bluuebunny/crossref_metadata_2025 huggingface dataset:
Top B2B sales strategies for household hygiene products in Sulaymaniyah
Authors: Mohammed Mohammed Ali
Published: November 2024

Aims: This market research has been conducted in Sulaymaniyah city, which emphasizes benchmarking top hygiene brands, evaluating the relationship among variables such as promotion, price, product quality, service quality, brand image, country image, customer value, customer satisfaction, switch intention and brand loyalty to design appropriate marketing strategies for businesses in hygiene and cleaning product market and also, assessing market owners' most important point of view on hygiene products.
Design: It is conducted through the benchmarking process of selling cleaning and hygiene products by B2B. All data are primary and collected from real markets and retailers, which are more than 101 brands in the Sulaymaniyah government. The collected data are analyzed with frequency and regression analyses to assess the strategic weight and importance of selling hygiene products.
Finding: From this research, market owners do not rely on promotion and price to decide whether to work on a brand. At the same time, service quality and product quality hurt brand image. In this case, it is discovered that brand owners have not done services correctly. It can be an opportunity to penetrate markets. However, packaging and online ordering systems are the most powerful factors impacting service quality. However, market owners do not trust products when they are introduced as high quality. Safety, performance, size aesthetics, durability, and usability are the most critical factors that affect product quality from a B2B perspective. Country of origin or country image negatively affects brand image because they believe that generally, products are imported from Turkey and Iran. Country image negatively affects customer value because customers do not trust products are imported from somewhere else apart from Iran and Turkey. By increasing brand image, the customer value rises and leads to customer satisfaction and eventually affects brand loyalty. In contrast, by increasing customer value, switch intention reduces and leads to better brand loyalty effectiveness.
CAR-IMMUNOTHERAPY IS A BREAKTHROUGH IN CELL BIOLOGY AND MEDICINE
Authors: TARASOV A.V. , KAZAKOV S.P. , MASENKO V.P. , GRINEV E.A.
Published: November 2024

The review article provides data on the introduction into practical healthcare of treatment methods based on the technology of using genetic products for the treatment of oncohematological and oncological diseases. The technology is based on immunotherapy using certain subpopulations of immunocompetent lymphocytes and embedded chimeric antigen receptors (CAR). The use of cytotoxicity properties of certain subpopulations of lymphocytes makes it possible to create drugs from them aimed at certain patterns of malignant cells. The article presents data starting from the concept of immunoredaction of solid tumors, describes the structure of the chimeric receptor, presents data on the technology of obtaining a chimeric receptor based on CAR-T lymphocytes and the features of the developed five generations of this drug (technology). The technological stages of T-lymphocyte therapy with chimeric antigen receptors for the treatment of patients are described. The authors focused on the description of the technology for obtaining a chimeric cellular receptor using libraries of retro- and lentivirus particles. The technological features based on the fundamental developments of scientists and biologists in obtaining vectors, the complexity of creating vectors and producing a chimeric receptor by a certain subpopulation of lymphocytes, new non-integrating lentiviral vectors and the use of revolutionary CRISPR/Cas9 technology for gene editing used in obtaining new generations of vectors are described. The authors elaborated on the technology of obtaining vectors from lentiviruses and new technological advances that are used to obtain vectors and subsequently create new variants of chimeric cellular receptors and products that are available on the world market. The experience of practical application of CAR therapy, mainly with T-lymphocytic clones with a chimeric antigen receptor in oncohematology and new promising directions for their use in the treatment of solid tumors, as well as in the treatment of autoimmune diseases and in organ and tissue transplantation are described. The prospects for immunotherapy with drugs with a chimeric antigen receptor of other subpopulations of immunocompeten cells, such as NK- and NKT lymphocytes, are presented.
A CLINICAL CASE OF LABORATORY DIAGNOSIS OF MALIGNANT HYPERTHERMIA
Authors: KARPOV V.O. , KAZAKOV S.P.
Published: November 2024

The article presents data on a rare case of malignant hyperthermia (MH) that occurred on the operating table in patient M. during routine treatment in a multifunctional hospital. Hematological, biochemical, and immunological laboratory analysis are presented, which were carried out to patient M. under suspicion of anesthesiologists at the beginning of the operation and allowed timely prevention of complications causing multiple organ failure and timely therapy to stop the symptoms of developing shock. Further molecular genetic studies revealed a mutation in the RYR1 gene, with the replacement of nucleotide bases G>C, which provided the basis for confirming this disease. The diagnostic algorithm draws attention to key laboratory indicators - a significant increase in creatinekinase to 1493 IU/l on the day of surgery and to 4376 IU/l in subsequent days, myoglobin more than 700 ng/ml, which exceeds the upper reference intervals by several dozen times, as well as a simultaneous increase in lactate levels to 3.1 mmol/l, a disorders of the acid-base state of the blood, manifested by acidosis up to 7,18 units, hypercapnia and an increase in buffer excess. This publication may be of interest to anesthesiologists, pathology and laboratory medicine doctors and other specialists in the clinic of surgical diseases and emergency medicine, as an example of identifying the cause and algorithms for confirming a preliminary diagnosis of MH or observed unusual changes in laboratory parameters during surgery. This laboratory data allow us to confirm the preliminary diagnosis of MH and begin a set of therapeutic measures to stop the complication
MONOCYTE DISTRIBUTION WIDTH - AN INNOVATIVE MARKER OF SEPSIS
Authors: KISHKUN A.A.
Published: November 2024

The search for simple and reliable laboratory biomarkers for diagnosing sepsis is one of the most important areas of scientific and practical research. Currently, among all sepsis biomarkers studied, laboratory parameters related to the complete clinical blood test (CBC) are of the greatest clinical value. Monocyte count and monocyte distribution width (MDW) are part of the CBC. MDW is an indicator that is quickly and automatically calculated by the latest generation of hematology analyzers. The study provides reference values for MDW and the results of the clinical use of MDW as a biomarker for the early detection of sepsis in patients.
ORGANIZATION OF CERVICAL CANCER SCREENING IN TAMBOV REGION
Authors: YEZHOVA E.N. , YEZHOVA E.V. , PAVLOVA S.I.
Published: November 2024

The authors present a description of a program designed to reduce the incidence and mortality from cervical cancer in the female population of the Tambov region by early detection of precancerous pathology using highly sensitive screening tests. The screening model for cervical cancer in the Tambov region includes the collection of cellular material from all women who are subject to medical examination at the age of 18 to 69 years, which is sent for analysis to a centralized clinical and cytological laboratory on the basis of the Tambov Regional Oncological Clinical Dispensary. To complete the program, the equipment was upgraded: BD SurePath systems for automatic preparation and staining of preparations, BD FocalPoint computerized screening systems, Hamamatsu high-tech slide scanner for scanning histological and cytological preparations were installed, Vision Cyto Pap automatic digital microscopy system was introduced. Digital preparations are separated in an automatic classification, and the data obtained is archived in cloud storage. The introduction of the liquid cytology method with a coverage of at least 80% allowed the Tambov region to become one of the leaders in Russia in detecting cervical cancer in the early stages. The authors believe that in order to enhance the effect of the screening program, active interaction of oncologists, gynecologists, midwives, primary care paramedics is necessary.
LABORATORY SERVICE OF PENZA REGION: HISTORY, PRESENT AND PRIORITY AREAS OF DEVELOPMENT
Authors: TOKAREVA E.V. , FURMAN O.L. , LEVASHOVA O.A.
Published: November 2024

The article presents the development of laboratory service of Penza region for 110 years of its formation. The foundation of laboratory service is considered to be 1913. For 110 years the laboratory service has passed all stages of formation, development and nowadays represents a powerful diagnostic complex, which performs the whole range of diagnostic tests. The article presents regional programmes in which laboratories of Penza region take part, priority directions of further development of the service are defined.
Memory, Identity, and Resistance: Jurek Becker's Narratives as social Commentary on Holocaust Trauma
Authors:   Indipendent Scholar, Rue Émilie Claus, 61. 1180, Belgium., Guglielmi Maddalena
Published: November 2024

This article examines the life and work of Jurek Becker, focusing on his unique perspective as a Holocaust survivor and his contributions to post-war German literature. Although Becker’s literary legacy remains largely within German borders, his novels - particularly Jakob the Liar - offer profound insights into the Holocaust and Jewish identity in the context of both Germanies. Born into a Jewish family and surviving the horrors of the Lodz ghetto and concentration camps, Becker’s writing reflects his ambivalence towards Jewish identity and his complex relationship with German society. This article explores Becker’s thematic focus on memory, loss, and the search for identity, revealing how his experiences shaped narratives that address universal themes of human resilience and suffering. By analyzing Becker’s novels, essays, and personal reflections, the article underscores his role in grappling with Germany's Nazi past and confronting themes of memory and belonging that resonate well beyond the GDR’s ideological confines.
A CUSTOM INTEGRATED KNOWLEDGE MANAGEMENT SYSTEM FRAMEWORK OVER CLOUD FOR AMU STAFF
Authors: Kesim Basha , Tuni Amin
Published: November 2024

Knowledge management is vital for universities like Arbaminch University (AMU) to stay competitive. However, managing and sharing knowledge effectively among university communities can be challenging. As one of the eight research universities in Ethiopia, AMU needs to be aware and provide the necessary knowledge management (KM) conditions to encourage staff on how to share knowledge in order to make existing knowledge accessible and generate new knowledge. However, there is a lack of means for AMU staff to share knowledge and collaborate virtually on different personnel and university tasks. Motivated by this, the researchers introduced suitable KM approaches that can enhance the collaboration and knowledge sharing among AMU staff. This research applied a design science approach using a mixed research method. The study investigated the current usage status of how AMU staff can collaborate and share knowledge. The results showed that 81% of respondents were not satisfied with the working environment towards the easy accessibility of knowledge sharing, as finding knowledge in the institution cannot be easily accessible at anytime and anywhere. Based on this reality and the staff's needs, the researchers finally developed a cloud-based integrative KM framework that was used to capture, represent, and share knowledge among AMU staff. The study concludes that if this developed KM framework is practiced continuously in the institution, all the vital knowledge could be captured, recorded, and preserved for future use, simplifying the transfer of knowledge to the next generation.
Keywords: Cloud-based, Integrative, Knowledge, Management, sharing, Collaboration, Explicit, Tacit
EFFECTIVENESS OF SELECTED LOW IMPACT DEVELOPMENT (LIDS) FOR SUSTAINABLE STORMWATER MANAGEMENT IN A FAST-URBANIZING RESIDENTIAL AREA
Authors: ADEOGUN Adeniyi Ganiyu , Sanni Abubakar , Ganiyu Habeeb Oladimeji
Published: November 2024

The alteration of natural land cover due to global urbanization has led to the creation of extensive impermeable surfaces, which hinder water infiltration and promote runoff from precipitation. This phenomenon adversely affects the natural environment and water quality. To address the issue of stormwater generation, this study utilized the Storm Water Management Model (SWMM) in conjunction with MAPWindow Geographical Information System (GIS) to simulate the impact of specific Low Impact Developments (LIDs) for mitigating stormwater in the study area. The study area was divided into six sub-basins within the GIS environment and imported into SWMM to assess the effects of selected LIDs, including green roofs, rain gardens, vegetative swales, and permeable pavements. The SWAT model was employed to predict the flow of water in the Malete watershed and the runoff on its surface. The study identified areas that were susceptible to erosion and were categorized as low, high, severe, and extreme. The results indicated that all LIDs simulated effectively reduced stormwater generation across the sub-basins. Notably, permeable pavements exhibited the highest reduction rate, reducing stormwater by approximately 50% across all sub-basins, whereas green roofs showed the lowest reduction rate of only 0.003%. Regional calibration was implemented and a significant correlation of 71% was observed between the simulated and observed flows in the study area. The findings of this study can serve as a valuable decision-support tool for various stakeholders and relevant authorities when selecting appropriate LID practices to mitigate the urban impact of stormwater generation.
GIS-based Land Suitability Analysis for Mung Bean Production in Arba Minch Zuria District, Gamo Zone, Southern Ethiopia
Authors: Alemu Mr. Adane , Toma Dr. Thomas , Uncha Dr. Abera
Published: November 2024

Land suitability analysis is of vital importance to maximize crop productivity of farming households. This study has aimed to investigate land suitability for mung bean production using the Analytical Hierarchic Process model. Four main criteria (soil, climate, land use land cover and topography), and 8 sub-criteria (slope, soil texture, soil depth, soil pH, soil cation exchange capacity, temperature, rainfall, and soil drainage) were selected to analyze land suitability. The sub-criteria were reclassified into 5 suitability levels: high, moderate, marginal, not suitable, and permanently not suitable. The Analytic Hierarchy Process (AHP), was used to determine the perceived weights that each criterion and sub-criteria carry. The land suitability for mung bean production during the October-November-December (OND) season showed by the final map was 32% (high), 26% (moderate), and 42% (marginal). 14%, 62%, and 24%, respectively were the suitability levels designated as high, moderate, and marginal during the January-February-March (JFM) season. Due to the prevalence of the climatic conditions, topography, spatially low lands, and fertile soil, the production of mung bean during the OND season was high. The major factors that impede higher land suitability during the JFM season include rainfall, soil, poor drainage, and slope. The production of mung bean is important in the agricultural sector for many benefits like human nutrition, local market, animal feed, export commodities, and soil fertility maintenance. So, stakeholders such as the district agricultural office, and governmental, and non-governmental actors should encourage farmers to produce more in conducive seasons and relieve food security shortfalls and livelihood problems in the entirety.  
Keywords: Land suitability; Geographic Information System; Analytical Hierarchic Process; Mung bean
The Water Quality Status of Washa and Borale Reservoirs Using both Water Quality Parameters and Macroinvertebrates in Ethiopian Central Highlands
Authors: Tamire Girum , Tadesse Bezuayehu , Hailemariam Mastewal , Moges Admasu
Published: November 2024

Washa and Borale reservoirs are important in regulating climatic and ecological conditions and providing various economic services. However, water quality and/or ecological health status of reservoirs has not yet been properly assessed in Ethiopia. Therefore, the main purpose of this study was to assess the water quality status of the Washa and Borale reservoirs/ wetlands located in North Shewa Zone of Ethiopian Central Highlands. Their water quality status was assessed using water physicochemical parameters and macroinvertebrates in December 2020 and November 2021. The results recorded from Washa Reservoir showed that the concentration of nitrate, phosphate, ammonia and silica on average was 69 µg/L, 53.52 µg/L, 188.86 µg/L and 14 µg/L, respectively. Similarly, the concentration of nitrate, phosphate, ammonia and silica obtained from Borale Reservoir on average was 43.5 µg/L, 32.6 µg/L, 50.0 µg/L and 109.8 µg/L, respectively. The concentration of ammonia was found to be high in both reservoirs indicating the presence of organic contamination. The total number of macroinvertebrates collected from Washa and Borale reservoirs were 519 and 789, respectively. Eight families belonging to three orders were recorded in Washa Reservoir whereas seven families belonging to four orders were recorded in Borale Reservoir. Order Hemiptera was represented by 5 families, Coleptera by two and Ephemeroptera by one in Washa Reservoir. Similarly, Hemiptera was represented by four families compared to other orders in Borale Reservoir. High dominance of tolerant macroinvertebrate families and absence of sensitive families indicated ecological instability and pollution in Borale Reservoir. Besides, ecological disturbance and pollution are observed in Washa Reservoir. Hence, human interference and cattle drinking should be regulated before both reservoirs are impaired permanently.
Keywords: Central Ethiopia, Evaluation, Wetlands, Water parameters, Water pollution
Analisis Pengelolaan Pajak Daerah dalam Meningkatkan Pendapatan Daerah pada Badan Pendapatan Daerah Kabupaten Kotawaringin Barat
Authors: Yaumil Yaumil , Tobarasi Indrawan , Darmanto Darmanto
Published: November 2024

Badan Pendapatan Daerah Kabupaten Kotawaringin Barat bertugas membantu Bupati dalam pengelolaan pendapatan daerah berdasarkan asas otonomi dan tugas pembantuan. Penelitian ini bertujuan untuk: (1) Menganalisis manajemen pengelolaan pajak daerah dalam meningkatkan pendapatan daerah, (2) Mengidentifikasi faktor pendukung peningkatan pendapatan daerah, dan (3) Mengevaluasi optimalisasi penerimaan pajak daerah di Kabupaten Kotawaringin Barat. Penelitian menggunakan metode kualitatif dengan pendekatan studi kasus untuk memahami secara mendalam pengelolaan pajak daerah dari berbagai aspek. Pengumpulan data dilakukan melalui wawancara dan dokumentasi, dengan informan terdiri dari pejabat Badan Pendapatan Daerah dan staf terkait. Data dianalisis melalui reduksi data, penyajian data, dan penarikan kesimpulan/verifikasi. Hasil penelitian menunjukkan bahwa realisasi penerimaan pajak daerah dari 2018 hingga 2023 tidak pernah mencapai target, meskipun pendapatan tahunan mengalami peningkatan. Pengelolaan pajak daerah berjalan baik dengan penerapan lima siklus, yaitu: identifikasi pendapatan, administrasi, koleksi, pencatatan, dan alokasi pendapatan. Faktor pendukung pengelolaan pajak daerah mencakup regulasi, sarana dan prasarana, sumber daya manusia, struktur organisasi, komitmen, dan konsistensi. Optimalisasi penerimaan pajak dilakukan melalui intensifikasi dan ekstensifikasi pajak daerah. Penelitian ini menyimpulkan bahwa meskipun manajemen pengelolaan pajak daerah sudah efektif, peningkatan target pendapatan belum tercapai, dan diperlukan upaya intensifikasi serta ekstensifikasi untuk lebih mengoptimalkan penerimaan pajak daerah.
Systematic Review: The Impact of Antimicrobial Stewardship Program Implementation in Hospital Intensive Care Units
Authors: Candra Tifany Maulida , Syafhan Nadia Farhanah , Kurniasih Fransisca Dhani
Published: November 2024

Antimicrobial resistance represents a significant challenge in clinical settings, particularly in intensive care units (ICUs). The incidence of antimicrobial resistance in the ICUs has reached 30% of all hospital patients. Furthermore, over 71% of patients on the unit were using antibiotics. Consequently, infections contribute substantially to the elevated mortality and morbidity rates in patients with critical status. The Antimicrobial Stewardship Program (ASP) is a program that refers to a multidisciplinary approach to optimize the appropriate use of antimicrobials. This systematic review aims to identify ASP policies implemented in hospital ICUs, utilizing various parameters for assessment. This systematic review was conducted using PubMed, Scopus, Google Scholar, and the Cochrane Database of Systematic Reviews, focusing on publications from January 1, 2015, to June 1, 2024. A comprehensive review of 4,419 articles identified 12 studies that met the inclusion and exclusion criteria. The primary goal of ASP is to enhance the appropriateness of antimicrobial use, ensuring accurate prescribing practices in terms of indication, antimicrobial selection, route of administration, and therapy duration. The outcomes of ASP implementation are evaluated based on decreased in antimicrobial use, increased in the number of recommendations, decreased in treatment costs, and a decrease in multidrug-resistant organism (MDRO) incidence. Although numerous articles have provided positive results regarding the implementation of ASP in ICU settings, there remains a need for extensive and structured research to validate these findings comprehensively.
The Position Of Commitment-Making Officials As Legal Subjects In Disputes Over Construction Service Agreements In Indonesian Courts
Authors: Marfungah Siti , Suartini Suartini
Published: November 2024

The role of the Commitment Making Officer (CMO) is crucial because they are responsible for the procurement process and contract implementation. However, disputes often occur regarding the CMO's legal position in the agreement. This study aims to examine in depth how courts in Indonesia view and regulate the legal position of CMO as a legal subject in the settlement of construction service agreement disputes. This study uses normative legal research methods with legislative and comparative approaches. The results showed that courts in Indonesia tend to position CMO as a legal subject that has significant responsibilities in construction service agreement disputes. CMOs are given the role of being responsible for the implementation of the contract and can be a party directly involved in dispute resolution in court. The analysis also reveals variations in the legal treatment of CMOs from case to case, highlighting the complexities in the interpretation and application of the relevant laws. Recommendations from this research include the need for further clarification in the legal regulations governing the position of CMOs, as well as the importance of better legal education regarding the responsibilities of CMOs in the context of construction service agreement disputes.
Identity Negotiation And Resistance In The Short Story 'Rose In The Tiger Canal': A Review Of Feminism Poscocolonial
Authors: Rosita Eva , Yanti Prima Gusti
Published: November 2024

This study examines the negotiation of identity and female resistance in the short story Mawar di Kanal Macan by Iksaka Banu, focusing on the dual oppression faced by women in colonial and postcolonial contexts. Using a descriptive-analytical method and a postcolonial feminist approach, the research explores how colonial and patriarchal power structures shape women's identities and incite resistance. Drawing on theories of identity, subalternity, and hybridity, the analysis investigates how women in subaltern positions negotiate their identities within dominant power structures. Furthermore, it examines how hybridity and intersectionality create spaces for resistance through both subtle and overt actions. The findings reveal that the main character, Adelheid Ewald, navigates complex identity negotiations due to the intersecting influences of colonial and patriarchal dominance, with resistance manifesting in legal and symbolic forms. These insights contribute to postcolonial feminist discourse in Indonesia, offering a deeper understanding of how women assert their agency despite operating within layered systems of oppression. The study suggests further exploration of other literary works that engage similar themes to expand discussions on identity and resistance in postcolonial societies.
Eksplorasi Emosi dan Nilai Kolektivitas pada Cerita Fantasi “Kura-Kura dan Monyet” Serta “Kancil dan Kura-Kura” pada Buku Ajar Bahasa Indonesia Penerbit Erlangga
Authors: Ika Sulistiyarini Lia Metha Sevita , Umaya Nazla Maharani
Published: November 2024

Latar Belakang: Penelitian ini mengenai Kura-Kura dan Monyet serta Kancil dan Kura-Kura, sebagai sarana untuk memahami bagaimana cerita fantasi dapat menjadi media pembelajaran emosional dan sosial yang efektif bagi anak-anak.
Tujuan: Berangkat dari pendekatan mimetis, analisis ini melihat cerita fantasi sebagai cerminan kehidupan anak-anak, khususnya dalam pengembangan karakter dan dinamika sosial yang sering dialami dalam interaksi sehari-hari.
Metode: Kura-Kura dan Monyet berpusat pada konflik antara kerja keras dan keegoisan, yang menyampaikan pesan tentang pentingnya ketekunan dan kesabaran. Sementara itu, Kancil dan Kura-Kura menonjolkan nilai kolektivitas dan kerja sama dalam menghadapi tantangan, serta strategi cerdik untuk menyelesaikan konflik kelompok.
Hasil: Dari perspektif kehidupan anak-anak, cerita ini membuka wawasan tentang berbagai emosi yang dialami tokoh-tokohnya, mulai dari kesabaran, ketidakpuasan, hingga kesadaran diri. Hal ini mencerminkan dinamika emosi dan sosial yang penting bagi anak-anak dalam membangun empati, solidaritas, dan kemampuan berpikir kritis. Selain itu, cerita ini menggambarkan bagaimana sifat egois dan manipulatif berpengaruh negatif pada keharmonisan kelompok, mengajarkan anak-anak bahwa tindakan yang berbasis pada kebaikan dan kerjasama akan lebih dihargai dan berdampak positif.
Kesimpulan: Fabel berfungsi sebagai media hiburan sekaligus pembelajaran nilai moral yang mendukung perkembangan emosi dan sosial anak-anak. Cerita fantasi membantu memperkaya imajinasi anak sekaligus memperkuat karakter positif. Pendekatan ini relevan untuk mengajarkan nilai-nilai penting dalam pendidikan karakter di era modern. Fabel mencerminkan kehidupan emosional anak yang sering kali terabaikan oleh pembaca dewasa. Sastra ini berpotensi menjadi alat pendidikan karakter yang efektif dan menarik bagi anak-anak.
Solidarity strategies in adolescent communication
Authors: Rudneva Ekaterina A.
Published: November 2024

The study aims to reveal politeness strategies used in natural interaction within a particular community group. The article analyses excerpts from audio recordings of conversations of teenage male friends. The chosen interactional approach relies on Goffman’s notion of face and Brown and Levinson’s model of linguistic politeness, ethnographic methods of collecting data, and conversation analysis. The case study continues the discussion of gender and age aspects of politeness realization and communication styles. The article reveals the following interactional solidarity strategies: teasing and group jokes, where participants add details to exaggerate the comic effect; ritual insults, in particular making up nicknames; synchronized speech pacing, even leading to creating spontaneous poetry. In the case of a request, the following politeness strategies and means are noted: repetition of words, both literal and with variations; increasing the volume and varying the speech rate, which express the common emotional state; decreasing the imposition with lexical means, markers of in-group identity; friend’s supporting through an offer and a jokily threat, language game (rhyming and deliberate mispronouncing), politeness marker "please" and its slang equivalent “pazhe”, minimizing the degree of a favour; using markers of group identity (“brother”), offering help and threating jokingly, using puns (rhyme and deliberate change of the phonetic form of a word), and increasing volume and prosodic emphasis that express an emotional state. Participants experiment with communicative strategies, sometimes pushing the degree of their expression to the edge and turning it into a performance. Applying the solidarity strategies in a more expressive and playful way seems to be a feature of the adolescent communication style. The data analysed reveals the local, cultural (and supposedly age) specifics of employing the universal face-saving mechanism of the communication.
Desarrollo de aprendizajes disciplinares y transversales mediante proyectos STEAM
Authors: Echeverría Caranqui Jenniffer Pamela , Arévalo Cáceres Angel Edder
Published: November 2024

La metodología STEAM (ciencia, tecnología, ingeniería, arte y matemáticas) está centrada en la resolución de problemas y brinda una perspectiva general de temas relacionados con diferentes disciplinas como ciencias y matemáticas, además favorece la interacción con los materiales y conceptos de STEAM y de sus componentes. El objetivo principal de este estudio fue la de analizar el impacto de los proyectos STEAM en el desarrollo de aprendizajes disciplinares y transversales en estudiantes de tercero de bachillerato técnico de la especialidad de instalaciones, equipos y máquinas eléctricas en la una institución educativa para realizarlo se llevaron a cabo ocho proyectos, cada uno diseñado para fortalecer tanto competencias específicas y transversales. Para llevar a cabo esta investigación de campo se aplicaron encuestas y entrevistas a 23 estudiantes obteniendo como resultado que los estudiantes el desarrollaron habilidades prácticas relevantes para su especialidad y dinámicas propias del entorno laboral, como la organización grupal, la gestión de proyectos y la solución de conflictos.
Un peligroso olvido: historia de los sismos en Veracruz
Authors:   Atarraya
Published: November 2024

por Gerardo Antonio Galindo Peláez y Hubonor Ayala Flores El devenir de las sociedades humanas está intrínsecamente ligado a los desastres, de ahí que resulta necesario abordar dicha relación en un diálogo entre el presente y el pasado, para comprender los alcances y consecuencias históricas de estos fenómenos.
How we built a database of preprints
Authors: Levchenko Maria
Published: November 2024

Finding preprints across many different platforms can be difficult. Here we explain how Europe PMC has built a database of life science preprints.
An analysis of the relationship between self-consciousness and eating attitudes among 8th grade students
Authors: Karaarslan Çayirpunar Safiye Övgü , Özden Tunca Özlem
Published: November 2024

This research investigates the relationship between eating attitudes and self-consciousness among 8th-grade students studying in the Kağıthane district of Istanbul during the 2023–2024 academic year. The study included a total of 568 students (300 males and 268 females). Participants were administered the Sociodemographic Form, Eating Attitudes Test (EAT-40), and the Self-Consciousness Scale. Data were analyzed using SPSS 27.0 software. Pearson correlation and multiple regression analysis were conducted to examine the predictive role of self-consciousness on eating attitudes. A positive relationship was found between “self-consciousness” and “eating attitude.” Independent sample t-tests and one-way ANOVA were used to compare groups based on sociodemographic variables. The eating attitudes score was significantly higher among female students compared to male students (t = −6.26; p < 0.001). Students with a family history of dieting had significantly higher eating attitude scores compared to those without (t = 4; p < 0.001). No significant differences were found based on screen usage during meals, meal procurement methods, meal companions, time spent at school, frequency of packaged food consumption, or parental restrictions on packaged foods. Self-consciousness scores were compared based on gender, diet history, household composition, number of siblings, meal companions, birth order, and parental restrictions on packaged foods. Female students had significantly higher scores in private self-consciousness (t = −3.96; p < 0.001), general self-consciousness (t = −9.37; p < 0.001), and social anxiety (t = −7.51; p < 0.001) compared to male students. Students with a diet history had significantly higher general self-consciousness scores (t = 2.39; p < 0.05) compared to those without. No significant differences were found in self-consciousness levels based on household composition, number of siblings, meal companions, birth order, or parental restrictions on packaged foods. For future scientific studies, the findings were discussed, and suggestions were provided.
A brief review on basic fundamentals of nanoparticle (NPs)
Authors: Mohapatra Subhasri , Sahu Bhishm Kumar , Dash Deepak Kumar
Published: November 2024

According to studies made by previous researchers there are various technical problems associated with liposomes which can be avoided by designing colloidal drugs carrier like nanoparticles with nanotechnology. Now a days they are beneficial in the field of agriculture, veterinary, pharmaceutical, textile technologies. Site specific delivery of encapsulated drugs can be formulated with a nanometer size range which can be injected into the general circulation. The objective of this review is to explain the potential of NPs and nanotechnology associated with their characters and classifications, synthesis and application as the emerging scopes for NPs, rather will attract everyone’s attention. The aim of the present work is to characterize biodegradable nanoparticulate systems for oral controlled release, while numerous publications have appeared on this by international research teams, the research on polymeric nanoparticles has been primarily performed by a few research groups in Europe. Nanoparticles are being investigated as an alternative colloidal drug delivery system that could potentially avoid some of the technical problems observed with other drug delivery system.
Pengembangan Aplikasi Deteksi Sumber Air Tanah Menggunakan Metode Sensor Kapasitif
Authors: Ketut Doni Riyan Dinata  , Tata Sutabri
Published: November 2024

The decline in the quality and quantity of groundwater resources is one of the biggest challenges in natural resource management in many areas. Mapping the potential of groundwater requires technology that can identify and detect the presence of water sources with high accuracy. The purpose of this study is to develop a groundwater detection application using a capacitance-based remote sensing method, which leverages the principle of capacitance changes on the soil surface due to the presence of groundwater. The capacitance sensing method was chosen because it can detect differences in capacitance between water-filled soil and dry soil. In this study, we integrate a capacitive sensor connected to electronic devices into a mobile application to visualize and analyze the data in real-time. This application aims to enable users, such as farmers and researchers, to easily monitor and detect the presence of groundwater sources at various locations with high efficiency.
Metastatic giant pleomorphic retroperitoneal liposarcoma in a pregnant woman with HIV: A case report
Authors: Busra A. Ahmed , Yusuf A. Khalil , Doreen N. Wekesa , Onesmus Gachuno
Published: November 2024

Background: Liposarcomas and leiomyosarcomas are the most common histological types of retroperitoneal sarcomas, followed by undifferentiated soft tissue sarcomas in adults.Case presentation: A 38-year-old, gravida 4 para 3 HIV-positive, presented at 13 weeks of gestation to the antenatal ward as a referral with an ultrasound diagnosis of a retroperitoneal mass. Abdominal examination revealed a tender, firm mass in the left upper quadrant, extending to the left flank and fixed to the underlying structures. The abdomen's magnetic resonance imaging revealed a large soft tissue mass in the left retroperitoneum, with local invasion suggestive of a soft tissue sarcoma. She was put on analgesics, antiemetics, intravenous fluids, and total parenteral nutrition, with a plan for an ultrasound- guided biopsy of the mass and exploratory laparotomy. Her condition deteriorated, and subsequently arrested and succumbed eighteen days postadmission. The histological analysis of the postmortem specimen revealed a pleomorphic metastatic liposarcoma.Conclusion: Retroperitoneal liposarcomas are rare and often present a diagnostic and treatment challenge. Therefore, a high index of suspicion should be indicated in women who present with abdominal masses.
Retained fetal bones causing recurrent per vaginal discharge and secondary infertility: A case report
Authors: Corrine Arara , Sumayya M. Badamana , James Amenge
Published: November 2024

Background: Retained fetal bones as a cause of infertility is uncommon. Treatment involves removal of the fetal bones, with resolution of symptoms and resumption to fertility reported.Case presentation: A 31-year-old para 0+1 presented to the gynecological outpatient clinic with a two-year history of secondary infertility and recurrent vaginal discharge that begun following a pregnancy loss at 22 weeks gestation. She had undergone labor induction, after which she was scheduled twice for evacuation of retained products of conception. She was managed for vaginal discharge until a repeat scan revealed retained fetal parts and uterine fibroids a year later. Myomectomy was done, and fetal bones embedded in the myometrium and within the uterine cavity were removed.Conclusion: Retained fetal bones diagnosis should be entertained in patients presenting with a history of per vaginal discharge or secondary infertility following a miscarriage. The role of pelvic scan and hysteroscopy in evaluating these patients cannot be over-emphasized.
Intracranial subdural hematoma after spinal anesthesia for cesarean section: A case report
Authors: Mutwiri Kelvin , Mulunda Tapson
Published: November 2024

Background: Intracranial subdural hematoma (ISH) is a known but rare complication of spinal anesthesia that mainly presents with persistent headaches.Case presentation: A 35-year-old gravida 2 para 2 presented to the outpatient clinic with a history of headaches, dizziness, and vomiting for two days after an elective cesarean section under spinal anesthesia 20 days prior. Brain magnetic resonance imaging (MRI) revealed bilateral subdural hematomas. She was scheduled for burr hole craniotomy and was discharged five days post-evacuation. She presented seven days later with a two-day history of convulsions and headaches. A computed tomography scan revealed recurrent bilateral subdural hematomas that were evacuated via repeat burr hole craniotomy. Postoperatively, she developed blurred vision, diplopia, slurred speech, and episodes of loss of balance. A repeat MRI showed satisfactory clearance of the hematomas before discharge.Conclusion: A high index of suspicion for ISH should be indicated in patients with severe and persistent headaches after spinal anesthesia not relieved by conservative treatment, especially with the onset of other neurological symptoms.
Central precocious puberty secondary to pituitary microadenoma: A case report
Authors: Njiru Lydia W. , Wekesa Doreen N. , Golicha Zainab D. , Kosgei Rose J. , Gichuhi Joseph W.
Published: November 2024

Background: Precocious puberty is early pubertal development that results in future short stature and psychosocial problems.Case presentation: A four-and-a-half-year-old presented to the gynecology clinic with a history of two menstrual cycles. She had pubic hair growth and adult body odor six months prior to the occurrence of menses. She complained of on and off headacheswith blurry vision. The wrist radiograph for age assessment revealed that her age corresponded to the female standard number 18; the skeletal age was 10. The magnetic resonance imaging (MRI) of the brain (pituitary protocol) revealed a pituitary microadenoma. A diagnosis of central precocious puberty secondary to pituitary microadenoma was made. She was put on leuprolide 11.25 mg administered intramuscularly every three months with repeat investigations at six months. Her dose of leuprolide was changed to 15 mg three-monthly. Brain MRI two years since the initiation of treatment revealed that the microadenoma had completely resolved.Conclusion: Central precocious puberty is rare and therefore requires a high index of suspicion. Thorough workup and a multidisciplinary team are essential for its diagnosis and management.
Serum anti-Müllerian hormone as a predictor of metaphase II oocyte yield during controlled ovarian stimulation
Authors: Koigi Mary K. , Kosgei Rose J. , Kihara Anne-B , Kamau Reuben K. , Koigi Paul K.
Published: November 2024

Background: The potential to predict metaphase II (MII) oocyte yield in controlled ovarian stimulation (COS) has not been elucidated, despite being a mandatory predictor of fertilization potential. Hence this area is marred by the diversity of approaches to ovarian stimulation and the deficiency of standards.
Objective: To determine the role of serum anti-Müllerian hormone (AMH) as a predictor of MII oocyte yield during controlled ovarian stimulation at a private fertility clinic in Nairobi.Methods: A retrospective descriptive cohort study design was employed in which MII outcomes during COS were compared among women aged 18-45 years with normal or low serum AMH levels. Data were collected sequentially until the desired sample size was achieved. Data were analyzed using the IBM statistical package for social sciences (SPSS) version 24.0 and STATA version 15. The level of significance was set at p<0.05.Results: Approximately one-third of women above 35 years of age had normal serum AMH levels, while nearly three-quarters had low serum AMH levels (OR=0.1; 95 CI (0.1–0.4); p-value<0.001). By day % five, hyperresponse was more preponderant among those with normal AMH levels (39.0 vs. 3.8 ; % % OR=15.9; CI (2.0-126.0); p-value<0.001) and remained consistent. Almost three quarters of women with low AMH levels had a low MII yield compared to nearly one-quarter of those with normal AMH levels (OR=0.3; 95 CI (0.1-0.8); p- % value=0.014), even after controlling for age. This trend was consistent with that of the total oocyte count. The sensitivity, specificity, and positive and negative predictive values of serum AMH level as a predictor of MII oocyte yield were 86.0 , 54.3 , % % 72.96 , and 73.1 , respectively. % %Conclusion: Normal serum anti-Müllerian hormone levels is associated with increased follicular count and total oocyte harvest during controlled ovarian stimulation and is a good predictor of MII oocyte yield.
Phyllodes tumor, cardiovascular and chronic renal disease in a young lady on hormone replacement therapy: A case report
Authors: Mengesa Lauryn , Dido Daki , Muchiri Dorcus , Owende Philomena
Published: November 2024

Background: Hormonal replacement therapy (HRT) has been associated with anincreased risk of developing breast cancer. The level of risk varies with different types ofHRT and the duration of use. Phyllodes tumor accounts for less than 1% of all breastneoplasms and is associated with Li-Fraumeni syndrome.Case presentation: A 37-year-old nulliparous woman presented with a left breast lump.Histological examination revealed a spindle cell neoplasm consistent with a malignantphyllodes tumor. She was diagnosed at age of 12 with ovarian dysgerminoma, hadsubtotal hysterectomy and right oophorectomy, radiotherapy and chemotherapy. Shehas been on HRT with conjugated equine estrogens for 13 years and tibolone for thelast 5 years. Following the diagnosis of phyllodes tumor, a mastectomy was performed,and HRT was changed to vaginal estrogen gel.Conclusion: Hormonal replacement therapy may pose a risk for certain types of breastcancer, especially with prolonged use of combined therapy. Patients who developcancers early in life, as well as those on HRT, require close follow-up and adequatepatient education with an emphasis on self-breast examination. Sensitization ofhealthcare providers and patients on the value of genetic screening would facilitateearly identification of such patients and follow-up at high-risk clinics.
Cryoneurolysis is a Safe and Effective Method for Reducing Perioperative Pain in Total Knee Arthroplasty
Authors: Manes Taylor J , Walker Jamison , Ricken Rileigh , Gupta Nithin , Turnow Morgan , Asad Shaheryar , Dykhouse Gabrielle , Miller James D.
Published: November 2024

Introduction: Pain management following total knee arthroplasty (TKA) is crucial for patient care and recovery. While opioid analgesics have traditionally been used, concerns over their adverse effects and the opioid epidemic have driven exploration of alternative pain management strategies. Multimodal (MM) pain control, targeting multiple pain pathways, has emerged as a promising approach, encompassing various medications and administration routes. Cryoneurolysis, a non-opioid therapy, has garnered attention for its potential in acute pain management, including its use before and after TKA.

Methods: This study is a systematic review aiming to evaluate the efficacy and safety of cryoneurolysis as a method for managing perioperative pain in TKA. Primary outcomes include a reduction in opioid consumption and length of hospital stay, while secondary outcomes encompass functional and pain-related scores.

Results: Seven of 434 studies met inclusion criteria. Published between 2016 and 2023, these included five retrospective studies and two randomized controlled trials, involving a total of 794 patients (38.3% male, 61.7% female). Most studies had a clearly defined control group, and the mean age of participants was approximately 66.6 years. The methodological assessment indicated a moderate to low risk of bias. Results demonstrated that cryoneurolysis reduced opioid consumption and improved pain and functional outcomes compared to control groups, including shorter hospital stays, improved range of motion, and pain score improvements.

Conclusion: Cryoneurolysis presents a promising option, with evidence suggesting its potential to reduce opioid consumption and improve patient outcomes in the face of an opioid epidemic. However, challenges and barriers to its widespread use remain, including technical complexities and the need for further high-quality evidence.