bluuebunny/crossref_metadata_2025 huggingface dataset:
An Evaluation of Surface Wind and Gust Forecasts from the High-Resolution Rapid Refresh Model
Authors: Fovell Robert G. , Gallagher Alex
Published: April 2022

We utilized high temporal resolution, near-surface observations of sustained winds and gusts from two networks, the primarily airport-based Automated Surface Observing System (ASOS) and the New York State Mesonet (NYSM), to evaluate forecasts from the operational High-Resolution Rapid Refresh (HRRR) model, versions 3 and 4. Consistent with past studies, we showed the model has a high degree of skill in reproducing the diurnal variation of network-averaged wind speed of ASOS stations, but also revealed several areas where improvements could be made. Forecasts were found to be underdispersive, deficient in both temporal and spatial variability, with significant errors occurring during local nighttime hours in all regions and in forested environments for all hours of the day. This explained why the model overpredicted the network-averaged wind in the NYSM because much of that network’s stations are in forested areas. A simple gust parameterization was shown not only to have skill in predicting gusts in both networks but also to mitigate systemic biases found in the sustained wind forecasts.

Significance Statement

Many users depend on forecasts from operational models and need to know their strengths, weaknesses, and limitations. We examined generally high-quality near-surface observations of sustained winds and gusts from the nationwide Automated Surface Observing System (ASOS) and the New York State Mesonet (NYSM) and used them to evaluate forecasts from the previous (version 3) and current (version 4) operational High-Resolution Rapid Refresh (HRRR) model for a selected month. Evidence indicated that the wind forecasts are excellent yet imperfect and areas for further improvement remain. In particular, we showed there is a high degree of skill in representing the diurnal variation of sustained wind at ASOS stations but insufficient spatial and temporal forecast variability and overprediction at night everywhere, in forested areas at all times of day, and at NYSM sites in particular, which are more likely to be sited in the forest. Gusts are subgrid even at the fine grid spacing of the HRRR (3 km) and thus must be parameterized. Our simple gust algorithm corrected for some of these systemic biases, resulting in very good predictions of the maximum hourly gust.
Ethical Bonds Transformation in Bereaved Taiwanese Families: A Preliminary Study
Authors: Lee Wan-Lin , Yu Hsiu-Ting , Lin Yaw-Sheng
Published: April 2022

Ethical bonds transformation is a cultural phenomenon in Taiwanese bereaved families. When the death event occurs, the absent status of the deceased invokes spontaneous change in whole family to cope with the irreparable loss. In the present study, 283 bereaved individuals were recruited to develop the ethical bonds transformation scale. Exploratory factor analysis has generated two factors: ethical bonds and symbolic bonds. Partial correlation has shown that ethical bonds was positively correlated with post-grief growth and negatively correlated with most of the grief related symptoms, indicating that ethical bonds might be a protective factor in the family grief process.
The Apple Doesn’t “Feel” Far From the Tree: Mother–Child Socialization of Intergroup Empathy
Authors: Ran Shira , Reifen Tagar Michal , Tamir Maya , Halperin Eran
Published: April 2022

Like adults, children experience less empathy toward some groups compared with others. In this investigation, we propose that mothers differ in how much empathy they want their children to feel toward specific outgroups, depending on their political ideology. We suggest that how mothers want their children to feel (i.e., the motivation for their child’s empathy), in turn, is correlated with children’s actual experience of empathy toward the outgroup. Across four studies in the context of the Israeli-Palestinian conflict ( NTotal = 734), the degree of empathy mothers wanted their children to experience in the intergroup context varied as a function of their political ideology. Mothers’ motivation for their child’s empathy toward the outgroup (but not in general) was further associated with how they chose to communicate messages to their children in a real-life context and how children actually felt toward the outgroup. We discuss implications for the socialization of intergroup empathy.
SceneFND: Multimodal fake news detection by modelling scene context information
Authors: Zhang Guobiao , Giachanou Anastasia , Rosso Paolo
Published: April 2022

Fake news is a threat for the society and can create a lot of confusion to people regarding what is true and what not. Fake news usually contain manipulated content, such as text or images that attract the interest of the readers with the aim to convince them on their truthfulness. In this article, we propose SceneFND (Scene Fake News Detection), a system that combines textual, contextual scene and visual representation to address the problem of multimodal fake news detection. The textual representation is based on word embeddings that are passed into a bidirectional long short-term memory network. Both the contextual scene and the visual representations are based on the images contained in the news post. The place, weather and season scenes are extracted from the image. Our statistical analysis on the scenes showed that there are statistically significant differences regarding their frequency in fake and real news. In addition, our experimental results on two real world datasets show that the integration of the contextual scenes is effective for fake news detection. In particular, SceneFND improved the performance of the textual baseline by 3.48% in PolitiFact and by 3.32% in GossipCop datasets. Finally, we show the suitability of the scene information for the task and present some examples to explain its effectiveness in capturing the relevance between images and text.
Dynamic associations between stress and relationship functioning in the wake of COVID-19: Longitudinal data from the German family panel (pairfam)
Authors: Pauly Theresa , Lüscher Janina , Berli Corina , Scholz Urte
Published: April 2022

Individuals all across the world experienced significant disruptions in their personal and family life with the outbreak of the new coronavirus disease 2019 (COVID-19). The current study investigated dynamic associations between stress and relationship functioning over time in the face of the COVID-19 pandemic. Perceived stress, relationship satisfaction, and relationship quality (appreciation, intimacy, conflict) were reported by 1483 young to middle-aged participants who were in a romantic relationship and lived with their partner in 2018/2019 and in May–July 2020 (a few months after the onset of COVID-19). Data were analyzed using bivariate latent change score models. Relationship functioning (satisfaction, appreciation, intimacy) showed small decreases from before to during the pandemic. Contrary to expectations, levels of perceived stress also decreased on average from before to during the pandemic. Changes in relationship functioning were correlated with changes in stress over time, so that participants with greater decreases in relationship satisfaction, appreciation, and intimacy and greater increases in conflict from before to during the pandemic showed lesser decreases/greater increases in stress. Higher pre-pandemic relationship satisfaction was associated with greater decreases/lesser increases in stress from before to during the pandemic. Pre-pandemic levels of other measures of relationship functioning or stress were not associated with changes in outcomes over time. Results add to the literature demonstrating that stress is closely intertwined with the functioning of intimate relationships. Furthermore, they suggest that greater relationship satisfaction may serve as a protective factor for stressful life events.
Magnetic concentric tube robots: Introduction and analysis
Authors: Peyron Quentin , Boehler Quentin , Rougeot Patrick , Roux Pierre , Nelson Bradley J , Andreff Nicolas , Rabenorosoa Kanty , Renaud Pierre
Published: April 2022

In this paper, we propose a new type of continuum robot, referred to as a magnetic concentric tube robot (M-CTR), for performing minimally invasive surgery in narrow and difficult-to-access areas. The robot combines concentric tubes and magnetic actuation to benefit from the ‘follow the leader’ behaviour, the dexterity and stability of existing robots, while targeting millimetre-sized external diameters. These three kinematic properties are assessed through numerical and experimental studies performed on a prototype of a M-CTR. They are performed with general forward and inverse kineto-static models of the robot, continuation and bifurcation analysis, and a specific experimental setup. The prototype presents unique capabilities in terms of deployment and active stability management, while its dexterity in terms of tip orientability is also among the best reported for other robots at its scale.
Release of Interleukin-1β evaluation among mineral oil mist‐exposed workers
Authors: Gandomani Elham A , Mosaffa Nariman , Zendehdel Rezvan , Kohneshahri Mehrdad H , Vahabi Masoomeh , Sabour Siamak
Published: April 2022

Exposure to aerosols has been found to be linked to respiratory impairment. Although the effects of both indoor and outdoor exposures to particulates have been extensively reported, exposures to mists are less studied. Herein, we reported a survey of mineral oil mist toxicity in an occupational exposure scenario. For the purpose of this study, 65 lathe workers of the metal processing industry, as mineral oil mist–exposed population, were studied. Thereafter, the participants’ age, smoking habits and work experience were matched with those of the control workers ( n = 65) who were not occupationally exposed to mist. Thereafter, air samples were evaluated from the breathing zone of the workers using NIOSH method 5026. Plasma Interleukin-1β as a pro-inflammatory indicator was assessed in all the studied subjects. Mean ± standard deviation of mineral oil mist time-weighted average exposure in lathe workers was 7.10± 3.49 mg/m3. IL-1β cytokine levels were significantly higher in the lathe groups compared to the control group. The mean level of Interleukin-1β in the control subjects (2922 pg/L) was selected as the cut-off point of the inflammation effect. Based on this pro-inflammatory point, the results of monitoring showed that 60% of the exposed were affected. A Spearman correlation was also found between mineral oil mist exposure and inflammation in the affected subjects. Our findings highlighted the immunological potential of mineral oil mist in occupational exposure. Overall, the results of this study suggested that Interleukin-1β evaluation in mineral oil mist exposure could be considered as both an acute and chronic inflammation marker.
Risk Factors for Experiencing Gender Based Violence Across Racial Groups
Authors: Baldwin-White Adrienne , Daigle Leah , Teasdale Brent
Published: April 2022

Background

College student interpersonal violence victimization is a major public health issue. Sexual assault and intimate partner violence have negative effects on mental and physical health, as well as an individual’s ability to perform well academically and fully participate in the college experience. Because an individual’s race impacts how they experience the world, it is important to consider racial differences in experiences of interpersonal violence.

Study Question

This study sought to understand the particular characteristics of Black, White, and Hispanic students that increase their risk of experiencing interpersonal violence victimization.

Method and Subjects

Researchers performed a latent class analysis using the Spring 2013 data from the American College Health Association’s National College Health Assessment II to determine whether the risk factors for victimization of college students vary based on race. Data was collected from 123,078 college students attending 153 institutions of higher learning.

Findings

Results of this latent class analysis showed a 5 class solution where each class had unique risks that increased the potential for interpersonal violence victimization based on the race of the respondent.

Implications

Group based differences need to be considered when developing prevention strategies to reduce the risk of victimization on college campuses. Because different risks increase victimization for White, Black, and Hispanic students, it is important to consider how risk reduction strategies may differ for these groups; and ensure that all prevention strategies are culturally informed.
The Effect of Domestic Violence During Pregnancy on Cortisol Hormone Release, Breastfeeding, and Newborn
Authors: Avcı Sezer , Ortabag Tulay , Ulusal Hasan , Taysi Seyithan
Published: April 2022

This study was conducted to determine the effect of domestic violence during pregnancy on the cortisol hormone release, preterm birth, low birth weight, and breastfeeding status. The cross-sectional study was conducted with 255 pregnant women in a Family Health Centre in the Southeastern Anatolia Region of Turkey between October 2017 and August 2018. The questionnaire, DVWDS (Domestic Violence to Women Determination Scale) and Breastfeeding Self-Efficacy Scale were used to collect the data. In the present study, the pregnant women were followed up three times. The first follow-up was applied to the pregnant women in the second trimester, the second follow-up was applied to those in the third trimester, and the third follow-up was applied to the postpartum women. At each follow-up from newborn, cortisol hormone level was taken with saliva and evaluated. It was determined that 9.8% of the pregnant women participating in the study were exposed to violence by their partners. An important result was found that those who were exposed to domestic violence during their pregnancy gave birth in the 37th week ( p < 0.05). It was seen that the babies of those exposed to domestic violence during pregnancy had a higher mean cortisol hormone level ( p < 0.05). It was found that the mean score of the Breastfeeding Self-Efficacy Scale in the third follow-up was lower for those who were exposed to domestic violence during pregnancy than those who were not ( p < 0.05). It was observed during the pregnancy that domestic violence affected cortisol hormone secretion, breastfeeding after birth and newborn health.
Street Art Commodification and (An)aesthetic Policies on the Outskirts of Lisbon
Authors: Raposo Otávio Ribeiro
Published: April 2022

In this article, I discuss how street art has become an ally of urban policies molded by the creative city paradigm in marginalized neighborhoods of Lisbon (Portugal). Based on a dense ethnography of a peripheral neighborhood of this Southern European city, I follow the trail left by how public power uses the commodification of street art as an instrument for urban regeneration, touristification, and management of inequalities. The different meanings and interests around this policy are examined in street art festivals and tours, focused on the participation of young people as local guides. This urban policy has changed the negative public image of the neighborhood, with street art being combined with a multicultural experience commodified in guided tours for tourists. However, by ignoring the opinions of the residents on the interventions, this policy follows a top-down approach in which street art aesthetics operate as a device of subjugation and maintenance of the subaltern, beautifying processes of exclusion.
Role of formulation additives on the properties of thermoplastic polyether ester elastomer-based and carbon fabric-reinforced multilayer composites
Authors: Yasar Miray , Celebi Hande , Bayram Goknur
Published: April 2022

In this study, multilayer carbon fabric-reinforced composites (CFRC) were manufactured by compression molding technique with the combination of carbon fabric and thermoplastic polyether ester elastomer (TPEE) composites. The TPEE-based polymer layers were prepared as binary, ternary, and quaternary composites using carbon black (CB) or N-(β-aminoethyl)-γ-aminopropyl-trimethoxysilane (AEAP) modified carbon black (mCB), ethylene-glycidyl methacrylate copolymer (EGMA) and/or paraffin oil. The effects of formulation additives on multilayer CFRC were investigated in terms of their mechanical, electrical resistivity, electrically stimulated shape memory properties and morphologies. Tensile modulus of neat TPEE included multilayer CFRC increased slightly with the addition of both mCB and oil to TPEE. The highest impact strength of 112.2 kJ/m2 was obtained for TPEE-mCB-EGMA-Oil containing CFRC multilayer composites, which was 30% higher than CFRC with neat TPEE. All modified and reinforced CFRC exhibited higher electrical conductivities than neat TPEE containing CFRC. Electrically triggered bending test showed that combination of TPEE, mCB, EGMA and oil together with carbon fabric in multilayer structure revealed 80% shape recovery ratio within less than 2 min.
Study on selective laser sintering process and investment casting of rice husk/ Co-Polyamide (Co-PA hotmelt adhesive) composite
Authors: Li Haolin , Guo Yanling , Shuhui Tong , Jian Li , Idriss Aboubaker IB
Published: April 2022

The current available wood-plastic materials used for selective laser sintering (SLS) investment casting are often poor in fluidity in molten state, which is not easy to flow out the shell mold. This led to a large amount of residual ash in mold after heating and lowered the quality of the sintered parts. In this article, the Co-Polyamide (Co-PA Hotmelt adhesive) and rice husk powders (RH) were proposed as the feedstock of the rice husk (RH)/CO-PA composite (RHPA) for SLS. CO-PA with good fluidity was used as the matrix and RH powder as the additive materials. This paper aims to optimize the SLS processing parameters and determine the optimal ratio of RHPA parts manufactured by SLS. Through this work, an orthogonal experimental method of five factors and four levels was used to determine the optimum SLS parameters for the RHPA SLS test. The scan spacing, scan speed, laser power, layer thickness, and preheating temperature are chosen as main SLS affecting factors of this study. The synthesis weighted scoring methods were used to conclude the optimal combination of SLS parameters of RHPA i.e., scan spacing = 0.15mm, scan speed = 2m/s, laser power =16W, layer thickness = 0.25 mm and the preheating temperature = 74°C. Moreover, the influence of RH content on the mechanical properties, dimensional accuracy, and the residual ash content of RHPA parts was determined. When the ratio of RH powder on RHPA is 10 wt %, the bending strength of the sintered parts will reach 2 MPa. Besides, the residual ash content of RHPA parts after heating step was lower (1.1881%) and the tolerance level is CT5. Thus, the dimensional accuracy in X, Y, and Z directions of 10 wt % RHPA SLS parts is 99.79%, 98.71%, and 97.9%, respectively; and the surface of casting was smooth and clear details.
Effect of Flax/PP pellets’ morphology on the mechanical properties of injection-molded parts
Authors: Alsinani Nawaf , Laberge Lebel Louis
Published: April 2022

Flax and polypropylene (PP) pultrudates of 4.76 mm in diameter were produced using a multi-die pultrusion system. The flax content was 50 vol.%. Pultrusion conditions were varied to produce four porosity content between 4% and 22%. The pultrudates were pelletized into lengths of 6 and 15 mm, and injection-molded with pure PP to reduce the part flax content to 25 wt.%. Results showed that well consolidated pultrudates, having porosities up to 8%, were more resilient to the pelletizing process such that the pellets remained structurally intact after the process. These pellets went smoothly through the hopper into the injection molding machine screw. Pellets with void content higher than 8% lost integrity during pelletizing leading to uniform mixing. Exposed fibers segregated from the polymer in the hopper leading to ununiform mixing. The highest mechanical properties improvement compared to pure PP was using 15 mm pellets that had a prorosity of 8%. The tensile modulus doubled at 4652 ± 113 MPa. The impact strength increased by almost five times at 10.5 ± 0.7  [Formula: see text]. 15 mm pellets provided 1.7 times the impact strength of the 6 mm pellets. These improvement are attributed to low flax fiber thermal degradation and improved fiber dispersion.
The influence of expandable graphite on the thermal, flame retardant and mechanical characteristics of short carbon fiber reinforced polyamide composites
Authors: Has Musa , Erdem Aysegul , Savas Lemiye Atabek , Tayfun Umit , Dogan Mehmet
Published: April 2022

The fire retardant performance of carbon fiber (CF) reinforced polyamide 6 (PA 6) composites plays an important role in their novel application fields. Thus, expandable graphite (EG) is integrated into CF containing PA 6 composite system to donate halogen-free flame retardant property based upon intumescence. The effect of EG amount on the thermal, flame retardant, and mechanical properties of CF reinforced PA 6 composites is examined. The properties of the composites are investigated using thermogravimetric analysis (TGA), limiting oxygen index (LOI), vertical burning test (UL-94 V), mass loss calorimeter (MLC), tensile, and impact tests. According to the test results, thermal stability reduces as the added amount of EG increases. The addition of EG improves fire performance and reduces the flammability characteristics of CF containing PA6 composites. The highest LOI value (36.4%), UL-94 V rating (V0), and the lowest peak heat release rate (pHRR) (74 kW/m2), total heat evolved (THE) (23.9 MJ/m2) values are observed with the inclusion of 30 wt% EG. The impact strength increases at 10 wt% EG addition, whereas negligible change is observed at higher EG loadings with respect to the reference sample. The increase in tensile modulus and the reductions in tensile strength and percentage elongation are observed as the added amount of EG increases. In brief, CF reinforced PA6 composites gain multifunctional characteristic with the help of interaction between EG and CF based on condensed phase fire-proofing behavior.
The Role of Country-Level Availability and Generosity of Healthcare Services, and Old-Age Ageism for Missed Healthcare during the COVID-19 Pandemic Control Measures in Europe
Authors: Settels Jason , Leist Anja K.
Published: April 2022

Objectives: The effects of the COVID-19 outbreak on non-COVID-19-related healthcare need further investigation. Methods: Using the Survey of Health, Ageing and Retirement in Europe’s COVID-19 module (2020) ( N = 57,025), country-level data from the European Social Survey (2008) and OECD (2020), and logistic regressions, this study examines predictors of older Europeans’ forgone, postponed, and denied healthcare during the pandemic. Results: Country-level availability of physicians, healthcare systems’ generosity, and beliefs that older persons burden healthcare systems all increased forgone healthcare. Healthcare system generosity increased postponed and denied healthcare. Greater medical resources decreased denied healthcare. Furthermore, missed healthcare varied by individual-level gender (higher rates among women), age, education, and health. Discussion: This study reveals predictors of missed healthcare during the pandemic. To decrease unintended health consequences of a pandemic, both individual-level determinants, such as gender and health, and contextual-level determinants, such as healthcare systems’ characteristics, should be considered in research and practice.
Hook plate fixation with versus without coracoclavicular reconstruction for distal clavicular fractures
Authors: Wu Shuang , Chen Jialei , Zhang Jie , Shakya Sujan , Xing Fei , Sun Jiachen , Xiang Zhou
Published: April 2022

Purpose

Hook plate fixation is one of the most frequently used methods for unstable distal clavicular fractures, but it is still unknown if there is a need for coracoclavicular (CC) reconstruction. This study aimed to compare the efficacy of hook plate fixation with versus without CC reconstruction for distal clavicular fractures.

Methods

Eighty-one patients who underwent hook plate fixation (HP group, n = 45) or hook plate fixation plus suture anchor reconstruction (HPA group, n = 36) for Neer type II or V clavicular fractures were enrolled. Demographics, fracture characteristics, and surgical data were recorded. Union time, coracoclavicular distance (CCD), post-operative complications, Constant score, and Disabilities of the Arm, Shoulder, and Hand (DASH) score were compared between HPA and HP groups.

Results

Constant score in the HPA group was higher than that in the HP group (91.8 ± 3.6 vs 88.8 ± 6.0, P = 0.007). However, there were no significant differences in union time, DASH score, CCD, and post-operative complications between the two groups (P > 0.05). Hook plate fixation combined with CC reconstruction costed more (3023.7 ± 202.6 vs 2416.2 ± 167.6 EUR, P < 0.001) and prolonged operative duration (78.2 ± 9.2 vs 73.7 ± 8.3 min, P = 0.023) compared with hook plate fixation alone.

Conclusion

Hook plate fixation with or without suture anchor reconstruction achieved satisfactory outcomes for Neer type II or V clavicular fractures. However, hook plate fixation plus CC reconstruction showed better functional outcomes compared with hook plate fixation alone.
Anterior cruciate ligament reconstruction with lateral extra-articular tenodesis reduces knee rotation laxity and graft failure rate: A systematic review and meta-analysis
Authors: Feng Jing , Cao Yangbo , Tan Lingjie , Liang Jiehui , He Chunrong , He Jinshen , Wu Song
Published: April 2022

Purpose

To determine whether the addition of lateral extra-articular tenodesis (LET) to anterior cruciate ligament reconstruction (ACLR) reduces rotational laxity of the knee, and to compare the clinical results of this treatment with those of ACLR alone.

Methods

PubMed, Embase, and Cochrane Library were searched by two researchers for clinical studies comparing ACLR with and without LET. Studies with only evidence levels I and II and studies in which anterior lateral ligament reconstruction was performed with grafts were excluded. The risk of bias of the studies was assessed using the Cochrane risk-of-bias and modified Downs & Black tools. The outcomes included (1) functional outcomes; (2) knee laxity measures; (3) knee injury osteoarthritis and outcome score; and (4) complications. The outcomes of the two groups were extracted, summarized and compared.

Results

A total of 234 studies were retrieved and 223 were excluded. Eleven clinical studies with 1745 patients were included in our meta-analysis. Compared to the patients who underwent ACLR alone, the patients who underwent ACLR with LET had reduced pivot-shift (odds ratio [OR] 0.48, 95% confidence interval [CI] 0.31 to 0.74, p = 0.0009), and lower graft failure rate (OR 0.34, 95% CI 0.20 to 0.55, p < 0.0001).

Conclusion

Compared with ACLR only, ACLR combined with LET can effectively reduce rotation laxity of the knee joint, and reduce the graft failure rate in high-risk patients. However, the effects on the function and activity level of patients cannot be confirmed.
High-speed elevator car system semi-active horizontal vibration reduction method based on the improved particle swarm algorithm
Authors: Wang Zili , Qiu Lemiao , Zhang Shuyou , Su Guannan , Zhu Linhao , Zhang Xuewei
Published: April 2022

As the field of modern high-rise buildings advances, the demand for the high-speed elevator increases. The high-speed elevator car vibration directly affects the riding comforts, among which the high-speed elevator car horizontal vibration has the most pronounced effect. Previous researches indicate that the semi-active vibration reduction method is an effective horizontal vibration reduction method for elevator car, which has the characteristics of low energy consumption, suitable for high-speed elevator, while its adaptability is relatively weak. To address the adaptability issue, we proposed a semi-active high-speed elevator car horizontal vibration reduction method based on the improved particle swarm algorithm. To verify the feasibility of the proposed method, it is applied with a magneto-rheological damper in the KLK2-type elevator from Canny Elevator Co, Ltd The horizontal vibration results are compared with ones of the passive vibration reduction method and other algorithm-based vibration reduction methods. The vibration reduction method proposed in this paper is superior to all other mentioned methods in terms of the peak-to-peak value and the A95 value of the vibration acceleration. The horizontal vibration acceleration performance of the HSEC is improved by about 70%.
Modular Service Design of Information Technology-Enabled Services
Authors: Tuunanen Tuure , Salo Markus , Li Feng
Published: April 2022

The literature has proposed ways to modularize information-technology-enabled services (ITeS) with limited success. We argue that applying design principles (DPs) can address this gap and revitalize the service modularization literature. With a qualitative research study, we develop exemplar DPs and a set of prioritized DPs for ITeS. We contribute to the literature by demonstrating how complex service systems, specifically ITeS, can be modularly designed. Our DPs show how different ITeS design elements or service attribute combinations impact the outcome-driven design of service experience. Based on the findings, we present a modular service design framework and a service design method that adopts DPs to create effective modular ITeS designs. We also offer ways to conceptualize and apply service modularization to improve the adoption of the modular service design by service designers and managers.
Assessment of the Potential for the Formation of a Circular Phosphorus Cycle Using Substance Flow Analysis Based on Reports from Malaysia
Authors: Abdul Ghani Latifah
Published: April 2022

Sustainability of phosphorus (P) requires detailed and serious key management strategies to control the P flow balance across the environmental systems. During the 1970s, the reserve of phosphate in Malaysia was at its highest level, which led to a decline in resources to the continuous demand increased the import trading of these resources from foreign countries. Consequently, the increased import rate led to imbalanced essential nutrient flow that could impact the national security. The depletion of P reserves initiated in the 1970s triggered the Malaysian government to act quickly by comparing the performance of P accounting indicators according to its primary flow in different ministries. However, the capital injections to Small Medium Industry (SMI) and non-SMI players that increased since the mid-2000s returned the imbalanced P loss to normal. This study utilised extant literature for the development of guidelines in identifying ‘hotspots’ in P flow return, with particular emphasis on national P security achievements. Based on the findings, this study successfully documented the current research patterns of P flow in various systems related to the main P problems, evaluated flow chain requirements and possible impacts of P inputs-outputs, apart from developing solutions to guide policymakers in considering the aspects of substance flow analysis (SFA) approaches in establishing the national P modelling. To reduce the P nutrient leaching down to the levels observed in the early 1990s, a fundamental and better understanding of nutrient management practices coupled with minimised uncertainty of the P catchment scale is required. Monitoring the dispersion of P nutrient can prevent environmental degradation. In conclusion, this review provided a potential approach to achieve new management targets by proposing P load reduction strategies which focuses on the current trend of P demand-production for long-term sustainability of non-renewable resources.
The Establishment and Experimental Verification of an lncRNA-Derived CD8+ T Cell Infiltration ceRNA Network in Colorectal Cancer
Authors: Wu Qi , Zhang Zhiyuan , Ji Meiling , Yan Tao , Jiang Yudong , Chen Yijiao , Chang Jiang , Zhang Jicheng , Tang Dong , Zhu Dexiang , Wei Ye
Published: April 2022

Background:

Long noncoding RNAs (LncRNA) lead a vital role in colorectal cancer (CRC) development. The infiltrating CD8+ T cell is the main target of immunotherapy. Our study aimed to figure out the potential mechanism of lncRNAs regulating the function of CD8+ T cells in CRC.

Methods:

We collected bulk RNA-seq, miRNA-seq, and single-cell RNA-seq (scRNA-seq) data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. The cibersort algorithm and correlation analysis were used to estimate the abundance of CD8+ T cells and screened out the most relevant lncRNAs. We used scRNA-seq data to identify the main cell lncRNA expressed. Furthermore, one competing endogenous RNA (ceRNA) network focusing on the potential mechanism of lncRNA-derived CD8+ T cell infiltration was constructed. We established a co-culture system to assess the immunosuppressive function of the lncRNA. And we evaluated the effects of the lncRNA on CD8+ T cell cytotoxicity by flow cytometry, qPCR, and clone formation assay.

Results:

Three CD8+ T cell infiltration-related lncRNAs were identified, and LINC00657 was expressed mainly in tumor cells, negatively associated with CD8+ T cell infiltration. Hsa-miRNA-1224-3p and hsa-miRNA-338-5p and SCD, ETS2, UBE2H, and YY1 were identified to construct the ceRNA network. Immunosuppression-related tumor marker CD155 was proved to be positively correlated with LINC00657 and mRNAs in the ceRNA network. In addition, we proved that LINC00657 could impair the cytotoxicity of CD8+ T cells, and its expression was positively associated with CD155 in vitro.

Conclusions:

We successfully constructed an lncRNA-derived CD8+ T cell infiltration ceRNA network in CRC. LINC00657 may play a leading role in the CRC immune escape and could be a novel immunotherapy target.
Humanising gaming? The politics of posthuman agency in autobiographical videogames
Authors: Gallagher Rob
Published: April 2022

For many commentators autobiographical videogames represent a step towards a more human vision of digital play, promising to transform a medium still widely associated with mindless and dehumanising virtual violence into a vector for self-expression, empathy and understanding. Viewed through the lens of life-writing theory, however, the situation looks somewhat different. As scholars in this fieldhave shown, works of auto/biography and life-writing have been instrumental in propagating ideas about agency, politics and the human that remain both pervasive and pernicious. Their work suggests that if we are to talk about ‘humanising’ videogames we must first address how understandings of the human are constituted and who they have historically excluded. Here developments in life-writing theory align with recent scholarship on how videogames undercut the liberal humanist conception of the autonomous agential subject by implicating players in complex assemblages of human and non-human actors. This work holds out another way of reading the encounter between gaming and auto/biography: as a catalyst for new forms of posthumanist life-writing, in which the autobiographical mode co-exists with what this article dubs the ludobiographical mode. If games are autobiographical to the extent that they involve creators giving an account of episodes from their own life, they are ludobiographical to the extent that they foreground the challenges videogames pose to humanism’s vision of autonomous individuals in possession of their own bodies, stories and identities. This idea is elaborated through an analysis of That Dragon, Cancer ( Numinous Games, 2016 ). Created by Ryan and Amy Green, the game documents the death of their developmentally disabled son Joel and their consequent crisis of faith. Controversial and widely discussed, it constitutes a rich case study in how autobiographical videogames raise irreducibly political questions about agency, identity and the (post)human.
Sexual and Relationship Violence Among LGBTQ+ College Students: A Scoping Review
Authors: Klein L.B. , Dawes Hayden C. , James Greeshma , Hall William J. , Rizo Cynthia Fraga , Potter Sharyn J. , Martin Sandra L. , Macy Rebecca J.
Published: April 2022

Although there has been increased attention to campus sexual and relationship violence (SRV) because of Title IX and the #MeToo movement, much of that attention has focused on victimization of cisgender heterosexual women. This scoping review uncovers information from empirical studies on what is known about LGBTQ+ (e.g., lesbian, gay, bisexual, transgender, queer, and nonbinary) students’ experiences of campus SRV. Using rigorous scoping review methods (i.e., searches of 15 databases, searches of expert websites, hand searching, reference harvesting, and forward citation chaining), we identified 60 documents published since 2000 that contained findings from empirical studies related to LGBTQ+ students and SRV on U.S. college and university campuses. Through content analysis, we summarized findings around five key themes: (1) extent and types of victimization, (2) negative outcomes, (3) knowledge of and attitudes about SRV, (4) perspectives on SRV services and prevention education programs, and (5) recommendations from study authors based on their findings. Implications for research, practice, and policy based on these findings are discussed.
Thermo- and pH-sensitive nanoparticles of poly (N-isopropylacrylamide-decenoic acid-1-vinylimidazole) for ultrasound switchable fluorescence imaging
Authors: Saremi Bahar , Yao Tingfeng , Yuan Baohong
Published: April 2022

We herein report the synthesis of poly (9-decenoic acid-1-vinylimidazole- N-isopropylacrylamide) nanoparticles containing indocyanine green (ICG) in one pot and in water phase throughout the reaction. We have shown that copolymers of 9-decenoic acid and 1-vinylimidazole, or 9-decenoic acid alone, have an enhanced sensitivity to pH values between 7.4 and 6.8 and are superior to the widely used acrylic acid. We have also shown that incorporation of acidic comonomers leads to the favorable outcome of a higher fluorescence signal intensity in lower pH values, whereas the opposite is true of basic comonomers, where the fluorescence signal intensity is lower at low pH values. It was shown that to keep the pH response favorable the molar ratio of basic comonomers to acidic comonomers should roughly equal 1:4. We controlled the lower critical solution temperature (LCST) of the nanoparticles from around 30 to 38°C for different applications by adding acrylamide comonomers. Finally, the nanoparticles at varying pH values, when imaged by an ultrasound switchable fluorescence (USF) imaging system, showed pH sensitivity and thermosensitivity at physiological and tumor pH.
Showing How They Made Them Move: Early Making-of Documentaries on the Production of Animated Films
Authors: Hasebrink Felix
Published: April 2022

Contrary to popular belief, ‘making-of’ documentaries are not a phenomenon of contemporary home cinema culture, but have a long pre-DVD history. This article engages with a special subcategory: ‘making-of’ documentaries on the production of animation. With a focus on French and American examples, the author retraces the transition of production imagery from metaleptic cartoons to emergent documentary genres of the 1930s, arguing that this historical shift reformulated the question of how the creation of animated films can be captured cinematically. Providing decidedly nonfiction (but not necessarily ‘objective’) images of the making of animation, the films challenged established concepts to address the realm of cinematic production. The article seeks to examine this theoretical potential, using the notion of a cinematic hors-cadre as a key example.
The intervening effect of the What Being the Parent of a New Baby is Like-Revised questionnaire on maternal affect
Authors: van Beeck AH Elise , Pridham Karen F , Kuipers Yvonne
Published: April 2022

The ‘What Being the Parent of a New Baby is Like-Revised’ (WPL-R) is an instrument designed to measure adaptation to parenthood. In the process of pilot testing and validating the WPL-R in a postpartum Dutch population, we became aware of the potentially sensitive nature of the measure. Despite the ethics committee waiving the invasive nature of the measure, we conducted a survey to explore its possible effect on women’s thoughts and emotions by using the Positive And Negative Affect Schedule (PANAS) to measure changes associated with completion of the WPL-R. Two hundred and fifteen questionnaires were returned. Our findings indicated a change in PANAS scores, implying an intervening effect when using the WPL-R, in research. This raises the question of whether it is acceptable to use a questionnaire with postpartum women without any knowledge of the possible effect it may have, even though the ethics committee has approved the study and considers the measure to be non-invasive.
Long-term immunological consequences of anti-CD20 therapies on humoral responses to COVID-19 vaccines in multiple sclerosis: an observational study
Authors: Moser Tobias , O’Sullivan Ciara , Otto Ferdinand , Hitzl Wolfgang , Pilz Georg , Schwenker Kerstin , Mrazek Cornelia , Haschke-Becher Elisabeth , Trinka Eugen , Wipfler Peter , Harrer Andrea
Published: April 2022

Background:

Anti-CD20 therapies induce pronounced B-cell depletion and blunt humoral responses to vaccines. Recovery kinetics of anti-CD20 therapy-mediated cellular and humoral effects in people with multiple sclerosis (pwMS) are poorly defined.

Objective:

To investigate the duration of the anti-CD20 treatment-induced effects on humoral responses to COVID-19 vaccines.

Methods:

This retrospective observational study included pwMS who had discontinued anti-CD20 therapy for ⩾12 months and remained without immunomodulation. We retrieved demographics and laboratory parameters including B-cell counts and immunoglobulin (IgG, IgM, IgA) levels prior to anti-CD20 commencement (baseline) and longitudinally after anti-CD20 treatment discontinuation from electronic medical records. Humoral responses to SARS-CoV-2 vaccines were compared with a population of 11 pwMS with ongoing anti-CD20 medication (control cohort).

Results:

A total of 24 pwMS had discontinued anti-CD20 therapy for a median of 34 months (range: 16–38 months). Antibody responses to COVID-19 vaccines were available in 17 (71%). Most individuals ( n = 15, 88%) elicited a measurable antibody response [mean: 774 BAU/ml (±SD 1283 BAU/ml)] to SARS-CoV-2 immunization on average 22 months (range: 10–30 months) from the last anti-CD20 infusion, which was higher compared with the population with ongoing anti-CD20 therapy ( n = 11, mean: 12.36 ± SD 11.94 BAU/ml; p < 0.00001). Significantly increased antibody levels compared with the control cohort were found among pwMS who were vaccinated >18 months after treatment discontinuation (19–24 months: n = 2, p = 0.013; 25–36 months: n = 9; p < 0.001). The interindividual kinetics for B-cell reconstitution were heterogeneous and mean B-cell counts approached normal ranges 18 months after treatment discontinuation. There was no correlation of B-cell repopulation and vaccine responses. Mean total IgG, IgM, and IgA levels remained within the reference range.

Conclusion:

Anti-CD20-induced inhibition of humoral responses to COVID-19 vaccines is transient and antibody production was more pronounced >18 months after anti-CD20 treatment discontinuation. The immunological effect on B-cell counts appears to wane by the same time.
Appearance and Performance Enhancing Drugs and Substances: The Role of the School Nurse
Authors: Siegmund Lee Anne
Published: April 2022

The purpose of this article is to provide the school nurse with the ability to recognize performance and appearance enhancing substance use and understand treatment and prevention strategies to reduce associated health risks. The use of appearance and performance enhancing drugs and substances, also known as “doping,” has been an ethical and health issue in sports for many years. It is vital that school nurses learn to recognize performance and appearance enhancing substance use to ensure student athletes and exercisers receive the care and education they need. Commonly used performance and appearance enhancing substances include anabolic-androgenic steroids, stimulants, diuretics, growth hormone, and supplements. Signs and symptoms that may look similar to other health concerns include palpitations, stunted growth, acne, severe headaches, muscle cramps, dizziness, and dehydration, but some long-term severe complications occur as well. Doping can lead to severe and sometimes permanent organ damage, including liver, kidney, and heart disease. The school nurse can play a key role by working with parents, coaches, school counselors, and educators to foster an anti-doping culture.
Will psilocybin lose its magic in the clinical setting?
Authors: Hayes Caroline , Wahba Mourad , Watson Stuart
Published: April 2022

Psilocybin as a novel treatment for depression is garnering a lot of attention from both the mainstream media and the academic community. Although phase 3 trials are only just beginning, we feel that it is important for clinicians to consider what psilocybin-assisted psychotherapy might look like in the clinical setting. In this narrative review article we have considered the difficulties that may arise as psilocybin emerges from the research setting, which may hamper its progress towards becoming a licenced medication. Psilocybin has its own unique challenges: the expectation patients come to dosing with having read overwhelmingly positive media; patient suggestibility under the influence of psilocybin and requirement for specialised therapists to name a few. We have also made some recommendations for measures that should be taken in both the phase 3 trials and with clinicians to try and minimise some of the issues raised. In doing so our hope is that psilocybin will continue towards becoming a licenced medication that suitable patients are able to access with relative ease. Practicing psychiatrists need to have an awareness of the potential pitfalls of psilocybin as they will be responsible for prescribing it in the future.
Incidence of dural metastases in castrate-resistant prostate cancer
Authors: Khondker Adree , Kwong Jethro CC , Tran Christopher , Evans Emily , Aditya Ishan , Raveendran Lucshman , Chen Yingming A , Ali Amna , Feifer Andrew
Published: April 2022

Purpose:

The natural history and clinical manifestations of dural metastases (DM) in castrate-resistant prostate cancer (CRPC) will change with advances in new hormonal therapy. Here, we characterised the incidence, clinical presentation, and outcomes of patients with DM in a contemporary patient cohort with CRPC.

Methods:

We retrospectively reviewed our CRPC database from 2012 to 2020. The primary outcome was the diagnosis of DM, defined as metastasis to the dura mater in the brain or spine. We describe the presenting symptoms, biochemistry, radiologic findings, and therapy sequence for all DM patients. Multivariable logistic regression was performed to identify predictors of DM.

Results:

Six of the 275 patients (2.2%) with CRPC developed DM. The average age of CRPC diagnosis for patients with DM was 65.6 years. Mean patient survival was 4.5 months after the diagnosis of DM. At the time of CRPC diagnosis, patients who developed DM were significantly younger, had lower baseline haemoglobin, higher lactate dehydrogenase (LDH), and elevated alkaline phosphatase (ALP) compared to those without DM. On multivariable analysis, younger age of CRPC diagnosis was found to be a predictor for DM.

Conclusion:

The presence of neurological symptoms in the context of younger age, anaemia, and elevated baseline LDH and ALP are associated with DM in CRPC.

Level of Evidence:

4