bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Video Pembelajaran Berbantuan Powtoon pada Mata Pelajaran IPA Siswa Kelas IV
Authors: Putra Putu Arik Fernanda , Tegeh I Made , Suwatra Ignatius I Wayan
Published: April 2023

Rendahnya hasil belajar siswa pada mata pelajaran IPA karena belum adanya media video pembelajaran yang menunjang proses pembelajaran pada mata pelajaran IPA. Penelitian ini bertujuan untuk menghasilkan rancang bangun video pembelajaran berbantuan powtoon dan mendeskripsikan kualitas hasil validasi pengembangan video pembelajaran berbantuan powtoon. Model yang digunakan dalam penelitian pengembangan ini menggunakan model ADDIE. Metode dalam mengumpulkan data adalah, 1) metode observasi, 2) metode wawancara, 3) metode pencatatan dokumen, dan 4) metode kuesioner. Penelitian ini bertujuan untuk mengembangkan rancang bangun video pembelajaran berbantuan powtoon dan mendeskripsikan kualitas hasil validasi pengembangan video pembelajaran berbantuan powtoon. Teknik analisis data yang digunakan adalah teknik analisis deskriptif kualitatif dan teknik analisis deskriptif kuantitatif. Hasil validitas produk video pembelajaran powtoon dikatakan valid dengan masing-masing penilaian, a) hasil review ahli isi pembelajaran dengan persentase 93% dengan kategori sangat baik, b) hasil review ahli desain pembelajaran dengan persentase 90% dengan kategori sangat baik, c) hasil review ahli media pembelajaran dengan persentase 93% dengan kategori baik, d) hasil uji coba perorangan dengan persentase 94,81% dengan kategori sangat baik, e) hasil uji coba kelompok kecil dengan persentase 94,66% dengan kategori sangat baik. Berdasarkan hasil penelitian, dapat disimpulkan bahwa pengembangan video pembelajaran powtoon ini layak dan dapat digunakan dalam proses pembelajaran.
Instrumen Penilaian Sikap Spiritual dan Sikap Sosial Siswa Kelas VI pada Tema Persatuan dalam Perbedaan
Authors: Anggreni Ni Kadek Ledi , Astawan I Gede , Rati Ni Wayan
Published: April 2023

Kurang maksimalnya penilaian pada ranah afektif disebabkan oleh tidak adanya pengembangan instrumen penilaian yang mampu mengukur aspek-aspek penilaian. Tujuan penelitian ini untuk menghasilkan instrumen penilaian sikap spiritual dan sikap sosial siswa kelas VI SD pada tema Persatuan dalam Perbedaan yang valid dan reliabel. Penelitian ini berjenis pengembangan dengan menggunakan model pengembangan RDR. Metode pengumpulan data berupa lembar validasi instrumen dengan melibatkan dua ahli dan dua praktisi kelas VI. Subjek penelitian ini adalah 2 orang ahli dan 2 orang praktisi kelas VI. Metode analisis data menggunakan uji gregory untuk mencari validitas dan uji percentage of agreement untuk mencari reliabilitas. Validitas isi instrumen penilaian sikap spiritual dan sikap sosial menunjukkan hasil 1,00 berkriteria validitas sangat tinggi. Reliabilitas pada instrumen sikap spiritual dan sikap sosial menunjukkan hasil 1,00 berkriteria reliabel. Dapat disimpulkan bahwa instrumen layak untuk digunakan menilai sikap spiritual dan sikap sosial siswa kelas VI SD pada tema Persatuan dalam Perbedaan.
Illustrated Electronic Module to Improve Elementary School Students' Creative Thinking Skills
Authors: Suantini I Gusti Ayu Ketut Ari , Antara Putu Aditya , Trisna Gusti Ayu Putu Sukma
Published: April 2023

Low learning outcomes are caused because students need to have the ability to think creatively. The findings state that students need help to express ideas or ideas in learning activities so that learning activities do not run optimally. This study aims to develop an electronic pictorial module to improve the creative thinking skills of fourth-grade elementary school students. This type of research is developed with the ADDIE model. The research subjects were two material expert lecturers, two media expert lecturers, and one practitioner. The test subjects totaled 26 students—data collection using the questionnaire method. The instrument used is the rating scale instrument. Data analysis techniques are qualitative descriptive statistical analysis, quantitative descriptive, and inferential statistics. The results of the research are media experts' assessment of 4.8 (very good), material experts’ 4.9 (very good), and practitioner results of 5 (very good). The results of the 2-way (2-tailed) significance value were 0.000 <0.05 so that there were differences in the results of the creative thinking abilities of fourth-grade elementary school students after learning to use pictorial electronic modules (e-modules). It was concluded that the pictorial E-Module effectively increases the results of creative thinking skills.
Analytical images of Kepler's equation solutions and their applications
Authors:   Ivan Franko National University of Lviv, Vavrukh M. , Dzikovskyi D. ,   Ivan Franko National University of Lviv, Stelmakh O. ,   Ivan Franko National University of Lviv
Published: April 2023

The simple fast-converging analytical calculations algorithms for eccentric anomaly are proposed for an arbitrary eccentricity 0<e≤1. The kinematic characteristics of Halley's comet are calculated as the function of time. Mass of Galaxy + NGC 224 system using the model of elliptical relative motion is also estimated.
Apiturizmin Geliştirilmesi Kapsamında Apirota Oluşturulmasına Yönelik Bir Araştırma: Marmaris Örneği
Authors: Ayaz Dönmez Nermin , Helvacıoğlu Fahri
Published: April 2023

Çalışmanın amacı, dinlence, deniz ve çeşitli alternatif turizm faaliyetlerinin gerçekleştiği Marmaris’in, kırsal alanında arıcılık faaliyetleri ile ziyaretçi çekmeyi sağlayacak ve bölgede değer yaratacak apirota önerisi oluşturmaktır. Araştırma, Eylül 2022 tarihinde gerçekleşmiştir. Araştırma alanı Marmaris’in Hisarönü Körfezi ile İçmeler Koyu arasında çizilecek hattın güneyinde kalan ve arıcılık faaliyetleri yapılan kırsaldır. Çalışmada, nitel araştırma yöntemi kullanılmıştır. Araştırma alanında, apiturizmi geliştirme ve apirota oluşturmaya yönelik görüşlerin toplanması için görüşme tekniğinden yararlanılmıştır. Görüşmelerde yarı yapılandırılmış toplam 7 açık uçlu soru sorulmuştur. Araştırma alanı ile ilgili derinlemesine bilgi sahibi olan yerel arıcı ve turizm profesyonellerinden oluşan 10 katılımcının görüşlerine başvurulmuştur. Araştırma sonucunda araştırma alanının, apiturizm arzına sahip olduğu; kırsaldaki kültürel, tarihi ve doğal zenginliklerin bu arzı zenginleştireceği; apiturizm kapsamında yapılabilecek uygulamaların ve ürünlerin çeşitlendirilmesi gerektiği ortaya koyulmuştur. Elde edilen veriler ışığında apiturizmin gelişimine katkı sağlayacağı düşünülen bir apirota geliştirilmiştir.
Impacto ambiental y riesgos potenciales generados en los rellenos Sanitarios – Revisión narrativa de la literatura
Authors: Cárdenas-Valbuena Rocio del Pilar , López-Quemba Germán Alberto , Talero-Moreno Deisy , Cely-Grijalba Andrea Paola , Murillo-Naranjo Liz Marivel , Velasco-Quiroga Grised Andrea , Contreras-Pacheco Fabiola
Published: April 2023

Introducción: El derecho a un medio ambiente sano posibilita a las personas a desarrollarse y vivir satisfactoriamente. Desafortunadamente la actividad humana ha impactado en el ambiente y no siempre en forma positiva, uno de los aspectos perjudiciales para el medio ambiente, es la generación de productos de desechos o residuos sólidos y el inadecuado manejo, tratamiento y disposición de los mismos. Objetivo: Caracterizar el impacto ambiental y riesgos potenciales generados en los rellenos sanitarios Metodología: Se realizó una revisión narrativa de la literatura referente a el impacto ambiental y riesgos potenciales en los rellenos sanitarios, obtenida en bases de datos como Ovid, Proquest, Scielo, ScienceDirect, Taylor & Francis, Google Scholar, Scopus, Redalyc y Pubmed. Desarrollo y Discusión: Los rellenos sanitarios demuestran riesgos potenciales de contingencias que afectan la salud, como enfermedades (respiratorias, cutáneas, gastrointestinales) y accidentes (cortaduras, pinchazos, quemaduras) y daños en el ambiente como sobrecalentamiento y contaminación atmosférica derivados de la inadecuada disposición de desechos. Entre los factores de riesgo se identifican, gases, lixiviados contaminados, material electrónico, olores, incendios, contaminación del agua subterránea por lixiviados, cambio climático global y el no cumplimiento de normas en la construcción de rellenos sanitarios. Conclusión: se advierte un impacto negativo para el medio ambiente y la salud de la población derivado de la inadecuada eliminación de desechos sólidos en los rellenos sanitarios.
Soret and Dufour Effects on Chemically Reacting and Viscous Dissipating Nanofluid Flowing Past a Moving Porous Plate in the Presence of a Heat Source/Sink
Authors: Aastha Aastha , Chand Khem
Published: April 2023

This study performed a numerical investigation of the Soret and Dufour effects on unsteady free convective chemically reacting nanofluid flowing past a vertically moving porous plate in the presence of viscous dissipation and a heat source/sink. The equations directing the flow are non-dimensionalised, modified to ordinary differential equations and emerging equations are resolved computationally by using the bvp4c function in MATLAB software. The results obtained from this analysis indicate that the resulting velocity of the nanofluid increases with increasing Grashof number, mass Grashof number and porosity parameter. An increase in the Dufour number increases the fluid temperature, whereas the concentration profile declines with the increase in the Schmidt number. It is also observed that the skin friction coefficient, Nusselt number and Sherwood number increase with increasing magnetic field parameter, Eckert number and Schmidt number, respectively. The present study reveals the impact of Soret and Dufour effects on heat and mass transfer rates in chemically reacting and viscous dissipating nanofluids.
Aspect-Based Sentiment Analysis of Hotels in Bali on Tripadvisor Using BERT Algorithm
Authors: Bimaputra Dimas Samodra , Sutoyo Edi
Published: April 2023

The covid pandemic that began in 2020 has caused enormous losses worldwide, including in Indonesia. Human-to-human contact is the source of the transmission of the covid virus, so the government urges people to maintain cleanliness when interacting. Bali is a popular destination for foreign and domestic visitors in Indonesia. Hospitality businesses in Bali unquestionably face a high risk of covid transmission; consequently, changes in hotel business processes are unavoidable; the implementation of new business processes can have a negative effect on business performance. In order to maintain Bali's reputation as the most popular tourist destination in Indonesia, the government must evaluate the performance of several hotel services that have implemented new business processes. The Aspect-Based Sentiment Analysis (ABSA) methodology can be utilized for performance evaluation. One of the finest algorithms for analyzing text, Bidirectional Encoder Representations from Transformer (BERT), is required for sentiment analysis. The data consists of textual customer evaluations of hotels in Bali that have implemented a new protocol or Standard Operational Procedure (SOP), retrieved from the Tripadvisor website. In the form of a number of evaluations of various aspects of the hotel, the research results can assist the government in analyzing the performance of hotels in Bali based on predetermined criteria.
THE EU ENVIRONMENTAL TAXATION INFLUENCE ON A SUSTAINABLE DEVELOPMENT
Authors:   National University of Life and Environmental Sciences of Ukraine, Lazaryshyna Inna , Nehoda Yuliia ,   National University of Life and Environmental Sciences of Ukraine, Oliinyk Larysa ,   National University of Life and Environmental Sciences of Ukraine
Published: April 2023

European policyand environmental taxation mayhave a significant impact on promoting sustain-able development in the whole world and Europein particular.Although, properly designed strategic plans and a set of wide policy measures should be shaped to meet national needs and capabilities.Sus-tainable development refers to a way of achieving economic growth and societal progress that meets the needs of the present generation without compromising the ability of future generations to meet their own needs. It recognizes that economic, social, and environmental considerations are interconnected and that sustainable development requires a balance between these three pillars. The 2030 Agenda forSustainable Developmentand its 17 Sustainable Development Goals (SDGs)adopted by the United Nations (UN) in September 2015, lay down as an intrinsic part of the European Commission’s work programme, are the roadmap for achieving a sustainable future. The framework for sustainable development embracespoverty reduction, zero hunger, good health, education, clean water, affordable and clean energy, decent work and economic growth, reduced inequalities, sustainable cities, responsible consumption, climate action, gender equality, life below water, life on land, peace, justice and strong institutions, partnerships for the goals. The European Green Dealandthe common agricultural policy (CAP), set ambitious goals for re-ducing greenhouse gas emissions and promoting renewable energy and circular economy practices.On the other hand, environmental taxation remains animportant tool for promoting a “green” future. Taxes on carbon emissions, for example, can incentivize companies and individuals to reduce their carbon foot-print and shift towards cleaner energy sources. Similarly, taxes on single-use plastics can discourage their use and promote more sustainable alternatives.Also, the revision of the Energy Taxation Directive (ETD) supports theEU's climate targets by ensuring that the taxation of motor and heating fuels and electricity in the EU reflects their impact on the environment and our health. Overall, the combination of well-thought and revised EUpolicies along withenvironmental taxation can create a more sustainable economic model. By incentivizing companies and individuals to adopt sustainable practices, and by setting ambitious tar-gets for reducing emissions and promoting sustainable development, European countries can help build amore sustainable future for generations to come
Circuito Actitudinal: un modelo para la evaluación de los estudiantes en los posgrados
Authors: Pedroza-González Edmundo , Yuren Camarena María
Published: April 2023

El Circuito Actitudinal es un modelo analítico generado para contribuir a la inclusión fundamentada de actitudes, habilidades y valores en los posgrados y servir de base para la evaluación de quienes aspiran a ingresar o están por egresar de esos programas. La contribución responde a la oportunidad de mejora en el manejo de dichos elementos, dado que: se mencionan profusa pero desatentamente, en los planes de estudio; se tiene una visión difusa de ellos por parte de autoridades y docentes; y se aprecia, en publicaciones especializadas, la evaluación preponderante de aspectos disciplinares, y se descuidan las actitudes, habilidades y valores. Nos abocamos a realizar un análisis teórico que proveyera los insumos conceptuales y operacionales de una síntesis que sirviera de base al modelo. El resultado fue el Circuito Actitudinal. El análisis de las actitudes se abordó considerando su dimensión intrapsíquica (con sus componentes cognitivo, afectivo y conativo) y la extrapsíquica (que radica en el objeto actitudinal). Para explorar las habilidades en los estudiantes se retomó el concepto de agencia, entendida como una acción intencionada. Para examinar los valores consideramos dos enfoques: el que lo considera preferencia y el que lo considera cualidad en los objetos externos. Al respecto adoptamos una posición dialéctica. El Circuito se operacionalizó en un cuestionario para indagar el estatus actitudinal, de habilidades y de valores en aspirantes a posgrados. La aplicación del cuestionario en su fase piloto mostró el cumplimiento del propósito del estudio.
Post Yeni Kamu Yönetimi Yaklaşımı Işığında Çin Kamu Yönetimi Reformları
Authors: MÜLAZIMOĞLU Maksud Emre , GÜNAL Cihan Necmi
Published: April 2023

Birçok ülkenin yönetim reformu kapsamında uygulamaya koyduğu yeni kamu yönetimi anlayışı başarılı olduğu kadar başarısız örnekleri de ihtiva etmektedir. Bilhassa 1990’lı yılların sonundan itibaren piyasa odaklı reformların yol açtığı sorunlar nedeniyle tartışılmaya başlanan yeni kamu yönetimi, çeşitli reform girişimleri ile yenilenmeye çalışılmaktadır. Bu çabayı ifade eden çatı kavram ise post yeni kamu yönetimidir. Çalışmada, post yeni kamu yönetiminin ve öngördüğü yönetim sisteminin Çin kamu yönetiminde nasıl tezahür ettiği sorusu temel araştırma gündemini oluşturmaktadır. Bu bağlamda çalışmanın amacı ise geleneksel ve yeni kamu yönetimi anlayışları ile post yeni kamu yönetimi kavramını teorik kapsamda inceleyerek, Çin kamu yönetiminin 2000 yılından bu yana gerçekleştirdiği reformları kamu yönetimi yaklaşımları ekseninde analiz etmektir. Çalışmada post yeni kamu yönetimini reformlarını karakterize eden iki ana kategoriye, kurumsal-yapısal ve değer odaklı yönetim reformu, ulaşılmaktadır. Bu kategorilerden hareketle 2000 yılı itibariyle Çin kamu yönetiminde cereyan eden yönetim reformları post yeni kamu yönetimi anlayışı ekseninde çeşitli dokümanlar içerik analizi yoluyla irdelenmektedir. Buna göre kurumsal ve yapısal yönetim reformları çerçevesinde melez bir reform planı ortaya koyan Çin yönetimi, özellikle ilgili reformların inşasında kendine özgü siyasal-yönetsel değerlerden etkin bir şekilde yararlanarak post yeni kamu yönetimi yaklaşımına örnekler sunmaktadır.
Denetim ücreti ile denetim komitesinin karakteristikleri arasındaki ilişki: Borsa İstanbul örneği
Authors: TERZİ Serkan , KIYMETLİ ŞEN İlker
Published: April 2023

Bu çalışmada Borsa İstanbul’da işlem gören şirketlerin açıkladığı denetim ücreti ile denetim komitesinin karakteristikleri arasındaki ilişki incelenmiştir. Çalışmada denetim komitesinin karakteristikleri olaraktoplam üye sayısı, kadın üye sayısı, bağımsız üye sayısı, üyelerin uzmanlıkları, eğitim düzeyleri ve yapılan toplantı sayısı kullanılmıştır. Bu amaçla Borsa İstanbul’da 2020 ve 2021 yıllarında işlem gören 205 şirket analize dahil edilmiştir. Çalışmada çoklu doğrusal regresyon analizi kullanılmıştır. Yapılan çalışmada denetim ücreti ile denetim komitesinde iktisadi ve idaribilimler alanında eğitim gören kadın üyeler arasında anlamlı ve pozitif ilişki tespit edilmiştir. Bunun yanında diğer hipotezler reddedilmiştir. Ayrıca şirketin büyüklüğüvebağımsız denetçi ile denetim ücreti arasında anlamlı ve pozitif ilişki tespit edilmiştir.
Investigating the Involvement of Cytokines and Neurotrophic Factors in the Advanced Stages of Huntington’s Disease: A BACHD Study
Authors:   Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte –MG, Brazil, Valadão Priscila Aparecida Costa , Oliveira Bruna da Silva ,   Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte –MG, Brazil, Machado Caroline Amaral ,   Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte –MG, Brazil, Fernandes Heliana de Barros ,   Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte –MG, Brazil, Machado Thatiane Cristina ,   Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte –MG, Brazil, Soares Kívia Santos ,   Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte –MG, Brazil, Teixeira Antonio Lucio ,   Faculdade Santa Casa BH, Belo Horizonte, MG, Brazil, Guatimosim Cristina ,   Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte –MG, Brazil, Miranda Aline Silva de ,   Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte –MG, Brazil
Published: April 2023

Neuroinflammation seems to be involved in the pathophysiology of Huntington’s Disease (HD), but its specific role on different stages of the disease, especially in later stages, remains to be understood. Here in, we investigated the concentrations of cytokines, chemokines and neurotrophic factors in striatum and frontal cortex of 24-month-old BACHD mice, a murine model of that displays several behavioral and pathological features of human HD. Our results revealed increased concentrations of the chemokine MCP-1 and the neurotrophin NGF in the striatum of BACHD mice alongside a reduction in the levels of the cytokine IL-6 and of the neurotrophin BDNF. In the frontal cortex, we found decreased levels of BDNF and MCP-1. We provide the first evidence that cytokines and neurotrophic factors may contribute to the pathophysiology of advanced HD.
From Particle-in-a-Box Thought Experiment to a Complete Quantum Theory?
Authors: Chen Jixin
Published: April 2023

It is an unavoidable question raised by Albert Einstein if quantum theory is complete. The wavefunctions of elements are now constructed from fitting the experimental data which has made quantum chemistry a black box of mathematical model. It is our best interest to come up with a simpler model to fit the data regardless of our wish to understand reality in a more intuitive and accurate way than classical quantum mechanics. In this manuscript, I speculated that the energy density distributions along space and time in a quantum system are uniform according to the 1st law of thermodynamics. Thus, the complementary energy contributions are added to the classical solutions of the 1D particle in a box problem, making the energy density a complex distribution function over space and time. Then the concept is extended to the free rotation problem with a Hamiltonian slightly different than the classical Schrödinger equation. The picturized energy distribution functions and associated time evolution are described in movies for comparison between example classical wave functions and the energy density functions. The radial wavefunctions for the hydrogen atom and an ideal harmonic oscillator are then derived. Can this assumption on energy distribution and the pre-mature math in this manuscript lead to a complete quantum theory? Can the idea of energy conservation unify special relativity and quantum?
A sticky bacterium can overcome various antiadhesive surfaces
Authors: Yoshimoto Shogo , Ishii Satoshi , Kawashiri Ayane , Matsushita Taishi , Linke Dirk , Göttig Stephan , Kempf Volkhard , Takai Madoka , Hori Katsutoshi
Published: April 2023

While microorganisms have evolved to adhere and form biofilms on surfaces, many materials with antiadhesive surfaces have been developed. The gram-negative bacterium Acinetobacter sp. Tol 5 exhibits high adhesiveness to various surfaces of general materials, from hydrophobic plastics to hydrophilic glass and metals, via AtaA, an Acinetobacter trimeric autotransporter adhesin (TAA). Efficient antiadhesive surfaces should prevent even Tol 5 from adhering. Here, we examined the adhesion of Tol 5 and other bacteria expressing different TAAs to antiadhesive surfaces. The results highlighted the stickiness of Tol 5 through the action of AtaA, which enabled Tol 5 cells to adhere even to antiadhesive materials, including polytetrafluoroethylene with a low surface free energy, a hydrophilic polymer brush with steric hindrance, and mica with an ultrasmooth surface. Single-cell force spectroscopy as an atomic force microscopy technique revealed the strong cell adhesion force of Tol 5 to these antiadhesive materials. Nevertheless, Tol 5 cells showed a weak adhesion force toward a zwitterionic 2-methacryloyloxyethyl-phosphorylcholine (MPC) polymer-coated surface. Dynamic flow cell experiments revealed that Tol 5 cells, once attached to the MPC polymer-coated surface, were exfoliated by weak shear stress. The underlying adhesive mechanism was presumed to involve exchangeable, weakly bound water molecules, suggesting that a perfect antiadhesive surface needs a high free water fraction.
Computational Medicinal Chemistry applications to cure Asian-prevalent strain of Hepatitis C Virus
Authors: hussain rashid , Haider Zulkarnain , Khalid Hira , Fatmi M.Qaiser , Carradori Simone , Cataldi Amelia , Zara Susi
Published: April 2023

Hepatitis C Virus (HCV), affecting millions of people worldwide, is the leading cause of the liver disorder, cirrhosis, and hepatocellular carcinoma. HCV is genetically diverse having eight gen-otypes and several subtypes predominant in different regions of the globe. The HCV NS3/4A protease is a primary therapeutic target for HCV with various FDA-approved antivirals and several clinical developments. However, available protease inhibitors (PIs) have lower potency against HCV genotype 3 (GT3), prevalent in South Asia. In this study, the incumbent computational tools were utilized to understand and explore interactions of the HCV GT3 receptor with the potential inhibitors after the virtual screening of one million compounds retrieved from the ZINC database. The molecular dynamics, pharmacological studies, and experimental studies uncovered the potential PIs as ZINC000224449889, ZINC000224374291, and ZINC000224374456 and derivative of ZINC000224374456 from the ZINC library. The study revealed that these top hit compounds exhibited good binding and better pharmacokinetics properties that might be considered the most promising compound against HCV GT3 protease. Viability test, on primary healthy Human Gingival Fibroblasts (HGFs) and cancerous AGS cell line were also performed to assess their safety profile after administration. In addition, Surface Plasmon Resonance (SPR) was also performed for determination of affinity and kinetics of synthesized compounds with target proteins.
Concerted local and nonlocal effects on tip-enhanced nonlinear plasmonics
Authors: Takahashi Shota , Sakurai Atsunori , Mochizuki Tatsuto , Sugimoto Toshiki
Published: April 2023

We report critical impacts of local and nonlocal geometries of plasmonic tips on the broadband nonlinear optical responses in tip-substrate nanocavities. Using gold tips with varied geometries, we demonstrated for the first time that not only the nanometer-scale sharpness of tip apexes but also the micrometer-scale surface geometry of tip shafts directly affects the enhancement properties of second-harmonic generation over the visible-to-infrared wavelength range. Numerical simulations of plasmonic field in the tip-substrate nanocavities revealed concerted contributions from spatially nonlocal and local plasmonic modes. Micrometer-scale tip shafts enable the excitation of nonlocal plasmonic modes throughout the tip, enhancing near-to-mid-infrared incoming light. Subsequent radiation of visible-to-near-infrared second harmonics is predominantly boosted by localized plasmons at the nanogap. Based on the agreement between experiments and calculations, our results indicate the importance of nanometer- and micrometer-scale geometrical engineering of plasmonic tips and provide a firm basis for the understanding and fine manipulation of nonlinear optical phenomena in tip-substrate nanocavities.
On the role of charge transfer in many-body non-covalent interactions
Authors: Řezáč Jan , de la Lande Aurélien
Published: April 2023

Charge transfer is one of the mechanisms involved in non-covalent interactions. In molecular dimers, its contribution to pairwise interaction energies has been studied extensively using a variety of interaction energy decomposition schemes. In polar interactions such as hydrogen bonds, it can contribute ten or several tens of percent of the interaction energy. Less is known about its importance in higher-order interactions in many-body systems, mainly because of the lack of methods applicable to this problem. In this work, we extend our method for the quantification of the charge-transfer energy based on constrained DFT to many-body cases and apply it to model trimers extracted from molecular crystals. Our calculations show that charge transfer can account for a large fraction of the total three-body interaction energy. This also has implications for DFT calculations of many-body interactions in general as it is known that many DFT functionals struggle to describe charge-transfer effects correctly.
Paired Site Characterization in Aluminosilicate Zeolites through Limited Alkylammonium Stability
Authors: Abdelrahman Omar , Lawal Ajibola
Published: April 2023

The spatial distribution of tetrahedrally coordinated aluminum incorporated into a mordenite framework inverse framework zeolite was investigated through the proton site-selective probe chemistry of alkylamine Hofmann elimination. Protons associated with paired Al sites were exclusively exchanged with divalent cobalt, while isolated protons remained intact and readily quantified through Hofmann elimination of adsorbed alkylammonium species. Through a combination of temperature-programmed methods and spectroscopic characterization, the stability of the adsorbed alkylammonium was found to be crucial to the accurate estimation of isolated protons. Only alkylammonium species undergoing Hofmann elimination through a primary carbocation were found to exclusively probe isolated protons on the surface of cobalt-exchanged ZSM-5. More stable secondary and tertiary carbocations typically used in the characterization of acid sites, resulted in significant overestimates of protonic site densities. The result is contrary to purely protonic zeolites, where alkylammonium stability is inconsequential to the quantification of the acid sites they are coordinated with. Consequently, n-propylamine was found to be a suitable reactive probe molecule for the quantification of isolated protonic sites on divalent metal-cation zeolite surfaces, forming n-propylammonium upon adsorption. Ensuring accurate probing of isolated protons on the surface of metal cation exchanged zeolites was also demonstrated to require control of ion-exchange conditions and sufficient extent of zeolite exposure to the adsorbing n-propylamine. The fraction of paired Al sites in ZSM-5 was measured to systematically increase with Al content, ranging between 6 and 63 % across a Si/Al of 140 and 11.5, respectively. Experimentally measured Al pairing was in excellent quantitative agreement with a binomial distribution, suggesting a random incorporation of Al into the tetrahedral sites of ZSM-5 at next-nearest-neighboring positions.
How do NMR coupling constants correlate with σ-donation in NHCs and their derivatives?
Authors: Gupta Radhika , Frison Gilles
Published: April 2023

Is 1JC-H coupling constant for protonated carbene a relevant measure of its s-donation ability? This paper investigates this assertion by comparing the calculated 1JC-H values for N-heterocyclic carbenes and their derivatives to other approaches such as HEP and ETS-NOCV methods. The obtained correlations are significantly better for similar compounds.
له‌ یادكردنه‌وه‌وه‌ بۆ نوسینه‌وه‌ی مێژوو‌ له‌ كولتوریی ئیسلامیدا
Authors: Azeez Hoshmand , Lashkry Haidar
Published: April 2023

ئه‌م توێژینه‌وه‌یه‌ باس له‌ بایه‌خ و گرنگی یاده‌وه‌ری و گێڕانه‌وه‌ی زاره‌كی له‌ناوكۆی كولتوریی ئیسلامیدا ده‌كات، له‌ هه‌نگاونان به‌ره‌و نوسین و دروستكردن و دانانی بناغه‌یه‌كی زانستی بۆ یاداشتكردن، ئه‌مه‌ش واتا په‌ڕینه‌وه‌ له‌ پڕۆسه‌ی گێڕانه‌وه‌ی زاره‌كی له‌ ڕێگای یاده‌وه‌رییه‌وه‌ بۆ مێژووی نوسراو، له‌ كولتوری عه‌ره‌بی پێش ئیسلام و سه‌رده‌می ئیسلامدا. گێڕانه‌وه‌ی زاره‌كی سه‌رچاوه‌یه‌كی سه‌ره‌كی نوسینی مێژووه‌، له‌ ڕێگای گێڕانه‌وه‌ی زاره‌كییه‌وه‌ ڕووداو و زانیارییه‌كان له‌ یاده‌وه‌ری نه‌وه‌كاندا‌ ده‌پارێزرێن، به‌مه‌ش یاده‌وه‌ری نوێنه‌رایه‌تی یه‌كێك له‌ سه‌رچاوه‌ گرنگه‌كانی ناو شێوازی نوسینی مێژوویی عه‌ره‌بی ئیسلامی كردووه‌ و ڕۆڵی به‌رچاو و هه‌ستیاری هه‌بووه‌ له‌ پاراستنی ڕووداوه‌كانی ڕابردوو و نواندنیان له‌ ئێستادا. هه‌روه‌ها خستنه‌ ڕووی هه‌نگاوه‌كانی نوسینه‌وه‌ی مێژوو به ‌تایبه‌ت له‌ ڕۆژگاری كولتوری عه‌ره‌بی ئیسلامیدا له‌ ڕێگای یاده‌وه‌ری و گێڕانه‌وه‌ زاره‌كییه‌كانه‌وه‌، كه‌ شرۆڤه‌ی قورئان و گێڕانه‌وه‌ی ڕووداوه‌كانی پێش هاتنه‌ خواره‌وه‌ی ئایه‌ته‌كان، فه‌رمووده‌، ژیاننامه‌ و جه‌نگه‌كانی پێغه‌مبه‌ر، دواتر ڕووداو و گرفته‌ نێوخۆییه‌كان و وڵاتگیرییه‌كانی له‌خۆگرتووه‌.
SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress
Authors: Yang Xue , Chung Jin-Yong , Rai Usha , Esumi Noriko
Published: April 2023

Retinal pigment epithelium (RPE) is essential for the survival of retinal photoreceptors. To study retinal degeneration, sodium iodate (NaIO3) has been used to cause oxidative stress-induced RPE death followed by photoreceptor degeneration. However, analyses of RPE damage itself are still limited. Here, we characterized NaIO3-induced RPE damage, which was divided into three regions: periphery with normal-shaped RPE, transitional zone with elongated cells, and center with severely damaged or lost RPE. Elongated cells in the transitional zone exhibited molecular characteristics of epithelial–mesenchymal transition. Central RPE was more susceptible to stresses than peripheral RPE. Under stresses, SIRT6, an NAD+-dependent protein deacylase, rapidly translocated from the nucleus to the cytoplasm and colocalized with stress granule factor G3BP1, leading to nuclear SIRT6 depletion. To overcome this SIRT6 depletion, SIRT6 overexpression was induced in the nucleus in transgenic mice, which protected RPE from NaIO3and partially preserved catalase expression. These results demonstrate topological differences of mouse RPE and warrant further exploring SIRT6 as a potential target for protecting RPE from oxidative stress-induced damage.
Coseismic chemical hydrogeodynamics of the Kultuk groundwater reservoir: indicator roles of the Na/Li, 234U/238U, and 234U
Authors:   Institute of the Earth's Crust SB RAS, Chebykin E.P. ,   Liminological Institute, SB RAS, Chuvashova I.S ,   Institute of the Earth's Crust SB RAS,   Irkutsk State Universit
Published: April 2023

Within the framework of the complete seismogeodynamic cycle of the central part of the Baikal Rift System, in the series of hydrogeochemical data obtained in 2012–2022 at stations of the Kultuk polygon, variations of the thermophilic elements Na and Li and Na/Li ratios are traced in connection with changes in the 234U/238U activity ratios and 234U activity, reflecting the opening and closing of microcracks for circulating groundwaters. Coseismic chemical hydrogeodynamics of the Kultuk groundwater reservoir is considered in terms of temperature and extension–compression of the crust.
On the causes and consequences of two devastating earthquakes in the Türkiye on February 6, 2023
Authors:   Institute of the Earth's Crust, SB RAS, Ruzhich V.V. , Berzhinskaya L.P. ,   Institute of the Earth's Crust, SB RAS,   Irkutsk National Research Technical University, Levina E.A. ,   Institute of the Earth's Crust, SB RAS, Ponomareva E.I. ,   Institute of the Earth's Crust, SB RAS
Published: April 2023

Using the developed geoinformation system “Prediction”, an analysis was made of information available from the media on two devastating earthquakes in the Türkiye that occurred in the western segment of the East Anatolian fault on February 6, 2023. The possibilities of recognizing signs of the preparation of earthquake data by means of medium-term forecasting developed for the Baikal rift zone, which are important for assessing seismic hazard and seismic risk, are discussed. Based on the analysis of the consequences of the large-scale destruction of residential and industrial infrastructure in the Türkiye, the causes of the huge damage to the country's economy caused by earthquakes, which are largely due to unfavorable seismotectonic conditions and urbanization problems that arose as a result of insufficient compliance with the necessary requirements and norms of earthquake-resistant construction, are considered.
Operational assessment of the consequences of the devastating earthquake in Turkey (according to the official published data of the media and the global network)
Authors:   Eurasian SEISMO Association, Akbiev R.T ,   Central Institute for Research and Design of the Ministry of Construction, Abakanov M.S. ,   Eurasian SEISMO Association
Published: April 2023

In this article, based on the analysis of the seismotectonic and seismological situation, an assessment of the consequences of the earthquake in Turkey is carried out. Geotectonic processes in the region, the largest earthquakes in the recent history of Turkey are considered. A comparative analysis of the standards for earthquake-resistant construction in Turkey, Russia and the CIS countries was carried out.
Adropin and risk factors of arterial hypertension in patients with excess body weight and obesity
Authors: Pokrovska Nataliia , Sklyarov Eugen
Published: April 2023

Introduction. Adropin is a hormone that is involved in the pathogenesis of arterial hypertension (AH) and diseases of the cardiovascular system and energy homeostasis, in particular, it reduces insulin resistance by controlling glucose synthesis in the liver. Aim. To investigate the level of adropin and its interaction with risk factors for AH in overweight and obese patients. Materials and methods. 70 patients with AH and overweight or obesity aged 62.4 ± 10.4 years were examined. 10 practically healthy people were selected for the control group. The level of adropin was determined by enzyme immunoassay (Finetest Elisa Kit) in blood serum. The inclusion criteria for participation in the study were: age of patients 40–75 years; arterial hypertension; BMI > 25 kg/m2. Results. It was established that the average level of adropin in patients with AH and comorbid obesity or excess body weight (n = 70) was 775.5 ± 311.7 pg/ml, which is significantly lower than the content of this peptide in practically healthy individuals (n = 10), which was 1084.6 ± 110.2 pg/ml (p < 0.01). A tendency towards a decrease in the level of the hormone in men was noted. It is probably associated with a much higher prevalence of smoking among this category of people, since when assessing the factors contributing to the development of AH and worsening its prognosis, a significant decrease in adropin was found in persons with a history of smoking (p < 0.01). In obese patients (BMI > 30 kg/m2), the level of adropin was significantly lower (p < 0.05), as well as in individuals with blood pressure > 150/90 mm Hg (p > 0.05). Conclusions. The level of serum adropin is significantly reduced in persons with AH and overweight and obesity compared to practically healthy persons. Factors contributing to a decrease in peptide concentration include smoking, obesity, and elevated blood glucose levels. Blood pressure indicators are not critical for changes in blood hormone concentration, which is probably due to medications used to treat AH.
El Fondo Rotatorio para el acceso a las vacunas de la Organización Panamericana de la Salud: 43 años respondiendo al programa regional de inmunizaciones
Authors: Cornejo Santiago , Chevez Ana , Ozturk Murat , Vargas Oscar , Behrensen Florencia , Solano Luisa , Rodriguez Daniel
Published: April 2023

El Fondo Rotatorio para el acceso a las vacunas (FR) de la Organización Panamericana de la Salud es un fondo común de capital y compra mancomunada de vacunas, jeringas y equipo de cadena de frío para los Estados Miembros de la Organización. Con el objetivo de evaluar los resultados obtenidos durante su funcionamiento y analizar su contribución a los logros de inmunización, se llevó a cabo una revisión de documentos históricos y literatura gris relacionados con la historia del FR, y se revisaron los procesos actuales, los datos de plataformas alimentadas por los informes anuales de los países, los indicadores de crecimiento, la carga de enfermedades prevenibles por vacunación, la introducción de nuevas vacunas en la Región de las Américas, y lecciones aprendidas. Se encontró que, en sus 43 años de funcionamiento, el FR ha crecido y ha contribuido a la introducción de nuevas vacunas, y que la Región ha avanzado de manera acelerada en el ámbito de las inmunizaciones. Sin embargo, varios países y territorios de la Región todavía no han introducido ciertas vacunas debido a sus altos precios y al impacto económico del mantenimiento de su administración. La cláusula del precio más bajo posible y del precio uniforme para todos los Estados Miembros participantes ha sido fundamental para la contribución del FR a las metas de vacunación de los programas nacionales de inmunización, así como para la planeación oportuna de la demanda acompañada por la asesoría técnica. El abordaje interprogramático y la planeación de insumos auxiliares son necesarios para el éxito de los programas. La preparación ante pandemias, la producción regional de vacunas y la protección de presupuestos nacionales para la compra de vacunas de alto costo y su sostenibilidad constituyen aún retos en el presente y el futuro.
Artificial Intelligence Education in Primary and Secondary Schools from the Perspective of Thinking Quality
Authors: Peng Min , Xie Jingming , Xiong Maohua , Liu Yunxiang
Published: April 2023

With the vigorous development of social economy in China, various advanced technologies and equipment have emerged, among which artificial intelligence (AI) has rapidly developed and achieved remarkable results when applied to many fields. Therefore, leaders and teachers in primary and secondary schools should pay more attention to AI education and explore effective measures to optimize the effectiveness of this education. Among them, carrying out artificial intelligence education and teaching from the perspective of thinking quality, with an aim to improve students’ technical ability and effectively cultivate their thinking skills, may improve students’ learning efficiency and teachers’ teaching efficiency. How to carry out AI education from the perspective of thinking quality is an important issue that teachers need to address urgently. Through in-depth research, we focus on this issue, in hope to benefit primary and secondary school teachers.
Gdyby Greimas czytał „Tytusa”
Authors:   Uniwersytet Jagielloński, Lisowska-Magdziarz Małgorzata
Published: April 2023

Artykuł jest próbą analizy wybranych elementów z komiksów Henryka Chmielewskiego o Tytusie, Romku i A’Tomku przy pomocy kwadratu semiotycznego i werydykcyjnego Algirdasa Greimasa. Kwadraty, użyte jako poręczne narzędzia analityczne o dużej i łatwo osiągalnej mocy eksplikacyjnej, służą tu do ujawnienia wewnętrznie dwuznacznej, wywrotowej natury komiksu.
KARS MÜZESİ’NDE BULUNAN OSMANLI DÖNEMİNE AİT BİR GRUP MÜHÜR
Authors: ÇABAZ Murat
Published: April 2023

Mühür insanoğlunun duvarlara, toprağa, kayalara resimler çizmesi, damgalarını vurması ile günümüze kadar gelişimini tamamlayan bir sanat olmuştur. Mühür, oluşum sürecinde farklı sanat dallarından etkilenerek, el sanatları ürünleri arasında önemli bir yer tutmuştur. Etkilendiği toplumun gerek dini, sosyal anlayışı gerekse de kullanılan malzemenin niteliğine göre toplumun iktisadi yapısını da göstermede büyük bir rolü vardır. Bu bağlamda bu çalışmayla Osmanlı dönemine ait bir grup mühür ele alınarak, sanat tarihi perspektifiyle pek çok açıdan detaylı bir şekilde analiz edilmeye çalışılmıştır. Çalışmaya dahil edilen mühürler, kullanım amaçlarına göre farklı gruplara ayrıldıkları tespit edilmiştir. Bu durum çalışmanın hedef ve amaçları açısından zengin bir veri sağlamaktadır. Dolayısıyla diğer sanat dallarında olduğu gibi, Osmanlıların son dönemine ait bu çalışmadaki mühürler, ait oldukları dönemi birçok açıdan aydınlatması hedeflenmiştir. Araştırmaya konu edinilen mühürler malzeme, form ve üzerlerinde kullanılan yazı gibi hususular göz önüne alınarak, mümkün mertebede birbirinden farklı örnekler seçilmiştir. Böyle bir yönteme başvurulmasında, ele alınan eserleri bir bütün olarak tüm yönleriyle değerlendirilebilmesini sağlamaktır. Bu amaçla Kars Müzesi’nde bulunan bir grup mühür, tüm yönleriyle analiz edilerek belgelendirilmiştir.
Actividades comunicativas para trabajar con películas cubanas
Authors: Simón Yessy Villavicencio , Melian Ivan Gabriel Grajales
Published: April 2023

El objetivo del estudio es demostrar la importancia de integrar algunas películas cubanas en el proceso de enseñanza-aprendizaje del nivel de referencia C1 de la disciplina Práctica Integral del Español como Lengua Extranjera en el Centro de Idiomas de la Facultad de Lenguas Extranjeras en la Universidad de Oriente, Cuba. Las especificidades de estos materiales audiovisuales los convierten en recursos motivadores para los usuarios de la lengua, pues facilitan contextualizar el componente pragmático. Se realiza un estudio de revisión bibliográfica de tipo cualitativa y exploratoria. Se aplicó la observación de las clases con estudiantes del nivel C1. Proponemos actividades comunicativas encaminadas al desarrollo de la competencia pragmática, a partir de las potencialidades del uso de la película cubana Habana Blues (2005). A modo de conclusión, reconocemos que la inclusión del cine como un recurso didáctico útil contribuye a potenciar la competencia pragmática en el alumnado no hispanohablante.
Çizgi Filmlerin İlettikleri Etik Değerler Bakımından İncelenmesi: Doru Örneği
Authors: YARDIMCIEL Fırat , KILIÇ Durmuş
Published: April 2023

Toplumların geleceğini yönlendiren çocukların ulusal ve evrensel değerleri özümseyerek, iyi bir şekilde eğitilmesi dijitalleşen çağımızda önem arz etmektedir. Davranışlarımıza kaynaklık eden değerlerin çocuklara doğru bir şekilde verilmesi, çocukların okudukları, izledikleri ve gördüklerinin düzenlenmesi ile mümkündür. Bu araştırmanın amacı temel eğitim dönemine yönelik olan çizgi filmler ile değer aktarımının önemini ortaya koymak ve Doru çizgi filmi örneği üzerinden verilen değerleri belirlemektir. Çalışma nitel araştırma yöntemi ile gerçekleştirilmiştir. Araştırmada 45 bölümden oluşan Doru çizgi filminin 26 bölümlük senaryosuna ilişkin elde edilen dokümanlar içerik analiziyle incelenmiştir. İlköğretim Sosyal Bilgiler Ders Programında yer verilen değerlerin içinden seçilen 18 değer incelemeye alınmıştır. Yapılan incelemeler sonucu Doru çizgi filminde incelenen 26 bölümde toplam 259 değer tespit edilmiştir.
Archetypal Nature Image in the Works of Maria Luisa Bombal
Authors: YETİM Arzu , DEMİR Berrin
Published: April 2023

An archetype is a prototype of patterns or behaviors recurring during history. Those images transmit the cultural phenomenon from one generation to another. And the archetypal relation between nature and woman goes back to the very early days of the universe, and is interrelated to the myth of “The Great Mother” as shown by Erich Neumann. Nature has opposite functions: life-giving and devastating. Those characteristics of nature are detailed and exemplified by Camille Paglia in Sexual Personae, Art and Decadence from Nefertiti to Emily Dickinson as well. That interrelatedness can be traced in the elements of the literature such as character, theme, place or space. In the works to be analyzed, the “nature” archetype is traced through a “tree” as a motif and the protagonist as a character. The study aims to discuss the archetypal “nature” image in Maria Luisa Bombal’s short stories “The Tree” (El árbol) and “Braids” (Trenzas) with a Pagliaesk approach. Bombal is one of the distinguished Chilean authors of XX. Century and the dual structure of nature is strongly stressed in the works of the writer, particularly with a “tree” and a “female character”. Those characters are alive with nature and hold on to life, but they cannot breathe (both literally and really) when nature fades away.
Sovereignty vs. Foreign Aid and Inducements
Authors: Wadehra Sunidhi
Published: April 2023

This paper posits that the processes and power asymmetries within inducements and foreign aid necessitate infringement on the receiving state’s sovereignty. However, the establishment of the statement requires careful individual analysis of the relevant topics, the examination of the intersection of the two subjects, and the exploration of pertinent examples. Firstly, this paper will analyze the individual concepts of sovereignty and the relevant economic statecraft, respectively. Secondly, this paper will examine the argument that the intersection of the topics reveals. Lastly, this paper will discuss two case studies: the United States’ inducement to North Korea in attempts to reduce their nuclear weapons capabilities and the United States’ foreign aid towards Soviet Russia in attempts to influence communist thought.