bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of a Brief Functional Analysis and Functional Communication Training Conducted Through Telehealth
Authors: Craig Emma A. , Dounavi Katerina , Ferguson Jenny
Published: August 2022

This study evaluates the effectiveness of a brief functional analysis and functional communication training conducted via telehealth. Three interventionist-child dyads took part in the study including one speech and language pathologist and two school teaching assistants, each working with one child with autism spectrum disorder. Interventionists were trained using didactic training to implement a brief functional analysis as well as synchronous coaching from a BCBA® to implement functional communication training. A multiple baseline across participants design was utilised to evaluate if interventionists could implement functional communication training to decrease challenging behaviours that included aggression, elopement and disruption. Sessions concluded earlier than planned due to school closures mandated by the COVID-19 outbreak for two of the three participants; however, existing data provide evidence that telehealth is a valid model for enabling clinicians to work in collaboration with school personnel to effectively deliver assessment and intervention procedures remotely via telehealth.
Numerical methods using two different approximations of space-filling curves for black-box global optimization
Authors: Sergeyev Yaroslav D. , Nasso Maria Chiara , Lera Daniela
Published: August 2022

In this paper, multi-dimensional global optimization problems are considered, where the objective function is supposed to be Lipschitz continuous, multiextremal, and without a known analytic expression. Two different approximations of Peano-Hilbert curve applied to reduce the problem to a univariate one satisfying the Hölder condition are discussed. The first of them, piecewise-linear approximation, is broadly used in global optimization and not only whereas the second one, non-univalent approximation, is less known. Multi-dimensional geometric algorithms employing these Peano curve approximations are introduced and their convergence conditions are established. Numerical experiments executed on 800 randomly generated test functions taken from the literature show a promising performance of algorithms employing Peano curve approximations w.r.t. their direct competitors.
Gestational Health Outcomes Among Pregnant Women in the United States by Level of Dairy Consumption and Quality of Diet, NHANES 2003–2016
Authors: Davis Benjamin J. K. , Bi Xiaoyu , Higgins Kelly A. , Scrafford Carolyn G.
Published: August 2022

Objectives

Diet is an important factor in gestational health. Many pregnant women have suboptimal diets and dairy foods are an excellent source of key nutrients. The aim of this work was to investigate the relationships between dairy consumption (cup equivalents/day) or diet quality assessed using the Healthy Eating Index-2015 and gestational diabetes mellitus (GDM) or gestational weight gain (GWG) among pregnant women in the United States (US).

Methods

Study populations were subsets of pregnant, non-lactating women (20–44 years) in the National Health and Nutrition Examination Surveys 2003–2016, which was approved by the National Center for Health Statistics Research Ethics Review Board. GDM and GWG were classified according to national guidelines. General characteristics were compared across categories of dietary variables. Adjusted regression models estimated associations between diet and GDM and GWG.

Results

No statistically significant linear associations between dairy consumption or diet quality and GDM or GWG were observed.

Conclusions for Practice

Future research should aim to address the limitations of the current cross-sectional analyses and further elucidate the underlying relationships between diet and gestational health.
Climate change and 2030 cooling demand in Ahmedabad, India: opportunities for expansion of renewable energy and cool roofs
Authors: Joshi Jaykumar , Magal Akhilesh , Limaye Vijay S. , Madan Prima , Jaiswal Anjali , Mavalankar Dileep , Knowlton Kim
Published: August 2022

Most of India’s current electricity demand is met by combustion of fossil fuels, particularly coal. But the country has embarked on a major expansion of renewable energy and aims for half of its electricity needs to be met by renewable sources by 2030. As climate change-driven temperature increases continue to threaten India’s population and drive increased demand for air conditioning, there is a need to estimate the local benefits of policies that increase renewable energy capacity and reduce cooling demand in buildings. We investigate the impacts of climate change-driven temperature increases, along with population and economic growth, on demand for electricity to cool buildings in the Indian city of Ahmedabad between 2018 and 2030. We estimate the share of energy demand met by coal-fired power plants versus renewable energy in 2030, and the cooling energy demand effects of expanded cool roof adaptation in the city. We find renewable energy capacity could increase from meeting 9% of cooling energy demand in 2018 to 45% in 2030. Our modeling indicates a near doubling in total electricity supply and a nearly threefold growth in cooling demand by 2030. Expansion of cool roofs to 20% of total roof area (associated with a 0.21 TWh reduction in cooling demand between 2018 and 2030) could more than offset the city’s climate change-driven 2030 increase in cooling demand (0.17 TWh/year). This study establishes a framework for linking climate, land cover, and energy models to help policymakers better prepare for growing cooling energy demand under a changing climate.
Effect of Epigallocatechin-3-gallate on Stress-Induced Depression in a Mouse Model: Role of Interleukin-1β and Brain-Derived Neurotrophic Factor
Authors: Abdelmeguid Nabila E. , Hammad Tasneem M. , Abdel-Moneim Ashraf M. , Salam Sherine Abdel
Published: August 2022

Epigallocatechin 3-gallate (EGCG) is a natural polyphenolic antioxidant in green tea leaves with well-known health-promoting properties. However, the influence of EGCG on a chronic animal model of depression remains to be fully investigated, and the details of the molecular and cellular changes are still unclear. Therefore, the present study aimed to investigate the antidepressant effect of EGCG in mice subjected to chronic unpredictable mild stress (CUMS). After eight consecutive weeks of CUMS, the mice were treated with EGCG (200 mg/kg b.w.) by oral gavage for two weeks. A forced swimming test (FST) was used to assess depressive symptoms. EGCG administration significantly alleviated CUMS-induced depression-like behavior in mice. EGCG also effectively decreased serum interleukin-1β (IL-1β) and increased the mRNA expression levels of brain-derived neurotrophic factor (BDNF) in the hippocampal CA3 region of CUMS mice. Furthermore, electron microscopic examination of CA3 neurons in CUMS mice showed morphological features of apoptosis, loss or disruption of the myelin sheath, and degenerating synapses. These neuronal injuries were diminished with the administration of EGCG. The treatment effect of EGCG in CUMS-induced behavioral alterations was comparable with that of clomipramine hydrochloride (Anafranil), a tricyclic antidepressant drug. In conclusion, our study demonstrates that the antidepressive action of EGCG involves downregulation of serum IL-1β, upregulation of BDNF mRNA in the hippocampus, and reduction of CA3 neuronal lesions.
Placebo administration for dry eye disease: a level I evidence based systematic review and meta-analysis
Authors: Prinz Julia , Maffulli Nicola , Fuest Matthias , Walter Peter , Hildebrand Frank , Migliorini Filippo
Published: August 2022

Background

The efficacy of various common treatment options for dry eye disease (DED) has been investigated against placebo. However, the potential beneficial effect of placebo in the management of DED is still unclear.

Aim

This meta-analysis investigated the impact of placebo administration in DED in Ocular Surface Disease Index (OSDI), Schirmer I test (SIT), tear breakup time (TBUT), corneal staining, and complications.

Method

This meta-analysis and systematic review was conducted according to the 2020 PRISMA guidelines. In March 2022, Pubmed, Web of Science, Google Scholar, and Embase were accessed. All the randomised clinical trials which investigated any active treatment against a placebo control group were considered. The following data were extracted at baseline and at last follow-up: Ocular Surface Disease Index (OSDI), tear breakup time test (TBUT), Schirmer I test (SIT), corneal staining.

Results

Data from 56 studies (12,205 patients) were retrieved. Placebo administration is not effective in improving TBUT (P = 0.3), OSDI (P = 0.2), SIT (P = 0.1) and corneal staining (P = 0.1) from baseline to last follow-up. Active treatment led to a higher TBUT and SIT compared to placebo administration (P < 0.0001). The active treatment resulted in a lower OSDI compared to placebo administration (P = 0.0005). Five studies reported data on the corneal staining. No difference was found between placebo administration and active treatment (P = 0.8).

Conclusion

Placebo administration does not impact symptoms of DED and can be successfully employed to evaluate the efficacy of active treatments.
Early childhood education in Africa: Between overambitious global objectives, the need to reflect local interests, and educational choices
Authors: Akkari Abdeljalil
Published: August 2022

The African continent represents the part of the world where early childhood care and education (ECCE) preceding primary schooling is the least developed. It is therefore essential to propose an analysis of the prospects for the development of early childhood education in the coming years. This article deals in the first instance with the international infatuation for pre-primary education based on both scientific evidence and also international agendas. It then explores the possibilities of putting forward a coherent African response to global demands concerning early childhood education and promoting the inclusion of local cultural content in designing pre-primary educational structures. Finally, the article suggests some principles that might guide international cooperation activities affecting the early childhood sector.
Estimating the effects of physical violence and serious injury on health-related quality of life: Evidence from 19 waves of the Household, Income and Labour Dynamics in Australia Survey
Authors: Keramat Syed Afroz , Nguyen Kim-Huong , Perales Francisco , Seidu Abdul-Aziz , Mohammed Aliu , Ahinkorah Bright Opoku , Comans Tracy
Published: August 2022

Objective

This study aims to investigate the effect of physical violence and serious injury on health-related quality of life in the Australian adult population.

Methods

This study utilised panel data from the Household, Income and Labour Dynamics in Australia (HILDA) Survey. HRQoL was measured through the physical component summary (PCS), mental component summary (MCS), and short-form six-dimension utility index (SF-6D) of the 36-item Short-Form Health Survey (SF-36). Longitudinal fixed-effect regression models were fitted using 19 waves of the HILDA Survey spanning from 2002 to 2020.

Results

This study found a negative effect of physical violence and serious injury on health-related quality of life. More specifically, Australian adults exposed to physical violence and serious injury exhibited lower levels of health-related quality of life. Who experienced physical violence only had lower MCS (β = −2.786, 95% CI: −3.091, −2.481) and SF-6D (β = −0.0214, 95% CI: −0.0248, −0.0181) scores if switches from not experiencing physical violence and serious injury. Exposed to serious injury had lower PCS (β = −5.103, 95% CI: −5.203, −5.004), MCS (β = −2.363, 95% CI: −2.480, −2.247), and SF-6D (β = −0.0585, 95% CI: −0.0598, −0.0572) score if the adults not experiencing physical violence and serious injury. Further, individuals exposed to both violence and injury had substantially lower PCS (β = -3.60, 95% CI: -4.086, -3.114), MCS (β = −6.027, 95% CI: −6.596, −5.459), and SF-6D (β = −0.0716, 95% CI: −0.0779, −0.0652) scores relative to when the individuals exposed to none.

Conclusion

Our findings indicate that interventions to improve Australian adults’ quality of life should pay particular attention to those who have experienced physical violence and serious injury. Our findings suggest unmet mental health needs for victims of physical violence and serious injuries, which calls for proactive policy interventions that provide psychological and emotional therapy.
The Size and Spatial Extent of Neighborhood Price Impacts of Infill Development: Scale Matters?
Authors: Nygaard Christian A. , Galster George , Glackin Stephen
Published: August 2022

Infill investments are argued to mitigate environmental footprints, regenerate places and accommodating population growth, but frequently generate local opposition. However, there is a dearth of knowledge around how different types of infill affect different segments of local property markets, how persistent effects are and how far they reach. Using detailed geocoded infill development activity and sales data, we test the price level and trajectory impacts of five infill types, distinguished by the net scale of additional dwellings, on property prices within five concentric 100-meter rings. Using an adjusted interrupted time-series estimation strategy with locality, property and neighborhood characteristic controls we find that developments that generate a net increase in dwellings of four or less, typically result in an appreciation in the average sales prices of proximate dwellings. Moderate and large-scale developments generate negative price effects, but these effects predominantly affect apartments and townhouses, not the dominant detached house submarket. Over time, amenity effects and local market potential may even have a further positive expectation effect on detached house prices. Infill type differentiation shows that urban densification may result in positive affordability outcome in the apartment submarket, but has the opposite effects in the detached house submarket. Divergent price trajectories also contribute to widening wealth disparities.
Knowledge of art versus artistic knowledge. I. The GAKhN “Encyclopedia of Artistic Terminology” in the context of European intellectual history
Authors: Plotnikov Nikolaj
Published: August 2022

In this first of two articles, I look at the project for the “Encyclopedia of Artistic Terminology” in connection with the idea of a synthesis of the “artistic sciences” as the principal task of the State Academy of Artistic Sciences (GAKhN, 1921–1930) in Moscow. The most important feature of the Academy was the unity of its epistemological conception (the system of artistic sciences) and the institutional structure of the Academy (its “departments,” “sections,” and “laboratories”), which embodied the interdisciplinary intention of uniting the philosophy of art, the artistic sciences, and artistic experimentation. I analyze the connection of the project with the task of “concept formation” in the artistic sciences, which was recognized in European philosophy at the beginning of the twentieth century as the main criterion for scientificity in the human sciences. I also investigate how the Encyclopedia project, developed by Gustav Shpet, took into account previous attempts to systematize aesthetic terminology (in nineteenth-century dictionaries). I show that the project of the “Encyclopedia of Artistic Terminology” was not the sole attempt to create a new dictionary of aesthetic concepts and of the cultural sciences. Similar projects were being developed in the 1920s and 30s in Germany (Erich Rothacker planned to produce Handwörterbuch der gesamten gemeingeisteswissenschaftlichen und kulturphilosophischen Grundbegriffe) and in France (Étienne Souriau published Vocabulaire d’esthétique; see Souriau 2010).
Biochemical and clinical studies of putative allergens to assess what distinguishes them from other non-allergenic proteins in the same family
Authors: Glenn Kevin C. , Silvanovich Andre , Lee Soon Goo , Allen Aron , Park Stephanie , Dunn S. Eliza , Kessenich Colton , Meng Chen , Vicini John L. , Jez Joseph M.
Published: August 2022

Many protein families have numerous members listed in databases as allergens; however, some allergen database entries, herein called “orphan allergens”, are members of large families of which all other members are not allergens. These orphan allergens provide an opportunity to assess whether specific structural features render a protein allergenic. Three orphan allergens [Cladosporium herbarum aldehyde dehydrogenase (ChALDH), Alternaria alternata ALDH (AaALDH), and C. herbarum mannitol dehydrogenase (ChMDH)] were recombinantly produced and purified for structure characterization and for clinical skin prick testing (SPT) in mold allergic participants. Examination of the X-ray crystal structures of ChALDH and ChMDH and a homology structure model of AaALDH did not identify any discernable epitopes that distinguish these putative orphan allergens from their non-allergenic protein relatives. SPT results were aligned with ChMDH being an allergen, 53% of the participants were SPT (+). AaALDH did not elicit SPT reactivity above control proteins not in allergen databases (i.e., Psedomonas syringae indole-3-acetaldehyde dehydrogenase and Zea mays ALDH). Although published results showed consequential human IgE reactivity with ChALDH, no SPT reactivity was observed in this study. With only one of these three orphan allergens, ChMDH, eliciting SPT(+) reactions consistent with the protein being included in allergen databases, this underscores the complicated nature of how bioinformatics is used to assess the potential allergenicity of food proteins that could be newly added to human diets and, when needed, the subsequent clinical testing of that bioinformatic assessment.

Trial registration number and date of registration AAC-2017-0467, approved as WIRB protocol #20172536 on 07DEC2017 by WIRB-Copernicus (OHRP/FDA Registration #: IRB00000533, organization #: IORG0000432).
Different Types, Different Reactions? How Civil Society Organizations Respond to Right-Wing Extremism
Authors: Lundberg Erik
Published: August 2022

Extreme right-wing violence has resulted in an intense academic debate on how democratic actors can respond to movement on the extreme right. This article explores how various types of CSOs perceive their role, interest, and willingness when it comes to counteracting right-wing extremism. Building on a theoretical framework that makes visible a variety of CSO responses and differences between types of CSOs, the results show that CSOs view themselves as having a watchdog role in relation to right-wing extremism. However, CSOs place the principal responsibility of response to right-wing extremism outside organized civil society in the hands of politicians, citizens, and the media. In addition, not all CSOs are willing to respond in the same way or to the same extent. Humanitarian and social service organizations are more inclined to engage in dialogue and protest compared with sports and recreation organizations and culture organizations. The article concludes by discussing the notion that bridging organizations may be more willing to respond to right-wing extremism and to use dialogue and deliberation compared to bonding organizations.
Arabica-coffee and teobroma-cocoa agro-industrial waste biosorbents, for Pb(II) removal in aqueous solutions
Authors: Lavado-Meza Carmencita , De la Cruz-Cerrón Leonel , Cisneros-Santos Gregorio , De la Cruz Alex H. , Angeles-Suazo Julio , Dávalos-Prado Juan Z.
Published: August 2022

Agro-industrial waste biosorbents of arabica–coffee (WCA) and theobroma–cocoa (WCT) have been characterized and tested to remove Pb(II) from aqueous media. The maximum adsorption capacity of WCA and WCT (qmax = 158.7 and 123.5 mg·g−1, respectively) is comparable or even higher than for several other similar agro-industrial waste biosorbents reported in the literature. Structural and morphological characterization were performed by infrared spectrometry with Fourier transform (FT-IR), scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDS), and charge measurements at the zero point charge (pHPZC). Both biosorbents, WCA and WCT, show cracked surfaces with heterogeneous plates which ones include functional adsorption groups such as OH, C = O and C-O-C. Optimal Pb(II) adsorption occurs for a pH between 4 and 5 at [WCA] and [WCT] dose concentrations of 2 g·L−1. We found that the adsorption process follows pseudo-second order kinetics with a rapid growth rate (almost six times larger for WCA than for WCT), basically controlled by the chemisorption process. The regeneration of both biosorbents was carried out in an eluent of 0.1M HNO3 and they can be efficiently reused up to 5 times.
Detection and assessment of dust mite allergens in an indoor environment in Anhui, China
Authors: Xue Qiqi , Zou Minghui , Guo Junjie , Teng Qiao , Zhang Qiqi , Sheng Lingwei , Xu Sijia , Fang Can , Yao Ning , Li Yuanyuan , Zhao Jinhong
Published: August 2022

Dust in the home environment is thought to be a potential trigger for increasing allergic diseases, such as allergic rash, rhinitis, asthma, and other conditions, associated with dust mites. To verify the status of dust mite prevalence in indoor surroundings, we collected 189 dust samples from the air conditioner filters (n = 75) and floors (n = 114) of households, schools, and hotels in the Anhui area, China. All samples were measured for dust mite breeding rate and breeding density under light microscopy and analyzed for dust mite species Dermatophagoides farinae 1 (Der f 1) and Dermatophagoides pteronyssinus 1 (Der p 1) allergen using enzyme-linked immunosorbent assay (ELISA). The dust mite breeding rates were 34.67% (26/75) and 20.18% (23/114), respectively, in the dust samples from the floor and air conditioning filters. The breeding density was the highest in households (10/g), followed by schools (9/g) and hotels (4/g). ELISA indicated that the allergen threshold (2.0 µg/g dust) of Der f 1 was exceeded in only two samples and Der p 1 in one sample. Additionally, a questionnaire was used to investigate the health knowledge on allergic diseases involved in indoor facilities, finding that most allergy sufferers were aware that indoor dust might be responsible for their conditions. The findings suggest that regular maintenance of indoor hygiene and cleaning of air-conditioning filters should reduce the risks of exposure to indoor allergens.
Gemeinwesenarbeit in Erzählcafés für geflüchtete Frauen
Authors: Romppel Joachim , Hassan Rebecca
Published: August 2022

Die Sozialarbeiterin Yildiz Sahinde Demirer hat mit anderen Frauen das Projekt „Erzählcafés für geflüchtete Frauen“ in Trägerschaft der Landeshauptstadt Hannover (2018 bis 2021) konzipiert und umgesetzt. In fünf Stadtteilen konnten sich die Frauen regelmäßig treffen und austauschen, sich beteiligen und kamen zu Wort. Ihre Arbeit bezeichnet Demirer als Gemeinwesenarbeit mit politischen und feministischen Schwerpunkten. Die wissenschaftliche Begleitung durch Rebecca Hassan und Joachim Romppel von der Hochschule Hannover führte zur Dokumentation und Auswertung des Modellprojekts. Das Bundesamt für Migration und Flüchtlinge (BAMF) förderte das Projekt. Bemerkenswert sind die Erfolge dieser nonformalen Bildungsarbeit.
Volumetric Imaging of Neural Activity by Light Field Microscopy
Authors: Bai Lu , Zhang Zhenkun , Ye Lichen , Cong Lin , Zhao Yuchen , Zhang Tianlei , Shi Ziqi , Wang Kai
Published: August 2022

Recording the highly diverse and dynamic activities in large populations of neurons in behaving animals is crucial for a better understanding of how the brain works. To meet this challenge, extensive efforts have been devoted to developing functional fluorescent indicators and optical imaging techniques to optically monitor neural activity. Indeed, optical imaging potentially has extremely high throughput due to its non-invasive access to large brain regions and capability to sample neurons at high density, but the readout speed, such as the scanning speed in two-photon scanning microscopy, is often limited by various practical considerations. Among different imaging methods, light field microscopy features a highly parallelized 3D fluorescence imaging scheme and therefore promises a novel and faster strategy for functional imaging of neural activity. Here, we briefly review the working principles of various types of light field microscopes and their recent developments and applications in neuroscience studies. We also discuss strategies and considerations of optimizing light field microscopy for different experimental purposes, with illustrative examples in imaging zebrafish and mouse brains.
Registered Nurses’ Perspectives of the Impact of a Post-registration Education Qualification on Patient Care and Clinical Practice in Cancer Care: a Qualitative Study
Authors: Kerr Helen , McSorley Oonagh , Donovan Monica
Published: August 2022

Student evaluation of teaching is routinely completed as modules and programmes of study at higher education institutions conclude. The evaluations are often focused on the educational value and experience. For programmes with healthcare professionals as students, the impact of the learning on patient care and clinical practice is not routinely captured in these student evaluations. These insights are crucial as the definitive impact of learning for many educational programmes of study for healthcare professionals is to enhance patient outcomes. The aim of this qualitative research study was to capture the impact of a post-registration Specialist Practice in cancer pathway for registered nurses in the context of Northern Ireland following completion of the programme. Eleven participants engaged in interviews in 2021 who had completed the education programme from 2013 to 2021. Two themes inductively emerged from the data which provided insights into the specific impact of the education programme on patient care and clinical practice. Theme one identified patient outcomes improved, and was related to five sub themes; development of nurse’s clinical knowledge; enhanced awareness of the holistic impact of cancer; greater understanding of patient services available; development of clinical networks; and greater decision-making ability. Theme two related to the impact of the qualification on clinical practice through an increase in their professional credibility within the multidisciplinary team in cancer services. The debate on how to capture the impact of education on patient care and clinical practice in cancer care, should consider how to routinely capture this data.
Production of efficient carbon fiber from different solid waste residuals for adsorption of hazardous metals from wastewater samples
Authors: Abou-Hadid Ayman F. , El-Behairy Usama A. , Elmalih Mahmoud M. , Amdeha Enas , El Naggar Ahmed M. A. , Taha Mohamed H. , Hussein Ahmed E. M.
Published: August 2022

Uranium (as a hazardous and radioactive element) removal from wastewater requires reliable technology and proper functional materials. Carbon fiber species that are produced from agricultural solid waste can be a proper type of low-cost adsorbents for wide uses in wastewater treatment. In this work, two carbon fiber species labeled CF-RH and CF-SCB were synthesized from two different agricultural wastes, namely, rice husk and sugarcane bagasse respectively. The structural properties of carbon fiber were verified by XRD, FTIR, and Raman, spectroscopy. Both nitrogen-adsorption–desorption BET surface area and TEM were performed to figure out the textural characteristics of the presented sorbents. The charges on surfaces of the fibers were detected via zeta potential analysis. The prepared carbon fibers were applied for uranium removal from aqueous solution by adsorption technique. The acquired data display that the equilibrium time was 240 min. The results of adsorption process are nicely fitted with pseudo-second-order-kinetic and Langmuir isotherm models. The maximum sorption capacity was 21.0 and 29.0 mg/g for CF-RH and CF-SCB, respectively. Sorption thermodynamics declare that adsorption of U(VI) is an endothermic, spontaneous, and feasible process. The picked findings of this study could emphasize high reliability of the introduced adsorbents in efficient tackling of water contaminants.
An improved immersed boundary method by coupling of the multi-direct forcing and Fourier pseudo-spectral methods
Authors: Mariano Felipe Pamplona , Moreira Leonardo de Queiroz , Nascimento Andreia Aoyagui , Silveira-Neto Aristeu
Published: August 2022

The present paper aims to report an improve on the development of the IMERSPEC methodology, which is a methodology that couples the Fourier pseudo-spectral and immersed boundary methods, which can now solve flows over complex geometries. In the present work, the Lagrangian mesh that represents the immersed body inside the flow does not have to coincide with the Eulerian mesh. Furthermore, a high accuracy for the resultant methodology is achieved. These two important improvements arise from the development of the multi-direct forcing method and used to calculate the force field of the immersed boundary method. In order to verify the IMERSPEC methodology, a manufactured solution technique was used. The results of a refined mesh were employed, and different distribution and interpolation functions were used and analysed. Finally, flows over a backward-facing step geometry were simulated in two dimensions. This type of flow presents several physical features, for example, detachment and reattachment of the boundary layer and vortex generation, which are difficult to capture using numerical solutions. A comparison with the experimental data is presented and shows that the IMERSPEC methodology is promising for computational fluid dynamics applications and its analysis.
Biomarkers and the quadriceps femoris muscle architecture assessed by ultrasound in older adults with heart failure with preserved ejection fraction: a cross-sectional study
Authors: Fuentes-Abolafio Iván José , Ricci Michele , Bernal-López María Rosa , Gómez-Huelgas Ricardo , Cuesta-Vargas Antonio Ignacio , Pérez-Belmonte Luis Miguel
Published: August 2022

Background

Sarcopenia is an important comorbidity in patients with heart failure with preserved ejection fraction (HFpEF). The ultrasound (US) assessment has all the advantages of being used in primary care to assess muscle quantity and quality. Some biomarkers could be indicative of muscle mass loss.

Aims

To describe the quantitative and qualitative characteristics of the quadriceps femoris assessed by US in older adults with HFpEF and to assess the relationship of the blood and urinary biomarkers, the polypharmacy and comorbidities with US outcomes in older adults with HFpEF.

Methods

A cross-sectional study was conducted. 76 older adults with HFpEF were included. The quadriceps femoris muscle thickness (MT, cm), the subcutaneous fat tissue thickness (FT, cm), the muscle echo intensity (MEI) and the subcutaneous fat tissue echo intensity (FEI) were assessed by US in a non-contraction (non-con) and contraction (con) situations. Polypharmacy, comorbidities, blood and urine biomarkers were also collected.

Results

The carbohydrate antigen 125 (CA-125), the folic acid and the urine creatinine shared the 86.6% variance in the non-con MT, adjusted by age, sex and body mass index (BMI). The folic acid shared the 38.5% of the variance in the con MT, adjusted by age, sex and BMI. The glycosylated haemoglobin explained the 39.6% variance in the non-con MEI, adjusted by age, sex and BMI. The chlorine (Cl−) explained the 40.2% of the variance in the non-con FT, adjusted by age, sex and BMI. The polypharmacy and the folic acid explained the 37.9% of variance in the non-con FEI, while the polypharmacy and the thyrotropin (TSH) shared the 44.4% of variance in the con FEI, both adjusted by age, sex and BMI. No comorbidities, polypharmacy, or blood and urinary biomarkers could explain the con MEI and the con FT variance.

Conclusions

Blood and urinary biomarkers obtained in routine analyses could help clinicians detect US outcome changes in older adults with HFpEF and identify a worsening of sarcopenia.

Trial registration

NCT03909919. April 10, 2019. Retrospectively registered.
Thermodynamics fundamentals and energy efficiency for the separation and high-valued utilization of Fischer–Tropsch heavy oil
Authors: Liu Zongchao , Li Hong , Liu Suli , Chen Jiuzhou , Zhang Zisheng , Li Xingang , Zhang Angui , Yuan Wei , Gao Xin
Published: August 2022

The development trend of Fischer–Tropsch (F–T) technology is to develop high value-added products. The separation of linear α-olefins with low cost is an effective method. Nevertheless, the lack of thermodynamic data and the huge energy consumption are the two main problems restricting the development of the separation process. The thermodynamic data of the key components (1-dodecene and n-dodecane) in the F–T product were measured. The Wilson binary interaction parameters of the key components were obtained. Next, one traditional distillation column sequence and two dividing wall column (DWC) sequences were designed to separate the F–T heavy oil to obtain narrow fractions with different carbon numbers. Then, the obtained fractions of C10 and C12 were simulated to obtain 1-decene and 1-dodecene, respectively. There was a traditional distillation and a differential pressure thermal coupling distillation process. When separating 95.0% purity 1-decene and 1-octene, the direct DWC process and differential pressure thermal coupled distillation are an excellent combination, which can reduce the energy by 33.1% (i.e., 11,286 kW) and total annual cost by 15.9% (i.e., 3.96 × 106 $) compared with traditional distillation.
Cryptocurrencies and stablecoins: a high-frequency analysis
Authors: Barucci Emilio , Moncayo Giancarlo Giuffra , Marazzina Daniele
Published: August 2022

We analyze cryptoasset markets (cryptocurrencies and stablecoins) at high frequency. We investigate intraday patterns. We show that Tether plays a crucial role as a safe haven and/or store of value facilitating trading in cryptocurrencies without going through traditional currencies. Markets centered on cryptocurrencies and stablecoins play a primary role aggregating preference/technology shocks and heterogeneous opinions, instead markets centered on the US dollar play a marginal role on price formation.
An improvement of manufacturing process using 3D printing technology for overhead line components on railway electrification
Authors: Lee Kiwon , Jung Hosung
Published: August 2022

In an electric railway, an overhead contact system (OCS) is assembled with many components, and it maintains a voltage of 25 kV to supply electricity to the electric trains. As electric trains grow faster, the overhead line comes to employ a diverse range of materials to deliver electricity and maintain high tension. Overhead lines supply electricity to electric trains through mechanical contact with a pantograph, and since they are not fault-tolerant, they require high reliability. That makes it take a long time to develop and supply components and also makes it difficult and time consuming to apply new materials or new designs to components. This study proposes a manufacturing process for overhead line components using 3D printing technology. For this, a clevis terminal clamp for high-speed railway was chosen and a design drawing was created with 3D scanning. For molding, additive manufacturing technology was used. The study castings were obtained by applying precision casting and sand mold casting methods, respectively, and their elongation and tensile strength were compared with products made with a traditional method.
Pressure-Induced Fibroid Ischemia: First-In-Human Experience with a Novel Device for Laparoscopic Treatment of Symptomatic Uterine Fibroids
Authors: Tal Michael G. , Keidar Ran , Magnazi Gilad , Henn Ohad , Kim Jin Hee , Chudnoff Scott G. , Stepp Kevin J.
Published: August 2022

The purpose of this study was to assess the feasibility of use of a novel uterine fibroid treatment device hypothesized to cause fibroid infarction by increasing intra-tumoral pressure. Between August 2019 and January 2020, 21 uterine fibroids were treated in 16 symptomatic pre-menopausal black women. Pelvic magnetic resonance imaging was performed before the procedure, a day after the procedure and at 1, 3, 6, and 12 months. The subjects were also followed for clinical outcomes and quality of life up to 12 months at a single investigational site. At 3 months, the mean reduction in the fibroid volume was 36.3% (P = .002). Incremental reduction in volume peaked at the end of the follow-up, at the 12-month mark (60.4%; P = .008). There were no procedures in which the users failed to perform laparoscopic pressure suturing of fibroids with the pressure-induced fibroid ischemia device. Improvement in the quality of life was evident in the Health-Related Quality of Life total, Energy/Mood, Control, and Sexual Function domains of the Uterine Fibroid Symptom and Quality of Life questionnaire at 3 months post-procedure. Unanticipated risks were not identified. Serious adverse events were not identified. The initial clinical assessment of the pressure-induced fibroid ischemia device supports feasibility of the approach and does not reveal serious safety concerns. Trial is currently being registered retrospectively (This was a feasibility study and therefore registration was not mandatory).
Does Bother/Distress Contribute to the Diagnosis of Premature Ejaculation?
Authors: Rowland David L. , McNabney Sean M. , Hevesi Krisztina
Published: August 2022

Introduction

The role of bother/distress in the diagnosis of premature ejaculation (PE) has received minimal investigation compared with the 2 other diagnostic criteria, ejaculatory control and ejaculatory latency (EL).

Aim

This study assessed (i) the added variance explained by bother/distress to the diagnostic accuracy of PE and (ii) determined its overall contribution to a PE diagnosis.

Methods

The 3 diagnostic criteria for PE were assessed in 2,589 men (mean age = 38.2 years, SD = 13.5) in order to determine the contribution of each factor to a dysfunctional diagnosis. A series of regression and discriminant analyses were used to assess the value of bother/distress in explaining ejaculatory control and in predicting accuracy of PE group status. Commonality analysis was used to determine the relative contribution of each of these factors to the diagnosis of PE.

Main Outcome Measure

The major outcome was the quantified contribution of “bother/distress” to a PE diagnosis.

Results

Bother/distress accounted for about 3–4% of the variation in ejaculatory control and added only minimally to the prediction accuracy of PE group status (no, probable, definite PE). Commonality analysis indicated that bother/distress comprised about 3.6% of the unique explained variation in the PE diagnosis, compared with ejaculatory control and EL which contributed 54.5% and 26.7%, respectively. Common variance among factors contributed the remaining 15.5% to the PE diagnosis.

Clinical Translation

Bother/distress contributes least to the determination of a PE diagnosis. Its contribution is largely redundant with the unique and combined contributions of ejaculatory control and EL.

Strengths and Limitations

Using a well-powered and multivariate analysis, this study parsed out the relative contributions of the 3 diagnostic criteria to a PE diagnosis. The study is limited by its use of estimated EL, a single item assessment of bother/distress, and the lack of differentiation of PE subtypes, lifelong and acquired.

Conclusion

Bother/distress contributes minimally to the PE diagnosis, yet its assessment may be key to understanding the experiences of the patient/couple and to developing an effective treatment strategy.
Selecting EHR-driven recruitment strategies: An evidence-based decision guide
Authors: Grout Randall W. , Hood Dan , Nelson Sarah J. , Harris Paul A. , Embí Peter J.
Published: August 2022

Participant recruitment for research is a persistent bottleneck that can be improved by leveraging electronic health records (EHRs). Despite emerging evidence for various EHR-driven approaches, guidance for those attempting to select and use such approaches is limited. The national Recruitment Innovation Center established the EHR Recruitment Consult Resource (ERCR) service line to support multisite studies through implementation of EHR-driven recruitment strategies. As the ERCR, we evolved a guide through 17 consultations over 3 years with multisite studies recruiting in diverse biomedical research domains. We assessed literature and engaged domain experts to identify five key EHR-driven recruitment strategies: direct to patient messages, candidate lists for mailings/calls, direct to research alerts, point of care alerts, and participant registries. Differentiating factors were grouped into factors of study population, study protocol and recruitment workflows, and recruitment site capabilities. The decision matrix indicates acceptable or preferred strategies based on the differentiating factors. Across the ERCR consultations, candidate lists for mailing or calls were most common, participant registries were least frequently recommended, and for some studies no EHR-driven recruitment was recommended. Comparative effectiveness research is needed to refine further evidence for these and potentially new strategies to come.
Natural language processing in-and-for design research
Authors: Siddharth L. , Blessing Lucienne , Luo Jianxi
Published: August 2022

We review the scholarly contributions that utilise natural language processing (NLP) techniques to support the design process. Using a heuristic approach, we gathered 223 articles that are published in 32 journals within the period 1991–present. We present state-of-the-art NLP in-and-for design research by reviewing these articles according to the type of natural language text sources: internal reports, design concepts, discourse transcripts, technical publications, consumer opinions and others. Upon summarising and identifying the gaps in these contributions, we utilise an existing design innovation framework to identify the applications that are currently being supported by NLP. We then propose a few methodological and theoretical directions for future NLP in-and-for design research.
Surface layer response to heterogeneous tree canopy distributions: roughness regime regulates secondary flow polarity
Authors: Joshi P. , Anderson W.
Published: August 2022

Large-eddy simulation was used to model turbulent atmospheric surface layer (ASL) flow over canopies composed of streamwise-aligned rows of synthetic trees of height,

$h$

, and systematically arranged to quantify the response to variable streamwise spacing,

$\delta _1$

, and spanwise spacing,

$\delta _2$

, between adjacent trees. The response to spanwise and streamwise heterogeneity has, indeed, been the topic of a sustained research effort: the former resulting in formation of Reynolds-averaged counter-rotating secondary cells, the latter associated with the

$k$

- and

$d$

-type response. No study has addressed the confluence of both, and results herein show secondary flow polarity reversal across ‘critical’ values of

$\delta _1$

and

$\delta _2$

. For

$\delta _2/\delta \lesssim 1$

and

$\gtrsim 2$

, where

$\delta$

is the flow depth, the counter-rotating secondary cells are aligned such that upwelling and downwelling, respectively, occurs above the elements. The streamwise spacing

$\delta _1$

regulates this transition, with secondary cell reversal occurring first for the largest

$k$

-type cases, as elevated turbulence production within the canopy necessitates entrainment of fluid from aloft. The results are interpreted through the lens of a benchmark prognostic closure for effective aerodynamic roughness,

$z_{0,{Eff.}} = \alpha \sigma _h$

, where

$\alpha$

is a proportionality constant and

$\sigma _h$

is height root mean square. We report

$\alpha \approx 10^{-1}$

, the value reported over many decades for a broad range of rough surfaces, for

$k$

-type cases at small

$\delta _2$

, whereas the transition to

$d$

-type arrangements necessitates larger

$\delta _2$

. Though preliminary, results highlight the non-trivial response to variation of streamwise and spanwise spacing.
Anisotropic swimming and reorientation of an undulatory microswimmer in liquid-crystalline polymers
Authors: Lin Zhaowu , Yu Zhaosheng , Li Jinxing , Gao Tong
Published: August 2022

Microorganisms can efficiently navigate in anisotropic complex fluids, but the precise swimming mechanisms remain largely unexplored. Their dynamics is determined by the interplay between multiple effects, including the fluid's orientation order, swimmer's undulatory gait and the finite length. Here, we extend the numerical study of the two-dimensional undulatory motions of a flexible swimmer in lyotropic liquid-crystalline polymers (LCPs) by Lin et al. (J. Fluid Mech., vol. 921, 2021, p. A25) to the scenario of arbitrary swimming directions with respect to the nematic director. The swimmer is modelled as a nearly inextensible yet flexible fibre with imposed travelling-wave-like actuation. We investigate the orientation-dependent swimming behaviours in nematic LCPs for an infinitely long sheet (i.e. Taylor's swimming sheet model) and finite-length swimmers. We demonstrate that the swimmer must be sufficiently stiff to produce undulatory deformations to gain net motions. Moreover, a motile finite-length swimmer can reorient itself to swim parallel with the nematic director, due to a net body torque arising from the asymmetric distribution of the polymer force along the body.
Using ground-based thermal imagery to estimate debris thickness over glacial ice: fieldwork considerations to improve the effectiveness
Authors: Aubry-Wake Caroline , Lamontagne-Hallé Pierrick , Baraër Michel , McKenzie Jeffrey M. , Pomeroy John W.
Published: August 2022

Debris-covered glaciers are an important component of the mountain cryosphere and influence the hydrological contribution of glacierized basins to downstream rivers. This study examines the potential to make estimates of debris thickness, a critical variable to calculate the sub-debris melt, using ground-based thermal infrared radiometry (TIR) images. Over four days in August 2019, a ground-based, time-lapse TIR digital imaging radiometer recorded sequential thermal imagery of a debris-covered region of Peyto Glacier, Canadian Rockies, in conjunction with 44 manual excavations of debris thickness ranging from 10 to 110 cm, and concurrent meteorological observations. Inferring the correlation between measured debris thickness and TIR surface temperature as a base, the effectiveness of linear and exponential regression models for debris thickness estimation from surface temperature was explored. Optimal model performance (R2 of 0.7, RMSE of 10.3 cm) was obtained with a linear model applied to measurements taken on clear nights just before sunrise, but strong model performances were also obtained under complete cloud cover during daytime or nighttime with an exponential model. This work presents insights into the use of surface temperature and TIR observations to estimate debris thickness and gain knowledge of the state of debris-covered glacial ice and its potential hydrological contribution.
Participation and Objectivity
Authors: Koskinen Inkeri
Published: August 2022

Many philosophers of science have recently argued that extra-academic participation in scientific knowledge production does not threaten scientific objectivity. Quite the contrary: Citizen science, participatory projects, transdisciplinary research, and other similar endeavours can even increase the objectivity of the research conducted. Simultaneously, researchers working in fields in which such participation is common have expressed worries about various ways in which it can result in biases. In this article I clarify how these arguments and worries can be compared, and how extra-academic participation can both increase and threaten the objectivity of the research conducted.