bluuebunny/crossref_metadata_2025 huggingface dataset:
Bio-ethanol production potential of Water Hyacinth (Eichhornia crassipes) as alternative energy feedstocks
Authors: Hirphaye Belete Yilma , Mezgebe Fitsum Hailemichael , Tura Alemu Mekonnen , Fanta Gada Muleta
Published: December 2022

Ecological disruptions and loss of productivity are foreseeable dangers facing Lake Abaya and the surrounding wetland. This in turn affected communities whose livelihood depends for fish and other Lake resources. The aim of the present study was to produce bioethanol from Water hyacinth (Eichhornia crassipes) as an alternative energy feedstock for a win-win eco-sanitation approach to halt ecological disruption. The Water hyacinth sample was collected from Lake Abaya in Arba Minch and pretreated to get rid of mud and dirty wash debris. DNS method was used for estimating Reducing sugars in the sample using DNS (3, 5- Dinitrosalicyclic acid) reagent. Bioethanol was obtained by fermentation of hydrolyzed substrates using Saccharomyces cerevisiae and was analyzed using qualitatively (Dichromate and FTIR methods) and quantitatively (Spectroscopic and Specific gravity methods). Our results indicated that Higher reducing sugar production efficiency (671.00 ± 3.00) was observed at 6% H2SO4 concentration on 10g biomass load. Lowest reducing sugar was recorded after hydrolysis of 5g biomass in 4% sulfuric acid. A promising alcoholic content (95 % v/v) and the existence of bioethanol by a combustion test shows Water hyacinth are also good sources of bioethanol. Generally, the FTIR spectroscopic investigation Conclude the product obtained from Water Hyacinth (Eichhornia crassipes) through acid hydrolysis, fermentation, and distillation was ethyl alcohol
An Improved Low-Computation Model Predictive Direct Power Control Strategy for Three-Level Four-Leg Active Power Filter
Authors: Wang Guifeng , Guo Jinxing , Liu Zhan
Published: December 2022

Model predictive direct power control (MPDPC) strategy offers numerous benefits over the traditional control strategies in active power filters (APF). However, the real-time execution duration (RTED) reduction of model predictive control in multilevel inverters is a big challenge. In this paper, an improved low-computation model predictive direct power control strategy for three-level four-leg APF (TL-FL-APF) is presented. First, based on generalized instantaneous reactive power theory, a new predictive power model for TL-FL-APF is established. Then, in order to reduce the RTED, classical multiple power predictions are converted into single voltage prediction through the principle of deadbeat control, and the optimized vector range is reduced from 81 to 4–18 by the method of spatial stratification using the γ-component of reference voltage vector. Finally, simulation and experimental results demonstrate that proposed low-computation MPDPC has excellent performance.
The mTOR/P70S6K signalling pathway regulates the effect of HIF-1α on LPS-induced barrier injury
Authors: Huang Zeyong , Teng Wenbin , Yao Liuxu , Wang Danyang , Hang Suqin , He Rui , Li Yuhong
Published: December 2022

Our previous studies have shown that hypoxia-inducible factor-1α (HIF-1α) has a protective effect on intestinal mucosal injury in septic rats, but the specific mechanism still needs to be clarified. In this study, we explored the protective effect of HIF-1α on intestinal mucosa in vitro and its molecular mechanism. Caco-2 cells were selected and experiment was divided into 2 parts. Part I: HIF-1α activator (DMOG) and inhibitor (BAY 87-2243) were used to treat LPS-stimulated Caco-2 cells respectively, to explore the effect of HIF-1α on LPS induced Caco-2 cell barrier injury; Part II: mTOR inhibitor (rapamycin), activator (MHY1485) combined with or without HIF-1α activator, inhibitor to treat LPS-stimulated Caco-2 cells respectively, and then the molecular mechanism of HIF-1α reducing LPS induced Caco-2 cell barrier damage was detected. The transmembrane resistance was measured by ERS-2 resistance meter, the permeation of fluorescein-labeled dextran (FD4) was measured by fluorescence method, and the protein levels of HIF-1α, Zona occludens 1 (ZO-1), occludin, claudin-1, p-mTOR and p-P70S6K were determined by Western blot. LPS induced Caco-2 cell injury, with decreased transepithelial electrical resistance (TEER) and increased FD-4 concentration. DMOG increased the TEER value, decreased the FD-4 concentration, and upregulated HIF-1α and tight junction (TJ) expression (P < 0.05) in Caco-2 cells, while BAY 87-2243 had the opposite effects. Rapamycin reduced the TEER, increased the FD-4 concentration, and downregulated the expression of p-mTOR, p-P70S6K, HIF-1α and TJs in Caco-2 cells (P < 0.05). MHY1487 increased the TEER, decreased the FD-4 concentration, and upregulated the expression levels of p-mTOR and p-P70S6K in Caco-2 cells (P < 0.05), while the expression levels of HIF-1α and TJs remained unchanged. Adding DMOG attenuated the effect caused by rapamycin, while adding BAY 87-2243 attenuated the effect caused by MHY1487. The results suggest that HIF-1α attenuate LPS-induced barrier injury in Caco-2 cells via regulation of the mTOR/P70S6K signalling pathway.
First Report of H5n3 Infection in a Captive Group of Emperor Tamarin (Saguinus Imperator)
Authors: Schlax Kévin , Fourçans Christophe , Niphuis Henk
Published: December 2022

Influenza A viruses cause respiratory infections that range from asymptomatic to deadly in humans. Non-human primates (NHPs) are susceptible to infection with a number of influenza A isolates, including viruses of the H3N2, H5N1 and H1N1 subtypes. A 9-year-old emperor tamarin (Saguinus imperator 0.1) presented acute respiratory distress and apathy. The animal died 24 hours after first clinical signs. A necropsy was performed and showed severe pulmonary congestion associated with thoracic and abdominal effusion. Bacterial and parasitological testing on different organ was negative. Unfortunately, no histological analysis was performed. However, a PCR analysis on lungs showed the presence of H5N3 virus. All the callitrichids that lived with this emperor tamarin (Saguinus imperator 0.1) : three emperor tamarins (Saguinus imperator 0.3) and three pygmy marmosets (Cebuella pygmaea 3.0) were sampled. Anti-Influenza A antibodies were found in all three emperor tamarins (Saguinus imperator 0.3) but not in the three pygmy marmosets (Cebuella pygmaea 3.0). All sera were negative for SARS-COV-2 analysis. The three emperor tamarins (Saguinus imperator 0.3) remained asymptomatic, and no treatment was given to them. All avian species in the zoo are vaccinated against influenza and no birds showed respiratory signs. An epidemiological survey is in progress to determine how the infection occurred. This condition has, to the best of our knowledge, not been reported in the literature.
Improvement of the electrical performance of Ag/MEH-PPV/SiNWs Schottky diode by the insertion of a thin layer of MEH-PPV polymer and study of the annealing effect
Authors: Jerbi L. , Rahmani M. , Ajlani H. , Guendouz M. , Lorrain N. , Oueslati M. , Meftah A.
Published: December 2022

Poly[2-methoxy-5-(2’-ethylhexyloxy)-1,4-phenylene vinylene] (MEH-PPV) thin layer was deposited on silicon nanowires (SiNWs) by electroless dipping method. SiNWs were obtained using Ag-assisted chemical etching process. Scanning Electron Microscopy (SEM) images reveal a vertical alignment of the SiNWs as well as the formation of MEH-PPV layer on their surfaces. The presence of MEH-PPV polymer on the SiNWs surface was confirmed by Energy-dispersive X-ray (EDX). Current-Voltage (I-V) measurements were performed for the electrical characterization of Ag/MEH-PPV/SiNWs diodes before and after annealing. The ideality factor (n), the barrier height (φb) and the series resistance (RS) are determined using the Cheung method. The diode parameters are strongly affected by the immersion duration in MEH-PPV solution as well as the annealing temperature. The rectification rate of the diodes was increased by MEH-PPV deposition. The annealing temperature has a great influence on the diode parameters by the thermal activation of carriers at Ag/MEH-PPV and MEH-PPV/SiNWs interfaces. I-V characteristics show an ohmic character for temperatures above 250° C. The electrical parameters such as equivalent carrier concentration (ND) and built-in voltage (Vb) and other values of φb are calculated from Capacitance-Voltage (C-V) measurements.
Actual anterior-posterior corneal radius ratio in eyes with prior myopic laser vision correction according to axial length
Authors: Yoon Seung Hee , Song Jae Ryong , Lee Seung Hyen , Eom Youngsub , Hyon Joon Young , Jeon Hyun Sun
Published: December 2022

We retrospectively evaluate the actual anterior-posterior (AP) corneal radius ratio in eyes with previous laser correction for myopia (M-LVC) according to axial length (AL) using biometry data exported from swept-source optical coherence tomography between January 2018 and October 2021 in a tertiary hospital (1,018 eyes with a history of M-LVC and 19,841 control eyes). The AP ratio was significantly higher in the LVC group than in the control group. Further, it was significantly positively correlated with AL in the LVC group. We also investigated the impact of the AP ratio and AL on the absolute prediction error (APE) in 39 eyes that underwent cataract surgery after M-LVC. The APE was significantly lower in the Barrett True-K with total keratometry (Barrett True-TK) than in the Haigis-L formula on eyes with AL above 26 mm. In eyes with AL of 26–28 mm, the percentage of prediction error within ± 1 D for Barrett True-TK and Barrett True-K was significantly higher than that for Haigis-L. In conclusion, in eyes with previous M-LVC, AP ratio increases with AL. The Barrett True-K or Barrett True-TK formulas are recommended rather than Haigis-L formula in M-LVC eyes longer than 26 mm.
Analysis and Design Optimization of Axial- Radial Flux Hybrid Excitation Permanent Magnet Eddy Current Coupling
Authors: Zhang Hongming , Liu Chengcheng , Zhang Shiwei , Wang Youhua , Lei Gang , Zhu Jianguo
Published: December 2022

This paper proposes an axial-radial flux hybrid excitation permanent magnet eddy current coupling (HE-PMEC), where the ferrite magnet is employed for producing the radial flux and the DC excitation current is adopted for producing the axial flux. Moreover, a shielding layer is developed to regulate the radial magnetic field. Its magnetic field distribution, electromagnetic performance, and temperature distribution are calculated based on the 3D finite element method (FEM). By adjusting the applied DC excitation current density and the insertion depth of the shielding layer, the variable current starting process, the variable current braking process, and the speed regulation characteristic of the proposed HE-PMEC are obtained. It can be seen that the starting process, braking process, and speed regulation ability of the HE-PMEC have been enhanced greatly. Furthermore, the copper ring shape of the HE-PMEC is optimized by using the proposed improved multilevel optimization method. It can be seen that the performance of the HE-PMEC can be improved by using the new optimized copper ring shape. Lastly, compared with the conventional PMECs, the proposed HE-PMEC has shown its superior electromagnetic performance.
Plant growth promoting microbes with antibiotic resistance; can that be used together
Authors: Lunavath Madhavi , Bhukya Bhima , Swamy Mahadeva
Published: December 2022

The antibiotic application reduces the microbial count of pathogenic microbes along with beneficial plant growth promoting bacteria (PGPB). This can be avoided if PGPB has antibiotic resistance. Thirty bacterial isolates were found from nutrient-rich alkaline soil, associated with phosphate and potassium solubilization and IAA production potential. Twelve isolates were shortlisted and the antibiotic sensitivity of the bacterial isolates was tested against eight antibiotics using the disc diffusion technique. Based on various physiological tests, compatibility and 16S rRNA sequence analysis, two PGPB Bacillus megaterium (M-08) and Bacillus aryabhattai (M-24) were identified. Both the isolates were positive for starch hydrolysis, catalase activity, acid and gas production, urease and gelatin liquefaction tests. Isolate (M-20) had the highest PSI of 6.0. M-26 had the highest KSI of 5.6. M-08 and M-24 were antagonistic against phytopathogenic R. solani. The present study indicated the presence of diverse P and K solubilising bacteria in the tomato rhizosphere, with IAA production potential and antibiotic resistance. These bacterial isolates can serve as potential plant growth promoters as they showed an increase in N, P and K uptake in the plant. The research tried to bring up a hypothesis of antibiotic selective plant growth promoters or biocontrol agents and their benefit in acclimatization and establishment in soil despite the microbicidal applications. This method can be used worldwide, to eradicate phytopathogens, while leaving the beneficial PGP microbes in rhizospheres.
A comparison of multi-criteria decision making techniques for prioritizing flood potential based on morphometric parameter analysis
Authors: Hajihasani Nadia , Ghadimi Mehrnoosh , Malekian Arash , Moghimi Ebrahim
Published: December 2022

One of the most important aspects of basin management is the prioritization of sub-basins. The flood potential of Kan sub-basins in Iran is prioritized in this study using morphometric parameters combined with model statistical correlation and multi-criteria decision-making systems. The Kan basin was studied using 17 morphometric parameters such as slope, elevation, curvature, ruggedness number, elongation coefficient, circularity coefficient, equivalent rectangle, drainage density, stream length, infiltration factor, time of concentration, duration-intensity of rainfall, land cover, land use, geology, bifurcation ratio, and length of overland flow. The relationship between parameters and weighting results revealed that climate and morphotopography (slope, elevation, curvature, and ruggedness number) were important factors in AHP flooding. Slope and time of concentration (0.11) duration-intensity of rainfall (0.12) have become one of the most critical factors in flooding in the ANP method. The Shannon entropy method identified stream length (0.15), elevation (0.11), and geology (0.11) as important flooding factors. Ranking in the AHP method revealed that the sub-basins of Imamzadeh Davood, Talun, and Doab had the highest score (0.74, 0.50, 0.41), and in the ANP method, the sub-basins of Imamzadeh Davood, Talun, and Sangan had the highest score (0.97, 0.51, 0.48). They were ranked first through third. Furthermore, Imamzadeh Davood, Talun, and Rendan rank first to third in Shannon entropy with points (0.97, 0.68, and 0.52). Other ranking methods, such as COPRAS, VIKOR, and TOPSIS, prioritized sub-basins. The TOPSIS method was deemed the best ranking method by Kendall and Spearman's correlation method. The results demonstrated that this model is highly accurate, and that morphometric sub-basins have a significant impact on flooding. Imamzadeh Davood and Sangan sub-basins are high-risk areas in this basin. There have been more floods in these areas. For validation, the HEC-HMS from the Natural Resources Organization's method was used. The HEC-HMS method yields results that are consistent with the Shannon entropy and ANP methods.
Rapidly growing sinus pericranii within a short period: a case report
Authors: Sun Yuchen , Wang Binglei , Wang huijuan
Published: December 2022

Sinus pericranii (SP) is a rare vascular malformation characterized by an abnormal communication between the intracranial and extracranial venous systems. [1]Sinus pericranii are most commonly seen in the distribution areas of the superior sagittal and transverse sinuses. [2] There are no uniform criteria for the etiology, pathogenesis, diagnostic criteria, treatment options, or prognosis of Sinus pericranii. [3] In this paper, we present the diagnosis and treatment of a child admitted to our neurosurgery department in 2019 with rapidly growing frontal Sinus pericranii, as well as the 3-year postoperative follow-up. Authors summarize the clinical presentation characteristics, diagnosis and treatment methods, and prognosis of this disease using relevant domestic and international literature to improve clinicians' understanding of this disease.
Segmentation Model Approaches using Cardiac Magnetic Resonance Images: A Review
Authors: khan Amjad , Iskander Dayang NurFatimah binti Awang Iskandar , chai Professor Dr. Wang Yin Chai , Lim Phei , ullah Faheem , ullah Javid , Ahmad Tariq
Published: December 2022

Automatic segmentation solution is the process of detecting and extracting information to simplify the representation of Cardiac Magnetic Resonance images (CMRI) of Left Ventricle (LV) contour. This segmented information, using CMR images, helps to reduce the segmentation error between expert and automatic segmented contours. The error represents missing region values calculated in percentages after segmenting a cardiac LV contour. This review paper will discuss the major three segmentation approaches, namely manual approach, semi-automatic, and fully automatic, along with the segmentation models, namely image-based models, region-based models, edge-based models, deformable-based models, active shape-based models (ASM), active contour-based models (ACM), level set-based models (LSM), and Variational LSM (VLSM). The review deeply explains the performance of segmentation models using different techniques. Furthermore, the review compares 122 studies on segmentation model approaches, i.e., 16 from 2004 to 2010, 40 from 2011 to 2016, and 63 from 2017 to 2021, and 3 other related studies were conducted LV contour segmentation, cardiac function, area-at-risk (AAR) identification, scar tissue classification, oedema tissue classification, and identification via presence, size, and location. Given the large number of articles on CMR-LV images that have been published, this review conducted a critical analysis and found a gap for researchers in the areas of LV localization, LV contour segmentation, cardiac function, and oedoema tissue classification and segmentation. Regarding critical analysis, this paper summrised a research gap and made useful suggestions for new CMR-LV researchers. Although a timely reviewed study can lead to cardiac segmentation challenges, which will be discussed in each review section.
Deep cervical abscesses in children: efficacy of the cefotaxime–rifampicin combination
Authors: BORY Céline , BORY Olivier , GUELFUCCI Bruno , NICOLLAS Richard , Moreddu Eric
Published: December 2022

Purpose
The objective is to determine whether a medical treatment, the combination of cefotaxime and rifampicin, is effective in avoiding surgery for managing deep cervical abscesses in children and to determine prognostic factors in the efficacy of this medical treatment.
Methods
This is a retrospective analysis of all patients under 18 presenting with para- or retro-pharyngeal abscess over the period 2010–2020 in two hospitals' pediatric otorhinolaryngology departments. One hundred six records were included. Multivariate analyses were performed to study the relationship between the prescription of the Cefotaxime-rifampicin protocol at the onset of the management and the use of surgery and to evaluate the prognostic factors of its efficacy.
Results
The 53 patients who received the cefotaxime-rifampicin protocol as first-line treatment (vs. 53 patients receiving a different protocol) required surgery less frequently: 7.5% versus 32.1%, validated by a Kaplan-Meier survival curve and a Cox model analysis adjusted for age and abscess size (Hazard Ratio = 0.21). This good outcome of the cefotaxime-rifampicin protocol was not demonstrated when it was instituted as a second-line treatment after the failure of a different protocol. An abscess larger than 32 mm at hospitalization was significantly associated with more frequent use of surgery in multivariate analysis adjusted for age and sex (Hazard Ratio = 8.5).
Conclusions
The cefotaxime-rifampicin protocol appears to be an effective first-line treatment in managing non-complicated deep cervical abscesses in children.
TMED9 is a Predictive Marker of Transition from Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma
Authors: Sariman Melda , Yaylaz Burcu Salman , Ayer Mesut , Ekmekci Sema Sirma , Suer Ilknur , Cefle Kıvanc , Palanduz Sukru , Ozturk Sukru , Nalcaci Meliha , Abaci Neslihan
Published: December 2022

Purpose: Plasma Cell Dyscrasias are a heterogeneous group of hematological diseases.
The candidate ten genes identified from our transcriptome data are highly valuable and specific.
Methods: We investigated the prognostic biomarker status of these genes in Plasma Cell Dyscrasias. Expression levels of ISG20, EEF2, TRIB1, RRBP1, TMED9, KDELR1, DNAJC1, DPP7, COPE and LMAN2 genes were measured via qRT-PCR from bone marrow samples of 38 Multiple Myeloma, 23 MGUS and 16 control groups.
Results: According to our results, in the Multiple Myeloma group, all genes were more highly expressed than control and MGUS groups (p<0.05) In addition, the striking correlation with anemia factors, calcium and Durie Salmon Staging indicates that DNAJC1 is an important risk factor for MM (p<0.05). TMED9 was another prominent gene that showed higher expression in Multiple Myeloma compared to other groups. Also, there was strong association between TMED9 gene expression and clinical parameters of urea, Ca, albumin, LDH, and IGA levels (p<0.05) Moreover, TMED9gene in our results sheds light on myeloma genesis.
Conclusion: This study contributed significantly to the search on prognostic biomarkers for Multiple Myeloma progression from MGUS and for starting early treatment in MGUS.
Soil salt distribution and cotton growth under mulched drip irrigation with soil moisture regulation in southern Xinjiang,China
Authors: Pingru He , Jingang Li , Shuang’en Yu , fucang Zhang , Tao Ma , Jihui Ding , Kaiwen Chen , Shuaishuai Guo , Suhang Peng
Published: December 2022

Aims
Water deficiency together with soil salinization have been seriously restricting the sustainable agricultural in southern Xinjiang, China for a long time. Optimal soil moisture regulation contributes to the amelioration of soil water and salinity for crops, which is favorable for plants production.
Methods
The field experiment with five soil water lower limit levels (85% FC (T1), 75% FC (T2), 65% FC (T3), 55% FC (T4) and 45% FC (T5), where FC is the field capacity) was conducted in southern Xinjiang to investigate the responses of soil water-salt dynamics and the cotton performance to soil moisture regulation strategies.
Results
The results indicated that the humid perimeter of soil water and leaching range of soil salt increased with the decrease of soil moisture lower limit. Though more soil salt was leached out for T5 treatment at flowering stage, soil salinity increased again at boll setting stage owing to the long irrigation interval. Soil salt accumulated in 0-100 cm after cotton harvest, and the accumulation amount followed T3 > T5 > T1 > T2 > T4. Moreover, with the decline of soil moisture lower limit, both the plant height and nitrogen uptake decreased significantly, while the shoot root ratio increased. Compared with the yield (7233.2 kg·hm-2) and water use efficiency (WUE, 1.27 kg·hm-2) of T1 treatment, the yield for T2 treatment only decreased by 1.21%, while the WUE increased by 10.24%.
Conclusion
The soil moisture lower limit of 75% FC was recommended for cotton cultivation in southern Xinjiang, China.
Towards a platform quantitative systems pharmacology (QSP) model for preclinical to clinical translation of antibody drug conjugates (ADCs)
Authors: Scheuher Bruna , Ghusinga Khem Raj , McGirr Kimiko , Nowak Maksymilian , Panday Sheetal , Apgar Joshua , Subramanian Kalyanasundaram , Betts Alison
Published: December 2022

A next generation multiscale quantitative systems pharmacology (QSP) model for antibody drug conjugates (ADCs) is presented, for preclinical to clinical translation of ADC efficacy. Two HER2 ADCs (trastuzumab-DM1 and trastuzumab-DXd) were used for model development, calibration, and validation. The model integrates drug specific experimental data including in vitro cellular disposition data, pharmacokinetic (PK) and tumor growth inhibition (TGI) data for T-DM1 and T-DXd, as well as system specific data such as properties of HER2, tumor growth rates, and volumes. The model incorporates mechanistic detail at the intracellular level, to account for different mechanisms of ADC processing and payload release. It describes the disposition of the ADC, antibody, and payload inside and outside of the tumor, including binding to off-tumor, on-target sinks. The resulting multiscale PK model predicts plasma and tumor concentrations of ADC and payload. Tumor payload concentrations predicted by the model were linked to a TGI model and used to describe responses following ADC administration to xenograft mice. The model was translated to humans and virtual clinical trial simulations were performed that successfully predicted progression free survival response for T-DM1 and T-DXd for the treatment of HER2+ metastatic breast cancer, including differential efficacy based upon HER2 expression status. In conclusion, the presented model is a step toward a platform QSP model and strategy for ADCs, integrating multiple types of data and knowledge to predict ADC efficacy. The model has potential application to facilitate ADC design, lead candidate selection, and clinical dosing schedule optimization.
Immune-related adverse events after immune checkpoint inhibitor exposure in adult cancer patients with pre-existing autoimmune diseases
Authors: Machado Antonio Pizuorno , Shatila Malek , Liu Cynthia , Wang Jianbo , Altan Mehmet , Zhang Hao Chi , Thomas Anusha , Wang Yinghong
Published: December 2022

Purpose
Immune checkpoint inhibitor (ICI) therapy can predispose patients to immune-related adverse events (irAEs) and autoimmune disease (AD) flare-ups, but the characteristics of irAEs among patients with pre-existing ADs are largely unknown. We conducted this study to determine the clinical courses, irAEs, AD flares, treatment, and outcomes of patients with AD on ICIs.
Methods
This was a retrospective study of adult cancer patients at a large cancer center who were diagnosed with ADs before undergoing ICI therapy. Patients’ clinical courses, complications, treatments, and outcomes related to both ADs flares and irAEs were collected and analyzed.
Results
The study included 197 patients. Most (55.4%) were women. Melanoma comprised the highest proportion (28.4%) of malignancies, and most (83.8%) patients received PD-1/PD-L1 inhibitors. Fifty (25.3%) patients developed a new irAE after starting ICI therapy, while 29 (14.7%) patients had an AD flare-up. Patients with inflammatory bowel disease had the highest incidence of AD flare-ups (31.7%), while patients with Hashimoto hypothyroidism had the highest incidence of new irAEs (39.2%). Patients with inflammatory bowel disease had more severe adverse events. In our cohort, patients with a new diagnosis of irAE were treated with immunosuppressive therapy. AD flares were managed similarly. With regard to irAE manifestations, the most common presentations were colitis (24 [12.1%] patients), hepatic transaminase elevations (8 [4%] patients), and pneumonitis (7 [3.5%] patients).
Conclusion
Our findings suggest that patients with gastrointestinal and rheumatologic ADs had a higher incidence of AD flare-ups, while patients with Hashimoto hypothyroidism and neurologic ADs had a higher incidence of new irAEs. Patients with prior ADs experiencing flare-ups or new irAEs after ICI therapy tend to require aggressive immunosuppressive treatment. Thorough evaluation of baseline disease status, appropriate medical management before ICI therapy, and early recognition of inflammatory exacerbation may help ensure long-term success in treating and improving outcomes in these patients.
Acquisition of tacit knowledge to enhance economic competitiveness: An empirical validation by Cosine distance
Authors: Aubin Amanzou Nogbou Andetchi
Published: December 2022

Knowledge is the core of economic development because it has an increasing return to scale. It has two forms: explicit and tacit. It is more important to collect tacit knowledge because it would lead to the creation of new innovations. Unfortunately, the acquisition of tacit knowledge is costly because it is difficult to collect using investments in research and development and/or investments in education. Economists advocated three theories for ease of acquisition of tacit knowledge: the theory of learning regions, the theory of the communities of practices, and the theory of knowledge enablers. We did an empirical analysis of these theories by using cosine distance. The data have been collected during the study of the production of a local food originating from Côte d’Ivoire called “ Attiéké”. The results showed that the knowledge is different from one region to another and negatively correlates with geographical distance. The community of practice goes beyond nativity and is linked to training. The knowledge enabler is less efficient when he is far from the geographical area of original tacit knowledge. So, we recommend the Cosine Distance as a tool for decision-making in knowledge economics because it allows the arrangement of activities to collect tacit knowledge more efficiently.
Explaining biological differences between men and women by gendered mechanisms
Authors: Colineaux Hélène , Neufcourt Lola , Delpierre Cyrille , Kelly-Irving Michelle , Lepage Benoit
Published: December 2022

Background. The principal aim of this study was to explore if biological differences between men and women can be explained by gendered mechanisms.
Methods. We used data from the 1958 National Child Development Study, including all the living subjects of the cohort at the outcome collection wave (44-45 years). We explored several biomarkers as outcomes: systolic blood pressure, triglycerides, LDL cholesterol, HbA1c, CRP, and cortisol. Three conceptualizations of gender have been used to define methodological strategies: (a) Gender as an individual characteristic; (b) Gender as an effect of birth sex on socio-behavioural characteristics; (c) Gender as an interaction between birth sex and the social environment, here the early-life social environment. We estimated the total effect of sex and the proportion of total effect of birth sex eliminated by gender, measured by 3 different ways according to these 3 concepts, using g-computation.
Results. The average level of each biomarker was significantly different according to birth sex, higher in men for cardiometabolic biomarkers and higher in women for inflammatory and neuroendocrine biomarkers. The sizes of the differences were always smaller than one standard deviation but were larger than differences due to early-life deprivation, except for CRP. We observed gender mechanisms underlying these differences between men and women, even if the mediation effects were rarely statistically significant. These mechanisms were of three kinds: (1) mediation by socio-behavioural characteristics; (2) attenuation by gendered mechanisms; (3) interaction with early social environment. Indeed, we observed that being born into a deprived rather than non-deprived family increased metabolic and inflammatory biomarkers levels more strongly in females than in males.
Conclusions. The biological differences between men and women seem to not be purely explained by biological mechanisms. The exploration of gender mechanisms opens new perspectives, in terms of methodology, understanding and potential applications.
Association of quantitative analysis of intratumoral reduced E-cadherin expression with lymph node metastasis and prognosis in patients with breast cancer
Authors: Meng Xiangyue , Morita Michi , Kuba Sayaka , Hayashi Hiroko , Otsubo Ryota , Matsumoto Megumi , Yamanouchi Kosho , Kobayashi Kazuma , Soyama Akihiko , Hidaka Masaaki , Kanetaka Kengo , Nagayasu Takeshi , Eguchi Susumu
Published: December 2022

Loss of E-cadherin expression is a poor prognostic factor in patients with breast cancer. Breast cancer cells co-cultured with adipocytes reportedly promote E-cadherin attenuation and tumor progression. The current study aimed to investigate the association of reduced E-cadherin expression with adipose tissue invasion (ATI) and prognosis in breast cancer. Surgical specimens were collected from 188 women with invasive ductal carcinoma of the breast who had undergone surgery without neoadjuvant treatment. We compared E-cadherin expression in ATI and invasive front (IF) using immunohistochemistry with ImageJ. Reduced E-cadherin expression was detected not only in the ATI area but also in IF, and the degree of reduced E-cadherin expression was positively correlated with both areas. E-cadherin expression was reduced in patients with lymph node metastasis compared to those without, and reduced E-cadherin expression was an independent factor associated with lymph node metastasis, and poor recurrence-free survival than those without. We concluded that E-cadherin expression is reduced not only in the ATI area, but also at the invasive front of the tumor. Reduced E-cadherin expression is a clear prognostic factor for breast cancer. Hence, future research is warranted for establishing an objective and quantitative E-cadherin staining assay that will allow clinical use of E-cadherin as a prognostic factor.
Theory of sigma bond resonance in flat boron materials
Authors: Qiu Lu , Zhang Xiuyun , Kong Xiao , Mitchell Izaac , Yan Tianying , Kim Sung Youb , Yakobson Boris , Ding Feng
Published: December 2022

In chemistry, theory of aromaticity and π bond resonance plays a central role in intuitively understanding the stability and properties of organic molecules. Here we present an analogue theory for σ bond resonance in flat boron materials, which allows us to determine the distribution of two-center two-electron and three-center two-electron bonds without quantum calculations. Based on this theory, three rules are proposed to draw the Kekulé-like bonding configurations for flat boron materials and to explore their properties intuitively. As an application of this theory, the mystery of why neutral borophene with ~ 1/9 hole has the highest stability and the effect of charge doping on borophene’s optimal hole concentration are understood with the assumption of σ and π orbital occupation balance. Like the aromaticity theory for carbon materials, this theory greatly deepens our understanding on boron materials and paves the way for the rational design of various boron-based materials.
Den Lücken in der zu Geschichte geronnenen Vergangenheit nachspüren
Authors: Gimplinger Martina
Published: December 2022

When Even The

Neunzig Minuten lang liegt der erratische, metallene Gegenstand starr und still vor uns auf der Bühne. Als wäre er dem Ort, dem er einmal angehörte, und der Verwendung, die man ihm einmal zugeschrieben hatte, entrissen worden. Seine feste, stählerne Materialität lässt ihn viele Jahre überdauern, selbst in dem jetzt abgenutzten, verbogenen, verrosteten Zustand. Die Wölbung, die sein fester Metallkörper aufweist, verleiht ihm etwas Bewegliches. Sie scheint von einer vergangenen Dynamik zu zeugen, die im Widerspruch zur offensichtlichen Schwere und Unbeweglichkeit des Materials steht. [...]
Sammeln ohne Sammlung, Forschung ohne Universität
Authors: Piech Janina
Published: December 2022

Widmen sich Forscher*innen, die außerhalb des akademischen Zentrums agieren, vermehrt auch peripheren Forschungsinhalten? Welche innovativen Methoden sind signifikant für diese Wissenschaftler*innen und in welchem Verhältnis stehen ihre Forschungsergebnisse zum universitären Kanon? Diesen Fragen gehe ich anhand der Forscher- und Sammlerbiografie des Privatgelehrten Heinrich Hubert Houben in meinem Dissertationsprojekt nach und analysiere diesen kaum definierten Gelehrtentypus, der sich häufig in außeruniversitären Strukturen wiederfindet, aber selten in den wissenschafts- und fachhistorischen Fokus rückt. Der vorliegende Beitrag soll einen Einblick in den Facettenreichtum dieser Untersuchung geben und zeigen, welche Diskurse sich daraus für die zeitgenössische Fachgeschichte ergeben.
Der Hamiltonkomplex
Authors: Kallenbach Laura
Published: December 2022

Wie arbeiten Menschen am Theater und das Theater an ihnen? Wer macht Theater? Als was begreifen wir theatrale Räume ästhetisch, gesellschaftlich, (macht-)politisch? Solche strukturellen Fragen an die Institution Theater rücken auf kulturpolitischer, künstlerischer und theaterwissenschaftlicher Ebene in jüngster Zeit dringlicher in den Fokus. Theaterpädagogischer Arbeit – d.h. künstlerischer Arbeit mit explizit nicht-professionellen Akteur*innen – sind diese Fragen elementar eingeschrieben und sie zeigen sich dabei in der Praxis wie auch Untersuchung dieser Arbeit zugleich als ästhetische Fragen.
WENN DIE KÖRPER POSITION BEZIEHEN
Authors: Trachsel Ekaterina
Published: December 2022

Um scheinbar schwerelos über den Boden zu gleiten, werden die Füße in Spitzenschuhe gezwängt. Es wird die perfekte Frisur geknotet, um an dieser hoch zu den Traversen gezogen zu werden. Um engelsgleich über der Bühne aufgehängt zu werden, wird der Rücken mit Fleischerhaken penetriert. Und damit die 78-jährige ehemalige Primaballerina Beatrice Cordua mit ihren Ballett-Schülerinnen zufrieden ist, müssen auch mal die Beine gespreizt werden. Wir haben es in TANZ von Florentina Holzinger mit einer dramaturgischen Ordnung zu tun, welche Wahrnehmungsgewohnheiten in Unordnung bringt, indem die Körper „Position beziehen“. [...]
Zur Resistenz von Theater im Medienzeitalter
Authors: Kotte Andreas
Published: December 2022

Worauf gründet die Gelassenheit von Theater angesichts von Digitalisierung und Medienpräsenz? Wie lässt sie sich erforschen? Danach fragt dieses Resümee eines theaterwissenschaftlichen Konzepts.

Nach zwei Jahren Pandemie und unzähligen beherzten Versuchen, Theatersituationen zu schaffen, fast oder ganz ohne ein Publikum, das sich mit den Agierenden zur gleichen Zeit am gleichen Ort trifft, wird nun die Aufarbeitung dessen erfolgen, was trotzdem gut funktioniert hat. Einige der medialen Versuche werden weitere anregen. Sie werden das riesige Spektrum von Theater erneut als „glutton“ ausweisen, als Vielfraß, der sich mit stoischer Ruhe auch Mediales einverleibt. Die hauptsächliche Reaktion wird aber ein Aufatmen sein, endlich wieder das, was man die Kopräsenz von Agierenden und Schauenden genannt hat, sinnlich auskosten zukönnen. In der gegenwärtigen liminalen Phase, die als Rückkehr zu alter Normalität, aber auch als ein Neubeginn gedeutet werden kann, erscheint es angemessen, über das Wechselverhältnis von Theater und elektronischen Medien noch einmal nachzudenken.
Analyzing Grammatical and Lexical Cohesion in A Legendary Short Story
Authors: Noprival Noprival , Alfian Alfian , Soma Robi
Published: December 2022

Analyzing Grammatical and Lexical Cohesion in A Legendary Short Story Noprival Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi, Jambi, Indonesiae-mail: noprival@gmail.com (corresponding author) Alfian Universitas Islam Negeri Sulthan Thaha Saifuddin Jambi, Jambi, Indonesiae-mail: alfian@uinjambi.ac.id Robi SomaUniversitas Jambi, Jambi, Indonesiae-mail: robisoma858@unja.ac.id Abstract:Despite the existence of many studies on cohesion in discourse, little scholarly work reports grammatical and lexical cohesion in a short story. To fill this gap, the present study investigates these two aspects of cohesion in a legendary short story entitled “After Twenty Years.” Halliday and Hasan’s (1976) theoretical framework of cohesion was used to guide the current study. We applied textual analysis as the appropriate approach to find out grammatical and lexical cohesion within the forms of text. The findings in the grammatical cohesions showed that reference had the highest frequency of the total cohesive devices. Also, under grammatical cohesion, conjunctions are found to exist. However, other aspects were not found within this short story, including substitution and ellipsis. On the other hand, repetition was dominantly used lexically among other aspects of lexical cohesion and sequentially followed by repetitions, hyponyms, synonyms, and antonyms. Only one aspect of lexical cohesion, the meronym, was not found.  The overall results of the research indicated that the short story was a coherent discourse because both grammatical and lexical cohesion exist properly.
System and Structure of English Classroom Discourse at Junior High School in Medan
Authors: Mutia Maulidina , Lubis Masdiana , Nurlela Nurlela
Published: December 2022

This study aims to investigate the system and structure of English classroom interaction at Medan's Jabal Rahmah Mulia Boarding School. The records of a discussion in communication a video recording by Zoom Meeting among understudies and an English educator are viewed as information to be concentrated on utilizing a talk examination approach in light of Martin's Conversation Analysis (CA) model inside Halliday's Systemic Functional Linguistics structure (SFL). The foundation of the framework and construction of the English study hall connection are the challenges to be addressed. The examination saw movement types, temperament types, and the discourse capability of different provisions. The discoveries show that understudies act as initiators, while English educators work as allies, with optional knower (k2k1) moving sort for the most part; the communication is one of data exchange instead of labor and products, as conversationalists favor decisive and utilize basic sparingly. As per the discoveries, Question (Q) appears to generally satisfy the data given. Inquisitive asking is most ordinarily used to exhibit that a design's relational significance doesn't be guaranteed to compare to its lexico-sentence structure. This examination likewise shows how a study hall conversation happens in a characteristic set of mindset and discourse capability. It likewise demonstrates that understudies are on the requesting end of the scale, bringing about an absence of criticism in the communication.
Revisiting the motives for hydroinformatics
Authors: Jonoski A.
Published: December 2022

Since Mike Abbott established hydroinformatics about 30 years ago, the field has been characterized by tremendous growth in both research and practice. With its natural dependence on developments in information and communication technologies, the expansion and diversity of hydroinformatics concepts and applications have hardly been surprising. Such developments have brought some issues of concern within the hydroinformatics community, mainly associated with apparent loss of some foundational principles. This chapter attempts to clarify the current situation by revisiting the main motivations for hydroinformatics, as originally proposed and later developed by Abbott. It also re-introduces and re-interprets the main aspects of the field, with the hope that such a re-interpretation will be useful for the future growth and development of the subject. Hydroinformatics originated as an engineering discipline, specifically linked to hydraulic engineering and to the development and use of numerical models from within the field of computational hydraulics. This initiated the central idea that modelling in hydroinformatics is motivated by applications in the real world. The union of fourth-generation modelling systems with artificial intelligence, was originally regarded as being the essence of hydroinformatics. The initial emphasis of the subject was on developing models of our natural aquatic environment and man-made water infrastructure that were more reliable, leading to improved support for decision making. As a consequence, improving model generation and application for decision support became central, and the field of hydroinformatics was established as a technology for enabling transparent knowledge creation, mobilization and sharing among different stakeholders participating in water- and environmental decision making. Aiming at transforming decision-making processes (and not only supporting existing ones), hydroinformatics identified the Internet as the key platform for introducing environments that would enable the conjunctive use of different ‘knowledges’ (scientific, as well as social/cultural/narrative knowledge). These last aspects are ongoing motivations for hydroinformatics to continue its development as a technology with the responsibilities of caring for the aquatic environment and improving human well-being.
Application of isotopic tools to understand the hydrological processes and groundwater dynamics of Mianwali area-Punjab, Pakistan
Authors: Ghaffar Abdul , Iqbal Naveed
Published: December 2022

The study was conducted to investigate the hydrological system of ‘Mianwali’ area, which comprises an alluvium aquifer. Groundwater dynamics including groundwater direction, velocity and recharge mechanism were investigated to assess the groundwater sources conservation in the area. Hydrological samples were collected and analyzed for stable isotopes (18O and 2H); radioisotopes (3H), chloroflourocarbons (CFCs) and groundwater real and filtration velocities measured to understand the groundwater dynamics. Isotopic data suggested a variant recharge mechanism due to localize impacts of canals, lake and river. Groundwater residence time, using Tracer Lump Parameter Model (LPM), and CFCs data suggest a very young water in the range of 14–59 years old. The real and filtration velocities of groundwater found to be 22.2 cm/day and 10.94 cm/day, respectively, in south-west direction and in-situ effective porosity of the aquifer was 49.3%. The hydraulic conductivity of the aquifer was estimated using grain size analysis that varies from 48 to 278 m/day with average value of 139 m/day.
Some peculiarities of application of the exclusive right to inventions, utility models and industrial designs
Authors: Zakharova Karina Viktorovna
Published: December 2022

The article aims to investigate the institution of the exercise of the exclusive right to intellectual property such as inventions, utility models and industrial designs. The article reflects some problematic aspects of theoretical and practical nature that arise in the process of implementation of the exclusive right to patent rights by patent holders.
Ineficácia das políticas públicas de assistência farmacêutica no Brasil, a judicialização da saúde com política pública
Authors: Menezes Anderson de Alencar , Silva Antonio Tancredo Pinheiro da , Silva Clarissa Maria Cavalcante , Ribeiro Edmilson Pinto , Rocha Tiago Mesquita Duarte da
Published: December 2022

O presente trabalho busca levar ao conhecimento do leitor informações acerca de políticas públicas, nos atemos as que estão voltadas a saúde, trazendo uma discussão sobre a ineficácia da assistência farmacêutica no Brasil/Alagoas/Maceió. Nesse contexto traremos uma visão sobre a atuação das Defensorias Públicas e a judicialização da saúde como forma de garantir o acesso à saúde aqueles que mais necessitam dessa Política Pública. Para que tais objetivos sejam alcançados, faremos uma pesquisa de dados em jornais acadêmicos, revistas, sites oficiais que trazem dados sobre essa demanda e as relações com ajuizamento de ações. Para ilustrar a temática buscaremos nas ideias de Habermas um contexto amplo que nos dê subsídios para afirmar que tal Política Pública visa oferecer aqueles mais necessitados uma contribuição de cunho social e que está fundamenta-se nos direitos humanos fundamentais e devem serem assegurados pelo Estado, como por exemplos direitos fundamentais a saúde. Desse modo, levando em consideração a teoria adotada pelo filósofo alemão, Jürgen Habermas em seu livro Teoria do agir comunicativo, é preciso aumentar a desburocratização para viabilizar os direitos assegurados pelo cidadão, assim esses emergem com maior nitidez e transparência. Nesse contexto o paradoxo de integração e desintegração social é importante, tendo em vista que o poder é realçado perante a espera de amparo do estado pelas pessoas necessitadas nas quais são ultrapassadas por influentes sociais.