bluuebunny/crossref_metadata_2025 huggingface dataset:
Adherence Patterns and Dose Response of Physiotherapy for Rotator Cuff Pathology: Longitudinal Cohort Study (Preprint)
Authors: Burns David , Boyer Philip , Razmjou Helen , Richards Robin , Whyne Cari
Published: August 2020

BACKGROUND

Physiotherapy is considered to be essential for the successful operative and nonoperative management of rotator cuff pathology; however, the extent to which patients adhere to assigned physiotherapy activities and how this impacts recovery is unknown.

OBJECTIVE

The purpose of this study was to measure the rate and patterns of participation in physiotherapy for rotator cuff disorders, assess the dose response between physiotherapy activity and recovery, and explore patient factors predictive of physiotherapy participation.

METHODS

We report a prospective longitudinal study of 42 patients undergoing physiotherapy for symptomatic rotator cuff pathology. The patients were issued a smartwatch that recorded inertial sensor data while they performed physiotherapy exercises both in the clinic and in the home setting. A machine learning approach was used to assess total physiotherapy participation from smartwatch inertial data. Primary outcomes were the Disabilities of the Arm Shoulder and Hand and numeric pain rating scale assessed every 4 weeks until 12 weeks follow-up. The relationships between participation, outcomes, and clinical patient variables were assessed in univariable analyses.

RESULTS

Mean physiotherapy exercise participation in clinic and at home were 11 minutes per week and 33 minutes per week, respectively, with patients participating in physiotherapy on 41% of days assigned to treatment. Home physiotherapy participation decreased significantly over time (P=.03). There was a statistically significant and clinically meaningful relationship between cumulative physiotherapy participation and recovery demonstrated by pain scores at 8 weeks (P=.02) and 12 weeks (P=.05) and disability scores at 8 weeks (P=.04) and 12 weeks (P=.04). Low patient expectations and self-efficacy were associated with low rates of physiotherapy participation.

CONCLUSIONS

There was a low rate of participation in home shoulder physiotherapy exercise, and a statistically and clinically significant dose response of physiotherapy on treatment outcome in patients with rotator cuff pathology. The findings highlight the opportunity to develop novel methods and strategies to improve the participation in and efficacy of physiotherapy exercises for rotator cuff disorders.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/17841
A Tailored Web- and Text-Based Intervention to Increase Physical Activity for Latino Men: Protocol for a Randomized Controlled Feasibility Trial (Preprint)
Authors: Gans Kim M , Dulin Akilah , Palomo Vanessa , Benitez Tanya , Dunsiger Shira , Dionne Laura , Champion Gregory , Edgar Rachelle , Marcus Bess
Published: August 2020

BACKGROUND

Latino men in the United States report low physical activity (PA) levels and related health conditions (eg, diabetes and obesity). Engaging in regular PA can reduce the risk of chronic diseases and yield many health benefits; however, there is a paucity of interventions developed exclusively for Latino men.

OBJECTIVE

To address the need for culturally relevant PA interventions, this study aims to develop and evaluate Hombres Saludables, a 6-month theory-based, tailored web- and text message-based PA intervention in Spanish for Latino men. This protocol paper describes the study design, intervention, and evaluation methods for Hombres Saludables.

METHODS

Latino men aged 18-65 years were randomized to either the individually tailored PA internet intervention arm or the nutrition and wellness internet control arm. The PA intervention included 2 check-in phone calls; automated SMS text messages; a pedometer; a 6-month gym membership; access to a private Facebook group; and an interactive website with PA tracking, goal setting, and individually tailored PA content. The primary outcomes were feasibility, acceptability, and efficacy (minutes per week of total moderate-to-vigorous PA assessed via the ActiGraph GT3X+ accelerometer worn at the waist and 7-day physical activity recall at baseline and 6 months). Secondary outcomes examined potential moderators (eg, demographics, acculturation, and environmental variables) and mediators (eg, self-efficacy and cognitive and behavioral processes of change) of treatment effects at 6 months post randomization.

RESULTS

This study was funded in September 2016. Initial institutional review board approval was received in February 2017, and focus groups and intervention development were conducted from April 2017 to January 2018. Recruitment for the clinical trial was carried out from February 2018 to July 2019. Baseline data collection was carried out from February 2018 to October 2019, with a total of 43 participants randomized. Follow-up data were collected through April 2020. Data cleaning and analysis are ongoing.

CONCLUSIONS

We developed and tested protocols for a highly accessible, culturally and linguistically relevant, theory-driven PA intervention for Latino men. Hombres Saludables used an innovative, interactive, web- and text message–based intervention for improving PA among Latino men, an underserved population at risk of low PA and related chronic disease. If the intervention demonstrates feasibility, acceptability, and preliminary efficacy, we will refine and evaluate it in a larger randomized control trial.

CLINICALTRIAL

Clinicaltrials.gov: NCT03196570; https://clinicaltrials.gov/ct2/show/NCT03196570

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/23690
Prevalence of Mental Illnesses in Domestic Violence Police Records: Text Mining Study (Preprint)
Authors: Karystianis George , Simpson Annabeth , Adily Armita , Schofield Peter , Greenberg David , Wand Handan , Nenadic Goran , Butler Tony
Published: August 2020

BACKGROUND

The New South Wales Police Force (NSWPF) records details of significant numbers of domestic violence (DV) events they attend each year as both structured quantitative data and unstructured free text. Accessing information contained in the free text such as the victim’s and persons of interest (POI's) mental health status could be useful in the better management of DV events attended by the police and thus improve health, justice, and social outcomes.

OBJECTIVE

The aim of this study is to present the prevalence of extracted mental illness mentions for POIs and victims in police-recorded DV events.

METHODS

We applied a knowledge-driven text mining method to recognize mental illness mentions for victims and POIs from police-recorded DV events.

RESULTS

In 416,441 police-recorded DV events with single POIs and single victims, we identified 64,587 events (15.51%) with at least one mental illness mention versus 4295 (1.03%) recorded in the structured fixed fields. Two-thirds (67,582/85,880, 78.69%) of mental illnesses were associated with POIs versus 21.30% (18,298/85,880) with victims; depression was the most common condition in both victims (2822/12,589, 22.42%) and POIs (7496/39,269, 19.01%). Mental illnesses were most common among POIs aged 0-14 years (623/1612, 38.65%) and in victims aged over 65 years (1227/22,873, 5.36%).

CONCLUSIONS

A wealth of mental illness information exists within police-recorded DV events that can be extracted using text mining. The results showed mood-related illnesses were the most common in both victims and POIs. Further investigation is required to determine the reliability of the mental illness mentions against sources of diagnostic information.
Learning From Others Without Sacrificing Privacy: Simulation Comparing Centralized and Federated Machine Learning on Mobile Health Data (Preprint)
Authors: Liu Jessica Chia , Goetz Jack , Sen Srijan , Tewari Ambuj
Published: August 2020

BACKGROUND

The use of wearables facilitates data collection at a previously unobtainable scale, enabling the construction of complex predictive models with the potential to improve health. However, the highly personal nature of these data requires strong privacy protection against data breaches and the use of data in a way that users do not intend. One method to protect user privacy while taking advantage of sharing data across users is federated learning, a technique that allows a machine learning model to be trained using data from all users while only storing a user’s data on that user’s device. By keeping data on users’ devices, federated learning protects users’ private data from data leaks and breaches on the researcher’s central server and provides users with more control over how and when their data are used. However, there are few rigorous studies on the effectiveness of federated learning in the mobile health (mHealth) domain.

OBJECTIVE

We review federated learning and assess whether it can be useful in the mHealth field, especially for addressing common mHealth challenges such as privacy concerns and user heterogeneity. The aims of this study are to describe federated learning in an mHealth context, apply a simulation of federated learning to an mHealth data set, and compare the performance of federated learning with the performance of other predictive models.

METHODS

We applied a simulation of federated learning to predict the affective state of 15 subjects using physiological and motion data collected from a chest-worn device for approximately 36 minutes. We compared the results from this federated model with those from a centralized or server model and with the results from training individual models for each subject.

RESULTS

In a 3-class classification problem using physiological and motion data to predict whether the subject was undertaking a neutral, amusing, or stressful task, the federated model achieved 92.8% accuracy on average, the server model achieved 93.2% accuracy on average, and the individual model achieved 90.2% accuracy on average.

CONCLUSIONS

Our findings support the potential for using federated learning in mHealth. The results showed that the federated model performed better than a model trained separately on each individual and nearly as well as the server model. As federated learning offers more privacy than a server model, it may be a valuable option for designing sensitive data collection methods.

CLINICALTRIAL
Effects of a Mobile App Called Quittr, Which Utilizes Premium Currency and Games Features, on Improving Engagement With Smoking Cessation Intervention: Pilot Randomized Controlled Trial (Preprint)
Authors: Bindoff Ivan , Ling Tristan R , Gee Peter , Geelan Benjamin , Ferguson Stuart G , Peterson Gregory M
Published: August 2020

BACKGROUND

Numerous mobile health (mHealth) apps have been developed to support smokers attempting to quit smoking. Although these apps have been reported to be successful, only modest improvements in the quit rate have been measured. It has been proposed that efforts to improve user engagement and retention may improve the quit rate further. Owing to the high cost of smoking-related disease, it is considered worthwhile to pursue even small improvements.

OBJECTIVE

The aim of this study was to test a novel smartphone app that leverages premium currency strategies developed by the mobile games industry in an attempt to improve engagement and retention with a smoking cessation intervention.

METHODS

We designed and developed a smoking cessation app called “Quittr” in line with previously developed smoking cessation mHealth apps. In addition to this established framework, we added a stand-alone fully featured city-building clicker-style game called “Tappy Town,” and a premium virtual currency called “QuitCoins.” The user earns QuitCoins for using the app in a way that contributes positively toward their quit attempt, and they can redeem these coins in Tappy Town for bonuses. To establish whether these features improved engagement and retention, we ran a 5-month randomized controlled trial where the intervention group had the full app with the extra games features, while the control group had the standard app only. Recruitment was performed via web-based advertising. Participants (N=175) had no direct contact with the researchers or other support staff.

RESULTS

No significant differences in terms of engagement, retention, or smoking outcomes were found between the control and intervention groups. However, survey data indicated that the majority of the participants valued Tappy Town (10/17, 59%) and the QuitCoins rewards system (13/17, 77%). Usage data also suggested that Tappy Town was widely played and was generally appealing to users (mean total time spent in app, control group: 797 seconds vs intervention group: 3502 seconds, P<.001). Analysis of the results suggests that users in the intervention group may have been negatively affected by the aspects of the chosen design, and some theories were explored to explain this unexpected outcome.

CONCLUSIONS

Although the novel features of the Quittr app failed to improve the key outcomes measured in this study, there were enough positive indications to warrant further exploration of the concept. Additional research will be required to identify and correct any design flaws that may have adversely affected our participants before a follow-up study can be completed.

CLINICALTRIAL

Australian and New Zealand Clinical Trials Register ACTRN12617000491369; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372661&isReview=true
"Hepatitis B vaccination status and factors influencing Hepatitis B vaccination status in Health care workers of two Aga Khan secondary care hospitals at Sindh- a cross sectional study" (Preprint)
Authors: Muhammad Salman
Published: August 2020

BACKGROUND

Health care workers (HCWs) are at greatest risk for acquiring Hepatitis B Virus infection because of needle stick injuries (NSIs) and occupational exposure to potentially infectious blood and body fluids as they deal with patients with different infections. Hepatitis B vaccination protects against the infection. Screening and vaccination against Hepatitis B is recommended for all HCWs.

OBJECTIVE

I. To estimate the prevalence of Hepatitis B vaccination among HCWs of Private Aga Khan Secondary care hospitals at Sindh.
II. To determine factors influencing Hepatitis B vaccination among HCWs of Private Aga Khan Secondary care hospitals at Sindh.

METHODS

A cross sectional study will be conducted in two Aga Khan Secondary care hospitals at Sindh (Aga Khan Maternal and Child Care Center Hyderabad and Aga Khan Hospital for Women, Karaimabad, Karachi). Sample size calculated is 264 with 10% non-respondent rate. A pre-tested structured questionnaire will be devised to collect information from study participants, data will be collected from HCWs of the designated hospitals. Analysis will be done using STATA 15.

RESULTS

NA as it is a protocol

CONCLUSIONS

he present work will help in identifying overall vaccination coverage and factors influencing HBV vaccination coverage, increasing access to vaccination will improve Hepatitis B vaccine coverage among HCWs that will enable them to remain safe from occupational exposure on daily basis not only this but they will have less chance to acquire HBV or transmit infection to others.

CLINICALTRIAL

NA. This is not a trial
Quality of Life and Multilevel Contact Network Structures Among Healthy Adults in Taiwan: Online Participatory Cohort Study (Preprint)
Authors: Yen Tso-Jung , Chan Ta-Chien , Fu Yang-Chih , Hwang Jing-Shiang
Published: August 2020

BACKGROUND

People’s quality of life diverges on their demographics, socioeconomic status, and social connections.

OBJECTIVE

By taking both demographic and socioeconomic features into account, we investigated how quality of life varied on social networks using data from both longitudinal surveys and contact diaries in a year-long (2015-2016) study.

METHODS

Our 4-wave, repeated measures of quality of life followed the brief version of the World Health Organization Quality of Life scale (WHOQOL-BREF). In our regression analysis, we integrated these survey measures with key time-varying and multilevel network indices based on contact diaries.

RESULTS

People’s quality of life may decrease if their daily contacts contain high proportions of weak ties. In addition, people tend to perceive a better quality of life when their daily contacts are face-to-face or initiated by others or when they contact someone who is in a good mood or someone with whom they can discuss important life issues.

CONCLUSIONS

Our findings imply that both functional and structural aspects of the social network play important but different roles in shaping people’s quality of life.
Do People Trust in Robot-Assisted Surgery? Evidence from Europe (Preprint)
Authors: Torrent-Sellens Joan , Jiménez-Zarco Ana , Saigí-Rubió Francesc
Published: August 2020

BACKGROUND

Increasingly intelligent and autonomous robots are destined to have a huge impact on our society. Their adoption, however, represents a major change to the healthcare sector’s traditional practices, which, in turn, poses certain challenges. To what extent is it possible to foresee a near-future scenario in which minor routine surgery is directed by robots? And what are the patients’ or general public’s perceptions of having surgical procedures performed on them by robots, be it totally or partially? A patient’s trust in robots and AI may facilitate the spread and use of such technologies.

OBJECTIVE

The goal of our study was to establish the factors that influence how people feel about having a medical operation performed on them by a robot.

METHODS

We used data from a 2017 Flash Eurobarometer (number 460) of European Commission with 27,901 citizens aged 15 years and over in the 28 countries of the European Union. The research designs and tests a technology acceptance model (TAM). Logistic regression (odds ratios, OR) to model the predictors of trust in robot-assisted surgery was calculated through motivational factors, robots using experience and sociodemographic independent variables.

RESULTS

The negative relationship between most of the predictors of ease of use, expected benefits and attitude towards robots, and confidence in robot-assisted surgery was contrasted. The only non-sociodemographic predictor variable that has a positive relationship with trust in robots participating in a surgical intervention is previous experience in the use of robots. In this context, we analyze the confidence predictors for three different levels of robot use experience (zero use, average use, and high use). The results obtained indicate that, as the experience of using robots increases, the predictive coefficients related to information, attitude and perception of robots become more negative. Research results also determined that variables of a sociodemographic nature played an important predictive role. It was confirmed that the effect of experience on trust in robots for surgical interventions was greater among men, people between 40 and 54 years old, and those with higher educational levels.

CONCLUSIONS

Despite the considerable benefits for the patient that the use of robots can bring in a surgical intervention, the results obtained show that trust in robots goes beyond rational decision-making. By contrasting the reasons that generate trust and mistrust in robots, especially by highlighting the experience of use as a key element, the research makes a new contribution to the state of the art and draws practical implications of the use of robots for health policy and practice.
Public concerns during the COVID-19 lockdown – a multicultural cross-sectional study in three countries (Preprint)
Authors: Emodi-Perlman Alona , Eli Ilana , Uziel Nir , Smardz Joanna , Khehra Anahat , Gilon Efrat , Wieckiewicz Gniewko , Levin Liran , Wieckiewicz Mieszko
Published: August 2020

BACKGROUND

In late December 2019, a new pandemic caused by the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection, began to spread around the world. The new situation gave rise to severe health threats, economic uncertainty, and social isolation, causing potential deleterious effects on the physical and mental health of the people.

OBJECTIVE

This study aimed to evaluate worries, anxiety and depression in the public during the initial Coronavirus Disease 2019 (COVID-19; Coronavirus) pandemic lockdown in three culturally different communities: Middle Eastern (Israel), European (Poland) and North American (Canada).

METHODS

A cross-sectional online anonymous survey was conducted simultaneously in Israel, Poland and Canada during the lockdown periods in these countries. The survey included a demographic questionnaire, a questionnaire on original personal concerns regarding the Coronavirus pandemic and the Patient Health Questionnaire-4 (PHQ-4) which is a brief screening tool used for assessing anxiety and depression. A total of 2207 people successfully completed the survey. The data obtained from the survey were statistically analysed.

RESULTS

The results of the survey showed that Poles were the most concerned about being infected by the virus, with higher scores found among women and elders. Canadians worried the most about their finances, relations with relatives and friends and both physical and mental health, while Poles, despite being the most concerned about virus contamination, worried the least about their physical health and Israeli worried the least about their mental health and relations with relatives and friends. Canadians obtained the highest total score in PHQ-4, as well as in both the anxiety and depression subscales of the questionnaire, while the scores of Israelis were the lowest. All the findings were statistically significant.

CONCLUSIONS

The study showed that various factors should be considered while formulating appropriate solutions in emergency circumstances such as a pandemic. Understanding these factors will aid in the development of response strategies to mitigate the adverse effects of stress, social isolation and uncertainty on the well-being and mental health of culturally different societies.
Efficiency, Usability, and Outcomes of Proctored Next-Level Exams for Proficiency Testing in Primary Care Education: Observational Study (Preprint)
Authors: Schoenmakers Birgitte , Wens Johan
Published: August 2020

BACKGROUND

The COVID-19 pandemic has affected education and assessment programs and has resulted in complex planning. Therefore, we organized the proficiency test for admission to the Family Medicine program as a proctored exam. To prevent fraud, we developed a web-based supervisor app for tracking and tracing candidates’ behaviors.

OBJECTIVE

We aimed to assess the efficiency and usability of the proctored exam procedure and to analyze the procedure’s impact on exam scores.

METHODS

The application operated on the following three levels to register events: the recording of actions, analyses of behavior, and live supervision. Each suspicious event was given a score. To assess efficiency, we logged the technical issues and the interventions. To test usability, we counted the number of suspicious students and behaviors. To analyze the impact that the supervisor app had on students’ exam outcomes, we compared the scores of the proctored group and those of the on-campus group. Candidates were free to register for off-campus participation or on-campus participation.

RESULTS

Of the 593 candidates who subscribed to the exam, 472 (79.6%) used the supervisor app and 121 (20.4%) were on campus. The test results of both groups were comparable. We registered 15 technical issues that occurred off campus. Further, 2 candidates experienced a negative impact on their exams due to technical issues. The application detected 22 candidates with a suspicion rating of >1. Suspicion ratings mainly increased due to background noise. All events occurred without fraudulent intent.

CONCLUSIONS

This pilot observational study demonstrated that a supervisor app that records and registers behavior was able to detect suspicious events without having an impact on exams. Background noise was the most critical event. There was no fraud detected. A supervisor app that registers and records behavior to prevent fraud during exams was efficient and did not affect exam outcomes. In future research, a controlled study design should be used to compare the cost-benefit balance between the complex interventions of the supervisor app and candidates’ awareness of being monitored via a safe browser plug-in for exams.
The optimization of ultrasonic method for the extraction of Pumpkin seed (Cucurbita maxima)
Authors: Irnawati Irnawati , Riyanto Sugeng , Martono Sudibyo , Rohman Abdul
Published: August 2020

The purpose of the present study was to determine the optimal ultrasound-assisted extraction (UAE) conditions (sample-to-solvent ratio, ultrasonic power, and time) for the extraction of pumpkin seed oil.  Pumpkin seed oil was analyzed for yield, 2.2’-Diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, and total phenolic content.  Soxhlet extraction methods were assessed for comparison.  The Box Behnken design (BBD) was applied to optimize UAE conditions.  The optimum UAE conditions were obtained using sample-to-solvent ratio of 1:10 mL g-1, ultrasonic power of 150 Watt in 15 min extraction time.  Compared with Soxhlet extraction methods, UAE exhibited lower oil yield and total phenolic content but had higher DPPH scavenging activity.  The advantage of ultrasonic-assisted extraction was clearly reduction of extraction duration.
In Vitro Antiaging Analysis of Topical Pharmaceutical Preparation Containing Mixture of Strawberry Fruit, Pomelo Peel, and Langsat Fruit Extracts
Authors: Lukitaningsih Endang , Saputro Anjar Hermadi , Widiasri Mirna , Khairunnisa Nibras , Prabaswari Nisrina , Kuswahyuningsih Rina
Published: August 2020

The previous research has discovered that strawberry fruit, pomelo peel and langsat fruit peel have antioxidant activity. This research aimed to put the extract combination into several formula of gel and cream. Extract will be formulated into two gels with Natrium Carboxyl Methyl Cellulose as gelling agent for Formula 1 and Synthalen for Formula 2. Whereas there are three cream formulations with Glyceril Mono Stearat as surfactant for Formula 3, Polawax for Formula 4, and Simulsol 165 for Formula 5. Natrosol HBr was added to Formula 3 as thickening agent and Keltrol CG-SFT added to Formula 5. After five formulas being made, their stability was tested using climatic chamber within 30 days. Physical stability parameters were spreadability, stickiness, pH, viscosity, separation degree, and syneresis test. The chemical properties evaluation of the formula was done by measuring radical 2,2-difenyl-1-pikrylhidrazil (DPPH) scavenging activity percentage, anti-collagenase activity, anti-tyrosinase activity, and anti-elastase activity. The results showed that all of formulas have good activity in scavenging DPPH radical, anti-elastase, anti-collagenase and anti-tyrosinase as well. In addition, all formulas have good stability. There is no change in appearance after three times freeze-thaw cycle. Therefore, it was concluded that all formula can be developed as topical preparation for antiaging.
STRATEGI CAMP DALAM NOVEL HIDING MY CANDY KARYA LADY CHABLIS
Authors: Saraswati Sri
Published: August 2020

This study aims at discussing about the forms of Camp strategies as well as elaborating the purpose of its application in Lady Chablis’ Hiding My Candy. Hiding My Candy tells a story of a transgender name The Doll who fights for her survival among patriarchal community. To answer the objectives of the research, Moe Meyer’s Camp theor y will be applied. In the book of the Politics and Poetics of Camp, Meyer defines Camp as the total body of performative practices and strategies used to enact a queer identity, with enactment defined as the production of social visibility. The emergence of Camp as a survival strategy appears due to the challenge of transgender discrimination resulted by heteronormativity restraint. The study result shows that transgender survival can be divided into three aspects i.e. social visibility, alternative normative and transgender empowerment. Those transgender survival’s aspects can be achieved by applying the Camp strategies. Those strategies include parody Camp strategy, humor Camp strategy, strategy of posing (costume, gesture and speech act) and strategy of life in performance.Penelitian ini dilakukan untuk mengulik bentuk-bentuk strategi Camp dan tujuan penerapannya melalui novel Hiding My Candy karya Lady Chablis. Hiding My Candy merupakan sebuah novel yang merepresentasikan upaya kebertahanan transgender yang dilakukan oleh tokoh The Doll. Adapun pendekatan yang akan digunakan dalam penelitian ini adalah teori Camp oleh Moe Meyer. Dalambuku the Politics and Poetics of Camp, Moe Meyer mendefinisikan istilah Camp sebagai total keseluruhan praktik dan strategi untuk menunjukkan identitas queer kaum marjinal, dalam hal ini transgender, kepada masyarakat (visibilitas sosial). Lazimnya, masyarakat heteronormatif menganggap transgender sebagai liyan sehingga keberadaan mereka seringkali terpinggirkan. Maka, tujuan dari penerapan strategi Camp adalah untuk menjamin kebertahanan kaum transgender dalam masyarakat. Muatan kritik terhadap heteronormativitas juga tampak nyata dalam penerapan strategi Camp . Sasaran kritik tersebut adalah pemapanan konstruksi gender normatif serta eksklusifitas kaum heteroseksual yang menjadikan kaum marginal seperti transgender tersisihkan. Berdasarkan hasil penelitian ditemukan bahwa bentuk-bentuk strategi Camp dapat dirinci sebagai berikut; strategi parodi Camp, strategi humor Camp, strategy of posing (kostum, gestur dan gaya bicara) serta strategi hidup dalam pertunjukkan.Penerapan strategi Camp tersebut ditujukan sebagai upaya untuk meraih kebertahanan transgender. Selanjutnya, kebertahanan transgender dapat dicerminkan melalui visibilitas sosial, terbentuknya wacana normalitas alternatif dan pemberdayaan transgender
MENEROPONG GENDER MELALUI KACAMATA GENDERLES: SEBUAH PEMBACAAN BUTLERIAN TERHADAP ANCILLARY JUSTICE KARYA ANN LECKIE
Authors: Farida Hana
Published: August 2020

Penelitian ini bertujuan untuk menyajikan bagaimana kategorisasi gender yang terkesan kaku dipresentasikan sebagai performativitas sosial yang cair dan tidak stabil, juga bagaimana norma genderless yang diajukan pengarang dapat menunjukkan pandangannya akan norma gender. Penelitian ini dilakukan dengan menggunakan teori gender milik Judith Butler. Melalui pemikirannya akan gender sebagai konstruksi sosial, Norma gender, terutama gender biner, dalam novel ini dideskripsikan bersama norma genderless untuk mendapatkan suatu perbandingan diantara mereka. Dengan kacamata genderless, norma gender dalam novel ini disajikan pengarang sebagai suatu konstruksi sosial yang menuntut subjeknya untuk terlibat dalam performativitas gender guna diakui keberadaannya. Namun, begitu pula dengan norma genderless. Norma genderless dalam novel ini ternyata juga merupakan bentuk lain dari praktek gender. dengan kata lain, norma genderless tidak bisa terlepas dari gender dan juga merupakan norma gender.
MITOS KECANTIKAN DALAM CERPEN-CERPEN DWI RATIH RAMADHANY
Authors: Julian Royyan
Published: August 2020

This study highlights the myth of beauty in short stories written by Dwi Ratih Ramadhany, which are “Janda Sungai Gayam” and “Perempuan Bisu dan Cermin Ratu”. The perspective utilized in this study is the myth of beauty by Naomi Wolf. The results are: (1) both the short stories illustrate standards of beauty identified by long black hair, long neck, sensual lips, body fragrant, white-toned-smooth-skin, and slim body; (2) in both short stories, the quality of beauty refers to behaviors that could arouse an excitement rather than merely consider physical appearance;(3) regarding beauty not as an intrinsic quality, it is affected by external factors, for instance cosmetic and supernatural powers. Myth of beauty in both short stories stands on the runway of men’s interest and taste, and women’s motive toachieve resources provided by men, which are called loyalty, recognition, praise and charm.Kajian ini mengangkat isu mitos kecantikan dalam cerpen-cerpen Dwi Ratih Ramadhany, yakni "Janda Sungai Gayam” dan “Perempuan Bisu dan Cermin Ratu”. Perspektif yang digunakan adalah mitos kecantikan Naomi Wolf. Hasilnya antara lain: (1) kedua cerpen tersebut menggambarkan bahwa cantik memiliki standar baku rambut hitam panjang, leher jenjang, bibir merekah, tubuh wangi, kulit kencang-putih-mulus, dan langsing; (2) dalam cerpen-cerpen tersebut, sesungguhnya kualitas cantik lebih merujuk pada perilaku yang dapat membangkitkan gairah daripada penampakan fisik; (3) karena cantik bukan merupakan kualitas instrinsik, ia dipengaruhi oleh faktor-faktor eksternal, yaitu kosmetik dan kekuatan supranatural. Mitos kecantikan dalam kedua cerpen tersebut berdiri di atas landasan kepentingan dan selera laki-laki, serta motif perempuan untuk mendapatkan sumber daya yang disediakan oleh laki-laki, yaitu kesetiaan, pengakuan, pujian, dan keterpesonaan.
MENGUNGKAP KEBUNGKAMAN DALAM PRODUKTIVITAS FIKSI POP ISLAMI PENERBIT MIZAN
Authors: Cantini Cucum
Published: August 2020

This research focus on the discourse of Syiah that alleged to Mizan over the first publication of Dialog Sunni-Syiah which published at 1983. Despite of that negative justification, Mizan publisher still exist and productive, especially for producing pop-islamic fiction. By using Pierre Macherey’s literary production theory, spoken and unspoken, then found a ideological islamization project and also an anti-western effort in the other pop-islamic fiction by realizing it through figuration and symbol inside the text; hidayah, islam figure, moslem gathering, ideal by wearing hijab, Arabian’s figure domination, history of islamic resistance, and preferring middle east background. Therefore, unconsciously, pop-islamic fiction reducing the negative image of Mizan as pop-islamic publisher as well as showing the existence of islamic power. Mizan’s presence appears because of the enthusiasm of intellectuals to the islamic ideas books, especially about Islam Iran Revolution at 1979. By the sensitivity of the discourse in Orde Baru era, then Mizan publisher be a  part of negative image in islam. By the Mizan’s productivity producing pop books then the more the image faded, simultaneously awaken islamic power in Indonesia’s popular culture.Keywords: Pop-islamic fiction, Mizan Publisher, spoken and unspoken , silences
Shame and Alienation in Kafka’s The Metamorphosis
Authors: Minar Karla Sharin , Sutandio Anton
Published: August 2020

This article explores Sartre’s concept of shame and alienation in Kafka’s The Metamorphosis through the portrayal of the protagonist.  By focusing on the interpretation of the characteristics of Gregor Samsa through New Criticism approach, this article reveals that shame and alienation may occur when a person realizes that one is judged by others and sees oneself through the eyes of others.  This way of looking at one’s identity is problematic because it creates complexity within the existence of the self.  Through his fantastical transformation into an insect, Gregor cannot help but seeing himself from his family’s point of view.  Instead of fighting for himself, he is made to believe that he deserves to be alienated.  From the analysis of the protagonist, it is revealed that his being selfess and dutiful in a way trigger the shame and alienation that result in his submission to death.    Keywords: alienation, Kafka, Sartre, shame
NOVEL CHARLOTTE KARYA DAVID FOENKINOS: SEBUAH NARASI TENTANG DISKRIMINASI, RASISME, DAN HOLOCAUST
Authors: Intan Tania
Published: August 2020

The Nazi ruling since 1933 made no secret of his dislike of Jews. Adolf Hitler even declared that "rational antisemitism must lead to a system of legal opposition, the ultimate goal of wiping out all Jews" (Mein Kampf, 1925: 27). He also developed the idea that Jews are the evil race that dominates the world. Nazi anti-Semitism is instilled in religious situations and in a political context. Then, the Nazis added a further dimension, racial anti-semitism. With the logic that Jews are not religious but racial communities, the Nazis launched various aggressions in the form of discriminatory, racist, and Holocaust. This dark phenomenon in human history is revealed in Charlotte's novel by David Foenkinos, a French writer who often receives literary awards. The discussion will be conducted by descriptive analysis method through structural approach which includes assessment of character, background, and point of view. Key words : Discrimination, Racism, Holocaust, Charlotte
Pansomatostatin Agonist Pasireotide Long-Acting Release for Patients with Autosomal Dominant Polycystic Kidney or Liver Disease with Severe Liver Involvement
Authors: Hogan Marie C. , Chamberlin Julie A. , Vaughan Lisa E. , Waits Angela L. , Banks Carly , Leistikow Kathleen , Oftsie Troy , Madsen Chuck , Edwards Marie , Glockner James , Kremers Walter K. , Harris Peter C. , LaRusso Nicholas F. , Torres Vicente E. , Masyuk Tatyana V.
Published: August 2020

Background and objectives

We assessed safety and efficacy of another somatostatin receptor analog, pasireotide long-acting release, in severe polycystic liver disease and autosomal dominant polycystic kidney disease. Pasireotide long-acting release, with its broader binding profile and higher affinity to known somatostatin receptors, has potential for greater efficacy.

Design, setting, participants, & measurements

Individuals with severe polycystic liver disease were assigned in a 2:1 ratio in a 1-year, double-blind, randomized trial to receive pasireotide long-acting release or placebo. Primary outcome was change in total liver volume; secondary outcomes were change in total kidney volume, eGFR, and quality of life.

Results

Of 48 subjects randomized, 41 completed total liver volume measurements (n=29 pasireotide long-acting release and n=12 placebo). From baseline, there were −99±189 ml/m absolute and −3%±7% change in annualized change in height-adjusted total liver volume (from 2582±1381 to 2479±1317 ml/m) in the pasireotide long-acting release group compared with 136±117 ml/m absolute and 6%±7% increase (from 2387±759 to 2533±770 ml/m) in placebo (P<0.001 for both). Total kidney volumes decreased by −12±34 ml/m and −1%±4% in pasireotide long-acting release compared with 21±21 ml/m and 4%±5% increase in the placebo group (P=0.05 for both). Changes in eGFR were similar between groups. Among the n=48 randomized, adverse events included hyperglycemia (26 of 33 [79%] in pasireotide long-acting release versus four of 15 [27%] in the placebo group; P<0.001), and among the 47 without diabetes at baseline, 19 of 32 (59%) in the pasireotide long-acting release group versus one of 15 (7%) in the placebo group developed diabetes (P=0.001).

Conclusions

Another somatostatin analog, pasireotide long-acting release, slowed progressive increase in both total liver volume/total kidney volume growth rates without affecting GFR decline. Participants experienced higher frequency of adverse events (hyperglycemia and diabetes).

Clinical Trial registry name and registration number

Pasireotide LAR in Severe Polycystic Liver Disease, NCT01670110

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_08_28_CJN13661119.mp3
A Probe into the Fate of Women in the Evolution of Society—A Brief Analysis of Amanda in Tennessee Williams’ The Glass Menagerie
Authors: Tiehu Zhang
Published: August 2020

Tennessee Williams is the most famous southern American playwright in twentieth century (Adler, 1994). He is known for his strong southern cultural background, especially southern women educated in a traditional gentlewoman style. The southern women of Tennessee believed that their traditional culture was the essence of human civilization and therefore of considerable value. However, such values could not be recognized in the modern industrial society. Most of these women were sensitive and tender, suffering from industrialized society, full of all sorts of evils, and they had turned to traditional culture to seek mental peace and shelter for the moment, so they again became a lonely and frustrated. While they refused to change their cultural identity, they had to live in a modern, industrialized society that did not belong to them. Therefore, they were regarded as people living in the cultural gap, and eventually became the victims of the confrontation between traditional southern culture and modern industrial culture. As one of the most contradictory and dramatic characters in the play, Amanda is also one of the unique images of women in American drama. As Tennessee said when introducing the characters in the play, “the portrayal of Amanda is by no means derived from a specific archetype”.
Model Pemberdayaan Perempuan dalam Meningkatkan Profesionalitas dan Daya Saing untuk Menghadapi Komersialisasi Dunia Kerja
Authors: Sulistyowati Tutik
Published: August 2020

Model Pemberdayaan Perempuan dalam Meningkatkan Profesionalitas dan Daya Saing untuk Menghadapi Komersialisasi Dunia KerjaTutik Sulistyowati1Jurusan Kesejahteraan Sosial Fakultas Ilmu Sosial dan Politik Universitas Muhammadiyah Malang, Jln. Raya Tlogomas no. 246, Malang 65144;. *Email : sulistyowati_tutik@yahoo.co.idAbstract :Komersialisasi dunia kerja mensyaratkan profesionalitas dan daya saing dari pencari kerja, baik laki-laki maupun perempuan. Perempuan  selama ini secara gender diidentikkan sebagai pekerja domestik, tentunya memerlukan perjuangan yang besar untuk bisa masuk dalam komersialisasi dunia kerja. Perjuangan ini memerlukan dukungan dari seluruh komponen masyarakat baik laki-laki maupun perempuan. Tulisan ini mencoba untuk memberikan alternatif sebagai salah satu upaya untuk meningkatkan profesionalitas dan daya saing perempuan dalam komersialisasi dunia kerja, dengan membuat model pemberdayaan perempuan. Tujuan pemberdayaan perempuan sebagai sumberdaya manusia dalam pembangunan, adalah diharapkan agar memiliki profesionalitas dan daya saing dalam komersialiasai dunia kerja.Keywords :Pemberdayaan perempuan, komersialisasi dunia kerja.
SURVIVAL STRATEGY FOR WOMEN WITH DISABILITIES AS HEAD OF FAMILY
Authors: Astutik Juli
Published: August 2020

People with disabilities have physical limitations and mental disorders. According to Law No. 8 of 2016 concerning persons with disabilities, people with disabilities are those who experience physical, intellectual, mental and sensory limitations for a long time in interacting with the environments who may experience obstacles and difficulties in participating fully and effectively with other citizens based on equal rights. In relates to that, women with disabilities still experience some social discrimination such as social exclusion, marginalization, stereotypes and violence which may results poverty, unemployment, and life deprivation experienced by women with disabilities as heads of households. With the discrimination they experienced, women with disabilities as human beings always tries to carry out survival strategies to meet their life and family needs. Economic problems experienced by women with disabilities makes them have to carry out a survival strategy. As an analytical tool in this study, researchers used the Subsistence Ethics Theory by Scott (1989). In the Ethical Theory of Subsistence, there are three ways of survival mechanisms, among others are to tighten spending, to have a side job, and to get help from networks outside the family. Using descriptive qualitative research, data was collected through observation, interview and documentation techniques. The data was then analyzed through the process of data reduction, data presentation and verification. The data validation uses source triangulation techniques, technical triangulation and time triangulation. From the results of the study, it can be concluded that most of the research subjects used survival mechanisms by tightening expenditures in order to increase daily expenses. In addition, they have side jobs as farm laborers, odd jobs, and also tailors; as well as utilize the local government aid to meet their daily needs.
Teaching Data Analytics in a Collaborative Team Environment
Authors: Shawver Tara J. , Shawver Todd A.
Published: August 2020

Accounting professionals have access to the data that can help businesses develop a strategic advantage and remain competitive in today's fast-paced business environment. Data analytics and teamwork skills are essential for all accountants, finance professionals, and business managers. This manuscript includes a case designed to provide students with practice analyzing data, working collaboratively as a team to prepare and present meaningful reports for management. Skill development is concentrated on data analytics, data visualizations, teamwork, and written communication.
Structural Alterations in Deep Brain Structures in Type 1 Diabetes
Authors: Filip Pavel , Canna Antonietta , Moheet Amir , Bednarik Petr , Grohn Heidi , Li Xiufeng , Kumar Anjali F. , Olawsky Evan , Eberly Lynn E. , Seaquist Elizabeth R. , Mangia Silvia
Published: August 2020

Even though well known in type 2 diabetes, the existence of brain changes in type 1 diabetes (T1D) and both their neuroanatomical and clinical features are less well characterized. To fill the void in the current understanding of this disease, we sought to determine the possible neural correlate in long-duration T1D at several levels, including macrostructural, microstructural cerebral damage, and blood flow alterations. In this cross-sectional study, we compared a cohort of 61 patients with T1D with an average disease duration of 21 years with 54 well-matched control subjects without diabetes in a multimodal MRI protocol providing macrostructural metrics (cortical thickness and structural volumes), microstructural measures (T1-weighted/T2-weighted [T1w/T2w] ratio as a marker of myelin content, inflammation, and edema), and cerebral blood flow. Patients with T1D had higher T1w/T2w ratios in the right parahippocampal gyrus, the executive part of both putamina, both thalami, and the cerebellum. These alterations were reflected in lower putaminal and thalamic volume bilaterally. No cerebral blood flow differences between groups were found in any of these structures, suggesting nonvascular etiologies of these changes. Our findings implicate a marked nonvascular disruption in T1D of several essential neural nodes engaged in both cognitive and motor processing.
Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms
Authors: Ward Natasha C. , Lui Jen Bon , Hernandez Rosmely , Yu Liping , Struthers Mary , Xie Jenny , Santos Savio Alicia , Dwyer Connor J. , Hsiung Sunnie , Yu Aixin , Malek Thomas R.
Published: August 2020

Low-dose interleukin-2 (IL-2) represents a new therapeutic approach to regulate immune homeostasis to promote immune tolerance in patients with autoimmune diseases, including type 1 diabetes. We have developed a new IL-2–based biologic, an IL-2/CD25 fusion protein, with greatly improved pharmacokinetics and pharmacodynamics when compared with recombinant IL-2 to enhance this type of immunotherapy. In this study, we show that low-dose mouse IL-2/CD25 (mIL-2/CD25), but not an equivalent amount of IL-2, prevents the onset of diabetes in NOD mice and controls diabetes in hyperglycemic mice. mIL-2/CD25 acts not only to expand regulatory T cells (Tregs) but also to increase their activation and migration into lymphoid tissues and the pancreas. Lower incidence of diabetes is associated with increased serum levels of IL-10, a cytokine readily produced by activated Tregs. These effects likely act in concert to lower islet inflammation while increasing Tregs in the remaining inflamed islets. mIL-2/CD25 treatment is also associated with lower anti-insulin autoantibody levels in part by inhibition of T follicular helper cells. Thus, long-acting mIL-2/CD25 represents an improved IL-2 analog that persistently elevates Tregs to maintain a favorable Treg/effector T cell ratio that limits diabetes by expansion of activated Tregs that readily migrate into lymphoid tissues and the pancreas while inhibiting autoantibodies.