bluuebunny/crossref_metadata_2025 huggingface dataset:
ACUTE TOXICITY TEST LD50 COMPLEX Fe(II)N-BENZYLMETHYL DITHIOCARBAMATE IN WHITE MICE (Mus muscle)
Authors: Sanuddin Mukhlis , Meirista Indri , Kinanti Ranny Adia
Published: May 2023

A toxicity test is a test carried out to estimate the degree of damage caused by a compound to biological or non-biological materials. One of the compounds known to have anticancer, antibacterial, and antifungal effects is Fe(II) N-benzyl methyl dithiocarbamate. This compound has cytotoxic activity on liver cells. The purpose of this study was to determine the LD50 value of Fe (II) N-benzyl methyl Dithiocarbamate and to determine the acute toxicity category of Fe (II) N-benzyl methyl Dithiocarbamate. From the results of research that have been carried out the synthesis of compounds capable of forming complex compounds of Fe (II) N-benzylmethyl dithiocarbamate which causes no death in male and female mice with an unknown LD50 value, categorized as non-toxic, meaning that this complex compound does not have a toxic effect on male mice. and female.
A Chronic Case of Hepatosplenomegaly in Elderly Diabetic Male
Authors: Sarella Prakash Nathaniel Kumar , Pilla UmaVenkata Anusha , Asogwa Patrick Oliver , Kakarparthy Ravishankar
Published: May 2023

This case report presents the case of a 65 year-old male with a longstanding history of type 1 diabetes of 45 years duration. His diabetes was poorly controlled, as evidenced by the development of complications including hepatosplenomegaly and anemia. The patient presented with constitutional symptoms of fatigue, abdominal fullness and early satiety. His laboratory investigations revealed anemia with a hemoglobin of 11.5 gm% and a reduced red blood cell count. Ultrasonography showed hepatosplenomegaly with minimal ascites. A wide differential diagnosis for hepatosplenomegaly was considered, including infectious, hematological and autoimmune causes. However, in this patient with longstanding diabetes, the most likely etiology was diabetic microangiopathy leading to portal hypertension and congestion of the liver and spleen. Thorough diagnostic workup was performed to rule out other potential causes of hepatosplenomegaly. The management approach focused on improving glucose control to slow the progression of microvascular complications. Optimization of medications and lifestyle modifications were initiated. Monitoring for complications of portal hypertension such as variceal bleeding and ascites was instituted.
Too Old or Too Young – Does Population Ageing Matter for Inflation?
Authors: EN MA SHI , CHEONG TANG TUCK
Published: May 2023

This study ascertains the impact of population ageing on inflation more comprehensively
by an unbalanced panel data of 125 countries spanning between 1996 and 2019. This
study contributes a more generalized evidence of the impact of population ageing, and
institutional quality on inflation region-wise. The control variables are those conventionally employed in explaining the inflation behaviour, namely real GDP, real interest rate, broad money growth, and imports. The empirical results are based on the panel fixed effects model by Ordinary Least Squares (OLS) estimator with Cross-section Seemingly Unrelated Regression (SUR) Panel-Corrected Standard Errors (PCSE). This study finds that population ageing is deflationary. However, higher inflation is associated with increases in young dependents. The mediating effect of good institution on ageing to inflation is deflationary, while opposite holds given a weak institution. These findings vary among the seven different geographical regions. Indeed, this study is feasible for policymakers from both monetary and fiscal perspectives as well as social security.
Let Us Create an Alexa Skill for Our IoT Device Inside the AWS Cloud
Authors: Chakraborty Sudip , Aithal P. S.
Published: May 2023

Purpose: The Internet of Things (IoT) has changed how we interact with technology, allowing us to control and monitor devices remotely from our smartphones or other devices. One of the most popular ways of interacting with IoT devices is through voice assistants like Amazon Alexa. To integrate an IoT device with Alexa, developers must create a custom Alexa skill to understand voice commands and communicate with the IoT device. This research paper presents a practical guide for developers interested in creating custom Alexa skills for their IoT devices. It covers the essential steps in setting up the AWS IoT platform, designing the Alexa skill's interaction model, and testing the Skill.
Design/Methodology/Approach: We decided which load or equipment would be operated using the Alexa voice command. Then we thought about quickly consuming minimal words for each device operation. We prepared the command list in the Excel sheet and a command prototype for Alexa utterances. We created an AWS account in the AWS cloud server and started to create the new Skill. Finally, we must add the AWS lambda function ARN to the Alexa default Endpoint to update the IoT Device shadow for connected devices.
Findings/Result: This research demonstrates that the development of an Alexa skill for IoT devices in the AWS Cloud is a reliable, efficient, and flexible approach that has the potential to revolutionize the way we interact with IoT devices in our daily lives.
Originality/value: The novelty of this research lies in the fact that it provides a step-by-step guide to developing an Alexa skill for IoT devices in the AWS Cloud. It will also help researchers and developers understand the complexities of developing Alexa skills for IoT devices in the AWS Cloud and how these skills can be used to control IoT devices anywhere. This research will add value to the field by providing developers with the necessary tools and techniques to develop sophisticated and reliable Alexa skills for IoT devices in the AWS Cloud.
Paper Type: Experimental-based Research.
Makeover of Banks by Digital Interventions and Innovations by Fintechs
Authors: B. S. Anupa Baliga , Goveas Carmelita
Published: May 2023

Background/Purpose: The global economy is continuously changing with innovation and technological development. In the recent past, digital technology has revolutionized the banking sector and hence banks are readjusting their business strategies toward e-banking. Fintech companies with lower costs operations were taking over the banking business initially, and now are partnering with banks to increase their profits and customer base.
Design/Methodology/Approach: The data for this case study has been gathered from secondary sources of information by referring to a number of research articles in journals and information from the internet. It is a case study research approach that seeks to assess fintech and banking digital transformation and aims to evaluate Fintech in Banking using SWOC analysis.
Findings: Banks by partnering with fintech companies can expand their services instantaneously using data sets. It can offer a single platform to access various financial services and also introduce innovative, economical products, and services to customers. Integration of banks with fintech may lead to technical complexity. It is challenging to meet the rising expectations of the customers.
Originality/Value: This paper analyses the role of fintech in banking and provides suggestions through evaluation.
Paper Type: Case Study Research paper
Mulheres quilombolas:
Authors: Barros Fabio Junior da Luz
Published: May 2023

Esta resenha examina o livro: Mulheres quilombolas: território de existências negras femininas (2020), o qual tem como autoras 12 mulheres quilombolas de diversas regiões do Brasil e de várias áreas do conhecimento formal e informal. A escrita pretende analisar a luta, a resistência e os problemas que as mulheres quilombolas enfrentam no Brasil. A resenha é fruto de uma pesquisa bibliográfica feita no referido livro, organizado por Selma dos Santos Dealdina. Com base na leitura que fiz, ficou evidente o sofrimento e as lutas vivenciadas pelas mulheres quilombolas de todas as regiões do país, por outro lado, elas marcaram no texto que, via várias lutas, estão, ainda que de forma lenta, conseguindo ser incluídas em cargos da política sindical, nas associações, nas universidades, etc., ou seja, ocupando posições importantes socialmente.
Sem Referências: o ChatGPT sob a perspectiva latouriana e a armadilha do Duplo Clique
Authors: Rodrigues Catalano José Victor , Rossi Lorenzi Bruno
Published: May 2023

A Inteligência Artificial Generativa tem despertado grande interesse na população, e o ChatGPT é um exemplo notável desse fenômeno, devido à sua ampla cobertura midiática. Entretanto, ao analisarmos as principais controvérsias em torno da versão 3.5 do ChatGPT, fica evidente que a ausência de referências confiáveis é um problema alarmante. Em alguns casos, a ferramenta gera informações imprecisas ou falsas, que alguns autores chamam de 'alucinações'. Este artigo foca na problemática das fontes e referências, que o ChatGPT frequentemente não fornece e, em alguns casos, até falsifica. Com a crescente disseminação do uso da ferramenta, a questão da falta de fontes e ou referências pode se tornar ainda mais grave. Os usuários podem considerar o ChatGPT como um oráculo infalível, aumentando sua confiabilidade pelo simples hábito de uso. Nesse sentido, analisamos esse comportamento à luz do conceito de Duplo Clique, presente na obra 'Investigação sobre os modos de existência: Uma antropologia dos modernos', de Bruno Latour. Abordando a ignorância das mediações durante o processo de conversação (saídas) com a IA e seus possíveis efeitos para a sociedade, caso acreditar cegamente em saídas com falta de referências (um duplo clique) se torne um hábito.
Vehicle Air Pollution and SMS Alert
Authors: Ashish Raj Mall  , Kumar Satyam  , Raghav Mittal  , Madhu Verma
Published: May 2023

Vehicle air pollution is a major issue worldwide, with adverse effects on human health and the environment. In recent years, researchers have developed various strategies to reduce vehicle air pollution, such as introducing electric vehicles, carpooling, and improving public transportation. However, the effectiveness of these strategies is limited due to several factors, including lack of awareness and behavioural change among drivers. The results of the study show that the SMS alert system has a significant impact on reducing vehicle air pollution. The intervention group showed a 30% reduction in vehicle emissions compared to the control group. The findings of this research paper suggest that an SMS alert system can be an effective strategy to reduce vehicle air pollution and promote sustainable transportation practice.
Impact of O2 Content on the Corrosion Behavior of X65 Mild Steel in the Gaseous, Liquid, and Supercritical CO2 Streams
Authors: Jiang Xiu , Song Xiaoliang , Qu Dingrong , Hua Jing , Yu Chao
Published: May 2023

The CO2 stream in a carbon capture utilization and storage application generally includes impurities that could cause internal corrosion of CO2 pipelines. The general and localized corrosion behavior with a variety of O2 concentrations for X65 mild steel both in water-saturated CO2 and CO2-saturated water environments was evaluated using an autoclave. Corrosion tests were performed at 8 MPa and 25°C, 8 MPa and 35°C, and 4 MPa and 35°C to simulate the liquid, supercritical, and gaseous CO2 transportation. Results indicate that notably higher general corrosion rates were recorded at each O2 concentration in the CO2-saturated water phase than those in the water-saturated CO2 environment. The general corrosion rates did not show gradual rise at 0 ppm to 2,000 ppm of O2; instead, a maximum was measured at 1,000 ppm of O2 at 8 MPa and 25°C, and 50 ppm O2 at 8 MPa and 35°C in the water-saturated CO2 environment and 50 ppm at 8 MPa and 25°C, and 100 ppm at 8 MPa and 35°C in the CO2-saturated water environment. The general corrosion rate at 4 MPa and 35°C followed a different changing trend with O2 content from that in 8 MPa, and 25°C and 35°C both in the water-saturated CO2 and the CO2-saturated water environments. Localized corrosion or an average corrosion rate of beyond 0.1 mm/y was identified in each test in the CO2-saturated water environment. When O2 was introduced, a more porous corrosion product scale was detected on the coupon surfaces. A final series of corrosion tests with 100 ppm and 2,000 ppm O2 and 60% and 80% relative humidity in a CO2 environment did not show any sign of localized corrosion attack, and the average corrosion rates were below 0.1 mm/y at 8 MPa, 25°C and 35°C, and 4 MPa and 35°C.
Impact of Fireside Corrosion on the Creep Rupture Life and Oxide Scale Structure of a Super304H Boiler Tube
Authors: Yang Xiaofeng , Xu Yaxin , Chen Wenxue , Lu Jintao , Dang Yingying , Huang Jinyang , Li Wenya
Published: May 2023

The creep rupture life of commercial Super304H in fireside corrosion (coal ash and flue gas) and static air environment at 650°C was investigated. Results showed that the creep rupture life under fireside corrosion conditions decreases by 26.5% to 83.3% at different stress levels, compared with that in air. The corrosion products, including their composition, morphology, and distribution, and the microstructure of substrate were characterized to research the impact of the fireside corrosion on the creep rupture life. The exfoliation of oxide scales and serious surface cracking resulted from fireside corrosion were detrimental for the creep properties of the alloy. The formation of internal sulfides promoted the initiation and propagation of intergranular cracks in the substrate during creep tests. These degradations of Super304H in fireside corrosion contributed to premature creep rupture.
Uma semântica Informacional para a consequência lógica
Authors: Alves Marcos Antonio
Published: May 2023

Em termos semânticos, a consequência lógica é definida costumeiramente a partir do valor de verdade das premissas e conclusão: esta é verdadeira em toda situação na qual aquelas o sejam. Pode-se entender que, nestes casos, a conclusão não contém mais informação do que o conjunto de premissas. Com base nesta ideia, desenvolvemos, neste artigo, uma definição de consequência lógica informacional, baseada na noção de informação sugerida na Teoria Matemática da Comunicação. Mostramos alguns resultados, tais como que, apesar de inconsistente, o sistema subjacente a essa noção não é trivial e que a lógica subjacente à consequência lógica informacional não é clássica, mas algum tipo de lógica paraconsistente.
Períodos compostos por subordinação: uma proposta de intervenção com jogos pedagógicos
Authors: Lima Rafael Bezerra de , Santos Vanicléia Lima dos
Published: May 2023

O trabalho aqui proposto apresenta resultados obtidos a partir de uma intervenção com jogos pedagógicos para o ensino dos períodos compostos por subordinação em turmas do 9º ano. Para isso, baseamo-nos nos estudos gramaticais de Travaglia (2008); refletimos sobre a Sintaxe com Ferrarezi Junior (2012); Kenedy e Othero (2018); e na área dos jogos pedagógicos, utilizamos autores como Ide (2009); Pilati (2017) e Kishimoto (2009). Como metodologia, trata-se de uma pesquisa-ação, com abordagem predominantemente qualitativa e método indutivo (MARCONI; LAKATOS, 2003). Constatamos, então, que o ensino de estruturas gramaticais mostrou-se eficaz se atrelado a materiais concretos, como os jogos pedagógicos, pois estes não são apenas capazes de desenvolver um método lúdico no ensino, mas, sobretudo, de aprimorar a aprendizagem cognitiva, estimulando o raciocínio dos alunos em relação à gramática.
Schopenhauer: Manuscript Remains (V3)
Authors: Schopenhauer Arthur
Published: May 2023

This historico-critical edition of Schopenhauer's manuscript remains contains Schopenhauer's entire surviving philosophical notes, from his university years until his death in 1860. Translated here into English for the first time, it provides a fascinating insight into the workings of Schopenhauer's mind and an important key to his philosophical work. Translated by E.F.J. Payne
State–society relations before and
after the Revolution
Authors: Sigillò Ester
Published: May 2023

This chapter brings to light the fundamental continuities and changes in
state-society’s power relations in Tunisia from the years of French colonial
domination until the revolution. The chapter is divided into two main
sections. The first part describes in depth the mechanisms of co-optation
of civil society actors under the authoritarian regimes of Habib Bourguiba
(1956–1987) and Zine-El Abidine Ben Ali (1987–2011), highlighting the role
of associations as tools of state control over Tunisian society. The second
part highlights the main legal transformations introduced after 2011 that
made it easier for new associations to register legally. The rise of thousands
of social solidarity and development associations went hand in hand with
the state’s continued disengagement from the socioeconomic sphere.
Civil society as an arena: networking
strategies beyond hegemonic actors
Authors: Sigillò Ester
Published: May 2023

The chapter is divided into three sections, describing how and why three
socio-political groups neglected during the Ben Ali’s regime have engaged
in the associational system. The first section describes the nature of power
relations in the social solidarity economy ecosystem in marginalized areas
of the country, where local NGOs experts act as pivotal actors. The second
section highlights the rising urban middle-classes previously excluded
from the political game and now looking for new partnerships with local
institutions at the sub-national level. The third section is focused on the
reorganization of Islamic networks under the new frame of professionalization.
As we will see, different forms of civic engagement ultimately reveal
a reconfiguration of power relations.
Waterland and the Disquiet of the Dutch
Landscape
Authors: Mochizuki Mia M.
Published: May 2023

Although the shift in how land was portrayed circa 1600 has mainly been
understood through the dynamics of earth in land-centric terms, water also
positioned the coastline as a zone of artistic invention through the etymology
of the independent landscape picture, the physical sites of the polders of the
Netherlands, and the tradition of approaching land from the sea. By taking a
water-oriented view of land, the famously low horizon line of the Dutch landscape
can be explained by the chorographic and cosmographic visual conventions of
nautical navigation tools—portolan chart and rutter, astrolabe and globe—that
made land recognizable to contemporaries as an image, and by prefacing risk over
realism, ushered in the disquiet of the Dutch landscape.
Authoritarian Audiences: Theory and Evidence for Subnational Propaganda Targeting in North Korea
Authors: Ba Heather-Leigh K. , Greitens Sheena Chestnut , Kim Yu Bin
Published: May 2023

We argue that authoritarian regimes engage in subnational propaganda targeting in pursuit of political survival. Drawing on an original dataset of propaganda collected inside North Korea, we show that the regime tailors messaging to elites and masses differently. We outline a schema of strategies and themes that authoritarian regimes utilize when crafting propaganda, theorize variations in their use, and test these variations empirically, using qualitative analysis, regression, and text analysis. We demonstrate that the North Korean regime targets Pyongyang-based elites with co-optational messages promising economic benefit, while the masses receive mobilizational messages focused on agricultural productivity. North Korean propaganda also legitimates the regime differently based on audience: messages to elites reassure them of their privileged status but messages to the masses remind them of why their sacrifices are necessary.
KẾT QUẢ BÓC NHÂN PHÌ ĐẠI LÀNH TÍNH TUYẾN TIỀN LIỆT NỘI SOI QUA NIỆU ĐẠO BẰNG HOLMIUM-LASER TẠI BỆNH VIỆN HỮU NGHỊ VIỆT ĐỨC
Authors: Đỗ Trường Thành , Ngô Đậu Quyền , Nguyễn Đạo Uyên
Published: May 2023

Mục đích: Trong nghiên cứu này chúng tôi áp dụng kỹ thuật bóc nhân phì đại lành tính tuyến tiền liệt nội soi qua đường niệu đạo theo phương pháp 1 khối cải tiến và đánh giá tính an toàn, kết quả sớm của phẫu thuật bóc nhân phì đại lành tính tuyến tiền liệt theo phương pháp bóc nhân một khối. 2. Phương pháp nghiên cứu: chúng tôi nghiên cứu tiến cứu trên 258 bệnh nhân rối loạn tiểu tiện do u phì đại lành tính tuyến tiền liệt, được phẫu thuật bóc nhân phì đại bằng laser Holmium từ tháng 1/2020 đến tháng 1/2022. Kỹ thuật phẫu thuật bóc nhân phì đại 1 khối cải tiến được thực hiện bằng 2 đường rạch ở vị trí 12h và 6h. Trong mổ chúng tôi đánh giá thời gian bóc nhân phì đại, thời gian say nhỏ và lấy bệnh phẩm ra ngoài. Lượng máu mất, các tai biến trong mổ. Các thông số sau mổ bao gồm: thời gian đặt ống thông niệu đạo, thời gian nằm viện. Tình trạng tiểu tiện sau mổ. Các biến chứng sau mổ được đánh giá theo phân độ của Clavien–Dindo. Bệnh nhân được đánh giá theo dõi ở thời điểm 3 tháng sau mổ. 3. Kết quả nghiên cứu: tuổi trung bình của nhóm bệnh nhân nghiên cứu là 74,51. Trọng lượng trung bình tuyến tiền liệt là 77,54g. Lượng PSA trung bình là 8,23ng/ml. Điểm IPSS trước mổ trung bình là 25,27. Thời gian mổ trung bình là 72,55 phút, trong đó thời gian bóc nhân phì đại là 50,76 phút, thời gian say bệnh phẩm là 18,55 phút. Lượng máu mất trong mổ trung bình là 7,26g/l. Trong mổ có 8 bệnh nhân chảy máu nặng phải truyền máu. Thời gian đặt ống thông niệu đạo trung bình là 4,55 ngày, thời gian nằm viện trung bình là 5,31 ngày. Sau mổ có 18 (6,97%) bệnh nhân bí đái phải đặt lại ống thông niệu đạo. 32 bệnh nhân đái không tự chủ khi thay đổi tự thế (12,40%). Sau 3 tháng 229 (88,75%) bệnh nhân tiểu tiện bình thường, tự chủ. Không có biến chứng nặng sau mổ. 29 bệnh nhân còn đái rỉ gắng sức (11,24%). Điểm IPSS sau mổ trung bình là 4,27 ± 3,7. Trọng lượng TTL xác định trên siêu âm sau mổ là 22,50 ± 2,5g. 4. Kết luận: quy trình bóc nhân phì đại lành tính tuyến tiền liệt một khối, thực hiện bằng hai đường rạch ngang ở vị trí 6h và đường dọc ở 12h bằng laser Holmium là phẫu thuật an toàn dễ thực hiện và có hiệu quả với mọi kích thước của u phì đại lành tính tuyến tiền liệt.
KẾT QUẢ PHẪU THUẬT NỘI SOI ĐIỀU TRỊ SỎI ĐƯỜNG MẬT CHÍNH MỔ LẠI CÓ SỬ DỤNG NỘI SOI ĐƯỜNG MẬT VÀ ỐNG NỐI MẬT - DA
Authors: Lê Văn Thành , Lê Văn Lợi
Published: May 2023

Mục tiêu: Đánh giá kết quả phẫu thuật nội soi điều trị sỏi đường mật chính mổ lại có sử dụng nội soi đường mật và ống nối mật - da. Đối tượng và phương pháp: nghiên cứu tiến cứu, không đối chứng 48 bệnh nhân được phẫu thuật nội soi điều trị sỏi đường mật chính mổ lại có sử dụng nội soi đường mật và ống nối mật - da. Kết quả: Tỷ lệ phẫu thuật thành công 100%. Tỷ lệ sạch sỏi sau mổ là 66,7%. Tai biến 2,1%. Thời gian mổ trung bình là 137,3 ± 28,1 (phút), thời gian lấy sỏi trung bình là 54,6 ± 26,2 (phút). Biến chứng sớm sau mổ 10,4% Thời gian nằm viện sau mổ là 6,5 ± 2,7 (ngày). Kết luận: phẫu thuật nội soi điều trị sỏi đường mật chính mổ lại có sử dụng nội soi đường mật và ống nối mật - da là phương pháp an toàn và hiệu quả.
NGHIÊN CỨU ĐẶC ĐIỂM BỆNH NHÂN UNG THƯ VÚ GIAI ĐOẠN SỚM ĐIỀU TRỊ NỘI TIẾT TẠI BỆNH VIỆN QUÂN Y 175
Authors: Huỳnh Thị Thanh Giang , Nguyễn Hồng Hoa , Nguyễn Minh Tân , Nguyễn Văn Hữu , Nguyễn Thị Thắm , Tống Vân Anh , Nguyễn Thị Dung , Nguyễn Tiến Dũng , Nguyễn Thị Huyền Trang , Trịnh Hồng Hạnh , Ngô Đăng Hưởng , Lê Thanh Thượng , Nguyễn Thị Yến
Published: May 2023

Mục tiêu nghiên cứu: Xác định đặc điểm bệnh nhân ung thư vú giai đoạn điều trị nội tiết đến khám tại Trung tâm Ung bướu Bệnh viện Quân Y 175. Phương pháp nghiên cứu: Thiết kế nghiên cứu mô tả loạt ca khảo sát 105 người bệnh mắc ung thư vú giai đoạn sớm được điều trị nội tiết tại bệnh viện quân Y 175 từ 01/12/2021 đến 30/05/2022. Kết quả: Tuổi trung bình 54,8 ± 10,4 tuổi. Phân loại mô bệnh học theo Grad nhóm II chiếm 80% và nhóm I 17,1%. Nhóm III chỉ 2,9%. HER-2 dương tính chiếm 13,3%. Giai đoạn ung thư vú phổ biến nhất là IIA chiếm 61,9%. Trong đó giai đoạn từ IIB (8,6%) và IIIA (2,9%). Kết quả giải phẫu bệnh trong chủ yếu là Carcinoma OTV chiếm 82,9% và Carcinoma tuyến vú chiếm 10,4%. Người bệnh được hóa trị trước điều trị nội tiết 77,1%. Người bệnh có xạ trị chiếm 70,5%. Các thuốc nội tiết đã sử dụng trong đó Tamoxifen (50,5%) và Ais (49,5%) Sử dụng thuốc ức chế buồng trứng nội khoa 25,7%. Thời gian sử dụng thuốc nội tiết trung bình 32,5 ± 22,5 tháng. Kết luận: Điều trị nội tiết bổ trợ làm giảm đáng kể nguy cơ tái phát ung thư vú, tăng khả năng điều trị khỏi, tuy nhiên phải xem xét tác dụng phụ không mong muốn đối với sức khỏe hệ xương.
NGHIÊN CỨU ĐA HÌNH GEN STAT5B RS6503691 Ở BỆNH NHÂN UNG THƯ BIỂU MÔ TẾ BÀO GAN CÓ HBSAG (+)
Authors: Lê Quang Nhựt , Nguyễn Xuân Kiên , Dương Quang Huy
Published: May 2023

Mục tiêu: Xác định tần suất kiểu gen của điểm đa hình gen STAT5b rs6503961 và mối liên quan với nguy cơ ung thư ở bệnh nhân ung thư biểu mô (UTBM) tế bào gan. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 118 bệnh nhân UTBM tế bào gan có HBsAg (+), có so sánh với 86 bệnh nhân xơ gan có HBsAg (+) và 195 người khỏe mạnh tại Bệnh viện TWQĐ 108, Bệnh viện Quân y 103 và Bệnh viện Đa khoa thành phố Cần Thơ thời gian từ 7/2017 đến 8/2020. Tiến hành phân tích đa hình gen STAT5b rs6503691 từ mẫu máu ngoại vi của các đối tượng nghiên cứu theo phương pháp PCR-RFLP tại Trung tâm nghiên cứu y dược học Quân sự - Học viện Quân y. Kết quả: Tần xuất kiểu gen CC của điểm đa hình gen STAT5b rs6503691 chiếm tỷ lệ cao nhất ở bệnh nhân UTBM tế bào gan là 49,7%, cao hơn so chỉ số tương ứng ở nhóm xơ gan là 47,7% và người khỏe mạnh là 40,5%; trong khi kiểu gen TT chiếm thấp nhất ở bệnh nhân xơ gan (7,0%), sự khác biệt chưa có ý nghĩa thống kê, p > 0,05. Kết luận: Đa hình gen STAT5b rs6503691 không có mối liên quan đến nguy cơ UTBM tế bào gan có HBsAg (+).
PHÂN TÍCH HIỆU QUẢ CAN THIỆP CỦA CHƯƠNG TRÌNH QUẢN LÝ SỬ DỤNG KHÁNG SINH COLISTIN TẠI BỆNH VIỆN HỮU NGHỊ VIỆT ĐỨC
Authors: Nguyễn Thanh Hiền , Nguyễn Thị Tuyến , Lê Thị Minh Hằng , Nguyễn Hoàng Anh , Nguyễn Hoàng Anh , Lưu Quang Thùy
Published: May 2023

Mục tiêu: Phân tích tác động của Hướng dẫn sử dụng colistin đến việc sử dụng kháng sinh này tại Bệnh viện Hữu Nghị Việt Đức. Đối tượng và phương pháp: nghiên cứu can thiệp thông qua hoạt động Dược lâm sàng theo dõi dọc hồ sơ bệnh án của bệnh nhân sử dụng colistin trong giai đoạn tháng 04-06/2021 (trước can thiệp), và bệnh nhân có phiếu yêu cầu sử dụng colistin trong giai đoạn tháng 08-10/2022 (can thiệp). Kết quả: Tất cả các phiếu yêu cầu sử dụng colistin đều được dược sĩ lâm sàng xem xét duyệt, với tổng số 253 can thiệp đã được thực hiện, tỷ lệ chấp thuận đạt 52,2% trong 3 tháng. Colistin đã được chú ý chỉ sử dụng cho các nhiễm khuẩn nặng do vi khuẩn đa kháng gây ra. Tỷ lệ phù hợp về chỉ định trong hai giai đoạn nghiên cứu không khác biệt có ý nghĩa thống kê và tương đối cao, lần lượt là 99,2% và 100%. Tỷ lệ sử dụng liều nạp, mức liều nạp, liều duy trì và giám sát chức năng thận trong quá trình điều trị phù hợp với Hướng dẫn được cải thiện đáng kể, với tỷ lệ 77,3%; 20,5%; 26,5% và 53,0% giai đoạn trước can thiệp đã tăng lên đáng kể, tương ứng 99,5%; 70,1%; 63,1%, 72,6% trong giai đoạn can thiệp (p<0,001). Phần lớn liều dùng không phù hợp do mức liều thấp hơn khuyến cáo. Kết luận: Kết quả nghiên cứu cho thấy tác động tích cực của chương trình quản lý kháng sinh thông qua hoạt động Dược lâm sàng đến việc sử dụng colistin tại Bệnh viện. Cần tiếp tục tăng cường tập huấn và trao đổi chuyên môn về liều dùng colistin để đảm bảo bệnh nhân sử dụng mức liều tối ưu hơn.
KHẢO SÁT CÂY CÀ ĐẮNG (SOLANUM INCANUM L.) THU HÁI TẠI ĐẮK LẮK THEO HƯỚNG TÁC DỤNG CHỐNG OXY HÓA
Authors: Phạm Thị Phương , Liêu Hồ Mỹ Trang , Lê Thị Hồng Vân , Huỳnh Ngọc Thụy
Published: May 2023

Mẫu nghiên cứu cây Cà đắng thu hái tại Đắk Lắk, qua kết quả phân tích hình thái, giải phẫu thực vật, đối chiếu với tài liệu tham khảo đã xác định tên khoa học của nguyên liệu nghiên cứu là Solanum incanum L.. Đánh giá hoạt tính chống oxy hóa của dịch chiết phân đoạn bằng phương pháp DPPH và xanthin oxidase, kết quả chiết xuất cồn 96% của hoa, quả xanh, quả chín vàng và phân đoạn ethyl axetat cho thấy hoạt tính chống oxy hóa mạnh ở nồng độ 62,5 µg/ml. Đây là kết quả công bố đầu tiên đã xác định được tên khoa học và hoạt tính chống oxy hóa của Cà đắng, cung cấp cơ sở dữ liệu ban đầu về nghiên cứu và phát triển dược liệu của tỉnh Đắk Lắk
PENGARUH EDUKASI MELALUI MEDIA AUDIO VISUAL TERHADAP PENGETAHUAN PASIEN HIPERTENSI DI PUSKESMAS SAMBIREJO
Authors: Novrianti Elsa , Ikhsan Ikhsan , Rahmawati Suci
Published: May 2023

Pengetahuan pasien tentang hipertensi penting untuk menentukan langkah pencegahan serta pengobatan hipertensi. Tingkat pengetahuan yang tinggi dapat mempengaruhi keberhasilan pengobatan hipertensi. Media audiovisual merupakan media edukasi yang memiliki efektivitas yang baik untuk meningkatkan pengetahuan karena merangsang lebih banyak indera. Desain penelitian menggunakan rancangan one group  pre test and post test dengan jumlah sampel penelitian 63 orang. Instrument penelitian yang digunakan adalah video tentang hipertensi dan kuesioner pengetahuan hipertensi Hypertension Fact Quisionnare (HFQ). Hasil penelitian dianalisis secara statistik menggunakan uji testData diolah secara analisis univariat dan bivariat Hasil penelitian dari 63 responden didapatkan rata-rata tingkat pengetahuan pasien sebelum diberikan edukasi adalah sebesar 6,95 dan rata-rata tingkat pengetahuan setelah diberikan edukasi adalah sebesar 9,10 dan didapatkan hasil p value 0,001(<0,05) yang artinya ada pengaruh yang signifikan antara tingkat pengetahuan pasien hipertensi sebelum dan sesudah diberikan edukasi melalui media audio visual di Puskesmas Sambirejo.

Kata Kunci : Hipertensi, Pengetahuan, Media audiovisual

 

 

 

ABSTRACT

Patient knowledge about hypertension is important to determine steps to prevent and treat hypertension. A high level of knowledge can affect the success of hypertension treatment. Audiovisual media is an educational medium that has good effectiveness for increasing knowledge because it stimulates more senses. This study used a one group pre test and post test design with a total sample of 63 people. The research instrument used was a video about hypertension and a hypertension knowledge questionnaire. Hypertension Fact Questionnare (HFQ). The results of the study were analyzed statistically using a test test. The results of the study from 63 respondents obtained that the average level of knowledge of patients before being given education was 6.95 and the average level of knowledge after being given education was 9.10 and the p value was 0.001 (<0.05), which means that there is an effect There was a significant difference between the knowledge level of hypertension patients before and after being given education through audio-visual media at the Sambirejo Health Center.
Keywords: Hypertension, Knowledge, Audiovisual Media
KARAKTERISTIK KUALITAS AIR SUMUR GALI DI KECAMATAN MUARA BANGKAHULU MELALUI ANALISIS DATA DAYA HANTAR LISTRIK, TOTAL DISSOLVED SOLID (TDS), pH, dan SUHU
Authors: Adeko Riang , Ermayendri Defi , Andriana Marwanto Andriana
Published: May 2023

Latar Belakang : Pemenuhan kebutuhan air baku domestik masyarakat di Indonesia semakin lama semakin meningkat dengan dibarengi laju pertumbuhan penduduk yang begitu besar. Eksploitasi secara besar-besaran air tanah dangkal dalam hal ini sumur gali berdampak pada menurunnya kualitas air baku tersebut yang ditandai dengan adanya penurunan muka air tanah dan intrusi air laut. Penelitian ini menitikberatkan pada sebaran karakteristik kualitas air sumur gali di Kecamatan Muara Bangkahulu Kota Bengkulu

Metode : Penelitian ini membagi 2 metode yaitu metode systematic random sampling (penentuan sampel secara acak sistematik) dan metode cluster sampling atau area sampling. Metode ini digunakan untuk menentukan sampel yang akan diukur daya hantar listrik air tanahnya,TDS, Ph,dan suhu dengan lokasi sampel ditentukan secara acak berdasarkan area kelas kedalaman muka air tanah daerah penelitian.

Hasil : Suhu air sumur gali Kecamatan Muara Bangkahulu termasuk kategori aman dengan suhu 27° C – 29 °C, Total Disolved Solid (TDS) air sumur gali Kecamatan Muara Bangkahulu termasuk kategori aman dengan rata-rata TDS 26,58 ppm, Daya Hantar Listrik (DHL) air sumur gali Kecamatan Muara Bangkahulu termasuk kategori aman dengan rata-rata DHL 27,71 μmhos/cm, Derajat Keasaman (pH) air sumur gali Kecamatan Muara Bangkahulu termasuk kategori aman dengan rata-rata pH 6,63.

Simpulan : Kualitas air bersih sumur gali warga Kecamatan Muara Bangkahulu termasuk dalam kategori aman sesuai hasil pengamatan dilapangan ditandai dengan nilai rata-rata hasil yang masih dibawah standar baku mutu kesehatan dan layak digunakan.
PEMETAAN KASUS TUBERKULOSIS DI KABUPATEN SAMOSIR TAHUN 2019 – 2020
Authors: Girsang Vierto Irennius , Simbolon Mercy Grace , Damanik Elsarika , Purba Ivan Elisabeth
Published: May 2023

Background :Mycobacterium tuberculosis is a bacterium that causes the infectious disease Tuberculosis (TB). As of 3 february 2020, the number of tuberkulosis cases in Indonesia increased from year to year by 526,977 cases with a CNR of 197 / 100.000 population, where in 2018 there were 511,873 cases with a CNR of 193 / 100.000 popuation. The purpose of this study was to determine the spread of tuberculosis cases in Samosir Regency in 2019 and 2020.
Methods : The research design used is ecology using secondary data. What can be used is aggregate data with data analysis using the help of Quantum GIS software.Results : The distribution of high cases of tuberculosis by sub-district in Samosir Regency in 2019 has three sub-districts while in 2020 there are two sub-districts. The distribution of high cases of tuberculosis based on population density in Samosir Regency in 2019 was in two sub-districts and in 2020 in three sub-districts.
Conclusion : Based on the results of mapping tuberculosis cases in Samosir Regency, it was found that all districts had tuberculosis cases. The distribution of sufferers in the form of red color accumulates in Pangururan District followed by Simanindo District. In terms of population density, the 3 areas with the highest number of red cases are those with a fairly high density, namely Pangururan District, Sitiotio District and Harian District.

Keywords :Tuberculosis, Mapping, Samosir.
Penyuluhan Kesehatan Tentang KB IUD pada Wanita Usia Subur (WUS) di Kelurahan Tanah Merah Lingkungan V Kecamatan Binjai Selatan
Authors: Noviyanti Harahap Rizki , Pabidang Siswanto , Vicky Yulivantina Eka
Published: May 2023

Kualitas generasi dimasa datang ditentukan oleh kualitas keluarganya saat ini. Karena itu, upaya mewujudkan keluarga berkualitas harus dimulai sejak perencanaan keluarga. Alat kontrasepsi intrauterine device (IUD) sangat efektif untuk mencegah kehamilan dibandingkan dengan metode kontrasepsi lainnya seperti suntikan, pil dan implan. IUD dapat mencegah kehamilan sampai 10 tahun dengan tingkat kegagalan yang sangat kecil yaitu sekitar 1%. Kegiatan pengabdian kepada masyarakat tentang Penyuluhan Kesehatan Tentang alat kontrasepsi IUD Pada Wanita Usia Subur (WUS) Di Kelurahan Tanah Merah Lingkungan V Kecamatan Binjai Selatan telah dilaksanakan pada hari selasa, 14 Juni 2022 yang diikuti oleh 53 orang Wanita usia subur. Kegiatan pengabdian kepada masyarakat dilaksanakan dengan beberapa tahapan, yaitu: presentasi materi tentang alat kontrasepsi IUD pada Wanita usia subur, pembagian leaflet, dan diskusi serta tanya jawab dari peserta yang belum paham mengenai alat kontrasepsi jangka panjang. Kegiatan pengabdian ini berhasil memberikan pemahaman kepada ibu khususnya Wanita usia subur tentang mamfaat pemakaian alat kontrasepsi IUD.
Sensitivity studies of nighttime top-of-atmosphere radiances from artificial light sources using a 3-D radiative transfer model for nighttime aerosol retrievals
Authors: Zhang Jianglong , Reid Jeffrey S. , Miller Steven D. , Román Miguel , Wang Zhuosen , Spurr Robert J. D. , Jaker Shawn
Published: May 2023

Abstract. By accounting for surface-based light source emissions and
top-of-atmosphere (TOA) downward lunar fluxes, we adapted the spherical
harmonics discrete ordinate method (SHDOM) 3-dimensional (3-D) radiative
transfer model (RTM) to simulate nighttime 3-D TOA radiances as observed
from the Visible Infrared Imaging Radiometer Suite (VIIRS) Day/Night Band
(DNB) on board the Suomi-NPP satellite platform. Used previously for daytime
3-D applications, these new SHDOM enhancements allow for the study of the
impacts of various observing conditions and aerosol properties on simulated
VIIRS-DNB TOA radiances. Observations over Dakar, Senegal, selected for its
bright city lights and a large range of aerosol optical depth (AOD), were
investigated for potential applications and opportunities for using observed radiances containing VIIRS-DNB “bright pixels” from artificial light sources to conduct aerosol retrievals. We found that using the standard deviation (SD) of such bright pixels provided a more stable quantity for nighttime AOD retrievals than direct retrievals from TOA radiances. Further, both the
mean TOA radiance and SD of TOA radiances over artificial sources are
significantly impacted by satellite viewing angles. Light domes, the
enhanced radiances adjacent to artificial light sources, are strong
functions of aerosol properties and especially aerosol vertical distribution, which may be further utilized for retrieving aerosol layer
height in future studies. Through inter-comparison with both day- and
nighttime Aerosol Robotic Network (AERONET) data, the feasibility of
retrieving nighttime AODs using 3-D RTM SHDOM over artificial light sources
was demonstrated. Our study shows strong potential for using artificial
light sources for nighttime AOD retrievals, while also highlighting larger
uncertainties in quantifying surface light source emissions. This study
underscores the need for surface light emission source characterizations as
a key boundary condition, which is a complex task that requires enhanced
input data and further research. We demonstrate how quality-controlled
nighttime light data from the NASA's Black Marble product suite could serve
as a primary input into estimations of surface light source emissions for
nighttime aerosol retrievals.
The IASI NH3 version 4 product: averaging kernels and improved consistency
Authors: Clarisse Lieven , Franco Bruno , Van Damme Martin , Di Gioacchino Tommaso , Hadji-Lazaro Juliette , Whitburn Simon , Noppen Lara , Hurtmans Daniel , Clerbaux Cathy , Coheur Pierre
Published: May 2023

Abstract. Satellite measurements play an increasingly important role in the study of atmospheric ammonia (NH3). Here, we present version 4 of the Artificial Neural Network for IASI (ANNI) retrieval of NH3. The main change is the introduction of total column averaging kernels (AVKs), which can be used to undo the effect of the vertical profile shape assumption of the retrieval. While the main equations can be matched term for term with analogous ones used in UV/Vis retrievals for other minor absorbers, we derive the formalism from the ground up, as its applicability to thermal infrared measurements is non-trivial. A large number of other smaller changes were introduced in ANNI v4, most of which improve the consistency of the measurements, across time and across the series of IASI instruments. This includes a more robust way of calculating the hyperspectral range index (HRI), explicitly accounting for long-term changes in CO2 in the HRI calculation and the use of a reprocessed cloud product that was specifically developed for climate applications. The NH3 distributions derived with ANNI v4 are very similar to the ones derived with v3, although values are about 15–20 % larger due to the improved setup of the HRI. We exclude further large biases of the same nature, by showing the consistency between ANNI v4 derived NH3 columns with columns obtained with an optimal estimation approach. Finally, with v4, we revised the uncertainty budget and now report systematic uncertainty estimates alongside random uncertainties, allowing realistic mean uncertainties to be estimated.
Impacts and uncertainties of climate-induced changes in watershed inputs on estuarine hypoxia
Authors: Hinson Kyle E. , Friedrichs Marjorie A. M. , Najjar Raymond G. , Herrmann Maria , Bian Zihao , Bhatt Gopal , St-Laurent Pierre , Tian Hanqin , Shenk Gary
Published: May 2023

Abstract. Multiple climate-driven stressors, including warming and increased nutrient
delivery, are exacerbating hypoxia in coastal marine environments. Within
coastal watersheds, environmental managers are particularly interested in
climate impacts on terrestrial processes, which may undermine the efficacy
of management actions designed to reduce eutrophication and consequent
low-oxygen conditions in receiving coastal waters. However, substantial
uncertainty accompanies the application of Earth system model (ESM)
projections to a regional modeling framework when quantifying future changes
to estuarine hypoxia due to climate change. In this study, two downscaling
methods are applied to multiple ESMs and used to force two independent
watershed models for Chesapeake Bay, a large coastal-plain estuary of the
eastern United States. The projected watershed changes are then used to
force a coupled 3-D hydrodynamic–biogeochemical estuarine model to project
climate impacts on hypoxia, with particular emphasis on projection
uncertainties. Results indicate that all three factors (ESM, downscaling
method, and watershed model) are found to contribute substantially to the
uncertainty associated with future hypoxia, with the choice of ESM being the
largest contributor. Overall, in the absence of management actions, there is
a high likelihood that climate change impacts on the watershed will expand
low-oxygen conditions by 2050 relative to a 1990s baseline period; however,
the projected increase in hypoxia is quite small (4 %) because only
climate-induced changes in watershed inputs are considered and not those on
the estuary itself. Results also demonstrate that the attainment of
established nutrient reduction targets will reduce annual hypoxia by about
50 % compared to the 1990s. Given these estimates, it is virtually certain
that fully implemented management actions reducing excess nutrient loadings
will outweigh hypoxia increases driven by climate-induced changes in
terrestrial runoff.
Mediterranean Tropical-Like Cyclones forecasts and analysis usingthe ECMWF Ensemble Forecasting System (IFS) with physical parameterizations perturbations
Authors: Saraceni Miriam , Silvestri Lorenzo , Bechtold Peter , Bongioannini Cerlini Paolina
Published: May 2023

Abstract. Mediterranean Tropical-Like Cyclones, called “medicanes”, present a multiscale nature and their track and intensity have been recognized as highly sensitive to large-scale atmospheric forcing and to diabatic heating as represented by the physical parameterizations in numerical weather prediction. Here, we analyse the structure and investigate the predictability of medicanes with the aid of the European Centre for Medium-Range Weather Forecast (ECMWF) Integrated Forecast System (IFS) ensemble forecasting system with 25 perturbed members at 9 km horizontal resolution (compared to the 16 km operational resolution). The IFS ensemble system includes the representation of initial uncertainties from the ensemble data assimilation (EDA) and a recently developed uncertainty representation of the model physics with perturbed parameters (Stochastically Perturbed Parameterizations, SPP). The focus is on three medicanes, Ianos, Zorbas and Trixie that have been among the strongest in recent years. In particular, we have carried out separate ensemble simulations with initial perturbations, full physics SPP, and with a reduced set of SPP, where only convection is perturbed to highlight the convective nature of medicanes. It is found that compared to the operational analysis and satellite rainfall data, the forecasts reproduce the tropical-like features of these cyclones. Furthermore, the SPP simulations compare to the initial condition perturbation ensemble, in terms of tracking, intensity, precipitation and more generally in terms of ensemble skill and spread. Moreover, the study confirms that similar processes are at play in the development of the investigated three medicanes, in that the predictability of these cyclones is linked not only to the prediction of the precursor events (namely the deep cut-off low) but also to the interaction of the upper-level dynamically driven Potential Vorticity (PV) streamer with the tropospheric PV anomaly that is driven by surface heating and stratiform and convective condensational heating.
iHydroSlide3D v1.0: an advanced hydrological–geotechnical model for hydrological simulation and three-dimensional landslide prediction
Authors: Chen Guoding , Zhang Ke , Wang Sheng , Xia Yi , Chao Lijun
Published: May 2023

Abstract. Forecasting flood–landslide cascading disasters in flood- and landslide-prone regions is an important topic within the scientific
community. Existing hydrological–geotechnical models mainly employ infinite or static 3D stability models, and very few models have incorporated the
3D landslide model into a distributed hydrological model. In this work, we modified a 3D landslide model to account for slope stability under
various soil wetness states and then coupled it with the Coupled Routing and Excess STorage (CREST) distributed hydrology model, forming a new
modeling system called iHydroSlide3D v1.0. Through embedding a soil moisture downscaling method, this model is able to model hydrological and slope-stability submodules even at different resolutions. For a large-scale application, we paralleled the code and elaborated several computational
strategies. The model produces a relatively comprehensive and reliable diagnosis for flood–landslide events, including (i) complete hydrological
components (e.g., soil moisture and streamflow), (ii) a landslide susceptibility assessment (factor of safety and probability of occurrence), and
(iii) a landslide hazard analysis (geometric properties of potential failures). We evaluated the plausibility of the model by testing it in a large
and complex geographical area, the Yuehe River basin, China, where we attempted to reproduce cascading flood–landslide events. The results are well
verified at both hydrological and geotechnical levels. iHydroSlide3D v1.0 is therefore appropriately used as an innovative tool for assessing and
predicting cascading flood–landslide events once the model is well calibrated.
A FULLY AUTOMATIC FOREST PARAMETERS EXTRACTION AT SINGLE-TREE LEVEL: A COMPARISON OF MLS AND TLS APPLICATIONS
Authors: Spadavecchia C. , Belcore E. , Grasso N. , Piras M.
Published: May 2023

Abstract. Forests are vital for ecological, economic, and social reasons, and adopting sustainable forest management practices is necessary. While traditional forest monitoring techniques provide detailed data, they are time-consuming; conversely, geomatic techniques can provide more detailed data for forest resource management. This study aims to assess the suitability of Mobile Mapping Systems (MMS) with simultaneous localisation and mapping (SLAM) technology for precision forestry purposes in challenging environments. We compared the performance of MMS data with Terrestrial Laser Scanning (TLS) data and evaluated the Forest Structural Complexity Tool (FSCT), which was developed for TLS datasets, on MMS data. The case study area is a highly sloped coniferous forest in the Italian Alps affected by a severe fire in 2017. Data were processed using a fully automated open-source Python tool that detects each tree's position, Diameter at Breast Height (DBH), and height. The validation procedure was conducted with respect to the TLS point cloud manually segmented. The results show that using MMS with SLAM technology is suitable for precision forestry purposes in challenging environments and that FSCT performs well on MMS data.