bluuebunny/crossref_metadata_2025 huggingface dataset:
Alman Ordusunun II. Dünya Savaşı’nda Sovyet Rusya’ya Karşı Düzenlediği Barbarossa Harekatı’nın Başlangıcı ve Türk Basını
Authors: Eraslan Metehan , Vuralgil Latif Burak
Published: November 2024

Almanlar, 23 Ağustos 1939’da Sovyetler ile pakt yaptıklarında Bismarck döneminden beri süregelen iki cephede aynı anda savaşmama politikasını devam ettirmiştir. Sovyetler ise batıdaki en yakın düşmanıyla ittifak yapmayı başarmıştır. Bu ittifak 1 Eylül 1939’da başlayan İkinci Dünya Savaşından yaklaşık 2 sene sonra 22 Haziran 1941 tarihinde Almanların Sovyetler Birliği’ne savaş ilan etmesine kadar devam etmiştir. Uzun yıllar sürecek olan bu mücadelenin ilk aylarında meydana gelen aksaklıklar ve oluşan bloklar savaşın gidişatı üzerinde belirleyici bir rol oynamıştır. Hitler ve kurmaylarının kısa bir sürede biteceğine inandıkları bu savaşın planları dahi kış aylarını kapsayacak şekilde tasarlanmamıştır. Ancak bu inancın, Sovyetler Birliği’nin cephelerdeki direnci karşısında çok iyimser kaldığı fark edilmiş, belirlenen bölgelerin planlanan tarihlerde ele geçirilememesi ve kış aylarının başlaması Almanlar için sonun başlangıcı olmuştur. Alman ordusunun bu durumu başta İngiltere olmak üzere pek çok devletin Almanların yenileceğine dair inancını arttırmıştır. İngiltere’nin Sovyetlere yardım sağlamak amacı ile başlattığı görüşmeler Mihver Devletlerinin karşısında yeni bir bloğun oluşmasını sağlamıştır. Çalışmanın amacı Türk basınının, Barbarossa Harekatı’nın başlangıç süreciyle beraber girilen yeni savaş düzenini nasıl değerlendirdiğini ve konu hakkındaki görüşlerini incelemektir. Bu doğrultuda çalışmada, Akşam, Cumhuriyet, Tan ve Ulus gazeteleri seçilerek nitel araştırma yöntemlerinden doküman analizi kullanılmıştır. Türkiye’nin kara bağlantısına sahip olmamasına karşın hem Sovyetler hem de Almanya ile olan ilişkileri savaş süresi boyunca tüm devletlerin ilgisini çekmiş, iki tarafın da Türkiye’nin savaşa dahil olması amacıyla yaptığı baskılar bu dönem artarak devam etmiştir. Hem diplomatik hem de medya aracılığı ile bu baskılara sık sık yanıt verilmiş ve Türkiye’nin savaş dışılığı konusu savunulmuştur. Bu noktada Türk basınından yola çıkılarak Türkiye’nin taraf olduğu ya da bir tarafa meyilli olduğu iddialarına da cevap aranmıştır.
Social Interaction Skills Collaboration Model of Autism Spectrum Disorder: Bibliometric Analysis in Publication 2013-2023
Authors: Phytanza Diajeng Tyas Pinru , Purwanta Edi , Hermanto Hermanto
Published: November 2024

This study aims to determine the development of scientific publication trends related to collaboration models on social interaction skills of children with autism spectrum disorders in the range of 2013 - 2023 in Crossref, PubMed and Scopus indexed scientific publications. This research focused on the following questions: (1) how is the productivity of publications? (2) what thematic areas are of most interest to academics? (3) future study opportunities that still need further research. This research uses a bibliometric analysis approach. The visualization process is supported using VOSviewer software. There are 1000 scientific publication articles in the range of 2013 - 2023. Scientific publications are dominated in the form of: (1) book; (2) book chapter; (3) journal article; (4) posted content and (5) proceedings. In the keyword density visualization section, it is presented into 6 clusters, namely: (1) asd; (2) child; (3) behavior; (4) autism spectrum disorder; (5) adult and (6) adolescent. Mapping related to the development of publication trends provides information for future study opportunities that are still rarely carried out further research such as: (1) social support, (2) life satisfaction, (3) pcit (parent child interaction therapy), (4) role, (5) differential diagnosis and (6) neurodevelopmental disorder.
Análise do teor de umidade como parâmetro de qualidade na produção de farinhas de trigo
Authors: Soares Luiza Victoria Ferreira , Souza Cristiane Daliassi Ramos de
Published: November 2024

A farinha de trigo é essencial na panificação e confeitaria, e sua qualidade depende de fatores como o teor de umidade, que afeta a durabilidade e as propriedades sensoriais dos produtos. O controle desse parâmetro é crucial para garantir a vida útil do produto e sua conformidade com as normas vigentes. Nesse contexto o presente artigo possui como objetivo geral investigar o teor de umidade na produção de farinha de trigo na empresa alpha como parâmetro de qualidade e conformidade com a norma vigente. Este estudo investigou o teor de umidade em três tipos de farinha de trigo produzidos pela empresa Alpha, como parâmetro de qualidade. Os resultados mostraram que a farinha comum apresentou 13,60% ± 0,251 de umidade, a farinha com fermento teve 13,11% ± 0,398, e a farinha para panificação, 13,47% ± 0,294. Todos os tipos estavam abaixo do limite máximo de 15%, conforme as normas do Ministério da Saúde e do MAPA.
Paralisia Cerebral e ferramentas de triagem nutricional, uma revisão integrativa de literatura
Authors: Teles Marcilene Menezes , Oliveira Larissa Marrocos de
Published: November 2024

A paralisia cerebral (PC) é definida como um grupo de distúrbios permanentes do desenvolvimento do movimento e postura, causando limitações das atividades funcionais atribuídas a alterações não progressivas, que costumam ocorrer durante o desenvolvimento do cérebro fetal ou infantil. Tem sua prevalência estimada no Brasil em aproximadamente 7 a cada 1000 nascidos vivos. Alterações de motilidade gastrointestinal e orofacial impõem a estas crianças um risco aumentado de desnutrição. Objetivo: O objetivo desse trabalho foi descrever a importância das ferramentas de triagem e de avaliação nutricional nesta população. Metodologia: Foi realizada uma revisão narrativa de literatura, por meio da estratégia de busca PICO, através da pergunta norteadora: “As ferramentas de triagem nutricional durante a admissão podem auxiliar no diagnóstico de risco nutricional nas crianças portadoras de paralisia cerebral?” Resultados: Apesar de não haver ferramentas de triagem específica para essa população, a STRONG Kids tem sido muito utilizada, com resultados semelhantes aos achados de antropometria. Ainda assim, essa é uma população de risco, que requer acompanhamento periódico e uso de curvas específicas para PC.
Diagnóstico tardio de tireoidite de Hashimoto e suas graves repercussões clínicas: Relato de caso
Authors: Buraqui Maria Clara Collodetto , Hernandes Sandra Regina Chahuan Tobji , Souza Géssica Dorta , Oliveira Laura Jane Monteiro de
Published: November 2024

A Tireoidite de Hashimoto é uma doença autoimune, caracterizada pela infiltração linfoplasmática e atrofia do parênquima tireoidiano, resultando na diminuição ou perda de atividade da glândula, realizado pela presença de anticorpos com antígenos tireoidianos. O diagnóstico é realizado por meio de manifestações clínicas comuns, elevação de TSH e a redução da atividade hormonal da glândula com positividade dos autoanticorpos. O tratamento consiste na reposição da tiroxina através de medicação.  As manifestações clínicas tardias, como déficit do crescimento e derrames cavitários, são manifestações graves e raras observados em pacientes com diagnóstico tardio. O estudo tem por objetivo relatar o caso clínico de paciente pediátrico com diagnóstico tardio de Tireoidite de Hashimoto e suas repercussões clínicas graves em serviço de Endocrinologia Pediátrica do Hospital Universitário Maria Aparecida Pedrossian, por meio de prontuário médico eletrônico e exames complementares realizados pela paciente. Sua finalidade é   evidenciar a importância do diagnóstico precoce da doença para melhor prognóstico e qualidade de vida dos pacientes.
Manejo da crise de ansiedade no pronto socorro: Uma revisão de literatura
Authors: Arruda Hyággo Phernanddo Nolêto , Lino Lucas Arruda , Mendes Luis Miguel Carvalho , Dovera Pablo Diego Duarte , Bernardes Andersanny Moura , Torres Gilmar José , Couto Carla Cristina Zanchin , Carvalho Maria Eduarda Amorim Yamanoi de , Neves Yasmin Louise Ribeiro
Published: November 2024

Introdução: A crise de ansiedade é uma condição comum que leva muitos pacientes ao pronto-socorro. Objetivo: Este artigo avalia a eficácia de intervenções padronizadas no manejo dessas crises, visando reduzir o tempo de permanência, melhorar a acurácia diagnóstica e aumentar a satisfação do paciente. Também examina o impacto de equipes multidisciplinares e tecnologias emergentes na saúde mental em emergências. Metodologia: Esta revisão de literatura analisou estudos recentes sobre intervenções no pronto-socorro, incluindo tratamentos farmacológicos e não farmacológicos. Resultados: Os dados mostram que a administração de benzodiazepínicos proporciona alívio rápido dos sintomas. Intervenções não farmacológicas, como técnicas de respiração e terapia cognitivo-comportamental breve, também demonstraram benefícios significativos. Discussão: O uso de benzodiazepínicos deve ser monitorado devido ao risco de dependência. Intervenções não farmacológicas são uma alternativa segura, especialmente quando combinadas com suporte psicológico. Conclusão: O manejo das crises de ansiedade no pronto-socorro exige uma abordagem integrada que una intervenções farmacológicas e não farmacológicas. A adesão a diretrizes baseadas em evidências e a educação contínua dos profissionais são cruciais para melhorar os desfechos dos pacientes. Pesquisa adicional é necessária para desenvolver novas estratégias de intervenção e garantir a melhor assistência possível.
Expectativas e sentimentos das gestantes e puérperas positivadas para SARS-CoV-2
Authors: Medeiros Carolina Campos , Alves Karine Cavoli , Pereira Lorenza , Galdino Cíntia Valéria , Almeida Eric Gustavo Ramos , Sliva Gabriel Cicero Araujo
Published: November 2024

O objetivo deste estudo é analisar os sentimentos despertados pelas gestantes e puérperas que já tiveram SARS-CoV-2, no período gravídico puerperal. Pesquisa exploratória de abordagem qualitativa, quantitativa e descritiva. Realizada na casa de saúde da mulher e Ambulatório Médico de Especialidades no período de agosto de 2022 a novembro de 2022, tendo como amostra de estudo gestantes e puérperas positivadas com SARS-CoV-2 no período da Pandemia. Dados coletados por meio de uma entrevista semiestruturada, através de uma entrevista com as participantes. A análise foi realizada pela caracterização da clientela e categorização da fala das mulheres formando categorias de análise do estudo a ser discutida de acordo com a literatura pertinente. O presente estudo foi submetido ao Comitê de Ética e Pesquisa do Centro Universitário de Valença (UNIFAA), cujo o CAAE de número 61744522.6.0000.5246 e aprovada pelo parecer 5.608.015. Participaram do estudo 14 puérperas que tiveram SARS-CoV-2 quando estavam classificadas como gestantes. Foram criadas 03 categorias de análise de estudo, a saber: 1) “As angústias das puérperas positivadas quando gestantes e seu acolhimento frente aos profissionais de saúde”; 2) “Os sentimentos e medos diante do resultado positivo e como estão essas mulheres hoje após suas experiências”; e 3) “Dificuldades, desafios e privações encontradas na confirmação do diagnóstico de SARS-CoV-2”. Conclui-se com o presente estudo que os sentimentos despertados pelas puérperas que já tiveram SARS-CoV-2, no período gravídico em sua maioria foram medo, ansiedade, angústia devido a gestação e as possíveis complicações do vírus.
Correlação entre a dieta e o neurodesenvolvimento em lactentes com sífilis congênita no Nordeste brasileiro
Authors: Moura Victoria Santos , Lopes Izailza Matos Dantas , Ribeiro Ana Beatriz Silva , Figueiredo Mariana Santos Alencastro , Gomes Zuleide Barros Luna , Santos Gabryelle Eduarda Gama dos
Published: November 2024

O objetivo deste trabalho é avaliar a influência da dieta e a sua correlação com o desenvolvimento neuropsicomotor de lactentes com sífilis congênita no Hospital e Maternidade Santa Isabel em Aracaju-SE. Tal temática é de interesse para a saúde pública, visto o número crescente de casos da doença no Nordeste brasileiro e a escassez de informações sobre o assunto. Para o desenvolvimento do trabalho, dados foram coletados a partir do atendimento de crianças de 0 a 2 anos, com o diagnóstico de sífilis congênita, acompanhadas de seus responsáveis. O processo de pesquisa foi dividido em entrevista dos genitores acerca dos hábitos da criança e na aplicação do Teste de Denver II. A partir disso, foi realizada a correlação entre a dieta e o desenvolvimento do paciente, que demonstrou a importância de novas abordagens e pesquisas sobre o tema, em virtude da quantidade de fatores que podem influenciar no processo de crescimento e aquisição de novas habilidades na criança. Além disso, ficou clara a necessidade de intervir diretamente nos fatores de riscos, impedindo as sequelas da doença nessa população.
COVID-19-Associated Nephropathy: An Emerging Clinical Entity
Authors: Piko Nejc , Ekart Robert , Bevc Sebastjan
Published: November 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new pathogen that was responsible for the global pandemic that started in Wuhan, China in 2019. It causes COVID-19, manifesting as viral pneumonia with concomitant acute respiratory failure and, in certain cases, multiorgan failure and death.

Kidney involvement is common and can be aetiologically heterogeneous. Acute kidney injury is mostly caused indirectly, especially in the context of systemic inflammation, hypoxaemia, hypotension, shock, and increased oxidative stress. Complement activation, tubulointerstitial damage, and endothelial dysfunction with resultant thromboses are also important factors in kidney injury. Histologically, SARS-CoV-2 was found to induce predominant tubulointerstitial changes and in some cases, glomerular changes. In a certain subgroup of patients with the APOL1 high-risk allele variant, a collapsing glomerulopathy, similar to HIV-associated nephropathy, was found. This entity was later named COVID-19-associated nephropathy. In this article, the authors present the pathophysiology behind SARS-CoV-2-related kidney involvement and the development of COVID-19-associated nephropathy.
EMIGRATIONAL TRAUMA OF WAR IN VLADYSLAV IVCHENKO’S LITERARY VISION
Authors: Pukhonska Oksana
Published: November 2024

The Russian war against Ukraine has been going on for 10 years and continues to influence the national culture in a very distinctive way. Over the past decade, this traumatic event has created a peculiar cultural discourse where literature has taken a special place. Its new stage, which began in February 2022, not only gave rise to an even more intense artistic reaction to the lived experience of Ukrainians, but also opened up prospects for new literary themes and methods of their interpretation. Trauma in its individual and national dimensions naturally became the central issue in such texts. Vladyslav Ivchenko’s book “After the 24th” clarifies and complements the discourse of the cultural reception of the war, describing its front and rear experiences in real time. The trauma of forced emigration, triggered by the full-scale Russian invasion on February 24, 2022, is a new problematic aspect that requires special attention.
The author of the paper analyzes a new dimension of the emigrational trauma, related to the war experiences of Ukrainian refugees. Through the fates of three individual women, Vladyslav Ivchenko demonstrates the prospects of Ukrainian national trauma, which includes the loss of homes, loved ones, and, most importantly, the belief that the world and life could return to what they were before February 24, 2022. The trauma of forced emigration continuously offers new perspectives for understanding the behavior of a national culture during the war, particularly in the context of creating wartime literature, which is an effective component of the trauma recovery process. Literature plays an important role in this context, and Ivchenko’s book exemplifies this role most effectively.
“THE SERMON ON THE DEC EASED” BY HRYHORII TSAMBLAK: RECENSIONS, POETICS, AND STYLE
Authors: Peleshenko Yurii
Published: November 2024

The copy of “The Sermon on the Deceased” by Hryhorii Tsamblak, preserved in the library of the Kyiv Cave Monastery, was written in the 16th or early 17th century at the Belarusian Suprasl Monastery. This sermon is a part of the so-called “Hryhorii Tsamblak’s Book,” which may have been compiled by the author himself during his tenure as Kyivan metropolitan.
The examined copy of the “The Sermon on the Deceased” and the copy of the same work kept in the scientific library of the Lithuanian Academy of Sciences in Vilnius are of Belarusian origin and differ significantly from the copies created in the Moscow principality. Therefore, it can be assumed that the Kyiv and Vilnius codices originate from a common protograph that was modified either by the author himself or by a scribe in the territory of the Grand Duchy of Lithuania.
In “The Sermon on the Deceased,” Hryhorii Tsamblak shares his thoughts on the Christian custom of commemorating the dead. The preacher optimistically proclaims an eschatological perspective for Christians. The didactic purpose of Tsamblak’s sermon is to illuminate the futility of earthly concerns and efforts. The ontological perspective for the righteous pertains to the hope of the resurrection of the dead and eternal life. Based on numerous examples of human activity, such as the hard lives of warriors, farmers, sailors, and ore miners, the preacher attempts to illustrate the concept of “the vanity of vanities” and “the hurricane of human life that passes quickly.” Tsamlak argues that the Christian’s axiology should oppose the cult of enrichment, power, and vanity. Metaphorically and symbolically, he portrays the work of a farmer hoping for a good harvest, which represents the imperishable — eternal life in Christ.
“The Sermon on the Deceased” was influenced by the sermons of John Chrysostom and, probably, by one of the works of Macarius the Great. The style of Tsamblak’s sermon can be defined as emotionally expressive.
Shadow footprints and the provision of digital behavioral data
Authors: Clements Estelle , Horwood Marcus
Published: November 2024

We introduce the concept of shadow footprints as a means of understanding privacy challenges in the information environment. Growing emphasis on the impact of citizens sharing their personal data goes far beyond the individual, with the increased capacity of algorithms to formulate shadow footprints that inform as much about persons absent from data, as persons present. Data extrapolated from small groups have demonstrated robust utility when applied to larger populations. Individuals who have opted to keep their data private, or who have been unaware that data about their private lives has been extracted from the involvement of their fellow citizens from digital behavioral data, suggest the possibility that informed consent has been circumvented, or not fully investigated. This is increasingly concerning when one considers the potential to impact the body politic through behavioral manipulation drawn from such data. These issues must be considered in the context of ethical and litigious standards to inform robust policy frameworks, legal regulation, and the provision of incentives necessary to provide guidance and civic protections, as well as adherence to good ethical practice.
The Owl of Minerva Takes Fright
Authors: McCrone David
Published: November 2024

This article, based on a talk given in November 2023, seeks to place contemporary Scotland in the context of broader social and political change. The last quarter of a century, marked by a devolved Parliament, has also seen the rise of increasingly aggressive individualism, a retreat from the social, and a populist right which threatens a crisis for democracy globally. Where, and how, does Scotland stand in these contexts?
Whatever Happened to the Policy Power House? Public Policy after Devolution
Authors: Keating Michael
Published: November 2024

Scottish devolution built on an existing structure of administrative devolution around the Scottish Office. The architects of devolution gave a lot of attention to the design of the Scottish Parliament but less to policy-making and delivery. Much of the policy capacity built up since the 1960s had been run down under Conservative governments after 1979. The new Scottish institutions faced a number of institutional, economic and political constraints on making their own policies. There have been significant divergences from policy in England but often these take the form of England diverging while Scotland remained the same. Successive Scotland Acts in 2012 and 2016 were guided by political considerations rather than examination of the powers and instruments needed. There has been a lack of the policy innovation that might have been expected in the new system. The argument is illustrated by examples, together with some footnoted personal reflections from half a century of following policy making in Scotland. There is no attempt to be comprehensive but rather to highlight key issues and trends.
Геоинформационное обеспечение оценки доступности древесного сырья лесозаготовительных территорий
Authors: Мохирев Александр Петрович , Медведев Сергей Олегович , Якушева Мария Олеговна , Зырянов Михаил Алексеевич
Published: November 2024

Эффективность принятия управленческих решений в любой сфере деятельности человека обосновывается доступностью, актуальностью и полнотой располагаемой информации. В работе лесопромышленного комплекса вопрос информационного обеспечения процессов стоит наиболее остро: характерной особенностью отрасли является широкая географическая протяженность лесных массивов, различающихся по качественным и объемным параметрам, а также постоянно претерпевающих изменения по естественным или антропогенным причинам. В этих условиях все субъекты хозяйствования (от государственного управленческого аппарата до мелкого лесозаготовительного предприятия) заинтересованы в получении полной и достоверной информации об объектах лесопользования. Такая информация позволяет определить уровень доступности лесных ресурсов на той или иной территории. Проблемой становится сложность сбора (получения) этой информации, а также отсутствие практических методик ее обработки и оперативного применения. Целью представленного исследования является разработка методологической основы обеспечения субъектов лесопользования актуальной информацией для создания и функционирования географической информационной системы, с помощью которой оценивается доступность древесных ресурсов. В статье предложена информационно-логическая и математическая модели процесса определения доступных лесных участков с использованием географических информационных систем. На основе полученных результатов создан новый геоинформационный ресурс, предназначенный для лесничеств Красноярского края. На ресурсе размещается информация по транспортной инфраструктуре, объемам лесозаготовки и неосвоенных лесов, плотности сети лесных дорог, а также иная профильная информация, необходимая для принятия эффективных управленческих решений, призванных поддерживать устойчивое развитие предприятий, регионов и отрасли в целом.
К вопросу определения системы высот, реализуемой методом хронометрического нивелирования
Authors: Гиенко Елена Геннадьевна , Ганагина Ирина Геннадьевна
Published: November 2024

Приведена концепция международной системы отсчета высот IHRS, в которой вертикальные координаты точек определяются геопотенциальными числами. Этой концепции соответствует метод хронометрического нивелирования, где по измерению релятивистского смещения частоты атомных стандартов определяется разность гравитационных потенциалов. Представлены основные направления развития метода. Отмечены недостатки реализаций существующих систем высот, где основной из них – накопление ошибок с увеличением расстояния. Рассмотрены вопросы перехода от разностей гравитационных потенциалов, измеряемых методом хронометрического нивелирования, к разностям высот в гравитационном поле Земли: задание исходной высоты стационарного стандарта, неопределенности в формулах, разномасштабность высот, вызванная выбором знаменателя в основной формуле хронометрического нивелирования. При переходе хронометрического нивелирования на сантиметровый уровень точности неопределенность формул и выбор знаменателя будут иметь значение.
Computation of Novel Binomial Series using Bivariable Geometric Series
Authors: Annamalai Chinnaraji
Published: November 2024

Nowadays, the growing complexity of mathematical and computational modelling demands the simplicity of mathematical equations for solving today’s scientific problems and challenges. In this paper, the author introduces a novel binomial series and its theorems using the geometric series with two variables. This computing technique can enable the researchers for further involvement in research and development.
The Comparison of Free Cell and Immobilization Cell Fermentation on Bioethanol Production from Sorghum Stem by SSF and SHF Method
Authors: Permanasari Ayu Ratna , Syamfitri Arum , Maharani Devina , Setyaningrum Sinta , Wibisono Wahyu
Published: November 2024

Bioethanol is a new and renewable energy source that can be produced from plants or crops containing sugars, starch, and lignocellulose. Sorghum stem contain a significant amount of sugar and lignocellulose. This study utilized sorghum stem in bioethanol production using Separated Hydrolysis and Fermentation (SHF) and Simultaneous Saccharification and Fermentation (SSF) methods. These two processes are generally used in the prouction of bioethanol with raw materials containing lignocellulose. However, raw materials derived from sweet sorghum stems has not been widely used in the previous studies. This study aimed to determine the effect of fermentation using free cell and cell immobilization techniques on various pH, as well as to identify the most optimal fermentation method (SHF or SSF) for producing the highest ethanol content in sorghum stem fermentation.  The fermentation was conducted at pH levels of 3, 4, and 5. Sorghum stem were processed into powder and followed by delingnification process by 3% of NaOH solution to degrade the lignin content. The hydrolysis process of sorghum stem used cellulase enzymes as the biocatalyst. Fermentation was carried out using Saacharomyce in term of dry yeast for 72 h. The results showed that the increasing within the range pH of 3-5 will increase the ethanol concentration. Freecell technique gave the better result over the immobilized. The best result reached out the ethanol concentration of 13.04 % by the SSF.
Procesamiento de lenguaje natural en la Salud Mental: Revisión de alcance
Authors: Alemán Acuña Reyk Sayk , Pereira Montiel Eider , Torres Silva Ever Augusto , Montoya Arenas David Andrés
Published: November 2024

Esta revisión tiene como objetivo analizar el uso del procesamiento de lenguaje natural en las investigaciones de trastornos mentales en adultos, como la depresión, ansiedad y los sentimientos de duelo. Realizando una búsqueda en cuatro bases de datos relevantes (PubMed, IEEE, ScienceDirect y LILACS) publicado en español e inglés desde 2017 hasta 2022 sin restricciones de país de origen. Se utilizaron términos MeSH y de texto libre para identificar estudios sobre la implementación del procesamiento del leguaje natural en la detección de condiciones de salud mental como la ansiedad, depresión y sentimientos de duelo. Se encontraron un total de 136 estudios relacionados, de los cuales se seleccionaron 32 artículos para la revisión. Donde se muestra un incremento de la utilización del procesamiento de lenguaje natural en la salud pública, espacialmente entre los años 2020 y 2022. Además, se observó que las redes sociales son una fuente de datos frecuentemente utilizada en estos estudios, y que los modelos de aprendizaje automático supervisados son los más prevalentes en la detección de depresión y ansiedad. El procesamiento de lenguaje natural puede mejorar la detección de problemas de salud mental en la salud pública. Los métodos de aprendizaje supervisados supervisado son los más comunes, pero los algoritmos basados en aprendizaje profundo presentan perspectivas innovadoras y se espera que esta tecnología siga en aumento para mejorar la detección y tratamiento de trastornos mentales. Es importante continuar investigando y desarrollando estas tecnologías para su aplicada en la salud pública.
Adaptación Cultural y Validación de la Escala de Actitudes hacia los Roles de Género
Authors: Gómez Ibáñez Tanya Arami , Cappello Lezcano Giovanna Sofía , González Hugo Arsenio , Bagnoli Peralta Ana Laura
Published: November 2024

El presente trabajo consistió llevar a cabo la adaptación cultural y validación de la escala Actitudes hacia los Roles de Género de San Martín Adrián y Cuba Hurtado (2020) en la población paraguaya. La muestra estuvo compuesta por 433 participantes, de los cuales 302 son mujeres y 131 hombres, con un rango de edad de18 a 66 años. El resultado del proceso fue una escala de 19 de ítems, que se distribuyeron en 6 factores, en contraste con las validaciones anteriores de la escala que eran unidimensionales. Si bien presentó un índice de confiabilidad aceptable (.797), las diferencias se presentan a partir de la medición de validez del constructo, por lo que se recomienda utilizarla con modificaciones.
Escala de propensão à agressividade no trânsito (EPAT): Adaptação brasileira
Authors: Santos Walberto , Malheiros da Costa Thicianne , Possidônio de Sousa Emanuela Maria , Silva Sousa Roger , De Araújo Fontes Barroso Nicolle
Published: November 2024

Este estudo objetivou conhecer evidências de validade e precisão da Escala de Propensão à Agressividade no Trânsito (EPAT). Especificamente, no primeiro estudo, realizaram-se a tradução, a validação semântica e a análise dos itens; no segundo, averiguaram-se suas propriedades psicométricas. No Estudo 1, participaram 41 universitários, idade média de 21 anos (DP = 4,6). O Estudo 2 contou com 271 motoristas, idade média de 35,1 (DP = 13,5). Os participantes responderam aos instrumentos: EPAT, Inventário de Busca de Sensações, Escala de Autocontrole, Questionário de Agressão de Buss-Perry, Inventário dos Cinco Grandes Fatores de Personalidade e perguntas biossociodemográficas. Os resultados do Estudo 1 apontaram que a EPAT abarca os distintos graus de reação de agressividade. No Estudo 2, apoiaram sua adequação psicométrica, indicando uma estrutura unifatorial, e adequada validade convergente. Os resultados foram discutidos à luz da literatura.
Efecto de dos ambientes virtuales para el aprendizaje de la ciencia en estudiantes universitarios
Authors: Domínguez Morales Delia - De Jesús , Gómez Fuentes Agustín Daniel
Published: November 2024

El propósito del estudio consistió en comparar dos tipos de ambientes virtuales de enseñanza-aprendizaje: la enseñanza ostensiva por medio de videos y la enseñanza por instrucciones, en el aprendizaje de relaciones de clase de elementos químicos en estudiantes universitarios, mediante un arreglo de igualación de la muestra de primer y segundo orden, para relacionar el símbolo, nombre y grupo dados en la tabla periódica. Participaron 50 estudiantes de licenciaturas que atañen su campo de conocimiento a la Química, de una universidad de Sonora, divididos equitativa y aleatoriamente en 10 grupos. Se utilizó un diseño factorial con ocho grupos experimentales y dos control, con pre-post test, entrenamiento y evaluación, se configuró la retroalimentación continua al desempeño durante el entrenamiento con las palabras correcto e incorrecto. Los resultados sugieren que el ambiente virtual en la enseñanza ostensiva, donde un experto muestra un ejercicio en tareas de igualación de la muestra de primer y segundo orden, tiene mayores efectos que el ambiente virtual que se apoya en la enseñanza por instrucciones explícitas de los ejercicios en las tareas de igualación. Se destaca la importancia de la enseñanza ostensiva como un recurso didáctico que puede combinarse con las instrucciones en el diseño de ambientes virtuales de enseñanza-aprendizaje, se asume que la práctica del estudiante favorece el aprendizaje de la ciencia, en específico cuando aprende haciendo y observando ejercicios e instrucciones dados por un experto en el área.
Highly parallel bending tests for fungal hyphae enabled by two-photon polymerization of microfluidic mold
Authors: Brinkmann Steffen , Schrader Marcel , Meinen Sven , Kampen Ingo , Kwade Arno , Dietzel Andreas
Published: November 2024

Filamentous microorganisms exhibit a complex macro-morphology constituted of branched and cross-linked hyphae. Fully resolved mechanical models of such mycelial compounds rely heavily on accurate input data for mechanical properties of individual hyphae. Due to their irregular shape and high adaptability to environmental factors, the measurement of these intrinsic properties remains challenging. To overcome previous shortcomings of microfluidic bending tests, a novel system for the precise measurement of the individual bending stiffness of fungal hyphae is presented in this study. Utilizing two-photon polymerization, microfluidic molds were fabricated with a multi-material approach, enabling the creation of 3D cell traps for spore immobilization. Unlike previous works applying the methodology of microfluidic bending tests, the hyphae were deflected in the vertical center of the microfluidic channel, eliminating the adverse influence of nearby walls on measurements. This lead to a significant increase in measurement yield compared to the conventional design. The accuracy and reproducibility of bending tests was ensured through validation of the measurement flow using micro-particle image velocimetry. Our results revealed that the bending stiffness of hyphae of Aspergillus niger is approximately three to four times higher than that reported for Candida albicans hyphae. At the same time, the derived longitudinal Young’s Modulus of the hyphal cell wall yields a comparable value for both organisms. The methodology established in this study provides a powerful tool for studying the effects of cultivation conditions on the intrinsic mechanical properties of single hyphae. Applying the results to resolved numerical models of mycelial compounds promises to shed light on their response to hydrodynamic stresses in biotechnological cultivation, which influences their expressed macro-morphology and in turn, product yields.
Flame retardants of the future: biobased, organophosphorus, reactive or oligomeric
Authors: Howell Bob A.
Published: November 2024

Polymeric materials have been a great boon to the development and wellbeing of mankind. However, in the main, these materials are flammable and must be flame retarded for most applications. Many substances have been utilized to impart a measure of flame retardancy. The most widely used and most effective have been organic: organohalogen and organophosphorus compounds. Organohalogen compounds have been popular, low-cost, very effective flame retardants for polymeric materials. However, with the recognition that these compounds readily migrate from a polymer matrix into which they have been incorporated, persist in the environment and pose serious risks to human health, the use of organophosphorus compounds has become prominent. In particular, organophosphorus compounds of appropriate structure derived from readily-available, renewable, low-cost, non-toxic biobased precursors are attractive. Avoidance of the issues of environmental persistence and toxicity associated with organohalogen compounds is possible with these materials. Migration from a polymer matrix may be removed as a deficiency through the use of reactive compounds, i.e., compounds that may be incorporated directly into the polymer structure either by copolymerization or grafting, or oligomeric compounds. Oligomeric materials of branched structure display characteristics of broad compatibility, high effectiveness and lack of migration.
SER project: analysis of the skills profile of students from three Portuguese professional schools
Authors: Neves Maria de Lurdes , Rodrigues Rosa
Published: November 2024

Introduction

This research aims to evaluate the effectiveness of the SER project, which focuses on autonomy and curricular flexibility. Additionally, it seeks to assess the profiles of students from three Portuguese professional schools in relation to their social and emotional skills, self-concept and personal development after project implementation.

Methods

The sample comprised of 381 students aged between 15 and 20 years. The study employed a quantitative methodology with data collected using the Social and Emotional Skills Questionnaire, the Self-Concept Scale, and the Positive Youth Development Scale.

Results

School 1 includes students who tend to exhibit high levels of Social Awareness and Cooperation. School 2, while not excelling in any particular competencies, shows above-average values across all assessed dimensions. Finally, students at School 3 demonstrate elevated levels in Interpersonal Relationships, Self-Esteem, Self-Management, Self-Concept, and Decision-Making.

Discussion

It was found that student profiles differ depending on the school they attend, and it was found that statistically significant differences occur between School 1 and School 2 in Decision-Making and between School 1 and School 3 in Interpersonal Relationships.
Neutrophils promote the activation of monocytes via ROS to boost systemic antitumor immunity after cryo-thermal therapy
Authors: Wang Shicheng , Zhang Zelu , Wang Junjun , Lou Yue , Zhu Yongxin , You Jiaqi , Liu Ping , Xu Lisa X.
Published: November 2024

Background

The characteristics of the tumor immunosuppressive microenvironment represent a major challenge that limits the efficacy of immunotherapy. Our previous results suggested that cryo-thermal therapy, a tumor ablation system developed in our laboratory, promotes macrophage M1-type polarization and the complete maturation of DCs to remodel the immunosuppressive environment. However, the cells that respond promptly to CTT have not yet been identified. CTT can cause extensive cell death and the release of danger-associated molecular patterns and antigens. Neutrophils are the first white blood cells recruited to sites of damage and acute inflammation. Therefore, we hypothesized that neutrophils are the initial cells that respond to CTT and are involved in the subsequent establishment of antitumor immunity.

Methods

In this study, we examined the kinetics of neutrophil recruitment after CTT via flow cytometry and immunofluorescence staining and explored the effect of neutrophils on the establishment of systemic antitumor immunity by in vivo neutrophil depletion and in vitro co-culture assays.

Results

We found that CTT led to a rapid and strong proinflammatory neutrophil response, which was essential for the long-term survival of mice. CTT-induced neutrophils promoted the activation of monocytes via reactive oxygen species and further upregulated the expression of IFN-γ and cytotoxic molecules in T and NK cells. Adoptive neutrophil transfer further enhanced the antitumor efficacy of CTT in tumor models of spontaneous and experimental metastasis.

Conclusion

These results reveal the important role of neutrophil‒monocyte interactions in the development of anti-tumor immunity and highlight that CTT could be used as an immunotherapy for targeting neutrophils and monocytes to enhance antitumor immunity.
Unraveling the role of cancer-associated fibroblasts in B cell lymphoma
Authors: Mukherjee Prithviraj , Ansell Stephen M. , Mondello Patrizia
Published: November 2024

Recent breakthroughs in research have sparked a paradigm shift in our understanding of cancer biology, uncovering the critical role of the crosstalk between tumor cells and the immune cells of the tumor microenvironment (TME) in malignant transformation. Fibroblasts have long been viewed as ancillary participants in cancer progression, often eclipsed by the prominence given to malignant cells. Novel investigations, however, have increasingly acknowledged the essential part played by the fibroblasts and their phenotypic doppelganger cancer-associated fibroblasts (CAFs) in fostering immunosuppression and promoting tumor progression. Here we review the cell-of-origin from which CAFs derive and their altered programs compared to their normal counterpart. We will also discuss the complex interplay between CAFs and the surrounding immune cells of the TME in the context of solid tumors and B cell lymphomas, with a focus on the “reprogrammable” role of CAFs in immunosuppression, immuno-activation and immuno-avoidance, and their implications on drug resistance. Finally, we will examine the existing and plausible therapeutic approaches targeting CAFs as a strategy to enhance treatment response.
Distinct etiology of chronic inflammation – implications on degenerative diseases and cancer therapy
Authors: Maddipati Krishna Rao
Published: November 2024

Acute inflammation is elicited by lipid and protein mediators in defense of the host following sterile or pathogen-driven injury. A common refrain is that chronic inflammation is a result of incomplete resolution of acute inflammation and behind the etiology of all chronic diseases, including cancer. However, mediators that participate in inflammation are also essential in homeostasis and developmental biology but without eliciting the clinical symptoms of inflammation. This non-inflammatory physiological activity of the so called ‘inflammatory’ mediators, apparently under the functional balance with anti-inflammatory mediators, is defined as unalamation (un-ala-mation). Inflammation in the absence of injury is a result of perturbance in unalamation due to a decrease in the anti-inflammatory mediators rather than an increase in the inflammatory mediators and leads to chronic inflammation. This concept on the etiology of chronic inflammation suggests that treatment of chronic diseases is better achieved by stimulating the endogenous anti-inflammatory mediators instead of inhibiting the ‘inflammatory’ mediator biosynthesis with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Furthermore, both ‘inflammatory’ and anti-inflammatory mediators are present at higher concentrations in the tumor microenvironment compared to normal tissue environments. Since cancer is a proliferative disorder rather than a degenerative disease, it is proposed that heightened unalamation, rather than chronic inflammation, drives tumor growth. This understanding helps explain the inefficacy of NSAIDs as anticancer agents. Finally, inhibition of anti-inflammatory mediator biosynthesis in tumor tissues could imbalance unalamation toward local acute inflammation triggering an immune response to restore homeostasis and away from tumor growth.
Deciphering the role of NcRNAs in Pancreatic Cancer immune evasion and drug resistance: a new perspective for targeted therapy
Authors: Gong Yu , Gong Desheng , Liu Sinian , Gong Xiangjin , Xiong Jingwen , Zhang Jinghan , Jiang Lai , Liu Jie , Zhu Lin , Luo Huiyang , Xu Ke , Yang Xiaoli , Li Bo
Published: November 2024

Pancreatic cancer (PC) is a very aggressive digestive system tumor, known for its high mortality rate, low cure rate, low survival rate and poor prognosis. In particular, pancreatic ductal adenocarcinoma (PADC), which accounts for more than 90% of PC cases, has an overall 5-year survival rate of only 5%, which is an extremely critical situation. Early detection and effective treatment of PC is extremely difficult, which leads many patients to despair. In the current medical context, targeted therapy, as an important strategy for cancer treatment, is expected. However, the problems of immune escape and drug resistance in PC have become two major obstacles that are difficult to be overcome by targeted therapy. How to break through these two difficulties has become a key issue to be solved in the field of PC therapy. In recent years, non-coding RNAs (ncRNAs) have continued to heat up in the field of cancer research. NcRNAs play a pivotal role in gene regulation, cell differentiation, development, and disease processes, and their important roles in the genesis, development, and therapeutic response of PC have been gradually revealed. More importantly, ncRNAs have many advantages as therapeutic targets, such as high specificity and low side effects, making them a new favorite in the field of PC therapy. Therefore, the aim of this paper is to provide new ideas and methods for the targeted therapy of PC by reviewing the mechanism of action of four major ncRNAs (circRNAs, lncRNAs, miRNAs, siRNAs) in both immune escape and drug resistance of PC. It is expected that an effective way to overcome immune escape and drug resistance can be found through in-depth study of ncRNA, bringing a ray of hope to PC patients.
Plasticity in malaria parasite development: mosquito resources influence vector-to-host transmission potential
Authors: Oke Catherine E. , O’Donnell Aidan J. , Schneider Petra , Reece Sarah E.
Published: November 2024

Parasites rely on exploiting resources from their hosts and vectors for survival and transmission. This includes nutritional resources, which vary in availability between different hosts and changes during infections. For malaria (Plasmodium) parasites, sexual reproduction (sporogony) and subsequent development of oocysts, which produce sporozoites infectious to the vertebrate host, occurs in the mosquito vector. Mosquitoes in the field exhibit diversity in the amount and type of food they acquire, directly impacting the nutrients available for the replication and development of parasites. While the rate of parasite transmission from vector to host is influenced by the nutritional state of mosquitoes, whether this is due to resource limitation mediating parasite development and productivity is poorly understood. We use the rodent model parasite P. chabaudi and the vector Anopheles stephensi to ask how variation in the amount of sugar and blood provided to malaria-infected mosquitoes affects the potential for parasites to transmit from vector to host. We show that parasites in well-resourced mosquitoes reach a larger oocyst size earlier in development, suggesting faster growth, and have a 1.7-fold higher sporozoite burden than parasites whose vectors only receive sugar. However, this increase in productivity is only partly explained by oocyst development, suggesting that resource availability also impacts the ability of sporozoites to reach the salivary glands. This challenges the assumption of a simple relationship between the number or size of oocysts and onward transmission potential. Furthermore, our findings suggest malaria parasites may actively adjust oocyst growth rate to best exploit nutritional resources; while parasites in low-resourced mosquitoes exhibited a reduction in oocyst burden during sporogony, the remaining oocysts developed more rapidly in the later stages of oocyst development, catching up to reach a similar size to those in well-resourced mosquitoes. Understanding the impacts of resource availability for malaria transmission is urgent given that parasites encounter increasingly variable vectors as consequences of climate change and vector control tools.