bluuebunny/crossref_metadata_2025 huggingface dataset:
An efficient hybrid model of CNNs and different kernels of SVM for brain tumor classification
Authors: Bourennane Mohammed , Naimi Hilal
Published: November 2023

Technological advancements have had a profound impact on various aspects of human existence. The realm of medicine is one major area where technology has made important advances. We will talk specifically about the role technology has had in treating brain tumors, a serious and widespread condition. A large number of people pass away from brain tumors every year. Patients with BTs have a worse likelihood of survival when they receive subpar care and a false diagnosis. The most widely employed technique for detecting brain tumors is magnetic resonance imaging (MRI). Moreover, MRI is extensively utilized in medical imaging and image processing to identify variations in various regions of the body. A convolutional neural network (CNN)-based model was developed in this study to classify brain tumor. Using nine pre-trained CNN models (efficientnetb0, mobilenetv2, nasnetlarge, resnet50, resnet10, googlenet, vgg16, vgg19, and shufflenet), deep features were extracted from the acquired images. Then use a Support Vector Machines (SVM) classifier to classify the deep features. The classification accuracy results obtained from the various kernel functions, namely linear, gaussian, cubic, and quadratic—was then compared. The deep features retrieved from the efficientnetb0 model allowed accurate classification of brain tumors. The classification accuracy achieved using the Gaussian kernel function of SVM was recorded at an impressive 99.78%.
Refleksje o przemijaniu i o pamięci przeszłości. Staropolski dialog z tradycją antyczną (na podstawie „Nowych Aten” ks. Benedykta Chmielowskiego)
Authors: Wichowa Maria
Published: November 2023

Przedmiotem badań jest refleksja o przemijaniu, naturze czasu i o pamięci przeszłości starożytnej w Nowych Atenach B. Chmielowskiego jako element tradycji antycznej kultywowany w pierwszej polskiej encyklopedii. Autor dzieła podkreślał ciągłość i wysoką rangę tradycji, obserwował proces twórczego rozwoju tych wartości, które nam przekazała przeszłość. Uważał, że jesteśmy naśladowcami i inwentorami, doskonalącymi dobra kultury wytworzone przez antyk. Chmielowski zamieścił w tomie III swego dzieła dyskurs na temat: Który wiek, stary czy nowy polerowniejszy? i wykazał wyższość starożytności. Uważał, że czerpiemy pełnymi garściami z tradycji antycznej, doceniamy wielkość dokonań starożytnych intelektualistów i twórców, nie przerośliśmy ich pod żadnym względem, przetwarzamy tylko to co oni nam przekazali jako dziedzictwo. Encyklopedysta był przekonany, że współczesna mu kultura całkowicie oparła się na tradycji antycznej.
Ночной посетитель, или о том, как Пушкин спародировал Шекспира
Authors: Szczukin Wasilij
Published: November 2023

Задача автора статьи заключалась в том, чтобы осуществить интертекстуальный «палимпсестный» анализ поэмы Александра Пушкина Граф Нулин с целью выявления происхождения основных мотивов этого произведения. Последние восходят к Истории Рима со дня его основания Тита Ливия, а также к поэме Шекспира Лукреция (1594). Анализ показывает, что Пушкин создал пародию шекспировской поэмы, существенным образом изменив экзистенциальную трактовку образов Лукреции и Тарквиния.
Древнерусская “Повесть о бражнике” в интерпретации старообрядческих полемистов
Authors: Пигин Александр
Published: November 2023

Повесть о бражнике – памятник древнерусской «смеховой» литературы, в основе которого лежит западноевропейский «бродячий» сюжет о грешнике, сумевшем доказать, что у него не меньше прав находиться в раю, чем у апостолов и библейских царей. В 1860-е гг. повесть обратила на себя внимание старообрядцев-поповцевбелокриницкого согласия в ходе полемики со старообрядцами-беспоповцами. Она была включена в число десяти эсхатологических и этиологических легенд, в которых поповцы усмотрели саму суть опровергаемого ими беспоповского учения об антихристе. Разбор этих сочинений был предпринят писателями белокриницкого согласия И. Г. Кабановым в 1862 г. и М. И. Бриллиантовым в 1903 г. В статье показано, как в интерпретации старообрядческих полемистов произошла перекодировка смысла литературного сочинения. Комическая новелла была прочитана в соответствии с совершенно иными идеологическими и эстетическими установками как кощунственный еретический текст.
Z rozważań nad tekstem donżuanowskim literatury rosyjskiej
Authors: Szymańska Aleksandra
Published: November 2023

W artykule rozważana jest możliwość ustanowienia na gruncie literaturoznawstwa rosyjskiego, poprzez analogię do tekstu petersburskiego, tekstu donżuanowskiego literatury rosyjskiej. W tym celu ustanowiony został zespół cech wspólnych dla utworów odwołujących się do postaci Don Juana. Jednym z dowodów istnienia tekstu donżuanowskiego jest krąg tekstów odwołujących się do modelu słynnego uwodziciela i prześmiewcy. Innymi wyznacznikami są obecność osnowy mitycznej, związek ze sferą sacrum i profanum, obecność konstant w zachowaniu Don Juana, zbliżony sposób językowego kodowania i inne.
Determination of Lethal Dose 50 for Induced Mutagenesis in Soybean [Glycine max (L.) Merril] cv. Gepak Kuning Through Ethyl Methane Sulfonate Mutagen
Authors: . Nilahayati , Handayani Rd. Selvy , . Nazimah , Harahap Muhammad Sani Alfikri , Irawan Gusti , . Rosmaina
Published: November 2023

Background: The improvement of the genetic and agronomic properties of cultivated plants can be carried out by various plant breeding methods, including mutation breeding. Mutations in nature are very few and rare. Ethyl Methane Sulfonate (EMS) is a chemical mutagen that can cause random mutations resulting in changes in genetic material. This study aims to determine the effect of EMS on the germination of soybean (cv. Gepak Kuning) seeds. Methods: The research was conducted at the Faculty of Agriculture Laboratory, Universitas Malikussaleh, Indonesia, in January 2023. The concentrations of EMS used were 0%, 0.025%, 0.05%, 0.1%, 0.25%, 0.5% and 1% with a soaking time of 4 hours. EMS concentration of 0% was used as a control treatment. The observed variables were made as percentage of germination (%) and seedling height at 7th day and 14th day after planting. Result: The results showed that an increase in EMS concentration affected the percentage of germination of soybean (cv. Gepak Kuning) sprouts. A decrease in the percentage of germination was found at an EMS concentration of 0.5%, while a decrease in seedling height had begun to be seen at an EMS concentration of 0.25%. The results of the analysis with CurveExpert 1.4 software showed that the LD50 value of the seeds of soybean (cv. Gepak Kuning) treated with EMS mutagen was at a concentration of 0.63%, the LD20 dan LD30 value was at a concentration of 0.25% and 0.41%, respectively.
Outcomes of a Breast Pump Combining Compression and Vacuum Technology in Exclusively Pumping Mothers of VLBW Infants in the NICU
Authors: Wight Nancy , Turfker Kelley , Spencer Becky , Grassley Jane
Published: November 2023

Objective:To determine whether exclusively pumping mothers of very low birth weight (VLBW) neonatal intensive care unit (NICU) infants could achieve adequate milk production using the PJ’s Comfort®multiuser breast pump, with its compression and vacuum technology and flexible silicone breast cup.

Methods:We employed a single-site, convenience sample, 24-month, prospective, nonexperimental, descriptive study in NICU mothers of VLBW infants who were asked to complete a pumping log for 15 days.

Results:Of mothers with complete pumping logs (36/51), the mean time to first pumping was 9.5 hours and the mean number of pumping sessions was 7.4/24 hours. By day 15, 83% reached a milk volume of ≥350 mL/day, 66% reached ≥500 mL/day, and 29% reached ≥700 mL/day. Comments regarding the comfort, ease of use, and features of the pump were very favorable.

Conclusions:Using current technologies, PJ’s Comfort®is a cost-effective option for establishing adequate milk production in mothers of VLBW infants in the NICU.
A cardboard revolution? The women’s strikes placards and their very own lives
Authors: Sieracka Joanna
Published: November 2023

This article is an analysis of the poetics of the women’s strikes which took place in Poland in 2020 in response to the ruling of the Constitutional Tribunal that tightened Polish abortion law by banning pregnancy termination due to fetal anomalies. My main focus is on cardboard placards made by the protesters and used at the demonstrations. Comparing them with the poetics of the black protests launched in 2016 as a response to a bill restricting Polish abortion law, I take as my starting point the recognition of the revolutionary character of the recent mobilization, emphatically showcased—as shown by my analysis and the findings of other scholars (e.g., P. Czapliński and A. Graff)— in breaking with all the symbolic languages and the post-transition social contract, a gesture expressive of the rejection of the strategy of assimilation to the national-conservative hegemony. Analyzing multiple references to Adam Mickiewicz’s Dziady, magical thinking, and spell formulas in the poetics of the women’s strikes, I highlight the significance of the carnivalization of the protests. I argue that thanks to it, new languages of reproductive rights emerged, alternative sources of community were evoked, and the slogans written on cardboard placards and banners and chanted during the demonstrations and marches created a relatively autonomous universe of their own. In conclusion, I seek to answer whether cardboard placards, if performatively used, can constitute cultural change and re-represent the values for which the protesters fight.
Arte Correio entre contextos
Authors: Alves Fabíola Cristina
Published: November 2023

O presente artigo tem como objetivo traçar conexões entre a história da arte local e global a partir da coleção de Arte Correio preservada no Museu de Arte do Núcleo de Arte e Cultura da Universidade Federal do Rio Grande do Norte (NAC-UFRN). Para tanto, apresenta-se uma breve reconstrução do contexto histórico e artístico da cidade de Natal (RN), considerando o período da ditadura e da redemocratização. Em seguida, aborda-se as redes de trabalho da Arte Correio dentro do contexto regional e nacional, nas quais se destaca a participação do artista Jota Medeiros, responsável pela formação da coleção objeto deste artigo. Por fim, busca-se compreender a coleção a partir de uma análise qualitativa.
Harald Szeeman, o colecionador de obsessões
Authors: Martins Tatiana da Costa
Published: November 2023

As artes visuais e suas narrativas envolvem vários agentes. O colecionador possui destaque por congregar conjuntos materiais que permitem arranjos quase infinitos como fontes históricas, além de inscrever-se na própria fatura do discurso histórico e na visualidade contemporânea. A análise da Exposição Grandfather: a Pioneer like us, de 1974, procura compreender a dupla prática de Harald Szeeman: curatorial e colecionista. Essa perspectiva, aliada aos temas benjaminianos, abre vias para redimensionar a História da Arte.
The Maqashidiyya Dimension of Ibn Taymiyyah's Thoughts on Jihad
Authors: Pratama Yoga
Published: November 2023

This research aims to examine the Maqashidiyah dimensions (sharia goals) in Ibn Taimiyah's thoughts about jihad. Ibn Taimiyah's thoughts on jihad are analyzed in the context of Maqashid al-Shariah which includes the maintenance of the soul, the maintenance of the mind, the maintenance of religion, and the maintenance of property. The research method used is literature study by analyzing relevant works of Ibn Taimiyah, especially in relation to jihad. Research findings show that in his thinking, Ibn Taymiyah viewed jihad as a legitimate form of self-defense to protect the lives and safety of Muslims from oppression, aggression and threats of violence. Jihad also involves protecting the thoughts and beliefs of Muslims from influences that corrupt the mind, as well as the spread of Islamic teachings as part of intellectual jihad. Apart from that, Ibn Taimiyah saw jihad as an effort to defend the Islamic religion from the threat of disbelief,maintaining the continuity of religion, and fighting injustice. Protection of Muslim property was also a concern of Ibn Taymiyah in the context of jihad, with an emphasis on protecting Muslim wealth and defending their rights. This research provides a deeper understanding of the Maqashidiyah dimension in Ibn Taimiyah's thinking about jihad and contributes to the development of thinking about jihad in a broader context.
Electrospun Polyurethane Vascular Grafts for Cerebral Revascularization: A Pilot Study on Rats
Authors: Vergauwen Evelynn , Tubeeckx Michiel RL , Houben Annemie , Van Vlierberghe Sandra , Demolder Marc , De Meyer Guido RY , Pauwels Patrick , Menovsky Tomas
Published: November 2023

Background: The current standard technique for vascular grafting in cerebral revascularization surgery is through the interposition of an autologous blood vessel. Technical complications have necessitated the development of a synthetic alternative, but classical biomaterials are not suited for small caliber vascular grafting due to neointimal hyperplasia and thrombosis. Electrospinning of polymers is a promising technique for the development of small vascular grafts. The in vivo performance and efficacy of electrospun polyurethane (ePU) grafts with an internal diameter of < 1.5 mm have thus far not been evaluated.
Methods: We developed a novel ePU graft with a diameter of 1.25 mm for implantation into the infrarenal aorta of rats.
Results: Patency rates of grafts after a four-month-period were equal to those reported in other studies with larger ePU graft diameters, and equal or higher than in studies with other biomaterials. We observed some loss in flow velocity throughout the grafts, which suggests a decreased elasticity of the graft compared to native rat aorta. However, the grafts demonstrated good neo-endothelialization and minimal neointimal hyperplasia. Their porosity promoted cellular infiltration, as shown on tissue slide examination.
Conclusion: Our results show that ePU vascular grafts with internal diameter of < 1.5 mm are promising candidates for vascular grafting in cerebral revascularization surgery.
Identifying an Implementation Framework for Integrating Drones into STEM and Career Technology Education CTE Programs
Authors: Slater Timothy F
Published: November 2023

As drone technology is rapidly becoming accessible to school children in terms of both low cost and ease-of-use, primary and secondary school teachers are beginning to consider where modern drones can play an important role in schooling. To date, there is very little empirical education research printed in the education research literature guiding innovative curriculum developers in the incipient domain of drone education. As a result, teachers interested in including emerging technologies in their classrooms are often at a loss of where to begin. Through clinical interviews with schoolteachers in the United States, our study identified five readily accessible “departure points” to include drones in contemporary STEM & vocational technology (CTE) school classrooms that help teachers address common curricular goals. Taken together, these interviews reveal that teachers using drones follow one of several distinct pathways as a first step toward achieving a widespread goal of teaching students to use modern technologies to construct, pursue, and communicate findings of fruitful research inquiries—the prevalence of which is not reflected in a comprehensive literature review. The five pathways for starting a successful drone education emerging from the interview data as dominant were: timed-racing trials; precision-flight obstacle courses; computer coding; videography; and domain-specific knowledge of drone operations laws and ethics.
The Role of TLR-2 in Lethal COVID-19 Disease Involving Medullary and Resident Megakaryocites Up-Regulation in the Microthrombosis Mechanism
Authors: Pannone Giuseppe Prof , Pedicillo Maria Carmela , De Stefano Ilenia Sara , Barile Raffaele , Meccariello Mario , Agostinone Alessio , Pannone Chiara , Villani Giuliana , PIZZULLI CRISTINA , Miele Francesco , Ramunno Maria Antonietta , Municinò Maurizio , Serviddio Gaetano , Ronchi Andrea , Zito Marino Federica , Franco Renato , Colangelo Tommaso , Zamparese Rosanna
Published: November 2023

Patients with COVID-19 have coagulation and platelet disorders, with platelet’s alterations and thrombocytopenia representing negative prognostic parameters, being associated with severe forms of the disease, and increase lethality. Methods: Aim of this study was to study expression of platelet glycoprotein IIIa (CD61), playing a critical role in platelet aggregation, together with TRL-2 as a marker of innate immune activation Results: a total of 25 patients were investigated, with the majority (24/25, 96%) having co-morbidities and dying from a fatal form of SARS-CoV-2(+) infection (COVID-19 +), with 13 men and 12 females ranging in age from 45 to 80 years. When compared to a control group of SARS CoV-2 (-) negative lungs (COVID-19 -), TLR-2 expression was up-regulated in a subset of patients with deadly COVID-19 fatal lung illness. The proportion of Spike-1 (+) patients found by PCR and ISH correlates to the proportion of Spike-S1 positive cases as detected by digital pathology examination. Furthermore, CD61 expression was considerably higher in the lungs of dead patients. In conclusion, we demonstrate that innate immune prolonged hyperactivation is related to platelet/megakaryocytes over-expression in the lung. Conclusions: microthrombosis in deadly COVID-19+ lung disease is associated with an increase in the number of CD61+ platelets and megakaryocytes in the pulmonary interstitium as well as their functional activation; this phenomenon is associated with increased expression of innate immunity TLR2+ cells, which binds the SARS-CoV-2 E protein, and significantly with the persistence of the Spike-S1 viral sequence.
Exploring the Mechanism of Activation of CFTR by Curcuminoids: An Ensemble Docking Study
Authors: Bellacchio Emanuele
Published: November 2023

Curcumin, a major constituent of turmeric, has beneficial effects against several diseases. In cystic fibrosis (CF), this compound potentiates the activity of a number of cystic fibrosis transmembrane conductance regulator (CFTR) mutants. Despite holding promise in the treatment of CF, the curcumin binding site in CFTR and the molecular mechanism of activation of this channel are still unknown. The results of the study, based on docking and molecular dynamics (MD) simulations, allow to propose that curcumin binds the closed ATP-free CFTR near the NBD1/ ICl1/ICl4 interface. The bound ligand, once approached by NBD2 during transient channel opening, lays at a multiple interdomain cross point. Thereafter, curcumin can bridge NBD1 and NBD2, and also ICL1/ICL4 and ICL2/ICL3 finally tightening the same interdomain interactions that normally uphold the active conformation in the wild type ATP-bound CFTR. The proposed binding site is compatible with biochemical observations made in previous CFTR-curcumin interaction studies. These findings provide the framework for the design of novel drugs that activate CFTR mutants characterized by defects in ATP binding and/or NBD dimerization, or even lacking NBD2.
RNA-Sequencing Analysis Revealed Genes Associated Stem Rot Responses at Different Infection Stages in sweetpotato(Ipomoea Batatas (L.) Lam.)
Authors: Chen Li , Liang Zhang , Honghu Ji , Weihan Song , Ziyu Zong , Meiqiao Jiang , Yungang Zhang , Qiang Li , Linrun Cheng , Meng Kou
Published: November 2023

Sweetpotato is an important miscellaneous grain crop in China, which is threatened by a variety of diseases and insect pests in the process of cultivation and production. sweetpotato stem rot is one of the common sweetpotato diseases, which seriously affects the yield and quality of sweetpotato. However, there are few studies on the mechanism of resistance to stem rot in sweetpotato. In this study, transcriptome sequencing analysis was carried out on the samples at different stages (T1, T2, T3) of stem rot pathogen infecting Xushu 48, and 44839 (T1-VS-T2), 81436 (T1-VS-T2) and 61932 (T2-VS-T3) differentially expressed genes (DEGs) were obtained. The DEGs were mainly concentrated in Alanine, aspartate and glutamate metabolism (ko00250), Carbon fixation in photosynthetic organisms (ko00710) and Amino sugar and nucleotide sugar metabolism (ko00520) and some candidate genes related to plant pathogen infection, such as receptor-like protein kinase (RLK5, RLK7), LRR receptor-like serine/threonine-protein kinase (SERK1), bHLH137, ERF9, MYB73 and NAC053, were screened. The results of this study provide genetic resources for the research on stem rot resistance of sweetpotato and provide theoretical basis for sweetpotato resistance breeding.
Mid-Infrared Complex Refractive Index Spectra of Polycrystalline Copper-Nitride Films by IR-VASE Ellipsometry and Their FIB-SEM Porosity
Authors: Márquez Emilio , Blanco Eduardo , Manuel Jose Manuel , Ballester Manuel , Garcia-Gurrea Marcos , Rodriguez-Tapiador Maria Isabel , Fernandez Susana Maria , Willomitzer Florian , Katsaggelos Aggelos K.
Published: November 2023

Copper-nitride (Cu3N) semiconductor material is attracting much attention as a potential, next-generation thin-film solar-light absorber in solar cells. In this communication, polycrystalline Cu3N thin films were prepared using reactive-RF-magnetron-sputtering deposition, at room temperature, onto glass and silicon substrates. The very-broadband optical properties of the Cu3N thin film layers were studied by UV-MIR (0.2-40 μm) ellipsometry and optical transmission, to be able to achieve the goal of a low-cost absorber material to replace the conventional silicon. The reactive-RF-sputtered Cu3N films were also investigated by focused ion beam scanning electron microscopy, and both FTIR and Raman spectroscopies.
Genetic Psychophysiology and Markers of Resilience to Anxiety and Depression in Sports and Extreme Professions
Authors: Mosse Irma , Charykova Inna , Stepanova Elena , Smetanina Darya , Riabinin Aleksei , Sedlyar Nikita , Talako Tatsiana , Ljubisavljevic Milos , Statsenko Yauhen
Published: November 2023

Background: A personalized approach to occupational medicine allows specialists to 1
prevent professional hazards such as stress-related depression and anxiety in extreme work environments. Objective: we aim to detect genetic markers of low resilience to stress. Methods: The study cohort included 97 elite athletes and 167 special forces personnel. The research team collected buccal mucosa samples and examined psychological status with the Hospital Anxiety and Depression Scale (HADS). We assessed 35 variants within selected genes that are most often associated with low resilience to stress, anxiety, and depression. Fisher’s Exact test was used to determine nonrandom associations between scores in the HADS scale and the genetic variants. We also trained machine learning models to predict score values from genotyping findings and ranked genetic biomarkers according to their predictive power. Results: High-risk depression profiles included C/T genotype of MTHFR C677T and A/C variant of MTHFR A1298C. Susceptibility to anxiety was associated with several polymorphisms regulating neuroactive substances, immune response, and coagulation. The ML models accurately detect depression or anxiety levels with MAE/ROV of 17.69±1.35 and 17.86±2.09% respectively. Conclusions: The study findings justify a polymorphic nature of anxiety and confirm the immune system's involvement in regulating stress response.
Assessment Method Research of Structural Risk Reliability on Continuous Beam Bridge in Cantilever and Horizontal Rotation Constructing Based on Interval Reliability Theory
Authors: Yuan Linyu , Yang Huan , Zou Zhaoyong , Dong Fenghui
Published: November 2023

In this paper, based on the symmetrical reliability theory, a research method for the safety factor of overall overturning stability of continuous beam bridge under carbon fiber reinforced polymers (CFRP) during cantilever and horizontal rotation construction is proposed. Under the premise that the given target reliability index is known, the method solves the overall overturning stability safety factor of continuous beam bridge under carbon fiber reinforced polymers during cantilever and horizontal rotation construction by using the symmetrical reliability analysis theory and considering the randomness of structural parameters. This method is used to calculate the safety factor and the design reinforcement aera of CRFP of overturning stability and the design reinforcement aera of CRFP of a continuous beam bridge, and the parameters are analyzed. The calculation results show that the randomness of parameters will have a great impact on the overall safety factor and the CRFP aera of overturning stability of cantilever and horizontal rotation construction of continuous beam bridge, and ignoring the influence of randomness of parameters will lead to overestimation of the overall safety factor and underestimation of the CRFP aera of overturning stability of cantilever and horizontal rotation construction of continuous beam bridge.
Reasons for the increase in cyber attacks: analysis of technical and non-technical factors
Authors: Vasilyev A. A.
Published: November 2023

This article presents an analysis of both technical and non-technical factors contributing to the growth in volume and diversity of cyber attacks. Social interaction on the Internet contributes to the increased frequency of cyber attacks and exacerbates destructive consequences that extend beyond technical aspects, impacting societal and personal realms. Software errors, vulnerabilities, and deficiencies in network protocols pose a persistent security threat, particularly amidst the rising number of connected devices and the complexity of managing critical systems. The dynamic nature of attacks and evolving penetration methods make cyber threats highly adaptable to the conditions of the modern network environment.

Furthermore, the expanded use of social media and the virtualization of social life bring increased comfort but also provide fertile ground for cyber attacks, amplifying the volume of accessible information for potential malicious actors. The heightened technical proficiency of attackers equips them with new tools for breaching digital security. Concurrently, inadequate awareness and careless user behavior online jeopardize the protection of personal and confidential data.

This work demonstrates that cyber risks escalate due to both ongoing technological changes and human actions. Understanding the dynamics of these factors becomes critically important for developing more effective measures to safeguard the digital environment.
Diversidad jurídica en el tratamiento del «Crowdfunding»
Authors: De la Vega García Fernando
Published: November 2023

La crisis económica y la generalización de las nuevas tecnologías han expandido la economía colaborativa a numerosos sectores. En el ámbito financiero el crowdfunding adquiere especial protagonismo, al ampliar la posibilidad de acceso a la financiación y al crédito a personas que con anterioridad la tenían muy difícil. El artículo presenta el sistema jurídico del crowdfunding, poniendo en evidencia cómo su tratamiento por el Derecho no se corresponde con la idea de unidad que deriva de la utilización de crowdfunding como termino comprensivo de todas sus modalidades.
Defensa de la competencia, acción de daños y exenciones
Authors: Rodríguez Díaz Isabel
Published: November 2023

El Real Decreto-ley 9/2017, de 26 de mayo, por el que se transponen directivas de la Unión Europea en los ámbitos financiero, mercantil y sanitario, y sobre el desplazamien-to de trabajadores, contiene las modificaciones derivadas de la transposición de la Directiva 2014/104/UE del Parlamento Europeo y del Consejo, de 26 de noviembre de 2014 que es-tablece determinadas normas por las que se rigen, en virtud del Derecho nacional, las ac-ciones de daños resultantes de las infraccio-nes del Derecho de la competencia de los Es-tados miembros y de la Unión Europea. El ci-tado Real Decreto-ley 9/2017 modifica la Ley 15/2007, de 3 de julio, de Defensa de la Com-petencia (LDC), introduciendo un nuevo título VI relativo a la compensación de los daños causados por las prácticas restrictivas de la competencia, que abarca los artículos 71 a 81.
Las Novedosas Sociedades por Acciones Simplificadas en el Derecho Argentino: riesgos a la luz del sistema de prevención de lavado de activos
Authors: Suozzi Leonell
Published: November 2023

La consolidación de la Ley de Apoyo al Capital Emprendedor es un hito más en las intenciones de la República Argentina de fomentar el desarrollo productivo y la innovación, dejando atrás las problemáticas de los trámites burocráticos y los costos y demoras de deberes formales. Entre otros institutos, se creó un nuevo tipo societario para sumarse a los enumerados en la Ley General de Sociedades, denominado “Sociedad por Acciones Simplificada”. Este tipo implica la constitución y funcionamiento de sociedades unipersonales o pluripersonales sin mayores exigencias y en tiempo récord. Si bien demuestra ser una herramienta fundamental para los incipientes emprendedores de buena fe, manifiesta también serias dudas en lo que hace a un adecuado sistema de prevención de lavado de activos y financiamiento del terrorismo, atento a la posibilidad de crear múltiples firmas ficticias mediante las cuales desarrollar las maniobras en cuestión.
LIABILITY FOR THE DEBTS OF A DISSOLVED COMPANY. IS THE ITALIAN LEGAL SYSTEM LOSING CONTEST WITH OTHER EUROPEAN SYSTEMS?
Authors: Pasquariello Federica
Published: November 2023

Italian legal framework provides two credit protection strategies which can be employed to enforce the liability for debts ( both contingent liabilities and unpaid debit residuals ) of a dissolved company: the first based on Company Law , the other on Bankruptcy Law.According to Company Law, by virtue of art. 2495, Civil code, capital companies which have been removed from the Register after a liquidation process(1), are to be considered extinct. Moreover, according to the Court of Cassation, U.S.,February 22nd, 2010, no. 4060-4061-4062(2) the same conclusion can be drawn for partnerships because of systematic coherence. Therefore, following the cancellation from the Company Registry, the companies no longer exist neither as legal entities nor as subjects of law. Shareholder and liquidator will respond in different ways to any surviving or overdue social debt, according to artt. 2312 and 2495 c.c.
LA CONTINUIDAD Y LA REHABILITACIÓN DE LOS SERVICIOS PÚBLICOS ANTE EL CONCURSO PREVENTIVO DEL DEUDOR. SU REGULACIÓN EN EL DERECHO CONCURSAL ARGENTINO
Authors: Gerbaudo Germán E.
Published: November 2023

En este trabajo se analiza la existencia de deudas por la prestación de servicios públicos frente a la presentación en concurso preventivo del deudor. Se estudia la  regulación prevista en el art. 20 de la Ley de Concursos y Quiebras de la República Argentina.
“Breve comentario de la Propuesta de Directiva sobre marcos de reestructuración preventiva y segunda oportunidad”.
Authors: Vilas Álvarez David
Published: November 2023

Al final del proceso legislativo europeo, ya se puede realizar un balance, aunque sea preliminar, del contenido de la propuesta de Directiva sobre marcos de reestructuración preventiva y segunda oportunidad –o quizás sería mejor decir exoneración-. En el presente artículo se analizan sus disposiciones más destacadas en los distintos temas que regula, así como su eventual influencia en el proceso normativo español, con vistas a una –enésima- reforma de la normativa concursal patria.
PROBLEMÁTICA DEL CRÉDITO HIPOTECARIO EN EL CONCURSO DE ACREEDORES
Authors: Fortea Gorbe José Luis
Published: November 2023

En el artículo se examina la regulación sustantiva y la especial problemática del crédito hipotecario en el concurso de acreedores, mediante una aproximación resumida y práctica.
CONTRATOS INTELIGENTES Y EVALUACIÓN DE LA SOLVENCIA EN EL CRÉDITO INMOBILIARIO
Authors: Bárcena Suárez Nicolás
Published: November 2023

La preocupación del legislador europeo por reducir el riesgo de impago en el mercado de crédito inmobiliario ha reforzado los sistemas de evaluación de solvencia de los estados europeos. El mecanismo más habitual empleado por la banca para medir los riesgos de un contrato de préstamo o crédito es el denominado credit score. La irrupción de la tecnología blockchain y los denominados smart contracts arrojan un nuevo escenario para el ámbito del credit score pero también algunas dudas debido a la ausencia de regulación concreta.
Burden of illness among patients with asthma prescribed inhaled corticosteroids/long-acting β2-agonists
Authors: Zhang Shiyuan , Czira Alexandrosz , Harley Julia , Rothnie Kieran , Lee Lauren , Small Mark
Published: November 2023

Inhaled corticosteroids (ICS) plus long-acting β2-agonists (LABA) are recommended for maintenance-only or maintenance and reliever therapy (MART) in patients with asthma. However, real-world data on ICS/LABA as maintenance-only or MART are limited. This study characterized clinical, economic, and humanistic burdens of asthma in Canada, China, Europe, Japan, and the US, using data collected from patients and physicians via a cross-sectional survey (Asthma Disease Specific Programme). Patients were ≥18 years of age with physician-confirmed asthma and receiving fixed-dose ICS/LABA for ≥3 months. Mean physician-reported symptom-free days over the past 30 days ranged from 10.1–20.6 days, and 31.5–34.6% of ICS/LABA users self-reported not well-controlled asthma. SABA co-prescription was reported in 8.8–67.8% of patients. These findings highlight the continued disease burden among ICS/LABA users, with the high level of SABA co-prescription indicating potentially inappropriate prescribing of ICS/LABA as MART or detrimental reliance on SABA medication in addition to MART.
Manipulating Charge-to-Spin Conversion via Insertion Layer Control at the Interface of Topological Insulator and Ferromagnet
Authors: Cho Mann-ho , Kim Jonghoon , Lee Young min , Rho Seungwon , Hong Seok-Bo , Kim Dajung , Park Jaehan , Huh Jaeseok , Jeong Kwangsik
Published: November 2023

Owing to their unique electronic properties and potential for charge-to-spin conversion (CSC), topological insulators (TIs) are emerging materials for spintronic applications, particularly in spin-orbit torque magnetoresistive random-access memory. Strong spin-orbit coupling and highly spin-polarized surface states in TIs are key parameters that explain their extremely high CSC efficiency at interfaces with ferromagnetic materials (FMs). Therefore, the performance of TI-based spintronic devices is strongly influenced by the interface between the TI and FM, where various interactions and effects occur, such as atomic intermixing, charge transfer, exchange coupling, and induced magnetism. This study focused on the influence of the insertion layer on the proximity effect occurring in a Co4Fe4B2/Bi2Se3 interface. Various insertion layers, including Au, MgO, and Se, were introduced to modulate the proximity effect from TI to FM and vice versa. X-ray photoelectron spectroscopy and transmission electron microscopy revealed that the Se insertion layer effectively suppresses the formation of an additional Bi layer, reducing intermixing against Co4Fe4B2. Electrical transport properties such as RXX and RXY under a vertical magnetic field show that the Se-inserted structure features the lowest anomalous Hall angle and exhibits a pristine topological surface state, indicating its potential for improving CSC efficiency. The Se-inserted structure exhibits the highest spin Hall angle among various heterostructures, according to results obtained from spin-torque ferromagnetic resonance. These findings highlight the importance of selecting an insertion layer and controlling the interface to optimize the spin-transport properties of TI-based spintronic devices and provide insights into the design of future spin devices.
Assessment of Dynamical Downscaling Performance over CORDEX East Asia using MPAS-A Global Variable Resolution Model: Climatology, Seasonal Cycle, and Extreme Events
Authors: Cheng YiYuan , Tang Jianping , Lu Yixiong , Fang Juan
Published: November 2023

A 29-year variable resolution climate simulation is conducted from January 1988 to December 2016 using the Model for Prediction Across Scale-Atmosphere (MPAS-Atmosphere) with prescribed sea surface temperatures obtained from ERA-Interim reanalysis. The global variable resolution configuration employed a mesh refinement of 92-25km centered over East Asia (MPAS-A experiment, hereafter), which could preserve multi-scale features within the same model framework. The evaluation of MPAS-A is performed for precipitation, near-surface air temperature, and circulation features against observed climate using combined observational datasets. The MPAS-A experiment exhibited large-scale deviations due to the absence of observational constraints, especially for the northward displacement of rain belts, excessive rainfall over the tropical ocean, and stationary surface air temperature biases tied to specific regions. These deviations can be explained by the simulated circulation, moisture transports, and the relationship between precipitation and convective available potential energy (CAPE). While the simulated seasonal cycles and frequency are dominated by large-scale deviation patterns, certain climate indices demonstrated lower sensitivity in the refined regions, particularly regarding extreme rainfall. This finding underscores the robustness and potential of the variable resolution (VR) approach in obtaining regional information within a single model framework.
Metformin and Dapagliflozin Decrease Fetuin A, Hepatic & Pancreatic Fat and Hepatic Fibrosis in Asian Indians with Type 2 diabetes
Authors: Dutta Koel , Bhatt Surya Prakash , Ghosh Amrita , Gupta Ritesh , Tyagi Kanika , Ansari Irshad Ahmad , Pandey Shivam , Misra Anoop
Published: November 2023

Background and Objective: We intended to evaluate the effect of Metformin intervention for 120 days on hepatic and pancreatic fat, hepatic fibrosis, and Metformin and dapagliflozin (DAPA), fetuin A levels in patients with type 2 diabetes (T2D).
Methods: This is a prospective study. Patients (n, 15) were given 1000mg of metformin/day and DAPA for a period of 120 days. Changes in anthropometry, surrogate markers of insulin resistance, body composition, fibroscan, liver, and pancreatic fat and serum fetuin-A were evaluated. Fibrosis-4 index (FIB) for liver fibrosis and hepatic steatosis index (HSI) was calculated.
Results: After 120 days of treatment with Metformin and DAPA, a significant reduction in body weight, body mass index (BMI), %body fat, waist and hip circumferences, and total skinfold thickness was seen. A significant reduction in fetuin-A was seen with both Metformin and DAPA treatment, previously not reported for latter drug. Metformin significantly decreased CAP and kPa (fibroscan) but did not decrease hepatic and pancreatic fat (MRI-PDFF). Furthermore, FIB-4 and HIS scores were significantly decreased after 120 days of treatment with Metformin.
Conclusions: Metformin and DAPA, after 120 days of use, reduced Fetuin A levels, and Metformin decreased FIB-4, HIS score, hepatic fibrosis but not hepatic and pancreatic fat in Asian Indian patients with T2D.
Clinical Trial Number: Clinical Trials.gov: NCT05939921 (11/07/2023).
Dust traps in protoplanetary disks
efficiently form organic macromolecular matter
Authors: Ligterink Niels , Pinilla Paola , Marel Nienke van der , Scheltinga Jeroen Terwisscha van , Booth Alice , Alexander Conel , Riebe My
Published: November 2023

The chondritic building blocks from which Earth formed contain most of their elemental carbon and other volatiles in organic macromolecular matter. This substance is essential to set the chemical composition of terrestrial planets and start the emergence of life, but how it formed is unknown. We demonstrate that this organic macromolecular matter can efficiently form in dust traps – a prominent planet formation mechanism – in the solar nebula. By combining a protoplanetary disk dust evolution model with radiative transfer, we confirm that dust traps host regimes where ice-coated grains receive exceptionally large doses of radiation of several 10’s of eV molecule-1 year-1. This allows for the processing of approximately 4% of the total disk ice reservoir from simple molecules into complex macromolecular matter in a matter of decades. This finding shows that planet formation and the emergence of organic macromolecular matter that sets habitable conditions, are intimately linked.
Impact of human CD8+ T cell senescence on 89Zr radiolabelling and homing properties
Authors: Bystrom Jonas , Carrascal-Miniño Amaia , Keeling George P , Pham Truc , Garrod-Ketchley Conor , Schroth Johannes , De Rosales Rafael T. M. , Terry Samantha YA , Henson Sian M
Published: November 2023

Background
The ability of CD8+ T cells to protect against infection and malignant transformation diminishes with age. Novel means to assess cellular functional deficits in vivo are being made available such as total-body positron emission tomography (PET) and radiotracers with long half-lives. Here, we determined radiolabeled human CD8+ T cells isolated from young and old individuals with zirconium-89 (89Zr) and assessed their biological status in vitro and distribution in vivo.
Results
Fresh and cryopreserved CD8+ T cells showed no difference in ability to be labelled with 89Zr, radionuclide retention, or CD8+ T cell phenotype. 89Zr induced partial cell death and DNA damage, which was no longer detectable visible after four days. The level of DNA repair observed in old samples was highly variable. 89Zr efflux from cells, seen in vitro, did not occur in vivo. Longitudinal PET imaging indicated that CD8+ T cells from old individuals accumulated in tissues at a slower rate than those isolated from young individuals.
Conclusion
We have established a strategy to label and track the biodistribution of cryopreserved CD8+T cells. Further study is required to understand differences in migratory behaviour of CD8+ T cells isolated from old and young individuals.
Serum 25-hydroxyvitamin D and nasopharyngeal carcinoma risk and survival: a hospital-based matched prospective case-control study in Malaysia
Authors: Ulaganathan Vaidehi , Lye Munn-Sann , Al-Olayan Ebtesam , Loh Su-Peng , Yap Yoke-Yeow , Kandiah Mirnalini , Augundhooa Digsha , Gunasekaran Baskaran
Published: November 2023

Serum 25(OH) D deficiency may be one of the underlying molecular mechanisms through which chronic inflammation is associated with risk and survival of nasopharyngeal carcinoma (NPC). This study was conducted to determine the association between serum 25(OH) D and NPC risk and survival. A multi-centric case-control study was conducted from two local hospitals. A total of 300 histologically confirmed NPC cases were matched with controls for age, gender and ethnicity and assessed for vitamin D status and other factors. Mean serum 25(OH) D was significantly lower in NPC patients compared with controls (25.3 ± 7.7 ng/mL vs. 27.0 ± 9.2 ng/mL, p = 0.016). Multiple logistic regression analysis indicated that higher levels of serum 25(OH) D was associated with reduced odds of NPC (AOR = 0.73, 95% CI = 0.57–0.94) controlling for confounders including BMI, physical activity, smoking status, alcohol consumption, consumption of food high in vitamin D, salted fish consumption and family history of NPC. There was a significant association between insufficient serum 25 (OH) D status with accumulation of four risk factors and increased odds of getting NPC using fractional polynomial analysis. Increased NPC odds was observed after accumulation of second risk factors with presence insufficient serum 25 (OH) D status (OR = 0.54, 95% CI = 0.27, 4.77, OR = 1.04, 95% CI = 0.64, 1.72, OR = 1.15, 95% CI = 0.73, 1.80, OR = 1.93, 95% CI = 1.13, 3.31, and OR = 5.55, 95% CI = 1.67, 10.3 respectively). The 5-year survival rates were 51.0%, 57.0% and 43.0% for serum 25(OH) D deficiency, insufficiency and sufficient respectively. These findings highlight the potential preventive benefits of maintaining higher levels of serum 25(OH) D in mitigating NPC risk, though further research is needed to explore its impact on survival outcomes.
Skeletal muscle-specific prolyl hydroxylase-2 deficient mice release more lactate into the blood during acute exercise and have greater endurance running capacity
Authors: Kubota Takahiro , Takada Hiroaki , Osana Shion , Nunomiya Aki , Nagatomi Ryoichi
Published: November 2023

Prolyl hydroxylase domain 2 (PHD2) deficiency has been shown to activate hypoxia inducible factor (HIF), which improves the effects of endurance exercise training. In previous research, although systemic knockout of Phd2 causes an increase in blood hematocrit levels, only knockout Phd2 does not cause an increase in exercise capacity. At the time when the endurance of Phd2 knockout mice was significantly increased by post-training, an increase in slow muscle fibers in skeletal muscle and metabolic changes were observed. Thus, the contribution of hypoxic response in skeletal muscle is likely to be significant. Since the hypoxic response occurs in various organs and tissues throughout the body, a model in which the hypoxic response occurs only in skeletal muscle is needed to find the cause of the improved effects of hypoxic training in skeletal muscle. We therefore generated mice genetically modified to lack Phd2 specifically in skeletal muscle (Phd2mKO mice) and measured their endurance exercise capacity. We found that Phd2mKO mice ran 13.3% longer than control mice in an endurance running test. Furthermore, the number of contractions before the muscle contractility decayed by half was increased by 26% in the measurement of muscle endurance by forced muscle contraction of the gastrocnemius muscle by electrical stimulation. Furthermore, acute exercise increased blood lactate levels by 56% and showed differential expression of the metabolism-related genes GLUT1, GLUT4 MCT1 MCT4 in skeletal muscle. This suggests that the local hypoxic response in skeletal muscle improves endurance exercise capacity without changes in blood hematocrit levels due to altered expression of metabolism-related genes.
Optimization of nonlinear equations with constraints using genetic algorithm
Authors: Čajić phd can sc Elvir
Published: November 2023

This scientific paper investigates the effectiveness of applying the genetic algorithm in solving nonlinear equations with set constraints. A genetic algorithm is used as an optimization method to find a solution to a system of equations that satisfies a given set of constraints. The paper analyzes the performance of the genetic algorithm in the context of solving non-linear problems, providing insight into its applicability and advantages compared to other methods.