bluuebunny/crossref_metadata_2025 huggingface dataset:
Platform Cooperativism in Italy and in Europe
Authors: Martinelli Francesca , Bozzoni Samuele , Caroli Simone , Tamascelli Francesca , Guerini Giuseppe
Published: February 2022

This research investigates some cases of cooperative platforms in the field of workerowned cooperation and consumer cooperation and explores the effects of the merger of platform technology with cooperation. The research focuses on the main consequences of this merger on the organizational model and the engagement level of individuals and studies the change of attitudes of providers and consumers when they are engaged in a cooperative project. The argument is that a cooperative platform can offer solutions and answers to both platform workers’ needs and problems of modern consumption by allowing both providers and consumers to join the entrepreneurial project, share resources – and, in specific cases, earnings – in an equal way, and be part of a community. Against the outsourcing and dispersive models of a classical digital platform, such as Deliveroo, Uber or Airbnb, where providers and consumers are separated and isolated, a cooperative platform enables the propensity of providers and consumers to engage in collective actions and become the protagonist of the platform activity. In this way, the organizational form of a cooperative platform is both an alternative to classical digital platforms and an evolution of traditional cooperative models.
The governance of State-owned Enterprises (SOEs) operating under monopoly situation
Authors: Bauby Pierre
Published: February 2022

This paper aims to treat specific issues about the governance of State-owned Enterprises (SOEs) operating under monopoly situations, in particular the link between regulation, evaluation, control and modernisation of such enterprises. The survey of the literature reveals a lot of studies on some of these topics, but very few on the link between them and such SOEs’. The paper addresses in particular the asymmetries of information and expertise between public authorities and SOEs; the strategic role of the State in the EU context, rights and duties of public authorities; how to minimize asymmetries of information between monopoly situations and public authorities; what type of regulatory bodies can be set up; how to implement evaluation both of “regulation” and of the economic and social efficiency of each State-owned Enterprise (SOE); why and how to involve stakeholders’ participation.
Corporate social responsibility in non-profit organizations
Authors: Plaisance Guillaume
Published: February 2022

The concept of corporate social responsibility (CSR) in nonprofit organizations (NPOs) is a challenge for the literature and for the organizations themselves. The concept is often confused with social responsibility or sustainability. The pleonasm between CSR and the mission, values and nature of NPOs also raises questions. Finally, the relevance of the concept in its current state to NPOs calls into question, because of the “corporate” terminology.

Design/methodology/approach: Based on a literature review, this article proposes to respond to these different gaps thanks to an analysis of the definitions, the theories, measurement methods and content of research dedicated to CSR, social responsibility and sustainability.

Findings: The research underlines the triple relevance of the concept of CSR in NPOs. Its relevance to the other two concepts, its strategic importance and the interest of differentiation from for-profit organizations.

Originality: This article proposes a literature review on CSR in NPOs, a subject that is still emerging in the literature but which nevertheless needs to be addressed in the current context of multiple crises.
Physiological properties of cells under microgravity conditions
Authors: Сергеева Е.А. , Соколовская А.А. , Кубатиев А.А.
Published: February 2022

Гравитация оказывает сильное влияние на физиологию человека, включая атрофию мышц, снижение плотности костей, дисбаланс иммунной и сердечно-сосудистой систем, эндокринные нарушения. Эти физиологические изменения представляют собой серьёзные препятствия для длительных космических путешествий. Механизмы нарушения физиологии человека в условиях микрогравитации остаются неизвестными, что порождает многочисленные открытые вопросы, касающиеся адаптивных изменений, которые происходят на клеточном и молекулярном уровне. Использование наземных средств моделирования микрогравитации позволяет получить данные о влиянии невесомости на биологию разных клеток. В этом обзоре рассматриваются последние данные о влиянии моделированной микрогравитации на клеточном уровне: на адгезию, морфологию, механочувствительность и апоптоз. Таким образом, исследования, проводимые в условиях микрогравитации, могут расширить наши знания, о биологических механизмах, лежащих в основе клеточной физиологии и патофизиологии человека.

Gravity has a profound influence on human physiology, including muscle wasting, decreased bone density, immune and cardiovascular functions, and endocrine disruption. These physiological changes represent major obstacles to long-term space missions. The mechanisms by which human physiology is disrupted in microgravity remain unknown, rendering numerous open questions regarding the adaptive changes that occur at the cellular and molecular level in response to microgravity. The use of ground-based facilities to simulate microgravity provides a better understanding of the effect of weightlessness on cells. This review will give recent insights into the impact of simulated microgravity on cells and how this technology may improve our understanding of the effects of space on human physiology and pathophysiology.
On solvability of nonlocal boundary value problem for a differential equation of composite type
Authors: Тарасова Г.И.
Published: February 2022

Изучается разрешимость в анизотропных пространствах Соболева нелокальных по временной переменной задач для дифференциальных уравнений составного (соболевского) типа$$u_{tt}+\left(\alpha\frac{\partial}{\partial t}+\beta\right)\Delta u+\gamma u=f(x,t),$$где $x = (x_1,\ldots , x_n) \in\Omega\subset R^n$, $t\in(0, T),$ $0 < T < +\infty$, $\alpha, \beta, \gamma$ - заданные действительные числа, $f(x, t)$ - заданная функция. Доказываются теоремы существования и несуществования, единственности и неединственности регулярных решений (решений, имеющих все обобщенные по С. Л. Соболеву производные, входящие в соответствующее уравнение).
Assessment of the effectiveness of management of innovative development institutions at the meso level
Authors: Abutalipova Yu. A.
Published: February 2022

The purpose of the study is to identify the specifics of the management of technological platforms, in particular, in the light and textile industries, and to evaluate the effectiveness of innovation development institutions' functioning at the meso level. The methodological basis of the study was modern scientific approaches to aevaluating the effectiveness of innovation development institutions' functioning, evaluating the effectiveness of technology platform management systems: descriptions, structural-functional and system analysis, cause-and-effect relationships, cluster and factor analysis. To achieve this goal, a simulation of evaluating the effectiveness of technological platforms has been carried out, because of which 3 types of Russian platforms were revealed, the management of the development of which requires a differentiated approach. Since the technological platform “Textile and Light Industry” occupies a leading position in the rating of Russian technological platforms, the industry development's dynamics, allowing to evaluate the impact of communication platform functioning on Russian industrial complex development, was studied. To assess the effectiveness, it was planned to form a comprehensive indicator of of light industry development based on the results of factor analysis (by the method of principal components). It has concluded that the creation and development of a technological digital environment contribute to the effective interaction between various sectors of the economy and market entities, which is based on regulatory and legal regulation, ensuring information security, developing innovative infrastructure, providing highly qualified personnel in the industry.
Functional modeling of the process of bringing innovative products to the market in mechanical engineering
Authors: Shinkevich A. I. , Shumkin A. V.
Published: February 2022

The research is aimed at building a functional model ofmarket launch process of innovative mechanical engineering products. The subject of the study was the innovative process of a machine-building enterprise. The research methodology includes a comparative analysis and analysis of dynamic series, the concept of DCOR modeling, and IDEF0 methodology. As a result of the study, the patterns of innovative development of machine-building industries in Russia have revealed. The decomposition of the DCOR model of market launch process of innovative products adapted to the machine-building industry has proposed. The levers of successful market launch of innovative products have offered. A functional model of market launch process of innovative mechanical engineering products has developed. The model has formalised in the IDEF0 notation, which in general can contribute to the opening and use of a “window of opportunity” for the implementation of breakthrough innovation. The formulated conclusions contribute to the development of the theory of innovation in the context of machine-building industry and can be applied in planning and forecasting the innovative development of industrial enterprises.
Features of a woman᾿s style company management
Authors: Gololobova T. M.
Published: February 2022

Gender studies of work effectiveness of male and female have being conducted for a long time. However, with the trend of the spread of equality, they become particularly relevant. It is impossible to say with certainty which manager is more effective. Both a woman and a man can be equally effective in any position. At the same time, it cannot be denied that there are significant differences between the male and female management style. They can be considered in a certain approximation, since there are always exceptions to the rules. The article examines the advantages and disadvantages of women’s management style, provides a typology of women managers, a criterion analysis of female and male management styles. And recommendations are also given on what points a female manager needs to work on in order to be more effective at work.
The folic acid metabolite 7,8-dihydrofolate can decrease the interactions of ACE2 with the Wild type, but not with the Beta and Delta SARS-CoV-2 variants: A silico study.
Authors: Acosta-Elias J. Jesus , Saavedra-Alanis Victor M , Monzón-Tapia Cristina , Martínez-Rodríguez Ricardo E , Guzmán-Hernández Maria Luisa , Arjona-Villicaña P. David , Espinosa-Tanguma Ricardo
Published: February 2022

There is evidence that high levels of folic acid in human plasma may prevent SARS-CoV-2 infections or reduce its symptoms. However, the mechanisms that enable this inhibition are still unknown. This article proves, through molecular dynamics simulation, that folic acid metabolite 7,8-dihydrofolate (DHF) has high affinity to bind as ligands to the angiotensin-converting enzyme 2 (ACE2), and when this complex has been formed, the Wild type SARS-CoV-2 virus cannot bind to the ACE2 receptor, possibly inhibiting infection to the host cell. In contrast, the Beta and Delta variants of this same virus can join the ACE2 with high affinity even with the presence of DHF. This results lead to the conclusion that DHF may inhibit infection from the Wild type SARS-CoV-2 virus, but not its Beta and Delta variants. These results could explain the almost double increase in severe cases of COVID-19 due to the delta variant in pregnant women compared to the Wild type SARS-CoV-2.
Phenanthroimidazole-based Covalent Organic Frameworks with Enhanced Activity for the Photocatalytic Hydrogen Evolution Reaction
Authors: Liu Cong-xue , Pan Dong-Lai , Seo Younggyu , Park Seungjae , Kan Jing-Lan , Choi Wonyong , Lee Eunsung
Published: February 2022

The rational design of organic semiconductors based on crystalline covalent organic frameworks (COFs) as efficient photocatalysts is highly desirable. In this study, the first example of phenanthroimidazole-based COFs is reported: PImCOF1 with an imine linkage and PIm-COF2 with a β-ketoenamine-linkage. Both COF materials showed substantial optical properties. The average hydrogen evolution rate was 7417.5 μmolg-1h-1 for PIm-COF2, which was 20 times higher than that of PIm-COF1 (358.5 μmolg-1h-1). This can be attributed to the strong donor-acceptor effect of PIm-COF2 and the continuous separation and transfer of the photoexcited electron-hole pair from the phenanthro[9,10-d]imidazole moiety.
AIMSim: An Accessible Cheminformatics Platform for Similarity Operations on Chemicals Datasets
Authors: Bhattacharjee Himaghna , Burns Jackson , Vlachos Dionisios
Published: February 2022

The recent advances in deep learning, generative modeling, and statistical learning have ushered in a renewed interest in traditional cheminformatics tools and methods. Quantifying molecular similarity is essential in molecular generative modeling, exploratory molecular synthesis campaigns, and drug-discovery applications to assess how new molecules differ from existing ones. Most tools target advanced users and lack general implementations accessible to the larger community. In this work, we introduce Artificial Intelligence Molecular Similarity (AIMSim), an accessible cheminformatics platform for performing similarity operations on collections of molecules (molecular datasets). AIMSim provides a unified platform to perform similarity-based tasks on molecular datasets, such as diversity quantification, outlier and novelty analysis, clustering, and inter-molecular comparisons. AIMSim implements all major binary similarity metrics and molecular fingerprints and is provided as a Python package that includes support for command-line use as well as a fully functional Graphical User Interface for code-free utilization.
Peculiarities of blood coagulation disorders in patients with COVID-19
Authors: Evtugina Natalia G. , Sannikova Svetlana S. , Peshkova Alina D. , Safiullina Svetlana I. , Andrianova Izabella A. , Tarasova Gulzada R. , Khabirova Alina I. , Rumyantsev Aleksandr G. , Ataullakhanov Fazoil I. , Litvinov Rustem I.
Published: February 2022

Aim. To study the relationship of hemostatic disorders with inflammation and estimate their role in the course and outcomes of COVID-19.
Materials and methods. We examined 215 consecutive patients with moderate and severe forms of acute COVID-19. The patients were on anticoagulants and immunosuppressive drugs. Hemostasis was assessed using the thrombodynamics assay, thromboelastography, fibrinogen and D-dimer levels, prothrombin time, and soluble fibrin-monomer complexes (ethanol gelation test). The hemostatic parameters were correlated with hematological and biochemical tests, including markers of inflammation (C-reactive protein, interleukins 6 and 8), as well as with the disease severity and outcomes.
Results. Laboratory signs of coagulopathy were revealed in the vast majority of the cases. Despite the use of low-molecular-weight heparins in the prophylactic and therapeutic doses, coagulopathy in COVID-19 manifested predominantly as hypercoagulability that correlated directly with the systemic inflammation and metabolic changes due to liver and kidney dysfunction. A direct relationship was found between the grade of coagulopathy and the severity of COVID-19, including comorbidities and the mortality. The chronometric hypocoagulability observed in about 1/4 cases was associated with a high level of C-reactive protein, which may decelerate coagulation in vitro and thereby mask the true inflammatory thrombophilia. Persistent hyperfibrinogenemia and high D-dimer in the absence of consumption coagulopathy suggest the predominance of local and/or regional microthrombosis over disseminated intravascular coagulation.
Conclusion. The results obtained substantiate the need for laboratory monitoring of hemostasis and active prophylaxis and treatment of thrombotic complications in COVID-19.
Results of immunoprophylaxis of HIV-infected patients with 13-valent conjugated pneumococcal vaccine
Authors: Zhestkov Alexander V. , Zolotov Maxim O. , Lyamin Artem V. , Borisova Olga V. , Chernova Oksana E. , Zheleznova Elena A. , Ismatullin Danir D.
Published: February 2022

Aim. To assess changes in the composition of the microflora of the upper respiratory tract and indicators of cellular immunity 1 year after the administration of 13-valent conjugated pneumococcal vaccine (PCV13) in adult HIV-infected patients.
Materials and methods. Were recruited 100 participants of both sexes (50% male and 50% female). All patients underwent microbiological and immunological (determination of the level of CD3+, CD3+CD4+, CD3+CD8+, CD19+, CD45RO+ peripheral blood lymphocytes) examinations before vaccine administration and after 12 months.
Results. Immunization with PCV13 leads to a statistically significant decrease in the carriage of Streptococcus pneumoniae 1 year after vaccination (p=0.012). After 1 year after the administration of PCV13, the patients showed a statistically significant increase in the total number of T-lymphocytes, T-helpers, and cytotoxic T-lymphocytes in comparison with pre-vaccination levels. A statistically significant increase in the level of CD45RO+ lymphocytes was found 1 year after the administration of PCV13 (p0.0001). S. pneumoniae was found on the mucous membrane of the posterior pharyngeal wall in 16% of the participants, indicating its high prevalence in HIV-infected patients. Also, representatives of enterobacteria and Candida spp. were found in smears. (22 and 15% of participants, respectively). One year after the vaccine administration, pneumococcus was isolated from 5 participants, which is statistically significantly lower than before immunization (p=0.012). After the introduction of PCV13, there is a statistically significant increase in the total number of T-lymphocytes, T-helpers and cytotoxic T-lymphocytes 1 year after immunization. However, there is no statistically significant increase in the B-lymphocyte population. In addition, PCV13 leads to the formation of immunological memory cells in HIV-infected patients.
Conclusion. Thus, immunoprophylaxis with PCV13 in adult HIV-infected patients leads to a decrease in the carriage of S. pneumoniae, and also promotes the stimulation of the T-cell link of the immune system and stimulates the formation of immunological memory cells.
Unspecified encephalitis in HIV-infected patients: clinical and postmortem evaluation
Authors: Voznesenskiy Sergey L. , Shakhgildyan Vasiliy I. , Petrova Elena V. , Kozhevnikova Galina M. , Ermak Tatiana N. , Tichkevich Oleg A. , Samotolkina Elena S. , Soboleva Zinaida A. , Emerole Karl C
Published: February 2022

Background. The search for an aetiology of central nervous system (CNS) lesions In HIV patients can be extremely challenging.
Aim. To establish the nature and character of CNS lesion according to the data of pathological examination of deceased HIV-patients who had an antemortem clinical diagnosis of unspecified encephalitis.
Materials and methods. We analysed clinical and laboratory data of 225 HIV-patients admitted to the ICU at the Infectious Clinical Hospital №2 (Moscow, 2018). The principal diagnosis was unspecified encephalitis characterized by cerebral oedema. Had died 183 (67.9%) patients. We conducted pathological examination in 43 (23.5%).
Results. CNS lesions occurred in 331 patients (58.8% of 563 ICU). The antemortem diagnosis established were as follows: 12.1% toxoplasmosis; 6.6% HIV-encephalitis; 5.1% CNS lymphoma; 3.6% cryptococcal meningoencephalitis; 3.0% cytomegaloviral diseases; 2.1% progressive multifocal leukoencephalopathy. The cause of the pathology remained unidentified in 225 patients (68% with CNS lesions). Majority of patients were ART-naive. Post-mortem verification was conducted in 29 (67.4%) deceased patients, of which HIV-encephalitis 34.5%, toxoplasmosis 10.3%, progressive multifocal leukoencephalopathy 3.4%. The nature of brain damage in the remaining 20.7% cases was not established even after post-mortem investigation. Productive lepto-meningitis 8 (27.6%), indicating a prolonged duration of the inflammatory process. In the brain 48.1% patients with subacute and productive changes, had a pre-hospital time of more than 30 days, in contrast to 11.1% of patients who had acute pathological processes in the CNS (p0.05). Autopsy didnt reveal any inflammatory changes in the brain in 14 (32.6%) patients, though cerebral oedema 93.3%, haemorrhagic syndrome 60% cases.
Conclusion. Accurate retrospective identification of the aetiology of CNS lesions combined with assessing in vivo characterisation of the pathological process plays an essential role in subsequent formation of diagnostic approaches in pathologies of the CNS in HIV-patients.
Pharmacoepidemiological research of COVID-19 in the Russian Federation EGIDA-2020
Authors: Pshenichnaya Natalia Yu. , Kareva Elena N. , Leneva Irina A. , Bulgakova Vilya A. , Kravchenko Irina E. , Nikolaeva Irina V. , Grekova Antonina I. , Ivanova Antonina P. , Puzyreva Larisa V. , Khasanova Guzel M. , Orlova Svetlana N. , Tikhonova Elena P. , Petrov Vladimir A. , Malinin Oleg V. , Kolaeva Natalia V. , Volchkova Elena V. , Kanshina Nina N. , Chulanov Vladimir P.
Published: February 2022

Aim. An analysis of coronavirus infection in Russia and evaluation of different AVT regimens effectiveness.
Materials and methods. The study involved a retrospective analysis of 1082 patient records with laboratory-confirmed COVID-19 in 17 regions of Russia. The number of men and women was equal, mean age 48.718.1 (median 50). Patients with moderate COVID-19 (85%) versus mild COVID-19 (15%) were characterized by higher age (median 54 vs 21 years; p0.001), higher body mass index (27.8 vs 23.4; p0.001), prevalence of chronic diseases (75.3% vs 8.5%; p0.001), including circulatory system diseases (37.8%). Moderate COVID-19 characterized higher intoxication (10.86.1 vs 4.22.7 days; p0.001) and catarrhal symptoms duration (10.25.4 vs 6.14.1 days; p0.001).
Results. During hospitalization 92% of the patients received AVT, 77% antibiotics, and 16% corticosteroids. Umifenovir therapy resulted in a significant reduction of intoxication (8.75.5 vs 11.75.5 days; p0.001) and catarrhal symptoms duration (8.85.1 vs 12.04.9 days; p0.001) compared to the group without AVT. The usage of INF reduced intoxication symptoms compared with the group without AVT (8.97.5 vs 11.75.5; p0.05). Therapy with hydroxychloroquine, imidazolylethanamide pentandioic acid, and lopinavir + ritonavir combination did not affect the course of COVID-19. Most of adverse reactions were related to antibiotics.
Conclusion. Umifenovir therapy and inclusion of interferon in AVT regimens was associated improvement in the clinical manifestation of the disease among patients.
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures
Authors: Guo Wenrui , Porter Linsey M , Crozier Thomas WM , Coates Matthew , Jha Akhilesh , McKie Mikel , Nathan James A , Lehner Paul J , Greenwood Edward JD , McCaughan Frank
Published: February 2022

Background: There are limited effective prophylactic/early treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Viral entry requires spike protein binding to the angiotensin-converting enzyme-2 receptor and cleavage by transmembrane serine protease 2 (TMPRSS2), a cell surface serine protease. Targeting of TMPRSS2 by either androgen blockade or direct inhibition is in clinical trials in early SARS-CoV-2 infection. Methods: We used differentiated primary human airway epithelial cells at the air–liquid interface to test the impact of targeting TMPRSS2 on the prevention of SARS-CoV-2 infection. Results: We first modelled the systemic delivery of compounds. Enzalutamide, an oral androgen receptor antagonist, had no impact on SARS-CoV-2 infection. By contrast, camostat mesylate, an orally available serine protease inhibitor, blocked SARS-CoV-2 entry. However, oral camostat is rapidly metabolised in the circulation, with poor airway bioavailability. We therefore modelled local airway administration by applying camostat to the apical surface of differentiated airway cultures. We demonstrated that a brief exposure to topical camostat effectively restricts SARS-CoV-2 infection. Conclusion: These experiments demonstrate a potential therapeutic role for topical camostat for pre- or post-exposure prophylaxis of SARS-CoV-2, which can now be evaluated in a clinical trial.
A fuzzy multi-criteria decision-making approach for the assessment of forest health applying hyper spectral imageries: A case study from Ramsar forest, North of Iran
Authors: KHORRAMİ Behnam , VALİZADEH KAMRAN Khalil
Published: February 2022

The hyperspectral images have so far been widely utilized in monitoring and detecting the changes in a broad range of environmentally related matters. The hyperspectral image analysis yields maps that show spatial dispersion of physical and ecological characteristics of the terrain. Within the scope of the current study, an integrated Fuzzy-MCDM in a Geographic Information Systems (GIS) platform was used to map the health condition of Ramsar forest. Spectral indices can provide different methods for identifying vegetation coverings. For forest health analysis, spectral indices such as NDWI, CRI1, PSRI, PRI, and NDVI were used to infer the causative factors of forest health. The findings highlight the suitability of the used methodology in identifying potential forest statuses, where forest health protection measures can be taken in advance. The results also suggest that the southern and the western aspects of the study area are of “very low” to “low” forest health. Furthermore, the results indicate a high potentiality for applying the spatial MCDM techniques as an effective tool for the forest health investigation.
Ekstraksi Virgin Coconut Oil Menggunakan Mikroba Rhizopus Oligosporuz
Authors: Febrianto Adi Nugroho
Published: February 2022

Proses ekstraksi minyak kelapa dapat dilakukan dengan cara menambahkan Suatu inokulum (mikroba) ke dalam larutan santan dan diinkubasi pada suhu kamar. Minyak yang dihasilkan berupa minyak kelapa murni (virgin coconut oil) atau disebut juga minyak kelapa ekstrak dingin (cold expelled coconut oil). Penelitian ini bertujuan untuk menghasilkan virgin coconut oil dengan bantuan Rhizopus oligosporus. Percobaan dilakukan dengan variasi jumlah ragi Rhizopus oligosporus dari ragi tempe sebesar 0,5 gram: 1 gram : 1,5 gram, dan 2 gram. Hasil percobaan terbaik yang memenuhi SNI diperoleh pada percobaan (batch) III menghasilkan produk minyak 81,80 gram : turbiditas 3.4 NTU dan indeks bias 1,450. Hasil analisis kimia produk tersebut memiliki kadar air 0,2% ; kadar kotoran 0,046 % ; kadar asam lemak bebas 0,52 % ; kadar minyak pelican 1,56 % dan bilangan penyabunan 262,968 mg KOH / gr lemak .
Point of care diagnostics and non-invasive sampling strategy: a review on major advances in veterinary diagnostics
Authors: Bora Mousumi , M Manu , Mathew Dayamon D. , Das Himasri , Bora Durlav Prasad , Barman Nagendra Nath
Published: February 2022

The use of point of care diagnostics (POCD) in animal diseases has steadily increased over the years since its introduction. Its potential application to diagnose infectious diseases in remote and resource limited settings have made it an ideal diagnostic in animal disease diagnosis and surveillance. The rapid increase in incidence of emerging infectious diseases requires urgent attention where POCD could be indispensable tools for immediate detection and early warning of a potential pathogen. The advantages of being rapid, easily affordable and the ability to diagnose an infectious disease on spot has driven an intense effort to refine and build on the existing technologies to generate advanced POCD with incremental improvements in analytical performance to diagnose a broad spectrum of animal diseases. The rural communities in developing countries are invariably affected by the burden of infectious animal diseases due to limited access to diagnostics and animal health personnel. Besides, the alarming trend of emerging and transboundary diseases with pathogen spill-overs at livestock-wildlife interfaces has been identified as a threat to the domestic population and wildlife conservation. Under such circumstances, POCD coupled with non-invasive sampling techniques could be successfully deployed at field level without the use of sophisticated laboratory infrastructures. This review illustrates the current and prospective POCD for existing and emerging animal diseases, the status of non-invasive sampling strategies for animal diseases, and the tremendous potential of POCD to uplift the status of global animal health care.
HIGH PREVALENCE OF DRUG RESISTANT NEISSERIA GONORRHOEAE IN MALES WITH URETHRAL DISCHARGE AT THE STD CLINIC MULAGO HOSPITAL UGANDA
Authors:   George Ndawula1*, Henry Kajumbula1, Fred Nsubuga3, Edgar Kigozi1, Freddie Bwanga1,2
Published: February 2022

Among the treatable sexually transmitted infections (STIs), Neisseria gonorrhoeae is considered to be most important because of its ever evolving antibiotic resistance. Currently third generation cephalosporins are recommended as first-line drugs in many countries. Unfortunately, resistance to these cephalosporins (cefixime and ceftriaxone) has been reported elsewhere. The objectives of the study were to determine the prevalence of Neisseria gonorrhoea in adult males presenting to Mulago hospital with urethral discharge and to determine the level of resistance of Neisseria gonorrhea to the commonly available antimicrobial agents at the clinic focusing on extended-spectrum cephalosporins. In a cross sectional study, we enrolled 112 adult males aged 18-65 yrs with urethral discharge at the STD clinic Mulago Hospital. Prevalence of gonorrhoea was determined based on Gram staining and/or N. gonorrhea isolation at culture. Antimicrobial susceptibility testing was determined with the Kirby-Bauer disk diffusion method and with the Nitrocefin tests for β-lactamase production. Among 112 adult male patients aged 18-65 years with urethral discharge,the prevalence of N. gonorrhea was at 81.3%. Resistance to drugs was identified at the following rates: tetracycline 100%, ciprofloxacin 94.8%, cotrimoxazole 91.4%, penicillin 82.8%, cefixime 20.7%, ceftriaxone 5.2%, spectinomycin 1.7%, and azithromycin 0%. According to this study drug resistance to commonly available antimicrobials for N. gonorrhea is very high among isolates from patients attending the STI clinic, Mulago Hospital Kampala, Uganda. Ceftriaxone, spectinomycin and azithromycin appeared to be the most useful drugs in the treatment of N. gonorrhea infection at the clinic. This work was completed in November 2017.
Fiabilidad y validez de un instrumento de medición del desempeño competitivo de las instituciones de salud mediante las tecnologías de la información y la comunicación
Authors: Ramírez-Pérez José Felipe , López-Torres Virginia Guadalupe , Ramírez-Pérez Alicia del Rosario , Morejón-Valdés Maylevis
Published: February 2022

Desde su surgimiento, la utilización de las tecnologías de la información y la comunicación ha logrado mayores ventajas competitivas en las empresas y organismos públicos, incluyendo el sector salud, aunque sobre este hay poca evidencia científica. El objetivo de la investigación fue validar un cuestionario para la medición del desempeño competitivo de las instituciones de salud del estado de Baja California, mediante el uso de las tecnologías de la información y la comunicación. El enfoque del estudio es cuantitativo, con alcance descriptivo de tipo retrospectivo y diseño no experimental de corte transversal. El cuestionario elaborado con base en la revisión de literatura se aplicó entre septiembre de 2020 y mayo de 2021 a una muestra de profesionales de la salud (n = 203). Constó de 59 ítems, como resultado de la medición de 9 dimensiones, en donde su índice de validez de contenido para n = 13 expertos fue catalogado como adecuado (0.79). La fiabilidad obtenida en la prueba piloto fue alta (alfa de Cronbach = 0.86). Para evaluar la validez de constructo se llevó a cabo un análisis factorial exploratorio, que determinó 9 factores que explican el 84.5 % de la varianza total y una fuerte correlación entre las variables. El instrumento obtenido presentó adecuadas propiedades psicométricas de confiabilidad y validez, que a su vez permitieron medir el impacto que tienen las tecnologías de la información y comunicación sobre el desempeño competitivo de las instituciones de salud.
Concentración espacial de las denuncias por violencia familiar en Ciudad Victoria: un acercamiento mediante la detección de hot spots
Authors: Jurado-Flores Víctor Daniel , Fuentes-Ríos Francisco Javier
Published: February 2022

La violencia familiar es el principal delito cometido a nivel nacional en México. Tamaulipas tiene una tasa de denuncias que se encuentra por encima de la media nacional desde el año 2016 hasta el 2018, destacando el municipio de Vitoria con la tasa más alta en ese período. El objetivo de este trabajo fue identificar la concentración espacial de las denuncias por violencia familiar en Ciudad Victoria y especificar la relación entre las desventajas del vecindario y la ubicación en un hot spot (punto caliente). El estudio se basa en la teoría de la desorganización social y tiene como soporte los datos de la Fiscalía General del Estado de Tamaulipas en el periodo 2016-2018. Para ello, se desarrolló el análisis exploratorio de datos espaciales mediante las técnicas de estimación de densidad de kernel, promedio del vecino más cercano, análisis de hot spot Gi* de Getis-Ord y un análisis confirmatorio mediante una regresión logística binaria, procesamientos desarrollados en el software ArcMap 10.8.1 y en el paquete estadístico R. Los hallazgos indicaron que las denuncias se producen desde un número reducido de unidades geográficas. La prueba del promedio del vecino más cercano mostró que existe agrupamiento estadísticamente significativo (z = - 10.825, P = 0.000). En el análisis Gi* de Getis-Ord se detectó que 602 manzanas (9.8 % del total) son hot spots (al 95 % y 99 % de confianza) de alta incidencia, mientras que la regresión logística confirmó que la cantidad de ocupantes por vivienda y los hogares con jefatura femenina están asociados positivamente con la probabilidad de estar dentro de un hot spot de violencia familiar. El patrón de denuncias mostró poca dispersión geográfica y asociación estadística relevante con las variables de desorganización social.
Insectos asociados a productos alimenticios almacenados en el área urbana de Culiacán, Sinaloa, México
Authors: Torres-Avendaño José Israel , Castillo-Ureta Hipólito , Zazueta-Moreno José Marcial , Torres-Montoya Edith Hilario
Published: February 2022

Los insectos asociados a productos almacenados dañan a una amplia variedad de alimentos en hogares y expendios, provocando baja calidad nutricional e incluso riesgo a la salud de los consumidores. El objetivo de este estudio fue determinar las especies y abundancia de insectos asociados a alimentos secos almacenados en casas y tiendas de abarrotes de la ciudad de Culiacán, Sinaloa. Se obtuvieron productos alimenticios, en casas o tiendas de abarrotes, con indicios de daños por insectos o presencia de los mismos, los cuales fueron trasladados al laboratorio, donde se aislaron los imagos. Los organismos inmaduros y las muestras de alimento seco se depositaron en cámaras de emergencia de adultos debido a que la identificación se llevó a cabo por morfología en la fase de imago. Se recolectaron 181 ejemplares de insectos pertenecientes a 8 especies; de ellas, Oryzaephilus mercator (Fauvel), Necrobia rufipes (De Greer), Plodia interpunctella (Hubner) y Cadra cautella (Walker) son nuevos registros para Sinaloa. En las casas se encontró la mayor cantidad de insectos, principalmente del orden coleoptera (U = 96.000, n = 154, P = 0.004). Las especies N. rufipes, T. castaneum (Herbst) y P. interpunctella fueron las más comunes en los sitios de estudio y en las muestras recolectadas. Por primera vez se caracterizó y se determinó la abundancia de insectos plaga de productos alimenticios almacenados en una zona urbana de Sinaloa, entidad federativa con importancia agraria en México. Ubicar taxonómicamente las especies que infestan productos almacenados ayuda a determinar el riesgo económico y de salud que representan para las zonas donde fueron encontrados. También es útil para desarrollar y aplicar medidas adecuadas de control entomológico, en caso de presentarse una plaga en la zona, lo que mantendrá la calidad e integridad de los productos que se comercializan.
PENGUKURAN KINERJA NON KEUANGAN TERHADAP KINERJA KARYAWAN: EFEK MEDIASI DARI ROLE CLARITY DAN KOMITMEN
Authors: Khusnah Hidayatul , Anugraini Mardiyah
Published: February 2022

This study aims to examine the mediating effect of role clarity and organizational commitment on the effect of non-financial performance measurement on employee performance. In addition to examining the mediating effect, this study also examines the direct influence of non-financial performance measurements on role clarity, organizational commitment, and employee performance. The sample of this research is 153 financial managers of companies that are members of PT. SIER The data analysis technique in this study uses Partial Least Square with WarpPLS 6.0 software. The results of this study indicate that non-financial performance measurement has a positive effect on employee performance, role clarity and organizational commitment. Further results show that organizational commitment has an effect on employee performance. However, for the effect of role clarity on employee performance, it was found that the results did not support the hypothesis, namely, that role clarity had no effect on employee performance. The results of testing the mediation hypothesis found that role clarity was able to fully mediate the effect of non-financial performance measurements on employee performance. While the organizational committee is also able to partially mediate the effect of non-financial performance measurement on employee performance.
PERFORMANCE OF ISLAMIC AND CONVENTIONAL BANKING IN CAMEL ANALYSIS
Authors: Ali Farhan
Published: February 2022

This article tries to compare the financial performance of Islamic banks and conventional banks, to find out which of the two bank models has better performance. The research method used is descriptive with the CAMEL analysis approach, the selected sample is the 2018 monthly financial statements of BRI Syariah, BRI Conventional, Mandiri Syariah, and Mandiri Conventional. The results show that in general the financial performance of conventional banks is better than Islamic banks.
THE PERSPEKTIF THEORY OF PLANNED BEHAVIOR TERHADAP INTENSI PNS UNTUK MELAKUKAN WHISTLEBLOWING
Authors: Biduri Sarwenda , Hariyanto Wiwit , Maryanti Eny , Nurasik Nurasik , Sartika Sartika
Published: February 2022

This study aims to determine attitudes, subjective norms and control behavior on the intentions of civil servants to carry out whistleblowing: a theoretical perspective on planned behavior (study of the Sidoarjo Regency Government). This study has a sample of civil servants (PNS) who have been in accordance with predetermined criteria. The sample of this research is 78 employees. Meanwhile, the analytical tool used is the questionnaire tabulation, data collection in the form of test validity and reliability testing. The data in this study were processed using SPSS version 18.0. The results of the validity and reliability tests for each indicator on the independent variables show > 0.3 and have Cronbach's Alpha > 0.06 so that the data can be said to be valid and reliable. In this study using data analysis tools in the form of multiple regression. Meanwhile, in the t-test, attitude as (X1) has a sig value of 0.237, subjective norm as (X2) has a sig 0.045, controlling behavior as (X3) has a sig value of 0.000. According to the research results, it can be concluded that subjective norms and control behavior affect the intention to do whistleblowing. But attitude does not affect the intention to do whistleblowing.
PENGARUH ENTREPRENEURIAL SUPPORT TERHADAP KINERJA UMKM DI KOTA PASURUAN
Authors: Mufidah Eva , Vita Vita Fibriyani
Published: February 2022

Pertumbuhan ekonomi di Indonesia tidak lepas dari perkembangan usaha mikro. Salah satu indikator yang menunjukkan berkembangnya suatu usaha mikro adalah kinerja. Pertumbuhan usaha mikro di Indonesia, khususnya di Kota Pasuruan sangatlah pesat. Penelitian ini bertujuan untuk mengetahui pengaruh entrepreneurial support (entrepreneurship training, financial support, entrepreneurial marketing dan entrepreneurial networking) terhadap kinerja UMKM di Kota Pasuruan. Teknik sampling yang digunakan dalam penelitian ini adalah purposive sampling dengan jumlah sampel sebanyak 150 UMKM di bidang makanan dan minuman di Kota Pasuruan. Berdasarkan hasil analisis, diketahui bahwa variabel yang mempengaruhi kinerja UMKM di Kota Pasuruan adalah enterprenurial networking, entrepreneurial training dan financial support. Variabel paling berpengaruh adalah entrepreneurial networking dengan koefisien regresi sebesar 0.507.
DETERMINAN STRUKTUR PASAR TENAGA KERJA SEKTOR TRANSPORTASI DI INDONESIA
Authors: Rodhiyawan Wahyu Widodo
Published: February 2022

The development of the digital economy has resulted in the loss of some jobs, the emergence of new jobs, and the possibility of labor shifting between the two. This raises the potential for labor that is not absorbed which of course will cause unemployment problems. With the COVID-19 pandemic, which requires Large-Scale Restrictions (PSBB) which of course affects the transportation sector. This study aims to examine the influence of the digital economy, investment, the COVID-19 pandemic, and the Job Creation Act on the labor market structure of the transportation sector in Indonesia. The research method used is quantitative. The data used is a time series from January 2018 to November 2020. The results of this study indicate that the digital economy has no effect on the labor market structure of the transportation sector in Indonesia. Meanwhile, investment, the COVID-19 pandemic, and the Job Creation Act also each have a significant effect on the labor market structure of the transportation sector in Indonesia. The impact of investment and the COVID-19 pandemic on the labor market structure of the transportation sector in Indonesia is negative. Meanwhile, the effect of the Job Creation Act on the labor market structure of the transportation sector in Indonesia is positive. Simultaneously, the digital economy, investment, the COVID-19 pandemic, and the Job Creation Act affect the labor market structure of the transportation sector in Indonesia.
PENGARUH KOMPETENSI DAN PEMAHAMAN TERHADAP PENGELOLAAN APLIKASI SISTEM KEUANGAN DESA (SISKEUDES) DI KABUPATEN NGANJUK
Authors: Rahayu Dwi Puji , Ambarwati Ambarwati
Published: February 2022

This study aims to determine the effect of human resources consisting of competence, and understanding on the management of village financial system application in villages in Nganjuk district. The research method used is a quantitative research method with primary data obtained from questionnaire data which is measured with a likertscale.The population in this study were all villages in Nganjuk district as many as 264 villages, with the respondents being the siskuedes operator, Village secretary and village treasure, while the sample uses the slovin formula, resulting 73 samples.The research data was processed using the classical assumption test consisting of the Normality Test, Multicollinerity Test and Multiple Linear Regression Test. The results of this study conclude that 1) Competence has a positive and significant effect on the management of village finsncialsysten applications in Nganjuk district .It is evidenced by the acquisition of the t – count value greater than t – table with a significant less than 0,05. 2).Understanding has a positive and significan impact on the management of village financial system applications in Nganjuk district. It is evidenced by the acquisition of the t – count value greater than t – table with a significant less than 0,05.  3). Competence and understanding  together effect the management of village financial system applications in Nganjuk district. It is proven by the acquisition of the calculated F value that is greater than the F table with a significant less than 0,05
ANALISIS PERAN UMKM DALAM PEREKONOMIAN JAWA TIMUR
Authors: Aminy Aisyah
Published: February 2022

Micro, Small and Medium Enterprises (MSME’s) is a form of economic life of most people who have contributed to the economic growth of East Java with the contribution of East Java's GRDP of 54.98 percent. In the last ten years, MSME experienced a significant growth of 4.2 million in 2006, 6.8 million in 2012, and in 2018 it was 9.78 million businesses. Therefore, in this study an analysis of the value added of cooperatives and MSMEs in East Java in the last 3 (three) years, namely 2016, 2017, and 2018 with the aim to determine the role of cooperatives and MSMEs in the economy of East Java. This type of research is quantitative research with the method used is the analysis of value added based on current prices obtained from the multiplication of the ratio of value added to output while to obtain added value at constant prices using the PDRB Constant method. The results showed that in 2016 the contribution of MSME’s value added to the economy of East Java was 56.43 percent, increasing to 56.63 percent in 2017 and in 2018 also increasing to 56.93 percent.
Pengembangan Perangkat Pembelajaran Bimbingan dan Konseling untuk Mengoptimalkan Perkembangan Sosial Anak Kelas I SD
Authors: Chairunnisa Vinda , Mudjiran Mudjiran , Gistituati Nurhizrah
Published: February 2022

This research aims to formulate guidance and counseling learning tool to optimizing social development of stuen and describe the level of appalicability used by theacher or counselor. the mthd used was ADDIE model development. the properness tes was done by five experts and the practicality tes was done by three teacher or counselor. the instrument used were scale likert, questionnaire and Focus Group Discussion (FGD). The data statistic gathered in this research was analyzed by using descriptive statistic analysis and non-parametric statistic analysis. Based on thes results, in general, it was conclueded that the guidance and counseling learning tool's developed was appropriate and could be used to help the teacher or counselor to optimizing social development student.