bluuebunny/crossref_metadata_2025 huggingface dataset:
Wideband Millimeter-Wave Perforated Cylindrical Dielectric Resonator Antenna Configuration
Authors: Albakosh Waled , Asfour Rawad , Abdou Tarek S. , Khalil Yas , Khamas Salam K.
Published: March 2024

This article delves into the capabilities of 3D-printed millimeter-wave (mmWave) layered cylindrical dielectric resonator antennas (CDRAs). The proposed design yielded promising results, boasting a remarkable 53% impedance bandwidth spanning the frequency spectrum from 18 to 34 GHz. Furthermore, the axial ratio (AR) bandwidth achieved an impressive 17%, coupled with a maximum gain of 13.3 dBic. These notable results underscore the efficacy of the proposed design, positioning it as a viable solution for applications in Beyond 5G (B5G). A novel assembly technique was also investigated, employing additive manufacturing to seamlessly merge two layers with distinct dielectric constants into a singular layer. This innovative approach systematically eliminates the potential for air gaps between layers, enhancing the antenna’s overall performance. This approach exhibited potential, particularly in the performance of a millimeter-wave circularly polarized (CP) cylindrical DRA featuring a perforated coating layer. The synergy between measurements and simulations demonstrates a remarkable alignment, providing robust validation of the effectiveness of the proposed design.
Silent Intruder: Unusual Presentation of Neurocysticercosis in an HIV-Infected Patient from the Far Northern Brazilian Amazon
Authors: Galan Luis E. B. , Gerolin Letícia R. M. , Carvalho Tháilla J. M. , Filardi Eloise T. M. , Ramos Dafnin L. S. , Dantas Domingos S. M. , Carbonell Roberto C. C. , Cerni Felipe A. , Pucca Manuela B.
Published: March 2024

Neurocysticercosis, a parasitic infection of the central nervous system (CNS), is a significant public health issue globally, including in Brazil. This article presents a case report of a 44-year-old male patient residing in the rural area of Roraima, the northernmost region of Brazil within the Amazon Forest. The patient, with chronic HIV infection, acquired the Taenia solium helminth, resulting in neurocysticercosis development. Remarkably, the diagnosis of neurocysticercosis was not initially apparent but emerged through meticulous analysis following a motorcycle accident. The absence of seizures, a common clinical manifestation, complicated the diagnostic process, making it an uncommon case of NCC, which may be related to co-infection. As the patient’s condition progressed, multiple complications arose, requiring additional medical attention and interventions. This case underscores the immense challenges faced by healthcare teams in managing neurocysticercosis effectively. It emphasizes the critical need for a comprehensive, multidisciplinary approach to provide optimal care for such complex cases. The study’s findings underscore the importance of raising awareness and implementing improved strategies for tackling neurocysticercosis, particularly in regions where it remains a prevalent concern.
Paraspinal Muscle Changes in Individuals with and without Chronic Low Back Pain over a 4-Month Period: A Longitudinal MRI Study
Authors: Anstruther Meagan , Sean Monica , Tétreault Pascal , Fortin Maryse
Published: March 2024

Background and Objectives: Previous research has shown associations between atrophy and fatty infiltration of the lumbar paraspinal musculature and low back pain (LBP). However, few studies have examined longitudinal changes in healthy controls and individuals with LBP without intervention. We aimed to investigate the natural variations in lumbar paraspinal musculature morphology and composition in this population over a 4-month period. Materials and Methods: Healthy controls and individuals with LBP were age- and sex-matched and completed several self-administered questionnaires. MRIs of L1–L5 were taken at baseline, 2 months, and 4 months to investigate cross-sectional area (CSA), along with DIXON fat and water images. A total of 29 participants had clear images for at least one level for all three time points. Means and standard deviations were calculated for the participant demographics. A two-way repeated measures ANOVA was performed to investigate CSA, fat signal fraction, and CSA asymmetry. Results: A total of 27 images at L3/L4, 28 images at L4/L5, and 15 images at L5/S1 were included in the final analysis. There were significant main effects of group for psoas CSA at the L3/L4 level (p = 0.02) and erector spinae (ES) CSA % asymmetry at the L3/L4 level (p < 0.001). There was a significant main effect of time for lumbar multifidus (LM) CSA % asymmetry at L4/L5 level (p = 0.03). Conclusions: This study provides insights into LM, ES, and psoas morphology in both healthy controls and affected individuals over a 4-month period without any intervention. Our findings suggest that psoas CSA at higher lumbar levels and CSA % asymmetry in general may be a better indicator of pathology and the development of pathology over time. Evaluating natural variations in paraspinal musculature over longer time frames may provide information on subtle changes in healthy controls and affected individuals and their potential role in chronic LBP.
Polyurethane Microstructures for 2′-Deoxycytidinic Acid Delivery: Preparation and Preliminary Characterization
Authors: Jeleriu Roxana Maria , Cavaloiu Bogdana , Onofrei Lidia Manuela , Borcan Florin , Albulescu Ramona Carmen , Puiu Maria
Published: March 2024

Background and Objectives: Nucleotide delivery has emerged as a noteworthy research trend in recent years because of its potential utility in addressing a range of genetic defects resulting in the presence of incorrect nucleotides. The primary goals of this research were to create and to characterize polyurethane microstructures, with the aim of utilizing them for nucleotide transport. Materials and Methods: Two samples were prepared using an aliphatic diisocyanate in reaction with a mixture of polyethylene glycol and polycaprolactone diol, where 2′-deoxycytidinic acid was used as the active agent and glycerol 1,2-diacetate was used as an enhancer of the aqueous solubility. The solubility, pH, size distribution, and surface charge of the samples were measured, and encapsulation efficacy and release, cell proliferation, and irritation tests on mouse skin were conducted. Results: The results showed almost neutral acidic–basic structures with a high heterogeneity, and a medium tendency to form clusters with non-cytotoxic and non-irritative potentials. Conclusions: Future research could explore the efficacy of this carrier in delivering other nucleotides, as well as investigating the long-term effects and safety of these microstructures in vivo.
Associations between Atopic Dermatitis and Behavior Difficulties in Children
Authors: Kisieliene Inga , Aukstuolyte Beatrice , Mainelis Antanas , Rudzevicienė Odilija , Bylaite-Bucinskiene Matilda , Wolenberg Andreas
Published: March 2024

Background and Objectives: There has been increasing evidence that atopic dermatitis (AD) is associated with behavioral difficulties (BDs). There is currently a lack of evidence of how the severity of the disease determines BDs and what additional factors may contribute to their manifestation. The aim is to determine what kind of BDs occur in children with AD compared to healthy children and to find out what additional factors may contribute to the development of BDs in AD patients. Materials and Methods: This is a cross-sectional, prospective study with the application of a risk assessment instrument for behavior difficulties (Child Behavior Checklist, CBCL 6/18) in pediatric patients with AD and healthy controls (6–17 years) between 1 January 2020 and 31 December 2022. For statistical comparison, mainly Wilcoxon–Mann–Whitney and Student’s t-test were used, considering a significance level of 5%. Results: This study included a total of 101 children: 48% with AD, 52% non-AD. The mean age was 10 ± 2.7 years for AD, and10.5 ± 3.1 years for the control patients. AD patients had higher internal behavior scale scores and T-scores (6.6 ± 6.4 vs. 9.6 ± 6.9 and 47.9 ± 9.5 vs. 52.3 ± 10.2, p = 0.01), anxiety/depression scale score and T-score (2.8 ± 2.7 vs. 4.3 ± 3.5 and 47.7 ± 8.4 vs. 52.5 ± 11, p = 0.02), and somatic problems scale score and T-score (2.1 ± 2.3 vs. 3.5 ± 3 and 47.6 ± 8.5 vs. 52.7 ± 10.9, p = 0.005). Patients with severe AD had sleep disturbance and itching scores higher than those with mild–moderate AD (5.4 ± 2.6 vs. 2.4 ± 2.2, p = 0.000 and 6.6 ± 2.4 vs. 4 ± 2.8, p = 0.001). The mean morning serum cortisol concentration was lower in AD patients compared to controls (252.91 ± 304.34 vs. 351.55 ± 126.09 nmol/L, p = 0.047). Conclusions: Children with AD present a higher risk of BDs than healthy controls. Patients with severe AD experience more sleep disturbances and a greater intensity of itching compared to mild–moderate AD. The occurrence of BDs was not related to serum cortisol levels. The cortisol level, severity, age, gender, duration of illness, intensity of pruritus, and sleep disturbance did not affect the development of BDs.
Disseminated Enterovirus Infection in a Patient Affected by Follicular Lymphoma Treated with Obinutuzumab: A Case Report and a Narrative Review of the Literature
Authors: Lupia Tommaso , Corcione Silvia , Staffilano Elena , Bosio Roberta , Curtoni Antonio , Busca Alessandro , De Rosa Francesco Giuseppe
Published: March 2024

Background and Objectives: the principal purpose of this literature review is to cluster adults with hematological malignancies after treatment or on maintenance with obinutuzumab who experienced disseminated EV infection to understand clinical characteristics and outcome of this rare condition in these patients. We report the first clinical case of a male affected by follicular lymphoma treated with immune-chemotherapy including obinutuzumab who was affected by disseminated EV infection with cardiovascular involvement. Materials and Methods: this narrative review summarizes all the research about disseminated EV infection in immunosuppressed adult patients treated with obinutuzumab from January 2000 to January 2024 using the Scale for the Assessment of Narrative Review Articles (SANRA) flow-chart. We performed a descriptive statistic using the standard statistical measures for quantitative data. Results: we included six studies, five case reports, and one case report with literature analysis. We collected a total of seven patients, all female, with disseminated EV infection. The most common signs and clinical presentations of EV infection were fever and encephalitis symptoms (N = 6, 85.7%), followed by hepatitis/acute liver failure (N = 5, 71.4%). Conclusions: onco-hematological patients who receive immune-chemotherapy with a combination of treatments which depress adaptative immunity, which includes the antiCD20 obinutuzumab, could be at higher risk of disseminated EV infection, including CNS and cardiac involvement.
Has Extracorporeal Gas Exchange Performance Reached Its Peak?
Authors: Mouzakis Foivos Leonidas , Kashefi Ali , Hima Flutura , Mottaghy Khosrow , Spillner Jan
Published: March 2024

Extracorporeal gas exchange therapies evolved considerably within the first three–four decades of their appearance, and have since reached a mature stage, where minor alterations and discrete fine-tuning might offer some incremental improvement. A different approach is introduced here, making use of modern, purely diffusive membrane materials, and taking advantage of the elevated concentration gradient ensuing from gas pressure buildup in the gas chamber of the oxygenator. An assortment of silicone membrane gas exchangers were tested in vitro as per a modified protocol in pursuance of assessing their gas exchange efficiency under both regular and high-pressure aeration conditions. The findings point to a stark performance gain when pressurization of the gas compartment is involved; a 40% rise above atmospheric pressure elevates oxygen transfer rate (OTR) by nearly 30%. Carbon dioxide transfer rate (CTR) does not benefit as much from this principle, yet it retains a competitive edge when higher gas flow/blood flow ratios are employed. Moreover, implementation of purely diffusive membranes warrants a bubble-free circulation. Further optimization of the introduced method ought to pave the way for in vivo animal trials, which in turn may potentially unveil new realms of gas exchange performance for therapies associated with extracorporeal circulation.
Improved Discharge Performance of AZ72-0.05La Alloy Anode via Refining Mg17Al12 Phase
Authors: Guo Junqing , Wang Bo , An Shizhong
Published: March 2024

The morphology of phases in magnesium alloys is vitally important for their performance. It is found that improved discharge performance is achieved in AZ72-0.05La alloy via a refining Mg17Al12 phase by means of hot rolling. Before rolling, as-cast AZ72-0.05La alloy has a relatively coarse and strip-like Mg17Al12 phase. After rolling, the Mg17Al12 phase becomes much finer, showing a granulated shape. Due to the refinement of the Mg17Al12 phase, the discharge voltage and energy density of an Mg-air battery with as-rolled AZ72-0.05La alloy as the anode increases by 6% and 3% under a discharge current density of 20 mA·cm−2 in a 3.5% NaCl solution, respectively. The corrosion rate of the as-rolled AZ72-0.05La alloy is slightly larger than the as-cast AZ72-0.05La alloy, but still much lower than as-cast AZ72 alloy. The as-rolled AZ72-0.05La alloy possesses a discharge voltage of 0.74 V and an energy density of 918 mWh·g−1 under a discharge current density of 20 mA·cm−2, and a relatively low corrosion rate of 0.51 mg·cm−2·h−1, demonstrating good overall discharge performance. This work provides a method for improving the discharge performance of Mg-air batteries.
Laser Remelting of Ductile Cast Iron to Achieve a Graphite-Free Surface Layer for Enabling a Manual High-Gloss Finish
Authors: Kreinest Laura , Schüssler Johannes , Özaydin Onur , Kochuthundil Subhash Sujith , Willenborg Edgar , Bührig-Polaczek Andreas
Published: March 2024

Laser remelting is being explored as a viable technique for obtaining a graphite-free, defect-free surface layer on cast iron EN GJS 400-15. The goal is to obtain a large remelted layer along with a low surface roughness to enable a subsequent manual high-gloss surface finish. The impact of the laser remelting process parameters is evaluated by using samples with three different cooling rates, resulting in different graphite microstructures. By utilizing four passes and a laser power of 300 W, the smallest roughness and largest remelting depth are achieved. The remelted layer is mostly devoid of graphite particles. Subsequent manual polishing is performed to evaluate the potential for achieving a high-gloss finish with a roughness of Sa < 0.05 µm. Laser remelting alone does not improve visual appearance or reduce roughness. However, after manual polishing, the roughness of the laser-remelted surfaces with Sa = 0.018 µm is one order of magnitude smaller than the manually polished initial state. Graphite removal during laser remelting therefore makes it possible to achieve a conventional and high-gloss polish, overcoming the previous limitations of GJS materials.
Different Heat-Exposure Temperatures on the Microstructure and Properties of Dissimilar GH4169/IC10 Superalloy Vacuum Electron Beam Welded Joint
Authors: Cai Hualin , Ma Zhixuan , Zhang Jiayi , Qi Liang , Hu Jinbing , Zhou Jiayi
Published: March 2024

Vacuum electron-beam welding (EBW) was used to join the precipitation-strengthened GH4169 superalloy and a new nickel-based superalloy IC10 to fabricate the turbine blade discs. In this study, a solid solution (1050 °C/2 h for GH4169 and 1150 °C/2 h for IC10) and different heat-exposure temperatures (650 °C, 750 °C, 950 °C and 1050 °C/200 h, respectively) were used to study the high-temperature tensile properties and microstructure evolution of welded joints; meanwhile, the formation and evolution of the second phases of the joints were analyzed. After EBW, the welded joint exhibited a typical nail morphology, and the fusion zone (FZ) consisted of columnar and cellular structures. During the solidification process of the molten pool, Mo elements are enriched in the dendrites and inter-dendrites, and that of Nb and Ti elements was enriched in the dendrites, which lead to forming a non-uniform distribution of Laves eutectic and MC carbides in the FZ. The microhardness of the FZ gradually increased during thermal exposure at 650 °C and reached 300–320 HV, and the γ′ and γ″ phases were gradually precipitated with size of about 50 nm. Meanwhile, the microhardness of the FZ decreased to 260–280 HV at 750 °C, and the higher temperature resulted in the coarsening of the γ″ phase (with a final size of about 100 nm) and the formation of the acicular δ-phase. At 950 °C and 1050 °C, the microhardness of FZ decreased sharply, reaching up to 170~190 HV and 160~180 HV, respectively. Moreover, the Laves eutectic and MC carbides are dissolved to a greater extent without the formation of γ″ and δ phases; as a result, the absent of γ″ and δ phases are attributed to the significant improvement of segregation at higher temperatures.
Resting Metabolic Rate and Substrate Utilization during Energy and Protein Availability in Male and Female Athletes
Authors: Abulmeaty Mahmoud M. A. , Almajwal Ali , Elsayed Mervat , Hassan Heba , Alsager Thamer , Aldossari Zaid
Published: March 2024

Active athletes frequently develop low energy (LEA) and protein availabilities (LPA) with consequent changes in the vital metabolic processes, especially resting metabolic rate (RMR) and substrate utilization. This study investigated the association of energy and protein intakes with RMR and substrate utilization in male and female athletes and those with LEA and LPA. Sixty athletes (35% female, 26.83 ± 7.12 y) were enrolled in this study. Anthropometric measurements and body composition analysis were reported to estimate fat-free mass (eFFM). Dietary intakes were recorded by two-day multiple-pass 24 h recall records and three-day food records and then analyzed by food processor software to calculate protein intake (PI) and energy intake (EI). Indirect calorimetry was used to measure RMR and percentages of substrate utilization. Activity–energy expenditure (AEE) was assessed by using an Actighrphy sensor for three days. Energy availability was calculated using the following formula (EA = EI − AEE/eFFM). The correlation of EI and PI with RMR and substrate utilization was tested with Pearson correlation. In the LEA group, both EI and PI correlated positively with RMR (r = 0.308, 0.355, respectively, p < 0.05). In addition, EI showed a positive correlation with the percentage of fat utilization. In the male and sufficient-PA groups, PI correlated positively with the RMR and negatively with the percentage of protein utilization. In conclusion, the percentage of LEA is markedly prevalent in our sample, with a higher prevalence among males. Athletes with LEA had lower fat utilization and lower RMR, while those with sufficient PA showed lower protein utilization with excessive PI. These findings may explain the metabolic responses in the cases of LEA and LPA.
Application of Clinical Blood Metabogram to Type 2 Diabetes Mellitus
Authors: Lokhov Petr G. , Balashova Elena E. , Trifonova Oxana P. , Maslov Dmitry L. , Shestakova Ekaterina A. , Shestakova Marina V. , Dedov Ivan I.
Published: March 2024

The clinical blood metabogram (CBM) was developed to match a tailored analysis of the blood metabolome to the time, cost, and reproducibility constraints of clinical laboratory testing. By analyzing the main blood metabolite groups, CBM offers clinically relevant information about the intake of low-molecular substances into the organism, humoral regulation, liver function, amino acid level, and the lipid and carbohydrate metabolism. The purpose of this work was to investigate the relevance of using the CBM in patients with diabetes mellitus. For this, a CBM was obtained for 18 healthy individuals, 12 individuals with prediabetes, and 64 individuals with type 2 diabetes mellitus, separated into groups according to fasting blood glucose and oral glucose tolerance tests. The results showed that the CBM reveals diabetes-associated metabolic alterations in the blood, including changes in the levels of carbohydrates, ketone bodies, eicosanoids, phospholipids, and amino acids, which are consistent with the scientific data available to date. The CBM enabled the separation of diabetic patients according to their metabolic metabotypes, providing both a general overview of their metabolic alterations and detailing their individual metabolic characteristics. It was concluded that the CBM is a precise and clinically applicable test for assessing an individual’s metabolic status in diabetes mellitus for diagnostic and treatment purposes.
Effect of Adding Apolipoprotein B Testing on the Prevalence of Dyslipidemia and Risk of Cardiovascular Disease in the Korean Adult Population
Authors: Choi Rihwa , Lee Sang Gon , Lee Eun Hee
Published: March 2024

Traditional lipid parameters—including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and non-HDL-C (calculated as TC minus HDL-C)—have long been used as indicators of cardiovascular disease (CVD) risk. The laboratory records of 9604 Korean adults who underwent traditional lipid panel tests (TC, TG, and HDL), as well as ApoB testing, were analyzed to evaluate the prevalence of dyslipidemia and high CVD risk (utilizing the NCEP ATP III criteria for traditional lipid panels and various ApoB test cutoffs recommended by international guidelines (145 mg/dL, 130 mg/dL, and 100 mg/dL)). The overall prevalence of dyslipidemia, as determined by traditional lipid panel criteria, was 27.4%. Utilizing the ApoB cutoffs of 145 mg/dL, 130 mg/dL, and 100 mg/dL resulted in prevalence figures of 5.3%, 11.0%, and 36.3%, respectively. The concordance in dyslipidemia classification between traditional lipid tests and ApoB at cutoffs of 145 mg/dL, 130 mg/dL, and 100 mg/dL was 78.4%, 81.3%, and 74.7%, respectively. Up to 17.5% of participants, based on an ApoB cutoff of ≥100 mg/dL, exhibited isolated high ApoB in the absence of traditional lipid test anomalies. Incorporating ApoB testing could enhance the identification of Koreans at high CVD risk.
Origin of the High Density of Oxygen Vacancies at the Back Channel of Back-Channel-Etched a-InGaZnO Thin-Film Transistors
Authors: Ge Shimin , Xiao Juncheng , Li Shan , Yuan Dong , Dong Yuhua , Zhang Shengdong
Published: March 2024

This study reveals the pronounced density of oxygen vacancies (Vo) at the back channel of back-channel-etched (BCE) a-InGaZnO (a-IGZO) thin-film transistors (TFTs) results from the sputtered deposition rather than the wet etching process of the source/drain metal, and they are distributed within approximately 25 nm of the back surface. Furthermore, the existence and distribution depth of the high density of Vo defects are verified by means of XPS spectra analyses. Then, the mechanism through which the above Vo defects lead to the instability of BCE a-IGZO TFTs is elucidated. Lastly, it is demonstrated that the device instability under high-humidity conditions and negative bias temperature illumination stress can be effectively alleviated by etching and thus removing the surface layer of the back channel, which contains the high density of Vo defects. In addition, this etch method does not cause a significant deterioration in the uniformity of electrical characteristics and is quite convenient to implement in practical fabrication processes. Thus, a novel and effective solution to the device instability of BCE a-IGZO TFTs is provided.
Multi-Step Mechanical and Thermal Homogenization for the Warpage Estimation of Silicon Wafers
Authors: Xiang Zhouyi , Chen Min , Deng Yonghui , Huang Songhua , Liu Sanli , Li Ji
Published: March 2024

In response to the increasing demand for high-performance capacitors, with a simultaneous emphasis on minimizing their physical size, a common practice involves etching deep vias and coating them with functional layers to enhance operational efficiency. However, these deep vias often cause warpages during the processing stage. This study focuses on the numerical modeling of wafer warpage that occurs during the deposition of three thin layers onto these vias. A multi-step mechanical and thermal homogenization approach is proposed to estimate the warpage of the silicon wafer. The efficiency and accuracy of this numerical homogenization strategy are validated by comparing detailed and homogenized models. The multi-step homogenization method yields more accurate results compared to the conventional direct homogenization method. Theoretical analysis is also conducted to predict the shape of the wafer warpage, and this study further explores the impact of via depth and substrate thickness.
An Investigation into the Effect of Length Scale of Reinforcement on the Cryogenic Response of a Mg/2wt.%CeO2 Composite
Authors: Gupta Shwetabh , Johanes Michael , Parande Gururaj , Gupta Manoj
Published: March 2024

The present study attempted for the first time an investigation on the effect of deep cryogenic treatment in liquid nitrogen (LN) on magnesium–cerium oxide (Mg/2wt.%CeO2) composites containing equal amounts of different length scales (micron and nanosize) cerium oxide (CeO2) particles. The disintegrated melt deposition method was used to synthesize Mg-2CeO2 micro- and nanocomposites, followed by hot extrusion as the secondary processing. Further liquid nitrogen treatment was performed at a cryogenic temperature of −196 °C. The combined effects of cryogenic treatment and reinforcement length scale on physical, mechanical, and thermal behaviors were studied. The results indicate that LN-treated micro- and nanocomposite samples exhibit, in common, a reduction in porosity, similar grain size, and a limited effect on the original texture of the matrix. However, microhardness, 0.2% Compressive Yield Strength (CYS), failure strain, and energy absorbed increased for both micro- and nanocomposite samples. Overall, results clearly indicate the capability of deep cryogenic treatment with LN to positively diversify the properties of both micro- and nanocomposite samples.
Janus Particles in Acoustofluidic Setup: The Interplay between Self-Propulsion and Acoustic Trapping
Authors: Benko Lisa Marie , Misko Vyacheslav R. , Baraban Larysa , Makarov Denys , Maisto Antonio , Malsche Wim De
Published: March 2024

Acoustic focusing of particle flow in microfluidics has been shown to be an efficient tool for particle separation for various chemical and biomedical applications. The mechanism behind the method is the selective effect of the acoustic radiation force on distinct particles. In this way, they can be selectively focused and separated. The technique can also be applied under stationary conditions, i.e., in the absence of fluid flows. In this study, the manipulation of self-propelled particles, such as Janus particles, in an acoustofluidic setup was investigated. In experiments with self-propelled Janus particles and passive beads, we explored the interplay between self-propulsion and the acoustic radiation force. Our results demonstrated unusual and potentially useful effects such as selective trapping, escape, and assisted escape in binary mixtures of active and passive particles. We also analyzed various aspects related to the behavior of Janus particles in acoustic traps in the presence and absence of flows.
Trace Elements in Pernik Sub-Bituminous Coals and Their Combustion Products Derived from the Republika Thermal Power Station, Bulgaria
Authors: Yossifova Mariana G. , Eskenazy Greta M. , Vassilev Stanislav V. , Dimitrova Dimitrina A.
Published: March 2024

The contents of 49 trace elements in sub-bituminous Pernik coals and their waste products from preparation and combustion processes were investigated. The studied coals have trace element contents higher than the respective Clarke values for brown coals and some of them may pose environmental concerns. The elements Li, Rb, Cs, Ba, Sc, Y, La, Ce, Nd, Sm, Eu, Er, Ga, Zr, Sn, V, Nb, Ta, W, F, Cu, Zn, In, Pb, Cr, Co, Ni, and Th in the feed coals have concentrations that exceed twice the Clarke values. Most element contents in bottom ash are enriched compared with those in feed coal. Some of the volatile elements are equal or significantly depleted including Sn, Mo, Sb, F, Bi, Cd, Ge, and Pb. Fly ash has higher contents of Ga, Zr, Hf, Sn, V, Nb, Mo, and F in comparison with bottom ash. Most elements have a significant positive correlation with ash yield, indicating their inorganic association. The mixed wastes (coal slurry, bottom ash, and fly ash) in the disposal pond are slightly depleted of most of the elements studied with the exclusion of Cl, Ba, and Br. The Pernik coals and their waste products are unpromising for the extraction of REY due to their low element contents.
Distribution of Copper, Iron, and Sulfur in Copper Concentrate Particles during Oxidation under Simulated Flash Smelting Conditions
Authors: Pérez-Tello Manuel , de la Paz-Ojeda Valeria , Parra-Sánchez Víctor R. , Araneda-Hernández Eugenia A. , Fernández-Sagredo Madrioly C. , Villagrán-Guerra Eduardo A.
Published: March 2024

The distribution of copper, iron, and sulfur during the oxidation of La Caridad copper concentrate particles under simulated flash smelting conditions was studied in a laboratory reactor. Six wet-sieved size fractions and the unsieved copper concentrate were oxidized at 1123 K and 40% and 70% O2 by volume in the process gas during the experiments. Samples of partially oxidized particles were collected at 0.2, 0.8, and 0.9 m from the point of entry and analyzed in a QEMSCAN® unit to determine the elemental composition within the population of particles. The distribution of the major elements during oxidation was strongly dependent upon the size and chemical composition of the initial particles. Overall, the copper content tended to increase and sulfur content decreased along the reactor length within all sizes. In contrast, the distribution of iron did not follow a general trend, as it was found to increase, decrease, or remain unchanged depending on the particle size. This finding may represent a key feature to further investigate the reaction path followed by particles during flash smelting, especially those associated with particle fragmentation. In general, the larger the particle size was, the larger the change in the content of the major elements within the particle population. Based on the experimental results, particles within a size fraction of <45 µm tended to follow a reaction path consisting of rapid melting followed by the collision and coalescence of reacting droplets during flight. In contrast, particles within the fraction of 45–53 µm tended to react individually. The oxidation behavior of the unsieved concentrate particles showed a combination of both reaction paths.
Reservoir Characterization of Alluvial Glutenite in the Guantao Formation, Bohai Bay Basin, East China
Authors: Li Qing , You Xuelian , Zhou Yuan , He Yu , Tang Renzhi , Li Jiangshan
Published: March 2024

Alluvial glutenite reservoirs have obviously stronger heterogeneous and more complex control factors than sandstone reservoirs. Taking the Binxian Uplift area in the Boahi Bay Basin as an example, the aim of this study is to clarify the characteristics and control factors of the alluvial glutenite reservoir quality and the influence of reservoir properties on hydrocarbon accumulation. Pore types in the study area mainly include residual intergranular pores, intergranular dissolved pores, intragranular dissolved pores, and mold pores. The residual intergranular pores and intergranular dissolved pores are the main pore types. Most samples have porosity greater than 15% and permeability is mainly concentrated between 50 mD and 500 mD. It is shown that lithology type, microfacies, and diagenesis have significant impact on the reservoir quality. The reservoir qualities of very fine sandstone and fine sandstone are better than those of conglomerate and gravel-bearing sandstone. Instead of grain size, sorting affects the alluvial glutenite reservoir quality significantly. Oil-bearing samples commonly have sorting coefficient less than 2 while non-oil-bearing samples have sorting coefficient larger than 2. There are significant differences in reservoir physical properties of different sedimentary microfacies. The stream flow in mid-alluvial fan (SFMA) and braided channels outside alluvial fans (BCOA) have relatively weaker compaction and better reservoir quality than the overflow sand body (OFSB) and debris-flow in proximal alluvial fan (DFPA). Calcite cementation, the main cement in the study area, commonly developed at the base of SFMA and BCOA and near the sandstone-mudrock contacts. The source of calcium carbonate for calcite cement mainly came from around mudstone. High calcite cement content commonly results in low porosity and permeability. Individual glutenite thickness is also an important influencing factor on reservoir quality. Reservoirs with large thickness (>4 m) have high porosity and permeability. Dissolution occurred in the reservoir, forming secondary dissolution pores and improving reservoir quality. The dissolution fluid for formation of secondary pores is mainly meteoric waters instead of organic acid. The reservoir property has an important influence on hydrocarbon accumulation. The lower limit of physical properties of an effective reservoir is a porosity of 27% and permeability of 225 mD. The findings of this study can be utilized to predict the reservoir quality of alluvial glutenite reservoirs effectively in the Bohai Bay Basin and other similar basins.
Biocatalytic Synthesis of Coumarin S-Glycosides: Towards Non-Cytotoxic Probes for Biomedical Imaging and Sensing
Authors: Burrini Nastassja , Pâris Arnaud , Collet Guillaume , Lafite Pierre , Daniellou Richard
Published: March 2024

This study unveils an innovative method for synthesizing coumarin S-glycosides, employing original biocatalysts able to graft diverse carbohydrate structures onto 7-mercapto-4-methyl-coumarin in one-pot reactions. The fluorescence properties of the generated thio-derivatives were assessed, providing valuable insights into their potential applications in biological imaging or sensing. In addition, the synthesized compounds exhibited no cytotoxicity across various human cell lines. This research presents a promising avenue for the development of coumarin S-glycosides, paving the way for their application in diverse biomedical research areas.
Recent Advances in Preparing Transparent Phosphor Ceramics for High-Index Color Rendering and High-Power Lighting
Authors: Du Boshen , Li Wanyuan , Zhang Lin , Chen Pei , Lu Fengniu
Published: March 2024

In recent years, high-power white light-emitting diode (wLED)/laser diode (wLD) lighting sources based on transparent phosphor ceramic (TPC) materials have attracted increasing application interest in automotive headlights, projection displays, and space navigation lighting due to their superior brightness, lighting distance, compactness, lifespan, and environmental resistance compared with the widely used phosphor-converted wLEDs. However, preparing TPC-converted wLEDs/wLDs with high color rendering index (CRI) remains a huge challenge, which limits their widespread application. In this review, we summarize the recently adopted strategies for constructing TPCs to develop high-power wLEDs/wLDs with high CRI values (>75). The construction protocols were categorized into four groups: host regulation, red-emitter doping, host regulation/red-emitter doping combination, and composite structure design. A comprehensive discussion was conducted on the design principles, photoluminescent properties, and device performances for each strategy. The challenges and future trends of high-power and high-CRI wLEDs/wLDs based on TPCs are also discussed toward the end of this review.
Ameliorative Effect of Areca Nut Polyphenols on Adverse Effects Induced by Lipopolysaccharides in RAW264.7 Cells
Authors: Zou Luyan , Yi Shuhan , Wang Yuanliang
Published: March 2024

In Asian regions, areca nuts are tropical fruits that are extensively consumed. The areca nut contains a lot of polyphenols and its safety is unknown. In this research, we investigated the effects of lipopolysaccharides (LPS) and areca nut polyphenols (ANP) on normal RAW264.7 cells. The results showed that LPS stimulated adverse effects in normal cells by affecting cytokine production. The GO analysis results mainly affected DNA repair, cell division, and enzyme activities. In the KEGG analysis results, the NOD-like receptor signaling pathway, which is related to NF-κB, MAPK, and the pro-inflammatory cytokines, is the most significant. In the protein–protein interaction network (PPI) results, significant sub-networks in all three groups were shown to be related to cytokine–cytokine receptor interaction. Collectively, our findings showed a comprehensive understanding of LPS-induced toxicity and the protective effects of ANP by RNA sequencing.
Synthesis of Alkenylgold(I) Complexes Relevant to Catalytic Carboxylative Cyclization of Unsaturated Amines and Alcohols
Authors: Hase Shun , Yamashita Kyohei , Kayaki Yoshihito
Published: March 2024

The carboxylation of unsaturated amine and alcohol compounds, including 4-benzylamino-1-phenyl-1-butyne (homopropargylamine), 2-butyne-1-ol (propargylic alcohol), and 2,3-butadiene-1-ol (allenylmethyl alcohol), using the hydroxidogold(I) complex, AuOH(IPr) [IPr = 1,3-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene], produces corresponding alkenylgold(I) complexes with a cyclic urethane or carbonate framework in high yields. The reaction takes place in aprotic THF at room temperature under the atmospheric pressure of CO2 in the absence of base additives. The products were characterized by NMR spectroscopy, elemental analysis, and X-ray crystallography. The functionalized alkenyl complexes prepared from the alkynes can be protonated by treatment with an equimolar amount of acetic acid to afford five- or six-membered carboxylation products, whereas the related alkenyl complex derived from allenylmethyl alcohol decomposed to recover the starting allene via ring-opening decarboxylation.
Novel Meta-Diamide Compounds Containing Sulfide Derivatives Were Designed and Synthesized as Potential Pesticides
Authors: Wu Jingwen , Dang Shuaihui , Zhang Yan , Zhou Sha
Published: March 2024

The meta-diamide (m-diamide) insecticide, Broflanilide, was characterized by its high efficiency, low toxicity and lack of cross-resistance with traditional GABA receptors. In accordance with the principles of drug molecular design, easily derivable sulfur with diverse bioactivities was introduced while leading with the parent Broflanilide. Twelve novel m-diamide target compounds containing sulfide derivatives were synthesized through exploration guided by the literature. Their structures were confirmed by melting points, 1H NMR, 13C NMR and HRMS. Insecticidal activity assessments revealed that most target compounds A–D exhibited 100% lethality against Plutella xylostella (P. xylostella) and Aphis craccivora Koch (A. craccivora) at 500 mg·L−1. Notably, for P. xylostella, compounds C-2, C-3, C-4 and D-2 demonstrated 60.00–100.00% insecticidal activity even at a concentration as low as 0.625 mg·L−1. As determined by structure–activity relationship (SAR) analysis, compounds with R1 = CH3 and R2 = Br (B-1, C-2 and D-2) and sulfoxide compound C-3 contained 100.00% lethality against A. craccivora at 500 mg·L−1, surpassing the lethality when leading with the parent Broflanilide in terms of efficacy. Consequently, it can be inferred that the sulfoxide compound (C-3) requires further investigation as a potential active molecule for new insecticides. These explorations provide valuable references for future research on the synthesis and insecticidal activities of sulfide-containing m-diamide compounds.
Molecular Insights into the Enhanced Activity and/or Thermostability of PET Hydrolase by D186 Mutations
Authors: Qu Zhi , Zhang Lin , Sun Yan
Published: March 2024

PETase exhibits a high degradation activity for polyethylene terephthalate (PET) plastic under moderate temperatures. However, the effect of non-active site residues in the second shell of PETase on the catalytic performance remains unclear. Herein, we proposed a crystal structure- and sequence-based strategy to identify the key non-active site residue. D186 in the second shell of PETase was found to be capable of modulating the enzyme activity and stability. The most active PETaseD186N improved both the activity and thermostability with an increase in Tm by 8.89 °C. The PET degradation product concentrations were 1.86 and 3.69 times higher than those obtained with PETaseWT at 30 and 40 °C, respectively. The most stable PETaseD186V showed an increase in Tm of 12.91 °C over PETaseWT. Molecular dynamics (MD) simulations revealed that the D186 mutations could elevate the substrate binding free energy and change substrate binding mode, and/or rigidify the flexible Loop 10, and lock Loop 10 and Helix 6 by hydrogen bonding, leading to the enhanced activity and/or thermostability of PETase variants. This work unraveled the contribution of the key second-shell residue in PETase in influencing the enzyme activity and stability, which would benefit in the rational design of efficient and thermostable PETase.
Quantification of Trimethylamine-N-Oxide and Trimethylamine in Fish Oils for Human Consumption
Authors: Dörfel Dominik , Rohn Sascha , Jantzen Eckard
Published: March 2024

Supplementing fish oil is one of the strategies to reduce the risk of cardiovascular disease, the leading cause of death around the world. Contradictorily, fish oil may also contain trimethylamine-N-oxide, a recently emerged risk factor for cardiovascular disease, as well as one of its precursors, trimethylamine. A method suitable for routine quantification of trimethylamine-N-oxide and trimethylamine in fish oil with a quick and easy liquid extraction without derivatization has been developed. Liquid chromatography with tandem mass spectrometry detection was employed along with a zwitterionic hydrophilic interaction liquid chromatography column and a gradient elution with eluents containing 50 mmol/L of ammonium formate. An internal standard (triethylamine) was used for quantification by mass spectrometry with an external calibration. The assay proved high linearity in the ranges of 10 to 100 ng/mL and 100 to 1000 ng/mL for trimethylamine-N-oxide and trimethylamine, respectively. The lowest limit of quantification was determined to be 100 µg/kg for trimethylamine and 10 µg/kg for trimethylamine-N-oxide, with the limit of detection at 5 µg/kg and 0.25 µg/kg, respectively. Accuracy ranged from 106–119%. Precision was below 7% the relative standard deviation for both analytes. The method was successfully applied for the determination of trimethylamine-N-oxide and trimethylamine contents in nine commercially available liquid fish oils and three commercially available fish oil capsules, showing that trimethylamine and trimethylamine-N-oxide are not present in highly refined fish oils.
Synthesis and Spectroscopic Characterization of Selected Water-Soluble Ligands Based on 1,10-Phenanthroline Core
Authors: Nycz Jacek E. , Martsinovich Natalia , Wantulok Jakub , Chen Tieqiao , Książek Maria , Kusz Joachim
Published: March 2024

Water-soluble ligands based on a 1,10-phenanthroline core are relatively poorly studied compounds. Developing efficient and convenient syntheses of them would result in new interesting applications because of the importance of 1,10-phenanthrolines. In this manuscript, we describe novel and practical ways to introduce a carboxyl and, for the first time, a phenol and dithiocarboxyl group under mild reaction conditions. This strategy enables highly efficient and practical synthesis of suitable organosulfur compounds with high added value, high chemoselectivity, and a broad substrate range. We present the selective conversion of a hydroxydialdehyde in the form of 10-hydroxybenzo[h]quinoline-7,9-dicarbaldehyde into its derivative, unique hydroxydicarboxylic acid, by an oxidation procedure, giving 10-hydroxybenzo[h]quinoline-7,9-dicarboxylic acid. A similar procedure resulted in the formation of 9-methyl-1,10-phenanthroline-2-carboxylic acid by oxidation of commercially available neocuproine. An alternative method of obtaining 1,10-phenanthroline derivatives possessing carboxylic acid group can be based on the hydrolysis of ester or nitrile groups; however, this synthesis leads to unexpected products. Moreover, we apply Perkin condensation to synthesize a vinyl (or styryl) analog of 1,10-phenanthroline derivatives with phenol function. This reaction also demonstrates a new, simple, and efficient strategy for converting methyl derivatives of 1,10-phenanthroline. We anticipate that the new way of converting methyl will find wide application in chemical synthesis.
Turn Waste Golden Tide into Treasure: Bio-Adsorbent Synthesis for CO2 Capture with K2FeO4 as Catalytic Oxidative Activator
Authors: Ying Huijuan , Jia Chenglin , Zeng Ganning , Ai Ning
Published: March 2024

Converting Sargassum horneri (SH)—a harmful marine stranding that can cause golden tide—to highly porous bio-adsorbent material (via one-step catalytic oxidative pyrolysis with K2FeO4) can be a strategically useful method for obtaining low-cost materials suitable for CO2 capture. In this manuscript, the behavior of different mass ratios of K2FeO4/SH precursor acting on the surface physicochemical properties of carbon materials are reported. The results suggest that specific surface area and total pore volume first increased to the mass ratio of K2FeO4/carbon precursor, then decreased. Among the samples prepared, the highest specific surface area was obtained with a K2FeO4/SH precursor ratio of 1:4 (25%-ASHC), and the CO2 adsorption performance was significantly increased and faster compared with the original biochar. The fitted values of the three kinetic models showed that the double exponential model provided the best description of carbon adsorption, indicating both physical and chemical adsorption; 25%-ASHC also exhibited excellent cyclic stability. The improved CO2 adsorption performance observed after K2FeO4 activation is mainly due to the increase in material porosity, specific surface area, and the enrichment of nitrogen and oxygen functional groups.
Comprehensive Review on Chiral Stationary Phases in Single-Column Simultaneous Chiral–Achiral HPLC Separation Methods
Authors: Papp Lajos Attila , Szabó Zoltán István , Hancu Gabriel , Farczádi Lénárd , Mircia Eleonora
Published: March 2024

This comprehensive review explores the utilization of chiral stationary phases (CSPs) in the context of single-column simultaneous chiral–achiral high-performance liquid chromatography (HPLC) separation methods. While CSPs have traditionally been pivotal for enantioselective drug analysis, contemporary CSPs often exhibit notable chemoselective properties. Consequently, there is a discernible trend towards the development of methodologies that enable simultaneous enantio- and chemoselective separations utilizing a single CSP-based chromatographic column. This review provides an exhaustive overview of reported HPLC methods in this domain, with a focus on four major CSP types: cyclodextrin-, glycopeptide antibiotic-, protein-, and polysaccharide-based CSPs. This article delves into the diverse applications of CSPs, encompassing various chromatographic modes such as normal phase (NP), reverse phase (RP), and polar organic (PO). This review critically discusses method development, emphasizing the additional chemoselective separation mechanisms of CSPs. It also explores possibilities for method optimization and development, concluding with future perspectives on this evolving field. Despite the inherent challenges in understanding the retention mechanisms involved in chemoselective separations, this review highlights promising trends and anticipates a growing number of simultaneous enantio- and chemoselective methods in pharmaceutical analyses, pharmacokinetic studies, and environmental sample determinations.