bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term alterations of collagen reconstruction and basement membrane regeneration after corneal full-thickness penetrating injury in rabbits v1
Authors: Chen Jingjing , Luo Yuqing , Xie Luting , Meng Na , Li Sumei , Xiao Shifang , Li Xia
Published: February 2025

Purpose: To investigate the long-term alterations of collagen reconstruction and basement membrane (BM) regeneration after corneal full-thickness penetrating injury in rabbits. Methods: The corneal full-thickness penetrating injury model was established in the left eye of New Zealand White rabbits using a 2.0 mm trephine. All corneas were evaluated using slit-lamp photography, hematoxylin and eosin staining, mmunofluorescent staining for collagen types I and III (Col I, III), and transmission electron microscopy for collagen fibers and basement membrane. Results: Between 3 days and 3 weeks, Col I and III expression were documented, exhibiting a largely disorganized distribution throughout the stromal thickness. At 3 weeks, the epithelial basement membrane (EBM) partially regenerated. From 3 weeks to 2 months, Col III was undetectable in the anterior stroma but present in the posterior stroma; Col I was disorganized in theposterior stroma. At 2 months, Descemet's membrane (DM) exhibited incomplete regeneration. From 3 to 4 months, Col I was disorganized in only a small part of the posterior stroma; Col III persisted in the posterior stroma; the EBM fully regenerated while DM exhibited incomplete regeneration. Conclusions: Following full-thickness corneal injury, persistent fibrosis within the posterior stroma appears to be primarily responsible for the persistence of corneal scarring. Notably, regeneration of the EBM coincides with remodeling of the anterior stroma, whereas incomplete regeneration of DM is associated with posterior stromal fibrosis.
Conhecimento de profissionais da atenção primária àsaúde sobre toxoplasmose gestacional
Authors: Mizuhira Vanessa , Domingues Wysocki Anneliese , De Paula Andrade Rubia Laine , Brandão Cinara Cássia
Published: February 2025

Introduction: Toxoplasmosis is considered a public health problem because it occurs worldwide and causes complications in immunocompromised individuals and potentially serious consequences with congenital transmission. Objective: to analyze the knowledge of primary healthcare professionals in relation to gestational toxoplasmosis. Methods: This is a cross-sectional study. Data were analyzed using descriptive statistics estimating the prevalence ratio and respective 95% confidence intervals to identify the presence of associated factors. Results: Most primary healthcare professionals have no access to information about toxoplasmosis, have never participated in training, and few provide individual or collective guidance to pregnant women on this subject. Just over half are aware of the need to notify the disease, and a minority know all the transmission routes, diagnostic tests and preventive measures. Conclusions: this survey suggests that professionals lack knowledge about toxoplasmosis and highlights a need for continuing training and discussions, so that the planning of strategies for the prevention and control of gestational toxoplasmosis are constantly improved.
Arthur Purdy Stout: maestro integrador y patólogo de la excelencia
Authors: Lagos Dra. Joan Estefany
Published: February 2025

Sin resumen
BELO HORIZONTE
Authors: Nascimento Luciana Marino do
Published: February 2025

Colocando-se em contraposição os discursos literário e histórico, este trabalho intentou refletir sobre os princípios de ordenamento da cidade e da sociedade, nos fins do século XIX, a partir de uma leitura do romance A Capital, de Avelino Fóscolo.
O TEMA DA VERDADE EM FOE, DE J. M. COETZEE
Authors: Paulo Fernando de Lima
Published: February 2025

Este ensaio pretende estabelecer que Foe, de J. M. Coetzee, ao rejeitar o culto do relativismo fácil, executa um movimento além do ceticismo das práticas ficcionais marcadamente pós-modernas, e elabora estratégias vislumbrando uma posição diferente, na qual a idéia da verdade é examinada.
Representation of Juvenile Delinquency Factors in the Movie "Dua Garis Biru"
Authors: Putr Sekar Amalia , Dwihantoro Prihatin
Published: February 2025

Juvenile delinquency is one of the problems in Indonesia that must receive immediate attention, because the quality of future human resources is in the hands of today's youth. With the sophistication of technology, it should be easier for teenagers to express and learn. Like now, a movie can also be an educational land for its audience. The purpose of this study is to analyze the factors that influence juvenile delinquency in the film Dua Garis Biru. This research uses descriptive qualitative method with content analysis. The results of this study are found two outline factors, namely external and internal factors that represent juvenile delinquency factors. In this study, the analysis method used is the semiotic analysis of Charles Sanders Pierce.
Restrictive Policies on Huawei During the Donald Trump Administration: An Analysis of U.S. National Security and Geopolitical Interests
Authors: Roissyam Anja Yanuar , Nugroho Bambang Wahyu
Published: February 2025

The trade war that occurred between United States and China extended to the technology sector. The two countries are competing in the development of 5G networks. China, through Huawei, which is a pioneer in the development of 5G networks, has faced confrontation from the U.S. government by ban Huawei from operate their business in North America. This article will discuss about the restriction policy on Huawei by the United States of America during Donald Trump's presidency. The United States places restrictions on Huawei based on suspicious that 5G network developed by Huawei can be misused by China government as an espionage tool. This article attempts to analyze the reasons that led to the United States during Donald Trump's presidency imposing restrictive policies on a telecommunications company from China, Huawei. In this article the authors used a qualitative explanatory research method. In analyzing the restriction policy against Huawei, researchers use the concept of national interest and national security concept. Researchers found that the United States placed restrictions on Huawei because the 5G network developed by Huawei might be misused by the Chinese government as and espionage tool against the United States state, companies, and people so that it has the potential to threaten the national security of the United States. Also, through this restriction policy, the United States intends to stem China's hegemony in geopolitical information. Hopefully, this article will provide new insight for future discussion about restriction policy by the United States to Huawei.
Ferdy Sambo Trial News on TvOne-News’s Youtube Account: Critical Discourse Analysis of Police Image in Virtual Public Conversation
Authors: Listiyani Feni , Suryaningtyas Annis Azhar
Published: February 2025

Based on Law No. 2 of 2002, it is stated that the Indonesian Police have four strategic roles: law enforcement, protection, service, and community guidance. Unfortunately, in the past four years, there have been numerous violations committed by unethical police officers. The latest data for the period of January-October 2021 shows 1,694 disciplinary violations, 803 violations of the professional code of ethics and the police ethics commission, and 147 criminal violations. This situation was further exacerbated by the murder of Brigadier Nofriansyah Yosua Hutabarat by former Head of Propam, Inspector General Ferdy Sambo. As a result, the police institution has drawn significant attention from various parties, including the media and the public. The news related to this case became headline news in mass media, including TvOneNews. The television station broadcasted Ferdy Sambo's trial on its YouTube channel, sparking discussions among the virtual public. Based on the explanation, this phenomenon becomes interesting to study in-depth, particularly the discourses constructed by netizens regarding the police institution in the news coverage of the trial of the murder case of Brigadier Nofriansyah Yosua Hutabarat with suspect Inspector General Ferdy Sambo, as broadcasted on the TvOneNews YouTube channel. This research adopts the critical discourse analysis method developed by Teun A. Van Dijk. The data collection technique utilizes documentation from the TvOneNews YouTube account. In conclusion, three discourses can be identified from the coverage of Ferdy Sambo's trial on TvOne. Firstly, TvOne aims to establish the reality of Ferdy Sambo's case by featuring the trial in its breaking news program and broadcasting it live on YouTube. Secondly, there is evidence of abuse of authority and power by senior police officers. Lastly, there are indications of improvements in the legal process in Indonesia, which is exemplified by the transparency of Ferdy Sambo's trial through TvOne's live broadcast.
Routine Recitation Activities Can Improve People’s Religious Behavior
Authors: Zahira Safna Tiara , Aisyah Nurul
Published: February 2025

Routine recitation which is a religious activity as a forum for the implementation of Islamic education for the community, which hopes to produce humans with good religious behavior. The purpose of this study was to determine the relationship between routine recitation and the religious behavior of the people of Sokanandi village, Banjarnegara as well as to analyze their religious behavior. This research uses the methodMixed Methode. Population and research sample taken usingsimple random sampling, namely the Sokanandi village community who attended routine recitation as many as 40 respondents. The research instrument used questionnaires, observations, and interviews. Quantitative data analysis using correlation testproduct moment, While the qualitative data was taken from the results of interviews with five informants consisting of ustadz, as well as regular recitation congregations. The results of the research on the significance of the independent variables, namely routine recitation and the dependent variable, namely the religious behavior of the community, is 0.00 <0.01, which means that H0 is rejected. and it was stated that there was a relationship between routine recitation and the religious behavior of the community and there was an increase in the religious insight of the congregation, so that the jam'ah had better quality religious behavior. It is hoped that with this research, recitation institutions can increase religious activities and recitation facilities, as well as for congregations to remain consistent and be able to invite the surrounding community to attend regular recitations.
Budaya Penggemar di Twitter: Etnografi Virtual pada Penggemar NCT di Twitter
Authors: Sakina Rizqi Aulia , Widyasari Wulan
Published: February 2025

This study aims to analyze NCTzen's online fan culture experience on Twitter. NCTzen is one of the fandoms from the K-pop group called NCT. As fans, NCTzen always tries to get knowledge and information related to NCT. They use Twitter as their medium for doing their activities as fans. NCTzen actively contributed to the development of content media and expanded the scope and impact of text media related to NCT. The method used in this study is a qualitative method with a virtual ethnographic research type. This method uses data collection techniques such as participatory observation, interviews, and documentation. The data analysis technique used is cyber-media analysis. The findings of this study suggest that NCTzen fan culture is a component of participatory culture; it takes shape in affiliation, expressiveness, group problem-solving, and circulation in NCTzen fan activities. Affiliation occurs when NCTzens who carry out their activities online use attributes related to NCT to show themselves as part of the fandom and utilize Twitter features to interact and share with fellow NCTzens. Expression occurs when NCTzens produce creative works whose sources are taken from official NCT content and then shared again through fan accounts in various forms. Such as fan edits, fan works, as well as content and translated texts for NCT content. Collaborative problem-solving is done by working together to support and protect NCT. Such as working together in streaming so that NCT songs enter the charts, voting so that NCT wins awards, and reporting and blocking so that no baseless rumors circulate. The circulation circulating among NCTzens is a thread that informs about matters related to NCT.NCTzen's online fan culture brings together NCTzens from various backgrounds and perspectives so that media content is produced based on the experiences and interpretations of each NCTzen.
Early Middle Adolescents and Quran Memorizers: How Does Social Penetrationn Work?
Authors: Ariibah Fathiyya Khonsa
Published: February 2025

This study describes the process of social penetration of musyrifah (mentor) and female students in an effort to increase memorization at the Miftahunnajah Islamic Boarding School, and determines the factors influence the self-disclosure of female students to musyrifah. Talking about Islamic boarding schools, ideally a female student will be instilled with Islamic values and morals attached to them. The female students who are fostered in Islamic boarding schools are also not free from the label of being able to memorize the Qur'an. The community believes that Islamic boarding schools are the most ideal place to memorize Qur’an. However, the reality is that Islamic boarding schools, which are believed to be the most ideal places to study and memorize the Qur'an, do not guarantee that all students will succeed in memorizing the Qur'an according to the set targets. Through the role of Musyrifah who acts as a companion as well as a role model, it is expected that female students can realize good morals in their lives. This study used Altman and Taylor's theory of social penetration and self-disclosure. The data collection was carried out using qualitative methods with data collection techniques of interviews, observation, and documentation. The research findings show that the social penetration of musyrifah and female students has been stable. This has an important influence in efforts to increase memorization. Meanwhile, the factors that influence self-disclosure of female students to their musyrifah include five important factors, namely, feelings of liking, dyadic effect, personality, topic, and age. This research also results in theoretical and practical implications related to the social penetration of musyrifah and female students in increasing memorization.
Construction of Company Self-Image Through Social Media Instagram in Semiotic Review
Authors: Nuryanti Desi Eka
Published: February 2025

This article aims to analyze Bakpia Tugu Jogja's self-image through Instagram social media. This research is a field research with a qualitative approach. The problem raised by the author is: How is the construction of Bakpia Tugu Jogja's self-image on Instagram social media based on Ferdinand De Saussure's semiotic analysis? The focus of the research is Instagram Bakpia Kukus Tugu Jogja @bakpiatugujogja. The result obtained is that Bakpia Kukud Tugu Jogja has succeeded in building a self-image as food or souvenirs typical of Jogja. Bakpia Kukus Tugu Jogja has also succeeded in building an elegant image of local products.
Tinjauan Hukum Islam Terhadap Batas Usia Minimal Perkawinan Menurut Undang-Undang Perkawinan
Authors: Putri Izzafi Imellya , Lestari Ahdiana Yuni
Published: February 2025

The minimum age of marriage for a man and woman according to Article 7 paragraph (1) of Law No. 16 of 2019 is 19 years. This paper will discuss how Islamic law reviews the minimum age of marriage according to Law No. 16 of 2019 concerning Marriage. The type of research is normative juridical law research using primary, secondary, and tertiary legal materials. The processing of research materials is carried out by examining the approach of theories, concepts, reviewing the relevant laws and regulations or with a statutory approach. The research material was analyzed in a qualitative descriptive manner. The result of his research is that the minimum age limit for marriage in Law No. 16 of 2019, which is 19 years for men and women, is considered mature to meet the age of maturity in accordance with Islamic religious teachings. However, Islamic law provides for marriage requirements when puberty is complete. Maturity does not depend on age but on the ability and ability to carry out marriage. In addition, the comparative analysis of the minimum age limit for marriage according to Islamic law and Law No. 16 of 2019 concerning Marriage is not much different. Because the Marriage Law is based on the Qur'an, further in Islamic law it is regulated in the Compilation of Islamic Law as a complement to the Marriage Law. Thus, the rules in the Marriage Law are acceptable to the community because there are no provisions that violate Islamic law.
Tax Digitalization, Tax Incentives and Smes Taxpayer Compliance: The Moderating Role of Public Trust
Authors: Alifvia Febby Perlica Nur , Kresnawati Etik
Published: February 2025

In 2022 the government is trying to continue to increase the tax ratio. One of which is by maximizing taxpayer compliance, including for Small and Medium Enterprises (SMEs) sector. Fiscal review in 2022 estimated that SMEs in Special Region of Yogyakarta growth has reached an average of 8.45 percent per year with turnover growth reaching 1.37 percent per year. However, the growth in the number of SMEs is not accompanied by greater tax revenues as indicated by the low tax revenues of SMEs. This study examines the effect of tax digitalization and tax incentives on SMEs taxpayer compliance, moderated by public trust. The research data was collected by distributing questionnaires online and offline. Based on 75 respondents which were determined by the purposive sampling method, the results of the SEM-PLS analysis show that tax digitalization and tax incentives have positive effect on SMEs taxpayer compliance as hypothesized. Meanwhile, instead of moderating the two independent variables on SME taxpayer compliance, public trust becomes an important variable that that can improve SME taxpayer compliance. The finding would suggest that local governments can increase the participation of SMEs as a support for local revenue by encouraging tax compliance through tax digitalization and tax incentives as well as public trust.
Analysis of Factors Affecting Human Development Index in the Ex-Resident of Semarang and Surakarta
Authors: Sulistiani Sulistiani , Setiartiti Lilies
Published: February 2025

The HDI achievements in the ex-resident of Semarang and Surakarta show high and stable performance. Even though there are 2 regencies, namely Grobogan and Wonogiri, with HDI achievements that contrast with the cities of Salatiga, Semarang and Surakarta, the HDI in each district/city continues to increase every year.
This research aims to analyze the effect of Minimum Wage, Economic Growth, Government Expenditure on Education and Health on the Human Development Index (HDI) in the Ex-Resident of Semarang and Surakarta, Central Java Province.
The object is in 13 districts/cities in the period 2015-2019. Data were collected from Central Bureau of Statistics (BPS) and Directorate General of Fiscal Balance (DJPK) using panel data regression with random efect as the best model selected.
The result is that the Minimum Wage has a significant positive effect on HDI. Economic Growth has no significant effect on HDI caused most people do not actively contribute to increasing economic growth due to unequal income distribution, so not all levels of society can receive the benefits. Government Expenditure on Education has a significant negative effect on HDI caused the increase in the number of students and school infrastructure has not been matched by the quantity and quality of educators. In addition, education is a long-term investment, so this variable in the research period has not shown a positive impact on HDI. Government Expenditure on Health has no significant effect on HDI caused the increasing population is not accompanied by an increase in health facilities.
Analysis Of Financial Distress with The Altman Z-Score Method in Food Franchise Companies
Authors: Rasyidah Afifah Putri , Safitri Teti Anggita
Published: February 2025

The Covid-19 pandemic that occurred in Indonesia required the government to take steps by imposing policies during the pandemic. Applicable policies such as the enactment ot the large-scale social restriction policy (PSBB), the imposition of restrictions in community activities (PPKM). This gave rise to a phenomenon during the pandemic that occurred in companies, especially food franchises. Phenomenon that occurs such as the closing of food aotlets in transit areas, shopping centers, and there are even companies that take to the streets to sell their products at relatively affordable prices. As a result of this phenomenon, there are many issues circulating that food franchise companies are experiencing financial distress. This study aims to determine whether a food franchise company is experiencing financial distress by analiysis it is using the Altman Z-score method. This study uses a descriptive quantitative approach, the samples used are 3 food franchise companies. Data collection technidues using literature and documentation. The analysis technique was carried out using the altman Z-score method. The calculation result of the Z score using the Altman method state that food franchise companies are in a state of distress and declining income. The result of this study state that food franchise companies are experiencing financial distress and there is a risk of bankruptcy. This reserch is also a warning for companies in improving financial performance in the future, so that bankruptcy does not occur.
Cash Flow Ratio Analysis Before and During The COVID-19
Authors: Taruna Karina Rachmawati , Nindiasar Avininda Dewi
Published: February 2025

Introduction – This study analyzes cash flow ratios before and after the Covid-19 using cash flow ratio analysis for CPO companies listed on the IDX. Efforts to maintain the strategic role of the palm oil commodity as one of the pillars of Indonesia's economic development. Issuers of crude palm oil (CPO) plantations released financial performance in 2020 with unsatisfactory results due to commodity price pressures due to the Covid-19 causing net profit to experience a considerable decline, and even posting losses. The Coronavirus pandemic has significantly impacted the cash flow of companies in Indonesia. Purpose – This study aims to determine whether there are significant differences in the operating cash flow ratio before and after the Covid-19 for CPO companies listed on the IDX. Methodology/Approach - This research was conducted using quantitative methods, and data collection was carried out using secondary data obtained from the company's annual financial reports. The population of this study was companies in the oil palm plantation sector (CPO) that listed on IDX before the covid-19 in 2019 and during the covid-19 in 2020. Findings – The results of this study used a paired sample t-test which showed that there was a significant difference in the current ratio of cash before the pandemic and after the covid-19, namely 1) the ratio of operating cash flow caused by the company's inability to pay current debts by relying only on cash from operations, 2) the ratio of capital expenditures caused by opening new land and financing research, 3) the ratio of total debt caused by the company not being able to pay all debts solely by relying on operating cash, and 4) the ratio of operating cash flow to profit due to the closing of the market in the European Union due to the lockdown. Originality/Value/Implication - This paper is a pioneering initiative in assessing the impact of the COVID-19 on financial health through cash flow analysis based on empirical data.
Awareness and Perception of Muslim Community Towards Islamic Banking in Yogyakarta
Authors: Agustin Annisa Rahmadania , Wiranatakusuma Dimas Bagus , Sobari Indriyani
Published: February 2025

This study was undertaken to explain how the lack of public knowledge of Islamic banking in Indonesia affects the degree of awareness of the Muslim community about Islamic banking. This study's objective is to uncover and evaluate the degree of knowledge and attitudes of the Muslim community about Islamic banking in Yogyakarta, as well as the variables that influence this awareness. This research was conducted using a quantitative method and distributing questionnaires to 30 Muslim communities who live and work in the Yogyakarta area. Using the Likert Scale, participants were also required to indicate their level of agreement with statements on their views and knowledge of Islamic banking's essential principles and features. According to the data, some Yogyakartans are already familiar with the existence of Islamic banks. In contrast, they are unfamiliar with Islamic banking products and services, as well as financing techniques such as Musharakah, Mudharabah, Murabahah, and Ijaraah. Economics, environment, psychology, and religion also have a significant influence in shaping the Muslim community's understanding and attitudes of Islamic banking in Yogyakarta. By looking at the findings, it is advised that Islamic banks should criticize the deficiencies of implementing Islamic values in Islamic banks.
Use Of Mobile-Based Applications in The Services Public Transportation: Route Optimization and Provision of Efficient Services Through Applications (jalankemana)
Authors: Novia Khusnul Febryla , Kurniawati Andhiani , Wiranatakusuma Dimas Bagus
Published: February 2025

Indonesia has a large and growing population. Rapid population growth has led to increased mobility and the need for transportation to fulfill daily activities. Heavy traffic and congestion that often occurs in various cities in Indonesia are problems that affect the mobility and efficiency of public transportation. The purpose of this paper is to analyze the use of mobile-based applications in public transportation services in optimizing routes and providing efficient services through jalankemana applications. The data in the analysis of the use of mobile-based applications in public transportation services in optimizing routes and providing efficient services comes from data taken based on research results. This study used a survey research method, in which data were collected from respondents who were interviewed or filled out a questionnaire. The questionnaire will focus on the urgency related to the need for public transportation in the Yogyakarta area, especially Yogyakarta Muhammadiyah University students. Surveys can be conducted online or through direct interviews with students in Yogyakarta. The results of the study explain Jalankemana is a mobile application that provides information and services to assist users in planning trips using public transportation. JalanKemana can be a useful application for users who frequently use public transportation to plan their trips more efficiently. This app helps users navigate complex transportation systems, provides up-to-date information, and enables user collaboration to update relevant information.
The Importance and Challenges Of The Islamic Management in Organizational Practice
Authors: Zahra Monica Kis Al , Wiranatakusuma Dimas Bagus , Aprizal Anggi
Published: February 2025

For Muslims, Islamic management is an important part of organizational practice. This article aims to identify the importance of involvement of Islamic management and to reveal students’ thought about Islamic management. This study uses a qualitative approach because the researcher wants to obtain deeper answers of each participant. In addition, a semi-structural interview was also conducted by the researcher in order to gather information about the participants’ opinion on Islamic values in organizational practice. The research findings show that Islamic management is impactful in the existence of halal market. However, there some participants who argued that the fact of general management is relatively easier to implement is already a challenge for students to learn Islamic management despite its importance in the organization itself. The expansion of Islamic management knowledge and understanding for students can overcome, there are challenges discussed previously. By looking at findings, it needs the real practical implications and use large scale for further researcher so that they can get more varied data.
Determinants Factor of The Use Of E-Wallets for Students and According to The Islamic Perspective
Authors: Zurly Deby Alicia , Wiranatakusuma Dimas Bagus , Paputungan Alvaizy Dwi Putra
Published: February 2025

One of the best inventions of the 21st century is the electronic wallet (e-wallet) which is an integral part of the electronic payment system. As of today, almost all citizens in Indonesia use e-wallets as a payment method. E-wallet is an application or feature developed to make it easier for users to make payments. The use of e-wallets can be accessed easily via the internet, can have a positive impact and also have a negative impact on the use of electronic money services.The study involved students consisting of a man, as well as a woman with ages varying from 19 to 24 years old. Using a qualitative approach, this study uses in-depth interviews as a data collection technique and also obtains from relevant websites or journals. This research shows that E-wallets have grown very rapidly and are used by various groups, including students as millennials. E-wallets are not only understood as a place to store money electronically, but also as a digital payment system with various features, such as top ups, bill payments, bank card storage, money transfers and withdrawals, etc. Students use e-wallets for various purposes, such as paying for online transportation, buying food/drinks, paying bills, etc. There are several fundamental reasons students use e-wallets as a payment method because of the promos offered, ease of transactions, and ease of operation. In using e-wallets, students not only feel comfortable in shopping, but also the convenience of paying because it can be done anywhere as long as the user is connected to the internet. Various conveniences offered by e-wallets, one of which is the simple appearance of the application that allows many users to understand how to operate it quickly.
Anti-Breast Cancer and Pharmacokinetic Prediction of Isorhamnetin, Glucocapparine Capparisine A And B From Capparis Spinosa
Authors: Amaliyah Alfiah , Hasan Mohammed A.H.M
Published: February 2025

The discovery of new natural anticancer agents is considered a remarkable solution to prevent drug resistance and metastasis in breast cancer patients. The Capparis spinosa plant is widely known for its antioxidant and other therapeutic effects. This study aims to evaluate anti-breast cancer activity targeting Akt1 and HIF1A proteins of several phytochemicals in Capparis spinosa through in silico methods and their pharmacokinetic prediction. This research is an in-silico study involving Bioinformatics (PASS Analysis with STITCH & STRING), Molecular Docking, and pkCSM Analysis. According to bioinformatics methods, AKT1 and HIF1A were obtained as potential protein targets. In molecular docking to AKT1 protein, the docking score obtained for Isorhamnetin, Glucocapparine, Capparisine A, Capparisine B, and Ipatasertib as control were -6.2 kcal/mol, -5.3 kcal/mol, -4.9 kcal/mol, -4.9 kcal/mol, and -6.2 kcal/mol respectively. Meanwhile, the docking score for HIF1A protein for Isorhamnetin, Glucocapparine, Capparisine A, Capparisine B, and 2-methoxy estradiol as control was -5.2 kcal/mol, -4.7 kcal/mol, -4.4 kcal/mol, -4.3 kcal/mol, and -4.7 kcal/mol. The scores for each compound were like the controls in both proteins, indicating that the analyzed phytochemicals of Capparis spinosa have potential anti-breast cancer properties. Pharmacokinetic prediction for absorption, distribution, metabolism, excretion, and toxicity (ADMET) is also provided to help further studies and development for the compounds as anticancer drugs. This study provided data from in silico methods regarding anti-breast cancer supported with pharmacokinetic activities for Isorhamnetin, Glucocapparine Capparisine A, and Capparisine B, which will be helpful as a reference for other advanced research in the future.
Screening the Activity of Epigallocatechin Gallate as a Colorectal Anticancer Agent: In Silico and ADMET/Pharmacokinetic Studies
Authors: Setiadi Prismo Bagas , Alamsyah Maura Shavira , Ningsih Tria , Fajriyah Qatrunada , Febriansah Rifki
Published: February 2025

Introduction - Colorectal cancer is one of the third ranked cancers in Indonesia and has a high level of malignancy. The bioactive compound Epigallocatechin Gallate (EGCG) is known to have antioxidant and cytotoxic activity, so it has the potential to be developed as an anticancer agent. Purpose - This study aims to determine the potential of EGCG compounds as anticancer in silico. Methodology/Approach - The in-silico tests used are molecular docking and ADMET/Pharmacokinetic profiles using biosig pkcsm.Finding - The results of the respective binding affinities formed from EGCG compounds with the target protein affinities of COX-2 and Caspace-3 are -9.2 and -5.4 which are better links between EGCG and Caspace. The Lipinski rule show that the epigallocatecin compound has strength to absorb is 47%. This indicates that EGCG has the potential as a candidate for colorectal anticancer drugs with poor absorption. Originality/Value/Implications – In Silico, many studies have been carried out, but it is still rare to combine molecular docking methods with pKCSM to determine the solubility properties of compounds. The prospect of this research can become a basic or key for developing ECGC compounds into preparations because they have low bioavailability and can be continued in in vitro and in vivo research.
Oral Health-Related Quality of Life (OHRQoL) in Menopausal Medically Compromised Patients at RSGM UMY
Authors: Allifiah Bella Pardian Nur , Triswari Dyah , Hartanti Hartanti
Published: February 2025

Menopause is the time of life when a woman’s ovaries stop producing hormones and the menstrual periods stop. Menopausal women experience a decrease in the function of estrogen and progesterone hormones as a sign of the stopped fertile period for women. Menopause causes hormonal change and systemic conditions for menopausal woman. The systemic condition from hormonal change often makes medically compromised in menopausal woman. These conditions can be related to quality of life-related dental and oral health. This study aims to describe Oral Health-Related Quality of Life (OHRQoL) in menopausal patients with medically compromised at RSGM UMY. This type of research used is descriptive observational with cross-sectional design. 110 participants menopausal women with medically compromised  45 years were given were given the OHIP-14 questionnaire using interview techniques. This study used Oral Health Impact Profile-14 (OHIP-14) questionnaire instruments with frequency data distribution analysis. 40 respondents (36.6%) have good quality of life, 66 respondents (60%) have moderate quality of life, and as many as 4 respondents (3.6%) have poor quality of life. The respondents mayority felt complaints on the physical disturbance dimension of discomfort when chewing. Based on OHIP-14 questionnaire showed that most of the respondents have moderate quality of life (60%).
Peran Generasi Muda Dalam Mendorong Pertanian Berkelanjutan
Authors: Gusya Irsyad M.I , Rozaki Zuhud , Wulandari Retno , Amanah Cantika Wira
Published: February 2025

Empowering the younger generation in agriculture is an urgent need to ensure the sustainability of the sector. The agricultural sector has a strategic role in national economic development, and sustainable agricultural development requires quality human resources. A focus on the younger generation is key to ensuring a strong future for agriculture. Agricultural education needs to be improved, covering vocational to higher-level education, to encourage the participation of the younger generation. Empowerment involves access to quality education, training and field experience. Promotion of sustainable agriculture is important, especially for farmer regeneration. Technological innovation has a big role, with the understanding and application of innovative technologies can increase agricultural productivity. Sustainable agricultural development planning should include economic, environmental and farmer welfare aspects. Innovative agricultural institutions are also key in achieving food security. The involvement of rural youth and the role of young farmers is crucial, with the potential to shift the agricultural paradigm towards more efficient and sustainable practices. Empowering young farmers involves not only technology, but also education, access to capital, and policy support Through the spirit of innovation and collaboration between the government and the private sector, we can create an enabling environment for the development of young farmers as a key pillar in achieving sustainable agriculture, building the foundation for a brighter agricultural future that is responsive to global challenges.
Kunci Kemajuan Pertanian Indonesia: Pandangan Generasi Muda
Authors: Puteri Adinda N. J. , Rozaki Zuhud , Wulandari Retno , Suryani Cahyaningrum A.
Published: February 2025

Agriculture in Indonesia plays an important role in the economy and the welfare of society. This paper reviews the strategic role of the younger generation in developing the agricultural sector. The younger generation brings innovation through the application of modern technology, such as digital equipment and smart farming applications, to improve efficiency and productivity. They also encourage sustainable agricultural practices and organic farming, contributing to national food security as well as protecting the environment. In the context of sustainable development, young people need to receive training and education before entering agriculture, utilising technology and digital resources. Promotions and campaigns that encourage young people to take an active role in modern agriculture are also needed. Government policy support, agricultural technology development, entrepreneurship, preservation of natural resources, inter-sectoral collaboration, export markets, and wise direction of social media are also key measures. The challenges faced by the younger generation include the development of modern farming techniques, so they need to have adequate curiosity and skills. The positive thinking of the younger generation, especially in relation to agriculture, can be a driver for the nation's progress. Therefore, engaging the younger generation wisely in agriculture is key to advancing the sector and improving people's welfare.
Penggunaan Media Sosial Bagi Petani Muda dalam Berwirausaha di Bidang Pertanian
Authors: Kusuma Hanarita Naffi , Rozaki Zuhud , Wulandari Retno , Suryani Cahyaningrum Arie
Published: February 2025

Social media is a platform where everyone can access it, to share moments and information. Nowadays almost everyone has social media for entertainment or to publish something. over time social media is used as a medium to promote products from a business. This is because social media can reach a wider market at a more affordable cost, social media can also be applied to the agricultural sector, especially to educate the younger generation to be more familiar with agriculture and can pursue agriculture, because currently the majority of farmers in Indonesia are more than 40 years old Where, it is very rare to find young people who are involved in agriculture due to lack of education. Even though we can maximise agricultural yields by utilising technology which is currently very sophisticated, various facilities can be obtained but there are still many who think that farming is very difficult and the benefits are not much, we as the next generation of the nation should care about this, we can contribute to the success of agricultural progress in Indonesia by sharing information about agriculture and inviting the public to realise the importance of the agricultural sector so that social media becomes a very important thing to support the progress of agriculture in Indonesia.
Challenges and Opportunities for the Young Generation in Sustainable Agricultural Development
Authors: Priani Gisca Wahyu , Rozaki Zuhud , Wulandari Retno , Azzahra Isni
Published: February 2025

Young people around the world face significant challenges and opportunities in taking a key role in sustainable agricultural development. The growth of the agricultural sector is facing serious challenges, especially with a significant decline in the number of young farmers and an increase in old age farmers. The Journal aims to detail the structural changes of the agricultural workforce with a focus on the phenomenon of peasant aging and the decline of young farmers. In addition, the journal will identify the factors causing such changes and detail the policies needed to support the involvement of young farmers in the agricultural sector. The research methods used include descriptive analysis and data tabulation, with the results of the analysis showing that these challenges are getting worse in Indonesia. Several factors caused the decline in the number of farmers in the agricultural sector, including agricultural modernization, social change, lack of profits, the approach of retirement age. One of the Indonesian government's strategies to overcome the challenges of the younger generation industry is through the development of technology-based startups by providing business incubation facilities. The results of this study show that the lack of young workers in the agricultural sector is due to a lack of interest and confidence in the agricultural sector which is considered less promising for the future. However, young workers in the agricultural sector are needed to maintain and advance food in Indonesia. The crisis of young farmers must be addressed so as not to threaten Indonesia. The crisis of young farmers must be addressed so as not to threaten Indonesia's food security, food security is a strategic aspect, and experience in various countries shows that successful development often depends on previous food security achievements.
Budidaya Jagung Untuk Meningkatkan Hasil
Authors: Safira Adila putri , Rozaki Zuhud , Wulandari Retno , Distrianada Ridho Ikbar
Published: February 2025

Research conducted in Pandes, Wedi Subdistrict, Klaten District, Central Java Province aimed to determine the effect of the number of seeds and pruning on corn yield. The research used a 2 x 4 factorial complete randomized design with two factors, namely the number of corn seeds per planting hole and pruning. The results showed that all treatment parameters did not experience interaction except corn seed weight per cob. The largest seed weight was found in the combination of B1P2 (183.93 grams per cob) while the smallest was found in B1P0 (176.88 grams per cob).
Role of Managers’ Compensation in the Relationship Between Integrated Reporting and Firm Value
Authors: Wardhani Kartika Sukma , Utami Evy Rahman
Published: February 2025

Currently, financial reports alone are considered not to reflect the company's condition, so other information is needed to meet investors' needs. Then, integrated reporting appears, which contains company information, including both financial and non-financial information. Integrated reporting uses integrated information to increase firm value, which attracts investor interest. This research aims to analyse the influence of integrated reporting on firm value, the influence of manager compensation on firm value, and whether manager compensation can moderate the influence of integrated reporting on firm value. The population in this research includes all companies listed on the Indonesia Stock Exchange (BEI) for the 2022 period. The purposive sampling method selects 486 companies that meet the criteria for this research. This reseach relies on descriptive statistics and hypothesis testing. The research results show that integrated reporting does not affect firm value because integrated reporting is considered to require large costs and takes a long time to prepare. The test results in this study also show that manager compensation has no effect on firm value, and manager compensation does not strengthen the relationship between integrated reporting and firm value because the manager's offer makes the manager only fulfil it, not aiming to increase firm value to attract investors.
Políticas públicas e planejamento habitacional sul-coreano
Authors: Pontes Isabela Minucio , Bueno Laura Machado de Mello
Published: February 2025

Este artigo apresenta os resultados de um estudo sobre o Canal Cheonggye em Seul, Coreia do Sul. A partir da revitalização da região, se experimentou um renascimento inovador entre 2003 e 2005, o qual é o objeto foco da dissertação. Inicialmente, buscou-se compreender a história da ocupação de suas margens – assentamentos ​​na década de 1950 e a construção de rodovias na década de 1970. Surpreendeu-nos que não houve a necessidade de remoção de assentados em suas margens no momento da obra, situação comum no Brasil e outros países do Sul Global. Assim. analisamos programas e políticas habitacionais desde a década de 1950, avançando nas políticas atuais no presente artigo, buscando demonstrar a evolução das políticas habitacionais na Coreia do Sul com base em estatísticas e artigos científicos selecionados publicados principalmente a partir de estudos do Korea Institute of Human Settlements. Através da pesquisa procurou-se entender a política habitacional sul-coreana, e suas diferentes formas de provisão como: produção pública, realocação, reurbanização de assentamentos, diferentes tipos de aluguéis sociais e financiamentos, para entender como o déficit habitacional foi substancialmente reduzido. Desde que o problema é muito presente no Brasil, busca-se compreender a dinâmica socioeconômica e a cultura política que possibilitam a aquisição de moradia digna e como se mantém ao longo dos anos.
PRECISAMOS DAR ADEUS AO ACHISMO: O PAPEL DA LINGUÍSTICA NO COMBATE AO NEGACIONISMO
Authors: Sene Marcus Garcia de , Massini-Cagliari Gladis
Published: February 2025

A linguística sempre esteve na linha de frente da crítica das relações de produção capitalista, uma vez que é concebida, junto com as demais ciências humanas e sociais, como não utilitarista (Ordine, 2016). Por não parecer utilitarista, a linguística é alvo de críticas que se iniciam no próprio fazer científico e se estende a visão de língua, que é disseminada como algo monolítico e homogêneo. Sobre este aspecto, vale destacar que o imaginário social é perpassado por uma concepção de homogeneidade linguística (Lucchesi, 2015) e, a partir disso, viabiliza o surgimento de falsos saberes que são veiculados, recorrentemente, em todas as mídias. Sendo assim, o intento deste artigo é discutir o papel da ciência linguística na desmistificação de pseudo-saberes que são responsáveis por endossar a visão do purismo linguístico. Para isso, toma-se como referência à publicação realizada na Folha de São Paulo no dia 02/05/2020 cujo título é “Adeus à linguagem”. É válido destacar que os falsos saberes encontrados na referida publicação acabam sendo prejudiciais para a construção e o desenvolvimento de uma sociedade plural, sem mencionar que reforçam o desconhecimento a respeito de aspectos elementares com os quais os linguistas trabalham cotidianamente: língua, linguagem, léxico e gramática.