bluuebunny/crossref_metadata_2025 huggingface dataset:
Pandemic Management of Coronavirus Disease of 2019: A Kuwait Perspective on the Example of Al-Adan Hospital
Authors: Alhadhoud Dr. Meshal A , Alsiri Dr. Najla F , Al-Salem Dr. Najla , Sibbel Prof. Rainer
Published: April 2021

Objective: Coronavirus Disease of 2019 (COVID19) as a pandemic could paralyze the operational system of healthcare organizations. However, the crisis management plan of COVID19 implemented in Al-Adan Hospital, Kuwait, has been successful. Therefore, this study aims to present the crisis management plan for COVID19 implemented in our institution. Design: Presenting and framing the prescriptive strategy of the crisis management approach adopted. The literature was further critically reviewed to reflect on the plan implemented to enrich the current experience and formulate future recommendations. Setting: Al-Adan Hospital, Kuwait. Main Outcome Measures: The prescriptive strategy adopted for the crisis management plan consists of three managerial frameworks: COVID19 team, COVID19 management strategy, and strategy for maintaining emergency healthcare services. Results: Balancing between the standardization model of implementing governmental regulations, and the personalization model of placing the patients and the employees at the center of the strategy, could explain the success of the plan. The strategy implemented could be further strengthened by elevating the principles of leaderships and encouraging health digitalization. Conclusion: This study presents a novel framework of crisis management for healthcare systems by raising the concept of balancing between the standardization and personalization models.
Kalkınma Odaklı Mekânsal Tasarım ve Uygulama Girişimlerinin Sürdürülebilirliğinin Değerlendirilmesi: Sakin Şehir Uzundere Örneğinde Bir Çalışma
Authors: ÖZGERİŞ Mustafa , KARAHAN Faris
Published: April 2021

Bu çalışma bir turizm merkezi ve aynı zamanda Sakin Şehir (Cittaslow) olan Uzundere’deki yerel kalkınma odaklı mekânsal tasarım ve uygulama çalışmaları ile sosyo-ekonomik, kültürel ve sanatsal faaliyet ve programlar üzerinde yürütülmüştür. Çalışmanın amacı gerek turizmle ilişkili gerekse de turizmden bağımsız olarak, devam eden ve/veya tamamlanan kalkınma odaklı girişimlerin sürdürülebilirliğini değerlendirmektir. Çalışma kapsamında odak grup, yerel halk grubu ve ziyaretçi grubu olmak üzere üç farklı grupla anket yapılmıştır. Anketler ANOVA ve T-Testi yapılarak analiz edilmiştir ve katılımcı grupların verdiği cevaplar arasındaki farklılıklar tartışılmıştır. Çalışmanın sonucunda özellikle kırsal doku ve kırsal kültürün hakim olduğu turizm alanlarında yapılacak olan mekânsal tasarım ve uygulama çalışmalarında estetik değerlendirme süreçlerinin işletilmesi ve mekânsal tasarım ve uygulama girişimlerinin sürdürülebilirliği için koruma-kullanıma ek olarak faydalanma dengesinin de karşılaması gerektiği vurgulanmaktadır.
Peyzaj Mimarlığı Uygulama Alanlarında İş Sağlığı ve Güvenliği: Ankara Örneğinde Şantiye Hizmetlerinin Değerlendirilmesi
Authors: GÜLER Umut
Published: April 2021

Son yüzyılda, teknolojik gelişmelere paralel olarak sanayileşmedeki hızlı artış, iş kazalarına da yansımaktadır. İş sağlığı ve güvenliği, insanlığın çalışma gereksinimi duymaya başlamasından beri kavramsal olarak karşımıza çıkmaktadır. İlkel toplumlardan günümüze iş bölümü yapılmakta ve yapılan işlerde standartlaşma ve çeşitlilik, işçi sağlığı ve güvenliğini zorunlu duruma getirmektedir. Peyzaj mimarlığı uygulama alanlarında yürütülen her proje birbirinden farklı iş gücü, teknik ve mekânlar içermekte ve bu farklılıklara bağlı olarak çalışanlar açısından farklı risk ve tehlikeler meydana getirmektedir. Bu çalışmada peyzaj mimarlığı alanında iş sağlığı ve güvenliği ile ilgili tanımları ortaya koyarak mevzuat ve uygulamaya yönelik gelişim aşamalarının Türkiye’de nasıl ilerlediği irdelenmektir. Bu amaçla peyzaj mimarlığı uygulama alanlarında şantiye personelinin iş sağlığı ve güvenliği konusuna bakışı ele alınmaktadır. Personelin kendi sorumluluklarını içeren mevzuatları ne kadar takip ettikleri ve ne kadar uygulamaya aktarabildikleri sorgulanmaktadır. Ayrıca, alan çalışmalarında iş sağlığı ve güvenliğinin uygulanabilirliği yönüyle dikkat edilmesi gereken konular irdelenmektedir. Bu kapsamda Ankara İlinde seçilen şantiye alanında gözlem yapılarak personel ve yöneticilerle görüşülmüştür. Peyzaj uygulama hizmetlerinde görev yapan personelin konuyla ilgili görüşleri alınarak kendi sorumluluklarını içeren mevzuatları ne kadar takip ettikleri ve ne kadar hayata geçirdikleri sorgulanmıştır. Peyzaj uygulama hizmetlerinde iş sağlığı ve güvenliğinin uygulanabilirliği yönünden dikkat edilmesi gerekenler bakımından çözüm önerileri geliştirilmiş ve çalışma sonucunda ortaya çıkan bilgiler ışığında geleceğe yönelik önerilerde bulunulmuştur.
Düzce Orman Ürünleri Sanayi Çalışanlarında Yorgunluk ve Yorgunluğu Etkileyen Etmenlerin İncelenmesi
Authors: ÇİL Muhammet , GEDİK Tarık , SEVİM KORKUT Derya
Published: April 2021

İş gücü yoğun bir sektör olan orman ürünleri sanayi sektöründe çalışanlar, çalışma ortamının çevresel ve fiziksel faktörlerinden etkilenmektedirler. Bu çalışmada, Düzce ilinde faaliyette bulunan orman ürünleri sanayi işyerlerinde fiziksel, zihinsel ve çevresel faktörler ile vücut duruşunun çalışanların yorgunluk düzeyleri üzerindeki etkilerinin belirlenmesi amaçlanmıştır. Çalışma amacını gerçekleştirmek için 2019 yılı Düzce Ticaret ve Sanayi Odasına kayıtlı 10 ve daha fazla çalışanı olan 196 işletmede 5459 çalışan, çalışmanın evrenini oluşturmuştur. 2019 ve 2020 yıllarındaki Covid-19 pandemisinin olumsuzlukları nedeniyle %95 güven düzeyi, %6,75 hata oranında 203 çalışana ulaşılabilmiştir. Çalışmada araştırmacılar tarafından geliştirilen anket formu kullanılmıştır. Çalışanların yorgunluk düzeyleri Krupp ve arkadaşları tarafından geliştirilen “Yorgunluk Şiddet Ölçeği” ile belirlenmiştir. Yapılan istatistiksel değerlendirmeler sonucunda katılımcıların %20,1’inin işten kaynaklı olarak yorgunluk yaşamadıkları, %63,3’ünün işten kaynaklı olarak yorgunluk yaşadıkları ve %16,6’sının da işten kaynaklı olarak kronik yorgunluk yaşadıkları belirlenmiştir. Katılımcıların iş esnasında taşınan ağırlığın fazla olmasından kaynaklı sorunlar yaşadığı ve çalışma ortamında bulunan çevresel faktörlerden en fazla gürültü, toz ve sıcaklık/soğukluktan kaynaklı sorunlar yaşadığı belirlenmiştir.
Determination of Combustion Properties of Heat Treated Wood Materials
Authors: ÖZCAN Cemal , GÜNDÜZ Gökhan
Published: April 2021

Studies on heat-treated wood are mostly focused on physical and mechanical properties. There is no sufficient study on combustion properties of heat-treated wooden material. In this study, combustion properties of heat-treated wooden material were determined. According to results of combustion, mass reduction in heat-treated wooden material less than non-heat-treated wood material. Temperature values of the heat-treated wooden material are higher than control samples. During combustion test, also, it was noticed that the amount of released gases such as carbon monoxide (CO), nitrogen oxide (NO) and oxygen (O2) values in heat-treated wooden material are higher than control ones in general.
Etkili Mikroorganizmaların Tüplü Toros Sediri (Cedrus libani A. Rich.) Fidanlarının Morfolojik Özelliklerine Etkisi
Authors: AYAN Sezgin , ÇALIŞKAN Ebru , ÖZEL Halil Barış , YER ÇELİK Esra Nurten , GÜLSEVEN Orhan , YILMAZ Ergin
Published: April 2021

Bu çalışmada; Etkili mikroorganizmaların (EM) tüplü 2+0 yaşlı Toros sediri (Cedrus libani A. Rich.) fidanlarının bazı morfolojik karakterleri üzerine etkisi belirlenmeye çalışılmıştır. Çalışmada; EM-1, EM-A (%30, %60, %90 dozlarında), EM-5 ve EM-Gold (%10, %20 ve %30 dozlarında) çeşitleri kullanılmıştır. Uygulamalar iki farklı zamanda gerçekleştirilmiştir. Birinci uygulama vejetasyon dönemi öncesi Nisan ayında; İkinci uygulama ise bitkilerin büyümesinin en aktif olduğu vejetasyon dönemi içinde Haziran ayında tesadüf parselleri deneme desenine göre üç tekerrürlü olarak gerçekleştirilmiştir. Uygulamalardan bir ay sonra işlemler tekrarlanmıştır. Fidanlara ait morfolojik ölçümler ikinci vejetasyon dönemi sonunda laboratuvar ortamında gerçekleştirilmiştir. Çalışma sonucunda elde edilen bulgulara göre; EM’lar, Toros sediri fidanlarının bazı morfolojik karakterleri üzerinde kontrol fidanlarına göre olumlu yönde farklılığa sebebiyet verdiği tespit edilmiştir. EM uygulamalarının orta ve yüksek dozlarının kök boğazı çapı (KBÇ), gövde taze ağırlığı (GTA), fidan taze ağırlığı (FTA), kuru kök yüzdesi (%KKök) ve gürbüzlük indisi (Gİ) karakterleri üzerinde olumlu etkisi tespit edilmiştir. Ayrıca, EM uygulamasının zamanı açısından vejetasyon dönemi içinde yapılan aplikasyonun KBÇ ve %KKök üzerinde olumlu etkisi saptanmıştır. Çalışma sonuçları ışığında; EM’ların Toros sediri fidanı yetiştiriciliğinde fidan kalitesini arttırabileceği ve Toros sediri ile yapılan ağaçlandırmalar açısından da adaptasyon yeteneği yüksek fidan eldesine katkı sağlayabileceği kanaatine varılmıştır.
DESCONSTRUINDO A LÓGICA DA ESCOLA SEM PARTIDO: glosas críticas
Authors: Hermida Jorge Fernando , De Souza Lira Jailton
Published: April 2021

Este ensaio versa sobre os fundamentos políticos e pedagógicos da proposta do movimento Escola sem Partido (ESP). Apresenta uma série de glosas críticas sobre um dos temas educacionais mais relevantes dos últimos tempos, as quais representam o ponto de vista crítico dos autores, mas também de amplos setores educacionais e sociais, defensores da escola pública e da democracia. Ancorado nos fundamentos teóricos e metodológicos da Pedagogia Histórico-crítica e do materialismo histórico e dialético, o ensaio conclui que o Escola sem Partido se constitui em um movimento autoritário, articulado com o movimento fascista internacional e com os setores políticos e econômicos mais reacionários da sociedade. Suas propostas representam o violento esforço do sistema capitalista em manter o seu processo de acumulação e concentração da riqueza, ainda que precise utilizar recursos que minam o Estado democrático de Direito liberal e as limitadas conquistas decorrentes da ampliação dos espaços de democratização formal pós Constituição de 1988.
Weight control intentions and mental health among Canadian adolescents: a gender-based analysis of students in the COMPASS study
Authors: Doan Natalie , Romano Isabella , Butler Alexandra , Laxer Rachel E. , Patte Karen A. , Leatherdale Scott T.
Published: April 2021

Introduction

Little is known about gender differences in associations between weight control intentions and mental health in adolescents. Our objective was to examine these associations in a large sample of adolescent girls and boys.

Methods

Using data from Year 6 (2017–18) of the COMPASS study (n = 57 324), we performed a series of multivariable linear regressions to examine whether weight control intentions (gain, lose, stay the same, no intention) were associated with depression, anxiety and self-concept, while adjusting for relevant covariates including body mass index. Models were stratified by self-reported gender.

Results

Compared to those with no intentions, girls who intended to lose weight reported higher symptoms of depression (B = 0.52, p $lt; 0.001) and anxiety (B = 0.41, p $lt; 0.001) and poorer self-concept (B = 2.06, p $lt; 0.001). Girls who intended to gain weight also reported higher symptoms of depression (B = 0.54, p $lt; 0.001), anxiety (B = 0.50, p $lt; 0.001) and self-concept (B = 1.25, p $lt; 0.001). Boys who intended to lose weight reported greater symptoms of depression (B = 0.26, p $lt; 0.001) and anxiety (B = 0.33, p $lt; 0.001) and poor self-concept (B = 1.10, p $lt; 0.001). In boys, weight-gain intentions were associated with greater symptoms of anxiety (B = 0.17, p $lt; 0.05), but not depression or self-concept.

Conclusion

Intentions to gain or lose weight were associated with symptoms of mental disorder and poor self-concept in our large sample of adolescents, and these relationships differed in boys and girls. These findings have important implications for school-based programs promoting healthy weight and body image.
Associations Between Physical Effort and DNA Methylation in the Promotor Region of the Dopamine Transporter Gene (DAT1)
Authors: Michałowska-Sawczyn Monika , Grzywacz Anna , Masiak Jolanta , Chmielowiec Krzysztof , Chmielowiec Jolanta , Chycki Jakub , Maculewicz Ewelina , Cięszczyk Paweł
Published: April 2021

The purpose of this study was to investigate the association between physical effort and DNA methylation in the promoter region of the dopamine transporter gene (DAT1). The research group included 100 athletes (mean age = 22.88, SD = 6.35), whereas the control group were 239 healthy male volunteers matched for age (mean age = 21.69, SD = 3.39). Both, the control and the research group, included individuals with Caucasian origin from the same region of Poland. DNA was extracted from peripheral blood leukocytes using a DNA isolation kit (A&A Biotechnology, Gdynia, Poland). Bisulfite modification of 250 ng DNA was performed using the EZ DNA Methylation Kit (Zymo Research, Orange, CA, USA), according to manufacturer's instructions. The methylation-specific PCR assay was carried out in a Mastercycler epgradient S (Eppendorf, Germany). We observed that the level of general methylation of the CpG island was similar for both groups. Further exploration of individual CpG sites allowed to notice that there were significant differences in methylation status in specific positions. Nonetheless, there was no rule that would indicate either higher or lower methylation of individual sites, four of them were methylated at a higher level (positions 1, 4, 5, 7, 8, 9, 10, 11, 12, 13, 16, 17, 18, 23, 25, 26, 27, 29 and 30), while one showed an inverse trend (position 3). More precise analysis with the usage of Bonferroni correction for multiple tests indicated that differences in CpG site methylation were mainly increased in several positions and decreased in position 3.
The Impact of Coronary Artery Calcification on Long-Term Cardiovascular Outcomes
Authors: Mitra Noémi , Gerculy Renáta , Szabó Evelin , Opincariu Diana , Chițu Monica , Benedek Imre
Published: April 2021

Decades of research and experimental studies have investigated various strategies to prevent acute coronary events. However, significantly efficient preventive methods have not been developed and still remains a challenge to determine if a coronary atherosclerotic plaque will become vulnerable and unstable. This review aims to assess the significance of plaque vulnerability markers, more precisely the role of spotty calcifications in the development of major cardiac events, given that coronary calcification is a hallmark of atherosclerosis. Recent studies have suggested that microcalcifications, spotty calcifications, and the presence of the napkin-ring sign are predictive vulnerable plaque features, and their presence may cause plaque instability.
Together We Know More than We Do Alone:
Authors: Fentz Christine
Published: April 2021

The author curated keðja aarhus Questioning Agendas, a part of the Nordic-Baltic keðja encounter for dance professionals – this one taking place in Aarhus, September 2011. The focus of the encounter was to challenge the known formats of conferences and gatherings, as well as the awareness of the dance environment regarding our surrounding society: How to create formats, which facilitate dynamic structure for exchanging and sharing knowledge? What formats can keep us alert so that we continue questioning not only how we do what we do, but also why we do it? If we accept the idea that together we know more than alone, then the arts sector would be the best place to develop the learning structures for and of the future.
Does an Alteration in Nociceptive Response to Mineral Components of Dental Composites Involve Changes in Oxidative Status? A Brief Report
Authors: Arsenijevic Natalija , Milenkovic Jovana , Milanovic Pavle , Arnaut Aleksandra , Jovanovic Milica , Velickovic Stefan , Scepanovic Radomir , Selakovic Dragica
Published: April 2021

Since that use of bioactive mineral components of dental composites have been accompanied with various toxicities, including neurotoxicity, the aim of the study was to examine the effect of chronic application of hydroxyapatite, tricalcium phosphate and amorphous calcium phosphate in nanoparticles (nHA, nTCP, nACP) to parameters of sensitivity to thermal pain stimuli. Although the systemic toxicity of those compounds is frequently attributed to an oxidative damage, we also decided to examine the potential effects of Filipendula ulmaria extract on nociception alterations induced by the nano-sized mineral components of dental composites. Forty-two Wistar albino rats were divided into control and six experimental (equal) groups that orally received either nHA, nTCP, nACP alone, or simultaneously with FU extract for 30 days. Nociceptive alterations were quantified in the hot plate and tail flick test. The chronic administration of nHA and nACP resulted in significant increase in reactivity to thermal stimulus, with no significant change observed in nTCP group when compared to the control in the hot plate test, while simultaneous application of FU extract prevented any significant alteration of time to respond. The reaction time in the tail flick test for all three groups that received only nano calcium phosphates was reduced, with no changes in the groups treated with FU extract. The results of this study confirmed that calcium phosphates of mineral components of dental composites produced hyperalgesic effects, and this side effect were significantly attenuated by antioxidant supplementation.
PROCENA STANJA I ENERGETSKA SANACIJA VIŠESPRATNE STAMBENE ZGRADE U ULICI STANOJA STANOJEVIĆA U NOVOM SADU
Authors: Ćulibrk Biljana
Published: April 2021

Rad se sastoji iz dve celine. Prvi deo rada predstavlja teorijsko istraživački deo sa temom „Proizvodi za toplotnu izolaciju zgrada - spoljni kompozitni sistemi za toplotnu izolaciju (ETICS) na bazi mineralne vune“- EUROPIAN STANDARD EN 13500 gde je opisan pojam ETICS sistema, najbitnije osobine, principi primene i način montaže. Takođe, opisan je EN 13500 – evropski standard u kome su utvrđeni zahtevi za fabrički izrađenim ETICS proizvodima koji se isporučuju u kompletu. U drugom delu rada izvršen je vizuelni makroskopski pregled objekta, sa ciljem utvrdjivanja postojećeg stanja za višespratnu stambenu zgradu u Novom Sadu. Za objekat je uradjen proračun energetske efikasnosti. Na osnovu ovog proračuna i vizuelnog pregleda konstrukcije, date su sanacione mere koje povećavaju trajnost objekta, energetsku efikasnost, kao i njegovu usaglašenost sa Pravilnikom o energetskoj efikasnosti.
Playing Games of Dress-Up During the Italian Renaissance
Authors: Andrews Maddi
Published: April 2021

Throughout the Renaissance, people would dress sculptures of the Virgin during sacred ceremonies, adorn sculptures of the Madonna and Child with jewels, and swaddle sculptures of the infant Christ. Agostino di Giovanni’s Annunciate Virgin (1321) [Fig. 1] reflects the popular tradition of dressing sculptures in Tuscany during the Trecento and Quattrocento. Agostino di Giovanni carved the Annunciate Virgin wearing only a red underdress, as this sculpture was originally dressed in an actual fabric mantle and veil. The moveable joints in her elbows and shoulders facilitated dressing. The Virgin reflects the idealized beauty standards of the period, with full cheeks, almond-shaped eyes, a small pointed nose, and delicate rosebud lips. During the Trecento and Quattrocento, dressing sculptures were popular, and worshipers likely engaged in the act of dressing as a form of devotion. Her youthful beauty, and the fact that worshipers dressed her, raise issues of decorum, especially considering that the act of dressing implies undressing. These tensions are reflected in later accounts of priests dressing sculptures of the Virgin Mary using poles and under the supervision of pious women. Given that worshipers dressed this sculpture in actual fabric, how did the Annunciate Virgin balance humanity and divinity, thus mitigating these concerns of modesty? This research paper explores this question using the visual reconstruction of the Annunciate Virgin, which recreates the original physical and social context of the sculpture [Figs. 2 –3].

 

(clockwise from upper left) Figure 1.Annunciate Virgin by Agostino di Giovanni1321

Figure 2.Annunciate Virgin Reconstruction

Figure 3.Reconstruction
Picturing Canada
Authors: Lanziner Jessica
Published: April 2021

This project focused on gathering information relevant to photography in British North America from the period of 1839-1889.  It utilized the digitized newspapers available on the searchable Paper of Record database, beginning with Halifax, Toronto, St. Thomas, and Vancouver. The recorded information highlighted photographic service advertisements, studio location changes, photographic bookings, and new developments in photographic technology.  This research allows for insight into how and for what purposes photography was being used in this time period.  Through examining different newspapers across multiple locations, this project was able to track the speed at which news and technological developments were received in different areas. The project additionally tracked and mapped the location of artists and photography studios, in an effort to tie the movement of photographers from one city, town, or province, to one another. Several photographers were discovered to occupy the same photographic studios, passing off their studios to others, while in pursuit of a greater opportunity elsewhere. In executing this research, this project established a basis for on the archived information on early Canadian photography, and specifically, the connections between the movement of photographers.
Ecofeminism and Post-Apocalyptic Environments in Roanhorse’s Trail of Lightning
Authors: Gukert Talia
Published: April 2021

This paper examines the significance of post-apocalyptic narratives as a means of expressing deep-seated anxieties about colonialism, capitalism, and cultural erasure in Rebecca Roanhorse’s Trail of Lightning. By viewing the novel through an ecofeminist lens, I seek to illuminate and explain the political changes Roanhorse’s post-apocalyptic world, and how this new environment allows for the transformation of social and gender structures of power. The theory of ecofeminism relies upon the belief that both women and nature are equally compromised and exploited by the patriarchy, constrained by the masculine forces of colonialization and capitalism. By situating her novel in a post-apocalyptic environment, Roanhorse implies that just as the earth has asserted its power over the effects of unrestricted capitalism through the consequences of global warming, Indigenous women have similarly taken back their powers of autonomy, liberating themselves from traditional gender roles. This paper shows how the connection between women and nature is most evident in the novel’s female protagonist, Maggie, who has been able to aggressively deviate from traditional gender norms and expectations due to the apocalypse. Through this complete reversal of common gender tropes in post-apocalyptic literature, Roanhorse demonstrates that the apocalypse has proven to be instrumental in freeing women from the constraints of gender roles, advocating the ecofeminist view that cooperation between women and nature is necessary for the liberation of both.
The Guide: An Emerging Role in Participatory Theatre
Authors: Manderson Derek
Published: April 2021

As Canadian culture continues to grow an obsession with individualism in the era of the selfie, theatre has similarly found a new focus in shifting the spotlight from the stage to the audience. The result of such interests is participatory theatre, which reimagines the audience as players in a shared experience. In an evolving form of performance, audience members abandon the darkened theatre seats and the comfort of passivity in favour of agency. While thrilling, this radical shift in perspective is often accompanied by intense feelings of fear and insecurity. How can anyone be a “good” participant without knowing what to do? What if something goes wrong? To combat apprehension in would-be players, a new role has begun to appear in contemporary participatory theatre: the guide. Existing both in the reality of the performance and the world of the audience, the guide provides a safe space for participation. This role establishes the rules, and eases discomfort when necessary to ensure players can confidently contribute. By applying dramatic theory to a series of case studies, this presentation will highlight where the guide appears in contemporary Canadian theatre, and the critical function it plays in each performance’s success. Not only does it ensure that audience members embrace the attitude of a player, it allows the participant to feel comfortable enough to reflect on the purpose of their newfound activity. Ultimately, the guide will prevent the average theatregoer from dreading participation by facilitating meaningful play that is equal parts entertaining and aesthetically satisfying.
The Effect of the Immunosuppressant Drug, Tacrolimus, on Nitric Oxide Production in the Immortalized First Trimester Extra-Villous Trophoblast Cells
Authors: Coyle Kassandra
Published: April 2021

The remodeling of uterine spiral arteries and subsequent placental formation are crucial for normal growth and development of the fetus. These processes are heavily dependent on the functioning of the extra-villous trophoblast cells and their ability to invade into the maternal decidual blood vessels. Reduced trophoblast invasion and shallow spiral artery remodeling can lead to a number of gestational complications including intrauterine growth restriction (IUGR). Therapeutic intervention with low dose immunosuppressant tacrolimus was able to prevent implantation failure and IUGR in obese and diabetic mice. Treatment with tacrolimus successfully aided in spiral artery modification that was conducive to a successful pregnancy. Further, tacrolimus has shown promise in restoring trophoblast cell functioning in the immortalized first trimester HTR8/SVneo extra-villous trophoblast cells cultured under preeclampsia-like conditions in vitro. However, the mode of action of tacrolimus has yet to be elucidated. Here we attempt to uncover the mode of action of tacrolimus by examining its effects on eNOS activity within the trophoblast cells. Cells were treated with tacrolimus (10 ng/mL), L-NAME (40 nM/mL) or a combination of both and subjected to analysis by several functional assays. The data obtained in this study is suggesting that L-NAME treatment has inhibitory effects on the levels of the pPGR, pSTAT3 and NO within the HTR8/SVneo cells. The use of low-dose tacrolimus abrogated the suppressive effect of L-NAME and restored the levels of the pPGR, pSTAT3, and NO within the cells.
Transplante alogênico de medula óssea em crianças: experiência inicial do Hospital Santa Casa de Misericórdia de Belo Horizonte
Authors: Carvalhais Marina
Published: April 2021

OBJECTIVE: To report the clinical experience of a tertiary care hospital with allogeneic hematopoietic stem cell transplantation in children. METHODS: Data analysis of medical charts of the first 6 pediatric patients transplanted between April 2018 and December 2018. RESULTS: 6 patients (4 boys and 2 girls) with leukemia (5 ALL e 1 CML) received allogeneic transplants. The median age was 8 years. Donor sources were bone marrow (4 cases) and peripheral-blood stem cells (2 cases). All patients survived the first 100 days after transplantation and had a median clinical follow-up of 168 days. One patient developed acute GVHD and all patients developed at least one infection. Catheter-related bloodstream infections occurred in 66% of patients. Fever and mucositis were observed in all kids. The average length of stay at the hospital after transplantation was 38 days, 83% of the patients were admitted again due to infection or relapse. CONCLUSION: The obtained results are similar to others reported and make possible to know better all the factors that can influence the transplant success and survival in children and adolescents. However, Brazilian studies are still scarce. More studies should be encouraged, in order to increase the survive rate of our children.
Case report: congenital neurosyphilis
Authors: Nunes Tuany
Published: April 2021

OBJECTIVE: To report a case of congenital neurosyphilis with cutaneous alteration in order to complement the literature. CASE REPORT: A 26-year-old, pregnant woman, gives birth to a newborn with vesicobullous lesions on the hands and feet, consistent with plantar pemphigus. Screening for congenital syphilis showed blood VDRL of 1:512 in the newborn and 1:128 in the postpartum. In the cerebrospinal fluid, on the other hand, the exam was reagent in the ratio of 1:2, being then diagnosed as congenital neurosyphilis. CONCLUSION: The importance of physical examination in pediatrics is of great value, as it can alert us to possible diagnosis. Unfortunately syphilis is once again present in our daily lives, and we can not but trace and treat it as its correct treatment can improve the quality of life or even cure the newborn.
Biosurface processing with role in improving the osseointegration of the oral implant
Authors:   Department of Prosthesis Technology and Dental Materials, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, Bucharest, Romania, Vasilescu Vlad Gabriel , Vasilescu Elisabeta ,   Department of Materials and Environment, Faculty of Engineering, “Dunărea de Jos” University of Galați, Galați, Romania, Sîrbu Valentin ,   Implant-Prosthetic Therapy Department, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, Bucharest, Romania, Ciocan Lucian Toma ,   Department of Prosthesis Technology and Dental Materials, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, Bucharest, Romania
Published: April 2021

Introduction The osseointegration of the oral implant involves a close contact between the bone and the implant, an important feature that allows the optimal transfer of stresses from the implant to the bone. Achieving and maintaining tissue integration is ensured by a biosurface design with a role in reducing the effect of shear forces on the interface, which can stimulate osteogenesis and facilitate tissue remodelling. Numerous specialized studies describe the method of modifying the biosurface area generated by a certain topography, among them are those that attest to the role of roughness in increasing the number of cells that will adhere to a biosurface with a larger area. Methodology Research was performed in order to establish the influence of mechanical processing on the micro-roughness of the surface of the samples from the experimental bioalloy Ti10Zr. Atomic force microscopy (AFM), scanning electron microscopy (SEM) and fluorescence microscopy were used to evaluate the experimental results. Results The study presents the results on the micro-roughness profile and the values of the parameters that characterize the micro-roughness profile groups (2D and 3D) of the biosurfaces processed by grinding and very fine polishing. Aspects regarding the modification of biosurface morphology, compared to mechanical processing, acid corrosion and anodic oxidation, as well as the results regarding cellular behaviour (e.g. adhesion of osteoblasts) to experimentally processed biosurfaces are also presented. Conclusions The results of this experimental study together with those previously presented in “Controlled Changing of Implantable Bioinert Materials Biosurface “scientific paper compile a synthesis of information on the ability to modify the microtopography of the biosurface of the Ti10Zr alloy, by different ways in order to improve implant osseointegration.
Effect of digital workflow on the marginal fit of long-span implant-supported bars for kennedy ii class removable prostheses in vitro
Authors:   Department of Prosthodontics, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece, Villias Aristeidis , Papadopoulos Triantafillos ,   Department of Biomaterials, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece, Polychronakis Nikolaos ,   Department of Prosthodontics, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece, Karkazis Hercules ,   Department of Prosthodontics, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece, Polyzois Gregory ,   Department of Prosthodontics, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece
Published: April 2021

Introduction The production procedures, including impressions, introduce errors affecting the passivity of fit. A completely digital workflow is possible nowadays because of the intraoral scanners (IOS). This study aimed to evaluate the effect of the impression technique (conventional versus digital) and the screw tightening sequence on the marginal discrepancy (MD) of implant-supported bars. Methodology This laboratory study was conducted on a simulated Kennedy class II edentulous maxilla with three parallel implants in the edentulous quartile. The closed tray technique with a-silicon (CTM) and the intraoral scanning with the I-Tero™ system (IOS) were compared and three bars were manufactured from each technique. Depending on the screw tightening sequence (A11 and A17) 4 groups were created with 6 samples each. The MD was examined implementing 24 negative replicas, which were sectioned and studied under a stereomicroscope. The Horizontal Discrepancy (BHD), Vertical Discrepancy (BVD) and Conical Discrepancy (BCD) of the bar were calculated on the means of the measurements of the horizontal, the vertical and the conical MD respectively. The descriptive statistics, normality tests, one-way ANOVA (a=.05) and post-hoc Tukey’s tests were run and the graphs were draw with SPSS. Results There was a significant effect (P<.05) of the impression technique combined with the screw tightening sequence on all variables. The post-hoc Tukey’s tests revealed significant differences between all groups except from those of the same impression technique only for the BHD (P<.05). Conclusion In this study all groups resulted in marginal discrepancies. The closed tray impression technique gave better results.
Reasoning, granularity, and comparisons in students’ arguments on two organic chemistry items
Authors: Deng Jacky M. , Flynn Alison B.
Published: April 2021

In a world facing complex global challenges, citizens around the world need to be able to engage in scientific reasoning and argumentation supported by evidence. Chemistry educators can support students in developing these skills by providing opportunities to justify how and why phenomena occur, including on assessments. However, little is known about how students’ arguments vary in different content areas and how their arguments might change between tasks. In this work, we investigated the reasoning, granularity, and comparisons made in students’ arguments in organic chemistry exam questions. The first question asked them to decide and justify which of three bases could drive an acid–base equilibrium to products (Q1, N = 170). The majority of arguments exhibited relational reasoning, relied on phenomenological concepts, and explicitly compared between possible claims. We then compared the arguments from Q1 with arguments from a second question on the same final exam: deciding and justifying which of two reaction mechanisms was more plausible (Q2, N = 159). The arguments in the two questions differed in terms of their reasoning, granularity, and comparisons. We discuss how course expectations related to the two questions may have contributed to these differences, as well as how educators might use these findings to further support students’ argumentation skill development in their courses.
Molecular Polaritons Generated from Strong Coupling between CdSe Nanoplatelets and a Dielectric Optical Cavity
Authors: Qiu Liangyu , Mandal Arkajit , Morshed Ovishek , Meidenbauer Mahilet T. , Girten William , Huo Pengfei , Vamivakas A. Nickolas , Krauss Todd D.
Published: April 2021

We demonstrate the formation of CdSe nanoplatelet (NPL) exciton-polaritons in a distributed bragg reflector (DBR) cavity. The molecule-cavity hybrid system is in the strong coupling regime with an 83 meV Rabi splitting, characterized from angle-resolved reflectance and photoluminescence measurements. Mixed quantum-classical dynamics simulations are used to investigate the polariton photophysics of the hybrid system by treating the electronic and photonic degrees of freedom (DOF) quantum mechanically, and the nuclear phononic DOF classically. Our numerical simulations of the angle-resolved photoluminescence (PL) agree extremely well with the experimental data, providing a fundamental explanation of the asymmetric intensity distribution of the upper and lower polariton branches. Our results also provide mechanistic insights into the importance of phonon-assisted non-adiabatic transitions among polariton states which are reflected in the various features of the PL spectra. This work proves the feasibility of coupling nanoplatelet electronic states with the photon states of a dielectric cavity to form a hybrid system and provides a new platform for investigating cavity-mediated physical and chemical processes.
Dimeric and Trimeric Catenation of Giant Chiral [8+12] Imine Cubes Driven by Weak Supramolecular Interactions
Authors: Benke Bahiru Punja , Kirschbaum Tobias , Graf Jürgen , Mastalerz Michael
Published: April 2021

Mechanically interlocked structures, such as catenanes or rotaxanes are fascinating synthetic targets and are the basis of molecular switches and machines. Today, the vast majority of catenated structures are built upon macrocycles and only a very few examples of three?dimensional shape-persistent organic cages forming such structures are reported. However, the catenation in all these cases was based on a thermodynamically favoured π-π stacking under certain reaction conditions. Here, we present our findings that catenane formation can be driven by even less directional dispersion (Keesom) interactions of methoxy-groups during the synthesis of chiral [8+12] imine cubes, giving dimeric and also for the first time trimeric catenated organic cages. To further elucidate the underlying driving forces, twelve differently 1,4-substituted benzene dialdehydes have been reacted with a chiral triamino tribenzotriquinacene under various conditions to study whether monomeric cages or catenated cage dimers are the preferred products.
Chemoselective Electrosynthesis Using Rapid Alternating Polarity
Authors: Kawamata Yu , Hayashi Kyohei , Carlson Ethan , Shaji Shobin , Waldmann Dirk , Simmons Bryan , Edwards Jacob , Zapf Christoph , Saito Masato , Baran Phil
Published: April 2021

Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome using either reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochemistry offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using direct current (DC). In contrast, utilization of alternating current (AC) has been considered as an option to improve reaction efficiency rather than a way to achieve distinctly different reaction outcomes. Here we show how a unique type of waveform employed to deliver electric current – rapid alternating polarity (rAP) – enables control over reaction outcomes in the chemoselective reduction of carbonyl compounds, one of the most widely used reaction manifolds. The reactivity observed cannot be recapitulated using DC electrolysis or chemical reagents. The synthetic value brought by this new method for controlling chemoselectivity is vividly demonstrated in the context of classical reactivity problems such as chiral auxiliary removal and cutting-edge medicinal chemistry topics such as the synthesis of PROTACs.
Radical Trifluoroacetylation of Alkenes Triggered by a Visible-Light-Promoted C−O Bond Fragmentation of Trifluoroacetic Anhydride
Authors: Zhang Kun , Rombach David , Nötel Nicolas Yannick , Jeschke Gunnar , Katayev Dmitry
Published: April 2021

Trifluoromethyl ketones are not only found in drug like substances, but are also considered as key synthons for the preparation of various fluorinated heterocyclic molecules. Access to such trifluoromethyl ketone derivatives typically requires the incorporation of the trifluoromethyl group, or a surrogate moiety, at the beginning of a multi-step synthetic sequence. However, direct trifluoroacylation of alkenes could potentially provide a highly efficient and straightforward method for the synthesis of a,b-unsaturated trifluoromethyl ketones. Here we report a mild and operationally simple trifluoroacylation strategy of olefines, that utilizes trifluoroacetic anhydride as a low-cost and readily available reagent. This light-mediated process is fundamentally different from conventional methodologies and occurs through an trifluoroacyl radical mechanism promoted by a photocatalyst. Beyond simple alkenes, this method allows for chemo- and regioselective functionalization of small-molecule drugs and common pharmacophores.
Glasbena ustvarjalnost v osnovnošolskih učnih načrtih za glasbeno vzgojo v Črni gori in Sloveniji / Musical Creativity in Primary School Programmes for Music Education in Montenegro and Slovenia
Authors: Martinović Bogojević Jelena
Published: April 2021

Encouraging musical creativity in primary schools in Montenegro and Slovenia is determined by the course programs for music education, according to which music teaching in two countries is realised through three musical activities: performing, listening and creating. The similarities between the two primary education systems are characterised by the nine-year duration of primary school, which is divided into three threeyear cycles. Programme for the course Music Culture in Montenegro, dating from 2003, has been developed in collaboration with Slovenian experts. Thus, creation, as an activity, was clearly defined and has been represented in all the revised and new programs that followed. The aim of this paper was to analyse the representation of creation as an activity through which some of the important goals and learning outcomes are achieved in both general primary education systems. The obtained results show that this activity is more concretely represented in the Slovenian programme, and that a higher level of systematicity in its definition has been achieved. Comparative analysis can also serve as a guideline for future improving the programmes and a clearer definition of what is meant by musical creativity in the teaching of music in primary schools of two educational systems.
The Philanthropic Activities During Conflict: The Case Study of the Expatriate Syrian Business Community
Authors: CHANG Ching-an
Published: April 2021

This paper analyzes the ways in which the expatriate Syrian business community engages in philanthropic activities to provide help to its fellow countrymen in host countries. Why and how did this group of people, after experiencing the brutal war and losing their assets and families, decide to provide a giving hand to others after relocations? And why did some others not? The mainstream media and reports usually describe the refugees as aid receivers who are disadvantaged or resourceless. However, from the case of the expatriate Syrian businesspeople who fled from Syria to its neighboring countries due to the conflict back home, there are various groups of Syrian philanthropic organizations funded by those businesspeople to give help and aid to other Syrians in the host countries. Their philanthropic aid is not limited to material goods, but also includes religious courses, education, and employee training. The paper argues that although refugees are usually considered to live in a poor or weaker position, the economically strong members (mostly businesspeople) among them can bring positive effects to the difficult humanitarian situations.
THE TOURISM DEVELOPMENT THROUGH CBT IN PONGGOK VILLAGE
Authors: Pugara Ade , Pradana Brian
Published: April 2021

Community-based tourism (CBT) is the most popular approaches in tourism development. The main principle of CBT is giving access to the community in tourism management and development equally. Furthermore, the main goal of CBT is creating community empowerment in tourism. Therefore, the community has competitive advantages to enhance tourism quality and keep it sustain (Hausler and Strasdas, 2003).

.In 2015 Ponggok received the village Annual Budget (Dana Desa) from the central government. Through that budget, the local government establish the Village Company (BUMDes), which is focusing on tourism development. In the tourism development, Ponggok attempt to use Pongok water springs as the main tourist attraction.. Based on these facts, this research wants to examine "is the successes of tourism development in Ponbgok Village belongs to Community-based tourism (CBT)"?. This research uses the deductive – qualitative – rationalistic method. The analytical techniques of this research are descriptive qualitative, comparative and contrast.
The tourism development of Ponggok appropriate to the principle, characteristic and dimension of community-based development. It allows the local community to control and involved in tourism management. Moreover, it attracts community empowerment and shares the benefit of tourism development to direct and indirect actors. In the current situation, all people have a job, and the number of poverty can be decreased significantly
A INTERPRETAÇÃO DA PROVA ILÍCITA COMO GARANTIA PROCESSUAL PENAL NA SUPREMA CORTE DOS ESTADOS UNIDOS, DE WEEKS (1914) A HERING (2013): BREVES APONTAMENTOS SOBRE A CONVERGÊNCIA AXIOLÓGICA, OU NÃO, COM A PROVA ILÍCITA NO BRASIL
Authors: Duarte Evandro Piza , Silva Thales Cassiano
Published: April 2021

RESUMOO texto tem por objetivo destacar as distinções do lugar ocupado pela doutrina da exclusão da prova ilícita nos Estados Unidos (EUA) em relação ao sistema constitucional brasileiro. Analisa a construção da doutrina de exclusão de provas ilícitas no sistema jurídico constitucional norte-americano a partir dos argumentos apresentados pela Suprema Corte. O período considerado compreende desde a criação da exclusionary rule (Weeks v. United States - 1914), passando pelo seu reconhecimento como regra constitucional obrigatória aos estados (Wolf v. Colorado e Mapp v. Ohio), até a decisão que provoca sua desconstitucionalização (Calandra v. United States - 1974) e, por fim, os precedentes que situam de forma preocupante o atual contexto de aplicação da regra (Hudson v. United States - 2006 - e Herring v. United States - 2009). O texto destaca porque a trajetória interpretativa de desconstitucionalização americana não autoriza a apropriação acrítica dessa peculiar lógica constitucional por parte da doutrina brasileira que pretende a relativização da prova ilícita. Ao invés disso, sugere como a importação dos argumentos configura, de fato, uma criação problemática que viola os padrões argumentativos norte-americanos e, especialmente, as garantias formais do sistema jurídico constitucional brasileiro.