bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Water Supplementation on Cognitive Performances and Mood among Male College Students in Cangzhou, China: Study Protocol of a Randomized Controlled Trial
Authors: Zhang Na , Du Songming , Tang Zhenchuang , Zheng Mengqi , Ma Guansheng
Published: August 2017

Introduction: Water accounts for about 75% of brain mass. Cognitive performances and mood may be impaired by hypohydration and improved by water supplementation. Two surveys conducted in China demonstrated that a large proportion of adults and children drank less fluid than the amounts recommended by the Chinese Nutrition Society. The association between hypohydration and cognitive performance has not been reported in China. The purpose of this study is to explore the effect of water supplementation on cognitive performances and mood among male college students in Cangzhou, China. Methods and Analysis: A randomized controlled trial is designed to test the hypothesis. A total of 68 male college students aged 18–25 years will be recruited and randomly assigned into water-supplementation group (WS group, n = 34) and no water-supplementation group (NW group, n = 34) after an overnight fasting, i.e., without eating foods and drinking fluid for 12 h. The first morning urine will be collected to determine urine osmolality on the water supplementation day. Cognitive performances and mood will be performed before water supplementation by researchers with questionnaire. Subjects in the WS group will drink 400 mL purified water within 5 min, while those in NW group will not drink any fluid. One hour later, urine will be collected and urine osmolality, cognitive performances and mood will be measured again. Mixed model of repeated measures ANOVA will be used to investigate the effect of water supplementation on cognitive performances. The study would provide information about the benefit of water supplementation on cognitive performances. Ethics and Dissemination: The study protocol is reviewed and approved by the Ethical Review Committee of the Chinese Nutrition Society. Ethical approval project identification code is CNS-2015-001. Results will be published according to the CONSORT statement and will be reported in peer-reviewed journals. Trial registration: Chinese clinical trial registry. Identifier: ChiCTR-IOR-15007020. Registry name “The effect of hydration on cognitive performance”.
Genome-Wide Transcriptome Analysis Reveals Conserved and Distinct Molecular Mechanisms of Al Resistance in Buckwheat (Fagopyrum esculentum Moench) Leaves
Authors: Chen Wei , Xu Jia , Jin Jian , Lou He , Fan Wei , Yang Jian
Published: August 2017

Being an Al-accumulating crop, buckwheat detoxifies and tolerates Al not only in roots but also in leaves. While much progress has recently been made toward Al toxicity and resistance mechanisms in roots, little is known about the molecular basis responsible for detoxification and tolerance processes in leaves. Here, we carried out transcriptome analysis of buckwheat leaves in response to Al stress (20 µM, 24 h). We obtained 33,931 unigenes with 26,300 unigenes annotated in the NCBI database, and identified 1063 upregulated and 944 downregulated genes under Al stress. Functional category analysis revealed that genes related to protein translation, processing, degradation and metabolism comprised the biological processes most affected by Al, suggesting that buckwheat leaves maintain flexibility under Al stress by rapidly reprogramming their physiology and metabolism. Analysis of genes related to transcription regulation revealed that a large proportion of chromatin-regulation genes are specifically downregulated by Al stress, whereas transcription factor genes are overwhelmingly upregulated. Furthermore, we identified 78 upregulated and 22 downregulated genes that encode transporters. Intriguingly, only a few genes were overlapped with root Al-regulated transporter genes, which include homologs of AtMATE, ALS1, STAR1, ALS3 and a divalent ion symporter. In addition, we identified a subset of genes involved in development, in which genes associated with flowering regulation were important. Based on these data, it is proposed that buckwheat leaves develop conserved and distinct mechanisms to cope with Al toxicity.
Monitoring and Measuring Autophagy
Authors: Yoshii Saori R. , Mizushima Noboru
Published: August 2017

Autophagy is a cytoplasmic degradation system, which is important for starvation adaptation and cellular quality control. Recent advances in understanding autophagy highlight its importance under physiological and pathological conditions. However, methods for monitoring autophagic activity are complicated and the results are sometimes misinterpreted. Here, we review the methods used to identify autophagic structures, and to measure autophagic flux in cultured cells and animals. We will also describe the existing autophagy reporter mice that are useful for autophagy studies and drug testing. Lastly, we will consider the attempts to monitor autophagy in samples derived from humans.
REP1 Modulates Autophagy and Macropinocytosis to Enhance Cancer Cell Survival
Authors: Choi Jungwon , Kim Hyena , Bae Young Ki , Cheong Heesun
Published: August 2017

Rab escort protein 1 (REP1), a component of the Rab geranyl-geranyltransferase 2 complex, plays a role in Rab protein recruitment in proper vesicles during vesicle trafficking. In addition to having well-known tissue degenerative phenotypes in the REP1 mutant, REP1 is tightly associated with cancer development and contributes to cell growth and survival. However, the functional mechanism of REP1 in cancer progression is largely uninvestigated. Here, we show that REP1 plays a crucial role in regulating mammalian target of rapamycin (mTOR) signaling and its downstream pathways, as well as autophagy and macropinocytosis, which are essential for cancer cell survival during metabolic stresses including starvation. REP1 small interfering RNA (siRNA) treatment downregulates mTORC1 activity in growing media, but blocks autophagosome formation under nutrient-depleted conditions. In contrast to the mild decrease of lysosomal enzyme activity seen in REP1 depletion, in REP1 knockdown the subcellular localization of lysosomes is altered, and localization of REP1 itself is modulated by intracellular nutrient levels and mTOR activity. Furthermore, REP1 depletion increases macro pinocytosis which may be a feedback mechanism to compensate autophagy inhibition. Concomitant treatment with macropinocytosis inhibitor and REP1siRNAresults in more significant cell death than autophagy blockade with REP1 knockdown. Therefore, REP1-mediated autophagy and lysosomal degradation processes act as novel regulatory mechanisms to support cancer cell survival, which can be further investigated as a potential cancer-targeting pathway.
Scalable Interactive Visualization for Connectomics
Authors: Haehn Daniel , Hoffer John , Matejek Brian , Suissa-Peleg Adi , Al-Awami Ali , Kamentsky Lee , Gonda Felix , Meng Eagon , Zhang William , Schalek Richard , Wilson Alyssa , Parag Toufiq , Beyer Johanna , Kaynig Verena , Jones Thouis , Tompkin James , Hadwiger Markus , Lichtman Jeff , Pfister Hanspeter
Published: August 2017

Connectomics has recently begun to image brain tissue at nanometer resolution, which produces petabytes of data. This data must be aligned, labeled, proofread, and formed into graphs, and each step of this process requires visualization for human verification. As such, we present the BUTTERFLY middleware, a scalable platform that can handle massive data for interactive visualization in connectomics. Our platform outputs image and geometry data suitable for hardware-accelerated rendering, and abstracts low-level data wrangling to enable faster development of new visualizations. We demonstrate scalability and extendability with a series of open source Web-based applications for every step of the typical connectomics workflow: data management and storage, informative queries, 2D and 3D visualizations, interactive editing, and graph-based analysis. We report design choices for all developed applications and describe typical scenarios of isolated and combined use in everyday connectomics research. In addition, we measure and optimize rendering throughput—from storage to display—in quantitative experiments. Finally, we share insights, experiences, and recommendations for creating an open source data management and interactive visualization platform for connectomics.
Development of a Bridge Inspection Robot Capable of Traveling on Splicing Parts
Authors: Takada Yogo , Ito Satoshi , Imajo Naoto
Published: August 2017

Several infrastructures, such as bridges and tunnels, require periodic inspection and repair to prevent collapse. There is a strong demand for practical bridge inspection robots to reduce the cost and time associated with the inspection of bridges by an inspector. Bridge inspection robots are expected to pass through obstacles such as bolted splice part and right-angled routes. The aim of this study involved developing a bridge inspection robot that can travel on a right-angle path as well as splicing parts. A two-wheel-drive robot was developed and equipped with two rimless wheels as driving wheels. A neodymium magnet was provided at the tip of each spoke. Non-driving wheels were attached at the rear as a rotatable caster. The robot can turn on the spot to avoid the bolt on the splicing part. Experiments were conducted to check the performance of the robot. The results confirmed that the robot passed through the internal right-angle paths in a laboratory and in an actual environment that corresponds to a box girder of a bridge. It is extremely difficult to manually control a robot on the splicing part. Therefore, a camera and an LED (light emitting diode) were attached to autonomously control the robot. The results indicate that the newly developed robot could run through the splicing part without hitting the nuts.
Improved Color Mapping Methods for Multiband Nighttime Image Fusion
Authors: Hogervorst Maarten , Toet Alexander
Published: August 2017

Previously, we presented two color mapping methods for the application of daytime colors to fused nighttime (e.g., intensified and longwave infrared or thermal (LWIR)) imagery. These mappings not only impart a natural daylight color appearance to multiband nighttime images but also enhance their contrast and the visibility of otherwise obscured details. As a result, it has been shown that these colorizing methods lead to an increased ease of interpretation, better discrimination and identification of materials, faster reaction times and ultimately improved situational awareness. A crucial step in the proposed coloring process is the choice of a suitable color mapping scheme. When both daytime color images and multiband sensor images of the same scene are available, the color mapping can be derived from matching image samples (i.e., by relating color values to sensor output signal intensities in a sample-based approach). When no exact matching reference images are available, the color transformation can be derived from the first-order statistical properties of the reference image and the multiband sensor image. In the current study, we investigated new color fusion schemes that combine the advantages of both methods (i.e., the efficiency and color constancy of the sample-based method with the ability of the statistical method to use the image of a different but somewhat similar scene as a reference image), using the correspondence between multiband sensor values and daytime colors (sample-based method) in a smooth transformation (statistical method). We designed and evaluated three new fusion schemes that focus on (i) a closer match with the daytime luminances; (ii) an improved saliency of hot targets; and (iii) an improved discriminability of materials. We performed both qualitative and quantitative analyses to assess the weak and strong points of all methods.
Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds
Authors: Bondaryk Małgorzata , Staniszewska Monika , Zielińska Paulina , Urbańczyk-Lipkowska Zofia
Published: August 2017

Invasive fungal infections are associated with high mortality rates, despite appropriate antifungal therapy. Limited therapeutic options, resistance development and the high mortality of invasive fungal infections brought about more concern triggering the search for new compounds capable of interfering with fungal viability and virulence. In this context, peptides gained attention as promising candidates for the antimycotics development. Variety of structural and functional characteristics identified for various natural antifungal peptides makes them excellent starting points for design novel drug candidates. Current review provides a brief overview of natural and synthetic antifungal peptides.
Low Friction and High Solid-Solid Contact Ratio—A Contradiction for Laser-Patterned Surfaces?
Authors: Bettscheider Simon , Grützmacher Philipp , Rosenkranz Andreas
Published: August 2017

Recording of Stribeck-like curves is a common way to study the effect of laser-patterned surfaces on the frictional efficiency. However, solely relying on the coefficient of friction when identifying the lubrication regime and the underlying working principles can be misleading. Consequently, a ball-on-disc tribometer was combined with an electrical resistivity circuit to simultaneously measure Stribeck-like curves and solid-solid contact ratios for polished and laser-patterned samples. Line-like surface patterns with different periodicities were produced by direct laser interference patterning on steel substrates (AISI304). The reference shows a Stribeck-like behavior well correlating with the contact ratios. The behavior deviates for high sliding velocities (high contact ratios) due to a loss of lubricant induced by centrifugal forces pulling the lubricant out of the contact zone. In contrast, the solid–solid contact ratio of the laser-patterned samples is around 80% for all sliding velocities. Those values can be explained by higher contact pressures and the structural depth induced by the surface topography which make a full separation of the surfaces unlikely. Despite those high values for the contact ratio, laser-patterning significantly reduces friction, which can be traced back to a reduced real contact area and the ability to store oil in the contact zone.
Preparation of Desirable Porous Cell Structure Polylactide/Wood Flour Composite Foams Assisted by Chain Extender
Authors: Wang Youyong , Song Yongming , Du Jun , Xi Zhenhao , Wang Qingwen
Published: August 2017

Polylactide (PLA)/wood flour composite foam were prepared through a batch foaming process. The effect of the chain extender on the crystallization behavior and dynamic rheological properties of the PLA/wood flour composites were investigated as well as the crystal structure and cell morphology of the composite foams. The incorporation of the chain extender enhanced the complex viscosity and storage modulus of PLA/wood flour composites, indicating the improved melt elasticity. The chain extender also led to a decreased crystallization rate and final crystallinity of PLA/wood flour composites. With an increasing chain extender content, a finer and more uniform cell structure was formed, and the expansion ratio of PLA/wood flour composite foams was much higher than without the chain extender. Compared to the unfoamed composites, the crystallinity of the foamed PLA/wood flour composites was improved and the crystal was loosely packed. However, the new crystalline form was not evident.
Rapid Removal of Zinc(II) from Aqueous Solutions Using a Mesoporous Activated Carbon Prepared from Agricultural Waste
Authors: Zhang Xiaotao , Hao Yinan , Wang Ximing , Chen Zhangjing
Published: August 2017

A low-cost activated carbon (XSBLAC) prepared from Xanthoceras Sorbifolia Bunge hull via chemical activation was investigated to determine its adsorption and desorption properties for zinc(II) ions from aqueous solutions. XSBLAC was characterized based on its N2-adsorption/desorption isotherm, EDX, XRD, SEM and FTIR results. An adsorption study was conducted in a series of experiments to optimize the process variables for zinc(II) removal using XSBLAC. Modeling the adsorption kinetics indicated good agreement between the experimental data and the pseudo-second-order kinetic model. The Langmuir equilibrium isotherm fit the experimental data reasonably well. The calculated enthalpy (ΔH0), entropy (ΔS0) and Gibbs free energy (ΔG0) values revealed the endothermic and spontaneous nature of the adsorption process. HNO3 displayed the best desorption performance. The adsorption mechanism was investigated in detail through FTIR and SEM/EDX spectroscopic analyses. The results suggested that XSBLAC is a potential biosorbent for removing zinc(II) from aqueous solutions.
Analytical Model of Nonlinear Stress-Strain Relation for a Strand Made of Two Materials
Authors: Cho Keunhee , Kim Sung , Cho Jeong-Rae , Park Young-Hwan
Published: August 2017

Unlike conventional steel strands, the smart strand supports strain-measuring function and adopts different materials for its core wire and helical wires. This study intends to analytically derive the nonlinear stress-strain model of this strand made of two materials. The effect of the bending moment and torsional moment of the helical wires on the overall load within the range of geometric shapes shown by actually used strands is verified to be negligible and is thus ignored in order to simplify the analytical model. Moreover, the slight difference between the actual and analytic behaviors, which only appears in the slope varying part in the case of bilinear behavior, such as that of steel, is also ignored. The proposed constitutive model of the smart strand obtained by introducing the experimental stress-strain relation between the carbon fiber reinforced polymer core wire and the helical steel wires is in good agreement with the experimental data. The previous analytical models are applicable only to strands made of a unique linear material, whereas the model proposed in this study is also applicable to strands in which the core wire and the helical wires are made of two different materials, exhibiting nonlinear behavior.
The Preparation of Ag Nanoparticle and Ink Used for Inkjet Printing of Paper Based Conductive Patterns
Authors: Cao Lin , Bai Xiaohe , Lin Zhidan , Zhang Peng , Deng Shuling , Du Xusheng , Li Wei
Published: August 2017

Ag nanoparticles were successfully prepared using a liquid reduction method with a suitable mixture reductant of polyethylene glycol (PEG) and ethylene glycol (EG). OP-10 as a dispersing agent, was used to prepare the conductive Ag ink. Ag nanoparticles with an average particle size of 40 nm were prepared while the ratio of PEG to EG was 1:2. Meanwhile, the Ag particles had a narrow size distribution and great dispersion performance. The effects of paper substrates, sintering temperature, and sintering time on the conductivity of the printed Ag ink pattern were also studied. It was found that Lucky porous high glossy photo paper was a good candidate as the printing substrate. The resistivity of the printed pattern could reach 5.1 × 10−3 Ω·cm after heated at 100 °C for 2 h. Hence, the printed pattern showed good conductivity which led to the LED light being on. Furthermore, the Ag nanoparticle ink could be printed to form any pattern as required that still showed good electrical conductivity after being sintered under low-temperature. This could provide new possibilities for the preparation of flexible electrodes.
Numerical Simulation of Droplets Behavior of Cu-Pb Immiscible Alloys Solidifying under Magnetic Field
Authors: Zhang Lin , Man Tiannan , Huang Minghao , Gao Jianwen , Zuo Xiaowei , Wang Engang
Published: August 2017

A model has been presented for the coarsening of the dispersed phase of liquid-liquid two-phase mixtures in Cu-Pb alloys under the effect of a high magnetic field (HMF). The numerical results show that the evolution of size distribution is the result of several factors and the diffusional growth, the collision-coagulation of the Cu-rich droplets (gravity sedimentation and Marangoni migration), and melt flow also have obvious effects on the movement of droplets and coarsening process. The effect of the HMF in the coarsening process of Cu-Pb alloy is studied in this work both by simulation and experiment. The analysis shows that the HMF leads to a decrease in the melt flow velocity, and can also lead to a decrease in the moving velocity of Cu-rich droplets. The HMF significantly reduces the coarsening rate of droplets as compared by the distribution evolutions. Finally, it is shown that droplet collision and coagulation can be dramatically retarded by the HMF. The results of the simulation are compared with the experiments performed with immiscible Cu-Pb alloys, and the discrepancy between theory and experiment is discussed.
New Marine Antifouling Compounds from the Red Alga Laurencia sp.
Authors: Oguri Yuko , Watanabe Mami , Ishikawa Takafumi , Kamada Takashi , Vairappan Charles , Matsuura Hiroshi , Kaneko Kensuke , Ishii Takahiro , Suzuki Minoru , Yoshimura Erina , Nogata Yasuyuki , Okino Tatsufumi
Published: August 2017

Six new compounds, omaezol, intricatriol, hachijojimallenes A and B, debromoaplysinal, and 11,12-dihydro-3-hydroxyretinol have been isolated from four collections of Laurencia sp. These structures were determined by MS and NMR analyses. Their antifouling activities were evaluated together with eight previously known compounds isolated from the same samples. In particular, omaezol and hachijojimallene A showed potent activities (EC50 = 0.15–0.23 µg/mL) against larvae of the barnacle Amphibalanus amphitrite.
Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials
Authors: Choudhary Alka , Naughton Lynn , Montánchez Itxaso , Dobson Alan , Rai Dilip
Published: August 2017

The marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds.
The Effect of the Sintering Temperature and Addition of Niobium and Vanadium on the Microstructure and Mechanical Properties of Microalloyed PM Steels
Authors: Erden Mehmet
Published: August 2017

In this work, the effect of the sintering temperature on the microstructure and mechanical properties of Nb-V added powder metallurgy (PM) steels was investigated. The microstructure and mechanical properties of the Nb-V added PM microalloyed steel were examined by optical microscopy, scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), optical emission spectrometer (OES), tensile and hardness tests. Results indicated that the optimal sintering temperature was 1350 °C and the addition of 0.1%, 0.15% or 0.2% of Nb-V increases the yield strength (YS), ultimate tensile strength (UTS) and hardness of the PM sintered steels. 0.2 wt % Nb-V added PM steel showed the highest values in yield strength (YS), ultimate tensile strength (UTS) and the highest hardness. Elongation also tends to improve with adding Nb-V content. In addition, Nb-V limited grain growth during austenitization.
Stroke Management: An Emerging Role of Nanotechnology
Authors: Sarmah Deepaneeta , Saraf Jackson , Kaur Harpreet , Pravalika Kanta , Tekade Rakesh , Borah Anupom , Kalia Kiran , Dave Kunjan , Bhattacharya Pallab
Published: August 2017

Stroke is among the leading causes of mortality and morbidity worldwide. Stroke incidences and associated mortality are expected to rise to 23 million and 7.8 million, respectively, by 2030. Further, the aging population, imbalanced lifestyles, and environmental factors continue to shift the rate of stroke incidence, particularly in developing countries. There is an urgent need to develop new therapeutic approaches for treating stroke. Nanotechnology is a growing field, offering an encouraging future prospect for medical research in the management of strokes. The world market for nanotechnology derived products is expected to rise manyfold in the coming decades. Different types of nanomaterials such as perfluorocarbon nanoparticles, iron oxide nanoparticles, gold nanoparticles, polymeric nanoparticles, quantum dots, nanospheres, etc. have been developed for the diagnosis as well as therapy of strokes. Today, nanotechnology has also been integrated with stem cell therapy for treating stroke. However several obstacles remain to be overcome when using such nanomaterials for treating stroke and other neurological diseases.
Experimental Investigation of Biotite-Rich Schist Reacting with B-Bearing Fluids at Upper Crustal Conditions and Correlated Tourmaline Formation
Authors: Orlando Andrea , Ruggieri Giovanni , Chiarantini Laura , Montegrossi Giordano , Rimondi Valentina
Published: August 2017

Fluid–rock interaction experiments between a biotite-rich schist (from Mt. Calamita Formation, Elba Island, Italy) and B-bearing aqueous fluids were carried out at 500–600 °C and 100–130 MPa. The experiments have been carried out in order to reproduce the reaction, which would have produced tourmalinisation of the biotite schist, supposedly by circulation of magmatic fluids issued from leucogranitic dykes. The reacting fluids were either NaCl-free or NaCl-bearing (20 wt %) aqueous solutions, with variable concentration of H3BO3 (0.01–3.2 M). The experimental results show that tourmaline (belonging to the alkali group) crystallise under high-temperature and upper crustal conditions (500–600 °C, 100–130 MPa) when H3BO3 concentration in the system is greater than 1.6 M. The composition of tourmaline is either dravitic (Mg-rich) or schorlitic (Fe-rich), depending if an NaCl-bearing or NaCl-free aqueous solution is used. In the first case, a significant amount of Fe released from biotite dissolution remains in the Cl-rich solution resulting from the experiment. By contrast, when pure water is used, Na/K exchange in feldspars makes Na available for tourmaline crystallisation. The high concentration of Fe in the residual fluid has an important metallogenic implication because it indicates that the interaction between the saline B-rich fluid of magmatic derivation and biotite-rich schists, besides producing tourmalinisation, is capable of mobilising significant amounts of Fe. This process could have produced, in part or totally, the Fe deposits located close to the quartz–tourmaline veins and metasomatic bodies of the Mt. Calamita Formation. Moreover, the super-hot reservoir that likely occurs in the deepest part of the Larderello–Travale geothermal field would also be the site of an extensive reaction between the B-rich fluid and biotite-bearing rocks producing tourmaline. Thus, tourmaline occurrence can be a useful guide during deep drilling toward a super-hot reservoir.
Antimicrobial Properties of Silver Cations Substituted to Faujasite Mineral
Authors: Jędrzejczyk Roman J. , Turnau Katarzyna , Jodłowski Przemysław J. , Chlebda Damian K. , Łojewski Tomasz , Łojewska Joanna
Published: August 2017

A goal of our study was to find an alternative to nano-silver-based antimicrobial materials which would contain active silver immobilized in a solid matrix that prevents its migration into the surrounding environment. In this study, we investigated whether silver cations dispersed in an atomic form and trapped in an ion-exchanged zeolite show comparable antimicrobial activity to silver nanoparticles (NPs). The biocidal active material was prepared from the sodium form of faujasite type zeolite in two steps: (1) exchange with silver cations, (2) removal of the external silver oxide NPs by elution with Na2EDTA solution. The modified biocidal zeolite was then added to paper pulp to obtain sheets. The zeolite paper samples and reference samples containing silver NPs were tested in terms of biocidal activity against an array of fungi and bacteria strains, including Escherichia coli, Serratia marcescens, Bacillus subtilis, Bacillus megaterium, Trichoderma viride, Chaetomium globosum, Aspergillus niger, Cladosporium cladosporioides, and Mortierella alpina. The paper with the modified faujasite additive showed higher or similar antibacterial and antifungal activities towards the majority of tested microbes in comparison with the silver NP-filled paper. A reverse effect was observed for the Mortierella alpina strain.
The Improvement of Skin Whitening of Phenylethyl Resorcinol by Nanostructured Lipid Carriers
Authors: Kim Bo-Sik , Na Young-Guk , Choi Jae-Hwan , Kim Inhye , Lee Eunji , Kim Sung-Yeon , Lee Jae-Young , Cho Cheong-Weon
Published: August 2017

Phenylethyl resorcinol (4-(1-phenylethyl)1,3-benzenediol) (PR) is a new whitening agent that has been found to have the ability to inhibit tyrosinase activity. However, the application of PR is limited by photo instability and poor solubility. PR-loaded nanostructured lipid carriers (PR-NLCs) were prepared by the hot-melted ultrasonic method. Glycerol monostearate and olive oil were selected as the solid lipid and liquid lipid for considering the solubility of PR in liquid lipid and partition coefficient of PR in solid lipid, respectively. The particle size and polydispersity index of PR-NLCs were 57.9 ± 1.3 nm and 0.24 ± 0.01, respectively. The encapsulation efficiency and loading capacity of PR-NLCs were 93.1 ± 4.2% and 8.5 ± 0.4%, respectively. The stability test demonstrated that the incorporation of PR into NLCs conferred excellent physicochemical stability and photo stability for at least three months at 4 °C in the dark and 25 °C under daylight. In vitro release of PR-NLCs revealed a sustained release pattern. Cellular tyrosinase assay showed that PR-NLCs could significantly inhibit tyrosinase activity in melanoma cells, suggesting that NLCs can be used as a biocompatible nanocarrier for the effective delivery of skin whitening agents.
Increases in Alcohol Intakes Are Concurrent with Higher Energy Intakes: Trends in Alcohol Consumption in Australian National Surveys from 1983, 1995 and 2012
Authors: Grech Amanda , Rangan Anna , Allman-Farinelli Margaret
Published: August 2017

This research aimed to provide the first assessment of the contribution of alcohol to Australian adults’ diets over time and determine if people reporting alcohol had higher total dietary energy intakes. Secondary analyses of cross-sectional national nutrition surveys from 1983, 1995, and 2011/12 for adults 18 years (n = 26,675) and over were conducted. Alcoholic beverage intake and diet were assessed using 24-h recalls. The proportion of participants reporting alcohol consumption declined over time and in 1983, 1995, and 2011/12 was 52.0%, 44.2%, and 39.8%, respectively, for men (p < 0.001) and 31.6%, 25.7%, and 25.7%, respectively, for women (p < 0.001). A decline in alcohol intake was seen between 1983 and 2012 for all subpopulations, except for women aged over 45 years, for whom alcohol intake increased. Energy intake was higher for participants reporting alcohol intake and the mean difference (SD) in energy intake for those reporting alcohol versus non-consumers was +1514 kJ (462) for men and +1227 kJ (424) for women. Consistent with apparent consumption data, reported alcohol intake for the total population decreased over time. As those reporting alcohol had much higher energy intakes than non-consumers, promoting alcohol intakes consistent with national recommendations may have important implications for the prevention of obesity, particularly for middle-aged women.
Coffee Consumption and Risk of Biliary Tract Cancers and Liver Cancer: A Dose–Response Meta-Analysis of Prospective Cohort Studies
Authors: Godos Justyna , Micek Agnieszka , Marranzano Marina , Salomone Federico , Rio Daniele , Ray Sumantra
Published: August 2017

Background: A meta-analysis was conducted to summarize the evidence from prospective cohort and case-control studies regarding the association between coffee intake and biliary tract cancer (BTC) and liver cancer risk. Methods: Eligible studies were identified by searches of PubMed and EMBASE databases from the earliest available online indexing year to March 2017. The dose–response relationship was assessed by a restricted cubic spline model and multivariate random-effect meta-regression. A stratified and subgroup analysis by smoking status and hepatitis was performed to identify potential confounding factors. Results: We identified five studies on BTC risk and 13 on liver cancer risk eligible for meta-analysis. A linear dose–response meta-analysis did not show a significant association between coffee consumption and BTC risk. However, there was evidence of inverse correlation between coffee consumption and liver cancer risk. The association was consistent throughout the various potential confounding factors explored including smoking status, hepatitis, etc. Increasing coffee consumption by one cup per day was associated with a 15% reduction in liver cancer risk (RR 0.85; 95% CI 0.82 to 0.88). Conclusions: The findings suggest that increased coffee consumption is associated with decreased risk of liver cancer, but not BTC.
Development and Implementation of a Global Health Elective with a Drug Discovery Game for Pharmacy Students
Authors: Covvey Jordan , Guarascio Anthony , O’Donnell Lauren , Tidgewell Kevin
Published: August 2017

Interest in global health education within the pharmacy curriculum has increased significantly in recent years. However, discussion of different models and methods to evaluate course structures are limited. The overall objective was to (1) describe the structure of our global health elective for pharmacy students, and (2) assess educational outcomes related to perceived/formal knowledge and attitudes associated with global health. Our elective was designed using a competency-centered approach to global health education, incorporating reflection, projects, service and game-learning. In addition to course assessments, a pre-post survey questionnaire assessing attitudes, knowledge perception, formalized knowledge and opinions was utilized. Overall, students demonstrated appropriate performance on course assessments, temporally improving throughout longitudinal projects. The survey demonstrated significant increases in knowledge perception as a result of the course; however, no change in formalized knowledge was evident through the survey assessment. Additionally, the incorporation of game-learning into the course was well received by students. Future iterations of the course will focus on utilization of different assessment methods to meet learning outcomes.
Totally Vacuum-Free Processed Crystalline Silicon Solar Cells over 17.5% Conversion Efficiency
Authors: Uzum Abdullah , Kanda Hiroyuki , Fukui Hidehito , Izumi Taichiro , Harada Tomitaro , Ito Seigo
Published: August 2017

In this work, we introduce a totally vacuum-free cost-efficient crystalline silicon solar cells. Solar cells were fabricated based on low-cost techniques including spin coating, spray pyrolysis, and screen-printing. A best efficiency of 17.51% was achieved by non-vacuum process with a basic structure of  CZ-Si p-type solar cells. Short circuit current density (JSC) and open circuit voltage (VOC) of the best cell were measured as 38.1 mA·cm−2 and 596.2 mV, respectively with fill factor (FF) of 77.1%. Suns-Voc measurements were carried out and the detrimental effect of the series resistance on the performance was revealed. It is concluded that higher efficiencies are achievable by the improvements of the contacts and by utilizing good quality starting wafers.
Selecting Lentil Accessions for Global Selenium Biofortification
Authors: Thavarajah Dil , Abare Alex , Mapa Indika , Coyne Clarice , Thavarajah Pushparajah , Kumar Shiv
Published: August 2017

The biofortification of lentil (Lens culinaris Medikus.) has the potential to provide adequate daily selenium (Se) to human diets. The objectives of this study were to (1) determine how low-dose Se fertilizer application at germination affects seedling biomass, antioxidant activity, and Se uptake of 26 cultivated lentil genotypes; and (2) quantify the seed Se concentration of 191 lentil wild accessions grown in Terbol, Lebanon. A germination study was conducted with two Se treatments [0 (control) and 30 kg of Se/ha] with three replicates. A separate field study was conducted in Lebanon for wild accessions without Se fertilizer. Among cultivated lentil accessions, PI533690 and PI533693 showed >100% biomass increase vs. controls. Se addition significantly increased seedling Se uptake, with the greatest uptake (6.2 µg g−1) by PI320937 and the least uptake (1.1 µg g−1) by W627780. Seed Se concentrations of wild accessions ranged from 0 to 2.5 µg g−1; accessions originating from Syria (0–2.5 µg g−1) and Turkey (0–2.4 µg g−1) had the highest seed Se. Frequency distribution analysis revealed that seed Se for 63% of accessions was between 0.25 and 0.75 µg g−1, and thus a single 50 g serving of lentil has the potential to provide adequate dietary Se (20–60% of daily recommended daily allowance). As such, Se application during plant growth for certain lentil genotypes grown in low Se soils may be a sustainable Se biofortification solution to increase seed Se concentration. Incorporating a diverse panel of lentil wild germplasm into Se biofortification programs will increase genetic diversity for effective genetic mapping for increased lentil seed Se nutrition and plant productivity.
Micellization of Photo-Responsive Block Copolymers
Authors: Grimm Oliver , Wendler Felix , Schacher Felix
Published: August 2017

This review focuses on block copolymers featuring different photo-responsive building blocks and self-assembly of such materials in different selective solvents. We have subdivided the specific examples we selected: (1) according to the wavelength at which the irradiation has to be carried out to achieve photo-response; and (2) according to whether irradiation with light of a suitable wavelength leads to reversible or irreversible changes in material properties (e.g., solubility, charge, or polarity). Exemplarily, an irreversible change could be the photo-cleavage of a nitrobenzyl, pyrenyl or coumarinyl ester, whereas the photo-mediated transition between spiropyran and merocyanin form as well as the isomerization of azobenzenes would represent reversible response to light. The examples presented cover applications including drug delivery (controllable release rates), controlled aggregation/disaggregation, sensing, and the preparation of photochromic hybrid materials.
Octadecylamine-Grafted Graphene Oxide Helps the Dispersion of Carbon Nanotubes in Ethylene Vinyl Acetate
Authors: Jia Li-Chuan , Jiao Zhong-Han , Yan Ding-Xiang , Li Zhong-Ming
Published: August 2017

In this paper, the dispersion of carbon nanotube (CNT) in ethylene vinyl acetate (EVA) is demonstrated to be significantly improved by the addition of octadecylamine (ODA)-grafted graphene oxide (GO) (GO–ODA). Compared to the CNT/EVA composite, the resultant GO–ODA/CNT/EVA (G–CNT/EVA) composite shows simultaneous increases in tensile strength, Young’s modulus and elongation at break. Notably, the elongation at break of the G–CNT/EVA composite still maintains a relatively high value of 1268% at 2.0 wt % CNT content, which is more than 1.6 times higher than that of CNT/EVA composite (783%). This should be attributed to the homogeneous dispersion of CNT as well as the strong interfacial interaction between CNT and EVA originating from the solubilization effect of GO–ODA. Additionally, the G–CNT/EVA composites exhibit superior electrical conductivity at low CNT contents but inferior value at high CNT contents, compared to that for the CNT/EVA composite, which depends on the balance of CNT dispersion and the preservation of insulating GO–ODA. Our strategy provides a new pathway to prepare high performance polymer composites with well-dispersed CNT.
Structural Characterization of Mannoglucan from Dendrobium nobile Lindl and the Neuritogenesis-Induced Effect of Its Acetylated Derivative on PC-12 Cells
Authors: Jin Can , Du Zhenyun , Lin Liyan , Zhou Lishuang , Li Saijuan , Liu Qin , Ding Kan
Published: August 2017

A water-soluble polysaccharide (JCS1) was isolated from the stems of Dendrobium nobile Lindl. JCS1 was structurally characterized using a combination of chemical and spectral analysis, including methylation analysis, partial acid hydrolysis, Fourier-transform infrared (FTIR) spectroscopy, gas chromatography (GC), GC-mass spectrometry (MS), and nuclear magnetic resonance (NMR) spectroscopy. The molecular weight was estimated to be 2.3 × 104 Da using high-performance gel permeation chromatography (HPGPC). The sugar composition analysis indicated it was composed of glucose, mannose, xylose, and arabinose in a 40.2:2.3:1.7:1.0 molar ratio. The structure analysis showed that JCS1 was a mannoglucan with a backbone consisting of (1→4)-linked β-Manp and (1→4)-linked α-Glcp with branches at C-6 of (1→4)-linked α-Glcp residues. The branches were composed of T-α-Glcp, 1,4-α-Xylp, and T-α-Araf. In vitro bioactivity tests revealed that the acetylated derivative of JCS1, YJCS1, induced neuritogenesis of PC-12 cells. These results demonstrate that YJCS1 might be a promising bioactive polysaccharide for development as a drug candidate for the possible prevention and treatment of neurodegeneration diseases.
‘Neither Victim nor Executioner’: Essential Insights from Secularization Theory for the Revitalization of the Russian Orthodox Church in the Contemporary World
Authors: Monge Rico
Published: August 2017

This essay explores two recent expressions of hostility towards secularization by Russian Orthodox officials (one from the Holy Synod of ROCOR and the other from Metropolitan Archbishop Hilarion Alfeyev), and evaluates the likely consequences of this hostility. Drawing from secularization theorists including Peter Berger, Jose Casanova, and Charles Taylor, as well as the thought of Albert Camus, this essay argues that the long-term health of the Russian Orthodox Church will benefit from embracing insights from secularization theorists rather than attempting to “desecularize” Russian society with state support.
Existence and Uniqueness for the Multivariate Discrete Terminal Wealth Relative
Authors: Hermes Andreas , Maier-Paape Stanislaus
Published: August 2017

In this paper, the multivariate fractional trading ansatz of money management from Vince (Vince 1990) is discussed. In particular, we prove existence and uniqueness of an “optimal f” of the respective optimization problem under reasonable assumptions on the trade return matrix. This result generalizes a similar result for the univariate fractional trading ansatz. Furthermore, our result guarantees that the multivariate optimal f solutions can always be found numerically by steepest ascent methods.
Monitoring Rainfall Patterns in the Southern Amazon with PERSIANN-CDR Data: Long-Term Characteristics and Trends
Authors: Arvor Damien , Funatsu Beatriz , Michot Véronique , Dubreuil Vincent
Published: August 2017

Satellite-derived estimates of precipitation are essential to compensate for missing rainfall measurements in regions where the homogeneous and continuous monitoring of rainfall remains challenging due to low density rain gauge networks. The Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks—Climate Data Record (PERSIANN-CDR) is a relatively new product (released in 2013) but that contains data since 1983, thus enabling long-term rainfall analysis. In this work, we used three decades (1983–2014) of PERSIANN-CDR daily rainfall data to characterize precipitation patterns in the southern part of the Amazon basin, which has been drastically impacted in recent decades by anthropogenic activities that exacerbate the spatio-temporal variability of rainfall regimes. We computed metrics for the rainy season (onset date, demise date and duration) on a pixel-to-pixel basis for each year in the time series. We identified significant trends toward a shortening of the rainy season in the southern Amazon, mainly linked to earlier demise dates. This work thus contributes to monitoring possible signs of climate change in the region and to assessing uncertainties in rainfall trends and their potential impacts on human activities and natural ecosystems.
Satellite Survey of Internal Waves in the Black and Caspian Seas
Authors: Lavrova Olga , Mityagina Marina
Published: August 2017

The paper discusses the results of a study of short-period internal waves (IWs) in the Black and Caspian Seas from their surface manifestations in satellite imagery. Since tides are negligible in these seas, they can be considered non-tidal. Consequently, the main generation mechanism of IWs in the ocean—interaction of barotropic tides with bathymetry—is irrelevant. A statistically significant survey of IW occurrences in various regions of the two seas is presented. Detailed maps of spatial distribution of surface manifestations of internal waves (SMIWs) are compiled. Factors facilitating generation of IWs are determined, and a comprehensive discussion of IW generation mechanisms is presented. In the eastern and western coastal zones of the Black Sea, where large rivers disembogue, intrusions of fresh water create hydrological fronts that are able to generate IWs. At the continental shelf edge, on the west and northwest of the Black Sea and near the Crimean Peninsula, IWs are generated primarily due to relaxation of coastal upwelling and inertial oscillations associated with hydrological fronts. In addition, IWs can be formed at sea fronts associated with the passage of cold eddies. In the Caspian Sea, seiches are the main source of the observed IWs.
Transformation from a Single Antenna to a Series Array Using Push/Pull Origami
Authors: Shah Syed , Lim Sungjoon
Published: August 2017

We propose a push/pull origami antenna, transformable between a single antenna element and a three-element array. In limited space, the proposed origami antenna can work as a single antenna. When the space is not limited and a higher gain is required, the proposed origami antenna can be transformed to a series antenna array by pulling the frame. In order to push the antenna array back to a single antenna, the frame for each antenna element size must be different. The frame and supporting dielectric materials are built using a three-dimensional (3D) printer. The conductive patterns are inkjet-printed on paper. Thus, the proposed origami antenna is built using hybrid printing technology. The 10-dB impedance bandwidth is 2.5–2.65 GHz and 2.48–2.62 GHz for the single-antenna and array mode, respectively, and the peak gains in the single-antenna and array mode are 5.8 dBi and 7.6 dBi, respectively. The proposed antenna can be used for wireless remote-sensing applications.