bluuebunny/crossref_metadata_2025 huggingface dataset:
Tungstate Sulfuric Acid (TSA)/ KMnO4 as a Novel Heterogeneous System for Rapid Deoximation
Authors: Karami Bahador , Montazerozohori Morteza
Published: October 2008

Neat chlorosulfonic acid reacts with anhydrous sodium tungstate to givetungstate sulfuric acid (TSA), a new dibasic inorganic solid acid in which two sulfuricacid molecules connect to a tungstate moiety via a covalent bond. A variety of oximeswere oxidized to their parent carbonyl compounds under mild conditions with excellentyields in short times by a heterogeneous wet TSA/KMnO4 in dichloromethane system.
Synthesis of New N-Quaternary-3-benzamidoquinuclidinium Salts
Authors: Odzak Renata , Tomic Srdjanka
Published: October 2008

The synthesis of racemic and enantiomerically pure N-p-methylbenzyl-3- and N-p-chlorobenzylbenzamidoquinuclidinium bromides (6-8 and 9-11, respectively) is described. These compounds were prepared from racemic or enantiomerically pure 3-benzamidoquinuclidines 3-5 using the appropriate quaternization reagents: p-methyl- benzyl bromide (1) and p-chlorobenzyl bromide (2).
Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions
Authors: Angeles-Beltrán Deyanira , Lomas-Romero Leticia , Lara-Corona Victor H. , González-Zamora Eduardo , Negrón-Silva Guillermo
Published: October 2008

The catalytic ability of ZrO2/SO42- to promote solventless three-componentcondensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethylacetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multi-component reactions are obtained in the presence of solid acid catalysts using the samereactants but different temperature conditions. The sulfated zirconia catalyst can berecovered and recycled in subsequent reactions with a gradual decrease of activity.
A Simple Synthesis of 2-Thiohydantoins
Authors: Wang Zerong Daniel , Sheikh Samia O. , Zhang Yulu
Published: October 2008

2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an α-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.
A Simple and Cost Effective Synthesis of 3,11-Dimethylnonacosan-2-one, A Female Sex Pheromone of the German Cockroach
Authors: Ahn Kwang–Chan , Jung Jae–Chul , Park Oee–Sook
Published: October 2008

A convenient synthesis of 3,11-dimethylnonacosan-2-one (1) is described. Our strategy involves the use of well known C–alkylation and ethyl acetoacetate synthesis reactions as key steps. We expect that this method will prove to be useful for large scale preparation of 1 and modification of dimethylnonacosanones.
Synthesis and Natural Distribution of Anti-inflammatory Alkamides from Echinacea
Authors: Kraus George A. , Bae Jaehoon , Wu Lankun , Wurtele Eve
Published: October 2008

The synthesis of the alkamides 2Z,4E-undeca-2,4-dien-8,10-diynoic acid isobutyl amide (1) and 2Z,4E-undeca-2,4-dien-8,10-diynoic acid isobutyl amide (5) was accomplished by organometallic coupling followed by introduction of the doubly unsaturated amide moiety. The distribution of these two amides in accessions of the nine species of Echinacea was determined.
Synthesis of New Unsymmetrical 4,5-Dihydroxy-2-imidazolidinones. Dynamic NMR Spectroscopic Study of the Prototropic Tautomerism in 1-(2-Benzimidazolyl)-3-phenyl-4,5-dihydroxy-2-imidazolidinone
Authors: Ghandi Mehdi , Olyaei Abolfazl , Salimi Farshid
Published: October 2008

The acid-catalyzed cyclocondensation in refluxing acetonitrile of aqueousglyoxal with N-heteroaryl-N'-phenylureas 4a-f (heteroaryl = 2-thiazolyl, 2-pyrimidinyl,2-pyrazinyl, 2-pyridinyl, 3-pyridinyl and 2-benzimidazolyl) led to the formation of thecorresponding 1-heteroaryl-3-phenyl-4,5-dihydroxy-2-imidazolidinones 5a-f. All theproducts were characterized by elemental and spectroscopic analyses. The free-energybarrier (∆GP≠ for prototropic tautomerism in 1-(2-benzimidazolyl)-3-phenyl-4,5-dihydroxy-2-imidazolidinone (5f) was determined by dynamic NMR studies to be 81 ± 2KJ molP-1
Synthesis and Properties of Novel Unsymmetrical Donor Molecules Containing p-Acetoxy- or p-Hydroxyphenyl Units
Authors: Kaboub Lakhemici , Fradj Slimane , Gouasmia Abdelkrim
Published: October 2008

We report the synthesis and properties of eight new tetrathiafulvalene (TTF) derivatives containing two different functionalities, prepared with the aim of obtaining stable organic materials. The four acetoxyphenyl- and four hydroxyphenyl TTFs were synthesized via Wittig-type condensations. The electrochemical properties of these redox-active molecules were studied by cyclic voltammetry. Charge transfer complexes with tetracyanoquinodimethane (TCNQ) were prepared by chemical redox reactions. The complexes have been proven to give conducting materials. The UV-VIS and IR spectra of the TCNQ salts were recorded and used to characterize and estimate the degree of charge transfer of these complexes.
Pongaflavanol: a Prenylated Flavonoid from Pongamia pinnata with a Modified Ring A
Authors: Yin Hao , Zhang Si , Wu Jun , Nan Haihan , Long Lijuan , Yang Jin , Li Qingxin
Published: October 2008

A new prenylated flavon-4-ol with a modified ring A, which we have named pongaflavanol (1), was isolated from the stem bark of Pongamia pinnata along with the known compound tunicatachalcone (2). The structure of compound 1 was elucidated on the basis of spectroscopic data.
Synthetic Studies Towards the ent-Labdane Diterpenoids: Rearrangement of ent-Halimanes
Authors: Marcos Isidro S. , Sexmero María J. , Hernández Felix A. , Corrales Marta , Basabe Pilar , Díez David , Urones Julio G.
Published: October 2008

For the first time ent-labdanes have been synthetised starting from ent-halimic acid, following a route that is the reverse of the biosynthetic one leading to the former compounds.
New Caulerpenyne-derived Metabolites of an Elysia Sacoglossan from the South Indian Coast
Authors: Ciavatta M. Letizia , Lopez Gresa M. Pilar , Gavagnin Margherita , Manzo Emiliano , Mollo Ernesto , D’Souza Lisette , Cimino Guido
Published: October 2008

Chemical analysis of the secondary metabolite pattern of the sacoglossan mollusc Elysia cf. expansa, collected along South Indian coasts, showed the presence of the typical Caulerpa-derived sesquiterpene caulerpenyne (1) and two new minor co- occurring metabolites, the compounds dihydrocaulerpenyne (4) and expansinol (5). The chemical characterization of these molecules, structurally related to 1, is reported
Highly Volatile Constituents of Vetiveria zizanioides Roots Grown under Different Cultivation Conditions
Authors: Pripdeevech Patcharee , Wongpornchai Sugunya , Promsiri Ampan
Published: October 2008

Roots of Vetiveria zizanioides Nash (Mae Hae; Thai ecotype) planted in three different cultivation systems (normal soil, normal soil with added microbes and semi- hydroponically) were extracted using a simultaneous steam distillation and solvent extraction (SDE) apparatus. Yields of the essential oils obtained were 0.27, 0.18 and 0.06%, respectively. The separation profiles obtained by comprehensive two-dimensional gas chromatography (GC×GC) and solid phase microextraction (SPME)-GC×GC analyses of the crude essential oils showed a total of 156 and 48 well-resolved components, respectively. The highly volatile fractions isolated from the three essential oils by SPME were subjected to analysis by GC-MS and 42 compounds were identified in total. Volatile component profiles of the oils obtained by normal soil and semi-hydroponic cultivation were similar, whereas a quantitative difference was noted in some major volatiles when the cultivation system containing microbes was utilized.
Regioselective Synthesis of Novel N2- and N4-Substituted 7-Methylpyrazolo[4,5-e][1,2,4]thiadiazines
Authors: Liu Xinyong , Yan Renzhang , Chen Niangen , Xu Wenfang , Molina Maria Teresa , Vega Salvador
Published: October 2008

The new compound 7-methylpyrazolo[4,5-e][1,2,4]thiadiazin-3(2H,4H)-one1,1-dioxide (5) was synthesized and its novel mono N2- or N4-substituted derivatives 6and 7 were prepared by regioselective N-alkylation of 5 with different molar ratios ofNaH and alkyl halides. Based on the regioselective alkylation conditions found a facileone-pot synthesis of N2,N4-disubstituted pyrazolo[4,5-e][1,2,4] thiadiazines 8 wasdeveloped. The structures of the newly synthesized compounds were confirmed by IR,1H-NMR, 13C-NMR and MS spectral analysis.
Hydantoin Derivatives of L- and D-amino acids: Synthesis and Evaluation of Their Antiviral and Antitumoral Activity
Authors: Rajic Zrinka , Zorc Branka , Raic-Malic Silvana , Ester Katja , Kralj Marijeta , Pavelic Krešimir , Balzarini Jan , De Clercq Erik , Mintas Mladen
Published: October 2008

3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h wereprepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L-and D-amino acid amides 4a-h. Compounds 5a-h were evaluated for their cytostatic andantiviral activities. Among all the compounds evaluated, 3-benzhydryl-5-isopropylhydantoin (5a) showed a weak but selective inhibitory effect against vaccinia virus (EC50 =16 μg/mL; selectivity index: 25). 3-Cyclohexyl-5-phenyl hydantoin (5g) showed inhibitoryactivity against cervical carcinoma (HeLa, IC50 = 5.4 μM) and breast carcinoma (MCF-7,IC50 = 2 μM), but also cytotoxic effects towards human normal fibroblasts (WI 38). On thecontrary, the 3-benzhydryl-5-phenyl substituted hydantoin derivative 5h showed moderateinhibitory activity towards HeLa, MCF-7, pancreatic carcinoma (MiaPaCa-2), lungcarcinoma (H 460) and colon carcinoma (SW 620) (IC50 = 20−23 μM), but no effect on WI38.
Synthesis and Biological Evaluation of New 4β-5-Fu-substituted 4'-Demethylepipodophyllotoxin Derivatives
Authors: Zhang Fu-Min , Yao Xiao-Jun , Tian Xuan , Tu Yong-Qiang
Published: October 2008

A series of new 4β-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were synthesized and evaluated, together with some previously prepared ones, for their cytotoxic activities against four tumor cell lines (HL60, P388, A549 and BEL7402). Three of these compounds exhibited superior in vitro anticancer activity against P388 and A549 than the reference compound etoposide. In addition, the partition coefficients (P) of all the new and previously synthesized derivatives were determined.
Revisiting the Reaction Between Diaminomaleonitrile and Aromatic Aldehydes: a Green Chemistry Approach
Authors: Rivera Augusto , Ríos-Motta Jaime Ríos-Motta , León Francisco
Published: October 2008

The reaction between diaminomaleonitrile (DAMN) and aldehydes and the resulting monoimines are well known. Since the standard reaction conditions involve the use of toxic solvents (typically methanol), we have sought to apply green chemistry principles to this reaction by either using water as the solvent without any catalysts or employing “solvent-free” conditions. The monoimines derived from DAMN are of interest as precursors for obtaining different heterocyclic systems and linear polymers. The methodologies used have significant advantages with regards to cost and environmental considerations.
Synthesis and Structural Characterization of 1- and 2-Substituted Indazoles: Ester and Carboxylic Acid Derivatives
Authors: Teixeira Fátima C. , Ramos Hélène , Antunes Inês  F. , Curto M. João M. , Duarte M.  Teresa , Bento Isabel
Published: October 2008

A series of indazoles substituted at the N-1 and N-2 positions with ester-containing side chains -(CH2)nCO2R of different lengths (n = 0-6, 9, 10) are described.Nucleophilic substitution reactions on halo esters (X(CH2)nCO2R) by 1H-indazole inalkaline solution lead to mixtures of N-1 and N-2 isomers, in which the N-1 isomerpredominates. Basic hydrolysis of the ester derivatives allowed the synthesis of thecorresponding indazole carboxylic acids. All compounds were fully characterised bymultinuclear NMR and IR spectroscopies, MS spectrometry and elemental analysis; theNMR spectroscopic data were used for structural assignment of the N-1 and N-2 isomers.The molecular structure of indazol-2-yl-acetic acid (5b) was determined by X-raydiffraction, which shows a supramolecular architecture involving O2-H...N1intermolecular hydrogen bonds.
Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives
Authors: Elkholy Yehya Mahmud , Morsy Mohamed Abdelhamed
Published: October 2008

2–Amino–4-phenyl–5,6,7,8–tetrahydroquinoline–3–carbonitrile (3) was synthesized by treating cyclohexanone (1) with 2–benzylidenemalononitrile (2) in the presence of ammonium acetate. The reactivity of compound 3 towards dimethylformamide dimethyl acetal (DMF-DMA), carbon disulfide, urea, thiourea, formamide, formic acid, acetyl chloride and isothiocyanate were studied. In addition, the antimicrobial activity of some selected derivatives is reported.
Copper(II) Complexes with Ligands Derived from 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one: Synthesis and Biological Activity
Authors: Rosu Tudor , Pasculescu Simona , Lazar Veronica , Chifiriuc Carmen , Cernat Raluca
Published: October 2008

The synthesis of Cu(II) complexes derived from Schiff base ligands obtainedby the condensation of 2-hydroxybenzaldehyde or terephtalic aldehyde with 4-amino-antipyrine (4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) is presented. The newlyprepared compounds were characterized by 1H-NMR, UV-VIS, IR and ESRspectroscopy. The determination of the antimicrobial activity of the ligands and of thecomplexes was carried out on samples of Escherichia coli, Klebsiella pneumoniae,Acinetobacter boumanii, Pseudomonas aeruginosa, Staphylococcus aureus and Candidasp. The qualitative and quantitative antimicrobial activity test results proved that all theprepared complexes are very active, especially against samples of Ps. aeruginosa, A.Boumanii, E. coli and S. aureus.
Improving the Quality of Published Chemical Names with Nomenclature Software
Authors: Eller Gernot  A.
Published: October 2008

This work deals with the use of organic systematic nomenclature in scientific literature, its quality, and computerized methods for its improvement. Criteria for classification of systematic names in terms of quality/correctness are discussed and applied to a sample set of several hundred names extracted from the literature. The same structures are named with three popular state-of-the-art nomenclature programs – AutoNom 2000, ChemDraw 10.0, and ACD/Name 9.0. When comparing the results, all nomenclature tools show a significantly better performance than 'average chemists'. One program allows the generation not only of IUPAC names but also of CAS-like index names that are compared with the officially registered names. The scope and limitations of nomenclature software are discussed and a comparison of the programs' actual capabilities is given.
Reactivity of 4-tert-Butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with Hydrazines
Authors: Figueroa Javier , Caballero Esther , Puebla Pilar , Tomé Fernando , Medarde Manuel
Published: October 2008

The reactivity of 6-(nitrophenyl or trimethoxyphenyl)-4-tert-butyldimethyl- siloxy-1,2,3,6-tetrahydropyridine derivatives with hydrazines under acid conditions is described. The structure of the products isolated − hydrazones, pyrazolines or pyridazinones − depended on the conditions used. In addition, a systematic study of the reaction outcomes was carried out by introducing variations on the substituents of the tetrahydropyridine ring.
Synthesis and Characterization of Dimethacrylate Monomer with High Molecular Weight for Root Canal Filling Materials
Authors: Liu Fang , He Jing-wie , Lin Zheng-mei , Ling Jun-qi , Jia De-min
Published: October 2008

A new dimethacrylate monomer 9,9'-bis[4-(2'-hydroxy-3'-methacryloyloxy-propoxy)phenyl] fluorene (3) with a molecular weight of 634 was synthesized in 51.4%yield by addition of a glycidyl ether group to 9,9'-bis(4-hydroxyphenyl) fluorene (1) bythe reaction of compound 1 with epichlorohydrin, and then introducing the methacrylatemoiety by the reaction of the epoxy group with methacrylic acid. The structure ofmonomer 3 was confirmed by FT-IR, 1H-NMR, mass spectra and elemental analysis.
Synthesis of (R)-2-(Benzyloxy)-tetrahydro-5,5-dimethylfuran by a New Oxidative Rearrangement
Authors: Díez D. , Nuñez M. G. , Moro R. F. , Garrido N. M. , Marcos I. S. , Basabe P. , Urones J.  G.
Published: October 2008

The rearrangement under oxidative conditions of 3-(benzyloxy)-tetrahydro- 2,6,6-trimethyl-2H-pyran-2-carbaldehydes to afford a chiral protected tetrahydrofuran lactol is described.
Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid
Authors: Sechi Mario , Casu Fabio , Campesi Ilaria , Fiori Stefano , Mariani Alberto
Published: October 2008

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds.
CuCl2-catalyzed One-pot Formation of Tetrahydroquinolines from N-Methyl-N-alkylanilines and Vinyl Ethers in the Presence of t-Butylhydroperoxide
Authors: Yang Xianghua , Xi Chanjuan , Jiang Yanfeng
Published: October 2008

Tetrahydroquinoline skeletons can be formed by a CuCl2-catalyzed one-potreaction of N-methyl-N-alkylanilines and vinyl ethers in the presence of t-butyl-hydroperoxide.
Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution
Authors: Zhang Li , Qiu Beiying , Li Xin , Wang Xin , Li Jingya , Zhang Yongliang , Liu Jian , Li Jia , Shen Jingkang
Published: October 2008

A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay.
Synthesis and Spectral Investigations of Manganese(II), Cobalt(II), Nickel(II), Copper(II) and Zinc(II) Complexes of New Polydentate Ligands Containing a 1,8-Naphthyridine Moiety
Authors: Swamy Sreedasyam Jagannatha , Reddy Erra Ram , Raju Devunuri  Naga , Jyothi Sunkari
Published: October 2008

2-(o-Hydroxyphenyl)-1,8-naphthyridine (HN), 2-(4-hydroxy-6-methylpyran-2-one-3-yl)-1,8-naphthyridine (HMPN) and 2-(benzimidazol-2-yl)-1,8-naphthyridine(BN) react with acetates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) to yield metal ioncomplexes of definite composition. These compounds were characterized by elementalanalyses, molar conductivity, magnetic susceptibility measurements, thermal studies, IR,UV-visible, NMR and mass spectral investigations. The complexes are found to have theformulae [M(HN)2(H2O)2], [M(HMPN)2(H2O)2] and [M(BN)2(OAc)2], respectively.
A New Neolignan Glycoside from the Leaves of Acer truncatum
Authors: Dong Lang-Ping , Ni Wei , Dong Jin-Yang , Li Jun-Zhu , Chen Chang-Xiang , Liu Hai-Yang
Published: October 2008

A new neolignan glycoside, (7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl- 8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1′-benzofuranpropanol 9′-O-β-D- glucopyranoside (1) was isolated from the leaves of Acer truncatum along with (7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl-8-hydroxymethyl-7-(4-O-α-L-rhamno- pyranosyloxy-3-methoxyphenyl)-1′-benzofuranpropanol (2), schizandriside (3), lyoniresinol (4), berchemol (5), (-)-pinoresinol-4-O-β-D-glucopyranoside (6), hecogenin (7), chlorogenic acid (8) and neochlorogenic acid (9). Their structures were elucidated on the basis of extensive spectroscopic data. The absolute configuration of compounds 1 was established by its CD spectrum. The antibacterial activities of compounds 1-7 were evaluated.
Salicylanilide Acetates: Synthesis and Antibacterial Evaluation
Authors: Vinsova Jarmila , Imramovsky Ales , Buchta Vladimir , Ceckova Martina , Dolezal Martin , Staud Frantisek , Jampilek Josef , Kaustova Jarmila
Published: October 2008

A new series of salicylanilide acetates was synthesized and evaluated for their in vitro antifungal and antituberculotic activity. Some of the evaluated compounds possessed comparable or better antifungal activity than a fluconazole standard. All these compounds exhibited very good potential and their in vitro activity against drug resistant and sensitive clinical isolates of Mycobacteria were found to be equivalent or better than a standard of isoniazide, a well-known first-line drug for tuberculosis treatment.
Synthesis, Characterization, and Saccharide Binding Studies of Bile Acid − Porphyrin Conjugates
Authors: Koivukorpi Juha , Sievänen Elina , Kolehmainen Erkki , Král Vladimír
Published: October 2008

Synthesis and characterization of bile acid-porphyrin conjugates (BAPs) are reported. Binding of saccharides with BAPs in aqueous methanol was studied by monitoring changes in the visible absorption spectral of the porphyrin-moieties. Although these studies clearly showed absorbance changes, suggesting quite high if non-selective binding, the mass spectral studies do not unambiguously support these results.
An Efficient Synthesis and Reactions of Novel Indol-ylpyridazinone Derivatives with Expected Biological Activity
Authors: Abubshait Samar A.
Published: October 2008

Reaction of 4-anthracen-9-yl-4-oxo-but-2-enoic acid (1) with indole gave the corresponding butanoic acid 2. Cyclocondensation of 2 with hydrazine hydrate, phenyl hydrazine, semicarbazide and thiosemicarbazide gave the pyridazinone derivatives 3a-d. Reaction of 3a with POCl3 for 30 min gave the chloropyridazine derivative 4a, which was used to prepare the corresponding carbohydrate hydrazone derivatives 5a-d. Reaction of chloropyridazine 4a with some aliphatic or aromatic amines and anthranilic acid gave 6a-f and 7, respectively. When the reaction of the pyridazinone derivative 3a with POCl3 was carried out for 3 hr an unexpected product 4b was obtained. The structure of 4b was confirmed by its reaction with hydrazine hydrate to give hydrazopyridazine derivative 9, which reacted in turn with acetyl acetone to afford 10. Reaction of 4b with methylamine gave 11, which reacted with methyl iodide to give the trimethylammonium iodide derivative 12. The pyridazinone 3a also reacted with benzene- or 4-toluenesulphonyl chloride to give 13a-b and with aliphatic or aromatic aldehydes to give 14a-g. All proposed structures were supported by IR, 1H-NMR, 13C-NMR, and MS spectroscopic data. Some of the new products showed antibacterial activity.
A New Poly-substituted Benzaldehyde from the Leaves of Lysimachia fordiana Oliv.
Authors: Huang Xin-an , Yang Ren-zhou , Deng Wen-di
Published: October 2008

A new poly-substituted benzaldehyde, 1, and a known compound quercetin (2) were isolated from the leaves of Lysimachia fordiana Oliv. The structure of compound 1, named fordianol, was determined as 2-heptyl-3,6-dihydroxy-4- methoxybenzaldehyde on the basis of spectroscopic methods. Fordianol did not inhibit the growth of SWO-38 (human brain neuroglioma), MCF-7 (human breast cancer) or HeLa (human cervical carcinoma) cell lines.
Microwave-Assisted Synthesis of Substituted Hexahydro-pyrrolo[3,2-c]quinolines
Authors: Neuschl Michal , Bogdal Darek , Potacek Milan
Published: October 2008

New compounds with the ethyl hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate skeleton were prepared by microwave-assisted intramolecular 1,3-dipolar cycloaddition reactions. The reactions were carried out under solvent-free conditions and compared with the same reaction in the presence of a solvent and a catalyst. Steric effects on the selectivity of the reaction were noted and evaluated.
A Convenient Approach to Heterocyclic Building Blocks: Synthesis of Novel Ring Systems Containing a [5,6]Pyrano[2,3-c]pyrazol-4(1H)-one Moiety
Authors: Eller Gernot , Holzer Wolfgang
Published: October 2008

Starting from commercially available educts, a straightforward synthetic route to new heterocyclic building blocks is exemplified with the one- or two-step synthesis of tri-, tetra-, or pentacyclic ring systems. Representatives of the following novel ring systems are prepared from 3-methyl-1-phenyl-2-pyrazolin-5-one and the corresponding o-halo-arenecarbonyl chloride using calcium hydroxide in refluxing 1,4-dioxane: pyrimidino[4',5':5,6]pyrano[2,3-c]pyrazol-4(1H)-one, thieno[3',2':5,6]pyrano[2,3c]pyrazol- 4-(1H)-one, thieno[3',4':5,6]pyrano[2,3-c]pyrazol-4(1H)-one, thieno[3'',2'':4',5']thieno[2',3':5,6]-pyrano[2,3-c]pyrazol-4(1H)-one, [1,3]dioxolo[5',6'][1]benzothieno[2',3':5,6]pyrano-[2,3-c]- pyrazol-4(1H)-one, pyridazino[4',3':5,6]pyrano[2,3-c]pyrazol-4(1H)-one and pyrazolo-[4'',3'':5',6']pyrido[3',4':5,6]pyrano[2,3-c]pyrazol-4(1H)-one. While the latter two ring systems are directly obtained due to a spontaneous intramolecular substitution reaction, in the other reactions uncyclised 4-aroylpyrazol-5-ols are produced, which are cyclised into the target heterocycles in a subsequent synthetic step (i.e. treatment with NaH in DMF). Detailed NMR spectroscopic investigations (1H-, 13C-, 15N-) with the obtained compounds were undertaken to unambiguously prove the new structures.
Simple and Regioselective Bromination of 5,6-Disubstituted-indan-1-ones with Br2 Under Acidic and Basic Conditions
Authors: Choi Taeyoung , Ma Eunsook
Published: October 2008

Bromination of 5,6-dimethoxyindan-1-one with Br2 in acetic acid at room temperature produced exclusively the corresponding 2,4-dibromo compound in 95% yield. Reaction of 5,6-dimethoxyindan-1-one with Br2 in the presence of KOH, K2CO3 or Cs2CO3 at ~0°C gave the monobrominated product 4-bromo-5,6-dimethoxyindan-3-one in 79%, 81% and 67% yield, respectively. 5,6-Dihydroxyindan-1-one was dibrominated on the aromatic ring affording 4,7-dibromo-5,6-dihydroxyindan-1-one both in acetic acid at room temperature and in the presence of KOH at ~0°C. 5,6-Difluoroindan-1-one and 1-indanone were α-monobrominated in acetic acid and α,α-dibrominated under KOH conditions at room temperature.
Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase
Authors: Gao Hong , Nishida Jun , Saito Shizuka , Kawabata Jun
Published: October 2008

Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxy-kaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxy-flavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA,while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor tomonophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity andwas a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, weconclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agentswith inhibitory effects in addition to their antioxidant properties.
Antioxidant Activity and Total Phenols in Different Extracts of Four Staphylea L. Species
Authors: Lacikova Lubica , Muselik Jan , Masterova Irena , Grancai Daniel
Published: October 2008

Staphylea L. is a deciduous ornamental shrub that possesses significant cytotoxic and antibacterial activity, although the chemical composition of its extracts and the identity of the structures responsible for these biological activities are not yet known. In this study we have determined the total phenolic content in chloroform and ethyl acetate extracts of four Staphylea species: Staphylea colchica Stev., S. elegans Zab., S. holocarpa Hemsl. and S. pinnata L.. The antioxidant potential (DPPH radical and peroxynitrite scavenging activity) of these extracts was also determined and a correlation between the phenolic content and antioxidant activities of the ethyl acetate extracts has been found. Ethyl acetate extracts were more active and one of them, obtained from S. colchica Stev., possessed the highest activity.
Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety
Authors: Pintilie Otilia , Profire Lenuta , Sunel Valeriu , Popa Marcel , Pui Aurel
Published: October 2008

New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively. The potential antimicrobial effects of the synthesized compounds were investigated using the Staphylococcus aureus ATCC 25923, Bacillus antracis ATCC 8705, Bacillus cereus ATCC 10987, Sarcina lutea ATCC 9341 and Escherichia coli ATCC 25922 strains. The newly synthesized compounds exhibited promising activities against Bacillus antracis and Bacillus cereus.
Synthesis of Functionalised Nucleosides for Incorporation into Nucleic Acid-Based Serine Protease Mimics
Authors: Catry Mieke A. , Madder Annemieke
Published: October 2008

The synthesis of nucleosides modified with an extra imidazole, carboxyl and hydroxyl group is described. These nucleosides can be incorporated into an oligonucleotide duplex, thus generating a novel type of serine protease mimic.
Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method
Authors: Kadoma Yoshinori , Atsumi Toshiko , Okada Norihisa , Ishihara Mariko , Yokoe Ichiro , Fujisawa Seiichiro
Published: October 2008

The radical-scavenging activities of the synthetic antioxidants 2-allyl-4-X-phenol (X=NO2, Cl, Br, OCH3, COCH3, CH3, t-(CH3)3, C6H5) and 2,4-dimethoxyphenol, and the natural antioxidants eugenol and isoeugenol, were investigated using differential scanning calorimetry (DSC) by measuring their anti-1,1-diphenyl-2-picrylhydrazyl (DPPH) radical activity and the induction period for polymerization of methyl methacrylate (MMA) initiated by thermal decomposition of 2,2'-azobisisobutyronitrile (AIBN) and benzoyl peroxide (BPO). 2-Allyl-4-methoxyphenol and 2,4-dimethoxy-phenol scavenged not only oxygen-centered radicals (PhCOO.) derived from BPO, but also carbon-centered radicals (R.) derived from the AIBN and DPPH radical much more efficiently, in comparison with eugenol and isoeugenol. 2-Allyl-4-methoxyphenol may be useful for its lower prooxidative activity.
Antibacterial Activity of Long-Chain Fatty Alcohols against Staphylococcus aureus
Authors: Togashi Naoko , Shiraishi Akiko , Nishizaka Miki , Matsuoka Keisuke , Endo Kazutoyo , Hamashima Hajime , Inoue Yoshihiro
Published: October 2008

The antibacterial activity against Staphylococcus aureus of long-chain fatty alcohols was investigated, with a focus on normal alcohols. The antibacterial activity varied with the length of the aliphatic carbon chain and not with the water/octanol partition coefficient. 1-Nonanol, 1-decanol and 1-undecanol had bactericidal activity and membrane-damaging activity. 1-Dodecanol and 1-tridecanol had the highest antibacterial activity among the long-chain fatty alcohols tested, but had no membrane-damaging activity. Consequently, it appears that not only the antibacterial activity but also the mode of action of long-chain fatty alcohols might be determined by the length of the aliphatic carbon chain.
Comparative Chemical Analysis of the Essential Oil Constituents in the Bark, Heartwood and Fruits of Cryptocarya massoy (Oken) Kosterm. (Lauraceae) from Papua New Guinea
Authors: Rali Topul , Wossa Stewart W. , Leach David N.
Published: October 2008

Exhaustive hydro-distillation of the bark, heartwood and fruits of Cryptocarya massoy (Lauraceae) afforded pale yellow-coloured oils in 0.7, 1.2 and 1.0 % yields, respectively. Detailed chemical evaluation of these distillates using GC/MS revealed the major components in the bark and the heartwood oils to be the C-10 (5,6-dihydro-6-pentyl-2H-pyran-2-one) and C-12 (5,6-dihydro-6-heptyl-2H-pyran-2-one) massoia lactones, while the major fruit oil constituent was benzyl benzoate (68.3 %). The heartwood also contained trace amounts of the C-14 (5,6-dihydro-6-nonyl-2H-pyran-2-one) massoia lactone (1.4 %) and the saturated C-10 derivative d-decalactone (2.5 %).
Isatinones A and B, New Antifungal Oxindole Alkaloids from Isatis costata
Authors: Fatima Itrat , Ahmad Ijaz , Anis Itrat , Malik Abdul , Afza Nighat
Published: October 2008

Two new oxindole alkaloids isatinone A (1) and B (2) have been isolated from Isatis costata, along with the known trisindoline. Their structures have been assigned on the basis of spectroscopic techniques and chemical studies. Both new compounds showed significant antifungal activity.
One Pot Synthesis of α-Aminophosphonates Containing Bromo and 3,4,5-Trimethoxybenzyl Groups under Solvent-free Conditions
Authors: Li Caihong , Song Baoan , Yan Kai , Xu Gangfang , Hu Deyu , Yang Song , Jin Linhong , Xue Wei , Lu Ping
Published: October 2008

New α-aminophosphonates were synthesized by the Kabachnik-Fields reactionof 3,4,5-trimethoxybenzaldehyde (TMB) with p- or m-bromoaniline and a dialkylphosphite under solvent-free conditions. TMB was prepared from gallic acid via a fourstep synthetic sequence involving etherification, esterification, hydrazidation andpotassium ferricyanide oxidation. The structures of all synthesized compounds wereconfirmed by elemental analysis, IR, 1H-, 13C- and 31P-NMR spectral data. Compound 7gwas also characterized by X-ray crystallography. A half-leaf method was used todetermine the in vivo curative efficacy of the eight title products against tobacco mosaicvirus (TMV). It was found that compounds 7g and 7h possess good in vivo curativeeffects against TMV.
Synthesis, NMR and Crystallographic Studies of 2-Substituted Dihydroquinazolinones Derived from (S)-Phenylethylamine
Authors: Escalante Jaime , Ortíz-Nava Claudia , Flores Patricia , Priego Jaime M. , García-Martínez Cirilo
Published: October 2008

2,3-Dihydro-3-[(S)-1-phenethyl]quinazolinone and some new 2-substitutedderivatives bearing isopropyl, o-nitrophenyl and p-nitrophenyl groups were prepared in40-90% yield by amidation of isatoic anhydride with (S)-phenylethylamine, followed bycondensation with triethyl orthoformate, isopropylaldehyde, o-nitro- and p-nitro-benzaldehyde, respectively. The two 2-subtituted dihydroquinazolinones obtained eitherby using isopropylaldehyde, o-nitro- or p-nitrobenzaldehyde, were separated and purifiedbefore their NMR spectra in CDCl3 solutions were recorded. The detection of the lowenergy conformation of O=C-N-phenethyl segment in solution allowed the correlation ofthe NMR data with the configuration of newly stereogenic carbon C-2; thus, onediastereomer was labeled SS while the other was RS. Configurations determined by theNMR method were corroborated by X-ray diffraction analysis. X-ray structures of eachdiastereomeric series showed characteristic conformational types: a propeller-like for theSS and a hairpin for the RS series. Interatomic distances of the hairpin conformationsuggest the existence of intramolecular face-to-face interactions between two aromaticrings.
Synthesis of 3,4,7,8-Tetrahydronaphthalene-1,5(2H,6H)-dione
Authors: Minne Garrett B. , De Clercq Pierre J.
Published: October 2008

A short and high yielding route for thepreparation of the title compound, starting from commercially available1,5-dihydroxynaphthalene, is described. The key step in the sequence is the airoxidation of a bis(trimethylsilyloxy)diene precursor.
Synthesis and Photochemistry of 1-Iodocyclohexene:Influence of Ultrasound on Ionic vs. Radical Behaviour
Authors: Blaskovicova Marika , Gaplovsky Anton , Blasko Jaroslav
Published: October 2008

Simultaneous application of UV light and ultrasonic irradiation to a reaction mixture containing 1-iodocyclohexene is reported. The irradiation of 1-iodocyclohexene in methanol was carried out with or without addition of zinc. The effect of ultrasound or mechanical stirring on this solid-liquid system was also compared. The irradiation of 1-iodocyclohexene in methanol in the presence of zinc increases the yield of the nucleophilic trapping product, compared with the yield after irradiation in the absence of zinc. The photodegradation of 1-iodocyclohexene was slightly accelerated after addition of zinc. A rapid formation of radical product was accompanied by substantial decrease of 1-iodocyclohexene after application of ultrasound and irradiation without the zinc. The ultrasound significantly affects the photobehaviour of this reaction, predominantly its radical route. The joint application of ultrasound and zinc contributes positively to the production of radical and ionic products. The sonochemical stirring is more effective than mechanical stirring.
Synthesis of 2,5-Disubstituted Octahydroquinolin-4-ones via anIntramolecular Hetero Diels-Alder Reaction
Authors: Ruiz Juan M. , Afonso Maria M. , Palenzuela J. Antonio
Published: October 2008

A route for the preparation of 2,5-disubstituted octahydroquinolin-4-ones, synthetic precursors of the decahydroquinoline-type toxins, is presented. The key steps are an asymmetric epoxidation and an intramolecular hetero Diels-Alder reaction between an activated diene and an imine. The presence of an allylic stereogenic center induces some selectivity and thus only two cycloadducts are obtained in 70:30 ratio and good yield.
A Novel Antioxidant Phenyl Disaccharide from Populus tremula Knotwood
Authors: Neacsu Madalina , Micol Vicente , Pérez-Fons Laura , Willför Stefan , Holmbom Bjarne , Mallavia Ricardo
Published: October 2008

The complete characterization of two compounds obtained from the acetoneextract of Populus tremula knotwood has been was achieved using LC-DAD-MS,MS/MS, IR and NMR. The new compounds were unequivocally identified as a mixtureof the ester isomers of the (E) and (Z) p-coumarate of 1-O-rutinose. The isomers showedthe capacity to inhibit lipid peroxidation induced by tert-butylhydroperoxide and to trapperoxyl radicals, as determined by a chemiluminescence method. These new phenyldisaccharides also showed a significant ORAC (oxygen radical absorbance capacity)value, i.e. 11.7 μM TE (Trolox Equivalents).
Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase
Authors: Khunnawutmanotham Nisachon , Chimnoi Nitirat , Saparpakorn Patchareenart , Pungpo Pornpan , Louisirirotchanakul Suda , Hannongbua Supa , Techasakul Supanna
Published: October 2008

Based on the molecular modeling analysis against Y181CHIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactamnitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficientroute. Some of them were evaluated for their antiviral activity against HIV-1RT subtype E and were found to exhibit virustatic activity comparable to some clinically usedtherapeutic agents.
Efficient Preparation of Aldoximes from Arylaldehydes, Ethylenediamine and Oxone® in Water
Authors: Xia Jing-Jing , Wang Guan-Wu
Published: October 2008

The one-pot reaction of aromatic aldehydes, ethylenediamine and Oxone® (2KHSO5·KHSO4·K2SO4) in pure water was found to unexpectedly afford aldoximes in excellent yields.
Asymmetric Synthesis of the Epimeric (3S)-3-((E)-Hex-1-enyl)-2-methylcyclohexanones
Authors: Vrielynck Freek A. , De Clercq Pierre J.
Published: October 2008

The asymmetric rhodium-catalysed 1,4-addition of alkenylzirconium reagents to 2-cyclohexenone can be useful in the synthesis of 3-alkenyl-2-methylcyclohexanones, provided that formaldehyde is used in trapping the intermediate zirconium enolates. In this manner a four-step sequence leading to the two epimeric 3-hexenyl-2-methylcyclohexanones in enantiomeric form was developed.
Synthesis, Characterization and AntibacterialActivity of Azomethine Derivatives Derived from 2-Formylphenoxyacetic Acid
Authors: Iqbal Amjid , Siddiqui Hamid Latif , Ashraf C. M. , Ahmad Matloob , Weaver George W.
Published: October 2008

A series of eight new azomethine derivatives were synthesized by reacting 2-formylphenoxyacetic acid with aromatic amines. The chemical structures of these compounds were confirmed by means of 1H-NMR, 13C-NMR, MS and elemental analysis. The compounds were assayed by the disc diffusion method for antibacterial against Staphylococcus aureus and Escherichia coli. Among the compounds tested, 2a, 2b, 2e, 2g and 2h exhibited good antibacterial activity, almost equal to that of Ciprofloxacin used as standard.
Heteropolyacids as Green and Reusable Catalysts for the Synthesis of 3,1,5-Benzoxadiazepines
Authors: Heravi Majid M. , Sadjadi Samaheh , Oskooie Hossein A. , Shoar Rahim Hekmat , Bamoharram Fatemeh F.
Published: October 2008

Synthesis of 3,1,5-benzoxadiazepines from the condensation of o-phenylenediamine (o-PDA) and acyl chlorides in the presence of a catalytic amount of various heteropolyacids (HPAs) is reported.
Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana
Authors: Fiorentino Antonio , D'Abrosca Brigida , Pacifico Severina , Golino Annunziata , Mastellone Claudio , Oriano Palma , Monaco Pietro
Published: October 2008

One new and six known flavone glycosides were isolated from the MeOH extract of Melilotus neapolitana Ten. The new compound, identified as 7-O-β-D-gluco-pyranosyloxy-4',5-dihydroxy-3-[O-α-L-rhamnopyranosyl-(1→6)-3-O-β-D-glucopyrano-syloxy]flavone (1) by 1D and 2D NMR techniques and mass spectra, was isolated along with kaempferol-3-O-rutinoside (2), kaempferol-3-O-glucoside (3), rutin (4), quercetin-3-O-glucoside (5), isorhamnetin-3-O-rutinoside (6), and isorhamnetin-3-O-glucoside (7). The antioxidant and radical scavenging activities of these compounds and the whole crude methanol extract were evaluated. The organic extract can inhibit MDA marker’s synthesis by 57%. All the metabolites displayed good reducing power, with the kaempferol (2,3) and isorhamnetin derivatives (6,7) being less active than the corresponding quercetin derivatives 4,5.
Synthesis and Biological Evaluation of Rigid Polycyclic Derivatives of the Diels-Alder Adduct Tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione
Authors: Ito Felicia Megumi , Petroni Jacqueline Marques , De Lima Dênis Pires , Beatriz Adilson , Marques Maria Rita , De Moraes Manoel Odorico , Costa-Lotufo Letícia Veras , Montenegro Raquel Carvalho , Ferreira Magalhãe Hemerson Iury , Do Ó Pessoa Cláudia
Published: October 2008

art of our research program concentrates on the discovery of new bioactivecompounds prepared either by total synthesis or molecular transformation of compoundswith bioactivity profiles. In this work we have focused our interest on chemicaltransformations of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione inorder to obtain cage-like compounds and derivatives, followed by an evaluation of theirbiological activity.
Comparison of ChemicalComposition and Free Radical Scavenging Ability of Glycosidically Bound andFree Volatiles from Bosnian Pine (Pinus heldreichii Christ. var. leucodermis)
Authors: Maric Stanislava , Jukic Mila , Katalinic Visnja , Milos Mladen
Published: October 2008

The results obtained show that Bosnian pine is richin glycosidically bound volatile compounds with strong free radical scavengingproperties. Since volatiles can be released from nonvolatile glycosideprecursors, these compounds can be considered as a hidden potential source ofantioxidant substances and may contribute to the total free radical scavengingability of Bosnian pine.
Modelingof Acetylene Pyrolysis under Steel Vacuum Carburizing Conditions in a Tubular Flow Reactor
Authors: Khan Rafi Ullah , Bajohr Siegfried , Graf Frank , Reimert Rainer
Published: October 2008

In the present work, the pyrolysis of acetylene was studied under steel vacuumcarburizing conditions in a tubular flow reactor. The pyrolysis temperature ranged from650 °C to 1050 °C. The partial pressure of acetylene in the feed mixture was 10 and 20mbar, respectively, while the rest of the mixture consisted of nitrogen. The total pressureof the mixture was 1.6 bar. A kinetic mechanism which consists of seven species andnine reactions has been used in the commercial computational fluid dynamics (CFD)software Fluent. The species transport and reaction model of Fluent was used in thesimulations. A comparison of simulated and experimental results is presented in thispaper.
Syntheses and Biological Activities of 6-Aryl-3-(3-hydroxy- propyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines
Authors: Jin Jian-yu , Zhang Li-xue , Chen Xian-xing , Zhang An-jiang , Zhang Hai-le
Published: October 2008

A series of 6-aryl-3-(3-hydroxypropyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]-thia-diazines were synthesized by the reaction of 4-amino-3-(3-hydroxypropyl)-5-mercapto-1,2,4-triazole (1) with substituted ω-haloacetophenones. Their structures were confirmed by elemental analysis, IR, 1H-NMR, and 13C-NMR. Tests of plant growth regulating effects showed that the title compounds display remarkable inhibitory activities on the growth of radish and wheat.
Effective Oxidation of Sulfides to Sulfoxides with Hydrogen Peroxide under Transition-Metal-Free Conditions
Authors: Golchoubian Hamid , Hosseinpoor Farideh
Published: October 2008

A “green” highly selective oxidation of organic sulfides to the corresponding sulfoxides was developed using hydrogen peroxide and glacial acetic acid under transition metal-free and mild conditions. The oxidation procedure is very simple and the products are easily isolated in excellent yields (90-99%).
Mistletonone, a Novel Antioxidative Diarylheptanoid from the Branches and Leaves of Viscum coloratum
Authors: Yao Hui , Zhou Guang-Xiong , Wu Qiong , Lei Guang-Qing , Chen Dao-Feng , Chen Jia-Kuan , Zhou Tong-Shui
Published: October 2008

Mistletonone, a novel diarylheptanoid, was isolated from the branches and leaves of Viscum coloratum (Kom.) Nakai (Loranthaceae). It was identified as 1,7-di-(p-hydroxyphenyl)-5-hydroxyl-cis-2,3-epoxy-1-one on the basis of spectral evidence. The compound showed significant scavenging effects on hydroxyl radicals and superoxide anion radicals in the direct assay using the electron spin resonance (ESR) technique.
Oxidative Degradations of the Side Chain of Unsaturated Ent-labdanes. Part I.
Authors: Catalán Luis Espinoza , Altamirano Héctor Carrasco , Fritis Mauricio Cuellar , Araya Claudio Gallardo , Marín Karen Catalán
Published: October 2008

A selective route for the degradation of the unsaturated side chain of ent-labdanes has been devised, giving two useful synthons: 2β-acetoxy-14,15,17-trinor-ent-labdane-8,13- dione (5) and 2β-acetoxy-14,15-dinor-ent-labd-8(17)-en-13-one (7), the use of which for the preparation of terpenylquinone derivatives shall be reported elsewhere.
Acylated Flavone Glycosides from the Roots of Saussurea lappa and Their Antifungal Activity
Authors: Rao Kolisetty Sambasiva , Babu Goriparthi Venu , Ramnareddy Yemireddy Venkata
Published: October 2008

The isolation of four novel acylated flavonoid glycosides from the roots of Saussurea lappa and their identification using a combination of 1D and 2D NMR and mass spectrometry is described. The in vitro antifungal and antibacterial activities of the isolated compounds and their mixture were tested on nine fungal and four bacterial strains, using the microdilution method. The compounds and mixture showed moderate to high antifungal activity against most of the fungi tested, compared to a miconazole standard, while only one compound and the mixture showed antibacterial activity against all strains tested.
Synthesis of New 1,3-Disubstituted-2,3-dihydro-1H-naphth[1,2e][1,3]oxazines
Authors: Turgut Zuhal , Pelit Emel , Köycü Adem
Published: October 2008

1,3-Disubstituted-2,3-dihydro-1H-naphth[1,2-e][1,3]oxazines were prepared through the ring-closurereactions of the aminobenzylnaphthols with substituted aryl-andheteroarylaldehydes.
New Diterpenoid Alkaloids from the Roots of Delphinium tiantaishanense
Authors: Li Jie , Chen Dong-Lin , Jian Xi-Xian , Wang Feng-Peng
Published: October 2008

Four new diterpenoid alkaloids: tiantaishansine (1), tiantaishannine (2), tiantaishanmine (3), and tiantaishandine (4) have been isolated from the roots of Delphinium tiantaishan. Their structures were elucidated by chemical evidence andspectral analyses, including ESI-MS, HR-EI-MS, 1D- and 2D-NMR.