bluuebunny/crossref_metadata_2025 huggingface dataset:
ENCEPHALITIS ANTI N-METHYL-D-ASPARTATE RECEPTORS
Authors: Suryani Shila , Wisudarti Calcarina Retno Fitriani
Published: March 2024

Background : Anti-N-Methyl-D-Aspartate receptor encephalitis is an autoimmune disease where the incidence is still rare which is characterized by complex neuropsychiatric syndrome. In severe stages, it can cause morbidity and mortality so it requires adequate intensive therapeutic management. Cases: 1) Male, 23 years old diagnosed with NMDAR encephalitis at an advanced stage in 10 days of treatment. Patient was given plasma exchange therapy three times and steroids did not respond then given rituximab, did not respond as expected. 2) A 19-year-old male diagnosed with NMDAR encephalitis at an advanced stage on the 7th day of hospitalization. Patient was given plasma exchange therapy 7 times and steroids. The patient showed an improved response to the third plasma exchange therapy, the patient could weaned from the ventilator and then transferred from the ICU. Conclusion: NMDAR encephalitis at an advanced stage requires long intensive care. Immunotherapy is the first-line therapy for NMDAR encephalitis. Immunotherapy options in severe cases can be given plasma exchange in combination with steroids. Rapid diagnosis and early initiation of therapy can provide better outcomes, reduce complications of nosocomial infections and reduce length of stay in the ICU.
KORELASI ANTARA USIA DAN LAMA MENDERITA HIPERTENSI DENGAN FUNGSI KOGNITIF PADA PESERTA PROLANIS HIPERTENSI DI SUMBANG
Authors: Agustin Rahma Rizki , Kuncoro Prasetyo Tri , Harini Ika Murti , Pramudigdo Muttaqien , Setiawan Agus Budi
Published: March 2024

Hipertensi merupakan kondisi peningkatan tekanan darah sistolik dan diastolik (≥140/≥90 mmHg). Salah satu dampak dari hipertensi adalah penurunan fungsi kognitif. Lama seseorang menderita hipertensi menjadi salah satu faktor yang dapat mempengaruhi fungsi kognitif. Penelitian ini bertujuan untuk mengetahui korelasi antara usia dan lama menderita hipertensi dengan fungsi kognitif pada peserta prolanis hipertensi di salah satu Klinik Pratama yang ada di Kecamatan Sumbang. Jenis penelitian yang dilakukan bersifat observasional analitik dengan pendekatan cross-sectional yang dilakukan pada kegiatan prolanis hipertensi di Klinik Pratama Sumbang. Pengambilan sampel diperoleh dari data primer berupa kuesioner Montreal Cognitive Assessment versi Indonesia (MoCA-Ina). Populasi pada penelitian ini menggunakan total sampling yaitu sebanyak 33 sampel peserta prolanis hipertensi. Teknik analisis data menggunakan uji Chi-square. Dihasilkan bahwa dari 33 penderita hipertensi dengan usia 45-60 tahun sebanyak (45,5%), dan yang berusia 61-75 tahun sebanyak (54,5%). Sebagian besar responden menderita hipertensi >5 tahun sebanyak (51,5%), dan terdapat (66,7%) responden yang mengalami penurunan fungsi kognitif. Analisis bivariat uji Chi-square antara usia dengan fungsi kognitif diperoleh nilai p value = 0,007 (p>0,05) yang menunjukkan terdapat hubungan yang bermakna; lama menderita hipertensi dengan fungsi kognitif diperoleh nilai p value = 0,026 (p>0,05) yang menunjukkan terdapat hubungan yang bermakna. Terdapat hubungan yang bermakna antara usia dengan fungsi kognitif pada peserta prolanis di Klinik Pratama Sumbang; terdapat hubungan yang bermakna antara lama menderita hipertensi dengan fungsi kognitif pada peserta prolanis di Klinik Pratama Sumbang.
FAMILY PERCEPTION OF LIFE-SUSTAINING TREATMENT WITHDRAWAL IN PATIENT WITH SEVERE BRAIN INJURY: A QUALITATIVE STUDY IN BANDUNG-INDONESIA
Authors: Hidayat Gezira Azka Aulia , Huspa Fitri Agustina , Syukriani Yoni Fuadah
Published: March 2024

Background: The decision-making process for withdrawing life-sustaining treatment (LST) in patients with severe brain injury can potentially become a problem between doctor and family because of different opinions.
 
Objective: Explore the family consideration in withdrawing LST in patients with severe brain injury.
 
Methods: This qualitative descriptive study with phenomenological approach conducted using semi-structured in-depth interview. Subjects were family members of coma patients due to severe brain injury and were admitted to the Intensive Care Unit in Hasan Sadikin General Hospital during January 2019 - December 2020.
 
Results: The results of the five-participant interview showed that the considerations for withdrawing LST include: (1) the patient's condition, (2) family psychology, (3) resources, and (4) family beliefs.
 
Conclusion: Doctors need to understand the family's considerations in terminating LST to bridge the inner conflicts that occur in the patient's family.
Penentuan Sebab Kematian Diduga Keracunan Fungisida Mancozeb Berdasarkan Pemeriksaan Histopatologi Pada Jenazah Busuk
Authors: Hidayat Taufik
Published: March 2024

Peningkatan kejadian kasus pembunuhan maupun bunuh diri menggunakan racun terjadi dari tahun ke tahun. Pembuktian sebab kematian karena racun membutuhkan analisis forensik yang dalam terkait efek racun terhadap organ tubuh manusia. Dilaporkan penemuan jenazah laki-laki dewasa dalam keadaan busuk dipenuhi belatung di sebuah kebun teh. Pada pemeriksaan luar ditemukan luka bakar derajat 2 seluas 19% di area bokong, genitalia dan perut bawah.Memar pada kulit puncak kepala. Organ dalam keadaan busuk.Pada pemeriksaan histopatologi ditemukan kongesti dan perdarahan pada jantung, hati, limpa, ginjal dan paru. Ditemukan aterosklerosis koroner, fatty change, edema pulmonum, glomerulosklerosis dan tubular atrophy. Pemeriksaan entomologi ditemukan larva instar 2 dan instar 3 darifamily Calliphoridae. Disimpulkan sebab kematian akibat racun yang menyebabkan asfiksia (matilemas) dan terdapat penyakit menahun pada jantung dan ginjal.
Kata kunci : pembusukan, racun, sebabmati
CHARACTERISTICS VISUM ET REPERTUM OF LIVE VICTIMS AT BHAYANGKARA POLDA DIY HOSPITAL (2014-2016)
Authors: Eko Andhiriawan , Utami Handayani Dwi , Siswoputro Andy Yok
Published: March 2024

ABSTRAK
Latar Belakang : RS.Bhayangkara POLDA DIY adalah salah satu RS yang melayani pemeriksaan klinis dan membuat laporan visum et repertum.  Di dalamnya terdapat karakteristik yang dapat diamati.
Tujuan : Melihat karakteristik VeR hidup RS. Bhayangkara POLDA DIY 01 Januari 2014-31 Desember 2016
Metode :  Deskriptif retrospektif crossectional dengan metode total sampling.
Hasil dan Pembahasan : Data VeR hidup selama 3 tahun berjumlah 46 dokumen yang terbagi : 10 (2014), 7  (2015), dan 29 (2016). Jenis : 28  perlukaan, 18 susila, 0 psikiatrik. Penyebab luka : 4 fisik, 23 mekanik, dan 1 zat kimia. Usia terbanyak 22-40, paling sedikit 0-5 tahun. Jenis kelamin : 25 lelaki dan 21 perempuan. Derajat luka : 17 (derajat 1), 7 (derajat 2), dan 4 (derajat 3). Derajat 1, derajat luka terbanyak  (70 %). 22-40 tahun,usia terbanyak (40 %).Waktu terbanyak, bulan Februari (11) dan paling sedikit Juli. Wilayah terbanyak, Polda DIY (11). Ditreskrimmum Polda DIY, wilayah paling banyak (30 %). Lelaki, jenis kelamin terbanyak (55 %).
Kesimpulan : Jumlah VeR hidup terbanyak, tahun 2016 (61 %). Jenis terbanyak adalah VeR perlukaan, (65 %). Kekerasan mekanik adalah penyebab luka terbanyak (88 %).
Kata Kunci : Karakteristik, Visum et Repertum Hidup, RS.Bhayangkara POLDA DIY.
Pemberdayaan Masyarakat Desa Jatisari Kabupaten Boyolali Melalui Pengolahan Nata Ubi Jalar Ungu (Ipomoea batatas)
Authors: Sofyan Aan , Zulfah Dewi Nashikhatul , Mandasari Anita , Zuhri Thoha Syaifudin
Published: March 2024

Community empowerment can create self-sufficiency in various fields, both in the economic and food fields. The people of Jatisari Village who are members of the PKK have the potential to process various food products including nata made from purple sweet potato extract (Ipomoea batatas). The purpose of this service program is to provide knowledge and skills to the community about the technology for making nata made from purple sweet potato extract with the addition of red beans (Phaseolus vulgaris) as a nitrogen source in the fermentation process. The benefits of this service are that it can provide knowledge and skills in processing and making nata made from purple sweet potato extract. The method of implementing the service program consists of several stages, including the preparation stage, problem identification, pretest, workshop, workshop, posttest, and evaluation. The results of the implementation of the service program show that members of the Jatisari Village PKK have attended training in making nata made from purple sweet potato extract starting from the process of preparing raw materials, concocting various ingredients, to the process of preparing fermentation to produce nata. The evaluation results showed that most of the training participants did not know how to make nata. In addition, the participants also had never practiced making nata, so this dedication program to introduce nata-making technology could add to the knowledge and experience of PKK Jatisari Village members.
Atomic Structure and Binding of Carbon Atoms
Authors: Ali Mubarak
Published: March 2024

Carbon exhibits complex behavior due to several allotropes. Processing carbon precursors by different techniques and methods results in various carbon materials. However, the characterizations and analyses of processed carbon materials in any form do not keep up to the mark discussions. There are many uncertainties. First, there is a need to study each carbon allotropic form separately and then the binding of same-state atoms. Depending on the processing conditions of a carbon precursor, the state of the carbon atom changes. The conversion of the carbon atom from one state to another is due to the electron transfer mechanism. The bits of energy with shape-like dashes transfer electrons to nearby unfilled states during the state conversion of a carbon atom. The involved dash-shaped energy bit maintains partially conserved behavior. Atoms in the graphite state also study a one-dimensional structure under the execution of electron dynamics. There is a two-dimensional structure in nanotube atoms and a four-dimensional structure in fullerene atoms. If the diamond atoms bind, the outer ring electrons of the depositing diamond atom undertake an additional clamp of the outer ring energy knot of the deposited diamond atom. Binding in the diamond atoms occurs from the surface (east-west) to the south. Therefore, the growth of the diamond structure occurs from the south to the surface (east-west). Golf-stick-shaped energy bits bind the diamond, lonsdaleite, or graphene state atoms into their structures. In a glassy carbon structure, the layers of gaseous, graphitic, and lonsdaleite atoms bind simultaneously. The layers repeat in order during the growth process of glassy carbon. The hardness of the processed material in each state of carbon provides new insight. This study aimed to understand the fundamental and applied science of carbon atoms and their binding to structures.
On Fuzzy Soft Beta-Continuity and Beta-Irresoluteness: Properties and Applications
Authors: Alshammari Ibtesam , Taha Islam M.
Published: March 2024

In the present study. At first, some properties of r-fuzzy soft β-closed sets are introduced on fuzzy soft topological spaces based on the paper Aygunoglu et al. (Hacet. J. Math. Stat. 2014, 43, 193-208). Also, we define the closure and interior operators with respect to the classes of r-fuzzy soft β-closed and r-fuzzy soft β-open sets, and investigate some of their properties. In addition, the concept of r-fuzzy soft β-connected sets is introduced and characterized with help of fuzzy soft β-closure operators. Thereafter, some properties of a fuzzy soft β-continuity are studied. Furthermore, we introduce and study the concepts of fuzzy soft almost (weakly) β-continuous functions, which are weaker forms of a fuzzy soft β-continuity. Also, the relationships between these classes of functions are specified with the help of some illustrative examples. Finally, we explore new types of fuzzy soft functions called, fuzzy soft β-irresolute (strongly β-irresolute, β-irresolute open, β-irresolute closed and β-irresolute homeomorphism) functions, and discuss some properties of them. Also, we show that fuzzy soft strongly β-irresolute → fuzzy soft β-irresolute → fuzzy soft β-continuity, but the converse may not be true.
Magnetic Black Hole Thermodynamics in an Extended Phase Space with Nonlinear Electrodynamics
Authors: Kruglov S. I.
Published: March 2024

We study Einstein's gravity coupled to nonlinear electrodynamics with two parameters in Anti-de Sitter spacetime. Magnetically charged black holes in an extended phase space is investigated. We obtain the mass and metric functions, their asymptotic and corrections to the Reissner--Nordstr\"{o}m metric function when the cosmological constant vanishes. The first law of black hole thermodynamics in extended phase space is formulated and the magnetic potential and the thermodynamic conjugate to the coupling are obtained. We proved the generalized Smarr relation. The heat capacity and the Gibbs free energy are computed and phase transitions are studied. It was shown that the electric field of charged objects at the origin and electrostatic self-energy are finite within the nonlinear electrodynamics proposed.
Insights into Corporate Tax Evasion and Its Ramifications on Overall Budget Revenue: An Empirical Study
Authors: Abu Huson Yazan , Almousa Mousa , Alqudah Mohammad
Published: March 2024

This paper addresses the pressing concern of corporate tax evasion recognized by several nations, employing insights from public choice theory and tax compliance theory. The research aims to evaluate the ramifications of corporate tax evasion on public revenue, public expenditures, tax rates, and the prevailing budget deficit. Methodologically, the study utilizes questionnaire data and employs structural equation modeling for analysis. The findings indicate that tax evasion is significantly influenced by multiple factors, encompassing tax income, public expenditures, tax rates, and the budget deficit. The article offers a comprehensive exploration of both theoretical frameworks and practical implications, contributing valuable insights to the ongoing discourse on corporate tax evasion and its multifaceted impact on fiscal dynamics.
Genomic and Phenotypic Analysis of Salmonella enterica Bacteriophages Identifies Two Novel Phage Species
Authors: Bhandare Sudhakar , Lawal Opeyemi U. , Colavecchio Anna , Cadieux Brigitte , Zahirovich-Jovich Yella , Zhong Zeyan , Tompkins Elizabeth , Amitrano Margot , Kukavica-Ibrulj Irena , Boyle Brian , Wang Siyun , Levesque Roger C. , Delaquis Pascal , Danyluk Michelle , Goodridge Lawrence
Published: March 2024

Bacteriophages (phages) are potential alternatives to chemical antimicrobials against pathogens of public health significance. Understanding the diversity and host specificity of phages is important for developing effective phage biocontrol approaches. Here, we assessed the host range, morphology, and genetic diversity of eight Salmonella enterica phages isolated from a wastewater treatment plant. The host range analysis revealed that six out of eight phages lysed more than 81% of the 43 Salmonella enterica isolates tested. The genomic sequences of all phages were determined. Whole genome sequencing data (WGS) data revealed that phage genome sizes ranged from 41 to 114 kb with GC contents be-tween 39.9 and 50.0 %. Two of the phages SB13 and SB28 represent new species Epsep-timavirus SB13 and genera Macdonaldcampvirus, respectively as designated by the In-ternational Committee for the Taxonomy of Viruses (ICTV) as per genome based taxonomic classification. One phage (SB18) belonged to the Myoviridae morphotype while the re-maining phages belonged to the Siphoviridae morphotype. The gene content analyses showed that none of the phages possessed virulence, toxin, antibiotic resistance, type I-VI toxin-antitoxin modules or lysogeny genes. Three (SB3, SB15 and SB18) out of the eight phages possessed tailspike proteins. Whole genome-based phylogeny of the eight phages with their 113 homologs revealed three clusters A, B, C and seven subclusters (A1, A2, A3, B1, B2, C1 and C2). While cluster C1 phages were predominantly isolated from animal sources, cluster B contained phages from both wastewater and animal sources. The broad host range of these phages highlights their potential use to control the presence of S. enterica in foods.
Analyzing the impact of Resistant Starch Formation in Basmati Rice Products: Exploring Associations with Blood Glucose and Lipid Profiles across various cooking and storage conditions
Authors: Kaur Prabhjot , Kaur Harpreet , Aggarwal Renuka , Bains Kiran , Kaur Amrit , Singla Lachhman Das , Gupta Kuldeep
Published: March 2024

Background/objectives: The health benefits of resistant starch are well known, but there have not been many studies available documenting the effect of basmati rice products containg resistant starch upon blood glucose level and lipid profile in vivo efficacy. Methods: Common cooking methods were used to prepare basmati rice products including two boiling methods viz. boiling 1 (boiling by absorption), boiling 2 (boiling in extra amount of water), frying and pressure cooking. The cooked rice were held at various temperatures and times: it was made fresh (T1), kept at room temperature (20–22°C) for 24 h (T2), kept at 4°C for 24 h (T3), and then reheated after being kept at 4°C for 24 h(T4). Next, the products' proximate composition, total dietary fibre (soluble and insoluble), resistant starch (RS), and In vitro starch digestion rate (rapidly and slowly digested starch) were examined. The effect of RS on blood glucose and lipid profile were measured in humans and rats. Histopathological study of liver and pancreas in rats were also observed. Results: The basmati rice prepared by boiling 1 and stored with T3 was found more effective to control blood glucose and lipid profile. Similarly in rats, the blood glucose level, cholesterol, triglycerides and LDL were reduced about 29.7, 37.9, 31.3 and 30.5% respectively, after consumption of basmsti rice prepared by boiling 1 and stored at T3. Conclusion: Rice products stored at 4⁰C have a high amount of resistant starh, insoluble dietary fibre, slowly digestible starch and low glycemic index. Thus helps to inhibit glycogen and lipid synthesis.
In the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Kruppel-Like Family of Transcription Factors
Authors: Garcia-Loredo Juan Andres , Santoyo-Suarez Michelle G. , Rodríguez-Nuñez Oscar , Benitez Chao Diego Francisco , Garza-Treviño Elsa N. , Zapata-Morín Patricio Adrián , Padilla-Rivas Gerardo R. , Islas Jose Francisco
Published: March 2024

The CACCC-box motif emerges as a pivotal cis-regulatory element implicated in diverse developmental processes and diseases, particularly cardiovascular diseases (CVDs). This study centers on the intricate interplay between the CACCC-box and its binding proteins such as: the Krüppel-like family (KLF) of transcription factors as primary effectors in the context of CVDs. Our analysis was through a bioinformatics approach, which reveal significant transcriptional activity among KLF subgroup 2, exhibiting the highest number of interactions focusing on the established roles: pluripotency, cancer, and cardiovascular development and diseases. Our analysis reveals KLF's interactions with GATA4, MEF2C, NKX2.5 and other ~ 90 potential genes that participate in the regulation of the hypertrophic environment (or CVD's Environment). Also, the GO analysis showed genes containing the motif CACCC were enriched for multiple CVD’s, in combination with STRING analysis these results pointed to a link between KLFs and these diseases. The analysis further identifies other potential CACCC-box binding factors, such as SP family members, WT1, VEZF1, and -SALL4, which are implicated in cardiac contraction, remodeling, and inflammation processes.
Cholinergic Stimulation Exerts Cardioprotective Effects and Alleviates Renal Inflammatory Responses after Acute Myocardial Infarction in Spontaneous Hypertensive Rats (SHRs)
Authors: Bricher Choque Pamela Nithzi , Porter Maria Helena , Teixeira Manuella da Silva , Dellê Humberto , Elias Rosilene Motta , Durante Bruno , Dutra Marina Rascio Henriques , Metz Christine N. , Pavlov Valentin A. , Consolim Colombo Fernanda M.
Published: March 2024

Background: In this investigation, we explored the effects of pharmacological cholinergic stimulation on cardiac function and renal inflammation following acute myocardial infarction (AMI) in spontaneously hypertensive rats (SHRs). Methods: Adult male SHRs were randomized into three experimental groups: sham-operated; AMI+Veh (infarcted, treated with vehicle); and AMI+PY (infarcted, treated with the cholinesterase inhibitor pyridostigmine bromide (PY) - 40 mg/kg, once daily for seven days). Rats were euthanized 7 or 30 days post-surgery. Clinical parameters were assessed on the day before euthanasia. Subsequent to euthanasia, blood samples were collected and renal tissues were harvested for histological and gene expression analyses aimed to evaluate inflammation and injury. Results: Seven days post-surgery, the AMI+PY group demonstrated improvements in left ventricular diastolic function and autonomic regulation, and a reduction in renal macrophage infiltration compared to the AMI+Veh group. Furthermore, there was a notable downregulation of pro-inflammatory gene expression and an upregulation of anti-inflammatory gene expression. Analysis 30 days post-surgery showed that PY treatment had a sustained positive effect on renal gene expression, correlated with a decrease in biomarkers indicative of subclinical kidney injury. Conclusion: Short-term cholinergic stimulation with PY provides both cardiac and renal protection by mitigating the inflammatory response after AMI.
Human Vault RNAs–Small Molecules and Great Perspectives. The Insight on Their Role in Cellular Metabolism
Authors: Taube Magdalena , Lisiak Natalia , Totoń Ewa , Rubiś Błażej
Published: March 2024

Non-coding RNAs have been described as crucial regulators of gene expression and guards for cellular homeostasis. Some recent papers are focused on vault RNAs, one of the classes of non-coding RNA, and their role in cell proliferation, tumorigenesis, apoptosis, cancer response to therapy, and autophagy, which made them potential therapy targets in oncology. In the human genome, four vault RNA paralogues can be distinguished. They are associated with vault complexes, considered the largest ribonucleoprotein complex. The protein part of these complexes consists of a major vault protein (MVP) and two minor vault proteins (vPARP and TEP1). The name of the complex, as well as vault RNA, comes from the hollow barrel-shaped structure that reminds a vault. Their sequence and structure are highly evolutionary conserved and show many similarities in comparison with different species, but vault RNAs show various roles. Vaults were discovered in 1986, and their functions remained unclear for many years. Although not much is known about their contribution to cell metabolism, it has become clear that vault RNAs are involved in various processes and pathways associated with cancer progression and modulating cell functioning in normal and pathological stages. In this review, we discuss known functions of the human vault RNAs in the context of cellular metabolism, emphasizing processes related to cancer and cancer therapy efficacy.
The Jacobian Conjecture and Idempotent Ideals
Authors: Matysiak Lukasz
Published: March 2024

In this paper we present two ways to solve the Jacobian conjecture. The first way is an equivalent statement to the Jacobian conjecture using idempotent ideals. The second way is to use an equivalent thesis to the thesis of the Jacobian conjecture. In both cases we will show that the Jacobian conjecture is true.
Assessment of Postbiotic, Mundticin-like Substance EM 41/3 Application in Broiler Rabbits
Authors: Lauková Andrea , Chrastinová Ľubica , Focková Valentína , Plachá Iveta , Bino Eva , Grešáková Ľubomira , Formelová Zuzana , Žitňan Rudolf , Belzecki Grzegorz , Miltko Renata , Pogány Simonová Monika
Published: March 2024

Nowadays, animal breeders look for effective innovations to care animal health. Use of probiotics, postbiotics, parabiotics and the other beneficial natural substances are dominated. Mundticin-like substance EM 41/3 is thermo-stable bacteriocin (postbiotic) with a broad antimicrobial spectrum. In this study its effect in broiler rabbits was assessed. Rabbits represent food-derived animal and they are also suitable animal model. The parameters tested were analyzed by validated methods. Administration of MLS EM 41/3 produced by non-autochthonous strain Enterococcus mundtii EM 41/3 lead to significant increase of parameter immunity-phagocytic activity, while it did not influence microbiota composition. It also did not influence blood biochemistry and no oxidative stress was noted. Moreover, higher growth parameters were noted and also stimulated hydrolytic activity. Finally, no negative influence on rabbit meat quality was noted. Postbiotic MLS EM 41/3 administration in feeding strategy seems to be contributing fact for rabbit health status maintaining.
ML Based Software Defect Prediction in Embedded Software for Telecommunication Systems(Focusing on the Case of SAMSUNG ELECTRONICS)
Authors: Kang Hongkoo , Do Sungryong
Published: March 2024

Software stands as one of the most rapidly evolving technologies in the present era, characterized by its swift expansion in both scale and complexity which leads to challenges in quality assurance. Software Defect Prediction (SDP) emerges as a methodology crafted to anticipate undiscovered defects, leveraging known defect data from existing codes. This methodology serves to facilitate software quality management, thereby ensuring overall product quality. Machine Learning (ML) and Deep Learning (DL) methodologies exhibit superior accuracy and adaptability compared to traditional statistical approaches catalyzing active researches in this domain. However, it makes us hard to generalize not only because of the disparity between open-source project and commercial project but also the difference on each industrial sectors. Consequently, further research utilizing datasets sourced from diverse real-world sectors becomes imperative to bolster the applicability of these findings. In this study, we utilized embedded software for telecommunication systems of SAMSUNG ELECTRONICS, supplemented by the introduction of nine novel features to train the model, and subsequent analysis of results ensued. Experimental outcomes revealed that the F-measurement metric has been enhanced from 0.58 to 0.63 upon integration of the new features, thereby signifying a performance augmentation of 8.62%. This case study is anticipated to contribute to bolster the application of SDP methodologies within analogous industrial sectors.
New Infinite Classes for Normal Trimagic Squares of Even Orders Using Row-Square Magic Rectangles
Authors: Hu Can , Pan Fengchu
Published: March 2024

As matrix representations of magic labelings of related hypergraphs, magic squares and their various variants have been applied to many domains. Among various subclasses, trimagic squares have been investigated for over a hundred years. The existence problem for trimagic squares with singly even orders and orders 16n has been solved completely. However, very little is known for the existence of trimagic squares with other even orders except for the only three examples and three families. We construct normal trimagic squares by using product constructions, row-square magic rectangles, and trimagic pairs of orthogonal diagonal Latin squares. We give a new product construction: For positive integers p, q, and r having the same parity other than 1, 2, 3, 6, if normal p × q and r × q row-square magic rectangles exist, then a normal trimagic square with order pqr exists. As its application, we construct normal trimagic squares of orders 8q^3 and 8pqr for all odd integers q not less than 7 and p,r ∈ {7, 11, 13, 17, 19, 23, 29, 31, 37}. Our construction can easily be extended to construct multimagic squares.
miR-1 as a Key Epigenetic Regulator in Early Differentiation of Cardiac Sinoatrial Region
Authors: García-Padilla Carlos , Lozano-Velasco Estefanía , García-López Virginio , Aránega Amelia , Franco Diego , García-Martínez Virginio , López-Sánchez Carmen
Published: March 2024

A large diversity of epigenetic factors, such as microRNAs and histones modifications, are known to be capable of regulating gene expression without altering DNA sequence itself. In particular, miR-1 is considered the first essential microRNA in cardiac development. In this study, miR-1 potential role in early cardiac chamber differentiation is analyzed through specific signaling pathways. For this, we performed in chick embryos functional experiments by means of miR-1 microinjections into the posterior cardiac precursors -of both primitive endocardial tubes- committed to sinoatrial region fates. Subsequently, embryos were subjected to whole mount in situ hybridization, immunohistochemistry and RT-qPCR analysis. As a relevant nov-elty, our results revealed that miR-1 increases Tbx5, Gata4 and AMHC1, while this microRNA diminishes Mef2c expression, during early differentiation of cardiac sinoatrial region. Further-more, we observed in this developmental context that miR-1 upregulates CRABPII and RARß, and downregulates CRABPI, which are three crucial factors in retinoic acid signaling pathway. Interestingly, we also noticed that miR-1 directly interacts with HDAC4 and Calmodulin, as well as with Erk2/MAPK1, which are three key factors actively involved in Mef2c regulation. Our study shows, for the first time, a key role of miR-1 as an epigenetic regulator in early differenti-ation of cardiac sinoatrial region through orchestrating opposite actions between retinoic acid and Mef2c, fundamental to properly assign cardiac cells to their respective heart chambers. A better understanding of those molecular mechanisms modulated by miR-1 will definitely help in fields applied to therapy and cardiac regeneration and repair.
Exploring Scientific Management in County Departments of Sports and Youth (CDYS) in Romania: Insights, Challenges, and Pathways Forward
Authors: Dragoș Gheorghe Cristian , Muntean Raul Ioan
Published: March 2024

The purpose of this article is to investigate and analyze the practices of scientific management within the County Departments of Sports and Youth (CDYS) in Romania. Conducted through a comprehensive research endeavor spanning from January to June 2022, the study utilized a standardized questionnaire as its primary instrument for data collection, distributed among CDYS directors. A notable finding from the study indicates that a significant proportion of respondents (44.9%) perceive notable disparities in the normative-functional elements governing the National Sports System in Romania compared to international standards. Moreover, the majority (51%) consistently adhere to regulatory acts, while a substantial portion (69.4%) underscore the importance of strict adherence to internal regulations in strategy formulation. Furthermore, an overwhelming majority (88.9%) acknowledge the substantial influence of available resources on strategy development, with collaboration with authorities primarily occurring through direct communication channels. Respondents prioritize multiple objectives (44.9%), affirm the necessity of various competencies (53.1%), and identify a lack of human and financial resources (59.2%) as the most significant obstacle. Notable achievements highlighted in the study include the improvement of the county's sports performance (53.1%). Respondents also believe that setting clear and realistic objectives (38.8%) is pivotal to enhancing CDYS management, while considerations in formulating strategies emphasize trends in the sports domain (42.9%) and the specific needs of the local sports community (42.9%). Overall, this research contributes to the understanding and promotion of more efficient practices in managing sports and youth departments within Romania's counties.
Epidemiological Study on a Wilson Disease Group of Patients
Authors: Moraru Liviu , Budianu Mihaela-Alexandra , Musteață Isabela-Raluca , Voidazan Toader Septimiu
Published: March 2024

Background and Objectives: Wilson disease (WD) is a disorder of copper metabolism caused by genetic muta-tions in the ATP7B gene which lead to the accumulation of copper in the body. The aim of the present study is to investigate the severity of WD in patients in Romania. Materials and Methods: This study was conducted us-ing an online questionnaire consisting of 32 questions in a group of patients suffering from Wilson disease. Results: The study included 67 people aged 7 to 56 with WD. The most common symptoms of the participants were hepatic and neurological in 22 cases (32.8%). The most common neurological symptom in the assessed cases was muscle stiffness (49.5%), followed by tremor (45%), and speech disorders (40.5%). The Kay-ser-Fleischer ring was present in 50.7% of the participants. The most commonly used drug treatment in the participants was D-penicillamine (77.61%). Conclusions: The severity of WD is based on many aspects, the most important being early diagnosis and access to treatment throughout the year. The prognosis is favorable with early diagnosis and treatment, but it is crucial to diagnose individuals before they develop major symp-toms. Therefore, advances in WD screening can lead to an earlier diagnosis and better results.
Growth Performance of Buffalo Calves in Response to Different Diets with and without Saccharomyces cerevisiae Supplementation
Authors: Zicarelli Fabio , Musco Nadia , Iommelli Piera , Wanapat Metha , Lotito Daria , Lombardi Pietro , Infascelli Federico , Tudisco Raffaella
Published: March 2024

The aim of the present trial was to evaluate the growth performance of buffalo calves fed diets characterized by different forage/concentrate ratio with or without the Saccharomyces Cerevisiae supplementation (CBS 493.94, Yea-Sacc®). Twenty-four male buffalo calves (mean age 145.1 ± 16.1 days; mean weight 108.0 ± 18.7) were assigned randomly to 4 groups, homogeneous for age, fed four different diets: diet 1 F:C ratio 50:50; diet 2 F:C ratio 30:70; diet 3 F:C ratio 50:50 + Yea-Sacc® and diet 4 F:C ratio 30:70 + Yea-Sacc®. Buffalo calves were individually weighted before the start of the experiment and the data were used as a covariate, monthly until the end of the trial. Dry matter intake (DMI), daily weight gain (DWG) and feed conversion ratio (FCR) were calculated. The differences in diets’ composition significantly (p
Mechanics 4.0 and Mechanical Engineering Education
Authors: LOPEZ EUSEBIO JIMENEZ , LEYVA PABLO ALBERTO LIMÓN , López Armando Ambrosio , Estrella Francisco Javier Ochoa , Vázquez Juan José Delfín , Vázquez Baldomero Lucero , Molina Víctor Manuel Martínez
Published: March 2024

Industry 4.0 is an industrial paradigm that is causing changes in form and substance in factories, companies and businesses around the world, and is impacting work and education in general. In fact, the disruptive technologies that frame the fourth industrial revolution have the potential to improve and optimize manufacturing processes and the entire value chain, which can lead to an exponential evolution in the production and distribution of goods and services. All these changes imply that the fields of engineering knowledge must be oriented towards the concept of Industry 4.0, for example Mechanical Engineering. The development of various physical assets that are used by cyber-physical systems and digital twins is based on Mechanics. However, the specialized literature on Industry 4.0 says little about the importance of Mechanics in the new industrial era and more importance is given to the evolution of Information and Communication Technologies and Artificial Intelligence. This article presents a frame of reference about the importance of Mechanical Engineering in Industry 4.0 and proposes an extension to the concept of Mechanics 4.0, recently defined as the relationship between Mechanics and Artificial Intelligence. For the analysis of Mechanical Engineering in Industry 4.0, the criteria of the four driving forces that defined Mechanics in the third industrial revolution was used. An analysis of Mechanical Engineering Education in Industry 4.0 is presented, and the concept of Mechanical Engineering 4.0 Education is improved. Finally, the importance of making changes in the educational models of engineering education is described.
Impacts of Climate Change on agriculture in Angola: analysis of agroclimatic and bioclimatic indicators
Authors: Correia Carlos Domingos Ndala Correia , Amraoui Malik , Santos João Carlos Andrade
Published: March 2024

Angola is vulnerable to climate change, as most of its agriculture is rain-fed and repre-sents the backbone of the people of the southern region of the country, and many peo-ple’s livelihoods depend on it. All crops can suffer from the impacts of climate change, which can lead to challenges in agricultural production and food security in different regions of the world. The work consisted of a systematic review of the impacts of climate change on agriculture in Angola, particularly in the southern region. To achieve this objective the PRISMA2020 methodology was used, using the flowcharts for the selection of studies evaluated from the databases that are: Scopus and Web Sci-ence, resulting in 431 documents published between 1996 and 2023, and of these only 63 were included in the systematic review, with inclusion and exclusion criteria. Research on the short and long-term effects of climate change impacts in agriculture in Angola and in particular the southern region is scarce and insufficient. Temperatures are pre-dicted to rise and precipitation generally decreases over time (approximately -2% by 2100), with the southern region experiencing a stronger drop in precipitation. Agri-culture in Angola will be hit hard and some models show that agricultural productiv-ity will be up to 7% lower by 2050 owing to climate change.
Application of Carbon Fiber Microelectrode as a Sensor for Apocynin Electroanalysis
Authors: Michalkiewicz Slawomir , Skorupa Agata , Jakubczyk Magdalena , Bębacz Karolina
Published: March 2024

In this study, a carbon fiber microelectrode (CF) was applied for the investigation of electrochemical behavior and determination of natural antioxidant, apocynin (APO). Given the limited solubility of APO in water, a mixture of anhydrous acetic acid (AcH) with 20%, v/v acetonitrile (AN) and 0.1 mol L-1 sodium acetate (AcNa) was used. The electrochemical properties of APO were examined through linear sweep voltammetry (LSV), differential pulse voltammetry (DPV), and cyclic voltammetry (CV). The anodic oxidation of APO, which is the basis of the method used, proved to be diffusion-controlled and proceeded with a two-electron and one proton exchange. Both radicals and radical cations, arising from the first and second step of electrode reactions, respectively, underwent subsequent chemical transformations to yield more stable final products (EqCiEiCi mechanism). Using optimized DPV conditions, the anodic peak current of APO at potential of 0.925 V vs Ag/AgCl showed a good linear response within the concentration range of 2.7×10-6 – 2.6×10-4 mol L-1. The detection and quantification limits were determined as 8.9×10-7 and 2.7×10-6 mol L-1, respectively. The developed DPV method enabled the successful determination of APO in herbal extracts and in dietary supplements. It should be noted that this is the first method of voltammetric determination of APO.
Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
Authors: Sandler Niklas , Shokraneh Farnaz , Bahman Mahsa , Lahtinen Julius , Hassinen Niko , Airaksinen Sari , Verma Soumya , Hrizanovska Ludmila , Lass Jana , Heinämäki Jyrki , Paaver Urve , Karlstedt Anssi , Tähnas Janika , Klaas Christoph , Kern Catharina , Bienfait Adeline , Lagarce Frédéric , Fenske Dominic , Muehlenfeld Katrin , Malik Julia , Scherliess Holger , Ojala Samuli , Cruz Sara P , Paulsson Mattias , Kammonen Katja , Rautamo Maria , Lueck Hendrik , Heindl Herwig , Carrez Laurent , Pierrot Antoine , Harnish Ralf , Stareprawo Stephanie , Tubic-Grozdanii Marija , Zibolka Stefanie , Loesch Uli , Jeske Martina , Griesser Ulrich , Hummer Karin , Thalmeier Andreas , Leitner Marianne , Bischoff Susan , Heimke-Brinck Ralph , Paulus-Rohmer Janine , Khouckh Karim , Bruno Fabien , Harjans Anna , Hoppe-Tichy Torsten
Published: March 2024

Pharmacy compounding, the art and science of preparing customized medications to meet individual patient needs, is in a verge of transformation. Traditional methods of compounding often involve manual and time-consuming processes, presenting challenges in terms of consistency, dosage accuracy, quality control, contamination and scalability. However, the emergence of cutting-edge technologies has paved a way for a new era for pharmacy compounding, promising to redefine the way medications are prepared and delivered as pharmacy-tailored personalized medicines. In this multi-site study, more than 30 hospitals and community pharmacies from 8 countries in Europe utilized a novel automated dosing approach inspired by 3D printing for compounding of non-sterile propranolol hydrochloride tablets. CuraBlend® excipient base, a GMP manufactured pharma-ink, intended for automated compounding applications was used. A standardized study protocol to test the automated dosing of tablets with variable weights was performed in all participating pharmacies in 4 different iterative phases. Integrated quality control was performed with an in-process scale and NIR spectroscopy supported by HPLC content uniformity measurements. In total, 6088 propranolol tablets were produced at different locations during this study. It was shown that the dosing accuracy of the process increased from about 90% to 100% from phase 1 to phase 4 by making improvements to the formulation and the hardware solutions. The results indicate that through this novel automated and quality-controlled compounding approach extemporaneous pharmacy manufacturing can take a giant leap forward towards automation and digital manufacture of dosage forms in hospital pharmacies and compounding pharmacies.
The Talent Management Digitalization and the Company Size as a Catalyst
Authors: Martínez-Morán Pedro César , Díez Fernando , Solabarrieta Josu , Fernández-Rico Urgoiti José María , Igoa-Iraola Elene
Published: March 2024

As companies increasingly undergo digital transformation, the role of talent management pro-cesses becomes pivotal in enhancing overall organizational performance. The research addresses the significance of talent management in corporate digital transformation, examining whether variations in the digitalization of these processes can be attributed to company size. A qualitative approach was employed, utilizing a questionnaire, collecting responses from 202 organizations across diverse sectors. Findings reveal disparities in digitalization throughout the talent man-agement process, with pronounced presence in the attracting, selecting, and rewarding phases, but diminishing in deployment and development, further declining in planning. A positive cor-relation between company size and adoption of specific digital platforms was observed. Larger enterprises exhibit greater utilization of digital platforms in talent deployment and development. Moreover, corporate communication tools are consistently utilized in the rewarding phase, irre-spective of company size. These findings offer practical insights for organizations to optimize their digitalization strategies based on their scale, thereby contributing to more effective and tailored digitalization endeavors. The uniqueness of this research lies in its exploration of the in-fluence of company size on the digitalization of talent management processes and its potential to explain variations across different stages of these processes.
Development and Comprehensive Characterization of Magnetic Chitosan Particles for Clean Removal of Pollutants from Water
Authors: Murcia-Salvador Ainoa , Rodríguez-López María Isabel , Pellicer José Antonio , Gómez-Morte Teresa , Auñón-Calles David , Yáñez-Gascón María Josefa , Cerón-Carrasco José P. , Núñez-Delicado Estrella , Gabaldón José Antonio
Published: March 2024

A single water pollution by dyes is a huge environmental problem; there is a necessity to produce new decolorization methods that are effective, cost-attractive, and suitable in industrial use. Magnetic chitosan polymers offer the advantage of easy separation from the dye solution. In this work, a Chitosan-Fe polymer was synthesized, characterized, and tested for removal of the azo dye Direct Red 83:1 from water. The polymer was characterized in terms of surface morphology (SEM), elemental analysis (EA), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), infrared spectrophotometry (IR), X-ray powder diffraction (XRD) and density functional theory (DFT). The reported results hint that 1 g and pH 7.0 were the best conditions to carry out both kinetic and isotherm models. To understand the adsorption behavior of Direct Red 83:1 onto the polymers, adsorption rate and maximum adsorption capacity were calculated using kinetic tests and isotherm curves respectively. The kinetic data and mechanism of the adsorption process were analyzed by three models and the equilibrium data by three adsorption isotherms. The results indicated that the adsorption process follows a pseudo-second-order kinetics (R2= 0.999) and fits the Temkin isotherm (R2= 0.946), indicating that the adsorption occurred on heterogeneous surfaces. The newly synthesized Chitosan-Fe polymer exhibited good adsorption properties and easy separation of cleaned water.
High Prevalence of Hepatitis B Virus Drug Resistance Mutations to Lamivudine Among People with HIV/HBV Coinfection in Rural and Peri-Urban Communities in Botswana
Authors: Phinius Bonolo B. , Anderson Motswedi , Gobe Irene , Mokomane Margaret , Choga Wonderful T. , Mokomane Margaret , Choga Wonderful T. , Mpebe Gorata , Makhema Joseph , Shapiro Roger , Lockman Shahin , Musonda Rosemary , Moyo Sikhulile , Gaseitsiwe Simani
Published: March 2024

(1) Background: We aimed to determine the prevalence of hepatitis B virus (HBV) resistance-associated mutations (RAMs) in people with HBV and human immunodeficiency virus (HBV/HIV) in Botswana. (2) Methods: We sequenced HBV from participants with HBV/HIV from the Botswana Combination Prevention Project study (2013-2018) using the Oxford Nanopore GridION platform. Consensus sequences were analyzed for genotypic and mutational profiles. (3) Results: Overall, 98 HBV sequences had evaluable reverse transcriptase region coverage. The median participant age was 43 years (IQR: 37, 49) and 66/98 (67.4%) were female. Most participants, 85/97 (87.6%) had suppressed HIV viral load (VL). HBV RAMs were identified in 61/98 (62.2%) participants. Most RAMs were in positions 204 (60.3%), 180 (50.5%) and 173 (33.3%), mostly associated with lamivudine resistance. The triple mutations, rtM204V/L180M/V173L and was the most predominant (17/61 [27.9%]). Most participants (96.7%) with RAMs were on antiretroviral therapy for a median duration of 7.5 years (IQR: 4.8, 10.5). Approximately 27.9% (17/61) of participants with RAMs had undetectable HBV VL, 50.8% (31/61) had VL <2000IU/mL and 13/61 (21.3%) had VL ≥2000 IU/mL. (4) Conclusions: The high prevalence of lamivudine RAMs discourages the use of ART regimens with 3TC as the only HBV-active drug in people with HIV/HBV.