bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Investigations on the Residual Performance of Earthquake-Damaged Low-Rise-Reinforced Concrete Shear Walls
Authors: Liao Wen-I , Zheng Yu-Ming
Published: March 2024

This study investigates the seismic residual performance of reinforced concrete (RC) shear walls with different levels of earthquake damage through reversed cyclic loading tests. The test specimens include slightly damaged walls, moderately damaged walls, and repaired specimens after moderately damaged walls. From the test and analysis results, it is evident that the residual strength and deformation capacity of slightly and moderately damaged RC shear walls do not decrease compared with the undamaged wall. However, the residual stiffness and energy dissipation capacity of damaged walls significantly decrease. The test results are also compared with the reduction factors for residual stiffness, strength, deformation capacity, and energy dissipation capacity in the FEMA 306 and JBDPA post-earthquake assessment guidelines to assess their applicability. Additionally, this study proposes a simplified model to describe residual lateral capacity curves of damaged RC walls at different damage levels for nonlinear pushover analysis, allowing engineers to easily convert the capacity curves of undamaged walls to damaged ones.
Fatigue Damage Analysis of Steel Truss Suspension Bridge Under Non-Stationary and Non-Gaussian Buffeting
Authors: Hu Jun , Zhang Xinqi , Tan Shaohua , Liang Yongyong , Wang Junhan
Published: March 2024

The wind field environment in mountainous zones is complex. If the wind field characteristics are regarded as stationary and Gaussian, the inaccurate response results of the structure will be obtained. In this paper, a fatigue evaluation method of steel truss suspension bridge members under non-stationary and non-Gaussian buffeting is proposed. This approach can solve the fatigue evaluation problem of steel truss suspension bridge members under mountain wind. Firstly, the normal wind speed (stationary and Gaussian) is obtained by the harmonic wave synthesis method. The wind speed considering non-stationary characteristics is obtained by adopting time-varying power spectrum. Secondly, through non-linear translation, the wind speed considering non-stationary characteristics is transformed into wind speed considering both non-Gaussian and non-stationary characteristics. Finally, combined with the Palmgren–Miner rule, the effects of three different buffeting responses on fatigue damage of suspension bridge members are studied. They are traditional buffeting response, buffeting response considering non-stationary characteristics and buffeting response considering both non-stationary and non-Gaussian characteristics. The results indicate that the fatigue damage of the main cable of the suspension bridge is the biggest at the mid-span. Under the same wind speed, considering two characteristics, the component fatigue damage will further increase.
Symmetric/Asymmetric Vibrational Characteristics of Bi-Directional Functionally Graded Annular Microplates
Authors: Liu Longbo , Gao Fangqing , Zhang Bo , Liu Juan , Yang Yukang , Deng Hexuan
Published: March 2024

In this study, a free vibration model of bi-directional functionally graded (BD-FG) annular microplates is established based on the modified couple stress theory (MCST) and the first-order shear deformation theory (FSDT), and the corresponding governing equations are derived from Hamilton’s principle. The annular microplates are assumed to be composed of metal and ceramic materials, and the equivalent material properties are a combination of power-law function and exponential ones. The generalized differential quadrature method (GDQM) is used to obtain the vibration frequencies and mode displacements for the C–C, S–C, C–S, and S–S (S: simply supported; C: clamped) annular microplates. The convergence and validity of the proposed model are verified through selective numerical examples. Further, the effects of gradient index, material length scale parameter, boundary conditions, and geometrical dimensions on the symmetric/asymmetric vibration frequencies of the annular microplate are explored. The modal assurance criterion is applied to estimate the influence of the radial gradient index and material length scale parameter on different-order mode displacements of the annular microplate. The results show that: (1) the vibration frequencies of the annular microplate are sensitive to changes in the geometry and boundary conditions; (2) compared with the axial gradient index, the radial gradient index not only affects the vibration frequencies of the annular microplate, but also impacts the distribution of the highest and lowest points of the vibration mode displacements as well as the vibration mode nodal lines; (3) as the material length scale parameter increases, the vibration frequencies are significantly increased, and the higher-order vibration modes of the annular microplate also change.
Blockchain-Based Lean Supply Chain: A Simulation Approach
Authors: Morelli Daniel Alexandre , Ignácio Paulo Sérgio de Arruda , Zanutim Nicholas Leonardi
Published: March 2024

This paper aims to propose a model based on blockchain and cloud computing technologies to support lean production techniques for industrial supply chain management, evaluating how the combination of these technologies provides improvement in the chain performance. The literature review contextualizes the state of the art in studies related to the application of blockchain technology to lean manufacturing processes, as well as identifies research gaps in this field. Besides, this study models and simulates an architecture based on both the Hyperledger Fabric network and a virtual machine in the cloud environment, assessing its applicability and performance in the industrial supply chain. The analysis addresses lean aspects identified as research gaps, including integration of stakeholders in the collaborative production of customized products, conditions of flexibility and adaptability to demand variations, coordinated relationship of networks involving small and medium-sized enterprises, and behavior of various players acting simultaneously and consensually. The proposed model reveals a decentralized and nonlinear information sharing concept that demonstrates a logic of simultaneous participation of all players involved in the supply chain. The low costs and processing times identified in the simulation indicate the robustness of the system even in transactions involving a large number of companies and a large amount of data. This architecture offers an integration solution between stakeholders to support operational processes, providing insights for researchers and specialists in the adoption of innovative, reliable and inclusive information technologies for companies of different sizes or levels of development, with a focus on lean manufacturing, reduction in resource consumption and cost reduction. The developed model, which combines blockchain and cloud computing technologies applied to stages of lean production systems, presents a differentiated solution on the planning of integrated production systems, indicating the differential in this work.
Type-2 Fuzzy Metric Spaces
Authors: Samanta Upasana
Published: March 2024

In this paper, an attempt is made to define a Type-2 fuzzy metric on a nonempty set [Formula: see text] by allowing it to take fuzzy numbers as values of distance of a pair of points under a membership grade which is also a fuzzy number. Its type-1 counterpart is a fuzzy metric mostly similar to those defined by Kramosil and Michalek [Formula: see text] and also by George and Veeramani [Formula: see text]. It is shown that the topology induced by this fuzzy metric is Hausdorff in nature. In this type of fuzzy metric space, Banach’s fixed point theorem and Edelstein’s fixed point theorems are extended. Finally decomposition theorems for this fuzzy metric are proved from which a justification of type-2 behavior of this fuzzy metric can also be interpreted.
Composite Molecular Sieve ZSM-5/MCM-48-Based Impregnation Modification for Efficient Adsorption of CO2
Authors: Ma Xuecong , Geng Linlin , Li Yu , Wei Jianwen , Liao Lei , Wang Dunqiu
Published: March 2024

Micro/mesoporous materials are low-cost functional materials with the potential for CO2 adsorption. Modifying micro/mesoporous materials is significant for enhancing CO2 adsorption and their high-value utilization. Herein, the micro/mesoporous material of composite molecular sieve ZSM-5/MCM-48 (ZM) was synthesized by a two-step crystallization method using cetyltrimethylammonium bromide as a template, tetraethyl orthosilicate as a silicon source and ZSM-5 seed as part of silicon aluminum source. Tetraethylenepentamine (TEPA) and polyethyleneimine (PEI) were used as impregnation modifiers to modify ZM with amine groups. The results showed that with the increase of amine loadings, both ZM-T60 (Impregnated with TEPA) and ZM-P60 (Impregnated with PEI) functionalized adsorbents exhibited the best adsorption capacities of [Formula: see text] and [Formula: see text] at 60, respectively, when the loading of ZM sample was 60%. The adsorption kinetic analysis showed that the adsorption of CO2 by ZM-T60 and ZM-P60 was a chemisorption-dominated process accompanied by physical adsorption. After 10 adsorption/desorption cycles, the CO2 adsorption capacity of ZM-T60 and ZM-P60 decreased by 8.7% and 2.6%, respectively. This work demonstrates that impregnation modification of the composite molecular sieve to achieve efficient CO2 adsorption has practical application significance.
Effects of Floating States on Collision Forces of Drifting Containers Caused by Solitary Wave Inundation
Authors: Hwang Taegeon , Kim Taeyoon , Kim Jiwon , Kim Yeonjoong , Lee Woo-Dong
Published: March 2024

The overtopping-inundation process of a tsunami results in the collisions of drifting objects on the coast, which damage structures, thereby increasing the risk of collapse. This study conducted laboratory experiments on the collision between a drifting container caused by the overtopping-inundation process of a solitary wave and a fixed port crane’s leg. The movement trajectory and velocity of the container as well as the collision velocity by solitary wave inundation, were analyzed using motion analysis software. Overall, increasing solitary wave scale, collision velocity, and drifting object weight and decreased distance between the two objects tended to increase the collision force. However, different experiment results were also obtained due to pitching in objects that fully floated without bottom friction owing to the solitary wave bore. This resulted in line-to-surface collisions. Thus, surface-to-surface contact occurred under the incomplete floating condition owing to the difficulty because of interference with the bottom; however, the collision force decreased under complete floating conditions owing to line-to-surface contact. Therefore, the contact condition according to the floating behavior must be considered a parameter while predicting the collision forces of drifting objects. Thus, surface-to-surface contact occurred under the incomplete floating condition owing to the difficulty because of interference with the bottom; however, the collision force decreased under complete floating conditions owing to line-to-surface contact. Therefore, the contact condition according to the floating behavior must be considered a parameter while predicting the collision forces of drifting objects.
IMPACTS OF GLOBAL WARMING ON REGIONAL ENERGY AND ECONOMY: UNEVEN CONSEQUENCES ARISING FROM GLOBAL WARMING-INDUCED HEATING AND COOLING DEMAND OF HOUSEHOLDS
Authors: MA LIN , WEI TAOYUAN , NORDLING KALLE , AAHEIM ASBJØRN
Published: March 2024

The impacts of global warming vary across regions. This paper studies the distributional implications of global warming impacts on household energy use for heating and cooling and the induced macroeconomic responses under different scenarios. Our research updates the direct impact of global warming on household energy demand in 140 regions worldwide by utilizing existing estimations of damage functions related to temperature changes. Subsequently, the updated direct impact is used in a global static computable general equilibrium (CGE) model to evaluate the macroeconomic responses. We find that at the global level, the market effects cause a reduction in the direct impact on the demand for oil and gas, while that for electricity displays a positive but moderate growth. Whereas the regional effects vary across countries and lead to changes in both directions, in which the autonomous adaptation embodied in the global market plays a vital role. Furthermore, we find strong inequality in the socioeconomic responses to global warming across regions. Notably, low-income countries are most strongly affected by increased primary energy use and decreased gross domestic product (GDP). Disparities in the impacts on carbon-based energy sources yield a near-perfect inequality as per the adjusted Gini index for CO2 emission changes, which potentially intensify the distributional consequences of global climate change.
Multi-agent DRL-based Multipath Scheduling for Video Streaming with QUIC
Authors: Han Xueqiang , Han Biao , Li Jinrong , Song Congxi
Published: March 2024

The popularization of video streaming brings challenges in satisfying diverse Quality of Service (QoS) requirements. The multipath extension of the Quick UDP Internet Connection (QUIC) protocol, also called MPQUIC, has the potential to improve video streaming performance with multiple simultaneously transmitting paths. The multipath scheduler of MPQUIC determines how to distribute the packets onto different paths. However, while applying current multipath schedulers into MPQUIC, our experimental results show that they fail to adapt to various receive buffer sizes of different devices and comprehensive QoS requirements of video streaming. These problems are especially severe under heterogeneous and dynamic network environments. To tackle these problems, we propose MARS, a Multi-agent deep Reinforcement learning (MADRL)-based Multipath QUIC Scheduler, which is able to promptly adapt to dynamic network environments. It exploits the MADRL method to learn a neural network for each path and generate scheduling policy. Besides, it introduces a novel multi-objective reward function that takes out-of-order queue size and different QoS metrics into consideration to realize adaptive scheduling optimization. We implement MARS in an MPQUIC prototype and deploy in Dynamic Adaptive Streaming over HTTP system. Then, we compare it with the state-of-the-art multipath schedulers in both emulated and real-world networks. Experimental results show that MARS outperforms the other schedulers with better adaptive capability regarding the receive buffer sizes and QoS.
Realizing Efficient On-Device Language-based Image Retrieval
Authors: Hu Zhiming , Kemertas Mete , Xiao Lan , Phillips Caleb , Mohomed Iqbal , Fazly Afsaneh
Published: March 2024

Advances in deep learning have enabled accurate language-based search and retrieval (e.g., over user photos) in the cloud. Many users prefer to store their photos in the home due to privacy concerns. As such, a need arises for models that can perform cross-modal search on resource-limited devices. State-of-the-art (SOTA) cross-modal retrieval models achieve high accuracy through learning entangled representations that enable fine-grained similarity calculation between a language query and an image, but at the expense of having a prohibitively high retrieval latency. Alternatively, there is a new class of methods that exhibits good performance with low latency but requires a lot more computational resources and an order of magnitude more training data (i.e., large web-scraped datasets consisting of millions of image–caption pairs), making them infeasible to use in a commercial context. From a pragmatic perspective, none of the existing methods are suitable for developing commercial applications for low-latency cross-modal retrieval on low-resource devices. We propose CrispSearch, a cascaded approach that greatly reduces the retrieval latency with minimal loss in ranking accuracy for on-device language-based image retrieval. The idea behind our approach is to combine a light-weight and runtime-efficient coarse model with a fine re-ranking stage. Given a language query, the coarse model effectively filters out many of the irrelevant image candidates. After this filtering, only a handful of strong candidates will be selected and sent to a fine model for re-ranking. Extensive experimental results with two SOTA models for the fine re-ranking stage on standard benchmark datasets show that CrispSearch results in a speedup of up to 38 times over the SOTA fine methods with negligible performance degradation. Moreover, our method does not require millions of training instances, making it a pragmatic solution to on-device search and retrieval.
DeepMeshCity: A Deep Learning Model for Urban Grid Prediction
Authors: Zhang Chi , Cai Linhao , Chen Meng , Li Xiucheng , Cong Gao
Published: March 2024

Urban grid prediction can be applied to many classic spatial-temporal prediction tasks such as air quality prediction, crowd density prediction, and traffic flow prediction, which is of great importance to smart city building. In light of its practical values, many methods have been developed for it and have achieved promising results. Despite their successes, two main challenges remain open: (a) how to well capture the global dependencies and (b) how to effectively model the multi-scale spatial-temporal correlations? To address these two challenges, we propose a novel method—
DeepMeshCity
, with a carefully-designed Self-Attention Citywide Grid Learner (
SA-CGL
) block comprising of a self-attention unit and a Citywide Grid Learner (
CGL
) unit. The self-attention block aims to capture the global spatial dependencies, and the
CGL
unit is responsible for learning the spatial-temporal correlations. In particular, a multi-scale memory unit is proposed to traverse all stacked
SA-CGL
blocks along a zigzag path to capture the multi-scale spatial-temporal correlations. In addition, we propose to initialize the single-scale memory units and the multi-scale memory units by using the corresponding ones in the previous fragment stack, so as to speed up the model training. We evaluate the performance of our proposed model by comparing with several state-of-the-art methods on four real-world datasets for two urban grid prediction applications. The experimental results verify the superiority of DeepMeshCity over the existing ones. The code is available at https://github.com/ILoveStudying/DeepMeshCity.
BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy
Authors: Martin Thomas G. , Sherer Laura A. , Kirk Jonathan A.
Published: March 2024

We report BAG3’s localization to mitochondria and its role in mitophagy for the first time in primary ventricular cardiac fibroblasts. We have also collected the first evidence showing that loss of BAG3 increases cardiac fibroblast activation into myofibroblasts, which are major drivers of cardiac fibrosis and pathological remodeling during heart disease.
Available Transfer Capability Assessment of Multiarea Power Systems with Conditional Generative Adversarial Network
Authors: Meng Xiangfei , Zhang Lina , Tian Xin , Chu Hongqing , Wang Yao , Shi Qingxin
Published: March 2024

Available transfer capability (ATC) is an important measurement index to evaluate the security margin of interconnected power grids and serve as a reference for the transmission right transaction. In modern power systems, ATC is affected by the transmission network topology, renewable power output uncertainty, and load demand uncertainty. Traditional works usually model the power source-load uncertainty by using robust optimization, interval optimization, or chance-constraint optimization, which cannot fully reflect the probabilistic distribution of the daily source-load uncertainty. This paper proposes an ATC assessment methodology based on the typical stochastic scenarios of renewable output and load demand of multiarea power systems. Furthermore, the conditional generative adversarial network (CGAN) algorithm is adopted to generate and select representative scenario sets based on historical raw data, which can fully reflect the usual operating condition of a system with high renewable energy penetration. The scenario set that is fed into the ATC assessment model can fully characterize the impact of source-load uncertainty on daily ATC. Finally, the proposed method is verified by a modified three-area IEEE 9-bus system and a real-world provincial power system.
A Rare Case of Acute Methotrexate Toxicity Leading to Bone Marrow Suppression
Authors: Khuwaja Samreen , Lyons Matthew , Zulfiqar Beenish
Published: March 2024

Methotrexate is a first‐line disease modifying antirheumatic drug used for the treatment of inflammatory arthritis. Bone marrow suppression is a common adverse reaction of methotrexate following its long‐term use. However, low dose methotrexate is rarely associated with life‐threatening bone marrow suppression. This case represents an atypical presentation of acute bone marrow suppression shortly after initiating treatment with low‐dose methotrexate. A 76‐year‐old male patient presented with oral ulcers, poor oral intake, and acute kidney injury within 3 weeks of initiating 15 mg weekly of methotrexate for seronegative rheumatoid arthritis. Complete blood count was suggestive of pancytopenia with hemoglobin of 10.8 g/dL, total white cell count 3.36 (1000/uL) (absolute neutrophil count 490 micro/L), platelets 19,000, serum albumin 3.1 g/dL, ESR elevated at 83 mm/hr, CRP elevated at 86.6 mg/L, and ferritin mildly elevated at 625 ng/mL. Peripheral blood smear showed signs of bone marrow suppression but no signs of hemolysis or inflammation. Serum methotrexate levels were minimally detectable at 0.05 umol/L. Methotrexate was held, within 48 hours of admission; his WBC dropped to 1.48, Hgb 9.9, and platelets 15,000. ANC reached a nadir of 220. He was treated with broad spectrum antibiotics, high‐dose folic acid, fluconazole for oral thrush, and intravenous bicarbonate and leucovorin supplementation, dosed at PO 20 mg daily. On day 7, his blood count showed improvement along with improvement in his symptoms. The patient was discharged home on day 8th of hospitalization and upon one month follow‐up in rheumatology clinic, his complete blood count had normalized. This case highlights multiple risk factors that triggered pancytopenia in our elderly patient, resulting in acute methotrexate toxicity.
Burst Failure Characteristics and Energy Evolution Law of Coal with Prefabricated Cracks at Different Angles
Authors: Zhang Xiufeng , Han Yueyong , Chen Yang , Ma Xingyin , Zhang Xinrong , Man Cao , Yin Yanchun
Published: March 2024

In order to study the influence of fissures on the burst tendency of coal, the test and numerical simulation of the burst tendency of coal with different burst angles were carried out. The evolution law of the burst tendency index of coal under the influence of burst angle was analyzed, and the mechanism of energy storage and release of coal under the influence of fissure angle was revealed. The results show that compared with the specimens without prefabricated cracks, the uniaxial compressive strength of the specimens with 0° cracks is reduced by 48.4%, the dynamic failure time is increased by 279.4%, the burst energy index is reduced by 54%, and the burst energy velocity index is reduced by 87.9%. After that, with the increase of prefabricated crack angle, the uniaxial compressive strength of coal increases gradually, the dynamic failure time decreases gradually, the burst energy index increases gradually, and the burst energy velocity index increases gradually. That is to say, the larger the crack angle contained in the coal body, the stronger the burst tendency of the coal body, but it is still lower than that of the complete coal body. With the increase of prefabricated crack angle, the proportion of prepeak elastic energy of coal body increases, the less energy dissipation in the whole loading process of coal body, and the faster energy release rate during failure. The research results can provide some theoretical support for the prevention and control of rock burst disaster.
Semisupervised Medical Image Segmentation through Prototype-Based Mutual Consistency Learning
Authors: Wang Xinqiang , Lu Wenhuan , Li Si , Zheng Ke , Xu Junhai , Wei Jianguo
Published: March 2024

Medical image segmentation is a critical task in the healthcare field. While deep learning techniques have shown promise in this area, they often require a large number of accurately labeled images. To address this issue, semisupervised learning has emerged as a potential solution by reducing the reliance on precise annotations. Among these approaches, the student-teacher framework has garnered attention, but it is limited in its reliance solely on the teacher model for information. To overcome this limitation, we propose a prototype-based mutual consistency learning (PMCL) framework. This framework utilizes two branches that learn from each other, incorporating supervision loss and consistency loss to adapt to minor data perturbations and structural differences. By employing prototype consistency learning, we are able to achieve reliable consistency loss. Our experiments on three public medical image datasets demonstrate that PMCL outperforms other state-of-the-art methods, indicating its potential in semisupervised medical image segmentation. Our framework has the potential to assist medical professionals in enhancing their diagnoses and delivering improved patient care.
Figure S6 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Authors: Martins Filipe , Rosspopoff Olga , Carlevaro-Fita Joana , Forey Romain , Offner Sandra , Planet Evarist , Pulver Cyril , Pak HuiSong , Huber Florian , Michaux Justine , Bassani-Sternberg Michal , Turelli Priscilla , Trono Didier
Published: March 2024

Related to Figure 6: ZNF587/417 depletion leads to cell-intrinsic inflammation.
Figure S3 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Authors: Martins Filipe , Rosspopoff Olga , Carlevaro-Fita Joana , Forey Romain , Offner Sandra , Planet Evarist , Pulver Cyril , Pak HuiSong , Huber Florian , Michaux Justine , Bassani-Sternberg Michal , Turelli Priscilla , Trono Didier
Published: March 2024

Related to Figure 3: ZNF587/417 depletion impairs lymphoma cell growth and viability.
Figure S1 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Authors: Martins Filipe , Rosspopoff Olga , Carlevaro-Fita Joana , Forey Romain , Offner Sandra , Planet Evarist , Pulver Cyril , Pak HuiSong , Huber Florian , Michaux Justine , Bassani-Sternberg Michal , Turelli Priscilla , Trono Didier
Published: March 2024

Related to Figure 1: A KZFP gene cluster as poor prognosis predictor in DLBCL.
Supplementary Movie S2 from AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
Authors: Huang Tzu-Ting , Chiang Chih-Yuan , Nair Jayakumar R. , Wilson Kelli M. , Cheng Ken , Lee Jung-Min
Published: March 2024

Movie S2
Supplementary Fig. S8 from AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
Authors: Huang Tzu-Ting , Chiang Chih-Yuan , Nair Jayakumar R. , Wilson Kelli M. , Cheng Ken , Lee Jung-Min
Published: March 2024

Supplementary Fig. S8
Table S2 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

stemness score
Supplementary Fig. S3 from AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
Authors: Huang Tzu-Ting , Chiang Chih-Yuan , Nair Jayakumar R. , Wilson Kelli M. , Cheng Ken , Lee Jung-Min
Published: March 2024

Supplementary Fig. S3
Figure S7 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S7
Figure S15 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S15
Figure S11 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S11
Figure S10 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S10
Data from Foretinib Is Effective in Acute Myeloid Leukemia by Inhibiting FLT3 and Overcoming Secondary Mutations That Drive Resistance to Quizartinib and Gilteritinib
Authors: Wang Peihong , Zhang Yvyin , Xiang Rufang , Yang Jie , Xu Yanli , Deng Tingfen , Zhou Wei , Wang Caixia , Xiao Xinhua , Wang Shunqing
Published: March 2024

Abstract
FLT3 internal tandem duplication (FLT3-ITD) mutations are one of the most prevalent somatic alterations associated with poor prognosis in patients with acute myeloid leukemia (AML). The clinically approved FLT3 kinase inhibitors gilteritinib and quizartinib improve the survival of patients with AML with FLT3-ITD mutations, but their long-term efficacy is limited by acquisition of secondary drug-resistant mutations. In this study, we conducted virtual screening of a library of 60,411 small molecules and identified foretinib as a potent FLT3 inhibitor. An integrated analysis of the BeatAML database showed that foretinib had a lower IC50 value than other existing FLT3 inhibitors in patients with FLT3-ITD AML. Foretinib directly bound to FLT3 and effectively inhibited FLT3 signaling. Foretinib potently inhibited proliferation and promoted apoptosis in human AML cell lines and primary AML cells with FLT3-ITD mutations. Foretinib also significantly extended the survival of mice bearing cell-derived and patient-derived FLT3-ITD xenografts, exhibiting stronger efficacy than clinically approved FLT3 inhibitors in treating FLT3-ITD AML. Moreover, foretinib showed potent activity against secondary mutations of FLT3-ITD that confer resistance to quizartinib and gilteritinib. These findings support the potential of foretinib for treating patients with AML with FLT3-ITD mutations, especially for those carrying secondary mutations after treatment failure with other FLT3 inhibitors.
Significance:
Foretinib exhibits superior efficacy to approved drugs in AML with FLT3-ITD mutations and retains activity in AML with secondary FLT3 mutations that mediate resistance to clinical FLT3 inhibitors.
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
Authors: Hwang Grace H. , Pazyra-Murphy Maria F. , Seo Hyuk-Soo , Dhe-Paganon Sirano , Stopka Sylwia A. , DiPiazza Marina , Sutter Nizhoni , Gero Thomas W. , Volkert Alison , Ombelets Lincoln , Dittemore Georgia , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Agar Nathalie Y.R. , Scott David A. , Segal Rosalind A.
Published: March 2024

Medulloblastoma is one of the most common malignant brain tumors of children, and 30% of medulloblastomas are driven by gain-of-function genetic lesions in the Sonic Hedgehog (SHH) signaling pathway. EYA1, a haloacid dehalogenase phosphatase and transcription factor, is critical for tumorigenesis and proliferation of SHH medulloblastoma (SHH-MB). Benzarone and benzbromarone have been identified as allosteric inhibitors of EYA proteins. Using benzarone as a point of departure, we developed a panel of 35 derivatives and tested them in SHH-MB. Among these compounds, DS-1–38 functioned as an EYA antagonist and opposed SHH signaling. DS-1–38 inhibited SHH-MB growth in vitro and in vivo, showed excellent brain penetrance, and increased the lifespan of genetically engineered mice predisposed to fatal SHH-MB. These data suggest that EYA inhibitors represent promising therapies for pediatric SHH-MB.

Significance:

Development of a benzarone derivative that inhibits EYA1 and impedes the growth of SHH medulloblastoma provides an avenue for improving treatment of this malignant pediatric brain cancer.
Supplementary Figure S3 from Monitoring Minimal Residual Disease in Patients with Multiple Myeloma by Targeted Tracking Serum M-Protein Using Mass Spectrometry (EasyM)
Authors: Fan Huishou , Wang Bing , Shi Lihui , Pan Ni , Yan Wenqiang , Xu Jingyu , Gong Lixin , Li Lingna , Liu Yuntong , Du Chenxing , Cui Jian , Zhu Guoqing , Deng Shuhui , Sui Weiwei , Xu Yan , Yi Shuhua , Hao Mu , Zou Dehui , Chen Xiequn , Qiu Lugui , An Gang
Published: March 2024

Sensitivity and specificity between EasyM and sFLC.
Supplementary Table S5 from The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide
Authors: Halabi Susan , Guo Siyuan , Park Joseph J. , Nanus David M. , George Daniel J. , Antonarakis Emmanuel S. , Danila Daniel Costin , Szmulewitz Russell Zelig , McDonnell Donald P. , Norris John D. , Lu Changxue , Luo Jun , Armstrong Andrew J.
Published: March 2024

Hazard Ratio of PFS by baseline HOXB13 status, (CellSearch) CTC, and EPIC AR-V7
Supplementary Table S4 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Primary antibody information
Supplementary Data 1 from An Immune Gene Expression Risk Score for Distant Metastases after Radiotherapy for Cervical Cancer
Authors: Lukovic Jelena , Pintilie Melania , Han Kathy , Fyles Anthony W. , Bruce Jeffrey P. , Quevedo Rene , Pugh Trevor J. , Fjeldbo Christina S. , Lyng Heidi , Milosevic Michael F.
Published: March 2024

Supplemental Tables
Supplementary Figure S6 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

NTX-301 monotherapy inhibits PDX tumor growth.
Supplementary Figure S1 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

OC cells are highly sensitive to NTX301 treatment.
Table S1 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Table S1. The sequence information of lentivirus and AAV.
Figure S3 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S3. Activated neuron promote microglial M2 polarization.
Figure S14 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S14. Levetiracetam inhibited the activated-neuron induced microglial M2 polarization in vivo.
Figure S11 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S11. ZC3H13 regulates the expression of DUSP9.
Supplementary Table S1 from Phase II Study of Durvalumab Immediately after Completion of Chemoradiotherapy in Unresectable Stage III Non–small Cell Lung Cancer: TORG1937 (DATE Study)
Authors: Nakamichi Shinji , Kubota Kaoru , Misumi Toshihiro , Kondo Tetsuro , Murakami Shuji , Shiraishi Yoshimasa , Imai Hisao , Harada Daijiro , Isobe Kazutoshi , Itani Hidetoshi , Takata Saori , Wakui Hiroshi , Misumi Yuki , Ikeda Satoshi , Asao Tetsuhiko , Furuya Naoki , Hosokawa Shinobu , Kobayashi Yumiko , Takiguchi Yuichi , Okamoto Hiroaki
Published: March 2024

Volume definition and procedures in the radiotherapy plan
Supplementary Table S1 from Characterization of Immunosuppressive Myeloid Cells in Merkel Cell Carcinoma: Correlation with Resistance to PD-1 Pathway Blockade
Authors: Tabachnick-Cherny Shira , Pulliam Thomas , Rodriguez Haroldo J. , Fan Xinyi , Hippe Daniel S. , Jones Daniel C. , Moshiri Ata S. , Smythe Kimberly S. , Kulikauskas Rima M. , Zaba Lisa C. , Paulson Kelly G. , Nghiem Paul
Published: March 2024

Antibodies information
Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
Authors: Dermawan Josephine K. , Chiang Sarah , Singer Samuel , Jadeja Bhumika , Hensley Martee L. , Tap William D. , Movva Sujana , Maki Robert G. , Antonescu Cristina R.
Published: March 2024

Purpose:

Leiomyosarcomas (LMS) are clinically and molecularly heterogeneous tumors. Despite recent large-scale genomic studies, current LMS risk stratification is not informed by molecular alterations. We propose a clinically applicable genomic risk stratification model.

Experimental Design:

We performed comprehensive genomic profiling in a cohort of 195 soft tissue LMS (STLMS), 151 primary at presentation, and a control group of 238 uterine LMS (ULMS), 177 primary at presentation, with at least 1-year follow-up.

Results:

In STLMS, French Federation of Cancer Centers (FNCLCC) grade but not tumor size predicted progression-free survival (PFS) or disease-specific survival (DSS). In contrast, in ULMS, tumor size, mitotic rate, and necrosis were associated with inferior PFS and DSS. In STLMS, a 3-tier genomic risk stratification performed well for DSS: high risk: co-occurrence of RB1 mutation and chr12q deletion (del12q)/ATRX mutation; intermediate risk: presence of RB1 mutation, ATRX mutation, or del12q; low risk: lack of any of these three alterations. The ability of RB1 and ATRX alterations to stratify STLMS was validated in an external AACR GENIE cohort. In ULMS, a 3-tier genomic risk stratification was significant for both PFS and DSS: high risk: concurrent TP53 mutation and chr20q amplification/ATRX mutations; intermediate risk: presence of TP53 mutation, ATRX mutation, or amp20q; low risk: lack of any of these three alterations. Longitudinal sequencing showed that most molecular alterations were early clonal events that persisted during disease progression.

Conclusions:

Compared with traditional clinicopathologic models, genomic risk stratification demonstrates superior prediction of clinical outcome in STLMS and is comparable in ULMS.
Supplementary Methods from Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models
Authors: Sahovaler Axel , Valic Michael S. , Townson Jason L. , Chan Harley H.L. , Zheng Mark , Tzelnick Sharon , Mondello Tiziana , Pener-Tessler Alon , Eu Donovan , El-Sayes Abdullah , Ding Lili , Chen Juan , Douglas Catriona M. , Weersink Robert , Muhanna Nidal , Zheng Gang , Irish Jonathan C.
Published: March 2024

All supplementary methods.
Pre-Participation Screenings Frequently Miss Occult Cardiovascular Conditions in Apparently Healthy Male Middle-Aged First-Time Marathon Runners
Authors: Laily Inarota , Wiggers Tom G.H. , van Steijn Niels , Bijsterveld Nick , Bakermans Adrianus J. , Froeling Martijn , van den Berg-Faay Sandra , de Haan Ferdinand H. , de Bruin-Bon Rianne H.A.C.M. , Boekholdt S. Matthijs , Planken R. Nils , Verhagen Evert , Jorstad Harald T.
Published: March 2024

Introduction: The optimal pre-participation screening strategy to identify athletes at risk for exercise-induced cardiovascular events is unknown. We therefore aimed to compare the American College of Sports Medicine (ACSM) and European Society of Cardiology (ESC) pre-participation screening strategies against extensive cardiovascular evaluations in identifying high-risk individuals among 35–50-year-old apparently healthy men. Methods: We applied ACSM and ESC pre-participation screenings to 25 men participating in a study on first-time marathon running. We compared screening outcomes against medical history, physical examination, electrocardiography, blood tests, echocardiography, cardiopulmonary exercise testing, and magnetic resonance imaging. Results: ACSM screening classified all participants as “medical clearance not necessary.” ESC screening classified two participants as “high-risk.” Extensive cardiovascular evaluations revealed ≥1 minor abnormality and/or cardiovascular condition in 17 participants, including three subjects with mitral regurgitation and one with a small atrial septal defect. Eleven participants had dyslipidaemia, six had hypertension, and two had premature atherosclerosis. Ultimately, three (12%) subjects had a serious cardiovascular condition warranting sports restrictions: aortic aneurysm, hypertrophic cardiomyopathy (HCM), and myocardial fibrosis post-myocarditis. Of these three participants, only one had been identified as “high-risk” by the ESC screening (for dyslipidaemia, not HCM) and none by the ACSM screening. Conclusion: Numerous occult cardiovascular conditions are missed when applying current ACSM/ESC screening strategies to apparently healthy middle-aged men engaging in their first high-intensity endurance sports event.
Combining Surgery, Radiotherapy, and Topical Chemotherapy to Prevent Primary Orbital Exenteration for Atypical Caruncular Melanoma: A Case Report
Authors: De Landsheer Cédric , Merlevede Valentien , Jacobs Celine , Van Dorpe Jo , De Zaeytijd Julie , Ninclaus Virginie G.S. , Roels Dimitri
Published: March 2024

Introduction: This case report demonstrates the possibility of successful eye and vision-sparing therapy for caruncular melanoma. Case Presentation: We present an atypical presentation of a caruncular melanoma. After excisional biopsy, residual flat conjunctival melanosis resolved using topical chemotherapy (5-fluorouracil), which was well tolerated. Relapse of the melanoma was treated with external beam radiotherapy, but the tumor grew despite treatment. Eighteen months after complete excision of the relapsed melanoma, the patient remains tumor-free while the eye and its function remain preserved. Conclusion: This case report suggests that aggressive eye-sparing therapy for caruncular melanoma combining surgery, adjuvant topical chemotherapy, and external beam radiotherapy, can be an alternative for primary orbital exenteration.
Management Consensus Guidelines for Hepatocellular Carcinoma: 2023 Update on Surveillance, Diagnosis, Systemic Treatment, and Posttreatment Monitoring by the Taiwan Liver Cancer Association and the Gastroenterological Society of Taiwan
Authors: Teng Wei , Wang Hung-Wei , Lin Shi-Ming ,   On behalf of Diagnosis Group and Systemic Therapy Group of TLCA
Published: March 2024

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality in Taiwan. The Taiwan Liver Cancer Association and the Gastroenterological Society of Taiwan established HCC management consensus guidelines in 2016 and updated them in 2023. Current recommendations focus on addressing critical issues in HCC management, including surveillance, diagnosis, systemic treatment, and posttreatment monitoring. For surveillance and diagnosis, we updated the guidelines to include the role of protein induced by vitamin K absence or antagonist II (PIVKA-II) and gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) in detecting HCCs. For systemic treatment, the updated guidelines summarize the multiple choices available for targeted therapy, immune checkpoint inhibitors, and a combination of both, especially for those carcinomas refractory to or unsuitable for transarterial chemoembolization. We have added a new section, posttreatment monitoring, that describes the important roles of PIVKA-II and EOB-MRI after HCC therapy, including surgery, locoregional therapy, and systemic treatment. Through this update of the management consensus guidelines, patients with HCC may benefit from optimal diagnosis, therapeutic modalities, and posttreatment monitoring.
Double Myelomeningocele Repair by Fetal Surgery with a Single Micro-Hysterotomy
Authors: Chavelas-Ochoa Felipe , Bermúdez-Rojas Ma de la Luz , Medina-Jiménez Virginia , Helue-Mena Antonio , Gil-Pugliese Savino , Gutiérrez-Gómez Ivan , Martínez-Rodríguez Miguel , Gaona-Tapia Carmen Julia , Villalobos-Gómez Rosa , Aguilar-Vidales Karla , Cruz-Martínez Rogelio
Published: March 2024

Introduction: Open spina bifida (OSB) is the most common congenital anomaly of the central nervous system. It is associated with severe neurodevelopmental delay, motor impairment, hydrocephalus, and bowel and bladder dysfunction. In selected cases, intrauterine spina bifida repair has been shown to improve neonatal outcomes. Rarely, the spine can have a double defect compromising two different segments and there is a lack of evidence on the feasibility and benefits of intrauterine repair in these cases. Case Presentation: We present a case with both cervicothoracic and lumbosacral myelomeningocele, Arnold-Chiari malformation type II and bilateral ventriculomegaly, that was treated successfully at 25 weeks with open micro-neurosurgery. Double myelomeningocele was successfully treated through a single 2-cm micro-hysterotomy, by performing external versions to sequentially expose and repair both defects. Weekly postoperative follow-up showed no progression of ventriculomegaly or complications attributable to the procedure. Preterm rupture of membranes prompted a conventional cesarean delivery at 32 weeks of gestation. Neurodevelopmental outcome at 20 months was within normal ranges, having achieved ambulation without orthopedic support and with no need for ventriculoperitoneal shunting. Conclusion: This report demonstrates for the first time the feasibility of double OSB repair through a single 2-cm micro-hysterotomy, suggesting that selected isolated cases of double myelomeningocele could be candidates for fetal intervention. Further prospective studies should be carried out to assess the potential benefit of double OSB intrauterine open repair.