bluuebunny/crossref_metadata_2025 huggingface dataset:
Does Multisession Cathodal Transcranial Direct Current Stimulation of the Left Dorsolateral Prefrontal Cortex Prime the Effects of Cognitive Behavioral Therapy on Fear of Pain, Fear of Movement, and Disability in Patients with Nonspecific Low Back Pain? A Randomized Clinical Trial Study
Authors: Ehsani Fatemeh , Hafez Yousefi Mohaddeseh Sadat , Jafarzadeh Abbas , Zoghi Maryam , Jaberzadeh Shapour
Published: September 2023

Many studies have shown that low back pain (LBP) is associated with psychosomatic symptoms which may lead to brain changes. This study aimed to investigate the effect of the concurrent application of cognitive behavioral therapy (CBT) and transcranial direct electrical stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on fear of pain, fear of movement, and disability in patients with nonspecific LBP. This study was performed on 45 LBP patients (23 women, 22 men; mean age 33.00 ± 1.77 years) in three groups: experimental (2 mA cathodal tDCS (c-tDCS)), sham (c-tDCS turned off after 30 s), and control (only received CBT). In all groups, CBT was conducted for 20 min per session, with two sessions per week for four weeks. Fear of pain, fear of movement, and disability were evaluated using questionnaires at baseline, immediately after, and one month after completion of interventions. Results indicated that all three different types of intervention could significantly reduce fear and disability immediately after intervention (p > 0.05). However, improvement in the experimental group was significantly higher than in the other groups immediately after and at the one-month follow-up after interventions (p < 0.05). DLPFC c-tDCS can prime the immediate effects of CBT and also the lasting effects on the reduction in the fear of pain, fear of movement, and disability in LBP patients.
Combating Loneliness in Older Adults during the COVID-19 Pandemic: Findings from a Volunteer-Based Program in Greece
Authors: Balta Marianna , Katsas Konstantinos , Grigoropoulou Chrysoula , Diamantis Dimitrios V. , Kalogiannis Dimitrios , Drougos Nikolaos , Fagogeni Eleni , Veloudaki Afroditi , Panagiotakos Demosthenes , Linos Athena
Published: September 2023

The COVID-19 pandemic has exacerbated the feeling of loneliness, especially among older adults. This study aims to investigate any association between COVID-19 cases in Greece and the number of Loneliness Helpline calls at the Friendship at Every Age program and to assess whether the interconnection part of the program, which interconnects older adults with volunteers, can combat loneliness/social isolation in older adults. This is a supportive, volunteer-based, social intervention program. A total of 4033 calls were collected from July 2020 to November 2022, in Greece. Older adults who participated in the interconnection part completed baseline (n = 275) and follow-up questionnaires (n = 168), including the UCLA Loneliness Scale. A time-series analysis revealed a positive association in the number of calls with COVID-19 cases (Incidence Rate Ratio per 100 new COVID-19 cases = 1.012; Confidence Interval (95% CI) [1.002, 1.022]). A significant decrease in the Loneliness Scale was observed at follow-up [difference = −0.85; 95% CI (−1.16, −0.54)], with similar results by sex, educational level, and area of living. Loneliness Helpline calls increased during COVID-19 outbreaks, while the interconnection part had a positive impact on older adults, reducing their feeling of loneliness. Similar initiatives are required to better address the needs of the ageing population during and after health crises.
An Analysis of Systems of Influences through the Lens of Balanced Time Perspective: A Qualitative Study on a Group of Inmates
Authors: Zarbo Rita , Zammitti Andrea , Lodi Ernesto , Magnano Paola
Published: September 2023

To respond to the increasing challenges of the XXI century, career guidance is used as a device to reduce inequalities, to expand the range of opportunities for all people, to deconstruct the stereotypes and the stigmatizations that tend to relegate specific social categories to particular working niches, and to offer people the chance to express their differences and diversities. This study reports the results of research aimed at understanding the dynamics of career construction in people with imprisonment experience through the exploration of their systems of influences; the stories of the inmates were collected using My System of Career Influences (MSCI). In the analysis of the narratives and the systems of influences, the focus was placed on the balanced time perspective as a core dimension to foster career construction and to look at future possibilities. The results show that the participants are mainly focused on the past, and their focus on the present is narrow and seems to represent a moment of stalemate, preventing the possibility for inmates to imagine their future. Suggestions for practical implications of career counseling for inmates are provided, and the knowledge about the temporal orientation of prisoners will enable those who do not show any hope of achieving positive interactions to be reached and provide a higher degree of individualization for social rehabilitation proposals.
Perceptive Biases in Construction Mediation: Evidence and Application of Artificial Intelligence
Authors: Cao Nan , Cheung Sai-On , Li Keyao
Published: September 2023

In light of advancements in big data analysis and artificial intelligence (AI), there are emerging opportunities to harness these technologies to address perceptive biases. This study examines the potential perceptive biases that may arise when construction mediation is quasi-imposed on the disputing parties. This can happen when mediation attempts are stipulated in the construction contract or court-directed. It is argued that, under such circumstances, a negative perception might arise over whether a bona fide mediation can be realised. Concerns include the fairness and timeliness of the process, as well as the practice of opportunistic mediating behaviours. With data collected from practising construction mediation practitioners in Hong Kong, the constructs of Perceptions of Bona Fide Mediation, Quasi-Imposition, and Positive Mediation Outcomes were first developed. Applying partial least square structural equation modelling to the relationship frameworks of the constructs, it was found that quasi-imposition is not as damaging as envisaged as far as having a bona fide mediation and attaining positive mediation outcomes are concerned. Moreover, a negative perception of the fairness and timeliness of the quasi-imposed mediation would jeopardise the integrity of a bona fide mediation. In this regard, utilizing NLP and machine learning algorithms offers a pioneering AI-driven approach to informing mediating parties, as well as reminding mediators to uphold the fairness and timeliness of the process for the purposes of reaching positive mediation outcomes.
Assessing the Effect of Air Intrusion on Reflective Insulations Performance with Horizontal Heat Flow
Authors: Saber Hamed H. , Yarbrough David W.
Published: September 2023

The determination of thermal resistances (R-values) for enclosed airspaces, including those with one or more low-emittance surfaces, has advanced from one-dimensional heat transfer between large parallel planes to multi-dimensional heat flow in a wide variety of physical configurations. The key elements in this advancement, however, are the evaluation of the heat flow due to conduction-convection and the solution for radiation that includes all surfaces bounding the region of interest. The model used in this study has been validated against several sets of laboratory test data, including the data from the U.S. National Bureau of Standards for the thermal resistance of airspaces, which has been the basis for handbook values for reflective airspaces for five decades. In addition, this model has been previously used to determine the reductions in the R-values of reflective insulations assemblies due to imperfect installations and internal defects in multilayer reflective systems with cross-airflow between the layers. In this study, the model is used to examine the impact on R-value of air intrusion of different air changes per hour (ACH) at various exterior air temperatures into reflective insulation assemblies with a range of effective emittance from 0 to 0.82. Two cases are considered in this study. In the first case, called “infiltration”, exterior air enters the assembly through an opening located in the hot side of the assembly and exits through another opening located in the cold side of the assembly. In the second case, called “wind washing”, the exterior air enters the assembly through an opening located in the hot side of the assembly and exits through another opening located in the same side of the assembly. To quantify the reductions in the R-values due to infiltration and wind washing conditions, a reference case is included in this study for the case in which no air intrusion occurs in the reflective insulation assemblies. Finally, consideration is given to investigating the effect of the aspect ratio on the R-values of reflective insulation assemblies without air intrusion and with air intrusion of different ACH at various exterior air temperatures. The results show that the aspect ratio has a significant impact on the R-value of reflective insulation assemblies with and without air intrusion. Additionally, the results show that the impact of infiltration and wind washing on R-values of reflective insulation assemblies increase as the difference between the exterior air temperature and the undisturbed temperature of the cavity increases.
Developing Supplemental Instructional Videos for Construction Management Education
Authors: Barnes Andrew F. , McCoy Andrew P. , Warnick Quinn
Published: September 2023

Technological advancements and lower production costs since the mid-1990s have dramatically improved opportunities for instructors to tailor self-made instructional videos for their students. However, video production technology has outpaced the development of educational theory, causing instructional videos to consistently fall short of their pedagogical potential. Responding to these shortcomings, scholars from various backgrounds have started publishing guidelines to help practitioners as they develop instructional videos for their respective fields. Using a rapid literature review, this article contributes to this ongoing effort by synthesizing theory-based, best-practice guidelines for a specific subcategory of educational videos called supplemental instructional videos (SIVs). SIVs are different from other types of instructional videos in that they are used to support and magnify other learning methods, mediums, and materials rather than substitute for them. Bringing the best-practice guidelines synthesized in this paper immediately into application, they were used to inform the production of SIVs for an undergraduate course that was held in the Building Construction Department of a major public university in the United States during the Spring 2020 semester. The methods used in the production of the SIV guidelines were systematically documented during the course for future researchers and practitioners to learn and build from.
Health Risk Assessment of Inhalable Dust Exposure during the Welding and Grinding Process of Subway Aluminum Alloy Components
Authors: Li Can , Han Duanjun , Wei Xiaoqing , Yang Jinlin , Wu Chunlong
Published: September 2023

The subway factory industry is developing rapidly in China, but there are some occupational health risk assessments of inhalable dust in this industry. Therefore, this study aimed to explore the contamination level and health risks of dust in an aluminum alloy body workshop of subway factories in Hunan Province, China. A total of 160 dust samples were collected from the welding and grinding areas. The main elements of PM10 were analyzed. The health risks of aluminum dust and PM2.5 were evaluated. The Monte Carlo method was adopted to compare the sensitivity of the Hazard Quota (HQ) of aluminum dust and carcinogenic risk (CR) of PM2.5 to the exposure parameters for workers. The results showed that the PM10 concentration in the grinding area was higher, while the PM2.5 concentration in the welding area was higher. The metal element with a mass fraction of 27.7% was aluminum. In both areas, the probability of the aluminum dust HQ exceeding 1 was approximately 17% and 68%, respectively. The PM2.5 CR exceeded the acceptable upper limit value (1.0 × 10−4). The main risk factor of aluminum dust HQ was concentration, while the main risk factors of PM2.5 CR were concentration and exposure duration. These findings provide basic data for enhancing health risk management in the subway industry.
Recent Advances in Graphene-Based Mesoporous Nanosheets for Supercapacitors
Authors: Bo Wenbei , Zhang Hongtao , Yin Guocheng , Zhang Liangzhu , Qin Jieqiong
Published: September 2023

Among typical energy storage devices, supercapacitors play a predominant role in industry and our life owing to their rapid charge/discharge rate, superior lifespan, high power density, low cost, and outstanding safety. However, their low energy density has severely hindered their further development. For active electrode materials, graphene-based mesoporous nanosheets (GMNs) can combine the advantages from graphene and mesoporous materials, which can be applied to significantly enhance the energy density of supercapacitors. Here, we review the recent advances in GMNs for supercapacitors, focusing on in-plane mesoporous graphene and sandwich-like graphene-based heterostructures. Firstly, the synthesis of in-plane mesoporous graphene with ordered and disordered mesopores for supercapacitors is introduced. Secondly, sandwich-like graphene-based heterostructures are classified into mesoporous carbon/graphene, mesoporous heteroatom-doped carbon/graphene, mesoporous conducting polymer/graphene, and mesoporous metal oxide/graphene, and their applications in supercapacitors are discussed in detail. Finally, the challenges and opportunities of GMNs for high-performance supercapacitors are proposed.
Density Functional Theory Analysis of the Impact of Boron Concentration and Surface Oxidation in Boron-Doped Graphene for Sodium and Aluminum Storage
Authors: Ritopečki Milica S. , Skorodumova Natalia V. , Dobrota Ana S. , Pašti Igor A.
Published: September 2023

Graphene is thought to be a promising material for many applications. However, pristine graphene is not suitable for most electrochemical devices, where defect engineering is crucial for its performance. We demonstrate how the boron doping of graphene can alter its reactivity, electrical conductivity and potential application for sodium and aluminum storage, with an emphasis on novel metal-ion batteries. Using Density Functional Theory calculations, we investigate both the influence of boron concentration and the oxidation of the material on the mentioned properties. It is demonstrated that the presence of boron in graphene increases its reactivity towards atomic hydrogen and oxygen-containing species; in other words, it makes B-doped graphene more prone to oxidation. Additionally, the presence of these surface functional groups significantly alters the type and strength of the interaction of Na and Al with the given materials. Boron-doping and the oxidation of graphene is found to increase the Na storage capacity of graphene by a factor of up to four, and the calculated sodiation potentials indicate the possibility of using these materials as electrode materials in high-voltage Na-ion batteries.
Tumor Location Impacts the Development of Radiation Necrosis in Benign Intracranial Tumors
Authors: Demetz Matthias , Mangesius Julian , Krigers Aleksandrs , Nevinny-Stickel Meinhard , Thomé Claudius , Freyschlag Christian F. , Kerschbaumer Johannes
Published: September 2023

Background: Radiation necrosis (RN) is a possible late complication of stereotactic radiosurgery (SRS), but only a few risk factors are known. The aim of this study was to assess tumor location in correlation to the development of radiation necrosis for skull base (SB) and non-skull base tumors. Methods: All patients treated with radiosurgery for benign neoplasms (2004–2020) were retrospectively evaluated. The clinical, imaging and medication data were obtained and the largest axial tumor diameter was determined using MRI scans in T1-weighted imaging with gadolinium. The diagnosis of RN was established using imaging parameters. Patients with tumors located at the skull base were compared to patients with tumors in non-skull base locations. Results: 205 patients could be included. Overall, 157 tumors (76.6%) were located at the SB and compared to 48 (23.4%) non-SB tumors. Among SB tumors, the most common were vestibular schwannomas (125 cases) and meningiomas (21 cases). In total, 32 (15.6%) patients developed RN after a median of 10 (IqR 5–12) months. Moreover, 62 patients (30.2%) had already undergone at least one surgical resection. In multivariate Cox regression, SB tumors showed a significantly lower risk of radiation necrosis with a Hazard Ratio (HR) of 0.252, p < 0.001, independently of the applied radiation dose. Furthermore, higher radiation doses had a significant impact on the occurrence of RN (HR 1.372, p = 0.002). Conclusions: The risk for the development of RN for SB tumors appears to be low but should not be underestimated. No difference was found between recurrent tumors and newly diagnosed tumors, which may support the value of radiosurgical treatment for patients with recurrent SB tumors.
Synergistic Effects of Metformin and Trastuzumab on HER2 Positive Gastroesophageal Adenocarcinoma Cells In Vitro and In Vivo
Authors: Kim Jin-Soo , Kim Mi Young , Hong Sungyoul
Published: September 2023

The incidence of HER2 amplification in advanced gastroesophageal adenocarcinoma (GC) reportedly ranges between 10% and 20%, depending on the population studied and the geographical region. Trastuzumab (Tmab) is the standard treatment for GCs with HER2 amplification. Metformin, a widely used antidiabetic drug, is an activator of AMP kinase that can affect the mTOR signaling pathway. The following GC cells were evaluated: HER2+ NCI-N87, YCC-19, YCC-38, OE19, OE33, and HER2- AGS. The effects of Tmab and metformin on these cell lines were assessed as single agents and in combination using cell viability assays, Western blotting, and xenograft models. Metformin induced phosphorylation of AMP kinase in all tested GC cells and dephosphorylation of mTOR in Tmab-sensitive GC cells. We observed that treatment with Tmab in combination with metformin induced a significant decrease in the number of colonies formed on soft agar by N87, YCC-19, YCC-38, and OE19 cells (88%, 95%, 73%, and 98%, respectively), in comparison to the number formed by control cells or cells in the single-treatment groups. No growth inhibition was detected in OE33 cells treated with Tmab alone. Combination with metformin resulted in decreased phosphorylation of HER2 and its downstream targets, AKT and ERK, in Tmab-sensitive HER2+ cells. Phospho-receptor tyrosine kinase (RTK) arrays were used to profile the phospho-proteome, which demonstrated a synergistic decrease in phosphorylation of EGFR, HER2, and HER3. Furthermore, the combination of Tmab and metformin exhibited enhanced antitumor effects in a xenograft model. Collectively, these data suggest that Tmab and metformin act synergistically in HER2+ GC cells. Since metformin is widely used and relatively non-toxic, its addition to the therapeutic regimen along with Tmab could enhance the clinical efficacy in patients with HER2+ GC.
Minimally-Invasive Secondary Cytoreduction in Recurrent Ovarian Cancer
Authors: Certelli Camilla , Russo Silvio Andrea , Palmieri Luca , Foresta Aniello , Pedone Anchora Luigi , Vargiu Virginia , Santullo Francesco , Fagotti Anna , Scambia Giovanni , Gallotta Valerio
Published: September 2023

The role of secondary cytoreductive surgery (SCS) in the treatment of recurrent ovarian cancer (ROC) has been widely increased in recent years, especially in trying to improve the quality of life of these patients by utilising a minimally-invasive (MI) approach. However, surgery in previously-treated patients may be challenging, and patient selection and surgical planning are crucial. Unfortunately, at the moment, validated criteria to select patients for MI-SCS are not reported, and no predictors of its feasibility are currently available, probably due to the vast heterogeneity of recurrence patterns. The aim of this narrative review is to describe the role of secondary cytoreductive surgery and, in particular, minimally-invasive procedures, in ROC, analyzing patient selection, outcomes, criticisms, and future perspectives.
Dual Functions of T Lymphocytes in Breast Carcinoma: From Immune Protection to Orchestrating Tumor Progression and Metastasis
Authors: Zareinejad Mohammadrasul , Mehdipour Fereshteh , Roshan-Zamir Mina , Faghih Zahra , Ghaderi Abbas
Published: September 2023

Breast cancer (BC) is the most common cancer type in women and the second leading cause of death. Despite recent advances, the mortality rate of BC is still high, highlighting a need to develop new treatment strategies including the modulation of the immune system and immunotherapies. In this regard, understanding the complex function of the involved immune cells and their crosstalk with tumor cells is of great importance. T-cells are recognized as the most important cells in the tumor microenvironment and are divided into several subtypes including helper, cytotoxic, and regulatory T-cells according to their transcription factors, markers, and functions. This article attempts to provide a comprehensive review of the role of T-cell subsets in the prognosis and treatment of patients with BC, and crosstalk between tumor cells and T-cells. The literature overwhelmingly contains controversial findings mainly due to the plasticity of T-cell subsets within the inflammatory conditions and the use of different panels for their phenotyping. However, investigating the role of T-cells in BC immunity depends on a variety of factors including tumor types or subtypes, the stage of the disease, the localization of the cells in the tumor tissue and the presence of different cells or cytokines.
Examining the Effect of ALK and EGFR Mutations on Survival Outcomes in Surgical Lung Brain Metastasis Patients
Authors: Mannam Sneha Sai , Bray David P. , Nwagwu Chibueze D. , Zhong Jim , Shu Hui-Kuo , Eaton Bree , Sudmeier Lisa , Goyal Subir , Deibert Christopher , Nduom Edjah K. , Olson Jeffrey , Hoang Kimberly B.
Published: September 2023

In the context of the post-genomic era, where targeted oncological therapies like monoclonal antibodies (mAbs) and tyrosine-kinase inhibitors (TKIs) are gaining prominence, this study investigates whether these therapies can enhance survival for lung carcinoma patients with specific genetic mutations—EGFR-amplified and ALK-rearranged mutations. Prior to this study, no research series had explored how these mutations influence patient survival in cases of surgical lung brain metastases (BMs). Through a multi-site retrospective analysis, the study examined patients who underwent surgical resection for BM arising from primary lung cancer at Emory University Hospital from January 2012 to May 2022. The mutational statuses were determined from brain tissue biopsies, and survival analyses were conducted. Results from 95 patients (average age: 65.8 ± 10.6) showed that while 6.3% had anaplastic lymphoma kinase (ALK)-rearranged mutations and 20.0% had epidermal growth factor receptor (EGFR)-amplified mutations—with 9.5% receiving second-line therapies—these mutations did not significantly correlate with overall survival. Although the sample size of patients receiving targeted therapies was limited, the study highlighted improved overall survival and progression-free survival rates compared to earlier trials, suggesting advancements in systemic lung metastasis treatment. The study suggests that as more targeted therapies emerge, the prospects for increased overall survival and progression-free survival in lung brain metastasis patients will likely improve.
PAK1 and Therapy Resistance in Melanoma
Authors: Kichina Julia V. , Maslov Alexei , Kandel Eugene S.
Published: September 2023

Malignant melanoma claims more lives than any other skin malignancy. While primary melanomas are usually cured via surgical excision, the metastatic form of the disease portents a poor prognosis. Decades of intense research has yielded an extensive armamentarium of anti-melanoma therapies, ranging from genotoxic chemo- and radiotherapies to targeted interventions in specific signaling pathways and immune functions. Unfortunately, even the most up-to-date embodiments of these therapies are not curative for the majority of metastatic melanoma patients, and the need to improve their efficacy is widely recognized. Here, we review the reports that implicate p21-regulated kinase 1 (PAK1) and PAK1-related pathways in the response of melanoma to various therapeutic modalities. Ample data suggest that PAK1 may decrease cell sensitivity to programmed cell death, provide additional stimulation to growth-promoting molecular pathways, and contribute to the creation of an immunosuppressive tumor microenvironment. Accordingly, there is mounting evidence that the concomitant inhibition of PAK1 enhances the potency of various anti-melanoma regimens. Overall, the available information suggests that a safe and effective inhibition of PAK1-dependent molecular processes would enhance the potency of the currently available anti-melanoma treatments, although considerable challenges in implementing such strategies still exist.
Assessment of Efficiency and Anilox-Roll Condition after Ultrasonic Cleaning
Authors: Przybysz Kamila , Lipkiewicz Aneta , Małachowska Edyta , Dubowik Marcin , Przybysz Piotr
Published: September 2023

In the flexographic printing industry, anilox rolls play a pivotal role in determining ink usage. These rolls are characterized by anilox cells, which transfer ink to the final printed material. However, these rolls face wear and potential damage during their operational life, largely due to improper cleaning or debris accumulation in the ink duct. Such contamination compromises the ink capacity, impacting print quality. With the industry’s need for consistent and high-quality prints, there is a growing emphasis on the development and consistent implementation of optimal anilox-roll operation methodologies. One cleaning method gaining traction is ultrasonic cleaning. This method employs ultrasonic waves in conjunction with a cleaning agent, providing a quick, efficient, and environmentally conscious cleaning alternative. Yet, there is limited scientific data on the actual condition of anilox rolls after ultrasonic cleaning. In this study, the surface of anilox rolls post-ultrasonic-cleaning was comprehensively examined using microscopic analysis. This assessment provided insights into the method’s efficacy and potential for causing roll damage. The results showed that post-printing, rolls lost approximately 20% of their ink capacity, and ultrasonic cleaning effectively restored the ink capacity of the undamaged rolls. However, for rolls with pre-existing damage, the ultrasonic cleaning process exacerbated the damages, leading to complete delamination in some instances. This study underscores the potential of ultrasonic cleaning in restoring anilox-roll efficiency but also highlights the need for caution with damaged rolls.
Study on the Influence of Pre-Formed Phase on Accelerating Bainitic Transformation
Authors: Long Xiaoyan , Zhang Yu , Sun Dongyun , Yin Dongxin , Liu Wei , Zhang Zhen , Zhang Fucheng , Li Yanguo
Published: September 2023

Bainitic transformation goes through three stages: incubation period, nucleation, and growth. The long transformation time is not conducive to industrial production, which restricts its development. Therefore, research on accelerating bainitic transformation is based on the situation of energy saving and efficiency saving. The methods to accelerate bainitic transformation include the control of alloy elements, heat treatment control, etc. This paper focuses on the influence of the pre-formed phase on the kinetics of accelerated bainite transformation. Combined with existing research and experiments, it clarifies the influence of pre-formed ferrite, pre-formed martensite, and precipitated second-phase particles on the kinetics of bainitic transformation. Moreover, it clarifies the characteristics of bainitic transformation in terms of microstructure characterization.
Advanced Analyses of Heating Elements Manufactured by an Optimized Arc Spraying Process
Authors: Hauer Michél , Ripsch Benjamin , Gericke Andreas , Krömmer Werner , Henkel Knuth-Michael
Published: September 2023

Heating elements in the automotive industry are currently produced by several thermal spray processes and materials. However, simpler spraying technologies such as arc spraying are investigated regarding technological suitability as a cost-effective alternative to plasma spraying in the production process of these components. Thus, several mixtures and combinations of alternative pressurizing gases and further modifications of an arc spray process were examined in this study. Consequently, coatings based on NiCr were produced, since this alloy is typical for heating elements. Coating properties were investigated by SEM, EDS, and resistivity measurements. The results demonstrate reduced oxygen content and improved morphology compared with the industrially used plasma-sprayed coatings. Additionally, the improved microstructure affects the surface quality and specific resistivity of the coatings positively. This allowed for laser texturing the arc-sprayed coatings successfully. It must be considered a drawback, though, that cracks partially appeared in the underlying coatings. In contrast, the temperature coefficients of resistance and the resistivities of the heating elements were superior to the conventional coatings, which can lay the foundation for a future industrial application. To further investigate this and to minimize the influence of potential sample preparation issues on the analysis results, different methods of cross-sectioning, i.e., in detail hot mounting, cold mounting, and ion beam polishing, were evaluated.
Effect of the Injection Structure on Gas Velocity Distribution in a 3D Vertical Oven
Authors: Zhou Qiucheng , Yang Zhanyu , Zheng Changsong , Wei Liping , Li Dong , Fan Xiaoyong
Published: September 2023

Gas injection structures were designed for a vertical oven to improve the gas–solid flow countercurrent structure. This work measured the wall temperature distribution of the vertical oven to reflect gas velocity distribution, and simulated the basic gas–solid flow field. The effects of the number of gas orifice layers and the injection angle on the gas velocity distribution were examined. The results showed that number of gas injection layers had a significant effect on the gas velocity distribution in the lower zone. Compared with the distributions with one or three injection layers, two injection layers produce more uniform gas flow. A small particle size of 6–15 mm increased the bed resistance and solid fraction standard deviation. A nozzle angle of 45° was conducive to increase the gas velocity in the upper zone and forming a more uniform gas distribution.
Room-Temperature, Nanoscale Multiferroic Pb(Fe0.5Ta0.5)1−x(Zr0.53Ti0.47)xO3 (x = 0.2, 0.3) Thin Films Grown via the Pulsed Laser Deposition Technique
Authors: Sanchez Dilsom A. , Mishra Karuna Kara , Saha Sujoy , Srinivasan Gopalan , Katiyar Ram S.
Published: September 2023

Multiferroic materials capable of robust magnetoelectric coupling at room temperature are currently being explored for their possible multifunctional device applications. Highly (100)-oriented Pb(Fe0.5Ta0.5)x(Zr0.53Ti0.47)1−x (PZTFTx) thin films (x = 0.2 and 0.3) with a thickness of about 300 nm were grown on La0.67Sr0.33CoO3 (LSCO)-buffered MgO 100-oriented substrates via the pulsed laser deposition method. An analysis of their X-ray diffraction patterns suggests the stabilization of the orthorhombic phase in the thin films at room temperature. Dielectric spectroscopic measurements of the metal–insulator–metal (Pt/PZTFTx/LSCO) thin-film capacitors as a function of temperature revealed a diffuse ferroelectric-to-paraelectric phase transition around Tm ~520 and 560 K for the x = 0.2 and 0.3 thin films, respectively. Well-saturated electrical hysteresis loops with large remanent (Pr) and saturation (Ps) polarizations were observed in these capacitors, which indicates the establishment of intrinsic ferroelectric ordering in the thin films at room temperature. These thin films retained ferromagnetic/ferrimagnetic ordering up to 300 K and showed saturation magnetization values of 8.3 (x = 0.2) and 6.1 (x = 0.3) emu/cm3 at room temperature. The magnetoelectric coupling constants of 2040 mV/cmOe (x = 0.2) and 850 mV/cmOe (x = 0.3), respectively, were obtained at an in-plane bias field at room temperature. The present study demonstrates that PZTFTx thin films are multiferroic at room temperature with large magnetoelectric couplings, and these materials may be suitable for use in magnetic sensors and spintronic device applications.
Effect of Samarium on the Properties of Hot-Extruded Mg–Y–Gd–Zr Alloys
Authors: Lukyanova Elena , Martynenko Natalia , Rybalchenko Olga , Dobatkina Tatiana , Tarytina Irina , Tabachkova Natalia , Rybalchenko Georgy , Andreeva Nadezhda , Dobatkin Sergey
Published: September 2023

The effect of such an additional promising alloying element as samarium on hot-extruded Mg–Y–Gd–Zr alloys is investigated. The microstructure, kinetics of aging during the decomposition of a supersaturated Mg solid solution, and the mechanical properties of the alloys are studied. The differences of the recrystallization processes that occur in hot-extruded alloys with various contents of samarium (0, 1.7, 2.5%) are demonstrated. After hot extrusion, Mg–Y–Gd–Zr and Mg–Y–Gd–Sm–Zr alloys are additionally hardened during aging due to the decomposition of a supersaturated Mg solid solution. At the same time, samarium changes the nature of this hardening. The alloys with samarium are hardened faster, and the maximum hardness is achieved with shorter aging exposures. The mechanical properties of hot-extruded Mg–Y–Gd–Zr alloys with samarium addition are determined at room and elevated up to 300 °C temperatures. The efficiency and expediency of using samarium both as a separate alloying element and as a partial replacement of more expensive rare-earth elements in alloys with yttrium and gadolinium are shown.
Comparing the Effectiveness of Biodiversity Conservation across Different Regions at County Scale
Authors: Dong Kaikai , Chen Ziqi , Li Ying , Hou Guanglei , Liu Zhaoli
Published: September 2023

The central government of China encourages enthusiasm for biodiversity conservation by implementing a transfer payment policy targeted at Biodiversity National Key Ecological Functional Areas at the county scale. Biodiversity National Key Ecological Functional Areas are types of PAs that were designated by the State Council of China for the implementation of biodiversity conservation. However, regional comparative assessment results of biodiversity conservation effectiveness in different county-level administrative units are still lacking. In this study, we developed a reference condition index to represent the ecological background, and we then constructed a conservation effectiveness index to compare the conservation efforts among 131 counties in seven Biodiversity National Key Ecological Functional Areas. The results showed the following: (1) The biological background could be well reflected by the reference condition index. The Tropical Rainforest Ecological Function Area in Mountain Areas in the Middle of Hainan Island had the best biological background, while the Desert Ecological Function Area on the Northwest Qiangtang Plateau had the worst. (2) The biodiversity conservation effectiveness of the Desert Ecological Function Area on the Northwest Qiangtang Plateau was the best, and that of the Wetland Ecological Function Area of the Three River Plain was worst. (3) Among the 131 counties, Taibai County in the Biodiversity Ecological Function Area of Qinba Mountain performed best, while Fujin City in the Wetland Ecological Function Area of the Three River Plain performed worst. Our study could provide valuable insights for the transfer payment. Meanwhile, it can also supply a scientific reference for the management of Biodiversity National Key Ecological Functional Areas to enhance biodiversity.
Bioactive Components of Myracrodruon urundeuva against SARS-CoV-2: A Computational Study
Authors: Alves Sabrina Kelly Silva , Sousa Cássio Silva , Viana Edilanne Katrine Amparo , Souza Hellen Cris Araújo , Souza Maycon Douglas Araújo , Ribeiro Arthur Serejo Neves , Vale Vanessa de Sousa do , Islam Muhammad Torequl , Araújo Joabe Lima , Rocha Jefferson Almeida
Published: September 2023

SARS-CoV-2 (severe acute respiratory distress syndrome coronavirus 2) is the causative agent for the novel coronavirus disease 2019 (COVID-19). It raises serious biosecurity questions due to its high contagious potential, thereby triggering rapid and efficient responses by the scientific community to take necessary actions against viral infections. Cumulative scientific evidence suggests that natural products remain one of the main sources for pharmaceutical consumption. It is due to their wide chemical diversity that they are able to fight against almost all kinds of diseases and disorders in humans and other animals. Knowing the overall facts, this study was carried out to investigate the chemical interactions between the active constituents of a promising medicinal plant, Myracrodruon urundeuva, and some specific proteins of SARS-CoV-2. For this, we used molecular docking to predict the most appropriate orientation by binding a molecule (a ligand) to its receptor (a protein). The best results were evaluated by screening their pharmacokinetic properties using the online tool pkCSM. Findings suggest that among 44 chemical compounds of M. urundeuva, agathisflavone, which is abundantly present in its leaf, exhibited excellent molecular affinity (−9.3 to −9.7 kcal.mol−1) with three functional proteins, namely, Spike, MPro, and RBD of SARS-CoV-2. In conclusion, M. urundeuva might be a good source of antiviral agents. Further studies are required to elucidate the exact mechanism of action of the bioactive compounds of M. urundeuva acting against SARS-CoV-2.
Hashimoto’s Thyroiditis and Papillary Thyroid Carcinoma: A Follow-Up Study in Patients with Absence of Aggressive Risk Factors at the Surgery of the Primary Tumor
Authors: Marongiu Andrea , Nuvoli Susanna , De Vito Andrea , Vargiu Sonia , Spanu Angela , Madeddu Giuseppe
Published: September 2023

Hashimoto’s thyroiditis (HT) is often associated with papillary thyroid carcinoma (PC); it is still a matter of controversy whether the behavior of carcinoma is more aggressive or not. During the follow-up, we retrospectively enrolled 97 patients with PC/HT after thyroidectomy without risk factors at the surgery of the primary tumor, such as multifocality/multicentricity, extrathyroid tumor extension, vascular invasion, neck and distant metastases, and aggressive histological variants. HT diagnosis was confirmed by histology and serum thyroid antibodies. Tumor size was ≤10 mm in 64 cases (microcarcinomas); 206 matched PC patients after thyroidectomy without HT and risk factors were enrolled as controls, totaling 122 microcarcinomas. During follow-up, metastases occurred in 15/97 (15.5%) PC/HT cases, eight microcarcinomas, and in 16/206 (7.8%) without HT, eight microcarcinomas (p = 0.04). Considering both PC/HT and PC patients without HT who developed metastases, univariate analysis showed an increased risk of metastases in patients with HT coexistence, OR: 2.17 (95% CI 1.03–4.60) p = 0.043. Disease-free survival (DFS) was significantly (p = 0.0253) shorter in PC/HT than in the controls. The present study seems to demonstrate that HT is not a cancer protective factor in PC patients given the less favorable outcomes and significantly shorter DFS. HT may also represent an independent recurrence predictor without other risk factors.
Update on Myocarditis: From Etiology and Clinical Picture to Modern Diagnostics and Methods of Treatment
Authors: Lasica Ratko , Djukanovic Lazar , Savic Lidija , Krljanac Gordana , Zdravkovic Marija , Ristic Marko , Lasica Andjelka , Asanin Milika , Ristic Arsen
Published: September 2023

Although the frequency of myocarditis in the general population is very difficult to accurately determine due to the large number of asymptomatic cases, the incidence of this disease is increasing significantly due to better defined criteria for diagnosis and the development of modern diagnostic methods. The multitude of different etiological factors, the diversity of the clinical picture, and the variability of the diagnostic findings make this disease often demanding both for the selection of the diagnostic modality and for the proper therapeutic approach. The previously known most common viral etiology of this disease is today overshadowed by new findings based on immune-mediated processes, associated with diseases that in their natural course can lead to myocardial involvement, as well as the iatrogenic cause of myocarditis, which is due to use of immune checkpoint inhibitors in the treatment of cancer patients. Suspecting that a patient with polymorphic and non-specific clinical signs and symptoms, such as changes in ECG and echocardiography readings, has myocarditis is the starting point in the diagnostic algorithm. Cardio magnetic resonance imaging is non-invasive and is the gold standard for diagnosis and clinical follow-up of these patients. Endomyocardial biopsy as an invasive method is the diagnostic choice in life-threatening cases with suspicion of fulminant myocarditis where the diagnosis has not yet established or there is no adequate response to the applied therapeutic regimen. The treatment of myocarditis is increasingly demanding and includes conservative methods of treating heart failure, immunomodulatory and immunospressive therapy, methods of mechanical circulatory support, and heart transplantation. The goal of developing new diagnostic and therapeutic methods is to reduce mortality from this complex disease, which is still high.
PTOLEMI: Personalized Cancer Treatment through Machine Learning-Enabled Image Analysis of Microfluidic Assays
Authors: Moerdler Bernard , Krasner Matan , Orenbuch Elazar , Grad Avi , Friedman Benjamin , Graber Eliezer , Barbiro-Michaely Efrat , Gerber Doron
Published: September 2023

Contemporary personalized cancer diagnostic approaches encounter multiple challenges. The presence of cellular and molecular heterogeneity in patient samples introduces complexities to analysis protocols. Conventional analyses are manual, reliant on expert personnel, time-intensive, and financially burdensome. The copious data amassed for subsequent analysis strains the system, obstructing real-time diagnostics at the “point of care” and impeding prompt intervention. This study introduces PTOLEMI: Python-based Tensor Oncological Locator Examining Microfluidic Instruments. PTOLEMI stands out as a specialized system designed for high-throughput image analysis, particularly in the realm of microfluidic assays. Utilizing a blend of machine learning algorithms, PTOLEMI can process large datasets rapidly and with high accuracy, making it feasible for point-of-care diagnostics. Furthermore, its advanced analytics capabilities facilitate a more granular understanding of cellular dynamics, thereby allowing for more targeted and effective treatment options. Leveraging cutting-edge AI algorithms, PTOLEMI rapidly and accurately discriminates between cell viability and distinct cell types within biopsy samples. The diagnostic process becomes automated, swift, precise, and resource-efficient, rendering it well-suited for point-of-care requisites. By employing PTOLEMI alongside a microfluidic cell culture chip, physicians can attain personalized diagnostic and therapeutic insights. This paper elucidates the evolution of PTOLEMI and showcases its prowess in analyzing cancer patient samples within a microfluidic apparatus. While the integration of machine learning tools into biomedical domains is undoubtedly in progress, this study’s innovation lies in the fusion of PTOLEMI with a microfluidic platform—an integrated, rapid, and independent framework for personalized drug screening-based clinical decision-making.
Efficient Focus Autoencoders for Fast Autonomous Flight in Intricate Wild Scenarios
Authors: Hu Kaiyu , Li Huanlin , Zhuang Jiafan , Hao Zhifeng , Fan Zhun
Published: September 2023

The autonomous navigation of aerial robots in unknown and complex outdoor environments is a challenging problem that typically requires planners to generate collision-free trajectories based on human expert rules for fast navigation. Presently, aerial robots suffer from high latency in acquiring environmental information, which limits the control strategies that the vehicle can implement. In this study, we proposed the SAC_FAE algorithm for high-speed navigation in complex environments using deep reinforcement learning (DRL) policies. Our approach consisted of a soft actor–critic (SAC) algorithm and a focus autoencoder (FAE). Our end-to-end DRL navigation policy enabled a flying robot to efficiently accomplish navigation tasks without prior map information by relying solely on the front-end depth frames and its own pose information. The proposed algorithm outperformed existing trajectory-based optimization approaches at flight speeds exceeding 3 m/s in multiple testing environments, which demonstrates its effectiveness and efficiency.
On Joint Optimization of UAV-Assisted Covert Communication Systems with NOMA for Hydropower Internet of Things
Authors: Le Zhenchun , Xu Qing , Wang Yining , Hao Guowen , Pan Weifeng , Sun Yanlin , Qian Yuwen
Published: September 2023

The intelligent terminals deployed in hydropower IoT can quickly sense the status of hydropower equipment, thus improving the efficiency of system control and operation. However, communication security between the base station and intelligent terminals challenges the IoT hydropower plant. In this paper, we propose a UAV-assisted covert communication system (CCS), where a UAV acts as the base station to provide communication service to ground terminals monitored by malicious users. To improve access effectiveness, we adopt non-orthogonal multiple access (NOMA) for intelligent terminals to access the hydropower IoT. Since two devices can synchronously access the communication system with the NOMA scheme, we select one terminal to receive covert messages and the other to interfere with the malicious users to detect confidential communications. To maximize the covert rate, we formulate the optimization problem that jointly optimizes the transmit power, the altitude of the UAV, and trajectory under the constraints of covertness and the finite length of the transmission message block. Additionally, we transform the optimization problem into a geometric planning one, which is solved by a developed sequential geometric planning (SGP) approximation algorithm. Simulation results show the proposed algorithm can improve the covert rate compared to the traditional methods.