bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of seminal plasma treatment on conception rate in Holstein cows
Authors: Baştan İlktan , Çetin Yunus
Published: June 2024

The seminal plasma (SP) plays significant roles in fertilization processes including capacitation, acrosome reaction, and interaction between sperm and the oocyte. In addition, the SP provides an immunomodulatory effect by the cytokines that it contains, in the female reproductive tract. The aim of this study was to investigate the effect of intrauterine seminal plasma infusion on the success of artificial insemination (AI) in Holstein cows. In the study, a total of 60 multiparous Holstein cows were treated with the Ovsynch protocol (10 μg GnRH on day 0, 500 μg PGF2α on day 7, and 10 μg GnRH on day 9), and artificial insemination was performed 16-18 h after the second GnRH. The cows were categorized into four groups based on the number of AI during lactation period; Group-I (Control AI≤2): inseminated once or twice, Grup- II (SP+AI≤2): inseminated once or twice and infused intrauterine SP, Grup-III (Control AI≥3): inseminated thrice or more, Grup-IV (SP+AI≥3): inseminated thrice or more and infused intrauterine SP. SPs were obtained from 5 Holstein bulls. They were mixed and infused into the corpus uterine immediately before AI. Pregnancy diagnosis by ultrasonography was performed on the 32nd, 60th and 95th days after AI. The conception rates were found 53.3%, 60%, 26.6% and 40%, respectively, between the groups at the 32nd and 60th days after AI (P>0.05). The pregnancy loss was found only in two cows (25%) of Group I, on the day 95th (P>0.05). The days of lactation between the groups were 110±23.2, 104±28.2, 238±53 and 221±46.7, respectively, and were found to statistically significant (P
Molecular Detection of Deformed Wing Virus, Black Queen Cell Virus in Honey Bees in Balıkesir Province
Authors: Karapınar Zeynep , Özüiçli Mehmet
Published: June 2024

Viral infections are among the risk factors affecting the health of honey bees, which are economically and ecologically important insects. These infections cause large-scale colony losses. The primary threat to the well-being of western honey bees (Apis mellifera) is the ectoparasitic mite Varroa destructor, mainly because of its role as a transmitter of viruses. This study aimed to investigate the presence of deformed wing virus (DWV) and black queen cell virus (BQCV) infections, which cause significant colony losses in honey bees, using the reverse transcriptase polymerase chain reaction (RT-PCR) method. For this purpose, adult bees were taken from 50 hives by random sampling in three different regions of Balıkesir. As a result of the analysis of the samples, the genome positivity of DWV and BQCV infections was determined to be 86% (43/50) and 24% (12/50), respectively. In the study’s bee colonies, multiple infections with both viruses were found at a rate of 18% (9/50). The results obtained revealed that Varroa was not effectively controlled in the colonies, especially in the last month of spring, and accordingly, that viral diseases may occur due to Varroa infestation in the winter months.
Acciones constitucionales y mecanismos de participación ciudadana: una mirada desde el caso colombiano
Authors: Restrepo Yepes Juan Diego , Carrillo Benítez Cristian Camilo , Tobón Franco Isabella , Agudelo Taborda Santiago , Montoya Tangarife Sara
Published: June 2024

En el año 1991 surge la Constitución Política de Colombia, una de las constituciones más progresistas y garantistas del momento, un texto de gran impacto del cual es menester llevar a cabo un balance respecto de aquello que ha sido positivo para el país en términos de garantías, así como de lo negativo, y en particular sobre las denominadas acciones constitucionales, mecanismos de participación ciudadana que buscan proteger y respaldarlos derechos de la ciudadanía. Toda vez que la norma de normas se construyó de modo que permitiera su propia materialización en todas las latitudes del territorio, se hace necesario recalcar su invaluable aporte en la construcción de un verdadero marco de protección de los derechos humanos en el que se busque la consolidación de los fines esenciales del Estado social y democrático de derecho. Así, la materialización de la garantía de los derechos ha permitido crear una mayor confianza de la ciudadanía en aspectos básicos como la justicia, sus instituciones, sus herramientas de participación y, específicamente, en la concepción de un escenario real de acceso a la justicia y de participación ciudadana.
An Examination of Faceted Searching in Discovery Systems and the Impact on Information Discovery
Authors: Lai Katie
Published: June 2024

This study compares the performances of the resource type facets and format facets in Primo and WorldCat Discovery respectively. Through looking at librarians’ perceived understanding of selected facets, the information retrieval mechanisms employed, and the search results yielded, the author reveals gaps between users’ perception and the information actually retrieved. The goals are to see how successful Primo and WorldCat Discovery are in making themselves a one-stop shop for music information, and to determine whether the resource type or format facets in these tools facilitate information discovery. The findings also prompt librarians to reflect on what can be done to enhance information discovery through the teaching of information literacy and through collaboration with information and systems providers.
Editorial Column / Chronique de la rédactrices en chef
Authors: Doi Carolyn , Folk-Farber Kyra
Published: June 2024

Editorial Column
Navigating the New Normal
Authors: Deck Trevor , Madill Kevin , McMillan Brian
Published: June 2024

An edited transcript of a roundtable presentation held on Thursday, June 9, 2022, at the Canadian Association of Music Libraries (CAML) 2022 virtual conference. Through a series of six questions chosen to fit in a one-hour format, Music Librarians from three Canadian Universities discussed their experiences with the acquisition of e-score databases. Topics include motivation for acquisition, selection criteria, marketing strategies, patron responses, resource issues, and impact on print collections. This article is offered to a broad audience of library professionals in the belief that topics discussed will be applicable to collection development in subject areas apart from music.
The Secret Path to Reconciliation
Authors: McCallum Duncan
Published: June 2024

In 2016, Canadian musician Gord Downie released a solo concept album titled Secret Path, which dealt with the death of Chanie Wenjack, an Anishinaabe boy who passed away after escaping an Ontario residential school in the 1960s. This album came just one year after the Final Report of the Truth and Reconciliation Commission (TRC) was published, marking a major national step in the reconciliation process. This, in combination with Downie’s terminal brain cancer diagnosis that same year, gave the album a particularly heightened prominence within Canada. This paper examines Downie’s album through the musicological framework of secondary musical witnessing, where Downie acts as a witness in defining the story of Chanie Wenjack. Through analyzing Downie’s role as a musical witness, broader questions of Indigenous allyship are explored through the colonial lens of settler witnessing. This paper aims to explore the nuances and circumstances around Secret Path to understand its historical and cultural significance in the reconciliation movement upon its release, as well as the problems with its legacy related to Indigenous allyship when judged by modern standards as a way of demonstrating how far the reconciliation movement has progressed since 2016.
Designing a Theme-Based Lesson to Develop Creativity Competency for Primary Students
Authors: Hang Ngo Vu Thu
Published: June 2024

Creativity is an important competency that needs to be formed and developed for primary school students. This competency can be educated to students through appropriately designed theme-based lessons. This paper provides some theoretical issues about theme-based lessons and creativity competency, builds a model that shows the characteristics and structure of a theme-based lesson. The paper also shows a process for designing theme-based lessons to help develop creativity competency for primary school students. It provides a possible example of a theme-based lesson designed with the application of the above process that primary school teachers can learn and apply in classroom practices, helping to develop creativity competency for primary students,  contributing to the successful implementation of the General Education Program 2018.
Application EON-XR Virtual Reality Technology in the Design of Biology Learning 10th Grade
Authors: Thi Thuy Quynh Nguyen , Luong Kim Thi
Published: June 2024

With the specific characteristics of Biology subject, it is necessary to have more images illustrating the biological structures that make up the living world, or super-microscopic structures that humans cannot observe with the naked eye such as prokaryotes, eukaryotic cells or microorganisms. Through the outstanding feature of 3D image simulation, EON-XR is an effective support tool in teaching biological structures and processes. Learners can approach Biology knowledge in a more vivid way, easily visualize and have accurate concepts about images, things and phenomena when interacting with them like in the real environment. A 4-steps process was developed when designing a teaching plan that applies virtual reality technology. Some products have been designed using EON-XR virtual reality technology. These products are related to Cell Biology, Biology grade 10th  section such as: biomolecules, structure of cells, prokaryotic and eukaryotic cells. Pedagogical experiments have shown that the application of EON-XR helps students deepen their understanding of knowledge and increase interest in the subject. The information technology capacity of students in the experimental class (classes with VR application) was evaluated and higher than that of students in the control class (taught by traditional methods). The results of this study have proved the effectiveness of designing teaching activities with VR applications to improve the quality of teaching Biology in high schools to meet current educational innovation requirements.
Empowering Goat Farming: Implementing Complete Silage Rations from Local Resources in Talawi Hilie Village
Authors: Lendrawati Lendrawati , Afriani Tinda , Ratni Eli
Published: June 2024

This article presents an innovative approach to addressing the challenges faced by goat farmers in Talawi Hilie Village, Sawahlunto City, West Sumatra Province, Indonesia. The study focuses on implementing complete silage rations utilizing local agricultural and industrial by-products to improve goat nutrition and feed availability. Through community engagement and training, farmers were empowered with knowledge and skills in utilizing readily available feed resources, including rice straw, sugarcane tops, corn straws, coffee husks, and rice bran, for silage production. The training sessions included practical demonstrations of forage processing and silage preparation techniques. Results indicate that implementing complete silage rations effectively addressed the feed scarcity issue and improved the feed quality provided to goats. Farmers demonstrated enthusiasm and willingness to adopt the technology, leading to increased self-sufficiency and welfare improvement in the community. The study underscores the importance of community empowerment and utilization of local resources for sustainable livestock production. Further research is recommended to explore the long-term impact of complete silage rations on goat performance and productivity
GAMELAN BALI DALAM KONSTELASI FILOSOFIS DAN ESTETIK
Authors: Sari Anggy Paramitha
Published: June 2024

Kreativitas secara substantif tidak bisa dipisahkan dari unsur akal dan unsur rasa manusia. Beraneka ragam kesenian dan tradisi yang lahir dari kreativitas manusia akhirnya menjadi ciri khas dari masing-masing wilayah pembuatnya. Gamelan merupakan salah satu dari sekian banyak kekayaan tradisional Indonesia yang lahir dari beragam pertimbangan pikiran, gagasan, ide, rasa dan kreatifitas dari manusia. Gamelan adalah sekelompok alat musik dengan pola ketukan berbeda yang dipergunakan dalam memainkan lagu/gending. Awal mula kemunculan gamelan adalah ketika budaya hindu-budha mulai mendominasi nusantara. Terdapat beberapa jenis gamelan diantaranya gamelan jawa, gamelan sunda, gamelan banjar, gamelan minang dan gamelan bali. Kesemua jenis gamelan tersebut memiliki kekhasan masing-masing sesuai dengan daerah berkembangnya gamelan.Gamelan tidak hanya digunakan sebagai musik pengiring pada kesenian tradisional tetapi juga dipergunakan dalam bebagai ritual keagamaan. Di Bali, hampir semua kegiatan keagamaan khususnya dalam upacara agama hindu selalu mempergunakan iringan gamelan. Gamelan Bali merupakan salah satu unsur panca suara yang selalu ada dalam setiap upacara yajna di Bali. Panca suara ini tidak lepas dari konsep estetika hindu dimana pada setiap suara yang dihasilkan mempunyai makna filosofis. Gamelan Bali yang hadir dalam berbagai ritual hindu di bali bukan saja sebagai hiburan semata tetapi juga memiliki nilai magis yang dapat menggetarkan suasana. Artikel ini akan membahas mengenai filosofi gamelan bali dalam konstelasi estetik.
Medición de la creación de valor a partir del capital intelectual en grandes empresas colombianas
Authors: González González Patricia
Published: June 2024

Profesora titular e investigadora del Departamento de Contabilidad y Finanzas de la Facultad de Ciencias de la Administración de la Universidad del Valle. Cuenta con estudios de Doctorado y Maestría en Contabilidad por la Universidad de São Paulo (Brasil); realizó una pasantía posdoctoral en el Zimmerman Center for International Education and Research in Accounting, Universdad de Illinois en Urbana-Champaign (Illinois, EUA), y es contadora de la Universidad Libre (Cali, Colombia). Su foco de investigación es en el campo de la contabilidad de gestión y entre los temas de investigación se encuentra el del intangible, sobre el que ha escrito diversos libros, artículos y ponencias, como también lo ha hecho en temas relacionados con el costo ABC, TDABC y teoría de las restricciones, entre otros. Ha desempeñado diversos cargos directivos en la Universidad del Valle, y ha realizado actividades como consultora y conferencista en temas relacionados con sus líneas de investigación en el campo de la contabilidad de gestión.
RESPONSABILIDADE EXTRACONTRATUAL DO ESTADO POR OMISSÃO OU FALHA NA PRESTAÇÃO DE SERVIÇOS PÚBLICOS
Authors: Assad e Faria Júnior José Antonio
Published: June 2024

Este artigo examina a natureza jurídica da responsabilidade extracontratual do Estado por omissão na prestação de serviços públicos. Através de uma análise doutrinária, discute-se como o tema é tratado, destacando a aplicação das teorias de responsabilidade objetiva e subjetiva. O artigo explora a relevância da distinção entre atos comissivos e omissivos e suas implicações para o direito administrativo brasileiro. A pesquisa contribui para o entendimento de como a responsabilidade estatal é estabelecida em casos de danos causados por falhas ou ausência na prestação de serviços, oferecendo uma perspectiva crítica.
Code-switching in Kurdish communication "Khanaqin Dialect as an Example "
Authors: Rashid Salam Raheem , Hama Ameen Khoshnaw Azeez , Muhamed Sozan Kareem
Published: June 2024

In linguistics, especially in communication, code-switching, or skipping from one linguistic code (dialect or a language) to another, as a reference to the use of several languages or several dialects together, usually occurs in multilingualism groups that the speaker uses the elements of multiple diverse languages. This process is related to a number of factors, principles and specific circumstances. Khanaqin City is one of these areas where this phenomenon is witnessed and worth studying, this by taking its geographical location and political situation into consideration, and their influences on this linguistics phenomenon.
      Consequently, this study which is entitled Code-switching in Kurdish communication "Khanaqin Dialect as an Example‌‌", is devoted and intended to demonstrate that in linguistic sphere, it is possible to deal with the phenomenon through speech analysis. i.e., it is attempted that the code-switched linguistic forms of this area to be discussed and studied depending on linguistics criteria.
      In order to achieve the objectives, descriptive analysis method has been applied in this paper. The structure of the paper in spite of the preface and an introduction of the subject is outlined into two parts as follows:
      The first part is the theoretical aspect of the research, in a brief introduction of Khanaqin and the use of language there have been presented. The second part is the practical aspect of the study, which adresses the phenomenon of code switching, its principles and types within the scope of the research. It has been strived to elaborate the topics in the form of analysis and providing examples.
      The results obtained, the list of bibliography, in addition to this summary in Arabic and English languages conclude this effort.
Moral aspects of despair: Kamran Mukri's Ethical Analysis of the Text (For Awareness)
Authors: Ahmed Dilman Qadir
Published: June 2024

This paper examines Kamran Mukri's poem “For Awareness” within the framework of Kurdish literary criticism and highlights the moral aspects of despair in the text. It investigates the motivation behind the poem and its intentions. The study points to the role and importance of poetry as a tool in raising awareness about the suffering of the poor and oppressed. It analyzes the historical context, explores the relationship between women, country, and nature, and emphasizes the poet's inner struggle. The study uses a descriptive-analytical method and makes use of an ethical approach to understanding despair. The aim is to contribute to the Kurdish critical discourse on Kamran Mukri's poetry.
An Eco-Traumatic Iraqi Experience in Sinan Antoon's The Corpse Washer: An Eco-Critical Perspective
Authors: Jassim Shaima Abdullah , Mohammed Sarmad Majeed
Published: June 2024

From the ancient time up to now, the concept of place and its shadow in literary milieu are not passive. This mutual interconnectedness between literature and place considers a complex relationship that weaves many notions within its context. 
     However, in this present paper, the researchers focus on one of the most well-known Iraqi novel which is The Corpse Washer (2013), written by Sinan Antoon (1967-present). Through this novel, the researchers negotiate the traumatic experience of Iraqi people that stems from the trauma of place and its impact on the relationship between human being and environment where they live. By adapting Eco-trauma theory, which is set by Tina Amorok, the researchers conclude that the novelist creates a microcosm to examine the nature of relationship between human being and environment. Based on this fact, they find that Antoon has portrayed the relationship between environment and Iraqi individuals as unsettled relationship due to the traumatic experience that place causes upon Iraqi people. Thus, Antoon's symbolic depiction of the protagonist as a rebellious character comes from the influence of environment upon human beings which formulates their attitudes and understanding. This is clearly depicted by the protagonist Jawed, who always tries to break his relationship with the environment for the sake of achieving his dreams and be an independent man.
The Spoken Hebrew Language A Linguistic Study According to Selected Phonological and Morphological Aspects
Authors: Sabah Shamki Saad Abd Al-Sada
Published: June 2024

In Hebrew culture, there is a tendency to view spoken language with suspicion. There are those who diagnose "slang" as the speech of those who are uneducated. This relationship expresses a polar approach to language, a tendency to divide it into two parts. The standard (super level) written language is the legitimate unit and the language of speach they strive to correct. A large part of slang predominates in colloquial Hebrew speech, uttered with good will, being constructed from the spontaneity of conversation, without planning or editing. While another part gets created consciously and deliberately, for the sake of pleasure that expresses the human nature of renewal, recovery and rebellion. We also find that the normative approach has dominated the Hebrew culture, which dealt with written sources as the only legitimate language, while ignoring the spoken language. This conservative approach is the reason for not studying the spoken language for many years, which means that there will be no documentation and recording of this language in the early years of the establishment of the Zionist entity in Palestine. The development of language is considered one of the greatest achievements of the Zionist movement. In the early years of the Hebrew language revival, the Hebrew language revivers did not differentiate between written and spoken language, and believed that deviations in speech would be corrected when they were able to master the language just as misspellings. Today, the spoken language has priority in Hebrew linguistic research, because of its historical precedence, and there is a clear distinction between languages that stems from the different nature of each medium.
Verb tenses in passive sentences
Authors: Ahmed Treefa Mohsen , Raswl Abdulla Hussen
Published: June 2024

This research demonstrates the tenses and aspects in passive voice in the Kurdish language. The research shows how the patterns and principles of the tenses and aspects and their structures help to distinguish between the passive voice sentences. The research consists of two sections: The first section defines passive voice, describes the peculiarities of passive voice and sheds light on the reasons for passive voice. The second section deals with the tenses differently in terms of their patterns, their order and structure of roots of verb, time morphemes, indicators of passive voice, occurring pronounces peculiar to subject and object, and the time morphemes peculiar to passive voice. The research attempts to illustrate all the structures and each one is explained in a particular table. Also, all the tenses and aspects in passive voice and classified for further clarity. The research concludes with some findings.
Research on the multi-scenario control strategy of an active distribution network based on Rotary Power Flow controller
Authors: Mingming Shi , Jun Ma , Xiaolong Xiao , Fan Wu
Published: June 2024

Aiming at the problems of complex power distribution and difficult adjustment in the active power distribution network, a low-cost, harmonic-free, and low-loss electromagnetic Rotating Power Flow Controller (RPFC) scheme is proposed. First, the topology, working principle, and equivalent circuit of RPFC are introduced, the steady-state characteristics of RPFC are studied, and a steady-state voltage source model containing RPFC lines is established. On this basis, in order to solve problems such as voltage over the limit, phase angle difference, line flexible closed-loop closing, and power control in the active distribution network, an RPFC rotor angle solution strategy based on the improved Multi-Scenario Adaptive Genetic Algorithm (MAGA) was proposed. Taking the actual network as a case, a specific algorithm model was established based on Matlab/Simulink, and compared with the RPFC system under traditional PI control. The results show that using MAGA as the control algorithm enables RPFC to have better performance in voltage regulation and power flow control scenarios. In the voltage regulation scenario, MAGA-RPFC saves 1.5 s of regulation time compared with traditional PI-RPFC. In the power control scenario, the adjustment time is saved by 18.2 s. At the same time, the simulation results show that RPFC can effectively solve the voltage regulation, flexible closed-loop, and power regulation problems in active distribution networks, and has broad application prospects.
Metallosis After Total Hip Arthroplasty
Authors: Flatt Sarah , Rawat Mohini
Published: June 2024

A 67-year-old overweight woman was referred to physical therapy by an orthopaedic surgeon for lumbosacral spondylosis without myelopathy. Past medical history included a right total hip arthroplasty (THA) 9 years ago and a left THA 7 years ago. The patient underwent a 6-week physical therapy program but did not improve as expected, which resulted in a consultation with another in-house physical therapist who performed musculoskeletal ultrasound of the right hip, revealing a soft tissue mass. The patient was referred back to the orthopaedist, who ordered magnetic resonance imaging that confirmed an oval mass along the lateral right hip. Further testing was positive for cobalt poisoning, and the patient was diagnosed with metallosis.

JOSPT Cases 2021;1(3):197–198. doi:10.2519/josptcases.2021.10339
Features of psoriasis treatment with infection COVID-19
Authors: Tashkenbaeva Umida A. , Aliev Aziz Sh. , Usmanaliev Sanjar A.
Published: June 2024

Background. Today, one of the difficult tasks in modern dermatology is the management of patients with chronic dermatoses, including psoriasis, due to a new coronavirus infection. The general condition of the patients, as well as concomitant therapy for the underlying disease, may subsequently produce severe side effects and complicate the treatment of concomitant skin pathology in patients in this category.
Aim. The purpose of our study was to optimize the treatment of patients with psoriasis against the background of COVID-19 infection.
Methods. Our study included 34 patients with psoriasis who were hospitalized at the Zangiota Clinical Hospital, specializing in patients with COVID-19 infection from 2020 to 2022. Also, all patients were divided according to the severity of the underlying disease according to the “Temporary recommendations for the management of patients infected with COVID-19”, fifth version of 2020. The severity of the psoriatic process was assessed using the PASI index.
Results. If patients have a psoriatic process, it is more rational to use biological drugs for the treatment of COVID-19 infection due to the absence of exacerbation of the psoriatic process in dynamics.
Conclusion. Treatment of patients with COVID-19 infection with casivirimab + imdevimab showed a positive effect on the dynamics of skin elements and the absence of relapses during three months of observation. While standard therapy for coronavirus infection gives a good regression of skin elements on the 10th day of therapy, after a month there is a progression of the skin process, the appearance of itching and new elements of psoriasis.
Manometric profile of patients presented with dysphagia – A hospital-based descriptive study
Authors: Yogisparan Pavitra Vyshnavi , Arun P. , Vijayabaskaran S. , Sairam Vidhya , Deepalakshmi K. , Mukundan S. , Thirumal P. , Vasanthi R. , Venkatakrishnan L.
Published: June 2024

Objectives:

The prevalence of dysphagia is 16–22%. Achalasia is characterised by impaired relaxation of the lower oesophageal sphincter (LES) and absent oesophageal peristalsis. Minimally invasive procedures, endoscopic pneumatic balloon dilatation (PD) and peroral endoscopic myotomy (POEM) are treatments of choice. We aimed to assess the manometric profile of patients presented with dysphagia and pre- and post-LES pressure and integrated relaxation pressure (IRP) of patients who underwent PD and POEM.

Materials and Methods:

One hundred and twenty-nine patients presented with dysphagia underwent high resolution oesophageal manometry (HREM). Manometric parameters: IRP, LES and pattern of motility were noted. According to Chicago classification 4.0, those who are diagnosed with achalasia underwent PD (17) and POEM (15). Statistical analysis was performed using the Statistical Package for the Social Sciences version 28. Pre- and post-procedure values (IRP and basal LES) were compared using the Wilcoxon signed-rank test.

Results:

Out of 129 patients with dysphagia, 57 had increased IRP and 75 had simultaneous motility. The mean LES pressure and IRP were found to be 28 ± 19.82 and 17 ± 14.04 mmHg, respectively. On analysis, of patients who underwent procedures PD (17) and POEM (15), a statistically significant decrease in IRP was observed in patients with post POEM compared to post PD status (P = 0.005 and 0.017, respectively). Reduced basal LES pressure was observed in patients with post-POEM status compared to post-PD status, which was not statistically significant.

Conclusion:

About 44% of patients presented with dysphagia were diagnosed with achalasia cardia. POEM procedure was found to be more effective compared to pneumatic dilatation.
Sepsis Episodes Caused by Pressure Injuries in Critical Illness: A Retrospective Observational Cohort Study
Authors: Kaya Pınar , Kaya Murad , Girgin Nermin , Kahveci Ferda , Akalın Emin , İşçimen Remzi
Published: June 2024

BACKGROUND: Critically-ill patients (CIPs) with pressure injuries (PIs) may develop bloodstream infections (BSIs). PURPOSE: To identify predisposing factors and discuss diagnosis and management of sepsis-related PIs in CIPs. METHODS: The records of CIPs in the intensive care unit (ICU) between January 1, 2014, and January 1, 2020, with PI with sepsis-diagnoses and with different site cultures that were positive concurrent with bloodstream-cultures were retrospectively reviewed. RESULTS: Ninety-one sepsis episodes were included in the study. Low albumin level (U = 382.00, P = .006), renal failure (odds ratio [OR], 0.108 [95% CI, 0.015-0.783]; P = .025), and length of ICU stay (U = 130.00, P < .001) were identified as risk factors of BSIs due to PIs. The probability of BSI during a sepsis episode was lower in CIPs with PIs with higher C-reactive protein levels (U = 233.00, P < .001) and whose injury resulted from trauma or surgery (OR, 0.101 [95% CI, 0.016-0.626]; P = .014). The mortality was higher in CIPs with PI-induced BSIs (OR, 0.051 [95% CI, 0.008-0.309]; P = .001). CONCLUSIONS: Pressure injury-induced sepsis was associated with a high risk of 28-day mortality. The findings suggest that CIPs with PI are at increased risk of BSIs if they have low albumin levels, renal-failure, and prolonged ICU stay during sepsis episodes.
actions des élèves avec un didacticiel
Authors: Athias Francine
Published: June 2024

Les environnements numériques sont investis par les professeurs, en particulier dans des tâches de réinvestissement. C’est précisément le cas du didacticiel en mathématiques que nous interrogeons, calcul@tice. L’usage de ces environnements numériques et de leurs supports (ordinateurs portables ou tablettes) se développe du fait de leur mobilité, de leurs applications engageantes, tant du point de vue des élèves que des professeurs. La plupart du temps, les élèves sont seuls, développant ainsi des niveaux de mise en fonctionnement des connaissances. Ce qu’ils font à ces moments reste caché des professeurs. Nous rendons compte de ces niveaux et de la mobilisation de savoirs déjà connus dans ce contexte. En appui sur ces résultats, nous sommes amenés à densifier les situations.
PENGARUH PENGGUNAAN ASAM ORGANIK UNTUK MENURUNKAN KADAR LOGAM TIMBAL (Pb) PADA DAGING SIPUT GONGGONG (THE EFFECT OF THE USE OF ORGANIC ACIDS TO REDUCE THE LEVELS OF METAL LEAD (Pb) ON THE MEAT OF GONGGONG SNAILS)
Authors: Amelia Fitrah , Ramses Ramses , Ismarti Ismarti
Published: June 2024

Pollution that often occurs at sea is heavy metal pollution. Heavy metals that often pollute are Lead metals (Pb). Heavy metal pollution that occurs often has an impact on plants and animals that live in the sea. Animals that are often contaminated with heavy metals are snails because of the nature of snails that can accumulate metals due to their persistent nature, filter feeders, slow movements to avoid metal pollution. The purpose of this study is to reduce metal pollution in seafood, one of the ways that can be done by soaking seafood using organic acids such as tamarind and lime, because organic acids contain citric compounds that can bind to metals. This type of research is an experimental research design with Randomized Pretest-posttest control group design. The experimental design used was a Completely Randomized Design (CRD). Metal content analysis was carried out using the Perkin Elmer Type PinAAcle 900T brand AAS. The results were obtained that tamarind can decrease Pb metal levels in the bark snail meat at optimum conditions at a concentration of 10%, immersion time of 60 minutes and a percentage reduction of 47.1%. While the optimum condition of lime occurs at 10% concentration and soaking time is 30 minutes with a 25% percent decrease. So it can be said that tamarind is better in reducing metal content compared to Lime
Natural rights on the book “Silent Springer” Critical Review of Ecological Citizenship
Authors: Dewantara Jagad Aditya
Published: June 2024

Rachel Carson's book "Silent Spring" is often credited with kicking off the modern environmental protection movement. In the book, Carson details the destructive effects that synthetic pesticides, particularly D.D.T., can have on ecosystems and human health. This book, first released in September of 1962, coincidentally served as a gathering place for those involved in the environmental movement. Carson argues in his book that pesticides such as D.D.T. eliminate bugs and wreck the food chain and the natural environment. It poses a risk to the populations of birds and fish and might make youngsters more susceptible to illness (Carson, 2002).Carson further said that public authorities blindly accepted the marketing promises made by the chemical business without giving the claims proper attention. He accused the chemical industry of disseminating deception. Carson started working on environmental conservation concerns in the late 1950s, focusing primarily on problems relating to synthetic pesticides. His study led to the production of the film "Silent Spring," which raised people's awareness of environmental issues in American culture. The book was met with considerable criticism from chemical firms. However, it managed to influence public opinion, which led to a reversal in pesticide policy in the United States, including a nationwide ban on the use of D.D.T. for agricultural purposes. It ultimately led to the formation of the Environmental Protection Agency (EPA). Because of Carson's work, there has been a substantial shift in how individuals and governments think about the environment and humans' role in destroying it. The book also ignited a discussion about the regulation of the use of pesticides and responsibility for nature. As a result, it became one of the most essential works in the history of environmental conservation movements and motivated efforts to conserve wildlife and maintain the balance of ecosystems. In addition, the book became one of the most influential works in the history of environmental conservation movements.
The Role of The Community In Creating A Village Conscious Of Religious Harmony In Tulungrejo Village, Bumiaji District, Batu City
Authors: Yusuf Nurbani , Wibowo Arif Prasetyo , Zuriah Nurul , Sovia Sasmita Nazathusohiroh
Published: June 2024

The objectives of this study are (1) analyzing and describing the role of the community, (2) analyzing and describing the obstacles faced by the community, (3) analyzing and describing solutions to face obstacles in realizing a Religious Harmony Awareness Village in Tulungrejo Village, Bumiaji District, Batu City. This research uses a descriptive qualitative approach with a case study research design. This research was conducted in Tulungrejo Village, Bumiaji District, Batu City. Data collection in this study used structured interview techniques, passive participant observation of core informants and documentation with data sources obtained based on primary and secondary data. The data in this study is in the form of administrative data and local community activities. Data analysis in this study uses modified data analysis and interactive models by checking the validity of findings through credibility, transferability, dependability, and confirmability tests. To obtain reliable data, validation is carried out with source triangulation techniques. The result of this research is the contribution of the local community through mutual assistance and participation in community activities, especially in inter-religious activities. The obstacles in realizing the Religious Harmony Awareness Village are the fanaticism of the community in small groups who are less tolerant of differences between religious communities. The solution to overcome these obstacles is through the application of mutual openness and respect for each other.
Graph Neural Networks for Identifying Protein-Reactive Compounds
Authors: Cano Gil Victor Hugo , Rowley Christopher
Published: June 2024

The identification of protein-reactive electrophilic compounds is critical to the design of new covalent modifier drugs, screening for toxic compounds, and the exclusion of reactive compounds from high throughput screening. In this work, we employ traditional and graph machine learning (ML) algorithms to classify molecules being reactive towards proteins or nonreactive. For training data, we built a new dataset, ProteinReactiveDB, composed primarily of covalent and noncovalent inhibitors from the DrugBank, BindingDB, and CovalentInDB databases. To assess the transferability of the trained models, we created a custom set of covalent and noncovalent inhibitors, which was constructed from the recent literature. Baseline models were developed using Morgan fingerprints as training inputs, but they performed poorly when applied to compounds outside the training set. We then trained various Graph Neural Networks (GNNs), with the best GNN model achieving an Area Under the Receiver Operator Characteristic (AUROC) curve of 0.80, precision of 0.89, and recall of 0.72. We also explore the interpretability of these GNNs using Gradient Activation Mapping (GradCAM), which shows regions of the molecules GNNs deem most relevant when making a prediction. These maps indicated that our trained models can identify electrophilic functional groups in a molecule and classify molecules as protein-reactive based on their presence. We demonstrate the use of these models by comparing their performance against common chemical filters, identifying covalent modifiers in the ChEMBL database and generating a putative covalent inhibitor based on an established noncovalent inhibitor.
Boosting Chemiexcitation of Phenoxy-1,2-Dioxetanes through 7-Norbornyl and Homocubanyl Spirofusion
Authors: Gutkin Sara , Shelef Omri , Babjaková Zuzana , Tomanová Laura Anna , Babjak Matej , Spitz Urs , Zhou Qingyang , Ma Pengchen , Houk Kendall N. , Shabat Doron
Published: June 2024

The chemiluminescent light-emission pathway of phenoxy-1,2-dioxetane luminophores is increasingly attracting the scientific community's attention. Dioxetane probes that undergo rapid, flash-type chemiexcitation demonstrate higher detection sensitivity than those with a slower, glow-type chemiexcitation rate. This is primarily because the rapid flash-type produces a greater number of photons within a given time. Herein, we discovered that dioxetanes fused to 7-norbornyl and homocubanyl units, present accelerated chemiexcitation rates supported by DFT computational simulations. Specifically, the 7-norbornyl and homocubanyl spirofused dioxetanes exhibited a chemiexcitation rate of 14.2-fold and 230-fold faster than the spiro-adamantyl-dioxetane, respectively. A turn-ON dioxetane probe for the detection of the enzyme β-galactosidase, containing the 7-norbornyl spirofused unit, exhibited an S/N value of 415 with low enzyme concentration. This probe demonstrated an increase in detection sensitivity towards β-galactosidase with a limit-of-detection value that is 9-fold more sensitive than that obtained by the adamantyl counterpart. Interestingly, the computed activation free energies of the homocubanyl and 7-norbornyl units were correlated with their CCsC spiro-angle, to corroborate the measured chemiexcitation rates.
Metal- versus Ligand-Centered Reactivity of a Cobalt-Phenylenediamide Complex with Electrophiles
Authors: Zou Minzhu , Kuruppu Sewwandi , Emge Thomas , Waldie Kate
Published: June 2024

A new series of [CoIII–CF3]n+ complexes supported by a bidentate redox-active ligand with is presented. The cationic [Co–CF3]+ complex was first obtained by reacting [CpCo(tBuUreaopda)] (Cp = cyclopentadienyl, opda = o-phenylenediamide) with an electrophilic trifluoromethyl source, for which the redox-active phenylenediamide ligand serves as a 2e– reservoir to generate [CpCp(tBuUreabqdi)(CF3)]+ (bqdi = benzoquinonediimine). Electrochemical studies of [Co–CF3]+ revealed two reversible 1e– reductions. Chemical reduction with 1 or 2 equiv. reducing agent enabled isolation of the neutral and anionic complexes, respectively, where the [CoIII–CF3] bond remains intact in all three oxidation states (n = +1, 0, −1). Structural analysis shows systematic changes to the redox-active ligand backbone upon reduction, consistent with sequential ligand-centered electron transfer in the series [bqdi]0 to [s-bqdi]•– to [opda]2–. In contrast, the reaction of [CpCo(tBuUreaopda)] with alkyl triflates resulted in ligand-centered alkylation at the ureayl groups instead of the targeted Co–alkyl bond formation, suggesting less favorable bond formation at cobalt and greater nucleophilic accessibility of the ligand compared to the metal center.
Bartender: Martini 3 Bonded Terms via Quantum Mechanics-based Molecular Dynamics
Authors: Pereira Gilberto P. , Alessandri Riccardo , Domínguez Moisés , Araya-Osorio Rocío , Grünewald Linus , Borges-Araújo Luís , Wu Sangwook , Marrink Siewert J. , Telles de Souza Paulo Cesar , Mera-Adasme Raul
Published: June 2024

Coarse-grained (CG) molecular dynamics (MD) simulations have grown in applicability over the years. The recently released version of the Martini CG force field (Martini 3) has been successfully applied to simulate many processes, including protein-ligand binding. However, the current ligand parameterization scheme is manual and requires an a priori reference all-atom (AA) simulation for benchmarking. For systems with suboptimal AA parameters, which are often unknown, this translates into a CG model which does not reproduce the true dynamical behavior of the underlying molecule. Here we present Bartender, a quantum mechanics (QM)/MD-based parameterization tool written in Go. Bartender harnesses the power of QM simulations and produces reasonable bonded terms for Martini 3 CG models of small molecules in an efficient and user-friendly manner. For small, ring-like molecules, Bartender generates models whose properties are indistinguishable from the human-made models. For more complex, drug-like ligands, it is able to fit functional forms beyond simple harmonic dihedrals, and thus better captures their dynamical behavior. Bartender has the power to both increase the efficiency and the accuracy of Martini 3-based high-throughput applications by producing stable and physically realistic CG models.
Deep Learning-Driven Prediction of Chemical Addition Patterns for Carboncones and Fullerenes
Authors: Li Zhengda , Chen Xuyang , Wang Yang
Published: June 2024

Carboncones and fullerenes are exemplary π-conjugated carbon nanomaterials with unsaturated, positively curved surfaces, enabling the attachment of atoms or functional groups to enhance their physicochemical properties. However, predicting and understanding the addition patterns in functionalized carboncones and fullerenes are extremely challenging due to the formidable complexity of the regioselectivity exhibited in the adducts. Existing predictive models fall short in systems where the carbon molecular framework undergoes severe distortion upon high degrees of addition. Here, we propose an incremental deep learning approach to predict regioselectivity in the hydrogenation of carboncones and chlorination of fullerenes. Utilizing exclusively graph-based features, our deep neural network (DNN) models rely solely on atomic connectivity, without requiring 3D molecular coordinates as input or iterative optimization of them. This advantage inherently avoids the risk of obtaining chemically unreasonable optimized structures, enabling the handling of highly distorted adducts. The DNN models allow us to study regioselectivity in hydrogenated carboncones of C70H20 and C62H16, accommodating up to at least, 40 and 30 additional H atoms, respectively. Our approach also correctly predicts experimental addition patterns in C50Cl10 and C76Cln (n = 18, 24, and 28), whereas in the latter cases all other known methods have proven unsuccessful. Compared to our previously developed topology-based models, the DNN’s superior predictive power and generalization ability make it a promising tool for investigating complex addition patterns in similar chemical systems.
Digichem: Computational Chemistry For Everyone
Authors: Lee Oliver , Gather Malte , Zysman-Colman Eli
Published: June 2024

We describe a new tool for the efficient management of computational chemistry. Digichem is a program that automates and simplifies nearly the entire computational pipeline, including large-scale batch submission of calculations, analysis and results parsing, the generation of 3D density plots and 2D graphs of calculation data, storage and retrieval of calculation results to a database, and automated handling of multi-step jobs. The program is designed to reduce the tedium and likelihood of human error for researchers of all skill-levels but is particularly targeted towards novice users who otherwise may find the barrier to entry to computational chemistry unnecessarily high. To date, this program has been used to successfully run and analyse over 50,000 individual calculations, evidencing its usefulness and utility. The Digichem program is presently released under a free-to-use license, and components of the Digichem system are additionally available under an open-source license.
Machine-Learning Screening of Inorganic Compounds for Defect Spin Properties
Authors: Isse Abdullahi
Published: June 2024

An ensemble regression algorithm predicting refractive index, band gap and magnetic susceptibility utilizing elemental composition based physical descriptors is developed to screen for inorganic compounds with color defect spin properties at low computational cost. Mean absolute error (MAE) values of 0.46 for refractive index, 0.65 eV for bandgap utilizing gradient boost regression and 2.95e-3 cm3/mol for magnetic susceptibility with random forest regression were obtained via 70:30 train-test splits. When screened for threshold values of bandgap >2 eV, refractive index > 2 and magnetic susceptibility < 10e-5 cm3/mol, notable binary compounds with defect spin properties include GaN and SiC among 348 compounds demonstrating model utility.