bluuebunny/crossref_metadata_2025 huggingface dataset:
Intsia bijuga Heartwood Extract and Its Phytosome as Tyrosinase Inhibitor, Antioxidant, and Sun Protector
Authors: Sari Rita Kartika , Prayogo Yanico Hadi , Sari Ratih Afrida Lismana , Asidah Nur , Rafi Mohamad , Wientarsih Ietje , Darmawan Wayan
Published: December 2021

Intsia bijuga (Colebr.) wood (Indonesian: Merbau) is commercial wood with high economic value and is most commonly found in Indonesia. Intsia wood extractives have biological activities related to their potential as natural active ingredients for antiaging cosmetics This study aimed to select the best extraction solvent and phytosome formulation of I. bijuga heartwood extract as an active ingredient for topical antiaging cosmetics. There were five and three variations on extraction solvent and phytosome formulation, respectively. Three main antiaging activity parameters, namely antioxidant, antityrosinase, and sun protection factor (SPF) values, were considered in selecting the best extract and phytosome formula. The results showed that 50% ethanol possessed good antioxidant and antityrosinase activity, but was lower in SPF value, which was significantly different than in other extracts. The phytochemical profile revealed robidanol and robinetin as the main constituent in five I. bijuga extracts. Phytosome F3 possessed high antioxidant, antityrosinase, and SPF values compared to other 50% ethanol phytosome extracts. It could be concluded that I. bijuga ethanol extracts and its phytosome are potent enough to be developed as an antiaging active ingredient in topical use cosmetics.
The Contribution of Non-Wood Forest Products to Rural Livelihoods in Tunisia: The Case of Aleppo Pine
Authors: Taghouti Ibtissem , Ouertani Emna , Guesmi Bouali
Published: December 2021

Research Highlights: Recently, there has been a growing interest in the contribution of Non-Wood Forest Products (NWFPs) to livelihoods and food security among local populations in Tunisia. NWFPs have gained special attention given the relevance of this forest heritage to alleviate poverty and improve household economies. Background and Objectives: This study focuses on determining the contribution of Aleppo pine production to local household livelihood and food security in Tunisia (Siliana province). The relevance of this region as a leading Tunisian Aleppo pine producer makes the analysis especially interesting. Materials and Methods: Data were obtained using structured surveys distributed among rural household heads during the collection season. A logistic regression as well as food security indicators were calculated to evaluate the contribution of NWFPs to household livelihood. Results: Empirical findings support evidence that there is a significant difference between the alternative sources of revenues. The collection of Aleppo pine was significantly affected by gender, attending extension days and agricultural training program, distance to market, household size and livestock activity. Conclusions: Aleppo pine plays an important role in supporting rural livelihoods and provides an important safety net for the local population throughout the year.
Effects of Urbanization on the Dynamics and Equity of Access to Urban Parks from 2000 to 2015 in Beijing, China
Authors: Kong Xiangqi , Sun Yan , Xu Chengyang
Published: December 2021

Urban parks provide multiple ecosystem services as an important element of the urban space and improve human health and wellbeing. This study used the Gaussian-based 2SFCA method to evaluate the spatiotemporal distribution of and changes in park accessibility within the Sixth Ring Road in Beijing over 15 years. The study also used bivariate correlation analysis to analyze the relationship between urbanization factors and park access. The results showed that the overall park accessibility in both quantity and proximity had increased from 2000 to 2015, but there were still certain areas (percentage) that had limited access to parks. The inequity of distribution in park accessibility had been detected accompanying the rapid increase in park quantity in 2015. Furthermore, the development of urban parks mismatched that of urbanization in terms of urban land increase. The correlation between accessibility changes and population urbanization is not significant. Proper urban green space planning based on the distribution of population density and urban land use is indispensable in avoiding the aggravation of inequity in the process of urban expansion. This study contributes to the assessment of the current park allocation efficiency and helps urban planners and policymakers make prompt adjustments in the rapidly urbanizing process.
How Can Remote Sensing Reduce Required Human Intervention in Robotic Forest Regeneration
Authors: Orumaa Argo , Vellak Priit , Lang Mait , Metslaid Marek , Kägo Riho , Noorma Mart
Published: December 2021

In this article, we introduce an alternative solution for forest regeneration based on unmanned ground vehicles (UGV) and describe requirements for external data, which could significantly increase the level of automation. Over the past few decades, the global forested area has decreased, and there is a great need to restore and regenerate forests. Challenges such as the lack of labor and high costs demand innovative approaches for forest regeneration. Mechanization has shown satisfactory results in terms of time-efficient planting, although its usage is limited by high operational costs. Innovative technologies must be cost-efficient and profitable for large scale usage. Automation could make mechanized forest regeneration feasible. Forest regeneration operations can be automated using a purpose built unmanned platform. We developed a concept to automate forest planting operations based on mobility platform. The system requires external data for efficient mobility in clear-cut areas. We developed requirements for external data, analyzed available solutions, and experimented with the most promising option, the SfM (structure from motion) technique. Earth observation data are useful in the planning phase. A DEM (digital terrain model) for UGV planter operations can be constructed using ALS (airborne laser scanning), although it may be restricted by the cost. Low-altitude flights by drones equipped with digital cameras or lightweight laser scanners provided a usable model of the terrain. This model was precise (3–20 cm) enough for manually planning of the trajectory for the planting operation. This technique fulfilled the system requirements, although it requires further development and will have to be automated for operational use.
The Machine-to-Everything (M2X) Economy: Business Enactments, Collaborations, and e-Governance
Authors: Leiding Benjamin , Sharma Priyanka , Norta Alexander
Published: December 2021

Nowadays, business enactments almost exclusively focus on human-to-human business transactions. However, the ubiquitousness of smart devices enables business enactments among autonomously acting machines, thereby providing the foundation for the machine-driven Machine-to-Everything (M2X) Economy. Human-to-human business is governed by enforceable contracts either in the form of oral, or written agreements. Still, a machine-driven ecosystem requires a digital equivalent that is accessible to all stakeholders. Additionally, an electronic contract platform enables fact-tracking, non-repudiation, auditability and tamper-resistant storage of information in a distributed multi-stakeholder setting. A suitable approach for M2X enactments are electronic smart contracts that allow to govern business transactions using a computerized transaction protocol such as a blockchain. In this position paper, we argue in favor of an open, decentralized and distributed smart contract-based M2X Economy that supports the corresponding multi-stakeholder ecosystem and facilitates M2X value exchange, collaborations, and business enactments. Finally, it allows for a distributed e-governance model that fosters open platforms and interoperability. Thus, serving as a foundation for the ubiquitous M2X Economy and its ecosystem.
Relationship between Structure and Biological Activity of Various Vitamin K Forms
Authors: Bus Katarzyna , Szterk Arkadiusz
Published: December 2021

Vitamin K is involved many biological processes, such as the regulation of blood coagulation, prevention of vascular calcification, bone metabolism and modulation of cell proliferation. Menaquinones (MK) and phylloquinone vary in biological activity, showing different bioavailability, half-life and transport mechanisms. Vitamin K1 and MK-4 remain present in the plasma for 8–24 h, whereas long-chain menaquinones can be detected up to 96 h after administration. Geometric structure is also an important factor that conditions their properties. Cis-phylloquinone shows nearly no biological activity. An equivalent study for menaquinone is not available. The effective dose to decrease uncarboxylated osteocalcin was six times lower for MK-7 than for MK-4. Similarly, MK-7 affected blood coagulation system at dose three to four times lower than vitamin K1. Both vitamin K1 and MK-7 inhibited the decline in bone mineral density, however benefits for the occurrence of cardiovascular diseases have been observed only for long-chain menaquinones. There are currently no guidelines for the recommended doses and forms of vitamin K in the prevention of osteoporosis, atherosclerosis and other cardiovascular disorders. Due to the presence of isomers with unknown biological properties in some dietary supplements, quality and safety of that products may be questioned.
A Study on Controllability of a Class of Impulsive Fractional Nonlinear Evolution Equations with Delay in Banach Spaces
Authors: Zhao Daliang
Published: December 2021

Under a new generalized definition of exact controllability we introduced and with a appropriately constructed time delay term in a special complete space to overcome the delay-induced-difficulty, we establish the sufficient conditions of the exact controllability for a class of impulsive fractional nonlinear evolution equations with delay by using the resolvent operator theory and the theory of nonlinear functional analysis. Nonlinearity in the system is only supposed to be continuous rather than Lipschitz continuous by contrast. The results obtained in the present work are generalizations and continuations of the recent results on this issue. Further, an example is presented to show the effectiveness of the new results.
Capacity and the Corresponding Heat Semigroup Characterization from Dunkl-Bounded Variation
Authors: Meng Xiangling , Liu Yu , Xie Xiangyun
Published: December 2021

In this paper, we study some important basic properties of Dunkl-bounded variation functions. In particular, we derive a way of approximating Dunkl-bounded variation functions by smooth functions and establish a version of the Gauss–Green Theorem. We also establish the Dunkl BV capacity and investigate some measure theoretic properties, moreover, we show that the Dunkl BV capacity and the Hausdorff measure of codimension one have the same null sets. Finally, we develop the characterization of a heat semigroup of the Dunkl-bounded variation space, thereby giving its relation to the functions of Dunkl-bounded variation.
The Craft of Fractional Modelling in Science and Engineering: II and III
Authors: Hristov Jordan
Published: December 2021

A comprehensive understanding of fractional systems plays a pivotal role in practical applications [...]
Bioactive Inks Development for Osteochondral Tissue Engineering: A Mini-Review
Authors: Bakhtiary Negar , Liu Chaozong , Ghorbani Farnaz
Published: December 2021

Nowadays, a prevalent joint disease affecting both cartilage and subchondral bone is osteoarthritis. Osteochondral tissue, a complex tissue unit, exhibited limited self-renewal potential. Furthermore, its gradient properties, including mechanical property, bio-compositions, and cellular behaviors, present a challenge in repairing and regenerating damaged osteochondral tissues. Here, tissue engineering and translational medicine development using bioprinting technology provided a promising strategy for osteochondral tissue repair. In this regard, personalized stratified scaffolds, which play an influential role in osteochondral regeneration, can provide potential treatment options in early-stage osteoarthritis to delay or avoid the use of joint replacements. Accordingly, bioactive scaffolds with possible integration with surrounding tissue and controlling inflammatory responses have promising future tissue engineering perspectives. This minireview focuses on introducing biologically active inks for bioprinting the hierarchical scaffolds, containing growth factors and bioactive materials for 3D printing of regenerative osteochondral substitutes.
Genetics and Epigenetics in Allergic Rhinitis
Authors: Choi Bo Yoon , Han Munsoo , Kwak Ji Won , Kim Tae Hoon
Published: December 2021

The pathogenesis of allergic rhinitis is associated with genetic, environmental, and epigenetic factors. Genotyping of single nucleotide polymorphisms (SNPs) is an advanced technique in the field of molecular genetics that is closely correlated with genome-wide association studies (GWASs) in large population groups with allergic diseases. Many recent studies have paid attention to the role of epigenetics, including alteration of DNA methylation, histone acetylation, and miRNA levels in the pathogenesis of allergic rhinitis. In this review article, genetics and epigenetics of allergic rhinitis, including information regarding functions and significance of previously known and newly-discovered genes, are summarized. Directions for future genetic and epigenetic studies of allergic rhinitis are also proposed.
Small Molecule Drugs Targeting Non-Coding RNAs as Treatments for Alzheimer’s Disease and Related Dementias
Authors: Nguyen Lien D. , Chau Rachel K. , Krichevsky Anna M.
Published: December 2021

Despite the enormous burden of Alzheimer’s disease and related dementias (ADRD) on patients, caregivers, and society, only a few treatments with limited efficacy are currently available. While drug development conventionally focuses on disease-associated proteins, RNA has recently been shown to be druggable for therapeutic purposes as well. Approximately 70% of the human genome is transcribed into non-protein-coding RNAs (ncRNAs) such as microRNAs, long ncRNAs, and circular RNAs, which can adopt diverse structures and cellular functions. Many ncRNAs are specifically enriched in the central nervous system, and their dysregulation is implicated in ADRD pathogenesis, making them attractive therapeutic targets. In this review, we first detail why targeting ncRNAs with small molecules is a promising therapeutic strategy for ADRD. We then outline the process from discovery to validation of small molecules targeting ncRNAs in preclinical studies, with special emphasis on primary high-throughput screens for identifying lead compounds. Screening strategies for specific ncRNAs will also be included as examples. Key challenges—including selecting appropriate ncRNA targets, lack of specificity of small molecules, and general low success rate of neurological drugs and how they may be overcome—will be discussed throughout the review.
Genetic Diversity and Population Structure Analysis of the USDA Olive Germplasm Using Genotyping-By-Sequencing (GBS)
Authors: Islam A. S. M. Faridul , Sanders Dean , Mishra Amit Kumar , Joshi Vijay
Published: December 2021

Olives are one of the most important fruit and woody oil trees cultivated in many parts of the world. Olive oil is a critical component of the Mediterranean diet due to its importance in heart health. Olives are believed to have been brought to the United States from the Mediterranean countries in the 18th century. Despite the increase in demand and production areas, only a few selected olive varieties are grown in most traditional or new growing regions in the US. By understanding the genetic background, new sources of genetic diversity can be incorporated into the olive breeding programs to develop regionally adapted varieties for the US market. This study aimed to explore the genetic diversity and population structure of 90 olive accessions from the USDA repository along with six popular varieties using genotyping-by-sequencing (GBS)-generated SNP markers. After quality filtering, 54,075 SNP markers were retained for the genetic diversity analysis. The average gene diversity (GD) and polymorphic information content (PIC) values of the SNPs were 0.244 and 0.206, respectively, indicating a moderate genetic diversity for the US olive germplasm evaluated in this study. The structure analysis showed that the USDA collection was distributed across seven subpopulations; 63% of the accessions were grouped into an identifiable subpopulation. The phylogenetic and principal coordinate analysis (PCoA) showed that the subpopulations did not align with the geographical origins or climatic zones. An analysis of the molecular variance revealed that the major genetic variation sources were within populations. These findings provide critical information for future olive breeding programs to select genetically distant parents and facilitate future gene identification using genome-wide association studies (GWAS) or a marker-assisted selection (MAS) to develop varieties suited to production in the US.
Genomics Reveal Admixture and Unexpected Patterns of Diversity in a Parapatric Pair of Butterflies
Authors: Tahami Mohadeseh Sadat , Dincă Vlad , Lee Kyung Min , Vila Roger , Joshi Mukta , Heikkilä Maria , Dapporto Leonardo , Schmid Sarah , Huemer Peter , Mutanen Marko
Published: December 2021

We studied the evolutionary relationship of two widely distributed parapatric butterfly species, Melitaea athalia and Melitaea celadussa, using the ddRAD sequencing approach, as well as genital morphology and mtDNA data. M. athalia was retrieved as paraphyletic with respect to M. celadussa. Several cases of mito-nuclear discordance and morpho-genetic mismatch were found in the contact zone. A strongly diverged and marginally sympatric clade of M. athalia from the Balkans was revealed. An in-depth analysis of genomic structure detected high levels of admixture between M. athalia and M. celadussa at the contact zone, though not reaching the Balkan clade. The demographic modelling of populations supported the intermediate genetic make-up of European M. athalia populations with regards to M. celadussa and the Balkan clade. However, the dissimilarity matrix of genotype data (PCoA) suggested the Balkan lineage having a genetic component that is unrelated to the athalia-celadussa group. Although narrowly sympatric, almost no signs of gene flow were found between the main M. athalia group and the Balkan clade. We propose two possible scenarios on the historical evolution of our model taxa and the role of the last glacial maximum in shaping their current distribution. Finally, we discuss the complexities regarding the taxonomic delimitation of parapatric taxa.
SUMO-Based Regulation of Nuclear Positioning to Spatially Regulate Homologous Recombination Activities at Replication Stress Sites
Authors: Schirmeisen Kamila , Lambert Sarah A. E. , Kramarz Karol
Published: December 2021

DNA lesions have properties that allow them to escape their nuclear compartment to achieve DNA repair in another one. Recent studies uncovered that the replication fork, when its progression is impaired, exhibits increased mobility when changing nuclear positioning and anchors to nuclear pore complexes, where specific types of homologous recombination pathways take place. In yeast models, increasing evidence points out that nuclear positioning is regulated by small ubiquitin-like modifier (SUMO) metabolism, which is pivotal to maintaining genome integrity at sites of replication stress. Here, we review how SUMO-based pathways are instrumental to spatially segregate the subsequent steps of homologous recombination during replication fork restart. In particular, we discussed how routing towards nuclear pore complex anchorage allows distinct homologous recombination pathways to take place at halted replication forks.
MiRNA-Regulated Pathways for Hypertrophic Cardiomyopathy: Network-Based Approach to Insight into Pathogenesis
Authors: Osmak German , Baulina Natalia , Kiselev Ivan , Favorova Olga
Published: December 2021

Hypertrophic cardiomyopathy (HCM) is the most common hereditary heart disease. The wide spread of high-throughput sequencing casts doubt on its monogenic nature, suggesting the presence of mechanisms of HCM development independent from mutations in sarcomeric genes. From this point of view, HCM may arise from the interactions of several HCM-associated genes, and from disturbance of regulation of their expression. We developed a bioinformatic workflow to study the involvement of signaling pathways in HCM development through analyzing data on human heart-specific gene expression, miRNA-target gene interactions, and protein–protein interactions, available in open databases. Genes regulated by a pool of miRNAs contributing to human cardiac hypertrophy, namely hsa-miR-1-3p, hsa-miR-19b-3p, hsa-miR-21-5p, hsa-miR-29a-3p, hsa-miR-93-5p, hsa-miR-133a-3p, hsa-miR-155-5p, hsa-miR-199a-3p, hsa-miR-221-3p, hsa-miR-222-3p, hsa-miR-451a, and hsa-miR-497-5p, were considered. As a result, we pinpointed a module of TGFβ-mediated SMAD signaling pathways, enriched by targets of the selected miRNAs, that may contribute to the cardiac remodeling in HCM. We suggest that the developed network-based approach could be useful in providing a more accurate glimpse on pathological processes in the disease pathogenesis.
Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS
Authors: Janaththani Panchadsaram , Srinivasan Sri Lakshmi , Batra Jyotsna
Published: December 2021

Long non-coding RNAs (lncRNAs) are emerging as key players in a variety of cellular processes. Deregulation of the lncRNAs has been implicated in prostate and breast cancers. Recently, germline genetic variations associated with cancer risk have been correlated with lncRNA expression and/or function. In addition, single nucleotide polymorphisms (SNPs) at well-characterized cancer-associated lncRNAs have been analyzed for their association with cancer risk. These SNPs may occur within the lncRNA transcripts or spanning regions that may alter the structure, function, and expression of these lncRNA molecules and contribute to cancer progression and may have potential as therapeutic targets for cancer treatment. Additionally, some of these lncRNA have a tissue-specific expression profile, suggesting them as biomarkers for specific cancers. In this review, we highlight some of the cancer risk-associated SNPs that modulated lncRNAs with a potential role in prostate and breast cancers and speculate on how these lncRNAs may contribute to cancer development.
India Indenting Eurasia: A Brief Review and New Data from the Yongping Basin on the SE Tibetan Plateau
Authors: Yang Tiannan , Yan Zhen , Xue Chuandong , Xin Di , Dong Mengmeng
Published: December 2021

Successive indentations of Eurasia by India have led to the Tibet-Himalaya E–W orthogonal collision belt and the SE Tibetan Plateau N–S oblique collision belt along the frontal and eastern edges of the indenter, respectively. The belts exhibit distinctive lithospheric structures and tectonic evolutions. A comprehensive compilation of available geological and geophysical data reveals two sudden tectonic transitions in the early Eocene and the earliest Miocene, respectively, of the tectonic evolution of the orthogonal belt. Synthesizing geological and geochronological data helps us to suggest a NEE–SWW trending, ~450 km-long, ~250 km-wide magmatic zone in SE Tibet, which separates the oblique collision belt (eastern and SE Tibet) into three segments of distinctive seismic structures including the mantle and crust anisotropies. The newly identified Yongping basin is located in the central part of the magmatic zone. Geochronological and thermochronological data demonstrate that (1) this basin and the magmatic zone started to form at ~48 Ma likely due to NNW–SSE lithosphere stretching according to the spatial coincidence of the concentrated mantle-sourced igneous rocks on the surface with the seismic anomalies at depth; and (2) its fills was shortened in the E–W direction since ~23 Ma. These two dates correspond to the onset of the first and second tectonic transitions of the orthogonal collision belt. As such, both the orthogonal and oblique belts share a single time framework of their tectonic evolution. By synthesizing geological and geophysical data of both collision belts, the indenting process can be divided into three stages separated by two tectonic transitions. Continent–continent collision as a piston took place exclusively during the second stage. During the other two stages, the India lithosphere underthrust beneath Eurasia.
The European Health Union: European Union’s Concern about Health for All. Concepts, Definition, and Scenarios
Authors: Nabbe Marie , Brand Helmut
Published: December 2021

The COVID-19 pandemic brought visibility and intensified the discussions on the European Union’s (EU) health mandate. The proposals of the European Commission (EC) to move towards a European Health Union (EHU) can be seen as a starting point towards more integration in health. However, the definition of what the EHU will look like is not clear. This paper searches to find a common definition, and/or features for this EHU through a systematic literature review performed in May 2021. “European Union’s concern about health for all” is suggested as a definition. The main drivers identified to develop an EHU are: surveillance and monitoring, crisis preparedness, funding, political will, vision of public health expenditures, population’s awareness and interest, and global health. Based on these findings, five scenarios were developed: making a full move towards supranational action; improving efficiency in the actual framework; more coordination but no real change; in a full intergovernmentalism direction; and fragmentation of the EU. The scenarios show that the development of a EHU is possible inside the current legal framework. However, it will rely on increased coordination and has a focus on cross-border health threats. Any development will be strongly linked to political choices from Member States.
Self-Participation Experiences among Well-Adapted Hemodialysis Patients
Authors: Szu Li-Yun , Tsao Lee-Ing , Chen Shu-Chuan , Ho May-Lien
Published: December 2021

A successful self-participation experience empowers patients to adapt to living with hemodialysis. However, few studies regarding the subjective experiences of such patient participation have been conducted. This study’s purpose was to describe hemodialysis patients’ perspectives on integrating hemodialysis into a new life regarding self-participation experience. A qualitative study using the grounded theory method was applied. Thirty-two well-adaptive hemodialysis Taiwanese patients attended in-depth interviews. “Integrating hemodialysis into a new life journey” was identified as the core category guiding the entire self-participation experience of hemodialysis patients. The three antecedent themes were “Sense of worthlessness”, “Life is still worth living”, and “Friendly and joyful atmosphere of the hemodialysis room”. Once the patients went through the three antecedent themes, they gradually began making efforts to participate more fully in their hemodialysis. Within this participation experience, the hemodialysis patients exhibited these four interactive themes: “Overcoming one’s predicament”, “Integrating self-care skills into my life”, “Resuming previous roles and tasks”, and “Adapting to independent living”. Finally, most adaptive patients master the hemodialysis life. Encouraging patients to discover that their life is worth living and providing a friendly and joyful atmosphere in hemodialysis units are the keys to facilitating patients’ self-participation more fully.
Evaluation of a Non-Face-to-Face Multidisciplinary Health Care Model in a Population with Rheumatoid Arthritis Vulnerable to COVID-19 in a Health Emergency Situation
Authors: Santos-Moreno Pedro , Rodríguez-Vargas Gabriel-Santiago , Casanova Rosangela , Rubio-Rubio Jaime-Andrés , Chávez-Chávez Josefina , Rivera-Triana Diana , Castiblanco-Montañez Ruth , Hernández-Zambrano Sandra , Villareal Laura , Rojas-Villarraga Adriana
Published: December 2021

This study evaluated a non-face-to-face-multidisciplinary consultation model in a population with rheumatoid arthritis (RA) during the COVID-19 pandemic. This is an analytical observational study of a prospective cohort with simple random sampling. RA patients were followed for 12 weeks (Jul–Oct 2020). Two groups were included: patients in telemedicine care (TM), and patients in the usual face-to-face care (UC). Patients could voluntarily change the care model (transition model (TR)). Activity of disease, quality of life, disability, therapeutic adherence, and self-care ability were analyzed. Bivariate analysis was performed. A qualitative descriptive exploratory study was conducted. At the beginning, 218 adults were included: (109/TM-109/UC). The groups didn’t differ in general characteristics. At the end of the study, there were no differences in TM: (n = 71). A significant (p < 0.05) decrease in adherence, and increase in self-care ability were found in UC (n = 18) and TR (n = 129). Seven patients developed COVID-19. Four categories emerged from the experience of the subjects in the qualitative assessment (factors present in communication, information and communication technologies management, family support and interaction, and adherence to treatment). The telemedicine model keeps RA patients stable without major differences compared to the usual care or mixed model.
The Association between Chronic Hemodialysis and Toe Pinch Force in Japanese Patients: Cross-Sectional Study
Authors: Kataoka Hiroaki , Miyatake Nobuyuki , Matsuda Naoko , Hikasa Yasuaki , Kitayama Naomi , Nagai Shion , Tanaka Satoshi
Published: December 2021

The purpose of this cross-sectional study was to investigate the effect of chronic hemodialysis on toe pinch force (TPF). A total of 37 chronic hemodialysis patients without type 2 diabetes mellitus (T2DM) (age: 69.4 ± 11.8 years, duration of hemodialysis: 3.5 ± 3.4 years) were enrolled in this study. The TPF in chronic hemodialysis patients without T2DM was compared with that in 34 apparently healthy participants and 37 chronic hemodialysis patients with T2DM. There was no significant difference in clinical profiles between healthy participants and chronic hemodialysis patients with and without T2DM. The TPF in chronic hemodialysis patients without T2DM was lower compared with that in healthy participants (2.70 ± 1.05 kg vs. 3.34 ± 0.99 kg, p = 0.025). In addition, the TPF in patients with T2DM was even lower compared with that in patients without T2DM (2.12 ± 1.01 kg vs. 2.70 ± 1.05 kg, p = 0.042). This study showed a dramatic reduction in TPF in chronic hemodialysis patients, especially in those with T2DM.
Factors Influencing Self-Reported Medication Use in the Survey of Health Aging and Retirement in Europe (SHARE) Dataset
Authors: Schönenberg Aline , Prell Tino
Published: December 2021

The validity of self-reported medication use in epidemiological studies is an important issue in healthcare research. Here we investigated factors influencing self-reported medication use for multiple diagnoses in the seventh wave of the Survey of Health Aging and Retirement in Europe (SHARE) dataset in n = 77,261 participants (ages: mean = 68.47, standard deviation = 10.03 years). The influence of mental, physical, and sociodemographic parameters on medication self-report was analyzed with logistic regressions and mediation models. Depression, memory function, and polypharmacy influenced the self-report of medication use in distinct disorders to varying degrees. In addition, sociodemographic factors, knowledge about diagnosis, the presence of several chronic illnesses, and restrictions of daily instrumental activities explained the largest proportion of variance. In the mediation model, polypharmacy had an indirect effect via depression and memory on self-reported medication use. Factors influencing medication self-report vary between different diagnoses, highlighting the complexity of medication knowledge. Therefore, it is essential to assess the individual parameters and their effect on medication behavior. Relying solely on medication self-reports is insufficient, as there is no way to gage their reliability. Thus, self-reported medication intake should be used with caution to indicate the actual medication knowledge and use.
The Mediation Effect of Health Literacy on Social Support with Exchange and Depression in Community-Dwelling Middle-Aged and Older People in Taiwan
Authors: Shih Ya-Ling , Hsieh Chia-Jung , Lin Ya-Ting , Wang Yi-Zhu , Liu Chieh-Yu
Published: December 2021

The proportion of the world’s population that are over 60 years old is increasing rapidly. The physical and mental health of older people is affected by depression. Health literacy is a major determinant of health and healthcare for the aging; middle-aged and older people with high health literacy are more likely to maintain a healthy lifestyle, and control or manage their chronic diseases. Therefore, this study explored the relationship between health literacy, social support with exchange, and depression, in middle-aged and older adults in the community, using data from the 2015 Taiwan Longitudinal Study on Aging (TLSA) database. Of the 7636 participants, 1481 (19.4%) were middle-aged or older persons with depression symptoms. We found age, gender, and education level to be significantly related to health literacy status, social support with exchange, and depression. Health literacy was positively correlated with depression and social exchange in social support with exchange, whereas the emotional support component of social support with exchange was negatively correlated with depression. Regression-based process analysis was used to verify the mediation effect of health literacy. Our results indicated that when health literacy was entered into the regression model (a × b path), the effect of social exchange on depression was insignificant (c′ = −0.01, p = 0.84), indicating a complete mediation effect. These findings suggest that improving health literacy may offset the impact of social support with exchange on depression, and lead to the mitigation of depression in middle-aged and older people in Taiwanese communities.
Comparison of Mean Glandular Dose between Full-Field Digital Mammography and Digital Breast Tomosynthesis
Authors: Teoh Kar Choon , Manan Hanani Abdul , Mohd Norsuddin Norhashimah , Rizuana Iqbal Hussain
Published: December 2021

Early detection of breast cancer is diagnosed using mammography, the gold standard in breast screening. However, its increased use also provokes radiation-induced breast malignancy. Thus, monitoring and regulating the mean glandular dose (MGD) is essential. The purpose of this study was to determine MGD for full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) in the radiology department of a single centre. We also analysed the exposure factors as a function of breast thickness. A total of 436 patients underwent both FFDM and DBT. MGD was auto calculated by the mammographic machine for each projection. Patients’ data included compressed breast thickness (CBT), peak kilovoltage (kVp), milliampere-seconds (mAs) and MGD (mGy). Result analysis showed that there is a significant difference in MGD between the two systems, namely FFDM and DBT. However, the MGD values in our centre were comparable to other centres, as well as the European guideline (<2.5 mGy) for a standard breast. Although DBT improves the clinical outcome and quality of diagnosis, the risk of radiation-induced carcinogenesis should not be neglected. Regular quality control testing on mammography equipment must be performed for dose monitoring in women following a screening mammography in the future.
Effects of Personal Ability and Social Welfare on the Health of Rural-to-Urban Elderly Migrants: An Empirical Analysis from Jiangsu Province, China
Authors: Xu Xinglong , Cui Yupeng , Cai Yang , Asante Antwi Henry , Zhou Lulin , Bangura Joseph Noah
Published: December 2021

This study aims to discuss the relationship between personal endowment and social welfare on the health status of the rural-to-urban elderly migrants. It constructed the theoretical framework of the health vulnerability of rural-to-urban elderly migrants. The health status of rural-to-urban elderly migrants was divided into three dimensions: physical health, mental health, and social adaptation. A total of 658 rural-to-urban elderly migrants in 12 cities of Jiangsu province were selected as samples for empirical test and analyzed the influence of individual endowments and social welfare on the health status of rural-to-urban elderly migrants and their differences. The result shows that personal ability affects the social adaptation ability of rural-to-urban elderly migrants, and social welfare has a significant influence on the physical and mental health of rural-to-urban elderly migrants. Lacking the learning ability of rural-to-urban elderly migrants in sample areas is the main factor that leads to their low social adaptation ability and the unequal social welfare and public services restricting the physiological and mental health status of rural-to-urban elderly migrants.
WFD Ecological Quality Indicators Are Poorly Correlated with Water Levels in River Catchments in Tuscany (Italy)
Authors: Arrighi Chiara , Bonamini Isabella , Simoncini Cristina , Bartalesi Stefano , Castelli Fabio
Published: December 2021

The Water Framework Directive (WFD) requires European countries to achieve a good ecological status of surface water bodies and demands that River District Authorities define ecological flows consistently. Nevertheless, the relationship between ecological and hydrological indicators is not fully understood and not straightforward to apply because ecological and hydrological indicators are monitored by different institutions, with different timings and purposes. This work examines the correlation between a set of ecological indicators monitored by environmental agencies (STAR-ICMi, LIMeco, IBMR, and TDI) and water levels with assigned durations monitored by the hydrologic service in Tuscany (central Italy). Reference water levels are derived from stage-duration curves obtained by the statistical analysis of daily levels in the same year of ecological sampling. The two datasets are paired through a geospatial association for the same river reach and the correlation is measured through Pearson’s r. The results show poor correlation (r between −0.33 and −0.42) between ecological indicators and hydrologic variables, confirming the findings observed in other Italian catchments with different hydrologic regimes, climate, and anthropogenic pressures. Nevertheless, the negative correlations show a decreasing water quality with water depths, i.e., in the lower part of the catchments more affected by anthropogenic pressures. These findings suggests that the determination of ecological flows with a purely hydrological approach is not sufficient for achieving WFD objectives in the study area.
Correlation among Knee Muscle Strength and Self-Reported Outcomes Score, Anterior Tibial Displacement, and Time Post-Injury in Non-Coper Anterior Cruciate Ligament Deficient Patients: A Cross-Sectional Study
Authors: Manchado Ignacio , Alvarez David , Motta Luci M. , Blanco Gustavo , Saavedra Pedro , Garcés Gerardo L.
Published: December 2021

Little attention has been paid to knee muscle strength after ACL rupture and its effect on prognostic outcomes and treatment decisions. We studied hamstrings (H) and quadriceps (Q) strength correlation with a patient-reported outcome measures score (International Knee Documentation Committee, IKDC), anterior tibial translation (ATT), and time post-injury in 194 anterior cruciate ligament deficient patients (ACLD) who required surgery after a failed rehabilitation program (non-copers). The correlation between knee muscle strength and ATT was also studied in 53 non-injured controls. ACLD patients showed decreased knee muscle strength of both the injured and non-injured limbs. The median (interquartile range) values of the H/Q ratio were 0.61 (0.52–0.81) for patients’ injured side and 0.65 (0.57–0.8) for the non-injured side (p = 0.010). The median H/Q ratio for the controls was 0.52 (0.45–0.66) on both knees (p < 0.001, compared with the non-injured side of patients). The H/Q, ATT, and time post-injury were not significantly correlated with the IKDC score. ATT was significantly correlated with the H/Q of the injured and non-injured knees of patients, but not in the knees of the controls. Quadriceps strength and H/Q ratio were significantly correlated with ATT for both limbs of the patients. IKDC score correlated significantly with the quadriceps and hamstrings strengths of the injured limb but not with the H/Q ratio, ATT or time passed after injury.
Development and Validation of a Primary Care Electronic Health Record Phenotype to Study Migration and Health in the UK
Authors: Pathak Neha , Zhang Claire X. , Boukari Yamina , Burns Rachel , Mathur Rohini , Gonzalez-Izquierdo Arturo , Denaxas Spiros , Sonnenberg Pam , Hayward Andrew , Aldridge Robert W.
Published: December 2021

International migrants comprised 14% of the UK’s population in 2020; however, their health is rarely studied at a population level using primary care electronic health records due to difficulties in their identification. We developed a migration phenotype using country of birth, visa status, non-English main/first language and non-UK-origin codes and applied it to the Clinical Practice Research Datalink (CPRD) GOLD database of 16,071,111 primary care patients between 1997 and 2018. We compared the completeness and representativeness of the identified migrant population to Office for National Statistics (ONS) country-of-birth and 2011 census data by year, age, sex, geographic region of birth and ethnicity. Between 1997 to 2018, 403,768 migrants (2.51% of the CPRD GOLD population) were identified: 178,749 (1.11%) had foreign-country-of-birth or visa -status codes, 216,731 (1.35%) non-English-main/first-language codes, and 8288 (0.05%) non-UK-origin codes. The cohort was similarly distributed versus ONS data by sex and region of birth. Migration recording improved over time and younger migrants were better represented than those aged ≥50. The validated phenotype identified a large migrant cohort for use in migration health research in CPRD GOLD to inform healthcare policy and practice. The under-recording of migration status in earlier years and older ages necessitates cautious interpretation of future studies in these groups.
Assessment of the Carbon Emission Reduction Effect of the Air Pollution Prevention and Control Action Plan in China
Authors: Zhang Zhenhua , Zhang Jingxue , Feng Yanchao
Published: December 2021

In this study, we propose an integrated econometric framework incorporating the difference-in-differences model, the propensity-score-matching difference-in-differences model, and the spatial difference-in-differences model to explore the effect of the Air Pollution Prevention and Control Action Plan on per capita carbon emission in China at the national, regional, and administrative levels. Contradictory results are supported under different econometric models, which highlight the importance and necessity of comprehensive analysis. Taking 285 prefecture-level and above cities as an example, the empirical results show that APPCAP has effectively reduced per capita carbon emission in China at the national level without the consideration of the spatial spillover effect. However, with the consideration of the spatial spillover effect, APPCAP has effectively and directly increased per capita carbon emission in local pilot cities at the national level, and reduced it among pilot cities via the spatial spillover effect, but the effects have become invalid in the non-pilot cities neighboring the pilot cities. Furthermore, the spatial heterogeneity of the effects of APPCAP on per capita carbon emission are supported at the regional and administrative levels. Finally, some specific policy implications are provided for achieving the “win-win” situation of energy saving, emission reduction, and economic development.
The Significance of Short Latency in Mesothelioma for Attribution of Causation: Report of a Case with Predisposing Germline Mutations and Review of the Literature
Authors: Klebe Sonja , Hocking Ashleigh J. , Soeberg Matthew , Leigh James
Published: December 2021

Malignant mesothelioma is a tumour of the serosal membranes, related to asbestos exposure. Median latency is in the order of 40 years in various registries, but small numbers of cases with shorter latencies have long been reported and often dismissed as unrelated to asbestos exposure. However, emerging data regarding the significance of inherited mutations leading to a predisposition to mesothelioma suggest that the causative effect of asbestos may be associated with shorter latencies in a subset of patients. Here, we describe a male patient with germline mutations in RAD51 and p53 who developed peritoneal mesothelioma 8.5 years after well-documented asbestos exposure and discuss the current literature on the subject. Mesothelioma in situ is now a WHO-accepted diagnosis, but preliminary data reveal a potential lead time of 5 or more years to invasive disease, and this is also a factor which may affect the recording of latency (and potentially survival) in the future.
Dietary Intake, Cost, and Affordability by Socioeconomic Group in Australia
Authors: Lewis Meron , McNaughton Sarah A. , Rychetnik Lucie , Chatfield Mark D. , Lee Amanda J.
Published: December 2021

Few Australians consume diets consistent with the Australian Dietary Guidelines. A major problem is high intake of discretionary food and drinks (those not needed for health and high in saturated fat, added sugar, salt and/or alcohol). Low socioeconomic groups (SEGs) suffer particularly poor diet-related health. Surprisingly, detailed quantitative dietary data across SEGs was lacking. Analysis of the most recent national nutrition survey data produced habitual intakes of a reference household (two adults and two children) in SEG quintiles of household income. Cost and affordability of habitual and recommended diets for the reference household were determined using methods based on the Healthy Diets Australian Standardised Affordability and Pricing protocol. Low SEGs reported significantly lower intakes of healthy food and drinks yet similarly high intakes of discretionary choices to high SEGs (435 serves/fortnight). Total habitual diets of low SEGs cost significantly less than those of high SEGs (AU$751/fortnight to AU$853/fortnight). Results confirmed low SEGs cannot afford a healthy diet. Lower intakes of healthy choices in low SEGs may help explain their higher rates of diet-related disease compared to higher SEGs. The findings can inform potential policy actions to improve affordability of healthy foods and help drive healthier diets for all Australians.