transgenic Mice from SARS-CoV-2 Infection
Authors: Seo Sang Heui
Published: June 2022

Background: The pandemic caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is ongoing, and despite massive vaccination campaigns, individuals continue to be infected with new SARS-CoV-2 variants. We studied the effects of ginseng, an immune-enhancing agent, on conferring immunity against SARS-CoV-2 in transgenic mice expressing the SARS-CoV-2 human angiotensin-converting enzyme 2 (ACE2) receptor. Methods: Human ACE2-transgenic (ACE2-tg) mice were fed ginseng extract for 180 days before they were intranasally infected with SARS-CoV-2. The mortality and morbidity were monitored for 10 days. The amount of antiviral interferon in the lung tissues was measured using enzyme-linked immunosorbent assay (ELISA) kits. Results: Thirty percent of the mice fed ginseng extract prior to infection survived, whereas all those that were not fed ginseng extract prior to infection died. Viral titers in the lungs were significantly lower in mice fed ginseng extract than in those not fed ginseng extract. The induction of antiviral interferon-gamma (IFN-γ) was significantly higher in the lungs of mice fed ginseng extract than in those that were not. Conclusions: Our data indicate that a ginseng-containing diet may enhance immunity against SARS-CoV-2 in a mouse model.
COVID-19 and H1N1-09: A Systematic Review of Two Pandemics with a Focus on the Lung at Autopsy
Authors: Bertozzi Giuseppe , Ferrara Michela , Maiese Aniello , Di Fazio Nicola , Delogu Giuseppe , Frati Paola , La Russa Raffaele , Fineschi Vittorio
Published: June 2022

Background: The purpose of this manuscript is to provide a comparative overview of the two global pandemics: the first on June 11th 2009 due to influenza A H1N1 (H1N1-09); the second and current pandemic caused by coronavirus 2019 (COVID-19) on March 11th 2020, focusing on how autopsy can contribute to the definition of cellular pathology, to clinical pathology and, more generally, to public health. Methods: A systematic literature search selection was conducted on PubMed database on June 5, 2021, with this search strategy: (COVID-19) AND (H1N1 influenza) showing 101 results. The following inclusion criteria were selected: English language; published in a scholarly peer-reviewed journal; full-length articles were further elected. To further refine the research was to focus on the type of manuscript: review, systematic review, and meta-analysis. A critical appraisal of the collected studies was conducted, analyzing titles and abstracts, excluding the following topics: treatment, public health measures and perception of the general population or healthcare personnel about their quality of life. According to these procedures, 54 eligible studies were included in the present review. Results: Histopathological findings play a key role in understanding the pathophysiological mechanisms of diseases and, thus possible therapeutic approaches. The evidence on the thrombo-inflammatory mechanism underlying COVID-19 is growing to a much greater magnitude than the diffuse alveolar damage in common with H1N1-09; our study appears to be in line with these results. The prevailing scientific thinking to explain the morbidity and mortality of COVID-19 patients is that it elicits an exuberant immune reaction characterized by dysregulated cytokine production, known as a “cytokine storm”. Conclusions: The histological and immunohistochemical pattern demonstrated similarities and differences between the infectious manifestations of the two pathogens, which justify empirical therapeutic approaches, in the first phase of the COVID-19 pandemic. Therefore, the previous pandemic should have taught us to promote a culture of clinical and forensic autopsies in order to provide timely evidence from integration among autopsy and clinical data for early adopting adequate therapies.
Preliminary Study on the Possibility to Detect Virus Nucleic Acids in Post-Mortem Blood Samples
Authors: Turrina Stefania , Gibellini Davide , Giannini Giacomo , Lagni Anna , Diani Erica , Lotti Virginia , Soldati Giulia , Gibelli Filippo , Raniero Dario , De Leo Domenico
Published: June 2022

Background: In many forensic cases, the medical records of the deceased are not available at the time of the autopsy; therefore, no information about the deceased’s state of health, including any infectious diseases contracted during life, is accessible. The detection of some of the principal viral infections, such as hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus type 1 (HIV-1), could contribute to determining causes of death and interesting applications could be found in medico-legal practice, such as occupational risk assessment. To date, accurate and sensitive serological and molecular assays capable of detecting these viruses have been validated on biological samples taken from living beings, while their efficiency on forensic post-mortem biological samples has yet to be thoroughly assessed. To further this aim, this study evaluated whether the nucleic acid amplification techniques (NAATs) for the detection of viral genomes that are applied in clinical settings can be used, with the same success rate, for these latter samples. Methods: Manual viral nucleic acid extraction processes and fully-automated amplification-based detection techniques developed in-house were evaluated on blood samples taken during the routine autopsies of 21 cadavers performed 2 to 9 days after death. Information on HBV, HCV, and HIV-1 seropositive status was previously known for only four of these cadavers. Results: Using automated quantitative real-time PCR (qPCR) and qualitative PCR (end-point) analyses, it was possible to confirm the presence of viral genomes in the four post-mortem whole blood samples with previously reported specific serological positivity. In addition, the genomes of HCV and/or HIV-1 genomes were detected in three other blood samples with unknown serological status at the time of autopsy. Conclusions: Therefore, our findings suggest that molecular assays may detect the presence of viral genomes in forensic post-mortem blood samples up to five days after death. This provides an additional means of investigation that can contribute to the determination of the deceased’s cause of death.
The state of therapy modalities in clinic for biliary tract cancer
Authors: Chen Weixun , Hu Zhengnan , Song Jia , Wu Yu , Zhang Bixiang , Zhang Lei
Published: June 2022

Biliary tract cancers (BTCs) include intrahepatic cholangiocarcinoma (iCCA), perihilar and distal cholangiocarcinoma (pCCA and dCCA), and gallbladder carcinoma based on the epithelial site of origin. BTCs are highly aggressive tumors associated with poor prognosis due to widespread metastasis and high recurrence. Surgery is the typical curative-intent treatment, yet the cornerstone of cure depends on the anatomical site of the primary tumor, and only a minority of patients (approximately 30%) has an indication necessitating surgery. Similarly, only a small subset of carefully selected patients with early iCCA who are not candidates for liver resection can opt for liver transplantation. Chemotherapy, target therapy, and immunotherapy are the main treatment options for patients who have advanced stage or unresectable disease. The genetic background of each cholangiocarcinoma subtype has been accurately described based on whole gene exome and transcriptome sequencing. Accordingly, precision medicine in targeted therapies has been identified to be aimed at distinct patient subgroups harboring unique molecular alterations. Immunotherapy such as immune checkpoint inhibitors (ICIs) was identified as antitumor responses in a minority of select patients. Current studies indicate that immunotherapy of adoptive cell therapy represents a promising approach in hematological and solid tumor malignancies, yet clinical trials are needed to validate its effectiveness in BTC. Herein, we review the progress of BTC treatment, stratified patients according to the anatomic subtypes of cholangiocarcinoma and the gene drivers of cholangiocarcinoma progression, and compare the efficacy and safety of chemotherapy, targeted therapy, and immunotherapy, which will be conducive to the design of individualized therapies.
Astrocytes Imagined
Authors: Koob Andrew O.
Published: June 2022

The cellular, molecular and physiological basis of cognition has proved elusive until emerging studies on astrocytes. The appearance of a deliberate aggregating element in cellular neurophysiology was difficult to satisfy computationally with excitatory and inhibitory neuron physiology alone. Similarly, the complex behavioral outputs of cognition are challenging to test experimentally. Astrocytic reception and control of synaptic communication has provided the possibility for study of the missing element. The advancement of genetic and neurophysiological techniques have now demonstrated astrocytes respond to neural input and subsequently provide the ability for neural synchronization and assembly at multiple and single synaptic levels. Considering the most recent evidence, it is becoming clear that astrocytes contribute to cognition. Is it possible then that our cognitive experience is essentially the domain of astrocyte physiology, ruminating on neural input, and controlling neural output? Although the molecular and cellular complexities of cognition in the human nervous system cannot be overstated, in order to gain a better understanding of the current evidence, an astrocyte centric basis of cognition will be considered from a philosophical, biological and computational perspective.
Functional MRI Correlates of Stroop N-Back Test Underpin the Diagnosis of Major Depression
Authors: Simeonova Denitsa , Paunova Rositsa , Stoyanova Kristina , Todeva-Radneva Anna , Kandilarova Sevdalina , Stoyanov Drozdstoy
Published: June 2022

Introduction: In the current study, we used the Stroop Color and Word Test (SCWT) combined with an n-back component in functional magnetic resonance imaging (fMRI) in order to activate the working memory and cognitive interference in patients with Major Depressive Disorder (MDD) as compared to healthy controls. Our hypothesis was that there would be significant alterations in the selective visual attention processing regions of the brain which may identify mechanisms underlying major depression. Materials and Methods: Fifty participants, of which 24 were patients with depression and 26 healthy controls were recruited. Results: The first major finding of the current study was hypoactivation in the lingual gyrus during the condition with instructions to track the sequence of the words (word>color) of the Stroop n-back task and hyperactivation of the same structure in the opposite (color>word) condition where subjects had to focus on the order of the word color in depressed patients as compared to healthy controls. Conclusions: Changes in these regions have been consistently reported across studies with different fMRI techniques in both adolescent and adult patients with MDD reinforcing the role of the region in the pathophysiology of depression. Further studies are needed to examine possible longitudinal changes in the region and its activity in remission.
Secondary Prevention after Myocardial Infarction: What to Do and Where to Do It
Authors: Tuka Vladimír , Holub Josef , Bělohlávek Jan
Published: June 2022

Acute myocardial infarction is a manifestation of atherosclerosis which may be fatal. In-hospital and short-term mortality rates after an acute myocardial infarction have declined in the past few decades. However, although long-term mortality has decreased, it remains unacceptably high. This review paper summarises the non-pharmacological interventions (smoking cessation, physical activity, nutrition, and psychosocial intervention) and pharmacological approaches (antiplatelet and lipid-lowering therapy, renin-angiotensin-aldosterone system inhibitors, beta-blockers, and glucose-lowering drugs) to secondary prevention after a myocardial infarction. The provision of secondary prevention services is established through cardiac rehabilitation, which consists of several discussed components. Finally, we discuss the quality indicators for long-term care after an acute myocardial infarction.
Methodology for assessing the extremist potential in social networks
Authors: Baranov Vladimir
Published: June 2022

The article actualizes the problem of the development of extremism with the use of information and communication technologies, comprehends the essence of the assessment of extremist potential in social networks, defines the concepts of extremism, its main types and criteria for assessing extremist behavior in social networks.
Historical background of the origin and development of the institute of public procurement in the Russia
Authors: Ivanov Dmitry , Filatova Irina , Gorach Nikolai , Dolinko Vasily
Published: June 2022

In this article, the authors conclude that in modern conditions of digitalization, the public procurement system has begun to develop actively. On the part of scientists, interest in the designated system is constantly growing, since the public importance of public procurement forces to ensure the effectiveness and safety of procedures. The analysis of the formation and development of the regulatory framework regulating this area allowed the authors to draw a number of conclusions that confirm that today there are gaps and inaccuracies in it that require immediate resolution.
kebijakan fiskal perspektif islam
Authors: Khairunnisa Nur
Published: June 2022

Secara global kebijakan fiskal adalah sebuah kebijakan pemerintah dalam pemungutan pajak dan pembelanjaan pajak, yang dimana kebijakan tersebut untuk membiayai kegiatan ekonomi dan juga kebijakan pemerintah dalam mengatur setiap pendapatan , pengeluaran negara yang digunakan untuk menjaga stabiltas ekonomi.
Sejarah Banjar
Authors: Anggrainisaputri
Published: June 2022

Pendidikanadalahhalyangterpentingdalam pembentukankepribadianberfikir,melaluipendidikanlah pengetahuan,keterampilan,pengalaman,dan wawasandiperolehdanberkembanggunamemperolehilmupengetahuanuntukkebutuhanhidupnyadengantujuanmenjadikaninsanmanusiayangberkualitas.Pendidikanakanterusdibutuhkansejalandengankebutuhanmanusiadalam menjalankanaktivitasdalam segalakehidupan,daripendidikanlahilmuakandiperoleh,denganpendidikanjugaderajatmanusiaakanberkembangkearahyanglebihbaik.Dengandemikian,belajartidakselaluharusdisekolah,lingkungansekitarpunbisadijadikantempatbelajar.TermasukjugasejarahyangbisadijadikansumberbelajaryangberkaitandenganmateriIPSSMP.AktivitasyangterjadidiSEJARAHHABIBKUBAHBASIRIHdigunakansebagaisumberbelajarIPSSMPmulaidaribentukHikmahyangdiambil,AlhabibHamiddikenaldenganwalimajdubatauwaliyangmenyembunyikankewaliannyadenganbertingkahsepertioranggila.Sebagianmenyebutkanwaliyangmempunyaitingkahnyelenehataudiluarkebiasaan.tukarmenukarbarangdenganuang,aktivitaskegiatssehinggapembelajaranakanmejadikontekstual
NILAI-NILAI KEJUANGAN YANG DILAKUKAN PANGERAN HIDAYATULLAH UNTUK TANAH BANJAR
Authors: Fitri Desy Dahrina
Published: June 2022

Sultan Adam menominasikan Pangeran Hidayatullah sebagai Sultan Banjar untuk menggantikan dirinya dan melanjutkan kekuasaan Kesultanan Banjar (Sultan Adam). Dari tahun 1859 hingga 1862, Pangeran Hidayatullah adalah satu-satunya pemimpin rakyat Banjar. Pangeran Hidayatullah juga dikenal menyebarkan agama Islam sebagai ulama. Selama pemerintahan Belanda di Kalimantan, Pangeran Hidayatullah adalah seorang Sultan Banjar yang taat yang terkenal karena penentangannya yang gigih terhadap kolonialisme Belanda. Banyak orang mengidentifikasi Pangeran Hidayatullah karena memiliki karakter patriotik, yaitu cara berpikir, bersikap, dan berbuat yang menunjukkan kesetiaan, kepedulian, dan rasa hormat yang tinggi terhadap tanah airnya, khususnya Banjar. Fakta bahwa nama Pangeran Hidayatullah diabadikan pada sejumlah sarana dan prasarana menggambarkan pentingnya dirinya. Pangeran Hidayatullah lahir di Martapura,1822 dan wafat 24 November 1904 pada umur 82 tahun di Cianjur, Jawa Barat.
Artikel Ritual Babarasih Banua sebagai Upacara Tolak Bala orang kumai
Authors: Husin Amir
Published: June 2022

Hubungan antara agama dan kebudayaan sering menghadirkan sebuah ritual yang menjadi tradisi yang tumbuh dan berkembang didalam masyarakat. Seperti halnya yang ada pada masyarakat Kumai (Bubuhan Kumai) yang berada di Kecamatan Kumai, Kabupaten Kotawaringin Barat, Provinsi Kalimantan Tengah, yang terdapat salah satu ritual, yaitu ritual Babarasih Banua yang berarti membersihkan banua atau kota. Pelaksanaan ritual Babarasih Banua yaitu sebagai upaya menolak bala dan penangkal bencana, bahaya, wabah penyakit, dan musibah yang terjadi di masyarakat Kumai.
Ellena_191012820004_UAS_Artikel_Peran Pedagang Banjar dan Pahlawan Banjar
Authors: ELLENA
Published: June 2022

Perang Banjar disebut De Bandjermasinche Krijg merupakan satu diantara episode penting dalam sejarah pergerakan masyarakat Banjar melawan kolonialisme Belanda. Menurut Gusti Mayur (1979) dalam Zulfa (2017), bagi pemerintah Belanda perang Banjar dianggap perang yang sangat berat karena wilayah yang luas, medan tempur yang sulit, biaya perang cukup banyak sehingga banyak menyebabkan pasukan Belanda tewas dalam peperangan. Banyaknya perwira dan prajurit tantara Belanda yang tewas lebih dari 3.000 orang. Perang Banjar yang mampu membuat pasukan Belanda menjadi terancam hingga kemunduran tidak terlepas dari peran pedagang dan pahlawan perang Banjar. Oleh karena itu, saya sebagai penulis sangat kagum dengan gigihnya pahlawan dalam perang Banjar sehingga dapat menuliskan peran-peran pedagang dan pahlawan perang Banjar.
Stabilitas ekonomi dalam berbagai sistem
Authors: amaliyah zahra
Published: June 2022

Dalam literatur hukum Islam, terdapat beberapa istilah untuk menyebut uang antara lain adalah nuqud, tsaman, fulus, sikkah dan ’umlah. Istilah tsaman memiliki beberapa arti, antara lain berarti qimah, yaitu nilai sesuatu dan harga pembayaran barang yang dijual. Istilah ini digunakan untuk menunjukkan uang emas dan perak. Fulus digunakan untuk pengertian logam bukan emas dan perak yang dibuat dan berlaku di tengah-tengah masyarakat sebagai uang dan pembayaran.
Peristiwa Merah Putih di Sanga-Sanga Kabupaten Kutai Kartanegara Kalimantan Timur
Authors: Wati Naning Yunia
Published: June 2022

Peristiwa Merah Putih yang terjadi di Sanga-Sanga Kalimantan Timur merupakan peristiwakonfrontasi antara tentara BPRI (Barisan Pembela Republik Indonesia) dengan tentara KNIL(Koninklijke Netherlands Indische Leger) Belanda di Sanga-Sanga, Kalimantan Timur padatahun 1947. Peristiwa perjuangan Merah Putih di Sanga-Sanga dilakukan dengan semangat dankerjasama yang dilakukan oleh para pejuang. Tanpa Pernah belajar stategi perang, pejuang MerahPutih dapat menghadapi Belanda. Dengan peralatan dan penguasaan cara bertempur yang sangatterbatas dari pejuang Sanga-Sanga sehingga pada saat itu banyak korban jiwa. Dimata Belanda,para pejuang ini dianggap sebagai ektremis tetapi bagi bangsa Indonesia para pejuang tersebutadalah tokoh pejuang yang memiliki semangat untuk lepas dari belenggu penjajah pada masa itu.Penelitian ini dilakukan dengan studi literatur yang membahas mengenai peristiwa merah putihdi Sanga-Sanga Kabupaten Kutai Kartanegara Kalimantan Timur. Studi pustaka dilakukan untukmengumpulkan data dan informasi yang sesuai, kemudian dilakukan diskusi secara naratif.Peristiwa Merah Putih ini sebagai bentuk protes akan keserakahan penjajah untuk menguasaiwilayah Sanga-Sanga, maka beberapa tokoh pejuang yang ada di Sanga-Sanga ingin berjuanguntuk melawan pasukan penjajah Belanda. Perjuangan itu ditandai dengan keberhasilan BPRImengibarkan bendera Merah Putih di Sanga-Sanga.
Real-world treatment patterns, clinical outcomes, and health care resource utilization in advanced unresectable hepatocellular carcinoma
Authors: O’Sullivan Dylan E , Boyne Devon J , Syed Iqra A , Shephard Cal , Clouthier Derek L , Yoshida Eric M , Spratlin Jennifer L , Batra Atul , Rigo Rodrigo , Hannouf Malek , Yang Hu Xun , Jarada Tamer , Brenner Darren R. , Cheung Winson Y
Published: June 2022

BACKGROUND: The incidence of advanced unresectable hepatocellular carcinoma (HCC) is increasing in developed countries and the prognosis of advanced HCC remains poor. Real-world evidence of treatment patterns and outcomes can highlight the unmet clinical need. METHODS: We conducted a retrospective population-based cohort study of advanced unresectable HCC patients diagnosed in Alberta, Canada (2008–2018) using electronic medical records and administrative claims data. A chart review was conducted on patients treated with systemic therapy to capture additional information related to treatment. RESULTS: A total of 1,297 advanced HCC patients were included of whom 555 (42.8%) were recurrent cases and the remainder were unresectable at diagnosis. Median age at diagnosis was 64 (range 21–94) years and 82.1% were men. Only 274 patients (21.1%) received first-line systemic therapy and of those, 32 patients (11.7%) initiated second-line therapy. Nearly all of the patients received sorafenib (>96.4%) in first-line, and these patients had considerably higher median survival (12.23 months; 95% CI 10.72–14.10) compared with patients not treated with systemic therapy (2.66 months; 95% CI: 2.33–3.12; log-rank p value <0.001). Among patients treated with systemic therapy, overall survival was higher for recurrent cases, patients with Child-Pugh A functional status, and patients with HCV or multiple known HCC risk factors ( p <0.05). CONCLUSIONS: In a Canadian real-world setting, patients who received systemic therapy had greater survival than those who did not, but outcomes were universally poor. These results underscore the need for effective front-line therapeutic options.
É a cibercultura o lugar da (minha) criança? O uso das TICS e a mediação parental na infância
Authors: Miquelão Ribeiro Fernanda , De Almeida Pinto Neide Maria , De Carvalho Fiúza Ana Louise
Published: June 2022

As experiências das crianças são articuladas entre o agir infantil e as expectativas e discursos formulados em torno delas. Essas narrativas podem definir os modos de vida das crianças, causando insegurança e desorientação, sobretudo nas mães e nos pais, quando o assunto envolve as interações dos seus filhos com as tecnologias. A partir dessa temática, este artigo tem como objetivo compreender o papel da mediação parental no uso das Tecnologias de Informação e Comunicação (TICs) por crianças de diferentes contextos sociais na construção das Culturas Infantis. As unidades de observação foram compostas por 57 famílias de crianças pré-escolares, matriculadas em instituições públicas e particulares do Município de Viçosa, MG. Para fins de coleta de dados, as mães, pais e avós das crianças responderam um questionário, com perguntas sobre práticas de uso das TICs pelas crianças e as mediações na família. Os resultados da pesquisa revelaram que as dinâmicas sociais e culturais em torno das interações com as TICs se dão a partir de mediação de controle dos responsáveis, desde a integração das crianças na cibercultura, como também na organização do tempo e dos espaços de educação, lazer e dos seus cotidianos.
A condição de (in)segurança alimentar de estudantes atendidos pelo PNAE do município de Rio Pomba/MG
Authors: Cócaro Henri , De Souza Dias Priscila , Contarini Teodolino Francele , Rodrigo de Paula Assis Thiago
Published: June 2022

O objetivo deste trabalho foi avaliar a condição de (In)Segurança Alimentar e Nutricional de estudantes matriculados no ensino fundamental e médio do município de Rio Pomba/MG cujas escolas acessaram o Programa Nacional de Alimentação Escolar em 2019. Para coleta de dados foram utilizados dois questionários, um referente a Escala Brasileira de Insegurança Alimentar e o outro que abordou 21 variáveis distribuídas em quatro constructos referente a aspectos sociais, econômicos, de acesso a programas e políticas públicas, e também aspectos da alimentação escolar. Por meio de análise estatística descritiva e cruzamento de tabelas, compreendeu-se as associações entre a condição de (in)segurança alimentar e cada um dos constructos concluindo-se que a maioria das famílias, apesar de terem preocupação com a possibilidade de vir a faltar alimentos no futuro próximo, não tinham problema para seu acesso e, portanto, encontrava-se em situação de garantia alimentar tendo o PNAE cumprido papel fundamental para essa condição.
CONDUCTING EDUCATIONAL WEBINARS IN ART INSTITUTIONS OF HIGHER EDUCATION IN THE CONTEXT OF THE COVID-19 PANDEMIC
Authors: Varyvonchyk Anastasiіa , Shvets Irina , Dubovyi Oleksii , Kulik Andriy
Published: June 2022

The purpose of the article is to identify and analyze the forms and means of conducting educational webinars in art institutions of higher education that provide effective professional training in the context of distance learning using web resources, and to explore the significance of educational webinars in modern conditions. The research methodology is based on an interdisciplinary synthesis of scientific methods and approaches integrated from pedagogy and art history; general scientific methods of analysis, synthesis, generalization. The scientific novelty of the article lies in highlighting the advantages and disadvantages of distance learning in the acquisition of value orientations, aesthetic experience and special abilities in the educational process. The article discusses the method of distance learning ‒ a webinar. The perspective of this method as a form of communicative interaction is indicated, which increases the possibilities of creative activity of applicants for education, acquiring a set of performing, professional competencies aimed at the artistic and creative self-realization of the individual in various types of art, in comparison with traditional teaching methods. The main stages of organizing and conducting webinars are outlined. Ways to improve their efficiency are considered. The problems and prospects of using webinars as a model of social interaction between a teacher and a student in the field of distance education are analyzed. The online method of teaching was studied with a focus on achieving a given level of competence and professionalism in mastering information and communication technologies.

Keywords: webinar; distance education; blended learning; information; competencies; online learning; offline learning; computer technology.
COMPARATIVE ANALYSIS OF FLT PROFESSIONAL TRAINING COURSES CONTENT AT UNIVERSITIES IN THE NETHERLANDS AND UKRAINE
Authors: Kolisnichenko Anhelina
Published: June 2022

The article deals with the FLT (foreign language teacher) training program content in the curricula and educational programs. In our study, we aimed to identify the advantages and disadvantages of the FLT training content taken two universities from Ukraine and the Netherlands. The current curricula of Pavlo Tychyna Uman State Pedagogical University and Utrecht University of Applied Sciences were taken for research. The methods of comparison, analysis, generalization and systematization were used to achieve the objectives of the study. The literature review showed the scientific interest in the issue. The lists of subjects in both universities were analysed and summarised that in Ukrainian university curricula there are more subjects of the general and humanitarian cycle, while in the Netherlands’ one they are more specific.In Ukraine, students who have chosen a speciality already have a defined list of major subjects, but also get additional opportunities to study elective ones. In other words, there are no significant differences in the principle of mastering the disciplines, although the list of elective subjects in the Netherlands varies more than in Ukrainian universities. As the results of this study, we defined the advantages and disadvantages of the FLT training program content. In the Netherlands, they are wide academic freedom; academic flexibility in the subject choice; the opportunity to master several specialities; focusing on the study of professional subjects. Ukrainian universities have the following advantages a wide range of subjects; opportunities for parallel learning in related fields; opportunities for choosing optional subjects; effective methodological training (but not in all universities).

Keywords: FLT professional training; the content of pedagogical education; curriculum; professional training cycles; educational program; European educational standards; academic disciplines; higher education applicants.
DEVELOPMENT OF STUDENTS’ COMMUNICATIVE COMPETENCE BY MEANS OF MOBILE APPS
Authors: Komar Oleh
Published: June 2022

The article presents a study of the peculiarities of the communicative competence development of students of the Faculty of Foreign Languages of Pavlo Tychyna Uman State Pedagogical University with an Intermediate level of English language proficiency by means of mobile apps. The aim of the article is to determine the variety of mobile applications that can be used in the process of learning English, and the possibilities of their use to develop students’ communicative competence.The following research questions were formulated in order to develop relevant methodology and expect trustworthy findings: Is the use of mobile apps effective in learning English as a foreign language? What types of mobile apps can be used in the EFL class and autonomous learning? Can the students’ communicative competence be enhanced with the help of mobile apps?The research methodology is based on the use of relevant data collection tools, namely survey and questionnaire with the subsequent experimental intervention, as well as testing.The results of the intervention give indications that mobile apps are becoming an important feature of education as they are an immense step forward and they bring benefits to language learning. The intervention showed that mobile apps can be easily applied in the classroom, arranging group work and creating relevant context for topics under discussion. The learning process can be easily organized only with the smartphones of teacher and students and a steady Internet connection. No other additional devices and previous training are required. Another conclusion comes from the results of pre- and post-tests: students’ communicative competence can be developed and enhanced with the help of properly selected and adequately used mobile apps. It is proved by the slight increase in students’ test results in the experimental group and positive feedback from the students after the action research was completed.

Keywords: English language; communication skills; communicative competence; mobile learning; MALL; mobile app; mobile device; smartphone.
Optimal Trading Portfolio Allocation Enhancement with Maximum Drawdown Using Triple Penance Rule
Authors: Tchoudi William , Sergeenko Grigory
Published: June 2022

This study focuses on optimal portfolio trading allocation, using historic trading data to propose an optimal allocation with risk consideration. The risk factors used sequentially in this study are Sharp Ratio (SR) and Maximum Drawdown (MDD). We use the Sequential Least Squares programming (SLSQP) solver to minimise the negative adapted Sharp Ratio for trading profit and loss (PNL) and then we use the Triple Penance Rule assumption for modelling a mathematical formula to represent the relationship between the MDD and the Time under Water (TUW). In this paper, we introduce the risk measure driven by the MDD as the area of the curve during the TUW. The inverse of this area is used to define a proportional weight to the MDD value. The final weight is obtained by applying an algorithm for removing all MDD outliers in the dataset after SLSQP optimization. The final optimal weight is a combination of the calculated proportional PNL weights and the weights from the MDD area. The benchmark is the equal weight portfolio and the maximal return portfolio from Monte Carlo Simulation (MCS). The tested portfolios are two portfolios made from stocks and securities of the Dow Jones Industrial Average (DOJI) and the NASDAQ Composite (COMP). The initial selection is made from only securities that offer at least five years of historical prices. The results show a good compromise in weight allocation between maximising the PNL and minimising MDD and Sharp ratio.