bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposta de implementação de novas práticas de gestão financeira e administrativa no ponto do açaí: rumo à estabilidade operacional
Authors: Vilhena Ruan Campos , Cruz Natanael Esdras Pereira de Carvalho , Roberto José Carlos Alves , Pinto Junior José Roberto Lira
Published: October 2024

O presente artigo tem como objetivo explorar a adoção de novas práticas na gestão financeira e administrativa da empresa Ponto do Açaí, visando promover maior estabilidade e eficiência nas suas atividades. Considerada uma microempresa de caráter familiar, a organização enfrenta desafios nas áreas financeira e administrativa, identificados por meio de uma pesquisa diagnóstica. Assim, a questão central deste estudo é: como a implementação de novas práticas de gestão financeira e administrativa pode conduzir a empresa à estabilidade e ao aumento da eficiência operacional? O principal objetivo é implementar técnicas inovadoras nessas áreas, enfatizando sua importância para alcançar uma operação mais eficaz. A pesquisa adota uma abordagem qualitativa, de natureza exploratória e intervencionista, focando na identificação de problemas e na proposição de soluções adequadas. Para isso, foi realizado um estudo de caso, com coleta de dados primários por meio de entrevistas e observações diretas, permitindo uma compreensão mais aprofundada das dificuldades enfrentadas. Os resultados esperados incluem a implementação efetiva das ações recomendadas, apresentadas pela ferramenta 5W2H, com a intenção de otimizar os processos administrativos e financeiros da organização. Espera-se que a adoção dessas estratégias traga melhorias significativas na eficiência operacional, contribuindo para o fortalecimento do Ponto do Açaí no mercado e trazendo benefícios para colaboradores e clientes.
The Application of AI Art in New Media Art Design
Authors: Hu Tingting
Published: October 2024

With the continuous development of AI technology, the combination of AI and new media art design will be more in-depth, and more innovative application scenarios can be explored in the future, such as the combination of virtual reality (VR) and augmented reality (AR) with AI, to provide customers with a more immersive experience. With the assistance of AI, new media art design has created more diversified and innovative works, which has improved the design ability and aesthetic level of new media art. It is more in line with the needs of the new media art design industry and enhances the employment competitiveness.
A Bibliometric Review of Research on Gamification in Education: Reflections for Moving Forward
Authors: Zhang Yong , Tan Wee Hoe , Zhou Jun
Published: October 2024

As the field of education continuously explores innovative teaching methods, gamified education has attracted widespread attention due to its unique mechanisms for stimulating learning motivation and enhancing engagement. This study utilizes bibliometric analysis to systematically evaluate the development of gamified education research from 2004 to 2023. By analyzing 4,373 publications, this research reveals the major trends and academic impacts of gamified education, finding that the United States and China are particularly prominent in research output in this field. The results indicate that gamified education can effectively enhance students' learning motivation and engagement, especially in remote and digital learning environments. Additionally, this study also finds that, despite the increasing research on gamified education, further exploration is needed regarding its long-term effects and specific applications in educational practice.
Breaking through the Key Challenges to Further Electrification of Public Transport in Beijing
Authors: Zhang Baocheng
Published: October 2024

In recent years, with the improvement of people's awareness of environmental protection and the increasingly serious problem of urban traffic congestion, the Beijing Municipal Government has actively promoted the development of green transportation, among which electric buses, as a low-carbon, environmentally friendly and energy-saving mode of transportation, are regarded as an important measure to improve air quality and reduce pollution emissions, which has attracted much attention. As electric buses grow, so do the operational challenges of the promoted electric buses, including high initial investment costs, inadequate charging infrastructure, technical limitations in terms of vehicle range and charging speed, and a lack of more supportive policies and regulations. This paper summarizes and analyzes the current situation of electric buses in Beijing.  And proposes to solve the challenges encountered in the operation of electric buses by implementing targeted strategies. For example, optimize government financial subsidy measures and implement diversified financial support; The government supports companies to carry out technological innovation and invest in R&D to enhance electric vehicle technology; further promote the construction of charging infrastructure and improve the level of charging services; Effectively deploy battery recycling; promote the integrated development of intelligent vehicles and networking, and accelerate the construction of intelligent public transportation systems; strengthening international cooperation and resource sharing; and the development of a comprehensive policy to promote and facilitate the electrification of public transport in Beijing. Inject new impetus into Beijing's sustainable urban development.
Taylor's formula on the separating complex plane and its applications
Authors: Li Zehui , Fan Yitong , Sun Qianhao
Published: October 2024

This article begins by exploring split-complex numbers, also known as dual or double numbers, a mathematical concept that extends the real number system by creating a commutative ring with a zero divisor. Furthermore, the paper extends the Taylor series theory from the real analysis domain to the domain of split-complex numbers, thereby establishing the corresponding Taylor formula on the split-complex plane. The introduction of split-complex numbers opens up new perspectives and provides new tools for the modeling and analysis of quantum systems. In the field of electromagnetism, the application of split-complex numbers also demonstrates its potential, contributing to a more precise description of the behavior of electromagnetic fields under specific conditions. These theoretical advancements are expected to further promote research in the field of split-complex analysis, playing a more critical role in important branches of physics such as quantum mechanics and electromagnetism, thereby facilitating the development of related theories and the emergence of innovative practical applications.
Beyond Traditional Forecasting: Machine Learning and Adaptive Algorithms in EV Sales Predictions
Authors: Teng Fei
Published: October 2024

The Electric Vehicle market is growing fast, creating new challenges for sales predictions and market dynamics. Traditional forecasting methods like linear regression and expert judgment struggle with the market's non-linear and complex nature. To improve accuracy, new models such as machine learning and Adaptive Optimized Grey Models are being applied to predict EV sales, which is discussed in this review paper. These models dynamically adjust parameters and account for external factors, offering better precision. AOGMs, in particular, utilize data preprocessing and buffering to minimize external disturbances and enhance prediction smoothness. Techniques like the Particle Swarm Optimization help these models more effectively capture the EV sales trends. Additionally, adaptive grey models are not only essential for forecasting sales but also for identifying market risks like overcapacity or supply shortages. These advanced methods provide a more robust framework for understanding and anticipating changes in the rapidly evolving the EV market.
Applications and Advances of UCB Algorithms in Dynamic and Contaminated Environments
Authors: Du Mengxuan
Published: October 2024

The Upper Confidence Bound (UCB) algorithm is a widely used approach in the Multi-Armed Bandit (MAB) problem, where the goal is to maximize cumulative rewards over time by selecting the best possible action among several options. The UCB algorithm uses confidence bounds to balance exploration and exploitation, guiding its decision-making. In recent years, researchers have identified significant challenges in applying the UCB algorithm to dynamic and contaminated environments. In such scenarios, the underlying conditions may change over time, making it difficult for standard UCB to adapt, or the data may be polluted by noise and outliers, leading to incorrect estimations of reward distributions. To address these challenges, several variants of the UCB algorithm have been developed. These new approaches are designed to better handle the complexities of changing environments and data contamination, ensuring more robust and reliable performance in these difficult settings. This paper aims to provide a comprehensive review of Robust-UCB (cr-UCB), Sliding Window UCB (SW-UCB) and bandit-over-bandit UCB (BOB-UCB). Focusing on their theoretical foundations, practical applications, and empirical performance. By examining how these algorithms have been adapted to handle the complexities of dynamic and contaminated environments, we found that the adaptability of these algorithms in dynamic environments is significantly improved, and they can effectively reduce decision-making errors caused by data pollution, thus providing a more reliable solution to the multi-armed bandit problem.
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Authors: withdraw withdraw
Published: October 2024

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Enhancing Consumer Loyalty and Market Competitiveness: Approaching IPA-QFD in Product Development
Authors: Syaifuddin Aldy Hamid , Ambarwati Rita , Sari Dewi Komala
Published: October 2024

This paper provides an overview of AA.co.Store, is a fashion business founded in 2021. Despite being in the development stage, AA.co.Store can compete with other local brands in Sidoarjo. To maintain and attract more consumers, the company focuses on improving product quality. The success of a business is measured by the number of products produced and their competitiveness in the market. Product development is crucial to increase competitiveness and attract future consumers. The quality of the product and promotional activities significantly impact customer satisfaction. Pricing and distribution also influence purchasing decisions. To compete with competitors, AA.co.Store needs a comprehensive strategy. Research suggests that product quality, price, customer satisfaction, and brand image affect consumer loyalty and satisfaction. The purpose of this research is to improve AA.co.Store's product development using an IPA-QFD-based marketing mix aligned that very important for Development Goals (SDGs) of the store to compete with other local brands in Sidoarjo. The results of this study were AA.co.Store service quality, it can be concluded that Customer satisfaction with AA.co.Store services is fulfilled, which is indicated by the results of the questionnaire using the SERVQUAL method which does not show a negative value for the AA.co.Store brand when compared to other brands. There are three service quality attributes that need to be prioritised for improvement at AA.co.Store, namely the price of t-shirts that are more competitive than other brands, the condition of the parking lot, and cleanliness. There are several steps that can be taken to improve service quality based on technical needs, including: a.) changing the organisational strategy on company performance, especially in the operational section, b.) increasing the stock of materials to meet the number of orders, c.) providing training and development on existing SOPs, and d.) repairing and maintaining existing equipment in the company.
D’Cika Building Customer Satisfaction Through Superior Service Quality
Authors: Fitri Sofianah , Supendi Moh
Published: October 2024

This study examines the impact of service quality on customer satisfaction at D'Cika Jatimakmur. D'Cika's service needs improvement because only a few customers are satisfied. The store needs optimal service to maintain a positive reputation. This research uses the Lemeshow formula to obtain a sample size of 100 respondents. The sampling technique of this study was non-probability purposive sampling. The researchers distributed questionnaires to customers of D'Cika, with the respondents identified as those who had made at least one cake purchase. The data collected is then processed and analyzed using the SPSS 25. The findings of this study indicate that service quality has a positive and significant effect on customer satisfaction. Specifically, the results of the simple regression analysis indicate that the constant coefficient value is 2.077, and the independent variable is 0.487. These results indicate that when the service quality (X) is at its lowest level, customer satisfaction (Y) is positive by 2.077. The R square test yielded a value of 0.547, indicating that service quality significantly influences customer satisfaction. The results of the T-test indicate a significance value of 0.000, which is less than 0.05. Consequently, the researcher concludes that alternative hypothesis (Ha), which states that there is a positive and significant influence between service quality and customer satisfaction at D'Cika, is accepted.
Functional equations in formal power series
Authors: Pakovich Fedor
Published: October 2024

Let \(k\) be an algebraically closed field of characteristic zero, and \(k[[z]]\) the ring of formal power series over \(k\). In this paper, we study equations in the semigroup \(z^2k[[z]]\) with the semigroup operation being composition. We prove a number of general results about such equations and provide some applications. In particular, we answer a question of Horwitz and Rubel about decompositions of "even" formal power series. We also show that every right amenable subsemigroup of \(z^2k[[z]]\) is conjugate to a subsemigroup of the semigroup of monomials.
Orthokeratologie bei hoher Myopie
Authors: Bong Anna
Published: October 2024

Purpose. With an increasing proportion of children with myopia especially in Asia, efforts have been made to reduce chances of preventable sight loss related to high myopia in the future. Orthokeratology lens has been used as one of the modalities not just to correct myopia, but also to slow down myopic progression and axial elongation. This case report reviews a patient with clinically significantly high myopia, whose refractive errors was partially corrected with orthokeratology lens and spectacle lenses. Material and Methods. A now 14-year-old patient with a history of fast progressing myopia, was prescribed and commended orthokeratology to manage myopia, while regularly monitoring her refractive errors, axial length, binocular vision status, corneal topography, and anterior eye health was monitored regularly at the author’s practice. Results. Over a two year follow up period, a partial correction of high myopia with orthokeratology lenses and residual refractive errors with additional spectacle lenses was effective in managing this patient’s myopia, as well as slowing of axial elongation. An updated pair of orthokeratology lens with a steeper back optic zone radii were prescribed to reduce superficial corneal staining and to maintain corneal health. Conclusion. Patient commitment and adherence to close monitoring of eyes in terms refractive errors, axial length, and anterior eye health, are vital in achieving a successful orthokeratology lens wear for high myopia. A dual fitting strategy consisting of orthokeratology lens and spectacle wear can be a safe management strategy that is acceptable for patients with high myopia. It would be helpful for practitioners to be able to rely on robust evidence-based guidance when determining whether lens wear can be ceased, i.e. when further axial elongation and myopic progression are no longer likely.
Anpassung von Sklerallinsen bei Unverträglichkeit von Korneallinsen nach Keratoplastik
Authors: Schwarz Tim , Rein Eric
Published: October 2024

Purpose. The aim of this case report is to describe the treatment of a 47-year-old man with scleral lenses due to intolerance of corneal contact lenses after keratoplasty as a result of keratoconus. Material and Methods. The initial examinations included visual acuity tests, slit lamp examination and detailed corneal topography using Keratograph 5M and Pentacam AXL Wave. Based on these measurements, scleral lenses were fitted to improve visual acuity and wearing comfort of the contact lenses. Results. The fitted scleral lenses were subjectively and objectively tolerated without complications the whole day. The visual acuity improved from 0.05 to 1.0 in the right eye and from 0.80p to 1.00 in the left eye. Conclusion. The fitting of scleral lenses offers many advantages over corneal lenses in cases of corneal ectasia or dry eyes. In this case, scleral lenses provided significantly improved visual results and comfort. Regular follow-up examinations were scheduled to ensure safe and complication-free vision with the contact lenses.
Wirksamkeit transkutaner periorbitaler Elektrostimulation mittels Quantum-Molekular-Resonanz (QMR) bei Keratoconjunctivitis Sicca
Authors: Kroll Sandra , Knisch Manuela , Liekfeld Anja
Published: October 2024

Purpose. Transcutaneous periorbital electrical stimulation is a patented electrophysical method (QMR) for treating both the hyposecretory and hyperevaporative components of sicca syndrome, which is used as part of the Rexon-Eye procedure. The aim of the study is to determine the efficacy of this method in patients with keratoconjunctivitis sicca. Material and Methods. As part of a randomized, double-blind, prospective observational study, 56 patients (112 eyes) were examined. 29 patients were treated with the Rexon Eye Procedure. 27 patients belonged to the placebo group and therefore only received a sham treatment. Subjective symptoms (OSDI questionnaire) and objective parameters relating to the lacrimal gland, eyelids and ocular surface and the number of drops/drop frequency were recorded. The treatment interval was 4 applications, once a week. The follow ups were carried out one week and 3 and 6 months after the last treatment. Results. OSDI-Score: There was a significant improvement in all follow-up checks during treatment as well as in the placebo group. The OSDI score reduced from 54 initially to 40 points in the treatment group after 3 months (p = 0.001) and from 50 to 41 points in the placebo group (p = 0.03). The number of artificial tears used as well as their drop frequency was significantly reduced in both groups after 3 months of follow-up. The number of tear substitutes used decreased by −0.44 ± 0.89 (p = 0.017) in the treatment group and by −0.48 ± 0.95 (p = 0.009) in the placebo group after 3 months. The drop frequency also decreased significantly after 3 months, in the treatment group by −1.5 ± 3.65 (p = 0.006) and in the placebo group by −1.3 ± 2.3 (p = 0.013). A significant increase in BUT of 1.3 ± 2.6 (p = 0.02) was found in the treatment group after 3 months – but not in the placebo group. Signs of blepharitis appeared significantly lower in the treatment group initially or after 7 days with a reduction of 0.5 ± 0.71 (p = 0.05), but without persistence after 3 months. Conjunctival hyperemia showed a significant reduction in the placebo group after 3 months with a reduction of 0.38 ± 0.77 (p = 0.007), but not in the treated subjects. Lipcof, Schirmer-II-Test, Oxford-Grading-Scale as well as the Meibomian gland dysfunction showed no significant differences in either group. Similarly, the comparison of both groups showed no significant difference between the two subject groups for any of the parameters over the entire follow-up. Conclusion. The Rexon Eye Procedure is a procedure with a tendency to reduce sicca symptoms. A general recommendation for its use cannot be made based on the study results, although individual patients benefited from the treatment.
Hegemoni Ketua Partai Terhadap Presiden dalam Majalah Tempo Edisi 13-19 April 2015 (Studi Analisis Wacana Kritis)
Authors: Hasan Moh Khalid , Wafi Abdul
Published: October 2024

This study aims to describe Jokowi Mega's hegemony based on the discourse dimension (mesostructural) based on the socio-cultural dimension (macrostructural) in the April 13-19, 2015 edition of Tempo magazine. This type of research is qualitative research. This research uses a critical discourse analysis (AWK) approach, according to Darma, the AWK discussion focuses on the nature of ideological contextualization. The approach to ideology must pay attention to its effect on the form and meaning as well as the structure of the discourse which will later play a role in shaping and shaping ideology.  The results of the analysis showed that the April 13-19, 2015, edition of Tempo magazine contained a statement from the party chairman, who wanted the presidential administration to follow the party constitution. The three dimensions are the textual (microstructural) dimension in the magazine studied, using a lot of diction and conjunctions. The discourse dimension (mesostructural) is a journalist's review of the hegemony carried out by Megawati against the President and proves that Tempo Magazine is not affiliated with the government. The practical socio-cultural (macrostructural) dimension, which focuses on political issues contained in Tempo magazine.
Comparative Analysis of Flipped Classroom Implementation in Western and Indian Indoctrination
Authors: Ray Suvendu , Sikdar Deb Prasad
Published: October 2024

The flipped classroom, a popular teaching method in Western countries, has gained popularity due to its ability to address traditional teaching limitations. However, India’s diverse education system presents unique challenges, including technological disparities, traditional practices, and curriculum rigidity. This study aimed to compare the implementation and outcomes of the flipped classroom model in Western countries and India, revealing key factors contributing to its success or challenges. The study aimed to provide insights into how the flipped classroom model can be adapted and optimized to fit different educational environments, ultimately improving learning outcomes and teaching practices globally. The study has explored adopting and implementing the flipped classroom model in Western countries and India, identifying challenges and barriers. It has also evaluated educational outcomes, explored the role of technological infrastructure, assesses teacher readiness and training, and provides explored the role of technological infrastructure, assessed teacher readiness and training, and explored the role of technological infrastructure, assessed teacher readiness and training, and provided recommendations for enhancing its effectiveness in India. The flipped classroom model can enhance educational outcomes by increasing engagement and active learning. However, India faces unique challenges and needs targeted solutions. India should invest in technology, professional development, curriculum adaptation, and community engagement to maximize its benefits.
Oblique versus Straight skin incision: The impact of incision type on postoperative outcomes in distal radiocephalic arteriovenous fistula creation
Authors: Aytekin Bahadir , Kasimzade Ferit
Published: October 2024

Aim: The type of skin incision utilized in arteriovenous (AV) fistula creation may significantly influence the patency, maturation, and overall outcomes of the fistulas. An oblique skin incision may offer distinct advantages in preventing early AV fistula failure by reducing skin tension and minimizing pressure on the newly formed anastomosis. This study aims to compare the postoperative early period outcomes of oblique versus straight skin incision techniques, with a focus on their impact on AV fistula success.
Material and Methods: 2020 to 2023, all patients with created AV fistula via distal antebrachial vessels with oblique and straight skin incisions were enrolled. Retrospectively, the patients’ demographics, comorbidities were collated from the hospital data. All patients were operated with local anesthesia for radiocephalic AV fistula creation. The characteristics of the vessels were determined through preoperative Doppler ultrasonography mapping. Evaluations were conducted on primary patency, early maturation, and the incidence of early thrombosis.
Results: In Total, 182 patients were operated for AV fistula creation. The mean age was 57±17 years and there was a male predominance with %68. We performed 74 patients AVF creation via straight skin incision and 108 via oblique skin incision. Despite there being no differences in comorbidities and demographic characteristics between the two groups, the group with a straight skin incision exhibited a higher incidence of early thrombosis (p=0.03), a lower maturation rate (p=0.03), and reduced primary patency (p=0.01).
Conclusion: Oblique skin incision could be a feasible alternative to conventional straight incision with a higher early AVF patency and lower thrombosis rates. Reducing the pressure on and keeping the incision away from the new anastomosis may be crucial for achieving better outcomes.
Pediatric Post Pubertal Undescended Testicular Torsion
Authors: Cobb William , Xavier Jonathan , Pai Vinay , Gomez Pablo
Published: October 2024

Introduction: Cryptorchidism is defined as a testicle located outside the scrotum. These undescended gonads are often found along the path of testicular descent. Testicular torsion occurs when the spermatic cord rotates upon itself leading to acute decreased or absent blood flow to the testicle. The literature of testicular torsion associated with cryptorchidism in the pediatric population was first described by Delasiauve in 1840 with limited case reports, case series, and small retrospective reviews since then. The actual incidence of testicular torsion with cryptorchidism in post-pubertal pediatric patients remains unknown due to the extremely limited published literature on the topic.

Case Description: Here we present the case of a testicular torsion of an undescended inguinal testicle of a post-pubertal male who presented with three days of worsening right lower quadrant abdominal and right inguinal pain associated with worsening bulging of the right inguinal canal and erythematous changes to the area. Ultrasonography revealed torsion of the right testicle with diffuse abnormally low echotexture, trace hydrocele, overlying scrotal wall thickening with edema, an enlarged right epididymis with heterogenous echotexture, and absent arterial blood flow by Doppler. The patient underwent emergent inguinal exploration, right inguinal orchiectomy, and concomitant scrotal exploration, and left testicular fixation. Pathology was consistent with a diffusely hemorrhagic and infarcted testicle consistent with testicular torsion, negative for malignancy.

Discussion: Further research into presentation, diagnostic acumen, and awareness of this rare but consequential condition is warranted for referring providers and caregivers to decrease devastating results such as testicular necrosis and orchiectomy.
A Rare Case of Verruca Vulgaris Lip and its Surgical Management
Authors: Kumar Naveen
Published: October 2024

Oral verruca vulgaris also known as viral papilloma has been commonly associated with human papillomavirus (HPV) 6 and 11, is a rare lesion. We present a rare case of large sized verruca vulgaris over lower lip mucosa associated with other leukoplakia lesions.
A 60-years-old male patient , a tobacco chewer presented with complaint of growth on lower lip for the last 8 months. On Intra oral examination, a single 5 X 3 cms well defined hyperkeratotic grayish-white lesion was found with multiple long papillary projections on the mucosal surface of lower lip . Histopathological examination was suggestive of Verruca Vulgaris. Surgical excision of the lesion with safe margins was carried out. Reconstruction was done using inferiorly based left sided Nasolabial flap.
Oral Verruca Vulgaris is a rare lesion which requires a timely diagnosis and treatment to provide asthetically and functionally better outcomes.
Modification of cryoprotectants on sperm cryopreservation: A study of embryo development
Authors: Larasati Manggiasih , Lestari Silvia , Pangestu Mulyoto , Hestiantoro Andon , Wasian Gito
Published: October 2024

Objective: This research was conducted to analyze the effect of cryopreservation of sperm using modified cryoprotectants on embryo development through in vitro fertilization (IVF). In this research, three types of cryoprotectant combinations were compared, including Nakagata, modified cryoprotectant, and commercial (Kitazato).
Materials and Methods: Several parameters, namely sperm concentration, motility, morphology, plasma membrane integrity, cryo-survival rate, and viability rate, were measured and compared before vitrification and warming. Embryo development was also observed on the first and third days of development based on the cell number, cell size, and fragmentation rate.
Results: Sperm cryopreservation exhibited a negative influence on embryo quality. Both Nakagata cryoprotectants and modified cryoprotectants attained good-quality embryos. In terms of embryonic development, this research revealed a modified cryoprotectant superior to Nakagata’s cryoprotectant, although Kitazato was superior to the Nakagata cryoprotectant and modified cryoprotectant. Significant differences were found in the three cryoprotectants on observations on day 1 and day 3, all of them with p-value < 0.05.
Conclusion: Modified cryoprotectant was found to be better than Nakagata but less significant than Kitazato in terms of embryonic development quality. Therefore, modified cryoprotectants could be a better alternative compared to commercial (Kitazato) cryoprotectants for improving embryo quality.
The antioxidant, anti-cholangiocarcinoma, and anti-Opisthorchis viverrini activities of ethanolic extract from Antidesma thwaitesianum fruit
Authors: Aukkanimart Ratchadawan , Sriraj Pranee , Changthong Areeya , Promsrisuk Tichanon
Published: October 2024

Objectives: The current study was performed to determine the antioxidant, anti-inflammatory, and anti-cholangiocarcinoma (CCA) properties of Antidesma thwaitesianum, also known as “MAO,” whole plant extract on Opisthorchiasis in animal models and CCA cell lines.
Materials and Methods: Ethanol was used to extract compounds from the whole ripe fruit. The phytochemical investigation of MAO extract was done to evaluate antioxidant activity, and high-performance liquid chromatography was used to identify the active compounds. The efficacy of MAO extract against OV was evaluated in vivo. The anti- CCA activity was evaluated using superoxide dismutase (SRB), cell cycle arrest, apoptosis, and western blot analyses.
Results: MAO extract possessed flavonoid and phenolic contents, antioxidant activity, and an expressed cyanidin-3-O-glycosides content of 0.08 μg/mg extract. MAO extract demonstrated hepatoprotective effects through raised alanine transaminase and alkaline phosphatase levels, as well as an influence on oxidative stress via decreased MDA and increased glutathione, superoxide dismutase, and catalase levels. MAO extract significantly inhibited the migration of CCA cells in a concentration- and time-dependent manner, as well as triggered cell cycle arrest on G1 and activated apoptosis pathways via upregulation of C3, downregulation of cyclin-dependent kinase inhibitor p21, cyclin D, and cyclin-dependent kinases 2 expression. MAO extract inhibited inflammation, which in turn decreased fibrosis in hamsters. It also increased hepatoprotective activity.
Conclusion: Our findings demonstrate the potential benefits of MAO extract in both in vitro and animal studies of hamster opisthorchiasis. However, more research should be done to ascertain the mechanisms of activity of MAO extracts and elute bioactive components in order to confirm their safety and examine their clinical applications.
Rumen-protected lysine and methionine failed to improve the performance of latenursing Awassi ewes regardless of dietary protein contents
Authors: Awawdeh Mofleh
Published: October 2024

Objective: The current study investigated the effects of supplying ruminally protected amino acids (AA) (lysine, L; and methionine, M) and dietary protein levels on the performance of late-nursing ewes.
Materials and Methods: Thirty-one Awassi ewes nursing single lambs were individually housed and assigned randomly to one of four treatment groups (2 × 2 factorial design). Ewes in treatment groups were (with supplemental RPL and RPM) or were not (without supplemental RPL and RPM) supplemented with lysine (8.5 gm/day) and methionine (4 gm/day) and were fed diets containing either 13.2 (moderate protein) or 11.1% (low protein) protein.
Results: No interactions between supplemental AA and dietary protein levels were observed. Supplying ewes with L and M did not affect (p ≥ 0.06) their nutrient intake or their final body weights (BWs). Additionally, milk composition, yield, and efficiency were not affected by supple¬mental L and M. Decreasing dietary protein levels did not affect (p = 0.13) the final BWs, milk yield, composition, and efficiency but decreased (p < 0.01) nutrient intake of ewes.
Conclusion: Under our study conditions, reducing the protein contents of the diets from 13.2% to 11.1% had no negative impact on late-nursing ewes. Regardless of dietary protein level, the beneficial effect of supplying L and M was not evident.
Study of socio-clinical risk factors and assessment of metabolic syndrome and Risk of Cardiovascular Events in Patients With polycystic ovary syndrome
Authors: derouiche samir , Kherraz Malika , Chekima Nour , Allahoum Roufaida
Published: October 2024

Background and Aims: More than 1.55 million women of reproductive age have polycystic ovary syndrome (PCOS) in the world; PCOS is an important disease threatens public health, linked to psychological, metabolic, and reproductive problems. The aim of our work was an evaluation of some risk factors, oxidative stress and Cardiovascular Risk among PCOS Women in El-Oued region. Methods: Our risk factor study was conducted on a group of 200 women who were diagnosed by specialized doctors (100 healthy and 100 polycystic ovaries), with 50 women volunteering to provide blood and saliva samples to study the blood glucose, Atherogenic index, lipids profile, hematological and oxidative stress markers. Results: About risk factors study, our results showed that the high levels of Psychological distress, Menstrual fluctuation and year of taking pills are the most dangerous factors (OR=3.11; OR=9.205; OR=5.940) respectively. Our result demonstrated a significant increase (P > 0.05) in blood glucose, total cholesterol, Triglycerides, VLDL, Atherogenic index and sedimentation rate, MDA and SOD levels and a significant decreased (P > 0.01) in HDL, WBC (P < 0.000), MCV (P < 0.05) HGB, RBC, CMH, CMH level in women with PCOS patients as compared to controls. Conclusions: In conclusion, several social and nutritional factors contributed to the spread and development of PCOS in El-Oued region. In addition to a change in blood components, lipid profile Atherogenic index and their relationship to oxidative stress, which contributes to metabolic syndrome development and the occurrence of cardiovascular complication in women with PCOS.
Phytochemicals, antioxidant and antimicrobial activities of Opuntia stricta fruits peel
Authors: Affi Wissal , Mohamed Abdalla , Gharsallah Neji , Smetanska Iryna , Zourgui Lazhar
Published: October 2024

Background:
Currently, research is focused on therapeutic plants which are regarded as a supply of several phytotherapeutic compounds with several activities; among these plants we find cacti.

Aim:
The purpose of this work is to reveal the phytochemical composition and the antioxidant and antimicrobial properties of fruit peel from Opuntia stricta.

Methods:
The phenolics profile has been obtained by LC-ESI-MS analysis, antioxidant capacity has been evaluated by DPPH, FRAP, CAT, and ABTS• + free radical, the antimicrobial activity was tested against 7 bacteria and 3 fungi.

Results:
The results reveal that EFOS has a high content in polyphenols, flavonoids, quinic acid and hyperoside which were the most dominant. Moreover, the observed antioxidant capacity of extract was remarkable. In addition, a high antimicrobial capacity especially against Staphylococcus aureus and Pythium catenulatum. These results indicate that fruits peels of O. stricta have potential applications as a natural preservative in cosmetics and in food formulations, and also as a natural remedy.

Conclusion:
The finding proved that EFOS is characterized firstly by a wide variability of polyphenols and flavonoids and secondly by a good potential antioxidant and antibacterial activities.
Black soybean extract inhibits rat mammary carcinogenesis through BRCA1 and TNF-α expression: In silico and in vivo study
Authors: Pratama Dyah , Fernanda Annesia , Raissa Ricadonna , Permata Fajar , Nordin Muhammad
Published: October 2024

Background:
Mammary gland carcinoma is a malignant type of cancer that occurs in mammae tissue. Dimethylbenzene (α) anthracene (DMBA) is a carcinogenic agent that causes mammary cancer by damaging cellular DNA. Flavonoids found in the black soybean (Glycine max L. Merr) exhibit anti-carcinogenic effects.

Aim:
This study evaluated the anticarcinogenic effects of black soybean extract.

Methods:
The activity of flavonoid compounds in black soybean was determined in silico. Five groups of rats, four in each group, were established, consisting of a negative control, a positive control, and three treatment groups. Treatment included black soybean extract administration (i.e., T1 = 200, T2 = 400, and T3 = 800 mg of black soybean extract/kg body weight for 10 days). The observed parameters included the immunohistochemical analysis of BRCA1 and TNF-α.

Results:
Based on an in silico study, compounds from black soybeans are non-toxic. Functional annotation analysis revealed that most of the target proteins have a role in biological processes associated with cancer development. An in vivo analysis using an animal mammae cancer model indicated that black soybean extracts inhibited mammae cancer progression by attenuating TNF-α and BRCA1 expression.

Conclusion:
The most effective dosage of black soybean extract was 200 mg/kg body weight. An increase in BRCA1 and TNF-α expression may be related to the effects of catechin, daidzein, genistein, and glycitein, which are present in black soybeans.
Scales in a dog after levothyroxine sodium treatment: A case report
Authors: Kasuga Yoichiro , Murayama Nobuo
Published: October 2024

Background:
Scales are composed of exfoliated keratinocytes and are frequently a secondary change, requiring the determination of the underlying cause. Consequently, making an appropriate differential diagnosis of scales and determining treatment necessity based on the results is crucial in dermatological practice.

Case Description:
We present a 7-year-old, neutered male Toy Poodle examined at Myogadani Animal Hospital with chief complaints of exercise intolerance, unexplained weight gain, and dermatological signs, including symmetrical alopecia of the trunk. The dog was diagnosed with hypothyroidism and administered levothyroxine sodium. A significant number of scales were observed, primarily on the trunk, after one month of administration. The scales disappeared after only reducing the dose of levothyroxine sodium for three months. Additionally, hair regrowth was observed as the scales disappeared. In this case, the scales were primarily observed in the alopecia area of the trunk, where hair growth was subsequently noted. Hence, levothyroxine sodium administration was thought to not only facilitate hair regrowth but also influence skin turnover, causing the appearance of scales.

Conclusion:
Clinicians who treat hypothyroidism need to be cognizant that symmetrical scales, primarily located on the trunk, do not co-occur with other skin lesions, such as erythema, and are not itchy, may appear within a month. The scales will naturally disappear in such cases when hair growth is complete; thus, no additional treatment is required.
A case of primary pulmonary paraganglioma in a dog
Authors: Goda Yoshimichi , Mizutani Shinya , Akashi Natsuki , Kanda Teppei , Kutara Kenji , Okamura Yasuhiko , Asanuma Taketoshi
Published: October 2024

Background:
Lung tumors in dogs, significantly primary paragangliomas, are rare and have not been reported. This report describes a dog with a lung tumor diagnosed as a primary paraganglioma.

Case Description:
A 12-year-old spayed French bulldog presented with a left-sided pulmonary mass. The dog was in good general condition and had no clinical symptoms. Computed tomography (CT) revealed a pulmonary mass near the bifurcation of the posterior lobe bronchus of the left lung. The mass showed a strong contrast enhancement effect that was subsequently attenuated. The dog underwent Surgery to remove the mass from the left lung. Abnormal hypertension was observed during surgery, and hypertensive crisis was suspected. Based on the histopathology and preoperative and postoperative urinary metanephrine and normetanephrine levels, the dog was diagnosed with primary paraganglioma of the lung. Although the CT scan showed findings suggestive of the development of a neuroendocrine tumor, it was difficult to suspect the development of a paraganglioma.

Conclusion:
The possibility of catecholamine-producing tumors should be considered when we encounter a lung tumor with no clinical symptoms and a neuroendocrine tumor like contrast enhancement pattern on CT scan.
The application of pheromones extracted from Shami goats' male hair and Awassi sheep male wool during the breeding season on LH and Progesterone concentrations in Awassi ewes in Syria
Authors: Harba Hasan , Moussa Mohamad , AlYasin Abdel , Zarkawi Moataz , Amirat Lamia
Published: October 2024

Background:
The efficiency and profitability of animal farming systems are closely linked to the reproductive success of livestock, which requires effective management through biological, hormonal, and nutritional strategies. The “male effect,” referring to the influence of male pheromones on female reproductive hormones, offers several benefits. This leads to improved reproductive management, better timing of breeding, and increased fertility rates. Additionally, using natural pheromones provides a non-invasive and sustainable method for managing reproduction, and it can be a cost-effective strategy, reducing the need for expensive hormonal treatments. Incorporating male pheromones into reproductive management practices can thus boost the efficiency and profitability of animal farming systems.

Aim:
The study’s objective is to examine the influence of pheromones, extracted from Awassi ram’s wool and Shami goat buck’s hair, on the secretion of luteinizing hormone (LH) and Progesterone (P4) in Awassi ewes during the breeding season.

Methods:
The pheromones were extracted using a soaking method with dichloromethane as the solvent. The resulting organic extract was then analyzed using a Chromatec-Crystal 5000 gas chromatography-mass spectrometry device, equipped with a quadrupole mass spectrometer. The experiment was carried out on three equal groups, each consisting of 17 subjects, during the breeding season. In Group I, 15 ml of the ram’s wool extract was applied to a piece of gauze and placed in a specially designed mask that was attached directly to the nose. In the second group, a similar procedure was followed using 15 ml of the buck’s hair extract. The third group consisted of Awassi rams. The LH assay was conducted immediately before the treatment and again at 1-, 10-, 20-hours post-treatment and after 5 and 30 days of treatment to assess progesterone levels.

Results:
The study found that pheromones from Awassi rams and Shami goat bucks significantly increased the levels of luteinizing hormone (LH) and the Progesterone (P4) in female Awassi sheep.

Conclusion:
The study concludes that the pheromones extracted from the wool of rams and Shami goat bucks can stimulate the response of female Awassi sheep. This finding opens up the possibility of using these pheromones in the reproductive management of female Awassi sheep.
Zinc-based fixative as a novel approach for histological preservation: A comparative study with formalin-based fixatives
Authors: Altaey Omar , Hasan Ali , Hasso Adnan
Published: October 2024

Background:
Formalin is a widely used histological fixative despite its carcinogenic properties, inadequate nucleic acids preservation, and prolonged fixation time.

Aim:
The study intended to prepare a novel zinc-based fixative which is, formalin-free, and cost-effective, provide optimal preservation, with rapid penetration rates, and enhanced Hematoxylin/Eosin-stained sections.

Methods:
Liver, kidney, brain, and small intestine specimens were collected from ten adult laboratory rats (Rattus norvegicus) and preserved in formalin 4%, formalin 10%, NBF and the experimental EZAT solution. The penetration depth (discolored edges) was measured at 6, 12, 24, and 48-hours. The shrinkage ratio was calculated by measuring the width and length of the samples before and after 48 hours of fixation. The histological evaluation, included staining affinity, cellular outline, cytoplasmic and nuclear attributes, and overall tissue structure, was conducted by a panel of academic experts and rated using a scale of poor (1), fair (2), good (3), very good (4), and excellent (5) grades. The data were later statistically analyzed to determine the significant differences among the tested fixative types.

Results:
Higher penetration rate was observed with the EZAT solution at 6 and 12 hours’ time and the samples were reached at optimal fixation after 24 hours; with an accelerated diffusion coefficient, and a minimal shrinking effect compared to formalin 10% and NBF. The microscopic evaluation of Hematoxylin/Eosin-stained sections revealed better staining affinity, refined histological details, and enhanced cytoplasmic and nuclear properties. The overall structural evaluation revealed an excellent microscopic appearance with the EZAT solution compared to formalin-based fixatives.

Conclusion:
The EZAT fixative should be considered as an everyday preservative in histology and histopathology laboratories. Future studies should be focused on the potential of EZAT in cellular histochemistry and immunohistochemistry practices.
ÇOCUKLARDA TEKNOLOJİNİN GETİRDİĞİ RİSKLERDEN KAÇINMA VE BİLİNÇLİ İNTERNET KULLANIMINI DESTEKLEYEN ÇALIŞMALAR
Authors: Çamalan Veli Furkan , Demirbaş Elif
Published: October 2024

Günümüzde teknoloji, insan hayatında önemli bir rol oynamaktadır. Eğitimden sağlığa kadar birçok alanda büyük kolaylık sağlayan teknoloji, özellikle boş zaman etkinlikleriyle hayatımızın büyük bir kısmını doldurmaktadır. Çocukların günlük yaşamlarının önemli bir kısmını teknolojiyle geçirdikleri bilinmektedir. Bu çalışmanın amacı, aşırı teknoloji kullanımının çocuklar için olası risklerinin neler olduğunu, eğitimde teknolojinin etkili bir şekilde nasıl kullanılabileceğini ortaya koymak ve bu kapsamda çocukların teknolojiyi bilinçli kullanmalarını destekleyen çalışmaları incelemektir. Araştırma, son 10 yıl içinde çocukların dijital dünyayla etkileşimini yönlendirmeye yönelik geliştirilen stratejileri inceleyen literatür taraması yöntemiyle gerçekleştirilmiştir. Ele alınan stratejiler arasında eğitim uygulamaları, interaktif öğrenme platformları, dijital medya kullanımına yönelik rehberlik yönergeleri ve sosyal hizmet uzmanlarının bağımlılık sorunlarına dair müdahaleleri yer almaktadır. Ebeveynler ve öğretmenlerin çocukları güvenli ve bilinçli teknoloji kullanımına yönlendirmede dijital okuryazarlık, çevrimiçi güvenlik ve ekran süresi yönetimi gibi konulara odaklanmasının etkili sonuçlar verdiği görülmektedir.