bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the Synergy Effect of Leisure Agriculture and Rural Tourism Development
Authors: Zhou Caifeng
Published: October 2024

In recent years, with the rapid development of the social economy, the market demand for tourism has subsequently enhanced, the integration of leisure agriculture and rural tourism as a new type of business, the state-issued policy support, leisure agriculture and rural tourism has also received widespread attention. This study proceeds to the demand for the synergistic development of leisure agriculture and rural tourism, reveals the mechanism of synergistic development of leisure agriculture and rural tourism, plans its development trend then constructs a coupling evaluation model for the synergistic development of leisure agriculture and rural tourism by using entropy method, entropy weight method and coupling model. Finally, through empirical analysis, it is concluded that both leisure agriculture and rural tourism in province M as a whole show a certain upward trend, and, in 2021~2023, both of them stepped from the state of dysfunction into the state of primary coordination, and the degree of coupling coordination was raised from 0.6251 to 0.6421. During 2019~2020, the degree of coupling coordination between leisure agriculture and rural tourism is constantly climbing, the coupling coordination relationship between leisure agriculture and rural tourism coupling coordination relationship is continuously strengthening, and the cooperation between industries is gradually increasing. Secondly, the driving force of leisure agriculture as a whole has become a rising trend, while the tourism industry is generally stabilizing. The unbalanced development of tourism’s three-dimensional power has a certain inhibiting effect.
A responsabilidade civil do responsável pelo tratamento de dados por facto do subcontratante
Authors: Menezes Ricardo
Published: October 2024

O presente estudo tem por objeto a análise do regime aplicável à responsabilidade civil do responsável pelo tratamento de dados pessoais perante terceiros por facto imputável ao subcontratante, à luz do disposto no Regulamento Geral sobre a Proteção de Dados (doravante “RGPD”). No que respeita à responsabilidade extracontratual, concluímos ser mais correta a posição dos autores que entendem que o RGPD consagra um modelo de responsabilidade civil objetiva. Neste âmbito, parte da doutrina tem defendido a aplicação do regime da responsabilidade civil do comitente pelos danos causados pelo comissário (art. 500.o do Código Civil). Quanto aos casos em que as operações de tratamento de dados se realizem no quadro de uma relação obrigacional, também tem sido equacionada a aplicação da solução acolhida pelo art. 800.o do Código Civil. Concluímos, no entanto, que a aplicação dos regimes previstos nas normas legais referidas depende da verificação de pressupostos mais exigentes que aqueles que consideramos estarem previstos no RGPD, pelo que aderimos à posição dos autores que defendem a não aplicação destes regimes da lei portuguesa a operações de tratamento de dados.
Book review of Moisés Barrio Andrés (dir.): “El Reglamento Europeo de Inteligencia Artificial”, Valencia, Editorial Tirant lo Blanch, 2024, pp. 220, ISBN Paper: 9788410713031, ISBN Ebook: 9788410713048
Authors: Kubica Maria Lubomira
Published: October 2024

Book review of Moisés Barrio Andrés (dir.): “El Reglamento Europeo de Inteligencia Artificial”, Valencia, Editorial Tirant lo Blanch, 2024, pp. 220, ISBN Paper: 9788410713031, ISBN Ebook: 9788410713048
Comparison of Compression of Occlusal Splint Materials: Laboratory Mechanical Analysis
Authors: Gonçalves Victor Paes Dias , Lopes Felipe Perissé Duarte , Vieira Carlos Mauricio Fontes , Lopera Henry Alonso Colorado
Published: October 2024

Objective: To perform a compression test to fill the gap in the literature, assess the change in the construction angle (0º, 45º, 90º) as well as investigate physical and microstructural characteristics.
 
Theoretical Framework: Comparisons of compression tests of occlusal splint materials printed in 3D are not described in the literature, which makes informed decision making on the choice of materials complicated.
 
Method: The materials printed in 3D using the SLA method were resins. After printing, the materials were submitted to compression (calculating the Poisson coefficient), shore hardness and density tests.
 
Results and Discussion: Dima® Print Ortho achieved the best results in terms of compression strength and maximum deformation in the vertical position (90º) in comparison to the other materials, followed by Self BioPrint Splint Hard, PriZma 3D Bio Splint and Cosmos Splint.
 
Research Implications: Three-dimensional devices through additive fabrication can be used in the treatment of bruxism. The position to obtain greater compression strength is vertically at 90º.
 
Originality/Value: This study contributes to the literature by demonstrating the efficacy of 3D printing of occlusal devices using the resin polymerization method, highlighting the superior dimensional accuracy and mechanical properties of the materials employed. Furthermore, it addresses the sustainability of the process by promoting material waste reduction during fabrication. These findings have significant implications for optimizing the production of occlusal devices in clinical settings.
Atherosclerotic renovascular disease: pathogenesis, clinical manifestations, diagnosis, treatment. Literature review
Authors: Baranova E. I. , Kolesnik O. S. , Kolesnik O. S.
Published: October 2024

The literature review is devoted to one of the most common secondary forms of arterial hypertension – renovascular hypertension of atherosclerotic genesis. The review examines the prevalence of this problem, pathogenetic mechanisms, risk factors and clinical manifestations. Special attention should be paid to the problem of combining renovascular arterial hypertension with renal dysfunction and with manifestations of heart failure, which is most typical for bilateral hemodynamically significant stenoses or significant stenosis of a single functioning kidney, and allows us to formulate an idea of atherosclerotic renovascular disease. The review contains modern ideas about the diagnosis of this disease and the tactics of managing patients with this pathology. Special attention should be paid to indications for revascularization and ways to restore blood flow through the renal arteries. The review discusses in detail the problems of patient management after interventional treatment and the prognosis of patients with atherosclerotic renovascular disease.
Diagnosis of wild-type transthyretin amyloid cardiomyopathy by primary care physicians in Saint Petersburg. Literature review and clinical case
Authors: Ligidov M. L. , Krutikov A. N. , Poliakova A. А. , Ageeva V. V. , Lapekin S. V. , Amelin A. V. , Andreeva S. E. , Shavlovsky M. M. , Gudkova A. Ya.
Published: October 2024

Cardiac age-related transthyretin amyloidosis is an underdiagnosed reason of heart failure with preserved ejection fraction, the most frequent form of heart failure. We present a clinical case of detection of transthyretin amyloidosis of the heart at stage I-II of the disease based on biomarkers, which made it possible to send the patient to a third-level hospital and achieve the maximum possible compensation for the disease. Based on this case report, we review modern algorithms allowing to suspect and make the diagnosis, from performing routine tests like ECG and echocardiography to more sophisticated instruments like 2D strain-echocardiography, radiology and endomyocardial biopsy. Also staging systems using biomarkers for cardiac transthyretin amyloidosis are discussed. We consider possible paths to early diagnosis of this disease and nuances of medical therapy.
Repeat revascularization after acute coronary syndrome: risk factors and potential targets for therapeutic intervention
Authors: Trusov I. S. , Nifontov E. M.
Published: October 2024

Acute coronary syndrome (ACS) is a life-threatening condition, for the treatment of which modern methods of myocardial revascularization are used, but in the long-term follow-up period, coronary artery restenosis often occurs, which requires re-intervention. There are many factors that influence the risk of developing long-term complications. Moreover, most of them, such as age, heredity, anatomical features of damage to the coronary arteries, are non-modifiable. At the same time, there are a number of indicators that influence the likelihood of developing restenosis, which can become a potential target for therapeutic intervention. The search for predictors of lumen loss in stented arteries is an urgent problem.
High-grade second-degree atrioventricular block associated with obstructive sleep apnea syndrome (experience in the effective use of respiratory support)
Authors: Ionin V. A. , Berdysheva V. A. , Vakulenko A. S. , Baranova E. I.
Published: October 2024

Sleep-disordered breathing and nighttime bradyarrhythmias associated with this syndrome are often encountered in clinical practice. With high-grade atrioventricular blocks, such patients are usually implanted with a permanent pacemaker, but this treatment method is not indicated for patients with reversible conduction disorders. A clinical case of the successful use of CPAP therapy in a patient with second degree atrioventricular block at night associated with obstructive sleep apnea syndrome is presented. Approaches to the diagnosis and treatment of patients with bradyarrhythmias are discussed.
MEMPERLUAS KEMAMPUAN ALAT PENCABUT SINGKONG: PENGEMBANGAN LEBIH LANJUT UNTUK KEBUTUHAN PETANI
Authors: Sundari Susanti , Pratama Aam Wahyu , Suharto  , Hidayat Ghapur
Published: October 2024

This research builds upon the author's earlier work on the design of a cassava pulling tool. The aim is to develop a non-mechanical or minimally-powered tool that addresses farmer needs. The tool design incorporates Quality Function Deployment (QFD) to ensure user satisfaction.  QFD is a method that integrates customer desires into technical requirements during the design phase, prior to production. Data analysis revealed key user desires: lightweight materials, affordability, the ability to pull multiple cassava stems simultaneously, durability, safety, and additional functionalities. House of Quality (HOQ) analysis identified the most crucial attribute (weight of importance: 30%) as the ability to pull multiple stems at once. This finding served as the primary basis for prototype development and technical characteristic definition. Subsequent prototype testing successfully uprooted cassava plants, demonstrating the tool's capability of pulling multiple stems in a single operation.
PENERAPAN CRITICAL PATH METHOD DALAM PENJADWALAN PROYEK PEMASANGAN TANGKI STORAGE ST-1812, STUDI KASUS PADA PT. MSM
Authors: Nugraha Dwi Noviarsi Patria , Titisari Manik Ayu
Published: October 2024

The installation of the ST-1812 storage tank aims to improve production efficiency at PT. MSM by saving costs in the use of steam from 16 hours to only 4 hours, which is used to heat the final product to temperature of 63°C according to work instructions. Critical Path Method is used to determine the optimal construction time, because this method can identify the sequence of tasks that are most critical or that have the most impact on the duration of the entire project. The purpose of this study is to determine the optimal duration for implementation and completion of the ST-1812 storage tank installation project at PT MSM. The analysis of the CPM application showed that the project took 90 days to complete, with 19 activities included in the critical path. The addition of working hours (overtime) on activities on the critical path makes the project can be completed in 73 days, 17 days faster than the initial duration of the project. The initial cost of the project was IDR 66,555,000, and the cost after accelerating the project with crashing calculations was IDR 74,886,429, with a cost slope of IDR 8,331,429.
Perceived Risk And Self Efficacy Effect On Digital Gold Applications Usage
Authors: Taufan Adi Kurniawan  , Anita Primastiwi  , Devy Putri Milanda
Published: October 2024

Gold prices in the last quarter of 2022 to March 2023 have increased significantly. This was caused by several reasons, such as war and two large banks' bankruptcies, namely Silicon Valley Bank and Signature Bank; many investors have switched to gold investment. Indonesians are used to gold investment; various Fintech applications have provided digital gold investment, and the government also has regulations for digital gold investments, but Indonesians still hesitate to use digital gold for investment. This study aims to analyse the effect of some factors on digital gold applications using the Technology Acceptance Model (TAM) and adding external variables such as perceived risk and self-efficacy. The results showed that all TAM variables had a positive effect, and self-efficacy and perceived risk variables also had a positive effect. This means digital gold application users in Indonesia are still affected by perceived ease of use, perceived usefulness, perceived risk of applications and self-efficacy in using digital gold applications.
Editorial
Authors: Dieter Wilfried
Published: October 2024

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Die metaphorische und narrative Dimension der Katathym Imaginativen Psychotherapie (KIP)
Authors: Ullmann Harald
Published: October 2024

Die Katathym Imaginative Psychotherapie (KIP) stützt sich von Anfang an auf dramatische Spannungslinien und metaphorische Strukturen. Sie reichen vom Symbol bis zu seiner Entfaltung in der Interaktion und von der Motivgestaltung bis zur Gestaltung des therapeutischen Prozesses. Dabei greifen symbolische, dramatische und metaphorische Elemente ineinander, die unter entwicklungspsychologischen, neurobiologischen und psychodynamischen Gesichtspunkten zu betrachten sind. Sie alle bündeln sich auf der Ebene des Tagtraumgeschehens in der Trias Vergegenwärtigen – Episodenaktivierung – Rekontextualisierung, komplettiert durch den Vorgang der Konsolidierung über Wiederholungsschleifen. Für einen kreativen Umgang mit dem agierenden Moment des Verfahrens sollte künftig neben klassischen klinischen Konzepten, die auf die Notwendigkeit des Durcharbeitens von Übertragungswiderständen und Wiederholungszwang abheben, zunehmend auch ein Vorgehen praktiziert werden, das vom episodischen Vergegenwärtigen zum Ausprobieren und wiederholten Durchspielen neuer Options- und Handlungsweisen führt. Der diesbezügliche, als narrative Dimension bekannt gewordene Verständnisrahmen ist im Sinne einer metaphorisch-narrativen Dimension zu erweitern.
Übertragung und Gegenübertragung sind Saiten eines Instruments
Authors: Dieter Wilfried
Published: October 2024

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Inhalt
Authors: Imagination
Published: October 2024

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Novel Insights Into The Role Of Serum Interleukin-39 In Patients With Systemic Lupus Erythematosus
Authors: Al Rubaye Amal Mahdi , Sharquie Inas K. , Gorial Faiq I.
Published: October 2024

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that has a genetic predisposition and a complex pathogenesis in which the involvement of various cytokines has been shown. In the current study, serum interleukin-39 (IL-39) levels from 99 patients with SLE and 33 healthy control subjects who attended the Baghdad Teaching Hospital Rheumatology Unit were examined. Patients were divided into 3 subgroups according to disease status: inactive (n = 33), active moderate (n = 33), and active severe (n = 33). This topic has not yet been explored, so the significance of IL-39 as a biomarker for SLE was evaluated. Cytokine levels were measured using enzyme-linked immunosorbent assay kits. Full medical histories, body mass index, gender, and clinical disease activity, the latter evaluated using the SLE disease activity index, were documented. Laboratory disease parameters, including anti-dsDNA antibodies, C3 and C4 levels, erythrocyte sedimentation rate, and C-reactive protein titres, were measured. The mean age of patients was 33.92 ± 0.91 years. The IL-39 level was higher in patients (13.70 ± 0.35 ng/l) than in controls (10.67 ± 0.19 ng/l, p < 0.01). The mean of IL-39 levels was highest in patients with active severe SLE (17.42 ± 0.48 ng/l) and then became incrementally lower with reducing disease severity, i.e., active moderate, 13.34 ± 0.23 ng/l; inactive, 10.93 ± 0.24 ng/l. Serum IL-39 showed good validity for the diagnosis of SLE. With a cut-off value ≥ 10.25 ng/l and an area under the curve of 0.79, diagnostic sensitivity, accuracy, and specificity were 79.98%, 51.5%, and 71.97%, respectively. In conclusion, serum IL-39 levels were significantly higher in patients with SLE than in healthy controls and were correlated with disease activity. This interleukin may be useful in predicting disease severity.
Multiple Upward Residual Gravity and Magnetic Maps to Estimate the Deep Crustal Layers and Moho Discontinuity in Eastern Iraq
Authors: Al-Banna Ahmed Sh. , Majeed Hayder H.
Published: October 2024

The upward continuation technique was applied to the gravity and magnetic data to obtain the residual anomalies maps in eastern Iraq. A new processing method is introduced to calculate the crustal layers depending on the relation between the total range of the residual anomalies of gravity, magnetic data and the upward continuation, with multi-elevations. The significant relationship shows slope variations, which may reflect the maximum contrast in the physical properties (density and/or susceptibility) and the intersection point representing the depth of layer contacts. This method was applied to the eastern central part of Iraq, adjacent to the Iranian borders. It is found that the average depth range to the Jurassic formations, top basement rocks, transition layer (Curie point), and Moho discontinuity are   3.1- 4.8 km, 8-12.9 km, 20.9-22.4 km and 43.6 km, respectively. The Sedimentary cover in the study area ranges from 8 to 13 km. The maximum depth to the Moho discontinuity obtained by gravity data in the study area is 43.6 km. The radially average power spectrum technique was applied in the study area to calculate the gravity depth and magnetic sources' depth. Three depth levels of sources from gravity and magnetic data were obtained. These depths are shallow sources, average basement rock and deep sources (Moho) at 3km, 13.2-12.1 km, and 32.2-34km, respectively. The obtained results concerning the main layers in the crust were compared between the two methods, and the new method shows more reliable results. The detected depth levels refer to top Jurassic, basement rocks, and Moho discontinuity. The new method is believed to be used to detect the crustal layers depth with good results.
Supplement Continuous and Quasi-Supplement Continuous Modules
Authors: Ali Sarah Hassan , Nayef Mahdi Saleh
Published: October 2024

In this research, we introduce the concepts of -module where (i=1,2,3), as proper generalizations of -conditions, where (i=1,2,3). The relationships between these concepts and previous ones were explained, and a comprehensive description of each was provided. Additionally, by relying on -module, new concepts were developed, such as supplement continuous and quasi-supplement continuous, which represent generalizations of continuous and quasi-continuous. Illustrative examples were provided, and the possibility of their inheritance was discussed.
Centralizers and Double Centralizers for Prime and Semiprime -rings
Authors: Khuder Aya Hussein , Majeed Abdulrahman H.
Published: October 2024

The purpose of this paper is to discuss the centralizers and the double centralizers in prime and semiprime rings with fulfilling certain identities.
Determining the Relationship between the Crescent Visibility Factors and the Coordinates of the Sun and Moon
Authors: Taher Mohammed Y. , Abdulla Fouad M.
Published: October 2024

The study of the relationship between the coordinates of the sun and the moon with the crescent visibility factors has not been previously treated in a detailed and accurate way in  research and previous studies, despite its religious importance. Accordingly, this paper aims to study the relationship between the crescent visibility factors (age, lag time, elongation (ARCL), arc of vision or relative altitude (ARCV), relative azimuth (DAZ), and crescent width (W), with coordinates of the sun and the moon), and how it varies during the day of the crescent's observation. In this paper, Matlab programs were designed to calculate the ecliptic sun and moon coordinates (λ, β) and in the presence of all perturbation impacts (planets), then convert these coordinates to the equatorial (α, δ) and horizontal coordinates (A, a). The results were compared with other programs in this field and references such as the ephemeris, accurate times, and astronomical programs. The variation of the sun and moon coordinates (ecliptic, equatorial, and horizontal) was studied with time, and the relationship of those coordinates was explained with visibility crescent factors during the day of the crescent's observation. Finally, the relationship of those factors with each other was studied. The results indicated that there was a relationship between the sun and the moon coordinates with some factors of crescent visibility in critical and standard observations, where the critical observations of the moon (age, lag time, elongation) were increased when the sun and the moon coordinates approach from two equinox points (spring and autumn), while the other factors, such as the relative azimuth and relative altitude, were independent on the change of the coordinates through the year. Also, a relationship was found between the visibility factors with each other, this led to a direct relationship between increasing the elongation with the crescent width. The values of the relative altitude were also increased with the increase in the lag time. Lastly, there was a direct relationship between the increase in the relative azimuth and the relative altitude.
The Morphometric and Hydrological Analysis of the Largest Valley Basin in the Western Plateau of Iraq
Authors: Mohammed Maryam J. , Jawad Laith A.
Published: October 2024

The study was carried out to see whether it would be possible to use remote sensing and Geographic Information System (GIS) to create a morphometric geodatabase for the largest valley basin in the western Plateau (Houran Valley), Iraq. ArcGIS V.10.8 measured morphological or hydrological features using a digital elevation model (DEM). These properties are considered a crucial database for planning for dry or wet river basins and valleys, saving time, money, and resources compared to extensive regional research. A quantitative investigation of the morphological characteristics determined that the longitudinal drain density was 0.1698 km/Km2, indicative of both high soil permeability and an arid to semi-arid desert environment. The basin is in an early geomorphological stage, and the linear structures determined the design of its drainage network according to the circulation ratio of 0.08566. area's geological structure has considerable changes in hardness, as indicated by the elongation ratio of 0.112, which would facilitate the use of water in the process of the area's sustainable development.
Evaluación del podcast como género discursivo en ELE
Authors: Pasuy Guerrero Gladys Yolanda , Cifuentes Osorio Santiago
Published: October 2024

Resumen
Este artículo se deriva de una investigación cuyo objetivo fue desarrollar competencias orales en los estudiantes de ELE. Se propone al podcast como herramienta didáctica; se aborda como género discursivo y se propone una estrategia de evaluación. En principio, se describen las características, funcionamiento, tipos, producción e implementación del podcast, se aborda el tema de la evaluación de la oralidad y se propone una rúbrica para evaluar la competencia oral en la producción del podcast. La investigación-acción es el enfoque elegido y permitió evidenciar que el aprendizaje es una concertación de acuerdos entre profesor y aprendientes y que cuando estos últimos tienen un papel activo su aprendizaje es significativo.
Assistência de enfermagem aos pais de recém-nascidos prematuros
Authors: Oliveira Amanda Barbosa de , Jacinto Natália Maciel , Moreira Dênis da Silva , Godinho Mônica La Salette da Costa , Silva Tatiana Corrêa da , Felipe Adriana Olímpia Barbosa , Bressan Vânia Regina
Published: October 2024

Objetivo: Identificar na literatura científica evidências disponíveis sobre assistência ou cuidados de enfermagem aos pais de recém-nascidos prematuros. Métodos: Trata-se de uma revisão integrativa com artigos publicados entre 2011 a 2022, no idioma português, inglês ou espanhol e com texto completo disponível. Utilizou como questão norteadora: Quais as evidências disponíveis da literatura sobre a assistência ou cuidados de enfermagem aos pais de recém-nascidos prematuros? A pesquisa bibliográfica foi realizada em janeiro de 2023, nas bases de dados: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), National Library of Medicine National Institutes of Health (PubMed) e Cumulative Index to Nursing and Allied Health Literature (CINAHL), por meio dos Descritores em Ciências da Saúde (DeCS): Recém-nascido prematuro, Cuidados de Enfermagem, Pais, Mães, foram combinados aos operadores booleanos “AND” e “OR”. Resultados: 6 artigos obedeceram aos critérios de inclusão e exclusão, foram separados em três temáticas distintas: Tecnologias educacionais como instrumento de aprendizagem; Desenvolvimento de autonomia e segurança às famílias frente aos cuidados no ambiente hospitalar e domiciliar; Promoção de redes de apoio por meio da visita domiciliar. Considerações finais: Foi possível identificar diversas estratégias utilizadas pelos profissionais de enfermagem, sendo consideradas eficazes para a promoção da assistência.
Perfil epidemiológico da leishmaniose tegumentar e visceral em São Domingos do Capim, Pará, no período de 2015 a 2022
Authors: Silva Leidiane Araújo , Palheta Ananda do Socorro Espíndola , Queiroz Matheus de Oliveira , Silva Marília Pereira da , Silva Kathleen Sousa , Costa Maria Paula dos Santos Sousa Bulhões , Paixão Irlan Menezes da , Oliveira Italo Azevedo , Oliveira Euzebio de , Naka Karytta Sousa
Published: October 2024

Objetivo: Analisar o perfil epidemiológico da Leishmaniose tegumentar e visceral no período de 2015 a 2022, no município de São Domingos do Capim. Métodos: Trata-se de um estudo ecológico, descritivo e retrospectivo dos casos de LT e LV no município de São Domingos do Capim, Pará, região Norte do Brasil, notificados de forma compulsória através do Sistema de Informação de Agravos de Notificação (SINAN). Foi utilizada como ferramenta a Mineração de Dados e tabulações de dados em Excel. Resultados: Foram notificados 23.763 casos de LT e 2.727 casos de LV no estado do Pará, enquanto no município de São domingos do Capim houve 16 casos de LT, recorrente no sexo masculino, faixa etária de 35-49 anos, com ensino fundamental incompleto e que tinham como ocupação produtor agrícola polivalente. Em relação a LV, foi observado 37 casos, mais recorrente no sexo masculino, faixa etária < 10 anos, nível de escolaridade sem informação e que tem os estudos como ocupação. Conclusão: A Leishmaniose é influenciada pela antropização, fatores socioeconômicos, culturais e ambientais, representando uma ameaça social e um problema de saúde pública.
Fatores preditivos associados ao êxito na cirurgia de varicocele para a infertilidade
Authors: Bernardo Rogério César Correia , Medeiros Mércia Lamenha , Machado Aydano Pamponet , Oliveira Michelle Jacintha Cavalcante , Bernardo Thaís Honório Lins
Published: October 2024

Objetivo: Identificar na literatura científica fatores preditivos associados ao êxito na cirurgia de varicocele para infertilidade. Métodos: Revisão integrativa, com artigos publicados entre 2019 a 2023, nos idiomas português, inglês e espanhol e texto completo disponível. Utilizou-se como questão norteadora: Quais são os fatores preditivos associados ao êxito na cirurgia de varicocele para a infertilidade? A pesquisa bibliográfica foi realizada em novembro de 2023 nas bases de dados: Pubmed, Biblioteca Virtual em Saúde, Scielo e Science Direct, por meio dos Descritores em Ciências da Saúde: Varicocele, Infertilidade, Inteligência Artificial e preditores, realizando combinações com os termos com o uso do operador booleano “AND”. Resultados: 27 artigos obedeceram aos critérios de inclusão e exclusão, nos quais 06 artigos na Science Direct, 14 na Pubmed, e 07 na Biblioteca Virtual em Saúde. Em relação ao  tipo de estudo, 9 foram coorte, 6 de revisão, 2 prospectivos, 3 retrospectivos, 2 ensaios clínicos, 3 de intervenção, 1 experimental e 2 observacionais. Considerações finais: Considera-se que alguns fatores podem ser preditores de êxito na cirurgia de varicocele. Entre eles estão parâmetros hormonais, presença de refluxo ao ultrassom, técnica cirúrgica e aspectos no espermograma pré-operatório, normogramas, aprendizagem de máquina e modelagem foram alguns métodos utilizados pelos autores.
Integração ensino-serviço como promotora de cuidados à saúde do homem na região Xingu, Pará
Authors: Barboza Bruno Ricardo Leite , Silva Caio Vinícius Soares da , Lucena Gabriele Lima de , Souza Emanuele Abenassif de , Campelo Marcelo Monteiro , Santos Curuaia Victor Matheus Aranha Monteiro dos , Meireles Tonete dos Santos , Cavalcante Rosiane Luz , Farias Ilka Lorena de Oliveira , Leite Jordy Alexandro Umbuzeiro
Published: October 2024

Objetivo: Relatar a experiência de uma ação promovida por acadêmicos de uma escola médica na promoção da saúde do homem em uma Unidade Básica de Saúde em um município na Região Xingu. Relato de experiência: A ação teve como premissa captar homens acima de dezoito anos de idade para usufruírem de serviços básicos oferecidos pela Unidade de Saúde da Família, além de construir um momento de educação em saúde sobre a primordialidade da adesão do homem a esses cuidados no cotidiano. Foram organizadas três estações para que os homens, após concordarem em participar, entrassem e fossem atendidos pelos discentes envolvidos. Tais locais ofereciam serviços como aferição de pressão arterial e de medidas antropométricas, para verificação de risco cardiovascular, bem como realização de testes rápidos, com o fito de rastrear possíveis Infecções Sexualmente Transmissíveis. Os alunos também realizavam perguntas sobre o histórico clínico do indivíduo, além de orientarem sobre os cuidados em saúde, apoiados por um panfleto desenvolvido pelo grupo. Considerações finais: A ação proporcionou à comunidade local um estímulo ao acompanhamento da saúde individual, além de trazer aos acadêmicos uma experiência como protagonistas na condução do evento em questão, exercitando habilidades técnicas e de comunicação.
A unique case of Sylvian arachnoid cyst complicated by chronic subdural hematoma
Authors: Asagiri Hana , Tsutsumi Satoshi , Izumi Hiroshi , Inami Kasumi , Yamataka Motoki , Sugiyama Natsuki , Ueno Hideaki , Ishii Hisato
Published: October 2024

Background:

Arachnoid cysts (ACs) complicated by chronic subdural hematoma (CSDH) are a rare but distinct entity.

Case Description:

A 27-year-old man previously diagnosed with Sylvian AC presented to the hospital with a persistent headache. He was not aware of any preceding head trauma. However, he frequently performed bench presses at the gymnasium, especially 4 weeks prior. The patient did not exhibit any neurological deficits at presentation. Computed tomography revealed slightly low-density areas in the right cerebral convexity. Magnetic resonance imaging revealed compressive masses in the right middle fossa and cerebral convexity. The patient underwent a craniotomy. Reflection of the dura mater exposed thickened arachnoid membrane. Making an incision resulted in the egress of fluid hematoma. The membrane separating the subdural hematoma and inner AC possessed fine vasculature and adjacent holes. Furthermore, there were fragile clots adhered to the inner wall of the cyst. Microscopic findings of the separating membrane were consistent with inflammatory granulation tissue, similar to those of the outer membrane of CSDH.

Conclusion:

Exertional hypertension associated with the bench press may result in the rupture of fine arteries distributed over the AC wall. Under certain circumstances, the AC wall may transform into the outer membrane of CSDH.
Динамика биохимических показателей при моделировании неалкогольной жировой болезни печени различной степени тяжести
Authors: Т.В. Брус , А.Г. Васильев
Published: October 2024

Целью данного исследования было выявить специфические биохимические показатели для верификации степени тяжести неалкогольной жировой болезни печени. Материалы и методы. В эксперименте использовал два варианта модели неалкогольной жировой болезни печени: лёгкий – неалкогольный стеатоз, и тяжёлый вариант – неалкогольный стеатогепатит. Измеряли следующие биохимические показатели: активность ферментов аспартатаминотрансферазы (АСТ), аланинаминотрансферазы (АЛТ), щелочной фосфатазы (ЩФ), лактатдегидрогеназы (ЛДГ), концентрации глюкозы, общего билирубина (ОБил) и его прямой фракции (ПБ), общего белка (ОБ), концентрации гомоцистеина, триацилглицеридов (ТГ), общего холестерина (ОХ), супероксиддисмутазы (СОД), каталазы (Кат) и малонового диальдегида (МДА). Результаты. Степень тяжести развившихся стеатоза и стеатогепатита в экспериментальных группах была напрямую связана со способом моделирования неалкогольной жировой болезни печени. На модели стеатогепатита дисфункция печени была выражена в большей степени, чем в модели стеатоз; это различие проявлялось в более выраженном повышении АСТ, АЛТ, ЩФ, Обил, ОХ, МДА (p < 0,001) и снижении СОД, Кат (p < 0,05). Заключение. Исследование продемонстрировало целесообразность определения биохимических маркеров, в том числе уровней АЛТ, АСТ, ОБил, ТГ, МДА и СОД для оптимизации методологии лабораторной диагностики степени тяжести жировой дистрофии печени.

The aim of this study was to identify biochemical markers to determine the severity of non-alcoholic fatty liver disease. Materials and methods. In the experiment, we used two variants of the non-alcoholic fatty liver disease model: a mild one – non-alcoholic steatosis and a severe variant – non-alcoholic steatohepatitis. The following biochemical parameters were measured: enzyme activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), plasma glucose concentration, total protein (TP), total bilirubin (TBil) and its direct fraction (DF), plasma concentrations of homocysteine, total cholesterol (TC), triacylglycerides (TG), catalase (Cat), superoxide dismutase (SOD) and malondialdehyde (MDA). Results. The severity of developing steatosis and steatohepatitis in the experimental groups was directly related to the way nonalcoholic fatty liver disease was modeled. In the model of steatohepatitis, liver function was impaired to a much greater extent than with steatosis; this difference was manifested in a statistically significant increase in ALT, AST, ALP, TC, Obil, MDA (p<0.001) and a decrease in Cat, SOD (p<0.05). Conclusion. The study demonstrated the feasibility of determining biochemical markers, including the levels of ALT, AST, OBil, TG, MDA and SOD to optimize the methodology for laboratory diagnosis of the severity of fatty liver disease.
Физиологические механизмы и психологические факторы развития стресс-реакции у спортсменов высокой квалификации, занимающихся танцевальным спортом
Authors: И.Д. Коняев , Н.Н. Захарьева
Published: October 2024

Представлен обзор современной отечественной и зарубежной литературы, посвященной проблематике возникновения и проявления негативных стресс-реакций у спортсменов высокой квалификации, занимающихся танцевальным спортом. Продемонстрировано, что психологический стресс и психоэмоциональное напряжение у танцоров могут быть вызваны различными факторами, включая соревновательный стресс и организационный стресс, а также зависят от личных индивидуально-типологических качеств спортсмена. Развитию нервно-психического напряжения у спортсменов-танцоров может способствовать отсутствие финансовых средств и негативное воздействие «межличностных стрессоров». Исследования показывают, что танцоры-мужчины могут подвергаться насмешкам и оскорблениям из-за принадлежности к танцевальному спорту чаще, чем мужчины, занимающиеся другими видами спорта. Поскольку психоэмоциональное состояние одного партнера отражается на другом, то перспективным направлением является разработка копинг-стратегий и рекреационных программ для снижения высокого уровня тревожности и симптомов нервно-психического напряжения у спортсменов-танцоров.

This article presents an overview of modern domestic and foreign literature on the problems of the occurrence and manifestation of negative stress reactions of athletes-dancers. According to literary sources, it has been established that psychological stress and psycho-emotional tension in dancers can be caused by various factors, including competitive stress, organizational stress, and depend on the personal individual typological qualities of the athlete. The lack of financial resources and the negative impact of “interpersonal stressors” can contribute to the development of neuropsychic stress in athletes-dancers. Research shows that male dancers may be subjected to ridicule and insults because of their membership in dance sports more often than men involved in other sports. Since the psychoemotional state of one partner affects the other, a promising direction is the development of coping strategies and recreational programs to reduce anxiety and symptoms of neuropsychiatric stress in athletes-dancers.
Особенности ориентировочно-исследовательского поведения крыс при остеоартрите височно-нижнечелюстного сустава
Authors: А.В. Клименко , О.С. Романенко , Д.А. Черемисова , И.В. Алексеева , С.С. Перцов
Published: October 2024

Цель исследования: изучение ориентировочно-исследовательского поведения самок крыс в динамике наблюдений в тесте «открытое поле» на модели боли в челюстно-лицевой области. Материалы и методы: Исследование проведено на 18 самках крыс Wistar. Остеоартрит височно-нижнечелюстного сустава вызван внутрисуставным введением моноиодацетата натрия. Показатели поведения регистрировали в тесте «открытое поле» (ОП). Измерения проводили в исходном состоянии и через 14 дней после введения реагентов. Результаты. Показано, что самки крыс с болевым синдромом характеризуются снижением количества перемещений по периферическим секторам и увеличением времени груминга. К окончанию наблюдений латентный период первого движения в тесте «открытое поле» увеличивался у экспериментальных, но снижался у контрольных животных. В указанный период число пересеченных периферических секторов установки у крыс с индуцированным болевым синдромом было меньше контрольных значений. Через 2 недели после введения моноиодацетата натрия в височно-нижнечелюстной сустав число исследованных объектов в группе с остеоартритом было больше по сравнению с интактными особями. Заключение. Экспериментальный остеоартрит височно-нижнечелюстного сустава у самок крыс приводит к выраженному угнетению ориентировочно-исследовательского поведения при тестировании в открытом поле.

The aim: to investigate the orientation-research behaviour of female rats in the dynamics of observations in the “open field” test on the model of pain in the maxillofacial region. Material and methods. The study was conducted on 18 female Wistar rats. Osteoarthritis of the temporomandibular joint was induced by intra-articular injection of sodium monoiodoacetate. Behavioral performance was recorded in the open-field test. Measurements were taken at baseline and 14 days after reagent administration. Results. It was shown that female rats with pain syndrome were characterized by a decrease in the number of movements in peripheral sectors and an increase in grooming time. By the end of observations, the latent period of the first movement in the “open field” test increased in experimental animals, but decreased in control animals. During this period, the number of crossed peripheral sectors of the plant in rats with induced pain syndrome was lower than the control values. 2 weeks after the injection of sodium monoiodacetate into the temporomandibular joint, the number of examined objects in the group with osteoarthritis was greater compared to intact individuals. Conclusion. Experimental osteoarthritis of the temporomandibular joint in female rats leads to a pronounced inhibition of orienteering and exploratory behavior during open-field testing.
Значимость группы генов длинных некодирующих РНК в прогрессии рака яичников
Authors: С.С. Лукина , А.М. Бурдённый , И.В. Пронина , В.И. Логинов , Э.А. Брага
Published: October 2024

Рак яичников относится к наиболее агрессивным и неблагоприятным формам рака у женщин с быстрым прогрессированием и высоким метастатическим потенциалом. Ключевую роль в развитии этого заболевания может играть нарушение эпигенетической регуляции экспрессии длинных некодирующих РНК (днРНК) вследствие аберрантного метилирования их генов. Цель: изучить характер метилирования и экспрессии генов днРНК GAS5, HOTAIR и SNHG6 в опухолях больных раком яичников и оценить связь этих эпигенетических нарушений с прогрессией и метастазированием заболевания. Методы: Анализ уровней метилирования и экспрессии днРНК проводили методом ПЦР в реальном времени на выборке парных (опухоль/норма) образцов, полученных от пациенток с раком яичников. Статистический и корреляционный анализ выполняли в программной среде R. Результаты: Выявлено значимое повышение уровня метилирования генов GAS5, HOTAIR и SNHG6 в опухолевой ткани по сравнению с нормой. Тот же результат показан для генов GAS5 и SNHG6 при прогрессии опухоли, включая метастазирование. Уровень экспрессии при этом для HOTAIR и SNHG6 значимо снижался в опухоли. Выявлена отрицательная корреляция между уровнем метилированием гена SNHG6 и уровнем его экспрессии. Заключение: Полученные данные указывают на важную роль эпигенетической дерегуляции днРНК в патогенезе рака яичников и могут найти применение в прогнозировании и разработке персонализированных подходов к терапии.

Ovarian cancer is one of the most aggressive and unfavorable forms of cancer in women with rapid progression and high metastatic potential. A key role in the development of this disease may be played by a disruption in the epigenetic regulation of the expression of long non-coding RNAs (lncRNAs) due to aberrant methylation of their genes. Objective: To study the methylation and expression patterns of the lncRNA genes GAS5, HOTAIR, and SNHG6 in ovarian cancer tumors and evaluate the association of these epigenetic abnormalities with disease progression and metastasis. Methods: Analysis of lncRNA methylation and expression levels was performed by RT-PCR on paired (tumor/normal) samples obtained from ovarian cancer patients. Statistical and correlation analysis was performed in the R software environment. Results: A significant increase in the methylation level of the GAS5, HOTAIR, and SNHG6 genes was observed in tumor tissue compared to normal tissue. The same result was shown for the GAS5 and SNHG6 genes during tumor progression, including metastasis. The expression level for HOTAIR and SNHG6 was significantly decreased in the tumor. A negative correlation was found between the methylation level of the SNHG6 gene and its expression level. Conclusion: The obtained data indicate an important role of epigenetic deregulation of lncRNAs in the pathogenesis of ovarian cancer and may find application in predicting and developing personalized approaches to therapy.
Биоинформатический анализ генов и полиморфизмов, вовлеченных в старение и развитие заболеваний, ассоциированных с возрастом
Authors: А.А. Пахомов , Н.С. Карпова , О.П. Дмитренко
Published: October 2024

Целью работы было проведение биоинформатического анализа полиморфизмов генов, которые ассоциированы со старением и возраст-ассоциированными заболеваниями. Материалы и методы. Анализ генов проводился с использованием информации, полученной из базы данных полногеномных ассоциативных исследований GWAS Catalog. Для анализа белок-белковых взаимодействий (protein-protein interactions, PPI) использовалась база данных String-DB (версия 12.0). Результаты. Выявлено 7676 уникальных генов, полиморфизмы которых связаны с развитием возраст-ассоциированных заболеваний. Выявлена ассоциация молекулярных функций ряда генов (HLA-DQB1, HLA-DQA1, HLA-DRB1, FTO, APOE, APOC1 и MAPT) и их белковых продуктов со старением и возраст-ассоциированными заболеваниями.

The aim of the study was to perform a bioinformatic analysis of gene’s polymorphisms, associated with ageing and ageassociated diseases. Materials and methods. Analysis of genes was performed with the use of information, obtained from the database of genomewide association studies GWAS Catalog. String-DB database (v. 12.0) was used for analysis of protein-protein interactions (PPI). Results. 7676 unique genes have been identified, the polymorphisms of which are associated with the development of ageassociated diseases. The association of molecular functions of a number of genes (HLA-DQB1, HLA-DQA1, HLA-DRB1, FTO, APOE, APOC1 and MAPT) and their protein products with aging and age-associated diseases has been revealed.
Федеральный исследовательский центр оригинальных и перспективных биомедицинских и фармацевтических технологий
Authors: О.С. Романенко , Д.А. Черемисова , А.В. Клименко , А.Ю. Любимова , С.С. Перцов
Published: October 2024

Цель исследования: изучение изменений локомоторной активности, а также пищевого и питьевого поведения самок крыс на модели боли при остеоартрите височно-нижнечелюстного сустава. Материалы и методы. Исследования выполнены на 18 самках крыс Wistar. Животным вводили моноиодацетат натрия в височно-нижнечелюстной сустав. Для оценки суточной показателей двигательной активности крыс, объема потребляемой воды и пищи использовали автоматизированную установку Phenomaster (TSE Systems GmbH, Германия). Результаты. В динамике наблюдений установлено, что масса тела уменьшается у крыс с болевым синдромом, но увеличивается у контрольных животных. К окончанию опыта особи с индуцированной болью характеризовались снижением потребления корма и воды, а также уменьшением суточной двигательной активности. Заключение. Развитие болевого синдрома в челюстно-лицевой области приводит к подавлению локомоторной активности, угнетению пищевого и питьевого поведения.

The aim: study of changes in locomotor activity, as well as eating and drinking behavior of female rats on a model of pain in osteoarthritis of the temporomandibular joint. Material and methods. The studies were performed on 18 female Wistar rats. The animals were injected with sodium monoiodacetate in the temporomandibular joint. An automated Phenomaster unit (TSE Systems GmbH, Germany) was used to assess daily indices of the rats’ motor activity, water and food intake. Results. In the dynamics of observation it was found that body weight decreased in rats with pain syndrome, but increased in control animals. By the end of the experiment, individuals with induced pain were characterized by a decrease in feed and water consumption, as well as a decrease in daily motor activity. Conclusion. The development of pain syndrome in the maxillofacial region leads to suppression of locomotor activity, suppression of eating and drinking behavior.