bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacophore study, molecular docking and molecular dynamic simulation of virgin coconut oil derivatives as anti-inflammatory agent against COX-2
Authors: Jack Kho Swen , Asaruddin Mohd Razip Bin , Bhawani Showkat Ahmad
Published: October 2022

Background

Virgin coconut oil is mostly made up of saturated fatty acids in which approximately 72% are medium chain triglycerides. Medium chain triglycerides can be digested into medium chain fatty acids and medium chain monoglycerides which are bioactive components. Therefore, it is very important to study the in-silico ability of some Virgin coconut oil derivatives, namely, medium chain fatty acids and medium chain monoglycerides to inhibit Cyclooxygenase 2 (COX-2) protein for prevention of excessive inflammatory response.

Results

Pharmacophore study displayed monolaurin with two hydrogen bond donor, three hydrogen bond acceptor and five hydrophobic interactions, while lauric acid presented two hydrogen bond acceptor, five hydrophobic interactions and a negative ion interaction. Molecular docking underlined the ability of monolaurin in the inhibition of COX-2 protein which causes inflammatory action with a decent result of energy binding affinity of − 7.58 kcal/mol and 15 interactions out of which 3 are strong hydrogen bond with TYR385 (3.00 Å), PHE529 (2.77 Å), and GLY533 (3.10 Å) residues of the protein. Monolaurin was employed as hydrogen bond acceptor to the side of residue TYR385 of COX-2 protein with an occupancy of 67.03% and was observed to be long-living during the entire 1000 frames of the molecular dynamic simulation. The analysis of RMSD score of the Monolaurin–COX-2 complex backbone was calculated to be low (1.137$$\pm$$±0.153 Å) and was in a stable range of 0.480 to 1.520 Å. Redocking of this complex still maintained a strong hydrogen bond (2.87 Å) with the main residue TYR385. AMDET results where promising for medium chain fatty acids and medium chain monoglycerides with good physicochemical drug scores.

Conclusions

This can be concluded from the results obtained that the monolaurin has strong interactions with COX-2 protein to disrupt its function due to significant hydrogen bonds and hydrophobic interactions with amino acid residues present in the target protein’s active site. These results displayed a very significant anti-inflammatory potential of monolaurin and a new promising drug candidates as anti-inflammatory agent.

Graphical Abstract
An analysis of cultural dissemination and national image construction in Chinese influencer Li Ziqi’s vlogs and its impact on international viewer perceptions on YouTube
Authors: Whyke Thomas William , Chen Zhen Troy , Lopez-Mugica Joaquin
Published: October 2022

International social exchanges have always been important to China’s cultural soft power and image construction overseas. This study focuses on an internationally renowned mega influencer Li Ziqi and her vlogs on YouTube. These orchestrated vlogs tell stories of rural Chinese life and construct a desirable traditional Chinese rural culture for netizens at home and abroad. Informed by framing and cultivation theory, this study examines how user-generated content on national images can affect social media users’ perceptions of reality. Content analysis is used to analyze the visual portrayals of Chinese rural culture, including its customs and values, aesthetics, and cultural and scenic places in Li’s vlogs. Discourse analysis is further used to examine user comments and demonstrate her vlog content’s impact on user perceptions of Chinese rural culture. This study sheds light on how a complex and hybrid national image with ‘Chineseness,’ and a personal image with self-Orientalized and performed ‘soft but independent’ Chinese rural female image, is constructed by a social media influencer Li Ziqi with affective associations. At a conceptual and practical level, the findings of this study contribute to the ongoing scholarly discussions on how China engages with the globalized world through cultural diplomacy from the bottom-up, while existing research primarily takes a top-down approach.
Massive duodenal ulcer bleeding due to the ruptured hepatic artery pseudoaneurysm after living donor liver transplantation
Authors: Kadohisa Masashi , Inomata Yukihiro , Sakisaka Masataka , Sugawara Yasuhiko , Hibi Taizo
Published: October 2022

Background

The rupture of a hepatic artery pseudoaneurysm (HAP) is a rare but lethal complication after living donor liver transplantation (LDLT) and often manifests as acute gastrointestinal bleeding.

Case presentation

This report describes three patients who experienced HAP after LDLT. These patients initially presented with active bleeding of a duodenal ulcer (DU) in the duodenal bulb, followed by diagnosis of the ruptured HAP by angiography. None of the patients had evidence of an active intra-abdominal infection or bile leakage preceding the rupture of HAP. All patients were initially treated by transcatheter arterial coil embolization (TAE). In all cases, TAE was successful for hemostasis but resulted in complete obstruction of the arterial inflow to the graft. Arterial revascularization by surgical reconstruction using the autologous arterial graft in one case and re-LDLT in another one was successfully performed. The other one succumbed to sepsis caused by later liver abscesses.

Conclusion

This is the first detailed case series of massive DU bleeding as a warning signal of ruptured HAP after LDLT. HAP should be included in the differential diagnosis when an LDLT recipient presents with gastrointestinal bleeding.
Implantable micro-scale LED device guided photodynamic therapy to potentiate antitumor immunity with mild visible light
Authors: Choi Jiwoong , Lee Il Seong , Lee Ju Seung , Jeon Sangmin , Yun Wan Su , Yang Suah , Moon Yujeong , Kim Jinseong , Kim Jeongrae , Choy Seunghwan , Jeong Chanho , Shim Man Kyu , Kim Tae-il , Kim Kwangmeyung
Published: October 2022

Background

Photodynamic therapy (PDT) is a promising strategy to promote antitumor immunity by inducing immunogenic cell death (ICD) in tumor cells. However, practical PDT uses an intense visible light owing to the shallow penetration depth of the light, resulting in immunosuppression at the tumor tissues.

Methods

Herein, we propose an implantable micro-scale light-emitting diode device (micro-LED) guided PDT that enables the on-demand light activation of photosensitizers deep in the body to potentiate antitumor immunity with mild visible light.

Results

The micro-LED is prepared by stacking one to four micro-scale LEDs (100 μm) on a needle-shape photonic device, which can be directly implanted into the core part of the tumor tissue. The photonic device with four LEDs efficiently elicits sufficient light output powers without thermal degradation and promotes reactive oxygen species (ROS) from a photosensitizer (verteporfin; VPF). After the intravenous injection of VPF in colon tumor-bearing mice, the tumor tissues are irradiated with optimal light intensity using an implanted micro-LED. While tumor tissues under intense visible light causes immunosuppression by severe inflammatory responses and regulatory T cell activation, mild visible light elicits potent ICD in tumor cells, which promotes dendritic cell (DC) maturation and T cell activation. The enhanced therapeutic efficacy and antitumor immunity by micro-LED guided PDT with mild visible light are assessed in colon tumor models. Finally, micro-LED guided PDT in combination with immune checkpoint blockade leads to 100% complete tumor regression and also establishes systemic immunological memory to prevent the recurrence of tumors.

Conclusion

Collectively, this study demonstrates that micro-LED guided PDT with mild visible light is a promising strategy for cancer immunotherapy.
Demographics Matter: Non-white and White Life Science Graduate Students Perceive and Use Resources Differently
Authors: Weatherton Maryrose , Schussler Elisabeth E.
Published: October 2022

We employed a national survey of life science graduate students ( N = 534) to describe student resource use outcomes and how these outcomes may be related to student demographic characteristics. ANOVA modeling indicated that student characteristics impacted resource use outcomes, with the greatest differentials between white and nonwhite students.
Defining the Current Landscape, Attitudes, and Perceived Barriers of Virtual Medicine in Underserved Populations
Authors: Hundal Jasmin , Bade Katarina , Hsu Emily , Chhabra Jyoti , Menendez Alvaro
Published: October 2022

PURPOSE:

Virtual medicine (VM) use increased during the COVID-19 pandemic as it represented a safe alternative to traditional face-to-face health care delivery. This prospective cross-sectional study aimed to characterize preferences and perceived barriers to VM on the basis of language and specific sociodemographic variables while also identifying particular subpopulations at risk of dissatisfaction regarding VM.

METHODS:

An institutional review board–approved, 23-item questionnaire was offered in English and Spanish. Examined variables included demographic information, preferences, and perceived barriers regarding VM. Multivariable analysis was performed to determine the association between demographic variables and participants' preferences and perceived barriers.

RESULTS:

Fewer Hispanic and underserved patients (N = 241) had received oncological care through VM (28.9% v 30.8%) despite comparable preferences and levels of satisfaction regarding the incorporation of VM in health care delivery (21.6% v 25.4%; 68.7% v 82.1%), respectively, with no significant difference by age, level of education, marital status, or Hispanic ethnicity, although Spanish as primary language was statistically significant ( P = .001). Although Hispanic and underserved rely more on social media to receive health information (26.5% v 24.7%), they have more technical barriers. They were up to 2.9 times more likely not to have a phone/iPad/similar or access broadband connectivity.

CONCLUSION:

Given the shift toward outpatient and home-based care, an aging population, and cultural appropriations, VM excitedly allows the reincorporation of family/caregiver in medical engagement. Hispanic patients are equally interested and satisfied in receiving oncological care through VM, but fewer are currently using it. Barriers are predominantly technical and targetable with appropriate policies to help overcome technological barriers on the basis of language, ethnic, locoregional, and sociodemographic variables.
New Growth
Authors: Cobb Jasmine Nichole
Published: October 2022

From Frederick Douglass to Angela Davis, “natural hair” has been associated with the Black freedom struggle. In New Growth Jasmine Nichole Cobb traces the history of Afro-textured coiffure, exploring it as a visual material through which to reimagine the sensual experience of Blackness. Through close readings of slave narratives, scrapbooks, travel illustrations, documentary films, and photography as well as collage, craft, and sculpture, from the nineteenth century to the present, Cobb shows how the racial distinctions ascribed to people of African descent become simultaneously visible and tactile. Whether examining Soul Train’s and Ebony’s promotion of the Afro hairstyle alongside styling products or how artists such as Alison Saar and Lorna Simpson underscore the construction of Blackness through the representation of hair, Cobb foregrounds the inseparability of Black hair’s look and feel. Demonstrating that Blackness is palpable through appearance and feeling, Cobb reveals the various ways that people of African descent forge new relationships to the body, public space, and visual culture through the embrace of Black hair.
Concurrent Administration of Immune Checkpoint Inhibitors and Stereotactic Radiosurgery Is Well-Tolerated in Patients With Melanoma Brain Metastases: An International Multicenter Study of 203 Patients
Authors: Lehrer Eric J. , Gurewitz Jason , Bernstein Kenneth , Kondziolka Douglas , Fakhoury Kareem R. , Rusthoven Chad G. , Niranjan Ajay , Wei Zhishuo , Lunsford L. Dade , Malouff Timothy D. , Ruiz-Garcia Henry , Peterson Jennifer L. , Bonney Phillip , Hwang Lindsay , Yu Cheng , Zada Gabriel , Deibert Christopher P. , Prasad Rahul N. , Raval Raju R. , Palmer Joshua D. , Patel Samir , Picozzi Piero , Franzini Andrea , Attuati Luca , Mathieu David , Trudel Claire , Lee Cheng-chia , Yang Huai-che , Jones Brianna M. , Green Sheryl , Ahluwalia Manmeet S. , Sheehan Jason P. , Trifiletti Daniel M.
Published: October 2022

BACKGROUND:

Melanoma brain metastases are commonly treated with stereotactic radiosurgery (SRS) and immune checkpoint inhibitors (ICIs). However, the toxicity of these 2 treatments is largely unknown when administered concurrently.

OBJECTIVE:

To evaluate the risk of radiation necrosis (RN) with concurrent and nonconcurrent SRS and ICIs.

METHODS:

The guidelines from the Strengthening the Reporting of Observational Studies in Epidemiology checklist were used. Inverse probability of treatment weighting, univariable and multivariable logistic regression, and the Kaplan-Meier method was utilized.

RESULTS:

There were 203 patients with 1388 brain metastases across 11 international institutions in 4 countries with a median follow-up of 15.6 months. The rates of symptomatic RN were 9.4% and 8.2% in the concurrent and nonconcurrent groups, respectively (P =.766). On multivariable logistic regression, V12 ≥ 10 cm3 (odds ratio [OR]: 2.76; P =.006) and presence of BRAF mutation (OR: 2.20; P =.040) were associated with an increased risk of developing symptomatic RN; the use of concurrent over nonconcurrent therapy was not associated with an increased risk (OR: 1.06; P =.877). There were 20 grade 3 toxic events reported, and no grade 4 events reported. One patient experienced a grade 5 intracranial hemorrhage. The median overall survival was 36.1 and 19.8 months for the concurrent and nonconcurrent groups (log-rank P =.051), respectively.

CONCLUSION:

Concurrent administration of ICIs and SRS are not associated with an increased risk of RN. Tumors harboring BRAF mutation, or perhaps prior exposure to targeted agents, may increase this risk. Radiosurgical optimization to maintain V12 < 10 cm3 is a potential strategy to reduce the risk of RN.
Prognosis of Rotational Angiography-Based Stereotactic Radiosurgery for Dural Arteriovenous Fistulas: A Retrospective Analysis
Authors: Shinya Yuki , Hasegawa Hirotaka , Kawashima Mariko , Koizumi Satoshi , Katano Atsuto , Umekawa Motoyuki , Saito Nobuhito
Published: October 2022

BACKGROUND:

Cerebral dural arteriovenous fistulas (DAVFs) are intracranial vascular malformations with fine, abnormal vascular architecture. High-resolution vascular imaging is vital for their visualization. Currently, rotational angiography (RA) provides the finest 3-dimensional visualization of the arteriovenous shunt with high spatial resolution; however, the efficacies of the integration of RA have never been studied in stereotactic radiosurgery (SRS) for DAVFs until now. Since 2015, our institution has integrated RA into SRS (RA-SRS) to provide more conformal planning, thereby decreasing overtreatment and undertreatment.

OBJECTIVE:

To analyze the outcomes of RA-SRS for DAVFs.

METHODS:

We retrospectively analyzed the outcomes of 51 patients with DAVFs and compared those of 20 DAVFs treated with RA-SRS with those of 31 DAVFs treated with conventional SRS (c-SRS).

RESULTS:

The time to obliteration was shorter in the RA-SRS group (median, 15 months vs 26 months [cumulative rate, 77% vs 33% at 2 years, 77% vs 64% at 4 years]; P = .015). Multivariate Cox proportional hazards analysis demonstrated that RA-SRS (hazard ratio 2.39, 95% CI 1.13-5.05; P = .022) and the absence of cortical venous reflux (hazard ratio 2.12, 95% CI 1.06-4.25; P = .034) were significantly associated with obliteration. The cumulative 5-year post-SRS stroke-free survival rates were 95% and 97% in the RA-SRS and c-SRS groups, respectively (P = .615). Neurological improvement tended to occur earlier in the RA-SRS group than in the c-SRS group (median time to improvement, 5 months vs 20 months, log-rank test; P = .077).

CONCLUSION:

RA-based SRS may facilitate earlier fistula obliteration and may contribute to early neurological improvement.
Once upon a dish: the next frontier in engineering multicellular systems
Authors: Huch Meritxell , Gouti Mina
Published: October 2022

In June 2022, the second meeting on ‘Engineering Multicellular Systems’, organized by the European Molecular Biology Laboratory and the Institute of Bioengineering of Catalonia, took place in Barcelona. Stem cell and systems biologists, physicists and engineers from all over the world gathered to discuss how recent breakthroughs in organoid technologies, engineering and mechanobiology are boosting our understanding of early morphogenesis, organogenesis and organ function with applications in tissue engineering, disease modeling and drug screening. The meeting was organized with sustainability in mind, and included an ethics session and an outreach public activity.
Progression of the pluripotent epiblast depends upon the NMD factor UPF2
Authors: Chousal Jennifer N. , Sohni Abhishek , Vitting-Seerup Kristoffer , Cho Kyucheol , Kim Matthew , Tan Kun , Porse Bo , Wilkinson Miles F. , Cook-Andersen Heidi
Published: October 2022

Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathway that degrades RNAs harboring in-frame stop codons in specific contexts. Loss of NMD factors leads to embryonic lethality in organisms spanning the phylogenetic scale, but the mechanism remains unknown. Here, we report that the core NMD factor, UPF2, is required for expansion of epiblast cells within the inner cell mass of mice in vivo. We identify NMD target mRNAs in mouse blastocysts – both canonical and alternatively processed mRNAs – including those encoding cell cycle arrest and apoptosis factors, raising the possibility that NMD is essential for embryonic cell proliferation and survival. In support, the inner cell mass of Upf2-null blastocysts rapidly regresses with outgrowth and is incompetent for embryonic stem cell derivation in vitro. In addition, we uncovered concordant temporal- and lineage-specific regulation of NMD factors and mRNA targets, indicative of a shift in NMD magnitude during peri-implantation development. Together, our results reveal developmental and molecular functions of the NMD pathway in the early embryo.
The Cancer Hub Approach for Upper Gastrointestinal Surgery During COVID-19 Pandemic: Outcomes from a UK Cancer Centre
Authors: Doyle Joseph P. , Patel Pranav H. , Doran Sophie L. F. , Jiao Long R. , Cunningham David , Nicol David , Mavroeidis Vasileios K. , Allum William H. , Chaudry Asif M. , Bhogal Ricky H. , Kumar Sacheen
Published: October 2022

Background

The coronavirus disease 2019 (COVID-19) pandemic caused unprecedented disruption to global healthcare delivery. In England, the majority of elective surgery was postponed or cancelled to increase intensive care capacity. Our unit instituted the ‘RM Partners Cancer Hub’ at the Royal Marsden Hospital in London, to deliver ongoing cancer surgery in a ‘COVID-lite’ setting. This article describes the operational set-up and outcomes for upper gastrointestinal (UGI) cancer resections performed during this period.

Methods

From April 2020 to April 2021, the Royal Marsden Hospital formed the RM Partners Cancer Hub. This approach was designed to coordinate resources and provide as much oncological treatment as feasible for patients across the RM Partners West London Cancer Alliance. A UGI surgical case prioritisation strategy, along with strict infection control pathways and pre-operative screening protocols, was adopted.

Results

A total of 231 patients underwent surgery for confirmed or suspected UGI cancer during the RM Partners Cancer Hub, with 213 completed resections and combined 90-day mortality rate of 3.5%. Good short-term survival outcomes were demonstrated with 2-year disease free survival (DFS) and overall survival (OS) for oesophageal (70.8% and 72.9%), gastric (66.7% and 83.3%) and pancreatic cancer resections (68.0% and 88.0%). One patient who developed perioperative COVID-19 during the RM Partners Cancer Hub operation made a full recovery with no lasting clinical sequelae.

Conclusion

Our experience demonstrates that the RM Partners Cancer Hub approach is a safe strategy for continuing upper gastrointestinal (GI) resectional surgery during future periods of healthcare service disruption
Measurements of projectile fragments from 70 Zn (15 MeV/nucleon) + 64 Ni collisions with the MAGNEX spectrometer at INFN-LNS
Authors: Koulouris Stergios , Souliotis Georgios , Cappuzzello Francesco , Carbone Diana , Pakou Athena , Agodi Clementina , Brischetto Giuseppe , Calabrese Salvatore , Cavallaro Manuela , Ciraldo Irene , Fasoula Olga , Klimo Jozef , Palli Konstantina , Sgouros Onoufrios , Soukeras Vasileios , Spatafora Alessandro , Torresi Domenico , Veselsky Martin
Published: October 2022

The present work is focused on our efforts to produce and identify neutron-richrare isotopes from peripheral reactions below the Fermi energy. High-quality experimental data were obtained from a recent experiment with the MAGNEX spectrometer at INFN-LNS in Catania, Italy. The main goal of this effort is to describe the adopted identification techniques used to analyze the data from the reaction 70 Zn (15 MeV/nucleon) + 64 Ni. The particle identification procedure is based on a novel approach that involves the reconstruction of both the atomic number Z and the ionic charge q of the ions, followed by the identification of themass. Our method was successfully applied to identify neutron-rich ejectiles from multinucleon transfer in the above reaction 70 Zn + 64 Ni at 15 MeV/nucleon. The analysis of the data is ongoing. We expect to obtain the angular and momentum distributions of the fragments, along with their production cross sections. These data, along with comparisons with theoretical models are expected to contribute to a better understanding of the complex reaction mechanisms of multinucleon transfer that dominate this energy regime.
Study of Multinucleon Transfer Mechanisms in 86Kr-Induced Peripheral Reactions at 15 and 25 MeV/nucleon
Authors: Fasoula Olga , Souliotis George , Koulouris Stergios , Palli Konstantina , Veselsky Martin , Yenello Sherry , Bonasera Aldo
Published: October 2022

This paper presents our recent studies of the multinucleon transfer in peripheral collisions in reactions near the Fermi regime. Specifically, the reactions of a 86Kr beam at 15 MeV/nucleon with targets of 124Sn ,112Sn, 64Ni and 58Ni and reactions of a 86Kr beam at 25 MeV/nucleon with targets of 124Sn and 112Sn. The experimental data were obtained from the previous work of our group with the MARS spectrometer at the Cyclotron Institute of Texas A&M University. Our current focus is the thorough study of the experimental mass and momentum distributions of the projectile-like fragments. The momentum distributions are characterised by a narrow quasi-elastic peak and a broader deep-inelastic peak. We employed two-body kinematics to characterize the excitation energies of these reactions. We also compared the data with model calculations. The dynamical stage is described with either the Deep-Inelastic Transfer Model (DIT), or with the microscopic Constrained Molecular Dynamics model (CoMD). The de-excitation of the hot projectile-like fragments is performed with the Gemini model. Studying these reactions will provide us with a better understanding as to how the energy of the beam and the different targets affect the mechanism of the multinucleon transfer reactions. With the recent work, our continued efforts in the study of peripheral reactions in the Fermi energy regime delineate new opportunities to elucidate the reaction mechanism(s) of rare isotope production and may effectively contribute to the study of unexplored regions of the nuclear chart toward the r-process and the neutron drip line.
The Non-Linear Derivative (NLD) model for the in-medium hyperons & antihyperons dynamics
Authors: Chorozidou Arsenia , Gaitanos Theodoros
Published: October 2022

The in-medium properties of hyperons and antihyperons are studied with the Non-Linear Derivative (NLD) model and focus is made on the momentum dependence of strangeness optical potentials[1]. The NLD model is based on the Relativistic Mean Field (RMF) approximation to Relativistic Hadrodynamics (RHD) approach of nuclear systems, but it incorporates an explicit momentum dependence of mean-fields. The extension of the NLD model to the baryon and antibaryon octet is based on SU(6) and G-parity arguments. It is demonstrated that with a proper choice of momentum cut-offs, the Λ and Σ optical potentials are consistent with recent studies of the chiral effective field theory and Ξ optical potentials are consistent with Lattice-QCD calculations, over a wide momentum region. We also present NLD predictions for the in-medium momentum dependence of antiΛ, antiΣ and antiΞ hyperons. This work is important for future experimental studies, like CBM, PANDA at FAIR and is relevant to nuclear astrophysics as well.
Impact of nuclear mass measurements in the vicinity of 132Sn on the r-process nucleosynthesis
Authors: NIKAS STYLIANOS , Kankainen Anu , Beliuskina Olga , Nesterenko Dmitrii
Published: October 2022

Nuclear masses are a key aspect in the modelling of nuclear reaction rates for the r-process nucleosynthesis. High precision mass measurements drastically reduce the associated uncertainties in the modelling of r-process nucleosynthesis. We investigate the impact of nuclear mass uncertainties on neutron-capture rates calculations using a Hauser – Feshbach statistical code in the vicinity of 132Sn. Finally, we study the impact of the propagated neutron-capture reaction rates uncertainties on the r-process nucleosynthesis. We find that mass measurements with uncertainties higher than 20 keV affect the calculation of reaction rates. We also note that modelling of reaction rates can differ for more than a factor of two even for experimentally known nuclear masses.
Experimental Study of the Nuclear Structure of 180Hf: Preliminary results
Authors: Vasileiou Polytimos , Mertzimekis Theo J. , Chalil Achment , Zyriliou Aikaterini , Pelonis Stefanos , Lagaki Varvara , Siltzovalis Georgios , Efstathiou Margarita , Koseoglu Pavlos , Bonatsos Dennis , Martinou Andriana , Minkov Nikolay , Marginean Nicolae , Mihai Constantin , Florea Nicoleta , Ujeniuc Sorin , Tuturica Andrei , Costache Cristian , Mihai Radu , Stan Lucian , Filipescu Dan , Toma Sebastian , Gheorghe Ioana , Dinescu Irina , Ionescu Alina , Stoica Liviu , Calinescu Stefana , Oprea Andreea , Stoica Alexandru , Sotty Christophe , Clisu Cristina , Nita Cristina , Neascu Catalin
Published: October 2022

This work features preliminary results from a recent experimental campaign at IFIN-HH, Romania, aimed at measuring lifetimes of excited states in the neutron-rich 180Hf, by means of the RDDS technique. The 181Ta(11B,12C)180Hf proton pick-up reaction was used to populate excited states in the 180Hf nucleus. The ROSPHERE array loaded with 25 HPGe detectors was employed for the detection of the γ transitions depopulating the levels of interest. The array was coupled to the SORCERER particle detector and a plunger device enabling the study of p-γ and p-γ-γ coinciding events. Six different plunger foil distances were chosen, allowing for the construction of the decay curves of the observed γ transitions of interest, from which the corresponding level lifetimes can subsequently be deduced.
R-matrix Calculations for Proton Elastic Scattering on natMg in the Energy Range E = 2.45 - 4.25 MeV, Suitable for EBS
Authors: Maragkos Fotis , Alvanou Eleni , Axiotis Michail , Bligoura Natalia , Harissopulos Sotirios , Kokkoris Michail , Lagoyannis Anastasios , Ntemou Eleni , Preketes - Sigalas Konstantinos
Published: October 2022

In the present work R-Matrix calculations regarding the differential cross sections of the natMg(p,p0)natMg elastic scattering for Ep,lab = 0.70 – 4.25 MeV were implemented using the Azure2 code [1]. A coherent set of differential cross sections, the first to cover the Ep,lab = 2.45 – 4.25 MeV energy range [2], measured at the Tandem Accelerator laboratory of NCSR “Demokritos” was used as a basis for the calculations. These results were able to accurately reproduce both the experimental dataset as well as the current evaluation [3] which covers the Ep,lab = 0.7 to 2.7 MeV energy range.
Measurement of the 230Th(n,f) cross-section at the CERN n_TOF facility
Authors: Michalopoulou Veatriki , Diakaki Maria , Eleme Zinovia , Kokkoris Michael , Patronis Nikolaos , Stamatopoulos Athanasios , Tsinganis Andrea , Vlastou Roza , Collaboration N_TOF
Published: October 2022

The study of neutron induced reactions on actinides is of great importance both for the design of advanced nuclear systems and for fundamental research. The design of Generation IV reactors, Accelerator Driven Systems (ADS), as well as the study of alternative fuel cycles, such as the thorium fuel cycle, highlight the need for accurate cross-section data. In addition, fission cross-section data can assist in the study of the fission process and the fission barrier.Specifically, 230Th is produced from the alpha decay of 234U in the thorium fuel cycle, thus its fission cross-section is required with high accuracy. In addition, in the fission cross-section of thorium isotopes narrow resonances and fine structures are present, which cannot be explained efficiently by the double-humped fission barrier. For 230Th, previous measurements have shown a resonance at ~720 keV with additional fine structures. However, few discrepant experimental data exist in literature covering the energy region from the fission threshold up to 25 MeV.For these reasons, the fission cross-section of 230Th was measured at the CERN n_TOF facility, with the time-of-flight technique in order to cover the energy range of the previous measurements and extend the measurements to higher energies. The measurements were performed with Micromegas detectors, while the high purity 230Th were produced at JRC-Geel in Belgium. The analysis procedure for the cross-section results are on the final stages. In this work, a study on the angular distributions of 230Th, performed for the first time with this kind of Micromegas detectors is presented.
Temperature-dependent relative self-absorption measurements in 27Al
Authors: Koseoglou Pavlos , Cortés M. L. , Isaak J. , Werner V. , Papst O. , Kleemann J. , Beuschlein M. , Pietralla N. , Ahmed U. , Ide K. E. , Jurosevic I. , Nickel C. , Spall M. , Stetz T. , Zidarova R.
Published: October 2022

Nuclear resonance fluorescence measurements provide direct sensitivity to ground-state transition widths by probing the photoexcitation process of nuclear resonances. A technique in Relative Self-Absorption (RSA) measurements, in which measurements are done at multiple absorber temperatures, was developed and tested with 27Al at the Darmstadt High Intensity Photon Setup of the Superconducting Darmstadt Linear Accelerator. The advantage of this technique, over the regular RSA, is the possibility to overcome the need for theory input on the effective temperatures and the uncertainties that they introduce in the measured level widths. The technique and the preliminary results of the first test-measurements are presented in this proceedings.
Variation in the stable isotope trophic position of the bluefish Pomatomus saltatrix (Linnaeus, 1766) from two Mediterranean sites: insights from a global meta-analysis
Authors: MANCINI FRANCESCO , LILLO ANTONIO OSCAR , BARDELLI ROBERTA , VIZZINI SALVATRICE , MANCINELLI GIORGIO
Published: October 2022

A direct consequence of sea warming is the shift in the distribution range of thermo-tolerant species that have the potential to determine novel inter-specific interactions, ultimately altering food web structures and ecosystem processes. In this study, we investigated the trophic position of the bluefish Pomatomus saltatrix (Linnaeus, 1766), a pelagic predator that has recently expanded its distribution in the Mediterranean basin and for which scant information is available on its functional role in recently-colonised areas. Nitrogen and carbon stable isotopes were determined in muscle tissues of bluefish specimens collected in south-east Italy in the Gulf of Taranto (NW Ionian Sea) and in the Strait of Otranto (SW Adriatic Sea) at two coastal sites showing contrasting oceanographic conditions. The bluefish trophic position (TP) was estimated using locally abundant forage fish species as isotopic baselines. The results indicated for bluefish from the Strait of Otranto a TP value of 5.1, significantly higher than that determined in the Gulf of Taranto (4.2), and exceeding stomach content-based estimations reported by the online database FishBase and by literature sources. A synthesis of 30 publications reporting isotopic data for the bluefish and its potential prey at a global scale indicated that the species’ trophic position varied considerably between 2.7 and 5.2. The observed variability depended on locationand on the baseline species used in the estimations. Yet, a significant difference in trophic position was observed for bluefish from transitional and inshore environments as compared with offshore areas, mirroring the results obtained from the Gulf of Taranto and the Strait of Otranto. The findings of the study highlight the high trophic plasticity characterizing the bluefish in recently colonized areas, suggesting that it may play a key role in facilitating the expansion of its distribution range. However, additional investigations are essential to provide an advanced resolution of the bluefish functional role in Mediterranean coastal food webs.
Identificazione e analisi dei contenuti nautici nel Periplo dello Ps.Scilace.
Authors: Mauro Chiara Maria
Published: October 2022

Il Periplo dello Ps.Scilace è un testo controverso. Negli anni ’70 Aurelio Peretti lo definì come “il primo portolano del Mediterraneo”, facendo leva su una sua presunta finalità pratica. Successivi studi hanno, però, smentito questa ipotesi, sottolineando piuttosto tutti quegli elementi che rendono il testo inaffidabile nel corso di una traversata marittima. Questo contributo riprende l’ipotesi espressa dal Peretti, ma non col fine di propugnare l’uso pratico del Periplo; si propone, invece, di identificare e analizzare i contenuti probabilmente mutuati da fonti nautiche di epoca precedente al fine di avanzare ipotesi sulla natura della tradizione documentale anteriore.
Sobre el nombre del río Tiberis (Tíber) .
Authors: García Domingo Enrique
Published: October 2022

El artículo pretende dar respuesta a las siguientes preguntas: a) ¿El nombre del río Tiberis es latino o tiene origen etrusco? ¿Cómo lo llamaron los etruscos? Para averiguarlo, nos serviremos de los praen. lat. Tiberius, etr. Θihvaries, Θefarie, Θefri. b) ¿Dónde, cuándo y por qué recurrieron los griegos a Θύβρις, variante de Τίβερις, para denominar al río de Roma? c) ¿Es etrusco Thybris, el nombre del río Tiberis en la Eneida, y cuál es la etimología de este último, según Virgilio?
Bidones de plomo y la necesidad de agua potable en las minas romanas.
Authors: García Romero José
Published: October 2022

Estudio de dos bidones de plomo mineros para agua potable, con epígrafe de una societas familiar inédita, depositado en el Museo PRASA de Torrecampo (Córdoba, España), fechables a inicios del Imperio.
PROCESOS DE PATRIMONIALIZACIÓN, TURISMO DE BASE LOCAL Y SOSTENIBILIDAD. EL CASO DE EL CASTILLO (RÍO SAN JUAN, NICARAGUA).
Authors: Díaz Aguilar Antonio Luis
Published: October 2022

En las últimas décadas hemos asistido a cambios importantes en los procesos de patrimonialización y en la evolución del propio concepto de patrimonio. A los procesos de activación patrimonial, antes circunscritos a la labor de técnicos y académicos, se han incorporado nuevos agentes, desde grupos empresariales hasta colectivos integrantes de movimientos sociales. En las Ciencias Sociales es cada vez más compartida la concepción del patrimonio como construcción social y como proceso, observándose asimismo una convergencia de las dimensiones cultural y natural en su conceptualización, incorporándose en los últimos años la noción de sostenibilidad. En este artículo proponemos el uso del concepto de resiliencia socioecológica para analizar en qué medida los procesos de patrimonialización generan, mantienen o merman la sostenibilidad de un socioecosistema. Como ejemplo de su operativización presentamos el caso de El Castillo, una localidad del sur de Nicaragua, cuyo proceso puede ser definido como positivo, ya que la patrimonialización llevada a cabo y el desarrollo de un turismo de base local basado en los elementos patrimonializados han contribuido al reforzamiento de los factores que componen la resiliencia social y en buena medida ecológica de este socioecosistema, contribuyendo con ello a su sostenibilidad socioecológica.
Beating the Algorithm: Consumer Manipulation, Personalized Pricing, and Big Data Management
Authors: Li Xi , Li Krista J.
Published: October 2022

Problem definition: Firms heavily invest in big data technologies to collect consumer data and infer consumer preferences for price discrimination. However, consumers can use technological devices to manipulate their data and fool firms to obtain better deals. We examine how a firm invests in collecting consumer data and makes pricing decisions and whether it should disclose its scope of data collection to consumers who can manipulate their data. Methodology/results: We develop a game-theoretic model to consider a market in which a firm caters to consumers with heterogeneous preferences for a product. The firm collects consumer data to identify their types and issue an individualized price, whereas consumers can incur a cost to manipulate data and mimic the other type. We find that when the firm does not disclose its scope of data collection to consumers, it collects more consumer data. When the firm discloses its scope of data collection, it reduces data collection even when collecting more data is costless. The optimal scope of data collection increases when it is more costly for consumers to manipulate data but decreases when consumer demand becomes more heterogeneous. Moreover, a lower cost for consumers to manipulate data can be detrimental to both the firm and consumers. Lastly, disclosure of data collection scope increases firm profit, consumer surplus, and social welfare. Managerial implications: Our findings suggest that a firm should adjust its scope of data collection and prices based on whether the firm discloses the data collection scope, consumers’ manipulation cost, and demand heterogeneity. Public policies should require firms to disclose their data collection scope to increase consumer surplus and social welfare. Even without such a mandatory disclosure policy, firms should voluntarily disclose their data collection scope to increase profit. Moreover, public educational programs that train consumers to manipulate their data or raise their awareness of manipulation tools can ultimately hurt consumers and firms.

Funding: X. Li acknowledges financial support from the Hong Kong Research Grants Council [Grant 21500920]. K. J. Li acknowledges financial support from the Weimer Faculty Fellowship.

Supplemental Material: The Online Appendix is available at https://doi.org/10.1287/msom.2022.1153 .
A Dasatinib-Induced Chylothorax Persisting After the Discontinuation of Dasatinib
Authors: Bradt Nicolas , Olbrechts Frederic , Alexander Patrick , Salembier Alexander
Published: October 2022

Dasatanib is a second-generation tyrosine kinase inhibitor with activity on the BCR-ABL fusion gene. it is used in the treatment of BCR-ABL positive chronic myeloid leukaemia and has the known side effect of pleural effusion. This usually involves exudate with the presence of lymphocytes. A more common side effect is the development of chylothorax. We describe a case of a 67-years-old man with chronic myeloid leukaemia, for which treatment with dasatinib, with the presence of a right-sided chylothorax. The man presented at an outpatient consultation due to complaints for exertional dyspnoea. Radiographic imaging showed the presence of right-sided pleural effusion. Several punctures were performed with an evacuation of 4,900 mL bloody chylous fluid in total. Each puncture revealed an increased concentration of triglycerides on the fluid, hence confirming a recurring chylothorax. A pleurodesis was performed as a final therapy. Bosutinib was substituted for dasatinib eight months prior to initial admission, making this the first reported persisting dasatinib-induced chylothorax after discontinuation.
An update on record keeping
Authors: Mortiboy Kate
Published: October 2022

Dentists are required to make and keep accurate dental records of care provided to their patients. As such, dentists should familiarize themselves with data protection legislation and how that impacts their practice. This article discusses the benefits of good record keeping, the use of templates in record keeping, access to and retention of dental records and the benefit of audit to ensure record keeping is meeting current standards.

CPD/Clinical Relevance: An update and overview for the dental team on record keeping and the relevant standards.
Modelling MODIS Land Surface Temperature Change in Antarctica from 2000 to 2019 Using Cubic Spline Model
Authors:   Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, 94000, Thailand, Dengmasa Maleekee , Tongkumchum Phattrawan ,   Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, 94000, Thailand, Ma-A-Lee Arinda ,   Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, 94000, Thailand
Published: October 2022

Abstract Land surface temperature (LST) data derived from the satellite is increasingly required to supplement the limited weather stations for assessing temperature trends in Antarctica. This study analyses the LST based on data from the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard NASA’s satellite length from 2000 to 2019 at a systematic 108 sub-regions. Antarctica was divided into 12 regions, each consisting of 9 sub-regions. A cubic spline model adjusted for seasonal patterns and the autoregressive process adjusted for time series correlation. Change in LST in sub-regions was estimated by fitting the simple linear model, while cycle and acceleration were estimated using cubic spline models. Multivariate regression adjusted for spatial correlation and was used to estimate the LST increase in regions. The seasonal patterns for all 108 sub-regions were found to be quite similar. Out of 108 sub-regions, only 30 had statistically significant decreasing trends. The 12 regions showed that most temperature trends decreased, although only 5 regions were statistically significant. The results for the entire Antarctic continent showed a statistically significant decrease and a 95% confidence interval ranging from -0.668 to -0.068 °C per decade. Keywords: Land surface temperature, MODIS, Cubic spline, Autocorrelations, Spatial correlations
Effects of Plasma Treatment on Chemical and Physical Properties of Pigmented Rice Flour
Authors:   Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand, Liamlaem Sirintat , Naruenartwongsakul Srisuwan ,   Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand,   Lanna Rice Research Center, Chiang Mai University, Chiang Mai 50200, Thailand, Intipunya Pilairuk ,   Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand,   Lanna Rice Research Center, Chiang Mai University, Chiang Mai 50200, Thailand
Published: October 2022

Abstract The objective of this research was to study the effects of plasma treatment at different power levels (100, 120, and 140 W) and exposure times (5, 10, and 15 min) on the physical and chemical properties of pigmented rice flours from Kum Doi Saket cultivar. An increase in plasma power and exposure time resulted in decreases of moisture contents, solubility, and swelling power of the rice flour, while the resistant starch content was increased. The amylose content tended to decrease when plasma power and exposure time was increased. In this study, plasma treatment at 140 W for 10 min maintained the highest anthocyanin content in Kum Doi Saket rice flour (68.35 – 98.63 mg/100 g). Pasting property analysis by RVA revealed decreases in peak viscosity, breakdown and setback viscosities. The pasting temperature of Kum Doi Saket rice flour was significantly decreased (P ≤0.05) after plasma treatment. Plasma treatment did not affect the onset temperature (To) and ΔH of starch gelatinization as analyzed by a DSC, while peak temperature (Tp) and end set temperature (Te) of flour sample were increased (P ≤0.05). Plasma effects on size, shape and surface roughness of flours were observed by SEM. Higher plasma power and treatment time caused more micro-pores on the surface of flour particles, especially after being treated at 140 W for 15 min. Keywords: Pigmented rice flour, Cold plasma technology, Flour properties, Cross-linking
Sinapyl alcohols analogues from the stembark of Zanthoxylum rhetsa (Roxb.) DC and their cytotoxic activity against MCF-7 breast cancer cell line
Authors:   Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang,   Indonesia, . Ruchiyat ,   Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Garut, Garut, 44111, Indonesia, Herlina Tati ,   Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang,   Indonesia, Musthapa Iqbal ,   Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Garut, Garut, 44111, Indonesia,   Department of Chemistry, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi Bandung, 40141, Indonesia, Supratman Unang ,   Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang,   Indonesia,   Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia
Published: October 2022

Abstract Three sinapyl alcohol analogues, 4-O-[(2E)-3,7,7-Trimethyl-2,6-octadiene] (1), 4-O-[(2E)-3,7-Dimethyl-2,7-octadiene-6-ol] (2) and 4-O-[(2E)(5E)-3,7,7-Trimethyl-2,5-octadiene-7-ol] (3) have been isolated from the stem bark of Zanthoxylum rhetsa (Roxb.) DC (Rutaceae). The chemical structures of compounds 1-3 were determined based on spectroscopic data including one and two-dimensional NMR, and mass spectroscopy. Cytotoxic activity against MCF-7 breast cancer cell lines was tested in vitro using these sinapyl alcohols. Among the isolated compounds 1, showed the strongest activity with an IC50 value of 54.18 µg/mL, suggesting that the presence of a gem-dimethyl and hydroxyl groups play important role for cytotoxic activity. Keywords: Cytotoxic activity, MCF-7 cell lines, Rutaceae, sinapyl alcohol, Zanthoxylum rhetsa (Roxb.) DC.