bluuebunny/crossref_metadata_2025 huggingface dataset:
License Plate Recognition for Traffic Management
Authors:   Amity School of Engineering and technology, Amity University, Lucknow, India, Singh Astha , Singh Pawan ,   Amity School of Engineering and technology, Amity University, Lucknow, India
Published: August 2022

The objective of this report is to present an overview of the project, license plate recognition. This system is to basically detect a vehicle using the information of the license plate in order to use the information at various valid sites. This tool can work as a part of other big projects in the industry for security purposes as well as for analysis purposes. There is a detailed insight of the project in several different chapters throughout the report. This project is based on detection and recognition algorithms; using several libraries of python to work on images and videos and thereafter using the processed image to further train and test a model using machine learning algorithm such that the recognition is done with higher accuracy. The beginning outlines the introduction to the topic and its importance in the real world by highlighting some other applications using similar approach. Later it highlights the technology and skills in use in order to completely deploy the idea. Further there is an explanation to the feasibility study as well as the requirement specification while system design revolves around the basic designing of several modules which would integrate to work as the whole system and test cases. Implementation and testing approach is being discussed and thereby light has been thrown on the results and conclusion thus bringing attention to system’s limitation and its future scope.
Fake News Detection using Machine Learning: A Comprehensive Analysis
Authors:   Amity School of Engineering and Technology, Amity University, Lucknow, India, Kushwaha Nidhi Singh , Singh Pawan ,   Amity School of Engineering and Technology, Amity University, Lucknow, India
Published: August 2022

Fake news today is an important fact or the life of social media and in the political world. False news discovery is an important study that should be done for its discovery but there are some challenges as well. Some challenges may be due to the small number of similar resources available collection of data and publications. We suggest in this paper, the discovery of false information using machine learning techniques. We compare three different stages of machine learning strategies. Not only that, but we will be working with three different models namely Logistic Regression, Decision Tree Classifier, and Random Forest Classification. According to the discovery of our project, we have gained your various accuracy each way in sequence. Our project can greatly benefit from finding out if the given information is true or fake.
Security Issues in Cloud Computing
Authors:   Amity School of Engineering & Technology, Amity University Uttar Pradesh, Lucknow, India, Srivastava Aryan , Singh Pawan ,   Amity School of Engineering & Technology, Amity University Uttar Pradesh, Lucknow, India
Published: August 2022

Cloud computing has aided the evolution of IT by improving the ability and flexibility of data storage, as well as providing scalable computation and processing capabilities that match the dynamic data sets. Many corporate application programs have been transferred to public and hybrid clouds due to the multiple benefits of cloud computing. On the other hand, many businesses identify privacy and data security as major concerns that prevent them from adopting cloud computing. The only way to achieve successful cloud implementation is to improve and manage data security and privacy in the cloud. This research paper looks at data privacy and security in cloud computing at all stages of the data lifecycle, providing a general overview of the technology while highlighting important security difficulties and concerns that must be addressed. It also examines a number of existing solutions and gives recommendations for new ones that can improve data privacy and security in the cloud. Finally, future research on data privacy and security in cloud systems is discussed in the study report.
Study of Language Models: Evolution & Limitations
Authors:   Amity School of Engineering and technology, Amity University, Lucknow, India, Gupta Aayush Kumar , Rizvi Sheenu ,   Amity School of Engineering and technology, Amity University, Lucknow, India
Published: August 2022

We have come far from the days when rule-based language models used to be the predominant thing in the market. Machine Learning came into play and changed the Language Model industry. In this paper, we will look at how RNN did a much better task for generating output based on its previous results and then how LSTM fulfilled the memory requirement for RNN. Also, we will take a look at how Transformer is much better than RNN combined with LSTM, which is the state-of-the-art language model on which the two best natural processing models like BERT and GPT3.
FRP Material for the Performance of Bridge Components Reinforcement and Improvement
Authors: Deng Yukuan , Fan Wenxuan , Wang Ruqin , Xue Donglin
Published: August 2022

Most bridges today suffer from ageing as a result of increased uses and the erosion of the natural environment. Engineers often need to focus on the actual strengthening needs in the projects they design, as each method has its own limitations and applicability, and there are gaps in the strengthening and improvement methods for various bridge elements. This paper provides a synthesis of some methods of strengthening bridge elements to facilitate comparison and discussion during construction. The application of Fiber Reinforced Polymer (FRP) materials in bridge engineering is then explored and the different types of FRP materials are compared. The results show that the strengthening methods are more suitable for each bridge member. For bridge decks, the analysis of various FRP reinforcement test results and crack extensions lead to the conclusion that the FRP reinforcement is closer to the modulus of elasticity of concrete and has better coordination of deformation, making it a splitting of concrete. However, when discussing the strengthening of bridge girders and pier members, the type of damage that occurs under different damage and loads is different. Therefore, there are different options and methods for different types of FRP materials.
Risk Analysis of Fire Disaster in Modern Warehousing System Based on The Data of Idealized Transit Warehouse
Authors: Zhang Ying , Huang Gefei
Published: August 2022

In the modern logistic system, the modern warehouse plays an important part in it, affording more functions than just storage. Fire disaster is one of the most common disasters in the modern warehouse, causing huge problems. It is necessary to protect the security of the modern warehouse by specific measures. This study takes a modern logistics transit warehouse as an example, and mainly discusses the fire risk probability in the different areas and the total fire disaster risk assessment using the total probability formula and Gustav civil fire risk analysis method. This study uses the actual data of the warehouse itself and some quantitative methods to calculate parameters indicating the fire risk of goods and people in the Gustav method, and puts them together for a final assessment. Results show that the main storage area have the highest risk for both facilities and stuff, even though the whole warehouse is relatively safe. Finally, this study gives out some practical suggestions for this kind of warehouse, mainly in the aspects of the completeness of fire warning system and Installation of fire-fighting facilities.
Evaluation and Improvements Of Epidemic Prevention And Control: A Case Study In Haikou And Harbin Cities
Authors: Miao Shuqi , Zhang Zidong
Published: August 2022

In today’s COVID-19 era, cities, where residents do not maintain proper social distancing in public spaces, are more vulnerable to the outbreak. In order to investigate social distancing and the symbiotic relationship between urban public spaces and the factors of the spread of the epidemic, this paper selects Haikou and Harbin cities to analyze their current situation of external residential and commercial street public areas through questionnaires, discusses their commonalities and differences in the process of epidemic prevention and control, and proposes design interventions. Results show that Haikou people prefer to go out collectively through public transport, do not pay attention to maintaining social distance, and most people do not have good epidemic prevention habits. The enthusiastic Harbin residents tend to chat with the shop assistants and don't have the habit of keeping a social distance and wearing masks. Facing COIVD-19, their commonalities in poor epidemic prevention mainly reflect three aspects: the streets of both belong to the more closed and narrow streets of the old city, the residents are warm and cheerful, as well as the protective facilities are inadequate. In addition, there are significant differences in climate, cultural practices and architectural styles between the two cities, leading to poor epidemic prevention. Haikou is located in the tropics, and the annual average temperature is five times that of Harbin, a high-latitude city. Moreover, the urban culture of Haikou is a mixture of southern China and Southeast Asia, while Harbin is a mixture of Russian and northern Chinese cultural practices. In contrast to Haikou's arcade architectural style, Harbin combines traditional northern Chinese blocks with the European Baroque system. Considering their commonalities and differences, it is suggested to adopt flexible modular design in public spaces, widen the sidewalks, increase isolation points, and set up the greening belt to isolate the gathering crowd.
Study on Caster Angle and Steering Stability of Racing Car
Authors: Xie Yuntao
Published: August 2022

The topic in this article is the influence of the caster angle of the automobile. High speed and large steering is a working condition that a racing car must experience, this paper is eager to find the law of the influence of caster angle of kingpin on steering instability under high speed and large steering condition.The caster angle of the Kingpin is of great significance to the steering of a vehicle. On the one hand, it determines the stability of a vehicle when it is running in a straight line, and on the other hand, it determines the return force of the steering wheel when it is turning. In contrast, a smaller caster angle makes steering easier, but less stable at high speeds, while a larger caster angle means a slower steering with a more pronounced return to normal but better stability at high speeds, the determination of the magnitude of the caster angle is very important for the ride comfort of the vehicle.
Improvement for the Dynamics of Formula One Car Based on an Analysis of Center of Mass
Authors: Hu Zhenran , Liu Yilin , Wen Yi
Published: August 2022

Formula one has always been the culmination of motorsport, but not necessarily the end of it. As the rapid development of technology, the vehicle attains more advanced equipment and the F1 lap’s times have improved year by year, meanwhile, the safety and stability of vehicle become even more significant. The center of gravity (CG) is a crucial factor when consider the stability. Rollover could be happened when vehicle turns too fast. When vehicle turns, the weight transfer happens and the location of CG will change according to the weight transfer, therefore torque been generated in order to attain better performance of stability, it is necessary to calculate the accurate CG location. But as mentioned the location CG could change when F1 moving, it is hard to acquire its value. In this study, the location of CG will be analyzed for improving the dynamics of F1.
PCBM as The Interlayer of SnO2/Perovskite for The High Performance and Stable Perovskite Solar Cells
Authors: Xia Jianxing , Shi Yu , Jia Chunyang
Published: August 2022

Metallic oxide and the perovskite crystals easily form the surface vacancies defects at the contact interface after the perovskite solar cells (PSCs) fabrication, which usually trap the carriers of surface of semiconductor and increase the non-radiative processes, significantly against to the PSCs performance and stability. Herein, the PCBM was employed as the interlayer between SnO2 and perovskite interfaces. The results find that the introducing of PCBM will improve the open-circuit voltage (Voc) and fill factor (FF) of devices due to the surface passivation. As a result, the n-i-p PSCs based on PCBM interlayer exhibits higher efficiency of 22.05%. Furthermore, the devices also delivered a higher light stability of 96.2% of initial performance after aging 200 h aging in atmosphere without encapsulation, meanwhile the reference PSCs exhibit 88.9% of initial performance at the same condition.
Study on Optimization of Anticorrosion Technology for Valve Pit Facilities in Tahe Oilfield
Authors: Xiao Wenwen , Ge Pengli , Li Junhua , Yang Jianshun , Wang Chao , Gao Sizhe
Published: August 2022

Due to the abundant underground water source, the structure of the valve pool, the non installation of water stop flange in the crossing pipeline and other problems, the leakage disease rate of the valve pool in Tahe oilfield reaches more than 80%. If it is not treated in time, the valves, pipe fittings and other facilities will be rusted, which will affect the normal operation and daily maintenance of the valves and cause serious potential safety hazards. According to the characteristics of the valve pool in Tahe oilfield, XinJiang, the performance and construction technology of different kinds of anti-corrosion materials are studied, and the best anti-corrosion materials are optimized. Through comparative research, it is found that the multi-layer petrolatum coating technology has excellent anti-corrosion performance and simple construction technology, which can completely solve the corrosion problem of the pipe fittings inside the valve pool.
Application of functional polymer materials for marine anti-fouling
Authors: Qi Yuanqi
Published: August 2022

Marine organisms adsorb and grow on the surface of underwater facilities. This process, known as fouling, has a detrimental impact on marine shipping and development. Currently, in order to prevent marine biofouling, the most efficient and economical method is the application of antifouling coatings that synthesized by a diverse of different functional polymer materials. For this reason, this research will introduce the progress in five types of functional polymer materials, which are polymers with catechol groups, polysulfide-based polymers, polymer quaternary ammonium salts, hydrogels and silicone resin. Due to different functional groups properties as well as mechanisms of action, they have their own advantages in the application of antifouling coatings. Meanwhile, the future trend of antifouling coatings development and their application in real sea environment are prospected.
Application analysis of two flame retardant polymer materials
Authors: He Ruiyang
Published: August 2022

Flame retardants have become an integral part of the construction industry, not only to bring safety to residents in the event of fire, but also to reduce property damage. As excellent flame retardant materials, common flame retardant polymer composites mainly include two types, that is, traditional flame retardant and nano flame retardant. This research introduces the different flame retardants under the two categories and their corresponding flame retardant mechanisms in detail. And some other flame retardant polymer composites. In terms of mechanism, two important flame retardant mechanisms include dehydration and charring. In this research, the advantages and disadvantages of different flame retardant mechanisms in different polymers and their causes are introduced in detail. In addition, this research will compare the advantages and disadvantages of existing flame retardant materials and look forward to their future development trends, hoping to provide a new idea for the development of new flame retardant materials.
Research on the Control Methods Based on Liquid Level System
Authors: Zhou Wenmin
Published: August 2022

Liquid level control is a common process control in industry, and its impact on production cannot be ignored. Liquid level control systems are used in various aspects of life, such as reservoirs, cisterns, river levels, etc. Among the common liquid level control systems, the double-volume water tank is a typical controlled object, which is widely used in industrial production. The control difficulty of has also increased due to its nonlinearity and delay. PID control can achieve satisfactory results in the face of accurate mathematical models and is still widely used in society. However, PID control is less effective when dealing with nonlinear systems that are difficult to describe accurately with mathematical models. For better level control, this paper designs a double-volume tank level control system with single-loop PID control, Cascade PID Control and fuzzy PID control based on PID control theory, and compares their control effects. This paper therefore concludes that the control effect of fuzzy PID control is better than the other two controls, and through experiments, we also find that fuzzy PID has decent adaptivity. This paper provides a certain research basis for the subsequent research on PID control, which has important theoretical significance and engineering value.
Application research of MOF and its Ni-doping materials in supercapacitor
Authors: Huang Zhenhang
Published: August 2022

With the development of the technology and the automation of the modern industry, finding a new kind of energy storing device gradually occupies a significant position. The supercapacitor takes up scientists’ eyes, because of its advantages of high watt density, long servicing life and non-pollution. However, there is also some barriers blocking the way of the forward development. In this project, we use MOF-5 as the electrode material, combining with some other metal atoms to enhance its specific capacitance. Through researching, we found that using Ni as the adding atom has a markable difference. It can improve the conductivity of the electrode effectively, then enhancing the specific capacitance. Finally, we measured the data of the supercapacitor using Ni-MOF-5 as the electrode materials under different scanning speed. Then we got the specific capacitance respectively: 105  under 50 , 78 under 100 , 44  under 500 , 35  under 1000 .
Exploration of Health Management in Ship Main Power Plant
Authors: Jia Xianzhang , An Xinyuan , Jia Baozhu , Peng Cheng , Liang Tianqi
Published: August 2022

With the change of market environment, consumer demands are diversified, complex and comprehensive, this paper introduces the new concept, architecture and core technology, predicts the industry capability and demand in the main power device industry, and integrates it with digital twin, cloud service and 5G network. This paper expounds the diagnosis and prediction of ship faults in the meta-universe, constructs a meta-learning model of health management based on detection data, integrates the multi-source data information of ships, and then emphasizes the importance of meta-universe application in the health management of the ship main power device, so as to promote the digitalization of the ship industry.
Study on COVID-19 prevention and control based on the principle of sewage epidemiology
Authors: Liang Jingwen , Huang Xiner , Niu Yuanni
Published: August 2022

Through the analysis and study of the current virus level of wastewater at each site on the website, the percentage change in the past 15 days, and the percentage of wastewater samples that can detect the virus in the past 15 days, this paper establishes an evaluation model based on the distribution of sewage monitoring sampling points and a K-Means clustering model, and finally helps to add ten new sewage monitoring sampling points, and analyzes the severity of the risk of future large-scale epidemic transmission in four major regions of the United States, providing early warning and corresponding prevention and control measures for local governments. In this paper, the analytic hierarchy process is used for modeling, three keywords "population, environment and epidemic prevention" are extracted, and they are used as the criterion layer, which is then extended from the criterion layer. A total of nine three-level indicators are found as the index layer, and the scoring standard is established to judge the rationality of the distribution of sewage detection sampling points. The results show that the scores of the four major regions of the United States are more than 200, which is reasonable. In order to select ten new sampling points, K-means clustering algorithm is used to divide the data points into 10 regions based on the Euclidean distance between coordinate points. Finally, Louisiana, Nevada, West Virginia, Hawaii, South Dakota, Illinois, Georgia, Massachusetts, New Mexico and Montana are selected. In order to predict the possible large-scale epidemic situation in the four major regions of the United States, three indicators are selected: the current virus level of wastewater at each site, the percentage change data in the past 15 days and the percentage of wastewater samples that can detect the virus. The data are preprocessed by regions. The severity of the epidemic situation is estimated according to the epidemic transmission risk threshold. Finally, five suggestions are given: ① call on people to fight the epidemic together, Strengthen publicity and education on epidemic prevention and control. ②Timely respond to the complaints of local governments and epidemic prevention institutions, and implement epidemic prevention policies. ③ An emergency plan should be established to strengthen the emergency handling capacity. ④ Establish and improve the supervision mechanism to reduce the infection rate of new crown.
The role of PD-1/PD-L1 inhibitors in the treatment for non-small cell lung cancer (NSCLC)
Authors: Li Che , Xu Manyi
Published: August 2022

Non-small cell lung cancer (NSCLC) is a frequent cancer that affects people around the world. Checkpoint inhibitors are the most intensively studied treatment methods at present. Activation of PD-1/PD-L1 is accountable for suppressing the activation, proliferation, and cytotoxic secretion of T cells. By giving PD-1 /PD-L1 inhibitors, an individual's immune system can be boosted to some extent. Nivolumab, pembrolizumab, atezolizumab, and durvalumab have shown to be effective for NSCLC patients in clinical trials. The effectiveness of PD-1/PD-L1 inhibitors combining with SBRT, chemotherapy, or other checkpoint inhibitors to treat NSCLC has also been demonstrated. However, PD-1/PD-L1 inhibitors also have drawbacks, such as non-specific recognition misses, and immune-related adverse events. This article mainly discusses the role of PD-1/PD-L1 inhibitors in the treatment for NSCLC.
Application of Dienogest In the Treatment of Endometriosis
Authors: Chen Yuguang , Yang Ge , Zhao Yining
Published: August 2022

Endometriosis is a condition that exists endometrioid epithelium and/or endometrialmatrix muscular layer,usually accompanied by inflammatory processes.The new progesterone,Dienogest (DNG),has no estrogen,anti-estrogen and androgen activities,at the same time,DNGhas anti androgen activity.With a favorable safety and tolerability profile,DNG could relief pain and reduce ovarian endometriosis cysts,reduces the recurrence,meanwhile,DNG also has good effect on recurrent endometriosis.DNG mainly mediates the hypothalamus,pituitary and ovarian axis to inhibit the functions of ovarian.It can also inhibit the synthesis of estrogen metabolic enzymes,to reduce estrogen level.Through anti-inflammation and anti-angiogenesis,DNG could inhibit the development of pain,inhibite the occurrence and development of EMT lesions,which can be used as medicine for long-term management of endometriosis.Side effects such as uterine bleeding was observed,inform the patient in advance of compliance,careful long-term follow-up is required.
NSCLC Vaccines: Mechanism, Efficacy and Side Effects
Authors: Zhu Jiachen
Published: August 2022

Lung cancer is the most prevalent cancer, with more than 2.2 million lung cancer diagnosed cases and more than 1.79 million deaths worldwide in 2020, accounting for approximately 18% of the total cancer deaths, of which non-small cell lung cancer accounts for the majority. Patients with stage I-II NSCLC can be treated by surgery, but most patients have missed the period of radical surgery when they are diagnosed. Cancer vaccines as a type of immunotherapy have low side effects and strong specificity against tumor cells. Cancer vaccines can be broadly classified into three categories: peptide vaccines, cell vaccines, and nucleic acid-based vaccines. Protein/peptide vaccines continue to make up a large percentage of all vaccination types. The main target at the moment is a tumor-associated antigen. The amount of research being done on cell vaccines, particularly DC vaccines, is expanding. NSCLC nucleic acid vaccines, particularly DNA vaccines, are in short supply.
A Study on the Relationship between the 3-D Structure of Spike Proteins and Infectiousness of SARS-CoV-2 Delta Variant
Authors: Tang Ziyang
Published: August 2022

Since the outbreak of novel coronavirus pneumonia in Wuhan in 2019, the SARS-CoV-2 epidemic has become a hot topic. Over time, SARS-CoV-2 has evolved many variants. The diversity of the 3-D structure of the variant’s proteins resulted in the difference in the binding ability and infectious differences between different virus variants and human angiotensin-converting enzyme 2 (ACE2) receptors. In 2020, an evolutionary analysis of the Delta and Delta Plus variants of SARS-CoV-2 provided a three-dimensional model of the protein of the delta variant. However, it only focused on the delta variant and Delta plus variant themselves and did not compare the delta variant or delta plus variant with the original strain. It is hard to give a direct or apparent reason why the delta variant is more infectious and difficult to cure than the original strain. Therefore, this paper further compared the 3-D structures of homologous trimeric spike glycoproteins (S-proteins) and the receptor-binding domain between the SARS-COV-2 original strain and the SARS-COV-2 delta variant. By observing and analyzing the models of the above proteins in the PyMOL Molecular Graphics System, the reasons for the increase of infectivity of the delta variant can be interpreted in a direct way. This article also focuses on the data of the Indian cases from the JHU database to deeply analyze the relationship between the structure and transmission ability of the SARS-CoV-2 delta variant. Last but not least, the reproductive ability of SARS-CoV-2 can be reflected by the number of NAG (2-acetamido-2-deoxy-beta-D-glucopyranose). Through data analysis and protein structure research, we can better understand the characteristics of the binding of SARS-CoV-2 to the human receptor, thus providing a theoretical basis for accurately predicting virus variation. Through the comparative study of virus structure and infectiousness, this paper will provide a scientific basis for the relevant departments to improve epidemic prevention and improve the public's vigilance against virus variants.
The treatment of schizophrenia
Authors: Liu Xuanting
Published: August 2022

Schizophrenia is a kind of disease worldwide nowadays, and about twenty million people were found that have schizophrenia. For now, the treatment for treating schizophrenia methods includes using the psychological method, medical treatment, and Medicaid enterprise certification toolkit (MECT). The psychological method in treating schizophrenia has special advantages when the patients are not diagnosed. Pet therapy is a new way to treat patients without medicines or use in an adjuvant way. This therapy will help people get love or get warmness or become better. Research has shown that first-generation anti-schizophrenia medicine (FGAs) and second-generation anti-schizophrenia medicines (SGAs) have different effects. For example, CPZ in FGAs can help patients think normally and reduce the possibility of nervousness, but CPZ also has certain side effects, such as causing patients to have skin pigmentation. SGAs are very effective in treating schizophrenia and can also reduce the risk of side effects. SGAs have been replaced by FGAs in large populations and are also the first choice for researchers to use. Clozapine is a classic SGA drug. Studies have shown that it is safe for patients taking clozapine long-term. However, additionally, clozapine has been shown to cause a number of blood problems, as well as cardiac arrhythmias, such as QT prolongation. For now, the psychological method should be the first choice for the patient who has not been diagnosed. Some new treatment methods are still in progress, like MECT and new medicines for more target acceptors. This paper review briefly the treatment of schizophrenia.
The Intervention and treatment of the Poliomyelitis
Authors: Liu Xiaoyi , Yao Tianchen
Published: August 2022

Polio comes from a wild polio-virus that infects children and has a high mortality rate.  Once infected, there is no cure. So in the face of polio, more attention is paid to prevention measures and the follow-up treatment of survivors of polio disease. It covers the background to polio, the international response, and what has been achieved over the years in polio control. Polio prevention is divided into a vaccine component and daily protection, with the Inactivated polio vaccine (IPV) and Oral polio vaccine (OPV), OPV being an oral vaccine and IPV requiring a medical professional to administer it. The two are most effective when used together. Next is the daily protection, such as isolating close contacts and paying attention to human hygiene, etc. For the follow-up treatment of polio survivors that is, post-poliomyelitis patients. A variety of methods are used in this treatment, and the final clinical results show that non-pharmacologic treatment is more conducive to improving patients' lives and active treatment.
The current mechanism and treatment methods for depression
Authors: Ye Yutong
Published: August 2022

Depression is a very common illness that negatively affects people's lives, mental states and families. This paper explains the causes of depression from both psychological and biological perspectives, finding that it is related to negative psychology and drugs, gender, genetics, brain chemistry, and even brain structure. At the same time, this paper analyzed the differences, effects and applicability of psychological, medical and physical therapy, and found that mild depression usually does not need medical intervention; Moderate and severe depression is usually treated with a combination of psychotherapy and medication; Less sensitive people can be treated with more aggressive brain stimulation.
Characteristics And Comparison of Tossy and Rockwood Classifications for Acromioclavicular Joint Separations
Authors: Zhang Jingwen
Published: August 2022

Acromioclavicular joint (AC joint) is one of the four articulations that make up the shoulder joint. Injuries related to the shoulder joint often damage the AC joint. Since AC joint separation is usually caused by external force applied to the shoulder, it is one of the most familiar shoulder injuries in sports, especially sports with body contact such as ice hockey, football, and basketball. As the force that causes injury varies, there are different grades of severity of the AC joint separation. This study focuses on two main classifications (Tossy classification and Rockwood classification) of the severity of the AC joint separation and discusses the corresponding treatments as well as the criticisms of each classification. Tossy three-degree classification is straightforward that could be categorized quickly after diagnosis. Grade 1 requires the use of a well-designed sling, Grade 2 needs a specific treatment plan, and Grade 3 requires open surgeries. Rockwood's six-type classification is more detailed than the three-degree classification and represents the complicated pathophysiology. Types I and II are recommended for non-operative treatments, Type III should adopt non-operative treatment firstly, and then the operative management. Types IV, V, and VI need surgical treatments.
Unleashing Anti-Tumor Activity of Natural Killer Cells Via Modulation of Immune Checkpoints Receptors and Molecules
Authors: Fang Yifei
Published: August 2022

As vital innate lymphocytes, natural killer (NK) cells suppress cancer progression chiefly by inducing cell lysis and secreting pro-inflammatory cytokines. NK cell activation relies on the balance between inhibitory and stimulating signals mediated by a wide range of surface receptors. Specific receptors initiate intracellular signaling pathways, which are negatively regulated by specific checkpoint molecules. Synergistic activation is controlled by Cbl proteins and GSK-3β, while the downstream signaling pathways induced by ITIM-bearing receptors are regulated by SHP-1. These intracellular NK checkpoints are attractive targets for immune checkpoint blockade therapies, but not enough attention has been given. Hence, this paper discusses the major signaling pathways regulated by the intracellular checkpoints and their potential clinical application. The current progress in the investigation of NK checkpoint receptors is also summarized. This paper aims to promote the development of novel immunotherapies that optimize the tumor-suppressive activity of NK cells while suppressing tumor immunological evasion.
The Clinic trials of Human Immunodeficiency Virus
Authors: Li Junhong
Published: August 2022

This review paper looks for future improvement for HIV. It is obvious that HIV has become a pandemic disease and causes serious problems to human life quality, social stability and public health. However, there are still a lot people get infected by HIV and the mortality of HIV patients has decreased compared with the time that the disease was discovered. By understanding the virus structure and the mechanisms when the pathogen enters the body, humans can find ways to solve AIDS infection in these ways, from the source of the pathogen, the transmission path, and patients infected by HIV. Second, by analyzing two successful cases of HIV cured patients and the failure cases, humans find out that not everybody is suitable for the same treatments as the two successful cased did. Although, nowadays, scientists are working on HIV vaccines, the process is very slow as there are still a lot of mysteries in human immunodeficiency virus and HIV vaccines. Few types of vaccines were undergoing clinical trials. Humans still have a long way to go to overcome HIV, but as more and more attention are paid to HIV patients and the projects which are trying to overcome it, HIV patients’ life quality had improved a lot and their life cycles are prolonged.
Research and Treatment Progress of Capmatinib in Hepatocellular Carcinoma
Authors: Xin Mengqi
Published: August 2022

Hepatocellular carcinoma (HCC) cases account for the vast majority of liver cancer with high mortality. There is no particular therapy for HCC, and it has been claimed that only around 25% of individuals with HCC are candidates for curative surgery. The only drug approved FDA for HCC is Sorafenib, however it is prone to drug resistance. Abnormal c-met activity is linked to Tumorigenesis and tumor metastasis, implying that inhibiting relevant pathway might be therapeutic. HGF/c-Met pathway is related HCC exacerbation and metastasis, abnormal met signaling leads to activated downstream pathways and causes tumorigenesis. also, the HGF/c-Met induces the VEGF pathway to enhance tumor angiogenesis. Met is becoming a key target in HCC treatment, especially in advanced patients. As a small molecure met inhibitor, Capmatinib has high sensitivity of Met receptor, it can be absorbed rapidly, with good pharmacokinetic characteristics. It has good antitumor activity in clinical efficacy, well toleranced and with slight side effects. In addition, it is irrelevant to food which means patients have the same concentration of capmatinib in plasma regardless of their eating habits, which will be an effective and safe treatment strategy for HCC. Application of Capmatinib as HCC target treatment remains popular in HCC research, and clinical trials designed in diverse dimensions are ongoing to study the benefits of capmatinib.
Characteristics and Vaccines: Five Variants of Concern of SARS-CoV-2
Authors: Xu Mengtong
Published: August 2022

Since the detection of the novel coronavirus in 2019, all countries in the world have been affected, the economy has declined, and people's health has been greatly threatened. Although with the in-depth study of the virus, several vaccines have been developed and put into use. However, due to the characteristics of the virus itself, its mutation speed is very fast, resulting in the delay of the vaccine relative to the virus. This article outlines and summarizes the evolutionary route and each important mutation point of the mutant strains, as well as their impact on the characteristics and vaccine development, so as to find out or predict the variation law of novel coronavirus or the trend of its transmissibility and pathogenicity, and provide new ideas on how to develop effective vaccines and how people finally deal with sars-cov-2.
Drug discovery of PD-L1 inhibitor Atezolizumab
Authors: Guo Xinying , Sheng Xinyi
Published: August 2022

Immunotherapy, especially immune checkpoint inhibitors have made a tremendous breakthrough in NSCLC management. Over last decades, ICIs targeting the PD-1, PD-L1 and CTLA-4 have exhibited promising antitumor efficacy and durable response including NSCLC patients with advanced or refractory, metastatic disease. We will provide an overview of mechanism of cancer development and how current available ICIs can be employed to improve patients’ outcome. This review also summarized the discovery process of atezolizumab which led to final FDA approval for its indication. Our major focus is on the significant survival benefit achieved by atezolizumab and taking into consideration of its advantages and disadvantages when we applied it into clinical setting. We hope to help patients and clinicians to better understand the mechanisms, clinical progress and future research direction of NSCLC atezolizumab in decision making.
The discovery of Fluroxene in depression treatment
Authors: Yang Jiaying
Published: August 2022

Depression, particularly major depressive disorder (MDD), has become the world's most frequent mental illness. As the demand for antidepressant medication expanded, monoamine-oxidase inhibitors (MAOIs) were explored first, followed by selective serotonin reuptake inhibitors (SSRIs). One of the most widely recommended SSRIs for the treatment of major depression is fluoxetine (MDD). Fluoxetine has recently been in marketing and therapy, and it has already gone through multiple stages. This document provides an overview of fluoxetine, including its mechanism of action and typical adverse effects. Furthermore, the purpose of this work is to suggest the discovery method (phases I, II, and III), as well as to finish the processes involving sample size, type, and designation. The comparison experiments were taken to suggest how effective the fluoxetine was with the addition of other pharmacies. This review focused on the discovery of Fluroxene in depression treatment.
HUBUNGAN POLA ASUH ORANG TUA TERHADAP PRESTASI BELAJAR SISWA KELAS IV DAN V DI SD N 3 CANDIKUNING
Authors: Gede Yenny Apriani Desak
Published: August 2022

The Relationship Between Parenting Style And Learning Achievement Of Fourth And Fifth Grade Students At SD N 3 Candikuning

Desak Gede Yenny Apriani1, Desak Made Firsia Sastra Putri2, Wira Sukanada3

1The Study Program Of Nursing Science Nurses, 2The Health College Of Advaita Medika Tabanan

email : yennyapriani2004@gmail.com

ABSTRACT

 

Background: Children's learning achievement cannot be separated from the role of parents, because parenting provided by parents can affect children's learning achievement. Children who get good parenting can increase their learning achievement, while poor parenting will result in a decrease in learning achievement in children.

 

Objective: This research aims to determine the relationship between parenting styles and student achievement in grades IV and V at SD N 3 Candikuning.

Methods: This research is a descriptive analytic research with a cross sectional approach. The sampling technique is Total Sampling. The research subjects were 40 students in grades 4 and 5 of Candikuning State Elementary School 3. The independent variables include parenting style and the dependent variable is learning achievement. Data were analyzed using Spearman's rho test.

 

Results: The results of the measurement of parenting patterns of fourth and fifth graders at SD N 3 Candikuning obtained data on the majority of democratic parenting as many as 23 people with a percentage of 57.5%. The category of student achievement in grades IV and V at SD N 3 Candikuning mostly good learning achievements as many as 18 people with a percentage of 45%.. and there is a relationship between parenting styles and learning achievement of fourth and fifth grade students at SD N 3 Candikuning which was tested by Sperman Rho in getting a significant value of p = 0.033 Conclusion: Based on the results of the study, it can be concluded that there is a relationship between parenting styles and learning outcomes for fourth and fifth grade students at SD N 3 Candikuning, therefore parents are expected to provide extra care and education at home in order to help improve learning achievement from child.

Keywords: Parenting Pattern, Learning Achievement.
TINGKAT AKTIVITAS FISIK PADA MAHASISWA SARJANA KEPERAWATAN DI MASA PANDEMI COVID-19
Authors: Dewi Kadek Wiwien Pradnyaswari
Published: August 2022

Background: Healthy living is something that every individual desires. It can be realized by doing physical activity. COVID-19 pandemic has resulted the outside activities restrictions, it could interfere with a physical activity.

Objective: To determine the level pf physical activity among students of bachelor of nursing program at Institute of Technology and Health Bali during Covid-19 Pandemic.

Method: This study employed descriptive design with cross sectional approach. There were 225 students of bachelor of nursing program at Institute of Technology and Health Bali selected as sample of the study which were selected by using probability sampling technique and stratified random sampling type. The data were collected by using Global Physical Activity Questionnaire (GPAQ).

Results: From 225 respondents there were 127 respondents (49.8%) had low physical activity, there were 88 respondents (34.5%) had moderate physical activity, there were 40 respondents (15.7%) had high physical activity. The finding showed that the majority of respondents had low physical activity.

Conclusion: The majority of respondents had low physical activity.
TINGKAT KEPUASAN MASYARAKAT TERHADAP PELAYANAN VAKSIN COVID-19 DI DESA BELANTIH KECAMATAN KINTAMANI
Authors: Ati Ni Wayan Juni
Published: August 2022

Background. The Covid-19 Vaccine Service is the latest breakthrough in handling the Covid-19 Pandemic. Vaccination must be carried out optimally in providing services because client satisfaction is the primary indicator of health services' success. The purpose of this study was to identify the level of community satisfaction with the Covid-19 Vaccine service in Belantih Village, Kintamani District. Method. This study employed descriptive quantitative research with a cross-sectional approach. The population was the people of Belantih Village who had received the Covid-19 vaccine, a total of 1655 people. The number of samples was 343 respondents through probability sampling technique with the stratified random sampling, then in each Banjar using the Simple Random Sampling method. The data were collected using a questionnaire made by the researcher and analyzed using descriptive statistics. Results. Findings indicated that the percentage level of community satisfaction with the Covid-19 Vaccine service in Belantih Village, Kintamani District,  was in the satisfied category (93.3% of respondents). Based on the percentage results for each satisfaction characteristic, the respondents were satisfied in all characteristics, Tangibles (54.2%), Reliability (54.5%),  Responsiveness (55.4%), Assurance (65.3%), and Empathy (60.6%). Conclusion. Most respondents (93.3%) said they were satisfied with the Covid-19 Vaccine service in Belantih Village, Kintamani District.
RIWAYAT PEMBERIAN ASI EKSKLUSIF HUBUNGAN RIWAYAT PEMBERIAN ASI EKSKLUSIF DENGAN KEJADIAN STUNTING PADA BALITA DI DESA YANGAPI TAHUN 2021
Authors: Primadewi Kadek
Published: August 2022

Latar Belakang: Pertumbuhan seorang balita sangat ditentukan oleh asupan gizi yang didapatkan sejak dari dalam kandungan. Balita merupakan kelompok umur yang paling rentan mengalami kekurangan gizi, gizi buruk maupun stunting. Jika asupan gizi yang didapatkan kurang maka pertumbuhan yang terjadi tidak akan sempurna. Periode 1000 hari pertama kehidupan merupakan hal yang sangat penting dan berpengaruh bagi pertumbuhan fisik, kecerdasan dan produktivitas, jika periode ini tidak didapatkan dengan baik maka dapat berdampak buruk bagi seorang balita seperti stunting.

Tujuan: Untuk mengidentifikasi hubungan antara riwayat pemberian ASI eksklusif dengan kejadian stunting pada balita di Desa Yangapi.

Metode: Penelitian ini menggunakan disain case control dan metode observasional analitik. Penelitian ini dilakulan di Desa Yangapi dengan jumlah sampel 137 balita usia 1-5 tahun, yang terdiri dari 68 balita yang menderita stunting (kasus) dan 69 balita yang tidak menderita stunting (kontrol). Variabel dependen penelitian ini adalah kejadian stunting sedangkan variabel independennya adalah pemberian ASI Eksklusif.

Hasil: ada hubungan riwayat ASI ekslusif dengan kejadian stunting pada balita di Desa Yangapi dengan nilai chi square sebesar 25,475, nilai p value sebesar 0,000 < 0,05 dan nilai OR sebesar 6,349.

Simpulan: Terdapat hubungan antara riwayat pemberian ASI Eksklusif dengan kejadian stunting di Desa Yangapi tahun 2021.
Eligibility Of Education And The Important Role Of Green Economy In Reducing Poverty Level
Authors:   STIE Jaya Negara Tamansiswa Malang, Indonesia, Budhi Irawan Cahya , Harnani Sri
Published: August 2022

This study investigates Green Economic, Education and Poverty. This study investigates data at the start point year of 2000 to 2020 to generate "autoregressive vectors" that can be utilize for determine relationship among the variables. This model is to analyze between Green Economic, Education and Poverty expenditure in Indonesia. We found that the Green Economy is very important in life, just like education, weak education is stated to increase the number of poverty, just as education has a positive impact on the green economy, from here we can see the importance of education for life, the better the education, the better also a green economy and education can reduce poverty.