bluuebunny/crossref_metadata_2025 huggingface dataset:
Variables Associated with a Urinary MicroRNAs Excretion Profile Indicative of Renal Fibrosis in Fabry Disease Patients
Authors: Jaurretche Sebastián , Perez Germán , Antongiovanni Norberto , Perretta Fernando , Venera Graciela
Published: June 2019

Introduction. In advanced Fabry nephropathy stages, enzyme replacement theraphy (ERT) efficacy decreases, due to its impossibility to reverse renal fibrosis. Therefore, the finding of early kidney fibrosis biomarkers in affected patients is of interest. During renal fibrosis miR-21, miR-192 and miR-433 (fibrosis promotors) are activated by transforming growth factor-β (TGF-β), and miR-29 and miR-200 family (fibrosis supressors) are inhibited by TGF-β. The aim of this study is to analyze the probability that Fabry disease (FD) patients with some clinical variables can present an urinary microRNAs excretion profile indicative of renal fibrosis through a logistic regression analysis. Results. A population of 34 participants was included: 24 FD patients and 10 controls. 16/24 (66.66%) FD patients presented microRNAs urinary excretion profile indicative of renal fibrosis. This profile was observed by decrease of fibrosis suppresors miR-29 and miR-200 and not by increase of fibrosis promotors miR-21, miR192, and miR-433. Hypohidrosis, angiokeratomas, neuropathic pain, hearing loss, cardiac involvement, male gender, reduced αGalA activity, and renin-angiotensin-aldosterone system inhibitors treatment are associated with the appearance of amicroRNAs urinary excretion profile indicative of renal fibrosis. A probable beneficial effect on urinary microRNAs excretion profile was observed in patients receiving ERT with agalsidase beta. The correlation between parameters of renal function with each family of microRNAs was studied. The only association with statistical significance was found between miR-21 and urine albumin-creatinine ratio (p =0.021). Conclusions. A probable microRNAs regulation not mediated by TGF-β should be considered or TGF-β has a different effect in FD than in other nephropathies on microRNAs regulation. Typical clinical manifestations of classic FD are associated with appearance of urinary microRNAs profile indicative of renal fibrosis. FD patients express renal fibrosis biomarkers in urine prior to onset of pathological albuminuria. A direct correlation between urinary miR-21 and degree of albuminuria was observed.
Optical Coherence Tomography Angiography (OCT-A) in a Patient with Occult Retinal Dysfunction
Authors: Wons Juliana , Dinges Jana , Becker Matthias D. , Michels Stephan
Published: June 2019

Multimodal imaging techniques were performed in a patient with a newly emerged visual field defect; a missing retinal lesion on fundus examination made the diagnosis challenging but infrared imaging showed a larger area of retinal abnormality temporal to the fovea. Indocyanine green angiography (IA) showed late hypofluorescence and there was mild hyperautofluorescence which is known from acute zonal occult outer retinopathy (AZOOR). Despite normal fluorescein angiography (FA) results, a perfusion loss in the outer retinal layer was detected by OCT-A. Similar OCT-A findings were recently described in patients with acute macular neuroretinopathy (AMN). Methods. The methods included FA and IA, spectral domain optical coherence tomography (SD-OCT), near infrared imaging, and autofluorescence imaging (AF), as well as OCT-A. Patient. A 36-year-old patient who suffered from acute symptoms of photopsia and scotoma on her left eye. She had an influenza-like illness two weeks earlier. The scotoma could be verified by visual field testing. Results. The affected retinal zone showed mild fading of external limiting membrane (ELM) and a disorganisation of the ellipsoid zone (EZ) on SD-OCT. OCT-A revealed a large area of reduced perfusion in the outer retinal vascular layer. Conclusion. OCT-A can help to detect reduced capillary network in patients with visual field defects and no visible fundus changes. This case seems to have features of different occult retinal disorders such as AZOOR and AMN.
Statin-Associated Necrotizing Autoimmune Myositis Complicated by an Uncommon Adverse Effect to Treatment
Authors: Fung Brian M. , Heinze Emil R. , Wong Andrew L.
Published: June 2019

Statin-associated necrotizing autoimmune myositis (NAM) is an autoimmune condition characterized by severe acute-onset proximal muscle weakness, a very high creatinine kinase (CK) level, and prominent myofiber necrosis and minimal lymphocytic infiltration on muscle biopsy. Unlike self-limited statin myopathy, this condition usually requires aggressive immunomodulation therapy to assist recovery and prevent future disability. In this case report, we present a patient who developed progressive muscle weakness after taking atorvastatin for one year. At initial presentation, her CK level was 28,000 U/L. She was diagnosed with statin-associated NAM and started on high-dose intravenous solumedrol, mycophenolate, and intravenous immunoglobulin (IVIG) therapy. However, she subsequently developed acute bilateral vision loss and right side hemineglect; she was diagnosed with posterior reversible encephalopathy syndrome (PRES), thought to be a possible delayed adverse reaction to IVIG. IVIG was discontinued, and the patient was treated with supportive therapy. At six-month follow-up, she had significant improvement in muscle strength and vision.
Label-Free Imaging of Blood Vessels in Human Normal Breast and Breast Tumor Tissue Using Multiphoton Microscopy
Authors: Xi Gangqin , Cao Ning , Guo Wenhui , Kang Deyong , Chen Zhong , He Jiajia , Ren Wenjiao , Shen Tingfeng , Wang Chuan , Chen Jianxin
Published: June 2019

Blood vessels are the important components of the circulatory systems that transport blood throughout the human body and maintain the homeostasis of physiological tissues. Pathologically, blood vessels are often affected by diseases, leading to the formation of unstable, irregular, and hyperpermeable blood vessels. In the tumor microenvironment, abnormal leakage of tumor blood vessels is related to the histological grade and malignant potential of tumors and may also facilitate metastasis of cancer. Visual diagnosis of blood vessels is very important for us to understand the occurrence and development of diseases. Multiphoton microscopy (MPM) is a potential label-free diagnostic tool based on second harmonic generation (SHG) and two-photon excited fluorescence (TPEF). MPM can effectively observe the morphological changes of biological tissues at the molecular and cellular levels. In this work, we demonstrate that label-free MPM can be used to visualize the microstructure of blood vessels in human normal breast and breast tumor tissue. Moreover, MPM can monitor the changes of blood vessels in tumor microenvironment. These results show that the MPM will become a promising technique for clinicians to study the properties of the microstructure of the blood vessels.
Coordinated Operation of the Constituent Components of a Community Energy System to Maximize Benefits While considering the Network Constraints
Authors: Wijethunge A. H. , Wijayakulasooriya J. V. , Ekanayake J. B. , Polpitiya A.
Published: June 2019

Smart community with locally generated renewable energy is a new paradigm that leads to a system that is more sustainable, secure, and cost-effective to the community while enabling connection of more distributed energy resources. In this paper, a method to maximize the utilization of the renewables while maximizing the profit of a smart community within system constraints was suggested by introducing an optimum schedule of smart appliances in the community. Further dynamic line rating of the network connection is considered to investigate the advantage of using the dynamic rating against static rating. Different operating modes based on the variations of available renewable energy generation, wind speed, tariff, grid curtailment, and user preferences were investigated. A modified genetic algorithm-based optimization was implemented to obtain the optimum smart community’s appliance schedule. The optimum appliance schedules were obtained considering different case studies representing possible operating modes of the system. The simulations show that the use of dynamic line rating and optimum appliance schedule provide higher profit to the community. The algorithm managed to run the optimization with 12,500 controllable entities within an average execution time of 2000s.
Contribution of Ternary Reaction to Pd Sorption on MX-80 in Na-Ca-Cl Solution at High Ionic Strength
Authors: Nagasaki Shinya , Riddoch Justin , Racette Joshua
Published: June 2019

In this study, we first examined the sorption of Pd on MX-80 in Na-Ca-ClO4 solution as a function of pHc (3–9) and ionic strength (0.1 M–4 M) and confirmed that the experimentally derived Kd values could be fitted by a 2-site protolysis nonelectrostatic surface complexation and cation exchange (2SPNE SC/CE) model using three binary surface complexation constants previously estimated. Then, we investigated the sorption of Pd on MX-80 in Na-Ca-Cl-ClO4 solution as a function of pHc (3–9) and Cl-/ClO4- molar concentration ratio (0–∞) at the ionic strength = 4 M. We found that the sorption of Pd on MX-80 in Na-Ca-Cl-ClO4 solution could be simulated only by the three binary and one ternary surface complexations (S-OH+Pd2++4Cl-↔S-OPdCl43-+H+). This suggests that the contribution of other ternary surface complexations such as ≡S-OH +  Pd2++xCl-↔ ≡S-OPdClxx-1-+H+ (x = 1, 2 and 3) to Pd sorption in Na-Ca-Cl-ClO4 solution with ionic strength = 4 M was negligibly small.
Synthesis and Characterization of Nanohydroxyapatite-Gelatin Composite with Streptomycin as Antituberculosis Injectable Bone Substitute
Authors: Hikmawati Dyah , Maulida Hendita N. , Putra Alfian P. , Budiatin Aniek S. , Syahrom Ardiyansyah
Published: June 2019

The most effective treatment for spinal tuberculosis was by eliminating the tuberculosis bacteria and replacing the infected bone with the bone graft to induce the healing process. This study aims to synthesize and characterize nanohydroxyapatite-gelatin-based injectable bone substitute (IBS) with addition of streptomycin. The IBS was synthesized by mixing nanohydroxyapatite and 20 w/v% gelatin with ratio of 40:60, 45:55, 50:50, 55:45, 60:40, 65:35, 70:30, and 75:25 ratio and streptomycin addition as antibiotic agent. The mixture was added by hydroxypropyl methylcellulose as suspending agent. FTIR test showed that there was a chemical reaction occurring in the mixture, between the gelatin and streptomycin. The result of injectability test showed that the highest injectability of the IBS sample was 98.64% with the setting time between 30 minutes and four hours after injection on the HA scaffold that represents the bone cavity and coat the pore scaffold. The cytotoxicity test result showed that the IBS samples were nontoxic towards BHK-21 fibroblast cells and human hepatocyte cells since the viability cell was more than 50% with significant difference (p-value<0.05). The acidity of the IBS was stable and it was sensitive towards Staphylococcus aureus with significantly difference (p-value<0.05). The streptomycin release test showed that the streptomycin could be released from the IBS-injected bone scaffold with release of 2.5% after 4 hours. All the results mentioned showed that IBS was suitable as a candidate to be used in spinal tuberculosis case.
A DFT Analysis on Antioxidant and Antiradical Activities from Anthraquinones Isolated from the Cameroonian Flora
Authors: Ngo Nyobe Judith Caroline , Eyia Andiga Laurent Gael , Mama Désiré Bikele , Ateba Amana Baruch , Zobo Mfomo Joseph , Flavien Aristide Alfred Toze , Ndom Jean Claude
Published: June 2019

The present work is devoted to the exploration antioxidant and antiradical activity of twenty anthraquinones isolated from the Cameroonian flora at B3LYP/6-311++G(d,p) level of theory using the B3LYP/6-31 + G(d,p) geometrical data as geometry optimization starting points. The single electron transfer mechanism has been adopted to examine both biological activities. The classification of the antiradical profile to integrate the electrodonating power (ω−), electroaccepting power (ω+), donor index (Rd) and acceptor index (Ra) has been performed using the donor-acceptor map (DAM). The antioxidant and radical powers of compounds analyzed have been compared to that of two classical vitamins (vitamin C and gallic acid). The stability of each anthraquinone derivative of the molecular library has been developed according to thermodynamic and kinetic concepts. The global reactivity descriptors (GRDs; electrophilicity index (ω), electronegativity (χ), global softness (S), and global hardness (η)) have been used to analyze the reactivity. The topological analysis of optimized structures indicates that the strength of the hydrogen bonds formed is situated between 44.205 and 52.001 kJ/mol. Our B3LYP results reveal that 3-methoxy-1-vismiaquinone (in a configuration without hydrogen bond) exhibits the best antioxidant capacity in gas phase. A comparison between antioxidant performance of molecules examined and that of classical vitamins (gallic acid, caffeic acid, ferulic acid, and ascorbic acid (vitamin C)) displayed the fact that the single electron transfer (SET) mechanism is more prominent for compounds of the molecular library analyzed. In the same vein, the antiradical behaviors of anthraquinone derivatives have shown to be higher than that of gallic acid and vitamin C in gas phase and water. The 5,8-dihydroxy-2-methylantraquinone structure in a configuration bearing one hydrogen bond has been found to be the best antiradical of the series in aqueous solution.
Enhanced Visual Attentional Modulation in Patients with Inherited Peripheral Retinal Degeneration in the Absence of Cortical Degeneration
Authors: Ferreira Sónia , Pereira Andreia Carvalho , Quendera Bruno , Reis Aldina , Silva Eduardo Duarte , Castelo-Branco Miguel
Published: June 2019

The role of attentional mechanisms in peripheral vision loss remains an outstanding question. Our study was aimed at determining the effect of genetically determined peripheral retinal dystrophy caused by Retinitis Pigmentosa (RP) on visual cortical function and tested the recruitment of attentional mechanisms using functional magnetic resonance imaging (fMRI). We included thirteen patients and twenty-two age- and gender-matched controls. We analyzed cortical responses under attentional demands and passive viewing conditions while presenting a visual stimulus covering the central and paracentral visual field. Brain activity was studied in visual areas V1, V2, and V3 as well as in cortical regions of interest corresponding to the preserved and the damaged visual field. The influence of visual field extent and age of disease onset were also investigated. Cortical thickness of visual areas was also measured. We found that cortical visual responses under attentional demands were increased in patients with larger degeneration of visual field, as demonstrated by significant interaction effects between group and task conditions. Moreover, activation during the task condition was increased for patients in two cortical regions of interest corresponding to the preserved and damaged visual field, specifically in patients with severe visual field loss. These findings were observed in the presence of preserved visual cortical structure. We conclude that RP patients have enhanced visual attention recruitment despite their retinal degeneration, while cortical structure and overall response levels remain intact. The unmasking of feedback signals from higher level visual regions involved in attentional processes may explain the increased cortical responses. These findings are relevant for the design of strategies for treating retinal diseases, based on attentional cuing.
Study Insights into Gastrointestinal Cancer through the Gut Microbiota
Authors: Kong Fanli , Cai Yi
Published: June 2019

The gut microbiome in human is recognized as a “microbial organ” for its roles and contributions in regulating the human homeostasis and metabolism. Gastrointestinal (GI) cancers, especially colorectal cancer (CRC), rank as the most common cancer-related deaths worldwide. Evidences have suggested that the disorder of gut microbiota, also named as “dysbiosis,” is related to the development of a variety of diseases such as inflammatory bowel disease (IBD) and the CRC. However, detailed mechanisms between disease and gut microbiota remain largely unknown. This review introduced the correlation between gastrointestinal diseases and the microbiota in human gut from the recent studies, as well as the roles of microbiota in manipulating the CRC and IBDs development, in order to facilitate future studies and to develop novel methods for the precaution, diagnosis, or even cure of gastrointestinal diseases. Additionally, we also elucidated the possibility of probiotics in treatment against CRC.
A Crack between Orthotropic Materials with a Shear Yield Zone at the Crack Tip
Authors: Loboda V. , Gergel I. , Khodanen T. , Mykhail O.
Published: June 2019

A plane problem for a crack between two anisotropic semi‐infinite spaces under remote tensile‐shear loading is considered. In the framework of the assumption that the crack faces are free of stresses an exact analytical solution of the problem is given on basis of the complex potentials approach. This solution possesses oscillating square root singularities in stresses and in the derivatives of the displacement jumps at the crack tips. To remove these singularities a new model founded on the introduction of the shear yield zones at the crack tips is suggested. This model is appropriate for the cases where interface adhesive layer is softer than the surrounding matrixes. Under this assumption the problem is reduced to the nonhomogeneous combined Dirichlet‐Riemann boundary value problem with the conditions at infinity. An exact analytical solution of this problem is presented for the case of a single yield zone. The length of this zone is found from the finiteness of the shear stress at the end point of the zone. Due to such simulation the shear stress becomes finite at any point and the normal stress possesses only square root singularity at the crack tip. Therefore, the conventional stress intensity factor of the normal stress at the crack tip is used. The numerical illustration of the obtained solution is given.
Discovery and Validation of a Serologic Autoantibody Panel for Early Diagnosis of Esophageal Squamous Cell Carcinoma
Authors: Pan Jianbo , Zheng Qing-Zhu , Li Yadong , Yu Li-Li , Wu Qing-Wei , Zheng Jia-Ying , Pan Xiao-Jie , Xie Bao-Song , Wu Yan-An , Qian Jiang , Zhu Heng , Huang Yi
Published: June 2019

Background:

Esophageal squamous cell carcinoma (ESCC) accounts for the highest incidence rate worldwide and is responsible for the fourth leading cause of cancer-related death. Currently, serologic biomarkers for early ESCC diagnosis are needed for timely treatment.

Methods:

The performance of a four-autoantibody panel (i.e., anti-TP53, HRAS, CTAG1A, and NSG1) was evaluated by ELISA for the early diagnosis of ESCC with 569 retrospective serum samples. A training set comprising 129 patients with early-stage ESCC, 130 patients with esophageal benign lesion (EBL), and 150 healthy controls (HC) was used to develop an early ESCC predictive model. Data obtained from an independent validation set were used to evaluate and validate the predictive model to distinguish the early ESCC from the controls (EBL+HC). Finally, a multiplexed assay based on the Luminex xMAP technology platform was developed to enable simultaneous detection of the four-autoantibody panel using the validation set.

Results:

The four-autoantibody panel significantly discriminated early ESCC cases from the controls with 62.8% sensitivity at 88.9% specificity in the training set and with 58.0% sensitivity at 90.0% specificity in the independent validation set. The results of the multiplexed assay using xMAP technology for early ESCC showed a significant correlation with that of the ELISA assays with 66.0% sensitivity at 90.9% specificity.

Conclusions:

A four-autoantibody panel showed good performance for early ESCC diagnosis with ELISA and could be further developed into a multiplex assay using the Luminex xMAP technology.

Impact:

The four-autoantibody panel could be used for serologic screening for early ESCC.
Nivolumab in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: Efficacy and Safety in CheckMate 141 by Prior Cetuximab Use
Authors: Ferris Robert L. , Licitra Lisa , Fayette Jerome , Even Caroline , Blumenschein George , Harrington Kevin J. , Guigay Joel , Vokes Everett E. , Saba Nabil F. , Haddad Robert , Ramkumar Shanmugasundaram , Russell Jeffery , Brossart Peter , Tahara Makoto , Colevas A. Dimitrios , Concha-Benavente Fernando , Lynch Mark , Li Li , Gillison Maura L.
Published: June 2019

Purpose:

Cetuximab, which modulates immune responses, may affect the efficacy of subsequent immunotherapy. Here, we assessed outcomes with nivolumab, by prior cetuximab exposure, in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) who had experienced progression within 6 months of platinum-containing chemotherapy.

Patients and Methods:

In the randomized, open-label, phase III CheckMate 141 trial, patients were randomized 2:1 to nivolumab 3 mg/kg every 2 weeks or investigator's choice (IC) of single-agent chemotherapy, with stratification by prior cetuximab exposure. The primary endpoint was overall survival (OS); additional endpoints were progression-free survival, objective response rate, and safety.

Results:

In patients with prior cetuximab exposure, the median OS was 7.1 months with nivolumab versus 5.1 months with IC (HR, 0.84; 95% CI, 0.62–1.15); OS benefit with nivolumab was maintained across most demographic subgroups. In patients without prior cetuximab exposure, the median OS was 8.2 months with nivolumab versus 4.9 months with IC (HR, 0.52; 95% CI, 0.35–0.77); OS benefit with nivolumab was maintained across patient baseline subgroups including tumor programmed death ligand 1 (PD-L1) expression (<1% or ≥1%). Grade 3–4 treatment-related adverse event rates favored nivolumab versus IC in both subgroups.

Conclusions:

Nivolumab appeared to improve efficacy versus IC regardless of prior cetuximab use, supporting its use in patients with R/M SCCHN with or without prior cetuximab exposure. The reduction in risk of death with nivolumab compared with IC was greater in patients without prior cetuximab exposure versus with prior cetuximab exposure.
Distinguishing Lipedematous Scalp, Lipedematous Alopecia, and Diffuse Alopecia Areata
Authors: Dhurat Rachita S. , Daruwalla Sanober Burzin , Ghate Smita Sunil , Jage Mithali Mahendra , Sharma Aseem
Published: June 2019

Soft, spongy or doughy consistency of the scalp resulting from thickening of the subcutaneous layer is termed as lipedematous scalp (LS). When such soft, boggy scalp is associated with hair loss, where the scalp hair is no longer than a few centimeters, it is referred as lipedematous alopecia (LA). There have been coincidental reports of androgenetic alopecia, psoriasis, mucinosis, and discoid lupus erythematosus with LS. We report a case of LS and alopecia areata whose characteristic histopathological feature showed a “swarm of bees” appearance and thickening of subcutaneous tissue. The diagnosis of alopecia areata was further confirmed by immunohistochemistry staining of the tissue showing CD3+ T-lymphocytes around the bulb. The aim of this case report is to make readers understand that LA and LS are not different diseases and one needs to rule out other causes of alopecia in order to pick up conditions which are essentially reversible and treatable.
Variability in Palliative Care Use after Intracerebral Hemorrhage at US Hospitals: A Multilevel Analysis
Authors: Faigle Roland , Gottesman Rebecca F.
Published: June 2019

Background: Palliative care (PC) is an essential component of comprehensive care of patients with intracerebral hemorrhage (ICH). In the present study, we sought to characterize the variability of PC use after ICH among US hospitals. Methods: ICH admissions from hospitals with at least 12 annual ICH cases were identified in the Nationwide Inpatient Sample between 2008 and 2011. We used multilevel logistic regression modeling to estimate between-hospital variance in PC use. We calculated the intraclass correlation coefficient (ICC), proportional variance change, and median OR after accounting for individual-level and hospital-level covariates. Results: Among 26,791 ICH admissions, 12.5% received PC (95% CI 11.5–13.5). Among the 629 included hospitals, the median rate of PC use was 9.1 (interquartile range 1.5–19.3) per 100 ICH admissions, and 150 (23.9%) hospitals had no recorded PC use. The ICC of the random intercept (null) model was 0.274, suggesting that 27.4% of the overall variability in PC use was due to between-hospital variability. Adding hospital-level covariates to the model accounted for 25.8% of the between-hospital variance observed in the null model, with 74.2% of between-hospital variance remaining unexplained. The median OR of the fully adjusted model was 2.62 (95% CI 2.41–2.89), indicating that a patient moving from 1 hospital to another with a higher intrinsic propensity of PC use had a 2.63-fold median increase in the odds of receiving PC, independent of patient and hospital factors. Conclusions: Substantial variation in PC use after ICH exists among US hospitals. A substantial proportion of this between-hospital variability remains unexplained even after accounting for patient and hospital characteristics.
As cinzas de Beuys em Bellatin e o ritual da lebre morta: articulações do humano e do animal pela linguagem artística
Authors: Jasinski Isabel
Published: June 2019

As vivências da arte contemporânea muitas vezes se produzem em espaços de relação e desvio. Nessa perspectiva, a literatura pode ser lida a partir de múltiplos processos que se contaminam. Este artigo trata dos principais aspectos do livro Lecciones para una liebre muerta de Mario Bellatin e da performance “Como explicar quadros a uma lebre morta” de Joseph Beuys para considerar a concepção de arte que está no substrato dos processos colocados em jogo em ambas obras. A imagem da performance de Beuys em Lecciones para uma liebre muerta é imprevisibilidade que se metamorfoseia, Beuys é vestígio na obra de Bellatin, não é apropriação nem demanda correspondência. Ela aprimora a fissura no interior do conhecimento, se manifesta como “signo secreto” que não objetiva esclarecer por meio da lógica de equivalência. O caráter pedagógico das “lições” não propicia o ensinamento em uma relação hierárquica, porém evidencia um apelo ao aprendizado que a arte propicia enquanto expansão das percepções sensitivas do ser humano.
Ejemplaridades errantes. El celoso extremeño (1613) y Penélope (1959)
Authors: Schardong Rosângela
Published: June 2019

En sus Novelas ejemplares, Cervantes inaugura un género de narrativa de ficción, la novela corta, vertiendo a una nueva configuración los modelos consagrados de la novela y resignificando la estética y el lenguaje canónicos de su tiempo. Dalton Trevisan actualiza e intensifica ese hacer poético en sus Novelas nada ejemplares, reconfigurando los ejemplos errantes de las tradiciones literarias, estéticas y socioculturales. Este artículo trae el estudio comparado de dos cuentos por medio del análisis de su composición como narrativas ejemplares, a partir de algunos rasgos estructurales y del examen de las relaciones de género. En el ámbito de las relaciones humanas, figuradas artísticamente, interesa observar cómo la autoridad masculina y la sumisión femenina se justifican, considerándose los valores en boga cuando las obras fueron publicadas. Es notable que Cervantes y Trevisan representan matrimonios dañosos en ingeniosas tramas que censuran las prácticas culturales de su tiempo.
Reescribiendo la historia de la conquista española: Mitos fundacionales en los Comentarios Reales de los Incas
Authors: Autry Evelyn Saavedra
Published: June 2019

Los Comentarios Reales del Inca Garcilaso de la Vega ofrece una narrativa alterna de la historia del Perú y del imperio incaico antes y durante la conquista. Para justificar su concepto de verdad, Garcilaso emplea herramientas retóricas que le permiten servirse de la escritura española y la oralidad quechua. A partir de la reescritura de historias de los cronistas españoles, las cuales defino como mitos y no fábulas, Garcilaso cuestiona la veracidad de esas crónicas y corrige la historia que proponen sobre el incario. Exploro cómo Garcilaso y su retórica edifican los cimientos de la historia de los Incas, justificándose en la autoridad que le brindan el discurso oral y sus conocimientos de los mitos incaicos. Los Comentarios Reales no serían “la más perfecta síntesis entre historia y ficción” (Arias Carbone), sino una continua negociación entre la autoridad de la historia y una ficción referida como fábula. El proyecto de Garcilaso fue historizar el imaginario incaico y establecer un mito fundacional incaico.
Watset: Local-Global Graph Clustering with Applications in Sense and Frame Induction
Authors: Ustalov Dmitry , Panchenko Alexander , Biemann Chris , Ponzetto Simone Paolo
Published: June 2019

We present a detailed theoretical and computational analysis of the Watset meta-algorithm for fuzzy graph clustering, which has been found to be widely applicable in a variety of domains. This algorithm creates an intermediate representation of the input graph, which reflects the “ambiguity” of its nodes. Then, it uses hard clustering to discover clusters in this “disambiguated” intermediate graph. After outlining the approach and analyzing its computational complexity, we demonstrate that Watset shows competitive results in three applications: unsupervised synset induction from a synonymy graph, unsupervised semantic frame induction from dependency triples, and unsupervised semantic class induction from a distributional thesaurus. Our algorithm is generic and can also be applied to other networks of linguistic data.
Validly published but illegitimate. Correction to and comments on Phytotaxa 373: On Hemionitis atreyu, an invalid and unnecessary name, and on the correct name for that species if placed in Hemionitis (Pteridaceae subfam. Cheilanthoideae)
Authors: MOSYAKIN SERGEI L.
Published: June 2019

An interesting nomenclatural case of Hemionitis atreyu Christenhusz (in Christenhusz et al. 2018: 10) was recently considered and discussed in an earlier issue of Phytotaxa (Mosyakin 2018). That species-rank name was originally proposed as a replacement name (not as a new combination with the earliest available species epithet “acrostica”) because of the existence of a supposedly earlier name, “Hemionitis acrosticha” Noronha (1790: 18; 1827: 78). However, the latter name has never been validly published (see Mosyakin 2018), and thus, if the species earlier known mainly as Cheilanthes acrostica (Balbis 1801: 98) Todaro (1866: 215) or Pteris acrostica Balbis (1801: 98) is placed in Hemionitis Linnaeus (1753: 1077), not a replacement name but a new combination was required. That combination has been validated as Hemionitis acrostica (Balb.) Mosyakin (2018: 165).
Funez, L.A. & Hassemer, G. (2018) Erratum for “Hoehnea grandiflora (Lamiaceae), a rare, critically endangered new species from southern Brazil” Phytotaxa 349 (2): 159–166.
Authors: FUNEZ LUÍS ADRIANO , HASSEMER GUSTAVO
Published: June 2019

N/A
Primulina sichuanensis var. pinnatipartita (Gesneriaceae), a remarkable new variety from Chongqing, China
Authors: KONG HANG-HUI , ZHOU XI-LE , ZHOU BIAO-FENG , WEN FANG , YANG LI-HUA
Published: June 2019

Here, we describe and illustrate Primulina sichuanensis var. pinnatipartita, a new variety from southwestern China. This new variety is primarily distinguished from the type variety, P. sichuanensis var. sichuanensis, by its pinnatipartite leaf blade, a rare character in the genus Primulina. We show the morphological features of this new variety with illustrations and photographs.
Hieracium racemosum subsp. amideii (Asteraceae), a new hawkweed taxon from Montecristo island (Tuscan archipelago, Italy)
Authors: GONNELLI VINCENZO , GOTTSCHLICH GÜNTER , ZOCCOLA ANTONIO
Published: June 2019

A new hawkweed taxon endemic to the insula Montecristo (Tuscan archipelago, Italy), Hieracium racemosum subsp. amideii, is described and illustrated. Information on its distribution, ecology and taxonomic relationship is provided.
Two new peltate-leaved species of Begonia L. (Begoniaceae) from northern Vietnam
Authors: RADBOUCHOOM SIRILAK , CHEN WEN-HONG , GUO SHI-WEI , NGUYEN HIEU QUANG , NGUYEN SINH KHANG , NGUYEN HIEP TIEN , SHUI YU-MIN
Published: June 2019

Two new species in Begonia sect. Coelocentrum, Begonia acutis, and B. remusatifolia, have been discovered in the karst regions of northern Vietnam, one of the richest habitats for Begonia. The differences of the two new species were compared with other peltate-leaved species in China and Vietnam, including B. cavaleriei, B. pulvinifera and B. wangii. According to IUCN Red List categories, B. acutis and B. remusatifolia were assigned to the Critically Endangered (CR) and the Endangered (EN) category, respectively.
A revision of Begonia sect. Petermannia on Sumatra, Indonesia
Authors: GIRMANSYAH DEDEN , SUSILA SUSILA , HUGHES MARK
Published: June 2019

Begonia sect. Petermannia is revised for Sumatra, leading to the recognition of 14 species, nine of which are placed in a molecular phylogeny using nuclear ribosomal ITS data, showing they belong to two clades, intermixed with species from Java and Borneo. One new species is described, B. kemiriensis Girm & M.Hughes, from Gunung Kemiri, Aceh Province.
A new species of Hexabdella (Acari: Bdellidae) from Brazil
Authors: HERNANDES FÁBIO A. , DAUD RODRIGO D. , FERES REINALDO J.F.
Published: June 2019

A new species of the genus Hexabdella Van der Schyff, Theron & Ueckermann, Hexabdella cinquaginta sp.n. is herein described, representing the second species of the family Bdellidae from the neotropical region. It can be distinguished from H. singula by its lobed striae on lateral margins of hysterosoma and by the leg chaetotaxy. A key to species of the genus is presented.
Phylogenetic assessment of ultrastructural and histological characters of teeth in the Anostomoidea, Hemiodontidae and Parodontidae (Teleostei: Ostariophysi: Characiformes)
Authors: SCHARCANSKY ALEXANDRE , LUCENA CARLOS ALBERTO S.
Published: June 2019

The ultrastructure and histology of teeth of members of the order Characiformes, in conjunction with the examination of cleared and stained sections and teeth, revealed characters pertinent to understanding the relationships among the Anostomoidea (Curimatidae, Prochilodontidae, Anostomidae, and Chilodontidae), Hemiodontidae, and Parodontidae. The superimposition of these characters onto cladograms of Characiform phylogeny based on morphological and molecular characters confirmed the monophyly of the Anostomoidea, but resulted in conflicting interpretations concerning the relationships of the Hemiodontidae and Parodontidae.
Plant structure ontology: How should we label plant structures with doubtful or mixed identities?
Authors: KIRCHOFF BRUCE K. , PFEIFER EVELIN , RUTISHAUSER ROLF
Published: June 2019

This paper discusses problems with labelling plant structures in the context of attempts to create a unified Plant Structure Ontology. Special attention is given to structures with mixed, or doubtful identities that are difficult or even impossible to label with a single term. In various vascular plants (and some groups of animals) the structural categories for the description of forms are less distinct than is often supposed. Thus, there are morphological misfits that do not fit exactly into one or the other category and to which it is difficult, or even impossible, to apply a categorical name. After presenting three case studies of intermediate organs and organs whose identity is in doubt, we review five approaches to categorizing plant organs, and evaluate the potential of each to serve as a general reference system for gene annotations. The five approaches are (1) standardized vocabularies, (2) labels based on developmental genetics, (3) continuum morphology, (4) process morphology, (5) character cladograms. While all of these approaches have important domains of applicability, we conclude that process morphology is the one most suited to gene annotation.
Updating the Linnaean Heritage: Names as Tools for Thinking about Animals and Plants (cover)
Authors: MINELLI ALESSANDRO , BONATO LUCIO , FUSCO GIUSEPPE
Published: June 2019

In December 2007, Zootaxa celebrated the tercentenary of the birth of Linnaeus with an important collection of 30 articles published as volume 1668 under the title Linnaeus Tercentenary: Progress in Invertebrate Taxonomy.
Phylogenetic hypotheses, taxa and nomina in zoology
Authors: DUBOIS ALAIN
Published: June 2019

Taxonomic paradigms have changed several times during the history of taxonomy, yet a single nomenclatural system, socalled Linnaean, has remained in force all along. It is theory-free regarding taxonomy as it relies on ostensional allocation of nomina to taxa, rather than on intensional definitions of nomina (e.g., “phylogenetic definitions”). Nomina are not descriptions, definitions or theories but simple labels designating taxa. Both for theoretical and practical reasons, this system should be maintained for the allocation and validity of nomina under a cladistic taxonomic paradigm. Whereas taxa can be cladistically defined by apognoses or cladognoses, nomina should remain attached to taxa through onomatophores, combined in some cases with a Principle of Coordination. Under such a system, the allocation of nomina to taxa is automatic, unambiguous and universal, and nomenclature does not infringe upon taxonomic freedom. However, to avoid misunderstandings and to solve some current problems, the current Code of zoological nomenclature should be improved in several respects. The distinction should be made clear between taxonomic categories, which have biological definitions, and nomenclatural ranks, which do not, as they give only a position in a nomenclatural hierarchy: if used consistently under a cladistic paradigm, they simply allow to express hypotheses about successive branchings and sistertaxa relationships. Taxa referred to a given rank in different groups cannot therefore be considered equivalent by any biological criterion. The nomenclatural rules should cover the whole taxonomic hierarchy, which is currently not the case in zoology. The recent strong increase in the number of higher taxa which results from cladistic analyses may quickly lead to chaos and problems in communication if the nomina of these taxa continue to be based on personal tastes and opinions. There is an urgent need for the zoological Code to cover these nomina with automatic and stringent rules leaving no place to subjective interpretation. Just like for those currently covered by the Code, the status of these nomina should be established in their first publication (nomenclatural founder effect). The Code should be protected against alternative nomenclatural systems by rejecting as unavailable all nomina and nomenclatural acts published without respecting the basic Linnaean system of nomenclatural hierarchy of ranks.
Taxonomical, ecological and zoogeographical studies on anisitsiellid water mites (Acari: Hydrachnidia: Anisitsiellidae Koenike, 1910) from Madagascar
Authors: GOLDSCHMIDT TOM
Published: June 2019

Herein the Malagasy Anisitsiellidae are studied for the first time, resulting in records of 24 species in six genera, of which 23 are new to science. Two genera new to science are described: Sotropalpus gen. nov. with the only species S. manga sp. nov., and Bitabulata gen. nov., with B. kelycoxae sp. nov., B. paoma sp. nov. and B. sagai sp. nov. Two new subgenera, Telotaolana subgen. nov. and Cookonia subgen. nov., and nine new species of Nilotonia Thor, 1905 are described: Nilotonia (Dartiella) ivelany sp. nov., N. (Dartiella) onilahy sp. nov., N. (Dartonia) nifymanana sp. nov., N. (Telotaolana) ankaratra subgen. et sp. nov., N. (Telotaolana) hodivaventy subgen. et sp. nov., N. (Telotaolana) kiraro subgen. et sp. nov., N. (Telotaolana) longipalpis subgen. et sp. nov., N. (Cookonia) anjozorobe subgen. et sp. nov. and N. (Cookonia) avomonina subgen. et sp. nov. Two further species (possibly Nilotonia) were found as deutonymphs only and are therefore described tentatively. Mamersella thienemanni K. Viets, 1929, widely distributed in Southern Asia, was found in Madagascar for the first time; the variability of this species is discussed and the deutonymph described. Eight new species of Platymamersopsis K. Viets, 1914 were found, of which two represent a new subgenus — Platymamersopsis (Lavorona) subgen. nov.: Platymamersopsis (s. str.) angulatus sp. nov., P. loharano sp. nov., P. davecooki sp. nov., P. palustris sp. nov. and P. spinalis sp. nov., Platymamersopsis (Lavorona) pinocchio subgen. et sp. nov. and P. (Lavorona) volovitsy subgen. et sp. nov. Additional descriptions are given of Mamersella tototaensis Cook, 1966, Platymamersopsis agnewi K.O. Viets, 1981, P. chutteri K.O. Viets, 1981, P. nordenskioeldi K. Viets, 1914, P. similis Cook, 1966 and P. vietsi Cook, 1966. The morphological patterns, biogeography, diversity and ecology of the Malagasy Anisitsiellidae — especially the krenobiosis of many species — are discussed.
A revision of Oriental Teloganodidae (Insecta, Ephemeroptera, Ephemerelloidea)
Authors: SARTORI MICHEL , PETERS JANICE G. , HUBBARD MICHAEL D.
Published: June 2019

Based on the examination of the type series of Cloe tristis Hagen, 1858 (type species of the genus Teloganodes Eaton, 1882) and material housed in several institutions, a revision of Oriental Teloganodidae is proposed. A lectotype is designated for Teloganodes tristis (Hagen, 1858) and the genus is redefined. The species T. major Eaton, 1884, is a subjective junior synonym of T. tristis Hagen, 1858 (syn. nov.). The genus Macafertiella Wang, 1996 is a subjective junior synonym of Teloganodes Eaton, 1882 (syn. nov.). A phylogenetic analysis is performed on all available nymphs. Teloganodes is restricted to Sri Lanka and the Western Ghats of India and encompasses the type species and T. dentatus Navás, 1931, T. insignis (Wang & McCafferty, 1996) (comb. nov.), and the following new species: T. tuberculatus sp. nov. (Sri Lanka), T. kodai sp. nov. (India), T. jacobusi sp. nov. (Sri Lanka) and T. hubbardi sp. nov. (Sri Lanka). The type material of T. dentata is redescribed. Species from Southeast Asia are assigned to two new genera. Dudgeodes gen. nov. includes the type species D. pescadori sp. nov. (Philippines) and D. lugens (Navás, 1933) comb. nov. (China), D. hutanis sp. nov. (Borneo), D. stephani sp. nov. (Borneo), D. ulmeri sp. nov. (Java, Sumatra), and D. celebensis sp. nov. (Sulawesi). The genus Derlethina gen. nov. is established for D. eloisae sp. nov. (Borneo). The egg morphology is presented for the first time for the family Teloganodidae. Affinities within the family and between related families are discussed and a key to distinguish all species known at the larval stage is proposed.
What is Baetis rhodani (Pictet, 1843) (Insecta, Ephemeroptera, Baetidae)? Designation of a neotype and redescription of the species from its original area
Authors: GATTOLLIAT JEAN-LUC , SARTORI MICHEL
Published: June 2019

Baetis rhodani (Pictet, 1843) is a widespread species that occurs throughout the West Palaearctic. Recently, several sibling species of the subgenus Rhodobaetis have been described and compared to B. rhodani, clearly prompting the need to reassess the taxonomic concept of B. rhodani. The type material of B. rhodani is unfortunately lost or has been destroyed. In order to provide a necessary standard for comparison, a neotype for B. rhodani is designated based on material collected from the best approximation of the type locality (Geneva, Switzerland). The species is also redescribed at both larval and imaginal stages including the set of characters generally used for species identification within the subgenus Rhodobaetis.
A report on Sipyloidea stigmata Redtenbacher (Diapheromeridae: Necrosciinae) as the first phasmid crop pest in India and its redescription
Authors: PRATHAPAN K. D. , ANITH K. N. , FAIZAL M. H. , LEKHA M. , DHANYA M. K.
Published: June 2019

The order Phasmatodea, the stick and leaf insects, include fewer crop pests than other phytophagous groups of insects. Bedford (1978) reviewed their biology and ecology. Outbreaks of stick insects on economically important plants are known from the USA (Graham, 1937), Fiji and other islands in the South Pacific (O’Connor, 1949; Paine, 1968), Australia (Key, 1991) and China (Hennemann, et. al., 2008). Lit and Eusebio (2008) described Pharnacia magdiwang (Phasmatidae) [a junior synonym of P. ponderosa Stål (Hennemann and Conle, 2008)], a minor pest on mango in the Philippines and listed eight species of stick insects associated with economically important plants. Phasmatodea of the Indian subcontinent are poorly known in spite of the rich diversity and none of them are known to be associated with crop plants.
Two new genera for the Botyodes species complex (Lepidoptera: Pyraloidea: Crambidae)
Authors: SINGH NAVNEET , KIRTI JAGBIR SINGH , SINGH HARSIMRAN , RANJAN RAHUL
Published: June 2019

Two new genera of Spilomelinae, Neobotyodes Singh, Kirti & Singh, gen. nov. (Type species: Botyodes crocopteralis Hampson, 1898) and Caldubotys Singh, Kirti & Singh, gen. nov. (Type species: Botys caldusalis Walker, 1859) are established. Morphological descriptions and diagnoses are provided for both the new genera. Two new combinations Neobotyodes crocopteralis and Caldubotys caldusalis are also established.
Does the genus Dasymutilla Ashmead occur in South America? The new genus Quwitilla, new combinations, and new distribution records from Neotropical velvet ants (Hymenoptera: Mutillidae)
Authors: BARTHOLOMAY PEDRO R. , WILLIAMS KEVIN A. , CAMBRA ROBERTO. A. , OLIVEIRA MÁRCIO L.
Published: June 2019

Nine species of the genus Dasymutilla Ashmead have been recorded from South America. One additional species, D. campogrande Manley & Pitts was erroneously recorded from Mexico but is from Brazil, and another species, D. colorado Cambra, Williams & Quintero was recently discovered in Colombia. Four of these nine Dasymutilla belong to a new genus, Quwitilla Williams, Bartholomay & Cambra, gen. nov., which includes: Q. peruviana (Suárez), comb. nov. (and its newly recognized female D. homochroma Suárez, syn. nov.; Q. bellatrix (Manley & Pitts), comb. nov. (based on female only); and Q. blattoserica (Kohl) comb. nov. (type species, already known from both sexes). Two others are actually synonyms of previously recognized Traumatomutilla André species: Dasymutilla brazilia Manley & Pitts, syn. nov. is a junior synonym of T. oculifera (Smith), and D. campogrande, syn. nov. is a junior synonym of T. inermis (Klug). One species is transferred out of Dasymutilla: Xystromutilla aequatorialis (André), comb. nov. Finally, updates and comments are provided on the distribution of D. araneoides (Smith), D. colorado, D. paradoxa (Gerstaecker), and D. pulchra (Smith), the only four South American species remaining in the genus Dasymutilla.
Studies in Australian Tettigoniidae: Three New Species of Agraeciini From North-eastern Australia Orthoptera: Tettigoniidae; Conocephalinae; Agraeciini
Authors: RENTZ DCF , SU YOU NING
Published: June 2019

Three agraeciine species are described from the north-eastern tropics of coastal Queensland. Two species of Austrosalomona are described. A. destructor sp. nov. is common from the Daintree region to Cairns where it has been seen to destroy orchids and other garden flowers. A. poecila has been found on coastal islands as well as at a few localities on the mainland north of Cairns. It has not been implicated in any destructive activities. Salomona nori sp. nov. is known from Kutini-Payamu (Iron Range) where it has been found living in tree holes. It is a large and formidable species that attracts the attention of tourists. Karyotypes and acoustic information are presented for all three species.