bluuebunny/crossref_metadata_2025 huggingface dataset:
Comunidades de aprendizagem profissional: a avaliação como suporte da ação: a avaliação como suporte da ação
Authors: De Oliveira Michel Franklin , Ferreira Sandra Lúcia , Dalmacir da Silveira Luiz
Published: January 2024

Este estudo propõe o Sistema de Acompanhamento de Dados Educacionais (SADE) para aprimorar a gestão das Escolas Técnicas (Etecs) de São Paulo, transformando dados de avaliação classificatória em insights para a avaliação formativa. O SADE visa facilitar a tomada de decisões informadas, processando informações do questionário socioeconômico e do Resultado do Processo Seletivo – Vestibulinho com softwares como Microsoft Excel, Power BI e Iteman. Com o Power BI, grandes volumes de dados são convertidos em dashboards interativos, otimizando a análise e visualização de dados, o sistema destaca a importância da reflexão contínua nas práticas de gestão educacional e a colaboração Comunidades de Aprendizagem Profissional (CAPs) como um suporte para gestores, professores e políticas públicas para o sucesso de sua implementação.
Taller de arquitectura como umbral
Authors: Sánchez Toro José Antonio , Chong Vega Reinaldo , Antezana Saavedra Matías , Guzmán Adolfo
Published: January 2024

El diccionario de la RAE define Umbral como el “paso primero y principal o entrada de cualquier cosa”, mientras que su etimología, que nos remite al latín liminaris (o liminar) nos da cuenta de la importancia de transicionar, experimentar y asimilar este concepto como posibilidad y oportunidad transformadora. Es así como el Taller Integrado Umbral existe como una instancia complementaria al ciclo inicial que los estudiantes deben cursar al ingresar al primer año de la carrera de arquitectura en la Escuela de Arquitectura de la Universidad de Valparaíso. Busca dar continuidad a quienes por distintas circunstancias no han logrado aprobar algunos de los dos talleres que componen este nivel.El taller se desarrolla desde cinco perspectivas: 1. Hallazgo y preexistencia, 2. El relato como herramienta para pensar una arquitectura. 3. Componer y ensamblar el material 4. El Dibujo como experimentación y precisión. 5. El tiempo o los tiempos de aprendizaje: del encargo personal a la experiencia workshop colectivo. El trabajo realizado al interior del taller se aborda desde lo colectivo, en equipos de estudiantes acompañados por los profesores.
Dibujar la música y pintar la poesía
Authors: Peragallo Del Solar Roberto , Larraín Salinas María Soledad
Published: January 2024

El presente artículo se centra en la importancia didáctica del uso conceptual de referencias y técnicas artísticas en la enseñanza de la arquitectura. El objetivo principal es explorar cómo el arte puede servir como una herramienta efectiva para enriquecer el proceso de aprendizaje en el campo arquitectónico, a través de un caso de estudio específico: el Taller de Arquitectura II, llevado a cabo en la Universidad del Desarrollo durante los años 2017-2018, bajo la tutela de los docentes arquitectos Roberto Peragallo, Soledad Larraín y las ayudantes Alejandra Martí y Andrea Coxhead.
La metodología propuesta se basa en la integración de disciplinas artísticas, como la pintura, la música, la poesía y el cine, como soporte para el aprendizaje arquitectónico. Se examina cómo la utilización de estas puede estimular la creatividad, fomentar la observación detallada, promover la sensibilidad espacial y fortalecer el sentido humanista en los estudiantes de arquitectura. Además, se analiza el papel de las referencias artísticas como una fuente de inspiración para la conceptualización, proceso y materialización de proyectos arquitectónicos.
El estudio de caso detalla las actividades realizadas en el marco del taller, donde los estudiantes fueron desafiados a traducir elementos musicales, poéticos y pictóricos en formas, espacios y volúmenes pre-arquitectónicos. Para ello se describen las técnicas utilizadas para capturar las cualidades intangibles de las artes en el lenguaje arquitectónico, así como la experimentación como método de investigación creativa.
Los resultados preliminares revelan que la integración de las artes en la enseñanza de la arquitectura puede enriquecer la experiencia educativa, fomentar la originalidad y fortalecer las habilidades perceptivas, proyectuales y hábitos humanistas de los estudiantes. Este artículo busca destacar la relevancia de la implementación de estas metodologías en la formación de futuros arquitectos y arquitectas, así como promover un enfoque multidisciplinario en la enseñanza de la arquitectura.
Nada es tan así
Authors: Subercaseaux Medina Pía
Published: January 2024

Pinturas de Pía Subercaseaux Medina. Exposición del Instituto Cultural de Las Condes. Fecha: 5-30 de mayo, 2022
Fundação Dom Aguirre
Authors: Vannucchi Aldo
Published: January 2024

Como único sobrevivente dos instituidores da Fundação Dom Aguirre, criada em 23 de novembro de 1963, atrevo-me a contar nestas páginas, com certa ousadia e incontida satisfação, os 60 anos dessa benemérita entidade sorocabana.
Faço-o consciente dos meus 64 anos de trabalho dentro dela, como professor e diretor da sua Faculdade de Filosofia, Ciências e Letras, idealizador do seu Colégio Dom Aguirre e primeiro reitor da sua Universidade.
De tão patente simbiose, ganhei conhecimentos e experiências, apoiado na granítica e fecunda perenidade dessa alma mater de todos nós.
Aqui ficarão registrados os nomes principais e os momentos marcantes de uma história sexagenária, ancorada na robustez de uma ideia e na persistência de um ideal, evidentes no perfil jurídico de uma Fundação com traços exuberantes de mãe e mestra, na seara da educação, em Sorocaba.
Que a leitura destas páginas inspire reconhecimento e gratidão profunda a todos os que participaram da construção e do desenvolvimento desse monumento vivo e vivificante, nessas seis décadas de caminhada, e estimulem quantos, hoje, vivem à luz benfazeja dessa querida Fundação.
Experiências com pesquisas em comunicação
Authors: Ogécia Drigo Maria , Martinez Monica
Published: January 2024

Primeiro livro produzido pelos docentes do Programa de Pós-Graduação em Comunicação e Cultura da Universidade de Sorocaba (Uniso), com foco nas metodologias que utilizam em suas pesquisas, tanto as que desenvolvem como as que orientam. Os docentes oferecem nos capítulos, a ideia de que o programa não busca uma fundamentação teórica a ser perseguida por todas os pesquisadores, mas propõe que cada objeto de estudo deve se impor como tal e com ele buscarmos diferentes metodologias e perspectivas teóricas. Esperamos, de um lado, que a socialização dessas experiências traga contribuições para a compreensão do “fazer científico” na área; de outro, que se constitua num exercício de aprendizagem, por parte dos docentes, à medida que estes se submetem ao olhar do outro. Este livro é o primeiro de uma série que pretendemos publicar, sendo que os demais envolverão mestrandos e doutorandos do Programa, em parceria com seus orientadores, bem como pesquisadores de outros programas de pós-graduação, tanto nacionais como internacionais.
Explorando o universo viral dos predadores bacterianos
Authors: Balcão Victor Manuel Cardoso F. , Duarte Carvalho Vila Marta Maria
Published: January 2024

A fagoterapia, ou terapia bacteriofágica, tem ressurgido como uma alternativa para o combate de infeções bacterianas. As perspectivas são promissoras quanto ao uso de bacteriófagos (ou fagos) para o combate de doenças infecciosas em humanos, animais e espécies vegetais, bem como para o controle de contaminação ambiental por patógenos bacterianos. No entanto, muito ainda há a fazer para a comprovação da sua eficácia e segurança. Nesta perspectiva, almejou-se, com este manual, contribuir para a viabilização de resultados confiáveis e promissores visando aplicações futuras de fagos na medicina humana e veterinária, meio ambiente, agricultura e indústria alimentícia. A obra aqui apresentada foi motivada pela necessidade de padronização de protocolos e técnicas para a manipulação de fagos isolados/utilizados no Laboratório de Vírus Bacterianos (VBlab) da Universidade de Sorocaba (Uniso) desde 2015. A ordenação dos protocolos objetivou uma sequência lógica para o isolamento, purificação, propagação e caracterização dos fagos isolados. Os procedimentos são simples e, em cada um, são apresentados, além do ensaio em si, todos os reagentes e materiais necessários para sua execução, além de um conjunto de explicações de determinadas etapas (os “bioporquês”).Este manual prático destina-se a estudantes e pesquisadores que se dedicam ao estudo dos bacteriófagos e suas possíveis aplicações num contexto de aumento generalizado das resistências bacterianas aos antibióticos.
Data Science and Its Importance
Authors: Galkaduwa Chethiya , Ranasinghe Nethimini
Published: January 2024

Data science is an interdisciplinary subject that uses scientific methodologies, data mining techniques, machine-learning algorithms, and large amounts of data to extract information and insights. The article presents an overview of the current state and future possibilities of Data Science in a variety of sectors, explores the benefits, outlines the frameworks and methodologies employed, explains the current obstacles, and offers feasible solutions.
Countertransference inside and outside sessions: the impact of Countertransference on the therapist’s post-session elaboration
Authors: Bei Francesco De , Negri Attà , Dell’Arciprete Gaia , Rocco Diego
Published: January 2024

Objective: Countertransference (CT) research has demonstrated
the importance of CT management for successful therapy outcomes. Over
time, CT research began to take this aspect more and more seriously and
expanded the concept of CT management to include aspects, such as stable
characteristics of the therapist and his or her theoretical model, that
do not necessarily pertain the single session (e.g., therapist’s
self-integration, theoretical framework). In this study we further
expand the boundaries of CT management by investigating the relationship
between CT experienced within sessions and the elaborative activity
taking place between sessions. Method: Twenty-three in-training
psychotherapists were asked to rate their emotional reactions through
the Therapist Response Questionnaire at the end of 69 counselling
sessions and to fill the Post Session Therapist Questionnaire, an
instrument assessing three relevant reflexivity activities in the
post-session time. The 69 sessions were also recorded, transcribed and
evaluated by three external raters, who applied the Countertransference
Behavior Measure. Results: Results showed significant
correlations between some dimensions of CT experienced in the session
and some dimensions of the therapist’ post-session working through.
Conclusion: Results highlighted the centrality of the
reflexivity processes that therapists put in place between sessions and
not only within the session to increase awareness of their
countertransference, a prerequisite for its handling during the session
for therapeutic purposes.
Neuromarketing Practices and Their Role in Raising the Efficiency of Marketing Performance -
Authors: Abdul Ghafoor Qutiba Amjad , Al Khazraj Mohammed Edan Bani
Published: January 2024

This research aims to diagnose the impact and contribution of Neuromarketing on the marketing performance of Sardar Automotive Trading Company and determine the nature of that relationship. To achieve this, the research seeks to understand the role played by Neuromarketing in enhancing overall marketing performance. Sardar Automotive Trading Company, a public company specializing in car and machinery trading, was chosen as the research site. A total of (58) questionnaires were analyzed, and distributed among a sample of marketing department managers and employees within the company, serving as the research sample. The data was analyzed using the statistical software SPSS, and a descriptive-analytical approach was adopted in conducting the research. The results indicated a significant relationship and correlation between neuromarketing and marketing performance. The research recommends that decision-makers within the company focus on marketing strategies based on the philosophy of Neuromarketing to influence customers, thereby achieving higher sales and greater profits, ultimately improving the entire marketing process
The Propensity for Dating Apps Usage and the Millennials’ Interpersonal Skills Development
Authors: Rosean Lorena , Matić Jennifer , Samardžija Jasminka
Published: January 2024

The research examines the relationship between personality types and the inclination to use dating apps in the context of establishing long-term relationships. Specifically, it quantitatively tests whether there is a correlation between millennials’ preference for dating apps and their readiness for real-life interactions. The main hypothesis posits that introverted millennials exhibit a more pronounced tendency to use dating apps. To test this, an anonymous online survey was conducted using Google Forms, with Facebook as the research platform. The study aimed to gain a comprehensive psychological profile of dating app users and their dating habits. The research focused on millennials in Croatia (born between 1987 and 1994) residing in Zagreb. The independent variable was the development of millennials’ interpersonal skills, while the dependent variable was defined as the inclination to use dating apps. The primary hypothesis, asserting that introverted millennials have a heightened propensity for using dating apps, was not fully confirmed. Instead, the study reveals a stronger inclination among introverts to use dating apps and messaging as communication tools for social interactions, not necessarily for longterm relationships. Our results are in line with Social Exchange Theory. In the context of the data, individuals seem to make choices regarding digital communication platforms based on the perceived benefits, such as mitigating the emotional impact of rejection, convenience, and the enjoyment derived from these interactions. The theory also touches upon the concept of rewards and costs, where individuals seek relationships or interactions that provide more rewards than costs. In this case, the rewards may include emotional comfort, convenience, and enjoyment, while the costs might involve potential face-to-face discomfort or rejection.
Innovative application of inulin-gel suspension in poultry sausages: Technological impact and nutritional enhancement
Authors: Petricevic Maja , Stamenic Tamara , Keskic Tanja , Stanisic Nikola , Stanojkovic Aleksandar , Delic Nikola , Petricevic Veselin
Published: January 2024

Consumer demand for healthier foods has led the industry to look for
alternatives to reduce high-fat levels. Dietary fibers such as inulin have
emerged as promising substitutes for fat, increasing nutritional value and
reducing fat absorption. The aim of this research was to formulate chicken
cooked sausages in which the fat was replaced by inulin suspension at
different levels. Four groups of sausages participated in the experiment:
group K without fat replacement and groups 50%IN, 75%IN, and 100%IN with
50%, 75%, and 100% fat replacement, respectively. The results show a
significantly higher process and cooking loss in the experimental groups
compared to group K (p<0.05). Groups K and 50%IN had significantly better
emulsion stability (p<0.05). Increasing inulin content significantly
affected color characteristics, including L* (lightness), a* (redness), and
b* (yellowness) (p<0.05). The experimental groups of sausages had a lighter
color. By reducing fat, the caloric value of sausages decreased
significantly and differed between groups (p<0.01). Inulin can be used to
produce cooked sausages with reduced fat content and optimal physical and
chemical properties. In addition to the reduced energy value, this meat
product also has good nutritional characteristics.
Social participation, resilience, and coping tendency in a sample of stroke survivors: a multi-centre cross-sectional study in China
Authors: Zhou Xuan , Wang Ying , Zhou Lanshu
Published: January 2024

Objectives: To investigate the association between resilience and social participation and examine the mediation of resilience on coping strategies and social participation.
Design: A multi-centre cross-sectional study performed from April to July 2022.
Participants: The study sample comprised 239 stroke survivors (53.1% male). The mean age of participants was 65.4 years.
Methods: The study was conducted at 3 neurorehabilitation centres in Shanghai, China. The Utrecht Scale for Evaluation of Rehabilitation Participation (USER-P) was used to measure both objective and subjective social participation. Resilience was evaluated using the Connor-Davidson Resilience Scale (CD-RISC), while positive coping tendency was assessed using the Simplified Coping Style Questionnaire (SCSQ). Multivariate linear regression was employed, taking into account confounding factors. In cases where a significant interaction effect was observed, simple slope analysis was conducted to explore the relationship between positive coping tendency and social participation at different levels of resilience.
Results: The mean scores of social participation frequency, restriction, and satisfaction were 21.80 ± 15.13, 38.92 ±  26.48, and 63.34  ± 22.35, respectively. Higher resilience level was independently associated with higher social participation frequency (B = 0.210, p < 0.001), less participation restriction (B = 0.584, p < 0.001), and higher participation satisfaction (B = 0.250, p < 0.001). Moreover, higher resilience was correlated with more positive coping tendency. More positive coping tendency was related to higher social participation frequency and less participation restriction, but not to social participation satisfaction. Furthermore, individuals at different resilience levels moderated the effect of positive coping tendency on social participation frequency.
Conclusion: This study underlines the importance of resilience as a potential intervention in enhancing both objective and subjective social participation in stroke survivors, and provides insights into increasing the efficacy of positive coping strategies on social participation.
Review on ChatGPT: History, Applications and Limitations in Chemistry
Authors: Etim EE
Published: January 2024

The advancement in Artificial intelligence has ushered new opportunities in various aspects of life and fields of study. Among the various AI tools developed, chatGPT has gained considerable attention due to its natural language model and interactive capabilities. It has been recognized as a powerful tool for various applications in chemistry such as physical, organic, inorganic, analytical, industrial, environmental, polymer and food chemistry etc. in this review, we focused on the applications of chatGPT in the above named fields of chemistry. We discussed the evolution of chatGPT from the original GPT model to the current chatGPT model and we also examine the limitations of chatGPT. This review provides a comprehensive summary of the history, potential applications and limitations of chatGPT in the field of chemistry, along with in-depth insight on the future prospect of the technology.
Environmental Trace Metal Concentrations in the Okrika Stretch: A Comprehensive Study on Pollution Indicators
Authors: U Nweke-Maraizu
Published: January 2024

The Okrika Stretch of Bonny River, Nigeria, has long been a vital ecological and economic resource for the surrounding communities. However, increasing industrialization and anthropogenic activities have raised concerns about the potential pollution of this precious aquatic ecosystem. This study delves into the assessment of environmental trace metal concentrations, specifically Lead (Pb), Nickel (Ni), Zinc (Zn), Copper (Cu), and Iron (Fe), as pollution indicators in various components of the Okrika Stretch. The research scrutinizes water, sediment, oyster, and periwinkle samples, utilizing cutting-edge analytical techniques to measure trace metal levels. Sampling was carried out at five distinct locations, including a control site situated outside the presumed affected area, for both dry and wet seasons throughout the year. Following collection, the samples of water, sediment, oyster, and periwinkle underwent digestion and subsequent analysis using the Bulk Scientific Model 200A Atomic Absorption Spectrophotometer (AAS). Our findings reveal a complex interplay of trace metal concentrations across different environmental components. The water samples exhibit varying levels of these metals, reflecting the dynamic nature of riverine systems. Sediment analysis identifies hotspots of metal accumulation, potentially posing risks to aquatic life. Oysters and periwinkles, as vital components of the food web, accumulate trace metals at different rates, providing insights into potential human health implications. This research not only sheds light on the current state of pollution within the Okrika Stretch but also underscores the importance of continued monitoring and mitigation efforts. The results call for a comprehensive environmental management strategy to safeguard the ecological and economic sustainability of the Bonny River region. By addressing the complexities of trace metal pollution, this study contributes to the broader discourse on safeguarding our invaluable aquatic ecosystems worldwide.
Innovation of Multimodal Digital Modules Based on Ethnomathematical Problems for Meaningful Mathematics Learning in Merdeka Curriculum
Authors: Suryawan I Putu Pasek , Lasmawan I Wayan , Suharta I Gusti Putu
Published: January 2024

The essence of the curriculum Merdeka expects mathematics learning to be meaningful and in accordance with learning styles and needs.  Culture and technology are the right combination to be applied in mathematics learning to implement the curriculum Merdeka.  This research aims to develop multimodal digital modules based on ethno mathematical problems for meaningful mathematics learning that can adapt to technological developments. The development model used in this study is the ADDIE model. The service of the module is determined by the results of expert validation, practicality tests, and effectiveness tests by lecturers, teachers and students as research subjects. Based on the material validity test, a validity of 4.45 was obtained and a media validity test obtained a validity of 4.87 which was included in the Very High category. The average practicality score is 4.3 with very high criteria.  The range of grades obtained by students is 83%. Thus the modules developed can be said to be effective and feasible to use. Through the innovation of this module, learning becomes meaningful, accommodates every learning style and student need, and facilitates students to learn independently.
From Variables to Research Design: A Deep Dive into Educational Research Methodology
Authors: Adeoye Moses Adeleke
Published: January 2024

The systematic collection and analysis of data relevant to the field of education are referred to as educational research. Research writing is a laborious practice that methodically approaches the solution to a given research challenge. It differs from educational institutions and is typically led by a format. This study aims to analyze methodological explanation of variables, background to the study, literature review & research design as ways of promoting vigorous scholarship. This research uses the Systematic Literature Review (SLR) method. The results of this research explain many types of in-depth research methodology. These resources' main goal is to assist young academics and education professionals in learning about the background of the study, literature review, research design, and methodological explanation of variables. Educational research plays a crucial role in the development and improvement of educational practices and policies. It enables educators and policymakers to make informed decisions based on evidence and data. These offer beneficial fundamental knowledge for those who wish to pursue careers as researchers.
Delweddu Cymru a’r Rhyfel Mawr: Portreadau o Gymru a’r Cymry mewn rhaglenni dogfen am y Rhyfel Byd Cyntaf
Authors:   , Palmer Naomi
Published: January 2024

Dadansodda'r traethawd hwn y ffordd y mae rhaglenni dogfen Cymraeg am y Rhyfel Byd Cyntaf ar gyfer S4C rhwng 1980 ac 2018 wedi portreadu Cymru a phrofiadau'r Cymry o'r cyfnod hwnnw. Un o brif gwestiynau’r ymchwil yw ystyried os oedd gan Gymru stori rhyfel unigryw ei hun, sy’n wahanol i’r naratif Prydeinig o’r rhyfel ac ym mha ffyrdd y cyflwynir y naratif hwnnw. Mae’r straeon hyn am Gymru, am gymunedau, pobl a theuluoedd Cymraeg/Cymreig, a’u profiadau nhw o’r rhyfel.Gellid dadlau y byddai rhai o'r straeon hyn am hanes Cymru a’r Rhyfel Byd Cyntaf yn straeon coll, heb y rhaglenni dogfen. Bydd yr ymchwil yn cymryd i ystyriaeth yr agweddau diwylliannol, ieithyddol, cymdeithasol, economaidd a chrefyddol yng Nghymru, a bod gwahaniaethau yn yr agweddau hyn yn golygu profiadau gwahanoli’r Cymry. Trwy ddadansoddiad manwl o gynnwys 33 o raglenni Cymraeg ar gyfer S4C eir ati i adnabod patrymau yn y pynciau a themâu sy’n ymddangos ynddynt.Canlyniad hyn oedd ffurfio rhestr o’r hyn gellid ei ystyried yn naratif Cymreig y Rhyfel Byd Cyntaf. Dangosa'r rhestr gafodd ei ffurfio bod naratif penodol Gymreig i'r rhaglenni hyn, a mae parodrwydd S4C i barhau i fuddsoddi mewn rhaglenni newydd am y Rhyfel Byd Cyntaf yn dystiolaeth o'r naratif unigryw hwnnw sy'n bodoli ond hefyd bod straeon newydd a safbwyntiau gwahanol i'w hadrodd. Ystyria’r traethawd hefyd y newidiadau o fewn y genre dogfen hanesyddol dros y degawdau, gan ddefnyddio'r rhain i lunio strwythur y penodau gan gynnig ystyriaeth o’r modd y ffurfiwyd naratif Cymreig.
A Randomised Control Trial evaluating The GUIDE Cymru: All Wales mental health literacy in Year 9 children in Wales
Authors:   , Simkiss Nicola
Published: January 2024

Adolescent and young people’s mental health problems are increasingly prevalent within the United Kingdom (UK), and a lack of mental health knowledge can often lead to negative stereotypes of mental illness. This thesis aims to contribute to the expanding field of Mental Health Literacy (MHL) among adolescents and young people. Chapter 1 outlined the prevalence of mental health problems during adolescence and the need for early intervention. Chapter 2 reviews mental health stigma and details the importance of stigma reduction through improving knowledge and MHL. Chapter 3 introduces the development of a new measure of MHL, known as the Knowledge and Attitudes to Mental Health Scale (KAMHS). Chapter 4 investigates associations between mental health and MHL constructs and assesses the importance of MHL as more than just mental health knowledge, extending to the broader construct of help-seeking efficacy, stigma, and coping mechanisms. Chapter 5 outlines a pilot study in the evaluation of the Guide Cymru through a pre and post-test design. Moreover, Chapter 6 illustrates a cluster randomised control trial used to evaluate a The Guide Cymru within secondary schools across Wales. Chapter 7 reviews the research presented throughout the thesis, considering the broader implications of the findings and recommendations for future research. This thesis, therefore, contributes to the field of MHL by demonstrating that providing teachers with appropriate resources and training to deliver the Guide Cymru can significantly improve the MHL of pupils. The findings provide valuable insights into future research supporting child and adolescent mental health.
Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review
Authors: Magfiroh Yani
Published: January 2024

The modern lifestyle despite its comfort has made cancer a second leading public health problem, following cardiovascular disease. As chemotherapeutic has many side effects including resistance, recent attention has focused on plants which may provide a good opportunity for complementary cancer treatment. Several studies have begun to focus on metabolomic research in order to discover the mechanisms of action of diverse medicinal plants, investigate biomarkers, and comprehend cancer progression at metabolic rates. This study aims to analyze and highlight related metabolomic investigations in medicinal plants that demonstrate the potential of biomarker compounds and their processes in cancer disease. The research methodology uses a literature review that is compiled from many connected journals. According to the findings, bioactive substances present in medicinal plants can be used as biomarkers to disrupt the metabolism of enzymes, transporters, and signaling pathways in cancer cells. Utilized analytical platforms include HPLC, GC-MS, FTIR and NMR. Statistical analysis employs the Anova, PCA, and OPLS-DA methods. Finally, we reviewed biomarkers of medicinal plants and metabolomic pathways, with the result that anticancer compounds may exert their activity by various methods affecting DNA replication, cell cycle, migration and apoptosis.
Pemilihan Moda Transportasi Perjalanan Kerja di Desa Karanggeneng Boyolali
Authors: Hidayati Nurul , Prasetyo Guruh Seto , Mulyono Gotot Slamet , Magfirona Alfia
Published: January 2024

Transportasi memegang peranan yang sangat penting karena melibatkan dan mempengaruhi banyak aspek kehidupan manusia termasuk dalam beraktifitas menuju tempat kerja. Penelitian ini bertujuan untuk menggambarkan karakteristik dan faktor-faktor yang mempengaruhi pemilihan moda perjalanan kerja dan menganalisis modelnya. Metode análisis menggunakan model logit biner selisih dan rasio. Data yang digunakan diperoleh dari penyebaran kuesioner ke responden, yaitu warga Desa Karanggeneng Boyolali. Berdasarkan hasil analisis dapat disimpulkan bahwa mayoritas warga yang melakukan perjalanan kerja berjenis kelamin laki-laki (61,5%). Jenis moda yang paling banyak digunakan pengguna adalah sepeda motor (81,5%). Mayoritas warga desa menempuh jarak perjalanan kerja sejauh 3-6 km (25,5%), dan waktu tempuh 5-10 menit (34%). Mayoritas warga yang diteliti mempunyai pendapatan per bulan berkisar antara Rp. 1.000.000 sampai Rp. 2.000.0 (40%). Semakin besar selisih biaya perjalanan menyebabkan semakin besar probabilitas memilih sepeda motor (P1). Meskipun demikian saat kondisi selisih biaya keduanya adalah 0, maka probabilitas pelaku perjalanan memilih motor sebesar 46%. Hal ini menunjukkan bahwa moda mobil lebih diminati dibandingkan sepeda motor pada biaya yang sama. Semakin besar rasio biaya kedua kendaraan di atas, menyebabkan semakin besar peluang memilih Moda 1 (sepeda motor). Saat rasio biaya kedua jenis kendaraan bernilai 1, maka diperoleh probabilitas memilih sepeda motor sebesar 65%.
Innovative Legal Modeling for Interdisciplinary Studies on Law and Economic Behavior
Authors: Isman I , Muttaqin Ahmad Zainul
Published: January 2024

This study introduces a new paradigm for interdisciplinary empirical legal research by presenting a groundbreaking perspective on the integration and interconnectedness of law and economics. Our research argues for the necessity of this shift. The conventional pragmatic paradigm, which risks fragmenting concepts and methods by reducing meaning to mere data and facts, is eschewed in favor of an integrationinterconnection theory. This paper investigates the theoretical foundations of the proposed paradigm through library research and philosophical inquiry. Our research uncovers two distinct approaches within the new empirical legal studies paradigm. Firstly, the historical approach requires a restructuring of the theory, leading to multidimensional and holistic models. Secondly, the philosophyasasystem approach necessitates method restructuring by utilizing cognitive, holistic, open, and purposeful models. The integration aspect of the paradigm necessitates a comprehensive theoretical restructuring, while the interconnection aspect requires a broadened viewpoint. The historical approach is demonstrated by historical reformation, which encompasses multidimensional and holistic models. In contrast, the philosophyasasystem approach entails methodical reforms through the incorporation of models that focus on cognition, wholeness, openness, and purposefulness. The historical and methodical restructuring prototypes can be seen in the Integrative Legal Theory Model and the Critical Legal Functionalism Model. Our study highlights the significance of incorporating economic behavior into the interdisciplinary framework of empirical legal studies. This will enable a more comprehensive understanding of the complex connections between law and economic dynamics.
Combination of Ketepeng Cina (Cassia alata Linn) And Lidah Buaya Buaya (Aloe vera) As Antibacterial Agent Against Staphylococcus aureus And Pseudomonas aeruginosa
Authors: Muflihah Cita Hanif , Husna Az Zahra Miftahul , Hamka Aminah Fitriana
Published: January 2024

Infection is one of the biggest health problems in Indonesia. Infection can be caused by pathogenic microorganisms such as Staphylococcus aureus and Pseudomonas aeruginosa. Treatment with antibiotics is the primary choice to manage infections caused by bacteria. Previous research showed that many plants have been tested for their antibacterial activity such as ketepeng cina (Cassia alata) and lidah buaya (Aloe vera). Cassia alata and Aloe vera alkaloids, flavonoids, anthraquinones, saponins, tannins contain similar active compounds as antimicrobials. Based on this, the purpose of this study was to determine the antibacterial activity of the combination of methanol extracts of C. alata and A. vera against S. aureus and P. aeruginosa bacteria. The antibacterial activity test was carried out using the Kirby-Bauer method. The single extract of C. alata and A. vera had the greatest antibacterial activity against S. aureus at a concentration of 10 mg/disk with zones of inhibition of 29.5±0.7 mm and 21.5±1.4 mm, respectively. The single antibacterial activity test of both extracts against P. aeruginosa bacteria showed no inhibition zone. The test results showed that the combination of 10 mg/disk C. alata methanol extract and 10 mg/disk Aloe vera could inhibit the growth of S. aureus with an average inhibition zone of 30.75±1.7 mm. However, the lower ratio of both extracts resulted in a likely antagonistic effect against S. aureus. Phytochemical screening tests showed that these two extracts had the same compounds, namely phenolics, flavonoids, anthraquinones. Contact bioautography showed that mainly phenolics, flavonoids, and anthraquinones were responsible in the antibacterial properties.
A Bibliometric Analysis of Aloe vera in Wound Healing
Authors: Sari Asti Arum , Rahmawati Reza
Published: January 2024

People have used Aloe vera for a variety of traditional medical applications. A. vera has been proven in numerous studies to play a key function in wound healing. Although there are many reviews on this topic, bibliometric analysis is not found in the literature. This study uses bibliometric analysis to evaluate the influence and relevance of the countries, journals, organizations, and authors that have made the most contributions to this topic. Scopus database was used to gather bibliographic data on relevant studies. A total of 417 published articles between 1981 and 2023 were selected. VOSviewer version 1.6.18 was used to conduct a bibliometric analysis of these papers. On the topic of A. vera as a wound healing agent, Tehran University of Medical Science from Thailand was the most productive institution and Journal of Ethnopharmacology was the most productive journal. India was the most productive and collaborative country. The spotlight of the recent papers was the use of biotechnology techniques and drug-delivery strategies of A. vera in wound healing. Developing formulation using various drug-delivery methods followed by in vivo preclinical and clinical studies of this particular topic were potential to be explored.
The Effect of Pharmacist Counseling on Medication Adherence and Blood Pressure Values in Hypertensive Patients
Authors: Sabiti Farroh Bintang , Fatiha Chilmia Nurul , Timur Willi Wahyu , Dewi Peggy Anastia
Published: January 2024

Hypertension is a disease often found in Indonesia. Hypertension can be controlled by compliance with taking medication and a healthy lifestyle. One effort to increase compliance is counseling. Pharmacist counseling can provide patient education and understanding of hypertension therapy while ensuring that patients are taking medication appropriately so as to increase compliance and control blood pressure. The aim of the research was to determine the effect of pharmacist counseling on drug compliance on blood pressure values in hypertensive patients at the Semarang Community Health Center. This research is a pre-experimental study with a One Group Pretest-Posttest design. Data collection was taken in March-April 2019. Blood pressure results were obtained before and after counseling with a value of p = 0.000 (p 0.05). This research can be concluded that pharmacist counseling can influence medication adherence and systolic and diastolic blood pressure values in hypertensive patients at the Semarang Community Health Center
Virtual Screening to Identification The Active Compounds from Kratom (Mitragyna speciosa) as Analgetics
Authors: Arief Ihsanul , Inderiyani Inderiyani
Published: January 2024

Kratom (Mytragina speciosa) is one of the endemic plants in Southeast Asia in general and Kalimantan in particular which is proven to have activities as an analgesic, sedative (antidepressant), and, antiobesity, breast anticancer, antinociceptive, CYP450 induction, anti-inflammatory, opiate, antimicrobial, and antioxidant. However, no report states the active compounds from kratom leaves that have these activities. Therefore, this study will identify the active compounds contained in kratom leaves with a virtual screening process responsible for analgesic activity along with the prediction of adsorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. The virtual screening process was performed based on molecular tethering, while the prediction of ADMET properties was done with the help of a web server. The results obtained showed that the compound (-)-epicatechin was most responsible for the analgesic activity of kratom leaves. The ADMET profile of this compound predicts that it has good bioavailability and is non-toxic.
Validation of Analytical Method LC MS/MS for Determination Isoniazid in Rats Serum
Authors: Suhendi Andi , Rohman Abdul , Wahyono Djoko , Nurrochmad Arief , Manggo Tasya Faradillah
Published: January 2024

Determination of isoniazid concentration for therapeutic drug monitoring must produce valid values, so validation of the analytical method of LC-MS/MS needs to be carried out. This research aims to obtain valid method of LCMS/MS in order to determination isoniazid in rats serum. Sample preparation was carried out using the liquid-liquid extraction method using acetonitrile and methanol (2:1). The chromatography system was developed with a C18 column (ACQUITY UPLC® HSS T3 1.8 µm, 2.1 × 100 mm), the mobile phase was 70% acetonitrile with 0.1% formic acid (A), water with 0.1% formic acid (B), as well as methanol (C) with a flow rate of 0.3 mL/min, with gradient elution, detection in ESI+ mode with multiple reaction monitoring (MRM) at the transition 138 m/z → 121 m/z. The research results showed that the method was accurate with a % recovery of 96 - 113% and an RSD of 2.4 ± 0.9%. The precision value was obtained with an average RSD of 3.7 ± 2.4% for intra-day and 4.1 ± 2.3% for inter-day. Linearity showed good results with a correlation coefficient of 0.9956 in tests with 5 different concentrations. The LOQ and LOD values obtained from the linear regression equation were 0.1987 µg/mL and 0.0656 µg/mL respectively. The results showed that the LC-M/MS method was valid for determining isoniazid levels in rat serum
Demographic, Clinical, and Antiretroviral Regiment Treatment Characteristics of HIV/AIDS Patients at the Regional General Hospital of Central Papua
Authors: Mar’ah Siti Sitatul , Ichsan Burhannudin , Cholisoh Zakky
Published: January 2024

The incidence of HIV infections in Papua is currently on the rise, primarily due to restricted access to antiretroviral treatment and insufficient support and care. Additionally, there is a lack of awareness among residents in rural or mountainous areas about HIV/AIDS infection, as provided by healthcare professionals. Until now, research data have been scarce on the demographic characteristics, clinical features, and treatment approaches for HIV/AIDS patients in the interior regions of Papua. This data is crucial for devising strategies aimed at enhancing healthcare services for individuals affected by HIV/AIDS.Consequently, this study endeavors to gain insights into the demographic characteristics, clinical features, and treatment modalities for HIV/AIDS patients at the Regional General Hospital of the Central Papua Region. It employs an observational descriptive approach, utilizing medical records of HIV/AIDS patients who visited the Central Papua Regional Government Hospital in June 2023. The findings indicate that, based on demographic data, the majority of patients were, on average, ≤25 years old (60.8%), male (52.5%), married (56.7%), and the highest number of HIV/AIDS cases were among secondary education graduates (40.8%). The majority were employed (67.5%) with incomes below the minimum wage threshold (69.2%). All heterosexual patients exhibited behavioral risk factors, and 4.2% had comorbidities such as hypertension. Tuberculosis was the most common opportunistic infection (17.5%). The highest proportion of individuals with HIV/AIDS were in stage II (66.7%). The predominant antiretroviral treatment regimen was a fixed-dose combination (FDC) containing Tenofovir 300mg, Lamivudine 300mg, and Efavirenz 600mg. The duration of use of ARV therapy in people with HIV / AIDS is at most 1 month.
Optimization of Soursop (Annona muricata L.) Leaf Extract in Nanoemulgel and Antiacnes Activity Test Against Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis Bacteria
Authors: Asyhari Hanif Fibiana , Cabral Kibedi B , Wikantyasning Erindyah R
Published: January 2024

Soursop leaf extract (Annona muricata L.) has antibacterial activity with active components of alkaloids, flavonoids, steroids, and saponins. This research aims to optimize the use of VCO, Tween 80, and PEG 400 in the nanoemulsion system, which will be added Carbopol 940 as a gelling agent to form a nanoemulgel and to determine antibacterial activity. By utilizing the simplex lattice design method in Design Expert 13.0, the nanoemulsion formula has been successfully optimized involving a mixture of VCO, Tween 80, and PEG 400. A total of 14 different nanoemulsion formulas were produced through this process. The process of making nanoemulsion is carried out by mixing extracts, oils, surfactants and cosurfactants, homogenized using a vortex, then sonicated. Evaluation of % transmittance, emulsification time, and pH were carried out to determine nanoemulsion physical properties. The nanoemulsion optimal formula was evaluated for particle size, polydispersity index, and zeta potential and made into nanoemulgel with the addition of Carbopol 940. The optimal formula has a composition of 10.86% VCO, 67.33% Tween 80, 21.81% PEG 400 form homogeneous and clear nanoemulsion with % transmittance of 91.97±1.11%, emulsification time of 56.42±0.72 seconds, and pH of 5.67±0.24. Particle size, polydispersity index, and zeta potential of the optimal formula were 229.47±38.79 nm, 0.41±0.10, and -39.13±0.19 mV, respectively. Evaluation of nanoemulgel physical properties showed homogeneous, pH value of 5.83±0.24, spreadability of 5.57±0.25 cm, adhesive force of 3.80±0.25 seconds, viscosity of 11479.33±167.49 cP, antibacterial activity against P. acnes, Staphylococcus aureus, and Staphylococcus epidermidis with inhibition zone diameters of 9.67±0.47 mm, 7.33±0.47 mm, and 5.67±0.47 mm. respectively. Nanoemulgel soursop leaf extract has suitable physical properties, and antibacterial activity is in the medium category.
Evaluation Of Medicine Storage Management and Compatibility With Storage Standards in The Pharmaceutical Warehouse of Hospital Badung Regency
Authors: Giwangkara I Gusti Agung Ayu Ningrat , Dewi Dewa Ayu Putu Satrya , Mayun I Gusti Ngurah , Suryaningsih Ni Putu Aryati
Published: January 2024

The effectiveness of drug storage is essential for effective drug management; if it is inadequate, pharmacy services and performance will be compromised. Therefore, a review of drug storage management and the appropriateness of drug storage regulations is required. The purpose of this study was to evaluate the effectiveness of drug storage and the acceptability of drug storage in the pharmaceutical warehouse of Hospital, Badung Regency. This study used cross-sectional methodology, descriptive observational quantitative research, and data collected from all medicinal products between March and April 2023. A checklist taken from the 2010 Binfar guidelines became the research tool. The result Indicators of drug storage such as percentage of matched drugs with stock cards was 100%, percentage of expired drugs was 1,46%, percentage of empty stock was 0%. Result of standards of drug storage such as space organized, drug supplies were prepared, and storage facilities were used was 100%. The results of the suitability of drug storage facilities in the Pharmacy Warehouse of Regional Hospital Badung Regency are in accordance with the standards of drug storage facilities, while the results of the efficiency value of drug storage in the Pharmacy Warehouse of Regional Hospital Badung Regency show that it has not achieved maximum results. Evaluation of drug storage management in the Pharmacy Warehouse of Regency Hospital Badung needs to be carried out regularly to prevent expired drugs and ensure drug supplies are maintained.
Nutritional Status and Quality of Life of Hemodialysis Patients in a Hospital in Yogyakarta
Authors: Siswandi Siswandi , Suhendra Gugun , Wulandari D , Simanjuntak LB , Dania Haafizah , Irham Lalu Muhammad , Faridah Imaniar , Adnan Adnan , Perwitasari Dyah Aryani
Published: January 2024

Kidney failure is a disease with a moderate prevalence in Indonesia but causes the second highest cost burden in Indonesia. One of the treatments for chronic kidney failure is hemodialysis. The problem with hemodialysis patients is a high incidence of malnutrition, which can affect the patient's quality of life. Therefore, this study will examine the relationship between nutritional status and quality of life in chronic kidney failure patients undergoing hemodialysis. This research is a cross-sectional study by collecting medical record data and filling out questionnaires. Selection of research subjects with inclusion criteria aged ≥18 years, routinely undergoing hemodialysis, willing to participate in the study and complete medical record data. The patient's nutritional status was seen from the Body Mass Index (BMI), and the patient's quality of life was assessed by the Indonesian version of the Kidney Disease Quality of Life Short-Form (KDQoL-SFTM) questionnaire. The average age of the hemodialysis patients in this study was 53.70 years, the average body weight was 57.24 kg and the average height was 10.82 cm. Patients with lean BMI were 20.5%, normal 56.4%, overweight 23.1%, and obesity 2.6%. The domain of employment status is related to nutritional status (p-value 0.005). Nutritional status is related to the quality of life of hemodialysis patients in the occupational status domain.