bluuebunny/crossref_metadata_2025 huggingface dataset:
Fray Antonio Alcalde. Un mural en el Hospital Civil
Authors:   Universidad de Guadalajara, Padilla López Horacio
Published: February 2025

En el viejo Hospital Civil de Guadalajara se encuentra un mural de aproximadamente 8.5 por 3.5 metros, obra del artista jalisciense Gustavo Peralta, el cual se titula “Vida y obra de Fray Antonio Alcalde”. Este mural es un documento histórico que nos ubica a lo largo del siglo XVIII, sitúa la esencia de un tiempo, expresa una serie de acontecimientos precisos y ofrece una versión histórica de primera mano. El pintor se vuelve un cronista tanto de la sociedad novohispana de mediados de los años 1700, donde la razón iluminaba a la humanidad. Este libro presenta una descripción de todo el contexto del mural en honor a fray Antonio Alcalde, un hombre que promovió la difusión del conocimiento a través de las universidades, apelando por la salud, la espiritualidad y el amor al prójimo.
Khảo sát đặc điểm sử dụng kháng sinh điều trị viêm phổi cộng đồng tại Bệnh viện Nhi Đồng 1
Authors: Trương Hữu Phương , Ngô Ngọc Quang Minh , Nguyễn Thị Bích Nga , Nguyễn Hương Thảo
Published: February 2025

Đặt vấn đề: Viêm phổi cộng đồng (VPCĐ) gây ra gánh nặng bệnh tật và tử vong ở trẻ em trên toàn cầu, cũng như tại Việt Nam.

Mục tiêu: Khảo sát đặc điểm sử dụng kháng sinh và các yếu tố liên quan đến thời gian nằm viện ở bệnh nhi (BN) VPCĐ.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang mô tả trên hồ sơ bệnh án (HSBA) của BN, từ 2-60 tháng tuổi, VPCĐ điều trị nội trú tại Bệnh viện Nhi Đồng 1 năm 2022. Việc sử dụng kháng sinh tuân thủ hướng dẫn được đánh giá theo các khuyến cáo điều trị hiện hành.

Kết quả: Nghiên cứu thu thập 280 HSBA, với 36,8% BN từ 12-<24 tháng tuổi, 50,7% viêm phổi nặng. Kháng sinh ceftriaxon được dùng nhiều nhất (70,7%). Tỷ lệ tuân thủ hướng dẫn của kháng sinh kinh nghiệm và cả quá trình điều trị lần lượt là 67,1% và 60,4%. Toàn bộ BN được điều trị thành công, số ngày nằm viện trung vị là 7 (6;8). Sử dụng kháng sinh tuân thủ hướng dẫn (OR=0,338; 95% CI 0,201-0,567) và điều trị tại khoa Hô hấp (OR=0,432; 95% CI 0,257-0,729) liên quan đến giảm thời gian nằm viện.

Kết luận: Việc sử dụng kháng sinh tuân thủ hướng dẫn trong điều trị VPCĐ còn hạn chế. Cần có can thiệp phù hợp để cải thiện tính hợp lý trong sử dụng kháng sinh.

Từ khoá: viêm phổi cộng đồng; trẻ em; kháng sinh
Phát triển mô hình pharmacophore cho chất chủ vận trên PPARs trong nghiên cứu thuốc điều trị rối loạn lipid huyết
Authors: Nguyễn Thụy Việt Phương , Nguyễn Đức Xuân Thụy Sĩ , Nguyễn Hoàng Gia Bảo
Published: February 2025

Đặt vấn đề: Chất chủ vận đa thụ thể trên PPARs hay chủ vận đơn chọn lọc trên PPARδ thể hiện hiệu quả và ít tác dụng phụ trong điều trị rối loạn lipid huyết.

Mục tiêu: Xây dựng các mô hình pharmacophore cho chất chủ vận đa thụ thể trên PPARs và cho chất chủ vận đơn chọn lọc trên thụ thể PPARδ hướng điều trị rối loạn lipid huyết.

Đối tượng và phương pháp nghiên cứu: Mô hình pharmacophore cho các chất chủ vận trên thụ thể PPARs và chất chủ vận trên PPARδ được thực hiện dựa trên phối tử và cấu trúc sử dụng phần mềm MOE 2022.02.

Kết quả: Đối với chất chủ vận đơn chọn lọc trên PPARδ: có 2 mô hình pharmacophore được xây dựng là L-01 (dựa trên phối tử) gồm có năm điểm: một điểm vòng thơm, hai điểm kỵ nước và hai điểm nhận hydro và S-01 (dựa trên cấu trúc) có 4 tính chất là nhóm có khả năng hình thành liên kết cho hoặc nhận hydro; nhóm vòng thơm và kỵ nước. Đối với chất chủ vận trên cả ba thụ thể PPARs: một mô hình pharmacophore dựa trên phối tử được xây dựng gồm có 4 điểm với: 1 nhóm kỵ nước, 2 nhóm nhận hydro và một nhóm cho hydro. Các mô hình pharmacophore đều đạt các giá trị về độ nhạy, độ đặc hiệu, độ chính xác, chỉ số GH (goodness of hit score) và EF (enrichment factor)

Kết luận: Các đặc tính cần thiết cho chất chủ vận trên PPAR được nhận dạng qua mô hình pharmacophore.

Từ khóa: mô hình pharmacophore; PPAR; chất chủ vận trên PPARs; rối loạn lipid huyết
Az időskori demencia prediszponáló tényezőinek vizsgálata
Authors: Szentkereszty Kinga Emese , Csábi Eszter
Published: February 2025

Bevezetés: A demencia a 21. század népbetegsége, amely nagy terhet ró a családokra és az
egészségügyi ellátórendszerre egyaránt. A megnövekedett átlagéletkort figyelembe véve, előfordulásában nagymértékű növekedés várható, ezért a megelőzésnek fontos szerepe van. Korábbi kutatások a genetikai tényezők mellett, az életvitelt és a szellemi tevékenységek szerepét
emelték ki a demencia kialakulásának megelőzésében, illetve lefolyásában, ezért kutatásunk
célja az időskori kognitív működés, valamint az ezt befolyásoló faktorok feltérképezése.
Módszertan: A vizsgálatban összesen 40 fő vett részt [átlagélekor = 70,23 év (SD = ±3,97),
iskolai végzettség átlaga = 14,03 év (SD = ±8,97)]. A résztvevőkkel a Mini Mental Teszt
mellett egy olyan kognitív funkciókat mérő tesztcsomagot vettünk fel, amelynek során néztük a komplex munkamemóriát (Hallási Mondatterjedelem Teszt), a végrehajtó funkciókat
(Betű- és Szemantikus Fluencia Tesztek), a rövid- és hosszú távú memóriát (Számterjedelem
Teszt, Rivermead Viselkedéses Emlékezeti Teszt). Emellett kitöltésre került egy demográfiai
adatokat és életviteli szokásokat mérő kérdőív is (iskolázottság, aktív dolgozói státusz, nyelvismeret, párkapcsolati státusz, egészségügyi állapot).
Eredmények: Eredményeink alapján, a nyelvtudás, a magasabb iskolai végzettség, a párkapcsolati státusz és az aktív munkaviszony hatással volt az objektív, kognitív teszteken
nyújtott teljesítményre. Azok, akik magasabb iskolai végzettséggel rendelkeztek, párkapcsolatban éltek, legalább egy nyelven beszéltek, aktívan dolgoztak és sportoltak, jobb eredményeket értek el, főként a végrehajtó funkciókat mérő teszteken. Ezzel ellentétben, a cukorbetegség fennállása negatív hatással volt a kognitív teszteken nyújtott teljesítményre.
Következtetések: Következésképpen, eredményeink mélyebb betekintést engednek a kognitív alulműködést meghatározó protektív tényezőkre és rizikófaktorokra, valamint jó alapot
képezhetnek kognitív intervenciók, illetve adekvát rehabilitációs programok kidolgozására
idősek körében.
Analisis Pengendalian Kualitas Produk Muffler Sepeda Motor Menggunakan Metode Quality Control Circle (QCC) pada PT. XYZ
Authors: SEMNASTI Jeki Ajiantara , SEMNASTI Nida An Khofiyah , SEMNASTI Dwi Indra Prasetyac
Published: February 2025

PT. XYZ merupakan salah satu Perusahaan yang bergerak di bidang injection molding, jasa painting dan assembling. Dalam proses produksi muffler terdapat produk not good (NG) yang cukup banyak setiap bulannya. Jenis-jenis produk not good (NG) yang dibahas pada penelitian ini adalah lecet, spater, belang, kotor, meleleh, pasir, dan bruntus. Jumlah persentase NG yaitu 17,8% dari jumlah total produksi selama priode 2023. Penelitian ini bertujuan untuk mengetahui jenis - jenis NG apasaja yang sering terjadi pada produk muffler, faktor-faktor penyebab NG yang terjadi pada produk muffler, memberikan solusi perbaikan NG yang terjadi pada produk muffler, dan hasil perbaikan dengan menggunakan metode Quality Control Circle (QCC) dan 5W+1H pada produk muffler. Dengan melakukan kegiatan QCC diharapkan perbaikan kualitas akan terus berlangsung, agar kualitas semakin membaik. Hasil analisa dan perbaikan didapatkan adanya penurunan persentase NG yaitu 12,6% yang terjadi sebelum dan sesudah perbaikan produk muffler priode Januari sampai dengan Maret 2024. PT. XYZ mewajibkan setiap operator/pimpinan untuk menjalankan PKM (prinsip kerja PT. XYZ) apabila menemukan NG agar memisahkan part NG dan melakukan repair part NG yang sudah di pisahkan
Rancang Bangun Prototype Enterprise Resource Planning Pada Lumbung Pangan Desa di Komunitas Adat Bonekeling, Banyumas, Indonesia
Authors: SEMNASTI Ambarwati Puspita Sari , SEMNASTI Dhenis Aqira Maharani , SEMNASTI Ferdyansyah Irawan , SEMNASTI Fauzan Romadlon , SEMNASTI Shilfia Faradisa
Published: February 2025

Komunitas Adat Bonokeling merupakan salah satu komunitas adat di Banyumas, Jawa Tengah. Komunitas ini memiliki beberapa keunikan yang salah satunya adalah tradisi lumbung pangan. Tujuan lumbung pangan tersebut adalah mengupayakan ketahanan pangan masyarakat sekitar terutama di masa paceklik atau saat kondisi sosial tertentu seperti upacara adat. Faktanya, minimnya generasi muda dan proses bisnis yang masih sederhana menjadikan lumbung pangan perlu diperbaiki. Salah satu pendekatan untuk memfasilitasi gap tersebut yaitu dengan prototype Enterprise Resource Planning (ERP). Penelitian ini bertujuan mengadopsi ERP guna menjaga keberlangsungan tradisi lumbung pangan. Metode yang digunakan adalah kualitatif dengan pendekatan prototype dan data yang diperoleh digunakan untuk menyusun sistem ERP sesuai dengan kondisi lumbung pangan. Hasil dari penelitian menunjukkan bahwa pemanfaatan sistem ERP mampu membenahi sistem kelola sumber daya pada lumbung pangan menuju langkah dalam digitalisasi proses bisnis. Sistem ERP ini mencakup konsep-konsep administrasi, reporting, pengelolaan produk dan pemberdayaan sumber daya. Penelitian ini memiliki keterbatasan yaitu perlunya pengukuran readiness sebuah sistem digital. Pengukuran ini akan menggambarkan seberapa siap dan layak sebuah sistem diimplementasikan di lumbung pangan Komunitas Adat Bonokeling
Analisis Kebutuhan Customer Pada Pelayanan Aplikasi Ojek Online Wanita Di Madura
Authors: SEMNASTI Wisuda Yanti Simanjuntak , SEMNASTI Retno Indriartiningtias , SEMNASTI Samsul Amar , SEMNASTI Sabaruddin Akhmad , SEMNASTI Nova Meiriza
Published: February 2025

Masyarakat Madura merupakan masyarakat yang memegang erat nilai agama dan budaya keislaman. Nilai-nilai yang mereka yakini terlihat dari kebiasaan dan perilaku mereka sehari-hari termasuk dalam hal berinteraksi antara laki-laki dan Perempuan. Masyarakat Madura meyakini bahwa menjaga batas antara wanita dengan pria adalah hal yang harus dipatuhi. Termasuk dalam menggunakan transportasi ojek online saat ini. Saat ini telah ada dan mulai berkembang ojek online khusus wanita namun masih dipesan secara manual melalui grup Whatsapp. Berdasarkan beberapa fakta tersebut penulis ingin mengetahui preferensi customer ojek online khusus wanita yang nantinya bisa dikembangkan untuk merancang aplikasinya. Penelitian ini menggunakan metode kualitatif dengan melakukan studi literatur, wawancara dan penyebaran kuisoner pada pelanggan wanita selaku pengguna dari aplikasi yang akan dibuat. Hasil yang diperoleh melalui preferensi variabel ojek online wanita ialah berupa variabel kenyamanan dan variabel fitur aplikasi. Kenyamanan akan tercipta ketika fitur aplikasi mudah dimengerti dan diaplikasikan oleh customer. Kenyamanan yang diinginkan customer seperti driver yang ramah, driver menjemput tepat waktu, dan berkomunikasi dengan baik.
Analisis Pengendalian Risiko K3 dalam Proses Produksi Pembuatan Stator Dengan Metode Hazard Identification Risk Assesment Control (HIRARC) di Perusahaan Pembuat Komponen Otomotif
Authors: SEMNASTI Adi Rusdi Widya , SEMNASTI Supriyati Kusuma
Published: February 2025

Keselamatan dan Kesehatan Kerja (K3) merupakan elemen fundamental dalam menjaga kesehatan dan keselamatan pekerja serta meningkatkan produktivitas di tempat kerja, permasalahan meningkatnya kecelakaan kerja dan kurangnya kontrol risiko yang efektif dalam proses produksi memerlukan analisis potensi kecelakaan dengan menggunakan metode Hazard Identification Risk Assessment and Risk Control (HIRARC) dilakukan untuk mengurangi potensi kecelakaan. Tujuan dari penelitian adalah untuk menilai tingkat risiko dari bahaya yang diidentifikasi, mengembangkan metode pengendalian risiko, dan memastikan efektivitas penerapan HIRARC dalam mengurangi kecelakaan kerja . Hasil dari penelitian ini didapatkan analisis 30 potensi kecelakaan dengan risk assessment terdapat sebanyak 12 low risk, 13 moderate risk, dan 5 high risk. Kemudian diperolah empat jenis pengendalian risiko seseuai dengan hirarki pengendalian risiko yaitu personal protective equipment (PPE), administrative control, engineering control dan elimination. Setelah dilakukan pengendalian nilai risiko mengalami penurunan dengan tidak adanya risiko pada zero level very high risk, 3 moderate risk dan 27 low risk.
Pengembangan UMKM Kuliner Melalui Digital Payment Berdasarkan Preferensi Customer Dengan Metode SEM dan TOPSIS (Studi Kasus UMKM Kuliner Daerah Jombang)
Authors: SEMNASTI Eka Septiana Wulandari , SEMNASTI Retno Indriartiningtias , SEMNASTI Ernaning Widiaswanti , SEMNASTI Ida Lumintu , SEMNASTI Kukuh Winarso , SEMNASTI Sabarudin Akhmad
Published: February 2025

Perkembangan UMKM kuliner jombang saat ini mulai berkembang dengan pesat. Dengan hadirnya pembayaran non tunai dapat meningkatkan efisiensi dan meningkat keberhasilan suatu usaha UMKM. Penggunaan e-wallet saat ini dapat membantu konsumen lebih efektif, dan tidak perlu membawa uang cash. Namun pada UMKM kuliner daerah Jombang sebagian besar belum menggunakan pembayaran digital payment. Untuk mengatasi permasalahan ini maka dilakukan penelitian yang bertujuan untuk mengetahui minat penggunaan e-wallet pada konsumen UMKM kuliner daerah Jombang Kota. Penelitian ini menggunakan lima variabel eksogen yang terdiri dari variabel kemudahan, kepercayaan, kegunaan, resiko, dan promosi, sedangkan variabel endogen yaitu intention to transact online. Penelitian ini menggunakan metode Structural Equation Modelling yang digunakan untuk menentukan variabel yang mempengaruhi dalam pemilihan e-wallet. Hasil dari SEM akan digunakan untuk melakukan perangkingan e-wallet mana yang terbaik berdasarkan preferensi konsumen dengan menggunakan metode TOPSIS. Pengambilan data pada penelitian ini menggunakan kuesioner yang disebar secara offline, dengan kriteria sampel responden yang sudah pernah menggunakan e-wallet. Jumlah sampel pada penelitian ini menggunakan 125 responden. Hasil pengujian menggunakan SEM menunjukkan bahwa variabel yang signifikan terdiri dari variabel kepercayaan, kegunaan, promosi berpengaruh terhadap intention to transact online menggunakan e-wallet. Hasil analisis dari TOPSIS menunjukkan bahwa e-wallet yang terbaik ada Dana, selanjutnya ada Shopeepay, LinkAja, Gopay, dan Ovo.
The Blending ToolKit: A simulation framework for evaluation of galaxy detection and deblending
Authors: Mendoza Ismael , Torchylo Andrii , Sainrat Thomas , Guinot Axel , Boucaud Alexandre , Paillasa Maxime , Avestruz Camille , Adari Prakruth , Aubourg Eric , Biswas Biswajit , Buchanan James , Burchat Patricia , Doux Cyrille , Joseph Remy , Kamath Sowmya , Malz Alex I. , Merz Grant , Miyatake Hironao , Roucelle Cécile , Zhang Tianqing ,   LSST Dark Energy Science Collaboration
Published: February 2025

We present an open source Python library for simulating overlapping (i.e., blended) images of galaxies and performing self-consistent comparisons of detection and deblending algorithms based on a suite of metrics. The package, named Blending Toolkit (BTK), serves as a modular, flexible, easy-to-install, and simple-to-use interface for exploring and analyzing systematic effects related to blended galaxies in cosmological surveys such as the Vera Rubin Observatory Legacy Survey of Space and Time (LSST). BTK has three main components: (1) a set of modules that perform fast image simulations of blended galaxies, using the open source image simulation package GalSim; (2) a module that standardizes the inputs and outputs of existing deblending algorithms; (3) a library of deblending metrics commonly defined in the galaxy deblending literature. In combination, these modules allow researchers to explore the impacts of galaxy blending in cosmological surveys. Additionally, BTK provides researchers who are developing a new deblending algorithm a framework to evaluate algorithm performance and make principled comparisons with existing deblenders. BTK includes a suite of tutorials and comprehensive documentation. The source code is publicly available on GitHub at https://github.com/LSSTDESC/BlendingToolKit.
Strategy of Traditional traders at Panorama Market Bengkulu City in Facing Challenges of E-Commerce
Authors: Safas Putri Nikmah , Safitra Linda , Ayu Wijayanti
Published: February 2025

Abstrak
Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis dampak e-commerce terhadap struktur dan fungsi pedagang tradisional di Pasar Panorama, Kota Bengkulu, serta strategi yang mereka gunakan untuk menghadapi tantangan tersebut. Menggunakan teori fungsionalisme struktural oleh Robert K. Merton, penelitian ini mengeksplorasi bagaimana setiap komponen dalam sistem sosial saling berfungsi dan berkontribusi terhadap kelangsungan sistem. Metode penelitian yang digunakan adalah observasi langsung dan wawancara mendalam dengan para pedagang tradisional. Hasil penelitian menunjukkan bahwa e-commerce memaksa pedagang tradisional untuk beradaptasi dengan teknologi baru dan preferensi konsumen yang berubah, meningkatkan efisiensi dalam hal biaya dan waktu. Namun, adanya promosi besar dari e-commerce menyebabkan penurunan pengunjung dan penjualan di pasar tradisional serta kesulitan dalam mengadopsi teknologi baru yang menimbulkan tekanan psikologis dan isolasi. Beberapa pedagang beradaptasi dengan menggunakan media sosial dan platform e-commerce untuk menjangkau lebih banyak pelanggan dan tetap bersaing. Kesimpulannya, meskipun e-commerce membawa tantangan signifikan bagi pedagang tradisional, strategi adaptasi yang tepat dapat membantu mereka bertahan dan bahkan berkembang di era digital ini.
 
Kata Kunci: E-commerce, Pedagang, Strategi, Tantangan, Tradisional
“TANDUSNYA” BUDAYA BACA (Studi Kasus Pada Mahasiswa/i Sosiologi 2012 Fakultas Ilmu Sosial dan Ilmu Politik, Universitas Bengkulu)
Authors: Oktoviansyah Sugian , Purwaka Purwaka , Widiono Sumarto
Published: February 2025

Penelitian ini dilatarbelakangi oleh kosongnya budaya membaca di kalangan Mahasiswa Sosiologi 2012. Realitas memperlihatkan bahwa Mahasiswa Sosiologi 2012 tidak membiasakan dirinya melakukan aktivitas membaca bacaan yang mendukung studinya di Jurusan Sosiologi selama beraktivitas di kampus maupun di luar kampus. Tujuan penelitian ini untuk mendeskripsikan penyebab tidak terciptanya budaya membaca bacaan yang mendukung studi Mahasiswa Sosiologi 2012 di Jurusan Sosiologi. Penelitian ini menggunakan Metode Kualitatif-Deskriptif dengan penerapan Snowball Sampling. Pengumpulan data dilakukan dengan cara mengobservasi aktivitas Mahasiswa/i Sosiologi 2012 dalam ruang lingkup kampus maupun di luar kampus dan wawancara mendalam terhadap 8 Informan. Analisis data dilakukan secara simultan bersamaan dengan proses pengumpulan data dengan menggunakan teknik yang lazim berlaku dalam Penelitian Kualitatif yang meliputi reduksi data, penyajian data dan sampai pada penarikan kesimpulan. Hasil penelitian menunjukkan bahwa kondisi belajar yang terjadi di kelas Sosiologi 2012 sangat mengakar kuat metode mendengar di dalamnya, sehingga Mahasiswa/i Sosiologi 2012 menjadikan aktivitas mendengar sebagai cara belajar dibanding membaca, hal tersebut juga dipengaruhi oleh latar belakang proses belajar Mahasiswa/i Sosiologi 2012 pada tingkat pendidikan dasar dan menengah yang cenderung pada budaya mendengar. Di sisi lain budaya instan seperti copy-paste tugas kuliah telah menjadi cara berpikir dan bertindak Mahasiswa/i Sosiologi 2012 dalam belajar, walaupun sudah dipacu oleh dosen Sosiologi dengan berbagai tugas kuliahbaik bersifat individu maupun kelompok. Hal tersebut mengakibatkan Mahasiswa Sosiologi 2012 merasa tidak memiliki beban dalam belajar, sehingga lebih mengisi waktu mereka dengan aktivitas hiburan seperti membaca bacaan-bacaan hiburan dan populer. Kata Kunci: Kondisi Aktivitas Belajar di Kelas, Aktivitas Mendengar, Copy-Paste Tugas dan Bacaan Hiburan dan Populer.
DINAMIKA KEHIDUPAN PEREMPUAN PENYADAP KARET DI WILAYAH KONFLIK SAWIT PADA MASA PANDEMI COVID-19
Authors: Yuliana Yuliana
Published: February 2025

Tulisan ini merupakan hasil penelitian terhadap perempuan penyadap karet di Desa Janah Jari, Kecamatan Awang, Kabupaten Barito Timur, Kalimantan Tengah, yang dilakukan bersama lembaga JPIC (Justice, Peace and Integrity for Creation) Kalimantan. Penelitian ini mempertanyakan bagaimana peran yang dijalankan perempuan penyadap karet di Desa Janah Jari yang hidup di wilayah konflik sawit pada masa pandemi Covid-19. Tujuan penelitian mendeskripsikan: (1) dampak kehadiran perusahaan sawit PT Ketapang Subur Lestari terhadap ruang hidup perempuan (2) konflik laten yang terjadi di masyarakat (3) peran perempuan penyadap karet dimasa pandemi Covid-19. Penelitian dilakukan dengan metode kualitatif, teknik pengumpulan data observasi dan wawancara. Analisis data menggunakan model Miles dan Huberman. Adapun hasil penelitian: (1) ruang hidup perempuan berupa hutan dan sungai untuk memenuhi kebutuhan sehari-hari kini menyempit. (2) Masyarakat masih merasa kecewa, serta marah dengan pihak perusahaan sawit PT Ketapang Subur Lestrari yang tak peduli dengan kondisi ruang hidup mereka. (3) Terdapat peran reproduktif dan peran produktif, dan beban kerja sebagai bentuk perjuangan kehidupan bagi keluarga mereka. Adapun kesimpulan penelitian bahwa kehadiran perkebunan kelapa sawit dan pandemi Covid-19 sama-sama membawa perubahan pada kehidupan sosial (budaya) dan ekonomi perempuan penyadap karet yang berdampak pada beban kerja perempuan penyadap karet yaitu memberikan alokasi waktu lebih untuk menjalankan peran reproduktif dan peran produktif.Kata Kunci :  Perempuan Penyadap Karet, Konflik Sawit, Pandemi Covid-19
GERAKAN SOSIAL EKS HIZBUT TAHRIR INDONESIA PASCA PEMBUBARAN (Studi Kasus di Bengkulu)
Authors: Yunarman Sepri , Fhadilah Nurul , Akbarjono Ali
Published: February 2025

Gerakan reformasi pada tahun 1998 telah membuka kran kebebasan sosial politik bagi warga negara Indonesia. Akibatnya, animo masyarakat untuk mendirikan ormas sebagai wadah perkumpulan, baik perkumpulan sosial, ekonomi, politik dan keagamaan sangat tinggi. Salah satu ormas yang mengambil peran di era kebebasan tersebut adalah Hizbut Tahrir Indonesia (HTI). Namun di dalam perjalanannya, kegiatan yang dilaksanakan HTI banyak berbenturan dengan banyak pihak, baik dari kelompok Islam itu sendiri maupun dengan rezim pemerintah. Pada akhirnya presiden Joko Widodo resmi mengeluarkan Peraturan Pemerintah Pengganti Undang-Undang Nomor 2 tahun 2017 tentang pembubaran HTI. Akan tetapi, meskipun telah dibubarkan oleh pemerintah, banyak hipotesis yang menunjukkan bahwa gerakan sosial eks HTI masih tetap berjalan. Penelitian ini bertujuan untuk mengkaji bagaimana eksistensi gerakan sosial eks HTI setelah dibubarkan, bagaimana tahapan-tahapan gerakan sosial yang dibangun serta bagaimana pola-pola gerakan sosial eks HTI khususnya di Provinsi Bengkulu. Penelitian ini menggunakan pendekatan kualitatif bersifat penelitian lapangan. Metode pengumpulan data dengan wawancara mendalam, observasi dan dokumentasi. Selanjutnya dianalisis menggunakan model Miles dan Hubberman melalui tiga tahap, reduksi data, penyajian data serta penarikan kesimpulan. Hasil penelitian menemukan eksistensi gerakan sosial eks HTI di Bengkulu masih aktif. Mereka tetap melakukan kegiatan meskipun masih masa pandemi, namun lebih banyak daring daripada tatap muka. Adapun pola gerakan sosial eks HTI bersifat ekspresif, reformatif serta perlawanan. Tahap-tahap gerakan sosial eks HTI, pendirian lembaga, framing isu, proses pengkaderan, pemberdayaan anggota dan penguasaan Negara. Dari hasil kajian, belum terlihat kegiatan eks HTI yang mengarah pada tindakan membahayakan NKRI. Namun pemerintah perlu mengedukasi dan mengawasi komunitas-komunitas yang ada agar kegiatan eks HTI tidak melenceng dari nilai Pancasila dan UUD 1945.Kata Kunci : Gerakan Sosial, Eks HTI, Provinsi Bengkulu
Dual Band Microstrip Antenna
Authors: Ise Juan Eduardo , Hemsy Axel , Fagre Mariano , Miranda Bonomi Fernando Alberto , Cabrera Miguel Angel , Scandaliaris Jorge
Published: February 2025

The amount of data in today’s communication systems is increasing considerably, which in turn increases the bandwidth needed to deploy a given service. This requires antennas that are capable of operating simultaneously in more than one band. In this work we present the modeling and development of a rectangular patch type dual band antenna operating at 900 and 1800 MHz. To achieve this, the antenna is modeled as a resonant cavity with electric walls on the upper and lower faces and magnetic walls on the sides. To achieve dual band operation shorting pins are used which allow the fundamental resonant frequency of the antenna to be adjusted to the desired value. The design is analyzed by simulation with the electromagnetic computational tool CST. Measurements carried out on a prototype show a return loss of less than -23 dB, a bandwidth of 22 MHz in the lower band and 60 MHz in the upper band for a SWR less than or equal to 2 and a directivity greater than 7 dBi. We can argue that the antenna presents good characteristics for its operation in current systems.
Discinesia escapular e sua influência nas síndromes dolorosas do ombro: uma revisão narrativa
Authors: Dalamaria Júnior Maurício
Published: February 2025

Este estudo busca investigar se essa condição pode ser considerada um fator preditivo para o desenvolvimento de tais síndromes, contribuindo para estratégias mais eficazes de prevenção e reabilitação. Esta pesquisa analisou a relação entre a discinesia escapular e condições dolorosas do ombro, como a síndrome do impacto. A discinese, caracterizada pelo deslocamento irregular da escápula durante a movimentação do úmero, pode contribuir para alterações biomecânicas e possíveis danos estruturais. Sua avaliação clínica inclui inspeção estática e dinâmica, permitindo a identificação de padrões disfuncionais que orientam estratégias de reabilitação, como fortalecimento e alongamento muscular. A revisão de estudos publicados entre 1990 e 2024 indicou que, embora a discinese possa representar um fator de risco para a síndrome do impacto, sua presença não é determinante, podendo também resultar de adaptações mecânicas à dor preexistente. Assim, a abordagem clínica deve considerar tanto sua influência no desenvolvimento de disfunções quanto seu papel como resposta adaptativa. Esta pesquisa contribui teoricamente para a compreensão mais ampla da discinesia escapular e, na prática, fornecer subsídios para aprimorar a avaliação e a intervenção profissional. Conclui-se que a identificação precoce e a reabilitação adequada são fundamentais para minimizar os impactos da discinesia e otimizar a funcionalidade do ombro.
Etnobiologi Dan Interdependensi Masyarakat Terhadap Kawasan Konservasi (Studi Masyarakat Sekitar Taman Wista Alam Klamono Papua Barat Daya)
Authors: Maruapey Azis , Nanlohy Lona Helti , Saeni Fajrianto
Published: February 2025

As a conservation area, the Klamono Nature Tourism Park is also expected not only for tourism purposes, but also as a life support area for the surrounding community who are dependent on natural resources, both wood and non-timber forest products. The method used in this research is a descriptive method with survey techniques and semi-structural interviews. The results of the research show communally that the community in utilizing the Klamono Nature Tourism Park conservation area is farming, hunting and gathering which is of ethnobiological significance and interdependence (dependence) on the availability of forest resources in the park area. Ethnobiology and community interdependence are interpreted by the perception that forests are a source of food, forests are a source of medicines, forests are a source of building materials, forests are a source of firewood and forests are a source of cash income.
PERANAN DPA (DESIGNATED PERSON ASHORE) SEBAGAI UPAYA PENERAPAN ISM CODE (INTERNATIONAL SAFETY MANAGEMENT CODE) DALAM MENGIMPLEMENTASIKAN SAFETY MANAGEMENT SYSTEM DI PERUSAHAAN PELAYARAN DAN KAPAL
Authors: Guritno Suryo , Weda Iwan
Published: February 2025

Peran utama Designated Person Ashore adalah bertanggung jawab atas manajemen keselamatan kapal, dan mengkoordinasikan kajian dan kegiatan verifikasi sistem manajemen keselamatan, baik di darat maupun di laut, dan melaporkan secara formal pada proses kajian ulang manajemen mengenai kinerja sistem. Designated Person Ashore memiliki pertanggungjawaban dalam melaksanakan pengawasan seluruh kegiatan operasional kapal serta berperan serta dalam upaya pencegahan pencemaran lingkungan laut dari kapal selain itu harus mampu menjalin komunikasi yang efektif dan efisien antara pemimpin tertinggi di perusahaan dengan awak kapal dalam seluruh kegiatan operasional kapal. Adapun yang menjadi tujuan penulisan jurnal ini adalah untuk memberikan informasi mengenai bagaimana Designated Person Ashore itu sendiri, selain memberikan tambahan pengetahuan tentang peranan dan tanggungjawab seorang Designated Person Ashore terhadap Perusahaan pelayaran dan kapal dalam kaitannya dengan faktor keselamatan. Peranan Designated Person Ashore ini sangat besar dalam melaksanakan pengawasan seluruh kegiatan operasional kapal dan pencegahan pencemaran dari kapal selain sebagai   penghubung (Representatif) antara pimpinan tertinggi di perusahaan dengan awak kapal dalam segala kegiatan operasional kapal.
TRANSFORMASI ORGANISASI UNIT KERJA PENGADAAN BARANG DAN JASA PEMERINTAH DAERAH KABUPATEN BUTON TENGAH
Authors: Indrawan La Ode Syarif , Islamy La Ode Syaiful , Abidin Zainul
Published: February 2025

Organizational transformation is a form of change to encourage organizations to be able to adapt to public demands and organizational needs. Organizational transformation goes through three stages, namely unfreezing, changing, and refreezing. The purpose of the research is to explain the organizational transformation process of the Goods and Services Procurement Work Unit of the Central Buton Regency in realizing transparency. The research method is qualitative descriptive with three data collection methods, namely interviews, observations, and documentation. The results of the study show that the introduction stage of organizational transformation is carried out through the introduction process, both organizational structure, human resource recruitment and employee work management. Furthermore, the stage of organizational change of UKPBJ in Central Buton district is carried out with a gradual process, so that its implementation has encouraged the procurement of goods and services that are accountable, transparent and responsive. Furthermore, this Refreezing Stage  aims to strengthen and accept the changes that have been made so that they become new habits and are embedded in the organizational culture. In general, it can be concluded that organizational transformation encourages good organizational governance and the success of transformation is greatly influenced by the commitment of leaders in the regions.
Mobile Health Interface Analysis: Usability Assessment of the Sembada Application for Non-Communicable Disease Monitoring
Authors: Wijayanti Dian , Kurdanti Weni , Siswati Tri
Published: February 2025

Background: Early detection of non-communicable diseases (NCDs) through integrated guidance posts (Posbindu PTM) can be enhanced through mobile health applications. This study aimed to develop and evaluate the usability of Sembada m-Health, an Android-based application for conducting Posbindu PTM activities at Sleman Regional General Hospital. Methods: This Research and Development study employed the Four D model (Define, Design, Develop, Disseminate). The define phase involved stakeholder needs assessment through Focus Group Discussions. The design phase encompassed application development by IT experts, while the develop phase included multi-level testing by material experts (n=2), media experts (n=2), and end-users (n=30). Structured questionnaires assessed media and material aspects, while the Post-Study System Usability Questionnaire (PSSUQ) evaluated user experience. The disseminate phase included application socialization and qualitative evaluation. The study was conducted in Yogyakarta from October 2021 to April 2022, with feasibility thresholds set at ≥4.20 for media and material aspects and ≤2.82 for PSSUQ. Results: The application exceeded all feasibility thresholds, scoring 4.62 for media aspects, 4.23 for material aspects, and 1.71 on the PSSUQ. Stakeholders expressed high satisfaction with Sembada m-Health's system functionality, particularly its support for individual health monitoring, program implementation, NCD risk factor tracking, and personalized recommendations. Conclusions: Sembada m-Health demonstrated high usability and feasibility for supporting the Posbindu PTM program. Future research should focus on evaluating its long-term impact on NCD prevention and management outcomes.
Effect of Stunting Prevention Health Counseling Using Animated Videos on the Knowledge of Brides-to-Be
Authors: Putra Ardhi Wiratama , Putri Dian Utama Pratiwi , Noviansyah Noviansyah
Published: February 2025

Background: In Indonesia, the prevalence of stunting remains a pressing issue, with rates still considerably high and far from achieving the national target of 14%. One of the critical strategies in addressing this problem is providing adequate education and information to brides-to-be (Catin) regarding pregnancy planning and childcare as a preventive measure against stunting. This study aims to analyze the impact of stunting prevention health counseling using animated video media on improving the knowledge of brides-to-be. Methods: The study involved 60 brides-to-be attending counseling sessions at the BKKBN KB Counseling Center in Rajabasa District, South Lampung Regency. A pre-test and post-test design was utilized to measure changes in knowledge levels. Results: The results showed that prior to the intervention, 25 participants (41.7%) demonstrated good knowledge about stunting prevention. Following the counseling sessions, this number increased significantly to 58 participants (96.7%). Statistical analysis revealed a p-value of 0.0001 (p < 0.05), confirming a significant effect of the intervention. Conclusions: The study highlights the effectiveness of animated video media in delivering health education due to its ability to present information in an engaging, visual, and emotional format. This approach not only enhances comprehension but also sustains interest, making it a valuable tool for increasing awareness and knowledge about stunting prevention among brides-to-be. Strengthening such initiatives can contribute significantly to achieving the national stunting reduction target in Indonesia.
A chronological history of heart valve prostheses to offer perspectives of their limitations
Authors: Evangelista Raquel Ahnert Aguiar , Pires Ana Luiza Resende , Nogueira Breno Valentim
Published: February 2025

Prosthetic heart valves (PHV) have been studied for around 70 years. They are the best alternative to save the life of patients with cardiac valve diseases. However, current PHVs may still cause significant disadvantages to patients. In general, native heart valves show complex structures and reproducing their functions challenges scientists. Valve repair and replacement are the options to heal heart valve diseases (VHDs), such as stenosis and regurgitation, which show high morbidity and mortality worldwide. Valve repair contributes to the performance of cardiac cycles. However, it fails to restore valve anatomy to its normal condition. On the other hand, replacement is the only alternative to treat valve degeneration. It may do so by mechanical or bioprosthetic valves. Although prostheses may restructure patients’ cardiac cycle, both prostheses may show limitations and potential disadvantages, such as mechanical valves causing thrombogenicity or bioprosthetic valves, calcification. Thus, prostheses require constant improvements to remedy these limitations. Although the design of mechanical valve structures has improved, their raw materials cause great disadvantages, and alternatives for this problem remain scarce. Cardiac valve tissue engineering emerged 30 years ago and has improved over time, e.g., xenografts and fabricated heart valves serving as scaffolds for cell seeding. Thus, this review describes cardiac valve substitutes, starting with the history of valvular prosthesis transplants and ending with some perspectives to alleviate the limitations of artificial valves.
Specific gut microbiota and serum metabolite changes in patients with osteoarthritis
Authors: Wang Wendong , Liu Xincheng , Nan Hao , Li Huan , Yan Litao
Published: February 2025

Introduction

Recent research indicated a strong link between the gut microbiota and osteoarthritis. However, the complex interplay between the gut microbiota, serum metabolites, and the progression of osteoarthritis in affected individuals remains largely unexplored. This study aimed to investigate the characteristics of the gut microbiota and serum metabolites in patients with osteoarthritis.

Methods

Participants with either healthy knees or osteoarthritis were enrolled and categorized into healthy control (HC) and osteoarthritis (OA) groups. Fecal and blood samples were collected for 16S rRNA gene sequencing, metabolomic analysis via liquid chromatography–mass spectrometry (LC-MS), and integrated evaluation.

Results

The results showed no significant variation in gut microbiota richness and diversity between the two groups. However, the abundance of Bacteroides plebeius and Faecalibacterium prausnitzii was reduced in the OA group, both of which are known for their potential as next-generation probiotics for human health. Metabolomic analysis indicated that serum metabolites, including pyrogallol and 3-hydroxybutyrate (3HB), were significantly lower in the OA group. These metabolites are known to positively impact osteoarthritis progression and other diseases and demonstrated good diagnostic performance for distinguishing osteoarthritis patients from healthy controls. Correlation analysis revealed a positive correlation between Bacteroides plebeius and Faecalibacterium prausnitzii and between pyrogallol and 3HB.

Discussion

This study highlighted specific gut microbiota and serum metabolite profiles in osteoarthritis patients, suggesting that the specific changes in bacteria and derived metabolites are closely tied to osteoarthritis progression. This underscores the potential of gut microbiota and serum metabolites as modifiable elements and therapeutic targets for osteoarthritis prevention.
Enhanced invasion and survival of antibiotic- resistant Klebsiella pneumoniae pathotypes in host cells and strain-specific replication in blood
Authors: Klaper Kathleen , Pfeifer Yvonne , Heinrich Lena , Prax Marcel , Krut Oleg , Bekeredjian-Ding Isabelle , Wahl Anika , Fischer Martin A. , Kaspar Heike , Borgmann Stefan , Gerlach Roman G. , Werner Guido
Published: February 2025

Background

Klebsiella pneumoniae is one of the most important opportunistic pathogens causing healthcare-associated and community-acquired infections worldwide. In recent years, the increase in antibiotic resistance and infections caused by hypervirulent K. pneumoniae poses great public health concerns. In this study, host-pathogen interactions of different K. pneumoniae strains of human and animal origins were analyzed in microbiological, cell-biological and immunological experiments.

Methods

In vitro infection experiments using representatives of different K. pneumoniae pathotypes and various epithelial and macrophage cell lines were executed analyzing adhesion, invasion and intracellular replication. Experimental conditions involved normoxia and hypoxia. Furthermore, survival and growth of further K. pneumoniae isolates expressing defined siderophores in blood (platelet concentrates, serum) was investigated. All experiments were done in triplicate and statistically significant differences were determined.

Results

Significant differences in adhesion and invasion capability, phagocytosis resistance and intracellular replication were measured between different K. pneumoniae pathotypes. Especially, ESBL-producing K. pneumoniae isolates demonstrated increased invasion in host cell lines and survival in macrophages. A strong cytotoxic effect on intestinal cells was observed for hypervirulent K. pneumoniae. The results from our investigations of the growth behavior of K. pneumoniae in platelets and serum showed that siderophores and/or an enlarged capsule are not essential factors for the proliferation of (hypervirulent) K. pneumoniae strains in blood components.

Conclusion

Our in vitro experiments revealed new insights into the host-pathogen interactions of K. pneumoniae strains representing different pathovars and clonal lineages in different infectious contexts and hosts. While a clear limitation of our study is the limited strain set used for both infection and as potential host, the results are a further step for a better understanding of the pathogenicity of K. pneumoniae and its properties essential for different stages of colonization and infection. When developed further, these results may offer novel approaches for future therapeutics including novel “anti-virulence strategies”.
Cell signaling in Ehrlichia infection and cancer: Parallels in pathogenesis
Authors: Solomon Regina N. , Pittner Nicholas A. , McCoy Jaclyn R. , Warwick Paityn A. , McBride Jere W.
Published: February 2025

Ehrlichia chaffeensis (E. chaffeensis) has recently emerged as an intracellular bacterial pathogen with sophisticated survival mechanisms that include repurposing evolutionarily conserved eukaryotic cell signaling pathways for immune evasion. E. chaffeensis exploits four major developmental signaling pathways (Wnt, Notch, Hedgehog, and Hippo) using short linear motif (SLiM) ligand mimicry to initiate signaling cascades. Dysregulation of these major signaling pathways leading to unchecked cell survival is implicated in various diseases, most notably cancer. E. chaffeensis exploits Wnt, Notch, Hedgehog and Hippo signaling pathways to inhibit apoptosis and co-opt other cellular functions to promote infection. This review will explore the signaling pathways exploited during Ehrlichia infection and the new discoveries that have illuminated this interesting example of the cell signaling convergence in cellular infection and cancer biology.
Global burden of reported lower respiratory system fungal infection
Authors: Wang Zheng , Pan Mengshu , Zhu Jie
Published: February 2025

Background

The epidemiological trend of lower respiratory tract fungal infections remains unclear. This study aims to quantify the global burden of these infections from 1990 to 2021 using data from the Global Burden of Disease Study 2021.

Methods

Data were analyzed at global, regional, and national levels, considering factors such as age, gender, region, and socio-demographic index (SDI). Key indicators included age-standardized disability-adjusted life-year (ASDR) and age-standardized mortality rates (ASMR).

Results

On a global scale, the burden of lower respiratory fungal infections decreased significantly from 1990 to 2021, with a decline in mortality rates. Regionally, substantial disparities were observed among the 21 geographic super-regions. Nationally, Argentina experienced the greatest increase in ASDR and ASMR, while Finland showed the largest decrease, with average annual percentage changes (AAPC) below -5 for both indicators. Sex-based analysis revealed a notably higher burden in males compared to females. ASDR and ASMR were negatively correlated with SDI in most regions.

Conclusion

Although the global burden of lower respiratory tract fungal infections has decreased, it remains a substantial public health issue, particularly in low-SDI regions. There is an urgent need to implement targeted preventive measures to address this ongoing challenge.
Unveiling the threat of crystalline silica on the cardiovascular system. A comprehensive review of the current knowledge
Authors: Gurzu Irina Luciana , Handra Claudia Mariana , Ghita Isabel , Otelea Marina Ruxandra
Published: February 2025

Introduction

This paper aims to expose the link between occupational exposure to respirable crystalline silica (SiO2) and cardiovascular diseases (CVDs).

Methods

A comprehensive review of the literature was conducted, focusing on epidemiological studies that assessed the association between silicosis or SiO2 exposure and CVDs. Specific cardiovascular diseases, such as acute myocardial infarction, arrhythmias, pulmonary hypertension and pericarditis, were also pointed. Biomarkers commonly used in both silicosis and cardiovascular diseases were reviewed to underline the common pathological pathways.

Results

Published epidemiological data revealed a higher risk of ischemic heart disease, stroke, and hypertension in silica-exposed workers, even at low exposure levels. SiO2 exposure was linked to an increased risk of myocardial infarction, with potential mechanisms involving inflammation and platelet activation. Elevated risk of arrhythmias, particularly atrial fibrillation, correlated with occupational silica exposure. Consistent with the pathological mechanisms supporting the SiO2 exposure—CVDs relationship, biomarkers related to NLP3 inflammasome activation, reflecting oxidative stress, and revealing fibrosis have been presented.

Conclusion

Actual data support the relationship between occupational SiO2 exposure and various CVDs promoting cardiovascular monitoring in silica-exposed workers. Further studies are needed to identify specific/distinctive biomarkers to improve early detection of CVDs in silica exposed workers.
Case Report: Delayed diagnosis: a case of left main coronary artery spasm
Authors: Zhi Yaxin , Sun Wei , Zhang Ziqiao , Liu Demin
Published: February 2025

Left main coronary artery (LMCA) spasm is an exceedingly rare but potentially fatal condition. We present a case of severe stenosis of LMCA found by coronary angiography (CAG) due to recurrent chest pain, and subsequently received coronary artery bypass grafting (CABG). Nine years later, the patient was readmitted to the hospital because of precordial discomfort. During hospitalization, CAG was performed once again and showed no significant stenosis in the LMCA, leading to the diagnosis of LMCA spasm. This case emphasizes to interventional cardiologists the critical need to consider the possibility of LMCA spasm when diagnosing LMCA lesions. It highlights the importance of thorough and proactive pretreatment and comprehensive clinical judgment to minimize the risk of misdiagnosis.