Uveitis manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study
Authors: Biedermann Luc , Renz Laura , Fournier Nicolas , Rossel Jean-Benoît , Butter Matthias , Bluemel Sena , Vavricka Stephan R. , Rogler Gerhard , Scharl Michael , Anderegg Claudia , Bauerfeind Peter , Beglinger Christoph , Begré Stefan , Belli Dominique , Bengoa José M. , Biedermann Luc , Bigler Beat , Binek Janek , Blattmann Mirjam , Boehm Stephan , Borovicka Jan , Braegger Christian P. , Brunner Nora , Bühr Patrick , Burnand Bernard , Burri Emanuel , Buyse Sophie , Cremer Matthias , Criblez Dominique H. , Saussure Philippe de , Degen Lukas , Delarive Joakim , Doerig Christopher , Dora Barbara , Dorta Gian , Egger Mara , Ehmann Tobias , El-Wafa Ali , Engelmann Matthias , Ezri Jessica , Felley Christian , Fliegner Markus , Fournier Nicolas , Fraga Montserrat , Frei Pascal , Frei Remus , Fried Michael , Froehlich Florian , Funk Christian , Ivano Furlano Raoul , Gallot-Lavallée Suzanne , Geyer Martin , Girardin Marc , Golay Delphine , Grandinetti Tanja , Gysi Beat , Haack Horst , Haarer Johannes , Helbling Beat , Hengstler Peter , Herzog Denise , Hess Cyrill , Heyland Klaas , Hinterleitner Thomas , Hiroz Philippe , Hirschi Claudia , Hruz Petr , Iwata Rika , Jost Res , Juillerat Pascal , Kessler Brondolo Vera , Knellwolf Christina , Knoblauch Christoph , Köhler Henrik , Koller Rebekka , Krieger-Grübel Claudia , Kullak-Ublick Gerd , Künzler Patrizia , Landolt Markus , Lange Rupprecht , Serge Lehmann Frank , Macpherson Andrew , Maerten Philippe , Maillard Michel H. , Manser Christine , Manz Michael , Marbet Urs , Marx George , Matter Christoph , McLin Valérie , Meier Rémy , Mendanova Martina , Meyenberger Christa , Michetti Pierre , Misselwitz Benjamin , Moradpour Darius , Morell Bernhard , Mosler Patrick , Mottet Christian , Müller Christoph , Müller Pascal , Müllhaupt Beat , Münger-Beyeler Claudia , Musso Leilla , Nagy Andreas , Neagu Michaela , Nichita Cristina , Niess Jan , Noël Natacha , Nydegger Andreas , Obialo Nicole , Oneta Carl , Oropesa Cassandra , Peter Ueli , Peternac Daniel , Marie Petit Laetitia , Piccoli-Gfeller Franziska , Beatrice Pilz Julia , Pittet Valérie , Raschle Nadia , Rentsch Ronald , Restellini Sophie , Richterich Jean-Pierre , Rihs Sylvia , Alain Ritz Marc , Roduit Jocelyn , Rogler Daniela , Rogler Gerhard , Rossel Jean-Benoît , Sagmeister Markus , Saner Gaby , Sauter Bernhard , Sawatzki Mikael , Schäppi Michela , Scharl Michael , Schelling Martin , Schibli Susanne , Schlauri Hugo , Schmid Uebelhart Sybille , Schnegg Jean-François , Schoepfer Alain , Seibold Frank , Seirafi Mariam , Semadeni Gian-Marco , Semela David , Senning Arne , Sidler Marc , Sokollik Christiane , Spalinger Johannes , Spangenberger Holger , Stadler Philippe , Steuerwald Michael , Straumann Alex , Straumann-Funk Bigna , Sulz Michael , Thorens Joël , Tiedemann Sarah , Tutuian Radu , Vavricka Stephan , Viani Francesco , Vögtlin Jürg , Von Känel Roland , Vonlaufen Alain , Vouillamoz Dominique , Vulliamy Rachel , Wermuth Jürg , Werner Helene , Wiesel Paul , Wiest Reiner , Wylie Tina , Zeitz Jonas , Zimmermann Dorothee 
Published: August 2019

Background:

The knowledge about risk factors for the onset of uveitis manifestations in patients with inflammatory bowel disease (IBD) is still limited. Here, we aimed to provide an overview of the clinical factors associated with the onset of uveitis in the Swiss IBD Cohort Study (SIBDCS).

Methods:

We included epidemiological and clinical data from 1840 patients with Crohn’s disease (CD) and 1426 patients with ulcerative colitis (UC) followed up in the SIBDCS between 2006 and 2018. Associations between disease characteristics and uveitis were assessed in univariate and multivariate analyses.

Results:

Overall, we identified 285 patients with uveitis. Uveitis was more frequent in patients with CD (11.1%; 205 of 1635) than UC (5.6%; 80 of 1346; odds ratio 2.11, p < 0.001). The occurrence of uveitis manifestations in patients with UC and CD was significantly associated with the onset of other extraintestinal manifestations, also in multivariate analyses. The onset of uveitis was associated with the hallmark features of severe disease in both CD and UC, including a higher clinical disease activity index and the use of immunomodulators or calcineurin inhibitors. In CD, uveitis was more frequent in females and showed a positive correlation with a positive family history of IBD.

Conclusions:

Our data demonstrate that uveitis in IBD occurs more often in CD as well as in women and is associated with a more severe disease course. This might guide physicians’ awareness in at-risk patients to the presence of uveitis extraintestinal manifestations and help to improve patient care.