bluuebunny/crossref_metadata_2025 huggingface dataset:
Phytoremediation of Gold Mine Tailings Amended with Iron-Coated and Uncoated Rice Husk Ash by Vetiver Grass (Vetiveria zizanioides(Linn.) Nash)
Authors: Tariq F. S. , Samsuri A. W. , Karam D. S. , Aris A. Z.
Published: May 2016

This study was undertaken to determine the effects of rice husk ash (RHA) and iron-coated rice husk ash (Fe-RHA) on phytoavailability of As, Cd, Cr, Cu, Mn, Pb, and Zn to vetiver grass grown in gold mine tailings amended with either RHA or Fe-RHA at 0%, 5%, 10%, and 20% (w/w). The results showed that the RHA amended tailings recorded higher concentration of As in the shoot and the root and higher concentration of Cr and Mn in the root compared to the untreated tailings which was used as a control. The biological accumulation coefficient (BAC) and bioconcentration factor (BCF) values of the vetiver grass for As and Zn increased with RHA application rate but the biological transfer coefficient (BTC) values of As and Zn were decreased. In Fe-RHA amended samples, As concentration in the shoot and root concentrations of Cd and Zn were significantly higher compared to the control. The Fe-RHA treated samples had lower BAC and BTC values for As and Zn than the control. However, the BCF values for those elements were higher than the control. The concentration of Pb was not detected in any of the samples.
Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice
Authors: Jessberger Jakob , Zhong Weiwei , Brankačk Jurij , Draguhn Andreas
Published: May 2016

It is well established that local field potentials (LFP) in the rodent olfactory bulb (OB) follow respiration. This respiration-related rhythm (RR) in OB depends on nasal air flow, indicating that it is conveyed by sensory inputs from the nasal epithelium. Recently RR was found outside the olfactory system, suggesting that it plays a role in organizing distributed network activity. It is therefore important to measure RR and to delineate it from endogenous electrical rhythms like theta which cover similar frequency bands in small rodents. In order to validate such measurements in freely behaving mice, we compared rhythmic LFP in the OB with two respiration-related biophysical parameters: whole-body plethysmography (PG) and nasal temperature (thermocouple; TC). During waking, all three signals reflected respiration with similar reliability. Peak power of RR in OB decreased with increasing respiration rate whereas power of PG increased. During NREM sleep, respiration-related TC signals disappeared and large amplitude slow waves frequently concealed RR in OB. In this situation, PG provided a reliable signal while breathing-related rhythms in TC and OB returned only during microarousals. In summary, local field potentials in the olfactory bulb do reliably reflect respiratory rhythm during wakefulness and REM sleep but not during NREM sleep.
Lattice Boltzmann Simulation of Airflow and Mixed Convection in a General Ward of Hospital
Authors: Himika Taasnim Ahmed , Hasan Md. Farhad , Molla Md. Mamun
Published: May 2016

In the present investigation the airflow and heat transfer for mixed convection have been simulated for a model general ward of hospital with six beds and partitions using the Lattice Boltzmann Method (LBM). Three different Reynolds numbers 100, 250, and 350 have been considered. Bounce-back condition has been applied at the wall. Results have been represented in three different case studies and the changes have been discussed in terms of streamlines and isotherms. Code validation has also been included before going through the simulation process and it shows good agreement with previously published papers when the comparison is made on average Nusselt number. Results show that the pattern of indoor airflow is varied in each and every case study due to the effect of mixed convection flow and placement of partition. In addition, the changes in average rate of heat transfer indicate that patients closer to inlet get the most air and feel better and if any patient does not need much air, he or she should be kept near the outlet to avoid temperature related complications.
Processing and Quality Evaluation of Additive Manufacturing Monolayer Specimens
Authors: Wendt Christiane , Fernández-Vidal Severo Raúl , Gómez-Parra Álvaro , Batista Moisés , Marcos Mariano
Published: May 2016

Although its importance has increased significantly, Additive Manufacturing is not yet a fully accepted industrial manufacturing process for load-carrying parts. The future success of the process group depends on its standardization. This work proposes a methodology for the design, manufacturing, and quality evaluation of specimens manufactured by Fused Layer Modeling that are composed of only one layer (so-called monolayers). The processing methodology and properties of monolayers have not been studied systematically yet. A first systematic design of monolayers for mechanical testing is presented. Rectangular and circular monolayers adapted to the loads of tensile and compression testing are manufactured using different trajectory strategies. Frequently occurring macro- and microgeometrical defects are evaluated and categorized in order to optimize the part quality. This work also studies the effect of some manufacturing parameters such as the gap between print head and machine bed, trajectory strategy, bed leveling, and temperatures on part quality. The most suitable specimens are tested mechanically in tensile or compression tests. In the case of study, tensile strength values are only 8.6% lower than the values for reference tests on the unextruded filament. However, the properties deviate more strongly for compression tests which may be due to the selected specimen geometry.
Comparative Multifractal Detrended Fluctuation Analysis of Heavy Ion Interactions at a Few GeV to a Few Hundred GeV
Authors: Bhoumik Gopa , Deb Argha , Bhattacharyya Swarnapratim , Ghosh Dipak
Published: May 2016

We have studied the multifractality of pion emission process in16O-AgBr interactions at 2.1 AGeV  and  60 AGeV,12C-AgBr  and  24Mg-AgBr interactions at 4.5 AGeV, and32S-AgBr interactions at 200 AGeV using Multifractal Detrended Fluctuation Analysis (MFDFA) method which is capable of extracting the actual multifractal property filtering out the average trend of fluctuation. The analysis reveals that the pseudorapidity distribution of the shower particles is multifractal in nature for all the interactions; that is, pion production mechanism has inbuilt multiscale self-similarity property. We have employed MFDFA method for randomly generated events for32S-AgBr interactions at 200 AGeV. Comparison of expt. results with those obtained from randomly generated data set reveals that the source of multifractality in our data is the presence of long range correlation. Comparing the results obtained from different interactions, it may be concluded that strength of multifractality decreases with projectile mass for the same projectile energy and for a particular projectile it increases with energy. The values of ordinary Hurst exponent suggest that there is long range correlation present in our data for all the interactions.
Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation
Authors: Vennepureddy A. , Motilal Nehru V. , Liu Y. , Mohammad F. , Atallah J. P.
Published: May 2016

The cooccurrence of more than one oncologic illness in a patient can present a diagnostic challenge. Here we report an unusual case of concomitant existence of multiple myeloma, breast cancer, and monoclonal B-cell lymphocytosis on initial presentation. The challenge was to accurately diagnose each disease and stage in order to maximize the therapeutic regimen to achieve cure/remission. Successful management of the patient and increased life expectancy can be achieved by multidisciplinary management and patient-oriented approach in multiple primary malignant synchronous tumors.
Severe Psychosis, Drug Dependence, and Hepatitis C Related toSlammingMephedrone
Authors: Dolengevich-Segal Helen , Rodríguez-Salgado Beatriz , Gómez-Arnau Jorge , Sánchez-Mateos Daniel
Published: May 2016

Background. Synthetic cathinones (SCs), also known as “bath salts,” areβ-ketone amphetamine compounds derived from cathinone, a psychoactive substance found inCatha edulis. Mephedrone is the most representative SC.Slammingis the term used for the intravenous injection of these substances in the context ofchemsexparties, in order to enhance sex experiences. Using IV mephedrone may lead to diverse medical and psychiatric complications like psychosis, aggressive behavior, and suicide ideation.Case. We report the case of a 25-year-old man admitted into a psychiatric unit, presenting with psychotic symptoms afterslammingmephedrone almost every weekend for the last 4 months. He presents paranoid delusions, intense anxiety, and visual and kinesthetic hallucinations. He also shows intense craving, compulsive drug use, general malaise, and weakness. After four weeks of admission and antipsychotic treatment, delusions completely disappear. The patient is reinfected with hepatitis C.Discussion. Psychiatric and medical conditions related tochemsexandslamminghave been reported in several European cities, but not in Spain. Psychotic symptoms have been associated with mephedrone and other SCs’ consumption, with the IV route being prone to produce more severe symptomatology and addictive conducts. In the case we report, paranoid psychosis, addiction, and medical complications are described.
Review of Anti-Inflammatory Herbal Medicines
Authors: Ghasemian Mona , Owlia Sina , Owlia Mohammad Bagher
Published: May 2016

Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies.Curcuma longa, Zingiber officinale, Rosmarinus officinalis, Borago officinalis, evening primrose, and Devil’s claw are some of the introduced medicinal herbs in this review. Since the treatment of inflammation is not a one-dimensional remedy, this review tries to reach a multidimensional therapeutic approach to inflammation with the help of herbal medicine and modification in lifestyle.
Synthesis of Novel Derivatives of Carbazole-Thiophene, Their Electronic Properties, and Computational Studies
Authors: Damit E. F. , Nordin N. , Ariffin A. , Sulaiman K.
Published: May 2016

A series of carbazole-thiophene dimers,P1–P9, were synthesized using Suzuki-Miyaura and Ullmann coupling reactions. InP1–P9, carbazole-thiophenes were linked at the N-9 position for different core groups via biphenyl, dimethylbiphenyl, and phenyl. Electronic properties were evaluated by UV-Vis, cyclic voltammogram, and theoretical calculations. Particularly, the effects of conjugation connectivity on photophysical and electrochemical properties, as well as the correlation between carbazole-thiophene and the core, were studied. Carbazole connecting with thiophenes at the 3,6-positions and the phenyl group as a core group leads to increased stabilization of HOMO and LUMO energy levels where the bandgap (ΔE) is significantly reduced.
Resection and Abdominal Wall Reconstruction of a Desmoid Tumor with Endometrioma Features
Authors: Majors Jaqueline , Stoikes Nathaniel F. , Nejati Reza , Deneve Jeremiah L.
Published: May 2016

Desmoid tumors are rare, musculoaponeurotic mesenchymal origin tumors arising from the proliferation of well-differentiated fibroblasts. Desmoid tumors may arise from any location with the abdominal cavity, abdominal wall and extremity locations being most frequent. We present the case of a 35-year-old female with a history of endometriosis who presented palpable abdominal mass and cyclic abdominal pain. Resection was performed for a presumed desmoid soft tissue tumor. Final pathology demonstrated desmoid histology admixed with abdominal wall endometriosis (endometrioma). This unique pathologic finding has only been rarely reported and is discussed with a brief review of the literature.
FOXM1 and FOXQ1 Are Promising Prognostic Biomarkers and Novel Targets of Tumor-Suppressive miR-342 in Human Colorectal Cancer
Authors: Weng Wenhao , Okugawa Yoshinaga , Toden Shusuke , Toiyama Yuji , Kusunoki Masato , Goel Ajay
Published: May 2016

Purpose: Colorectal cancer ranks as the third most frequent cancer type, and its incidence continues to rise gradually worldwide, highlighting the need to identify previously unrecognized molecular events that propel development of this malignancy. Recent evidence suggests that dysregulated expression of FOX family of transcription factors may be critical in various genetic disorders as well as cancer; however, the functional and clinical significance of this pathway in colorectal cancer remains unclear.

Experimental Design and Results: Herein, we performed a systematic and comprehensive discovery step by evaluating the expression of FOX family members, and identified that FOXM1 and FOXQ1 are frequently overexpressed in colorectal cancer. We subsequently confirmed these findings in two large testing cohorts (n = 550) and an independent clinical validation cohort (n = 134), in which high expression of FOXM1 and FOXQ1 emerged as an independent prognostic factor in colorectal cancer patients. We corroborated these findings by performing functional assays in which knockdown of FOXM1 and FOXQ1 resulted in inhibited cell proliferation and suppressed migration and invasion in colorectal cancer cells. Furthermore, using bioinformatic approaches, we identified miR-342 as a novel regulator of both FOXM1 and FOXQ1. Overexpression or inhibition of miR-342 modulated the expression of both genes and contributed to phenotypic alterations in colorectal cancer cells, which was subsequently validated in a xenograft animal model.

Conclusions: Collectively, we have firstly identified FOXM1 and FOXQ1 as promising prognostic biomarkers in colorectal cancer patients, and provided novel evidence that therapeutic targeting of these genes or miR-342 may be a potential treatment approach in colorectal cancer patients. Clin Cancer Res; 22(19); 4947–57. ©2016 AACR.
Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions
Authors: Kashyap Abhishek S. , Shooter Gary K. , Shokoohmand Ali , McGovern Jacqui , Sivaramakrishnan Manaswini , Croll Tristan I. , Cane Gaëlle , Leavesley David I. , Söderberg Ola , Upton Zee , Hollier Brett G.
Published: May 2016

We provide proof-of-concept evidence for a new class of therapeutics that target growth factor:extracellular matrix (GF:ECM) interactions for the management of breast cancer. Insulin-like growth factor-I (IGF-I) forms multiprotein complexes with IGF-binding proteins (IGFBP) and the ECM protein vitronectin (VN), and stimulates the survival, migration and invasion of breast cancer cells. For the first time we provide physical evidence for IGFBP-3:VN interactions in breast cancer patient tissues; these interactions were predominantly localized to tumor cell clusters and in stroma surrounding tumor cells. We show that disruption of IGF-I:IGFBP:VN complexes with L27-IGF-II inhibits IGF-I:IGFBP:VN-stimulated breast cancer cell migration and proliferation in two- and three-dimensional assay systems. Peptide arrays screened to identify regions critical for the IGFBP-3/-5:VN and IGF-II:VN interactions demonstrated IGFBP-3/-5 and IGF-II binds VN through the hemopexin-2 domain, and VN binds IGFBP-3 at residues not involved in the binding of IGF-I to IGFBP-3. IGFBP-interacting VN peptides identified from these peptide arrays disrupted the IGF-I:IGFBP:VN complex, impeded the growth of primary tumor-like spheroids and, more importantly, inhibited the invasion of metastatic breast cancer cells in 3D assay systems. These studies provide first-in-field evidence for the utility of small peptides in antagonizing GF:ECM-mediated biologic functions and present data demonstrating the potential of these peptide antagonists as novel therapeutics. Mol Cancer Ther; 15(7); 1602–13. ©2016 AACR.
Pericyte Status in Routinely Discarded Vitrectomy Samples May Be an Early Marker of Diabetic Retinopathy
Authors: Zoroquiain Pablo , Vila Natalia , Bravo-Filho Vasco , Dias Ana Beatriz T. , Sanft Debra M. , Chen John , Galic John , Kapusta Michael , Mastromonaco Christina , Aldrees Sultan S. , Burnier Julia , Burnier Jr. Miguel N.
Published: May 2016

Background: Diabetic retinopathy (DR) is the leading cause of blindness among the working-age population. The earliest morphological manifestation of the disease is pericyte loss, as shown by animal models. Aims: The purpose of this study was to evaluate the presence of pericytes in vitreous samples (VS) from diabetic and nondiabetic patients. Methods: VS from 125 patients with and without diabetes were analyzed. Thirty-three of the VS contained blood vessels and were therefore included in further analysis. Pericyte status was evaluated using α-smooth muscle actin and quantified using the following scoring system: total loss (3), >50% loss (2), <50% loss (1), and no loss (0). Results: Of the 33 VS, 29 samples were from patients with diabetes and 4 from nondiabetic patients. Six diabetic cases had a score of 1, 8 diabetic cases had a score of 2, and 15 cases had a score of 3. A positive correlation between glycemia levels and pericyte loss was observed (p = 0.0016; Spearman's r = 0.61). Moreover, all nondiabetic cases had a score of 0 (sensitivity and specificity = 100%). Conclusion: Pericyte loss in VS might be a sensitive and specific marker of DR that correlates with glycemia levels. Furthermore, VS, which are currently discarded, may contain valuable information for diabetic management.
Inhibition of Cardiomyogenesis in Embryocarcinoma Cells Induced by Long-Term High Level of Glucose
Authors: Li Wen-Juan , Guo Qian-Qian , Gharibeh Lara , Xu Rang , Chen Sun , Sun Kun
Published: May 2016

Background/Aims: Cardiac myocytes constitute the first differentiated cell type during mammalian heart formation with the ability to beat spontaneously and rhythmically. Hyperglycemia is a primary risk factor for cardiovascular disease in pre-gestational diabetes mellitus (PGDM). However, the impact that hyperglycemia has on cardiac progenitors or on precursors differentiation remains poorly understood. The aim of the present study is to investigate whether hyperglycemia affects cardiomyogenesis of embryocarcinoma cells. Methods: P19CL6 cells differentiation induced by 1% DMSO was evaluated under either normal glucose (5.6 mmol/L) or high level of glucose concentrations (20 mmol/L or 40 mmol/L). To investigate the effect of long-term high level of glucose on cardiomyocytes differentiation, sarcomeric α-actinin, peroxisome proliferator-activated receptor coactivator-1 (PGC-1α), transcription factor GATA4 and Nkx2.5 were assessed by qRT-PCR analysis, western blot and immunofluorescence. Results: We observed that long-term high level of glucose markedly reduced P19CL6 cells differentiation into cardiomyocytes. The change in PGC-1α expression was consistent with changes in cardiac muscle myosin expression after exposure to 20 mmol/L or 40 mmol/L of glucose. On the other hand, the high level of glucose concentration profoundly decreased both GATA4 and Nkx2-5 expressions from day 6 to day 12 after differentiation, which was induced by 1% DMSO. Conclusion: Our results elucidate that the effect resulting from the long-term exposure of cardiac progenitors to high level of glucose is associated with decreased expression of GATA4 and Nkx2.5, providing a novel mechanism by which high glucose is able to affect cell differentiation.
Effects of Vitrification on Outcomes of In VivoMature, In Vitro-Mature and Immature Human Oocytes
Authors: Song Wen-yan , Peng Zhao-feng , Chen Xue-mei , Jin Hai-xia , Yao Gui-dong , Shi Sen-lin , Yang Hong-yi , Zhang Xiang-yang , Sun Ying-pu
Published: May 2016

Background/Aims: To observe the effects of vitrification on spindle, zona pellucida, embryonic aneuploidy and DNA injury in in vivo-maruted, in vitro-mature and immature human oocytes. Methods: Between January 2009 and February 2015, 223 immature oocytes from 450 infertile patients, and 31 in vivo-mature oocytes from 3 infertile couples were collected. Of the 223 immature oocytes, 113 were used for in vitro culture before vitrification. Some oocytes were randomly divided into in vivo-mature group (group A, n = 15), in vitro-mature group (group B, n = 88) and immature group (group C, n = 85), and then the oocytes with spindle in these three groups after freezing-thawing were selected to use for Polscope imaging, embryonic aneuploidy screening and embryo development evaluation. Other oocytes were randomly divided into group A (n = 16), group B (n = 25) and group C (n = 25) for detecting DNA injury. Results: After thawing, spindle occurrence rate, spindle Retardance value, and cleavage rate were significantly higher in groups A and B than in group C (all P < 0.05), but there were no statistical differences in fertility rate, high-quality embryo rate, blastulation rate and aneuploidy rate amongst the three groups (all P > 0.05). Zona pellucida density (ZPD) was significantly lower in group A than in groups B and C both before and after vitrification (all P < 0.05). ZPD was significantly higher after thawing than before vitrification (all P < 0.05), but zona pellucida thickness (ZPT) was not significantly changed in all the three groups (all P > 0.05). Rate of comet cells was significantly lower in group A than in groups B and C (all P < 0.01). Comet tail was significantly longer in group C than in groups B and A (all P < 0.05). Conclusion: In vivo- and in vitro-mature human oocytes are more suitable to vitrification than immature human oocytes. Spindle Retardance value has more predictive value for embryonic development potential than ZPD and ZPT.
Long-Term Follow-Up Case of Multiple Retinal Arterial Macroaneurysms Developing Branch Retinal Vein Occlusion following Ruptured Macroaneurysm
Authors: Terubayashi Yuya , Kida Teruyo , Fukumoto Masanori , Sugasawa Jun , Morishita Seita , Suzuki Hiroyuki , Ikeda Tsunehiko
Published: May 2016

Purpose: Retinal arterial macroaneurysm (RAM) has been reported in association with branch retinal vein occlusion (BRVO), and usually BRVO precedes RAM. We present a long-term follow-up case report of unilateral multiple RAMs that developed BRVO following ruptured RAM in the same retinal quadrant. Case Presentation: An 80-year-old woman presented with floaters in her right eye in June 2012. Visual acuity (VA) was 20/25 in her right eye with posterior capsular opacity. Her fundus showed the first ruptured RAM at the superotemporal vascular arcade with subinternal limiting membrane and subretinal hemorrhages not involving the macula. These were absorbed gradually with a VA of 20/20. After 2 years, the second RAM at the proximal superotemporal vascular arcade developed and impending BRVO occurred with macular edema at the distal site of the RAM. With the RAM located close to the arteriovenous crossing, her VA was dropped to 20/60. Intravitreal injection of ranibizumab was performed and macular edema was resolved with improved vision of 20/30. Three months later, she realized a sudden vision loss of 2/200. Her posterior pole showed massive pre- and subretinal hemorrhages, and vitrectomy was performed. The source of bleeding was the third RAM’s rupture in a different artery. Her vision improved to 20/30. The unaffected eye showed no RAMs. Conclusion: We experienced a long-term follow-up case of multiple RAMs showing different courses. We should cautiously note that BRVO can occur following RAM at the arteriovenous crossing.
Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised
Authors:   Executive Committee of the German Medical Association on the Recommendation of the Scientific Advisory Board
Published: May 2016

Chapter 5 ‘Human Albumin' that was suspended on January 10, 2011 has been completed and updated in the present version.
Lacrimal Sac Mucoepidermoid Carcinoma with Metastases to the Cavernous Sinus Following Dacryocystorhinostomy Treated with Stereotactic Radiotherapy
Authors: Roos Jonathan C.P. , Beigi Bijan
Published: May 2016

Purpose: We report a very good outcome in a 44-year-old woman in whom cancer was missed as the cause of nasolacrimal duct obstruction and dacryocystitis and which was deemed inoperable after spreading to the cavernous sinus. Case Report: The patient was referred to our unit 12 months following uneventful right dacryocystorhinostomy for nasolacrimal duct obstruction. This had been complicated by the formation of a significant canthal swelling 6 months later, which had been excised at that time. The symptom of nasolacrimal duct obstruction and scar recurrence prompted the referral to our unit. Examination and biopsy confirmed a malignancy. Despite extensive surgery, including concurrent radical neck dissection and parotidectomy, within 6 months, her mucoepidermoid carcinoma was found to have spread to the cavernous sinus, restricting blood flow from the carotid and causing an abducens nerve palsy. Though deemed inoperable at first, Gamma Knife stereotactic radiosurgery was sought as treatment for her disease, resulting in a good outcome 4 years after surgery. Conclusion: Experience from this case suggests the importance of considering malignancy as a cause in young patients when presenting with nasolacrimal duct obstruction. In such cases, and perhaps for all patients, biopsy specimens should be submitted as many tumours are found incidentally at the time of dacryocystorhinostomy. Whilst the external approach to dacryocystorhinostomy may identify abnormal anatomy intraoperatively, prompting biopsy, this is less likely with an endonasal approach where osteotomy precedes sac visualisation. The endonasal approach may therefore be less appropriate in such cases where malignancy is suspected as osteotomy may aid in the spread.
Nebivolol versus Carvedilol or Metoprolol in Patients Presenting with Acute Myocardial Infarction Complicated by Left Ventricular Dysfunction
Authors: Ozaydin Mehmet , Yucel Habil , Kocyigit Sule , Adali Mehmet Koray , Aksoy Fatih , Kahraman Fatih , Uysal Bayram Ali , Erdogan Dogan , Varol Ercan , Dogan Abdullah
Published: May 2016

Objective: The aim of this study was to evaluate the efficacy of nebivolol, carvedilol or metoprolol succinate on the outcome of patients presenting with acute myocardial infarction (AMI) complicated by left ventricular dysfunction. Subjects and Methods: Patients (n = 172, aged 28-87 years) with AMI and left ventricular ejection fraction ≤0.45 were randomized to the nebivolol (n = 55), carvedilol (n = 60) and metoprolol succinate (n = 57) groups. Baseline demographic and clinical characteristics and composite event rates of nonfatal MI, cardiovascular mortality, hospitalization due to unstable angina pectoris or heart failure, stroke or revascularization during the 12-month follow-up were compared among the groups using the χ2 test, t test or log-rank test as appropriate. Results: Baseline demographic and clinical characteristics were similar in the three groups. The composite end point during follow-up was lower in the patients treated with nebivolol than those treated with metoprolol (14.5 vs. 31.5%; p = 0.03). However, event rates were similar between the patients treated with carvedilol and those treated with the metoprolol (20.3 vs. 31.5%, p > 0.05) and between the patients treated with nebivolol and carvedilol (14.5 vs. 20.3%, p > 0.05). Conclusion: The patients treated with nebivolol experienced 12-month cardiovascular events at a lower rate than those treated with metoprolol succinate. However, event rates were similar between the carvedilol and the metoprolol succinate groups and between the nebivolol and the carvedilol groups.
Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies
Authors: Cardinali Daniel P. , Hardeland Rüdiger
Published: May 2016

The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease, including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia. MS is associated with low-grade inflammation of the white adipose tissue, which can subsequently lead to insulin resistance, impaired glucose tolerance and diabetes. Adipocytes secrete proinflammatory cytokines as well as leptin and trigger a vicious circle which leads to additional weight gain largely as fat. The imbalance between inflammatory and anti-inflammatory signals is crucial to aging. Healthy aging can benefit from melatonin, a compound known to possess direct and indirect antioxidant properties, to have a significant protective effect on mitochondrial function, to enhance circadian rhythm amplitudes, to modulate the immune system and to exhibit neuroprotective actions. Melatonin levels decrease in the course of senescence and are more strongly reduced in diseases related to insulin resistance. This short review article analyzes the multiple protective actions of melatonin that are relevant to the attenuation of inflammatory responses and progression of inflammaging and how melatonin is effective to curtail MS in animal models of hyperadiposity. The clinical data supporting the possible therapeutic use of melatonin in human MS are also reviewed. Since attention has been focused on the development of potent melatonin analogs with prolonged effects (ramelteon, agomelatine, tasimelteon, piromelatine) and in clinical trials these analogs were administered in doses considerably higher than those usually employed for melatonin, clinical trials on melatonin in the range of 50-100 mg/day are needed to further assess its therapeutic value in MS.
An Overview of Diagnosis of Primary Autoimmune Hypophysitis in a Prospective Single-Center Experience
Authors: Chiloiro Sabrina , Tartaglione Tommaso , Angelini Flavia , Bianchi Antonio , Arena Vincenzo , Giampietro Antonella , Mormando Marilda , Sciandra Mariacarmela , Laino Maria Elena , De Marinis Laura
Published: May 2016

Background: Autoimmune hypophysitis is a rare disease with a natural progression that is not well known. Aim: To collect representative data on clinical features of autoimmune hypophysitis and better characterize the disease. Patients and Methods: A prospective single-center study was designed. Autoimmune hypophysitis-affected patients evaluated from 2011 at our tertiary care Pituitary Unit were enrolled. After ruling out other pituitary masses and secondary causes of hypophysitis, autoimmune hypophysitis was the diagnosis of exclusion. Autoimmune hypophysitis was classified as adenohypophysitis, panhypophysitis, and infundibuloneurohypophysitis according to clinical and neuroradiological findings. Results: A total of 21 patients met the inclusion criteria: 9 were diagnosed with adenohypophysitis, 4 with panhypophysitis, and 8 with infundibuloneurohypophysitis. The frequency of secondary hypoadrenalism was similar in adenohypophysitis, panhypophysitis, and infundibuloneurohypophysitis. Growth hormone deficit and secondary hypogonadism occurred more frequently in infundibuloneurohypophysitis than in adenohypophysitis and panhypophysitis (p = 0.009; p = 0.04). All cases of multiple pituitary secretion deficits occurred in cases of infundibuloneurohypophysitis (p = 0.04). No correlations between hypophysitis subtype and anti-pituitary and anti-hypothalamus autoantibodies were found. A higher frequency of extractable nuclear antigens (ENA) and anti-nuclear antibodies (ANA) was found in cases of panhypophysitis (OR 5.0, 95% CI 0.86-28.8, p < 0.001, and OR 1.8, 95% CI 1.1-3.2, p = 0.02, respectively) as compared to adenohypophysitis and infundibuloneurohypophysitis. Conclusion: Infundibuloneurohypophysitis should be taken into account in the etiological diagnosis of hypopituitarism, particularly if it is associated with diabetes insipidus and in cases of growth hormone deficit, secondary hypogonadism, or multiple hormone deficits. Contrast-enhanced MRI is crucial for the clinical and noninvasive diagnosis of hypophysitis. Screening for autoantibodies, particularly anti-ENA and anti-ANA, is strongly suggested in the clinical context of hypophysitis.
ОСОБЛИВОСТІ АНЕМІЧНОГО СИНДРОМУ ЯК ПРОЯВУ ТРОФОЛОГІЧНОЇ НЕДОСТАТНОСТІ ПРИ ХРОНІЧНОМУ ПАНКРЕАТИТІ НА ТЛІ ІШЕМІЧНОЇ ХВОРОБИ СЕРЦЯ
Authors: Babinets L. S. , Melnyk N. A. , Tsybulska L. S. , Skrypnyk М. V.
Published: May 2016

РЕЗЮМЕ. У роботі представлені особливості анемічного синдрому та зміни трофологічного статусу у хворих
на хронічний панкреатит із супутньою ішемічною хворобою серця, а також досліджено взаємозв’язок між
параметрами трофологічного статусу та показниками анемії у таких хворих.

КЛЮЧОВІ СЛОВА: хронічний панкреатит, ішемічна хвороба серця, анемічний синдром, трофологічна
недостатність.
ДО ПИТАННЯ ПРИЧИН ПІСЛЯОПЕРАЦІЙНОГО РЕЦИДИВУ ВАРИКОЗНОЇ ХВОРОБИ НИЖНІХ КІНЦІВОК
Authors: Hoshchynskyi V. B. , Kochan R. S. , Borys R. M. , Luhovyi O. B.
Published: May 2016

РЕЗЮМЕ. У 65 хворих на варикозну хворобу нижніх кінцівок проведено дослідження маркерів ендотеліальної
дисфункції до операції, в ранньому (10 днів) та пізньому (60 днів) післяопераційному періоді. Встановлено
збільшення показників маркерів ендотеліальної дисфункції як до операції, так і в післяопераційному періоді.
Морфологічне дослідження глибоких вен нижніх кінцівок дозволило констатувати, що причиною ендотеліальної
дисфункції можуть бути суттєві зміни у структурі всіх шарів стінки вени, особливо ендотеліального шару.

Ключові слова : варикозна хвороба, ендотеліальна дисфункція, морфологічні дослідження.
ОБҐРУНТУВАННЯ МЕХАНІЗМУ ДІЇ НАНООКСИДІВ МЕТАЛІВ НА ПАТОГЕННУ ФЛОРУ ГНІЙНИХ РАН
Authors: Popadyuk O. Ya. , Melnyk D. O.
Published: May 2016

РЕЗЮМЕ. Проблема лікування гнійних ран залишається актуальною до теперішнього часу. Неправильне
застосування антибіотиків та неефективне лікування змушує проводити пошук, вивчення та впровадження
нових протимікробних засобів боротьби з інфекцією у рані. На сьогодні все частіше з'являються повідомлення
про високу антибактеріальну ефективність нанорозмірних оксидів металів. На жаль, не до кінця зрозумілим є
механізм дії нанооксиду цинку на бактеріальну клітину. Метою нашої роботи було обґрунтування дії нанооксиду
цинку на бактерію за допомогою квантово-хімічних розрахунків. Для проведення розрахунків структурних та
енергетичних параметрів досліджуваних систем застосували напівемпіричний метод PM3. В результаті проведених
квантохімічних розрахунків обґрунтовано антибактеріальну дію нанооксидів, зокрема нанооксиду цину, де
енергетично вигідне відщеплення радикалу кисню від поверхні нанооксиду цинку приводить до проведення
низки радикальних реакцій з утворенням пероксидів та подальшим руйнуванням бактерій.

КЛЮЧОВІ СЛОВА: нанооксиди, нанооксид цинку, нанооксид магнію, патогенна флора, механізм дії, квантово-
хімічні розрахунки.
ВПЛИВ КОМПЛЕКСНОЇ ТЕРАПІЇ НА ПОКАЗНИКИ ІНДЕКСНОЇ ОЦІНКИ СТАНУ ТКАНИН ПАРОДОНТА
Authors: Sydliaruk N. I. , Mysula I. R.
Published: May 2016

РЕЗЮМЕ. Актуальною проблемою стоматології на сьогодні є захворювання слизової оболонки порожнини
рота. Проведені дослідження свідчать, що при захворюваннях шлунково-кишкового тракту виникають різноманітні
запальні та дистрофічні зміни у СОПР, що є наслідком морфофункціональної та нервово-рефлекторної єдності
всього травного каналу.
Метою нашого дослідження було дослідити стан тканин пародонта до та після комплексного лікування з
використанням індексів PMA та CPITN в поєднанні з вивченням біохімічних показників сироватки крові.
У всіх груп пацієнтів згідно з індексною оцінкою стану тканин пародонта рівень ЦІК, ЕІ, МДА, ДК був
підвищеним, а система АОЗ розбалансована, що свідчило про наявність у хворих ушкоджень тканин. При цьому
більш значні зміни показників, а значить і більш значні ушкодження тканин були у хворих з середнім та тяжким
ступенями запальних явищ у СОПР та у пацієнтів, які «потребували курсу професійної гігієни», кому «показана
місцева протизапальна терапія» і у тих, кому «показане комплексне лікування».
Застосування комплексної терапії дало найкращий позитивний ефект у тих хворих, у яких пародонтальний
статус за індексом CPITN відповідав рівню «слід покращити гігієну» та «потребує курсу професійної гігієни».
Показники сироватки крові у них фактично не відрізнялися від показників групи пацієнтів, які «лікування не
потребують».

КЛЮЧОВІ СЛОВА: ушкодження слизової оболонки порожнини рота, гастродуоденіт, пародонтальні індекси,
біохімічні показники, сироватка крові.
ОСОБЛИВОСТІ МЕТАБОЛІЗМУ СПОЛУЧНОЇ ТКАНИНИ ТА ПРОЗАПАЛЬНИХ ЦИТОКІНІВ У ПАЦІЄНТІВ З ОСТЕОАРТРОЗОМ ТА КОМОРБІДНИМИ ГІПЕРТОНІЧНОЮ ХВОРОБОЮ ТА ОЖИРІННЯМ
Authors: Khukhlina O. S. , Tanas O. V.
Published: May 2016

РЕЗЮМЕ. У статті викладено результати дослідження показників обміну сполучної тканини та прозапальних
цитокінів у хворих на остеоартроз з коморбідними есенціальною артеріальною гіпертензією та ожирінням.
Встановлено, що перебіг остеоартрозу супроводжується підвищенням активності системного запалення,
інтенсивність якого за наявності супутніх гіпертонічної хвороби та ожиріння вірогідно зростає. У хворих на
остеоартроз вміст прозапальних цитокінів у крові є вірогідно підвищеним і зростає із приєднанням ожиріння.

КЛЮЧОВІ СЛОВА: остеоартроз, артеріальна гіпертензія, ожиріння, сполучна тканини, цитокіни.
ФУНКЦІОНАЛЬНИЙ СТАН ПЕЧІНКИ У ХВОРИХ ІЗ КОМОРБІДНИМ ПЕРЕБІГОМ ОСТЕОАРТРОЗУ ТА ОЖИРІННЯ ЗАЛЕЖНО ВІД ПРИЗНАЧЕНОГО НЕСТЕРОЇДНОГО ПРОТИЗАПАЛЬНОГО ПРЕПАРАТУ
Authors: Khukhlina О. S. , Liakhovych О. D. , Kaniovska L. V. , Voyevidka O. S.
Published: May 2016

РЕЗЮМЕ. З метою з’ясування особливостей ураження печінки у хворих на остеоартроз та ожиріння на тлі
призначення нестероїдних протизапальних засобів (НСПЗ) (німесулід, мелоксикам, диклофенак, парацетамол,
ібупрофен) обстежено 48 пацієнтів з ОА колінних та кульшових суглобів із ожирінням І–ІІІ ступенів. Встановлено,
що максимальний гепатотоксичний вплив при призначенні упродовж 2 тижнів хворим на ОА на тлі ожиріння
мали парацетамол, диклофенак, німесулід, ібупрофен, а мінімальний – мелоксикам, який є рекомендованим до
призначення за даної форми коморбідності.

КЛЮЧОВІ СЛОВА: остеоартроз, ожиріння, НПЗП.
ЕФЕКТИВНІСТЬ КОМПЛЕКСНОГО ЛІКУВАННЯ ХВОРИХ З ПОПЕРЕКОВИМ ОСТЕОХОНДРОЗОМ ЗА ДИНАМІКОЮ СТАНУ ЕНДОТЕЛІАЛЬНОЇ ДИСФУНКЦІЇ
Authors: Babinets L. S. , Nadkevych A. L. , Hotʹ I. V.
Published: May 2016

На сьогодні не вирішені численні питання етіопатогенезу, діагностики та лікування поперекового остеохондрозу (ПОХ). Зокрема, роль системи оксиду азоту (NO) у розвитку і прогресуванні ПОХ та остеодефіциту (ОД) залишається недостатньо з’ясованою.
ПОКАЗНИКИ ОКИСНОГО ГОМЕОСТАЗУ ТА ВМІСТ ОКСИДУ АЗОТУ КРОВІ У ХВОРИХ НА ГІПЕРТОНІЧНУ ХВОРОБУ В ПОЄДНАННІ З ІШЕМІЧНОЮ ХВОРОБОЮ СЕРЦЯ І ЦУКРОВИМ ДІАБЕТОМ ТИПУ 2
Authors: Boyko V. V.
Published: May 2016

Метою дослідження було вивчити стан оксидантно-антиоксидантної системи, вміст кінцевих продуктів монооксиду нітрогену (NO) крові у хворих на гіпертонічну хворобу (ГХ) ІІ стадії та в поєднанні з ішемічною хворобою серця (ІХС) і цукровим діабетом (ЦД) типу 2.
КЛІНІЧНІ ПРОЯВИ ВЕГЕТАТИВНОГО ДИСБАЛАНСУ У КЛІМАКТЕРИЧНОМУ ПЕРІОДІ ТА МОЖЛИВОСТІ ЇХ КОРЕКЦІЇ
Authors: Zhdan V. M. , Katerenchuk I. P.
Published: May 2016

Актуальність проблеми. Вегетативні порушення, які виявляють майже у 80 % жінок, є найбільш ранніми проявами клімактеричного синдрому.
Кардіальна і церебральна симптоматика значно погіршує якість життя і є передумовою тяжких ускладнень, які погіршують якість життя
та зменшують його тривалість.
РОЛЬ АДИПОКІНІВ ЖИРОВОЇ ТКАНИНИ У ПРОГРЕСУВАННІ БРОНХІАЛЬНОЇ АСТМИ У ХВОРИХ З ОЖИРІННЯМ
Authors: Pasiyeshvili L. M. , Pasiyeshvili T. M.
Published: May 2016

Вступ. Бронхіальна астма (БА) належить до
хронічних рецидивуючих захворювань внутрішніх
органів, що має спадкову схильність, тобто її фор-
мування та перебіг є генетично зумовленим. Поєд-
нання БА з іншими неінфекційними захворюван-
нями внутрішніх органів доволі часто обумовлює
тяжкий перебіг, що проявляється формуванням
рефрактерних до загальновизнаної терапії форм.
До захворювань, вплив яких може призвести до
розвитку ускладнень, належить ожиріння.
На теперішній час ожиріння розглядають у
контексті самостійної хвороби з метаболічними
наслідками, а жирову тканину – як ендокринний
орган, що продукує багато активних речовин. При-
єднання ожиріння у хворих на БА в такому разі до-
дає не тільки механічних перешкод, які виникають
внаслідок зменшення екскурсії діафрагми та на-
вантаження загальною масою тіла, але й сприяє
накопиченню в організмі адипокінів (ІЛ-1, ФНП-α,
лептину, резистину, апеліну тощо), які можуть під-
тримувати запальний процес у бронхолегеневій
системі. Тобто можна припустити, що загострен-
ня БА у хворих з ожирінням не завжди пов’язане
з несприятливими позалегеневими умовами (ін-
фекційні агенти), а її перебіг, формування тяжких
форм та ускладнень може бути результатом ендо-
кринної активності жирової тканини.
ДО ПИТАННЯ ОПТИМІЗАЦІЇ ПЕРВИННОЇ ЛАНКИ СИСТЕМИ ОХОРОНИ ЗДОРОВ’Я
Authors: Smirnova L. V. , Panchishin N. Ya. , Terenda N. O. , Halytsʹka-Kharkhalis O. Ya. , Litvinova O. N. , Petrashik Yu. M.
Published: May 2016

Складові моделі реформування пер-

винної медичної допомоги (ПМД) полягають у

юридичному та фінансово-економічному роз-

межуванні первинної допомоги та медичної до-

помоги інших рівнів. Надання ПМД мають забез-

печувати центри ПМД, а також лікарі загальної

практики – сімейні лікарі.

Передбачене реформами зміщення уваги зі

спеціалізованої на первинну медичну допомогу

потребує підготовки лікарів загальної практики

або сімейних лікарів, які б надавали більшу кіль-

кість базових послуг, проводили профілактику,

ранню діагностику та координували лікування па-

цієнтів. Підготовку таких спеціалістів розпочали

одночасно двома способами: реформування ме-

дичної освіти в медичних вишах та перепідготов-

ка практикуючих терапевтів, педіатрів та інших

спеціалістів.
Вплив захворювань щитоподібної залози на стоматологічний статус людини (огляд літератури)
Authors: Chorniy A. V. , Shmanko V. V.
Published: May 2016

The article adduces the problem of influence of thyroid disease on dental human health. Attention is paid to spread and character of pathological processes in periodontal prevalence of caries and non-carious lesions in patients with thyroid dysfunction. 
Modelos em geografia física: conceitos e aplicações na previsão de escorregamentos
Authors: Vieira Bianca Carvalho , Martins Tiago D.
Published: May 2016

Os diferentes tipos de modelos têm uma relação direta com o grau de abstração da realidade, ocorrendo desde formas mais simples, concretas e específicas, em que a realidade é transformada apenas em nível de escala até a elaboração de modelos conceituais pela aplicação de formulações matemáticos. Dentre esses, os de base física, que descrevem fisicamente os processos por meio de equações, desconsiderando a subjetividade, têm sido adotados, por exemplo, em estudos de movimento de massa. Assim, esse trabalho objetiva discutir brevemente a fundamentação dos conceitos de modelos utilizados na Geografia Física, destacando dois modelos aplicados em estudos relacionados a escorregamentos e que demostraram resultados positivos em seus testes. Primeiramente foi discutido o modelo clássico de correlação entre a pluviosidade e a ocorrência de escorregamentos. Já o segundo modelo apresentado, o modelo matemático em base física, SHALSTAB, avalia a suscetibilidade de ocorrência de escorregamentos rasos. Por fim são apresentados exemplos de resultados desses modelos aplicados no Brasil.
A produção da cidade olímpica e os sinais da crise de um modelo globalitário
Authors: Mascarenhas Gilmar
Published: May 2016

Nas últimas três ou quatro décadas, o urbanismo olímpico se converteu em caros projetos de grande vulto, com impactos de alta visibilidade sobre questões sociais e ambientais em cada cidade-sede. No entanto, nos últimos cinco anos mostram uma crescente consciência global contra o alto investimento público nesses eventos, a violência dos despejos em massa de pobres sob interesses de gentrificação e a produção dos chamados “elefantes brancos”. O sistema olímpico tem percebido a crise e decidiu alterar suas regras "globalitárias", através da Agenda 2020. O nosso objetivo é examinar este novo cenário de transição global e verificar como Rio de Janeiro 2016 pode ser a última edição deste urbanismo olímpico contestado.
Reflexões sobre a geografia
Authors: Dresch Jean
Published: May 2016

A Geografia é uma ciência – pouco importa para o momento o sentido que se atribua ao termo – a um tempo bastante antiga e muito recente.Desde a Antiguidade, os pesquisadores adotaram o método de descrever e, em menor grau, de explicar, a ocorrência dos fenômenos físicos e humanos na superfície da Terra, cuja distribuição de influências recíprocas forma um todo bastante complexo.
Arco Tietê: um território estratégico nos contornos entre o Estado e o mercado
Authors: Silva Fernanda Pinheiro
Published: May 2016

Ao analisar o espaço concebido como política de Estado, pode-se desvelar tendências importantes do processo de urbanização. Trata-se de uma forma possível de abordar projetos urbanísticos específicos, servindo de base para compreender como e porque determinados fragmentos do urbano tornam-se alvos estratégicos da política do espaço e o que isto significa em termos da reprodução das relações (sociais) de produção. Inicia-se, a partir desta ressalva, uma tentativa de problematizar a criação e lançamento do território estratégico Arco Tietê como momento da reprodução crítica do capital, buscando sempre suas relações com a urbanização, também crítica, da cidade de São Paulo.
Entre a metrópole e a cidade média: a complexidade das interações espaciais e das dinâmicas de centralidade da cidade de Castanhal no nordeste paraense
Authors: Ribeiro Willame De Oliveira
Published: May 2016

A cidade de Castanhal, nordeste do Pará, possui papéis de grande complexidade na rede urbana regional, pois se situa na intermediação entre a realidade metropolitana e a centralidade de cidade média exercida no nordeste paraense. Diante disso, esse trabalho busca refletir sobre a seguinte questão: Quais os papéis desempenhados pela cidade de Castanhal na região nordeste do Estado do Pará diante do processo de dispersão metropolitana de Belém? A partir da construção de referencial teórico, de levantamentos documentais e de levantamentos em campo se constatou que a complexidade das interações espaciais é uma das principais marcas de Castanhal, que se constitui enquanto uma cidade híbrida, possuindo uma dimensão metropolitana e uma dimensão de cidade média.
Lugares de la memoria, lugares de la ausencia en la poesía de Fabio Morábito
Authors: Fernandez Adechedera Fabiola
Published: May 2016

Este artículo propone un análisis de la poesía de Fabio Morábito (1955 - ) a partir de ciertos aspectos autobiográficos en ella presentes. La biografía del autor lo sitúa en medio de una dislocación geográfica y lingüística entre Egipto, Italia y México. De esa forma, analizo algunos de los poemas donde es posible identificar la presencia de una memoria personal que alude a pasajes específicos de la infancia en Milán y la mudanza a la Ciudad de México. Los mismos asientan los rasgos de una identidad discursiva signada por el desarraigo, la mudanza y la pérdida, temas fundamentales de su poesía.
Vivir, escribir, enfermar. Sobre exilio y enfermedad en Antes que anochezca de Reynaldo Arenas
Authors: León Denise
Published: May 2016

En su ensayo sobre literatura y enfermedad, Roberto Bolaño construye una tríada íntima de experiencia que nos guía a través de las motivaciones fundamentales que hay detrás de toda poesía y que está constituida ciertamente por los viajes, el sexo y los libros. Me propongo indagar en el presente trabajo cómo funciona esta tríada en la obra del cubano Reynaldo Arenas, especialmente en su autobiografía, Antes que anochezca, donde la enfermedad re direcciona la trayectoria del viaje. Si la fuga funciona como una constante que tensiona la obra y la vida de Arenas, en su autobiografía exilio y enfermedad se fusionan como signos intercambiables.