bluuebunny/crossref_metadata_2025 huggingface dataset:
Immune function analysis of LsSd, a transcription factor of the Hippo signaling pathway, in the cigarette beetle Lasioderma serricorne
Authors: Zhang Yue , Yang Jiapeng , Dai Renhuai , Yang Wenjia , Zhang Xiaomin
Published: October 2022

The Scalloped (Sd) is a transcription factor that regulates organ size control in the Hippo-signaling pathway. Recent studies have showed that Hippo signaling also functions in the innate immune response. Although the Sd gene has been reported in many insects, their immune functions remain unexplored. In this study, the LsSd gene of Lasioderma serricorne, with a complete open reading frame that encodes a protein composed of 402 amino acids was identified. LsSd was predominantly expressed in early pupae. Tissue-specific analyses revealed that the highest concentrations of LsSd were detected in the midgut and brain. At 1–24 h after Escherichia coli infection, LsSd expression increased substantially. However, LsSd expression was downregulated 3–12 h after Staphylococcus aureus infection. RNA interference-mediated silencing of the LsSd transcript resulted in deformed, considerably smaller, and degenerated wings. Meanwhile, LsCycE, LsDiap1, and LsVg, which are involved in cell proliferation and wing development, were drastically reduced when LsSd was depleted. In a survival assay, the LsSd knockdown considerably decreased the susceptibility to S. aureus, a gram-positive bacterium. In addition, knockdown of LsSd remarkably downregulated the transcription of LsCact in response to S. aureus stimulation, while upregulating the expression of five immune-related genes. Our results provide conclusive proof for the important roles of LsSd in the immune response of L. serricorne.
Initial validation of the Chinese version VIA Youth-96 and age-related changes in character strengths among adolescents
Authors: Cheng Xiaotong , Xu Shuang , Huang Yuyan , Qin Cheng , Liu Kezhi , Tian Mingyuan , Liao Xiaoyuan , Zhou Xinyi , Xiang Bo , Chen Jing , Lei Wei
Published: October 2022

This study aimed to preliminary examine the psychometric properties of the Chinese version 96-item VIA Inventory for Youth (VIA Youth-96) by analyzing the internal consistency, factorial validity, and criterion validity, and to examine the age-related changes in character strengths (CSs) among adolescents. The sample consisted of 959 adolescents aged 10–17 (49.5% boys). Participants completed the Chinese version VIA Youth-96, along with the Perceived Parental Autonomy Support Scale, and questionnaires assessing life satisfaction and self-efficacy online. The Chinese version VIA Youth-96 showed a good fit for the original four-factor structure, and CS scores were significantly correlated with life satisfaction and self-efficacy indicating a good criterion validity of the scale. The internal consistency was 0.54–0.86 for subscales. Moreover, this study revealed significant age-related changes in CSs among adolescents, eight CSs significantly linearly declined by age. These results suggested that the Chinese version VIA Youth-96 is a valid tool for assessing CSs in adolescents and that CSs are declined linearly by age during adolescence.
The differences in learning motivation of college freshmen in Northwest China
Authors: Qiao Ke , Xu Ruizhao , Liu Bailong , Chen Xiangyang , Gu Pan
Published: October 2022

The study aimed to investigate the learning motivation of freshmen from a university in Northwest China, which can supply a reference for improving their learning quality and objectives. Data were collected from 800 freshmen of different majors with a learning motivation questionnaire. Differences in learning motivation between different majors, genders, regions, and students are studied. The results show that gender, seeking knowledge orientation, and material pursuit have significant effects on students’ learning motivation. The gender had a significant impact on personal achievement and the only child or not had an obvious effect on material pursuit, while other factors had no obvious difference in gender, regional, and only child or not, while other factors on the gender, regional, and whether the one-child had no obvious difference. According to the results of the research, measures to improve learning motivation are proposed. Our research results provide a reference for improving learning attitude and the quality of universities.
Effectiveness of international virtual training on biorisk management in the context of COVID-19
Authors: Qasmi Shamsul Arfin , Standley Claire , Mohsin Saima , Sarwar Samreen , Malik Laila , Aziz Fatima
Published: October 2022

Introduction

The COVID-19 pandemic has resulted in enormous increases in laboratory activities to keep pace with diagnostic testing and research efforts. However, traditional training, technical assistance, and capacity-building approaches were disrupted by the travel and movement restrictions put in place to control the spread of the disease. To address the needs of laboratorians and managers to conduct laboratory activities safely and securely during the pandemic, a highly interactive virtual training (IVT) workshop on biorisk management during COVID-19 was conducted through active learning strategies that connected speakers with participants. The objective of the training was to increase the basic knowledge and standards of biosafety and biosecurity practices, risk assessment, and control measures with reference specifically to the context of the COVID-19 pandemic and apply a rigorous evaluation methodology to assess the effectiveness of the IVT. The training covered a broad range of topics and encompassed national to international guidelines.

Methods

Participants were selected through official channels at the national level, focusing on institutions within Pakistan. The sessions included lectures from international experts in biorisk management concepts, and incorporated poll questions as well as pre- and post-tests and feedback on the speakers' knowledge and presentation skills, to increase interactivity. The pre- and post-test comprised similar multiple-choice questions and provided to every participant to ascertain the impact of the training on awareness and knowledge of biorisk management topics and concepts, and results were compared using paired t-tests. For feedback on the speakers, participants were asked to submit their ratings measured on a five-point Likert scale. The reliability of the Likert scale was estimated using Cronbach's alpha. Analyses were performed using Microsoft Excel and SPSS version 23.

Results

In total, 52 individuals from different laboratories across Pakistan and Pakistani students from abroad (China) as well participated in at least one session of the IVT. The participants' pre- and post-test scores showed a significant increase in knowledge and awareness (p < 0.001). The obtained Cronbach's alpha score was >0.8, indicating high reliability of the generated feedback on the IVT approach and speakers.

Conclusion

The IVT on biosafety and biosecurity in the context of the COVID-19 pandemic proved beneficial for laboratory professionals and could be a useful model to continue in the future for raising awareness and knowledge.
Relation is an option for processing context information
Authors: Yamada Kazunori D , Baladram M. Samy , Lin Fangzhou
Published: October 2022

Attention mechanisms are one of the most frequently used architectures in the development of artificial intelligence because they can process contextual information efficiently. Various artificial intelligence architectures, such as Transformer for processing natural language, image data, etc., include the Attention. Various improvements have been made to enhance its performance since Attention is a powerful component to realize artificial intelligence. The time complexity of Attention depends on the square of the input sequence length. Developing methods to improve the time complexity of Attention is one of the most popular research topics. Attention is a mechanism that conveys contextual information of input sequences to downstream networks. Thus, if one wants to improve the performance of processing contextual information, the focus should not be confined only on improving Attention but also on devising other similar mechanisms as possible alternatives. In this study, we devised an alternative mechanism called “Relation” that can understand the context information of sequential data. Relation is easy to implement, and its time complexity depends only on the length of the sequences; a comparison of the performance of Relation and Attention on several benchmark datasets showed that the context processing capability of Relation is comparable to that of Attention but with less computation time. Processing contextual information at high speeds would be useful because natural language processing and biological sequence processing sometimes deal with very long sequences. Hence, Relation is an ideal option for processing context information.
Enactive explorations of children's sensory-motor play and therapeutic handling in physical therapy
Authors: Håkstad Ragnhild B. , Øberg Gunn Kristin , Girolami Gay L. , Dusing Stacey C.
Published: October 2022

Introduction

In pediatric physical therapy, there is an ongoing debate about the use of therapeutic handling and its potential effects on motor learning. In this study, we build on enactive theoretical perspectives to explore the role of therapeutic handling in connection to children's sensory-motor play, engagement, and performance during a single physical therapy session.

Material and methods

This is a qualitative study based on video observations of therapy sessions and interviews with 15 physical therapists (PTs) each treating two different children aged 0–3. The authors utilized a framework of co-reviewing, discussing, and reflecting on the sessions. Themes were identified and used to describe the ways by which PTs’ therapeutic handling unfolds, with connections to theories on sensory-motor play and learning, along with enactive perspectives on embodiment, experience, mutual incorporation, and sense-of-agency.

Results

The characteristics and purposes of therapeutic handling are presented in two main themes: (1) position and support, and (2) directing movement. We found that position and support promoted sensory-motor improvement when the PTs’ handling aligned with the child's play interests and engagements. As part of play, the children used new and additional support surfaces to self-initiate better posture and movement solutions and reach play goals. The PTs’ ways of directing movements varied. To awaken curiosity and induce a child's self-driven motor exploration the PT needs to be subtle, flexible, and precise in the directing of movement. This entails responsiveness to the child's signals and bodily know-how in the placing of hands and direction of pressure to enable the child to actively participate in and eventually self-drive movement.

Discussion

Therapeutic handling that is mutually incorporated between PT and child can enrich the child's playing-to-learn-to-move process by providing novelty and facilitating the child's sense-of-agency in the self-initiated exploration and refinement of movement possibilities. In the PTs’ effort to merge therapeutic handling with children's play, the momentum of interaction can open new therapeutic windows of movement experience and learning opportunities.
Simulation of a cholesteric blue phase cell with large but finite thickness
Authors: Fukuda Jun-ichi
Published: October 2022

We investigate the structure of a cholesteric blue phase (BP) liquid crystal cell of finite thickness under an electric field normal to the planar surfaces confining the liquid crystal. We carry out large scale simulations to consider cases in which the thickness of the BP liquid crystal is approximately 40 times the BP lattice constant (typical thickness in experiments), larger than that of previous simulation studies. Our calculations clearly demonstrate that the number of periodic structures along the thickness direction (thickness divided by the lattice constant) is discretized by the presence of confining surfaces. The stability of the so-called BP X structure over the BP I under the electric field, as well as the electrostriction, is confirmed. The metastability of the BP X structure after the cessation of the electric field, demonstrated in a recent experiment [Nat. Mater. 19, 94 (2020)] is also shown. We also perform calculations for the reflection spectra of the BP structures, and clearly observe the shift of the reflection peak due to electrostriction. Our study demonstrates the role of finite thickness on the behavior of a BP cell.
Resize Me! Exploring the user experience of embodied realistic modulatable avatars for body image intervention in virtual reality
Authors: Döllinger Nina , Wolf Erik , Mal David , Wenninger Stephan , Botsch Mario , Latoschik Marc Erich , Wienrich Carolin
Published: October 2022

Obesity is a serious disease that can affect both physical and psychological well-being. Due to weight stigmatization, many affected individuals suffer from body image disturbances whereby they perceive their body in a distorted way, evaluate it negatively, or neglect it. Beyond established interventions such as mirror exposure, recent advancements aim to complement body image treatments by the embodiment of visually altered virtual bodies in virtual reality (VR). We present a high-fidelity prototype of an advanced VR system that allows users to embody a rapidly generated personalized, photorealistic avatar and to realistically modulate its body weight in real-time within a carefully designed virtual environment. In a formative multi-method approach, a total of 12 participants rated the general user experience (UX) of our system during body scan and VR experience using semi-structured qualitative interviews and multiple quantitative UX measures. Using body weight modification tasks, we further compared three different interaction methods for real-time body weight modification and measured our system’s impact on the body image relevant measures body awareness and body weight perception. From the feedback received, demonstrating an already solid UX of our overall system and providing constructive input for further improvement, we derived a set of design guidelines to guide future development and evaluation processes of systems supporting body image interventions.
Climate change adaptation options to inform planning of agriculture and food systems in The Gambia: A systematic approach for stocktaking
Authors: Segnon Alcade C. , Zougmoré Robert B. , Green Rosemary , Ali Zakari , Carr Tony W. , Houessionon Prosper , M'boob Sulayman , Scheelbeek Pauline F. D.
Published: October 2022

Identifying and assessing adaptation options are key pre-requisite steps to adaptation prioritization and effective adaptation planning. In this paper, we presented a systematic approach for adaptation stocktaking, combining a systematic mapping and an outcome-oriented and evidence-based assessment, illustrated using the case of The Gambia. This study systematically mapped 24 adaptation options that can potentially inform adaptation planning in The Gambia agriculture and food systems and assessed how the identified options contribute to the pillars of Climate-Smart Agriculture. Because of the paucity of evidence sources from The Gambia, we collated evidence from both The Gambia and the West Africa region. We found that many of the documented options, such as climate-resilient crop varieties, crop diversification, climate information use, and weather indexed-based insurance have the potential to increase agricultural productivity and income while building resilience to climate change. While several options, such as soil and water conservation practices can positively contribute to climate change mitigation, others such as manure and inorganic fertilizers can have no or negative impacts on mitigation. Agroforestry practices and System of Rice Intensification have the potential to make a triple impact. The paucity of evidence from The Gambia and the highly contextual and differential impacts of the identified adaptation options underscore the importance of careful consideration of barriers and enablers when developing and deploying policy and interventions to sustainably increase productivity and income while building resilience to climate risks and reducing GHGs emissions. Stakeholder engagement and participatory research action are crucial in selecting and testing the priority adaptation options which can maximize their potentials in specific agricultural and food system contexts, such as in The Gambia. Because of the heterogeneity in household vulnerability and socioecological circumstances, targeting options to the right contexts will also be crucial to avoid maladaptation. We highlighted key knowledge gaps in the understanding of the effectiveness and feasibility of the identified adaptation options in The Gambia. Beyond The Gambia, the approach can also be useful for and replicated in other least developed countries in the West African region, that are currently developing their National Adaptation Plan.
Recurrent multifocal adult rhabdomyoma in an elderly woman diagnosed with Birt-Hogg-Dubé syndrome: A case report
Authors: Andersen Ulrik Ørsø , Rosenørn Marie Røsland , Homøe Preben
Published: October 2022

Birt-Hogg-Dubé syndrome (BHD) is a rare inherited autosomal dominant condition caused by a mutation in the tumor suppressor gene FLCN. This mutation predisposes the carrier to multiple pulmonary cysts, recurrent pneumothorax, renal tumors and benign skin tumors. Since the first description of BHD, additional clinical signs have been added to the syndrome and a large variety of benign tumors, such as rhabdomyomas (RM), have been linked with the FLCN gene mutation. RMs are rare tumors derived from striated muscle. The adult extracardiac rhabdomyoma occurs mostly in elderly patients, with a male predominance. It is most often located in the head and neck area and it has a potential of recurrence. We report a case of recurrent multifocal ARM in the oral cavity, present in an elderly woman with BHD and treated surgically. This could add support to RMs being linked to BHD.
Hyperkalemic cardiac arrest induced by mannitol administration during craniotomy: A case report and review of the literature
Authors: Zheng Hua , Cao Xueqin , Gao Feng , Li Xinhua , Wan Li , Luo Ailin
Published: October 2022

Introduction

Mannitol is the most widely used hyperosmolar agent during neurosurgical procedures. However, its use can lead to serious hyperkalemia with altered cardiac conduction.

Case presentation

Here we report a case in which a 40-min cardiac arrest was caused by mannitol-induced hyperkalemia during craniotomy. In addition, we conducted a literature review through a PubMed (MEDLINE) search of the relevant literature published so far. Details of all cases are presented and discussed. The results suggest that male patients or patients with uncontrolled diabetes might be at higher risk to develop this phenomenon. The results also suggest that the high dose and rapid rate of infusion of mannitol might contribute to mannitol-induced hyperkalemia.

Conclusion

Physicians should be aware of the existence of mannitol-induced hyperkalemia. Although the mechanism of this complication is not well established, it is prudent to administer mannitol cautiously, especially in patients with uncontrolled diabetes. Continuous electrocardiogram monitoring and frequent measurements of serum electrolytes can help to detect and treat possible life-threatening events induced by mannitol-induced hyperkalemia early.
Percutaneous fully endoscopic surgical management of the ruptured epidural catheter: Rescue of the novice anesthesiologist from his dilemma
Authors: Kong Weijun , Du Qian , Xin Zhijun , Cao Guangru , Liu Dexing , Wei Yiyong , Liao Wenbo
Published: October 2022

Background

Epidural nerve block and analgesia are basic anesthetic techniques for anesthesia. Epidural catheter rupture and partial retention are adverse events and rare complications of epidural catheterization technique. The probability of occurrence when applied by novice doctors is high. Removal of the residual catheter by conventional surgery causes more trauma and bleeding, slows recovery, and may causes medical disputes. We hypothesized that percutaneous spinal endoscopy a safe and effective remediation technique. This study was to analyze the efficacy and safety of removing the residual dural catheter by a percutaneous full-endoscopic technique(PFET) and discuss the clinical technique and precautions.

Methods

This was a retrospective analysis of 7 patients with ruptured epidural catheters treated in our department from October 2015 to October 2019 using the PFET to remove the remaining epidural catheter. The operation time, intraoperative bleeding volume, surgical complications, and neurological symptoms before and after surgery were recorded. The Self-Rating Anxiety Scale (SAS) was used to assess the anxiety level of the anesthesiologist and the patient before and after the catheter removal operation, and the postoperative low back pain VAS score was recorded.

Results

The remaining epidural catheter was successfully removed from all 7 patients. The operation time was 54.14 ± 14.45 (32–78) minutes, and the intraoperative blood loss was 9.134 ± 3.078 (5–15) ml. There were no cases of dural damage, cerebrospinal fluid leakage, sensorimotor dysfunction of the lower limbs, or bowel dysfunction. The anxiety symptoms of the patient and the anesthesiologist disappeared after removal of the residual epidural catheter. The patients' postoperative back pain VAS score was 0 to 2 points.

Conclusion

PFET is a safe and effective minimally invasive technique for removing residual epidural catheters. It causes less trauma and less bleeding, allows a faster recovery. It does not affect the recovery of patients from other surgical operations and reduces both medical risks and medical costs. At the same time, it avoids or reduces the occurrence of medical disputes and eliminates the pressure on novice anesthesiologists regarding similar adverse events.
Quality of life reporting in the management of posterior fossa tumours: A systematic review
Authors: Adegboyega Gideon , Jordan Chloe , Kawka Michal , Chisvo Nathan , Toescu Sebastian M. , Hill Ciaran
Published: October 2022

Introduction

Survival amongst posterior fossa tumour (PFT) patients is improving. Clinical endpoints such as overall survival fail to depict QoL. There is yet to be a review of current QoL instruments used for adult PFTs. Aim of this review is to outline the QoL reporting in the management of PFTs and measure participation level.

Methods

This systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis. A search strategy to identify adult patients with PFTs who took part in QoL metrics was conducted. Observational and experimental studies published from 1990 to date were included. Studies with a sample size less than 10 and performance measures such as Karnofsky Performance Status were not considered.

Results

A total of 116 studies were included in the final analysis. Vestibular schwannomas were the most common tumour pathology (n = 23,886, 92.6%) followed by pilocytic astrocytomas (n = 657, 2.5%) and meningiomas (n = 437, 1.7%) Twenty-five different QoL measures were used in the study pool. SF-36 was the most common (n = 55, 17 47.4%) QoL metric in the whole study pool, followed by the Penn Acoustic Neuroma QoL scale (n = 24, 20.7%) and Dizziness Handicap Inventory (n = 16, 13.8%). Seventy-two studies reported less-than 100% participation in QoL evaluation. The commonest reason for non-participation was a lack of response (n = 1,718, 60.8%), incomplete questionnaires (n = 268, 9.4%) and cognitive dysfunction (n = 258, 9.1%).

Conclusion

Informed clinical decision-making in PFT patients requires the development of specific QoL outcomes. Core outcome sets, and minimal clinically important differences (MCID) are essential for these metrics to show clinically significant improvements in patient QoL.
Risk factors for complications in elderly patients aged 85 years and over undergoing endoscopic biliary stone removal
Authors: Zhang Da-ya , Zhai Ya-qi , Zhang Guan-jun , Chen Sheng-xin , Wu Lang , Chen De-xin , Li Ming-yang
Published: October 2022

Background and aim

The number of elderly patients with biliary stones is increasing. Endoscopic retrograde cholangiography (ERCP) is considered to be an effective treatment for biliary stones. Having a sound knowledge of the risk factors can help reduce the incidence and severity of complications for ERCP. Furthermore, limited research has been published on patients aged over 85 years undergoing endoscopic biliary stone removal. This study aims to determine the risk factors that lead to complications of ERCP in patients over 85 years of age.

Methods

This was a single-center retrospective study. We analyzed 156 patients aged ≥ 85 years with biliary stones who underwent their first ERCP at Chinese PLA General Hospital from February 2002 to March 2021. Logistic regression models were employed to identify the independent risk factors for complications.

Results

A total of 13 patients (8.3%) had complications. Thereinto, pancreatitis, cholangitis, bleeding, and other complications occurred in 4 cases (2.6%), 1 cases (0.6%), 4 cases (2.6%), and 4 cases (2.6%), respectively. There was no perforation or death related to ERCP. Independent risk factors for complications were acute biliary pancreatitis (ABP) (P = 0.017) and Charlson Comorbidity Index (CCI) (P = 0.019). Significantly, reasons for incomplete stone removal at once were large stone (>10 mm) (P < 0.001) and higher acute physiology and chronic health evaluation scoring system (APACHE-II) (P = 0.005).

Conclusions

ERCP was recommended with caution in patients ≥ 85 years of age with ABP or higher CCI undergoing endoscopic biliary stone removal. In patients with ABP without cholangitis or biliary obstruction we recommend against urgent (within 48 h) ERCP. Patients with higher CCI who can tolerate ERCP can undergo rapid ERCP biliary stenting or nasobiliary implantation with later treatment of stones, and patients who cannot tolerate ERCP are treated promptly with PTCD and aggressive conservative treatment.
Modeling a Spheroidal Particle Ensemble and Inversion by Generalized Runge–Kutta Regularizers from Limited Data
Authors: Samaras Stefanos , Böckmann Christine , Ritter Christoph
Published: October 2022

Extracting information about the shape or size of non-spherical aerosol particles from limited optical radar data is a well-known inverse ill-posed problem. The purpose of the study is to figure out a robust and stable regularization method including an appropriate parameter choice rule to address the latter problem. First, we briefly review common regularization methods and investigate a new iterative family of generalized Runge–Kutta filter regularizers. Next, we model a spheroidal particle ensemble and test with it different regularization methods experimenting with artificial data pertaining to several atmospheric scenarios. We found that one method of the newly introduced generalized family combined with the L-curve method performs better compared to traditional methods.
Cell-Internal Contacting of Prismatic Lithium-Ion Batteries Using Micro-Friction Stir Spot Welding
Authors: Sigl Martina E. , Grabmann Sophie , Kick Luca-Felix , Zens Amanda , Hartl Roman , Zaeh Michael F.
Published: October 2022

The reliable production of high-quality lithium-ion battery components still poses a challenge, which must be met to cope with their rising demand. One key step in the production sequence is the process of cell-internal contacting, during which the electrode carrier foils of the anode and the cathode are joined with the arrester. This is usually done with ultrasonic or laser beam welding. Both joining processes, however, show limitations concerning the quality of the weld. This paper presents a new approach for cell-internal contacting by using micro-friction stir spot welding. Welding experiments were conducted in which joints with high mechanical strengths were produced. It was also shown that large stacks with foil numbers of 100 can be joined in only a few tenths of a second. The process is therefore especially of interest for the fast production of large-scale battery cells or other new types of high-energy-dense battery cells.
Electron-Beam Synthesis and Modification and Properties of Boron Coatings on Alloy Surfaces
Authors: Yushkov Yury , Oks Efim , Kazakov Andrey , Tyunkov Andrey , Zolotukhin Denis
Published: October 2022

In this study, fore-vacuum plasma electron beam sources were used to deposit a few micron-thick boron coatings on A284 and ZrNb1 alloys and modify their surfaces. The coating deposition rate with a continuous 1 kW electron beam that evaporated the boron target at a distance of 10 cm was 0.5 µm/min, and the boron coating density was 2.2 g/cm3. Based on the comparison of data on the mass-to-charge composition, beam plasma density, and coating parameters, the contribution of the plasma phase of the evaporated material to the growth of coatings was greater than that of the vapor phase. Using the scanning electron and atomic force microscopy techniques, surface modification by repeated electron beam pulses with electron energies of 8 and 6 keV and a beam power per pulse of 2 J/cm2 and 2.25 J/cm2, respectively, transformed a relatively smooth coating surface into a hilly structure. Based on a structural phase analysis of coatings using synchrotron radiation, it was concluded that the formation of the hilly coating structure was due to surface melting under the repeated action of electron beam pulses. The microhardness, adhesion, and wear resistance of coatings were measured, and their corrosion tests are presented herein. The pure boron coatings obtained and studied are expected to be of use in various applications.
Heat-Induced Proteotoxic Stress Response in Placenta-Derived Stem Cells (PDSCs) Is Mediated through HSPA1A and HSPA1B with a Potential Higher Role for HSPA1B
Authors: Alharbi Bothina Mohammed , Bugshan Aisha , Almozel Azhaar , Alenzi Reem , Bouchama Abderrezak , Khatlani Tanvir , Mohammad Sameer , Malik Shuja Shafi
Published: October 2022

Placenta-derived stem cells (PDSCs), due to unique traits such as mesenchymal and embryonic characteristics and the absence of ethical constraints, are in a clinically and therapeutically advantageous position. To aid in stemness maintenance, counter pathophysiological stresses, and withstand post-differentiation challenges, stem cells require elevated protein synthesis and consequently augmented proteostasis. Stem cells exhibit source-specific proteostasis traits, making it imperative to study them individually from different sources. These studies have implications for understanding stem cell biology and exploitation in the augmentation of therapeutic applications. Here, we aim to identify the primary determinants of proteotoxic stress response in PDSCs. We generated heat-induced dose-responsive proteotoxic stress models of three stem cell types: placental origin cells, the placenta-derived mesenchymal stem cells (pMSCs), maternal origin cells, the decidua parietalis mesenchymal stem cells (DPMSCs), and the maternal–fetal interface cells, decidua basalis mesenchymal stem cells (DBMSCs), and measured stress induction through biochemical and cell proliferation assays. RT-PCR array analysis of 84 genes involved in protein folding and protein quality control led to the identification of Hsp70 members HSPA1A and HSPA1B as the prominent ones among 17 significantly expressed genes and with further analysis at the protein level through Western blotting. A kinetic analysis of HSPA1A and HSPA1B gene and protein expression allowed a time series evaluation of stress response. As identified by protein expression, an active stress response is in play even at 24 h. More prominent differences in expression between the two homologs are detected at the translational level, alluding to a potential higher requirement for HSPA1B during proteotoxic stress response in PDSCs.
The Safe Campus Project— Resilience of Academic Institutions during the COVID-19 Crisis
Authors: Schneider Matthias F. , Dohmen Lukas , Hanisch Daniel T. , Haider Gregor , Gruhn Andreas
Published: October 2022

In this study, we describe how to keep a campus safe and “open” by implementing a proactive, as opposed to reactive, strategy (the Green Zone strategy). The pillars are leadership, clear communication, clean air, vaccination campaigns, and intense efforts in mass testing. Over a period of 12 months, about 277,000 pooled real-time polymerase chain reaction (RT-PCR) samples and lateral flow tests (LFTs) were collected, and 201 people were identified as COVID-19-positive. For the PCRs, we use the Lollipop technique, combined with nose swabs and gargle samples, to minimize sample-collection efforts. Importantly, not only staff, students, and contractors, but also their family members, friends, and partners; daycare centers; and local sports and arts teams, etc., were invited and participated. This outreach made it possible to propagate the tests more widely and monitor a larger network. At times of larger social gatherings—most prominently, on 23 December 2021 before Christmas (during the rise of the Omicron wave)—testing capacities were increased. The results not only demonstrate the great power of mass testing in providing an open-but-safe work environment, even if the surroundings are highly infectious (red zone), but also the strength and resilience of a university. It shows how the unique pillars of science, infrastructure, students, and independency make it possible to maneuver a community, even through unpredictable times.
Elliptical Multi-Orbit Circumnavigation Control of UAVS in Three-Dimensional Space Depending on Angle Information Only
Authors: Wang Zhen , Luo Yanhong
Published: October 2022

In order to analyze the circumnavigation tracking problem in complex three-dimensional space, in this paper, we propose a UAV group circumnavigation control strategy, in which the UAV circumnavigation orbit is an ellipse whose size can be adjusted arbitrarily; at the same time, the UAV group can be assigned to multiple orbits for tracking. The UAVs only have the angle information of the target, and the position information of the target can be obtained by using the angle information and the proposed three-dimensional estimator, thereby establishing an ideal relative velocity equation. By constructing the error dynamic equation between the actual relative velocity and the ideal relative velocity, the circumnavigation problem in three-dimensional space is transformed into a velocity tracking problem. Since the UAVs are easily disturbed by external factors during flight, the sliding mode control is used to improve the robustness of the system. Finally, the effectiveness of the control law and its robustness to unexpected situations are verified by simulation.
Crystal Structure Optimization with Deep-Autoencoder-Based Intrusion Detection for Secure Internet of Drones Environment
Authors: Alissa Khalid A. , Alotaibi Saud S. , Alrayes Fatma S. , Aljebreen Mohammed , Alazwari Sana , Alshahrani Hussain , Ahmed Elfaki Mohamed , Othman Mahmoud , Motwakel Abdelwahed
Published: October 2022

Drone developments, especially small-sized drones, usher in novel trends and possibilities in various domains. Drones offer navigational inter-location services with the involvement of the Internet of Things (IoT). On the other hand, drone networks are highly prone to privacy and security risks owing to their strategy flaws. In order to achieve the desired efficiency, it is essential to create a secure network. The purpose of the current study is to have an overview of the privacy and security problems that recently impacted the Internet of Drones (IoD). An Intrusion Detection System (IDS) is an effective approach to determine the presence of intrusions in the IoD environment. The current study focuses on the design of Crystal Structure Optimization with Deep-Autoencoder-based Intrusion Detection (CSODAE-ID) for a secure IoD environment. The aim of the presented CSODAE-ID model is to identify the occurrences of intrusions in IoD environment. In the proposed CSODAE-ID model, a new Modified Deer Hunting Optimization-based Feature Selection (MDHO-FS) technique is applied to choose the feature subsets. At the same time, the Autoencoder (AE) method is employed for the classification of intrusions in the IoD environment. The CSO algorithm, inspired by the formation of crystal structures based on the lattice points, is employed at last for the hyperparameter-tuning process. To validate the enhanced performance of the proposed CSODAE-ID model, multiple simulation analyses were performed and the outcomes were assessed under distinct aspects. The comparative study outcomes demonstrate the superiority of the proposed CSODAE-ID model over the existing techniques.
Deep Reinforcement Learning Based Decision Making for Complex Jamming Waveforms
Authors: Xu Yuting , Wang Chao , Liang Jiakai , Yue Keqiang , Li Wenjun , Zheng Shilian , Zhao Zhijin
Published: October 2022

With the development of artificial intelligence, intelligent communication jamming decision making is an important research direction of cognitive electronic warfare. In this paper, we consider a complex intelligent jamming decision scenario in which both communication parties choose to adjust physical layer parameters to avoid jamming in a non-cooperative scenario and the jammer achieves accurate jamming by interacting with the environment. However, when the situation becomes complex and large in number, traditional reinforcement learning suffers from the problems of failure to converge and a high number of interactions, which are fatal and unrealistic in a real warfare environment. To solve this problem, we propose a deep reinforcement learning based and maximum-entropy-based soft actor-critic (SAC) algorithm. In the proposed algorithm, we add an improved Wolpertinger architecture to the original SAC algorithm in order to reduce the number of interactions and improve the accuracy of the algorithm. The results show that the proposed algorithm shows excellent performance in various scenarios of jamming and achieves accurate, fast, and continuous jamming for both sides of the communication.
Information Flow in Biological Networks for Color Vision
Authors: Malo Jesús
Published: October 2022

Biological neural networks for color vision (also known as color appearance models) consist of a cascade of linear + nonlinear layers that modify the linear measurements at the retinal photo-receptors leading to an internal (nonlinear) representation of color that correlates with psychophysical experience. The basic layers of these networks include: (1) chromatic adaptation (normalization of the mean and covariance of the color manifold); (2) change to opponent color channels (PCA-like rotation in the color space); and (3) saturating nonlinearities to obtain perceptually Euclidean color representations (similar to dimension-wise equalization). The Efficient Coding Hypothesis argues that these transforms should emerge from information-theoretic goals. In case this hypothesis holds in color vision, the question is what is the coding gain due to the different layers of the color appearance networks? In this work, a representative family of color appearance models is analyzed in terms of how the redundancy among the chromatic components is modified along the network and how much information is transferred from the input data to the noisy response. The proposed analysis is performed using data and methods that were not available before: (1) new colorimetrically calibrated scenes in different CIE illuminations for the proper evaluation of chromatic adaptation; and (2) new statistical tools to estimate (multivariate) information-theoretic quantities between multidimensional sets based on Gaussianization. The results confirm that the efficient coding hypothesis holds for current color vision models, and identify the psychophysical mechanisms critically responsible for gains in information transference: opponent channels and their nonlinear nature are more important than chromatic adaptation at the retina.
Maximum Efficient Power Performance Analysis and Multi-Objective Optimization of Two-Stage Thermoelectric Generators
Authors: Tian Lei , Chen Lingen , Ge Yanlin , Shi Shuangshuang
Published: October 2022

Two-stage thermoelectric generators have been widely used in the aerospace, military, industrial and daily life fields. Based on the established two-stage thermoelectric generator model, this paper further studies its performance. Applying the theory of finite-time thermodynamics, the efficient power expression of the two-stage thermoelectric generator is deduced firstly. The maximum efficient power is obtained secondly by optimizing the distribution of the heat exchanger area, distribution of thermoelectric elements and working current. Using the NSGA-II algorithm, multi-objective optimizations of the two-stage thermoelectric generator are performed thirdly by taking the dimensionless output power, thermal efficiency and dimensionless efficient power as objective functions, and taking the distribution of the heat exchanger area, distribution of thermoelectric elements and output current as optimization variables. The Pareto frontiers with the optimal solution set are obtained. The results show that when the total number of thermoelectric elements is increased from 40 to 100, the maximum efficient power is decreased from 0.308W to 0.2381W. When the total heat exchanger area is increased from 0.03m2 to 0.09m2, the maximum efficient power is increased from 0.0603W to 0.3777W. The deviation indexes are 0.1866, 0.1866 and 0.1815 with LINMAP, TOPSIS and Shannon entropy decision-making approaches, respectively, when multi-objective optimization is performed on three-objective optimization. The deviation indexes are 0.2140, 0.9429 and 0.1815 for three single-objective optimizations of maximum dimensionless output power, thermal efficiency and dimensionless efficient power, respectively.
Weighted Cumulative Past Extropy and Its Inference
Authors: Kazemi Mohammad Reza , Hashempour Majid , Longobardi Maria
Published: October 2022

This paper introduces and studies a new generalization of cumulative past extropy called weighted cumulative past extropy (WCPJ) for continuous random variables. We explore the following: if the WCPJs of the last order statistic are equal for two distributions, then these two distributions will be equal. We examine some properties of the WCPJ, and a number of inequalities involving bounds for WCPJ are obtained. Studies related to reliability theory are discussed. Finally, the empirical version of the WCPJ is considered, and a test statistic is proposed. The critical cutoff points of the test statistic are computed numerically. Then, the power of this test is compared to a number of alternative approaches. In some situations, its power is superior to the rest, and in some other settings, it is somewhat weaker than the others. The simulation study shows that the use of this test statistic can be satisfactory with due attention to its simple form and the rich information content behind it.
Energetic and Economic Performances of the Energy Community of Magliano Alpi after One Year of Piloting
Authors: Ghiani Emilio , Trevisan Riccardo , Rosetti Gian Luca , Olivero Sergio , Barbero Luca
Published: October 2022

Italy’s first renewable energy community, located in the municipality of Magliano Alpi, was established under Italian Law 8/2020 on Energy Communities in December 2020. The community is composed of eight stakeholders and involves, in addition to public buildings in the municipality of Magliano Alpi, some residential users and small and medium-sized enterprises, realizing public–private cooperation aimed at reducing energy dependence on the public grid and, at the same time, contributing to the decarbonization of the energy sector. This article provides an analysis of the economic and energy performance during the first year of renewable community piloting. The study analyzes data collected with the community energy management system and introduces a number of key performance indices useful for evaluating further development and optimization options.
Suppression of Wind Generator Speed Vibration Based on the Internal Model Control with Three Degrees of Freedom
Authors: Zhou Chenyang , Shen Yanxia
Published: October 2022

When the wind power system is working in the maximum wind energy tracking area, or when its mechanical drivetrain system vibrates and the vibration frequency is relatively high, the system cannot suppress the speed vibration of the generator in the drivetrain system by adjusting the pitch angle. In this paper, a generator speed control system based on the three degrees of freedom internal model control (3-DOF-IMC) is established to control the generator speed. Thus, a scheme of using the feedback filter in the 3-DOF-IMC to suppress generator speed vibration caused by drivetrain shaft elasticity and gear clearance in the drivetrain system is proposed. Firstly, the vibration problem and waveform of the two-mass wind power drivetrain systems are discussed, and the generator’s vector control and speed control systems are analyzed. Secondly, the principle of the 3-DOF-IMC is described, and the influence of the three controllers on the speed tracking performance and anti-interference performance of the generator is discussed. The suppression ability of the feedback filter for different forms of disturbance signals is emphasized. Finally, the feedback filter controls the generator speed and eliminates the influence of drivetrain vibration on the generator speed. To verify the superiority of the proposed method, the vibration suppression effect, tracking performance and anti-interference performance of the proposed method are compared with the engineering design method (EDM) and conventional IMC (1-DOF-IMC) method. When the parameter α/β = 0.66, the generator speed amplitude overshoot of the proposed method is the same as the EDM. When α/β = 1, it is only 4% of the amplitude overshoot of the EDM. In addition, the tracking performance and anti-interference performance of the proposed method can be adjusted independently, and it is better than the EDM and the 1-DOF-IMC method.
Decadal Changes in the Annual Growth of Two Commercial Ommastrephid Species in the Pacific Ocean
Authors: Han Peiwu , Li Jianhua , Dan Yating , Liu Bilin , Chen Xinjun , Fang Zhou
Published: October 2022

Neon flying squid Ommastrephes bartramii and jumbo flying squid Dosidicus gigas are two important commercial ommastrephid species in the Pacific Ocean. As short-lived marine species, squids are highly susceptible to changes in climate and marine environments. According to samples collected from the northwest and southeast Pacific Ocean in different years, we explored the growth characteristics of these two squids in terms of their mantle length (ML) distribution and the relationship between mantle length and body weight (LWR), also considering the relative condition factors (Kn), and explored the effects of the El Niño and Southern Oscillation (ENSO) on their growth. The results showed that the ML for O. bartramii and D. gigas had significant differences among different years and different sexes (p < 0.01), and the size of females was larger than that of males. LWR showed that both squids demonstrated a positive allometric growth pattern (b > 3), and parameters a and b were influenced by year and sex. Furthermore, there were significant differences in Kn in both squids for different years and different sexes (p < 0.01), and their interannual fluctuations were quite significant. In conclusion, the alterations in the marine environment caused by climate change had a significant impact on the growth of O. bartramii and D. gigas in this study. ENSO events had opposite effects on the growth of both squid species.