bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between inflammatory bowel disease and frailty: a two-sample Mendelian randomization study
Authors: Feng Jingyi , Chen Xi , Cai Wenjing , Zhou Xueying , Zhang Xuefang
Published: February 2024

Background

An association has been identified between inflammatory bowel disease (IBD) and frailty; however, the causal nature of this connection remains uncertain. We consequently conducted a two-sample Mendelian randomization (MR) analysis to explore this particular association.

Methods

We acquired distinct datasets for inflammatory bowel disease (IBD), Crohn's disease (CD), ulcerative colitis (UC), and frailty from the published genome-wide association studies (GWAS) database, meticulously selecting instrumental variables (IVs). Subsequently, we employed a bidirection MR to examine the causal relationship between IBD (including CD and UC) and frailty. We utilized statistical methods, with a primary emphasis on inverse-variance weighted (IVW), accompanied by a series of sensitivity analyses to confirm heterogeneity and pleiotropy influenced the outcomes of the MR.

Results

We found positive causal effects of genetically increased frailty risk on IBD (OR: 1.015, 95% CI 1.005–1.025, P = 0.004). Furthermore, when scrutinizing specific IBD subtypes, both Crohn's disease (CD) and ulcerative colitis (UC) demonstrated an increased predisposition to frailty (OR: 1.018, 95% CI 1.01–1.027, P < 0.05) and (OR = 1.016, 95% CI 1.005–1.027, P < 0.05). Nevertheless, despite the consistent trends observed in the weighted median and MR-Egger regression analyses for both conditions, statistical significance remained elusive. Notably, the results of the inverse MR analysis did not establish an association between frailty and an elevated risk of IBD development.

Conclusions

Our research indicates that IBD, encompassing both CD and UC, may augment the propensity for frailty. Clinical practitioners must prioritize early frailty assessment in individuals afflicted with inflammatory bowel disease, inclusive of Crohn's disease and ulcerative colitis, facilitating proactive measures and timely interventions. However, our findings do not provide evidence supporting a causal effect of frailty on IBD (including CD and UC). Consequently, further studies are essential to explore the intricate mechanisms that clarify the effect of frailty on IBD.
Social Meritocracy and Unjust Social Hierarchies: Three Proposals to Limit Meritocracy’s Erosion of Social Cooperation
Authors: Ziliotti Elena
Published: February 2024

A well-functioned society depends on its ability to nurture, attract, and deploy talents in critical sectors. However, the implementation of some meritocratic principles to allocate positions often leads to unjust social hierarchies. Is there, then, a solution to meritocracy’s dysfunctional hierarchical effects? This paper attempts to answer this by drawing on the real-world cases of Singapore and the USA to investigate the relationship of toxic social hierarchies with meritocracy. It proposes three solutions to curb the unjustifiable social stratifications and the erosion of social cooperation often associated with social meritocracy. These reflections could help to shed light on the grounds for the ongoing debates on social hierarchies and provide valuable insights into how to weigh up existing socio-political structures.
Seeing with Different Eyes. The Module Life & Science of the Elite-Master Program Biomedical Neuroscience
Authors: Schumm Moritz , Teufel Daniel , Brunnhuber Michael , Wijnen-Meijer Marjo , Berberat Pascal O.
Published: February 2024

From its beginnings in 2018, the international elite-master program Biomedical Neuroscience of TUM School of Medicine and Health at Technical University of Munich was guided by two convictions: First, excellent research depends not only on the mediation of scientific knowledge and skills, but also on a multifaceted understanding of science itself. Second, teaching must recognize and support not only student’s growing expertise but also their personal and professional development. To this end, the module Life & Science was designed. It gives students the opportunity to explore neuroscience from different angles to deepen the epistemological, sociological, and cultural understanding of their chosen profession.
Efficient Top-k Frequent Itemset Mining on Massive Data
Authors: Wan Xiaolong , Han Xixian
Published: February 2024

Top-k frequent itemset mining (top-k FIM) plays an important role in many practical applications. It reports the k itemsets with the highest supports. Rather than the subtle minimum support threshold specified in FIM, top-k FIM only needs the more understandable parameter of the result number. The existing algorithms require at least two passes of scan on the table, and incur high execution cost on massive data. This paper develops a prefix-partitioning-based PTF algorithm to mine top-k frequent itemsets efficiently, where each prefix-based partition keeps the transactions sharing the same prefix item. PTF can skip most of the partitions directly which cannot generate any top-k frequent itemsets. Vertical mining is developed to process the partitions of vertical representation with the high-support-first principle, and only a small fraction of the items are involved in the processing of the partitions. Two improvements are proposed to reduce execution cost further. Hybrid vertical storage mode maintains the prefix-based partitions adaptively and the candidate pruning reduces the number of the explored candidates. The extensive experimental results show that, on massive data, PTF can achieve up to 1348.53 times speedup ratio and involve up to 355.31 times less I/O cost compared with the state-of-the-art algorithms.
DGS1 improves rice disease resistance by elevating pathogen-associated molecular pattern-triggered immunity
Authors: Wang Yu , Zheng Chuan , Peng You-liang , Chen Qian
Published: February 2024

Rice yield and disease resistance are two crucial factors in determining the suitability of a gene for agricultural breeding. Decreased grain size1 (DGS1), encoding an RING-type E3 ligase, has been found to have a positive effect on rice yield by regulating rice grain number and 1000-grain weight. However, the role of DGS1 in rice blast resistance is still unknown. In this study, we report that DGS1 enhances disease resistance by improving PTI responses, including stronger ROS burst and MAPK activation, and also increased expression of defense-related genes. Furthermore, DGS1 works in conjunction with ubiquitin conjugating enzyme OsUBC45 as an E2–E3 pair to facilitate the ubiquitin-dependent degradation of OsGSK3 and OsPIP2;1, thereby influencing rice yield and immunity, respectively. Therefore, the DGS1-OsUBC45 module has the potential in facilitating rice agricultural breeding.
Intersections of ultracold atomic polarons and nuclear clusters: how is a chart of nuclides modified in dilute neutron matter?
Authors: Tajima Hiroyuki , Moriya Hajime , Horiuchi Wataru , Nakano Eiji , Iida Kei
Published: February 2024

Neutron star observations, as well as experiments on neutron-rich nuclei, used to motivate one to look at degenerate nuclear matter from its extreme, namely, pure neutron matter. As an important next step, impurities and clusters in dilute neutron matter have attracted special attention. In this paper, we review in-medium properties of these objects on the basis of the physics of polarons, which have been recently realized in ultracold atomic experiments. We discuss how such atomic and nuclear systems are related to each other in terms of polarons. In addition to the interdisciplinary understanding of in-medium nuclear clusters, it is shown that the quasiparticle energy of a single proton in neutron matter is associated with the symmetry energy, implying a novel route toward the nuclear equation of state from the neutron-rich side.
Structure–activity relationships over Ru/NiAl2O4 catalysts in anisole demethoxylation: spectroscopic and kinetic studies
Authors: Li Lingxiao , Guo Zhiruo , Liu Xiaohui , Shakouri Mohsen , Hu Yongfeng , Guo Yong , Wang Yanqin
Published: February 2024

Demethoxylation  was kinetically and spectroscopically studied over three catalysts with different Ru0/Ruδ+ ratios. In-situ spectroscopic tests demonstrated that the synergy between Ru0 and Ruδ+ was crucial, and Ru0 was in charge of H2 activation and adsorption of aromatic ring while Ruδ+ adsorbed with O in methoxyl. A Langmuir–Hinshelwood kinetic model was proposed, and ratio of Ru0/Ruδ+ was the key in deciding the rate-determining step (RDS): i) desorption of toluene was RDS over catalyst with high Ru0 ratio; ii) dissociation of H2 was RDS over Ruδ+ enriched catalyst; iii) demethoxylation was rate-determined by CO water–gas shift (WGS) when Ru0/Ruδ+ approached ~ 1. The best performance was obtained over Ru/NiAl2O4-200, which effectively enabled both C-O bond activation and rapid recovery of adsorption sites for aromatic rings. Finally, in-situ DRIFT studies on methoxy decomposition and CO-WGS unraveled that the electronic composition of Ru was more stable in Ru/NiAl2O4-200 which contributes to its excellence.
Changes in the neutrophil-to-lymphocyte ratio (NLR) as predictive values for metastatic gastric cancer patients with PD-1 inhibitors
Authors: Gou Miaomiao , Zhang Yong , Wang Zhikuan , Qian Niansong
Published: February 2024

Background

The combination of immunotherapy and chemotherapy can improve the survival of metastatic gastric cancer (MGC) patients based on checkmate 649 and Orential 16. The neutrophil-to-lymphocyte ratio (NLR) in the pretreatment period can be used as a prognostic indicator in patients receiving immune checkpoint inhibitors (ICIs) to treat different cancers. However, no study has yet explored the relationships between NLR changes during PD-1 treatment and patient survival.

Method

First, we enrolled patients diagnosed with MGC under anti-PD-1-based treatments from October 1st, 2015 to December 31st, 2020 at the Chinese PLA General Hospital. These patients were stratified regarding their baseline NLR and variants of NLR. Then we explored the association between relative NLR changes and other clinical features with the overall survival (OS) and progression-free survival (PFS) of patients treated with immunotherapy using multivariate Cox analysis.

Results

A total of 137 patients were enrolled in the present study. We categorized patients into decreased (ΔNLR < 0) and increased (ΔNLR ≥ 0) post-treatment NLR groups. The median OS and PFS were 12.3 months and 7.8 months for patients with ΔNLR < 0, respectively, compared to 7.5 months and 4.3 months for patients with ΔNLR ≥ 0 (both p < 0.05). The ORR was 41.8% in the ΔNLR < 0 group, higher than the ΔNLR ≥ 0 group (ORR = 24.3%). Patients with both NLR ≥ 3.23 and ΔNLR ≥ 0 had a significantly increased risk of death (HR: 2.349, 95% CI: 1.701 – 3.243, p < 0.001) and disease progression (HR: 2.297, 95% CI: 1.666 – 3.167, p < 0.001) compared to patients with NLR < 3.23 and ΔNLR < 0. Patients with either NLR ≥ 3.23 or ΔNLR ≥ 0 showed an intermediate risk of death (HR: 2.626, 95% CI: 1.660 – 4.155, p < 0.001) and progression (HR: 2.554, 95% CI: 1.590 – 4.101, p < 0.001). The ORR (50.0%) and DCR (91.2%) was higher in the NLR < 3.23 and ΔNLR < 0 group compared to other combination groups (both p < 0.05).

Conclusion

The combination of NLR changes after anti-PD-1 treatment with the baseline NLR was significantly correlated with patient survival and could be used to categorize patients into high- and low-risk groups. Finally, prospectively designed clinical trials are required to substantiate our current findings.
Drawing a blank – design modelling composite timber elements
Authors: Svilans Tom , Thomsen Mette Ramsgaard
Published: February 2024

The shift towards bio-economies of architectural fabrication necessitates particular consideration of how characterizing aspects of bio-materials such as heterogeneity and anisotropy impact the designed performance of architectural elements. These aspects must be integrated into the modelling and representation of architecture and must be instrumentalised for digital design and fabrication processes. The use of timber in construction is challenging due to its complex material behaviours, and therefore robust methods for predicting and modelling these are crucial for exploiting the timber resource more effectively. In light of this, we focus on developing a holistic and integrated digital modelling approach for glue-laminated timber construction elements that connects the digital design model to the specific material resource and incorporates its material complexity into design simulation workflows. We question the role of the lamella in the glulam blank and trace its agency through a series of four disparate projects, from an initially silent and generic constituent of the blank to a key, operative actor in the design of performance-graded timber products through the added specificity of material composition and a liberation of its form. The first project develops a modelling approach that connects material specification and lamella sizing to free-form timber element geometries. It uses principles of industrial glulam production and knowledge of the anisotropic nature of timber to speculate on new forms of glulam blanks that could arise from a deeper engagement with the glue-lamination process. The second project looks further back in the timber value chain at the processing of the specific forest resource into tailored building elements, attaching a material specificity to the lamella. The third project expands the modelling and prototyping of non-standard glulam blanks into considerations of timber waste streams and aesthetics. The final project aims to further speciate the lamella by tailoring its form as well as its material composition to respond to simulated performance demands. Through these projects we outline the development of a novel digital framework that begins as a modelling approach for free-form glulam beams and grows to accommodate the mapping and allocation of specific, heterogeneous input material. As the digital framework matures, increasingly detailed and interlinked digital simulations of mechanical performance are integrated.
A review of intraoperative protective ventilation
Authors: Zou Yuanyuan , Liu Zhiyun , Miao Qing , Wu Jingxiang
Published: February 2024

Mechanical ventilation is an important life-saving therapy for general anesthesia and critically ill patients, but ventilation itself may be accompanied with lung injury. Ventilator-induced lung injury (VILI) exacerbates pre-existing lung disease, leading to poor clinical outcomes. Especially for patients undergoing cardiothoracic surgery and receiving one-lung ventilation (OLV), optimizing the parameters of OLV is closely related to their prognosis. It is not clear what is the best strategy to minimize VILI through adjusting ventilation parameters, including tidal volume, positive end expiratory pressure and driving pressure, etc. Different parameters, in combination, are responsible for VILI. Protective ventilation strategies, aiming to reduce postoperative pulmonary complications, have been discussed in many clinical studies and different opinions have been raised. This review addresses the pathogenesis of VILI and focus on the OLV management and better protective OLV strategies during thoracic surgery.
Applied Cognitive Linguistics and L2 Instruction
Authors: Llopis-García Reyes
Published: February 2024

Both applied cognitive linguistics (ACL) researchers and linguists, and language instructors and professionals looking for a comprehensive and innovative access to ACL from the direct point of view of applied L2 Pedagogy, will find this Element to be of interest. There is great demand for quality teaching materials, a need for guidance on how to design them and which technology tools are of value. This Element takes a theoretical approach to that design while offering direct examples and tips for practitioners and researchers. Questions about empirical studies are explored, probing prominent empirical research, and the author provides promising evidence to support their recommendations on assetment-task design for future research. Linguists, researchers, linguistics students, graduate academic programs, and teachers of L2 languages alike will find value in this Element.
Public Inquiries and Policy Design
Authors: Stark Alastair , Yates Sophie
Published: February 2024

Public inquiries regularly produce outcomes of importance to policy design. However, the policy design literature has largely ignored the many important ways that public inquiries can act as policy design tools, meaning the functions that inquiries can offer the policy designer are not properly understood. This Element addresses this gap in two ways. First, it presents a theoretical discussion, underpinned by international empirical illustrations, to explain how inquiries perform policy design roles and can be classified as procedural policy tools. It focuses on four inquiry functions – catalytic, learning, processual, and legitimation. Second, it addresses the challenge of designing inquiries that have the policy-facing capacities required to make them effective. It introduces plurality as a key variable influencing effectiveness, demonstrating its relevance to internal inquiry operations, the external inquiry environment, and policy tool selection. Thus, it combines conceptual and practical insights to speak to academic and practice orientated audiences.
Comparing local energy cascade rates in isotropic turbulence using structure-function and filtering formulations
Authors: Yao Hanxun , Schnaubelt Michael , Szalay Alexander S. , Zaki Tamer A. , Meneveau Charles
Published: February 2024

Two common definitions of the spatially local rate of kinetic energy cascade at some scale

$\ell$

in turbulent flows are (i) the cubic velocity difference term appearing in the ‘scale-integrated local Kolmogorov–Hill’ equation (structure-function approach), and (ii) the subfilter-scale energy flux term in the transport equation for subgrid-scale kinetic energy (filtering approach). We perform a comparative study of both quantities based on direct numerical simulation data of isotropic turbulence at Taylor-scale Reynolds number 1250. While in the past observations of negative subfilter-scale energy flux (backscatter) have led to debates regarding interpretation and relevance of such observations, we argue that the interpretation of the local structure-function-based cascade rate definition is unambiguous since it arises from a divergence term in scale space. Conditional averaging is used to explore the relationship between the local cascade rate and the local filtered viscous dissipation rate as well as filtered velocity gradient tensor properties such as its invariants. We find statistically robust evidence of inverse cascade when both the large-scale rotation rate is strong and the large-scale strain rate is weak. Even stronger net inverse cascading is observed in the ‘vortex compression’

$R>0$

,

$Q>0$

quadrant, where

$R$

and

$Q$

are velocity gradient invariants. Qualitatively similar but quantitatively much weaker trends are observed for the conditionally averaged subfilter-scale energy flux. Flow visualizations show consistent trends, namely that spatially, the inverse cascade events appear to be located within large-scale vortices, specifically in subregions when

$R$

is large.
Covering convection with a thermal blanket: numerical simulation and stochastic modelling
Authors: Huang Jinzi Mac
Published: February 2024

Adding moving boundaries to convective fluids is known to result in non-trivial and surprising dynamics, leading to spectacular geoformations ranging from kilometre-scale karst terrains to planetary-scale plate tectonics. On the one hand, the moving solid alters the surrounding flow field, but on the other hand, the flow modifies the motion and shape of the solid. This leads to a two-way coupling that is significant in the study of fluid–structure interactions and in the understanding of geomorphologies. In this work, we investigate the coupling between a floating plate and the convective fluid below it. Through numerical experiments, we show that the motion of this plate is driven by the flow beneath. However, the flow structure is also modified by the presence of the plate, leading to the ‘thermal blanket’ effect where the trapped heat beneath the plate results in buoyant and upwelling flows that in turn push the plate away. By analysing this two-way coupling between moving boundary and fluid, we are able to capture the dynamical behaviours of this plate through a low-dimensional stochastic model. Geophysically, the thermal blanket effect is believed to drive the continental drift, therefore understanding this mechanism has significance beyond fluid dynamics.
Sum-frequency triad interactions among surface waves propagating through an ice sheet
Authors: Pierce Max W. , Liu Yuming , Yue Dick K.P.
Published: February 2024

We study nonlinear resonant wave–wave interactions which occur when ocean waves propagate into a thin floating ice sheet. Using multiple-scale perturbation analysis, we obtain theoretical predictions of the wave amplitude evolution as a function of distance travelled past the ice edge for a semi-infinite ice sheet. The theoretical predictions are supported by a high-order spectral (HOS) method capable of simulating nonlinear interactions in both open water and the ice sheet. Using the HOS method, the amplitude evolution predictions are extended to multiple (coupled) triad interactions and a single ice sheet of finite length. We relate the amplitude evolution to mechanisms with strong frequency dependence – ice bending strain, related to ice breakup, as well as wave reflection and transmission. We show that, due to sum-frequency interactions, the maximum strain in the ice sheet can be more than twice that predicted by linearised theory. For an ice sheet of finite length, we show that nonlinear wave reflection and transmission coefficients depend on a parameter in terms of wave steepness and ice length, and can have values significantly different than those from linear theory. In particular, we show that nonlinear sum-frequency interactions can appreciably decrease the total wave energy transmitted past the ice sheet. This work has implications for understanding the occurrence of ice breakup, wave attenuation due to scattering in the marginal ice zone and the resulting ice floe size distribution.
BETWEENNESS ALGEBRAS
Authors: DÜNTSCH IVO , GRUSZCZYŃSKI RAFAŁ , MENCHÓN PAULA
Published: February 2024

We introduce and study a class ofbetweenness algebras—Boolean algebras with binary operators, closely related to ternary frames with a betweenness relation. From various axioms for betweenness, we chose those that are most common, which makes our work applicable to a wide range of betweenness structures studied in the literature. On the algebraic side, we work with two operators ofpossibilityand ofsufficiency.
ENSURING CONSUMERS “GET WHAT THEY WANT”: THE ROLE OF TRADEMARK LAW
Authors: Dinwoodie Graeme B.
Published: February 2024

This Article considers how trademark law should interpret the commitment in legislative history to the 1946 (US) Lanham Act that one of the principal purposes of trademark law is “to protect the public so that it may be confident that, in purchasing a product bearing a particular trademark which it favorably knows, it will get the product which it asks for and which it wants to get”. It looks back to highlight the often under-appreciated role of the consumer protection rationale in recent expansions in trademark protection, and then considers the different ways by which that basic objective might now be pursued by trademark law. It concludes that, without disregarding the core consumer protection purpose of trademark law, we need to start viewing the question of ensuring consumers get what they want both with a broader view of consumer interests and more explicit attention to a wider array of values.
Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota
Authors: Rodriguez-Mateos Ana , Le Sayec Melanie , Cheok Alex
Published: February 2024

(Poly)phenols are plant secondary metabolites widely abundant in plant foods and beverages comprising a very large number of compounds with diverse structure and biological activities. Accumulating evidence indicates that these compounds exert beneficial effects against cardiometabolic diseases, and this review will provide a summary of current knowledge in this area. Epidemiological and clinical data collectively suggest that intake of flavonoids reduces the risk of cardiovascular disease (CVD), with the evidence being particularly strong for the flavan-3-ol subclass. However, to provide adequate dietary recommendations, a better understanding of their estimated content in foods and intake among the general public is needed. Regarding mechanisms of action, we now know that it is unlikely that (poly)phenols act as direct antioxidants in vivo, as it was hypothesised for decades with the popularity of in vitro antioxidant capacity assays. One of the reasons is that upon ingestion, (poly)phenols are extensively metabolised into a wide array of circulating metabolites with different bioactivities than their precursors. Well-conducted in vitro and in vivo studies and human nutrigenomic analysis have revealed new molecular targets that may be underlying the health benefits of (poly)phenols, such as the nitric oxide pathway. Recently, a bi-directional relationship was established between (poly)phenols and the gut microbiota, suggesting that individual gut microbial metabolising capacity may be a key factor explaining the variability in the cardiometabolic response to (poly)phenols. Future research is needed to elucidate which are the key factors affecting such capacity, and whether it can be modulated, along with the mechanisms of action.
When and how to use confirmatory composite analysis (CCA) in second language research
Authors: Alamer Abdullah , Schuberth Florian , Henseler Jörg
Published: February 2024

Researchers in second language (L2) and education domain use different statistical methods to assess their constructs of interest. Many L2 constructs emerge from elements/parts, i.e., the elements define and form the construct and not the other way around. These constructs are referred to as emergent variables (also called components, formative constructs, and composite constructs). Because emergent variables are composed of elements/parts, they should be assessed through confirmatory composite analysis (CCA). Elements of emergent variables represent unique facets of the construct. Thus, such constructs cannot be properly assessed by confirmatory factor analysis (CFA) because CFA and its underlying common factor model regard these elements to be similar and interchangeable. Conversely, the elements of an emergent variable uniquely define and form the construct, i.e., they are not similar or interchangeable. Thus, CCA is the preferred approach to empirically validate emergent variables such as language skills L2 students’ behavioral engagement and language learning strategies. CCA is based on the composite model, which captures the characteristics of emergent variables more accurately. Aside from the difference in the underlying model, CCA consists of the same steps as CFA, i.e., model specification, model identification, model estimation, and model assessment. In this paper, we explain these steps. and present an illustrative example using publicly available data. In doing so, we show how CCA can be conducted using graphical software packages such as Amos, and we provide the code necessary to conduct CCA in the R package lavaan.
A Foretaste of Heaven: Musical Teleology in Mozart's Ave verum corpus, k618
Authors: Suurpää Lauri
Published: February 2024

In June 1791, having composed almost no church music for ten years, Mozart wrote the short motet Ave verum corpus, k618, a setting of the Latin medieval eucharist hymn. The theological teleology in the text introduces a process-like aiming at a goal that cannot, however, be reached. This study is about how teleology operates in the motet – the ways in which the text's ultimately unfulfilled goal-directed processes operate in Mozart's music. The music is approached from a variety of analytical perspectives that reflect different aspects of this theme: the new Formenlehre and phrase structure, topic theory, and the analysis of voice-leading structure, register and hypermetre. Together, these approaches elucidate the multiplicity of musical processes that, as in the motet's text, announce a goal but fail to reach it.
C. P. E. Bach, Haydn and the Evolving Keyboard Idioms of the Later Eighteenth Century
Authors: Schulenberg David
Published: February 2024

The long careers of Carl Philipp Emanuel Bach and Joseph Haydn coincided with fundamental transformations in how keyboard instruments were built and played and how composers wrote for them. Haydn's keyboard music probably saw the more profound changes in compositional style, yet C. P. E. Bach and others preceded him in discovering ways to incorporate new keyboard idioms into pieces written for new types of instruments. Bach gradually shifted from writing generic keyboard music to composing in idioms most appropriate to two-manual harpsichords, unfretted clavichords or fortepianos. Haydn likewise began writing in a generic idiom; many works that have been posited as having been meant for the clavichord cannot in fact be assigned clearly to that or any other specific instrument. Although Haydn did eventually turn to writing specifically for the fortepiano, he too made a gradual, and relatively late, transition from a generic approach to one that centred on the grand fortepianos of the late eighteenth century. Bach's influence on Haydn is inseparable from the matter of the keyboard instruments. Although the precise nature and extent of Bach's influence cannot be determined, compositional elements derived by Haydn from Bach's music range from superficial thematic and notational parallelisms to fundamental conceptions of what keyboard music could be or could express.
Anomalous Cepheids: Updated Theoretical Period–Luminosity–Color and Period–Wesenheit Relations
Authors: De Somma Giulia , Marconi Marcella , Cassisi Santi , Molinaro Roberto
Published: February 2024

In the context of a project aimed to provide an updated theoretical scenario for various classes of radially pulsating stars, we present the first results obtained for anomalous Cepheids. By adopting reliable and updated evolutionary prescriptions concerning the luminosity levels for various core He-burning stellar models with masses suitable for entering the instability strip, we have computed nonlinear convective pulsation models for both fundamental and first-overtone mode anomalous Cepheids by exploring the impact of varying the metal abundance as well as the efficiency of super-adiabatic convection. These numerical simulations have allowed us to retrieve the boundaries of the instability strip and all relevant pulsation properties, namely period, amplitude, bolometric light and radial velocity curves. This theoretical scenario has been transformed into the Gaia photometric system to derive the first theoretical Period–Luminosity–Colour and Period–Wesenheit relations in the Gaia bands.
Long-Period Variables as distance and age indicators in the era of Gaia and LSST
Authors: Trabucchi Michele
Published: February 2024

Long-period variables are bright, evolved red giant stars showing periodic photometric changes due to stellar pulsation. They follow one or more period-luminosity and period-age relations, which make them highly promising distance indicators and tracers of young and intermediate-age stellar populations. Such a potential is especially interesting in view of the massive amount of data delivered by modern large-scale variability surveys. Crucially, these applications require a clear theoretical understanding of pulsation physics in connection with stellar evolution. Here, I describe an ongoing effort from our collaboration dedicated to the modelling of stellar pulsation in evolved stars, and how this work is impacting our capability of investigating long-period variables and exploiting them for other astrophysical studies. Furthermore, I present our ongoing work aimed at assessing the potential of semi-regular variables, an often neglected sub-type of long-period variables, to be distance indicators complementary to their better-known, more evolved counterparts, the Mira variables.
Period–Luminosity–Metallicity relations for Classical Pulsators at Near-infrared Wavelengths
Authors: Bhardwaj Anupam
Published: February 2024

Classical pulsating stars such as Cepheid and RR Lyrae variables exhibit well-defined Period–Luminosity relations at near-infrared wavelengths. Despite their extensive use as stellar standard candles, the effects of metallicity on Period–Luminosity relations for these pulsating variables, and in turn, on possible biases in distance determinations, are not well understood. We present ongoing efforts in determining accurate and precise metallicity coefficients of Period–Luminosity-Metallicity relations for classical pulsators at near-infrared wavelengths. For Cepheids, it is crucial to obtain a homogeneous sample of photometric light curves and high-resolution spectra for a wide range of metallicities to empirically determine metallicity coefficient and reconcile differences with the predictions of the theoretical models. For RR Lyrae variables, using their host globular clusters covering a wide range of metallicities, we determined the most precise metallicity coefficient at near-infrared wavelengths, which is in excellent agreement with the predictions of the horizontal branch evolution and stellar pulsation models.
Primary Period–Luminosity-Relation Calibrators in the Milky Way: Cepheids and RR Lyrae Physical basis, Calibration, and Applications
Authors: Groenewegen M. A. T.
Published: February 2024

In this invited review I discuss the calibration and applications of the period–luminosity relation of classical Cepheid and RR Lyrae stars. After a brief introduction, starting with results from Hipparcos and discussing some post-Hipparcos era developments, I focus on recent results using Gaia Data Release 3 data. I present an overview of the most recent period–luminosity relations, a discussion and some new results on Cepheids in open clusters. I also discuss the effect of reddening and that the use of Wesenheit indices is actually an oversimplification to dealing with the problem of reddening.
China Space Station Telescope and Variable Star Studies
Authors: Chen Xiaodian , Wang Shu , Deng Licai , de Grijs Richard , Zhou Xiaoyue , Chen Xiaohan , Zhang Jianxing
Published: February 2024

In the last five years, the number of periodic variable stars has increased by two million. We used the ZTF DR2 data to find and build a catalog that includes 780,000 periodic variable stars. These periodic variable stars were classified into 11 types, which greatly complemented the variable stars in Galactic disk. Based on the latest ZTF DR16 data, we found 2 million variable candidates. We trained a machine learner to classify variable stars, and the learner had a prediction accuracy of 94%. Using millions of variable stars, we carried out studies to optimize the period–luminosity relations and the Galactic structure and the extinction law. With the future China Space Station Telescope, millions of variable stars in the Local Group will be discovered. They help to study the structure of our Local Group and also to cross-check the distance ladders based on different variable stars.
Granulation in Red Supergiants: The Scaling Relations
Authors: Ren Yi , Zhang Zehao , Jiang Biwei , Soszyński Igor , Jayasinghe Tharindu
Published: February 2024

The evolution of granulation is an important mechanism of the light variations of red supergiants (RSGs). Based on pure and complete samples of RSGs in the Magellanic Clouds, the mechanisms and characteristics of the granulation of RSGs are investigated based on time-series data. As predicted by the basic physical process of granulation and previous works, there are tight relations between granulation and stellar parameters of RSGs (i.e., the scaling relations). The scaling relations of RSGs provide a new method to infer stellar parameters by using the characteristic timescale and amplitude of granulations. Some faint sources deviate from the scaling relations, which may be due to the difference in the properties of the granulation of the RSGs before and after the blue loop or contamination by Mira variables. However, both of these possibilities suggest that the scaling relations of granulation is different among different types of stars.
The PL diagram for δ Sct stars: back in business as distance estimators
Authors: Garca Hernández Antonio , Pascual-Granado Javier , Lares-Martiz Mariel , Mirouh Giovanni M. , Suárez Juan Carlos , Barceló Forteza Sebastiá , Moya Andrés
Published: February 2024

In this work, we focus on the period-luminosity relation (PLR) of δ Sct stars, in which mode excitation and selection mechanisms are still poorly constrained, and whose structure and oscillations are affected by rotation. We review the PLRs in the recent literature, and add a new inference from a large sample of δ Sct. We highlight the difficulty in identifying the fundamental mode and show that rotation-induced surface effects can impact the measured luminosities, explaining the broadening of the PLR. We derive a tight relation between the low-order large separation and the fundamental radial mode frequency (F0) that holds for rotating stars, thus paving the way towards mode identification. We show that the PLRs we obtain for different samples are compatible with each other and with the recent literature, and with most observed δ Sct stars when taking rotation effects into account. We also find that the highest-amplitude peak in the frequency spectrum corresponds to the fundamental modein most δ Sct, thus shedding some light on their elusive mode selection mechanism.
Sub-percent binary star masses and distances from interferometric observations
Authors: Gallenne Alexandre
Published: February 2024

Our knowledge of stellar evolution relies on constraints provided by measurements of the physical stellar properties such as the mass, effective temperature, and radii. The most fundamental parameter, the stellar mass, is rarely available or has a low accuracy, providing poor constraints on the stellar structure and evolution. Observing binary stars combining astrometry and spectroscopy offers the unique opportunity to measure very precise masses. In addition, double-lined spectroscopic binaries provide independent distance measurements with an extreme accuracy, allowing to test the Gaia parallaxes and the period-luminosity (P-L) relations. I will show that masses and distances with an accuracy level as high as 0.05% can be obtained by combining interferometric and spectroscopic observations for different types of binary systems, i.e. binary Cepheids, eclipsing and non-eclipsing binaries.
Pulsation of chemically peculiar stars
Authors: Paunzen Ernst
Published: February 2024

This paper reviews our current knowledge about pulsating chemically peculiar (CP) stars. CP stars are slowly rotating upper main-sequence objects, efficiently employing diffusion in their atmospheres. They can be divided into magnetic and non-magnetic objects. Magnetic activity significantly influence their pulsational characteristics. Only a handful of magnetic, classical pulsating objects are now known. The only exceptions are about 70 rapidly oscillating Ap stars, which seem to be located within a very tight astrophysical parameter space. Still, many observational and theoretical efforts are needed to understand all important physical aspects and their interrelationships. The most important steps to reach these goals are reviewed.
A multiphase study of classical Cepheids in the Magellanic Clouds- Models and Observations
Authors: Kurbah Kerdaris , Kanbur Shashi M. , Deb Sukanta , Das Susmita , Deka Mami , Bhardwaj Anupam , Randal Hugh Riley , Kalici Selim
Published: February 2024

This work presents the study of multiphase relations of classical Cepheids in the Magellanic Clouds for short periods (log P < 1) and long periods (log P > 1). From the analysis, it has been found that the multiphase relations obtained using the models as well as observations are highly dynamic with pulsational phase. The multiphase relations for short and long periods are found to display contrasting behaviour for both LMC and SMC. It has been observed that the multiphase relations obtained using the models agree better with the observations in the PC plane in most phases in comparison to the PL plane. Multiphase relations obtained using the models display a clear distinction among different convection sets in most phases. Comparison of models and observations in the multiphase plane is one way to test the models with the observations and to constrain the theory of stellar pulsation.
Cepheids with giant companions: A new, abundant source of Cepheid astrophysics
Authors: Pilecki Bogumił
Published: February 2024

We present a progress report of our project aiming to increase the number of known Cepheids in double-lined binary (SB2) systems from six to 100 or more. This will allow us, among other goals, to accurately measure masses for a large sample of Cepheids. Currently, only six accurate Cepheid masses are available, which hinders our understanding of their physical properties and renders the Cepheid mass–luminosity relation poorly constrained. At the same time, Cepheids are widely used for essential measurements (e.g., extragalactic distances, the Hubble constant). To examine Cepheid period–luminosity relations, we selected as binary candidates Cepheids that are too bright for their periods. To date, we have confirmed 56 SB2 systems, including the detection of significant orbital motions of the components for 32. We identified systems with orbital periods up to five times shorter than the shortest reported period to date, as well as systems with mass ratios significantly different from unity (suggesting past merger events). Both features are essential to understand how multiplicity affects the formation and destruction of Cepheid progenitors and what effect this has on global Cepheid properties. We also present eight new systems composed of two Cepheids (only one such system was known before). Among confirmed SB2 Cepheids, there are also several wide-orbit systems. In the future, these may facilitate independent accurate geometric distance measurements to the Large and Small Magellanic Clouds.
Nonlinear Rydberg exciton-polaritons in Cu2O microcavities
Authors: Makhonin Maxim , Delphan Anthonin , Song Kok Wee , Walker Paul , Isoniemi Tommi , Claronino Peter , Orfanakis Konstantinos , Rajendran Sai Kiran , Ohadi Hamid , Heckötter Julian , Assmann Marc , Bayer Manfred , Tartakovskii Alexander , Skolnick Maurice , Kyriienko Oleksandr , Krizhanovskii Dmitry
Published: February 2024

Rydberg excitons (analogues of Rydberg atoms in condensed matter systems) are highly excited bound electron-hole states with large Bohr radii. The interaction between them as well as exciton coupling to light may lead to strong optical nonlinearity, with applications in sensing and quantum information processing. Here, we achieve strong effective photon–photon interactions (Kerr-like optical nonlinearity) via the Rydberg blockade phenomenon and the hybridisation of excitons and photons forming polaritons in a Cu2O-filled microresonator. Under pulsed resonant excitation polariton resonance frequencies are renormalised due to the reduction of the photon-exciton coupling with increasing exciton density. Theoretical analysis shows that the Rydberg blockade plays a major role in the experimentally observed scaling of the polariton nonlinearity coefficient as ∝ n4.4±1.8 for principal quantum numbers up to n = 7. Such high principal quantum numbers studied in a polariton system for the first time are essential for realisation of high Rydberg optical nonlinearities, which paves the way towards quantum optical applications and fundamental studies of strongly correlated photonic (polaritonic) states in a solid state system.
Network-based drug repurposing for schizophrenia
Authors: Truong Trang T. T. , Liu Zoe S. J. , Panizzutti Bruna , Kim Jee Hyun , Dean Olivia M. , Berk Michael , Walder Ken
Published: February 2024

Despite recent progress, the challenges in drug discovery for schizophrenia persist. However, computational drug repurposing has gained popularity as it leverages the wealth of expanding biomedical databases. Network analyses provide a comprehensive understanding of transcription factor (TF) regulatory effects through gene regulatory networks, which capture the interactions between TFs and target genes by integrating various lines of evidence. Using the PANDA algorithm, we examined the topological variances in TF-gene regulatory networks between individuals with schizophrenia and healthy controls. This algorithm incorporates binding motifs, protein interactions, and gene co-expression data. To identify these differences, we subtracted the edge weights of the healthy control network from those of the schizophrenia network. The resulting differential network was then analysed using the CLUEreg tool in the GRAND database. This tool employs differential network signatures to identify drugs that potentially target the gene signature associated with the disease. Our analysis utilised a large RNA-seq dataset comprising 532 post-mortem brain samples from the CommonMind project. We constructed co-expression gene regulatory networks for both schizophrenia cases and healthy control subjects, incorporating 15,831 genes and 413 overlapping TFs. Through drug repurposing, we identified 18 promising candidates for repurposing as potential treatments for schizophrenia. The analysis of TF-gene regulatory networks revealed that the TFs in schizophrenia predominantly regulate pathways associated with energy metabolism, immune response, cell adhesion, and thyroid hormone signalling. These pathways represent significant targets for therapeutic intervention. The identified drug repurposing candidates likely act through TF-targeted pathways. These promising candidates, particularly those with preclinical evidence such as rimonabant and kaempferol, warrant further investigation into their potential mechanisms of action and efficacy in alleviating the symptoms of schizophrenia.