bluuebunny/crossref_metadata_2025 huggingface dataset:
Cerebral Oxygenation and Activity During Surgical Repair of Neonates With Congenital Diaphragmatic Hernia: A Center Comparison Analysis
Authors: Costerus Sophie A. , Hendrikx Dries , IJsselmuiden Joen , Zahn Katrin , Perez-Ortiz Alba , Van Huffel Sabine , Flint Robert B. , Caicedo Alexander , Wijnen René , Wessel Lucas , de Graaff Jurgen C. , Tibboel Dick , Naulaers Gunnar
Published: December 2021

Background and aim: Neonatal brain monitoring is increasingly used due to reports of brain injury perioperatively. Little is known about the effect of sedatives (midazolam) and anesthetics (sevoflurane) on cerebral oxygenation (rScO2) and cerebral activity. This study aims to determine these effects in the perioperative period.

Methods: This is an observational, prospective study in two tertiary pediatric surgical centers. All neonates with a congenital diaphragmatic hernia received perioperative cerebral oxygenation and activity measurements. Patients were stratified based on intraoperatively administrated medication: the sevoflurane group (continuous sevoflurane, bolus fentanyl, bolus rocuronium) and the midazolam group (continuous midazolam, continuous fentanyl, and continuous vecuronium).

Results: Intraoperatively, rScO2 was higher in the sevoflurane compared to the midazolam group (84%, IQR 77–95 vs. 65%, IQR 59–76, p = < 0.001), fractional tissue oxygen extraction was lower (14%, IQR 5–21 vs. 31%, IQR 29–40, p = < 0.001), the duration of hypoxia was shorter (2%, IQR 0.4–9.6 vs. 38.6%, IQR 4.9–70, p = 0.023), and cerebral activity decreased more: slow delta: 2.16 vs. 4.35 μV2 (p = 0.0049), fast delta: 0.73 vs. 1.37 μV2 (p = < 0.001). In the first 30 min of the surgical procedure, a 3-fold increase in fast delta (10.48–31.22 μV2) and a 5-fold increase in gamma (1.42–7.58 μV2) were observed in the midazolam group.

Conclusion: Sevoflurane-based anesthesia resulted in increased cerebral oxygenation and decreased cerebral activity, suggesting adequate anesthesia. Midazolam-based anesthesia in neonates with a more severe CDH led to alarmingly low rScO2 values, below hypoxia threshold, and increased values of EEG power during the first 30 min of surgery. This might indicate conscious experience of pain. Integrating population-pharmacokinetic models and multimodal neuromonitoring are needed for personalized pharmacotherapy in these vulnerable patients.

Trial Registration:https://www.trialregister.nl/trial/6972, identifier: NL6972.
Nematode RALF-Like 1 Targets Soybean Malectin-Like Receptor Kinase to Facilitate Parasitism
Authors: Zhang Xin , Wang Dongmei , Chen Jia , Wu Dousheng , Feng Xianzhong , Yu Feng
Published: December 2021

Soybean [Glycine max (L.) Merr. ] is one of the most strategical oilseed crops that provides sustainable source of protein and oil worldwide. Cultivation of soybean is severely affected by root-knot nematode (RKN). However, the mechanism of RKN parasitism to soybeans is largely unknown. In this study, we identify GmLMM1, which encodes a homolog of FERONIA-like receptor kinase in soybean, as a susceptible gene toward nematode. Mutations of GmLMM1 exhibit enhanced resistance against the RKN Meloidogyne incognita. RNA-sequencing (RNA-seq) analysis reveals a similar differential expression pattern for genes regulated by GmLMM1 (Gmlmm1 vs. wild-type) and M. incognita (M. incognita vs. mock), supporting the role of GmLMM1 in M. incognita infection. Unlike FERONIA in Arabidopsis, GmLMM1 specifically binds to MiRALF1 and AtRALF23 that suppress plant immunity, but not MiRALF3 and AtRALF1. Moreover, we found that the single-nucleotide polymorphism (SNP) in GmLMM1 leads to the natural resistance against RKNs in soybeans. Collectively, these findings uncover GmLMM1 as a susceptible target of nematode RALF-like 1 and provide new genetic resource for nematode resistant breeding.
Development and Evaluation of Stable Sugarcane Mosaic Virus Mild Mutants for Cross-Protection Against Infection by Severe Strain
Authors: Xu Xiao-Jie , Zhu Qing , Jiang Shao-Yan , Yan Zhi-Yong , Geng Chao , Tian Yan-Ping , Li Xiang-Dong
Published: December 2021

Sugarcane mosaic virus (SCMV; genus Potyvirus) induces maize dwarf mosaic disease that has caused serious yield losses of maize in China. Cross-protection is one of the efficient strategies to fight against severe virus strains. Although many mild strains have been identified, the spontaneous mutation is one of the challenging problems affecting their application in cross-protection. In this study, we found that the substitution of cysteine (C) at positions 57 or 60 in the zinc finger-like motif of HC-Pro with alanine (A; C57A or C60A) significantly reduced its RNA silencing suppression activity and SCMV virulence. To reduce the risk of mild strains mutating to virulent ones by reverse or complementary mutations, we obtained attenuated SCMV mutants with double-mutations in the zinc finger-like and FRNK motifs of HC-Pro and evaluated their potential application in cross-protection. The results showed that the maize plants infected with FKNK/C60A double-mutant showed symptomless until 95 days post-inoculation and FKNK/C60A cross-protected plants displayed high resistance to severe SCMV strain. This study provides theoretical and material bases for the control of SCMV through cross-protection.
Characteristics of Ethical Leadership: Themes Identification Through Convergent Parallel Mixed Method Design From the Pakistan Context
Authors: Shahab Hina , Zahur Hafsah , Akhtar Naveed , Rashid Sobia
Published: December 2021

The current approaches in identifying the characteristics of ethical leadership proceed mainly from a Western perspective based on virtue-driven moral philosophy (i.e., relativism) and frequently ignoring the Asian perspective of morality based on idealism. This study aimed to conduct parallel analysis in convergent design by using qualitative and quantitative methods to extract person-driven ethical leadership themes by considering the Asian context. Using the hypothetico-deductive method, 13 themes were extracted altogether, out of which 4 are new context-driven themes (i.e., altruism, encouragement, collective good, and spiritual transcendence as the emerging themes of ethical leadership in the Asian context).
An International Comparative Study of Students' Scientific Explanation Based on Cognitive Diagnostic Assessment
Authors: Hu Tao , Yang Jing , Wu Rongxiu , Wu Xiaopeng
Published: December 2021

Scientific explanation is one of the most core concepts in science education, and its mastery level is crucial for a deep understanding of the nature of science. As a new generation of assessment theory, cognitive diagnostic assessment (CDA) can get the knowledge of students' mastery of fine-grained knowledge. Based on the extant research, this research has formed eight attributes of scientific explanation concepts. By coding the Trends in International Mathematics and Science Study (TIMSS) test items, a CAD tool was formed. Data collected from 574 Grade 4 students in Hangzhou, China, combined with the data of the United States, Singapore, Australia, the United Kingdom, and Russia, were used in our study. The Deterministic Inputs, Noisy “And” gate (DINA) model was used to analyze the results from three aspects: the probability of mastery of attributes, the international comparison of knowledge states, and the analysis of learning paths. This study provided a new perspective from a CDA approach on the assessment of scientific explanation.
An Explainable Intelligence Driven Query Prioritization Using Balanced Decision Tree Approach for Multi-Level Psychological Disorders Assessment
Authors: Mishra Sushruta , Tripathy Hrudaya Kumar , Kumar Thakkar Hiren , Garg Deepak , Kotecha Ketan , Pandya Sharnil
Published: December 2021

Human emotions affect psychological health to a great level. Positive emotions relate to health improvement; whereas negative emotions may aggravate psychological disorders such as anxiety, stress, and depression. Although there exist several computational methods to predict psychological disorders, most of them provide a black-box view of uncertainty. This research involves developing a novel predictive model for multi class psychological risk recognition with an accurate explainable interface. Standard questionnaires are utilized as data set and a new approach called a Q-Prioritization is employed to drop insignificant questions from the data set. Moreover, a novel balanced decision tree method based on repetitive oversampling is applied for the training and testing of the model. Predictive nature along with its contributing factors are interpreted with three techniques such as permuted feature importance, contrastive explanation, and counterfactual method, which together form a reasoning engine. The prediction outcome generated an impressive performance with an aggregated accuracy of 98.25%. The mean precision, recall, and F-score metric recorded were 0.98, 0.977, and 0.979, respectively. Also, it was noted that without applying Q-Prioritization, the accuracy significantly drops to 90.25%. The error rate observed with our model was only 0.026. The proposed multi-level psychological disorder predictive model can successfully serve as an assistive deployment for medical experts in the effective treatment of mental health.
A Methodological Approach for Prioritization and Rationalization of Field Genebank Accessions of Coffee Genetic Resources: A Case Study of CATIE International Coffee Collection, Costa Rica
Authors: Dulloo Mohammad Ehsan , Solano William , Dessauw Dominique , Astorga Carlos , Guarino Luigi
Published: December 2021

Good management of coffee collections is important because they ensure long-term availability of germplasm to guarantee the sustainability of coffee value chain. The conservation of coffee genetic resources is essential to provide the raw materials for breeding and improvement of the crop. Many genetic resources of wild arabica coffee have been collected in the second half of the 20th century by several international collecting missions, including by Food and Agriculture Organization of the United Nations, ORSTOM (now IRD), Centre de coopération internationale en recherche agronomique pour le développement (CIRAD), and IPGRI (now Bioversity International), and are conserved in several national genebanks and at the CATIE International Coffee Collection (CICC) in Turrialba, Costa Rica. Over the past decades, many of the original accessions of the CICC have become threatened due to age, pests and diseases, inadequate management, and waterlogging. There is thus an urgent need to rejuvenate and rationalize the collection to ensure the long-term maintenance of the genetic diversity of the original accessions. Here we present the methodological approach we followed to carry out an in-depth assessment of the status of the coffee collection at CATIE and to prioritize accession-specific actions for the rationalization of the collection. This can be used as a model for other collections to assess and rationalize their own field genebank, with a view to improving their management in the most cost-effective way. The study identified many discrepancies between the number of accessions in the field and genebank records and revealed that 80 accessions have been lost from the collection since 2014 and that approximately 80% of the accessions were threatened and in need of intervention. Furthermore, the in-depth study identified the most diverse and valued accessions for the rationalization of the CICC field genebank and those that are in urgent need of safety duplication.
Extensive Abdominal Skin Necrosis Following Anterior Component Separation for a Large Ventral Hernia: A Case Report
Authors: Bakula Branko , Sever Marko , Karačić Andrija , Bakula Mirko , Grbavac Martin , Romic Ivan , Bogut Ante , Zadro Zvonko
Published: December 2021

Introduction: Hernia surgery is one of the most common operative procedures, performed in about 20 million cases per year all over the world, with ventral hernia accounting for about 30% of the cases. Although the introduction of the anterior component separation (ACS) method, popularized primarily by Oscar Ramirez, has greatly facilitated the closure of the largest abdominal wall defects, the 30-year experience in this technique has pointed to the risk of ischemic skin complications consequential to the major subcutaneous tissue dissection required. The aim of this case presentation of a patient who developed extensive necrosis of the abdominal wall skin following ACS procedure is to emphasize the importance of preserving rectus abdominis perforator blood vessels in order to preserve skin vitality.

Case Presentation: We present a case of a 58-year-old female patient with a large recurrent ventral hernia. The hernial defect was closed by placing a large (30 × 25 cm) polypropylene mesh in the retro-rectus space using the Rives-Stoppa technique. To facilitate upper fascia closure ACS according to Ramirez was performed bilaterally. The rectus perforator vessels were not preserved. Recovery of the patient was complicated with the extensive abdominal skin necrosis which was successfully treated with negative pressure wound therapy.

Discussion: Transection of the musculocutaneous perforators of the epigastric artery during ACS results with the compromised blood supply of the abdominal skin depending solely upon the intercostal arteries. Skin ischemia following ACS is a serious complication that can be presented with extensive necrosis associated with high morbidity and even mortality, while the treatment is long lasting, complex, and expensive. Considering the ever-increasing prevalence of large ventral hernias, ever greater popularity of the ACS technique, and the growing proportion of surgeons performing large ventral hernia operations independently, we think that the role of preserving perforated rectus vessels has not been emphasized enough. Therefore, the objective of this case study is to stimulate surgeons to preserve skin vascularity and promote it in their routine in order to avoid these severe postoperative complications.
Effects of Bedding Material on Equine Lower Airway Inflammation: A Comparison of Two Peat Beddings, Wood Pellet, and Straw Pellet
Authors: Mönki Jenni , Saastamoinen Markku , Karikoski Ninja , Norring Marianna , Rajamäki Minna , Mykkänen Anna
Published: December 2021

The effects of bedding material on air quality are important amongst horses worldwide. Respiratory diseases, especially equine asthma, are highly prevalent with air hygiene playing a major role on the pathophysiology of these diseases. The objective of our study was to investigate the effects of four bedding materials on the respiratory signs, tracheal mucus score, and tracheal wash (TW) and bronchoalveolar lavage fluid (BALF) cytology in healthy adult horses. The study design was a prospective controlled cross-over study, and the subjects were healthy adult riding school horses (n = 32) from a single stable. Wood pellet, straw pellet, and loosely stored peat (Peat 3) were compared to peat packed in plastic-covered bales (Peat 2). Lower airway endoscopy and sampling (TW and BALF) for cytological examination were performed after each 35-day bedding period. The tracheal mucus scores (P = 0.014) and respiratory rate (P = 0.026) were higher during the straw pellet period compared to the Peat 2 period. The respiratory rate was lower during the wood pellet period compared to the Peat 2 period (P = 0.004). The TW neutrophil percentage during the straw pellet period was higher compared to the Peat 2 period (P = 0.0003). The BALF neutrophil percentage was higher during the straw pellet period (P = 0.005) and during the Peat 3 period compared to the Peat 2 period (P = 0.04). We conclude that baled peat (Peat 2) caused lower neutrophil percentages in the airway samples compared to straw pellet and loosely stored peat (Peat 3). No difference was observed between Peat 2 and wood pellet. The information gained from this study may assist veterinarians and horse owners in selecting appropriate bedding materials, especially for horses with equine asthma.
Serum Tie-1 is a Valuable Marker for Predicting the Progression and Prognosis of Cervical Cancer
Authors: Bai Rui , Diao Bowen , Li Kaili , Xu Xiaohan , Yang Ping
Published: December 2021

Objective: To investigate whether serum Tie-1 (sTie-1) is a valuable marker for predicting progression and prognosis of cervical cancer.

Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect serum sTie-1 concentrations in 75 cervical cancer patients, 40 cervical intraepithelial neoplasia (CIN) patients, and 55 healthy controls without cervical lesions, and sTie-1 levels were compared between the groups. Receiver operating characteristic curves was used to evaluate the diagnostic value of sTie-1. The relationship between sTie-1 concentrations in patients with cervical cancer and clinicopathological features and prognosis were analyzed, and the risk factors for postoperative recurrence were determined using univariate and multivariable Cox proportional hazards regression.

Results: We found that sTie-1 concentrations gradually increased according to lesion severity (i.e., cancer vs. CIN; p < 0.05) and were significantly elevated in adenocarcinoma compared with healthy controls. sTie-1 levels strongly distinguished between cervical cancer patients and the healthy controls (area under the curve = 0.846; cut-off value = 1,882.64 pg/ml; sensitivity = 74.6%; specificity = 96.4%). Moreover, sTie-1 levels in cervical cancer patients were significantly associated with tumor size, advanced tumor stage, lymph node metastasis, and reduced 4-years progression-free survival. Cervical cancer patients with high sTie-1 concentrations had a 3.123-fold [95% confidence interval (CI): 1.087–8.971, p = 0.034] higher risk for tumor recurrence.

Conclusions: Elevated sTie-1 levels in patients with cervical carcinoma were associated with tumor progression and poor prognosis, indicating that sTie-1 may be a valuable marker for predicting progression and prognosis of cervical cancer.
A Roadmap for the Sustainable Valorization of Accessible Underwater Cultural Heritage Sites
Authors: Manglis Angelos , Fourkiotou Anastasia , Papadopoulou Dimitra
Published: December 2021

This paper presents a roadmap to enable the adoption of the BLUEMED model; an integrated plan developed within the BLUEMED project that promotes underwater cultural heritage (UCH) to both divers and non-divers and aims at sustainable tourism development in coastal areas and islands. Through augmented and virtual reality technologies, one can experience wet and dry diving to accessible underwater cultural heritage site(s) (AUCHS), through a physical dive at the sites or a virtual tour at Knowledge Awareness Centers (KACs). The roadmap provides guidelines, so that relevant stakeholders and competent authorities can implement the BLUEMED model and consider the various environmental, cultural, and socioeconomic factors of the area (locality), to ensure viability in the long-term. The roadmap focuses on the policy and technical parameters, including the cultural and environmental features of the site, the legislative framework, funding issues, the integration of technologies, the prospects for sustainable tourism development in the area, the stakeholder engagement, and the cooperation framework within a top-down or a bottom-up initiative, as well as the establishment and operation of the KACs.
Waste to Wealth Strategy: Preparation and Properties of Lightweight Al2O3-SiO2-Rich Castables Using Aluminum Dross Waste
Authors: Su Nan , Li Zishen , Ding Youdong , Yang Hongliang , Zhang Jingzhou , Fu Gaofeng
Published: December 2021

Aluminum dross is a well-known industrial waste generated in the aluminium industry, and its recycling and reuse is still a worldwide issue. Herein, aluminum dross waste (ADW) was recycled to progressively replace the aggregate fraction of clay at 70, 75, 80, 85, and 90 wt% for the fabrication of Al2O3-SiO2-rich porous castable refractories. Their physical properties and mechanical behavior were assessed by the measurement of linear shrinkage rate, bulk density, apparent porosity, cold crushing strength, and thermal conductivity. The microstructure and phase evolutions were analyzed via scanning electron microscopy (SEM) and X-ray diffraction (XRD). The incorporation of 85 wt% of ADW allowed the development of a waste-containing conventional refractory castable with improved properties as compared to those of the other samples. The sustainable refractory castable exhibited decent thermal conductivity and physical and mechanical characteristics, and is suitable for application as reheating furnace lining. It is a “green” practice to partially replace the traditional raw materials with industrial waste in the manufacture of conventional refractory castables and provides environmental and economic benefits.
A g-Type Lysozyme from Deep-Sea Hydrothermal Vent Shrimp Kills Selectively Gram-Negative Bacteria
Authors: Luo Jing-Chang , Zhang Jian , Sun Li
Published: December 2021

Lysozyme is a key effector molecule of the innate immune system in both vertebrate and invertebrate. It is classified into six types, one of which is the goose-type (g-type). To date, no study on g-type lysozyme in crustacean has been documented. Here, we report the identification and characterization of a g-type lysozyme (named LysG1) from the shrimp inhabiting a deep-sea hydrothermal vent in Manus Basin. LysG1 possesses conserved structural features of g-type lysozymes. The recombinant LysG1 (rLysG1) exhibited no muramidase activity and killed selectively Gram-negative bacteria in a manner that depended on temperature, pH, and metal ions. rLysG1 bound target bacteria via interaction with bacterial cell wall components, notably lipopolysaccharide (LPS), and induced cellular membrane permeabilization, which eventually caused cell lysis. The endotoxin-binding capacity enabled rLysG1 to alleviate the inflammatory response induced by LPS. Mutation analysis showed that the bacterial binding and killing activities of rLysG1 required the integrity of the conserved α3 and 4 helixes of the protein. Together, these results provide the first insight into the activity and working mechanism of g-type lysozyme in crustacean and deep-sea organisms.
Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway
Authors: Alaaeldin Rania , Abdel-Rahman Iman A. M. , Hassan Heba Ali , Youssef Nancy , Allam Ahmed E. , Abdelwahab Sayed F. , Zhao Qing-Li , Fathy Moustafa
Published: December 2021

Insulin resistance contributes to several disorders including type 2 diabetes and cardiovascular diseases. Carpachromene is a natural active compound that inhibits α-glucosidase enzyme. The aim of the present study is to investigate the potential activity of carpachromene on glucose consumption, metabolism and insulin signalling in a HepG2 cells insulin resistant model. A HepG2 insulin resistant cell model (HepG2/IRM) was established. Cell viability assay of HepG2/IRM cells was performed after carpachromene/metformin treatment. Glucose concentration and glycogen content were determined. Western blot analysis of insulin receptor, IRS1, IRS2, PI3k, Akt, GSK3, FoxO1 proteins after carpachromene treatment was performed. Phosphoenolpyruvate carboxykinase (PEPCK) and hexokinase (HK) enzymes activity was also estimated. Viability of HepG2/IRM cells was over 90% after carpachromene treatment at concentrations 6.3, 10, and 20 µg/mL. Treatment of HepG2/IRM cells with carpachromene decreased glucose concentration in a concentration- and time-dependant manner. In addition, carpachromene increased glycogen content of HepG2/IRM cells. Moreover, carpachromene treatment of HepG2/IRM cells significantly increased the expression of phosphorylated/total ratios of IR, IRS1, PI3K, Akt, GSK3, and FoxO1 proteins. Furthermore, PEPCK enzyme activity was significantly decreased, and HK enzyme activity was significantly increased after carpachromene treatment. The present study examined, for the first time, the potential antidiabetic activity of carpachromene on a biochemical and molecular basis. It increased the expression ratio of insulin receptor and IRS1 which further phosphorylated/activated PI3K/Akt pathway and phosphorylated/inhibited GSK3 and FoxO1 proteins. Our findings revealed that carpachromene showed central molecular regulation of glucose metabolism and insulin signalling via IR/IRS1/ PI3K/Akt/GSK3/FoxO1 pathway.
Theoretical Prediction and Explanation of Reaction Site Selectivity in the Addition of a Phenoxy Group to Perfluoropyrimidine, Perfluoropyridazine, and Perfluoropyrazine
Authors: Fuhrer Timothy J. , Houck Matthew , Chapman Rachel M. , Iacono Scott T.
Published: December 2021

Perfluoroaromatics, such as perfluoropyridine and perfluorobenzene, are privileged synthetic scaffolds in organofluorine methodology, undergoing a series of regioselective substitution reactions with a variety of nucleophiles. This unique chemical behavior allows for the synthesis of many perfluoroaromatic derived molecules with unique and diverse architectures. Recently, it has been demonstrated that perfluoropyridine and perfluorobenzene can be utilized as precursors for a variety of materials, ranging from high performance polyaryl ethers to promising drug scaffolds. In this work, using density functional theory, we investigate the possibility of perfluoropyrimidine, perfluoropyridazine, and perfluoropyrazine participating in similar substitution reactions. We have found that the first nucleophilic addition of a phenoxide group substitution on perfluoropyrimidine and on perfluoropyridazine would happen at a site para to one of the nitrogen atoms. While previous literature points to mesomeric effects as the primary cause of this phenomenon, our work demonstrates that this effect is enhanced by the fact that the transition states for these reactions result in bond angles that allow the phenoxide to π-complex with the electron-deficient diazine ring. The second substitution on perfluoropyrimidine and on perfluoropyridazine is most likely to happen at the site para to the other nitrogen. The second substitution on perfluoropyrazine is most likely to happen at the site para to the first substitution. The activation energies for these reactions are in line with those reported for perfluoropyridine and suggest that these platforms may also be worth investigation in the lab as possible monomers for high performance polymers.
Kuwanon T and Sanggenon a Isolated from Morus alba Exert Anti-Inflammatory Effects by Regulating NF-κB and HO-1/Nrf2 Signaling Pathways in BV2 and RAW264.7 Cells
Authors: Ko Wonmin , Liu Zhiming , Kim Kwan-Woo , Dong Linsha , Lee Hwan , Kim Na Young , Lee Dong-Sung , Woo Eun-Rhan
Published: December 2021

We previously investigated the methanolic extract of Morus alba bark and characterized 11 compounds from the extract: kuwanon G (1), kuwanon E (2), kuwanon T (3), sanggenon A (4), sanggenon M (5), sanggenol A (6), mulberofuran B (7), mulberofuran G (8), moracin M (9), moracin O (10), and norartocarpanone (11). Herein, we investigated the anti-inflammatory effects of these compounds on microglial cells (BV2) and macrophages (RAW264.7). Among them, 3 and 4 markedly inhibited the lipopolysaccharide (LPS)-induced production of nitric oxide in these cells, suggesting the anti-inflammatory properties of these two compounds. These compounds inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-α, and the expression of inducible nitric oxide synthase and cyclooxygenase-2 following LPS stimulation. Pretreatment with 3 and 4 inhibited the activation of the nuclear factor kappa B signaling pathway in both cell types. The compounds also induced the expression of heme oxygenase (HO)-1 through the activation of nuclear factor erythroid 2-related factor 2. Suppressing the activity of HO-1 reversed the anti-inflammatory effects caused by pretreatment with 3 and 4, suggesting that the anti-inflammatory effects were regulated by HO-1. Taken together, 3 and 4 are potential candidates for developing therapeutic and preventive agents for inflammatory diseases.
Technological Breakthrough for the Afforestation of Populus euphratica in the Mu Us Desert in China
Authors: Tuo Fei , Gao Beibei , Dong Zhibao
Published: December 2021

The Mu Us Desert (MUD) is one of the four largest sandy lands in China. On 22 April 2020, the Shaanxi Forestry Bureau announced that the desertification land control rate in Yulin reached 93.24%, which means that the Mu Us Desert was about to “disappear” from the territory of Shaanxi. However, the problem of biological diversity, mostly for Pinus sylvestris and shrubs in the Mu Us Desert, remains serious. In order to consolidate the current forest conservation efforts, Populus euphratica has been considered an ideal candidate since the 1950s. However, the low survival rate and conservation rate of Populus euphratica in the MUD led us to perform further large-scale introduction for over 70 years. In this study, by using root control seedling technology, the survival and the conservation rate of Populus euphratica were increased to more than 90%. This study makes possible the introduction of Populus euphratica in the MUD, and the successful introduction of Populus euphratica will provide a new barrier for forest ecosystem stability in the desertification control project in the Yulin area.
Divine Thoughts in the View of Abdul Rahuman
Authors: K Yuvarani , R Siva Kumar
Published: December 2021

The thought of the Lord appears when one looks at the events seen in daily life and thinks deeply about them. Therefore, “Irai Sinthanai Thoughts in the View of Abdul Rahuman' is chosen as the title of this review article to convey the ideas, thoughts, beliefs, etc. about God. The study is carried out in such terms as algorithms. In the sense that these creations are deified, all living and inanimate objects in the world were created by the one and only God, and that religions call these things by the names of heredity, paramanma, god, lord, and that religions and religious principles should be in place to dispel the prejudice of men who claim that their religious god is the best. Since God holds within Himself all the powers of the giants, such as land, water, air, fire, and sky, which are necessary for life to exist, it makes sense that discriminating against God in His creation is tantamount to distinguishing Himself. In the sense of divine experience, we must reach the Lord who bestows that pleasure so that the lives in the world may attain lasting happiness and pleasure. That is the bliss of eternal bliss, and when that life reaches that state of bliss the two become one with the Lord. There are many saints and saints who have attained such supremacy. They have realized and realized the divine vision and divine experience that they have seen through her experience. Thus, Abdul Rahuman is situated in the pleasure of music, in the rhythm of beauty, in the experience of bliss, in the expression of joy, in a way that is indescribable in words, and in the way he realizes his divine experience as one who has seen and experienced God. In the sense of the means of attaining the Lord, just as the pious theologians show how to receive the grace of the Lord, Abdul Rahman also exemplifies the pursuit of worldly pleasures and attachments, helping one another, living in harmony with virtues without succumbing to vices, such as arrogance. Abdul Rahman points out that the only way to attain God is through the attainment of maturity by realizing through his experience that God is responsible for all the deeds in this world.
APLIKASI ALGORITMA FLOYD-WARSHALL DENGAN PENDEKATAN MADM DALAM MENENTUKAN RUTE TERPENDEK PENGANGKUTAN SAMPAH
Authors: Buako Zulmagfir , Yahya Lailany , Achmad Novianita
Published: December 2021

Currently, the problem of environmental hygiene caused by the accumulation of garbage becomes a serious problem for every community. In addressing this problem, an efficient waste transport process is required. This study aims to find the shortest route of garbage transportation in Gorontalo city by using Floyd Warshall Algorithm by finding the smallest weight between each point (Vertex). In this study, the weights used in the Floyd Warshall Iteration Algorithm were Alternative weights obtained by the Multi-Attribute Decision-Making approach (MADM). The criteria for determining weights in MADM use three indicators that affect the efficiency of garbage transportation, namely Distance, time, and congestion. The route used in this study is the dump truck route with 17 garbage transportation points. After obtaining the Alternate weight and iteration using Floyd Warshall algorithm obtained the shortest route with the smallest trajectory weight of 110.845.
PENGARUH MODEL PENEMUAN TERBIMBING TERHADAP HASIL BELAJAR PADA MATERI PRISMA DAN LIMAS DI SMP NEGERI I TALAGA JAYA
Authors: Mahmud Sri Lestari , Mohidin Abdul Djabar , Bito Nursiya , Zakiyah Siti
Published: December 2021

This research aims to look at the influence of guided discovery learning models on students' learning outcomes. The type of research used is experimental research. Sampling in this research was conducted by simple random sampling technique. Data collection was carried out using instruments in the form of observation sheets and tests of learning outcomes. The data obtained is then analyzed descriptively and inferentially. The results of the data analysis showed that the students’ learning outcomes taught by the guided discovery model are higher than students’ learning outcomes taught by conventional models, and the guided discovery model was effective in teaching material surface area and volume of upright and pyramid prisms.
KEMAMPUAN SISWA DALAM MENGAITKAN OBJEK MATEMATIKA PADA SOAL POLA BILANGAN
Authors: Tatu Amalia , Ismail Sumarno , Resmawan Resmawan , Djakaria Ismail , Usman Kartin , Isa Dewi Rahmawati
Published: December 2021

This research was conducted with the aim of knowing to what extent students' ability to relate mathematical objects to problems number patterns. The method used in this research is a quantitative description. The data collection techniques used are tests and interviews. The data analysis technique uses model miles and hiberman, namely by reducing data, presenting data, and drawing conclusions. The results showed that students' ability to relate mathematical objects to pattern problems numbers is not maximized. This is indicated by the percentage of achievements an indicator of the ability to associate mathematical objects that only reached an average of 55.26% consisting of 48.44% fact indicators, concept 45.50%, principle 63.80%, and operation 63.33%.
THE CONCEPT OF IOT SYSTEMS FOR AGRICULTURAL SERVICES WITH A HIGH DEGREE OF AUTONOMY
Authors: Хаджиева Л. К. , Хаджиев М. Р. , Исрахимова А. Т.
Published: December 2021

В статье рассматриваются вопросы, связанные с использованием новейшей технологии IOT в сельском хозяйстве, показана основная роль Интернета вещей в сельском хозяйстве, которая заключается в том, чтобы можно было контролировать всю важную информацию благодаря оснащённому последними передовыми технологиями оборудованию. А также проанализированы возможности внедрения технологии IOT в агропромышленности, благодаря которой можно с легкостью отслеживать необходимые данные, такие как влажность, качество почвы, температура воздуха, также показаны возможности, которые появляются благодаря использованию дистанционных датчиков. Цель использования технологии, ее необходимость для повышения урожайности и планирования более результативной системы полива и составления прогнозов. Описана необходимость, технологии Интернета вещей в исследовании биологов, для воздействия геномов и микроклимата на степень урожайности, для возможного увеличения качества и производительности продукции. Идет описание вопросов касательно экологических проблем.

The article examines the issues related to the use of the latest IOT technology in agriculture, shows the main role of the Internet of Things in agriculture, which is to control all important information thanks to the equipment equipped with the latest advanced technologies. It also analyzed the possibilities of introducing IOT technology in the agricultural industry, thanks to which it is possible to easily track the necessary data, such as moisture, soil quality, air temperature, and also shows the possibilities that arise due to the use of remote sensors. The purpose of using the technology is its need for increasing yields and planning a more efficient irrigation system and making forecasts. The necessity of the Internet of Things technology in the study of biologists, for the influence of genomes and microclimate on the degree of productivity, for a possible increase in the quality and productivity of products is described. There is a description of questions regarding environmental issues.
PROJEKTOWANIE UNIWERSALNE PRZESTRZENI W PRZEDSZKOLU JAKO ODPOWIEDŹ NA SZCZEGÓLNE POTRZEBY DZIECI
Authors: Wieruszewska-Duraj Sabina
Published: December 2021

Universal design of space in a kindergarten should be aimed at creating full accessibility of public space that will meet the expectations of all children, regardless of age, health condition or limitations of mobility or perception. The universal availability of space determines the proper development of an individual. In order to improve the safety and limit the social exclusion of children, including children with special educational needs, one should strive to shape an environment based on the principles of universal design. The article presents the assumptions for the design and arrangement of a child's space in a kindergarten taking into account its needs, and discusses issues related to the elimination of spatial barriers that increase safety and independence in the child's personal development.
MODEL MOCNYCH STRON A DZIAŁANIA POMOCOWE W UCZELNI
Authors: Zacharuk Tamara , Sobczak Sławomir
Published: December 2021

The study focuses on the characteristics of strengths-based model in the form of psychological and social resources of the disabled student. The analysis takes into consideration the effects of interpersonal relations in the academic context, as well as the outcomes of the disabled student support system implemented at Siedlce University. The study is based on the assumption that assistance and support elements of the programme are pivotal for the disabled student’s sense of support of the disabled student. According to the premises of positive psychology, the characteristics that constitute the strengths of an individual were singled out. The respondents, who were Siedlce University students, were asked to assess the increase of their competences, the senseof development of potential, as well as the feeling of fulfilment and control over their own lives. The sum of these elements was treated as the total assessment of the psychological and social resources that students have at their disposal. To determine statistically significant differences between the assessment of particular features of the model in the perception of the disabled and able-bodied student, a linear regression analysis and a one-factor analysis of variance were carried out. It was found that students with disabilities obtained higher means with regard to the sense of increase in competence and the feeling of support than those without disabilities, where these differences were statistically significant. The able-bodied respondents significantly assessed the feeling of control over their own lives more than the disabled students. As far as the sense of development of their own potential and the feeling of fulfilment are concerned, the means for both respondent groups did not differ statistically significantly. The evaluation of the inclusion model, i.e. psychological and social resources, was identified to be at the same level in both groups. On the basis of the linear regression analysis, it could be stated that all features of the strengths-based model correlate strongly positively with the feeling of received support. The results of the present study point to the conclusion that the inclusive model integrating disabled students with their able peers, academic teachers, and administration personnel, which has been applied at Siedlce University (Poland) for over 50 years, brings certain positive effects not only for the disabled student but also for the one without any deficits.
mandatos de masculinidad en la cotidianeidad de la prisión
Authors: Marengo Malvina
Published: December 2021

En este escrito, se toman aportes de los estudios  de  género  y  del  psicoanálisis para analizar los  efectos  que  tiene  la  institución  penitenciaria  como  productora y reproductora de mandatos patriarcales,  a  partir  del  relato  teórico  y  vivencial de algunos aspectos de la cotidianeidad de la vida en la prisión. Para ello, será fundamental contemplar cómo se construyen las masculinidades de quiénes habitan esos espacios (detenidos y agentes penitenciarios) y qué roles desempeñan los otros hombres y las mujeres, entendiendo que tanto la violencia como el ejercicio de poder se constituyen en elementos ineludibles para un análisis institucional. Finalmente, se abre el siguiente interrogante: si no se cuestionan las estructuras patriarcales, ¿es este un lugar eficaz para enfrentar y tratar la violencia machista?
Amor, trabajo y (des) protección social.
Authors: Cutuli Romina , Camou Rosario , Colombo Antonella , Vinitzky Marianella
Published: December 2021

En este artículo se analizan las condiciones de familiarización y feminización del cuidado de personas mayores en la ciudad de Mar del Plata, Argentina. En el país, la organización social del cuidado y las normativas que la regulan están signadas por un marcado familiarismo, lo que restringe las oportunidades de autonomía de las personas cuidadoras y limita el acceso a cuidados de calidad y bienestar material a las personas mayores. El Estado se hace presente en situaciones de extrema gravedad o ausencia de redes familiares, imponiendo la tensión entre el abandono y la resignación del proyecto de vida propio. La investigación que se recupera en este artículo se inició en un contexto anterior a la declaración de la pandemia y continuó, con adaptaciones metodológicas, en los primeros dos meses de pandemia. Recuperamos, a través de entrevistas y un cuestionario autoadministrado, la experiencia de mujeres cuidadoras no remuneradas de personas mayores, su perspectiva sobre el impacto del cuidado no remunerado en sus proyectos de vida y las representaciones subjetivas en torno a la labor que realizan.
Intervenciones del trabajo social desde el poder judicial en situaciones de Violencia familiar.
Authors: Pascual Viviana Elisa , Martino Silvana
Published: December 2021

El presente artículo tiene como propósito recuperar una de las situaciones que requieren la intervención del trabajador social a diario, y cómo de esa cotidianeidad se llega a una naturalización/rutinización de las nociones, posiciones y fundamentos que atraviesan la práctica profesional de manera decisiva. Se propone desandar las acciones y omisiones que se fueron realizando a lo largo de una situación de violencia familiar que llega al poder judicial y requiere imperiosamente ser abordada. Desde allí, intentamos re preguntarnos acerca de nuestro quehacer y el de les agentes implicades en dicho proceso, con la certeza que re pensarnos e interpelarnos no solo nos permite producir conocimientos acerca de nuestras prácticas y experiencias, sino reafirmar nuestra posición ética política en el acceso a la justicia de los vulnerados, en este caso, mujeres y niñes víctimas de violencia familiar.
Identificación de víctimas por parte del Comité Municipal de Lucha Contra la Trata de Personas de Bucaramanga.
Authors: Sandoval Bueno Cristian David
Published: December 2021

El presente artículo expone los resultados de un proyecto de investigación que indagó por los procesos de identificación de víctimas de trata de personas por parte del Comité Municipal de Lucha Contra la Trata de Personas de Bucaramanga, Colombia, con el objetivo principal de conocer los procesos de identificación de las mismas. Para dar cumplimiento a este último, se realizó un estudio de caso múltiple. Entre los hallazgos principales se encontró que la identificación de víctimas se compone de tres momentos: recepción del caso, análisis del caso y activación de ruta de asistencia. Sobre la recepción del caso, esta suele ser de forma pasiva, es decir, a través de denuncias ciudadanas o víctimas remitidas por otras instituciones. Respecto al análisis de casos y activación de ruta de asistencia, están centralizadas en las labores administrativas de la secretaría técnica del comité. En síntesis, los procesos de identificación de víctimas de trata parecen ser más procesos administrativos de construcción de caso en los cuales lo más importante son las labores de papeleo para la identificación de una presunta víctima.
Trabajo profesional de les trabajadores sociales en contexto de pandemia por COVID-19.
Authors: Escurra María Isabel
Published: December 2021

Proponemos aproximarnos a caracterizar aspectos del trabajo profesional de les trabajadores sociales en el marco de la pandemia por COVID-19, específicamente durante el año 2020 y centrándonos en las posibilidades de construcción de autonomía profesional. Concibiendo la pausa reflexiva y colectiva como instancia necesaria para construir mayor autonomía profesional, pues el encuentro y el diálogo permiten compartir estrategias, imprimir direcciones y formas de encaminar colectivamente las intervenciones, resistencias y las luchas por la materialización de derechos. El recorte tempo-espacial señalado responde a los cambios en los procesos de trabajo en contexto de pandemia, sin desconocer cuestiones que van más allá de su irrupción. Por lo tanto intentamos esbozar aspectos centrales en torno a la crisis societal contemporánea, su relación con la pandemia y el trabajo profesional. Para abordar el tema propuesto, retomamos reflexiones de compañeras que se desempeñan en instituciones de salud de una ciudad media de la provincia de Buenos Aires y de Ciudad Autónoma de Buenos Aires en torno a: sus espacios socio profesionales, limitaciones, posibilidades y desafíos presentes. Dichas reflexiones fueron compartidas en el “Ciclo de Diálogos desde la experiencia en contextos de pandemia: Estado, Políticas Sociales y Prácticas profesionales. Realidades y desafíos”, convocado por las cátedras de Trabajo Social 1 y Estado y Política de Social de la Lic. en Trabajo Social, FCH, UNCPBA durante noviembre de 2020.
Replanteos epistemológicos en justicia juvenil
Authors: De Bella Karina
Published: December 2021

El objetivo de este artículo es desnaturalizar la instalación acrítica del discurso punitivo en materia de justicia juvenil. Hablar de justicia juvenil o justicia penal juvenil remite a matrices de pensamiento, articulaciones institucionales y políticas muy diferentes. Es frecuente hallar, sin embargo, en los procesos de formación de distintas disciplinas como el Derecho y específicamente el Trabajo Social, la especial recurrencia a un marco conceptual estereotipado que reduce la cuestión de los derechos de niñes y adolescentes a dos posiciones paradigmáticas: el paradigma de la situación irregular y el paradigma de la protección integral. Hablar de paradigmas remite a la posición epistemológica khuntiana que discutiremos en el marco de este trabajo, en tanto no resulta una concepción sobre el desarrollo del conocimiento que compartamos. En América Latina, esta forma de concebir los cambios en el campo de la justicia ha reducido la problemática de la justicia juvenil en torno a la idea predominante de la necesidad de cambios legales y procesales, subsumiendo las discusiones solo al orden jurídico-normativo. Optar por ampliar estas discusiones implica desafíos para el Trabajo Social forense que son asumidos desde el enfoque restaurativo que adoptamos.