bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-Level Feature Fusion in CNN-Based Human Action Recognition: A Case Study on EfficientNet-B7
Authors: Lueangwitchajaroen Pitiwat , Watcharapinchai Sitapa , Tepsan Worawit , Sooksatra Sorn
Published: December 2024

Accurate human action recognition is becoming increasingly important across various fields, including healthcare and self-driving cars. A simple approach to enhance model performance is incorporating additional data modalities, such as depth frames, point clouds, and skeleton information, while previous studies have predominantly used late fusion techniques to combine these modalities, our research introduces a multi-level fusion approach that combines information at early, intermediate, and late stages together. Furthermore, recognizing the challenges of collecting multiple data types in real-world applications, our approach seeks to exploit multimodal techniques while relying solely on RGB frames as the single data source. In our work, we used RGB frames from the NTU RGB+D dataset as the sole data source. From these frames, we extracted 2D skeleton coordinates and optical flow frames using pre-trained models. We evaluated our multi-level fusion approach with EfficientNet-B7 as a case study, and our methods demonstrated significant improvement, achieving 91.5% in NTU RGB+D 60 dataset accuracy compared to single-modality and single-view models. Despite their simplicity, our methods are also comparable to other state-of-the-art approaches.
Biotransformation of the Fluoroquinolone Antibiotic, Levofloxacin, by the Free and Immobilized Secretome of Coriolopsis gallica
Authors: Staita Karima , Khmaissa Marwa , Akrout Imen , Greff Stéphane , Ghariani Bouthaina , Turbé-Doan Annick , Lambert Julien , Lomascolo Anne , Albert Quentin , Faulds Craig B. , Sciara Giuliano , Zouari-Mechichi Héla , Record Eric , Mechichi Tahar
Published: December 2024

Antibiotics play a crucial role in human and animal medical healthcare, but widespread use and overuse of antibiotics poses alarming health and environmental issues. Fluoroquinolones constitute a class of antibiotics that has already become ubiquitous in the environment, and their increasing use and high persistence prompt growing concern. Here we investigated a fungal secretome prepared from the white-rot fungus Coriolopsis gallica, which is able to effectively degrade the environmentally persistent fluoroquinolone, levofloxacin. We tested various physical–chemical factors such as concentrations of 1-hydroxybenzotriazol (HBT), of enzyme, and of antibiotic, and pH and temperature of the reaction for biotransformation of the antibiotic. We compared the free with the immobilized Coriolopsis gallica secretome proteins, and analyzed the collective reaction products for residual activity against E. coli (growth inhibition test). We also performed HPLC analysis. The results show that treatment with the free secretome yielded a highest removal efficiency of 50 mg L−1 levofloxacin in the presence of 2.5 mM HBT, whereas the immobilized secretome was only able to degrade 10 mg L−1 levofloxacin with the same concentration of mediator, but presenting the advantage of being reusable.
The Formulation, Preparation, and Evaluation of Celecoxib Nanosuspensions: Nanosizing via High-Pressure Homogenization and Conversion of the Nanosuspensions into Dry Powders by Spray Drying and Freeze Drying
Authors: Machamasi Rukesh , Hwang Sung-Joo , Dinh Linh
Published: December 2024

Celecoxib (CEL), a nonsteroidal anti-inflammation drug (NSAID), is categorized as a Class II drug (low solubility, high permeability) in the Biopharmaceutics Classification System (BCS). The aim of this study is to develop a novel formulation of CEL nanosuspensions in the form of dried powder for tableting or capsuling. In this study, CEL was formulated into nanosuspensions to improve its solubility. CEL nanosuspensions were prepared using the precipitation method followed by high-pressure homogenization. Drying of the nanosuspensions was performed by spray drying and freeze drying. We examined the impact of various formulation and processing parameters on the nanoparticles. The CEL nanoparticles were characterized by particle size analysis, differential scanning calorimetry (DSC), powder X-Ray diffraction (PXRD), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and dissolution tests. The choice of solvent, stabilizer, and surfactant appeared to have significant impacts on the crystallization and particle size and, consequently, the solubility of the CEL nanoparticles. CEL chemical stability was maintained throughout both drying processes. Both spray-dried and freeze-dried CEL nanosuspensions showed rapid dissolution profiles compared to raw CEL due to the nanosized particle dispersion with the presence of a lag phase. The freeze-dried nanosuspension showed a slight delay in the first 20 min compared to the spray-dried nanosuspension, after which dissolution progressed with a lag phase that represents aggregation.
Improving the Quality of the Water Flowing over a Stepped Spillway in Open Canals by Increasing Its Degree of Aeration
Authors: Ashour Mohamed A. , Ali Mohamed Khairy , Aly Tawab E.
Published: December 2024

As spillways are hydraulic structures constructed for the safe release of floodwater from the upstream (US) side of a dam to the downstream side, or from the end of canals and drains to a lower stream, the upstream water flow of such structures gains significant amounts of potential energy. As this water flows over a spillway or escapes, the gained potential energy is converted into kinetic energy, resulting in the water gaining an increasing velocity, thereby enhancing the flow’s destructive potential. This can have a harmful impact on the hydraulic performance and the structural stability of the spillway itself. To avoid such harmful effects, engineers and designers of such structures usually provide the spillways and water escapes with some tools for dissipating that kinetic energy and decreasing the flowing water’s velocity. The present study aims to enhance the performance efficiency of such dissipating tools, as well as to improve the quality of the flowing water by leveraging the significant turbulence generated by the existing energy dissipators on the back of the spillway body. The aeration process enabled by this turbulence increases the dissolved oxygen contents, thereby enhancing the water quality, which is one of the main objectives of this work. On the back surface of the spillway, various dissipater shapes with different geometrical configurations, dimensions, and combinations were tested, in order to determine the most suitable engineering treatments for maximizing the dissolved oxygen content and improving the water quality for various uses, as the study’s main goal. By testing 21 different model configurations with the available laboratory discharges, the study successfully identified the most effective shape and properties of the desired dissipator, which increased the dissolved oxygen content by an average of 21.70% and dissipated water energy by about 69%.
Loving the Sport, Loving the Self: Devotion and Defiance in Furia
Authors: Glenn Wendy J.
Published: December 2024

In the world of sports today, young people have access to models of women athletes who seem to have it all, women whose actions push on gendered assumptions of love and the associated roles of women as sacrificial and subservient. And yet, young people, particularly young girls, wanting to navigate their worlds in ways that challenge conventional love, do not have the same power and privilege given their gender, age, and lack of financial autonomy. The young adult novel Furia invites young readers to evidence an adolescent character whose love of sport serves as a form of liberation from social constraints in a way that likely feels more resonant and doable, more real somehow. The protagonist’s engagement with and dedication to sport invite complications of ideological assumptions about love, particularly gendered narratives that position girls and women as bound by devotion This paper draws upon the youth lensand methods of critical context analysis to better understand how the protagonist is positioned as an athlete and a young woman and to offer interpretative thinking that explores how this title can help us (and young readers) think about love through the lens of sport.
Statin Use in Metabolic Dysfunction-Associated Steatotic Liver Disease and Effects on Vibration-Controlled Transient Elastography-Derived Scores—A Population-Based Inverse Probability Treatment Weighting Analysis
Authors: Polpichai Natchaya , Saowapa Sakditad , Jaroenlapnopparat Aunchalee , Sierra Leandro , Danpanichkul Pojsakorn , Fangsaard Panisara , Wattanachayakul Phuuwadith , Kaewdech Apichat
Published: December 2024

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease globally. The impact of statins on liver fibrosis severity in MASLD individuals remains uncertain, despite their known cardiovascular benefits. Methods: A cross-sectional study was performed utilizing the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2018. MASLD was defined by hepatic steatosis (controlled attenuation parameter [CAP] score ≥ 288 dB/m) without other etiologies. Using inverse probability treatment weighting to minimize confounding, we examined the association between statin use and MASLD outcomes, including at-risk steatohepatitis (FibroScan-aspartate aminotransferase [AST] [FAST] score ≥ 0.67), significant and advanced fibrosis (liver stiffness measurement [LSM] ≥ 8.8 kilopascals [kPa] and ≥ 11.7 kPa), and advanced fibrosis (AGILE 3+ score ≥ 0.68). Results: Of 1283 MASLD patients, 376 were prescribed statins within the past 30 days. After adjustment for confounders, statin use was significantly associated with reduced risks of at-risk steatohepatitis, significant fibrosis, and high AGILE 3+ scores, with odds ratios (ORs) of 0.29 (95% CI: 0.01 to 0.87), 0.54 (95% CI: 0.31 to 0.95), and 0.41 (95% CI: 0.22 to 0.75), respectively. However, a subgroup analysis showed this effect persisted only with lipophilic statins. Conclusions: Statin use was associated with reduced steatohepatitis and fibrosis in patients with MASLD, supported by robust causal inference and vibration-controlled transient elastography-derived scores.
The Potential of Polymers and Glass to Enhance Hydrogen Storage Capacity: A Mathematical Approach
Authors: Ratoi Andrei , Munteanu Corneliu , Eliezer Dan
Published: December 2024

This manuscript contributes to understanding the role of hydrogen in different materials, emphasizing polymers and composite materials, to increase hydrogen storage capacity in those materials. Hydrogen storage is critical in advancing and optimizing sustainable energy solutions that are essential for improving their performance. Capillary arrays, which offer increased surface area and optimized storage geometries, present a promising avenue for enhancing hydrogen uptake. This work evaluates various polymers and glass for their mechanical properties and strength with 700 bar inner pressure loads within capillary tubes. A theoretical mathematical approach was employed to quantify the impact of material properties on storage capacity. Our results demonstrate that certain polymers (e.g., Zylon AS, Dyneema SK99) and glass types (S-2 Glass) exhibit superior hydrogen storage potential due to their enhanced strength and low density. These findings suggest that integrating the proposed materials into capillary array systems can significantly improve hydrogen storage efficiency (15–37 wt.% and 37–40 g/L), making them viable candidates for next-generation energy storage systems. This study provides valuable insights into material selection and structural design strategies for high-capacity hydrogen storage technologies.
Evolution of Chemical, Structural, and Mechanical Properties of Titanium Nitride Films with Different Thicknesses Fabricated Using Pulsed DC Magnetron Sputtering
Authors: Mao Wei , Qi Runze , Wu Jiali , Zhang Zhe , Wang Zhanshan
Published: December 2024

Considering the application of titanium nitride (TiN) films as a release layer in producing Wolter-I X-ray telescope mirror shells by the electroformed nickel replication (ENR) technique, this research pays attention to the influence of nanometer-scale thickness variation in the microstructure and physical properties of TiN films deposited by the pulsed direct current (DC) magnetron sputtering method. This topic has received limited attention in the existing literature. TiN films (9.8 nm to 42.9 nm) were fabricated to comprehensively analyze the evolution in microstructure, depth distribution of elements, surface morphology, and intrinsic stress. With increasing thickness, TiN transitioned from amorphous to (200) and (111)–(200) mixed-oriented crystallization, explaining inflection points in the increasing roughness curve. Elements (C, N, O, Si, and Ti) and chemical bond proportions (Ti-N, Ti-N-O, and Ti-O) varied with film depth, and the fitting of film density can be optimized according to these variations. Crystallite size increased with thickness, which led to a reduction in intrinsic stress. It is evident that as film thickness increases, TiN forms a stable crystal structure, thereby reducing intrinsic stress, but resulting in increased roughness. Considering the impact of changes in thin film thickness on physical properties such as roughness, crystallinity, and intrinsic stress, a TiN film with a thickness of approximately 25 nm is deemed suitable for application as a release layer.
Characterization of the Optical Properties of Photoluminescent Turbid Media Using an Integrating Sphere and Monte Carlo Simulations
Authors: Jelken Joachim , Brall Thomas , Gelbing Philip , Foschum Florian , Kienle Alwin
Published: December 2024

In this paper, we report on the measurement of the optical properties (absorption and scattering coefficients) of photoluminescent turbid media using a homemade integrating sphere setup equipped with a tunable monochromatic light source. The hemispherical reflectance and transmission data are analyzed with the radiative transfer equation using a Monte Carlo simulation-based lookup table to obtain the optical properties of the sample. The results are compared with the optical properties received from a classical integrating sphere setup equipped with a broadband white light source. The additional light of the photoluminescence generates artifacts within the optical properties, which are not present using a monochromatic light source. Additionally, a batch of samples with a broad range of scattering coefficients and dye concentrations were prepared and characterized with the aforementioned setup. The findings can help to generate a digital twin with the optical properties of the sample, which improves the physically based rendering and the design of, e.g., white-light LEDs. Dental restoration and photodynamic therapy also benefit from determination of the optical properties of photoluminescent turbid media.
A Novel Objective Method for Steel Degradation Rate Evaluation
Authors: Kasińska Justyna , Malinowski Paweł , Matusiewicz Piotr , Makieła Włodzimierz , Barwicki Leopold , Bolibruchova Dana
Published: December 2024

This article introduces a novel approach for assessing microstructure, particularly its degradation after extended operation. The authors focus on creep processes in power plant components, highlighting the importance of diagnostics in this field. This article emphasizes the value of combining traditional microstructure observation techniques with image analysis. A non-destructive method of evaluating microstructure parameters (matrix replicas) is presented, and its accuracy is evaluated against the conventional destructive method. The assessment utilizes quantitative data derived from classical stereological principles and image analysis. Parameters like mean chord length, relative surface area, mean cross-sectional area, and mean equivalent diameter are compared for replica and metallographic specimens. The results show that the replica method accurately reproduces the microstructure. In their conclusions, the authors highlight the importance of developing visual methods alongside the application of artificial intelligence while indicating the challenges in achieving this goal.
Effects of Building Orientation and Raster Angle on the Mechanical Properties of Selected Materials Used in FFF Techniques
Authors: Dziewit Piotr , Rajkowski Kamil , Płatek Paweł
Published: December 2024

Advances in the development of additive manufacturing materials (AM) and the low availability of studies on the impact response of AM specimens are the main reasons for this paper. Therefore, the influence of building orientation (vertical and horizontal) and the angle of the raster (15°/−75°, 30°/−60°, 45°/−45°, and 0°/90°) on the tensile and impact strength of AM specimens was investigated. The polylactic acid (PLA)-PolyMax, Mediflex and acrylonitrile-butadiene-styrene (ABS) filaments were chosen to provide a comprehensive characterization of AM materials with versatile mechanical properties. The experimental results of this study show that the tensile strength and toughness of PolyMax PLA specimens are comparable to ABS specimens, while Mediflex samples are characterized by their higher toughness, but lower impact force needed to break the samples. The Mediflex Charpy fracture surfaces exhibit a ductile character compared to those of brittle ABS and PLA. Furthermore, fracture surface morphology shows the allocation of voids, which helps us to understand differences in mechanical properties, and allows one to properly interpret the results of the geometrical accuracy of AM specimens with various printing settings.
Comparison of the Finite Element Method and Rigid Finite Element Method During Dynamic Calculations of Steel–Concrete Composite Beams Based on Experimental Results
Authors: Abramowicz Małgorzata , Pełka-Sawenko Agnieszka
Published: December 2024

Dynamic analysis of structures is a key challenge in structural engineering, especially in choosing effective and accurate numerical methods. Steel–concrete composite structures, commonly used in bridges and floors, require calculations of dynamic parameters to ensure safety and comfort. Few studies compare the effectiveness of the finite element method (FEM) and the rigid finite element method (RFEM) in the dynamic analysis of such structures. This study fills this gap by comparing the methods using experimental results. FEM and RFEM models were developed using Abaqus, Python, and Matlab. The main parameters were identified, i.e., the Young’s modulus of the concrete slab (EC) and the stiffness of the connection (Kx, KRX, Kv, Kh). Both methods closely matched the experimental results. The RFEM matched natural frequencies with 2–3% deviations, while the FEM showed 3–4% deviations for the torsional, axial, and first three flexural frequencies. The RFEM reduced the computation time by about 65%, making it suitable for large-scale applications. The FEM provided a finer resolution of local effects due to its higher element density. The results can be applied to the design of bridges, floors, and other structures under dynamic loads. It will also provide the authors with a basis for developing structural health monitoring (SHM).
Engineering Mononuclear Ln(III) Complexes with a Pseudo-Macrocyclic Hexadentate N4O2 Schiff Base Ligand Exhibiting Slow Magnetic Relaxation
Authors: Diaz-Ortega Ismael Francisco , Ye Yating , Jover Jesus , Ruiz Eliseo , Colacio Enrique , Herrera Juan Manuel
Published: December 2024

We report here the synthesis of a series of nine coordinated mononuclear LnIII complexes [LnL1Cl2(DMF)]Cl·2.5DMF and [LnL1(L2)2]Cl·4CH3OH (LnIII = GdIII, DyIII, ErIII and YbIII, HL2 = 9-anthracenecarboxylic acid), where L1 is a hexadentate N4O2 Schiff base ligand prepared from the condensation of 1,10-phenanthroline-2,9-dicarbaldehyde and semicarbazone. The X-ray crystal structures of these complexes show the LnIII ions to possess LnN4O2Cl2 and LnN4O4 coordination spheres, which can be considered to be derived from a hexagonal bipyramidal geometry, with the ligand in the equatorial plane and the anions (chloride or 9-antracenecarboxylate) in axial positions, which undergo distortion after coordination of either a molecule of DMF or a bidentate coordination of the 9-anthracenecarboxxylate ligand. All these compounds exhibit field-induced slow magnetization relaxation (SMR). The absence of SMR at zero field due to QTM, as well as the processes involved in the magnetic relaxation under a field of 0.1 T, have been justified on the basis of theoretical calculations and the distortion of the respective coordination spheres. The severe discrepancy between the calculated and experimental thermal energy barriers for the DyIII complexes seems to indicate that the relaxation occurs with the contribution of spin–vibrational coupling, which is favored by the flexibility of the ligand.
Predictive Value of Inflammatory Scores for Left Atrium Thrombosis in Ischemic Stroke Without Atrial Fibrillation
Authors: Cicek Vedat , Kilic Sahhan , Dogan Selami , Erdem Almina , Babaoglu Mert , Yilmaz Irem , Karaismail Salih , Atmaca Murat Mert , Hayiroglu Mert Ilker , Cinar Tufan , Bagci Ulas
Published: December 2024

Background and Objectives: Studies have shown that inflammation markers can be used as prognostic tools in predicting acute ischemic stroke. In this study, we conducted a comparison of several inflammation scores in predicting left atrial thrombosis (LAT) in patients with ischemic stroke without AF. Materials and Methods: In this single-center, retrospective study, we included 303 consecutive patients with ischemic stroke. Each patient underwent a transesophageal echocardiography (TEE) examination within 10 days of admission to detect the presence of LAT. To identify independent predictors of LAT, we conducted a multivariate logistic regression analysis. Results: In total, 303 patients who had ischemic stroke were included in the analysis. LAT was detached in 34 patients at the time of the TEE examination. The patients were categorized into two groups based on their LAT status. The Prognostic Nutritional Index (PNI), HALP score, and C-reactive Protein–Albumin Ratio (CAR) were identified as statistically significant predictors of LAT. Based on the results of the multivariate regression analysis, the CAR emerged as the only independent predictor of LAT. Conclusions: Among several inflammation scores, the PNI, HALP, and CAR were statistically significant predictors of LAT in ischemic stroke patients without AF. CAR was identified as the optimal score for the prediction of LAT in patients with stroke and without AF.
Artificial Intelligence-Assisted Segmentation of a Falx Cerebri Calcification on Cone-Beam Computed Tomography: A Case Report
Authors: Issa Julien , Chidiac Alexandre , Mozdziak Paul , Kempisty Bartosz , Dorocka-Bobkowska Barbara , Mehr Katarzyna , Dyszkiewicz-Konwińska Marta
Published: December 2024

Intracranial calcifications, particularly within the falx cerebri, serve as crucial diagnostic markers ranging from benign accumulations to signs of severe pathologies. The falx cerebri, a dural fold that separates the cerebral hemispheres, presents challenges in visualization due to its low contrast in standard imaging techniques. Recent advancements in artificial intelligence (AI), particularly in machine learning and deep learning, have significantly transformed radiological diagnostics. This study aims to explore the application of AI in the segmentation and detection of falx cerebri calcifications using Cone-Beam Computed Tomography (CBCT) images through a comprehensive literature review and a detailed case report. The case report presents a 59-year-old patient diagnosed with falx cerebri calcifications whose CBCT images were analyzed using a cloud-based AI platform, demonstrating effectiveness in segmenting these calcifications, although challenges persist in distinguishing these from other cranial structures. A specific search strategy was employed to search electronic databases, yielding four studies exploring AI-based segmentation of the falx cerebri. The review detailed various AI models and their accuracy across different imaging modalities in identifying and segmenting falx cerebri calcifications, also highlighting the gap in publications in this area. In conclusion, further research is needed to improve AI-driven methods for accurately identifying and measuring intracranial calcifications. Advancing AI applications in radiology, particularly for detecting falx cerebri calcifications, could significantly enhance diagnostic precision, support disease monitoring, and inform treatment planning.
The Comparative Efficacy of Burs Versus Piezoelectric Techniques in Third Molar Surgery: A Systematic Review Following the PRISMA Guidelines
Authors: Franco Rocco , Di Girolamo Mattia , Franceschini Carlo , Rastelli Sofia , Capogreco Mario , D’Amario Maurizio
Published: December 2024

Background and Objectives: Third molar (wisdom tooth) extraction is one of the most common surgical procedures in oral and maxillofacial surgery. Traditional rotary instruments and burs have long been the standard tools for this procedure. However, recent advancements in surgical techniques, such as piezoelectric surgery, have gained popularity due to their purported advantages in terms of precision, safety, and postoperative outcomes. This systematic review aims to evaluate the efficacy, safety, and clinical outcomes of third molar surgery performed using burs versus piezoelectric surgery. Materials and Methods: This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was performed using the PubMed, Scopus, Web of Science, and Cochrane databases to identify relevant studies published up until October 2024. Randomized controlled trials (RCTs), clinical trials, and comparative studies assessing third molar surgery using either burs or piezoelectric instruments were included. The primary outcomes evaluated were surgical time, postoperative pain, swelling, nerve damage, and healing time. The data extraction and quality assessment were performed independently by two reviewers using standardized tools, and any discrepancies were resolved by a third reviewer. Results: A total of five studies met the inclusion criteria, and the meta-analysis revealed that piezoelectric surgery resulted in significantly lower postoperative pain and swelling compared to traditional bur techniques (p < 0.05). Additionally, the incidence of nerve injury was lower in the piezoelectric group, though the difference was not statistically significant. Surgical time was found to be longer with piezoelectric devices, but this was offset by improved healing outcomes and patient comfort. Conclusions: Piezoelectric surgery offers a less traumatic alternative to traditional burs for third molar extraction, with reduced postoperative morbidity and enhanced patient outcomes. Although the longer surgical duration may be a drawback, the overall benefits, particularly in terms of pain management and tissue preservation, support the adoption of piezoelectric techniques in clinical practice. Further high-quality randomized trials are recommended to strengthen the evidence base for these findings.
Post-Processing of AM-EBM Ti6Al4V for Biomedical Applications: Evolution of Mechanical Properties as a Function of Surface Roughness
Authors: Valencia-Cadena Andrea , Hangen Ude , Roa Rovira Joan Josep
Published: December 2024

Post-processing, and particularly the dry electropolishing process, is essential for improving the surface quality of 3D-printed Ti6Al4V samples, with specific emphasis on reducing roughness over extended polishing times while preserving mechanical properties. Reducing surface roughness enhances the reliability of hardness measurements and improves the consistency of elastic modulus measurements, as prolonged polishing time stabilizes the full width at half maximum values, thereby minimizing variability due to uniaxial indentation. This stability is crucial for maintaining the structural integrity and uniformity of mechanical properties, facilitating better performance and reliability in biomedical applications. Additionally, under service-like working conditions, solid electrolyte particles undergo dehydration due to the Joule effect, introducing a dynamic aspect to the system as the particle structure degrades with thermal cycling. EDX cross-sectional analysis reveals that TiO2 informs the particle’s surface, with an oxygen-to-titanium ratio that confirms the oxide’s composition. This TiO2 oxide layer demonstrates the progressive surface oxidation occurring under the post-processing process, further modifying the particle’s surface chemistry. This dual effect of roughness reduction and controlled surface chemistry highlights the role of dry electropolishing in enhancing the functional lifespan and mechanical reliability of Ti6Al4V components.
Ultrasound Corrosion Mapping on Hot Stainless Steel Surfaces
Authors: Tai Jan Lean , Sultan Mohamed Thariq Hameed , Shahar Farah Syazwani , Łukaszewicz Andrzej , Oksiuta Zbigniew , Grzejda Rafał
Published: December 2024

This study investigates the application of Phased Array Corrosion Mapping (PACM) as a non-destructive testing (NDT) method for detecting and monitoring corrosion growth on hot stainless steel (SS) surfaces, specifically focusing on SS 304 and SS 316. Conducted across a temperature range of 30 °C to 250 °C, the research evaluates the effectiveness of PACM in high-temperature environments typical of the petrochemical industry. Experiments were conducted using specimens with machined slots and flat-bottom holes (FBHs) to simulate corrosion defects. The results demonstrate that PACM effectively detects and maps corrosion indicators, with color-coded C-scan data facilitating easy interpretation. Temperature variations significantly influenced ultrasound signal characteristics, leading to observable changes in FBH indications, particularly at elevated temperatures. Increased ultrasound attenuation necessitated adjustments in decibel settings to maintain accuracy. SS 304 and SS 316 exhibited distinct responses to temperature changes, with SS 316 showing higher dB values and unique signal behaviors, including increased scattering and noise echoes at elevated temperatures. Detected depths for slots and FBHs correlated closely with designed depths, with deviations generally less than 0.5 mm; however, some instances showed deviations exceeding 2 mm, underscoring the need for careful interpretation. At temperatures above 230 °C, the disbanding of probe elements led to weak or absent signals, complicating data interpretation and requiring adjustments in testing protocols. This study highlights the feasibility and effectiveness of PACM for corrosion detection on hot SS surfaces, providing critical insights into material behavior under thermal conditions. Future research should include physical examination of samples using Scanning Electron Microscopy (SEM) to validate and enhance the reliability of the findings. The integration of non-contact NDT methods and optimization of calibration techniques are essential for improving PACM performance at elevated temperatures.
COVIDomics: Metabolomic Views on COVID-19
Authors: Cevenini Armando , Santorelli Lucia , Costanzo Michele
Published: December 2024

During the COVID-19 pandemic, omics-based methodologies were extensively used to study the pathological mechanisms of SARS-CoV-2 infection and replication in human cells at a large scale [...]
The Role of the Emeishan Large Igneous Province in Hydrocarbon Formation in the Anyue Gas Field, Sichuan Basin, China
Authors: Ni Zhiyong , Zhu Chuanqing , Liu Huichun , Yang Chengyu , Shao Ganggang , Zhang Wen , Luo Bing
Published: December 2024

This study investigates the impact of the Emeishan Large Igneous Province (ELIP) on hydrocarbon formation within the Anyue gas field in the Sichuan Basin. As a major Middle to Late Permian large igneous province, the ELIP hosted intense mantle plume activity that reshaped regional tectonics and thermal structures, indirectly influencing hydrocarbon accumulation. This paper examines three primary factors in hydrocarbon evolution linked to the ELIP: its thermal influence, induced fluid activity, and role in hydrocarbon cracking. Data reveal that the thermal effects of the ELIP extend to the central Sichuan Basin, where an elevated paleogeothermal gradient has driven hydrocarbon evolution in the Anyue gas field. Petrographic characteristics, chronological data, fluid inclusion features, and C–O, S, and Pb isotopic signatures collectively indicate that around 260 Ma, a hydrothermal event occurred in the Sichuan Basin, closely aligned with a natural gas charging event. The combined effects of a heightened geothermal gradient and hydrothermal fluids (with temperatures up to 320 °C) suggest that paleo-oil reservoirs had already cracked into natural gas during the peak ELIP activity.
Supply Chains Problem During Crises: A Data-Driven Approach
Authors: Salamian Farima , Paksaz Amirmohammad , Khalil Loo Behrooz , Mousapour Mamoudan Mobina , Aghsami Mohammad , Aghsami Amir
Published: December 2024

Efficient management of hospital evacuations and pharmaceutical supply chains is a critical challenge in modern healthcare, particularly during emergencies. This study addresses these challenges by proposing a novel bi-objective optimization framework. The model integrates a Mixed-Integer Linear Programming (MILP) approach with advanced machine learning techniques to simultaneously minimize total costs and maximize patient satisfaction. A key contribution is the incorporation of a Gated Recurrent Unit (GRU) neural network for accurate drug demand forecasting, enabling dynamic resource allocation in crisis scenarios. The model also accounts for two distinct patient destinations—receiving hospitals and temporary care centers (TCCs)—and includes a specialized pharmaceutical supply chain to prevent medicine shortages. To enhance system robustness, probabilistic demand patterns and disruption risks are considered, ensuring supply chain reliability. The solution methodology combines the Grasshopper Optimization Algorithm (GOA) and the ɛ-constraint method, efficiently addressing the multi-objective nature of the problem. Results demonstrate significant improvements in cost reduction, resource allocation, and service levels, highlighting the model’s practical applicability in real-world scenarios. This research provides valuable insights for optimizing healthcare logistics during critical events, contributing to both operational efficiency and patient welfare.
Silica Waveguide Thermo-Optic Mode Switch with Bimodal S-Bend
Authors: Yao Zhentao , Wang Manzhuo , Zhang Yue , Sun Zhaoyang , Sun Xiaoqiang , Wu Yuanda , Zhang Daming
Published: December 2024

A silica waveguide thermo-optic mode switch with small radius bimodal S-bends is demonstrated in this study. The cascaded multimode interference coupler is adopted to implement the E11 and E21 mode selective output. The beam propagation method is used in design optimization. Standard CMOS processing of ultraviolet photolithography, chemical vapor deposition, and plasma etching are adopted in fabrication. Detailed characterizations on the prepared switch are performed to confirm the precise fabrication. The measurement results show that within the wavelength range from 1530 to 1575 nm, for the E11 mode input, the switch exhibits an extinction ratio of ≥13.1 dB and a crosstalk ≤−22.8 dB at an electrical driving power of 284.8 mW, while for the E21 mode input, the extinction ratio is ≥15.5 dB and the crosstalk is ≤−18.1 dB at an electrical driving power of 282.4 mW. These results prove the feasibility of multimode S-bends in mode switching. The favorable performance of the demonstrated switch promises good potential for on-chip mode routing.
Highly Sensitive and Selective SnO2-Gr Sensor Photoactivated for Detection of Low NO2 Concentrations at Room Temperature
Authors: Sayago Isabel , Sánchez-Vicente Carlos , Santos José Pedro
Published: December 2024

Chemical nanosensors based on nanoparticles of tin dioxide and graphene-decorated tin dioxide were developed and characterized to detect low NO2 concentrations. Sensitive layers were prepared by the drop casting method. SEM/EDX analyses have been used to investigate the surface morphology and the elemental composition of the sensors. Photoactivation of the sensors allowed for detecting ultra-low NO2 concentrations (100 ppb) at room temperature. The sensors showed very good sensitivity and selectivity to NO2 with low cross-responses to the other pollutant gases tested (CO and CH4). The effect of humidity and the presence of graphene on sensor response were studied. Comparative studies revealed that graphene incorporation improved sensor performance. Detections in complex atmosphere (CO + NO2 or CH4 + NO2, in humid air) confirmed the high selectivity of the graphene sensor in near-real conditions. Thus, the responses were of 600%, 657% and 540% to NO2 (0.5 ppm), NO2 (0.5 ppm) + CO (5 ppm) and NO2 (0.5 ppm) + CH4 (10 ppm), respectively. In addition, the detection mechanisms were discussed and the possible redox equations that can change the sensor conductance were also considered.
The 2024 Nobel Prize in Physiology or Medicine: microRNA Takes Center Stage
Authors: Calin George A. , Hubé Florent , Ladomery Michael R. , Delihas Nicholas , Ferracin Manuela , Poliseno Laura , Agnelli Luca , Alahari Suresh K. , Yu Ai-Ming , Zhong Xiao-Bo
Published: December 2024

The Non-coding Journal Editorial Board Members would like to congratulate Victor Ambros and Gary Ruvkun, who were jointly awarded the 2024 Nobel Prize in Physiology or Medicine for their groundbreaking discovery of microRNAs and the role of microRNAs in post-transcriptional gene regulation, uncovering a previously unknown layer of gene control in eukaryotes [...]
Secured Real-Time Machine Communication Protocol
Authors: Ren Yifei , Rupasinghe Lakmal , Khaksar Siavash , Ferdosian Nasim , Murray Iain
Published: December 2024

In this paper, we introduce the Secured Real-Time Machine Communication Protocol (SRMCP), a novel industrial communication protocol designed to address the increasing demand for security and performance in Industry 4.0 environments. SRMCP integrates post-quantum cryptographic techniques, including the Kyber Key Encapsulation Mechanism (Kyber-KEM) and AES-GCM encryption, to ensure robust protection against both current and future cryptographic threats. We also present an innovative “Port Hopping” mechanism inspired by frequency hopping, enhancing security by distributing communication across multiple channels. Comparative performance analysis was conducted with widely-used protocols such as ModBus and the OPC UA, focusing on key metrics such as connection, reading, and writing times across local and remote networks. Results demonstrate that SRMCP outperforms ModBus in reading and writing operations while offering enhanced security, although it has a higher connection time due to its dual-layer encryption. The OPC UA, while secure, lags significantly in performance, making it less suitable for real-time applications. The findings suggest that SRMCP is a viable solution for secure and efficient machine communication in modern industrial settings, particularly where quantum-safe security is a concern.
Strategies for Effective Communication in Hypertension Management: Validation of Messages from a Mobile Application to Assist Hypertensive Older Adults in Adherence to Treatment, Nutrition and Physical Activity
Authors: Pereira Alayne , Trombini Raiza , Barbalho Yuri , Stival Marina , Lima Luciano , Zandonadi Renata , Ginani Verônica , Dusi Rafaella , Funghetto Silvana Schwerz
Published: December 2024

Background: Poor adherence to antihypertensive treatment is a common problem among elderly hypertensive patients and one of the leading causes of inadequate blood pressure control. In this sense, it is essential to improve strategies for effective communication in managing hypertension treatment for this group. Objective: This study aimed to validate the text messages of a mobile application to aid adherence to antihypertensive treatment, nutrition, and physical activity among older adults with hypertension treated in Brazilian public primary health care. Methods: This descriptive, methodological development study with a quantitative approach was carried out between March and August 2024. Results: A total of 27 messages were constructed and validated by 13 experts, and this stage was divided into two rounds. The Content Validity index and percentage of agreement were used in the validation process. The messages were developed using theory, national guidelines, validation, and expert review. Conclusions: Text messages for adherence to antihypertensive treatment involving medication, nutrition, and physical activity have enormous potential with the target audience studied.
Correction: Wang et al. Integration of Transcriptomics and Lipidomics Profiling to Reveal the Therapeutic Mechanism Underlying Ramulus mori (Sangzhi) Alkaloids for the Treatment of Liver Lipid Metabolic Disturbance in High-Fat-Diet/Streptozotocin-Induced Diabetic Mice. Nutrients 2023, 15, 3914
Authors: Wang Fan , Xu Sai-Jun , Ye Fan , Zhang Bin , Sun Xiao-Bo
Published: December 2024

In the original publication [...]
Biological Effect of Food for Special Medical Purposes (NutramilTM Complex) on Melanoma Cells in In Vitro Study
Authors: Koronowicz Aneta , Krawczyk Katarzyna , Such Aleksandra , Piasna-Słupecka Ewelina , Drozdowska Mariola , Leszczyńska Teresa
Published: December 2024

Background/Objectives: Melanoma malignum is considered the most dangerous form of skin cancer, characterized by the exceptional resistance to many conventional chemotherapies. The aim of this study was to evaluate the effect of NutramilTM Complex (NC)—Food for Special Medical Purpose (FSMP), on two types of melanoma cell lines, primary WM115 and malignant WM266-4. Methods: At 24 h after seeding, growth medium was replaced with a medium containing encoded treatments of NC or NC-CC (NutramilTM Complex without calcium caseinate) at various concentrations. Cells were treated for 24, 48, and 72 h. Results: Our results showed that NutramilTM Complex reduces proliferation of malignant melanoma WM266-4 cells but did not affect the proliferation of WM115 primary melanoma. This was followed by measured down-regulation of selected pro-survival proteins expression in WM266-4 cells, specifically ERK1/2, AKT-1, HSP27, Survivin, and TAK1. Interestingly, our results showed elevated levels of some pro-apoptotic proteins in both cell lines, including Bad, Smad2, p38MAPK, cleaved forms of Caspase-3/7, as well as cleaved PARP. Conclusions: Taken together, our results indicate that various melanoma cancer cell lines may respond in a different way to the same compound. They also suggest induction of apoptotic pathway by NutramilTM Complex as the most likely mechanism of its anticarcinogenic activity.
The Association Between Nutritional Risk and Bone Stiffness in Elderly Men and Women in a Population-Based Study in Northeast Germany
Authors: Riest Jannis , Friedrich Nele , Nauck Matthias , Völzke Henry , Gärtner Simone , Hannemann Anke
Published: December 2024

Background: The Geriatric Nutritional Risk Index (GNRI) has shown promising potential for identifying individuals at risk for osteoporosis in various patient cohorts. However, data from the general population confirming or refuting the usefulness of the GNRI as a risk factor for osteoporosis are sparse. We therefore aimed to clarify whether the GNRI is associated with the ultrasound-based bone stiffness index and the osteoporotic fracture risk in a sample of elderly men and women from the general population. Methods: Data from 1417 participants in the Study of Health in Pomerania START-2 or TREND-0 aged 65 years or older with quantitative ultrasound measurements at the heel and GNRI values were examined. In cross-sectional linear and logistic regression models, associations between the GNRI and heel stiffness index or ultrasound-based osteoporotic fracture risk were examined. All analyses were repeated after stratification of the study population according to BMI (underweight/normal weight, overweight and obese). Results: In underweight/normal weight individuals, higher, i.e., better, GNRI values had a positive effect on the stiffness index (β-coefficient per standard deviation increase in GNRI = 2.69, standard error = 1.00, p = 0.007). With increasing GNRI values, underweight/normal weight elderly men and women also had higher chances of a low osteoporotic fracture risk (odds ratio 1.42, 95% confidence interval 1.04–1.94, p = 0.026). Corresponding associations in overweight or obese individuals were absent. Conclusions: In elderly men and women with underweight/normal weight, the GNRI is positively associated with the bone stiffness index and the related osteoporotic fracture risk. In this group, the GNRI may prove useful in identifying individuals with an elevated fracture risk.
The Role of Maternal and Early-Life Diet in Inflammatory Bowel Disease
Authors: Karaivazoglou Katerina , Triantos Christos , Aggeletopoulou Ioanna
Published: December 2024

Background/Objectives: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder with debilitating symptoms and multifactorial etiology. Nutritional factors during adult life have been implicated in IBD pathogenesis. In addition, there is growing evidence that maternal and early-life diet may be associated with intestinal inflammation and colitis severity. The aim of the current review was to detect and critically appraise all evidence regarding the role of maternal and early-life diet on intestinal inflammation. Methods: We performed a thorough search of the literature across two databases (Pubmed, ScienceDirect) using a variety of relevant terms. Results: A total of 23 studies, 16 experimental and 7 clinical, met inclusion criteria and were included in this review. Experimental studies reveal that high-fat and high-protein diets during gestation and neonatal life induce gut dysbiosis, amplify intestinal inflammation, and exacerbate colitis. In addition, a variety of nutritional factors included in maternal diets may affect offspring’s microbiota composition and intestinal health. Human studies concluded that maternal diet quality and the intake of fish and vegetables and of food fortified with vitamin D during gestation and early infancy significantly decreased IBD risk. However, human data are limited, and larger investigations are needed to further clarify the complex associations between specific nutritional compounds and intestinal inflammation. Conclusions: Dietary factors during pregnancy and early-life are involved in IBD pathogenesis, exerting either an exacerbating or protective effect. Improving pregnant women’s dietary habits could be a cost-effective strategy to reduce future IBD burden.
Circadian Deregulation: Back Facing the Sun Toward Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Development
Authors: Verdelho Machado Mariana
Published: December 2024

Earth’s rotation around its axis has pressured its inhabitants to adapt to 24 h cycles of day and night. Humans adapted their own circadian rhythms to the Earth’s rhythms with a light-aligned awake–sleep cycle. As a consequence, metabolism undergoes drastic changes throughout the circadian cycle and needs plasticity to cope with opposing conditions in the day (when there is an increase in energy demands and food availability), and during the night (when prolonged fasting couples with cyclic changes in the energy demands across the sleep stages). In the last century, human behavior changed dramatically with a disregard for the natural circadian cycles. This misalignment in sleep and eating schedules strongly modulates the metabolism and energy homeostasis, favoring the development of obesity, metabolic syndrome, and metabolic dysfunction-associated steatotic liver disease (MASLD). This review summarizes the effects of circadian disruption, with a particular focus on the feeding and sleep cycles in the development of MASLD and hepatocellular carcinoma.