bluuebunny/crossref_metadata_2025 huggingface dataset:
Large overlap in neutrophil transcriptome between lupus and COVID-19 with limited lupus-specific gene expression
Authors: Najjar Rayan , Rogel Noga , Pineda Jose Mario Bello , Wang Xiaoxing , Tran Megan , Bays Alison , Mustelin Tomas
Published: February 2024

Objectives

To illuminate the poorly understood aetiology of SLE by comparing the gene expression profile of SLE neutrophils with that of neutrophils from patients infected by SARS-CoV-2, a disease (COVID-19) with well-defined antigens and a similar type I interferon response.

Methods

RNA sequencing of neutrophils from patients with SLE (n=15) and healthy controls (n=12) was analysed for differential gene expression and modulated pathways. The same analyses were performed on a similar neutrophil dataset from patients with SARS-CoV-2 infection (n=30) and healthy controls (n=8). Next, we carried out comparative analyses to identify common and unique transcriptional changes between the two disease contexts, emphasising genes regulated in opposite directions.

Results

We identified 372 differentially expressed genes in SLE neutrophils compared with healthy donor neutrophils (≥2 fold, p<0.05), 181 of which were concordant with transcriptional changes in SARS-CoV-2-infected individuals compared with their respective healthy controls. In contrast, 118 genes demonstrated statistically significant alterations exclusive to SLE, including 28 genes that were differentially expressed in opposite directions in the two diseases.

Conclusions

The substantial overlap between neutrophil responses in SLE and COVID-19 suggests that the unknown cause of SLE is functionally similar to a viral infection and drives a similar immune activation and type I interferon response. Conversely, the genes regulated in the opposite direction represent responses unique to SLE. These include tyrosylprotein sulfotransferase-1 and nucleic acid deaminases of the APOBEC family, which can catalyse cytosine-to-uridine editing of both RNA and DNA, and other RNA-modifying enzymes.
Initiation patterns of anticoagulants for atrial fibrillation among older UK adults with and without chronic kidney disease, 2010–2020
Authors: Liaw Julia , Liaw Deborah , Dave Chintan
Published: February 2024

Background

There is a paucity of data on the initiation patterns of anticoagulants among older atrial fibrillation patients with and without chronic kidney disease (CKD).

Setting and methods

We used the UK Clinical Practice Research Datalink (2010–2020) to conduct a retrospective cohort study to evaluate anticoagulant initiation patterns for older adults (≥65 years) with CKD (N=18 421) and without CKD (N=41 901), categorised by severity of CKD: stages 3a, 3b and 4, and initiation dose by respective direct oral anticoagulant (DOAC).

Results

Over the study period, warfarin initiations sharply declined and were replaced by DOACs regardless of CKD status or stage. By 2020, patients with CKD were modestly more likely (8.8% difference) to initiate apixaban compared with those without CKD (58.8% vs 50.0%; p<0.01). Among patients with CKD, those with stages 3a and 3b CKD had higher apixaban initiations compared with stage 4 CKD (56.9% and 64.6% vs 52.9%, respectively; p<0.01). Conversely, patients with stage 4 CKD were over three times more likely to initiate warfarin (14.7%) compared with those with stage 3a (2.6%) and 3b (4.0%) CKD (p<0.01). Throughout the study period, there was a rise in the proportion of patients initiating the higher 10 mg daily dose for apixaban, with an increase of 20.6% (from 64.3% in 2013 to 84.9% in 2020; p value for trend <0.01) among patients without CKD, and 21.8% (53.1% to 74.9%; p<0.01), 24.4% (18.8% to 43.2%; p<0.01) and 18.5% (0.0% to 18.2%; p<0.01) among patients with stages 3a, 3b and 4 CKD, respectively.

Conclusions and relevance

Initiation of DOACs increased regardless of CKD status and stage, although with a reduced magnitude in severe CKD. Apixaban emerged as the preferred agent, with a secular trend towards the higher initiation dose in all subgroups. These findings illuminate evolving trends and priorities in anticoagulant preferences among patients with and without CKD.
Design and Development of Intelligent Learning System for University Innovation and Entrepreneurship Based on Knowledge Visualisation
Authors: Feng Bibo
Published: February 2024

To build a comprehensive learning resource system covering learning process, learning users, learning resources and other aspects, an intelligent learning system for innovation and entrepreneurship in universities was constructed and designed combined with knowledge visualisation theory. The system includes student information record module, system recommendation calculation module, learning material module, and knowledge visualisation module. The research focuses on the system recommendation calculation module, including the User-based Collaborative Filtering Algorithm (UCF) and the Joint Recommendation (JR) algorithm of the application content recommendation algorithm. The best neighbour number of JR is 20, and the best transmission path length is 2. The recommendation effect is optimal under this setting. The convergence iterations of the training and test set of the joint recommendation algorithm are 80 times and 100 times, respectively. For the training set and test set, the accuracy, precision, sensitivity, recall, running time, error, and other performance evaluation indicators of the joint recommendation algorithm are better than the corresponding values of other recommendation algorithms. The system has a good design effect and experience effect in the application of the online learning platform.
From Geospatial to Spatial -Omics
Authors: Moses Lambda
Published: February 2024

When Los Angeles is mentioned, cycling is usually not the first thing that comes to mind. However, during my past 10 years in LA studying molecular biology and bioinformatics, my bike trips through the geographical space of LA have inspired many ideas in my research in spatial data analysis in bioinformatics. I have written software to bring decades of research in geospatial data analysis to spatial -omics, as my trips make me ponder on spatial phenomena in general.
Temporal Implicit Multimodal Networks for Investment and Risk Management
Authors: Ang Gary , Lim Ee-Peng
Published: February 2024

Many deep learning works on financial time-series forecasting focus on predicting future prices/returns of individual assets with numerical price-related information for trading, and hence propose models designed for univariate, single-task, and/or unimodal settings. Forecasting for investment and risk management involves multiple tasks in multivariate settings: forecasts of expected returns and risks of assets in portfolios, and correlations between these assets. As different sources/types of time-series influence future returns, risks, and correlations of assets in different ways, it is also important to capture time-series from different modalities. Hence, this article addresses financial time-series forecasting for investment and risk management in a multivariate, multitask, and multimodal setting. Financial time-series forecasting, however, is challenging due to the low signal-to-noise ratios typical in financial time-series, and as intra-series and inter-series relationships of assets evolve across time. To address these challenges, our proposed Temporal Implicit Multimodal Network (TIME) model learns implicit inter-series relationship networks between assets from multimodal financial time-series at multiple time-steps adaptively. TIME then uses dynamic network and temporal encoding modules to jointly capture such evolving relationships, multimodal financial time-series, and temporal representations. Our experiments show that TIME outperforms other state-of-the-art models on multiple forecasting tasks and investment and risk management applications.
Overcoming Diverse Undesired Effects in Recommender Systems: A Deontological Approach
Authors: G. Duran Paula , Gilabert Pere , Seguí Santi , Vitrià Jordi
Published: February 2024

In today’s digital landscape, recommender systems have gained ubiquity as a means of directing users toward personalized products, services, and content. However, despite their widespread adoption and a long track of research, these systems are not immune to shortcomings. A significant challenge faced by recommender systems is the presence of biases, which produces various undesirable effects, prominently the popularity bias. This bias hampers the diversity of recommended items, thus restricting users’ exposure to less popular or niche content. Furthermore, this issue is compounded when multiple stakeholders are considered, requiring the balance of multiple, potentially conflicting objectives.

In this article, we present a new approach to address a wide range of undesired consequences in recommender systems that involve various stakeholders. Instead of adopting a consequentialist perspective that aims to mitigate the repercussions of a recommendation policy, we propose a deontological approach centered around a minimal set of ethical principles. More precisely, we introduce two distinct principles aimed at avoiding overconfidence in predictions and accurately modeling the genuine interests of users. The proposed approach circumvents the need for defining a multi-objective system, which has been identified as one of the main limitations when developing complex recommenders. Through extensive experimentation, we show the efficacy of our approach in mitigating the adverse impact of the recommender from both user and item perspectives, ultimately enhancing various beyond accuracy metrics. This study underscores the significance of responsible and equitable recommendations and proposes a strategy that can be easily deployed in real-world scenarios.
Low-Intensity Wildfire Alters Selected Soil Properties in the Tropical Shorea robusta Forest
Authors: Dhungana Badri Prasad , Thapa Chhetri Vivek , Baniya Chitra Bahadur , Sharma Sundar Prasad
Published: February 2024

Wildfires may impact specific soil properties differently, including positive, negative, or neutral effects. However, due to the absence of uniformity in comprehending how wildfires influence soil nutrients, this research endeavors to scrutinize the particular effect of wildfire on selected soil properties in the tropical Shorea robusta forest. We analyzed 42 soil samples obtained from the topsoil of 0–10 cm comprising 21 samples from the fire-affected area and 21 from the fire-unaffected area. The physicochemical parameters of the soil including soil pH, soil organic carbon (SOC), total nitrogen (TN), available phosphorus, and available potassium were examined and compared in two sites. The impact of fire was statistically tested after comparing each variable between the two sites. Using the Mann–Whitney U test and the Pearson correlation coefficient, we analyzed the data. The results indicated that the average chemical parameters of the soil except for pH in the fire-affected area (pH = 5.43, SOC = 1.6%, TN = 0.1%, and P=246.85 kg·ha−1) were greater than those in the fire-unaffected area (pH = 5.71, SOC = 1.21%, TN = 0.09%, and P=174.21 kg·ha−1). There were statistically significant differences in the soil parameters, including pH, SOC, TN, and P, but not with K. The soil pH was reduced in the fire-affected area, with a significant positive correlation with SOC, TN, and K. Overall, the low-intensity wildfire facilitated the proliferation of soil chemical properties in the tropical S. robusta forest. Hence, low-intensity wildfire could be a suitable forest management strategy to alter soil nutrient status. Additionally, these findings can aid in enhancing forest fire management strategies for effectively managing the tropical S. robusta forest.
Vanadium Redox Flow Battery Using an N‐Doped Porous Carbon‐Coated Positive Electrode Derived from Zeolitic Imidazolate Framework‐8‐Coated Graphite Felt
Authors: Kim Ju Yeong , Kang Min Gu , Kang Yun Chan , Ahn Wook , Song Shin Ae , Kim Kiyoung , Woo Ju Young , Lee Sang Ho , Lim Sung Nam
Published: February 2024

The poor electrochemical activity and low wettability of graphite felt (GF) electrodes significantly limit the energy efficiency and power of vanadium redox flow batteries (VRFBs). To solve these problems, we developed an N‐doped porous carbon‐coated electrode by the carbonization of zeolitic imidazolate framework‐8‐ (ZIF‐8‐) coated GF. By controlling the carbonization temperature, the effects of temperature on the structural morphology, pore structure, and amount and type of functional groups of the electrode were confirmed. In addition, the effect of the change in the pore structure and the amount and type of functional groups on the electrocatalytic activity for the vanadium redox reaction was demonstrated. The synthesized N‐doped porous carbon‐coated electrode, which showed the best electrochemical activity, had a sufficient amount of nitrogen functional groups with a high ratio of graphitic N and the highest surface area and pore volume among all the samples, providing abundant active sites for the VO2+/VO2+ redox reaction. The VRFB fabricated using prepared electrode exhibited energy and voltage efficiencies of 70.44% and 73.44%, respectively, at 200 mA cm-2, which were 11.77% and 11.08% higher than those of the bare GF electrode. Furthermore, the modified battery operated effectively at a high current density of 350 mA cm-2. The energy efficiency exhibited excellent stability over 500 charge/discharge cycles at 250 mA cm-2. Hence, this study presents a promising method for the development of high‐performance VRFB electrodes.
Parsing of Research Documents into XML Using Formal Grammars
Authors: Iwashokun Opeoluwa , Ade-Ibijola Abejide
Published: February 2024

Automatic information extraction of content and style format in paged documents is challenging. It requires the conversion of the original document into a granular level of details for which every document section and content is identifiable. This functionality or tool does not exist for any academic research document yet. In this paper, we present an automated process of parsing research paper documents into XML files using a formal method approach of context‐free grammars (CFGs) and regular expressions (REGEXs) definable of a standard template. We created a tool for the algorithms to parse these documents into tree‐like structures organized as XML files named research_XML (RX) parser. The RX tool performed the extraction of syntactic structure and semantic information of the document’s contents into XML files. These XML output files are lightweight, analyzable, query‐able, and web interoperable. The RX tool has a success rate of 91% when evaluated on fifty varying research documents of 160 average pages and 8,004 total pages. The tool and test data are accessible on GitHub repo. The novelty of our process is specific to applying formal techniques for information extraction in structured multipaged documents and academic research documents thus advancing the research in automatic information extraction.
Oxidative Polymerization of Aniline on the Surface of Sisal Fibers (SFs) as Defluoridation Media for Groundwater
Authors: Teklu Tesfamariam
Published: February 2024

Chemical modification of sisal fibers via in situ oxidative polymerization of aniline was conducted to examine their defluoridation capacity for fluoride from drinking water. The effects of polyaniline modifications have shown significant changes on the chemical moieties and defluoridation capacity of sisal fibers (SFs). FTIR peaks at 1440 cm−1 and 1560 cm−1 revealed the presence of benzoid and quinoid structures together with sisal fiber (SF). Thermal profiles confirmed the enhancement of thermal stability of polyaniline-modified sisal fibers (PAniMSFs). SEM microstructure also proved the surface roughening of SFs as a result of polyaniline modifications. Optimal batch adsorption parameters (pH, contact time, adsorbent dose, and initial concentration) were found to be 5, 60 min, 1 g, and 10 mg/L, respectively. Adsorption kinetics proved that the removal of fluoride follows pseudo-second-order model (K2 = 0.18 g. (mg·min)−1), while the adsorption isotherm well described by the Langmuir and Freundlich model with an experimental adsorption capacity of 2.49 mg/g. Hence, modifications and improvements are required to reduce the amount of fluoride to a permissible level and enhance the longevity and activity of adsorbent materials.
Pharmacological Manipulation of Corticotropin-Releasing Factor Receptors in the Anterior and Posterior Subregions of the Insular Cortex Differently Affects Anxiety-Like Behaviors in the Elevated Plus Maze in Rats
Authors: Lopes Lucas M. , Reis-Silva Lilian L. , Rodrigues Bruno , Crestani Carlos C.
Published: February 2024

Neuroimaging data in humans and neurobiological studies in rodents have suggested an involvement of the insular cortex (IC) in anxiety manifestations. However, the local neurochemical mechanisms involved are still poorly understood. Corticotropin-releasing factor (CRF) neurotransmission has been described as a prominent neurochemical mechanism involved in the expression of anxiety-like behaviors, but the brain sites related are poorly understood. Additionally, several findings indicate that control of physiological and behavioral responses by the IC occurs in a site-specific manner along its rostrocaudal axis. Thus, this study is aimed at evaluating the effect of CRF receptor agonism and antagonism within the anterior and posterior subregions of the IC in controlling anxiety-related behaviors in the elevated plus maze (EPM). For this, independent groups (six groups) of animals received bilateral microinjections of vehicle, the selective CRF1 receptor antagonist CP376395, or CRF into either the anterior or posterior subregions of the IC. Ten minutes later, the behavior in the EPM was evaluated for five minutes. Treatment of the anterior IC with CP376395, but not with CRF, increased the time and number of entries into the open arms of the EPM. CRF, but not the CRF1 receptor antagonist, microinjected into the posterior IC also increased exploration of the EPM open arms. Taken together, these data indicate that CRFergic neurotransmission in the anterior IC is involved in the expression of anxiety-related behaviors in the EPM. This neurochemical mechanism does not seem to be activated within the posterior IC during exposure to the EPM, but the effects caused by CRF microinjection indicate that activation of CRF receptors in this IC subregion might evoke anxiolytic-like effects.
Supplementary Table S6 from Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells
Authors: Xia Li , Liu Jie-Yang , Yang Meng-Ying , Zhang Xue-Hong , Jiang Yue , Yin Qian-Qian , Luo Chen-Hui , Liu Hong-Chen , Kang Zhi-Jie , Zhang Cheng-Tao , Gao Bei-Bei , Zhou Ai-Wu , Cai Hai-Yan , Waller Edmund K. , Yan Jin-Song , Lu Ying
Published: February 2024

General characteristics of AML or CML patient samples used in the experiments.
Supplementary Table S5 from Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells
Authors: Xia Li , Liu Jie-Yang , Yang Meng-Ying , Zhang Xue-Hong , Jiang Yue , Yin Qian-Qian , Luo Chen-Hui , Liu Hong-Chen , Kang Zhi-Jie , Zhang Cheng-Tao , Gao Bei-Bei , Zhou Ai-Wu , Cai Hai-Yan , Waller Edmund K. , Yan Jin-Song , Lu Ying
Published: February 2024

Characteristics of the two patient treated with osimertinib.
Supplementary Data from Targeting Tumor Heterogeneity with Neoantigen-Based Cancer Vaccines
Authors: Pounraj Saranya , Chen Shuxiong , Ma Linlin , Mazzieri Roberta , Dolcetti Riccardo , Rehm Bernd H.A.
Published: February 2024

Supplementary Table 2
Table 2 from Deep Learning Enables Spatial Mapping of the Mosaic Microenvironment of Myeloma Bone Marrow Trephine Biopsies
Authors: Hagos Yeman Brhane , Lecat Catherine S.Y. , Patel Dominic , Mikolajczak Anna , Castillo Simon P. , Lyon Emma J. , Foster Kane , Tran Thien-An , Lee Lydia S.H. , Rodriguez-Justo Manuel , Yong Kwee L. , Yuan Yinyin
Published: February 2024

Patient characteristics: paired diagnostic and posttreatment samples.
Figure 5 from Deep Learning Enables Spatial Mapping of the Mosaic Microenvironment of Myeloma Bone Marrow Trephine Biopsies
Authors: Hagos Yeman Brhane , Lecat Catherine S.Y. , Patel Dominic , Mikolajczak Anna , Castillo Simon P. , Lyon Emma J. , Foster Kane , Tran Thien-An , Lee Lydia S.H. , Rodriguez-Justo Manuel , Yong Kwee L. , Yuan Yinyin
Published: February 2024

Density of immune T cells and plasma cells in MGUS, NDMM, and posttreatment samples. A–G, Box plots showing the difference in density of FOXP3+CD4+ (A), the density of CD8+ (B), the density of FOXP3−CD4+ (C), FOXP3+CD4+:FOXP3−CD4+ ratio (D), FOXP3+CD4+:CD8+ ratio (E), density of BLIMP1+ (F), and CD8+:BLIMP1+ ratio (G) between paired NDMM samples and posttreatment samples (n = 10 pairs). H–J, Box plot showing the difference in density of FOXP3+CD4+(H), the density of BLIMP1+ cells (I), and CD8+:BLIMP1+ cells (J) between MGUS and NDMM samples (n = 19). K and L, Sample images showing the reduction of the density of FOXP3+CD4+ and CD8+ cells (K) and BLIMP1+ cells (L) at posttreatment compared with paired NDMM samples. The cell density is presented per 1 mm2 tissue area.
Supplementary Figure 4 from A Multiethnic Germline–Somatic Association Database Deciphers Multilayered and Interconnected Genetic Mutations in Cancer
Authors: Xin Junyi , Mo Zongchao , Chai Ruichao , Hua Wei , Wang Jiguang
Published: February 2024

Supplementary Figure 4. Annotation of genome-wide significant SNPs associated with somatic alterations (P ≤ 5E-06).
Supplementary Table S2 from PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis
Authors: Xu Xiaonan , Bok Ilah , Jasani Neel , Wang Kaizhen , Chadourne Manon , Mecozzi Nicol , Deng Ou , Welsh Eric A. , Kinose Fumi , Rix Uwe , Karreth Florian A.
Published: February 2024

Supplementary Table S2
Supplementary Data from Osteoclast Cancer Cell Metabolic Cross-talk Confers PARP Inhibitor Resistance in Bone Metastatic Breast Cancer
Authors: Fan Huijuan , Xu Zhanao , Yao Ke , Zheng Bingxin , Zhang Yuan , Wang Xuxiang , Zhang Tengjiang , Li Xuan , Hu Haitian , Yue Bin , Hu Zeping , Zheng Hanqiu
Published: February 2024

Supplemental Figures 1-7
Supplementary Data from SUMOylation-Driven mRNA Circularization Enhances Translation and Promotes Lymphatic Metastasis of Bladder Cancer
Authors: Zhao Yue , Chen Jiancheng , Zheng Hanhao , Luo Yuming , An Mingjie , Lin Yan , Pang Mingrui , Li Yuanlong , Kong Yao , He Wang , Lin Tianxin , Chen Changhao
Published: February 2024

Table S1-S5 and Supplemental methods.
Supplementary Data from SUMOylation-Driven mRNA Circularization Enhances Translation and Promotes Lymphatic Metastasis of Bladder Cancer
Authors: Zhao Yue , Chen Jiancheng , Zheng Hanhao , Luo Yuming , An Mingjie , Lin Yan , Pang Mingrui , Li Yuanlong , Kong Yao , He Wang , Lin Tianxin , Chen Changhao
Published: February 2024

Figure S1
Supplementary Data from SUMOylation-Driven mRNA Circularization Enhances Translation and Promotes Lymphatic Metastasis of Bladder Cancer
Authors: Zhao Yue , Chen Jiancheng , Zheng Hanhao , Luo Yuming , An Mingjie , Lin Yan , Pang Mingrui , Li Yuanlong , Kong Yao , He Wang , Lin Tianxin , Chen Changhao
Published: February 2024

Figure S3
Supplementary Data from SUMOylation-Driven mRNA Circularization Enhances Translation and Promotes Lymphatic Metastasis of Bladder Cancer
Authors: Zhao Yue , Chen Jiancheng , Zheng Hanhao , Luo Yuming , An Mingjie , Lin Yan , Pang Mingrui , Li Yuanlong , Kong Yao , He Wang , Lin Tianxin , Chen Changhao
Published: February 2024

Figure S9
Supplementary Data from Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells
Authors: Guo Xiaofan , Qiu Wei , Wang Chaochao , Qi Yanhua , Li Boyan , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Gao Zijie , Pan Ziwen , Zhao Shulin , Li Gang , Xue Hao
Published: February 2024

Figure S3. Original western blots 3
Supplementary Data from Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells
Authors: Guo Xiaofan , Qiu Wei , Wang Chaochao , Qi Yanhua , Li Boyan , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Gao Zijie , Pan Ziwen , Zhao Shulin , Li Gang , Xue Hao
Published: February 2024

Figure S5. The effect of A-NDEs on GSCs and GBM cells
Supplementary Data from Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells
Authors: Guo Xiaofan , Qiu Wei , Wang Chaochao , Qi Yanhua , Li Boyan , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Gao Zijie , Pan Ziwen , Zhao Shulin , Li Gang , Xue Hao
Published: February 2024

Figure S8. A-NDEs promotes the radioresistance in GSCs
Supplementary Data from Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells
Authors: Guo Xiaofan , Qiu Wei , Wang Chaochao , Qi Yanhua , Li Boyan , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Gao Zijie , Pan Ziwen , Zhao Shulin , Li Gang , Xue Hao
Published: February 2024

Figure S9. Neuronal activity promote the PMT of GSCs in vivo
Supplementary Data from Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells
Authors: Guo Xiaofan , Qiu Wei , Wang Chaochao , Qi Yanhua , Li Boyan , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Gao Zijie , Pan Ziwen , Zhao Shulin , Li Gang , Xue Hao
Published: February 2024

Figure S12. Gene Ontologies analysis and validation of four categories of genes
Supplementary Data from Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells
Authors: Guo Xiaofan , Qiu Wei , Wang Chaochao , Qi Yanhua , Li Boyan , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Gao Zijie , Pan Ziwen , Zhao Shulin , Li Gang , Xue Hao
Published: February 2024

Figure S17. RBM15 regulates the expression of DLG3 in an m6A-dependent manner
Supplementary Data from Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells
Authors: Guo Xiaofan , Qiu Wei , Wang Chaochao , Qi Yanhua , Li Boyan , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Gao Zijie , Pan Ziwen , Zhao Shulin , Li Gang , Xue Hao
Published: February 2024

Figure S19. A-NDEs promote GSCs PMT via p-STAT3 pathway
Data from SUMOylation-Driven mRNA Circularization Enhances Translation and Promotes Lymphatic Metastasis of Bladder Cancer
Authors: Zhao Yue , Chen Jiancheng , Zheng Hanhao , Luo Yuming , An Mingjie , Lin Yan , Pang Mingrui , Li Yuanlong , Kong Yao , He Wang , Lin Tianxin , Chen Changhao
Published: February 2024

Abstract
Aberrant gene expression is a prominent feature of metastatic cancer. Translational initiation is a vital step in fine-tuning gene expression. Thus, exploring translation initiation regulators may identify therapeutic targets for preventing and treating metastasis. Herein, we identified that DHCR24 was overexpressed in lymph node (LN) metastatic bladder cancer and correlated with poor prognosis of patients. DHCR24 promoted lymphangiogenesis and LN metastasis of bladder cancer in vitro and in vivo. Mechanistically, DHCR24 mediated and recognized the SUMO2 modification at lysine 108 of hnRNPA2B1 to foster TBK1 mRNA circularization and eIF4F initiation complex assembly by enhancing hnRNPA2B1–eIF4G1 interaction. Moreover, DHCR24 directly anchored to TBK1 mRNA 3′-untranslated region to increase its stability, thus forming a feed forward loop to elevate TBK1 expression. TBK1 activated PI3K/Akt signaling to promote VEGFC secretion, resulting in lymphangiogenesis and LN metastasis. DHCR24 silencing significantly impeded bladder cancer lymphangiogenesis and lymphatic metastasis in a patient-derived xenograft model. Collectively, these findings elucidate DHCR24-mediated translation machinery that promotes lymphatic metastasis of bladder cancer and supports the potential application of DHCR24-targeted therapy for LN-metastatic bladder cancer.
Significance:
DHCR24 is a SUMOylation regulator that controls translation initiation complex assembly and orchestrates TBK1 mRNA circularization to activate Akt/VEGFC signaling, which stimulates lymphangiogenesis and promotes lymph node metastasis in bladder cancer.
Risk Factors for Ovarian Cancer by BRCA Status: A Collaborative Case-Only Analysis
Authors: Gersekowski Kate , Na Renhua , Alsop Kathryn , Delahunty Rachel , Goode Ellen L. , Cunningham Julie M. , Winham Stacey J. , Pharoah Paul D.P. , Song Honglin , Webb Penelope M.
Published: February 2024

Background:

Women with an inherited pathogenic variant in BRCA1 or BRCA2 have a greatly increased risk of developing ovarian cancer, but the importance of behavioral factors is less clear. We used a case-only design to compare the magnitude of associations with established reproductive, hormonal, and lifestyle risk factors between BRCA mutation carriers and noncarriers.

Methods:

We pooled data from five studies from the Ovarian Cancer Association Consortium including 637 BRCA carriers and 4,289 noncarriers. Covariate-adjusted generalized linear mixed models were used to estimate interaction risk ratios (IRR) and 95% confidence intervals (CI), with BRCA (carrier vs. noncarrier) as the response variable.

Results:

IRRs were above 1.0 for known protective factors including ever being pregnant (IRR = 1.29, 95% CI; 1.00–1.67) and ever using the oral contraceptive pill (1.30, 95% CI; 1.07–1.60), suggesting the protective effects of these factors may be reduced in carriers compared with noncarriers. Conversely, the IRRs for risk factors including endometriosis and menopausal hormone therapy were below 1.0, suggesting weaker positive associations among BRCA carriers. In contrast, associations with lifestyle factors including smoking, physical inactivity, body mass index, and aspirin use did not appear to differ by BRCA status.

Conclusions:

Our results suggest that associations with hormonal and reproductive factors are generally weaker for those with a pathogenic BRCA variant than those without, while associations with modifiable lifestyle factors are similar for carriers and noncarriers.

Impact:

Advice to maintain a healthy weight, be physically active, and refrain from smoking will therefore benefit BRCA carriers as well as noncarriers.
Supplementary Figure 3 from Modulating Gut Microbiota Prevents Anastomotic Leak to Reduce Local Implantation and Dissemination of Colorectal Cancer Cells after Surgery
Authors: Hajjar Roy , Oliero Manon , Fragoso Gabriela , Ajayi Ayodeji Samuel , Alaoui Ahmed Amine , Vennin Rendos Hervé , Calvé Annie , Cuisiniere Thibault , Gerkins Claire , Thérien Sophie , Taleb Nassima , Dagbert François , Sebajang Herawaty , Loungnarath Rasmy , Schwenter Frank , Ratelle Richard , Wassef Ramses , De Broux Eric , Richard Carole , Santos Manuela M.
Published: February 2024

Supplementary Figure 3. Inulin and 5-ASA supplementation was associated with an improved gut barrier integrity in mice.
Supplementary Table S2 from A Phase Ib First-In-Patient Study Assessing the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ponsegromab in Participants with Cancer and Cachexia
Authors: Crawford Jeffrey , Calle Roberto A. , Collins Susie M. , Weng Yan , Lubaczewski Shannon L. , Buckeridge Clare , Wang Ellen Q. , Harrington Magdalena A. , Tarachandani Anil , Rossulek Michelle I. , Revkin James H.
Published: February 2024

Summary of serum unbound and total ponsegromab Ctrough
Table S5 from Clinical and Immunologic Features of Germline Pathogenic Variant–Positive Patients with Melanoma
Authors: Shen Alan , Arbesman Michelle , Lodha Roshan , Rayman Patricia , Bungo Brandon , Ni Ying , Chan Timothy , Gastman Brian , Ko Jennifer , Diaz-Montero C. Marcela , Arbesman Joshua , Funchain Pauline
Published: February 2024

Multivariable linear regression on PMN-MDSC counts.
Figure S1 from Clinical and Immunologic Features of Germline Pathogenic Variant–Positive Patients with Melanoma
Authors: Shen Alan , Arbesman Michelle , Lodha Roshan , Rayman Patricia , Bungo Brandon , Ni Ying , Chan Timothy , Gastman Brian , Ko Jennifer , Diaz-Montero C. Marcela , Arbesman Joshua , Funchain Pauline
Published: February 2024

Flow cytometry gating scheme.
Supplemental Table S3 from Aneuploidy Landscape in Precursors of Ovarian Cancer
Authors: Wang Yeh , Douville Christopher , Chien Yen-Wei , Wang Brant G. , Chen Chi-Long , Pinto Andre , Smith Saron Ann , Drapkin Ronny , Chui M. Herman , Numan Tricia , Vang Russell , Papadopoulos Nickolas , Wang Tian-Li , Shih Ie-Ming
Published: February 2024

RealseqS data of all the lesions analyzed.
Supplementary Tables 1 from Impact of Rare Structural Variant Events in Newly Diagnosed Multiple Myeloma
Authors: Chojnacka Monika , Diamond Benjamin , Ziccheddu Bachisio , Rustad Even , Maclachlan Kylee , Papadimitriou Marios , Boyle Eileen M. , Blaney Patrick , Usmani Saad , Morgan Gareth , Landgren Ola , Maura Francesco
Published: February 2024

Supplementary Tables
Supplementary Table S2 from Phase I Study of Elraglusib (9-ING-41), a Glycogen Synthase Kinase-3β Inhibitor, as Monotherapy or Combined with Chemotherapy in Patients with Advanced Malignancies
Authors: Carneiro Benedito A. , Cavalcante Ludimila , Mahalingam Devalingam , Saeed Anwaar , Safran Howard , Ma Wen Wee , Coveler Andrew L. , Powell Steven , Bastos Bruno , Davis Elizabeth , Sahai Vaibhav , Mikrut William , Longstreth James , Smith Sheri , Weisskittel Taylor , Li Hu , Borden Brittany A. , Harvey R. Donald , Sahebjam Solmaz , Cervantes Andrés , Koukol Austin , Mazar Andrew P. , Steeghs Neeltje , Kurzrock Razelle , Giles Francis J. , Munster Pamela
Published: February 2024

Representativeness of patient population
Supplementary Figure S8 from Phase I Study of Elraglusib (9-ING-41), a Glycogen Synthase Kinase-3β Inhibitor, as Monotherapy or Combined with Chemotherapy in Patients with Advanced Malignancies
Authors: Carneiro Benedito A. , Cavalcante Ludimila , Mahalingam Devalingam , Saeed Anwaar , Safran Howard , Ma Wen Wee , Coveler Andrew L. , Powell Steven , Bastos Bruno , Davis Elizabeth , Sahai Vaibhav , Mikrut William , Longstreth James , Smith Sheri , Weisskittel Taylor , Li Hu , Borden Brittany A. , Harvey R. Donald , Sahebjam Solmaz , Cervantes Andrés , Koukol Austin , Mazar Andrew P. , Steeghs Neeltje , Kurzrock Razelle , Giles Francis J. , Munster Pamela
Published: February 2024

Plasma Elraglusib (9-ING-41) Concentrations 3.3 mg/kg Elraglusib plus a Paclitaxel plus Carboplatin Regimen
Supplementary Figure S10 from Phase I Study of Elraglusib (9-ING-41), a Glycogen Synthase Kinase-3β Inhibitor, as Monotherapy or Combined with Chemotherapy in Patients with Advanced Malignancies
Authors: Carneiro Benedito A. , Cavalcante Ludimila , Mahalingam Devalingam , Saeed Anwaar , Safran Howard , Ma Wen Wee , Coveler Andrew L. , Powell Steven , Bastos Bruno , Davis Elizabeth , Sahai Vaibhav , Mikrut William , Longstreth James , Smith Sheri , Weisskittel Taylor , Li Hu , Borden Brittany A. , Harvey R. Donald , Sahebjam Solmaz , Cervantes Andrés , Koukol Austin , Mazar Andrew P. , Steeghs Neeltje , Kurzrock Razelle , Giles Francis J. , Munster Pamela
Published: February 2024

Progression-Free Survival (A) and Overall Survival (B) with Elraglusib in Combination with Chemotherapy
Supplementary Table 3 from Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer
Authors: Byrne Katelyn T. , Betts Courtney B. , Mick Rosemarie , Sivagnanam Shamilene , Bajor David L. , Laheru Daniel A. , Chiorean E. Gabriela , O'Hara Mark H. , Liudahl Shannon M. , Newcomb Craig , Alanio Cécile , Ferreira Ana P. , Park Byung S. , Ohtani Takuya , Huffman Austin P. , Väyrynen Sara A. , Dias Costa Andressa , Kaiser Judith C. , Lacroix Andreanne M. , Redlinger Colleen , Stern Martin , Nowak Jonathan A. , Wherry E. John , Cheever Martin A. , Wolpin Brian M. , Furth Emma E. , Jaffee Elizabeth M. , Coussens Lisa M. , Vonderheide Robert H.
Published: February 2024

Table S3 provides details of the ROIs presented in Figure 3B-C and the cell population densities within the ROIs.
Data from Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR+ Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase IIb Trial
Authors: Wildiers Hans , Armstrong Anne , Cuypere Eveline , Dalenc Florence , Dirix Luc , Chan Steve , Marme Frederik , Schröder Carolina P. , Huober Jens , Duhoux Francois P. , Vuylsteke Peter , Jager Agnes , Brain Etienne , Kuemmel Sherko , Pápai Zsuzsanna , Menke-van der Houven van Oordt Catharina Willemien , Perjesi Luca , Mueller Christian , Brignone Chrystelle , Triebel Frederic
Published: February 2024

AbstractPurpose:
Eftilagimod alpha (efti), a soluble lymphocyte activation gene (LAG-3) protein and MHC class II agonist, enhances innate and adaptive immunity. Active Immunotherapy PAClitaxel (AIPAC) evaluated safety and efficacy of efti plus paclitaxel in patients with predominantly endocrine-resistant, hormone receptor–positive, HER2-negative metastatic breast cancer (ET-resistant HR+ HER2− MBC).
Patients and Methods:
Women with HR+ HER2– MBC were randomized 1:1 to weekly intravenous paclitaxel (80 mg/m2) and subcutaneous efti (30 mg) or placebo every 2 weeks for six 4-week cycles, then monthly subcutaneous efti (30 mg) or placebo maintenance. Primary endpoint was progression-free survival (PFS) by blinded independent central review. Secondary endpoints included overall survival (OS), safety/tolerability, pharmacokinetics/pharmacodynamics, and quality of life. Exploratory endpoints included cellular biomarkers.
Results:
114 patients received efti and 112 patients received placebo. Median age was 60 years (91.6% visceral disease, 84.1% ET-resistant, 44.2% with previous CDK4/6 inhibitor treatment). Median PFS at 7.3 months was similar for efti and placebo. Median OS was not significantly improved for efti (20.4 vs. 17.5 months; HR, 0.88; P = 0.197) but became significant for predefined exploratory subgroups. EORTC QLQC30-B23 global health status was sustained for efti but deteriorated for placebo. Efti increased absolute lymphocyte, monocyte and secondary target cell (CD4, CD8) counts, plasma IFNγ and CXCL10 levels.
Conclusions:
Although the primary endpoint, PFS, was not met, AIPAC confirmed expected pharmacodynamic effects and demonstrated excellent safety profile for efti. OS was not significantly improved globally (2.9-month difference), but was significantly improved in exploratory biomarker subgroups, warranting further studies to clarify efti's role in patients with ET-resistant HER2− MBC.
Data from PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer
Authors: Ali Lestat R. , Lenehan Patrick J. , Cardot-Ruffino Victoire , Dias Costa Andressa , Katz Matthew H.G. , Bauer Todd W. , Nowak Jonathan A. , Wolpin Brian M. , Abrams Thomas A. , Patel Anuj , Clancy Thomas E. , Wang Jiping , Mancias Joseph D. , Reilley Matthew J. , Stucky Chee-Chee H. , Bekaii-Saab Tanios S. , Elias Rawad , Merchant Nipun , Slingluff Craig L. , Rahma Osama E. , Dougan Stephanie K.
Published: February 2024

AbstractPurpose:
Pancreatic ductal adenocarcinoma (PDAC) trials have evaluated CTLA-4 and/or PD-(L)1 blockade in patients with advanced disease in which bulky tumor burden and limited time to develop antitumor T cells may have contributed to poor clinical efficacy. Here, we evaluated peripheral blood and tumor T cells from patients with PDAC receiving neoadjuvant chemoradiation plus anti–PD-1 (pembrolizumab) versus chemoradiation alone. We analyzed whether PD-1 blockade successfully reactivated T cells in the blood and/or tumor to determine whether lack of clinical benefit could be explained by lack of reactivated T cells versus other factors.
Experimental Design:
We used single-cell transcriptional profiling and TCR clonotype tracking to identify TCR clonotypes from blood that match clonotypes in the tumor.
Results:
PD-1 blockade increases the flux of TCR clonotypes entering cell cycle and induces an IFNγ signature like that seen in patients with other GI malignancies who respond to PD-1 blockade. However, these reactivated T cells have a robust signature of NF-κB signaling not seen in cases of PD-1 antibody response. Among paired samples between blood and tumor, several of the newly cycling clonotypes matched activated T-cell clonotypes observed in the tumor.
Conclusions:
Cytotoxic T cells in the blood of patients with PDAC remain sensitive to reinvigoration by PD-1 blockade, and some have tumor-recognizing potential. Although these T cells proliferate and have a signature of IFN exposure, they also upregulate NF-κB signaling, which potentially counteracts the beneficial effects of anti–PD-1 reinvigoration and marks these T cells as non-productive contributors to antitumor immunity.

See related commentary by Lander and DeNardo, p. 474
Data from First-in-Human Study with Preclinical Data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors
Authors: Lakhani Nehal J. , Rasco Drew , Wang Hengbang , Men Lichuang , Liang Eric , Fu Tommy , Collins Mary C. , Min Ping , Yin Yan , Davids Matthew S. , Yang Dajun , Zhai Yifan
Published: February 2024

AbstractPurpose:
B-cell lymphoma-extra-large (BCL-xL) regulates apoptosis and is an attractive anticancer therapeutic target. However, BCL-xL inhibition also kills mature platelets, hampering clinical development. Using an innovative prodrug strategy, we have developed pelcitoclax (APG-1252), a potent, dual BCL-2 and BCL-xL inhibitor. Aims of this study were to characterize the antitumor activity and safety of pelcitoclax and explore its underlying mechanisms of action (MOA).
Patients and Methods:
Cell line–derived xenograft and patient-derived xenograft (PDX) models were tested to evaluate antitumor activity and elucidate MOA. Subjects (N = 50) with metastatic small-cell lung cancer and other solid tumors received intravenous pelcitoclax once or twice weekly. Primary outcome measures were safety and tolerability; preliminary efficacy (responses every 2 cycles per RECIST version 1.1) represented a secondary endpoint.
Results:
Pelcitoclax exhibited strong BAX/BAK‒dependent and caspase-mediated antiproliferative and apoptogenic activity in various cancer cell lines. Consistent with cell-based apoptogenic activity, pelcitoclax disrupted BCL-xL:BIM and BCL-xL:PUMA complexes in lung and gastric cancer PDX models. Levels of BCL-xL complexes correlated with tumor growth inhibition by pelcitoclax. Combined with taxanes, pelcitoclax enhanced antitumor activity by downregulating antiapoptotic protein myeloid cell leukemia-1 (MCL-1). Importantly, pelcitoclax was well tolerated and demonstrated preliminary therapeutic efficacy, with overall response and disease control rates of 6.5% and 30.4%, respectively. Most common treatment-related adverse events included transaminase elevations and reduced platelets that were less frequent with a once-weekly schedule.
Conclusions:
Our data demonstrate that pelcitoclax has antitumor activity and is well tolerated, supporting its further clinical development for human solid tumors, particularly combined with agents that downregulate MCL-1.
Supplementary figure 3 from Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates
Authors: Schmitt Saskia , Machui Paul , Mai Isabelle , Herterich Sarah , Wunder Swetlana , Cyprys Philipp , Gerlach Marcus , Ochtrop Philipp , Hackenberger Christian P.R. , Schumacher Dominik , Helma Jonas , Vogl Annette M. , Kasper Marc-André
Published: February 2024

Hydrophobic interaction chromatography measurements. Comparison of trastuzumab, trastuzumab-LP3 DAR8, trastuzumab-LP5 DAR8, Adcetris and Enhertu. Shown are chromatograms of Adcetris in black (Homogenous ADC, brentuximab conjugated to MC-VC-PAB-MMAE in DAR0, DAR2, DAR4, DAR6 and DAR8). Enhertu in grey, trastuzumab in light orange, trastuzumab-LP5 in orange and brentuximab-LP3 in purple. Hydrophilicity of all shown DAR8 VC-PAB-Exatecan constructs are in the range of a DAR2 of Adcetris.
Supplementary Figure S8-2 from Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models
Authors: Friese-Hamim Manja , Ortiz Ruiz Maria J. , Bogatyrova Olga , Keil Marina , Rohdich Felix , Blume Beatrix , Leuthner Birgitta , Czauderna Frank , Hahn Diane , Jabs Julia , Jaehrling Frank , Heinrich Timo , Kellner Roland , Chan Katherine , Tong Amy H.Y. , Wienke Dirk , Moffat Jason , Blaukat Andree , Zenke Frank T.
Published: February 2024

Body weight curves of gastric cancer PDX model GXF-1172-bearing mice treated with vehicle or M8891 (150 mg/kg, twice daily, per os) as monotherapy
Supplementary Figure S6-1 from Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models
Authors: Friese-Hamim Manja , Ortiz Ruiz Maria J. , Bogatyrova Olga , Keil Marina , Rohdich Felix , Blume Beatrix , Leuthner Birgitta , Czauderna Frank , Hahn Diane , Jabs Julia , Jaehrling Frank , Heinrich Timo , Kellner Roland , Chan Katherine , Tong Amy H.Y. , Wienke Dirk , Moffat Jason , Blaukat Andree , Zenke Frank T.
Published: February 2024

SDS-PAGE analysis of rabbit monoclonal antibody MKV-3-165-11 before and after purification by Protein A affinity chromatography
Supplementary Figure S11-8 from Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models
Authors: Friese-Hamim Manja , Ortiz Ruiz Maria J. , Bogatyrova Olga , Keil Marina , Rohdich Felix , Blume Beatrix , Leuthner Birgitta , Czauderna Frank , Hahn Diane , Jabs Julia , Jaehrling Frank , Heinrich Timo , Kellner Roland , Chan Katherine , Tong Amy H.Y. , Wienke Dirk , Moffat Jason , Blaukat Andree , Zenke Frank T.
Published: February 2024

Body weight curves for RCC PDX model RXF-2796-bearing mice treated with vehicle, M8891 (100 mg/kg, daily, per os), cabozantinib (10 mg/kg, daily, per os), or the combination are shown
Supplementary Figure S11-6 from Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models
Authors: Friese-Hamim Manja , Ortiz Ruiz Maria J. , Bogatyrova Olga , Keil Marina , Rohdich Felix , Blume Beatrix , Leuthner Birgitta , Czauderna Frank , Hahn Diane , Jabs Julia , Jaehrling Frank , Heinrich Timo , Kellner Roland , Chan Katherine , Tong Amy H.Y. , Wienke Dirk , Moffat Jason , Blaukat Andree , Zenke Frank T.
Published: February 2024

Body weight curves for RCC PDX model RXF-2717-bearing mice treated with vehicle, M8891 (100 mg/kg, daily, per os), cabozantinib (10 mg/kg, daily, per os), or the combination are shown
Figure S1 from Effects of Combined Therapeutic Targeting of AXL and ATR on Pleural Mesothelioma Cells
Authors: Hirai Soichi , Yamada Tadaaki , Katayama Yuki , Ishida Masaki , Kawachi Hayato , Matsui Yohei , Nakamura Ryota , Morimoto Kenji , Horinaka Mano , Sakai Toshiyuki , Sekido Yoshitaka , Tokuda Shinsaku , Takayama Koichi
Published: February 2024

Figure S1
Supplementary Figure S1-1 from Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models
Authors: Friese-Hamim Manja , Ortiz Ruiz Maria J. , Bogatyrova Olga , Keil Marina , Rohdich Felix , Blume Beatrix , Leuthner Birgitta , Czauderna Frank , Hahn Diane , Jabs Julia , Jaehrling Frank , Heinrich Timo , Kellner Roland , Chan Katherine , Tong Amy H.Y. , Wienke Dirk , Moffat Jason , Blaukat Andree , Zenke Frank T.
Published: February 2024

Increasing concentrations of M8891 (3E−09M to 1E−04M) were tested in an MetAP1 enzyme assay
Figure S9 from CD38 x ICAM-1 Bispecific Antibody Is a Novel Approach for Treating Multiple Myeloma and Lymphoma
Authors: Chen Xiaocheng , Wong Oi Kwan , Reiman Lauren , Sherbenou Daniel W. , Post Leonard
Published: February 2024

Body weight change profiles in in-vivo studies