bluuebunny/crossref_metadata_2025 huggingface dataset:
A dimensão espiritual no pensamento de Viktor Frankl e suas implicações sociopolíticas
Authors: Aquino Thiago Antonio Avellar de
Published: January 2020

O presente artigo tem por objetivo identificar as implicações sociopolíticas da dimensão espiritual no pensamento de Viktor Frankl. Para tanto, realizou-se uma revisão da literatura tendo por base as principais obras do autor. Constatou-se que a dimensão sociopolítica foi um objeto de suas preocupações e que em seus manuscritos podem-se apontar diretrizes para a compreensão e resolução dos conflitos nos tempos atuais. Discute-se ainda o papel da comunidade na valorização da dignidade humana e a sua relevância para superar a massificação e o processo de despersonalização.
Peregrinação entre tradição e modernidade: contributos para uma classificação
Authors: Santos Maria da Graça Mouga Poças
Published: January 2020

O objetivo principal deste texto será, para além da tentativa de definir o que se entende por peregrinação, a apresentação de uma sistematização de diferentes tipos de peregrinações históricas ou subsistentes, sendo certo que cada uma delas pode abarcar mais do que uma modalidade. Assim, será possível abordar e caracterizar de uma forma mais abrangente a diversidade de que se reveste esta prática. Com base num conjunto de critérios selecionados, procura-se abordar a temática, simplificando a compreensão da realidade assaz complexa que o fenômeno da peregrinação traduz na atualidade.
FATOR ANTHROPO-DEMONÍACO: UM DESDOBRAMENTO MUNDANO DA CONTRIBUIÇÃO DE FREYTAG PARA O ESTUDO DAS RELIGIÕES
Authors: Bernardo Carlos Eduardo
Published: January 2020

O presente artigo consiste em uma breve reflexão sobre a prática do mal no interior de religiões que pregam o bem. Trata-se de um questionamento sobre o que leva pessoas, inclusive líderes espirituais, a praticarem atos vis, abusos psicológicos e físicos contra membros de suas famílias, comunidades e outras pessoas que procuram, na religião, o consolo, a força e a esperança para continuarem a viver. Este escrito pretende também contribuir como um esboço de uma “teoria da vontade” aplicada à fenomenologia da vida religiosa. É uma inquirição acerca da pertinência da religião quando essa parece perder, em nossos dias, a sua capacidade transformadora ou se tornar impotente diante dos mais baixos instintos humanos. Esta reflexão busca correlacionar uma abordagem originalmente teológica com um problema ético. Entretanto, ambiciona fazer esse exercício de pensamento sem desligar, em absoluto, as raízes originárias do campo metafísico. Por fim, intenta olhar a partir de uma perspectiva da filosofia antropológica, portanto confessadamente “mundana” e limitada, para um problema que, em primeira instância, parece interessar principalmente aos teólogos e religiosos, mas que, por envolver uma esfera da vida que, de certo modo, abarca toda a humanidade, suscita a reflexão em todo aquele que se reconhece ligado com a humanidade, inclusive no sofrimento.
ABRAÃO E A FÉ PARADIGMÁTICA: DA RELAÇÃO ABSOLUTA COM O ABSOLUTO À ENCARNAÇÃO DO ABSOLUTO NO DEUS-HOMEM JESUS CRISTO
Authors: Mariano da Rosa Luiz Carlos
Published: January 2020

Investigando o dever ético do Herói Trágico e a sua virtude moral em um processo que envolve o sacrifício ao geral e sobrepõe o universal ao singular, o artigo, baseado na perspectiva teológico-filosófica de Kierkegaard, estabelece a distinção entre Agamêmnon e Abraão, o Cavaleiro da Fé e a sua relação absoluta com o Absoluto, por meio de um ato que o mantém para além do geral e da sua mediação e implica a suspensão temporária do ético em um movimento de resignação infinita, em face do dever absoluto que converge para o paradoxo absoluto da fé e encerra a espiritualidade individual como base da existência autêntica. Dessa forma, assinalando a superação do desafio do desespero da relação envolvendo o princípio moral e a ordem de Deus em uma experiência existencial que engendra a espiritualidade individual e a consciência da singularidade, o artigo sublinha o processo que torna Abraão pai espiritual de todo aquele que crê e que, tendo como fundamento a leitura teológico-bíblica e católico-protestante, demanda a manifestação do Deus-Homem Jesus Cristo como a encarnação do Lógos, em um movimento que pressupõe um novo ser e um novo modo de existência e atribui à fé a condição de que “tudo é possível”, seja para Deus, seja para o homem.
Busca da verdade versus ideologia no Acontecimento José Comblin
Authors: Ottaviani Edelcio
Published: January 2020

Este artigo, fruto de uma fala na mesa intitulada “Teologias e Ideologias” da I Jornada José Comblin, em uma parceria entre PUC-SP e UNICAP, parte de uma definição preliminar de ideologia, trabalhada por Marilena Chauí (1941) no rastro de Karl Marx (1818-1883). Em seguida, abre espaço à sutileza de nosso teólogo ao analisar as ideologias que permearam três momentos significativos de sua vida, nos quais ele critica a ideologia religiosa, a ideologia política e a ideologia econômica, muito embora, ao salientar cada uma delas, ele não exclua a influência de uma sobre as outras. Por fim, apresenta a vida e a obra de José Comblin como uma ontologia crítica do presente, no dizer de Foucault, e um modo de ser na verdade, retirando as máscaras das ideologias que se esforçam por fechar nossos olhos a uma leitura mais ampla da realidade.
Dom e Carisma na economia: reflexões a partir do pensamento de Chiara Lubich
Authors: Fernandes Marcio Luiz , De Santana Cleiton Costa
Published: January 2020

O presente artigo versa sobre a busca de critérios e motivações econômicas que contrastem com a lógica instrumental predominante nos dias de hoje. O nosso percurso teórico partirá da distinção entre economia formal e substantiva, conforme enunciada por Karl Polanyi, passará pela crítica à lógica utilitarista, chegando à exigência do resgate de critérios em desuso, como o dom e a reciprocidade, presentes nos carismas. Aproximamo-nos, assim, do carisma e do pensamento de Chiara Lubich, perscrutando nesses os elementos antropológicos e a lógica relacional que sejam capazes de infundir a economia. Entendemos que, como realidade comunitária, o carisma engendra e fortalece, nas relações, a dinâmica do dom, sendo, assim, capaz de realocar a lógica instrumental para aquelas relações que são estritamente instrumentais. Por fim, apresentamos a Economia de Comunhão como exemplo concreto de realização econômica que busca estabelecer novas formas de pensar e agir na economia.
A ternura: o grande projeto revolucionário
Authors: Fretto Luis , Souza Waldir
Published: January 2020

Vive-se numa época em que a humanidade está habituada as notícias cruéis e desumanas, na qual prevalece a produção e o comércio de armas, gerando vários tipos de violências. Enfim, tornou-se um lugar onde impera a lei do mais forte, a barbárie, uma lei que distribui inumanidade, adequada ao molde dos egoísmos particulares. Em múltiplas faces ideológicas que prometem soluções rápidas, a violência se torna explícita numa sociedade frágil e totalmente vulnerável. Porém, se existe na sociedade o lado assustador da violência, também aparece a profunda solidariedade e cooperação que são continuamente destacadas no convívio social. Este artigo apresenta um elemento próprio ao ser humano, a ternura, que, a partir de sua conscientização, apresenta-se como solução harmoniosa e afetiva nas diferentes divergências referentes ao âmbito da convivência humana. Nessa perspectiva, propõe-se um projeto revolucionário, “que possa colocar as pessoas de novo no centro”, renovando a esperança de um futuro feliz, fruto da amabilidade, gentileza e civilidade. O objetivo deste artigo é expressar com clareza a relevância da “ternura” como elemento primordial de justiça, que sabe distinguir o bem do mal e que nos impulsiona, por meio da solidariedade, ao resgate da dignidade do outro atingido pela fragilidade humana. A metodologia utilizada foi a pesquisa qualitativa bibliográfica. Analisou-se o sentimento da ternura a partir de um estudo antropológico, cujos conteúdos, somados a experiência da fé, lançam luzes sobre o valor teológico. Espera-se que a sociedade do terceiro milênio evidencie, no lugar de uma cultura da violência alimentada pelo egoísmo e a morte, uma cultura da ternura, de amor e de vida. Somente assim, sob a condição do reencontro com o sentido da ternura, poder-se-á inverter o triunfalismo das ideologias, do iluminismo, pelo sentido da hospitalidade, da valorização, da diferença, do respeito amoroso da natureza e do ambiente.
Racial Migrations
Authors: Hoffnung-Garskof Jesse E.
Published: January 2020

In the late nineteenth century, a small group of Cubans and Puerto Ricans of African descent settled in the segregated tenements of New York City. At an immigrant educational society in Greenwich Village, these early Afro-Latino New Yorkers taught themselves to be poets, journalists, and revolutionaries. At the same time, these individuals built a political network and articulated an ideal of revolutionary nationalism centered on the projects of racial and social justice. These efforts were critical to the poet and diplomat José Martí's writings about race and his bid for leadership among Cuban exiles, and to the later struggle to create space for black political participation in the Cuban Republic. This book presents a vivid portrait of these largely forgotten migrant revolutionaries, weaving together their experiences of migrating while black, their relationships with African American civil rights leaders, and their evolving participation in nationalist political movements. By placing Afro-Latino New Yorkers at the center of the story, the book offers a new interpretation of the revolutionary politics of the Spanish Caribbean, including the idea that Cuba could become a nation without racial divisions. A model of transnational and comparative research, the book reveals the complexities of race-making within migrant communities and the power of small groups of immigrants to transform their home societies.
Demography
Authors: Andersen Ken H.
Published: January 2020

This chapter shows how the population size spectrum can be calculated using the vital rates of the individuals within the population: the growth rate, the reproduction rate, and the mortality as functions of size. It discusses the physiological mortality at length, and attempts to estimate its value from meta-analyses of mortality and growth rate in fish. In obtaining solutions of the population size spectrum, the chapter follows two parallel tracks: a simplified analytical solution, and a full numerical solution. The analytical solution offers insights into the governing scaling relationships between asymptotic size and population-level measures, such as spawning stock biomass, reproductive output, and lifetime reproductive output. Meanwhile, the numerical solution allows us to explore the effects of size-based fishing in the next chapter.
Teleosts versus Elasmobranchs
Authors: Andersen Ken H.
Published: January 2020

This chapter looks into the differences and similarities between the two groups of fish: the teleosts and the elasmobranchs. In the data analyses done so far in this volume, the fish most considered were the teleosts (Teleostei), which represent by far the dominant group, in terms of both biomass and living number of species. Second in line comes the cartilaginous fishes—the elasmobranchs (sharks, rays, skates, and sawfish). This chapter describes the differences between teleosts and elasmobranchs from a population dynamics perspective. It shows that the main difference between the two groups is in their offspring size strategy: teleosts make small offspring; elasmobranchs make large offspring. The chapter uses this difference to quantify the sensitivity of elasmobranchs to fishing relative to teleosts. It also develops an evolutionary explanation for why the offspring size strategy differs between teleosts and elasmobranchs.
Consumer-Resource Dynamics and Emergent Density Dependence
Authors: Andersen Ken H.
Published: January 2020

This chapter focuses on a generalization of a classic consumer-resource model with a single population embedded in a community. It develops this physiologically structured consumer-resource model by extending the static model in Chapter 4. The chapter then studies how density dependence emerges in the model, and how it changes the population size spectrum. Finally, the chapter explores how some of the standard fisheries impact assessments from Chapter 5 are changed when density dependence is in the form of competition or cannibalism. Specifically, it shows how the appearance of late-life density dependence rocks one of the cornerstones of contemporary fisheries management: that we should fish only the largest fish. In some cases, it turns out that yield is instead maximized by fishing juveniles.
Assured Newcomers on a Squally Sea? The Czech Pirate Party before and after the 2017 Elections
Authors:   Charles University, Czech Republic, Šárovec Daniel
Published: January 2020

The elections to the Chamber of Deputies in October 2017 were a turning point for the Czech Pirate Party (called “Piráti”). It was the first time since establishing the party in 2009 that the Pirates entered the lower house of the Czech Parliament. They took the third place with 10.79 % votes and won 22 seats out of 200. Their main programme points came out of typical “pirate policies” like control of power and the powerful ones, simplification of the running of the state through technology, protection of citizens from bullying and defence of freedom as well as basic Pirate principles including liberalism and direct democracy. Their programme was called “New Ideas for the New Age”. From a different view, this party presented itself as a watchdog of democracy and as an alternative mostly for liberal voters. This qualitative case study will provide a complex overview of the Pirate phenomenon in the Czech Republic from their establishment to their current role of an opposition party. This article aims to show and describe how the position of the Czech Pirates has varied over time. For this purpose, open data from the Czech Statistical Office (CZSO) and the findings from the Chapel Hill Expert Survey (CHES) dataset will be used. It is possible to say that the Pirates are playing the role of newcomers in the Chamber of Deputies after the 2017 elections, but they are not newcomers in the Czech party system.
Elena Redondo-Moyano y María José García Soler (eds.), Nuevas interpretaciones del Mundo Antiguo. Papers in Honor of Professor José Luis Melena on the Occasion of his Retirement, Vitoria-Gasteiz, Veleia [Series minor 33], 2016, 369 pp., ISBN 978-84-9082-4
Authors: Canzobre Martínez Isabel
Published: January 2020

Elena Redondo-Moyano y María José García Soler (eds.), Nuevas interpretaciones del Mundo Antiguo. Papers in Honor of Professor José Luis Melena on the Occasion of his Retirement, Vitoria-Gasteiz, Veleia [Series minor 33], 2016, 369 pp., ISBN 978-84-9082-481-8
Hacia una poética aporética: de la interpretación a la traducción en cuatro pasajes de En Defensa de Palamedes de Gorgias
Authors: Chialva Ivana Selene
Published: January 2020

En Defensa de Palamedes de Gorgias es un texto que reúne, simultáneamente, voces complementarias y antagónicas: voces de la retórica escolar, del drama, de la filosofía, de la sofística y de la política de finales del siglo V a.C. en Atenas. Otro rasgo particular es el tratamiento del discurso del héroe cuya retórica puede representar la tragedia comunicativa del lenguaje o su superación. En este trabajo presentaremos algunas problemáticas del texto gorgiano a la luz de dos instancias que se implican pero no siempre se condicen: la traducción y la interpretación crítica. A partir del criterio de traducción de la “letra” de Berman (1991), se analizarán pasajes de diferentes versiones italianas del texto: Untersteiner (1949), Mazzara (1999), Mariani (2010) y Giombini (2012).
Luna como tópico. Propuesta de un proyecto de enseñanza–aprendizaje para futuros docentes en las didácticas de la literatura y las ciencias experimentales
Authors: Gómez Redondo Susana , Paramá Díaz Anabel
Published: January 2020

Proponemos un proyecto de enseñanza-aprendizaje en el aula de Educación Superior, con la Luna como tópico vertebrador. Destinado a futuros docentes, la propuesta implica dos didácticas específicas, la literaria y de las ciencias experimentales, y pretende servir de investigación didáctica y metadidáctica, a la vez que proporcionar herramientas y métodos susceptibles de trasladar al aula de Primaria. La ciencia ficción (en esta ocasión la cinematográfica) se revela como ámbito excepcional para trabajar transdisciplinarmente los contenidos curriculares contemplados en estas dos materias. La idea es que el alumnado experimente enfoques como el Aprendizaje Basado en Proyectos (ABP), el cooperativismo, el enactivismo o el conectivismo, y, en línea con la tradición reflexiva de la didáctica y su circularidad teórico-práctica, reflexione en torno a ellos y explicite lo que hemos denominado sus representaciones sociodidácticas implícitas (RSI).
Soledad, identidad y medios de (in)comunicación en Volver a casa de Juan José Millás
Authors: Sevillano Canicio Victor
Published: January 2020

El artículo analiza el papel de los medios de comunicación (cartas, radio, televisión y teléfono) en la novela Volver a casa de Juan José Millás, que trata del tránsito e intercambio de identidades entre dos hermanos gemelos.  El lector se ve enfrentado a un seguido de utilización de medios de comunicación que se revelan ser  elementos cruciales de intercomunicación en el entramado que se mueve entre ficción y metaficción, así como el proceso de construcción y deconstrucción del personaje central Juan. Los medios de comunicación, todavía analógicos de la última época de la era pre-digital, no sólo tienen la función de hacer posible la comunicación social pero sirven también para encubrir el engaño, infundir miedo y dañar la percepción de la propia identidad. Es ese aspecto problemático de los medios de comunicación en el que se centra el trabajo.
Camilo José Cela, entre el teatro y el ensayo: Homenaje al Bosco II (1999)
Authors: Guimerà Galiana Alba
Published: January 2020

El teatro de Cela resulta una rareza en el panorama literario español muy poco estudiada por la crítica. El escritor gallego ofrece un teatro con un sello muy propio, a caballo entre la tradición española y la modernidad de las Vanguardias europeas. Se muestra marcadamente rupturista, experimental e innovador, al tiempo que bebe de la tradición del esperpento o incluso del clasicismo grecolatino, añadiendo a todo ello como telón de fondo, la crudeza de su ya característico -y mal llamado- tremendismo y un abanico interminable de lecturas que forman parte de sus aprendizajes literarios y de su personalidad como escritor. Homenaje a El Bosco II (Seix Barral, 1999), su última obra dramática, tiene la voluntad de ser una síntesis de la historia de España desde la pérdida de Cuba y Filipinas, en 1898, hasta el triunfo de Franco en la Guerra Civil, a pesar de que en la obra se insista en que “esto no es un tratado de historia ni un manual de buenas costumbres”. En efecto, se trata de un gran guignol -diremos- “neoesperpéntico”, conducido en gran parte por lo que el escritor denominó “las cuatro columnas del 98”: Valle-Inclán, Unamuno, Baroja y Azorín. Cela demuestra de nuevo, como ya hizo anteriormente en numerosos ensayos, ser un gran lector del 98 y muy especialmente de la literatura y el pensamiento de estas cuatro figuras axiales.
Spatio-Temporal Change of Land Surface Temperature at Tiris Geothermal Potential Area, East Java, Indonesia.
Authors: Prayogo Andre , Maryanto Sukir , Nadhir Ahmad
Published: January 2020

One of the areas that have geothermal potential in Indonesia is Tiris because there are found some manifestation in the form of hot springs. Several studies are needed to determine its geothermal potential before exploitation is carried out. Some previous studies have been carried out in the area, one of which uses Landsat 7 remote sensing data. There are other studies that state that knowledge of geology is needed to implement remote sensing in determining geothermal areas. This study uses 3-years data from Landsat 8 and geological information from the regional geological map of the study area. The result show changes in the value of Normalized Difference Vegetation Index (NDVI) and Land Surface Temperature (LST) from year to year, where each year the NDVI value decrease which is interpreted as reduced vegetation in the study area. From the distribution of LST values in the study area, it was found that there were hot spots that had higher temperatures than the surrounding area. When geological information and LST distribution map overlaid with regional geological maps, it is known that the hot spots inside the research area are possible to be a geothermal reservoir.
Delineation of Stratigraphic Units in Xyz Field of Niger Delta Using Geophysical Logs
Authors: Ekeh Charles C. , Uko Etim D. , Eleluwor Ejiro F. , Sigalo Friday B.
Published: January 2020

Geophysical well logs were used to delineate the stratigraphic units and system tracks in the XYZ Field of the Niger Delta. The gross percentages for sand levels range from 93-96% in the shallow levels to 60-66% in the deeper levels. Porosity values ranged between 27% at shallower sections and 9% at deeper depths. Six depositional sequences were identified and categorized into their associated system tracts. Porosity decreases with depth in normal compacted formation for both sandstone and shale units. Surface porosity for sandstone is 42%, and for shale it is 38.7% from extrapolation of sub-surface porosity values to the surface. The depth to the base of Benin Formation is highly variable ranging between 1300 and 2600m. This study reveals the possibility to correlate sand levels over long distances which enables inferring porosity values laterally. The knowledge of the existent stratigraphic units, the Benin, Agbada and Akata Formations and their petrophysical parameters such as porosity, lateral continuity of the sands and shales, the variation of the net-to-gross of sands with depth, enables the reservoir engineer to develop a plan for the number and location of the wells to be drilled into the reservoir, the rates of production that can be sustained for optimum recovery. The reservoir engineer can also estimate the productivity and ultimate recovery (reserves) using the results on this work.
Pertanggungjawaban Pidana Perusahaan Teknologi atas Tindak Pidana Kecelakaan Lalu Lintas oleh Pengemudi Ojek Online
Authors: Kumala Sari Ratna , Putra Jaya Nyoman Serikat
Published: January 2020

Act No. 22 the year 2009 about Lalu Lintas dan Angkutan Jalan (road traffic and transportation) raises perspectives in criminal law regarding criminal liability for public transportation companies. Furthermore, it raises problems on how criminal liability of technology companies for traffic accidents and how law enforcement practice. The purpose of this study is to analyze and describe the criminal liability of technology companies for traffic accident by online motorcycle taxi drivers and for criticizing law enforcement. Normative research methods will be used to answer the problem. There are two approaches to assess the problem, namely case approach the and law approach. The conclusion is that technology companies can be criminally accounted for by the vicarious liability perspective and the Road Traffic and Transportation Act.

Undang-Undang No. 22 Tahun 2009 tentang Lalu Lintas dan Angkutan Jalan (UULLAJ) memunculkan perspektif dalam hukum pidana menyangkut pertanggungjawaban pidana bagi perusahaan angkutan umum. Selanjutnya memunculkan permasalahan mengenai bagaimana pertanggungjawaban pidana perusahaan teknologi atas tindak pidana kecelakaan lalu lintas dan bagaimana praktek penegakan hukumnya. Tujuan penelitian ini untuk menganalisis dan mendeskripsikan mengenai pertanggungjawaban pidana perusahaan teknologi atas tindak pidana kecelakaan lalu lintas oleh pengemudi ojek online dan untuk mengkritisi penegakan hukumnya. Metode penelitian normatif yang akan digunakan untuk menjawab permasalahan ini. Terdapat dua pendekatan untuk mengkaji permasalahan ini yaitu pendekatan kasus dan pendekatan undang-undang. Dari hasil pembahasan dapat disimpulkan bahwa perusahaan teknologi dapat dipertanggungjawabkan secara pidana dengan perspektif vicarious liability dan Undang-Undang Lalu Lintas dan Angkutan Jalan.
Foreigners and Narcotics Crimes: How Indonesian Laws Determine the Supervision Mechanism?
Authors: Kartika I Gusti Ayu , Setiabudhi I Ketut Rai , Winarsi Sri
Published: January 2020

Oversight of foreigners becomes very important in line with the increase in international crime, one of which is a narcotics crime. Through technological developments, the spread of narcotics has reached almost all regions in Indonesia. The state does not want its territory to have people involved in narcotics crimes. The main objective of the supervision of foreigners is to protect the community and the sovereignty of the State. The aim of the study to analyze who has authorized to conduct surveillance of foreigners related to narcotic crimes. This research is a normative legal research using the legislation approach and concept approach. The results of the research are: The authority to supervise foreigners related to narcotics criminal acts based on the Immigration Act is carried out by the Minister by forming a team consisting of relevant government agencies or agencies both at the central and regional levels. The institution is the Immigration Agency and is also carried out by the National Narcotics Agency which coordinates with the Police. Furthermore, based on the Law on narcotics that is authorized to conduct surveillance of Narcotics crime as regulated under the provisions of Article 61 paragraph (1) is the Government. The government supervises all activities related to Narcotics.. Oversight of Foreigners related to narcotics crime, is not only done when they enter, but also while they are in the Territory of Indonesia, including their activities. Immigration Supervision covers the enforcement of immigration law, both administrative and Immigration.
The potential utility of real-time PCR of the 16S-rRNA gene in the diagnosis of neonatal sepsis
Authors: İstanbullu Kenan , Köksal Nilgün , Çetinkaya Merih , Özkan Hilal , Yakut Tahsin , Karkucak Mutlu , Doğan Haldun
Published: January 2020

The purpose of this study was to evaluate the efficacy of real-time polymerase chain reaction (PCR) of the 16S rRNA gene in diagnosis of neonatal sepsis and compare it with conventional blood culture. A total of 150 infants were enrolled in this prospective study. The infants were classified into two groups: sepsis group (n=100) and control group (n=50). Blood samples for complete blood count, C-reactive protein, procalcitonin, serum-amyloid A, blood culture and PCR were obtained before initiating antibiotic treatment. Eight specific probes were used to perform PCR analysis for detection of 8 different microorganisms. The positivity rates of blood culture and PCR were found as 11% and 3%, respectively. The diagnosis of neonatal sepsis by PCR revealed a 16.6 % sensitivity, 97.8 % specificity, 33.3% positive predictive value and 94.8% negative predictive value compared with the blood culture. This study showed a low sensitivity of PCR of the 16S rRNA gene in the diagnosis of neonatal sepsis. This may be associated with the identification of rare microorganisms in the blood culture that were not included to PCR analysis. Implementation of all suspectible microorganisms into PCR assay may increase the sensitivity of 16S rRNA gene PCR in diagnosis of neonatal sepsis.
Cranial MR characteristics of Cerebral Palsy cases and correlation of findings with clinical results
Authors: Ali Asuman , Yalçın Ramazan , Ünlüer-Gümüştaş Ayşem
Published: January 2020

The aim of this study was to compare cranial Magnetic Resonance (MR) imaging findings in cerebral palsy (CP) patients with clinical findings and evaluate damage ascribed to prenatal, natal and postnatal reasons by preterm, term or postterm characteristics. One thousand, one hundred CP patients registered at Dr. Ayten Bozkaya State Hospital of Cerebral Palsy Children and Rehabilitation Center from 2007 to 2010 were included in the study retrospectively. Cranial MR images studied in Bursa State Hospital Radiology Unit were evaluated by `a single senior MRI radiologist`. The most common abnormality was cerebral atrophy (80.2%) followed by periventricular leukomalacia (PVL) (49.9%). The most common type was spastic tetraplegia (67.9%), and the second most common type was hypotonic CP (15.6%). The percentage of congenital central nervous system (CNS) abnormality was 14.09%. The most common abnormality was corpus callosum (CC) agenesis and colpocephaly (2.3%). The least common conditions were cortical dysplasia, heterotopia and rhombencephalosynapsis. The percentage of cases born to consanguineous parents was 19.2%. In Hypoxic Ischemic Encephalopathy (HIE) patients born to consanguineous parents, PVL was cystic and moderate. Consanguineous marriage was statistically significant in the patients with cortical dysplasia and heterotopia (p < 0.04), delay in myelination (p < 0.001) and thalamus involvement (p < 0.008). Consanguineous marriage was also statistically significant in spastic diparetic (p < 0.017), hypotonic (p < 0.001) and bedridden patients (p < 0.006). The presence of both congenital CNS anomaly and PVL was only revealed in spastic tetraparetic type. Twentynine% of the cases were premature, while 66.4% were term children. Low birth weight (32.7%) constituted a risk factor for all clinical types, except mixed type CP. The percentage of patients with natal causes only was 21.5%. Kernicterus, cerebrovascular causes and HIE accounted for 6.3%, 2.9% and 54.4% of the cases, respectively. This study may indicate the importance of consanguineous marriage, natal and postnatal care properties as the underlying causes of CP beyond the clinical management related to delivery and allow us to identify strategies for possible measures.
Impulse oscillometry reference values and correlation with predictors in Turkish preschool children
Authors: Er İlkay , Günlemez Ayla , Baydemir Canan , Kılıçbay Fatih , Ersu Refika , Uyan Zeynep Seda
Published: January 2020

Impulse oscillometry (IOS) is a noninvasive, rapid technique requiring passive cooperation that allows for evaluation of lung function through the measurement of airway resistance and reactance. There are no available reference values for Turkish children. This study is aimed to determine the reference values of IOS parameters and to study their correlation with height, weight, body mass index, and age as predictors in healthy Turkish preschool children. Healthy children between 3-7 years of age who were selected according to ERS/ATS criteria and followed at Kocaeli University outpatient clinic performed IOS. The correlation between the anthropometric predictor variables and resistance and reactance at 5-20 hertz (R5-R20 and X5-X20), the respiratory impedance at 5 hertz (Z5), resistance area (AX) and resonance frequency (Fres) were assessed by regression analysis and stepwise method. 151 children (93 female) with the mean age of 67.9±16.2 months participated in the study. Multilinear regression analysis for IOS values of all children revealed that resistance was significantly correlated with height and reactance was significantly correlated with age (p < 0.05). For girls, height had a negative effect on R5-20, Z5, AX values, while age had a positive effect on X5-20 and a negative effect on Fres (p < 0.05). For boys, weight had a negative effect on R5- 20, Z5 values, while age had a positive effect on X15-20 and a negative effect on AX, Fres (p < 0,05). This study provided reference values of IOS in healthy Turkish children that would be a useful guide for diagnosing and following respiratory diseases in preschool children.
Unusual and early onset IPEX syndrome: a case report
Authors: Doğruel Dilek , Gürbüz Fatih , Turan İhsan , Altıntaş Derya Ufuk , Yılmaz Mustafa , Yüksel Bilgin
Published: January 2020

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare disorder that causes systemic autoimmunity resulting from a mutation of the forkhead box protein 3 gene (FOXP3). A 2-year-old boy, was referred to the hospital due to vomiting and fever when he was 21 days old. On physical examination the patient was severely dehydrated, and his laboratory test results showed hyperglycemia and metabolic acidosis. Upon the continuance of the hyperglycemia which caused the patient to receive permanent insulin treatment, the patient was diagnosed with neonatal diabetes mellitus. Here, we report a 2-year-old boy with early-onset IPEX syndrome due to a c.1040G > A (p.R347H) mutation in exon 11 of the FOXP3 gene. Although the patient had missense mutation in his FOXP3 gene, he did not have other immunodysregulation symptoms. IPEX syndrome should be kept in mind in all the cases of associated neonatal diabetes mellitus in male neonates or infants.
Semi-invariant lightlike submanifolds of golden semi-Riemannian manifolds
Authors: (ÖNEN) POYRAZ Nergiz , DOĞAN Burçin
Published: January 2020

In this study, we introduce semi-invariant lightlike submanifolds of golden semi-Riemannian manifolds. We find some conditions for integrability of distributions. Morever, we investigate totally geodesic and mixed geodesic distributions of such a submanifold. The paper also contains an example.
Congenital absence of a lumbosacral facet joint: A case report
Authors: Adsul Nitin Maruti , Kumar Manoj , Acharya Shankar , Kalra K. L. , Chahal R. S.
Published: January 2020

Background:

Congenital absence of the lumbosacral facet joint is extremely rare, with only 26 cases reported in the literature. Here, we present a patient with the unilateral absence of the left fifth lumbar inferior articular process and reviewed the relevant literature.

Case Description:

A 32-year-old gentleman, who had undergone right L4-5 lumbar microdiscectomy 3 months ago now presented with acute low back and left leg pain following a fall. He is now presented with acute low back and left leg pain following a fall. Plain radiographs of the L-S spine revealed an absent left L5–S1 zygapophyseal joint. The magnetic resonance imaging and computed tomography studies additionally confirmed an absent unilateral left L5 lumbar inferior articular process.

Conclusion:

Patients presenting for lumbar surgery may have unilaterally absent lumbosacral zygapophyseal joints, which may impact the outcome of surgical treatment.
COLLABORATION OF THE ETHNOBOTANY MATERIALS WITH THE ENVIRONMENTAL CARE ATTITUDE OF STUDENTS
Authors: Marlina Reni , Irwanti Muthia , Syamswisna Syamswisna , Novita Oktavianti Sri Andi
Published: January 2020

One of the traditional utilization forms using diverse plants was a self-care ritual, which was anciently previously found in the tradition performed by women in the Qadriyah Palace of Pontianak Sultanate. The self-care ritual was aimed to treat either health-related problems or common diseases. Therefore, this ethnobotany study of the women self-care ritual was purposely implemented through a folding poster media in the tenth-grade sub-material of Senior High Schools, regarding the utilization of biodiversity in the field of cosmetics and medicines. The learning activity was collaboratively carried out with the teachers, so that students can recognize and preserve the varieties of beneficial plants in their environmental surroundings. The class selected as the subject of this study was class of X IPA 2. The collaborative learning process took place in two meetings; beginning with plan 1, performance 1, reflection 1; and plan 2, performance 2, and reflection 2 simultaneously in each meeting, with a duration of 90 minutes. The first cycle successfully implemented the ethnobotanic self-care-based folding poster media, previously performed by women in the Qadriyah Palace of Pontianak Sultanate’s environment, which had previously been validated by lecturers and teachers and was declared fit for use. Meanwhile, in the cycle 2, the media used was a flipbook. The results showed that collaborative learning using ethnobotany-based media can promote an environmental caring attitude amongst the tenth-grade students of SMAN 10 Pontianak.
QSPR Models for Predicting Critical Micelle Concentration of Gemini Cationic Surfactants Combining Machine-Learning Methods and Molecular Descriptors
Authors: Setiawan Ely , Mudasir Mudasir , Wijaya Karna
Published: January 2020

A data set of 231 diverse gemini cationic surfactants has been developed to correlate the logarithm of critical micelle concentration (cmc) with the molecular structure using a quantitative structure-property relationship (QSPR) methods. The QSPR models were developed using the Online CHEmical Modeling environment (OCHEM). It provides several machine learning methods and molecular descriptors sets as a tool to build QSPR models. Molecular descriptors were calculated by eight different software packages including Dragon v6, OEstate and ALogPS, CDK, ISIDA Fragment, Chemaxon, Inductive Descriptor, SIRMS, and PyDescriptor. A total of 64 QSPR models were generated, and one consensus model developed by using a simple average of 13 top-ranked individual models. Based on the statistical coefficient of QSPR models, a consensus model was the best QSPR models. The model provided the highest R2 = 0.95, q2 = 0.95, RMSE = 0.16 and MAE = 0.11 for training set, and R2 = 0.87, q2 = 0.87, RMSE = 0.35 and MAE = 0.21 for test set. The model was freely available at https://ochem.eu/model/8425670 and can be used for estimation of cmc of new gemini cationic surfactants compound at the early steps of gemini cationic surfactants development.
DenseCPD: Improving the Accuracy of Neural-Network-Based Computational Protein Sequence Design with DenseNet
Authors: Qi Yifei , Zhang John Z.H.
Published: January 2020

Computational protein design remains a challenging task despite its remarkable success in the past few decades. With the rapid progress of deep-learning techniques and the accumulation of three-dimensional protein structures, using deep neural networks to learn the relationship between protein sequences and structures and then automatically design a protein sequence for a given protein backbone structure is becoming increasingly feasible. In this study, we developed a deep neural network named DenseCPD that considers the three-dimensional density distribution of protein backbone atoms and predicts the probability of 20 natural amino acids for each residue in a protein. The accuracy of DenseCPD was 51.56±0.20% in a 5-fold cross validation on the training set and 54.45% and 50.06% on two independent test sets, which is more than 10% higher than those of previous state-of-the-art methods. Two approaches for using DenseCPD predictions in computational protein design were analyzed. The approach using the cutoff of accumulative probability had a smaller sequence search space compared to that of the approach that simply uses the top-k predictions and therefore enables higher sequence identity in redesigning three proteins with Rosetta. The network and the data sets are available on a web server at http://protein.org.cn/densecpd.html. The results of this study may benefit the further development of computational protein design methods.
Convolutional Network Analysis of Optical Micrographs
Authors: Smith Alexander , Abbott Nicholas L. , Zavala Victor M.
Published: January 2020

We provide an in-depth convolutional neural network (CNN) analysis of optical responses of liquid crystals (LCs) when exposed to different chemical environments. Our aim is to identify informative features that can be used to construct automated LC-based chemical sensors and that can shed some light on the underlying phenomena that governs and distinguishes LC responses. Previous work demonstrated that, by using features extracted from AlexNet, micrographs of different LC responses can be classified with an accuracy of 99%. Reaching such high levels of accuracy, however, required use of a large number of features (on the order of thousands), which was computationally intensive and which clouded the physical interpretability of the dominant features. To address these issues, here we report a study of the effectiveness of using features extracted from color images using VGG16, which is a more compact CNN than Alexnet. Our analysis reveals that features extracted from the first and second convolutional layers of VGG16 are sufficient to achieve a perfect classification accuracy on the same dataset used by Cao and coworkers, while reducing the number of features to less than a hundred. The number of features is further reduced to ten via recursive feature elimination with minimal loss in classification accuracy (5-10%). This feature reduction procedure reveals that differences in spatial color patterns are developed within seconds in the LC response. The results thus reveal that hue histograms provide an informative set of features that can be used to characterize LC micrographs of the sensor response. We also hypothesize that differences in spatial correlation length of LC textures detected by VGG16 with DMMP and water likely reflect differences in the anchoring energy of the LC on the surface of the sensor. This latter proposal hints at fresh approaches for the design of LC-based sensors based on characterization of spontaneous fluctuations in orientation (as opposed to changes in time-average orientation)
Β-Galactosidase-Catalyzed Fluorescent Reporter Labeling of Living Cells for Sensitive Detection of Cell Surface Antigens
Authors: Noguchi Katsuya , Shimomura Takashi , Ohuchi Yuya , Ishiyama Munetaka , Shiga Masanobu , Mori Takeshi , Katayama Yoshiki , Ueno Yuichiro
Published: January 2020

The ability to detect cell surface proteins using fluorescent dye-labeled antibodies is crucial for the reliable identification of many cell types. However, the different types of cell surface proteins used to identify cells are currently limited in number because they need to be expressed at high levels to exceed background cellular autofluorescence, especially in the shorter wavelength region. Herein, we report on a new method (CLAMP: quinone methide-based catalyzed signal amplification) in which the fluorescence signal is amplified by an enzymatic reaction that strongly facilitates the detection of cell surface proteins on living cells. We used β-galactosidase as an amplification enzyme and designed a substrate for it, called MUGF, which contains a fluoromethyl group. Upon removal of the galactosyl group in MUGF by β-galactosidase labeling of the target cell surface proteins, the resulting quinone methide group-containing product was found to be both cell membrane permeable and reactive with intracellular nucleophiles, thereby providing fluorescent adducts. Using this method, we successfully detected several cell surface proteins including programmed death ligand 1 protein, which is difficult to detect using conventional fluorescent dye-labeled antibodies.
Carboxylated Chitosan Nanocrystals: Novel Synthetic Route and Application as Superior Support for Gold-Catalyzed Reactions
Authors: Jin Tony , Kurdyla Davis , Hrapovic Sabahudin , Leung Alfred , Régnier Sophie , Liu Yali , Moores Audrey , Lam Edmond
Published: January 2020

Chitin nanocrystals (ChNCs) were prepared by partial cleavage of glycosidic bonds in chitin with concurrent oxidation of chitin C6 primary alcohols to produce carboxylate groups on the surface of the ChNCs. Following alkaline deacetylation of the ChNCs in the presence of NaBH4 to inhibit “end-peeling” afforded chitosan nanocrystals (ChsNCs) with a degree of deacetylation (DDA) >80%. Transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier-transform Infrared (FTIR) spectroscopy were used to determine the morphology and composition of these carboxylated ChNCs and ChsNCs. Subsequently, two methods were used to deposit Au onto the nanocrystals, and the catalytic activities of the resulting biomass-based nanocatalysts were tested for the 4-nitrophenol reduction and the aldehyde-amine-alkyne (A3) coupling reaction. In particular, Au nanoparticles over ChsNCs featured the highest turnover frequency value for the 4-nitrophenol reduction reported to date. Spectroscopic and imaging techniques confirmed the importance of controlling precisely the redox state of Au as it is being deposited to afford highly disperse active site on the bio-nano-support.
Simulation-Based Evaluation of Zeolite Adsorbents for the Removal of Emerging Contaminants
Authors: Fischer Michael
Published: January 2020

A number of experimental studies have evaluated the potential of hydrophobic high-silica zeolites for the adsorptive removal of emerging organic contaminants, such as pharmaceuticals and personal care products, from water. Despite the widespread use of molecular modelling techniques in various other fields of zeolite science, the adsorption of pharmaceuticals and related pollutants has hardly been studied computationally. In this work, inexpensive molecular simulations using a literature force field (DREIDING) were performed to study the interaction of 21 emerging contaminants with two all-silica zeolites, mordenite (MOR topology) and zeolite Y (FAU topology). The selection of adsorbents and adsorbates was based on a previous experimental investigation of organic contaminant removal using high-silica zeolites (Rossner et al., Water Res. 2009, 43, 3787–3796). An analysis of the lowest-energy configurations revealed a good correspondence between calculated interaction energies and experimentally measured removal efficiencies (strong interaction – high removal), despite a number of inherent simplifications. This indicates that such simulations could be used as a screening tool to identify promising zeolites for adsorption-based pollutant removal prior to experimental investigations. To illustrate the predictive capabilities of the method, additional calculations were performed for acetaminophen adsorption in 11 other zeolite frameworks, as neither mordenite nor zeolite Y remove this pharmaceutical efficiently. Furthermore, the lowest-energy configurations were analysed for selected adsorbent-adsorbate combinations in order to explain the observed differences in affinity.
Assessing the Performance of Density Functional Theory Methods on the Prediction of Low-Frequency Vibrational Spectra
Authors: Banks Peter , Song Zihui , Ruggiero Michael
Published: January 2020

The low-frequency (terahertz) dynamics of condensed phase materials provide valuable insight into numerous bulk phenomena. However, the assignment and interpretation of experimental results requires computational methods due to the complex mode-types that depend on weak intermolecular forces. Solid-state density functional theory has been used in this regard with great success, yet the selection of specific computational parameters, namely the chosen basis set and density functional, has a profound influence on the accuracy of predicted spectra. In this work, the role of these two parameters is investigated in a series of organic molecular crystals, in order to assess the ability of various methods to reproduce intermolecular forces, and subsequently experimental terahertz spectra. Specifically, naphthalene, oxalic acid, and thymine were chosen based on the varied intermolecular interactions present in each material. The results highlight that unconstrained geometry optimizations can be used as an initial proxy for the accuracy of interatomic forces, with errors in the calculated geometries indicative of subsequent errors in the calculated low-frequency vibrational spectra, providing a powerful metric for the validation of theoretical results. Finally, the origins of the observed shortcomings are analyzed, providing a basic framework for further studies on related materials.