bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure SF1 from Targeting the Epidermal Growth Factor Receptor Pathway in Chemotherapy-Resistant Triple-Negative Breast Cancer: A Phase II Study
Authors: Yam Clinton , Patel Miral , Hill Holly A. , Sun Ryan , Bassett Roland L. , Kong Elisabeth , Damodaran Senthil , Koenig Kimberly B. , Abouharb Sausan , Saleem Sadia , Bisen Ajit K. , Murthy Rashmi K. , Ramirez David L. , Rauch Gaiane M. , Adrada Beatriz E. , Candelaria Rosalind P. , Wang Xiaoping , Mittendorf Elizabeth A. , Thompson Alastair M. , White Jason B. , Ravenberg Elizabeth E. , Clayborn Alyson R. , Ding Qing-Qing , Booser Daniel J. , Oke Oluchi , Brewster Abenaa M. , Hortobagyi Gabriel N. , Ibrahim Nuhad K. , Litton Jennifer K. , Valero Vicente , Arun Banu K. , Tripathy Debu , Chang Jeffrey T. , Chen Ken , Korkut Anil , Moulder Stacy L. , Huo Lei , Lim Bora , Ueno Naoto T.
Published: October 2024

Somatic mutations identified by whole exome sequencing. Oncoplot representing the most common somatic mutations assessed by whole exome sequencing (WES) in tumors obtained from patients (n = 23) at the time of diagnosis. Genes with mutations occurring in five or more patients are shown.
SUPPLEMENTARY TABLE ST2 from Targeting the Epidermal Growth Factor Receptor Pathway in Chemotherapy-Resistant Triple-Negative Breast Cancer: A Phase II Study
Authors: Yam Clinton , Patel Miral , Hill Holly A. , Sun Ryan , Bassett Roland L. , Kong Elisabeth , Damodaran Senthil , Koenig Kimberly B. , Abouharb Sausan , Saleem Sadia , Bisen Ajit K. , Murthy Rashmi K. , Ramirez David L. , Rauch Gaiane M. , Adrada Beatriz E. , Candelaria Rosalind P. , Wang Xiaoping , Mittendorf Elizabeth A. , Thompson Alastair M. , White Jason B. , Ravenberg Elizabeth E. , Clayborn Alyson R. , Ding Qing-Qing , Booser Daniel J. , Oke Oluchi , Brewster Abenaa M. , Hortobagyi Gabriel N. , Ibrahim Nuhad K. , Litton Jennifer K. , Valero Vicente , Arun Banu K. , Tripathy Debu , Chang Jeffrey T. , Chen Ken , Korkut Anil , Moulder Stacy L. , Huo Lei , Lim Bora , Ueno Naoto T.
Published: October 2024

Type of Surgery and Adjuvant Therapy Received.
Figure 3 from Targeting the Epidermal Growth Factor Receptor Pathway in Chemotherapy-Resistant Triple-Negative Breast Cancer: A Phase II Study
Authors: Yam Clinton , Patel Miral , Hill Holly A. , Sun Ryan , Bassett Roland L. , Kong Elisabeth , Damodaran Senthil , Koenig Kimberly B. , Abouharb Sausan , Saleem Sadia , Bisen Ajit K. , Murthy Rashmi K. , Ramirez David L. , Rauch Gaiane M. , Adrada Beatriz E. , Candelaria Rosalind P. , Wang Xiaoping , Mittendorf Elizabeth A. , Thompson Alastair M. , White Jason B. , Ravenberg Elizabeth E. , Clayborn Alyson R. , Ding Qing-Qing , Booser Daniel J. , Oke Oluchi , Brewster Abenaa M. , Hortobagyi Gabriel N. , Ibrahim Nuhad K. , Litton Jennifer K. , Valero Vicente , Arun Banu K. , Tripathy Debu , Chang Jeffrey T. , Chen Ken , Korkut Anil , Moulder Stacy L. , Huo Lei , Lim Bora , Ueno Naoto T.
Published: October 2024

Survival outcomes. A, Kaplan–Meier plot of EFS for all patients. B, Kaplan–Meier plot of EFS separated by pathological response. C, Kaplan–Meier plot of MFS for all patients. D, Kaplan–Meier plot of MFS separated by pathological response. E, Kaplan–Meier plot of OS for all patients. F, Kaplan–Meier plot of OS separated by pathological response.
Notes on the extended distribution of Ceropegia gardneri Thwaites and other rare species of Ceropegia from southern Western Ghats, India
Authors: E.J. Josekutty  , P. Biju  , Jomy Augustine
Published: October 2024

The extended distributional record of a threatened species of Ceropegia namely Ceropegia gardneri from Kerala is provided. This species exhibits a narrow range of distribution along the Western Ghats and in Sri Lanka. Details of four other rare species of Ceropegia are also given. Notes on taxonomy, phenology, distribution and conservation status are also provided for the better understanding of the species.
Importance based on avian diversity of Pakhibitan Bird & Wildlife Sanctuary, Jalpaiguri District, West Bengal, India
Authors: Basu Roy Arjan , Samanta Tarak , C.S. Samrat  , Guha Anjan , Datta Debarpan , Rong Abhik , Chatterjee Lina
Published: October 2024

A comprehensive inventory of faunal and floral species in a specific region holds significant value for scientific investigation. This study was conducted between 2015 and 2021, especially during the winter season, in Pakhibitan Bird & Wildlife Sanctuary (also known as Gajoldoba wetland) in West Bengal, which was established in 2016. This wetland surrounded by forests is located on the upper section of the Teesta Barrage in the Dooars region of Jalpaiguri District, and it attracts birds from the Central Asian Flyway. Around 124 bird species belonging to 14 orders and 37 families were documented. Passeriformes with 32 species, and Anatidae with 23 species, are the most abundant groups. Based on the IUCN Red Data Book (2022–23), six species are Near Threatened, four are Vulnerable, and one Endangered. About 50% of birds were resident, 44% migratory, and 6% local migrants.
Insights into human-wildlife interactions and community views on mangrove restoration in Kendrapada District, Odisha, India
Authors: Qayyum Mohd , Dharmamony Vijai , Manoharakrishnan Muralidharan , Sindura Sadhwi , Sethy Janmejay , Chatakonda Murali Krishna
Published: October 2024

This paper evaluates interactions between humans, Wild Boars, and crocodiles in mangrove ecosystems of the villages of Benakanda, Bhateni, and South Jambu in Mahakalapada Block in the Kendrapada District of the Indian state of Odisha, using questionnaire surveys. This is an area where mangrove restoration is currently in progress. Using a targeted sampling procedure, 280 respondents representing 14% of the population participated in the study. The results show that negative perceptions differ throughout villages, with a majority of respondents reporting interaction between humans and animals in Bhateni (91%) and South Jambu (98%). The most frequent animal reported to cause harm to crop and livelihoods is Wild Boar (44%). Communities understand the value of mangrove restoration despite facing obstacles brought on by interactions with wildlife. The vast majority of residents (87%) believe that restoration efforts were necessary, and many had taken part in these by themselves, or in conjunction with other communities.
Age structure of carp and catfish catch as a tool to assess ecological health of fished stocks from the Ganga River system with special reference to Mahseer Tor tor (Hamilton, 1822)
Authors: Nautiyal Prakash , Dwivedi Amitabh Chandra , Mishra Asheesh Shivam
Published: October 2024

In the 20th centuary, the economically important carp species Labeo rohita, Tor tor, & Labeo calbasu and the catfishes Rita rita & Bagarius bagarius contributed substantially to the total fish catch from the Ganga River system in India. Samples were recorded between December 2003 and June 2004 from fish landing centers in the Ken, Paisuni, and Tons rivers for L. rohita, T. tor and L. calbasu. Rita rita and B. bagarius were sampled between September 2001 and September 2003 in the Ganga River system. The data were used to evaluate the growth and age structures of fish populations. Age classes varied 0+–5+ for L. rohita in the Ken & Paisuni rivers and 0+–8+ in the Tons River. For T. tor, the age classes varied 1+–6+ in the Ken & Paisuni rivers and 1+–8+ in the Tons. Age classes of L. calbasu varied 1+–6+ in the Ken River, 1+–5+ in the Paisuni River, and 1+–7+ in the Tons. In the Ganga River, age classes of R. rita & B. bagarius varied 0+–7+ and 0+–6+, respectively. The L. rohita, age pyramid showed a tendency for bell shape in Ken River, base tends to be broader through bell shape in Paisuni River, and bell-shaped age pyramid was slightly distorted in Tons River. In case of T. tor, tendency for bell shape in Ken River and bell-shaped age pyramid in Paisun River & Tons River were obtained. In case of L. calbasu, heavy bottom shaped age pyramid was recorded in Ken and Paisuni rivers, while base tends to be broader in the Tons River. Bell shaped age pyramid was recorded for B. bagarius in the Ganga River while heavy bottom shape for R. rita in the Ganga River. Overall, T. tor is facing heavy fishing pressure and also targeted fish species by fishermen from the Ganga River system.
A drastic decline in avian diversity in and around the Bordoibam-Bilmukh Bird Sanctuary, Lakhimpur, Assam, India
Authors: Saikia Lakhijyoti , Bora Siddhartha Suman , Khirod Sankar Das
Published: October 2024

Bordoibam-Bilmukh is a small wetland located at the boundary of the Dhemaji and Lakhimpur districts of Assam, India that provides shelter and breeding ground to many resident and migratory birds. A survey was conducted between October 2022 and March 2024 on the avian diversity of Bordoibam-Bilmukh Bird Sanctuary. A total of 47 bird species under 16 orders and 29 families were recorded during the survey. Order Passeriformes, recorded with the highest number of avian species (15). Among the families, the highest number of species (5) was recorded under Ardeidae. Out of all the species recorded, three species, viz., Brown Shrike, Citrine Wagtail, and White Wagtail were winter migratory; one species, the Lesser Kestrel, was summer migratory, and the remaining 43 were resident species. Besides, two species, viz., Lesser Adjutant and Greater Adjutant are listed as ‘Near Threatened’ species on the IUCN Red List. Comparing the avian diversity from 1997 to 2024, a decline in the number of avian species from 167 (as per the 1997 record) to 47 (as per the present study) has been observed in the sanctuary. Various anthropogenic activities such as habitat destruction and disturbance, hunting of birds, are the major causes of the decline of avian diversity. For future species diversity restoration in the sanctuary, these negative anthropogenic activities should be addressed immediately for conservation strategies.
Extended distribution of Trillium govanianum Wall. ex D.Don (Melanthiaceae), an endangered species from Arunachal Pradesh, India
Authors: Kalita Bikash , Roy Saurov Jyoti , Aran Khencha , Sarma Kuladip , Bawri Amal , Sahariah Dhrubajyoti , Tanti Bhaben
Published: October 2024

Trillium govanianum Wall. ex D.Don is an endangered herbaceous species under the family Melanthiaceae, endemic to the Himalayan region of India at an elevation between 2,400–3,500 m. The species is mostly distributed in temperate and sub-alpine zones of the Himalaya. This paper reports an extended distribution of T. govanianum Wall. ex D.Don as a new addition to the flora of Arunachal Pradesh, India for the first time. In the present study, the species was recorded from the Mandala region, West Kameng District of Arunachal Pradesh. Five locations of the individuals of the species were reported and distribution was mapped along with a detailed description and colour photographs provided for the easy identification of the species.
Lung Ultrasound in the Acute Phase of ST‐Segment–Elevation Acute Myocardial Infarction: 1‐Year Prognosis and Improvement in Risk Prediction
Authors: Carreras‐Mora José , Vidal‐Burdeus María , Rodríguez‐González Clara , Simón‐Ramón Clara , Rodríguez‐Sotelo Laura , Sionis Alessandro , Giralt‐Borrell Teresa , Martínez‐Membrive María José , Izquierdo‐Marquisá Andrea , Farré Núria , Cainzos‐Achirica Miguel , Tizón‐Marcos Helena , García‐Picart Joan , Milà‐Pascual Laia , Vaquerizo‐Montilla Beatriz , Rivas‐Lasarte Mercedes , Ribas‐Barquet Núria
Published: October 2024

Background

Lung ultrasound (LUS) has emerged as a useful tool in the acute phase of patients admitted for ST‐segment–elevation myocardial infarction. However, its long‐term significance remains uncertain, and risk scores do not include LUS findings as a predictor. This study aims to assess the 1‐year prognostic value of LUS and its ability to enhance existing risk scores.

Methods and Results

This is a multicenter prospective cohort study involving 373 patients with ST‐segment–elevation myocardial infarction. LUS was performed during the first 24 hours after angiography. LUS results were assessed both as a categorical (wet/dry lung) and continuous variable (LUS score). The primary end point comprised the following major adverse cardiovascular events: all‐cause mortality or hospitalization for heart failure, acute coronary syndrome, or stroke within 1 year. We also evaluated whether LUS could enhance the predictive value of the GRACE (Global Registry of Acute Coronary Events) score. Major adverse cardiovascular events occurred in 51 (13.7%) patients over a median follow‐up of 368 days. After multivariate analysis, the LUS score was an independent predictor (hazard ratio [HR], 1.06 [95% CI, 1.01–1.10];
P
=0.009] for each additional B‐line), whereas the categorical classification was an independent predictor in patients with ST‐segment–elevation myocardial infarction Killip I (HR, 3.12 [95% CI, 1.34–7.31];
P
=0.009). Incorporating LUS into GRACE resulted in a net reclassification index of 31.6% and a significant increase in the area under the curve; GRACE alone scored 0.705 compared with GRACE+LUS 0.791 (
P
=0.002).

Conclusions

Detecting B‐lines on LUS at the acute phase predicts major adverse cardiovascular events at 1 year in patients with ST‐segment–elevation myocardial infarction and enhances the predictive value of the GRACE score.

REGISTRATION: URL:

https://www.clinicaltrials.gov
; Unique identifier: NCT04526535.
Safety and Effectiveness of Low‐Density Lipoprotein Cholesterol–Lowering Therapy With Evolocumab for Familial Hypercholesterolemia/Hypercholesterolemia in Japan: A Real‐World, Postmarketing, Single‐Arm Study
Authors: Yokote Koutaro , Ako Junya , Kitagawa Kazuo , Osada Nobuhiro , Sheng Feng , Sonoda Masae , Teramoto Tamio
Published: October 2024

Background

Evolocumab is the first monoclonal antibody against proprotein convertase subtilisin/kexin type 9 approved in Japan for familial hypercholesterolemia (FH) and hypercholesterolemia; however, data on its safety and effectiveness in the real‐world setting in Japan are limited.

Methods and Results

This real‐world, postmarketing, single‐arm study assessed the safety and effectiveness of low‐density lipoprotein cholesterol lowering with evolocumab in patients with homozygous/heterozygous familial hypercholesterolemia and hypercholesterolemia with high risk in Japan (668 sites). The primary safety end point was the incidence (percentage) and number of patients with adverse drug reactions and serious adverse events during the 104‐week follow‐up. Primary effectiveness end points included the percentage change in low‐density lipoprotein cholesterol levels from baseline to week 12, assessed using 2‐sided paired
t
tests. The safety and effectiveness sets comprised 3724 (homozygous FH, n=108; heterozygous FH, n=2009; hypercholesterolemia with high risk, n=1607) and 2797 (homozygous FH, n=91; heterozygous FH, n=1615; hypercholesterolemia with high risk, n=1091) patients, respectively. Overall, mean age and disease duration were 63.2 and 12.3 years, respectively. Serious adverse drug reactions and serious adverse events were experienced by 0.5% and 10.3% of patients; the incidence rates of myocardial infarction and stroke were 0.7% and 0.3%, respectively. A significant mean±SD percentage change in low‐density lipoprotein cholesterol levels was observed at week 12 among patients with homozygous FH (−45.7%±28.2;
P
<0.001), heterozygous FH (−55.9%±28.8;
P
<0.001), and hypercholesterolemia with high risk (−63.3%±23.7;
P
<0.001).

Conclusions

Evolocumab was well tolerated, and real‐world patients with familial hypercholesterolemia and hypercholesterolemia with high risk in Japan had sustained low‐density lipoprotein cholesterol reduction.

REGISTRATION

URL:
https://www.clinicaltrials.gov
; Unique Identifier: NCT02808403.
Cardiomyocyte‐Specific Overexpression of Activated Yes‐Associated Protein Modified‐RNA Promotes Cardiomyocyte Proliferation and Myocardial Regeneration
Authors: Wang Yongyu , Wu Yalin , Jiang Yu , Tan Huilan , Guragain Bijay , Nguyen Thanh , Zhao Jianli , Zhou Yang , Nakada Yuji , Zhang Jianyi
Published: October 2024

Background

The proliferative capacity of cardiomyocytes in adult mammalian hearts is far too low to replace the cells that are lost to myocardial infarction. Both cardiomyocyte proliferation and myocardial regeneration can be improved via the overexpression of a constitutively active variant of YAP5SA (Yes‐associated protein, 5SA [active] mutant), but persistent overexpression of proliferation‐inducing genes could lead to hypertrophy and arrhythmia, whereas off‐target expression in fibroblasts and macrophages could increase fibrosis and inflammation.

Methods and Results

Transient overexpression of YAP5SA or GFP (green fluorescent protein; control) was targeted to cardiomyocytes via our cardiomyocyte‐specific modified mRNA translation system (
YAP5SA
CM‐SMRTs or
GFP
CM‐SMRTs, respectively). YAP5SA‐cardiomyocyte specificity was confirmed via in vitro experiments in cardiomyocytes and cardiac fibroblasts that had been differentiated from human induced‐ pluripotent stem cells and in human umbilical‐vein endothelial cells, and the regenerative potency of
YAP5SA
CM‐SMRTs was evaluated in a mouse myocardial infarction model. In cultured human induced‐pluripotent stem cells‐cardiomyocytes, YAP was abundantly expressed for 3 days after
YAP5SA
CM‐SMRTs administration and was accompanied by increases in the expression of markers for proliferation, before declining to near‐background levels after day 7, whereas GFP fluorescence remained high from days 1 to 3 after
GFP
CM‐SMRTs treatment and then slowly declined. GFP fluorescence was also observed in human induced‐pluripotent stem cells‐cardiac fibroblasts and human umbilical‐vein endothelial cells on day 1 after
GFP
CM‐SMRTs administration but declined substantially by day 3. In the mouse myocardial infarction model, echocardiographic assessments of left‐ventricular ejection fraction and fractional shortening were significantly greater, whereas infarct sizes were significantly smaller in
YAP5SA
CM‐SMRTs–treated mice than in vehicle‐treated control animals, and
YAP5SA
CM‐SMRTs appeared to promote cardiomyocyte proliferation.

Conclusions

The CM‐SMRTs can be used to transiently and specifically overexpress YAP5SA in cardiomyocytes, and this treatment strategy significantly promoted cardiomyocyte proliferation and myocardial regeneration in a mouse myocardial infarction model.
Characterizing Nonculprit Lesions and Perivascular Adipose Tissue of Patients Following Acute Myocardial Infarction Using Coronary Computed Tomography Angiography: A Comparative Study
Authors: Wang Xiaomeng , Sia Ching H. , Adamson Philip D. , Greer Charlotte E. , Huang Weimin , Lee Hwee K. , Leng Shuang , Loong Yan T. , Raffiee Nur A. S. , Tan Swee Y. , Tan Sock H. , Teo Lynette L. S. , Wong Sung L. , Yang Xiaoxun , Yew Min S. , Yong Thon H. , Zhong Liang , Shaw Leslee J. , Chan Mark Y. Y. , Hausenloy Derek J. , Baskaran Lohendran
Published: October 2024

Background

The comparison of coronary computed tomography angiography plaques and perivascular adipose tissue (PVAT) between patients with acute myocardial infarction (AMI) posttreatment and patients with stable coronary artery disease is poorly understood. Our objective was to evaluate the differences in coronary computed tomography angiography–quantified plaque and PVAT characteristics in patients post‐AMI and identify signs of residual inflammation.

Methods and Results

We analyzed 205 patients (age, 59.77±9.24 years; 92.20% men) with AMI ≤1 month and matched them with 205 patients with stable coronary artery disease (age, 60.52±10.04 years; 90.24% men) based on age, sex, and cardiovascular risk factors. Coronary computed tomography angiography scans were assessed for nonculprit plaque and vessel characteristics, plaque volumes by composition, high‐risk plaques, and PVAT mean attenuation. Both patient groups exhibited similar noncalcified plaque volumes (383.35±313.23 versus 378.63±426.25 mm
3
,
P
=0.899). However, multivariable analysis revealed that patients post‐AMI had a greater patient‐wise noncalcified plaque volume ratio (estimate, 0.089 [95% CI, 0.053–0.125],
P
<0.001), largely attributed to a higher fibrofatty and necrotic core volume ratio, along with higher peri‐lesion PVAT mean attenuation (estimate, 3.968 [95% CI, 2.556–5.379],
P
<0.001). When adjusted for vessel length, patients post‐AMI had more high‐risk plaques (estimate, 0.417 [95% CI, 0.298–0.536],
P
<0.001) per patient.

Conclusions

Patients post‐AMI displayed heightened noncalcified plaque components, largely due to fibrofatty and necrotic core content, more high‐risk plaques, and increased PVAT mean attenuation on a per‐patient level, highlighting the necessity for refined risk assessment in patients with AMI after treatment.
Reimagining Cryptogenic Stroke Care: Collaborative Care and Inpatient Insertable Cardiac Monitors for Detection of Atrial Fibrillation
Authors: Herial Nabeel A. , Frisch Daniel R. , Miller Elan , Patel Priyadarshee , Munoz Alfredo , Warren Melissa , Khalife Jane , Majmundar Shyam , Farkas Nathan , Alam Shaista , Dharia Robin , Tzeng Diana , Pavri Behzad B. , Ho Reginald T. , Greenspon Arnold , Bell Rodney , Jabbour Pascal , Rosenwasser Robert
Published: October 2024

Background

Atrial fibrillation (AF) is a known risk factor of ischemic stroke, and AF‐related stroke is twice more likely to be fatal. Long‐term cardiac rhythm monitoring using insertable cardiac monitors (ICMs) has greater diagnostic yield compared with conventional monitoring in detecting AF, and the clinical utility of ICMs is established in cryptogenic stroke, strokes attributable to large‐artery atherosclerosis, and strokes attributable to small‐vessel disease. A registry‐based study was conducted to evaluate the inpatient implantation of ICMs and the feasibility of vascular and interventional neurologists as implanters using novel collaborative clinical care pathway for cryptogenic stroke.

Methods

Multiyear data from a hospital‐based registry at a comprehensive stroke center were reviewed to evaluate inpatient ICM implantation and test feasibility of vascular and interventional neurologists as implanters of ICMs together with cardiology using a novel collaborative care pathway. Reviewed data included the number of ICMs, implantation trend, inpatient versus outpatient setting, time to ICM implantation, inpatient workflow, including defined roles of team members, and AF detection rate.

Results

A total of 290 ICMs for cryptogenic stroke were implanted when patients were in the hospital and 78 as outpatients after discharge during the study period of 3 years. Most inpatient ICM implants were performed by vascular and interventional neurology (n = 181), and ICM use for cryptogenic stroke increased by 130%. The average time to inpatient ICM implant was 4.1 days, with 77% in 5 days and 95.5% within 10 days poststroke. The average time to out‐patient ICM placement was 57 days. AF detection rate of 36.5% was noted at 24 months with a collaborative care pathway.

Conclusion

Inpatient implantation of ICMs is feasible and was performed safely and efficiently by vascular and interventional neurology together with cardiology using a collaborative care pathway. An increase in use of ICMs and higher AF detection rates were noted. Findings support innovative efforts to improve access and close the gaps in the delivery of cryptogenic stroke care to ultimately reduce the secondary stroke burden.
Environmental Rights and the Impact of Climate Change within the Committee on the Rights of the Child Concluding Observation Reports
Authors: MacDonald Fiona
Published: October 2024

In recent years, there has been an increasing global focus on climate change and environmental issues. Although there are only two articles that refer to environmental health and none to climate change in the Convention on the Rights of the Child, the UN Committee has considered these subjects to be children’s rights issues.

Presented here is a summary of the findings from an empirical study demonstrating the increasing frequency of comments relevant to environmental issues and climate change within the Concluding Observation reports from the Committee on the Rights of the Child from 2000 to 2022 before the introduction of the new General Comment No. 26. It is further established that though relevant comments occur within all rights clusters, it is the health cluster and under the general measure of implementation where these are mainly focused, with access to clean water and sanitation being the primary issue.
The Role of Judicial Powers in Guaranteeing the Right to Education: A Systematic Study of Litigation in Mexico
Authors: Zorrilla Noriega Ana María , Orozco Sofía Charvel , Cobo-Armijo Fernanda
Published: October 2024

This article aims to analyse the role of Mexican District Courts in cases related to the education sector and, specifically, the stance courts take on guaranteeing the right to education. The study is conducted through thematic and frequency analysis of judgments available from indirect amparo trials in administrative and labour matters across the 32 judicial circuits in Mexico during 2019, 2020 and the first semester of 2021. This study arises from the need to understand, from the perspective of judicialisation, the impact that the Mexican education sector has faced in the context of approved structural reforms in recent years, the problems of quality and equality experienced, and any exacerbations provoked by the covid-19 pandemic. The article’s discussion centres on certain paradigmatic and particularly relevant cases for the protection of children’s right to education in Mexico, including the examination of both the claims presented by the claimants and the arguments developed by the adjudicating institutions.
Theorising Relationships and Sex Education (rse) as a Children’s Rights Issue Using A Foucauldian Lens
Authors: Heah Rachel
Published: October 2024

This article seeks to analyse the problems with provision of Relationships and Sex Education (rse) in English schools using a Foucauldian perspective. Through this analysis, I demonstrate that the rse curriculum is used as a tool for “governing” or controlling children’s exercise of their sexuality to ensure conformity with norms, behaviours and attitudes that adults perceive children should ascribe to. However, adults tend to deny children’s developing agency and their autonomy to make decisions in relation to their sexual lives. This ignores the realities of children’s lives, in which they are exposed to sexual knowledge and information through their interactions with others, or via the internet. Using Foucault’s conceptualisation of bio-power, I argue for shifting some of the power around rse discourses from adults to children themselves, through a children’s rights-based approach. This approach to rse will ensure that the curriculum is adequate, appropriate and effective for children.
From Grievances to Growth
Authors: Shah Mehdi , Turi Abdullah
Published: October 2024

Past animosities and complex geopolitics make the Israel-Palestine conflict complex and require a multifaceted approach. As modernization theory fails to address such conflicts, we combine post-colonial theory, identity politics, critical geopolitics, with modernization theory to provide a more complete picture. A comprehensive strategy for building a strong and united Palestinian society is presented in this paper, which emphasizes democratic changes, military power rebalancing, international law, and economic independence. Education and technological progress drive societal growth, so strong governance systems are essential for political stability. We demonstrate how these methods work and what are their drawbacks by analyzing real-life examples of how social, economic, and political factors affect conflict. In the study, governments, civil society, and international organizations are a key focus for finding a long-term solution. This extensive research on conflict resolution and growth expands the conversation and offers lessons that can be applied to various conflict situations.
Text-Fabric Dataset of the Samaritan Pentateuch
Authors: Naaijer Martijn , Højgaard Christian Canu , Schorch Stefan , Ehrensvärd Martin
Published: October 2024

In this article, the authors present a dataset of the text of the Samaritan Pentateuch with word-level linguistic annotations. The Samaritan Pentateuch is an important early witness of the Pentateuch or Torah. This dataset is based on a transcription generally taken from manuscript Dublin, Chester Beatty Library 751 (Genesis 1:1–Deuteronomy 32:36) and supplemented from manuscript Nablus (Kiryat Luza), Samaritan Synagogue, Garizim 1, where the former manuscript has not preserved the text (Deuteronomy 32:36b–34:10). The dataset is a Text-Fabric dataset. Text-Fabric is a Python package for processing annotated text corpora, which means that the dataset comes with an app, where the text can be inspected and queried using the annotations. It is also easy to perform textual and linguistic research using Python scripts and to make comparisons with other relevant textual datasets with the same annotation conventions.
The Principle of Suspension (bādha) in Early Mīmāṃsā: the Case of prāpta- and aprāptabādha
Authors: Ferrante Marco , Freschi Elisa
Published: October 2024

This article examines the notion of bādha or ‘suspension’, one of the primary hermeneutical devices the Mīmāṃsā school of Sanskrit philosophy implemented to avoid seeming clashes between different commands of the Veda. Through bādha, a Vedic injunction can temporarily be suspended to allow for the unchallenged application of another. In all other cases, the first command remains valid, and its authority is therefore not undermined. This essay analyses the history of the device within early Mīmāṃsā, elaborates on how to decide which of two clashing commands should be suspended, and examines the crucial distinction between a suspension of something ‘obtained’ and that of something that is ‘not obtained yet’.
Towards an Intellectual History of Cakravartin Kingship
Authors: Shirley Bruno M.
Published: October 2024

Cakravartin kingship has long been treated as an ahistorical constant in histories of premodern Southern Asia. This paper argues for an intellectual history of cakravartinship, based not on its articulation in supposedly authoritative texts—particularly Buddhist suttas—but instead on what I call a “genealogy of practice,” traced primarily through the inscriptional record. Such a genealogy suggests that the mid-eleventh century served as a watershed moment for cakravartin claims: across the Indian Ocean, across “religious” boundaries, and across vernacular languages.
‘Turkmen’ Sultan, Armenian Deputy?
Authors: Leube Georg
Published: October 2024

This article reconstructs the positionality of an individual bearing the Armenian name Arewšah, as well as the Turkic name Khwushqadam, who supported the refoundation of an Armenian Christian monastery at Erkan in ca. 1430 CE. He is stated to have supported this refoundation in his capacity as local governor (nāʾib) serving the Muslim Aqquyunlu ruler qara ʿUthmān. Based on a detailed survey of the notes of possession contained in the unique manuscript that praises the patronage of Arewšah / Khwushqadam at Erkan, I suggest that he originally hailed from the area around the town of Hizan / Bitlis south of Lake Van, before assuming a governorship in Aqquyunlu Dersim. Although the name Arewšah is not attested in Aqquyunlu court historiography, I conclude with the suggestion that he could be identical to the Khwushqadam bīk b. ʿAbdalʿazīz who is mentioned among Aqquyunlu leaders between ca. 1435 and 1455 CE.
The first firefly fossil (Coleoptera: Lampyridae) from Dominican amber
Authors: ROZA ANDRÉ SILVA , KUNDRATA ROBIN , KUSY DOMINIK , LIAN ZHEN-DONG , LIMA DA SILVEIRA LUIZ FELIPE
Published: October 2024

Fireflies (Coleoptera: Lampyridae) comprise ~2,500 extant species worldwide (Ferreira et al., 2020). Considering the extant diversity of firefly species, their fossil record is scant, with only eight taxa across four subfamilies: Luciolinae, Ototretinae, Lamprohizinae, and Lampyrinae (Supplementary file 1; Kazantsev, 2024). Dominican amber may have the best quality of preservation among fossil resins, with a rich diversity of fossil specimens (Grimaldi & Engel, 2005) from the early Miocene (20–15 Ma) (Iturralde-Vinent & MacPhee, 2019). However, no firefly taxon was previously known from this deposit. Here, we describe the first Lampyridae fossil from Dominican amber. It represents a new species of the extant Neotropical genus Lychnacris Motschulsky, 1853, which has 19 extant species known from the island of Hispaniola in the Caribbean (Kazantsev & Perez-Gelabert, 2009, 2013; Perez-Gelabert, 2011).
Archaic sap beetles (Coleoptera: Nitidulidae) as Cretaceous pollinators
Authors: PERIS DAVID , JELÍNEK JOSEF , SABATELLI SIMONE , LIU MEI-KE , PEÑA-KAIRATH CONSTANZA , ZHAO QIAN , CAI CHEN-YANG , KAIRIŠS KRISTAPS , MÄHLER BASTIAN , RÜHR PETER T. , HAMMEL JÖRG U. , AUDISIO PAOLO
Published: October 2024

Kateretidae have been considered a family of generalist (as a whole) fossil pollinator beetles after the description of many fossil species in this taxon from the Upper Cretaceous Kachin amber together with pollen grains from their host plant. But the placement of this group of fossils in Kateretidae remained tentative because some definite characters to be observed in the fossils (e.g., maxillae and genitalia) were almost inaccessible by conventional methods. A recent paper proposed to include most of these fossil “kateretid” genera and species in the newly erected family Apophisandridae among Cucujoidea. The description of the two new genera and species Diopsiretes corniger gen. et sp. nov. and Cornuturetes elaphus gen. et sp. nov. from the same deposit, and the use of synchrotron light to describe the first cited species, combined with the examination of new photographic material of the type of Apophisandra ammytae, allowed us to better define this peculiar group of fossils. We attempt to demonstrate their placement in an extinct basal subfamily in Nitidulidae (Apophisandrinae stat. nov.), with some partially shared plesiomorphic characters of both Kateretidae and Nitidulidae: Epuraeinae, and with a series of convergent morphological characters also shared with other extant anthophagous nitidulids including Nitidulinae: Mystropini and Meligethinae. As such, all the fossil species from the Kachin amber initially described in Kateretidae and recently moved to Apophisandridae, should be included in Nitidulidae: Apophisandrinae.
Arthropod coprolites and wound reaction in the late Paleozoic climbing fern Hansopteris
Authors: LI FENG-YAN , FENG ZHUO , PŠENIČKA JOSEF , WANG JUN , ZHOU WEI-MING
Published: October 2024

Interactions between arthropods and plants have been documented extensively in late Paleozoic trees and ground cover plants, but they have rarely been recorded in late Paleozoic climbers. In this study, we present the second example of coprolites preserved within the plant tissue from the early Permian fossil Lagerstätte Wuda Tuff Flora. The host axis is identified as a phyllophore of the climbing fern Hansopteris uncinatus by the combined evidence of anatomy, morphology, and associated plants. Unlike the first coprolites, which were suggested to be produced by oribatid mites, the culprit of the studied coprolites was likely a myriapod or beetle, indicated by their slightly larger size and the boring behaviour. Furthermore, anomalous parenchymatous cells, sclerenchymatous cells, and metaxylem tracheids have been observed surrounding the tunnel, suggesting responses to traumatic stimulus caused by arthropod damage. This discovery provides an informative example of arthropod herbivory on late Paleozoic climbers and sheds light on how the host plant responded during the early stage of injury.
Resolving the ongoing confusion between Erigeron multiradiatus and Tibetiodes himalaica (Asteraceae)
Authors: BHATTACHARJEE AVISHEK , BHATTACHARJEE BANDANA , CHAKRABORTY KASTURI , BANU FARHEEN , SHERPA NORBU , LAYOLA M.R. RANJITH
Published: October 2024

Erigeron multiradiatus (Asteraceae: Astereae: Conyzinae) and Tibetiodes himalaica (Asteraceae: Astereae: Asterinae) are often misidentified due to their morphological similarity and variation in some morphological characters. The present communication aims to resolve the identity crisis of these two species based on detailed morphological studies of freshly collected as well as herbarium specimens (including types), SEM studies of cypselas and molecular study with one nuclear and one chloroplast marker (ITS and trnLF). The morphological analysis showed that the two species differ in involucres and flower colour, with very clear differences in macro- and micro-morphological features of the cypselas. The molecular study also showed clear distinction between these two taxa. Additionally, a lectotype is designated for Erigeron multiradiatus.
Constellation of the Five Constant Virtues in English Translations of The Analects
Authors: Fu Shiwei
Published: October 2024

The five constant virtues (rén, yì, lǐ, zhì, and xìn) are central to Confucian philosophy and have grown in influence over time, shaping not only traditional moral teachings but also contemporary practices in business management and personal development. However, limited research has explored how these virtues are translated and conceptualized in English versions of The Analects. This study aims to address this gap by examining how the five constant virtues are formed, related, and legitimized across four major English translations, spanning different historical periods. To achieve this, a mixed-methods approach is employed, integrating both qualitative and quantitative analyses. First, a multi-parallel corpus is established, enabling a detailed quantitative examination of how the five constant virtues are expressed across different translations. This analysis highlights variations in the rendering of these key concepts in each text. In parallel, Legitimation Code Theory’s (LCT) constellation analysis is applied for the qualitative component of the study. This approach explores the relationships among the virtues and how translators have conceptualized and structured these interrelations. Results indicate a reduction in variation over time, suggesting a stabilization in how the virtues are conceptualized. While translations consistently represent simpler pairings of virtues, differences emerge when more complex constellations involving all five elements are considered. These findings reveal how philosophical perspectives and temporal contexts shape translation, impacting the way Confucian virtues are legitimized and structured.
Development of a framework of the skills and attributes needed by mental health professionals to provide optimal clinical care to people experiencing complex psychosis: A Delphi consensus study
Authors: Grattan Sarah , Davies Kimberley , Weise Janelle , Burns Nicholas , Murray Robyn , Weldon Jennifer , Ellis Robin , Lappin Julia M
Published: October 2024

Background:

Complex psychosis is associated with high social and economic costs. The key skills and attributes needed by mental health professionals to provide optimal clinical care to people experiencing complex psychosis have not previously been defined. A framework detailing these skills and attributes is needed to support the identification of training needs for those working with this population.

Methods:

A modified online Delphi method was used to reach consensus on the skills and attributes essential for mental health professionals to deliver optimal clinical care to people experiencing complex psychosis. Participants were international healthcare professionals and academic researchers who self-identified as experts in complex psychosis. Participants were asked to rate their level of agreement with each item on a five-point Likert-type scale and to provide comments. Qualitative feedback was used to modify existing, or create new, items for subsequent rounds.

Results:

64 responses were received across three Delphi rounds. 167 items reached consensus and were endorsed (132 in Round 1, 31 in Round 2 and 4 in Round 3). Median score range for endorsed items was 4.5/5, with 88.6% scoring 5/5. All 167 endorsed items were included in the framework, categorised into 14 overarching domains.

Conclusion:

Multiple skills and attributes were identified as being core components required in the delivery of optimal care by mental health professionals to people experiencing complex psychosis. The resulting framework provides a benchmark for training and skill development of mental health clinicians at both individual and team levels to optimise effective working with this high-needs population.
Predicting Drowsy Driver Break Taking During Long Drives
Authors: Gaspar John G. , Tefft Brian , Carney Cher , Horrey William J.
Published: October 2024

Objective

The current study investigated the factors that predict drowsy drivers’ decisions regarding whether to take breaks versus continue driving during long simulator drives.

Background

Driver drowsiness contributes to substantial numbers of motor vehicle crashes, injuries, and deaths. Previous research has shown that taking a nap and consuming caffeine can temporarily mitigate drowsiness and enable continued safe driving.

Method

Ninety drivers completed a 150-mile highway drive in a driving simulator after a day of partial sleep restriction. Drivers passed several simulated rest areas where they could take breaks. To replicate drivers’ motivation to reach their destination safely but also quickly, drivers were told that they would be paid more for completing the simulated drive faster but would forfeit their payment if they crashed.

Results

Break taking was predicted by drivers’ self-ratings of drowsiness and by the severity of lane departures. However, even at the highest levels of drowsiness, most drivers bypassed simulated rest areas without stopping. In comparing self-rated drowsiness to drowsiness measured by eye closures, drivers often under- and over-estimate their own level of drowsiness.

Conclusion

Drowsy drivers use their own self-assessed drowsiness when deciding whether to take breaks. These self-assessments are often incorrect, and even when drivers rate themselves as severely drowsy they are unlikely to stop to rest during long drives.

Application

The findings reveal the need for effective drowsy driving countermeasures to motivate drivers to stop to take breaks. Results underscore the need to educate and/or motivate drivers to respond sooner to warning signs of drowsiness.
Shadowplay: Journeys to Our Abandoned Selves
Authors: Easton Dossie
Published: October 2024

Role-playing is a common practice within the bounds of kink, fetish, and/or BDSM erotic encounters. The application of Jungian Shadow concept to the erotic or SM role-play practices is explored in this article, which is an update to the author’s 2007 chapter Shadowplay: SM journeys into ourselves. Areas such as past trauma, cultural trauma, issues around gender and power, and therapeutic aspects of engaging in role-play in the context of BDSM encounters are explored.
Open Space and Ocean Grabbing: The Sea in the Geographic Opening of the Galápagos
Authors: Grenier Christophe
Published: October 2024

The sea has long been a barrier guaranteeing the ecological isolation of the Galápagos. When Ecuador annexed the archipelago, the sea became an obstacle, because neither the state nor the island residents had ships to maintain regular relations with the mainland. On the contrary, the Galápagos Islands are an open space for foreign actors who, having adequate transport, freely use its natural resources and strategic location. At the end of the twentieth century, air travel overcame the oceanic distance and led to the unlimited development of maritime and land tourism in the archipelago’s protected areas. The needs of the Galápagos’ growing population are supplied by cargo ships and, through a process of ocean grabbing, its sea is exploited by various forms of tourism and export fishing. The sea is thus the main vector of the geographical opening of the Galápagos, a process characteristic of globalization that causes profound spatial, ecological, and social changes in a once isolated region.
Armed Forces as an Employer of Choice: The Role of Gender and Person–Organization Fit
Authors: Otis Nancy , Connick-Keefer Sarah Jayne A.
Published: October 2024

Many militaries are facing challenges in meeting recruitment goals and increasing the number of women in their ranks. The objectives of this study were to examine the gender-specific associations between Armed Forces (AF) employer knowledge dimensions (i.e., familiarity, job attributes, and reputation) and AF attractiveness as an employer as well as to assess the moderating effects of person–organization fit (P-O fit) between these associations. Participants included 1,955 potential applicants who completed an online survey on the Canadian Armed Forces’ image. Results from multiple-group analyses showed that P-O fit was the factor most strongly associated with AF attractiveness for both men and women. Results also suggested that P-O fit plays a moderating role for women in that a minimum level of P-O fit is necessary for perceived work–life benefits in the AF to positively affect attraction to a military career.
Design of active disturbance rejection controller for the system with unknown model using Laguerre functions
Authors: Zhang Pengcheng , Wang Jianyu , Lee Sangmoon , Cheng Yun
Published: October 2024

This paper concentrates on the design problem of linear active disturbance rejection control (LADRC) for uncertain systems, whose order and parameters are unknown. In general, LADRC has diversified structural forms due to different order and parameters selection. To clarify the prerequisites for constructing the LADRC strategy, a Laguerre-based LADRC (LLADRC) method is proposed, which provides controller design guidance for systems with unknown models by capturing the impulse response. Then, intensive attention is focused on establishing internal stability conditions of the feedback system and parameter tuning rules of the prescribed controller. To gain a better understanding, the internal correlation between LLADRC and standard LADRC of the same order is analyzed. It is shown that observer and controller gains of the standard LADRC can be tuned via a workable LLADRC to achieve better control performance. Finally, a numerical example and an application design of DC motor speed control are studied, both of which demonstrate the feasibility and validity of the proposed method.
Identifying DNA Variants in a Turkish Cohort with Inner Ear Anomalies
Authors: Yilmaz Umit , Yildirim Baylan Müzeyyen , Duman Duygu , Sineni Claire , Bademci Güney , Sizer Bilal , Tekin Mustafa
Published: October 2024

To determine the genetic causes of sensorineural hearing loss (SNHL) associated with inner ear anomalies, 11 unrelated Turkish individuals diagnosed with SNHL and an inner ear anomaly using temporal bone computed tomography and inner ear magnetic resonance imaging underwent exome or whole genome sequencing to identify underlying genetic defects. None of the individuals was diagnosed with a recognized syndrome. Four of the 11 probands were homozygous for SLC26A4 variants, c.283G>A, c.845G>A, c.1061T>C, and c.1198delT. Another proband was homozygous for a TECTA variant, c.4163G>A. Patients with variants of the SLC26A4 gene had bilateral enlarged vestibular aqueduct, bilateral incomplete partition type 2 anomaly, bilateral hypoplastic cochlea and bilateral enlarged vestibular aqueduct plus hypoplastic cochlea anomaly. Patients with the variant TECTA gene had bilateral hypoplastic cochlea. This study identified variants of SLC26A4 in 36% of probands with inner ear anomalies. While we identified a variant of the TECTA gene in a proband with cochlear hypoplasia, further studies are needed to see if TECTA variants can cause cochlear malformations.