bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Renin-Angiotensin System Inhibitors on the Comparative Nephrotoxicity of NSAIDs and Opioids during Hospitalization
Authors: Miano Todd A. , Shashaty Michael G. S. , Yang Wei , Brown Jeremiah R. , Zuppa Athena , Hennessy Sean
Published: April 2020

Background

Nonsteroidal anti-inflammatory drugs (NSAIDS) are increasingly important alternatives to opioids for analgesia during hospitalization as health systems implement opioid-minimization initiatives. Increasing NSAID use may increase AKI rates, particularly in patients with predisposing risk factors. Inconclusive data in outpatient populations suggests that NSAID nephrotoxicity is magnified by renin-angiotensin system inhibitors (RAS-I). No studies have tested this in hospitalized patients.

Methods

Retrospective, active-comparator cohort study of patients admitted to four hospitals in Philadelphia, Pennsylvania. To minimize confounding by indication, NSAIDs were compared to oxycodone, and RAS-I were compared to amlodipine. We tested synergistic NSAID+RAS-I nephrotoxicity by comparing the difference in AKI rate between NSAID versus oxycodone in patients treated with RAS-I to the difference in AKI rate between NSAID versus oxycodone in patients treated with amlodipine. In a secondary analysis, we restricted the cohort to patients with baseline diuretic treatment. AKI rates were adjusted for 71 baseline characteristics with inverse probability of treatment-weighted Poisson regression.

Results

The analysis included 25,571 patients who received a median of 2.4 days of analgesia. The overall AKI rate was 23.6 per 1000 days. The rate difference (RD) for NSAID versus oxycodone in patients treated with amlodipine was 4.1 per 1000 days (95% CI, −2.8 to 11.1), and the rate difference for NSAID versus oxycodone in patients treated with RAS-I was 5.9 per 1000 days (95% CI, 1.9 to 10.1), resulting in a nonsignificant interaction estimate: 1.85 excess AKI events per 1000 days (95% CI, −6.23 to 9.92). Analysis in patients treated with diuretics produced a higher, albeit nonsignificant, interaction estimate: 9.89 excess AKI events per 1000 days (95% CI, −5.04 to 24.83).

Conclusions

Synergistic nephrotoxicity was not observed with short-term NSAID+RAS-I treatment in the absence of concomitant diuretics, suggesting that RAS-I treatment may not be a reason to choose opioids in lieu of NSAIDs in this population. Synergistic nephrotoxicity cannot be ruled out in patients treated with diuretics.
Continental crust in the Davis Strait: new evidence from seabed sampling
Authors: Dalhoff Finn , Larsen Lotte M. , Ineson Jon R. , Stouge Svend , Bojesen-Koefoed Jørgen A. , Lassen Susanne , Kuijpers Antoon , Rasmussen Jan A. , Nøhr-Hansen Henrik
Published: April 2020

Although the structural framework of the subsurface offshore West Greenland has been well documented based on comprehensive seismic analysis (cf. Dalhoff et al. 2003), the stratigraphy of the region is less well known. The oldest documented sedimentary rocks drilled offshore West Greenland are Santonian sandstones reached at TD in the 6354/4-1 well (Fig. 1) although reworked palynomorphs of Carboniferous, Triassic and Jurassic (Kimmeridgian) age have been reported from a number of wells in the region. In order to obtain better constraints on the pre-Upper Cretaceous stratigraphy, a preliminary screening was undertaken to identify inversion structures and erosional canyons where such deeper stratigraphic levels crop out at the seabed (Nielsen et al. 2001). Sea-floor sampling at selected sites between 62° and 67°N (Fig. 1) was undertaken during the summers of 2003 and 2004. Other objectives of these cruises were to seek direct evidence of active petroleum systems, to establish further constraints on tectonic and stratigraphic models, and to obtain a better understanding of the Neogene and Pleistocene history of the region (Dalhoff et al. 2005). The most promising seabed features identified by Nielsen et al. (2001) were investigated in more detail using a wide range of techniques in order to optimise sampling positions. In 2003, these techniques included echo sounder, side-scan sonar, single-channel seismic and video inspection before sampling either by dredge, gravity corer, or by video-controlled grab. In 2004, comprehensive data acquisition with a deep-water sparker system was undertaken before sampling by dredge or gravity corer, supplemented by grab samples at selected stations.
A lead isotope study of an Archaean gold prospect in the Attu region, Nagssugtoqidian orogen, West Greenland
Authors: Stendal Henrik , Frei Robert , Møller Stensgaard Bo
Published: April 2020

This paper presents a lead isotope investigation of a gold prospect south of the village Attu in the northern part of the Nagssugtoqidian orogen in central West Greenland. The Attu gold prospect is a replacement gold occurrence, related to a shear/mylonite zone along a contact between orthogneiss and amphibolite within the Nagssugtoqidian orogenic belt. The mineral occurrence is small, less than 0.5 m wide, and can be followed along strike for several hundred metres. The mineral assemblage is pyrite, chalcopyrite, magnetite and gold. The host rocks to the gold prospect are granulite facies ‘brown gneisses’ and amphibolites. Pb-isotopic data on magnetite from the host rocks yield an isochron in a 207Pb/204Pb vs. 206Pb/204Pb diagram, giving a date of 3162 ± 43 Ma (MSWD = 0.5). This date is interpreted to represent the age of the rocks in question, and is older than dates obtained from rocks elsewhere within the Nagssugtoqidian orogen. Pb-isotopic data on cataclastic magnetite from the shear zone lie close to this isochron, indicating a similar origin. The Pb-isotopic compositions of the ore minerals are similar to those previously obtained from the close-by ~2650 Ma Rifkol granite, and suggest a genetic link between the emplacement of this granite and the formation of the ore minerals in the shear/mylonite zone. Consequently, the age of the gold mineralisation is interpreted to be late Archaean.
207Pb-206Pb dating of magnetite, monazite and allanite in the central and northern Nagssugtoqidian orogen, West Greenland
Authors: Stendal Henrik , Secher Karsten , Frei Robert
Published: April 2020

Pb-isotopic data for magnetite from amphibolites in the Nagssugtoqidian orogen, central West Greenland, have been used to trace their source characteristics and the timing of metamorphism. Analyses of the magnetite define a Pb-Pb isochron age of 1726 ± 7 Ma. The magnetite is metamorphic in origin, and the 1726 Ma age is interpreted as a cooling age through the closing temperature of magnetite at ~600°C. Some of the amphibolites in this study come from the Naternaq supracrustal rocks in the northern Nagssugtoqidian orogen, which host the Naternaq sulphide deposit and may be part of the Nordre Strømfjord supracrustal suite, which was deposited at around 1950 Ma ago. Pb-isotopic signatures of magnetite from the Arfersiorfik quartz diorite in the central Nagssugtoqidian orogen are compatible with published whole-rock Pb-isotopic data from this suite; previous work has shown that it is a product of subduction-related calc-alkaline magmatism between 1920 and 1870 Ma. Intrusion of pegmatites occurred at around 1800 Ma in both the central and the northern parts of the orogen. Pegmatite ages have been determined by Pb stepwise leaching analyses of allanite and monazite, and source characteristics of Pb point to an origin of the pegmatites by melting of the surrounding late Archaean and Palaeoproterozoic country rocks. Hydrothermal activity took place after pegmatite emplacement and continued below the closure temperature of magnetite at 1800– 1650 Ma. Because of the relatively inert and refractory nature of magnetite, Pb-isotopic measurements from this mineral may be of help to understand the metamorphic evolution of geologically complex terrains.
Towards a national 3D geological model of Denmark
Authors: Sandersen Peter B.E. , Vangkilde-Pedersen Thomas , Jørgensen Flemming , Thomsen Richard , Tulstrup Jørgen , Fredericia Johnny
Published: April 2020

As part of its strategy, the Geological Survey of Denmark and Greenland (GEUS) is to develop a national, digital 3D geological model of Denmark that can act as a publicly accessible database representing the current, overall interpretation of the subsurface geology. A national model should be under constant development, focusing on meeting the current demands from society. The constant improvements in computer capacity and software capabilities have led to a growing demand for advanced geological models and 3D maps that meet the current technical standards (Berg et al. 2011). As a consequence, the users expect solutions to still more complicated and sophisticated problems related to the subsurface. GEUS has a long tradition of making 2D maps of subsurface layer boundaries and near-surface geology (Fredericia & Gravesen 2014), but in the change from 2D to 3D and when combining data in new ways, new geological knowledge is gained and new challenges of both technical and organisational character will arise. The purpose of this paper is to present the strategy for the national 3D geological model of Denmark and the planned activities for the years ahead. The paper will also reflect on some of the challenges related to making and maintaining a nationwide 3D model. Initially, the model will only include the Danish onshore areas, with the Danish offshore areas and Greenland to be added later using a similar general setup.
Pre-Quaternary rocks and sediments with a high level of radioactivity in Denmark
Authors: Gravesen Peter , Roll Jakobsen Peter
Published: April 2020

The pre-Quaternary sediments and rocks in Denmark generally have a low content of radioactive minerals and elements. Uranium, thorium and radium are built into mineral structures or are, for example, adsorbed on the surface of clay minerals, Fe-minerals or organic material. Radon (222Rn) is a radioactive noble insoluble gas with a half-life of 3.8 days. It belongs to the uranium (238U) decay chain where radon is formed from radium (226Ra). When Rn is formed by radioactive decay from Ra, the emanation process sends part of the radon produced into the pore spaces of rocks and soils. From here, the radon can enter and accumulate in buildings. The source of the radioactive materials in Danish sediments and rocks is primarily from weathered Precambrian crystalline rocks from Norway, Sweden, Finland and the Danish island of Bornholm. Physical and chemical weathering disintegrates these rocks and rivers transport the material into the Danish–Norwegian and Danish–Polish sedimentary basins.
Types of formation water and produced water in Danish oil- and gasfields: implications for enhanced oil recovery by injection of ‘smart’ water
Authors: Schovsbo Niels H. , Holmslykke Hanne D. , Kjøller Claus , Hedegaard Kathrine , Kristensen Lars , Thomsen Erik , Esbensen Kim H.
Published: April 2020

Injection of chemically tuned, ‘smart’ water in oil reservoirs may increase both oil recovery rates and the total recovery (e.g. Morrow & Buckley 2011; Austad 2013; Zeinijahromi et al. 2015). This kind of water management has gained increased importance in the Danish North Sea reservoirs due to decreasing sweep efficiency in maturing oilfields. Knowledge about the compatibility of the injected water with local formation waters is, however, a prerequisite for successful implementation. Here, we present a regional overview of formation waters from oil reservoirs in the Danish North Sea, which comprise three main types of formation brine, and one type of modified seawater related to extensive water flooding. The water types show a distinct geographical distribution, which reflects original connate waters that are modified by saline brine being either depleted or enriched in SO42–.
Some Subordination and Superordination Results for Normalized Analytic Functions Defined by Convolution Structure Associated with Wanas Differential Operator
Authors: Wanas Abbas Kareem , Alina Alb Lupas
Published: April 2020

The purpose of this paper is to establish some subordination and superordination results involving Hadamard product for certain normalized analytic functions associated with Wanas differential operator defined in the open unit disk and obtain sandwich results. Our results extend corresponding previously known results.
STUDY OF THE STRUCTURE AND PHASE COMPOSITION OF THE OXIDE FILM ON THE SURFACE OF A LAYERED COATING OF THE Al-Ni SYSTEM
Authors: Shmorgun V. G. , Bogdanov A. I. , Kulevich V. P. , Evchits R. D.
Published: April 2020

This work is aimed to the study of the structure and phase composition of the oxide film formed on the surface of the layered coating of the Al-Ni system during high-temperature heating. It was experimentally established that at the initial stages of heat treatment, as a result of the interaction of the Al-Ni system layered coating with atmospheric oxygen, separate sections of Al2O3 oxide are formed on its surface, which are agglomerates of plate crystals of α-modification of nanometer thickness, which increase and grow together with increasing exposure time continuous protective oxide film. An increase in the heating temperature leads to an intensification of oxidation processes and the formation of a complex oxide film of AlO and spinel NiAlO.
STUDY OF DIFFUSION PROCESSES IN BIMETAL STEEL 20 - STAINLESS STEEL 50Cr15Мo2V AFTER EXPLOSION WELDING AND THERMAL TREATMENT
Authors: Trudov A. F. , Arisova V. N. , Gurevich L. M. , Birshbaeva A. E. , Kharlamov V. O.
Published: April 2020

The results of studying the diffusion of alloying elements of stainless steel 50Cr15Мo2V of a two-layer composite material at the interface with carbon steel 20 after explosion welding and subsequent heat treatment are presented. The absence of significant diffusion of chromium from alloyed to low-carbon steel has been established.
RESEARCH OF THE CRYSTALLINE STRUCTURE OF POLYMERIC COMPOSITE MIXTURES AFTER EXPLOSIVE PRESSING
Authors: Adamenko N. A. , Agafonova G. V. , Savin D. V. , Bogdanov A. I. , An D. A. , Kazurov A. V.
Published: April 2020

The method of X-ray diffraction analysis was used to study polymer composites based on thermoplastic polymers of ultra-high molecular weight polyethylene UHMWPE with β-sialon and polytetrafluoroethylene PTFE with aluminum oxide Al2O3 after static and explosive pressing. The studies were carried out with the aim of developing explosive pressing technology for polymer composite materials with enhanced strength and antifriction properties.
RESEARCH OF THE STRESS DISTRIBUTION IN THE HINGE ELEMENT OF THE LEADING RING OF A SPHERICAL TRANSFORMING MECHANISM
Authors: Popov A. V. , Rozhnov A. A. , Notov I. V.
Published: April 2020

The article presents a theoretical study of the stress distribution of the leading links of the spherical transforming mechanism. Diagrams of the stress-strain state and stress fields in the leading element of a spherical mechanism are presented. Methods for improving the reliability and load capacity of the hinge drive shaft with the leading ring of the spherical mechanism are proposed.
FAKTOR-FAKTOR YANG MEMPENGARUHI KUALITAS PENGUNGKAPAN INFORMASI TANGGUNG JAWAB SOSIAL PERUSAHAAN DAN DAMPAKNYA TERHADAP COST OF EQUITY
Authors: Paradita Ekapratna
Published: April 2020

Penelitian ini bertujuan untuk mengetahui pengaruh besaran perusahaan, profitabilitas, leverage, dan kualitas tata kelola perusahaan terhadap kualitas pengungkapan informasi tanggung jawab sosial perusahaan (CSR), serta dampak kualitas pengungkapan informasi tanggung jawab sosial perusahaan terhadap cost of equity. Populasi dalam penelitian ini adalah semua perusahaan yang mengikuti pemeringkatan IICG pada 2011-2016. Pengambilan sampel dilakukan dengan metode purposive sampling, dan menghasilkan sampel sebanyak 92 perusahaan. Pengumpulan data dilakukan dengan menganalisis laporan keuangan, laporan keberlanjutan dan laporan tahunan perusahaan dari situs web perusahaan sampel, situs web Bursa Efek Indonesia, dan majalah SWA Indonesia. Teknik analisis yang digunakan dalam penelitian ini adalah teknik analisis regresi berganda untuk mengukur pengaruh lebih dari satu variabel independen terhadap variabel dependen dan regresi sederhana. Hasil pengujian hipotesis dalam penelitian ini menunjukkan bahwa besaran perusahaan dan leverage tidak memengaruhi kualitas pengungkapan informasi tanggung jawab sosial perusahaan (CSR). Profitabilitas dan kualitas tata kelola perusahaan menunjukkan pengaruh positif yang signifikan terhadap kualitas pengungkapan informasi tanggung jawab sosial perusahaan (CSR). Hasil pengujian hipotesis juga menunjukkan bahwa kualitas pengungkapan informasi tanggung jawab sosial perusahaan (CSR) memiliki pengaruh negatif yang signifikan terhadap cost of equity.
PENGARUH KNOWLEDGE MANAGEMENT TERHADAP SUSTAINABLE LIVELIHOOD
Authors: Soepardy Ahmad Taufiq
Published: April 2020

Penelitian ini bertujuan untuk menguji dan menjelaskan pengaruh knowlegde management terhadap sustainable livelihood di Kelurahan Bungkutoko Kota Kendari. Populasi dalam penelitian ini adalah masyarakat dan stakeholder di Kelurahan Bungkutoko Kota Kendari. Teknik penarikan sampling adalah secara probability sampling dengan metode pengumpulan data melalui kuesioner, Focus Group Discussion (FGD) dan wawancara. Adapaun analisis data menggunakan analisis regresi linear sederhana melalui bantuan program SPSS versi 20.0 for windows. Responden yang terlibat antara lain aparat pemerintah kelurahan, tokoh masyarakat, kelompok-kelompok nelayan, kelompok wirausahawan, pelaku program pemberdayaan, kelompok wanita, kelompok peduli dan pemerhati. Hasil yang diperoleh adalah knowledge management memiliki pengaruh positif dan signifikan terhadap sustainable livelihood di Kelurahan Bungkutoko Kota Kendari. Hal ini menunjukkan bahwa tinggi rendahnya sustainable livelihood dipengaruhi oleh knowledge management. Semakin tinggi knowledge management para stakeholder yang ada di Kelurahan Bungkutoko Kota Kendari, maka akan semakin tinggi pula sustainable livelihood yang dicapai.
A Novel Texture Classification Method Based on Neutrosophic Truth
Authors: ALPASLAN Nuh
Published: April 2020

Texture analysis is one of the basic procedures used in solving problems in computer vision and image processing. In this study, we propose a new local binary pattern (LBP) method based on neutrosophic set. The proposed method is named as the NZ - LBP. In the proposed NZ - LBP method, the texture image is converted into a neutrosophic set and the texture image is expressed by truth membership set. The local binary pattern features are calculated, by using the neutrosophic truth set instead of the original input image. The neutrosophic membership sets are more resistant to noise than the original input image. The neutrosophic set suppresses noise components, so that edge information can be calculated more accurately. Thus, utilization of the neutrosophic truth set instead of the original image has provided more effective local binary pattern features. The proposed method is able to achieve high classification accuracy with low feature size, reasonable computational cost. Experimental results show that the proposed method increases the accuracy of the local binary pattern method to the classification by approximately 11% without increasing the feature dimension. The obtained results reveal that the proposed method is applicable for real-time applications.
Estimation of Permanent Magnet Synchronous Generator Performance with Artificial Neural Network Models
Authors: ÇETİN Onursal , DALCALI Adem , TEMURTAŞ Feyzullah
Published: April 2020

The interest in renewable energy sources has grown with the increase of environmental pollution and the decrease of fossil fuels. It is possible to provide energy supply security and diversity by using renewable energy sources. In this regard, wind energy, which is one of the renewable energy sources whose share in energy production increases day by day, emerges as a local and environmentally friendly solution. Many different types of generators are used in wind turbines and these have advantages and disadvantages according to each other. Permanent magnet synchronous generators (PMSG) are preferred because of their advantages such as high efficiency, high power density and being used directly in wind turbines without the need for gear system. In this study, the performance of the 2,5 kW PMSG, with a 14-pole surface placement, internal rotor, suitable for use in wind turbines, has been examined by changing the physical structure of the magnet. For this purpose, performance parameters such as total magnet consumption, efficiency, power loss have been successfully estimated using single and double hidden layered multi layer neural network (MLNN), elman neural network (ENN) and radial basis function neural network (RBFNN).
Serum Katalaz, Miyeloperoksidaz ve Paraoksonaz 1 Üzerine Bazı Bitki Ekstraktlarının In Vitro Etkisi
Authors: KİRMİT Adnan , IŞIK Mesut
Published: April 2020

Amaç: Fenolik içerik bakımından zengin olan doğal bitkilerin geleneksel ve tamamlayıcı tıpta tedavi amaçlı kullanılabileceği vurgusu yapılmaktadır. Bu amaçla Artemisia absinthium (pelin otu), Ferula communis (çakşır otu), Achillea millefolium (civanperçemi), Equisetum arvense (tarla atkuyruğu) ve Hypericum perforatum (sarı kantaron) su ektraklarının paraoksanaz 1 (PON1), miyeloperoksidaz (MPO) ve katalaz (CAT) enzim aktiviteleri ile serum total anti-oksidan seviye (TAS) ve total oksidan seviye (TOS) üzerine etkileri araştırılmıştır.Materyal ve metod: Her bir bitkinin su ekstraktı hazırlanmış olup, bu ekstraktlar serum numunelerine belli oranda eklenerek nihai konsantrasyon 60 µg/mL olarak uygulanmıştır. Hazırlanan bu ekstraktların serum parametreleri üzerine etkilerini araştırmak için TAS ve TOS parametreleri Erel, MPO aktivitesi Bradley, PON1 aktivitesi Eckerson, CAT aktivitesi Goth yöntemiyle ölçülmüştür. Reaktifler, Harran Üniversitesi Tıp Fakültesi Tıbbi Biyokimya Anabilim Dalı Laboratuvarında hazırlanmış ve analizler rutin Biyokimya Laboratuvarı otoanalizöründe (Architect C16000, Abbott) spekrofotometrik olarak çalışılmıştır.Bulgular: Kontrol değerleri CAT (23,233± 1,665 kU/L), MPO (103,483± 4,048 U/L), PON1 (24,833± 1,404 U/L), TAS (1,223± 0,080 mmol Troloks Eqv/L) ve TOS (6,350± 0,481 µmol H2O2 Eqv/L) kantitatif olarak saptanmıştır. Pelin otu, çakşır otu, civanperçemi ve sarı kantaron CAT, MPO ve PON1 enzimlerini inhibe etmiştir (p <0.05, p <0.01). Tarla atkuyruğu ise sadece MPO üzerine inhibisyon etkisi göstermiştir (p <0.01). Civanperçemi ve sarı kantaron TOS düzeyini düşürürken TAS düzeyini artırmıştır (p <0.05, p <0.01).Sonuç: Çakşır otu ve tarla atkuyruğu bitki ekstraktları in vitro olarak MPO üzerine inhibisyon etkisi gösterirken PON1 üzerine ise zayıf inhibisyon etkisi göstermiştir. Bu bitkilerin in vivo etkinliği ortaya konulabilirse ateroskleroz gibi hastalıklarda intravasküler lipit peroksidasyonu sonucu meydana gelen plak oluşumunu inhibe edebileceği ve vasküler fonksiyonları iyileştirebileceği söylenebilir. Anahtar Kelimeler: Tıbbi Bitki, Lipit peroksidasyonu, Paraoksanaz 1, Miyeloperoksidaz
Ses Kısıklığının Gözardı Edilen Nedeni: Larinks Tüberkülozu
Authors: HOCANLI İclal
Published: April 2020

Günümüzde dünya nüfusunun üçte birinin tüberküloz basili ile enfekte olduğu tahmin edilmektedir. Her yıl yaklaşık sekiz milyon yeni tüberküloz hastalığı tanısı konurken, hastalığa bağlı olarak yılda 2 milyon ölüm meydana gelmektedir. Larengeal tüberküloz, tüm tüberküloz olgularının %1’inden azını temsil eder. Hastaların büyük bir kısmında tüberküloz öyküsü ya da aktif tüberküloz enfeksiyonu vardır. Hastalarda ortaya çıkan ilk belirtiler ağrılı disfaji ve ses kısıklığı olmakla birlikte kilo kaybı ve gece terlemesi gibi sistemik semptomlar da görülebilir. Günümüzde antitüberküloz ilaçların yaygın olarak kullanılması ile larinks tüberkülozu insidansı azalmıştır. Bu yazımızda, iki yıldır ses kısıklığı olan ve son dönemlerde nefes darlığı, kilo kaybı gibi şikayetlerin de ortaya çıkmasıyla larinks ve akciğer tüberkülozu tanısı konulan bir olguyu sunmayı amaçladık.
Hipertiroidi Hastalarında Tedavi Öncesi ve Sonrası Trombosit/Lenfosit ve Nötrofil/Lenfosit Oranlarının Değerlendirilmesi
Authors: CİNDOĞLU Çiğdem , GÜLER Mehmet , EREN Mehmet Ali , SABUNCU Tevfik
Published: April 2020

Amaç: Hipertiroidizm, yüksek serbest triiyodotironin (serbest T3) ve / veya serbest tiroksin düzeyleri (serbest T4) ile birlikte subnormal (genellikle saptanamayan) bir serum tirotropin (TSH) olarak tanımlanır. Endojen hipertiroidi en sık Graves hastalığı (GH) veya nodüler tiroid hastalığına bağlıdır. GH başta tiroid bezi olmak üzere, göz ve nadiren cildi tutan otoimmün bir hastalıktır. Hastalık genelde hipertiroidiye bağlı semptomlar ile tanınır. Tedavisinde anti-tiroid ilaçlar kullanılmakta olup, bu ilaçlar tiroid hormon sentezinin yanısıra anti-inflamatuar özelliklere de sahiptir. Trombosit/lenfosit (TLO) ve nötrofil/lenfosit (NLO) oranları ise rutin kan sayımından elde edilen, ucuz ve tekrarlanabilir, sistemik inflamasyon belirteçleridir. Hipertirodide tedavi öncesi ve tedavi sonrası TLO ve NLO’ nın değerlendirilmesi amaçlanmıştır.Materyal ve Metod: Çalışmaya Harran Üniversitesi Tıp Fakültesi Endokrinoloji Polikliniği’ne başvuran hastaların geçmişe yönelik kayıtları incelenerek hipertiroidi tanısı alan ve medikal tedavi başlanan hastalar alındı. Aktif enfeksiyonu ve hematolojik patolojisi olan hastalar çalışmaya dahil edilmedi. Hastaların kayıtlarından tanı anındaki ve 3-6 ay sonraki laboratuvar sonuçları değerlendirildi. Medikal tedavi öncesi ve sonrası NLO ve TLO değerlerinin karşılaştırılması planlandı.Bulgular: GH grubunda tedavi öncesi ve tedavi sonrası TSH, sT3, sT4, lökosit, nötrofil, lenfosit ve hemoglobin düzeylerinde artış vardı ve bu artış istatistiksel anlamlıydı. Bununla birlikte toksik nodüler guatr (TNG)/multınodüler guatr (MNG) grubunda TSH, sT3, sT4 değerlerinde anlamlı artış varken, lökosit, nötrofil, lenfosit ve hemoglobin düzeylerinde tedavi öncesi ve sonrası anlamlı bir fark yoktu. GH grubunda NLO tedavi sonrası öncesine göre anlamlı yüksekti ancak TLO’nda anlamlı fark gözlenmediSonuç: Hipertiroidi özellikle en sık nedeni olan GH hemotolojik parametrelerde çeşitli mekanızmalarla değişiklik yapabilmektedir. Antitiroid ilaçlar tiroid hormon düzeyleriyle birlikte kan sayımında da değişikliklere neden olur
EFEKTIVITAS PEMBERIAN SALEP EKSTRAK ETANOL DAUN ANTING – ANTING (Acalypha indica Linn.) TERHADAP KESEMBUHAN LUKA INSISI PADA MENCIT (Mus musculus)
Authors: Laut Meity Marviana , Ndaong Nemay , Utami Tri , Junersi Maria , Bria Seran Yovita
Published: April 2020

Regenerasi dan pemulihan jaringan luka merupakan proses fisiologi normal tubuh dalam merespon perlukaan untuk mengembalikan integritas dan fungsi normal kulit. Kesembuhan luka dapat dipercepat dengan pemberian obat kimia maupun obat alami. Salep betadine 10% adalah obat kimia yang sering digunakan dalam perawatan luka untuk menstimulasi penyembuhan luka. Sedangkan, tanaman anting – anting (Acalypha indica) diketahui memiliki aktivitas antiinflamasi, antibakteri, antioksidan, dan antiulser. Daun anting – anting telah lama digunakan oleh masyarakat lokal di NTT untuk mengobati luka dan gangguan kulit lainnya pada ternak peliharaannya. Penelitian ini bertujuan untuk mengetahui gambaran makroskopik dan jumlah fibroblas pada kesembuhan luka insisi pada mencit yang diberi terapi salep ekstrak etanol daun anting – anting (EEDAA), sekaligus sebagai bukti empiris fitofarmaka ini bagi masyarakat lokal di NTT. Penelitian ini bersifat eksperimental laboratorik, menggunakan 30 ekor mencit jantan sehat, berumur 3-4 bulan dengan berat badan berkisar 30-40g. Mencit dibagi dalam 5 kelompok yaitu kelompok kontrol negatif (KN) dan positif (KP) yang masing – masing diaplikasikan basis salep vaselin album dan salep betadine 10%; serta tiga kelompok perlakuan yang masing – masing diberikan salep EEDAA konsentrasi 5%, 10% dan 20%. Setiap kelompok dibuat luka sayat pada area dorsum, dengan ukuran panjang 1.5 cm dengan kedalaman 2 mm. Bahan topikal diberikan sebanyak 2 kali/hari. Pengampilan sampel jaringan luka dilakukan pada hari ke-3, ke-7 dan ke-14. Hasil penelitian menunjukkan bahwa pemberian salep EEDAA konsentrasi 10% menunjukkan kesembuhan luka yang lebih cepat dan optimal dibandingkan dengan salep betadine 10%, salep EEDAA 5% dan 20%.
Laporan Kasus: Orchiectomy Pada Anjing Penderita Cryptorrchid Bilateral
Authors: Tophianong Tarsisius Considus , Utami Tri
Published: April 2020

Cryptorrchid is the most common congenital defect found in dogs and cats. Cryptorrchid is a failure condition of one or both testicle to descend into the scrotum. On 2nd March 2019 an examination and treatment of two bilateral cryptorrchid’s dogs  were done at the Praktik Dokter Hewan Bersama Grace Vetcare. The first patient’s identity is domestic dog, 3 years old, brown hairs, weigh 13 kg called name Iro. The second patient’s identity is domestic dog, 1.5 years old, brown hairs, weigh 15.5 kg called name Jacky. Based on physical examination and ultrasound examination, two dogs were diagnosed Bilateral Inguinal Cryptorrchid. Management treatment of both patients were done by orchiectomy operation. Orchiectomies were done by an open method, which is making incision in the left and right lateral inguinal region of the penis. This operation was done to minimize the risk of sertoli cell tumor (sertolioma). Orchiectomy is the only medical procedure that was recommended for cryptorchid treatment.
SENSITIVITAS ANTIMIKROBA TERHADAP BAKTERI ESCHERICHIA COLI YANG DIISOLASI DARI UDANG DI PASAR KEPUTRAN SURABAYA
Authors: Rahmaniar Reina Puspita , Widhowati Dyah , Hidayah Nurul
Published: April 2020

The aimed of this study was to identify antibiotic Resistance of  Escherichia coli isolated from Shrimp. There were 20 samples taken and isolated on surface of Eosin Methilen Blue Agar. E.coli produced metalic green colonies. Samples identified as E.coli based on macroscopic features and morphology of colonies, microscopic examination with gram staining and biochemical tests. The antibiotic sensitivity was determined through a standard antimicrobial disk diffusion test. The results of this study showed that 9 samples were bacteria of the spesies  E. coli. Based on the results of antibiotic sensitivity test, it was found that 100 % of E. coli isolates were resistant to Amoxycillin 20 µg and 22,2 % of isolates are resistant to ampicillin 10 µg. Antibiotics Tetracycline 30 µg and Chloramphenicol 30 µg were 100 % sensitive. Gentamicin 10 µg showed that 77,8 % sensitive and 22,2 % intermediet. The precence of antibiotic resistance of betalaktam antibiotics makes it especially important to monitor antimicrobial susceptibility and mechanisms of resistance of E.coli isolated from shrimp, because new mechanisms of resistance occurring in animals may enter the food chain and its be  transferred to the human. This importance of  cooperation between sectors in order to monitor antimicrobial resistance.
LAPORAN KASUS: DIAGNOSTIK PENCITRAAN ULTRASONOGRAFI DAN GAMBARAN DARAH PADA ANJING GOLDEN RETRIEVER PENDERITA PYOMETRA TERBUKA
Authors: Tophianong Tarsisius Considus , Utami Tri
Published: April 2020

Piometra adalah gangguan reproduksi yang terjadi pada anjing berusia muda dan sangat umum pada anjing berusia lebih dari 8 tahun. Pada tanggal 14 Februari 2019 seekor anjing Golden Retriever berjenis kelamin betina, berusia 8 tahun bernama Chelsea dibawa pemilik ke tempat Praktik Dokter Hewan Bersama (PDHB) Grace Vet Care. Riwayat kasus anjing Chelsea 1 x beranak pada tahun 2016 dengan kelahiran eutokia/normal, tidak ada riwayat operasi ovariahisterektomi dan gejala klinis berupa discharge berwarna kecoklatan dengan aroma amis menyengat dari vulva, nafsu makan menghilang, muntah, frekuensi pernafasan 92x/menit, frekuensi pulsus/nadi 80 x/menit dan suhu tubuh 38.90C. Pernafasan dengan ritme cepat dan dalam (terengah-engah/panting), palpasi pada kelenjar parotidea kiri mengalami pembengkakan. Auskultasi jantung terdengar cepat dan kuat. Palpasi pada ventrolateral abdomen mengalami distensi tanpa fluktuasi. Hasil pemeriksaan darah menunjukkan terjadinya trombositopenia, neutropenia, limfositosis, azotemia, hiperproteinemia, hiperglobulinemia dengan rasio albumin:globulin normal. Berdasarkan hasil pemeriksaan  USG transabdominal terlihat pembesaran ukuran uterus dan penurunan echogenitas (anechoic) pada lumen uterus. Berdasarkan riwayat reproduksi dan operasi, observasi klinis, pemeriksaan klinis dan organ reproduksi, hematologi analisis, palpasi abdomen dan diagnosa pencitraan ultrasonografi (USG) anjing Chelsea terdiagnosa piometra terbuka.
Margen positivo (R1) en la biopsia intraoperatoria durante una gastrectomía total por cáncer gástrico
Authors: Venturelli Muñoz Francisco José
Published: April 2020

El cáncer gástrico es una patología de alta incidencia en Chile. Afortunadamente es baja la incidencia de márgenes R1 cuando se realiza una cirugía con intención curativa. Al tener un tumor subcardial o cardial es perentorio realizar una biopsia rápida (intraoperatoria),  en caso que ésta resulte positiva, es difícil tomar una decisión sobre qué realizar a continuación, ya que el realizar una esofagoyeyunoanastomosis intratorácica aumenta el riesgo quirúrgico. Para esto, es de suma importancia tener la información de las características histopatológicas del tumor, el riesgo de filtración, la recurrencia, la sobrevida, las terapias adyuvantes y la realidad país. Se realizó una revisión de la literatura con el fin de poder guiar la toma de decisiones.
TRATAMIENTO QUIRURGICO DE LA PERICARDITIS PURULENTA. REPORTE DE UN CASO.
Authors: Valdés Dupeyrón Osvaldo
Published: April 2020

Introduccion: La pericarditis es la enfermedad del pericardio más presente en la práctica médica. La pericarditis purulenta representa el 5% de las pericarditis, con una mortalidad de  hasta el 40%.Caso Clínico: Se presenta un paciente masculino, de 27 años de edad, con antecedentes de hipotiroidismo que ingresa con tos y expectoración amarillenta, asociado a fiebre, que resolvió con tratamiento antibiótico. Un mes después, reingresa con dolor abdominal,  astenia y  disnea intensa que no tolera el decúbito. Se indica ecocardiograma, que diagnostica derrame pericárdico severo, con colapso de cavidades derechas. Se procedió a pericardiocentesis de emergencia, donde se extrajeron 450 mililitros de líquido purulento. En el seguimiento ecocardiográfico a las 48 horas, se observa aumento del derrame, por lo que se decide tratamiento quirúrgico, mediante toracotomia anterolateral izquierda, encontrando derrame purulento y  engrosamiento pericárdico de 6 mm, con multiples adherencias. Se indica pericardiectomia parcial. El paciente evolucionó favorablemente, egresándose 7 días posteriores a la cirugía.
Técnica de linfadenectomía y resección del lecho vesicular laparoscópica por cáncer vesícula biliar incidental
Authors: Castillo Henriquez Felipe , De Aretxabala Urquiza Xabier , Rencoret Palma Guillermo , Vivanco Lacalle Marcelo , Solano Valencia Nicolas , Hepp Kuschel Juan
Published: April 2020

El cáncer de vesícula es infrecuente a nivel mundial, a diferencia de su alta incidencia en Chile. Su pronóstico es malo en general, y dependerá de su forma de presentación, siendo mejor en los casos diagnosticados después de una colecistectomía laparoscópica por patología benigna. La reintervención, que incluye la resección hepática y linfadenectomía, es el pilar de la terapia curativa en esta neoplasiaPresentamos la descripción de la técnica quirúrgica realizada en los pacientes con cáncer de vesícula de diagnóstico incidental, en el Servicio de Cirugía de Clínica Alemana de Santiago y en el Hospital de la Fuerza Aérea de Chile.El abordaje laparoscópico representa una alternativa quirúrgica válida en el tratamiento de pacientes con cáncer de vesícula biliar diagnosticados después de la colecistectomía.La estandarización de la técnica debiera contribuir a su mayor empleo y a la obtención de buenos resultados desde un punto de vista oncológico
Manejo de la fístula anorrectal compleja. LIFT, colgajo de avance y otras técnicas.
Authors: Readi Vallejos Alejandro , Salas Ocaranza Roberto Ignacio
Published: April 2020

Las fístulas anorrectales complejas son un desafío para el coloproctólogo. Son una patología frecuente que afecta la calidad de vida de los pacientes. La patogénesis aún no esta clara, estarían involucradas citoquinas y el proceso de transición de epitelio a mesénquima. El gold estandar para su estudio es la resonancia nuclear magnética, su uso por si mismo disminuye la recurrencia. El objetivo del tratamiento es lograr la curación sin afectar la función del esfínter evitando las recidivas. Existen múltiples técnicas, siendo la de mayor aceptación la ligadura interesfinteriana del trayecto fistuloso, con tasa de curación sobre el 70%, con mínimo impacto en continencia. Esta revisión incluye otras técnicas como el colgajo endorrectal de avance, uso de sellante, Permacol, células madres, Anal fistula plug, Video asisted anal fistula treatment, Over the scope clip y  Fístula laser closure.
Seudoquiste mediastinal y fistulización pleural, excepcional complicación de una pancreatitis.
Authors: Hernández Negrin Rodrigo , Pontillo Mauricio , Olivera Eduardo , Rodríguez Gustavo
Published: April 2020

ResumenIntroducción: Las complicaciones torácicas secundarias a pancreatitis aguda son excepcionales y más aún la presencia de un pseudoquiste mediastinal.Caso clínico: Hombre de 36 años. Consumidor de marihuana y alcohol. Historia de 6 meses de dolor abdominal y adelgazamiento de 20 kilos. Instalando en la evolución sintomatología respiratoria.Discusión: Se discuten las formas de presentación de esta entidad. Sus etiologías más frecuentes. Se hace énfasis en el rol de la imagenología así como en el análisis del líquido pleural.El enfoque terapéutico es conservador al inicio y en algunos pacientes es quirúrgico en la evolución; con diversas opciones.
LUGAR E MEMÓRIA: A VIDA CANGACEIRA DO BANDO DOS MARCELINOS EM BARBALHA - CE
Authors: Costa Ana Paula Rodrigues da
Published: April 2020

O trabalho em questão discorre sobre a abordagem dos conceitos de lugar e memória a partir da geografia humanista, apresentando como objeto de estudo o bando de cangaceiros dos Marcelinos no Cariri cearense, tendo como recorte espacial o município de Barbalha. O texto apresenta um apanhado geral sobre o movimento do cangaço para, em seguida, apresentar o bando dos Marcelinos e alguns lugares de sua atuação em Barbalha. Para contextualizar o tema, apresenta-se a interseção entre lugar e memória como definições relevantes para o entendimento do movimento do cangaço.

Palavras-chave: Bando dos Marcelinos; Cangaço; Lugar; Memória; Geografia Humanista.

 

RESUMEN

El trabajo en cuestión discurre sobre el abordaje de los conceptos de lugar y memoria a partir de la geografía humanista, presentando como objeto de estudio el bando de “cangaceiros” de los Marcelinos en el Cariri cearense, teniendo como recorte espacial el municipio de Barbalha. El texto presenta un recuento general sobre el movimiento del “cangaço”, enseguida, presentar el bando de los Marcelinos y algunos sitios de su actuación en Barbalha. Para contextualizar el tema, se presenta la intersección entre lugar y memoria como definiciones relevantes para el entendimiento del movimiento del “cangaço”.

Palabras clave: Bando de los Marcelinos; Cangaço; Lugar; Memoria; Geografía Humanista.

 

ABSTRACT

This work discusses about the concepts’ approach of place and memory from the humanistic geography, presenting as object of study the Marcelinos’ gang in Cariri – Ceará, having as a spatial clipping the city of Barbalha. The text presents a general overview of the cangaço movement to, then, present the Marcelinos’ gang and some of their actuation places in Barbalha. To contextualize the theme, wepresent the intersection between place and memory as relevant definitions for the understanding of the “cangaço” movement.

Keywords: Marcelinos’ gang; Cangaço; Place; Memory; Humanistic Geography.

 

RÉSUMÉ

Le travail en question discute de l'approche des concepts de lieu et de mémoire de la géographie humaniste, présentant comme objet d'étude la bande de “cangaceiros” des Marcelinos dans le Cariri Ceará, avec la municipalité de Barbalha comme section spatiale. Le texte présente un aperçu du mouvement du “cangaço” puis présente le groupe des Marcelinos et quelques lieux de leur performance à Barbalha. Pour contextualiser le thème, l'intersection entre le lieu et la mémoire est présentée comme des définitions pertinentes pour comprendre le mouvement du “cangaço”.

 

Mots-clés: La bande des Marcelinos; Cangaço; Lieu; Mémoire; Géographie humaniste.
ANALISIS SENTIMEN PENGGUNA TWITTER TERHADAP DOMPET ELEKTRONIK DENGAN METODE LEXICON BASED DAN K – NEAREST NEIGHBOR
Authors: Salim Siti Saidah , Mayary Joanna
Published: April 2020

Analisis sentimen telah menempatkan peran sebagai alat bisnis intelijen. Kemampuan Analisis sentimen antara lain mengekstrak opini publik tentang topik tertentu, produk atau jasa yang di dalam nya terkandung teks-teks yang tidak terstruktur. Analisis sentimen merupakan proses untuk memahami, mengekstrak, dan mengolah data tekstual secara otomatis untuk mendapatkan informasi yang akurat, penerapannya pada transaksi elektronik mempengaruhi kebutuhan gaya hidup konsumen dan aktivitas berbelanja. Dompet elektronik adalah suatu metode pembayaran yang terbaru di Indonesia. Dompet elektronik diistilahkan sebagai e-wallet, dompet digital, digital wallet atau electronic wallet. Penelitian ini mengadopsi analisis sentimen dengan metode Lexicon Based dan K-Nearest Neighbor. Tahapan penelitian terdiri dari analisis sumber data, preprocessing data, klasifikasi sentimen dengan metode Lexicon Based untuk menentukan sentimen positif dan negatif, klasifikasi dengan metode K-Nearest Neighbor untuk perhitungan akurasi dengan confusion matrix, visualisasi wordcloud dan histogram serta tampilan menggunakan packages shiny RStudio. Metode Lexicon Based menggunakan data OVO sebanyak 357 tweets, data GOPAY sebanyak 337 tweets, dan data LinkAja sebanyak 255 tweets. Hasil akhir perhitungan metode K-Nearest Neighbor dengan confusion matrix untuk tweet OVO diperoleh nilai akurasi sebesar 86,91%, tweet Gopay diperoleh nilai akurasi sebesar 94,05%, serta tweet LinkAja diperoleh nilai akurasi sebesar 76,31%.
ANALISIS PERFORMA PROGRESSIVE WEB APPLICATION (PWA) PADA PERANGKAT MOBILE
Authors: Kurniawan Antonius Angga
Published: April 2020

Diantara aplikasi web dan aplikasi native terdapat kesenjangan yang menimbulkan permasalahan. Aplikasi web membutuhkan browser dan koneksi yang baik untuk membuka aplikasi, sedangkan aplikasi native membutuhkan penyedia aplikasi seperti Google PlayStore dan App Store. Pengguna juga memerlukan ruang memori yang cukup untuk sebuah aplikasi yang diinginkan dan tidak semua aplikasi mendukung perangkat yang digunakan. Untuk mengatasi kesenjangan ini, Google menciptakan metode baru dalam pengembangan web. Metode itu adalah Progressive Web Application (PWA). Tujuan dari penelitian ini adalah untuk menganalisis fitur dan kemampuan dari PWA dengan melakukan uji coba pada situs web PWA di mobile dengan aspek penilaian performance, accessibility, best practices, seo, page size, load time, dan penerapan PWA itu sendiri seperti (fast and reliable, installable, pwa optimization). Pengujian juga dilakukan dengan membuktikan fitur dari PWA pada sebuah aplikasi web e-commerce menggunakan mobile. Hasil yang didapatkan menunjukkan bahwa PWA memiliki kemampuan dan fitur yang sangat baik sebagai pengembangan dari aplikasi web dan dapat membantu kesenjangan antara aplikasi web dan aplikasi native.
Cross-polarization effects in sheared 2D grating couplers in a photonic BiCMOS technology
Authors: Georgieva Galina , Voigt Karsten , Mai Christian , Seiler Pascal M. , Petermann Klaus , Zimmermann Lars
Published: April 2020

We investigate numerically and experimentally sheared 2D grating couplers in a photonic BiCMOS technology with a focus on their splitting behavior. Two realization forms of a waveguide-to-grating shear angle are considered. The cross-polarization used as a figure-of-merit is shown to be strongly dependent on the grating perturbation strength and is a crucial limitation not only for the grating splitting performance, but also for its coupling efficiency.
Stock Market Analysis using Data Visualization
Authors:   SCOPE, VIT, Vellore, India, Gupta Bharat , Bhardwaj Shefali ,   SENSE, VIT, Vellore, India, Govinda K. ,   SCOPE, VIT, Vellore, India, R Rajkumar. ,   SCOPE, VIT, Vellore, India
Published: April 2020

Stock market is an important part of the economy of any country. People generally use stocks as an investment and try to get a profit out of them. Investing in the stock market is a huge risk-return. One bad decision can lead to huge losses while one good decision can result in good profit. To make sure that our investment decisions are not bad, one must choose the right stock. In this project we have tried to do the same. We have incorporated the functions to view data like closing prices, highs, lows etc. Using this data one can know the general trend of some stock but how to know whether the stock is risky or not. In this paper, we implemented two algorithms, namely Bootstrap method and Monte Carlo simulation for risk analysis.
Secure Verifiable Outsourcing Collection of Big Data in IoV using Cloud Environments
Authors:   Department of Information Technology ,M.Kumarasamy college of Engineering /Under Anna University,Karur,India., Valarmathi* N. , Annapoorani S. ,   Department of Information Technology ,M.Kumarasamy college of Engineering /Under Anna university,Karur,India
Published: April 2020

By the growth of vehicular communique technology, international gadgets can live interactive and are associated with the Internet. Normally, cars in VANETs have to periodically transmit protection messages. Since safety messages encompass net web page visitor’s associated data and are subtle to locality privacy, it's far essential to make certain obscurity, reliability, and traceability the posted. Supportive verbal exchange is a lively method for vehicular transportations to development Wi-Fi transmission capability and trustworthiness in fifth-technology (5G) trivial-mobile set-ups. In this paper, we check protection conversation approximately internet net web page net page website traffic associated information, accidents or particular privacy aware information are inside the shape of video reporting commercial enterprise organization. This company is completed a machine to proper now the report films to fantastic authorities and ambulance in a well timed way. Conversely, due to immoderate besides at ease avenue website online visitors information, the vehicular cloud is built scheduled lively belongings; as in keeping with a surrender very last results, it critiques numerous intrinsic traumatic situations, which growth the complexity of its implementations. Therefore, we are able to format relaxed communiqué tool using cryptography approach and furthermore located into effect greater applicable function-based completely get admission to control mechanism (ERBAC) to offer the functionality to the authority for viewing the video files in cloud storage device.