bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety Aspects of Herb Interactions: Current Understanding and Future
Prospects
Authors: Hazra Subhajit , Singh Preet Amol
Published: March 2024

Background:

The use of herbal medicines is on the rise throughout the world due to their perceived
safety profile. However, incidences of herb-drug, herb-herb and herb-food interactions considering safety aspects
have opened new arenas for discussion.

Objective:

The current study aims to provide comprehensive insights into the various types of herb interactions,
the mechanisms involved, their assessment, and historical developments, keeping herbal safety at the
central point of discussion.

Methods:

The authors undertook a focused/targeted literature review and collected data from various databases,
including Science Direct, Wiley Online Library, Springer, PubMed, and Google Scholar. Conventional literature
on herbal remedies, such as those by the WHO and other international or national organizations.

Results:

The article considered reviewing the regulations, interaction mechanisms, and detection of herb-herb,
herb-drug and herb-food interactions in commonly used yet vital plants, including Glycyrrhiza glabra, Mentha
piperita, Aloe barbadensis, Zingiber officinale, Gingko biloba, Withania somnifera, etc. The study found that
healthcare professionals worry about patients not informing them about their herbal prescriptions (primarily
used with conventional treatment), which can cause herb-drug/herb-food/herb-herb interactions. These interactions
were caused by altered pharmacodynamic and pharmacokinetic processes, which might be explained using
in-vivo, in-vitro, in-silico, pharmacogenomics, and pharmacogenetics. Nutrivigilance may be the greatest
method to monitor herb-food interactions, but its adoption is limited worldwide.

Conclusion:

This article can serve as a lead for clinicians, guiding them regarding herb-drug, herb-food, and
herb-herb interactions induced by commonly consumed plant species. Patients may also be counseled to avoid
conventional drugs, botanicals, and foods with a restricted therapeutic window.
A Combination of Pharmacophore Generation, Ligand-based Virtual Screening, Atom-based 3D-QSAR, and Molecular Docking Studies on Febuxostat-based Amides Analogues as Anti-inflammatory Agents
Authors: Chitre Trupti S. , Bhatambrekar Aniket L. , Hirode Purvaj V. , Thorat Shubhangi B. , Hajare Sayli G. , Garud Dinesh R. , Jagdale Sakshi M. , Asgaonkar Kalyani D.
Published: March 2024

Background:

A defence mechanism of the body includes inflammation. It is a process
through which the immune system identifies, rejects, and starts to repair foreign and damaging stimuli.
In the world, chronic inflammatory disorders are the leading cause of death.

Materials and Methods:

To obtain optimized pharmacophore, previously reported febuxostat-
based anti-inflammatory amide derivatives series were subjected to pharmacophore hypothesis,
ligand-based virtual screening, and 3D-QSAR studies in the present work using Schrodinger
suite 2022-4. QuikProp module of Schrodinger was used for ADMET prediction, and HTVS, SP,
and XP protocols of GLIDE modules were used for molecular docking on target protein (PDB
ID:3LN1).

Result:

Utilising 29 compounds, a five-point model of common pharmacophore hypotheses was
created, having pIC50 ranging between 5.34 and 4.871. The top pharmacophore hypothesis AHHRR_
1 model consists of one hydrogen bond acceptor, two hydrophobic groups and two ring substitution
features. The hypothesis model AHHRR_1 underwent ligand-based virtual screening using
the molecules from Asinex. Additionally, a 3D-QSAR study based on individual atoms was performed
to assess their contributions to model development. The top QSAR model was chosen
based on the values of R2 (0.9531) and Q2 (0.9424). Finally, four potential hits were obtained by
molecular docking based on virtual screening.

Conclusion:

The virtual screen compounds have shown similar docking interaction with amino
acid residues as shown by standard diclofenac sodium drugs. Therefore, the findings in the present
study can be explored in the development of potent anti-inflammatory agents.
The Emerging Role of Polyethylene Glycol-Water (PEG-H2O) as the Benign Mixed Solvent System in Organic Synthesis
Authors: Divyavani Chitteti , Padmaja Pannala , Narayana Reddy Pedavenkatagari
Published: March 2024

:

Polyethylene glycol (PEG) has become a popular solvent and green catalyst for a variety
of chemical reactions. It is a stable and biodegradable polymeric catalyst used in organic synthesis
because it may be recycled numerous times without significantly losing its catalytic activity. Recently,
the use of PEG-H2O mixed solvent systems in organic synthesis has gained popularity.

:

This article presents an overview of PEG-H2O solvent system-mediated organic reactions, with a
main focus on the importance of the solvent system. The study also focuses on recent developments
in the PEG-H2O solvent system-mediated synthesis of a number of heterocyclic compounds

:

Important characteristics of these PEG-H2O solvent systems include high atom economies, gentle
reaction conditions, faster reaction rates, readily isolated side products and high yields. Results
from various reactions showed that the choice of proper ratio of PEG: H2O solvent system plays a
key role in product yields.
Quercetin Enhances 5-fluorouracil Sensitivity by Regulating the Autophagic
Flux and Inducing Drp-1 Mediated Mitochondrial Fragmentation in Colorectal
Cancer Cells
Authors: Li Mei , Fan Jiaoxiu , Hu Min , Xu Junyu , He Ziyue , Zeng Jun
Published: March 2024

Background::

While chemotherapy treatment demonstrates its initial effectiveness in eliminating the majority of the tumor cell population, nevertheless, most
patients relapse and eventually succumb to the disease upon its recurrence. One promising approach is to explore novel, effective chemotherapeutic
adjuvants to enhance the sensitivity of cancer cells to conventional chemotherapeutic agents. In the present study, we explored the effect of
quercetin on the sensitivity of colorectal cancer (CRC) cells to conventional chemotherapeutic agent 5-fluorouracil (5-FU) and the molecular
mechanisms.

Methods::

MTT assay, colony formation assay and Hoechst staining were performed to investigate the growth inhibition effect of quercetin alone or
combined with 5-FU. The expression levels of apoptosis- and autophagy-related proteins were assessed by western blotting. Intracellular ROS was
detected using DCFH-DA. The change in the mitochondrial membrane potential was measured by a JC-1 probe. The effect of quercetin on
mitochondrial morphology was examined using a mitochondrial-specific fluorescence probe, Mito-Tracker red.

Results::

The results demonstrated quercetin-induced apoptosis and autophagy, as well as imbalanced ROS, decreased mitochondrial membrane potential,
and Drp-1-mediated mitochondrial fission in CRC cells. Autophagy blockage with autophagy inhibitor chloroquine (CQ) enhanced quercetininduced
cytotoxicity, indicating that quercetin-induced cytoprotective autophagy. Meanwhile, quercetin enhanced the sensitivity of CRC cells to 5-
FU via the induction of mitochondrial fragmentation, which could be further enhanced when the quercetin-induced protective autophagy was
blocked by CQ.

Conclusion::

Our findings suggested that quercetin could induce protective autophagy and Drp-1-mediated mitochondrial fragmentation and enhance the
sensitivity of CRC cells to conventional agent 5-FU, which not only suggests that quercetin may act as a chemotherapeutic adjuvant but also
implies that the regulation of autophagic flux may be a potential therapeutic strategy for colorectal cancer.
Peningkatan Peranan Desa dalam Perluasan Jangkauan Layanan Pendidikan dan Kesehatan: Studi Kasus Desa Saptorenggo, Kecamatan Pakis, Kabupaten Malang
Authors:   Departemen Ilmu Ekonomi, Fakultas Ekonomi dan Bisnis, Universitas Brawijaya, Santoso Dwi Budi
Published: March 2024

Desa Saptorenggo masih dihadapkan persoalan rendahnya jangkauan akses layanan pendidikan dan kesehatan. Dengan berfokus pada aspek pembiayaan, kegiatan ini bertujuan memberikan pendampingan kepada perangkat Desa Saptorenggo dalam: i) peningkatan ketepatan penentuan prioritas program yang dibiayai melalui APBDes; dan ii) peningkatan kemampuan memperoleh sumber pembiayaan alternatif yang berasal dari Dana Corporate Social Responsibility (CSR) dan Dana Sosial. Untuk mencapai tujuan kegiatan, peneliti menggunakan metode participatory rural appraisal (PRA). Dalam kegiatan ini, peningkatan ketepatan penentuan prioritas program pendidikan dan kesehatan melalui APBDes dilakukan dengan memetakan program yang selaras dengan fokus pembangunan nasional (cross-cutting issues) dan pemutakhiran basis data kependudukan yang dijadikan sebagai dasar penentuan kelompok penerima manfaat. Sedangkan, peningkatan kemampuan memperoleh sumber pembiayaan alternatif dilakukan dengan mengidentifikasi program pendidikan dan kesehatan yang sesuai dengan kepentingan perusahaan dan NGO.
Application of packaging technology to improve the quality of strawberry milk in Tulungrejo Village, Batu
Authors:   Fakultas Teknologi Pertanian, Universitas Brawijaya, Sugiarto Yusron
Published: March 2024

This program targets unproductive Micro, Small and Medium-sized Enterprises (MSMEs) farmer groups in Dusun Wonorejo, Desa Tulungrejo, Kecamatan Bumiaji. The program deals with problems related to the cultivation of strawberries, the production of strawberry jelly drinks, and business permits. The activities during the community services were 1) the assistance for strawberry farmers to enhance the cultivation of strawberries; 2) the socialization activities related to product strengthening by packaging technology; and 3) the guidance on obtaining business permits. This community service implemented an integrated approach to enhance the creativity and knowledge of strawberry farmer groups to increase the economic value of processed strawberry products. The community service activities provided strawberry plant seedlings for rejuvenation, enabling partners to independently manage and develop strawberry-picking tourism. During socialization activities, the farmer gains an understanding of the necessary business permits. Any spelling, grammar, and punctuation errors have been corrected. Furthermore, the socialization of packaging helped farmers to improve packaging to enhance product quality.
Utilization of Podcasts as Supporting Media for the Digitalization of Kumkm-Tangguh Schools in Batu City
Authors:   Fakultas Teknologi Pertanian, Universitas Brawijaya,, Mustaniroh Siti Asmaul
Published: March 2024

Program Sekolah KUMKM-Tangguh adalah program pendampingan dan pelatihan yang merupakan salah satu layanan yang ditawarkan oleh PLUT-KUMKM Kota Batu. Namun, manfaat program ini belum dapat dirasakan oleh KUMKM secara luas. Upaya digitalisasi dengan memanfaatkan platform digital diharapkan mampu memperluas jangkauan Sekolah KUMKM-Tangguh. Tim MF Universtias Brawijaya berperan proaktif dalam inisiasi dan pendampingan kegiatan Digitalisasi Sekolah KUMKM Tangguh. Tujuan dari kegiatan ini adalah untuk melakukan analisis keperluan kegiatan Digitalisasi Sekolah KUMKM-Tangguh Kota Batu, melakukan pengadaan sarana pengembangan podcast dan pendampingan pengembangan konten podcast. Kegiatan dilaksanakan selama 6 bulan, yang terdiri dari 4 tahap, yaitu survei KUMKM, pengadaan alat podcast, pelaksanaan pembuatan podcast dan evaluasi kegiatan. Berdasarkan hasil survei KUMKM, tim MF menyusun rencana kegiatan dan konten digital; melaksanakan pengadaan peralatan podcast dan melakukan pendampingan pengembangan konten podcast. Evaluasi kegiatan dilaksanakan di akhir kegiatan berdasarkan jumlah viewer dan like pada video podcast yang diunggah pada YouTube.
Application of Retort Pouch Sterilization Technology to DD Satoe Packaged Chili Sauce Surabaya
Authors:   Fakultas Teknologi Pertanian, UniversitasBrawijaya, Ali Dego Yusa
Published: March 2024

People in Indonesia are usually consuming commercial packaged of home-made chili sauce, which is mostly produced by MSMEs. UD Dede Satoe produce chili sauce using preservation techniques with aseptic packaging. The weakness of this technique is that aseptic conditions are not fully adequate for preservation. Nowadays, people awareness to health and food safety are increasing. To meet market demand for packaged chili products without preservatives addition, UD DD Satoe is trying to change the process from aseptic packaging to sterilizing packaged chili sauce using retort technology. The evaluation results show that retort pouch sambal can last for 1 year without the addition of preservatives. This result was proven to be better than the preservation method of making semi-dry packaged chili sauce, because it can maintain the color, taste and texture of the chili sauce.
Jorge Tadeo Lozano en la Real Expedición Botánica del Nuevo Reino de Granada
Authors:   Universidad de Bogotá Jorge Tadeo Lozano, Colombia, Molano Alejandro
Published: March 2024

Lozano se unió oficialmente a la Expedición Botánica el 23 de enero de 1803 como zoólogo agregado, pero su vínculo con el círculo de los ilustrados neogranadinos comenzó en sus años de formación en filosofía en el Colegio del Rosario. La organización de la Expedición Botánica por el virrey Antonio Caballero y Góngora en 1783 fue todo un acontecimiento seguido con mucho interés por profesores y estudiantes del Rosario, Jorge Tadeo entre ellos. Este volumen explora algunos de los aportes de Lozano a la Real Expedición Botánica, en particular los de su obra Fauna cundinamarquesa.
Complete ocular tilt reaction with subjective visual vertical tilt in a patient with a medial prefrontal cortex lesion: a case report
Authors: Lee Hyung , Kim Hyun Ah
Published: March 2024

A 61-year-old male patient undergoing chemotherapy for esophageal cancer presented with symptoms of rightward tilting while both sitting and walking. A neurological examination revealed a head tilt, skew deviation with hypertrophy of the left eye, and a rightward shift in his gait. No spontaneous nystagmus was observed, and the vestibulo-ocular reflex was normal. Magnetic resonance imaging of the head revealed a suspected metastatic lesion in the right medial prefrontal cortex. Following the initiation of levetiracetam treatment, the patient demonstrated marked improvement, with the resolution of both head tilt and skew deviation within 1 month. Traditionally, the ocular tilt reaction has been attributed to unilateral or asymmetric dysfunction of the graviceptive pathways extending from the utricle to the upper midbrain lesions. However, this case highlights the potential involvement of the prefrontal cortex in the ocular tilt reaction. Further research is warranted on the role of the prefrontal cortex within the vestibular system.
Map-aiding of the additional secondary factors isosurface by the spline approximation method as a condition of improving the e-Loran observations accuracy
Authors: Yuyukin I. V.
Published: March 2024

The benefit of the Loran ground-based radio navigation system as an alternative to global navigation satellite systems is argued. The motivation of searching for a duplicate variant is caused by the necessity to ensure the reliability of positioning as a subject of countering spoofing and jamming risks when implementing the concept of cybernetic awareness on water transport. Hypothetically, the possibility of using e-Loran on the Northern Sea Route as a backup navigation system is considered. The experience of operating pilot projects of the enhanced Loran in the issue of the predicted potential of positioning accuracy is analyzed. The optimal method of compensation for the system error of geolocation based on the use of additional secondary factors is investigated. Taking into account the principle of the d-Loran functional, based on comparing the measured values of the radio signal passage delay with published analogues for transmitting clarifications to marine consumers, the necessity of using integrity as a criterion for a confidence assessment of the navigation information processing reliability has been determined. A critical analysis of the attempts effectiveness to use the linear interpolation method to calculate intermediate representative values of the delay in the radio signal transmission in order to simulate the map of additional secondary factors is performed. The hypothesis of the prospects for the isosurface corrections synthesis based on B-spline approximation is put forward. The South Korean experiment of synthesizing a chart of additional secondary factors with measured indicators of the radio signal propagation time delay in nanoseconds from the Pohang transmitting station has been repeated at the correct algorithmic level. In order to demonstrate the practical feasibility of the spline algorithm, a computer visualization of a cartographic fragment of additional secondary factors of Yongil Bay is performed. It is suggested that three-dimensional representation of the additional secondary factor for situational perception by the Officer on watch of map-aided correction as a process in alternative positioning in order to increase the reliability of location control through visual evaluation of proper use of corrections of the e-Loran differential variant. The prospect of using the developed package of applied Pascal-programs with implementations on display-type monitors as intellectual support for decision-making by the navigator in a posteriori assessment of the observation accuracy due to the visual representation of the correction field is noted.
Corpoica Andina :variedad de uchuva para Boyacá, Cundinamarca, Antioquia y Nariño
Authors: Núñez Zarantes Víctor Manuel , Sánchez Betancourt Erika Patricia , Mayorga Cubillos Franklin Giovanny , Gómez Gil Luis Fernando , Navas Arboleda Alejandro Alberto
Published: March 2024

El cultivo de la uchuva (Physolis peruviana L., Solanaceae) se encuentra distribuido en las zonas altas de la región Andina. Según Legge (1974) su origen se ubica en la zona andina de Perú; sin embargo, es posible que el fruto haya llegado de Brasil y se haya aclimatado en las áreas de Perú y Chile (CRFG 1997). Colombia inició cultivos en los años ochenta y hoy día es el primer productor mundial. Actualmente, se cultiva en siete departamentos con un área de producción de alrededor de 932 hectáreas, una producción total de 13.260 t y un rendimiento promedio de 9,81 t/ ha. Las mayores áreas de siembra se encuentran en Boyacá (409 ha), Antioquia (191 ha) y Cundinamarca (150 ha). Es un cultivo huérfano en el que los productores dependen de material de siembra de viveros sin ninguna identificación genética, y no de cultivares registrados y certificados.
Views of Specialist Clinicians and People With Multiple Sclerosis on Upper Limb Impairment and the Potential Role of Virtual Reality in the Rehabilitation of the Upper Limb in Multiple Sclerosis: Focus Group Study
Authors: Webster Amy , Poyade Matthieu , Coulter Elaine , Forrest Lisa , Paul Lorna
Published: March 2024

Background

Finding enjoyable and effective long-term approaches to rehabilitation for improving the upper limb (UL) function of people with multiple sclerosis (MS) is challenging. Using virtual reality (VR) could be a solution to this challenge; however, there is a lack of reporting on the views of people with MS and clinicians on VR-based approaches and recommendations for games for rehabilitation.

Objective

This study aims to identify common UL problems and their related current therapeutic approaches for people with MS, and to explore the opinions of people with MS and specialist clinicians on VR and obtain suggestions for the development and design of VR games.

Methods

Separate focus groups were conducted with people with MS, recruited through the MS Society UK’s research network, and clinicians, recruited through the MS Trust Therapists in MS network. A total of 10 people with MS (2 focus groups) and 8 clinicians (5 physiotherapists, 2 occupational therapists, and 1 MS nurse in 2 focus groups) were involved. The focus groups were recorded and transcriptions were analyzed using theme-based content analysis.

Results

People with MS commonly reported that their UL problems interfered with activities of daily living and resulted in the loss of meaningful hobbies such as writing. Many people with MS neglected UL exercise and found strategies for adapting to the UL impairments. Similarly, clinicians stated UL rehabilitation was neglected within their service and that it was challenging to find interesting treatment strategies. VR was suggested by both participant groups as a solution, as it was convenient for people with MS to access and it could provide a more engaging and disguised approach to exercise. There were shared concerns with cybersickness and disengagement with using VR approaches. Both groups agreed games should be meaningful and adaptable for users but suggested different VR activities, with clinicians suggesting games directly reflecting activities of daily living and people with MS suggesting more abstract activities.

Conclusions

VR was well received by both people with MS and clinicians for UL rehabilitation. Recommendations were made for the development of VR rehabilitation games which are personalized and customizable for the varying abilities of people with MS.
New Approach to Equitable Intervention Planning to Improve Engagement and Outcomes in a Digital Health Program: Simulation Study
Authors: Killian Jackson A , Jain Manish , Jia Yugang , Amar Jonathan , Huang Erich , Tambe Milind
Published: March 2024

Background

Digital health programs provide individualized support to patients with chronic diseases and their effectiveness is measured by the extent to which patients achieve target individual clinical outcomes and the program’s ability to sustain patient engagement. However, patient dropout and inequitable intervention delivery strategies, which may unintentionally penalize certain patient subgroups, represent challenges to maximizing effectiveness. Therefore, methodologies that optimize the balance between success factors (achievement of target clinical outcomes and sustained engagement) equitably would be desirable, particularly when there are resource constraints.

Objective

Our objectives were to propose a model for digital health program resource management that accounts jointly for the interaction between individual clinical outcomes and patient engagement, ensures equitable allocation as well as allows for capacity planning, and conducts extensive simulations using publicly available data on type 2 diabetes, a chronic disease.

Methods

We propose a restless multiarmed bandit (RMAB) model to plan interventions that jointly optimize long-term engagement and individual clinical outcomes (in this case measured as the achievement of target healthy glucose levels). To mitigate the tendency of RMAB to achieve good aggregate performance by exacerbating disparities between groups, we propose new equitable objectives for RMAB and apply bilevel optimization algorithms to solve them. We formulated a model for the joint evolution of patient engagement and individual clinical outcome trajectory to capture the key dynamics of interest in digital chronic disease management programs.

Results

In simulation exercises, our optimized intervention policies lead to up to 10% more patients reaching healthy glucose levels after 12 months, with a 10% reduction in dropout compared to standard-of-care baselines. Further, our new equitable policies reduce the mean absolute difference of engagement and health outcomes across 6 demographic groups by up to 85% compared to the state-of-the-art.

Conclusions

Planning digital health interventions with individual clinical outcome objectives and long-term engagement dynamics as considerations can be both feasible and effective. We propose using an RMAB sequential decision-making framework, which may offer additional capabilities in capacity planning as well. The integration of an equitable RMAB algorithm further enhances the potential for reaching equitable solutions. This approach provides program designers with the flexibility to switch between different priorities and balance trade-offs across various objectives according to their preferences.
Pharmacy Students’ Attitudes Toward Distance Learning After the COVID-19 Pandemic: Cross-Sectional Study From Saudi Arabia (Preprint)
Authors: Alsahali Saud , Almutairi Salman , Almutairi Salem , Almofadhi Saleh , Anaam Mohammed , Alshammari Mohammed , Abdulsalim Suhaj , Almogbel Yasser
Published: March 2024

BACKGROUND

Electronic learning refers to the use of assistive tools in offline and distance learning environments. It allows students to access learning tools and materials anytime and anywhere. However, distance learning courses depend on several factors that affect the quality of learning, which consequently affect students’ preferences in the settings and tools used to deliver educational materials.

OBJECTIVE

This study aimed to evaluate students’ preferences for continuing distance learning after the pandemic and to assess the distance educational environment after the pandemic. It also aimed to identify the factors affecting distance learning and evaluate students’ preferences regarding modes of communication with instructors.

METHODS

A web-based survey was used to conduct this cross-sectional study. The target participants of this study were students in the doctor of pharmacy program at Unaizah College of Pharmacy, Qassim, Saudi Arabia. All students enrolled from December 2022 to January 2023 received an invitation with a link to the web-based survey.

RESULTS

The survey was completed by 141 students (58 female students and 83 male students). The research results showed that most students (102/141, 72.3%) did not wish to continue distance education for laboratory courses, and 60.3% (85/141) did not wish to continue taking distance team-based learning after the pandemic. Additionally, 83.7% (118/141) of the students indicated that distance courses were simple. More than half of the participants (79/141, 56%) stated that having a camera on during class negatively impacted their learning, and only 29.1% (41/141) of the students stated that nonvisual communication with their fellow students impacted their learning. A large proportion of students (83/141, 58.9%) reported impairment of social engagement on campus, 44% (62/141) in-person interactions during classes, and 73.7% (104/141) were relieved that their classes were not disrupted.

CONCLUSIONS

Similar to all types of education, distance learning is characterized by advantages and disadvantages, as reported by students. Students felt that the course material was intelligible, and the distance course was uncomplicated. Moreover, they expressed relief that their studies were not disrupted. However, they also reported the loss of face-to-face contact during courses as the most significant drawback of distance learning versus face-to-face learning, followed by a lack of social connection on campus.
Personalized and Culturally Tailored Features of Mobile Apps for Gestational Diabetes Mellitus and Their Impact on Patient Self-Management: Scoping Review (Preprint)
Authors: Jones Catherine , Cui Yi , Jeminiwa Ruth , Bajracharya Elina , Chang Katie , Ma Tony
Published: March 2024

BACKGROUND

Gestational diabetes mellitus (GDM) is an increasingly common high-risk pregnancy condition requiring intensive daily self-management, placing the burden of care directly on the patient. Understanding personal and cultural differences among patients is critical for delivering optimal support for GDM self-management, particularly in high-risk populations. Although mobile apps for GDM self-management are being used, limited research has been done on the personalized and culturally tailored features of these apps and their impact on patient self-management.

OBJECTIVE

This scoping review aims 1) to determine the extent to which GDM mobile apps used in published studies provide personalized and culturally tailored features for self-management support for patients, and 2) to assess the impact of these GDM mobile apps with personalized and culturally tailored features on patient self-management.

METHODS

We examined English-language peer-reviewed articles published between October 2016 and May 2023 from PubMed, CINAHL, PsycINFO, ClinicalTrials.gov, Proquest Research Library, and Google Scholar using search terms related to digital tools, diabetes, pregnancy, and cultural tailoring. We reviewed eligible articles and extracted data using the Arskey and O’Malley methodological framework.

RESULTS

Our search yielded a total of 1772 articles after the removal of duplicates and 158 articles for full-text review. A total of 21 articles that researched 15 GDM mobile apps were selected for data extraction. Our results demonstrated the stark contrast between the number of GDM mobile apps with personalized features for the individual user (all 15 mobile apps) and those culturally tailored for a specific population (only 3 of the 15 mobile apps). Our findings showed that GDM mobile apps with personalized and culturally tailored features were perceived to be useful to patients and had the potential to improve patients’ adherence to glycemic control and nutrition plans.

CONCLUSIONS

There is a strong need for increased research and development to foster the implementation of personalized and culturally tailored features in GDM mobile apps for self-management designed for patients from diverse backgrounds and ethnicities. Personalized and culturally tailored features have the potential to serve the unique needs of patients more efficiently and effectively than generic features alone, however their impacts still need to be adequately studied. Recommendations for future research include examining the cultural needs of different ethnicities in the context of GDM self-management, particularly in the increasingly diverse United States population, conducting participatory-based research with these groups, and designing human-centered mHealth solutions for both patients and providers.
KDIGO 2024 Clinical Practice Guideline for the Management of Lupus Nephritis
Authors: Authors No
Published: March 2024

No abstract
Hemodialysis as a treatment option for chronic kidney disease in Ekiti State University Teaching Hospital: a retrospective study
Authors: Ibitoba Funmilayo A. , Akpor Oluwaseyi A. , Ogunkorode Agatha O. , Bello Aderemi Y. , Ogunyemi Omotomilola O.
Published: March 2024

The prevalence of chronic kidney disease (CKD) has surged to approximately 13 % in the past two decades due to an increase in associated risk factors. Poorly managed CKD can progress to end-stage renal disease, necessitating renal replacement therapy, with hemodialysis being the most common form. This study examines a 5-year record of hemodialysis in a healthcare facility in southwest Nigeria. Study data were collected from dialysis register and case study of patients that were consecutively dialyzed at the dialysis centre of Ekiti State University Teaching Hospital between January 2017 and December 2021. Unstructured proforma was used to extract data for the study. There was a total of 152 patients and 1600 hemodialysis sessions between January 2017 and December 2021. More than a quarter of the patients were civil servants and there were more males than females (p = 0.3325). CKD was the major indication for hemodialysis with hypertension as its main cause while post-partum hemorrhage was the most common cause of acute kidney injury. Only 3.3 % of the patients had permanent access of arteriovenous fistula. Notably, 47.2 % of the patients were lost to follow-up, 29.8 % left to other centres by either referral or self-decision, while 18.6 % died of CKD-related complications. Nevertheless, 4.4 % patients were still dialyzing in the Centre as of December 2021. Comparatively fewer hemodialysis sessions occurred, yet they led to improved patient outcomes. Regular follow-ups and government subsidies are recommended to ease patient burdens.
A Cost-Benefit Analysis of Mandatory and Voluntary Corporate Disclosure
Authors: Zhao Yiming
Published: March 2024

Disclosure is important for corporate financing and business activities, as explained by Signalling Theory and Principal-Agent Theory. Corporate disclosure can be divided into voluntary and mandatory. Driven by the pursuit of maximising economic benefits, companies are motivated to opt to disclose voluntarily, notwithstanding the self-interest of managers and the dilemma of free-riding reduces the incentives and role of such disclosures. This inherent limitation of voluntary disclosure mechanisms has catalysed the widespread adoption of mandatory disclosure requirements. However, a simplistic discussion of the advantages and disadvantages of voluntary versus mandatory falls short of providing a conclusion. To address this gap, this study incorporates a cost-benefit analysis framework from law and economics. The effectiveness of mandatory disclosure, conceptualized as a form of governmental intervention in economic activities, hinges on the balance between its implementation costs and the derived benefits. The value of mandatory disclosure is related to regulatory effectiveness, which in turn influences the costs borne by companies in meeting disclosure requirements and the challenges faced by investors in utilising disclosed information.
Financial Literacy Among the Senior High School Students: Basis for Financial Stewardship Plan
Authors: V. Gabay Paul John , G. Bagsic Aleyah Eden , E. Beri John Caezzer , J. Lauresta Clarish , M. Vetuz Monaliza
Published: March 2024

This study investigated the financial literacy of senior high school students, exploring their ability to make informed financial decisions and navigate money management challenges. The researchers also assessed the financial knowledge, behaviors, and the most common difficulties that the students encountered. The study aimed to identify potential areas in which future financial education initiatives could offer significant assistance in preparing young individuals for financial security. The data from this study were gathered from selected senior high school students using a self-administered questionnaire featuring a Likert-scale checklist, inspired by National Center for Education Statistics (NCES) questionnaires and all other subsequent analyses using descriptive statistics. The findings revealed that parents were the primary source of financial knowledge.Also, students faced challenges in money management and showed limited familiarity with financial terms, particularly budgeting. Therefore, the findings suggested a moderate to high level of financial literacy among senior high school students, emphasizing the need for a financial stewardship plan.
О достижимости целей действующей Концепции технологического развития
Authors: Кошкарева О.А.
Published: March 2024

Институте проблем развития науки Российской академии наук (ИПРАН РАН), Москва, Россия
В работе дан краткий обзор Концепции технологического развития Российской Федерации до 2030 года. Рассмотрена структура, принципы и цели, описанные в Концепции. Рассмотрены предложенные показатели достижения заявленных целей, сделаны выводы об их достижимости и репрезентативности. Даны определения деградирующих и отрицательных инноваций. Сделаны выводы о сильных и слабых сторонах Концепции, предложены пути корректирования слабых сторон.
The effectiveness of the algorithm Stroke Gadjah Mada’s (ASGM) and Guy's Hospital Stroke Score (GHSS) in determining the type of etroke emergency in the emergency room of Dr. H. Moch Ansari Saleh hospital
Authors: Mohtar M. Sobirin , Tjomiadi Cynthia Eka F , Jamilah Siti , Apriannor Ahmad
Published: March 2024

Introduction: Good stroke management depends on the speed and accuracy of the assessment system in diagnosing the type of stroke, in order to reduce mortality and morbidity. CT scan is a tool to differentiate the type of stroke, determine the location of the lesion and determine the severity of the disease. However, this tool is expensive and not all areas have it and the procedure takes quite a long time. Nurses need a diagnostic tool in the form of a simple assessment system including the Gadjah Mada Stroke Algorithm (ASGM) and Guy's Hospital Stroke Score (GHSS) which are easy, valid, reliable assessment tools in determining the type of stroke and preventing delays. Objectives:  Analyzing the comparison of the ASGM and GHSS scoring systems in determining the type of stroke emergency in the Emergency room. Methods:  This research method is quantitative pre-experimental design (posttest only design). The population was all stroke patients in the emergency room with 30 samples and the collection technique was accidental sampling. As for the stages, each respondent undergoes an ASGM assessment which consists of 3 components and GHSS 9 components. The statistical test used is the Paired Sample T-test, then an accuracy test is carried out by looking at the level of sensitivity and specificity. Results:  Based on the results of the Paired Sample T-test, the Sig value. amounting to 0.000 <0.05, which means there is a significant difference between the ASGM and GHSS scoring systems in determining the type of emergency in stroke patients. The average difference in the duration of determining the type of emergency and nursing diagnosis in the assessment system and ASGM and GHSS is 7.6 minutes. Furthermore, it also shows lower data of 7,066 and upper data of 8,134. This shows that the duration range for determining the type of emergency using ASGM is around 7.1 – 8.1 minutes faster compared to GHSS. Based on the accuracy test, the ASGM sensitivity level is 86.66% and the specificity level is 96.66%, while the GHSS sensitivity level is 56.66% and the specificity level is 63.33%.This difference is thought to be due to ASGM having more specific assessment variables for the brain, so that detecting suspected types of stroke in the acute phase is more accurate compared to GHSS. Conclusions: The ASGM and GHSS assessment methods are effective in determining the type of emergency in stroke patients in the ERHowever, in terms of duration, determining the type of emergency and.
The Vital Role of Blood Transfusions during Pregnancy: A Comprehensive Review
Authors: Obeagu Emmanuel Ifeanyi , Obeagu Getrude Uzoma
Published: March 2024

Pregnancy is a remarkable yet complex physiological state that can be accompanied by various complications, including obstetric hemorrhage and severe anemia, which significantly affect maternal and fetal health. Blood transfusions serve as crucial interventions to manage these complications and mitigate potential risks. This comprehensive review synthesizes the pivotal role of blood transfusions during pregnancy, encompassing their indications, benefits, risks, and advancements in transfusion medicine. Exploring the multifaceted landscape of transfusions in addressing obstetric challenges, anemia, and other maternal conditions, this article underscores the paramount importance of timely and appropriate transfusion interventions to safeguard the health and well-being of both mother and child. Through an in-depth analysis of current knowledge and emerging trends, this review aims to provide a holistic understanding of the significance of blood transfusions in optimizing outcomes during pregnancy. Keywords: Blood Transfusions, Pregnancy, Maternal Health, Hemorrhage, Anemia, Obstetrics, Fetal Health, Transfusion Medicine
Más allá de los espacios físicos: La Psicología Ambiental como forjadora del bienestar social
Authors: Becerra-Ramírez J. Jesús
Published: March 2024

En el contexto actual, la Psicología se enfrenta a desafíos ambientales, sociales y económicos complejos, lo que la impulsa a evolucionar constantemente, sobre todo por la globalización y la diversidad cultural es necesaria una Psicología adaptable e innovadora. La Psicología Ambiental surge como estrategia clave para moldear un futuro equitativo y resiliente, explorando la interacción entre el entorno y el comportamiento humano. La influencia del entorno en la salud mental, así como el diseño de espacios en conexión con la naturaleza impactan la psicología individual y colectiva, abordando la crisis ambiental y su papel en la salud mental. Revelando cómo los espacios físicos afectan emociones, comportamientos y relaciones, promoviendo cohesión social y mejorando la calidad de vida, dando significado a los espacios y generando vínculos afectivos, convirtiéndose en una herramienta esencial para mejorar la habitabilidad de los espacios y construir ciudades menos contaminadas. Explorando tendencias emergentes en Psicología, la Psicología Digital, Neurociencia Aplicada y Psicología Ambiental se destacan como enfoques efectivos para abordar desafíos contemporáneos. La Psicología Ambiental influye en la sostenibilidad y equidad social, fortaleciendo la resiliencia comunitaria ante eventos extremos. En conclusión, la Psicología Ambiental se revela como una estrategia clave para abordar desafíos actuales y construir un futuro equitativo y resiliente. Integra principios ambientales en la toma de decisiones y diseño de políticas, creando entornos sostenibles que promueven la salud mental y la equidad social. La Psicología emerge como un agente proactivo en la construcción de un bienestar social duradero.
Perfiles de vinculación científico-tecnológica en universidades del conurbano bonaerense: una perspectiva comparada
Authors: Di Meglio Fernanda
Published: March 2024

En años recientes, la función de vinculación científico-tecnológica de las universidades se ha convertido en una herramienta sustancial para aportar al desarrollo económico y social de los territorios en donde se asientan, sin embargo, el estilo y forma de organización no es homogénea en la totalidad del entramado universitario. En general, los estudios en el campo se han centrado en aquellas que presentan un alto dinamismo respecto de sus vínculos con el medio productivo, creando un patrón de gestión institucional que no siempre se condice con las dinámicas y realidades de las universidades de menor tamaño o asentadas en contextos económicos desiguales. Frente a ello, el presente estudio tuvo como objetivo indagar sobre el perfil institucional que adquiere la política de vinculación científico-tecnológica en cuatro universidades de tamaño mediano asentadas en el conurbano bonaerense, instituciones muy poco exploradas por la bibliografía especializada. En términos metodológicos, la investigación se desarrolló a partir de un estudio de casos comparados privilegiando un abordaje cualitativo. En este marco, como resultado de la investigación se observó que las universidades estudiadas se alejan del modelo de vinculación tradicional asociado exclusivamente a las empresas, y desarrollan un perfil de vinculación más de tipo socioproductiva y territorial, determinando objetivos, programas y actores diversos con los que interactúa.
THE DEVELOPMENT OF READING PROCEDURAL TEXT LOCAL CULTURE-BASED MATERIAL AT MTS LABOR JAMBI
Authors: Volya Duti , Arif Nely
Published: March 2024

This study aims to develop speaking for general purposes teaching materials based on an inquiry-based learning approach in Jambi University English education study program. This inquiry-learning approach-based teaching material was developed to improve students' speaking skills based on the inquiry process. This research is also a form of implementing learning with a project based learning (PJBL) program for listening and speaking courses for general purposes. The subjects of this development research are students of the first semester of the English education study program for the 2020/2021 academic year. They took the Speaking for general purpose course which is offered in the first semester. This research uses a Research and Development approach. The approach used in this research uses three stages, namely the exploration stage which includes analyzing the needs for teaching materials, the prototype model development stage which includes designing the model and testing the model and the validation stage which includes expert validation. (Sukmadinata (2008). The data collected at the exportation stage is speaking for general purpose based on inquiry. The material made is a prototype speaking for general purpose based on inquiry-based learning. In developing the material, researchers use YouTube online as a teaching and learning medium. Developing activities and learning and their assessments as one of the manifestations of student-centered learning (student based learning). Researchers develop a class management system and monitor and evaluate learning. Researchers also reflect on the learning process associated with the results of case methods and project based learning with innovative development of solving a case, increasing student participation in analyzing cases and finding solutions collaboratively. In the case method model, the lecturer provides a description of a situation that requires the actors in the situation to take l certain decisions to solve a problem. Based on the information presented in the case, students choose alternative problem solving that is considered the most appropriate based on an understanding of the problem, analysis and comparison of available alternative solutions.
On the Problem of the Volyn Chronicle Stratification (Prince Roman’s Descendants in the Assessment of the 13th Century Scribes)
Authors:   Lomonosov Moscow State University, Pautkin Alexey A.
Published: March 2024

The Galicia-Volyn Chronicle reflected the actions of three generations of Romanoviches. The assessments by ancient Russian scribes of the actions of certain rulers are not accidental. They often indicate changes in the organization of chronicle work. In relation to the Volyn Chronicle of the second half of the 13th century, the figure of Lev Danilovich, who owned large landholdings after his father’s death, is indicative. His characterization is very contradictory. If in the Galician and the initial part of the Volyn Chronicle the prince appears in the positive light, then during the reign of his cousin Vladimir Vasilkovich in Vladimir Volynsky, Lev Danilovich and his son Yuri appear as absolutely negative figures, endowed with many unfavorable qualities. At the end of the Volyn Chronicle, an unexpected change in the assessment of Lev Danilovich is noticeable. The chronicler again assesses him positively and praises his actions. The data of chronicle personology testify to the consolidated nature of the Volyn Chronicle, which reflected several contradictory testimonies of scribes who served as their pen to several descendants of Roman Mstislavich. The final part of the Volyn Chronicle probably reflected fragments of the text created by the chronicler Mstislav Danilovich, who was interested in good relations with his older powerful brother.
The Fate of Spanish Folk Genres in the New World
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kofman Andrey F.
Published: March 2024

The article shows what transformation three Spanish folklore genres, transferred to the New World by streams of conquistadors and emigrants (romance, copla, and décima), underwent. The traditional Spanish monorim romance is virtually extinct; strophic novelistic romance remained latent for almost three centuries until it gave rise to the growth of Creole romance in the 19th century. The article considers the features of this genre, which are generally determined by its lyrical-epic nature, in contrast to the Spanish romance. The most productive and viable in the New World was copla, the most widespread form of the so-called “arte menor,” the art of small poetic forms. It has not changed at all formally. However, being an improvisational genre, especially susceptible to variability, it has accumulated new substantive elements. Based on a comparison of Spanish and American variants, the article demonstrates the processes of targeted variability and desymbolization and pays special attention to the formation of machista motifs. Décima, a complex stanza born in the bosom of Spanish literature, existed for a very short time in Spanish folklore. In the New World, it reappeared as a folklore genre, became an improvisation tool, applicable in competitions of folk poets, and significantly expanded its themes.