bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression patterns of CD147 impact the prognosis of liver hepatocellular carcinoma
Authors: Xu Ji-yun , He Hong-Jie , Wu Peng , Li Wen-bin
Published: March 2023

Objectives
1) To explore the pattern of CD147 expression and its applicability in the prognosis of liver hepatocellular carcinoma (LIHC).
2) To establish hazard ratio and probability points for predicting the prognosis of HCC by correlating CD147 expression with clinical characteristics.
3) To determine if CD147 can be a reliable biomarker in LIHC prognosis.
Methods
CD147 expression profile in LIHC and corresponding clinical data were obtained from The Cancer Genome Atlas (TCGA) database. The expression patterns of CD147 were then validated by analyzing data from the Gene Expression Omnibus (GEO) database. In addition, CD147 Immunohistochemistry (IHC) in LIHC was obtained from the Human Protein Atlas (HPA). CD147 expression patterns and clinical characteristics in the prognosis of HCC were analyzed by accessing the UALCAN web resource. Accuracy, sensitivity, and specificity of the CD147 expression profile in predictive prognosis were determined by the Time-dependent Receiver Operating Characteristic (ROC) curves. Kaplan-Meier curves were plotted to estimate the hazard ratio (HR) of survival in LIHC. Univariate and multivariate Cox regression proportional hazards analyses of CD147 expression levels and clinical characteristics as prognostic factors of LIHC were performed. Nomograms were used to establish probability points and predict prognosis.
Results
Data from TCGA and GEO databases revealed that CD147 was significantly overexpressed in LIHC (p = 1.624e-12 and p = 1.2e-05), respectively. The expression of CD147 and prognosis of LIHC were significantly correlated with the clinical characteristicsof LIHC as per the data from the UALCAN web resource (p < 0.05). Kaplan-Meier analysis of CD147 expression in LIHC revealed that the high expression groups showed poor prognosis and an HR of survival > 1 [(Log-rank test, p = 0.000542, HR (in high expression groups) = 1.856, 95% CI (1.308, 2.636)]. ROC curves were plotted to analyze the 1-year, 3-year, and 5-year survival rates, the Area under the ROC curve (AUC) values were 0.675, 95% CI (0.611–0.74); 0.623, 95% CI (0.555–0.692); and 0.664, 95% CI (0.582–9.745) respectively. Univariate Cox analysis of CD147 expression and clinical characteristics of LIHC, and multivariate Cox analysis of CD147 patterns and pTNM-stage showed significant differences [(Uni-Cox, p = 0.00013, HR = 1.42437, 95% CI (1.8838, 1.70723) and p = 0.00066, HR = 1.37612, 95% CI (1.14521, 1.65359); Multi-Cox, p = 0.00578, HR = 1.50746, 95% CI (1.12637, 2.0175) and p= 0.00336, HR = 1.44319, 95% CI (1.12941, 1.84415)]. Nomograms were plotted to establish the probability points and predict prognosis, the total points ranged from 0 to 180, and the C-index value was 0.673, 95% CI (0.6–1.0), p < 0.01.
Conclusions
Overexpression of CD147 was correlated with poor prognosis in LHIC. CD147 expression profile combined with clinical characteristics can reliably predict the prognosis of HCC. CD147 can serve as a biomarker to predict the prognosis of HCC.
The expression and prognostic significance of CCNB1 in colorectal cancer based on TCGA database
Authors: Chen Guo , Wang Feiqing , Tian Tingting , Yang Bin , Yang Zhu , Tang Dongxin
Published: March 2023

Background
Numerous studies have shown that cell cycle-associated protein B1 (Cyclin B1, CCNB1) is overexpressed in many cancers and is involved in cancer cell growth, differentiation, apoptosis, and metastasis. However, the biological functions and molecular mechanisms of CCNB1 in colorectal cancer (CRC) still remain unclear.
Methods
Herein, the HPA database and the UCSC genomic database were used to analyze the mRNA and protein expression levels of CCNB1 in different tissues of humans or vertebrates. The TIMER database was used to evaluate the expression of CCNB1 in various cancer tissue samples and adjacent normal tissue. R statistical software (version 4.2.1) was employed to analyze the relationship between CCNB1 expression and clinicopathological characteristics in the TCGA database. Kaplan-Meier survival curve and Cox regression were performed to evaluate the prognostic value. Receiver operating characteristic (ROC) curve analysis was applied to assess the diagnostic value of CCNB1. Functional enrichment analysis of CCNB1 and its co-expressed genes was performed to explore the potential molecular mechanisms of CCNB1 in CRC. The correlation of critical cell-cycle regulators and the protein-protein interaction (PPI) network of CCNB1 and CRC was established through the STRING (Search Tool for the Retrieval of Interacting Genes) website and GEPIA database.
Results
Significant upregulation of CCNB1 was observed in a variety of tumor tissues, with limited tissue specificity and tumor specificity. TCGA database and immunohistochemistry data demonstrated that CCNB1 expression was significantly upregulated in CRC tumor tissues. In addition, CCNB1 expression was correlated with the clinical stage and TNM stage. The progression-free survival (PFS) was considerably improved in the CCNB1 high-expression group. Univariate and multifactorial Cox analysis indicated that CCNB1 could not be used as an independent prognostic factor for patients with CRC. Moreover, we found that genes such as BCAS3, ZBTB4, PTTG1, H2AZ1, LRP1B, KCNJ9, and SCARNA7 could be potential targets for regulating CCNB1. The gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) analyses revealed that CCNB1 was implicated in multiple cancer-related signaling pathways and biological processes. Meanwhile, CCNB1 expression was significantly correlated with the immune infiltrating levels of diverse immune markers. CCNB1 expression was positively correlated with tumor mutation burden and negatively correlated with several immune checkpoint genes. In addition, the efficacy of chemotherapeutic medicines such as 5-Fluorouracil, bexarotene, bleomycin, camptothecin, and cisplatin significantly differed between the high and low CCNB1 expression groups.
Conclusion
CCNB1 could be a promising biomarker for predicting the diagnosis and prognosis of CRC patients and a potential novel molecular target for tumor immunotherapy.
Synthesis and characterization a new polyoxomolybdate C34H114Fe2Mo12N18Na2O66 and study of its catalytic activity in the production of 1,2,3-triazoles
Authors: Yousofvand Asmaa , Amini Mojtaba , Hosseinifardc Mojtaba , janczak Jan
Published: March 2023

A new polyoxomolybdate with a formula of [(C6H12N4-CH3)2Na2(H2O)8](C6H12N4-CH3)2[(H0.5)N(CH2O)3FeMoO18.5(OH)2.5]2·10H2O(1)was synthesized. The structure of the synthesized polyoxomolybdate was investigated by single crystal X-ray diffraction analysis and several other identification techniques such as FT-IR and EDX analysis. It was confirmed that each unit cell of1contains one cation [(C6H12N4-CH3)2Na2(H2O)8]4+and two hexamethylenetetramine cations (C6H12N4-CH3)+, two polyanions [(H0.5)N(CH2O)3FeMoO18.5(OH)2.5]3-with ten water molecules in the crystal lattice. In polyanion, molybdenum metals are bonded to two terminal oxygen atoms and two μ2- (Mo-Mo) and μ3- (Mo-Fe-Mo) bridging oxygen atoms. Iron in the center of the polyanion1is also surrounded by three deprotonated oxygens of trimethanolamine ligand and three μ3- (Mo-Fe-Mo) bridging oxygen atoms. This new polyoxomolybdate was used as an efficient catalyst in the azide-alkyne cycloaddition reaction to produce various 1,2,3-triazoles with high yields.
Two Parallel PageRank Algorithms via Improving Forward Push
Authors: Zhang Qi , Tang Rongxia , Yao Zhengan , Liang Jun
Published: March 2023

PageRank, originally designed to rank web pages, has been widely applied in various fields. With the increasing scale of graphs, accelerating PageRank computation has become an urgent need, and designing parallel algorithms is a feasible solution. In this paper, we propose two parallel PageRank algorithms, IFP1 and IFP2, which are improvements upon the state-of-the-art Personalized PageRank algorithm, Forward Push. Theoretical analysis indicates that IFP1 can take advantage of the DAG structure of a graph, where dangling vertices can improve convergence rates and unreferenced vertices can decrease computation amount. IFP2 further improves upon IFP1 by pushing mass to dangling vertices only once but rather many times, decreasing computation amount even further. Experiments on six datasets illustrate that both IFP1 and IFP2 outperform the Power method, with IFP2 reaching up to 49 times faster than Power method with 38 parallelism.
Surgical ablation for atrial fibrillation: impact of diabetes mellitus
Authors: Kogan Alexander , Grupper Avishay , Sabbag Avi , Ram Eilon , Jamal Tamer , Nof Eyal , Fisman Enrique (Zvi) , Levin Shany , Beinart Roy , Frogel Jonathan , Raanani Ehud , Sternik Leonid
Published: March 2023

Background: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Surgical ablation or "maze procedure" is an option for patients with (AF) undergoing concomitant or isolated cardiac surgery. The aim of this study was to evaluate the impact of DM on early and long-term outcomes of patients following surgical AF ablation.
Methods: We performed an observational cohort study in Israel’s largest tertiary care center. All data of patients who underwent surgical AF ablation, between 2006 and 2021 were extracted from our departmental database. Patients were divided into Group I (non-diabetic patients) and Group II (diabetic patients). We compared the two groups with respect to freedom from recurrent atrial arrhythmia, and mortality rate.
Results: The study population included 606 patients. Group I (non-DM patients), consisting of 484 patients, and Group II (DM type 2 patients), comprised 122 patients. Patients with DM were older, had more hypertension and incidence of cerebrovascular accident (CVA)/transient ischemic attack (TIA), higher EuroSCORE (p <.05 for all), and a longer bypass time - 130±40 vs. 122±36 min (p=0.028). The mean follow-up duration was 39.0 ± 22.7 months. Freedom from atrial fibrillation was similar between the non-DM and DM groups after a 1-year follow-up, 414 (88.2%) vs. 101 (87.1%) (p = 0.511), after a 3-year follow-up, 360 (86.3%) vs. 84 (79.9%) (p = 0.290) and after a 5-year follow-up, 226 (74.1%) vs. 55 (71.5%) (p = 0.622) respectively. Furthermore, 1- and 3-year mortality was similar between non-DM and DM groups, 2.5% vs. 4.9%, (p = 0.226) and 5.6% vs. 10.5% (p = 0.076) respectively. 5-year mortality was higher in Group II (DM patients) compared with Group I (non-DM patients), 11.1% vs. 23.4% (p = 0.009).
Conclusion: Surgical ablation had a high success rate, with freedom from recurrent atrial arrhythmia at 1- 3- and 5- years follow-up in both the DM and non-DM groups. Furthermore,1- and 3-year mortality after surgical ablation was also similar in both groups. However, 5-year mortality was higher in the DM group.
Metal Matrix Composite Fabricated from Electrospun PAN, EGNS/PAN Nanofibers and AL 5049 Alloy by Using Friction Stir Processing
Authors: sobhy saleh , Elbadawi Rehab E. , Zoalfakar Said H.
Published: March 2023

This work is an attempt to fabricate aluminum (AA 5049) matrix composites (AMCs) reinforced with electrospun polyacrylonitrile (PAN) nanofibers and consisting of exfoliated graphite nanosheets (EGNS/PAN) by utilizing friction stir processing (FSP) to improve the mechanical characteristics of AA 5049. PAN and EGNS/PAN nanofibers were fabricated using the electrospinning technique. The average diameter of the electrospun PAN nanofibers is 195 ± 57 nm, and after EGNS incorporation is 180 ± 68nm. The incorporation of nanofiber reinforcement can enhance the mechanical characteristics of AA5049. The mechanical characteristics of AA5049 can be enhanced by the procedure of incorporating nanofibers, making them an ideal choice for applications in the automotive and aerospace industries. PAN and EGNS/PAN nanofiber reinforcement enhanced the hardness to 89 and 98 Hv, respectively. Also, the ultimate tensile strength was raised to 291 MPa and 344 MPa, respectively.
WITHDRAWN: Impact of E-nam on Organic Agriculture Farmers' Economic Growth: a Smart-pls Approach
Authors: SARAT SARAT KUMAR SAMANTARAY , FARHAN MOHD , PRITPAL PRITPAL SINGH , Amit Amit Kakkar
Published: March 2023

To achieve the aim of doubling organic agriculture farmers' income, new sources of revenue and improved possibilities must be identified. The online digital market attempts to reduce transaction costs, bridge information gaps, and facilitate market access for organic agriculture farmers and other stakeholders. To improve efficiency in the current system, the government of India (GOI) developed a National Agriculture Market in 2016 by merging all of the country's existing APMCs marketplaces through a shared electronic platform known as e-NAM. The e-NAM is a mandatory delivery-based trading platform that may aid in lowering the cost of intermediation and increasing organic agriculture farmers' price realization by boosting marketing efficiency and introducing transparency to agriculture marketing. The current study was undertaken in six E-NAM mandis located in four districts of Odisha to evaluate the efficiency of e-NAM, particularly on farmer involvement and the online pricing value system as a result of e-NAM. Data was obtained from organic agriculture farmers, merchants, and mandi authorities during a field survey, as well as live trading on e-NAM commodities prices. The current study has a broader marketing coverage since it identifies farmer concerns and their perspectives in the overall marketing of various goods and also exposes facts about organic agriculture farmers having difficulties in marketing their output through e-NAM.
The genomic domestication landscape is orchestrated by transcription factors regulating brain and craniofacial development
Authors: Benítez-Burraco Antonio , Uriagereka Juan , Nataf Serge
Published: March 2023

Domestication transforms once wild animals into tamed animals that can be then exploited by humans. The process entails modifications in the body, cognition, and behavior that are essentially driven by differences in gene expression patterns. Although genetic and epigenetic mechanisms were shown to underlie such differences, less is known about the role exerted by trans-regulatory molecules, notably transcription factors (TFs) in domestication. In this paper, we conducted extensive in silico analyses aimed to clarify the TF landscape of mammal domestication. We first searched the literature, so as to establish a large list of genes selected with domestication in mammals. From this list, we selected genes experimentally demonstrated to exhibit TF functions. We also considered TFs TFs displaying a statistically significant number of targets among the entire list of (domestication) selected genes. This workflow allowed us to identify 5 candidate TFs (SOX2, KLF4, MITF, NR3C1, NR3C2) that were further assessed in terms of biochemical and functional properties. We found that such TFs-of-interest related to mammal domestication are all significantly involved in the development of the brain and the cranio-facial skull, as well as the immune response and lipid metabolism. A ranking strategy, essentially based on a survey of protein-protein interactions datasets, allowed us to identify SOX2 as the main candidate TF involved in domestication-associated evolutionary changes. These findings should help to clarify the molecular mechanics of domestication and are of interest for future studies aimed to understand the behavioral and cognitive changes associated to domestication.
Validation of a shortened MR imaging protocol for pediatric spinal pathology
Authors: Wu Winnie Shu Yu , Miller Elka , Hurteau-Miller Julie , Thipse Madhura , Kapoor Cassandra , Webster Richard , McAuley David , Tu Albert
Published: March 2023

Objective
Conventional pediatric spine MRI protocols have multiple sequences resulting in long acquisition times. Sedation is consequently required. This study evaluates the diagnostic capability of a limited MRI spine protocol for selected common pediatric indications.
Methods
Spine MRIs at CHEO between 2017 and 2020 were reviewed across pediatric patients younger than four years old. Two blinded neuroradiologists reviewed limited scan sequences and results were independently compared to previously reported findings from the complete imaging series. T2 sagittal sequences from the craniocervical junction to sacrum and T1 axial sequence of the lumbar spine constitute the short protocol, with the outcomes of interest being cerebellar ectopia, syrinx, level of conus, filum < 2mm, fatty filum, and spinal dysraphism.
Results
105 studies were evaluated in 54 male and 51 female patients (mean age 19.2 months). The average combined scan time of the limited sequences was 15 minutes compared to 35 minutes for conventional protocols (delta = 20 minutes). The average percent agreement between full and limited sequences was > 95% in all but identifying a filum < 2mm, where the percent agreement was 87%. Using limited MR sequences had high sensitivity (> 0.91) and specificity (> 0.99) for the detection of cerebellar ectopia, syrinx, fatty filum, and spinal dysraphism.
Conclusion
This study demonstrates that selected spinal imaging sequences allow for consistent and accurate diagnosis of specific clinical conditions. A limited spine imaging protocol has potential as a screening test to reduce the need for full sequence MRI scans. Further work is needed to determine utility of selected imaging for other clinical indications.
Crystallographic Orientation-Dependent Resistive Switching in Ga2O3 Thin Films
Authors: Sun Kai , Lei Ming , Yuan Lei , Peng Bo , Yu Miao , Xie Xin-ming , Zhang Yu-ming , Jia Ren-xu
Published: March 2023

Resistive random-access memories (RRAMs) based on wide-bandgap oxides is not only a promising candidate for next-generation non-volatile storage technology but also a suitable family of materials capable of neural network computing. However, the exact mechanism of resistive switching (RS) is not yet clearly understood. In this paper, we investigate Ga2O3-based RRAMs to understand the microscopic-level RS behavior and its relation to the actual process. We find that the oxygenation process during magnetron sputtering affects the crystallization orientation of Ga2O3 thin films. The XRD analysis reveals that the crystalline orientation of Ga2O3 films deposited with O2 flow is [006], and the prepared devices exhibit a lower operating voltage, a higher high/low resistance state ratio, and a more concentrated distribution. By using first-principles calculations and the climbing image nudged elastic band (CI-NEB) method, we show that the oxygen vacancies of the [006] crystalline Ga2O3 films only need to migrate in the (110) plane to form conductive filaments with an energy barrier of 0.65 eV. In contrast, [122] crystalline Ga2O3 films require additional movement in the Z-axis direction, resulting in a much higher energy barrier. Our results can be utilized to modulate the operating voltage and improve the endurance of Ga2O3-based RRAMs.
Results after intraoperative open and endovascular revascularization of acute mesenteric ischemia
Authors: Kapalla Marvin , Choubey Rahul , Weitz Jürgen , Reeps Christian , Wolk Steffen
Published: March 2023

Background: Acute mesenteric ischemia (AMI) is a dreaded condition with a difficult diagnosis and high mortality. Due to different baseline situations, the frequently performed comparison between endovascular and open surgical treatment is interfered by selection bias. The purpose of this study was to review outcomes in AMI treatment with an open or endovascular approach in association with laparotomy to analyze risk factors of mortality for proper risk stratification.
Methods: The clinical data of 74 patients treated for AMI from 2007 to 2021 were retrospectively reviewed and compared. In-hospital mortality was appointed as the primary study endpoint. Risk factors for mortality were identified by using univariate and multivariate analysis.
Results: In total, 61 patients (82%) were treated open surgically (OT) and, 13 patients (18%) with an endovascular approach (ET) in combination with laparatomy. The etiology of AMI was 53% thrombotic and 47% embolic occlusion. The total in-hospital mortality manifested at 43% (n=32) (OT 41% vs. ET 53.8%; P=0.54). As independent risk factors for in-hospital mortality pneumatosis intestinalis (P=0.01), increased lactate concentration (P=0.04) and ischemic intestinal sections (P=0.01) were identified. Additionally, on univariate analysis patient age, congestive heart failure (> NYHA II) and atrial fibrillation were related with higher mortality.
Conclusions: Morbidity and mortality of AMI remainsat a high level. Conventional open or intraoperative endovascular therapy achieved similar results in patients with indication for laparotomy. Advanced disease stage with ischemic intestinal sections at presentation and cardiovascular comorbidities were associated with adverse outcome.
FLORA: Fuzzy Logic - Objective Risk Analysis for Intrusion Detectionand Prevention
Authors: Bamhdi Alwi
Published: March 2023

The rapid take-up of cloud computing and theevolution of the Internet of Things (IoT) has had an alarming impact on society globally in recent years, which hasled to inescapable and relentless cyber-attacks against dataand information systems, posing a devastating safety, protection and security impact with serious consequences in allsectors depending on Information Communication Technology (ICT). It is only a matter of time before the security ofdata, information systems, and cloud computing platformsand their supporting networks, become increasingly significant as high-value assets, as the number of security breachesescalates to new heights. Invasive and continuous cyber-attacks on information systems and critical infrastructurescontinuously cause damaging impacts across multiple sectors. Traditional protection mechanisms like firewalls andencryption systems have proved vulnerable and to a large extent ineffective to counter sophisticated cyber-attacks. Datasecurity and information systems require a highly protectiveand safer security system such as an Intrusion Detection andPrevention System (IDPS) to minimize risk to its absoluteminimum. A well-formulated and designed security systemwith the correct set of policies and strategies for an IDPS hasalso been deemed an extremely useful mechanism in monitoring and recording digital forensic evidence, which can beused in legal prosecution proceedings in different jurisdictions. Such an IDPS can also provide a high detection rate indetecting various classes of cyber-attack attempts. However,in many cases, it is apparent that the performance of IDPSis hampered by an increasing volume of false alarm rates ifit is not properly designed. This indicates a serious concernin ICT security systems since every false alarm can result ina severe impact on the system and its performance. This research proposes the implementation of a unique Fuzzy Logic-Objective Risk Analysis (FLORA) novel technique that canae-mail: ambamhdi@uqu.edu.sareduce false alarm rates during intrusion detection activitiesto a minimum, yet maintain total security at a high level against serious attacks. The highest percentage of error in fuzzymodel prediction is rated at 0.32%. The low level of errorsshows that fuzzy logic predicting countermeasure results isvery close to the actual experimental countermeasure values.The FLORA model accuracy with a rate of 90.11% demonstrates the vulnerability of a system with a very high levelof confidence, and on average it detects DDoS attacks with90.58% accuracy compared to other forms of DDoS attackdetection systems.
A randomized clinical study evaluating thirty-month clinical performance of Class II indirect restorations in endodontically-treated teeth using ceramic, hybrid, and composite CAD/CAM blocks
Authors: Arslan Soley , Karagön Mehmet , Balkaya Hacer , Köse Burak
Published: March 2023

Objectives
This clinical study evaluates the 30-month clinical performance of class II indirect restorations using ceramic, hybrid, composite blocks to endodontically-treated teeth.
Materials and methods
A total of 60 indirect class II restorations were performed in 51 patients using Cerasmart (GC Dental Products Europe, Leuven, Belgium) composite, IPS e.max CAD (Ivoclar Vivadent, Schaan, Liechtenstein) ceramic, and Vita Enamic (Vita Zahnfabrik, Bad Sackingen, Germany) hybrid blocks. All the restored teeth had root canal treatment. The restorations were evaluated using modified FDI criteria for 30 months. The data were analyzed using Kruskal-Wallis analysis and Friedman two-way analysis of variance.
Results
A total of 53 restorations of the 60 restorations could be followed up at the end of 30 months. No statistically significant difference was observed between the groups after 30 months in terms of all criteria evaluated (p > 0.05).
Conclusion
Composite, ceramic, and hybrid blocks showed successful clinical performance in posterior teeth with large material loss.
Clinical relevance:
In the literature, the information about which indirect material is the most appropriate for the restoration of endodontically treated teeth is insufficient. In this study, the restorations made using different indirect materials showed similar clinical performance at the end of the 30-month.
Absence of electric field outside a static charged black hole - something awry in Reissner–Nordström metric
Authors: Singal Ashok k.
Published: March 2023

Using the principle of equivalence, it has recently been shown that the electrostatic field lines of a charge, stationary in the gravitational field, bend exactly like the trajectories of photons emitted isotropically from a source at the charge location and that the fraction of electric flux crossing a surface `below' or `above' the charge is exactly similar to the fraction of photon trajectories intersecting these surfaces, with more flux in the downward direction than upward. Since photon trajectories as well as electric field lines, at any location in the gravitational field, are affected by the local space-time curvature an inference can be drawn that this parallel between the photon trajectories and the electric field lines is a general result. We could then apply these results in the external gravitational field of a black hole, where the trajectories of photons in the gravitational field are already well-known and the behavior of electric field lines of a stationary charge could be inferred therefrom. Accordingly, we show that like photons from a source inside the Schwarzschild radius cannot escape outside, the electric field lines of a charge within the black hole too remain trapped inside the event horizon and, contrary to the conventional wisdom, the electric charge contained inside a static black hole cannot be detected or inferred by an external observer. The absence of electric flux external to a static charged black hole implies that such a charged black hole is not described correctly by the Reissner–Nordström metric.
Regularity for a class of local fractional new maximal operators
Authors: LI Rui , TAO Shuangping
Published: March 2023

This paper is devoted to studying the regularity properties for the new maximal operator Mϕ and the fractional new maximal operator Mϕ,β in the local case. Some new pointwise gradient estimates of Mϕ,Ω and Mϕ,β,Ω are given. Moreover, the boundedness of Mϕ,Ω and Mϕ,β,Ω on Sobolev space is established. As applications, we also obtained the bounds of the above operators on Sobolev space with zero boundary values
MR(2010) Subject Classification 42B25, 46E35
Existence and Ulam Stability of Initial Value Problem for Impulsive Fractional q-Difference Equations
Authors: Allouch Nadia , Hamani Samira
Published: March 2023

This paper, we investigat the existence and uniqueness of solutions for a initial value problem for impulsive fractional q-difference equations involving the Caputo fractional q-difference derivative. The results are obtained using the Banach contraction principle and Krasnoselskii’s fixed point theorems. Also, we discuss the Ulam-Hyers and Ulam-Hyers-Rassias stabilities of its solutions. Finally, an example is given to illustrate the effectiveness of our results.
AMS (MOS) Subject Classifications : 26A33, 39A13, 47H10.
LRS Bianchi Type I String Cosmological Models with Functional Relation on Hubble Parameter
Authors: Singh Abhay
Published: March 2023

LRS Bianchi Type I cosmological models for cloud string is explored. We have considered a cosmological script selecting a functional form for Hubble parameter H which produces cosmological model begin decelerating expansion and inter into accelerating phase at late time. Cosmological outcomes of these models have been studied.
PACS Number: 98.80.Cq, 04.20.-q
Reliability and validity of the Turkish version of the teachers’ basic ICT competence beliefs scale
Authors: KORUKLUOĞLU Pınar , ALCI Bülent , RUBACH Charlott
Published: March 2023

The present study seeks to adapt the Teachers’ Basic Information Communication Technology (ICT) Competence Beliefs Scale, developed by Rubach and Lazarides (2021), into Turkish and test the adapted scale's validity and reliability. The initial step involved conducting a linguistic equivalence of the scale from English to Turkish with 62 English language teachers in a pre-test. Subsequently, the Turkish version of the scale was administered to 356 teachers (69.7% female, 30.3% male) in Turkey to assess its validity and reliability. Participating teachers were from different subjects (e.g., 9.8% science, 7.9% mathematics, 3.7% social science) and school types (27.5% primary school, 55.3% secondary school, 17.1% others). Results of confirmatory factor analysis indicated the original six-factor structure with three first-order and three second-order factors that best fitted the data. The same competence dimensions were indicated in the Turkish contexts as in the original instrument, i.e., information and data literacy; communication and collaboration; digital content creation; safety and security; problem-solving; analyzing and reflecting. The correlations between all six first-order factors were between .58 ≥ r ≥.79. All factors showed good reliability indices, i.e., α > .83, ω > .83 and CR > .72. The adapted instrument was found to be invariant across gender. Mean-level differences among gender groups point to one difference with male teachers reporting higher competence beliefs for digital content creation compared to female teachers. In conclusion, the results of this replication study support the cross-cultural transferability of the original Teachers' Basic ICT Competence Beliefs instrument developed by Rubach and Lazarides (2019).
Experimental Investigation on Behaviour of Folded Plate
Authors: Dhanabal P , Reddy P Narendra , Sushmitha K S
Published: March 2023

Persistence of research was towards the behaviour of folded plate. In this project, we used GGBS blended ferrocement concrete to cover a folded plate 600 mm x 1800 mm x 150 mm. Ferro cement is a building material that is emerging as an alternative for traditional RCC. According to prior research, folded plates are the most cost-effective and visually acceptable option for longer span roofs. First, we built the folded plate model in ANSYS and investigated its behaviour in terms of load versus deflection. Later, for experimental purposes, we cast a folded plate coated with GGBS mixed ferrocement concrete. The results of the experimental inquiry demonstrate that there was an improvement in flexural behaviour when compared to the traditional model. The same was verified using ANSYS findings. ANSYS analysis aids in comparing and summarising experimental data. Both the analytical and experimental inquiry results show that ferro cement structures are a good alternative to RCC since they are less costly and lighter. Because folded plates retain their effectiveness for a longer length of time when Ferro cement is utilised. Ferro cement has made the components smaller to support the load because ferro cement parts are high in stress when reinforcement is spread.
El activismo en las migrantes trabajadoras del hogar: estudio cualitativo en el sur de España
Authors: Aceros Juan C. , Duque Tatiana , Paloma Virginia
Published: March 2023

El trabajo del hogar es un nicho ocupacional opresivo para las mujeres migrantes. Las estrategias que emplean para resistir esta situación han sido poco estudiadas. Este trabajo se interesa por su activismo. Mediante un estudio cualitativo en el sur de España se explora el sentido de dicha acción sociopolítica para las mujeres migrantes. En la primavera de 2020 se entrevistó a once activistas de la Asociación de Trabajadoras y Trabajadores del Hogar de Sevilla. El material se sometió a análisis de contenido. Los significados asociados a su activismo fueron agrupados en cuatro categorías: (1) el horizonte de lucha, (2) las formas de lucha, (3) los niveles de implicación y (4) los retos. Los resultados se limitan a un caso históricamente reciente, y a una muestra pequeña elegida propositivamente; sin embargo, aportan a la comprensión de la agencia de las migrantes, y abre campos de reflexión para las organizaciones de trabajadoras del hogar.
Three ways of representing Art and Geology in Charles III reign: Vesuvius, Gualgayoc mine and Posillipo’s grotto
Authors: Borderías Tejada Rita
Published: March 2023

During the reign of Charles III, the search for information about the different places in his kingdom was constant. The compilation of images culminated, on many occasions, in the commission of artistic objects that were not only limited to the decoration of rooms, but also had the function of transmitting information to their observers. This occurred within the spirit of the Enlightenment, so this information was, in many cases, not easily available the  observers. Sometimes the artists in charge of their representation would not have first-hand access to these natural phenomena or landscapes, so they would have to make use of images made by others in order to carry out their commissions. This is the case of the paintings Vista de la erupción del Vesubio by A. Carnicero, Quadro de Historia Civil y Geográfica del Reyno del Perú by J.I. Lequanda and L. Thiebaut and La gruta de Posillipo en Nápoles by the Real Laboratorio de Piedras Duras del Buen Retiro. The three works analyzed in this work, and belonging to Madrid collections, show the interest that geological nature aroused in various artists of the time.
Geological concepts in the architectural works of Fernando Menis in Tenerife
Authors: Robador Boixereu Rosa , Robador Moreno Alejandro
Published: March 2023

This work relates the various phenomena that act in the earth’s crust and the geological materials with ways of projecting architecture. To carry out this reflection, the work has been divided into two essays. The first one, theoretical, exposes the relations which exist between geology and architecture. It describes, on one hand, the importance of knowing the mechanical behavior of materials; on the other hand, it refers to the relationship of architecture with its environment and in particular the benefits that can be gained from it; in a final section, the types of geological processes which have had influence in the architecture are presented. The second essay of the paper applies the theories previously announced with the description of some selected projects. Due to its close relationship with the matter and energy of the Earth, the work by architect Fernando Menis has been chosen to perform the analysis. The  description is divided into four different projects: Hatching, El Guincho pool, Santísimo Redentor church and Insular Athletics Centre in Tenerife, chosen as representative of each geological phenomenon considered. Finally, one last case study, the MAGMA Congress building is analyzed as a comprehensive  example where all the above phenomena are exposed.
New Insights into the Long Non-coding RNAs Dependent Modulation
of Heart Failure and Cardiac Hypertrophy: From Molecular
Function to Diagnosis and Treatment
Authors: Rezaee Malihe , Masihipour Niloufar , Milasi Yaser Eshaghi , Dehmordi Rohollah Mousavi , Reiner Željko , Asadi Sepideh , Mohammadi Fatemeh , Khalilzadeh Parisa , Rostami Mehdi , Asemi Zatollah , Mafi Alireza
Published: March 2023

Heart failure (HF) is a public health issue that imposes high costs on healthcare
systems. Despite the significant advances in therapies and prevention of HF, it remains
a leading cause of morbidity and mortality worldwide. The current clinical diagnostic
or prognostic biomarkers, as well as therapeutic strategies, have some limitations.
Genetic and epigenetic factors have been identified to be central to the pathogenesis of
HF. Therefore, they might provide promising novel diagnostic and therapeutic approaches
for HF. Long non-coding RNAs (lncRNAs) belong to a group of RNAs that are produced
by RNA polymerase II. These molecules play an important role in the functioning
of different cell biological processes, such as transcription and regulation of gene expression.
LncRNAs can affect different signaling pathways by targeting biological molecules
or a variety of different cellular mechanisms. The alteration in their expression has been
reported in different types of cardiovascular diseases, including HF, supporting the theory
that they are important in the development and progression of heart diseases. Therefore,
these molecules can be introduced as diagnostic, prognostic, and therapeutic biomarkers
in HF. In this review, we summarize different lncRNAs as diagnostic, prognostic,
and therapeutic biomarkers in HF. Moreover, we highlight various molecular mechanisms
dysregulated by different lncRNAs in HF.
Application of Machine Learning in Rheumatoid Arthritis Diseases Research:
Review and Future Directions
Authors: Patil Kose Aparna Hiren , Mangaonkar Kiran
Published: March 2023

Rheumatoid arthritis (RA) is a chronic, destructive condition that affects and destroys
the joints of the hand, fingers, and legs. Patients may forfeit the ability to conduct a normal lifestyle
if neglected. The requirement for implementing data science to improve medical care and disease
monitoring is emerging rapidly as a consequence of advancements in computational technologies.
Machine learning (ML) is one of these approaches that has emerged to resolve complicated
issues across various scientific disciplines. Based on enormous amounts of data, ML enables the
formulation of standards and drafting of the assessment process for complex diseases. ML can be
expected to be very beneficial in assessing the underlying interdependencies in the disease progression
and development of RA. This could perhaps improve our comprehension of the disease, promote
health stratification, optimize treatment interventions, and speculate prognosis and outcomes.
Interactions of Betel Quid Constituents with Drug Disposition Pathways: An
Overview
Authors: Myers Alan L. , Canlas Jasmine
Published: March 2023

Global estimates indicate that over 600 million individuals worldwide consume the areca (betel) nut in
some form. Nonetheless, its consumption is associated with a myriad of oral and systemic ailments, such as precancerous
oral lesions, oropharyngeal cancers, liver toxicity and hepatic carcinoma, cardiovascular distress, and
addiction. Users commonly chew slivers of areca nut in a complex consumable preparation called betel quid (BQ).
Consequently, the user is exposed to a wide array of chemicals with diverse pharmacokinetic behavior in the body.
However, a comprehensive understanding of the metabolic pathways significant to BQ chemicals is lacking. Henceforth,
we performed a literature search to identify prominent BQ constituents and examine each chemical's interplay
with drug disposition proteins. In total, we uncovered over 20 major chemicals (e.g., arecoline, nicotine, menthol,
quercetin, tannic acid) present in the BQ mixture that were substrates, inhibitors, and/or inducers of various phase I
(e.g., CYP, FMO, hydrolases) and phase II (e.g., GST, UGT, SULT) drug metabolizing enzymes, along with several
transporters (e.g., P-gp, BCRP, MRP). Altogether, over 80 potential interactivities were found. Utilizing this new
information, we generated theoretical predictions of drug interactions precipitated by BQ consumption. Data suggests
that BQ consumers are at risk for drug interactions (and possible adverse effects) when co-ingesting other substances
(multiple therapeutic classes) with overlapping elimination mechanisms. Until now, prediction about interactions is
not widely known among BQ consumers and their clinicians. Further research is necessary based on our speculations
to elucidate the biological ramifications of specific BQ-induced interactions and to take measures that improve the
health of BQ consumers.
Curcumin Alleviates Oxidative Stress, Neuroinflammation, and Promotes
Behavioral Recovery After Traumatic Brain Injury
Authors: Zhou Qiang , Gu Jianwen , Chen Bing , Shi Quan-xing , Nie Chuang , Zhao Zhi-ping , Wang Tao
Published: March 2023

Background:

Neuroinflammation and oxidative stress after traumatic brain injury (TBI)
can further lead to neuronal apoptosis, which plays a crucial role in the process of neuron death.
Curcumin, which is derived from the rhizome of the Curcuma longa plant, has multiple pharmacological
effects.

Objective:

The objective of this study was to investigate whether curcumin treatment has neuroprotective
effects after TBI, and to elucidate the underlying mechanism.

Methods:

A total of 124 mice were randomly divided into 4 groups: Sham group, TBI group,
TBI+Vehicle group, and TBI+Curcumin group. The TBI mice model used in this study was constructed
with TBI device induced by compressed gas, and 50 mg/kg curcumin was injected intraperitoneally
15 minutes after TBI. Then, the blood-brain barrier permeability, cerebral edema, oxidative
stress, inflammation, apoptosis-related protein, and behavioral tests of neurological function
were utilized to evaluate the protective effect of curcumin after TBI.

Results:

Curcumin treatment markedly alleviated post-trauma cerebral edema and blood-brain
barrier integrity, and suppressed neuronal apoptosis, reduced mitochondrial injury and the expression
of apoptosis-related proteins. Moreover, curcumin also attenuates TBI-induced inflammatory
response and oxidative stress in brain tissue and improves cognitive dysfunction after TBI.

Conclusion:

These data provide substantial evidence that curcumin has neuroprotective effects in
animal TBI models, possibly through the inhibition of inflammatory response and oxidative stress.
Isolated Mitochondrial Preparations andIn organelloAssays: A Powerful and RelevantEx vivoTool for Assessment of Brain (Patho)physiology
Authors: Ahmad Faraz , Ramamorthy Siva , Areeshi Mohammed Y. , Ashraf Ghulam Md. , Haque Shafiul
Published: March 2023

Mitochondria regulate multiple aspects of neuronal development, physiology, plasticity, and pathology through their regulatory roles in bioenergetic, calcium, redox, and cell survival/death signalling. While several reviews have addressed these different aspects, a comprehensive discussion focussing on the relevance of isolated brain mitochondria and their utilities in neuroscience research has been lacking. This is relevant because the employment of isolated mitochondria rather than their in situ functional evaluation, offers definitive evidence of organelle-specificity, negating the interference from extra mitochondrial cellular factors/signals. This mini-review was designed primarily to explore the commonly employed in organello analytical assays for the assessment of mitochondrial physiology and its dysfunction, with a particular focus on neuroscience research. The authors briefly discuss the methodologies for biochemical isolation of mitochondria, their quality assessment, and cryopreservation. Further, the review attempts to accumulate the key biochemical protocols for in organello assessment of a multitude of mitochondrial functions critical for neurophysiology, including assays for bioenergetic activity, calcium and redox homeostasis, and mitochondrial protein translation. The purpose of this review is not to examine each and every method or study related to the functional assessment of isolated brain mitochondria, but rather to assemble the commonly used protocols of in organello mitochondrial research in a single publication. The hope is that this review will provide a suitable platform aiding neuroscientists to choose and apply the required protocols and tools to address their particular mechanistic, diagnostic, or therapeutic question dealing within the confines of the research area of mitochondrial patho-physiology in the neuronal perspective.
Insights on Microsomal Prostaglandin E2 Synthase 1 (mPGES-1)
Inhibitors using Molecular Dynamics and MM/PBSA Calculations
Authors: dos Santos  Nascimento Igor José , de  Aquino Thiago Mendonça , da Silva Júnior Edeildo Ferreira , de  Moura Ricardo Olimpio
Published: March 2023

Background:

Despite being a normal body response against invading agents, inflammation,
when exaggerated, needs to be controlled to minimize damage to the body. There are several drugs in
clinical use against inflammation and other inflammatory conditions. Still, side effects often limit the use
of these drugs, such as gastrointestinal effects generated by COX-1 inhibitors and cardiovascular effects
by COX-2 inhibitors. Thus, exploring new targets such as mPGES-1 may lead to discovering agents that
are more selective against inflammation and generate fewer side effects.

Objectives:

Here, docking, molecular dynamics, and MM-PBSA studies were performed on a dataset of
known mPGES-1 inhibitors to identify helpful information and discover new mPGES-1 inhibitors.

Methods:

Molecular docking in GOLD software was used to obtain the complexes used in Molecular
dynamics simulations (GROMACS software), performed to generate the RMSD, RMSF, Rg, SASA, and
H-bond plots to predict the complexes' stability. The most stable conformation was analyzed regarding
the most important interactions of the compounds. Finally, MM-PBSA calculations using the tool
g_mmpbsa in GROMACS software were performed to determine de-binding affinity, interaction parameters,
and per-residue contribution.

Results:

The main findings of this work were that the molecular dynamics simulation was able to find the
open conformation of mPGES-1, which showed a greater preference on compounds in this region, consisting
of residues known as "gateways". All compounds showed stability and stable complex formation
with mPGES-1, as demonstrated by the results of RMSD, RMSF, Rg, SASA, and H-bond plots generated
in a molecular dynamics simulation at 100 ns. The molecular dynamics identified three preferential sites
of interaction for the compounds. Thus, the docking and dynamics protocols showed greater affinity of
these compounds for cavity-02, interacting with Leu85, Pro81, Gln134, Cys137, Ala138, and Ala141. On the
other hand, compound 09 preferred the cavity-03 of the protein, interacting mainly with His72 through Hbond.
In addition, MM-PBSA calculations showed binding energies of up to -220,113 KJ/mol for compound
04. Furthermore, MM-PBSA could identify which electrostatic interactions are the most prevalent
in the complex formation of the compounds with the highest affinity (04 and 07). Still, the van der Waals
interactions are the most important for the others. Finally, the energy contribution per-residue revealed
Lys120, Arg122, Arg126, and Tyr130 as the most important for the formation of the complexes.

Conclusion:

Design mPGES-1 inhibitors based on the residues Leu85, Pro81, Gln134, Cys137, Ala138, and
Ala141, in addition to Lys120, Arg122, Arg126, and Tyr130 can provide new promising drugs useful against
diseases involving inflammatory conditions.