bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiorespiratory fitness modulates the acute flow-mediated dilation response following high-intensity but not moderate-intensity exercise in elderly men
Authors: Bailey Tom G. , Perissiou Maria , Windsor Mark , Russell Fraser , Golledge Jonathan , Green Daniel J. , Askew Christopher D.
Published: February 2017

Impaired endothelial function is observed with aging and in those with low cardiorespiratory fitness (V̇o2peak). Improvements in endothelial function with exercise training are somewhat dependent on the intensity of exercise. While the acute stimulus for this improvement is not completely understood, it may, in part, be due to the flow-mediated dilation (FMD) response to acute exercise. We examined the hypothesis that exercise intensity alters the brachial (systemic) FMD response in elderly men and is modulated by V̇o2peak. Forty-seven elderly men were stratified into lower (V̇o2peak = 24.3 ± 2.9 ml·kg−1·min−1; n = 27) and higher fit groups (V̇o2peak = 35.4 ± 5.5 ml·kg−1·min−1; n = 20) after a test of cycling peak power output (PPO). In randomized order, participants undertook moderate-intensity continuous exercise (MICE; 40% PPO) or high-intensity interval cycling exercise (HIIE; 70% PPO) or no-exercise control. Brachial FMD was assessed at rest and 10 and 60 min after exercise. FMD increased after MICE in both groups {increase of 0.86% [95% confidence interval (CI), 0.17–1.56], P = 0.01} and normalized after 60 min. In the lower fit group, FMD was reduced after HIIE [reduction of 0.85% (95% CI, 0.12–1.58), P = 0.02] and remained decreased at 60 min. In the higher fit group, FMD was unchanged immediately after HIIE and increased after 60 min [increase of 1.52% (95% CI, 0.41–2.62), P < 0.01, which was correlated with V̇o2peak, r = 0.41; P < 0.01]. In the no-exercise control, FMD was reduced in both groups after 60 min ( P = 0.05). Exercise intensity alters the acute FMD response in elderly men and V̇o2peak modulates the FMD response following HIIE but not MICE. The sustained decrease in FMD in the lower fit group following HIIE may represent a signal for vascular adaptation or endothelial fatigue.

NEW & NOTEWORTHY This study is the first to show that moderate-intensity continuous cycling exercise increased flow-mediated dilation (FMD) transiently before normalization of FMD after 1 h, irrespective of cardiorespiratory fitness level in elderly men. Interestingly, we show increased FMD after high-intensity cycling exercise in higher fit men, with a sustained reduction in FMD in lower fit men. The prolonged reduction in FMD after high-intensity cycling exercise may be associated with future vascular adaptation but may also reflect a period of increased cardiovascular risk in lower fit elderly men.
AAV-mediated delivery of optogenetic constructs to the macaque brain triggers humoral immune responses
Authors: Mendoza Skyler D. , El-Shamayleh Yasmine , Horwitz Gregory D.
Published: February 2017

Gene delivery to the primate central nervous system via recombinant adeno-associated viral vectors (AAV) allows neurophysiologists to control and observe neural activity precisely. A current limitation of this approach is variability in vector transduction efficiency. Low levels of transduction can foil experimental manipulations, prompting vector readministration. The ability to make multiple vector injections into the same animal, even in cases where successful vector transduction has already been achieved, is also desirable. However, vector readministration has consequences for humoral immunity and gene delivery that depend on vector dosage and route of administration in complex ways. As part of optogenetic experiments in rhesus monkeys, we analyzed blood sera collected before and after AAV injections into the brain and quantified neutralizing antibodies to AAV using an in vitro assay. We found that injections of AAV1 and AAV9 vectors elevated neutralizing antibody titers consistently. These immune responses were specific to the serotype injected and were long lasting. These results demonstrate that optogenetic manipulations in monkeys trigger immune responses to AAV capsids, suggesting that vector readministration may have a higher likelihood of success by avoiding serotypes injected previously.

NEW & NOTEWORTHY Adeno-associated viral vector (AAV)-mediated gene delivery is a valuable tool for neurophysiology, but variability in transduction efficiency remains a bottleneck for experimental success. Repeated vector injections can help overcome this limitation but affect humoral immune state and transgene expression in ways that are poorly understood. We show that AAV vector injections into the primate central nervous system trigger long-lasting and serotype-specific immune responses, raising the possibility that switching serotypes may promote successful vector readministration.
Bone Cell Bioenergetics and Skeletal Energy Homeostasis
Authors: Riddle Ryan C. , Clemens Thomas L.
Published: February 2017

The rising incidence of metabolic diseases worldwide has prompted renewed interest in the study of intermediary metabolism and cellular bioenergetics. The application of modern biochemical methods for quantitating fuel substrate metabolism with advanced mouse genetic approaches has greatly increased understanding of the mechanisms that integrate energy metabolism in the whole organism. Examination of the intermediary metabolism of skeletal cells has been sparked by a series of unanticipated observations in genetically modified mice that suggest the existence of novel endocrine pathways through which bone cells communicate their energy status to other centers of metabolic control. The recognition of this expanded role of the skeleton has in turn led to new lines of inquiry directed at defining the fuel requirements and bioenergetic properties of bone cells. This article provides a comprehensive review of historical and contemporary studies on the metabolic properties of bone cells and the mechanisms that control energy substrate utilization and bioenergetics. Special attention is devoted to identifying gaps in our current understanding of this new area of skeletal biology that will require additional research to better define the physiological significance of skeletal cell bioenergetics in human health and disease.
Excessive Exercise Habits in Marathoners as Novel Indicators of Masked Hypertension
Authors: Kim Young-Joo , Park Yongbum , Kang Duk-Ho , Kim Chul-Hyun
Published: February 2017

Background. Excessive exercise such as marathon running increases the risk of cardiovascular events that may be related to myocardial infarction and sudden death. We aimed to investigate that the exercise characteristics can be used as a novel indicator of masked hypertension. Methods. A total of 571 middle-aged recreational male marathoners were assigned to a high blood pressure group (HBPG; n=214) or a normal blood pressure group (NBPG; n=357). A graded exercise test was used to examine the hemodynamic response and cardiac events, and the personal exercise characteristics were recorded. Results. Systolic blood pressure and diastolic blood pressure were higher in the HBPG than in the NBPG (p<0.05, all). The marathon history, exercise intensity, and time were longer and higher, whereas the marathon completion duration was shorter in the HBPG than in NBPG (p<0.05, all). HBPG showed a higher frequency of alcohol consumption than NBPG (p<0.05). Conclusion. More excessive exercise characteristics than the normative individuals. If the individuals exhibit high blood pressure during rest as well as exercise, the exercise characteristics could be used as a novel indicator for masked hypertension.
Effect of Film-Forming Polymers on Release of Naftifine Hydrochloride from Nail Lacquers
Authors: Šveikauskaitė Indrė , Briedis Vitalis
Published: February 2017

The successful topical therapy of onychomycosis depends on effective drug release and penetration into nail, which can be achieved by using an adequately developed delivery system. This study evaluated and compared effect of film-forming polymers Eudragit RL100, Eudragit RS100, and ethyl cellulose on naftifine hydrochloride release from experimental nail lacquer formulations. Quality of formulations was evaluated by determining drying time and water resistance. Interactions between active pharmaceutical ingredient and excipients were investigated using microcalorimetry and FT-IR. Optimization of nail lacquer formulations was performed by naftifine hydrochloride release testing. Release of naftifine hydrochloride increased with increasing concentration of Eudragit RL100. Plasticizer triacetin affected the release of naftifine hydrochloride, when Eudragit RS100 polymer was used. Ethyl cellulose polymer was determined to be not applicable for naftifine hydrochloride nail lacquer formulations. Two compositions of nail lacquers were optimized and could be used in further development of transungual delivery systems.
Effects of Crack on Vibration Characteristics of Mistuned Rotated Blades
Authors: Xu Hailong , Chen Zhongsheng , Yang Yongmin , Tao Limin , Chen Xuefeng
Published: February 2017

Rotated blades are key mechanical components in turbine and high cycle fatigues often induce blade cracks. Meanwhile, mistuning is inevitable in rotated blades, which often makes it much difficult to detect cracks. In order to solve this problem, it is important and necessary to study effects of crack on vibration characteristics of mistuned rotated blades (MRBs). Firstly, a lumped-parameter model is established based on coupled multiple blades, where mistuned stiffness with normal distribution is introduced. Next, a breathing crack model is adopted and eigenvalue analysis is used in coupled lumped-parameter model. Then, numerical analysis is done and effects of depths and positions of a crack on natural frequency, vibration amplitude, and vibration localization parameters are studied. The results show that a crack causes natural frequency decease and vibration amplitude increase of cracked blade. Bifurcations will occur due to a breathing crack. Furthermore, based on natural frequencies and vibration amplitudes, variational factors are defined to detect a crack in MRBs, which are validated by numerical simulations. Thus, the proposed method provides theoretical guidance for crack detection in MRBs.
RNA-Based Stable Isotope Probing SuggestsAllobaculumspp. as Particularly Active Glucose Assimilators in a Complex Murine Microbiota Cultured In Vitro
Authors: Herrmann Elena , Young Wayne , Rosendale Douglas , Reichert-Grimm Verena , Riedel Christian U. , Conrad Ralf , Egert Markus
Published: February 2017

RNA-based stable isotope probing (RNA-SIP) and metabolic profiling were used to detect actively glucose-consuming bacteria in a complex microbial community obtained from a murine model system. A faeces-derived microbiota was incubated under anaerobic conditions for 0, 2, and 4 h with 40 mM [U13C]glucose. Isopycnic density gradient ultracentrifugation and fractionation of isolated RNA into labeled and unlabeled fractions followed by 16S rRNA sequencing showed a quick adaptation of the bacterial community in response to the added sugar, which was dominated by unclassified Lachnospiraceae species. Inspection of distinct fractions of isotope-labeled RNA revealedAllobaculumspp. as particularly active glucose utilizers in the system, as the corresponding RNA showed significantly higher proportions among the labeled RNA. With time, the labeled sugar was used by a wider spectrum of faecal bacteria. Metabolic profiling indicated rapid fermentation of [U13C]glucose, with lactate, acetate, and propionate being the principal13C-labeled fermentation products, and suggested that “cross-feeding” occurred in the system. RNA-SIP combined with metabolic profiling of13C-labeled products allowed insights into the microbial assimilation of a general model substrate, demonstrating the appropriateness of this technology to study assimilation processes of nutritionally more relevant substrates, for example, prebiotic carbohydrates, in the gut microbiota of mice as a model system.
The Combination of MBP and BCG-Induced Dendritic Cell Maturation through TLR2/TLR4 Promotes Th1 Activation In Vitro and Vivo
Authors: Jiang LiNa , Liu GuoMu , Ni WeiHua , Zhang NanNan , Jie Jing , Xie Fei , Tai GuiXiang
Published: February 2017

To explore whether TLR2/TLR4 could be involved in the maturation of dendritic cells and polarization of CD4+T cells induced by dendritic cells stimulated with MBP and BCG, in vitro and in vivo experiments using TLR2−/−or TLR4−/−mice were employed. MBP and BCG elevated CD80, CD86 and MHC class II expressed on dendritic cells and increased IL-12 protein, induced DC maturation, and indirectly promoted Th1 activation. Moreover, MBP and BCG upregulated costimulatory molecules on DCs in a TLR2- and TLR4-dependent manner. The levels of IFN-γ, IL-4, and IL-10 in CD4+T cells cocultured with dendritic cells from different types of mice were determined with ELISPOT or ELISA method. TLR2/TLR4 is important in the maturation and activation of dendritic cells and the activation of Th1 cells induced by stimulation with MBP and BCG. In conclusion, TLR2 and TLR4 play an important role in the upregulation of costimulatory molecules and MHC class II molecules on dendritic cells and the activation of Th1 cells induced by stimulation with MBP and BCG. The results above indicate that the combination of MBP and BCG induced the maturation and activation of dendritic cells and promoted Th1 activation via TLR2/TLR4.
Performance Analysis of Spotify® for Android with Model-Based Testing
Authors: Espada Ana Rosario , Gallardo María del Mar , Salmerón Alberto , Merino Pedro
Published: February 2017

This paper presents the foundations and the real use of a tool to automatically detect anomalies in Internet traffic produced by mobile applications. In particular, our MVE tool is focused on analyzing the impact that user interactions have on the traffic produced and received by the smartphones. To make the analysis exhaustive with regard to the potential user behaviors, we follow a model-based approach to automatically generate test cases to be executed on the smartphones. In addition, we make use of a specification language to define traffic patterns to be compared with the actual traffic in the device. MVE also includes monitoring and verification support to detect executions that do not fit the patterns. In these cases, the developer will obtain detailed information on the user actions that produce the anomaly in order to improve the application. To validate the approach, the paper presents an experimental study with the well-known Spotify app for Android, in which we detected some interesting behaviors. For instance, some HTTP connections do not end successfully due to timeout errors from the remote Spotify service.
Modelling of Rough Contact between Linear Viscoelastic Materials
Authors: Spinu Sergiu , Cerlinca Delia
Published: February 2017

The important gradients of stress arising in rough mechanical contacts due to interaction at the asperity level are responsible for damage mechanisms like rolling contact fatigue, wear, or crack propagation. The deterministic approach to this process requires computationally effective numerical solutions, capable of handling very fine meshes that capture the particular features of the investigated contacting surface. The spatial discretization needs to be supported by temporal sampling of the simulation window when time-dependent viscoelastic constitutive laws are considered in the description of the material response. Moreover, when real surface microtopography is considered, steep slopes inevitably lead to localized plastic deformation at the tip of the asperities that are first brought into contact. A computer model for the rough contact of linear viscoelastic materials, capable of handling deterministic contact geometry, complex viscoelastic models, and arbitrary loading histories, is advanced in this paper. Plasticity is considered in a simplified manner that preserves the information regarding the contact area and the pressure distribution without computing the residual strains and stresses. The model is expected to predict the contact behavior of deterministic rough surfaces as resulting from practical engineering applications, thus assisting the design of durable machine elements using elastomers or rubbers.
Bifurcation Analysis with Aerodynamic-Structure Uncertainties by the Nonintrusive PCE Method
Authors: Wang Linpeng , Dai Yuting , Yang Chao
Published: February 2017

An aeroelastic model for airfoil with a third-order stiffness in both pitch and plunge degree of freedom (DOF) and the modified Leishman–Beddoes (LB) model were built and validated. The nonintrusive polynomial chaos expansion (PCE) based on tensor product is applied to quantify the uncertainty of aerodynamic and structure parameters on the aerodynamic force and aeroelastic behavior. The uncertain limit cycle oscillation (LCO) and bifurcation are simulated in the time domain with the stochastic PCE method. Bifurcation diagrams with uncertainties were quantified. The Monte Carlo simulation (MCS) is also applied for comparison. From the current work, it can be concluded that the nonintrusive polynomial chaos expansion can give an acceptable accuracy and have a much higher calculation efficiency than MCS. For aerodynamic model, uncertainties of aerodynamic parameters affect the aerodynamic force significantly at the stage from separation to stall at upstroke and at the stage from stall to reattach at return. For aeroelastic model, both uncertainties of aerodynamic parameters and structure parameters impact bifurcation position. Structure uncertainty of parameters is more sensitive for bifurcation. When the nonlinear stall flutter and bifurcation are concerned, more attention should be paid to the separation process of aerodynamics and parameters about pitch DOF in structure.
JianPi JieDu Recipe Inhibits Epithelial-to-Mesenchymal Transition in Colorectal Cancer through TGF-β/Smad Mediated Snail/E-Cadherin Expression
Authors: Liu Xuan , Ji Qing , Deng Wanli , Chai Ni , Feng Yuanyuan , Zhou Lihong , Sui Hua , Li Chunpu , Sun Xiaoting , Li Qi
Published: February 2017

JPJD was an ideal alternative traditional Chinese medicine compound in the prevention and treatment of CRC, but its underlying mechanisms has not been fully elucidated. In this study, we demonstrated in vitro that TGF-β-induced EMT promoted the invasion and metastasis of CRC cells, reduced the expression of E-cadherin, and elevated the expression of Vimentin. However, JPJD could inhibit the invasive and migratory ability of TGF-β-stimulated CRC cells in a concentration-dependent manner through increasing the expression of E-cadherin and repressing the expression of Vimentin, as well as the inhibition of TGF-β/Smad signaling pathway. Meanwhile, JPJD reduced the transcriptional activities of EMT-associated factors Snail and E-cadherin during the initiation of TGF-β-induced EMT. In vivo, the results demonstrated that JPJD can significantly inhibit the liver and lung metastasis of orthotopic CRC tumor in nude mice, as well as significantly prolonging the survival time of tumor-bearing in a dose-dependent manner. Additionally, JPJD can upregulate the expression of E-cadherin and Smad2/3 in the cytoplasm and downregulate the expression of Vimentin, p-Smad2/3, and Snail in the orthotopic CRC tumor tissues. In conclusions, our new findings provided evidence that JPJD could inhibit TGF-β-induced EMT in CRC through TGF-β/Smad mediated Snail/E-cadherin expression.
New Approach for Common Fixed Point Theorems viaC-Class Functions inGp-Metric Spaces
Authors: Ansari A. H. , Barakat M. A. , Aydi H.
Published: February 2017

We prove a new approach for some common fixed point results in completeGp-metric spaces for weakly increasing self-mappings satisfyingψ,φ-contractions via the concept ofC-class functions. An example is also provided.
Can Surgery Be Avoided? Exclusive Antibiotic Treatment for Pelvic Actinomycosis
Authors: Ruiz M. P. , Williams E. M. , Markey C. M. , Johnson A. M. , Morales-Ramirez P. B.
Published: February 2017

Pelvic actinomycosis is an uncommon, slowly progressing granulomatous infection that has been associated with the presence of intrauterine devices. Due to its unspecific clinical and radiologic findings, it can mimic pelvic or intra-abdominal malignancy leading to mutilating surgery of high morbidity. Rarely, diagnosis is made preoperatively and in most cases surgical intervention is necessary. The patient in our case is a 42-year-old female with an IUD for 15 years diagnosed with pelvic actinomycosis. Patient was uniquely diagnosed preoperatively through paracentesis and treated conservatively with prolonged antibiotic therapy and without any type of surgical intervention. Follow-up at 1 year showed almost complete radiologic resolution of the inflammatory mass, nutritional recovery, and absence of symptoms. Pelvic actinomycosis can be successfully diagnosed and treated medically without surgical interventions.
Addressing Challenges to Enhance the Bioactives ofWithania somniferathrough Organ, Tissue, and Cell Culture Based Approaches
Authors: Singh Pritika , Guleri Rupam , Angurala Amrita , Kaur Kuldeep , Kaur Kulwinder , Kaul Sunil C. , Wadhwa Renu , Pati Pratap Kumar
Published: February 2017

Withania somniferais a highly valued medicinal plant in traditional home medicine and is known for a wide range of bioactivities. Its commercial cultivation is adversely affected by poor seed viability and germination. Infestation by various pests and pathogens, survival under unfavourable environmental conditions, narrow genetic base, and meager information regarding biosynthesis of secondary metabolites are some of the other existing challenges in the crop. Biotechnological interventions through organ, tissue, and cell culture provide promising options for addressing some of these issues.In vitropropagation facilitates conservation and sustainable utilization of the existing germplasms and broadening the genetic base. It would also provide means for efficient and rapid mass propagation of elite chemotypes and generating uniform plant material round the year for experimentation and industrial applications. The potential ofin vitrocell/organ cultures for the production of therapeutically valuable compounds and their large-scale production in bioreactors has received significant attention in recent years.In vitroculture system further provides distinct advantage for studying various cellular and molecular processes leading to secondary metabolite accumulation and their regulation. Engineering plants through genetic transformation and development of hairy root culture system are powerful strategies for modulation of secondary metabolites. The present review highlights the developments and sketches current scenario in this field.
Multiband Operation and Performance Enhancement of the PIFA Antenna by Using Particle Swarm Optimization and Overlapping Method
Authors: Wakrim L. , Ibnyaich S. , Hassani M. M.
Published: February 2017

Recently, the demand for wireless devices that support multiband frequency has increased. The integration of such technology in mobile communication system has led to a great demand in developing small size antenna with multiband operation, which is able to operate in the required system. In this paper, a novel type planar inverted F antenna (PIFA) with gridded ground plane structure and overlapping cells is presented. By controlling the overlapping size, we improve the characteristics of the proposed antenna. This antenna is developed to achieve multiband operation with small size and good performance. The particle swarm optimization (PSO) is employed to a PIFA antenna to get rid of the limitations of single band operation by searching the optimal localization and length of linear slots on the ground plane to give triband operation. This PIFA antenna can be integrated to operate for several mobile applications as Bluetooth/WLAN, WIMAX, and 4G (UMTS2100, LTE). The optimized antenna is simulated by both Ansoft HFSS and computer simulation technology microwave studio (CSTMWS) in terms of S-parameters. A good agreement between simulated performances by both software types is achieved. A parametric study is made to analyze the effect of different PIFA parameters on the operating frequency and the reflection coefficient in order to enhance the antenna performances. In these frequency bands, the antenna has nearly omnidirectional radiation pattern.
Experimental Study of Dowel Bar Alternatives Based on Similarity Model Test
Authors: Hu Chichun , Ma Jiexian , Zhao Jianying , Leng Zhen , Jelagin Denis
Published: February 2017

In this study, a small-scaled accelerated loading test based on similarity theory and Accelerated Pavement Analyzer was developed to evaluate dowel bars with different materials and cross-sections. Jointed concrete specimen consisting of one dowel was designed as scaled model for the test, and each specimen was subjected to 864 thousand loading cycles. Deflections between jointed slabs were measured with dial indicators, and strains of the dowel bars were monitored with strain gauges. The load transfer efficiency, differential deflection, and dowel-concrete bearing stress for each case were calculated from these measurements. The test results indicated that the effect of the dowel modulus on load transfer efficiency can be characterized based on the similarity model test developed in the study. Moreover, round steel dowel was found to have similar performance to larger FRP dowel, and elliptical dowel can be preferentially considered in practice.
Geotechnologies and Soil Mapping for Delimitation of Management Zones as an Approach to Precision Viticulture
Authors: Filippini Alba José Maria , Flores Carlos Alberto , Miele Alberto
Published: February 2017

Data of the physical and chemical properties of soils from three vineyards located in Vale dos Vinhedos, Bento Gonçalves, Rio Grande do Sul state, in southern Brazil, were processed. Soil mapping was performed by means of four profiles and the digital elevation model in detailed scale. Then, superficial soils (0–20 cm) were sampled according to a grid pattern. Analysis of variance (ANOVA), kriging, and unsupervised classification methods were applied on physical and chemical data of superficial soils sampled according to grid pattern. This study aimed to compare both methods, the conventional soil mapping and the map produced with superficial soil sampling, about their potential for definition of the management zones, as an approach for precision agriculture. Maps elaborated by conventional soil mapping overlapped partially with the maps derived from superficial sampling, probably due to the specific methodological differences of each case. Anyway, both methods are complementary because of the focus on vertical variability and horizontal variability, respectively. In that sense, slope appears as significant edaphic parameter, due to its control on water circulation in the profile of soil.
T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers
Authors: Mietelska-Porowska Anna , Wojda Urszula
Published: February 2017

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder and the main cause of dementia. The disease is among the leading medical concerns of the modern world, because only symptomatic therapies are available, and no reliable, easily accessible biomarkers exist for AD detection and monitoring. Therefore extensive research is conducted to elucidate the mechanisms of AD pathogenesis, which seems to be heterogeneous and multifactorial. Recently much attention has been given to the neuroinflammation and activation of glial cells in the AD brain. Reports also highlighted the proinflammatory role of T lymphocytes infiltrating the AD brain. However, in AD molecular and cellular alterations involving T cells and immune mediators occur not only in the brain, but also in the blood and the cerebrospinal fluid (CSF). Here we review alterations concerning T lymphocytes and related immune mediators in the AD brain, CSF, and blood and the mechanisms by which peripheral T cells cross the blood brain barrier and the blood-CSF barrier. This knowledge is relevant for better AD therapies and for identification of novel biomarkers for improved AD diagnostics in the blood and the CSF. The data will be reviewed with the special emphasis on possibilities for development of AD biomarkers.
Noninterest Income and Performance of Commercial Banking in China
Authors: Sun Limei , Wu Siqin , Zhu Zili , Stephenson Alec
Published: February 2017

Noninterest income is what most Chinese banks are striving for in recent years because of the vigorous competition among commercial banks due to the increasingly open market and tough regulation from the central bank of China. But the problem is the real effect of noninterest income on profit and risks. A panel threshold model is used with balanced panel dataset of 16 listed Chinese commercial banks, for the period of 2007 to 2013, to investigate the relationship between noninterest income and performance. The findings show two main conclusions: (1) the existence of two thresholds shows that there is nonlinear relationship; (2) there is a general negative correlation between the noninterest income ratio and performance of commercial banks. Furthermore, when the noninterest income ratio is higher than the two thresholds, the negative correlation decreases. Implications of the paper are that the ratio should be controlled in a range or noninterest income will not positively affect the performance, and a high level of performance can be gained only by raising the ratio to a certain level.
Selenium Polysaccharide SPMP-2a fromPleurotus geesteranusAlleviates H2O2-Induced Oxidative Damage in HaCaT Cells
Authors: Sun Yujun , Zhou Cheng , Huang Shoucheng , Jiang Changjun
Published: February 2017

Selenium- (Se-) enriched polysaccharide SPMP-2a was extracted and purified fromPleurotus geesteranus. SPMP-2a is a white flocculent polysaccharide and soluble in water, with a molecular weight of 3.32 × 104 Da. Fourier transform infrared spectroscopy spectral analysis indicated that it belongs to an acid Se polysaccharide withα-D-glucopyranoside bond. The effects of Se polysaccharide SPMP-2a inP. geesteranusagainst hydrogen peroxide- (H2O2-) induced oxidative damage in human keratinocytes (HaCaT) cells were evaluated further. Reduced cell viability and elevated apoptotic rates in H2O2-treated HaCaT cells were proven by MTT and flow cytometry assays. Hoechst 33342 staining revealed chromatin condensations in the nuclei of HaCaT cells. However, with the addition of SPMP-2a, cell viability improved, nuclear condensation declined, and cell apoptotic rates dropped significantly. Ultrastructural observation consistently revealed that treatments with SPMP-2a reduced the number of swollen and vacuolar mitochondria in the H2O2-treated cells compared with the controls. Furthermore, SPMP-2a increased the superoxide dismutase (SOD) and catalase (CAT) activities and reduced reactive oxygen species (ROS) content. Western blot analysis showed that SPMP-2a treatment effectively increased B-cell lymphoma 2 (Bcl-2) protein expression. Therefore, SPMP-2a could improve cellular antioxidant enzyme activities, reduce ROS levels, and increase Bcl-2 protein expression levels, thereby reducing cell apoptosis and protecting HaCaT cells from H2O2-induced oxidative damage.
An Experimental Study on Solidifying Municipal Sewage Sludge through Skeleton Building Using Cement and Coal Gangue
Authors: Yang Jiankang , Lu Haijun , Zhang Xiong , Li Jixiang , Wang Weiwei
Published: February 2017

The municipal sewage sludge typically has very high water content and low shear strength. Conventional methods of lime and cement solidification of municipal sewage sludge often suffer high cost, significant drying shrinkage, frequent cracking, high hydraulic conductivity, and low strength. To overcome these shortcomings, in this paper a skeleton-building method was used to solidify municipal sewage sludge in which coal gangue, cement and clay, and fiber were used as skeleton materials, cementation materials, and filling materials, respectively. Comprehensive laboratory tests including cracking, nitrogen adsorption, triaxial shearing, and permeability tests were performed to determine cracking, pore structure, shear strength, and hydraulic conductivity of municipal sewage sludge solidified with different proportions of coal gangue, cement, fiber, and clay. Based upon the experimental results, the mechanisms of the skeleton building using cement and coal gangue were discussed and factors controlling the mechanical and hydraulic behavior of the solidified soils were analyzed at both microscopic and macroscopic levels. Based upon the test results and analyses, recommendations were made for solidifying municipal sewage sludge through skeleton building using cement and coal gangue. The solidified soils have high soil strength, high resistance to cracking, and low hydraulic conductivity which are sufficient for being used as landfill liner.
Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction
Authors: Wookey Alice F. , Chollangi Tejasvy , Yong Hannah E. J. , Kalionis Bill , Brennecke Shaun P. , Murthi Padma , Georgiou Harry M.
Published: February 2017

Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic (n=9) and nonidiopathic (n=9). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR,p<0.05, Student’st-test) that were strongly associated with idiopathic fetal growth restriction (p<0.01, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (p=0.295, Pearson’s correlation). As such, vitamin D-binding protein may be a factor in unexplained placental dysfunction associated with idiopathic fetal growth restriction and may potentially serve as a biomarker of this disease.
Cervical Rotatory Manipulation Decreases Uniaxial Tensile Properties of Rabbit Atherosclerotic Internal Carotid Artery
Authors: Zhang Shaoqun , Qi Ji , Zhang Lei , Chen Chao , Mondal Shubhro , Ping Kaike , Chen Yili , Li Yikai
Published: February 2017

Objective. To investigate the effects of one of the Chinese massage therapies, cervical rotatory manipulation (CRM), on uniaxial tensile properties of rabbit atherosclerotic internal carotid artery (ICA). Methods. 40 male purebred New Zealand white rabbits were randomly divided into CRM‐Model group, Non‐CRM‐Model group, CRM‐Normal group, and Non‐CRM‐Normal group. After modeling (atherosclerotic model) and intervention (CRM or Non‐CRM), uniaxial tensile tests were performed on the ICAs to assess the differences in tensile mechanical properties between the four groups. Results. Both CRM and modeling were the main effects affecting physiological elastic modulus (PEM) of ICA. PEM in CRM‐Model group was 1.81 times as much as Non‐CRM‐Model group, while the value in CRM‐Model group was 1.34 times as much as CRM‐Normal group. Maximum elastic modulus in CRM‐Model group was 1.80 times as much as CRM‐Normal group. Max strains in CRM‐Model group and Non‐CRM‐Model group were 30.98% and 28.71% lower than CRM‐Normal group and Non‐CRM‐Normal group, respectively. However, whether treated with CRM or not, the uniaxial tensile properties of healthy ICAs were not statistically different. Conclusion. CRM may decrease the uniaxial tensile properties of rabbit arteriosclerotic ICA, but with no effect on normal group. The study will aid in the meaningful explanation of the controversy about the harmfulness of CRM and the suitable population of CRM.
High Magnitude of Social Anxiety Disorder in School Adolescents
Authors: Mekuria Kindie , Mulat Haregwoin , Derajew Habtamu , Mekonen Tesfa , Fekadu Wubalem , Belete Amsalu , Yimer Solomon , Legas Getasew , Menberu Melak , Getnet Asmamaw , Kibret Simegnew
Published: February 2017

Introduction. Social phobia is the most prevalent and chronic type of anxiety disorder worldwide and it affects occupational, educational, and social affairs of the individual. Social phobia is also known for its association with depression and substance use disorder. Objective. The aim of this study was to assess the prevalence and associated factors of social phobia among high school students in Ethiopia. Methods. Cross-sectional study was conducted among 386 randomly selected students. Data were collected using pretested and self-administered questionnaire. Social phobia was assessed by using Social Phobia Inventory (SPIN). Logistic regression was used to analyze the data with 95% confidence interval and variables with p value less than 0.05 were considered as statistically significant. Results. From 386 study participants, 106 (27.5%) of them were positive for social phobia. Being female (AOR = 3.1; 95% CI: 1.82–5.27), current alcohol drinking (AOR = 1.75; 95% CI: 1.03–2.98), poor social support (AOR = 2.40; 95% CI: 1.17–4.92), and living with single parent (AOR = 5.72; 95% CI: 2.98–10.99) were significantly associated with social phobia. Conclusion. The proportion of social phobia was higher compared to previous evidences. School-based youth-friendly mental health services might be helpful to tackle this problem.
Pain Experience and Behavior Management in Pediatric Dentistry: A Comparison between Traditional Local Anesthesia and the Wand Computerized Delivery System
Authors: Garret-Bernardin Annelyse , Cantile Tiziana , D’Antò Vincenzo , Galanakis Alexandros , Fauxpoint Gabriel , Ferrazzano Gianmaria Fabrizio , De Rosa Sara , Vallogini Giulia , Romeo Umberto , Galeotti Angela
Published: February 2017

Aim.To evaluate the pain experience and behavior during dental injection, using the Wand computerized delivery system versus conventional local anesthesia in children and adolescents.Methods.An observational crossover split mouth study was performed on 67 patients (aged 7 to 15 years), requiring local anesthesia for dental treatments in both sides of the dental arch. Patients received both types of injections in two separate appointments, one with the use of a Computer Delivery System (the Wand STA system) and one with the traditional syringe. The following data were recorded: pain rating; changes in heart rate; level of collaboration; patient satisfaction. The data were analyzed using ANOVA for quantitative outcomes and nonparametric analysis (Kruskal–Wallis) for qualitative parameters.Results.The use of the Wand system determined significantly lower pain ratings and lower increase of heart rate than the traditional syringe. During injection, the number of patients showing a relaxed behavior was higher with the Wand than with the traditional local anesthesia. The patient level of satisfaction was higher with the Wand compared to the conventional local anesthesia.Conclusions.The Wand system may provide a less painful injection when compared to the conventional local anesthesia and it seemed to be better tolerated with respect to a traditional syringe.
Fixed Point Theorems for Manageable Contractions with Application to Integral Equations
Authors: Hussain N. , Iqbal I. , Alamri Badriah A. S. , Kutbi M. A.
Published: February 2017

In this paper we utilize the concept of manageable functions to define multivaluedα⁎-η⁎manageable contractions and prove fixed point theorems for such contractions. As applications we deduce certain fixed point theorems which generalize and improve Nadler’s fixed point theorem, Mizoguchi-Takahashi’s fixed point theorem, and some other well-known results in the literature. Also, we give an illustrating example showing that our results are a proper generalization of Nadler’s theorem and provide an application to integral equations.
Orthodontic Management in Aggressive Periodontitis
Authors: Gyawali Rajesh , Bhattarai Bhagabat
Published: February 2017

Aggressive periodontitis is a type of periodontitis with early onset and rapid progression and mostly affecting young adults who occupy a large percentage of orthodontic patients. The role of the orthodontist is important in screening the disease, making a provisional diagnosis, and referring it to a periodontist for immediate treatment. The orthodontist should be aware of the disease not only before starting the appliance therapy, but also during and after the active mechanotherapy. The orthodontic treatment plan, biomechanics, and appliance system may need to be modified to deal with the teeth having reduced periodontal support. With proper force application and oral hygiene maintenance, orthodontic tooth movement is possible without any deleterious effect in the tooth with reduced bone support. With proper motivation and interdisciplinary approach, orthodontic treatment is possible in patients with controlled aggressive periodontitis.
Evidence for Startle Effects due to Externally Induced Lower Limb Movements: Implications in Neurorehabilitation
Authors: Castellote Juan M. , Kofler Markus , Mayr Andreas , Saltuari Leopold
Published: February 2017

Passive limb displacement is routinely used to assess muscle tone. If we attempt to quantify muscle stiffness using mechanical devices, it is important to know whether kinematic stimuli are able to trigger startle reactions. Whether kinematic stimuli are able to elicit a startle reflex and to accelerate prepared voluntary movements (StartReact effect) has not been studied extensively to date. Eleven healthy subjects were suspended in an exoskeleton and were exposed to passive left knee flexion (KF) at three intensities, occasionally replaced by fast right KF. Upon perceiving the movement subjects were asked to perform right wrist extension (WE), assessed by extensor carpi radialis (ECR) electromyographic activity. ECR latencies were shortest in fast trials. Startle responses were present in most fast trials, yet being significantly accelerated and larger with right versus left KF, since the former occurred less frequently and thus less expectedly. Startle responses were associated with earlier and larger ECR responses (StartReact effect), with the largest effect again upon right KF. The results provide evidence that kinematic stimuli are able to elicit both startle reflexes and a StartReact effect, which depend on stimulus intensity and anticipation, as well as on the subjects’ preparedness to respond.
Energy Efficient Clustering Based Network Protocol Stack for 3D Airborne Monitoring System
Authors: Joshi Abhishek , Dhongdi Sarang , Sethunathan Rishabh , Nahar Pritish , Anupama K. R.
Published: February 2017

Wireless Sensor Network consists of large number of nodes densely deployed in ad hoc manner. Usually, most of the application areas of WSNs require two-dimensional (2D) topology. Various emerging application areas such as airborne networks and underwater wireless sensor networks are usually deployed using three-dimensional (3D) network topology. In this paper, a static 3D cluster-based network topology has been proposed for airborne networks. A network protocol stack consisting of various protocols such as TDMA MAC and dynamic routing along with services such as time synchronization, Cluster Head rotation, and power level management has been proposed for this airborne network. The proposed protocol stack has been implemented on the hardware platform consisting of number of TelosB nodes. This 3D airborne network architecture can be used to measure Air Quality Index (AQI) in an area. Various parameters of network such as energy consumption, Cluster Head rotation, time synchronization, and Packet Delivery Ratio (PDR) have been analyzed. Detailed description of the implementation of the protocol stack along with results of implementation has been provided in this paper.
Effect of Zirconia Dental Implant Surfaces on Bone Integration: A Systematic Review and Meta-Analysis
Authors: Hafezeqoran Ali , Koodaryan Roodabeh
Published: February 2017

Background. The information available about osseointegration and the bone to implant interaction of zirconia implants with various surface modifications is still far from sufficient.Objective. The purpose of this systematic review and meta-analysis was to evaluate and compare zirconia dental implants with different surface topographies, with a focus on bone to implant contact and removal torque.Methods. The systematic review of the extracted publications was performed to compare the bone to implant contact (BIC) with removal torque (RT) values of titanium dental implants and machined and surfaced modified zirconia implants.Results. A total of fifteen articles on BIC and RT values were included in the quantitative analysis. No significant difference in the BIC values was observed between titanium and machined zirconia implants (p=0.373; 95% CI:-0.166 to 0.443). However, a significantly better BIC values were observed for acid etched zirconia implants compared with those of titanium implants (p=0.032; 95% CI: 0.068 to 1.461). Unmodified zirconia implants showed favorable BIC values compared to modified-surface zirconia implants (p=0.021; 95% CI:-0.973 to-0.080).Conclusion. Acid etched zirconia implants may serve as a possible substitute for successful osseointegration.
Cost Analysis of a Novel Enzymatic Debriding Agent for Management of Burn Wounds
Authors: Giudice Giuseppe , Filoni Angela , Maggio Giulio , Bonamonte Domenico , Vestita Michelangelo
Published: February 2017

Introduction. Given its efficacy and safety, NexoBrid™ (NXB) has become part of our therapeutic options in burns treatment with satisfactory results. However, no cost analysis comparing NXB to the standard of care (SOC) has been carried out as of today. Aim. To assess the cost of treatment with NXB and compare it to the SOC cost. Methods. 20 patients with 14–22% of TBSA with an intermediate-deep thermal burn related injury were retrospectively and consecutively included. 10 of these patients were treated with the SOC, while the other 10 with NXB. The cost analysis was performed in accordance with the weighted average Italian Health Ministry DRGs and with Conferenza Stato/Regioni 2003 and the study by Tan et al. For each cost, 95% confidence intervals have been evaluated. Results. Considering the 10 patients treated with NXB, the overall savings (total net saving) amounted to 53300 euros. The confidence interval analysis confirmed the savings. Discussion. As shown by our preliminary results, significant savings are obtained with the use of NXB. The limit of our study is that it is based on Italian health care costs and assesses a relative small cohort of patients. Further studies on larger multinational cohorts are warranted.