bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Roller Pump Pulse in the Arterial Needle Area during Hemodialysis
Authors: Kasparek Milos , Novakova Ludmila , Malik Jan
Published: November 2021

Vascular access is a lifeline for hemodialysis patients. Its lifetime is affected by many hemodynamic factors such as pressure, flow regime and wall shear stress. During hemodialysis, changes in hemodynamic parameters occur due to the flow from needles inserted into the vascular system. Primarily, there is a change in shear stress that affects the vascular wall. Pathological effects of high or low WSS are known. The effect of jet from a venous needle on hemodynamics parameters was studied, but the influence of the arterial needle on hemodynamics parameters is not sufficiently studied. To understand its possible effects, we performed in vivo and in vitro studies. Methods. In vivo experiment: The existence of flow reversal around the suction needle was visualized in a group of 12 randomly selected patients using ultrasound velocity profiling (Doppler ultrasonography) during hemodialysis. In vitro experiment: The flow field was measured using the stereo particle image velocimetry method (stereo PIV). Two regimes were studied. In the first regime, the fluid in the extracorporeal circuit was pumped by a peristaltic pump. In the second regime, the continuous pump was used in the extracorporeal circuit. The conditions were set to resemble those in vascular access during a hemodialysis session. Flow volume was set to 600 mL/min for vascular access and 200 mL/min for the extracorporeal circuit. Results. The main finding of this study was that the wall in the region of the arterial needle was stressed by backflow through the arterial needle. Since this was a variable, low-shear stress loading, it was one of the risk factors for the development of stenosis. Cyclic flow reversal was apparent in all of the included hemodialysis patients. The stereo PIV in vitro experiment revealed the oscillating character of wall shear stress (WSS) inside the model. High shear stress was documented upstream of the injection point of the arterial needle. An area of very low WSS was detected right behind the injection point during a pulse of the peristaltic pump. The minimal and maximal values of the WSS during a pulse of the peristaltic pump in the observed area were −0.7 Pa and 6 Pa, respectively. The distribution of wall shear stress with the continual pump used in the extracorporeal circuit was similar to the distribution during a pulse of the peristaltic one. However, the WSS values were continual; the WSS did not oscillate. WSS ranged between 4.8 Pa and 1.0 Pa.
Is Primary HPV with Secondary p16/Ki67 Dual-Stain an Alternative HSIL-Risk Detection Strategy in Cervical Cancer Screening for Women under 30 Years?
Authors: Trzeszcz Martyna , Mazurec Maciej , Jach Robert , Mazurec Karolina , Jach Zofia , Kotkowska-Szeps Izabela , Kania Magdalena , Wantuchowicz Mariola , Prokopyk Anna , Barcikowski Piotr , Przybylski Marcin , Wach Joanna , Halon Agnieszka
Published: November 2021

Recently, cervical cancer rates elevation has been noted in women aged 20–39 years in regions with a very high human development index (HDI). The onset of cancer elevation rates is observed in the age range of 25–29 years, which should necessitate effective precancer screening in younger age groups, including those <25 years. From 30.066 liquid-based screening tests results (n = 30.066), 3849 liquid-based cytology, 1321 high-risk human papillomavirus (HRHPV) and 316 p16/Ki67 performed in women <30 years were selected. Performance characteristics were calculated for three screening models: primary HRHPV with p16/Ki67 triage, primary cytology with reflex HPV and primary cytology alone. Primary HRHPV with p16/Ki67 triage was significantly more sensitive in high-grade squamous intraepithelial lesion quantified with cervical intraepithelial neoplasia grade 2 or worse [HSIL(CIN2+)] detection than cytology with reflex HRHPV and cytology alone (83.3% vs. 70.8%/45.8%) and had significantly higher diagnostic predictive values (PPV:29.4%/21.3%/22.9%; NPV:91.7%/82.9%/82.2%, respectively at CIN2+ threshold). The number of colposcopies per HSIL(CIN2+) detection indices was 3.4, 4.7 and 4.4, respectively. Primary HPV testing in women <30 years with p16/Ki67 triage of HPV-positive cases might be an effective cervical cancer screening strategy for HSIL(CIN2+) detection with superior diagnostic performance when compared with primary cytology-based models. Women <25 years might also benefit from an introduction to a more sensitive screening approach.
Analysis of Compliance with Time under Tension and Force during Strengthening Exercises with Elastic Bands
Authors: González-Rosalén Javier , Medina-Mirapeix Francesc , Cuerda-Del Pino Alba , Moreno-Segura Noemi , Gacto-Sánchez Mariano , Martín-San Agustín Rodrigo
Published: November 2021

Quantifying training variables of a physical exercise modality is essential for an appropriate dosage. In training with elastic bands, time under tension (TUT) and force represent the duration and intensity of this force-training modality. The aims of this study were to evaluate the degree of compliance to TUT prescription for three different scenarios of two exercises and the comparison of the force values obtained versus the estimate values. A total of 29 healthy volunteers were evaluated in a clinical environment under controlled conditions in 3 different scenarios (different velocities or ROMs) of both shoulder abduction and knee extension in 2 sets of 10 repetitions per scenario within a single session. Concentric and isometric phases showed a higher degree of compliance for their TUTs than the eccentric phase TUTs for all scenarios of both exercises, whereas the degree of compliance was higher for the total TUT than for the phases’ TUTs. Additionally, the eccentric phase showed a general tendency to develop for longer time periods than prescribed, whilst the fast scenario showed a higher degree of compliance for isometric phase TUTs and total TUTs than the extant two scenarios in both exercises. On the other hand, the force of the elastic bands tends to be overestimated according to the estimates of the manufacturers. These findings, both those related to the degree of compliance with TUTs and the force analysis, can be used by physiotherapists and other exercise professionals as a reference to achieve a good dosage of routine exercises with elastic bands.
Role of Endoscopic Ultrasound in Liver Disease: Where Do We Stand?
Authors: Pavic Tajana , Mikolasevic Ivana , Kralj Dominik , Blazevic Nina , Skrtic Anita , Budimir Ivan , Lerotic Ivan , Hrabar Davor
Published: November 2021

As the burden of liver disease in the general populace steadily increases, so does the need for both advanced diagnostic and treatment options. Endoscopic ultrasound is a reliable diagnostic and therapeutic method that has an established role, foremost in pancreatobiliary pathology. This paper aims to summarize the growing role of endoscopic ultrasound in hepatology based on the search of the current literature. A number of applications of endoscopic ultrasound are reviewed, including both noninvasive methods and tissue acquisition in focal and diffuse liver disease, portal hypertension measurement, detection and management of gastric and esophageal varices, treatment of focal liver lesions and staging of pancreatobiliary malignancies, treatment of cystic and solid liver lesions, as well as liver abscess drainage. Both hepatologists and endoscopists should be aware of the evolving role of endoscopic ultrasound in liver disease. The inherent invasive nature of endoscopic examination limits its use to a targeted population identified using noninvasive methods. Endoscopic ultrasound is one the most versatile methods in gastroenterology, allowing immediate access with detection, sampling, and treatment of digestive tract pathology. Further expansion of its use in hepatology is immanent.
AUditive Direct in Utero Observation (AUDIO): A Randomized Controlled Trial for a Prenatal Demonstration of Fetal Hearing
Authors: Larcher Laura , Farina Antonio , Morano Danila , Rimondi Nadia , Leccese Vincenza , Contro Elena
Published: November 2021

Introduction: The objective of this randomized controlled study was to demonstrate whether acoustic stimulation in utero is associated with fetal reactivity which is documentable by cardiotocography. Materials and methods: A monocentric randomized controlled trial was performed at a single university tertiary hospital between September 2016 and July 2017. This study was registered as a randomized clinical trial on clinicaltrail.gov (registration number NCT04622059). Unselected pregnancies at term of gestation were consecutively recruited for the purpose of this study. After 10 min of normal cardiotocography without accelerations (non-stress-test with a basal frequency between 110 and 150 beats/min, normal variability between 6 and 15 b/min, no accelerations, and no fetal movements), fetuses were randomized at a 1:1 ratio to either of the two groups. Fetuses in group A (n = 105) received acoustic stimulation after 10 min from the beginning of the CTG, whereas fetuses in group B received no stimulation (n = 105). The outcome variables investigated were the lapse of time between the beginning of the CTG and the occurrence of the first acceleration, and the lapse of time between the beginning of the CTG and the first fetal movement noticed. Results: The lapse of time between the beginning of the CTG and the occurrence of the first acceleration was significantly shorter in the group with acoustic stimulation compared to the other group (14.87 ± 5.01 vs. 21.90 ± 6.94 min, p-value < 0.001 log-rank test). Similarly, the lapse of time between the beginning of the CTG and the occurrence of the first fetal movement was significantly shorter in group A compared to group B (17.77 ± 7.62 vs. 23.28 ± 7.61 min, p-value < 0.001, log-rank test). Fetal cardiac acceleration and the occurrence of a fetal movement during the first 20 min of the CTG were more frequently recorded in group A compared to group B (respectively, 15% vs. 5% and 20% vs. 8%). Conclusion: This RCT showed an early fetal reaction following auditive stimulus, documentable by cardiotocography. Further research is needed to investigate a possible role of acoustic stimulation in utero for the prenatal diagnosis of congenital hypoacusis.
Mixing and Matching Emotion Frameworks: Investigating Cross-Framework Transfer Learning for Dutch Emotion Detection
Authors: De Bruyne Luna , De Clercq Orphée , Hoste Véronique
Published: November 2021

Emotion detection has become a growing field of study, especially seeing its broad application potential. Research usually focuses on emotion classification, but performance tends to be rather low, especially when dealing with more advanced emotion categories that are tailored to specific tasks and domains. Therefore, we propose the use of the dimensional emotion representations valence, arousal and dominance (VAD), in an emotion regression task. Firstly, we hypothesize that they can improve performance of the classification task, and secondly, they might be used as a pivot mechanism to map towards any given emotion framework, which allows tailoring emotion frameworks to specific applications. In this paper, we examine three cross-framework transfer methodologies: multi-task learning, in which VAD regression and classification are learned simultaneously; meta-learning, where VAD regression and emotion classification are learned separately and predictions are jointly used as input for a meta-learner; and a pivot mechanism, which converts the predictions of the VAD model to emotion classes. We show that dimensional representations can indeed boost performance for emotion classification, especially in the meta-learning setting (up to 7% macro F1-score compared to regular emotion classification). The pivot method was not able to compete with the base model, but further inspection suggests that it could be efficient, provided that the VAD regression model is further improved.
A 6.89-MHz 143-nW MEMS Oscillator Based on a 118-dBΩ Tunable Gain and Duty-Cycle CMOS TIA
Authors: Kira Ahmed , Elsayed Mohannad Y. , Allidina Karim , Chodavarapu Vamsy P. , El-Gamal Mourad N.
Published: November 2021

This article presents a 6.89 MHz MEMS oscillator based on an ultra-low-power, low-noise, tunable gain/duty-cycle transimpedance amplifier (TIA) and a bulk Lamé-mode MEMS resonator that has a quality factor (Q) of 3.24 × 106. Self-cascoding and current-starving techniques are used in the TIA design to minimize the power consumption and tune the duty-cycle of the output signal. The TIA was designed and fabricated in TSMC 65 nm CMOS process technology. Its open-loop performance has been measured separately. It achieves a tunable gain between 107.9 dBΩ and 118.1 dBΩ while dissipating only 143 nW from a 1 V supply. The duty-cycle of the output waveform can be tuned from 23.25% to 79.03%. The TIA has been interfaced and wire bonded in a series-resonant oscillator configuration with the MEMS resonator and mounted in a small cavity standard package. The closed-loop performance of the whole oscillator has been experimentally measured. It exhibits a phase noise of −128.1 dBc/Hz and −133.7 dBc/Hz at 1 kHz and 1 MHz offsets, respectively.
Zone-Agnostic Greedy Taxi Dispatch Algorithm Based on Contextual Matching Matrix for Efficient Maximization of Revenue and Profit
Authors: Kim Youngrae , Yoon Young
Published: November 2021

This paper addresses the taxi fleet dispatch problem, which is critical for many transport service platforms such as Uber, Lyft, and Didi Chuxing. We focus on maximizing the revenue and profit a taxi platform can generate through the dispatch approaches designed with various criteria. We consider determining the proportion of taxi fleets to different destination zones given the expected rewards from the future states following the distribution decisions learned through reinforcement learning (RL) algorithms. We also take into account more straightforward greedy algorithms that look ahead fewer decision time steps in the future. Our dispatch decision algorithms commonly leverage contextual information and heuristics using a data structure called Contextual Matching Matrix (CMM). The key contribution of our paper is the insight into the trade-off between different design criteria. Primarily, through the evaluation with actual taxi operation data offered by Seoul Metropolitan Government, we challenge the natural expectation that the RL-based approaches yield the best result by showing that a lightweight greedy algorithm can have a competitive advantage. Moreover, we break the norm of dissecting the service area into sub-zones and show that matching passengers beyond arbitrary boundaries generates significantly higher operating income and profit.
Detection of Security Attacks in Industrial IoT Networks: A Blockchain and Machine Learning Approach
Authors: Vargas Henry , Lozano-Garzon Carlos , Montoya Germán A. , Donoso Yezid
Published: November 2021

Internet of Things (IoT) networks have been integrated into industrial infrastructure schemes, positioning themselves as devices that communicate highly classified information for the most critical companies of world nations. Currently, and in order to look for alternatives to mitigate this risk, solutions based on Blockchain algorithms and Machine Learning techniques have been implemented separately with the aim of mitigating potential threats in IIoT networks. In this paper, we sought to integrate the previous solutions to create an integral protection mechanism for IoT device networks, which would allow the identification of threats, activate secure information transfer mechanisms, and it would be adapted to the computational capabilities of industrial IoT. The proposed solution achieved the proposed objectives and is presented as a viable mechanism for detecting and containing intruders in an IoT network. In some cases, it overcomes traditional detection mechanisms such as an IDS.
A Broadband Gain Amplifier Designed with the Models for Package and Diode Using 0.5 μm GaAs E-pHEMT Process
Authors: Kim Min-Su , Jhon Heesauk
Published: November 2021

This paper presents a 50 MHz to 5 GHz broadband gain amplifier using a 0.5 μm gallium-arsenide pseudomorphic high-electron-mobility-transistor (GaAs pHEMT). For broadband design, a high gain cascode structure with a feedback network was used. To ensure the robustness of the design, the amplifier had to consider the effects of the Electrostatic Discharge (ESD)-protected diode and the package, which can degrade the broadband performance. Therefore, the equivalent circuit models of the package and the ESD-protected diode were analyzed and simulated in this paper. The designed broadband gain amplifier from 50 MHz to 5 GHz frequency band has a die size of 700 μm × 1000 μm and consumes 156 mW of dc power, and it was simulated with a gain of 18.7 dB to 20.6 dB, a P1dB of 15.3 to 16.9 dBm, and a OIP3 of 26.5 to 31 dBm. Furthermore, the excellent gain flatness exhibited within 18.7 dB ± 1.92 dB at the interest of the frequency band.
Silica Sinter and the Evolution of Hot Springs in the Alvord/Pueblo Valleys, Southeast Oregon, USA
Authors: Mowbray Leslie Allen , Cummings Michael L.
Published: November 2021

Hot springs in the Alvord/Pueblo valleys in southeastern Oregon are analogous to Basin-and-Range hydrothermal systems where heat source and permeable pathways are met through crustal thinning. Silica sinter deposition at Mickey Springs, Alvord Valley, predates the late Pleistocene high stand of pluvial Lake Alvord. At Borax Lake, Pueblo Valley, sinter deposition occurred during the Holocene. This study examines the evolution of springs at Mickey Springs, where three morphologies of sinter are present: (1) basalt clasts surrounded by sinter in interbedded conglomerate and sandstone, (2) pool-edge and aprons of sinter surrounding depressions (12–32 m diameter), and (3) quaquaversal sinter mounds with pool-edge sinter. The oldest sinter occurs in silica-cemented conglomerate and sandstone, where deposition occurred prior to 30 kya. Deposition around broad depressions and mounds occurred after 30 kya but before water levels began to rise in pluvial Lake Alvord. Thermoluminescence dates suggest sinter deposition ceased before 18 kya when silt and clay filled inactive vents and buried aprons. A few mounds hosted active springs after sinter deposition ceased but while submerged in pluvial Lake Alvord. Now, high-temperature springs, steam vents, and mud pots are concentrated in a 50 × 50 m area near the southern edge of the spring area.
A Review on BGK Models for Gas Mixtures of Mono and Polyatomic Molecules
Authors: Pirner Marlies
Published: November 2021

We consider the Bathnagar–Gross–Krook (BGK) model, an approximation of the Boltzmann equation, describing the time evolution of a single momoatomic rarefied gas and satisfying the same two main properties (conservation properties and entropy inequality). However, in practical applications, one often has to deal with two additional physical issues. First, a gas often does not consist of only one species, but it consists of a mixture of different species. Second, the particles can store energy not only in translational degrees of freedom but also in internal degrees of freedom such as rotations or vibrations (polyatomic molecules). Therefore, here, we will present recent BGK models for gas mixtures for mono- and polyatomic particles and the existing mathematical theory for these models.
Significantly Different Lipid Profile Analysis of Litopenaeus vannamei under Low-Temperature Storage by UPLC-Q-Exactive Orbitrap/MS
Authors: Wang Shengnan , Chen Yongshi , Chen Yu , Liang Peng , Pang Jie , Zhu Beiwei , Dong Xiuping
Published: November 2021

Low-temperature storage is one of the most important preservation methods for aquatic product storage. However, the effects of low-temperature storage on the lipid profiles of shrimp are unclear. Herein, UPLC-Q-Exactive Orbitrap/MS combined with LipidSearch software was applied to analyze the effect of three low storage temperatures (4 °C, −2 °C, and −18 °C) on the lipidomics of Litopenaeus vannamei. A total of 15 lipid classes were analyzed, and PC, PE, DG, and TG accounted for vast majority of peak areas. Furthermore, 531 individual lipid variables enriched in 12 metabolic pathways were identified via bioinformatics analysis methods. A total of 56 significantly different lipid molecular species (55 belonging to PC, PE, DG, and TG) were selected as potential biomarkers of lipid oxidation via correlational analysis between physical properties (texture and color) and individual lipid variables. The results indicated that the three low storage temperatures caused different effects on the lipidomics profile of L. vannamei, and PC, PE, DG, and TG could become potential focuses in further studies of lipid oxidation in L. vannamei.
Different Withering Times Affect Sensory Qualities, Chemical Components, and Nutritional Characteristics of Black Tea
Authors: Ntezimana Bernard , Li Yuchuan , He Chang , Yu Xinlei , Zhou Jingtao , Chen Yuqiong , Yu Zhi , Ni Dejiang
Published: November 2021

The present study emphasizes the effect of withering time set at 4 ± 0.5 h (WT4), 6 ± 0.5 h (WT6), 8 ± 0.5 h (WT8), 10 ± 0.5 h (WT10), and 12 ± 0.5 h (WT12) on the sensory qualities, chemical components, and nutritional characteristics of black tea. The sensory evaluation revealed high total quality scores at WT8 and WT10. Polysaccharides, amino acids, and soluble sugars significantly increased with an increase in withering time, and an apparent peak value was obtained at WT10. However, polyphenols, flavonoids, glycosides, organic acids, catechins, alkanoids, and theaflavins decreased with an increase in withering time. With an increase in withering time, the content of aromatic substances showed a trend of increasing first and then decreasing. The peaks of alcohols, aldehydes, and acids appeared at 10 ± 0.5 h, 10 ± 0.5 h, and 8 ± 0.5 h, respectively. The content of esters, ketones, and hydrocarbons showed a downward trend with an increase in withering time. Aroma analysis revealed that withering time could not exceed 10 ± 0.5 h. Black tea withered up to WT10 showed enhanced inhibition of α-glucosidase and α-amylase activity with good sensorial attributes. Glucose uptake inhibition capacity increased up 6 ± 0.5 h and then decreased, while antioxidant capacity decreased with an increase in withering time. The overall results show that the 8 ± 0.5 h to 10 ± 0.5 h withering time could improve black tea quality and nutritional characteristics.
Nanotechnology as a Processing and Packaging Tool to Improve Meat Quality and Safety
Authors: Lamri Melisa , Bhattacharya Tanima , Boukid Fatma , Chentir Imene , Dib Amira Leila , Das Debashrita , Djenane Djamel , Gagaoua Mohammed
Published: November 2021

Nanoparticles are gaining momentum as a smart tool towards a safer, more cost-effective and sustainable food chain. This study aimed to provide an overview of the potential uses, preparation, properties, and applications of nanoparticles to process and preserve fresh meat and processed meat products. Nanoparticles can be used to reinforce the packaging material resulting in the improvement of sensory, functional, and nutritional aspects of meat and processed meat products. Further, these particles can be used in smart packaging as biosensors to extend the shelf-life of fresh and processed meat products and also to monitor the final quality of these products during the storage period. Nanoparticles are included in product formulation as carriers of health-beneficial and/or functional ingredients. They showed great efficiency in encapsulating bioactive ingredients and preserving their properties to ensure their functionality (e.g., antioxidant and antimicrobial) in meat products. As a result, nanoparticles can efficiently contribute to ensuring product safety and quality whilst reducing wastage and costs. Nevertheless, a wider implementation of nanotechnology in meat industry is highly related to its economic value, consumers’ acceptance, and the regulatory framework. Being a novel technology, concerns over the toxicity of nanoparticles are still controversial and therefore efficient analytical tools are deemed crucial for the identification and quantification of nanocomponents in meat products. Thus, migration studies about nanoparticles from the packaging into meat and meat products are still a concern as it has implications for human health associated with their toxicity. Moreover, focused economic evaluations for implementing nanoparticles in meat packaging are crucial since the current literature is still scarce and targeted studies are needed before further industrial applications.
Real-Time PCR Assay for the Detection and Quantification of Roe Deer to Detect Food Adulteration—Interlaboratory Validation Involving Laboratories in Austria, Germany, and Switzerland
Authors: Druml Barbara , Uhlig Steffen , Simon Kirsten , Frost Kirstin , Hettwer Karina , Cichna-Markl Margit , Hochegger Rupert
Published: November 2021

Game meat products are particularly prone to be adulterated by replacing game meat with cheaper meat species. Recently, we have presented a real-time polymerase chain reaction (PCR) assay for the identification and quantification of roe deer in food. Quantification of the roe deer content in % (w/w) was achieved relatively by subjecting the DNA isolates to a reference real-time PCR assay in addition to the real-time PCR assay for roe deer. Aiming at harmonizing analytical methods for food authentication across EU Member States, the real-time PCR assay for roe deer has been tested in an interlaboratory ring trial including 14 laboratories from Austria, Germany, and Switzerland. Participating laboratories obtained aliquots of DNA isolates from a meat mixture containing 24.8% (w/w) roe deer in pork, roe deer meat, and 12 meat samples whose roe deer content was not disclosed. Performance characteristics included amplification efficiency, level of detection (LOD95%), repeatability, reproducibility, and accuracy of quantitative results. With a relative reproducibility standard deviation ranging from 13.35 to 25.08% (after outlier removal) and recoveries ranging from 84.4 to 114.3%, the real-time PCR assay was found to be applicable for the detection and quantification of roe deer in raw meat samples to detect food adulteration.
Pre-Gelatinisation of Rice Flour and Its Effect on the Properties of Gluten Free Rice Bread and Its Batter
Authors: Ding Xiang-Li , Wang Lan-Jing , Li Ting-Ting , Wang Fei , Quan Zhen-Yang , Zhou Meng , Huo Zhong-Yang , Qian Jian-Ya
Published: November 2021

In order to improve the quality of the gluten free rice bread (GFRB), pre-gelatinised rice flour (PGRF) was made and used to partially replace natural rice flour in the production of GFRB. The pre-gelatinisation parameters were optimised and the effects of PGRF on the quality of the GFRB and its batter were studied. The results showed that optimal PGRF was obtained when 50% total water was mixed with 1.0% rice flour and the mixture heated at 80 °C for 2 min. Supplementation with PGRF significantly improved the properties of GFRB by affecting its baking properties, textural properties, colour, and crumb grain features. Effects of PGRF on GFRB were mainly caused by the more closely packed gel structure of rice starch in the bread batter, the higher onset temperature during gelatinisation and the complex effect of PGRF on water-binding capacity in bread batter during the baking process. As the pre-gelatinisation parameters of flours and their effect on gluten-free baked products varied with grain variety, processing properties should be studied before using them, and emphasis should be placed on new techniques such as flour pre-gelatinisation to obtain gluten-free foods with improved quality.
Consumer Profile and Drivers Influencing Consumer Behavior towards Fondillón, a European Protected Naturally Sweet Red Wine
Authors: Issa-Issa Hanán , Noguera-Artiaga Luis , Mora María , Carbonell-Barrachina Ángel A. , López-Lluch David
Published: November 2021

Fondillón is a naturally sweet red wine, protected within the Alicante Denomination of Origin (Alicante, Spain) and recognized by the European Union in its E-Bacchus database. The aims of this study were (i) to evaluate the degree of consumer acceptance and satisfaction towards Fondillón, (ii) to establish key drivers controlling consumer satisfaction, and (iii) to establish a general profile of the typical Fondillón consumer. The experiment consisted of three complementary studies: (i) a descriptive sensory analysis of five Fondillón samples representing all samples being marketed, (ii) an affective test using wine consumers (n = 100), and (iii) an online questionnaire to identify the main characteristic of a Fondillón consumer (n = 294). The main consumption drivers were good balance, intense floral and fruity notes, and long aftertaste. The current typical Fondillón consumer is a 42–52 year-old man, with a higher education level, with a 25,000–50,000 euros/year income, and who drinks it mainly at home. The online study showed that 50% of respondents do not consume Fondillón because they do not know it, because it is very expensive, or because it is not so easy to find. Therefore, producers should improve their communication campaigns and distribution networks as key parts of their marketing strategies regarding Fondillón.
Fabrication, Structure and Functional Characterizations of pH-Responsive Hydrogels Derived from Phytoglycogen
Authors: Hu Xiuting , Liu Yao , Chen Yimei , Zhang Tao , Miao Ming
Published: November 2021

The pH-responsive hydrogels were obtained through successive carboxymethylation and phosphorylase elongatation of phytoglycogen and their structure and functional characterizations were investigated. Phytoglycogen (PG) was first carboxymethylated to obtain carboxymethyl phytoglycogen (CM-PG) with degree of substitution (DS) at 0.15, 0.25, 0.30, and 0.40, respectively. Iodine staining and X-ray diffraction analysis suggested that the linear glucan chains were successfully phosphorylase-elongated from the non-reducing ends at the CM-PG surface and assembled into the double helical segments, leading to formation of the hydrogel. The DS of CM-PG significantly influenced elongation of glucan chains. Specifically, fewer glucan chains were elongated for CM-PG with higher DS and the final glucan chains were shorter, resulting in lower gelation rate of chain-elongated CM-PG and lower firmness of the corresponding hydrogels. Scanning electron microscope observed that the hydrogels exhibited a porous and interconnected morphology. The swelling ratio and volume of hydrogels was low at pH 3–5 and then became larger at pH 6–8 due to electrostatic repulsion resulting from deprotonated carboxymethyl groups. Particularly, the hydrogel prepared from chain-elongated CM-PG (DS = 0.25) showed the highest sensitivity to pH. These results suggested that phosphorylase-treated CM-PG formed the pH-responsive hydrogel and that the elongation degree and the properties of hydrogels depended on the carboxymethylation degree. Thus, it was inferred that these hydrogels was a potential carrier system of bioactive substances for their targeted releasing in small intestine.
Development of Indirect Competitive ELISA and Visualized Multicolor ELISA Based on Gold Nanorods Growth for the Determination of Zearalenone
Authors: Ma Tianyu , Liu Kaixin , Yang Xiao , Yang Jingying , Pan Mingfei , Wang Shuo
Published: November 2021

In this study, a zearalenone (ZEN) hapten was designed and prepared against the mycotoxin ZEN, and the original coating ZEN-ovalbumin (ZEN-OVA) was prepared by conjugation with OVA. Based on the gold nanorods (AuNRs) of uniform size and stable properties synthesized by the seed-mediated method, the indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) and the AuNRs growth-based multicolor ELISA for detecting ZEN toxin were further established. Under the optimal experimental conditions, the coating amount of ZEN-OVA: 0.025 μg/well, antibody (Ab) dilution factor: 32,000 times, blocking solution: 0.5% skimmed milk powder, enzyme-labeled secondary Ab diluted 10,000 times, and a pH of the PBS buffer at 7.4, the sensitivity (IC50) of the established ic-ELISA for ZEN detection reached 0.85 ± 0.04 μg/L, and the limit of detection (IC15) reached 0.22 ± 0.08 μg/L. In the multicolor ELISA based on the growth of AuNRs, as the content of ZEN increased, the mixed solution exhibited a significant color change from brownish red to colorless. ZEN concentration as low as 0.1 μg/L can be detected by the naked eye (brown red to dark gray). This study provided an effective analysis strategy for the rapid screening and accurate monitoring of the ZEN contaminant in foods.
Product Authentication Using Two Mitochondrial Markers Reveals Inconsistent Labeling and Substitution of Canned Tuna Products in the Taiwanese Market
Authors: Chang Chia-Hao , Kao Yueh-Tzu , Huang Ting-Ting , Wang Yu-Chun
Published: November 2021

Fish of the tribe Thunnini represent a significant proportion of the stock caught by the fishing industry, with many of these fishes being collectively called tuna. However, only certain species can be used legally as an ingredient in canned tuna products, depending on regional food regulations. In Taiwan, only Thunnus species or Katsuwonus pelamis can be used as canned tuna. Here, we authenticated 90 canned tuna products, including 25 cat food samples, by sequencing two mitochondrial regions, 16S rRNA (16S) and the control region (CR). BLAST analysis revealed that Sarda orientalis, Euthynnus affinis, Auxis rochei, and Auxis thazard are all used as substitutes for legitimate tuna products. We found that 63.33% of investigated samples are true canned tuna, i.e., contain Thunnus species or skipjack tuna. We advocate that the Taiwanese government publishes an official standardized list of fishes, especially so that scientific, Chinese and vernacular names can be assigned unambiguously based on a “one species-one name policy”, thereby clarifying which species can be used in seafood products such as tuna. Furthermore, we feel that the large-scale and long-term monitoring of canned tuna products is warranted to fully assess the extent of tuna product adulteration in Taiwan.
Effect of Light Characteristics on the Sensory Properties of Red Lettuce (Lactuca sativa)
Authors: Gude Kelly , Talavera Martin , Sasse Audra M. , Rivard Cary L. , Pliakoni Eleni
Published: November 2021

Leafy green production in high tunnels (HTs) results in increased yields, improved visual quality, and extended production with polyethylene (poly) film and/or shade cloth coverings. However, altering visible and ultra-violet light with HT coverings may reduce phytochemicals, thus influencing plant pigmentation and taste. The objective of this study was to examine various HT coverings on the sensory perceptions, soil temperature, color, and anthocyanin accumulation of red leaf lettuce. The coverings included standard poly, standard poly with removal two weeks prior to harvest (movable), diffuse poly, clear poly, UV-A/B blocking poly (block), standard poly with 55% shade cloth, and the open field. A highly trained descriptive panel evaluated the samples using a scale from 0 (none) to 15 (extremely high) and determined a list of 20 sensory attributes. The color intensity attribute had the most differentiation between coverings, and the open field was higher (i.e., darker) than the others at 7.5 (p < 0.0001), followed by clear and movable coverings at 6.8, and the shade covering scored a 2. Strong relationships existed between both colorimetric (hue°) and anthocyanin analysis to panelist-based scores (R2 = 0.847 and 0.640, respectively). The initial crispness was similar for movable, standard, diffuse, and block coverings at 5.3 on average, which was higher than the open field at 4 (p < 0.01). The open field lettuce grew under cooler soil temperatures, which may have slowed down maturation and resulted in softer tissue. Based on this study, HT growers can implement specific coverings to cater to markets that value visual quality.
Role of Hydrothermal Fluids in the Formation of the Kamioka Skarn-Type Pb–Zn Deposits, Japan
Authors: Morishita Yuichi , Wada Ayaka
Published: November 2021

The Kamioka mine, located in Gifu Prefecture in Japan, is famous for the large water Cherenkov detector system, the Super-Kamiokande. The Kamioka skarn-type Pb–Zn deposits are formed in crystalline limestone and are replaced by skarn minerals within the Hida metamorphic rocks. The Kamioka deposits mainly consist of the Tochibora, Maruyama, and Mozumi deposits. The present study focuses on the ore-forming hydrothermal fluid activity in the Kamioka deposits and the peripheral exploration area based on the carbon and oxygen isotope ratios of calcite and rare earth element (REE) analyses. The carbon and oxygen isotope ratios of crystalline limestone (as the host rock) are not homogeneous, and depending on the degree of hydrothermal activity, they decreased to various degrees because of the reaction with the ore fluids. Thus, the carbon and oxygen isotope ratios of crystalline limestone can be used as an indicator of the influence of the hydrothermal fluids for the ore mineralization. The REE contents in the ores of igneous origin are one order of magnitude higher than the limestone origin. Further, depending on the formation temperatures, calcites precipitated during ore mineralization have a stable carbon isotope ratio and a widely varying oxygen isotope ratios. The Kamioka district fracture system is likely a major control factor on ore mineralization from hydrothermal activity. In addition, the skarnization-related ore-forming fluids are mostly meteoric in origin, confirming the conclusions from previous studies.
Examining the Effects of Suction and Nonlinear Strength Envelopes on the Stability of a High Plasticity Clay Slope
Authors: Xuan Mengwei , Montgomery Jack , Anderson J. Brian
Published: November 2021

Slope failures in high plasticity clay deposits are common occurrences in many parts of the world. In western and central Alabama, expansive Prairie clays are commonly found, and shallow slope failures have occurred in both fill and cut slopes containing these high plasticity clays. The objective of this study was to examine the effects of suction and the use of nonlinear strength envelopes on the embankment stability of a section of highway AL-5. The testing program consisted of fifteen ring shear tests performed using a Bromhead Ring Shear Device. The results of the tests were used to develop both linear and nonlinear fully softened and residual strength envelopes. The saturated strength envelopes are then used in a limit equilibrium slope stability analysis with and without the effects of suction. The results show stability (factor of safety >1) for all cases except the residual friction angle without suction. Given these results, large slope failures are unlikely to occur in this area, but surficial failures and deformations due to creep may be possible. These results demonstrate the importance of considering the effects of suction and nonlinear strength envelopes when examining the potential for shallow slope failures in high plasticity clays.
Seismic Activity of the Manisa Fault Zone in Western Turkey Constrained by Cosmogenic 36Cl Dating
Authors: Mozafari Nasim , Özkaymak Çağlar , Tikhomirov Dmitry , Ivy-Ochs Susan , Alfimov Vasily , Sözbilir Hasan , Schlüchter Christian , Akçar Naki
Published: November 2021

This study reports on the cosmogenic 36Cl dating of two normal fault scarps in western Turkey, that of the Manastır and Mugırtepe faults, beyond existing historical records. These faults are elements of the western Manisa Fault Zone (MFZ) in the seismically active Gediz Graben. Our modeling revealed that the Manastır fault underwent at least two surface ruptures at 3.5 ± 0.9 ka and 2.0 ± 0.5 ka, with vertical displacements of 3.3 ± 0.5 m and 3.6 ± 0.5 m, respectively. An event at 6.5 ± 1.6 ka with a vertical displacement of 2.7 ± 0.4 m was reconstructed on the Mugırtepe fault. We attribute these earthquakes to the recurring MFZ ruptures, when also the investigated faults slipped. We calculated average slip rates of 1.9 and 0.3 mm yr−1 for the Manastır and Mugırtepe faults, respectively.
Metamorphic Conditions and Raman Spectroscopic Carbonaceous Material Thermometry of Host Schists of Olympiada and Eldorado Gold Deposits (Yenisey Ridge, Russia)
Authors: Sukhorukov Vasiliy , Volkova Valeriya , Nevolko Peter , Kozlov Pavel
Published: November 2021

Metamorphic processes play a key role in forming orogenic gold deposits. In this paper, we present new evidence that host schists of the two largest gold deposits of the Yenisey ridge (Russia) Olympiada and Eldorado underwent a single stage of metamorphism in contrast to surrounding blocks. This metamorphism is of moderate thermal gradient and belongs to the Barrovian type, which is typical for the collisional event in the time range 800–850 Ma. The new Ar/Ar age data presented in this paper and the review of magmatic and metamorphic events and ore-forming processes indicate that the most productive stage (gold-sulfide-quartz) correlates well in time with the regional metamorphism of the Barrovian type. This indicates that metamorphic processes can have a crucial role in forming gold deposits of the Yenisey ridge. Carbonaceous material thermometry indicates a wide range of obtained temperatures around 90–150 °C around the mean temperature for each sample. The highest temperatures are close to the peak metamorphic temperatures estimated by garnet-biotite thermometry.
Machine Learning for Predicting the Risk for Childhood Asthma Using Prenatal, Perinatal, Postnatal and Environmental Factors
Authors: Jeddi Zineb , Gryech Ihsane , Ghogho Mounir , EL Hammoumi Maryame , Mahraoui Chafiq
Published: November 2021

The prevalence rate for childhood asthma and its associated risk factors vary significantly across countries and regions. In the case of Morocco, the scarcity of available medical data makes scientific research on diseases such as asthma very challenging. In this paper, we build machine learning models to predict the occurrence of childhood asthma using data from a prospective study of 202 children with and without asthma. The association between different factors and asthma diagnosis is first assessed using a Chi-squared test. Then, predictive models such as logistic regression analysis, decision trees, random forest and support vector machine are used to explore the relationship between childhood asthma and the various risk factors. First, data were pre-processed using a Chi-squared feature selection, 19 out of the 36 factors were found to be significantly associated (p-value < 0.05) with childhood asthma; these include: history of atopic diseases in the family, presence of mites, cold air, strong odors and mold in the child’s environment, mode of birth, breastfeeding and early life habits and exposures. For asthma prediction, random forest yielded the best predictive performance (accuracy = 84.9%), followed by logistic regression (accuracy = 82.57%), support vector machine (accuracy = 82.5%) and decision trees (accuracy = 75.19%). The decision tree model has the advantage of being easily interpreted. This study identified important maternal and prenatal risk factors for childhood asthma, the majority of which are avoidable. Appropriate steps are needed to raise awareness about the prenatal risk factors.
Easy to Read Health Education Material Improves Oral Health Literacy of Older Adults in Rural Community-Based Care Centers: A Quasi-Experimental Study
Authors: Sun Kuo-Ting , Shieh Tzong-Ming , Hsia Shih-Min , Ningrum Valendriyani , Lin Xin-Yi , Shih Yin-Hwa
Published: November 2021

Health education increases older adults’ health knowledge and affects their health outcomes. Older adults have physical changes with aging, such as blurred vision and cognitive decline. Therefore, health education materials must be legible in their case. This study, following the “easy (EZ) to read” concept, designed oral health education material and tested the learning effectiveness of older adults in rural community-based care centers in central Taiwan. Three of the communities were provided EZ to read health education material (n = 72), while three were given general text material (n = 57) as the control group. We collected pre-test and post-test scores using the Mandarin version of the oral health literacy adult questionnaire (MOHL-AQ). The demographic background of the EZ to read and general text groups showed no significant difference (p > 0.05). Analysis of covariance (ANCOVA) showed that the EZ to read material significantly improved total scores of oral health literacy (p < 0.001). The chi-square test showed a significant improvement in oral health literacy levels (p < 0.001). We suggest applying EZ to read concepts to widen the field of older adult education and to reduce illegibility-induced health knowledge disparities.
Using a Socio-Environmental Approach to Explore the Determinants for Meeting the Recommended Physical Activity among Adults at Risk of Diabetes in Rural Indonesia
Authors: Widiantoro Fransiskus Xaverius , Wang Jing-Jy , Yang Yi-Ching , Chou Cheng-Chen , Wang Chi-Jane
Published: November 2021

Moderate-to-vigorous physical activity (PA) is recommended to mitigate the risk of diabetes. This study explored the PA of adults at risk for diabetes in rural Indonesia and determined the requirements for meeting the recommended PA level. In total, 842 adults were screened using a diabetes risk test in a rural health centre; among them, 342 were at risk of diabetes. The level of PA was assessed using the International Physical Activity Questionnaire, whereas the associated factors underlying the three domains –individual, support, and environment—were determined by the Influences on Physical Activity Instrument. The data analysis included a three-step multiple linear regression (MLR) and logistic regression (LR). Overall, 40.6% of the participants met the recommended PA. According to the MLR analysis, among males, individuals who gave PA a higher priority and had enough time to perform PA were predicted to have a higher activity energy expenditure (MET-minutes per week). According to the LR analysis, men were more likely to meet the recommended PA, and people who gave PA a lower priority and had less access to space for PA were less likely to meet the recommended PA level. Strategies for promoting PA in rural Indonesia include focusing on women, people who prioritize PA less, and those who have less time and space in which to be physically active.