bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient-reported cosmetic satisfaction and the long-term association with quality of life in irradiated breast cancer patients
Authors:   the UMBRELLA study group, Batenburg M. C. T. , Gregorowitsch M. L. , Maarse W. , Witkamp A. , Young-Afat D. A. , Braakenburg A. , Doeksen A. , van Dalen T. , Sier M. , Schoenmaeckers E. J. P. , van Gils C. H. , van den Bongard H. J. G. D. , Verkooijen H. M.
Published: October 2019

Purpose

To evaluate patient-reported cosmetic satisfaction in women treated with radiation therapy for breast cancer and to determine the association between dissatisfaction and quality of life (QoL) and depression.

Methods

Within the prospective UMBRELLA breast cancer cohort, all patients ≥ 1 year after breast conserving treatment or mastectomy with immediate reconstruction were selected. Self-reported cosmetic satisfaction was measured on a 5-point Likert scale. QoL, social functioning, and emotional functioning were measured using EORTC QLQ-C30 and BR23 at 1, 2, and 3 years after inclusion. Mixed model analysis was performed to assess the difference in different domains of QoL between patients with good versus poor self-reported cosmetic satisfaction over time after adjustment for potential confounders. Depression scores were collected by means of the HADS-NL questionnaire. Chi-square test or Fisher's exact test was used to assess the difference in proportions of HADS score ≥ 8, indicating increased depression risk, between satisfied and dissatisfied patients.

Results

808 patients were selected for analysis. Respectively one, two, and three years after surgery, 8% (63/808), 7% (45/626), and 8% (31/409) of patients were dissatisfied with their cosmetic outcome. Poor patient-reported cosmetic satisfaction was independently associated with impaired QoL, body image, and lower emotional and social functioning. Scores ≥ 8 on the HADS depression subscale were significantly more common in dissatisfied patients.

Conclusions

Dissatisfaction with cosmetic outcome was low after breast cancer surgery followed by radiation therapy during 3 years follow-up. Knowing the association between dissatisfaction with cosmetic outcome and QoL and depression could help to improve the preoperative counseling of breast cancer patients.
Functional inhibition of F11 receptor (F11R/junctional adhesion molecule-A/JAM-A) activity by a F11R-derived peptide in breast cancer and its microenvironment
Authors: Bednarek Radoslaw , Selmi Anna , Wojkowska Dagmara , Karolczak Kamil , Popielarski Marcin , Stasiak Marta , Salifu Moro O. , Babinska Anna , Swiatkowska Maria
Published: October 2019

Purpose

To examine the involvement of the F11R/JAM-A protein in breast cancer metastasis, we utilized the F11R/JAM-A antagonistic peptide 4D (P4D) in experiments of transendothelial migration (TEM) of breast cancer cells.

Methods

Experiments were conducted in the mouse 4T1 breast cancer model utilizing the human mammary epithelial cell and endothelial cell lines. The levels of soluble F11R/JAM-A (sJAM-A) in the murine plasmas were measured by ELISA. Levels of F11R/JAM-A mRNA and protein in cell lines were assessed by qRT-PCR and Western blot, respectively. Cell surface expression of F11R/JAM-A was demonstrated by flow cytometry. Functional tests included the TEM of breast cancer cells and adhesion of breast cancer cells to the endothelium. The endothelial permeability was studied by fluorescent tracer assay and by the Real-Time Cell Analysis (RTCA).

Results

The tumor inducers Tβ4 and TGF-β1 reduced the levels of sJAM-A in murine plasma, and reduced the F11R/JAM-A protein levels in the human microvascular endothelial cell line HMEC-1. The adhesion and TEM measured between breast cancer cells and inflamed or Tβ4-treated endothelium were inhibited by P4D. The presence of P4D did not destabilize the pre-existing tight junctions in the endothelial monolayer. The barrier-protecting effect of P4D was stronger than that of forskolin, when a booster dose of P4D was applied to the inflamed endothelium.

Conclusions

F11R/JAM-A protein can be considered as a novel target in the treatment of breast cancer metastasis. In vivo and clinical studies are needed to further investigate the effectiveness of F11R/JAM-A-derived peptide as a possible anti-metastatic drug.
ParentWorks: Evaluation of an Online, Father-Inclusive, Universal Parenting Intervention to Reduce Child Conduct Problems
Authors: Piotrowska Patrycja J. , Tully Lucy A. , Collins Daniel A. J. , Sawrikar Vilas , Hawes David , Kimonis Eva R. , Lenroot Rhoshel K. , Moul Caroline , Anderson Vicki , Frick Paul J. , Dadds Mark R.
Published: October 2019

Evidence-based parenting interventions are effective in reducing conduct problems, yet these interventions have limited reach, and few involve the participation of fathers. This paper describes the outcomes of an open trial of ParentWorks, a universal, online, father-inclusive parenting intervention aiming to decrease childhood behavioural problems and promote positive parenting in mothers and fathers. A total of 388 families (456 individual parents; 36.6% fathers) were included in the study. Mixed model analyses showed significant decreases in child emotional/behavioural problems, dysfunctional parenting, interparental conflict, and parental mental health problems. The baseline severity of child behavioural problems significantly moderated the effects on child outcomes so that children with higher levels of problems benefitted more from the program. Participation of both caregivers in two-parent families, as well as parent sex, did not significantly affect the program outcomes. Results provide initial empirical support for the universal, self-directed, online parenting intervention, in addressing both child behavioural problems and parenting outcomes. Trial registration: ACTRN12616001223426, registered 05/09/2016.
Consistent Descriptions of Quantum Measurement
Authors: Yang Jianhao M.
Published: October 2019

The Wigner’s friend type of thought experiments manifest the conceptual challenge on how different observers can have consistent descriptions of a quantum measurement event. In this paper, we analyze the extended version of Wigner’s friend thought experiment (Frauchiger and Renner in Nat Commun 3711:9, 2018) in detail and show that the reasoning process from each agent that leads to the no-go theorem is inconsistent. The inconsistency is with respect to the requirement that an agent should make use of updated information instead of outdated information. We then apply the relational formulation of quantum measurement to resolve the inconsistent descriptions from different agents. In relational formulation of quantum mechanics, a measurement is described relative to an observer. Synchronization of measurement result is a necessary requirement to achieve consistent descriptions of a quantum system from different observers. Thought experiments, including EPR, Wigner’s Friend and it extended version, confirm the necessity of relational formulation of quantum measurement when applying quantum mechanics to composite system with entangled but space-like separated subsystems.
What’s So Queer About Morality?
Authors: Taylor Luke
Published: October 2019

Mackie (Ethics: inventing right and wrong, Penguin Books, London, 1977) famously argued for a moral error theory on the basis that objective moral values, if they existed, would be very queer entities. Unfortunately, his argument is very brief and it is not totally obvious from what he says exactly where the queerness of moral values is supposed to lie. In this paper I will firstly show why a typical interpretation of Mackie is problematic and secondly offer a new interpretation. I will argue that, whether or not we have reason to live in the morally correct way, what seems queer about moral properties is that there is a morally correct way in which to live in the first place. This interpretation makes sense of Mackie’s claim that theism might be able to solve the queerness problem; the notion of an objectively correct way to live may make sense if theism is true, but not otherwise.
Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?
Authors: Fernández-Veledo Sonia , Vendrell Joan
Published: October 2019

There is now a wealth of evidence showing that communication between microbiota and the host is critical to sustain the vital functions of the healthy host, and disruptions of this homeostatic coexistence are known to be associated with a range of diseases including obesity and type 2 diabetes. Microbiota-derived metabolites act both as nutrients and as messenger molecules and can signal to distant organs in the body to shape host pathophysiology. In this review, we provide a new perspective on succinate as a gut microbiota-derived metabolite with a key role governing intestinal homeostasis and energy metabolism. Thus, succinate is not merely a major intermediary of the TCA traditionally considered as an extracellular danger signal in the host, but also a by-product of some bacteria and a primary cross-feeding metabolite between gut resident microbes. In addition to maintain a healthy microbiome, specific functions of microbiota-derived succinate in peripheral tissues regulating host nutrient metabolism should not be rule out. Indeed, recent research point to some probiotic interventions directed to modulate succinate levels in the intestinal lumen, as a new microbiota-based therapies to treat obesity and related co-morbidities. While further research is essential, a large body of evidence point to succinate as a new strategic mediator in the microbiota-host cross-talk, which might provide the basis for new therapeutically approaches in a near future.
Diversity, innovation and entrepreneurship: where are we and where should we go in future studies?
Authors: Karlsson Charlie , Rickardsson Jonna , Wincent Joakim
Published: October 2019

In this paper, we review and comment upon the development of the literature on diversity, innovation, and entrepreneurship. In an overview of previous studies and various strands of literatures, we outline and argue that to better understand the intricate dynamic relationships between diversity, innovation, entrepreneurship, and regional development there is a strong need to further develop “the economics of spatial diversity.” We further argue that this development may benefit from combining various literatures based upon sound economic micro-foundations, to develop a more absolute understanding of diversity and fulfill the need of more clear mechanisms for future empirical testing. Obviously, this is important both from a research point of view and in order to provide policymakers with a powerful set of analytical tools. We call for more analytical work and more high-quality empirical studies. With a set of papers, we believe this special issue to provide a contribution in this direction.
Equilibrium and Kinetic Study of Ammonium Sorption by Raphia farinifera
Authors: Staroń Paweł , Sorys Paulina , Chwastowski Jarosław
Published: October 2019

The study investigated the sorption capacity of biosorbent-raphia sp. against ammonia. Raphia fibers were used without and with the modification of its surface with NaCl, NaNO3, and K2SO4. The data was analyzed in the state of equilibrium using four isotherm models such as Langmuir, Freudlich, Temkin, and Dubinin-Radushkevich. The equilibrium of ammonia sorption for all studied systems was best described by the Freudlich isotherm model. On its basis, it can be assumed that the studied process is of chemical nature, which results from the value of the coefficient 1/n < 1. In order to confirm the sorption mechanism, analysis of the kinetics of the ammonia sorption process on raphia fibers was performed. Four kinetic models of sorption were calculated: pseudo-first-order model, pseudo-second-order model, Elovich model, and Webber-Morris intermolecular diffusion model. The sorption kinetics of the modeled ammonia waste were carried out using unmodified palm fibers and all kinds of surface modification. This process was best described by the pseudo-second-order sorption model, which can be considered as a confirmation of the chemical nature of ammonia sorption on raphia sp. fibers.
Implications of smart decision-making and heuristics for production theory and material welfare
Authors: Altman Morris
Published: October 2019

Conventional theory assumes that economic agents perform at optimal levels of efficiency by definition and this is achieved when individuals behave in a particular fashion. Moreover, neoclassical production theory masks the process by which optimal output can be achieved. I argue that economic theory should be revised to incorporate some key findings of behavioural economics, while retaining the conventional theory’s normative ideal of optimum output whilst rejecting its normative procedural ideals of how to achieve optimality in production. I argue that neoclassical procedures can be expected to yield sub-optimal levels of output and therefore should not be benchmarks for procedural rationality. I present an alternative more realistic and analytically precise specification of the production function related to the fast and frugal heuristics narrative pioneered by Gigerenzer and Leibenstein’s x-efficient theory. This approach incorporates an understanding of the appropriate procedures, psychological and organization variables, decision-making capabilities and end-goals required to achieve optimality in production and, thereby, grow the wealth of nations, thereby enhancing the material wellbeing of the population at large. This also provides us with the tools to better identify economic inefficiency and the conditions that contribute to it.
Posterior Fusion for the Subaxial Cervical Spine: A Review of the Major Techniques
Authors: Mikhail Christopher M. , Dowdell James E. , Hecht Andrew C.
Published: October 2019

Posterior fusion is a powerful tool to address pathology of the cervical spine, but the decision to fuse at any level should be made with great care. Various methods and constructs for posterior cervical fusion exist, all of which aim to restore the posterior tension band's ability to resist flexion forces. We identified articles regarding posterior fusion of the subaxial cervical spine in MEDLINE, Google Scholar, and PubMed. This article is a narrative review of earlier and current concepts regarding the posterior fusion of the subaxial cervical spine, including wiring, translaminar screws, lateral mass screws, and pedicle screws, weighing the strengths and weakness of the different modalities that the surgeon should bear in mind in creating operative plans individualized to patient pathology.
Photothermal materials for efficient solar powered steam generation
Authors: Liu Fenghua , Lai Yijian , Zhao Binyuan , Bradley Robert , Wu Weiping
Published: October 2019

Solar powered steam generation is an emerging area in the field of energy harvest and sustainable technologies. The nano-structured photothermal materials are able to harvest energy from the full solar spectrum and convert it to heat with high efficiency. Moreover, the materials and structures for heat management as well as the mass transportation are also brought to the forefront. Several groups have reported their materials and structures as solutions for high performance devices, a few creatively coupled other physical fields with solar energy to achieve even better results. This paper provides a systematic review on the recent developments in photothermal nanomaterial discovery, material selection, structural design and mass/heat management, as well as their applications in seawater desalination and fresh water production from waste water with free solar energy. It also discusses current technical challenges and likely future developments. This article will help to stimulate novel ideas and new designs for the photothermal materials, towards efficient, low cost practical solar-driven clean water production.
Rescaling the energy label for washing machines: an opportunity to bring technology development and consumer behaviour closer together
Authors: Boyano Alicia , Espinosa Nieves , Villanueva Alejandro
Published: October 2019

Washing machines have in recent years incorporated programmes that are very energy- and water-efficient, but this entails a long programme duration, often beyond 4 h. These are also the programmes that the manufactures use to define, test and declare the overall water and energy efficiency of the machines. In response to these developments, there is evidence that consumers are reluctant to use excessively lengthy programmes, even if they are aware that the programmes are more energy-efficient.

This paper analyses this divergence of programme offer and programme use, which jeopardises the energy efficiency policy objectives for these appliances in the European Union (EU). The paper explores several policy measures to address this divergence, discussed in the context of the revision of the Ecodesign and Energy Labelling regulations that apply to washing machines in the EU.

Three different measures are studied: the provision of information about the programme duration on the energy label, the inclusion of time as an intrinsic parameter of the energy efficiency index calculations and the setting of a programme duration cap.

The paper concludes that introducing programme duration as an additional parameter of the energy efficiency index would result in the highest energy savings. However, this scenario is associated with significant uncertainties since competition among the manufacturers for a better energy label classification will not solely focus on energy efficiency aspects, and the outcome of such competition is unclear. The other two measures investigated are less effective but would also deliver savings. A programme duration cap would bring energy savings if consumers are aware of their existence and select the now shorter yet energy-efficient programmes more often. The provision of programme duration information on the energy label would also be effective but requires that consumers are able to correctly understand it.
A Pacchionian Puzzle
Authors: Nazir Khan M. , Shaw Brett H. , Wallace Carla J. , Metz Luanne
Published: October 2019

A 73-year-old male with a history of chronic ataxia presented with transient facial droop to the Emergency Department. A CT angiogram and MRI with diffusion weighted imaging (DWI) were negative for stroke. However, incidental note was made of numerous giant arachnoid granulation pits in the posterior fossa predominantly involving the left occipital bone (Figure 1). These arachnoid pits demonstrated multiple foci of herniation of the adjacent cerebellar parenchyma into the pits with gliosis of the herniated parenchyma and focal encephalomalacia of the subjacent cerebellar parenchyma. Review of bone windows on a remote CT brain performed almost 13 years earlier confirmed this to be a longstanding abnormality (Figure 2). The patient’s physical exam was suggestive of cerebellar ataxia with left-sided dysmetria on finger to nose testing and a wide-based unsteady gait.
Mapping the properties of the vortex-induced vibrations of flexible cylinders in uniform oncoming flow
Authors: Fan Dixia , Wang Zhicheng , Triantafyllou Michael S. , Karniadakis George Em
Published: October 2019

Flexible structures placed within an oncoming flow exhibit far more complex vortex-induced dynamics than flexibly mounted rigid cylinders, because they involve the distributed interaction between the structural and wake dynamics along the entire span. Hence, mapping the well-understood properties of rigid cylinder vibrations to those of strings and beams has been elusive. We show here with a combination of experiments, conducted at Reynolds number, $Re$ from 250 to 2300, and computational fluid dynamics that such a mapping is possible for flexible structures in uniform flow undergoing combined cross-flow and in-line oscillations, but only when additional concepts are introduced to model the extended coupling of the flow and the structure. The in-line response consists of largely standing waves that define cells, each cell spanning the distance between adjacent nodes, over which stable vortical patterns form, whose features (‘2S’ versus ‘P$+$S’) depend strongly on the true reduced velocity, $V_{r}=U/f_{y}d$, where $U$ is the inflow velocity, $f_{y}$ is the cross-flow vibration frequency and $d$ is the cylinder diameter, and the phase angle between in-line and cross-flow response; while the cross-flow response may contain travelling waves, breaking the symmetry of the problem. The axial distribution of the highly variable effective added masses in the cross-flow and in-line directions, and the local phase angle between in-line and cross-flow motion determine the single frequency of cross-flow response, while the in-line response vibrates at twice the cross-flow frequency. The cross-flow and in-line lift coefficients in phase with velocity depend strongly on the true reduced velocity but also on the local phase angle between in-line and cross-flow motions. Modal shapes can be defined for in-line and cross-flow, based on the resemblance of the response to conventional modes, which can be in the ratio of either ‘$2n/n$’ or ‘$(2n-1)/n$’, where $n$ is the order of the cross-flow response mode. We use an underwater optical tracking system to reconstruct the sectional fluid forces in a flexible structure and show that, once the cross-flow and in-line motion features are known, employing strip theory and the hydrodynamic coefficients obtained from forced rigid cylinder experiments allows us to predict the distributed forces accurately.
Instability of radially spreading extensional flows. Part 2. Theoretical analysis
Authors: Sayag Roiy , Worster M. Grae
Published: October 2019

The interface of a strain-rate-softening fluid that displaces a low-viscosity fluid in a circular geometry with negligible drag can develop finger-like patterns separated by regions in which the fluid appears to be torn apart. Such patterns were observed and explored experimentally in Part 1 using polymeric solutions. They do not occur when the viscosity of the displacing fluid is constant, or when the displacing fluid has no-slip conditions along its boundaries. We investigate theoretically the formation of tongues at the interface of an axisymmetric initial state. We show that finger-like patterns can emerge when circular interfaces of strain-rate-softening fluids displace low-viscosity fluids between stress-free boundaries. The instability, which is fundamentally different from the classical Saffman–Taylor viscous fingering, is driven by the tension that builds up along the circular front of the propagating fluid. That destabilising tension is a geometrical consequence and is present independently of the nonlinear properties of the fluid. Shear stresses stabilise the growth either along extended circumferential streamlines or through a street of vortices. However, such stabilising processes become weaker, thereby allowing the instability to develop, the more strain-rate-softening the fluid is. The theoretical model that we present predicts the main experimental observations made in Part 1. In particular, the patterns we predict using linear-stability theory are consistent with the strongly nonlinear experimental patterns. Our model depends on a single dimensionless number representing the power-law exponent, which implies that the instability we describe could arise in any extensional flow of strain-rate-softening material, ranging from suspensions that rupture in squeeze experiments to rifts formed in ice shelves.
Simultaneous and sequential collisions of three wetted spheres
Authors: Davis Robert H.
Published: October 2019

Rectilinear collisions of three wetted spheres are considered under conditions of high capillary numbers, for which viscous lubrication forces dominate over capillary forces. The viscous forces resist the relative motion, as characterized by the Stokes number (a dimensionless ratio of particle inertia and viscous forces). At high Stokes numbers, the particles penetrate the fluid layers between them with sufficient inertia that they collide and rebound. Both simultaneous and sequential collisions are simulated, and various outcomes are demonstrated: full agglomeration of the three spheres at low Stokes numbers, full separation or Newton’s cradle at large Stokes numbers and even reverse Newton’s cradle at intermediate Stokes numbers when there is a thicker combined fluid layer between the two target spheres than between the striker sphere and the first target sphere. When there is an initial air gap between the two target spheres, even more exotic outcomes are predicted, such as full separation after the initial collisions followed by full agglomeration or reverse Newton’s cradle (intermediate Stokes numbers) or Newton’s cradle (large Stokes numbers) after the subsequent collisions when the striker sphere catches back up to the target spheres. The approach and findings of this work are expected to provide input and guidance to future work on discrete-element modelling of collisions of many wet particles.
‘#Refugees can be entrepreneurs too!’ Humanitarianism, race, and the marketing of Syrian refugees
Authors: Turner Lewis
Published: October 2019

In the context of a greater focus on the politics of migration, the ‘refugee entrepreneur’ has become an increasingly important figure in humanitarian, media, and academic portrayals of refugees. Through a focus on Jordan's Za‘tari refugee camp, which has been deemed a showcase for refugees’ ‘entrepreneurship’, this article argues that the designation of Syrian refugees as ‘entrepreneurs’ is a positioning of Syrians within colonial hierarchies of race that pervade humanitarian work. For many humanitarian workers in Jordan, Syrians' ‘entrepreneurship’ distinguishes them from ‘African’ refugees, who are imagined as passive, impoverished, and dependent on humanitarian largesse. Without explicit racial comparisons, humanitarian agencies simultaneously market Syrian refugees online as ‘entrepreneurs’, to enable them to be perceived as closer to whiteness, and to thereby render them more acceptable to Western audiences and donors, who are imagined as white. This article extends scholarly understandings of the understudied relationship between race and humanitarianism. Furthermore, it asks critical questions about the political work and effects of vision of the ‘refugee entrepreneur’, which it locates within the context of the increasingly neoliberalised refugee regime. ‘Refugee entrepreneurs’ do not need political support and solidarity, but to be allowed to embrace the forces of free-market capitalism.
A BIBLIOMETRIC ANALYSIS OF SECOND LANGUAGE ACQUISITION BETWEEN 1997 AND 2018
Authors: Zhang Xian
Published: October 2019

This study used the bibliometric method to examine the field of second language acquisition (SLA) between 1997 and 2018 to provide a systematic overview of the field and to discover major trends in SLA. Based on citation/cocitation information and keywords retrieved from Web of Science, this study performed three types of bibliometric analyses to identify the prominent scholarly documents, authors, research institutions, geographic regions, and research topics that have been highly influential in the field of SLA over the last two decades. The scientific network maps and the keyword analysis revealed a number of significant changes as well as new trends in the field.
Pregabalin augmentation for resistant obsessive–compulsive disorder: a double-blind placebo-controlled clinical trial
Authors: Mowla Arash , Ghaedsharaf Mehrnoosh
Published: October 2019

Background and objective.

Glutamate dysfunction has been shown to be associated with pathophysiology of obsessive–compulsive disorder (OCD). Our objective is to survey the effects of pregabalin (a glutamate-modulating agent) as an augmenting treatment for resistant OCD.

Patients and methods.

In this 12-week double-blind placebo-controlled clinical trial, 56 patients with resistant OCD were randomly allocated to receive either pregabalin or placebo plus their current medication (sertraline). Yale–Brown Obsessive Compulsive Scale (Y-BOCS) was used to evaluate the outcomes. Adverse effects were also registered.

Results.

Of the 56 patients with resistant OCD who were randomly allocated in 2 groups of pregabalin (n = 28) and placebo group (n = 28), 42 patients (22 in pregabalin group and 20 in placebo group) completed the trial. Throughout the trial, the mean score decreased from 26.13± 7.03 to 8.81 ± 3.47 in the pregabalin group (p < 0) and from 26.85 ± 4.34 to 17.63 ± 4.22 in the placebo group (p < 0). At the end of trial, 16 (57.14%) patients in the pregabalin group and 2 (7.14%) patients in the placebo group showed more than 35% decline in YBOCS (p < .01). The pregabalin group showed good tolerability and safety.

Conclusions.

Our study revealed that pregabalin, as an augmenting medication, is more effective than placebo in the treatment of patients with resistant OCD.
Evaluating VERT as a radiotherapy plan evaluation tool: comparison with treatment planning software
Authors: Bridge P. , Kirby M. C. , Callender J. A.
Published: October 2019

Introduction:

The virtual environment for radiotherapy training (VERT) helps students to gain technical skills and understanding of 3D anatomy and dosimetry. It has potential as a tool for treatment plan evaluation, although little formal evidence currently supports this.

Aim:

This paper reports findings from a plan evaluation workshop that facilitated comparison of VERT plan evaluation tools with those provided by conventional treatment planning software (TPS).

Method:

Students on a pre-registration Post-Graduate Diploma in Radiotherapy worked in small groups evaluating lung plans using both VERT and Eclipse TPS tools. All students were invited to provide ratings concerning how helpful each modality was for a range of evaluation parameters and preferences for use.

Results:

Most students (11 out of 14) found the session useful and expressed a desire to use VERT in future plan evaluation. The TPS was perceived to be more helpful with constraint-based evaluation while VERT was more helpful with evaluating plans for clinical set-up and delivery (p < 0·001).

Conclusion:

Student therapeutic radiographers found VERT to be helpful as a plan evaluation tool alongside standard TPS tools, in particular for clinical set-up and delivery aspects of planning. Future work is ongoing to identify the specific impact of VERT as a plan evaluation tool for both students and qualified planners.
Enhancing understanding of food purchasing patterns in the Northeast US using multiple datasets
Authors: Palmer Anne , Bonanno Alessandro , Clancy Kate , Cho Clare , Cleary Rebecca , Lee Ryan
Published: October 2019

Due to correlations between purchasing patterns and diet disparities, differences in food shopping patterns and strategies across income levels and other socio-economic characteristics is a widely-studied research area. Most extant literature uses either primary or secondary data, which are often characterized by, respectively, limited geographical scope and considerable level of detail, or wide geographical reach but low detail. That literature also reveals contrasting results based on methods, data sources and geographic location. In this paper, we use three different datasets to characterize the differences in purchasing patterns across income levels, rural–urban status and other variables of food shoppers in the Northeastern USA and compare these trends with existing research. While many of the findings corroborate previous studies, new findings include less reliance on superstores overall, except for rural respondents, and a greater reliance on limited assortment supermarkets for SNAP and low-income households. Food purchasing differences are described by race and ethnicity, income and education, and children in the household. The analysis presented here includes a portion of the work performed by an interdisciplinary team of researchers engaged in the USDA National Institute of Food and Agriculture's Agriculture and Food Research Initiative project Enhancing Food Security in the Northeast (EFSNE). By using primary data from shoppers' intercept surveys, and secondary data from two large datasets, one of household food purchases and the other of food expenditures, we identify purchasing decisions holding at both the case-study (limited geography) and broader geographic (entire Northeast) levels, which both support previous findings and reveal the need for additional research in this area.
The association between household socio-economic status, maternal socio-demographic characteristics and adverse birth and infant growth outcomes in sub-Saharan Africa: a systematic review
Authors: Ngandu Christian Bwangandu , Momberg Douglas , Magan Ansuyah , Chola Lumbwe , Norris Shane A. , Said-Mohamed Rihlat
Published: October 2019

Adverse birth outcomes and infant undernutrition remain the leading causes of morbidity and mortality in sub-Saharan Africa (SSA). Impaired infant growth and development, which often begins during foetal development, may persist during the first 2 years of life and has been associated with higher risks of cardiometabolic diseases. This systematic review assessed the associations between maternal demographic characteristics and household socio-economic status (SES), and preterm birth (PTB), small for gestational age, low birth weight (LBW), stunting, wasting and underweight in children under 2 years of age in SSA countries. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, we searched for publications in three electronic databases (PubMed, Scopus and ScienceDirect). Eleven studies on children under 2 years of age, in four SSA regions, published in English between 1990 and 2018, were included. All the studies were observational in design (cross-sectional or cohort studies). Maternal education was the most commonly explored exposure. Most studies (63.3%) focused on undernutrition during the first 2 years of life: LBW, PTB and stunting. Lower maternal education, maternal unemployment and lower household wealth index were the SES factors most commonly associated with adverse birth outcomes and infant undernutrition. Maternal marital status was not associated with any infant outcomes. The definitions of the SES varied, which may explain discrepancies between studies. Nutrition intervention programs in SSA need to promote education and poverty alleviation in women at reproductive age, starting from pre-pregnancy, to optimise infant growth and development and prevent the increase in the prevalence of cardiometabolic diseases.
Prevalence of suicide attempts in bipolar disorder: a systematic review and meta-analysis of observational studies
Authors: Dong Min , Lu Li , Zhang Ling , Zhang Qinge , Ungvari Gabor S. , Ng Chee H. , Yuan Zhen , Xiang Yifan , Wang Gang , Xiang Yu-Tao
Published: October 2019

Aims

Bipolar disorder (BD) is a severe psychiatric disorder associated with a high risk of suicide. This meta-analysis examined the prevalence of suicide attempts (SA) in patients with BD and its associated factors.

Methods

A systematic literature search was conducted in the PubMed, PsycINFO, EMBASE and Web of Science databases from their inception to 11 June 2018. The prevalence of SA in BD was synthesised using the random-effects model.

Results

The search identified 3451 articles of which 79 studies with 33 719 subjects met the study entry criteria. The lifetime prevalence of SA was 33.9% (95% CI 31.3–36.6%;I2= 96.4%). Subgroup and meta-regression analyses revealed that the lifetime prevalence of SA was positively associated with female gender, BD-I, BD Not Otherwise Specified and rapid cycling BD subtypes, income level and geographic region.

Conclusion

This meta-analysis confirmed that SA is common in BD and identified a number of factors related to SA. Further efforts are necessary to facilitate the identification and prevention of SA in BD. Long-term use of mood stabilisers coupled with psycho-social interventions should be available to BD patients to reduce the risk of suicidal behaviour.
High‐Speed Video Observations of Natural Lightning Attachment Process With Framing Rates up to Half a Million Frames per Second
Authors: Qi Qi , Lyu Weitao , Ma Ying , Wu Bin , Chen Lyuwen , Jiang Ruijiao , Zhu Yanan , Rakov Vladimir A.
Published: October 2019

Using high‐speed video cameras operating with framing rates of 20 and 525 kfps, we imaged the attachment process of a natural negative cloud‐to‐ground flash, occurring at a distance of 490 m. Nine upward leaders were observed. A total of 12 space stems/leaders in 47 steps of the downward negative stepped leader were captured. The two‐dimensional length of them was between 2.0 and 5.9 m, with an average of 3.0 m. The average interstep interval, step length, and two‐dimensional speed of the downward negative leader and that of upward positive leader were statistically analyzed. The last step of the downward negative leader making contact with the upward connecting leader was recorded. The two‐dimensional length of the final imaged gap between the tips of opposite‐polarity leaders was estimated to be about 13 m.
Invariant NKT cells facilitate cytotoxic T-cell activation via direct recognition of CD1d on T cells
Authors: Qin Yingyu , Oh Sejin , Lim Sojung , Shin Jung Hoon , Yoon Min Sang , Park Se-Ho
Published: October 2019

Invariant natural killer T (iNKT) cells are a major subset of NKT cells that recognize foreign and endogenous lipid antigens presented by CD1d. Although iNKT cells are characteristically autoreactive to self-antigens, the role of iNKT cells in the regulation of cytotoxic T lymphocytes (CTL) has been elucidated using α-galactosylceramide (α-GalCer), a strong synthetic glycolipid that is presented by professional antigen presenting cells (APCs), such as dendritic cells. Despite the well-known effects of α-GalCer and dendritic cells on lipid antigen presentation, the physiological role of endogenous antigens presented by CTLs during crosstalk with iNKT cells has not yet been addressed. In this study, we found that antigen-primed CTLs with transient CD1d upregulation could present lipid self-antigens to activate the iNKT cell production of IFN-γ. CTL-mediated iNKT cell activation in turn enhanced IFN-γ production and the proliferation and cytotoxicity of CTLs. We also found that the direct interaction of iNKT cells and CTLs enhanced the antitumor immune responses of CTLs. This partially explains the functional role of iNKT cells in CTL-mediated antitumor immunity. Our findings suggest that in the absence of exogenous iNKT cell ligands, iNKT cells enhanced the CTL production of IFN-γ and CTL proliferation and cytotoxicity via direct interaction with CD1d expressed on T cells without interacting with APCs.
Lysosome restoration to activate podocyte autophagy: a new therapeutic strategy for diabetic kidney disease
Authors: Liu Wei Jing , Gan Yu , Huang Wei Fang , Wu Hong-luan , Zhang Xue-qin , Zheng Hui Juan , Liu Hua-feng
Published: October 2019

Autophagy, the intracellular lysosomal degradation process plays a pivotal role in podocyte homeostasis in diabetic kidney disease (DKD). Lysosomal function, autophagic activity, and their actions were investigated in vitro and in vivo. We found that LC3-II- and p62-positive vacuoles accumulated in podocytes of patients with DKD. Moreover, we found that advanced glycation end products (AGEs) could increase the protein expression of LC3-II and p62 in a dose- and time-dependent manner in cultured podocytes. However, the mRNA expression of LC3B, Beclin-1 or ATG7, as well as the protein level of Beclin-1 or ATG7 did not change significantly in the AGE-treated cells compared with that in control groups, suggesting that AGEs did not induce autophagy. In addition, AGEs led to an increase in the number of autophagosomes but not autolysosomes, accompanied with a failure in lysosomal turnover of LC3-II or p62, indicating that the degradation of autophagic vacuoles was blocked. Furthermore, we observed a dramatic decrease in the enzymatic activities, and the degradation of DQ-ovalbumin was significantly suppressed after podocytes were treated with AGEs. Plasma-irregular lysosomal-associated membrane protein 1 granules accompanied with the diffusion of cathepsin D expression and acridine orange redistribution were observed in AGE-treated podocytes, indicating that the lysosomal membrane permeability was triggered. Interestingly, we also found that AGEs-induced autophagic inhibition and podocyte injury were mimicked by the specific lysosomotropic agent, l-leucyl-l-leucine methyl ester. The exacerbated apoptosis and Rac-1-dependent actin-cytoskeletal disorganization were alleviated by an improvement in the lysosomal-dependent autophagic pathway by resveratrol plus vitamin E treatment in AGE-treated podocytes. However, the rescued effects were reversed by the addition of leupeptin, a lysosomal inhibitor. It suggests that restoring lysosomal function to activate autophagy may contribute to the development of new therapeutic strategies for DKD.
PROTAC induced-BET protein degradation exhibits potent anti-osteosarcoma activity by triggering apoptosis
Authors: Shi Chengcheng , Zhang Huapeng , Wang Penglei , Wang Kai , Xu Denghui , Wang Haitao , Yin Li , Zhang Shuijun , Zhang Yi
Published: October 2019

Targeting oncogenic proteins for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing attention in the field of cancer research. Bromodomain and extra-terminal (BET) family proteins are newly identified cancer-related epigenetic regulators, which have a role in the pathogenesis and progression of osteosarcoma. In this study, we investigated the in vitro and in vivo anti-osteosarcoma activity by targeting BET with a PROTAC molecule BETd-260. The results showed that BETd-260 completely depletes BET proteins and potently suppresses cell viability in MNNG/HOS, Saos-2, MG-63, and SJSA-1 osteosarcoma cell lines. Compared with BET inhibitors HJB-97 and JQ1, the activity of BETd-260 increased over 1000 times. Moreover, BETd-260 substantially inhibited the expression of anti-apoptotic Mcl-1, Bcl-xl while increased the expression of pro-apoptotic Noxa, which resulted in massive apoptosis in osteosarcoma cells within hours. In addition, pro-oncogenic protein c-Myc also was substantially inhibited by BETd-260 in the OS cells. Of note, BETd-260 induced degradation of BET proteins, triggered apoptosis in xenograft osteosarcoma tumor tissue, and profoundly inhibited the growth of cell-derived and patient-derived osteosarcoma xenografts in mice. Our findings indicate that BET PROTACs represent a promising therapeutic agent for human osteosarcoma.
Data driven discovery of cyber physical systems
Authors: Yuan Ye , Tang Xiuchuan , Zhou Wei , Pan Wei , Li Xiuting , Zhang Hai-Tao , Ding Han , Goncalves Jorge
Published: October 2019

Cyber-physical systems embed software into the physical world. They appear in a wide range of applications such as smart grids, robotics, and intelligent manufacturing. Cyber-physical systems have proved resistant to modeling due to their intrinsic complexity arising from the combination of physical and cyber components and the interaction between them. This study proposes a general framework for discovering cyber-physical systems directly from data. The framework involves the identification of physical systems as well as the inference of transition logics. It has been applied successfully to a number of real-world examples. The novel framework seeks to understand the underlying mechanism of cyber-physical systems as well as make predictions concerning their state trajectories based on the discovered models. Such information has been proven essential for the assessment of the performance of cyber-physical systems; it can potentially help debug in the implementation procedure and guide the redesign to achieve the required performance.
DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
Authors: Milanese Chiara , Bombardieri Cíntia R. , Sepe Sara , Barnhoorn Sander , Payán-Goméz César , Caruso Donatella , Audano Matteo , Pedretti Silvia , Vermeij Wilbert P. , Brandt Renata M. C. , Gyenis Akos , Wamelink Mirjam M. , de Wit Annelieke S. , Janssens Roel C. , Leen René , van Kuilenburg André B. P. , Mitro Nico , Hoeijmakers Jan H. J. , Mastroberardino Pier G.
Published: October 2019

Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metabolic redesign upon genomic instability, however, is highly rudimentary. Using Ercc1-defective mice and Xpg knock-out mice, we demonstrate that combined defects in transcription-coupled DNA repair (TCR) and in nucleotide excision repair (NER) directly affect bioenergetics due to declined transcription, leading to increased ATP levels. This in turn inhibits glycolysis allosterically and favors glucose rerouting through the pentose phosphate shunt, eventually enhancing production of NADPH-reducing equivalents. In NER/TCR-defective mutants, augmented NADPH is not counterbalanced by increased production of pro-oxidants and thus pentose phosphate potentiation culminates in an over-reduced redox state. Skin fibroblasts from the TCR disease Cockayne syndrome confirm results in animal models. Overall, these findings unravel a mechanism connecting DNA damage and transcriptional stress to metabolic redesign and protective antioxidant defenses.
Anomalous hydrogen evolution behavior in high-pH environment induced by locally generated hydronium ions
Authors: Wang Xuesi , Xu Chaochen , Jaroniec Mietek , Zheng Yao , Qiao Shi-Zhang
Published: October 2019

Most fundamental studies of electrocatalysis are based on the experimental and simulation results obtained for bulk model materials. Some of these mechanistic understandings are inapplicable for more active nanostructured electrocatalysts. Herein, considering the simplest and most typical electrocatalytic process, the hydrogen evolution reaction, an alternative reaction mechanism is proposed for nanomaterials based on the identification of a new intermediate, which differs from those commonly known for the bulk counterparts. In-situ Raman spectroscopy and electrochemical thermal/kinetic measurements were conducted on a series of nanomaterials under different conditions. In high-pH electrolytes with negligible hydronium (H3O+) concentration in bulk phase, massive H3O+ intermediates are found generating on the catalytic surface during water dissociation and hydrogen adsorption processes. These H3O+ intermediates create a unique acid-like local reaction environment on nanostructured catalytic surfaces and cut the energy barrier of the overall reaction. Such phenomena on nanostructured electrocatalysts explain their widely observed anomalously high activity under high-pH conditions.
Cortical astrocytes develop in a plastic manner at both clonal and cellular levels
Authors: Clavreul Solène , Abdeladim Lamiae , Hernández-Garzón Edwin , Niculescu Dragos , Durand Jason , Ieng Sio-Hoï , Barry Raphaëlle , Bonvento Gilles , Beaurepaire Emmanuel , Livet Jean , Loulier Karine
Published: October 2019

Astrocytes play essential roles in the neural tissue where they form a continuous network, while displaying important local heterogeneity. Here, we performed multiclonal lineage tracing using combinatorial genetic markers together with a new large volume color imaging approach to study astrocyte development in the mouse cortex. We show that cortical astrocyte clones intermix with their neighbors and display extensive variability in terms of spatial organization, number and subtypes of cells generated. Clones develop through 3D spatial dispersion, while at the individual level astrocytes acquire progressively their complex morphology. Furthermore, we find that the astroglial network is supplied both before and after birth by ventricular progenitors that scatter in the neocortex and can give rise to protoplasmic as well as pial astrocyte subtypes. Altogether, these data suggest a model in which astrocyte precursors colonize the neocortex perinatally in a non-ordered manner, with local environment likely determining astrocyte clonal expansion and final morphotype.