bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Risk Factors for Diarrhea: The Effectiveness of Poskestren Programme in Islamic Boarding School, Lamongan
Authors: Lestari Marselli Widya , Masithah Dewi
Published: February 2025

Diarrhea is one of the most common infectious diseases. A survey of students in Islamic boarding schools showed that 9 out of 10 students experience diarrhea every month. This can be caused by several factors, such as environment, sanitation, lack of knowledge, etc. Furthermore, the main factor in the spread of diarrhea is poor sanitation habits. This research will be able to answer the causes of diarrhea incidence in Islamic Boarding Schools, especially in Mazro'atul Fattah Al-Maliky Islamic Boarding School, Lamongan. This research is an analytical descriptive which uses primary data in the form of questionnaires. The independent variables studied were behavioral factors (hand washing and nail hygiene), environmental factors (latrines and clean water), other factors (knowledge, food, drink and psychological), while the dependent variable was the incidence of diarrhea. The result is behavioral and environmental factors are partially related to the incidence of diarrhea in students of the Mazro'atul Fattah Al-Maliky Islamic Boarding School which has a significance value of both (p < 0.05). Otherwise, knowledge, eating and drinking, and psychological factors have no influence on the incidence of diarrhea.  Keeping the environment clean and implementing good sanitation behaviour is very important in preventing the spread of diarrheal diseases. Therefore, it is necessary to support and develop the poskestren programme on clean and healthy living behaviour in Islamic boarding schools.
Literature Review Kebisingan, Dampaknya pada Kesehatan dan Masa Depan Teknologi Aerodinamika Pesawat
Authors: Hamdiyati Rachmy , Wibawanti Retno
Published: February 2025

Noise is an environmental problem that is difficult to avoid in today's modern era. One of the sources of the noise is generated by the aviation industry. Noise pollution requires special attention because of its impact on human health. The existence of standards and regulations regarding noise in aviation and advances in aircraft aerodynamics technology will reduce noise in the aviation industry.This literature review focused on noise, the process of noise occurrence in aircraft aerodynamics, its impact on human health, and how changes in the future of aircraft aerodynamics to reduce noise.
The Potency of Curcuma domestica Val./Curcuma longa Linn. Active Compounds in Treating Hyperuricemia and Its Complications: A Literature Review
Authors: Syafitri Bq. Annisa Salmaadani , Amany Zhafirah , Karlina Fairuz , Ramadhita Nova Izza Salsa , Zakiyyah Luthfi , Ayunda Rahmah Dara , Kamilah Nilam Nurmilatun , Ilham M. Arya Rifqi
Published: February 2025

Background: Hyperuricemia is condition when the level of blood uric acid exceeds 6 mg/dL in women and 7 mg/dL in men. This can be caused by increase in uric acid production, decrease in uric acid excretion, or combination of both. Although often asymptomatic, hyperuricemia can lead to complications such as gout arthritis, gout nephropathy and kidney stones. It also exacerbates comorbidities like chronic kidney disease, cardiovascular disease and diabetes. Pharmacological treatments that are often used include disease-modifying antirheumatic drugs (DMARDs). However, DMARDs frequently cause side effects. Turmeric (Curcuma domestica Val./Curcuma longa Linn.) contains potential active compounds to be developed into new drugs for hyperuricemia.
Objective: This literature study aims to investigate potency of Curcuma domestica Val./Curcuma longa Linn. active compounds in treating hyperuricemia and its complications.
Method: This article is a literature review, using reference sources from previous research journals.
Results: Active compounds in turmeric, specifically curcumin, can lower uric acid levels through various mechanisms, including the reduction of urate transporter 1 (URAT1) and inhibition of xanthine oxidase (XOD) activity. Curcumin also inhibits NLRP3-dependent caspase1 activation, reduces IL-1B secretion and exhibits nephroprotective properties by modulating gut microbiota, which helps prevent progressive kidney damage in patients with hyperuricemia. Additionally, this research shows that other active compounds in turmeric have potency in treating hyperuricemia complications by targeting protein processing in the endoplasmic reticulum.
Conclusion: Turmeric contains various active compounds which are potential to treat hyperuricemia and its complications. 
 
Keywords: Curcumin, Curcuma longa Linn., Curcuma domestica Val., Hyperuricemia, Uric Acid, Traditional Medicine, Curcuminoid
Pemanfaatan Senyawa Flavonoid sebagai Antioksidan pada Penderita Hiperkolesterolemia: Studi Literatur
Authors: Ayunda Rahmah Dara , Malita Soufa
Published: February 2025

Hypercholesterolemia is a condition characterized by abnormal lipid profiles in the blood, including total cholesterol, low-density lipoprotein (LDL), and triglycerides. Hypercholesterolemia can trigger oxidative stress, which may lead to several chronic diseases, such as atherosclerosis, cardiovascular disease, stroke, and type 2 diabetes mellitus. The utilization of active compounds from plants, commonly found in Indonesian communities, is believed to provide positive effects on hypercholesterolemia. Active compounds like flavonoids, according to several studies, can act as antioxidants in suppressing the rate of oxidative stress. Oxidative stress is one of the major risk factors for hypercholesterolemia. The purpose of this literature review is to examine the mechanisms of flavonoid compounds as antioxidants in the treatment of hypercholesterolemia. This review was compiled by gathering articles from Google Scholar, Science Direct, Proquest, and Pubmed. The extracted data were analyzed to summarize findings related to the effects of flavonoid active compounds on hypercholesterolemia.
Flavonoid active compounds that can be isolated from plants have various positive effects on hypercholesterolemia. These positive effects may occur through various mechanisms, including acting as antioxidants to prevent oxidative stress, helping to increase levels of antioxidant enzymes, and regulating the expression of antioxidant genes such as SOD, CAT, and GSHPx. Flavonoids can also inhibit HMG-CoA reductase and enhance LDL receptors involved in cholesterol synthesis and transport. Flavonoids may also affect cholesterol efflux capacity in macrophages by inhibiting SR-A and CD36 receptors, while increasing ABCA1, ABCG1, and SR-B1. Flavonoids are compounds with potential in preventing and treating hypercholesterolemia through various mechanisms. The active mechanisms of flavonoids can influence the metabolic and genetic aspects of hypercholesterolemia patients.
Keywords: Hypercholesterolemia, Flavonoids, Antioxidants, Oxidative Stress.
Vasopresin and Corticosteroid use in Septic Shock : A Review
Authors: Putri Baiq Auliya Cahya , Silvi Sari Dewi  , Atika Soleha  , Dela Serlina  , Baiq Wanda Anisa  , Salman Elwaro Saufi  , Indah Sapta Wardhani  , Philip Habib
Published: February 2025

Septic shock is a life-threatening organ dysfunction accompanied by abnormalities in the circulatory, cellular and metabolic systems, thereby increasing the risk of death due to the body's response to an infection. Sepsis remains a global health and economic problem. The condition of sepsis is caused by increased capillary permeability and decreased peripheral vascular resistance so it is classified as distributive shock. The main treatment for this condition is fluid resuscitation accompanied by administration of inotropic agents (vasopressors), administration of antibiotics and reducing excessive inflammation in the body. Several new studies regarding the efficacy of vasopressin therapy with corticosteroids are also being considered. Therefore, this study will discuss septic shock and its management, especially with a combination of vasopressin and corticosteroids.
Media Permainan Ular Tangga Untuk Meningkatkan Kemampuan Kognitif Berhitung pada Anak Kelas 1 SD Negeri 11 Tanjung Batu
Authors: Hurriyati Dwi , Fatimah Anggun
Published: February 2025

Lembaga pendidikan yang berkomitmen untuk mencetak generasi muda yang berkualitas dan berakhlak. Di Sekolah Dasar Negeri 11 Tanjung Batu, kemampuan berhitung siswa menjadi salah satu fokus utama dalam pembelajaran matematika. Kemampuan berhitung merupakan salah satu keterampilan dasar yang sangat penting bagi anak-anak di usia sekolah dasar. Meskipun telah dilakukan berbagai upaya untuk meningkatkan kemampuan ini, masih terdapat beberapa tantangan yang dihadapi. Metode yang digunakan yaitu Pengabdian masyarakat yaitu Tindakan Kelas hasil kegiatan anak-anak kelas 1 SD Negri 11 Tanjung Batu mengalami peningkatan kognitif berhitung, membilang, serta mengurutkan bilangan yang signifikan. Melalui media permainan ular tangga anak dapat meningkatkan kemampuan memasangkan lambang bilangan dengan konsep bilangan. Dan juga alat permainan ular tangga ini juga sangat menarik dan disukai serta cocok untuk dimaninkan oleh anak seusia mereka.
A Danza de La Luna Considerações sobre o corpo em resistência ecofeminista e contra-colonial
Authors: Rolim Ludmilla Reis
Published: February 2025

Esse artigo pretende pontuar aspectos históricos que corroboraram para o surgimento desta manifestação cultural espiritual de origem Mexicana, La Danza de La Luna que é difundida mundialmente na atualidade. Considerando a vivência da autora que, desde 2015, participa de círculos da Danza de la Luna, pretende-se delinear a partir do princípio da prática como pesquisa os impactos e potências vividos nessa experiência para, por fim, tecer reflexões que apontam processos corporais e performativos dessa manifestação como ferramenta de resistência cultural, ecofeminista e contracolonial.
Devir/Tornar-se Terra sem fincar bandeira Diálogos para descolonizar metodologias formativas e de criação em artes
Authors: Coletty Viviana de Souza
Published: February 2025

Este artigo propõe uma conversa sobre processos que investigam e buscam plantar práticas de ensino e processos criativos descoloniais nas artes cênicas, dentro do quadro universitário. O objetivo é compartilhar descobertas e indagações que temos experenciado. Essa busca se dá a partir de um diálogo entre ; propostas de abordagens descoloniais nos processos pedagógicos das artes da cena, e leituras da criação de um estilo de dança, mais especificamente a dança butô de Tatsumi Hijikata (1928 - 1986). Um estilo de dança que se insurge para o mundo de um mergulho do artista em sua mais profunda ancestralidade.
Não escreveram meu nome: Caminho poético para pensarmos epistemologias do vivido
Authors: Costa Silvânia Cerqueira da
Published: February 2025

O presente artigo expõe o percurso escreVivente do processo de criação da perfor-mance/instalação Não escreveram meu nome, a qual traz para o chão a escrita de nomes de mulheres de diferentes gerações, ocultos pelo racismo. A inquietação surgiu com a pesquisa netnográfica de imagens de amas de leite do período colonial, nas quais não constam os nomes das escravizadas que seguram os sinhozinhos, ato que explicita a sutil máscara de silêncio, uma denúncia do apagamento das identidades femininas negras.
FUNDADA SUSPEITA NA ABORDAGEM DE VEÍCULO USADO PARA O TRANSPORTE DE ENTORPECENTES EM FOZ DO IGUAÇU
Authors: Monzon Daiane Andressa
Published: February 2025

Este estudo analisou a eficácia da aplicação da "fundada suspeita" nas
abordagens de veículos realizadas pela Polícia Militar do Paraná (PMPR), pelo
BPFRON, no combate ao tráfico de entorpecentes, com foco na região da
Tríplice Fronteira em 2024. A metodologia envolveu uma abordagem qualitativa
e quantitativa, utilizando dados das apreensões realizadas durante operações
baseadas nesse princípio. O objetivo foi investigar o conceito jurídico da fundada
suspeita, apresentar dados sobre as apreensões realizadas e avaliar a eficácia
dessa prática nas intervenções policiais. Os resultados indicaram que a
aplicação da fundada suspeita foi eficaz na identificação e apreensão de
substâncias ilícitas, como maconha, crack e cocaína, e no confisco de veículos
usados para o transporte de drogas. A análise revelou que a maconha foi a
substância mais apreendida, com destaque para o uso de veículos para seu
transporte. As abordagens realizadas com base em elementos objetivos e no
tirocínio policial demonstraram resultados positivos no combate ao tráfico.
Enhancing teachers’ design thinking mindsets through reflective practice: Cultivating innovation in an upskilling STEAM training program
Authors: ElSayary Areej
Published: February 2025

Promoting innovation in education through enhanced design thinking (DT) mindsets among teachers is a central goal. This study examines the use of reflective practice within an upskilling STEAM training program to achieve this enhancement. The upskilling training initiative examined in this research encompasses a ten-week instructional session characterized by a hybrid learning methodology under the guidance of an instructor. An explanatory mixed method design is employed, starting with a quantitative method (teachers’ survey) followed by a qualitative method (focus group discussion). The participants were in-service K-12 teachers (n = 55) from charity schools across Northern Emirates in the United Arab Emirates. The main results demonstrate that reflective practice significantly contributed to developing teachers’ DT mindsets, fostering empathy, creative confidence, and the ability to navigate uncertainty. Teachers reported increased confidence in guiding students through open-ended problem-solving tasks and adapting their instructional strategies to address feedback from students and peers. This research highlights reflective practice’s transformative potential in elevating teachers’ DT mindsets. For example, through iterative reflection, teachers were better equipped to design STEAM challenges that connect with real-world problems, allowing students to apply creativity and critical thinking. It demonstrates the link between the upskilling STEAM program and the cultivation of innovative teaching methods, equipping educators to nurture creativity and problem-solving skills in students, thereby enriching education.
The sustainable development goals: Past, present and future
Authors: Rosen Marc A.
Published: February 2025

As we are now past the half way mark of the UN Sustainable Development Goals (SDGs) for 2015-2030, it is a prudent time to take stock and look forward, and I do so here from my perspective as founding Editor in Chief of the European Journal of Sustainable Development Research. The SDGs clearly have fostered a much research and numerous initiatives and implementations related to sustainable development, spanning all sectors of societies and their economies. Progress made towards sustainable development has reinforced that there are multiple approaches to sustainable development, varying from region to region and country to country. Despite these advances and successes, progress to date on the SDGs has been far from adequate if humanity and society are to shift towards sustainable development in a significant and meaningful way in the future. This relatively weak progress has stemmed from various factors, some unpredictable and others somewhat foreseeable. It is becoming increasingly evident that the progress on the SDGs by 2030 will not complete the quest for sustainable development. I consequently believe and contend that there clearly is a need to extend and double down on the SDGs for 2030-2045 and beyond.
Novel mechanism for protein delivery in breast cancer therapy: A public health perspective
Authors: Ogunjobi Taiwo Temitope , Nebolisa Ngozi Maryann , Ajayi Rufus Oluwagbemileke , Euba Morenikeji Ibilola , Musa Adnan , Inusah Abdul-Hanan Saani , Adedayo Femi , Jamgbadi Ojoisimi Franca , Afuape Akinwunmi Rapheal , Edema Adeleye Adegboyega , Echesi Stephen Ajuluchukwu , Obasi Daniel Ebubechi , Abdul Sulaimon Olajuwon , Adeyanju Saheed Adegbola
Published: February 2025

Breast cancer is still a major global public health concern, requiring novel treatment strategies that might enhance results and minimize adverse effects. From the perspective of public health, this review highlights the potential of innovative routes for protein delivery in breast cancer treatment to change therapeutic approaches. We investigate sophisticated protein delivery methods, such as ligand-directed targeting, nanoparticle-based carriers, and bioengineered proteins, and evaluate their efficacy in maximizing medication specificity and reducing toxicity through a methodical review of recent literature. According to our research, the distribution of therapeutic proteins to breast cancer cells is greatly enhanced by these innovative delivery methods, which increases treatment efficacy while lowering systemic exposure and side effects. Specifically, biological barriers have been demonstrated to be achievable by targeted delivery systems, which also target the tumor microenvironment. This allows for the localized release of therapeutic medicines at the tumor site. These developments have significant implications, including the possibility of more individualized and minimally invasive breast cancer therapy choices. These innovative delivery methods can improve patient quality of life and adherence to treatment plans by lessening the adverse effects of conventional chemotherapy, which will improve overall treatment outcomes. Looking forward, it will be crucial to conduct more research and development on protein delivery systems. Future directions ought to concentrate on investigating combination medicines, refining delivery systems for practical usage, and carrying out extensive clinical trials to assess efficacy and safety. This study highlights the role of public health in promoting access to these innovations and enhancing cancer care, underscoring the significance of incorporating novel protein delivery systems into treatment options for breast cancer.
Sociologia Religiosa e Apostolado
Authors: Andrade Raymundo Ozanam de
Published: February 2025

A sociologia religiosa é assunto atual. Artigos de revistas, congressos, associações e até mesmo institutos se ocupam em delimitar seu objeto, estudar suas relações com outras ciências, examinar seus métodos. Entre nós já existe um Centro de Estudos de Sociologia Religiosa no Instituto Superior de Cultura Religiosa “Sedes Sapientiae” em São Paulo, sob a direção do P. Nicolas Boer, que é professor da mesma matéria na Faculdade de Teologia Nossa Senhora da Assunção.
Prioritizing Risk Mitigation Strategies in Air Cargo Freight Operations: A Fuzzy TOPSIS Approach
Authors: Kanmaz Umit , Kütahya Cengiz Kerem
Published: February 2025

This study explores the prioritization of risk mitigation strategies in air cargo operations using a Fuzzy TOPSIS methodology. Air cargo operations face multifaceted risks, including operational inefficiencies, cybersecurity threats, regulatory compliance challenges, and environmental concerns. To address these, a structured decision-making framework was developed, integrating expert evaluations with fuzzy logic to rank mitigation strategies across ten criteria, such as cost-effectiveness, operational efficiency, and scalability. Enhanced Data Security Measures emerged as the top-ranked strategy, reflecting the critical importance of cybersecurity in modern logistics. Other highly prioritized strategies, including Resilience Building for Disruptions and Safety Enhancement Protocols, underscore the need for operational stability and safety in a rapidly evolving industry. The study demonstrates the practical applicability of Fuzzy TOPSIS in handling uncertainty and subjectivity in risk management while providing actionable insights for practitioners. Recommendations are offered for the implementation of prioritized strategies and the integration of emerging technologies, such as real-time analytics and AI-driven decision-making models. The findings contribute to advancing the field of risk management in air cargo operations and highlight areas for future research, including dynamic risk assessment and the integration of complementary MCDM techniques.
Revenge in the Sky: The Impact of Organizational Revenge on Organizational Sustainability in the Aviation Sector
Authors: Öztırak Mesut
Published: February 2025

This study aims to examine the impact of organizational revenge intentions on organizational sustainability. A quantitative research method was employed to achieve this objective. The sample of the study consists of 500 employees working in the civil aviation sector. To reach the sample size, an online survey method was use. After the data collection process, the survey results were analyzed using SPSS and SPSS AMOS software. The analysis revealed a significant negative effect of organizational revenge intentions on organizational sustainability. These findings contribute to the understanding of the potential consequences of revenge behaviors in organizations, particularly in the context of the aviation sector, suggesting that managing organizational emotions may play a critical role in fostering long-term sustainability.
Hyperbole in Jordanian Spoken Arabic: A Lexico-Grammatical Analysis
Authors: Al Rousan Rafat M. , Bani Domi Khalid Qasim , Alqadi Kifah Rakan , AlRousan Malak
Published: February 2025

Hyperbole is a linguistic device used to exaggerate emotions, attitudes, beliefs, and ideas. This paper studies the lexico-grammatical forms of hyperbole in Jordanian-spoken Arabic. Specifically, it studies the forms and meaning of hyperbolic expressions in the everyday use of JSA. The study reports findings from a corpus of 1373 hyperbolic expressions collected from naturally occurring conversations between Jordanian friends and family members. This study uses content analysis methods to analyze its data. It also adopts an integrative approach, adapting lexico-grammatical categories from previous studies. The findings reveal that hyperbole in JSA manifests in various lexico-grammatical forms, which interact together to achieve the aim of hyperbole. In addition, single lexical words (nouns, adjectives, verbs, and adverbs) and multi-words (phrases and clauses), thirteen prominent hyperbolic lexico-grammatical forms were identified in this study. They include idioms, similes, extreme terms, temporal, numerical, metaphorical, scale, negation, comparison, repetition, intensifiers, conditional, and proverbs. The findings reveal that idioms were the most frequently accruing prominent lexico-grammatical category, followed by similes and extreme terms. On the other hand, proverbs were the least frequently occurring form. All of these hyperbolic forms are used in JSA to emphasize feelings, attitudes, opinions, and ideas. The study also shows that context is essential in the interpretation of hyperbole in JSA. Finally, this study suggests some recommendations for future research.
Next-Gen pharmaceutical program management: Integrating AI, predictive analytics, and machine learning for better decision-making
Authors: George Stephen
Published: February 2025

Modern pharmaceutical program management advances through integrating artificial intelligence (AI) systems, predictive analytics, and machine learning algorithms. The advanced tools enable researchers, clinicians, and stakeholders to increase their decision quality, accelerate development periods, and minimize costs while focusing on patient wellness. Through large dataset analyses, AI-based algorithms help researchers find therapeutic goals before establishing trial success predictions and perfect scientific study designs. Predictive analytical models help physicians detect side effects before approval, and they direct regulatory review processes to enhance product safety while maintaining effectiveness. Through machine learning algorithms, the healthcare industry identifies novel patterns in patient data that standard clinical approaches would not normally detect. Pharmaceutical decision-making still faces difficulties because of complicated data structures and high research failures among various patient groups. Program management tools of the next generation aim to eliminate current gaps by delivering real-time information that decreases drug development failures, minimizes processing periods, and maximizes global health outcomes. The research investigates the integration method alongside the advantages and future possibilities of AI-based pharmaceutical program management systems.
Pulsatile drug delivery system: A review
Authors: Shelke Amruta P  , Wagh Priti A  , Nikam Sakshi M  , Bhosale Jaydeep J.
Published: February 2025

Pulsatile Drug Delivery Systems (PDDS) are increasingly recognized for their ability to deliver drugs at specific times, tailored to the pathophysiological needs of a disease. This approach enhances therapeutic efficacy and patient compliance. The core concept of PDDS involves a defined lag-time before a rapid drug release, which can be particularly beneficial for treatments requiring synchronization with the body’s natural circadian rhythms. By aligning peak plasma concentrations with these biological cycles, PDDS can improve both the safety and effectiveness of drugs over a 24-hour period.

There are various techniques for achieving pulsatile drug release, including pH-dependent and time-dependent systems. These systems are generally classified into multiple-pulse and single-pulse categories. A common example of a single-pulse system is the rupturable dosage form, which releases the drug in one rapid dose after the lag-time. PDDS offer several advantages, including reduced dosing frequency, minimized side effects, and the potential for targeted drug delivery to specific sites such as the colon.

Several innovative PDDS technologies, including Pulsincap and Diffucaps, have been developed and launched by pharmaceutical companies, further expanding the applications of pulsatile release and improving patient outcomes.
Efficacy of Katibasti in the management of Katishoola: A case study
Authors: ASHLY JOSEPH PARACKAL  , ROOPA BHAT
Published: February 2025

Katishoola is a very common complaint, which is localized Vatavyadhi where Vata dosha affects Katisandhi.In modern it is nearly correlated with Lumbar spondylosis. Katishoola is a disease which is mainly caused by the vitiation of Vata Dosha. In Ayurveda Katishoola comes under Vatavyadhi. Management for this is Katibasti as mentioned in the Ayurvedic Texts. Katibasti is one of the popular Panchakarma therapy described as Bahi Parimarjana Chikitsa (external procedure) in Ayurveda.Here in this case we are discussing a successfully treated simple katishoola in a 48-year-old female patient with sahacharadi taila katibasti.
Dose-dependent effects of vitamin C on oxidative stress and kidney function in Albino Rats
Authors: John Chimerenka Ifenkwe  , Uzochukwu Alozie Ononuju
Published: February 2025

Vitamin C is an essential nutrient that plays a crucial role in various body functions. While it is generally considered safe, high-dose administration has raised concerns about potential toxicological effects. This study aimed to investigate the toxicological effects of high-dose vitamin C administration in animal models. 80 male albino rats which were divided into four groups: Control, Low-dose (100 mg/kg), Medium-dose (500 mg/kg), and High-dose (1000 mg/kg) vitamin C administration were used for the study. Vitamin C was administered orally once daily for 28 days. Oxidative stress and kidney damage were assessed using standard biochemical assays. 4-Hydroxynonenal (4-HNE) levels were measured to assess oxidative stress while urea and creatinine levels were measured to assess the possible effects on the kidneys. Our results show that high-dose vitamin C administration caused significant increases in oxidative stress and kidney dysfunction in rats. These findings suggest that high-dose vitamin C administration may have adverse effects on health, and its use should be approached with caution.
Linitis Plastica and colonic obstruction: A comprehensive review of clinical challenges and outcomes
Authors: Ali Mohtashami  , Jonathan Hew  , Vishak Senthil  , Justin Evans
Published: February 2025

Background: Linitis Plastica (LP) is a rare and highly aggressive form of gastric cancer characterized by diffuse infiltration of the stomach wall, leading to thickening and fibrosis. Due to its insidious onset and lack of early-specific symptoms, LP is often diagnosed at advanced stages, resulting in poor prognosis and limited therapeutic options. This review aims to provide a comprehensive overview of the clinical features, pathophysiology, diagnosis, and treatment options for LP, with a focus on the challenges posed by its association with colonic obstruction.

Methods: This review synthesizes available literature on LP, including studies on its clinical features, diagnostic approaches, treatment options, and emerging therapies. The review also examines advancements in early detection techniques, such as liquid biopsy and imaging modalities, and the role of multidisciplinary care in managing advanced disease.

Results: Early detection remains a major challenge in LP, as most cases are diagnosed after the disease has progressed to advanced stages. Standard treatments, including chemotherapy and surgery, have limited efficacy in improving survival due to the tumor’s diffuse nature and early metastasis. Emerging therapies, such as targeted treatments, immunotherapy, and biomarkers, offer promising avenues for improving outcomes, but further research is needed to fully understand their role in LP management. Advancements in early detection techniques could help identify LP at earlier, more treatable stages. Multidisciplinary approaches integrating chemotherapy, surgery, and symptomatic relief are essential to improving quality of life for affected patients.

Conclusions: The review concludes that future research should focus on personalized treatment strategies, including molecular profiling and immune-based therapies, to offer better treatment options for this aggressive and often fatal condition.
PERTUMBUHAN DAN HASIL KEDELAI EDAMAME (Glycine max L Merril) PADA PERLAKUAN PUPUK KANDANG KAMBING DAN JENIS MEDIA TANAM DI POLYBAG
Authors: Firnandya Farah Sefiefa , Jumadi Rahmad , Redjeki Endah Sri
Published: February 2025

Kedelai edamame (Glycine max (L.) Merril) satu spesies dengan kacang kedelai namun edamame memiliki ukuran lebih besar, rasa lebih manis, teksturnya lebih lembut dibanding kedelai kuning. Kandungan protein lebih tinggi dan lengkap 36% dibanding kedelai lain. Impor kedelai edamame tahun 2018-2019 mengalami peningkatan. Impor kedelai edamame tahun 2018 sebesar 2.585.809 kg dan tahun 2019 sebesar 2.670.086 kg. Penelitian ini bertujuan meningkatkan kualitas dan kuantitas hasil kedelai edamame sehingga mampu memenuhi kebutuhan dalam negri. Penelitian ini dilaksanakan di lahan percobaan Balai Penyuluhan Pertanian Kebomas yang beralamat di Jl. Dr. Wahidin Sudiro Husodo No. 245, Kembangan, Kec. Kebomas, Kabupaten Gresik, Jawa Timur 61124 pada bulan July - September 2024. Rancangan percobaan digunakan RAK Faktorial. Faktor pertama dosis pupuk kandang kambing (P) yaitu P0 (tanpa pupuk), P5 (5 ton.haˉ¹), dan P10 (10 ton.haˉ¹). Faktor kedua yaitu jenis media tanam (M) yaitu M1 (Tanah Grumusol), M2 (Tanah Grumusol + Sekam Padi), M3 (Tanah Grumusol + Cocopeat). Setiap perlakuan diulang hingga tiga kali sehingga terdapat 27 petak percobaan. Variabel yang diamati meliputi tinggi tanaman (cm), jumlah daun (helai), jumlah cabang (cabang), luas daun (cm2), bobot basah brangkasan (g), bobot kering brangkasan (g), jumlah polong (polong), bobot basah polong (g), bobot kering polong (g), bobot basah akar (g), bobot kering akar (g) dan bobot 100 butir (g). Analisis data digunakan yaitu ANOVA dengan uji F0,05 . Jika terdapat perbedaan nyata perlakuan maka dilanjutkan dengan DMRT0,05, uji korelasi dan uji orthogonal polinomial. Hasil penelitian menunjukkan terdapat interaksi nyata perlakuan dosis pupuk kandang kambing (P) dan jenis media tanam (M) pada variabel tinggi tanaman (cm), jumlah cabang (cabang) dan bobot kering brangkasan (g). Orthogonal polinomial pada komponen hasil menunjukkan penggunaan pupuk kandang kambing pada variabel bobot basah brangkaan 1,9 ton.haˉ¹, bobot kering brangkasan 2,03 ton.haˉ¹, jumlah polong 1,9 ton.haˉ¹, bobot basah akar 1,94 ton.haˉ¹, bobot kering akar 1,25 ton.haˉ¹, dan bobot 100 butir 2,35 ton.haˉ¹.
PENGEMBANGAN KOMIK DIGITAL TENTANG BHINNEKA TUNGGAL IKA DAN PANCASILA UNTUK SISWA SEKOLAH DASAR
Authors: Nurfauzi Bayu , Trieyani Elga Tira , Karmila Shintyasari Hadi , Husna Siti Khadijah Nurul , Aulia Zahra , Nugraha Rana Gustian
Published: February 2025

The number of bullying cases that occur in elementary schools caused by differences in ethnicity, religion, race, and culture that occur in the environment of elementary school students, researchers try to provide education about the values of unity in diversity and Pancasila. This research aims to develop digital comic learning media to increase understanding of Bhinneka Tunggal Ika and Pancasila in elementary school students. The research method used is R&D (research and development) with a development model, namely ADDIE and data collection techniques in the form of media expert validation test questionnaires and student response questionnaires. This product design stage uses Canva from the initial to the final stage. The results of the media validation test received a score of 76% with a category worth using with revision, then the researcher made revisions according to the direction of the validator. After that, researchers conducted product trials to individuals with an average individual trial assessment of 82.33% with very feasible criteria, small group trials of 86.45% with very feasible criteria and large group trials of 87.67% with very feasible criteria. The evaluation results refer to expert validation data and product trials, indicating that this digital comic can be applied to elementary school students in learning and nonlearning.
PENGEMBANGAN VIDEO ANIMASI EGOISME DI SEKOLAH DASAR
Authors: Berliana Giscka Putri , Sritindiani Heti , Luminary Hilwa Tiara , Poja Lulu Laksita Anin , Nugraha Rana Gustian
Published: February 2025

Seiring berkembangannya zaman, karakter egois di siswa sekolah dasar semakin menonjol dan kompleks.Oleh karena itu, penelitian ini bertujuan untuk mengembangkan sebuah video animasi untuk mengatasi perilaku egois dikalangan siswa sekolah dasar. Jenis penelitian yang digunakan adalah R&D (Research and Development) dengan model pengembangannya yaitu ADDIE, dan teknik pengumpulan data berupa angket uji validasi ahli media dan angket respon siswa. Tahap design video menggunakan Canva dan Pinterest, sedangkan tahap pengembangan menggunakan Capcut. .Hasil dari Penelitian ini yaitu: (1)Video Animasi dinyatakan valid berdasarkan ahli media dengan hasil penilaian 80% dengan kriteria” layak”. Setelah diuji validasi, selanjutnya produk diuji cobakan pada tiga kategori yaitu perorangan dengan presentase 91,46% dengan kriteria sangat layak,uji coba kelompok kecil dengan presentase 92,89% dengan kriteria sangat layak, uji coba kelompok besar dengan presentase 89,66% dengan kriteria sangat layak. Dari hasil penelitian tersebut terbukti bahwa pengembangan video animasi yang telah dibuat sangat layak untuk di terapkan dalam pembelajaran maupun non pembelajaran.
PENGARUH MEDIA PEMBELAJARAN, METODE PEMBELAJARAN, DAN DUKUNGAN ORANG TUA TERHADAP MINAT BELAJAR SISWA SMP BUANA WARU SIDOARJO
Authors: Laili Nurul , Darmawan Didit , El Yunusi Muhammad Yusron Maulana
Published: February 2025

Student interest in learning is influenced by various factors. If these components are well integrated, then student interest in learning will increase and produce achievement. Education in the 21st century emphasizes the aspect of using technology in learning, besides that methods and parental support are also needed to support the success of learning. This study aims to assess the effect of media, methods, and parental support on student interest in learning at SMP Buana Waru Sidoarjo. Using quantitative methods in data analysis techniques. The results obtained show that the use of learning media, methods, and parental support has a significant influence on student interest in learning. The teaching and learning process supported by high interest and enthusiasm from students can make learning much more effective. This is also supported by experts' opinions on how effective learning can be done, one of which is the relationship between media, appropriate and fun teaching methods with high student interest.
MODEL KOOPERATIF TIPE TEAM ASSISTED INDIVIDUALIZATION (TAI) TERHADAP HASIL BELAJAR MATEMATIKA SISWA KELAS IV SD NEGERI 2 KERTOSONO
Authors: Nadila Indah Nur , Hamdan Hamdan , Mandasari Novianti
Published: February 2025

Subjek pada penelitian ini yaitu siswa kelas IV SD Negeri 2 Kertosono yang berjumlah 28 siswa. Berdasarkan hasil penelitian diperoleh bahwa nilai rata-rata siswa pada saat Pre-Test (Tes Awal) yaitu 45,92, kemudian setelah mengikuti pembelajaran matematika dengan menggunakan model kooperatif tipe Team Assisted Individualization (TAI), mendapat nilai rata-rata Post-Test (Tes Akhir) yaitu 84,18 dengan presentase 100%. Sedangkan pada perhitungan uji Z diperoleh Zhitung 10,30 > Ztabel 1,64, maka Ha diterima yaitu nilai rata-rata hasil belajar matematika kelas IV SD Negeri 2 Kertosono setelah mengikuti pembelajaran matematika dengan menggunakan model pembelajaran kooperatif tipe Team Assisted Individualization (TAI) secara signifikan tuntas lebih dari atau sama dengan Kriteria Ketercapaian Tujuan Pembelajaran (KKTP) 68 dan Ho ditolak yaitu nilai rata-rata hasil belajar matematika kelas IV SD Negeri 2 Kertosono setelah mengikuti pembelajaran matematika dengan menggunakan model pembelajaran kooperatif tipe Team Assisted Individualization (TAI) secara signifikan belum tuntas kurang dari Kriteria Ketercapaian Tujuan Pembelajaran (KKTP) 68
GAME EDUKASI EDUCAPLAY, DAPATKAH MENINGKATKAN MOTIVASI BELAJAR PESERTA DIDIK?
Authors: Alfinarum Ayu , Untarti Reni , Anwar Syaikhul
Published: February 2025

The problem found was that at SD Negeri 2 Sumbang, the learning implemented was still conventional or teacher-centered learning, this situation made students tend to get bored and there was a lack of teachers in utilizing technology to attract students' attention and motivation to learn. The aim of this research is to increase learning motivation by implementing the educaplay educational game in the Pancasila Education class V class at SDN 2 Sumbang. This research is Classroom Action Research (PTK), data was obtained through observation, documentation and questionnaires. The results of this research show that, by implementing the educaplay educational game in the Pancasila Education subject in class V of SDN 2 Sumbang, students' learning motivation can be increased. Evidenced by the increased percentage of learning motivation, in cycle 1: Strongly Agree 50%, Agree 36%, and Disagree 14%, cycle 2: Strongly Agree 61%, Agree 35%, and Disagree 4%, and cycle 3: Strongly Agree 80%, Agree 18%, and Disagree 2%.  From the increase in achievement for each cycle, it can be concluded that the implementation of the educaplay educational game can increase students' learning motivation in the Pancasila Education subject in class V at SDN 2 Sumbang.
DAMPAK PENGARUH LINGKUNGAN TERHADAP PERKEMBANGAN ANAK USIA DINI
Authors: Ningsih Esti , Cintia Echa
Published: February 2025

The environment is a factor that plays an important role in early childhood development. The environment can influence children's growth and Submitted Jun xx, 201x Accepted Jul xx, 201x Published Aug xx, 201x development in terms of physiological, psychological, and sociocultural aspects. The purpose of the study was to determine the influence of the environment on early childhood development. The research method used a qualitative approach, namely a literature study by collecting data from articles Keywords: related to the topic over the past ten years. Collect and analyze information from books, journals, newspapers and other research articles. Based on the Environment Early Childhood Development Impact of influence results of the study, it is concluded that the environment around children affects early childhood development. There are factors that can affect children's growth and development, namely environmental factors which include family parenting and nutrition, school and community. By paying attention to environmental factors that affect children's growth and development and their impact, we can take the necessary actions to create an environment that supports optimal growth and development for future generations Keywords: Envioronment Early Childhood Development Impact of influence
UPAYA MENINGKATAN KEMAMPUAN PEMECAHAN MASALAH DAN MOTIVASI BELAJAR PESERTA DIDIK PADA KELAS XI MERDEKA 1 MELALUI MODEL PEMBELAJARAN PBL (PROBLEM BASED LEARNING) PADA SMA NEGERI 4 PURWOKERTO
Authors: Azizah Nur
Published: February 2025

This research aims to analyze whether the application of the Problem Based Learning (PBL) learning model can improve the problem solving abilities and learning motivation of students in class XI Merdeka 1 SMA Negeri 4 Purwokerto. This research uses a classroom action research method which consists of two cycles with stages of planning, action, observation and reflection. Data is collected through tests, questionnaires and documentation. The data analysis technique used is descriptive analysis. The research results show that the application of the PBL learning model can improve students' problem solving abilities and learning motivation. This is proven by an increase from cycle 1 to cycle 2 with an average problem solving ability test score from 54.60% to 73.03% and an increase in the percentage of high learning motivation from 8.33% to 33.33%.
Strategi guru, budaya literasi, anak usia dini
Authors: Lihah Muf
Published: February 2025

Budaya literasi anak usia dini yang kuat memberikan pondasi yang kokoh bagi kemampuan membaca, menulis, dan berbicara anak-anak di masa depan. Dengan mendukung lingkungan yang kaya akan literasi dan memberikan pengalaman positif dalam membaca dan menulis sejak usia dini, anak-anak akan lebih siap untuk sukses dalam pendidikan dan kehidupan mereka. Guru dapat membantu membangun fondasi yang kuat untuk budaya literasi pada anak usia dini dengan menerapkan berbagai strategi yang tepat. Penelitian ini bertujuan untuk mendeskripsikan bagaimana guru-guru mengembangkan strategi dalam membangun budaya literasi pada anak-anak usia dini di TK Diponegoro 51 Batuanten. Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan teknik pengumpulan data observasi, wawancara, dan dokumentasi. Analisis data dilakukan dengan cara pengumpulan data, reduksi data, penarikan kesimpulan, dan keabsahan data dengan triangulasi. Hasil penelitian menunjukkan bahwa terdapat beberapa strategi yang digunakan oleh guru dalam membangun budaya literasi pada anak usia dini. Strategi tersebut antara lain mencakup penggunaan metode pembelajaran yang berorientasi pada pengembangan literasi, pemanfaatan berbagai jenis bahan bacaan yang sesuai dengan perkembangan anak, pengintegrasian literasi dalam berbagai aktivitas pembelajaran, serta kolaborasi dengan orang tua untuk menciptakan lingkungan literasi yang mendukung di rumah. Temuan ini menunjukkan pentingnya peran guru dalam membentuk budaya literasi sejak dini dan memberikan kontribusi positif terhadap perkembangan literasi anak-anak. Implikasi dari penelitian ini adalah perlunya dukungan yang terus-menerus dari berbagai pihak, termasuk sekolah, orang tua, dan masyarakat, untuk memperkuat budaya literasi di lingkungan pendidikan anak usia dini.
UPAYA PENINGKATAN HASIL BELAJAR PANCASILA MELALUI PENDEKATAN TEACHING AT THE RIGHT LEVEL PADA SISWA KELAS VI
Authors: Fitriani Fitriani , Rulviana Vivi , Wijiastuti Nurul
Published: February 2025

This study was motivated by the need to improve the learning outcomes of grade VI students at SD Negeri 01 Klegen who were identified as unsatisfactory. It was found that the mismatch between learning materials and students' abilities had the potential to lead to low engagement in the learning process and difficulty in understanding the material, which ultimately had a negative impact on academic achievement. Looking at potential solutions, the Teaching at the Right Level (TaRL) method was considered as an approach that could accommodate various student characteristics, without relying on scores as a reference. With a focus on personalizing teaching by teachers, the TaRL approach is expected to help develop students' potential and improve learning outcomes according to their developmental level. This research, which used descriptive quantitative analysis techniques, was conducted in two cycles. In the pre-cycle stage, only 7 students (24.13%) reached the mastery level. However, after the application of the TaRL approach, there was a significant increase, where the number of students who reached the level of completeness increased to 23 students (84.20%) in cycle one and 26 students (86.48%) in cycle two.
PENERAPAN MEDIA DIOSILIR (DIORAMA SIKLUS AIR) SEBAGAI UPAYA PENINGKATAN HASIL BELAJAR SISWA KELAS IV SEKOLAH DASAR
Authors: Azizah Umi Nur , Maruti Endang Sri , Zahro Fachriyatu
Published: February 2025

This research aims to implement Discovery Learning-based LKPD on material changing the shape of objects to improve the learning outcomes of class IV students at SDN 1 Sepang Jaya. This is because in this research the model used is the Discovery learning model where this model applies inquiry-based instruction learning. The discovery learning model will encourage students to investigate for themselves, build on past experiences and knowledge, use intuition, imagination, creativity, search for new information to find facts, correlations and new truths. The method used in the data collection period carried out in this research was through tests and observations of student behavior during the learning process using the Discovery Learning Model and Conventional Model. The method used is as follows; tests, as data collection instruments, include pretests and posttests; observation, namely making direct observations of the research object; documentation, is a record of events. In order to obtain more objective and valid research results, researchers conducted validity and reliability tests on each test item.
MODEL PEMBELAJARAN THREADED UNTUK MENGEMBANGKAN KEMAMPUAN BERPIKIR KREATIF SISWA SEKOLAH DASAR
Authors: Rosiana Gina , Aprilia Lestari2 Virna , ‘Alimah Nabiilah
Published: February 2025

Pelaksanaan proses pembelajaran di beberapa sekolah dasar masih menekankan pada penguasaan materi pembelajaran atau pembelajaran berbasis teori. Pembelajaran terpadu tipe threaded merupakan salah satu tipe pembelajaran terpadu yang membuat untaian antara beberapa keterampilan yaitu keterampilan berpikir, keterampilan sosial, kecerdasan ganda dan keterampilan mengorganisir. Pendidikan merupakan faktor yang paling penting dalam menentukan kehidupan masa depan suatu bangsa. Dibutuhkan kemampuan berpikir kreatif siswa agar mereka dapat mengembangkan kemampuan berpikir yang lainnya. Berpikir kreatif adalah kemampuan berpikir dengan menggunakan cara-cara yang baru untuk menemukan solusi-solusi yang unik terhadap persoalan. Penelitian ini bertujuan untuk menganalisis keefektifan model pembelajaran tipe threaded dalam mengembangkan keterampilan berpikir kreatif siswa sekolah dasar sebagai salah satu keterampilan penting di abad ke-21. Metode yang digunakan dalam kajian ini adalah analisis wacana terkait hasil penelitian yang berkaitan dengan kemampuan berpikir kreatif siswa di sekolah dasar. Adapun yang dianalisis yaitu tentang kemampuan berpikir kreatif, pengembangan berpikir kreatif, dan bagaimana berpikir kreatif di sekolah dasar. Berdasarkan hasil analisis wacana dari beberapa referensi artikel dan buku penunjang lainnya, dapat disimpulkan bahwa untuk mendukung proses pembelajaran yang meningkatkan kemampuan berpikir kreatif siswa diperlukan suatu pengembangan model pembelajaran tipe threaded yang difokuskan pada kesadaran tentang pengetahuan dan proses berpikir siswa yang dapat mengembangkan kemampuan berpikir kreatifnya dalam menyelesaikan permasalahan-permasalahan.