bluuebunny/crossref_metadata_2025 huggingface dataset:
Adjuvant Targeted Therapy in Solid Cancers: Pioneers and New Glories
Authors: Sposito Marco , Belluomini Lorenzo , Pontolillo Letizia , Tregnago Daniela , Trestini Ilaria , Insolda Jessica , Avancini Alice , Milella Michele , Bria Emilio , Carbognin Luisa , Pilotto Sara
Published: September 2023

Targeted therapy (TT) has revolutionized cancer treatment, successfully applied in various settings. Adjuvant TT in resected early-stage gastrointestinal stromal tumors (GIST), melanoma, non-small cell lung cancer (NSCLC), and breast cancer has led to practice-changing achievements. In particular, standard treatments include BRAF inhibitors for melanoma, osimertinib for NSCLC, hormone therapy or HER2 TT for breast cancer, and imatinib for GIST. Despite the undeniable benefit derived from adjuvant TT, the optimal duration of TT and the appropriate managing of the relapse remain open questions. Furthermore, neoadjuvant TT is emerging as valuable, particularly in breast cancer, and ongoing studies evaluate TT in the perioperative setting for early-stage NSCLC. In this review, we aim to collect and describe the large amount of data available in the literature about adjuvant TT across different histologies, focusing on epidemiology, major advances, and future directions.
Long-Term Outcomes of Liver Transplantation for the Management of Neuroendocrine Neoplasms: A Systematic Review
Authors: Palaniappan Varun , Li Chun , Frilling Andrea , Clift Ashley
Published: September 2023

Liver transplantation is an uncommonly used, controversially debated therapeutic approach for highly selected individuals with neuroendocrine liver metastases. Synthesising evidence regarding outcomes from this approach is crucial to understand its position within the broad neuroendocrine liver metastases armamentarium. In this narrative systematic review of studies published in PubMed, Scopus and OVID until 1 July 2021, we summarise and critically appraise the existing literature regarding this modality, with a special focus on long-term outcomes data where possible. Fourteen studies were identified that reported outcomes from the use of liver transplantation for metastatic neuroendocrine neoplasms. No randomised trials were identified. Generally, indications and selection criteria were poorly articulated, with the notable exception of studies using the Milan criteria. The median 5-year overall survival was 65% (ranging from 36% to 97.2%, 11 studies), and the median 10-year overall survival was 50% (ranging from 46.1% to 88.8%, 3 studies). One additional study focussed on treatments and outcomes following post-transplant recurrence. No studies reported outcomes past 10 years. Further follow-up of the largest series with explicit selection criteria will deepen our understanding of the role that transplantation has to play in this setting.
Evaluation of the Efficacy of Pectoral Nerve-2 Block (PECS 2) in Breast Cancer Surgery
Authors: Cylwik Jolanta , Celińska-Spodar Małgorzata , Buda Natalia
Published: September 2023

This study aimed to evaluate the efficacy of the pectoral nerves interfacial plane block (PECS II) in breast cancer surgery focusing on postoperative pain management and patient satisfaction. A prospective study was conducted, including 200 patients scheduled for breast cancer surgery. The participants were randomly assigned to the PECS II block and control groups. The PECS II block group received a preoperative interfascial plane block, while the control group received standard analgesia. Postoperative pain scores at 4 h intervals for the first 3 postoperative days, as well as opioid consumption and patient-reported satisfaction, were measured and compared between both groups. The PECS II block group demonstrated significantly lower postoperative pain scores at all measured time points (p < 0.001). Additionally, the PECS II block group showed reduced opioid consumption (p < 0.001), reported higher levels of patient satisfaction compared to the control group, and had a notably shorter stay in the postoperative care unit (p < 0.001). Integrating the PECS block with general anesthesia in breast cancer surgeries enhances pain management, reduces opioid use, and shorten postanesthesia care unit stay. The evident benefits suggest PECS as a potential standard in breast surgeries. Future research should further investigate its long-term impacts and broader applications.
Shielding the Nerve: A Systematic Review of Nerve Wrapping to Prevent Adhesions in the Rat Sciatic Nerve Model
Authors: Mayrhofer-Schmid Maximilian , Klemm Tess T. , Aman Martin , Kneser Ulrich , Eberlin Kyle R. , Harhaus Leila , Boecker Arne H.
Published: September 2023

Background: Peripheral nerve pathology is frequently encountered in clinical practice among peripheral nerve and extremity surgeons. One major factor limiting nerve regeneration and possibly leading to revision surgeries is the development of traumatic or postoperative adhesions and scarring around nerves. In experimental models, different materials have been studied to limit scar tissue formation when wrapped around nerves. Methods: A systematic review of studies describing nerve-wrapping materials in a non-transectional rat sciatic nerve model was performed following the PRISMA guidelines. Literature describing nerve-wrapping methods for the prevention of peripheral nerve scarring in rat sciatic nerve models was identified using PubMed and Web of Science, scanned for relevance and analyzed. Results: A total of 15 original articles describing 23 different materials or material combinations for nerve wrapping were included. The heterogeneity of the methods used did not allow a meta-analysis, thus, a systematic review was performed. Out of 28 intervention groups, 21 demonstrated a preventive effect on scar tissue formation in at least one qualitative or quantitative assessment method. Conclusions: The analyzed literature describes a variety of materials from different origins to limit peripheral nerve scarring and adhesions. Thus, a scar-preventive effect by wrapping peripheral nerves as adhesion prophylaxis seems likely. However, a quantitative comparison of the studies to identify the optimal material or technique is not possible with the diversity of used models and study designs. Therefore, further research needs to be performed to identify the optimal nerve wraps to be used routinely in clinical practice.
The Financial Impact of State Tax Regimes on Local Economies in the U.S.
Authors: Chairassamee Nattanicha , Hean Oudom , Jabas Parker
Published: September 2023

We examine the complex relationship between taxes and local economies at the county level. Specifically, we explore the impacts of different types of state-level taxes, including income and payroll taxes, property and other taxes, as well as sales tax, on key economic performance indicators. Our study aims to comprehensively analyze how state-level taxation influences entrepreneurship, innovation, labor markets, and overall economic growth in local communities. The findings consistently demonstrate that taxes harm local economies, although the magnitude of the impact varies depending on the specific type of tax. Notably, a 10 percent increase in income and payroll taxes leads to a 3 percent drop in the nonfarm proprietors employment rate, 0.3 fewer patents per 1000 people, and a USD 3000 decrease in GDP per capita. A similar tax hike in sales taxes results in a 4.5 percent decline in the nonfarm employment rate and a 0.2 patent reduction per 1000 people. Property and other taxes also harm the economy: a 10 percent increase is linked to a 5.3 percent fall in the nonfarm proprietors employment rate, a 7.5 percent rise in local unemployment, and a USD 55,000 drop in regional GDP per capita.
Editorial on the Volume “ESG Investing and ESG Finance”
Authors: Rachev Svetlozar (Zari) , Lindquist W. Brent
Published: September 2023

In the ever-evolving world of finance, ESG (Environmental, Social, and Governance) investing and finance have emerged as pivotal areas of study [...]
An Online Method for Supporting and Monitoring Repetitive Physical Activities Based on Restricted Boltzmann Machines
Authors: Alencar Marcio , Barreto Raimundo , Souto Eduardo , Oliveira Horacio
Published: September 2023

Human activity recognition has been widely used to monitor users during physical activities. By embedding a pre-trained model into wearable devices with an inertial measurement unit, it is possible to identify the activity being executed, count steps and activity duration time, and even predict when the user should hydrate himself. Despite these interesting applications, these approaches are limited by a set of pre-trained activities, making them unable to learn new human activities. In this paper, we introduce a novel approach for generating runtime models to give the users feedback that helps them to correctly perform repetitive physical activities. To perform a distributed analysis, the methodology focuses on applying the proposed method to each specific body segment. The method adopts the Restricted Boltzmann Machine to learn the patterns of repetitive physical activities and, at the same time, provides suggestions for adjustments if the repetition is not consistent with the model. The learning and the suggestions are both based on inertial measurement data mainly considering movement acceleration and amplitude. The results show that by applying the model’s suggestions to the evaluation data, the adjusted output was up to 3.68x more similar to the expected movement than the original data.
Detection and Assessment of Changing Drought Events in China in the Context of Climate Change Based on the Intensity–Area–Duration Algorithm
Authors: Ren Yanqun , Liu Jinping , Willems Patrick , Liu Tie , Pham Quoc Bao
Published: September 2023

Drought can have a significant impact on both society and the economy, resulting in issues such as scarcity of water and shortages of food and energy, as well as elevated health risks. However, as global temperatures continue to rise, the impact of drought events is increasingly exacerbated, manifested by an increase in the frequency, intensity, duration, and spatial extent of their effects. Therefore, studying the changing characteristics of drought events with the background of climate change is of great significance. Based on the high-precision and high-resolution CN05.1 dataset, this study obtained the monthly Standardized Precipitation Evapotranspiration Index (SPEI) dataset from 1961 to 2020, and then identified regional drought events in China using the Intensity–Area–Duration (IAD) method, which considers both temporal continuity and spatial dynamics. On this basis, the spatiotemporal variations in frequency, intensity, duration, and affected area of drought events in China and its seven subregions were analyzed. The results showed that the subregions located in the northern region of China generally have lower mean, maximum, and minimum temperatures than those located in the southern region, but the associated interannual change rate of the subregions in the north is higher than that in the south. As for the annual total precipitation, results show a clear pattern of decreasing southeast–northwest gradient, with an increasing trend in the northern subregions and a decreasing trend in the southern subregions except for the subregion south China (SC). The northeast of China (NE), SC, the southwest of China (SW) and north China (NC) are the regions with a high frequency of drought events in China, while the frequency of drought events in NW and Qinghai–Tibetan Plateau (QTP), although lower, is on a significantly increasing trend, and the increasing rate is higher than for the other regions. For drought intensity, Xinjiang (XJ) and QTP had greater drought intensity, and the change rate of these regions with greater drought intensity was also greater. The drought impact area in China showed a significant increasing trend, mainly concentrated in QTP, NW and NE. Particular attention needs to be focused on the southwest of QTP, where drought events in this region show a significant increase in frequency, intensity, duration and impact area.
The Common Agricultural Policy (CAP) in Extremadura (SW Spain) during the Period 2014–2020:New Opportunities for Economic Diversification in Rural Areas?
Authors: Martínez García Francisco Manuel , Nieto Masot Ana , Cárdenas Alonso Gema , Pérez Pintor José Manuel
Published: September 2023

The Common Agricultural Policy (CAP) is a European policy created in the early 1960s to address the food and economic problems affecting European society and the agricultural sector in particular. Throughout its history, the various reforms carried out in this policy have oriented it towards a reduction of direct aid to farmers’ production (due to its excessive cost, among other reasons), in favor of income-related aid. In recent years, the agricultural sector in Extremadura has received CAP aid in a very unequal manner, with a more significant concentration in the agricultural areas where intensive production has been established as a base and where there is a larger population. Thus, the main objective of this research is to analyze the spatial relationships between CAP subsidies and other demographic, economic and social context variables. To achieve the proposed objective, a spatial regression model, namely Geographically Weighted Regression (GWR), has been calculated to determine the relationship between the amounts received from the CAP and the socioeconomic situation of each of the municipalities in the region. The results show a concentration of this aid in the most dynamic areas, with municipalities with a larger population and a more productive agriculture, mainly related to irrigated farms.
Influential Factors in the Evaluation of Agricultural Lands in the Huambo Province, Angola
Authors: Lote Ezequiel , Tavares Fernando Oliveira
Published: September 2023

The possession and appraisal of agricultural fields have significant economic and social impacts. The objective of this study is to examine the perception of farmers in the Huambo Province, Angola, regarding the characteristics that enhance and diminish the value of agricultural lands in the process of buying and selling. The utilized quantitative methodology is based on a questionnaire administered to farmers in the Huambo Province. The sample size consists of 644 respondents. The results allow us to conclude that the income generated from farming activities and the presence of infrastructure greatly facilitate the appraisal of agricultural fields. Conversely, the absence of legal ownership documentation and conflicts related to land ownership reduce the value of the fields. The exploratory factor analysis identified seven determinant factors, responsible for explaining 61.334% of the total variance, in the appraisal of agricultural fields: inherent location characteristics of the property, market dynamics related to agricultural fields, the availability of water on the property, proximity to tourist destinations, physical conditions of the fields, the positive externalities generated, and the advantages offered by the fields. We believe that this study will assist appraisers, farmers, and public administration in understanding the factors that positively and negatively impact the appraisal of agricultural fields.
A Preliminary Exploration of Declarative Intonation in the Chilean Diaspora of Sweden
Authors: Butera Brianna , Rao Rajiv , Parada Maryann
Published: September 2023

Motivated by a growing body of research on heritage Spanish prosody, the current study uses the Sp_ToBi framework for the transcription of Spanish intonation to report trends in phonological targets of broad focus declaratives produced by heritage speakers of Chilean Spanish living in Stockholm, Sweden. Data were collected via semi-structured interviews from six participants belonging to the same social network including two Spanish-dominant first-generation immigrants and four Swedish-dominant second-generation speakers who were born and raised in Sweden and are heritage speakers of Spanish. The G1 participants are the primary source of Spanish input for the G2 speakers. Data were analyzed by identifying word- and phrase-level phonological targets and associating them with the appropriate pitch accent and boundary tones. Results show that the heritage Spanish declarative intonation patterns of the G2 speakers closely resemble those of the G1 speakers. These patterns are scrutinized in terms of the potential influence of Swedish and/or other varieties of Spanish. This analysis exhibits evidence of the importance of source input variety and cross-generational transmission of phonological targets in a heritage language as well as the potential contributions of multiple intonational systems in forming the phonological inventory of heritage speakers.
Recovery after Running an “Everesting” Mountain Ultramarathon
Authors: Ušaj Anton , Lihteneger Vidmajer Jon , Lojen Sonja
Published: September 2023

Blood markers of muscle microdamage and systemic inflammation do not adequately explain the reduced performance observed over a prolonged recovery after running a mountain ultramarathon. This case study aimed to determine whether the reduced performance after the Everesting mountain ultramarathon can be further assessed by considering cardiorespiratory and metabolic alterations determined via repeated incremental and continuous running tests. A single runner (age: 24 years, BM: 70 kg, BMI: 22, Vo2peak: 74 mL∙min−1∙kg−1) was observed over a preparatory period of two months with a one-month recovery period. The Everesting consisted of nine ascents and descents of 9349 vertical metres completed in 18:22 (h:min). During the first phase of the recovery, enhanced peak creatine kinase (800%) and C-reactive protein (44%) levels explained the decreased performance. In contrast, decreased performance during the second, longer phase was associated with a decreased lactate threshold and Vo2 (21% and 17%, respectively), as well as an increased energetic cost of running (15%) and higher endogenous carbohydrate oxidation rates (87%), lactate concentrations (170%) and respiratory muscle fatigue sensations that remained elevated for up to one month. These alterations may represent characteristics that can explain the second phase of the recovery process after Everesting.
Update on Obesity in Psoriasis Patients
Authors: Vata Dan , Tarcau Bogdan Marian , Popescu Ioana Adriana , Halip Ioana Alina , Patrascu Adriana Ionela , Gheuca Solovastru Dragos-Florin , Mocanu Madalina , Chiriac Petronela Cristina , Gheuca Solovastru Laura
Published: September 2023

Psoriasis is a chronic inflammatory skin condition, with genetic, epigenetic, environmental, and lifestyle factors contributing to its onset and recurrence. Severe psoriasis has a great impact on quality of life, which is similar to that of insulin-dependent diabetes, depression, and ischemic heart disease, but with a lower mortality. There is an overlap between the rising incidences of autoimmune diseases and obesity. In recent years, research has shown that there is an association between psoriasis and obesity. Psoriasis is linked to obesity in a two-way manner, as each can precipitate the development of the other. Several adipose tissue-secreted adipokines were shown to be elevated in obese psoriasis patients, exhibiting similar mechanisms of action to those underlying the pathogenesis of psoriasis. Excess body weight can influence not only the treatment response in psoriasis, but also the adverse events, leading to decreased patient compliance. Specific human microbiome patterns have been identified for obesity and psoriasis and could represent a future therapeutic target in selected individuals.
Exploratory Analysis of the Role of Radiomic Features in the Differentiation of Oncocytoma and Chromophobe RCC in the Nephrographic CT Phase
Authors: Aymerich María , García-Baizán Alejandra , Franco Paolo , Otero-García Milagros
Published: September 2023

In diagnostic imaging, distinguishing chromophobe renal cell carcinomas (chRCCs) from renal oncocytomas (ROs) is challenging, since they both present similar radiological characteristics. Radiomics has the potential to help in the differentiation between chRCCs and ROs by extracting quantitative imaging. This is a preliminary study of the role of radiomic features in the differentiation of chRCCs and ROs using machine learning models. In this retrospective work, 38 subjects were involved: 19 diagnosed with chRCCs and 19 with ROs. The CT nephrographic contrast phase was selected in each case. Three-dimensional segmentations of the lesions were performed and the radiomic features were extracted. To assess the reliability of the features, the intraclass correlation coefficient was calculated from the segmentations performed by three radiologists with different degrees of expertise. The selection of features was based on the criteria of excellent intraclass correlation coefficient (ICC), high correlation, and statistical significance. Three machine learning models were elaborated: support vector machine (SVM), random forest (RF), and logistic regression (LR). From 105 extracted features, 41 presented an excellent ICC and 6 were not highly correlated with each other. Only two features showed significant differences according to histological type and machine learning models were developed with them. LR was the better model, in particular, with an 83% precision.
Laparoscopic Pectopexy versus Vaginal Sacrospinous Ligament Fixation in the Treatment of Apical Prolapse
Authors: Brasoveanu Simona , Ilina Razvan , Balulescu Ligia , Pirtea Marilena , Secosan Cristina , Grigoraș Dorin , Chiriac Daniela , Bardan Răzvan , Margan Mădălin-Marius , Alexandru Alexandru , Pirtea Laurențiu
Published: September 2023

Objectives: To compare the follow-up results of a sacrospinous ligament fixation (SSLF) technique for laparoscopic bilateral fixation of the vagina to the iliopectineal ligament via a PVDF-mesh (laparoscopic pectopexy technique, LP) in terms of cure rate and postoperative complications rate. Material and methods: This prospective study included 160 patients diagnosed with pelvic organ prolapse stage II–IV according to the POP-Q system. Eighty-two patients (51.25%) underwent vaginal sacrospinous ligament fixation and seventy-eight patients (48.75%) underwent the laparoscopic pectopexy procedure. Results: The cure rate was high in both groups, 95.12% of the patients (78 out of 82) in the SSLF group and 93.59% of the patients (73 out of 78) in the LP group were cured post surgery, leading to an overall cure rate of 151 out of 160 patients. Pelvic pain was present in 5.00% of all patients, but was notably more frequent in the SSLF group (7, 8.54%) than in the LP group (1, 1.28%). Dyspareunia occurred in 4.37% of all patients, slightly more frequently in the SSLF group (6, 7.32%) than the LP group (1, 1.28%), but without significant difference. Conclusions: The laparoscopic pectopexy procedure has comparably positive follow-up results with the conventional sacrospinous ligament fixation procedure. Both SSLF and LP are effective in the treatment of pelvic organ prolapse, with favorable anatomical and subjective results, a high cure rate and low rates of serious postoperative complications.
Impact of Particulate Matter Exposure and Aerobic Exercise on Circulating Biomarkers of Oxidative Stress, Antioxidant Status, and Inflammation in Young and Aged Mice
Authors: Cho Su-Youn , Roh Hee-Tae
Published: September 2023

Exposure to particulate matter (PM) and exercise training can have antagonistic effects on inflammatory responses and the balance between pro-oxidants and antioxidants in the body. However, the underlying mechanisms of these effects remain unclear. This study aimed to investigate the effects of PM exposure and aerobic exercise training on oxidative stress, antioxidant status, and inflammation in mice of different ages. Two groups of male C57BL/6 mice, comprising forty 1-month-old and forty 12-month-old mice, were exposed to either PM or exercise training or both for 8 weeks. PM exposure led to significantly higher 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α) levels (p < 0.05) and significantly lower superoxide dismutase (SOD) and catalase (CAT) activities (p < 0.05) in both age groups exposed to PM compared to the control groups. Conversely, aerobic exercise training led to significantly lower 8-OHdG, MDA, IL-1β, IL-6, and TNF-α levels (p < 0.05) and significantly higher SOD and CAT activities (p < 0.05) in both age groups receiving exercise training, compared to those exposed to PM. Moreover, young mice in the exercise training and PM group showed significantly lower 8-OHdG, MDA, and IL-1β levels (p < 0.05) and significantly higher SOD and CAT activities (p < 0.05) than young mice in the PM exposure group. However, these levels did not vary significantly between the group of old mice that either received exercise training or exposure to PM. Our results suggest that while PM exposure could cause pro-oxidant/antioxidant imbalances and inflammatory responses, regular aerobic exercise could ameliorate these negative effects, although these vary with age. Nevertheless, the antioxidant and anti-inflammatory effects of exercise were countered by PM exposure, especially in older mice.
Effects of Mycotoxin-Sequestering Agents on Growth Performance and Nutrient Utilization of Growing Pigs Fed Deoxynivalenol-Contaminated Diets
Authors: Kwon Woong Bi , Shin Seung Youp , Song Yoon Soo , Kong Changsu , Kim Beob Gyun
Published: September 2023

The objective of this study was to investigate the effects of supplemental mycotoxin-sequestering agents on growth performance and nutrient utilization in growing pigs fed deoxynivalenol (DON)-contaminated diets. Twelve barrows with an initial body weight of 35.5 kg (standard deviation = 1.3) were assigned to six dietary treatments in a replicated 6 × 5 incomplete Latin square design. Five experimental diets consisted of an uncontaminated diet (PC), a DON-contaminated diet at 6.89 mg/kg (NC), NC + bentonite 0.5%, NC + yeast cell wall 0.5%, and NC + a mixture product 0.5% which consisted of enzymes, microorganisms, minerals, and plant extracts. Pigs had ad libitum access to the five diets. In the last group, the PC diet was restrictedly provided to pigs at the quantity of feed consumption of the NC group. Average daily gain, average daily feed intake, and gain:feed were not affected by supplemental mycotoxin-sequestering agents except for the mixed product that tended to improve (p = 0.064) gain:feed in pigs fed DON-contaminated diets. The apparent total tract digestibility (ATTD) of dry matter was not affected by DON contamination or by supplemental mycotoxin-sequestering agents, whereas the ATTD of Ca was decreased (p = 0.032) by supplemental yeast cell wall in pigs fed DON-contaminated diets. The ATTD of P was greater (p = 0.042) in pigs fed the NC diet compared with the pigs fed the restricted amount of the PC diet. In conclusion, bentonite and yeast cell wall did not affect growth performance of pigs fed DON-contaminated diets, but a supplemental mixed product consisting of enzymes, microorganisms, minerals, and plant extracts partially alleviated the negative effects of dietary DON on the gain:feed of pigs. Calcium digestibility was decreased by supplemental yeast cell wall in pigs fed DON-contaminated diets. Based on the present work, the use of a mixed product consisting of enzymes, microorganisms, minerals, and plant extracts is suggested, and the reduction of Ca digestibility by yeast cell wall needs to be considered in diet formulations.
Interaction of Proteins Involved in Neuronal Proteinopathies
Authors: Kulichikhin Konstantin , Malikova Oksana , Zobnina Anastasia , Zalutskaya Natalia , Rubel Aleksandr
Published: September 2023

Proteinopathy is characterized by the accumulation of aggregates of a specific protein in a target organ, tissue, or cell. The aggregation of the same protein can cause different pathologies as single protein can adopt various amyloidogenic, disease-specific conformations. The conformation governs the interaction of amyloid aggregates with other proteins that are prone to misfolding and, thus, determines disease-specific spectrum of concomitant pathologies. In this regard, a detailed description of amyloid protein conformation as well as spectrum of its interaction with other proteins become a key point for drafting of precise description of the disease. The majority of clinical cases of neuronal proteinopathies is caused by the aggregation of rather limited range of amyloidogenic proteins. Here, we provided the characterization of pathologies, related to the aggregation of amyloid β peptide, tau protein, α-synuclein, TDP-43, and amylin, giving a short description of pathologies themselves, recent advances in elucidation of misfolded protein conformation, with emphasis on those protein aggregates extracted from biological samples, what is known about the interaction of this proteins, and the influence of this interaction on the progression of underlying disease and comorbidities.
The Brain Endothelial Cell Glycocalyx Plays a Crucial Role in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus
Authors: Hayden Melvin R.
Published: September 2023

The brain endothelial cell (BEC) glycocalyx (ecGCx) is a BEC surface coating consisting of a complex interwoven polysaccharide (sweet husk) mesh-like network of membrane-bound proteoglycans, glycoproteins, and glycosaminoglycans (GAGs) covering the apical luminal layer of the brain endothelial cells. The ecGCx may be considered as the first barrier of a tripartite blood–brain barrier (BBB) consisting of (1) ecGCx; (2) BECs; and (3) an extravascular compartment of pericytes, the extracellular matrix, and perivascular astrocytes. Perturbations of this barrier allow for increased permeability in the postcapillary venule that will be permissive to both fluids, solutes, and proinflammatory peripherally derived leukocytes into the perivascular spaces (PVS) which result in enlargement as well as increased neuroinflammation. The ecGCx is known to have multiple functions, which include its physical and charge barrier, mechanical transduction, regulation of vascular permeability, modulation of inflammatory response, and anticoagulation functions. This review discusses each of the listed functions in detail and utilizes multiple transmission electron micrographs and illustrations to allow for a better understanding of the ecGCx structural and functional roles as it relates to enlarged perivascular spaces (EPVS). This is the fifth review of a quintet series that discuss the importance of EPVS from the perspective of the cells of brain barriers. Attenuation and/or loss of the ecGCx results in brain barrier disruption with increased permeability to proinflammatory leukocytes, fluids, and solutes, which accumulate in the postcapillary venule perivascular spaces. This accumulation results in obstruction and results in EPVS with impaired waste removal of the recently recognized glymphatic system. Importantly, EPVS are increasingly being regarded as a marker of cerebrovascular and neurodegenerative pathology.
Carbon Emissions Effect on Vendor-Managed Inventory System Considering Displaced Re-Start-Up Production Time
Authors: Alamri Adel A.
Published: September 2023

Background: The classical mathematical formulation of the vendor-managed inventory (VMI) model assumes an infinite planning horizon, and consequently, the solution derived ignored the impact of the first cycle. The classical formulation is associated with another implicit assumption that input parameters remain static indefinitely. Methods: This paper develops two mathematical models for VMI for a joint economic lot-sizing (JELS) policy. Each model considers investment in green production, energy used for keeping items in storage, and carbon emissions from production, storage, and transportation activities under the carbon cap-and-trade policy. The first model underlies the first cycle, while the second underlies subsequent cycles. Results: The re-start-up production time for subsequent cycles commences only at the time required to produce and replenish the first lot, which implies further cost reduction. Mathematical formulations are perceived as important both for academics and practitioners. For example, the base model of the first cycle (subsequent cycles) generates an optimal produced quantity with 18.42% (4.35%) less total system cost when compared with the pest scenario in favor of the existing literature. Moreover, such a percentage of total system cost reduction increases as the production rate increases. Further, the proposed models not only produce better results but also offer the opportunity to adjust the input parameters for subsequent cycles, where each cycle is independent from the previous one. Conclusions: The emissions generated by the system are very much related to the demand rate and the amount of investment in green production. Illustrative examples, special cases, model overview, and managerial insights are given. The discussion related to the contribution of the proposed model, the concluding remarks, and further research are also provided. The proposed model rectifies the base model adopted by the existing literature, which can be further extended to be implemented in several interesting further inquiries related to JELS inventory mathematical modeling.
Numerical Investigation of Bump Foil Configurations Effect on Gas Foil Thrust Bearing Performance Based on a Thermos-Elastic-Hydrodynamic Model
Authors: Hu Bin , Hou Anping , Deng Rui , Wang Rui , Wu Zhiyong , Ni Qifeng , Li Zhong
Published: September 2023

The performance of gas foil thrust bearings is critical to the successful design and operation of the high axial load rotatory machines that employ gas foil bearings. However, our understanding of gas foil thrust bearings remains incomplete. To enhance our understanding and predict the performance of gas foil thrust bearings, we have established a detailed three-dimensional thermo-elastic-hydrodynamic model of a gas foil thrust bearing based on a fluid-thermal-structure interaction approach in this study. To validate the accuracy of our model, a gas foil thrust bearing test rig was developed. Moreover, we present a numerical investigation of the influence of bump foil configurations on gas foil thrust bearing performance. The results show that the gas foil thrust bearing that fixes the bump foil at the trailing edge and splits the bump foil into several strips exhibits a 36.4% increase in load capacity compared to the gas foil thrust bearing that fixes a whole piece of bump foil at the leading edge. Fixing the bump foil at the trailing edge and splitting it into several strips effectively decreases power loss and reduces the risk of bearing thermal failure.
Predicting Low-Modulus Biocompatible Titanium Alloys Using Machine Learning
Authors: Marković Gordana , Manojlović Vaso , Ružić Jovana , Sokić Miroslav
Published: September 2023

Titanium alloys have been present for decades as the main components for the production of various orthopedic and dental elements. However, modern times require titanium alloys with a low Young’s modulus, and without the presence of cytotoxic alloying elements. Machine learning was used with aim to analyze biocompatible titanium alloys and predict the composition of Ti alloys with a low Young’s modulus. A database was created using experimental data for alloy composition, Young’s modulus, and mechanical and thermal properties of biocompatible titanium alloys. The Extra Tree Regression model was built to predict the Young’s modulus of titanium alloys. By processing data of 246 alloys, the specific heat was discovered to be the most influential parameter that contributes to the lowering of the Young’s modulus of titanium alloys. Further, the Monte Carlo method was used to predict the composition of future alloys with the desired properties. Simulation results of ten million samples, with predefined conditions for obtaining titanium alloys with a Young’s modulus lower than 70 GPa, show that it is possible to obtain several multicomponent alloys, consisting of five main elements: titanium, zirconium, tin, manganese and niobium.
The Influences of Ultrasonic Vibrations on Laser Cladding Ni60/WC-TiO2+La2O3 Composite Coating
Authors: Huang Xu , Chen Yanchun , Jiang Jibin , Lian Guofu , Chen Changrong
Published: September 2023

The optimal process parameters of ultrasonic-assisted processing were studied to further improve the molding quality and mechanical properties of Ni60/WC-TiO2+La2O3 composite coating. A single-factor experiment was used to explore the influences of ultrasonic vibration frequencies on Ni60/WC-TiO2+La2O3 composite coating. The microstructure, elemental composition, phase composition, hardness, and wear resistance of the coating were studied using scanning electron microscopy (SEM), an X-ray diffractometer (XRD), an energy spectrometer, a microhardness meter, a friction and wear tester, and other equipment. Ultrasonic vibrations significantly improved the problems of pores in the coating, and the porosity was reduced from 0.13 to 0.014%. When the vibration frequency was 32 kHz in the experiment, the aspect ratio of the coating was optimized from 2.06 to 2.48, the dilution rate increased from 5.60 to 5.79%, the hardness increased from 960.25 to 988.45 HZ1.0, and the friction coefficient was reduced from 0.34 to 0.27. The coating performance was significantly improved, and the research results provide a reference for preparing excellent Ni60/WC-TiC+La2O3 composite coating.
Supported Gold Catalysts for Base-Free Furfural Oxidation: The State of the Art and Machine-Learning-Enabled Optimization
Authors: Thuriot-Roukos Joëlle , Ferraz Camila Palombo , K. Al Rawas Hisham , Heyte Svetlana , Paul Sébastien , Itabaiana Jr Ivaldo , Pietrowski Mariusz , Zieliński Michal , Ghazzal Mohammed N. , Dumeignil Franck , Wojcieszak Robert
Published: September 2023

Supported gold nanoparticles have proven to be highly effective catalysts for the base-free oxidation of furfural, a compound derived from biomass. Their small size enables a high surface-area-to-volume ratio, providing abundant active sites for the reaction to take place. These gold nanoparticles serve as catalysts by providing surfaces for furfural molecules to adsorb onto and facilitating electron transfer between the substrate and the oxidizing agent. The role of the support in this reaction has been widely studied, and gold–support interactions have been found to be beneficial. However, the exact mechanism of furfural oxidation under base-free conditions remains an active area of research and is not yet fully understood. In this review, we delve into the essential factors that influence the selectivity of furfural oxidation. We present an optimization process that highlights the significant role of machine learning in identifying the best catalyst for this reaction. The principal objective of this study is to provide a comprehensive review of research conducted over the past five years concerning the catalytic oxidation of furfural under base-free conditions. By conducting tree decision making on experimental data from recent articles, a total of 93 gold-based catalysts are compared. The relative variable importance chart analysis reveals that the support preparation method and the pH of the solution are the most crucial factors determining the yield of furoic acid in this oxidation process.
Interface Structure, Dielectric Behavior and Temperature Stability of Ba(Mg1/3Ta2/3)O3/PbZr0.52Ti0.48O3 Thin Films
Authors: Wu Zhi , Liu Yifei , Zhou Jing , Zhao Hong , Qin Zhihui
Published: September 2023

Multilayer films can achieve advanced properties and a wide range of applications. The heterogeneous interface plays an important role in the performances of multilayer films. In this paper, the effects of the interface of Ba(Mg1/3Ta2/3)O3/PbZr0.52Ti0.48O3 (BMT/PZT) thin films on dielectric behavior and temperature stability are investigated. The heterogeneous interface structures are characterized by Auger electron spectroscopy (AES). The PZT-BMT interface is different from the BMT-PZT interface in thickness. For the PZT-BMT interface, the PZT thin films are diffused to the whole BMT layers, and the interface thickness is about 90 nm, while the BMT-PZT interface’s thickness is only about 8.6 nm. The presence of heterogeneous interfaces can improve the performances of BMT/PZT thin films and expand their applications. The dielectric constant of BBPP thin films is significantly lower than BPBP thin films, while the dielectric loss is exactly the opposite. The more interfaces there are, the greater the dielectric constant. The relationship between the electric-field-dependent dielectric constant curve and the P-E curve is established. The equivalent interface barrier of the diode is used to show that the dielectric peaks under the positive and negative voltage are different. Similarly, heterogeneous interfaces show a certain improvement in dielectric tunability and temperature stability.
Crack Resistance of Prestressed Reinforced Concrete Beams with Wire Rope Reinforcement
Authors: Yusufkhojaev Saidgani , Yusupov Rakhimbay , Alimov Xikmat , Makhmudov Jaloliddin , Choi Eunsoo
Published: September 2023

One of the main objectives of capital construction worldwide is to increase the efficiency of construction. To achieve this, a significant improvement in the quality of concrete and reinforced concrete is required. Nowadays, in developed countries, one of the key directions for enhancing the efficiency of concrete and reinforced concrete is reducing their density by using inexpensive and high-quality local porous fillers. In recent years, the use of concrete structures with porous fillers based on ceramporite in load-bearing reinforced concrete structures has allowed for the improvement of their technical and economic indicators and the reduction in their own weight by up to 35%. This, in turn, is considered an essential factor in seismic zones, and therefore, special attention is paid to these issues. This article presents the data of experimental and theoretical studies obtained from investigating the crack resistance of prestressed lightweight reinforced concrete flexural elements with wire rope reinforcement. The main factors influencing crack resistance were considered, including the effects of two types of porous filler (ceramporite), two types of concrete, concrete strength, percentage of reinforcement, and level of precompression. The tests were conducted using short-term and repeated loadings. Based on the analysis of the obtained data, some refinements have been made to the methodology for calculating the crack resistance of such structures according to current design standards.
Evaluation of the Superiority of Lightweight-Aggregate-Concrete Prestressed Box Girders in Terms of Durability and Prestress Loss
Authors: Chen How-Ji , Kuo Cheng-Chang , Tang Chao-Wei
Published: September 2023

This case study aimed to compare the differences in the durability and prestress loss between normal-weight-concrete (NC) and lightweight-aggregate-concrete (LWC) prestressed box girders, which were constructed at the same time in the same area, so as to verify the superiority of using synthetic lightweight aggregate (LWA) made from reservoir sediments in prestressed bridges. For the NCs and LWCs used in the prestressed box girders, the basic mechanical properties (compressive strength, flexural strength, splitting tensile strength, and elastic modulus) were tested, as well as the durability properties (chloride ion penetration resistance and rapid chloride permeability). Then, through the prestress-monitoring system, the prestress losses of the two groups of prestressed box girders were tracked. The results of the durability test confirmed that LWC can inhibit the penetration of air, water, and chloride ions by strengthening the interfacial transition zone between the aggregate and the cement paste, thereby improving its durability. Moreover, the magnetic-flux prestress loss of the NC prestressed box girder reached 8.1%. In contrast, the magnetic-flux prestress losses on both sides of the LWC prestressed box girder were 4.6% and 4.9%, respectively. This verified that, under the same environmental conditions, the use of LWC produced less of a prestress loss than the use of NC.
Comparison of Repair Methods for Cracked Titanium Alloy Aircraft Structures with Single-Sided Adhesively Bonded Composite Patches
Authors: Hu Junshan , Li Chengyu , Fang Jinrong , Chen Shizhan , Xuan Shanyong , Tian Wei
Published: September 2023

Composite patches are widely accepted as a useful practice for the repair of cracked aircraft components and the repair method is of vital importance to the final performance of the repaired structures. The present research experimentally studied the repair efficiency and processing stability of pre-cured, prepreg (including unidirectional and plain weave prepregs) and wet-layup methods for use on cracked Ti-alloy panels through the configuration of a butt joint bonded with a one-sided composite patch. The efficiency and stability of these repair methods were elaborately evaluated and compared via the load bearing behavior, the microstructure of the bonding interface, and the structural failure morphology through two batches of testing specimens. Typical patterns were found in load-displacement curves where the initial damage and ultimate bearing load points divided them into elastic-linear, damage propagation and complete fracture phases. Although the co-cure process of both unidirectional prepreg and wet-layup methods can form a jigsaw-like demarcation interface between the adhesive layer and the composite patch to achieve a good bonding force and a high recovery of loading performance, the latter presents porous patches with a high coefficient of variation in load-carrying capacity. Conversely, the pre-cured laminate and the plain weave prepreg patches failed to restore the mechanical properties owing to the weak bonding interface and the low axial patch strength, respectively. The unidirectional prepreg patch was proven to be the optimal repair method for the cracked metallic structures when balancing repair efficiency and processing stability.
Multifunctional Motion Sensing Enabled by Laser-Induced Graphene
Authors: Deng Bowen , Wang Zongyuan , Liu Weiguang , Hu Bin
Published: September 2023

The development of flexible sensors based on laser-induced graphene (LIG) has recently attracted much attention. It was commonly generated by laser-ablating commercial polyimide (PI). However, the weak mechanical extensibility of PI limits the development and diversified applications of LIG-based sensors. In this work, we adopted medical polyurethane (PU) tapes to peel off the LIG generated on PI and developed flexible and wearable sensors based on the proposed LIG/PU composite structure. Compared with other methods for LIG transfer, PU tape has many advantages, including a simplified process and being less time-consuming. We characterized the LIG samples generated under different laser powers and analyzed the property differences introduced by the transfer operation. We then studied the impact of fabrication mode on the strain sensitivity of the LIG/PU and optimized the design of a LIG/PU-based strain sensor, which possessed a gauge factor (GF) of up to 263.6 in the strain range of 75–90%. In addition, we designed a capacitive pressure sensor for tactile sensing, which is composed of two LIG/PU composite structures and a PI space layer. These LIG flexible devices can be used for human motion monitoring and tactile perception in sports events. This work provides a simple, fast, and low-cost way for the preparation of multifunctional sensor systems with good performance, which has a broad application prospect in human motion monitoring.