bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S11 from miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer
Authors: Orso Francesca , Quirico Lorena , Virga Federico , Penna Elisa , Dettori Daniela , Cimino Daniela , Coppo Roberto , Grassi Elena , Elia Angela Rita , Brusa Davide , Deaglio Silvia , Brizzi Maria Felice , Stadler Michael B. , Provero Paolo , Caselle Michele , Taverna Daniela
Published: March 2023

miR-148b target genes analysis
Supplementary Table 3 from Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma
Authors: De Rienzo Assunta , Archer Michael A. , Yeap Beow Y. , Dao Nhien , Sciaranghella Daniele , Sideris Antonios C. , Zheng Yifan , Holman Alexander G. , Wang Yaoyu E. , Dal Cin Paola S. , Fletcher Jonathan A. , Rubio Renee , Croft Larry , Quackenbush John , Sugarbaker Peter E. , Munir Kiara J. , Battilana Jesse R. , Gustafson Corinne E. , Chirieac Lucian R. , Ching Soo Meng , Wong James , Tay Liang Chung , Rudd Stephen , Hercus Robert , Sugarbaker David J. , Richards William G. , Bueno Raphael
Published: March 2023

Expression levels for BAP1, NF2, TP53, MYH9, MYH6, MYH10, PIK3C2A, RHOA, and TNFRSF1A detected by Affymetrix® Human Gene 1.1 ST Array in 151 MPM
Supplementary Table 2 from Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma
Authors: De Rienzo Assunta , Archer Michael A. , Yeap Beow Y. , Dao Nhien , Sciaranghella Daniele , Sideris Antonios C. , Zheng Yifan , Holman Alexander G. , Wang Yaoyu E. , Dal Cin Paola S. , Fletcher Jonathan A. , Rubio Renee , Croft Larry , Quackenbush John , Sugarbaker Peter E. , Munir Kiara J. , Battilana Jesse R. , Gustafson Corinne E. , Chirieac Lucian R. , Ching Soo Meng , Wong James , Tay Liang Chung , Rudd Stephen , Hercus Robert , Sugarbaker David J. , Richards William G. , Bueno Raphael
Published: March 2023

List of the tumor specific mutations identified by whole-genome sequencing and validated in the 10 pairs of MPM tumor and germline DNA samples
Supplementary Figure 1 from Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma
Authors: De Rienzo Assunta , Archer Michael A. , Yeap Beow Y. , Dao Nhien , Sciaranghella Daniele , Sideris Antonios C. , Zheng Yifan , Holman Alexander G. , Wang Yaoyu E. , Dal Cin Paola S. , Fletcher Jonathan A. , Rubio Renee , Croft Larry , Quackenbush John , Sugarbaker Peter E. , Munir Kiara J. , Battilana Jesse R. , Gustafson Corinne E. , Chirieac Lucian R. , Ching Soo Meng , Wong James , Tay Liang Chung , Rudd Stephen , Hercus Robert , Sugarbaker David J. , Richards William G. , Bueno Raphael
Published: March 2023

Expression levels of candidate genes in 151 patients by gender and histology
Supplementary Table S2 from Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications
Authors: Popova Tatiana , Manié Elodie , Boeva Valentina , Battistella Aude , Goundiam Oumou , Smith Nicholas K. , Mueller Christopher R. , Raynal Virginie , Mariani Odette , Sastre-Garau Xavier , Stern Marc-Henri
Published: March 2023

Structural alterations detected by mate-pair WGS in 3 in-house ovarian cancer cases
Supplementary Table 3 from A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis
Authors: Fang Liang , Zhu Qionghua , Neuenschwander Martin , Specker Edgar , Wulf-Goldenberg Annika , Weis William I. , von Kries Jens P. , Birchmeier Walter
Published: March 2023

Table S3. Gene function clustering using the DAVID bioinformatics resources. Table S1. Gene function clustering using the DAVID bioinformatics resources.
Supplementary Figure Legends from Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer
Authors: Concha-Benavente Fernando , Srivastava Raghvendra M. , Trivedi Sumita , Lei Yu , Chandran Uma , Seethala Raja R. , Freeman Gordon J. , Ferris Robert L.
Published: March 2023

Supplementary Figure Legends
Supplementary Figure S1 from SSBP1 Suppresses TGFβ-Driven Epithelial-to-Mesenchymal Transition and Metastasis in Triple-Negative Breast Cancer by Regulating Mitochondrial Retrograde Signaling
Authors: Jiang Hong-Lin , Sun He-Fen , Gao Shui-Ping , Li Liang-Dong , Huang Sheng , Hu Xin , Liu Sheng , Wu Jiong , Shao Zhi-Ming , Jin Wei
Published: March 2023

(A) Representative HE staining images of nude mouse lungs six weeks after the tail vein injection of MDA-MB-231 and MDA-MB-231Bo cells. (B) The SSBP1 peptide sequence was detected by iTRAQ labeling. (C) The fold change ratio of breast cancer cell lines (MDA-MB-231, MDA-MB-231HM and MDA-MB-231Bo) based on quantitative proteomic analysis (D) Western blotting for SSBP1 in MDA-MB-231 parent and MDA-MB-231HM, MDA-MB-231Bo subclone confirming expression levels seen in proteomic analyses. (E) Log2 expression levels for mitochondrial proteins from the MDA-MB-231 parent and MDA-MB-231-derivated cell lines.
Supplementary Figure 3 from NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis
Authors: Shoshan Einav , Braeuer Russell R. , Kamiya Takafumi , Mobley Aaron K. , Huang Li , Vasquez Mayra E. , Velazquez-Torres Guermarie , Chakravarti Nitin , Ivan Cristina , Prieto Victor , Villares Gabriel J. , Bar-Eli Menashe
Published: March 2023

Immunohistochemistry of tumor samples after silencing or overexpressing NFAT1 in melanoma cells
Supplementary Figure 1 from NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis
Authors: Shoshan Einav , Braeuer Russell R. , Kamiya Takafumi , Mobley Aaron K. , Huang Li , Vasquez Mayra E. , Velazquez-Torres Guermarie , Chakravarti Nitin , Ivan Cristina , Prieto Victor , Villares Gabriel J. , Bar-Eli Menashe
Published: March 2023

Effect of NFAT1 silencing or overexpression on melanoma cell viability
Supplementary Figure S1 from Hemolytic E. coli Promotes Colonic Tumorigenesis in Females
Authors: Jin Ye , Tang Senwei , Li Weilin , Ng Siew Chien , Chan Michael W.Y. , Sung Joseph J.Y. , Yu Jun
Published: March 2023

E. coli typing based on fimH mutation patterns of fecal E. coli isolates. (A) Cluster analysis of single-nucleotide polymorphisms (SNP) of 711 fimH sequences. At the bottom of the figure are point mutations and their positions relative to the start codon of fimH. Red color represents that the mutations occur; blue color represents that the mutations do not occur. The horizontal box indicates the mutation pattern of type1-fimH. The vertical box indicates SNPs that are specific to type1-fimH and absent from the other types of fimH. (B) Distribution of the four types of E. coli in different subject groups. Each column represents a subject; each row represents fimH types of randomly selected fecal E. coli isolates. Color scheme: purple, type 1; blue, type 2, orange, type 3, green, type 4. (C) Percentage of subjects positive with each type of E. coli in different subject groups. H, the healthy subjects serving as controls; AD, patients with adenoma; CRC, patients with colorectal cancer. ***P < 0.001.
CAN-15-1348R-Supplementary Figure-S5 from Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression
Authors: Mittapalli Venugopal R. , Madl Josef , Löffek Stefanie , Kiritsi Dimitra , Kern Johannes S. , Römer Winfried , Nyström Alexander , Bruckner-Tuderman Leena
Published: March 2023

Bar graph and immunofluorescence stainings
CAN-15-1348R-Supplementary Figure-S3 from Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression
Authors: Mittapalli Venugopal R. , Madl Josef , Löffek Stefanie , Kiritsi Dimitra , Kern Johannes S. , Römer Winfried , Nyström Alexander , Bruckner-Tuderman Leena
Published: March 2023

Images of Western blot analysis
Supplementary Table S1 from Macrophage Infiltration and Alternative Activation during Wound Healing Promote MEK1-Induced Skin Carcinogenesis
Authors: Weber Christine , Telerman Stephanie B. , Reimer Andreas S. , Sequeira Ines , Liakath-Ali Kifayathullah , Arwert Esther N. , Watt Fiona M.
Published: March 2023

List of all Taqman probes used during qPCR
Supplementary figure 1 from p73 and IGF1R Regulate Emergence of Aggressive Cancer Stem–like Features via miR-885-5p Control
Authors: Meier Claudia , Hardtstock Philip , Joost Sophie , Alla Vijay , Pützer Brigitte M.
Published: March 2023

DNp73 regulates stemness
Supplementary Methods from p73 and IGF1R Regulate Emergence of Aggressive Cancer Stem–like Features via miR-885-5p Control
Authors: Meier Claudia , Hardtstock Philip , Joost Sophie , Alla Vijay , Pützer Brigitte M.
Published: March 2023

Description of additional experimental procedures used in the study.
Supplementary Table S12 from Transcriptome Analysis of Recurrently Deregulated Genes across Multiple Cancers Identifies New Pan-Cancer Biomarkers
Authors: Kaczkowski Bogumil , Tanaka Yuji , Kawaji Hideya , Sandelin Albin , Andersson Robin , Itoh Masayoshi , Lassmann Timo , Hayashizaki Yoshihide , Carninci Piero , Forrest Alistair R.R.
Published: March 2023

Primers used for the qRTPCR validations.
Supplementary Movie 2 from Modeling Spontaneous Metastasis following Surgery: An In Vivo-In Silico Approach
Authors: Benzekry Sebastien , Tracz Amanda , Mastri Michalis , Corbelli Ryan , Barbolosi Dominique , Ebos John M.L.
Published: March 2023

Supplementary Movie 2: Primary tumor (PT) was assumed to be detected when reaching the size of 4.32 cm in diameter. Post-diagnosis PT growth and development of metastases in the case of no surgical intervention are indicated as dashed line in the left plot and white bars in the histogram on the right, respectively.
Supplementary Table S1 from Transcriptome Analysis of Recurrently Deregulated Genes across Multiple Cancers Identifies New Pan-Cancer Biomarkers
Authors: Kaczkowski Bogumil , Tanaka Yuji , Kawaji Hideya , Sandelin Albin , Andersson Robin , Itoh Masayoshi , Lassmann Timo , Hayashizaki Yoshihide , Carninci Piero , Forrest Alistair R.R.
Published: March 2023

List of all samples from FANTOM5 CAGE data.
Supplementary Figures 1 through 5 from Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells
Authors: Cheng Chun-Ting , Kuo Ching-Ying , Ouyang Ching , Li Chien-Feng , Chung Yiyin , Chan David C. , Kung Hsing-Jien , Ann David K.
Published: March 2023

Supplementary Figure S1. KAP1 transcript level is positively associated with some of mitochondrial complex genes expression in breast cancer patients. Supplementary Figure S2. KAP1 overexpression is associated with breast cancer poor prognosis. Supplementary Figure S3. p38MAPK, but not AMPK or ATM, activates metabolic stress-induced KAP1 phosphorylation at Ser473. Supplementary Figure S4. Time-dependent alterations of Mitochondrial dynamics upon glucose depletion. Supplementary Figure S5. S473A-KAP1 promotes mitochondrial network and sensitizes MDA-MB-231/shKAP1 cells to glucose starvation.
Supplementary Figure S1 from HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc
Authors: Li Yinghui , Wang Zhen , Shi Hui , Li Hang , Li Leilei , Fang Runping , Cai Xiaoli , Liu Bowen , Zhang Xiaodong , Ye Lihong
Published: March 2023

The common targets of HBXIP and c-Myc are involved in the cell cycle and ribosome biosynthesis pathways.
Supplementary Methods from Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway
Authors: Ohtsu Naoki , Nakatani Yuka , Yamashita Daisuke , Ohue Shiro , Ohnishi Takanori , Kondo Toru
Published: March 2023

Description of additional methods and procedures used in the study.
Supplementary_Scr autophagy from Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology
Authors: Dutta Samikshan , Roy Sohini , Polavaram Navatha S. , Stanton Marissa J. , Zhang Heyu , Bhola Tanvi , Hönscheid Pia , Donohue Terrence M. , Band Hamid , Batra Surinder K. , Muders Michael H. , Datta Kaustubh
Published: March 2023

Autophagy_live cell
Supplementary Fig 7 from Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology
Authors: Dutta Samikshan , Roy Sohini , Polavaram Navatha S. , Stanton Marissa J. , Zhang Heyu , Bhola Tanvi , Hönscheid Pia , Donohue Terrence M. , Band Hamid , Batra Surinder K. , Muders Michael H. , Datta Kaustubh
Published: March 2023

Depletion of NRP2 axis affect EGFR endocytosis
Supplementary Fig 2 from Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology
Authors: Dutta Samikshan , Roy Sohini , Polavaram Navatha S. , Stanton Marissa J. , Zhang Heyu , Bhola Tanvi , Hönscheid Pia , Donohue Terrence M. , Band Hamid , Batra Surinder K. , Muders Michael H. , Datta Kaustubh
Published: March 2023

Overexpression of NRP2 or knockdown of WDFY1 in NRP2 depleted cell recovers the early endosomal structure
Supplementary figure legends from Rapalogs Efficacy Relies on the Modulation of Antitumor T-cell Immunity
Authors: Beziaud Laurent , Mansi Laura , Ravel Patrice , Marie-Joseph Elodie Lauret , Laheurte Caroline , Rangan Laurie , Bonnefoy Francis , Pallandre Jean-René , Boullerot Laura , Gamonet Clémentine , Vrecko Sindy , Queiroz Lise , Maurina Tristan , Mouillet Guillaume , Hon Thierry Nguyen Tan , Curtit Elsa , Royer Bernard , Gaugler Béatrice , Bayry Jagadeesh , Tartour Eric , Thiery-Vuillemin Antoine , Pivot Xavier , Borg Christophe , Godet Yann , Adotévi Olivier
Published: March 2023

This file contains the legends for the supplementary figures
Supplementary Table S1 from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors
Authors: Li Yong , Luo Shunqun , Ma Ruihua , Liu Jing , Xu Pingwei , Zhang Huafeng , Tang Ke , Ma Jingwei , Zhang Yi , Liang Xiaoyu , Sun Yanling , Ji Tiantian , Wang Ning , Huang Bo
Published: March 2023

Supplementary Table S1. List of RT-PCR primers used.
Supplementary Figure S1 from Rapalogs Efficacy Relies on the Modulation of Antitumor T-cell Immunity
Authors: Beziaud Laurent , Mansi Laura , Ravel Patrice , Marie-Joseph Elodie Lauret , Laheurte Caroline , Rangan Laurie , Bonnefoy Francis , Pallandre Jean-René , Boullerot Laura , Gamonet Clémentine , Vrecko Sindy , Queiroz Lise , Maurina Tristan , Mouillet Guillaume , Hon Thierry Nguyen Tan , Curtit Elsa , Royer Bernard , Gaugler Béatrice , Bayry Jagadeesh , Tartour Eric , Thiery-Vuillemin Antoine , Pivot Xavier , Borg Christophe , Godet Yann , Adotévi Olivier
Published: March 2023

this file contains the gating strategy: Supplementary figure 1
Supplementary Figure S4 from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors
Authors: Li Yong , Luo Shunqun , Ma Ruihua , Liu Jing , Xu Pingwei , Zhang Huafeng , Tang Ke , Ma Jingwei , Zhang Yi , Liang Xiaoyu , Sun Yanling , Ji Tiantian , Wang Ning , Huang Bo
Published: March 2023

Supplementary Figure S4. PCK1 knockdown did not affect the expression of metabolic enzymes in B16 TRCs.
Supplementary Figure S2 from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors
Authors: Li Yong , Luo Shunqun , Ma Ruihua , Liu Jing , Xu Pingwei , Zhang Huafeng , Tang Ke , Ma Jingwei , Zhang Yi , Liang Xiaoyu , Sun Yanling , Ji Tiantian , Wang Ning , Huang Bo
Published: March 2023

Supplementary Figure S2. The expression of PCK1 in CD133+ B16 cells, human primary melanoma TRCs and melanoma tissues.
Supplementary Figure S1 from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors
Authors: Li Yong , Luo Shunqun , Ma Ruihua , Liu Jing , Xu Pingwei , Zhang Huafeng , Tang Ke , Ma Jingwei , Zhang Yi , Liang Xiaoyu , Sun Yanling , Ji Tiantian , Wang Ning , Huang Bo
Published: March 2023

Supplementary Figure S1. The silence efficiency of siRNA against G9a, SUV39h1 or PCK1 and identification of constructs.
Supplementary Figure Legends from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors
Authors: Li Yong , Luo Shunqun , Ma Ruihua , Liu Jing , Xu Pingwei , Zhang Huafeng , Tang Ke , Ma Jingwei , Zhang Yi , Liang Xiaoyu , Sun Yanling , Ji Tiantian , Wang Ning , Huang Bo
Published: March 2023

Legends for Supplementary Figures S1-S8.
Supplemental Tables and Figures from EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape
Authors: Lim Seung-Oe , Li Chia-Wei , Xia Weiya , Lee Heng-Huan , Chang Shih-Shin , Shen Jia , Hsu Jennifer L. , Raftery Daniel , Djukovic Danijel , Gu Haiwei , Chang Wei-Chao , Wang Hung-Ling , Chen Mong-Liang , Huo Longfei , Chen Chung-Hsuan , Wu Yun , Sahin Aysegul , Hanash Samir M. , Hortobagyi Gabriel N. , Hung Mien-Chie
Published: March 2023

Supplementary Table 1. Relationships between expression of p-PKM2, EGFR and Ki-67 in surgical specimens of triple-negative breast cancer patients. Supplementary Table 2. Relationships between expression of p-PKM2, EGFR and Ki-67 in surgical specimens of non-triple-negative breast cancer patients. Supplementary Figure S1. EGF signaling enhances aerobic glycolysis in TNBC cells. Supplementary Figure S2. PKM2 is a novel binding partner of EGFR and its activity is inhibited by EGFR via Tyr phosphorylation. Supplementary Figure S3. EGFR reprograms cancer cell metabolism by PKM2 phosphorylation in TNBC cells. Supplementary Figure S4. Upregulation of HK2 expression by EGF signaling also contributes to aerobic glycolysis in TNBC cells. Supplementary Figure S5. Glycolysis metabolite, F1,6BP, binds directly to and enhances the activity of EGFR. Supplementary Figure S6. The combination of EGFR and glycolysis inhibitors synergistically suppresses TNBC cell proliferation. Supplementary Figure S7. EGF signaling-induced lactate inhibits cytotoxic T cell activity in TNBC cells.
Supplemental Materials and Methods from EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape
Authors: Lim Seung-Oe , Li Chia-Wei , Xia Weiya , Lee Heng-Huan , Chang Shih-Shin , Shen Jia , Hsu Jennifer L. , Raftery Daniel , Djukovic Danijel , Gu Haiwei , Chang Wei-Chao , Wang Hung-Ling , Chen Mong-Liang , Huo Longfei , Chen Chung-Hsuan , Wu Yun , Sahin Aysegul , Hanash Samir M. , Hortobagyi Gabriel N. , Hung Mien-Chie
Published: March 2023

Supplemental Materials and Methods
supplementary figure legends from The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling
Authors: Mansour Mariam , Haupt Sue , Chan Ai-Leen , Godde Nathan , Rizzitelli Alexandra , Loi Sherene , Caramia Franco , Deb Siddhartha , Takano Elena A. , Bishton Mark , Johnstone Cameron , Monahan Brendon , Levav-Cohen Yarra , Jiang Yong-Hui , Yap Alpha S. , Fox Stephen , Bernard Ora , Anderson Robin , Haupt Ygal
Published: March 2023

legends for supplemantry figures
Supplementary Methods and Tables from Peptide–Drug Conjugate GnRH–Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth
Authors: Argyros Orestis , Karampelas Theodoros , Asvos Xenophon , Varela Aimilia , Sayyad Nisar , Papakyriakou Athanasios , Davos Constantinos H. , Tzakos Andreas G. , Fokas Demosthenes , Tamvakopoulos Constantin
Published: March 2023

Supplementary Methods 1 - Overall Synthesis of sunitinib analogues (SAN1-SAN5) Supplementary Methods 2 - Computational analysis Supplementary Methods 3 - Synthesis of the conjugate SAN1GSC Supplementary Methods 4 - Biochemical Tyrosine Kinase Assay Supplementary Methods 5 - Cellular autophosphorylation assay Supplementary Methods 6 - Overall phenotypic health evaluation and monitoring of body weight Supplementary Methods 7 - Cardiotoxicity studies Supplementary Methods 8 - Blood toxicity Table S1 - List of GST- fusion proteins Table S2 - List of Antibodies
Supplementary Table S2 from Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma
Authors: Hirata Hidenari , Sugimachi Keishi , Komatsu Hisateru , Ueda Masami , Masuda Takaaki , Uchi Ryutaro , Sakimura Shotaro , Nambara Sho , Saito Tomoko , Shinden Yoshiaki , Iguchi Tomohiro , Eguchi Hidetoshi , Ito Shuhei , Terashima Kotaro , Sakamoto Katsumi , Hirakawa Masakazu , Honda Hiroshi , Mimori Koshi
Published: March 2023

Promoter methylation and copy number profiles of FBP1 in liver cancer cell lines from the Cancer Cell Line Encyclopedia.
Supplemental Table S2 from JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis
Authors: Li Na , Dhar Shilpa S. , Chen Tsai-Yu , Kan Pu-Yeh , Wei Yongkun , Kim Jae-Hwan , Chan Chia-Hsin , Lin Hui-Kuan , Hung Mien-Chie , Lee Min Gyu
Published: March 2023

ChiP primer sequences.
Legends for supplementary Figures from Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity
Authors: Ishiguro Tatsuya , Sato Ai , Ohata Hirokazu , Ikarashi Yoshinori , Takahashi Ryou-u , Ochiya Takahiro , Yoshida Masayuki , Tsuda Hitoshi , Onda Takashi , Kato Tomoyasu , Kasamatsu Takahiro , Enomoto Takayuki , Tanaka Kenichi , Nakagama Hitoshi , Okamoto Koji
Published: March 2023

Legends for supplementary Figures 1-5
Figures S1-S7 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types
Authors: Chartier Cecile , Raval Janak , Axelrod Fumiko , Bond Chris , Cain Jennifer , Dee-Hoskins Cristina , Ma Shirley , Fischer Marcus M. , Shah Jalpa , Wei Jie , Ji May , Lam Andrew , Stroud Michelle , Yen Wan-Ching , Yeung Pete , Cancilla Belinda , O'Young Gilbert , Wang Min , Kapoun Ann M. , Lewicki John , Hoey Timothy , Gurney Austin
Published: March 2023

Supplemental figures include the RSPO gene expression analysis for CRC models, the in vitro testing of anti-RSPO antibodies on RSPO-negative tumors, the IHC analysis of anti-RSPO3+chemo-treated ovarian tumors, the LGR, ZNRF3, and RNF43 gene expression profile in therapy responsive and non-responsive PDXs, the in vivo resistance of RSPO-negative tumors to RSPO blockade, the analysis of CSC frequency in anti-RSPO3-treated NSCL and pancreatic PDXs, and the IHC detection of CD44 in anti-RSPO3-treated CRC tumors.
Table S1 from Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases
Authors: Isozaki Hideko , Ichihara Eiki , Takigawa Nagio , Ohashi Kadoaki , Ochi Nobuaki , Yasugi Masayuki , Ninomiya Takashi , Yamane Hiromichi , Hotta Katsuyuki , Sakai Katsuya , Matsumoto Kunio , Hosokawa Shinobu , Bessho Akihiro , Sendo Toshiaki , Tanimoto Mitsune , Kiura Katsuyuki
Published: March 2023

Antibodies
Suppl. Figure 7 from Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases
Authors: Isozaki Hideko , Ichihara Eiki , Takigawa Nagio , Ohashi Kadoaki , Ochi Nobuaki , Yasugi Masayuki , Ninomiya Takashi , Yamane Hiromichi , Hotta Katsuyuki , Sakai Katsuya , Matsumoto Kunio , Hosokawa Shinobu , Bessho Akihiro , Sendo Toshiaki , Tanimoto Mitsune , Kiura Katsuyuki
Published: March 2023

Characteristics of ABC-11/CHR-r
Supplementary Figure S4 from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype
Authors: Li Ling , Li Chao , Wang Shaoxin , Wang Zhaohui , Jiang Jian , Wang Wei , Li Xiaoxia , Chen Jin , Liu Kun , Li Chunhua , Zhu Guiquan
Published: March 2023

Role of circulating exosomes on cell migration and invasion of OSCC cells.
Suppl. Figure 3 from Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases
Authors: Isozaki Hideko , Ichihara Eiki , Takigawa Nagio , Ohashi Kadoaki , Ochi Nobuaki , Yasugi Masayuki , Ninomiya Takashi , Yamane Hiromichi , Hotta Katsuyuki , Sakai Katsuya , Matsumoto Kunio , Hosokawa Shinobu , Bessho Akihiro , Sendo Toshiaki , Tanimoto Mitsune , Kiura Katsuyuki
Published: March 2023

Characteristics of the H2228 and H2228/CHR clones
Supplementary Table S2 from Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis
Authors: Ye Long-Yun , Chen Wei , Bai Xue-Li , Xu Xing-Yuan , Zhang Qi , Xia Xue-Feng , Sun Xu , Li Guo-Gang , Hu Qi-Da , Fu Qi-Han , Liang Ting-Bo
Published: March 2023

Univariate and multivariate analysis of factors associated with survival in HCC patients.
Supplemental Figure I from Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study
Authors: Schmitz Jennifer , Schwab Julian , Schwenck Johannes , Chen Qian , Quintanilla-Martinez Leticia , Hahn Markus , Wietek Beate , Schwenzer Nina , Staebler Annette , Kohlhofer Ursula , Aina Olulanu H. , Hubbard Neil E. , Reischl Gerald , Borowsky Alexander D. , Brucker Sara , Nikolaou Konstantin , la Fougère Christian , Cardiff Robert D. , Pichler Bernd J. , Schmid Andreas M.
Published: March 2023

Mean (blue) and maximal (red) ADC and [18F]FDG uptake values of the same representative 8 tumors: VOIs were drawn on the basis of the T2-weighted TSE MRI data, and transferred to the appropriate PET and ADC data. The mean and max values were determined. The comparison between mean or maximal values between the tumors revealed different trends.
Supplemental Data from Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes
Authors: McGrath John P. , Williamson Kaylyn E. , Balasubramanian Srividya , Odate Shobu , Arora Shilpi , Hatton Charlie , Edwards Thomas M. , O'Brien Thomas , Magnuson Steven , Stokoe David , Daniels Danette L. , Bryant Barbara M. , Trojer Patrick
Published: March 2023

Includes Supplementary Methods, Supplementary Tables and Figures and References Supplementary Figure 1: Structure and enzyme inhibitory activity of the KDM1A tool compounds. Supplementary Figure 2: CETSA shows thermal stabilization of KDM1A in intact cells following treatment with active KDM1A inhibitors. Supplementary Figure S3: Effects of RN-1 treatment on colony formation in methylcellulose. Supplementary Figure 4: KDM1A inhibition effects on the RUNX1-RUNX1T1 containing cell line SKNO-1. Supplementary Figure 5: Lack of global changes in histone H3K4 and H3K9 methylation following KDM1A inhibition. Supplementary Figure 6: KDM1A inhibitors affect KDM1A chromatin binding pattern in SKNO-1 cells. Supplementary Figure 7: Treatment of leukemia cells with a combination of KDM1A inhibitor RN-1 and EZH2 inhibitor CPI-169 leads to a synergistic cell killing in AML cell lines.
Supplemental Figure Legends from Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling
Authors: Yeo Syn Kok , Wen Jian , Chen Song , Guan Jun-Lin
Published: March 2023

Legend for Supplemental Figures S1-S4.
Supplemental Table1 from Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells
Authors: Choi Dongwon , Ramu Swapnika , Park Eunkyung , Jung Eunson , Yang Sara , Jung Wonhyeuk , Choi Inho , Lee Sunju , Kim Kyu Eui , Seong Young Jin , Hong Mingu , Daghlian George , Kim Daniel , Shin Eugene , Seo Jung In , Khatchadourian Vicken , Zou Mengchen , Li Wei , De Filippo Roger , Kokorowski Paul , Chang Andy , Kim Steve , Bertoni Ana , Furlanetto Tania Weber , Shin Sung , Li Meng , Chen Yibu , Wong Alex , Koh Chester , Geliebter Jan , Hong Young-Kwon
Published: March 2023

A concise summary of the publically available transcriptome data sets that were used to generate Figure 1 in the main text.
Supplemental Figure S5 from Identification of Bone-Derived Factors Conferring De Novo Therapeutic Resistance in Metastatic Prostate Cancer
Authors: Lee Yu-Chen , Lin Song-Chang , Yu Guoyu , Cheng Chien-Jui , Liu Bin , Liu Hsuan-Chen , Hawke David H. , Parikh Nila U. , Varkaris Andreas , Corn Paul , Logothetis Christopher , Satcher Robert L. , Yu-Lee Li-Yuan , Gallick Gary E. , Lin Sue-Hwa
Published: March 2023

Mouse body weights during treatments.
Supplementary figure 3 from Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
Authors: Rodriguez-Ruiz María E. , Rodriguez Inmaculada , Garasa Saray , Barbes Benigno , Solorzano Jose Luis , Perez-Gracia Jose Luis , Labiano Sara , Sanmamed Miguel F. , Azpilikueta Arantza , Bolaños Elixabet , Sanchez-Paulete Alfonso R. , Aznar M. Angela , Rouzaut Ana , Schalper Kurt A. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

Radiotherapy reduced the density and absolute numbers of CD4+, CD8+ and CD25+FOXP3+ T cells and Myeloid-derived suppressor cells both in the irradiated and non-irradiated lesions.
Supplementary figure 2 from Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
Authors: Rodriguez-Ruiz María E. , Rodriguez Inmaculada , Garasa Saray , Barbes Benigno , Solorzano Jose Luis , Perez-Gracia Jose Luis , Labiano Sara , Sanmamed Miguel F. , Azpilikueta Arantza , Bolaños Elixabet , Sanchez-Paulete Alfonso R. , Aznar M. Angela , Rouzaut Ana , Schalper Kurt A. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

4T1-derived spontaneous lung metastases
Supplemental Figure 5 TRIM3 effects on Importinβ1 nuclear localization and NICD binding. from Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Authors: Mukherjee Subhas , Tucker-Burden Carol , Zhang Changming , Moberg Kenneth , Read Renee , Hadjipanayis Costas , Brat Daniel J.
Published: March 2023

(A,B,C,D) N08-74 VC and 13113 VC both show more Importinβ1 nuclear localization than TRIM3 expressing N08-74 and 13113 cells, respectively. (E,F,G,H) NICD binds with Importin beta to a greater extent in TRIM3 null N08-74 and 13113 as compared to TRIM3 expressing N08-74 and 13113 cells, respectively. Scale bar: 5um.
Supplemental Figure 3 dNICD in Brat-RNAi brain localizes in nucleus. from Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Authors: Mukherjee Subhas , Tucker-Burden Carol , Zhang Changming , Moberg Kenneth , Read Renee , Hadjipanayis Costas , Brat Daniel J.
Published: March 2023

(A) Cytosolic extraction of brat-RNAi (bratIR) Drosophila brains shows higher levels of NICD compared to the control brain. (B) Nuclear extract also shows higher NICD in brat-RNAi compared to control suggesting increased NICD nuclear transport. (C) Densitometric quantification of nuclear NICD.
Supplementary Materials and Methods and Supplementary Figures 1 through 6 from Exome-Scale Discovery of Hotspot Mutation Regions in Human Cancer Using 3D Protein Structure
Authors: Tokheim Collin , Bhattacharya Rohit , Niknafs Noushin , Gygax Derek M. , Kim Rick , Ryan Michael , Masica David L. , Karchin Rachel
Published: March 2023

A detailed description of all methods, processing of mutations, and mapping to protein structure. Includes Fig S1 - Fig S6.
Supplementary data from Nkx2.8 Inhibits Epithelial–Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1
Authors: Yu Chunping , Liu Zhuowei , Chen Qiuhong , Li Yonghong , Jiang Lijuan , Zhang Zhiling , Zhou Fangjian
Published: March 2023

Supplemental figure legends and tables for sequences of primers
Figure S3 from Nkx2.8 Inhibits Epithelial–Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1
Authors: Yu Chunping , Liu Zhuowei , Chen Qiuhong , Li Yonghong , Jiang Lijuan , Zhang Zhiling , Zhou Fangjian
Published: March 2023

Silencing endogenous Nkx2.8 enhances the motility of UC cells
Supplemental Figure Legends from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Authors: Hall Zoe , Ament Zsuzsanna , Wilson Catherine H. , Burkhart Deborah L. , Ashmore Tom , Koulman Albert , Littlewood Trevor , Evan Gerard I. , Griffin Julian L.
Published: March 2023

Figure legends for supplemental Figures S1-S6.
Figure S6 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Authors: Hall Zoe , Ament Zsuzsanna , Wilson Catherine H. , Burkhart Deborah L. , Ashmore Tom , Koulman Albert , Littlewood Trevor , Evan Gerard I. , Griffin Julian L.
Published: March 2023

Multivariate statistics for eicosanoid profiles.
Figure S4 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Authors: Hall Zoe , Ament Zsuzsanna , Wilson Catherine H. , Burkhart Deborah L. , Ashmore Tom , Koulman Albert , Littlewood Trevor , Evan Gerard I. , Griffin Julian L.
Published: March 2023

Staining for proliferation and apoptosis before and after MYC deactivation.
Figure S6 from RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis
Authors: Lee Min-Goo , Jeong Seong-In , Ko Kyung-Phil , Park Soon-Ki , Ryu Byung-Kyu , Kim Ick-Young , Kim Jeong-Kook , Chi Sung-Gil
Published: March 2023

Figure S6. A Smurf1-dependency of RASSF1A suppression of RhoA-driven metastasis. A, The NOD/SCID mice were injected intravenously with A549-pcDNA or A549-RhoA (G14V) cells, which carry either shControl or shSmurf1 constructs. Metastatic nodules in the lungs were counted macroscopically after 20 days post-injection. Data represent the mean {plus minus} SD (n = 5 per group; **, P < 0.01).
Figure S5 from RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis
Authors: Lee Min-Goo , Jeong Seong-In , Ko Kyung-Phil , Park Soon-Ki , Ryu Byung-Kyu , Kim Ick-Young , Kim Jeong-Kook , Chi Sung-Gil
Published: March 2023

Figure S5. RASSF1A inhibits tumor-promoting activity of RhoA. A, RASSF1A regulation of cyclins and CDK inhibitors in a RhoA-dependent manner. B, Blockade of RhoA repression of p21WAF1 expression by WT-RASSF1A but not by RASSF1A-Î”256-277 and RASSF1A-Î”69-82. C, Inhibitory effect of WT-RASSF1A but not of RASSF1A-Î”256-277 and RASSF1A-Î”69-82 on EGF-induced DNA synthesis. DNA synthesis was measured by (3H)thymidine uptake assay after 24 h treatment. Data represent the mean {plus minus} SD (n = 3 experimental replicates; **, P < 0.01, Student t test). D, Flow cytometric assay of sub-G1 fraction showing no apoptotic activity of RASSF1A-R269F. E, RASSF1A inhibition of cell migration in a RhoA-dependent manner. Cell migration was compared at 18 h after artificial scratch. F, Matrigel assays showing blockade of EGF-induced tumor cell invasion by WT-RASSF1A but not by RhoA binding-deficient mutants (R269F and L266G). Data represent the mean {plus minus} SD (**, P < 0.01, Student t test). G, Time- and dose-dependent RhoA activation by TGF-Î²1 in DU145 cells. GTP-RhoA level was determined by GTPase pull-down assay using Rhotekin RBD-agarose. H, A crucial role for RhoA in TGF-Î²1-induced EMT in DU145 cells. The cells were transfected with siRhoA, siCdc42 or siRac1 and treated with TGF-Î²1(2 ng/ml, 48 h). I, Effect of RASSF1A or Smurf1 depletion on TGF-Î²1-induced EMT. HeLa and HaCaT cells transfected with siRASSF1A or siSmurf1 were treated with TGF-Î²1 (2 ng/ml, 48 h). TGF-Î²1-induced EMT was evaluated by microscopic analysis.
Figure S1-S12 from Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma
Authors: Xiao Weikun , Zhang Rongyu , Sohrabi Alireza , Ehsanipour Arshia , Sun Songping , Liang Jesse , Walthers Christopher M. , Ta Lisa , Nathanson David A. , Seidlits Stephanie K.
Published: March 2023

Supplementary figures S1-S12 providing necessary data on additional animal xenograft experiments, essential information characterizing cell lines used in manuscript, and controls for immunostaining and western blots. This supplementary file also provides data for experiment on additional cell lines.
Supplemental Figure 7 from JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma
Authors: Chan Tiffany Sin Yu , Hawkins Cynthia , Krieger Jonathan R. , McGlade C. Jane , Huang Annie
Published: March 2023

AKT inhibition does not alter JPO2 mRNA levels
Supplemental Figure 6 from JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma
Authors: Chan Tiffany Sin Yu , Hawkins Cynthia , Krieger Jonathan R. , McGlade C. Jane , Huang Annie
Published: March 2023

AKT inhibition does not alter survival of JPO2-expressing MB cells
Supplemental Figure 2 from JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma
Authors: Chan Tiffany Sin Yu , Hawkins Cynthia , Krieger Jonathan R. , McGlade C. Jane , Huang Annie
Published: March 2023

Effect of JPO2 on cell death induced by serum starvation, chemotherapeutics and radiation
Supplementary Figure Legends from An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell–like Behaviors Contributing to Disease Progression
Authors: Hayashi Hiromitsu , Higashi Takaaki , Yokoyama Naomi , Kaida Takayoshi , Sakamoto Keita , Fukushima Yukiko , Ishimoto Takatsugu , Kuroki Hideyuki , Nitta Hidetoshi , Hashimoto Daisuke , Chikamoto Akira , Oki Eiji , Beppu Toru , Baba Hideo
Published: March 2023

Supplementary Figure Legends
Supplemental methods and references from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis
Authors: Lang Michaela , Berry David , Passecker Katharina , Mesteri Ildiko , Bhuju Sabin , Ebner Florian , Sedlyarov Vitaly , Evstatiev Rayko , Dammann Kyle , Loy Alexander , Kuzyk Orest , Kovarik Pavel , Khare Vineeta , Beibel Martin , Roma Guglielmo , Meisner-Kober Nicole , Gasche Christoph
Published: March 2023

Additional information on mouse experiments, colonoscopy, histology, immunohistochemical analysis and amplicon sequencing for microbiota analysis
Supplemental figure 5 from An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell–like Behaviors Contributing to Disease Progression
Authors: Hayashi Hiromitsu , Higashi Takaaki , Yokoyama Naomi , Kaida Takayoshi , Sakamoto Keita , Fukushima Yukiko , Ishimoto Takatsugu , Kuroki Hideyuki , Nitta Hidetoshi , Hashimoto Daisuke , Chikamoto Akira , Oki Eiji , Beppu Toru , Baba Hideo
Published: March 2023

qPCR analysis of EpCAM, CD133, and CD44 expressions in response to TAZ knockdown.
Supplemental Figure 4: CRISPR/Cas9 HuR ko in RAW 264.7 macrophage cells. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis
Authors: Lang Michaela , Berry David , Passecker Katharina , Mesteri Ildiko , Bhuju Sabin , Ebner Florian , Sedlyarov Vitaly , Evstatiev Rayko , Dammann Kyle , Loy Alexander , Kuzyk Orest , Kovarik Pavel , Khare Vineeta , Beibel Martin , Roma Guglielmo , Meisner-Kober Nicole , Gasche Christoph
Published: March 2023

CRISPR/Cas9 HuR ko in RAW 264.7 macrophage cells confirmed by Sanger sequencing and Western blot analysis.
Supplemental Figure 2: Small intestinal crypt-villus length and HuR subcellular distribution in tumors. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis
Authors: Lang Michaela , Berry David , Passecker Katharina , Mesteri Ildiko , Bhuju Sabin , Ebner Florian , Sedlyarov Vitaly , Evstatiev Rayko , Dammann Kyle , Loy Alexander , Kuzyk Orest , Kovarik Pavel , Khare Vineeta , Beibel Martin , Roma Guglielmo , Meisner-Kober Nicole , Gasche Christoph
Published: March 2023

Crypt-villus length and HuR subcellular distribution as analyzed by immunohistochemistry and Western blot of nuclear and cytoplasmic fractions from isolated tumors in MS-444 treated and control mice.
Supplemental Figure 1: Weight curves, DSS water consumption, colonoscopy and tumor localization in APCMin mice. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis
Authors: Lang Michaela , Berry David , Passecker Katharina , Mesteri Ildiko , Bhuju Sabin , Ebner Florian , Sedlyarov Vitaly , Evstatiev Rayko , Dammann Kyle , Loy Alexander , Kuzyk Orest , Kovarik Pavel , Khare Vineeta , Beibel Martin , Roma Guglielmo , Meisner-Kober Nicole , Gasche Christoph
Published: March 2023

Weight curves of AOM/DSS and APCMin mice, DSS water consummtion and large bowel tumorigenesis in APCMin mice
Suppl. Figure 8 from HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
Authors: Budina-Kolomets Anna , Webster Marie R. , Leu Julia I-Ju , Jennis Matthew , Krepler Clemens , Guerrini Anastasia , Kossenkov Andrew V. , Xu Wei , Karakousis Giorgos , Schuchter Lynn , Amaravadi Ravi K. , Wu Hong , Yin Xiangfan , Liu Qin , Lu Yiling , Mills Gordon B. , Xu Xiaowei , George Donna L. , Weeraratna Ashani T. , Murphy Maureen E.
Published: March 2023

Melanoma cell lines with acquired resistance to BRAF inhibitors Cell viability analysis of the Yumm1.7 and WM983 melanoma cells treated with DMSO or the indicated doses of PLX4032 for 72 hours.
Supplementary Figure 3 from Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma
Authors: Cadamuro Massimiliano , Spagnuolo Gaia , Sambado Luisa , Indraccolo Stefano , Nardo Giorgia , Rosato Antonio , Brivio Simone , Caslini Chiara , Stecca Tommaso , Massani Marco , Bassi Nicolò , Novelli Eugenio , Spirli Carlo , Fabris Luca , Strazzabosco Mario
Published: March 2023

Supplementary Figure 3. In contrast with high doses, low dose PTX did not affect cell proliferation, viability, and apoptosis of CCA-TV3 cells.
Supplementary Figure Legends from DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster
Authors: Zagorac Sladjana , Alcala Sonia , Fernandez Bayon Gustavo , Bou Kheir Tony , Schoenhals Matthieu , González-Neira Anna , Fernandez Fraga Mario , Aicher Alexandra , Heeschen Christopher , Sainz Bruno
Published: March 2023

Legends for the supplemental figures.
Supplemental materials and methods from A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy
Authors: Makvandi Mehran , Xu Kuiying , Lieberman Brian P. , Anderson Redmond-Craig , Effron Samuel Sander , Winters Harrison D. , Zeng Chenbo , McDonald Elizabeth S. , Pryma Daniel A. , Greenberg Roger A. , Mach Robert H.
Published: March 2023

Supplemental material and methods.
Supplementary table 1 and 2 from Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1
Authors: Ann Eun-Jung , Kim Mi-Yeon , Yoon Ji-Hye , Ahn Ji-Seon , Jo Eun-Hye , Lee Hye-Jin , Lee Hyun-Woo , Kang Hyeok-Gu , Choi Dong Wook , Chun Kyung-Hee , Lee Ji Shin , Choi Cheol Yong , Ferrando Adolfo A. , Lee Keesook , Park Hee-Sae
Published: March 2023

Supplementary Table S1: Immunohistochemical staining of Notch1-IC and HIPK2 in serial tissue arrays of 61 breast cancer samples. Supplementary Table S2: Semi-Quantitative analysis of Notch1-IC, phosphorylated Notch1-IC T2512, HIPK2, and Fbw7 expression in breast cancer tissues.
Supplementary Table 1 from Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients
Authors: Wright Katherine L. , Adams Jessica R. , Liu Jeff C. , Loch Amanda J. , Wong Ruth G. , Jo Christine E.B. , Beck Lauren A. , Santhanam Divya R. , Weiss Laura , Mei Xue , Lane Timothy F. , Koralov Sergei B. , Done Susan J. , Woodgett James R. , Zacksenhaus Eldad , Hu Pingzhao , Egan Sean E.
Published: March 2023

Supplementary Table 1. Kaplan-Meier survival statistics for control and experimental mice: This table presents results of analysis on tumor assays.
Supplementary Figures, Results, and Methods from Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations
Authors: Lu Songjian , Cai Chunhui , Yan Gonghong , Zhou Zhuan , Wan Yong , Chen Vicky , Chen Lujia , Cooper Gregory F. , Obeid Lina M. , Hannun Yusuf A. , Lee Adrian V. , Lu Xinghua
Published: March 2023

Supplementary figures, results, and methods.
Supplementary Figures from S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma
Authors: Chow Kin-Hoe , Park Hee Jung , George Joshy , Yamamoto Keiko , Gallup Andrew D. , Graber Joel H. , Chen Yuanxin , Jiang Wen , Steindler Dennis A. , Neilson Eric G. , Kim Betty Y.S. , Yun Kyuson
Published: March 2023

Supplementary data showing expression and lontg-term self-renewal of S100A4+/GFP+ cells in spontaneous and transplanted tumors, including reactivation of S100A4 in S100A4-KD tumors. IPA and GSEA analyses showing pathways enriched in S100A4 expressing cells.
Supplementary Methods from Extracellular Matrix Receptor Expression in Subtypes of Lung Adenocarcinoma Potentiates Outgrowth of Micrometastases
Authors: Stevens Laura E. , Cheung William K.C. , Adua Sally J. , Arnal-Estapé Anna , Zhao Minghui , Liu Zongzhi , Brewer Kelly , Herbst Roy S. , Nguyen Don X.
Published: March 2023

Description in full of Supplementary Methods
Figure S1-S7 from Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress
Authors: Wang Jia Yu , Liu Guang Zhi , Wilmott James S. , La Ting , Feng Yu Chen , Yari Hamed , Yan Xu Guang , Thorne Rick F. , Scolyer Richard A. , Zhang Xu Dong , Jin Lei
Published: March 2023

Figure S1 shows the turnover rates of MTH1 mRNA remained similar between melanoma cells with relatively high (Mel-FH) and low (IgR3) expression of the transcript. Figure S2 shows silencing or overexpression of Skp2 did not alter the expression levels of the MTH1 transcript in melanoma cells. Figure S3 shows silencing of MTH1 did not impinge on the expression Skp2. Figure S4 shows Skp2-NES retains the ability to bind to MTH1. Figure S5 shows Skp2 silencing inhibits melanoma cell proliferation but does trigger apoptosis. Figure S6 shows the oxidative stress inducer elesclomol increases ROS levels. Figure S7 shows BRAF mutant melanoma cells selected for resistance to vemurafenib are more susceptible to killing by knockdown of Skp2 or MTH1.
Figure S2 from Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion
Authors: Liu Yongqiang , Yuelling Larra W. , Wang Yuan , Du Fang , Gordon Renata E. , O'Brien Jenny A. , Ng Jessica M.Y. , Robins Shannon , Lee Eric H. , Liu Hailong , Curran Tom , Yang Zeng-Jie
Published: March 2023

MB cells can not maintain Gli1 expression in vitro
Supplemental Table 1 from Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors
Authors: Valenti Giovanni , Quinn Hazel M. , Heynen Guus J.J.E. , Lan Linxiang , Holland Jane D. , Vogel Regina , Wulf-Goldenberg Annika , Birchmeier Walter
Published: March 2023

List of primers and antibodies used
Supplementary Figure Legends from Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells
Authors: Sampson Josephina , O'Regan Laura , Dyer Martin J.S. , Bayliss Richard , Fry Andrew M.
Published: March 2023

Supplementary figure legends
Figure S1 from Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells
Authors: Sampson Josephina , O'Regan Laura , Dyer Martin J.S. , Bayliss Richard , Fry Andrew M.
Published: March 2023

Figure S1 shows protein expression of Hsp72, Hsc70, Nek6 and Nek7 in different cell types following different treatments.