bluuebunny/crossref_metadata_2025 huggingface dataset:
Bibliometric analysis of tumor necrosis factor in post-stroke neuroinflammation from 2003 to 2021
Authors: Zhao Yang , Zhu Qihan , Bi Chen , Yuan Jichao , Chen Yujie , Hu Xiaofei
Published: October 2022

Objective

Tumor necrosis factor (TNF), a crucial cytokine, has important research value in post-stroke neuroinflammation (PSN). We analyzed the studies that have been conducted in this area and used bibliometric methods to predict research hotspots and identify trends regarding TNF in PSN.

Methods

Publications were accessed at the Science Citation Index Expanded 1975-2021 (SCI expanded), Web of Science Core Collection (WoSCC), on May 1, 2022. Additionally, software such as CiteSpace and VOSviewer were utilized for bibliometric analyses.

Results

In total, 1391 original articles and reviews on TNF in PSN published from 2003 to 2021 were identified. An upward trend was observed in the number of publications on TNF in PSN. These publications were primarily from 57 countries and 1446 institutions, led by China and the United States with China leading the number of publications (NP) and the US with the number of citations (NC). The League of European Research Universities (LERU) and Journal of Neuroinflammation, respectively were the most prolific branches and journals. Zhang, John H. published the most papers and Finsen, Bente had the most cited papers. One paper by Kettenmann, H. published in 2011 reached the highest level of Global Citation Score (GCS). The keyword co-occurrence and reference co-citation analyses suggest that poststroke therapy and potential mechanistic pathways are important topics related to PSN in recent years. Reference burst detection suggests new burst hotspots after 2015, focusing on pathway modulation and discovery of therapeutic targets, suggesting a substantial development in the study of TNF in PSN research.

Conclusion

The present bibliometric analysis shows a continuous trend of increasing literature related to TNF in PSN, and shows that TNF plays an important role in PSN involves multiple immune mechanisms and may contribute as a potential target for neuroprotective therapeutics after stroke. Prior to 2011, most of the research was focused on discovering the specific role of TNF in PSN, and in recent years studies have mainly targeted the exploration of the signaling pathways. Future research prospects may lie in finding key therapeutic targets in pathway of TNF in PSN.
Valorization of the chemical diversity of the tropical red seaweeds Acanthophora and Kappaphycus and their applications in aquaculture: A review
Authors: Guillén Paúl O. , Motti Pierfrancesco , Mangelinckx Sven , De Clerck Olivier , Bossier Peter , Van Den Hende Sofie
Published: October 2022

The role that seaweeds play as primary producers and ecosystems engineers in marine coastal ecosystems is widely acknowledged. Seaweeds, however, are also important drivers in the development of the blue bioeconomy due to their vast diversity of unique chemicals with a broad range of industrial and biotechnological applications. In tropical regions, seaweed production has been focused on a few species only, because of their hydrocolloids used in the food industry. There is a strong need to identify new applications of red seaweed species in other sectors such as aquaculture. Therefore, to diversify the culture of red seaweeds, more tropical species need to be investigated for their chemical composition and potential application in aquaculture, and then, to develop a method for a sustainable cultivation of new seaweed candidates and enhance their economic potential. Based on this context, we analyze the potential value of the red edible seaweed Acanthophora spp., an under-valued seaweed species which is naturally abundant in tropical countries, and Kappaphycus spp., a commercially valuable seaweed commonly used for polysaccharide extraction. The vast chemical diversity of seaweeds (polysaccharides, phytohormones, amino acids, and pigments) has led to research on a wide range of applications in aquaculture, including pathogen control, immunostimulant, antioxidant, bioremediation, feed, UV protectants, increase in seafood shelf life, animal colorant, and growth regulator for microalga culture. This review hopes to stimulate the interest among seaweed researchers to investigate other local seaweed species and seek greater added value of their biomass and chemical compounds and their applications in the aquaculture sector. Additionally, this information will help stakeholders to benefit from these two red seaweeds by contributing to the diversification of the blue bioeconomy in tropical countries.
Effects of probiotic supplements on cognition, anxiety, and physical activity in subjects with mild and moderate Alzheimer’s disease: A randomized, double-blind, and placebo-controlled study
Authors: Akhgarjand Camellia , Vahabi Zahra , Shab-Bidar Sakineh , Etesam Farnaz , Djafarian Kurosh
Published: October 2022

Probiotics have been suggested as an effective adjuvant treatment for Alzheimer’s disease (AD) due to their modulating effect on the gut microbiota, which may affect the gut-brain axis. Therefore, we aimed to evaluate the effects of two different single-strain probiotics on cognition, physical activity, and anxiety in subjects with mild and moderate AD. Eligible patients (n = 90) with AD were randomly assigned to either of two interventions [Lactobacillus rhamnosus HA-114 (1015 CFU) or Bifidobacterium longum R0175 (1015 CFU)] or placebo group, receiving probiotic supplement twice daily for 12 weeks. The primary outcome of the study was cognitive function measured by using the two tests, namely, the Mini-Mental State Examination (MMSE) and the categorical verbal fluency test (CFT). Secondary outcomes included a performance in Activities of Daily Living (ADL), the Lawton Instrumental Activities of Daily Living (IADL) scale, and the Generalized Anxiety Disorder (GAD-7) scale. Linear mixed-effect models were used to investigate the independent effects of probiotics on clinical outcomes. After 12 weeks, MMSE significantly improved cognition (PInteraction < 0.0001), with post hoc comparisons identifying significantly more improvement in the B. longum intervention group (differences: 4.86, 95% CI: 3.91–5.81; P < 0.0001) compared with both the placebo and L. rhamnosus intervention groups (differences: 4.06, 95% CI: 3.11–5.01; P < 0.0001). There was no significant difference between the two intervention groups (differences: −0.8, 95% CI: −1.74 to 0.14; P = 0.09). In conclusion, this trial demonstrated that 12-week probiotic supplementation compared with placebo had beneficial effects on the cognition status of patients with AD.
Robust quasi-uniform surface meshing of neuronal morphology using line skeleton-based progressive convolution approximation
Authors: Zhu Xiaoqiang , Liu Xiaomei , Liu Sihu , Shen Yalan , You Lihua , Wang Yimin
Published: October 2022

Creating high-quality polygonal meshes which represent the membrane surface of neurons for both visualization and numerical simulation purposes is an important yet nontrivial task, due to their irregular and complicated structures. In this paper, we develop a novel approach of constructing a watertight 3D mesh from the abstract point-and-diameter representation of the given neuronal morphology. The membrane shape of the neuron is reconstructed by progressively deforming an initial sphere with the guidance of the neuronal skeleton, which can be regarded as a digital sculpting process. To efficiently deform the surface, a local mapping is adopted to simulate the animation skinning. As a result, only the vertices within the region of influence (ROI) of the current skeletal position need to be updated. The ROI is determined based on the finite-support convolution kernel, which is convolved along the line skeleton of the neuron to generate a potential field that further smooths the overall surface at both unidirectional and bifurcating regions. Meanwhile, the mesh quality during the entire evolution is always guaranteed by a set of quasi-uniform rules, which split excessively long edges, collapse undersized ones, and adjust vertices within the tangent plane to produce regular triangles. Additionally, the local vertices density on the result mesh is decided by the radius and curvature of neurites to achieve adaptiveness.
The investigation of construction and clinical application of image recognition technology assisted bronchoscopy diagnostic model of lung cancer
Authors: Deng Yihong , Chen Yuan , Xie Lihua , Wang Liansheng , Zhan Juan
Published: October 2022

Background

The incidence and mortality of lung cancer ranks first in China. Bronchoscopy is one of the most common diagnostic methods for lung cancer. In recent years, image recognition technology(IRT) has been more and more widely studied and applied in the medical field. We developed a diagnostic model of lung cancer under bronchoscopy based on deep learning method and tried to classify pathological types.

Methods

A total of 2238 lesion images were collected retrospectively from 666 cases of lung cancer diagnosed by pathology in the bronchoscopy center of the Third Xiangya Hospital from Oct.01 2017 to Dec.31 2020 and 152 benign cases from Jun.01 2015 to Dec.31 2020. The benign and malignant images were divided into training, verification and test set according to 7:1:2 respectively. The model was trained and tested based on deep learning method. We also tried to classify different pathological types of lung cancer using the model. Furthermore, 9 clinicians with different experience were invited to diagnose the same test images and the results were compared with the model.

Results

The diagnostic model took a total of 30s to diagnose 467 test images. The overall accuracy, sensitivity, specificity and area under curve (AUC) of the model to differentiate benign and malignant lesions were 0.951, 0.978, 0.833 and 0.940, which were equivalent to the judgment results of 2 doctors in the senior group and higher than those of other doctors. In the classification of squamous cell carcinoma (SCC) and adenocarcinoma (AC), the overall accuracy was 0.745, including 0.790 for SCC, 0.667 for AC and AUC was 0.728.

Conclusion

The performance of our diagnostic model to distinguish benign and malignant lesions in bronchoscopy is roughly the same as that of experienced clinicians and the efficiency is much higher than manually. Our study verifies the possibility of applying IRT in diagnosis of lung cancer during white light bronchoscopy.
The impact of hysterectomy on oncological outcomes in postmenopausal patients with borderline ovarian tumors: A multicenter retrospective study
Authors: Raimondo Diego , Raffone Antonio , Scambia Giovanni , Maletta Manuela , Lenzi Jacopo , Restaino Stefano , Mascilini Floriana , Trozzi Rita , Mauro Jessica , Travaglino Antonio , Driul Lorenza , Casadio Paolo , Mollo Antonio , Fagotti Anna , Vizzielli Giuseppe , Seracchioli Renato
Published: October 2022

Data about the oncological outcomes in women with borderline ovarian tumor (BOT) undergoing uterine-sparing surgery without ovarian preservation are poor. We aimed to assess the oncological outcomes in women with BOT undergoing uterine-sparing surgery without ovarian preservation. A multi-center observational retrospective cohort study was performed including all consecutive postmenopausal patients who underwent surgical treatment for BOT at three tertiary level referral centers for gynecologic oncology from January 2005 to December 2016. Patients were divided into two groups for comparisons: patients undergoing hysterectomy (hysterectomy group) and patients undergoing uterine-sparing surgery (no hysterectomy group). Study outcomes were disease-free survival (DFS), overall survival (OS), disease-specific survival (DSS) and surgical complications rate. Ninety-eight patients were included: 44 in the hysterectomy group and 54 in the no hysterectomy group. The 5- and 10-year DFS rates were 97.7% (95% CI: 84.9–99.7) and 92.3% (95% CI: 69.7–98.2), in the hysterectomy group, and 86.8% (95% CI: 74.3–93.5) and 86.8% (95% CI: 74.3–93.5), in the no hysterectomy group, respectively, without significant differences (p=0.16). Hazard ratio for DFS was 0.26 (95% CI: 0.06–1.68) for the hysterectomy group. The 5- and 10-year OS rates were 100.0% (95% CI: -) and 100.0% (95% CI: -), in the hysterectomy group, and 98.2% (95% CI: 87.6–99.7) and 94.4% (95% CI: 77.7–98.7), in the no hysterectomy group, respectively, without significant differences (p=0.23). No significant difference in complication rate was reported among the groups (p=0.48). As hysterectomy appears to not impact survival outcomes of women with BOT, it might be avoided in the surgical staging.
Circulating tumor DNA detection in MRD assessment and diagnosis and treatment of non-small cell lung cancer
Authors: Fang Xiaoxu , Yu Shaokun , Jiang Yingying , Xiang Yan , Lu Kaihua
Published: October 2022

Circulating tumor DNA (ctDNA) has contributed immensely to the management of hematologic malignancy and is now considered a valuable detection tool for solid tumors. ctDNA can reflect the real-time tumor burden and be utilized for analyzing specific cancer mutations via liquid biopsy which is a non-invasive procedure that can be used with a relatively high frequency. Thus, many clinicians use ctDNA to assess minimal residual disease (MRD) and it serves as a prognostic and predictive biomarker for cancer therapy, especially for non-small cell lung cancer (NSCLC). Advanced methods have been developed to detect ctDNA, and recent clinical trials have shown the rationality and feasibility of ctDNA for identifying mutations and guiding treatments in NSCLC. Here, we have reviewed recently developed ctDNA detection methods and the importance of sequence analyses of ctDNA in NSCLC.
Effectiveness of hypofractionated and normofractionated radiotherapy in a triple‐negative breast cancer model
Authors: Grosche Sinja , Bogdanova Natalia V. , Ramachandran Dhanya , Lüdeking Marcus , Stemwedel Katharina , Christiansen Hans , Henkenberens Christoph , Merten Roland
Published: October 2022

Breast cancer (BC) is one of the most diagnosed malignant carcinomas in women with a triple-negative breast cancer (TNBC) phenotype being correlated with poorer prognosis. Fractionated radiotherapy (RT) is a central component of breast cancer management, especially after breast conserving surgery and is increasingly important for TNBC subtype prognosis. In recent years, moderately hypofractionated radiation schedules are established as a standard of care, but many professionals remain skeptical and are concerned about their efficiency and side effects. In the present study, two different triple-negative breast cancer cell lines, a non-malignant breast epithelial cell line and fibroblasts, were irradiated daily under normofractionated and hypofractionated schedules to evaluate the impact of different irradiation regimens on radiation-induced cell-biological effects. During the series of radiotherapy, proliferation, growth rate, double-strand DNA break-repair (DDR), cellular senescence, and cell survival were measured. Investigated normal and cancer cells differed in their responses and receptivity to different irradiation regimens, indicating cell line/cell type specificity of the effect. At the end of both therapy concepts, normal and malignant cells reach almost the same endpoint of cell count and proliferation inhibition, confirming the clinical observations in the follow-up at the cellular level. These result in cell lines closely replicating the irradiation schedules in clinical practice and, to some extent, contributing to the understanding of growth rate or remission of tumors and the development of fibrosis.
Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment
Authors: Rodriguez Nicole , Tessier Carmen A. , Mandhane Piushkumar J. , Pei Jacqueline , Simons Elinor , Moraes Theo J. , Turvey Stuart E. , Subbarao Padmaja , Kozyrskyj Anita L.
Published: October 2022

Introduction

Food sensitization is a first and strong indicator of immune deviation in the progression to other allergic conditions. Sensitization to food or other allergens and related inflammation during critical windows of infant development may adversely affect neurodevelopmental milestones. However, additional research is needed to test this association further.

Methods

Associations between atopic (any food or aeroallergen) or food sensitization (specific to egg, soybean, peanut, and milk) at age 1 year and neurodevelopment up to 2 years of age were evaluated in the national CHILD Cohort Study, with a secondary aim examining whether these associations were sex-specific. Food and atopic sensitization were assessed by skin prick tests (SPT) in 1-year-old infants, with neurodevelopment assessed using the cognitive, language, motor, and social-emotional subscales of the Bayley Scales of Infant Development (BSID-III) administered at 1 and 2 years of age.

Results

Atopic sensitization was present among 16.4% of infants, while 13.4% had food sensitizations. Only socioemotional scores reached statistical significance among the four BSID-III domains. Both atopic and food sensitization at 1 year of age was associated with lower social-emotional scores, independent of the infant's ethnicity. These findings were sex-specific and only observed among boys, among whom social-emotional scores were lowered by 5 points if atopic sensitization was present (−5.22 [95% CI: −9.96, −0.47], p = 0.03) or if food sensitization was present (−4.85 [95% CI: −9.82,0.11], p = 0.06). Similar results were observed using the standard SPT cut-off of ≥3 mm — for atopic sensitization (−5.17 [95% CI: −11.14, −0.80], p = 0.09) and for food sensitization (−4.61 [95% CI: −10.96, 1.74], p = 0.15).

Conclusion

In our study of term infants, we found an inverse, cross-sectional association between atopic and food sensitization status and social-emotional development scores in male children but not female children.
Macadamia germplasm and genomic database (MacadamiaGGD): A comprehensive platform for germplasm innovation and functional genomics in Macadamia
Authors: Wang Pan , Mo Yi , Wang Yi , Fei Yuchong , Huang Jianting , Ni Jun , Xu Zeng-Fu
Published: October 2022

As an important nut crop species, macadamia continues to gain increased amounts of attention worldwide. Nevertheless, with the vast increase in macadamia omic data, it is becoming difficult for researchers to effectively process and utilize the information. In this work, we developed the first integrated germplasm and genomic database for macadamia (MacadamiaGGD), which includes five genomes of four species; three chloroplast and mitochondrial genomes; genome annotations; transcriptomic data for three macadamia varieties, germplasm data for four species and 262 main varieties; nine genetic linkage maps; and 35 single-nucleotide polymorphisms (SNPs). The database serves as a valuable collection of simple sequence repeat (SSR) markers, including both markers that are based on macadamia genomic sequences and developed in this study and markers developed previously. MacadamiaGGD is also integrated with multiple bioinformatic tools, such as search, JBrowse, BLAST, primer designer, sequence fetch, enrichment analysis, multiple sequence alignment, genome alignment, and gene homology annotation, which allows users to conveniently analyze their data of interest. MacadamiaGGD is freely available online (http://MacadamiaGGD.net). We believe that the database and additional information of the SSR markers can help scientists better understand the genomic sequence information of macadamia and further facilitate molecular breeding efforts of this species.
Zinc biofortification of hydroponically grown basil: Stress physiological responses and impact on antioxidant secondary metabolites of genotypic variants
Authors: Ciriello Michele , Formisano Luigi , Kyriacou Marios , Soteriou Georgios A. , Graziani Giulia , De Pascale Stefania , Rouphael Youssef
Published: October 2022

Ocimum basilicum L. is an aromatic plant rich in bioactive metabolites beneficial to human health. The agronomic biofortification of basil with Zn could provide a practical and sustainable solution to address Zn deficiency in humans. Our research appraised the effects of biofortification implemented through nutrient solutions of different Zn concentration (12.5, 25.0, 37.5, and 50 µM) on the yield, physiological indices (net CO2 assimilation rate, transpiration, stomatal conductance, and chlorophyll fluorescence), quality, and Zn concentration of basil cultivars ‘Aroma 2’ and ‘Eleonora’ grown in a floating raft system. The ABTS, DPPH, and FRAP antioxidant activities were determined by UV-VIS spectrophotometry, the concentrations of phenolic acids by mass spectrometry using a Q Extractive Orbitrap LC-MS/MS, and tissue Zn concentration by inductively coupled plasma mass spectrometry. Although increasing the concentration of Zn in the nutrient solution significantly reduced the yield, this reduction was less evident in ‘Aroma 2’. However, regardless of cultivar, the use of the maximum dose of Zn (50 µM) increased the concentration of carotenoids, polyphenols, and antioxidant activity on average by 19.76, 14.57, and 33.72%, respectively, compared to the Control. The significant positive correlation between Zn in the nutrient solution and Zn in plant tissues underscores the suitability of basil for soilless biofortification programs.
Social responsibility and subjective well-being of volunteers for COVID-19: The mediating role of job involvement
Authors: Wu Chao , Cheng Sizhe , Zhang Yinjuan , Yan Jiaran , He Chunyan , Sa Zhen , Wu Jing , Lin Yawei , Heng Chunni , Su Xiangni , Lang Hongjuan
Published: October 2022

Aim

Our study aimed to investigate the effect of social responsibility on the subjective well-being of volunteers for COVID-19 and to examine the mediating role of job involvement in this relationship.

Background

Nowadays, more and more people join volunteer service activities. As we all know, volunteer work contributes to society without any return. Volunteers often have a strong sense of social responsibility and reap subjective well-being in their dedication. Although research shows that social responsibility will drive them to participate in volunteer work actively, it is less clear whether job involvement will impact their subjective well-being.

Methods

The data were collected in the precaution zone in Shanghai, China, from April to May 2022. A sample of 302 volunteers for COVID-19 completed the social responsibility scale, subjective well-being scale and job involvement scale in the form of an electronic questionnaire on their mobile phones. A structural equation model was adopted to verify the research hypotheses.

Results

Social responsibility was significantly and positively related to volunteers’ subjective well-being and job involvement (p < 0.05). Job involvement fully mediates the relationship between volunteers’ social responsibility and subjective well-being.

Conclusion

Social responsibility is critical to predicting volunteers’ subjective well-being. Job involvement plays an intervening mechanism in explaining how social responsibility promotes volunteers’ subjective well-being.
Quercetin Alleviates Lipopolysaccharide-Induced Cell Damage and Inflammation via Regulation of the TLR4/NF-κB Pathway in Bovine Intestinal Epithelial Cells
Authors: Gong Xiaoxiao , Huang Yinghao , Ma Qianbo , Jiang Maocheng , Zhan Kang , Zhao Guoqi
Published: October 2022

Acute diarrhoea and intestinal inflammation represent one of the most prevalent clinical disorders of milk production, resulting in enormous annual financial damage for the dairy sector. In the context of an unsatisfactory therapeutic effect of antibiotics, the natural products of plants have been the focus of research. Quercetin is an important flavonoid found in a variety of plants, including fruits and vegetables, and has strong anti-inflammatory effects, so it has received extensive attention as a potential anti-inflammatory antioxidant. However, the underlying basis of quercetin on inflammatory reactions and oxidative tension generated by lipopolysaccharide (LPS) in bovine intestinal epithelial cells (BIECs) is currently unexplained. This research aimed to determine the influence of quercetin on LPS-induced inflammatory reactions, oxidative tension, and the barrier role of BIECs. Our findings demonstrated that BIEC viability was significantly improved in LPS-treated BIEC with 80 μg/mL quercetin compared with the control group. Indicators of oxidative overload and genes involved in barrier role revealed that 80 μg/mL quercetin efficiently rescued BIECs from oxidative and barrier impairment triggered by 5 μg/mL LPS. In addition, the mRNA expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, as well as chemokines CXCL2, CXCL5, CCL5, and CXCL8, was diminished in LPS-treated BIECs with 80 μg/mL quercetin compared with LPS alone. Furthermore, the mRNA expression of toll-like receptor 4 (TLR4), CD14, myeloid differential protein-2 (MD2), and myeloid differentiation primary response protein (MyD88) genes associated with the TLR4 signal mechanism was markedly reduced by the addition of quercetin to LPS-modulated BIECs, indicating that quercetin can suppress the TLR4 signal mechanism. We performed Western blotting on the NF-κB signalling mechanism and compared it with immunofluorescence to further corroborate this conclusion. The LPS treatment enhanced the proportions of p-IκBα/GAPDH and p-p65/GAPDH. Compared with the LPS-treated group, quercetin administration decreased the proportions of p-IκBα/GAPDH and p-p65/GAPDH. In addition, immunofluorescence demonstrated that quercetin greatly reduced the LPS-induced nuclear translocation of NF-κB p65 in BIECs. The benefits of quercetin on inflammatory reactions in LPS-induced BIECs may be a result of its capacity to inhibit the TLR4-mediated NF-κB signalling mechanism. These findings suggest that quercetin can be used as an anti-inflammatory reagent to treat intestinal inflammation induced by LPS release.
What Is the Exact Contribution of PITX1 and TBX4 Genes in Clubfoot Development? An Italian Study
Authors: Bianco Anna Monica , Ragusa Giulia , Di Carlo Valentina , Faletra Flavio , Di Stazio Mariateresa , Racano Costantina , Trisolino Giovanni , Cappellani Stefania , De Pellegrin Maurizio , d’Addetta Ignazio , Carluccio Giuseppe , Monforte Sergio , Andreacchio Antonio , Dibello Daniela , d’Adamo Adamo P.
Published: October 2022

Congenital clubfoot is a common pediatric malformation that affects approximately 0.1% of all births. 80% of the cases appear isolated, while 20% can be secondary or associated with complex syndromes. To date, two genes that appear to play an important role are PTIX1 and TBX4, but their actual impact is still unclear. Our study aimed to evaluate the prevalence of pathogenic variants in PITX1 and TBX4 in Italian patients with idiopathic clubfoot. PITX1 and TBX4 genes were analyzed by sequence and SNP array in 162 patients. We detected only four nucleotide variants in TBX4, predicted to be benign or likely benign. CNV analysis did not reveal duplications or deletions involving both genes and intragenic structural variants. Our data proved that the idiopathic form of congenital clubfoot was rarely associated with mutations and CNVs on PITX1 and TBX4. Although in some patients, the disease was caused by mutations in both genes; they were responsible for only a tiny minority of cases, at least in the Italian population. It was not excluded that other genes belonging to the same TBX4-PITX1 axis were involved, even if genetic complexity at the origin of clubfoot required the involvement of other factors.
Group Differences: The Relationship between Social Media Use and Depression during the Outbreak of COVID-19 in China
Authors: Zheng Zhenhua , Liu Wanting , Yang Liu , Sun Ning , Lu Yingchen , Chen Hong
Published: October 2022

The outbreak of COVID-19 at the end of 2019 triggered more psychological problems than usual among the public. During this epidemic, the use of social media was very high, and several studies confirmed a positive correlation between social media use and people’s psychological problems. The Chinese government has subsequently implemented a series of policies concerning the social media environment to tackle this “infodemic”. After the containment of the first COVID-19 outbreak, China saw a new wave of COVID-19 cases in Shijiazhuang, Hebei Province in January 2021. How the optimized social media could have impacted public mental health remained to be revealed. Our research data come from an online survey of Chinese residents during the regional epidemic in Shijiazhuang, with a total of 904 valid samples from 18 different provinces in China. The results showed that this new round of outbreaks caused a high incidence of depression (38.9%) among the public. Compared with relatively advantaged groups, disadvantaged groups have a higher depression. Attributed to the optimization of the social media environment, the prevalence of social media use during the epidemic helped to markedly mitigate anxieties from depression. This is particularly demonstrated in vulnerable groups. We found, for the first time, a change in the relationship between social media use and resident depression, and more importantly, a stronger correlation between social media use and depression in relatively disadvantaged groups. Therefore, during the epidemic, actively optimizing the social media environment has a significant and positive effect on the mental health of residents, especially vulnerable groups.
Assessing the Landscape Ecological Risks of Land-Use Change
Authors: Gao He , Song Wei
Published: October 2022

In recent years, a changing global climate and the continuous expansion of the intensity and scope of human activities have led to regional differentiation in the surface landscape. This has caused numerous ecological risks under multiple pressure sources, gradually becoming an important factor restricting the sustainable development of economic and social health. With the continuous development of the social economy, land use and associated ecological risks will inevitably change. According to the forest transformation theory and the environmental Kuznets curve, we put forward the theoretical framework of ecological risk transformation of land-use change and took Zhangjiachuan County (China) as an example to verify it. Therefore, on the basis of Landsat satellite data, this paper used landscape structures to calculate an ecological risk index, and evaluated the ecological risk of land-use changes through pattern index analyses. The results show that, from 2000 to 2020, the ecological risk index of land-use change in Zhangjiachuan County exhibited an increasing and then decreasing trend, showing an overall “inverted U-shaped” trend of change consistent with the transformation theoretical framework of ecological risks of land use change. Secondly, in terms of patterns, the ecological risk of land-use change in Zhangjiachuan County showed a distribution feature of high in the west and low in the east. In 2000, high-risk areas were mainly concentrated in the central and northern areas, while low-risk areas were mainly concentrated in the eastern areas. From 2000 to 2015, the medium-risk areas expanded to the west and midwest, and the geographic centers of the risk areas were slightly offset. From 2015 to 2020, the overall pattern of ecological risk areas was basically the same as that of the previous stage, but the medium-risk areas were slightly reduced. In terms of quantity, from 2000 to 2015, the areas of the lowest risk level and low risk level decreased, while the areas of medium risk level, high risk level, and the highest risk level increased; from 2015 to 2020, the areas of the lowest risk level and low risk level increased, and the areas of medium risk level, high risk level, and highest risk level decreased. Lastly, the spatial aggregation of ecological risks in Zhangjiachuan County weakened slightly from 2000 to 2005, gradually increased from 2005 to 2015, and then slightly weakened from 2015 to 2020.
Molecular Dynamics Simulation of Nanoindentation of Nb-Zr Alloys with Different Zr Content
Authors: Ren Junzhao , Wu Hongyan , Wang Lu , Fan Zhehang , Qiu Yanzhao , Yu Lu , Shi Enxi
Published: October 2022

To understand the nanomechanical behaviors of the Nb-based alloys with Zr addition at room/high temperature, the molecular dynamics simulations of nanoindentation are conducted. In this work, the load-unload displacement curve, hardness, and dislocation characteristics of Nb-Zr alloys with varying Zr content ranging from 0 to 5 wt.% are studied. The simulation results are found to closely agree with the experimental one at 1 wt.%, therefore showing the reliability of the simulation. Moreover, considering distinct responses of alloys to different service temperature, the high-temperature nanoindentation are performed. The effects of Zr addition on the mechanical deformation under both temperatures are compared. The same phenomenon is found such that the optimum concentration range yielding the greatest hardness is 1–3 wt.%. The elastic modulus of NbZr alloy improves with elevated concentration at room temperature, while the hardness at higher temperature exhibits the opposite trend. This is attributed to the higher amplitude of atomic vibrations at high temperatures, which is more likely to deviate atoms from their equilibrium positions and weaken the pinning effect under external loading. Therefore, we believe that our studies on the nanomechanical mechanisms of materials at room/high temperature will provide an effective way for the alloying optimization design.
HT-29 Colon Cancer Cell Electromanipulation and Assessment Based on Their Electrical Properties
Authors: Olariu Marius Andrei , Tucureanu Catalin , Filip Tudor Alexandru , Caras Iuliana , Salageanu Aurora , Vasile Valentin , Avram Marioara , Tincu Bianca , Turcan Ina
Published: October 2022

This study proposes a feasible approach for the rapid, sensitive, and label-free identification of cancerous cells based on dielectrophoretic (DEP) manipulation and electrical characterization. In this method, the concentration of target cells at the level of customized microelectrodes via DEP is first determined, followed by an electrical impedance evaluation. The study demonstrates the capacity of the methodology to electrically differentiate HT-29 cancer cells from healthy blood cells based on their impedance spectra. Within a higher frequency domain, the electrical impedance of trapped cancer cells was significantly lower compared with the normal ones. In order to evaluate the functionality and reproducibility of the proposed method, the influence of the DEP and EIS (electrical impedance spectroscopy) operating voltages on the electrical characterization of trapped HT-29 cells was analyzed.
Correction: Solano-Aguilar et al. Fruit and Vegetable Supplemented Diet Modulates the Pig Transcriptome and Microbiome after a Two-Week Feeding Intervention. Nutrients 2021, 13, 4350
Authors: Solano-Aguilar Gloria I. , Lakshman Sukla , Shao Jonathan , Chen Celine , Beshah Ethiopia , Dawson Harry D. , Vinyard Bryan , Schroeder Steven G. , Jang Saebyeol , Molokin Aleksey , Urban Joseph F.
Published: October 2022

There was an error in the original publication [...]
Chlorogenic Acid Relieves the Lupus Erythematosus-like Skin Lesions and Arthritis in MRL/lpr Mice
Authors: Wang Ruxuan , Yang Xiaoyi , You Shen , Hao Mengyao , Li Jianguang , Chen Xiaoguang , Jin Jing
Published: October 2022

Chlorogenic acid (CGA) is a phenylpropyl substance synthesized through the shikimic acid pathway. In addition to its anti-tumor, anti-inflammatory, and antioxidant abilities, CGA also has immunomodulatory effects. The aim of the present study is to investigate the therapeutic effects of CGA on the skin damage and arthritis caused by systemic lupus erythematosus (SLE) in an MRL/lpr mouse model. In the SLE model, female MRL/lpr mice at the age of 10 weeks old were treated with CGA daily or cyclophosphamide (CTX) weekly via intraperitoneal injection for three months. After treatment, CGA can significantly alleviate the skin and mucous membrane damage caused by SLE and has a certain improvement effect on arthritis. CGA could inhibit dsDNA expression to a certain extent but has no obvious regulation on ANA concentration. The ELISA and BioMAP results indicated that CGA might play an anti-inflammatory role by down-regulating the interleukin (IL)-17 level. In conclusion, our study demonstrates that CGA can alleviate multiorgan damage in MRL/lpr mice by reducing IL-17.
Art, Heart, and Soul Music: Spiritual Values and Implications of Relational Composition within Community Music
Authors: Evison Fiona
Published: October 2022

This paper re-examines research on composers within community music who embody relational composition in which they reflect philosophical and values’ shifts, resulting in composition purposes that balance or prioritize well-being with musical products. The spiritual values that undergird the practices of certain community composers are examined through the lens of Sheldrake’s definition of spirituality as a vision for the full potential of the human spirit to live out deep and meaningful values. While not ruling out the potential for personal transcendental experience, the framework of engagement rather than escape centres a type of spirituality that is community-focused and reflects the ways in which relational composers use engagement for beneficial purposes as they seek to overcome music’s disconnections from its social contexts and extra-musical functions. This approach to composition could be viewed as a rediscovery and return to lost roles of composers in society, and it suggests that community music leaders realize the spiritual aspects of their roles in order to address healing, reconciliation, and local or global concerns and to facilitate the development of related repertoire and music-making.
What Young People Want from Clinicians: Youth-Informed Clinical Practice in Mental Health Care
Authors: Stubbing Jessica , Gibson Kerry
Published: October 2022

Evidence from around the world consistently indicates young people experience high rates of mental ill-health, but frequently have limited engagement with treatment. One powerful influence on young people’s engagement with mental health care is their relationships with treatment providers. A strong relationship with clinicians may be key to sustaining engagement, reducing dropout rates, and improving outcomes from treatment. However, research into young people’s perspectives on qualities they value in their clinicians has often been limited by traditional methodologies which explore young people’s attitudes to clinicians they have already worked with. This limits young people’s responses and, therefore, our understanding of who an effective ‘youth mental health clinician’ could be. In this study, 94 young people from New Zealand participated in innovative research workshops in which they described their ideal mental health clinician. Thematic analysis identified five themes which summarized these young peoples’ priorities for an ideal mental health clinician: Someone Like Me, Someone I Connect With, Someone Who Protects My Space, Someone Who Treats Me as an Equal, and Someone Who Works in the Right Way for Me. The presence and demonstration of these qualities may support both initial and sustained engagement with treatment, with the potential to improve outcomes for young people. Importantly, the connections between these themes highlight that young people are less likely to value ‘relatability’ as an isolated quality in their clinicians and most desire to work with clinicians who balance a warm and comfortable personal style with professional expertise and boundaries. These findings provide guidance for clinicians from a range of orientations who wish to work effectively with young people as to how they can adapt their approaches and seek feedback to improve their work with young people.
Study of the impact of storage conditions on the safety of macaroni products
Authors:   Federal State Budgetary Institution Research Institute for Problems of Storage of the Federal Reserve, Tarasova E.A. , Tarasova I.A. ,   Federal State Budgetary Institution Research Institute for Problems of Storage of the Federal Reserve, Gurieva K.B. ,   Federal State Budgetary Institution Research Institute for Problems of Storage of the Federal Reserve, Looze V.V. ,   Federal State Budgetary Institution Research Institute for Problems of Storage of the Federal Reserve
Published: October 2022

The safety of macaroni products largely depends on the storage conditions. Maintaining the optimal temperature and humidity conditions in the warehouse ensures the storage of macaroni products with the least quality changes. Based on the results of the research, scientifically substantiated parameters of temperature and relative air humidity in the warehouse, which ensure the safety of macaroni products throughout the established shelf life, are recommended.
Dryagin’s Char Salvelinus drjagini Logaschev Sobachie Lake (Putorana Plateau)
Authors:   Krasnoyarsk State Agrarian University, Russia, Krasnoyarsk, Zadelenov V.A. ,   Krasnoyarsk branch of the All-Russian Research Institute of Fisheries and Oceanography (NIIERV), Russia, Krasnoyarsk, Chetvertakova E.V. ,   Krasnoyarsk State Agrarian University, Russia, Krasnoyarsk, Alekseeva E.A. ,   Krasnoyarsk State Agrarian University, Russia, Krasnoyarsk, Timoshkina O.A. ,   Krasnoyarsk State Agrarian University, Russia, Krasnoyarsk, Logacheva O.A. ,   Krasnoyarsk State Agrarian University, Russia, Krasnoyarsk
Published: October 2022

The results of studies of some morphological, size-age and demographic characteristics of Dryagin char are presented. A distinctive feature of this char from the Boganid char common in Lake Sobachye is a wide body. Its height in mature fish reaches 27.9% of the body length. Dryagin’s char has 112–133 (121.6) perforated scales in the lateral line, 21–29 (26.11) rakers on the first gill arch. The Dryagin char differs from the Boganid char in the color of immature and adult fish. In the control catches, fish aged from 3 to 14 years were noted, fish aged 8–10 years dominated. The length of Dryagin’s char (SL) ranged from 318 to 810 mm, weight — 472–10 700 g. The sex ratio was approximately 60:40 in favor of males. At the age of 6 years, the fish reaches sexual maturity, the maturation period is extended to 8–9 years. The minimum values of individual absolute fecundity in char were noted at the age of 6 years — 3833, the maximum — 18 270, the average value of the trait — 8140 eggs. The value of fecundity functionally depends on the mass of the fish (correlation coefficient 0.83) and its size (correlation coefficient 0.77). It is concluded that the large size, with almost the same maturation time of Dryagin char and Boganid char, makes the former a more preferable object for introducing native species into aquaculture for the Krasnoyarsk Territory.
The Caspian Scientific Research Institute of Fisheries (CaspNIRKH) is 125 years old!
Authors:   Department of biology, bioresources and aquaculture, Novosibirsk state agrarian University, Novosibirsk, Russia, Pishchenko E. V.
Published: October 2022

ANNIVERSARY DATE. The Caspian Scientific Research Institute of Fisheries (CaspNIRKH) is 125 years old.
Apontamentos sobre a educação quilombola no Quilombo São José da Serra em Valença – RJ
Authors:   , Oliveira Eunice Aparecida Sampaio de
Published: October 2022

A presente pesquisa de mestrado busca compreender o processo educacional dentro da comunidade quilombola de São José da Serra, localizada no Município de Valença, região Sul Fluminense do Estado do Rio de Janeiro. O objetivo primordial é realizar um apontamento sobre a Educação Quilombola na referida comunidade, buscando analisar a dinâmica da relação da educação quilombola com a educação escolar quilombola. Para tanto, adota-se como objetivo específico compreender se existe uma pedagogia própria na instituição escolar que garanta o respeito as especificidades da comunidade quilombola São José da Serra e, valorize os saberes dos quilombolas, dialogando juntamente com os saberes escolares. O caminho percorrido para esses fins iniciou-se com uma revisão de literatura, que foi a base para estruturar as categorias propostas: quilombo, educação quilombola e educação escolar quilombola. Posteriormente, foi realizado entrevista virtual com os membros da comunidade quilombola: duas professoras da comunidade escolar e duas pessoas da comunidade, sendo esses, o líder e uma ativista. O instrumento para coleta de dados foram 12 questões norteadoras da entrevista virtual, que foi realizada de modo individual e mediada através dos Softwares Google Meet e Zoom. Os dados oriundos dos resultados foram correlacionados com base tanto na comparação e associação dos discursos dos envolvidos, quanto utilizando-se as categorias levantadas para subsidiar a interpretação. A discussão foi estabelecida à luz do respaldo da legislação atual e da revisão de literatura efetuada. A pesquisa tem o perfil de um estudo de caso fundamentado previamente por uma revisão de literatura, com abordagem qualitativa, natureza aplicada, e o objetivo de cunho exploratório. Os resultados apontam que há alguns pontos convergentes nas entrevistas, todavia, a maioria das respostas não se relacionam, sugerindo uma desarmonia entre a atuação docente com os propósitos da educação escolar quilombola. Conclui-se que, na comunidade de São José da Serra, a educação quilombola e a educação escolar quilombola coexistem de modo longínquo, não estabelecendo dinâmica entre si. Enfatiza-se, neste aspecto, que a escola não deveria estar a parte da comunidade, mas sim dentro da comunidade, abrangendo as particularidades de toda cultura quilombola. É evidente a ausência de políticas públicas mais efetivas que promovam qualificação profissional e, realize inspeções institucionais nas comunidades escolares quilombolas para supervisionar se a prática da educação escolar quilombola está assegurando o respeito pela cultura e inclusão de saberes próprios da comunidade.
Potencial citogenotóxico de nanotubos de carbono em Lactuca sativa L. (Asteraceae)
Authors:   , Siqueira Juliana Tatiara da Costa
Published: October 2022

-
O treinamento de voleibol das categorias sub-15 a sub-19 no naipe masculino: uma proposta de organização metodológica.
Authors:   , Nascimento Marcos Henrique do
Published: October 2022

Em função da carência de estudos que abordem a organização metodológica dos treinamentos de voleibol nas categorias de 15 a 19 anos, observou-se uma necessidade de se construir uma proposta de treinamento global para jovens atletas de voleibol, tendo como referência modelos desenvolvidos em outras realidades, respeitando o princípio da individualidade da preparação (biológica) e baseando todo o trabalho na perspectiva da preparação a longo prazo. Em nossa proposta metodológica apresentaremos currículos de desenvolvimento específico para cada fundamento técnico (saque, manchete, recepção, levantamento, cortada, bloqueio e defesa) e suas interações no contexto tático. Trata-se de um procedimento de estruturação dos conteúdos estudados, avaliando sua importância para cada faixa etária (BOJIKIAN,2013). Para isso, buscamos na revisão de literatura aspectos importantes como (Crescimento e desenvolvimento, Treinamento a longo prazo, Treinamento com os jovens, A permanência e o abandono da prática esportiva, Caracterização do voleibol e o Talento esportivo no voleibol), além da construção de uma base de informações sobre os componentes técnicos e táticos de cada fundamento, auxiliando na formação dos currículos de desenvolvimento dos fundamentos. Esses currículos que acreditamos ser o diferencial do trabalho dentro da proposta de modelo de formação apresentada. Nossa proposta tem como finalidade ajudar sendo uma base para a estruturação de novos planejamentos sistematizados e adaptações a outras realidades. Para isso acreditamos que seja de extrema importância toda a união desses conhecimentos, aplicados na prática, auxiliando no melhor desenvolvimento de jovens atletas e da evolução dos programas de treinamentos.