bluuebunny/crossref_metadata_2025 huggingface dataset:
Renal Function Effect on the Association Between Body Mass Index and Mortality Risk After Acute Myocardial Infarction
Authors: Kang Shin Yeong , Kim Weon , Kim Jin Sug , Jeong Kyung Hwan , Jeong Myung Ho , Hwang Jin Yong , Hwang Hyeon Seok
Published: December 2021

Background: Body mass index (BMI) is a critical determinant of mortality after acute myocardial infarction (AMI), and higher BMI is associated with survival benefit in patients with renal impairment. However, there are no studies investigating the interactive effects of BMI and renal function on mortality risk after AMI occurrence.

Methods: We enrolled 12,647 AMI patients from Korea Acute Myocardial Infarction Registry between November 2011 and December 2015. Patients were categorized based on estimated Glomerular Filtration Rate (eGFR) and BMI. The primary endpoint was all-cause mortality after AMI treatment.

Results: Within each renal function category, the absolute mortality rate was decreased in patients with higher BMI. However, the adjusted hazard ratio (HR) of all-cause mortality for higher BMI was decreased as renal function worsened [adjusted HR (95% confidence interval) at BMI ≥ 25 kg/m2: 0.63 (0.41–0.99), 0.76 (0.59–0.97), and 0.84 (0.65–1.08) for patients with eGFR ≥ 90, 90–45, and <45 mL/min/1.73 m2, respectively]. There was a significant interaction between BMI and renal function (P for interaction = 0.010). The protective effect of higher BMI was preserved against non-cardiac death and it was also decreased with lowering eGFR in competing risks models [adjusted HR at BMI ≥25 kg/m2: 0.38 (0.18–0.83), 0.76 (0.59–0.97), and 0.84 (0.65–1.08) for patients with eGFR ≥ 90, 90–45, and <45 mL/min/1.73 m2, respectively; P for interaction = 0.03]. However, renal function did not significantly affect the association between BMI and risk of cardiac death (P for interaction = 0.20).

Conclusions: The effect of BMI on the mortality risk after AMI was dependent on renal function. The association between greater BMI and survival benefit was weakened as renal function was decreased. In addition, the negative effect of renal function on the BMI – mortality association was pronounced in the non-cardiac death.
Moho Geometry of the Okinawa Trough Based on Gravity Inversion and Its Implications on the Crustal Nature and Tectonic Evolution
Authors: Zhang Liang , Luan Xiwu
Published: December 2021

The Okinawa Trough (OT) is an incipient back-arc basin, but its crustal nature is still controversial. Gravity inversion along with sediment and lithospheric mantle density modeling are used to map the regional Moho depth and crustal thickness variations of the OT and its adjacent areas. The gravity inversion result shows that the crustal thicknesses are 17–22 km at the northern OT, 11–19 km at the central OT, and 7–19 km at the southern OT. Because of the crust with a thickness larger than 17 km, the slow southward arc movement, and scarce contemporaneous volcanisms, the northern OT should be in the stage of early back-arc extension. All of the moderate crustal thickness, high heat flow, and intense volcanism at the central OT indicate that this region is probably in the transitional stage from the back-arc rifting to the oceanic spreading. A crust that is only 7 km thick, lithosphere strength as low as the mid-ocean ridge, and MORB-similar basalts at the southern OT demonstrate that the southern OT is at the early stage of seafloor spreading.
Contributed Reports of Widely Felt Earthquakes in California, United States: If They Felt it, Did They Report it?
Authors: Hough Susan E.
Published: December 2021

In a recent study,Hough and Martin(2021) considered the extent to which socioeconomic factors influence the numbers and distribution of contributed reports available to characterize the effects of both historical and recent large earthquakes. In this study I explore the question further, focusing on analysis of widely felt earthquakes near major population centers in northern and southern California since 2002. For most of these earthquakes there is a correlation between average household income in a postal ZIP code and the population-normalized rate of responses to the DYFI system. As past studies have demonstrated, there is also a strong correlation between DYFI participation and the severity of shaking. This first-order correlation can obscure correlations with other factors that influence participation. Focusing on five earthquakes between 2011 and 2021 that generated especially uniform shaking across the greater Los Angeles, California, region, response rate varies by two orders of magnitude across the region, with a clear correlation with demographics, and consistent spatial patterns in response rate for earthquakes 10 years apart. While there is no evidence that uneven DYFI participation in California impacts significantly the reliability of intensity data collected, the results reveal that DYFI participation is significantly higher in affluent parts of southern California compared to economically disadvantaged areas.
Hormonal Regulation of the MHC Class I Gene in Thyroid Cells: Role of the Promoter “Tissue-Specific” Region
Authors: Giuliani Cesidio , Verrocchio Sara , Verginelli Fabio , Bucci Ines , Grassadonia Antonino , Napolitano Giorgio
Published: December 2021

In previous studies we have demonstrated that the expression of the Major Histocompatibility Complex (MHC) class I gene in thyrocytes is controlled by several hormones, growth factors, and drugs. These substances mainly act on two regions of the MHC class I promoter a “tissue-specific” region (−800 to −676 bp) and a “hormone/cytokines-sensitive” region (−500 to −68 bp). In a previous study, we have shown that the role of the “tissue-specific” region in the MHC class I gene expression is dominant compared to that of the “hormone/cytokines-sensitive” region. In the present report we further investigate the dominant role of the “tissue-specific” region evaluating the effect of thyroid stimulating hormone (TSH), methimazole (MMI), phenylmethimazole (C10), glucose and thymosin-α1. By performing experiments of electrophoretic mobility shift assays (EMSAs) we show that TSH, MMI and C10, which inhibit MHC class I expression, act on the “tissue-specific” region increasing the formation of a silencer complex. Glucose and thymosin-α1, which stimulate MHC class I expression, act decreasing the formation of this complex. We further show that the silencer complex is formed by two distinct members of the transcription factors families activator protein-1 (AP-1) and nuclear factor-kB (NF-kB), c-jun and p65, respectively. These observations are important in order to understand the regulation of MHC class I gene expression in thyroid cells and its involvement in the development of thyroid autoimmunity.
Training Graduate Students in Multiple Genres of Public and Academic Science Writing: An Assessment Using an Adaptable, Interdisciplinary Rubric
Authors: Harrington Erin R. , Lofgren Ingrid E. , Gottschalk Druschke Caroline , Karraker Nancy E. , Reynolds Nedra , McWilliams Scott R.
Published: December 2021

There is an urgent need for scientists to improve their communication skills with the public, especially for those involved in applying science to solve conservation or human health problems. However, little research has assessed the effectiveness of science communication training for applied scientists. We responded to this gap by developing a new, interdisciplinary training model, “SciWrite,” based on three central tenets from scholarship in writing and rhetoric: 1) habitual writing, 2) multiple genres for multiple audiences, and 3) frequent review and created an interdisciplinary rubric based on these tenets to evaluate a variety of writing products across genres. We used this rubric to assess three different genres written by 12 SciWrite-trained graduate science students and 74 non-SciWrite-trained graduate science students at the same institution. We found that written work from SciWrite students scored higher than those from non-SciWrite students in all three genres, and most notably thesis/dissertation proposals were higher quality. The rubric results also suggest that the variation in writing quality was best explained by the ability of graduate students to grasp higher-order writing skills (e.g., thinking about audience needs and expectations, clearly describing research goals, and making an argument for the significance of their research). Future programs would benefit from adopting similar training activities and goals as well as assessment tools that take a rhetorically informed approach.
Impacts of Logging-Associated Compaction on Forest Soils: A Meta-Analysis
Authors: Nazari Meisam , Eteghadipour Mohammad , Zarebanadkouki Mohsen , Ghorbani Mohammad , Dippold Michaela A. , Bilyera Nataliya , Zamanian Kazem
Published: December 2021

Soil compaction associated with mechanized wood harvesting can long-lastingly disturb forest soils, ecosystem function, and productivity. Sustainable forest management requires precise and deep knowledge of logging operation impacts on forest soils, which can be attained by meta-analysis studies covering representative forest datasets. We performed a meta-analysis on the impact of logging-associated compaction on forest soils microbial biomass carbon (MBC), bulk density, total porosity, and saturated hydraulic conductivity (Ksat) affected by two management factors (machine weight and passage frequency), two soil factors (texture and depth), and the time passed since the compaction event. Compaction significantly decreased soil MBC by −29.5% only in subsoils (>30 cm). Overall, compaction increased soil bulk density by 8.9% and reduced total porosity and Ksat by −10.1 and −40.2%, respectively. The most striking finding of this meta-analysis is that the greatest disturbance to soil bulk density, total porosity, and Ksat occurs after very frequent (>20) machine passages. This contradicts the existing claims that most damage to forest soils happens after a few machine passages. Furthermore, the analyzed physical variables did not recover to the normal level within a period of 3–6 years. Thus, altering these physical properties can disturb forest ecosystem function and productivity, because they play important roles in water and air supply as well as in biogeochemical cycling in forest ecosystems. To minimize the impact, we recommend the selection of suitable logging machines and decreasing the frequency of machine passages as well as logging out of rainy seasons especially in clayey soils. It is also very important to minimize total skid trail coverage for sustainable forest management.
Functional and Binding H1N1pdm09-Specific Antibody Responses in Occasionally and Repeatedly Vaccinated Healthcare Workers: A Five-Year Study (2009-2014)
Authors: Amdam Håkon , Madsen Anders , Zhou Fan , Bansal Amit , Trieu Mai-Chi , Cox Rebecca Jane
Published: December 2021

Background

In 2009, a novel influenza A/H1N1pdm09 emerged and caused a pandemic. This strain continued to circulate and was therefore included in the seasonal vaccines up to the 2016/2017-season. This provided a unique opportunity to study the long-term antibody responses to H1N1pdm09 in healthcare workers (HCW) with a different vaccination history.

Methods

HCW at Haukeland University Hospital, Bergen, Norway were immunized with the AS03-adjuvanted H1N1pdm09 vaccine in 2009 (N=55) and divided into groups according to their vaccination history; one vaccination (N=10), two vaccinations (N=15), three vaccinations (N=5), four vaccinations (N=15) and five vaccinations (N=10). HCW are recommended for influenza vaccination to protect both themselves and their patients, but it is voluntary in Norway. Blood samples were collected pre- and at 21 days, 3, 6, and 12 months after each vaccination, or annually from 2010 HCW without vaccination. ELISA, haemagglutination inhibition (HI) and microneutralization (MN) assays were used to determine the antibody response.

Results

Pandemic vaccination induced a significant increase in the H1N1-specific antibodies measured by ELISA, HI and MN. Seasonal vaccination boosted the antibody response, both in HCW with only the current vaccination and those with prior and current vaccination during 2010/11-2013/14. We observed a trend of increased antibody responses in HCW with only the current vaccination in 2013/14. A two- and three-year gap before vaccination in 2013/14 provided a more potent antibody response compared to annually vaccinated HCW.

Conclusions

Our long term follow up study elucidates the antibody response in HCW with different vaccination histories. Our findings contribute to our understanding of the impact of repeated vaccination upon antibody responses.
Risk Factors for Acute Kidney Injury in Adult Patients With COVID-19: A Systematic Review and Meta-Analysis
Authors: Cai Xiaoyue , Wu Guiming , Zhang Jie , Yang Lichuan
Published: December 2021

Background and Objective: Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly around the world. Studies found that the incidence of acute kidney injury (AKI) in COVID-19 patients was more than double the incidence of AKI in non-COVID-19 patients. Some findings confirmed that AKI is a strong independent risk factor for mortality in patients with COVID-19 and is associated with a three-fold increase in the odds of in-hospital mortality. However, little information is available about AKI in COVID-19 patients. This study aimed to analyse the risk factors for AKI in adult patients with COVID-19.

Methods: A systematic literature search was conducted in PubMed, EMBASE, Web of Science, the Cochrane Library, CNKI, VIP and WanFang Data from 1 December 2019 to 30 January 2021. We extracted data from eligible studies to compare the effects of age, sex, chronic diseases and potential risk factors for AKI on the prognosis of adult patients with COVID-19.

Results: In total, 38 studies with 42,779 patients were included in this analysis. The meta-analysis showed that male sex (OR = 1.37), older age (MD = 5.63), smoking (OR = 1.23), obesity (OR = 1.12), hypertension (OR=1.85), diabetes (OR=1.71), pneumopathy (OR = 1.36), cardiovascular disease (OR = 1.98), cancer (OR = 1.26), chronic kidney disease (CKD) (OR = 4.56), mechanical ventilation (OR = 8.61) and the use of vasopressors (OR = 8.33) were significant risk factors for AKI (P < 0.05).

Conclusions: AKI is a common and serious complication of COVID-19. Overall, male sex, age, smoking, obesity, hypertension, diabetes, pneumopathy, cardiovascular disease, cancer, CKD, mechanical ventilation and the use of vasopressors were independent risk factors for AKI in adult patients with COVID-19. Clinicians need to be aware of these risk factors to reduce the incidence of AKI.

System Review Registration: PROSPERO, identifier [CRD42021282233].
CD200R Combined Neutrophil-Lymphocyte Ratio Predict 90-Day Mortality in HBV-Related Acute-On-Chronic Liver Failure
Authors: Li Yuxin , Kong Yaxian , Shi Ke , Huang Yunyi , Zhang Qun , Zhu Bingbing , Zeng Hui , Wang Xianbo
Published: December 2021

Background:Survival of acute-on-chronic liver failure (ACLF) cannot be properly predicted based on clinical characteristics.

Aims:This study aimed to develop a predictive model to evaluating the prognosis for hepatitis B virus-related ACLF (HBV-ACLF) based on specific laboratory and immune indicators.

Methods:Baseline laboratory results were obtained and immune indicators were detected by flow cytometry. A predictive model, which estimates the prognosis at 90-day follow-up, was developed using data from a prospective study on 45 patients hospitalized of HBV-ACLF from June 2016 to April 2018 at the Beijing Ditan Hospital, Capital Medical University. The prognostic values of the predictive factors were determined by the area under the receiver operating characteristic (AUROC) curves.

Results:Six factors exhibited statistical differences between the survival and non-survival groups: proportions of CD4+TN, CD4+TEM, CD8+TN, CD8+TEM, CD200R+CD4+T cells and neutrophil-lymphocyte ratio (NLR). CD200R combined with the NLR had an AUROC of 0.916, which was significantly higher than the AUROC values of CD200R+CD4+T cells (0.868), NLR (0.761), model for end-stage liver disease (MELD) (0.840), MELD-Na (0.870), Child-Turcotte-Pugh (CTP) (0.580), or chronic liver failure-consortium ACLF (CLIF-C ACLF) score(0.840). At the cut-off point of−3.87, matching the maximum Youden index determined by ROC analysis, the positive predictive and negative predictive values for the mortality were 0.86 and 0.97, respectively.

Conclusions:The 90-day prediction model based on baseline levels of CD200R+CD4+T cells and NLR offers potential predictive value for the mortality of HBV-ACLF.
Early Enteral Nutrition Tolerance in Patients With Cardiogenic Shock Requiring Mechanical Circulatory Support
Authors: Liu Wen-jun , Zhong Jun , Luo Jing-chao , Zheng Ji-li , Ma Jie-fei , Ju Min-jie , Su Ying , Liu Kai , Tu Guo-wei , Luo Zhe
Published: December 2021

Background: Enteral nutrition (EN) is recommended within the first 24–48 h for patients with hemodynamic stability, following admission to an intensive care unit (ICU). However, for patients with approximate stable hemodynamics requiring mechanical circulatory support and vasoactive drugs, the application of early EN remains controversial. We sought to evaluate the tolerance of early EN in patients with cardiogenic shock who required vasoactive drugs and mechanical circulatory support after cardiac surgery.

Methods: This single-center, prospective observational study included patients with cardiogenic shock, requiring vasoactive drugs and mechanical circulatory support after cardiac surgery, undergoing EN. The primary endpoint was EN tolerance and secondary endpoints were mortality, length of mechanical ventilation, and length of ICU stay.

Results: From February 2019 to December 2020, 59 patients were enrolled, of which 25 (42.37%) developed intolerance within 3 days of starting EN. Patients in the EN intolerant group had a longer median length of mechanical ventilation (380 vs. 128 h, p = 0.006), a longer median ICU stay (20 vs. 11.5 days, p = 0.03), and a higher proportion of bloodstream infections (44 vs. 14.71%, p = 0.018). The median EN calorie levels for all patients in the first 3 days of EN were 4.00, 4.13, and 4.28 kcal/kg/day, respectively. Median protein intake levels of EN in the first 3 days were 0.18, 0.17, and 0.17 g/kg/day, respectively. No significant difference was observed in the median dose of vasoactive drugs between the groups (0.035 vs. 0.05 μg/kg/min, p = 0.306).

Conclusions: Patients with cardiogenic shock after cardiac surgery had a high proportion of early EN intolerance, and patients with EN intolerance had a worse prognosis, but no significant correlation was identified between EN tolerance and the dose of vasoactive drugs.
Multi-Target Coordinated Search Algorithm for Swarm Robotics Considering Practical Constraints
Authors: Zhou You , Chen Anhua , He Xinjie , Bian Xiaohui
Published: December 2021

In order to deal with the multi-target search problems for swarm robots in unknown complex environments, a multi-target coordinated search algorithm for swarm robots considering practical constraints is proposed in this paper. Firstly, according to the target detection situation of swarm robots, an ideal search algorithm framework combining the strategy of roaming search and coordinated search is established. Secondly, based on the framework of the multi-target search algorithm, a simplified virtual force model is combined, which effectively overcomes the real-time obstacle avoidance problem in the target search of swarm robots. Finally, in order to solve the distributed communication problem in the multi-target search of swarm robots, a distributed neighborhood communication mechanism based on a time-varying characteristic swarm with a restricted random line of sight is proposed, and which is combined with the multi-target search framework. For the swarm robot kinematics, obstacle avoidance, and communication constraints of swarm robots, the proposed multi-target search strategy is more stable, efficient, and practical than the previous methods. The effectiveness of this proposed method is verified by numerical simulations.
The Nutritional Profiles of Five Important Edible Insect Species From West Africa—An Analytical and Literature Synthesis
Authors: Anankware Jacob P. , Roberts Benjamin J. , Cheseto Xavier , Osuga Isaac , Savolainen Vincent , Collins C. M.
Published: December 2021

Background: Undernutrition is a prevalent, serious, and growing concern, particularly in developing countries. Entomophagy—the human consumption of edible insects, is a historical and culturally established practice in many regions. Increasing consumption of nutritious insect meal is a possible combative strategy and can promote sustainable food security. However, the nutritional literature frequently lacks consensus, with interspecific differences in the nutrient content of edible insects generally being poorly resolved.

Aims and methods: Here we present full proximate and fatty acid profiles for five edible insect species of socio-economic importance in West Africa: Hermetia illucens (black soldier fly), Musca domestica (house fly), Rhynchophorus phoenicis (African palm weevil), Cirina butyrospermi (shea tree caterpillar), and Macrotermes bellicosus (African termite). These original profiles, which can be used in future research, are combined with literature-derived proximate, fatty acid, and amino acid profiles to analyse interspecific differences in nutrient content.

Results: Interspecific differences in ash (minerals), crude protein, and crude fat contents were substantial. Highest ash content was found in H. illucens and M. domestica (~10 and 7.5% of dry matter, respectively), highest crude protein was found in C. butyrospermi and M. domestica (~60% of dry matter), whilst highest crude fat was found in R. phoenicis (~55% of dry matter). The fatty acid profile of H. illucens was differentiated from the other four species, forming its own cluster in a principal component analysis characterized by high saturated fatty acid content. Cirina butyrospermi had by far the highest poly-unsaturated fatty acid content at around 35% of its total fatty acids, with α-linolenic acid particularly represented. Amino acid analyses revealed that all five species sufficiently met human essential amino acid requirements, although C. butyrospermi was slightly limited in leucine and methionine content.

Discussion: The nutritional profiles of these five edible insect species compare favorably to beef and can meet human requirements, promoting entomophagy's utility in combatting undernutrition. In particular, C. butyrospermi may provide a source of essential poly-unsaturated fatty acids, bringing many health benefits. This, along with its high protein content, indicates that this species is worthy of more attention in the nutritional literature, which has thus-far been lacking.
Case Report: Reconstruction of a Large Maxillary Defect With an Engineered, Vascularized, Prefabricated Bone Graft
Authors: Ismail Tarek , Haumer Alexander , Lunger Alexander , Osinga Rik , Kaempfen Alexandre , Saxer Franziska , Wixmerten Anke , Miot Sylvie , Thieringer Florian , Beinemann Joerg , Kunz Christoph , Jaquiéry Claude , Weikert Thomas , Kaul Felix , Scherberich Arnaud , Schaefer Dirk J. , Martin Ivan
Published: December 2021

The reconstruction of complex midface defects is a challenging clinical scenario considering the high anatomical, functional, and aesthetic requirements. In this study, we proposed a surgical treatment to achieve improved oral rehabilitation and anatomical and functional reconstruction of a complex defect of the maxilla with a vascularized, engineered composite graft. The patient was a 39-year-old female, postoperative after left hemimaxillectomy for ameloblastic carcinoma in 2010 and tumor-free at the 5-year oncological follow-up. The left hemimaxillary defect was restored in a two-step approach. First, a composite graft was ectopically engineered using autologous stromal vascular fraction (SVF) cells seeded on an allogenic devitalized bone matrix. The resulting construct was further loaded with bone morphogenic protein-2 (BMP-2), wrapped within the latissimus dorsi muscle, and pedicled with an arteriovenous (AV) bundle. Subsequently, the prefabricated graft was orthotopically transferred into the defect site and revascularized through microvascular surgical techniques. The prefabricated graft contained vascularized bone tissue embedded within muscular tissue. Despite unexpected resorption, its orthotopic transfer enabled restoration of the orbital floor, separation of the oral and nasal cavities, and midface symmetry and allowed the patient to return to normal diet as well as to restore normal speech and swallowing function. These results remained stable for the entire follow-up period of 2 years. This clinical case demonstrates the safety and the feasibility of composite graft engineering for the treatment of complex maxillary defects. As compared to the current gold standard of autologous tissue transfer, this patient’s benefits included decreased donor site morbidity and improved oral rehabilitation. Bone resorption of the construct at the ectopic prefabrication site still needs to be further addressed to preserve the designed graft size and shape.
Efficacy and Safety of Concurrent Chemoradiotherapy Combined With Induction Chemotherapy or Adjuvant Chemotherapy in Patients With Stage II–IVA Nasopharyngeal Carcinoma: A Propensity Score Matching Analysis and Meta-Analysis
Authors: Yang Jie , Liang Zhong-Guo , Jiang Yu-Ting , Chen Kai-Hua , Li Ling , Qu Song , Zhu Xiao-Dong
Published: December 2021

Purpose

To evaluate the efficacy and safety of induction chemotherapy (IC) combined with concurrent chemoradiotherapy (CCRT) versus CCRT combined with adjuvant chemotherapy (AC) in patients with stage II–IVA nasopharyngeal carcinoma (NPC), we conducted a retrospective study and a meta-analysis combining the results of our studies.

Patients and Methods

We used the propensity score matching (PSM) to balance variables. A total of 168 patients were chosen by one-to-two PSM, including 101 patients with IC + CCRT and 67 cases with CCRT + AC. We used the Kaplan–Meier curve to compare survival outcomes and also used Cox regression analysis to determine independent prognostic factors. For meta-analysis, we determined the related studies by searching the PubMed database. We used STATA v12 software to perform meta-analysis of the extracted data and calculate pooled hazard ratios, 95% confidence intervals of survival outcomes, and risk ratios for the toxicities.

Results

In this retrospective study, there was no significant difference in 5-year overall survival (76.9% vs. 79.0%, P = 0.966), progression-free survival (71.3% vs. 68.5%, P = 0.332), distant metastasis-free survival (80.5% vs. 74.2%, P = 0.140), and locoregional relapse-free survival (91.5% vs. 91.8%, P = 0.894) among patients with NPC with IC + CCRT versus CCRT + AC after PSM. For meta-analysis, six articles (including our study) reporting 1,052 cases of IC + CCRT and 883 cases of CCRT + AC were included in the meta-analysis. There was no difference of OS (pooled HR = 0.90, 95% CI: 0.63–1.29, P = 0.561), PFS (pooled HR = 1.07, 95% CI: 0.87–1.33, P = 0.633), DMFS (pooled HR= 0.98, 95% CI: 0.76-1.25, P=0.861), and LRRFS (pooled HR = 1.06, 95% CI: 0.76–1.48, P = 0.724).

Conclusion

The efficacy of IC + CCRT and CCRT + AC was comparable in patients with stage II–IVA NPC. In terms of compliance and acute adverse reactions, IC + CCRT may be a potential therapeutic strategy.
Early Dynamics and Depth of Response in Multiple Myeloma Patients Treated With BCMA CAR-T Cells
Authors: Wong Sandy W. , Shah Nina , Ledergor Guy , Martin Thomas , Wolf Jeffrey , Shui Amy M. , Huang Chiung-Yu , Martinez-Lopez Joaquin
Published: December 2021

Chimeric antigen receptor T-cell (CAR-T) therapy targeted against B-cell maturation antigen (BCMA) in multiple myeloma (MM) has produced rapid responses but many eventually relapse. In light of this new treatment, novel predictors of progression-free survival (PFS) are needed. We performed a single institution analysis of 54 BCMA-CAR-T patients. We analyzed patient’s overall response rate (ORR) by the IMWG criteria, involved serum-free light chains (iFLC), and minimal residual disease testing by next-generation sequencing (MRD-NGS). Between patients who achieved a ≤SD and those who achieved a ≥PR, PFS differed significantly (p < 0.0001); though there was no difference between patients who achieved a ≥CR vs. VGPR/PR (p = 0.2). In contrast, patients who achieved a nonelevated iFLC at 15 days (p < 0.0001, HR = 6.8; 95% CI, 2.7–17.3) or 30 days (p < 0.001, HR = 16.7; 95% CI, 3.9–71.7) had a prolonged PFS compared with those with an elevated iFLC. Patients achieving MRD-NGS less than the detectable limit at a sensitivity of 10−6 had a better PFS than those with detectable disease at 1 month (p = 0.02) and 3 months (p = 0.02). In conclusion, achieving a nonelevated iFLC and an undetectable MRD-NGS quickly were factors that were strongly associated with improved PFS. Further studies are needed to confirm the role of these markers in MM patients receiving CAR-T therapies.
Congenital Pulmonary Airway Malformation in Children: Advantages of an Additional Trocar in the Lower Thorax for Pulmonary Lobectomy
Authors: Koga Hiroyuki , Ochi Takanori , Hirayama Shunki , Watanabe Yukio , Ueno Hiroyasu , Imashimizu Kota , Suzuki Kazuhiro , Kuwatsuru Ryohei , Nishimura Kinya , Lane Geoffrey J. , Suzuki Kenji , Yamataka Atsuyuki
Published: December 2021

Aim: To present the use of an additional trocar (AT) in the lower thorax during thoracoscopic pulmonary lobectomy (TPL) in children with congenital pulmonary airway malformation.

Methods: For a lower lobe TPL (LL), an AT is inserted in the 10th intercostal space (IS) in the posterior axillary line after trocars for a 5-mm 30° scope, and the surgeon's left and right hands are inserted conventionally in the 6th, 4th, and 8th IS in the anterior axillary line, respectively. For an upper lobe TPL (UL), the AT is inserted in the 9th IS, and trocars are inserted in the 5th, 3rd, and 7th IS, respectively. By switching between trocars (6th↔8th for the scope, 4th↔6th for the left hand, and 8th↔10th for the right hand during LL and 5th↔7th, 3rd↔5th, and 7th↔9th during UL, respectively), vital anatomic landmarks (pulmonary veins, bronchi, and feeding arteries) can be viewed posteriorly. The value of AT was assessed from blood loss, operative time, duration of chest tube insertion, requirement for post-operative analgesia, and incidence of perioperative complications.

Results: On comparing AT+ (n = 28) and AT– (n = 27), mean intraoperative blood loss (5.6 vs. 13.0 ml), operative time (3.9 vs. 5.1 h), and duration of chest tube insertion (2.2 vs. 3.4 days) were significantly decreased with AT (p < 0.05, respectively). Differences in post-operative analgesia were not significant. There were three complications requiring conversion to open/mini-thoracotomy: AT– (n = 2; bleeding), AT+: (n = 1; erroneous stapling).

Conclusions: An AT and switching facilitated posterior dissection during TPL in children with congenital pulmonary airway malformation enhancing safety and efficiency.
Case Report: Treatment of Extremely Preterm Infants With Birthweight Below 300 g: Case Series
Authors: Shitara Yoshihiko , Kakiuchi Satsuki , Mukai Takeo , Kashima Kohei , Kato Motohiro , Takahashi Naoto
Published: December 2021

Reports on the birth of infants weighing <300 g are quite rare and little is known about the best practices in treating such micropreemies. Therefore, we report here on three cases of low birthweight infants weighing <300 g, of whom two infants survived. The birthweights and gestational ages were ranging 279–293 g and 22 + 6/7 – 23 + 6/7 weeks, respectively. All the infants had severe fetal growth restriction and prematurity. The infant in case 1 died of hepatic rupture, perhaps due to birth trauma, which emphasized the need for less invasive obstetric procedures including en caul delivery. The infant in case 2 managed to survive through severe prematurity secondary to hydrops fetalis. However, complications followed soon as tracheal granulation tissue was formed with neurodevelopmental impairment. The infant in case 3 was born recently and her clinical course was less remarkable without severe complications, despite having the least gestational age and birthweight among the three patients. The improved care protocols for extremely low birthweight infants over these years through experiential learning including that with cases 1 and 2 may have ensured the better outcome of case 3. Accumulating evidence and recording the experience of such cases with continuous constructive discussion can contribute to better outcomes and appropriate parental counseling for extremely small babies in the future.
Extreme Hypoxia Causing Brady-Arrythmias During Apnea in Elite Breath-Hold Divers
Authors: Kjeld Thomas , Isbrand Anders Brenøe , Linnet Katrine , Zerahn Bo , Højberg Jens , Hansen Egon Godthaab , Gormsen Lars Christian , Bejder Jacob , Krag Thomas , Vissing John , Bøtker Hans Erik , Arendrup Henrik Christian
Published: December 2021

Introduction: The cardiac electrical conduction system is very sensitive to hypoglycemia and hypoxia, and the consequence may be brady-arrythmias. Weddell seals endure brady-arrythmias during their dives when desaturating to 3.2 kPa and elite breath-hold-divers (BHD), who share metabolic and cardiovascular adaptions including bradycardia with diving mammals, endure similar desaturation during maximum apnea. We hypothesized that hypoxia causes brady-arrythmias during maximum apnea in elite BHD. Hence, this study aimed to define the arterial blood glucose (Glu), peripheral saturation (SAT), heart rhythm (HR), and mean arterial blood pressure (MAP) of elite BHD during maximum apneas.

Methods: HR was monitored with Direct-Current-Pads/ECG-lead-II and MAP and Glu from a radial arterial-catheter in nine BHD performing an immersed and head-down maximal static pool apnea after three warm-up apneas. SAT was monitored with a sensor on the neck of the subjects. On a separate day, a 12-lead-ECG-monitored maximum static apnea was repeated dry (n = 6).

Results: During pool apnea of maximum duration (385 ± 70 s), SAT decreased from 99.6 ± 0.5 to 58.5 ± 5.5% (∼PaO2 4.8 ± 1.5 kPa, P < 0.001), while Glu increased from 5.8 ± 0.2 to 6.2 ± 0.2 mmol/l (P = 0.009). MAP increased from 103 ± 4 to 155 ± 6 mm Hg (P < 0.005). HR decreased to 46 ± 10 from 86 ± 14 beats/minute (P < 0.001). HR and MAP were unchanged after 3–4 min of apnea. During dry apnea (378 ± 31 s), HR decreased from 55 ± 4 to 40 ± 3 beats/minute (P = 0.031). Atrioventricular dissociation and junctional rhythm were observed both during pool and dry apneas.

Conclusion: Our findings contrast with previous studies concluding that Glu decreases during apnea diving. We conclude during maximum apnea in elite BHD that (1) the diving reflex is maximized after 3–4 min, (2) increasing Glu may indicate lactate metabolism in accordance with our previous results, and (3) extreme hypoxia rather than hypoglycemia causes brady-arrythmias in elite BHD similar to diving mammals.
Evidence for the Application of Emerging Technologies to Accelerate Crop Improvement – A Collaborative Pipeline to Introgress Herbicide Tolerance Into Chickpea
Authors: Croser Janine , Mao Dili , Dron Nicole , Michelmore Simon , McMurray Larn , Preston Christopher , Bruce Dylan , Ogbonnaya Francis Chuks , Ribalta Federico Martin , Hayes Julie , Lichtenzveig Judith , Erskine William , Cullis Brian , Sutton Tim , Hobson Kristy
Published: December 2021

Accelerating genetic gain in crop improvement is required to ensure improved yield and yield stability under increasingly challenging climatic conditions. This case study demonstrates the effective confluence of innovative breeding technologies within a collaborative breeding framework to develop and rapidly introgress imidazolinone Group 2 herbicide tolerance into an adapted Australian chickpea genetic background. A well-adapted, high-yielding desi cultivar PBA HatTrick was treated with ethyl methanesulfonate to generate mutations in the ACETOHYDROXYACID SYNTHASE 1 (CaAHAS1) gene. After 2 years of field screening with imidazolinone herbicide across >20 ha and controlled environment progeny screening, two selections were identified which exhibited putative herbicide tolerance. Both selections contained the same single amino acid substitution, from alanine to valine at position 205 (A205V) in the AHAS1 protein, and KASP™ markers were developed to discriminate between tolerant and intolerant genotypes. A pipeline combining conventional crossing and F2 production with accelerated single seed descent from F2:4 and marker-assisted selection at F2 rapidly introgressed the herbicide tolerance trait from one of the mutant selections, D15PAHI002, into PBA Seamer, a desi cultivar adapted to Australian cropping areas. Field evaluation of the derivatives of the D15PAHI002 × PBA Seamer cross was analyzed using a factor analytic mixed model statistical approach designed to accommodate low seed numbers resulting from accelerated single seed descent. To further accelerate trait introgression, field evaluation trials were undertaken concurrent with crop safety testing trials. In 2020, 4 years after the initial cross, an advanced line selection CBA2061, bearing acetohydroxyacid synthase (AHAS) inhibitor tolerance and agronomic and disease resistance traits comparable to parent PBA Seamer, was entered into Australian National Variety Trials as a precursor to cultivar registration. The combination of cross-institutional collaboration and the application of novel pre-breeding platforms and statistical technologies facilitated a 3-year saving compared to a traditional breeding approach. This breeding pipeline can be used as a model to accelerate genetic gain in other self-pollinating species, particularly food legumes.
Investigating the Interaction Between Prosody and Pragmatics Quantitatively: A Case Study of the Chinese Discourse Marker ni zhidao (“You Know”)
Authors: Shan Yi
Published: December 2021

This study briefly describes the prosodic and pragmatic characteristics of the discourse markerni zhidao(“you know”) in spoken Chinese. It mainly explores the interaction between its prosody and pragmatics using instrumental methods. It is the first attempt to use acoustic and statistical analysis to examine the prosodic parameters and prosody-pragmatics interaction of a Chinese discourse marker. The corpus includes 71 interview conversations totaling more than 30 h, in which 490 discourse marker tokens ofni zhidaowere found.Ni zhidaomainly fulfilled four broad pragmatic functions of initiating a topic when occurring sentence-initially, of holding the floor when appearing within clauses, of marking coherence when making its presence between clauses, and of projecting attitudes and feelings when showing up sentence-finally. Drawing on the algorithm of random forest in R, the acoustic and statistical analysis of the performance ofni zhidaoin these four functions showed that its prosodic features, including duration, tempo, pre-pause, post-pause, F0, and intensity, significantly relate to and thus imply its pragmatic functions, that the interaction between its prosody and pragmatics can be modeled statistically, and that the established pragmatics classification model based on prosody can be utilized to predict the pragmatics ofni zhidao. These findings seem to strengthen the hypothesis that prosodic variables play a role in deciphering the different pragmatic functions ofni zhidao. This study uses prosodic evidence to more objectively reveal not only the part ofni zhidaoin dynamically constructing and embodying specific contexts but also its communicative functions and the underlying meta-pragmatic awareness behind it. This study breaks through the limitations of traditional discourse marker research, which mainly relies on context and discourse characteristics for subjective reasoning.
Philanthropic Motives of China’s Celebrities in Media Representation: From an Impression Management Perspective
Authors: Gao Jinghua , Zhang Pengfei
Published: December 2021

Background: In China, celebrities, represented by entertainment and sports personalities, are often involved in charitable activities to assist the party-state in solving social problems. Although previous research has addressed the manifestation of prosocial behavior by Chinese celebrities, altruistic engagements have rarely been theorized from the perspective of impression management.

Methods: Based on the perspective of impression management, we use the discourse analysis approach to analyze the interview manuscripts of Chinese celebrities in media reports and then summarize the charitable motives and impression management strategies adopted by Chinese celebrities in their self-presentation.

Results: Chinese celebrities’ self-presentation of philanthropic motives in the media can be roughly divided into five categories: motivation for empathy-altruism, motivation for social responsibility, motivation to gain prestige, and pursue fame, motivation to reduce negative emotions, and motivation to achieve fulfillment and satisfaction. The philanthropic motives presented in media reports include the impression management processes of celebrities. They adopt a variety of image management strategies to self-present their philanthropic motives, and sometimes several strategies coexist.

Conclusion: Our paper helps to expand the existing understanding of the relationship between impression management and philanthropy. The presentation of Chinese celebrities’ philanthropic motivations in the media reflects the uniqueness of China’s political, institutional, and social environment in influencing celebrity philanthropy. As a philanthropic phenomenon with Chinese characteristics, this study could provide some insights into the understanding of celebrities and philanthropy in other cultural contexts.
My Health Too: Investigating the Feasibility and the Acceptability of an Internet-Based Cognitive-Behavioral Therapy Program Developed for Healthcare Workers
Authors: Bureau Raven , Bemmouna Doha , Faria Clara Gitahy Falcao , Goethals Anne-Aline Catteau , Douhet Floriane , Mengin Amaury C. , Fritsch Aurélie , Zinetti Bertschy Anna , Frey Isabelle , Weiner Luisa
Published: December 2021

Background: The COVID-19 crisis has had a considerable mental health impact on healthcare workers. High levels of psychological distress are expected to have a significant impact on healthcare systems, warranting the need for evidence-based psychological interventions targeting stress and fostering resilience in this population. Online cognitive behavioral therapy (CBT) has proved to be effective in targeting stress and promoting resilience. However, online CBT programs targeting stress in healthcare workers are lacking.

Objective: The aim of our study is to evaluate the feasibility and acceptability of an internet-based CBT intervention, the My Health Too program we developed during the first COVID-19 epidemic peak in France.

Methods: We recruited 10 participants among Alsace region hospital staff during the first peak of the pandemic in France. They were given 1 week to test the website and were then asked to answer an internet survey and a semi-structured phone interview.

Results: We conducted a thematic analysis of the content from the phone interviews. Major themes were identified, discussed and coded: the technical aspects, the content of the website and its impact on participants’ emotions and everyday life. Overall, the participants reported finding the website easy to use and interactive. They described the resources as easy to understand, readily usable, and useful in inducing calm and in helping them practice self-compassion.

Conclusion: Our results suggest that the My Health Too online CBT program is highly feasible and acceptable to healthcare workers during the highly stressful times of the pandemic peak. The feedback provided helped to improve the program whose efficacy is to be tested.
Academic Well-Being in Higher Education: A Cross-Country Analysis of the Relationship Between Perceptions of Instruction and Academic Well-Being
Authors: Donohue Dana K. , Bornman Juan
Published: December 2021

The purpose of this research was to explore the relationship between university students’ perceptions of the overall quality of instruction (PQI) they experienced since COVID-19 and their academic well-being. This relationship was examined in the context of a moderated moderation with students’ household income and the cultural value of power distance (PD), which measures the extent to which less powerful members of an organization expect and accept that power is unequally distributed. Two countries with societally moderate levels of PD (South Africa and the United States) were assessed. Moderated moderations between PQI, income, and PD were found for the academic well-being of students from both the United States and South Africa. The patterns of interactions were in some ways similar and other ways different, highlighting the complexity of how students may react to potential stressors in their academic environment. Potential explanations and implications of these results are discussed.
Self-Consistency Congruence and Smartphone Addiction in Adolescents: The Mediating Role of Subjective Well-Being and the Moderating Role of Gender
Authors: Li Yang , Ma Xiaoqing , Li Chun , Gu Chuanhua
Published: December 2021

Adolescent smartphone addiction has increasingly attracted the attention of scholars because of the widespread use of internet technology in educational environments. In addition, previous studies have found that there is a complex relationship between smartphone addiction and self-consistency congruence, and subjective well-being. This research was conducted to examine whether subjective well-being would mediate the relation between self-consistency congruence and adolescent smartphone addiction, and whether gender would moderate the mediating process. A total of 1,011 Chinese adolescents completed self-report questionnaires measuring self-consistency congruence, subjective well-being, and smartphone addiction. Self-consistency congruence was shown to be a significant predictor of smartphone addiction. Furthermore, subjective well-being partially mediated the association between self-consistency congruence and adolescent smartphone addiction. Gender could moderate the mediating process; as compared with boys, girls’ self-consistency congruence and subjective well-being are more easily mediated. We envision the findings as being helpful in guiding scholars who are developing interventions to minimize smartphone addiction and its disrupting effects in adolescents.
Pragmatic Competence and Willingness to Communicate Among L2 Learners of Chinese
Authors: Lv Xiaoxuan , Ren Wei , Li Lin
Published: December 2021

Research in second language (L2) pragmatics has paid increasing attention to learners’ individual differences, but few studies have examined the relationship between learners’ willingness to communicate (WTC) in L2 and their pragmatic competence. To this end, this study investigates the association between WTC and pragmatic awareness and comprehension of Chinese as a second language (CSL) learners. A total of 80 CSL learners studying abroad in three universities in China participated in this study. Data were collected through a WTC questionnaire, a self-perceived communication competence (SPCC) questionnaire, a pragmatic awareness judgment task, and a multiple-choice test for pragmatic comprehension. Statistical analyses were conducted to explore the relationship between the learners’ pragmatic awareness and pragmatic comprehension on the one hand and their WTC and SPCC in L2 on the other. The findings indicated that SPCC correlated positively with the learners’ L2 pragmatic comprehension, but not with their L2 pragmatic awareness. No correlation was found between WTC and pragmatic awareness and comprehension. The results suggest that SPCC may contribute to learners’ L2 pragmatic comprehension; some implications for teaching and future research directions are also discussed.