bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Worksheets Based on Guided Inquiry on the Production of Hand Sanitizer from Mahonony Seed Extract (Swietenia mahagoni)
Authors: Afriani Rolina , Rahmatullah Saepudin , Sukmawardani Yulia
Published: April 2024

This research aimed to develop a worksheet based on guided inquiry on colloidal class learning material. Hand sanitizer is one application of the colloid system. In this study, a hand sanitizer was made using an additional ingredient of mahogany seed extract as an active substance to replace alcohol as an antibacterial. The purpose of this study was to compile and determine the results of a guided inquiry-based worksheet validation test. The research method used was Design-Based Research (DBR). The results of the validation test by expert lecturers were declared valid with an average r-count value of 0.860. The worksheets produced are in accordance with the stages of guided inquiry-based learning and are feasible to be applied to colloid subjects in class XI science with a r-count of 0.83. The hand sanitizer produced was in accordance with SNI 2017 with a pH range of 6-8. This worksheet can later be applied in practical waste management and treatment.
Keywords: worksheet, guided inquiry, hand sanitizer
Developing a Hydrocarbon Electronic Book to Develop Students Critical Thinking Skills Through the 4S TMD Method
Authors: Lubis Nurjannah , Anwar Sjaeful , Sumarna Omay
Published: April 2024

This study aimed to develop an electronic book on hydrocarbon study materials using the Four-Steps Teaching Material Development (4S TMD) method to develop students’ critical thinking skills. To achieve this goal, an electronic book was developed using the 4S TMD method, which will be tested using the Development Research (DR) research method which consists of three stages: design, development, and evaluation. At this stage the study was the first part of the development of teaching materials which consisted of four stages: selection, arrangement, characterization, and didactic reduction. The results of the research were focused on the selection stages. At the selection stage, the development of teaching materials begins with the development of learning indicators, the development of the concept of hydrocarbons based on curriculum demands, the development of basic concepts sourced from international textbooks, and finally, the development of skills that can be integrated with the concept of hydrocarbons. The results of the selection stage were evaluated by expert lecturers in the field of chemistry education.
Keywords: electronic book, hydrocarbon, 4S TMD, critical thinking skills
Development of Student Worksheets on Biosorbent Synthesis from Papaya Seeds (Carica papaya L) for Dye Absorption in Batik Industry Liquid Waste
Authors: Sukmawardani Yulia , Tsaqil Abdul Aziz Putri , Aisyah Riri , Zenab Subarkah Cucu
Published: April 2024

One of the causes of environmental pollution in Indonesia is inappropriate waste treatment, particularly batik industrial wastewater. Lack of awareness and public knowledge regarding waste management are things that support pervasive pollution. One way to educate students about this issue is through worksheets that teachers can use to teach how to treat waste properly and correctly. This study aimed to describe the arrangement of student worksheets and to analyze the results of a validation test. The steps used in the student worksheets on the manufacture of biosorbents from papaya seeds (Carica papaya l) for the absorption of dyestuffs from the batik industry’s liquid waste were based on guided inquiry. The method used is Design-Based Research (DBR) in three stages: analysis, design, and development. The instruments used were a validation questionnaire using correlation analysis techniques and a student worksheet based on guided inquiry. The results of the student worksheet validation test obtained an average value of 0.80, which states that the student worksheets are valid and can be used as a medium for learning or practicum activities.
Keywords: environmental pollution, wastewater, biosorbents, papaya seeds
The Development of Electronic Modules (E-Module) For Learning Chemical Safety and Security in High School Laboratories
Authors: Hairishah Nazrisya , Nurjayadi Muktiningsih , . Afrizal
Published: April 2024

The use of e-learning was very helpful in the distance learning process that was implemented during the COVID-19 pandemic. One of the applications of e-Learning media that can be used is the electronic module (e-Module). The purpose of this study is to develop electronic modules (e-Module) on chemical safety and security in high school laboratories. This study uses a descriptive quantitative method with research and development outlined by Borg and Gall. The instrument used in this study was a questionnaire. The e-Module was validated by experts in media and graphics, and experts in content and language. The e-Module was also tested by chemistry teachers, students in 10th grade, and college students in the chemistry education program. The result from the assessment given by experts, teachers, and students from the validation and trial stage can be interpreted as well up to very good. It can be concluded that the e-Module is feasible to be used as a learning media of Chemistry on Chemical Safety and Security in High-School Laboratories for high-school students.
Keywords: electronic module, chemical safety, security
Organology Analysis of Dol Musical Instruments as a Mathematics Learning Media Based on the Local Wisdom of Bengkulu in Elementary School
Authors: Parmadi Bambang , Dalifa Dalifa , Agusdianita Neza , Syaqki Parmadie Aliffarazzi
Published: April 2024

The research was held back by the unique background of the Dol instrument as ritual music at the ceremony of the Tabut and the identity of the Bengkulu traditional music. The purpose of the study is to describe the organology of the Dol instrument and its method of production and describe the design of the implementation of musical instruments on mathematics learning materials in elementary schools in both physical and sociocultural detail. The theory used is ethnomusicology and mathematics learning media. The method used is case analysis, which requires a qualitative and quantitative descriptive approach to the organology of the Dol musical instrument and learning media. The data sources used are their sources and a validator with observation techniques interview techniques, and documentation techniques. The validity of data uses their types of triangulation (technique, source, and time). The result of this research was either a text box or a materials module. The result of the Dol instrument’s organological analysis as a media learning mathematics based on local cultural wisdom at the elementary school is expected to assist every teacher in educating students in understanding the preservation of local culture and implanting the local area’s cultural arts character. Besides, the results of this study will contribute to the literacy and media sources of common education and general education.
Keywords: bengkulu, dol musical instruments, elementary school, local wisdom, mathematics learning media, organology analysis.
The Effectiveness of Learning Google Meet Assisted by the Geogebra Application to Improve Students' Understanding of Mathematical Concepts
Authors: Lisnawati Nina , Kariadinata Rahayu , Nurhayati Rahayu Yayu
Published: April 2024

Due to the Covid-19 pandemic, online learning has decreased the comprehension of students’ mathematical concepts.. It is very important to instill conceptual understanding in students, in order for them to think and solve problems correctly and appropriately. Students experience difficulties in learning and understanding mathematical concepts, especially when the material provides changes to different problems. This paper aims to find out how far the effectiveness of Google Meet learning is achieved with the help of the GeoGebra application to improve students’ understanding of mathematical concepts. This study uses a quasi-experimental method with sampling using a simple random sampling technique. This research was conducted in one of the high schools in the city of Bandung with the selected sample being class XI MIA 5 as the experimental class, while XI MIA 3 as the conventional class. The instrument used was the Mathematics Preliminary Knowledge test, which is a test of the ability to understand mathematical concepts. This shows that there is an increase in the ability to understand students’ mathematical concepts between the experimental class and the control class. Learning mathematics through Google Meet assisted by the GeoGebra application provides opportunities for students to be able to actively participate in mathematics learning activities through graphic visualization media. It also fosters interest, enthusiasm, and motivates the students in improving their conceptual understanding of mathematics.
Keywords: geogebra application, google meet, understanding of mathematical concepts
The Online Game Design Uses Scratch, Geogebra, and Geogebra AR Through Mathematics Education Multimedia Lectures
Authors: Sudihartinih Eyus , Rachmatin Dewi
Published: April 2024

This study aims to design online mathematics games using Scratch, Geogebra, and Geogebra AR through multimedia education mathematics courses. This study used the multimedia development life cycle. Participants in the study were 41 students (13 male and 28 female) of fifth-semester in a multimedia course in mathematics education at a university in West Java, Indonesia. The research instrument was a questionnaire through Google Forms, performance appraisal, observation, and interviews. Based on the research results it is known that Scratch, Geogebra, and Geogebra AR can be used in math game design even though previous students have not studied both, but the results are good. The author suggests that students can try out these math games at school during research or teaching practice. In addition, the authors hope that the game can be published on the internet so that it can be used by many students.
Keywords: game online, scratch, geogebra AR
Lateral Thinking Ability Through Challenge-based Learning with Sparkol Videoscribe
Authors: Susilawati Wati , Yaniawati Poppy
Published: April 2024

Online learning during the Covid-19 pandemic was very interesting to observe because learning can be done anytime and anywhere. However, Covid-19 has an impact on the learning process in schools and students’ thinking abilities. The purpose of this paper is to analyze the differences in the improvement of mathematical lateral thinking skills between students who received challenge-based learning through sparkol videoscribe and those learning through WhatsApp. The research method used was a quasi-experimental, non-equivalent control group design. The sample was randomly selected from four parallel high school classes in the city of Bandung, namely class X 1 who learned through videoscribe sparkol and class X 3 who studied via WhatsApp. The instrument used is a test of mathematical lateral thinking ability and a test of prior mathematical knowledge. Data analysis was done using two-way ANOVA. Findings: A difference was observed in the achievement of mathematical lateral thinking skills between students who carry out learning through sparkol videoscribe better than those learning through WhatsApp based on prior knowledge of mathematics in the smart, medium, and low categories. Challenge-based learning sparkol videoscribe makes it easier for students to understand the material, the construction process, interaction, and reflection, thereby increasing the ability to think mathematically, laterally.
Keywords: lateral thinking ability, challenge-based learning, sparkot videoscibe
Analysis of Critical Thinking Skills Improvement Through App Inventor-based Learning Media on Sound Wave Topic
Authors: Malik Adam , Munifah Assani Qorry , Handayani Wahyuni , Minan Chusni Muhammad , Yuniarti Suhendi Herni
Published: April 2024

This study aims to analyze the improvement of critical thinking skills using learning media development based on App Inventor on sound wave topics. The research was quasi-experimental with a non-equivalent control group design. The research population were students of class XI MIPA in one of the senior high schools in West Java Province. The sampling technique used was random sampling. Class XI MIPA 5 as the experimental class, used App Inventor-based media, and class XI MIPA 2 as the control class used Google Classroom media. The number of students in both categories were 35 each. The research instrument used a critical thinking skill test. The analysis technique uses n-gain and t-independent sample tests. The results showed an increase in students’ critical thinking skills in the experimental class by 0.67 in the moderate category and the control class by 0.46 in the medium type. The results of the t-independent sample test shows the value of tcount?? > ttable ??. Thus, there is a difference in improving students’ critical thinking skills between learning using App Inventor-based media and using Google Classroom media on sound wave topics.
Keywords: critical thinking skills, app inventor-based learning, sound wave.
Students' Perceptions in Developing Authentic Assessment with Website Integrated to Measure Physics Learning Outcomes: A Need Analysis
Authors: Ihsan Nurrahman Ahlun , Sukarmin Sukarmin , Suharno Suharno
Published: April 2024

Assessment is one of the crucial roles in measuring student abilities to face challenges of the 21st century. This study examines how college students’ ambitions influence their perceptions and desires for authentic assessment, based on website development. Data series via interviews and closed query questionnaires were given to 131 high school students within the metropolis of Surakarta. Facts analysis used a qualitative method with descriptive strategies. The findings of this look suggest that 64% of 130 senior high school students find it tough to clear up physics questions. Students experience that they consider physics issues harder to resolve than the equations that have been memorized. Students want within the evaluation, they have experienced those actual troubles within the learning system so that the ability to understand principles, abilities, and attitudes can be higher. Therefore, it is far essential to expand real assessment as an incorporated device between getting to know and evaluation of getting to know to degree physics learning outcomes.
Keywords: authentic assessment, website integrated, physics learning outcomes
Providing STEM Opportunities Skill Through Making Biodegradable Plastic Projects in Extracurricular Activities
Authors: Choiriyah Meiliana , Perdana Sriyansyah Syakti , Ponco Sumanto Nugroho
Published: April 2024

The students are prepared to face the global challenges and have a strong desire to act with striving and excellent character values, nowadays. Providing STEM during extracurricular activities can offer the opportunity for students to gain skills that are needed to address the challenges. STEM as a part of the science learning process contributes to increasing the experimental learning skill for the students’ academics. Thus, we implemented STEM learning through making a biodegradable plastic project that involved students and teachers during extracurricular activity. To achieve our goal in providing STEM learning, we used nonexperimental and experimental activities. Nonexperimental activities were done by study literate, and discussion and experimental activities were done by students experiment in the laboratory to design, construct, and test the project that students made. We used students post-activity survey and students perspectives in STEM participating learning during extracurricular as the STEM success indicator. They agreed that STEM learning can increase knowledge of post-schooling opportunities and it can develop students’ interest and talent in STEM competitions.
Keywords: STEM, biodegradable plastic, extracurricular activities
Implementation of Computational Thinking through Game-Based Learning: A Systematic Literature Review
Authors: Candrawati Emilia , Eko Sardjono Ratnaningsih , Rohman Ijang , Kurnia Prahani Binar
Published: April 2024

Computational thinking (CT) is one of the 21
Neural Network Approaches for Early Breast Cancer Detection
Authors: Al-Shamasneh Ala’a R. , Alabdulkarim Nadia , Ahmad Maya
Published: April 2024

Research on breast cancer is crucial due to its significant impact on public health, with high mortality rates underscoring the urgency for improved diagnostic methods. Early detection plays a pivotal role in enhancing treatment outcomes and reducing mortality rates. This paper addresses the pressing need for more effective early disease detection methods, particularly focusing on breast cancer diagnosis. It proposes the utilization of neural networking techniques, known for their potential to enhance accuracy and efficiency in cancer diagnosis. The study aims to provide a comprehensive overview of breast cancer detection using neural networking, emphasizing its significance in improving patient outcomes. By showcasing the effectiveness of neural network approaches, the research contributes to advancing early cancer detection efforts, aligning with global health initiatives prioritizing early diagnosis and intervention.
Interêt de la Refraction Sous Cycloplegie chez l’Adulte Jeybe a Citonou
Authors: Aïgbe Nestor , Todome F. , Abouki Coa , Alfa Bio Issifou A. , Assavedo Cra , Odoulami L.
Published: April 2024

Les vices de réfraction ou amétropies sont représentés par toutes les situations où le système optique de l’œil ne permet pas de focaliser l’image d’un objet sur la rétine. Cette recherche se voulait d’étudier les variations de la réfraction sous cycloplégie chez l’adulte jeune. Elle était rétrospective sur 05 ans à l’ex Hôpital d’Instruction des Armées – Centre Hospitalier Universitaire de Cotonou considérant 2224 yeux de patients âgés de 18 à 38 ans respectant les critères d’inclusion. La régression linéaire a été utilisée en vue d’étudier la relation entre la puissance des sphères, du cylindre et l’équivalent sphérique avant et après la cycloplégie. L’âge moyen des patients était de 27,2 ans ± 6,1. Les céphalées représentaient 56,1% des motifs de consultation et la douleur oculaire 51,8%. Avant la cycloplégie, on comptait 57,7% de myopes et 29,8% d’hypermétropes ; après la cycloplégie, 20,5 % de myopes et 74,1% d’hypermétropes. À partir des équivalents sphériques, la variation moyenne de la puissance des sphères était statistiquement significative (p < 0,0001). Elle était de 0,14 D chez les myopes, de 0,26 D chez les hypermétropes. La cycloplégie a une influence significative sur l’équivalent sphérique dans toutes les tranches d’âge jusqu’à 38 ans (p < 0,0001). L’estimation de la réfraction sans cycloplégie n’est donc pas précise. En effet, la cycloplégie en relâchant l’accommodation permet d’estimer de façon pertinente la valeur exacte et précise de la réfraction. Refractive errors or ametropias encompass situations where the optical system of the eye fails to focus the image of an object onto the retina. This study aimed to investigate variations in refraction under cycloplegia in young adults. It was a retrospective study conducted over a period of 5 years at the former Military Teaching Hospital - University Hospital Center of Cotonou, involving 2224 eyes of patients aged 18 to 38 years who met the inclusion criteria. Linear regression was employed to examine the relationship between the power of spheres, cylinders, and spherical equivalent before and after cycloplegia. The average age of patients was 27.2 years ± 6.1. Headaches accounted for 56.1% of the reasons for consultation, and ocular pain for 51.8%. Before cycloplegia, 57.7% were myopic, and 29.8% were hyperopic; after cycloplegia, 20.5% were myopic, and 74.1% were hyperopic. Based on spherical equivalents, the average change in sphere power was statistically significant (p < 0.0001). It was 0.14 D for myopes and 0.26 D for hypermetropes. Cycloplegia had a significant influence on the spherical equivalent across all age groups up to 38 years (p < 0.0001). Therefore, estimating refraction without cycloplegia is not accurate. Indeed, cycloplegia, by relaxing accommodation, allows for a relevant estimation of the exact and precise value of refraction.
Histórias Oxfordianas: relato de um então jovem docente da Faculdade de Medicina da UFC sobre sua pós-graduação no exterior
Authors: Vale Marcus Raimundo
Published: April 2024

Este é um relato da minha experiência, entre os anos de 1979 e 1983, em busca de qualificação acadêmica em um renomado ambiente científico, no exterior, que visava uma vivência para internacionalização desta Faculdade de Medicina. Este texto foi inspirado por conversas com colegas professores da Faculdade de Medicina e da Seara da Ciência. Tem foco na minha experiência no Departamento de Farmacologia da Universidade de Oxford, onde foi desenvolvido o meu trabalho de Doutorado, como bolsista do Conselho Britânico (The British Council), no laboratório do Dr. Derek Hope. São relatadas as circunstâncias especiais que me levaram a continuar num estágio de Pós-Doutoramento, no mesmo laboratório, nessa etapa com suporte do CNPq. A narrativa se inicia com a minha experiência em Chester, cidade para onde o Conselho Britânico me enviou para uma imersão total na língua inglesa e nos costumes britânicos. Continua com a escolha do tema de minha tese, seu desenvolvimento, as angústias e as vitórias, a vida na universidade, o sistema de colleges, passando pelo relacionamento com professores e colegas britânicos e brasileiros. Especial ênfase é dada ao meu relacionamento com o Professor Hugh Blaschko, eminente farmacologista e bioquímico, a quem devo momentos de grande prazer quando me contava sua experiência como cientista na Alemanha nazista, sua amizade com Hans Krebs e outros grandes cientistas judeus alemães e sua ida para a Inglaterra, para trabalhar na Universidade de Oxford.
An Innovative Deep Learning Approach for Image Semantic and Instance Segmentation
Authors: Chen Chuangchuang , Gao Guang , Liu Linlin , Qiao Yangyang
Published: April 2024

In this study, we propose a segmentation model based on convolutional neural networks (CNNs) to address image segmentation challenges in computer vision. Prior to designing the model, the activation function and other modules of the convolutional neural network were optimized to meet specific requirements. The segmentation task was transformed into binary classification problem to simplify network calculations and improve efficiency. Additionally, the model utilized a mask map obtained from the semantic segmentation model to aid in instance segmentation. Class activation technology was introduced to extract feature mapping maps. The corresponding thermal maps were obtained to achieve target instance segmentation. To further validate the effectiveness of the segmentation model, simulation experiments were conducted on semantic segmentation and instance segmentation respectively. The results show that the accuracy of the basic semantic segmentation model reached 87.58%, while the average accuracy of the entire class of the optimized instance segmentation model reached 97.9%. Therefore, the research and design of image segmentation models demonstrate high accuracy and good robustness.
Sustainability and Corporate Reporting using ERP Systems: Challenges and Opportunities for the Accounting and Auditing Profession
Authors:   Bucharest University of Economic Studies, Romania, BARNA Laura Eugenia Lavinia , IONESCU Bogdan Stefan ,   Bucharest University of Economic Studies, Romania, IONESCU-FELEAGA Liliana ,   Bucharest University of Economic Studies, Romania
Published: April 2024

As a result of the massive digitalization of recent years, ERP systems have started to play an important role in the life cycle of an organization, raising a number of challenges and opportunities especially for the accounting and auditing profession. The accounting and the auditing professions represent two very versatile professions as a result of the changes that have taken place from the moment of their appearance until now, they are constantly improving with the evolution of digitalization. Digitalization has led to the development of accounting and auditing organizations and of course to the focus of attention on sustainability processes and how their corporate reporting is done. The many advantages that ERP systems offer to professional accountants and auditors, as well as other categories of users, have influenced many organizations to resort to the implementation of these systems. Thus, to highlight the main challenges and opportunities that ERP systems offer to the accounting and auditing profession from the perspective of how to ensure sustainability and corporate reporting, the authors performed a quantitative bibliometric analysis, selecting a sample of Web of Science cited articles. The results indicated that ERP systems have a major impact on the decisions adopted by organizations, more specifically they ensure a true picture of the organization's situation, having a significant influence on the way of corporate reporting and on sustainability.
In Silico Search for Drug Candidates Targeting the PAX8–PPARγ Fusion Protein in Thyroid Cancer
Authors: Sakaguchi Kaori , Okiyama Yoshio , Tanaka Shigenori
Published: April 2024

The PAX8/PPARγ rearrangement, producing the PAX8–PPARγ fusion protein (PPFP), is thought to play an essential role in the oncogenesis of thyroid follicular tumors. To identify PPFP-targeted drug candidates and establish an early standard of care for thyroid tumors, we performed ensemble docking-based compound screening. Specifically, we investigated which pocket structure should be adopted to search for a promising ligand compound for the PPFP; the position of the ligand binding pocket on the PPARγ side of the PPFP is common to that of PPARγ; however, the shape is slightly different between them due to environmental factors. We developed a method for selecting a PPFP structure with a relevant pocket and high prediction accuracy for ligand binding. This method was validated using PPARγ, whose structure and activity values are known for many compounds. Then, we performed docking calculations to PPFP for 97 drug or drug-like compounds with a thiazolidine backbone, which is one of the characteristics of ligands that bind well to PPARγ, registered in the DrugBank database. Furthermore, the binding affinities of promising ligand candidates were estimated more reliably using the molecular mechanics-Poisson–Boltzmann surface area method. Thus, we propose promising drug candidates for the PPFP with a thiazolidine backbone.
Microstructural and Hydrophilic Properties of Polylactide Polymer Samples with Various 3D Printing Patterns
Authors: Lenshin Aleksandr S. , Frolova Vera E. , Kannykin Sergey V. , Domashevskaya Evelina P.
Published: April 2024

The aim of the work is to study the effect of the 3D printing process on the microstructural and hydrophilic properties of polylactic acid (PLA) samples with various model printing patterns obtained from the black Filament PLA by sequentially applying polymer layers using the FDM (Fused Deposition Modeling) method. X-ray phase analysis revealed partial crystallization of PLA polymer chains in printed samples, which occurs under thermal and mechanical action on the original amorphous PLA filament during 3D printing to varying degrees, depending on the geometry of the pattern and the morphology of its surface. At the same time, IR spectroscopy data indicate the preservation of all intrastructural chemical bonds of polylactide. Measured at the original installation, the values of the wetting edge angles on the surface of the printed samples are in the range φ = 50-60°, which is significantly less than the right angle. This indicates the hydrophilic properties of all samples’ surface. At the same time, the influence of different geometries of model drawings in printed samples was found not only on the morphology of the samples’ surface according to SEM data, but also on its wettability.
Sectrabank Model to Mitigate Computer Fraud in Electronic Operations through Banking Applications on Android Devices
Authors: Melendez Jhon , Noriega Jomark , Tiznado Jose , Calderon Paulo , Benites Yordy , Rivera Luis , Herrera Jose , Mayhuasca Jorge
Published: April 2024

This research aims to introduce a model, SectraBank, designed to mitigate cyber fraud attacks, specifically targeting SIM Swapping and Fake App schemes in mobile banking users. A quantitative methodology with an experimental design was meticulously employed to examine the rise of cyber fraud within mobile banking. The study involved a sample of 100 professionals with advanced knowledge in Information and Communication Technologies (ICTs). Surveys were utilized to measure awareness of threats and perceptions of security before and after the implementation of the proposed model. SectraBank leverages unique user identifiers such as fingerprint authentication and the International Mobile Equipment Identity (IMEI) number, in addition to geolocation and One Time Passwords (OTP) for validating electronic transactions in mobile banking. The effectiveness of the proposed model was notable, achieving a 96.1% efficacy rate in mitigating Fake App attacks and a 90.2% success rate in countering SIM Swapping attacks. These findings underscore the potential of SectraBank as a robust solution to enhance cybersecurity measures in the realm of mobile banking.
Phase transition thermodynamics of 1,3,5-tris-(α-naphthyl)benzene: theory and experiment
Authors: Yagofarov Mikhail I. , Bolmatenkov Dmitrii N. , Notfullin Airat A. , Sokolov Andrey A. , Balakhontsev Ilya S. , Mukhametzyanov Timur A. , Solomonov Boris N.
Published: April 2024

1,3,5-Tris-(α-naphthyl)benzene is an organic non-electrolyte with notable stability of an amorphous phase. Its glassy and supercooled liquid states were previously studied by spectroscopic and calorimetric methods. However, the thermodynamic parameters of phase transitions available from the literature are inconsistent. In this work, the heat capacities of crystalline and liquid phases, the temperature dependence of the saturated vapor pressures, fusion and vaporization enthalpies were determined using differential and fast scanning calorimetry and verified using the estimates based on solution calorimetry. The structural features of 1,3,5-tris-(α-naphthyl)benzene are discussed based on the computations performed and the data on the molecular refractivity. The consistency between the values obtained by independent techniques was demonstrated. The deviations in the previously published data were attributed to possible polymorphism.
Environmental Law Reform Needed to Manage Trade of Australia’s Threatened Marine Species
Authors: Dominguez-Martinez Rosa Mar , Roberson Leslie , Gephart Jessica , Wilcox Chris , Sant Glenn , Klein Carissa
Published: April 2024

The protection and regulation of international trade of Australia’s native species is legislated by its Environment Protection and Biodiversity Conservation Act of 1999. In response to overwhelming evidence that the Act is ineffective at protecting biodiversity, the Australian Government is currently reforming its environmental laws. One problematic component of the Act is in cases where threatened species interact with multiple regulatory and management frameworks, such as commercially fished marine species that are traded as seafood. Here, we analyzed international seafood trade data and found that Australia exports four threatened fish species listed under the Act and additional species acknowledged as globally threatened. In light of our analysis, we have three recommendations for Australia’s new environmental legislation: 1) apply the same precautions to commercially harvested species as to other threatened species; 2) review the status of all threatened species annually; and 3) assess species listed on global conservation conventions. These recommendations will help ensure that Australia’s marine biodiversity is protected, despite its commercial value.
The Utility of the IWGDF Diabetes-Related Foot Ulcer Risk Classification Annual Reassessment in the Primary Care Setting – a Cohort Study
Authors: Monteiro-Soares Matilde , Dores José , Alves Palma Cristina , Galrito Susana , Ferreira-Santos Daniela
Published: April 2024

Background: We assessed the pertinence of yearly updating the International Working Group on the Diabetic Foot (IWGDF) risk classification in people with diabetes by quantifying the changes in the risk group and its accuracy in identifying those developing an ulcer (DFU) in a primary care setting.
Methods: In our retrospective cohort study, we included all people with diabetes with a foot as-sessment registry between January 2016 and December 2018 in the Baixo Alentejo Local Health Unit. Foot-related data was collected at baseline after one and two years. DFU and/or death until December 2019 were registered. The proportion of people changing their risk status each year was calculated. Accuracy measures of the IWGDF classification to predict DFU occurrence at one, two, and three years were calculated.
Results: A total of 2097 people were followed for three years, during which 0.1% died, and 12.4% developed a DFU. After two years, 3.6% of the participants had progressed to a higher-risk group. The IWGDF classification presented specificity values superior to 90% and negative predictive values superior to 99%.
Conclusion: Foot risk status can be safely updated every two years instead of yearly. The IWGDF classification can accurately identify those not at risk of DFU.
A Framework Using Applied Process Analysis Methods to Assess Water Security in the Vu Gia – Thu Bon River Basin, Vietnam
Authors: Dang Nguyen Mai , Vien Le Ngoc , Tanim Ahad Hasan , Gagnon Alexandre S. , Nguyen Phong Thanh , Tran Duong Anh
Published: April 2024

The Vu Gia - Thu Bon River Basin (VG-TB) is confronting numerous challenges related to water security (WS), particularly in the face of the impacts of climate change. These challenges manifest in salinity intrusion, altered rainfall patterns, and reduced water supply in downstream areas. To assess the current state of water security in the basin, the study employed statistical analysis methods, Process Analysis Method (PAM), SMART, and Analytic Hierarchy Process (AHP) to develop a comprehensive Assessment Framework for Water Security (AFWS) in the VG-TB. The AFWS encompasses five key dimensions, 17 indicators, and 28 variables, aligning with the UN-Water definition of water security and addressing the Sustainable Development Goal 6 (SDG6) criteria for global water sustainability. It also adheres to the Asian Development Bank's (ADB) approach to water security assessment as outlined in the Asian Water Development Outlook (AWDO) reports. This allows for the computation of a comprehensive Water Security Index (WSI) for specific regions, serving as a foundation for decision-making and policy formulation aimed at enhancing water security in the context of climate change and facilitating sustainable basin development in the future.
Dietary Intake and Oral Glucose Tolerance Test Results in Women with Gestational Diabetes
Authors: das Chagas Lucas Almeida , Torloni Maria Regina , Silva-Neto Luiz Gonzaga Ribeiro , Dualib Patricia Medici , de Sousa Rosângela Maria Lopes , Bittencourt Jalila Andréa Sampaio , Araujo Júnior Edward , Granese Roberta , Mattar Rosiane
Published: April 2024

Background: Diet is a risk factor for gestational diabetes mellitus (GDM). There are few studies on women´s diet and glucose tolerance test (GTT) results.
Objective: To evaluate the relationship between previous diet and the number of abnormal values on the diagnostic GTT in women with GDM. We hypothesized there would be an inverse relation between antioxidant micronutrient consumption and the number of abnormal GTT values.
Methods: This cross-sectional study included 60 women diagnosed with GDM (2-hours, 75g-GTT). Shortly after diagnosis, participants answered a validated food frequency questionnaire to assess food consumption in the last 6 months. Mann-Whitney´s test was used to compare the dietary intake of participants with one (group 1) versus two-three (group 2) abnormal GTT values.
Results: Participant characteristics were similar. There were no significant differences between groups in median intake of total calories, carbohydrates, lipids and proteins. Participants in group 1 had significantly higher intakes of fiber (11.9 vs. 11.0 g/day p= 0.049), vitamin D (40.6 vs. 40.4 mcg/day p= 0.049) and vitamin C (180.0 vs. 151.0 mg/day p= 0.008) than those in group 2.
Conclusion: Results suggest a possible association between consumption of fiber and some antioxidant micronutrients and GDM severity at the time of diagnosis.
Pre-pandemic Predictivity of Anxious-Depressive Symptoms in Post-surgical Traumatic Distress in Hysterectomy for Benign Disease and COVID-19 Outbreak: A Case-Control Study
Authors: Ielmini Marta , Casarin Jvan , Callegari Camilla , Bellini Alessandro , Favata Manuela Giada , Giudici Anna , Ghezzi Fabio , Cromi Antonella , Caselli Ivano
Published: April 2024

The Sars-Cov-2 pandemic led to several needed containing measures that conditioned the onset of depressive, anxiety and post-traumatic stress symptoms in population. These symptoms, espe-cially if not diagnosed and treated, can also occur in patients undergoing surgery with high im-pact on people’s lives, like hysterectomy. To evaluate the post-surgical distress and anx-ious-depressive symptoms following hysterectomy for benign disease focusing on the impact of COVID-19 pandemic. The prospective observational cohort study included patients undergoing hysterectomy for benign disease. Psychologic evaluation through social-demographic question-naires was obtained before surgery (T1), postoperatively (T2), and 3 months after surgery (T3). The HADS (Hospital Anxiety and Depression Scale) was used to evaluate anxious-depressive symptoms and the PCL-5 (Post-traumatic Stress Disorder Checklist for DSM-5) compared the on-set of post-surgical distress and anxiety and depressive symptoms. The pre-COVID-19 pan-demic period was compared to the post-COVID-19 pandemic phase. Patients treated after COVID-19 pandemic showed higher depressive symptoms rate compared to those treated before (p-value=0.02); conversely, pre-COVID-19 patients were more prone to develop a PTSD (p-value=0.04). A significative association between the occurrence PTSD and anxiety-depressive symptoms registered at T2 a (p-value=0.007) and T3 (p-value
A Novel Microfluidics Droplet-Based Interdigitated Ring-Shaped Electrode Sensor for Lab-on-a-Chip Applications
Authors: Moraes da Silva Junior Salomao , Bento Ribeiro Luiz Eduardo , Fruett Fabiano , Stiens Johan , Willibrordus Swart Jacobus , Moshkalev Stanislav
Published: April 2024

Droplet-based microfluidics has revolutionized numerous fields such as biomedical research, pharmaceuticals, drug discovery, food engineering, flow chemistry, and cosmetics. This paper presents a comprehensive study focusing on the detection and characterization of droplets with volumes in the nanoliter range. Leveraging the precise control of minute liquid volumes, we introduced a novel spectroscopic On-Chip microsensor equipped with integrated microfluidic channels for droplet generation, characterization, and sensing, simultaneously. The microsensor, designed with Interdigitated-Ring-Shaped Electrodes (IRSE) and seamlessly integrated with microfluidic channels, offers enhanced capacitance and impedance signal amplitudes, reproducibility, and reliability in droplet analysis. We were able to make analyses of droplets length in the range 1.0-6.0 mm, velocity 0.66-2.51 mm/s, droplet volume 1.07nL-113.46nL. Experimental results demonstrated that the microsensor's has a great performance in terms of droplet size, velocity, and length, with a significant signal amplitude of capacitance and impedance, and real-time detection capabilities, thereby highlighting its potential for facilitating microcapsule reactions and enabling on-site real-time detection for chemical and biosensor analyses on-chip.
The Effect of a Cognitive Dual Task on Gait Parameters among Healthy Young Adults with Good and Poor Sleep Quality: A Cross-Sectional Analysis
Authors: Dalbah Jood , Zadeh Shima A. Mohammad , Kim Meeyoung
Published: April 2024

Sleep quality is known to affect automatic and executive brain functions such as gait control and cognitive processing. This study aimed to assess the effect of dual tasks on gait spatiotemporal parameters among young adults with good and poor sleep quality in the United Arab Emirates. In total, 65 young adults with a mean age of 21.1±2.5 were assessed for gait analysis during single-task and dual-task conditions. The participants’ sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and gait was assessed using the BTS Gaitlab System. The participants were asked to walk at natural speed as a single-task condition, followed by walking while performing a cognitive task as a dual-task condition. The parameters assessed included the gait velocity (m/s), cadence (steps/min), step width (m), and stride length (m). The DTC on each gait parameter was calculated. The Mann–Whitney U test was used to compare the differences in the DTC on gait variables between the good and poor sleep quality groups, and the Spearman correlation test was used to assess the correlation between total PSQI scores and the DTC. At a significance level of p<0.05, a significant difference in cadence between the two sleep quality groups was observed, in addition to a positive correlation between sleep quality and the DTC effect on gait mean velocity, cadence, and stride length. Our findings also revealed a greater DTC on participants with poorer sleep quality. These findings contribute to our understanding of the significance of sleep quality in gait performance while multitasking in younger populations.
Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantation in Patients with ALS by Investigating Patient's Specific MicroRNAs as Novel Biomarkers: A Retrospective Study
Authors: Alkhazaali Zahraa , Sahab-Negah Sajad , Boroumand Amir Reza , Farkhad Najmeh Kaffash , Khodadoust Mohammad Ali , Ganjali Rashin , Tavakol-Afshari Jalil
Published: April 2024

Background: Since there is no cure for amyotrophic lateral sclerosis (ALS) currently, it is very important for searching diagnostic biomarkers and novel treatments to reduce the severity of this disease; one of these treatment approaches is stem cell transplantation. This study aims to evaluate the safety and efficacy of repeated transplantation of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) in patients with ALS by analyzing molecular data. Methods: In this single-centre, open-label, phase II clinical trial, retrospective study, fifteen confirmed ALS patients entered the study based on defined inclusion and exclusion criteria and underwent repeated stem cell transplantation (3 times BM-MSCs transplantation (1×10^6) , MSC/Kg BW per injection) concurrently intrathecally (IT) and intravenously (IV), with one-month interval). Clinical assessment of molecular investigation by evaluating specific microRNAs expression (Mir206, 133a-3p, 338-3p) in the patient's serum and Cerebra spinal fluid (CSF) samples were done three times during the 3-month follow-up. Statistical analysis includes paired T-test or Wilcoxon signed ranks. Results: No serious adverse effects were reported following stem cell transplantation. Besides, the mentioned microRNA expression slightly increased but still non-significant (P>0.05). Conclusions: Although Our study demonstrated non-signifying results. However, the still increasing of these MircRNAs in serum and CSF overall, can indicate that repeated transplantation of BM-MSCs was a safe procedure in ALS patients, leading to delay in disease progression and improvement in clinical symptoms. Future studies are needed to confirm these results.
Quality of life of colorectal cancer survivors: Mapping the key indicators by expert consensus and measures for their assessment
Authors: Smrke Urška , Abalde-Cela Sara , Loly Catherine , Calbimonte Jean-Paul , R. Pires Liliana , Lin Simon , Sánchez Alberto , Tement Sara , Mlakar Izidor
Published: April 2024

Quality of life (QoL) assessments are integral to cancer care, yet their effectiveness in providing essential information for supporting survivors varies. This study aimed to elucidate key indicators of QoL among colorectal cancer survivors from the perspective of healthcare professionals, and to evaluate existing QoL questionnaires in relation to these indicators. Two studies were conducted: a Delphi study to identify key QoL indicators and a scoping review of questionnaires suitable for colorectal cancer survivors. Fifty-four healthcare professionals participated in the Delphi study's first round, with 25 in the second. The study identified two primary QoL domains (Physical and Psychological) and 17 subdomains deemed most critical. Additionally, a review of 12 questionnaires revealed two instruments assessing the most important general domains. Findings underscored a misalignment between existing assessment tools and healthcare professionals' clinical priorities in working with colorectal cancer survivors. To enhance support for survivors' QoL, efforts are needed to develop instruments that better align with the demands of routine QoL assessment in clinical practice.
The Aftermath of COVID-19: Exploring Long-Term Effects on the Organ Systems
Authors: Golzardi Maryam , Hromić-Jahjefendić Altijana , Šutković Jasmin , Aydin Orkun , Aydin Pinar , Bećirević Tea , Redwan Elrashy M. , Rubio-Casillas Alberto , Uversky Vladimir N.
Published: April 2024

Background: Post-acute sequelae of SARS-CoV-2 infection (PASC) is a complicated disease that affects millions of people all over the world. Previous studies have shown that PASC impacts 10% of SARS-CoV-2 infected patients of which 50-70% are hospitalized. It has also been shown that 10-12% of those vaccinated against COVID-19 were affected with PASC and its complications. The severity and the later development of PASC symptoms is positively associated with the early intensity of the infection. Results: The generated health complications caused by PASC involve a vast variety of organ systems. Patients affected by PASC have been diagnosed with neuropsychiatric and neurological symptoms. Cardiovascular system also has been involved and several diseases such as myocarditis, pericarditis, and coronary artery diseases were reported. Chronic hematological problems such as thrombotic endothelialitis and hypercoagulability were described as a condition that could increase the risk of clotting disorders and coagulopathy in PASC patients. Chest pain, breathlessness, and cough in PASC patients were associated with respiratory system in long COVID-19 causing respiratory distress syndrome. The observed immune complications were notable, involving several diseases. Renal system also was impacted and result in raising the risk of diseases such as thrombotic issues, fibrosis, and sepsis. Endocrine gland malfunction can lead to diabetes, thyroiditis, and male infertility. Symptoms such as diarrhea, nausea, loss of appetite and taste were also among reported observations due to several gastrointestinal disorders. Skin abnormalities might be an indication of infection and long-term implications such as persistent cutaneous complaints were linked to PASC. Conclusions: Long COVID is a multidimensional syndrome with considerable public health implications, affecting several physiological systems and demanding thorough medical therapy as well as more study to address its underlying causes and long-term effects.