bluuebunny/crossref_metadata_2025 huggingface dataset:
Some Attitudes of Professionals Towards the Agility of Their Educational Institution
Authors: Cencič Majda
Published: March 2023

Agility as a special way of thinking and acting was created by programmers and has spread to the pedagogical field. We are presenting the results of a survey among 184 professionals from various Slovenian educational institutions (EI) for the purpose of determining their attitudes towards the agility of EI. The results show that respondents agree the most with positive actions, positive emotions and care for children. They are most indecisive about simplifying issues and problems and highlighting mistakes. Based on multivariate hierarchic cluster analysis, we determined three clusters that, according to our research, define agile EI. We named them as follows: the individual and the operation of EI, positive mindset and adequate communication. All clusters relate to human resources and confirm the statement that the greatest challenge is to achieve change in people.
A rare constellation of horseshoe lung with lung malformation and hypoplastic left heart syndrome: a case report
Authors: Zaverza V. M. , Kozlova P. V. , Mashchenko I. A. , Borshevetskaya A. A. , Grekhov E. V. , Volkova Yu. V. , Trufanov G. E.
Published: March 2023

Introduction. The aim of the paper is demonstrating the possibilities of CT angiography in newborns with suspected combinations of a congenital heart defect and pulmonary malformations.

Materials and methods. The article presents a clinical case of a rare constellation of horseshoe lung with hypoplastic left heart syndrome, right lung hypoplasia and intralobar pulmonary sequestration of the right lung.

Results. Contrast-enhanced computed tomography is mandatory in visualization of rare complex congenital heart and bronchovascular anomaly.

Discussion. Horseshoe lung is a rare congenital anomaly of childhood in which the caudal and basal segments of the lungs are joined together anterior to the aorta and behind the left ventricle. This anomaly was described for the first time by Spenser in 1962. Horseshoe lung is often associated with unilateral lung hypoplasia, most commonly involving the right lung, and can occur in conjunction with scimitar syndrome, which includes hypoplasia of the right lung, abnormal right pulmonary venous return, and abnormal arterial supply to the right lung.

Conclusion. Presented case report demonstrates current postnatal examination possibilities (CT, angiography) in the diagnostics of a rare congenital heart and bronchovascular anomaly — hyperplastic left heart, intralobar pulmonary sequestration of the right lung, anomalous venous return, anomalous hepatic venous drainage. The incidence of this disorder is approximately 1–3 per 100 000 births.
Identification of the pathogenesis features of various phenotypes of multiple sclerosis based on the study of the morphological functional connectivity of subcortical gray matter structures
Authors: Trufanov A. G. , Polushin A. Y. , Gorbunova E. A. , Lukin M. V.
Published: March 2023

Objective. The aim of study: to investigate the functional changes in the thalamus, amygdala, and hippocampal region using functional MRI at rest and determine their clinical significance in various types of MS.

Materials and methods. 68 patients with a diagnosis of multiple sclerosis (MS) were examined: 40 patients with a relapsing-remitting MS (RRMS) in remission and 28 patients with secondary progressive MS without signs of activity and progression (SPMS). The control group consisted of 10 healthy people of the appropriate age and gender without neurological and somatic diseases. All patients and controls underwent MRI of the brain on a Siemens Tim Trio tomograph with a magnetic field induction of 3.0 TL, using contrast enhancement, T1 gradient echo protocols, REST-BOLD, and subsequent processing of the data obtained using CONN 19с software.

Results and conclusion. In the course of the study, various patterns of changes in functional connections were found: in patients with RRMS, there is a decrease in the intensity of connections of the thalamus with other brain structures and a decrease in their number. In patients with RRMS, a greater number and intensity of connections within the thalamus and other structures of the brain were detected compared to SPMS. In patients with RRMS, there is a significant decrease in the connectivity parameters of the hippocampal formation, which is expressed on the left, and in the case of the amygdala complex – on the right, this is manifested in a total decrease in the intensity of connections with other brain structures and a decrease in their number. Thus, the method of functional MRI at rest makes an additional contribution to the understanding of neurodegenerative processes in various phenotypes of multiple sclerosis.
Digital transformation in traditional society (on the example of the Kabardino-Balkarian Republic)
Authors: Atlaskirov Albert
Published: March 2023

Expanding as a result of information and technological progress, the processes of globalization are immersing the material world and the sphere of human relationships in the space of digital technologies. Leading experts note that the world community is on the verge of fundamental changes associated with technological breakthroughs in various fields of knowledge. The article discusses the regional features of digital transformation in the Kabardino-Balkarian Republic. If in developed countries and the most dynamically developing regions of Russia, the transition of society to a new era of digital technologies is a logical, natural, from the point of view of evolutionary development, phenomenon, then what is this process like in traditional societies? This question was central to the present work. The results of the study showed that people rightly point out both the positive and negative aspects of digital transformation. The problem of mass layoffs is relevant. People are afraid that robots and computer programs will force them out of the labor market. This problem is especially acute in such an economically depressed region as the Kabardino-Balkarian Republic. Also, people are concerned about the erosion of the cultural foundations of the titular peoples of the region, as a result of the processes of globalization, which are taking place with particular intensity in the digital world. At the same time, the respondents noted the presence of significant positive aspects of digital transformation. Welfare increases, the solution of many everyday problems is simplified, the quality of human life improves.
Prekariat jako nowe źródło nierówności w neoliberalizmie — kilka refleksji
Authors: Blicharz Jolanta
Published: March 2023

Prekariat jest globalnym zjawiskiem, które pojawiło się wraz z globalizacją gospodarki światowej i realizacją idei neoliberalizmu mającej na celu uczynienie rynku pracy jeszcze bardziej elastycznym. Neoliberalny program polityczny i gospodarczy sprawił, że wielu ludzi stało się ekonomicznie niepewnymi i zmarginalizowanymi, uwalniając jednocześnie mechanizmy ekonomiczne sprzyjające rozwojowi procesu „prekaryzacji społeczeństwa”.
„Niepodleganie karze z powodu cudzego czynu” z art. 16b kodeksu karnego skarbowego. Analiza krytyczna
Authors: Włodkowski Olaf
Published: March 2023

Celem opracowania jest analiza art. 16b kodeksu karnego skarbowego. Artykuł jest krytycznym zarysem tak zwanej klauzuli niepodlegania karze z powodu cudzego czynu. Przeprowadzono analizę z perspektywy ratio legis jej wprowadzenia, istoty tej instytucji oraz przesłanek ją aktualizujących, podstawowych zasad odpowiedzialności karnej za przestępstwo skarbowe, a także zasad odpowiedzialności za wykroczenie skarbowe, jak również funkcji, istoty oraz przesłanek stosowania instytucji zaniechania ukarania sprawcy z rozdziału 2 kodeksu karnego skarbowego uzasadnia uchylenie art. 16b.
The problem of tensions between the constitutional principle of freedom of speech and freedom of the press and the limits of access to information and publishing in Poland
Authors: Żukowski Łukasz
Published: March 2023

Although freedom of speech and freedom of the press are guaranteed by the norms of the Constitution and confirmed by international obligations, in practice the implementation of these norms encounters numerous difficulties. Practicing the profession of a journalist depends on the conditions of access to information, including public information. Access to public information can be classified as one of public subjective rights, so it is the legislator’s duty to shape the legal infrastructure in such a way as to create eff ective mechanisms that guarantee the transparency of the activities of public authorities, and thus the openness of public life. However, the regulations specifying the work of journalists are multi-level in nature and necessarily provide for numerous restrictions, causing tensions between the freedom of speech and other values guaranteed by the Constitution.
Interes prawny w uzyskaniu zaświadczenia w świetle regulacji k.p.a.
Authors: Strzępek Łukasz
Published: March 2023

Uwarunkowanie uzyskania zaświadczenia od legitymowania się interesem prawnym nastręcza istotnych problemów teoretycznych i praktycznych. Rozbieżności poglądów prezentowane w orzecznictwie sądów administracyjnych uzasadniają bliższe przyjrzenie się tej problematyce. Szczególnie istotną kwestią wydaje się ustalenie, czy interes prawny w uzyskaniu zaświadczenia jest tożsamy z interesem prawnym warunkującym udział w postępowaniu administracyjnym jako strona. Odpowiedź nie jest w tym przypadku jednoznaczna ze względu na odmienny charakter instytucji zaświadczenia, a konkluzje zawarte w niniejszym opracowaniu mogą być przyczynkiem do dalszej dyskusji w tym temacie.
The role and place of phonetics in the process of learning Chinese language
Authors: Leonova Daria Y. , Tikhonova Evgeniya V.
Published: March 2023

In the process of learning Chinese, students often make typical mistakes that greatly affect communication and the learning process as a whole. With the analysis, it was found that at the initial stage, students have the most difficulties when mastering phonetics. This is primarily due to the difference in the phonetic systems of Chinese and Russian languages. Mistakes in the pronunciation of sounds, incorrect pronunciation of tones, pauses in a word or phrase distort the meaning of the utterance, interfere with the correct perception of information and are very difficult to correct if you do not pay attention to them in time. To avoid difficulties in communicating in Chinese, it is necessary to pay great attention to teaching phonetics, especially at the initial stage of training. A brief overview of the methodology of research in the field of phonetics is given, a number of errors identified in students and how these errors affect the communication process are given, thus confirming the important role of phonetics in teaching Chinese.
Pre-revolutionary kindergartens and nurseries: from the history of the formation of preschool educational institutions in the Tambov Region
Authors: Matorina Irina V.
Published: March 2023

In the context of reforming the domestic education system, including preschool, as its first stage, the problem of the formation and development of preschool educational institutions is becoming urgent again. The domestic historical and pedagogical experience of the functioning of pre-revolutionary children’s institutions can become an important reference point in the modernization of the system of preschool educational organizations at the present stage. The process of formation of preschool educational institutions in the Tambov region is considered; Main types of pre-revolutionary preschool institutions that have become widespread in the Tambov region are identified: nurseries-orphanages for peasant children, city nurseries and orphanages, private kindergartens and playgrounds. The emphasis is placed on the cultural and educational significance of the activities of children’s institutions of the public charity system, which made it possible to consider them as a prototype of public kindergartens. The reasons for the slow development of the network of preschool institutions in Russia and in the Tambov governorate in particular are revealed. The role and degree of participation in the organization of preschool educational institutions of state, as well as private and public initiatives are clarified. Mainly published and archival sources have been analyzed, which allowed us to identify the regional features of the formation of preschool educational institutions in the Tambov region at the governorate and county levels in the specified chronological period through the prism of the demand for estate-social, professional and ethno-confessional groups of the population and conclude that the formation of preschool educational institutions in the Tambov region began at the end of the 19th century – beginning of the 20th century.
Theoretical aspects of the problem of educational motivation development among students of higher education in foreign studies
Authors: Kaitov Aleksandr P.
Published: March 2023

The relevance of the research topic is due to the importance of the problem of educational motivation development among students of higher education to improve the quality and efficiency of higher education. Analysis and generalization of foreign experience makes it possible to identify and include in the domestic educational practice of developing the educational motivation of students of higher education the most successful pedagogical solutions and developments that have empirically proven their effectiveness. Purpose: based on the analysis of foreign sources on the problem of educational motivation development of students of higher education, to determine and characterize the current theories applied to the study of educational motivation of students, the factors that influence its development, methods and teaching strategies. We prove that the main condition for the positive development of students’ motivation for learning and research activities is the creation by university teachers of a motivating educational environment, including: encouraging students to focus on the goals of mastery, developing competence, granting autonomy, creating zones of proximal development, etc. It is concluded that it is expedient to include foreign experience in teaching students positive motivational strategies focused on the development of motivational competence in the domestic educational practice of higher education.
Target guidelines for the formation of project activity of students in the conditions of specialized training
Authors: Mosina Oksana A. , Danilyants Eduard I.
Published: March 2023

In the presented study, the need for the development of project activity of students in a modern professionally oriented high school is determined, and its targets are identified, which make it possible to track the effectiveness of pedagogical activity and personal development of the student. Among the scientific approaches, the practice-oriented approach of D. Dewey and the concept of the “open” school of T.S. Shatsky, which have found application and development in modern scientific psychological and pedagogical discourse, are predominant. The criteria for the formation of project activity: motivational, cognitive, rational, personal, promising allowed us to determine a list of indicators that can be monitored through diagnostic tools, which allows us to develop the conclusions obtained experimentally. The theoretical conclusions made were confirmed by the calculation of the expediency index, as well as by an expert survey of teachers of educational organizations in the number of twenty-eight people. In general, the conducted research demonstrates the need to develop the project activity of students in the educational process, as well as to design the educational process in such a way that the personal development of students becomes more ambitious, professionally oriented and aimed at the personal development of students. The presented results can be applied in the process of research and educational work in higher educational institutions.
Mobil Bankacılık Uygulamalarının Benimsemesini Etkileyen Faktörler: Genç Tüketiciler Üzerinde Bir Araştırma
Authors: ALKAÇ ÖZDEMİR Gülsen
Published: March 2023

Hızlı teknolojik gelişmeler birçok işletmenin gelişen teknolojiyi takip etmesini ve hızlıca adapte olmasını gerektirmektedir. Son yıllarda geliştirilen mobil uygulamalar tüketici davranışlarında önemli bir yere sahiptir. Bankalar, hizmet sunumlarında mobil uygulamaları diğer birçok sektöre kıyasla erken kullanmaya başlamıştır. Ancak bu uygulamaların başarılı olmasında tüketici kabulü oldukça önemlidir. Bu çalışmanın amacı, genç tüketicilerin mobil bankacılık uygulamalarının kabulünü etkileyen faktörlerin tüketicilerin mobil bankacılık uygulamalarını kullanmaya yönelik davranışsal niyeti üzerindeki etkisini ortaya koymaktır. Araştırma verileri çevrimiçi anket yöntemiyle toplanmıştır. Elde edilen veriler Smart PLS yapısal eşitlik modellemesiyle analiz edilmiştir. Analiz sonucunda algılanan yarar ve algılanan uyum faktörlerinin genç tüketicilerin mobil bankacılık uygulamalarını kullanmaya yönelik davranışsal niyeti üzerinde pozitif etkiye sahip olduğu bulunmuştur. Araştırma modelindeki algılanan kullanım kolaylığı, sosyal etki, kolaylaştırıcı koşullar, göreceli avantaj ve algılanan risk boyutlarının ise genç tüketicilerin mobil bankacılık uygulamalarını kullanmaya yönelik davranışsal niyeti üzerinde anlamlı bir etkisi bulunmamıştır. Genç tüketicilerin mobil bankacılık uygulamalarını kullanmaya yönelik davranışsal niyetin, kullanma davranışına etkisi de oldukça yüksek bulunmuştur. Bulgular, mobil banka uygulamalarının geliştirilmesinden ve pazarlama stratejilerinin belirlenmesinden sorumlu banka yöneticilerine yardımcı olabilecektir.
Perú: Consolidación Fiscal 1980-2020 y Retos a la Fecha —Una Aproximación
Authors: Pastor Gonzalo
Published: March 2023

Esta nota narra la consolidación fiscal ocurrida en los últimos 40 años, las evoluciones en los conceptos de déficit fiscal monitoreados en el análisis fiscal, y el impacto de la condicionalidad del Fondo Monetario Internacional (FMI) inmersa en los sucesivos programas financieros subscritos entre Perú y el FMI sobre la evolución de los principales agregados fiscales. La nota también elabora en los logros y retos de gestión pública a la fecha.
Exploring the Interconnectedness of Supply Chain Management Theories: A Literature Review
Authors: Uddin Muhammed Sameer , Habib Md. Mamun , Mohamed Omaima Eltahir Babikir
Published: March 2023

This literature review presents a systematic review of popular supply chain management (SCM) theories, focusing on their definitions, early development, and contributions to the field. Seven fundamental theories are analyzed in detail: Resource-Based View, Agency Theory, Transaction Cost Theory, Stakeholder Theory, Balanced Scorecard Theory, Knowledge-Based View Theory, and Strategic Choice Theory. The study traces the origins and evolution of these theories, highlighting their unique foundations and the contexts in which they emerged. The review also discusses the fundamental principles and underlying assumptions of each theory, emphasizing their relevance to SCM and the implications for its practice. The review shows how these theories have helped us understand and improve SCM and how they can improve supply chain performance, promote sustainability, and drive innovation. This thorough analysis is a helpful tool for researchers, practitioners, and policymakers who want to learn more about the different theories that continue to shape and inform the field of supply chain management.
A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-Heparanase and Anti-Migratory Activities
Authors: Manseur Chanez , Groult Hugo , Porta Manon , Bodet Pierre-Edouard , Bridiau Nicolas , Mersni-Achour Rachida , Petit Raphaëlle , Ali-Moussa Samir , Musnier Benjamin , Le Cerf Didier , Varacavoudin Tony , Haddad Oualid , Sutton Angela , Piot Jean-Marie , Maugard Thierry , Fruitier-Arnaudin Ingrid
Published: March 2023

Oligosaccharides derived from λ-carrageenan (λ-COs) are gaining interest in the cancer field. They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications. However, one of the specific features of commercial λ-carrageenan (λ-CARs) is that they are in fact heterogeneous mixtures of different CARs families, and are named according to the thickening purpose of the product which does not reflect the real com-position. Consequently, this can limit their use in a clinical grade. To address this issue, six commercial λ-CARs were compared for which differences in their physiochemical properties were shown. Then, a H2O2-assissed radical depolymerization was applied to each commercial source and the number and weight averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined. By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in term of molar masses and DS, that ranged within previously reported values suitable for anti-tumor proper-ties. However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features such as differences in the initial mixture composition. Further structural MS and NMR analysis revealed indeed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, but also showed that H2O2-based hydrolysis induced sugar degradation. Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.
Comparative Metabolomics Profiling Reveals Key Metabolites and Associated Pathways Regulating Tuber Dormancy in White Yam (Dioscorea rotundata)
Authors: Nwogha Jeremiah S. , Wosene Abtew G. , Raveendran Muthurajan , Obidiegwu Jude E. , Chilaka Cynthia A. , Oselebe Happiness O. , Kambale Rohit , R. Veera Ranjani
Published: March 2023

;Yams are economic and medicinal crops with a long growth cycle, spanning between 9-11 months due to the prolonged tuber dormancy. Tuber dormancy has constituted a major constraint in yam production and genetic improvement. In this study, we performed non-targeted comparative metabolomic profiling of tubers of two white yam genotypes, (Obiaoturugo and TDr1100873), to identify metabolites and associated pathways that regulate yam tuber dormancy using gas chromatography-mass spectrometry (GC-MS). Yam tubers were sampled between 42 days after physiological maturity (DAPM) till tuber sprouting. The sampling points include 42-DAPM, 56-DAPM, 87DAPM, 101-DAPM, 115-DAPM, and 143-DAPM. A total of 949 metabolites were annotated, 559 in TDr1100873 and 390 in Obiaoturugo. 39 differentially accumulated metabolites (DAMs) were identified across the studied tuber dormancy stages in the two genotypes. 27 DAMs were conserved between the two genotypes, whereas, 5 DAMs were unique in the tubers of TDr1100873 and 7 DAMs were in the tubers of Obiaoturugo. The differentially accumulated metabolites (DAMs) spread across 14 major functional chemical groups. Amines and biogenic polyamines, amino acids and derivatives, Alcohols, flavonoids, alkaloids, phenols, esters, coumarins and phytohormone positively regulated yam tuber dormancy induction and maintenance, whereas, fatty acids, lipids, nucleotides, carboxylic acids, sugars, terpenoids, benzoquinones, and benzene derivatives positively regulated dormancy breaking and sprouting in tubers of both yam genotypes. Metabolite set enrichment analysis (MSEA) revealed that 12 metabolisms were significantly enriched during yam tuber dormancy stages. Metabolic pathway topology analysis further revealed that six metabolic pathways (linoleic acid metabolic pathway, phenylalanine metabolic pathway, galactose metabolic pathway, starch and sucrose metabolic pathway, alanine-aspartate-glutamine metabolic pathways and purine metabolic pathway) exerted significant impact on yam tuber dormancy regulation. This result provides vital insights into molecular mechanisms regulating yam tuber dormancy.
Combinatorial Effect of Multiple Variables on Carotenoids and Lipids Up-Regulation in Monoraphidium sp. for Pharmacological and Nutraceutical Applications
Authors: Yadav Kushi , Kumar Shashi , Nikalje Ganesh Chandrakant , Rai Monika Prakash
Published: March 2023

Carotenoids are essential pigments that play a vital role in the photosynthetic process of algae and are important for human health and nutrition. Despite their potential value, algal carotenoids are being neglected by biofuel industries. Recent research is aimed at producing microalgal lipids and carotenoids simultaneously under abiotic stresses. In this study, the effect of different abiotic stress factors such as Nitrogen (N), Potassium (K), Phosphorous (P), Sulphur (S), light intensity, and photoperiod on biomass, lipid, and carotenoids synthesis in Monoraphidium sp. (MP) were explored utilizing a statistical method. In addition, 2, 7-dichlorofluorescein diacetate (DCF-DA) mediated spectrofluorimetry was employed to detect the ele-vation in ROS level. The results revealed that variations in nutrients and light con-ditions are the key factors in the up-regulation of biomolecules lipids and carote-noids in the algae. The carotenoids profiling was done by Ultra Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectroscopy (UPLC-Q-ToF-MS). Among consisting carotenoids violaxanthin, astaxanthin, and beta-carotene were enhanced by 1.3 folds, 1.19 folds, 1.08 folds, while lutein was declined by 1.32 folds under stressed condition compared to control. The identified carotenoids are rec-ognized for their importance in the pharmaceutical and nutraceutical industries, highlighting the significant role of MP in these sectors.
Improved Prediction of Antisense Oligonucleotide Efficacy for Exon Skipping Using Ensemble Learning and Feature Selection
Authors: Zhu Alex , Chiba Shuntaro , Shimizu Yuki , Kunitake Katsuhiko , Okuno Yasushi , Aoki Yoshitsugu , Yokota Toshifumi
Published: March 2023

Antisense oligonucleotide (ASO)-mediated exon skipping has become a valuable tool for investigating gene function and developing gene therapy. Machine learning-based computational methods such as eSkip-Finder have been developed to predict the efficacy of ASOs via exon skipping. However, these methods are computationally demanding, and the accuracy of predictions remains suboptimal. In this study, we propose a new approach to reduce computational burden and improve prediction performance by using feature selection within machine learning algorithms and ensemble learning techniques. We evaluated our approach using a dataset of experimentally validated exon skipping events, dividing it into training and testing sets. Our results demonstrate that using a 3-way voting approach with random forest, gradient boosting, and XGBoost can significantly reduce computation time to under ten seconds while improving prediction performance, as measured by R2 for both 2’-O-methyl nucleotides (2OMe) and phosphorodiamidate morpholino oligomers (PMOs). Additionally, the feature importance ranking derived from our approach is in good agreement with previously published results. Our findings suggest that our approach has the potential to enhance the accuracy and efficiency of predicting ASO efficacy via exon skipping. It could also facilitate the development of novel therapeutic strategies. This study could contribute to the ongoing efforts to improve ASO design and optimize gene therapy approaches.
Cranial Bone Changes Induced by Mild Head Impacts: A Neglected Player in Concussion Outcomes?
Authors: Semple Bridgette , Panagiotopoulou Olga
Published: March 2023

Mild impacts to the head, particularly when repetitive in nature, are increasingly recognized to have a range of significant negative implications for brain health. Much of the ongoing research in the field is focused on the neurological consequences of these injuries, and the relationship between head impacts and long-term neurodegenerative conditions such as chronic traumatic encephalopathy and Alzheimer’s disease. However, our understanding of the complex relationship between applied mechanical force at impact, brain pathophysiology, and neurological function, remains incomplete. Past research has shown that mild head impacts, even below the threshold that results in cranial fracture, induce changes in cranial bone structure and morphology. These structural and physiological changes likely have implications for the transmission of mechanical force into the underlying brain parenchyma. Here, we review this evidence in the context of the current understanding of bone mechanosensitivity and the consequences of traumatic brain injuries or concussions. We postulate that heterogeneity of the calvarium including differing bone thickness due to prior impacts, age, or individual variability, may be a modulator of outcomes following subsequent head impacts. We advocate for greater consideration of cranial responses to head injury in both experimental and computer modeling of impact biomechanics, and raise the hypothesis that calvarial bone thickness represents a novel biomarker of brain injury vulnerability after head trauma.
CVM: Crossbar-Based Circuit Verification Through Modeling
Authors: Datta Rajesh
Published: March 2023

The implementation of Boolean functions using Nano crossbar- based switching lattices has been suggested as a substitute for conventional CMOS-based approaches in digital circuits [4]. This alternative may satisfy the needs of future electronic designs, con- sidering the expected end of Moore’s law. This study introduces CVM, a Crossbar-based circuit Verification through Modeling tech- nique
SIFAT FISIK DAN MEKANIK MORTAR DENGAN CAMPURAN LIMBAH ABU BATU BATUAN VULKANIK SEBAGAI PENGGANTI PASIR
Authors: Kusumaningrum Evy , Sumarsono Sumarsono , Faizah Restu , Chotimah Nurul
Published: March 2023

Kasus pencemaran lingkungan sebagian besar diakibatkan oleh kurang tepatnya penanganan limbah di beberapa daerah. Limbah merupakan hasil sisa dari suatu kegiatan produksi. Daerah Ponjong, Gunung Kidul, Yogyakarta sebagian besar masyarakat menekuni pekerjaan  penggergajian batu alam.  Limbah yang dihasilkan dari kegiatan penggergajian batu alam adalah abu batu dan pecahan batu. Limbah abu batu dan pecahan batu tersebut belum dimanfaatkan secara maksimal. Limbah yang menumpuk mengakibatkan tanah menjadi keras dan kesuburannya berkurang. Berdasarkan permasalahan tersebut maka pada penelitian ini mengusulkan tentang analisis sifat fisik dan mekanik beton dengan campuran abu batu sebagai pengganti agregat halus sebagai pengganti pasir pasir. Hasil penelitian ini diharapkan akan mengetahui sifat fisik dan mekanik beton dengan campuran abu batu sebagai pengganti pasir. Komposisi abu batu sebagai pengganti pasir  yaitu 0%, 10%, 20%, 30%, 40% dan 50% dari berat pasir. Dari komposisi tersebut benda uji akan di uji densitas (density), kuat tekan (compression strength) pada umur beton 28 hari. Pengujian benda uji menggunakan Universal Testing Machine. Nilai densitas yang diperoleh pada benda uji mengalami penurunan nilai densitas. Semakin banyak komposisi abi batu sebagai pengganti pasir nilai densitasnya semakin kecil. Begitu juga dengan hasil uji kuat tekan mortar. Kuat tekan mortar dengan komposisi abu batu semakin banyak maka kuat tekan beton semakin menurun.  
Consequencialismo, garantismo e a Lei de Introdução às Normas do Direito Brasileiro: uma interpretação conciliatória
Authors: Santiago Nestor Eduardo , Sousa Francisco Arlem
Published: March 2023

Com o pós-positivismo abrem-se as veredas para a criação e ampliação do direito por parte dos juízes. Na atividade criativa judicial, na qual pode se vislumbrar o o ativismo, é pertinente o debate entre a doutrina garantista, cujo maior expoente é Luigi Ferrajoli, e a doutrina consequencialista, que tem em Richard Posner seu referencial máximo. O garantismo se baseia na rígida subordinação à lei, impondo limites e vínculos a todos os poderes, visando a máxima efetividade dos direitos fundamentais. O consequencialismo enfatiza que a decisão judicial deve primar pela produção dos melhores efeitos para a sociedade, ainda que, eventualmente, a lei seja inobservada. Em que pesem as divergências, garantistas e consequencialistas dão as mãos para combater o panprincipiologismo, que representa a invenção e o uso abusivo dos princípios pelo Judiciário para justificar qualquer decisão solipsista. O art. 20 da Lei de Introdução às Normas do Direito Brasileiro abre às portas para o consequencialismo no ordenamento jurídico nacional, visando impor limites ao ativismo judicial, objetivo almejado também pelos garantistas.
The Role of The Word of Mouth Mediate The Effect of The Marketing Mix on The Decision of Student Parents to Choose Muhammadiyah School
Authors: Alwifaqi Jindan , Ambarwati Rita
Published: March 2023

This research aims to determine the role of word of mouth in mediating the effect of the marketing mix on the decision of parents of students to choose SMP Muhammadiyah 9 Tanggulangin boarding school, Sidoarjo. This research uses sample data collection through questionnaires. With the number of respondents 125 guardians of SMP Muhammadiyah 9 boarding school Tanggulangin Sidoarjo. For data analysis in this study using statistical techniques Partial Least Square (PLS). The results of this study indicate 2 direct effects are significant, 1 direct effect is not significant. Namely Marketing Mix (X) on parents 'decision to choose school (Y), Marketing Mix (X) on Word of Mouth (Z) and the direct effect that is not significant, namely Word of Mouth (Z) on parents' decision to choose school (Y) . And this study shows that there is an indirect effect that is not significant, namely the Marketing mix on the decision of parents to choose school (Y) through the Word of Mouth (Z).
The Effect of Problem Based Learning Based on Hybrid Learning on Problem Solving in Mathematics Subjects at Islamic School
Authors: Arifia Gadis , Nurdyansyah
Published: March 2023

The purpose of this study is to analyze the effect and how much influence PBL (Problem Based Learning) based on hybrid learning has on solving mathematical problems at MI Al-Islam Plumpang.

        The research method used is quantitative research. Quantitative research is a research method that tests certain theories by examining the relationship between variables which are usually measured by research instruments so that they can produce data in the form of numbers (Creswell, 2012:5). In addition, data collection techniques using questionnaires (questionnaires), tests, and documentation. While the data analysis used is the normality test, validity test, reliability test, and T test (partial).

                Based on the data obtained from the results of the validation test, reliability test, and normality test, and the t-test, it can be concluded that the significance value of the experimental group is 0.531. So that 0.531 > 0.05, the problem-based learning model based on hybrid learning on problem solving in mathematics has a significant effect on students' understanding of mathematics in class 4 MI AL-Islam.
The Use of Google Classroom in the Maharah Qiroah Learning in the Time of Covid 19 Eight Grades at Islamic High School
Authors: Sholikhah Mar'atus , Hikmah Khizanatul
Published: March 2023

Researches are doing the google classroom application study of the maharah qiroah at the covi 19 of 8th grades at the SMPIT Darul Fikri Sidoarjo. The covid 19 made department decide that the study has been online since March 2020 to break the chain of infection. One is the application and one of the best platforms on e-learning is google classroom. The type of research used by researches is qualitative research. Data collection techniques used by researches are observation, interview, and documentation. While in data analysis techniquesuse interactive analysis techniques, researchers use three part interactive abalysis tehcniques of data reduction, data presentation, and conculasions. The result of this study :1)Maharah Qiroah learning using google classroom during covid 19 can help student were encourge to studying maharah qiroah, 2)Some contributing in the application of google classroom in the maharah qiroah learing during covid 19 are given more interesting materials and the flexibility of time to do the job, 3)Some of the inhibiting factors are the lack of steady internet connections as well as the inadequate student media.
Aplicación del flushing en ovejas pre y post servicio
Authors:   , Zegarra Traverso Rodrigo
Published: March 2023

La producción ovina está basada en el sistema de pastoreo, el cual permite reducir los costos de la alimentación; sin embargo, pocas veces se cumplen con los requerimientos nutricionales de los animales, ya sea por la poca cantidad o por la poca calidad de los pastos. La inclusión de estrategias nutricionales resulta ser clave para mejorar la producción de las ovejas. El presente trabajo busca dar alcances de la estrategia nutricional conocida como flushing en las ovejas pre y post servicio, que es la práctica nutricional de suplementación a las hembras brindada de 15 a 21 días antes de la temporada de empadre y unas pocas semanas después; con el objetivo de mejorar las tasas de ovulación y disminuir las pérdidas embrionarias. En la presente revisión se dará a conocer los nutrientes involucrados, los mecanismos de acción y el tiempo de aplicación del flushing, además de revisar factores que influyen en el flushing y los posibles insumos que se les pueden suministar a las ovejas al utilizar este manejo nutricional con la finalidad de brindar información útil para los productores que emplean esta estrategia.
Implementación de un datamart para la mejora de toma de decisiones en el área comercial de empresa de eventos
Authors:   , Cari Sarmiento Roy Angel
Published: March 2023

Tomar decisiones rápidas y correctas en el negocio es la clave del éxito de la empresa. Sin embargo, algunas empresas ahora tienen limitaciones para ver la información, lo que hace que las decisiones tácticas comerciales de la empresa sean muy rápidas. Según Shone y Parry (2019) en su libro “Successful Event Management: 5th Edition” define evento como un fenómeno provocado por una ocasión no convencional, ya sea con la finalidad de descanso, instructivo o propio, diferentemente de otras actividades recurrentes, pero manteniendo su objetivo de causar expectativas ya sean buenas o malas del grupo de participantes involucrados. El propósito de esta investigación es utilizar DATAMART en el ámbito comercial, en un intento por encontrar un nuevo mercado con gran potencial, que aún no ha sido considerado en la organización.
Plan de negocio de venta de productos orgánicos a través de tienda rodante en Santiago de Surco
Authors:   , Seminario Luna Kevin Gilberto , Chilcho Samame Mirella , Palomino Florencio Carmen Elena , Buiza Avalos Luz Isabel , Raffo Castro Smith
Published: March 2023

La presente investigación busca realizar la implementación de la empresa Sallqa Pacha. La empresa tendrá su oficina en el distrito de Surquillo bajo el régimen MYPE, abordaremos la venta de alimentos orgánicos y naturales. Iniciaremos las actividades el presente año con la venta de productos orgánicos y naturales orientado al público en general de los segmentos B y C del distrito de Santiago de Surco. El modelo utilizado será el de un market truck, el cual se ubicará en distintos puntos del distrito como parques, plazas y espacios abiertos bajo el contexto de la pandemia y la búsqueda de evitar cada vez menos contagios. En el trabajo a continuación, mostraremos las etapas que consideramos nos van a generar el valor necesario para hacer rentable el plan de negocios y sostenible. Se mostrará la misión, visión y valores de la empresa y cómo será la organización para iniciar y desarrollar nuestras actividades, se evaluará el entorno y como influencian en nuestro proyecto, finalmente realizaremos el análisis de marketing, social y político con la finalidad de identificar el procedimiento para inicial las funciones y hacerlas sostenibles y rentables en el tiempo.
Beneficios de una dieta natural para canes
Authors:   , Marcani Mendoza Gianella Karina
Published: March 2023

El presente trabajo de investigación es una revisión bibliográfica de los beneficios de una dieta natural para canes. Dentro de la revisión se abordan aspectos relacionados al aparato digestivo en perros, fisiología digestiva y características de la microbiota intestinal, hábitos alimenticios en canes, requerimientos nutricionales y los tipos de dietas más usadas en canes; haciendo énfasis en la importancia que tiene una dieta natural cuya validez es sustentada en diversos estudios. La información presentada busca aportar nuevos conocimientos y alcances tanto a propietarios como a médicos veterinarios sobre la dieta natural como alternativa de alimentación para los canes, debido a que este tipo de dieta ha recibido creciente atención en los últimos años ya que se han visto reflejados algunos aportes en la salud del animal y porque se ha generado mayor interés en querer brindar un alimento bueno que cumpla con los requerimientos nutricionales para la mascota.
Intervención comunitaria en adultos mayores de la Asociación Los Ángeles de Jesús en Lurín
Authors:   , Reyes López Daniela Carolina , Sicha Castillo Gisell Alessandra , Villegas Castro Lizeth Monica
Published: March 2023

La presente investigación se dio mediante una intervención comunitaria, donde la finalidad fue identificar aquellas necesidades sentidas y brindar acompañamiento a los adultos mayores. Esta corresponde a un tipo de estudio aplicado con diseño de investigación acción, en una comunidad de 12 adultos mayores de ambos géneros, miembros de la Asociación Adultos Mayores Ángeles de Jesús ubicado en el distrito de Lurín-Lima. Se utilizaron técnicas como la observación, la encuesta y el taller participativo, así mismos instrumentos de recolección, entre ellos: “ficha de observación”, “ficha sociodemográfica” y “el árbol de problemas”. Con relación a los resultados, se obtuvo que la Asociación Ángeles de Jesús cumple con los criterios para ser considerado una comunidad. Además, se identificó que la necesidad sentida que ellos manifestaron fue la depresión. En cuanto a la participación comunitaria se destacó la participación co-planificada y se observó que favorecen al empoderamiento individual, ya que se considera los aportes de cada participante y esta es valorada. Finalmente, la comunidad se caracteriza por un estilo de liderazgo democrático.
Proliferación de microalgas en plantas de tratamiento de aguas residuales
Authors:   , Arbaiza Gonzales Taciana María
Published: March 2023

El tratamiento de aguas residuales es en la actualidad un mecanismo necesario para satisfacer la necesidad en situaciones donde no hay la posibilidad de contar con una fuente continua de agua. Múltiples tecnologías son empleadas para este fin, cuyo grado de complejidad depende del uso para el cual se va a disponer el agua tratada, el marco normativo que indique los parámetros de calidad que debe alcanzar y la inversión para contar con la infraestructura necesaria. Cuando la concentración de fósforo y nitrógeno es elevada en el agua a ser tratada y existen las condiciones favorables, se da el escenario perfecto para la proliferación de microalgas, las cuales al no ser controladas presentan un obstáculo en el adecuado tratamiento de aguas residuales. En la presente investigación se enmarca el escenario del tratamiento de aguas residuales en el Perú, las condiciones que favorecen la proliferación de microalgas en el caso de un reconocido club en Lima, así como diversas opciones para afrontar esta problemática.
Impacto del uso de agroquímicos en el servicio ecosistémico de polinización que brindan las abejas
Authors:   , Villarreal Contreras Joaquín David
Published: March 2023

Los pesticidas son sustancias utilizadas para contrarrestar organismos perjudiciales para el cultivo de plantas y/o animales de producción. Los pesticidas más utilizados por su gran efectividad son los organofosforados entre los cuales se encuentran el fenthion y el clorpirifos; sin embargo, el uso de estos pesticidas también afecta de manera directa a organismos benéficos, para el ambiente y para la población, como las poblaciones de abejas. El objetivo de esta revisión es dar a conocer cómo la exposición de estos insectos benéficos a los pesticidas afecta de manera considerable su sistema nervioso y su sentido de orientación, principalmente, lo cual impide que el servicio ecosistémico de polinización que estas brindan se realice de manera habitual. Como resultado, la pérdida del servicio ecosistémico de polinización que brindan las abejas genera impactos ambientales negativos debido a que gran parte de plantas silvestres necesitan de su polinización para existir; así como también, afecta el bienestar del hombre y la biodiversidad que lo rodea. Además, la pérdida de este servicio ecosistémico, que estos organismos proveen, genera impactos económicos negativos debido a que es de vital importancia para la producción agrícola global; por lo que podría alcanzar pérdidas monetarias valoradas en estimaciones billonarias a nivel mundial.
Plan de importación y comercialización de textiles para la limpieza del hogar en la ciudad de Lima, año 2020
Authors:   , Crisóstomo Cubas Emerson Boris , Jesús Sucasaire Alexandra Dalendy
Published: March 2023

El presente trabajo tiene como objetivo general demostrar la factibilidad y rentabilidad de la creación de la empresa HADA MADRINA S.A.C, por la cual la cual se dedicará a la importación y comercialización de textiles para la limpieza del hogar de procedencia China. El año 2020 trajo consigo una aterradora sorpresa para todos, esto es la aparición del COVID-19, trayendo un porcentaje alto a nivel mundial a la pobreza tanto a países altos y países bajos, en el caso específico del Perú, según el INEI, casi siete millones de personas se quedaron sin empleo desde que se decretó el Estado de emergencia. Casi todas las industrias se paralizaron a raíz de la pandemia, desde el sector de transporte hasta el sector hotelero; por otro lado, la demanda por los artículos de limpieza se disparó desde el inicio del confinamiento a nivel nacional, en este escenario nos parece ideal para emprender nuestra idea de negocio. La metodología utilizada para determinar la demanda potencial de los productos a importar se llevó a cabo a través de una encuesta dirigida a nuestro mercado objetivo, esta nos permitió confirmar la aceptación de nuestra idea de negocio.