bluuebunny/crossref_metadata_2025 huggingface dataset:
Creating Value by Differentiation: The Case of ALDI’s Sustainability Management
Authors: Korez Vide Romana
Published: February 2025

In this case study, we examine the management and the effects of sustainable practices on value creation through differentiation in the discount retailer industry. Existing research on sustainability management focuses more on its impact on value creation through cost reduction or efficiency gains. International discount retailers are evolving and growing by adapting to the global business environment's economic, demographic and technological trends. Their types of sustainable practices and the approaches to their management are gaining recognition among consumers. Using ALDI's good practice, we examine the role of strategic and operational planning, the types of sustainable practices, and their effects on creating corporate value through differentiation. The case study reveals the role of analyzing the primary and supporting activities of a company's value chain in terms of opportunities to improve sustainability management and to find new sustainable practices, focusing on those that create value for the company through differentiation or innovation. It also raises awareness of the importance of sustainable consumption and the possibilities to support it.
Model poslovnega sistema kot osnova za vzpostavitev digitalnega dvojčka
Authors: Hočevar Timotej , Krhač Andrašec Eva
Published: February 2025

V raziskavi smo naslovili problematiko razumevanja delovanja poslovnih sistemov in obvladovanja sprememb v poslovnih sistemih. Pri tem smo se osredotočili na izzive razumevanja in obvladovanja poslovnih procesov v realnem času. V teoretičnem delu raziskave smo ugotovili, da je ena od tehnologij, ki omogočajo razumevanje in obvladovanje poslovnih procesov v realnem času, tudi t.i. digitalni dvojček (»digital twin«). Zanimalo nas je, ali je mogoče uporabiti že oblikovan poslovni repositorij izbranega poslovnega sistema kot osnovo za oblikovanje digitalnega dvojčka. Zanimalo nas je, katere dodatne tehnologije so potrebne za oblikovanje in uporabo digitalnega dvojčka in katere ključne indikatorje učinkovitosti procesa je smiselno spremljati med uporabo. Nazadnje nas je zanimalo, koliko napora in časa je potrebno za oblikovanje digitalnega dvojčka in kje uporabnik naleti na ovire. Ugotovili smo, da je uporaba digitalnih dvojčkov obetavna, vendar je razvoj še v začetnih fazah. Potrebne bodo nadaljnje raziskave in aplikativni razvoj, da bo tehnologija primerna za široko uporabo v poslovnem okolju.
Ključni dejavniki uspeha digitalne transformacije
Authors: Krhač Andrašec Eva , Medved Tilen
Published: February 2025

Poglavje obravnava večdimenzionalni proces digitalne transformacije, оd umetne inteligence dо digitalnih dvojčkov in prehoda na pametne tovarne, v različnih sektorjih. Digitalna transformacija je opredeljena kot sprememba ali premik v operativnih in strateških okvirih, ki je pоtrebna zaradi hitrega napredka digitalne tehnologije. Zagovarja vsestranski pristop k temu, kako naj se digitalna tehnologija v celoti vključi na vsa področja poslovanja z radikalnim prilagajanjem organizacijskih dejavnosti in zagotavljanjem vrednosti za stranke. Ugotovili smo, da je digitalna transformacija več kot le sprejetje tehnologije, saj zahteva spremembо kulture v smeri nenehnega eksperimentiranja in odprtosti za napake. S takšnimi spremembami postane podjetje agilno, učinkovito in usmerjeno k strankam, z zmožnostjo hitrega vključevanja novih vpogledov, ki temeljijo na podatkih, v celoten proces odločanja in inoviranja. V poglavju sо s podrobnim pregledom literature in študij primerov opisani izzivi in kritični dejavniki, s katerimi se podjetja spopadajo pri digitalni transformaciji.
Przemiany funkcji wiejskiej kuchni od końca XIX do początku XXI wieku (na materiale z terenu Lubelszczyzny)
Authors: Tymochowicz Mariola
Published: February 2025

Kuchnia na wsi na przestrzeni ponad 150 lat uległa zasadniczym zamianom. Odnoszą się one zarówno do przestrzeni, jak i funkcji, jakie pełniła dla domowników. W pierwszej części tekstu opisane zostały przeobrażenia, jakim poddane zostało wnętrze lubelskiej kuchni, która pierwotnie stanowiła tylko wydzieloną część w izbie w pobliżu pieca, a od lat 20. XX wieku stała się osobnym pomieszczeniem. W dalszej części opisane zostało, jak użytkowane było to pomieszczenie i jakie pełniło i nadal pełni funkcje dla osób z niej korzystających (kulinarną, gospodarczą, wypoczynkową, higieniczną, sakralizującą, obrzędową i integrującą). Pomimo zaistniałych zmian kuchnia pozostała najbardziej sprzyjającym miejscem w domu, gdzie realizowanych jest najwięcej zadań nieodzownych dla właściwego działania rodziny.
NA PARAÍBA NASCEU MARGARIDA(S): experiências situadas e tessituras feministas rurais no Brasil
Authors: SOBREIRA DAYANE NASCIMENTO
Published: February 2025

Este artigo objetiva trazer experiências feministas das Margaridas, mulheres rurais que se inspiram em Margarida Maria Alves, sindicalista paraibana, assassinada em 1983, responsáveis pela maior ação de mulheres da América Latina: a Marcha das Margaridas. Ancoro-me na metodologia da história oral para dar destaque às falas de Margaridas paraibanas entrevistadas durante a ida à 6ª Marcha, realizada em 2019. Nos diálogos teóricos, também, com Scott (1999), Thompson (1987) e outros/as. Entendo que, em movimento, essas mulheres tecem um feminismo rural brasileiro, que se faz, portanto, em marcha, e que as minhas experiências – que partem de meu lugar situado – não se desassociam das aqui narradas.
DINÂMICAS DE UM IMPÉRIO: os marcadores da distinção na formação do clero nativo na Ásia portuguesa (séculos XVI-XVII)
Authors: SENA GOMIDE ANA PAULA
Published: February 2025

O presente trabalho busca compreender como ocorreu a formação do clero nativo na Ásia portuguesa, considerando um conjunto de parâmetros de inclusão e exclusão aplicados a esse corpo sacerdotal local, inserido na lógica imperial portuguesa entre os séculos XVI e XVII. Em um contexto de expansão católica global, a formação e a qualidade do clero local eram especialmente relevantes, ainda que a preferência pelo trabalho evangelizador e missionário recaísse predominantemente sobre os sacerdotes europeus. Pretendemos analisar como os padres nativos estiveram subordinados a categorias classificatórias que justificaram e moldaram um complexo sistema de hierarquização e distinção social entre os sacerdotes atuantes na Ásia. Esses clérigos buscaram, em diferentes momentos, estabelecer estratégias de atuação e integração no quadro político e religioso do poder português. Observa-se que, apesar das restrições e preconceitos enfrentados, os membros do clero nativo desempenharam um papel ativo diante da hegemonia do clero europeu nos processos de evangelização das populações locais.
ARTE E CULTURA: práticas de resistências na ditadura civil militar no Brasil
Authors: DA SILVA EDINEI PEREIRA
Published: February 2025

TEIXEIRA, Heloisa. Rebeldes e marginais: cultura nos anos de chumbo (1960-1970). Rio de Janeiro: Bazar do Tempo. 2024.
Seguimento do neonato de risco na perspectiva de profissionais, gestores e mães
Authors: Barbosa Ana Paula Denis , Ueno Patricia Harumi , Canedo Mayara Carolina , Marques Fernanda Ribeiro Baptista , Silveira Aline Oliveira , Luizari Marisa Rufino Ferreira , Gaiva Maria Aparecida Munhoz Gaiva , Marcheti Maria Angélica Marcheti
Published: February 2025

Objetivo: Analisar o seguimento do recém-nascido de risco na perspectiva de profissionais de saúde, gestores e mães, identificando os desafios e as estratégias adotadas para melhorar a assistência continuada. Método: Estudo descritivo de abordagem qualitativa desenvolvido em um hospital de ensino por meio de entrevistas com dois gestores, dois profissionais de saúde e nove mães de neonatos de risco, que foram submetidas à técnica de análise de conteúdo. Resultados: Os participantes reconhecem a importância de um serviço de seguimento bem organizado para os recém-nascidos de risco no hospital; no entanto, este enfrenta barreiras operacionais e de recursos humanos que resultam na descontinuidade do cuidado, como a desorganização e as dificuldades para atender à demanda. Considerações finais: O seguimento do recém-nascido de risco no ambulatório analisado necessita de organização e implementação de fluxos para o ordenamento da atenção e atendimento da demanda, além da articulação com os serviços da rede de atenção à saúde.
Az „AAA”-videójátékok magyarországi népszerűségét befolyásoló tényezők vizsgálata
Authors: Balogh Gergely , Lengyel Péter , Czine Péter
Published: February 2025

A videójáték-iparban az „AAA” (Triple-A) egy szakszó, amelyet közepes vagy nagy kiadó által
gyártott vagy forgalmazott videójátékok osztályozására használunk. Ezek a játékok jellemzően magasabb fejlesztési és marketing-költségvetéssel rendelkeznek, mint a játékok többi fajtája. Kutatásunk során arra kerestük a választ, hogy hazánkban mely tulajdonságok a legfontosabbak a felhasználók számára az „AAA”-játékok esetében. Ezzel a műfajjal kapcsolatos fogyasztói preferenciák
vizsgálatához egy nemzetközi téren elterjedt, Best–Worst Scalingként ismert preferenciaértékelő eljárást, annak „object” esetét alkalmaztuk. A következő hét szempontot tartottuk a legjelentősebbnek:
ár, folytatás, kiadó, műfaj, platform, kritikusi értékelések, felhasználói értékelések. A primer piackutatásunkban kvantitatív online kérdőíves megkérdezést alkalmaztunk, amelyben 914 fő vett részt.
A válaszadók a műfajt tartották a legfontosabb szempontnak. A második és a harmadik legfontosabb
szempontként az árat és a platformot választották, ezeket követte a folytatás megléte. A kiadó, a
felhasználói értékelések és a kritikusi értékelések voltak a három utolsó szempont a rangsorban.
A preferenciaheterogenitás vizsgálata érdekében az egyén szintű Best–Worst-értékekkel további statisztikai számításokat végeztünk. Végül a k-közép klaszterezési eljárás során kapott három klaszter
eredményeit vizsgáltuk, amelyeket korrespondenciaelemzéssel egészítettünk ki. Az első klaszterbe a
kevésbé árérzékeny, kiadóra és műfajra nem nagy hangsúlyt fektető, platformot és felhasználói értékeléseket preferáló játékosok tartoztak. A második klaszterbe az árérzékeny, folytatásokkal és platformmal nem foglalkozó, kiadót és műfajt preferáló, fiatal, főleg női válaszadók kerültek, akik
egyébként a legritkábban és a legkevesebbet költenek az ilyen típusú játékokra a három klaszter közül. A harmadik klaszterbe a folytatásokat preferáló, értékeléseket elutasító, idősebb és régóta videójátékokkal játszó férfiak tartoztak. Meg kell jegyeznünk azonban, hogy a jövőben az általunk vizsgált
preferenciák változhatnak, mivel az „AAA”-videójátékok iparága nagyon gyorsan fejlődik. Ezért a
játékosok igényeinek kielégítéséhez folyamatosan alkalmazkodnunk kell ezen a területen.
The Use of Color T2 Mapping in MRI Examination of Children with Recurrent Patellar Dislocations in the Postoperative Period
Authors: Andronnikov Evgeniy A. , Alekseeva Tatiana V. , Mikhalkina Natalia G. , Syundyukov Ayrat R. , Preobrazhenskaya Elena V.
Published: February 2025

Background. Patellar instability in childhood and adolescence may be associated with a violation of its tracking, which often leads to the development of recurrent dislocation and rapid progression of degenerative-dystrophic changes in cartilage tissue. The standard protocol of magnetic resonance imaging (MRI) at the initial biochemical stages of cartilage matrix transformation is not effective enough to assess the shape of the patella, the degree of facet development, the state of articular cartilage, and the integrity of the supporting ligaments of the patella. Quantitative relaxation time T2 during cartilage MR mapping is a noninvasive marker of cartilage degeneration, sensitive to biochemical composition and degree of tissue hydration. T2 mapping can complement the study due to its high diagnostic significance in the early stages of arthrosis development.

Objective: to assess the condition of patellar articular cartilage after stabilizing arthroscopic surgery for recurrent patellar dislocation in children using MRI with color T2 mapping.

Material and methods. The study included 22 adolescents aged 15–17 years (13 boys, 9 girls) with habitual patellar dislocation. All patients underwent stabilizing surgical treatment. Before the operation, clinical tests, X-ray examinations in three projections, ultrasound and computed tomography of knee joints were performed. Knee joint MRI before, on day 3 and 6 months after surgery was supplemented with color mapping of patellar cartilage tissue with calculation of T2 relaxation time.

Results. Local areas in the loaded areas of patellar cartilage with an average T2 relaxation time of 35.5 ms before surgery were detected in all patients. On day 3, with the correct position of the patella, the T2 relaxation time increased to 37.8 ms. After 6 months, 86.4% of patients showed a decrease, including in 73.7% of cases – up to 28.6 ms on average.

Conclusion. MRI with color T2 mapping makes it possible to assess the restoration of cartilage structure after stabilizing surgical treatment. A slowdown in the processes of chondro-degeneration and a regenerative effect are noted as early as 6 months after surgery.
Radiomics Analysis of Ultrasound Images of Peripheral Nerves in Young Patients with Type 1 Diabetes Mellitus in Comparison with Healthy Controls
Authors: Fomina, Svetlana V. , Samoilova, Iuliia G. , Pleshkov, Maksim O. , Kudlay Dmitry А. , Voronin, Еvgeniy А. , Kachanov, Dmitriy A. , Tolmachev, Ivan V. , Koshmeleva, Marina V. , Trifonova, Ekaterina I.
Published: February 2025

Background. Early diagnosis of diabetic polyneuropathy in childhood is an urgent healthcare problem. Radiomics analysis of ultrasound images is a promising diagnostic tool for assessing the morphological structure of peripheral nerves in type 1 diabetes mellitus (T1DM).

Objective: to evaluate the possibility of using radiomics analysis in the diagnosis of peripheral nerve changes based on ultrasound images in T1DM patients of young age.

Material and methods. A total of 126 ultrasound images of peripheral nerves of the upper and lower limbs in T1DM patients aged 10–17 years (n=10) and controls (n=10) (four locations, greyscale mode) were studied.

Results. Radiomics analysis revealed differences in the texture of peripheral nerves of the limbs in young T1DM patients when compared with healthy individuals.

Conclusion. The method of radiomics analysis is a promising diagnostic tool for assessing changes in peripheral nerves in children and adolescents with T1DM.
Patterns of Neck Main Arteries Morphometry and Echocardiography Data
Authors: Khalilov Maksud А. , Moshkin Andrey S. , Moshkina Lyubov V.
Published: February 2025

Objective: to compare the objective results of ultrasound imaging of neck main arteries with echocardiography data, to assess the correlation patterns between the morphological characteristics of the structures.

Material and methods. A total of 244 volunteers (who had no signs of significant hemodynamic disorders, surgical interventions on the heart and studied vessels) were examined, who underwent ultrasound imaging of the carotid arteries and echocardiography. All studies were performed using a single technique with an assessment of the diameters of common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA), vertebral arteries (VA), as well as intima-media complex (IMC). The echographic characteristics of the aortic wall, aortic and mitral valves were considered. The data obtained were grouped and subjected to statistical analysis.

Results. Based on the diagnostic data obtained by echocardiography, eight groups were formed: (1) with signs of changes in the aorta; (2) with changes at the level of the aorta and aortic valve; (3) with changes in the aorta and mitral valve; (4) with changes in the aortic and mitral valves; (5) without signs of changes in the aorta, aortic and mitral valves; (6) with changes only in the aortic valve; (7) with changes only in the mitral valve; (8) with changes only at the level of the aortic and mitral valves. When assessing the differences between pairs of groups in cases of diagnosis of structural changes in the aortic walls and valvular heart apparatus, the indicators differed slightly, more often for IMC value. There were differences for ICA diameter when comparing Groups 1 and 4. Morphometric parameters of VA in cases of diagnosed changes did not reflect significant differences. The largest CCA diameter (5.8±0.7 mm) was noted in combination with changes in the aortic wall and heart valves. The smallest CCA diameter (5.0± 0.3) mm was in Group 6. The largest ICA (4.6±0.4 mm) and ECA (3.6±0.4) diameters were with changes in the mitral valve. The smallest ICA diameter (4.1±0.4 mm) was observed with changes only in the aortic walls. The smallest values for ECA and VA diameters were 2.8 mm, combined with changes in the aortic valve only. The most pronounced differences were obtained when comparing data in the absence of significant changes in the aortic walls and heart valves for CCA, VA, and ECA IMC.

Conclusion. The presented results expand our understanding of the individual features of neck main arteries, accompanying changes in the aortic walls and valvular apparatus of the heart.
Characteristic Radiological Signs of Tumor and Tumor-Like Lesions of Maxillofacial Bone Tissue
Authors: Maliyа Khamida I. , Burova Ilona V. , Litvinenko Еlena А. , Gogua Malkhaz G. , Semochkin Maksim N. , Solovyeva Еkaterina R. , Baryshnikova Daria V. , Kurilchik Svetlana А.
Published: February 2025

This article reviews the characteristic radiological signs of tumor and tumor-like neoplasms of maxillofacial bones, their differences and diagnostic features. An overview of the methods of radiation diagnostics used to assess the structure and extent of bone tissue damage is given. The criteria that make it possible to distinguish malignant processes from benign and tumor-like formations are shown. The presented material is useful for improving the accuracy of diagnosis and choosing the optimal treatment tactics in clinical practice.
The influence of social media on the decision to boycott Israel-affiliated products among the Muslim community in Jabodetabek
Authors: Syarif Muhyiddin , Herman Sebastian
Published: February 2025

IntroductionThe recent escalation of the conflict between Israel and Palestine triggered a global solidarity movement, including Boycott campaigns against products affiliated with Israel.ObjectivesThis study aims to analyze the determinants of digitalization's influence on online boycott product buying behavior among Muslim communities in Jabodetabek (Jakarta–Bogor–Depok–Tangerang—Bekasi), the Jakarta Metropolitan Area, or Greater Jakarta. MethodThis study's hypothesis is that social media, religiosity, subjective norms, behavioral control, and attitude have a positive and significant influence on boycotting behavior. It used an online survey with a randomly selected sample of 100 respondents. To test the hypothesis, it used structural equation modeling (SEM) with partial least squares (PLS).ResultsThe results show that social media and religiosity have a positive and significant influence on boycotting attitudes, while subjective norms and behavioral control do not have a significant influence on boycotting attitudes. Boycotting attitude also has a positive and significant influence on buying behavior. The R-square value of the model is 0.763, which means that the independent variables can explain 76.3% of the variability of buying behavior. ImplicationsThis study also provides implications for marketers and policymakers to understand the factors influencing the attitude and behavior of boycotting products affiliated with Israel among Muslim communities in Jabodetabek.Originality/NoveltyThis study contributes to the literature on consumer behavior, especially in the context of boycotting products related to political and religious issues.
Homo Islamicus as an agent of socio-economic change: A study in the perspective of Surah An-Nisa
Authors: Amini Salisa , Tarigan Azhari Akmal , Syahriza Rahmi , Ismail Ismail
Published: February 2025

IntroductionThere are several challenges faced by Homo Islamicus when dealing with the conventional economic principles that often dominate economic practice today.ObjectivesThis research aims to explore the role of Homo Islamicus in creating social and economic welfare and how Islamic values can be integrated into everyday economic practices. This research focuses on the concept of Homo Islamicus as an agent of social and economic change in the context of modern society, with an emphasis on the perspective of Surah An-Nisa. MethodThe method used in this research is a qualitative analysis of the Qur'anic texts, especially Surah An-Nisa, and a literature study on the application of Islamic economic principles in a modern context. The scope of the research includes an analysis of the differences between Homo Islamicus and Homo Economicus, where Homo Islamicus is not only oriented towards material gain but also considers moral and social responsibility.ResultsThe results show that although there are challenges in applying the concept of Homo Islamicus, such as the gap between ideality and reality, this concept remains relevant as an ethical framework for building a more just and prosperous society. Homo Islamicus plays an essential role in maintaining justice in economic transactions and contributing to the welfare of society through the practice of zakat, infaq, and sadaqah.ImplicationsThe conclusion of this research confirms that sustainable social and economic welfare should be achieved. An adaptive and educative approach is needed in applying the principles of Homo Islamicus. This research recommends strengthening Islamic economic education, emphasizing social responsibility and ethics in every economic interaction.Originality/Novelty This study contributes to the body of knowledge on Homo Islamicus in the Quranic perspective as a basis for the philosophy of Islamic economics.
New Study of Board Development’ Impact on Corporate Performance with Modelling
Authors: Jeddah Chamber , Toshania Mehmetlu
Published: February 2025

Board size is an important component of corporate governance. This study selects data from 55 listed companies in the automotive industry with beta values close to 1 from 2012 to 2024 for empirical research, analyzing the relationship between board size and corporate performance, as well as the main factors influencing board size. The results show that board size is positively correlated with corporate performance, and board size is mainly influenced by environmental characteristics, firm size, development stage, and internal board structure. Based on empirical data, the maximum board size is calculated to be 11 members.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 15.02.2025 г. по 21.02.2025 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: February 2025

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19 за неделю с 15.02.2025 г. по 21.02.2025 г.
Распространение вариантов вируса SARS-COV-2, вызывающих интерес (VOI) и находящихся под наблюдением (VUM), на основе количества их геномов, депонированных в базу данных GISAID за неделю с 15 по 21 февраля 2025 г.
Authors: Дмитриева Людмила , Чумачкова Елена , Краснов Ярослав , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: February 2025

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 Omicron вызывающих интерес (VOI) и находящихся под наблюдением (VUM), геномные последовательности которых размещены в международной базе данных GISAID за неделю Распространение вариантов вируса SARS-COV-2, вызывающих интерес (VOI) и находящихся под наблюдением (VUM), на основе количества их геномов, депонированных в базу данных GISAID за неделю с 15 по 21 февраля 2025 г.
Barrio resilente: componentes de la resilencia urbana aplicables en una zona de alto riesgo sísmico, AAHH La Unión de Villa en Villa El Salvador, 2021
Authors:   , Acuña Castillo Alexandra Catherine , Ascue Portal Carla Angela
Published: February 2025

La presente investigación tiene como fin establecer los componentes de la resiliencia urbana que son aplicables en una zona de alto riesgo sísmico, enfocado en el desarrollo y empleo de nuevas tipologías de viviendas que se adapten y respondan de manera eficaz a la pronunciada pendiente que tiene el Cerro Papa en Villa el Salvador.
En la tesis se analizaron los dos primeros componentes en el área de estudio mediante el uso de instrumentos de estudio, mientras que el tercer componente es empleado para brindar una solución a la problemática que se expone.
De esta manera, con la propuesta se pretende restructurar de manera integral el barrio, con espacios habitables y zonas de esparcimiento aptas para la pendiente, mitigar los efectos de la pobreza a través de negocios, huertos comunitarios, agricultura urbana con el fin de aportar seguridad alimentaria y económica, además de generar una mixtura en los espacios residenciales aprovechando la topografía del lugar.
Legalización de cannabis recreativa: lecciones de salud pública para México
Authors: Pérez-Ferrer Carolina , Sánchez-Pájaro Andrés , Cobo-Armijo Fernanda , Pech-Puebla Daniel , López-Olmedo Nancy , Barrientos-Gutiérrez Tonatiuh
Published: February 2025

El proceso legislativo para la legalización del uso recreativo de cannabis en México se encuentra actualmente congelado, sin embargo, es factible que se reanude en un futuro cercano. Este ensayo identifica lecciones de salud pública que podrían discutirse ante una nueva propuesta de ley para el uso recreativo de cannabis en México. En este sentido, realizamos una revisión de la literatura científica para identificar estrategias de salud pública en el marco legal del uso recreativo de cannabis y las contrastamos con las provisiones incluidas en la propuesta de “Ley Federal para Regulación del Cannabis” realizada en 2021. Identificamos seis estrategias que podrían robustecer la propuesta desde un abordaje de salud pública: 1) Límites de densidad y ubicación de puntos de venta; 2) Regulación de horas de venta; 3) Aplicación de gravamen; 4) Regulación de precios; 5) Prohibir el uso de saborizantes en productos fumados y regular productos comestibles; y 6) Especificar la regulación de la presencia de contaminantes químicos y biológicos en los procedimientos de certificación.
Academic stress in university students: self-perceived levels and modulation in the relationship with pets
Authors: Simón Emilio Jesús Lizarte , Manzano María Jesús Lirola , Gijón Meriem K. , Galván María Carmen , Puerta José Gijón
Published: February 2025

Introduction: Academic stress and its reduction, often associated with early dropout rates, has become a key issue on the agenda of international higher education policies. Purpose: The research presented here addresses this problem through the analysis of the Stress Less. Take my Paws project, a dog-assisted therapy initiative implemented at the University of Granada. Specifically, the study aims to establish baseline academic stress levels in samples from the University of Extremadura (serving as the control group) and the University of Granada (where the Stress Less. Take my Paws program will be applied). Method: With a total sample size of N = 1097 (827 in the control group and 270 in the intervention group), the study administered the STAI (Trait and State Anxiety Inventory), DASS-21, and additional questions about participants' relationships with pet. The results indicate: a) the reliability of the applied tests for anxiety, stress, and depression; b) a normal distribution of scores in both the control and intervention groups (pre-intervention) and the absence of significant differences between the two groups regarding stress levels, anxiety, and depressive symptoms; and c) no significant differences between individuals who regularly interact with dogs and those who do not (significant differences were found between dog owners and owners of other types of pets). Conclusión: The relevance of these findings is discussed, highlighting the homogeneity between the control and intervention groups, which will enable various studies on the impact of the Stress Less. Take my Paws program.
Constructing multicancer risk cohorts using national data from medical helplines and secondary care
Authors: Modarres Hadi , Pipinis Dimitris , Balasubramanian Divya , Chaplin Rupert , Kynoch Scarlett , Manandhar Achut , Thandi Gusimran , Cavilla Rebecca , Hirst-Williams Emma
Published: February 2025

Identification of cohorts at higher risk of cancer can enable earlier diagnosis of the disease, which significantly improves patient outcomes. In this study, we use machine learning to predict cancer diagnosis in the next year. We select nine cancer sites with high incidence of late-stage diagnosis or worsening survival rates, and where there are currently no national screening programmes. We use National Health Service (NHS) data from medical helplines (NHS 111) and secondary care appointments from all hospitals in England. We show that features based on information captured in NHS 111 calls are among the most influential in driving predictions of a future cancer diagnosis. Our predictive models exhibit good discrimination (AUC – 0.78 – SD 0.04), ranging from 0.69 (ovarian cancer) to 0.83 (oesophageal cancer). While our predictive modelling provides patient level risk predictions, our emphasis is on constructing cohorts of patients who may be at risk of cancer rather than individual risk scores. We present an approach of constructing cohorts at higher risk of cancer based on feature importance and considering possible bias in model results. These outputs can be used to develop highly targeted case finding services, which could help increase earlier detection rates and reduce health disparities. This approach is flexible and can be tailored based on the group the intervention targets (i.e. symptomatic or asymptomatic patients) and the data available to those charged with administering the intervention.
Patterns and Predictors of Mental Workload Among Student Nurses: A Latent Profile Analysis
Authors: Gan Yanmei , Liao Tingting , Liu Lingfang , Du Yao , Guo Mingjuan , Li Gaoye
Published: February 2025

Background Intern nursing students are actually facing considerable psychological burdens, which impact their mental well-being and career progression.
Objective This study aimed to investigate the mental workload patterns of intern nursing students and identify the factors that predict these patterns.
Methods A quantitative cross-sectional study was conducted involving 302 intern nursing students from five hospitals in Guangxi, China, between November 1 and December 30, 2024. The analysis of latent profiles was performed using Mplus 8.7 software, while Pearson’s chi-squared test and logistic regression analysis were carried out using SPSS 27.0 software.
Results Three patterns of mental workload of intern nursing students were identified as “low MWL-high self-rated (n=45, 14.9%)”, “moderate MWL (n=152, 50.33%)”, and “high MWL-low self-rated (n=105, 34.77%)”.
Conclusion This study provided novel insights into the mental workload (MWL) patterns among intern nursing students and identified key predictors, including age, internship duration, coping strategies, educational level and monthly income. The findings highlighted the heterogeneity of MWL and provide evidence-based guidance for nursing administrators to identify groups of students with high mental workload and to develop targeted psychological interventions and management strategies.
Thermoring basis for thermo-gated TRPV2
Authors: Wang Guangyu
Published: February 2025

The heat-responses of the homotetrameric thermosensitive transient receptor potential vanilloid (TRPV)1–4 channels are use-dependent. The initial short heat stimulus typically alters the temperature threshold and sensitivity for the subsequent one. The precise underlying structural motifs have not been identified except for TRPV1 and TRPV3. Since the release of lipid from the active vanilloid site is necessary for the initial heat activation of TRPV1 or TRPV3, the 3D cryo-EM structures of apo rat TRPV2 with or without any lipid in different gating states were analyzed using a highly sensitive thermoring model. The results indicated that two lipids in the voltage sensor-like domain and at the vanilloid site needed to be released to achieve theoretically and experimentally matched start and end thresholds and thermosensitivities during the first and second heat sensations. Therefore, this study further elucidated the role of lipids at various sites in the use-dependent heat responses of thermosensitive TRPV1-4 channels.
Effect of rubber particle size and content on the mechanical properties of rubber-clay mixtures solidified by EICP
Authors: Ma Qiang , Li Meng , Zeng Chen , Shu Hang , Xi Lei , Tao Yue
Published: February 2025

Using the EICP technique to solidify rubber and clay mixtures as lightweight backfill is a feasible way to reduce waste tire impacts and boost rubber recycling in geotech engineering. In this study, a comprehensive laboratory investigation, including triaxial compression, oedometer, permeability, and nuclear magnetic resonance (NMR) tests, was conducted on EICP-reinforced rubber particle solidified clay (hereafter referred to as EICP-RC solidified clay) to evaluate the effects of rubber particle content and size on the mechanical behavior of the improved soil under various solidification conditions and to elucidate the solidification mechanism. The results show that although rubber particles inhibits EICP, it significantly enhances the cohesion and internal friction angle of the samples. Additionally, incorporating smaller-sized tire particles facilitated pore filling, resulting in lower compression and swelling indices and reduced permeability coefficients, making these materials suitable for use behind retaining walls and in embankment construction.
Analyzing the Role of Health Investments in Driving Economic Growth: Evidence from Rwanda
Authors: Jacques NGARUKIYE SEKANYANGE
Published: February 2025

Background
This study investigates the relationship between health investments and economic growth in Rwanda, analyzing the role of government and private health expenditures in driving economic development in Rwanda.
Methods
Using Full Modified Ordinary Least Squares (FM OLS) analysis, the research examines how factors such as health expenditure, household consumption, labor force participation, and life expectancy impact economic growth. Descriptive statistics and the Augmented Dickey-Fuller (ADF) Unit Root Test were first employed to assess key variables' stationarity, which indicated non-stationary data at original levels. The study then applied FM OLS regression analysis to explore direct effects.
Results
The results showed that health expenditure per capita had a positive impact on economic growth, with a coefficient of 0.60, suggesting that increased health spending directly boosts the economy. Household consumption expenditure also contributed significantly, with a coefficient of 0.49, highlighting the importance of consumption in driving economic activity. Additionally, labor force participation and life expectancy had positive coefficients of 0.17 each, indicating that a healthier, more engaged workforce fosters economic output. The model accounted for 99.37% of the variation in economic growth, demonstrating a robust fit, while the Durbin-Watson statistic confirmed the absence of significant autocorrelation.
Conclusion
The study concludes that health investments are crucial to Rwanda’s economic development. It recommends scaling up health investments, improving healthcare infrastructure, ensuring equitable healthcare access, and addressing income inequality. Moreover, policies aimed at increasing labor force participation and fostering economic diversification are advised to enhance growth. Public-private partnerships are also suggested to amplify the benefits of health investments.
SERS substrate based on COFs@Ag for rapid detection of pefloxacin
Authors: Chen Kun , Ma Chaoqun , Chen Guoqing , Yang Taiqun , Gao Hui , Li Lei , Hu Anqi , Cao Jun , Zheng Chenkai , Ma Longyao , Chen Zehao
Published: February 2025

The detection of pefloxacin in milk is of significant importance for food safety. Traditional methods for detecting pefloxacin often rely on techniques such as high-performance liquid chromatography (HPLC), which are complex and time-consuming. This article introduces a surface-enhanced Raman scattering (SERS) substrate based on a composite of covalent organic frameworks (COFs) and silver nanoparticles (AgNPs) for the rapid detection of pefloxacin in milk. After testing pefloxacin (PEF) in both water and milk, the detection limits were calculated to be 6.31 µg/L for water and 82 µg/L for milk, with correlation coefficients of 0.991 and 0.998, respectively. Furthermore, the average recovery rate of pefloxacin in milk ranged from 96.25–106.17%, with a relative standard deviation (RSD) of 4.32–8.88%. This work offers a simple and rapid method for detecting pefloxacin in milk.
Comparison of Streptococcus mutans adhesion to fixed orthodontic wires in different types of saliva under laboratory conditions
Authors: SheibaniNia Ahmad
Published: February 2025

Objectives: This study investigates the adhesion of Streptococcus mutans to fixed orthodontic wires in varying types of saliva under laboratory conditions, given the heightened microbial load and increased caries prevalence in patients with orthodontic appliances.
Methods and Materials: Stainless steel wires and nickel-titanium wires of the same dimensions were utilized, with six samples per group. After preparation and sterilization, the samples were immersed for two hours in artificial saliva solutions with either normal or acidic pH. Subsequently, the samples were incubated in a S. mutanssuspension. Following serial dilution and cultivation on BHI agar, the number of former colonies was counted. The results were analyzed using two-way ANOVA with a significance level at p ≤ 0.05.
Results: The adhesion rate of S. mutans to stainless steel archwires was significantly higher than that to nickel-titanium archwires in both acidic and normal saliva (p ≤ 0.05). Moreover, the adhesion rate to both archwires was lower in acidic saliva compared to normal saliva (p ≤ 0.05).
Conclusion: S. mutans exhibits a lower adhesion rate to nickel-titanium archwires compared to stainless steel archwires in both acidic and normal saliva.
Phosphorus-Doped NiFe Electrodes for Stable Alkaline Seawater Electrolysis at Industrial Current Densities: Facile Synthesis and Mechanistic Insights
Authors: Wang Wei , Ren Zhibo , Liu Peng , Zhang Chang , Wang Tao , Wang Fan , Yan Xupeng , Guo Weiqi , Wu Zhan , Wang Jinyi
Published: February 2025

Direct seawater electrolysis offers a promising route for sustainable hydrogen production, particularly in offshore applications, yet challenges such as high overpotentials at industrial current densities and chloride-induced corrosion hinder its scalability. Herein, we report a phosphorus-doped NiFe electrode (P-NiFe-NF) synthesized via a scalable electrodeposition and vapor-phase deposition approach. The optimized P-NiFe-NF electrode achieves a low oxygen evolution reaction (OER) overpotential of 282 mV at 400 mA/cm² in simulated seawater and demonstrates exceptional stability for 175 hours under continuous operation at 400 mA/cm². The incorporation of phosphorus facilitates the in situ formation of a phosphate-rich surface layer, effectively repelling chloride ions and suppressing competitive chlorine evolution. Combined with the synergistic catalytic activity of Ni and Fe, this design enables high efficiency and durability at industrial-relevant current densities. The simplicity of the fabrication process and robust performance highlight its potential for large-scale hydrogen production from seawater.
Efficacy of Cold Karman Cannulae in Reducing Pain During Office-Based Endometrial Biopsy: A Prospective Randomized Controlled Trial
Authors: Bulutlar Eralp , Uluutku Bulutlar Gizem Berfin
Published: February 2025

Objective: The study aimed to evaluate the efficacy of cold Karman cannulae, stored at -17°C, in reducing pain levels during office-based endometrial biopsy procedures.
Study Design: This prospective, randomized controlled trial was conducted between 2021 and 2022, involving 300 female patients aged 30-60, with abnormal uterine bleeding or increased endometrial thickness. Participants were randomly assigned to two groups: the experimental group, which used cold Karman cannulae (n=150), and the control group, which used room temperature cannulae (n=150). Pain levels were assessed using the Numeric Rating Scale (NRS) immediately after the procedure and ten minutes later.
Results: The mean NRS pain score was significantly lower in the cold cannula group (4.70 ± 1.278) compared to the room temperature cannula group (6.27 ± 1.089) (p<0.05). No significant complications, such as cervical damage or infection, were observed in either group. The use of cold cannulae also facilitated the easier technical performance of the biopsy due to reduced cervical resistance.
Conclusion: The application of cold Karman cannulae significantly reduces pain perception during office-based endometrial biopsy, making it a viable option for improving patient comfort and procedural efficiency. These findings support the integration of cold application techniques in gynecological procedures to enhance pain management.
Breaking out of the silo: collaborative approaches to implementing blue-green infrastructure in urban areas
Authors: Hohmann Claudia , Bieker Susanne , Truffer Bernhard
Published: February 2025

Blue-green infrastructure (BGI) represents a subtype of nature-based solutions that leverages the collective benefits of urban green spaces and urban water management for the purpose of climate change adaptation. The success of BGI as an alternative or as a complement to the current ‘gray’ urban infrastructure is, however, hampered by existing urban planning structures. Given the numerous advantages that BGI can offer, it is essential to integrate different sectors and policy domains in order to ensure its effective implementation. This represents a novel challenge in urban planning, as the responsibility for providing different parts of urban infrastructure is traditionally split across specialized departments. In order to accelerate the successful establishment of BGI through stakeholder collaboration, the infrastructure transition canvas is employed to identify and structure coordination gaps between key actors, with the objective of developing new mechanisms of collaboration. This results in four principal coordination tasks for BGI projects: (i) coordination for value creation, (ii) coordination of stakeholders with formal decision-making power, (iii) engaging stakeholders who have no formal mandate, and (iv) intermediation. In conclusion, the paper presents a synthesis of the conditions required for stakeholder collaboration that contribute to redistributing the roles and responsibilities to facilitate successful BGI implementation.
The influence of immunosuppressive action on the structure of the thymus of experimental animals during gestation
Authors:   Lugansk State Medical University named after St. Luke, A. Zakharov Aleksey , V. Vergunova Vlada ,   Lugansk State Medical University named after St. Luke
Published: February 2025

Background. The purpose of the study was to investigate changes in the morphometric parameters of the thymus of experimental animals during immunosuppression in the second week of gestation. Material and methods. The study was carried out on 24 female white laboratory rats of the second week of pregnancy with an initial weight of 210- 250 g. The animals were divided into 2 groups. Immunosuppression was modeled using methotrexate at a dosage of 10 mg/m2 of body area at the beginning of diestrus. The rats were excised at the end of 2 weeks of pregnancy, the absolute and relative mass of the thymus, linear characteristics, and volume were measured. The micromorphometric parameters of the organ and the levels of interleukins in blood plasma were also determined. Results. In the process of studying organometric and micromorphometric indicators, it was noted that the linear dimensions of the organ, its relative and absolute mass, and volume significantly decrease. In addition, all micromorphometric parameters also decrease during the same observation period against the background of significant deviations in the concentration of cytokines in blood plasma relative to the control data. Conclusions. Morphometric changes in the parameters of the organ at different levels of the study indicate systemic changes in the structure of the thymus.
Exploring the Blueprint of Life: The Innovation in Antibody and Protein Design
Authors: Yang Zhiwei , Lushington Gerald H.
Published: February 2025

The innovation in antibody and protein design highlights the transformation from empirical
approaches to sophisticated strategies integrating computational methods and artificial
intelligence (AI). Key principles, such as combinatorial, structure-based, consensus, and computational
designs, have been pivotal in predicting structures from sequences (in silico design). Advances
in tools, like AlphaFold and Rosetta suite, enable accurate structure prediction, facilitating
the development of functional proteins and antibodies. However, challenges remain, including
improving prediction accuracy, modeling flexible regions, understanding structural dynamics, and
designing catalytic and binding sites. Despite these, the field promises groundbreaking advancements
in biomedical sciences, enriching our understanding and serving human health and scientific
discovery.
Estradiol Promotes Endometriosis Progression Via the ERβ/QKI /circSMAD2 Axis
Authors: Peng Yuan , Xiong Wenqian , He Haitang , Liu Hengwei , Fu Tian , Long Xuefeng , Li Xiaoou , Dai Xin , Xu Ying , Zhang Ling , Liu Yi
Published: February 2025

Aims:

The present study aimed to examine the roles of circRNA-circSMAD2 and its
regulatory mechanisms in endometriosis (EMs).

Background:

Evidence has confirmed that circRNAs play multiple roles in regulating the occurrence
and development of EMs, but the regulatory mechanisms of circRNAs in EMs remain
largely unknown.

Objective:

The roles and regulatory mechanisms of circSMAD2 in EMs.

Method:

Eutopic and ectopic endometrium of ovarian EMs as well as normal endometrial
tissues, were used to extract circRNA, mRNA, and total proteins. The human endometrial stromal
cell lines (ThESCs) and endometrial stromal cells (ESCs) were stimulated with different
concentrations or times of 17β-estradiol (E2). The mouse model of EMs was established by implanting
uterine horns onto the peritoneum wall using a suture.

Result:

Compared with normal tissues, the expression of circSMAD2 was significantly decreased
in eutopic and ectopic endometrial tissues. Furthermore, the expression of circSMAD2
was downregulated by E2 in a dose- and time-dependent manner in ThESCs and ESCs. Overexpression
of circSMAD2 inhibited the invasion and migration of ThESCs, while knockdown of
circSMAD2 exerted the opposite effect. The RNA binding protein quaking (QKI), which is involved
in circRNA formation, was lower in eutopic and ectopic endometrial tissues compared to
normal tissues.

conclusion:

The E2/ERβ/QKI/circSMAD2 pathway was involved in cellular migration and invasion in EMs

Conclusion:

Moreover, E2 suppressed the expression of circSMAD2 by inhibiting the expression
of QKI. Additionally, E2 enabled the expression of estrogen receptor beta (ERβ) to inhibit
the expression of QKI and circSMAD2 in vitro and in vivo.

Conclusion:

The E2/ERβ/QKI/circSMAD2 pathway was involved in cellular migration and
invasion in EMs.