bluuebunny/crossref_metadata_2025 huggingface dataset:
Post-chemotherapy maintenance treatment by nicotinamide riboside, a poly ADP ribose polymerase 1 inhibitor, in BRCA mutated advanced ovarian cancer – A perspective
Authors: Gharote Mukul Arvind , Deshpande Amruta Ashok
Published: August 2021

Poly ADP ribose polymerase 1 (PARP-1) inhibitors are approved for post-chemotherapy maintenance in BRCA mutated ovarian carcinoma. Various PARP-1 inhibitors such as olaparib, rucaparib, niraparib, and veliparib are approved for this indication. These PARP-1 inhibitors are costly as well as having toxic potential, anemia, and neutropenia is the major side effects. Most of the middle-aged women in Indian subcontinent are anemic and prescription of PARP-1 inhibitors is tricky in such conditions, besides their cost is at times unaffordable as maintenance chemotherapy. Hence, we need an affordable yet lesser toxic PARP-1 inhibitor to solve this problem. Nicotinamide, a vitamin B3 amide can be re-purposed as PARP-1 inhibitor. Nicotinamide, albeit at a higher dose, can be efficacious as well as economical in its use as maintenance chemotherapy. It has toxic potential but the toxicity is both rare and manageable. We need a clinical trial for this purpose. Following perspective is on the current evidence on high dose nicotinamide and it is re-purposing as PARP-1 inhibitor.
Apelin
Authors: Пальцын А.А. , Свиридкина Н.Б.
Published: August 2021

Апелин - слово, появившееся в 1998 году. Так, по аббревиатуре рецептора APJ, авторы назвали, найденный ими лиганд этого рецептора. Существует в нескольких изоформах, от 13 до 77 аминокислотных остатков. Наиболее активна самая короткая форма: апелин-13. Образуется жировой и мышечной тканью - адипокин и миокин. В экспериментах на мышах обнаружено много положительных эффектов действия апелина, в том числе торможение развития старости. В нарастающем потоке клинических результатов есть сообщения о благоприятном действии апелина при нарушениях энергетического обмена, сердечно-сосудистой патологии, гипоксических состояниях, саркопении, ожирении, диабете.

Apelin is a word that emerged in 1998. This is how the authors named the APJ receptor ligand they discovered, by the abbreviation of this receptor. Apelin exists in several isoforms ranging in size from 13 to 77 amino acid residues. The shortest form, apelin-13, is the most active one. Apelin is produced by adipose and muscle tissue as an adipokine and a myokine. Experiments on mice have shown multiple beneficial effects of apelin, including slowing the ageing process. In the growing stream of clinical results, there are reports of the beneficial effect of apelin in disorders of energy metabolism, cardiovascular diseases, hypoxic conditions, sarcopenia, obesity, and diabetes mellitus.
Investigation of Fixed Oil of Gallus gallus domesticus for Various Pharmacological Activities
Authors:   Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan, A Nadeem , H Ali ,   Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan, M Anwaar ,   Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan, Q Jabeen ,   Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan
Published: August 2021

Medicinal oils, including fixed and essential oils, are one of the most ancient forms of medicines. Animals and plants are the major source of fixed oils which have been reported to treat various ailments, such as urinary, nervous, respiratory, cardiovascular, musculoskeletal disorders, bacterial, fungal and protozoal infections etc. Medicinal oils, especially of animal origin are; however, ignored and rarely investigated in contemporary modern medical research. This study was aimed to investigate the various pharmacological activities of fixed oil of Gallus gallus domesticus (Egg oil, Fo.Gg). Fo.Gg was investigated for its wound healing potential by using excisional wound model, anti-arthritic activity by following turpentine oil-induced acute arthritis model, antipyretic activity by yeast-induced pyrexia, anxiolytic activity by adopting hole board, light/dark exploration and elevated plus maze models, antidepressant activity by forced swim test and tail suspension model and antiamnesic activity by Y-maze model. Fo.Gg showed significant healing potential as evident from increase in percent wound contraction and decrease in period of epithelialization and also the significant decrease in paw and ankle joint diameter in anti-arthritic activity. It showed dose-dependent (i.e. 10, 30 and 50%) decrease in rectal temperature when compared to the control group, also showed significant anxiolytic, antidepressant and anti-amnesic activities. These pharmacological activities may be attributed to the antioxidant as well as radical scavenging potential of oil components especially polyphenols, oleic acid and linoleic acid. Thus, the results of the study conclude that egg oil possesses wound healing, anti-arthritic, antipyretic, anxiolytic, antidepressant and anti-amnesic potential. The study provides scientific ground for the folkloric use of the oil in traditional system of medicine; however, further studies are required to explore the possible mechanism(s) of action.
Black Carrot (Daucus carota ssp. sativus var. Atrorubens Alef.) Extract Protects against Ethanol-induced Liver Injury via the Suppression of Phosphodiesterase 4 mRNA Expression
Authors:   Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Japan, A Kitano , T Norikura ,   Department of Nutrition, Aomori University of Health and Welfare, Japan, I Matsui-Yuasa ,   Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Japan, H Shimakawa ,   Konan Chemical Industry, Co., Ltd., Japan, M Kamezawa ,   Konan Chemical Industry, Co., Ltd., Japan, A Kojima-Yuasa ,   Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Japan
Published: August 2021

We examined the protective effects of Black Carrot Extract (BCE) on Alcoholic Liver Disease (ALD) using in vivo and in vitro models. In an in vivo ethanol-Carbon Tetrachloride (CCl4)-treated rat model, BCE treatment suppressed serum alanine aminotransferase and aspartate aminotransferase activity. BCE also suppressed ethanol- and CCl4-induced alcoholic liver disease. Furthermore, we observed that the BCE or butanol-extracted fraction of BCE (BCE-BuOH) recovered the cell viability of in vitro ethanol-treated hepatocytes. BCE-BuOH also suppressed the production of reactive oxygen species induced by ethanol to the control level. Moreover, BCE-BuOH regulated the activities of three alcoholic metabolism-related enzymes: cytochrome P450 2E1 activity was suppressed at the posttranslational level, alcohol dehydrogenase activity was increased at the posttranslational level, and aldehyde dehydrogenase 2 activity was increased at the transcriptional level. Novel findings in this study include an increase in intracellular Cyclic Adenosine 3’,5’-Monophosphate (cAMP) levels in hepatocytes with the simultaneous addition of ethanol and BCE-BuOH and the suppression of changes in the activities of three enzymes upon treatment with an inhibitor of cAMP-dependent protein kinase. Our study also found that BCE-BuOH suppressed the expression of phosphodiesterase 4b mRNA, which increased intracellular cAMP levels. These results suggest that BCE is useful for the treatment of ALD.
Cytochrome C and COI Sequence of O.laetus Review
Authors:   Department of Bioinformatics and Biotechnology, Government Collage University, Faisalabad, Pakistan, MW Mazhar , A Raza ,   Department of Bioinformatics and Biotechnology, Government Collage University, Faisalabad, Pakistan, M Sikandar ,   Department of Bioinformatics and Biotechnology, Government Collage University, Faisalabad, Pakistan, J Mahmood ,   Department of Bioinformatics and Biotechnology, Government Collage University, Faisalabad, Pakistan, S Saif ,   Department of Bioinformatics and Biotechnology, Government Collage University, Faisalabad, Pakistan, N Waqas ,   Department of Bioinformatics and Biotechnology, Government Collage University, Faisalabad, Pakistan, H Tahir ,   Department of Bioinformatics and Biotechnology, Government Collage University, Faisalabad, Pakistan, F Mazhar ,   Department of Bioinformatics and Biotechnology, Government Collage University, Faisalabad, Pakistan
Published: August 2021

The COI sequence of O.laetus was submitted to the Genbank database holding an accession number HQ908084 (Figure1). The amino acid sequence of the corresponding COI gene was also updated under the accession number ADZ05746, which turned out to contain 222 amino acids. Base statistics of the O.laetus COI are presented in Figure 2. It can be seen from the table that the fragment is rich in AT content as expected with thymine occurring most frequently followed by the others in the order A, C & G. The AT% stood at 67.2 in comparison to GC% at 32.8. The protein entry was subjected to family confirmation by searching the InterProScan database and the results indicate a very high and significant match confirming our sequence to be a part of Cytochrome C.
Motherhood Plan: Has it Changed in Face of the COVID-19 Pandemics?
Authors:   Fertility Medical Group, Av. Brigadeiro Luis Antonio, Instituto Sapientiae-Centro de Estudos e Pesquisa em Reprodução Humana Assistida, São Paulo, Brazil, DPAF Braga , AS Setti ,   Fertility Medical Group, Av. Brigadeiro Luis Antonio, Instituto Sapientiae-Centro de Estudos e Pesquisa em Reprodução Humana Assistida, São Paulo, Brazil, RMM Melamed ,   Fertility Medical Group, Av. Brigadeiro Luis Antonio, Instituto Sapientiae-Centro de Estudos e Pesquisa em Reprodução Humana Assistida, São Paulo, Brazil, A Iaconelli ,   Fertility Medical Group, Av. Brigadeiro Luis Antonio, Instituto Sapientiae-Centro de Estudos e Pesquisa em Reprodução Humana Assistida, São Paulo, Brazil, E Borges ,   Fertility Medical Group, Av. Brigadeiro Luis Antonio, Instituto Sapientiae-Centro de Estudos e Pesquisa em Reprodução Humana Assistida, São Paulo, Brazil
Published: August 2021

Background: The goal for the present study was to investigate whether women seeking fertility care have different perception concerning the impact of Covid-19 on the motherhood plan than a target population. Material and Methods: For this prospective study, a survey through onlineplatforms was conducted. Participants were randomized by age, in a 1:4 ratio, into: ART-GROUP (n=368), including patients seeking for Assisted Reproduction Treatment (ART), but still didn’t start their cycles or INTERESTED-GROUP (n=92), including participants interested in the subject, who accessed the website of a university-affiliated IVF-center. Information on their perceptions in face of the COVID-19 pandemics and the motherhood plan was collected. Results: When asked about the possibility of becoming pregnant, after the beginning of the pandemic, 47.8% of the ART-GROUP stated to believe the pandemic could affect their plans, while only 28.2% of the INTERESTEDGROUP stated the same. The plan to become pregnant was postponed by 41.3% of the ART-GROUP and by 60.8% of the INTERESTED-GROUP. The main reasons that led people to this decision were fear of getting sick, economic reasons and a pessimist view of the future. Conclusion: In conclusion, besides the fear of becoming sick, the economic burdens are the main reason for the delay in the motherhood plain.
Importance of In Vitro Microenvironment on Differentiation and Translational Applications of Dental Pulp Stem Cells
Authors:   Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, Q Li
Published: August 2021

Dental Pulp Stem Cells (DPSCs) are adult stem cells found in dental pulp tissue, and possess the capacity for self-renewal and the potential for multipotent differentiation. DPSCs depend on regulating in vitro microenvironment, and can readily differentiate into osteoblasts, odontoblasts, neurocytes, adipocytes, chondrocytes, myocytes, fibrocytes and many others. In addition, DPSCs play a crucial role in tooth regeneration, bone and nerve repair in current studies of regenerative medicine and tissue engineering. Among them, the influences of stem cell microenvironment or niche on the biological activity of DPSCs are critical and hamper its progress. Herein, we review the influence of culture condition, tissue source, growth factor requirements, and cellular organizational scaffolds and how these features influence the biological characteristics and translational research of DPSCs.
Preliminary Physico-Chemical Profile of Yashtimadhu Ghrita
Authors: Swathy Vijayakumar  , Mahadevan Subramaniam  , Vandana Rani Madhavan  , Anusree Dileep  , Ramesh Narve Venkatesha  , Delvin Thozhuthumparambil Robin
Published: August 2021

Yashtimadhu ghrita is a single-herbal ghee formulation mentioned in the classical texts of Ayurveda and is indicated in sadya kshatavrana (an acute inflammatory condition or an acute wound associated with trauma). It also minimizes the pain related to the wound. The present study is intended to create a finger print profile of Yastimadhu ghrita through its pharmacognostical identification and the physico-chemical analysis.  The genuineness of the dry specimen of Yashtimadhu (Glycyrrhiza glabra Linn.) was confirmed through organoleptic evaluation and cross-sectional microscopy. Yashtimadhu ghrita was prepared  as per the Sneha paka (preparation of unctuous formulations using ghee, oil etc.) procedure mentioned in Sarngadhara Samhita Madhyama khanda and the standard operative procedures specified in Ayurvedic pharmacopoeia of India. The test result of the finished product shows Acid value 6.7, saponification value 213.4, and Refractive index value1.455 at room temperature, Iodine value 38.7, LOD 0.64. TLC and HPTLC were carried out for the characterization of the plant material in an appropriate solvent system. A total of nine spots were distinguished in 254 nm and five spots in 366 nm during the HPTLC scanning. The Rf value pertaining to the spots were identical in the methanolic extract which indicates the presence of definite constituents in Yashtimadhu ghrita.
Femoroasetabular sıkışma sendromlu hastalarda pelvik bölgenin radyolojik anormallikleri ve klinik sonuçlar
Authors: ERDEM SULTANOĞLU Tuba , ATAOĞLU Sarfinaz , ALTINSOY Hasan Baki , SULTANOĞLU Hasan
Published: August 2021

Amaç: Çalışmamızda femoroasetabular sıkışma sendromlu hastalarda klinik sonuçların ve eşlik edebilen pelvik bölgedeki radyolojik değişikliklerin incelenmesi; kalça ağrılarının etyolojisinde femoroasetabular sıkışmanın ve konservatif tedavinin öneminin vurgulanması amaçlanmıştır. Gereç ve Yöntem: Ağustos 2016-Ağustos 2020 tarihleri arasında femoroasetabular sıkışma sendromu tanısı olan 104 hastanın dosya kayıtları ile sosyodemografik ve klinik özellikleri, abdominal ve pelvik bilgisayarlı tomografi taramaları, pelvik bölgenin magnetik rezonans görüntülemeleri retrospektif olarak incelendi. Bulgular: Hastaların %41.3’ü kadın, %58.7’si erkek ve yaş ortalaması 52.78±13.18 idi. Hastaların %37.5’u ev hanımı; %29.8’i çalışmayan; %28.8’i çalışan ve %3.8‘i öğrenciydi. Kalça ağrısı olan hastaların oranı %76 idi. %31.7’sinde sağ kalça; %22.1 sol kalça ve %22.1’inde her iki kalça bölgesinde ağrı şikayeti mevcuttu. Hastaların %17.3’üne aktivite modifikasyonu ve medikal tedavi; %32.7’sinde medikal tedavi ve ev egzersiz programı; %26.0’ünde fizyoterapi uygulanmış; %24.0'ünde herhangi bir tedavi uygulanmamıştı. Hastaların %54.8’ine tomografi; %45.2’sine magnetik rezonans görüntüleme ile tanı konmuştu. Radyografik bulgulara göre %80.8’inde cam tip; %5.8’inde pincer tip ve 13.5’inde mikst tip femoroasetabular sıkışma vardı. Asemptomatik hastaların %53.7’sinde; ağrı şikayeti olan hastaların %61.8’inde pelvik bölgede ek radyolojik değişiklikler vardı. Her iki grupta pelvik bölgede eşlik eden radyolojik değişiklikler en fazla subkortikal kist ve sklerozdu. Sonuç: Kalça osteoartriti gelişiminde önemli faktörlerden birisi olan femoroasetabular sıkışma sendromu kalça ağrısı nedenleri araştırılırken düşünülmelidir. Erken tanı ve etkin tedaviyle kalça ekleminin korunması, hastanın yaşam kalitesinin arttırılması hedeflenmelidir. Bu amaçlarla fizyoterapi semptomatik femoroasetabular sıkışma sendromlu hastalarda tedavi seçeneği olarak düşünülebilir.
CD45 pozitif ve CD45 negatif neoplastik plazma hücreleri saptanan multiple miyelom olgusu
Authors: GEZER Oya , GÜLÜM Cemil , BOBUŞOĞLU Onur , TOMBAK Anıl , ÇİMEN Mehmet Burak , TAMER Lülüfer
Published: August 2021

Multiple Miyelom (MM) kemik iliğindeki plazma hücrelerinin üretimini etkileyen bir kanser türüdür. B hücrelerinin farklılaşması sonucu oluşan, immunglobulin (antikor) üreten plazma hücreleri miyelom hücresine dönüşünce, antikor yerine monoklonal protein (M-protein) üretirler. Miyeloma hücreleri genellikle CD45 ekspresyonu göstermezler. Bu makalede akım sitometrik immünfenotipleme çalışmasında CD45(+) ve CD45(-) hücreleri birlikte taşıyan bir multiple miyelom vakası sunulmaktadır.
IDEOLOGIA E SOLIDÃO – ATUALIDADE DE HANNAH ARENDT
Authors: Pereira Geraldo
Published: August 2021

O texto revisita, de maneira breve, os conceitos de ideologia e solidão presentes em Origens do totalitarismo. Avança pela demonstração da atualidade das reflexões da autora em torno desses conceitos e aponta para o fato de que eles ainda figuram como categorias importantes para se pensar os desafios do nosso tempo.  Sobre a ideologia, coloca-se destaque na definição arendtiana de lógica de uma ideia, isto é, sobre a forma fria e procedimental de dedução desvinculada das contradições da realidade dos fatos. No caso da solidão, quando pensada na relação política que ela possui no texto de Arendt, o destaque recai sobre a figura, explorada pelos regimes totalitários, de um não lugar.
AS TEMPORALIDADES DE EXCEÇÃO
Authors: Rubiano Mariana Mattos , Rocha Alexandrina Paiva , Farias Junior João Batista
Published: August 2021

O objetivo deste artigo consiste em discutir o conceito de temporalidade de exceção. A partir da leitura de Origens do Totalitarismo notamos o surgimento de uma temporalidade petrificada nos campos de concentração. Mesmo com o fim do regime nazista, os elementos totalitários não desapareceram de nossa sociedade democrática. Eles persistem também como temporalidade de exceção, a qual envolve algum processo de desumanização que desconecta passado, presente e futuro, impossibilitando a experiência da liberdade. Em nossos dias a exceção permanece para milhões de pessoas que vivem na extrema pobreza e encarceradas, numa temporalidade desértica ou embotada que afetam suas atividades da vida ativa e espirituais. Levando isso em consideração, com base no pensamento de Hannah Arendt e também com apoio de outros autores, refletiremos sobre a relação entre a temporalidade, condição e atividade humanas.Totalitarismo; Campos de concentração; Miséria; Prisões; Hannah Arendt.
Pengetahuan Matematis Siswa dalam Materi Bentuk Pangkat dan Akar
Authors: Andika Andika , Mariyam Mariyam , Husna Nurul
Published: August 2021

Tujuan penelitian ini adalah untuk mendeskripsikan persentase kemampuan, bentuk kesulitan, dan faktor penyebab pengetahuan matematis siswa. Jenis penelitian yang digunakan adalah penelitian deskriptif kualitatif. Subjek dalam penelitian ini adalah siswa kelas X SMA Negeri 4 Singkawang dengan jumlah 30 siswa. Pengambilan data menggunakan instrumen berupa tes uraian yang disesuaikan dengan kemampuan kompetensi strategis matematis dan telah diuji menggunakan validasi isi, validasi konstruk, reliabilitas, daya pembeda, dan tingkat kesukaran. Teknik analisis data yang digunakan adalah penskoran, pedeskripsian data, dan wawancara. Hasil Penelitian menunjukan bahwa (1) Persentase kemampuan pengetahuan matematis dari 30 siswa yaitu 39% siswa memiliki tingkat pengetahuan yang tinggi, 11% siswa memiliki tingkat pengetahuan sedang, dan 50% siswa memiliki tingkat pengetahuan rendah. (2) Bentuk kesulitan siswa dalam menyelesaikan yaitu fakta (kesulitan dalam mengenal dan menuliskan fakta), konsep (kesulitan dalam mengenal dan menuliskan konsep), prinsip (kesulitan dalam mengenal dan menuliskan prinsip), dan notasi (kesulitan dalam mengenal dan menuliskan notasi). (3) Faktor yang mempengaruhi kemampuan pengetahuan matematis siswa berasal dari faktor internal yaitu siswa kebingungan atau lupa cara mengerjakannya, tidak adanya motivasi, minat dan tidak memahami soal dengan baik.
Kemampuan Pemahaman Konsep Matematika terhadap Kemampuan Koneksi Matematika Siswa pada Materi Perbandingan
Authors: Wahyuni Rika , Prihatiningtyas Nindy Citroresmi
Published: August 2021

Penelitian ini bertujuan untuk mendeskripsikan kemampuan pemahaman konsep dan koneksi matematika siswa pada materi perbandingan serta menganalisis keterkaitan kemampuan pemahaman konsep terhadap kemampuan koneksi matematika. Metode penelitian ini adalah metode penelitian kualitatif. Subjek dalam penelitian ini adalah siswa kelas VIII B SMP Negeri 14 Singkawang yang berjumlah 22 orang. Data diperoleh melalui tes kemampuan pemahaman konsep dan koneksi matematika serta pedoman wawancara yang tidak terstruktur. Data dianalisis melalui reduksi data, penyajian data, dan penarikan kesimpulan yang mengacu pada pendapat Miles and Huberman. Hasil analisis menunjukkan: (1) tingkat kemampuan pemahaman konsep matematika siswa pada materi perbandingan adalah 2 siswa dengan kemampuan pemahaman konsep tinggi, 7 siswa dengan kemampuan pemahaman konsep sedang dan 13 siswa dengan kemampuan pemahaman konsep rendah; (2) tingkat kemampuan koneksi matematika siswa pada materi perbandingan adalah 1 siswa dengan kemampuan koneksi tinggi, 5 siswa dengan kemampuan koneksi sedang dan 16 siswa dengan kemampuan koneksi rendah; (3) tingkat kemampuan pemahaman konsep matematika berkaitan dengan tingkat kemampuan koneksi matematika dengan rincian indikator menyatakan ulang sebuah konsep berkaitan dengan memahami hubungan antartopik matematika, indikator memberikan contoh dan non-contoh dari konsep matematika berkaitan dengan menerapkan konsep matematika dengan topik disiplin ilmu lainnya serta indikator mengaplikasikan konsep atau algoritma ke pemecahan masalah berkaitan dengan menerapkan konsep matematika dalam kehidupan sehari-hari.
Eksplorasi Konsep Fisika pada Proses Pembuatan Anyaman Tikar Tradisional
Authors: Tamelan Narwasti , Laos Landiana Etni , Boimau Infianto
Published: August 2021

Penelitian ini dilakukan pada Suku Amanatun Selatan khususnya Desa Nenoat dengan tujuan untuk mengetahui konsep-konsep fisika yang terdapat pada tahapan proses anyaman tradisional tikar. Penelitian ini menggunakan penelitian kualitatif fenomenologi dan menggunakan  teknik trianggulasi berupa observasi, wawancara dan dokumentasi. Instrumen dalam penelitian ini adalah peneliti sendiri dan wawancara.Teknik analisis data yang digunakan dalam penelitian ini adalah analisis interaktif. Hasil penelitian diperoleh bahwa pada proses  pembuatan tikar terdapat  konsep-konsep fisika yang dieksplor seperti energi potensial, aksi reaksi, gaya,  gaya gesek, tekanan, usaha, kesetimbangan, gaya berat, gaya normal, kalor, perpindahan kalor secara radiasi, gaya tarik, massa, dan percepatan.
Profil Konsepsi Siswa pada Materi Energi Berdasarkan Analisis Four-Tier Diagnostic Test
Authors: Silitonga Haratua Tiur Maria , Oktavianty Erwina , Hamdani Hamdani , Dendodi Dendodi
Published: August 2021

Penelitian ini bertujuan untuk mendeskripsikan pemahaman konseptual siswa tentang energi berdasarkan analisis instrumen tes empat tingkat. Sampel penelitian ini sebanyak 91 siswa yang diambil melalui teknik purposive sampling dari kelas X tiga SMA Negeri di Pontianak. Data dikumpulkan dengan menggunakan tes diagnostik empat tingkat yang terdiri dari 12 pertanyaan pilihan ganda. Hasil validasi ahli menunjukkan bahwa indeks Aiken-v adalah 0,73. Reliabilitas instrumen sebesar 0,783 dan memiliki tingkat keterbacaan soal 0,63. Hasil yang diperoleh berdasarkan analisis uji diagnostik empat tingkat terdiri dari Siswa Paham konsep (33,2%), Paham sebagian (8,7%), Tidak paham konsep (12,6%), dan Miskonsepsi (45,4%).
The Effect of Tax Risk on Tax Avoidance
Authors: Mangoting Yenni , Yuliana Oviliani Yenty , Effendy Jesslyn , Hariono Lovena , Lians Viennie Melinda
Published: August 2021

This research intends to investigate whether tax risk is associated with tax avoidance, which is proxied by Cash Effective Tax Rate (CETR). Tax risk is measured by six tax risk components: transactional risk, compliance risk, operational risk, financial accounting risk, managerial risk, and reputational risk. The samples in this research are manufacturing companies listed on the Indonesian Stock Exchange (IDX). With a purposive sampling method, there are 168 firm years which we analyzed with OLS regression. The result in this study showed that tax risk is positively associated with CETR. It implied that choices of tax strategies and activities are involved in high tax risk, but firms still choose to comply with tax regulations, which can be seen in high CETR values. This research found that firms need tax risk management to ensure that tax strategies do not impact the firms’ future losses from additional tax payments and fines. Other than that, this research gives a new option for future researchers to measure tax risk using scoring methods and indicators that are engaged in each of the tax risk components.DOI: 10.26905/jkdp.v25i3.5629
Related Party Transactions, Family Ownership, and Earnings Management in Indonesia
Authors: Subastian Levina Ulfa , Widagdo Ari Kuncara , Setiawan Doddy
Published: August 2021

The purpose of earnings management practice is to reach the profit goals the company wants to achieve. Therefore, this study aims to determine the relationship between related party transactions and earnings management in Indonesia by balanced panel data from consumer goods companies listed on the Indonesia Stock Exchange (IDX) from 2017 to 2019. The number of samples used in this study was 102 firm-year observations. The results showed that related party transactions positively and significantly improved corporate earnings management, with discretionary accrual as a proxy. The presence of family ownership strengthens the relationship between related party transactions and earnings management. Also, it shows that the control variable: public accountant from BIG4, company size, company losses, and ROA affect accrual earnings management. The leverage does not affect accrual earnings management. The study result indicates that family business ownership encourages an entrenchment effect that is detrimental to the company. It is carried out through related party transactions then manipulated by using accrual earnings management practices.DOI: 10.26905/jkdp.v25i3.5778
Board Characteristic and Financial Restatement
Authors: Putri Ni Ketut Wahyu , Rustiarini Ni Wayan , Dewi Ni Putu Shinta
Published: August 2021

This study explores the role of board characteristics, namely the Board of Directors (BoD) and the Board of Commissioners (BoC), on the possibility of financial restatement. BoD characteristics were analyzed based on BoD size, female, and overconfidence. Meanwhile, BoC characteristics were analyzed based on BoC size and independent BoC. The population is all manufacturing companies on the Indonesia Stock Exchange for the 2017- 2019 period. Determination of the sample using the purposive sampling method. The number of samples used is 32 manufacturing companies or 96 observational data. This study using logistic regression to hypotheses testing. The results showed that two variables, namely female of BoD and independent of BoC, reduced the possibility of financial restatement. However, three other variables, including BoD overconfidence, BoD size, and BoC size, do not affect the possibility of financial restatement.DOI: 10.26905/jkdp.v25i3.5883
Contributions of the EURO 2020 football championship events to a third wave of SARS-CoV-2 in Scotland, 11 June to 7 July 2021
Authors: Marsh Kimberly , Griffiths Emily , Young Johanna J. , Gibb Carrie-Anne , McMenamin Jim
Published: August 2021

Public Health Scotland used Scottish national contact tracing data to estimate the European football championship (EURO 2020) contributions to a third wave of SARS-CoV-2 infections. From 11 June to 7 July 2021, 2,632 (4%) of 63,874 SARS-CoV-2 cases self-reported attending a EURO 2020 event; 90% were male, of whom 73% were 20–39-year-olds. Most cases attended unofficial gatherings and averaged more contacts than the general population. Targeted guidance on celebrating safely in closed spaces is key.
The Effects of Cognitive Training Program for Older Adults: A Brief Preliminary Report
Authors:   Minnesota State University – Mankato
Published: August 2021

As one ages, some degree of cognitive decline is expected. Despite this, declines in cognitive abilities and the possibility of dementia is a common concern among older adults. In response to these concerns, a variety of cognitive training programs has been developed that aim to improve or maintain cognitive functioning. Prior literature has shown mixed or limited findings on cognitive changes after implementation of cognitive training. This study evaluated the effectiveness of a cognitive training program designed for older adults with no to minimal cognitive decline. The current study included 17 participants who engaged in two one-hour cognitive training sessions each week for 12 weeks. Each session required participants to complete activities that targeted the following cognitive domains: attention, visual and verbal memory, visual spatial skills, processing speed and executive functioning, and language. These cognitive domains, along with depression and memory self-efficacy, were assessed prior to and immediately after completion of the program. Small to large effect sizes on the majority of cognitive outcome measures were observed following participation in the program. Small reductions in depressive symptoms were also found. These findings provide preliminary support for the use of a comprehensive cognitive training program for cognitively-intact older adults.
Marx and Weber’s Polar Opposing Theorical Concepts of Capitalism and Christianity: A Tribute to The Depth of Sociological Theory in the 21 Century
Authors:   Professor Emeritus for Sociology York City College of Technology (CUNY)
Published: August 2021

Abstract: Marx and Weber two German Sociologists with opposite social theories centered around Capitalism and Religion in Western Civilization. Context: This effort is the first in a series of articles designed to expose Sociology’s depth in theorical free social thought. The second article in this series will contrast “Conflict Theory” with “Functionalism”. Marx viewed modern capitalist society as an historical process of oppression and alienation. Indeed, labor is viewed as a commodity, Marx refers to this social conditions as Alienated or Estrange labor. Found in this social position humanity cannot experience a creative function; rather experiences oneself passively as the subject separated from the object. Therefore, the perversion of labor into a meaningless crippling productive force. Furthermore, Marx argued the nature of humanity is to transform, and change nature to fit human needs or “Species-Being”. Therefore, Humanity is the past, present and the future. As opposed to the species-nature of animal. Animal behavior is rooted in the internal repetition of activities, accepting what nature has to offer. However, alienated labor perverts’ human character as “species-being” into a means of existence, rather than a free, conscious creative activity. Moreover, humanity feels free only to act in a most animal function (rather than as a free creative activity decreasing humanities advantage over animals). Thus, productive life is species-life where humanity consciously transforms the outside world into ones’ self-identity. Lastly, private property is the all-summarized expression of alienated labor for humanity is transformed into a commodity, to be owned and used by the Power-elite. Marx labels this “The Theory of Surplus Value”. The equation located in “Surplus value” is as the value of “things” increase there is a direct decrease in the value of humanity. The end-product is always more valuable than the sum of its parts, which by logically includes the devaluation Humanity. Christianity: Marx argued that embedded in the religious dogma of Christianity is the justification of slavery, negative self-contempt, submissiveness, life-long poverty, and the objectification of humanity, all for the benefit power-elite (Capitalist). Thus” RELIGION IS THE OPIUM OF THE PEOPLE”, man (capitalist) create religion for their purposes of exploitation; thus religion “does not make man”, man makes region.
A TRIGA-like subcritical concept for biological waste management (pills, old vaccines etc.)
Authors:   Independent researcher
Published: August 2021

This subcritical concept is framed in a way that allows use in a single room for some electricity production purposes. It involves a tungsten casing and also helps using depleted uranium dust. The single series of anneals for closure and direct laying of the top opening window onto the left side of the tungsten casing make pressure work impossible ; it also allows for a relatively cheap production.
Innovative solutions to increase productivity, safety and reliability of agricultural products processing equipment
Authors: Shkrabak Vladimir Stepanovich , Orlov Pavel Sergeevich , Morozov Vadim Vladimirovich , Shkrabak Roman Vladimirovich , Krupka Elena Sergeevna
Published: August 2021

It is noted that the agro-industrial complex is a stable supplier of food for the population and raw materials for various types of economic activities. In addition, works related to sawing of various solid materials (wood, plastic masses, frozen meat and fish products, bones and others are characteristic. The equipment used in this case is characterized by metal capacity, insufficient productivity and low reliability, increased injury hazard. In addition, wood sawing equipment is expensive and high-energy. In connection with the present, based on the study and analysis of the situation, the authors proposed an author's solution that allows reducing the shortcomings of existing equipment by half, providing an increase in productivity, reliability and safety in operation. This is facilitated by innovative design solutions, providing, in particular, sawing of materials when the saw block moves not only downwards, but also upwards according to the principle of a crank mechanism. The following material is devoted to the presentation of the design and principle of the proposed innovative solution.
Prevention of injuries in concurrent collision of vehicles in AIC technological pro-cesses
Authors: Shkrabak Roman Vladimirovich
Published: August 2021

The results of research on the prevention of road accidents when carrying out cargo transportation of agro-industrial products as a result of collisions of vehicles moving in the same direction or hitting a standing vehicle or an obstacle are given. It is noted that this situation occurs due to the density of traffic on general roads, as well as on field and country roads characteristic of agricultural production for reasons of low adhesion coefficient in rainy weather, snowfall, ice. In such conditions, a vehicle moving in a stream behind the leader (especially low-clearance ones, such as cars) collides with the rear of the upcoming high-sized transport. The consequences of these collisions are the destruction of the front of the transport moving behind the leader and the injury to the driver and passengers (especially those sitting in the front seat). In order to avoid such situations, an innovative solution is proposed that automatically eliminates the possibility of injury and damage to the rear of the leader and the front of the vehicle colliding with him moving behind the leader.
Study of power of humus profile of soil catens of central forest-steppe
Authors: Kovalyova Elena Vladimirovna , Vagurin Ivan Yuryevich , Akinchin Alexander Vladimirovich , Kuzmina Olga Sergeevna , Teteryadchenko Alexey Ivanovich
Published: August 2021

The article presents the result of a field study to study the power of humus profiles of gray forest soils and black soils of landowned different terms of agricultural use of soil catens of broad-leaved forest (background) and meadow-steppe sections of the Belgorod region. The work was carried out in the spring-summer period 2018-2019. The object of the study was different-age arable areas with an age of agricultural development of 100 and 160 years, respectively. The surface slope in the sections did not exceed 5-60. It was established that the power of the humus profile under the influence of agricultural processing over a 60-year period decreased by 49 cm, moreover, on the slopes of the northern exposition, this indicator is more pronounced (33 cm) than on the slopes of the southern exposition (16 cm). It can be noted that with an increase in the age of agricultural use on the slopes of the northern and southern expositions, the largest thickness of the humus horizon is observed on abnormal soils (72 and 65 cm, respectively). Within the background catens, the soil cover is homogeneous; a second humus horizon was observed in each of the studied sections.
A new direction for obtaining water and hypochlorite solution to fight patho-gens and viruses
Authors: Naumova Olga Valerievna , Chesnokov Boris Pavlovich
Published: August 2021

The article presents the design of the proposed installation for the treatment and disinfection of various objects, as well as the results of experimental studies on the feasibility of exposure to high-voltage pulsed discharge on water and hypochlorite. Experiments have shown that water and hypochlorite solution subjected to electrohydraulic treatment can effectively fight against bacteria, fungi and viruses. The use of electric pulse technology, due to which various forms of oxygen, hydrogen and hypochlorous acid appear that can damage microbial cells, makes it possible to increase the effectiveness of disinfection of any objects at lower energy costs.
IMPACT OF TOURISM ON JAMMU & KASHMIR ECONOMY
Authors: Iqbal Junaid
Published: August 2021

Tourism across the world is playing a great role in building the economies. Tourism is widely used for building the economic development and economic prosperity around the globe. Tourism sector is growing day by day and helping nations to build the economic prosperity of the country. Nations around the world are investing lot of money in building great infrastructure for tourism, so that they can attract tourists from around the world. & Kashmir is one of the leading tourist destinations where tourists love to be. It is that around 50%-60% people of the state are directly or indirectly related with the tourism. and Kashmir economy is a service economy where majority of revenue is coming from tourism sector. In this paper the topic of discussion was to know the impact of tourism on Jammu and Kashmir economy. Apart from that simple regression is used to know the impact of tourism on economy while taking the factors like GDP, EMPLOYMENT and PER-CAPITA INCOME. The results of the analysis were very tremendous it shows that tourism has significant impact on the factors which has been taken as a part of paper.
There is a need to build more facilities and to work on some flaws. Tourists around the world love to visit the state because the state is blessed with the beauty of nature. The state should focus towards the infrastructure development so that more and more tourists visit every year.
Library Impact Practice Brief: Relationship between Library Collections and the Recruitment and Retention of Faculty at UT Austin
Authors: Chiochios Maria , Hedstrom Janelle , Pierce Meyer Katie , Rader Mary
Published: August 2021

As part of the Association of Research Libraries (ARL) Research Library Impact Framework initiative, The University of Texas (UT) at Austin Libraries conducted a study to examine the impact of library collections on the recruitment and retention of faculty to the university, and to understand the relationship between institutional resources—especially libraries—and career decision-making of faculty. This practice brief describes the UT team’s literature review and the data gathered through an online survey and one-on-one semi-structured interviews with newly recruited and newly promoted faculty members.
Aproximación psicosocial a la Adultez Mayor en Chile y algunos desafíos teóricos
Authors: Moyano Díaz Emilio
Published: August 2021

Se revisa literatura acerca de la adultez mayor (AM) en Chile como parte del desarrollo psicológico normal, sus características y desafíos y contextualizada socioculturalmente. Se efectúa una caracterización sociodemográfica de este colectivo en crecimiento y se resumen algunas ideas centrales de las políticas sociales al respecto. Las personas de más de 60 años constituyen alrededor del 17% de la población chilena y representarán el 33% en 2050, aumentando los mayores de 79 años de 2,6% a 8,7% de la población. Desde la teoría de los ocho estadios del desarrollo psicosocial de E. Erikson, y su actualización y extensión hacia una novena y última etapa denominada “gerotrascendencia”, iniciada aproximadamente hacia los 75-80 años y hasta la muerte, se examinan los desafíos propios de la adultez mayor, se entregan algunas claves para una mejor calidad de vida en la vejez y algunas interrogantes para futuros estudios psicológicos en el tema.
Reflexiones en torno a las TIC’s y el Psicodiagnótico en Habilidades y Competencias Parentales
Authors: Jiménez Francisco , González Katherine , Vergara Javiera , Letelier Paloma , Díaz Marcela , Aránguiz Katherinne , Ramírez Andrés , González Karen
Published: August 2021

Dado el contexto de pandemia producto del COVID-19, los procesos de evaluación psicológica han tenido que adaptarse a un modelo predominantemente de teletrabajo, trayendo una serie de limitaciones e innovaciones en el ámbito clínico y forense. El área de Psicodiagnóstico Judicial de CEAC no ha sido la excepción, los profesionales han tenido que adaptar su forma de evaluación al uso de plataformas digitales, enfrentando la problemática de no tener validación científica para el uso de Test de Rorschach en este medio. El equipo optó por descartar la aplicación online del test momentáneamente, pero la interrogante queda abierta para futuras investigaciones.
Objective Synoptic Weather Classification on Air Pollution during Winter Seasons in Hangzhou
Authors: Zhao Jiaqi , Wang Chenggang
Published: August 2021

Using the 2015-2018 Hangzhou city PM2.5, PM10, SO2, CO, NO2 and O3 mass concentration data, ERA5 reanalysis data and ground observation data, through the PCT classification method, the objective analysis of the winter air pollution weather situation in Hangzhou was obtained. The results showed that the winter air quality concentration in Hangzhou continued to be high from 2015 to 2018, and the air pollution was the most significant. Through objective classification, it is concluded that the main weather conditions affecting the region in winter are divided into 6 types, namely high pressure control, high pressure bottom control equalizing field, L-shaped high pressure control, high pressure front control equalizing field, low pressure control, low pressure front control Equalizing field. Among them, when high pressure control, high pressure bottom control equalizing field, L high pressure control, low pressure control are affected by local sources, the impact of external sources has a greater impact on the air quality in Hangzhou, and air pollution is prone to occur; before low pressure When the pressure equalization field is controlled by the Ministry and the pressure equalization field is controlled by the high pressure front, the local wind and precipitation in Hangzhou are relatively high, which is not conducive to the accumulation of air pollutants. The probability of occurrence of air pollution is small, and air pollution is not easy to occur.
Recent development in novel drug delivery systems for delivery of herbal drugs: An updates
Authors: Prajakta N. Dongare  , Anuja S. Motule  , Mahesh R. Dubey  , Manisha P. More  , Prerna A. Patinge  , Ravindra L. Bakal  , Jagdish V. Manwar
Published: August 2021

In the recent years, herbal medicines have gained worldwide attention of peoples and researchers due to their esthetic value, more patient’s compliance and prominent therapeutic effects. Novel drug delivery systems for delivery of herbal drugs possesses several advantages over conventional formulations. It includes enhancement of solubility, bioavailability, and protection from toxicity, etc. The herbal drugs can be used in a more upright course with enhanced efficacy by incorporating them into suitable dosage forms. This can be achieved by designing novel drug delivery systems for such drugs. Such systems are polymeric nanoparticles, nanocapsules, phytosomes, animations, microsphere, etc. The present article highlights the current condition of the development of novel herbal formulations and summarizes their type of active components, biological activity, and applications of novel formulations.
A RESONANCE-BASED THROUGH-TUBING CEMENT EVALUATION TECHNOLOGY
Authors:   GOWell International LLC, Li Jie , Yang Qinshan ,   GOWell International LLC, Zhao Jinsong ,   GOWell International LLC, Olson Jeff ,   GOWell International LLC, Rourke Marvin ,   GOWell International LLC, Zeghlache Mohamed Larbi ,   Saudi Aramco–EXPEC Advanced Research Center
Published: August 2021

Through tubing cement evaluation in a multi-string well has been considered as a cost-efficient way for well integrity evaluation without removing the production tubing. Conventional acoustic cement bond logging methods are not able to operate accurately with the multi-string structure due to an extremely low sensitivity and Signal-to-Noise (SNR) ratio. Therefore, it is important to develop novel technology and apparatus that can accurately and efficiently monitor the cement condition in the multi-pipe cased well. Applications would include use in production, injection, and storage well configurations as well as for plug and abandonment planning. To this end, a novel through-tubing cement evaluation technology based on a Selective Non-Harmonic Resonance (SNHR) is proposed. Unlike the traditional acoustic wave propagation method (WPM), the new tool emits continuous energy to excites the SNHR of the multi-string structure, considered to be a multi-degree of freedom Duffing system. This includes coupling of the hydraulic pressure in fluid and elastic stress-strain of solid materials. The continuous sinusoidal excitation from the SNHR tool drives the structure in a long burst mode and measures the resonance power loss due to the energy leaking through the cement layer, to represent the casing-cement bond, as well as cement-formation bond condition. The SNHR tool, therefore, has overcome the main challenge, which is the acoustic energy reflections and dissipation through multiple interfaces for existing WPMs. The SNHR tool was validated theoretically and experimentally. Results showed that the SNHR tool can reach high sensitivity (> 10%) and SNR (>10 dB) for variable combinations of pipe sizes up to 14”. This implies that the SNHR is a promising technique for evaluating cement bond integrity in the annulus of an outer-most pipe string when multiple inner pipes and their associated annuli are liquid-filled. In addition, the SNHR tool does not require direct coupling to the first pipe string through pads or extensions, which reduces the engineering complexity of a field-worthy instrument.