bluuebunny/crossref_metadata_2025 huggingface dataset:
РОЛЬ ПСИХО-ЕМОЦІЙНОЇ СФЕРИ ВАГІТНОЇ ЖІНКИ У ПЕРЕБІГУ ГЕСТАЦІЙНОГО ПРОЦЕСУ
Authors: Фартушок Тетяна , Фартушок Надія , Мильо Христина
Published: April 2021

В ХХІ столітті в загальній структурі захворюваності людини зростає рівень патології, детермінованої психологічною дезадаптацією до стресогенних умов оточуючого середовища. І це, в свою чергу, передбачає обрання нових пріоритетів первинної профілактики патології людини, зміщення акценту на психотерапевтичні підходи і практики, а в констекті вагітності ₋ на використання психокорекційних технологій у прегравідарній підготовці [2]. Вагітність і пологи ₋ це нормальні події у житті жінки. В той же час, це великий фізіологічний стрес, джерело переважно позитивних емоцій, але воно поєднане з серйозною перебудовою організму жінки та з можливими негативними подіями: гестозом, загрозою переривання вагітності, іншими її ускладненнями [1].В умовах негативного демографічного балансу, патологічний перебіг вагітності та ускладнені пологи, як і раніше, залишаються актуальними в Україні [3]. Функціональний і фазовий характер репродуктивної системи жінки з навколишньою її емоційною атмосферою зумовлює ситуаційний фізіологічний стрес, біологічні, емоційні та функціональні модифікації якого иожуть трансформувати нормальну ситуацію в патологічний стрес, створюючи умови психосоматичного ризику [4,5]. A.A.Ухтомський (1978) вперше виявив ефект корроборації (перемикання), якому він дав назву “домінанта” (від латинського dominans – панувати), котра є головним системоутворювальним фактором антропосоціогенезу [7,8,9]. Основними властивостями домінанти є підвищена збудженість, стійкість збудження, інертність збудження та здатність поєднувати збудження (Батуєв О.С., 2010). Паралельно вченню про домінанту прогресувала розквітом рефлекторна теорія І.П. Павлова. Ці два основні фізіологічні наукові напрямки якнайкраще доповнювали один одного. Мета дослідження ₋ врахування гінекологом особливостей психології вагітних та породіль для коректної оцінки стану жінки та ефективного ведення вагітності. Дослідження психоемоційної сфери вагітної проводять у двох напрямках: 1) вивчення психологічного статусу жінки в період вагітності для з’ясування ролі характеріологічних особливостей і факторів із категорії психоемоційних, що сприяють або обтяжують симптоматику ускладнень вагітності, тобто з позицій сучасних теорій психосоматики; 2) з позицій перинатальної психології. Їх неможливо відокремити один від одного Висновки і пропозиції.Психологія вагітності та материнства набуває особливої альтуальності у сучасній науковій психології через її суб’єктивну важливість серед етапів у житті кожної жінки. Останніми роками у науковій літературі підкреслюється істотна роль психологічних чинників, які супроводжують період вагітності. Адже під час вагітності відбуваються не тільки фізіологічні, а й суттєві психологічні зміни у житті жінки, які залежать від багатьох факторів впливу, в т.ч. і від терміну гестації. Особливого значення набуває і готовність жінки до материнства. Саме материнська сфера протягом вагітності зазнає суттєвих змін, які відбиваються у переживанні жінкою симптоматики вагітності, у її активності та психічному стані.
ІНФОРМАЦІЙНА БЕЗПЕКА, ОХОРОНА І ЗБЕРЕЖЕННЯ КУЛЬТУРНОЇ СПАДЩИНИ: ТЕНДЕНЦІЇ ТА СТРАТЕГІЧНІ НАПРЯМИ
Authors: Горбань Юрій , Куліш Юлія
Published: April 2021

В інформаційному суспільстві збереження набутої інформації як інтелектуальної спадщини нації є вагомим чинником розвитку цього суспільства, становлення і формування інформаційної культури. Інформація цінувалася у всі часи і щоб володіти нею, відбувалися протиборства, вбивства, війни. У наші часи вчасно подана, правдива та в повному обсязі отримана інформація має не меншу цінність. Ця цінність визначається не тільки витратами на її створення, а й величиною отриманого від її можливої реалізації прибутку. Мета роботи – визначити й схарактеризувати заходи зі збереження інформаційного потенціалу; дослідити механізм організації інформаційної безпеки держави та охорони культурної спадщини; висвітлити правовий аспект з досліджуваного питання, що регулюється законодавством України. Доведено необхідність прийняття відповідних правових та організаційних заходів для забезпечення свободи обміну інформацією і високого ступеня інформаційної безпеки.
ІНФОРМАЦІЙНО-АНАЛІТИЧНА ДІЯЛЬНІСТЬ СУЧАСНОЇ УНІВЕРСИТЕТСЬКОЇ БІБЛІОТЕКИ
Authors: Винокурова Світлана
Published: April 2021

В статті висвітлено сучасні завдання інформаційно-аналітичної діяльності бібліотек закладів вищої освіти та певний досвід у їх вирішенні наукових бібліотек окремих університетів України, зокрема Наукової бібліотеки Київського національного університету культури і мистецтв. Охарактеризовано загальні тенденції та деякі перспективи подальшого розвитку ІАД.
Intususcepción en niño con COVID-19
Authors: Garcia Gladis , Zaldaña Juan
Published: April 2021

En lactantes, la invaginación intestinal es la causa más común de obstrucción intestinal, y en niños, hasta el 30% de los casos tiene una enfermedad viral previa. Ocurre con mayor frecuencia entre 4 y 10 meses de edad. Su incidencia oscila entre 0.24 y 2.4 por cada 1000 nacidos vivos, y su tasa de mortalidad es de 2.1 por millón de nacidos vivos en los EE. UU. Presentamos el caso de un lactante con test positivo  para SARS-CoV-2.
Competitive Routing on a variant of Delaunay Triangulation
Authors: Rathore Virendra Singh
Published: April 2021

The concept of
Delaunay triangulation is thought to be currently one of the best
implementations in the sampling arena, whether it be technical or a non
technical domain. Considering the network congestions which cause a competitive
routing in any given area of the network, Delaunay triangulation has come to be
proven as a good, if not the best, remedy to solve the mentioned problem. Dr.
Prosenjit Bose presented a good argument back in November 2011 where he proved
that connecting the nodes of any given network using the concepts of Delaunay
Triangulation gave the best path between nodes, taking the least amount of time
for the communication and reducing the competitive routing in the network by
reducing the spanning ratio and path length by almost 5/sqrt(3). Here in this
study we use the concepts of the Delaunay Triangulation to design a Java
application which analyses given a set of random nodes in a plane, it connects
each of them with the use of Delaunay Triangulation so that the nodes have the
best path to communicate with each other.
Precursors of pancreatic cancer in background of chronic opisthorchiasis
Authors:   Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Rayn V. U. ,   Regional Clinical Hospital, Khanty-Mansiysk, Persidskiy M. A. ,   Regional Clinical Hospital, Khanty-Mansiysk, Malakhova E. V. ,   Regional Clinical Hospital, Khanty-Mansiysk, Anuchina I. V. ,   Regional Clinical Hospital, Khanty-Mansiysk, Khalikova A. A. ,   Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Timofeeva Ya. E. ,   Regional Clinical Hospital, Khanty-Mansiysk, Bereshkeeva L. V. ,   Regional Clinical Hospital, Khanty-Mansiysk
Published: April 2021

Aim. To establish the association between pancreatic cancer precursor lesions and chronic opisthorchiasis. Materials and methods. A single center case-control study was conducted at a low-volume pancreatic surgery center in Khanty-Mansiysk. We retrospectively collected morphological data from 47 pancreatoduodenectomies performed for pancreatic ductal adenocarcinoma. The study group included 23 cases of pancreatic ductal adenocarcinoma with concomitant chronic Opisthorchis felineus invasion which were compared to 24 controls consisting of “pure” cancer. Qualitative analysis was performed using χ2 Pearson criterion. Exact Fisher test was used for small samples. Time to progression and overall survival rates were calculated using Kaplan-Meier survival analysis. Data were collected and analyzed in Statistica 7.0. Results. PanINs were seen in 41,7% pancreata resected for ductal adenocarcinoma of the head and in 95,7% cases of pancreatic cancer in background of chronic opisthorchiasis (р = 0,000; 95% CI 3,5-268). PanIN high grade were observed only in opisthorchiasis group. In mixed pathology invasive cancer component tended to be more dedifferentiated and advanced when compared to pure cancer group (p = 0,029). Median disease free survival was 9 mo. in both groups and overall survival was 13 mo. in non-opisthorchiasis group and 15,3 mo. in opisthorchiasis group (р = 0,437). Conclusion. Chronic opisthorchiasis is associated with pancreatic intraepithelial neoplasia. Pancreatic ductal adenocarcinoma in background of opisthorchiasis with preneoplastic lesions tend to be more advanced in stage and poorly differentiated. Disease free and overall survival have no statistically significant differences in patients with and without Opisthorchis felineus invasion.
Medical and social aspects of the problem life expectancy (literature review)
Authors:   Surgut State University, Surgut, Karpin V. A.
Published: April 2021

The current demographic situation is characterized by a significant increase in the aging of the population. The aging process is accompanied by the inclusion of certain active mechanisms that contribute to the disruption of the life of the human body. The complex of these mechanisms fits into the concept of metabolic syndrome. The presented materials convincingly prove that the problem of metabolic syndrome is largely a gerontological problem. Its development contributes to premature aging of the body and shortening the life span of the population of the planet. The development and widespread implementation of special dispensary Programs, as well as complex targeted therapy of various pathogenic manifestations of this syndrome, will significantly improve public health and increase life expectancy.
On rehabilitation of patients with complex regional pain syndrome in the upper extremity
Authors:   Nizhnevartovsk city children’s polyclinic, Nizhnevartovsk, Burmatov N. A. , Sergeev K. S. ,   Tyumen State Medical University, Tyumen, Gerasimov A. A. ,   Ural State Medical University, Ekaterinburg, Zykova N. V. ,   Surgut Trauma Centre, Surgut
Published: April 2021

The aim of this study is to improve the results of treating patients with Complex Regional Pain Syndrome (CRPS). Materials and Methods. The study analyses the use of intratissual electric stimulation (ITES) combined with the complex of special exercises for recovery of upper extremity function at the outpatient rehabilitation stage in patients (179 persons) who underwent osteosynthesis of upper limb bones, or nerve and tendon transfer surgery. The objective pain syndrome and trophic innervation of the injured extremity assessment was performed by measuring skin surface electric potential using Gerasimov’s method. The results were interpreted according to “Personalized system of assessing the results of treating trauma and orthopedic patients”. Results. “Combination treatment in the rehabilitation of the upper extremity” proved to be effective to fight pain syndrome and trophic dysfunction of the nervous system. It allows the patient to do the complex of special exercises to prevent limb contracture if used during late rehabilitation period. It is an efficient method of preventing and treating neurotrophic dysfunction. The use of this technique leads to early mobilization and the reduction of treatment period and the period of temporary work disability. Conclusion. The pathogenetically substantiated method of treating upper extremity, the use of intratissual electric stimulation (ITES) at the outpatient rehabilitation stage of humerus fractures prove to be effective.
Música, lenguaje y educación una reflexión analítica desde George Steiner
Authors: Martínez José Alejandro
Published: April 2021

Cuando se indaga sobre las relaciones del arte y la educación, es muy poco probable encontrar de manera espontánea uniones o tendencias con el lenguaje como tema preponderante, sin embargo, en este pequeñísimo ejercicio de ilustración reflexiva proponemos recuperar a una de las mentes mas brillantes en el siglo XX y XXI; George Steiner y desde su obra maestra; "después de Babel" recomponer analíticamente, el tema de la traducción como dinámica inevitable a la multiplicidad de lenguas, ejercicio que lo llevó a un no desestimable ejercicio sobre la anatomía del lenguaje, para con esa referencia reconstructiva identificar y resaltar uniones o roces del lenguaje en una de sus manifestaciones mas insospechadas pero eminentemente comunicativa: la música. Asi, entendemos y pretendemos desarrollar las ideas mas contundentes y profusas de Steiner con respecto a la traducción desde la difícil caracterización del lenguaje como fenómeno inevitable de la relación humana, desde y por la comunicación, rescatando así un fenómeno que a partir de la educación tradicional resulta de un desconocimiento apabullante y temible, que englobaría a la sensibilidad artística - musical (o carencia de la misma) un fenómeno que inunda y sumerge a la si no entera juventud, si quizás, a la grande mayoría de estos. Proyectamos así un camino educativo que desde el fenómeno de la traducción en el sentido de Steiner arguye al lenguaje ahondando en las relaciones insospechadas del mismo en una correspondencia tripartita que identifica las posibilidades de la música con respecto a la traducción que es en suma una de los objetivos fundamentales de la educación, la comunicación con los otros, aquí, los mas jóvenes.
Compilación de procesos de investigación en geometría, estadística y sistemas dinámicos
Authors: Díaz Mora Héctor Felipe , Villarraga Palomino Jesús Antonio , López Prieto Leidy Estefanía , Piedrahíta Novoa Luis Hernando
Published: April 2021

El presente libro muestra los resultados más relevantes de algunos procesos de investigación de la Licenciatura en Matemáticas de la Universidad de Cundinamarca, en temas como estadística, geometría y sistemas dinámicos. En el capítulo de estadística descriptiva en R se presenta una introducción clara y concisa a los conceptos estadísticos descriptivos básicos. Un curso de estadística está presente en el plan de estudios de diferentes carreras, siendo a menudo uno de los cursos más útiles por su transversalidad en los diferentes campos. Se plantea además una exposición detallada de cada concepto mostrando ejemplos trabajados con el software R , para el cual se presenta una ilustración clara y paso a paso para que el lector se familiarice con el lenguaje que se utiliza en este software y de este modo pueda trabajar de manera autónoma con las herramientas que brinda este para el análisis estadístico. En la sección de geometría elemental del triángulo se considera inicialmente las propiedades de las homotecias. Luego se hace un estudio de la geometría del triangulo desde el punto de vista euclideo y después se contrasta algunos resultados bajo la metodología de las homotecias. El trabajo realizado en sistemas dinámicos es el resultado de una aplicación de las ciencias exactas en agropecuarias, se realizó un experimento en el que se implementó un lombricultivo tomando como base una población de lombriz roja californiana (Esenia Foetida) bajo condiciones semicontroladas. Con este estudio se logró la optimización del abono producido por estos anélidos tomando como referencia datos existentes en manuales de lombricultura; este sustrato fue puesto a prueba junto al abono químico y un testigo en un cultivo de habichuela, mediante un diseño experimental de bloques completamente al azar con tres tratamientos y tres repeticiones por cada uno, obteniendo el humus los mejores resultados.
Wheat dwarf virus and its impact on the 2020 harvest in some regions of Ukraine
Authors: Mishchenko L. , Dunich A. , Mishchenko I. , Dashchenko A. , Boyko O. , Skufinskyi O. , Kyrychenko A. , Kozub N. , Mukha T.
Published: April 2021

Goal. Identify the virus that causes symptoms of dwarfism and non-earing of winter wheat (reduced or no ear formation), and investigate its effect on plant yields. Methods. Visual diagnostics, enzyme-linked immunosorbent assay in double sandwich modification (DAS-ELISA), polymerase chain reaction, biometric, determination of yield and its structure, statistical data processing. Results. A study of winter wheat varieties from Vinnytsia, Khmelnytsky, Kyiv, Chernihiv and Cherkasy regions with symptoms of dwarfism, yellowing of leaves and non-earing. ELISA and PCR have shown that the disease is caused by Wheat dwarf virus. The absence of Wheat streak mosaic virus, Barley yellow dwarf virus, Brome mosaic virus and Wheat spindle mosaic virus (Wheat streak mosaic virus) was shown in the studied samples. It was found that the dwarf wheat virus significantly reduces the number of grains in the ear (3.3 times), the weight of grains from the ear (3.4 times) and the weight of 1000 grains (1.9—3.3 times) depending on the degree of damage plants (from moderate to severely affected). Conclusions. The circulation of dwarf wheat virus in agrocenoses of five regions of Ukraine and a significant negative impact of the disease on the yield of winter wheat plants have been established. The obtained results indicate the need for constant monitoring and testing of plants for the presence of wheat dwarf virus in Ukraine.
Giant sumpweed (Cyclachaena xanthiifolia (Nutt.) Fresen.): seed stocks, seedling dynamics, methods control
Authors: Kurdiukova O. , Tyshchuk O.
Published: April 2021

Goal. To assess the degree of danger of contamination of the sowing layer and an increase in stocks of Giant sumpweed seeds in the soil, the timing and dynamics of seedlings emergence, to develop a control pathway aimed at their reduction.

Methods. The studies were carried out by route-expeditionary surveys and field experiments. The potential soil contamination was determined washing weed seeds from soil samples. Weeds were counted in 4—6-single repetitions.

Results. In ruderal biotopes, the infestation of 0—20 cm of the soil layer by weed seeds has not changed since 2009 and amounted to 244.6—384.1 thousand pcs./m2. At the same time, the infestation of soils with Giant sumpweed seeds increased 2.0—2.7 times. In crops of cultivated plants, the total weediness of the soil increased by 1.8—3.5 times, and Giant sumpweed — by 4.7—12.1 times and reached 25.0—85.0 and 14.5—15.5 thousand pcs./m2, respectively. Seed germination of Giant sumpweed was observed only in the spring and early summer periods. In the Dry and Southern Steppe, Giant sumpweed emerged in the middle-end of March, in the Northern Steppe — during April, Forest-Steppe — from early May to early June. In crops of cultivated plants the density of young crops of Giant sumpweed did not exceeded 23—62 pcs./ m2, and on uncultivated lands — from 636 to 862 pcs./m2. On uncultivated lands the effective control in crops of Giant sumpweed was carried out by mowing weeds, in crops of cereals — by herbicides of leaf action in the tillering stage, late arable crops by pre- and after emergence harrowing combined with inter-row cultivation.

Conclusions. Potential soil infestation by seeds of Giant sumpweed in ruderal biotopes since 2009 increased by 2.0—2.7 times, and in crops of cultivated plants — by 4.7—12.1 times and reached 25.0—85.0 and 14.5—15.5 pcs./ m2 thousand, respectively. Seed germination of Giant sumpweed occurred only in spring and early summer. The number of seedlings on ruderal areas reached 636—862 plants/m2, and in crops — 23—62 plants/m2. Effective control of Giant sumpweed on uncultivated lands was achieved by mowing weeds, in sowing of grain crops with leaf herbicides in the tillering phase, row crops — by pre-emergence and post-emergence harrowing in combination with inter-row cultivation.
The category of “economic security” in the constitutions of the states of Africa and Oceania (comparative analysis experience)
Authors: Baranov Vladimir , Nazarychev Dmitriy
Published: April 2021

The article makes an attempt at an interdisciplinary analysis of the category of “economic security”, which has found ambiguous expression in the constitutions of foreign states. The experience of a comparative economic and legal study of the definition of the phenomenon under consideration is presented, a logical-epistemological and technical-legal study of the constitutions of the states of Africa and Oceania, which are characterized by a bright economic differentiation, is carried out.
Institutional problems of the implementation of the economic security strategy of Russia
Authors: Chebotarev Stanislav , Anischenko Alexander
Published: April 2021

The article analyzes the specific problem of ensuring the economic security of the Russian Federation, which has received the figurative name in the scientific literature “institutional trap”, the essence of which is associated with the lack of the necessary coordination of macroeconomic regulators. This problem is based on objective prerequisites due to the non-transitivity of social relations in general and relations in the system of public administration and the economy, in particular.
HYPODYNAMIA AS A FACTOR MODIFYING FUNCTIONAL MORPHOLOGY OF HUMAN PLACENTA
Authors: Gubina-Vakulik Galina I. , Belyaev Sergei G. , Doroganova Olena V. , Nestertsova Natalia S. , Fedota Olena M. , Belyaeva Iryna S.
Published: April 2021

The aim: Study of the functional morphology of placenta in a sedentary lifestyle of a woman during pregnancy.
Materials and methods: Object of the study: placentas obtained as a result of deliveries at term from women, urban residents, aged 20–40 years old, leading a sedentary
lifestyle, and patients with a sufficiently high level of physical activity, the criteria of which corresponded to WHO recommendations. Immunohistochemical and morphometric
studies of the placentas were carried out, followed by statistical analysis
Results: Prerequisites for reducing the efficacy of the functioning of fetoplacental complex with a sedentary lifestyle were sclerosis, the formation of intervillous fibrinoid
and fibrinoid substitution of terminal villi. The inclusion of compensatory mechanisms in the form of placental hypertrophy, angiomatosis, sinusoidal transformation of the
capillaries of terminal villi, thinning of the syncytiocapillary membrane associated with an increase in the content of von Willebrand factor in the villus syncytiotrophoblast, in
aggregate, normalizes the exchange between maternal and fetal blood and creates certain prerequisites for the successful completion of pregnancy. However, thinning of the
syncytiocapillary membrane increases the risk of rupture and direct contact of the internal media of the mother and the fetus.
Conclusions: Sedentary lifestyle of a pregnant woman leads to structural and functional changes in the placenta, which can be a serious prerequisite for the development of
pathological abnormalities in the function of the “mother-placenta-fetus” system. To a certain extent, these changes are leveled due to compensatory processes in the placenta,
the margin of efficacy of which needs further investigation.
VAGINAL CUFF INFECTION AFTER HYSTERECTOMY IN UKRAINE
Authors: Salmanov Aidyn G. , Vitiuk Alla D. , Hrynchuk Solomiia Ya. , Bober Anna S. , Hrynchuk Oksana B. , Berestooy Oleg A. , Chernega Tetiana V. , Rud Victor O.
Published: April 2021

The aim: To obtain the first estimates of the current prevalence of vaginal cuff infection after hysterectomy and antimicrobial resistance of causing pathogens in Ukraine.
Materials and methods: We performed a retrospective multicenter cohort study was based on surveillance data. The study population consisted of women who had an
abdominal, vaginal or laparoscopic hysterectomy from 2017 to 2019 in 7 women hospitals of Ukraine. Definitions of vaginal cuff infections were used from the Centers for Disease
Control and Prevention’s National Healthcare Safety Network, USA.
Results: Total 12.6% women’s after hysterectomy had vaginal cuff infections. Of these cases, 20.3% after abdominal, 15.5% vaginal and 4.1% laparoscopic hysterectomy were
identified. The predominant pathogens of VCUF infections were: Escherichia coli (18.6%), Enterobacter spp. (12.4%), Staphylococcus aureus (10.8%), Streptococcus spp. (9,7%),
Klebsiella pneumoniae (8.2%), Pseudomonas aeruginosa (7.6%), Enterococcus faecalis (7,0%) and Proteus spp. (7.0%).
Methicillin-resistance was observed in 12.9% of S. aureus (MRSA) and 9.7% CoNS. Carbapenem resistance was identified in 7.3% of P.aeruginosa isolates. Resistance to thirdgeneration
cephalosporins was observed in 8.9% K. pneumoniae and E.coli 11.9% isolates. The overall proportion of extended spectrum beta-lactamases (ESBL) production
among Enterobacteriaceae was 22.7%. The prevalence of ESBL production among E. coli isolates was significantly higher than in K. pneumoniae (32.6%, vs 12.3%).
Conclusions: Vaginal cuff infections in women after hysterectomy are common in Ukraine and most of these infections caused by antibiotic-resistant bacteria. The incidence
of VCUF infections after hysterectomy differs depending on the type of surgical procedure.
CD68+ M1 MACROPHAGES IS ASSOCIATED WITH PLACENTAL INSUFFICIENCY UNDER FETAL GROWTH RESTRICTION
Authors: Berezhna Varvara A. , Mamontova Tetiana V. , Gromova Antonina M.
Published: April 2021

The aim: To elucidate the possible involvement of M1 and M2 macrophages in the placentas of women, whose pregnancies were complicated by fetal growth restriction (FGR)
and resulted in term births after 37 weeks of gestation and preterm births up to 37 weeks of gestation.
Materials and methods: CD68+ and CD163+ macrophages were studied by immunohistochemical method, placental morphology in the placentas of 16 women whose
pregnancies were complicated by FGR and resulted in term births at a gestational age after 37 weeks (1-st group, n = 7) or resulted in preterm births at a gestational age up to
37 weeks (2-nd group, n = 9). The control group consisted of 10 placentas of women with physiological pregnancies and births.
Results: Women 2-nd group showed significantly low weight of the placenta, a short gestation period at the time of delivery, and a prolonged labor period than women of the
control group (p <0.001; p <0.001; p <0.05, respectively). The level of CD68+ and CD163+ macrophages in the placentas of women 2-nd group was significantly higher than
in woman 1-st group (p <0.001, p <0.001, respectively). A significant correlation was found between the expression level of CD68+ monocytes in the intervillous space and the
weight of a newborn (r = – 0.765; p = 0.016) in women 2-nd group.
Conclusions: These studies suggest that in the placentas of women whose pregnancies were complicated by FGR and resulted in preterm births, the increased activation of CD68+
macrophages of the pro-inflammatory pool may be associated with disorders of the vascular and stromal component of the villous chorion with the development of involutive
and dystrophic changes. In general, this fact probably determines the progress of chronic placental insufficiency and aggravates the development of fetal growth restriction.
MORPHOLOGICAL CHANGES OF THE GASTRIC MUCOSA WHILE USING ANTIAGGREGANTS AND PANTOPRAZOLE (AN EXPERIMENTAL STUDY)
Authors: Yankovetska Alla G. , Vernyhorodskyi Serhii V. , Paliy Iryna G. , Zaika Serhii V.
Published: April 2021

The aim: Was to characterize the morphological peculiarities of the gastric mucosa at early stage of prescription of acetylsalicylic acid (ASA) and clopidogrel as well as to study
the impact of pantoprazole on the gastric mucosa to optimize the prophylaxis and treatment of gastropathies induced by ASA and clopidogrel.
Materials and methods: The experiments were performed on 77 non-linear white male rats with the average weight of 150-180 g. Depending on the aim of research, the
animals were divided into 7 groups.
Results: The administration of pantoprazole in combination with ASA and clopidogrel presented positive trends in neutral glycoproteins amount and contributes to preventing
GM necrotic lesions by amplification of protective properties of mucus and stabilization of apoptotic activity of gastric epithelial cells.
Conclusions: 1. According to our study findings, administration of ASA in combination with clopidogrel results in 2,5 times higher risk of GM erosive lesions.
2. One of the most significant morphological manifestations of gastropathy in ASA and clopidogrel regimen is the development of microerosions, which are poorly diagnosed
by macroscopic examination.
3. The use of PAS-reaction makes possible to identify damage to the basal membrane of superficial epitheliocytes, which may be a top-priority morphological criterion of
gastropathy induced by ASA or clopidogrel in the absence of an inflammatory reaction.
4. Administration of pantoprazole in combination with ASA and clopidogrel contributes to preventing GM necrotic lesions by amplification of protective properties of mucus and
stabilization of apoptotic activity of gastric epithelial cells.
BIOFILM FORMING ACTIVITY OF NON-FERMENTING GRAM-NEGATIVE BACTERIA
Authors: Kovalchuk Valentyn P. , Nazarchuk Oleksandr A. , Burkot Vita M. , Fomina Nadiia S. , Prokopchuk Zoіa M. , Dobrovanov Oleksandr
Published: April 2021

The aim: To study the influence of chemical, physical factors on the biofilm forming activity of P. aeruginosa, A. baumannii.
Materials and methods: Biofilm forming activity of P. aeruginosa (10 isolates) and A. baumannii (10 isolates) was studied in nutrient media of different composition. There
was used the method in 96-well crystalline violet staining plates with spectrophotometry (STAT FAX®4300, wavelength of 620 nm).
Results: Results showed that in standard medium (trypto-soy broth), strains of P. aeruginosa (90%) and A. baumannii (60%) obtained high biofilm forming activity.
A. baumannii formed biofilms even in sterile water. Biofilm forming activity of urease positive P. aeruginosa increased in the medium with 1.0% urea. Both Acinetbacteria and
Pseudomonas intensively produced their biofilms in the presence of 5% serum or sub-bacteriostatic concentrations of levofloxacin in the media. High concentrations of sodium
chloride inhibited their biofilm activity.
Conclusions: Isolates of Acinetobacter and Pseudomonas obtain the protective biofilm-forming ability under such adverse environmental conditions as insufficient nutrients, high
osmotic pressure, the presence of antibiotics but at high concentrations sodium chloride biofilm-formation is stimulated only in the first bacteria and suppressed in the second one.
CLINICAL FEATURES OF TOXIC JAW BONE OSTEOMYELITIS IN DRUG ADDICTS
Authors: Fitkalo Oleh S. , Ohonovskyi Roman Z. , Pohranychna Khrystyna R. , Nahirnyi Yaroslav P. , Netlyukh Andriy V.
Published: April 2021

The aim: The aim of our research is to study the features of toxic osteomyelitis in drug addicts, their diagnosis and comprehensive treatment, aimed at strengthening motivation
for the suspension of the use of psychoactive substances and the elimination of the pathological process in the lower jaw .
Materials and methods: The features of toxic osteomyelitis, complicated by abuse, have been studied on 46 patients in the department of oral and maxillofacial surgery of
Lviv regional clinical hospital during 2013-2019. Psychoactive substances, used by the patients, varied from homemade drugs “Screw” taken by 32 men (69.5%), synthetic drug
amphetamine consumed by 10 men (21,7%) to Subutex used by 4 patients (8,7%) for their pleasure. All the patients underwent comprehensive examination, which included
clinical, laboratory, radiological, pathohistological studies. Almost all patients – 41 ( 89.1% ) underwent sequestrectomy.
Results: Clinical picture progressed quite rapidly in the form of diffuse destructive-necrotic osteomyelitis of the mandible, which was characterized by a severe, atypical course
of the pathological process with permanent inclusion of other additional areas of the lesion of the mandible. The X-ray at this stage showed an increase in destructive processes
in the bone.
Conclusions: Appropriate surgical tactics and pathogenetic therapy are of great importance for toxic osteomyelitis in drug addicts. Due to the treatment, despite the total
destruction of the mandible, it was possible to stop the destructive bone processes and to preserve life for such patients.
BIOLOGICAL METHOD FOR BABESIOSIS DETECTION: THE UNIFIED VERSION IN VIVO
Authors: Torianyk Inna I.
Published: April 2021

The aim is to establish a unified version of the biological method for babesiosis detection in vivo.
Materials and methods: samples (n=257) of biological material of different origin were examined. These included: blood samples from patients (n=6) and cattle (n=15); salivary
gland homogenates (n=28) from 147 imagoes of ticks of the family Ixodidae, 32 imagoes of Ixodes ricinus and 115 imagoes of Dermacentor reticulates; spleen homogenates
(n=63) from mouse-like rodents (Muridae) of the genera Myodes, Microtus, Apodemus and Sylvaemus. In order to cultivate in vivo Babesiae of the species B. microti, Syrian
hamsters were infected with spleen homogenates from mouse-like rodents; for cultivating the B. divergens species Mongolian gerbils and nonlinear white mices were infected
with blood samples from patients and cattle and salivary gland homogenates from ixodic ticks. The technology of modeling was based on the group specificity (differences in
susceptibility to parasites and in parameters of morbidity) of the animals, involved in the experiment (Syrian hamsters, Mongolian gerbils, nonlinear white mices).
Results: Experimental animals were contaminated by means of intraperitoneal inoculation of 0.3 ml samples of biological material (infected with Babesiae). The animals were
infected next day following a day of their preinoculation preparation. The marker parameters for the functional state of experimental animals were as follows: preterm death;
appearance and development of clinical-laboratory signs of disease (hypo- or adynamia, loss of appetite, inertness/absence of reactogenicity to tactile/acoustical stimulation,
postural changes, wetting of fur, pronounced lameness, flatulence, loss of ≥ 25% of body mass) in them; parasitaemia, histodestruction, cellular detritis. Parasitaemia was
detected every two days (beginning with day 8 from the moment of inoculation) by reserves of light and luminescent microscopy. In case of the positive result (revealing of
haemoparasites with Babesia spp.-like morphological and tinctorial signs) the verification of Babesiae with their more precise specific identification was performed using the
technique of polymerase chain reaction (PCR). Preliminary detection of morbidity parameters in each experimental animal with the artificially created immunocompromised
state became an obligatory moment of the described experiment.
Conclusions: The biological method for detecting Babesia spp. in vivo was improved by the author. This result was achieved by using a double reservoir (Syrian hamsters,
Mongolian gerbils and nonlinear white mices with an increased level of susceptibility to parasites) followed by the immunocompromise formation. The use of the improved
version of biological method increased the total rate of revealing of Babesiae, therewith creating an objective basis for optimizing the available ways of detection and study
of Babesiae in vivo.
PROGNOSTIC SIGNIFICANCE OF BLOOD MARKER OF HYPERTROPHY– CARDIOTROPHIN-1 WHEN CARRYING DIFFERENT VARIANTS OF ITS GENE IN MEN WITH ESSENTIAL HYPERTENSION
Authors: Matokhniuk Maryna O. , Limanskiy Oleksandr V. , Maiko Olena V. , Zhebel Vadym , Shevchuk Oleksandra K. , Palii Irina K.
Published: April 2021

The aim: To improve diagnosis of essential hypertension with left ventricular hypertrophy and chronic heart failure in men citizens of Podillya region in Ukraine by determining
the plasma levels of cardiotrophin-1 in patients with different CT-1 gene variants.
Materials and methods: A total of 70 men with no signs of cardiovascular disease and 100 patients with essential hypertension were examined. Among those, 50 participants
had hypertension and left ventricular hypertrophy. Other 50 patients had hypertension complicated by chronic heart failure.
Results: It was established that in patients with essential hypertension the frequency of the pool of genotypes GA + AA is higher than the genotype GG (p <0.05). Plasma CT-1
levels ≥ 122,895 pg / ml can be used for early diagnosis left ventricular hypertrophy, and the cut-off level is ≥ 303.81 pg / ml (sensitivity 85.7%, specificity 92%) for screening
diagnosis of essential hypertension complications in the form of chronic heart failure.
Conclusions: In patients with essential hypertension of varying severity, the GA+АА genotypes of CT-1 gene was found to be dominant. They had higher levels of plasma
concentration CT-1. The threshold levels of CT-1 for screening diagnosis of essential hypertension with hypertrophy and chronic heart failure in males (who were residents of
the Podillya region of Ukraine) were evaluated.
COMPLEX THERAPY OF ATOPIC CHEILITIS
Authors: Ilenko Nataliya M. , Nikolishyna Ella V. , Lytovchenko Iryna Yu. , Atash Bar Fardin
Published: April 2021

The aim: Was to evaluate clinical data after the use of pimecrolimus (1% cream “Elidel”) in patients with mild and moderate severity of atopic cheilitis, according to modern
therapeutic requirements. There was an algorithm of treatment the patients with cheilitis proposed it based on the data from literary sources and personal clinical experience.
Materials and methods: 22 patients with atopic cheilitis aged from 19 to 40 agreed on a clinical examination in accordance with the protocol of the study. Patients were
prescribed “Elidel” in the form of 1% cream for lubrication of the affected areas of the skin and lips, and antihistamine “Erius”, for the normalization of the general condition
used sedatives and vitamins after consultation of specialists in the general profile.
Results: Patients of both groups during the re-examination after 3, 7, 10 days recorded a positive dynamics of the red border of the lips and skin: a significant reduction in the
inflammatory process, normalization of indicators of general blood analysis, improvement in the overall quality of life of patients.
Conclusions: The results of treatment allow to consider 1% cream “Elidel” (pimecrolimus) as a preparation of choice in the complex treatment of patients with atopic cheilitis
of mild and moderate severity.
THE ROLE OF INVASIVE AND NON-INVASIVE MEASUREMENTS OF HVPG IN DECISION MAKING IN PATIENTS WITH PORTAL HYPERTENSION AND ESOPHAGEAL VARICES
Authors: Kern Adam , Arłukowicz Tomasz , Bojko Krystian , Gromadziński Leszek , Bil Jacek
Published: April 2021

Many researchers and clinicians have taken the value of hepatic venous pressure gradient (HVPG) as an essential prognostic factor in subjects with chronic liver disorders. And
HVPG alterations characterize a predictive value in subjects at the beginning of the disease (HVPG 6 – 10 mmHg) as well as in subjects in whom hemodynamically significant
portal hypertension has developed (HVPG ≥ 10 mmHg).
Our review aims to present the feasibility and applicability of HVPG in modern clinical practice in patients with liver cirrhosis, including invasive and non-invasive methods.
HVPG measurement is a feasible method with a favorable safety profile. However, hemodynamically significant portal hypertension also might be determined using non-invasive
options as elastography, magnetic resonance imaging, and indices derived from laboratory parameters, e.g., aspartate aminotransferase-to-platelet ratio, platelet count/spleen
diameter ratio, or VITRO score. Hepatic vein catheterization with the evaluation of HVPG is the current gold standard for determining portal pressure; however, new non-invasive techniques are nowadays more frequently used.
OCCLUSAL TRAUMA OF IMPLANT-SUPPORTED METAL-CERAMIC CROWN: A CASE REPORT
Authors: Fastovets Olena O. , Kotelevskyi Roman A. , Huriev Yurii S. , Kobyliak Serhii S.
Published: April 2021

In this article there is a clinical case of occlusion trauma of implant-supported metal-ceramic crown for prosthetics of central incisor. Its uniqueness is the possibility to save dental
implant after acute occlusion impact, which was strong enough to break ceramic facing of fixed denture, but not able to destroy bone and implant components. The occlusion
force located at the incisal edge of the crown induced a reverse torque to the implant and did not result in its failure or bone resorption. In a year after repeated fixed prosthetics,
the results of clinical examination proved absence of any problem with osseointegration. Literature analysis lets us to suggest, that the phenomenon was caused by protective
action of cortical bone around of dental implant. Besides, in the case of natural tooth, the bone is suddenly compressed against the conical root; it transfers occlusal breaking to the supporting periodontal ligament. A dental implant has no periodontal ligament but can have a rough surface that may preclude implant failure.
MODERN MORPHOLOGICAL DIAGNOSTICS OF ULCERATIVE COLITIS AND IRRITABLE BOWEL SYNDROME: HISTOLOGICAL, HISTOCHEMICAL AND IMMUNOHISTOCHEMICAL CRITERIA
Authors: Snisarevskyi Pavlo P.
Published: April 2021

The aim is to establish diagnostic and differential-diagnostic criteria for UC and IBS based on a complex morphological (histological, histochemical, immunohistochemical) study. Materials and methods: In this study, it was used autopsy and biopsy material – fragments of the mucous membrane of the large intestine. The material was divided into 5 groups. The first group (G 1) included autopsy material from 6 cases, in which, during autopsies and microscopic examination, we found no general pathological processes in the gastrointestinal tract. The second group (G 2) included biopsy material from 34 patients with diagnosed UC of the 1st activity degree. The third group (G 3) included the biopsy material of 27 patients with UC of the 2nd degree of activity. The fourth group (G 4) included biopsy material from 19 patients, diagnosed with UC of the 3rd degrees of activity. The fifth group (G 5) included biopsy material from 82 patients with clinically diagnosed IBS. Histological, histochemical, immunohistochemical, statistical research methods were used. Results: There are characteristic morphological changes in the mucous membrane of the large intestine in UC of varying degrees of activity, such as changes in the architectonics of crypts of varying severity; presence of erosive and ulcerative defects. Inflammatory and desquamative-dystrophic changes take place in the epithelial layer adjacent to erosive and ulcerative defects. The number of goblet cells of crypts decreases and the size of vacuoles in goblet cells reduces. The intensity of mucin secretion contained in the vacuoles of the goblet cells lowers; there is a partial or complete loss of pericryptal myofibroblasts; the proliferative potential of the intestinal crypts epithelium activates. Conclusions: Differential diagnostic criteria, revealed by the author, improve the morphological diagnosis of UC and IBS, optimizing the tactics of managing patients with this colorectal pathology.
REPARATIVE REGENERATION AT THE END OF BONE FILING AFTER OSTOPLASTIC AMPUTATION
Authors: Shevchuk Viktor I. , Bezsmertnyi Yurii O. , Bezsmertna Halyna V. , Dovgalyuk Tetyana V. , Jiang Yankai
Published: April 2021

The aim: To study the role and place of bone grafting in the formation of bone stump after amputation.
Materials and methods: 3 series of experiments were carried out on 44 rabbits with amputation of the thigh in the middle third and stump grafting using osteoplastic hermetic closure of the canal with a thin cortical plate (series I), closure of the canal with a spongy bone (series II), and loose closure of the canal with a cortical graft located at the entrance to the canal at an angle of 30° (ІІІ series). Observation period: 1, 3, 6 months. Histological examination method with vascular filling with 10% mascara-gelatin mixture.
Results: In series I, in the majority of observations, a stump of a cylindrical shape with a bone locking plate of an osteon-beam structure and normalization of intraosseous
microcirculation was formed. A slight displacement of the graft caused a violation of microcirculation. In series II, organotypic stumps were formed in all observations. In series III, incomplete closure of the bone marrow cavity led to sharp microcirculatory disorders and the course of the reparative process with pathological bone remodeling.
Conclusions: The parameters of the favorable course of the reparative process and the formation of the organotypic bone stump are the safety of its cylindrical shape, the
presence of a compact bone structure, normalization of intraosseous microcirculation.
RELATIONSHIP BETWEEN PRE- AND POST-THROMBOSIS FACTORS IN PATIENTS WITH STAGE VD CKD TREATED BY LONG-TERM HEMODIALYSIS
Authors: Storozhuk Oleksiy B. , Shevchuk Sergiy V. , Storozhuk Larysa O. , Dovgalyuk Tetyana V. , Storozhuk Borys G.
Published: April 2021

The aim: To determine informative value of pre-thrombosis, post-thrombosis and anticoagulation factors as well as their correlations for assessment of hemostasis status in patients with stage VD CKD.
Materials and methods: Potential predictors of thrombophilia development as well as their relationships depending on the level of molecular markers of hemostasis were
studied in 88 patients with stage VD CKD undergoing long-term hemodialysis with the view to determine their informative value.
Results: Accumulation of soluble fibrin (sF) was demonstrated to cause moderate reaction of D-dimer (D-d) being insufficient in the absence of reaction of anticoagulant
component of hemostasis. Soluble fibrin levels were found to be associated with D-d concentration (r = 0.39) and functionally inactive prothrombin forms (FIPF) to some extent (r = -0.24). Accumulation of FIPF in individuals with high level of sF implies significant activation of blood coagulation system at the stage prior to thrombin formation. Absence of close relationship between pre- and post-thrombosis indices may be indicative of still preserved potential of anticoagulant component of hemostasis.
Conclusions: Accumulation of FIPF is an early marker of activation of blood coagulation and possible thrombosis. Levels of sF correlate with pre-thrombosis (fibrinogen, FIPF)
and post-thrombosis (D-d) factors being associated with inhibition of anticoagulation processes. Comprehensive study of basic components of hemostasis in patients with VD stage of chronic kidney disease offer broader opportunities in arranging prophylactic measures to prevent thrombophilia.
PROBLEM OF GENITAL PROLAPSES AND THEIR CORRECTION BY NONSURGICAL METHODS
Authors: Chayka Kirill V. , Lavrenuik Yulia V.
Published: April 2021

The aim: to determine the most optimal method of genital prolapse correction among the available nonsurgical methods from the perspective of differentiated approach. Materials and methods: using the methods of comparison, analysis and synthesis, we have compiled and processed the world’s data from such major search databases as PubMed, EMBASE, Cochrane over the last ten years. Conclusions: the detection of genital prolapses at an early stage and the early nonsurgical treatment can prevent the disease progression, eliminate the symptoms, especially urinary problems in most patients, and improve the life quality.