bluuebunny/crossref_metadata_2025 huggingface dataset:
Quercetin Inhibits Rat Epidural Fibrosis by Regulating the Biological Behavior of Fibroblasts
Authors: Cao Yile , Chen Hui , Fan Zhehao , Sun Yu
Published: June 2021

Objective: This study attempted to investigate the effects of quercetin on postoperative fibrosis in the epidural as well as any potentially relevant signaling pathways.Methods: The effect of quercetin on reducing epidural fibrosis was confirmed via histological staining and immunohistochemical analysis in vivo. Accordingly, cell counting kit-8 (CCK-8), Western blot analysis, immunofluorescence and Eedu staining, TUNEL staining and transmission electron microscopy were used to detect the effects of quercetin on the proliferation and apoptosis of fibroblasts and explore the possible signal transduction pathway.Results: HE staining and Masson staining showed that quercetin could reduce the number of fibroblasts and collagen content. Moreover, LC3 immunohistochemical staining demonstrated that quercetin could induce autophagy, while CCK-8 showed that quercetin inhibited fibroblast viability in a concentration and time-dependent manner. The results of Edu staining, TUNEL staining and Western blot illustrated that quercetin could inhibit the proliferation and promote the apoptosis of fibroblasts. Additionally, immunofluorescence showed that quercetin could inhibit the migration of fibroblasts and reduce collagen content. LC3 immunofluorescence staining, Western blot and transmission electron microscopy demonstrated that quercetin could induce autophagy. Furthermore, following intervention with autophagy inhibitor 3-MA, quercetin was suggested to affect the proliferation and apoptosis of fibroblasts via autophagy, possibly through the PI3K / Akt / mTOR signaling pathway.Conclusion: Quercetin can regulate fibroblast proliferation, apoptosis, migration and other biological behaviors through autophagy, thereby preventing epidural fibrosis. The specific corresponding pathway may be the PI3K / Akt / mTOR signaling pathway.
Five-year survival in patients with Glioblastoma is overestimated in registry data - A nationwide population-based Swedish survey during 1958 - 1999
Authors: Milos Peter , Visse Edward , Al-Shudifat Abdulrahman , Siesjö Peter
Published: June 2021

Background Some glioblastoma (GBM) patients survive more than five years with hitherto no clearly established epidemiological or molecular causes. Since varying rates of GBM five-year survival have been reported our aim was to assess the true prevalence of five-year survivors in Sweden from 1958 to 1999, before the introduction of concomitant temozolomide treatment.Methods After screening the Swedish Cancer Registry and the Cause of Death Register 736 out of 12765 patients with high-grade glioma were defined as five-year survivors. The full text pathology report was reviewed in 585 patients. Data on epidemiology and treatment were retrieved from the medical records of 556 patients.Results 77 five-year survivors with primary GBM were identified which corresponded to 0.60 % of the initial population. During 1990 to 1999 GBM five-year survival was 0. 90%. Younger age, Karnofsky score > 70 and non-eloquent tumour location were found in most but not all five-year survivors.Conclusion GBM five-year survival was exceedingly rare in Sweden until 2004, comprising less than 1 % of registered HGGs. Relying on registry data without reviewing the pathology report will overestimate the accurate number of five-year survivors. To our knowledge, this is the only nationwide population-based study of five-year survival in GBM patients.
Self-Directed Passive Aggressive Behaviour as an Essential Component of Depression: Findings from two observational studies
Authors: Schanz Christian Günter , Equit Monika , Schäfer Sarah Katharina , Michael Tanja
Published: June 2021

Background Self-directed passive aggressive behaviour is defined as self-harm by inactivity or omission. Based on the self-control model of depression suggesting depressive symptoms to derive from distorted self-monitoring, self-evaluation and reduced self-reward as well as increased self-punishment and reduced self-reward, a relationship between self-directed passive aggressive behaviour and depression had been assumed. First evidence for this notion derives form a recent study, demonstrating a correlation between self-directed passive aggressive behaviour and depressive symptoms. However, it remains unclear if patients with depressive disorders report more self-directed passive aggressive behaviour than patients without depressive disorders and if self-directed passive aggression mediates the associations between distorted self-monitoring and self-evaluation with depressive symptoms.Methods Study 1 compared self-directed passive aggressive behaviour levels between 220 psychotherapy outpatients with (n = 140; 67.9% female; Mage = 40.0) and without (n = 80; 65.0% female; Mage = 36.2) depressive disorders. Diagnoses were made based on the Structured Clinical Interview for DSM IV. Study 2 examined self-directed passive aggressive behaviour as mediator of the relationship between distorted self-monitoring and self-evaluation and depressive symptoms in 200 Psychology students.Results Compared to outpatients without depressive disorders, outpatients with depressive disorder reported significantly more self-directed passive aggression (d = 0.51). Furthermore, Study 2 verified self-directed passive aggressive behaviour as partial mediator of the relationship between dysfunctional attitudes (abcs = .22, 95%-CI = .14 − .31), attributional style (abcs = .20, 95%-CI = .13 − .27), ruminative response style (abcs = .15, 95%-CI = .09 − .21) and depressive symptoms.Conclusion Self-directed passive aggressive behaviour partially mediates the association between distorted self-monitoring and self-evaluation with depressive symptoms and might represent a core component of depressive disorders.Trial registration: Both studies were preregistered at the German Clinical Trials Register (DRKS000140051 and DRKS000190201).
Complete sputum smear monitoring among adults with pulmonary tuberculosis in central Uganda: evidence from a retrospective cohort study
Authors: Adrawa Norbert , Okoboi Stephen , Komuhangi Alimah , Izudi Jonathan , Nsubuga Ronald
Published: June 2021

Background: People with bacteriologically confirmed pulmonary tuberculosis require sputum smear monitoring at 2, 5, and 6 months to establish treatment outcomes. However, there is limited information about sputum smear monitoring in Uganda, similar to other developing countries. We examined factors associated with complete sputum smear monitoring among persons with bacteriologically confirmed pulmonary TB aged ≥15 years in central Uganda.Methods: We retrospectively reviewed and abstracted data for persons with bacteriologically confirmed pulmonary TB initiated on treatment between January 2017 and December 2019 across 11 large TB units in Masaka district in central Uganda. Complete sputum smear monitoring was measured as the receipt of three sputum smear microscopy tests at 2, 5, and 6 months of TB treatment. The data were summarized descriptively and the differences in the outcome with independent variables were examined using tests of statistical significance. The factors independently associated with the outcome were established using the modified Poisson regression analysis with robust standard errors, reported as adjusted risk ratio (aRR) along with the 95% confidence interval (CI). Results: A total of 416 participants were enrolled, with a mean age of 37.3 ±12.9 years. Of the participants, 290 (69.7) were males, 269 (64.7) were rural residents, and 128 (30.8%) had complete sputum smear monitoring. Urban residence (aRR, 1.45; 95% CI, 1.12-1.90), treatment under the community-based directly observed therapy short-course strategy (DOTS) (aRR, 1.91; 95% CI, 1.25–2.92), and TB and human immunodeficiency virus (TB/HIV) comorbidity (aRR 0.45, 95% CI 0.30–0.68) were associated with complete sputum smear monitoring. Conclusions: We observed a low magnitude of complete sputum smear monitoring among persons with bacteriologically confirmed pulmonary TB aged ≥15 years in central Uganda. Urban residence and treatment under community-based DOTS are associated with a higher likelihood of complete sputum smear monitoring while TB/HIV co-infection is associated with a lower likelihood of complete sputum smear monitoring. At rural health facilities, there is a need to develop strategies to enhance the performance of sputum smear monitoring. Additionally, TB/HIV collaboration and the implementation of community-based DOTS should be strengthened to increase the performance of sputum smear monitoring.
Exploring the Missing Heritability in Subjects With Hearing Loss, Enlarged Vestibular Aqueducts, and A Single or No Pathogenic SLC26A4 Variant
Authors: Smits Jeroen , de Bruijn Suzanne E. , Lanting Cornelis P. , Oostrik Jaap , O’Gorman Luke , Mantere Tuomo , Cremers Frans P. M. , Roosing Susanne , Yntema Helger G. , de Vrieze Erik , Derks Ronny , Hoischen Alexander , Pegge Sjoert A.H. , Neveling Kornelia , Pennings Ronald J.E. , Kremer Hannie
Published: June 2021

Pathogenic variants in SLC26A4 have been associated with autosomal recessive hearing loss (arHL) and a unilateral or bilateral enlarged vestibular aqueduct (EVA). SLC26A4 is the second most frequently mutated gene in arHL. Despite the strong genotype-phenotype correlation, a significant part of SLC26A4 cases remains genetically unresolved. In this study, we investigated a cohort of 28 Dutch index cases diagnosed with HL in combination with an EVA but without (M0) or with a single (M1) pathogenic variant in SLC26A4. To explore the missing heritability, short- and long-read whole genome sequencing and optical genome mapping were performed. We found a previously described EVA-associated haplotype (Caucasian EVA (CEVA)) to be significantly enriched in our M1 patient cohort. The haplotype was also present in two M0 cases. Despite extensive genetic analyses, we were not able to prioritize any of the variants present within the haplotype as the likely pathogenic defect, and therefore additional analyses addressing the defect(s) at the RNA, protein, or epigenetic level are required. Whole genome sequencing also revealed splice-altering SLC26A4 variants in two M1 cases, which are now genetically explained, but no deep-intronic or copy number variants. With these findings, we have provided important insights that will pave the way for elucidating the missing heritability in M0 and M1 SLC26A4 cases.
Photonic RF and microwave spectral filters based on transversal filters with Kerr microcombs
Authors: Moss David
Published: June 2021

Integrated Kerr microcombs are emerging as a powerful tool as sources of multiple wavelength channels for photonic RF and microwave signal processing mainly in the context of transversal filters. They offer a compact device footprint, very high versatility, large numbers of wavelengths, and wide Nyquist bands. Here, we present our recent progress on Kerr microcomb-based photonic RF and microwave reconfigurable filters, based both on transversal filter methods and on RF to optical bandwidth scaling. We compare and contrast results achieved with wide comb spacing combs (200GHz) with more finely spaced (49GHz) microcombs. The strong potential of optical micro-combs for RF photonics applications in terms of functions and integrability is also discussed.
Comparative Performance Analysis of Lead-Free Perovskites Solar Cells by Numerical Simulation
Authors: Srivast Shristy , Singh Anand Kumar , Kumar Prashant , Pradhan Basudev
Published: June 2021

Research of lead-free perovskite based solar cells has gained speedy and growing attention with urgent intent to eliminate toxic lead in perovskite materials. The main purpose of this work is to supplement the research progress with comparative­­ analysis of different lead-free perovskite based solar cells by numerical simulation method using solar cell capacitance simulator (SCAPS-1D) software. In this work, the device simulation is carried out in the n-i-p configuration of FTO/[6,6]-Phenyl-C61-butyric acidmethyl ester (PCBM) /Perovskite layer/ Poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine(PTAA)/Au using six different lead-free perovskite materials. The impact of different perovskite materials layers including hole and electron transport layer thickness, doping concentration on solar cell performances has thoroughly been investigated and optimized. CsSnI3 based perovskite solar cell shows the highest power conversion efficiency of 28.97 % among all the lead-free perovskite based devices. This clearly indicates that it’s possible to achieve high-performance lead-free perovskite solar cells experimentally at par with lead based perovskite solar cells in future research.
The association between driving a car and retention of brain volume in Japanese older adults
Authors: Shimada Hiroyuki , Bae Seongryu , Harada Kenji , Makino Keitaro , Chiba Ippei , Katayama Osamu , Lee Sangyoon
Published: June 2021

Objective: To examine the association between driving and structural brain volume in older individuals. Methods: In this cross-sectional study, high-resolution magnetic resonance imaging was performed in 1063 older adults. We examined global brain measures, including gray and white matter volumes and subcortical volume, using the FreeSurfer program. Participants were divided into non-drivers, those who drove < 7 days a week, and every day drivers. They were further classified into a non-driving group, an active group (drove 10 km at least once a week), and a less-active group (drove 10 km less than once a week). Results: Drivers had a larger hippocampal volume than non-drivers (p = 0.048). Low-frequency drivers had a larger occipital cortex volume than non-drivers and high-frequency drivers (p = 0.007). Active drivers had larger temporal cortex volumes than non-active drivers (p = 0.020), larger cingulate cortex volumes than non-drivers and less-active drivers (p = 0.002), and larger hippocampus volumes than non-drivers (p = 0.019). A post-hoc analysis revealed no significant between-group differences in the amygdala. Conclusions: Driving was associated with diminished hippocampal brain atrophy in older adults. Active drivers with a larger life space exhibited less brain atrophy in several regions, including the temporal and cingulate cortices.
Use of Idarucizumab in Ischemic Stroke: A National Experience in a Middle Income Country and a Concise Review.
Authors: Rivillas Julián Alejandro , Akemi Arango , Hernán Bayona , Eugenia Jaramillo , Pablo Amaya
Published: June 2021

Background

Despite receiving anticoagulation for primary or secondary prevention for atrial fibrillation, new embolic events may occur. Current stroke guidelines contraindicate the use of thrombolysis if oral anticoagulants are used within 48 hours of symptom onset. Idarucizumab may be an alternative for patients receiving dabigatran with an acute stroke when alteplase is indicated. We present a series of four cases of patients who received idarucizumab in neurological emergencies in a middle-income country in Latin America.

Methods

Using the national pharmacologic surveillance data, we retrospectively collected the cases of idarucizumab used in acute stroke, including retinal thrombosis in Colombia between 2018 and 2020.

Results

Four male patients with atrial fibrillation received thrombolysis for acute stroke, and two of them received mechanical thrombectomy. No major complications during hospitalization were present. One of the patients that received combined therapy presented with hematuria; the other patient that received thrombolysis presented with groin hematoma, but none required transfusion. All had favorable mRS at discharge and 90-day follow-up.

Conclusion

The use of thrombolysis after reversal with idarucizumab in patients with ischemic stroke is safe. Our patients presented favorable mRS at discharge and 90-day follow-up. The low number of cases is related to the poor availability of idarucizumab. Only 11 hospitals in 5 cities have storage of the medication. Stronger public policies are needed to guarantee optimal stroke treatment in patients with atrial fibrillation receiving anticoagulation, including access to reversal and reperfusion therapies to reduce further disability, especially in a middle-income country such as Colombia.
Family Health on the Humanitarian Agenda of Domestic Media: History and Modernity
Authors:   Lobachevsky State University of Nizhni Novgorod, Natalia O. Avtaeva , Maria I. Dikasova ,   Lobachevsky State University of Nizhni Novgorod
Published: June 2021

Journalism as a social institution always addresses the problems and interests of society and the individual, however, in different historical periods, the humanitarian emphasis can be the leading one, but it can also be the secondary. The authors of the article systematize the data on the presence of the topic of family health in the humanitarian agenda of the domestic media of the Soviet period and the present. The study of the humanitarian agenda of the media in different historical periods seems to be an urgent research task, since it allows us to see its evolution both in the typological aspect and in the genre-thematic one. The purpose of this article is to analyze materials related to the problem of maintaining family health, including reproductive health, in domestic periodicals at different periods of its functioning. The research is based on historical and structural-functional approaches, analysis and synthesis. The method of qualitative and quantitative content analysis was used in the study and systematization of publications of domestic periodicals. The researchers also use the comparative historical method, which helped to identify the main differences and similarities in the positioning of the problem of maintaining family health in the Soviet period and now. The results of the research can be useful for journalists working in the sphere of social journalism, covering issues of preserving the institution of the family and its reproductive potential. The authors accentuate the importance of forming an optimal and effective model of the humanitarian agenda in the media. During the Soviet period, the media focused on the issues of abortion, lack of reliable contraception, diagnosis, treatment, consequences and complications of diseases of the reproductive system. In modern Russia, maternal, infant and perinatal mortality is decreasing, methods of diagnosing and treating diseases of the reproductive sphere are improving, the media are focusing on the problems of maintaining family health, responsible parenting, and the idea of family planning. Keywords: family as a social institution, family health, media agenda, humanitarian media agenda, domestic media, family reproductive health
Socio-Cultural Adaptation of Migrants and New Types of Identity
Authors:   Novosibirsk State University of Economics and Management, Elnara M. Dumnova
Published: June 2021

The article considers the problem of migrant identity transformation in the globalizing sociocultural space. Globalization has determined new social development tendencies and prospects, including the modern nomadism. International migration is caused by a set of determining factors and forms a multi-layered and multifaceted sociocultural phenomenon studied by a number of humanities. The article substantiates methodological usefulness of studying migration and its sociocultural implications within the framework of the multidisciplinary approach. The formation of the new migrant identity types is presented as a dichotomy of transnationalism and assimilation. The broadening of the lifespace due to migration practices causes replacement of the traditional national identity by new identity types, transnational identity becoming the most widespread. The uniqueness of the transnational identity lies in its universalism, ability of the agent to identify with different cultures and peoples simultaneously. Transnationalism is more characteristic for Western societies, while assimilation as a type of sociocultural adaptation typical for the countries of the East. The Eastern culture and mentality are less flexible and striving for self-preservation they assimilate foreign cultural elements, while preserving their own uniqueness and distinctiveness. A special identity type, the drifting identity, taking shape within the second generation immigrants is highlighted in the article. The socio-philosophical analysis carried out in the article makes it possible to ascertain the existence of the socio-spatial identity integrating various identity types. Keywords: migration, nomadism, identity, determinants of migration, transnationalism, assimilation, sociocultural space
Caucasian Xenoglossary in Modern Russian and Image of “Caucasian World”
Authors:   Tyumen Industrial University, Ruslan Kh. Kasimov
Published: June 2021

The Caucasus has always been of interest for Russia. Russian-Caucasian contacts are being studied in political, economic, religious and social aspects. But linguistic horizon has not got enough treatment. The Caucasian loanwords in Russian are examined as a specific semantic field – xenoglossary. The method of intentional analysis is used for its highlighting. Хenoglossary is a lexical corpus borrowed from a definite cultural area. Dictionaries of contemporary Russian language are used as a sample. All lexicon is topically divided in household, military and gastronomic spheres. Only last one has nowadays actual usage. Such situation could be explained by different ways of the Russian-Caucasian cultural contact history. The war was a form of contact with Muslim Adyghe people (Circassians). So, this can explain the borrowed military glossary from the Abkhazo-Adyghean languages into Russian. And vice versa, Georgia was annexed to the Russian Empire in peace. Borrowed Kartvelian glossary is the consequence of that fact. It is stated that the borrowing process is still in progress. The main sources of loanwords are Northwest and South Caucasian languages. It is argued that the Caucasian loanwords are being assimilated. The Caucasian loanwords reflect the objects of culture, not natural ones. The loanwords passed in Russian orally and have low usage frequency. Stylistically, these words are neutral. It indicates the fact of axiological equivalence of “Caucasian” and “Russian” cultural areas in Russian language imagination. Penetration of some Caucasian lexemes in other Slavic languages are occurred by means of Russian. Caucasian borrowings have very limited spread in West European languages. Keywords: Caucasian loanwords, Caucasian languages, xenoglossary, semantic field, language contacts
Conceptual Foundations for Designing the Content of the Regional Component of the Educational Area “Art” (The Case of “Transbaikal Studies”)
Authors:   Transbaikal State University, Margarita I. Gomboeva
Published: June 2021

The article is devoted to the analysis of conceptual (scientific) and methodological strategies for designing the content of the regional component of the educational area “Art” on the example of Transbaikal Studies. A new educational sphere “Art” has been introduced into the educational programs of Russian schools. In a multinational state, the federal law “On Education in the Russian Federation” presupposes the implementation of the national-regional component in the lessons of the integrated course “Art”. This actualizes the need for a textbook on the art of Transbaikalia, which suggests a constructive reformatting of the definition of the content of the subject, which, in our opinion, should be preceded by an analysis of the conceptualization of scientific approaches to the selection of sections of the curriculum, subject and thematic components, educational technologies that develop the creative potential of the student. In modern education, the main subject areas of art are a fairly harmonious system of knowledge, value attitudes, artistic skills that ensure the full realization of the student’s creative potential. The relevance of the introduction of new subject areas is determined by the fundamental importance of integrating school education into contemporary art and culture.The widespread use of the figurative representation of knowledge in modern conditions (visual, iconic, pictoral), technical means of creating new imagery and the problems of simulating aesthetic worlds arising in this case, the peculiarities of the cognitive development of modern students (mosaicism, fragmentation, clip-like thinking) determine their perception of art. New sources of student motivation and ways of teaching students in a distance learning environment, current trends in technology, culture and art (D. Bachman-Medic, K. Schwab) have led to fundamental changes in the modern culture of education, the activation of additional resources for the cognitive development of students. Keywords: regional component, educational area “Art”, classical theory of art, design of the content of the subject area, principles of content selection, gaining epistemological agreement, consensus of subject specificity of the course
Technocracy as the Ideology
Authors:   Samara National Research University, Aziz Sh. O Azimli
Published: June 2021

The study examines the position of a man and society in the philosophy of technology and technocracy development that were connected with the technological progress in Europe and North America in the 19th century. The issue of relations within the “man – machine” system has become a great interest among sociologists, historians, psychologists and philosophers. The study is based on methods of analysis and synthesis of scientific writings from Plato to F. Dessauer, who referred to the important role of science and technology in the society development. The technology increasing impact on people’s lives was reflected in the emergence of technocratic concepts. They reflected the vision of technological evolution modern problems and a vision of its future development. The cornerstone of the technocracy concepts was the idea of political power transition to the technocrats’ social layer. However, during the 20th century, technocrats’ categories like scientific and technological intelligentsia, plants and factories heads, scientists and engineers did not constitute a unified political power. They were invited to discuss the economic development problems, as experts, where they were adapted to the existing political regimes rather than trying to modify them. The technocratic strata of population transformation, their political views and preferences, the impact on the socio-political situation in the country had become the main topics in the respective philosophical concepts. Thus, one important issue is man’s status in a technological society, which in turn is a relevant topic for study in the 21 st century, the century of technology. Keywords: philosophy of technology, “man – machine” system, technocracy, scientific and technological progress, political power
The Concept of “Community” in the Social Ontology of J.-L.Nancy and J. Agamben
Authors:   Irkutsk State University, Evgeny A. Prokhorov
Published: June 2021

The article discusses new ontological approaches to the concept of “community” that appeared after the “ontological turn”. If ontotheology (metaphysics) in search of the foundation of the existing (society) takes the existing beyond the limits of the existing, then the new ontology (ontoheterology) based on new methodological premises asserts the difference of being, its multiplicity due to which the being is affirmed in its being. On the basis of new theoretical prerequisites, Nancy and Agamben create new concepts of “community” which are discussed in this article. For Nancy, “community” is, first of all, a shared coexistence of being, where each individual being is manifested in multiplicity. The unitary is singular and displayed in the display to the Other. In co-existence, individuals share the meaning of finite existence, but finiteness (death) is not completeness, it is an immeasurable responsibility for existence constituting a community. In constructing the ontology of the “community”, J. Agamben uses the concepts of dispositive, homo sacer, naked life, state of emergency, and messianic time. According to Agamben, modern society is in a state of emergency, where the rule and law are suspended. In this suspension, a person turns into a homo sacer, and his life turns into a vita sacra (naked life), the city becomes a camp. At the foundation of the coming community, Agamben believes that non-activity is rooted in the Messianic time, which overcoming violence and totality opens the way to a new form-life. Thus, the new concepts of the “community”, overcoming the traditional notions of society, eliminate any form of theoretical (and practical) totality, since they carry the multiple redundancy of social being. Keywords: community, being-together, singularity, dispositive, homo sacer, state of emergency
The Imperative of the Bioethical Approach to the Moral and Political Problems of the Coronacrisis COVID-19
Authors:   Birsk Branch Bashkir State University, Vladimir M. Sokolov , Andrey V. Stovba ,   Birsk Branch Bashkir State University
Published: June 2021

Mass diseases in the modern world, such as epidemics and even more pandemics pose global threats and risks to human civilization. Few infectious diseases known or emerging pose vital ethical problems as quickly and sharply as they did during the outbreak of the new form of the coronavirus COVID-19. The peculiarity of this epidemic is that the emergency situation in healthcare over a short period of time escalated into an economic and geopolitical crisis, which received one of its names “Corona Crisis 2020”. The World Health Organization has classified COVID-19 as a worldwide pandemic. At the time of writing this article, the epidemic has declined, but in the future, there is a threat of a “new wave” of infectious diseases. The moral and political dilemmas arising from the outbreak of the new coronavirus, among other problems, also actualize many bioethical considerations in developing methods and tactics for combating the epidemic. The limited capabilities of the healthcare system and medicine in the treatment of infections highlight the need for understanding bioethical approaches to many problems and challenges affecting the vital values and interests of the individual, medical workers and society as a whole. We attempt to identify and briefly analyze some aspects of the political and moral state of modern society, due to corona crisis COVID-19. A comparative analysis of existing concepts of bioethics with an emphasis on the need for adapting ethical standards and requirements for public health policies is given. We stress the importance of adhering to the principle of mutual moral responsibility of the state and the individual; the protection of socio-economic and political rights and freedoms of a person during the period of implementation long-term measures of isolation and long-term emergency situation. Keywords: coronavirus COVID-19, pandemics, bioethics, policy, health organization
The Role of Myth in Extremism: the Socio-Philosophical Analysis
Authors:   Siberian Federal University, Tatyana V. Izluchenko
Published: June 2021

This study examines myth as an ideological component of extremism. The objective is to define the role and meaning of myths in extremist activities. Extremism is a socio-cultural and political phenomenon of modern culture, expressed in actions against the foundations of the constitutional order and public security. Myths contribute to the formation of a holistic picture of the world, to the construction of an alternative social reality, and the creation of models of thinking and behavior that correspond to the goals and objectives of extremist organizations. The research methodology is based on the theories of myth by A. Losev and M. Eliade, on the phenomenological approach of P. Berger and T. Luckmann to the construction of reality, on the cognitive features proposed by A. Kruglanski, and the interpretation of deviance by J. Gilinsky. Extremist behavior is a form of deviance, expressing in the committing of non-normative actions that threaten the stability of society and activate the mechanisms of social control. Extremist thinking is the result of psychological construction, which arose on the basis of the unnatural functioning of the cognitive system. Extremist ideologies contain myths about the future ideal state and/or society, heroes, and legendary personalities, as well as eschatological myths. Essentially, these myths do not differ from the myths inherent in other types of activity and socio-cultural phenomena. However, they contribute to extremism by demonstrating acceptable and unacceptable norms of behavior as exemplified by some legendary personalities; interpretation of historical events and processes of social reality following the political goals of organizations; creation and transmission of relevant ideas and values; the formation of identity and a sense of exclusivity among extremists. Keywords: extremism, extremist organizations, ideology, myth, future state, ideal society, deviance
Modificação do fenótipo periodontal por técnica minimamente invasiva
Authors: Cruz José Henrique de Araújo , Nunes Itamar da Silva , Silva Raquel Lira Braga da , Souza Sarah Cristina de , Pereira Vinícius Augusto Carneiro , Palmeira Júlia Tavares , Minervino Santina Sayanne Leite , Ribeiro Rodrigo Alves , Rodrigues Rachel de Queiroz Ferreira , Sousa João Nilton Lopes de
Published: June 2021

Objetiva-se descrever a modificação do sorriso através da técnica de tunelização com enxerto de tecido conjuntivo no recobrimento radicular de classes I de Miller. Paciente de 24 anos de idade, gênero masculino foi referenciado ao tratamento de recessão gengival constatada no exame clínico e radiográfico no elemento 23, cuja altura de 2 mm, largura de 3mm e mucosa queratinizada de 2 mm. Na consulta, optou-se em recobri-la com enxerto de tecido subepitelial tunelizado. Foi realizada anestesia local e incisão intra-sulcular para ser possível descolar a gengiva subsequentemente. Com o tunelizador, preparou-se um túnel muco-periósteo e efetuou-se a terapia mecânica com cureta Gracey 5/6 e química com Ácido cítrico a 10% por 3 min, para viabilizar a adequação do enxerto. O enxerto de 1,5 mm de espessura foi retirado do palato em incisão linear, entre a distal do elemento 13 e mesial do elemento 16, distante 3 mm da margem gengival. O tecido foi posicionado no local da recessão e mantido por suturas. Confeccionou-se cimento cirúrgico, orientou-se em não higienizar a região e realizar bochecho com Digluconato de Clorexidina 0,12%. Um planejamento adequado associado a uma excelente técnica de execução e previsibilidade foram ferramentas fundamentais para o sucesso no recobrimento total da recessão e aumento de mucosa queratinizada.
Disfunção temporomandibular e sono: revisão integrativa de literatura
Authors: Ramos de Luccas Gabriele , Eliene Simões de Lira Cléssia , Guedes Keiliane  Pereira , Silva Lycia Wyara Oliveira , Stechman-Neto José , Castro Corrêa Camila de
Published: June 2021

Introdução: Estudos recentes apontam que existe associação entre qualidade do sono com disfunção temporomandibular (DTM), enfatizando que estas ambas alterações influenciam significantemente a qualidade de vida dos indivíduos. Objetivo: Investigar se há relação entre DTM e aspectos do sono. Método: O presente estudo foi realizado por meio de uma revisão integrativa da literatura referente às áreas de DTM e sono, especificando sobre qualidade do sono. A proposta foi realizada por meio de pesquisas na Lilacs, Pubmed, repositórios de teses, incluindo textos em português, espanhol e inglês, diretamente relacionados ao tema e sem limite nas datas de publicação. Resultados: Foram selecionados e analisados 19 artigos, cujos autores apontaram que a relação entre DTM e qualidade do sono, parâmetros polissonográficos, hábitos orais deletérios e queixas do sono. Os achados desses estudos mostraram que a má qualidade do sono pode estar relacionada à ansiedade, depressão e estresse, principalmente. Também não apresenta relação quanto os estágios do sono ou ao sexo dos participantes. Conclusão: observou-se que tanto para a população pediátrica quanto para a adulta, houve indícios de associação entre DTM e a ocorrência de bruxismo, alteração da qualidade do sono e dos parâmetros polissonográficos.
Paludal Playscapes: Wetlands as heterotopic ludic spaces
Authors: Gearey Mary
Published: June 2021

Wetlands are amongst the most biodiverse ecosystems on the planet. Globally our ability to mitigate and adapt to anthropogenic climate change is now closely tied to these paludal waterscapes. This paper uses empirical data to offer insights into how different user groups engage with, and value, wetlands recreationally. Understanding the drivers of human use, and diversity of engagement practices, in wetlands can enable the development of targeted strategies to support long-term, wide-scale wetland adaptations in response to climate change. The data highlighted that English wetlands have been purposively repositioned as ‘ludic’, wellbeing spaces, wherein wetland users are encouraged to spend time, and money, on these sites in widely different recreational ways: for tourism; family time; commemoration, creativity and, unintentionally, delinquency. Utilising the Foucauldian concept of heterotopias, this paper evidences that these wetland ludic activities enable the flourishing of other selves and support alternative imaginative possibilities of sustainable futures.
The quasilocal degrees of freedom of Yang-Mills theory
Authors: Gomes Henrique , Riello Aldo
Published: June 2021

Gauge theories possess nonlocal features that, in the presence of boundaries, inevitably lead to subtleties.
We employ geometric methods rooted in the functional geometry of the phase space of Yang-Mills theories
to: (1) characterize a basis for quasilocal degrees of freedom (dof) that is manifestly gauge-covariant also at the boundary;
(2) tame the non-additivity of the regional symplectic forms upon the gluing of regions; and to (3) discuss gauge and global charges in both Abelian and non-Abelian theories from a geometric perspective.
Naturally, our analysis leads to splitting the Yang-Mills dof into Coulombic and radiative. Coulombic dof enter the Gauss constraint and are dependent on extra boundary data (the electric flux); radiative dof are unconstrained and independent.
The inevitable non-locality of this split is identified as the source of the symplectic non-additivity, i.e. of the appearance of new dof upon the gluing of regions. Remarkably, these new dof are fully determined by the regional radiative dof only.
Finally, a direct link is drawn between this split and Dirac's dressed electron.
Kaluza-Klein spectrometry for ${\rm AdS_{3}}$ vacua
Authors: Eloy Camille
Published: June 2021

We use exceptional field theory to compute Kaluza-Klein mass spectra
around {AdS_{3}}AdS3
vacua that sit in half-maximal gauged supergravity in three dimensions.
The formalism applies to any vacuum that arises from a consistent
truncation of higher-dimensional supergravity, no matter what symmetries
are preserved. We illustrate its efficiency by computing the spectra of
{N}=(2,0)N=(2,0)
and {N}=(1,1)N=(1,1)
six-dimensional supergravities on {AdS_{3}}\times S^{3}AdS3×S3
and of type II supergravity on {AdS_{3}}\times S^{3}\times S^{3}\times S^{1}AdS3×S3×S3×S1.
The Representation of the Neurotic Mind in Mary Julia Young’s Sonnet “Anxiety”
Authors: YEMEZ Öznur
Published: June 2021

18th-century poet and novelist Mary Julia Young was a prolific writer supporting herself by writing. She remained a biographically obscure literary figure, yet her remarkable life with the experience of anxiety drew attention through her poetic discourse and narrative. Hence, having earned her living from literature, Young had to stick to the demands of the era's literary fashions. Therefore, this paper investigates the clues and signs of the author's real experience and analyses Young's sonnet "Anxiety" in terms of the representation of the neurotic mind and anxiety. The paper categorizes the type of anxiety and the subjective experience of the poetic persona as mood and disorder. The study suggests that the implied author experiences neurosis as character neurosis whereas the historical author suffers from situational neurosis. The authorial persona is afflicted with basic anxiety as the implied author and with simple anxiety as the historical author and anxiety of authorship as a female writer. The conflict between the historical author's external dilemma and the implied author's internal dilemma leads to a profound inhibition against the very act of creating, and thus, the persona ends the poem at its peak of anxiety. Considering Young as a female writer who struggled against hardships in a literary world getting more commercial each day, the paper, using the terminology of Karen Horney and Julia Kristeva, argues that the anxious mood of the poet is represented through the discourse of the poetic persona, who not only reveals her anxiety and neurosis but also the problems of the poet herself.
Roma Cumhuriyet Dönemi’nde Exilium (Sürgün)
Authors: KARAHAN Ümran Ozan
Published: June 2021

Roma hukukunda exilium, yani sürgün cumhuriyetin ilk dönemlerinde yazılı bir yasaya dayanarak uygulanmamıştır. Bununla birlikte sürgün, sanığın işlediği iddia edilen suça göre gönüllü veya zorunlu sürgün olarak uygulanmıştır. Özellikle ağır suçlamalarla yargılanan sanıklar zorunlu sürgün ile birlikte ciddi yaptırımlara maruz kalmışlardır. Vatandaşlıkları ile birlikte mal varlıklarını da kaybetmişlerdir. Ancak zamanla sanıklar yargılama sonucu ciddi neticelerden kaçınmak için daha insancıl bir uygulama olan gönüllü sürgünü tercih etmişlerdir. Bazen de sanıklar, dini kökenli olduğu düşünülen aquae et ignis interdictio ile barınma ve beslenme imkânlarından yoksun bırakılmışlardır. Bu yaptırım yargılamadan kaçan sanıklar için de uygulanmıştır. Sürgünün bir yönü de, sürgün yerinin seçimi olmuştur. Sürgün yeri, sürgünün kalıcı mı yoksa geçici mi olduğuna göre belirlenmiştir. Sürgün yerine gitmek ise başka bir problem oluşturmuştur. Sürgüne gidecek kişi, öncelikle sürgüne gideceği yerde yaşamını idame ettirebilmek için sahip olduğu servetini yanında götürebilecek şekilde planlama yapmıştır. Her şeye rağmen sürgün, Roma’nın özellikle soylu vatandaşları için önemli olmuştur. Toplumsal sınıfların olduğu Roma’da, alt sınıf mensubu sanıklar için sürgün uygulamasının varlığı bilinmemektedir.
Relación entre la distancia recorrida en el test de caminata, disnea y calidad de vida en pacientes con EPOC
Authors: Betancourt-Peña Jhonatan , Benavides-Cordoba Vicente , Muñoz-Erazo Beatriz Elena , Ávila-Valencia Juan Carlos , Assis-Reveiz Jorge Karim , Escobar-Vidal David Alejandro
Published: June 2021

La enfermedad pulmonar obstructiva crónica (EPOC) se caracteriza por diversos signos y síntomas que limitan la realización de actividades de la vida diaria y repercuten sobre la capacidad aeróbica, además de su posible influencia en la calidad de vida relacionada con la salud (CVRS). El objetivo de la presente investigación fue determinar la relación entre la capacidad aeróbica, la disnea y la calidad de vida en pacientes con EPOC que acuden a un programa de rehabilitación pulmonar (RP). Se llevó a cabo un estudio descriptivo, con diseño correlacional de corte transversal en pacientes con EPOC y con capacidad para realizar el test de caminata de los seis minutos (TC6M) y responder los cuestionarios de calidad de vida SGRQ y CRQ-SAS. Participaron 36 pacientes, de edad media 71,9±7,1, en su mayoría hombres (83,3%). Al correlacionar el TC6M y la disnea con la escala mMRC, se reportaron valores p=0,00 y r=–0,586. A su vez, se obtuvo un valor p<0,05 en el cuestionario CRQ, en los dominios emocional, fatiga y total. La distancia recorrida en el TC6M y la disnea presentan correlación con la CVRS en los dominios fatiga, ahogo y emocional del cuestionario CRQ, mientras que el cuestionario SGRQ no refleja correlaciones.
Duazary: sus logros, avances y aportes a la comunidad científica
Authors: Pérez-Anaya Oskarly , Ceballos-Ospino Guillermo Augusto
Published: June 2021

Estimados lectores en este breve escrito anunciamos nuestro más reciente logro, aunque no el primero: Duazary se ha posicionado como la primera revista en Ciencias de la Salud del caribe colombiano según la última medición de la Convocatoria para indexación de revistas científicas colombianas especializadas - Publindex 2020, por haberse clasificado, por segunda vez en su historia, en categoría B; siendo la única de esta región con dicha clasificación. Por supuesto, esto es, en gran parte, gracias a ustedes, que a veces han fungido como autores y otras como revisores garantizando la publicación de trabajos de contenido científico relevante.
Can Chest Computed Tomography Findings of Symptomatic COVID-19
Patients Upon Admission Indicate Disease Prognosis and Clinical Outcome?
Authors: Gunduz Yasemin , Karacan Alper , Karabay Oguz , Erdem Ali Fuat , Kindir Osman , Ozturk Mehmet Halil
Published: June 2021

Aim:

This study aimed to investigate whether initial chest Computed Tomography (CT)
findings of COVID-19 patients could predict clinical outcomes, prognoses, and mortality rates associated
with the infection.

Background:

Published studies on chest CT in COVID-19 infection do not go beyond describing
the characteristics of the current period. Comparative analysis of chest CT findings upon hospital
admission among patients with different clinical outcomes is scarce.

Objective:

We sought to retrospectively evaluate and compare clinical outcomes, prognoses, and
mortality rates based upon the initial chest CT findings of 198 consecutive symptomatic patients
with COVID-19 confirmed by Polymerase Chain Reaction (PCR).

Method:

Patients (N = 198) were divided into three groups according to their clinical outcomes as
follows: group 1 (n = 62) included patients discharged from the service, group 2 (n= 60) included
patients hospitalized in the intensive care unit, and group 3 (n = 76) included patients who died despite
treatment.

Results:

Predictors of poor prognosis and mortality with regard to chest CT findings included mediastinal
lymphadenopathy, pleural effusion, and pericardial effusion, and clinical characteristics of
age, dyspnea, and hypertension. The halo sign on chest CT was a good prognosis predictor in multivariate
analysis.

Conclusion:

Some CT findings, such as discharge, intensive care unit hospitalization, and death as
the worst consequence, significantly correlated with endpoints. These findings support the role of
CT imaging for potentially predicting clinical outcomes of patients with COVID-19.
The Interplay Among Epilepsy, Parkinson’s Disease and Inflammation: Revisiting the Link through Ca2+/cAMP Signalling
Authors: Bergantin Leandro B.
Published: June 2021

Background:

Robust evidence has described that Parkinson´s disease (PD) is associated
with an increased risk for developing epileptic seizures. In fact, an interplay between PD and
epilepsy has been of interest for many years. An emerging hypothesis is that inflammation could
link both diseases.

Objective:

Bearing in mind the experience of our group in the field of Ca2+/cAMP signalling pathways,
this article discussed, beyond inflammation, the role of these signalling pathways in this link
between PD and epilepsy.

Methods:

Publications involving Ca2+/cAMP signalling pathways, PD, and epilepsy (alone or combined)
were collected by searching PubMed and EMBASE.

Results:

The comprehension of the interplay between PD and epilepsy could improve the drug therapy.
In addition, a Ca2+ signalling dyshomeostasis due to Coronavirus disease 2019 (COVID-19),
an emerging and rapidly evolving situation, has been reported.

Conclusion:

Thus, this article also debated recent findings about therapeutics involving Ca2+ channel
blockers for preventing Ca2+ signalling dyshomeostasis due to COVID-19, including the correlation
among COVID-19, epilepsy, and PD.