bluuebunny/crossref_metadata_2025 huggingface dataset:
Permissive Hypercapnia and Hypercapnic Hypoxia Inhibit the Signaling Pathways of Neuronal Apoptosis in Ischemic/Hypoxic Rats
Authors: Tregub Pavel , Malinovskaya Natalia , Hilazheva Elena , Morgun Andrey , Kulikov Vladimir
Published: June 2022

Introduction: The present study aimed to test the hypothesis that hypercapnia, independently and/or in combination with hypoxia, can activate the signaling pathways for adaptation to hypoxia/ischemia related to inhibiting proapoptotic (caspase-dependent and caspase-independent) and inducing antiapoptotic factors. Methods: Following exposure to permissive hypercapnia and/or normobaric hypoxia, the intensity of apoptosis was evaluated in experimental ischemia models in vivo and in vitro. The percentages of caspase-3, apoptosis-inducing factor (AIF), Bax, and Bcl-2 in astrocytes and neurons derived from male Wistar rats were also calculated. In vitro, cells were subjected to various types of respiratory exposure (hypoxia and/or hypercapnia for 24 or 12 hours), as well as further sublethal chemical hypoxia. The percentages of these molecules in nerve cells in the ischemic penumbra of the brain after photothrombotic injury were also calculated. Results: It was established that the intensity of apoptosis decreased in the ischemic penumbra, mostly due to the hypercapnic component. It was also discovered that the levels of caspase-3, AIF, and Bax decreased in this area, whereas the level of Bcl-2 increased following exposure to hypercapnia and hypercapnic hypoxia. Discussion: The integrative assessment of the intensity of apoptosis/necrosis in astrocyte and neuron cultures showed that a combination of hypercapnia and hypoxia had the maximum neuroprotective effect. The levels of the mediators of apoptosis in astrocyte and neuron cultures after modeling chemical hypoxia in vitro were calculated. According to the results, the exposure modes combining permissive hypercapnia and normobaric hypoxia also have the most pronounced inhibitory effects on the apoptotic signaling pathways.
Mechanism causing the spatial distribution non- uniformity of the prompt optical crosstalk effect in G- APD cells of Multi-Pixel Photon Counters
Authors: Cao XinYue , Zhang Guoqing , Yang Yaxian , Zhang Chen , Liu Lina , Zhang Chunling , Li Lianbi , Gallina Giacomo
Published: June 2022

The optical crosstalk effect in Multi-Pixel Photon Counters (MPPC) is unnecessary parasitic effects. The mechanism leading to the non-uniform spatial distribution of the prompt optical crosstalk in MPPCs was investigated in detail herein. The experimental results showed that the optical crosstalk probability (Pct) in MPPCs without optical isolation trenches was clearly non-uniform within the Geiger-mode avalanche photodiode (G-APD) cell. However, the spatial distribution uniformity of Pct in G-APD cells was improved significantly in an MPPC containing optical isolation trenches. The different propagation distances of crosstalk photons emitted from different positions of the source G-APD cell to the nearest neighboring G-APD cell along a straight line, were the main reason for the non-uniform spatial distribution of Pct in the MPPC. According to the experimental results, it can also be inferred that the emission of crosstalk photons is spatially localized during a G-APD cell’s avalanche event, and majority crosstalk photons are emitted during the early stage of the avalanche.
Exploring the possibilities of non-covalently cationized nanocellulose for papermaking
Authors: Aguado Roberto , Tarrés Quim , Mutjé Pere , Pèlach M. Àngels , Delgado-Aguilar Marc
Published: June 2022

As cationic cellulose, despite its long history, has yet to find a place in the paper industry, recent research is assessing the potential of its nanoscale forms. We combined this trend with the existing knowledge of the strong adsorption of poly(diallyldimethylammonium chloride) (polyDADMAC) on cellulosic fibers, which can be deemed a non-covalent kind of cationization. For that, polyDADMAC was first anchored to refined kraft pulps from hemp, under conditions that allowed the deprotonation of the hemiacetal groups of cellulose. Conveniently, a highly positively-charged fiber surface remained after thoroughly washing the samples, owing not only to the small proportions of acidic hemicelluloses and lignin, but also to stable ion-dipole interactions. This non-covalent cationization was found to follow pseudo-second order kinetics, indicating that diffusion through the fiber is the rate-controlling step. PolyDADMAC-containing fibers were then fibrillated by high-pressure homogenization. Far from promoting desorption, cationic nanocellulose had greater surface charge than the starting fibers, as the specific surface area increased. Nonetheless, polyDADMAC caused agglomeration of fibrils to a certain extent, resulting in, besides loss of transparency, higher permeability when applied in papermaking by bulk addition. As an advantage, the tensile index increased by up to 57% in the absence of any retention agent.
Fermentation performance of Bacillus subtilis wild type and alsS- mutant using different carbon sources
Authors: Carreón-Rodríguez Ofelia E , Gosset Guillermo , Martinez Alfredo
Published: June 2022

Bacillus subtilis can metabolize a wide array of sugars under aerobic conditions, including hexoses via the EMP pathway and some pentoses via the pentose phosphate pathway, and secretes amylases, cellulases and hemicellulases. However, studies using different sugars under anaerobic conditions are scarce. B. subtilis can also grow anaerobically by using a terminal electron acceptor or by fermentation metabolizing glucose to lactic acid (LA), butanediol, and other products under non-aerated conditions. B. subtilis ER382 (∆alsS), with the 2,3-butanediol pathway inactivated, was obtained from strain 168 trp+. Such deletion allowed obtaining a homo l-lactogenic strain with increased LA production. B. subtilis ER382 was evaluated in batch cultures with 10 g/L of seven different carbon sources under non-aerated conditions and rich media. B. subtilis ER382 metabolized glucose, fructose, cellobiose, sucrose, and arabinose under non-aerated conditions and produced LA as the only fermentation product. However, strains 168 trp+ and ER382 were unable to ferment and grow on glycerol or starch under the tested conditions. The higher biomass yield and faster rates of sugar consumption (1.01 gSUGAR/L h) and L-LA production (1.32 gLA/L h) were obtained with glucose as the carbon source and the strain containing the alsS deletion. The L-LA yield on consumed sugars was above the theoretical because carbon sources from yeast extract and amino acids from casein hydrolysate were also used for LA synthesis.
Predicting adverse pregnancy outcomes of pregnant mothers with syphilis based on a logistic regression model: a retrospective study
Authors: Zhang Yu-Wei , Liu Man-Yu , Yu Xing-Hao , He Xiu-Yu , Xu Xiao-Hang , Wang Dong , Liu Xiao , Ma Ya-na
Published: June 2022

Objective: To assess whether a simple predictive model can be composed of risk factors leading to adverse pregnancy outcomes (APOs) in infants of syphilitic mothers during pregnancy, that can predict the APOs of newborns.Methods: We conducted a retrospective study of 768 pregnant women with syphilis. They were required to complete a questionnaire. We analyzed the data and divided it into a training set and a test set. In the training set, we screened the predictors, constructed a prediction model and evaluated the prediction performance in the test set.Results: Compared with the APOs group, pregnant women in the non-APOs group participated in a longer treatment course. Course, time of the first antenatal care, gestation week at syphilis diagnosis, and gestation age at delivery in weeks were independent predictors of APOs, and they were used to establish the nomogram. The AUCs of the nomogram were 0.771 (95% CI, 0.708-0.834) and 0.733 (95% CI, 0.638-0.828) in the training and testing sets, respectively.Conclusions: Our study investigated the impact of various characteristics of syphilis pregnant women on pregnancy outcomes and established a prediction model of APOs in Suzhou. The incidence of APOs can be reduced by controlling for these risk factors.
Application of Two-Dimensional Speckle-Tracking Echocardiography in Radiotherapy-Related Cardiac Systolic Dysfunction and Analysis of Its Risk Factors: A Prospective Cohort Study
Authors: Liu Rong , Xu Li'ang , Wang Lan , Zhao Ziqi , Han Ruoling
Published: June 2022

Background: The cardiac toxicity of radiotherapy (RT) can affect cancer survival rates over the long term. The purpose of this study was to evaluate the value of two-dimensional speckle-tracking echocardiography (2D-STE) in early cancer therapy–related cardiac dysfunction (CTRCD), and to evaluate the risk factors of CTRCD and their effects on survival.Methods: We ultimately enrolled 40 patients who received RT for thoracic tumors. For each patient, 2D-STE was completed before, during, and after RT and in the follow up. We analyzed the sensitivity of 2D-STE in predicting CTRCD and the relationship between RT parameters and cardiac systolic function decline.Results: Left ventricle global longitudinal strain (LVGLS), LVGLS of the endocardium (LVGLS-Endo), LVGLS of the epicardium (LVGLS-Epi), and free-wall longitudinal strain (FWLS) decreased mid- and post-treatment compared with pre-treatment, whereas traditional parameters such as left ventricular ejection fraction (LVEF), cardiac Tei index (Tei), and peak systolic velocity of the free wall of the tricuspid annulus (s’) did not show any changes. The decreases in the LVGLS and LVGLS-Endo values between post- and pre-treatment and the ratios of the decreases to the baseline values were linearly correlated with mean heart dose (MHD) (all P values < 0.05). The decreases in the LVGLS-Epi values between post- and pre-treatment and the ratios of the decreases to the baseline values were linearly correlated with the percentage of heart volume exposed to 5 Gy or more (V5) (P values < 0.05). The decrease in FWLS and the ratio of the decrease to the baseline value were linearly related to MHD and patient age (all P values < 0.05). Endpoint events occurred more frequently in the right side of the heart than in the left side. Patients over 56.5 years of age had a greater probability of developing right-heart endpoint events. The same was true for patients with MHD over 2020 cGy in both the left and right sides of the heart.Conclusions: 2D-STE could detect damages to the heart earlier and more sensitively than conventional echocardiography. MHD is an important prognostic parameter for LV systolic function, and V5 may also be an important prognostic parameter. MHD and age are important prognostic parameters for right ventricle systolic function.
Examination of Key Genes in Angiogenesis of Breast and Prostate Cancers, in the Context of Different Cell Types
Authors: Jariani Abbas , Kakroodi Setareh Talebi , Arabfard Masoud , Rahimi Maryam
Published: June 2022

Background
The meaning of angiogenesis is the development of new blood vessels. Chemical signals start this process in the body. This will continue by migration, growth, and differentiation of endothelial cells, which line the inside wall of blood vessels. This process is vital for cancer cells.
Material and methods
Here, we investigated expression pattern of angiogenesis related genes in the context of previously published single-cell RNA-Seq data from prostate and breast cancer samples.
Results
Here we show how different modules of these angiogenesis related genes are over-expressed in different cell types, using protein-protein interaction network.
Conclusion
Our work demonstrates how different biological processes in distinct cell types that collaborate to the angiogenesis process, and can provide clues targeted inhibition of angiogenesis process.
Welfare implications of border carbon adjustments on the trade of harvested wood products
Authors: Liao Xinxin , Ning Zhuo
Published: June 2022

Background: Border Carbon Adjustments (BCAs) are designed to regulate carbon emissions and reduce carbon leakage. So far, BCAs are mainly applied for imported carbon-intensive products. On the other hand, harvested wood products (HWPs) are the extension of forest carbon stocks, whose changes affect a country’s carbon stock level. Nonetheless, the trade of HWPs also raises the problem of carbon leakage when their carbon stocks are exported, which can be partially solved by applying export BCAs.Result: By constructing a two-stage game, governments’ and forestry companies’ strategies under BCAs are analyzed. The government imposes BCAs on exports of HWPs when the carbon stock value exceeds a threshold. Moreover, the export BCAs on HWPs can effectively reduce the amount of HWPs exported. The results also show that BCAs diminish forestry exporters’ revenues and consumer surplus while having no significant detrimental impact on a country’s welfare.Conclusion: BCAs help include carbon stock values into HWPs’ prices and reduce carbon leakage, so they are beneficial for climate change. Thus, exporting countries can maintain their welfare by implementing BCAs, and the affected forestry companies can effectively cope with BCAs by improving the utilization efficiency of raw materials and their product quality.
Benzoic Acid Inclusion Effects on Health Status and Growth Performance of White Shrimp Juveniles Penaeus Vannamei
Authors: Loya-Rodríguez Mariany , Palacios-González Daniel Alberto , Lozano Rodolfo Olvera , Rodríguez Irma Eugenia Martínez , Puello-Cruz Ana Carmela
Published: June 2022

During the last decade, organic acids (OA) and their salts have been used as additives in aquafeed to increased nutritional values due their participation in some metabolic pathways and energy generation in organisms. Benzoic acid (BA) is one of the most used for its properties as a fungal growth inhibitor. It is used as a preserver in a wide variety of human consumption products included wine. Additionally, is also demonstrates health and growth benefits when its included in chickens, turkeys, cattle, and pig diets by modifying the energy metabolism and the microbiota and intestinal tract morphology. There is scarce information of BA inclusion in aquafeed and is non-existent in white shrimp, P. vannamei. This study evaluated the effects on growth, survival, feed conversion rate (FCR), energy content, and health status, through lipid quantification in hepatopancreas, histological analysis, and saline stress tests of white shrimp juveniles (Penaeus vannamei) by including BA at different concentrations (C0:0, C1:1.0, C2:1.5, and C3:2 g kg− 1) in a commercial feed. Increased BA inclusion presented significant differences (p ˂ 0.05) in the hepatosomatic index (Initial: 4.51 ± 0.65, C0: 4.01 ± 0.92, C1: 3.44 ± 1.68, C2: 2.37 ± 0.84, C3: 3.18 ± 1.60), hepatopancreas lipid content (Initial: 402.02 ± 48.76, C0: 293.48 ± 22.30, C1: 229.15 ± 11.46, C2: 136.69 ± 20.50, C3; 88.44 ± 6.19 mg g− 1) and histopathological damage in all BA concentrations. The lowest survival was 94.44% in C1. The FCR is within the ranges registered by the FAO except for that obtained in the C0. Calorimetric analysis and BA detection in muscle revealed no significant differences between concentrations. Due to the results obtained, the evaluated inclusions of BA in juvenile white shrimp (P. vannamei) diets are not recommended.
Understanding of Forces between Atomic Particles by Introduction of a New Particle Type in Space
Authors: Saha Ashim
Published: June 2022

In this paper it has been studied how does forces act between stable atomic particles. To do the findings it has been postulated that a tiny particle type is running throughout the space with some constant velocity. The particle of that type is so tiny that those particles almost don’t collide with each other and hence at any point in space if a solid atomic particle is being kept then the pressure on that atomic particle from all angles are same. However, if a second atomic particle is being brought closer to that former atomic particle, then shadows form on both atomic particles by each other atomic particles. Hence, pressure difference happens, and attraction force is being perceived. Also, it has been postulated that all atomic particles are made of this tiny particle type. As atomic particle spins it scatters those tiny particle and repulsive force is being perceived. In this paper this postulate has been verified mathematically and finally arrived at a formula of net force acting between two stable atomic particles. This mathematical model is successfully predicting change pattern of atomic radius with change in atomic numbers. Also, it is conforming that velocity of light is constant. This same model matches the Lennard-Jones potential function pattern between two atoms.
Case Report: Successful treatment with Dolutegravir containing antiretroviral therapy for acute on chronic liver failure by HBV in patients with HIV infection
Authors: Bi Mingyuan , Liu Yushen , Kang Wenzhen , Sun Yongtao , Kang Wen
Published: June 2022

Background: There’s no clear antiretroviral treatment for HIV/HBV co-infected patients with acute-on-chronic liver failure (ACLF) because of the vast majority of antiretroviral medications have hepatotoxicity. In this case report, we described two HIV/HBV co-infected ACLF patients treated with HAART regimen containing Dolutegravir (DTG) and successfully achieved symptom relief and viral suppression.Results: Two cases of HIV/HBV coinfection with ACLF who attempted to receive HAART containing DTG and were successfully treated without liver damage, immune reconstitution inflammatory syndrome (IRIS) or other complications occurred. Conclusions: It is proved that the application of DTG in HIV/HBV co-infected patients with ACLF has certain safety, which provides certain clinical basis for future prospective studies.
Multimodal personalized recommender algorithm based on knowledge graph
Authors: Walinder Lenart , Price Maynard , Lim Breda , Smith Burnet
Published: June 2022

An effective recommendation system can not only increase the stickiness of platform users, but also the traffic brought by user conversion and retention can significantly increase the revenue of the video platform. Current recommendation systems enable recommendations between text, images, audio, and video, pre-tagging different media files to generate different tags, and then searching for user-requested content through search engines. However, with the development of video platforms, users' personalized needs are getting stronger and more complex recommendation scenarios, and the accuracy of video recommendations is becoming more and more demanding. Compared with the structured data in traditional databases, multimedia data is characterized by large dimensionality, rich data content, and the large storage space required for the data. Multimedia data contains information of multiple modalities, i.e., text, image, and audio. Although there are some works that analyze the content of videos, these works only consider the unimodal data of videos. In this paper, we will explore how to use multimodal techniques and knowledge graphs to enhance user representations, and try to extend the idea of multimodal feature learning to existing knowledge graphs recommendation algorithms.
Complete Chloroplast Genome Sequence from Rosa lucieae and Its Characteristics
Authors: Shen Weixiang , Dong Zhanghong , Zhao Wenzhi , Ma Luyao , Wang Fei , Li Weiying , Xin Peiyao
Published: June 2022

Rosa lucieae Franch. & Rochebr. ex Crép. is one of the famous wild ancestors of cultivated roses and plays a very important role in horticultural research, but there is still a lack of research on the R. lucieae chloroplast genome. In this study, we used the Illumina MiSeq sequencing platform for sequencing, assembly and annotation to obtain the sequence information for the R. lucieae chloroplast genome and compared genomics, selection 1 stress analysis, and phylogenetic analysis with 12 other chloroplast genomes of Rosa. The R. lucieae cpDNA sequence has a total length of 156,504 bp and 130 genes are annotated. The length of all 13 studied chloroplast genomes is 156,333~157,385 bp. Their gene content, gene sequence, GC content and IR boundary structure were highly similar. Five kinds of large repeats were detected that numbered 100~116, and SSR sequences ranged from 78 to 90 bp. Four highly differentiated regions were identified, which can be used as potential genetic markers for Rosa. Selection stress analysis showed that there was significant positive selection among the 18 genes. The phylogenetic analysis of R. lucieae and R. cymose, R. maximowicziana, R. multiflora, and R. pricei showed the closest relationship. Overall, our results provide a more comprehensive understanding of the systematic genomics and comparative genomics of Rosa.
Pain adverse events, Bell’s palsy, and Guillain-Barré syndrome Following Vaccination
Authors: Ricke Darrell O.
Published: June 2022

Some individuals (vaccinees) experience pain related adverse events following vaccinations. The majority of vaccination reactogenicity adverse events resolve within days. Rare adverse events like Bell’s palsy and Guillain-Barré syndrome (GBS) have been associated with some vaccines. Herein, multiple working hypotheses are examined in the context of datamining results of the Vaccine Adverse Event System (VAERS) database. Observed onset occurrences of examined pain associated adverse events are consistent with likely etiology relationship with innate immune responses to vaccinations for multiple vaccines including SARS-CoV-2 COVID-19, influenza, and additional vaccines. Innate immune responses may be contributing to the initial etiology of Bell’s palsy and GBS post SARS-CoV-2 mRNA and adenoviral vaccinations.
Allometric relations between DBH and sapwood area for predicting stand transpiration: Lessons learned from the Quercus genus
Authors: Schoppach Rémy , Chun Kwok Pan , Klaus Julian
Published: June 2022

Catchment-scale transpiration is commonly determined by the use of sap-flow sensors, and its quantification, which is critical for water and forest management, relies crucially on the total catchment’s sapwood area (As). Species-specific allometric relationships between the trees As and the trees diameter at breast height (DBH) are widely used for determining stand or catchment As. However, substantial differences between studies challenged the robustness of these relationships between sites displaying various topographical and environmental characteristics. In this study, we aim at comparing these relationships between species of the Quercus genus from sites in different parts of the world, and testing the role of topographical factors on As-DBH relationship in Quercus petraea. Using 145 trees sampled within a 0.455 km² catchment, we showed that topography (slope, flow accumulation, aspect, curvature, topographic wetness index) does not modulate the As-DBH relationship in Quercus petraea, within our catchment. We compared our curve parameters with the ones from 17 studies on oak trees and found that the As-DBH relationship is not only species-specific, but depends on the site’s conditions, and likely the stand density, the total radiation and the evaporative demand. In the light of these results, we recommend to build site- and species-specific As-DBH relationship for determining stand transpiration, using a minimum of nine, randomly sampled trees, and different methods and azimuthal directions for determining sapwood depth.
How Does the Codified Knowledge Relatedness Influence Foreign Intelligence Import in Emerging Countries: Evidence from Chinese PCT Activities
Authors: Zhou Hao , Lin Jie
Published: June 2022

With the accelerated evolution of the global innovation pattern, the micro-foundation of the participation of emerging countries’ innovation subjects in the global ‘war for talent’ has gradually become the focus of relevant studies. Based on the perspective of citation coupling, this study uses the bibliographic-patent-coupling (BPC) indicators between 214 innovation subjects owned by 96 popular innovative organisations in China and 431 overseas regions with patent cooperation treaty (PCT) activity records to describe the bilateral codified knowledge (CK) relatedness and examine its impact on the allocation of overseas PCT inventors by Chinese innovation subjects. The results show that the BPC relationship significantly increases the scale of Chinese innovation subjects’ intelligence import from overseas regions, especially the regions with rapid innovation. The effect of the BPC relationship on increasing the foreign intelligence import scale of innovation subjects is positively affected by the quality of the patents jointly cited by both parties. The study further finds that the heterogeneity of innovation subjects can affect the effect of foreign intelligence import on BPC strength. Finally, the tacit knowledge (TK) relatedness at the geographic and organisational levels can promote the import of foreign intelligence of innovation subjects and have a coordinated effect on the BPC relationship. This coordinated effect mainly exists in high-quality innovation activities driven by enterprise innovation subjects.
Quality of Life in patients with Filum Disease and Neuro-cranio-vertebral Syndrome with Arnold-Chiari Syndrome Type I, Idiopathic Syringomyelia, Idiopathic Scoliosis
Authors: Royo-Salvador Miguel B. , Luè Gioia
Published: June 2022

Filum disease and Neuro-cranio-vertebral syndrome are two pathological concepts that comprise various diseases. Our objectives are to describe their neuro-psychological alterations, and to conduct a descriptive analysis of how these diagnoses can influence Quality of Life. We conducted a retrospective, descriptive study of the clinical anamneses of patients diagnosed with Filum disease from a sample of 372 randomly selected patients in relation to their Quality of Life. We also analysed the self-reported psychological-emotional health in 34 other patients. Mood alterations and cognitive and sexual dysfunction may also be affected in these pathologies. Filum disease deteriorates Quality of Life and affects perceived Quality of Life. Many patients report how the gradual worsening of symptoms affects the self-assessment and self-perception of their own physical and psychological health, influencing their expectations in various areas of life. Quality of Life can be affected by limited physical condition, headaches, pain, instability, lack of sensitivity or strength, or paresis. The consequences that Filum disease can have on environmental and social context correspond to a further decrease in Quality of Life. For the diagnosis, prognosis, treatment, and post-operative evaluation, it is essential to consider everything reported in the initial anamnesis.
PENGEMBANGAN SIKAP RELIGIUS PADA ANGGOTA RESIMEN MAHASISWA (MENWA) MAHAPURA IAIN PONTIANAK
Authors: Sukino Sukino , Handini Agus , Wara ‎ Agnia
Published: June 2022

This study discusses efforts to develop religious attitudes among students which are always important to be carried out by institutions through Student activity units independently so that their potential as leaders is honed based on moderate Islamic religious values. The purpose of this study was to obtain information about: 1) program activities designed by the commander and staff in shaping the religious character of the members of the MENWA. 2) challenges faced in implementing program activities in shaping the religious character of members of the Mahapura student regiment. The research approach was qualitative, the data source of this study consisted of primary data sources of menwa and secondary leaders (Menwa members), Mahapura IAIN Pontianak. This study found a program of religious development activities namely, Yasisnan and Tahlilan, Khataman al-Quran, and social care: Menwa Sharing through fundraising, the two challenges faced in developing religious attitudes are forgiving excessive self-weakness, lack of interest in religion, and lack of interest in religion. Sense of responsibility due to feeling tired after participating in activities on campus. This finding becomes a new model for the development of religious attitudes among intra-campus organizations in preparing a generation that is physically strong and has a strong faith
KOMPARASI PERKEMBANGAN POTENSI ANAK USIA DINI MENURUT ISLAM DENGAN TEORI KOHLBERG
Authors: Bahri Saiful
Published: June 2022

Abstrak: Kohlberg sangat memperdulikan perkembangan manusia, sehingga dia mengemukakan tiga tahapan perkembangan potensi manusia, sedangkan Islam sebagai agama yang rahmatan lil ‘alamiin sangat memperdulikan perkembangan manusia, sehingga mengemukakan konsep tentang perkembangan tersebut dalam hadits dan al-Qur’an. Persamaan antara kedua teori tersebut adalah sama-sama mengungkapkan tahapan-tahapan perkembangan anak dan perkembangan potensi anak. Kemudian juga mengungkapkan tahapan pendidikan yang harus dilaksanakan kepada anak supaya anak dapat berkembang sesuai dengan bakat alaminya. Perbedaannya mulai dari perbedaan epistemologi dan juga perbedaan pengembangan konsep fitrah.

 

Kata kunci: Potensi Anak Usia Dini, Teori Kohlberg

Abstract: Kohlberg really cares about human development, so he put forward three stages of human potential development, while Islam as a religion which is rahmatan lil 'alamin really cares about human development, so he put forward the concept of this development in the hadith and the Qur'an. The similarities between the two theories are that they both reveal the stages of child development and the development of children's potential. Then also reveal the stages of education that must be carried out to children so that children can develop according to their natural talents. The differences start from differences in epistemology and also differences in the development of the concept of fitrah.

 

Keywords: Early Childhood Potential, Kohlberg's Theory
PEMIKIRAN MUHAMMAD IQBAL TENTANG PENDIDIKAN KARAKTER DAN RELEVANSINYA DENGAN ERA DISRUPSI
Authors: Masluhah Masluhah , Afifah Kiki Rizkiatul , Salik Mohamad
Published: June 2022

Abstract: Muhammad Iqbal is a Philosopher and education’s figure. His saveral ideas are about character education and education of creativity. Disruption era brings a complex problem, especially in moral and character development. The deterioration of student’s moral value will be a trigger to make attitude and behavior that doesn’t suit with spiritual value or the oble values of Indonesian nation. Therefore, character development in disruption era be a very important discussion. This research aims to analyze Muhammad Iqbal’s views of character education that relevance to disruption era. The research’s method is library research with data collection techniques from any references such as books, journals, newspaper, and others articles. This research used descriptive analysis technique. The results is according to Muhammad Iqbal’s thoughts that character education is an effort to prevent the moral crisis phenomenon on students that relevant at disruption era. Impementation of the character education is with modelling of positive character and behavior, development self-awareness about human essence as insan kamil, and developement the tolerance.
Corporate Social Responsibility, Sustainability Governance and Sustainable Performance: A Preliminary Insight
Authors: Mustafa Rehman Khan  , Haseeb ur Rehman Khan  , Arsalan Mujahid Ghouri
Published: June 2022

This conceptual paper aims to investigate corporate social responsibility (CSR) practises in the tourism sector. Drawing on the existing literature this study conceptualises the linkage between CSR, sustainability governance, and sustainable performance. Moreover, this study conceptualises three sub-dimensions of CSR. The integration of CSR in the tourism sector is significant and novel. An analytical review is conducted to present conceptual linkage and research implications. The finding implies that CSR positively influences the sustainable performance of organisations and sustainable governance plays a mediating role between relationships. This study provides important implications that help tourism industry practitioners to realise the significance of reducing environmental and social problems, which cause by tourism activities. Further, this study obtains support from institutional theory to explain the relationships of governance mechanism and CSR that leads to economic performance as well as create value for nature and the local community. Additionally, the future direction of research is provided that highlights some important avenues in the sustainability field.
Influence of Front-Desk Staff Service Quality on Students’ Affective Commitment, Trust, and Word-of-Mouth in Higher Education
Authors: Muhammad Asif Qureshi  , Syed Ali Raza  , Ishtiaq Ahmed Kolachi  , Areeba Sarwar  , Komal Akram Khan
Published: June 2022

Private universities are growing in the present era. The enrollment ratio is also getting high, and universities are putting efforts to attract more students. Hence, it is essential to provide students with the best quality services as it spreads positive word-of-mouth. Therefore, the present article is designed to study the impact of front-desk staff service quality on word-of-mouth through the mediating effect of students’ affective commitment and students’ trust. An online questionnaire survey was conducted in Karachi, Pakistan. This study used the partial least square method to run structural equation modeling analysis. The findings revealed that all paths show a positive and significant relationship except front-desk staff service quality and word-of-mouth. Moreover, students’ affective commitment and trust mediate the relationship between front-desk staff service quality and word-of-mouth. Results also illustrate that gender exerts a significant moderating role on front-desk staff service quality, students’ affective commitment, and word-of-mouth. The study provides practical implications for policymakers, private university  management, and educational institutions. Firstly, it is crucial to provide effective communication training to the front-desk staff to learn the basic etiquette of greetings and humbleness. Secondly, there must be experienced personnel who can assist students promptly.
Applicability of Maqasid Al-Shariah Towards Home Financing by Islamic Banks among University Staff in Malaysia
Authors: Hanudin Amin
Published: June 2022

Despite their significant growth, Islamic banks only consider about avoiding riba, gharar, and maysir at the expense of maqasid al-Shariah. The banks are somewhat converged with their conventional peers. Consumers believed that the banks imitate their peers pertinent to the pricing calculations and product lines. Without effective measure, consumers may discern Islamic banks undermine their maqasid objective and continued critics of mimicking their peers are prolonged. Against this backdrop, this study examines consumer preference using a proposed index known as the Maqasid Consumer Preference Index (MCPi). Drawing upon the MCPi, the present study examines consumer preference for six Islamic banks operated in Malaysia to which Islamic home financing products are presently made available. Our data were drawn from valid 450 usable questionnaires. The results obtained report that six Islamic banks relatively have a moderate index. Of these, Bank Islam Malaysia Berhad (BIMB) is ranked first, followed by Maybank Islamic, CIMB Islamic whilst Kuwait Finance House is ranked last. This work examines a new approach to measure consumer preference using the MCPi. Our contributions are confined to these particular factors – educating customer, establishing justice, and promoting welfare in the context of Islamic home financing in Malaysia. Future works may provide a different perspective on these interrogations by considering new dimensions to extend the findings. Despite this concern, the results obtained offer improved insights for bank managers to manage Islamic home financing products effectively.
A Hybrid Fuzzy Approach to Success in E-Commerce Adoption in Iranian Manufacturing SMEs
Authors: Amir Hakaki  , Mohsen Shafiei Nikabadi
Published: June 2022

E-commerce adoption is one of the most controversial subjects among small and medium enterprises (SME)s in Iran. The present study is conducted with the aim of identifying the most important factors in e-commerce adoption – reviewing the causal relationships and clustering them. To identify the most important factors, the data is collected by questionnaires filled by 95 experts who were chosen as researchers’ judgment. Examining the causal relationships among the studied factors and clustering is done by fuzzy decision making trial and evaluation laboratory (DEMATEL) and interpretive structural modelling (ISM) techniques respectively. Data is collected from 12 experts and analysed by MATLAB and EXCEL software. According to the results, government support as one of the causal factors among critical factors effecting on e-commerce adoption is the highest influential factor, along with cost of public’s training. Both factors are put into the first cluster. Moreover, organisational flexibility plays an intermediate role between the first and the third cluster.
Atomistic insight into the ferroelastic post-stishovite transition by high-pressure single-crystal X-ray diffraction
Authors: Zhang Yanyao , Chariton Stella , He Jiaming , Fu Suyu , Xu Fang , Prakapenka Vitali B. , Lin Jung-Fu
Published: June 2022

The post-stishovite transition is a classic pseudo-proper typed ferroelastic transition with a symmetry-breaking spontaneous strain. This transition has been studied using high-pressure spontaneous strains, optic modes, and elastic moduli (Cij) based on the Landau modeling, but its atomistic information and structural distortion remain poorly understood. Here we have conducted synchrotron single-crystal X-ray diffraction measurements on stishovite crystals up to 75.3 GPa in a diamond-anvil cell. Analysis of the data reveals atomic positions, bond lengths, bond angles, and variations of SiO6 octahedra across the transition at high pressure. Our results show that the O coordinates split at ~51.4 GPa, where the apical and equatorial Si-O bond lengths cross over, the SiO6 octahedral distortion vanishes, and the SiO6 octahedra start to rotate about the c axis. Moreover, distortion mode analysis shows that an in-plane stretching distortion (GM1+ mode) occurs in the stishovite structure at high pressure while a rotational distortion (GM2+ mode) becomes dominant in the post-stishovite structure. These results are used to correlate with elastic moduli and Landau parameters (symmetry-breaking strain e1–e2 and order parameter Q) to provide atomistic insight into the ferroelastic transition. When the bond lengths of two Si-O bonds are equal due to the contribution from the GM1+ stretching mode, C11 converges with C12, and the shear wave VS1[110] polarizing along [110] and propagating along [110] vanishes. Values of e1–e2 and Q are proportional to the SiO6 rotation angle from the occurrence of the GM1+ rotational mode in the post-stishovite structure. Our results on the pseudo-proper type transition are also compared with that for the proper type in albite and improper type in CaSiO3 perovskite. The symmetry-breaking strain, in all these types of transitions, arises as the primary effect from the structural angle (such as SiO6 rotation or lattice constant angle) and its relevant distortion mode in the low-symmetry ferroelastic phase.
AVALIAÇÃO RÁPIDA DA QUALIDADE DO ÓLEO VEGETAL ISOLANTE DE TRANSFORMADOR POR ESPECTROSCOPIA FTIR E QUIMIOMETRIA
Authors: Barbosa Nathália , Santos Larissa , Seguchi Lucas , Silva Beatriz , Carvalho Thaís , Wanderley Estácio , Gimenes Rossano , Soares Melina , Araujo Ana , Silva Flávio , Almeida Mariana , Silva Milady
Published: June 2022

RAPID ASSESSMENT OF TRANSFORMER INSULATING VEGETABLE OIL QUALITY USING FTIR SPECTROSCOPY AND CHEMOMETRICS. Although analytical techniques to assess the degradation of transformer insulation systems are well established, it is essential to develop fast and effective methodologies for monitoring the quality of power transformer insulating fluid. The objective of this work was to develop a fast, simple, and environmentally friendly method to evaluate and monitor the quality of insulating vegetable oil (IVO) from transformers, using multivariate control chart and infrared spectroscopy (FTIR). For the development of the method, IVO samples were subjected to electrical and thermal stress, as well as to contact with insulating paper and copper, to simulate the internal environment of a transformer before and after energizing. Control chart based on principal component analysis was developed to monitor insulating vegetable oil quality. It was possible to identify oil samples with oxidation levels that were outside the acceptable quality standards for insulating fluid in transformers. The results demonstrated the potential of FTIR spectroscopy and control charts as fast and simple tools for monitoring the quality of insulating fluids, enabling the identification of oil samples that fail to comply with regulation standards for insulating fluids, assisting in the implementation of maintenance programs for power transformers.
Utilization of low-potential secondary energy resources at oil pumping station
Authors: Dashkin Ravil , Muftakhov Evgeny
Published: June 2022

The article considers the sources of low-potential heat at oil pumping station, estimates the amount of heat of technological processes that is irretrievably lost in the environment from the oil ACD, cooling systems of electric motors and wastewater treatment plants, and also presents possible ways of utilization and useful use of this heat using heat pumps.
Detailed experimental and numerical analysis of hydrodynamics in the outflow measurement channel of a sewage treatment plant
Authors: Ragessi I. Matias , García Carlos Marcelo , Damian Santiago Marquez , Tarrab Leticia , Patalano Antoine , Rodriguez Andres
Published: June 2022

The ‘Bajo Grande’ Wastewater Treatment Plant has a design capacity of 2.78 m3/s, and discharges into the Suquia River (Córdoba, Argentina). The river has an average flow rate of 10 m3/s, with lower values during the summer. Currently, the treatment plant does not have an accurate discharge-measurement system prior to the discharge into the river, which makes it difficult to evaluate the dosing of the disinfection treatment. The outflow rate is measured in a straight flume. However, at the inlet section of the flume, a 180° sharp bend induces a complex turbulent flow with instabilities and low-frequency velocity fluctuations which are not appropriate for flow quantification. In this type of flow, most of the in situ flow discharge-measurement systems have great uncertainty. Therefore, in situ flow measurements with an Acoustic Doppler Current Profiler, Large-Scale Particle-Tracking Velocimetry techniques and a prototype-scale Detached Eddy Simulation model were combined to obtain a detailed characterization of the turbulent flow. The results provide flow rates, fields of mean flow velocity, temporal evolution, and characteristic parameters of the turbulence. This allowed a better understanding of the effects of turbulence and flow instabilities. The results provide a basis to validate numerical models used in the hydraulics design of contact chambers to improve the disinfection process.
Crystal-State Structure of the C-Terminal Pentapeptide of the Antibiotic Efrapeptin C
Authors: Benedetti Ettore , Iacovino Rosa , Saviano Michele , Kamphuis Johan , Crisma Marco , Formaggio Fernando , Moretto Vittorio , Toniolo Claudio
Published: June 2022

An X-ray diffraction analysis of the C-terrninal, fully block...d pentapeptide segment of the antibiotic efrapeptin C Z-L-Pip-Aib-Gly-L-Leu-Aib-NHMe monohydrate showed that its secondary structure is characterized by three non-helical -bend conformations located at the -L-Pip-Aib-, -Aib-Gly-, and -L-Leu-Aib- sequences, respectively .
Crystallization and Preliminary Characterization of Shigella Boydii DGTP­ Triphosphohydrolase
Authors: Quirk Stephen
Published: June 2022

The enzyme deoxyguanosine triphosphatetriphosphohydrolase from Shigella boydii has been crystallized by the vapor diffusion method using2-methyl-2,4-pentanediol and calcium chloride in sodium acetate buffer
(pH4.5). The monoclinic crystals belong to space group P2t andhave unit cell dimensions a= 157.2 A, b =
74.8 A, c = 93.1 A, and β = 91.6°. Thecrystals diffract to 3.0• A resolution, and there is one 237.6 .kDa
enzymetetramer per asymmetric unit. The crystals have a solvent content of 47%.
Production and Functional Characterization of a Novel Mannanase from
Alteromonadaceae Bacterium Bs31
Authors: Ding Rui , Xie Huifang , Han Zhenggang , Yang Jiangke
Published: June 2022

Background:

Mannans are the main components of hemicellulose in nature and serve as
the major storage polysaccharide in legume seeds. To mine new mannanase genes and identify their
functional characteristics are an important basis for mannan biotechnological applications.

Objective:

In this study, a putative mannanase gene (ManBs31) from the genome of the marine
bacterium Alteromonadaceae Bs31 was characterized.

Methods:

Amino acid sequence analysis and protein structural modeling were used to reveal the
molecular features of ManBs31. The catalytic domain of ManBs31 was recombinantly produced
using Escherichia coli and Pichia pastoris expression systems. The biochemical properties of the
enzymes were determined by reducing sugar assay and thin-layer chromatography.

Results:

Sequence analysis revealed that ManBs31 was a multidomain protein, consisting of a
catalytic domain belonging to glycoside hydrolase family 5 (GH5) and two cellulose-binding
domains. Recombinant ManBs31-GH5 exhibited the maximum hydrolytic performance at 70 ºC and
pH 6. It showed the best hydrolysis capacity toward konjac glucomannan (specific enzyme activity
up to 1070.84 U/mg) and poor hydrolysis ability toward galactomannan with high side-chain
modifications (with a specific activity of 344.97 U/mg and 93.84 U/mg to locust bean gum and
ivory nut mannan, respectively). The hydrolysis products of ManBs31-GH5 were mannooligosaccharides,
and no monosaccharide was generated. Structural analysis suggested that
ManBs31-GH5 had a noncanonical +2 subsite compared with other GH5 mannanases.

Conclusion:

ManBs31 was a novel thermophilic endo-mannanase and it provided a new alternative
for the biodegradation of mannans, especially for preparation of probiotic mannooligosaccharides.