bluuebunny/crossref_metadata_2025 huggingface dataset:
MƏTNLƏRDƏN TERMİNLƏRİN AVTOMATİK ÇIXARILMASI METODLARININ ARAŞDIRILMASI VƏ MÜQAYİSƏLİ ANALİZİ
Authors:   AMEA İnformasiya Texnologiyaları İnstitutu, Qurbanova Əfruz
Published: February 2021

Məqalədə mətnlərdən terminlərin avtomatik çıxarılmasının beş metodu tədqiq olunmuş və onların müqayisəli analizi verilmişdir. Mətnlərdən terminlərin çıxarılmasının ümumi məqsədi xüsusi sahənin əsas lüğətinin təyin edilməsidir. Terminlərin ənənəvi olaraq əl ilə çıxarılmasından fərqli olaraq avtomatik çıxarılması vaxt aparan bu işi sadələşdirmək üçün kompüterləşdirilmiş bir vasitədir və termin-namizədlərin əvvəlcədən müəyyənləşdirilməsinin avtomatlaşdırılmasına yönəlib. Hazırkı dövrdə bir çox sahələrdə (leksikoqrafiya, terminşünaslıq, informasiya axtarışı və s.) emal olunmalı informasiyanın həcminin artım dinamikası termin və açar sözlərin avtomatik seçilməsi məsələsini xüsusilə aktual edir. Təbii dilin emalı sahəsində qurulan qaydaları təqdim edən mətnlərdən terminlərin avtomatik çıxarılması üçün bir çox fərqli yanaşma və sistem işlənmişdir. Mətnlərdən terminlərin avtomatik çıxarılmasının müxtəlif altməsələləri – korpus kolleksiyası, vahid birliklər, termin və variantların müəyyən olunması və keyfiyyətin qiymətləndirilməsi qaydası təqdim olunmuşdur. Müəyyən predmet sahəsi üçün mətnlərdən terminlərin avtomatik çıxarılmasına tətbiqi yanaşma verilmişdir. "İnformasiya texnologiyaları problemləri" və "İnformasiya cəmiyyəti problemləri" jurnallarının məqalələrinin korpusu üzərində eksperiment aparılmışdır. Ekspert və formal qiymətləndirmə metodikası təklif olunmuş, terminlərin avtomatik çıxarılması metodlarının müqayisəli qiymətləndirilməsinin nəticələri verilmişdir.
INDUSTRY 4.0 ŞƏRAİTİNDƏ ƏMƏK BAZARININ İNTELLEKTUAL İDARƏ OLUNMASINA METODOLOJİ YANAŞMA
Authors:   AMEA İnformasiya Texnologiyaları İnstitutu, Məmmədova Məsumə , Cəbrayılova Zərifə ,   AMEA İnformasiya Texnologiyaları İnstitutu
Published: February 2021

Məqalədə dinamiki dəyişən əmək bazarında tələb və təklifin intellektual idarə olunması üçün metodoloji yanaşma işlənilmişdir. İndusrty 4.0 tətbiqi ilə peşələrin strukturunun dəyişməsi, bir sıra peşə və ixtisasların “köhnəlməsi” və sıradan çıxması, yenilərinin meydana gəlməsi əmək bazarının idarə olunmasında prioritetli peşə qruplarının və ixtisasların təyin edilməsini şərtləndirir. Yeni peşə və ixtisaslar, oz növbəsində, yeni bilik, vərdiş və bacarıqların mənimsənilməsini tələb edir. Bu, təhsilin strukturu ilə əmək bazarında lazımi profillər üzrə mütəxəssislərə olan tələb arasında uyğunsuzluq yaradır, müxtəlif profillər üzrə mütəxəssislərə olan tələb və təklifin qiymətləndirilməsi metodlarının işlənilməsini aktuallaşdırır. Əmək bazarında peşə qruplarının və ixtisasların prioritetliyinin təyini üçün qeyri-səlis çoxkriteriyalı modelə istinad etməklə çoxkriteriyalı qərar qəbulu metodları işlənilmiş, bu prioritetlər üzrə tələb və təklifin qeyri-səlis situasiya modelləri əsasında onların uyğunlaşdırılması qeyri-səlis obrazların tanınması məsələsinə gətirilmişdir. Tələb və təklifin mümkün qarşılıqlı əlaqə ssenariləri üzrə onların uyğunlaşdırılması qərarlarının qəbulunun dəstəklənməsi metodları və alqoritmləri işlənilmişdir. Təklif edilən yanaşma innovasiyalı iqtisadiyyatın inkişafını, işəgötürənlərin yeni peşə, ixtisas və kompetensiyalara tələblərini nəzərə almaqla əmək bazarında real vəziyyəti qiymətləndirməyə imkan verən, prioritetli peşə qrupları və ixtisaslar üzrə tələb və təklifin uyğunluğu ilə bağlı qərarların qəbulunu dəstəkləyən sistemin riyazi-metodoloji əsasını təşkil edir.
KLASTERLƏŞDİRMƏ METODLARININ TƏTBİQİ İLƏ SOSİAL ŞƏBƏKƏLƏRDƏ SAXTA PROFİLLƏRİN AŞKARLANMASI
Authors:   AMEA İnformasiya Texnologiyaları İnstitutu, Əhmədova Xəyalə
Published: February 2021

Sosial şəbəkələr istifadəçiləri üçün yeni dostlar tapmaq, xəbər oxumaq, faydalı məlumatlar əldə etmək, əyləncə kimi bir sıra imkanlar təklif etdiyindən milyonlarla aktiv istifadəçisi vardır. Sosial şəbəkələrin milyonlarla aktiv istifadəçiyə malik olması insanların gizli şəkildə idarə edilməsi (manipulyasiya), müxtəlif növ çağırışlar, insan və ya təşkilatların nüfuzdan salınması kimi zərərli məqsədlərin icrası üçün şərait yaradır. Bu zaman troll profillər, sibil hesablar, kuklalar, bot hesablar və s. kimi qrup şəklində fəaliyyət göstərən saxta profillər geniş şəkildə istifadə edilir. Klassifikasiya alqoritmlərinin tətbiqi ilə saxta profillərin aşkarlanması zamanı verilənlərin sinif nişanlarına (ing. label) malik olmaları, çox sayda profilin tək-tək təsnif edilməsi zamanı sərf edilən vaxt və s. kimi problemlər ortaya çıxır. Bu məqalədə sosial şəbəkələrdə saxta profillərin qruplaşdırılması üçün k-means, Gaussian Mixture, aqlomerativ klasterləşdirmə, spektral klasterləşdirmə alqoritmləri istifadə edilmişdir. Klasterizasiya alqoritmləri saxta profillərin aşkarlanmasında klassifikasiya metodlarına nisbətən pis nəticə göstərdiyindən bu məqalədə saxta profillərin aşkarlanması üçün tətbiq edilmiş klasterizasiya metodlarının hansı verilənlər üzrə daha yaxşı nəticə verməsi məsələsinə baxılmışdır. Alqoritmlərin tətbiqi zamanı profiləsaslı verilənləri ehtiva edən əlyetər bazalardan istifadə edilmişdir. Klasterizasiya metodlarının nizamlanmış rand indeksi, homogenlik, dolğunluq və s. kimi qiymətləndirmə metrikalarının tətbiqi ilə performansının qiymətləndirilməsi zamanı əldə edilmiş nəticələrə əsasən, aqlomerativ klasterləşdirmə alqoritmi digər tətbiq edilmiş klasterizasiya alqoritmlərinə nisbətən daha yaxşı nəticə göstərmişdir.
XIV Congresso de Iniciação Cientifica da Universidade de Araraquara
Authors: Carvalho De Lorenzo Helena
Published: February 2021

Os trabalhos que compõem o presente volume da Revista Brasileira Multidisciplinar ReBRAm são versões expandidas de dez resumos, selecionados dentre os quase 500 trabalhos apresentados no XIV Congresso de Iniciação Cientifica da Uniara, realizado no período de 04 a 08 de novembro de 2019, na Universidade de Araraquara. Este evento, que se iniciou em 2006, como um pequeno congresso de caráter local, vem gradativamente se ampliando e ganhando a participação de estudantes e pesquisadores de outras instituições de ensino da região e acontece graças aos esforços de um grupo de professores que, em anos consecutivos, veem se empenhando para a realização do mesmo. Também tem sido o resultado de trabalho de nossa comunidade de docentes e pesquisadores, e da sua crença de que a iniciação cientifica é uma ferramenta fundamental para a formação profissional de nossos alunos.

É, evidentemente, impossível socializar com os leitores o calor gratificante de um congresso de iniciação cientifica, o interesse e alegria dos jovens e o intercambio fecundo entre estudantes e docentes de diversos cursos de graduação. Pensamos, porém, que é relevante partilhar com o público, em especial, leitores desta revista multidisciplinar, os artigos que compõem este volume, como prestação de contas de nosso trabalho, e como contribuição ao debate e à realização de novas pesquisas....
Metode Deteksi Intrusi Menggunakan Algoritme Extreme Learning Machine dengan Correlation-based Feature Selection
Authors: Sulandri Sulandri , Basuki Achmad , Bachtiar Fitra Abdurrachman
Published: February 2021

Deteksi intrusi pada jaringan komputer merupakan kegiatan yang sangat penting dilakukan untuk menjaga keamanan data dan informasi. Deteksi intrusi merupakan proses monitor traffic pada sebuah jaringan untuk mendeteksi adanya pola data yang dianggap mencurigakan, yang memungkinkan terjadinya serangan jaringan. Penelitian ini melakukan analisis pada traffic jaringan untuk mengetahui apakah paket tersebut mengandung intrusi atau merupakan paket normal. Data traffic yang digunakan untuk deteksi intrusi pada penelitian ini diambil dari dataset KDD Cup. Metode yang digunakan untuk melakukan deteksi intrusi dengan cara klasifikasi yaitu dengan menggunakan metode Extreme Learning Machine (ELM). Namun, dengan menggunakan metode ELM saja tidak mampu untuk menghasilkan akurasi yang baik maka, pada metode ELM perlu ditambahkan metode seleksi fitur Correlation-Based Feature Selection (CFS) untuk meningkatkan hasil akurasi dan waktu komputasi. Hasil penelitian yang dilakukan dengan menggunakan metode ELM menunjukkan tingkat akurasi mencapai 81,97% dengan waktu komputasi 3,39 detik. Setelah ditambahkan metode seleksi fitur CFS pada ELM tingkat akurasi meningkat secara signifikan menjadi 98,00% dengan waktu komputasi 2,32 detik.

 

Abstract

Intrusion detection of computer networks is a very important activity carried out to maintain data and information security. Intrusion detection is the process of monitoring traffic on a network to detect any data patterns that are considered suspicious, which allows network attacks. This research analyzes the network traffic to find out whether the packet contains intrusion or is a normal packet. Traffic data used for intrusion detection in this study were taken from the KDD Cup dataset. The method used to do intrusion detection by classification is using the Extreme Learning Machine (ELM) method. However, using the ELM method alone is not able to produce good accuracy, so the ELM method needs to be added to the Correlation-Based Feature Selection (CFS) feature selection method to improve the accuracy and computational time. The results of the research conducted using the ELM method showed an accuracy rate of 81.97% with a computation time of 3.39 seconds. After adding the CFS feature selection method to ELM the accuracy level increased significantly to 98.00% with a computing time of 2.32 seconds.
Desain Arsitektur IoT untuk Budidaya Gurami
Authors: Sudianto Yupit
Published: February 2021

Sektor perikanan di Indonesia memiliki potensi bagus untuk dikembangkan. Dengan pengelolaan yang baik, sektor ini dapat memberikan kontribusi bagi ketahanan pangan nasional dan meningkatkan kesejahteraan bagi masyarakat Indonesia. Salah satu sektor perikanan yang menarik untuk dibudidayakan adalah ikan gurami. Gurami banyak diminati oleh masyarakat dan memiliki harga jual yang stabil. Namun, kendala dalam budidaya gurami adalah pertumbuhan yang lambat, biaya pakan yang tinggi, dan tingkat kelangsungan hidup yang rendah. Seiring dengan perkembangan teknologi internet of things (IoT) dewasa ini, tentunya teknologi ini dapat memberikan solusi bagi pembudidaya gurami untuk mengatasi kendala tersebut. Oleh karena itu, pada penelitian ini diusulkan arsitektur IoT untuk budidaya gurami. Arsitektur IoT yang diusulkan dalam penelitian ini memiliki enam desain yang terdiri dari domain model, business process hierarchy, IoT layer, deployment, information, dan interoperability endpoint. Dengan adanya arsitektur IoT ini diharapkan sistem IoT yang dibangun sesuai dengan kebutuhan pembudidaya gurami serta memudahkan developers untuk membangun dan mengembangkan sistem tersebut.

 

Abstract

The fisheries sector in Indonesia has great potential to be developed. With good management, this sector can contribute to national food security and improve welfare for the people of Indonesia. One of the interesting fisheries sector to be cultivated is gurami. Gurami is much in demand by the public and has a stable selling price. However, growth in gouramy cultivation is slow growth, high food costs, and low survival rates. The development of internet of things (IoT) technology today, this technology can provide solutions for gouramy farmers to overcome these obstacles. Therefore, this research proposes IoT architecture for gouramy cultivation. The IoT architecture proposed in this study has six designs consisting of the domain model, business process hierarchy, IoT layer, deployment, information, and interoperability endpoints. The IoT architecture is expected to build the IoT system in accordance with the needs of gouramy farmers and make it easier for developers to build and develop the system.
DESIGN AND STRESS ANALYSIS OF WHEEL MOBILE ROBOT
Authors: Miková Lubica
Published: February 2021

Urgency of the research. In the context of design of new, improved devices or technical systems containing electronic elements, we are increasingly encountering the concepts like mechatronics, mechatronic systems, mechatronics system solving approach or just simply mechatronics. The impact of mechatronics is most noticeable in mobile mechatronic products, especially in the automotive industry, where mechatronic systems are increasingly being used. Target setting. The design a wheeled chassis with improved ability to cross rugged terrain. Its indivitual parts are subject of simualtions and stress ananlysis, which confirmed the advantage of the chosen design and mobility of the chassis. Actual scientific researches and issues analysis. Designing a robot for a specific purpose always involves several steps. Before considering the design of a robot, it is necessary to determine the environment in which it should operate. The problem
of four or more wheeled chassis arises when the wheels are unsprung and the unevenness of the terrain surface causes loss of wheel contact with the terrain surface and thus loss of traction. Uninvestigated parts of general matters defining. The question of the physical design of a mobile robot is uninvestigated, because it will be solved in future. The research objective. The main aim was design and stress analysis of individual parts of the mobile wheeled robot with improved ability to pass through rugged terrain.
The statement of basic materials. The chassis is based on five modules which are connected between each other. Its steering ability against each other is determined by the upper connection cover. Two modules integrated between wheels are for storage, which can be used for battery sources or auxiliary control. Conclusions. All construction parts of this mobile robot were designed in Solidworks software, taking into account the
simplicity of the structure and its ease of manufacture. The mobile chassis was tested in various terains simulations, where all his movements and terrain adaptation were monitored. The mobile chassis structure was recalculated from the point of view of the mechanics theory.
Pola Kolaborasi Bisnis CV. Promindo Utama
Authors: Ramadhani Hafizah Putri , Setiawan Iwan
Published: February 2021

Collaboration is a process of thinking in which the parties involved look at the different aspects of a problem and find solutions to these differences and their limited views on what can be done. Collaboration is defined as togetherness, cooperation, sharing of tasks, equality, and responsibility where the collaborating parties have the same goal, common perception, willingness to process, and provide mutual benefits. This research is motivated by the fact that the process, mechanism and benefits of collaboration between CV. Promindo Utama and its partners do not always go as desired. This condition can certainly hinder the development of the company and or correct the company to make improvements in collaboration patterns in partnerships. In general, this study aims to determine how the business collaboration patterns built by CV. Promindo Utama with its partners and know the factors that support and tend to hinder the collaboration. This research uses descriptive qualitative research. The data collection used was observation and interviews which were conducted for about 1 month. The results showed that in general the collaboration between CV. Promindo Utama and its partners have been running optimally even though there are still some obstacles. Besides the obstacles that exist, the collaboration pattern that occurs is able to run smoothly.
Sentimentos e vivências dos profissionais da enfermagem no combate ao coronavírus
Authors: Júnior Adilson Mendes de Figueiredo , Brigida Glaucilene Viana Santa , Da Silva Márcia Cristiane Rodrigues , Dos Santos Milene de Nazaré Reis , De Menezes Marcos Vinicius de Mendonça , Dos Santos Tatheanne da Silva Trindade , De Jesus Lorena Matos , Dos Santos Maria Lúcia Costa , Rosário Rita de Cassia Nemer dos Santos , Pinheiro Edeiza Priscila de Souza
Published: February 2021

Esse artigo buscou relatar os sentimentos e vivências de profissionais da área da enfermagem que trabalhavam em um hospital público no combate ao COVID-19 através de um estudo descritivo, tipo relato de experiência elaborado no contexto de estágio curricular obrigatório da disciplina de estágio supervisionado, durante o curso de Graduação em Enfermagem de uma Universidade pública do estado do Pará. O novo Coronavírus (SARS-CoV-2) afetou o trabalho de vários profissionais de saúde que lutaram incansavelmente contra a COVID-19 (Coronavírus Disease 2019). No mundo todo, enfermeiros, médicos, farmacêuticos, biomédicos, psicólogos, entre outros, pagaram um alto preço na luta contra a doença. Todo profissional doente representa um risco para a população, pois além de ser fonte de doenças infecciosas também falta ao trabalho e desfalca sua equipe, além de sobrecarregar os outros profissionais envolvidos. O real impacto da nova pandemia na saúde dos profissionais de enfermagem brasileiros permanece desconhecido. No entanto, doenças causadas por vírus semelhantes ao SARS-CoV-2 possuem um grave impacto negativo na saúde desses profissionais.
O uso de substâncias psicoativas e o estado mental: avaliando a função cognitiva através do Mini Exame do Estado Mental
Authors: De Carvalho João Pedro Satuf Silva , Oliveira Carina Gabriela Andrade , Pinto Carlos Alberto Pereira
Published: February 2021

Objetivo: Avaliar os possíveis efeitos na esfera cognitiva de pacientes usuários de entorpecentes em tratamento no Centro de Atenção Psicossocial – Álcool e Drogas (CAPS AD) de Betim tendo como parâmetro a aplicação do teste do Mini Exame do Estado Mental (MEEM). Métodos: Trata-se de uma pesquisa quantitativa, exploratória, descritiva, baseada em questionário semiestruturado. Foram entrevistados, no período de março a novembro de 2019, 68 indivíduos; sendo 62 homens e 6 mulheres, com idades entre 22 e 69 anos, que utilizaram os serviços proporcionados pelo CAPS AD durante a coleta dos dados. Resultados: Os resultados obtidos após aplicação e interpretação dos questionários demonstram suspeita de deterioração cognitiva nos usuários de drogas, sendo que apenas 13,24% dos pacientes apresentaram resultados adequados no MEEM. Dentre as funções cognitivas avaliadas durante a aplicação do teste, a memória, foi a que apresentou pior resultado. Conclusão: O uso excessivo de substâncias entorpecentes pode ocasionar danos neurológicos severos. As prováveis deteriorações cognitivas apresentadas remontam necessidades de mais estratégias de prevenção (rodas de conversa, dinâmicas, oficinas de memória) e de existências de centros de reabilitação, tal como o CAPS AD de Betim.
O uso da laserterapia associada ao complexo B na prevenção de parestesia do nervo mandibular pós ressecção cirúrgica de ceratocisto odontogênico: relato de caso
Authors: Ribeiro Ana Carolina Freitas , Gonçalves Thalía dos Anjos , Carneiro Marcelo Newton , Carneiro Paula Mendes Acatauassú
Published: February 2021

Objetivo: Relatar um caso clínico e analisar os efeitos da laserterapia de baixa potência associada ao uso de complexo B no tratamento pós-cirúrgico de ressecção de ceratocisto odontogênico na região mandibular direita com intuito de prevenir a parestesia definitiva no nervo mandibular. Detalhamento do caso: Paciente do sexo feminino, 52 anos de idade, compareceu a um consultório particular na cidade de Belém do Pará queixando-se de algia em região posterior de mandíbula direita e dificuldade na mastigação. Ao exame clínico, foi observado discreto aumento de volume intra-oral. Foi relatada algia à palpação e mobilidade do elemento dentário 47. Diante disso, foram solicitados exames de imagem para análise do caso. Considerações finais: O ceratocisto odontogênico consiste em uma patologia que apresenta um grande interesse devido à frequência com que é relatado na literatura e à sua capacidade de se desenvolver na região facial com agressividade, podendo deixar sequelas mutilantes, como a parestesia. Nesse sentido, conclui-se que o uso dessa terapia trouxe benefícios no tratamento da parestesia em um curto período de tempo, visto que a percepção sensorial da paciente ao término do tratamento encontrava-se dentro da normalidade.
Enfermagem frente ao suicídio infanto-juvenil
Authors: De Menezes Júlia Góes , Baptista Suelen Suzy Gomes , Lopes Graciana de Sousa
Published: February 2021

Objetivo: Discutir os aspectos relacionados ao suicídio infanto-juvenil. Métodos: Trata-se de uma revisão integrativa da literatura com coleta de dados por meio de levantamento bibliográfico, os levantamentos de dados foram coletados nas bibliotecas virtuais LILACS, BVS e SCIELO, sendo inclusos artigos publicados nos últimos 10 anos de 2009 a 2019. Resultados: A partir da análise de conteúdo dos materiais coletados a fim de responder as questões de pesquisa, emergiram-se então as seguintes categorias: I) Fatores que levam a criança/adolescente ao suicídio; II) Ações que salvam vidas, que mostram a importância da família no reconhecimento dos fatores de risco e no tratamento da criança/adolescente que passa por ideação suicida ou que já tentou o suicídio, além de relatar meios de ajudar esse grupo e discutir o que leva o infanto-juvenil a cometer este ato. Considerações finais: O suicídio afeta tanto quem comete o ato quanto quem convive com o suicida.
Tıp Öğrencilerinin Probleme Dayalı Öğrenim Oturumlarında Kullanılan Senaryo Tanıtım Resimleri Hakkındaki Görüşleri: Niteleyici bir Çalışma
Authors: EDİRNE Tamer , ÖZDEMİR Serdar
Published: February 2021

AmaçTıp eğitiminde iyi hekimler yetiştirmede görsel sanatların katkısı olduğu iddia edilmektedir. Probleme dayalı öğrenim yapan tıp fakültelerinde oturumlarda kullanılan yazılı senaryoların ilk sayfalarında genellikle konu ile ilgili görsel eserler (resim, fotoğraf, çizim) bulunmaktadır. Bu çalışmanın amacı, senaryolarının ilk sayfasında yer alan görsel sanat eserleri hakkında tıp öğrencilerinin düşüncelerini araştırmak ve iyi hekimlik ilkeleri ile karşılaştırmaktır.Gereç ve yöntemBu çalışmada veriler nitel veri toplama tekniği kullanıldı ve veriler odak grup görüşmesi ile elde edildi. Amaçlı örneklem yöntemine uygun olarak seçilen dönem üç öğrencilerine senaryo tanıtım resimleri hakkındaki düşünceleri soruldu. Verilerin analizi aşamasında betimsel analiz ve içerik analizi yöntemlerinden yararlanıldı. BulgularToplam 10 öğrenci ile tamamlanan çalışmada katılımcıların senaryo kapak sayfasındaki görsel ürünler hakkındaki görüşleri dört ana başlık altında toparlandı: yansıtma, empati, farkındalık ve yaratıcılık.Yapılan analizlerde öğrencilerin resimlerde yer alan hastaların kendi hastalık deneyimlerini hatırlattığını ve kendi sağlık-hastalık tecrübeleri ile benzerlik kurduklarını saptadık. Öğrencilerin resimlerdeki hastalara bakarak hastaların duyguları, amaçları, beklentileri olan insanlar olduklarını anladıklarını belirledik. Bu konuda kendilerini eksik hissettiklerini ve buna hazırlıklı olmadıklarını anladıklarını ortaya koyduk. Öğrenciler hastaların yüzlerinden bir şeyler okumanın mümkün olduğunu ve bu resimlerin buna yardımcı olduğunu fark ettiler. Hastaları bir resim gibi okuyup, uyarıları fark etmek için resimlerin faydalı olabileceğini bildirdiler. Öğrenciler resimlerin yorumlanması ile aydınlandıklarını ve bu farklı bakış açısının hastalarda da işe yarayabileceğini anladılar. Sonuç Bu çalışma tıp eğitiminde görsel sanatların iyi hekimlik ilkeleri ile uyumlu olduğunu desteklemektedir. Senaryo kapak resimlerinin uygun şekilde ele alınması ve aktif olarak kullanılması öğrencilerin yansıtma, empati, farkındalık ve yaratıcılık konularında gelişmelerine katkı sağlayabilir ve iyi hekimlik konusunda yardımcı olabilir.
Medical genetic study of the Republic of North Ossetia Alania. II. Nosological spectrum of hereditary pathology in three districts
Authors: Гетоева З.К. , Кадышев В.В. , Джаджиева М.Ю. , Галкина В.А. , Перепелов А.В. , Михайлова Л.К. , Тебиева И.С. , Гинтер Е.К. , Зинченко Р.А.
Published: February 2021

Представлен нозологический спектр моногенных наследственных болезней (МНБ) в трех районах Республики Северная Осетия Алания (РСОА) - Правобережном, Ардонском и Кировском, общей численностью 119 590 человек. Обследовано все население районов по протоколу генетико-эпидемиологических исследований (разработка ФГБНУ «МГНЦ»), выявлено и диагностировано 600 пациентов (из 418 семей) с различными МНБ. Всего выявлено 135 нозологических форм - 65 с аутосомно-доминантным типом наследования (АД), 57 с аутосомно-рецессивным (АР) и 14 с Х-сцепленным (Х-сц.). Определены распространенность заболеваний, частые и редкие нозологические формы. Проведено сравнение нозологического спектра и распространенности отдельных МНБ с таковыми в ранее обследованных популяциях европейской части России. Выявлены особенности разнообразия МНБ. Более высокие значения распространенности, чем в других популяциях РФ выявлены синдром Элерса-Данло, миотоническая дистрофия, несиндромальная умственная отсталость с различными типами наследования, различные формы пигментного ретинита и др. Ряд заболеваний, частых в обследованных регионах РФ, наоборот, встречались реже - вульгарный ихтиоз, нейрофиброматоз, наследственная моторно-сенсорная нейропатия и ихтиозиформная эритродеремия.

In this article we present the nosological spectrum of monogenic hereditary diseases (MHD) in three districts of the Republic of North Ossetia - Alania (RNOA) - Pravoberezhny, Ardonsky and Kirovsky, with a total population of 119,590 people. The entire population of the districts was examined according to the Protocol of genetic and epidemiological studies (developed by the Federal state budgetary Research Centre for Medical Genetics), 600 patients (from 418 families) with various NBS were identified and diagnosed. We identified 136 nosological forms of MHD - 65 with autosomal dominant type of inheritance (AD), 57 with autosomal recessive (AR) and 14 with X-linked (X-lin.). We determine the prevalence of diseases, frequent and rare nosological forms. The nosological spectrum and prevalence of individual MHD were compared with previously surveyed populations in the European part of Russia: Kirov, Kostroma, Arkhangelsk, Tver, Bryansk, Rostov regions, Krasnodar territory and the Republics of Karachay-Cherkessia, Adygea, Tatarstan, Bashkortostan, Mari El, Udmurtia and Chuvashia. Features of the MHD diversity are revealed. With higher prevalence values than in other populations of the Russian Federation, Ehlers-Danlo syndrome, myotonic dystrophy, non - syndromic mental retardation with various types of inheritance and various forms of retinitis pigmentosa, etc. A number of diseases that are frequent in the Russian Federation have shown on the contrary lower prevalence values - vulgar ichthyosis, neurofibromatosis, hereditary motor-sensory neuropathy and ichthyosiform erythroderemia.
Reduction of serotonin receptor 2A protein level in peripheral blood lymphocytes during antipsychotic medication is biomarker of therapy safety
Authors: Заботина А.М. , Грунина М.Н. , Волкова Е.В. , Насырова Р.Ф. , Тараскина А.Е.
Published: February 2021

В лимфоцитах периферической крови (ЛПК) в группе пациентов с коморбидным течением шизофрении с синдромом алкогольной зависимости показаны более низкие значения количества белка рецептора 5-НТ2А и уровня его мРНК по сравнению с группой с неотягощенной психической патологией (р<0.001). Безопасная фармакотерапия ассоциирована со снижением количества рецептора 5-НТ2А в ЛПК на 28-й день без изменения уровня транскрипции гена, возможно вызванного интернализацией рецептора.

We studied mRNA and protein levels of serotonin receptor 2A (5-НТ2А) in lymphocytes of schizophrenia patients both before and after 28 days of antipsychotic therapy in order to estimate biomarkers of efficacy and safety of the treatment. We found lower mRNA and protein levels of 5-НТ2А in peripheral blood lymphocytes (PBL) of schizophrenia patients with alcohol addiction syndrome than in PBL of schizophrenia patients without addictions (р<0.001). Absence of common adverse side effects (antipsychotic-induced weight gain, parkinsonism, akathisia) during antipsychotic therapy was associated with reduction of 5-НТ2А protein level in PBL by 28th day of the treatment, while HTR2A mRNA level was not changed. Reduction of 5-НТ2А protein level in PBL by 28th day may be a potential biomarker of the antipsychotic therapy safety.
Ethical challenges of preimplantation genetic testing
Authors: Гребенщикова Е.Г.
Published: February 2021

Рассматриваются основные этические вызовы предимплантационного генетического тестирования (ПГТ), раскрывается взаимосвязь этической проблематики экстракорпорального оплодотворения и ПГТ, анализируются социальные аспекты применения ПГТ.

The main ethical challenges of preimplantation genetic testing (PGT) are examined, the relationship between the ethical issues of IVF and PGT is revealed, the social aspects of the use of PGT are analyzed.
Ethical and legal problems of commodification of biomaterials in the development of genomics and genomic medicine
Authors: Попова О.В.
Published: February 2021

В статье рассмотрен ряд этико-правовых проблем коммодификации биоматериалов в процессе развития геномики и геномной медицины. Показано, что биоматериалы в современном мире рассматриваются как объекты имущественного и патентного права и становятся источником получения прибыли. Зачастую это приводит к появлению казусов, связанных с защитой прав индивида, являющегося источником происхождения биоматериалов. Выдвинут тезис о том, что ситуация, связанная с оборотом биоматериалов, отражается в различных модусах отношений между индивидом, наукой и обществом, с характерной для каждого из них артикуляцией приоритета личного или общественного блага.

The article considers a number of ethical and legal problems of commodification of biomaterials in the development of genomics and genomic medicine. It is shown that biomaterials in the modern world are considered as objects of property and patent law and become a source of profit. Often this leads to the appearance of incidents related to the protection of the rights of the individual, which is the source of origin of biomaterials. The thesis is put forward that the situation associated with the circulation of biomaterials is reflected in various modes of relations between the individual, science and society, with the articulation of the priority of a personal or public good characteristic of each of them.
Sociological aspects of genetic carrier screening for autosomal recessive disorders
Authors: Ревазян К.З. , Мешков А.Н. , Ершова А.И. , Глечян А.М. , Сивакова О.В. , Войнова Н.А. , Волков А.К. , Драпкина О.М.
Published: February 2021

Генетический скрининг на носительство вариантов, вызывающих развитие аутосомно-рецессивных заболеваний является важным звеном профилактики наследственных заболеваний на этапе планирования семьи. Пациентам поликлиники НОМТЦ МГТУ им. Н.Э. Баумана в возрасте 18-49 лет (женщины) и от 18 лет (мужчины) было предложено ознакомиться с брошюрой о генетическом скрининге на носительство вариантов, вызывающих развитие аутосомно-рецессивных заболеваний и заполнить анонимный опросник для выявления отношения к скринингу. Анкетирование продемонстрировало положительное отношение участников к проведению генетического скрининга, так как 73% опрошенных изъявили желание пройти скрининг, но у 46% были опасения касательно его возможных негативных последствий. При дальнейшем внедрении генетического скрининга на носительство вариантов, вызывающих развитие аутосомно-рецессивных заболеваний, в систему здравоохранения важно организовать просветительскую работу, информирующую население о роли скрининга и для устранения нежелательных последствий.

Genetic carrier screening for autosomal-recessive disorders is an important part of hereditary diseases prevention at the stage of family planning. Patients of the Bauman clinic (18-49 years old women and men older 18 years) were asked to read a brochure about carrier screening for autosomal-recessive disorders and fill out an anonymous questionnaire to identify their attitudes towards screening. The questionnaire showed a positive attitude of the participants towards genetic screening, as 73% of respondents expressed a desire to undergo screening, but 46% had concerns about its possible negative consequences. With the further implementation of carrier screening by the healthcare system, it is important to organize educational work that will inform the population about the role of screening and for eliminating undesirable consequences.
Genetic factors of predisposition to hereditary forms of thrombophilia in women with high-risk pregnancy
Authors: Ратникова С.Ю. , Жукова Т.П. , Зайцева Е.С. , Конева Т.Г.
Published: February 2021

В настоящее время огромное значение имеет оценка генетических факторов, приводящих к риску тромбоэмболических осложнений у беременных женщин. Проведено исследование полиморфизма генов системы гемостаза (F5 (G1691А), F2 (G20210A), SERPINC1(G786A), PROC(A2583T)) методом полимеразной цепной реакции в режиме реального времени у 63 пациенток с отягощенным акушерским анамнезом. Показано, что присутствие в генотипе у 48 пациенток (76%) одного или сочетания нескольких низкофункциональных аллелей исследуемых генов является фактором риска развития тромбофилических осложнений беременности (фетоплацентарной недостаточности, угрозы прерывания, преэклампсии, преждевременной отслойки нормально расположенной плаценты, антенатальной гибели плода).

Estimation of genetic factors that lead to risk of thromboembolic complications in pregnant women, has a great importance in current time. Investigation of gene polymorphisms of hemostatic system (F5 (G1691А), F2 (G20210A), SERPINC1(G786A), PROC(A2583T)) with application of real time polymerase chain reaction in 63 patients with aggravated obstetric anamnesis was done. It was shown that the presence in the genotype of 48 patients (76%) of one or a combination of several low-functional alleles of the studied genes is a risk factor for the development of thrombophilic pregnancy complications (fetoplacental insufficiency, threatening miscarriage, preeclampsia, premature detachment of normally situated placenta, intrauterine fetal death).
Increased methylation of gene promoters in the trophoblast of spontaneous miscarriages with trisomy 16
Authors: Васильев С.А. , Толмачева Е.Н. , Васильева О.Ю. , Никитина Т.В. , Саженова Е.А. , Марков А.В. , Сердюкова Е.С. , Лебедев И.Н.
Published: February 2021

Обнаружен повышенный уровень нарушений эпигенетической регуляции экспрессии генов в трофобласте хориона спонтанных абортусов с трисомией 16. Среди гиперметилированных генов была значимо обогащена группа генов секретируемых белков, значительное количество генов кодировали рецепторы и транскрипционные факторы. Гиперметилирование выявленных генов является потенциальной причиной гибели эмбрионов с трисомией 16 на ранних стадиях развития.

An increased level of abnormal epigenetic regulation of gene expression in the trophoblast of spontaneous miscarriages with trisomy 16 was found. Among the hypermethylated genes, the group of genes of secreted proteins was significantly enriched, and a significant number of genes encoded receptors and transcription factors. Hypermethylation of the identified genes is a potential cause of death of embryos with trisomy 16 in the early stages of development.
DNA-methylation analysis of differentially expressed genes in fibroblast cell-lines, derived from monozygotic twins discordant for Parkinson’s disease
Authors: Рыболовлев И.Н. , Власов И.Н. , Алиева А.Х. , Сломинский П.А. , Шадрина М.И.
Published: February 2021

Болезнь Паркинсона (БП) является многофакторным гетерогенным нейродегенеративным заболеванием. Поскольку этиопатогенез БП недостаточно изучен, кроме поиска и анализа изменений на уровне ДНК, необходимо распространить фокус исследований на другие уровни: транскриптом и метилом. Изменения на уровне эпигенома можно исследовать у лиц с идентичной генетической конституцией, такой «моделью» являются дискордантные по этому заболеванию монозиготные близнецы. В исследовании приняло участие 3 пары фенотипически и генотипически монозиготных близнецов русского происхождения; В исследовании приняло участие 3 пары фенотипически и генотипически монозиготных близнецов русского происхождения. БП была уточнена у одного из каждой пары близнецов; длительность течения болезни у близнеца с БП составило по меньшей мере 7 лет.; длительность течения болезни у близнеца с БП составила по меньшей мере 7 лет. Были проанализированы метиломы крови и отобраны точки варьирующегося метилирования. Нами было найдено 8 дифференциально экспрессирующихся генов, которые могут быть дифференциально метилированы. Были выявлены различия между здоровым близнецом и близнецом с БП по уровню метилирования ДНК для ряда этих генов в клеточных линиях фибробластов. Полученные нами данные могут указывать на участие процесса ДНК-метилирования в регуляции транскрипции кандидатных генов-участников патогенеза БП.

In recent years it has been convincingly demonstrated that genetic factors play an important role in progression of Parkinson’s disease (PD). Since the etiology of PD has not been elucidated completely yet, it is crucial to shift focus of the research to the broader areas - to dive into investigations of methylome and transcriptome. Epigenetic regulation of gene expression may take part in pathogenesis of PD. Changes in epigenome can be conveniently investigated in case of individuals with almost identical genetic makeup, and monozygotic twins discordant for PD may be such “model”. 3 pairs phenotypically and genotypically monozygous twins of Russian ancestry were enrolled in the study. PD was diagnosed in one of each pair. The disease duration was at least 7 years. Data on blood methylomes was analyzed. Points of variable methylation in blood methylomes were selected. With this approach, 8 differentially expressed genes were found that also may be differentially methylated. Changes in methylation level for some of this genes were found in monozygotic twins discordant for PD fibroblasts cell-lines between healthy and afflicted siblings. Acquired data might suggest participation of DNA-methylation in transcription regulation of PD pathogenesis-related candidate genes.
ANALYSIS OF ASSOCIATIVE SOCIAL INTERACTION PROCESSES BETWEEN THE STUDENT COUNCIL IN JUNIOR HIGH
Authors: Aziz Abdul
Published: February 2021

The study aims to determine the associative cooperation between board and accommodation OSIS SMP Islam Ashabul Kahfi Pontianak in West Borneo period 2015-2016. The method used is descriptive with problem solving procedures investigeted by describing or depicting the state of the subject or object of research. In the study sample are seven members of the total board OSIS twenty four members. The analysis showed that the cooperation between board OSIS has worked well for the cooperation ehich is always enhanced by the whole OSIS and coaching are continually done by coach OSIS SMP Islam Ashabul Kahfi Pontianak, although still les than perfect because of several obstacles that accur within board OSIS.
Interaksi Sosial Antar Siswa Muslim Dengan Non Muslim Di Kelas XI IPS (Studi Di SMA Negeri 1 Nanga Taman Kabupaten Sekadau)
Authors: Deden Deden
Published: February 2021

The purpose of this research is to know the cooperation, accommodation, and competition among Muslim non-Muslim students of class XI IPS SMAN 1 Nanga Taman. The research methodology that is used is observation technique, interview, and documentation study while, the tools of data collecting are observation, interview, and documentation. The results showed social interaction between the Muslim and non- Muslim students through spontaneous cooperation, undertaken without orders from anyone, direct cooperation, which is done at the behest of students by teachers, students do not differentiate between Muslims and non-Muslims. Accommodation in the form of tolerance, mutual respect, and respect, compromise when students discuss the group to get the maximum results, while the individual competition is the competition in gaining success in learning, competing to earn achievements, then the competition groups that compete for presenting the best presentation in the discussions, case this relates to learning activities in class and outside of class.
Analisis Bentuk Karakter Dalam Penggunaan Media Sosial Pada Siswa SMP Kota Pontianak (Studi Kasus Di SMP Negeri Dan Swasta)
Authors: Ardiansyah Mukhlis Novi
Published: February 2021

The purpose of this study is to Analysis Character Forms in the Use of Social Media in Pontianak City Junior High School Students (Case Study in Public and Private Junior High Schools) the character shape of students in the use of social media, is good, namely, students are able to discipline and be responsible regarding the use of social media both at school and outside school. The form of character taught to public and private junior high school students in Pontianak always be honest, disciplined, and responsible, protecting themselves from negative social media. Social media that are often used by public and private junior high school students in Pontianak, what's an app, Facebook, Instagram, and online games. The impact of the use of social media on state and private junior high school students in Pontianak City, for schools students, are given extra supervision so that social media misuse does not occur.
Peran Kegiatan Kepramukaan Dalam Menanamkan Sikap Solidaritas Organik Pada Siswa Kelas X SMA Negeri 1 Kayan Hulu
Authors: M Sriyati
Published: February 2021

The purpose of this research is to know the role of scout leader by planting organic solidarity, the method used is qualitative descriptive. Data collection techniques are observation, interview and documentation study, data collection tools guide observation, interview, and documentation. The results of research through the moral sense, all team members observe the material provided scoutmaster, mutual trust, discussion or deliberation trying to receive opinions and always accept what the decision and is ready to accept criticism, accept feedback and criticism from the other members, through the emotional experience, the role of scoutmaster realized learners to always be able to hold back the emotion and not reckless, dare to give presumption that feels right and can be held responsible or what you do, do not break the rules set by senior and promised to anyone, including the tasks given in planting organic solidarity in SMA Negeri 1 Kayan Hulu.
ECONOMIC POLICY TO OVERCOME STAGNATION AFTER THE FINANCIAL CRISIS
Authors: Kuligin V. D.
Published: February 2021

The article considers the downward spiral of deflation, its causes and consequences. The paper discusses the compression of aggregate demand and the subsequent recession. The study discloses the content of the liquidity trap created by the behavior of borrowers. The author traces the connection between the events of the “lost decades” in Japan and the stagnation of production in leading Western countries after the global financial crisis. In both cases, the large-scale use of fiscal and monetary incentives did not cause a sharp rise in business activity. The paper concludes that the operation of the market mechanism is blocked by budget and monetary policies. Obstacles to entrepreneurial activity and energy lead to the loss of necessary information generated by market agents. This circumstance prolongs the stagnation of the economy.
THE ROLE OF INNOVATIONS IN RENEWAL OF FIXED CAPITAL OF ORGANIZATIONS
Authors: Astafieva O. E. , Kozlovsky A. V. , Moiseenko N. A.
Published: February 2021

The paper investigates modern trends in the development of innovative systems in Russia. These trends are caused, on the one hand, by the lack of a clearly formulated concept of an innovation system, and, consequently, by the inability to determine the ways of its development, and by the active use of undeservedly forgotten program-target planning methods, on the other hand. A detailed analysis of various positions and statistical materials allowed us to prove that, contrary to the generally accepted opinion, the Russian model of public administration and financing of innovative activities has signs of cluster and state-corporate types. The article considers the existing approaches to the management of innovation and investment activities of organizations, which is aimed directly at reproduction processes, in particular, the reproduction of fixed capital. The authors substantiate the necessity of creating territorially grouped innovation systems, which is explained by the dependence of industries and sectors of the economy on each other on the technological principle and the need to create technological links between them to realize their potential advantages within the framework of the implementation and creation of innovative products.
STRATEGY FOR OPTIMIZING INTERNAL AUDITING FINANCIAL CONTROL OF THE COMPANY DURING THE ECONOMIC CRISIS
Authors: Gladysheva A. V. , Makhonina I. N. , Chepurova I. F.
Published: February 2021

The article considers the process of strategic transformation of the company’s internal audit as an effective form of the financial control system, which is a structurally branched set of interrelated links. The paper analyses various aspects of organization management in the context of global crisis phenomena in socio-economic and other spheres. The author proposes a set of measures to adapt the company to work during the Covid-19 pandemic impact on the economy. The study clarifies fundamentally new requirements to the content of the internal audit service specialists` functionality and the nature of their interaction with top management representatives. The paper outlines the prospects of professional development of the auditor in modern conditions.
DESIGN FEATURES OF MANAGEMENT SYSTEMS ENTERPRISES OF THE PETROCHEMICAL COMPLEX
Authors: Barsegyan N. V.
Published: February 2021

Restructuring, redesigning or designing the organizational management structure on a scientific basis at domestic petrochemical enterprises are tools for improving the management system in the context of transition to new management standards, which contributes to the most effective achievement of goals. The article summarizes and analyses methods and approaches for designing organizational management structures and methods for their evaluation. In the development strategy of petrochemical enterprises aimed at resource conservation and the development of new petrochemical products, flexible organizational management structures are recommended, the design of which requires the use of a set of methods with the integration of the advantages of each of them. For proper management decision-making, it is necessary to develop a balanced system of indicators, in connection with which the author proposes the key indicators that characterize the effectiveness of the management system – technological, managerial, economic. The paper develops the functional model of modernization of the organizational management structure according to strategy of development of the enterprise based on the IDEF0 methodology. The study proposes the model of lean strategy for the development of the organizational structure of petrochemical enterprise management, as the integration of business strategic management systems, production organization and personnel training, based on the project management approach.
mwfn: A Strict, Concise and Extensible Format for Electronic Wavefunction Storage and Exchange
Authors: Lu Tian , Chen Qinxue
Published: February 2021

Analysis of electronic wavefunction generated by quantum chemistry codes has crucial role in exploring nature of electronic structure and providing valuable information of chemical interest. A file containing wavefunction information is inevitably needed as a communicator between wavefunction analysis codes and quantum chemistry programs. There have been many available formats designed for recording wavefunction, such as .fch, .molden, .wfn, .wfx and so on, however they all have different flaws and thus bringing evident inconvenience for development of new wavefunction analysis codes. To overcome this problem, in this article we define a new format "mwfn" (acronym of "Multiwfn wavefunction file") for electronic wavefunction storage and exchange purposes. This format is strict, concise, extensible, and able to provide all kinds of information for common wavefunction analyses. Since the "mwfn" format fully eliminates all shortcomings of existing formats, we expect it will become a standard for recording wavefunction in the field of wavefunction analysis and quantum chemistry.