bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and genetic correlations of scoliosis in Rett syndrome
Authors: Rodocanachi Roidi Marina Luisa , Cozzi Francesca , Isaias Ioannis Ugo , Grange Francesca , Ferrari Elena Paola , Ripamonti Enrico
Published: April 2022

Aim

To identify the clinical features correlating with the presence and severity of scoliosis in girls with Rett syndrome (RTT).

Method

Seventy-five girls with a clinical and genetically determined diagnosis of RTT participated in this cross-sectional study. Clinical scales administered included the Rett assessment rating scale, the modified Ashworth scale, the Rett syndrome motor evaluation scale, the PainAD, and the scale of evaluation of purposeful hand function. Multivariable analyses, such as ordinal logistic regression and ANCOVA, were used to assess the correlation between these scales and a clinical score of scoliosis.

Results

About 60% of patients had scoliosis, in general mild or moderate. The severity of scoliosis correlated with age and important neurological factors such as muscular hypertonus and hyperreflexia, standing, walking (level walking and on stairs), and postural transitions. No association was found with global disease severity, hand function, pain, or type of genetic mutation.

Interpretation

Scoliosis is a relevant problem in RTT. It should be carefully monitored along the life span, especially in conjunction with (loco-)motor impairment in these patients.
The effect of metamorphism on the aggregate properties of gabbroic rocks
Authors: Urueña Cindy , Möller Charlotte , Andersson Jenny , Lindqvist Jan-Erik , Göransson Mattias
Published: April 2022

Granitic rocks are durable materials sought after for the production of road and railroad aggregates. Granitic bedrock commonly, however, includes gabbroic components, which may enhance or decrease the aggregate performance. This study evaluates the variation in resistance to fragmentation (Los Angeles value, LA) and wear/abrasion (micro-Deval value, MDE) for the fraction 10/14 mm of gabbro in different metamorphic states. Samples were collected along a 150-km profile where metamorphic conditions grade from epidote–amphibolite to high-pressure granulite-facies, and the degree of metamorphic recrystallization varies with the amount of hydrous fluid. Rocks with no or incipient metamorphic recrystallization preserving their primary igneous fabric and interlocking texture meet the criteria for both asphalt base course and track ballast in railroad, with LA and MDE values below 25% and 14%, respectively. Mafic granulite and fine-grained amphibolite have LA values below 25% and can be used in unbound layers. Mafic granulites crystallize at high temperatures but commonly preserve a relict igneous texture due to limited hydration. Coarse-grained amphibolite and migmatitic amphibolite have the poorest performance. They recrystallized at hydrous conditions, leading to complete recrystallization, grain coarsening, and loss of interlocking igneous texture. This study shows that both temperature and infiltration of hydrous fluids significantly affect the technical properties. Even at high metamorphic temperatures, gabbroic rocks may yield aggregates of high technical performance. At hydrous conditions, however, recrystallization results in rock aggregates suitable for unbound layers only. The variation in metamorphic grade and hydration is easily assessed by the geologist in the field and by using standard petrographic microscopy.
Circular economy for durable products and materials: the recycling of plastic building products in Germany—status quo, potentials and recommendations
Authors: Bendix Phillip , Achenbach Hermann , Weißhaupt Petra , Eckert Daniela , Oehme Ines , Berg Holger
Published: April 2022

The construction sector is the second largest area for the application for plastics. Due to the long life times of construction products, the implementation of the circular economy faces its own challenges. To investigate this challenge, the study covers a market study for Germany, voluntary take-back and recycling schemes of construction products, as well as the use of plastic recyclates in construction products. In addition, plastic packaging of construction products is covered. Opportunities and barriers to the use of recycled plastics in construction products are derived from the intersection of available technologies, recyclate supply, and technical requirements for construction products. The report concludes with recommendations to various stakeholders on how to promote the use of recyclates in construction products and their packaging. Important points here are the introduction of a recyclate quota for films as construction product packaging and the description of recycling possibilities and recyclate content in the technical documentation of construction products.
Lenvatinib combined with nivolumab in advanced hepatocellular carcinoma-real-world experience
Authors: Wu Wen-Chi , Lin Tzu-Yuan , Chen Ming‑Huang , Hung Yi‑Ping , Liu Chien-An , Lee Rheun‑Chuan , Huang Yi‑Hsiang , Chao Yee , Chen San-Chi
Published: April 2022

Lenvatinib, a multi-tyrosine kinase inhibitor that inhibits vascular endothelial growth factor and fibroblast growth factor receptors pathway, activated the immune response in tumor microenvironment. However, the combination of lenvatinib and anti-PD-1 has been reported in early phase studies. Hence, this study aims to explore the efficacy and toxicity of lenvatinib combined with nivolumab in the real-world setting. Advanced HCC patients who underwent lenvatinib combined with nivolumab (L + N group) treatment at Taipei Veterans General Hospital (Taipei, Taiwan) were reviewed between January 2016 and December 2020. Treatment response and outcomes were collected and analyzed. A control group with lenvatinib (L group) was also included for comparison. Forty patients were included in L + N group and 47 in L group. The L + N group demonstrated a higher objective response rate than L group (45.0% vs. 23.4%, p = 0.03). The L + N group also achieved longer PFS (7.5 vs. 4.8 months, p = 0.05) and OS (22.9 vs. 10.3 months, p = 0.01) than L group. Patients with HBV infection and REFLECT criteria fit demonstrated a trend of better prognosis. The PFS for those with PR, SD and PD groups were 11.2, 6.4, and 2.2 months and OS were non-reached, 14.6 and 4.7 months, respectively. Portal vein thrombosis (HR 4.3, 95% C.I. 1.5–12.8) and AFP > 400 ng/mL (HR 3.3, 95% C.I. 1.1–9.3) were poor prognostic factors and nivolumab used remained a protective factor (HR 0.2, 95% C.I. 0.1–0.7). Dermatitis (35.0%), pruritis (27.5%), and hypothyroidism (27.5%) were the common toxicities. Few patients developed grade 3/4 toxicities, including dermatitis (15%), gastrointestinal bleeding (7.5%), hypertension (5.0%), pneumonitis (2.5%) and stomatitis (2.5%). This is the first real-world data reporting the promising efficacy and tolerable toxicities of lenvatinib combined with nivolumab in advanced HCC. Further randomized trials are prompted.
Heavy elements
Authors: Hansen Camilla Juul
Published: April 2022

How are the heavy elements formed? This has been a key open question in physics for decades. Recent direct detections of neutron star mergers and observations of evolved stars show signatures of chemical elements in the blue range of their spectra that bear witness of recent nuclear processes that led to heavy element production. The formation of heavy elements typically takes place through neutron-capture reactions creating radioactive isotopes, which following beta-decay turn into the stable isotopes we today can measure indirectly in the surfaces of cool, low-mass stars or meteoritic grains. The conditions (such as the neutron density or entropy) of these n-capture reactions remain to date poorly constrained, and only through a multidisciplinary effort can we, by combining and comparing observations, experiments, and theoretical predictions, improve on one of the top 10 most important open physics questions posed at the turn of the century. This emphasises the need for detailed observations of the near-UV to blue wavelength region. The shortage of spectrographs and hence spectra covering this range with high-resolution and high signal-to-noise has for decades played a limiting factor in our understanding of how heavy elements form in the nuclear reactions as well as how they behave in the stellar surfaces. With CUBES (Cassegrain U-Band Efficient Spectrograph) we can finally improve the observations, by covering the crucial blue range in more remote stars and also achieve a higher signal-to-noise ratio (SNR). This is much needed to detect and accurately deblend the absorption lines and in turn derive more accurate and precise abundances of the heavy elements.
Similar distribution of 15N labeled cattle slurry and mineral fertilizer in soil after one year
Authors: Frick Hanna , Oberson Astrid , Cormann Michael , Wettstein Hans-Rudolf , Frossard Emmanuel , Bünemann Else Katrin
Published: April 2022

Targeted use of animal manures as a nitrogen (N) fertilizer is challenging because of their poorly predictable N fertilizer value. An enhanced understanding of their N transformation processes in soil under field conditions is necessary to better synchronize N availability and crop N demand. 15N labeled cattle slurry, produced by feeding a heifer with 15N labeled ryegrass hay, was used in an on-farm trial on two neighboring fields, cropped with maize or grass-clover, in order to assess crop N uptake and N dynamics in the topsoil. Recovery of applied total N in plant biomass was higher for mineral fertilizer (Min) (45–48%) than for slurry (Slu) (17–22%) when applied at the same rate of mineral N. Also, N derived from fertilizer in plant biomass was higher for Min than for Slu, due to both greater NH3 emissions and greater initial immobilization of slurry N. Despite initial differences between the two in the relative distribution of residual fertilizer N in soil N pools, already in the following spring the majority (77–89%) of residual N from both fertilizers was found in the non-microbial organic N pool. Of the applied total N, 18–26% remained in the topsoil after the first winter for Min, compared to 32–52% for Slu. Thus, the proportion of fertilizer N not taken up by the first crop after application, enters the soil organic N pool and must be re-mineralized to become plant available.
Distinct Psychological Profiles Linking Childhood Adversity and Substance Misuse in High-Risk Young Adults
Authors: van Zyl Tara-Lynne , O’Neill Tara , Rushe Teresa
Published: April 2022

Adverse childhood experiences (ACEs) constitute a key determinant in the development of substance misuse. However, the understanding of how ACEs cultivate this risk lacks the specificity needed to inform effective prevention and intervention practices. This issue may be remedied by exploring the distinction between ACEs and their effects on development. The present study investigated whether distinct patterns of adversity are differentially associated with substance misuse along unique profiles of psychological variables, namely anxiety and punishment sensitivity – an internalizing profile – versus reward sensitivity and executive functioning – an externalizing profile. Using a cross-sectional retrospective design, 124 high-risk young adults completed assessments of childhood adversity and psychological functioning. We employed the ACE-IQ to capture extended ACEs such as community and collective violence, as our sample grew up in the post-conflict society of Northern Ireland. Exploratory Factor Analysis revealed three patterns of adversity co-occurrence – Childhood Maltreatment, Household Dysfunction and Community Adversity, all of which independently predicted different types of substance misuse. Childhood Maltreatment was significantly associated with heavy drug use probability; Household Dysfunction was associated with cannabis dependence probability; and Community Adversity was associated with both cannabis dependence and heavy drug use probability. Logistic regressions (all p < .05) showed that heavy drug use probability was predicted by Childhood Maltreatment and anxiety in one model, and by Community Adversity and reduced punishment sensitivity in another, suggesting that different types of ACEs were associated with partially distinct outcomes in this sample. These results support the proposal that different ACE subtypes confer distinct effects, which carries clinical implications for substance misuse prevention and intervention.
Thermal behavior and antibacterial studies of a carbonate Mg–Al-based layered double hydroxide (LDH) for in vivo uses
Authors: Cardinale Anna Maria , Vecchio Ciprioti Stefano , Fortunato Marco , Catauro Michelina
Published: April 2022

The goal of this work is to study the thermal behavior and the antibacterial properties of a MgAl-CO3 layered double hydroxide (LDH), which demonstrated high efficiency in removing chromium (VI) from contaminated industrial wastewater. The compound has been synthesized via co-precipitation route (direct method) followed by hydrothermal treatment, obtaining nanoscopic crystallites with a partially disordered (turbostratic) structure. After its synthesis, the compound was characterized by means of X-ray powder diffraction, field emission scanning electron microscope, inductively coupled plasma atomic emission spectroscopy and analysis and Fourier transform infrared spectroscopy. On the other hand, with the view to check the drug delivery and surgical tools usage of MgAl-CO3, antibacterial tests, performed according to the Kirby–Bauer method, revealed the inability the growth of the pathogenic bacterial strains. Thermogravimetry and differential thermal analysis revealed that evolution of water from the material occurs in two stages upon heating and a noticeable interaction takes place between water (in the vapor phase) and MgAl-CO3. Kinetic analysis of both steps provides almost constant values of activation energy, with the following average values in the range 0.1 < a < 0.9: E1 = (66 ± 9) kJ mol‒1; E2 = (106 ± 7) kJ mol‒1. Finally, prediction of reasonable reaction times extrapolated at 25 and 37 °C has been made from kinetic parameters of the first step, while almost unrealistic reaction time values were determined using the same procedure with kinetic parameters related to the second step.
Beneficial effects of antisymmetric nonlinear damping with application to energy harvesting and vibration isolation under general inputs
Authors: Zhu Yun-Peng , Lang Z. Q.
Published: April 2022

Beneficial effects of nonlinear damping on energy harvesting and vibration isolation under harmonic inputs have been investigated showing that the introduction of nonlinear damping can increase the harvested energy and reduce the vibration over both the resonant and higher frequency ranges. However, the scenario becomes more complicated when the loading inputs are of more general form such as multi-tone and random inputs, which can produce system responses that are induced by an interaction of system input components of different frequencies. In the present study, by introducing the concept of power transmissibility, the study of the beneficial effects of nonlinear damping is extended to the systems subject to general inputs including both multi-tone and random inputs. A rigorous analysis is conducted based on single degree of freedom systems subject to general inputs. The analysis reveals the conditions under which the antisymmetric nonlinear damping is beneficial for improving energy harvester performance and reducing of the power of system output in vibration isolation. Moreover, the beneficial effects are demonstrated by two case studies.
Amodal completion and relationalism
Authors: Nanay Bence
Published: April 2022

Amodal completion is usually characterized as the representation of those parts of the perceived object that we get no sensory stimulation from. In the case of the visual sense modality, for example, amodal completion is the representation of occluded parts of objects we see. I argue that relationalism about perception, the view that perceptual experience is constituted by the relation to the perceived object, cannot give a coherent account of amodal completion. The relationalist has two options: construe the perceptual relation as the relation to the entire perceived object or as the relation to the unoccluded parts of the perceived object. I argue that neither of these options are viable.
Evolution of salt tolerance in Arabidopsis thaliana on siliceous soils does not confer tolerance to saline calcareous soils
Authors: Pérez-Martín Laura , Busoms Silvia , Almira Maria Jose , Azagury Nicole , Terés Joana , Tolrà Roser , Poschenrieder Charlotte , Barceló Juan
Published: April 2022

Purpose

Alkaline salinity constrains crop yield. Previously, we observed local adaptation of Arabidopsis thaliana to saline-siliceous soils (pH ≤ 7) and to non-saline carbonate soils. However, no natural population of A. thaliana was localized on saline-alkaline soils. This suggests that salinity tolerance evolved on saline-siliceous soils may not confer tolerance to alkaline salinity. This hypothesis was explored by addressing physiological and molecular responses to alkaline salinity of A. thaliana that differ in tolerance to either non-alkaline salinity or carbonate.

Methods

A. thaliana native to saline-siliceous soils (high salinity, HS), non-saline carbonate soils (high alkalinity, HA), or soils with intermediate levels of these factors (medium saline-alkalinity, MSA) were cultivated in common gardens on saline-siliceous or saline-calcareous substrates. Hydroponics and irrigation experiments confirmed the phenotypes. The growth, mineral concentrations, proline content, osmotic potential, genetic variation distribution, and expression levels of selected genes involved in salinity and alkalinity tolerance were assessed.

Results

HS performed best on saline-siliceous soil and in hydroponics with salinity (pH 5.9). However, HS was more sensitive to saline-alkaline conditions than HA and MSA. The fitness under saline-alkaline conditions was ranked according to MSA > HA > HS. Under alkaline salinity, MSA best maintained ion homeostasis, osmotic balance, and higher expression levels of key genes involved in saline or alkaline tolerance (AHA1, root HKT1 and FRO2, and shoot NHX1 and IRT1).

Conclusion

In A. thaliana, salinity tolerance evolved on saline-siliceous soils does not provide tolerance to alkaline salinity. Plants native to intermediate conditions (MSA) have more plasticity to adapt to alkaline salinity than those locally adapted to these individual stress factors.
Food cue reactivity: Neurobiological and behavioral underpinnings
Authors: Kanoski Scott E. , Boutelle Kerri N.
Published: April 2022

The modern obesogenic environment contains an abundance of food cues (e.g., sight, smell of food) as well cues that are associated with food through learning and memory processes. Food cue exposure can lead to food seeking and excessive consumption in otherwise food-sated individuals, and a high level of food cue responsivity is a risk factor for overweight and obesity. Similar food cue responses are observed in experimental rodent models, and these models are therefore useful for mechanistically identifying the neural circuits mediating food cue responsivity. This review draws from both experimental rodent models and human data to characterize the behavioral and biological processes through which food-associated stimuli contribute to overeating and weight gain. Two rodent models are emphasized – cue-potentiated feeding and Pavlovian-instrumental transfer – that provide insight in the neural circuits and peptide systems underlying food cue responsivity. Data from humans are highlighted that reveal physiological, psychological, and neural mechanisms that connect food cue responsivity with overeating and weight gain. The collective literature identifies connections between heightened food cue responsivity and obesity in both rodents and humans, and identifies underlying brain regions (nucleus accumbens, amygdala, orbitofrontal cortex, hippocampus) and endocrine systems (ghrelin) that regulate food cue responsivity in both species. These species similarities are encouraging for the possibility of mechanistic rodent model research and further human research leading to novel treatments for excessive food cue responsivity in humans.
Anomalous Cosmic Rays and Heliospheric Energetic Particles
Authors: Giacalone J. , Fahr H. , Fichtner H. , Florinski V. , Heber B. , Hill M. E. , Kóta J. , Leske R. A. , Potgieter M. S. , Rankin J. S.
Published: April 2022

We present a review of Anomalous Cosmic Rays (ACRs), including the history of their discovery and recent insights into their acceleration and transport in the heliosphere. We focus on a few selected topics including a discussion of mechanisms of their acceleration, escape from the heliosphere, their effects on the dynamics of the heliosheath, transport in the inner heliosphere, and their solar cycle dependence. A discussion concerning their name is also presented towards the end of the review. We note that much is known about ACRs and perhaps the term Anomalous Cosmic Ray is not particularly descriptive to a non specialist. We suggest that the more-general term: “Heliospheric Energetic Particles”, which is more descriptive, for which ACRs and other energetic particle species of heliospheric origin are subsets, might be more appropriate.
Simple Remembering
Authors: Schwartz Arieh
Published: April 2022

Dretske has provided very influential arguments that there is a difference between our sensory awareness of objects and our awareness of facts about these objects—that there is a difference, for example, between seeing x and seeing that x is F. This distinction between simple and epistemic seeing is a staple of the philosophy of perception. Memory is often usefully compared to perception, and in this spirit I argue for the conditional claim that if Dretske’s arguments succeed in motivating the posit of simple seeing, then parallel arguments should equally motivate a posit I call simple remembering. Simple remembering would be a conscious form of memory about an object or event which is prior to and independent of any beliefs the subject may or may not form about the object or event simply remembered.
CKD prevalence based on real-world data: continuous age-dependent lower reference limits of eGFR with CKD–EPI, FAS and EKFC algorithms
Authors: Adler Jakob , Taneva Elina , Ansorge Thomas , Mertens Peter R.
Published: April 2022

Purpose

Several recent articles discuss the need for a definition of chronic kidney disease (CKD) that embarks age-dependency and its impact on the prevalence of CKD. The relevance is derived from the common knowledge that renal function declines with age. The aim of this study was to calculate age-dependent eGFR lower reference limits and to consider their impact on the prevalence of CKD.

Methods

A real-world data set from patients with inconspicuous urinalysis was used to establish two quantile regression models which were used to calculate continuous age-dependent lower reference limits of CKD–EPI, FAS and EKFC–eGFR based on either single eGFR determinations or eGFR values that are stable over a period of at least 3 months (± 10% eGFR). The derived lower reference limits were used to calculate the prevalence of CKD in a validation data set. Prevalence calculation was done once without and once with application of the chronicity criterion.

Results

Both models yielded age-dependent lower reference limits of eGFR that are comparable to previously published data. The model using patients with stable eGFR resulted in higher eGFR reference limits. By applying the chronicity criterion, a lower prevalence of CKD was calculated when compared to one-time eGFR measurements (CKD–EPI: 9.8% vs. 8.3%, FAS: 8.0% vs. 7.2%, EKFC: 9.0% vs. 7.1%).

Conclusion

The application of age-dependent lower reference intervals of eGFR together with the chronicity criterion result in a lower prevalence of CKD which supports the estimates of recently published work and the idea of introducing age-dependency into the definition of CKD.
4D Temporally Coherent Multi-Person Semantic Reconstruction and Segmentation
Authors: Mustafa Armin , Russell Chris , Hilton Adrian
Published: April 2022

We introduce the first approach to solve the challenging problem of automatic 4D visual scene understanding for complex dynamic scenes with multiple interacting people from multi-view video. Our approach simultaneously estimates a detailed model that includes a per-pixel semantically and temporally coherent reconstruction, together with instance-level segmentation exploiting photo-consistency, semantic and motion information. We further leverage recent advances in 3D pose estimation to constrain the joint semantic instance segmentation and 4D temporally coherent reconstruction. This enables per person semantic instance segmentation of multiple interacting people in complex dynamic scenes. Extensive evaluation of the joint visual scene understanding framework against state-of-the-art methods on challenging indoor and outdoor sequences demonstrates a significant ($$\approx 40\%$$

≈
40
%

) improvement in semantic segmentation, reconstruction and scene flow accuracy. In addition to the evaluation on several indoor and outdoor scenes, the proposed joint 4D scene understanding framework is applied to challenging outdoor sports scenes in the wild captured with manually operated wide-baseline broadcast cameras.
Changes in antioxidant system and sucrose metabolism in maize varieties exposed to Cd
Authors: Li Cong , Cao Yingdi , Li Tianfeng , Guo Meiyu , Ma Xinglin , Zhu Yanshu , Fan Jinjuan
Published: April 2022

Different maize varieties respond differentially to cadmium (Cd) stress. However, the physiological mechanisms that determine the response are not well defined. Antioxidant systems and sucrose metabolism help plants to cope with abiotic stresses, including Cd stress. The relationship of these two systems in the response to Cd stress is unclear. Seed is sensitive to Cd stress during germination. In this study, we investigated changes in the antioxidant system, sucrose metabolism, and abscisic acid and gibberellin concentrations in two maize varieties with low (FY9) or high (SY33) sensitivities to Cd under exposure to CdCl2 (20 mg L−1) at different stages of germination (3, 6, and 9 days).The seed germination and seedling growth were inhibited under Cd stress. The superoxide, malondialdehyde, and proline concentrations, and the superoxide dismutase, peroxidase, catalase, and lipoxygenase activities increased compared with those of the control (CK; without Cd). The expression levels of three genes (ZmOPR2, ZmOPR5, and ZmPP2C6) responsive to oxidative stress increased differentially in the two varieties under Cd stress. The activity of the antioxidant system and the transcript levels of oxidative stress–responsive genes were higher in the Cd-tolerant variety, FY9, than in the sensitive variety, SY33. Sucrose metabolism was increased under Cd stress compared with that of the CK and was more active in the Cd-sensitive variety, SY33. These results suggest that the antioxidant system is the first response to Cd stress in maize, and that sucrose metabolism is cooperative and complementary under exposure to Cd.
Supporting student motivation in class: the motivational potential of tasks
Authors: Heinle Anna , Schiepe-Tiska Anja , Reinhold Frank , Heine Jörg-Henrik , Holzberger Doris
Published: April 2022

Fostering student motivation is an important educational goal. However, motivation in the classrooms is rather heterogeneous, particularly in mathematics and physics. This study examines the potential of (textbook) tasks to promote student motivation. Based onself-determination theory(SDT) andtheory of interest, a low-inference coding scheme was developed and validated by applying the framework ofitem response theory(IRT) to assess the motivational potential of tasks. Current ninth grade mathematics and physics tasks (N = 254 task units) were analyzed using the categoriesdifferentiated instruction, real-life context, autonomy support, competence support, andsupport for relatedness. Additionally, differences between mathematics and physics tasks were examined. Results indicate the coding scheme’s high interrater reliabilities and empirical validity. Furthermore, we found only a low occurrence of motivational features in mathematics and physics tasks, with few subject-specific differences in favor of mathematics. The coding scheme can contribute to optimizing motivation-supportive instructional designs.
Secondary structure and 1H, 15 N & 13C resonance assignments of the periplasmic domain of OutG, major pseudopilin from Dickeya dadantii type II secretion system
Authors: Jacobsen Theis , Dazzoni Régine , Renault Melvin G. , Bardiaux Benjamin , Nilges Michael , Shevchik Vladimir , Izadi-Pruneyre Nadia
Published: April 2022

The ability to interact and adapt to the surrounding environment is vital for bacteria that colonise various niches and organisms. One strategy developed by Gram-negative bacteria is to secrete exoprotein substrates via the type II secretion system (T2SS). The T2SS is a proteinaceous complex spanning the bacterial envelope that translocates folded proteins such as toxins and enzymes from the periplasm to the extracellular milieu. In the T2SS, a cytoplasmic ATPase elongates in the periplasm the pseudopilus, a non-covalent polymer composed of protein subunits named pseudopilins, and anchored in the inner membrane by a transmembrane helix. The pseudopilus polymerisation is coupled to the secretion of substrates. The T2SS of Dickeya dadantii secretes more than 15 substrates, essentially plant cell wall degrading enzymes. In D. dadantii, the major pseudopilin or the major subunit of the pseudopilus is called OutG. To better understand the mechanism of secretion of these numerous substrates via the pseudopilus, we have been studying the structure of OutG by NMR. Here, as the first part of this study, we report the 1H, 15N and 13C backbone and sidechain chemical shift assignment of the periplasmic domain of OutG and its NMR derived secondary structure.
Do bigger egos mean bigger presence? Facets of grandiose narcissism and mindfulness
Authors: Fatfouta Ramzi , Heinze Peter Eric
Published: April 2022

Broad sections of the population try to be more mindful, often with quite self-centered motives. It is therefore not surprising that there is growing interest in the investigation of narcissism and mindfulness. Despite theoretical and empirical ties, however, existing research on this association is scarce. In two studies (N = 3,134 and 403) with English- and German-speaking participants, we apply structural equation modeling (SEM) to examine the relationships between facets of grandiose narcissism and trait mindfulness. Across both studies and, using different narcissism and mindfulness measures, SEM consistently revealed opposing patterns for agentic and antagonistic narcissism, with agentic narcissism being positively related to trait mindfulness, and antagonistic narcissism being negatively related to it. Findings highlight the necessity to acknowledge the conceptual heterogeneity of narcissism when examining its relationship with trait mindfulness. Practical implications regarding how agentic and antagonistic narcissists might profit differently from mindfulness practice are discussed.
Organic photodiode with dual functions of indoor photovoltaic and high-speed photodetector
Authors: Kim Tae Wook , Kim Sung Hyun , Shim Jae Won , Hwang Do Kyung
Published: April 2022

Energy harvesting and light detection are key technologies in various emerging optoelectronic applications. The high absorption capability and bandgap tunability of organic semiconductors make them promising candidates for such applications. Herein, a poly(3-hexylthiophene-2,5-diyl) (P3HT):indene-C60 bisadduct (ICBA) bulk heterojunction-based organic photodiode (OPD) was reported, demonstrating dual functionality as an indoor photovoltaic (PV) and as a high-speed photodetector. This OPD demonstrated decent indoor PV performance with a power conversion efficiency (PCE) of (11.6 ± 0.5)% under a light emitting diode (LED) lamp with a luminance of 1000 lx. As a photodetector, this device exhibited a decent photoresponsivity of 0.15 A/W (green light) with an excellent linear dynamic range (LDR) of over 127 dB within the optical power range of 3.74 × 10−7 to 9.6 × 10−2 W/cm2. Furthermore, fast photoswitching behaviors could be observed with the rising/falling times of 14.5/10.4 μs and a cutoff (3 dB) frequency of 37 kHz. These results might pave the way for further development of organic optoelectronic applications.

Graphical Abstract
ESMO 2021—highlights in colorectal cancer
Authors: Weiss Lukas
Published: April 2022

This short review reflects on a personal selection of three abstracts on colorectal cancer (CRC) presented at the 2021 ESMO Congress: (1) KRASG12C as a new therapeutic target in metastatic CRC, supported by data from the KRYSTAL‑1 and CodeBreaK101 trials, (2) positive phase 3 data on the possible role of selective internal radiotherapy (SIRT) in the second-line treatment of liver-limited metastatic CRC, and (3) the impact of the coronavirus disease 2019 (COVID-19) pandemic on CRC screening, management and mortality, now and in the upcoming years.
Cultural differences in processing online customer reviews: holistic versus analytic thinkers
Authors: Brand Benedikt M. , Kopplin Cristopher Siegfried , Rausch Theresa Maria
Published: April 2022

While the majority of studies exploring online customer reviews in the light of intercultural comparisons draw on the theoretical framework of Hofstede’s cultural dimensions, which faced justifiable criticism, we make use of Socio-Cognitive Systems Theory to illustrate how consumers from different cultures are cognitively processing information. By employing this alternative theory, it is shown that the (heretofore established) Elaboration Likelihood Model for examining online customer reviews does not serve as an applicable framework in intercultural contexts. Reviewing extant literature, we uncover incidents questioning the generalizability of previous studies on review credibility conducted among East Asians. Building upon a research model established at a national level, we interviewed Western (German; n=552) and East Asian (Chinese; n=585) consumers to analyze the intercultural appropriateness of the model. The results empirically validate the assumptions of the Socio-Cognitive Systems Theory, and thus, finds Chinese to perceive review credibility holistically, whereas Germans tend to categorize its antecedents for evaluating them separately.
Deep learning in radiology: ethics of data and on the value of algorithm transparency, interpretability and explainability
Authors: Fernandez-Quilez Alvaro
Published: April 2022

AI systems are quickly being adopted in radiology and, in general, in healthcare. A myriad of systems is being proposed and developed on a daily basis for high-stake decisions that can lead to unwelcome and negative consequences. AI systems trained under the supervised learning paradigm greatly depend on the quality and amount of data used to develop them. Nevertheless, barriers in data collection and sharing limit the data accessibility and potential ethical challenges might arise due to them leading, for instance, to systems that do not offer equity in their decisions and discriminate against certain patient populations or that are vulnerable to appropriation of intellectual property, among others. This paper provides an overview of some of the ethical issues both researchers and end-users might meet during data collection and development of AI systems, as well an introduction to the current state of transparency, interpretability and explainability of the systems in radiology applications. Furthermore, we aim to provide a comprehensive summary of currently open questions and identify key issues during the development and deployment of AI systems in healthcare, with a particular focus on the radiology area.
Inoculating the University R&D Enterprise: How RISC can strengthen post-COVID-19 research integrity and global supply chains
Authors: Norris William J. , Vaughan-Naron Katie , Kashyap Neha , Rodgers Joseph Balmain
Published: April 2022

The COVID-19 pandemic has underscored emerging vulnerabilities in the US research and development (R&D) ecosystem. While an open and collaborative environment has been essential for advancing R&D, this approach exposes university-based R&D to a variety of security threats including state-supported efforts, attacks by malicious actors, and insufficient internal mitigation. As the pandemic led to more remote work and online collaboration, the incidence of exploitation has expanded. Increased security measures are needed to insulate and protect the R&D ecosystem, and US innovation more broadly, while maintaining the fundamental qualities that have contributed to its historical success. In this article, we present the Research Integrity Security Certification (RISC) framework. This concept preserves the autonomy of the US higher education system while also suggesting a mechanism whose effect would be a general enhancement of the security of the US university R&D enterprise with minimal additional state involvement. Much of the work in the proposed model is done by market mechanisms and self-interested microeconomic calculations that generate beneficial aggregate effects. The RISC framework modernizes the university R&D enterprise while strengthening it to operate in this evolving security environment.
Multi-scale dynamics of Kelvin–Helmholtz instabilities. Part 1. Secondary instabilities and the dynamics of tubes and knots
Authors: Fritts David C. , Wang L. , Lund T.S. , Thorpe S.A.
Published: April 2022

We perform a direct numerical simulation (DNS) of interacting Kelvin–Helmholtz instabilities (KHI) that arise at a stratified shear layer where KH billow cores are misaligned or exhibit varying phases along their axes. Significant evidence of these dynamics in early laboratory shear-flow studies by Thorpe (Geophys. Astrophys. Fluid Dyn., vol. 34, 1985, pp. 175–199) and Thorpe (J. Geophys. Res., vol. 92, 1987, pp. 5231–5248), in observations of KH billow misalignments in tropospheric clouds (Thorpe, Q. J. R. Meteorol. Soc., vol. 128, 2002, pp. 1529–1542) and in recent direct observations of such events in airglow and polar mesospheric cloud imaging in the upper mesosphere reveals that these dynamics are common. More importantly, the laboratory and mesospheric observations suggest that these dynamics lead to more rapid and more intense instabilities and turbulence than secondary convective instabilities in billow cores and secondary KHI in stratified braids between and around adjacent billows. To date, however, no simulations exploring the dynamics and energetics of interacting KH billows (apart from pairing) have been performed. Our DNS performed for Richardson number

$Ri=0.10$

and Reynolds number

$Re=5000$

demonstrates that KHI tubes and knots (i) comprise strong and complex vortex interactions accompanying misaligned KH billows, (ii) accelerate the transition to turbulence relative to secondary instabilities of individual KH billows, (iii) yield significantly stronger turbulence than secondary KHI in billow braids and secondary convective instabilities in KHI billow cores and (iv) expand the suite of secondary instabilities previously recognized to contribute to KHI dynamics and breakdown to turbulence in realistic geophysical environments.
Origin of enhanced skin friction at the onset of boundary-layer transition
Authors: Wang Mengze , Eyink Gregory L. , Zaki Tamer A.
Published: April 2022

Boundary-layer transition is accompanied by a significant increase in skin friction whose origin is rigorously explained using the stochastic Lagrangian formulation of the Navier–Stokes equations. This formulation permits the exact analysis of vorticity dynamics in individual realizations of a viscous incompressible fluid flow. The Lagrangian reconstruction formula for vorticity is here extended for the first time to Neumann boundary conditions (Lighthill source). We can thus express the wall vorticity, and, therefore, the wall stress, as the expectation of a stochastic Cauchy invariant in backward time, with contributions from (a) wall vorticity flux (Lighthill source) and (b) interior vorticity that has been evolved by nonlinear advection, viscous diffusion, vortex stretching and tilting. We consider the origin of stress maxima in the transitional region, examining a sufficient number of events to represent the increased skin friction. The stochastic Cauchy analysis is applied to each event to trace the origin of the wall vorticity. We find that the Lighthill source, vortex tilting, diffusion and advection of the outer vorticity make minor contributions. They are less important than spanwise stretching of near-wall spanwise vorticity, which is the dominant source of skin-friction increase during laminar-to-turbulent transition. Our analysis should assist more generally in understanding drag generation and reduction strategies and flow separation in terms of near-wall vorticity dynamics.
The Gender Pay Gap and High-Achieving Women in the Legal Profession
Authors: Markovic Milan , Plickert Gabriele
Published: April 2022

Although women have made significant strides in the legal profession, female attorneys continue to earn far less than male attorneys. Relying on survey data from a large sample of full-time attorneys in Texas, we find a gender pay gap of thirty-five thousand dollars at the median that cannot be explained by differences in human capital or occupational segregation. We also provide evidence that the legal market especially disadvantages women who excel in law school. Whereas high academic achievement boosts male lawyers’ incomes substantially, it does not have the same effect on female lawyers’ incomes. High-achieving female lawyers earn less than high-achieving male lawyers across practice settings and earn less than their lower-achieving male counterparts in private practice. We conclude that discrimination in the legal profession operates partly by devaluing female attorneys’ human capital, such that sterling academic credentials and other traits that are valued in men are far less valued in women.
Electoral Double-Bind: How Electoral Environments Affect Racial and Ethnic Youth Voting Behavior
Authors: Coll Joseph A. , Juelich Courtney L.
Published: April 2022

Previous research on the voting propensity of young Americans has largely treated the effects of state electoral laws as homogenous, despite today’s youth belonging to the most racially and ethnically diverse age cohort to date. Research has documented differences in participatory resources across racial, ethnic, and age groups, with recent work also suggesting differences in racial and ethnic identity influences across age groups. These factors may lead to significant differences in voter turnout under different state electoral environments. Using the Current Population Survey (2000–2016), national voter rolls (2012), and the Cost of Voting Index, this study investigates how the intersectionality of age and racial/ethnic identification affect voting decisions across state electoral environments. Whether comparing young voters across racial/ethnic identifications or comparing young voters to their older racial/ethnic counterparts, results strongly support the assertion that young voters are affected to differing degrees by increased costs to vote along racial/ethnic lines.
Medicine and the heavens in Padua's Faculty of Arts, 1570–1630
Authors: Martin Craig
Published: April 2022

In the faculty of arts at the University of Padua in the years around 1600 professors debated the reliability of astrology, the existence of occult celestial influences, and the idea that celestial heat is present in living bodies. From the 1570s to the 1620s many professors in the faculty of arts pushed back against astrology and Jean Fernel's theories surrounding astral body. Girolamo Mercuriale, Alessandro Massaria and Eustachio Rudio thought that some forms of astral causation and Fernel's ideas were incompatible with their observations of disease, Aristotle's philosophy and Hippocratic theories. Later, Santorio Santorio and Cesare Cremonini, who were allied to the political circle of Paolo Sarpi, polemicized against astrology. Their writings show that at Padua medical theory was linked to Aristotelian cosmology, which emphasized the incommensurability between celestial and terrestrial elements. Their rejection of astrology, however, did not lead to the complete marginalization of astrology at Padua. By the middle of the 1620s, as the political climate changed in Venice, the University of Padua hired professors who promoted astrology and Fernel's theories about the celestial nature of innate heat. The diversity of opinions about astrology reflected Venice's divided politics and multiple approaches to interpreting Aristotle and other authorities.
A closer look at a marginalized test method: Self-assessment as a measure of speaking proficiency
Authors: Winke Paula , Zhang Xiaowan , Pierce Steven J.
Published: April 2022

Second language (L2) teachers may shy away from self-assessments because of warnings that students are not accurate self-assessors. This information stems from meta-analyses in which self-assessment scores on average did not correlate highly with proficiency test results. However, researchers mostly used Pearson correlations, when polyserial could be used. Furthermore, self-assessments today can be computer adaptive. With them, nonlinear statistics are needed to investigate their relationship with other measurements. We wondered, if we explored the relationship between self-assessment and proficiency test scores using more robust measurements (polyserial correlation, continuation-ratio modeling), would we find different results? We had 807 L2-Spanish learners take a computer-adaptive, L2-speaking self-assessment and the ACTFL Oral Proficiency Interview – computer (OPIc). The scores correlated at .61 (polyserial). Using continuation-ratio modeling, we found each unit of increase on the OPIc scale was associated with a 131% increase in the odds of passing the self-assessment thresholds. In other words, a student was more likely to move on to higher self-assessment subsections if they had a higher OPIc rating. We found computer-adaptive self-assessments appropriate for low-stakes L2-proficiency measurements, especially because they are cost-effective, make intuitive sense to learners, and promote learner agency.
Building Nations After Empire: Post-Imperial Migrations to Portugal in a Western European Context
Authors: Kalter Christoph
Published: April 2022

Building on original research and dialoguing with scholarly works on Portugal, France and the United Kingdom, this article argues that decolonisation and migrations from the (former) colonies triggered and moulded a new, post-imperial nation-building in Western Europe. Analysing the highly significant but hitherto much-neglected case of Portugal in its broader Western European context, this claim is substantiated by surveying how these migrations affected citizenship and notions of the national community, the welfare state and public memories. Comparative and relational in its approach, the article links the histories of white ‘returnees’ from Portugal's African colonies after the 1974 Carnation Revolution to those of non-white ‘immigrants’, arguing that we must situate in the same analytical field all those who migrated from (formerly) colonised territories to the metropole during the drawn-out end of empire.