bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolic and biochemical profile in women with polycystic ovarian syndrome attending tertiary care centre of central NEPAL
Authors: Rajbanshi Isha , Sharma Vijay Kumar , Tuladhar Eans Tara , Bhattarai Aseem , Raut Mithileshwar , Dubey Raju Kumar , Koirala Poonam , Niraula Apeksha
Published: April 2023

Background

Polycystic Ovarian Syndrome (PCOS) is a common endocrinopathy in women of reproductive age group and is highly associated with an increased risk of diabetes, hypertension, cardiovascular disease, and hyper estrogen-related malignancies in women with PCOS. This study was intended to assess the metabolic and hormonal profile of the patients with polycystic ovarian syndrome attending a tertiary care hospital.

Methodology

A descriptive cross-sectional study was conducted among 107 women diagnosed with polycystic ovarian syndrome from the Department of Clinical Biochemistry of Tribhuvan University and Teaching Hospital. Descriptive analysis was performed to determine the socio-demographic characteristics of the participants. Bivariate analysis was conducted to determine using a t-test for comparing means between two groups and ANOVA for comparing the hormonal and metabolic parameters.

Results

The mean age of the participants was 27 ± 4 years. This study showed that blood pressure was significantly higher in overweight and obese women (p = 0.001). The obese group had significantly higher serum TSH than the normal group (10.04 vs. 2.73, p = 0.001). Abnormal glucose and hyperinsulinemia were present in 4% of the patients, while 40% had Vitamin D deficiency. Hypothyroidism (TSH ≥ 4.5 mIU/ml) was found in 11% of the PCOS participants with a mean value of 6.65 ± 21.17 mIU/ml. Hyperprolactinemia ≥ 26.8 ng/ml was depicted in 21% of the study population with a mean value of 37.25 ± 21.86 ng/ml.

Conclusion

Our study demonstrated that PCOS is most commonly prevalent in young women of the reproductive age group which can lead to reproductive, metabolic, and oncological complications in the long term. LH/ FSH ratio was found to be significantly deranged indicating that PCOS should be diagnosed and treated early in the adolescent age group.
Project DECIDE, part II: decision-making places for people with dementia in Alzheimer’s disease: supporting advance decision-making by improving person-environment fit
Authors: Florack Janina , Abele Christina , Baisch Stefanie , Forstmeier Simon , Garmann Daniel , Grond Martin , Hornke Ingmar , Karakaya Tarik , Karneboge Jonas , Knopf Boris , Lindl Gregor , Müller Tanja , Oswald Frank , Pfeiffer Nathalie , Prvulovic David , Poth Aoife , Reif Andreas , Schmidtmann Irene , Theile-Schürholz Anna , Ullrich Heiko , Haberstroh Julia
Published: April 2023

Background

The UN Convention on the Rights of Persons with Disabilities, and the reformed guardianship law in Germany, require that persons with a disability, including people with dementia in Alzheimer’s disease (PwAD), are supported in making self-determined decisions. This support is achieved through communication. While content-related communication is a deficit of PwAD, relational aspects of communication are a resource. Research in supported decision-making (SDM) has investigated the effectiveness of different content-related support strategies for PwAD but has only succeeded in improving understanding, which, although one criterion of capacity to consent, is not sufficient to ensure overall capacity to consent. The aim of the ‘spatial intervention study’ of the DECIDE project is to examine an innovative resource-oriented SDM approach that focuses on relational aspects. We hypothesise that talking to PwAD in their familiar home setting (as opposed to a clinical setting) will reduce the complexity of the decision-making process and enhance overall capacity to consent.

Methods

People with a suspected or confirmed diagnosis of dementia in Alzheimer’s disease will be recruited from two memory clinics (N = 80). We will use a randomised crossover design to investigate the intervention effect of the decision-making place on capacity to consent. Besides reasoning capacity, which is part of overall capacity to consent and will be the primary outcome, various secondary outcomes (e.g., other aspects of capacity to consent, subjective task complexity, decisional conflict) and suspected moderating or mediating variables (e.g., meaning of home, demographic characteristics) will be assessed.

Discussion

The results of the study will be used to develop a new SDM strategy that is based on relational resources for PwAD. If a change in location achieves the anticipated improvement in capacity to consent, future research should focus on implementing this SDM strategy in a cost-effective manner in clinical practice.

Trial registration:DRKS00030799.
Patella component diameters of 38 mm and up might be associated with higher revision rates after patella resurfacing
Authors: Jungwirth-Weinberger Anna , List Kilian , Bechler Ulrich , Hanreich Carola , Rueckl Stefan , Boettner Friedrich
Published: April 2023

Purpose

Patellar resurfacing is considered the standard of care for total knee arthroplasty in the USA. Complications of patella resurfacing include aseptic loosening or patella fractures and can threaten the integrity of the extensor mechanism. The goal of this study was to report on patella button revision rates in posterior stabilized total knee arthroplasty.

Material and methods

Between 01/2010 and 08/2016 patella buttons were implanted in 1056 patients (267 men and 550 women) as part of a posterior stabilized total knee arthroplasty.

Results

Of 1056 cases, 35 cases (14 women, 15 men, 5 bilateral, 3.3%) showed early loosening at a mean 52.5 months postoperatively. Patella components of 38 mm or larger diameters showed a significantly higher loosening rate than the 29, 32, 35 mm buttons (p < 0.01). Mean BMI of patients identified with aseptic loosening was 31.7 kg/m2, mean age at time of revision surgery was 63.3 years. All of the patients with loosening of the patella button required revision surgery; in 33 cases an exchange of the button was performed, in two cases a removal of the button and patellar bone grafting was indicated. No complications occurred after revision surgery.

Conclusion

The current study reports a 3.3% patella loosening rate during this mid-term follow-up. Size 38 mm and larger patella components showed a significantly higher revision rate than smaller buttons and the authors advise caution when using large diameter patella components.
Cardiorespiratory arrest during and after nuss procedure: case report
Authors: Cujiño-Álvarez Indira F. , Torres-Salazar Daniela , Velásquez-Galvis Mauricio
Published: April 2023

Background

Pectum excavatum is a congenital thoracic alteration that can present important physiological alterations depending on the severity of the case. The Nuss procedure is a minimally invasive technique for managing chest wall deformity, in which there is a risk of perioperative complications.

Case presentation

This article presents the case of a 16-year-old patient who underwent placement of a Nuss bar and suffered intraoperative and postoperative cardiorespiratory arrest.

Conclusions

it is important to consider the possible early and late complications scenarios as well as their treatment in patients with pectum excavatum scheduled for a Nuss procedure.
Clinical audit in European radiology: current status and recommendations for improvement endorsed by the European Society of Radiology (ESR)
Authors: Howlett David C. , Kumi Paulette , Kloeckner Roman , Bargallo Nuria , Baessler Bettina , Becker Minerva , Ebdon-Jackson Steve , Karoussou-Schreiner Alexandra , Loewe Christian , Sans Merce Marta , Serrallonga-Mercader Marta , Syrgiamiotis Vasilis ,   European Society of Radiology
Published: April 2023

Clinical audit is an important quality improvement activity and has significant benefits for patients in terms of enhanced care, safety, experience and outcomes. Clinical audit in support of radiation protection is mandated within the European Council Basic Safety Standards Directive (BSSD), 2013/59/Euratom. The European Society of Radiology (ESR) has recognised clinical audit as an area of particular importance in the delivery of safe and effective health care. The ESR, alongside other European organisations and professional bodies, has developed a range of clinical audit-related initiatives to support European radiology departments in developing a clinical audit infrastructure and fulfilling their legal obligations. However, work by the European Commission, the ESR and other agencies has demonstrated a persisting variability in clinical audit uptake and implementation across Europe and a lack of awareness of the BSSD clinical audit requirements. In recognition of these findings, the European Commission supported the QuADRANT project, led by the ESR and in partnership with ESTRO (European Association of Radiotherapy and Oncology) and EANM (European Association of Nuclear Medicine). QuADRANT was a 30-month project which completed in Summer 2022, aiming to provide an overview of the status of European clinical audit and identifying barriers and challenges to clinical audit uptake and implementation. This paper summarises the current position of European radiological clinical audit and considers the barriers and challenges that exist. Reference is made to the QuADRANT project, and a range of potential solutions are suggested to enhance radiological clinical audit across Europe.
Overlap syndrome of primary biliary cholangitis and primary sclerosing cholangitis: two case reports
Authors: Yacoub Haythem , Ben Azouz Sarra , Hassine Hajer , Debbabi Habiba , Cherif Dhouha , Ghayeb Feriel , Boukriba Seif , Kchir Héla , Maamouri Nadia
Published: April 2023

Background

Overlap syndrome between primary biliary cholangitis and primary sclerosing cholangitis is an extremely rare condition that has been reported in only few published cases so far in the literature. We highlight here the rarity of this condition and indicate the importance of its recognition.

Case presentation

We report two cases showing the manifestations of both primary biliary cholangitis and primary sclerosing cholangitis in two Tunisian female patients aged 74 and 42 years, respectively. The first case is a woman who was initially diagnosed with decompensated cirrhosis. Magnetic resonance cholangiopancreatography showed multiple strictures of the common bile duct, and histological findings led to the diagnosis of primary biliary cholangitis/primary sclerosing cholangitis. She was successfully treated with ursodeoxycholic acid. The second case is a middle-aged woman, suffering from primary biliary cholangitis and who was treated with ursodeoxycholic acid. At her 12 month follow-up appointment, she presented with a partial clinical and biochemical response. Tests showed normal thyroid function, liver autoimmune tests for autoimmune hepatitis were negative, and celiac disease markers were also negative. The diagnosis of overlap syndrome of primary biliary cholangitis/primary sclerosing cholangitis was finally made on the results of magnetic resonance cholangiopancreatography that showed multiple strictures of the common as well as intrahepatic bile ducts. The patient was put on ursodeoxycholic acid at a higher dose.

Conclusions

Our cases raise awareness for this rare condition and indicate the importance of recognizing a possible overlap syndrome, especially in patients with primary biliary cholangitis, to optimize treatment. We suggest considering the overlap syndrome of primary biliary cholangitis/primary sclerosing cholangitis when a patient presents with the diagnostic criteria of both diseases.
Large-scale evaluation of k-fold cross-validation ensembles for uncertainty estimation
Authors: Dutschmann Thomas-Martin , Kinzel Lennart , ter Laak Antonius , Baumann Knut
Published: April 2023

It is insightful to report an estimator that describes how certain a model is in a prediction, additionally to the prediction alone. For regression tasks, most approaches implement a variation of the ensemble method, apart from few exceptions. Instead of a single estimator, a group of estimators yields several predictions for an input. The uncertainty can then be quantified by measuring the disagreement between the predictions, for example by the standard deviation. In theory, ensembles should not only provide uncertainties, they also boost the predictive performance by reducing errors arising from variance. Despite the development of novel methods, they are still considered the “golden-standard” to quantify the uncertainty of regression models. Subsampling-based methods to obtain ensembles can be applied to all models, regardless whether they are related to deep learning or traditional machine learning. However, little attention has been given to the question whether the ensemble method is applicable to virtually all scenarios occurring in the field of cheminformatics. In a widespread and diversified attempt, ensembles are evaluated for 32 datasets of different sizes and modeling difficulty, ranging from physicochemical properties to biological activities. For increasing ensemble sizes with up to 200 members, the predictive performance as well as the applicability as uncertainty estimator are shown for all combinations of five modeling techniques and four molecular featurizations. Useful recommendations were derived for practitioners regarding the success and minimum size of ensembles, depending on whether predictive performance or uncertainty quantification is of more importance for the task at hand.
Predicting microbial community compositions in wastewater treatment plants using artificial neural networks
Authors: Liu Xiaonan , Nie Yong , Wu Xiao-Lei
Published: April 2023

Background

Activated sludge (AS) of wastewater treatment plants (WWTPs) is one of the world’s largest artificial microbial ecosystems and the microbial community of the AS system is closely related to WWTPs' performance. However, how to predict its community structure is still unclear.

Results

Here, we used artificial neural networks (ANN) to predict the microbial compositions of AS systems collected from WWTPs located worldwide. The predictive accuracy R21:1 of the Shannon–Wiener index reached 60.42%, and the average R21:1 of amplicon sequence variants (ASVs) appearing in at least 10% of samples and core taxa were 35.09% and 42.99%, respectively. We also found that the predictability of ASVs was significantly positively correlated with their relative abundance and occurrence frequency, but significantly negatively correlated with potential migration rate. The typical functional groups such as nitrifiers, denitrifiers, polyphosphate-accumulating organisms (PAOs), glycogen-accumulating organisms (GAOs), and filamentous organisms in AS systems could also be well recovered using ANN models, with R21:1 ranging from 32.62% to 56.81%. Furthermore, we found that whether industry wastewater source contained in inflow (IndConInf) had good predictive abilities, although its correlation with ASVs in the Mantel test analysis was weak, which suggested important factors that cannot be identified using traditional methods may be highlighted by the ANN model.

Conclusions

We demonstrated that the microbial compositions and major functional groups of AS systems are predictable using our approach, and IndConInf has a significant impact on the prediction. Our results provide a better understanding of the factors affecting AS communities through the prediction of the microbial community of AS systems, which could lead to insights for improved operating parameters and control of community structure.
Orthorexic eating behaviors are not all pathological: a French validation of the Teruel Orthorexia Scale (TOS)
Authors: Lasson Clotilde , Rousseau Amélie , Vicente Siobhan , Goutaudier Nelly , Romo Lucia , Roncero María , Barrada Juan Ramón
Published: April 2023

As no French validated measurement tool distinguishing healthy orthorexia (HeOr) from orthorexia nervosa (OrNe) currently exists, this study aimed at examining psychometric properties of the French version of the Teruel Orthorexia Scale (TOS). A sample of 799 participants (Mean [SD] age: 28.5 [12.1] years-old) completed the French versions of the TOS, the Düsseldorfer Orthorexia Skala, the Eating Disorder Examination-Questionnaire, and the Obsessive–Compulsive Inventory-Revised. Confirmatory factor analysis and exploratory structural equation modeling (ESEM) were used. Although the bidimensional model, with OrNe and HeOr, of the original 17-item version showed an adequate fit, we suggest excluding items 9 and 15. The bidimensional model for the shortened version provided a satisfactory fit (ESEM model: CFI = .963, TLI = .949, RMSEA = .068). The mean loading was .65 for HeOr and .70 for OrNe. The internal consistency of both dimensions was adequate (αHeOr = .83 and αOrNe = .81). Partial correlations showed that eating disorders and obsessive–compulsive symptomatology measures were positively related to OrNe and unrelated or negatively related to HeOr. The scores from the 15-item French version of the TOS in the current sample appears to present an adequate internal consistency, pattern of associations in line with what was theoretically expected, and promising for differentiating both types of orthorexia in a French population. We discuss why both dimensions of orthorexia should be considered in this area of research.
Sinonasal malignancies: Histopathological entities, regional involvement and long-term outcome
Authors: Anschuetz Lukas , Hohenberger Ralph , Kaecker Christoph , Elicin Olgun , Giger Roland , Caversaccio Marco
Published: April 2023

Background

To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome.

Methods

Patients (n = 144) with malignant tumors of the nasal cavity and paranasal sinuses were treated at our tertiary referral center between 2008 and 2019. A chart review on patient and tumor characteristics, treatment and long-term outcome was performed.

Results

Most frequent histological types were squamous cell carcinoma (SCC) (n = 74), adenocarcinoma (n = 24) and mucosal melanoma (n = 18). Primary therapy was surgery in 66% of patients (n = 95) of which 65.8% (n = 66) received adjuvant radiotherapy. Twenty patients (13.8%) were initially staged as cN + and in seven cases, pN + status was histopathologically confirmed. Fifty-six of 130 patients (43.1%) had a relapse after curative intended therapy, including nine loco-regional (6.9%) and seven isolated regional recurrences (5.4%). Twelve of these 16 patients with (loco-)regional recurrence had SCC. Adenoid cystic carcinoma (87.5%) and SCC (65.3%) showed the best long-term overall survival.

Conclusions

Regional involvement and regional recurrence are scarce. Because of rarity and heterogeneity, evidence on therapeutic management is sparse resulting in the lack of clinical guidelines.

Graphical Abstract
Extra Consciousness, Extra Fingers: Automatic Writing and Disabled Authorship
Authors: Mullaney Clare
Published: April 2023

Nineteenth-century Spiritualism championed women with chronic illnesses as the ideal conduits for mediumship due to their assumed sensitivity. Positioning the movement’s many historical iterations of automatic writing as central to disability history, this article turns to Gertrude Stein and Lucille Clifton, who center extrasensory perceptions in the compositional scene. Foregrounding mind and body, they upend the privileging of the rational male subject who dominates accounts of authorship in literary studies. By modeling collaborative forms of writing that exceed consciousness, Stein and Clifton make way for embracing disabled authorship in our past and present.
Introduction
Authors: Gladstone Jason , Goodman Nan , Mattar Karim
Published: April 2023

This introduction charts the editors’ evolving understanding of the implications of the COVID-19 pandemic for literary studies in the real time of the crisis. Oriented around the themes of friendship and community, the introduction articulates the overall ambition of the issue as one of maintaining an engaged intellectual community during the isolation imposed by the pandemic. Foregrounding narrative as the issue’s major emphasis, it describes how the issue engages with pandemic storytelling in relation to literary history and literary production, environmental literary studies, and higher education and the profession. Finally, it provides an overview of the issue’s sections and essays.
Externalities in International Tax Enforcement: Theory and Evidence
Authors: Tørsløv Thomas , Wier Ludvig , Zucman Gabriel
Published: April 2023

We show that the fiscal authorities of high-tax countries can lack the incentives to combat profit shifting to tax havens. Instead, they have incentives to focus their enforcement efforts on relocating profits booked by multinationals in other high-tax countries, crowding out the enforcement on transactions that shift profits to tax havens, and reducing the global tax payments of multinational companies. The predictions of our model are motivated and supported by the analysis of two new datasets: the universe of transfer price corrections conducted by the Danish tax authority, and new cross-country data on international tax enforcement. (JEL E62, F23, H25, H26, H87, K34)
Pensions and Fertility: Microeconomic Evidence
Authors: Danzer Alexander M. , Zyska Lennard
Published: April 2023

This study identifies the causal effect of pension generosity on women’s fertility behavior. It capitalizes on Brazil’s expansion of the pension system to rural workers, whose pension wealth subsequently more than tripled. Difference-in-difference, instrumental variable, and event study methods show that the pension reform reduces the propensity of childbearing of women of fertile age by 8 percent in the short run. Completed fertility declines by 1.3 children within 20 years after the reform, reducing the contribution base of the pay-as-you-go long run. The fertility response is strongest at higher birth parities, among older women, and among mothers with sons. (JEL H55, I38, J13, J16, O15)
No Spending without Representation: School Boards and the Racial Gap in Education Finance
Authors: Fischer Brett
Published: April 2023

This paper provides causal evidence that greater minority representation on school boards translates into greater investment in minority students. Focusing on California school boards, I instrument for minority (specifically, Hispanic) representation using random ballot ordering and leverage new data from a statewide capital investment program to capture intradistrict resource allocations. I show that Hispanic board members invest the marginal dollar in high-Hispanic schools within their districts. High-Hispanic schools also exhibit gains in student achievement and decreased teacher turnover. I conclude that enhancing minority representation on school boards could help combat long-standing disparities in education. JEL (H75, I21, I22, I24, J15)
Profiting from Most-Favored-Customer Procurement Rules: Evidence from Medicaid
Authors: Feng Josh , Hwang Thomas , Maini Luca
Published: April 2023

Using a difference-in-difference approach, we find that an increase to Medicaid’s minimum drug rebate under the Affordable Care Act in 2010 lowered non-Medicaid drug spending by 2.5 percent. A stylized bargaining model shows that this is likely driven by the interaction of this reform with Medicaid’s “most-favored customer” clause (MFCC). By examining the response of drugs that faced a change in incentives equivalent to the removal of Medicaid’s MFCC, we estimate that removing the Medicaid MFCC would have reduced overall 2010 non-Medicaid drug spending by an additional 3.5 percent, though it would have likely also increased Medicaid spending. (JEL C78, H51, I18, I38, L65)
International Chinese Language Education in the Context of Third Language Acquisition: the Value, Connotation and Practical Approaches
Authors: Tang Ying
Published: April 2023

International Chinese language education has long been incorporated into the theoretical framework of Second Language Acquisition (SLA), while Chinese is being learned as a third language in most overseas countries. Introducing the theory of third language acquisition helps reveal the pattern of Chinese language acquisition for multilingual learners and promotes the further development of international Chinese language education.This paper reviews the history, content and current status of third language acquisition research and finds that there are three aspects of coupling between the pedagogical elements embedded in international Chinese education and the paradigm of third language acquisition: first, the cognitive advantage of multilingual learners promotes the transformation of instructional goals from perceptual to rational cognition; second, interlanguage transfer and affective strategy convergence prompt teaching approaches to expand from the theory of third language; third, constructing the model of third language acquisition can improve the explanatory power of second language teaching theory in international Chinese language education. This research points out that the introduction of third language acquisition can help build the teaching model that conforms to the cognitive laws of multilingual learners, and that it is necessary to develop specialized teaching materials that follow the rules of third language acquisition based on the model of “practice, evaluation, development”, to integrated teaching with language meaning, language form, and language use as content, and to developing multilingualist's multilingualism with a focus on commonality, distance and awareness of language.
Supplemental figures for "Station Aridity in Weather Monitoring Networks: Evidence from the Oklahoma Mesonet"
Authors: Singh Aseem , Taghvaeian Saleh , Mirchi Ali , moriasi daniel
Published: April 2023

  

This Supplementary Material file includes three figures related to the journal article entitled "Station Aridity in Weather Monitoring Networks: Evidence from the Oklahoma Mesonet."
Exploring the potency of Streptomyces koyangensis strain SHP 9-3 isolated from the soil of Enggano Island (Indonesia) as an antibacterial source
Authors: PAHIRA DELVI SARA JIHAN , DAMAYANTI EMA , LISDIYANTI PUSPITA , MUSTOFA MUSTOFA , HERTIANI TRIANA
Published: April 2023

Abstract. Pahira DSJ, Damayanti E, Lisdiyanti P, Mustofa, Hertiani T. 2023. Exploring the potency of Streptomyces koyangensis strain SHP 9-3 isolated from the soil of Enggano Island (Indonesia) as an antibacterial source. Biodiversitas 24: 1460-1466. Streptomyces is a Gram-positive bacterium with the potential a produce beneficial antimicrobials. This study aimed to determine the antimicrobial activity, morphological characteristics, cytotoxicity, and chemical profile of S. koyangensis SHP 9-3. This bacterium was isolated from Enggano Island, Indonesia, and the morphological characteristics were determined using a Scanning Electron Microscope (SEM). Cultivation was conducted in the International Streptomyces Project (ISP-2) media using baffled flasks and a shaker incubator. The secondary metabolites were conducted on the extract against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans by a twofold dilution method. Concurrently, cytotoxicity testing was done on Vero cells. The extract’s chemical profile was analyzed using LC-MS/MS. The results showed a prominent antibacterial activity as the extract inhibited the growth of S. aureus and C. albicans at 7.81 µg/mL. However, a growth inhibition against E. coli was observed at 250 µg/mL and P. aeruginosa at 31.25 µg/mL. The cytotoxic test showed the IC50 value on Vero cells was 5,015 µg/mL, indicating that the extract was nontoxic against Vero cells. The chemical profile of the extract by LC-MS/MS revealed the presence of five major components, i.e., cyclo (Pro-Val) (C10H16N2O2), kuraramine (C12H18N2O2), 1,4-diphenyl-1-pentanone (C17H18O), (3S,4S)-4-amino-3-hydroxy-6-methyl heptanoic acid (C21H42N2O7), and 2-ethyl-8-methyl-2,8-diazaspiro (4,5) decane-1,3-dione (C11H18N2O2).
Diversity of medicinal plants sold in the traditional markets in Jambi, Indonesia
Authors: ASRA REVIS , IHSAN MAHYA , ANDRIANI FITRIA , SILALAHI MARINA , FIJRIDIYANTO IZU ANDRY , MARYANI ANIS TATIK
Published: April 2023

Abstract. Asra R, Ihsan M, Andriani F, Silalahi M, Fijridiyanto IA, Maryani AT. 2023. Diversity of medicinal plants sold in the traditional markets in Jambi, Indonesia. Biodiversitas 24: 1544-1550. Traditional markets are places for local people to do transactions of medicinal plants and traditional cooking spices. The use of plants as traditional medicine is high in Jambi Province, Indonesia. This is because the population in Jambi Province consists of several ethnicities that still practice traditional medicine. This work aims to document and inventory local knowledge of medicinal plants in Jambi's two most important markets. An interview, participatory observation, and documentation were used for data collection. There were 14 respondents of various ages chosen randomly. Data analysis used the Shannon-Wiener diversity index (H') and Jaccard similarity index (Ji). A total of 78 medicinal plant species belonging to 42 families were found. Most species were from Zingiberaceae (14 species) and Rutaceae (9 species). The diversity indexes (H') of medicinal plants at traditional markets in Jambi are high in the Angso Duo (H'= 4.295) and Talang Banjar Markets (H'= 4.277). The similarity index (Ji) in both markets was high (Ji= 88,5%). Based on the type of disease, the medicinal plants used are classified into 19 groups. The plants are mainly used for digestive disorders (29.49%), muscle tenderness (20.51%), respiratory disorders (14.10%), skin (12.82 %), and cancer (12.82 %). The part of the plant most used for medicine is fruit (26.92%), followed by rhizomes (19.23%) and flowers (15.38%). The results can be used for bioprospecting studies that will lead to the discovery of new drugs.
Characterization of silver nanoparticles (AgNPs) synthesized from Piper ornatum leaf extract and its activity against food borne pathogen Staphylococcus aureus
Authors: DEWI FIRLI RAHMAH PRIMULA , LIM VUANGHAO , ROSYIDAH A’LIYATUR , FATIMAH FATIMAH , WAHYUNINGSIH SRI PUJI ASTUTI , ZUBAIDAH UMMI
Published: April 2023

Abstract. Dewi FRP, Lim V, Rosyidah A, Fatimah, Wahyuningsih SPA, Zubaidah U. 2023. Characterization of silver nanoparticles (AgNPs) synthesized from Piper ornatumleaf extract and its activity against food borne pathogen Staphylococcus aureus. Biodiversitas 24: 1742-1748. Staphylococcus aureusis the most recurrent food borne pathogen
that commonly resists antibiotics. Silver nanoparticles (AgNPs) have potential to solve bacterial multidrug resistance.
This study aims to assess bactericidal activityof AgNPs against S. aureussynthesized from Piper ornatumleaf extract. Biosynthesis was performed by mixing P. ornatumextract with AgNO3aqueous solution and then incubating for 24 h at room temperature under dark condition. The formation of AgNPs was confirmed by changing optical color from light yellowish to dark brown with a peak of UV spectrum at ~500 nm. According to SEM imaging, AgNPs had spherical form whereas EDS analysis revealed strong signal at 3 kV indicating existence of silver element. Meanwhile, face-centered cubic structures of AgNPs were indicated by XRD analysis. FTIR analysis confirmed ketone, flouro, and amine as functional groups presented in extract were essential for the bioreduction of silver nitrate to silver nanoparticles. This study revealed that AgNPs have a potent bactericidal effect. In vitroevaluation using agar well-diffusion assay showed high inhibition zone of S. aureus (14.28±0.26) upon treating with 25 µg/m L AgNPs while MIC value was 5 µg/mL. However, antibiotic erythromycin and chloramphenicol respectively exhibited better inhibition zone and MIC value.
Challenges in Talus Fracture-dislocations – A Case Report
Authors: Kawtharani Firas , Geagea Eddie
Published: April 2023

Introduction: Fractures of the talus and its associated hindfoot dislocations are uncommon. They usually result from high-energy trauma. These fractures can lead to permanent disability. Optimal treatment relies on accurate evaluation of the injury with proper imaging to identify the fracture pattern and associated injuries and to be able to make an appropriate pre-operative plan. Avoiding soft-tissue complications, avascular necrosis, and post-traumatic arthrosis are the main goal of treatment. Case Report: We report a case of concomitant left talar neck and body fracture associated with a fracture of the medial malleolus in a 46-year-old male. We performed a closed reduction of the subtalar joint followed by an open reduction internal fixation of the talar neck/body and medial malleolus fractures. Conclusion: At 12 weeks following the treatment, the patient had good movement with minimal discomfort on dorsiflexion, he was able to ambulate with no limp. Radiographs showed appropriate healing of the fracture. The patient was able to go back to his work with no restrictions as of publication of this report. Talus fracture dislocations are not benign in nature. Meticulous attention to soft-tissue management, anatomic reduction and fixation as well as adequate post-operative follow-up is needed to obtain a satisfactory outcome and avoid the detrimental sequalae of avascular necrosis and post-traumatic arthrosis. Keywords: Talus fracture dislocation, anatomic reduction, avascular necrosis, post-traumatic arthritis, outcome, return to work.
Broken Intraluminal Needle in an Intravenous Drug User – A Case Report and Review
Authors: Seth Akshay , Bansal Nitish , Tiwari Punit , Jain Saurav
Published: April 2023

Introduction: Intravenous injections are an everyday practice in the health-care sector and are also frequently abused by drug abusers. One rare complication of intravenous injections is venous intraluminal breakage of the needle, which is a matter of concern due to the possible embolization of needle fragments in the body. Case Report: We report our case of an intravenous drug abuser with an intraluminal breakage of a needle presenting within 2 h of the incidence. The broken needle fragment was retrieved successfully at the local injection site. Conclusion: Intraluminal intravenous needle breakage should be treated as an emergency, and a tourniquet should be applied as soon as possible. Keywords: Intravenous, drug abusers, intraluminal needle breakage, needle retrieval.
Design of a compact triple-channel panoramic stereo imaging system
Authors: Pan Ning , Gao Shaohua , Bai Jian , Wang Kaiwei
Published: April 2023

We propose a compact form of the triple-channel panoramic annular lens (PAL) with a stereo field and no central blind area based on polarization technology, which solves the problem that the traditional stereo panoramic system always has a large and complex mirror in front to reflect light. Based on the traditional dual-channel structure, we apply polarization technology to the first reflective surface to create a third channel for the stereovision. The field of view (FoV) of the front channel is 360° × (0° − 40°), the FoV of the side channel is 360° × (40° − 105°) and the stereo FoV is 360° × (20° − 50°). The Airy radii of the front channel, the side channel, and the stereo channel are 3.374 µm, 3.372 µm, and 3.360 µm, respectively. The modulation transfer function at 147 lp/mm is greater than 0.13 in the front and stereo channels and greater than 0.42 in the side channel. The F − θ distortion of all FoVs is less than 10%. This system shows a promising way to achieve stereovision without adding complex structures on the original basis.
Protecting the public interest while regulating health professionals providing virtual care: A scoping review
Authors: Leslie Kathleen , Myles Sophia , Schiller Catharine J. , Alraja Abeer A. , Nelson Sioban , Adams Tracey L.
Published: April 2023

Technology is transforming service delivery in many health professions, particularly with the rapid shift to virtual care during the COVID-19 pandemic. Health profession regulators must navigate legal and ethical complexities to facilitate virtual care while upholding their mandate to protect the public interest. The objectives of this scoping review were to examine how the public interest is protected when regulating health professionals who provide virtual care, discuss policy and practice implications of virtual care, and make recommendations for future research. We searched six multidisciplinary databases for academic literature published in English between January 2015 and May 2021. We also searched specific databases and websites for relevant grey literature. After screening, 59 academic articles and 18 grey literature sources were included for analysis. We identified five key findings: the public interest when regulating health professionals providing virtual care was only implicitly considered in most of the literature; when the public interest was discussed, the dimension of access was emphasized; criticism in the literature focused on social ideologies driving regulation that may inhibit more widespread use of virtual care; subnational licensure was viewed as a barrier; and the demand for virtual care during COVID-19 catalyzed licensure and scope of practice changes. Overall, virtual care introduces new areas of risk, potential harm, and inequity that health profession regulators need to address as technology continues to evolve. Regulators have an essential role in providing clear standards and guidelines around virtual care, including what is required for competent practice. There are indications that the public interest concept is evolving in relation to virtual care as regulators continue to balance public safety, equitable access to services, and economic competitiveness.
A modelling assessment of short- and medium-term risks of programme interruptions for gambiense human African trypanosomiasis in the DRC
Authors: Huang Ching-I , Crump Ronald E. , Crowley Emily H. , Hope Andrew , Bessell Paul R. , Shampa Chansy , Mwamba Miaka Erick , Rock Kat S.
Published: April 2023

Gambiense human African trypanosomiasis (gHAT) is a deadly vector-borne, neglected tropical disease found in West and Central Africa targeted for elimination of transmission (EoT) by 2030. The recent pandemic has illustrated how it can be important to quantify the impact that unplanned disruption to programme activities may have in achieving EoT. We used a previously developed model of gHAT fitted to data from the Democratic Republic of the Congo, the country with the highest global case burden, to explore how interruptions to intervention activities, due to e.g. COVID-19, Ebola or political instability, could impact progress towards EoT and gHAT burden. We simulated transmission and reporting dynamics in 38 regions within Kwilu, Mai Ndombe and Kwango provinces under six interruption scenarios lasting for nine or twenty-one months. Included in the interruption scenarios are the cessation of active screening in all scenarios and a reduction in passive detection rates and a delay or suspension of vector control deployments in some scenarios. Our results indicate that, even under the most extreme 21-month interruption scenario, EoT is not predicted to be delayed by more than one additional year compared to the length of the interruption. If existing vector control deployments continue, we predict no delay in achieving EoT even when both active and passive screening activities are interrupted. If passive screening remains as functional as in 2019, we expect a marginal negative impact on transmission, however this depends on the strength of passive screening in each health zone. We predict a pronounced increase in additional gHAT disease burden (morbidity and mortality) in many health zones if both active and passive screening were interrupted compared to the interruption of active screening alone. The ability to continue existing vector control during medical activity interruption is also predicted to avert a moderate proportion of disease burden.
Impacts of social isolation and risk perception on social networking intensity among university students during covid-19
Authors: Jo Hyeon , Baek Eun-Mi
Published: April 2023

This paper aims to examine the impacts of social isolation and risk perception on social networking intensity during COVID-19. Data was gathered from 345 university students. The present study empirically analyzed the data through a partial least squares methodology. The analysis showed that perceived behavioral control positively impacts social networking intensity. Affective risk perception positively affects subjective norms and perceived behavioral control. Cognitive risk perception has a significant association with both subjective norms and perceived behavioral control. Moreover, cabin fever syndrome serves as the key determinant of both sub-scales of risk perception. This study is novel in that it organically examines the effects of risk perception, social action, and closure on social networking. The current research and findings will offer useful implications for service providers in the social network industry.
A distributed computing model for big data anonymization in the networks
Authors: Ashkouti Farough , Khamforoosh Keyhan
Published: April 2023

Recently big data and its applications had sharp growth in various fields such as IoT, bioinformatics, eCommerce, and social media. The huge volume of data incurred enormous challenges to the architecture, infrastructure, and computing capacity of IT systems. Therefore, the compelling need of the scientific and industrial community is large-scale and robust computing systems. Since one of the characteristics of big data is value, data should be published for analysts to extract useful patterns from them. However, data publishing may lead to the disclosure of individuals’ private information. Among the modern parallel computing platforms, Apache Spark is a fast and in-memory computing framework for large-scale data processing that provides high scalability by introducing the resilient distributed dataset (RDDs). In terms of performance, Due to in-memory computations, it is 100 times faster than Hadoop. Therefore, Apache Spark is one of the essential frameworks to implement distributed methods for privacy-preserving in big data publishing (PPBDP). This paper uses the RDD programming of Apache Spark to propose an efficient parallel implementation of a new computing model for big data anonymization. This computing model has three-phase of in-memory computations to address the runtime, scalability, and performance of large-scale data anonymization. The model supports partition-based data clustering algorithms to preserve the λ-diversity privacy model by using transformation and actions on RDDs. Therefore, the authors have investigated Spark-based implementation for preserving the λ-diversity privacy model by two designed City block and Pearson distance functions. The results of the paper provide a comprehensive guideline allowing the researchers to apply Apache Spark in their own researches.
„FÜLEMÜLE FANTÁZIA” A zeneművészeti ág átmenetet és tehetséggondozást segítő tevékenysége gyakorlóiskolánkban
Authors: Bubla Bence , Diamant Ágnes , Hegyközi Tamás
Published: April 2023

Az óvodából az iskolába való átmenet megkönnyítésére „Fülemüle fantázia” címmel interaktív műhelygyakorlatot tartottak a zeneművészeti ág tanárai óvópedagógus kollégák részére. Az előadás célja, hogy a résztvevőknek bemutassák a gyakorlóiskolában folyó zeneművészeti munkát, valamint közös tevékenység kapcsán létrejöjjön egy szakmai párbeszéd óvópedagógusok, ének-zenét és szolfézst, valamint hangszert tanító tanítók és tanárok között.
Szelíd nyelvi nevelés
Authors: Sárvári Tünde
Published: April 2023

Napjaink kulcskompetenciái közé tartoznak a kommunikációs kompetenciák. A 2020-ban kiadott Nemzeti alaptanterv, amely a hazai oktatás-nevelés alapdokumentuma, az eddigi gyakorlattól eltérően ezen a kompetenciaterületen belül egységben szemléli az anyanyelvi és az idegen nyelvi kommunikációs kompetenciákat. Ezzel is hangsúlyozni kívánja, hogy hazánk elkötelezett az egyéni többnyelvűség elve mellett. Az egyéni többnyelvűség fejlesztésének egyik lehetősége a kisgyermekkori idegennyelv-elsajátítás. Jelen tanulmány ennek a speciális tanulási és tanítási folyamatnak a sajátosságaira fókuszál. Rövid elméleti áttekintést követően konkrét gyakorlati példákkal szemléltetve mutatja be a gyermeki tanulás idegennyelv-oktatásban is eredményesen alkalmazható útját, a szelíd nyelvi nevelést, amely az óvodából az iskolába történő átmenetet is megkönnyíti.
Determination of Pesticides in Dead Honeybees
Authors: Kozhushkevich A.I. , Kozeicheva E.S. , Ovcharenko V.V. , Lebedev A.M. , Kish L.K.
Published: April 2023

Pesticide residues were analyzed in dead honeybees by gas chromatography-tandem mass spectrometry
(GC-MS/MS). Sample preparation using QuEChERS was followed by purification on a mixture of
PSA and C18 sorbents. The extraction efficiency of > 80% was obtained for all analytes and pesticides
were quantified in the range of 5-1000 ng/g. This method was used for investigating incidents of
honeybees poisoning by pesticides. Fipronil was detected in all of the investigated samples originating
from different regions of Russia. Additionally, τ-fluvalinate was detected in three samples.
Biogenic Synthesis of Iron Oxide Nanoparticles using
Bergenia ligulata Rhizome Extract and their Biological Activities
Authors: Dulta Kanika , Theresa Umeh Chisom , Paul Madhumita , Das Sushmita Nama , Kamran Mohd , Chauhan P.K.
Published: April 2023

Over the last few decades, nanoparticles were synthesized using various methods. Currently, studies
are more focussed towards the biogenic synthesis of nanoparticles which has proven to simple,
environmental-friendly, convenient and non-toxic as compared to other conventional methods. This
work describes the biosynthesis of iron oxide nanoparticles (FeO NPs) using Bergenia ligulata rhizome
extract. The synthesis of FeO NPs was validated by visual inspections when the colour of solution
changed from dark brown to blackish brown. Other characterization including UV-visible spectroscopy,
FTIR, XRD, DLS and stability tests were also performed. UV-visible spectrum of FeO NPs revealed
high signal at 290 nm. The FTIR spectroscopy analysis revealed various functional groups at different
bands. XRD results confirms the crystalline structure of FeO NPs. The size and stability of the
synthesized nanoparticles was studied by DLS analysis and stability test. Plant extracts and NPs
produced were used for a quantitative study that revealed phenolic and flavonoid compounds in high
concentration. ABTS and DPPH tests were carried out to assess the in vitro radical scavenging activities.
Further, the antifungal activity was performed against Rosellinia necatrix, Fusarium spp, Sclerotinia sclerotiorum. This study confirms that the synthesized FeO NPs are a novel natural preservative with possible uses in agricultural applications.
Determination of Glyphosate, Aminomethylphosphonic
Acid and Glufosinate in Tea Samples of Russia
Authors: Sorokin A.V. , Kish L.K.
Published: April 2023

A method for the determination of glyphosate (Gly), glufosinate (Glu) and aminomethylphosphonic
acid (AMPA) was developed and validated in tea samples (loose leaf and tea-bag tea types) using
reversed-phase high performance liquid chromatography (RP-HPLC) coupled with tandem
mass-spectrometry. The sample preparation method was consists of: extraction by acidified water
followed by SPE on Oasis HLB, derivatization by FMOC-Cl, concentration and usage of another SPE
stage on Oasis WCX. The limit of quantification (LOQ) of 0.05 mg/kg was reached for Gly and Glu;
0.1 mg/kg for AMPA. Recovery values ranged from 94% to 115% in depending of analyte and
concentration level. The RSD values were ranged from 3 to 15%. The correlation coefficients were
higher than 0.99. The method was applied in 2021-22 for analysis of tea samples, which revealed
about 82% of positives above LOQ level and about 38% of positives with concentrations more than
0.2 mg/kg. Three samples with concentrations of glyphosate between 1-1.07 mg/kg were found. The
glyphosate content in green tea was less in 3 times, in comparison with black tea.