bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility of Probing the Filler Restructuring in Magnetoactive Elastomers by Ultra-Small-Angle Neutron Scattering
Authors: Belyaeva Inna A. , Klepp Jürgen , Lemmel Hartmut , Shamonin Mikhail
Published: May 2021

Ultra-small-angle neutron scattering (USANS) experiments are reported on isotropic magnetoactive elastomer (MAE) samples with different concentrations of micrometer-sized iron particles in the presence of an in-plane magnetic field up to 350 mT. The effect of the magnetic field on the scattering curves is observed in the scattering vector range between 2.5 × 10−5 and 1.85 × 10−4 Å−1. It is found that the neutron scattering depends on the magnetization history (hysteresis). The relation of the observed changes to the magnetic-field-induced restructuring of the filler particles is discussed. The perspectives of employing USANS for investigations of the internal microstructure and its changes in magnetic field are considered.
Integrated Photonics on Glass: A Review of the Ion-Exchange Technology Achievements
Authors: Broquin Jean-Emmanuel , Honkanen Seppo
Published: May 2021

Ion-exchange on glass is one of the major technological platforms that are available to manufacture low-cost, high performance Planar Lightwave Circuits (PLC). In this paper, the principle of ion-exchanged waveguide realization is presented. Then a review of the main achievements observed over the last 30 years will be given. The focus is first made on devices for telecommunications (passive and active ones) before the application of ion-exchanged waveguides to sensors is addressed.
Prediction of Post-Yield Performance of Hybrid Precast Beams Based on Strength Degradation
Authors: Hong Won-Kee , Lim Gyun-Taek
Published: May 2021

In this study, the post-yield load-displacement relationships of precast composite beams with various boundary conditions were predicted based on strength degradation data. The aim of this study was to explore the post-yield hysteretic structural behavior of precast composite concrete beams based on stiffness degradation, which was calculated by normalizing effective stiffness with respect to stiffness at the yield limit state. The influence of degradation of the effective stiffness on the post-yield behavior of the specimens was investigated with extensive test data gathered using gauge measurements. The hysteresis behavior, determined from cyclic tests of full-scale composite specimens under the various boundary conditions, was used to predict the post-yield deflection of the composite beams. This paper collected post-yield test data for 13 specimens, including five pre-stressed specimens, to investigate the influence of pre-stressing forces on the post-yield characteristics of steel-concrete composite beams. The prediction of post-yield load-displacement relationships of the composite beams was based on six steps and matched well with test data, verifying the proposed analytical procedures for estimating post-yield performance. The post-yield load-displacement relationships of precast composite concrete beams were satisfactorily predicted by the simplified but convenient method.
Adaptability of Buildings: A Critical Review on the Concept Evolution
Authors: Askar Rand , Bragança Luís , Gervásio Helena
Published: May 2021

Our ever-evolving built environment is continuously facing emerging needs for housing, work, health, and mobility, among others. Yet, buildings are usually designed and set up as finished permanent objects, reflecting the one constant scenario in mind of defined form, function, and performance. Since change is increasingly inevitable in our life, enlarging buildings’ adaptive capacities in response to arising variables and changing conditions over their lifecycle becomes a necessity in seeking global sustainability demands. The concept of building adaptability has been a notable subject in this respect, increasingly stimulating and proposing regenerative alternatives to today’s often obsolete buildings. This paper critically reviews the existing body of knowledge on the concept of adaptability in building research. The main focus is made on the evolution of the concept interpretations and related paradigms, and on the development of its applications and strategies in the light of promoting models and trends. Drawing on the literature as a source of evidence, the paper analyzes and classifies the content of existing studies published in scientific journals and gray literature, focusing on a timeframe from 2015 up-to-date. Moreover, the paper aims to build a constructive discussion to identify potential gaps between the actual state of the art and emerging needs, which should be addressed by further research.
The Basis for Reliability-Based Mechanical Properties of Structural Aluminium Alloys
Authors: Skejić Davor , Dokšanović Tihomir , Čudina Ivan , Mazzolani Federico M.
Published: May 2021

Adequate knowledge of mechanical properties and their statistical description is the basis for performing reliable verification of design methods and design of structures in general. The probabilistic design approach implemented in Eurocodes requires statistical data on all variables used in the design procedure. Although aluminium was introduced in structural Eurocodes more than four decades ago (ENV), the statistical database of mechanical properties is still inadequate. To provide a reliable statistical background, data collection was performed concerning aluminium products mainly found in the European market, within the last 20 years regarding certificates from the aluminium industry and 30 years regarding data from the research community. The collected data include aluminium alloy series 1xxx, 5xxx, 6xxx, and 7xxx, mainly extruded, and relevant mechanical properties such as 0.2% proof strength, ultimate strength, Young’s modulus, and Poisson’s ratio. They were fit to distributions, and relevant fractiles were determined, along with an analysis of nominal to characteristic and design value ratios. Variation of ratios obtained shows that that the majority of nominal values are economical and reliable. However, certain adjustments to nominal values are required to achieve a uniform reliability level in terms of the choice of alloy and temper.
Conflict Resolution in Mechatronic Collaborative Design Using Category Theory
Authors: Fradi Mouna , Mhenni Faïda , Gaha Raoudha , Mlika Abdelfattah , Choley Jean-Yves
Published: May 2021

Due to the multitude of disciplines involved in mechatronic design, heterogeneous languages and expert models are used to describe the system from different domain-specific views. Despite their heterogeneity, these models are highly interrelated. As a consequence, conflicts among expert models are likely to occur. In order to ensure that these models are not contradictory, the necessity to detect and manage conflicts among the models arises. Detecting these inconsistencies at an early stage significantly reduces the amount of engineering activities re-execution. Therefore, to deal with this issue, a formal framework relying upon mathematical concepts is required. The mathematical theory, namely category theory (CT), is considered as an efficient tool to provide a formal and unifying framework supporting conflict detection and management. This paper proposes a comprehensive methodology that allows conflict detection and resolution in the context of mechatronic collaborative design. CT is used in order to explicitly capture the inconsistencies occurred between the disparate expert models. By means of this theory, the conflicts can be detected and handled in an easy and formal way. Our proposed approach is applied to a collaborative scenario concerning the electro-mechanical actuator (EMA) of the aileron.
Wine Experiences: A Review from a Multisensory Perspective
Authors: Campo Raffaele , Reinoso-Carvalho Felipe , Rosato Pierfelice
Published: May 2021

The existing multisensory literature suggests that the combination of the different human senses in a controlled fashion during food/drink experiences can provide more enjoyment to consumers. The present research reviews recent literature relating multisensory perception with wine experiences, focusing on the interaction of the five basic senses (taste, smell, vision, touch, and sound). This is mostly being assessed from a perceptual and behavioral consumer perspective. Here, the authors report different ways in which such interactions across these senses can affect the way a wine is experienced, prior to, during, and even after tasting. The authors finish this literature review by providing some insights in the context of wine and food pairing, while also generally reflecting on potential future work. These insights may be inspirational for a diverse group of organizations working with wine. Based on such multisensory approaches, it may be possible to bring unforeseen sensations to the different wine experiences, while at the same time stressing particular sensory and/or emotional attributes.
Performance Calculations of Gas Turbine Engine Components Based on Particular Instrumentation Methods
Authors: Catană Răzvan Marius , Dediu Gabriel , Tărăbîc Cornel Mihai , Șerbescu Horațiu Mihai
Published: May 2021

This paper presents an analytical method to determine various main parameters or performances of engine components when those parameters cannot be directly measured and it is necessary to determine them. Additionally, some variants of instrumentation methods are presented, for example: engine inlet, compressor, turbine or jet nozzle instrumentation. The purpose of the instrumentation methods is to directly measure the possible parameters, which are then used as inputs in a model to determine other parameters or performance metrics. This model is based on gasodynamic process equations, and it is used to compute the air and gas parameters, such as enthalpy and entropy, which are described in polynomial form, thus leading to a more realistic calculation. At the end, this paper presents a practical example of instrumentation applied on a Klimov TV2-117A turboshaft, with a series of experimental results, following the engine testing on the test bench.
Semantic Segmentation of Cabbage in the South Korea Highlands with Images by Unmanned Aerial Vehicles
Authors: Jo Yongwon , Lee Soobin , Lee Youngjae , Kahng Hyungu , Park Seonghun , Bae Seounghun , Kim Minkwan , Han Sungwon , Kim Seoungbum
Published: May 2021

Identifying agricultural fields that grow cabbage in the highlands of South Korea is critical for accurate crop yield estimation. Only grown for a limited time during the summer, highland cabbage accounts for a significant proportion of South Korea’s annual cabbage production. Thus, it has a profound effect on the formation of cabbage prices. Traditionally, labor-extensive and time-consuming field surveys are manually carried out to derive agricultural field maps of the highlands. Recently, high-resolution overhead images of the highlands have become readily available with the rapid development of unmanned aerial vehicles (UAV) and remote sensing technology. In addition, deep learning-based semantic segmentation models have quickly advanced by recent improvements in algorithms and computational resources. In this study, we propose a semantic segmentation framework based on state-of-the-art deep learning techniques to automate the process of identifying cabbage cultivation fields. We operated UAVs and collected 2010 multispectral images under different spatiotemporal conditions to measure how well semantic segmentation models generalize. Next, we manually labeled these images at a pixel-level to obtain ground truth labels for training. Our results demonstrate that our framework performs well in detecting cabbage fields not only in areas included in the training data but also in unseen areas not included in the training data. Moreover, we analyzed the effects of infrared wavelengths on the performance of identifying cabbage fields. Based on the results of our framework, we expect agricultural officials to reduce time and manpower when identifying information about highlands cabbage fields by replacing field surveys.
Spatial Characteristics of Precipitation in the Greater Sydney Metropolitan Area as Revealed by the Daily Precipitation Concentration Index
Authors: Cheung Kevin K. W. , Rasuly Aliakbar A. , Ji Fei , Chang Lisa T.-C.
Published: May 2021

In this study; the spatial distribution of the Daily Precipitation Concentration Index (DPCI) has been analyzed inside the Greater Sydney Metropolitan Area (GSMA). Accordingly, the rainfall database from the Australian Bureau of Meteorology archive was utilized after comprehensive quality control. The compiled data contains a set of 41 rainfall stations indicating consistent daily precipitation series from 1950 to 2015. In the analysis of the DPCI across GSMA the techniques of Moran’s Spatial Autocorrelation has been applied. In addition, a cross-covariance method was applied to assess the spatial interdependency between vector-based datasets after performing an Ordinary Kriging interpolation. The results identify four well-recognized intense rainfall development zones: the south coast and topographic areas of the Illawarra district characterized by Tasman Sea coastal regions with DPCI values ranging from 0.61 to 0.63, the western highlands of the Blue Mountains, with values between 0.60 and 0.62, the inland regions, with lowest rainfall concentrations between 0.55 and 0.59, and lastly the districts located inside the GSMA with DPCI ranging 0.60 to 0.61. Such spatial distribution has revealed the rainstorm and severe thunderstorm activity in the area. This study applies the present models to identify the nature and mechanisms underlying the distribution of torrential rains over space within the metropolis of Sydney, and to monitor any changes in the spatial pattern under the warming climate.
Novel Integrated and Optimal Control of Indoor Environmental Devices for Thermal Comfort Using Double Deep Q-Network
Authors: Kim Sun-Ho , Yoon Young-Ran , Kim Jeong-Won , Moon Hyeun-Jun
Published: May 2021

Maintaining a pleasant indoor environment with low energy consumption is important for healthy and comfortable living in buildings. In previous studies, we proposed the integrated comfort control (ICC) algorithm, which integrates several indoor environmental control devices, including an air conditioner, a ventilation system, and a humidifier. The ICC algorithm is operated by simple on/off control to maintain indoor temperature and relative humidity within a defined comfort range. This simple control method can cause inefficient building operation because it does not reflect the changes in indoor–outdoor environmental conditions and the status of the control devices. To overcome this limitation, we suggest the artificial intelligence integrated comfort control (AI2CC) algorithm using a double deep Q-network(DDQN), which uses a data-driven approach to find the optimal control of several environmental control devices to maintain thermal comfort with low energy consumption. The suggested AI2CC showed a good ability to learn how to operate devices optimally to improve indoor thermal comfort while reducing energy consumption. Compared to the previous approach (ICC), the AI2CC reduced energy consumption by 14.8%, increased the comfort ratio by 6.4%, and decreased the time to reach the comfort zone by 54.1 min.
In Pursuit of the Perfect Dancer’s Ballet Foot. The Footprint, Stabilometric, Pedobarographic Parameters of Professional Ballet Dancers
Authors: Gorwa Joanna , Michnik Robert , Nowakowska-Lipiec Katarzyna
Published: May 2021

This work aims to assess footprint parameters in a group of professional ballet dancers and to determine the correlation between the aforementioned parameters and lateralization, stabilometric parameters, pedobarographic parameters and work environment conditions. A group subjected to tests consisted of 44 elite professional ballet dancers and the reference group was composed of 44 students. The test of balance and thrust under feet involved 30 s-long free standing with open eyes on a podographic platform. The research-related analysis was concerned with footprint parameters (foot length and width, Clarke angle, and Weissflog index), stabilometric parameters (path length and ellipse field, mean value of the velocity and deflection of the displacement of the center of the foot pressure on the ground) and pedobarographic parameters (percentage thrust on the right, left foot as well as the front and rear part the foot). Statistically significant differences between the groups were observed in relation to the stabilometric parameters, the percentage pressure of the left forefoot and the right heel, as well as the value of the Clarke angle (p ≤ 0.05). The longitudinal arch of the foot and the width of the foot in ballet dancers are not dependent on the total and professional career duration and weekly training volume
Dynamics of Matrix Metalloproteinase-1 and -8 Secretion in Gingival Crevicular Fluid after Gingival Recession Therapy via MCAT with Either Subepithelial Connective Tissue Graft or Collagen Matrix
Authors: Skurska Anna , Dymicka-Piekarska Violetta , Milewski Robert , Pietruska Małgorzata
Published: May 2021

Objectives: The objective of this study was to determine and estimate the changing levels of matrix metalloproteinases 1 and 8 (MMP-1 and MMP-8) in GCF at consecutive stages of healing after root coverage procedure via modified coronally advanced tunnel (MCAT) combined with either sub-epithelial connective tissue graft (SCTG) or collagen matrix (CM) and also to relate those changes to clinical outcomes of both therapeutic approaches. Materials and methods: The study involved 20 patients with a total of 91 recessions. Those on one side of the mandible received MCAT plus CM while the contralateral ones MCAT plus SCTG. The evaluation of MMP-1 and MMP-8 concentrations in Gingival Crevicular Fluid (GCF) took place at baseline, then at 1, 2, and 4 weeks, and finally at 3 months after surgery. Elisa protocol was applied to determine the levels of MMP-1 and MMP-8 in GCF. Results: Three-month observation revealed statistically significant changes in MMP-1, MMP-8 and Sulcus Fluid Flow Rate (SFFR) values after implementation of both techniques. A correlation was found between a difference in MMP-1 concentrations and gain in Keratinized Tissue (KT) after SCTG and CM. MMP-8 levels and a Gingival Thickness (GT) gain observed after CM was also correlated. Conclusions: A type of augmentative material does appear to determine the dynamics of MMP-1 secretion.
Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies
Authors: Flynn Loren L. , Mitrpant Chalermchai , Adams Abbie , Pitout Ianthe L. , Stirnweiss Anja , Fletcher Sue , Wilton Steve D.
Published: May 2021

The literature surrounding the use of antisense oligonucleotides continues to grow, with new disease and mechanistic applications constantly evolving. Furthermore, the discovery and advancement of novel chemistries continues to improve antisense delivery, stability and effectiveness. For each new application, a rational sequence design is recommended for each oligomer, as is chemistry and delivery optimization. To confirm oligomer delivery and antisense activity, a positive control AO sequence with well characterized target-specific effects is recommended. Here, we describe splice-switching antisense oligomer sequences targeting the ubiquitously expressed human and mouse SMN and Smn genes for use as control AOs for this purpose. We report two AO sequences that induce targeted skipping of SMN1/SMN2 exon 7 and two sequences targeting the Smn gene, that induce skipping of exon 5 and exon 7. These antisense sequences proved effective in inducing alternative splicing in both in vitro and in vivo models and are therefore broadly applicable as controls. Not surprisingly, we discovered a number of differences in efficiency of exon removal between the two species, further highlighting the differences in splice regulation between species.
Stretchable Capacitive Pressure Sensing Sleeve Deployable onto Catheter Balloons towards Continuous Intra-Abdominal Pressure Monitoring
Authors: Senthil Kumar Kirthika , Xu Zongyuan , Sivaperuman Kalairaj Manivannan , Ponraj Godwin , Huang Hui , Ng Chi-Fai , Wu Qing Hui , Ren Hongliang
Published: May 2021

Intra-abdominal pressure (IAP) is closely correlated with intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) diagnoses, indicating the need for continuous monitoring. Early intervention for IAH and ACS has been proven to reduce the rate of morbidity. However, the current IAP monitoring method is a tedious process with a long calibration time for a single time point measurement. Thus, there is the need for an efficient and continuous way of measuring IAP. Herein, a stretchable capacitive pressure sensor with controlled microstructures embedded into a cylindrical elastomeric mold, fabricated as a pressure sensing sleeve, is presented. The sensing sleeve can be readily deployed onto intrabody catheter balloons for pressure measurement at the site. The thin and highly conformable nature of the pressure sensing sleeve captures the pressure change without hindering the functionality of the foley catheter balloon.
The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder
Authors: Georgitsi Marianthi , Dermitzakis Iasonas , Soumelidou Evgenia , Bonti Eleni
Published: May 2021

Specific Learning Disorder (SLD) is a multifactorial, neurodevelopmental disorder which may involve persistent difficulties in reading (dyslexia), written expression and/or mathematics. Dyslexia is characterized by difficulties with speed and accuracy of word reading, deficient decoding abilities, and poor spelling. Several studies from different, but complementary, scientific disciplines have investigated possible causal/risk factors for SLD. Biological, neurological, hereditary, cognitive, linguistic-phonological, developmental and environmental factors have been incriminated. Despite worldwide agreement that SLD is highly heritable, its exact biological basis remains elusive. We herein present: (a) an update of studies that have shaped our current knowledge on the disorder’s genetic architecture; (b) a discussion on whether this genetic architecture is ‘unique’ to SLD or, alternatively, whether there is an underlying common genetic background with other neurodevelopmental disorders; and, (c) a brief discussion on whether we are at a position of generating meaningful correlations between genetic findings and anatomical data from neuroimaging studies or specific molecular/cellular pathways. We conclude with open research questions that could drive future research directions.
New Approach for Untangling the Role of Uncommon Calcium-Binding Proteins in the Central Nervous System
Authors: Kelemen Krisztina , Szilágyi Tibor
Published: May 2021

Although Ca2+ ion plays an essential role in cellular physiology, calcium-binding proteins (CaBPs) were long used for mainly as immunohistochemical markers of specific cell types in different regions of the central nervous system. They are a heterogeneous and wide-ranging group of proteins. Their function was studied intensively in the last two decades and a tremendous amount of information was gathered about them. Girard et al. compiled a comprehensive list of the gene-expression profiles of the entire EF-hand gene superfamily in the murine brain. We selected from this database those CaBPs which are related to information processing and/or neuronal signalling, have a Ca2+-buffer activity, Ca2+-sensor activity, modulator of Ca2+-channel activity, or a yet unknown function. In this way we created a gene function-based selection of the CaBPs. We cross-referenced these findings with publicly available, high-quality RNA-sequencing and in situ hybridization databases (Human Protein Atlas (HPA), Brain RNA-seq database and Allen Brain Atlas integrated into the HPA) and created gene expression heat maps of the regional and cell type-specific expression levels of the selected CaBPs. This represents a useful tool to predict and investigate different expression patterns and functions of the less-known CaBPs of the central nervous system.
Facial Expression-Based Experimental Analysis of Human Reactions and Psychological Comfort on Glass Structures in Buildings
Authors: Bedon Chiara , Mattei Silvana
Published: May 2021

For engineering applications, human comfort in the built environment depends on several objective aspects that can be mathematically controlled and limited to reference performance indicators. Typical examples include structural, energy and thermal issues, and others. Human reactions, however, are also sensitive to a multitude of aspects that can be associated with design concepts of the so-called “emotional architecture”, through which subjective feelings, nervous states and emotions of end-users are evoked by constructional details. The interactions of several objective and subjective parameters can make the “optimal” building design challenging, and this is especially the case for new technical concepts, constructional materials and techniques. In this paper, a remote experimental methodology is proposed to explore and quantify the prevailing human reactions and psychological comfort trends for building occupants, with a focus on end-users exposed to structural glass environments. Major advantages were taken from the use of virtual visual stimuli and facial expression automatic recognition analysis, and from the active support of 30 volunteers. As shown, while glass is often used in constructions, several intrinsic features (transparency, brittleness, etc.) are responsible for subjective feelings that can affect the overall psychological comfort of users. In this regard, the use of virtual built environments and facial expression analysis to quantify human reactions can represent an efficient system to support the building design process.
Genetic Diagnosis in Sudden Cardiac Death: The Crucial Role of Multidisciplinary Care
Authors: van der Crabben S. N. , Komdeur F. L. , Nossent E. J. , Deprez R. H. Lekanne , Broekhuizen E. A. , van der Werf C. , Vermeer A. M. C. , Niessen H. W. M. , Houweling A. C.
Published: May 2021

Sudden death, especially at a young age, may be caused by an underlying genetic cause. Hereditary conditions with an increased risk of sudden death at a young age include cardiomyopathies, arrhythmia syndromes, and hereditary thoracic aortic aneurysms and dissections. The identification of a genetic cause allows for genetic testing and cardiological surveillance in at-risk relatives. Three sudden death cases from our hospital illustrate the value of autopsy, genetic, and cardiological screening in relatives following a sudden death. On autopsy, histology consistent with hereditary cardiomyopathy is a reason for the referral of relatives. In addition, in the absence of an identifiable cause of death by autopsy in young sudden death patients, arrhythmia syndrome should be considered as a potential genetic cause.
Alternative Routes for the Production of Natural 4-Vinylguaiacol from Sugar Beet Fiber Using Basidiomycetous Enzymes
Authors: Günther Thorben , Schoppe Lasse , Ersoy Franziska , Berger Ralf G.
Published: May 2021

Traditional smoking generates not only the impact flavor compound 4-vinylguaiacol, but concurrently many unwanted and potent toxic compounds such as polycyclic aromatic hydrocarbons. Enzyme technology provides a solution without any side-product formation. A feruloyl esterase from Rhizoctonia solani (RspCAE) liberated ferulic acid from low-priced sugar beet fiber. Decarboxylation of ferulic acid to 4-vinylguaiacol was achieved by a second enzyme from Schizophyllum commune (ScoFAD). Both enzymes were covalently immobilized on agarose to enable reusability in a fixed-bed approach. The two enzyme cascades showed high conversion rates with yields of 0.8 and 0.95, respectively, and retained activity for nearly 80 h of continuous operation. The overall productivity of the model process with bed volumes of 300 µL and a substrate flow rate of 0.25 mL min−1 was 3.98 mg 4-vinylguaiacol per hour. A cold online solid phase extraction using XAD4 was integrated into the bioprocess and provided high recovery rates during multiple elution steps. Attempting to facilitate the bioprocess, a fused gene coding for the two enzymes and a set of different linker lengths and properties was constructed and introduced into Komagataella phaffii. Longer and rigid linkers resulted in higher activity of the fusion protein with a maximum of 67 U L−1.
Characterization and Structure Elucidation of Binary Zr:Ti MEL Structure; Simultaneous Photodegradation/Removal of Organic–Inorganic Pollutants
Authors: Kosa Samia A. , Abd El Maksod Islam H. , Hegazy Eman Z. , Al-sebaii Naha M.
Published: May 2021

The preparation of a series of different Ti/Zr MEL structure was performed successfully. Full characterization of the prepared materials was done using XRD, IR, DR, and SEM. The results show that the prepared materials contain only one crystalline phase (ZSM-11). The affinity of Zr to form the crystalline phase alone in a binary Zr/Ti synthesizing mixture was approved by SEM and elemental analysis results. The percentage of each active site was calculated. DR spectra were deconvoluted, and three active sites were supposed and quantified (tetragonal, octahedral, and crystalline). The mutual effect of ions (lead, copper, cobalt, and nickel) and methylene blue dye on the removal efficiency with and without ultraviolet irradiation was examined and fully characterized. The ions largely influence the photodegradation process, and a mechanism was formulated. Meanwhile, the presence of dye showed a negligible effect on the removal of ions.
The Emerging Role of CT-Based Imaging in Adipose Tissue and Coronary Inflammation
Authors: Yuvaraj Jeremy , Cheng Kevin , Lin Andrew , Psaltis Peter J. , Nicholls Stephen J. , Wong Dennis T. L.
Published: May 2021

A large body of evidence arising from recent randomized clinical trials demonstrate the association of vascular inflammatory mediators with coronary artery disease (CAD). Vascular inflammation localized in the coronary arteries leads to an increased risk of CAD-related events, and produces unique biological alterations to local cardiac adipose tissue depots. Coronary computed tomography angiography (CTA) provides a means of mapping inflammatory changes to both epicardial adipose tissue (EAT) and pericoronary adipose tissue (PCAT) as independent markers of coronary risk. Radiodensity or attenuation of PCAT on coronary CTA, notably, provides indirect quantification of coronary inflammation and is emerging as a promising non-invasive imaging implement. An increasing number of observational studies have shown robust associations between PCAT attenuation and major coronary events, including acute coronary syndrome, and ‘vulnerable’ atherosclerotic plaque phenotypes that are associated with an increased risk of the said events. This review outlines the biological characteristics of both EAT and PCAT and provides an overview of the current literature on PCAT attenuation as a surrogate marker of coronary inflammation.
Inflammation and Atherosclerosis
Authors: Ley Klaus
Published: May 2021

This 11-chapter Special Issue of Cells spans the gamut from basic science in mechanistic animal models to translational science to outcomes of clinical trials, all focused on the role of inflammation in atherosclerosis [...]
Photoluminescent Metal Complexes and Materials as Temperature Sensors—An Introductory Review
Authors: Kenney John W. , Lee Jae Joon
Published: May 2021

Temperature is a fundamental physical quantity whose accurate measurement is of critical importance in virtually every area of science, engineering, and biomedicine. Temperature can be measured in many ways. In this pedagogically focused review, we briefly discuss various standard contact thermometry measurement techniques. We introduce and touch upon the necessity of non-contact thermometry, particularly for systems in extreme environments and/or in rapid motion, and how luminescence thermometry can be a solution to this need. We review the various aspects of luminescence thermometry, including different types of luminescence measurements and the numerous materials used as luminescence sensors. We end the article by highlighting other physical quantities that can be measured by luminescence (e.g., pressure, electric field strength, magnetic field strength), and provide a brief overview of applications of luminescence thermometry in biomedicine.
Potentiometric Electronic Tongue for Pharmaceutical Analytics: Determination of Ascorbic Acid Based on Electropolymerized Films
Authors: Broncová Gabriela , Prokopec Vadim , Shishkanova Tatiana V.
Published: May 2021

This work deals with the design of an experimental potentiometric electronic tongue (ET) for the recognition of various samples of effervescent tablets with different ascorbic acid (vitamin C) contents. The ET consisted of twelve potentiometric sensors based on conductive polymers, which were derived from 4-amino-2,1,3-benzothiadiazole, 3,4-diaminobenzoic acid, and neutral red on the surface of the platinum electrode using cyclic voltammetry. The aim of the potentiometric study was to assess the influence of the vitamin C content and the composition of the matrix of commercial samples on the potentiometric response. The results obtained from the sensor array proved that the stability of the potentiometric signal and the accuracy of measurements are affected by individual sensors. The identification of the vitamin C content in the individual samples of effervescent tablets obtained by means of the potentiometric electronic tongue corresponded with the results of the coulometric titration.
Pediatric Subcutaneous Abscess: Still a Clinical Exam-Based Diagnosis and Treatment
Authors: Garcia Isabel C. , Clark Rachael A. , Chung Dai H. , Gaines Nakia
Published: May 2021

Subcutaneous abscesses occur frequently in the pediatric population, yet there is great variability in the approach to diagnosis and management, partly due to opposing recommendations in the current literature and the lack of a standardized protocol for diagnosis and management among pediatric medical centers. This has led to inconsistencies by the providers, as well as the hospital clinical pathways, with regards to the appropriate management of subcutaneous abscesses. We hypothesize that the current variability in diagnostic work-up and management contributes to the wide use of unnecessary imaging and therapeutics without altering the overall outcomes. We performed a retrospective chart review that compared 200 encounters for patients < 18 years of age with a diagnosis of subcutaneous abscess at a single large tertiary pediatric institution. Our results showed that only 13.6% of wound cultures obtained led to a change in the antibiotic regimen and that blood cultures were positive in only 2.1% of cases. There was no difference in the incision and drainage performed based on ultrasound findings in the presence of fluctuance on physical exam. Patients presenting with fever were more likely to be admitted to the hospital for further care than those without fever. Our results showed no difference in outcome after incision and drainage for abscesses packed with gauze versus those left to drain via a vessel loop drain. There was no difference in recurrence in patients discharged with oral antibiotics versus without oral antibiotic treatment. Our data indicate that many of the diagnostic studies used for the management of a subcutaneous abscess have little to no effect on the outcome. Subcutaneous abscesses are a common pediatric complaint, and this study could help healthcare providers utilize more effective and efficient management strategies for skin and soft tissue infections.
Risk Factors of Growth Retardation and Developmental Deficits in Very Preterm Infants in a German Tertiary Neonatal Unit
Authors: Lademann Hanne , Janning Anna , Müller Josephyn , Neumann Luisa , Olbertz Dirk , Däbritz Jan
Published: May 2021

Over the last two decades, improvements in perinatology have led to increased survival rates of preterm infants. A large number of studies and meta-analyses have investigated of preterm infants and/or the influence of developmental care. However, the combined influence of the most frequent risk factors and developmental care on the long-term somatic, motor, and cognitive outcome of preterm infants remains unclear. This retrospective, single-center cohort study includes 256 children treated in a tertiary neonatal intensive care unit in Rostock, Germany, between 2008 and 2013. Follow-up examinations (somatic, psychomotor, and mental development) were performed at (corrected) 24 months using Bayley Scales of Infant Development II (BSID-II). Developmental care was carried out according to the legal framework and national guidelines (physiotherapy and/or early education). Bronchopulmonary dysplasia (BPD) and an exclusive formula feeding showed a 2.8–4.6-fold higher risk (95% Confidence Interval: Mental Developmental Index 1.73–7.58; Psychomotor Developmental Index 1.44–14.54; body length 1.20–6.41) for developmental deficits (mental and psychomotor developmental index; body length). Developmental care after discharge according to national guidelines did not prevent this. Since this is a retrospective pilot study, no recommendations can be made based on this analysis. Therefore, future research should evaluate whether standard developmental care should be extended by tailored measures depending on individual risk factors.
Growth and Weight Status in Chinese Children and Their Association with Family Environments
Authors: Tian Xu , Wang Hui
Published: May 2021

The growth status and weight status of Chinese children have experienced remarkable changes in the past decades. Using China Health and Nutrition Survey (CHNS) data, this paper examines the secular trends and disparity of the growth status and weight status in Chinese children and further investigates the impact of various family environments on children’s growth from 1991 to 2011. We found an increasing trend in standardized growth indicators (height, weight, and BMI), overweight, and obesity from 1991 to 2011. We also observed an increasing disparity in overweight and obesity over time. Family environments had a significant impact on children’s growth status and weight status. In particular, children that live in families with a small size, higher family income, better sanitary conditions, and with well-educated parents or overweight parents tended to be taller and heavier and have a higher BMI, lower risk of being underweight, and higher risk of exhibiting overweight and obesity. Further decomposition analysis showed that more than 70% of the disparity in standardized height, weight, and overweight and around 50% of the disparity in standardized BMI, underweight, and obesity could be attributed to heterogeneity in family environments. Moreover, the disparity associated with family environments tended to increase over time.
Characterizing the Mechanism of Action of Essential Oils on Skin Homeostasis—Data from Sonographic Imaging, Epidermal Water Dynamics, and Skin Biomechanics
Authors: de Andrade Sérgio Faloni , Rijo Patricia , Rocha Clemente , Zhu Lin , Rodrigues Luis Monteiro
Published: May 2021

Essential oils (EOs) have been recognized as materials of interest for dermatological applications, although some doubts remain regarding their safety and efficacy. We studied the action mechanisms of EOs from lavender and sage in human skin. Extracted EOs were incorporated (at 5% and 10%) in almond oil as a vehicle. Eleven healthy volunteers were selected and the prepared oils were tested on both forearms. All procedures respected the principles of good clinical practice. Effects were followed through high resolution sonography (HRS), epidermal water dynamics, and biomechanics. All variables were measured before and 30 min after application. Nonparametric statistical comparisons were applied (p < 0.05). HRS revealed a more echogenic epidermis, with a significant echogenicity decrease in the dermis (higher water retention) for all formulations. Significant TEWL decrease and an increase in superficial and deep epidermal hydration were also observed. These results indicate that EOs penetrate only into the most superficial layers of the skin, which is important for their safety profile. Furthermore, this “filmogenic” mechanism improving the epidermal water balance seems to connect directly with the observed biomechanical enhancement. These results confirm the clinical relevance of these compounds, in particular to restore the epidermal water content and prevent xerosis and other related disorders in sensitive (atopic, elderly) patients.
Comparative Efficacy of Fractional CO2 Laser and Q-Switched Nd:YAG Laser in Combination Therapy with Tranexamic Acid in Refractory Melasma: Results of a Prospective Clinical Trial
Authors: Beyzaee Amir Mohammad , Patil Anant , Goldust Mohamad , Moslemi Marjan , Kazeminejad Armaghan , Rokni Ghasem Rahmatpour
Published: May 2021

Melasma manifests as hyperpigmented macules and patches, usually affecting the face, neck, and rarely upper limbs. This study evaluated comparative efficacy of a fractional CO2 laser with a Q-Switched Nd:YAG laser in combination therapy with tranexamic acid in refractory melasma. A total of 30 patients with refractory melasma were included in this study. The fractional CO2 laser (power: 30 w, pulse energy: 30 mJ, tip type: 300, pulse rate: 100/cm2) was used on one side of the patients’ face and three passes of the Q-Switched Nd:YAG (QSNY) laser (Wavelength: 1064 nm, pulse energy: 750 mJ, fluence: 1.50  J/cm2, spot size: 4 mm × 4 mm, hand piece: fractional) were used on the opposite side of the same patient’s face for six sessions. During the course of laser therapy, all patients received oral tranexamic acid 250 mg twice daily. Melasma area and severity index (MASI) score and physician’s satisfaction and patient’s satisfaction were analyzed. Thirty patients (mean age 39.97) were included. Patient global assessment (PtGA) in the fractional CO2 laser group was significantly better than the Q-Switched Nd:YAG laser group at 4th, 8th and 12th weeks (p-value < 0.001). According to PtGA, the improvement was significant in both groups over time. Physician global assessment (PGA) at the 8th and 12th weeks, and physician satisfaction (PS) at the 8th week, in the fractional CO2 laser group was significantly better than the Q-Switched Nd:YAG laser group (p-value < 0.05). The PGA in both groups significantly reduced over time. The MASI score significantly decreased in both groups over time. The MASI score in the fractional CO2 laser group decreased more than the Q-Switched Nd:YAG laser group over time (p < 0.001). The most common side effects reported were erythema and discomfort, which subsided in less than 24 h. A fractional CO2 laser with oral tranexamic acid is an effective and well tolerated therapeutic method for the treatment of patients with refractory melasma.
A Systematic Study of Compositionally Dependent Dielectric Tensors of SnSxSe1-x Alloys by Spectroscopic Ellipsometry
Authors: Nguyen Xuan Au , Nguyen Thi Minh Hai , Kim Tae Jung , Le Long Van , Nguyen Tung Hoang , Kim Bogyu , Kim Kyujin , Lee Wonjun , Cho Sunglae , Kim Young Dong
Published: May 2021

We report the dielectric tensors on the cleavage plane of biaxial SnSxSe1-x alloys in the spectral energy region from 0.74 to 6.42 eV obtained by spectroscopic ellipsometry. Single-crystal SnSxSe1-x alloys were grown by the temperature-gradient method. Strongly anisotropic optical responses are observed along the different principal axes. An approximate solution yields the anisotropic dielectric functions along the zigzag (a-axis) and armchair (b-axis) directions. The critical point (CP) energies of SnSxSe1-x alloys are obtained by analyzing numerically calculated second derivatives, and their physical origins are identified by energy band structure. Blue shifts of the CPs are observed with increasing S composition. The fundamental bandgap for Se = 0.8 and 1 in the armchair axis arises from band-to-band transitions at the M0 minimum point instead of the M1 saddle point as in SnS. These optical data will be useful for designing optoelectronic devices based on SnSxSe1-x alloys.
Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases
Authors: Flörke Christian , Gülses Aydin , Altmann Christina-Randi , Wiltfang Jörg , Wieker Henning , Naujokat Hendrik
Published: May 2021

The current study aimed to examine the effects of clinicopathological factors, including the region, midline involvement, T classification, histological grade, and differentiation of the tumor on the rate of contralateral lymph node metastasis for oral squamous cell carcinoma and to assess their effects on survival rates. A total of 331 patients with intraoral squamous cell carcinomas were included. The influence of tumor location, T status, midline involvement, tumor grading, and the infiltration depth of the tumor on the pattern of metastasis was evaluated. Additionally, the effect of contralateral metastases on the prognosis was examined. Metastases of the contralateral side occurred most frequently in squamous cell carcinomas of the palate and floor of the mouth. Furthermore, tumors with a high T status resulted in significantly higher rates of contralateral metastases. Similarly, the midline involvement, tumor grading, existing ipsilateral metastases, and the infiltration depth of the tumor had a highly significant influence on the development of lymph node metastases on the opposite side. Oral squamous cell carcinomas require a patient-specific decision. There is an ongoing need for further prospective studies to confirm the validity of the prognostic factors described herein.
The Great Mime: Three Cases of Melanoma with Carcinoid-Like and Paraganglioma-Like Pattern with Emphasis on Differential Diagnosis
Authors: Cazzato Gerardo , Colagrande Anna , Cimmino Antonietta , Demarco Aurora , Lospalluti Lucia , Arezzo Francesca , Resta Leonardo , Ingravallo Giuseppe
Published: May 2021

Melanoma is among the most aggressive tumors, with different histological patterns of presentation ranging from the usual and easily diagnosable pictures to complex patterns of difficult diagnostic interpretation. Here, we present three cases of a very rare melanoma variant described as “carcinoid-like” and “paraganglioma-like” in the literature, and a brief review of the current literature of the very few cases described to date.
Automated AI-Driven CT Quantification of Lung Disease Predicts Adverse Outcomes in Patients Hospitalized for COVID-19 Pneumonia
Authors: Chabi Marie Laure , Dana Ophélie , Kennel Titouan , Gence-Breney Alexia , Salvator Hélène , Ballester Marie Christine , Vasse Marc , Brun Anne Laure , Mellot François , Grenier Philippe A.
Published: May 2021

The purpose of our work was to assess the independent and incremental value of AI-derived quantitative determination of lung lesions extent on initial CT scan for the prediction of clinical deterioration or death in patients hospitalized with COVID-19 pneumonia. 323 consecutive patients (mean age 65 ± 15 years, 192 men), with laboratory-confirmed COVID-19 and an abnormal chest CT scan, were admitted to the hospital between March and December 2020. The extent of consolidation and all lung opacities were quantified on an initial CT scan using a 3D automatic AI-based software. The outcome was known for all these patients. 85 (26.3%) patients died or experienced clinical deterioration, defined as intensive care unit admission. In multivariate regression based on clinical, biological and CT parameters, the extent of all opacities, and extent of consolidation were independent predictors of adverse outcomes, as were diabetes, heart disease, C-reactive protein, and neutrophils/lymphocytes ratio. The association of CT-derived measures with clinical and biological parameters significantly improved the risk prediction (p = 0.049). Automated quantification of lung disease at CT in COVID-19 pneumonia is useful to predict clinical deterioration or in-hospital death. Its combination with clinical and biological data improves risk prediction.