bluuebunny/crossref_metadata_2025 huggingface dataset:
Tick-borne infections of dogs in Serbia: A review of research
Authors: Potkonjak Aleksandar , Zekic-Stosic Marina
Published: December 2020

Increased prevalence of tick-borne disease in humans and animals is an important public health issue. Dogs can be clinically ill, reservoirs of tick-borne pathogens, or sentinel populations for research. Certainly, small-scale research has been conducted in dogs and this review will focus on the recent studies of emergent and re-emergent tick-borne pathogens in dogs in Serbia. Babesiosis stands out as the most common and important tick-borne disease in dogs. In addition to this pathogen, the presence of Hepatozoon canis and ?Candidatus Mycoplasma haematoparvum? in the blood of dogs was proved using molecular methods. Seroreactivity in dogs has been proven for Borrelia burgdorferi sensu lato (s.l.) complex, Ehrlichia canis, Ehrlichia ewingii, Anaplasma phagocytophilum, Anaplasma platys, Rickettsia conorii, and tick-borne encephalitis virus (TBEV). The presence of B. burgdorferi s.l. complex, A. phagocytophilum, Rickettsia spp. from the group of spotted fevers, and TBEV in ticks indicates the geographical distribution and potential for infecting humans, dogs, and other animals in Serbia. Further systematic, comprehensive, well designed, bacteriological, virological, parasitological, epidemiological, clinical (infectological), and acarological research is needed in Serbia.
Loss of Furin in β cells Induces an mTORC1-ATF4 Anabolic Pathway that Leads to β cell Dysfunction
Authors: Brouwers Bas , Coppola Ilaria , Vints Katlijn , Dislich Bastian , Jouvet Nathalie , Lommel Leentje Van , Segers Charlotte , Gounko Natalia V. , Thorrez Lieven , Schuit Frans , Lichtenthaler Stefan F. , Estall Jennifer L. , Declercq Jeroen , Ramos-Molina Bruno , Creemers John W.M.
Published: December 2020

FURIN is a proprotein convertase (PC) responsible for
proteolytic activation of a wide array of precursor proteins within the
secretory pathway. It maps to the PRC1 locus, a type 2 diabetes susceptibility
locus, yet its specific role in pancreatic β cells is largely unknown. The aim
of this study was to determine the role of FURIN in glucose homeostasis. We
show that FURIN is highly expressed
in human islets, while PCs that potentially could provide redundancy are
expressed at considerably lower levels. β cell-specific Furin knockout (βFurKO)
mice are glucose intolerant, due to smaller islets with lower insulin content
and abnormal dense core secretory granule morphology. mRNA expression analysis
and differential proteomics on βFurKO
islets revealed activation of Activating Transcription Factor 4 (ATF4), which
was mediated by mammalian target of rapamycin C1 (mTORC1). βFurKO cells show impaired cleavage or
shedding of the V-ATPase subunits Ac45 and prorenin receptor (PRR),
respectively, and impaired lysosomal acidification. Blocking the V-ATPase
pharmacologically in β cells increases mTORC1 activity, suggesting the
involvement of the V-ATPase proton pump in the phenotype. Taken together, these
results suggest a model of mTORC1-ATF4 hyperactivation and impaired lysosomal
acidification in β cells lacking Furin,
which causes β cell dysfunction.
Baseline Assessment of Circulating microRNAs Near Diagnosis of Type 1 Diabetes Predicts Future Stimulated Insulin Secretion
Authors: Snowhite Isaac , Pastori Ricardo , Sosenko Jay , Cayetano Shari Messinger , Pugliese Alberto
Published: December 2020

Type 1 diabetes is an autoimmune disease resulting
in severely impaired insulin secretion. We
investigated whether circulating microRNAs (miRNAs) are associated with residual
insulin secretion at diagnosis and predict the severity of its future decline. We
studied 53 newly diagnosed subjects enrolled in placebo groups of TrialNet
clinical trials. We measured serum levels of 2,083 miRNAs using RNAseq
technology, in fasting samples from the baseline visit (<100 days from
diagnosis), during which residual insulin secretion was measured with a mixed
meal tolerance test (MMTT). Area under the curve (AUC) C-peptide and peak
C-peptide were stratified by quartiles of expression of 31 miRNAs. After
adjustment for baseline C-peptide, age, BMI and sex, baseline levels of miR-3187-3p,
miR-4302, and the miRNA combination of miR-3187-3p/miR-103a-3p predicted
differences in MMTT C-peptide AUC/peak levels at the 12-month visit; the
combination miR-3187-3p/miR-4723-5p predicted proportions of subjects
above/below the 200 pmol/L clinical trial eligibility threshold at the 12-month
visit. Thus, miRNA assessment at
baseline identifies associations with C-peptide and stratifies subjects for future
severity of C-peptide loss after 1 year. We suggest that miRNAs may be useful
in predicting future C-peptide decline for improved subject stratification in
clinical trials.
SARS CoV-2 SPIKE GLYCOPROTEIN MUTATIONS AND CHANGES IN PROTEIN STRUCTURE
Authors: AKBULUT Ekrem
Published: December 2020

Severe Acute Respiratory Syndrome Corona Virus-2 (SARS CoV-2) is a single-stranded positive polarity RNA virus with a high virulence effect. Spike (S) glycoprotein is the outermost component of the SARS CoV-2 virion and is important in the entry of the virus into the cell via the angiotensin converting enzyme 2 (ACE2) receptor. ACE2 plays an important role in the regulation of human blood pressure by converting the vasoconstrictor angiotensin 2 to the vasodilator angiotensin 1-7. In this study, the changes that mutations in Asian isolates may cause in S glycoprotein structure were analyzed and modeled to contribute to drug and vaccine targeting studies. Genome, proteome and mutation analyses were done using bioinformatics tools (MAFFT, MegaX, PSIPRED, MolProbity, PyMoL). Protein modelling was performed using ProMod3. We detected 26 mutations in the S glycoprotein. The changes that these mutations reveal in the general topological and conformational structure of the S glycoprotein may affect the virulence features of SARS CoV-2. It was determined that mutations converted the receptor binding domain (RBD) from down-formation to like-up formation. It is thought that conformational change occurring after mutation in RBD may cause an increase in receptor affinity. These findings could be beneficial for disease prevention of and drug/vaccine development for SARS CoV-2.
The Lagrangian and Hamiltonian for RLC Circuit: Simple Case
Authors:   Department of Physics Education, Faculty of Teacher Training and Education, Sanata Dharma University, Panuluh AH
Published: December 2020

The Lagrangian and Hamiltonian for series RLC circuit has been formulated. We use the analogical concept of classical mechanics with electrical quantity. The analogy is as follow mass, position, spring constant, velocity, and damping constant corresponding with inductance, charge, the reciprocal of capacitance, electric current, and resistance respectively. We find the Lagrangian for the LC, RL, RC, and RLC circuit by using the analogy and find the kinetic and potential energy. First, we formulate the Lagrangian of the system. Second, we construct the Hamiltonian of the system by using the Legendre transformation of the Lagrangian. The results indicate that the Hamiltonian is the total energy of the system which means the equation of constraints is time independent. In addition, the Hamiltonian of overdamping and critical damping oscillation is distinguished by a certain factor.
Feasibility of Smartphone Camera Utilization and Power Point-based Video Analyzer on Kinematic Motion Experiment: An Inexpensive Method
Authors:   Department of Physics Education, Faculty of Teacher Training and Education, Sanata Dharma University, Atmajati ED , Salam RA ,   Department of Physics Engineering, School of Electrical Engineering, Telkom University
Published: December 2020

This study reports on the use of smartphone camera and power point application to analyze the kinematic motion experiment. This method is intended to make a better understanding of student’s concept using the tools that are commonly owned by students. The experiments performed in this study were one-dimensional (1-D) represented by falling motion and two-dimensional (2-D) using parabolic motion. In evaluating the experimental results, the obtained data were compared to the theoretical values that were calculated using analytical approach. The use of this method shows great measurement results in showing dependency of falling motion to gravitational acceleration and proofing the constant velocity at projectile motion on its horizontal plane in which it is comparable to the theoretical value. The video analyzation method also can be used as an alternative solution to the established software, even better when the higher resolution camera and frame rate was used. Noting that the tools used in the experiment were common tools around, thus, this can be used as a replacement for the advance tools.
Organizational and pedagogical conditions for the formation of future managers’ leadership competence with in the University Environment
Authors: Nestulya Svitlana
Published: December 2020

The leading role of effective managers, leaders, professionals, capable of rapid adaptation to the transformation and modernization processes in the current Ukrainian economy, politics, production, education and services is of particular importance in the context of the dynamic changes that are taking place in the contemporary socio-political, economic and educational space of Ukraine. Therefore, the problem of developing leadership competence of future managers in the university's educational environment arises. The purpose of the research is to substantiate organizational and pedagogical conditions for developing leadership competence of the future managers in the educational environment of universities and to outline the ways of their realisation. It has been found out that organizational and pedagogical conditions should be interpreted as fundamental grounds for combining actions facilitating the process of developing future managers’ leadership competence in the university's educational environment. It is necessary to consider them as well as to implement. The organizational and pedagogical conditions have been defined and substantiated: special training of the scientific and pedagogical tertiary staff in developing future managers’ leadership competence (round tables, workshops, trainings, etc.); enhancement of the process of developing future managers’ leadership competence through the implementation of distance learning in the university's educational environment (realized through the creation of a distance course "Fundamentals of Leadership"); implementation of the “kaizen” system in the educational environment of the university (implemented in the framework of the ongoing seminar-workshop "Kaizen Technology: the Path to Leadership").
Pedagogical culture of parents: challenges and ways of formation
Authors: Voronova Svitlana
Published: December 2020

The article considers the formation of parents’ pedagogical culture as an important factor in the development of general secondary education which ensures the quality of educational services. The analysis of the scientific and pedagogical literature, researches of the UNICEF and the National Children’s Hotline shows that the issue of forming parents’ pedagogical culture gains ground. According to the theory of generations, participants of the educational process belong to different age groups and there is a need to clarify the issue concerning how to establish their joint interaction to ensure the quality of education. Under such conditions, child’s parents must be pedagogically literate, be able to organise and implement effective family education, joint activities together with an educational institution to create an atmosphere of trust and mutual respect, where there is no violence or discrimination. The educational resource for parents is directly dependent on the level of their pedagogical culture formation as one of the components of their family life. Under parents’ pedagogical culture, we understand a system of pedagogical knowledge, pedagogical and psychological competence, which are aimed at the upbringing and development of a child. Moral, communicative, didactic, physical, aesthetic components; environmental culture and culture of thinking; speech, work, and moves are the components of parents’ pedagogical culture which are to be considered. The formation of parents’ pedagogical culture can be carried out by motivational, semantic and constructive components and is aimed at parents’ awareness of the need for pedagogical knowledge, their readiness to be an active participant in the education and upbringing process of the child. In the process of forming parents’ pedagogical culture, the teacher must constantly improve the skills of positive pedagogical communication, the validity of parents’ pedagogical position; introduce active forms of their learning; use the principles of partnership pedagogy and teamwork.
José María Tejado Sebastián (coord.), Vislumbrando la Tardoantigüedad. Una mirada desde la arqueología
Authors: Carrillo Rodríguez Miriam
Published: December 2020

Reseña de José María Tejado Sebastián (coord.), Vislumbrando la Tardoantigüedad. Una mirada desde la arqueología.
Adrián J. Sáez (ed.), Miguel de Cervantes. Información de Argel
Authors: Fernandes Alves da Silva Silvia Maria
Published: December 2020

Reseña de Adrián J. Sáez (ed.), Miguel de Cervantes. Información de Argel.
Juan Andrés, La literatura del siglo XVIII (edición, estudio y traducción de Davide Mombelli)
Authors: Calvo Landau José Luis
Published: December 2020

Reseña de Juan Andrés, La literatura del siglo XVIII (edición, estudio y traducción de Davide Mombelli).
Guadalupe Fernández Ariza (coord.), La ciudad como arquetipo. Literatura, historia y arte
Authors: Márquez Martín Carmen
Published: December 2020

Reseña de Guadalupe Fernández Ariza (coord.), La ciudad como arquetipo. Literatura, historia y arte.
Francisco Morales Lomas y Remedios Sánchez García, La poesía de Pablo García Baena
Authors: Aneri Alfonso
Published: December 2020

Reseña de Francisco Morales Lomas y Remedios Sánchez García, La poesía de Pablo García Baena.
Jorge Machín Lucas, José Ángel Valente: perfiles esotéricos
Authors: Martins-Frías Adriana
Published: December 2020

Reseña de Jorge Machín Lucas, José Ángel Valente: perfiles esotéricos.
Amando López Valero, Eduardo Encabo Fernández e Isabel Jerez Martínez, Didáctica de la lengua y la literatura en ESO. Innovación e investigación
Authors: Quiles Cabrera María del Carmen
Published: December 2020

Reseña de Amando López Valero, Eduardo Encabo Fernández e Isabel Jerez Martínez, Didáctica de la lengua y la literatura en ESO. Innovación e investigación.
En torno a algunas consecuencias de la interpretación heideggeriana de la mónada como representación en Leibniz
Authors: Neumann Soto Hardy Alberto
Published: December 2020

El presente artículo lleva a cabo una reflexión en torno a la interpretación que M. Heidegger efectuó de la idea de sustancia tal como la entendió Leibniz, vale decir, como mónada. Para llevar a cabo esta tarea se toma como texto base la lección de Marburgo del semestre de verano en 1928. Con vistas a identificar y evaluar las consecuencias de la interpretación heideggeriana, a la revisión interpretativa de la lección de 1928, se agregan explicaciones que complementan la exposición y discusión. Para ello se recurre, esta vez, a la lección que Heidegger dictó en el semestre de invierno 1935/19364 en la Universidad de Friburgo de Brisgovia.
Las reservas a los Tratados de Derechos Humanos en México: estado de la cuestión
Authors: PASTOR GARCÍA ALICIA MARÍA
Published: December 2020

En el presente artículo se plantea la importancia que tienen las reservas que formulan los Estados a los Convenios internacionales sobre Derechos Humanos y cómo esas reservas restringen las obligaciones asumidas por los Estados en este ámbito. En concreto, se trata de examinar la práctica convencional de México en materia de reservas, como medio para determinar la posición de este Estado respecto de la salvaguardia de los Derechos Humanos que se contienen en estos Tratados internacionales.
La transposición de la literatura y el teatro argentino del siglo XIX al cine del siglo XX: El último centauro o la epopeya de Juan Moreira de Enrique Queirolo
Authors: Noguera Lía Sabrina
Published: December 2020

A partir de la leyenda del gaucho argentino Juan Moreira, en el presente artículo nos proponemos analizar los diferentes atravesamientos artísticos que este cuerpo realiza desde fines del siglo XIX hasta principios del XX: de la novela a la arena del circo y del teatro al cine. Consideramos que en cada cruce y en cada nuevo soporte artístico el cuerpo de Moreira se resignifica y permite construir nuevas identificaciones con los contextos artístico, político y sociales que le son propio. A tales efectos, nos preocuparemos por el estudio de la novela, el drama y su transposición al cine a partir del filme realizado en 1924: El último centauro o la epopeya de Juan Moreira de Enrique Queirolo considerando para este análisis los aspectos constitutivos de la literatura, el teatro y el cine gauchesco.
Reescrituras en Soldados de Salamina o las sendas de la memoria: Desplazamientos de la literatura en el cine y en la narración figurativa
Authors: García Reyes David
Published: December 2020

El estudio realiza una búsqueda sobre las intersecciones que se producen producidas en el cine y en el cómic a partir de un texto fuente como Soldados de Salamina (2001) de Javier Cercas. Se abordan las prácticas reescriturales, los intersticios, las permutas y los cambios operacionales más destacados que se producen en el film Soldados de Salamina (2003) de David Trueba y en la novela gráfica Soldados de Salamina (2019) de José Pablo García. En los tres textos la memoria tiene un sentido y una representación distintas, pero los tres enfrentan el desarrollo de la trama como una indagación autónoma y se produce un diálogo que enriquece las reflexiones que se derivan del conjunto de cada una de las manifestaciones, estimulando el debate que propicia los diferentes puntos de vista y el enfoque de los tres objetos de estudio analizados.
Certain Considerations Regarding the Attributions of the Romanian Guardianship Court in the Protection of the Minors
Authors: Creț Daniela Cristina
Published: December 2020

The minors’ vulnerability led to the adoption of certain special means of protection. Among them, special protection measures and adoption play a special role. This paper analyses the Romanian court attributions, as guardianship court in the matter of these measures which are regulated by the dispositions of the Law no. 272/2004 republished, regarding the protection and promotion of children's rights and of the Law no. 273/2004 on the procedure of adoption, and it is intended to continue the paper on the same topic from the previous issue.
Paranasal sinus mucoceles, therapeutic solution through external surgical approach
Authors: Cobzeanu Bogdan Mihail , Palade Dragos Octavian , Bandol Gianina , Vonica Patricia Sonia , Severin Florentina , Moisii Liliana , Cobzeanu Maria Luiza , Apostol Delia Ciobanu , Matei Daniela Viorelia , Cobzeanu Mihail Dan
Published: December 2020

Mucoceles are benign, expansive, cystic tumors, affecting especially the adult, with development in the paranasal sinuses. Clinical symptoms are not specific. These are rare conditions that originate within the sinusal mucosa, favoured by the obstruction of the sinus ostium. Due to the inflammation and the expansive character of the tumor, with the erosion of the bony walls, combined forms can develop, with the involvement of two or more sinuses, most frequently with fronto-ethmoidal localization.

The authors carry out a clinical retrospective study on 25 cases of mucoceles of the paranasal sinuses, diagnosed and treated in the ENT Clinic of the “Sfantul Spiridon” Emergency Clinical Hospital Iasi, during 2015-2019. The authors insist on aspects related to clinical and radiological diagnosis (CT scanner), as well as surgical treatment by external approach.

The postoperative evolution is generally simple, with full recovery, without complications or recurrences.

The diagnosis of the mucoceles of the paranasal sinuses consists in radiologic techniques by preoperative CT scan examination, intraoperative macroscopic aspect and histopathological result.

Surgical approach with complete excision of the tumor and creating a new sinusal drainage path prevents the occurrence of recurrences.
GPS-DERIVED SECULAR VELOCITY FIELD AROUND SANGIHE ISLAND AND ITS IMPLICATION TO THE MOLUCCA SEA SEISMICITY
Authors: Heliani Leni Sophia , Pratama Cecep , Parseno Parseno , Widjajanti Nurrohmat , Lestari Dwi
Published: December 2020

Sangihe-Moluccas region is the most active seismicity in Indonesia. Between 2015 to 2018 there is four M6 class earthquake occurred close to the Sangihe-Moluccas region. These seismic active regions representing active deformation which is recorded on installed GPS for both campaign and continuous station. However, the origin of those frequent earthquakes has not been well understood especially related to GPS-derived secular motion. Therefore, we intend to estimate the secular motion inside and around Sangihe island. On the other hand, we also evaluate the effect of seismicity on GPS sites. Since our GPS data were conducted on yearly basis, we used an empirical global model of surface displacement due to coseismic activity. We calculate the offset that may be contained in the GPS site during its period. We remove the offset and estimate again the secular motion using linear least square. Hence, in comparison with the secular motion without considering the seismicity, we observe small change but systematically shifting the motion. We concluded the seismicity in the Molucca sea from 2015 to 2018 systematically change the secular motion around Sangihe Island at the sub-mm level. Finally, we obtained the secular motion toward each other between the east and west side within 1 to 5.5 cm/year displacement.
Interpretacyjna Analiza Fenomenologiczna w badaniach jakościowych w psychologii...Przegląd najnowszych badań
Authors: Rudnik Agata , Bieńkowski Jakub
Published: December 2020

Interpretacyjna Analiza Fenomenologiczna (IPA) jest metodą badań jakościowych

skupiającą się na zrozumieniu, w jaki sposób ludzie nadają sens swoim przeżyciom

i doświadczeniom. Po raz pierwszy opisana przez Jonathana Smitha w 1996 r, obecnie

znacznie zyskuje na popularności znajdując zastosowanie w psychologii klinicznej,

psychoterapii czy psychoonkologii. W artykule dokonano przeglądu najnowszych badań

opartych na IPA z wyszczególnieniem ich tematyki, źródeł, autorów i liczby uczestników.

Pokazano także rosnącą z roku na rok liczbę publikacji wykorzystujących interpretacyjną

analizę fenomenologiczną. Artykuł ukazuje możliwe zastosowania IPA w badaniach

psychologicznych iudowadnia, że metodologia ta pozwala na zebranie unikatowych

danych niemożliwych do pozyskania w klasycznych badaniach ilościowych.
Sixteen new records for the flora of Lebanon
Authors: Addam Khodr , Bou-Hamdan Mounir , Sabbagh Nisreen
Published: December 2020

Significant new species that belong to diverse genera and families were recorded to exist in Lebanon during our continuous non-stop field survey all over the country. The authors gathered some exceptional taxa from distinctive locations and habitats of the country, which were not reported so far in the flora documentation with the exception of Quercus libani, that is regarded as a very atypical species (for Lebanon) discovered for the first time after Post in 1932. The current paper deals with the records Anchusa milleri Lam. ex Spreng, Bassia hyssopifolia (Pall.) Kuntze., Eminium heterophyllum (Blume) Schott., Euphorbia prostrata Aiton, Euphorbia serpens Kunth, Hypericum olivieri (Spach) Boiss., Kickxia cirrhosa (L.) Fritsch., Lamium macrodon Boiss. & A.Huet,  Onosma fruticosum Sm.lder, Plantago crypsoides Boiss., Platanthera holmboei H.Lindb.,  Potamogeton perfoliatus L.,  Quercus libani G.Olivier, Rhamnus kurdica Boiss. & Hohen., Tulipa biflora Pall. and Xanthium strumarium subsp. sibiricum (Patrin ex Widder) Greuter. The plants were photographed, collected, dried and herbarium specimens were prepared and deposited in K. Addam's Herbarium AUL University (Lebanon). Their taxonomical and ecological characters as well as their geographical distributions were exhibited. New Taxa (representing 14 genera in 12 families of flowering plants) were recognized with the reference of different floras and recent literature for their authentication. The present study also files them with updated nomenclature, descriptions, and notes on phenology and images for their easy identity.
Blood glucose regulating hormones and their physiological and biochemical roles
Authors: Mujtahid Maqsuduulah
Published: December 2020

Regulation and coordination of different body organs is important in multicellular organisms. Hormones and the nervous system participate in this synchronization. Hormones are the compounds and chemical messengers produced by cells, glands, or special tissues called the endocrine system and released into the bloodstream. In addition to the hormones, blood is consist of proteins, sugars, lipids, vitamins, etc. Blood sugar is glucose which produces energy in the body. Regular blood glucose levels vary at different ages and exceed 120-170 mg / dl. It is harmful and even fatal to increase or decrease it from the normal level, so the concentration of glucose dissolved in plasma was subject to tight regulation and various regulatory mechanisms were developed thereon. Hormones cortisol, glucagon, adrenaline, and glucocorticoids are the major regulators. These substances are tracked regularly to prevent blood glucose from rising and dropping. Insulin consists of hyperglycemia, as well as other hormones. The mechanism by which it affects the metabolism of the food (carbohydrates, lipids, proteins) prevents hypoglycemia in several respects.
ANALISIS KEBIJAKAN PEMERINTAH TERKAIT PENGATURAN HARGA TIKET PESAWAT DI INDONESIA
Authors: Yuniza Mailinda Eka , Jibril Muhammad , Rebecca Aicha Grade
Published: December 2020

Deregulation made by Government Regulation No. 40 of 1995 has intensified the competition in the aviation industry. As time passes by, many airlines implement the Low-Cost Carrier (LCC) concept. The negative effect of these LCC is that aviation companies compete to lower their prices, thus neglecting the safety factor. This research method employed in this research is normative research, whereas the material used is secondary data. The result of this research indicates that airplane ticket prices, especially economy class, are regulated in Ministry of Transportation Decree Number KM 106 of 2019 about The Upper Limit Tariff for Passengers in Economy Class Services for Scheduled Domestic Commercial Air Transport. On the other hand, this ministerial decree has not been able to solve the issues that arise in our society. Authors think that airplane ticket price as one of the essential production branches for the country needs to regulated thoroughly in order to achieve the greatest prosperity of the people in accordance with Article 33 of the 1945 Constitution.
Pengaruh Pelayanan dan Fasilitas Digital Terhadap Kepuasan Penumpang di Bandara Internasional Kualanamu
Authors: Putra Ok Yoga Syah , Sihombing Sarinah , Tasran Chaidir
Published: December 2020

Tujuan dari penelitian ini untuk mengetahui pengaruh dari pelayanan dan fasilitas digital terhadap kepuasan penumpang di Bandara Internasional Kualanamu, Medan. Penelitian ini menggunakan metode kuantitatif dengan menyebarkan kuesioner kepada 100 sampel penumpang keberangkatan domestik Bandara Internasional Kualanamu. Hasil penelitian menunjukan adanya hubungan yang sangat kuat antara pelayanan dan fasilitas digital terhadap kepuasan penumpang. Nilai dari kontribusi variabel pelayanan dan fasilitas digital sebesar 77,1% mempengaruhi kepuasan penumpang di Bandara Internasional Kualanamu, Medan.
Analisa Kesepakatan ASEAN Open Skies Terhadap Lalu Lintas Penumpang dan Pesawat di Asia Tenggara
Authors: Sembiring Benny Lala
Published: December 2020

Sektor transportasi udara merupakan salah satu faktor penting dalam mendukung kegiatan perekonomian di suatu negara. untuk mencapai hal tersebut negara-negara yang tergabung di dalam ASEAN (Association of South East Asian Nation) sepakat untuk menjalankan kebijakan liberalisasi transportasi udara atau lebih dikenal dengan ASEAN Single Aviation Market (ASAM) atau ASEAN Open Skies. Tujuan dari kebijakan tersebut adalah meliberalisasi akses pasar dengan mengendurkan hambatan kebebasan transportasi udara (freedom of air) yang ke-3, ke-4 dan ke-5 antar negara-negara anggota ASEAN. Studi ini secara spesifik bertujuan untuk menghitung akibat dari kesepakatan ASEAN Single Aviation Market terhadap volume penumpang internasional dan maskapai penerbangan (low-cost carrier/LCC dan full-service carrier/FSC). Studi ini menggunakan data lalu lintas penumpang dan pesawat yang diperoleh dari OAG (official airline guide) yaitu data lalu lintas udara dengan rute kedatangan dan keberangkatan 30 bandara utama internasional di Asia Timur dan Asia Tenggara, pada periode waktu tahun 2010, 2015 dan 2017). Metode penelitian yang digunakan pada studi ini menggunakan DID (Difference in Differences) fixed effects, dengan jumlah observasi sebanyak 232,437 OD city pair (Origin-destination city pair). Hasil dari studi menunjukkan bahwa kesepakatan ASEAN Open Skies berdampak positif terhadap lalu lintas penumpang dan pesawat, yaitu total penumpang internasional, penumpang LCC, maskapai LCC, dan maskapai FSC pada rute antar-kota di Asia Tenggara, baik rute kedatangan maupun keberangkatan. Hasil dari penelitian ini diharapkan dapat menambah literatur yang terkait dengan industri penerbangan khususnya tentang liberalisasi transportasi udara.
The implementation of the differentiation of access rights in the "Portfolio SibGIU" information system
Authors: Raeckiy Alexandr , Shlyanin Sergey , Ermakova Liudmila
Published: December 2020

The object of the study is the information system for the formation of the student's electronic portfolio. The subject of the research is the organization of the differentiation of access rights for different groups of users: students, portfolio moderators and administrators. The rights, functions and interface of each user group of the information system are considered in detail. A mechanism is described that allows the Siberian State Industrial University Portfolio information system to define a new right for LMS Moodle, which gives the Moodle user the ability to view all categories of files in the portfolio, as well as a report on the group's activities. When creating an information system, the deduction method was used, in which, for a variety of particular features, a conclusion was made about the total population of the features studied, as well as a method for analyzing the existing 4portfolio software. The main result of the work is the implementation of differentiation of access rights in the information system “Siberian State Industrial University Portfolio”, due to which the plugin defines three roles: the user, the moderator of the portfolio and the administrator. The users are university students who can upload documents to the portfolio confirming personal achievements in various activities, and each of their actions is controlled by a moderator assigned to the group, which improves the quality of filling and avoids errors in the formation of the portfolio. To control the process of filling the portfolio in the information system "Siberian State Industrial University Portfolio" reports of various levels of detail are generated, reflecting the results of the work of both moderators and users. To realize the possibility of viewing the contents of a student portfolio by registered users of LMS Moodle, the Siberian State Industrial University Portfolio information system defines a new right in LMS Moodle.
Software Reliability definition in the modern information system structure
Authors: Ponachugin Aleksandr Viktorovich
Published: December 2020

The subject of research is the use of modern approaches to determine aimed at improving the reliability of software security and quality of the information system. The object of research is a model determining the reliability of the software. The author examines in detail aspects such topics as: the use of a functional approach to the study of the reliability of the software component is the sum of the aggregate reliability to achieve each function block; Use a systematic approach to the study of the reliability of the software in the information system structure. Particular attention is paid to the comparison of existing models and methods of determining the reliability. The proposed method of estimating software reliability based on the allocation of the function blocks and to guarantee quality and reliability of the final result of software development. Key findings of the study: the use of a systematic approach makes it possible to identify the quality of the following interconnections between the constituent elements of the program, which define modern ways to improve software reliability. The paper proposed to adapt the major principles of the system improve the reliability of software proved useful effect of their introduction. The novelty of the research lies in the joint use of the functional and systemic approach in order to identify ways to increase the quality and reliability that takes into account the characteristics within the structural elements of the program and their interaction.
The generalized centrality method for analyzing network cyberspace
Authors: Gorlushkina Natalia Nikolaevna , Ivanov Sergei Evgenievich , Ivanova Lubov Nikolaevna
Published: December 2020

The subject of the research is the methods of network cyberspace analysis based on graph models. The analysis allows to find leaders of groups and communities, to find cohesive groups and visualize the results. The main methods of the graph theory used for cyberspace social networks are the methods of analyzing the centrality to determine the relative weight or importance of the vertices of the graph. There are known methods for analyzing centralities: by degree, by proximity, by mediation, by radiality, by eccentricity, by status, eigenvector, referential ranking. The disadvantage of these methods is that they are based only on one or several properties of the network participant. Based on the centrality analysis methods, a new generalized centrality method is proposed, taking into account such participant properties as the participant's popularity, the importance and speed of information dissemination in the cyberspace network. A mathematical model of a new method of generalized centrality has been developed. Comparison of the results of the presented method with the methods of the analysis of centralities is performed. As a visual example, a subgroup of cyberspace consisting of twenty participants, represented by a graph model, is analyzed. Comparative analysis showed the accuracy of the method of generalized centrality, taking into account at once a number of factors and properties of the network participant.
Familial adenomatous colorectal polyposis complicated by colonic obturation: a clinical case
Authors: Durleshter V. M. , Kryachko A. A. , Chuguzov K. D. , Tarlanova M. K.
Published: December 2020

Background. Colorectal obturation is a fairly rare complication in patients with colorectal polyposis. Case descriptions of colonic obturation with underlying familial adenomatous colorectal polyposis have not been reported to date in national and foreign literature.

Clinical Case Description. Patient G., female, 31 yo, was emergently admitted to a surgical unit with a preliminary diagnosis: acute intestinal obstruction, complaints of abdominal pain, nausea, vomiting, stool and gas outlet blockage, marked general weakness. Clinical and biochemical blood tests without peculiarities. Signs of intestinal obstruction in abdominal ultrasonic and X-ray examination. Obstructive right hemicolectomy performed as emergent surgery. Diagnosis: transverse colonic C-r T3NoMo, stage II, clinical group 2. Patient had routine ﬁbrocolonoscopy in six months; polyps were revealed in all operated colon portions. APC genetic test was positive, total colectomy was decided with single-barrel ileostomy excretion on anterior abdominal wall. Deﬁnitive diagnosis: transverse colonic C-r T3NoMo, stage II, developed with underlying familial adenomatous colorectal polyposis, clinical group 2.

Conclusion. Diagnosis of familial adenomatous colorectal polyposis with acute intestinal obturation is challenging due to forced urgent surgical intervention and lack of time for a detailed deeper examination in avoidance of baleful consequences. The case reported demonstrates that clinical manifestations of familial adenomatous colorectal polyposis extend beyond the routine complaints of abdominal bloating, stool blockage and rectal bleeding towards a formidable complication of acute colonic obturation of polypoid genesis.
Impact of Vaginal Microbiota on Gestation and Labour
Authors: Karakhalis L. Yu. , Ivantsiv N. S.
Published: December 2020

Background. Imbalances of vagina microbiota in pregnant women entail the development of bacterial vaginosis and candidal vulvovaginitis. Lactobacterial strains modulate pro-inﬂammatory epithelium responses to enhance resistance, which renders lactobacteria promising agents in pregnant women with elevated pH.

Objectives. Assessment of the lactobacterial impact on vaginal microbiota and the course of gestation and labour.

Methods. A total of 261 pregnant women were examined and separated by cohorts according to pH of vaginal ﬂuid: ≥4.5 in cohort 1 (n = 147), <4.5 in cohort 2 (n = 114). Cohort 1 had age 29.9 (4.6) years, cohort 2 — 29.0 (4.6) years, p = 0.55. Screening: at weeks 11–14, 18–21, 30–34 and 36–41 of gestation we performed vaginal pH-metry, cervicometry, determined opportunistic pathogens and lactobacteria with mass spectrometry. Cohort 1 received lactobacteria. Statistical analyses were performed with Statistica 10.

Results. In cohort 1 receiving lactobacteria, the number of women devoid of opportunistic ﬂora increased from 31.29 to 43.53%. In cohort 2 not receiving lactobacteria, this number decreased from 53.51 to 35.09%. In cohort 1, L. jensenii (correlates with bacterial vaginosis rate) was primarily isolated in 9.52% women, and in 14.91% — in cohort 2. The rate of L. jensenii increased to 14.96% in cohort 1 (receiving lactobacteria) and decreased to 3.51% in cohort 2 (not receiving lactobacteria). A higher L. jensenii rate correlated with absent growth of opportunistic pathogens. Increasing the rate of L. crispatus (suppresses opportunistic pathogens) to 14.96% in cohort 1 lead to a 1.9-fold diminishing of active opportunistic ﬂora. An increase of L. crispatus from 7.02 to 30.7% in cohort 2 supressed active opportunistic growth 3.9-fold at a normal baseline pH. Cervicometry values were invariant between the cohorts. Pregnancy complications were not observed under abundant lactobacterial growth. The risk of gestation loss occurred in 1.4% of women in cohort 1 and in 10.5% — in cohort 2. Abnormal labour and premature rupture of foetal membranes were more frequent in cohort 2.

Conclusion. With a less favourable premorbid condition in cohort 1, vaginal changes with background lactobacterial therapy facilitate gestational health in pregnancy. Many “sterile” niches, especially the maternal generative passages, represent active low biomass environments inhabited by unique typical maternal microﬂora. Most remarkable is the correlation between health of vaginal microbiota and abnormal labour.
Qualidade de vida de pacientes em terapia renal substitutiva: uma análise da doença renal crônica e perfil populacional de risco
Authors: Fernandes Daniela , Zanelli Tauane Letícia Pinto , Rodrigues Aline Scharr , Rodrigues Mariana Paula , Lodi Jucilene Casati , Marques Tatiane Montelatto , Dos Reis Gislene , Ferreira Luciane Ruiz Carmona , Milagres Clarice Santana
Published: December 2020

Objetivos: Avaliar a qualidade de vida de pacientes portadores de Doença Renal Crônica (DRC) em Terapia Renal Substitutiva (TRS), modalidade de hemodiálise, identificando os componentes e seus respectivos domínios comprometidos.  Métodos: Estudo transversal, prospectivo, descritivo com abordagem quantitativa com portadores de DRC em TRS há no mínimo três meses, em uma instituição de saúde, interior do Estado de São Paulo. A coleta de dados foi realizada com 109 pacientes e utilizou-se os questionários sociodemográfico e de saúde; e o instrumento Avaliação da Qualidade de Vida (SF-36). Os dados foram analisados utilizando-se média, mediana e desvio padrão. Resultados: Dos sujeitos adultos participantes, 60% apresentaram um comprometimento na qualidade de vida relacionada as limitações físicas. Na estratificação os pacientes com condições clínicas comprometidas em início de tratamento sem acesso vascular definitivo, foi verificado comprometimento em variáveis físico e mental. Conclusão: Concluímos que a DRC causa impacto nos diferentes domínios dos compenentes físico e mental nos pacientes em tratamento hemodialítico. Tais comprometimentos podem implicar em significativo impacto, desempenho e percepção destes indivíduos sobre suas QV frente à doença e seu tratamento, um acompanhamento e monitoramento da equipe multidisciplinar.
Tumor neuroendócrino de apêndice: estudo de caso
Authors: Cangussu Igor Vitoi , Ferraz Edna Delabio , Mello Luiz Felipe Costa , De Oliveira Cristina Pimont , De Castro Leatrice Schubert Guilhon , Junqueira Thaís Bandeira de Oliveira , Reis Thais Rezende , Batista Arthur Valdier , Vicente Lucas Machado de Souza , Carvalho Ana Luíza de Castro
Published: December 2020

Objetivo: Este artigo visa relatar um caso em que houve diagnóstico acidental de tumor neuroendócrino do apêndice no decorrer de investigação tomográfica de cálculo renal. Detalhamento do caso: Mulher, 62 anos, com diagnóstico acidental, em tomografia computadorizada, de tumoração em apêndice cecal sendo submetida a apendicectomia videolaparoscópica com diagnóstico anatomopatológico (AP) e imuno-histoquímico de tumor neuroendócrino de 2,5 x 1,5 cm, infiltrando gordura adjacente, com infiltração perineural, positivo para cromogranina e índice proliferativo pelo Ki67 < 2%. Devido ao achado do AP a paciente foi submetida à hemicolectomia direita. A paciente em questão permaneceu em acompanhamento por 2 anos, sendo realizado nesse período tomografia computadorizada seriada anualmente; em seu último controle no ambulatório foi orientada e liberada do acompanhamento, com cura do quadro. Considerações Finais: Os tumores neuroendócrinos do apêndice são neoplasias raras, geralmente com bom prognóstico. Seu diagnóstico e tratamento devem ser baseados no laudo histopatológico e imuno-histoquímico. Em casos selecionados, está indicada a hemicolectomia direita.
The effect of ozone injection within a common peroneal nerve schwannoma: A mistreatment due to a misdiagnosis
Authors: Vetrano Ignazio Gaspare , Acerbi Francesco , Marucci Gianluca , Nazzi Vittoria
Published: December 2020

Background:

Peripheral schwannomas can be misdiagnosed or mistreated as they can mimic other subcutaneous lesions, leading to wrong diagnosis and, therefore, to improper treatment.

Case Description:

A 23-years-old male presented a painful growing nodule at the left popliteal fossa, with distally irradiated pain. A first magnetic resonance imaging depicted a heterogeneous lesion between common peroneal and sural nerves but, surprisingly, the patient was submitted to perilesional injection of ozone-oxygen mixture, causing the onset of intense neuropathic pain. A second MRI showed a morphological change of tumor characteristics. He finally underwent surgery but, intraoperatively, inter-fascicular fibrous adherences were noticed, making the tumor removal more difficult and riskier. The histopathological diagnosis was of schwannoma with areas of foreign body reaction.

Conclusion:

The injection of ozone or other substances within a subcutaneous swelling should be avoided, before a complete imaging assessment; because of such swelling could be a peripheral nerve schwannoma. The correct assessment of a lesion of the limbs determining radiating pain should be carefully demanded to a thorough history, clinical examination, and appropriate imaging technique. To avoid incorrect management, the treatment of such tumors should be performed in the first place by dedicated equips with proven expertise in this field.
Pemetaan Implementasi Kebijakan Sistim Informasi Desa Di Kabupaten Kuantan Singingi
Authors: Saputra Trio , Eka Eka , Sufi Wasiah
Published: December 2020

Penelitian ini bertujuan untuk melakukan pemetaan implementasi kebijakan sistim informasi desa yang ada di kabupaten kuantan singing. Metode yang digunakan dalam penelitian ini adalah diskriptif kualitatif data bersumber dari data skunder dan primer analisis data menggunakan interaktif model. Hasil penelitian menunjukkan implemntasi kebijakan sistim informasi desa belum maksimal di kabupaten kuantan singingi yang terdapat 218 desa  yang menerapkan sistim informasi desa di kabupaten kuantan singing hanya berjumlah 183 desa. Hal ini menunjukkan upaya yang dilakukan implementor kebijakan belum maksimal kepada pemerintah desa serta fasilitator belum melakukan pendampingan secara maksimal.
Care Stick dan Core Paddle: Media Pembelajaran Pendidikan Jasmani Adaptif Untuk Siswa Disabilitas
Authors: Hidayatullah Fajar , Anwar Khoirul , Ruski
Published: December 2020

The development of this sports learning media in the form of a relay baton and table tennis bat to solve the problem of motion learning for students at State Special School Keleyen. It is safe learning media because it will be used by students who are often hyperactive, it is comfortable to use for students with physical disabilities and to attract students’ attention with students’ uniqueness. The development research method uses a descriptive quantitative approach applied with adjustments to the COVID-19 pandemic condition so that numbers of samples do not enable with large amount and are made separately to maintain the health and safety of all related parties in it. The sampling technique uses purposive sampling with details of a total of 60 samples divided in 3 development stages and descriptive analysis is conducted to conclude the development result. The research results shows the form of a relay stick with the safe characteristics, it is comfortable to use and attracting attention have been reached supported by the majority of respondents that give positive responses to the results of the development of the CARE Stick can be accepted well as a modified relay stick based on the needs of Keleyan Special School students. Likewise, the CORE Paddle is as a modification of table tennis bat that can be accepted well as a result of development that can fulfill the needs of Keleyan State School students.
Kepemilikan Amanah Dalam Islam
Authors: Ulhaq M. Zia
Published: December 2020

Kepemilikan adalah suatu ikatan seseorang dengan hak miliknya yang disahkan syariah. Kepemilikan berarti pula hak khusus yang didapatkan si pemilik sehingga mempunyai hal menggunakan sejauh tidak melakukan pelanggaran pada garis-garis syariah. Penelitian ini fokus mengkaji mengenai bagaimana kepemilikan harta dalam Al-Qur’an dan Hadis. Metode tafsir yang digunakan adalah metode maudhu’I. Hasil penelitian adalah bahwa  kepemilikan mutlak yaitu Allah SWT dan manusia sebagai perantara untuk menjaga dan memakmurkan bumi untuk kehidupan manusia. Dengan demikian, kepemilikan harta ini merupakan sarana untuk kehidupan manusia untuk menjaga amanah yang telah dberikan dan dipergunakan sebak-baiknya bagi kebahagiaan didunia maupun diakhirat dan juga kemaslahatan umat manusia agar dalam menjalani kehidupan yang lebih baik.