bluuebunny/crossref_metadata_2025 huggingface dataset:
On the complexity of IgE: The role of structural flexibility and glycosylation for binding its receptors
Authors: Plattner Kevin , Bachmann Martin F. , Vogel Monique
Published: March 2023

It is well established that immunoglobulin E (IgE) plays a crucial role in atopy by binding to two types of Fcε receptors (FcεRI and FcεRII, also known as CD23). The cross-linking of FcεRI-bound IgE on effector cells, such as basophils and mast cells, initiates the allergic response. Conversely, the binding of IgE to CD23 modulates IgE serum levels and antigen presentation. In addition to binding to FcεRs, IgE can also interact with other receptors, such as certain galectins and, in mice, some FcγRs. The binding strength of IgE to its receptors is affected by its valency and glycosylation. While FcεRI shows reduced binding to IgE immune complexes (IgE-ICs), the binding to CD23 is enhanced. There is no evidence that galectins bind IgE-ICs. On the other hand, IgE glycosylation plays a crucial role in the binding to FcεRI and galectins, whereas the binding to CD23 seems to be independent of glycosylation. In this review, we will focus on receptors that bind to IgE and examine how the glycosylation and complexation of IgE impact their binding.
Research progress on diagnosing retinal vascular diseases based on artificial intelligence and fundus images
Authors: Ji Yuke , Ji Yun , Liu Yunfang , Zhao Ying , Zhang Liya
Published: March 2023

As the only blood vessels that can directly be seen in the whole body, pathological changes in retinal vessels are related to the metabolic state of the whole body and many systems, which seriously affect the vision and quality of life of patients. Timely diagnosis and treatment are key to improving vision prognosis. In recent years, with the rapid development of artificial intelligence, the application of artificial intelligence in ophthalmology has become increasingly extensive and in-depth, especially in the field of retinal vascular diseases. Research study results based on artificial intelligence and fundus images are remarkable and provides a great possibility for early diagnosis and treatment. This paper reviews the recent research progress on artificial intelligence in retinal vascular diseases (including diabetic retinopathy, hypertensive retinopathy, retinal vein occlusion, retinopathy of prematurity, and age-related macular degeneration). The limitations and challenges of the research process are also discussed.
Women and planetary health in Asia-Pacific
Authors: Gan Connie Cai Ru , McNamara Caitlin , Gunasiri Hasini , Oliva Pats , Sebar Bernadette
Published: March 2023

In the face of climate change, women's preconceived vulnerability and virtuousness often deflect focus from gender inequality in decision-making and leadership. Within environmental, political, and social crises, women are capable and proficient leaders who are pivotal to climate change action and are already inspiring social change in innovative ways. This article presents examples of women-led environment movements in the Asia-Pacific that challenge the patriarchal notions that women must be rescued rather than actively participate in their salvation. Historically, strategies have been centered on eco-conscious activism and organized protests. As climate change effects become more evident, engagement has transformed into emergency response and preparedness, with women's groups shepherding and leveraging through healthcare settings and grassroots and community networks. The way forward is to urge meaningful policy actions to support women as effective planetary stewards and campaigners against environmental challenges. This will be achieved through funding mechanisms, gender-inclusive representation mentorships, and pathways that transcend political boundaries.
Task-specific speech enhancement and data augmentation for improved multimodal emotion recognition under noisy conditions
Authors: Kshirsagar Shruti , Pendyala Anurag , Falk Tiago H.
Published: March 2023

Automatic emotion recognition (AER) systems are burgeoning and systems based on either audio, video, text, or physiological signals have emerged. Multimodal systems, in turn, have shown to improve overall AER accuracy and to also provide some robustness against artifacts and missing data. Collecting multiple signal modalities, however, can be very intrusive, time consuming, and expensive. Recent advances in deep learning based speech-to-text and natural language processing systems, however, have enabled the development of reliable multimodal systems based on speech and text while only requiring the collection of audio data. Audio data, however, is extremely sensitive to environmental disturbances, such as additive noise, thus faces some challenges when deployed “in the wild.” To overcome this issue, speech enhancement algorithms have been deployed at the input signal level to improve testing accuracy in noisy conditions. Speech enhancement algorithms can come in different flavors and can be optimized for different tasks (e.g., for human perception vs. machine performance). Data augmentation, in turn, has also been deployed at the model level during training time to improve accuracy in noisy testing conditions. In this paper, we explore the combination of task-specific speech enhancement and data augmentation as a strategy to improve overall multimodal emotion recognition in noisy conditions. We show that AER accuracy under noisy conditions can be improved to levels close to those seen in clean conditions. When compared against a system without speech enhancement or data augmentation, an increase in AER accuracy of 40% was seen in a cross-corpus test, thus showing promising results for “in the wild” AER.
The development of the reading comprehension—Progress monitoring (RC-PM) tool for late elementary students
Authors: Bogaert Rielke , Merchie Emmelien , Aesaert Koen , Van Keer Hilde
Published: March 2023

Notwithstanding reading comprehension is a key competence in today’s society, many late elementary students struggle with it. In this respect, effective instructional incentives are required to foster students’ reading comprehension. However, appropriate assessment instruments to monitor students’ reading comprehension on a regular basis and to make substantiated instructional decisions are lacking. Therefore, a Reading Comprehension – Progress Monitoring tool was developed, consisting of six parallel tests equivalent in difficulty and length. To this aim, classical test theory analyses, item response theory analyses, and automated test assembly were conducted (n = 3,269 students). Suggestions for future research and practice are discussed.
Comparison of the efficacy and safety of picosecond Nd:YAG laser (1,064 nm), picosecond alexandrite laser (755 nm) and 2% hydroquinone cream in the treatment of melasma: A randomized, controlled, assessor-blinded trial
Authors: Liang Surong , Shang Shuai , Zhang Wensi , Tan Ansheng , Zhou Boyang , Mei Xueling , Li Linfeng
Published: March 2023

Background

Increasing numbers of studies demonstrated that picosecond lasers (Picos) were effective and safe for melasma. However, A limited number of randomized controlled trials (RCTs) regarding Picos contribute to a modest level of evidence. Topical hydroquinone (HQ) remains to be the first-line therapy.

Objective

To compare the efficacy and safety of non-fractional picosecond Nd:YAG laser (PSNYL), non-fractional picosecond alexandrite laser (PSAL), and 2% HQ cream in the treatment of melasma.

Method

Sixty melasma patients with Fitzpatrick skin types (FST) III-IV were randomly assigned to the PSNY, PSAL, and HQ groups at a 1:1:1 ratio. Patients in PSNYL and PSAL groups received 3 laser sessions at 4-week intervals. The 2% HQ cream was applied twice daily for 12 weeks in patients of the HQ group. The primary outcome, the melasma area and severity index (MASI) score, was evaluated at weeks 0, 4, 8, 12, 16, 20, and 24. The patient assessment score by quartile rating scale was rated at weeks 12, 16, 20, and 24.

Results

Fifty-nine (98.3%) subjects were included in the analysis. Each group showed significant change from baseline in MASI scores from week 4 to week 24. The MASI score in the PSNYL group showed the greatest reduction compared to the PSAL group (p = 0.016) and HQ group (p = 0.018). The PSAL group demonstrated comparable MASI improvement as the HQ group (p = 0.998). The PSNYL group had the highest patient assessment score, followed by the PSAL group and then the HQ group, although only the differences between PSNYL and HQ groups at weeks 12 and 16 were significant. Four patients (6.8%) experienced recurrence. Other unanticipated events were transient and subsided after 1 week to 6 months.

Conclusion

The efficacy of non-fractional PSNYL was superior to that of non-fractional PSAL, which was not inferior to 2% HQ, thus non-fractional Picos providing an alternative for melasma patients with FSTs III-IV. The safety profiles of PSNYL, PSAL, and 2% HQ cream were similar.

Clinical Trial Registration

https://www.chictr.org.cn/showprojen.aspx?proj=130994, ChiCTR2100050089.
The mediating role of early maladaptive schemas on the relationship between illness perception and pain coping strategies among adolescents diagnosed with migraine
Authors: Kayar Ozan , Altinoğlu Dikmeer İlkiz , Güler Aksu Gülen , Toros Fevziye , Özge Aynur
Published: March 2023

Objective

This study aimed to examine the mediating role of early maladaptive schemas on the relationship between illness-related perceptions and pain coping strategies among adolescents diagnosed with migraine.

Material and methods

A total of 134 adolescents (aged 12–18 years) diagnosed with migraine with and without aura participated in the study. The Illness Perception Questionnaire, the Pain Coping Questionnaire, and the Early Maladaptive Schema Questionnaires Set for Children and Adolescents were used.

Results

The intensity of using desperate ways of coping with pain was higher among adolescents who perceive migraine as a chronic disease (β = 0.199, p < 0.05) even if they have episodic attacks and who have higher levels of coherency in understanding the illness (β = 0.256, p < 0.01). First, full mediations of over-vigilance/inhibition and impaired autonomy/performance schema domains on these relations were observed. Second, the increases in negative cognitive (β = 0.199, p < 0.05) and emotional (β = 0.280, p < 0.01) representations related to the consequences of the illness lead to an increase in the uncontrolled and frequent use of analgesic drugs where the partial mediating role of over-vigilance/inhibition schema domain on this correlation is observed. The perceptions about the negative as well as serious consequences of migraine are related to both the self-active behaviors (β = 0.181, p < 0.05) and the conscious cognitive attempts (β = 0.207, p < 0.05) as effective coping strategies, which is an unexpected finding. The disconnection/rejection schema domain had a full mediation role on both relations.

Conclusion

The results suggest that early maladaptive schemas are essential factors that affect the migraine coping processes of adolescents.
Vigilance decrement and mind-wandering in sustained attention tasks: Two sides of the same coin?
Authors: Martínez-Pérez Víctor , Andreu Almudena , Sandoval-Lentisco Alejandro , Tortajada Miriam , Palmero Lucía B. , Castillo Alejandro , Campoy Guillermo , Fuentes Luis J.
Published: March 2023

Background

Decrements in performance and the propensity for increased mind-wandering (i.e., task-unrelated thoughts) across time-on-task are two pervasive phenomena observed when people perform vigilance tasks. In the present study, we asked whether processes that lead to vigilance decrement and processes that foster the propensity for mind-wandering (MW) can be dissociated or whether they share a common mechanism. In one experiment, we introduced two critical manipulations: increasing task demands and applying anodal high-definition transcranial direct current stimulation (HD-tDCS) to the left dorsolateral prefrontal cortex.

Method

Seventy-eight participants were randomly assigned to one of four groups resulting from the factorial combination of task demand (low, high) and stimulation (anodal, sham). Participants completed the sustained attention to response task (SART), which included thought probes on intentional and unintentional MW. In addition, we investigated the crucial role of alpha oscillations in a novel approach. By assessing pre-post resting EEG, we explored whether participants’ variability in baseline alpha power predicted performance in MW and vigilance decrement related to tDCS or task demands, respectively, and whether such variability was a stable characteristic of participants.

Results

Our results showed a double dissociation, such that task demands exclusively affected vigilance decrement, while anodal tDCS exclusively affected the rate of MW. Furthermore, the slope of the vigilance decrement function and MW rate (overall, intentional and unintentional) did not correlate. Critically, resting state alpha-band activity predicted tDCS-related gains in unintentional MW alone, but not in vigilance decrement, and remained stable after participants completed the task.

Conclusion

These results show that when a sustained attention task involving executive vigilance, such as the SART, is designed to elicit both vigilance decrement effects and MW, the processes leading to vigilance decrement should be differentiated from those responsible for MW, a claim that is supported by the double dissociation observed here and the lack of correlation between the measures chosen to assess both phenomena. Furthermore, the results provide the first evidence of how individual differences in alpha power at baseline may be of crucial importance in predicting the effects of tDCS on MW propensity.
Dorsolateral prefrontal cortex dysfunction caused by a go/no-go task in children with attention-deficit hyperactivity disorder: A functional near-infrared spectroscopy study
Authors: Wu Ting , Liu Xiaoli , Cheng Fang , Wang Shuai , Li Chang , Zhou Dongsheng , Zhang Wenwu
Published: March 2023

Background

Children with attention-deficit hyperactivity disorder (ADHD) exhibit executive function deficits, which can be attributed to a dysfunction in the prefrontal region of the brain. Our study aims to evaluate the alteration of brain activity in children with ADHD during the administration of a go/no-go task using functional near-infrared spectroscopy (fNIRS) in comparison to a control group containing typically developing (TD) children.

Methods

32 children with ADHD and 31 of their TD peers were recruited and asked to perform a go/no-go task while undergoing measurements, with the aim of detecting changes in average oxygenated hemoglobin signaling (Δavg oxy-Hb) via fNIRS in the prefrontal lobe.

Results

fNIRS data showed significant differences between the left and right dorsolateral prefrontal cortices, with a lower Δavg oxy-Hb change in the ADHD group compared to the TD group.

Conclusion

Our results indicate that brain dysfunction in children with ADHD is related to functional impairments in the dorsolateral prefrontal cortex. The go/no-go task paired with fNIRS represents a useful measurement tool to assess prefrontal brain dysfunction in children struggling with ADHD.
The multiple factors of suboptimal early feeding practices among infants aged 0–5 months in Indonesia
Authors: Titaley Christiana Rialine , Wijayanti Ratna U. , Mu'asyaroh Anifatun , Ariawan Iwan
Published: March 2023

Background

Optimal early infant feeding practices are critical to ensure adequate nutrition for infants’ growth and development. This study aimed to examine the determinants of suboptimal early feeding practices (i.e., delayed initiation of breastfeeding, prelacteal feeding, and non-exclusive breastfeeding) among infants aged 0–5 months in Indonesia.

Methods

We used data collected in the 2012 and 2017 Indonesia Demographic and Health Surveys. Analyses were conducted using information from 3,198 live-born singleton infants aged 0–5 months. The primary outcomes used were: (1) delayed initiation of breastfeeding in the first hour after birth, (2) prelacteal feeding in the first 3 days, and (3) non-exclusive breastfeeding in the last 24 h preceding the survey. Potential predictors analyzed were categorized into the environmental, household, maternal, pregnancy, delivery, and child characteristics. Logistic regression analyses were performed to identify factors significantly associated with each outcome.

Results

Approximately 78,6% of infants aged 0–5 months in Indonesia had at least one of the three suboptimal early infant feeding practices. We found a strong association between the three outcome indicators analyzed. The determinants of delayed initiation of breastfeeding included infants from Sumatera region (adjusted odds ratios (aOR) = 2.02, p < 0.001), infants delivered by Cesarean section (aOR = 2.78, p < 0.001), and in non-health facilities (aOR = 1.53, p = 0.003). The determinants of prelacteal feeding in the first 3 days included infants living in urban areas (aOR = 1.32, p = 0.035), the first birth-ranked infants (aOR = 1.32, p = 0.019), and infants who had delayed initiation of breastfeeding in the first hour of life (aOR = 3.90, p < 0.001). The determinants of non-exclusive breastfeeding in the last 24 h included infants whose mothers worked in non-agricultural fields (aOR = 1.52, p < 0.001), infants delivered by Cesarean section (aOR = 1.33, p = 0.044), and the first birth-ranked infants (aOR = 1.28, p = 0.039).

Conclusion

There was a high percentage of infants aged 0–5 months who had suboptimal feeding practices in Indonesia. As we found multiple factors associated with suboptimal early feeding practices among infants, integrated approaches, including health promotion and supportive public policy, are required to ensure infants receive adequate nutrition in the early stages of life.
Fish waste to sustainable additives: Fish protein hydrolysates alleviate intestinal dysbiosis and muscle atrophy induced by poultry by-product meal in Lates calcarifer juvenile
Authors: Chaklader Md Reaz , Howieson Janet , Foysal Md Javed , Hanif Md Abu , Abdel-Latif Hany M.R. , Fotedar Ravi
Published: March 2023

Valorising waste from the processing of fishery and aquaculture products into functional additives, and subsequent use in aquafeed as supplements could be a novel approach to promoting sustainability in the aquaculture industry. The present study supplemented 10% of various fish protein hydrolysates (FPHs), obtained from the hydrolysis of kingfish (KH), carp (CH) and tuna (TH) waste, with 90% of poultry by-product meal (PBM) protein to replace fishmeal (FM) completely from the barramundi diet. At the end of the trial, intestinal mucosal barriers damage, quantified by villus area (VA), lamina propria area (LPA), LPA ratio, villus length (VL), villus width (VW), and neutral mucin (NM) in barramundi fed a PBM-based diet was repaired when PBM was supplemented with various FPHs (p < 0.05, 0.01, and 0.001). PBM-TH diet further improved these barrier functions in the intestine of fish (p < 0.05 and 0.001). Similarly, FPHs supplementation suppressed PBM-induced intestinal inflammation by controlling the expression of inflammatory cytokines (tnf-α and il-10; p < 0.05 and 0.001) and a mucin-relevant production gene (i-mucin c; p < 0.001). The 16S rRNA data showed that a PBM-based diet resulted in dysbiosis of intestinal bacteria, supported by a lower abundance of microbial diversity (p < 0.001) aligned with a prevalence of Photobacterium. PBM-FPHs restored intestine homeostasis by enhancing microbial diversity compared to those fed a PBM diet (p < 0.001). PBM-TH improved the diversity (p < 0.001) further by elevating the Firmicutes phylum and the Ruminococcus, Faecalibacterium, and Bacteroides genera. Muscle atrophy, evaluated by fiber density, hyperplasia and hypertrophy and associated genes (igf-1, myf5, and myog), occurred in barramundi fed PBM diet but was repaired after supplementation of FPHs with the PBM (p < 0.05, 0.01, and 0.001). Similarly, creatine kinase, calcium, phosphorous, and haptoglobin were impacted by PBM-based diet (p < 0.05) but were restored in barramundi fed FPHs supplemented diets (p < 0.05 and 0.01). Hence, using circular economy principles, functional FPHs could be recovered from the fish waste applied in aquafeed formulations and could prevent PBM-induced intestinal dysbiosis and muscular atrophy.

GRAPHICAL ABSTRACT
A novel inflammation-related prognostic model for predicting the overall survival of primary central nervous system lymphoma: A real-world data analysis
Authors: Wu Zhentian , Wang Chenyi , Lyu Yao , Lin Zheshen , Lu Ming , Wang Shixiong , Wang Bingxuan , Yang Na , Li Yeye , Wang Jianhong , Duan Xiaohui , Zhang Na , Gao Jing , Zhang Yuan , Hao Miaowang , Wang Zhe , Gao Guangxun , Liang Rong
Published: March 2023

Background

Primary central nervous system lymphoma (PCNSL) is a type of extranodal non-Hodgkin lymphoma. Although there are widely used prognostic scores, their accuracy and practicality are insufficient. Thus, a novel prognostic prediction model was developed for risk stratification of PCNSL patients in our research.

Methods

We retrospectively collected 122 patients with PCNSL from two medical centers in China from January 2010 to June 2022. Among them, 72 patients were used as the development cohort to construct a new model, and 50 patients were used for the validation. Then, by using univariate and multivariate Cox regression analsis and Lasso analysis, the Xijing model was developed and composed of four variables, including lesion number, β2-microglobulin (β2-MG), systemic inflammation response index (SIRI) and Karnofsky performance status (KPS). Finally, we evaluated the Xijing model through internal and external validation.

Results

Compared with the original prognostic scores, the Xijing model has an overall improvement in predicting the prognosis of PCNSL according to the time-dependent area under the curve (AUC), Harrell’s concordance index (C-index), decision curve analysis (DCA), integrated discrimination improvement (IDI) and continuous net reclassification index (NRI). For overall survival (OS) and progression-free survival (PFS), the Xijing model can divide PCNSL patients into three groups, and shows more accurate stratification ability. In addition, the Xijing model can still stratify and predict prognosis similarly better in the elderly with PCNSL and subgroups received high-dose methotrexate (HD-MTX) or Bruton’s tyrosine kinase inhibitors (BTKi). Finally, external validation confirmed the above results.

Conclusions

Integrating four prognostic factors, including imaging findings, tumor burden, systemic inflammation response index, and comprehensive physical condition, we provided a novel prognostic model for PCNSL based on real-world data and evaluated its predictive capacity.
Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomy
Authors: Ge Wanbao , Qu Yuan , Hou Tingting , Zhang Jiayin , Li Qiuju , Yang Lili , Cao Lanqing , Li Jindong , Zhang Shanyong
Published: March 2023

Background

Epithelioid hemangioendothelioma (EHE) is an extremely uncommon malignant neoplasm that originates from vascular endothelial or pre-endothelial cells. In this report, we present the case of patient who was diagnosed with a primary giant EHE of the spine and underwent treatment with total en-bloc spondylectomy (TES).

Case presentation

A 43-year-old male patient with a history of he presented to our hospital with chronic and progressive back pain. Physical examination revealed weakened sensation of acupuncture and touch on the left costal arch, while relatively normal neurological functions were preserved. Radiological examinations identified a giant destructive soft tissue lesion occupying the T8 vertebral region, with moderate destruction of the pedicle and lamina, as well as the 7th left rib. A preoperative biopsy of the 8th vertebra resulted in a diagnosis of epithelioid hemangioendothelioma(EHE). Postoperative immunohistochemical and pathological reports confirmed the presence of EHE in the left ribs and T8 ribs. The patient underwent resection of the 7th left rib and posterior pedicle screw fixation with 8 pairs of screws and a titanium mesh cage. Subsequently, thoracic en bloc spondylectomy was performed on the T8 vertebra. The patient did not receive radiation or chemotherapy following surgery. Over a period of 3 years, the patient remained free of disease and relapse.

Conclusion

The use of transarterial embolization with spherical embolic agents (TES) has been demonstrated to be a safe, effective, and reliable treatment option for hepatic epithelioid hemangioendothelioma (EHE). Nevertheless, it is crucial to conduct long-term follow-up of this patient in order to assess their clinical outcome.
Evaluation of outcome of chemotherapy for breast cancer patients older than 70 years: A SEER-based study
Authors: Pu Shengyu , Xie Peiling , Chen Heyan , Li Yijun , He Jianjun , Zhang Huimin
Published: March 2023

Background

With the aging of the population, the number of elderly breast cancer cases has increased. However, there is a lack of effective randomized clinical trial data to support whether elderly patients should receive chemotherapy. Our goal was to observe the relationship between chemotherapy and breast cancer-specific survival (BCSS) in elderly breast cancer patients and to identify those who could benefit from chemotherapy.

Methods

We collected the data of patients who were diagnosed with invasive ductal carcinoma and older than 70 years in the SEER database from 1995 to 2016. The independent predictors of BCSS were identified by Cox regression analysis. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were performed to eliminate confounding factors.

Results

A total of 142,537 patients were collected, including 21,782 patients in the chemotherapy group and 120,755 patients in the non-chemotherapy group. We identified the same potential predictors of BCSS after PSM and IPTW, such as age, race, grade, stage, therapy, subtype. A nomogram for predicting 3-year, 5-year and 10-year BCSS was constructed. The 3-year, 5-year and 10-year AUCs of the nomogram were 0.842, 0.819, and 0.788. According to the risk stratification of model predictive scores, patients in the high-risk group achieved the greatest improvement in BCSS after receiving chemotherapy.

Conclusions

Our study suggests that women older than 70 years with larger tumors, higher grade, positive nodes, negative hormone receptor and inactive local therapy gain prognostic benefits from chemotherapy, but for those with low- and median-risk, conventional chemotherapy should be administered cautiously.
Neuroprotection of NAD+ and NBP against ischemia/reperfusion brain injury is associated with restoration of sirtuin-regulated metabolic homeostasis
Authors: Wang Xin-Xin , Mao Guang-Hui , Li Qi-Qi , Tang Jie , Zhang Hua , Wang Kang-Lin , Wang Lei , Ni Hong , Sheng Rui , Qin Zheng-Hong
Published: March 2023

Background: Ischemic stroke seriously threatens human health because of high rates of morbidity, mortality and disability. This study compared the effects of nicotinamide adenine dinucleotide (NAD+) and butylphthalide (NBP) on in vitro and in vivo ischemic stroke models.

Methods: Transient middle cerebral artery occlusion/reperfusion (t-MCAO/R) model was established in mice, and the cultured primary cortical neurons were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R). Cerebral infarct volume, neurobehavioral indices, antioxidant activity, ATP level and lactic acid content were determined. The neuroprotective effects of NAD+ or NBP were compared using sirtuin inhibitor niacinamide (NAM).

Results: Intraperitoneal injection of NBP within 4 h or intravenous injection of NAD+ within 1 h after t-MCAO/R significantly reduced the volume of infarcts, cerebral edema, and neurological deficits. Administration of NAD+ and NBP immediately after t-MCAO/R in mice showed similar neuroprotection against acute and long-term ischemic injury. Both NAD+ and NBP significantly inhibited the accumulation of MDA and H2O2 and reduced oxidative stress. NAD+ was superior to NBP in inhibiting lipid oxidation and DNA damage. Furthermore, although both NAD+ and NBP improved the morphology of mitochondrial damage induced by ischemia/reperfusion, NAD+ more effectively reversed the decrease of ATP and increase of lactic acid after ischemia/reperfusion compared with NBP. NAD+ but not NBP treatment significantly upregulated SIRT3 in the brain, but the sirtuin inhibitor NAM could abolish the protective effect of NAD+ and NBP by inhibiting SIRT1 or SIRT3.

Conclusions: These results confirmed the protective effects of NAD+ and NBP on cerebral ischemic injury. NBP and NAD+ showed similar antioxidant effects, while NAD+ had better ability in restoring energy metabolism, possibly through upregulating the activity of SIRT1 and SIRT3. The protection provided by NBP against cerebral ischemia/reperfusion may be achieved through SIRT1.
Feeding broilers with wheat germ, hops and grape seed extract mixture improves growth performance
Authors: Zou Qiangqiang , Meng Weishuang , Li Chunxiao , Wang Tieliang , Li Desheng
Published: March 2023

In the study, Wheat germ, Hops and Grape seed extracts were made into a mixture (BX). The BX was supplemented in AA + broilers diets to investigate the effects of BX on broiler growth performance, blood indicators, microbiota, and noxious gas emissions in faeces. Four hundred and eighty 1-day-old AA + male broilers with an average initial body weight (44.82 ± 0.26) were randomly divided into four dietary treatments of six replicates each, with 20 birds per replicate. The experimental groups consisted of a group fed a basal diet and groups fed basal diet supplemented with 0.05%, 0.1%, and 0.2% BX. The trail was 42 days. The results showed that supplementing the dietary with graded levels of BX linearly increased ADG and ADFI from days 22–42 and 1–42. When dietarys supplemented with 0.2% BX significantly increased ADG and ADFI on days 22–42 and 1–42 (p < 0.05). The addition of BX reduced H2S and NH3 emissions in the faeces; the levels of E. coli and Salmonella in the faeces were significantly reduced and the levels of Lactobacillus were increased (p < 0.05). In this trial, when the diet was supplemented with 0.2% BX, faecal levels of E. coli and Salmonella were consistently at their lowest levels and Lactobacillus were at their highest. At the same time, NH3 and H2S emissions from broiler faecal also had been at their lowest levels. Conclusion: Dietary supplementation with a 0.2% BX could improve the growth performance of broilers and also reduced faecal H2S and NH3 emissions, as well as faecal levels of E. coli and Salmonella, and increased levels of Lactobacillus. Thus, BX made by Wheat germ, Hops and Grape seed extract is expected to be an alternative to antibiotics. And based on the results of this trial, the recommended dose for use in on-farm production was 0.2%.
Online health community for change: Analysis of self-disclosure and social networks of users with depression
Authors: Shi Jiayi , Khoo Zhaowei
Published: March 2023

Background

A key research question with theoretical and practical implications is to investigate the various conditions by which social network sites (SNS) may either enhance or interfere with mental well-being, given the omnipresence of SNS and their dual effects on well-being.

Method/process

We study SNS’ effects on well-being by accounting for users’ personal (i.e., self-disclosure) and situational (i.e., social networks) attributes, using a mixed design of content analysis and social network analysis.

Result/conclusion

We compare users’ within-person changes in self-disclosure and social networks in two phases (over half a year), drawing on Weibo Depression SuperTalk, an online community for depression, and find: ① Several network attributes strengthen social support, including network connectivity, global efficiency, degree centralization, hubs of communities, and reciprocal interactions. ② Users’ self-disclosure attributes reflect positive changes in mental well-being and increased attachment to the community. ③ Correlations exist between users’ topological and self-disclosure attributes. ④ A Poisson regression model extracts self-disclosure attributes that may affect users’ received social support, including the writing length, number of active days, informal words, adverbs, negative emotion words, biological process words, and first-person singular forms.

Innovation

We combine social network analysis with content analysis, highlighting the need to understand SNS’ effects on well-being by accounting for users’ self-disclosure (content) and communication partners (social networks).

Implication/contribution

Authentic user data helps to avoid recall bias commonly found in self-reported data. A longitudinal within-person analysis of SNS’ effects on well-being is helpful for policymakers in public health intervention, community managers for group organizations, and users in online community engagement.
The subjective career success of women: The role of personal resources
Authors: Koekemoer Eileen , Olckers Chantal , Schaap Pieter
Published: March 2023

Introduction

Research on women’s career success has been the subject of extensive investigations, emphasizing the barriers they encounter in their careers. However, far less attention has been given to the personal resources that promote women’s career success. The purpose of our study was to provide more conclusive evidence regarding the role that personal resources such as resilience and grit can play in the relationship between women’s person-environment fit and the perceptions of their career success. Underpinned by the Job Demands Resources and social cognitive theory, our study aims to investigate whether resilience and grit could either explain how person-environment fit translates into feelings of subjective career success or could strengthen this relationship.

Method

A cross-sectional online survey research design was used, and a convenience sample of 408 female employees was obtained. Relationships were explored through structural equation modelling.

Results

When controlling for age, the findings of this study revealed significantly positive relationships between the constructs, with person-environment fit, resilience, and grit, explaining a large portion of the variance in subjective career success. Although our data supported the mediating role of grit and resilience in the person-environment fit and subjective career success relationship, the moderating effects of grit and resilience could not be established.

Discussion

These findings illustrate both grit and resilience as mechanisms that indirectly affect the person-environment fit and subjective career success relationship of women. However, our findings indicate that resilience and grit cannot be considered mechanisms that would buffer against poor person-environment fit’s effect on their career success perceptions. Firstly, our study advances our understanding of the roles personal resources such as resilience and grit play in women’s career success as ways to overcome obstacles and workplace barriers. Secondly, using the motivational process of the Job Demands Resources Framework as theoretical background, we contribute by shedding light on how personal resources (resilience and grit) can be considered underlying factors influencing the person-environment fit and career success relationship for women. If women experience good person-environment fit, there is a greater opportunity for developing resilience and grit and, consequently, subjective career success.
Big Five personality traits in the workplace: Investigating personality differences between employees, supervisors, managers, and entrepreneurs
Authors: Kang Weixi , Guzman Kreisha Lou , Malvaso Antonio
Published: March 2023

Personality relates to employment status. Previous studies have mainly compared the difference between entrepreneurs and managers. It remains unknown how personalities differ in entrepreneurs, managers, supervisors, and employees. In this research, we answer the questions by analyzing data from Understanding Society: the UK Household Longitudinal Study (UKHLS) that consisted of 2,415 entrepreneurs, 3,822 managers, 2,446 supervisors, and 10,897 employees. By using a multivariate analysis of variance (MANOVA) and ANOVA, we found that employment status has a significant multivariate effect on personality traits (F(5, 17,159) = 172.51, p < 0.001) after taking account into demographics. Moreover, there were also significant univariate effects for Neuroticism (F(3,19502) = 16.61, P < 0.001), Openness (F(3,19502) = 3.53, P < 0.05), Agreeableness (F(3,19502) = 66.57, P < 0.001), Conscientiousness (F(3,19502) = 16.39, P < 0.001), and Extraversion (F(3,19502) = 31.61, P < 0.001) after controlling for demographics. Multiple comparisons revealed that entrepreneurs are characterized by low Neuroticism, high Openness, high Conscientiousness, and high Extraversion while managers had low Neuroticism, low Agreeableness, high Openness, high Conscientiousness, and high Extraversion. Finally, supervisors are associated with high Conscientiousness. Implications and limitations are discussed.
Deficits in odor discrimination versus odor identification in patients with schizophrenia and negative correlations with GABAergic and DNA methyltransferase mRNAs in lymphocytes
Authors: Smith Robert C. , Sershen Henry , Youssef Mary , Lajtha Abel , Jin Hua , Zhang Mumei , Chen Anmei , Guidotti Alessandro , Davis John M.
Published: March 2023

Introduction

People with schizophrenia have been reported to show deficits in tests of olfactory function. DNA methylation and GABAergic input have been implicated in biochemical processes controlling odor in animal studies, but this has not been investigated in human studies.

Methods

In a study of measures of DNA methylation and GABAergic mRNAs in lymphocytes, we also measured odor identification and discrimination with the Sniffin’ Sticks battery in 58 patients with chronic schizophrenia (CSZ) and 48 controls. mRNAs in lymphocytes were assessed by qPCR using TaqManTM probes. Cognition was assessed by the MATRICS battery (Measurement and Treatment Research to Improve Cognition in Schizophrenia) in CSZ and controls, and symptoms in CSZ were assessed by PANSS scale (Positive and Negative Symptom Scale). The relationships of odor deficits with mRNA, cognition, and symptoms were explored by correlation analysis. Variables which significantly differentiated CSZ from controls were explored by logistic regression.

Results

Overall, CSZ showed significantly (P≤.001) lower scores on odor discrimination compared to controls, with a moderate effect size, but no difference in odor identification. Deficits in odor discrimination, which has not been standardly assessed in many prior studies, strongly differentiated CSZ from controls. In logistic regression analysis, odor discrimination, but not odor identification, was a significant variable predicting schizophrenia versus control class membership. This is the first study to report relationship between odor deficits and DNA methylation and GABAergic mRNAs in blood cells of human subjects. There were negative correlations of odor identification with DNA methylation enzymes mRNAs and significant negative correlations with odor discrimination and GABAergic mRNAs. Lower odor scores were significantly associated with lower cognitive scores on the MATRICS battery in CSZ but not control subjects. In CSZ, lower odor scores were significantly associated with negative symptom scores, while higher odor identification scores were associated with PANNS Excitement factor.

Discussion

Odor discrimination was a more powerful variable than odor identification in discriminating CSZ from controls and should be used more regularly as an odor measure in studies of schizophrenia. The substantive meaning of the negative correlations of odor discrimination and GABAergic mRNA variables in peripheral lymphocytes of CSZ needs more investigation and comparison with results in neural tissue.
How do local government information sources affect the purchase willingness of low-carbon agricultural products? The example of regional brand agricultural products
Authors: Xu Pu , Wang Linlin , Li Yufeng , Liu Min
Published: March 2023

Introduction

In order to achieve the carbon peaking and carbon neutrality goals, the agricultural sector has been given high priority to reduce carbon emissions. Since consumption is the ultimate goal of production, the consumption of low-carbon agricultural products is of great significance to promote the reduction of agricultural carbon emissions. Regional brand agricultural product is an important tool to promote the development of regional economy to “green, low-carbon, branded and high-quality”, and has the technical and institutional conditions to develop into low-carbon agricultural product, so this study takes regional brand agricultural products as the representative of low-carbon agricultural products. As a information source to guide the public to consume in the green and low-carbon way, local government can effectively develop the market for low-carbon agricultural products and drive the development of low-carbon agriculture from the demand side.

Methods

Based on structural equation model with bootstrap method, this paper focuses on the mechanism of the influence of local government information source characteristics (credibility, professionalism, and attractiveness) on consumers' willingness to purchase low-carbon agricultural products, and explores the mediating role of perceived benefits and perceived risks.

Results

The following findings are established: first, the credibility and professionalism of local governments play a positive role in influencing the purchase willingness of low-carbon agricultural products through perceived benefits, with credibility having the greatest degree of influence. Second, the attractiveness of local governments positively influences consumers' willingness to purchase low-carbon agricultural products through perceived risk. Third, perceived benefits play a fully mediating role between credibility and purchase intention, play a partially mediating role between professionalism and purchase willingness, perceived risks play a partially mediating role between attractiveness and purchase willingness.

Discussion

This study provides new ideas for the construction of low-carbon agricultural products and low-carbon development in the agricultural sector from the perspective of local government information sources.
Very rapid insight generation to support UK health and care systems: An AHSN approach
Authors: Chandler Jackie , Darnton Philippa , Sibley Andrew
Published: March 2023

Introduction

COVID-19 challenges are well documented. Academic Health Science Networks (AHSNs) are a key partner to NHS and care organizations. In response to managing COVID-19 challenges, Wessex AHSN offered rapid insight generation and rapid evaluation to local NHS and care systems to capture learning during this period. This novel “Rapid Insight” approach involved one-off online deliberative events with stakeholders to generate insights linked to specific, priority areas of interest, followed by rapid analysis and dissemination of the findings.

Context

Key objectives were to enable system leaders to build their adaptive leadership capability and learn from the experience of COVID-19 to inform recovery planning and system support. Rapid Insight (RI) gathered together health and care professionals into a tightly managed, virtual forum to share system intelligence.

Approach

Focused questions asked about the systems' response to the pandemic, what changes to continue and sustain, or discontinue. Participants responded simultaneously to each question using the virtual chat function. Immediate thematic analysis of the chat conducted in 48–72 h by paired analysts for each question strengthened analytical integrity. Mind maps, the key output, provided easily assimilated information and showed linkages between themes. Telephone or virtual interviews of key informants (health and care professionals and patients) and routinely collected data were synthesized into short reports alongside several RI events. However, insufficient time limited the opportunities to engage diverse participants (e.g., mental health users). Data from RI can scope the problem and immediate system needs, to stimulate questions for future evaluative work.

Impact

RI facilitated a shared endeavor to discover “clues in the system” by including diverse opinions and experience across NHS and care organizations. Although these rapid virtual events saved on travel time, digital exclusion might constrain participation for some stakeholders which needs other ways to ensure inclusion. Successful rapid engagement required Wessex AHSN's existing system relationships to champion RI and facilitate participant recruitment. RI events “opened the door” to conversations between up to 150 multi-professional clinicians to share their collective response to COVID-19. This paper focuses on the RI approach with a case example and its further development.
Optimizing low-cost sampling of pollinator insects in oilseed rape fields
Authors: Shi Xiao-Yu , Orr Michael , Luo Arong , Wang Ming-Qiang , Guo Pengfei , Zhou Qing-Song , Niu Zeqing , Qiao Huijie , Zou Yi , Zhu Chao-Dong
Published: March 2023

Insects are key pollinators to ecosystem function, but much work remains to determine the most cost-effective, reliable scheme to monitor them. Pan traps (PT) and flight interception traps (FIT) are two of the most popular insect sampling methods used. However, their relative sampling performance and cost is poorly known for agroecosystems in China. We conducted a study across 18 oilseed rape fields in smallholder farmland in Zhejiang, China using these two traps. Our results showed that a single FIT had a greater sampling efficiency (more individuals and higher species richness) than a single PT, but controlling for cost, four PTs (the cost for four PTs is close to one FIT) showed a greater sampling efficiency than FITs. PTs collected more small-bodied individuals while FITs and PTs did not significantly differ in terms of monitoring pollinator insects with large body size. When exploring whether semi-natural habitat embedded in the agricultural landscape affected these results, results from both trap types shows that semi-natural habitat had a significant positive impact on wild pollinator diversity and rarefied species richness. Future studies that examine the effects of agricultural landscape on the wild pollinator community should combine PTs with netting or other active methods for long-term wild pollinator monitoring strategies.
Analytical and Numerical Results for the Transient Diffusion Equation with Diffusion Coefficient Depending on Both Space and Time
Authors: Saleh Mahmoud , Kovács Endre , Barna Imre Ferenc
Published: March 2023

The time-dependent diffusion equation is studied, where the diffusion coefficient itself depends simultaneously on space and time. First, a family of novel, nontrivial analytical solutions is constructed in one space dimension with the classical self-similar Ansatz. Then, the analytical solution for two different sets of parameters is reproduced by 18 explicit numerical methods. Fourteen of these time integrators are recent unconditionally stable algorithms, which are often much more efficient than the mainstream explicit methods. Finally, the adaptive time-step version of some of these algorithms are created and tested versus widespread algorithms, such as the Runge–Kutta–Fehlberg solver.