bluuebunny/crossref_metadata_2025 huggingface dataset:
Between Sound and Silence: The Failure of the “Symphony of Sirens” in Baku (1922) and Moscow (1923)
Authors: Schwartz Daniel
Published: May 2020

This article aims to temper the myth of the sound and scale of Arsenii Avraamov's city-wide mass spectacle the “Symphony of Sirens”—a myth that has been largely unquestioned in English-language sound and urban studies scholarship on the symphony. Instead of focusing solely on the symphony's dreaded noise, I pay attention to the symphony's silence—to the limits of what can be known about its sounds. Drawing on Avraamov's untranslated writings and personal correspondences, I investigate how the symphony's ideal of proletarian unity collides with the geographic, social, and sonic reality of the cities it sought to compose. I then investigate the roots of this ideal in Avraamov's personal aesthetic philosophy, as well as his idiosyncratic views on mechanical reproduction. This article will be of interest to those who wish to explore the connections between urbanism, colonialism, sound technology, the mass spectacle, and mass media in the Soviet musical avant-garde.
The Impact of SST on the Zonal Variability of the Western Pacific Subtropical High in Boreal Summer
Authors: Li Hong , Xu Fanghua , Lin Yanluan
Published: May 2020

Summertime western Pacific subtropical high (WPSH) is closely related to remote sea surface temperature anomalies (SSTA) in the tropical oceans (TO) and local SSTA in the western North Pacific (WNP). Based on atmospheric reanalysis and multimodel ensemble products, the warming (cooling) of the tropical Indian, tropical central‐eastern Pacific, and tropical Atlantic (tropical western Pacific and WNP) can lead to westward extension of the WPSH, and vice versa. A series of numerical experiments are conducted to quantify the relative importance of remote and local SSTA, including the separate impact of different TO basins. In response to warming (cooling) of the tropical Indian, tropical central‐eastern (western) Pacific, and tropical Atlantic, ascending (descending) motions develop locally and subsequently excite remote baroclinic and barotropic responses. The baroclinic anticyclone west of 140°E contributes to the westward extension of the WPSH. The barotropic anticyclone and descending motion over the WNP can further increase the sea level pressure and strengthen the WPSH. Based on the quasi‐geostrophic omega equation, we find that the anomalous vorticity advection (thermal advection) primarily accounts for the anomalous descending motion in response to remote (local) SSTA. Compared to local SSTA, the remote SSTA can induce larger perturbations, subsequently making the zonal variability of the WPSH more significant. Furthermore, it is found that the westward extension of the WPSH is primarily induced by atmospheric baroclinic (barotropic) response to the SSTA in tropical Indian and tropical Atlantic (tropical Pacific). Overall, the tropical Indian plays the most important role on the zonal movement of the WPSH.
Dynamic Driving Forces of India's Emissions From Production and Consumption Perspectives
Authors: Wang Zhenyu , Meng Jing , Guan Dabo
Published: May 2020

While India becomes one of the largest carbon emitters in the world with a high emission growth rate, existing studies fail to capture the recent trends and the key driving factors behind it. Here, by using multiregional input‐output analysis and structural decomposition analysis, we measure the contribution of factors to the changes of India's domestic consumption and trade‐related emissions. This study finds that India's per capita consumption has a significant raising effect on India's consumption‐based emissions during 2000–2014; increasing coal proportion (especially in industry and electricity) and ineffective energy efficiency (especially in electricity) continuously push India's production‐based emissions upwards after 2003. Meanwhile, India's domestic industrial chain shows increasing and decreasing effects on domestic consumption and export‐related emissions after 2011, respectively. India's forward industrial chain always drives export‐related emissions upwards. In addition, the major contributor of final demand in domestic consumption emissions transfers from capital investment to household consumption after 2008, while the increasing power of services in export‐related emissions rapidly fades in the same period. India's climbing import‐related emissions embodied in final products shift to light industries, and the intermediate products shift to heavy industries and constructions over time.
The emerging roles of WBP2 oncogene in human cancers
Authors: Tabatabaeian Hossein , Rao Angad , Ramos Alisha , Chu Tinghine , Sudol Marius , Lim Yoon Pin
Published: May 2020

WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI3K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.
Longer term follow-up of the randomized phase III trial SWOG S0777: bortezomib, lenalidomide and dexamethasone vs. lenalidomide and dexamethasone in patients (Pts) with previously untreated multiple myeloma without an intent for immediate autologous stem cell transplant (ASCT)
Authors: Durie Brian G. M. , Hoering Antje , Sexton Rachael , Abidi Muneer H. , Epstein Joshua , Rajkumar S. Vincent , Dispenzieri Angela , Kahanic Stephen P. , Thakuri Mohan C. , Reu Frederic J. , Reynolds Christopher M. , Orlowski Robert Z. , Barlogie Bart
Published: May 2020

SWOG S0777, a randomized phase III trial, compared bortezomib, lenalidomide and dexamethasone (VRd) with lenalidomide and dexamethasone (Rd). This updated analysis includes 460 patients evaluable for survival endpoints: 225 eligible and analyzable patients were randomized to Rd and 235 to VRd. The 6-month induction was six 28-day cycles of Rd and eight 21-day cycles of VRd followed by Rd maintenance for all patients. Median follow up is 84 months. Median PFS is 41 months for VRd and 29 months for Rd: stratified hazard ratio (96% Wald Confidence Interval) was 0.742 (0.594, 0.928) and one-sided stratified log-rankP-value 0.003. Median OS for VRd is still not reached with median OS for Rd being 69 months: stratified hazard ratio (96% Wald Confidence Interval) was 0.709 (0.543, 0.926) and stratified two-sidedP-value was 0.0114. Both PFS and OS were improved with VRd versus Rd adjusting for age (P-values: 0.013 [PFS]; 0.033 [OS])). Median duration of Rd maintenance was 17.1 months. The addition of bortezomib to lenalidomide dexamethasone for induction therapy results in a statistically significant and clinically meaningful improvement in PFS as well as better OS. VRd continues to represent an appropriate standard of care irrespective of age.
GALNT6 promotes invasion and metastasis of human lung adenocarcinoma cells through O-glycosylating chaperone protein GRP78
Authors: Song Jing , Liu Wenwen , Wang Jianzhen , Hao Junxia , Wang Yingyan , You Xin , Du Xiaohui , Zhou Yang , Ben Jing , Zhang Xinri , Ye Mingliang , Wang Qi
Published: May 2020

Lung adenocarcinoma remains a threat to human health due to its high rate of recurrence and distant metastasis. However, the molecular mechanism underlying lung adenocarcinoma metastasis remains yet incompletely understood. Here, we show that upregulated expression of polypeptide N-acetylgalactosaminyltransferase6 (GALNT6) in lung adenocarcinoma is associated with lymph node metastasis and poor prognosis. In lung adenocarcinoma cells, GALNT6 over-expression promoted epithelial–mesenchymal transition (EMT), wound healing, and invasion which could be significantly reversed by GALNT6 silencing. GALNT6 silencing also mitigated the metastasis of lung adenocarcinoma and prolonged the survival of xenograft tumor-bearing mice. Furthermore, GALNT6 directly interacted with, and O-glycosylated chaperone protein GRP78, which promoted EMT by enhancing the MEK1/2/ERK1/2 signaling in lung cancer cells. Therefore, GALNT6 is emerging as novel positive regulator for the malignancy of human lung adenocarcinoma. Targeting GALNT6-GRP78-MEK1/2/ERK1/2 may thus represent a new avenue to develop therapeutics against lung cancer metastasis.
SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression
Authors: Cao Nan , Yu Yali , Zhu Hua , Chen Meng , Chen Ping , Zhuo Mingxing , Mao Yujuan , Li Lianyun , Zhao Qiu , Wu Min , Ye Mei
Published: May 2020

SETDB1, a histone H3K9 methyltransferase, has been reported to be upregulated in a variety of tumors and promotes cancer development. However, the exact pathogenesis of SETDB1 in human colorectal cancer (CRC) is hitherto unknown. Here, we showed that SETDB1 expression was highly amplified in CRC. Functionally, SETDB1 downregulation in SW480 and HCT116 cells reduced cell proliferation, migration, invasion, and increased CRC cells apoptosis. In contrast, SETDB1 overexpression promoted CRC cells proliferation, migration, and invasion. High expression of SETDB1 was associated with a more aggressive phenotype in vitro. Flow cytometry showed that cell cycle was arrested in G1 phase after SETDB1 silencing. Furthermore, depletion of SETDB1 in vivo suppressed CRC cells proliferation. Mechanistically, p21 was identified as the target of SETDB1. After transfected with siSETDB1, expression of p21 was distinctly increased. In contrast, expression of p21 was significantly decreased after overexpression SETDB1. We also showed that SETDB1 could be involved in the regulation of epithelial–mesenchymal transition (EMT) in HCT116 cells. Moreover, we confirmed that SETDB1 could regulate the activity of p21 promoter by dual-luciferase repoter assay, and proved that SETDB1 could bind to the promoter of p21 and regulate its H3K9me3 enrichment level by ChIP-PCR experiment. Finally, we verified that silencing of SETDB1 inhibited CRC tumorigenesis in vivo. In conclusion, our results indicate that SETDB1 is a major driver of CRC development and might provide a new therapeutic target for the clinical treatment of CRC.
The micropeptide LEMP plays an evolutionarily conserved role in myogenesis
Authors: Wang Lantian , Fan Jing , Han Lili , Qi Haonan , Wang Yimin , Wang Hongye , Chen Suli , Du Lei , Li Sheng , Zhang Yunbin , Tang Wei , Ge Gaoxiang , Pan Weijun , Hu Ping , Cheng Hong
Published: May 2020

In recent years, micropeptides have been increasingly identified as important regulators in various biological processes. However, whether micropeptides are functionally conserved remains largely unknown. Here, we uncovered a micropeptide with evolutionarily conserved roles in myogenesis. RNA-seq data analysis of proliferating mouse satellite cells (SCs) and differentiated myotubes identified a previously annotated lncRNA, MyolncR4 (1500011K16RIK), which is upregulated during muscle differentiation. Significantly, MyolncR4 is highly conserved across vertebrate species. Multiple lines of evidence demonstrate that MyolncR4 encodes a 56-aa micropeptide, which was named as LEMP (lncRNA encoded micropeptide). LEMP promotes muscle formation and regeneration in mouse. In zebrafish, MyolncR4 is enriched in developing somites and elimination of LEMP results in impaired muscle development, which could be efficiently rescued by expression of the mouse LEMP. Interestingly, LEMP is localized at both the plasma membrane and mitochondria, and associated with multiple mitochondrial proteins, suggestive of its involvement in mitochondrial functions. Together, our work uncovers a micropeptide that plays an evolutionarily conserved role in skeletal muscle differentiation, pinpointing the functional importance of this growing family of small peptides.
Lipid-encapsulated siRNA for hepatocyte-directed treatment of advanced liver disease
Authors: Woitok Marius Maximilian , Zoubek Miguel Eugenio , Doleschel Dennis , Bartneck Matthias , Mohamed Mohamed Ramadan , Kießling Fabian , Lederle Wiltrud , Trautwein Christian , Cubero Francisco Javier
Published: May 2020

Lipid-based RNA nanocarriers have been recently accepted as a novel therapeutic option in humans, thus increasing the therapeutic options for patients. Tailored nanomedicines will enable to treat chronic liver disease (CLD) and end-stage liver cancer, disorders with high mortality and few treatment options. Here, we investigated the curative potential of gene therapy of a key molecule in CLD, the c-Jun N-terminal kinase-2 (Jnk2). Delivery to hepatocytes was achieved using a lipid-based clinically employable siRNA formulation that includes a cationic aminolipid to knockdownJnk2(namedsiJnk2). After assessing the therapeutic potential ofsiJnk2treatment, non-invasive imaging demonstrated reduced apoptotic cell death and improved hepatocarcinogenesis was evidenced by improved liver parenchyma as well as ameliorated markers of hepatic damage, reduced fibrogenesis in 1-year-old mice. Strikingly, chronicsiJnk2treatment reduced premalignant nodules, indicative of tumor initiation. Furthermore,siJnk2treatment led to a significant activation of the immune cell compartment. In conclusion,Jnk2knockdown in hepatocytes ameliorated hepatitis, fibrogenesis, and initiation of hepatocellular carcinoma (HCC), and hence might be a suitable therapeutic option, to define novel molecular targets for precision medicine in CLD.
A transition to stable one-dimensional swimming enhances E. coli motility through narrow channels
Authors: Vizsnyiczai Gaszton , Frangipane Giacomo , Bianchi Silvio , Saglimbeni Filippo , Dell’Arciprete Dario , Di Leonardo Roberto
Published: May 2020

Living organisms often display adaptive strategies that allow them to move efficiently even in strong confinement. With one single degree of freedom, the angle of a rotating bundle of flagella, bacteria provide one of the simplest examples of locomotion in the living world. Here we show that a purely physical mechanism, depending on a hydrodynamic stability condition, is responsible for a confinement induced transition between two swimming states inE. coli. While in large channels bacteria always crash onto confining walls, when the cross section falls below a threshold, they leave the walls to move swiftly on a stable swimming trajectory along the channel axis. We investigate this phenomenon for individual cells that are guided through a sequence of micro-fabricated tunnels of decreasing cross section. Our results challenge current theoretical predictions and suggest effective design principles for microrobots by showing that motility based on helical propellers provides a robust swimming strategy for exploring narrow spaces.
Extrinsic nature of the broad photoluminescence in lead iodide-based Ruddlesden–Popper perovskites
Authors: Kahmann Simon , Tekelenburg Eelco K. , Duim Herman , Kamminga Machteld E. , Loi Maria A.
Published: May 2020

Two-dimensional metal halide perovskites of Ruddlesden–Popper type have recently moved into the centre of attention of perovskite research due to their potential for light generation and for stabilisation of their 3D counterparts. It has become widespread in the field to attribute broad luminescence with a large Stokes shift to self-trapped excitons, forming due to strong carrier–phonon interactions in these compounds. Contrarily, by investigating the behaviour of two types of lead-iodide based single crystals, we here highlight the extrinsic origin of their broad band emission. As shown by below-gap excitation, in-gap states in the crystal bulk are responsible for the broad emission. With this insight, we further the understanding of the emission properties of low-dimensional perovskites and question the generality of the attribution of broad band emission in metal halide perovskite and related compounds to self-trapped excitons.
Prediction of organic homolytic bond dissociation enthalpies at near chemical accuracy with sub-second computational cost
Authors: St. John Peter C. , Guan Yanfei , Kim Yeonjoon , Kim Seonah , Paton Robert S.
Published: May 2020

Bond dissociation enthalpies (BDEs) of organic molecules play a fundamental role in determining chemical reactivity and selectivity. However, BDE computations at sufficiently high levels of quantum mechanical theory require substantial computing resources. In this paper, we develop a machine learning model capable of accurately predicting BDEs for organic molecules in a fraction of a second. We perform automated density functional theory (DFT) calculations at the M06-2X/def2-TZVP level of theory for 42,577 small organic molecules, resulting in 290,664 BDEs. A graph neural network trained on a subset of these results achieves a mean absolute error of 0.58 kcal mol−1 (vs DFT) for BDEs of unseen molecules. We further demonstrate the model on two applications: first, we rapidly and accurately predict major sites of hydrogen abstraction in the metabolism of drug-like molecules, and second, we determine the dominant molecular fragmentation pathways during soot formation.
Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia
Authors: Maas Dorien A. , Eijsink Vivian D. , Spoelder Marcia , van Hulten Josephus A. , De Weerd Peter , Homberg Judith R. , Vallès Astrid , Nait-Oumesmar Brahim , Martens Gerard J. M.
Published: May 2020

Impaired cognitive functioning is a core feature of schizophrenia, and is hypothesized to be due to myelination as well as interneuron defects during adolescent prefrontal cortex (PFC) development. Here we report that in the apomorphine-susceptible (APO-SUS) rat model, which has schizophrenia-like features, a myelination defect occurred specifically in parvalbumin interneurons. The adult rats displayed medial PFC (mPFC)-dependent cognitive inflexibility, and a reduced number of mature oligodendrocytes and myelinated parvalbumin inhibitory axons in the mPFC. In the developing mPFC, we observed decreased myelin-related gene expression that persisted into adulthood. Environmental enrichment applied during adolescence restored parvalbumin interneuron hypomyelination as well as cognitive inflexibility. Collectively, these findings highlight that impairment of parvalbumin interneuron myelination is related to schizophrenia-relevant cognitive deficits.
Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles
Authors: Halder Luke D. , Jo Emeraldo A. H. , Hasan Mohammad Z. , Ferreira-Gomes Marta , Krüger Thomas , Westermann Martin , Palme Diana I. , Rambach Günter , Beyersdorf Niklas , Speth Cornelia , Jacobsen Ilse D. , Kniemeyer Olaf , Jungnickel Berit , Zipfel Peter F. , Skerka Christine
Published: May 2020

Extracellular vesicles have an important function in cellular communication. Here, we show that human and mouse monocytes release TGF-β1-transporting vesicles in response to the pathogenic fungusCandida albicans. Soluble β-glucan fromC. albicansbinds to complement receptor 3 (CR3, also known as CD11b/CD18) on monocytes and induces the release of TGF-β1-transporting vesicles. CR3-dependence is demonstrated using CR3-deficient (CD11b knockout) monocytes generated by CRISPR-CAS9 genome editing and isolated from CR3-deficient (CD11b knockout) mice. These vesicles reduce the pro-inflammatory response in human M1-macrophages as well as in whole blood. Binding of the vesicle-transported TGF-β1 to the TGF-β receptor inhibitsIL1Btranscription via the SMAD7 pathway in whole blood and inducesTGFB1transcription in endothelial cells, which is resolved upon TGF-β1 inhibition. Notably, human complement-opsonized apoptotic bodies induce production of similar TGF-β1-transporting vesicles in monocytes, suggesting that the early immune response might be suppressed through this CR3-dependent anti-inflammatory vesicle pathway.
A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
Authors: Simoni Alekos , Hammond Andrew M. , Beaghton Andrea K. , Galizi Roberto , Taxiarchi Chrysanthi , Kyrou Kyros , Meacci Dario , Gribble Matthew , Morselli Giulia , Burt Austin , Nolan Tony , Crisanti Andrea
Published: May 2020

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control methods that bias the sex ratio of insect offspring have long been sought. Genetic elements such as sex-chromosome drives can distort sex ratios to produce unisex populations that eventually collapse, but the underlying molecular mechanisms are unknown. We report a male-biased sex-distorter gene drive (SDGD) in the human malaria vectorAnopheles gambiae. We induced super-Mendelian inheritance of the X-chromosome-shredding I-PpoI nuclease by coupling this to a CRISPR-based gene drive inserted into a conserved sequence of thedoublesex(dsx) gene. In modeling of invasion dynamics, SDGD was predicted to have a quicker impact on female mosquito populations than previously developed gene drives targeting female fertility. The SDGD at thedsxlocus led to a male-only population from a 2.5% starting allelic frequency in 10–14 generations, with population collapse and no selection for resistance. Our results support the use of SDGD for malaria vector control.
Author Correction: Quantitative phase contrast imaging of a shock-wave with a laser-plasma based X-ray source
Authors: Barbato F. , Atzeni S. , Batani D. , Bleiner D. , Boutoux G. , Brabetz C. , Bradford P. , Mancelli D. , Neumayer P. , Schiavi A. , Trela J. , Volpe L. , Zeraouli G. , Woolsey N. , Antonelli L.
Published: May 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Layer 4 pyramidal neuron dendritic bursting underlies a post-stimulus visual cortical alpha rhythm
Authors: Traub Roger D. , Hawkins Karen , Adams Natalie E. , Hall Stephen P. , Simon Anna , Whittington Miles A.
Published: May 2020

Alpha rhythms (9–11 Hz) are a dominant feature of EEG recordings, particularly over occipital cortex on cessation of a visual stimulation. Little is known about underlying neocortical mechanisms so here we constructed alpha rhythm models that follow cessation of cortical stimulation. The rhythm manifests following a period of gamma frequency activity in local V1 networks in layer 4. It associates with network level bias of excitatory synaptic activity in favour of NMDA- rather than AMPA-mediated signalling and reorganisation of synaptic inhibition in favour of fast GABAA receptor-mediated events. At the cellular level the alpha rhythm depended upon the generation of layer 4 pyramidal neuron dendritic bursting mediated primarily by PPDA-sensitive NR2C/D-containing NMDA receptors, which lack the magnesium-dependent open channel block. Subthreshold potassium conductances are also critical. The rhythm dynamically filters outputs from sensory relay neurons (stellate neurons in layer 4) such that they become temporally uncoupled from downstream population activity.
Crop and forest pest metawebs shift towards increased linkage and suitability overlap under climate change
Authors: Grünig Marc , Mazzi Dominique , Calanca Pierluigi , Karger Dirk Nikolaus , Pellissier Loïc
Published: May 2020

Global changes pose both risks and opportunities to agriculture and forestry, and biological forecasts can inform future management strategies. Here, we investigate potential land-use opportunities arising from climate change for these sectors in Europe, and risks associated with the introduction and establishment of novel insect pests. Adopting a metaweb approach including all interaction links between 126 crops and forest tree species and 89 black-listed insect pest species, we show that the metawebs shift toward increased numbers of links and overlap of suitable area under climate change. Decomposing the metaweb across regions shows large saturation in southern Europe, while many novel interactions are expected for northern Europe. In light of the rising consumer awareness about human health and environmental impacts of food and wood production, the challenge will be to effectively exploit new opportunities to create diverse local agriculture and forestry while controlling pest species and reducing risks from pesticide use.
Author Correction: Enhancing catalytic performance of dilute metal alloy nanomaterials
Authors: Luneau Mathilde , Guan Erjia , Chen Wei , Foucher Alexandre C. , Marcella Nicholas , Shirman Tanya , Verbart David M. A. , Aizenberg Joanna , Aizenberg Michael , Stach Eric A. , Madix Robert J. , Frenkel Anatoly I. , Friend Cynthia M.
Published: May 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Design of a debinding process for polymetallic material green parts fabricated via metal paste injection 3D printing with dual nozzles
Authors: Gong Ping , Yan Xiaokang , Xiong Wei , Hao Liang , Tang Danna , Li Yan
Published: May 2020

An innovative approach to the control mechanism of the MPI debinding process, also proving the feasibility of manufacturing polymetallic material parts.
Cationic liposome-triggered luminol chemiluminescence reaction and its applications
Authors: Huang Yongxin , Yue Ningning , Fan Aiping
Published: May 2020

Cationic liposomes show catalytic activity on luminol-H2O2 chemiluminescence reaction which was applied to establish label-free sensing platforms.
Nanohybrid carriers: the yin–yang equilibrium between natural and synthetic in biomedicine
Authors: Ghorbanizamani Faezeh , Moulahoum Hichem , Zihnioglu Figen , Timur Suna
Published: May 2020

Nanocarriers are key players in biomedicine applications. The development of hybrid nanoparticles stems from the need to enhance their quality by lowering disadvantages and fusing the positive qualities of both natural and synthetic materials.
Wound healing properties of magnesium mineralized antimicrobial nanofibre dressings containing chondroitin sulphate – a comparison between blend and core–shell nanofibres
Authors: Leung Chak Ming , Dhand Chetna , Mayandi Venkatesh , Ramalingam Raghavendra , Lim Fui Ping , Barathi Veluchamy Amutha , Dwivedi Neeraj , Orive Gorka , Beuerman Roger W. , Ramakrishna Seeram , Toh Yi-Chin , Loh Xian Jun , Verma Navin Kumar , Chua Alvin Wen Choong , Lakshminarayanan Rajamani
Published: May 2020

Effect of chondroitin sulphate incorporated PCL/gelatin as blends or core–shell composite nanofibres are compared in terms of their biocompatibility for skin cells and wound healing in porcine model of partial thickness burns.
FeMoO4 nanorods for efficient ambient electrochemical nitrogen reduction
Authors: Wu Jie , Wang ZhongXu , Li Siwei , Niu Siqi , Zhang Yuanyuan , Hu Jing , Zhao Jingxiang , Xu Ping
Published: May 2020

FeMoO4 nanorods exhibit outstanding electrocatalytic activity, selectivity and stability for nitrogen reduction reaction (NRR).
Cellular microparticles for tumor targeting delivery: from bench to bedside
Authors: Zhang Zhijie , Xiao Chen , Yong Tuying , Yang Xiangliang , Gan Lu , Li Zifu
Published: May 2020

This feature article summarizes the progress in leveraging microparticles for tumor targeting delivery, from bench to bedside.
Metal removal from the secondary building unit of bio-MOF-1 by adenine N6-alkylation while retaining the overall 3D porous topology
Authors: García-Raso Angel , Terrón Angel , Roselló Yannick , Frontera Antonio , Castillo Oscar , Beobide Garikoitz , Pérez-Yáñez Sonia , Escudero-Adán Eduardo C. , Fiol Juan J.
Published: May 2020

A novel approach to modify the SBU of bio-MOF-1 by reducing the nuclearity of the metal cluster while retaining the topology of the anionic 3D framework is reported.
Reaction uniformity visualized by Raman imaging in the composite electrode layers of all-solid-state lithium batteries
Authors: Otoyama Misae , Ito Yusuke , Sakuda Atsushi , Tatsumisago Masahiro , Hayashi Akitoshi
Published: May 2020

The reaction uniformity of LiCoO2 composite positive electrodes in all-solid-state cells was compared quantitatively by investigating the Raman band shifts corresponding to the state-of-charge (SOC) of LiCoO2.
Thermal stability mechanism via energy absorption by chemical bonds bending and stretching in free space and the interlayer reaction of layered molecular structure explosives
Authors: Zhang Kaining , Chen Lang , Geng Deshen , Lu Jianying , Wu Junying
Published: May 2020

Layered molecular structure explosives have the characteristic of great thermal stability.
In situ and sensitive monitoring of configuration-switching involved dynamic adsorption by surface plasmon-coupled directional enhanced Raman scattering
Authors: Pan Xiao-Hui , Cao Shuo-Hui , Chen Min , Zhai Yan-Yun , Xu Zi-Qian , Ren Bin , Li Yao-Qun
Published: May 2020

Surface plasmon-coupled directional enhanced Raman scattering is utilized to monitor the configuration switching-related dynamic adsorption isotherms in situ and sensitively.
Impact of binding to the multidrug resistance regulator protein LmrR on the photo-physics and -chemistry of photosensitizers
Authors: Mejías Sara H. , Roelfes Gerard , Browne Wesley R.
Published: May 2020

Binding of photosensitizing compounds to the LmrR protein with and without tryptophan residues has a profound and varied effect on their photochemistry and ability to generate reactive oxygen species.
Two new estertin modified tungstosilicates: synthesis, catalytic activity and photoelectrochemical property
Authors: Zhang Yao , Li Meng-Xuan , Hao Qiang , Su Fang , Zhu Zai-Ming , Li Jian-Sheng , Sang Xiao-Jing , Wang Chang-Sheng , Zhang Lan-Cui
Published: May 2020

Two estertin functionalized tungstosilicates were synthesized and analyzed by DFT. They exhibit good photoelectrocatalytic performance for oxidation of methanol.
The leaving group in Au(i)–phosphine compounds dictates cytotoxic pathways in CEM leukemia cells and reactivity towards a Cys2His2 model zinc finger
Authors: de Paiva Raphael E. F. , Peterson Erica J. , Du Zhifeng , Farrell Nicholas P.
Published: May 2020

The leaving group L in [(R3P)AuL]n+ regulates the cytotoxic mechanism against CEM leukemia cells and the reactivity towards Sp1 ZnF3.
Emerging investigator series: engineering membrane distillation with nanofabrication: design, performance and mechanisms
Authors: Huang Rui , Liu Zhiquan , Woo Yun Chul , Luo Wenhai , Gray Stephen R. , Xie Ming
Published: May 2020

Anti-fouling and durability are two important parameters that are closely associated with the development and deployment of membrane distillation (MD).
The influence of oil composition on the transformation, bioaccessibility, and intestinal absorption of curcumin in nanostructured lipid carriers
Authors: Feng Jin , Huang Meigui , Chai Zhi , Li Chunyang , Huang Wuyang , Cui Li , Li Ying
Published: May 2020

The influences of MCT (liquid) and GTS (solid) contents in the lipid matrix of NLCs on their delivering capacities with respect to curcumin were investigated by using a simulated gastrointestinal tract and Caco-2 monolayer models.
A two-fold engineering approach based on Bi2Te3 flakes towards efficient and stable inverted perovskite solar cells
Authors: Tsikritzis Dimitris , Rogdakis Konstantinos , Chatzimanolis Konstantinos , Petrović Miloš , Tzoganakis Nikos , Najafi Leyla , Martín-García Beatriz , Oropesa-Nuñez Reinier , Bellani Sebastiano , Del Rio Castillo Antonio Esaù , Prato Mirko , Stylianakis Minas M. , Bonaccorso Francesco , Kymakis Emmanuel
Published: May 2020

An engineering approach is implemented for the performance and stability enhancement of perovskite solar cells, through the incorporation of bismuth telluride flakes in the electron transport layer (ETL) and as an interlayer on top of the ETL.
Nanocrystalline microstructure in Sm3+ and Gd3+ doped K2O–MgO–Al2O3–SiO2–F glass-ceramic sealant (SOFC)
Authors: Garai Mrinmoy , Rao C. Hari Venkateswara , Karmakar Basudeb
Published: May 2020

In order to demonstrate the effects of Sm3+ and Gd3+ ions on the crystalline microstructures of the magnesium-boro-alumino-silicate (MBAS) system, the K2O–MgO–B2O3–Al2O3–SiO2–F glass doped with 0–5 mol% Sm2O3 and Gd2O3 were synthesized by melt-quenching (1550 °C).
Transformation of herbicides into dual function quaternary tropinium salts
Authors: Parus Anna , Wilms Wiktoria , Verkhovetska Viktoriia , Framski Grzegorz , Woźniak-Karczewska Marta , Syguda Anna , Strzemiecka Beata , Borkowski Andrzej , Ławniczak Łukasz , Chrzanowski Łukasz
Published: May 2020

Quaternary tropinium salts as novel, efficient herbicides and plant-growth promoting agents in case of crops.
Ergocytochalasin A, a polycyclic merocytochalasan from an endophytic fungus Phoma multirostrata XJ-2-1
Authors: Peng Xiaogang , Duan Fangfang , He Yangzhou , Gao Ying , Chen Juan , Chang Jinling , Ruan Hanli
Published: May 2020

Ergocytochalasin A (1), an unprecedented merocytochalasan with a 5/6/14/6/5/6/6/6 fused octacyclic ring system, was isolated from an endophytic fungus Phoma multirostrata XJ-2-1.
Synthetic approaches towards cortistatins: evolution and progress through its ages
Authors: Indu Satrajit , Kaliappan Krishna P.
Published: May 2020

With an exhaustive coverage of all the synthetic approaches towards cortistatins, this review serves to assemble most of the avenues which have been employed to conquer this complex steroidal alkaloid architecture.
FeCl2 catalyzed direct modification of dihydropyrrolo[2,1-a]isoquinolines with phenols
Authors: Cui Hai-Lei
Published: May 2020

A mild FeCl2 catalyzed direct modification of dihydropyrrolo[2,1-a]isoquinolines with phenols via heteroarene cation radical transformations has been developed (up to 98% yield).
Polymerization techniques in polymerization-induced self-assembly (PISA)
Authors: Liu Chao , Hong Chun-Yan , Pan Cai-Yuan
Published: May 2020

The development of controlled/“living” polymerization greatly stimulated the prosperity of the fabrication and application of block copolymer nano-objects.
A metal-free synthesis of 1,1-diphenylvinylsulfides with thiols via thioetherification under continuous-flow conditions
Authors: Zhang Jiawei , Wang Erfei , Zhou Yang , Zhang Lu , Chen Mao , Lin Xinrong
Published: May 2020

A continuous-flow chemistry facilitated protocol that allows efficient access to a novel aggregation-induced emission (AIE) luminogen 1,1-diphenylvinylsulfides utilizing thiols under metal-free and mild conditions.
Mass spectrometric analysis of acid-assisted photochemical release of the trimethyl lock system on the monolayers on gold
Authors: Yu Geunhyeok , Yeo Woon-Seok
Published: May 2020

The acid-assisted photolysis of the trimethyl lock on the surface was characterized by mass spectrometry.
Dispersion-induced structural preference in the ultrafast dynamics of diphenyl ether
Authors: Wang Lian , Zhang Song , Wang Ye , Zhang Bing
Published: May 2020

Dispersion interactions are omnipresent in large aromatic systems and influence the dynamics as intermolecular forces.
Polydopamine-doped virus-like structured nanoparticles for photoacoustic imaging guided synergistic chemo-/photothermal therapy
Authors: Zhong Rong , Wang Ruoping , Hou Xuemei , Song Liang , Zhang Yun
Published: May 2020

The therapeutic diagnosis effect of cancer commonly depends on the cellular uptake efficiency of nanomaterials.
A highly unsaturated six-vertex amido-substituted silicon cluster
Authors: Keuter Jan , Schwermann Christian , Hepp Alexander , Bergander Klaus , Droste Jörn , Hansen Michael Ryan , Doltsinis Nikos L. , Mück-Lichtenfeld Christian , Lips Felicitas
Published: May 2020

Thermal treatment of the bicyclo[1.1.0]tetrasilatetraamide [Si4{N(SiMe3)Dipp}4]1resulted in the formation of a highly unsaturated six-vertex silicon cluster [Si6{N(SiMe3)Dipp}4]2with only four amine-substituents and two ligand-free silicon atoms.
A N, O co-doped hierarchical carbon cathode for high-performance Zn-ion hybrid supercapacitors with enhanced pseudocapacitance
Authors: Deng Xiaoyang , Li Jiajun , Shan Zhu , Sha Junwei , Ma Liying , Zhao Naiqin
Published: May 2020

A novel carbon cathode was fabricated for high-performance Zn-ion supercapacitors with enhanced pseudocapacitance.
Towards photovoltaic windows: scalable fabrication of semitransparent modules based on non-fullerene acceptors via laser-patterning
Authors: Pascual-San-José Enrique , Sadoughi Golnaz , Lucera Luca , Stella Marco , Martínez-Ferrero Eugenia , Morse Graham Edward , Campoy-Quiles Mariano , Burgués-Ceballos Ignasi
Published: May 2020

We use state-of-the-art absorbing materials and industrially compatible processing techniques and conditions to fabricate semitransparent organic photovoltaic (OPV) module prototypes that exceed 30% transparency.
Surface functionalization of ZnO:Ag columnar thin films with AgAu and AgPt bimetallic alloy nanoparticles as an efficient pathway for highly sensitive gas discrimination and early hazard detection in batteries
Authors: Vahl Alexander , Lupan Oleg , Santos-Carballal David , Postica Vasile , Hansen Sandra , Cavers Heather , Wolff Niklas , Terasa Maik-Ivo , Hoppe Mathias , Cadi-Essadek Abdelaziz , Dankwort Torben , Kienle Lorenz , de Leeuw Nora H. , Adelung Rainer , Faupel Franz
Published: May 2020

This work presents the impact of surface decoration on the VOC sensing properties of ZnO:Ag columnar films by AgPt and AgAu bimetallic alloy nanoparticles.
Improved quantum efficiency in an engineered light harvesting/photosystem II super-complex for high current density biophotoanodes
Authors: Hartmann Volker , Harris Dvir , Bobrowski Tim , Ruff Adrian , Frank Anna , Günther Pomorski Thomas , Rögner Matthias , Schuhmann Wolfgang , Adir Noam , Nowaczyk Marc M.
Published: May 2020

Integration of a 10 MDa light-harvesting photosystem II super-complex into macro-puorous indium tin oxide biophotoanodes for improved energy conversion.
3D Bioprinting of shear-thinning hybrid bioinks with excellent bioactivity derived from gellan/alginate and thixotropic magnesium phosphate-based gels
Authors: Chen You , Xiong Xiong , Liu Xin , Cui Rongwei , Wang Chen , Zhao Guoru , Zhi Wei , Lu Mengjie , Duan Ke , Weng Jie , Qu Shuxin , Ge Jianhua
Published: May 2020

A novel shear-thinning hybrid bioink with good printability, mechanical support, biocompatibility, and bioactivity was developed by combining gellan gum, sodium alginate, and thixotropic magnesium phosphate-based gel (GG–SA/TMP-BG).
Suppressing the negative temperature coefficient effect of resistance in polymer composites with positive temperature coefficients of resistance by coating with parylene
Authors: Okutani Chihiro , Yokota Tomoyuki , Matsukawa Ryotaro , Someya Takao
Published: May 2020

Thin parylene coating suppressed the negative temperature coefficient (NTC) effect of polymer thermistors with a positive temperature coefficient (PTC) while maintaining the PTC characteristics.
On the growth, structure and dynamics of P3EHT crystals
Authors: C. Faria Gregório , Duong Duc T. , da Cunha Giovanni Paro , Selter Philipp , Strassø Lasse Arnt , Davidson Emily C. , Segalman Rachel A. , Hansen Michael Ryan , deAzevedo Eduardo Ribeiro , Salleo Alberto
Published: May 2020

We employ X-ray diffraction, NMR and UV-vis spectroscopy techniques to shed light on the structure, molecular mobility and crystallization of a prototypical semiconducting polymer poly(3-(2′-ethylhexyl)thiophene) (P3EHT).
A transparent and adhesive carboxymethyl cellulose/polypyrrole hydrogel electrode for flexible supercapacitors
Authors: Cheng Ya , Ren Xiuyan , Duan Lijie , Gao Guanghui
Published: May 2020

The transparent, UV-shielding and adhesive carboxymethyl cellulose/polypyrrole hydrogel was designed to develop the flexible supercapacitor electrode.
Ideal alloys of two donor isomers with non-covalently conformational locking for ternary organic solar cells
Authors: Deng Dan , Zhang Hao , Wu Qiong , Adil Muhammad Abdullah , Yang Chen , Zhang Jianqi , Wei Zhixiang
Published: May 2020

Two isomers with distinct properties were synthesized by tuning conformational locking positions. The isomers formed an ideal alloy, blending with PC71BM, an improvement of 76% in PCE was obtained in ternary OSCs compared with binary counterparts.
Realization of deep-blue TADF in sterically controlled naphthyridines for vacuum- and solution-processed OLEDs
Authors: Kreiza Gediminas , Banevičius Dovydas , Jovaišaitė Justina , Juršėnas Saulius , Javorskis Tomas , Vaitkevičius Vytenis , Orentas Edvinas , Kazlauskas Karolis
Published: May 2020

Efficient deep-blue naphthyridine-based TADF emitters featuring narrow-band-emission with low roll-off were designed by using the H-bonding and sterically controlled charge-transfer interactions.
Computationally designed synthetic peptides for transporter proteins imparts allostericity in Miltefosine resistantL. major
Authors: Kabra Ritika , Ingale Prajakta , Singh Shailza
Published: May 2020

The emergence of drug resistance is a major concern for combating against Cutaneous Leishmaniasis, a neglected tropical disease affecting 98 countries including India. Miltefosine is the only oral drug available for the disease and Miltefosine transporter proteins play a pivotal role in the emergence of drug-resistant Leishmania major. The cause of resistance is less accumulation of drug inside the parasite either by less uptake of the drug due to a decrease in the activity of P4ATPase–CDC50 complex or by increased efflux of the drug by P-glycoprotein (P-gp, an ABC transporter). In this paper, we are trying to allosterically modulate the behavior of resistant parasite (L. major) towards its sensitivity for the existing drug (Miltefosine, a phosphatidylcholine analog). We have used computational approaches to deal with the conservedness of the proteins and apparently its three-dimensional structure prediction through ab initio modeling. Long scale membrane-embedded molecular dynamics simulations were carried out to study the structural interaction and stability. Parasite-specific motifs of these proteins were identified based on the machine learning technique, against which a peptide library was designed. The protein–peptide docking shows good binding energy of peptides Pg5F, Pg8F and PC2 with specific binding to the motifs. These peptides were tested both in vitro and in vivo, where Pg5F in combination with PC2 showed 50–60% inhibition in resistant L. major's promastigote and amastigote forms and 80–90% decrease in parasite load in mice. We posit a model system wherein the data provide sufficient impetus for being novel therapeutics in order to counteract the drug resistance phenotype in Leishmania parasites.
The roles of MASPIN expression and subcellular localization in non-small cell lung cancer
Authors: Wang Xiao-Fei , Liang Bo , Zeng Da-Xiong , Lei Wei , Chen Cheng , Chen Yan-Bin , Huang Jian-An , Gu Ning , Zhu Ye-Han
Published: May 2020

Accumulating studies have confirmed that mammary serine protease inhibitor (MASPIN) plays an essential role in non-small cell lung cancer (NSCLC). However, results are still controversial or inconsistent. In the present study, we attempted to identify the clinical significance of MASPIN and its potential molecular roles in NSCLC. The correlation of MASPIN with prognosis and clinicopathological characteristics was assessed by meta-analysis. Additionally, the potential molecular mechanisms of MASPIN in NSCLC was also investigated through several online databases. A total of 2220 NSCLC patients from 12 high quality studies were included and the results indicated that up-regulated MASPIN nucleus and cytoplasm expression was associated with poor overall survival (OS) (hazard ratio (HR) = 1.43, 95% confidence interval (CI) = 1.01–2.04, P<0.05), elevated MASPIN cytoplasm expression was associated with poor OS (HR = 1.45, 95% CI = 1.01–2.07, P<0.05), disease-free survival (DFS) (HR = 1.95, 95% CI = 1.31–2.88, P=0.001), and disease-specific survival (DSS) (HR = 2.17, 95% CI = 1.18–3.99, P=0.013). MASPIN both nucleus and cytoplasm location were associated with clinicopathological characteristics. Bioinformatics analysis validated the above results and suggested that human serpin family B member 5 (SERPINB5) hypomethylated levels were negatively correlated with its mRNA expression. Bioinformatics analysis also revealed the 85 most frequently altered neighboring genes of SERPINB5, and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed 20 GO terms and 3 KEGG pathways with statistical significance. MASPIN had a statistically negative correlation with NSCLC prognosis, functioning as an oncoprotein by hypomethylation and influencing specific pathways involving the 85 genes identified herein. MASPIN might be a promising prognostic signature in NSCLC.
Communication Profile of a Minimally Verbal School-Age Autistic Child: A Case Study
Authors: Vidal Verónica , McAllister Anita , DeThorne Laura
Published: May 2020

Purpose

The present clinical focus draws on an intrinsic case study to provide a thick description of the communication profile of John, a 9-year-old minimally verbal autistic student.

Method

Specifically, traditional behavioral assessments, classroom video observations, and semistructured interviews were used to gather information regarding John's communication profile and potential sensory–motor differences.

Results

Convergent evidence indicated that John's expressive profile was characterized by single words, emergent word combinations, some conventional gestures, and a low frequency of communicative initiations. Concomitant language comprehension challenges and poor intelligibility associated with motor speech impairment were also indicated. His sensory–motor profile was marked by fine motor impairment, relative strengths in gross motor abilities, and sensory differences across visual, hearing, and tactile modalities.

Conclusion

Direct implications for supporting minimally verbal autistic students like John include the need to (a) consider sensory–motor influences on social interaction and (b) support flexible use of multimodal communication resources, including augmentative and alternative communication.

Supplemental Material

https://doi.org/10.23641/asha.12202448
Neue Kraft für ein krankes Herz
Authors: Schweitzer Carina
Published: May 2020

Mechanische Herzkreislaufunterstützungssysteme trotzen dem vorhandenen Organmangel, indem sie Menschen mit terminaler Herzinsuffizienz eine geeignete Alternative zur etablierten Herztransplantation bieten. Durch die steigende Inzidenz der refraktären Herzinsuffizienz gewinnen sogenannte „Ventricular Assist Device“-Systeme in der intensivmedizinischen Praxis zunehmend an Bedeutung. Der folgende Beitrag beleuchtet die Grundlagen zu den aktuellen mechanischen Kreislaufunterstützungssystemen hinsichtlich der Pathophysiologie, Therapie und allgemeinen Fakten. Im Mittelpunkt steht das biventrikuläre Herzunterstützungssystem Berlin Heart EXCOR®.
Erfolgreiche Therapie einer Sarkoidose mit TNF-alpha-Antagonisten
Authors: Heyne S. , Günther C. , Abraham S. , Beissert S.
Published: May 2020

Die Sarkoidose ist eine Systemerkrankung, die vorwiegend die Lunge und auch die Haut betreffen kann. Charakteristisch sind erythematöse bis livide Plaques, die schmerzen können und bei Lokalisation an sichtbaren Körperbereichen zu Stigmatisierung mit Einschränkung der Lebensqualität führen können. Die Gabe von Steroiden ist die Standardtherapie, die jedoch nicht für alle Patienten ausreichend ist. Wir berichten über 2 Patienten mit kutaner Manifestation einer Sarkoidose, die erfolgreich mit TNF-alpha-Antagonisten behandelt wurden.