bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitral Valve Surgery in Patients With Rheumatic Heart Disease: Repair vs. Replacement
Authors: Fu Guangguo , Zhou Zhuoming , Huang Suiqing , Chen Guangxian , Liang Mengya , Huang Lin , Wu Zhongkai
Published: May 2021

Background: High morbidity and mortality caused by rheumatic heart disease (RHD) are global burdens, especially in low-income and developing countries. Whether mitral valve repair (MVP) benefits RHD patients remains controversial. Thus, we performed a meta-analysis to compare the perioperative and long-term outcomes of MVP and mitral valve replacement (MVR) in RHD patients.

Methods and Results: A systematic literature search was conducted in major databases, including Embase, PubMed, and the Cochrane Library, until 17 December 2020. Studies comparing MVP and MVR in RHD patients were retained. Outcomes included early mortality, long-term survival, freedom from reoperation, postoperative infective endocarditis, thromboembolic events, hemorrhagic events, and freedom from valve-related adverse events. Eleven studies that met the inclusion criteria were included. Of a total of 5,654 patients, 1,951 underwent MVP, and 3,703 underwent MVR. Patients who undergo MVP can benefit from a higher long-term survival rate (HR 0.72; 95% CI, 0.55–0.95; P = 0.020; I2 = 44%), a lower risk of early mortality (RR 0.62; 95% CI, 0.38–1.01; P = 0.060; I2 = 42%), and the composite outcomes of valve-related adverse events (HR 0.60; 95% CI, 0.38–0.94; P = 0.030; I2 = 25%). However, a higher risk of reoperation was observed in the MVP group (HR 2.60; 95% CI, 1.89–3.57; P<0.001; I2 = 4%). Patients who underwent concomitant aortic valve replacement (AVR) in the two groups had comparable long-term survival rates, although the trend still favored MVP.

Conclusions: For RHD patients, MVP can reduce early mortality, and improve long-term survival and freedom from valve-related adverse events. However, MVP was associated with a higher risk of reoperation.

Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=228307.
Estimating Exposure Risk to Guide Behaviour During the SARS-COV2 Pandemic
Authors: Smyth Barry
Published: May 2021

The end of 2020 and the beginning of 2021 was a challenging time for many countries in Europe, as the combination of colder weather, holiday celebrations, and the emergence of more transmissible virus variants conspired to create a perfect storm for virus transmission across the continent. At the same time lockdowns appeared to be less effective than they were earlier in the pandemic. In this paper we argue that one contributing factor is that existing ways of communicating risk—case numbers, test positivity rates, hospitalisations etc.—are difficult for individuals to translate into a level of personal risk, thereby limiting the ability of individuals to properly calibrate their own behaviour. We propose an new more direct measure of personal risk, exposure risk, to estimate the likelihood that an individual will come into contact with an infected person, and we argue that it can play an important role, alongside more conventional statistics, to help translate complex epidemiological data into a simple measure to guide pandemic behaviour. We describe how exposure risk can be calculated using existing data and infection prediction models, and use it to evaluate and compare the exposure risk associated with 39 European countries.
Accounting for Natural Uncertainty Within Monitoring Systems for Induced Seismicity Based on Earthquake Magnitudes
Authors: Roy Corinna , Nowacki Andy , Zhang Xin , Curtis Andrew , Baptie Brian
Published: May 2021

To reduce the probability of future large earthquakes, traffic light systems (TLSs) define appropriate reactions to observed induced seismicity depending on each event's range of local earthquake magnitude (ML). The impact of velocity uncertainties and station site effects may be greater than a whole magnitude unit of ML, which can make the difference between a decision to continue (“green” TLS zone) and an immediate stop of operations (“red” zone). We show how to include these uncertainties in thresholds such that events only exceed a threshold with a fixed probability. This probability can be set by regulators to reflect their tolerance to risk. We demonstrate that with the new TLS, a red-light threshold would have been encountered earlier in the hydraulic fracturing operation at Preston New Road, UK, halting operations and potentially avoiding the later large magnitude events. It is therefore critical to establish systems which permit regulators to account for uncertainties when managing risk.
888–444 Ma Global Plate Tectonic Reconstruction With Emphasis on the Formation of Gondwana
Authors: Vérard Christian
Published: May 2021

The formation of Gondwana results from a complex history, which can be linked to many orogenic sutures. The sutures have often been gathered in the literature under broad orogenies — in particular the Eastern and Western Pan-African Orogenies — although their ages may vary a lot within those wide belts. ThePanalesismodel is a plate tectonic model, which aims at reconstructing 100% of the Earth’s surface, and proposes a geologically, geometrically, kinematically, and geodynamically coherent solution for the evolution of the Earth from 888 to 444 Ma. Although the model confirms that the assembly of Gondwana can be considered complete after the Damara and Kuunga orogenies, it shows above all that the detachment and amalgamation of “terranes” is a roughly continuous process, which even persisted after the Early Cambrian. By using the wealth of Plate Tectonics, thePanalesismodel makes it possible to derive numerous additional data and maps, such as the age of the sea-floor everywhere on the planet at every time slice, for instance. The evolution of accretion rates at mid-oceanic ridges and subduction rates at trenches are shown here, and yields results consistent with previous estimates. Understanding the variation of the global tectonic activity of our planet through time is key to link plate tectonic modeling with other disciplines of Earth sciences.
Anatomy of a Catastrophe: Reconstructing the 1936 Rock Fall and Tsunami Event in Lake Lovatnet, Western Norway
Authors: Waldmann Nicolas , Vasskog Kristian , Simpson Guy , Chapron Emmanuel , Støren Eivind Wilhelm Nagel , Hansen Louise , Loizeau Jean-Luc , Nesje Atle , Ariztegui Daniel
Published: May 2021

Rock falls and landslides plunging into lakes or small reservoirs can result in tsunamis with extreme wave run-ups. The occurrence of these natural hazards in populated areas have encouraged a recent sharp increase of studies that aim to mitigate their impact on human lives and assess infrastructure lost. This paper amalgamates in a novel fashion and at an unprecedented detail in situ historic measurements, geological data and numerical modeling of a rock fall event and associated tsunami wave that occurred in Lake Lovatnet (western Norway) in September 1936. Historical records report an event that released ca. 1 million m3 of rocks and debris from Ramnefjellet Mountain at an altitude of 800 m above Lake Lovatnet. The fragmented material plunged into the lake, causing a tsunami that reached a maximum run-up of 74 m and killed 74 people. In fact, the settlements of Bødal and Nesdal were wiped out as a result of the catastrophic wave. Sediments resulting from the 1936 rock fall and associated tsunami were identified in the subsurface of Lake Lovatnet by shallow geophysical investigations and were retrieved using gravity coring equipment. A set of high resolution physical and geochemical measurements were carried out on the cores with the aim of reproducing a highly detailed reconstruction of this catastrophic event in order to better understand and learn about the processes involved. The cores were retrieved in the northwestern sub-basin of the lake and its chronology was constrained by 210Pb and radiocarbon dating. A specially tailored physically based mathematical model was applied to better understand the tsunami event. Integration of the geophysical record, the sedimentological data and numerical modeling provide a comprehensive background to better understand the effects of such event in a deep fjord-like lacustrine basin and to generate information for better mitigation of similar events elsewhere.
Feedback That Leads to Improvement in Student Essays: Testing the Hypothesis that “Where to Next” Feedback is Most Powerful
Authors: Hattie John , Crivelli Jill , Van Gompel Kristin , West-Smith Patti , Wike Kathryn
Published: May 2021

Feedback is powerful but variable. This study investigates which forms of feedback are more predictive of improvement to students’ essays, using Turnitin Feedback Studio–a computer augmented system to capture teacher and computer-generated feedback comments. The study used a sample of 3,204 high school and university students who submitted their essays, received feedback comments, and then resubmitted for final grading. The major finding was the importance of “where to next” feedback which led to the greatest gains from the first to the final submission. There is support for the worthwhileness of computer moderated feedback systems that include both teacher- and computer-generated feedback.
Perspectives of Open-Air Processing to Enable Perovskite Solar Cell Manufacturing
Authors: Rolston Nicholas , Sleugh Andrew , Chen Justin P. , Zhao Oliver , Colburn Thomas W. , Flick Austin C. , Dauskardt Reinhold H.
Published: May 2021

We report high throughput open-air processing techniques for the scalable production of all device and barrier layers for perovskite photovoltaics (PV). This work discusses and resolves some of the most formidable barriers to module-level scaling that the perovskite community has been facing. Our advanced technoeconomic manufacturing analysis indicates that vacuum-based processes with high capital expenditures (CapEx) and low throughputs dominate the cost of production. Open-air fabrication methods offer low CapEx routes to manufacturing, but achieving reproducibility in ambient conditions with varying relative humidity has been a persistent challenge. The use of rapid processing methods with plasma curing to convert films from the solution-state enables reproducibility, moisture immunity, and the highest perovskite PV efficiency produced in open-air. These methods are readily translatable to in-line processing where layers are sequentially deposited without the need for lengthy post-annealing steps that reduce throughput and involve additional equipment. Significant progress is demonstrated in reduced manufacturing costs as perovskites contend as a commercially viable next-generation thin film PV technology.
Did COVID-19 Impact the Connectedness Between Green Bonds and Other Financial Markets? Evidence From Time-Frequency Domain With Portfolio Implications
Authors: Naeem Muhammad Abubakr , Mbarki Imen , Alharthi Majed , Omri Abdelwahed , Shahzad Syed Jawad Hussain
Published: May 2021

COVID-19 has morphed from a health crisis to an economic crisis that affected the global economy through several channels. This paper aims to study the impact of COVID-19 on the time-frequency connectedness between Green Bonds and other financial assets. Our sample includes the global stock market, bond market, oil, USD index, and two popular hedging alternatives, namely Gold and Bitcoin, from May 2013 to August 2020. First, we apply the methodologies of Diebold and Yilmaz (International Journal of Forecasting, 2012, 28(1), 57–66) and Baruník and Křehlík (Journal of Financial Econometrics, 2018, 16(2), 271–296). Then, we estimate hedge ratios and hedge effectiveness of green bonds for other financial assets. Green bonds are found to have a great weight in the overall network, particularly strongly connected with the USD index and bond index. While the bi-directional relationship with USD persists during COVID, the connectedness with conventional bonds is also strengthened. Notably, we find a weak relationship between Green bonds and Bitcoin, both in the short and long run. As portfolio implications, Gold and USD have the highest hedge ratio, which is confirmed by the hedging effectiveness. In contrast, oil and stocks exhibit the lowest hedging effectiveness. Our findings imply that financial assets might have a heterogeneous relationship with green bonds. Furthermore, despite its infancy, it seems that the role of green bond during a crisis should not be ignored, as it can be a hedger for some assets, while a contagion amplifier during crisis times.
Physisorption and Chemisorption Mechanisms Influencing Micro (Nano) Plastics-Organic Chemical Contaminants Interactions: A Review
Authors: Agboola Omowumi D. , Benson Nsikak U.
Published: May 2021

Microplastics, which serve as sources and vector transport of organic contaminants in both terrestrial and marine environments, are emerging micropollutants of increasing concerns due to their potential harmful impacts on the environment, biota and human health. Microplastic particles have a higher affinity for hydrophobic organic contaminants due to their high surface area-to-volume ratio, particularly in aqueous conditions. However, recent findings have shown that the concentrations of organic contaminants adsorbed on microplastic surfaces, as well as their fate through vector distribution and ecological risks, are largely influenced by prevailing environmental factors and physicochemical properties in the aquatic environment. Therefore, this review article draws on scientific literature to discuss inherent polymers typically used in plastics and their affinity for different organic contaminants, as well as the compositions, environmental factors, and polymeric properties that influence their variability in sorption capacities. Some of the specific points discussed are (a) an appraisal of microplastic types, composition and their fate and vector transport in the environment; (b) a critical assessment of sorption mechanisms and major polymeric factors influencing organic contaminants-micro (nano) plastics (MNPs) interactions; (c) an evaluation of the sorption capacities of organic chemical contaminants to MNPs in terms of polymeric sorption characteristics including hydrophobicity, Van der Waals forces, π–π bond, electrostatic, and hydrogen bond interactions; and (d) an overview of the sorption mechanisms and dynamics behind microplastics-organic contaminants interactions using kinetic and isothermal models. Furthermore, insights into future areas of research gaps have been highlighted.
Explore the Underlying Mechanism Between Atopic Dermatitis and Major Depressive Disorder
Authors: Yang Tao , Huang Xuehua , Xu Jiajun , Situ Mingjing , Xiao Qingqing , Kural Kamil Can , Kang Yan
Published: May 2021

Adult patients with atopic dermatitis (AD) present relatively higher rates of major depressive disorder (MDD). However, the underlying mechanism is largely unknown. Here, we first conducted a systematic literature-based data mining to identify entities linking AD and MDD, including proteins, cells, functional classes, and small molecules. Then we conducted an AD-RNA expression data-based mega-analysis to test the expression variance of the genes that were regulators of MDD. After that, a Fisher Exact test-based pathway enrichment analysis (PEA) was performed to explore the AD-driven MDD-genetic regulators’ functionality. We identified 22 AD-driven entities that were up-stream MDD regulators, including 11 genes, seven small molecules, three functional classes, and one cell. AD could exert a promoting effect on the development of MDD. Four of the 11 genes demonstrated significant expression changes in AD patients in favor of the development of MDD. PEA results showed that AD mainly drives cytokine/chemokine regulation and neuroinflammatory response-related pathways to influence the pathological development of MDD. Our results supported the promotion role of AD in the pathological development of MDD, including the regulation of multiple genetic regulators of MDD involved in cytokine/chemokine regulation and inflammatory response.
Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration
Authors: Chen Huating , Li Gongchi , Liu Yiqiong , Ji Shuaifei , Li Yan , Xiang Jiangbing , Zhou Laixian , Gao Huanhuan , Zhang Wenwen , Sun Xiaoyan , Fu Xiaobing , Li Binghui
Published: May 2021

Wound healing is a multi-step process that includes multiple cellular events such as cell proliferation, cell adhesion, and chemotactic response as well as cell apoptosis. Accumulating studies have documented the significance of stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 (CXCR4) signaling in wound repair and regeneration. However, the molecular mechanism of regeneration is not clear. This review describes various types of tissue regeneration that CXCR4 participates in and how the efficiency of regeneration is increased by CXCR4 overexpression. It emphasizes the pleiotropic effects of CXCR4 in regeneration. By delving into the specific molecular mechanisms of CXCR4, we hope to provide a theoretical basis for tissue engineering and future regenerative medicine.
Creep and Recovery Behaviors of Lithium-Based Magnetorheological Grease
Authors: Ye Xudan , Wang Jiong
Published: May 2021

This article studies the creep and recovery behavior of magnetorheological grease (MRG) under constant stress shear. The experiment is done by using a parallel plate rheometer with magnetron attachment and temperature control unit. The effects of constant stress, CI particle concentration, magnetic flux density and temperature on creep and recovery behavior are systematically studied. Experimental results show that as the constant stress increases, the response strain will also increase. The creep strain tested under zero field is higher than the value tested under a magnetic field, indicating that the creep and recovery behavior of MRG is highly dependent on the magnetic field strength. In addition, the creep and recovery behavior of MRG is greatly affected by temperature. Under the action of a magnetic flux density, the creep strain will decrease with the increase of temperature. The result is opposite at zero magnetic field.
Effects of Sub-Lethal High Pressure Homogenization Treatment on the Adhesion Mechanisms and Stress Response Genes in Lactobacillus acidophilus 08
Authors: Braschi Giacomo , D’Alessandro Margherita , Gottardi Davide , Siroli Lorenzo , Patrignani Francesca , Lanciotti Rosalba
Published: May 2021

Cell surface hydrophobicity (CSH) and adhesion are very important phenotypical traits for probiotics that confer them a competitive advantage for the resilience in the human gastrointestinal tract. This study was aimed to understand the effects over time of a 50 MPa hyperbaric treatment on the surface properties of Lactobacillus acidophilus 08 including CSH, autoaggregation, and in vitro adhesion (mucin layer and Caco-2 cells). Moreover, a link between the hurdle applied and the expression of genes involved in the general stress response (groEL and clpP) and adhesion processes (efTu and slpA) was evaluated. High pressure homogenization (HPH) at 50 MPa significantly increased the CSH percentage (H%), autoaggregation and in vitro adhesion on mucin of L. acidophilus 08 cells compared with the untreated cells. Moreover, the hyperbaric hurdle induced an upregulation of the stress response genes groEL and ef-TU together with a down regulation of the clpP and S-layer slpA genes. Looking at the protein profile, HPH-treatment showed an increase in the number or intensity of protein bands at high and low molecular weights.
Neonatal Murine Model of Coxsackievirus A2 Infection for the Evaluation of Antiviral Therapeutics and Vaccination
Authors: Ji Wangquan , Qin Luwei , Tao Ling , Zhu Peiyu , Liang Ruonan , Zhou Guangyuan , Chen Shuaiyin , Zhang Weiguo , Yang Haiyan , Duan Guangcai , Jin Yuefei
Published: May 2021

Coxsackievirus (CV) A2 has emerged as an important etiological agent in the pathogen spectrum of hand, foot, and mouth disease (HFMD). The symptoms of CVA2 infections are generally mild, but worsen rapidly in some people, posing a serious threat to children’s health. However, compared with enterovirus 71 detected frequently in fatal cases, limited attention has been paid to CVA2 infections because of its benign clinical course. In the present study, we identified three CVA2 strains from HFMD infections and used the cell-adapted CVA2 strain HN202009 to inoculate 5-day-old BALB/c mice intramuscularly. These mice developed remarkably neurological symptoms such as ataxia, hind-limb paralysis, and death. Histopathological determination showed neuronophagia, pulmonary hemorrhage, myofiberlysis and viral myocarditis. Viral replication was detected in multiple organs and tissues, and CVA2 exhibited strong tropism to muscle tissue. The severity of illness was associated with abnormally high levels of inflammatory cytokines, including interleukin (IL)-6, IL-10, tumor necrosis factor α, and monocyte chemotactic protein 1, although the blockade of these proinflammatory cytokines had no obvious protection. We also tested whether an experimental formaldehyde-inactivated CVA2 vaccine could induce protective immune response in adult mice. The CVA2 antisera from the vaccinated mice were effective against CVA2 infection. Moreover, the inactivated CVA2 vaccine could successfully generate immune protection in neonatal mice. Our results indicated that the neonatal mouse model could be a useful tool to study CVA2 infection and to develop CVA2 vaccines.
Establishment of Novel Prostate Cancer Risk Subtypes and A Twelve-Gene Prognostic Model
Authors: Zhang Enchong , Shiori Fujisawa , Zhang Mo , Wang Peng , He Jieqian , Ge Yuntian , Song Yongsheng , Shan Liping
Published: May 2021

Prostate cancer (PCa) is the most common malignancy among men worldwide. However, its complex heterogeneity makes treatment challenging. In this study, we aimed to identify PCa subtypes and a gene signature associated with PCa prognosis. In particular, nine PCa-related pathways were evaluated in patients with PCa by a single-sample gene set enrichment analysis (ssGSEA) and an unsupervised clustering analysis (i.e., consensus clustering). We identified three subtypes with differences in prognosis (Risk_H, Risk_M, and Risk_L). Differences in the proliferation status, frequencies of known subtypes, tumor purity, immune cell composition, and genomic and transcriptomic profiles among the three subtypes were explored based on The Cancer Genome Atlas database. Our results clearly revealed that the Risk_H subtype was associated with the worst prognosis. By a weighted correlation network analysis of genes related to the Risk_H subtype and least absolute shrinkage and selection operator, we developed a 12-gene risk-predicting model. We further validated its accuracy using three public datasets. Effective drugs for high-risk patients identified using the model were predicted. The novel PCa subtypes and prognostic model developed in this study may improve clinical decision-making.
Induced Pluripotent Stem Cells for Ischemic Stroke Treatment
Authors: Duan Ranran , Gao Yang , He Ruya , Jing Lijun , Li Yanfei , Gong Zhe , Yao Yaobing , Luan Tingting , Zhang Chaopeng , Li Li , Jia Yanjie
Published: May 2021

Ischemic stroke is one of the main central nervous system diseases and is associated with high disability and mortality rates. Recombinant tissue plasminogen activator (rt-PA) and mechanical thrombectomy are the optimal therapies available currently to restore blood flow in patients with stroke; however, their limitations are well recognized. Therefore, new treatments are urgently required to overcome these shortcomings. Recently, stem cell transplantation technology, involving the transplantation of induced pluripotent stem cells (iPSCs), has drawn the interest of neuroscientists and is considered to be a promising alternative for ischemic stroke treatment. iPSCs are a class of cells produced by introducing specific transcription factors into somatic cells, and are similar to embryonic stem cells in biological function. Here, we have reviewed the current applications of stem cells with a focus on iPSC therapy in ischemic stroke, including the neuroprotective mechanisms, development constraints, major challenges to overcome, and clinical prospects. Based on the current state of research, we believe that stem cells, especially iPSCs, will pave the way for future stroke treatment.
Proteomic Analysis Reveals That Placenta-Specific Protein 9 Inhibits Proliferation and Stimulates Motility of Human Bronchial Epithelial Cells
Authors: Wang Hai-Xia , Qin Xu-Hui , Shen Jinhua , Liu Qing-Hua , Shi Yun-Bo , Xue Lu
Published: May 2021

Placenta-specific protein 9 (PLAC9) is a putative secretory protein that was initially identified in the placenta and is involved in cell proliferation and motility. Bioinformatics analyses revealed that PLAC9 is repressed in lung cancers (LCs), especially lung adenocarcinomas, compared to that in the paired adjacent normal tissues, indicating that PLAC9 might be involved in the pathogenesis of pulmonary diseases. To investigate the potential role of PLAC9 in the abnormal reprogramming of airway epithelial cells (AECs), a key cause of pulmonary diseases, we constructed a stable PLAC9-overexpressing human bronchial epithelial cell line (16HBE-GFP-Plac9). We utilized the proteomic approach isobaric tag for relative and absolute quantification (iTRAQ) to analyze the effect of PLAC9 on cellular protein composition. Gene ontology (GO) and pathway analyses revealed that GO terms and pathways associated with cell proliferation, cell cycle progression, and cell motility and migration were significantly enriched among the proteins regulated by PLAC9. Our in vitro results showed that PLAC9 overexpression reduced cell proliferation, altered cell cycle progression, and increased cell motility, including migration and invasion. Our findings suggest that PLAC9 inhibits cell proliferation through S phase arrest by altering the expression levels of cyclin/cyclin-dependent kinases (CDKs) and promotes cell motility, likely via the concerted actions of cyclins, E-cadherin, and vimentin. Since these mechanisms may underlie PLAC9-mediated abnormal human bronchial pathogenesis, our study provides a basis for the development of molecular targeted treatments for LCs.
Tissue-Based Biomarkers for the Risk Stratification of Men With Clinically Localized Prostate Cancer
Authors: Basourakos Spyridon P. , Tzeng Michael , Lewicki Patrick J. , Patel Krishnan , Al Hussein Al Awamlh Bashir , Venkat Siv , Shoag Jonathan E. , Gorin Michael A. , Barbieri Christopher E. , Hu Jim C.
Published: May 2021

Risk stratification of men with clinically localized prostate cancer has historically relied on basic clinicopathologic parameters such as prostate specific antigen level, grade group, and clinical stage. However, prostate cancer often behaves in ways that cannot be accurately predicted by these parameters. Thus, recent efforts have focused on developing tissue-based genomic tests that provide greater insights into the risk of a given patient’s disease. Multiple tests are now commercially available and provide additional prognostic information at various stages of the care pathway for prostate cancer. Indeed, early evidence suggests that these assays may have a significant impact on patient and physician decision-making. However, the impact of these tests on oncologic outcomes remains less clear. In this review, we highlight recent advances in the use of tissue-based biomarkers in the treatment of prostate cancer and identify the existing evidence supporting their clinical use.
National School-Based Health Lifestyles Intervention in Chinese Children and Adolescents on Obesity and Hypertension
Authors: Dong Yanhui , Zou Zhiyong , Wang Haijun , Dong Bin , Hu Peijin , Ma Yinghua , Song Yi , Ma Jun
Published: May 2021

Introduction:This study aimed to examine the effectiveness of the national school-based intervention on both obesity and high blood pressure in Chinese children and adolescents aged 6–18 years.

Methods:The national school-based cluster non-randomized controlled trial was done in seven provinces from September 2013 to February 2014. A total of 23,175 children and adolescents in the control group and 25,702 in the intervention group were included in this trial with a mean follow-up of 6.7 ± 0.9 months. Mixed-effects regression models were used to evaluate the effect of the interventions on body weight and blood pressure (BP).

Results:A significant upward in the body mass index (BMI) levels but downward in systolic BP (SBP), diastolic BP (DBP), BMIZ-scores, SBP Z-scores, and DBPZ-scores were witnessed in the intervention group compared to those in the control group (<0.001). Subgroup analyses presented significant intervention effects in children aged 6–12 years for BMI, SBP, DBP, and their standardized valuesZ-scores, but no effective results were found in adolescents aged 13–18 years. Stratification analyses based on the dynamic weight changes presented non-differential HBP, SHBP, and DHBP prevalence gaps between the control and intervention groups. Children aged 6–12 years with higher BMI percentiles at baseline presented obvious declines in SBP and DBP standardized valuesZ-scores.

Conclusion:A mean 6-month multi-centered school-based comprehensive obesity intervention in China yields a small to null effect on obesity and hypertension with increasing age; the early age before 12 years may be the key period for interventions, and the younger, the better. Precise and high-intensity interventions targeting the population at different stages of childhood and adolescence are urgently needed to be developed.

Clinical Trial Registration:https://www.clinicaltrials.gov/, identifier: NCT02343588
Reference Charts for Neonatal Cranial Volume Based on 3D Laser Scanning to Monitor Head Growth
Authors: Vermeulen Marijn Jorien , Burkhardt Wolfram , Fritze Anne , Roelants Jorine , Mense Lars , Willemsen Sten , Rüdiger Mario
Published: May 2021

Background: Postnatal brain growth is an important predictor of neurodevelopmental outcome in preterm infants. A new reliable proxy for brain volume is cranial volume, which can be measured routinely by 3-D laser scanning. The aim of this study was to develop reference charts for normal cranial volume in newborn infants at different gestational ages starting from late preterm for both sexes.

Methods: Cross-sectional cohort study in a German university hospital, including singleton, clinically stable, neonates born after 34 weeks of gestation. Cranial volume was measured in the first week of life by a validated 3-D laser scanner. Cranial volume data was modeled to calculate percentile values by gestational age and birth weight and to develop cranial volume reference charts for girls and boys separately.

Results: Of the 1,703 included infants, 846 (50%) were female. Birth weights ranged from 1,370 to 4,830 grams (median 3,370). Median cranial volume ranged from 320 [interquartile range (IQR) 294–347] ml at 34 weeks to 469 [IQR 442–496] ml at 42 weeks and was higher in boys than in girls.

Conclusions: This study presents the first reference charts of cranial volume which can be used in clinical practice to monitor brain growth between 34 and 42 weeks gestation in infants.
Mandatory Infant Vaccinations in France During the COVID-19 Pandemic in 2020
Authors: Taine Marion , Offredo Lucile , Drouin Jérôme , Toubiana Julie , Weill Alain , Zureik Mahmoud , Dray-Spira Rosemary
Published: May 2021

Objectives: To describe changes in the dispensation of 11 mandatory vaccines to infants in France during the COVID-19 pandemic in 2020, considering the priming doses and boosters separately.

Methods: With data from the French national health database, all dispensations of priming doses and boosters of 11 mandatory vaccines [penta/hexavalent, measles mumps rubella (MMR), meningococcal conjugate type-C (Men-C-C), 13-valent pneumococcal conjugate (PCV13)] for infants ≤24 months old were aggregated by 4-week periods in 2020. Expected counts in 2020 were estimated according to counts in 2019 weighted by a ratio considering the level of vaccine dispensation before the pandemic onset in 2020. Relative differences (RDs) and their 95% confidence intervals (CIs) were computed to compare the observed and expected counts during the first and second lockdown and the period in between.

Results: During the first 4 weeks of the first lockdown, as compared with the expected numbers, the observed priming dose counts substantially decreased [RD: from −5.7% (95% CI −6.1; −5.2) for penta/hexavalent to −25.2% (95% CI −25.6; −24.8) for MMR], as did the booster counts [RD: from −15.3% (95% CI −15.9; −14.7) for penta/hexavalent to −20.7% (95% CI −21.3; −20.2) for Men-C-C]. Counts for priming doses and boosters remained slightly below the expected numbers after the lockdown. During 2020, MMR priming doses and the Men-C-C booster had the greatest shortfalls (N = 84,893 and 72,500, respectively).

Conclusions: This study provides evidence of a lack of vaccination catch-up after the first lockdown and a persistent shortfall in infant vaccination after the first 10 months of the COVID-19 pandemic in France, especially for the MMR priming doses and Men-C-C booster.
Pediatric Obesity—A Potential Risk Factor for Systemic Inflammatory Syndrome Associated to COVID-19, a Case Report
Authors: Mărginean Cristina Oana , Meliţ Lorena Elena , Săsăran Maria Oana
Published: May 2021

The well-documented systemic inflammation associated to pediatric obesity might act as an augmenting factor for other inflammatory conditions, such as pediatric inflammatory multisystem syndrome (PIMS) associated to COVID-19. We report the case of 9-year-old boy admitted in our clinic for fever, anorexia, and fatigability. The clinical exam revealed influenced general status, palpebral edema, non-exudative conjunctivitis, and abdominal tenderness. The patient weighed 45 kg. The laboratory tests at the time of admission pointed out anemia, lymphopenia; elevated inflammatory biomarkers, NT-proBNP, D-dimers, and troponin; high liver enzymes and lactate dehydrogenase levels, as well as hypoalbuminemia. The patient tested positive for both RT-PCR and serology for SARS-CoV-2 infection. We initiated intravenous immunoglobulin and methylprednisolone, associated with empirical antibiotic, anticoagulation therapy, and symptomatic treatment. The patient was discharged on the 7th day of admission with the recommendation to continue enoxaparin and methylprednisolone at home tapering the dose for the next week. The subclinical inflammatory status associated to obesity might serve as an unfortunate trigger factor for the development of COVID-19 severe forms in children. Therefore, clinicians should be aware that children with obesity and COVID-19 represent a peculiar group that should be closely monitored and thoroughly assessed in order to preempt life-threatening complications, such as PIMS.
Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants
Authors: Li Mingyan , Lv Ying , Ying Jionghuan , Xu Lin , Chen Weijun , Zheng Quan , Ji Chai , Shao Jie
Published: May 2021

Objective: The aim of this study was to investigate the effects of unified iron supplementation and identify the factors related to the iron homeostasis among preterm infants.

Method: A total of 250 preterm infants were divided into neonatal anemic (NA, n = 154) and non-neonatal anemic group (NNA, n = 96). Iron supplements at a dose of 2 mg/kg per day were given from 40 weeks' gestational age to 6 months. Iron status parameters were measured at 3 and 6 months, respectively. Prevalence of iron deficiency (ID) and iron deficiency anemia (IDA), and the correlated factors were analyzed. Growth and side-effects were monitored.

Results: There were no significant differences for the prevalence of ID or IDA between the two groups. Multivariate regression analyses showed that higher Hb at birth and early treatment of blood transfusion reduced the risk of ID/IDA at 3 months (all p < 0.05); while higher level of Hb at 3 months (p = 0.004) and formula feeding reduced the occurrence of ID/IDA at 6 months (p < 0.05); males had a 3.35 times higher risk to develop ID/IDA than girls (p = 0.021). No differences in growth and side effects were found.

Conclusion: A daily dose of 2 mg/kg iron supplement is beneficial to maintain iron homeostasis in majority preterm infants within 6 months regardless of their neonatal anemia history. Under the routine iron supplementation, Hb level at birth and at 3 months, early treatment of blood transfusion, gender and feeding patterns are the major factors affecting the prevalence of ID/IDA among preterm infants in infancy.
Nitric Oxide Is Associated With Heterosis of Salinity Tolerance in Brassica napus L.
Authors: Zhang Yihua , Cheng Pengfei , Wang Jun , Abdalmegeed Dyaaaldin , Li Ying , Wu Mangteng , Dai Chen , Wan Shubei , Guan Rongzhan , Pu Huiming , Shen Wenbiao
Published: May 2021

Heterosis is most frequently manifested as the superior performance of a hybrid than either of the parents, especially under stress conditions. Nitric oxide (NO) is a well-known gaseous signaling molecule that acts as a functional component during plant growth, development, and defense responses. In this study, the Brassica napus L. hybrid (F1, NJ4375 × MB1942) showed significant heterosis under salt stress, during both germination and post-germination periods. These phenotypes in the hybrid were in parallel with the better performance in redox homeostasis, including alleviation of reactive oxygen species accumulation and lipid peroxidation, and ion homeostasis, evaluated as a lower Na/K ratio in the leaves than parental lines. Meanwhile, stimulation of endogenous NO was more pronounced in hybrid plants, compared with parental lines, which might be mediated by nitrate reductase. Proteomic and biochemical analyses further revealed that protein abundance related to several metabolic processes, including chlorophyll biosynthesis, proline metabolism, and tricarboxylic acid cycle metabolism pathway, was greatly suppressed by salt stress in the two parental lines than in the hybrid. The above responses in hybrid plants were intensified by a NO-releasing compound, but abolished by a NO scavenger, both of which were matched with the changes in chlorophyll and proline contents. It was deduced that the above metabolic processes might play important roles in heterosis upon salt stress. Taken together, we proposed that heterosis derived from F1 hybridization in salt stress tolerance might be mediated by NO-dependent activation of defense responses and metabolic processes.
Characterization and Mapping of Spot Blotch in Triticum durum–Aegilops speltoides Introgression Lines Using SNP Markers
Authors: Kaur Jashanpreet , Kaur Jaspal , Dhillon Guriqbal Singh , Kaur Harmandeep , Singh Jasvir , Bala Ritu , Srivastava Puja , Kaur Satinder , Sharma Achla , Chhuneja Parveen
Published: May 2021

Spot blotch (SB) of wheat is emerging as a major threat to successful wheat production in warm and humid areas of the world. SB, also called leaf blight, is caused by Bipolaris sorokiniana, and is responsible for high yield losses in Eastern Gangetic Plains Zone in India. More recently, SB is extending gradually toward cooler, traditional wheat-growing North-Western part of the country which is a major contributor to the national cereal basket. Deployment of resistant cultivars is considered as the most economical and ecologically sound measure to avoid losses due to this disease. In the present study, 89 backcross introgression lines (DSBILs) derived from Triticum durum (cv. PDW274-susceptible) × Aegilops speltoides (resistant) were evaluated against SB for four consecutive years, 2016–2020. Phenotypic evaluation of these lines showed a continuous variation in disease severity indicating that the resistance to SB is certainly quantitative in nature. Phenotypic data of DSBILs were further used for mapping QTLs using SNPs obtained by genotyping by sequencing. To identify QTLs stable across the environments, Best Linear Unbiased Estimates (BLUEs) and Predictions (BLUPs) were used for mapping QTLs based on stepwise regression-based Likelihood Ratio Test (RSTEP-LRT) for additive effect of markers and single marker analysis (SMA). Five QTLs, Q.Sb.pau-2A, Q.Sb.pau-2B, Q.Sb.pau-3B, Q.Sb.pau-5B, and Q.Sb.pau-6A, linked to SB resistance were mapped across chromosomes 2A, 2B, 3B, 5B, and 6A. Genes found adjacent to the SNP markers linked to these QTLs were literature mined to identify possible candidate genes by studying their role in plant pathogenesis. Further, highly resistant DSBIL (DSBIL-13) was selected to cross with a susceptible hexaploidy cultivar (HD3086) generating BC2F1 population. The QTL Q.Sb.pau-5B, linked to SNP S5B_703858864, was validated on this BC2F1 population and thus, may prove to be a potential diagnostic marker for SB resistance.
Mental Health of Chinese People During the COVID-19 Pandemic: Associations With Infection Severity of Region of Residence and Filial Piety
Authors: Li Wendy Wen , Li Yahong , Yu Huizhen , Miller Dan J. , Rouen Christopher , Yang Fang
Published: May 2021

This study aims to investigate mental health among Chinese people living in areas with differing levels of infection severity during the COVID-19 outbreak. It also assesses the association between reciprocal and authoritarian filial piety and mental health in times of crises. A sample of 1,201 Chinese participants was surveyed between April and June 2020. Wuhan city (where 23.4% of participants resided), Hubei province outside Wuhan (13.4% of participants), and elsewhere in China (63.1% of participants) were categorized into high, moderate, and low infection severity areas, respectively. The Depression, Anxiety, and Stress Scale’s severity cut-points were used to categorize participants. In the overall sample, 20.9, 34.2, and 29.0% of the participants showed elevated (mild to extremely severe) levels of stress, anxiety, and depression. Those in the highest infection severity group were significantly more likely to be categorized as having elevated levels of stress, anxiety, and depression. General linear modeling was performed on a composite mental distress variable (taking into account stress, anxiety, and depression scores). This model indicated that, even after adjusting for group differences in age, gender, education, and filial piety, the high infection severity group displayed more mental distress than the low infection severity groups. The model also found reciprocal filial piety to have a negative association with mental distress. Conversely, authoritarian filial piety was found to be unrelated to mental distress when controlling for the other variables in the model. No evidence was found for an interaction between either authoritarian or reciprocal filial piety and infection severity, which suggests that the negative association observed between reciprocal filial piety and mental distress was relatively consistent across the three infection severity groups. The findings suggest that future public health programs may integrate the promotion of filial piety as a strategy to help Chinese people maintain good mental health in the face of pandemic crises.
Third-Party Punishment or Compensation? It Depends on the Reputational Benefits
Authors: Li Zhuang , Hu Gengdan , Xu Lei , Li Qiangqiang
Published: May 2021

Third-party fairness maintenance could win some reputational benefits, and it includes two methods: punishment and compensation. We predicted that the third parties' preference between punishment and compensation are affected by whether they are free to choose between the two methods, and the affection could be interpreted through reputational benefits. The present study includes two sections. In Study 1, the participants acted as fourth parties who were asked to rate the reputations of the third parties who had chosen different response methods to an unfair result of the dictator game. The results showed that (1) there was no reputational difference between the two methods when third parties were not free to choose, (2) but the reputation of compensation was better when third parties were free to choose. In Study 2, the participants acted as third parties. The participants were asked to choose a method to respond to an unfair result of the dictator game. There were two reputational contexts: secret and open. The results showed that (1) when third parties were not free to choose, they had no preference between the two methods under the two reputational contexts, (2) but when third parties were free to choose freely, they prefer punishment under the secret context but prefer compensation under the open context. This study systematically reveals a reputational interaction between fourth and third parties, and verifies the affection of reputational benefits on the third parties' preference between punishment and compensation.
Are Soccer and Futsal Affected by the Relative Age Effect? The Portuguese Football Association Case
Authors: Figueiredo Pedro , Seabra André , Brito Marta , Galvão Marta , Brito João
Published: May 2021

A better understanding of the relative age effect (RAE) in youth will increase the awareness of the need for reducing the bias of (de)selection. Thus, we investigated the RAE in youth female and male soccer and futsal players in Portugal, using nationwide data. Birthdates of 5,306 female and 126,285 male soccer players, and 2,437 female and 23,988 male futsal players (U7–U19), registered in Portugal during the season 2019–2020, and Portuguese National teams (from U15 to AA soccer teams and from U17 to AA futsal teams) were analyzed. Data were categorized into age groups and certification levels [no certification, basic football training center, football school, and training institution] of the respective clubs/academies. Birthdates were stratified from the start of the selection year using quartiles (Q) and semesters (S). Differences between the observed and expected birthdate distributions were analyzed using chi-square statistics, and RAEs were calculated using odds ratios (OR). In both soccer and futsal, female players, in the age category U9, RAEs were found (Q1 vs. Q4, OR: 1.49 and 1.84, respectively). In male soccer, differences in the birthdate distribution were observed in all age categories (U7–U19) with significant OR between all comparisons (Q and S). In contrast, an over-representation of young male futsal players (Q1 vs. Q4) was observed only in the age categories U7 and U9 (OR: 1.54 and 1.34, respectively). The stratification by certification level showed a significant RAE for all certification levels in male soccer players. In contrast, in male futsal players, the RAE was significant only in clubs and academies with the highest level. For National teams, the RAE was more pronounced in male soccer, particularly in the U16 and U17 (OR: 9.84 and 12.36, respectively). Data showed a RAE in female and male youth soccer and futsal, particularly in male, younger age categories, and in clubs and academies having a higher certification level, which could be accompanied by a loss of valuable elite players during the youth phase of their careers. Thus, adjustments in the systems and structure of talent identification are recommended to prevent RAE-related discrimination in youth soccer and futsal.