bluuebunny/crossref_metadata_2025 huggingface dataset:
De l'« ab-sens » : Lacan et Wittgenstein
Authors: Rigal-Granel Élisabeth
Published: October 2013

Lacan a croisé Wittgenstein, mais il n’a connu que le Tractatus logico-philosophicus et s’est attaché à ses seuls aspects logiques. La contribution de ce texte poursuit un double objectif : déterminer les attendus du débat que Lacan a engagé avec Wittgenstein sur la question du métalangage ; établir que l’ineffable wittgensteinien n’est pas stricto sensu un ineffable au sens propre et qu’il présente certaines analogies avec l’« ab-sens » dont parle Lacan dans « L’étourdit ».
Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase–Dependent Inflammation
Authors: Bhowmick Rudra , Tin Maung Nang H. , Hurley Bryan P. , Ghanem Elsa Bou , Gronert Karsten , McCormick Beth A. , Leong John M.
Published: October 2013

Acute pulmonary infection by Streptococcus pneumoniae is characterized by high bacterial numbers in the lung, a robust alveolar influx of polymorphonuclear cells (PMNs), and a risk of systemic spread of the bacterium. We investigated host mediators of S. pneumoniae-induced PMN migration and the role of inflammation in septicemia following pneumococcal lung infection. Hepoxilin A3 (HXA3) is a PMN chemoattractant and a metabolite of the 12-lipoxygenase (12-LOX) pathway. We observed that S. pneumoniae infection induced the production of 12-LOX in cultured pulmonary epithelium and in the lungs of infected mice. Inhibition of the 12-LOX pathway prevented pathogen-induced PMN transepithelial migration in vitro and dramatically reduced lung inflammation upon high-dose pulmonary challenge with S. pneumoniae in vivo, thus implicating HXA3 in pneumococcus-induced pulmonary inflammation. PMN basolateral-to-apical transmigration in vitro significantly increased apical-to-basolateral transepithelial migration of bacteria. Mice suppressed in the expression of 12-LOX exhibited little or no bacteremia and survived an otherwise lethal pulmonary challenge. Our data suggest that pneumococcal pulmonary inflammation is required for high-level bacteremia and systemic infection, partly by disrupting lung epithelium through 12-LOX–dependent HXA3 production and subsequent PMN transepithelial migration.
Influenza A Exacerbates Staphylococcus aureus Pneumonia by Attenuating IL-1β Production in Mice
Authors: Robinson Keven M. , Choi Sun Mi , McHugh Kevin J. , Mandalapu Sivanarayana , Enelow Richard I. , Kolls Jay K. , Alcorn John F.
Published: October 2013

Pneumonia is a leading cause of death worldwide. Staphylococcal aureus can be a cause of severe pneumonia alone or a common pathogen in secondary pneumonia following influenza. Recently, we reported that preceding influenza attenuated the Type 17 pathway, increasing the lung’s susceptibility to secondary infection. IL-1β is known to regulate host defense, including playing a role in Th17 polarization. We examined whether IL-1β signaling is required for S. aureus host defense and whether influenza infection impacted S. aureus–induced IL-1β production and subsequent Type 17 pathway activation. Mice were challenged with S. aureus (USA 300), with or without preceding Influenza A/PR/8/34 H1N1 infection. IL-1R1−/− mice had significantly higher S. aureus burden, increased mortality, and decreased Type 17 pathway activation following S. aureus challenge. Coinfected mice had significantly decreased IL-1β production versus S. aureus infection alone at early time points following bacterial challenge. Preceding influenza did not attenuate S. aureus–induced inflammasome activation, but there was early suppression of NF-κB activation, suggesting an inhibition of NF-κB–dependent transcription of pro–IL-1β. Furthermore, overexpression of IL-1β in influenza and S. aureus–coinfected mice rescued the induction of IL-17 and IL-22 by S. aureus and improved bacterial clearance. Finally, exogenous IL-1β did not significantly rescue S. aureus host defense during coinfection in IL-17RA−/− mice or in mice in which IL-17 and IL-22 activity were blocked. These data reveal a novel mechanism by which Influenza A inhibits S. aureus–induced IL-1β production, resulting in attenuation of Type 17 immunity and increased susceptibility to bacterial infection.
Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation
Authors: Heid Michelle E. , Keyel Peter A. , Kamga Christelle , Shiva Sruti , Watkins Simon C. , Salter Russell D.
Published: October 2013

The nucleotide-binding oligomerization domain–like receptor family, pyrin domain–containing 3 (NLRP3) inflammasome drives many inflammatory processes and mediates IL-1 family cytokine release. Inflammasome activators typically damage cells and may release lysosomal and mitochondrial products into the cytosol. Macrophages triggered by the NLRP3 inflammasome activator nigericin show reduced mitochondrial function and decreased cellular ATP. Release of mitochondrial reactive oxygen species (ROS) leads to subsequent lysosomal membrane permeabilization (LMP). NLRP3-deficient macrophages show comparable reduced mitochondrial function and ATP loss, but maintain lysosomal acidity, demonstrating that LMP is NLRP3 dependent. A subset of wild-type macrophages undergo subsequent mitochondrial membrane permeabilization and die. Both LMP and mitochondrial membrane permeabilization are inhibited by potassium, scavenging mitochondrial ROS, or NLRP3 deficiency, but are unaffected by cathepsin B or caspase-1 inhibitors. In contrast, IL-1β secretion is ablated by potassium, scavenging mitochondrial ROS, and both cathepsin B and caspase-1 inhibition. These results demonstrate interplay between lysosomes and mitochondria that sustain NLRP3 activation and distinguish cell death from IL-1β release.
Phenotypic Polarization of Activated Astrocytes: The Critical Role of Lipocalin-2 in the Classical Inflammatory Activation of Astrocytes
Authors: Jang Eunha , Kim Jong-Heon , Lee Shinrye , Kim Jae-Hong , Seo Jung-Wan , Jin Myungwon , Lee Maan-Gee , Jang Il-Sung , Lee Won-Ha , Suk Kyoungho
Published: October 2013

Astrocytes provide structural and functional support for neurons, as well as display neurotoxic or neuroprotective phenotypes depending upon the presence of an immune or inflammatory microenvironment. This study was undertaken to characterize multiple phenotypes of activated astrocytes and to investigate the regulatory mechanisms involved. We report that activated astrocytes in culture exhibit two functional phenotypes with respect to pro- or anti-inflammatory gene expression, glial fibrillary acidic protein expression, and neurotoxic or neuroprotective activities. The two distinct functional phenotypes of astrocytes were also demonstrated in a mouse neuroinflammation model, which showed pro- or anti-inflammatory gene expression in astrocytes following challenge with classical or alternative activation stimuli; similar results were obtained in the absence of microglia. Subsequent studies involving recombinant lipocalin-2 (LCN2) protein treatment or Lcn2-deficient mice indicated that the pro- or anti-inflammatory functionally polarized phenotypes of astrocytes and their intracellular signaling pathway were critically regulated by LCN2 under in vitro and in vivo conditions. Astrocyte-derived LCN2 promoted classical proinflammatory activation of astrocytes but inhibited IL-4–STAT6 signaling, a canonical pathway involved in alternative anti-inflammatory activation. Our results suggest that the secreted protein LCN2 is an autocrine modulator of the functional polarization of astrocytes in the presence of immune or inflammatory stimuli and that LCN2 could be targeted therapeutically to dampen proinflammatory astrocytic activation and related pathologies in the CNS.
Cutting Edge: CD1a Tetramers and Dextramers Identify Human Lipopeptide–Specific T Cells Ex Vivo
Authors: Kasmar Anne G. , Van Rhijn Ildiko , Magalhaes Kelly G. , Young David C. , Cheng Tan-Yun , Turner Marie T. , Schiefner Andre , Kalathur Ravi C. , Wilson Ian A. , Bhati Mugdha , Gras Stephanie , Birkinshaw Richard W. , Tan Li L. , Rossjohn Jamie , Shires John , Jakobsen Søren , Altman John D. , Moody D. Branch
Published: October 2013

Human CD1a mediates foreign Ag recognition by a T cell clone, but the nature of possible TCR interactions with CD1a/lipid are unknown. After incubating CD1a with a mycobacterial lipopeptide Ag, dideoxymycobactin (DDM), we identified and measured binding to a recombinant TCR (TRAV3/ TRBV3-1, KD of ≈100 μM). Detection of ternary CD1a/lipid/TCR interactions enabled development of CD1a tetramers and CD1a multimers with carbohydrate backbones (dextramers), which specifically stained T cells using a mechanism that was dependent on the precise stereochemistry of the peptide backbone and was blocked with a soluble TCR. Furthermore, sorting of human T cells from unrelated tuberculosis patients for bright DDM-dextramer staining allowed recovery of T cells that were activated by CD1a and DDM. These studies demonstrate that the mechanism of T cell activation by lipopeptides occurs via ternary interactions of CD1a/Ag/TCR. Furthermore, these studies demonstrate the existence of lipopeptide-specific T cells in humans ex vivo.
Coadministration of Polyinosinic:Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity
Authors: Quinn Kylie M. , Yamamoto Ayako , Costa Andreia , Darrah Patricia A. , Lindsay Ross W. B. , Hegde Sonia T. , Johnson Teresa R. , Flynn Barbara J. , Loré Karin , Seder Robert A.
Published: October 2013

Currently approved adjuvants induce protective Ab responses but are more limited for generating cellular immunity. In this study, we assessed the effect of combining two adjuvants with distinct mechanisms of action on their ability to prime T cells: the TLR3 ligand, polyinosinic:polycytidylic acid (poly I:C), and immunostimulatory complexes (ISCOMs). Each adjuvant was administered alone or together with HIV Gag protein (Gag), and the magnitude, quality, and phenotype of Gag-specific T cell responses were assessed. For CD8 T cells, all adjuvants induced a comparable response magnitude, but combining poly I:C with ISCOMs induced a high frequency of CD127+, IL-2–producing cells with decreased expression of Tbet compared with either adjuvant alone. For CD4 T cells, combining poly I:C and ISCOMs increased the frequency of multifunctional cells, producing IFN-γ, IL-2, and TNF, and the total magnitude of the response compared with either adjuvant alone. CD8 or CD4 T cell responses induced by both adjuvants mediated protection against Gag-expressing Listeria monocytogenes or vaccinia viral infections. Poly I:C and ISCOMs can alter Ag uptake and/or processing, and we therefore used fluorescently labeled HIV Gag and DQ-OVA to assess these mechanisms, respectively, in multiple dendritic cell subsets. Poly I:C promoted uptake and retention of Ag, whereas ISCOMs enhanced Ag degradation. Combining poly I:C and ISCOMs caused substantial death of dendritic cells but persistence of degraded Ag. These data illustrate how combining adjuvants, such as poly I:C and ISCOMs, that modulate Ag processing and have potent innate activity, can enhance the magnitude, quality, and phenotype of T cell immunity.
A hermeneutical reflection on the resurrection of Jesus Christ in question and answer 45 of the Heidelberg Catechism
Authors: Labuschagne Kobus
Published: October 2013

This article is an attempt to elaborate hermeneutically on the different historical contexts, related the one to the other and to the centre point of the resurrection of Jesus Christ, in question and answer 45 of the Heidelberg Catechism. The aim is not only to find the true meaning that the Heidelberg Catechism intends to convey in the mentioned question and answer, but also to explain the underlying hermeneutical thinking as well as to bring to the surface and explain alternative assumptions that ordinary church-going Christians experience as the unusual outcome of an unknown and different kind of approach. Different hermeneutical processes lead to different outcomes of understanding − sometimes worlds apart. Vanuit die sentrale punt van die opstanding van Jesus Christus in vraag en antwoord 45 van die Heidelbergse Kategismus, wil hierdie artikel in ’n hermeneutiese besinning oor die verskillende verbandhoudende historiese kontekste uitbrei. Die doel is nie slegs om die ware betekenis te vind van wat die Heidelbergse Kategismus in genoemde vraag en antwoord poog om weer te gee nie, maar ook om die onderliggende hermeneutiese denke te verduidelik en alternatiewe aannames, wat gewone Christen-kerkgangers as ’n vreemde en verskillende benaderings ervaar, na die oppervlakte te bring en te verduidelik. Verskillende hermeneutiese prosesse lei tot verskillende uitkomste van verstaan – soms wêrelde van mekaar verwyderd.
Prediction of Protein Essentiality by the Support Vector Machine with Statistical Tests
Authors: Hor Chiou-Yi , Yang Chang-Biau , Yang Zih-Jie , Tseng Chiou-Ting
Published: October 2013

Essential proteins include the minimum required set of proteins to support cell life. Identifying essential proteins is important for understanding the cellular processes of an organism. However, identifying essential proteins experimentally is extremely time-consuming and labor-intensive. Alternative methods must be developed to examine essential proteins. There were two goals in this study: identifying the important features and building learning machines for discriminating essential proteins. Data for Saccharomyces cerevisiae and Escherichia coli were used. We first collected information from a variety of sources. We next proposed a modified backward feature selection method and build support vector machines (SVM) predictors based on the selected features. To evaluate the performance, we conducted cross-validations for the originally imbalanced data set and the down-sampling balanced data set. The statistical tests were applied on the performance associated with obtained feature subsets to confirm their significance. In the first data set, our best values of F-measure and Matthews correlation coefficient (MCC) were 0.549 and 0.495 in the unbalanced experiments. For the balanced experiment, the best values of F-measure and MCC were 0.770 and 0.545, respectively. In the second data set, our best values of F-measure and MCC were 0.421 and 0.407 in the imbalanced experiments. For the balanced experiment, the best values of F-measure and MCC were 0.718 and 0.448, respectively. The experimental results show that our selected features are compact and the performance improved. Prediction can also be conducted by users at the following internet address: http://bio2.cse.nsysu.edu.tw/esspredict.aspx .
Understanding the Impact of Residents' Interpersonal Relationships During Emergency Department Referrals and Consultations
Authors: Chan Teresa , Sabir Kameron , Sanhan Sarila , Sherbino Jonathan
Published: October 2013

Background

Communicating with colleagues is a key physician competency. Yet few studies have sought to uncover the complex nature of relationships between referring and consulting physicians, which may be affected by the inherent relationships between the participants.

Objective

Our study examines themes identified from discussions about communications and the role of relationships during the referral-consultation process.

Methods

From March to September 2010, 30 residents (10 emergency medicine, 10 general surgery, 10 internal medicine) were interviewed using a semistructured focus group protocol. Two investigators independently reviewed the transcripts using inductive methods and grounded theory to generate themes (using codes for ease of analysis) until saturation was reached. Disagreements were resolved by consensus, yielding an inventory of themes and subthemes. Measures for ensuring trustworthiness of the analysis included generating an audit trail and external auditing of the material by investigators not involved with the initial analysis.

Results

Two main relationship-related themes affected the referral-consultation process: familiarity and trust. Various subthemes were further delineated and studied in the context of pertinent literature.

Conclusions

Relationships between physicians have a powerful influence on the emergency department referral-consultation dynamic. The emergency department referral-consultation may be significantly altered by the familiarity and perceived trustworthiness of the referring and consulting physicians. Our proposed framework may further inform and improve instructional methods for teaching interpersonal communication. Most importantly, it may help junior learners understand inherent difficulties they may encounter during the referral process between emergency and consulting physicians.
Comparison of 3 Dilation and Evacuation Technical Skills Models
Authors: Baldwin Maureen K. , Chor Julie , Chen Beatrice A. , Edelman Alison B. , Russo Jennefer
Published: October 2013

Background

Simulation training may improve patient safety, decrease trainer and trainee anxiety, and reduce the number of cases needed for competency. Complications associated with dilation and evacuation (D&E) have been directly related to provider skill level, yet no low-fidelity model has been formally described or evaluated in the literature for second-trimester D&E training.

Objective

We report physicians' assessments of the realism of 3 D&E models to establish a composite training model.

Methods

We surveyed experienced providers at 2 national conferences to evaluate 3 D&E models and rate each model's components on a Likert scale.

Results

Fifty-five obstetrics-gynecology and family medicine physicians completed the survey. Most respondents rated 4 components of 1 model as somewhat realistic or very realistic. The components rated highest were the fetal parts (82% [45 of 55]) and placenta (60% [30 of 50]). This model was rated as more likely to be used in training by 80% (43 of 54) of participants than the 2 other models, as rated by 28% (15 of 54) and 9% (5 of 54) of participants.

Conclusions

A model made from a plastic bottle containing a stuffed fabric form with detachable parts has tactile similarity to a D&E procedure and should be further developed for testing and training.
Use of Public Health Promotion Items to Improve Health in Saudi Arabia
Authors: Al Aboud Khalid , Jameel Waleed , Al Asmari Zaher , Al Osaimy Hamdan , Al Sobiani Awateef , Salam Samiah Abdul , Al Zahrani Yaseer
Published: October 2013

None
A Preliminary Study: Heart Rate Variability Biofeedback for Treatment of Postconcussion Syndrome
Authors: Lagos Leah , Thompson James , Vaschillo Evgeny
Published: October 2013

Heart rate variability (HRV) biofeedback (BFB) can be used to reduce activation of the sympathetic nervous system (SNS) and increase activation of the parasympathetic nervous system (PNS). A growing body of research suggests that increased arousal of the SNS contributes to the sustained state of postconcussion syndrome (PCS). It has also been postulated that underactivation of the PNS may also play a role in the postinjury state of autonomic dystonia, wherein the autonomic nervous system is in a state of imbalance and does not return to normal. In addition to autonomic imbalance, patients who are generally advised not to engage in physical exertion until asymptomatic from concussion, are known to experience secondary symptoms of fatigue and reactive depression. Recent research has established that such symptoms can delay the recovery from concussion indefinitely. By addressing both autonomic dysfunction and the secondary symptoms of depression and anxiety, HRV BFB may be an effective treatment for PCS by strengthening self-regulatory control mechanisms in the body and improving autonomic balance. Recent studies have suggested that HRV BFB has a positive impact in reducing stress and anxiety among athletes, and concussed athletes with higher perceived control over their symptoms have been shown to have faster recoveries post-injury. The primary purpose of the following case study was, therefore, to assess the feasibility of implementing HRV BFB with a concussed athlete suffering from postconcussion syndrome (PCS). The second objective was to prospectively examine the impact of ten weeks of HRV biofeedback on refractory postconcussion symptoms. During this pilot case study, the athlete attended 10 weekly sessions of HRV BFB, according to the protocol set forth by Lehrer, Vaschillo, and Vaschillo (2000). After 10 weeks of HRV biofeedback, the athlete exhibited clinically significant improvements in total mood disturbance, postconcussion symptoms, and headache severity. The results suggest that HRV BFB may be a useful adjunctive treatment for PCS, associated with increases in HRV and enhanced cardiovagal activity. Given these findings, a randomized controlled trial is warranted.
Exploring the impact of using tablet devices in enhancing students listening and speaking skills in tertiary education
Authors: Fayed Ismail , Yacoub Amer , Hussein Ali
Published: October 2013

With the massive increase in using mobile devices among individuals of all social backgrounds, the question of how these mobile devices may enhance learning arise. Smart smartphones and the most recent tablet computers have all sustained the vision and potentials of using mobile devices in education and learning. The unprecedented popularity of these devices among teenage learners both in high schools and university level encourages all researchers and educators to explore their influence on learning among individuals and groups. In this research project, students will explore the potentials of using mobile devices and new tablet technologies to sustain students' acquisition of listening and speaking skills in English as a second language (ESL). They will highlight the key features in these modern devices that support these language skills. This investigation process aims to identify possible educational mobile features such as mobile applications developed by other users, mobile collaboration applications over wireless connection, language games, synchronous and asynchronous technologies for optimum use of these devices particularly by tertiary level students in a positive and rather educational manner.
Supporting Practitioners in Implementing Mobile Learning and Overcoming Ethical Concerns: A Scenario-Based Approach
Authors: Andrews Trish , Dyson Laurel Evelyn , Wishart Jocelyn
Published: October 2013

Ethical concerns about mobile learning have been raised across all sectors of the educational system, sometimes resulting
in the banning of mobile phones in schools and retarding the adoption of mobile learning as rapidly as might have
initially been envisaged. A way of dealing with this problem is to empower mobile learning practitioners and researchers
to deal effectively with ethical dilemmas through the development of their ethical reasoning. A commonly accepted
approach to ethical development is by means of scenarios, to which ethical principles are applied in order to produce
solutions. In this paper four scenarios are presented which were developed at two mobile learning and ethics workshops
conducted in 2012. An ethics framework for the analysis of the scenarios is described and finally a strategy is outlined for
conducting professional development of teachers and academics as well as training for student teachers. The authors
propose that ethical scenarios provide not only a means of developing the competence of teachers and academics in
dealing with ethical issues in their mobile learning practice and research, but may well lead to the greater adoption of
mobile learning as fears of ethical issues diminish once a way to providing solutions is demonstrated. Finally, scenarios
are seen as a tool to foster conversations with educational managers and administrators in order to promote policy
development and practical responses to ethical issues in mobile learning.
About the Contextualization of Learning Objects in Mobile Learning Settings
Authors: Sotsenko Alisa , Jansen Marc , Milrad Marcelo
Published: October 2013

In recent years, many efforts have been undertaken in order to design and deploy learning activities that make use of modern mobile devices, like smartphones and tablet PC's. Hence, new possibilities for supporting these so-called mobile learning scenarios have risen. One of the major benefits of these kinds of learning scenarios is the possibility of a learner to have access to learning content independent of time and place and therefore, enabling learners to learn in very different situations. In order to support learning across different settings, this paper discusses an approach that allows identifying a best fitting format of a Learning Object (LO) with respect to the current situation of the learner. This approach allows to delivering learning content in a format that may suit the current context of the learner and therefore, it enables seamless learning.
AnswerPro: Designing to Motivate Interaction
Authors: AlSugair Balsam , Hopkins Gail , FitzGerald Elizabeth , Brailsford Tim
Published: October 2013

This paper describes the design and initial testing of AnswerPro, a mobile academic peer support system for UK KeyStage 3 and 4 pupils (11-16 year olds). AnswerPro is a web application that enables pupils to seek support from theirknowledgeable peers on various subjects. This paper correlates the findings from a previous requirements-gatheringexercise (Anonymous), and from research into academic motivation, to propose design elements embedded withinAnswerPro. A pilot study was conducted with 7 school pupils over 3 weeks. Participants then engaged in a focus groupwhich discussed their experience using AnswerPro and the motivational elements embedded within it. Findings fromtheir use of AnswerPro, and from the subsequent discussion, highlighted some problems with the embedded motivationalfeatures. As a result, suggestions for potential solutions and their merits are proposed for the next version of AnswerPro.
Ubiquitous Computing in Education: A SWOT Analysis by Students and Teachers
Authors: Asiimwe Edgar Napoleon , Khan Sana Zubair
Published: October 2013

Learning from anywhere anytime is a contemporary phenomenon in the field of education that is thought to be flexible, time and cost saving. The phenomenon is evident in the way computer technology mediates knowledge processes among learners. Computer technology is however, in some instances, faulted. There are studies that highlight drawbacks of computer technology use in learning. In this study we aimed at conducting a SWOT analysis on ubiquitous computing and computer-mediated social interaction and their affect on education. Students and teachers were interviewed on the mentioned concepts using focus group interviews. Our contribution in this study is, identifying what teachers and students perceive to be the strength, weaknesses, opportunities and threats of ubiquitous computing and computer-mediated social interaction in education. We also relate the findings with literature and present a common understanding on the SWOT of these concepts.

Results show positive perceptions. Respondents revealed that ubiquitous computing and computer-mediated social interaction are important in their education due to advantages such as flexibility, efficiency in terms of cost and time, ability to acquire computer skills. Nevertheless disadvantages where also mentioned for example health effects, privacy and security issues, noise in the learning environment, to mention but a few. This paper gives suggestions on how to overcome threats mentioned.
Using mobile technologies to promote learning and youth employment: a partnership approach
Authors: Ouerdiane Chamseddine
Published: October 2013

Information and communications technologies (ICTs), including mobile technologies, are having a dramatic impact upon societies in the Arab region. With the rapid upsurge in use of mobile technologies throughout the region, patterns of usage have shifted from making phone calls and surfing the internet to using social media tools for societal change. The Najjahni mobile platform in Tunisia represents a multi-level partnership to develop mobile education applications that has now reached over half a million young Tunisians. This paper provides an overview of the success of Najjahni, and the critical partnerships that have made such a project possible.
iPads for Innovative Knowledge Creation
Authors: Tamim Rana , Colburn Linda
Published: October 2013

Academicians, researchers, and practitioners agree that computer technology has an important role to play in the classroom, with the main ingredient for successful technology integration being pedagogy. The more recent trend receiving attention is mobile learning, particularly with the hype that the iPad is getting and its strong push to access educational systems as the 21st century tool for learning. The current poster will report preliminary results assessing the success of two project-based interdisciplinary collaborative activities that were implemented with 41 undergraduate education students at Zayed University in the United Arab Emirates. The design made use of various theoretical frameworks including constructivist learning theories, student-centered principles (APA, 1997; Laurillard, 2002; McCombs & Vakili, 2005), motivational theories (Greeno, Collins, & Resnick, 1996; Hickey & Zuiker, 2005), project-based learning (Blumenfeld et al., 1991), and cooperative and collaborative learning theories (Bruffee, 1993; Johnson & Johnson, 2008). The project was employed in two courses, namely Early Childhood Mathematics and Science and Literature for Children and Adolescents. In addition to course specific assignments, students completed the following two collaborative iPad-based assignments across both courses:

- Arabic Scientist/Mathematician Biography: students had to make use of the basic principals of writing biographies to design and develop a media product to teach young children about an Arab scientist/mathematician. For this assignment, the students were given full freedom to decide on what form of media product they want to present their biography with.

- E-book fairy/folk tale: students had to create e-book for a fairy/folk tale for young children that teaches or addresses mathematical concepts such as numeracy, shapes, patterns, and measurement.

The poster presentation will offer preliminary findings based on the data collected from interviews conducted with the students after the completion of the courses. Interviews probed students� perceptions about lessons learned, successes, challenges, and suggestions for future iterations of the courses. Moreover, a number of the projects will be actually showcased during the poster presentation by some of the students. In their presentation, students will discuss their own experience with the iPads, the applications they used, the challenges they faced and how they overcame them.
Paracetamol Interference in Uric Acid Levels in Uremic Patients Revealed by Monitoring Spent Dialysate
Authors: Tanner Risto , Arund Jürgen , Fridolin Ivo , Luman Merike
Published: October 2013

The aim of this study was to assess removal dynamics of paracetamol (PAR), as an extraordinary chromophore in spent dialysate, upon the optical monitoring of dialysis of end-stage renal disease patients with inflammation complications. Seven dialysis sessions of different patients were followed to whom PAR was used as a pain reliever or antipyretic. Spent dialysate was sampled hourly and analyzed using HPLC with MS/MS and UV detection. Quantitative calculations were made on the basis of the peak areas on the chromatograms at 280 nm for uric acid (UA) and 254 nm for PAR and its metabolites (PAR-M). Peaks of UA, PAR, PAR-glucuronide, and PAR-sulphate were identified on the basis of specific mass spectra. Removal of PAR was found to be proportional to that of uric acid if intake of the drug by patient occurred half a day before dialysis. But disturbances of the UV-absorbance curves at 280 nm were observed related to rise of UA concentration in spent dialysate when PAR was taken by patients in the course of dialysis. The mechanism of such relation remains unknown. It was concluded that possible benefits and risks of treatment of uremic patients with paracetamol-containing drugs may need to be reassessed.
On certain classes of meromorphically p-valent starlike and p-valent quasi-convex functions
Authors: Sokol Janusz , Dziok Jacek , Aouf M. K.
Published: October 2013

By making use of a familiar analogue of the generalized hypergeometric function, we introduce and investigate some inclusion properties of certain class of meromorphically p-valent starlike functions of order $\lambda \ $ and certain class of meromorphically p-valent quasi-convex functions of order $\lambda $.
On a subclass of p-harmonic mappings
Authors: Porwal Saurabh , Dixit Kaushal Kishore
Published: October 2013

The purpose of the present paper is to introduce two new classes $HS_p(\alpha)$ and $HC_p(\alpha)$ of $p$-harmonic mappings together with their corresponding subclasses $HS^0_p(\alpha)$ and $HC^0_p(\alpha)$. We prove that the mappings in $HS_p(\alpha)$ and $HC_p(\alpha)$ are univalent and sense-preserving in $U$ and obtain extreme points of $HS^0_p(\alpha)$ and $HC^0_p(\alpha)$, $HS_p(\alpha)\cap T_p$ and $HC_p(\alpha)\cap T_p$ are determined, where $T_p$ denotes the set of $p$-harmonic mapping with non negative coefficients. Finally, we establish the existence of the neighborhoods of mappings in $HC_p(\alpha)$. Relevant connections of the results presented here with various known results are briefly indicated.
Some relations on the growth rates of composite entire functions using their (p,q) th order
Authors: Datta Sanjib Kumar , Biswas Tanmay , Biswas Manab
Published: October 2013

In this paper we discuss the growth rates of the maximum term of composition of entire functions with their corresponding left and right factors.
Significações da reprovação escolar por alunos adolescentes de escola pública
Authors: Santos Jéssica Augusta , Sant'Ana Ruth Bernardes
Published: October 2013

http://dx.doi.org/10.5902/198464445113Este artigo tem como objetivo apresentar uma experiência de pesquisa que buscou compreender as significações da reprovação escolar e os elementos a ela relacionados por alunos das últimas séries do Ensino Fundamental em escolas públicas do município de São João del-Rei, Minas Gerais. Os adolescentes pesquisados frequentam o ensino regular e o Programa Acelerar para Vencer (PAV), implementado pelo governo mineiro em 2008. Tomamos como embasamento as contribuições das perspectivas teórico-metodológicas do interacionismo, sobretudo na sua vertente etnometodológica. O estudo revelou que os sentidos conferidos à reprovação oscilam entre a rejeição e a crença no seu poder disciplinador. Notamos na fala dos alunos que a reprovação só é vista como uma situação de fracasso para aqueles que vêem a escola como o único caminho para o sucesso profissional.Abstract: This paper aims to present a survey experience which sought to understand the meanings of school reprobation and the elements related to it by students on the last grades of elementary public schools in São João del-Rei, Minas Gerais. Presently, the investigated teenagers attend the regular teaching program and Programa Acelerar para Vencer (PAV), implemented by the state government in 2008. We take as basement some contributions from theoretical and methodological perspectives of interactionism, especially its ethnomethodological aspect. The study showed that the meanings given to the school reprobation range from rejection and belief in its disciplinary power. We notice in the students’ speeches that reprobation is only seen as a failure by those students who see school as the only way to professional success.
Saberes necessários ao bom professor: dizeres de licenciandos e estudantes da Educação Básica
Authors: Kollas Franciele , Marques Roberta , Megier Ana Paula Antunes , Frison Marli Dallagnol
Published: October 2013

http://dx.doi.org/10.5902/198464445700 Este estudo traz resultados da reflexão comparativa entre fatores que licenciandos e estudantes da Educação Básica consideram essenciais para o bom professor. Entendemos que processos de ensino e de aprendizagem exigem para além dos conhecimentos específicos de professor. Tais processos impõem o estabelecimento de interações de ordem não cognitivas podendo ser afetivas, motivadoras ou dialógicas. Para tanto, discutimos questões relacionadas a habilidades e saberes necessários ao desenvolvimento de um ensino que promova condições para uma aprendizagem real. A metodologia constituiu-se de questionários aplicados a licenciandos dos cursos de Química, Física e Biologia e a estudantes da Educação Básica. Resultados indicam que, além dos saberes daqueles que ensinam, a afetividade, o diálogo e a motivação são indispensáveis para o desenvolvimento da prática docente e para a constituição do professor.
O papel do tutor virtual na educação a distância
Authors: Grossi Márcia Gorett Ribeiro , Costa José Wilson , Moreira Mércia Maria
Published: October 2013

http://dx.doi.org/10.5902/198464446656 A Educação a Distância (EaD)  vem ganhando destaque na sociedade atual, seja pela emergência das tecnologias da informação, como também pela necessidade cada vez maior de conhecimento e formação. Entendendo que as tecnologias usadas nos cursos a distância, por si só, não são suficientes para garantir o sucesso desta modalidade de ensino, destaca-se a figura do tutor virtual, que atua juntamente com o professor no sentido de promover aprendizagens significativas, motivar o aluno a participar mais ativamente das atividades propostas e facilitando o processo de interatividade. Nesta perspectiva o objetivo desta pesquisa foi verificar as funções do tutor virtual como coadjuvante no processo de ensino e aprendizagem, bem como os limites do seu exercício profissional. Para alcançar esse objetivo foi realizado um estudo de caso em duas instituições de ensino que oferecem EaD, uma publica e outra particular. Através da pesquisa foi possível compreender algumas características peculiares a esse trabalho da tutoria virtual, bem como fazer algumas inferências, sobretudo, sobre a necessidade de um olhar mais atento para as atividades desses profissionais como para a sua regulamentação.
Expectativas dos alunos de diferentes faixas etárias do Técnico em Agropecuária quanto à Educação Profissional
Authors: Both Vanderlei , Pavanello Elizandra Pivotto , Rocha Karla Marques da
Published: October 2013

http://dx.doi.org/10.5902/198464447081 Devido às diferentes faixas etárias dos alunos do Curso Técnico em Agropecuária do Colégio Politécnico da UFSM, o estudo objetivou buscar informações, de modo a auxiliar os professores e a escola a estabelecerem estratégias de ensino, em função das suas diversas expectativas e trajetórias. Para isso, foi aplicado um questionários com 13 questões mistas para os 55 alunos ingressantes. Para avaliação dos dados, o grupo foi dividido em duas categorias, que revelaram a existência de diferenças nas trajetórias escolares, bem como nas expectativas quanto ao curso, sendo que os alunos mais jovens apresentam uma clara tendência de estarem realizando o curso apenas por não terem ingressado em um curso superior. Já os alunos mais velhos, buscam no curso também outras alternativas, como o conhecimento técnico para atuarem nessa área ou como complemento à graduação que estão cursando. Assim, os professores e a escola precisam reforçar aos alunos, especialmente aos mais jovens, as possibilidades do curso, a fim de estimular a concluírem o mesmo, formando profissionais que possam trazer retorno à comunidade em que irão atuar.
A relação trabalho-educação no organização do trabalho pedagógico da escola capitalista
Authors: Frizzo Giovanni Felipe Ernst , Ferreira Liliana Soares , Ribas João Francisco Magno
Published: October 2013

http://dx.doi.org/10.5902/198464448987 Analisa-se a relação trabalho-educação no projeto de formação humana na escola capitalista, tomando como fenômeno de estudo a organização do trabalho pedagógico, isto é, as relações e processos que se estabelecem entre os sujeitos da escola (professores e estudantes) e o conhecimento apreendido por estes durante a vida escolar. Para tanto, organizou-se o texto em duas partes: a primeira trata da relação trabalho-educação como fenômeno próprio do ser humano, cujas características históricas cindem a relação do ser com o trabalho e, em decorrência disso, com seus processos educativos; a segunda parte trata da organização do trabalho pedagógico na escola capitalista, na qual evidenciamos que as duas categorias principais que dotam de sentido a formação dos estudantes na escola são a empregabilidade e o disciplinamento para a esfera produtiva.   Palavras-chave: trabalho pedagógico, escola, capitalismo
A diversidade na escola e as nova demandas para o trabalho docente
Authors: Gonçalves Gustavo Bruno Bicalho
Published: October 2013

http://dx.doi.org/10.5902/198464448988 O artigo parte de um levantamento das políticas voltadas para a atenção à diversidade na educação, sua origem e o contexto de sua emergência. É analisado seu objetivo  manifesto de contribuir para a promoção da justiça social e da justiça escolar. Em seguinda busca-se analisar o papel desempenhado pelos professores em função destes novos objetivos que se apresentam para a escola. Considera-se que, da forma como encontram-se difundidos hoje os objetivos de atendimento à diversidade no contexto de uma escola meritocrática, os conflitos advindos deste paradoxo frequentemente recaem sobre os professores. Cabe a eles eles compatibilizar o peso dos diplomas como principal estratégia de distribuição de lugares na hierarquia social. Partindo-se de alguns dados da segunda fase da pesquisa “Trabalho docente na educação básica no Brasil” busca-se identificar os efeitos dessas políticas nas leituras que os próprios professores fazem desta contradição em seu trabalho.  Finalmente, o artigo busca propor uma atuação instituinte dos professores que poderia criar um espaço para que a diferença entre os alunos não implique em crescente desigualdade entre eles, sempre tendo em vistas também a criação de um ambiente de trabalho mais saudável para os professores.   Palavras-Chave: trabalho docente; diversidade, saúde e trabalho
Trabalho imaterial e trabalho docente
Authors: Hypolito Álvaro Moreira , Grishcke Paulo Eduardo
Published: October 2013

http://dx.doi.org/10.5902/198464448998 O artigo discute a tendência do trabalho da sociedade capitalista no contexto da reestruturação produtiva contemporânea, argumentando a favor da perspectiva que sustenta a tendência de aumento e consolidação da forma de trabalho imaterial como modo hegemônico na sociedade do conhecimento. Discorre sobre as formas do trabalho no setor de serviços e discute as diversas formas do trabalho imaterial na sociedade atual. Por fim discute o trabalho docente como uma forma de trabalho imaterial que está relacionada com aspectos subjetivos e emocionais da identidade docente. É um texto de discussão teórica sobre o trabalho docente no contexto atual do capitalismo.
Tensões e conflitos entre vida e trabalho no capitalismo contemporâneo
Authors: Roggero Rosemary
Published: October 2013

http://dx.doi.org/10.5902/198464449235 O artigo questiona a possibilidade de libertação da subjetividade, no campo de tensão entre vida e trabalho que constitui a qualificação profissional. Para tanto, analisa as aproximações entre formação e trabalho, em direção à consciência de si e à consciência social, no âmbito da cultura. Observa, ainda, o modo como o conceito de competência aponta para processos de formação voltados à mera adaptação à lógica capitalista, reduzindo a vida ao trabalho.
Atividade docente, currículo e os campos de influência na sala de aula
Authors: Pizzi Laura Cristina Vieira , Melo Wanessa Lopes de
Published: October 2013

http://dx.doi.org/10.5902/198464444937 O objetivo deste artigo é analisar a atividade docente, a partir da perspectiva da Clínica da Atividade de Yves Clot (2010), com foco no currículo escolar desenvolvido na sala de aula, considerando as condições de realização, as prescrições, os imprevistos e os atravessamentos presentes no cotidiano. Para nos aproximarmos da complexidade do currículo utilizamos a técnica da autoconfrontação simples, que utiliza a filmagem como principal meio de coleta de dados. A professora participante desta pesquisa atuava na 2ª série de uma escola de Ensino Fundamental da rede pública municipal de Maceió/AL, localizada na periferia. O caráter prescritivo das políticas curriculares não se mostrou determinante na atividade curricular dessa docente, frente a outros fatores subjetivos e outros conteúdos e sujeitos que reajustaram o currículo realizado, imprimindo novos desdobramentos e implicações.
A integração das práticas de pesquisa e de ensino e a formação do profissional reflexivo
Authors: Therrien Jacques , Therrien Silvia Maria Nóbrega
Published: October 2013

http://dx.doi.org/10.5902/198464449266 O estudo aborda areflexividade crítica como elemento mediador da integração entre as práticas depesquisa e de ensino na formação do profissional de educação. Apoiado noparâmetro da pesquisa como princípio educativo associado ao pressuposto que oenvolvimento em atividades de pesquisa favorece o desenvolvimento de racionalidadesque dão suporte a práticas reflexivas que conduzem a aprendizagens maissignificativas e autônomas no ensino, o ensaio se propõe: por um lado, aidentificar um esquema teórico ‘macro’ que possa dar suporte à análise de tiposde conhecimento, e, portanto, de racionalidades que movem a dinâmica da relaçãoteoria-prática na ação educativa;  poroutro lado, a encontrar esquemas teórico-práticos ‘micros’ de formação para a reflexividade relacionados à prática em contextos de aprendizagem. O estudo analisa propostas de autores de referência, assim como práticas educativas que dão suporte aos pressupostos enunciados.
Activation of Human Mesenchymal Stem Cells Impacts Their Therapeutic Abilities in Lung Injury by Increasing Interleukin (IL)-10 and IL-1RN Levels
Authors: Bustos Martha L. , Huleihel Luai , Meyer Ernest M. , Donnenberg Albert D. , Donnenberg Vera S. , Sciurba Joseph D. , Mroz Lyle , McVerry Bryan J. , Ellis Bryon M. , Kaminski Naftali , Rojas Mauricio
Published: October 2013

Acute respiratory distress syndrome (ARDS) is an important cause of morbidity and mortality, with no currently effective therapies. Several preclinical studies have shown that human mesenchymal stem cells (hMSCs) have therapeutic potential for patients with ARDS because of their immunomodulatory properties. The clinical use of hMSCs has some limitations, such as the extensive manipulation required to isolate the cells from bone marrow aspirates and the heterogeneity in their anti-inflammatory effect in animal models and clinical trials. The objective of this study was to improve the protective anti-inflammatory capacity of hMSCs by evaluating the consequences of preactivating hMSCs before use in a murine model of ARDS. We injected endotoxemic mice with minimally manipulated hMSCs isolated from the bone marrow of vertebral bodies with or without prior activation with serum from ARDS patients. Minimally manipulated hMSCs were more efficient at reducing lung inflammation compared with isolated and in vitro expanded hMSCs obtained from bone marrow aspirates. Where the most important effect was observed was with the activated hMSCs, independent of their source, which resulted in increased expression of interleukin (IL)-10 and IL-1 receptor antagonist (RN), which was associated with enhancement of their protective capacity by reduction of the lung injury score, development of pulmonary edema, and accumulation of bronchoalveolar lavage inflammatory cells and cytokines compared with nonactivated cells. This study demonstrates that a low manipulation during hMSC isolation and expansion increases, together with preactivation prior to the therapeutic use of hMSCs, would ensure an appropriate immunomodulatory phenotype of the hMSCs, reducing the heterogeneity in their anti-inflammatory effect.