bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-Angiogenesis Maintenance Therapy in Newly Diagnosed and Relapsed Ovarian Cancer: A Meta-analysis of Phase III Randomized Controlled Trials
Authors: Wang Yizi , Zhang Shitai , Song Zixuan , Ouyang Ling , Li Yan
Published: November 2021

Aim: Anti-angiogenesis agents have been added as maintenance therapy in ovarian cancer over the past decade. The aim of this meta-analysis was to analyze the efficacy of anti-angiogenesis therapy in newly diagnosed and relapsed ovarian cancer.

Methods: PubMed, Embase, and Cochrane databases were searched for all phase III randomized controlled trials (RCTs) that assessed the efficacy and toxicity of anti-angiogenesis agents in ovarian cancer. Overall survival (OS) and progression-free survival (PFS) were used to evaluate the effectiveness of anti-angiogenesis therapy in ovarian cancer.

Results: A total of 6097 patients with newly diagnosed ovarian cancer from 5 phase III RCTs and 2943 patients with relapsed ovarian cancer from 6 phase III RCTs were included in this meta-analysis. The pooled results showed that anti-angiogenesis maintenance therapy significantly improved PFS (hazard ratio [HR], 0.84; 95% confidence interval [CI], 0.76–0.93; p = 0.001), but not OS (HR, 0.98; 95% CI, 0.91–1.05; p = 0.49) compared with placebo in patients with newly diagnosed ovarian cancer. In patients with relapsed ovarian cancer, the pooled results showed a significant improvement on OS (HR, 0.89; 95% CI, 0.82–0.98; p = 0.02) and PFS (HR, 0.61; 95% CI, 0.52–0.72; p < 0.001). The pooled results also showed that the anti-angiogenesis agents were associated with an increase in the occurrence of severe hypertension, neutropenia, diarrhea, thrombocytopenia, headache, and bleeding in ovarian cancer. However, infrequent fatal adverse events occurred in the anti-angiogenesis groups.

Conclusions: Study results suggest that anti-angiogenesis agents were an effective therapy for newly diagnosed and relapsed ovarian cancer, especially for relapsed ovarian cancer. Anti-angiogenesis agents may be associated with some severe but not fatal adverse events.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42021283647
The Stressful Life of the Urban Consumers: The Case of Dhaka City Residents
Authors: Masoom Muhammad Rehan
Published: November 2021

The present research examines the metropolitan mental life of consumers of Dhaka, which is one of the most densely populated and least livable cities in the world. Though mental life encompasses a range of factors, the study considered the dynamic interplays of the most pertinent ones, such as perceived stress, the sense of control, materialistic values, and religiosity. These variables were measured and quantified by commonly used measurement tools; a recursive structural equation model was constructed to unearth the causal connections among those variables. By using a 57-item questionnaire, the study surveyed 1,068 shoppers living in 10 different zones of the city. The estimated covariance by the multivariate structural equation model indicates that perceived stress is significantly associated with the sense of control, while religiosity and materialistic value-orientation were negatively associated. However, there are no significant relationships between religiosity and sense of control, and materialism and sense of control. Perceived stress and religiosity are found to be positively associated. The estimated independent samplet-tests showed that while no significant difference is found in sense of control by gender, women were more religious, less materialistic, but perceive their lives as more stressful than the men. The findings help to interpret both the cognitive and affective responses of the consumers of urban residents.
Barriers and Facilitators to Seeking Sleep Solutions for Children With Cerebral Palsy: A Qualitative Study
Authors: Petersen Sacha , Reddihough Dinah S. , Lima Sally , Harvey Adrienne , Newall Fiona
Published: November 2021

Background: Published evidence to date suggests that sleep problems are common in children with cerebral palsy (CP). This qualitative study is a follow up to a previously published quantitative phase on the experience and impact of sleep problems in this population.

Aims: The aim of this study was to explore the experience and impact of sleep disturbance and seeking of sleep solutions for parents of school aged children with CP.

Materials and Methods: Semi-structured 19 qualitative interviews were conducted with parents of children with CP aged 6–12 years. Interview data were transcribed verbatim and the thematic analysis techniques by Braun and Clarke was used to identify themes.

Results: Thematic analysis identified 7 themes: (1) My Child Doesn't Fit into the Box, (2) A Mother's Ears are Always On, (3) Sleep Disturbance is like Water Torture, (4) Sleep is One of Many Spot Fires, I Put it on the Backburner, (5) Luck, Money or Jumping Up and Down, (6) There is Never One Silver Bullet and (7) Help: The Earlier the Better. The key finding was that parents of children with CP often described their child's needs being distinct from what is provided by systems and services.

Conclusion: Parents face significant challenges sourcing effective sleep solutions for their child with CP. Sleep is often not a priority for either the parent or the clinician as other health problems take precedence. Parents reflected that early sleep intervention for their child was or would have been helpful. The barriers and facilitators to sleep care identified in this study should be used to inform clinical change in care for children with CP. Sleep needs to be prioritized in healthcare for children.
Following the Epidemic Waves: Child and Youth Mental Health Assessments in Ontario Through Multiple Pandemic Waves
Authors: Stewart Shannon L. , Vasudeva Aadhiya S. , Van Dyke Jocelyn N. , Poss Jeffrey W.
Published: November 2021

Emerging studies across the globe are reporting the impact of COVID-19 and its related virus containment measures, such as school closures and social distancing, on the mental health presentations and service utilization of children and youth during the early stages of lockdowns in their respective countries. However, there remains a need for studies which examine the impact of COVID-19 on children and youth's mental health needs and service utilization across multiple waves of the pandemic. The present study used data from 35,162 interRAI Child and Youth Mental Health (ChYMH) assessments across 53 participating mental health agencies in Ontario, Canada, to assess the mental health presentations and referral trends of children and youth across the first two waves of the COVID-19 pandemic in the province. Wave 1 consisted of data from March to June 2020, with Wave 2 consisting of data from September 2020 to January 2021. Data from each wave were compared to each other and to the equivalent period one year prior. While assessment volumes declined during both pandemic waves, during the second wave, child and youth assessments in low-income neighborhoods declined more than those within high-income neighborhoods. There were changes in family stressors noted in both waves. Notably, the proportion of children exposed to domestic violence and recent parental stressors increased in both waves of the pandemic, whereas there were decreases noted in the proportion of parents expressing feelings of distress, anger, or depression and reporting recent family involvement with child protection services. When comparing the two waves, while depressive symptoms and recent self-injurious attempts were more prevalent in the second wave of the pandemic when compared to the first, a decrease was noted in the prevalence of disruptive/aggressive behaviors and risk of injury to others from Wave 1 to Wave 2. These findings highlight the multifaceted impact of multiple pandemic waves on children and youth's mental health needs and underscore the need for future research into factors impacting children and youth's access to mental health agencies during this time.
Physiological and Agronomic Traits of Certain Sugarcane Genotypes Grown under Field Conditions as Influenced by Early Drought Stress
Authors: Leanasawat Nithaya , Kosittrakun Manit , Lontom Watanachai , Songsri Patcharin
Published: November 2021

Drought is one of the important problems that drastically affect sugarcane production in several countries. The objective of this research was to investigate the effects of early drought stress on physiological parameters and agronomic traits of six sugarcane genotypes under field conditions. The experiment was arranged in a split plot in a completely randomized block design with three replications. The main plot was represented by three different water regimes: field capacity (FC), ½FC and rain-fed (RF), whereas the subplot consisted of six sugarcane genotypes: KK3 (drought tolerant), Q117 (drought tolerant), LK92-11 (drought susceptible), Ths98-271 (S. spontaneum), KK08-214 (the F1 hybrid derived from S. spontaneum × S. officinarum) and E08-4-019 (the F1 hybrid derived from Erianthus sp. × S. officinarum). The six sugarcane genotypes were subjected to three irrigation treatments. The 45-day-old plants of all sugarcane genotypes were exposed to drought by withholding water for 72 days. Certain photosynthetic parameters were measured in the leaves of four-month-old plants. Certain cane yield parameters were measured in the 12-month-old plants. The results showed that early drought stress decreased the maximum quantum yield of PSII efficiency, net photosynthetic rate, transpiration rate and stomatal conductance. Drought stress significantly (p ≤ 0.01) decreased cane yield. The cane yield and sugar yield of KK3 were significantly (p ≤ 0.01) higher than those of the other genotypes. The wild-type sugarcane and the F1 hybrids derived from the wild and commercial sugarcane could maintain better photosynthetic performance while encountering early drought stress.
Regulation of Phosphorus and Zinc Uptake in Relation to Arbuscular Mycorrhizal Fungi for Better Maize Growth
Authors: Saboor Abdul , Ali Muhammad Arif , Husain Shabir , Tahir Muhammad Saeed , Irfan Muhammad , Bilal Muhammad , Baig Khurram Shehzad , Datta Rahul , Ahmed Niaz , Danish Subhan , Glick Bernard R.
Published: November 2021

Zinc (Zn) is an important micronutrient for plants, whose deficiency in alkaline soils creates hurdles in the achievement of optimum crop growth. Moreover, overuse of phosphorus (P) fertilizers often causes Zn immobilization in the soil. The employment of arbuscular mycorrhizal fungi (AMF) could be potentially environmentally friendly technology in this regard. Therefore, a pot experiment was conducted to assess the beneficial role of AMF (Glomus species) on maize under low and high P and Zn levels. Seven levels of Zn (0, 20, 40, 60, 80, 100 and 120 mg Zn kg−1 soil ZnSO4·7H2O) and three levels of P (0, 14.5, 29 and 58 kg ac−1 as single superphosphate) were applied with (M+) and without AMF (M−). The results showed that a high application rate of Zn (100 and 120 mg Zn kg−1 soil) restricted P translocation in plants and vice versa. Moreover, the nutritional status of mycorrhizal plants (AM) was better than non-mycorrhizal (NM) plants. AM plants showed a maximum positive response at 20 mg Zn kg−1 soil, or 29 kg P ac−1. In response to 20 mg Zn kg−1 soil, root colonization was maximum, which enhanced the maize nutrient concentration in shoots. In conclusion, AMF inoculation (M+) with P (29 kg ac−1) and Zn (20 mg kg−1) is efficacious for improving maize’s growth and nutrition. More investigations are suggested at the field level under different agroclimatic zones to ascertain whether P (29 kg ac−1) or Zn (20 mg kg−1) with AMF is the best treatment for maize growth optimization.
Direct and Indirect Effects of Invasive vs. Native Ant-Hemipteran Mutualism: A Meta-Analysis That Supports the Mutualism Intensity Hypothesis
Authors: Wang Bo , Lu Min , Peng Yan-Qiong , Segar Simon T.
Published: November 2021

Mutualism can facilitate the colonization, establishment, and spread of invasive species. By modifying interactions with third parties, mutualisms can have cascading community-wide effects. Both native and invasive ants are capable of forming mutualisms with hemipteran insects, preying on non-hemipteran herbivores and indirectly affecting primary production. Comparative research on the effects of both native and invasive ant exclusions on multitrophic interactions is therefore crucial for understanding the invasive potential of ants, along with any ecological consequences that invasions may have. We performed a quantitative review of the multitrophic effects of invasive and native ants on insect–plant food webs. Herbivorous insects are the most common food source for both invasive (comprising 56% of prey species caught) and native ants (55% of the prey species caught), followed by predators (31% for invasive ants, 45% for native ants). Excluding both invasive and native ants significantly reduced hemipteran abundance, and excluding invasive ants had a greater negative impact on hemipteran abundance than native ants. Native ant predation significantly reduced herbivore abundance, but excluding invasive ants had no effect. Cascading effects of native ants on plant fitness were significantly positive, but there was no significant impact of invasive ants. These findings suggest a weak relationship between the presence of invasive ants and non-hemipteran herbivore abundance. We suggest that the hemipteran–ant mutualism could represent a ‘symbiotic invasion’. The ecological dominance of invasive ants is often facilitated by hemipteran insects. This association requires invasive ant control strategies to expand beyond ants to consider mutualists.
Advanced Technologies for the Optimization of Internal Combustion Engines
Authors: Tornatore Cinzia , Marchitto Luca
Published: November 2021

Even in a scenario where electric vehicles gain market share and the sale of internal combustion engines is gradually reduced, at the present time, there are still no real options that can totally replace the internal combustion (IC) engine over the entire range of its applications [...]
Digitalization in Open-Pit Mining: A New Approach in Monitoring and Control of Rock Fragmentation
Authors: Koteleva Natalia , Khokhlov Sergei , Frenkel Ilia
Published: November 2021

Mining enterprises are widely introducing digital technologies and automation is one of such tools. Granularity monitoring, namely, the size determination of rock mass pieces is a common operational component of the processes that extract minerals by open-pit mining. The article proposes an approach that, in addition to the lump size distribution, makes it possible to estimate the lump form distribution as well. To investigate the effectiveness of monitoring the form of blasted rock mass lumps, the authors conducted experiments in four stages related to the rock condition. They include geological occurrence, explosive crushing, trommelling, and mill crushing. The relationship between these stages is presented and the change in the lumps fragment form is traced. The present article proposes an informational and analytical model of the processes at mining enterprises, extracting minerals by open-pit mining, as well as an algorithm for determining the lumps form and obtaining their distribution in the rock mass.
Taphonomic and Diagenetic Pathways to Protein Preservation, Part I: The Case of Tyrannosaurus rex Specimen MOR 1125
Authors: Ullmann Paul V. , Macauley Kyle , Ash Richard D. , Shoup Ben , Scannella John B.
Published: November 2021

Many recent reports have demonstrated remarkable preservation of proteins in fossil bones dating back to the Permian. However, preservation mechanisms that foster the long-term stability of biomolecules and the taphonomic circumstances facilitating them remain largely unexplored. To address this, we examined the taphonomic and geochemical history of Tyrannosaurus rex specimen Museum of the Rockies (MOR) 1125, whose right femur and tibiae were previously shown to retain still-soft tissues and endogenous proteins. By combining taphonomic insights with trace element compositional data, we reconstruct the postmortem history of this famous specimen. Our data show that following prolonged, subaqueous decay in an estuarine channel, MOR 1125 was buried in a coarse sandstone wherein its bones fossilized while interacting with oxic and potentially brackish early-diagenetic groundwaters. Once its bones became stable fossils, they experienced minimal further chemical alteration. Comparisons with other recent studies reveal that oxidizing early-diagenetic microenvironments and diagenetic circumstances which restrict exposure to percolating pore fluids elevate biomolecular preservation potential by promoting molecular condensation reactions and hindering chemical alteration, respectively. Avoiding protracted interactions with late-diagenetic pore fluids is also likely crucial. Similar studies must be conducted on fossil bones preserved under diverse paleoenvironmental and diagenetic contexts to fully elucidate molecular preservation pathways.
Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production
Authors: Yang Jiao , Li Changfu , Zhang Yansheng
Published: November 2021

24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we engineered the biosynthesis of 24-methylene-cholesterol in Saccharomyces cerevisiae by disrupting the two enzymes (i.e., ERG4 and ERG5) in the yeast’s native ergosterol pathway, with ERG5 being replaced with the DHCR7 (7-dehydrocholesterol reductase) enzyme. Three versions of DHCR7 originating from different organisms—including the DHCR7 from Physalis angulata (PhDHCR7) newly discovered in this study, as well as the previously reported OsDHCR7 from Oryza sativa and XlDHCR7 from Xenopus laevis—were assessed for their ability to produce 24-methylene-cholesterol. XlDHCR7 showed the best performance, producing 178 mg/L of 24-methylene-cholesterol via flask-shake cultivation. The yield could be increased up to 225 mg/L, when one additional copy of the XlDHCR7 expression cassette was integrated into the yeast genome. The 24-methylene-cholesterol-producing strain obtained in this study could serve as a platform for characterizing the downstream enzymes involved in the biosynthesis of physalin or withanolide, given that 24-methylene-cholesterol is a common precursor of these chemicals.
Characterization of the Biomechanical Properties of Skin Using Vibrational Optical Coherence Tomography: Do Changes in the Biomechanical Properties of Skin Stroma Reflect Structural Changes in the Extracellular Matrix of Cancerous Lesions?
Authors: Silver Frederick H. , Kelkar Nikita , Deshmukh Tanmay , Ritter Kelly , Ryan Nicole , Nadiminti Hari
Published: November 2021

Early detection of skin cancer is of critical importance since the five-year survival rate for early detected skin malignancies is 99% but drops to 27% for cancer that has spread to distant lymph nodes and other organs. Over 2.5 million benign skin biopsies (55% of the total) are performed each year in the US at an alarming cost of USD ~2.5 B. Therefore there is an unmet need for novel non-invasive diagnostic approaches to better differentiate between cancerous and non-cancerous lesions, especially in cases when there is a legitimate doubt that a biopsy may be required. The purpose of this study is to determine whether the differences in the extracellular matrices among normal skin, actinic keratosis (AK), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) can be assessed non-invasively using vibrational optical coherence tomography (VOCT). VOCT is a new diagnostic technology that uses infrared light and audible sound applied transversely to tissue to measure the resonant frequencies and elastic moduli of cells, dermal collagen, blood vessels and fibrous tissue in skin and lesion stroma without physically touching the skin. Our results indicate that the cellular, vascular and fibrotic resonant frequency peaks are altered in AK, BCC and SCC compared to those peaks observed in normal skin and can serve as physical biomarkers defining the differences between benign and cancerous skin lesions. The resonant frequency is increased from a value of 50 Hz in normal skin to a value of about 80 Hz in pre- and cancerous lesions. A new vascular peak is seen at 130 Hz in cancerous lesions that may reflect the formation of new tumor blood vessels. The peak at 260 Hz is similar to that seen in the skin of a subject with Scleroderma and skin wounds that have healed. The peak at 260 Hz appears to be associated with the deposition of large amounts of stiff fibrous collagen in the stroma surrounding cancerous lesions. Based on the results of this pilot study, VOCT can be used to non-invasively identify physical biomarkers that can help differentiate between benign and cancerous skin lesions. The appearance of new stiff cellular, fragile new vessels, and stiff fibrous material based on resonant frequency peaks and changes in the extracellular matrix can be used as a fingerprint of pre- and cancerous skin lesions.
Life Cycle Assessment of Different Prefabricated Rates for Building Construction
Authors: Wang Shaozhe , Sinha Rajib
Published: November 2021

In recent years, Sweden has promoted prefabricated buildings supporting the increasing of prefabricated rates in buildings with precast components, in order to reduce the environmental problems caused by the construction sector. This study, focusing on the construction activities, examines how the increasing prefabricated rate could influence the environmental impacts of the construction sector. This study conducts a cradle-to-gate life cycle assessment (LCA) of a reference building with a prefabricated rate of 26% in the Stockholm Royal Seaport, and compares nine scenarios with prefabricated rates, ranging from 6% to 96%. The results indicate the water footprint decreases, but the total energy footprint and carbon footprint increase as the prefabricated rate increases. Among other impacts, terrestrial ecotoxicity shows the biggest increase with an increase of the prefabricated rate. This study reveals that material extraction is the largest influencing factor, causing a water footprint when the prefabricated rate increases. The impact changes in the energy footprint, carbon footprint, and terrestrial ecotoxicity, and are primarily determined by transport and are sensitive to transport distance and vehicle types.
Zn-P Co-Modified Hierarchical ZSM-5 Zeolites Directly Synthesized via Dry Gel Conversion for Enhanced Methanol to Aromatics Reaction
Authors: Wang Youhe , Li Zhihong , Dai Chang , Du Ningning , Li Tingting , Wang Risheng , Peng Peng , Sun Hongman
Published: November 2021

A unique method to prepare Zn-P co-modified hierarchical ZSM-5 zeolites was developed. The ZSM-5 zeolite was directly synthesized by a dry gel conversion without adding any templates or seeds. Afterwards, the hierarchical structure was endowed to the ZSM-5 zeolite by the sequential desilication-dealumination. Zn and P species were then introduced into the hierarchical ZSM-5 zeolites by the impregnation method and their activity in methanol to aromatics process was investigated. It was found that the Zn-P co-modified hierarchical ZSM-5 zeolites possessed more Zn-related Lewis acid sites, and the ratio of Zn(OH)+/ZnO was increased. The catalytic evaluation results revealed that the benzene, toluene and xylene (BTX) and aromatics selectivity were significantly improved from 20.59% and 29.41% of pristine ZSM-5 zeolite to 28.12% and 41.88% of Zn-P co-modified hierarchical counterpart (1.5Zn0.3P/HZSM-5), respectively. Owing to the introduced highly stable Zn-P co-modified hierarchical structures, the lifetime (conversion not less than 99%) of ZSM-5 zeolite during methanol to aromatics reaction was increased from 6 h to 18 h.
Congenital Adrenal Hyperplasia: Diagnostic Pitfalls in Prolonged Neonatal Jaundice
Authors: Rosli Nur Athirah , Mazapuspavina Md Yasin , Mohd Nor Noor Shafina
Published: November 2021

Congenital Adrenal Hyperplasia (CAH) is a genetic disorder that leads to cortisol deficiency. However, prolonged neonatal jaundice is a rare presentation of CAH. The pathophysiology of hyperbilirubinemia in CAH is still ill-defined. Plausible causes are related to the synthesis of bile, maturity of the liver and adrenal function. This case reported a neonate who presented with severe prolonged jaundice that lasted for more than a month. A short Synacthen test confirmed diagnosis of CAH. He was started on steroid replacement. He had regular follow-up under paediatric endocrinologist and primary care physician for long-term monitoring and overall health care. This case demonstrates the importance of recognizing the clinical and biochemical features of CAH for early detection and referral. Long-term follow-up and monitoring is necessary due to the risk of complications and side effects of medications. This is the first case of CAH presented with persistent hyperbilirubinemia to be reported from Malaysia. The case describes the difficult workup that has been encountered in the patient’s care and management.
Symbolic AI for XAI: Evaluating LFIT Inductive Programming for Explaining Biases in Machine Learning
Authors: Ortega Alfonso , Fierrez Julian , Morales Aythami , Wang Zilong , de la Cruz Marina , Alonso César Luis , Ribeiro Tony
Published: November 2021

Machine learning methods are growing in relevance for biometrics and personal information processing in domains such as forensics, e-health, recruitment, and e-learning. In these domains, white-box (human-readable) explanations of systems built on machine learning methods become crucial. Inductive logic programming (ILP) is a subfield of symbolic AI aimed to automatically learn declarative theories about the processing of data. Learning from interpretation transition (LFIT) is an ILP technique that can learn a propositional logic theory equivalent to a given black-box system (under certain conditions). The present work takes a first step to a general methodology to incorporate accurate declarative explanations to classic machine learning by checking the viability of LFIT in a specific AI application scenario: fair recruitment based on an automatic tool generated with machine learning methods for ranking Curricula Vitae that incorporates soft biometric information (gender and ethnicity). We show the expressiveness of LFIT for this specific problem and propose a scheme that can be applicable to other domains. In order to check the ability to cope with other domains no matter the machine learning paradigm used, we have done a preliminary test of the expressiveness of LFIT, feeding it with a real dataset about adult incomes taken from the US census, in which we consider the income level as a function of the rest of attributes to verify if LFIT can provide logical theory to support and explain to what extent higher incomes are biased by gender and ethnicity.
Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival
Authors: Li Wan-Shan , Chen Chih-I , Chen Hsin-Pao , Liu Kuang-Wen , Tsai Chia-Jen , Yang Ching-Chieh
Published: November 2021

Data mining of a public transcriptomic rectal cancer dataset (GSE35452) from the Gene Expression Omnibus, National Center for Biotechnology Information identified the melanophilin (MLPH) gene as the most significant intracellular protein transport-related gene (GO:0006886) associated with a poor response to preoperative chemoradiation. An MLPH immunostain was performed on biopsy specimens from 172 rectal cancer patients receiving preoperative chemoradiation; samples were divided into high- and low-expression groups by H-scores. Subsequently, the correlations between MLPH expression and clinicopathologic features, tumor regression grade, disease-specific survival (DSS), local recurrence-free survival (LRFS), and metastasis-free survival (MeFS) were analyzed. MLPH expression was significantly associated with CEA level (p = 0.001), pre-treatment tumor status (p = 0.022), post-treatment tumor status (p < 0.001), post-treatment nodal status (p < 0.001), vascular invasion (p = 0.028), and tumor regression grade (p < 0.001). After uni- and multi-variable analysis of five-year survival, MLPH expression was still associated with lower DSS (hazard ratio (HR), 10.110; 95% confidence interval (CI), 2.178–46.920; p = 0.003) and MeFS (HR, 5.621; 95% CI, 1.762–17.931; p = 0.004). In conclusion, identifying MLPH expression could help to predict the response to chemoradiation and survival, and aid in personal therapeutic modification.
Assessment of Operator Reliability in Ultrasound of the Median and Ulnar Nerve Using Bland-Altman Analysis
Authors: Philipps Jörg , Mork Hannah , Katz Maria , Knaup Mark , Beyer Kira , Spies Kristina , Corbach Johannes , Schellinger Peter D.
Published: November 2021

Currently, there is no standardized method to evaluate operator reliability in nerve ultrasound. A short prospective protocol using Bland–Altman analysis was developed to assess the level of agreement between operators with different expertise levels. A control rater without experience in nerve ultrasound, three novices after two months of training, an experienced rater with two years of experience, and a reference rater performed blinded ultrasound examinations of the left median and ulnar nerve in 42 nerve sites in healthy volunteers. The precision of Bland–Altman agreement analysis was tested using the Preiss–Fisher procedure. Intraclass correlation coefficients (ICC), coefficients of variation, and Bland–Altman limits of agreement were calculated. The sample size calculation and Preiss–Fisher procedure showed a sufficient precision of Bland–Altman agreement analysis. Limits of agreement of all trained novices ranged from 2.0 to 2.9 mm2 and were within the test’s maximum tolerated difference. Ninety-five percent confidence intervals of limits of agreement revealed a higher precision in the experienced rater’s measurements. Operator reliability in nerve ultrasound of the median and ulnar nerve arm nerves can be evaluated with a short prospective controlled protocol using Bland–Altman statistics, allowing a clear distinction between an untrained rater, trained novices after two months of training, and an experienced rater.
Siloranes–Suitability of a Novel Adhesive for Orthodontic Bracket Bonding
Authors: Brauchli Lorenz , Steineck Markus
Published: November 2021

Recently, an epoxy-based resin-Filtek Silorane-has been proposed for restorative fillings. It was the aim of the investigation to evaluate the suitability of this novel resin for orthodontic bracket bonding on unground enamel. Shear bond strength was measured for two adhesives-Filtek Silorane, Transbond XT-in combination with steel, ceramic and polymer brackets. For Filtek Silorane etching was performed with the Silorane self-etching primer, as well as phosphoric acid. The Transbond XT samples were etched with phosphoric acid only and served as the control group. All samples were thermo-cycled (1000×, 5–55 °C). Shear testing was carried out with an Instron 3344. In addition, ARI scores were evaluated. The Shear bond strength showed a weak adhesion of Filtek Silorane to unprepared enamel, either with the self-etching primer or the conventional etching (0.87–4.28 MPa). The Shear bond strength of the control group was significantly higher (7.6–16.5 MPa). The ARI scores showed a clear failure at the enamel-adhesive interface for all Filtek Silorane samples. For the combination of Transbond XT and different brackets the failure was found at the adhesive–bracket interface. The novel epoxy-based resin Filtek Silorane is not appropriate for bracket bonding to unprepared enamel.
Pedagogical Models to Implement Effective STEM Research Experience Programs in High School Students
Authors: Ahmad Zubair , Ammar Mohammad , Al-Thani Noora J.
Published: November 2021

High school research experience programs (HSREPs) provide opportunities for true science education and expose students to scientific investigations in laboratory settings. Various HSREPs models have been practiced to shape students’ research understandings; however, a systematic comparison of the success, challenges, and opportunities of these HSREPs has not been gauged. This article compares the effectiveness of such science, technology, engineering, and mathematics (STEM) based HSREP models reported in the last two decades. We shortlisted seventeen studies on the most effective HSREPs and identified the characteristics of these reports. Results show that student research experiences vary depending on the structure of the model used and the nature of the laboratory setting to which students are exposed. However, there is a dire need to integrate more collaborative and customized research practices to accommodate more students in HSREPs. Additionally, intensive support, mentoring, and coaching are essential to provide students a comprehensive understanding to excel in their research career pathway. Finally, there is a desperate need for further studies to develop the frameworks that can help the smooth transition of high school students into research-oriented university programs.
Effects of an Interdisciplinary Course on Pre-Service Primary Teachers’ Content Knowledge and Academic Self-Concepts in Science and Technology–A Quantitative Longitudinal Study
Authors: Beudels Melanie Marita , Damerau Karsten , Preisfeld Angelika
Published: November 2021

Primary school teachers need adequate professional knowledge and motivational orientations to qualify scientifically and technologically literate students. Previous studies have focused on the impact of coursework on (pre-service) primary teachers’ content knowledge, rather than on the development of academic self-concepts. In addition, the influence of the course format and the major field of study has not been investigated much to this date. Thus, this study examines the effects of an interdisciplinary course on pre-service primary teachers’ content knowledge and academic self-concepts in science and technology using a quasi-experimental, quantitative, pre-post-follow-up design (n = 202). Whilst no significant changes in knowledge were revealed for the baseline group not participating in the course, significant short-term and long-term cognitive gains were found for the experimental group. Biology-, chemistry-, physics- and technology-related self-concepts increased significantly when participating in the course. The results also indicate that the course format and major field of study can have an impact on the development of pre-service teachers’ professional knowledge. Regarding the development of academic self-concepts in the experimental group, it can be assumed that both the weekly and block course format are beneficial for heterogeneous learner groups consisting of pre-service teachers with different major fields of study.
Reliability Aware Multiple Path Installation in Software-Defined Networking
Authors: Raza Syed Mohsan , Ahvar Shohreh , Amin Rashid , Hussain Mudassar
Published: November 2021

Link failures frequently occur in communication networks, which negatively impacts network services delivery. Compared to traditional distributed networks, Software-Defined Networking (SDN) provides numerous benefits for link robustness to avoid services unavailability. To cope with link failures, the existing SDN approaches compute multiple paths and install corresponding flow rules at network switches without considering the reliability value of the primary computed path. This increases computation time, traffic overhead and end-to-end packets delay. This paper proposes a new approach called Reliability Aware Multiple Path Flow Rule (RAF) that calculates links reliability and installs minimum flow rules for multiple paths based on the reliability value of the primary path. RAF has been simulated, evaluated and compared with the existing approaches. The simulation results show that RAF performs better than the existing approaches in terms of computation overhead at the controller and reduces end-to-end packet delay and traffic overhead for flow rules installation.
Effect of Steam and Smoke Cooking Processes on Web-Foot Octopus (Amphioctopus sp.) Home Meal Replacement Product
Authors: Negara Bertoka Fajar Surya Perwira , Gong Hee-Jin , Lee Mi-Jeong , Choi Jae-Suk
Published: November 2021

In Korea, the web-foot octopus (Amphioctopus sp.) is commonly consumed as jjukkumi bokkeum, a spicy stir-fried octopus dish. Using steaming and smoking methods, we made jjukkumi bokkeum home meal replacement (HMR) products. The response surface methodology (RSM) was employed to optimize the steam and smoke processes. Quick freezing was applied to freeze the test product at −35 °C. Then, the physicochemical, biological, nutritional characteristics, and shelf-life of the test HMR products were evaluated. The optimal conditions for steaming and smoking were 95 °C for 2 min and 70 °C for 11 min, respectively. The pH, volatile basic nitrogen content, and thiobarbituric acid-reactive substances content decreased after steaming and smoking, indicating that these processes maintained these parameters well. Sensory evaluation revealed that there were no changes in these characteristics after freezing and reheating. Further, the test HMR products contained the daily nutritional requirements of macro and micronutrients, as well as amino acids and fatty acids. The shelf-life of the HMR products was estimated to be 15 months. The findings of this study indicate that the application of steam and smoke processes to produce a jjukkumi bokkeum HMR product results in a high-quality product with a long shelf-life.
Micropulse Transscleral Cyclophotocoagulation as Primary Surgical Treatment for Primary Open Angle Glaucoma in Taiwan during the COVID-19 Pandemic
Authors: Chang Hsiao-Ling , Chao Shih-Chun , Lee Ming-Tsung , Lin Hung-Yu
Published: November 2021

Glaucoma is the leading cause of irreversible blindness worldwide, with primary open angle glaucoma (POAG) accounting for the greatest number of total glaucoma cases. This study aimed to evaluate the efficacy and safety of micropulse transscleral cyclophotocoagulation (MP-TSCPC) as a primary procedure in POAG during the COVID-19 pandemic. We retrospectively analyzed 60 eyes of 52 patients, who were diagnosed with mild-to-end-stage POAG without previous glaucoma surgery and received MP-TSCPC between 1 January 2020 and 31 August 2020. The mean preoperative intraocular pressure (IOP) significantly decreased from 27.8 mm Hg to 19.8, 20.1, 20.3, 20.4, and 20.2 mm Hg at 1, 3, 6, 9, and 12 months, respectively (all p < 0.05). The mean number of IOP-lowering medications used significantly decreased from 3.3 at the baseline to 1.6, 1.8, 1.8, 1.9, and 1.9 at 1, 3, 6, 9, and 12 months, respectively (all p < 0.001). Total withdrawal of antiglaucoma medications was fulfilled in five patients. The main outcome was achieved in 81.7% at postoperative month 12. The most common adverse effect was transient mydriasis (28.3%). No major complications were encountered. MP-TSCPC seems to be an effective and safe treatment to reduce IOP and the medication burden with minimal vision-threatening complications in mild-to-end-stage POAG patients without previous glaucoma surgery.
Retrospective Analysis of Antimicrobial Susceptibility of Uropathogens Isolated from Pediatric Patients in Tertiary Hospital at Al-Baha Region, Saudi Arabia
Authors: Alzahrani Mohammed Abdullah , Sadoma Heba Hassan Mohamed , Mathew Sowmya , Alghamdi Saleh , Malik Jonaid Ahmad , Anwar Sirajudheen
Published: November 2021

Introduction: Prompt diagnosis and initiation of treatment are essential in preventing long-term renal scarring. However, increasing antibiotic resistance may delay the initiation of appropriate therapy. Methodology: A retrospective chart review was performed for patients admitted to the pediatric department with urinary tract infection (UTI) diagnosis in a large tertiary care hospital in Al Baha, Saudi Arabia, from May 2017 to April 2018. The study included children of both sexes under the age of 14 years. Results: Out of 118 urinary bacterial samples, Escherichia coli was the main etiologic agent in the community- and hospital-acquired infections. The infection rate was higher in girls (68.64%) than in boys (31.36%). The commonest isolates were Escherichia coli (44.07%), extended-spectrum beta-lactamase-producing Escherichia coli (11.86%), Klebsiella pneumoniae (9.32%), Enterococcus faecalis (7.63%), methicillin-resistant Staphylococcus epidermidis (4.24%), and coagulase-negative Staphylococci (3.39%). The current study demonstrates that nitrofurantoin (19%) was the most commonly prescribed medication in the inpatient and outpatient departments, followed by trimethoprim/sulfamethoxazole (16%), amoxicillin/clavulanic acid (15%), cefuroxime (10%), azithromycin (8%), ceftriaxone (7%), and ciprofloxacin (4%), while amikacin, amoxicillin, ampicillin, cefepime, imipenem, phenoxymethylpenicillin were prescribed less commonly due to the high resistance rate. Conclusion: The microbial culture and sensitivity of the isolates from urine samples should be routine before starting antimicrobial therapy. Current knowledge of the antibiotic susceptibility patterns of uropathogens in specific geographical locations is essential for choosing an appropriate empirical antimicrobial treatment rather than reliance on recommended guidelines.
A Comprehensive Analysis of Hurricane Damage across the U.S. Gulf and Atlantic Coasts Using Geospatial Big Data
Authors: Park Gainbi
Published: November 2021

(1) Background: Hurricane events are expected to increase as a consequence of climate change, increasing their intensity and severity. Destructive hurricane activities pose the greatest threat to coastal communities along the U.S. Gulf of Mexico and Atlantic Coasts in the conterminous United States. This study investigated the historical extent of hurricane-related damage, identifying the most at-risk areas of hurricanes using geospatial big data. As a supplement to analysis, this study further examined the overall population trend within the hurricane at-risk zones. (2) Methods: The Sea, Lake, and Overland Surges from Hurricanes (SLOSH) model and the HURRECON model were used to estimate the geographical extent of the storm surge inundation and wind damage of historical hurricanes from 1950 to 2018. The modeled results from every hurricane were then aggregated to a single unified spatial surface to examine the generalized hurricane patterns across the affected coastal counties. Based on this singular spatial boundary coupled with demographic datasets, zonal analysis was applied to explore the historical population at risk. (3) Results: A total of 775 counties were found to comprise the “hurricane-prone coastal counties” that have experienced at least one instance of hurricane damage over the study period. The overall demographic trends within the hurricane-prone coastal counties revealed that the coastal populations are growing at a faster pace than the national average, and this growth puts more people at greater risk of hurricane hazards. (4) Conclusions: This study is the first comprehensive investigation of hurricane vulnerability encompassing the Atlantic and Gulf Coasts stretching from Texas to Maine over a long span of time. The findings from this study can serve as a basis for understanding the exposure of at-risk populations to hurricane-related damage within the coastal counties at a national scale.
Elbow Stiffness Imaging: A Practical Diagnostic and Pretherapeutic Approach
Authors: Lombard Charles , Teixeira Pedro , Germain Edouard , Dodin Gauthier , Louis Mathias , Blum Alain , Gillet Romain
Published: November 2021

Loss of elbow motion can lead to disability in everyday gestures, recreational activities, and work. Unfortunately, the elbow joint is particularly prone to stiffness because of its complex anatomy and biomechanics. The etiology of elbow stiffness is varied and must be diagnosed accurately in order to allow optimal treatment, which may be challenging for surgeons and physiotherapists. Its treatment can be either conservative, arthroscopic or surgical, with a trend for arthroscopic procedures when conservative treatment fails. There is no consensus on the optimal imaging workup for elbow joint stiffness, which may have an impact on patient management. This article reviews the current classification systems of elbow stiffness and the various imaging techniques used for diagnosis. Report checklists and clarifications on the role of each imaging method, as well as the imaging findings of normal and stiff elbows, are presented, leading to a proposed diagnostic algorithm. The main concern in imaging is to determine the cause of elbow stiffness, as many concomitant abnormalities might be present depending on the clinical scenario.
The Performance of Dual-Task Tests Can Be a Combined Neuro-Psychological and Motor Marker of Mild Cognitive Impairment, Depression and Dementia in Geriatric Patients—A Cross-Sectional Study
Authors: Kasiukiewicz Agnieszka , Magnuszewski Lukasz , Swietek Marta , Wojszel Zyta Beata
Published: November 2021

The study aims to assess the performance of dual-task tests in the geriatric population and their association with the cognitive status of the patients. Methods: Patients admitted to the Department of Geriatrics, Hospital of the Ministry of Interior and Administration on Bialystok, Poland, in 2019 and 2020 were enrolled in the study. Data on the patients’ clinical, functional, and cognitive status were collected based on the comprehensive geriatric assessment. Dual-task tests included Timed Up and Go (TUG) test while counting backward (CB7), enumerating animals (EA), and holding a cup (TUG M). Results: 250 patients were included in the study, with a median age of 81.5 years (IQR 76–86) and most above 75 years of age (80.8%). Only 29 (11.6%) of study participants had no cognitive or mood disorders. Depression was diagnosed in 30.4%, MCI in 12%, and dementia in 38.4% of cases with median Mini-Mental Score Evaluation (MMSE) 17 (12–20) points. Dual-task TUG CB7 results did not differ between cognitive conditions of patients. TUG EA differed between healthy controls and other cognitive groups and TUG between healthy controls and depression and dementia, but not mild cognitive impairment (MCI). The performance of all dual-task tests differed in patients with and without dementia. Ability to finish TUG CB7 was low even in the group without dementia. There were statistically significant differences in median scores of MMSE and Clock Drawing Test (CDT) between patients who were able or not to finish single and dual-task gait tests. Conclusion: Dual-task test results and the performance of these tasks can differentiate patients with depression, MCI and dementia compared to healthy controls in the geriatric population.