bluuebunny/crossref_metadata_2025 huggingface dataset:
PENILAIAN RISIKO LINGKUNGAN TERHADAP PENGARUH DARI PENGOLAHAN PUPUK ORGANIK DI RUMAH SAMPAH LAKESSI BERSAHAJA DI KELURAHAN LAKESSI KABUPATEN SIDENRENG RAPPANG
Authors: Asny Septiani  , Rahmi Amir  , Nur Haeda
Published: January 2020

Pengolahan pupuk organik yang berasal dari sampah organik ditemukan bahaya yang terkandung di dalamnya sehingga dapat menyebabkan keterpaparan pada pekerja dalam melakukan pengolahan  pupuk organik yang berpotensi berbahaya, kita ketahui bahwa pupuk organik baik untuk tanaman tapi tidak diketahui dampak dari pengolahan pupuk organik.Tujuan penelitian ini untuk mengetahui risiko lingkungan terhadap pengaruh dari pengolahan pupuk organik baik dari segi efek secara langsung maupun dari segi efek secara tidak langsung di Rumah Sampah Lakessi Bersahaja Kelurahan Lakessi Kabupaten sidenreng Rappang.Metode yang digunakan dalam penelitian ini adalah metode deskriptif Peneliti mengidentifikasi melalui observasional dengan menggunakan kuesioner pada sampel, dimana sampel dalam penelitian ini pekerja yang melakukan pengolahan pupuk organik sebanyak 8 orang. Data dianalisis secara univariat dan bivariat  menggunakan uji statistik Chi Square dan Fisher’s Exact Test. Hasil penelitian menunjukkan bahwa ada pengaruh risiko kesehatan (0,036 < 0,05), dan ada estimasi secara langsung (0,036 < 0,05) dari penilaian risiko lingkungan terhadap pengaruh dari pengolahan pupuk organik di Rumah sampah Lakessi Bersahaja Kelurahan Lakessi Kabupaten Sidenreng Rappang. Hendaknya pemerintah pusat memperhatikan lokasi sebelum membangun suatu tempat pengolahan sampah karena lokasi tersebut dekat dengan sarana pendidikan, dan bagi pengelolah ruimah sampah Lakessi Bersahaja Kelurahan Lakessi Kabupaten Sidenreng Rappang, Untuk menyiapkan  APD bagi para pekerja
FAKTOR-FAKTOR YANG MEMPENGARUHI KEMAMPUAN PENYULUH KESEHATAN MASYARAKAT TERHADAP PELAKSANAAN CAKUPAN PROGRAM PROMOSI KESEHATAN DI KOTA PAREPARE
Authors: Armiati  , Usman  , Abidin
Published: January 2020

Promosi kesehatan merupakan upaya yang bersifat promotif (peningkatan) sebagai perpaduan dari upaya preventif (pencegahan), kuratif (pengobatan), dan rehabilitatif (pemulihan) dalam rangkaian upaya kesehatan yang komprehensif. Untuk melaksanakan upaya kesehatan wajib tersebut di puskesmas diperlukan tenaga fungsional penyuluh kesehatan masyarakat untuk mengelola promosi kesehatan di puskesmas secara profesional dan mampu untuk mengelola serta menyelenggarakan pelayanan yang bersifat promotif dan preventif. penelitian ini bertujuan untuk menunujukkan apakah tingkat pengetahuan dan keterampilan penyuluh kesehatan masyarakat berpengaruh terhadap pelaksanaan cakupan program promosi kesehatan di Kota Parepare. Penelitian menggunakan survei analitik dengan pendekatan cross sectional study. Waktu penelitian pada bulan Mei-Juli 2018 dengan jumlah sampel 31 petugas yang terdiri dari Dinas kesehatan dan Puskesmas se Kota Parepare. Data di analisis secara univariat dan bivariat dengan menggunakan uji ststistik uji Chi-Square. Hasil penelitian  menunjukkan bahwa ada pengaruh tingkat pengetahuan  (p = 0,053), keterampilan ( p = 0,000) terhadap pelaksanaan cakupan program promosi kesehatan di Kota Parepare. Berdasarkan hasil tersebut, disarankan Perlunya disiplin ilmu terutama pada bidang promosi kesehatan agar  lebih memudahkan petugas mengelolah program promosi kesehatan yang ada di Dinas Kesehatan ataupun puskesmas di Kota Parepare
PENGARUH PENGGUNAAN PEMBALUT SAAT MENSTRUASI TERHADAP RISIKO KANKER SERVIKS PADA SISWI SMA NEGERI 2 PANGKAJENE SIDENRENG RAPPANG
Authors: Annisa Baharuddin  , Henni Kumaladewi Hengky  , Ayu Dwi Putri Rusman
Published: January 2020

Perilaku kurang baik dalam pemilihan pembalut yang biasa dibeli dan dipakai oleh remaja putri selama ini, hanya memikirkan harga murah dan cukup enak dipakai, tanpa mengetahui risiko kesehatan dari pemakaian pembalut. Kondisi inilah yang membuat pembalut menjadi sumber sarang pertumbuhan bakteri merugikan yang berisiko terhadap masalah kesehatan reproduksi hingga risiko kanker serviks. Penelitian ini bertujuan untuk menjelaskan pengaruh penggunaan pembalut saat menstruasi terhadap risiko kanker serviks pada siswi SMA Negeri 2 Pangkajene Sidrap. Penelitian ini menggunakan cross sectional study. Lokasi penelitian di SMA Negeri 2 Pangkajene Sidrap. Waktu penelitian pada bulan Mei-Juni 2018. Populasinya yaitu Siswi kelas X dan IX yang telah mengalami menstruasi dengan metode pengambilan sampel yaitu porposive sampling dengan jumlah 100 sampel.Hasil penelitian menunjukkan bahwa ada pengaruh perilaku hygiene (0,021), tingkat pengetahuan (0,013), dan kualitas pembalut (0,001), sedangkan tidak ada pengaruh keterpaparan terhadap informasi kesehatan (0,821), terhadap risiko kanker serviks pada siswi SMA Negeri 2 Pangkajene Sidrap. Berdasaran hasil tersebut, disarankan kepada peneliti selanjutnya untuk meneliti tentang kandungan dalam pembalut sehingga terhindar dari risiko kesehatan reproduksi dan untuk pemerintah agar melaksanakan kegiatan sosialisasi KIE disertai dengan pemberian poster atau leaflet terkait kesehatan reproduksi pada remaja putri terutama personal hygiene saat menstruasi
EFEKTIVITAS ARANG SEKAM PADI DALAM MENURUNKAN KADAR BESI (Fe) PADA AIR SUMUR BOR DI DESA PADANGLOANG KABUPATEN PINRANG
Authors: Riskawati  , Rahmi Amir  , Herlina Miun
Published: January 2020

Kadar besi (Fe) yang melebihi ambang batas dapat menimbulkan dampak negatif terhadap air antara lain kondisi air berwarna kuning, berasa dan bau besi atau karat. Sedangkan efek negatif pada kesehatan manusia adalah dapat menggangu sistem reproduksi dan berpotensi sebagai pemicu kanker apabila dikomsumsi dalam kurun waktu lama. Tujuan penelitian ini adalah untuk mengetahui efektifitas arang sekam padi dalam menurunkan kadar besi (Fe) pada Sumur Bor di Dusun Banga Desa Padangloang Kabupaten Pinrang, Jenis penelitian ini adalah quasy eksperimen dimana setiap perlakuan dilakukan pengulangan sebanyak 3 kali. Hasil pada penelitian ini yaitu  kadar besi (Fe) sebelum perlakuan sebanyak 1,81 mg/l dan setelah perlakuan penambahan arang sekam padi dengan konsentrasi yang berbeda terjadi penurunan kadar besi (Fe) pada Sumur Bor di Dusun Banga Desa Padangloang Kabupaten Pinrang. Dari  konsentrasi 5 gram, 10 gram, dan 15 gram yang paling efektif untuk menurunkan kadar besi (Fe) adalah 15 gram dengan 100 ml air, hasil yang didapatkan 0,30 mg/l. Semakin banyak jumlah konsentrasi arang sekam padi maka semakin tinggi tingkat penurunan kadar besi (Fe). Arang sekam padi dapat dikatakan efektif dalam menurunkan kadar besi (Fe) pada air sumur bor di Dusun Banga Desa Padangloang Kabupaten Pinrang sesuai dengan peraturan yang telah ditetapkan oleh Peraturan Menteri Kesehatan RI Nomor 492/Menkes/Per/IV/2010 tentang persyaratan kualitas air bersih
FAKTOR-FAKTOR YANG MEMPENGARUHI PENDERITA HIPERTENSIDALAM MENGGUNAKAN OBAT NONFARMAKOLOGI DI WILAYAH KERJA PUSKESMAS CEMPAE KOTA PAREPARE
Authors: Nursyafitri  , Abidin  , Amir Patintingan
Published: January 2020

Obat Nonfarmakologi adalah obat tradisional yang menggunakan bahan-bahan alami yang mudah didapat karena bisa ditemukan disekitar lingkungan, dimana pengobatan nonfarmakologi memiliki kelebihan dalam banyak hal, serta tidak memiliki efek samping bagi tubuh.Beberapa faktor-faktor yang mempengaruhi penderita hipertensi dalam menggunakan obat nonfarmakologi adalah tingkat pengetahuan, perilaku, kepercayaan.Penelitian ini bertujuan untuk menjelaskan Faktor-Faktor yang Mempengaruhi Penderita Hipertensi dalam Menggunakan Obat NonFarmakologi di Wilayah Kerja Puskesmas Cempae Kota Parepare, serta memberikan informasi yang selama ini mereka belum pahami secara jelas. Penelitian ini menggunakan cross sectional. Lokasi penelitian dilakukan di Wilayah Kerja Pusekesmas Cempae Kota Parepare.Adapun waktu penelitian dilakukan pada bulan Juni-Juli 2018.Populasinya adalah penderita hipertensi dengan pengambilan sampel yaitu accidental sampling dengan jumlah 100 sampel.Hasil penelitian menunjukkan bahwa ada pengaruh tingkat pengetahuan (0,035 < 0,05), perilaku (0,004 < 0,05), dan kepercayaan (0,023 < 0,05), penderita hipertensi dalam menggunakan obat nonfarmakologi di Wilayah Kerja Puskesmas Cempae Kota Parepare.
PERANAN POSYANDU DALAM MENINGKATKAN STATUS GIZI BALITA DI WILAYAH KERJA PUSKESMAS MADISING NA MARIO KOTA PAREPARE
Authors: Aldita Angeraini  , Muhammad Siri dangnga  , Erna Magga
Published: January 2020

Balita adalah individu atau sekelompok individu dari suatu penduduk yang berada di dalam rentang usia tertentu, pada masa balita perkembangan kemampuan berbahasa, kreativitas, kesadaran sosial, dan inteligensia berjalan sangat cepat. Faktor gizi sangat berperan sekali dalam pertumbuhan dan perkembangan anak selanjutnya. Tujuan penelitian ini untuk mengetahui kegiatan pemberian imunisasi, pemberian makanan tambahan, penimbangan berat badan dan penyuluhan dalam meningkatkan status gizi balita di wilayah kerja Puskesmas Madising Na Mario Kota Parepare, pada bulan Mei-Juni 2018. Populasi penelitian ini adalah seluruh ibu yang memiliki balita di Puskesmas Madising Na Mario Kota Parepare dengan metode pengambilan sampel yaitu Simple Random Sampling dengan jumlah 87 sampel. Metode yang digunakan dalam penelitian ini adalah metode deskriptif yang bertujuan untuk mengetahui suatu gambaran terhadap posyandu dalam meningkatkan status gizi balita. Hasil penelitian menunjukkan bahwa pemberian imunisasi lengkap sebanyak 87 responden (100%), pemberian makanan tambahan baik sebanyak 85 responden (97,7%), penimbangan berat badan akurat sebanyak 80 responden (92%), dan penyuluhan baik sebanyak 82 responden (94,3%).Diharapakan ibu balita meningkatkan kelengkapan imunisasi, pemberian makanan tambahan, penimbangan berat badan, penyuluhan guna meningkatkan status gizi balita.
HUBUNGAN PENYAKIT KECACINGAN DENGAN STATUS GIZI ANAK PADA SEKOLAH DASAR MUHAMMADIYAH JAMPU KECAMATAN LANRISANG KABUPATEN PINRANG
Authors: Devi Astuti  , Erna Magga  , Makhrajani Majid  , Abidin Djalla
Published: January 2020

Pada tahun 2017 jumlah kasus penderita cacingan di Kabupaten Pinrang sebanyak 366 kasus. Kecamatan Lanrisang merupakan kecamatan dengan jumlah penderita cacingan tertinggi selama tahun 2017 dengan 125 kasus. Usia yang masih rentan untuk terinfeksi cacingan terdapat pada kelompok usia sekolah yaitu 6-12 tahun, oleh karena itu penelitian ini akan fokus pada kelompok usia Sekolah Dasar. Tujuan penelitian ini untuk menjelaskan hubungan antara status gizi dengan penyakit kecacingan pada siswa SD Muhammadiyah Jampu Kecamatan Lanrisang Kabupaten Pinrang. Jenis penelitian ini adalah survei analitik dengan pendekatan study, instrument penelitian yang digunakan adalah uji lab dan kuesioner. Populasi dalam penelitian ini adalah seluruh siswa kelas 1, 2 dan 3 di Sekolah Dasar Muhammadiyah Jampu Kecamatan Lanrisang Kabupaten Pinrang yang berjumlah 26 siswa. Teknik pengambilan sampel dilakukan dengan total sampling. Analisis data dilakukan dengan analisis univariat dan bivariat. Hasil penelitian menunjukkan bahwa terdapat 19 siswa (73,3%) dengan status gizi normal dan 7 siswa (26,3%) dengan status gizi kurus. Jumlah siswa yang positif cacingan sebanyak 6 siswa (23,7) dan yang negatif sebanyak 20 siswa 76,3%). Dari uji chi-square yang dilakukan menunjukkan bahwa terdapat hubungan antara status gizi dengan penyakit kecacingan siswa pada SD Muhammadiyah Jampu Kecamatan Lanrisang Kabupaten Pinrang.
HUBUNGAN KEBIASAAN KONSUMSI MAKANAN CEPAT SAJI DAN ASUPAN ENERGI DENGAN KEJADIAN OBESITAS PADA MAHASISWA YANG TINGGAL DI SEKITAR UNIVERSITAS MUHAMMADIYAH PAREPARE
Authors: Nur Annisa Resky  , Haniarti  , Usman
Published: January 2020

Obesitas merupakan akumulasi lemak abnormal atau berlebihan yang dapat mengganggu kesehatan yang disebabkan oleh asupan energi yang berlebih seperti karbohidrat, lemak dan protein. Mahasiswa cenderung mengkonsumsi makanan yang tinggi lemak seperti makanan cepat saji. Penelitian ini bertujuan untuk menjelaskan tentang hubungan kebiasaan konsumsi makanan cepat saji dan asupan energi dengan kejadian obesitas pada mahasiswa yang tinggal di sekitar Universitas Muhammadiyah Parepare. Metode penelitian yang digunakan adalah penelitian analitik dengan desain cross sectional. Data diperoleh dengan membagikan kuesioner kepada 99 mahasiswa yang di jadikan sampel mulai bulan Juli sampai Agustus 2018. Analisis penelitian yang digunakan adalah uji chi-square. Hasil penelitian menunjukkan bahwa ada hubungan yang signifikan antara kebiasaan konsumsi makanan cepat saji dan asupan energi dengan kejadian obesitas pada mahasiswa yang tinggal di sekitar Universitas Muhammadiyah Parepare. Bagi mahasiswa sebaiknya mengkonsumsi makanan yang bergizi dan beragam agar memiliki tubuh yang sehat, sehingga dapat mengikuti perkuliahan dengan baik.
ANALISIS FAKTOR RISIKO KEKURANGAN ENERGI KRONIS IBU HAMIL DI KOTA PAREPARE
Authors: Nurkhaira Mazita J  , Nuddin Andi , Henni Kumaladewi Hengky
Published: January 2020

Kekurangan Energi Kronis (KEK) adalah salah satu keadaan malnutrisi pada ibu hamil, yang dapat di ukur melalui pengukuran Lingkar Lengan Atas (LILA) menggunakan pita LILA). Secara umum Pravalensi KEK di Sulawesi Selatan hanya 12,5% termasuk Kota Parepare yang pravelansinya (9,75%). Tujuan Penelitian ini untuk menunjukkan apakah faktor usia ibu, jarak kehamilan, asupan zat gizi dan pantang makan mempengaruhi Risiko KEK ibu hamil di Kota Parepare.Metode yang digunakan dalam penelitian ini adalah metode analitik dengan pendekatan Cross Sectional Study. Peneliti mengidentifikasi melalui observasional dengan menggunakan kuesioner pada sampel, dimana sampel dalam penelitian ini sebanyak 63 orang ibu hamil di Kota Parepare. Data dianalisis secara univariat dan bivariat  menggunakan uji statistik Chi Square melalui SPSS Versi 24 Hasil penelitian menunjukkan bahwa ada pengaruh Usia Ibu 0,030, ada pengaruh Jarak Kehamilan 0,488, tidak ada pengaruh Asupan Zat Gizi 0,341 dan ada pengaruh Pantang Makan 0,000 terhadap Risiko KEK ibu hamil di Kota Parepare. Disarankan sebaiknya pada wanita yang ingin menikah merencanakan terlebih dahulu jika ingin menikah muda dikarenakan umur yang baik untuk menikah ialah 20-35 tahun dikarenakan pada usia itu kondisi yang baik dalam kehamilan, sebaiknya ibu hamil lebih banyak mengkonsumsi makanan yang sangat diperlukan oleh janin dan lebih banyak memperluas pengetahuan tentang kehamilan dan makanan yang dikonsumsinya dan bagi pasangan usia subur (PUS) yang menginginkan kehamilan sebaiknya dipersiapkan secara menyeluruh terutama kebutuhan akan makanan yang dibutuhkan ibu sebelum dan selama hamil sehingga tidak terjadi defisiensi Gizi terutama kebutuhan akan Energi.
PENGARUH UAP ROKOK ELEKTRIK TERHADAP KUALITAS UDARA AMBIEN PADA LINGKUNGAN PENGGUNA ROKOK ELEKTRIK DI KOTA PAREPARE
Authors: Ardiyan Sabir  , Muhammad Asikin  , Ilham Willem
Published: January 2020

Sumber pencemaran udara adalah hadirnya kontaminan di ruang terbuka dengan konsentrasi dan durasi yang sedemikian rupa, sehingga mengakibatkan gangguan, merugikan makhluk hidup dan menyebabkan kualitas udara tidak sesuai dengan peruntukannya. Kualitas udara terbagi menjadi dua, yaitu kualitas udara emisi dan kualitas udara ambien. Rokok elektrik  adalah suatu perangkat dengan tenaga baterai yang menyediakan dosis nikotin hirup memberikan efek sama seperti merokok konvensional. Uap rokok elektrik yang keluar, tetap saja masuk ke dalam polusi udara. Walaupun tidak sebanyak asap yang keluar dari rokok tembakau konvensional biasa, namun uap yang dihasilkan oleh rokok elektrik juga bisa dikategorikan sebagai polusi udara. Tujuan penelitian ini untuk mengetahui pengaruh uap rokok elektrik terhadap kualitas udara ambien pada ruangan terbuka dan pada ruangan tertutup di lingkungan pengguna rokok elektrik Kota Parepare. Metode yang digunakan dalam penelitian ini adalah metode Quasy Eksperiment dengan desain penelitian one group pretest – post test. Peneliti mengidentifikasi melalui pengujian dengan menggunakan alat Yes Air kemudian dilakukan pencatatan ke dalam lembar observasi, dimana sampel dalam penelitian ini sebanyak 2 ruangan yaitu ruangan terbuka dan ruangan tertutup. Hasil penelitian menunjukkan bahwa ada pengaruh uap rokok elektrik terhadap kualitas udara ambien pada ruangan terbuka dan pada ruangan tertutup di lingkungan pengguna rokok elektrik Kota Parepare. Penelitian ini menyarankan kepada pengelola cafe hendaknya memasangan exhaust fan agar parameter pencemar udara tidak mengendap di dalam ruangan.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KUNJUNGAN BALITA KE POSYANDU DI WILAYAH KERJA PUSKESMAS MANGKOSO KABUPATEN BARRU
Authors: Satriani  , Syarifuddin Yusuf  , Ayu Dwi Putri Rusman
Published: January 2020

Posyandu merupakan wadah untuk mendapatkan pelayanan dasarterutama dilaksanakan oleh kader yang telah dilatih dibidang kesehatan dan KB, dimana anggotanya berasal dari PKK, tokoh masyarakat dan pemudi. Kader kesehatan merupakan perwujudan peran serta aktif masyarakat dalam pelayanan terpadu, dengan adanya kader yang dipilih oleh masyarakat, kegiatan diprioritaskan pada lima program dan mendapat bantuan dari petugas kesehatan terutama pada kegiatan yang mereka tidak kompeten memberikannya. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan kunjungan balita ke posyandu di wilayah kerja Puskesmas Mangkoso Kabupaten Barru. Penelitian ini bersifat analitik dengan pendekatan cross sectional, populasi sebanyak 1.112 balita, sampel penelitian 100 balita. Teknik pengambilan sampel Accidental sampling.Pengumpulan data melalui kuesioner.Penelitian di lakukan di posyandu wilayah kerja Puskesmas Mangkoso pada bulan Juni sampai Juli 2017. Hasil ujichi squaremenunjukkan bahwa yang mempengaruhikunjungan ke posyandu adalah pengetahuan orang tua (0,000), paritas (0,020), status pekerjaan (0,000) dan jarak tempat tinggal (0,004). Disarankan sebagai kesehatan masyarakat masukan tentang  kunjungan posyandu balita,  partisipasi masyarakat terhadap kunjungan ke posyandu dan sebagai bahan masukkan bagi petugas kesehatan di Puskesmas Mangkoso
The Strassen invariance principle for certain non-stationary Markov–Feller chains
Authors: Czapla Dawid , Horbacz Katarzyna , Wojewódka-Ściążko Hanna
Published: January 2020

We propose certain conditions implying the functional law of the iterated logarithm (the Strassen invariance principle) for some general class of non-stationary Markov–Feller chains. This class may be briefly specified by the following two properties: firstly, the transition operator of the chain under consideration enjoys a non-linear Lyapunov-type condition, and secondly, there exists an appropriate Markovian coupling whose transition probability function can be decomposed into two parts, one of which is contractive and dominant in some sense. Our criterion may serve as a useful tool in verifying the functional law of the iterated logarithm for certain random dynamical systems, developed e.g. in biology and population dynamics. In the final part of the paper we present an example application of our main theorem to a mathematical model describing stochastic dynamics of gene expression.
Global Postural Re-education in non-specific neck and low back pain treatment: A pilot study
Authors: Cavalcanti Isabela Franco , Antonino Gabriel Barreto , Monte-Silva Katia Karina do , Guerino Marcelo Renato , Ferreira Ana Paula de Lima , das Graças Rodrigues de Araújo Maria
Published: January 2020

BACKGROUND: Spinal pain is an important public health issue that brings biopsychosocial problems. Global Postural Re-education (GPR) is one of its treatments. OBJECTIVE: Evaluate the effects of GPR on pain, flexibility, and posture of individuals with non-specific low back pain and/or neck pain for more than six weeks. METHODS: The study enrolled 18 individuals, which were randomized into two groups: GPR group (GPRG; n= 09), submitted to 10 sessions of GPR and control group (CG; n= 09), not submitted to any technique. The evaluations were done before and after the GPRG sessions, for pain perception (Visual Analogue Scale – VAS), flexibility (finger-floor test) and posture (SAPO). The re-evaluation was done in the GPRG after the end of 10 treatment sessions and, in the GC, after the time equivalent to 10 sessions. The level of significance was set at p< 0.05. RESULTS: This pilot study has no homogeneity between groups. GPRG presented improvement in pain and flexibility, but showed no changes in posture. In the CG, there was no difference in the variables evaluated in this study. CONCLUSION: GPR had positive effects on pain and flexibility, but did not present a significant effect on posture.
Genetic susceptibility of CYP1A1 gene and risk of pesticide exposure in prostate cancer
Authors: Abhishek Amar , Ansari Nasreen Ghaji , Singh Vishwajeet , Sinha Rahul Janak , Mishra Prabhakar , Mishra Abhishek
Published: January 2020

BACKGROUND: The etiology of prostate cancer (PCa) is multi-factorial including environmental and genetic factors. Present study evaluates the association between level of pesticides, stress level and CYP1A1 gene polymorphism with PCa patients. METHODS: A case control study was conducted with 102 PCa patients and age match symptomatic (n= 107) and asymptomatic benign prostatic hyperplasia (BPH, n= 70) patients. Pesticide level was characterized by Gas Chromatography. The oxidative stress and scavenging mechanisms were determined by biochemical method. Two polymorphisms of CYP1A1 gene, rs4646903 and rs1048943, were analyzed by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism and allele specific PCR method. RESULTS: Higher level of pesticide namely beta-hexachlorocyclohexane (β-HCH), Malathion, Chlorpyrifos and Fenvalerate were found in PCa group (all p value: < 0.05). Kruskal Wallis H test depicted that level of β-HCH and Malathion significantly correlated with higher grade of PCa (all p< 0.05). The PCa Patients with simultaneously low antioxidant activity and high stress level tended to suffer worst clinical outcomes. Dominant model of rs4646903 and rs1048943 suggested that substitution is associated with a higher risk of PCa (OR: 2.2, CI: 1.6–3.8, p: 0.009 and OR: 1.95, CI: 1.1–3.4, p: 0.026; respectively) and this risk was also influenced by smoking and pesticide exposure. CONCLUSION: Environmental and genetic factors are reported to raise risk; person with high level of these pesticides especially in high risk genotype might be more susceptible to PCa.
The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in mice
Authors: Grambow Eberhard , Klee Gina , Klar Ernst , Vollmar Brigitte
Published: January 2020

INTRODUCTION: Neointima formation is closely linked to vascular stenosis and occurs after endothelial damage. Hydrogen sulfide is an endogenous pleiotropic mediator with numerous positive effects on the cardio vascular system. OBJECTIVE: This study evaluates the effect of the slow releasing hydrogen sulfide donor GYY4137 (GYY) on neointimal formation in vivo. METHODS: The effect of GYY on neointimal formation in the carotid artery was studied in the FeCl3 injury model in GYY- or vehicle-treated mice. The carotid arteries were studied at days 7 and 21 after treatment by means of histology and immunohistochemistry for proliferating cell nuclear antigen (PCNA) and alpha smooth muscle actin (α-SMA). RESULTS: GYY treatment significantly reduced the maximal diameter and the area of the newly formed neointima on both days 7 and 21 when compared to vehicle treatment. GYY additionally reduced the number of PCNA- and α-SMA-positive cells within the neointima on day 21 after FeCl3 injury of the carotid artery. CONCLUSIONS: Summarizing, single treatment with the slow releasing hydrogen sulfide donor GYY reduced the extent of the newly formed neointima by affecting the cellular proliferation at the site of vascular injury.
Characteristics of the productive-economic indicators of cows of Yaroslavl breed of different genotypes
Authors: Kosyachenko N. , Abramova Marina , Lapina M.
Published: January 2020

Abstract. Aim. The study of the influence of crossbriding on the growth and development of heifers and subsequent productive and reproductive qualities of cows on the first lactation. Methods. Using statistical methods, correlation analysis and ANOVA for evaluated genetic indicators of economic-valuable traits of dairy cattle. In particular was studied live weight of heifers from birth to 18 months, first insemination age and first fecundation age, live weight at fecundation, frequency of insemination, first calving age, days open, live weight at first lactation, milk yield for 305 days (kg), fat (%, kg) and protein (%, kg) in milk. Results. Relationship between productive indicators and the genotype of the animal is established. When assessing the strength of the influence of the factor «blood on the Holstein breed» it was found that the greatest impact can be traced at the age of 6 and 18 months, and is respectively 12.7 % and 17.1 %.The reproductive qualities of the first-calf cows decreased with the increase percent of blood in the Holstein breed. Evaluation of the impact of crossbreeding on milk production at first lactation has revealed significant strong influence on milk yield for 305 days of first lactation, and related signs the amount of milk fat and protein. According to qualitative indicators, the low influence of the Holstein blood fraction was found, while to a greater extent on the fat content than on the protein content in milk. Evaluation of phenotypic and genotypic correlations of milk yield and quality components of milk revealed average negative phenotypic and low negative genotypic correlation in all groups. The exception was in heifers of Yaroslavl breed with percent of Holstein blood less than 50 %, in which the relationship of yield x protein was positive. The relationship between milk yield and fat and protein content in milk has the opposite moderate character and strength. Practical significance. Studies was established that breeding of animals of Holstein and Yaroslavl breeds in one herd allows to receive an optimum ratio of milk production with optimal percentage fat and protein. For this herd among animals of the improved genotypes of the Yaroslavl breed, the use of genotypes with a percent of blood in the Holstein breed from 75.1 % to 87.6 % is optimal, which should be taken into account when selecting bulls to the breeding program.
Surface Charge Mapping on Virions and Virus-Like Particles of Helical Plant Viruses
Authors: Arkhipenko M. V. , Nikitin N. A. , Baranov O. A. , Evtushenko E. A. , Atabekov J. G. , Karpova O. V.
Published: January 2020

Currently, the assembly of helical plant viruses is poorly understood. The viral assembly and infection may be affected by the charge distribution on the virion surface. However, only the total virion charge (isoelectric point) has been determined for most plant viruses. Here, we report on the first application of positively charged magnetic nanoparticles for mapping the surface charge distribution of helical plant viruses. The charge was demonstrated to be unevenly distributed on the surface of viruses belonging to different taxonomic groups, with the negative charge being predominantly located at one end of the virions. This charge distribution is mainly controlled by viral RNA.
“Shielding” of Cytokine Induction by the Periodontal Microbiome in Patients with Periodontitis Associated with Type 2 Diabetes Mellitus
Authors: Balmasova I. P. , Lomakin Y. A. , Babaev E. A. , Tsarev V. N. , Gabibov A. G. , Smirnov I. V. , Knorre V. D. , Ovchinnikova L. A. , Gnuchev N. V. , Khurs E. N. , Deev M. S. , Kostin N. N. , Arutyunov S. D.
Published: January 2020

Periodontal diseases, especially those with polymicrobial etiology, are often associated with type 2 diabetes mellitus, proceeding more severely and affecting the course of diabetes mellitus. Recently, this feature has been associated with the ability of periodontopathogen microflora to cause not only a local infectious process in the oral cavity, but also to interact with the human immune system and induce various systemic effects. We investigated changes in the salivary cytokine profile of patients with chronic periodontitis, associated and not associated with type 2 diabetes mellitus. We observed a statistically significant decrease of MCP-1/CCL2, GM-CSF, IL-5, IL-6, and IFN- in the saliva of patients with chronic periodontitis associated with type 2 diabetes mellitus in comparison with patients with chronic periodontitis only. All of these cytokines are associated with macrophage activation. These data are an important contribution to the elucidation of the mechanism of periodontopathogens involvement in the manifestation of the systemic effects of type 2 diabetes.
新课改要求下高中体育课堂教学模式探讨
Authors: 马 瑞玲
Published: January 2020

新课改的背景下,广大教育工作者纷纷紧随时代发展步伐对教育教学进行改革与创新。当前传统的高中体育教学模式存在诸多弊端与问题,难以有效培养学生的综合素养。因此,结合笔者教学经验,对高中体育课堂教学模式的改进与创新进行探讨,并提出相应的改进措施,以期能给高中体育教学改革提供一些参考意见。
金工实习一体化教学改革的一些思路与措施
Authors: 陈 跃 , 周 迅 , 曹 国强
Published: January 2020

金工实习是本科高校培养学生实践能力的重要平台。如何利用金工实习课程培养提高学生的实践能力、应用能力和综合能力,要采取理论和实践有机结合的教学模式,同时调整金工实习教学内容、增加综合项目实训。
小议“犹豫”
Authors: 于 玲利
Published: January 2020

“犹豫”一词,是汉语中的常用词汇,但许多人对其来源却不甚明了。清代以前,学者们从词形的角度训释“犹豫”一词,认为“犹”和“豫”为两种动物。这种说法大约是清代之前被学者广泛接受的一种解释,但实为讹误,“犹豫”为双声联绵词而非合成词。
Capacidades fisiológicas e produção de matéria seca de acessos de batata-doce batata-doce
Authors: Ferreira Evander Alves , Pereira Gustavo Antônio Mendes , Alves Deivide Patrik , Agazzi Luciane Renata Agazzi , Silva Daniel Valadão , Andrade Júnior Valter Carvalho de
Published: January 2020

Existem vários fatores que afetam a fotossíntese, como o déficit físico, o estresse térmico, a concentração de gás interno e externo e a intensidade da luz, no entanto, também pode variar com o material genético ou cultivar avaliado. O objetivo deste estudo foi avaliar as características fisiológicas de setenta e sete genótipos de batata-doce e agrupá-los de acordo com sua produção de matéria fisiológica e seca. Para este fim, foi estabelecido um delineamento de blocos ao acaso (DBC). As características fisiológicas foram coletadas 60 dias após o transplante das mudas de batata-doce nas folhas mais expandidas contadas a partir do meristema apical do ramo mais longo. Foi utilizado um analisador de gás não-infravermelho (IRGA). Com o uso deste dispositivo foi avaliado: a concentração de CO2 (Ci) e a taxa fotossintética (A), a condutância estomática dos vapores de água (Gs), a taxa de transpiração (E), a eficiência do uso da água (EUA) e a proporção Ci / carbono atmosférico (Ci / Ca). Aos 150 dias após o transplante, determinou-se a massa de matéria seca total das plantas (MST). Os genótipos de batata-doce avaliados apresentaram comportamento diferente em relação às diferentes características fisiológicas estudadas. Valores mais elevados de A, Gs, Ci, Ci / Ca e E foram observados em UFVJM-57, mas UFVJM-06 mostrou os valores mais baixos em relação a essas características.
Bioatividade de extratos aquosos de Hedychium coronarium J. Koenig sobre Spodoptera frugiperda J. E. Smith, 1797, (Lepidoptera: Noctuidae)
Authors: Pavarini Gláucia Maria Pereira , Souza Izabella Victoriano de , Pavarini Ronaldo , Coffani-Nunes João Vicente
Published: January 2020

O estudo teve como objetivo avaliar a atividade inseticida dos extratos aquosos da raiz, rizoma, bainha e lâmina foliar da planta Hedychium coronarium J. Koenig, para lagartas do 3° instar de Spodoptera frugiperda J. E. Smith, 1797, considerada principal praga da cultura do milho no Brasil. Os tratamentos consistiram de extratos aquosos das partes vegetais já mencionadas, preparados na concentração de 10% (p/v). Como tratamento controle foi utilizado água destilada. Cubos de dieta artificial de 1cm3 foram mergulhadas nos extratos aquosos e na água por dez segundos sendo em seguida ofertados as lagartas. As características avaliadas foram massa, sobrevivência e duração da fase larval e pupal, massa do inseto adulto e ciclo biológico ovo-adulto. Os extratos aquosos obtidos das partes vegetais de H. coronarium não apresentaram toxicidade à S. frugiperda. Ao contrário do que se esperava, houve estímulo da alimentação quando as lagartas foram submetidas ao extrato aquoso de folhas desta espécie vegetal, apresentando maior massa larval e antecipação do ciclo biológico.
Effects of Mountain Pine Beetle Grey-Stage Infestation and Chip Moisture Content on TMP Pulping of Lodgepole Pine
Authors: HU THOMAS Q. , ZHAO MICHELLE , JOHAL SURJIT , YUEN BERNARD , WATSON PAUL
Published: January 2020

We performed pilot-plant thermomechanical pulping on green and dry, mountain pine beetle-infested, grey-stage lodgepole pine sapwood chips with different moisture contents. The energy requirements and the tensile strength of the thermomechanical pulps (TMPs) from the dry, early-grey-stage chips were similar to those from the green chips, but there were indications of slightly higher energy requirements and lower tensile strength for the pulps from the late-grey-stage chips. The late- or early-grey-stage TMP had lower sheet density (because of the lower chip moisture content), lower ISO brightness, and higher handsheet surface roughness than the green TMP. Chip blends with 50% and 25% of late-grey-stage chips could be used to produce TMP pulps with energy require-ment, tensile strength, handsheet surface roughness, and density similar to those of green TMP, but with lower ISO brightness. The fiber saturation points of the green and the late-grey-stage chips were estimated to be 23.1% and 22.4% (wet basis), respectively.
Refining Energy Reduction and Pulp Characteristic Modification of Alkaline Peroxide Mechanical Pulp (APMP) Through Enzyme Application
Authors: HART PETER W. , WAITE DARRELL M. , THIBAULT, LUC , TOMASHEK JOHN , ROUSSEAU MARIE-EVE , HILL CHRISTOPHER , SABOURIN MARC J.
Published: January 2020

Eucalyptus wood chips were subjected to impregnation with various blends of novel fiber modify-ing enzymes before chemical pretreatment and two stages of refining using the preconditioning refiner chemical–alkaline peroxide mechanical pulping (PRC-APMP) process. Wood chip impregnation and pulp processing was con-ducted at a pilot plant in the United States. When compared under constant chemical application and at a constant 350 mL CSF, enzyme treatment reduced specific refining energy by at least 24%. The effect of one versus two stages of impregnation and of enzyme action upon several physical pulp properties was determined.
Application of Advanced Wet-End System Using Carboxymethyl Cellulose to Mixed Pulp Slurries for Wood-Containing Paper Production
Authors: GONDO TOMOHISA , WATANABE MASASUKE , KITAO OSAMU , ISOGAI AKIRA
Published: January 2020

A pulp modification technique using carboxymethyl cellulose (CMC) at the wet end was applied to mixed pulp slurries containing softwood bleached kraft pulp (SBKP), deinked pulp (DIP), and hydrogen peroxide-bleached thermomechanical pulp (TMP). Introduction of anionic sites by adsorption of the added CMC molecules on the fibers was confirmed by an increase in negative charge of the mixed pulp fibers. Sizing degree of the handsheets prepared with 2% aluminum sulfate and 0.2% rosin dispersion size was clearly improved by 0.1% CMC addition. On the other hand, we observed no significant differences in rosin size content between the handsheets prepared with and without CMC. These results indicate that some mechanisms other than enhancement of rosin size retention may have brought about the clear improvement of sizing performance by the CMC addition. Changes in distribution of rosin size components or some structural changes of rosin size components in the handsheets by the CMC addition may be candidates for sizing development. The CMC addition technique at the wet end is, therefore, also applicable to mixed pulps containing DIP and TMP.
Strategi Komunikasi Pemasaran Hotel Kartika Graha Malang Dalam Meningkatkan Jumlah Pengunjung
Authors: Ekalista Peligia , Tri Hardianto Willy
Published: January 2020

Marketing Communication Strategy is a planning to consume products to targeted markets to achieve the company goals. Through marketing communication strategies, companies try to disseminate information, influence, persuade or remind the target market about a message of the company and its products to be accepted, buy the products offered by the company. This research used descriptive qualitative research. This research was conducted at Hotel Kartika Graha Malang, with a purposive sampling technique with data collection techniques. While the technique of data collection was done by observation, in-depth interviews, and documentation. The data analysis technique used data reduction, data presentation and conclusion withdrawing. The results of this study showed that Kartika Graha Hotel Malang used the IMC theory which implemented Marketing Commucation, Sales Promotion, and Marketing Event and also used the Kotler theory included the marketing mix with four P (4P) namely Product, Price, Place, and Promotion. While the supporting factors in marketing communication strategies were the solid and also the application of elements of marketing communication  maximally  and adequate products and facilities. The inhibiting factors in implementing the marketing communication strategy were the lack of human resources such as driver and technicians that caused clashes with other departments and also budget problems such as the late disbursement from the specified date.
TÜRK MODERNLEŞMESİNİN SERENCAMI
Authors: DURSUNOĞLU İsmail
Published: January 2020

Modernleşme, Batı dünyasının farklı süreçler neticesinde elde ettiği düşünsel paradigma değişikliğidir. Bu değişiklik, dünyayı anlama ve yorumlamada düşünce merkezine aklı yerleştirmedir. Gelenekten kopuşu ifade eden modernizmin sihirli kavramları ise değişim ve ilerlemedir. Çalışmada, Türk modernleşmesinin genel görünümü ele alınmıştır. Bu kapsamda modernleşme başlangıcı, yöntemi, aktörleri ve dinamikleri açıklanmıştır. Çalışmanın amacı, bugün dahi muasır medeniyet seviyesine ulaşma hedefi taşıyan ülkenin, modernleşme sürecinin tartışılmasıdır. Bu tartışma, aslında bir modernleştirme süreci olan dönüşümün ortaya çıkardığı sorunsalı da kapsamaktadır.
Dinamika Tes Peringkat Hafalan
Authors: Aisyah Nur Amalia
Published: January 2020

In addition to the book base, memorization of the Qur'an is also the main base of various Islamic boarding schools in this archipelago. With techniques and methods that have been widely used, one of the typical traditions of rote evaluation carried out by the An-Nur Ngrukem Islamic boarding school is the memorization ranking test. In practice, the memorize ranking tests have various dynamics experienced by female students. This article explains how the dynamics of female students encounter memorized ranking test related to the study of Quran living at the An-Nur Ngrukem Islamic Boarding School. The case study research that forms the basis of this paper, proves the existence of internal and external factors in the dynamics of female students in the face of memorization ranking tests. Among them, internal factors; puberty, mental readiness, tenacity and memorization, and patience. While external factors; need some tips from dzuriyyah and administrators, the strict requirements and conditions of the test, the increasing number of students at the An-Nur Ngrukem Islamic Boarding School and need to manage the time.
Prinsip Komunikasi Al-Qur’an Dalam Menghadapi Era Media Baru
Authors: Isman  Iskandar
Published: January 2020

This research seeks to reconstruct the communication terms in the Qur'an with a more holistic approach. The existing terms all reinforce each other and form a configuration of meanings for the major themes of Islamic communication. At least four domains of Islamic mass media; da'wah, tabligh, amar ma'ruf nahi mungkar and morality (communication, information, change and development, and wisdom). The analysis of key concept communication gave birth to the principle of communication in the face of new media extracted from the values ​​of the Qur'an. The principle is then elaborated in the form of: 1) Communicating in a good way and message 2) Honesty of information and reasonableness 3) Verification of information and responsibility, 4) Inviting to the path of God (Islam) and or contrasting with the best way 5) Anticipating communication disorders and violations.
Solusi Al-Qur’an Terhadap Ujaran Kebencian
Authors: Moh.  Bakir
Published: January 2020

This article wants to explore the Qur'anic view of the utterances of hate with the approach of the theory of maṣlaḥah Najmuddin al-Ṭufi in the book Risālah fī Ri’āyah al-Maṣlaḥah. The author's findings indicate that the Al-Qur'an as a universal scripture emphasizes the importance of safeguarding actions that have the potential to cause noise, conflict, social disintegration and hurt others, both in the form of speech, attitudes, and actions. While the maṣlaḥah according to imam al-Ṭufi is one whose existence gives rise to harmony and does not cause tyranny or harm to anything and anyone. So provocative actions, such as naming, pitting, hoaxes, spreading hate speech and things that can ignite anger from other parties can be suppressed if both pay attention to common concerns. According to him, legally, if an action is clear, the prohibited argument in the text is like the prohibition of cursing, pitting sheep, utterances of hatred, hoax, adultery, gambling, khamar and so on, then the law is forbidden even though these things have a good element for some people especially the culprit.
Glucagon-Like Peptide-1 Analogues Exenatide and Liraglutide Exert Inhibitory Effect on the Early Phase of Liver Regeneration After Partial Hepatectomy in Rats
Authors: FONTANA J. , KUČERA O. , MEZERA V. , ANDĚL M. , ČERVINKOVÁ Z.
Published: January 2020

Glucagon-like peptide-1 (GLP-1) is an incretin known for proliferative and antiapoptotic effects on various tissues. Exenatide and Liraglutide are GLP-1 analogues used in clinical practice as antidiabetic drugs. Since GLP-1 and its analogues exert significant effect on liver metabolism and since changes in intermediary metabolism play an important role in the process of liver regeneration, we decided to determine the effect of Exenatide and Liraglutide on the early phase of liver regeneration and selected metabolic parameters in a model of 2/3 partial hepatectomy (PHx) in rats. Animals were submitted either to PHx or laparotomy and received 3 doses of either GLP-1 analogues (Exenatide – 42 μg/kg b.w., Liraglutide – 0.75 mg/kg b.w.) or saline intraperitoneally. We analyzed body and liver weight, liver bromodeoxyuridine incorporation, liver content of DNA, triacylglycerols and cholesterol and biochemical serum parameters. Bromodeoxyuridine labeling was significantly lower in hepatectomized rats receiving either type of GLP-1 analogues when compared to hepatectomized controls. This effect was more pronounced in the Liraglutide group compared to Exenatide (p<0.001). In addition, liver DNA content was lower in hepatectomized rats receiving Liraglutide than in hepatectomized control rats (p<0.001). In conclusion, GLP-1 analogues Exenatide and Liraglutide significantly inhibited an early phase of liver regeneration after PHx in rats. This inhibitory effect was more pronounced in rats receiving Liraglutide.
The Effect of Very-Low-Calorie Diet on Mitochondrial Dysfunction in Subcutaneous Adipose Tissue and Peripheral Monocytes of Obese Subjects with Type 2 Diabetes Mellitus
Authors: URBANOVÁ M. , MRÁZ M. , ĎUROVCOVÁ V. , TRACHTA P. , KLOUČKOVÁ J. , KAVÁLKOVÁ P. , HALUZÍKOVÁ D. , LACINOVÁ Z. , HANSÍKOVÁ H. , WENCHICH L. , KRŠEK M. , HALUZÍK M.
Published: January 2020

Mitochondrial dysfunction is a potentially important player in the development of insulin resistance and type 2 diabetes mellitus (T2DM). We investigated the changes of mRNA expression of genes encoding main enzymatic complexes of mitochondrial respiratory chain in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM) of 11 subjects with simple obesity (OB), 16 obese patients with T2DM and 17 healthy lean subjects (C) before and after very low-calorie diet (VLCD) using quantitative real time PCR. At baseline in SCAT, both T2DM and OB group had decreased mRNA expression of all investigated mitochondrial genes with the exception of 2 complex I (NDUFA 12) and complex IV (COX 4/1) enzymes in OB subjects. In contrast, in PM only the expression of complex I enzymes NDUFA 12 and MT-ND5 was reduced in both T2DM and OB subjects along with decreased expression of citrate synthase (CS) in T2DM group. Additionally, T2DM subjects showed reduced activity of pyruvate dehydrogenase and complex IV in peripheral blood elements. VLCD further decreased mRNA expression of CS and complex I (NT-ND5) and II (SDHA) enzymes in SCAT and complex IV (COX4/1) and ATP synthase in PM of T2DM group, while increasing the activity of complex IV in their peripheral blood elements. We conclude that impaired mitochondrial biogenesis and decreased activity of respiratory chain enzymatic complexes was present in SCAT and PM of obese and diabetic patients. VLCD improved metabolic parameters and ameliorated mitochondrial oxidative function in peripheral blood elements of T2DM subjects but had only minor and inconsistent effect on mitochondrial gene mRNA expression in SCAT and PM.
Effect of Carcinogen 1,2-Dimethylhydrazine Treatment on Fiber Types in Skeletal Muscles of Male Wistar Rats
Authors: SMERDU V. , PERŠE M.
Published: January 2020

The cancerogen 1,2-dimethylhydrazine (DMH), widely used in the experimental animal model of carcinogenesis, affects various organs, but its effect on muscle fibers is unknown. To evaluate the effect of 15-week DMH treatment on the fiber size and myosin heavy chain (MyHC) isoforms, which substantially determine fiber types and their contractile characteristics, pure and hybrid fiber types were immunohistochemically determined according to the MyHC isoform expression in soleus, extensor digitorum longus, gastrocnemius medialis and lateralis muscles of DMH-treated and control male Wistar rats. Whereas the size of fibers was mostly unaffected, the MyHC isoform expression was partially affected in both gastrocnemius samples, but not in the soleus and extensor digitorum longus of DMH-treated rats. The lower proportions of hybrid fiber types and especially that of type 1/2x in most gastrocnemius samples of DMH-treated rats resulted in a shift towards a single MyHC isoform expression, but the extent and pattern of the MyHC isoform shift varied across the different gastrocnemius samples. Such variable response to DMH treatment across muscles indicates that each muscle possesses its own adaptive range. These findings are essential for an accurate evaluation of skeletal muscle characteristics in DMH animal model.
Glucose Added to a Fat Load Suppresses the Postprandial Triglyceridemia Response in Carriers of the 1131C and 56G Variants of the APOA5 Gene
Authors: ZEMÁNKOVÁ K. , DEMBOVSKÁ R. , PIŤHA J. , KOVÁŘ J.
Published: January 2020

Apolipoprotein A-V plays an important role in the determination of plasma triglyceride (TG) concentration. We aimed to determine whether polymorphisms -1131T>C (rs662799) and 56C>G (rs3135506) of the APOA5 gene have an impact on the course of postprandial lipemia induced by a fat load and a fat load with added glucose. Thirty healthy male volunteers, seven heterozygous for the -1131C variant and three for the 56G variant (HT) carriers, and 20 wild-type (WT) carriers underwent two 8-hour tests of postprandial lipemia – one after an experimental breakfast consisting of 75 g of fat and second after a breakfast consisting of 75 g of fat and 25 g of glucose. HT carriers had a higher postprandial response after fat load than WT carriers (AUC TG: 14.01±4.27 vs. 9.84±3.32 mmol*h/l, respectively, p=0.016). Glucose added to the test meal suppressed such a difference. Heterozygous carriers of the variants of APOA5 (-1131C and 56G) display more pronounced postprandial lipemia after pure fat load than WT carriers. This statistically significant difference disappears when glucose is added to a fat load, suggesting that meal composition modulates the effect of these polymorphisms on the magnitude of postprandial lipemia.