bluuebunny/crossref_metadata_2025 huggingface dataset:
Financial Analysis: A Study on the Liquidity and Indebtedness of Brazilian Companies Listed on the Bovespa Index in the Period of Social Isolation Caused by Covid-19
Authors: Pessanha Barreto Iury , Jardim de Araujo Saulo
Published: September 2021

The present work aimed to carry out a study on the variation of liquidity and indebtedness of companies listed on the Bovespa Index of B3, for the four quarters of 2020, a period in which the world economy went through instabilities and imbalances due to the pandemic of Covid-19. Financial management is essential for companies, as without it managers can make inefficient decisions, which can negatively impact the company and its finances. The absence of good financial management can cause negative impacts on the company, especially in times of crisis, such as the period of the first year of the COVID-19 pandemic. Therefore, for a business to have good results, it is necessary to create strategies to manage the company's finances, including periodic liquidity and indebtedness analysis. Thus, the Current Liquidity Ratio (ILC) and the Cash Ratio(CI) were used to determine the liquidity of companies and their transformations for the period analyzed. For indebtedness, we sought to analyze the Liabilities/Assets Index and the Third-Party Capital/Equity Index. Data were collected from the Standardized Financial Statements (DFP) and Quarterly Information (ITR) available on the B3 page. In the analysis of this work, companies from the financial sector were excluded due to the incompatibility of accounting standards and the methodology addressed in the work. It was verified in the results that, on average, companies underwent a substantial increase in liquidity in 2020, mainly in the second quarter, in which there was an average increase, among the companies analyzed, of 33.18% in the Cash ratio. The Industrial Goods, Oil, Gas and Biofuels and Public Utilities sector had the greatest increases in liquidity in the period. In terms of indebtedness, it could be seen that there was an increase in the participation of third-party capital, but less significant than the increase in liquidity of companies. This suggests that liquidity was financed by reallocation of company assets and policies aimed at exchanging the companies' current liabilities for non-current liabilities. It is concluded that in periods of uncertainty, such as the COVID-19 Pandemic, one of the priorities of companies is in fact to strengthen cash through asset reallocation, liability refinancing and contracting of credit lines.
Academic entrepreneurship -The applicability of doctoral and doctoral theses from Campos dos Goytacazes -RJ in the entrepreneurial market
Authors: Rayra Fonseca Ferreira Lorena , Batista Silva Chesil
Published: September 2021

Knowledge combined with innovation has been shown to be a driving factor for the growth and development of sustainable economic markets and, given the reality of the current scenario in Brazil in relation to social, political and economic aspects, see the high rate of unemployment and informal workers that they need emergency governmental support to survive, the importance of cooperative union between academic centers, scientific society, government and private initiative to induce public and institutional policy strategies that cause scientific, technological and social advances, transforming the knowledge in market innovations that generate jobs and income for social actors. In this scenario, stricto sensu postgraduate courses, especially doctorates, have contributed to the advancement of Innovation, Science and Technology, considered to be driversof economic and social change. Thus, assuming that all theses created in university centers precede an intellectual innovation, this research aims to highlight the reasons that lead to low entrepreneurial applicability among doctoral and doctoral student research. The hypothesis raised is that the lack of disciplines interconnected to entrepreneurship in graduate studies creates an imprisonment of Brazilian scientists' ideas in the academic field without other ramifications. The methodological procedures used will be of a qualitative quantitative approach, with regard to the objectives, the research is presented as descriptive and exploratory, having as a procedure bibliographic studies and the creation and application of a questionnaire for doctors and doctoral students in the city of Campos dos Goytacazes-RJ. As a result of this research, I hoped to understand the reasons that lead to the low applicability and insertion of academic ideas in local entrepreneurship and the statistical survey of alternatives for interconnection between researchers and the market.
Literature review to determine what is the degree of BIM maturity in University education Institutions of Architecture andUrbanism and Civil Engineering
Authors: Viveiros Machado Bruna , Vieira Azeredo de Sousa Laís , Maria Peixoto Chrispim Zélia , Salema Marques Portella Tatiana
Published: September 2021

The civil construction industry is constantly improving its processes, products and services. Part of this improvement has been the application of a new technology to building planning, namely Building Information Modeling (BIM), a technology aimed at information modeling in civil construction throughout the building's life cycle. The domain of BIM has become indispensable to every professional trained in architecture and urbanism and civil engineering, as it operates interoperability and collaboration between professionals, requiring training in various tools and software that are structured within this concept. However, the adoption and implementation of the use of technology in institutions is an expensive, paradigm-shifting and gradual process. The technology implementation stages started to receivethe nomenclature of “BIM maturity levels”, starting to be attributed in order to measure and monitor a successful implementation in the full reach of what the technology offers. This research aims to study and understand what the concept of BIM maturity level is in the construction industry, when applied to the Collegeenvironment. For this purpose, a literature review will be carried out based on bibliographic surveys, articles, seminars and congress proceedings, which will help to determine the steps andfactors that should be taken into account to assign BIM maturity levels to Collegeof Architecture and Urbanism and Civil Engineering. It is hoped that this will contribute to the understanding of the BIM maturity level inColleges, based on the main literature on the subject
CoronavirusPost Pandemic Professor
Authors: da Silva Caldas Júlia , da Silva Gomes Larissa , Pessanha Falcão Juliana , Alves de Carvalho Luzia
Published: September 2021

This research is inspired by the work developed by Sancho Gil E Hernández, Hernández (2016) in “Teachers in Uncertainty: learning teaching in today's world”, but differs substantially considering the context of structural change in the Teaching System and the sociological, psychological and philosophical coordinates of those involved. Its general objective is to understand the process of change of teachers (in the pandemic period –from March 2020 to March 2021), to reinvent themselves and become creative and technologically competent teachers to respond to the needs of children in remote education.This is a qualitative, exploratory, constructivist ethnographic research to be writtenwith data collected in the field sinceMarch 2020. Instruments such as participant observation, document analysis, individual and focus group interviews will be used.The subjects are eight Kindergarten and eight first year Elementary School teachers from Nossa Senhora Auxiliadora Educational Center -CENSA, Campos dos Goytacazes/RJ. It is hoped that the testimony and theirnew pedagogical practices are able toinspire other teachers to take a “new attitude towards” their students, even in the context of a pandemic
UniversityNeighborhood: an analysis of extension activities developed in the Tamarindo Community
Authors: da Silva Ferreira Francine , Claudina de Oliveira Cunha Teresa , Pessanha Falcão Juliana
Published: September 2021

The development ofthis work is based on the tripod: local and regional context; emphasis on academic and curricular mobility, which enables the integration of theory-practice, teaching-research-extension, achieving the necessary integration and synergy between the university and the community; and in the institutional commitmentand identity, promoting the construction of a strong institutional identity, with the clarity of its mission and the involvement of all institutional agents for the establishment of an organizational structure that acts in an organic and effective way. The mainobjective of this study and investigation will be to discuss the contribution of the social project of university extension “Universidade Bairro” (Neighborhood University) developed by ISECENSA in TamarindoCommunity, located in Campos dos Goytacazes, RJ, for the academic and professional trainingof students. The locusof the research will be the Tamarindo Community, located in the urban area of Campos dos Goytacazes, RJ. The population will be students enrolled in higher education courses at ISECENSA(2021/2022) who work in the development of extension actions and community residents.As for the approach to the problem, the study and investigation will have a qualitative approach. For data collection, multiple data sources will be used: bibliographic research, participatory observation, interviews and questionnaires.What is expected from this project is a reflection on the importance of socio-academic work for academic training, developing them, encouraging them, leading them to systematize and socialize reflections on practice in the various fields of activity.As well as contributing to the establishment of an Extension Policy for ISECENSA and to subsidizing the academic and institutional actions developed with the Tamarindo Community.
The psychosocial impacts of remote education on black youth: an intersectional debate on the COVID-19 pandemic, gender, race and class
Authors: Possoly da Silva Alves Daianne , Therezinha Magno Calidoni Franciele , Sales de Oliveira Mariana , Araújo de Azevedo Thaís , Bastos Batista Thalissa , Pinheiro de Almeida Neves Rafaela , Ribeiro de Andrade Edson
Published: September 2021

The Covid-19 pandemic has moved scientists from different areas of knowledge worldwide to bring reflections on the impacts caused by it, whose scope goes beyond human health in its physical and psychological aspects and affects the economy, politics, social relations at work, the educational system, etc. Therefore, this project, promoted by the Laboratory for the Study of Stigmatization Processes (LEPE) in partnership with the Racism Studies Line (LER) of the Psychology Course of the Higher Education Institutes at CENSA -ISECENSA, aims to promote the debate on the psychosocial effects of remote education on black youth, through an intersectional analysis between Covid-19 pandemic, gender, race and class. The objective of this research is to understand the ways in which black youth was affected in the psychosocial dimension with the establishment of remote education in the public state network with the Covid-19 pandemic. This is an exploratory research, in which a bibliographic review will be carried out to support the researchers' views on the proposed theme, using books and scientific articles on social psychology, remote education in the Covid-19 pandemic, racism and intersectionality. Besides field research, using the semi-structured interview technique. We intend to conduct group interviews, through Google Meet, with black students graduating from Liceu de Humanidades de Campos high school and from other public schools.. We hope to foster the discussion on structural racism that affects the Brazilian society focusing on the psychosocial vulnerability of black youth in the face of remote education established by the Covid-19 pandemic, and, finally, to publish two scientific articles in “Revista Perspectivas Online” with the obtained results
Team idea mapping method: A brainstorming session for enhancing problem-solving skills in postgraduate medical biochemistry students as assessed by self-efficacy
Authors: Goswami Binita , Mahajan Rajiv , Jain Anju , Koner Bidhan Chandra
Published: September 2021

Objectives:

The present study was conducted to evaluate the effect of Team Idea Mapping (TIM) sessions on the problem solving skills of postgraduate (PG) students of Biochemistry, as deduced from retro-pre self-efficacy questionnaire.

Materials and Methods:

The study was conducted enrolling students pursuing PG-MD course in Medical Biochemistry in a premier medical college. First TIM session was preceded by sensitization of PG students and departmental faculty. In total, four TIM sessions were conducted. Retro-pre self efficacy questionnaire was administered 3 months after the last session. Feedback from the students was collected immediately after last session and satisfaction index was also calculated.

Results:

The satisfaction index was highest (100) for items stating that TIM sessions promoted interactivity and participatory behaviorand lowest (78) for item stating that TIM sessions promoted reflective behavior respectively. The students expressed enhanced self-efficacy in understanding Biochemistry concepts, clinical application of Biochemistry, problem solving skills in Biochemistry, interpreting laboratory reports, participation in group works and clarifying problems with peers and seniors. However, the sessions were not as effective in instilling technical skills like trouble shooting for analyzer breakdowns.

Conclusion:

TIM is an effective tool for instilling problem solving skills in medical PG students, additionally fortifying their attitude to work in groups.
Charge-Transfer Selectivity and Quantum Interference in Real-Time Electron Dynamics: Gaining Insights from Time-Dependent Configuration Interaction Simulations
Authors: Ramakrishnan Raghunathan
Published: September 2021

Many-electron wavepacket dynamics based on time-dependent configuration interaction (TDCI) is a numerically rigorous approach to quantitatively model electron-transfer across molecular junctions. TDCI simulations of cyanobenzene thiolates---para- and meta-linked to an acceptor gold atom---show donor states conjugating with the benzene $\pi$-network to allow better through-molecule electron migration in the para isomer compared to the meta counterpart. For dynamics involving non-conjugating states, we find electron-injection to stem exclusively from distance-dependent non-resonant quantum mechanical tunneling, in which case the meta isomer exhibits better dynamics. Computed trend in donor-to-acceptor net-electron transfer through differently linked azulene bridges agrees with the trend seen in low-bias conductivity measurements. Disruption of $\pi$-conjugation has been shown to be the cause of diminished electron-injection through the 1,3-azulene, a pathological case for graph-based diagnosis of destructive quantum interference. Furthermore, we demonstrate quantum interference of many-electron wavefunctions to drive para- vs. meta- selectivity in the coherent evolution of superposed $\pi$(CN)- and $\sigma$(NC-C)-type wavepackets. Analyses reveal that in the para-linked benzene, $\sigma$ and $\pi$ MOs localized at the donor terminal are in-phase leading to constructive interference of electron density distribution while phase-flip of one of the MOs in the meta isomer results in destructive interference. These findings suggest that a priori detection of orbital phase-flip and quantum coherence conditions can aid in molecular device design strategies.
CO2-Mediated Pd-Catalyzed Stereo- and Regioselective Arylation of Free Allylamines
Authors: Landge Vinod , Maxwell Justin , Chand-Thakuri Pratibha , Kapoor Mohit , Diemler Evan , Young Michael
Published: September 2021

Mizoroki-Heck couplings are a powerful method for elaborating alkene feedstocks. While selective functionalization of terminal olefins has been achieved by catalyst design, selective functionalization of internal olefins has generally required use of directing groups except in the case of Michael acceptors. Allylamine substrates have typically required protection to be suitable for these reactions, decreasing the step and atom economy of these procedures. Herein we demonstrate that the addition of CO2 (dry ice) allows for the reproducible stereospecific arylation of both secondary and primary allylamines in the presence of a PdII catalyst. Notably, the product 3,3’-diarylallylamine motif is prevalent in a variety of biologically-relevant structures, and this method represents the most straightforward synthesis of these targets to date. Key features of the method are the ability to access relatively mild conditions that facilitate a broad substrate scope, as well as direct diarylation of terminal allylamine substrates. In addition, several complex and therapeutically-relevant molecules are included to demonstrate the utility of the transformation. Mechanistic studies point to an amine-directed reaction where CO2 serves to protect the substrate and product from degradation.
Colloidal HgTe Quantum Dot/Graphene Phototransistor with a Spectral Sensitivity Beyond 3 µm
Authors: Grotevent Matthias , Hail Claudio U. , Yakunin Sergii , Bachmann Dominik , Calame Michel , Poulikakos Dimos , Kovalenko Maksym V. , Shorubalko Ivan
Published: September 2021

Infrared light detection enables diverse technologies ranging from night vision to gas analysis. Emerging technologies such as low-cost cameras for self-driving cars require highly sensitive, low-cost photodetector cameras with spectral sensitivities up to wavelength of 10 um. For this purpose, colloidal quantum dot (QD) graphene phototransistors offer a viable alternative to traditional technologies owing to inexpensive synthesis and processing of QDs. However, the spectral range of these phototransistors have been thus far limited to 1.6 um. Here, we present HgTe QD/graphene phototransistors with spectral sensitivities up to 3 um, with specific detectivities of 6x108 Jones at a wavelength of 2.5 um and a temperature of 80 K. Even at kHz light modulation frequencies, specific detectivities exceed 108 Jones making them suitable for fast video imaging. The simple device architecture and QD film patterning in combination with a broad spectral sensitivity manifest an important step towards low-cost, multi-color infrared cameras.
Density-driven correlations in many-electron ensembles: theory and application for excited states
Authors: Gould Tim , Pittalis Stefano
Published: September 2021

Density functional theory can be extended to excited states by means of a unified variational approach for passive state ensembles. This extension overcomes the restriction of the typical density functional approach to ground states, and offers useful formal and demonstrated practical benefits. The correlation energy functional in the generalized case acquires higher complexity than its ground state counterpart, however. Little is known about its internal structure nor how to effectively approximate it in general. Here we show that such a functional can be broken down into natural components, including what we call ``state-'' and ``density-driven'' correlations, with the former amenable to conventional approximations, and the latter being a unique feature of ensembles. Such a decomposition, summarised in eq.(6), provides us with a pathway to general approximations that are able to routinely handle low-lying excited states. The importance of density-driven correlations is demonstrated, an approximation for them is introduced and shown to be useful.
New Supercoiling Theory and Model of Chromosomal Structures in Eukaryotic Cells
Authors: Zhang Hao , Li Tianhu
Published: September 2021

About six billion base pairs of DNA reside highly orderly in each human cell’s nucleus through their manifestation as twenty-three pairs of chromosomes. Delicate patterns of spatial organizations of DNA macromolecules in these eukaryotic chromosomes as well as their associated driving forces have, however, not been fully understood thus far. On the basis of (1) our four recent discoveries about supercoiling properties of histone H1, nucleosomes, linker DNA and polynucleosomes, (2) well-established axioms about sign, shapes and handedness of DNA supercoils, as well as (3) the fact that alterations of DNA supercoils are affiliated with every single steps of cellular genetic events, we analyze effects of DNA supercoils on eukaryotic chromosomal structures in systematical and comprehensive manners in the current report, and present new theory and models of eukaryotic chromosomal structures from the DNA supercoiling perspective. It is our hope that our current presentation of new supercoiling theory and models could provoke future new efforts to unravel exquisite eukaryotic chromosomal architectures in an all-inclusive manner.
Combining Ultra-High Drug Loaded Micelles and Shear Thinning, Injectable Hydrogel Drug Depots for Prolonged Drug Release
Authors: Lübtow Michael M , Lorson Thomas , Finger Tamara , Gröber-Becker Florian-Kai , Luxenhofer Robert
Published: September 2021

Hydrogel based drug depot formulations are of great interest for therapeutic applications. Here, the impact of incorporated drug, neat polymer micelles, and drug-loaded micelles on the viscoelastic properties of a cytocompatible hydrogel was investigated systematically. To challenge the hydrogel with regard to the desired application as injectable drug depot, curcumin (CUR) was chosen as a model compound due to its very low-water solubility and limited stability. CUR was either directly solubilized by the hydrogel or pre-incorporated into polymer micelles. Drug-release from a collagen matrix was studied in a trans-well setup and extended drug release over 10 weeks.
Assessing Negative Thermal Expansion in Mesoporous Metal-Organic Frameworks by Molecular Simulation
Authors: Evans Jack D. , Dürholt Johannes P. , Kaskel Stefan , Schmid Rochus
Published: September 2021

Most conventional materials display expansion upon heating, so there is considerable interest in identifying materials that display the opposite behavior, negative thermal expansion (NTE). In the current study, seven mesoporous metal-organic frameworks (MOFs) of varying topology and composition, which exhibit outstanding porosity, were investigated using molecular simulation for temperature-induced contraction. We find exceptional NTE for the most porous MOFs and a correlation between the coefficient of NTE and porosity. The large molecular subunits of the MOFs were further studied to find they intrinsically display NTE, corresponding to terahertz vibrational modes. As a result, NTE has a considerable effect on the mechanical properties of these MOFs and is an important consideration for understanding the mechanical stability of new extremely porous materials.
Vanadium-Catalyzed Oxidation of Terminal Olefin with Molecular Oxygen: Competing Products between Epoxide and Aldehyde
Authors: martoprawiro muhamad abdulkadir , Yulistiana Risma , Permana Yessi , arifin  , Irle Stephan
Published: September 2021

This work may give an understanding of why epoxide and aldehyde are easily generated in olefin oxidation by molecular oxygen when vanadium phenoxyimine complex was employed as a catalyst. This work would also explain why oxetane and dioxetane were harder to produce, although a radical tautomerism may allow the formation of such products.
Diagnostic and conservative treatment nuances in patients with obstructive jaundice: in the wake of Russian consensus
Authors: Khatkov I. E. , Avanesyan R. G. , Akhaladze G. G. , Beburishvili A. G. , Bulanov A. Yu. , Bykov M. I. , Vinnitskaia E. V. , Virshke E. R. , Gabriel S. A. , Granov D. A. , Darvin V. V. , Dolgushin B. I. , Dyuzheva T. G. , Efanov M. G. , Korobka V. L. , Korolev M. P. , Kulabukhov V. V. , Maystrenko N. A. , Melekhina O. V. , Nedoluzhko I. Yu. , Okhotnikov O. I. , Pogrebnyakov V. Yu. , Polikarpov A. A. , Prudkov M. I. , Ratnikov V. A. , Solodinina E. N. , Stepanova Yu. A. , Subbotin V. V. , Fedorov E. D. , Shabunin A. V. , Shapovalyants S. G. , Shulutko A. M. , Shishin K. V. , Tsvirkun V. V. , Chzhao A. V. , Kulezneva Yu. V.
Published: September 2021

The research was performed at the Loginov Moscow Clinical Scientific Center. It is based on Russian obstructive jaundice (OJ) consensus results, considered at the 45th annual Central Research Institute of Gastroenterology Scientific session Oncological issues in the gastroenterologist practice (1 March 2019). The article objective is to note the diagnostic and conservative treatment current issues in patients with OJ. The increase in the number of patients with OJ of different etiology provides problem actuality. In a large number of cases, medical treatment is delayed due to inadequate diagnostic and management, while correct patients routing today can be provided regardless of medical institution level. In this article the examination steps and conservative treatment role in patients with biliary obstruction management are presented.
Nifedipine Oral Disintegration Tablet: Design, Optimization, Invivo-pharmacokinetic and Stability Studies
Authors: Arindam Chatterjee  , Shaik Mohammad Abdulla  , Nagarajan G  , Birendra Shrivastava
Published: September 2021

Nifedipine has a bioavailability of 45-56 percent and a 2-hour elimination half-life. It has a 50 percent kidney excretion rate and a 5-15 percent bile excretion rate. The intention of this research is to invent and evaluate Nifedipine loaded ODT and to prove the enhancement of bioavailability. The 23 factorial optimization design exposed about the outcome of independent variable on dependent variable throughout the formulation of Nifedipine ODT. From the records, it was accomplished that there was a good correlation between Disintegration time, Dissolution rate and super disintegration concentration. The formulation F4 (Nifedipine ODT) has achieve the goal of ODT drug delivery with desired release characteristics, cost-effective, decreased dose, effective administration and hence improved patient compliance. The invivo pharmacokinetic studies reveals that increase in AUC0-∞; decrease in Tmax; increase in Cmax in Nifedipine ODT shows better bioavailability and faster duration of therapeutic action than marketed Nifilat® dosage form. Nifedipine ODT was stable at various temperature, humidity conditions and there was no drastic change in evaluation parameters. That it was concluded that Oral dispersible tablet (ODT) was a suitable dosage form to enhance the solubility at the same time the bioavailability of BCS class II drugs like Nifedipine.
OrtSuite: from genomes to prediction of microbial interactions within targeted ecosystem processes
Authors: Saraiva João Pedro , Bartholomäus Alexandre , Kallies René , Gomes Marta , Bicalho Marcos , Coelho Kasmanas Jonas , Vogt Carsten , Chatzinotas Antonis , Stadler Peter , Dias Oscar , Nunes da Rocha Ulisses
Published: September 2021

The high complexity found in microbial communities makes the identification of microbial interactions challenging. To address this challenge, we present OrtSuite, a flexible workflow to predict putative microbial interactions based on genomic content of microbial communities and targeted to specific ecosystem processes. The pipeline is composed of three user-friendly bash commands. OrtSuite combines ortholog clustering with genome annotation strategies limited to user-defined sets of functions allowing for hypothesis-driven data analysis such as assessing microbial interactions in specific ecosystems. OrtSuite matched, on average, 96% of experimentally verified KEGG orthologs involved in benzoate degradation in a known group of benzoate degraders. We evaluated the identification of putative synergistic species interactions using the sequenced genomes of an independent study that had previously proposed potential species interactions in benzoate degradation. OrtSuite is an easy-to-use workflow that allows for rapid functional annotation based on a user-curated database and can easily be extended to ecosystem processes where connections between genes and reactions are known. OrtSuite is an open-source software available at https://github.com/mdsufz/OrtSuite.
Recombinant Antimicrobial Peptide Fusion Between Crotalicidin Fragment Tag and Bacteriophage Endolysin T5 as a Potential Antibacterial Agent Against Multidrug Resistant Gram-Negative Bacteria: A Research Protocol
Authors: Huynh Alex , Dhillon Dalraj , Bhatt Dhairya , Zhang Eric
Published: September 2021

Introduction: Endolysins, antimicrobial peptides that disrupt the peptidoglycan (PG) layer of bacteria, are a strong alternative to common antibiotics and less prone to antibiotic resistance. However, endolysins are ineffective against gram-negative bacteria due to an additional outer membrane (OM) blocking the PG layer. This research protocol aims to address this caveat by developing a novel recombinant endolysin peptide, EndoT5-Ctn (15-34), comprised of phage Endolysin T5 and a Crotalicidin tag (Ctn (15-34)) capable of permeabilizing the OM. This would render the endolysin effective against gram-negative bacteria such as multidrug-resistant (MDR) Pseudomonas aeruginosa.
Methods: Experimentation will begin with recombinant DNA techniques to engineer a bacterial vector which expresses the EndoT5-Ctn (15-34) peptide. Protein expression will be achieved in competent BL21 (DE3) E. coli strains before protein isolation with lysis methods and immobilized-metal affinity chromatography. Resulting sample concentrations will be assayed using spectrophotometry. Finally, in vivo minimal inhibitory and bactericidal concentration assays will be conducted on MDR P. aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) to evaluate bactericidal efficacy.
Results: A minimal bactericidal concentration of EndoT5-Ctn (15-34) recombinant endolysin is expected to yield significant bactericidal activity against the MDR P. aeruginosa strain with limited effect on the gram-positive MRSA. A higher concentration of recombinant endolysin is expected to maintain its gram-negative bactericidal efficacy with an imported gram-positive bactericidal efficacy.
Discussion: The observed bactericidal efficacy on AMR and non-AMR strains on P. aeruginosa will prompt further exploration of the therapeutic feasibility of this therapy regarding factors such as cytotoxicity, immunogenicity, and thermal stability. The potential introduction of recombinant endolysins presents an alternative treatment for infections with reduced risk of inducing resistant mutations.
Conclusion: The EndoT5-Ctn (15-34) recombinant endolysin is a novel anti-bacterial agent which is expected to have significant bactericidal effects on MDR strains of gram-negative bacteria which current antibiotics have been ineffective at combating.
Tailored to Shrink
Authors:   , Kuruppuarachchi Nayanathara
Published: September 2021

Many of the materials currently used within the fashion industry are petroleum-based synthetics. These are not sustainable and do not use environmentally friendly production processes. Interest in sustainably produced fabrics is increasing, but more radical approaches are also being explored, such as “growing” fabric and materials from mycelium. In haute couture fashion, the experimental use of 3D printing is being investigated using synthetic materials. However, there is an opportunity to combine the organic growth of natural materials with the precision of digital control within 3D printing.

In response to this opportunity, this research investigates the design and creation of haute couture 3D printed garments, using an eco-friendly, semi-liquid bio-composite material developed for syringe printing utilising the precision of a robotic arm. It adopts a cross-disciplinary approach to the field, oscillating between Industrial Design and Fashion Design with some experiments broadly based on science methodologies.

Prospective biomaterials were identified and an iterative process of testing combinations of suitable growing mediums, fabric substrates, and fungal cultures were explored to assess growth, material properties, and design opportunities. Mycelium from a native New Zealand fungus was selected and a series of 2D printed patterns were developed based on the Material Driven Design Method (MDD), to understand the relationship between digital placement, fabric substrate, and mycelium growth. Contraction of the flat fabric during the drying process allowed the authorship of undulating 3D fabric. Using a range of parametric software, strategies for 3D form creation to fit the body through controlled shrinkage were developed. A final series of 3D haute couture garments were co-created through the symbiotic relationship of digital control and natural processes.

Key words: parametric fashion, 4D printing, natural shrinkage, sustainable fashion, bio-based 3D printing
Towards co-creation: A design-led study of ecological shifts in the tidal margin.
Authors:   , Hall Celia
Published: September 2021

The ecological resilience of the intertidal margins of many cities is increasingly under pressure due to climatic shifts and urbanisation. As rising sea levels push the high-water mark landward, many coastal species are prevented from migrating inland due to natural or man-made barriers. This results in a phenomena known as ‘coastal squeeze’.

Pauatahanui Inlet, Porirua supports a diverse ecosystem of aqua-fauna, micro invertebrates and wading birds that rely on the shallow saltmarsh habitat within the estuary. However, with sedimentation from the surrounding catchments slowly filling up the inlet along with and predicted tidal inundation from sea level rise, the future of this coastline is uncertain.

Rather than attempting to solve or secure a fixed future for the coastline, as is the prevailing anthropocentric response, this design led research seeks to respond to these human induced pressures by working with the cyclical phenological processes and ecological interactions occurring within the harbour. The research ambition is to co-create a shared public tidal realm.

This objective is tested through the design of a coastal boardwalk for the Pauatahanui Inlet. Unlike human-focused boardwalks, this infrastructure is designed with the capacity to adapt as the tidal edge shifts, in either direction, while facilitating movement for all forms of life to traverse the harbour. The research attempts to surpass perceived barriers between nature and culture with an emergent inquiry into the poetic nature of the site itself. Here landscape design practice is developed towards the creation of social capital as occurring between species, while ensuring the natural ecosystem (and the life it supports) has the capacity to adapt to potential climate related changes.
Indirect revascularization in patients, suffering critical ischemia of the lower extremities on background of diabetes mellitus
Authors: Ivanova Yu. V. , Kryvoruchko I. A. , Prasol V. A. , Miasoiedov K. V. , Andreieshchev S. A.
Published: September 2021

Objective. Determination of clinical efficacy of the mesenchymal stem cells transplantation in patients, suffering critical ischemia of the lower extremities on background of diabetes mellitus.
Materials and methods. There were examined 11 patients, suffering critical ischemia of the lower extremities on background of diabetes mellitus Type II with purulent-necrotic processes of the foot, in whom conditions for the direct revascularization of extremity were absent. Microbiological monitoring for the wound discharge, determination of the ankle brachial index and transcutaneous oximetry was performed. The technology elaborated have consisted of two stages. On the first of them a purulent focus sanation (in all the patients the distal amputations of the foot, preserving arterial arch) was done. On the second stage the therapy of the wounds was conducted, using negative pressure, injections of cellular suspension (mesenchymal stem cells) while applying long fine cannula under aponeurosis into the muscles along obliterated vessels in the (10 ± 5) ml quantity with subsequent closure of the wound surface, using fibroblastic matrix.
Results. In a year after the treatment critical ischemia in 1 patient was noted, the ischemia Grade III - in 3, and in 7 a IIB Grade have persisted.
Conclusion. Performance of indirect revascularization, using autologous mesenchymal stem cells, constitutes an effective and secure procedure.
Possibilities of the indocyanine green dye application for evaluation of peculiarities of lymph outflow and metastasizing of colorectal cancer
Authors: Grubnik V. V. , Nikitenko R. P. , Mishchenko V. V. , Ilyashenko V. V. , Degtyarenko S. P. , Parfentiev R. S. , Kvasha A. N.
Published: September 2021

Objective. Studying of velocity of prevalence of luminescent dye indocyanine green along lymphatic vessels in the large bowel surgery.

Materials and methods. Estimation of procedure for coloring of tumoral substrate and lymphatic vessels while performance of oncological operations was conducted. We performed laparoscopic resection of sigmoid colon in 7 patients, suffering tumors, and anterior rectal resection in 5 patients, having tumors of upper ampullary part of rectum, using indocyanine green dye.

Results. In Group I, consisting of 7 patients, surgical technique of no touch manipulations on the tumor before transection of feeding vessels (NTIT–operations) was applied, and in Group II, consisting of 5 patients, the tumor mobilization was done primarily. Application of indocyanine green dye helped a lot to establish localization and prevalence of the process in rectum.

Conclusion. Application of fluorescent dye indocyanine green on tumoral substrate before doing ligation of feeding vessels raises possibility of the complication occurrence, consisting of the cancer cells dissemination in abdominal cavity. While performing laparoscopic procedures in resection of the large bowel tumors it is expedient to ligate the feeding vessels primarily, with secondary manipulation– to dissect and mobilize the tumoral substrate.
Prognostic role of levels of extracellular histones H3 for diagnosis of early dysfunction of transplant after hepatic transplantation
Authors: Novruzov N. G.
Published: September 2021

Objective. The aim of this study was to determine the prognostic role of extracellular histones in the diagnosis of early graft dysfunction after liver transplantation..

Materials and methods. The 93 recipients undergoing LDLT were enrolled in this prospective study. Blood samples of patients were collected on postoperative day 1 and histone levels in the plasma samples were measured with Total Histone H3 sandwich ELISA kits. 19 (20.4%) subjects had early graft dysfunction (EAD) which was diagnosed on postoperative day 7 according to Ol-thoff’s criteria, based on liver function tests and coagulation profiles. Other 74 (79.6%) recipients did not have EGD.

Results. Levels of circulating histones were depressed in patients with EGD (0,808±0.026, 95% (CI) 0.752-0.864) than in patients without EGD (0.820±0.017, 95% (CI) 0.786-0.854) (P=0.727). These differences were not significant. The sources of histones in the circulation are not etiologies specific and levels of total histone H 3 after 24 h of operation had not stronger predictive value with AUC 0.477 (95 % CI 0.329 to 0.625) for liver dysfunction. The AUC value of the total bilirubin (AUC 0.685, 95 % CI 0.546 to 0.825) in predicting early graft dysfunction outperformed other LFTs and was less than CRP (AUC 0.705, CI 0.573 to 0.838).

The optimal cutoff value of total bilirubin obtained from the analysis of ROC curves was 4,5 and surpassed all other parameters with a sensitivity of 94.4% and a specificity of 40.7% respectively for prognoses of EGD (P=0.012). The univariate analysis determined that postoperative neutrophils level and CRP were identified as independent risk factors for early graft dysfunction. Neutrophils had a higher predictive value for liver dysfunction than any other parameter within 24 h (Odds ratio (OR) 16.3; 95% CI: 1.7-156.3, P = 0.016).  

Conclusion. Collectively, extracellular histone H3 levels were depressed, total bilirubin and CRP levels were elevated in patients with EGD, which can be used as early predictors for liver tissue damage and early allograft dysfunction in patients after liver transplantation.
Сучасний стан деревного розсадництва на території Волинської області
Authors: Shepeliuk Mariia , Andreieva Valentyna , Kychyliuk Oleksandr
Published: September 2021

Саджанці дерев та чагарників є основою багатьох наземних екосистем і є критично важ-ливим фактором та інвестицією для впровадження глобальних програм відновлення лісів і ландшафтів. Природна регенерація задовольняє лише частину цієї потреби, тому потрібна велика кількість високоякі-сного садивного матеріалу з різних типів розсадників.У статті проаналізовано особливості розміщення державних (лісових) та приватних розсадників на території Волинської області, а також їхні площі. Охарактеризовано та систематизовано асортимент ос-новних деревних розсадників. Встановлено, що загальна площа постійних державних лісових розсадників становить 58,4 га, а найбільший розсадник розташований на території ДП «Ратнівське лісомисливське господарство» – 36 га. Найбільш репрезентований асортимент деревних видів у ДП «Волинський лісовий селекційно-насіннєвий центр», що включає 27 родин, 44 роди та 67 видів. Серед приватних розсадників найбільшим асортиментом та площею (понад 100 га) охарактеризувався розсадник «Кліома Сервіс». Кі-лькість представлених таксонів становить 468 шт., з яких 344 – плодові види. Лідируючі позиції з вирощу-вання декоративних деревних рослин займають «Смарагд НВ» та «Лілі-Лайн» (Сад-Город).Зроблено висновки щодо сучасного стану та наведено рекомендації шляхів покращення і розвитку деревних розсадників на території Волинської області.
Екологічна роль біопереходів на трасі Н-31 у Дніпропетровській області
Authors: Hristov Oleg , Zadorozhna Galina , Trifanova Maria , Ponomarenko Alexander
Published: September 2021

На ділянці новозбудованої автомобільної дороги державного значення Н-31 у Дніпропет-ровській області проведено комплекс досліджень стосовно використання тваринами штучних споруд для перетину дороги та визначення їх ефективності. Всі досліджені біопереходи розташовані в трансформованій людиною частині ландшафту, в місцях з високою щільністю населення, віддаленістю екосистем з високими захисними властивостями, та використовуються дикими тваринами не ефективно. Водоводи (водопропускні споруди) мають більш вдале розташування та використовуються тваринами частіше, ніж біопереходи. Вони розташовані в пониззях рельєфу, що є більш екологічно вдалим. Водоводи використовуються тими ж ви-дами тварин середнього та дрібного розміру, що й біопереходи, але кількість перетинів тут відчутно більша. Наявність природного субстрату (ґрунту) безпосередньо в біопереході та деревно-чагарникової рослинності біля входу підвищує ефективність використання їх тваринами якісно та кількісно.За результатами власних досліджень та аналізу літератури надані загальні рекомендації для плану-вання розташування та структури цих споруд.
CPTED de Tercera Generación. Diagnóstico de Percepción Infantil la "Nube de los Sueños"
Authors: Rau Vargas Macarena
Published: September 2021

El artículo describe el contexto del crimen y la violencia en la América Hispana el año 2020 y 2021, así como la implementación de la metodología CPTED tanto de primera, segunda y tercera generación, enfocándose en una herramienta diagnóstica CPTED conocida en la América Hispana cómo la Nube de los Sueños que es participativa y le da voz tanto a niños como a niñas en la Región de la Latinoamérica y el Caribe respecto a sus preferencias y necesidades ambientales y posibilidades de intervención urbana. Por otro lado, se enfatiza la relevancia de la participación comunitaria en el ciclo de proyectos de CPTED de acuerdo a los planteado en la nueva ISO CPTED Standard 22341:2021. También se describe también la estructura del taller de la Nube de los Sueños CPTED, sus principales hitos históricos desde su inicio en el año 2006 hasta nuestros días y los tipos de información que se obtienen de su aplicación. Por último, se concluye vinculando la Nube de los Sueños con la tercera generación de la metodología CPTED que recién esta iniciando desde el año 2019.
Los sistemas de vídeovigilancia para prevenir la delincuencia. Lecciones aprendidas
Authors: Guido Nobili Gian
Published: September 2021

Durante las últimas tres décadas, las inversiones en sistemas de vídeovigilancia para la prevención de la criminalidad se han disparado a escala mundial. El rápido despliegue de esta tecnología hizo que se cometieran numerosos errores, a menudo, las lecciones sobre lo que podía o no lograrse con la vídeovigilancia se han aprendido con lentitud. La experiencia adquirida en los ultimos años nos permite extraer lecciones útiles, y contribuir así a mejorar significativamente el proceso de transferencia de políticas de seguridad ciudadana basadas en la evidencia, evitar errores, desarrollar mejores prácticas, aclarar puntos problemáticos e incluso ahorrar dinero. Se confirma que las instalaciónes de sistemas de vídeovigilancia posiblemente eficaces tienen que apoyarse en la acreditación de unos principios de reducción del crimen teóricamente sólidos que sugirien mecanismos causales plausibles a partir de los cuales los sistemas de vídeovigilancia puedan acometer el problema de delincuencia o desorden planteado en el contexto actual. En este sentido, la videovigilancia no se pone como una estrategia de prevención que se puede utilizar de manera indiscriminada y extensa. Solo es una medida útil cuando forma parte de un plan de seguridad general e integral capaz de tomar en cuenta todos los elementos del contexto ambiental.
Criminología, prevención de la violencia y la agenda 2030 del desarrollo sostenible
Authors: Esquivel Hernández Ana María
Published: September 2021

La Criminología es una ciencia multidisciplinaria, que nos permite tener un universo de actuación en la sociedad, al ser un actor principal en la reducción de la violencia. Por lo cual, en el presente documento, abordaremos una breve revisión del contexto epistemológico de la Criminología, la estadística criminal en el estado de Nuevo León, para abordar la diferencia de la prevención de la violencia, del delito y/o delincuencia, su abordaje desde el marco legal así como sus principales enfoques teóricos, lo que nos lleva a conocer y analizar la Agenda 2030 del Desarrollo Sostenible y las acciones que en este rubro realiza el gobierno mexicano, desde sus instrumentos diseñados para ello para finalmente reflexionar el papel que tiene la Criminología con sus conocimientos aportar a la construcción de las políticas públicas.