bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical Treatment of Pulmonary Metastases of Colorectal Cancer: The Impact of Isolated Lung Chemoperfusion on Pulmonary Recurrence-Free Survival
Authors: Левченко Евгений Владимирович , Клочков Михаил Владимирович , Михнин Александр Евгеньевич , Сенчик Константин Юрьевич , Мамонтов Олег Юрьевич , Ергнян Степан Мкртычевич , Лопушанская Ольга Олеговна , Левченко Никита Евгеньевич , Юрин Роман Иванович , Слугин Евгений Николаевич , Хандогин Николай Владимирович , Шабинская Виктория Игоревна
Published: September 2024

Введение. Несмотря на то, что легочная метастазэктомия не входит в стандарты лечения колоректального рака, эта операция широко применяется на практике. Вопрос об её реальной эффективности на сегодняшний день остается открытым. Не изучено влияние изолированной химиоперфузии легких на результаты метастазэктомии при легочных метастазах колоректального рака.
Цель. Выявление подгруппы (кластеры) пациентов с легочными метастазами колоректального рака, для которых легочная метастазэктомия с изолированной химиоперфузией легких повышает безрецидивную выживаемость в легком, по сравнению со стандартной метастазэктомией.
Материалы и методы. Материалом исследования послужила последовательная серия 152 наблюдений за пациентами, перенесшими хирургическое удаление легочных метастазов колоректального рака с 2016 по 2024 гг. в торакальном отделении ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России. Общими критериями отбора для легочной метастазэктомии были излеченная первичная опухоль, излеченные вторичные очаги, отсутствие локорегионарных рецидивов и функциональная резектабельность пациентов. Критериями отбора для метастазэктомии с изолированной химиоперфузией легких были билатеральные, множественные и рецидивные легочные метастазы. Практически все пациенты до метастазэктомии получали химиотерапию в лечебном или адъювантном режиме. Открытые метастазэктомии с изолированной химиоперфузией легких были выполнены 66 (43,4 %) пациентам; стандартные видеоассистированные и открытые метастазэктомии — 86 (56, 6%) пациентам.
Результаты. У больных, отобранных на метастазэктомию с изолированной химиоперфузией легких, медиана безрецидивной выживаемости составила 18,8 мес. После стандартных метастазэктомий медиана безрецидивной легочной выживаемости была 21,0 мес. Применение химиоперфузии легких не позволило в полной мере компенсировать влияние неблагоприятных факторов, лежавших в основе отбора.
Заключение. При хирургическом лечении легочных метастазов колоректального рака применение изолированной химиоперфузии легких увеличивает легочную безрецидивную выживаемость в кластере женщин моложе 71 года с билатеральными и множественными легочными очагами, возникшими ранее 12 мес. после удаления первичной опухоли. В нашем исследовании таких наблюдений было 20 из 66 (30,3 ± 5,7 %). В общей когорте пациентов с легочными метастазами колоректального рака, получавших современное лекарственное лечение, изолированная химиоперфузия легких с цисплатином как метод одномоментной и кратковременной регионарной химиотерапии существенно не влияла на лёгочную безрецидивную выживаемость.
Surgical Treatment of Pulmonary Metastases of Colorectal Cancer: The Impact of Isolated Lung Chemoperfusion on Overall Survival
Authors: Левченко Евгений Владимирович , Клочков Михаил Владимирович , Михнин Александр Евгеньевич , Сенчик Константин Юрьевич , Мамонтов Олег Юрьевич , Ергнян Степан Мкртычевич , Лопушанская Ольга Олеговна , Левченко Никита Евгеньевич , Юрин Роман Иванович , Слугин Евгений Николаевич , Хандогин Николай Владимирович , Шабинская Виктория Игоревна , Змитриченко Юлия Геннадьевна
Published: September 2024

Введение. Легочная метастазэктомия не входит в стандарты лечения колоректального рака, однако эта операция широко применяется на практике, несмотря на то, что вопрос о её реальной эффективности остается открытым. Также не исследовано влияние изолированной химиоперфузии легких при легочных метастазах колоректального рака на результаты метастазэктомии.
Цель. Целью исследования являлось выявление подгруппы (кластера) пациентов с легочными метастазами колоректального рака, в которой легочная метастазэктомия с изолированной химиоперфузией легких улучшает наблюдаемую (общую) выживаемость, по сравнению со стандартной метастазэктомией.
Материалы и методы. Материалом исследования послужили данные о 133 больных с метастазами колоректального рака, перенесших легочные метастазэктомии с 2016 по 2023 гг. в торакальном отделении ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России. Открытые метастазэктомии с изолированной химиоперфузией легких были выполнены 59 (44,4 %) пациентам. Стандартные видеоассистированные и открытые метастазэктомии были выполнены 74 (55,6 %) больным. Общими критериями отбора для легочной метастазэктомии были: излеченность первичной опухоли и вторичных поражений печени, отсутствие локорегионарных рецидивов и функциональная резектабельность пациентов. Показанием к изолированной химиоперфузии легких являлись резектабельные легочные рецидивы, множественное и билатеральное поражение легких.
Результаты. Пятилетняя наблюдаемая выживаемость в общей группе пациентов (133) равнялась 48,2 ± 6,4 % с медианой 58,5 % мес. У пациентов, отобранных из общего потока на метастазэктомию с изолированной химиоперфузией легких, медиана наблюдаемой выживаемости составила 54,1 мес. После стандартных метастазэктомий медиана наблюдаемой выживаемости равнялась 60,6 мес. Применение изолированной химиоперфузии легких с цисплатином не компенсировало влияние неблагоприятных факторов, лежащих в основе отбора. Идентифицирован кластер пациентов, у которых наблюдалось повышение наблюдаемой выживаемости после ИХПЛ.
Заключение. При колоректальном раке метастазэктомия с изолированной химиоперфузией легких увеличивает наблюдаемую выживаемость, по сравнению со стандартной метастазэктомией у пациентов моложе 56 лет без поражения печени при числе легочных метастазов менее 6. В нашем исследовании таких наблюдений было 15 из 59 (25,4 ± 5,7 %). В общей когорте пациентов с метастазами колоректального рака в легких, получающих современное медикаментозное лечение, изолированная химиоперфузия легких как метод однократной и кратковременной регионарной химиотерапии существенно не влиял на общую выживаемость.
Comparison of Stem Cell Mobilization Efficacy with Intermediate Dose Cytarabine Versus Cyclophosphamide or Plerixafor in Poor Mobilizers
Authors: Елхова Светлана Сергеевна , Филатова Лариса Валентиновна , Зюзгин Илья Сергеевич , Волчёнков Станислав Андреевич , Ишматова Ирина Валерьевна , Зверькова Анна Андреевна , Никулина Юлия Александровна , Крамынин Леонид Александрович , Добровольская Евгения Викторовна , Семиглазова Татьяна Юрьевна
Published: September 2024

Введение. Недостаточный сбор стволовых кроветворных клеток крови является важной проблемой при планировании аутологичной трансплантации костного мозга. Для пациентов с факторами риска неудовлетворительной мобилизации оптимального режима ее проведения до сих пор не существует. По результатам последних исследований мобилизация цитарабином в средних дозах демонстрирует свою высокую эффективность.
Цель. Сравнить эффективность мобилизации цитарабином в средних дозах в сочетании с гранулоцитарным колониестимулирующим фактором (Г-КСФ) с существующими режимами мобилизации: циклофосфамидом + Г-КСФ и комбинации плериксафора + Г-КСФ.
Материалы и методы. Ретроспективно проанализированы результаты мобилизации 85 пациентов с факторами риска неудовлетворительной мобилизации, 28 из которых получили цитарабин + Г-КСФ, 28 — циклофосфамид + Г-КСФ и 29 — плериксафор + Г-КСФ.
Результаты. Медиана количества собранных CD34+ клеток составила 10,2 млн CD34+ клеток/кг в группе цитарабина, 7,2 млн/кг — в CD34+ клеток/кг группе циклофосфамида и 2,5 млн CD34+ клеток/кг в группе плериксафора (р < 0,0001). Медиана количества циркулирующих в периферической крови CD34+ клеток составила 153/мл в группе цитарабина, 129 клеток/мл в группе циклофосфамида и 33 клеток/мл в группе плериксафора (р = 0,005).
Выводы. Проведенное исследование демонстрирует высокую эффективность цитарабина в средних дозах как мобилизационного курса. Этот метод может стать режимом выбора для пациентов с факторами риска неудовлетворительной мобилизации.
Impact of Cancer Stem Cell Markers Expression in Patients with Glioblastoma on Treatment Outcomes
Authors: Гуляев Дмитрий Александрович , Чижова Ксения Александровна , Сулин Константин Андреевич , Курносов Иван Александрович , Митрофанова Любовь Борисовна , Самочерных Никита Константинович , Чиркин Владислав Юрьевич
Published: September 2024

Введение. Глиобластома представляет собой наиболее злокачественную первичную опухоль головного мозга. Прогрессия и рецидив данного новообразования остаются неизбежными событиями. Считается, что устойчивости к лечению глиобластомы способствуют раковые стволовые клетки (РСК). В настоящее время отсутствует идеальный набор маркеров для точной характеристики РСК, позволяющий спрогнозировать течение заболевания или ответ на лечение. Цель. Изучение отдаленных результатов лечения больных с глиобластомами на основании анализа наличия и степени экспрессии маркеров РСК.
Материалы и методы. У 16 больных с верифицированными глиобластомами Grade 4 (IDH-wildtype) было выполнено тотальное микрохирургическое удаление опухоли. Катамнестическое наблюдение проводилось с марта 2019 по октябрь 2023 гг. Средняя общая выживаемость составила 17,0 ± 10,7 мес. (Q1-11,3, Q3-22,8), минимально — 4,1 мес., максимально — 36,8 мес. Был выполнен корреляционный анализ взаимосвязи общей выживаемости и маркеров раковых стволовых клеток глиобластомы, таких как Nanog, Nestin, CD133, SOX2, FOXM1 и CD38 %. Статистический анализ проводился с использованием программы StatTech v. 3.1.10 (разработчик — ООО «Статтех», Россия).
Результаты. По результатам корреляционного анализа между экспрессией nanog и общей выживаемостью связь отсутствовала. Слабой тесноты обратная связь была установлена при оценке экспрессии nestin, CD133, CD38 % и общей выживаемости. При оценке связи SOX2 и общей выживаемости была установлена слабой тесноты прямая связь. При оценке FOXM1 и общей выживаемости была установлена умеренной тесноты прямая связь. С помощью метода множественной линейной регрессии была выполнена оценка зависимости общей выживаемости от совокупности маркеров РСК. Полученная регрессионная модель характеризуется коэффициентом корреляции rxy = 0,534, что соответствует заметной связи по шкале Чеддока. Модель не была статистически значимой (p = 0,725). Таким образом, маркеры раковых стволовых клеток, изученные нами, не являются предикторами для модели прогнозирования общей выживаемости, статистически значимые связи установлены не были.
Заключение. Исследование дополнительных маркеров раковых стволовых клеток глиобластомы в целях прогнозирования результатов лечения в клинической практике на настоящий момент нецелесообразно и не влияет на тактику. На сегодня основным доказанным подходом к курации пациентов с глиобластомами является локальный контроль.
Milestones in the History of the Establishment of the Oncological Service of the Russian Federation: Analysis of the Prerequisites, Significance and Results of the Implementation of the Historic Decree of 1945. Review of archival materials on the eve of the 80th anniversary of the Decree of the Council of People's Commissars of the USSR of 30.04.1945 No. 935 «On Measures to Improve the Cancer Care of the Population»
Authors: Аксенова Ирина Алексеевна , Попова Надежда Владимировна , Старинский Валерий Владимирович , Ходакова Ольга Владимировна
Published: September 2024

В рамках изучения истоков организации доступности квалифицированной медицинской помощи пациентам с онкологическими заболеваниями было изучено постановление Совета Народных Комиссаров СССР от 30.04.1945 № 935 «О мероприятиях по улучшению онкологической помощи населению» (далее — Постановление СНК), которое было нацелено на выстраивание в СССР цельной многоуровневой системы оказания медицинской помощи и вместе с этим на организацию отдельных звеньев онкологической службы. В силу сложившейся к концу Великой Отечественной войны (далее — ВОВ) необходимости организации полноценной системы оказания специализированной медицинской помощи пациентам с онкологическими заболеваниями, с одной стороны, и, с другой стороны, наличия неблагоприятных условий послевоенного периода, разрушенной на большой территории инфраструктуры, дефицита медицинских кадров, реализация поставленных целей сопровождалась большим количеством сложностей. Усилия, вложенные в реализацию Постановления СНК, вовлеченность в работу различных ведомств воистину представляют собой подвиг советского народа. Структурные преобразования онкологической службы, утвержденные Постановлением СНК, сформировали основу системы оказания медицинской помощи пациентам с онкологическими заболеваниями, которая по сей день успешно функционирует и непрерывно совершенствуется.
Development of Palliative Care in St. Petersburg. Dedicated to A.V. Gnezdilov
Authors: Вагайцева Маргарита Валерьевна , Рязанкина Алла Алексеевна , Джалилова Анастасия Андреевна , Волков Николай Олегович , Сенчук Руслана Богдановна , Семиглазова Татьяна Юрьевна , Беляев Алексей Михайлович
Published: September 2024

Сегодня во всем мире наблюдается рост показателя распространённости злокачественных новообразований, который обусловлен не только увеличением заболеваемости, но и такими факторами, как выявляемость заболевания и повышение длительности жизни пациентов на этапе ремиссии. При этом также выявляется рост показателей инкурабельности онкологических пациентов. Зарубежные исследования указывают на то, что в XXI в. онкологические заболевания оказались основной причиной смертности. Смерть от злокачественных образований в России занимает второе место после болезней системы кровообращения. В случае выявления инкурабельности заболевания пациентам показана паллиативная медицинская помощь. Ежегодно около 40 % госпитализаций в хоспис приходятся на онкологическую патологию. В России оказание паллиативной помощи имеет давние истоки, и её характер трансформировался на протяжении всего прошлого века. Целью данной статьи является исторический очерк и обзор актуального состояния хосписного движения в Санкт-Петербурге.
Deuterated reagents in multicomponent reactions to afford deuterium-labeled products
Authors: Schofield Kevin , Maddern Shayna , Zhang Yueteng , Mastin Grace E , Knight Rachel , Wang Wei , Galligan James , Hulme Christopher
Published: September 2024

The utility of bio-isosteres is broad in drug discovery and methodology herein enables the preparation of deuterium-labeled products is the most fundamental of known bio-isosteric replacements. As such we report the use of both [D1]-aldehydes and [D2]-isonitriles across 8 multicomponent reactions (MCRs) to give diverse arrays of deuterated products. A highlight is the synthesis of several FDA-approved calcium channel blockers, selectively deuterated at a t1/2 limiting metabolic soft-spot via use of [D1]-aldehydes. Surrogate pharmacokinetic analyses of microsomal stability confirm prolongation of t1/2 of the new deuterated analogs. We also report the first preparation of [D2]-isonitriles from [D3]-formamides via a modified Leuckart–Wallach reaction and their use in an MCR to afford products with [D2]-benzylic positions and likely significantly enhanced metabolic stability, a key parameter for property-based design efforts.
Sosialisasi Peningkatan Kesadaran Hukum (Tindak Pidana Karena Minuman Keras) di PT. Bio Inti Agrindo
Authors: Fahmi Muhammad Saiful , Klau Ricardo Goncalves , Rado Rudini Hasyim
Published: September 2024

Dalam tatanan masyarakat ada sejumlah nilai sosial yang berlaku, yang tidak jarang banyak dihadapkan pada berbagai kendala, memitigasi kendala tersebut diperlukan dengan pembinaan hukum. Perilaku menyimpang salah satunya adalah minum-minuman keras yang berujung pada tindak pidana. Pembinaan hukum harus dilakukan dengan sebuah pendekatan yang sistemik termasuk di dalamnya budaya hukum. Kepatuhan budaya hukum pada PT.BIA salah satunya dilakukan dengan melakukan penyuluhan hukum. Pengabdian di Area Estate A PT. BIA ini menggunakan metode sosialisai/penyuluhan berupa tindak pidana yang diakibatkan oleh minum-minuman keras dengan teknik ceramah dari narasumber, studi kasus, dan diskusi/tanya jawab. Hasil dari pengabdian kepada masyarakat yang telah dilaksanakan ini disambut dengan respon yang positif oleh para pekerja pada Area Estate A PT. BIA dimana minum-minuman keras memiliki dampak negatif baik diantaranya biasa menyebabkan tindak pidana dan menurunkan produktivitas kerja. Berdasarkan hasil yang diperoleh dari pengabdian ini dapat disimpulkan bahwa sosialisasi hukum ini sangat bermanfaat bagi para pekerja di Area Estate A PT. BIA untuk menumbuhkan rasa kesadaran hukum secara kolektif.
Urgensi Eksistensi BUMDes Pada Kesejahteraan Masyarakat Pedesaan Muara Badak Kabupaten Kutai Kartanegara
Authors: Kadri Fitri Aeli , Nurrahman Alda , Natakusuma Muh. Noviar , Perdianto Bagas Adjie , Salida Andhy Pratama , Nur Insan Tajali
Published: September 2024

Kegiatan ini mengkaji urgensi eksistensi Badan Usaha Milik Desa (BUMDes) dalam meningkatkan kesejahteraan masyarakat Desa Salo Palai, Desa Saliki, dan Desa Badak Baru, Kecamatan Muara Badak, Kabupaten Kutai Kartanegara, Kalimantan Timur. Desa-desa ini dikenal dengan potensi ekonomi yang berbasis sumber daya alam seperti pertanian dan perkebunan, perikanan, dan jasa. Tujuan dari kegiatan ini adalah untuk mengevaluasi peran BUMDes dalam pemberdayaan ekonomi lokal, mengidentifikasi tantangan yang dihadapi, serta merumuskan rekomendasi strategis yang dapat mendukung optimalisasi fungsi BUMDes dalam meningkatkan kesejahteraan masyarakat pedesaan. Melalui BUMDes, pemerintah daerah mendorong pemberdayaan ekonomi lokal dengan mengelola sumber daya secara berkelanjutan. Namun, terdapat beberapa isu yang perlu diatasi, seperti kurangnya sumber daya manusia, transparansi pengelolaan sumber daya alam, pembentukan regulasi BUMDes, serta aspek keadilan dan kemanfaatan bagi seluruh masyarakat desa. Kegiatan ini menggunakan pendekatan deskriptif untuk mengeksplorasi manfaat BUMDes dan tantangan yang dihadapi, dengan fokus pada asas transparansi, keadilan, dan kemanfaatan. Data diperoleh melalui studi literatur dan observasi terhadap praktik BUMDes di tiga desa. Hasil kegiatan menunjukkan bahwa BUMDes memiliki potensi besar dalam meningkatkan ekonomi dan kesejahteraan masyarakat desa, namun perlu dilakukan langkah-langkah strategis untuk mengatasi permasalahan BUMDes yang ada.
Elevating Customer Experience (CX) in Artificial Intelligence (AI) Era
Authors: Zarie Abdullah , Aljohani Faisal , Al-Harbi Mohammed
Published: September 2024

Artificial Intelligence (AI) is transforming the way businesses interact with customers, and that is leading to elevated Customer Experience (CX). This article is mainly talking about how AI has the positive impacts on businesses and consumers in the era of AI. In addition, it discusses and highlights how the AI modern technologies, such as; Natural Language Processing (NLP), sentiment analysis and predictive analytics are being integrated into customer service to enhance personalized interaction with customers. Furthermore, it shed the light on the AI role for creating more efficient and engaging customer journey through chatbots which automate routine tasks and recommend tailored products.
Exploring the Intuitive Salt Measurement Practices of Indian Mothers: A Study Through Mathematical and Machine Learning Lenses
Authors: Verma Amitesh
Published: September 2024

The ability of Indian mothers to intuitively assess the ideal salt levels for different dishes and family members is truly remarkable. They take into account several variables, such as the current weather, the day of the week, the emotional state of the family, portion sizes, and the specific traits of the ingredients used. This research investigates the fundamental processes behind this intuitive approach, developing a detailed mathematical framework to capture the nuances of salt measurement. The measurement of salt in cooking is an intricate art form that intertwines cultural insights, personal experience, and instinctual knowledge. For Indian mothers, the ability to estimate salt without precise instruments is a time-honored culinary skill, passed down through generations. This study investigates the subtleties of this practice by utilizing mathematical modeling and machine learning techniques. By analyzing data collected from a group of Indian mothers, the research aims to quantify and reveal the patterns that guide their intuitive salt measurements. The findings illuminate the balance between precision and intuition in traditional cooking methods and propose avenues for integrating these age-old practices into the realm of modern culinary technology. The model is akin to machine learning algorithms, facilitating the passing down of culinary expertise to future generations. We develop a formula to determine the ideal salt quantity and offer visual aids, including graphs and tables, to demonstrate the relationship between various factors and the amount of salt needed.
Impact of Long-Term Opioid Use on Bone Health
Authors: Kapoor Ashwini , Rana Ashish , Bhothra Maniah
Published: September 2024

A comparative analysis was conducted to examine thirty individuals who use heroin Group A, thirty who abstain Group B, and thirty in terms of demographics, body composition, and hormonal profiles as a control group. Group A demonstrated the lowest median weight and height while Group B exhibited the highest lean body mass. Notable differences emerged in luteinizing hormone, testosterone, bone alkaline phosphatase, parathyroid hormone, calcium/creatinine ratio, and hydroxyproline/creatinine ratio across participants. These dissimilarities were markedly evident when contrasting the control group with Group A and Group B with Group A. The investigation's findings imply that opioid use and subsequent cessation profoundly influence hormone levels and bone metabolism. This underscores the necessity for tailored intervention strategies to specifically address the requirements of these populations.
A maffia kriminológiai sajátosságainak szerepe az olasz büntetőjogban – különös tekintettel a bírói jogalkalmazásra
Authors: Tornyai Gergely
Published: September 2024

The aim of the study is to highlight the different nature of the criminology-legislation-application of the law in Italy compared to the domestic criminal law, at least in the case of mafia cases.
Az orosz rendőrség átalakulása az ezredforduló után – néhány szempont a folyamattal összefüggő vitához
Authors: Szűcs Gáborné
Published: September 2024

The author describes the process of transformation of the Russian police. In his article, the author aims to review the literature on the subject at home, abroad and on the Internet, and to draw conclusions.
Behind the Wheel: Exploring the World of Public Transport Drivers and Perspectives of Passengers at Bosman Taxi Rank, Pretoria, South Africa
Authors: Khoza Sidumo , Khosa Dee , Olutola Adewale
Published: September 2024

The purpose of this study was to improve commuter safety in South Africa’s minibus taxi industry. It is a vital component of the nation’s transportation network that is plagued by road safety concerns due to driver behaviour. A quantitative research approach involving 150 respondents selected through probability sampling was utilised. Data were collected via self-administered questionnaires at Bosman Taxi Rank in Pretoria, Gauteng province, and analysed using the Statistical Package for the Social Sciences (SPSS). The study’s findings revealed severe safety issues faced by public transport passengers, including fatalities and injuries resulting from unsafe practices by minibus taxi drivers. It also highlighted systemic shortcomings in traffic law enforcement, particularly during weekends, which are exacerbated by drivers operating under the influence of alcohol. Recommendations include professionalising the minibus taxi sector, enhancing collaboration between traffic law enforcement agencies and the taxi industry, revising remuneration structures for National Traffic Police officers, establishing passenger-centric organisations, centralising traffic law enforcement mechanisms, improving driver employment conditions, and conducting public road safety awareness workshops. This study contributes to scholarship by providing empirical evidence on the safety challenges within the minibus taxi industry and proposing comprehensive measures to address these issues, ultimately striving for a safer transportation environment for all commuters in South Africa.

Keywords: Commuter Safety, Minibus Taxi Sector, Public Transportation, Road Safety, South Africa
The effect of problem-based learning assisted with concept mapping founded on cognitive style on the creativity of writing exposition text
Authors: Rubiah Rubiah , Degeng I Nyoman Sudana , Setyosari Punadji , Kuswandi Dedi
Published: September 2024

The aim of this research is to obtain another point of view with collaborative problem-based learning to increase writing creativity in the field of scientific work in the form of exposition text by investigating cognitive style as an individual character and using concept mapping media. This study uses descriptive research methods and multivariate analysis is used to provide a clear picture of writing creativity that considers the use of learning methods, concept mapping media, and students’ cognitive style backgrounds. The research subjects were students of the second-semester Islamic religious education study program from the Islamic Senior High School Diniyah Putri Pekanbaru, Indonesia. Sample selection was done by means of cluster random sampling. The sample was divided into two, the experimental class which collected 30 people, and the control class with a number of 30. The cognitive style must be considered in the application of the learning method. Students with field-dependent cognitive styles are more adaptable in collaborative learning. The use of media mapping to foster writing creativity was evident during the research. Concept mapping, which involves higher-order thinking skills, stimulates students to continue to involve the imagination in their creative process. Several educational implications are discussed and can be used as future research directions. The interpretation results are obtained by considering the relevant literature findings.
Pediatric Hospitalist Comanagement of Surgical Patients
Authors: Anderson Shunte
Published: September 2024

There are multiple reasons why pediatric hospitalists become involved in the care of surgical patients. Several are related to postoperative complications or acute medical issues that arise during their hospitalization. Comanagement programs have become increasingly utilized in the care of such patients, providing a different model of collaboration between hospital medicine and surgical providers. Traditionally, pediatric hospital medicine providers were consulted only when acute needs were identified. There has been much added value seen in the use of comanagement models, especially given the increased complexity of pediatric surgical patients and the development of pediatric hospital medicine as a subspecialty. This article will discuss pediatric hospitalist comanagement of surgical patients, including program establishment, potential benefits, and services provided, as well as challenges and additional considerations.

[
Pediatr Ann
. 2024;53(9):e320–e323.]
Overview of Toxic Ingestions in Adolescents
Authors: Hernandez Rebecca I. , Gadhia Hetal
Published: September 2024

There has been an overall increase in the number of suspected suicide attempts by self-poisoning among the adolescent population. Incidences of self-poisoning have increased since the coronavirus 2019 pandemic, particularly among patients age 10 to 19 years. Common agents used in self-poisoning include over-the-counter and prescription medications. It is crucial to identify adolescent patients with risk factors and provide appropriate resources to reduce the likelihood of intentional toxic ingestion. This article aims to summarize the current state of intentional toxic ingestions by adolescents, provide an overview of the most common agents implicated in self-poisoning, and discuss the best practices in screening patients.

[
Pediatr Ann
. 2024;53(9):e330–e336.]
Screening fungi for use as biocatalysts in self-healing concrete with protocol simulating concrete environment
Authors: Sumon Ahsanul Kabir , Invally Krutika , Ju Lu-Kwang
Published: September 2024

This work addresses the problem of having no existent protocol that closely simulates the harsh concrete environment, namely, high pH (about 13) and temperature (up to above 50 °C during cement hydration), for selecting microorganisms to use in microbe-effected self-healing concrete (MESHC). This problem critically impedes the progress of MESHC development, which has tremendous significance because concrete cracking reduces service life while making new concrete consumes substantial energy and emits a large amount of CO2. The objective of this work was to develop an effective and innovative screening protocol that mimics not only the concrete-relevant pH and temperature but also the essential process/scenario of MESHC, that is, microbial spores remain dormant through the harsh conditions during concrete mixing and curing and germinate later at the less harsh condition (pH 9–11, ambient temperature) in concrete cracks. The protocol includes 4 steps with increasing complexity to reduce strains for time-consuming steps. The first 2 steps screen for strains capable of vegetative growth on agar and liquid media with initial pH ≥ 10. Step 3 evaluates the spore germinability in medium with pH gradually decreasing from 12. In Step 4, spores were subjected to both high pH (12, 12.9) and temperature (45, 55 °C) for 2 h before being stored in the high-pH medium at room temperature for up to 21 days. Spores were finally collected and resuspended in pH 9.5 medium to observe germinability. 18 alkalotolerant strains were screened. Scopulariopsis brevicaulis (S. brevicaulis) is identified as the best candidate. Results also indicate the importance of incorporating designs to locally lower pH near spores, at least slightly (from 12.9 to 12), and to limit temperature to below 53 °C. Survivability of S. brevicaulis spores in contact with mortar undergoing cement hydration was also monitored. The work identifies promising fungi and indicates critical directions for developing spore-protection technologies for MESHC.
Influence of menthol on membrane-associated properties of tetracycline-resistant Escherichia coli
Authors: Tadevosyan Silvard , Sahakyan Naira
Published: September 2024

In this investigation, we assessed the antibacterial properties of menthol using Escherichia coli strains, including a tetracycline-resistant (BN407) and a non-resistant reference (K12) strains. The disc-diffusion assay indicated remarkable antibacterial activity of menthol, warranting further exploration. The minimum inhibitory concentration (MIC) for menthol was determined to be 500 µg/ml for both strains. Despite identical MIC values, menthol exhibited different effects on the colony-forming units (CFUs) of the strains, reducing CFUs by 55% in E. coli K12 and 40% in E. coli BN407.

Growth kinetics studies revealed that menthol extended the Lag phase by 50% and decreased the specific growth rate and mean generation time by nearly 50% for both strains. These findings illustrate menthol's significant impact on bacterial replication and adaptation processes. Additionally, menthol disrupted membrane-associated properties, as evidenced by reduced H+-flux through bacterial membranes, affecting both N,N-Dicyclohexylcarbodiimide (DCCD)-sensitive and non-sensitive proton flux rates. This indicates that menthol compromises the proton motive force critical for ATP synthesis and nutrient transport.

In summary, menthol demonstrates potent antibacterial activity, influencing bacterial growth and survival. This activity is supposed to be due to the influence on membrane functionality. These effects are consistent across both tetracycline-resistant and non-resistant E. coli strains.
Robust stabilization of fractional-order hybrid optical system using a single-input TS-fuzzy sliding mode control strategy with input nonlinearities
Authors: Roohi Majid , Mirzajani Saeed , Haghighi Ahmad Reza , Basse-O'Connor Andreas
Published: September 2024

Hybrid optical systems with integrated control mechanisms enable a dynamic adjustment of optical components, ensuring real-time optimization, adaptability to changing conditions, and precise functionality. This control requirement enhances their performance in applications demanding responsiveness, such as autonomous systems, adaptive optics, and advanced imaging technologies. This research introduces a novel approach, employing a dynamic-free Takagi-Sugeno fuzzy sliding mode control (TS-fuzzy SMC) technique, to regulate and stabilize a specific category of chaotic fractional-order modified hybrid optical systems. The method addresses uncertainties and input-saturation challenges within the system. Leveraging a novel fractional calculus definition along with the non-integer type of the Lyapunov stability theorem and linear matrix inequality principle, the TS-fuzzy SMC approach was applied to effectively mitigate and regulate the undesired behavior of the fractional-order chaotic-modified hybrid optical system. Notably, this scheme achieved control without experiencing undesirable chattering phenomena. The paper concludes by offering concrete examples and comparisons, demonstrating how the theoretical findings are applied in real-world scenarios. This provides practical insights into the effectiveness of the proposed approach in diverse applications.
Weighted Lp boundedness of maximal operators with rough kernels
Authors: Al-Qassem Hussain , Ali Mohammed
Published: September 2024

In this paper, we study the weighted spaces $ L^p(\omega, \mathbb{R}^d) $ boundedness of certain class of maximal operators when their kernels belong to the space $ L^{q}(\mathbb{S} ^{d-1}) $, $ q > 1 $. Our results in this paper are improvements and extensions of some previously known results.
The Contribution of Improvised Play to the Personality Development of Preschool Children
Authors: Stelianou Antonia , Dalapera Evagelia , Christodoulou Pineio
Published: September 2024

The present study is a participatory action research entitled “I Learn, Play, and Have Fun With Toys I Make,” which was carried out in a kindergarten, with the participation of the teachers and the preschool students who attended it. The aim of this action research was to upgrade and enrich the educational material in a playful way, by making improvised games, which facilitate and expand the teaching process of the teachers and the learning process of the students. The action research focused primarily on the active involvement of the participating kindergarten students regarding the construction of improvised educational materials, primarily with recyclable materials. As for the research tools, participatory observation, the semi-structured interview, the questionnaire for parents and students, as well as the diary of the participating teachers were selected and used as the most appropriate. The results showed that the specific action research had many benefits for the participating students. An effect on the all-round and balanced development of the students' personalities was evident.
A Review-Based Theoretical Analysis on Somatization of Psychological Symptoms and Physical Manifestation of Trauma in Youths
Authors: Singh Aastha , Singh Ravindra , Singh Ajay Kumar
Published: September 2024

Early trauma is caused to increase disease among youth. It also has an adverse impact on brain development and impairs the various other facets of daily life functioning of youth. This chapter, thus, provides a systematic outline of physical manifestations of long-term psychological trauma and the somatization of psychological symptoms among youth. The summary of 50 research articles and book chapters are included in this chapter. A systematic method is employed to collect and synthesize information. The authors have screened open-sourced articles published in English available in the public domain which were published after 2000 using various keywords such as youth, psychological trauma, somatization, and childhood maltreatment. It supports the idea that prolonged exposure to trauma results in physical symptoms like exhaustion, fatigue, high blood pressure, and anxiety among youth. It may also be responsible for increasing various diseases like diabetes and abuse disorders among youth.
Time Series Data Investigation for Assessing the Impact of Chinese Exports and Imports on India-Japan Bilateral Trade Relations
Authors: Singh Ajay Kumar
Published: September 2024

This chapter perceives the Chinese effect on India-Japan bilateral trade relations. Thereupon, it adopted a log-linear regression model to detect the Chinese effect on India-Japan bilateral trade relations. Export and import of India with China have a positive impact on export of India with Japan. GDP of China and Japan, total population of Japan and official exchange rate of India have a positive impact on exports of India with China. AHS total tariff lines of India-Japan, import of India with China, GDP of China and Japan, and total population of China and Japan have a positive impact on import of India with Japan. While export of India with China; AHS and MFN total tariff lines of India with China; GDP of India; total population of India; official exchange rate of China, India and Japan have a negative impact on import of India with Japan.
Editorial Forward
Authors: Rosairo H. S. R.
Published: September 2024

Abstract is not available
Reading habits of student teachers studying at a distance-learning institution in South Africa
Authors: Le Roux Sarlina G.
Published: September 2024

Background: South Africans are widely perceived as not being a reading nation. For many South African children, their first encounter with books and stories occurs when they formally enter the schooling system. This raises the question of how teachers understand their role as reading role models.Objectives: This article aims to investigate how pre-service teachers who are registered at an open distance learning institution evaluate their reading habits.Method: The study employed phenomenography as a research design. All students registered for the Children’s Literature module in 2023 were invited to participate in the study. The submissions of a formal forum discussion assessment of students who agreed to participate in the study were analysed and arranged in themes and codes using Atlas.ti.Results: The article shows that most students perceive themselves as readers, though for varied reasons. The findings suggest the rejection of a monolithic definition of a reader identity. Instead, the notion of categories of readers provides more valuable information for understanding reading behaviour and reader identities.Conclusion: This study confirmed that pre-service teachers are aware of the benefits of reading, though their actions to improve their reading ability, are inadequate.Contribution: Since pre-service teacher training is arguably an important opportunity for addressing the literacy crisis, the findings of this study emphasise the important role of teachers as reading role models.
Computer Modeling and Parameter Estimation of Power Battery Performance for New Energy Vehicles under Hot Working Conditions
Authors: Zhang Hua
Published: September 2024

With the aggravation of environmental pollution problems and the reduction of non-renewable energy sources such as oil, new energy vehicles have gradually become the focus of attention, and the application of their power batteries has become more and more widespread. The state of energy (SOE) of the power battery is an important basis for energy scheduling. Therefore, the study used computer technology to develop an analogous model of the power battery and evaluated its properties at various temperatures in order to precisely analyze the performance of the battery under thermal conditions. At the same time, to address the limitations in parameter estimation, the study uses the improved Kalman filter (KF) algorithm to optimize it. The results revealed that the estimation errors of the improved cubature Kalman filter (CKF) algorithm were reduced by 0.52%, 2.91% and 3.10% compared with the traditional CKF algorithm, EKF algorithm and UKF algorithm, respectively. In summary, the research on computer modeling and parameter estimation of the performance of new energy vehicle power batteries under hot working conditions provides important support and reference for the efficient operation and safety of new energy power batteries under hot working conditions.
A new cubichnium ichnogenus and ichnospecies, Pygocephalichnium reidi, from the Pennsylvanian UNESCO World Heritage Site at Joggins Fossil Cliffs, Canada, and associated ichnotaxa
Authors: Malay Bailey C. , Stimson Matthew R. , King Olivia A. , Faulkner Sal , Heberts Brian L. , Calder John H. , MacRae R. Andrew , Lucas Spencer G.
Published: September 2024

The Carboniferous Joggins Fossil Cliffs UNESCO World Heritage Site in Nova Scotia, Canada, has long been known for its extensive paleobiodiversity. The ichnofossil record at Joggins is less known than the body fossil record. Amongst the extensive ichnological collections of the late citizen-scientist Donald Reid is a morphologically unique shrimp-shaped cubichnium (resting trace). The trace fossil is associated with a faint invertebrate trackway that leads up to the resting trace and establishes its identification as an invertebrate resting trace. The trace fossil was recovered from the upper Joggins Formation (876 m above the base), and was found in finegrained, rippled sandstones interpreted to be from an open-water to poorly drained lithofacies assemblage transition. The trace fossil slab studied here also has examples of the invertebrate resting traces Selenichnites and Rusophycus preserved in convex hyporelief; these traces are commonly attributed to horseshoe crabs and crustaceans, respectively. They co-occur in the same stratigraphic horizon with Kouphichnium trackways, interpreted to be produced by xiphosurans. The upper Joggins Formation has previously yielded body fossils of Pygocephalus shrimp preserved in organic-rich limestones and sideritic-ironstone nodules. Pygocephalus body fossils are common at Joggins, but no trace fossils have been assigned to this invertebrate, perhaps having gone unrecognized until now. The trace fossil newly described here as Pygocephalichnium reidi is interpreted to have been produced by a Pygocephalus shrimp based on its morphological similarities to known body fossils from the Joggins Formation, and we propose that this new trace fossil morphology warrants a new ichnotaxon, Pygocephalichnium reidi.
‘What are they thinking of?’
Authors: Grenfell Michael
Published: September 2024

This article explains the thinking underlying recent activism in digital markets by competition regulators – with reference to cases undertaken by the CMA, the European Commission and the US authorities, and to the new UK and EU regulatory regimes for competition in digital markets. It addresses some common misconceptions about competition authorities’ thinking on digital markets, and identifies strategies most likely to be effective for tech companies in dealing with competition authorities.

It argues that: (i) the consumer and competition benefits brought by the tech industry are real and substantial; (ii) contrary to common belief, these benefits are recognized by competition authorities; (iii) recent competition regulatory activism should be understood in the context of a belief that it is necessary to preserve those benefits, by allowing new generations of tech disruptors to emerge; (iv) when tech companies face competition investigations or interventions, they should resist the temptation to kneejerk dismissal of all possible concerns, which is unlikely to be effective in advancing their business interests, because it misunderstands the authorities’ thinking; and (v) smarter strategies involve engaging with the specific facts of a particular case (economic, legal and technical) to challenge whether proposed interventions or remedies are, in reality, both effective and proportionate.
Ex-post assessment of merger remedies: the CMA’S 2023 merger remedy evaluations
Authors: Garland Colin , Pantling Steve , Kiritharan Kapileshen
Published: September 2024

Evaluating the impact and implementation of interventions is an important aspect of public policy. Evaluations help policymakers understand what worked well and what has been less successful. They provide the basis for continuous improvement and can drive legislative reform and policy development, as well as informing future interventions. This article considers the findings of the CMA’s most recent update in its merger remedy evaluation programme, which focussed on the learnings from a set of merger case studies where the CMA required ‘carve-out’ divestiture remedies to be implemented. This recent research highlights the generally higher risk profile of carve-out remedies compared to the divestiture of stand-alone business units, which decision makers will need to take into account before concluding whether such a remedy will be effective.
Polska adaptacja kwestionariuszy Loyolska skala generatywności oraz Lista zachowań generatywnych
Authors: Bandel Jerzy , Soroko Emilia , Sękowski Marcin
Published: September 2024

This article presents the results of the Polish adaptation of McAdams and de St. Aubin’s Loyola Generativity Scale (LGS) and Generative Behaviour List (GBC) – the scales respectively measure generative concern and generative behaviour. Results from a sample of N = 237 individuals aged 19–93 years showed good internal reliability of the LGS and GBC. Their results correlated positively. Most hypotheses supporting the criterion-relevance of the LGS and GBC were confirmed, including showing positive correlations of both scales with the intensity of meaning in life, extroversion and openness to experiences, as well as a negative correlation of the LGS with depressive symptoms. The CFA supported the original two-factor model of the LGS. In addition, the high stability of LGS scores over a three-week period in a sample of N = 30 students was shown. The Polish adaptations of the LGS and the GBC are reliable and valid tools and can be used in research work.
Wypalenie rodzicielskie wśród rodziców dzieci z niepełnosprawnościami i chorobami przewlekłymi
Authors: Dzielińska Michalina , Lasota Marta , Piotrowski Konrad
Published: September 2024

The purpose of this study was to assess the severity of parental burnout among parents of children with disabilities and chronic illness. It was hypothesized that these parents would be characterized by higher levels of parental burnout and that their child’s disability and chronic illness would moderate the relationship of parental burnout with sociodemographic factors. The study was conducted with 254 parents (Mage = 35.37 years; SDage = 5.80) with children aged one month to 35 years; 22% of parents had a child with a disability or chronic illness. The Parental Burnout Assessment (PBA) questionnaire was used to verify the research hypotheses. The correlation analyses showed that parents of children with disabilities had higher levels of parental burnout, and as the degree of constraints related to the child’s difficulties increased, the level of parental burnout increased. The moderation analyses proved to be statistically significant for the relationship between the number of children and parental burnout. Similar relationships were not found concerning the relationship of parental burnout with the fact of having a child under five or the gender of the parent. The study indicated that there are relationships between having a child with a disability or chronic illness, the degree of their limitations, and parental burnout.